gene_id Sample_name Read_count FPKM Gene Length NR GI NR ID NR Score NR Evalue NR Description NT GI NT ID NT Score NT Evalue NT Description KO ID KO Name KO Description Http Link Swissprot ID Swissprot Score Swissprot Evalue Swissprot Description PFAM ID PFAM description Gene Ontology Biological Pathway BP Description Gene Ontology Molecular Function MF Description Gene Ontology Cellular Component CC Description KOG ID KOG Description Cluster-0.0 BP_3 21.00 1.79 858 755865379 XP_011291125.1 241 6.3e-18 PREDICTED: glycine-rich cell wall structural protein-like [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02513 Spin/Ssty Family GO:0007276 gamete generation -- -- -- -- -- -- Cluster-1.0 BP_3 6.00 1.85 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10.0 BP_3 45.00 4.57 766 171473640 YP_001798472.1 981 8.8e-104 cytochrome c oxidase subunit III (mitochondrion) [Cryptopygus antarcticus]>gi|154100262|gb|ABS57570.1| cytochrome c oxidase subunit III (mitochondrion) [Cryptopygus antarcticus] 169640948 EU527333.1 88 4.04509e-36 Gampsocleis gratiosa mitochondrion, complete genome K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 P00417 905 2.3e-96 Cytochrome c oxidase subunit 3 OS=Drosophila melanogaster GN=mt:CoIII PE=3 SV=1 -- -- GO:0015992//GO:0019646//GO:0006123 proton transport//aerobic electron transport chain//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005739//GO:0016021 respiratory chain complex IV//mitochondrion//integral component of membrane KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-100.1 BP_3 4.00 1.70 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10002.0 BP_3 5.00 0.33 1031 -- -- -- -- -- 42794088 AC135916.2 1025 0 Genomic sequence for Oryza sativa, Nipponbare strain, clone OSJNBa0088M06, from chromosome 5, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10006.0 BP_3 6.72 0.39 1130 290463025 ADD24560.1 165 5.4e-09 Heat shock protein homolog [Lepeophtheirus salmonis]>gi|290561282|gb|ADD38043.1| Heat shock protein homolog [Lepeophtheirus salmonis] -- -- -- -- -- -- -- -- -- P82147 153 5.5e-09 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-10012.0 BP_3 4.00 0.38 799 675377463 KFM70365.1 232 6.5e-17 Chondroitin proteoglycan 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- O76217 148 1.5e-08 Peritrophin-1 OS=Anopheles gambiae GN=Aper1 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-10014.0 BP_3 4.00 0.45 719 -- -- -- -- -- 768311754 CP010982.1 719 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- O59744 148 1.3e-08 Uncharacterized transcriptional regulatory protein C530.08 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC530.08 PE=3 SV=1 PF00172 Fungal Zn(2)-Cys(6) binuclear cluster domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0000981 zinc ion binding//RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-10018.0 BP_3 8.00 0.93 705 78042492 NP_001030186.1 564 1.8e-55 60S ribosomal protein L23 [Bos taurus]>gi|74267764|gb|AAI02557.1| Ribosomal protein L23 [Bos taurus] 697089344 XM_009659287.1 699 0 Verticillium dahliae VdLs.17 60S ribosomal protein L23 mRNA K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P0CX41 579 1.4e-58 60S ribosomal protein L23-A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL23A PE=1 SV=1 PF00238 Ribosomal protein L14p/L23e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0022625//GO:0005840 cytosolic large ribosomal subunit//ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-10023.0 BP_3 15.00 0.33 2453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10039.0 BP_3 7.00 0.44 1066 156539833 XP_001600606.1 148 4.8e-07 PREDICTED: MD-2-related lipid-recognition protein-like, partial [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10041.0 BP_3 16.00 1.14 971 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10043.0 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10050.0 BP_3 2.00 0.57 462 253735765 NP_001156673.1 209 1.7e-14 cuticle protein precursor [Acyrthosiphon pisum]>gi|239791853|dbj|BAH72338.1| ACYPI001681 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-1006.0 BP_3 2.00 0.86 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10061.0 BP_3 14.00 0.52 1601 642915636 XP_008190692.1 890 6.5e-93 PREDICTED: orthodenticle-2 isoform X1 [Tribolium castaneum] 847154230 XM_012968359.1 62 2.45693e-21 PREDICTED: Xenopus (Silurana) tropicalis cone-rod homeobox (crx), transcript variant X1, mRNA K09326 OTX1 homeobox protein OTX1 http://www.genome.jp/dbget-bin/www_bget?ko:K09326 Q90267 373 2.4e-34 Homeobox protein OTX1 A OS=Danio rerio GN=otx1a PE=2 SV=1 PF05920//PF03999//PF00046 Homeobox KN domain//Microtubule associated protein (MAP65/ASE1 family)//Homeobox domain GO:0000226//GO:0000910//GO:0006355 microtubule cytoskeleton organization//cytokinesis//regulation of transcription, DNA-templated GO:0003677//GO:0008017 DNA binding//microtubule binding GO:0045298 tubulin complex KOG2251 Homeobox transcription factor Cluster-10066.0 BP_3 4.00 0.50 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10071.0 BP_3 23.00 0.91 1506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10071.1 BP_3 27.00 1.21 1366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10076.0 BP_3 2.00 0.32 589 -- -- -- -- -- 768311752 CP010980.1 577 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10082.0 BP_3 9.00 0.68 933 91088161 XP_976346.1 483 5.9e-46 PREDICTED: uncharacterized protein LOC660496 [Tribolium castaneum]>gi|270012122|gb|EFA08570.1| hypothetical protein TcasGA2_TC006225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10083.0 BP_3 4.00 0.66 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10099.0 BP_3 1.00 0.39 415 321479079 EFX90035.1 502 1.7e-48 hypothetical protein DAPPUDRAFT_300090 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q8BHN5 291 2.0e-25 RNA-binding protein 45 OS=Mus musculus GN=Rbm45 PE=2 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- -- -- Cluster-101.0 BP_3 8.00 1.89 496 546673130 ERL84795.1 177 9.6e-11 hypothetical protein D910_02220 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10103.1 BP_3 2.00 0.60 451 321465982 EFX76980.1 396 3.5e-36 hypothetical protein DAPPUDRAFT_306029 [Daphnia pulex] -- -- -- -- -- K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P55859 323 4.2e-29 Purine nucleoside phosphorylase OS=Bos taurus GN=PNP PE=1 SV=3 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-10107.0 BP_3 6.00 0.39 1042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q0VCT2 125 8.9e-06 Transmembrane protein 59-like OS=Bos taurus GN=TMEM59L PE=2 SV=1 PF06459//PF11561//PF08496 Ryanodine Receptor TM 4-6//Single strand annealing-weakened 1//Peptidase family S49 N-terminal GO:0006816//GO:0000736//GO:0006874 calcium ion transport//double-strand break repair via single-strand annealing, removal of nonhomologous ends//cellular calcium ion homeostasis GO:0005219//GO:0070336//GO:0004252 ryanodine-sensitive calcium-release channel activity//flap-structured DNA binding//serine-type endopeptidase activity GO:0016021//GO:0005886//GO:0005622 integral component of membrane//plasma membrane//intracellular -- -- Cluster-1011.0 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10117.0 BP_3 7.00 0.38 1170 -- -- -- -- -- 768311757 CP010985.1 1158 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10118.0 BP_3 4.00 0.43 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00956 Nucleosome assembly protein (NAP) GO:0006334 nucleosome assembly -- -- GO:0005634 nucleus -- -- Cluster-1012.0 BP_3 3.00 0.98 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10121.0 BP_3 13.66 0.59 1404 342326191 AEL23011.1 612 9.9e-61 reticulon-1 [Cherax quadricarinatus] -- -- -- -- -- -- -- -- -- Q6IFY7 513 1.2e-50 Reticulon-1-A OS=Xenopus laevis GN=rtn1-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1792 Reticulon Cluster-10123.0 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10127.0 BP_3 2.00 0.36 563 817081421 XP_012263224.1 147 3.3e-07 PREDICTED: cleavage and polyadenylation specificity factor subunit CG7185 isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q9VSH4 127 2.8e-06 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-10127.1 BP_3 9.00 0.38 1432 646718923 KDR21226.1 382 4.7e-34 Cleavage and polyadenylation specificity factor subunit [Zootermopsis nevadensis] -- -- -- -- -- K14398 CPSF6_7 cleavage and polyadenylation specificity factor subunit 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14398 Q9VSH4 336 4.2e-30 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4849 mRNA cleavage factor I subunit/CPSF subunit Cluster-10128.0 BP_3 6.00 0.98 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1013.0 BP_3 7.00 1.08 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10134.0 BP_3 14.00 1.48 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10135.0 BP_3 3.00 0.35 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10136.0 BP_3 3.00 0.53 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10138.0 BP_3 5.00 1.29 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10142.0 BP_3 6.00 0.46 924 13021909 AAK11577.1 1291 1.2e-139 MHC class II antigen precursor [Homo sapiens]>gi|21635632|gb|AAM69677.1| MHC class II antigen [Homo sapiens]>gi|52840196|gb|AAU87992.1| MHC class II antigen [Homo sapiens]>gi|189054169|dbj|BAG36689.1| unnamed protein product [Homo sapiens]>gi|758095313|emb|CEL26596.1| MHC class II antigen [Homo sapiens] 52426772 NM_002122.3 918 0 Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), mRNA K06752 MHC2 major histocompatibility complex, class II http://www.genome.jp/dbget-bin/www_bget?ko:K06752 P01906 1143 7.1e-124 HLA class II histocompatibility antigen, DQ alpha 2 chain OS=Homo sapiens GN=HLA-DQA2 PE=1 SV=2 PF00993//PF13895 Class II histocompatibility antigen, alpha domain//Immunoglobulin domain GO:0006955//GO:0031295//GO:0019882//GO:0060333//GO:0019886//GO:0050852 immune response//T cell costimulation//antigen processing and presentation//interferon-gamma-mediated signaling pathway//antigen processing and presentation of exogenous peptide antigen via MHC class II//T cell receptor signaling pathway GO:0032395//GO:0005515 MHC class II receptor activity//protein binding GO:0005887//GO:0012507//GO:0032588//GO:0071556//GO:0042613//GO:0005765//GO:0016020//GO:0010008//GO:0000139//GO:0030669 integral component of plasma membrane//ER to Golgi transport vesicle membrane//trans-Golgi network membrane//integral component of lumenal side of endoplasmic reticulum membrane//MHC class II protein complex//lysosomal membrane//membrane//endosome membrane//Golgi membrane//clathrin-coated endocytic vesicle membrane -- -- Cluster-10145.0 BP_3 5.11 0.71 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10150.0 BP_3 8.00 0.68 855 167522202 XP_001745439.1 495 2.2e-47 hypothetical protein [Monosiga brevicollis MX1]>gi|163776397|gb|EDQ90017.1| predicted protein [Monosiga brevicollis MX1] 697089544 XM_009659386.1 783 0 Verticillium dahliae VdLs.17 60S ribosomal protein L18 mRNA K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q8TFH1 526 2.3e-52 60S ribosomal protein L18-B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl1802 PE=1 SV=1 -- -- -- -- -- -- GO:0030529 intracellular ribonucleoprotein complex KOG1714 60s ribosomal protein L18 Cluster-10153.0 BP_3 2.00 2.16 327 241602464 XP_002405189.1 254 7.4e-20 signal peptidase 12kDa subunit, putative [Ixodes scapularis]>gi|215500573|gb|EEC10067.1| signal peptidase 12kDa subunit, putative, partial [Ixodes scapularis] -- -- -- -- -- K12946 SPCS1 signal peptidase complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12946 Q9VAL0 208 6.6e-16 Signal peptidase complex subunit 1 OS=Drosophila melanogaster GN=Spase12 PE=1 SV=2 PF05038//PF06645//PF06305 Cytochrome Cytochrome b558 alpha-subunit//Microsomal signal peptidase 12 kDa subunit (SPC12)//Protein of unknown function (DUF1049) GO:0006465 signal peptide processing GO:0008233//GO:0020037 peptidase activity//heme binding GO:0005887//GO:0016021//GO:0005787 integral component of plasma membrane//integral component of membrane//signal peptidase complex KOG4112 Signal peptidase subunit Cluster-10159.0 BP_3 44.40 1.58 1646 546680629 ERL90867.1 1258 1.4e-135 hypothetical protein D910_08212 [Dendroctonus ponderosae] -- -- -- -- -- K11418 HDAC11 histone deacetylase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11418 Q9GKU5 991 5.4e-106 Histone deacetylase 11 OS=Macaca fascicularis GN=HDAC11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1344 Predicted histone deacetylase Cluster-1016.0 BP_3 3.00 0.33 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10160.0 BP_3 2.00 0.64 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10168.0 BP_3 13.32 1.03 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1017.0 BP_3 2.00 0.41 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10176.0 BP_3 11.00 0.45 1463 4502681 NP_001772.1 827 1.2e-85 early activation antigen CD69 [Homo sapiens]>gi|584906|sp|Q07108.1|CD69_HUMAN RecName: Full=Early activation antigen CD69; AltName: Full=Activation inducer molecule; Short=AIM; AltName: Full=BL-AC/P26; AltName: Full=C-type lectin domain family 2 member C; AltName: Full=EA1; AltName: Full=Early T-cell activation antigen p60; AltName: Full=GP32/28; AltName: Full=Leukocyte surface antigen Leu-23; AltName: Full=MLR-3; AltName: CD_antigen=CD69>gi|12084424|pdb|1FM5|A Chain A, Crystal Structure Of Human Cd69>gi|291898|gb|AAB46359.1| early activation antigen CD69 [Homo sapiens]>gi|397939|emb|CAA80298.1| CD69 [Homo sapiens]>gi|558352|emb|CAA83017.1| early lymphocyte activation antigen CD69 [Homo sapiens]>gi|13937863|gb|AAH07037.1| CD69 molecule [Homo sapiens]>gi|29124995|gb|AAO63584.1| CD69 antigen [Homo sapiens]>gi|119616528|gb|EAW96122.1| CD69 antigen (p60, early T-cell activation antigen), isoform CRA_a [Homo sapiens]>gi|119616529|gb|EAW96123.1| CD69 antigen (p60, early T-cell activation antigen), isoform CRA_a [Homo sapiens]>gi|123992999|gb|ABM84101.1| CD69 molecule [synthetic construct]>gi|123999929|gb|ABM87473.1| CD69 molecule [synthetic construct]>gi|158257170|dbj|BAF84558.1| unnamed protein product [Homo sapiens]>gi|649099048|gb|AIC48461.1| CD69, partial [synthetic construct] 13937862 BC007037.1 1463 0 Homo sapiens CD69 molecule, mRNA (cDNA clone MGC:12409 IMAGE:3950403), complete cds K06502 CD69 CD69 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06502 Q07108 827 5.0e-87 Early activation antigen CD69 OS=Homo sapiens GN=CD69 PE=1 SV=1 -- -- GO:0007165//GO:0035690 signal transduction//cellular response to drug GO:0004888//GO:0030246 transmembrane signaling receptor activity//carbohydrate binding GO:0005887//GO:0009897 integral component of plasma membrane//external side of plasma membrane -- -- Cluster-10177.0 BP_3 1.00 0.35 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10179.0 BP_3 2.00 0.72 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10180.0 BP_3 2.00 0.44 510 330976894 AEC48730.1 797 1.3e-82 ubiquitin-conjugating enzyme E2 b [Eriocheir sinensis] 379324149 JQ011379.1 430 0 Scylla paramamosain ubiquitin-conjugating enzyme E2 (UCE) mRNA, partial cds K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P25867 781 3.7e-82 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=eff PE=2 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-10186.0 BP_3 6.00 0.45 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10187.0 BP_3 2.00 0.38 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10195.0 BP_3 29.88 0.32 4749 642917080 XP_008191110.1 1932 2.9e-213 PREDICTED: kinesin-like protein KIF18A isoform X2 [Tribolium castaneum] -- -- -- -- -- K10401 KIF18_19 kinesin family member 18/19 http://www.genome.jp/dbget-bin/www_bget?ko:K10401 Q8NI77 1056 4.5e-113 Kinesin-like protein KIF18A OS=Homo sapiens GN=KIF18A PE=1 SV=2 PF02245//PF00225//PF04923 Methylpurine-DNA glycosylase (MPG)//Kinesin motor domain//Ninjurin GO:0007017//GO:0007155//GO:0007018//GO:0006284//GO:0042246 microtubule-based process//cell adhesion//microtubule-based movement//base-excision repair//tissue regeneration GO:0008017//GO:0005524//GO:0003677//GO:0003905//GO:0003777 microtubule binding//ATP binding//DNA binding//alkylbase DNA N-glycosylase activity//microtubule motor activity GO:0016021//GO:0005874//GO:0045298 integral component of membrane//microtubule//tubulin complex KOG0242 Kinesin-like protein Cluster-1020.0 BP_3 1.00 0.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02701 Dof domain, zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-10205.0 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03824 High-affinity nickel-transport protein GO:0035444//GO:0015675 nickel cation transmembrane transport//nickel cation transport GO:0015099//GO:0046872 nickel cation transmembrane transporter activity//metal ion binding GO:0016021 integral component of membrane -- -- Cluster-1021.0 BP_3 4.00 1.79 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10217.1 BP_3 3.00 0.42 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1022.0 BP_3 6.00 0.59 780 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10236.0 BP_3 3.00 0.59 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10241.0 BP_3 9.80 0.73 941 270003224 EEZ99671.1 224 6.5e-16 hypothetical protein TcasGA2_TC002428 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF01777 Ligand-gated ion channel//Ribosomal L27e protein family GO:0006412//GO:0007268//GO:0007165//GO:0006811//GO:0042254 translation//synaptic transmission//signal transduction//ion transport//ribosome biogenesis GO:0004970//GO:0003735 ionotropic glutamate receptor activity//structural constituent of ribosome GO:0016020//GO:0005622//GO:0005840 membrane//intracellular//ribosome -- -- Cluster-10242.0 BP_3 2.00 0.34 575 -- -- -- -- -- 313760628 NM_001199573.1 575 0 Homo sapiens tripartite motif containing 22 (TRIM22), transcript variant 2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10244.0 BP_3 3.00 0.40 657 241829658 XP_002414770.1 346 3.2e-30 brahma/SWI2-related protein BRG-1 [Ixodes scapularis]>gi|215508982|gb|EEC18435.1| brahma/SWI2-related protein BRG-1 [Ixodes scapularis] 347966576 XM_321283.5 36 2.77681e-07 Anopheles gambiae str. PEST AGAP001786-PA (AgaP_AGAP001786) mRNA, complete cds K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 287 9.2e-25 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-10245.0 BP_3 2.00 0.62 448 414453458 AFX00006.1 203 8.4e-14 GTP-binding nuclear protein Ran [Mnemiopsis leidyi] 697084328 XM_009656871.1 445 0 Verticillium dahliae VdLs.17 GTP-binding nuclear protein GSP1/Ran mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 Q7RVL0 255 3.2e-21 GTP-binding nuclear protein GSP1/Ran OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=ran PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-10264.0 BP_3 2.00 0.44 510 -- -- -- -- -- 768311752 CP010980.1 510 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10269.0 BP_3 4.00 1.04 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10283.0 BP_3 5.00 0.37 946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10285.0 BP_3 1.00 0.54 378 871248769 XP_005103573.2 229 6.9e-17 PREDICTED: scavenger receptor class B member 1-like [Aplysia californica] -- -- -- -- -- K12384 SCARB2, LIMP2, CD36L2 lysosome membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12384 Q14108 210 4.5e-16 Lysosome membrane protein 2 OS=Homo sapiens GN=SCARB2 PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-10286.0 BP_3 14.00 0.33 2329 514258350 AGO46415.1 1179 2.9e-126 succinate dehydrogenase complex subunit A, partial [Reticulitermes flavipes] 699631991 XM_009909805.1 249 4.01298e-125 PREDICTED: Picoides pubescens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA K00235 SDHB, SDH2 succinate dehydrogenase (ubiquinone) iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00235 P21914 1121 6.4e-121 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Drosophila melanogaster GN=SdhB PE=2 SV=2 PF13085//PF00111 2Fe-2S iron-sulfur cluster binding domain//2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0051536//GO:0009055 iron-sulfur cluster binding//electron carrier activity -- -- KOG3049 Succinate dehydrogenase, Fe-S protein subunit Cluster-10288.0 BP_3 4.00 0.54 646 270000947 EEZ97394.1 469 1.7e-44 hypothetical protein TcasGA2_TC011220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 373 9.6e-35 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-10297.0 BP_3 9.00 0.40 1381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-103.0 BP_3 8.00 1.39 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10324.0 BP_3 3.00 0.73 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10325.0 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10334.0 BP_3 4.00 0.50 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10338.0 BP_3 13.00 2.68 525 558200952 XP_006131500.1 140 2.0e-06 PREDICTED: cytochrome c oxidase subunit 7A2, mitochondrial-like [Pelodiscus sinensis] 262401022 FJ774692.1 502 0 Scylla paramamosain cytochrome c oxidase subunit VIIA putative mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10339.0 BP_3 3.00 0.34 719 270014867 EFA11315.1 679 8.6e-69 hypothetical protein TcasGA2_TC010854 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3N2 469 7.9e-46 EF-hand calcium-binding domain-containing protein 1 OS=Mus musculus GN=Efcab1 PE=2 SV=1 PF13833//PF00036//PF13405//PF13499//PF13202 EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-10340.3 BP_3 6.00 0.49 879 641673178 XP_008186225.1 178 1.3e-10 PREDICTED: LOW QUALITY PROTEIN: G-box-binding factor [Acyrthosiphon pisum] -- -- -- -- -- K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 -- -- -- -- PF09726//PF00170 Transmembrane protein//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-10346.0 BP_3 19.00 1.14 1092 34365139 CAE45921.1 1711 2.8e-188 hypothetical protein [Homo sapiens] 49258099 BC073765.1 1050 0 Homo sapiens immunoglobulin heavy constant alpha 2 (A2m marker), mRNA (cDNA clone IMAGE:4765168) K06856 IGH immunoglobulin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K06856 P01877 1673 3.0e-185 Ig alpha-2 chain C region OS=Homo sapiens GN=IGHA2 PE=1 SV=3 PF13895//PF09085 Immunoglobulin domain//Adhesion molecule, immunoglobulin-like GO:0007155 cell adhesion GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-10346.1 BP_3 5.00 1.42 461 34529114 BAC85640.1 641 1.4e-64 unnamed protein product [Homo sapiens] 34527232 AK130433.1 426 0 Homo sapiens cDNA FLJ26923 fis, clone RCT04885, highly similar to Ig alpha-1 chain C region K06856 IGH immunoglobulin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K06856 P01876 514 3.1e-51 Ig alpha-1 chain C region OS=Homo sapiens GN=IGHA1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-10347.0 BP_3 10.00 0.70 983 -- -- -- -- -- 697075246 XM_009653737.1 768 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10353.1 BP_3 2.00 0.46 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10359.0 BP_3 11.97 0.64 1199 642935674 XP_974741.2 529 3.5e-51 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9S1 419 8.3e-40 Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Drosophila melanogaster GN=blos1 PE=1 SV=2 PF06320 GCN5-like protein 1 (GCN5L1) -- -- -- -- GO:0031083 BLOC-1 complex KOG3390 General control of amino-acid synthesis 5-like 1 Cluster-10363.0 BP_3 3.00 0.73 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10367.0 BP_3 2.00 0.43 517 321460438 EFX71480.1 417 1.5e-38 nucleolar protein-like protein 5A [Daphnia pulex] -- -- -- -- -- K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q9D6Z1 334 2.6e-30 Nucleolar protein 56 OS=Mus musculus GN=Nop56 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-10374.0 BP_3 2.00 2.24 325 -- -- -- -- -- 768311758 CP010986.1 316 2.90693e-163 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10376.0 BP_3 38.00 1.61 1427 270006387 EFA02835.1 929 1.8e-97 hypothetical protein TcasGA2_TC007536 [Tribolium castaneum] 871223279 XM_013080795.1 39 1.33312e-08 PREDICTED: Aplysia californica cholecystokinin receptor-like (LOC101846804), mRNA K04196 CCKLR cholecystokinin-like receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04196 P70031 403 7.1e-38 Cholecystokinin receptor OS=Xenopus laevis GN=cckar PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-10381.0 BP_3 1.00 0.33 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10385.0 BP_3 1.00 0.58 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10387.0 BP_3 1.00 0.99 332 410825534 AFV91538.1 176 8.4e-11 B-type preproallatostatin I, partial [Pandalopsis japonica] -- -- -- -- -- -- -- -- -- P82003 124 3.7e-06 Prothoracicostatic peptide OS=Bombyx mori PE=1 SV=2 PF06377 Adipokinetic hormone GO:0007165 signal transduction GO:0005179 hormone activity -- -- -- -- Cluster-10390.0 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10395.0 BP_3 1.00 5.36 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10398.0 BP_3 28.82 0.78 2076 642917255 XP_008199223.1 1249 2.0e-134 PREDICTED: coiled-coil and C2 domain-containing protein 2A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CFW7 552 5.4e-55 Coiled-coil and C2 domain-containing protein 2A OS=Mus musculus GN=Cc2d2a PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-104.0 BP_3 7.00 1.20 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10402.0 BP_3 30.00 0.93 1842 478259621 ENN79474.1 466 1.1e-43 hypothetical protein YQE_04118, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-1041.0 BP_3 3.00 2.28 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10415.0 BP_3 2.00 0.33 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10416.0 BP_3 2.00 0.35 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10429.0 BP_3 2.00 0.52 478 -- -- -- -- -- 768311754 CP010982.1 466 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- Q870L2 222 2.3e-17 Siderophore iron transporter mirB OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=mirB PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10430.0 BP_3 6.00 0.42 979 544512774 XP_005589973.1 992 5.9e-105 PREDICTED: 60S ribosomal protein L13a isoform X1 [Macaca fascicularis]>gi|635040461|ref|XP_007995756.1| PREDICTED: 60S ribosomal protein L13a isoform X1 [Chlorocebus sabaeus] 395132448 NM_012423.3 979 0 Homo sapiens ribosomal protein L13a (RPL13A), transcript variant 1, mRNA K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 P40429 974 3.0e-104 60S ribosomal protein L13a OS=Homo sapiens GN=RPL13A PE=1 SV=2 PF00572 Ribosomal protein L13 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-10435.0 BP_3 4.00 0.38 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-10439.1 BP_3 17.63 0.82 1326 642933705 XP_974874.3 967 6.4e-102 PREDICTED: protein OSCP1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHW2 295 2.2e-25 Protein OSCP1 OS=Mus musculus GN=Oscp1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10445.0 BP_3 6.00 0.34 1153 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10449.0 BP_3 5.31 0.31 1114 478266693 ENN82870.1 474 7.9e-45 hypothetical protein YQE_00763, partial [Dendroctonus ponderosae]>gi|546684080|gb|ERL93799.1| hypothetical protein D910_11085 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TEA1 227 1.4e-17 Putative methyltransferase NSUN6 OS=Homo sapiens GN=NSUN6 PE=1 SV=1 PF01472 PUA domain -- -- GO:0003723 RNA binding -- -- KOG1122 tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) Cluster-10451.0 BP_3 5.00 0.74 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10453.1 BP_3 3.00 0.72 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-10461.0 BP_3 5.00 0.35 975 831783402 XP_012757037.1 238 1.6e-17 hypothetical protein SAMD00019534_022850 [Acytostelium subglobosum LB1]>gi|735857669|dbj|GAM19110.1| hypothetical protein SAMD00019534_022850 [Acytostelium subglobosum LB1] 697081950 XM_009656042.1 909 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- P55023 167 1.1e-10 Tyrosinase OS=Streptomyces lincolnensis GN=melC2 PE=3 SV=2 PF00264 Common central domain of tyrosinase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-10461.1 BP_3 1.00 4.87 264 -- -- -- -- -- 768311756 CP010984.1 261 8.62969e-133 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10463.0 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-10465.0 BP_3 3.00 2.05 358 642925502 XP_008194577.1 217 1.6e-15 PREDICTED: immediate early response 3-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CR20 136 1.6e-07 Immediate early response 3-interacting protein 1 OS=Mus musculus GN=Ier3ip1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10466.0 BP_3 1.00 0.98 333 369724800 AEX20235.1 315 6.4e-27 pacifastin-related serine protease inhibitor [Portunus trituberculatus] 385270634 JF827348.1 203 1.95671e-100 Portunus trituberculatus pacifastin-like serine protease inhibitor (PLC3) mRNA, partial cds -- -- -- -- -- -- -- -- PF00093//PF05375 von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) -- -- GO:0030414//GO:0005515 peptidase inhibitor activity//protein binding -- -- -- -- Cluster-10468.0 BP_3 9.00 0.53 1104 826502136 XP_012542232.1 192 3.9e-12 PREDICTED: pro-resilin-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- Q9V7U0 147 2.7e-08 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF06455//PF01299//PF01213//PF00379 NADH dehydrogenase subunit 5 C-terminus//Lysosome-associated membrane glycoprotein (Lamp)//Adenylate cyclase associated (CAP) N terminal//Insect cuticle protein GO:0006744//GO:0006814//GO:0055114//GO:0015992//GO:0006120//GO:0042773//GO:0007010 ubiquinone biosynthetic process//sodium ion transport//oxidation-reduction process//proton transport//mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled electron transport//cytoskeleton organization GO:0008137//GO:0042302//GO:0003779 NADH dehydrogenase (ubiquinone) activity//structural constituent of cuticle//actin binding GO:0016020 membrane -- -- Cluster-10470.0 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10474.0 BP_3 8.00 0.38 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10474.1 BP_3 1.00 0.54 378 642913543 XP_971895.2 141 1.1e-06 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10475.0 BP_3 6.00 0.53 835 378556263 AFC17961.1 715 6.7e-73 O-methyltransferase [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- Q86IC8 394 4.6e-37 Probable caffeoyl-CoA O-methyltransferase 2 OS=Dictyostelium discoideum GN=omt6 PE=1 SV=1 PF01596//PF01209 O-methyltransferase//ubiE/COQ5 methyltransferase family -- -- GO:0008168//GO:0008171 methyltransferase activity//O-methyltransferase activity -- -- KOG1663 O-methyltransferase Cluster-1053.0 BP_3 3.53 0.60 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10535.0 BP_3 131.00 1.68 4044 189240996 XP_001809953.1 1137 3.8e-121 PREDICTED: calponin homology domain-containing protein DDB_G0272472 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90YK5 154 1.5e-08 Heparanase OS=Gallus gallus GN=HPSE PE=1 SV=1 PF03118 Bacterial RNA polymerase, alpha chain C terminal domain GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-10538.0 BP_3 3.00 1.47 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10540.0 BP_3 3.00 0.35 700 556991284 XP_006000240.1 727 2.3e-74 PREDICTED: protein mab-21-like 1 [Latimeria chalumnae] 675895155 KJ670371.1 123 1.28676e-55 Miniopterus fuliginosus Mab-21-like 2 (Mab21l2) mRNA, complete cds -- -- -- -- Q13394 721 4.6e-75 Protein mab-21-like 1 OS=Homo sapiens GN=MAB21L1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-10544.0 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1055.0 BP_3 2.00 0.50 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10551.0 BP_3 5.00 1.47 455 642913859 XP_008201191.1 174 2.0e-10 PREDICTED: uncharacterized protein LOC103315111 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10554.0 BP_3 1.00 1.49 310 -- -- -- -- -- 48958545 AC146338.2 307 2.77718e-158 Oryza sativa Japonica Group chromosome 5 clone OSJNBa0093C16, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10558.0 BP_3 2.00 0.35 569 694542644 XP_009497389.1 380 3.2e-34 hypothetical protein H696_05252 [Fonticula alba]>gi|627946322|gb|KCV68335.1| hypothetical protein H696_05252 [Fonticula alba] 768311754 CP010982.1 566 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence K01537 E3.6.3.8 Ca2+-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01537 P22189 441 1.1e-42 Calcium-transporting ATPase 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cta3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0204 Calcium transporting ATPase Cluster-1056.0 BP_3 1.00 0.40 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10567.0 BP_3 2.00 0.32 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-10568.1 BP_3 3.00 0.61 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10573.0 BP_3 4.00 0.68 576 514695405 XP_004995273.1 212 9.7e-15 60S acidic ribosomal protein P1 [Salpingoeca rosetta]>gi|326437339|gb|EGD82909.1| 60S acidic ribosomal protein P1 [Salpingoeca rosetta] 697069444 XM_009651611.1 558 0 Verticillium dahliae VdLs.17 60S acidic ribosomal protein P1 mRNA K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P50344 274 2.6e-23 60S acidic ribosomal protein P1 OS=Davidiella tassiana GN=CLAH12 PE=1 SV=1 PF01213 Adenylate cyclase associated (CAP) N terminal GO:0042254//GO:0007010//GO:0006414 ribosome biogenesis//cytoskeleton organization//translational elongation GO:0003779//GO:0003735 actin binding//structural constituent of ribosome GO:0005840 ribosome KOG1762 60s acidic ribosomal protein P1 Cluster-10578.0 BP_3 6.00 0.67 725 291242137 XP_002740964.1 830 2.7e-86 PREDICTED: ADP-ribosylation factor 1-like isoform X3 [Saccoglossus kowalevskii]>gi|291242139|ref|XP_002740965.1| PREDICTED: ADP-ribosylation factor 1-like isoform X4 [Saccoglossus kowalevskii]>gi|585709105|ref|XP_006824295.1| PREDICTED: ADP-ribosylation factor 1-like isoform X5 [Saccoglossus kowalevskii]>gi|585709112|ref|XP_006824296.1| PREDICTED: ADP-ribosylation factor 1-like isoform X6 [Saccoglossus kowalevskii] 697067848 XM_009650814.1 722 0 Verticillium dahliae VdLs.17 ADP-ribosylation factor mRNA K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 P34727 883 7.9e-94 ADP-ribosylation factor OS=Ajellomyces capsulatus GN=ARF PE=1 SV=3 PF01926//PF08477//PF00071//PF04670//PF00025//PF01591//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ras family//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//6-phosphofructo-2-kinase//G-protein alpha subunit GO:0007186//GO:0007264//GO:0006013//GO:0006000//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//mannose metabolic process//fructose metabolic process//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0005524//GO:0031683//GO:0003873//GO:0003924 GTP binding//signal transducer activity//guanyl nucleotide binding//ATP binding//G-protein beta/gamma-subunit complex binding//6-phosphofructo-2-kinase activity//GTPase activity -- -- KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-10579.0 BP_3 2.00 1.20 369 126697458 ABO26686.1 146 2.8e-07 40S ribosomal protein S18 [Haliotis discus discus]>gi|363894932|gb|AEW42983.1| putative 40S ribosomal protein S18 [Haliotis diversicolor] 768311755 CP010983.1 315 1.20306e-162 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- P34788 157 6.1e-10 40S ribosomal protein S18 OS=Arabidopsis thaliana GN=RPS18A PE=1 SV=1 PF00416 Ribosomal protein S13/S18 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG3311 Ribosomal protein S18 Cluster-10579.1 BP_3 2.00 0.67 436 156372342 XP_001628997.1 511 1.6e-49 predicted protein [Nematostella vectensis]>gi|156215987|gb|EDO36934.1| predicted protein [Nematostella vectensis] 697079366 XM_009655153.1 436 0 Verticillium dahliae VdLs.17 40S ribosomal protein S18 mRNA K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 P0CX56 521 4.5e-52 40S ribosomal protein S18-B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPS18B PE=1 SV=1 PF00416 Ribosomal protein S13/S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005622//GO:0005840 intracellular//ribosome KOG3311 Ribosomal protein S18 Cluster-10586.0 BP_3 2.00 0.53 473 328725320 XP_003248428.1 145 4.7e-07 PREDICTED: uncharacterized protein LOC100571337 [Acyrthosiphon pisum] 697087797 XM_009658515.1 374 0 Verticillium dahliae VdLs.17 lysozyme partial mRNA -- -- -- -- -- -- -- -- PF00959 Phage lysozyme GO:0016998//GO:0009253//GO:0005975 cell wall macromolecule catabolic process//peptidoglycan catabolic process//carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-10588.0 BP_3 13.00 0.46 1643 751773601 XP_011213405.1 1921 1.9e-212 PREDICTED: NADH-ubiquinone oxidoreductase 49 kDa subunit [Bactrocera dorsalis] 641722986 XM_008153074.1 260 2.1592e-131 PREDICTED: Eptesicus fuscus NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) (NDUFS2), mRNA K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q641Y2 1781 1.3e-197 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Rattus norvegicus GN=Ndufs2 PE=1 SV=1 PF00374//PF00346 Nickel-dependent hydrogenase//Respiratory-chain NADH dehydrogenase, 49 Kd subunit GO:0055114 oxidation-reduction process GO:0048038//GO:0051287//GO:0016151//GO:0016651 quinone binding//NAD binding//nickel cation binding//oxidoreductase activity, acting on NAD(P)H -- -- KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-1059.0 BP_3 3.00 1.06 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10594.0 BP_3 16.00 0.59 1588 642927592 XP_008195328.1 1586 1.3e-173 PREDICTED: cyclin-dependent kinase-like 4 isoform X3 [Tribolium castaneum] 844839798 XM_012937545.1 64 1.88356e-22 Schistosoma haematobium Cyclin-dependent kinase-like 1 mRNA K08824 CDKL cyclin-dependent kinase-like http://www.genome.jp/dbget-bin/www_bget?ko:K08824 Q00532 1129 5.2e-122 Cyclin-dependent kinase-like 1 OS=Homo sapiens GN=CDKL1 PE=1 SV=5 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0593 Predicted protein kinase KKIAMRE Cluster-10595.0 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-106.0 BP_3 6.00 0.45 930 546675956 ERL87051.1 200 3.9e-13 hypothetical protein D910_04452 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P27780 174 1.7e-11 Pupal cuticle protein Edg-84A OS=Drosophila melanogaster GN=Edg84A PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-10600.0 BP_3 4.00 0.94 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10601.1 BP_3 1.00 0.35 429 241998476 XP_002433881.1 214 4.3e-15 O-linked N-acetylglucosamine transferase, OGT, putative [Ixodes scapularis]>gi|215495640|gb|EEC05281.1| O-linked N-acetylglucosamine transferase, OGT, putative, partial [Ixodes scapularis] -- -- -- -- -- -- -- -- -- Q6DCD5 165 8.4e-11 Transmembrane and TPR repeat-containing protein 2 OS=Xenopus laevis GN=tmtc2 PE=2 SV=1 PF07721//PF13181//PF03127//PF13371//PF13374//PF00515//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//GAT domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0006886 intracellular protein transport GO:0005515//GO:0042802 protein binding//identical protein binding GO:0005622 intracellular KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-10602.0 BP_3 2.00 0.32 590 806629239 AKB96223.1 762 1.7e-78 heat shock protein [Cherax quadricarinatus] 688595498 XM_685413.6 45 2.46071e-12 PREDICTED: Danio rerio si:dkey-21a6.6 (si:dkey-21a6.6), mRNA K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q61316 457 1.6e-44 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-10609.0 BP_3 3.00 0.32 740 646713547 KDR17851.1 551 6.2e-54 ADIPOR-like receptor, partial [Zootermopsis nevadensis] 594660903 XM_007178642.1 48 6.71582e-14 PREDICTED: Balaenoptera acutorostrata scammoni adiponectin receptor 2 (ADIPOR2), mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 532 4.0e-53 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-1061.0 BP_3 2.00 0.57 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10610.0 BP_3 4.00 0.34 851 807015728 XP_012156426.1 622 4.1e-62 PREDICTED: uncharacterized protein LOC101460284 [Ceratitis capitata] -- -- -- -- -- K15297 RIMS2, RIM2 regulating synaptic membrane exocytosis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15297 Q86UR5 501 1.8e-49 Regulating synaptic membrane exocytosis protein 1 OS=Homo sapiens GN=RIMS1 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG2060 Rab3 effector RIM1 and related proteins, contain PDZ and C2 domains Cluster-10611.0 BP_3 4.00 0.38 801 170028910 XP_001842337.1 610 9.6e-61 cathepsin L [Culex quinquefasciatus]>gi|167879387|gb|EDS42770.1| cathepsin L [Culex quinquefasciatus] -- -- -- -- -- K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 516 3.1e-51 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF00112//PF08127 Papain family cysteine protease//Peptidase family C1 propeptide GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197//GO:0008233 cysteine-type peptidase activity//cysteine-type endopeptidase activity//peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-10613.0 BP_3 2.00 0.44 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10615.0 BP_3 4.00 0.97 490 256539088 ACU82846.1 392 1.1e-35 acyl-CoA-binding protein [Fenneropenaeus chinensis] 198473999 XM_001356482.2 34 2.63575e-06 Drosophila pseudoobscura pseudoobscura GA21120 (Dpse\GA21120), partial mRNA K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) http://www.genome.jp/dbget-bin/www_bget?ko:K08762 P45883 323 4.6e-29 Acyl-CoA-binding protein homolog OS=Pelophylax ridibundus PE=1 SV=2 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-10618.0 BP_3 9.00 0.68 934 332373158 AEE61720.1 640 3.7e-64 unknown [Dendroctonus ponderosae] 768311759 CP010987.1 892 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 P34227 641 1.2e-65 Mitochondrial peroxiredoxin PRX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRX1 PE=1 SV=1 PF00578//PF08534//PF10417 AhpC/TSA family//Redoxin//C-terminal domain of 1-Cys peroxiredoxin GO:0055114 oxidation-reduction process GO:0051920//GO:0016209//GO:0016491 peroxiredoxin activity//antioxidant activity//oxidoreductase activity -- -- KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-10619.0 BP_3 5.00 0.43 854 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10628.0 BP_3 8.00 0.42 1215 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10629.0 BP_3 25.00 10.18 409 268306418 ACY95330.1 484 2.0e-46 ribosomal protein L31 [Manduca sexta] 317143691 XM_003189479.1 54 1.65286e-17 Aspergillus oryzae RIB40 60S ribosomal protein L31, partial mRNA K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 Q9GP16 481 1.8e-47 60S ribosomal protein L31 OS=Heliothis virescens GN=RpL31 PE=2 SV=1 PF01198//PF09618 Ribosomal protein L31e//CRISPR-associated protein (Cas_Csy4) GO:0042254//GO:0006412//GO:0043571 ribosome biogenesis//translation//maintenance of CRISPR repeat elements GO:0004519//GO:0003735 endonuclease activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0893 60S ribosomal protein L31 Cluster-10632.0 BP_3 29.00 1.26 1403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10633.1 BP_3 2.00 0.36 559 470526946 XP_004356840.1 280 1.2e-22 transporter, major facilitator superfamily superfamily protein [Acanthamoeba castellanii str. Neff]>gi|440804057|gb|ELR24940.1| transporter, major facilitator superfamily superfamily protein [Acanthamoeba castellanii str. Neff] 615475553 XM_007602397.1 165 4.55525e-79 Colletotrichum fioriniae PJ7 hypothetical protein mRNA -- -- -- -- Q9P3U6 441 1.1e-42 High-affinity glucose transporter ght1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ght1 PE=1 SV=1 PF00083//PF07690//PF06027 Sugar (and other) transporter//Major Facilitator Superfamily//Solute carrier family 35 GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-10637.0 BP_3 19.00 2.36 680 302136424 ADK94169.1 797 1.7e-82 nucleoside diphosphate kinase [Eriocheir sinensis] 262401098 FJ774730.1 563 0 Scylla paramamosain oncoprotein nm23 mRNA, partial cds K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 P19804 619 3.0e-63 Nucleoside diphosphate kinase B OS=Rattus norvegicus GN=Nme2 PE=1 SV=1 PF04505//PF00334 Interferon-induced transmembrane protein//Nucleoside diphosphate kinase GO:0006144//GO:0006183//GO:0006228//GO:0009607//GO:0006165//GO:0006206//GO:0006241 purine nucleobase metabolic process//GTP biosynthetic process//UTP biosynthetic process//response to biotic stimulus//nucleoside diphosphate phosphorylation//pyrimidine nucleobase metabolic process//CTP biosynthetic process GO:0004550 nucleoside diphosphate kinase activity GO:0016021 integral component of membrane KOG0888 Nucleoside diphosphate kinase Cluster-10647.0 BP_3 11.00 0.46 1440 347969423 XP_312882.5 1428 2.4e-155 AGAP003184-PA [Anopheles gambiae str. PEST]>gi|333468517|gb|EAA08478.5| AGAP003184-PA [Anopheles gambiae str. PEST] 338224431 HM217861.1 403 0 Scylla paramamosain 5-aminolevulinic acid synthase mRNA, partial cds K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 Q3ZC31 1250 4.4e-136 5-aminolevulinate synthase, erythroid-specific, mitochondrial OS=Bos taurus GN=ALAS2 PE=2 SV=1 PF01053//PF00155 Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II GO:0006563//GO:0033014//GO:0042967//GO:0006566//GO:0006544//GO:0006783//GO:0009058 L-serine metabolic process//tetrapyrrole biosynthetic process//acyl-carrier-protein biosynthetic process//threonine metabolic process//glycine metabolic process//heme biosynthetic process//biosynthetic process GO:0030170//GO:0003870 pyridoxal phosphate binding//5-aminolevulinate synthase activity -- -- KOG1360 5-aminolevulinate synthase Cluster-10653.0 BP_3 9.00 0.62 990 330827280 XP_003291772.1 207 6.4e-14 hypothetical protein DICPUDRAFT_156413 [Dictyostelium purpureum]>gi|325078031|gb|EGC31706.1| hypothetical protein DICPUDRAFT_156413 [Dictyostelium purpureum] 768311756 CP010984.1 978 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- P87216 400 1.1e-37 Protein vip1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=vip1 PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- -- -- Cluster-10657.0 BP_3 2.00 0.31 603 795126095 XP_011789589.1 253 1.8e-19 PREDICTED: regulator of G-protein signaling 1 [Colobus angolensis palliatus] 56682943 NM_002922.3 603 0 Homo sapiens regulator of G-protein signaling 1 (RGS1), mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q08116 253 7.4e-21 Regulator of G-protein signaling 1 OS=Homo sapiens GN=RGS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-10690.0 BP_3 1.00 0.38 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10695.0 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10697.0 BP_3 1.00 0.38 417 -- -- -- -- -- 761231856 KM881642.1 417 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C506 391 5.1e-37 DNA-directed RNA polymerase subunit beta' OS=Oryza sativa subsp. japonica GN=rpoC1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10698.0 BP_3 19.76 0.32 3244 270000737 EEZ97184.1 998 4.0e-105 hypothetical protein TcasGA2_TC004371 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14AW5 137 1.1e-06 Putative methyltransferase NSUN7 OS=Mus musculus GN=Nsun7 PE=2 SV=2 PF09019 EcoRII C terminal GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-10700.0 BP_3 2.00 0.52 476 -- -- -- -- -- 768311759 CP010987.1 473 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- Q4IQ08 488 3.3e-48 GPI-anchored wall transfer protein 1 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) GN=GWT1 PE=3 SV=1 PF06423 GWT1 GO:0006506 GPI anchor biosynthetic process GO:0016746 transferase activity, transferring acyl groups GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-10707.0 BP_3 17.45 1.23 974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10724.0 BP_3 4.00 0.49 684 795603551 XP_011727341.1 1124 2.1e-120 PREDICTED: proteasome subunit beta type-8 isoform X2 [Macaca nemestrina] 73747874 NM_148919.3 684 0 Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (PSMB8), transcript variant 2, mRNA K02740 PSMB8, LMP7 20S proteasome subunit beta 8 http://www.genome.jp/dbget-bin/www_bget?ko:K02740 P28062 1146 2.4e-124 Proteasome subunit beta type-8 OS=Homo sapiens GN=PSMB8 PE=1 SV=3 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0175 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 Cluster-10733.0 BP_3 2.00 0.46 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10744.0 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10746.0 BP_3 3.00 1.02 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04664 Opioid growth factor receptor (OGFr) conserved region GO:0007165 signal transduction GO:0004872 receptor activity GO:0016020 membrane -- -- Cluster-10755.0 BP_3 1.00 0.88 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10766.0 BP_3 1.00 0.43 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus -- -- Cluster-10772.0 BP_3 4.00 1.50 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10773.0 BP_3 13.00 1.05 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05132//PF04931//PF04147//PF01080//PF14721//PF04546//PF04194//PF03896//PF02535//PF04006//PF03985//PF02724 RNA polymerase III RPC4//DNA polymerase phi//Nop14-like family//Presenilin//Apoptosis-inducing factor, mitochondrion-associated, C-term//Sigma-70, non-essential region//Programmed cell death protein 2, C-terminal putative domain//Translocon-associated protein (TRAP), alpha subunit//ZIP Zinc transporter//Mpp10 protein//Paf1//CDC45-like protein GO:0055085//GO:0006270//GO:0016570//GO:0006260//GO:0006383//GO:0006364//GO:0006355//GO:0030001//GO:0006351//GO:0006368//GO:0006144//GO:0006206//GO:0006352 transmembrane transport//DNA replication initiation//histone modification//DNA replication//transcription from RNA polymerase III promoter//rRNA processing//regulation of transcription, DNA-templated//metal ion transport//transcription, DNA-templated//transcription elongation from RNA polymerase II promoter//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//DNA-templated transcription, initiation GO:0003700//GO:0004190//GO:0003887//GO:0046983//GO:0016987//GO:0046873//GO:0003899//GO:0003677 transcription factor activity, sequence-specific DNA binding//aspartic-type endopeptidase activity//DNA-directed DNA polymerase activity//protein dimerization activity//sigma factor activity//metal ion transmembrane transporter activity//DNA-directed RNA polymerase activity//DNA binding GO:0005666//GO:0005730//GO:0005667//GO:0005732//GO:0034457//GO:0016593//GO:0016021//GO:0042575//GO:0005737//GO:0032040//GO:0005789//GO:0005634//GO:0016020 DNA-directed RNA polymerase III complex//nucleolus//transcription factor complex//small nucleolar ribonucleoprotein complex//Mpp10 complex//Cdc73/Paf1 complex//integral component of membrane//DNA polymerase complex//cytoplasm//small-subunit processome//endoplasmic reticulum membrane//nucleus//membrane -- -- Cluster-10778.1 BP_3 14.88 0.36 2282 -- -- -- -- -- 338224420 HM217854.1 258 3.90305e-130 Scylla paramamosain retinitis pigmentosa GTPase regulator-like protein-like protein-like mRNA, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10785.0 BP_3 1.00 0.32 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10791.0 BP_3 2.00 0.34 576 829755793 XP_012618011.1 268 3.1e-21 PREDICTED: anaphase-promoting complex subunit 16 isoform X1 [Microcebus murinus] 335892805 NR_038392.1 573 0 Homo sapiens anaphase promoting complex subunit 16 (ANAPC16), transcript variant 6, non-coding RNA -- -- -- -- Q58DR0 268 1.3e-22 Anaphase-promoting complex subunit 16 OS=Bos taurus GN=ANAPC16 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10792.0 BP_3 2.00 0.55 467 646692962 KDR07589.1 273 6.7e-22 Forkhead box protein P4 [Zootermopsis nevadensis] -- -- -- -- -- K09409 FOXP forkhead box protein P http://www.genome.jp/dbget-bin/www_bget?ko:K09409 Q8MJ98 185 4.4e-13 Forkhead box protein P2 OS=Pongo pygmaeus GN=FOXP2 PE=2 SV=3 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-10797.0 BP_3 3.00 0.47 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-108.0 BP_3 1.00 1.40 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10814.0 BP_3 3.00 0.45 613 299829164 YP_003735174.1 609 9.6e-61 cytochrome c oxidase subunit III [Apis cerana]>gi|238800121|gb|ACR55913.1| cytochrome c oxidase subunit III [Apis cerana]>gi|702076551|gb|AIW06353.1| cytochrome c oxidase subunit III (mitochondrion) [Apis cerana] 702076545 KM244704.1 604 0 Apis cerana isolate CL24 mitochondrion, partial genome K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 P34843 490 2.5e-48 Cytochrome c oxidase subunit 3 OS=Apis mellifera ligustica GN=COIII PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-10815.2 BP_3 18.00 0.48 2110 642927152 XP_008195159.1 574 3.8e-56 PREDICTED: uncharacterized protein LOC103313501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10818.0 BP_3 3.00 0.39 667 328899359 AEB54635.1 933 2.8e-98 eukaryotic translation initiation factor 3 subunit 12 [Procambarus clarkii] -- -- -- -- -- K15028 EIF3K translation initiation factor 3 subunit K http://www.genome.jp/dbget-bin/www_bget?ko:K15028 Q6GNI4 721 4.4e-75 Eukaryotic translation initiation factor 3 subunit K OS=Xenopus laevis GN=eif3k PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3252 Uncharacterized conserved protein Cluster-10821.0 BP_3 3.00 0.39 660 780012564 XP_781796.2 383 1.7e-34 PREDICTED: uncharacterized protein LOC576388 [Strongylocentrotus purpuratus] 697079697 XM_009655268.1 660 0 Verticillium dahliae VdLs.17 histone H4.2 mRNA K11254 H4 histone H4 http://www.genome.jp/dbget-bin/www_bget?ko:K11254 P27996 380 1.5e-35 Histone H4 OS=Solaster stimpsoni PE=3 SV=2 PF02969//PF00125//PF02291 TATA box binding protein associated factor (TAF)//Core histone H2A/H2B/H3/H4//Transcription initiation factor IID, 31kD subunit GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-10826.0 BP_3 3.00 1.11 421 262401159 ACY66482.1 413 3.5e-38 NADH:ubiquinone dehydrogenase [Scylla paramamosain] 262401158 FJ774761.1 306 1.39911e-157 Scylla paramamosain NADH:ubiquinone dehydrogenase mRNA, partial cds K03960 NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03960 -- -- -- -- PF07225 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0015992//GO:0006814//GO:0006744//GO:0006120 proton transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion -- -- Cluster-10828.0 BP_3 2.00 0.32 590 321468064 EFX79051.1 257 6.0e-20 hypothetical protein DAPPUDRAFT_52830, partial [Daphnia pulex] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 215 1.8e-16 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10836.2 BP_3 16.00 0.76 1305 470427696 XP_004338018.1 185 3.0e-11 serine rich protein [Acanthamoeba castellanii str. Neff]>gi|440794860|gb|ELR16005.1| serine rich protein [Acanthamoeba castellanii str. Neff] 768311759 CP010987.1 1271 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10845.0 BP_3 1.00 1.37 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1085.0 BP_3 3.00 0.93 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10850.0 BP_3 4.00 0.37 811 755785705 XP_003995546.2 1077 6.9e-115 PREDICTED: 40S ribosomal protein S6 [Felis catus] 158256465 AK291517.1 811 0 Homo sapiens cDNA FLJ78049 complete cds, highly similar to Homo sapiens ribosomal protein S6 (RPS6), mRNA K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 P62755 1069 2.4e-115 40S ribosomal protein S6 OS=Rattus norvegicus GN=Rps6 PE=1 SV=1 PF02567//PF01092 Phenazine biosynthesis-like protein//Ribosomal protein S6e GO:0042254//GO:0009058//GO:0006412 ribosome biogenesis//biosynthetic process//translation GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG1646 40S ribosomal protein S6 Cluster-10854.0 BP_3 3.00 0.37 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10864.0 BP_3 2.00 1.93 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10870.0 BP_3 2.00 0.51 482 119619953 EAW99547.1 362 3.3e-32 thymosin, beta 10, isoform CRA_a, partial [Homo sapiens]>gi|119619954|gb|EAW99548.1| thymosin, beta 10, isoform CRA_a, partial [Homo sapiens] 79150724 BC107889.1 463 0 Homo sapiens cDNA clone IMAGE:6651898 K13785 TMSB10 thymosin beta 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13785 P63313 219 5.2e-17 Thymosin beta-10 OS=Homo sapiens GN=TMSB10 PE=1 SV=2 PF02205//PF01290 WH2 motif//Thymosin beta-4 family GO:0007015//GO:0042989 actin filament organization//sequestering of actin monomers GO:0003779//GO:0003785 actin binding//actin monomer binding GO:0005737//GO:0005856 cytoplasm//cytoskeleton -- -- Cluster-10877.0 BP_3 4.00 1.29 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10879.0 BP_3 2.00 0.33 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10882.0 BP_3 11.00 0.80 955 385152623 AFI43796.1 511 3.4e-49 ALF1 [Scylla paramamosain] 385152622 JQ069030.1 942 0 Scylla paramamosain ALF1 mRNA, complete cds -- -- -- -- C0KJQ4 462 6.8e-45 Anti-lipopolysaccharide factor OS=Portunus trituberculatus GN=ALF PE=2 SV=2 PF00538 linker histone H1 and H5 family GO:0006334 nucleosome assembly GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-1089.0 BP_3 1.00 0.80 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10892.0 BP_3 1.00 0.51 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10896.0 BP_3 3.00 0.59 536 45361441 NP_989297.1 479 9.9e-46 glutamate-ammonia ligase [Xenopus (Silurana) tropicalis]>gi|847161303|ref|XP_012825210.1| PREDICTED: glutamate-ammonia ligase isoform X1 [Xenopus (Silurana) tropicalis]>gi|39794524|gb|AAH64185.1| hypothetical protein MGC75673 [Xenopus (Silurana) tropicalis] 697079735 XM_009655281.1 422 0 Verticillium dahliae VdLs.17 glutamine synthetase partial mRNA K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 Q12613 642 5.1e-66 Glutamine synthetase OS=Colletotrichum gloeosporioides GN=GLN1 PE=3 SV=1 PF00120 Glutamine synthetase, catalytic domain GO:0006807//GO:0009252//GO:0006542 nitrogen compound metabolic process//peptidoglycan biosynthetic process//glutamine biosynthetic process GO:0005524//GO:0004356 ATP binding//glutamate-ammonia ligase activity -- -- KOG0683 Glutamine synthetase Cluster-10897.0 BP_3 8.00 7.02 340 238683727 ACR54142.1 417 9.7e-39 ribosomal protein rps21 [Palaemon varians] 262401362 FJ774863.1 199 3.35067e-98 Scylla paramamosain ribosomal protein S21 mRNA, partial cds K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q6DDC6 342 2.0e-31 40S ribosomal protein S21 OS=Xenopus tropicalis GN=rps21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-10912.0 BP_3 2.00 0.43 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10915.0 BP_3 5.00 0.74 619 762134385 XP_011450417.1 403 7.4e-37 PREDICTED: histone H2A-like [Crassostrea gigas]>gi|405975240|gb|EKC39821.1| Histone H2A [Crassostrea gigas] 697087517 XM_009658375.1 604 0 Verticillium dahliae VdLs.17 histone H2A mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 Q8X132 488 4.3e-48 Histone H2A OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hh2a PE=3 SV=3 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1756 Histone 2A Cluster-10916.0 BP_3 4.00 0.36 830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825 GPCR proteolysis site, GPS, motif -- -- -- -- GO:0016020 membrane -- -- Cluster-1092.0 BP_3 3.00 2.94 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1092.2 BP_3 19.00 0.91 1295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1092.3 BP_3 4.00 1.89 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1092.4 BP_3 3.00 0.91 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10920.0 BP_3 5.00 0.36 967 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10922.0 BP_3 16.00 0.78 1284 675862458 XP_009016789.1 1209 5.4e-130 hypothetical protein HELRODRAFT_185520 [Helobdella robusta]>gi|555701623|gb|ESO04856.1| hypothetical protein HELRODRAFT_185520 [Helobdella robusta] 697083906 XM_009656719.1 1272 0 Verticillium dahliae VdLs.17 glyceraldehyde-3-phosphate dehydrogenase mRNA K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 P54117 1494 2.0e-164 Glyceraldehyde-3-phosphate dehydrogenase OS=Colletotrichum lindemuthianum GN=GPDA PE=3 SV=1 PF00044//PF02826//PF02800//PF01113 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Dihydrodipicolinate reductase, N-terminus GO:0009085//GO:0055114//GO:0009089 lysine biosynthetic process//oxidation-reduction process//lysine biosynthetic process via diaminopimelate GO:0051287//GO:0016620//GO:0008839 NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//4-hydroxy-tetrahydrodipicolinate reductase -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-10925.0 BP_3 7.00 0.52 942 588481405 AHK23673.1 726 4.0e-74 class II fructose-1,6-bisphosphate aldolase [Chromera velia] 302405876 XM_003000729.1 777 0 Verticillium albo-atrum VaMs.102 fructose-bisphosphate aldolase, mRNA -- -- -- -- P53444 890 1.6e-94 Fructose-bisphosphate aldolase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=fba PE=3 SV=2 PF03585//PF01116 Herpesvirus ICP4-like protein C-terminal region//Fructose-bisphosphate aldolase class-II GO:0045893//GO:0005975 positive regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0008270//GO:0016832 zinc ion binding//aldehyde-lyase activity GO:0042025 host cell nucleus -- -- Cluster-10934.0 BP_3 2.00 0.45 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10935.0 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10948.0 BP_3 1.10 2.23 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10953.0 BP_3 35.00 3.65 754 642936435 XP_008198433.1 188 7.8e-12 PREDICTED: uncharacterized protein LOC103314358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10957.0 BP_3 1.00 0.36 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10961.0 BP_3 4.00 0.78 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10972.0 BP_3 2.00 1.05 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10980.0 BP_3 5.00 0.60 692 805812684 XP_012147726.1 341 1.3e-29 PREDICTED: uncharacterized protein LOC105663446 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10990.0 BP_3 14.70 0.32 2479 270016623 EFA13069.1 2558 3.9e-286 hypothetical protein TcasGA2_TC006868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT41 970 2.2e-103 Transposon Tf2-12 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-12 PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-10994.0 BP_3 2.00 4.04 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10995.0 BP_3 2.43 0.33 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11.0 BP_3 9.00 3.46 416 -- -- -- -- -- 290349777 AB509262.1 128 1.22991e-58 Folsomia candida mRNA for beta-actin, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11006.0 BP_3 4.00 0.62 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11013.0 BP_3 24.80 0.74 1909 91078376 XP_974169.1 2142 5.2e-238 PREDICTED: tyramine beta-hydroxylase [Tribolium castaneum]>gi|270003980|gb|EFA00428.1| hypothetical protein TcasGA2_TC003282 [Tribolium castaneum]>gi|390979538|dbj|BAM21526.1| tyramine beta hydroxylase, partial [Tribolium castaneum] -- -- -- -- -- K00503 DBH dopamine beta-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00503 Q86B61 1286 3.9e-140 Tyramine beta-hydroxylase OS=Drosophila melanogaster GN=Tbh PE=1 SV=1 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0006570//GO:0055114//GO:0006584 tyrosine metabolic process//oxidation-reduction process//catecholamine metabolic process GO:0016715//GO:0004500//GO:0004497//GO:0005507 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//dopamine beta-monooxygenase activity//monooxygenase activity//copper ion binding -- -- KOG3568 Dopamine beta-monooxygenase Cluster-11016.0 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11021.0 BP_3 2.00 1.29 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11026.1 BP_3 17.07 0.72 1432 642917777 XP_008191282.1 906 8.2e-95 PREDICTED: ADP-ribosylation factor-like protein 13B [Tribolium castaneum] -- -- -- -- -- K07962 ARL13B, ARL2L1 ADP-ribosylation factor-like protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K07962 Q3SXY8 427 1.2e-40 ADP-ribosylation factor-like protein 13B OS=Homo sapiens GN=ARL13B PE=1 SV=1 PF08477//PF01926//PF00503//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//G-protein alpha subunit//Ras family//ADP-ribosylation factor family GO:0007264//GO:0007186//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0019001//GO:0004871//GO:0003924//GO:0031683 GTP binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//G-protein beta/gamma-subunit complex binding -- -- KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-11030.0 BP_3 2.00 6.98 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11031.1 BP_3 4.00 0.38 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11033.0 BP_3 3.00 0.33 730 641680650 XP_008189117.1 363 3.8e-32 PREDICTED: probable NADP-dependent mannitol dehydrogenase, partial [Acyrthosiphon pisum] 685856824 XM_009257170.1 259 3.3624e-131 Fusarium pseudograminearum CS3096 MTDH1 (MTDH1), partial mRNA -- -- -- -- Q8NK50 803 1.5e-84 NADP-dependent mannitol dehydrogenase OS=Hypocrea jecorina GN=lxr1 PE=1 SV=1 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-11035.0 BP_3 3.00 0.45 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00569 Zinc finger, ZZ type -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-11039.0 BP_3 2.00 0.69 430 827536713 XP_012544501.1 210 1.2e-14 PREDICTED: venom protease [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-11045.0 BP_3 3.00 0.45 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11050.0 BP_3 19.30 0.43 2477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11062.0 BP_3 7.00 1.58 505 -- -- -- -- -- 573985760 XM_006670738.1 120 4.24417e-54 Cordyceps militaris CM01 glucose repressible protein Grg1 (CCM_05594), partial mRNA -- -- -- -- P22151 228 4.9e-18 Glucose-repressible gene protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=grg-1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0460 Mitochondrial translation elongation factor Tu Cluster-11074.0 BP_3 5.00 0.36 954 662188029 XP_008487669.1 190 5.7e-12 PREDICTED: uncharacterized protein LOC103524433 [Diaphorina citri]>gi|662188031|ref|XP_008487670.1| PREDICTED: uncharacterized protein LOC103524433 [Diaphorina citri]>gi|662219621|ref|XP_008483903.1| PREDICTED: uncharacterized protein LOC103520579 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:1903818//GO:0030431//GO:0032222//GO:0007178//GO:0016310//GO:0009069 positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic//transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-11078.0 BP_3 1.00 0.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11082.0 BP_3 12.20 0.43 1665 91095179 XP_971501.1 786 7.8e-81 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- K16732 PRC1 protein regulator of cytokinesis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16732 Q99K43 517 5.0e-51 Protein regulator of cytokinesis 1 OS=Mus musculus GN=Prc1 PE=2 SV=2 PF03999 Microtubule associated protein (MAP65/ASE1 family) GO:0000226//GO:0000910 microtubule cytoskeleton organization//cytokinesis GO:0008017 microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-11082.1 BP_3 20.81 0.83 1507 91095179 XP_971501.1 905 1.1e-94 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K43 536 2.8e-53 Protein regulator of cytokinesis 1 OS=Mus musculus GN=Prc1 PE=2 SV=2 PF03999 Microtubule associated protein (MAP65/ASE1 family) GO:0000226//GO:0000910 microtubule cytoskeleton organization//cytokinesis GO:0008017 microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-11084.0 BP_3 3.00 8.39 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11090.0 BP_3 2.00 0.57 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11094.0 BP_3 1.00 1.14 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-111.0 BP_3 1.00 0.51 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11100.0 BP_3 9.00 0.60 1020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- O43000 269 1.8e-22 Pantothenate transporter liz1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=liz1 PE=2 SV=2 PF13442 Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0020037//GO:0009055 heme binding//electron carrier activity -- -- -- -- Cluster-11111.0 BP_3 3.00 0.34 720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11117.0 BP_3 14.00 3.33 494 457866969 CCQ18595.1 194 1.0e-12 40S ribosomal protein S25 [Sycon ciliatum] 697083099 XM_009656438.1 462 0 Verticillium dahliae VdLs.17 40S ribosomal protein S25 mRNA K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q7SC06 303 9.6e-27 40S ribosomal protein S25 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-25 PE=3 SV=1 PF08220//PF01047 DeoR-like helix-turn-helix domain//MarR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG1767 40S ribosomal protein S25 Cluster-11118.0 BP_3 3.00 0.35 708 820971343 XP_012358659.1 1083 1.2e-115 PREDICTED: antigen peptide transporter 1 isoform X2 [Nomascus leucogenys] 649103638 KJ892250.1 708 0 Synthetic construct Homo sapiens clone ccsbBroadEn_01644 TAP1 gene, encodes complete protein K05653 ABCB2, TAP1 ATP-binding cassette, subfamily B (MDR/TAP), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05653 Q03518 1099 6.9e-119 Antigen peptide transporter 1 OS=Homo sapiens GN=TAP1 PE=1 SV=2 PF00448//PF00005//PF03193//PF00664//PF13304 SRP54-type protein, GTPase domain//ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system GO:0055085//GO:0006614//GO:0006810 transmembrane transport//SRP-dependent cotranslational protein targeting to membrane//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0058 Peptide exporter, ABC superfamily Cluster-11118.1 BP_3 3.00 0.35 708 189053993 BAG36500.1 992 4.3e-105 unnamed protein product [Homo sapiens] 635372930 NM_001292022.1 708 0 Homo sapiens transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (TAP1), transcript variant 2, mRNA K05653 ABCB2, TAP1 ATP-binding cassette, subfamily B (MDR/TAP), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05653 Q03518 992 1.8e-106 Antigen peptide transporter 1 OS=Homo sapiens GN=TAP1 PE=1 SV=2 PF00005 ABC transporter -- -- GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- KOG0055 Multidrug/pheromone exporter, ABC superfamily Cluster-11120.0 BP_3 10.00 0.44 1380 646722324 KDR23337.1 538 3.7e-52 Cyclin-G2 [Zootermopsis nevadensis] 768416096 XM_011550323.1 35 2.15546e-06 PREDICTED: Plutella xylostella cyclin-G1 (LOC105380726), transcript variant X4, mRNA K10146 CCNG2 cyclin G2 http://www.genome.jp/dbget-bin/www_bget?ko:K10146 O08918 235 2.1e-18 Cyclin-G2 OS=Mus musculus GN=Ccng2 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0653 Cyclin B and related kinase-activating proteins Cluster-11124.0 BP_3 1.00 2.65 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11128.0 BP_3 4.00 0.33 871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11131.0 BP_3 7.00 0.57 884 675372527 KFM65429.1 596 4.4e-59 Cysteine and glycine-rich protein 2, partial [Stegodyphus mimosarum] -- -- -- -- -- K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q3MHY1 402 5.7e-38 Cysteine and glycine-rich protein 1 OS=Bos taurus GN=CSRP1 PE=2 SV=3 PF01641//PF17121//PF00412 SelR domain//Zinc finger, C3HC4 type (RING finger)//LIM domain GO:0055114 oxidation-reduction process GO:0008270//GO:0033743//GO:0005515 zinc ion binding//peptide-methionine (R)-S-oxide reductase activity//protein binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-11138.0 BP_3 2.00 0.52 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11146.0 BP_3 2.00 0.37 549 645011499 XP_003428015.2 204 7.9e-14 PREDICTED: vascular endothelial growth factor C [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11155.0 BP_3 2.00 0.32 594 256261643 ACU65942.1 248 6.7e-19 prophenoloxidase-activating factor [Eriocheir sinensis] 256261642 FJ608827.1 69 1.12888e-25 Eriocheir sinensis prophenoloxidase-activating factor (PPAF) mRNA, complete cds K09640 TMPRSS9 transmembrane protease, serine 9 http://www.genome.jp/dbget-bin/www_bget?ko:K09640 Q402U7 177 4.7e-12 Serine protease 44 OS=Mus musculus GN=Prss44 PE=2 SV=1 PF00089//PF05035 Trypsin//2-keto-3-deoxy-galactonokinase GO:0034194//GO:0006012//GO:0006508 D-galactonate catabolic process//galactose metabolic process//proteolysis GO:0004252//GO:0008671 serine-type endopeptidase activity//2-dehydro-3-deoxygalactonokinase activity -- -- -- -- Cluster-11155.1 BP_3 1.00 1.43 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0003333//GO:0006865 amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-11175.0 BP_3 29.00 0.35 4253 422418 193 1.2e-11 pol protein - fruit fly (Drosophila ananassae) transposon Tom (fragment)>gi|394705|emb|CAA80824.1| pol protein [Drosophila ananassae] -- -- -- -- -- -- -- -- -- P20825 182 8.9e-12 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF07966 A1 Propeptide GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-11178.0 BP_3 5.00 0.43 848 156396829 XP_001637595.1 175 2.8e-10 predicted protein [Nematostella vectensis]>gi|156224708|gb|EDO45532.1| predicted protein [Nematostella vectensis] 697087563 XM_009658398.1 612 0 Verticillium dahliae VdLs.17 RNP domain-containing protein partial mRNA -- -- -- -- Q9P3U1 251 1.8e-20 Uncharacterized RNA-binding protein C328.05 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC328.05 PE=3 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-11184.0 BP_3 3.00 0.70 498 554595613 AGZ01980.1 688 5.4e-70 valosin-containing protein [Penaeus monodon] 554595612 KC570464.1 284 2.84581e-145 Penaeus monodon valosin-containing protein mRNA, complete cds K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 P23787 664 1.3e-68 Transitional endoplasmic reticulum ATPase OS=Xenopus laevis GN=vcp PE=1 SV=3 PF14532//PF01695//PF07728//PF01057//PF05496//PF00158//PF06068//PF00004//PF07724//PF07726//PF02562//PF01637//PF02367//PF04851//PF00910 Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Type III restriction enzyme, res subunit//RNA helicase GO:0006310//GO:0002949//GO:0006281//GO:0019079//GO:0006355 DNA recombination//tRNA threonylcarbamoyladenosine modification//DNA repair//viral genome replication//regulation of transcription, DNA-templated GO:0003677//GO:0003723//GO:0003678//GO:0003724//GO:0009378//GO:0008134//GO:0016787//GO:0005524//GO:0016887 DNA binding//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity//transcription factor binding//hydrolase activity//ATP binding//ATPase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0730 AAA+-type ATPase Cluster-11187.0 BP_3 4.00 0.59 617 91082049 XP_971459.1 530 1.4e-51 PREDICTED: follicle cell protein 3C-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11450 318 2.2e-28 Follicle cell protein 3C-1 OS=Drosophila melanogaster GN=Fcp3C PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-11190.0 BP_3 2.00 0.80 411 646721422 KDR22770.1 283 4.1e-23 UDP-glucuronosyltransferase 2B1, partial [Zootermopsis nevadensis] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P36514 181 1.1e-12 UDP-glucuronosyltransferase 2C1 (Fragment) OS=Oryctolagus cuniculus GN=UGT2C1 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-11193.0 BP_3 6.51 0.60 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11196.0 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11198.0 BP_3 10.00 1.22 687 -- -- -- -- -- 697086427 XM_009657831.1 675 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- P0CX33 149 9.7e-09 40S ribosomal protein S30-A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPS30A PE=1 SV=1 PF04758 Ribosomal protein S30 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0009 Ubiquitin-like/40S ribosomal S30 protein fusion Cluster-11208.1 BP_3 3.00 0.84 464 301500969 YP_003795434.1 195 7.3e-13 ribosomal protein S8 [Alveolata sp. CCMP3155]>gi|300069515|gb|ADJ66622.1| ribosomal protein S8 (chloroplast) [Chromerida sp. RM11] 597569085 KF990036.1 464 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- Q49KW3 408 6.0e-39 30S ribosomal protein S8, chloroplastic OS=Eucalyptus globulus subsp. globulus GN=rps8 PE=3 SV=1 PF00410 Ribosomal protein S8 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0009536//GO:0005840//GO:0030529 plastid//ribosome//intracellular ribonucleoprotein complex -- -- Cluster-11211.0 BP_3 3.00 1.72 373 -- -- -- -- -- 768311757 CP010985.1 367 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- Q9P8W3 165 7.3e-11 Zinc finger transcription factor ace1 OS=Hypocrea jecorina GN=ace1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11213.0 BP_3 1.00 0.32 440 646718614 KDR21026.1 225 2.3e-16 Apolipoprotein D [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03973 Triabin GO:0030682 evasion or tolerance of host defense response -- -- -- -- -- -- Cluster-11214.0 BP_3 5.00 1.85 421 -- -- -- -- -- 768311752 CP010980.1 403 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11215.0 BP_3 4.00 0.79 537 762084667 XP_011424831.1 259 3.2e-20 PREDICTED: histone H1-delta-like [Crassostrea gigas]>gi|762163539|ref|XP_011420060.1| PREDICTED: histone H1-delta-like [Crassostrea gigas]>gi|405971941|gb|EKC36743.1| Histone H5 [Crassostrea gigas]>gi|405977348|gb|EKC41805.1| Histone H5 [Crassostrea gigas] 262401068 FJ774715.1 204 9.11885e-101 Scylla paramamosain histone H1-like protein mRNA, partial cds K11275 H1_5 histone H1/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11275 P06144 222 2.6e-17 Late histone H1 OS=Lytechinus pictus PE=3 SV=1 PF07382//PF00538//PF01873 Histone H1-like nucleoprotein HC2//linker histone H1 and H5 family//Domain found in IF2B/IF5 GO:0006334//GO:0006446//GO:0006413//GO:0030261 nucleosome assembly//regulation of translational initiation//translational initiation//chromosome condensation GO:0003677//GO:0003743 DNA binding//translation initiation factor activity GO:0000786//GO:0005634//GO:0005840 nucleosome//nucleus//ribosome -- -- Cluster-11221.0 BP_3 1.00 0.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08041 PetM family of cytochrome b6f complex subunit 7 -- -- -- -- GO:0009512 cytochrome b6f complex -- -- Cluster-11223.0 BP_3 3.00 0.45 614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08997 Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0015992//GO:0006119//GO:0006118 proton transport//oxidative phosphorylation//obsolete electron transport GO:0008121//GO:0009055 ubiquinol-cytochrome-c reductase activity//electron carrier activity -- -- -- -- Cluster-11229.0 BP_3 5.00 0.66 657 -- -- -- -- -- 768311754 CP010982.1 657 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11232.0 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1124.0 BP_3 4.00 2.17 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11241.0 BP_3 6.00 0.53 838 49659864 AAT68231.1 154 7.5e-08 GekBS029P [Gekko japonicus]>gi|50881972|gb|AAT85561.1| BS010P [Gekko japonicus] 697088024 XM_009658628.1 838 0 Verticillium dahliae VdLs.17 cytochrome c oxidase polypeptide IV mRNA -- -- -- -- P06809 598 1.0e-60 Cytochrome c oxidase subunit 4, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cox-4 PE=3 SV=2 PF01215 Cytochrome c oxidase subunit Vb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005740 respiratory chain complex IV//mitochondrial envelope KOG3352 Cytochrome c oxidase, subunit Vb/COX4 Cluster-11267.0 BP_3 4.00 0.51 671 675375257 KFM68159.1 411 9.6e-38 Angiotensin-converting enzyme, partial [Stegodyphus mimosarum] 884951919 XM_010894495.2 50 4.68425e-15 PREDICTED: Esox lucius angiotensin I converting enzyme (ace), transcript variant X3, mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 388 1.8e-36 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-11278.0 BP_3 5.82 0.41 974 642918710 XP_008191549.1 261 3.4e-20 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11283.0 BP_3 4.00 0.52 664 558230288 XP_006138880.1 157 2.7e-08 PREDICTED: proteasome assembly chaperone 4 [Pelodiscus sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16093 Proteasome assembly chaperone 4 GO:0043248 proteasome assembly -- -- -- -- -- -- Cluster-11295.0 BP_3 4.00 0.36 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05373 L-proline 3-hydroxylase, C-terminal GO:0055114 oxidation-reduction process GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-11299.0 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-113.0 BP_3 2.00 0.85 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-113.1 BP_3 1.00 1.16 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11300.0 BP_3 1.00 0.32 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11300.1 BP_3 1.00 0.52 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11301.0 BP_3 2.00 0.41 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11302.0 BP_3 8.00 0.45 1149 478522514 XP_004435463.1 955 1.4e-100 PREDICTED: rho GDP-dissociation inhibitor 2 [Ceratotherium simum simum] 574957229 NM_001175.5 1146 0 Homo sapiens Rho GDP dissociation inhibitor (GDI) beta (ARHGDIB), mRNA K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q9TU03 943 1.4e-100 Rho GDP-dissociation inhibitor 2 OS=Bos taurus GN=ARHGDIB PE=2 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-11311.1 BP_3 4.00 0.34 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11322.0 BP_3 7.00 0.61 843 545196294 XP_005603298.1 1144 1.2e-122 PREDICTED: proteasome activator complex subunit 2 isoform X2 [Equus caballus] 578825986 XM_006720213.1 802 0 PREDICTED: Homo sapiens proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (PSME2), transcript variant X1, mRNA K06697 PSME2 proteasome activator subunit 2 (PA28 beta) http://www.genome.jp/dbget-bin/www_bget?ko:K06697 Q9UL46 985 1.4e-105 Proteasome activator complex subunit 2 OS=Homo sapiens GN=PSME2 PE=1 SV=4 PF02252//PF02251 Proteasome activator pa28 beta subunit//Proteasome activator pa28 alpha subunit -- -- -- -- GO:0008537 proteasome activator complex KOG4470 Proteasome activator subunit Cluster-11325.0 BP_3 3.21 0.78 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11333.0 BP_3 2.00 0.47 497 795176426 XP_011843698.1 347 1.9e-30 PREDICTED: uncharacterized protein LOC105545383 [Mandrillus leucophaeus] 34528198 AK130958.1 497 0 Homo sapiens cDNA FLJ27448 fis, clone DMC07139 K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P05386 318 1.8e-28 60S acidic ribosomal protein P1 OS=Homo sapiens GN=RPLP1 PE=1 SV=1 PF04625 DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213 structural constituent of chorion GO:0005576//GO:0042600 extracellular region//chorion KOG1762 60s acidic ribosomal protein P1 Cluster-11338.0 BP_3 5.00 0.54 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11339.0 BP_3 2.00 2.50 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1134.0 BP_3 4.00 7.54 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11347.0 BP_3 6.00 0.47 913 262401219 ACY66512.1 277 4.5e-22 hypothetical protein [Scylla paramamosain] 262401218 FJ774791.1 370 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11348.0 BP_3 5.00 0.45 832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11348.1 BP_3 3.00 0.65 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11358.0 BP_3 6.00 0.58 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01442 Apolipoprotein A1/A4/E domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-11366.0 BP_3 6.00 1.38 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11371.0 BP_3 2.00 0.40 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06333//PF05793 Mediator complex subunit 13 C-terminal//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0006367//GO:0032968//GO:0006357 transcription initiation from RNA polymerase II promoter//positive regulation of transcription elongation from RNA polymerase II promoter//regulation of transcription from RNA polymerase II promoter GO:0003677//GO:0001104 DNA binding//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005634 mediator complex//nucleus -- -- Cluster-11383.0 BP_3 2.00 7.85 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11391.0 BP_3 77.00 9.05 702 91091646 XP_970895.1 242 4.0e-18 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000889|gb|EEZ97336.1| hypothetical protein TcasGA2_TC011148 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 170 3.6e-11 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-11391.1 BP_3 90.00 4.56 1242 808872562 KKF21982.1 143 2.1e-06 Protein delta [Larimichthys crocea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11392.0 BP_3 5.00 0.42 862 -- -- -- -- -- 697066206 XM_009649995.1 847 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11395.0 BP_3 4.00 1.79 398 -- -- -- -- -- 768311753 CP010981.1 392 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- O94131 383 4.1e-36 DNA-binding protein creA OS=Gibberella fujikuroi GN=CREA PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11406.0 BP_3 8.95 0.52 1115 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11408.0 BP_3 10.00 0.39 1522 817075170 XP_012259808.1 1882 5.8e-208 PREDICTED: mitochondrial-processing peptidase subunit beta [Athalia rosae] 338224315 HM217796.1 447 0 Scylla paramamosain mitochondrial processing peptidase beta subunit mRNA, partial cds; nuclear gene for mitochondrial product K17732 PMPCB, MAS1 mitochondrial-processing peptidase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17732 Q3SZ71 1709 2.7e-189 Mitochondrial-processing peptidase subunit beta OS=Bos taurus GN=PMPCB PE=2 SV=1 PF00893//PF08367//PF01457 Small Multidrug Resistance protein//Peptidase M16C associated//Leishmanolysin GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004222 metalloendopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0960 Mitochondrial processing peptidase, beta subunit, and related enzymes (insulinase superfamily) Cluster-11411.0 BP_3 12.00 0.46 1536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11416.0 BP_3 38.00 5.10 651 570341954 AHE77375.1 299 9.0e-25 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 232 2.2e-18 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-1142.0 BP_3 2.00 1.02 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11421.0 BP_3 17.00 6.20 423 264667055 ACY71124.1 335 3.9e-29 60S acidic ribosomal protein P2-like protein [Scylla paramamosain] 264667054 FJ790490.1 376 0 Scylla paramamosain 60S acidic ribosomal protein P2-like protein mRNA, complete cds K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P02399 196 2.1e-14 60S acidic ribosomal protein P2 OS=Artemia salina PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-11427.0 BP_3 8.04 0.58 956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11431.2 BP_3 1.00 1.08 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11432.0 BP_3 10.17 0.37 1618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11438.0 BP_3 1.00 0.77 349 593762830 XP_007120058.1 574 6.2e-57 PREDICTED: 60S ribosomal protein L10 [Physeter catodon] 746817425 NM_001256577.2 332 4.01225e-172 Homo sapiens ribosomal protein L10 (RPL10), transcript variant 2, mRNA K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 Q6ZWV3 529 4.2e-53 60S ribosomal protein L10 OS=Mus musculus GN=Rpl10 PE=1 SV=3 PF00252 Ribosomal protein L16p/L10e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-11438.1 BP_3 1.00 0.35 428 821015621 XP_012360595.1 698 3.2e-71 PREDICTED: 60S ribosomal protein L10-like isoform X2 [Nomascus leucogenys] 746817431 NM_001303625.1 428 0 Homo sapiens ribosomal protein L10 (RPL10), transcript variant 5, mRNA K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 Q4R7Y2 652 2.8e-67 60S ribosomal protein L10 OS=Macaca fascicularis GN=RPL10 PE=2 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-11440.0 BP_3 7.00 0.37 1194 321478815 EFX89772.1 534 9.3e-52 hypothetical protein DAPPUDRAFT_303124 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q58D84 431 3.4e-41 Follistatin-related protein 1 OS=Bos taurus GN=FSTL1 PE=2 SV=1 PF13499//PF07648//PF13405//PF13833//PF00036//PF00050//PF12763 EF-hand domain pair//Kazal-type serine protease inhibitor domain//EF-hand domain//EF-hand domain pair//EF hand//Kazal-type serine protease inhibitor domain//Cytoskeletal-regulatory complex EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-11452.1 BP_3 4.62 2.46 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11453.1 BP_3 3.00 0.98 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11456.0 BP_3 3.00 0.71 496 642917965 XP_008198962.1 232 4.0e-17 PREDICTED: sensory neuron membrane protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDD3 159 4.8e-10 Sensory neuron membrane protein 1 OS=Drosophila melanogaster GN=Snmp1 PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-11458.0 BP_3 3.00 0.31 761 758213832 AJO62229.1 278 2.9e-22 olfactory receptor OR10 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- O46077 144 4.1e-08 Odorant receptor 2a OS=Drosophila melanogaster GN=Or2a PE=2 SV=2 PF02949 7tm Odorant receptor GO:0007608//GO:0007187 sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-11468.0 BP_3 2.00 0.43 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11471.0 BP_3 1.00 0.44 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11476.0 BP_3 1.00 0.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11477.0 BP_3 3.00 0.50 580 831774117 XP_012754115.1 548 1.1e-53 hypothetical protein SAMD00019534_060630 [Acytostelium subglobosum LB1]>gi|735854747|dbj|GAM22888.1| hypothetical protein SAMD00019534_060630 [Acytostelium subglobosum LB1] 697084087 XM_009656784.1 577 0 Verticillium dahliae VdLs.17 glycogen phosphorylase partial mRNA K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 P06738 549 3.4e-55 Glycogen phosphorylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GPH1 PE=1 SV=4 PF00343 Carbohydrate phosphorylase GO:0005975 carbohydrate metabolic process GO:0008184 glycogen phosphorylase activity -- -- KOG2099 Glycogen phosphorylase Cluster-11480.0 BP_3 2.00 1.24 366 260823332 XP_002604137.1 371 2.3e-33 hypothetical protein BRAFLDRAFT_113999 [Branchiostoma floridae]>gi|229289462|gb|EEN60148.1| hypothetical protein BRAFLDRAFT_113999 [Branchiostoma floridae] 697090648 XM_009659910.1 363 0 Verticillium dahliae VdLs.17 superoxide dismutase partial mRNA K04564 SOD2 superoxide dismutase, Fe-Mn family http://www.genome.jp/dbget-bin/www_bget?ko:K04564 O13401 356 5.1e-33 Superoxide dismutase [Mn], mitochondrial OS=Candida albicans GN=SOD2 PE=1 SV=1 PF02777//PF00081 Iron/manganese superoxide dismutases, C-terminal domain//Iron/manganese superoxide dismutases, alpha-hairpin domain GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0004784//GO:0046872 superoxide dismutase activity//metal ion binding -- -- KOG0876 Manganese superoxide dismutase Cluster-11483.0 BP_3 6.00 0.83 641 -- -- -- -- -- 697086329 XM_009657782.1 501 0 Verticillium dahliae VdLs.17 ribosomal protein L24E partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11484.0 BP_3 2.00 0.37 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11486.0 BP_3 13.53 0.39 1977 642910986 XP_008193496.1 1097 8.0e-117 PREDICTED: protein scarlet-like [Tribolium castaneum]>gi|744677523|gb|AJD07061.1| brown [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45843 656 4.5e-67 Protein scarlet OS=Drosophila melanogaster GN=st PE=1 SV=3 PF00005//PF01061//PF13304 ABC transporter//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-11490.0 BP_3 2.00 0.36 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- O94131 162 2.4e-10 DNA-binding protein creA OS=Gibberella fujikuroi GN=CREA PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11494.0 BP_3 3.00 0.43 630 -- -- -- -- -- 768311757 CP010985.1 399 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- PF00646//PF00841 F-box domain//Sperm histone P2 GO:0007283 spermatogenesis GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-115.0 BP_3 3.00 0.58 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11504.2 BP_3 3.00 0.44 618 156374958 XP_001629850.1 366 1.5e-32 predicted protein [Nematostella vectensis]>gi|156374960|ref|XP_001629851.1| predicted protein [Nematostella vectensis]>gi|156216859|gb|EDO37787.1| predicted protein [Nematostella vectensis]>gi|156216860|gb|EDO37788.1| predicted protein [Nematostella vectensis] 697068807 XM_009651293.1 595 0 Verticillium dahliae VdLs.17 40S ribosomal protein S20 mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P23403 355 1.1e-32 40S ribosomal protein S20 OS=Xenopus laevis GN=rps20 PE=1 SV=1 -- -- GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0015935 ribosome//small ribosomal subunit KOG0900 40S ribosomal protein S20 Cluster-11506.0 BP_3 3.00 1.03 431 238683705 ACR54131.1 355 1.9e-31 NADH dehydrogenase [Palaemon varians] -- -- -- -- -- K03959 NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03959 Q9CQZ6 155 1.2e-09 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 OS=Mus musculus GN=Ndufb3 PE=1 SV=1 PF08122 NADH-ubiquinone oxidoreductase B12 subunit family GO:0022900 electron transport chain -- -- GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG4631 NADH:ubiquinone oxidoreductase, NDUFB3/B12 subunit Cluster-11509.0 BP_3 6.21 0.86 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1151.0 BP_3 5.60 0.33 1102 270010054 EFA06502.1 869 1.2e-90 hypothetical protein TcasGA2_TC009401 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 324 7.9e-29 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11520.0 BP_3 3.00 0.61 527 221129750 XP_002160238.1 256 7.1e-20 PREDICTED: cytochrome b-c1 complex subunit 7-like [Hydra vulgaris] 697069428 XM_009651603.1 384 0 Verticillium dahliae VdLs.17 cytochrome b-c1 complex subunit 7 partial mRNA K00417 QCR7, UQCRB ubiquinol-cytochrome c reductase subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00417 Q871K1 364 8.7e-34 Cytochrome b-c1 complex subunit 7 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=qcr-7 PE=3 SV=1 PF02271 Ubiquinol-cytochrome C reductase complex 14kD subunit GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750 mitochondrial respiratory chain complex III KOG3440 Ubiquinol cytochrome c reductase, subunit QCR7 Cluster-11522.0 BP_3 1.00 0.48 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11524.0 BP_3 3.78 0.34 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11529.0 BP_3 2.00 0.38 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1153.0 BP_3 14.00 0.85 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11530.0 BP_3 12.51 0.96 921 642919127 XP_974300.2 635 1.4e-63 PREDICTED: glutathione S-transferase 1-like [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VG95 379 2.8e-35 Glutathione S-transferase D5 OS=Drosophila melanogaster GN=GstD5 PE=3 SV=2 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-11534.0 BP_3 2.00 0.62 448 836712689 XP_012790459.1 566 6.8e-56 PREDICTED: 60S ribosomal protein L35a [Sorex araneus] 92446709 BC001783.1 448 0 Homo sapiens mRNA similar to ribosomal protein L35a (cDNA clone IMAGE:3355533) K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 Q5R8K6 566 2.8e-57 60S ribosomal protein L35a OS=Pongo abelii GN=RPL35A PE=3 SV=1 PF01782//PF01247 RimM N-terminal domain//Ribosomal protein L35Ae GO:0042254//GO:0006412//GO:0006364 ribosome biogenesis//translation//rRNA processing GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-11536.0 BP_3 2.00 0.31 598 321475466 EFX86429.1 236 1.7e-17 hypothetical protein DAPPUDRAFT_313132 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q9GNL3 145 2.5e-08 Transmembrane protein fend OS=Drosophila melanogaster GN=fend PE=2 SV=1 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-11539.0 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11548.0 BP_3 3.00 0.93 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1155.0 BP_3 18.00 0.45 2217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11551.0 BP_3 10.00 0.52 1214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11557.0 BP_3 2.00 2.06 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11560.0 BP_3 7.00 0.52 941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-11567.0 BP_3 7.00 4.79 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11568.1 BP_3 4.00 0.54 646 641648497 XP_008182438.1 161 9.0e-09 PREDICTED: uncharacterized protein LOC100574550 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-11571.0 BP_3 2.00 0.31 601 383862935 XP_003706938.1 270 1.9e-21 PREDICTED: ATP synthase subunit delta, mitochondrial [Megachile rotundata] 697074979 XM_009653646.1 576 0 Verticillium dahliae VdLs.17 ATP synthase delta chain mRNA K02134 ATPeF1D, ATP5D, ATP16 F-type H+-transporting ATPase subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K02134 P56525 608 5.1e-62 ATP synthase subunit delta, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=des PE=3 SV=2 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1758 Mitochondrial F1F0-ATP synthase, subunit delta/ATP16 Cluster-11575.0 BP_3 7.00 0.32 1346 826417789 XP_012523702.1 1057 2.4e-112 PREDICTED: microtubule-actin cross-linking factor 1 isoform X31 [Monomorium pharaonis] -- -- -- -- -- K10382 DST dystonin http://www.genome.jp/dbget-bin/www_bget?ko:K10382 D3ZHV2 817 6.6e-86 Microtubule-actin cross-linking factor 1 OS=Rattus norvegicus GN=Macf1 PE=1 SV=1 PF13499//PF13833//PF13405//PF00036//PF02187//PF13202 EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Growth-Arrest-Specific Protein 2 Domain//EF hand GO:0007050 cell cycle arrest GO:0005509 calcium ion binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-11582.0 BP_3 2.00 0.50 486 -- -- -- -- -- 302406916 XM_003001248.1 300 3.53591e-154 Verticillium albo-atrum VaMs.102 mitochondrial F1F0 ATP synthase subunit F Atp17, mRNA -- -- -- -- Q06405 299 2.8e-26 ATP synthase subunit f, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATP17 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11583.0 BP_3 2.00 0.33 586 597783634 XP_007255336.1 159 1.4e-08 PREDICTED: SH2 domain-containing protein 4A-like isoform X1 [Astyanax mexicanus]>gi|597783636|ref|XP_007255337.1| PREDICTED: SH2 domain-containing protein 4A-like isoform X2 [Astyanax mexicanus]>gi|597783638|ref|XP_007255338.1| PREDICTED: SH2 domain-containing protein 4A-like isoform X3 [Astyanax mexicanus] -- -- -- -- -- -- -- -- -- Q08CX2 142 5.3e-08 SH2 domain-containing protein 4A OS=Xenopus tropicalis GN=sh2d4a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11584.0 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11588.0 BP_3 14.00 1.73 681 256002943 ACU52718.1 889 3.6e-93 ribosomal protein L10a [Fenneropenaeus merguiensis] 256002942 FJ623402.1 309 5.013e-159 Fenneropenaeus merguiensis ribosomal protein L10a mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 780 6.5e-82 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG1570 60S ribosomal protein L10A Cluster-11591.0 BP_3 3.00 0.33 732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11592.0 BP_3 4.13 1.26 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11593.0 BP_3 2.00 0.73 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-116.0 BP_3 1.00 1.01 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11601.0 BP_3 4.00 0.49 688 8439415 CAB94199.1 1194 1.6e-128 tryptophanyl-tRNA synthetase [Homo sapiens] 261861535 AB529126.1 688 0 Synthetic construct DNA, clone: pF1KB4987, Homo sapiens WARS gene for tryptophanyl-tRNA synthetase, without stop codon, in Flexi system K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 P23381 1194 6.5e-130 Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens GN=WARS PE=1 SV=2 PF00579 tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding -- -- KOG2145 Cytoplasmic tryptophanyl-tRNA synthetase Cluster-11615.0 BP_3 1.00 0.90 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane -- -- Cluster-11616.0 BP_3 5.00 0.56 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11622.0 BP_3 2.00 0.41 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11630.0 BP_3 4.00 0.50 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11635.0 BP_3 1.00 0.47 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11637.0 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01655 Ribosomal protein L32 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-11640.0 BP_3 9.24 0.32 1668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11651.1 BP_3 7.00 0.41 1106 -- -- -- -- -- 488892481 JX310001.1 911 0 Prunus persica carotenoid cleavage dioxygenase 4 (ccd4) gene, ccd4-Y2 allele, complete sequence; microsatellite Ppccd4-ssr sequence; and retrotransposon Gypsy and Copia like, complete sequence -- -- -- -- -- -- -- -- PF06156//PF04977//PF04111//PF00170//PF06005//PF10473//PF07544//PF15898 Protein of unknown function (DUF972)//Septum formation initiator//Autophagy protein Apg6//bZIP transcription factor//Protein of unknown function (DUF904)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//RNA polymerase II transcription mediator complex subunit 9//cGMP-dependent protein kinase interacting domain GO:0006914//GO:0007049//GO:0006357//GO:0006355//GO:0006260//GO:0043093//GO:0000917 autophagy//cell cycle//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//DNA replication//FtsZ-dependent cytokinesis//barrier septum assembly GO:0045502//GO:0008134//GO:0003700//GO:0043565//GO:0019901//GO:0001104//GO:0042803 dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein kinase binding//RNA polymerase II transcription cofactor activity//protein homodimerization activity GO:0005737//GO:0005667//GO:0016592//GO:0030286 cytoplasm//transcription factor complex//mediator complex//dynein complex -- -- Cluster-11653.1 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11655.0 BP_3 5.00 0.31 1060 -- -- -- -- -- 768311758 CP010986.1 1039 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- Q10347 287 1.5e-24 Uncharacterized protein C1F12.05 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC1F12.05 PE=4 SV=1 PF00857//PF03741 Isochorismatase family//Integral membrane protein TerC family GO:0008152 metabolic process GO:0003824 catalytic activity GO:0016021 integral component of membrane -- -- Cluster-11655.1 BP_3 5.00 0.52 751 -- -- -- -- -- 768311758 CP010986.1 729 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11656.0 BP_3 2.00 0.60 452 -- -- -- -- -- 116309050 CR855064.1 452 0 Oryza sativa genomic DNA, chromosome 4, BAC clone: H0107B07, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11658.1 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11659.0 BP_3 20.00 2.12 747 -- -- -- -- -- 697072011 XM_009652608.1 698 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- PF04741 InvH outer membrane lipoprotein GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-11661.0 BP_3 29.87 0.82 2057 478250463 ENN70958.1 2171 2.4e-241 hypothetical protein YQE_12359, partial [Dendroctonus ponderosae] -- -- -- -- -- K05313 GRIN glutamate receptor, ionotropic, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05313 P42260 532 1.1e-52 Glutamate receptor ionotropic, kainate 2 OS=Rattus norvegicus GN=Grik2 PE=1 SV=2 PF03100//PF10613//PF00060 CcmE//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006811//GO:0017004//GO:0017003//GO:0007268//GO:0007165 ion transport//cytochrome complex assembly//protein-heme linkage//synaptic transmission//signal transduction GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020//GO:0005886 membrane//plasma membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-11668.0 BP_3 6.00 0.32 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane -- -- Cluster-11668.1 BP_3 4.00 0.39 788 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11687.0 BP_3 17.00 1.05 1075 470364926 XP_004365977.1 410 2.0e-37 60S ribosomal protein L6 [Capsaspora owczarzaki ATCC 30864]>gi|765549051|gb|KJE89672.1| 60S ribosomal protein L6 [Capsaspora owczarzaki ATCC 30864] 697067842 XM_009650811.1 609 0 Verticillium dahliae VdLs.17 60S ribosomal protein L6-3 partial mRNA K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 P05739 467 2.0e-45 60S ribosomal protein L6-B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL6B PE=1 SV=4 PF01159 Ribosomal protein L6e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1694 60s ribosomal protein L6 Cluster-11691.0 BP_3 4.00 0.60 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11692.0 BP_3 7.00 0.34 1286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-117.0 BP_3 11.00 2.27 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1170.0 BP_3 2.00 0.31 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11702.0 BP_3 17.15 0.49 1994 642916232 XP_008190940.1 219 5.2e-15 PREDICTED: two pore potassium channel protein sup-9 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11715.0 BP_3 10.00 1.17 703 161671282 ABX75493.1 718 2.5e-73 40S ribosomal protein S5 [Lycosa singoriensis] 697083096 XM_009656437.1 697 0 Verticillium dahliae VdLs.17 40S ribosomal protein S5-B mRNA K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 Q7RVI1 884 5.8e-94 40S ribosomal protein S5 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-5 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-11719.0 BP_3 3.00 0.54 559 694533470 XP_009494755.1 347 2.1e-30 hypothetical protein H696_02569 [Fonticula alba]>gi|627948331|gb|KCV70239.1| hypothetical protein H696_02569 [Fonticula alba] 697084446 XM_009656912.1 559 0 Verticillium dahliae VdLs.17 disulfide-isomerase mRNA K08056 PDIA3, GRP58 protein disulfide isomerase family A, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08056 P55059 625 5.0e-64 Protein disulfide-isomerase OS=Humicola insolens PE=1 SV=1 PF08534//PF00085//PF01216//PF00578 Redoxin//Thioredoxin//Calsequestrin//AhpC/TSA family GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0005509//GO:0016209//GO:0016491 calcium ion binding//antioxidant activity//oxidoreductase activity -- -- KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-11722.0 BP_3 1.00 0.45 398 646701959 KDR11426.1 300 4.2e-25 Protein neuralized [Zootermopsis nevadensis] 333103093 JF715398.1 112 9.19008e-50 Scylla paramamosain clone SP14 microsatellite sequence K01931 NEUR protein neuralized http://www.genome.jp/dbget-bin/www_bget?ko:K01931 P29503 287 5.6e-25 Protein neuralized OS=Drosophila melanogaster GN=neur PE=1 SV=2 PF13639//PF14634//PF00097 Ring finger domain//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG4172 Predicted E3 ubiquitin ligase Cluster-11726.0 BP_3 2.00 0.46 499 861633328 KMQ90923.1 351 6.4e-31 transposable element tc3 transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11729.0 BP_3 50.67 0.76 3504 642935498 XP_008198034.1 4844 0.0e+00 PREDICTED: rap guanine nucleotide exchange factor 4 isoform X1 [Tribolium castaneum] 676496084 XM_009068851.1 107 5.25027e-46 Lottia gigantea hypothetical protein partial mRNA K04351 RAPGEF4, EPAC2 Rap guanine nucleotide exchange factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04351 Q8WZA2 2594 1.5e-291 Rap guanine nucleotide exchange factor 4 OS=Homo sapiens GN=RAPGEF4 PE=1 SV=1 PF00610//PF00617 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//RasGEF domain GO:0007264//GO:0035556//GO:0043087 small GTPase mediated signal transduction//intracellular signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG2378 cAMP-regulated guanine nucleotide exchange factor Cluster-11735.0 BP_3 2.00 0.38 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11736.0 BP_3 3.00 0.58 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11737.0 BP_3 3.00 2.59 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11751.0 BP_3 2.00 0.41 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11757.0 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11767.0 BP_3 2.00 0.78 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07989//PF05924//PF09302//PF07716//PF06005//PF01576//PF13851 Centrosomin N-terminal motif 1//SAMP Motif//XLF-Cernunnos, XRcc4-like factor, NHEJ component//Basic region leucine zipper//Protein of unknown function (DUF904)//Myosin tail//Growth-arrest specific micro-tubule binding GO:0043093//GO:0000917//GO:0048870//GO:0016055//GO:0006302//GO:0006355 FtsZ-dependent cytokinesis//barrier septum assembly//cell motility//Wnt signaling pathway//double-strand break repair//regulation of transcription, DNA-templated GO:0003774//GO:0003700//GO:0008013//GO:0043565 motor activity//transcription factor activity, sequence-specific DNA binding//beta-catenin binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005737//GO:0016342//GO:0005815//GO:0016459//GO:0031514 transcription factor complex//nucleus//cytoplasm//catenin complex//microtubule organizing center//myosin complex//motile cilium -- -- Cluster-11772.0 BP_3 1.00 1.69 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01975//PF12300 Survival protein SurE//Protein of unknown function (DUF3628) -- -- GO:0016787//GO:0016817 hydrolase activity//hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-11776.0 BP_3 8.00 0.78 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11779.0 BP_3 5.00 0.41 878 -- -- -- -- -- 392303592 JX102625.1 297 3.06408e-152 Scylla paramamosain microsatellite Spm54 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1179.0 BP_3 4.00 0.93 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11797.0 BP_3 4.00 0.34 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-118.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1180.0 BP_3 3.78 0.52 639 546675389 ERL86594.1 336 4.5e-29 hypothetical protein D910_04001 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- W4VS53 160 4.8e-10 CRISP/Allergen/PR-1 OS=Trittame loki PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3017 Defense-related protein containing SCP domain Cluster-11802.0 BP_3 3.00 0.85 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11806.0 BP_3 11.00 0.84 926 803007392 XP_011966855.1 570 4.8e-56 PREDICTED: 40S ribosomal protein S7 isoform X1, partial [Ovis aries] 768311754 CP010982.1 648 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 O43105 833 6.3e-88 40S ribosomal protein S7 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=crp-15 PE=3 SV=2 PF01251 Ribosomal protein S7e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3320 40S ribosomal protein S7 Cluster-11808.0 BP_3 9.20 6.38 357 91078376 XP_974169.1 252 1.4e-19 PREDICTED: tyramine beta-hydroxylase [Tribolium castaneum]>gi|270003980|gb|EFA00428.1| hypothetical protein TcasGA2_TC003282 [Tribolium castaneum]>gi|390979538|dbj|BAM21526.1| tyramine beta hydroxylase, partial [Tribolium castaneum] -- -- -- -- -- K00503 DBH dopamine beta-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00503 -- -- -- -- -- -- GO:0006584//GO:0006570//GO:0055114 catecholamine metabolic process//tyrosine metabolic process//oxidation-reduction process GO:0005507//GO:0004500 copper ion binding//dopamine beta-monooxygenase activity -- -- -- -- Cluster-11810.0 BP_3 9.00 0.40 1363 546679567 ERL90015.1 1632 5.1e-179 hypothetical protein D910_07373 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11813.0 BP_3 17.00 0.51 1891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11817.0 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11825.0 BP_3 4.00 0.43 742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11826.0 BP_3 2.00 0.37 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11829.0 BP_3 8.00 0.50 1059 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11833.0 BP_3 5.88 0.49 869 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1185.0 BP_3 7.00 0.53 927 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11864.0 BP_3 12.00 0.60 1252 499002174 XP_004534773.1 523 1.8e-50 PREDICTED: cofilin/actin-depolymerizing factor homolog [Ceratitis capitata] 338224338 HM217810.1 365 0 Scylla paramamosain actin-depolymerizing factor 4-like mRNA, partial sequence K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 517 3.8e-51 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1735 Actin depolymerizing factor Cluster-11867.0 BP_3 24.00 0.78 1774 91089113 XP_972237.1 966 1.1e-101 PREDICTED: pickpocket protein 28 [Tribolium castaneum]>gi|270012423|gb|EFA08871.1| hypothetical protein TcasGA2_TC006572 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86LG1 457 4.8e-44 Pickpocket protein 28 OS=Drosophila melanogaster GN=ppk28 PE=1 SV=2 PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-11872.0 BP_3 4.00 0.49 689 270017036 EFA13482.1 382 2.3e-34 hypothetical protein TcasGA2_TC002033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX7 147 1.7e-08 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11877.0 BP_3 2.00 0.44 509 -- -- -- -- -- 462339191 APGK01036907.1 230 3.03945e-115 Dendroctonus ponderosae Seq01036917, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11879.0 BP_3 36.00 1.12 1836 241708208 XP_002413321.1 869 2.0e-90 LIM domain-binding protein, putative [Ixodes scapularis]>gi|215507135|gb|EEC16629.1| LIM domain-binding protein, putative, partial [Ixodes scapularis] 338224401 HM217844.1 467 0 Scylla paramamosain LIM domain-binding protein-like mRNA, partial sequence -- -- -- -- A1ZA47 812 3.4e-85 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00412//PF00020 LIM domain//TNFR/NGFR cysteine-rich region -- -- GO:0016740//GO:0008270//GO:0005515//GO:0046872 transferase activity//zinc ion binding//protein binding//metal ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-11880.0 BP_3 6.00 0.43 962 700894661 AIU99749.1 376 1.6e-33 mitochondrial cytochrome c oxidase subunit VIb [Litopenaeus vannamei] 392303568 JX102601.1 436 0 Scylla paramamosain microsatellite Spm30 sequence K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 O94581 258 3.1e-21 Cytochrome c oxidase subunit 6B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cox12 PE=3 SV=2 PF02297//PF02072 Cytochrome oxidase c subunit VIb//Prepro-orexin GO:0007631//GO:0007218//GO:0006123//GO:0015992 feeding behavior//neuropeptide signaling pathway//mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005739//GO:0045277 mitochondrion//respiratory chain complex IV KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-11882.1 BP_3 79.00 2.34 1916 828216069 XP_012560185.1 736 5.6e-75 PREDICTED: uncharacterized protein LOC105846225 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-11884.0 BP_3 7.55 3.26 402 478260022 ENN79811.1 169 6.6e-10 hypothetical protein YQE_03752, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11888.0 BP_3 8.00 1.01 675 3287776 P81388.1 274 7.4e-22 RecName: Full=Cuticle protein AMP4; AltName: Full=HA-AMP4 [Homarus americanus] -- -- -- -- -- -- -- -- -- P81576 302 1.7e-26 Cuticle protein AM1159 OS=Cancer pagurus PE=1 SV=1 PF02214//PF00379 BTB/POZ domain//Insect cuticle protein GO:0051260 protein homooligomerization GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-11890.0 BP_3 2.00 1.37 358 119579909 EAW59505.1 511 1.3e-49 hCG2043213, partial [Homo sapiens] 21410210 BC030984.1 340 1.4737e-176 Homo sapiens cDNA clone MGC:32654 IMAGE:4701898, complete cds -- -- -- -- P06316 406 7.9e-39 Ig lambda chain V-I region BL2 OS=Homo sapiens PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11892.0 BP_3 11.00 0.54 1273 270161184 ACZ63472.1 405 9.0e-37 i-type lysozyme-like protein 2 [Penaeus monodon] -- -- -- -- -- -- -- -- -- Q6L6Q6 191 2.4e-13 Lysozyme OS=Crassostrea gigas GN=lysoz PE=2 SV=1 PF00404//PF07645//PF05497 Dockerin type I repeat//Calcium-binding EGF domain//Destabilase GO:0005975 carbohydrate metabolic process GO:0003796//GO:0005509//GO:0004553 lysozyme activity//calcium ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-11894.0 BP_3 6.00 0.83 639 150010589 NP_003632.3 651 1.3e-65 interferon-induced transmembrane protein 1 [Homo sapiens]>gi|311771581|ref|NP_001185687.1| interferon-induced transmembrane protein 1 [Pan troglodytes]>gi|397468804|ref|XP_003806061.1| PREDICTED: interferon-induced transmembrane protein 1 [Pan paniscus]>gi|694942607|ref|XP_009457888.1| PREDICTED: interferon-induced transmembrane protein 1 isoform X1 [Pan troglodytes]>gi|1177476|emb|CAA59337.1| interferon-inducible protein [Homo sapiens]>gi|12654159|gb|AAH00897.1| Interferon induced transmembrane protein 1 (9-27) [Homo sapiens]>gi|30583185|gb|AAP35837.1| interferon induced transmembrane protein 1 (9-27) [Homo sapiens]>gi|60654831|gb|AAX31980.1| interferon induced transmembrane protein 1 [synthetic construct]>gi|119581622|gb|EAW61218.1| interferon induced transmembrane protein 1 (9-27), isoform CRA_a [Homo sapiens]>gi|119581623|gb|EAW61219.1| interferon induced transmembrane protein 1 (9-27), isoform CRA_a [Homo sapiens]>gi|123980382|gb|ABM82020.1| interferon induced transmembrane protein 1 (9-27) [synthetic construct]>gi|123995201|gb|ABM85202.1| interferon induced transmembrane protein 1 (9-27) [synthetic construct]>gi|158254392|dbj|BAF83169.1| unnamed protein product [Homo sapiens]>gi|307684472|dbj|BAJ20276.1| interferon induced transmembrane protein 1 [synthetic construct]>gi|649104611|gb|AIC50137.1| IFITM1, partial [synthetic construct] 150010588 NM_003641.3 639 0 Homo sapiens interferon induced transmembrane protein 1 (IFITM1), mRNA K06566 IFITM interferon induced transmembrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K06566 P13164 646 2.1e-66 Interferon-induced transmembrane protein 1 OS=Homo sapiens GN=IFITM1 PE=1 SV=3 PF04505 Interferon-induced transmembrane protein GO:0035455//GO:0030336//GO:0051607//GO:0008285//GO:0007165//GO:0045669//GO:0045071//GO:0035456//GO:0009607//GO:0050776//GO:0046597//GO:0034341//GO:0060337 response to interferon-alpha//negative regulation of cell migration//defense response to virus//negative regulation of cell proliferation//signal transduction//positive regulation of osteoblast differentiation//negative regulation of viral genome replication//response to interferon-beta//response to biotic stimulus//regulation of immune response//negative regulation of viral entry into host cell//response to interferon-gamma//type I interferon signaling pathway GO:0005057//GO:0005515 receptor signaling protein activity//protein binding GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-11898.0 BP_3 6.00 0.72 691 328900032 AEB54654.1 268 3.8e-21 ATPase inhibitory factor 1 [Procambarus clarkii] -- -- -- -- -- -- -- -- -- A8XZB0 157 1.2e-09 ATPase inhibitor mai-2, mitochondrial OS=Caenorhabditis briggsae GN=mai-2 PE=3 SV=1 PF04568 Mitochondrial ATPase inhibitor, IATP GO:0032780 negative regulation of ATPase activity GO:0042030 ATPase inhibitor activity GO:0005739 mitochondrion -- -- Cluster-119.0 BP_3 2.00 1.37 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11901.0 BP_3 5.92 1.08 556 642930372 XP_008196370.1 365 1.7e-32 PREDICTED: mothers against decapentaplegic homolog 3 [Tribolium castaneum] -- -- -- -- -- K04500 SMAD2_3 mothers against decapentaplegic homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K04500 O70436 263 4.7e-22 Mothers against decapentaplegic homolog 2 OS=Rattus norvegicus GN=Smad2 PE=1 SV=1 PF03165 MH1 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-11908.0 BP_3 5.00 0.45 825 270017202 EFA13648.1 542 7.6e-53 hypothetical protein TcasGA2_TC015886 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11910.0 BP_3 10.00 0.45 1369 873224191 CEM26909.1 761 5.1e-78 unnamed protein product [Vitrella brassicaformis CCMP3155] 302414091 XM_003004832.1 1081 0 Verticillium albo-atrum VaMs.102 conserved hypothetical protein, mRNA -- -- -- -- Q9XIG1 703 1.1e-72 Sterol 3-beta-glucosyltransferase UGT80B1 OS=Arabidopsis thaliana GN=UGT80B1 PE=2 SV=1 PF03033 Glycosyltransferase family 28 N-terminal domain GO:0005975//GO:0030259 carbohydrate metabolic process//lipid glycosylation GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-11910.1 BP_3 11.00 0.47 1427 873228375 CEM15978.1 974 1.1e-102 unnamed protein product [Vitrella brassicaformis CCMP3155] 768311752 CP010980.1 1192 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q07103 1674 2.9e-185 Formate dehydrogenase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=fdh PE=2 SV=1 PF03446//PF02826//PF00389 NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0055114//GO:0019521//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//metabolic process//pentose-phosphate shunt GO:0051287//GO:0016616//GO:0004616 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-11921.0 BP_3 10.00 1.18 701 795044513 XP_011867945.1 273 1.0e-21 PREDICTED: uncharacterized protein LOC105562053 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11923.0 BP_3 3.00 0.52 569 426387489 XP_004060199.1 318 4.9e-27 PREDICTED: elongation factor 1-delta-like [Gorilla gorilla gorilla] 697067858 XM_009650819.1 410 0 Verticillium dahliae VdLs.17 elongation factor 1-beta partial mRNA K15410 EEF1D elongation factor 1-delta http://www.genome.jp/dbget-bin/www_bget?ko:K15410 O74173 338 9.7e-31 Elongation factor 1-beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tef5 PE=2 SV=1 PF00736 EF-1 guanine nucleotide exchange domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840//GO:0005853 ribosome//eukaryotic translation elongation factor 1 complex KOG1668 Elongation factor 1 beta/delta chain Cluster-11924.0 BP_3 4.00 0.88 510 157115780 XP_001652693.1 168 1.1e-09 AAEL007344-PA [Aedes aegypti]>gi|108876761|gb|EAT40986.1| AAEL007344-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11927.0 BP_3 1.00 0.71 355 -- -- -- -- -- 768311759 CP010987.1 355 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11932.0 BP_3 5.78 8.96 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11943.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1195.0 BP_3 2.00 0.57 461 270005976 EFA02424.1 516 4.4e-50 hypothetical protein TcasGA2_TC008109 [Tribolium castaneum] -- -- -- -- -- K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q45VK7 242 1.1e-19 Cytoplasmic dynein 2 heavy chain 1 OS=Mus musculus GN=Dync2h1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3595 Dyneins, heavy chain Cluster-11953.0 BP_3 12.89 0.60 1334 571330962 AHF27413.1 737 3.0e-75 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- Q291H8 271 1.3e-22 Facilitated trehalose transporter Tret1 OS=Drosophila pseudoobscura pseudoobscura GN=Tret1 PE=3 SV=3 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-11956.0 BP_3 3.00 0.32 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03568 Peptidase family C50 GO:0006508 proteolysis GO:0008233 peptidase activity GO:0005634 nucleus -- -- Cluster-11959.0 BP_3 2.00 0.71 426 795290659 XP_011821377.1 718 1.5e-73 PREDICTED: oxysterols receptor LXR-beta isoform X2 [Mandrillus leucophaeus] 649121746 KJ897727.1 426 0 Synthetic construct Homo sapiens clone ccsbBroadEn_07121 NR1H2 gene, encodes complete protein K08535 NR1H2, LXRB liver X receptor beta http://www.genome.jp/dbget-bin/www_bget?ko:K08535 P55055 718 6.3e-75 Oxysterols receptor LXR-beta OS=Homo sapiens GN=NR1H2 PE=1 SV=2 PF00104 Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-11968.1 BP_3 5.00 0.32 1056 678329097 CDW79830.1 144 1.4e-06 peptidyl-prolyl cis-trans isomerase [Stylonychia lemnae] -- -- -- -- -- -- -- -- -- Q9C566 130 2.4e-06 Peptidyl-prolyl cis-trans isomerase CYP40 OS=Arabidopsis thaliana GN=CYP40 PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- -- -- Cluster-11972.0 BP_3 3.00 0.60 531 -- -- -- -- -- 462379193 APGK01022736.1 58 1.30521e-19 Dendroctonus ponderosae Seq01022746, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11980.0 BP_3 1.00 0.37 421 321449650 EFX61998.1 342 6.0e-30 hypothetical protein DAPPUDRAFT_120652, partial [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02822 Antistasin family -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-11983.1 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11986.0 BP_3 2.00 0.31 603 270010574 EFA07022.1 287 2.1e-23 hypothetical protein TcasGA2_TC009993 [Tribolium castaneum] -- -- -- -- -- K13254 SPAST spastin http://www.genome.jp/dbget-bin/www_bget?ko:K13254 Q05AS3 230 3.4e-18 Spastin OS=Xenopus tropicalis GN=spast PE=2 SV=1 PF00004 ATPase family associated with various cellular activities (AAA) -- -- GO:0005524 ATP binding -- -- KOG0740 AAA+-type ATPase Cluster-11996.2 BP_3 43.00 0.54 4138 -- -- -- -- -- 372461088 JF715240.1 53 6.47937e-16 Fenneropenaeus indicus clone Lvan052 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11997.0 BP_3 1.00 0.40 411 617431084 XP_007561838.1 135 5.9e-06 PREDICTED: serine protease 27-like [Poecilia formosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12.0 BP_3 15.00 2.05 644 170034112 XP_001844919.1 233 4.0e-17 conserved hypothetical protein [Culex quinquefasciatus]>gi|167875327|gb|EDS38710.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- P11734 212 4.5e-16 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-120.0 BP_3 2.00 7.62 272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12003.0 BP_3 4.00 0.54 648 608073328 AHW49376.1 1044 3.7e-111 interferon regulatory factor 1 isoform +I9 [Homo sapiens] 608073327 KJ200632.1 648 0 Homo sapiens interferon regulatory factor 1 isoform +I9 (IRF-1) mRNA, complete cds, alternatively spliced K09444 IRF1 interferon regulatory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09444 P10914 1044 1.5e-112 Interferon regulatory factor 1 OS=Homo sapiens GN=IRF1 PE=1 SV=2 PF00605 Interferon regulatory factor transcription factor -- -- GO:0000975 regulatory region DNA binding -- -- -- -- Cluster-12007.0 BP_3 5.00 0.65 663 675388247 KFM81144.1 806 1.5e-83 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase, partial [Stegodyphus mimosarum] 768937757 XM_003970462.2 160 3.28464e-76 PREDICTED: Takifugu rubripes O-linked N-acetylglucosamine (GlcNAc) transferase (ogt), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 763 5.9e-80 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13414//PF13176//PF13371//PF00515//PF13374//PF13174//PF10590//PF07721//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0055114 oxidation-reduction process GO:0042802//GO:0005515//GO:0016638 identical protein binding//protein binding//oxidoreductase activity, acting on the CH-NH2 group of donors -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-12008.0 BP_3 5.00 1.61 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12009.0 BP_3 10.00 0.74 939 762126085 XP_011446088.1 782 1.3e-80 PREDICTED: 40S ribosomal protein S6-like [Crassostrea gigas] 589102872 XM_006963397.1 544 0 Trichoderma reesei QM6a 40s ribosomal protein S6 (TRIREDRAFT_120781), mRNA K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 Q9C0Z7 879 3.0e-93 40S ribosomal protein S6-B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rps602 PE=1 SV=1 PF03811//PF01092 InsA N-terminal domain//Ribosomal protein S6e GO:0006412//GO:0042254//GO:0006313 translation//ribosome biogenesis//transposition, DNA-mediated GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1646 40S ribosomal protein S6 Cluster-12013.0 BP_3 3.00 0.33 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12015.0 BP_3 3.00 0.38 676 237835649 XP_002367122.1 338 2.8e-29 heat shock protein 60 [Toxoplasma gondii ME49]>gi|523577017|gb|EPR63675.1| heat shock protein HSP60 [Toxoplasma gondii GT1]>gi|527308303|gb|EPT24942.1| heat shock protein HSP60 [Toxoplasma gondii ME49]>gi|557738413|gb|ESS34352.1| heat shock protein HSP60 [Toxoplasma gondii VEG]>gi|672275017|gb|KFG46749.1| heat shock protein HSP60 [Toxoplasma gondii GAB2-2007-GAL-DOM2]>gi|672276817|gb|KFG48175.1| heat shock protein HSP60 [Toxoplasma gondii p89]>gi|672285238|gb|KFG54020.1| heat shock protein HSP60 [Toxoplasma gondii FOU]>gi|672301162|gb|KFG64488.1| heat shock protein HSP60 [Toxoplasma gondii RUB]>gi|672573636|gb|KFH12306.1| heat shock protein HSP60 [Toxoplasma gondii VAND]>gi|672578416|gb|KFH16085.1| heat shock protein HSP60 [Toxoplasma gondii MAS]>gi|820702671|tpe|CEL78406.1| TPA: heat shock protein 60 [Toxoplasma gondii VEG] 768311756 CP010984.1 673 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 Q5B041 530 6.3e-53 Heat shock protein 60 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=hsp60 PE=1 SV=1 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-12017.1 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12018.0 BP_3 6.00 0.41 1005 488888854 AGL08671.1 1363 5.8e-148 laminin receptor 1 [Ctenopharyngodon idella] 747165387 NM_002295.5 765 0 Homo sapiens ribosomal protein SA (RPSA), transcript variant 1, mRNA K02998 RP-SAe, RPSA small subunit ribosomal protein SAe http://www.genome.jp/dbget-bin/www_bget?ko:K02998 Q803F6 1356 1.6e-148 40S ribosomal protein SA OS=Danio rerio GN=rpsa PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-12022.0 BP_3 17.79 0.35 2769 642913113 XP_008201397.1 1541 3.7e-168 PREDICTED: centrosomal protein of 290 kDa-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P85001 385 1.7e-35 Centrosomal protein of 290 kDa OS=Danio rerio GN=cep290 PE=2 SV=1 PF15898//PF17060//PF00038//PF05557//PF04618//PF04728//PF10473//PF04508//PF04632//PF06156//PF04111//PF05531//PF11382 cGMP-dependent protein kinase interacting domain//Monopolar spindle protein 2//Intermediate filament protein//Mitotic checkpoint protein//HD-ZIP protein N terminus//Lipoprotein leucine-zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Viral A-type inclusion protein repeat//Fusaric acid resistance protein family//Protein of unknown function (DUF972)//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein//Copper transport outer membrane protein, MctB GO:0030474//GO:0016032//GO:0007094//GO:0071988//GO:0006810//GO:0006914//GO:0006260 spindle pole body duplication//viral process//mitotic spindle assembly checkpoint//protein localization to spindle pole body//transport//autophagy//DNA replication GO:0042803//GO:0045502//GO:0008134//GO:0005198//GO:0019901 protein homodimerization activity//dynein binding//transcription factor binding//structural molecule activity//protein kinase binding GO:0005667//GO:0019867//GO:0030286//GO:0005886//GO:0005634//GO:0005882//GO:0019028 transcription factor complex//outer membrane//dynein complex//plasma membrane//nucleus//intermediate filament//viral capsid -- -- Cluster-12024.0 BP_3 2.00 0.37 553 646695965 KDR08559.1 854 3.4e-89 hypothetical protein L798_01354, partial [Zootermopsis nevadensis] 308222731 EF036538.2 172 5.78418e-83 Gryllus bimaculatus semaphorin 2a (sema2a) mRNA, partial cds K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q9XZC8 849 5.3e-90 Semaphorin-2A OS=Schistocerca gregaria GN=SEMA-2A PE=2 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-12035.0 BP_3 1.00 1.18 322 823471067 XP_012425625.1 414 2.1e-38 PREDICTED: eukaryotic translation initiation factor 2 subunit 2 isoform X1 [Taeniopygia guttata] -- -- -- -- -- K03238 EIF2S2 translation initiation factor 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03238 Q5E9D0 407 5.5e-39 Eukaryotic translation initiation factor 2 subunit 2 OS=Bos taurus GN=EIF2S2 PE=2 SV=1 PF01873 Domain found in IF2B/IF5 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG2768 Translation initiation factor 2, beta subunit (eIF-2beta) Cluster-12037.0 BP_3 1.00 3.93 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00879 Defensin propeptide GO:0006952 defense response -- -- -- -- -- -- Cluster-1204.0 BP_3 3.00 0.89 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12041.0 BP_3 10.12 0.39 1547 642934722 XP_008197785.1 1306 3.7e-141 PREDICTED: uncharacterized protein LOC658747 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03340 Poxvirus rifampicin resistance protein GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-12042.0 BP_3 1.00 0.79 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12043.1 BP_3 3.00 0.34 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12046.0 BP_3 1.00 0.53 380 -- -- -- -- -- 697081306 XM_009655820.1 314 4.46863e-162 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1206.0 BP_3 3.00 0.80 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12071.1 BP_3 8.00 0.57 971 312190935 ADQ43366.1 718 3.5e-73 HMGBa [Litopenaeus vannamei] 755987004 XM_011313072.1 44 1.49149e-11 PREDICTED: Fopius arisanus high mobility group protein DSP1 (LOC105271495), transcript variant X2, mRNA K10802 HMGB1 high mobility group protein B1 http://www.genome.jp/dbget-bin/www_bget?ko:K10802 Q24537 494 1.4e-48 High mobility group protein DSP1 OS=Drosophila melanogaster GN=Dsp1 PE=2 SV=1 PF06524//PF00178//PF04690//PF02936 NOA36 protein//Ets-domain//YABBY protein//Cytochrome c oxidase subunit IV GO:0006123//GO:0007275//GO:0015992//GO:0006355 mitochondrial electron transport, cytochrome c to oxygen//multicellular organismal development//proton transport//regulation of transcription, DNA-templated GO:0003700//GO:0004129//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//cytochrome-c oxidase activity//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0045277//GO:0005634 transcription factor complex//respiratory chain complex IV//nucleus KOG0381 HMG box-containing protein Cluster-12076.0 BP_3 3.00 0.49 585 646708822 KDR14969.1 542 5.4e-53 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [Zootermopsis nevadensis] -- -- -- -- -- K03965 NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03965 Q0MQE9 325 3.2e-29 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Gorilla gorilla gorilla GN=NDUFB9 PE=2 SV=3 PF09452//PF02628 ESCRT-I subunit Mvb12//Cytochrome oxidase assembly protein GO:0055114//GO:0032509//GO:0006784 oxidation-reduction process//endosome transport via multivesicular body sorting pathway//heme a biosynthetic process GO:0016627//GO:0043130 oxidoreductase activity, acting on the CH-CH group of donors//ubiquitin binding GO:0000813//GO:0016021 ESCRT I complex//integral component of membrane KOG3466 NADH:ubiquinone oxidoreductase, NDUFB9/B22 subunit Cluster-12078.0 BP_3 2.00 0.81 410 655697654 XP_002710659.2 323 9.3e-28 PREDICTED: tribbles homolog 1 [Oryctolagus cuniculus] -- -- -- -- -- K08814 TRIB1_2 tribbles homolog 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08814 Q96RU8 317 1.9e-28 Tribbles homolog 1 OS=Homo sapiens GN=TRIB1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0583 Serine/threonine protein kinase Cluster-12081.0 BP_3 14.00 0.84 1092 475051484 AGI56293.1 137 9.2e-06 thrombospondin II [Penaeus monodon] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-12082.0 BP_3 36.00 10.93 450 238625711 ACR48137.1 642 1.0e-64 ribosomal protein S24 [Rimicaris exoculata] 225711521 BT077183.1 144 1.70789e-67 Caligus rogercresseyi clone crog-evp-503-233 40S ribosomal protein S15Aa putative mRNA, complete cds K02957 RP-S15Ae, RPS15A small subunit ribosomal protein S15Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02957 Q6XIM8 618 2.6e-63 40S ribosomal protein S15a OS=Drosophila yakuba GN=RpS15Aa PE=2 SV=3 PF00410 Ribosomal protein S8 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1754 40S ribosomal protein S15/S22 Cluster-12083.0 BP_3 9.00 32.35 274 28316886 AAL68340.2 278 1.0e-22 RH06643p, partial [Drosophila melanogaster] 338224478 HM217888.1 161 3.50021e-77 Scylla paramamosain ribosomal protein S29 CG8495-PA-like protein-like mRNA, partial sequence K02980 RP-S29e, RPS29 small subunit ribosomal protein S29e http://www.genome.jp/dbget-bin/www_bget?ko:K02980 Q9VH69 269 4.6e-23 40S ribosomal protein S29 OS=Drosophila melanogaster GN=RpS29 PE=1 SV=1 PF00253 Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3506 40S ribosomal protein S29 Cluster-12084.0 BP_3 19.00 22.04 323 769857127 XP_011640188.1 381 1.4e-34 PREDICTED: 60S ribosomal protein L37a [Pogonomyrmex barbatus] 545364453 XM_005647230.1 62 4.55273e-22 Coccomyxa subellipsoidea C-169 60S ribosomal protein L37a mRNA K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 O61598 377 1.7e-35 60S ribosomal protein L37a OS=Ostertagia ostertagi GN=rpl-37a PE=3 SV=3 PF01780//PF10717 Ribosomal L37ae protein family//Occlusion-derived virus envelope protein ODV-E18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0019031 intracellular//ribosome//viral envelope KOG0402 60S ribosomal protein L37 Cluster-12086.0 BP_3 4.00 0.31 913 -- -- -- -- -- 404312705 AC253545.1 503 0 Prunus persica clone JGIBIXB-13E11, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12088.0 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12089.0 BP_3 2.00 0.56 465 -- -- -- -- -- 16476 X52631.1 459 0 Arabidopsis thaliana DNA for rRNA intergenic region;heterogeneous EcoRI fragment -- -- -- -- -- -- -- -- PF00951 Arterivirus GL envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-121.0 BP_3 1.00 0.35 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12100.0 BP_3 2.00 0.61 450 675384854 KFM77751.1 186 7.9e-12 Neural cell adhesion molecule 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- A2AJ76 171 1.8e-11 Hemicentin-2 OS=Mus musculus GN=Hmcn2 PE=2 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-12106.0 BP_3 2.00 0.56 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01924 Hydrogenase formation hypA family -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-12107.0 BP_3 3.00 0.84 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03214 Reversibly glycosylated polypeptide GO:0030244 cellulose biosynthetic process GO:0016866 intramolecular transferase activity -- -- -- -- Cluster-12113.0 BP_3 7.00 0.60 852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12118.0 BP_3 18.00 0.89 1264 270015451 EFA11899.1 200 5.3e-13 hypothetical protein TcasGA2_TC004056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12124.0 BP_3 2.00 1.61 346 704301209 XP_010162934.1 380 1.9e-34 PREDICTED: uncharacterized protein LOC104522366, partial [Caprimulgus carolinensis] 313184264 FN823234.1 247 7.08736e-125 Malus x domestica genomic sequence for BAC clone MC-12 containing a Mal d 1 gene cluster -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12146.0 BP_3 4.00 1.38 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12150.0 BP_3 20.00 0.59 1923 664761724 XP_008538493.1 210 5.6e-14 PREDICTED: pepsin A [Equus przewalskii] 42742378 AY524792.1 1923 0 Verticillium dahliae aspartic protease-like protein mRNA, complete cds -- -- -- -- Q4WDN4 319 5.3e-28 Probable aspartic-type endopeptidase opsB OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=opsB PE=3 SV=1 PF00026 Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG1339 Aspartyl protease Cluster-12159.0 BP_3 7.00 1.02 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12163.0 BP_3 3.00 0.47 602 512914353 XP_004928121.1 666 2.3e-67 PREDICTED: MORN repeat-containing protein 4 [Bombyx mori] -- -- -- -- -- -- -- -- -- Q6PGF2 410 4.6e-39 MORN repeat-containing protein 4 OS=Mus musculus GN=Morn4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-12169.0 BP_3 1.00 0.31 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12171.0 BP_3 10.53 0.37 1656 270002303 EEZ98750.1 1493 8.1e-163 hypothetical protein TcasGA2_TC001311 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02864//PF00211 STAT protein, DNA binding domain//Adenylate and Guanylate cyclase catalytic domain GO:0006355//GO:0035556//GO:0009190//GO:0007165 regulation of transcription, DNA-templated//intracellular signal transduction//cyclic nucleotide biosynthetic process//signal transduction GO:0004871//GO:0003700//GO:0016849 signal transducer activity//transcription factor activity, sequence-specific DNA binding//phosphorus-oxygen lyase activity GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-12173.0 BP_3 5.00 0.34 997 6165618 AAF04618.1 1294 5.8e-140 gamma-interferon inducible lysosomal thiol reductase [Homo sapiens] 523498473 NM_006332.4 974 0 Homo sapiens interferon, gamma-inducible protein 30 (IFI30), mRNA K08059 IFI30, GILT interferon, gamma-inducible protein 30 http://www.genome.jp/dbget-bin/www_bget?ko:K08059 P13284 1252 1.8e-136 Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens GN=IFI30 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-12193.0 BP_3 2.62 0.31 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-12195.0 BP_3 2.00 2.24 325 -- -- -- -- -- 55296639 AP006751.2 307 2.92757e-158 Oryza sativa Japonica Group genomic DNA, chromosome 6, BAC clone:B1460A05 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-122.0 BP_3 11.00 1.42 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1220.0 BP_3 7.00 0.64 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01907 Ribosomal protein L37e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-12204.1 BP_3 20.31 5.87 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12206.0 BP_3 7.29 0.57 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12207.0 BP_3 16.00 0.41 2172 -- -- -- -- -- 697074008 XM_009653302.1 1894 0 Verticillium dahliae VdLs.17 mannan endo-1,6-alpha-mannosidase DCW1 partial mRNA -- -- -- -- P36091 1045 3.9e-112 Mannan endo-1,6-alpha-mannosidase DCW1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCW1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-12210.0 BP_3 2.00 0.54 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12212.0 BP_3 3.00 0.94 445 194376884 BAG63003.1 755 8.2e-78 unnamed protein product [Homo sapiens] 194376883 AK301492.1 439 0 Homo sapiens cDNA FLJ51122 complete cds, highly similar to Interleukin-10 receptor alpha chain precursor K05134 IL10RA interleukin 10 receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05134 Q13651 755 3.4e-79 Interleukin-10 receptor subunit alpha OS=Homo sapiens GN=IL10RA PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-12214.0 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12215.0 BP_3 2.00 0.47 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12220.0 BP_3 1.00 0.35 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12221.0 BP_3 3.00 0.37 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12225.0 BP_3 3.00 0.58 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12226.0 BP_3 5.00 0.57 712 187131234 NP_001119631.1 433 2.9e-40 cytochrome c-like protein [Acyrthosiphon pisum]>gi|89574471|gb|ABD76366.1| cytochrome c-like protein [Acyrthosiphon pisum]>gi|239789815|dbj|BAH71507.1| ACYPI000041 [Acyrthosiphon pisum] 697065808 XM_009649796.1 700 0 Verticillium dahliae VdLs.17 cytochrome c mRNA K08738 CYC cytochrome c http://www.genome.jp/dbget-bin/www_bget?ko:K08738 Q4HVX7 528 1.1e-52 Cytochrome c OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) GN=CYC1 PE=3 SV=2 PF13442//PF00034 Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome c GO:0022900//GO:0006118 electron transport chain//obsolete electron transport GO:0009055//GO:0020037//GO:0005506 electron carrier activity//heme binding//iron ion binding GO:0070469//GO:0005739 respiratory chain//mitochondrion KOG3453 Cytochrome c Cluster-12229.0 BP_3 2.00 0.51 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12231.0 BP_3 3.00 0.32 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12234.0 BP_3 1.00 0.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12238.0 BP_3 3.00 0.56 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12106 Colicin C terminal ribonuclease domain GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity -- -- -- -- Cluster-12244.0 BP_3 2.00 0.45 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12248.0 BP_3 6.00 1.00 582 546683997 ERL93731.1 877 7.6e-92 hypothetical protein D910_11017, partial [Dendroctonus ponderosae] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P39057 755 4.4e-79 Dynein beta chain, ciliary OS=Heliocidaris crassispina PE=1 SV=1 PF07728 AAA domain (dynein-related subfamily) -- -- GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- -- -- Cluster-12249.0 BP_3 2.00 0.31 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12252.0 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1226.0 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12261.1 BP_3 48.00 0.85 3008 330795076 XP_003285601.1 1985 1.3e-219 hypothetical protein DICPUDRAFT_46211 [Dictyostelium purpureum]>gi|325084423|gb|EGC37851.1| hypothetical protein DICPUDRAFT_46211 [Dictyostelium purpureum] 768311755 CP010983.1 2971 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- P31540 3483 0.0e+00 Heat shock protein hsp98 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hsp98 PE=1 SV=2 PF07724//PF00448//PF00437//PF00910//PF01637//PF04851//PF00005//PF07726//PF03266//PF02861//PF03193//PF06309//PF00004//PF13304//PF00158//PF01695//PF07728//PF08477//PF02367//PF06414 AAA domain (Cdc48 subfamily)//SRP54-type protein, GTPase domain//Type II/IV secretion system protein//RNA helicase//Archaeal ATPase//Type III restriction enzyme, res subunit//ABC transporter//ATPase family associated with various cellular activities (AAA)//NTPase//Clp amino terminal domain, pathogenicity island component//Protein of unknown function, DUF258//Torsin//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin GO:0019538//GO:0006355//GO:0006810//GO:0006614//GO:0007264//GO:0002949 protein metabolic process//regulation of transcription, DNA-templated//transport//SRP-dependent cotranslational protein targeting to membrane//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification GO:0016887//GO:0016301//GO:0008134//GO:0003924//GO:0098519//GO:0016787//GO:0005524//GO:0003724//GO:0005525//GO:0003677//GO:0003723 ATPase activity//kinase activity//transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//hydrolase activity//ATP binding//RNA helicase activity//GTP binding//DNA binding//RNA binding GO:0005667 transcription factor complex KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases Cluster-12261.2 BP_3 16.00 0.83 1224 -- -- -- -- -- 697089892 XM_009659560.1 1215 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-12261.3 BP_3 12.00 0.60 1252 -- -- -- -- -- 768311759 CP010987.1 1246 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12262.0 BP_3 16.00 0.95 1100 340367953 XP_003382517.1 747 1.7e-76 PREDICTED: 60S ribosomal protein L15-like [Amphimedon queenslandica] 697089716 XM_009659472.1 823 0 Verticillium dahliae VdLs.17 60S ribosomal protein L15-B partial mRNA K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 Q8X034 942 1.7e-100 60S ribosomal protein L15 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-15 PE=3 SV=1 PF00827 Ribosomal L15 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-12263.0 BP_3 9.00 0.35 1518 328796226 AEB40302.1 1250 1.1e-134 mitochondrial ATP synthase gamma subunit precursor [Litopenaeus vannamei] 577029966 KF648350.1 59 1.08251e-19 Biomphalaria glabrata ATP synthase subunit mitochondrial-like protein mRNA, partial cds K02136 ATPeF1G, ATP5C1, ATP3 F-type H+-transporting ATPase subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K02136 O01666 926 1.7e-98 ATP synthase subunit gamma, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-gamma PE=2 SV=2 PF00231 ATP synthase GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1531 F0F1-type ATP synthase, gamma subunit Cluster-12265.0 BP_3 4.00 0.37 815 478263033 ENN81433.1 707 5.5e-72 hypothetical protein YQE_02126, partial [Dendroctonus ponderosae]>gi|546686062|gb|ERL95462.1| hypothetical protein D910_12724 [Dendroctonus ponderosae] 697088158 XM_009658695.1 745 0 Verticillium dahliae VdLs.17 malate dehydrogenase partial mRNA K00026 MDH2 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00026 P83778 668 7.6e-69 Malate dehydrogenase, cytoplasmic OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDH1 PE=1 SV=2 PF00056//PF02866 lactate/malate dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0016616 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-12266.0 BP_3 1.00 0.33 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12268.0 BP_3 9.00 0.60 1019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12276.0 BP_3 20.24 0.34 3185 270004958 EFA01406.1 255 5.6e-19 odorant receptor 221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949 7tm Odorant receptor GO:0007608//GO:0007187 sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016020 membrane -- -- Cluster-12277.1 BP_3 3.00 0.55 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12282.0 BP_3 2.00 0.83 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12287.0 BP_3 4.00 0.98 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12292.0 BP_3 4.00 0.52 666 -- -- -- -- -- 768311759 CP010987.1 666 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-12296.0 BP_3 5.00 0.54 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07552 Spore Coat Protein X and V domain GO:0030435 sporulation resulting in formation of a cellular spore -- -- GO:0031160 spore wall -- -- Cluster-12299.0 BP_3 1.00 0.46 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12308.1 BP_3 5.00 0.35 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12309.0 BP_3 5.00 0.88 565 744603787 XP_010991488.1 860 6.9e-90 PREDICTED: 40S ribosomal protein S11 [Camelus dromedarius] 395132454 NM_001015.4 565 0 Homo sapiens ribosomal protein S11 (RPS11), mRNA K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P62280 824 4.3e-87 40S ribosomal protein S11 OS=Homo sapiens GN=RPS11 PE=1 SV=3 PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1728 40S ribosomal protein S11 Cluster-1231.0 BP_3 4.00 2.51 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12310.0 BP_3 2.00 0.31 600 470292237 XP_004343574.1 496 1.2e-47 microtubule associated protein [Capsaspora owczarzaki ATCC 30864]>gi|765556954|gb|KJE97263.1| microtubule associated protein [Capsaspora owczarzaki ATCC 30864] 697066438 XM_009650111.1 591 0 Verticillium dahliae VdLs.17 Microtubule associated protein mRNA K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 Q8WZY7 613 1.3e-62 Autophagy-related protein 8 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=apg-6 PE=3 SV=1 PF04110 Ubiquitin-like autophagy protein Apg12 GO:0000045 autophagosome assembly -- -- GO:0005737 cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-12314.0 BP_3 4.00 0.38 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1232.0 BP_3 118.00 10.97 810 546685904 ERL95326.1 273 1.2e-21 hypothetical protein D910_12592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12328.1 BP_3 17.92 0.40 2455 478267817 ENN83104.1 727 8.0e-74 hypothetical protein YQE_00535, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12335.0 BP_3 3.00 0.51 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12337.0 BP_3 2.00 0.31 607 242003126 XP_002422619.1 463 8.1e-44 conserved hypothetical protein [Pediculus humanus corporis]>gi|212505420|gb|EEB09881.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q96T92 284 1.9e-24 Insulinoma-associated protein 2 OS=Homo sapiens GN=INSM2 PE=1 SV=3 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- KOG3993 Transcription factor (contains Zn finger) Cluster-12342.0 BP_3 2.00 0.32 595 630044959 AHY88456.1 150 1.6e-07 gsc [Novocrania anomala] 697068427 XM_009651103.1 592 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- Q8VIH1 131 1.0e-06 Homeobox protein NOBOX OS=Mus musculus GN=Nobox PE=1 SV=1 PF01496//PF00046//PF01080//PF05920 V-type ATPase 116kDa subunit family//Homeobox domain//Presenilin//Homeobox KN domain GO:0015991//GO:0015992//GO:0006355 ATP hydrolysis coupled proton transport//proton transport//regulation of transcription, DNA-templated GO:0004190//GO:0003677//GO:0015078 aspartic-type endopeptidase activity//DNA binding//hydrogen ion transmembrane transporter activity GO:0016021//GO:0033179 integral component of membrane//proton-transporting V-type ATPase, V0 domain KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains Cluster-12344.0 BP_3 8.00 0.43 1192 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12352.0 BP_3 1.00 0.35 427 725571770 XP_010338387.1 564 1.1e-55 PREDICTED: LOW QUALITY PROTEIN: 60S ribosomal protein L34 [Saimiri boliviensis boliviensis] 578809310 XM_005263172.2 426 0 PREDICTED: Homo sapiens ribosomal protein L34 (RPL34), transcript variant X1, mRNA K02915 RP-L34e, RPL34 large subunit ribosomal protein L34e http://www.genome.jp/dbget-bin/www_bget?ko:K02915 P49207 524 2.0e-52 60S ribosomal protein L34 OS=Homo sapiens GN=RPL34 PE=1 SV=3 PF08534//PF01199 Redoxin//Ribosomal protein L34e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0016491 structural constituent of ribosome//oxidoreductase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1790 60s ribosomal protein L34 Cluster-12355.0 BP_3 3.00 0.38 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12357.0 BP_3 2.00 0.59 454 -- -- -- -- -- 768311755 CP010983.1 454 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12362.1 BP_3 63.73 1.62 2192 642931676 XP_008196683.1 173 1.2e-09 PREDICTED: uncharacterized protein LOC103313928 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-12365.0 BP_3 2.00 0.51 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12367.0 BP_3 2.00 0.77 416 -- -- -- -- -- 768311752 CP010980.1 416 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12368.0 BP_3 3.00 0.61 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12368.2 BP_3 1.00 0.39 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12371.0 BP_3 2.00 0.33 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12376.0 BP_3 3.25 0.46 635 826438677 XP_012529854.1 266 5.9e-21 PREDICTED: prostaglandin reductase 1-like, partial [Monomorium pharaonis] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q9EQZ5 176 6.6e-12 Prostaglandin reductase 1 OS=Cavia porcellus GN=Ptgr1 PE=1 SV=1 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG1196 Predicted NAD-dependent oxidoreductase Cluster-12377.0 BP_3 1.00 0.61 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12387.0 BP_3 2.00 1.00 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12388.0 BP_3 5.00 0.34 998 478257368 ENN77526.1 502 4.0e-48 hypothetical protein YQE_05974, partial [Dendroctonus ponderosae]>gi|546685339|gb|ERL94866.1| hypothetical protein D910_12139 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5VTB9 231 4.4e-18 E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens GN=RNF220 PE=1 SV=1 PF11789//PF13639//PF14634//PF12678//PF00097 Zinc-finger of the MIZ type in Nse subunit//Ring finger domain//zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-12396.0 BP_3 7.00 0.32 1346 -- -- -- -- -- 392303567 JX102600.1 650 0 Scylla paramamosain microsatellite Spm29 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12399.0 BP_3 4.00 0.31 907 -- -- -- -- -- 697086183 XM_009657709.1 601 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12400.0 BP_3 20.00 0.71 1640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12400.1 BP_3 11.00 0.49 1375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12412.0 BP_3 20.01 0.45 2450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12414.0 BP_3 3.00 0.33 727 119602027 EAW81621.1 548 1.3e-53 T-cell leukemia/lymphoma 1A, isoform CRA_a [Homo sapiens] 148922878 NM_001098725.1 727 0 Homo sapiens T-cell leukemia/lymphoma 1A (TCL1A), transcript variant 2, mRNA K10167 TCL1A T-cell leukemia/lymphoma 1A http://www.genome.jp/dbget-bin/www_bget?ko:K10167 P56279 314 7.5e-28 T-cell leukemia/lymphoma protein 1A OS=Homo sapiens GN=TCL1A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-12416.0 BP_3 5.00 0.50 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12418.0 BP_3 10.00 0.42 1437 348514686 XP_003444871.1 1675 5.5e-184 PREDICTED: heat shock 70 kDa protein-like [Oreochromis niloticus] 697066190 XM_009649987.1 926 0 Verticillium dahliae VdLs.17 heat shock protein sks2 mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11142 1658 2.1e-183 Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 PF02782//PF06723 FGGY family of carbohydrate kinases, C-terminal domain//MreB/Mbl protein GO:0000902//GO:0005975 cell morphogenesis//carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-12418.1 BP_3 11.00 0.64 1122 831759145 XP_012749557.1 692 4.2e-70 hypothetical protein SAMD00019534_106680 [Acytostelium subglobosum LB1]>gi|735994323|dbj|GAM27492.1| hypothetical protein SAMD00019534_106680 [Acytostelium subglobosum LB1] 697066190 XM_009649987.1 1119 0 Verticillium dahliae VdLs.17 heat shock protein sks2 mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P87222 1080 1.8e-116 Heat shock protein SSB1 OS=Candida albicans (strain WO-1) GN=SSB1 PE=3 SV=2 PF02782 FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-12419.0 BP_3 1.00 0.40 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1242.0 BP_3 5.00 0.65 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12433.0 BP_3 3.00 0.42 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12435.0 BP_3 3.00 0.31 758 321459636 EFX70687.1 320 3.8e-27 hypothetical protein DAPPUDRAFT_3267, partial [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-12446.0 BP_3 8.00 0.84 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12460.0 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12465.0 BP_3 9.00 0.54 1095 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1247.0 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12474.0 BP_3 3.00 0.40 654 321479073 EFX90029.1 239 8.2e-18 hypothetical protein DAPPUDRAFT_190063 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q99LS1 175 8.9e-12 Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial OS=Mus musculus GN=Mmadhc PE=2 SV=1 PF10229 Uncharacterized conserved protein (DUF2246) GO:0009235 cobalamin metabolic process -- -- -- -- -- -- Cluster-12478.0 BP_3 1.00 0.92 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12481.0 BP_3 4.00 1.09 468 221139854 NP_001034527.2 184 1.4e-11 protein krueppel [Tribolium castaneum]>gi|270001305|gb|EEZ97752.1| kruppel [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005488 binding -- -- -- -- Cluster-12495.0 BP_3 9.00 0.34 1576 91076012 XP_966490.1 1129 1.2e-120 PREDICTED: succinyl-CoA ligase subunit alpha, mitochondrial [Tribolium castaneum]>gi|91076014|ref|XP_975865.1| PREDICTED: succinyl-CoA ligase subunit alpha, mitochondrial [Tribolium castaneum]>gi|270014681|gb|EFA11129.1| hypothetical protein TcasGA2_TC004730 [Tribolium castaneum] 573952920 XM_006658670.1 101 5.05153e-43 PREDICTED: Oryza brachyantha probable succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial-like (LOC102706771), partial mRNA K01899 LSC1 succinyl-CoA synthetase alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01899 P13086 1060 5.1e-114 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Rattus norvegicus GN=Suclg1 PE=2 SV=2 PF02629//PF00549//PF13380 CoA binding domain//CoA-ligase//CoA binding domain GO:0006099//GO:0008152//GO:0019643 tricarboxylic acid cycle//metabolic process//reductive tricarboxylic acid cycle GO:0004775//GO:0000166//GO:0048037//GO:0003878//GO:0003824 succinate-CoA ligase (ADP-forming) activity//nucleotide binding//cofactor binding//ATP citrate synthase activity//catalytic activity GO:0042709 succinate-CoA ligase complex KOG1255 Succinyl-CoA synthetase, alpha subunit Cluster-12496.0 BP_3 7.00 1.29 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-125.0 BP_3 9.00 0.53 1109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1250.0 BP_3 3.00 0.90 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12504.0 BP_3 13.00 6.14 392 328899610 AEB54642.1 468 1.4e-44 ribosomal protein L35 [Procambarus clarkii] 262401437 FJ774901.1 388 0 Scylla paramamosain ribosomal protein L35 mRNA, complete cds K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 Q6ZWV7 351 2.1e-32 60S ribosomal protein L35 OS=Mus musculus GN=Rpl35 PE=2 SV=1 PF00831//PF00466 Ribosomal L29 protein//Ribosomal protein L10 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3436 60S ribosomal protein L35 Cluster-12506.0 BP_3 1.00 0.85 342 470306014 XP_004363340.1 171 3.3e-10 hypothetical protein CAOG_03612 [Capsaspora owczarzaki ATCC 30864]>gi|765552076|gb|KJE92697.1| hypothetical protein CAOG_003612 [Capsaspora owczarzaki ATCC 30864] 697076615 XM_009654199.1 302 1.86452e-155 Verticillium dahliae VdLs.17 NADH:ubiquinone oxidoreductase 11.5kD subunit partial mRNA -- -- -- -- -- -- -- -- PF02297//PF00941 Cytochrome oxidase c subunit VIb//FAD binding domain in molybdopterin dehydrogenase GO:0006123//GO:0055114//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//oxidation-reduction process//proton transport GO:0016491//GO:0004129 oxidoreductase activity//cytochrome-c oxidase activity GO:0045277//GO:0005739 respiratory chain complex IV//mitochondrion -- -- Cluster-12510.0 BP_3 2.00 0.33 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12511.0 BP_3 5.00 0.85 574 157118570 XP_001653203.1 208 2.8e-14 AAEL008353-PB [Aedes aegypti]>gi|157118572|ref|XP_001653204.1| AAEL008353-PA [Aedes aegypti]>gi|94468574|gb|ABF18136.1| ribosomal protein L28 [Aedes aegypti]>gi|108875657|gb|EAT39882.1| AAEL008353-PB [Aedes aegypti]>gi|108875658|gb|EAT39883.1| AAEL008353-PA [Aedes aegypti] 697088156 XM_009658694.1 560 0 Verticillium dahliae VdLs.17 60S ribosomal protein L28 mRNA -- -- -- -- O82204 221 3.6e-17 60S ribosomal protein L28-1 OS=Arabidopsis thaliana GN=RPL28A PE=2 SV=1 PF05722 Ustilago B locus mating-type protein -- -- GO:0003677 DNA binding GO:0005634 nucleus KOG3412 60S ribosomal protein L28 Cluster-12517.0 BP_3 4.00 0.36 825 -- -- -- -- -- 768311752 CP010980.1 593 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- PF02565 Recombination protein O C terminal GO:0006281//GO:0006310 DNA repair//DNA recombination -- -- -- -- -- -- Cluster-12526.0 BP_3 2.00 0.32 589 351708904 EHB11823.1 512 1.6e-49 Protein yippee-like 3 [Heterocephalus glaber] 224465221 NM_001145524.1 589 0 Homo sapiens yippee-like 3 (YPEL3), transcript variant 2, mRNA -- -- -- -- Q65Z57 454 3.6e-44 Protein yippee-like 3 OS=Chlorocebus aethiops GN=YPEL3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-12531.0 BP_3 4.00 0.89 507 -- -- -- -- -- 573984618 XM_006670167.1 39 4.54236e-09 Cordyceps militaris CM01 hypothetical protein (CCM_05022), partial mRNA -- -- -- -- -- -- -- -- PF16934//PF00272//PF01557 Two-component Enterococcus faecalis cytolysin (EFC)//Cecropin family//Fumarylacetoacetate (FAA) hydrolase family GO:0050830//GO:0008152 defense response to Gram-positive bacterium//metabolic process GO:0003824 catalytic activity GO:0005576 extracellular region -- -- Cluster-12535.0 BP_3 7.00 0.46 1028 321467446 EFX78436.1 1065 2.1e-113 hypothetical protein DAPPUDRAFT_305161 [Daphnia pulex] 56306665 CR726103.2 37 1.23182e-07 Tetraodon nigroviridis full-length cDNA K03247 EIF3H translation initiation factor 3 subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K03247 Q9GV27 1046 1.4e-112 Eukaryotic translation initiation factor 3 subunit H OS=Bombyx mori PE=2 SV=1 PF02116//PF01398//PF09207 Fungal pheromone mating factor STE2 GPCR//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Yeast killer toxin GO:0009405//GO:0007186//GO:0008219//GO:0019236//GO:0007606 pathogenesis//G-protein coupled receptor signaling pathway//cell death//response to pheromone//sensory perception of chemical stimulus GO:0005515//GO:0004932 protein binding//mating-type factor pheromone receptor activity GO:0005576//GO:0016020 extracellular region//membrane KOG1560 Translation initiation factor 3, subunit h (eIF-3h) Cluster-12544.0 BP_3 3.00 0.33 730 820148621 KKX14810.1 140 2.8e-06 sterol regulatory element-binding protein 1 [Scleropages formosus] 697068874 XM_009651326.1 541 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- Q9UUD1 211 6.7e-16 Sterol regulatory element-binding protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sre1 PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG2588 Predicted DNA-binding protein Cluster-12547.0 BP_3 1.00 0.39 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12548.0 BP_3 29.00 0.77 2105 642929675 XP_008195931.1 392 4.8e-35 PREDICTED: uncharacterized protein LOC103313712 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12551.0 BP_3 6.14 0.51 867 642937440 XP_008198835.1 230 1.2e-16 PREDICTED: uncharacterized protein LOC103314468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04825 N terminus of Rad21 / Rec8 like protein -- -- GO:0005515 protein binding -- -- -- -- Cluster-12558.1 BP_3 4.00 0.31 910 356651196 AET34915.1 384 1.8e-34 heat shock protein 21 [Macrobrachium rosenbergii] -- -- -- -- -- -- -- -- -- P02515 158 1.2e-09 Heat shock protein 22 OS=Drosophila melanogaster GN=Hsp22 PE=1 SV=4 PF03153//PF00108 Transcription factor IIA, alpha/beta subunit//Thiolase, N-terminal domain GO:0008152//GO:0006367 metabolic process//transcription initiation from RNA polymerase II promoter GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0005672 transcription factor TFIIA complex -- -- Cluster-12564.0 BP_3 22.00 2.29 755 187179331 NP_001119643.1 704 1.1e-71 ribosomal protein L12 [Acyrthosiphon pisum]>gi|89574483|gb|ABD76372.1| putative ribosomal protein L12e [Acyrthosiphon pisum]>gi|239788182|dbj|BAH70782.1| ACYPI000059 [Acyrthosiphon pisum] 262401300 FJ774832.1 519 0 Scylla paramamosain ribosomal protein L12 mRNA, complete cds K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61866 661 4.5e-68 60S ribosomal protein L12 OS=Caenorhabditis elegans GN=rpl-12 PE=3 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-12565.0 BP_3 2.00 0.78 415 -- -- -- -- -- 1502302 X89530.1 111 3.45929e-49 Apis mellifera carnica DNA for Ava I repeat -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12566.0 BP_3 4.00 0.67 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12571.0 BP_3 5.02 0.40 902 642932613 XP_968153.2 786 4.2e-81 PREDICTED: uncharacterized protein LOC656535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91ZX7 126 5.9e-06 Prolow-density lipoprotein receptor-related protein 1 OS=Mus musculus GN=Lrp1 PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-12575.2 BP_3 5.00 0.50 778 281208281 EFA82459.1 436 1.4e-40 5-methyltetrahydropteroyltriglutamate-homocysteine-S-methyltransferase [Polysphondylium pallidum PN500] 697084510 XM_009656938.1 461 0 Verticillium dahliae VdLs.17 Cobalamin-independent synthase partial mRNA -- -- -- -- P82610 475 1.7e-46 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MET6 PE=1 SV=2 PF08267 Cobalamin-independent synthase, N-terminal domain GO:0008652//GO:0009086 cellular amino acid biosynthetic process//methionine biosynthetic process GO:0008270//GO:0003871 zinc ion binding//5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity -- -- KOG2263 Methionine synthase II (cobalamin-independent) Cluster-12583.0 BP_3 28.00 6.87 488 268306400 ACY95321.1 305 1.4e-25 ribosomal protein L28 [Manduca sexta] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 293 1.4e-25 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-12586.0 BP_3 6.00 0.74 680 557751038 XP_005175277.1 429 7.9e-40 PREDICTED: ATP synthase subunit d, mitochondrial-like [Musca domestica]>gi|557772473|ref|XP_005185893.1| PREDICTED: ATP synthase subunit d, mitochondrial-like [Musca domestica]>gi|557772475|ref|XP_005185894.1| PREDICTED: ATP synthase subunit d, mitochondrial-like [Musca domestica] -- -- -- -- -- K02138 ATPeF0D, ATP5H, ATP7 F-type H+-transporting ATPase subunit d http://www.genome.jp/dbget-bin/www_bget?ko:K02138 Q24251 381 1.2e-35 ATP synthase subunit d, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-d PE=2 SV=2 PF08202 Mis12-Mtw1 protein family GO:0051301//GO:0007059 cell division//chromosome segregation -- -- GO:0000444 MIS12/MIND type complex KOG3366 Mitochondrial F1F0-ATP synthase, subunit d/ATP7 Cluster-12589.0 BP_3 3.00 0.63 522 242006139 XP_002423912.1 580 1.9e-57 syntaxin-1A, putative [Pediculus humanus corporis]>gi|212507175|gb|EEB11174.1| syntaxin-1A, putative [Pediculus humanus corporis] 645014656 XM_008205349.1 71 7.60474e-27 PREDICTED: Nasonia vitripennis syntaxin-1A (LOC100121257), transcript variant X3, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 541 2.6e-54 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF04111//PF04871//PF00804//PF09177//PF01323//PF04136//PF15898//PF07851//PF06009//PF05478//PF01496//PF01920//PF03938//PF09036//PF04799//PF01499//PF08702//PF04513//PF03233//PF08074 Autophagy protein Apg6//Uso1 / p115 like vesicle tethering protein, C terminal region//Syntaxin//Syntaxin 6, N-terminal//DSBA-like thioredoxin domain//Sec34-like family//cGMP-dependent protein kinase interacting domain//TMPIT-like protein//Laminin Domain II//Prominin//V-type ATPase 116kDa subunit family//Prefoldin subunit//Outer membrane protein (OmpH-like)//Bcr-Abl oncoprotein oligomerisation domain//fzo-like conserved region//Herpesvirus UL25 family//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Aphid transmission protein//CHDCT2 (NUC038) domain GO:0016310//GO:0048193//GO:0019089//GO:0030168//GO:0008053//GO:0019072//GO:0015992//GO:0006118//GO:0015991//GO:0006457//GO:0007155//GO:0006886//GO:0016192//GO:0006810//GO:0051258//GO:0006468//GO:0006914//GO:0009069//GO:0007165//GO:0015031//GO:0006355 phosphorylation//Golgi vesicle transport//transmission of virus//platelet activation//mitochondrial fusion//viral genome packaging//proton transport//obsolete electron transport//ATP hydrolysis coupled proton transport//protein folding//cell adhesion//intracellular protein transport//vesicle-mediated transport//transport//protein polymerization//protein phosphorylation//autophagy//serine family amino acid metabolic process//signal transduction//protein transport//regulation of transcription, DNA-templated GO:0005484//GO:0030674//GO:0003924//GO:0005524//GO:0004674//GO:0005102//GO:0051082//GO:0003677//GO:0015035//GO:0005198//GO:0005096//GO:0016818//GO:0015078//GO:0019901//GO:0008565//GO:0008270 SNAP receptor activity//protein binding, bridging//GTPase activity//ATP binding//protein serine/threonine kinase activity//receptor binding//unfolded protein binding//DNA binding//protein disulfide oxidoreductase activity//structural molecule activity//GTPase activator activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//hydrogen ion transmembrane transporter activity//protein kinase binding//protein transporter activity//zinc ion binding GO:0019028//GO:0005577//GO:0016272//GO:0019031//GO:0005634//GO:0033179//GO:0016020//GO:0005741//GO:0042025//GO:0016021//GO:0005737//GO:0005801//GO:0005622 viral capsid//fibrinogen complex//prefoldin complex//viral envelope//nucleus//proton-transporting V-type ATPase, V0 domain//membrane//mitochondrial outer membrane//host cell nucleus//integral component of membrane//cytoplasm//cis-Golgi network//intracellular KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-126.0 BP_3 8.00 0.59 946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-126.1 BP_3 6.00 4.56 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12616.0 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12617.0 BP_3 3.00 1.46 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12618.0 BP_3 1.00 0.79 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12622.0 BP_3 10.00 0.76 924 -- -- -- -- -- 768311759 CP010987.1 754 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12625.0 BP_3 3.00 0.33 724 21666702 AAM73800.1 198 5.2e-13 SCYLLA-like protein [Penaeus monodon] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-12628.0 BP_3 4.43 0.50 718 -- -- -- -- -- 88605020 DQ386641.1 265 1.52656e-134 Apriona germari transferrin gene, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12642.0 BP_3 4.00 0.31 911 -- -- -- -- -- 768311754 CP010982.1 905 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12648.0 BP_3 12.00 0.49 1468 478255344 ENN75570.1 521 3.7e-50 hypothetical protein YQE_07913, partial [Dendroctonus ponderosae] -- -- -- -- -- K10420 DYNLT dynein light chain Tctex-type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10420 Q94524 399 2.1e-37 Dynein light chain Tctex-type OS=Drosophila melanogaster GN=Dlc90F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4081 Dynein light chain Cluster-12651.0 BP_3 11.94 0.41 1688 642923870 XP_008193363.1 703 3.3e-71 PREDICTED: protein FAM92A1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LU86 435 1.6e-41 Protein FAM92A1 OS=Danio rerio GN=fam92a1 PE=2 SV=1 PF15003//PF07201 HAUS augmin-like complex subunit 2//HrpJ-like domain GO:0031023//GO:0046903//GO:0051225//GO:0009405 microtubule organizing center organization//secretion//spindle assembly//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-12652.0 BP_3 63.83 2.48 1532 642931465 XP_008196595.1 1418 3.7e-154 PREDICTED: uncharacterized protein LOC103313903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12660.0 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12662.0 BP_3 7.00 0.37 1215 806629217 AKB96212.1 1408 4.3e-153 heat shock protein cognate 3 [Cherax destructor] 443614324 JQ864187.1 757 0 Scylla paramamosain clone PXL009A01 70kD heat shock protein mRNA, partial cds K09490 HSPA5, BIP heat shock 70kDa protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09490 P29844 1304 2.0e-142 Heat shock 70 kDa protein cognate 3 OS=Drosophila melanogaster GN=Hsc70-3 PE=2 SV=2 PF02782 FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG0100 Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily Cluster-12665.0 BP_3 1.00 1.65 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12668.0 BP_3 9.00 0.81 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12672.0 BP_3 4.00 0.41 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12672.1 BP_3 2.00 1.01 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12675.0 BP_3 4.00 1.08 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12677.0 BP_3 3.00 0.31 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12683.0 BP_3 3.00 0.87 458 646723943 KDR24377.1 475 2.5e-45 Muscle M-line assembly protein unc-89 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O01761 188 1.9e-13 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-12687.0 BP_3 6.00 0.44 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12700.0 BP_3 5.00 0.36 967 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12703.0 BP_3 7.00 0.97 639 -- -- -- -- -- 50399589 AL731739.4 626 0 Oryza sativa chromosome 12, . BAC OSJNBa0056I18 of library OSJNBa from chromosome 12 of cultivar Nipponbare of ssp. japonica of Oryza sativa (rice), complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12714.0 BP_3 7.25 0.86 700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12716.0 BP_3 4.00 0.36 824 270015185 EFA11633.1 173 4.6e-10 hypothetical protein TcasGA2_TC000011 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1272.0 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12723.0 BP_3 3.00 0.70 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11522 Yeast phosphatidylinositol-4-OH kinase Pik1 -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-12728.0 BP_3 6.00 0.64 747 762073480 XP_011433871.1 249 6.5e-19 PREDICTED: 60S ribosomal protein L14-like [Crassostrea gigas] 697073604 XM_009653160.1 706 0 Verticillium dahliae VdLs.17 60S ribosomal protein L14-B mRNA K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 P36105 312 1.3e-27 60S ribosomal protein L14-A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL14A PE=1 SV=1 PF01929 Ribosomal protein L14 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3421 60S ribosomal protein L14 Cluster-1273.0 BP_3 3.00 1.55 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12735.0 BP_3 3.00 0.60 533 91092962 XP_972771.1 523 7.8e-51 PREDICTED: protein translation factor SUI1 homolog [Tribolium castaneum]>gi|270003114|gb|EEZ99561.1| hypothetical protein TcasGA2_TC000143 [Tribolium castaneum] -- -- -- -- -- K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 P42678 511 7.9e-51 Protein translation factor SUI1 homolog OS=Anopheles gambiae GN=AGAP006459 PE=3 SV=1 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-12743.0 BP_3 7.00 2.02 458 694539621 XP_009496519.1 230 6.3e-17 30S ribosomal protein S14p/S29e [Fonticula alba]>gi|627946968|gb|KCV68948.1| 30S ribosomal protein S14p/S29e [Fonticula alba] 697066902 XM_009650343.1 449 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA K02980 RP-S29e, RPS29 small subunit ribosomal protein S29e http://www.genome.jp/dbget-bin/www_bget?ko:K02980 Q9C2P2 274 2.1e-23 40S ribosomal protein S29 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-29 PE=3 SV=1 PF00253 Ribosomal protein S14p/S29e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3506 40S ribosomal protein S29 Cluster-12750.0 BP_3 3.00 0.46 606 751799203 XP_011209552.1 624 1.7e-62 PREDICTED: V-type proton ATPase subunit E [Bactrocera dorsalis]>gi|751799205|ref|XP_011209553.1| PREDICTED: V-type proton ATPase subunit E [Bactrocera dorsalis] 229366961 BT082754.1 105 1.1209e-45 Anoplopoma fimbria clone afim-evh-535-162 Vacuolar proton pump subunit E 1 putative mRNA, complete cds K02150 ATPeV1E, ATP6E V-type H+-transporting ATPase subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K02150 P54611 597 9.6e-61 V-type proton ATPase subunit E OS=Drosophila melanogaster GN=Vha26 PE=2 SV=1 PF01991 ATP synthase (E/31 kDa) subunit GO:0015991//GO:0015992//GO:0006119 ATP hydrolysis coupled proton transport//proton transport//oxidative phosphorylation GO:0046961 proton-transporting ATPase activity, rotational mechanism GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1664 Vacuolar H+-ATPase V1 sector, subunit E Cluster-12752.0 BP_3 23.89 2.19 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12758.0 BP_3 3.00 0.48 595 -- -- -- -- -- 768311759 CP010987.1 522 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12759.0 BP_3 9.00 0.37 1472 260814835 XP_002602119.1 1474 1.1e-160 hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae]>gi|229287425|gb|EEN58131.1| hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae] 597569085 KF990036.1 1451 0 Prunus kansuensis chloroplast, complete genome K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 O03064 1474 4.7e-162 ATP synthase subunit beta, chloroplastic (Fragment) OS=Adiantum raddianum GN=atpB PE=3 SV=2 PF00006//PF01637//PF03193//PF00005//PF00910//PF00306//PF02823//PF00004 ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//RNA helicase//ATP synthase alpha/beta chain, C terminal domain//ATP synthase, Delta/Epsilon chain, beta-sandwich domain//ATPase family associated with various cellular activities (AAA) GO:0005975//GO:0015992//GO:0015986//GO:0015991//GO:0006119 carbohydrate metabolic process//proton transport//ATP synthesis coupled proton transport//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0016887//GO:0046961//GO:0008553//GO:0046933//GO:0005524//GO:0016757//GO:0003924//GO:0005525//GO:0003724//GO:0003723//GO:0016820 ATPase activity//proton-transporting ATPase activity, rotational mechanism//hydrogen-exporting ATPase activity, phosphorylative mechanism//proton-transporting ATP synthase activity, rotational mechanism//ATP binding//transferase activity, transferring glycosyl groups//GTPase activity//GTP binding//RNA helicase activity//RNA binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033178//GO:0045259//GO:0045261 proton-transporting two-sector ATPase complex, catalytic domain//proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1350 F0F1-type ATP synthase, beta subunit Cluster-12759.2 BP_3 3.00 0.62 524 260814835 XP_002602119.1 514 8.5e-50 hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae]>gi|229287425|gb|EEN58131.1| hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae] 808178593 KP760075.1 524 0 Prunus subhirtella var. subhirtella isolate 2014-P2 chloroplast, complete genome K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q09X10 844 1.9e-89 ATP synthase subunit beta, chloroplastic OS=Morus indica GN=atpB PE=3 SV=1 PF02874 ATP synthase alpha/beta family, beta-barrel domain GO:0015992//GO:0005975//GO:0015986//GO:0046034//GO:0006119//GO:0015991 proton transport//carbohydrate metabolic process//ATP synthesis coupled proton transport//ATP metabolic process//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046933//GO:0008553//GO:0016757//GO:0005524 proton-transporting ATP synthase activity, rotational mechanism//hydrogen-exporting ATPase activity, phosphorylative mechanism//transferase activity, transferring glycosyl groups//ATP binding GO:0045261//GO:0045259 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex KOG1350 F0F1-type ATP synthase, beta subunit Cluster-1276.0 BP_3 10.00 0.78 908 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12760.0 BP_3 2.00 1.03 383 -- -- -- -- -- 697081608 XM_009655924.1 380 0 Verticillium dahliae VdLs.17 RNA-binding protein rsd1 partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12767.0 BP_3 12.00 0.78 1029 91091192 XP_972192.1 698 7.7e-71 PREDICTED: 23 kDa integral membrane protein [Tribolium castaneum]>gi|270013115|gb|EFA09563.1| hypothetical protein TcasGA2_TC011677 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61451 235 1.5e-18 Leukocyte surface antigen CD53 OS=Mus musculus GN=Cd53 PE=2 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-1278.0 BP_3 5.00 1.16 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12790.0 BP_3 9.43 0.45 1307 270004974 EFA01422.1 156 6.9e-08 odorant receptor 292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016020 membrane -- -- Cluster-12792.0 BP_3 4.00 1.87 393 3287775 P81387.1 306 8.4e-26 RecName: Full=Cuticle protein AMP3; AltName: Full=HA-AMP3 [Homarus americanus] -- -- -- -- -- -- -- -- -- P81577 339 5.2e-31 Cuticle protein AM1199 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-12792.1 BP_3 6.00 0.56 805 5921938 P81578.1 286 3.6e-23 RecName: Full=Cuticle protein AM1239; Short=CPAM1239 [Cancer pagurus] -- -- -- -- -- -- -- -- -- P81578 286 1.5e-24 Cuticle protein AM1239 OS=Cancer pagurus PE=1 SV=1 PF01500//PF00379 Keratin, high sulfur B2 protein//Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle GO:0045095 keratin filament -- -- Cluster-12801.0 BP_3 16.00 1.09 1002 641680650 XP_008189117.1 484 4.9e-46 PREDICTED: probable NADP-dependent mannitol dehydrogenase, partial [Acyrthosiphon pisum] 697075037 XM_009653666.1 792 0 Verticillium dahliae VdLs.17 L-xylulose reductase partial mRNA -- -- -- -- Q8NK50 1149 1.6e-124 NADP-dependent mannitol dehydrogenase OS=Hypocrea jecorina GN=lxr1 PE=1 SV=1 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-12803.0 BP_3 3.00 0.39 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12810.0 BP_3 5.00 0.36 962 767992364 XP_011522247.1 901 2.1e-94 PREDICTED: XIAP-associated factor 1 isoform X1 [Homo sapiens] 378925606 NM_017523.3 927 0 Homo sapiens XIAP associated factor 1 (XAF1), transcript variant 1, mRNA -- -- -- -- Q6GPH4 901 8.6e-96 XIAP-associated factor 1 OS=Homo sapiens GN=XAF1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-12829.0 BP_3 6.00 0.58 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12837.0 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12839.0 BP_3 2.00 1.02 384 321466838 EFX77831.1 257 3.9e-20 hypothetical protein DAPPUDRAFT_305305 [Daphnia pulex] -- -- -- -- -- K02129 ATPeF0E, ATP5I F-type H+-transporting ATPase subunit e http://www.genome.jp/dbget-bin/www_bget?ko:K02129 -- -- -- -- PF05680 ATP synthase E chain GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG4326 Mitochondrial F1F0-ATP synthase, subunit e Cluster-12842.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02096 60Kd inner membrane protein GO:0051205 protein insertion into membrane -- -- GO:0016021 integral component of membrane -- -- Cluster-12845.0 BP_3 6.00 0.41 997 546687063 ERL95973.1 289 2.0e-23 hypothetical protein D910_00717 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12846.0 BP_3 13.00 0.69 1199 -- -- -- -- -- 768311753 CP010981.1 1177 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- O14405 550 5.4e-55 Endoglucanase-4 OS=Hypocrea jecorina GN=cel61a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-12866.1 BP_3 9.00 0.56 1071 553832084 AGY61453.1 1305 3.3e-141 ATP synthase CF1 alpha chain [Lotharella sp. CCMP622] 597569085 KF990036.1 1071 0 Prunus kansuensis chloroplast, complete genome K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 Q2QDA3 1622 2.4e-179 ATP synthase subunit alpha, chloroplastic OS=Cucumis sativus GN=atpA PE=3 SV=1 PF02874//PF00006 ATP synthase alpha/beta family, beta-barrel domain//ATP synthase alpha/beta family, nucleotide-binding domain GO:0046034//GO:0015992 ATP metabolic process//proton transport GO:0005524 ATP binding -- -- KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-12870.0 BP_3 16.00 0.77 1295 472366416 XP_004402747.1 1991 1.1e-220 PREDICTED: 60S ribosomal protein L3 isoform X1 [Odobenus rosmarus divergens] 78395075 BC107711.1 1295 0 Homo sapiens ribosomal protein L3, mRNA (cDNA clone MGC:104284 IMAGE:6699816), complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 P39023 2046 2.0e-228 60S ribosomal protein L3 OS=Homo sapiens GN=RPL3 PE=1 SV=2 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-12885.0 BP_3 25.27 0.48 2852 817072965 XP_012258601.1 180 2.5e-10 PREDICTED: uncharacterized protein LOC105687494 isoform X2 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12890.0 BP_3 2.00 0.71 426 780035922 XP_011667383.1 174 1.8e-10 PREDICTED: autophagy-related protein 9A [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q3T904 143 3.0e-08 Autophagy-related protein 9A OS=Bos taurus GN=ATG9A PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-12894.0 BP_3 5.00 0.53 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12898.0 BP_3 3.00 0.37 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-129.0 BP_3 2.00 0.61 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12906.0 BP_3 6.00 0.49 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12912.0 BP_3 1.00 0.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12914.0 BP_3 5.00 0.40 892 817195055 XP_012273055.1 905 6.6e-95 PREDICTED: splicing factor 3B subunit 1 isoform X1 [Orussus abietinus] -- -- -- -- -- K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O75533 818 3.3e-86 Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0213 Splicing factor 3b, subunit 1 Cluster-12921.0 BP_3 3.00 0.37 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12936.0 BP_3 2.00 0.45 505 262401301 ACY66553.1 499 4.5e-48 ribosomal protein L12 [Scylla paramamosain] 262401300 FJ774832.1 377 0 Scylla paramamosain ribosomal protein L12 mRNA, complete cds K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61284 427 4.1e-41 60S ribosomal protein L12 OS=Bos taurus GN=RPL12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0886 40S ribosomal protein S2 Cluster-12937.0 BP_3 42.53 3.76 837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12938.0 BP_3 3.00 0.39 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12942.0 BP_3 5.00 0.50 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12943.0 BP_3 3.00 0.37 680 724928464 XP_010382736.1 670 9.0e-68 PREDICTED: protein yippee-like 5 [Rhinopithecus roxellana] 672055481 XM_008764510.1 610 0 PREDICTED: Rattus norvegicus yippee-like 5 (Drosophila) (Ypel5), transcript variant X3, mRNA -- -- -- -- Q65Z55 633 7.2e-65 Protein yippee-like 5 OS=Chlorocebus aethiops GN=YPEL5 PE=2 SV=1 PF01641//PF11648//PF00323 SelR domain//C-terminal domain of RIG-I//Mammalian defensin GO:0006952//GO:0055114 defense response//oxidation-reduction process GO:0016817//GO:0033743 hydrolase activity, acting on acid anhydrides//peptide-methionine (R)-S-oxide reductase activity GO:0005576 extracellular region KOG3399 Predicted Yippee-type zinc-binding protein Cluster-12944.0 BP_3 3.00 1.65 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12946.1 BP_3 35.00 1.33 1560 546684937 ERL94519.1 840 4.0e-87 hypothetical protein D910_11796 [Dendroctonus ponderosae] 319433937 HQ881802.1 150 2.88364e-70 Culex pipiens complex sp. YL-2011 isolate UL4_M fork head domain transcription factor slp2 (CPIJ020030) gene, exon 2 and partial cds >gnl|BL_ORD_ID|10103406 Culex pipiens complex sp. YL-2011 isolate RD4_M fork head domain transcription factor slp2 (CPIJ020030) gene, exon 2 and partial cds K09385 FOXG forkhead box protein G http://www.genome.jp/dbget-bin/www_bget?ko:K09385 P32031 495 1.7e-48 Fork head domain transcription factor slp2 OS=Drosophila melanogaster GN=slp2 PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-12947.0 BP_3 48.25 0.54 4569 546677105 ERL88006.1 884 9.3e-92 hypothetical protein D910_05395 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZUX3 313 6.2e-27 Protein FAM179A OS=Homo sapiens GN=FAM179A PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG2933 Uncharacterized conserved protein Cluster-12953.0 BP_3 3.00 0.42 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12955.0 BP_3 6.00 0.55 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12962.0 BP_3 6.00 0.58 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08445 FR47-like protein -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-12965.0 BP_3 6.00 0.49 888 831319423 XP_012692502.1 217 4.0e-15 PREDICTED: transmembrane protein 59 [Clupea harengus] -- -- -- -- -- -- -- -- -- Q3T0Q2 197 3.4e-14 Transmembrane protein 59 OS=Bos taurus GN=TMEM59 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-12968.0 BP_3 9.00 0.89 781 861651512 KMQ97842.1 660 1.5e-66 arrestin-like protein [Lasius niger] -- -- -- -- -- K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P32122 648 1.5e-66 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 PF01899 Na+/H+ ion antiporter subunit GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG3865 Arrestin Cluster-12968.1 BP_3 3.00 0.43 626 66517414 XP_623184.1 440 3.9e-41 PREDICTED: arrestin homolog isoform 2 [Apis mellifera] -- -- -- -- -- K13805 ARR2 arrestin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13805 P32122 431 1.8e-41 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-12972.0 BP_3 4.00 0.73 556 -- -- -- -- -- 697078985 XM_009655017.1 541 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12973.0 BP_3 1.00 1.69 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08040 MNLL subunit GO:0006118 obsolete electron transport GO:0003954 NADH dehydrogenase activity GO:0005739 mitochondrion -- -- Cluster-12986.0 BP_3 4.00 0.66 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12988.0 BP_3 2.00 0.31 598 470416617 XP_004336903.1 218 2.0e-15 acyl carrier protein [Acanthamoeba castellanii str. Neff]>gi|440793713|gb|ELR14890.1| acyl carrier protein [Acanthamoeba castellanii str. Neff] 697087803 XM_009658518.1 405 0 Verticillium dahliae VdLs.17 acyl carrier protein partial mRNA K03955 NDUFAB1 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03955 P11943 387 2.1e-36 Acyl carrier protein, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=nuo-12 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-12991.0 BP_3 1.00 1.35 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12992.0 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12998.0 BP_3 2.00 0.60 452 -- -- -- -- -- 768311759 CP010987.1 405 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12998.1 BP_3 4.00 0.37 808 -- -- -- -- -- 768311759 CP010987.1 805 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- PF00301//PF08465 Rubredoxin//Thymidine kinase from Herpesvirus C-terminal GO:0006230//GO:0006206 TMP biosynthetic process//pyrimidine nucleobase metabolic process GO:0004797//GO:0005524//GO:0005506 thymidine kinase activity//ATP binding//iron ion binding -- -- -- -- Cluster-13.0 BP_3 19.00 2.10 728 91084725 XP_970320.1 262 2.0e-20 PREDICTED: leucine-rich repeat extensin-like protein 5 [Tribolium castaneum]>gi|270008936|gb|EFA05384.1| hypothetical protein TcasGA2_TC015556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-130.0 BP_3 12.00 0.70 1114 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12814//PF01125 Meiotic cell cortex C-terminal pleckstrin homology//G10 protein GO:0032065 cortical protein anchoring GO:0005515//GO:0005543 protein binding//phospholipid binding GO:0005634//GO:0005938 nucleus//cell cortex -- -- Cluster-13031.0 BP_3 9.00 2.35 476 803205511 XP_011963416.1 231 5.0e-17 PREDICTED: zinc finger protein 665-like isoform X3 [Ovis aries] -- -- -- -- -- K10513 ZBTB41 zinc finger and BTB domain-containing protein 41 http://www.genome.jp/dbget-bin/www_bget?ko:K10513 Q6ZNA1 208 9.6e-16 Zinc finger protein 836 OS=Homo sapiens GN=ZNF836 PE=2 SV=2 PF00096//PF13465//PF01844//PF06467//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//HNH endonuclease//MYM-type Zinc finger with FCS sequence motif//C2H2-type zinc finger -- -- GO:0003676//GO:0004519//GO:0008270//GO:0046872 nucleic acid binding//endonuclease activity//zinc ion binding//metal ion binding -- -- -- -- Cluster-13046.0 BP_3 3.00 0.33 732 -- -- -- -- -- 768311759 CP010987.1 693 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13047.0 BP_3 5.00 0.34 993 694532554 XP_009494490.1 982 8.7e-104 cystathionine gamma-lyase [Fonticula alba]>gi|627949503|gb|KCV71367.1| cystathionine gamma-lyase [Fonticula alba] 768311757 CP010985.1 972 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 P31373 1073 1.0e-115 Cystathionine gamma-lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYS3 PE=1 SV=2 PF01053//PF01212//PF00155//PF01118 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II//Semialdehyde dehydrogenase, NAD binding domain GO:0006520//GO:0009058//GO:0055114 cellular amino acid metabolic process//biosynthetic process//oxidation-reduction process GO:0016829//GO:0016620//GO:0030170//GO:0051287 lyase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//pyridoxal phosphate binding//NAD binding -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-13047.1 BP_3 8.00 0.91 715 24266981 AAN52387.1 623 2.7e-62 ribosomal protein S13 [Branchiostoma belcheri] 697084485 XM_009656927.1 706 0 Verticillium dahliae VdLs.17 40S ribosomal protein S13 mRNA K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 P33192 647 1.8e-66 40S ribosomal protein S13 OS=Candida maltosa GN=RPS13 PE=3 SV=2 PF00312//PF08069//PF00292 Ribosomal protein S15//Ribosomal S13/S15 N-terminal domain//'Paired box' domain GO:0042254//GO:0006412//GO:0006355 ribosome biogenesis//translation//regulation of transcription, DNA-templated GO:0003735//GO:0003677 structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG0400 40S ribosomal protein S13 Cluster-13057.0 BP_3 3.13 0.50 595 478250463 ENN70958.1 414 3.8e-38 hypothetical protein YQE_12359, partial [Dendroctonus ponderosae] -- -- -- -- -- K05313 GRIN glutamate receptor, ionotropic, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13059.0 BP_3 3.00 0.35 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13067.0 BP_3 4.00 0.50 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1307.0 BP_3 6.00 0.52 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02537 CrcB-like protein, Camphor Resistance (CrcB) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-1307.1 BP_3 5.00 0.53 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13077.0 BP_3 10.00 0.41 1481 780104289 XP_011675658.1 243 6.4e-18 PREDICTED: zinc finger protein OZF isoform X6 [Strongylocentrotus purpuratus]>gi|780104294|ref|XP_011675659.1| PREDICTED: zinc finger protein OZF isoform X6 [Strongylocentrotus purpuratus] 236460447 NM_001300.5 1478 0 Homo sapiens Kruppel-like factor 6 (KLF6), transcript variant A, mRNA K09207 KLF6_7 krueppel-like factor 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K09207 Q99612 1196 8.2e-130 Krueppel-like factor 6 OS=Homo sapiens GN=KLF6 PE=1 SV=3 PF13465//PF00096//PF07535 Zinc-finger double domain//Zinc finger, C2H2 type//DBF zinc finger -- -- GO:0046872//GO:0008270//GO:0003676 metal ion binding//zinc ion binding//nucleic acid binding -- -- KOG1721 FOG: Zn-finger Cluster-13086.0 BP_3 13.00 0.44 1716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13087.0 BP_3 5.00 0.35 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13088.0 BP_3 4.00 0.62 604 -- -- -- -- -- 768311756 CP010984.1 604 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- B0XVI5 310 1.8e-27 1,3-beta-glucanosyltransferase gel4 OS=Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) GN=gel4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-131.0 BP_3 11.00 1.37 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13106.0 BP_3 6.00 1.70 462 -- -- -- -- -- 768311753 CP010981.1 456 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13108.0 BP_3 6.00 0.61 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1311.0 BP_3 2.00 3.23 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13118.0 BP_3 2.00 0.36 557 -- -- -- -- -- 768311753 CP010981.1 557 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13121.0 BP_3 21.00 2.93 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13123.0 BP_3 4.00 0.52 666 443614327 AGC96525.1 540 1.0e-52 thioredoxin 1 [Scylla paramamosain] 443614326 JQ864188.1 645 0 Scylla paramamosain clone PXQ014G02 thioredoxin 1 mRNA, complete cds K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q6XHI1 331 7.4e-30 Thioredoxin-2 OS=Drosophila yakuba GN=Trx-2 PE=3 SV=1 PF08534//PF00085//PF00578//PF02966 Redoxin//Thioredoxin//AhpC/TSA family//Mitosis protein DIM1 GO:0055114//GO:0045454//GO:0000398 oxidation-reduction process//cell redox homeostasis//mRNA splicing, via spliceosome GO:0016491//GO:0016209 oxidoreductase activity//antioxidant activity GO:0005681 spliceosomal complex KOG0907 Thioredoxin Cluster-13128.0 BP_3 8.00 0.37 1335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13129.0 BP_3 3.00 0.36 688 156351451 XP_001622517.1 140 2.6e-06 predicted protein [Nematostella vectensis]>gi|156209076|gb|EDO30417.1| predicted protein, partial [Nematostella vectensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13137.1 BP_3 6.00 0.67 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13148.0 BP_3 11.00 1.29 702 734546692 KHN75153.1 701 2.4e-71 60S ribosomal protein L11 [Toxocara canis] 697090412 XM_009659817.1 699 0 Verticillium dahliae VdLs.17 60S ribosomal protein L11 mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 Q7RVN0 773 4.3e-81 60S ribosomal protein L11 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-11 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-13149.0 BP_3 2.00 0.48 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13161.0 BP_3 17.00 0.61 1643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-13177.0 BP_3 5.00 0.91 557 -- -- -- -- -- 525346445 KC793917.1 86 3.73863e-35 Scylla paramamosain clone Scpa25 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13179.0 BP_3 13.00 0.55 1437 288779616 BAI70369.1 445 2.3e-41 eukaryotic initiation factor 4E binding protein [Marsupenaeus japonicus] -- -- -- -- -- K07205 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07205 Q60876 268 3.2e-22 Eukaryotic translation initiation factor 4E-binding protein 1 OS=Mus musculus GN=Eif4ebp1 PE=1 SV=3 PF05456 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) GO:0045947 negative regulation of translational initiation GO:0008190 eukaryotic initiation factor 4E binding -- -- -- -- Cluster-13181.0 BP_3 1.00 0.36 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13184.0 BP_3 9.00 0.54 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-132.0 BP_3 2.00 0.51 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13206.0 BP_3 17.00 0.44 2151 577297 BAA07643.1 1200 9.9e-129 KIAA0085 [Homo sapiens] 222418609 NM_006762.2 2148 0 Homo sapiens lysosomal protein transmembrane 5 (LAPTM5), mRNA K12387 LAPTM lysosomal-associated transmembrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K12387 Q13571 1167 2.7e-126 Lysosomal-associated transmembrane protein 5 OS=Homo sapiens GN=LAPTM5 PE=1 SV=1 PF03821 Golgi 4-transmembrane spanning transporter -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-13213.0 BP_3 2.00 0.97 389 754345551 XP_011270172.1 452 9.7e-43 hypothetical protein CAOG_08572, partial [Capsaspora owczarzaki ATCC 30864] 768311756 CP010984.1 389 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 P50142 570 8.3e-58 Heat shock protein 60, mitochondrial OS=Ajellomyces capsulatus GN=HSP60 PE=3 SV=2 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-13218.0 BP_3 8.00 1.15 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13219.0 BP_3 8.00 0.33 1475 817214031 XP_012283269.1 677 3.0e-68 PREDICTED: myophilin [Orussus abietinus] -- -- -- -- -- -- -- -- -- P14318 442 2.2e-42 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF05706//PF00307 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Calponin homology (CH) domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515//GO:0004721 protein tyrosine phosphatase activity//protein binding//phosphoprotein phosphatase activity -- -- KOG2046 Calponin Cluster-13223.0 BP_3 1.00 13.75 235 386837 AAA36128.1 310 1.7e-26 15-kDa protein, partial [Homo sapiens] 38114701 BC009507.2 235 2.15445e-118 Homo sapiens ISG15 ubiquitin-like modifier, mRNA (cDNA clone MGC:3945 IMAGE:3545944), complete cds K12159 ISG15 ubiquitin cross-reactive protein http://www.genome.jp/dbget-bin/www_bget?ko:K12159 P05161 310 7.1e-28 Ubiquitin-like protein ISG15 OS=Homo sapiens GN=ISG15 PE=1 SV=5 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-13224.1 BP_3 14.00 2.95 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13227.1 BP_3 2.00 0.40 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13236.0 BP_3 3.00 0.59 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13237.0 BP_3 2.00 0.44 510 -- -- -- -- -- 767943536 XM_011536110.1 510 0 PREDICTED: Homo sapiens ezrin (EZR), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13243.0 BP_3 6.00 0.31 1231 262401390 ACY66597.1 211 2.7e-14 hypothetical protein [Scylla paramamosain] 262401389 FJ774877.1 270 4.43373e-137 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13243.1 BP_3 3.00 1.09 424 17549915 NP_509585.1 319 2.8e-27 TBB-4 [Caenorhabditis elegans]>gi|268576989|ref|XP_002643476.1| C. briggsae CBR-TBB-4 protein [Caenorhabditis briggsae]>gi|1174596|sp|P41937.1|TBB4_CAEEL RecName: Full=Tubulin beta-4 chain; AltName: Full=Beta-4-tubulin [Caenorhabditis elegans]>gi|3873688|emb|CAA86310.1| TBB-4 [Caenorhabditis elegans] 333411319 JF767013.1 163 4.38995e-78 Helicoverpa armigera beta-tubulin mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 319 1.2e-28 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 -- -- GO:0051258//GO:0007018//GO:0006184//GO:0007067//GO:0009792 protein polymerization//microtubule-based movement//obsolete GTP catabolic process//mitotic nuclear division//embryo development ending in birth or egg hatching GO:0003924//GO:0005198//GO:0005525 GTPase activity//structural molecule activity//GTP binding GO:0005737//GO:0005879 cytoplasm//axonemal microtubule KOG1375 Beta tubulin Cluster-13247.0 BP_3 2.00 1.08 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13247.1 BP_3 7.00 0.82 701 751453875 XP_011181382.1 232 5.7e-17 PREDICTED: adult-specific rigid cuticular protein 15.5-like [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- P82119 179 3.3e-12 Cuticle protein 6 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-1325.0 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13256.0 BP_3 17.00 0.65 1558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1326.0 BP_3 3.00 0.78 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13268.0 BP_3 2.00 0.46 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1327.0 BP_3 3.00 0.74 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13271.0 BP_3 5.00 0.36 958 569366696 ETO09895.1 184 2.9e-11 ZIP transporter [Reticulomyxa filosa] -- -- -- -- -- -- -- -- -- Q12436 193 1.1e-13 Zinc-regulated transporter 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZRT2 PE=1 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-1328.0 BP_3 1.00 0.82 345 871218664 XP_012935438.1 252 1.3e-19 PREDICTED: calponin-1-like [Aplysia californica] -- -- -- -- -- -- -- -- -- P26932 213 1.8e-16 Calponin-1 OS=Gallus gallus GN=CNN1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-13286.0 BP_3 2.00 0.40 532 321458779 EFX69841.1 655 3.9e-66 hypothetical protein DAPPUDRAFT_300660 [Daphnia pulex] -- -- -- -- -- K00826 E2.6.1.42, ilvE branched-chain amino acid aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00826 A7SLW1 625 4.8e-64 Branched-chain-amino-acid aminotransferase OS=Nematostella vectensis GN=v1g246094 PE=3 SV=1 PF01063 Amino-transferase class IV GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0975 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily Cluster-13294.0 BP_3 2.00 0.71 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13295.0 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-133.0 BP_3 4.00 0.34 861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13308.0 BP_3 4.00 0.38 794 333466057 AEF33797.1 1042 7.7e-111 Rab7 [Fenneropenaeus chinensis] 167466098 AB379643.1 307 7.6173e-158 Marsupenaeus japonicus Rab7 mRNA for WSDV receptor Rab7, complete cds K07897 RAB7A Ras-related protein Rab-7A http://www.genome.jp/dbget-bin/www_bget?ko:K07897 P18067 922 2.6e-98 Ras-related protein Rab-7a OS=Canis familiaris GN=RAB7A PE=2 SV=1 PF00025//PF07728//PF00735//PF08477//PF01926//PF00485//PF00503//PF04670//PF00910//PF10662//PF00071//PF00005//PF03266//PF03193//PF01637 ADP-ribosylation factor family//AAA domain (dynein-related subfamily)//Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Phosphoribulokinase / Uridine kinase family//G-protein alpha subunit//Gtr1/RagA G protein conserved region//RNA helicase//Ethanolamine utilisation - propanediol utilisation//Ras family//ABC transporter//NTPase//Protein of unknown function, DUF258//Archaeal ATPase GO:0007264//GO:0008152//GO:0006576//GO:0007186//GO:0007165 small GTPase mediated signal transduction//metabolic process//cellular biogenic amine metabolic process//G-protein coupled receptor signaling pathway//signal transduction GO:0004871//GO:0005525//GO:0003724//GO:0003723//GO:0016887//GO:0019001//GO:0016301//GO:0098519//GO:0031683//GO:0005524//GO:0003924 signal transducer activity//GTP binding//RNA helicase activity//RNA binding//ATPase activity//guanyl nucleotide binding//kinase activity//nucleotide phosphatase activity, acting on free nucleotides//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity -- -- KOG0394 Ras-related GTPase Cluster-13309.0 BP_3 5.00 0.49 787 270007970 EFA04418.1 150 2.1e-07 hypothetical protein TcasGA2_TC014718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00797 N-acetyltransferase GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0016407 acetyltransferase activity -- -- -- -- Cluster-13311.0 BP_3 5.00 37.66 251 241781184 XP_002400257.1 246 4.8e-19 ribosomal protein L39, putative [Ixodes scapularis]>gi|215510701|gb|EEC20154.1| ribosomal protein L39, putative [Ixodes scapularis] 225708741 BT075793.1 55 2.66446e-18 Caligus rogercresseyi clone crog-evm-507-292 60S ribosomal protein L39 putative mRNA, complete cds K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 Q6F482 225 5.4e-18 60S ribosomal protein L39 OS=Plutella xylostella GN=RpL39 PE=3 SV=1 PF00832 Ribosomal L39 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0002 60s ribosomal protein L39 Cluster-13316.0 BP_3 13.00 0.75 1129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13316.1 BP_3 14.00 0.97 989 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13318.0 BP_3 7.00 1.13 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13323.0 BP_3 9.44 0.37 1528 766918539 XP_011498898.1 703 3.0e-71 PREDICTED: heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [Ceratosolen solmsi marchali] -- -- -- -- -- K13158 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 http://www.genome.jp/dbget-bin/www_bget?ko:K13158 P21522 682 3.4e-70 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF04828//PF16367//PF00076//PF03972//PF08777 Glutathione-dependent formaldehyde-activating enzyme//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//MmgE/PrpD family//RNA binding motif GO:0008152 metabolic process GO:0016829//GO:0003723//GO:0016846//GO:0003676 lyase activity//RNA binding//carbon-sulfur lyase activity//nucleic acid binding -- -- -- -- Cluster-13333.0 BP_3 2.00 0.95 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04604 Type-A lantibiotic GO:0042742 defense response to bacterium -- -- GO:0005576 extracellular region -- -- Cluster-13339.0 BP_3 2.00 1.54 349 449273737 EMC83151.1 174 1.5e-10 Enterin neuropeptide, partial [Columba livia] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13341.0 BP_3 4.00 0.31 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13346.0 BP_3 3.00 1.63 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13359.0 BP_3 3.00 0.43 626 470323323 XP_004349466.1 259 3.8e-20 receptor accessory protein 5 [Capsaspora owczarzaki ATCC 30864]>gi|765550978|gb|KJE91599.1| receptor accessory protein 5 [Capsaspora owczarzaki ATCC 30864] 697066784 XM_009650284.1 510 0 Verticillium dahliae VdLs.17 yop-1 partial mRNA K17279 REEP5_6 receptor expression-enhancing protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K17279 Q871R7 547 6.2e-55 Protein yop-1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=yop-1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-13362.0 BP_3 3.00 1.26 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13367.0 BP_3 1.00 0.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13378.0 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13382.0 BP_3 7.41 0.34 1327 546674815 ERL86101.1 908 4.4e-95 hypothetical protein D910_03515 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0UYT5 156 2.9e-09 Major facilitator superfamily domain-containing protein 6-B OS=Danio rerio GN=mfsd6b PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-13402.0 BP_3 6.00 0.88 622 167519404 XP_001744042.1 385 9.2e-35 hypothetical protein [Monosiga brevicollis MX1]>gi|163778004|gb|EDQ91620.1| predicted protein [Monosiga brevicollis MX1] 768311755 CP010983.1 420 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence K02915 RP-L34e, RPL34 large subunit ribosomal protein L34e http://www.genome.jp/dbget-bin/www_bget?ko:K02915 P40525 425 8.7e-41 60S ribosomal protein L34-B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL34B PE=1 SV=1 PF01199//PF11575 Ribosomal protein L34e//FhuF 2Fe-2S C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0051537//GO:0003735 2 iron, 2 sulfur cluster binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1790 60s ribosomal protein L34 Cluster-13411.1 BP_3 8.00 0.43 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13412.0 BP_3 3.00 0.68 505 452187308 AGG09867.1 538 1.4e-52 mitochondrial ketol-acid reductoisomerase precursor, partial [Nilaparvata lugens] 768311753 CP010981.1 505 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- P38674 791 2.6e-83 Ketol-acid reductoisomerase, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=ilv-2 PE=3 SV=2 PF01450 Acetohydroxy acid isomeroreductase, catalytic domain GO:0009097//GO:0009098//GO:0015940//GO:0055114//GO:0009099//GO:0009082 isoleucine biosynthetic process//leucine biosynthetic process//pantothenate biosynthetic process//oxidation-reduction process//valine biosynthetic process//branched-chain amino acid biosynthetic process GO:0004455 ketol-acid reductoisomerase activity -- -- -- -- Cluster-13419.0 BP_3 2.00 0.45 505 194324935 ACF49124.1 297 1.2e-24 FK506-binding protein-like protein [Echinococcus granulosus]>gi|576696367|gb|EUB59922.1| Peptidyl-prolyl cis-trans isomerase FKBP1A [Echinococcus granulosus] 697069822 XM_009651800.1 468 0 Verticillium dahliae VdLs.17 FK506-binding protein partial mRNA K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 Q6M981 448 1.5e-43 FK506-binding protein 1B OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=fkr-3 PE=3 SV=2 PF00254//PF00832 FKBP-type peptidyl-prolyl cis-trans isomerase//Ribosomal L39 protein GO:0042254//GO:0006412//GO:0006457 ribosome biogenesis//translation//protein folding GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-13426.0 BP_3 4.00 0.57 632 159145772 ABW90423.1 431 4.3e-40 putative ribosomal protein S17 [Barentsia elongata] 697090196 XM_009659709.1 618 0 Verticillium dahliae VdLs.17 40S ribosomal protein S17 mRNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 P27770 651 5.5e-67 40S ribosomal protein S17 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-17 PE=3 SV=1 PF00833 Ribosomal S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0187 40S ribosomal protein S17 Cluster-13428.0 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13429.0 BP_3 4.00 0.68 574 675870274 XP_009020697.1 194 1.2e-12 hypothetical protein HELRODRAFT_93038, partial [Helobdella robusta]>gi|555697972|gb|ESO01205.1| hypothetical protein HELRODRAFT_93038, partial [Helobdella robusta] 697069332 XM_009651555.1 574 0 Verticillium dahliae VdLs.17 60S ribosomal protein L22 mRNA K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q09668 266 2.2e-22 60S ribosomal protein L22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl22 PE=1 SV=3 PF01776//PF01852 Ribosomal L22e protein family//START domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008289//GO:0003735 lipid binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3434 60S ribosomal protein L22 Cluster-13430.0 BP_3 4.00 0.56 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13435.1 BP_3 1.00 0.60 369 91077926 XP_974115.1 405 2.6e-37 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P50163 178 2.2e-12 Tropinone reductase 2 OS=Datura stramonium GN=TR2 PE=1 SV=1 PF00106 short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0000166 oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-13441.0 BP_3 3.00 0.38 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13450.0 BP_3 6.00 0.35 1122 766932923 XP_011498704.1 738 1.9e-75 PREDICTED: MFS-type transporter SLC18B1-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- Q6NT16 393 8.0e-37 MFS-type transporter SLC18B1 OS=Homo sapiens GN=SLC18B1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG3764 Vesicular amine transporter Cluster-13453.0 BP_3 6.00 0.49 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13459.1 BP_3 15.00 0.39 2124 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13461.1 BP_3 1.00 0.37 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13464.0 BP_3 1.00 0.43 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13474.0 BP_3 6.00 0.74 682 411595986 AFW19996.1 600 1.2e-59 mitochondrial cytochrome c oxidase subunit Va [Litopenaeus vannamei] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 415 1.4e-39 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284 Cytochrome c oxidase subunit Va GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-13475.0 BP_3 4.00 0.66 586 -- -- -- -- -- 768311755 CP010983.1 554 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13477.0 BP_3 40.00 0.36 5583 270013025 EFA09473.1 4944 0.0e+00 hypothetical protein TcasGA2_TC010967 [Tribolium castaneum] 642934190 XM_008201424.1 517 0 PREDICTED: Tribolium castaneum uncharacterized LOC657839 (LOC657839), transcript variant X3, mRNA K05213 GRIN3A glutamate receptor ionotropic, NMDA 3A http://www.genome.jp/dbget-bin/www_bget?ko:K05213 Q8TCU5 664 1.5e-67 Glutamate receptor ionotropic, NMDA 3A OS=Homo sapiens GN=GRIN3A PE=1 SV=2 PF07271//PF00060//PF10613 Cytadhesin P30/P32//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007268//GO:0007165//GO:0009405//GO:0007157//GO:0006811 synaptic transmission//signal transduction//pathogenesis//heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules//ion transport GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-13481.0 BP_3 3.68 3.91 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13484.0 BP_3 1.00 1.80 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13491.0 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13493.0 BP_3 4.00 0.47 701 222160395 ACM47362.1 222 8.2e-16 Sox14 protein [Scylla paramamosain] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13494.0 BP_3 2.00 0.37 553 -- -- -- -- -- 768311752 CP010980.1 547 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13496.0 BP_3 16.00 0.79 1273 410912342 XP_003969649.1 655 9.2e-66 PREDICTED: 60S ribosomal protein L12 [Takifugu rubripes] 697076517 XM_009654164.1 821 0 Verticillium dahliae VdLs.17 60S ribosomal protein L12 mRNA K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 Q9C285 752 2.1e-78 60S ribosomal protein L12 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-12 PE=3 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-13497.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13498.0 BP_3 4.00 0.40 774 551510201 XP_005806623.1 276 5.0e-22 PREDICTED: ras-related protein Rab-1A-like isoform X1 [Xiphophorus maculatus] 768311756 CP010984.1 716 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence K07875 RAB1B Ras-related protein Rab-1B http://www.genome.jp/dbget-bin/www_bget?ko:K07875 P33723 343 3.5e-31 GTP-binding protein ypt1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=ypt-1 PE=3 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-135.0 BP_3 1.00 0.59 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13500.0 BP_3 2.00 0.45 505 260804857 XP_002597304.1 508 4.0e-49 hypothetical protein BRAFLDRAFT_203247 [Branchiostoma floridae]>gi|229282567|gb|EEN53316.1| hypothetical protein BRAFLDRAFT_203247 [Branchiostoma floridae] 148230960 NM_001094813.1 92 1.55922e-38 Xenopus laevis TSR1, 20S rRNA accumulation, homolog (tsr1), mRNA >gnl|BL_ORD_ID|630648 Xenopus laevis hypothetical LOC495115, mRNA (cDNA clone MGC:83112 IMAGE:6317840), complete cds K14799 TSR1 pre-rRNA-processing protein TSR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14799 Q5XGY1 493 9.1e-49 Pre-rRNA-processing protein TSR1 homolog OS=Xenopus laevis GN=tsr1 PE=2 SV=1 -- -- GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1980 Uncharacterized conserved protein Cluster-13501.0 BP_3 1.00 0.38 418 -- -- -- -- -- 697086829 XM_009658032.1 418 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13503.0 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13507.0 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13512.0 BP_3 6.00 0.55 819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13515.1 BP_3 2.00 0.41 525 -- -- -- -- -- 332640072 CP002686.1 522 0 Arabidopsis thaliana chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13519.1 BP_3 10.00 0.33 1753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13522.0 BP_3 4.00 0.87 513 871208251 XP_005090180.2 195 8.1e-13 PREDICTED: protein SFI1 homolog [Aplysia californica]>gi|871208254|ref|XP_012939858.1| PREDICTED: protein SFI1 homolog [Aplysia californica] -- -- -- -- -- K16489 SFI1 protein SFI1 http://www.genome.jp/dbget-bin/www_bget?ko:K16489 A9CB34 166 7.7e-11 Protein SFI1 homolog OS=Papio anubis GN=SFI1 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-13523.0 BP_3 18.00 1.40 913 270004918 EFA01366.1 450 3.9e-42 hypothetical protein TcasGA2_TC010351 [Tribolium castaneum] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 Q17005 276 2.4e-23 Lysozyme c-1 OS=Anopheles gambiae GN=AGAP007347 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-13526.0 BP_3 2.00 0.39 542 321476934 EFX87893.1 434 1.7e-40 hypothetical protein DAPPUDRAFT_42690 [Daphnia pulex] -- -- -- -- -- K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 Q9JMA9 380 1.2e-35 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) OS=Mus musculus GN=Slc6a14 PE=2 SV=1 PF15836//PF00209 SSTK-interacting protein, TSSK6-activating co-chaperone protein//Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0051087//GO:0005328 chaperone binding//neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-13536.1 BP_3 2.00 2.75 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13548.0 BP_3 1.00 0.55 377 338224500 AEI88123.1 570 2.0e-56 hypothetical protein [Scylla paramamosain] 338224499 HM217901.1 305 4.46145e-157 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF03067 Chitin binding domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-13552.0 BP_3 20.00 8.56 403 241564915 XP_002401963.1 339 1.3e-29 ribosomal protein S25, putative [Ixodes scapularis]>gi|215501939|gb|EEC11433.1| ribosomal protein S25, putative, partial [Ixodes scapularis] 262401431 FJ774898.1 190 4.06694e-93 Scylla paramamosain 40S ribosomal protein S25 mRNA, partial cds K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q962Q5 315 3.2e-28 40S ribosomal protein S25 OS=Spodoptera frugiperda GN=RpS25 PE=3 SV=1 PF01325//PF08220 Iron dependent repressor, N-terminal DNA binding domain//DeoR-like helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005622//GO:0005840 transcription factor complex//intracellular//ribosome KOG1767 40S ribosomal protein S25 Cluster-13560.0 BP_3 2.49 0.49 537 321475910 EFX86871.1 368 7.4e-33 hypothetical protein DAPPUDRAFT_43800 [Daphnia pulex] -- -- -- -- -- K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 O55164 338 9.2e-31 Multiple PDZ domain protein OS=Rattus norvegicus GN=Mpdz PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-13566.0 BP_3 4.00 0.38 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13572.0 BP_3 2.00 1.26 365 861617429 KMQ86582.1 273 5.2e-22 gag-pol polyprotein [Lasius niger] 404312713 AC253540.1 347 1.93368e-180 Prunus persica clone JGIBIXB-13K9, complete sequence -- -- -- -- P10978 229 2.7e-18 Retrovirus-related Pol polyprotein from transposon TNT 1-94 OS=Nicotiana tabacum PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-13574.0 BP_3 12.00 0.53 1389 91082391 XP_969041.1 1141 4.5e-122 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|642922554|ref|XP_008193224.1| PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270007505|gb|EFA03953.1| hypothetical protein TcasGA2_TC014097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 492 3.3e-48 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-13580.0 BP_3 28.00 1.15 1468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1359.0 BP_3 6.00 0.55 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13592.0 BP_3 3.00 0.69 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13593.2 BP_3 35.04 1.00 1984 642911122 XP_008200589.1 2412 2.6e-269 PREDICTED: endoplasmic reticulum aminopeptidase 1-like isoform X4 [Tribolium castaneum] 462310582 APGK01047275.1 78 3.89997e-30 Dendroctonus ponderosae Seq01047285, whole genome shotgun sequence K11141 ENPEP glutamyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11141 Q10836 931 5.9e-99 Thyrotropin-releasing hormone-degrading ectoenzyme OS=Rattus norvegicus GN=Trhde PE=1 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-13597.0 BP_3 3.00 0.36 688 270003164 EEZ99611.1 486 2.0e-46 hypothetical protein TcasGA2_TC002128 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16782 Nucleotide exchange factor SIL1 -- -- GO:0000774 adenyl-nucleotide exchange factor activity GO:0005783 endoplasmic reticulum -- -- Cluster-13598.0 BP_3 3.00 0.41 643 828192553 XP_012560502.1 179 7.3e-11 PREDICTED: uncharacterized protein LOC105846369 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09446//PF08082//PF01057 VMA21-like domain//PRO8NT (NUC069), PrP8 N-terminal domain//Parvovirus non-structural protein NS1 GO:0000398//GO:0019079//GO:0070072 mRNA splicing, via spliceosome//viral genome replication//vacuolar proton-transporting V-type ATPase complex assembly -- -- -- -- -- -- Cluster-136.0 BP_3 5.00 1.58 444 560119268 CDJ96098.1 160 8.0e-09 Transposase domain containing protein [Haemonchus contortus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13602.0 BP_3 3.00 0.40 650 -- -- -- -- -- 768311754 CP010982.1 546 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13606.0 BP_3 2.00 0.31 605 270005432 EFA01880.1 463 8.0e-44 hypothetical protein TcasGA2_TC007485 [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P23677 391 7.4e-37 Inositol-trisphosphate 3-kinase A OS=Homo sapiens GN=ITPKA PE=1 SV=1 PF03770//PF01299 Inositol polyphosphate kinase//Lysosome-associated membrane glycoprotein (Lamp) -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity GO:0016020 membrane KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-13609.0 BP_3 6.00 1.76 456 857978576 CEO95459.1 202 1.1e-13 hypothetical protein PBRA_004185 [Plasmodiophora brassicae] 697085153 XM_009657195.1 367 0 Verticillium dahliae VdLs.17 nucleosome binding protein mRNA K11296 HMGB3 high mobility group protein B3 http://www.genome.jp/dbget-bin/www_bget?ko:K11296 P11632 261 6.6e-22 Non-histone chromosomal protein 6A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NHP6A PE=1 SV=1 PF08073 CHDNT (NUC034) domain GO:0006355 regulation of transcription, DNA-templated GO:0016818//GO:0005524//GO:0008270//GO:0003677 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//zinc ion binding//DNA binding GO:0005634 nucleus KOG0381 HMG box-containing protein Cluster-1361.0 BP_3 1.00 5.73 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13616.0 BP_3 2.00 0.33 583 321475463 EFX86426.1 213 7.6e-15 hypothetical protein DAPPUDRAFT_313136 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q9UPN3 147 1.4e-08 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens GN=MACF1 PE=1 SV=4 PF00435 Spectrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-13627.0 BP_3 3.17 0.33 752 478259689 ENN79533.1 316 1.1e-26 hypothetical protein YQE_03996, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-1363.0 BP_3 2.48 0.31 682 170027856 XP_001841813.1 245 1.7e-18 g-protein coupled receptor [Culex quinquefasciatus]>gi|167862383|gb|EDS25766.1| g-protein coupled receptor [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13641.0 BP_3 2.00 0.59 454 -- -- -- -- -- 768311753 CP010981.1 451 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13646.0 BP_3 4.00 0.35 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13651.0 BP_3 2.00 0.60 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13654.0 BP_3 3.00 1.66 376 91082087 XP_966991.1 261 1.3e-20 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270007417|gb|EFA03865.1| hypothetical protein TcasGA2_TC013987 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 222 1.8e-17 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-13655.0 BP_3 11.17 0.85 928 -- -- -- -- -- 404312705 AC253545.1 862 0 Prunus persica clone JGIBIXB-13E11, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13661.1 BP_3 2.00 1.42 355 514699137 XP_004997137.1 362 2.4e-32 fumarylacetoacetase [Salpingoeca rosetta]>gi|326435006|gb|EGD80576.1| fumarylacetoacetase [Salpingoeca rosetta] -- -- -- -- -- K01555 FAH, fahA fumarylacetoacetase http://www.genome.jp/dbget-bin/www_bget?ko:K01555 A5PKH3 331 3.9e-30 Fumarylacetoacetase OS=Bos taurus GN=FAH PE=2 SV=1 PF09298 Fumarylacetoacetase N-terminal GO:0009072//GO:0006570//GO:0042207 aromatic amino acid family metabolic process//tyrosine metabolic process//styrene catabolic process GO:0004334 fumarylacetoacetase activity -- -- KOG2843 Fumarylacetoacetase Cluster-13662.0 BP_3 7.23 0.35 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13673.0 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13674.0 BP_3 4.00 0.43 742 189236750 XP_975130.2 717 3.5e-73 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 197 2.8e-14 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-1368.0 BP_3 2.00 0.45 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00614 Phospholipase D Active site motif -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-13684.0 BP_3 1.00 0.72 354 -- -- -- -- -- 768311758 CP010986.1 342 1.12522e-177 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13685.1 BP_3 3.00 0.36 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04258 Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-13700.0 BP_3 2.00 0.52 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13709.0 BP_3 3.00 0.35 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13711.0 BP_3 1.00 0.52 383 -- -- -- -- -- 768311759 CP010987.1 380 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13714.0 BP_3 2.00 0.69 431 167538127 XP_001750729.1 201 1.4e-13 hypothetical protein [Monosiga brevicollis MX1]>gi|163770753|gb|EDQ84434.1| predicted protein [Monosiga brevicollis MX1] 697089396 XM_009659312.1 409 0 Verticillium dahliae VdLs.17 60S ribosomal protein L29 mRNA K02905 RP-L29e, RPL29 large subunit ribosomal protein L29e http://www.genome.jp/dbget-bin/www_bget?ko:K02905 P05747 250 1.2e-20 60S ribosomal protein L29 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL29 PE=1 SV=3 PF01779 Ribosomal L29e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3504 60S ribosomal protein L29 Cluster-13717.1 BP_3 4.00 0.71 562 255045899 ACU00106.1 714 5.9e-73 troponin-C isoform 6 [Homarus americanus] 298106305 HM448422.1 51 1.07954e-15 Homarus americanus troponin C isoform 3 mRNA, complete cds -- -- -- -- P15159 429 2.7e-41 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF00036//PF13833//PF13405//PF13499//PF03352//PF13202//PF12763 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Methyladenine glycosylase//EF hand//Cytoskeletal-regulatory complex EF hand GO:0006284 base-excision repair GO:0005509//GO:0008725//GO:0005515 calcium ion binding//DNA-3-methyladenine glycosylase activity//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-13728.0 BP_3 9.00 0.34 1568 -- -- -- -- -- 768311756 CP010984.1 1469 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- -- -- -- -- PF15761//PF03286//PF09026//PF01056 Immortalisation up-regulated protein//Pox virus Ag35 surface protein//Centromere protein B dimerisation domain//Myc amino-terminal region GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003682//GO:0003700 DNA binding//chromatin binding//transcription factor activity, sequence-specific DNA binding GO:0019031//GO:0005667//GO:0005634//GO:0000785//GO:0000775 viral envelope//transcription factor complex//nucleus//chromatin//chromosome, centromeric region -- -- Cluster-13747.0 BP_3 7.00 0.38 1184 33087164 AAP92779.1 419 2.0e-38 hemocyte kazal-type proteinase inhibitor [Penaeus monodon] -- -- -- -- -- -- -- -- -- P31696 291 5.7e-25 Agrin OS=Gallus gallus GN=AGRN PE=1 SV=3 PF07648//PF00050//PF03554 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain//UL73 viral envelope glycoprotein -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-13752.0 BP_3 51.00 0.99 2776 675367441 KFM60343.1 2153 4.0e-239 Polyadenylate-binding protein 1, partial [Stegodyphus mimosarum] 768921143 XM_003965840.2 220 6.33139e-109 PREDICTED: Takifugu rubripes poly(A) binding protein, cytoplasmic 1 (pabpc1), mRNA K13126 PABPC polyadenylate-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13126 P20965 1885 2.0e-209 Polyadenylate-binding protein 1-A OS=Xenopus laevis GN=pabpc1-a PE=1 SV=3 PF04815//PF08777//PF09377//PF00658//PF16367//PF00076 Sec23/Sec24 helical domain//RNA binding motif//SBDS protein C-terminal domain//Poly-adenylate binding protein, unique domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006888//GO:0006886//GO:0042254 ER to Golgi vesicle-mediated transport//intracellular protein transport//ribosome biogenesis GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0030127 COPII vesicle coat KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-13757.1 BP_3 2.00 1.11 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1376.0 BP_3 1.00 0.71 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13761.1 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13761.3 BP_3 12.16 0.64 1209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13776.0 BP_3 3.00 0.57 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13778.0 BP_3 4.00 0.48 691 494593975 AGL39312.1 882 2.4e-92 8-lipoxygenase [Penaeus monodon] -- -- -- -- -- K00461 ALOX5 arachidonate 5-lipoxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00461 P09917 296 8.7e-26 Arachidonate 5-lipoxygenase OS=Homo sapiens GN=ALOX5 PE=1 SV=2 PF00305 Lipoxygenase GO:0055114 oxidation-reduction process GO:0046872//GO:0016702 metal ion binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen -- -- -- -- Cluster-13779.0 BP_3 4.00 0.61 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF16866//PF00130 PHD-finger//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-1378.0 BP_3 21.80 0.73 1730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13783.1 BP_3 2.00 1.23 367 470295459 XP_004345062.1 563 1.2e-55 valosin-containing protein [Capsaspora owczarzaki ATCC 30864]>gi|765555330|gb|KJE95921.1| valosin-containing protein [Capsaspora owczarzaki ATCC 30864] 768311755 CP010983.1 367 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q5AWS6 595 9.8e-61 Cell division control protein 48 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=cdc48 PE=1 SV=2 PF07728//PF00004//PF07724 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily) -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- KOG0730 AAA+-type ATPase Cluster-13786.0 BP_3 4.00 0.51 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13788.0 BP_3 4.00 0.36 826 759051578 XP_011334903.1 703 1.6e-71 PREDICTED: anoctamin-8 isoform X5 [Cerapachys biroi] 241616514 XM_002407927.1 152 1.15808e-71 Ixodes scapularis transmembrane protein 16K, putative, mRNA K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q6PB70 552 2.2e-55 Anoctamin-8 OS=Mus musculus GN=Ano8 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2513 Protein required for meiotic chromosome segregation Cluster-13794.0 BP_3 2.00 0.59 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13798.0 BP_3 9.00 2.33 478 156362157 XP_001625647.1 612 3.3e-61 predicted protein [Nematostella vectensis]>gi|156212490|gb|EDO33547.1| predicted protein [Nematostella vectensis] 697073707 XM_009653196.1 478 0 Verticillium dahliae VdLs.17 40S ribosomal protein S4-A mRNA K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 P87158 618 2.8e-63 40S ribosomal protein S4-A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rps401 PE=2 SV=2 PF01479 S4 domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840 ribosome KOG0378 40S ribosomal protein S4 Cluster-13802.1 BP_3 2.00 0.40 531 498999364 XP_004534078.1 403 6.4e-37 PREDICTED: ornithine aminotransferase, mitochondrial [Ceratitis capitata] -- -- -- -- -- K00819 rocD, OAT ornithine--oxo-acid transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00819 Q9VW26 388 1.4e-36 Ornithine aminotransferase, mitochondrial OS=Drosophila melanogaster GN=Oat PE=2 SV=1 PF00202 Aminotransferase class-III -- -- GO:0008483//GO:0030170 transaminase activity//pyridoxal phosphate binding -- -- KOG1402 Ornithine aminotransferase Cluster-13811.0 BP_3 9.24 0.93 772 -- -- -- -- -- 697067364 XM_009650572.1 724 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13811.1 BP_3 19.76 1.49 932 -- -- -- -- -- 302414279 XM_003004926.1 761 0 Verticillium albo-atrum VaMs.102 hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13819.0 BP_3 12.00 0.36 1889 332847660 XP_511477.3 1584 2.6e-173 PREDICTED: C-C chemokine receptor type 7 [Pan troglodytes] 683523919 NM_001301718.1 1889 0 Homo sapiens chemokine (C-C motif) receptor 7 (CCR7), transcript variant 5, mRNA K04182 CCR7 C-C chemokine receptor type 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04182 P32248 1584 1.1e-174 C-C chemokine receptor type 7 OS=Homo sapiens GN=CCR7 PE=2 SV=2 PF04145//PF09726//PF00001//PF01527 Ctr copper transporter family//Transmembrane protein//7 transmembrane receptor (rhodopsin family)//Transposase GO:0006825//GO:0006313//GO:0007186//GO:0035434 copper ion transport//transposition, DNA-mediated//G-protein coupled receptor signaling pathway//copper ion transmembrane transport GO:0003677//GO:0004930//GO:0004803//GO:0005375 DNA binding//G-protein coupled receptor activity//transposase activity//copper ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-13822.0 BP_3 3.00 1.10 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1383.0 BP_3 2.00 0.40 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13834.1 BP_3 2.00 0.59 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1384.0 BP_3 9.00 1.78 535 -- -- -- -- -- 110681739 AC154129.2 108 2.11016e-47 Tribolium castaneum BAC T.cast_C6G7 () complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13842.0 BP_3 3.43 0.40 707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00105 Zinc finger, C4 type (two domains) GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-13844.2 BP_3 7.00 0.54 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726//PF07464//PF03480//PF00210//PF00430//PF01442//PF03586//PF01297 Transmembrane protein//Apolipophorin-III precursor (apoLp-III)//Bacterial extracellular solute-binding protein, family 7//Ferritin-like domain//ATP synthase B/B' CF(0)//Apolipoprotein A1/A4/E domain//Herpesvirus UL36 tegument protein//Zinc-uptake complex component A periplasmic GO:0042157//GO:0030001//GO:0006869//GO:0006508//GO:0015986//GO:0039693//GO:0006879//GO:0006810//GO:0015992 lipoprotein metabolic process//metal ion transport//lipid transport//proteolysis//ATP synthesis coupled proton transport//viral DNA genome replication//cellular iron ion homeostasis//transport//proton transport GO:0008289//GO:0046872//GO:0015078//GO:0008199//GO:0019784 lipid binding//metal ion binding//hydrogen ion transmembrane transporter activity//ferric iron binding//NEDD8-specific protease activity GO:0030288//GO:0005576//GO:0016021//GO:0045263 outer membrane-bounded periplasmic space//extracellular region//integral component of membrane//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-13847.0 BP_3 2.00 0.43 514 119624064 EAX03659.1 692 1.9e-70 major histocompatibility complex, class II, DM alpha, isoform CRA_b [Homo sapiens] 207113141 NM_006120.3 494 0 Homo sapiens major histocompatibility complex, class II, DM alpha (HLA-DMA), mRNA K06752 MHC2 major histocompatibility complex, class II http://www.genome.jp/dbget-bin/www_bget?ko:K06752 P28067 637 1.9e-65 HLA class II histocompatibility antigen, DM alpha chain OS=Homo sapiens GN=HLA-DMA PE=1 SV=1 PF06743 FAST kinase-like protein, subdomain 1 -- -- GO:0004672 protein kinase activity -- -- -- -- Cluster-1385.0 BP_3 3.00 1.05 429 642932736 XP_008196966.1 321 1.7e-27 PREDICTED: enhancer of split malpha protein-like [Tribolium castaneum]>gi|270012429|gb|EFA08877.1| hypothetical protein TcasGA2_TC006578 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15952 Enhancer of split M4 family GO:0007423//GO:0007219 sensory organ development//Notch signaling pathway -- -- -- -- -- -- Cluster-13850.0 BP_3 11.81 2.02 574 22758848 AAN05584.1 406 3.1e-37 ribosomal protein L30 [Argopecten irradians] 697072802 XM_009652887.1 574 0 Verticillium dahliae VdLs.17 60S ribosomal protein L30 mRNA K02908 RP-L30e, RPL30 large subunit ribosomal protein L30e http://www.genome.jp/dbget-bin/www_bget?ko:K02908 Q7S7F1 447 2.2e-43 60S ribosomal protein L30 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-30 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2988 60S ribosomal protein L30 Cluster-13851.0 BP_3 58.79 4.73 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13851.1 BP_3 15.21 1.26 875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13858.0 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13860.0 BP_3 9.00 0.37 1472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13863.0 BP_3 5.00 1.62 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097 Arthropod defensin GO:0006952 defense response -- -- -- -- -- -- Cluster-13866.0 BP_3 9.00 1.51 579 -- -- -- -- -- 697082532 XM_009656245.1 552 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13868.1 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13872.0 BP_3 3.00 0.32 748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13890.0 BP_3 168.00 7.13 1427 642914631 XP_008190292.1 479 2.7e-45 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0046872//GO:0003676//GO:0016787 metal ion binding//nucleic acid binding//hydrolase activity -- -- -- -- Cluster-13893.0 BP_3 1.00 0.64 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13898.0 BP_3 2.00 0.36 563 -- -- -- -- -- 768311759 CP010987.1 563 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- PF16557//PF04082 CUT1-like DNA-binding domain of SATB//Fungal specific transcription factor domain GO:0006351 transcription, DNA-templated GO:0008270//GO:0003677 zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-139.0 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07065 D123 GO:0007049 cell cycle -- -- -- -- -- -- Cluster-1390.0 BP_3 2.00 0.43 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13908.0 BP_3 3.00 0.42 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13909.0 BP_3 5.00 3.14 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1391.0 BP_3 8.00 0.66 877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13911.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13913.0 BP_3 1.00 0.35 427 -- -- -- -- -- 525346432 KC793905.1 199 4.30021e-98 Scylla paramamosain clone Scpa13 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13914.0 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13917.0 BP_3 4.64 0.35 930 270013290 EFA09738.1 175 3.1e-10 hypothetical protein TcasGA2_TC011873 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13918.0 BP_3 1.00 0.31 445 241727892 XP_002413783.1 366 1.0e-32 sodium/glucose cotransporter, putative [Ixodes scapularis]>gi|215507599|gb|EEC17091.1| sodium/glucose cotransporter, putative, partial [Ixodes scapularis] -- -- -- -- -- K14382 SLC5A2, SGLT2 solute carrier family 5 (sodium/glucose cotransporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14382 P53792 298 3.3e-26 Sodium/glucose cotransporter 2 OS=Rattus norvegicus GN=Slc5a2 PE=2 SV=1 PF00137//PF00474 ATP synthase subunit C//Sodium:solute symporter family GO:0055085//GO:0006810//GO:0015991//GO:0015992 transmembrane transport//transport//ATP hydrolysis coupled proton transport//proton transport GO:0005215//GO:0015078 transporter activity//hydrogen ion transmembrane transporter activity GO:0016021//GO:0033177//GO:0016020 integral component of membrane//proton-transporting two-sector ATPase complex, proton-transporting domain//membrane -- -- Cluster-13920.0 BP_3 2.00 0.39 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13923.0 BP_3 8.00 0.49 1072 873231242 CEM08806.1 293 7.4e-24 unnamed protein product [Vitrella brassicaformis CCMP3155] 768311759 CP010987.1 1054 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- O13899 457 2.9e-44 Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC22A12.08c PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1618 Predicted phosphatase Cluster-13926.0 BP_3 15.00 1.99 655 189236545 XP_001816234.1 481 7.1e-46 PREDICTED: uncharacterized protein LOC100142571 [Tribolium castaneum]>gi|270006031|gb|EFA02479.1| hypothetical protein TcasGA2_TC008170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-13936.0 BP_3 24.14 0.92 1551 642925556 XP_971635.2 279 4.5e-22 PREDICTED: estrogen sulfotransferase [Tribolium castaneum] -- -- -- -- -- K01025 E2.8.2.- -- http://www.genome.jp/dbget-bin/www_bget?ko:K01025 Q95JD5 184 1.9e-12 Sulfotransferase family cytosolic 1B member 1 OS=Canis familiaris GN=SULT1B1 PE=1 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-13949.0 BP_3 3.00 0.44 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13950.0 BP_3 3.00 0.92 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13959.0 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1396.0 BP_3 24.02 1.24 1229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13966.0 BP_3 5.00 0.50 773 742408646 AJB28949.1 573 1.8e-56 c-Jun protein [Litopenaeus vannamei] -- -- -- -- -- K04449 JUND transcription factor jun-D http://www.genome.jp/dbget-bin/www_bget?ko:K04449 P18870 260 1.5e-21 Transcription factor AP-1 OS=Gallus gallus GN=JUN PE=1 SV=2 PF00170//PF07716//PF03131 bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-13966.1 BP_3 4.00 0.47 702 742408646 AJB28949.1 507 7.4e-49 c-Jun protein [Litopenaeus vannamei] -- -- -- -- -- K04448 JUN transcription factor AP-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04448 P05412 358 5.7e-33 Transcription factor AP-1 OS=Homo sapiens GN=JUN PE=1 SV=2 PF03131//PF04977//PF00170//PF07716//PF06005 bZIP Maf transcription factor//Septum formation initiator//bZIP transcription factor//Basic region leucine zipper//Protein of unknown function (DUF904) GO:0043093//GO:0000917//GO:0007049//GO:0006355 FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005737 transcription factor complex//nucleus//cytoplasm KOG0837 Transcriptional activator of the JUN family Cluster-13973.0 BP_3 1.00 0.36 425 -- -- -- -- -- 768311759 CP010987.1 413 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13978.0 BP_3 3.00 0.50 581 91083101 XP_969476.1 436 1.0e-40 PREDICTED: protein lifeguard 4 [Tribolium castaneum]>gi|270006991|gb|EFA03439.1| hypothetical protein TcasGA2_TC013429 [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q9HC24 348 6.9e-32 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-13979.0 BP_3 40.00 3.61 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01047 MarR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-13984.0 BP_3 13.00 0.68 1208 260801887 XP_002595826.1 891 3.8e-93 hypothetical protein BRAFLDRAFT_115715 [Branchiostoma floridae]>gi|229281075|gb|EEN51838.1| hypothetical protein BRAFLDRAFT_115715 [Branchiostoma floridae] 697073948 XM_009653281.1 933 0 Verticillium dahliae VdLs.17 transaldolase partial mRNA K00616 E2.2.1.2, talA, talB transaldolase http://www.genome.jp/dbget-bin/www_bget?ko:K00616 J9MJK9 1234 2.6e-134 Transaldolase OS=Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) GN=FOXG_03074 PE=1 SV=1 PF06662//PF00923 D-glucuronyl C5-epimerase C-terminus//Transaldolase GO:0006024//GO:0005975 glycosaminoglycan biosynthetic process//carbohydrate metabolic process GO:0003824//GO:0016857 catalytic activity//racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016021 integral component of membrane KOG2772 Transaldolase Cluster-13984.2 BP_3 3.00 0.49 588 336454162 AEI58895.1 349 1.3e-30 cathepsin D [Pteria penguin] 697065638 XM_009649711.1 579 0 Verticillium dahliae VdLs.17 vacuolar protease A mRNA K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q01294 570 1.3e-57 Vacuolar protease A OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=pep-4 PE=3 SV=2 PF02806//PF00026 Alpha amylase, C-terminal all-beta domain//Eukaryotic aspartyl protease GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0003824//GO:0043169//GO:0004190 catalytic activity//cation binding//aspartic-type endopeptidase activity -- -- KOG1339 Aspartyl protease Cluster-13986.0 BP_3 4.00 0.89 508 -- -- -- -- -- 697069406 XM_009651592.1 383 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- Q9UTI9 155 1.4e-09 UPF0591 membrane protein C15E1.02c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.02c PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-13987.0 BP_3 3.00 1.15 416 241998180 XP_002433733.1 219 1.1e-15 ubiquinol-cytochrome C reductase hinge protein, putative [Ixodes scapularis]>gi|215495492|gb|EEC05133.1| ubiquinol-cytochrome C reductase hinge protein, putative [Ixodes scapularis] 262401202 FJ774783.1 246 3.11915e-124 Scylla paramamosain mitochondrial ubiquinol-cytochrome c reductase complex 11 kDa protein mRNA, partial cds; nuclear gene for mitochondrial product K00416 QCR6, UQCRH ubiquinol-cytochrome c reductase subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00416 P07919 172 1.3e-11 Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens GN=UQCRH PE=1 SV=2 -- -- GO:0006122//GO:0006118//GO:0006119//GO:0015992 mitochondrial electron transport, ubiquinol to cytochrome c//obsolete electron transport//oxidative phosphorylation//proton transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-14.0 BP_3 18.00 2.96 585 478261790 ENN80920.1 278 2.2e-22 hypothetical protein YQE_02667, partial [Dendroctonus ponderosae]>gi|546681104|gb|ERL91260.1| hypothetical protein D910_08594 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P82166 275 2.0e-23 Cuticle protein 19.8 OS=Locusta migratoria PE=1 SV=1 PF05104//PF00379 Ribosome receptor lysine/proline rich region//Insect cuticle protein GO:0015031 protein transport GO:0042302 structural constituent of cuticle GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-140.0 BP_3 4.00 0.72 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14000.1 BP_3 34.11 0.91 2089 557332086 XP_006038864.1 931 1.5e-97 PREDICTED: zinc finger protein 850-like [Alligator sinensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q14591 897 5.4e-95 Zinc finger protein 271 OS=Homo sapiens GN=ZNF271 PE=2 SV=4 PF13912//PF02892//PF07776//PF00096//PF13465 C2H2-type zinc finger//BED zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-14009.0 BP_3 3.00 0.44 624 675384101 KFM76998.1 189 4.9e-12 Cytochrome b-c1 complex subunit 9, partial [Stegodyphus mimosarum] -- -- -- -- -- K00419 QCR9, UCRC ubiquinol-cytochrome c reductase subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K00419 P00130 176 6.5e-12 Cytochrome b-c1 complex subunit 9 OS=Bos taurus GN=UQCR10 PE=1 SV=3 PF15462//PF05365//PF15761 Bartter syndrome, infantile, with sensorineural deafness (Barttin)//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Immortalisation up-regulated protein GO:0006821//GO:0006122 chloride transport//mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005634//GO:0005743 mitochondrial respiratory chain complex III//nucleus//mitochondrial inner membrane -- -- Cluster-1401.0 BP_3 4.00 0.72 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14018.1 BP_3 2.00 0.75 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14020.0 BP_3 3.00 0.51 577 221110953 XP_002162621.1 276 3.7e-22 PREDICTED: 10 kDa heat shock protein, mitochondrial-like [Hydra vulgaris] 697070055 XM_009651904.1 568 0 Verticillium dahliae VdLs.17 heat shock protein mRNA K04078 groES, HSPE1 chaperonin GroES http://www.genome.jp/dbget-bin/www_bget?ko:K04078 O59804 320 1.2e-28 10 kDa heat shock protein, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hsp10 PE=1 SV=1 PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm KOG1641 Mitochondrial chaperonin Cluster-14022.0 BP_3 2.00 1.58 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14023.0 BP_3 4.00 0.58 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14027.0 BP_3 2.00 0.78 414 -- -- -- -- -- 768311759 CP010987.1 404 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14029.0 BP_3 3.17 0.31 792 642914918 XP_008190441.1 322 2.4e-27 PREDICTED: WD repeat-containing protein 34-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400//PF15184//PF02497 WD domain, G-beta repeat//Mitochondrial import receptor subunit TOM6 homolog//Arterivirus glycoprotein -- -- GO:0005515 protein binding GO:0019031//GO:0005742 viral envelope//mitochondrial outer membrane translocase complex -- -- Cluster-14035.0 BP_3 3.00 0.40 651 328900207 AEB54658.1 532 8.6e-52 H+ transporting ATP synthase O subunit [Procambarus clarkii] -- -- -- -- -- K02137 ATPeF0O, ATP5O, ATP5 F-type H+-transporting ATPase subunit O http://www.genome.jp/dbget-bin/www_bget?ko:K02137 Q24439 420 3.4e-40 ATP synthase subunit O, mitochondrial OS=Drosophila melanogaster GN=Oscp PE=2 SV=2 PF00213 ATP synthase delta (OSCP) subunit GO:0015986 ATP synthesis coupled proton transport GO:0046933 proton-transporting ATP synthase activity, rotational mechanism GO:0045259 proton-transporting ATP synthase complex KOG1662 Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 Cluster-1404.0 BP_3 2.00 0.61 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14040.0 BP_3 2.00 1.00 386 -- -- -- -- -- 768311752 CP010980.1 383 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14040.1 BP_3 1.00 0.54 378 -- -- -- -- -- 768311752 CP010980.1 252 1.298e-127 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14048.0 BP_3 4.00 0.74 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14049.0 BP_3 5.00 0.52 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14052.0 BP_3 9.00 0.76 862 225713132 ACO12412.1 522 1.7e-50 60S ribosomal protein L9 [Lepeophtheirus salmonis]>gi|290561218|gb|ADD38011.1| 60S ribosomal protein L9 [Lepeophtheirus salmonis] 697068441 XM_009651110.1 859 0 Verticillium dahliae VdLs.17 60S ribosomal protein L9 mRNA K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 P51401 603 2.8e-61 60S ribosomal protein L9-B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL9B PE=1 SV=1 PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-14054.0 BP_3 3.00 0.31 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14058.0 BP_3 1.00 0.32 440 328802835 AEB41038.1 543 3.1e-53 selenophosphate synthetase [Penaeus monodon] 826497213 XM_012685829.1 65 1.37334e-23 PREDICTED: Monomorium pharaonis selenide, water dikinase (LOC105839489), mRNA K01008 selD, SEPHS selenide, water dikinase http://www.genome.jp/dbget-bin/www_bget?ko:K01008 O18373 319 1.2e-28 Selenide, water dikinase OS=Drosophila melanogaster GN=SelD PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3939 Selenophosphate synthetase Cluster-14062.0 BP_3 2.00 4.24 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14063.0 BP_3 65.24 2.27 1676 546684650 ERL94267.1 904 1.6e-94 hypothetical protein D910_11548 [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 P23645 710 2.1e-73 Neurogenic protein big brain OS=Drosophila melanogaster GN=bib PE=1 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-14065.2 BP_3 4.00 0.41 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14066.0 BP_3 2.00 0.31 598 167888833 ACA09717.1 871 3.9e-91 ubiquitin-conjugating enyzme E2r [Marsupenaeus japonicus] 240974025 XM_002401687.1 201 4.7571e-99 Ixodes scapularis ubiquitin protein ligase, putative, mRNA K02207 UBE2R, UBC3, CDC34 ubiquitin-conjugating enzyme E2 R http://www.genome.jp/dbget-bin/www_bget?ko:K02207 Q712K3 712 4.4e-74 Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens GN=UBE2R2 PE=1 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0425 Ubiquitin-protein ligase Cluster-14072.0 BP_3 6.00 0.39 1039 641649897 XP_008187410.1 256 1.4e-19 PREDICTED: uncharacterized protein LOC103310547 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-14073.0 BP_3 5.00 0.31 1057 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14076.0 BP_3 27.30 4.40 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14082.0 BP_3 11.00 1.31 697 171189511 ACB42236.1 510 3.3e-49 glutathione peroxidase [Metapenaeus ensis]>gi|171189513|gb|ACB42237.1| glutathione peroxidase [Metapenaeus ensis] -- -- -- -- -- K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 P30710 428 4.4e-41 Epididymal secretory glutathione peroxidase OS=Rattus norvegicus GN=Gpx5 PE=2 SV=1 PF00255 Glutathione peroxidase GO:0006804//GO:0055114//GO:0006979//GO:0006749 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress//glutathione metabolic process GO:0004602//GO:0004601 glutathione peroxidase activity//peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-14099.0 BP_3 8.63 1.46 577 694525039 XP_009492324.1 309 5.5e-26 40S ribosomal protein [Fonticula alba]>gi|627950834|gb|KCV72623.1| 40S ribosomal protein [Fonticula alba] 697090075 XM_009659649.1 516 0 Verticillium dahliae VdLs.17 40S ribosomal protein S26E mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 P21772 445 3.8e-43 40S ribosomal protein S26E OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-26 PE=3 SV=2 PF01283 Ribosomal protein S26e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1768 40s ribosomal protein S26 Cluster-14101.0 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1411.0 BP_3 2.00 0.42 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14115.0 BP_3 5.00 0.31 1071 -- -- -- -- -- 697066096 XM_009649940.1 841 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF10099 Anti-sigma-K factor rskA -- -- -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-14122.0 BP_3 4.00 0.37 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14124.0 BP_3 9.00 0.69 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14128.0 BP_3 1.00 2.28 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14135.0 BP_3 4.00 0.37 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00747 ssDNA binding protein GO:0006260 DNA replication GO:0003697 single-stranded DNA binding GO:0042025 host cell nucleus -- -- Cluster-14140.0 BP_3 1.00 0.34 434 166952385 ABZ04275.1 595 2.8e-59 ribosomal protein rpsA [Lineus viridis] 768311756 CP010984.1 430 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence K02998 RP-SAe, RPSA small subunit ribosomal protein SAe http://www.genome.jp/dbget-bin/www_bget?ko:K02998 Q2GV75 719 4.9e-75 40S ribosomal protein S0 OS=Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) GN=RPS0 PE=3 SV=1 PF02993//PF00318 Minor capsid protein VI//Ribosomal protein S2 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0019028 intracellular//ribosome//viral capsid KOG0830 40S ribosomal protein SA (P40)/Laminin receptor 1 Cluster-14141.0 BP_3 16.71 1.08 1039 91094721 XP_970562.1 553 5.1e-54 PREDICTED: solute carrier family 22 member 1 [Tribolium castaneum]>gi|270016527|gb|EFA12973.1| hypothetical protein TcasGA2_TC010997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75751 156 2.3e-09 Solute carrier family 22 member 3 OS=Homo sapiens GN=SLC22A3 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-14148.0 BP_3 4.00 0.34 854 478253480 ENN73807.1 1156 5.0e-124 hypothetical protein YQE_09585, partial [Dendroctonus ponderosae]>gi|546679136|gb|ERL89641.1| hypothetical protein D910_07006 [Dendroctonus ponderosae] 242001301 XM_002435249.1 291 6.44396e-149 Ixodes scapularis Kruppel-like zinc finger protein, putative, mRNA K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 1092 5.4e-118 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 PF00651//PF00917 BTB/POZ domain//MATH domain -- -- GO:0005515 protein binding -- -- KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-14153.0 BP_3 45.87 3.54 917 642935895 XP_008198218.1 627 1.2e-62 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270013255|gb|EFA09703.1| hypothetical protein TcasGA2_TC011836 [Tribolium castaneum] -- -- -- -- -- K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 Q7ZU92 262 1.0e-21 Poly(A)-specific ribonuclease PARN OS=Danio rerio GN=parn PE=1 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-14156.1 BP_3 5.00 1.24 486 115443537 YP_778556.1 498 5.6e-48 ATP synthase CF0 A chain [Bigelowiella natans]>gi|122239927|sp|Q06J71.1|ATPI_BIGNA RecName: Full=ATP synthase subunit a, chloroplastic; AltName: Full=ATP synthase F0 sector subunit a; AltName: Full=F-ATPase subunit IV (chloroplast) [Bigelowiella natans]>gi|110810182|gb|ABG91388.1| ATP synthase CF0 A chain [Bigelowiella natans] 597569085 KF990036.1 486 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- Q09X29 814 5.3e-86 ATP synthase subunit a, chloroplastic OS=Morus indica GN=atpI PE=3 SV=1 PF00119 ATP synthase A chain GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0016021//GO:0045263//GO:0009535 integral component of membrane//proton-transporting ATP synthase complex, coupling factor F(o)//chloroplast thylakoid membrane -- -- Cluster-14158.1 BP_3 62.00 4.72 925 332376334 AEE63307.1 858 1.9e-89 unknown [Dendroctonus ponderosae]>gi|478257148|gb|ENN77311.1| hypothetical protein YQE_06137, partial [Dendroctonus ponderosae]>gi|546681446|gb|ERL91543.1| hypothetical protein D910_08873 [Dendroctonus ponderosae] -- -- -- -- -- K02537 MAD2 mitotic spindle assembly checkpoint protein MAD2 http://www.genome.jp/dbget-bin/www_bget?ko:K02537 Q556Y9 494 1.3e-48 Mitotic spindle assembly checkpoint protein MAD2A OS=Dictyostelium discoideum GN=mad2l1-1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3285 Spindle assembly checkpoint protein Cluster-14162.0 BP_3 6.18 0.40 1034 765337696 XP_011493198.1 735 4.0e-75 AAEL003675-PB [Aedes aegypti]>gi|403182596|gb|EJY57498.1| AAEL003675-PB [Aedes aegypti] 333755412 HQ161710.1 77 7.19918e-30 Drosophila ficusphila strain 14025-0441.00 Rieske iron-sulfur protein (RFeSP) gene, partial cds K00411 UQCRFS1, RIP1, petA ubiquinol-cytochrome c reductase iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00411 Q69BJ7 694 9.3e-72 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Saimiri sciureus GN=UQCRFS1 PE=3 SV=1 PF09165//PF02921//PF00355 Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//Ubiquinol cytochrome reductase transmembrane region//Rieske [2Fe-2S] domain GO:0006118//GO:0055114//GO:0006119//GO:0015992 obsolete electron transport//oxidation-reduction process//oxidative phosphorylation//proton transport GO:0051537//GO:0008121//GO:0016491 2 iron, 2 sulfur cluster binding//ubiquinol-cytochrome-c reductase activity//oxidoreductase activity -- -- KOG1671 Ubiquinol cytochrome c reductase, subunit RIP1 Cluster-14163.0 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14171.0 BP_3 2.00 0.34 572 294718621 ADF32023.1 465 4.5e-44 galectin [Eriocheir sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00337//PF02793 Galactoside-binding lectin//Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0030246 G-protein coupled receptor activity//carbohydrate binding GO:0016020 membrane -- -- Cluster-14175.0 BP_3 8.00 0.46 1127 321479454 EFX90410.1 307 1.8e-25 hypothetical protein DAPPUDRAFT_39837 [Daphnia pulex] -- -- -- -- -- K06847 RGM RGM domain family http://www.genome.jp/dbget-bin/www_bget?ko:K06847 Q6NW40 222 5.4e-17 RGM domain family member B OS=Homo sapiens GN=RGMB PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-14178.0 BP_3 2.00 1.05 381 817075459 XP_012259962.1 448 2.8e-42 PREDICTED: ras-related protein Rab-5B isoform X1 [Athalia rosae] 262401108 FJ774735.1 228 2.87449e-114 Scylla paramamosain rab5 mRNA, partial cds K07889 RAB5C Ras-related protein Rab-5C http://www.genome.jp/dbget-bin/www_bget?ko:K07889 P51148 410 2.9e-39 Ras-related protein Rab-5C OS=Homo sapiens GN=RAB5C PE=1 SV=2 PF08477//PF00735//PF03193//PF01926//PF00071//PF00025//PF04670 Ras of Complex, Roc, domain of DAPkinase//Septin//Protein of unknown function, DUF258//50S ribosome-binding GTPase//Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-14191.0 BP_3 1.00 0.69 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-14192.0 BP_3 12.22 0.32 2131 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14197.0 BP_3 3.00 0.47 599 189240426 XP_971297.2 331 1.6e-28 PREDICTED: neo-calmodulin-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 Q9HFY6 288 6.4e-25 Calmodulin OS=Blastocladiella emersonii GN=CMD1 PE=3 SV=3 PF01346//PF13405//PF10591//PF00036//PF13833//PF13499//PF13202 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain pair//EF-hand domain pair//EF hand GO:0006457//GO:0007165 protein folding//signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-14208.0 BP_3 20.57 0.67 1774 91086047 XP_973605.1 1543 1.4e-168 PREDICTED: protein turtle homolog B [Tribolium castaneum] 642927616 XM_968512.2 282 1.37586e-143 PREDICTED: Tribolium castaneum protein turtle homolog B (LOC662415), mRNA -- -- -- -- O60500 195 1.2e-13 Nephrin OS=Homo sapiens GN=NPHS1 PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-14213.0 BP_3 14.00 0.76 1183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14213.2 BP_3 15.51 0.33 2527 357622584 EHJ74011.1 156 1.3e-07 hypothetical protein KGM_13510 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14217.0 BP_3 4.00 0.32 885 256549318 ACU83213.1 256 1.2e-19 C-type lectin [Ruditapes philippinarum] -- -- -- -- -- K06468 FCER2, CD23 Fc receptor, IgE, low affinity II http://www.genome.jp/dbget-bin/www_bget?ko:K06468 P20693 215 2.8e-16 Low affinity immunoglobulin epsilon Fc receptor OS=Mus musculus GN=Fcer2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-14217.1 BP_3 1.00 2.95 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14221.0 BP_3 2.00 0.74 421 594678955 XP_007187221.1 474 3.0e-45 PREDICTED: 10 kDa heat shock protein, mitochondrial-like [Balaenoptera acutorostrata scammoni] 209574325 NM_002157.2 421 0 Homo sapiens heat shock 10kDa protein 1 (HSPE1), mRNA K04078 groES, HSPE1 chaperonin GroES http://www.genome.jp/dbget-bin/www_bget?ko:K04078 P61603 456 1.5e-44 10 kDa heat shock protein, mitochondrial OS=Bos taurus GN=HSPE1 PE=3 SV=2 PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm KOG1641 Mitochondrial chaperonin Cluster-14225.0 BP_3 5.00 0.38 932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14229.0 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14233.0 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14237.0 BP_3 1.00 0.59 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1424.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1425.0 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14259.0 BP_3 2.00 0.37 555 646721128 KDR22598.1 329 2.5e-28 Protein big brother [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q24040 297 5.4e-26 Protein big brother OS=Drosophila melanogaster GN=Bgb PE=2 SV=3 PF02312 Core binding factor beta subunit -- -- GO:0003713 transcription coactivator activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-14262.0 BP_3 4.00 0.41 759 762114419 XP_011439989.1 445 1.2e-41 PREDICTED: 60S ribosomal protein L32-like [Crassostrea gigas] 697079200 XM_009655095.1 741 0 Verticillium dahliae VdLs.17 60S ribosomal protein L32 mRNA K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q7RXY1 582 6.6e-59 60S ribosomal protein L32 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=crp-63 PE=3 SV=1 PF01655//PF00957 Ribosomal protein L32//Synaptobrevin GO:0042254//GO:0006412//GO:0016192 ribosome biogenesis//translation//vesicle-mediated transport GO:0003735 structural constituent of ribosome GO:0005840//GO:0016021//GO:0005622 ribosome//integral component of membrane//intracellular KOG0878 60S ribosomal protein L32 Cluster-14267.0 BP_3 10.00 0.47 1328 301500958 YP_003795423.1 1873 5.6e-207 photosystem I P700 chlorophyll a apoprotein A2 [Alveolata sp. CCMP3155]>gi|300069504|gb|ADJ66611.1| photosystem I P700 chlorophyll a apoprotein A2 (chloroplast) [Chromerida sp. RM11] 597569085 KF990036.1 1289 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- Q09X18 2396 5.2e-269 Photosystem I P700 chlorophyll a apoprotein A2 OS=Morus indica GN=psaB PE=3 SV=1 PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0009507//GO:0016021//GO:0009522//GO:0009579 chloroplast//integral component of membrane//photosystem I//thylakoid -- -- Cluster-14277.0 BP_3 2.00 0.32 595 826421469 XP_012525694.1 283 5.9e-23 PREDICTED: la-related protein 6 isoform X2 [Monomorium pharaonis] -- -- -- -- -- K18733 LARP6 la-related protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18733 Q8BN59 245 6.2e-20 La-related protein 6 OS=Mus musculus GN=Larp6 PE=1 SV=1 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0018401//GO:0006525//GO:0006560//GO:0055114 peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process//proline metabolic process//oxidation-reduction process GO:0004656//GO:0016702 procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005783 endoplasmic reticulum KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-14280.0 BP_3 10.00 1.26 674 469664397 AGH70153.1 637 6.0e-64 60S ribosomal protein L7, partial [Placozoa sp. H4] 697090338 XM_009659780.1 626 0 Verticillium dahliae VdLs.17 60S ribosomal protein L7 partial mRNA K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 Q7SBD5 813 9.6e-86 60S ribosomal protein L7 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-7 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3184 60S ribosomal protein L7 Cluster-14282.1 BP_3 8.98 0.46 1236 805767235 XP_012135536.1 715 9.9e-73 PREDICTED: RNA-binding protein squid isoform X8 [Megachile rotundata] 194741283 XM_001953084.1 173 3.72035e-83 Drosophila ananassae GF17370 (Dana\GF17370), mRNA K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 710 1.5e-73 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076//PF02950//PF08777//PF11837//PF00335 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Conotoxin//RNA binding motif//Domain of unknown function (DUF3357)//Tetraspanin family GO:0009405//GO:0005982//GO:0006012//GO:0005985//GO:0006810 pathogenesis//starch metabolic process//galactose metabolic process//sucrose metabolic process//transport GO:0003676//GO:0004564//GO:0003723//GO:0004575//GO:0008200 nucleic acid binding//beta-fructofuranosidase activity//RNA binding//sucrose alpha-glucosidase activity//ion channel inhibitor activity GO:0005576//GO:0016021//GO:0017177 extracellular region//integral component of membrane//glucosidase II complex -- -- Cluster-14282.3 BP_3 1.00 9.36 245 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14288.0 BP_3 7.00 2.07 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14292.0 BP_3 35.74 0.69 2803 478258061 ENN78199.1 2771 8.8e-311 hypothetical protein YQE_05351, partial [Dendroctonus ponderosae] 462344103 APGK01035160.1 71 4.30925e-26 Dendroctonus ponderosae Seq01035170, whole genome shotgun sequence K01590 hdc, HDC histidine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01590 Q05733 2063 4.5e-230 Histidine decarboxylase OS=Drosophila melanogaster GN=Hdc PE=2 SV=2 PF07359//PF00282//PF04604 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)//Pyridoxal-dependent decarboxylase conserved domain//Type-A lantibiotic GO:0019752//GO:0042742 carboxylic acid metabolic process//defense response to bacterium GO:0030170//GO:0016831 pyridoxal phosphate binding//carboxy-lyase activity GO:0005576 extracellular region KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-14293.0 BP_3 8.00 0.39 1275 827536514 XP_012553325.1 321 5.0e-27 PREDICTED: uncharacterized protein LOC105843014 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07655//PF04147 Secretin N-terminal domain//Nop14-like family GO:0009297 pilus assembly -- -- GO:0019867//GO:0032040 outer membrane//small-subunit processome -- -- Cluster-14306.0 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14307.0 BP_3 10.67 0.93 845 -- -- -- -- -- 768311759 CP010987.1 477 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14309.0 BP_3 19.44 0.79 1472 766931243 XP_011497794.1 215 1.1e-14 PREDICTED: proline-rich protein 4-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14312.0 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14317.0 BP_3 27.00 1.08 1497 270017042 EFA13488.1 981 1.7e-103 hypothetical protein TcasGA2_TC004227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX7 336 4.4e-30 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-14317.1 BP_3 6.00 0.64 742 270017042 EFA13488.1 449 4.2e-42 hypothetical protein TcasGA2_TC004227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14319.0 BP_3 3.00 0.37 685 345482281 XP_003424561.1 226 2.8e-16 PREDICTED: guanine nucleotide-binding protein subunit gamma-1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- P38040 191 1.3e-13 Guanine nucleotide-binding protein subunit gamma-1 OS=Drosophila melanogaster GN=Ggamma1 PE=2 SV=1 PF00631 GGL domain GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex -- -- Cluster-14320.0 BP_3 11.00 0.48 1387 -- -- -- -- -- 768311758 CP010986.1 1357 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- Q2UUZ1 684 1.8e-70 Probable glucan endo-1,3-beta-glucosidase eglC OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=eglC PE=3 SV=1 PF00332 Glycosyl hydrolases family 17 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-14320.1 BP_3 17.00 1.41 872 700589070 AIU94796.1 538 2.3e-52 hypothetical protein [Phragmatopoma lapidosa] 697089320 XM_009659275.1 734 0 Verticillium dahliae VdLs.17 peptidyl-prolyl cis-trans isomerase partial mRNA K03767 PPIA peptidyl-prolyl cis-trans isomerase A (cyclophilin A) http://www.genome.jp/dbget-bin/www_bget?ko:K03767 P10255 634 7.1e-65 Peptidyl-prolyl cis-trans isomerase, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=csr-1 PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-14321.0 BP_3 3.00 2.11 356 270015511 EFA11959.1 161 4.9e-09 hypothetical protein TcasGA2_TC005046 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14322.1 BP_3 3.00 0.34 714 388548526 AFK65746.1 1017 5.5e-108 ubiquitin-activating enzyme E1 [Eriocheir sinensis] 388548525 JQ061292.1 323 8.69252e-167 Eriocheir sinensis ubiquitin-activating enzyme E1 mRNA, complete cds K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 Q5U300 751 1.6e-78 Ubiquitin-like modifier-activating enzyme 1 OS=Rattus norvegicus GN=Uba1 PE=1 SV=1 PF00899 ThiF family -- -- GO:0008641 small protein activating enzyme activity -- -- KOG2012 Ubiquitin activating enzyme UBA1 Cluster-14323.0 BP_3 3.00 0.44 624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1433.0 BP_3 3.00 0.69 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14331.0 BP_3 1.00 0.64 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1434.0 BP_3 4.00 0.33 880 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14341.0 BP_3 4.00 0.58 624 817086327 XP_012265888.1 304 2.3e-25 PREDICTED: cell division cycle protein 27 homolog [Athalia rosae] -- -- -- -- -- K03350 APC3, CDC27 anaphase-promoting complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03350 P30260 203 4.8e-15 Cell division cycle protein 27 homolog OS=Homo sapiens GN=CDC27 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-14343.0 BP_3 1.56 1.17 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14344.0 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14345.0 BP_3 4.00 0.56 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14345.1 BP_3 19.00 2.06 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1435.0 BP_3 5.00 0.69 639 642920517 XP_008192383.1 282 8.3e-23 PREDICTED: uncharacterized protein LOC662572 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14356.0 BP_3 1.00 0.34 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14357.0 BP_3 1.00 0.52 383 831765815 XP_012751598.1 163 3.1e-09 hypothetical protein SAMD00019534_087870 [Acytostelium subglobosum LB1]>gi|735852230|dbj|GAM25612.1| hypothetical protein SAMD00019534_087870 [Acytostelium subglobosum LB1] 768311759 CP010987.1 383 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- Q09702 309 1.5e-27 Negative regulator of differentiation 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nrd1 PE=1 SV=1 PF08675//PF00076//PF08096//PF08777 RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Bombolitin family//RNA binding motif GO:0006402//GO:0043303//GO:0009405//GO:0051252 mRNA catabolic process//mast cell degranulation//pathogenesis//regulation of RNA metabolic process GO:0003723//GO:0046872//GO:0004535//GO:0003676 RNA binding//metal ion binding//poly(A)-specific ribonuclease activity//nucleic acid binding GO:0005634//GO:0005737//GO:0005576 nucleus//cytoplasm//extracellular region KOG0118 FOG: RRM domain Cluster-14360.0 BP_3 1.00 0.98 333 -- -- -- -- -- 768311752 CP010980.1 307 3.00777e-158 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- PF09606 ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-14365.0 BP_3 15.00 1.03 993 514694820 XP_004994981.1 346 4.9e-30 ribosomal protein L35a [Salpingoeca rosetta]>gi|326437907|gb|EGD83477.1| ribosomal protein L35a [Salpingoeca rosetta] 768311752 CP010980.1 650 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 Q9USX4 408 1.3e-38 60S ribosomal protein L33-A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl35b PE=3 SV=2 PF01247//PF01782 Ribosomal protein L35Ae//RimM N-terminal domain GO:0006364//GO:0042254//GO:0006412 rRNA processing//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-14367.0 BP_3 5.70 0.46 885 91087247 XP_975518.1 237 1.9e-17 PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929756|ref|XP_008195961.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929758|ref|XP_008195962.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929760|ref|XP_008195963.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14369.0 BP_3 4.00 0.75 548 270002979 EEZ99426.1 152 8.4e-08 odorant receptor 322 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949 7tm Odorant receptor GO:0007608//GO:0007187 sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-1438.0 BP_3 16.00 0.72 1358 642916760 XP_008192504.1 2212 2.8e-246 PREDICTED: SCY1-like protein 2 [Tribolium castaneum] 642916759 XM_008194282.1 467 0 PREDICTED: Tribolium castaneum SCY1-like protein 2 (LOC661144), mRNA -- -- -- -- Q6P3W7 694 1.2e-71 SCY1-like protein 2 OS=Homo sapiens GN=SCYL2 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG2137 Protein kinase Cluster-1438.1 BP_3 3.00 0.75 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1438.4 BP_3 21.35 0.71 1745 642916760 XP_008192504.1 1487 4.2e-162 PREDICTED: SCY1-like protein 2 [Tribolium castaneum] 642916759 XM_008194282.1 444 0 PREDICTED: Tribolium castaneum SCY1-like protein 2 (LOC661144), mRNA -- -- -- -- Q8CFE4 297 1.7e-25 SCY1-like protein 2 OS=Mus musculus GN=Scyl2 PE=1 SV=1 PF04928//PF01006 Poly(A) polymerase central domain//Hepatitis C virus non-structural protein NS4a GO:0043631//GO:0016032 RNA polyadenylation//viral process GO:0004652 polynucleotide adenylyltransferase activity GO:0019012 virion -- -- Cluster-14380.0 BP_3 3.00 0.45 615 62088522 BAD92708.1 972 7.8e-103 ribosomal protein L12 variant [Homo sapiens] 324021718 NM_000976.3 615 0 Homo sapiens ribosomal protein L12 (RPL12), mRNA K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61284 849 5.8e-90 60S ribosomal protein L12 OS=Bos taurus GN=RPL12 PE=2 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-1439.0 BP_3 1.00 0.33 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14392.0 BP_3 5.00 0.39 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14396.0 BP_3 1.00 0.34 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14397.0 BP_3 4.00 0.46 713 795015208 XP_011858072.1 236 2.0e-17 PREDICTED: uncharacterized protein LOC105555657 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14398.1 BP_3 4.00 0.80 534 -- -- -- -- -- 525346467 KC793939.1 255 4.04202e-129 Scylla paramamosain clone Scpa47 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14399.0 BP_3 1.00 2.72 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-1440.0 BP_3 1.00 0.75 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14408.0 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14409.0 BP_3 2.00 1.58 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1441.0 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14415.0 BP_3 2.00 0.56 465 321472272 EFX83242.1 344 3.9e-30 hypothetical protein DAPPUDRAFT_315683 [Daphnia pulex] -- -- -- -- -- K04365 BRAF B-Raf proto-oncogene serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04365 P11346 238 3.1e-19 Raf homolog serine/threonine-protein kinase phl OS=Drosophila melanogaster GN=phl PE=1 SV=6 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG0193 Serine/threonine protein kinase RAF Cluster-14420.0 BP_3 1.00 0.37 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14428.0 BP_3 2.00 0.42 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14430.0 BP_3 4.00 0.54 651 342326199 AEL23015.1 317 7.4e-27 protein spaetzle [Cherax quadricarinatus] 262401216 FJ774790.1 192 5.24108e-94 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF00243 Nerve growth factor family GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-14440.0 BP_3 22.00 1.00 1355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14444.0 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14446.0 BP_3 13.72 0.72 1215 270012615 EFA09063.1 201 3.9e-13 hypothetical protein TcasGA2_TC006778 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14448.0 BP_3 2.00 0.96 390 82795529 ABB91678.1 237 8.4e-18 calcified cuticle protein CP6.1 [Callinectes sapidus] 82795528 DQ288153.1 196 1.81281e-96 Callinectes sapidus calcified cuticle protein CP6.1 mRNA, complete cds -- -- -- -- P81589 167 4.5e-11 Cuticle protein CP575 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-14449.0 BP_3 2.00 0.64 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14450.0 BP_3 6.00 0.68 716 -- -- -- -- -- 697089006 XM_009659118.1 713 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14450.1 BP_3 2.00 0.41 524 -- -- -- -- -- 768311759 CP010987.1 498 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14452.0 BP_3 3.00 0.81 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14453.0 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14459.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14472.1 BP_3 3.00 1.14 418 -- -- -- -- -- 404312705 AC253545.1 387 0 Prunus persica clone JGIBIXB-13E11, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14488.0 BP_3 2.00 2.64 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14492.0 BP_3 1.00 1.18 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14494.0 BP_3 3.00 0.33 731 755954819 XP_011302900.1 221 1.1e-15 PREDICTED: NADH-ubiquinone oxidoreductase subunit 8 [Fopius arisanus] 597569085 KF990036.1 558 0 Prunus kansuensis chloroplast, complete genome K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 Q0ZIW4 859 4.8e-91 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic OS=Vitis vinifera GN=ndhI PE=3 SV=1 PF00146 NADH dehydrogenase GO:0055114 oxidation-reduction process -- -- GO:0016020 membrane -- -- Cluster-14504.0 BP_3 13.00 1.25 792 662186613 XP_008483033.1 190 4.8e-12 PREDICTED: uncharacterized protein LOC103519719 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P82120 145 3.3e-08 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-14525.0 BP_3 8.08 0.37 1332 805767231 XP_012135534.1 715 1.1e-72 PREDICTED: RNA-binding protein squid isoform X6 [Megachile rotundata] 194741283 XM_001953084.1 173 4.01773e-83 Drosophila ananassae GF17370 (Dana\GF17370), mRNA K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 710 1.7e-73 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF00076//PF16367//PF08777//PF10717//PF00335 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif//Occlusion-derived virus envelope protein ODV-E18//Tetraspanin family -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-14526.0 BP_3 4.00 0.59 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07881//PF00083 L-fucose isomerase, first N-terminal domain//Sugar (and other) transporter GO:0006000//GO:0006013//GO:0006004//GO:0055085 fructose metabolic process//mannose metabolic process//fucose metabolic process//transmembrane transport GO:0008736//GO:0022857 L-fucose isomerase activity//transmembrane transporter activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-14526.2 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14528.1 BP_3 1.00 0.50 387 66828395 XP_647552.1 362 2.6e-32 4-aminobutyrate transaminase [Dictyostelium discoideum AX4]>gi|74897469|sp|Q55FI1.1|GABT_DICDI RecName: Full=4-aminobutyrate aminotransferase; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase>gi|60475570|gb|EAL73505.1| 4-aminobutyrate transaminase [Dictyostelium discoideum AX4] 768311759 CP010987.1 387 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 P14010 419 2.7e-40 4-aminobutyrate aminotransferase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=gatA PE=3 SV=1 PF00202 Aminotransferase class-III -- -- GO:0008483//GO:0030170 transaminase activity//pyridoxal phosphate binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-1453.0 BP_3 5.00 0.79 595 -- -- -- -- -- 697074390 XM_009653435.1 561 0 Verticillium dahliae VdLs.17 Fmp45p partial mRNA -- -- -- -- Q07651 169 4.0e-11 SUR7 family protein FMP45 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FMP45 PE=1 SV=1 PF06687 SUR7/PalI family -- -- -- -- GO:0005886 plasma membrane -- -- Cluster-14530.0 BP_3 3.00 0.42 640 646709975 KDR15614.1 589 2.1e-58 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [Zootermopsis nevadensis] -- -- -- -- -- K05631 AIP3, WWP3, BAIAP1 atrophin-1 interacting protein 3 (BAI1-associated protein 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05631 Q6RHR9 468 9.2e-46 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 OS=Mus musculus GN=Magi1 PE=1 SV=1 PF00595//PF13180//PF00397 PDZ domain (Also known as DHR or GLGF)//PDZ domain//WW domain -- -- GO:0005515 protein binding -- -- KOG3209 WW domain-containing protein Cluster-14534.0 BP_3 2.00 0.48 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14535.0 BP_3 2.00 0.67 435 391328145 XP_003738552.1 465 3.4e-44 PREDICTED: enolase-like [Metaseiulus occidentalis] 768311757 CP010985.1 409 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 Q7RV85 576 1.9e-58 Enolase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=emp-7 PE=3 SV=1 PF03952 Enolase, N-terminal domain GO:0009094//GO:0006094//GO:0000162//GO:0006571//GO:0006096 L-phenylalanine biosynthetic process//gluconeogenesis//tryptophan biosynthetic process//tyrosine biosynthetic process//glycolytic process GO:0000287//GO:0004634 magnesium ion binding//phosphopyruvate hydratase activity GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-14535.1 BP_3 7.00 0.46 1018 229366696 ACQ58328.1 1000 7.3e-106 Alpha-enolase [Anoplopoma fimbria] 697084396 XM_009656894.1 1015 0 Verticillium dahliae VdLs.17 enolase mRNA K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 Q7RV85 1424 2.1e-156 Enolase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=emp-7 PE=3 SV=1 PF00113//PF01596 Enolase, C-terminal TIM barrel domain//O-methyltransferase GO:0000162//GO:0006571//GO:0006094//GO:0009094//GO:0006096 tryptophan biosynthetic process//tyrosine biosynthetic process//gluconeogenesis//L-phenylalanine biosynthetic process//glycolytic process GO:0000287//GO:0004634//GO:0008171 magnesium ion binding//phosphopyruvate hydratase activity//O-methyltransferase activity GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-1454.0 BP_3 5.00 0.43 849 676488135 XP_009064521.1 302 5.3e-25 hypothetical protein LOTGIDRAFT_168383 [Lottia gigantea]>gi|556096067|gb|ESO84719.1| hypothetical protein LOTGIDRAFT_168383 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14540.0 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14544.0 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14544.1 BP_3 11.00 0.36 1753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14545.0 BP_3 7.00 0.31 1376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14551.0 BP_3 6.00 0.37 1072 642938969 XP_008191638.1 493 4.7e-47 PREDICTED: uncharacterized protein LOC661485 isoform X5 [Tribolium castaneum]>gi|642938971|ref|XP_008191639.1| PREDICTED: uncharacterized protein LOC661485 isoform X5 [Tribolium castaneum] 298493473 GU182882.1 226 1.10876e-112 Scylla paramamosain microsatellite Scpa02 sequence -- -- -- -- Q8N2Y8 319 2.9e-28 Iporin OS=Homo sapiens GN=RUSC2 PE=1 SV=3 PF14999//PF15337 Shadow of prion protein, neuroprotective//Vascular protein family Vasculin-like 1 GO:0006351//GO:0045893 transcription, DNA-templated//positive regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0031225//GO:0005667 nucleus//anchored component of membrane//transcription factor complex -- -- Cluster-14554.0 BP_3 2.00 0.31 599 646720247 KDR22067.1 517 4.4e-50 FERM domain-containing protein 8 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q0IJ35 317 2.8e-28 FERM domain-containing protein 8 OS=Xenopus tropicalis GN=frmd8 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4335 FERM domain-containing protein KRIT1 Cluster-14568.1 BP_3 3.00 0.31 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14584.0 BP_3 3.00 0.59 535 262400983 ACY66394.1 371 3.3e-33 metallothionein [Scylla paramamosain] 262400982 FJ774671.1 501 0 Scylla paramamosain metallothionein mRNA, complete cds -- -- -- -- P02806 146 1.7e-08 Metallothionein-2 OS=Scylla serrata PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-14588.0 BP_3 27.81 0.66 2322 556767709 XP_005979086.1 2127 3.5e-236 PREDICTED: probable phosphoketolase-like [Pantholops hodgsonii] 768311758 CP010986.1 2319 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- Q8DJN6 2544 6.3e-286 Probable phosphoketolase OS=Thermosynechococcus elongatus (strain BP-1) GN=tll1186 PE=3 SV=1 PF02083//PF03894//PF09363 Urotensin II//D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase//XFP C-terminal domain GO:0005975//GO:0008217//GO:0042312//GO:0007165 carbohydrate metabolic process//regulation of blood pressure//regulation of vasodilation//signal transduction GO:0005179//GO:0016832 hormone activity//aldehyde-lyase activity GO:0005576 extracellular region -- -- Cluster-14594.0 BP_3 14.00 2.07 617 732554603 AIZ72682.1 449 3.4e-42 c-type lysozyme 4 [Harmonia axyridis] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 Q17005 283 2.5e-24 Lysozyme c-1 OS=Anopheles gambiae GN=AGAP007347 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-14596.1 BP_3 7.51 0.40 1190 642919143 XP_008191755.1 1237 2.8e-133 PREDICTED: dynein heavy chain 1, axonemal-like [Tribolium castaneum] 826464598 XM_012679436.1 83 3.84014e-33 PREDICTED: Monomorium pharaonis dynein heavy chain 7, axonemal-like (LOC105835843), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q9P2D7 1010 2.4e-108 Dynein heavy chain 1, axonemal OS=Homo sapiens GN=DNAH1 PE=2 SV=4 PF07728//PF00437//PF00270 AAA domain (dynein-related subfamily)//Type II/IV secretion system protein//DEAD/DEAH box helicase GO:0006810 transport GO:0005524//GO:0003676//GO:0016887 ATP binding//nucleic acid binding//ATPase activity -- -- -- -- Cluster-14599.0 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-146.0 BP_3 2.00 0.90 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14601.0 BP_3 5.69 0.66 707 189238817 XP_967438.2 345 4.5e-30 PREDICTED: uncharacterized protein LOC655783 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14604.0 BP_3 5.00 0.31 1063 642916652 XP_008192045.1 1531 2.0e-167 PREDICTED: serine/threonine-protein kinase N isoform X1 [Tribolium castaneum]>gi|642916654|ref|XP_008192052.1| PREDICTED: serine/threonine-protein kinase N isoform X1 [Tribolium castaneum]>gi|642916656|ref|XP_008192057.1| PREDICTED: serine/threonine-protein kinase N isoform X1 [Tribolium castaneum] 241741185 XM_002412330.1 314 1.32472e-161 Ixodes scapularis protein kinase, putative, mRNA K06071 PKN protein kinase N http://www.genome.jp/dbget-bin/www_bget?ko:K06071 A1Z7T0 1479 9.0e-163 Serine/threonine-protein kinase N OS=Drosophila melanogaster GN=Pkn PE=1 SV=1 PF00433//PF07714//PF00069 Protein kinase C terminal domain//Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0694 Serine/threonine protein kinase Cluster-14610.0 BP_3 3.00 0.32 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14614.0 BP_3 2.00 0.35 569 754352026 XP_004343524.2 495 1.5e-47 K+ channel protein [Capsaspora owczarzaki ATCC 30864]>gi|765556898|gb|KJE97207.1| K+ channel protein [Capsaspora owczarzaki ATCC 30864] 768311759 CP010987.1 566 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence K04882 KCNAB1 potassium voltage-gated channel Shaker-related subfamily A, beta member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04882 O59826 555 6.7e-56 Putative voltage-gated potassium channel subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC965.06 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1575 Voltage-gated shaker-like K+ channel, subunit beta/KCNAB Cluster-14622.0 BP_3 5.00 0.34 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00747 ssDNA binding protein GO:0006260 DNA replication GO:0003697 single-stranded DNA binding GO:0042025 host cell nucleus -- -- Cluster-14624.1 BP_3 2.00 0.62 447 817283196 XP_012311798.1 135 6.4e-06 PREDICTED: LOW QUALITY PROTEIN: ras-related protein Rab-6C-like [Aotus nancymaae] 194387535 AK297792.1 447 0 Homo sapiens cDNA FLJ51902 complete cds, highly similar to ADP-ribosylation factor 1 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14625.0 BP_3 2.00 0.56 464 861615424 KMQ86103.1 316 6.8e-27 retrovirus-related pol polyprotein from transposon tnt 1-94 [Lasius niger] 404312713 AC253540.1 392 0 Prunus persica clone JGIBIXB-13K9, complete sequence -- -- -- -- P10978 323 4.3e-29 Retrovirus-related Pol polyprotein from transposon TNT 1-94 OS=Nicotiana tabacum PE=2 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-14628.0 BP_3 2.00 0.53 474 657587483 XP_008298035.1 280 1.0e-22 PREDICTED: fibrocystin-L [Stegastes partitus] -- -- -- -- -- -- -- -- -- Q86WI1 185 4.5e-13 Fibrocystin-L OS=Homo sapiens GN=PKHD1L1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-14632.0 BP_3 3.00 0.74 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140//PF05162 Crustacean cuticle protein repeat//Ribosomal protein L41 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0042302//GO:0003735 structural constituent of cuticle//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-14640.0 BP_3 3.00 0.41 644 686772281 XP_009234821.1 209 2.4e-14 PREDICTED: LOW QUALITY PROTEIN: basic salivary proline-rich protein 1-like, partial [Pongo abelii] 656985044 NM_001293698.1 644 0 Homo sapiens septin 9 (SEPT9), transcript variant 11, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14644.0 BP_3 2.00 0.70 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14645.0 BP_3 6.00 0.69 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14646.0 BP_3 2.00 0.35 568 194741490 XP_001953222.1 300 6.0e-25 GF17660 [Drosophila ananassae]>gi|190626281|gb|EDV41805.1| GF17660 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- Q9VI75 289 4.6e-25 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF07651//PF00777 ANTH domain//Glycosyltransferase family 29 (sialyltransferase) GO:0006486 protein glycosylation GO:0008373//GO:0005543 sialyltransferase activity//phospholipid binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-14652.0 BP_3 2.00 0.81 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14655.0 BP_3 15.00 1.14 926 347970384 XP_003436564.1 359 1.4e-31 AGAP013100-PA [Anopheles gambiae str. PEST]>gi|333468908|gb|EGK97106.1| AGAP013100-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08091 Spider insecticidal peptide GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-14659.0 BP_3 2.00 0.59 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1466.0 BP_3 9.00 1.12 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14660.0 BP_3 6.00 0.31 1224 -- -- -- -- -- 768311759 CP010987.1 1209 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- PF00175//PF08030//PF08022 Oxidoreductase NAD-binding domain//Ferric reductase NAD binding domain//FAD-binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-14671.0 BP_3 2.00 1.30 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14674.0 BP_3 2.00 0.93 394 297294711 XP_002804494.1 407 1.6e-37 PREDICTED: hypothetical protein LOC698789 [Macaca mulatta] 675780847 XM_003824939.2 394 0 PREDICTED: Pan paniscus ribosomal protein L41 (RPL41), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14681.0 BP_3 2.00 0.42 523 -- -- -- -- -- 768311754 CP010982.1 517 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- Q92396 147 1.3e-08 Tyrosinase OS=Podospora anserina GN=TYR PE=2 SV=1 PF00264 Common central domain of tyrosinase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-14688.0 BP_3 3.00 1.52 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1469.0 BP_3 37.90 2.00 1204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14690.0 BP_3 2.00 0.57 462 -- -- -- -- -- 768311753 CP010981.1 459 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14694.0 BP_3 1.00 0.64 363 242010839 XP_002426166.1 331 9.7e-29 Early growth response protein, putative [Pediculus humanus corporis]>gi|212510213|gb|EEB13428.1| Early growth response protein, putative [Pediculus humanus corporis] 347968525 XM_312150.5 115 1.78587e-51 Anopheles gambiae str. PEST AGAP002773-PA (AgaP_AGAP002773) mRNA, complete cds K12497 EGR3 early growth response protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12497 P43300 199 8.1e-15 Early growth response protein 3 OS=Mus musculus GN=Egr3 PE=2 SV=2 PF13465 Zinc-finger double domain -- -- GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0005622 intracellular KOG1721 FOG: Zn-finger Cluster-14697.0 BP_3 7.00 0.37 1214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14701.0 BP_3 3.00 0.41 644 90081888 BAE90225.1 226 2.6e-16 unnamed protein product [Macaca fascicularis] 133778979 NM_001005354.2 644 0 Homo sapiens proline rich 13 (PRR13), transcript variant 3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14704.0 BP_3 4.00 0.52 660 765826452 NP_001292307.1 269 2.7e-21 uncharacterized protein LOC105344505 precursor [Crassostrea gigas]>gi|148717305|dbj|BAF63638.1| calnexin [Crassostrea gigas] 697067368 XM_009650574.1 494 0 Verticillium dahliae VdLs.17 calnexin partial mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 Q6Q487 544 1.5e-54 Calnexin homolog OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=AFUA_4G12850 PE=2 SV=2 PF00262 Calreticulin family GO:0006457 protein folding GO:0005509//GO:0051082 calcium ion binding//unfolded protein binding GO:0005783 endoplasmic reticulum KOG0675 Calnexin Cluster-14706.0 BP_3 8.00 0.32 1486 749165791 XP_011134524.1 603 1.2e-59 mannitol-1-phosphate 5-dehydrogenase [Gregarina niphandrodes]>gi|608675826|gb|EZG68900.1| mannitol-1-phosphate 5-dehydrogenase [Gregarina niphandrodes] 697070740 XM_009652151.1 1456 0 Verticillium dahliae VdLs.17 mannitol-1-phosphate 5-dehydrogenase mRNA -- -- -- -- Q7SA44 1538 1.8e-169 Mannitol-1-phosphate 5-dehydrogenase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=NCU07318 PE=3 SV=1 PF01232//PF08125//PF02558 Mannitol dehydrogenase Rossmann domain//Mannitol dehydrogenase C-terminal domain//Ketopantoate reductase PanE/ApbA GO:0055114//GO:0015940 oxidation-reduction process//pantothenate biosynthetic process GO:0016491//GO:0050662//GO:0008677 oxidoreductase activity//coenzyme binding//2-dehydropantoate 2-reductase activity -- -- -- -- Cluster-14717.0 BP_3 3.00 0.36 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14718.0 BP_3 18.00 0.60 1749 821033957 XP_012353756.1 2236 6.0e-249 PREDICTED: alpha-enolase isoform X1 [Nomascus leucogenys] 346708295 AK378450.1 1749 0 Bombyx mori mRNA, clone: fmgV43K17 K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 P06733 2224 6.1e-249 Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 PF00113//PF03952 Enolase, C-terminal TIM barrel domain//Enolase, N-terminal domain GO:0006096//GO:0009094//GO:0006094//GO:0006571//GO:0000162 glycolytic process//L-phenylalanine biosynthetic process//gluconeogenesis//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0004634//GO:0000287 phosphopyruvate hydratase activity//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-14721.0 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14724.0 BP_3 2.00 0.99 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14732.0 BP_3 9.00 1.20 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14741.0 BP_3 2.00 1.29 363 544518890 XP_005592783.1 352 3.6e-31 PREDICTED: 60S ribosomal protein L39-like [Macaca fascicularis] 459642361 NM_001000.3 363 0 Homo sapiens ribosomal protein L39 (RPL39), mRNA K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 P62892 275 1.3e-23 60S ribosomal protein L39 OS=Mus musculus GN=Rpl39 PE=3 SV=2 PF00832 Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0002 60s ribosomal protein L39 Cluster-14749.0 BP_3 40.09 1.85 1337 642937929 XP_008199135.1 1029 4.2e-109 PREDICTED: doublesex- and mab-3-related transcription factor A2-like [Tribolium castaneum]>gi|270015667|gb|EFA12115.1| hypothetical protein TcasGA2_TC002261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q801F8 244 1.8e-19 Doublesex- and mab-3-related transcription factor 1 OS=Oryzias latipes GN=dmrt1 PE=2 SV=1 PF00751 DM DNA binding domain GO:0007548//GO:0006355 sex differentiation//regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding GO:0005634 nucleus KOG3815 Transcription factor Doublesex Cluster-1476.0 BP_3 12.00 0.84 977 270001339 EEZ97786.1 240 9.4e-18 odorant receptor 309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949//PF08395 7tm Odorant receptor//7tm Chemosensory receptor GO:0007608//GO:0050909//GO:0007187 sensory perception of smell//sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-14761.0 BP_3 12.00 0.34 1994 641659246 XP_008181021.1 305 5.6e-25 PREDICTED: uncharacterized protein LOC103308774 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115 SFI toxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-14765.0 BP_3 3.00 0.46 608 768445483 XP_011564645.1 488 1.0e-46 PREDICTED: uncharacterized protein LOC105394441 isoform X1 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14769.0 BP_3 6.00 0.39 1042 546685928 ERL95347.1 1084 1.4e-115 hypothetical protein D910_12612 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R3P7 443 1.2e-42 Clusterin-associated protein 1 OS=Mus musculus GN=Cluap1 PE=1 SV=1 PF03938//PF04111//PF04799//PF10417//PF16752//PF04513//PF06657 Outer membrane protein (OmpH-like)//Autophagy protein Apg6//fzo-like conserved region//C-terminal domain of 1-Cys peroxiredoxin//Tubulin-specific chaperone C N-terminal domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Centrosome microtubule-binding domain of Cep57 GO:0008053//GO:0055114//GO:0006914 mitochondrial fusion//oxidation-reduction process//autophagy GO:0051082//GO:0008017//GO:0051920//GO:0005198//GO:0015631//GO:0003924 unfolded protein binding//microtubule binding//peroxiredoxin activity//structural molecule activity//tubulin binding//GTPase activity GO:0005741//GO:0019028//GO:0016021//GO:0019031//GO:0045298 mitochondrial outer membrane//viral capsid//integral component of membrane//viral envelope//tubulin complex KOG3647 Predicted coiled-coil protein Cluster-14770.0 BP_3 2.00 0.34 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14774.0 BP_3 7.00 0.33 1314 478260362 ENN80109.1 794 7.3e-82 hypothetical protein YQE_03468, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14775.0 BP_3 3.00 0.89 453 641667845 XP_008184241.1 286 2.0e-23 PREDICTED: spidroin-2-like isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF01674 Chitin binding Peritrophin-A domain//Lipase (class 2) GO:0006030 chitin metabolic process GO:0016787//GO:0008061 hydrolase activity//chitin binding GO:0005576 extracellular region -- -- Cluster-14776.0 BP_3 2.00 0.44 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14778.0 BP_3 1.00 0.61 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14782.0 BP_3 2.00 0.55 468 -- -- -- -- -- 768311753 CP010981.1 355 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1479.0 BP_3 3.00 0.95 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14790.0 BP_3 12.00 1.72 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14792.0 BP_3 3.00 0.86 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14799.0 BP_3 4.00 0.32 899 674267117 CDI97505.1 228 2.1e-16 eukaryotic translation initiation factor 3 [Echinococcus multilocularis] 697090328 XM_009659775.1 899 0 Verticillium dahliae VdLs.17 eukaryotic translation initiation factor 3 subunit 8 partial mRNA K03252 EIF3C translation initiation factor 3 subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K03252 A7E471 824 6.8e-87 Eukaryotic translation initiation factor 3 subunit C OS=Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) GN=nip1 PE=3 SV=1 PF07851//PF05470//PF01496 TMPIT-like protein//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//V-type ATPase 116kDa subunit family GO:0006446//GO:0015991//GO:0006413//GO:0015992 regulation of translational initiation//ATP hydrolysis coupled proton transport//translational initiation//proton transport GO:0003743//GO:0031369//GO:0015078 translation initiation factor activity//translation initiation factor binding//hydrogen ion transmembrane transporter activity GO:0016021//GO:0005840//GO:0005852//GO:0033179 integral component of membrane//ribosome//eukaryotic translation initiation factor 3 complex//proton-transporting V-type ATPase, V0 domain KOG1076 Translation initiation factor 3, subunit c (eIF-3c) Cluster-14801.0 BP_3 2.00 0.35 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14802.0 BP_3 18.00 0.46 2187 189237043 XP_001810887.1 2357 7.0e-263 PREDICTED: neuroligin-4, Y-linked [Tribolium castaneum] 752862434 XM_011264522.1 55 2.62858e-17 PREDICTED: Camponotus floridanus neuroligin-1-like (LOC105255303), mRNA -- -- -- -- Q99K10 483 5.7e-47 Neuroligin-1 OS=Mus musculus GN=Nlgn1 PE=1 SV=2 PF06112 Gammaherpesvirus capsid protein -- -- -- -- GO:0019028 viral capsid KOG1516 Carboxylesterase and related proteins Cluster-14805.0 BP_3 4.00 0.48 691 66812642 XP_640500.1 151 1.4e-07 ZIP zinc transporter protein [Dictyostelium discoideum AX4]>gi|60468516|gb|EAL66520.1| ZIP zinc transporter protein [Dictyostelium discoideum AX4] 667645562 XM_008596391.1 101 2.15438e-43 Beauveria bassiana ARSEF 2860 zinc/iron transporter protein partial mRNA -- -- -- -- Q0DHE3 173 1.6e-11 Zinc transporter 9 OS=Oryza sativa subsp. japonica GN=ZIP9 PE=3 SV=3 PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-14812.0 BP_3 0.63 0.44 357 642911511 XP_008199453.1 281 6.0e-23 PREDICTED: protein unc-79 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14814.0 BP_3 2.00 0.37 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1482.0 BP_3 3.00 0.38 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14820.0 BP_3 8.00 0.66 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14825.0 BP_3 2.00 0.36 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14827.0 BP_3 2.00 0.62 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14829.0 BP_3 6.00 0.39 1025 332380580 AEE65457.1 1182 5.8e-127 syntenin [Penaeus monodon] 332380579 HM210774.1 238 2.25918e-119 Penaeus monodon isolate YO3 syntenin mRNA, complete cds K17254 SDCBP syntenin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K17254 Q9JI92 735 1.6e-76 Syntenin-1 OS=Rattus norvegicus GN=Sdcbp PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-14832.0 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14834.0 BP_3 7.00 1.51 515 -- -- -- -- -- 697074661 XM_009653537.1 512 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- PF06657//PF12467 Centrosome microtubule-binding domain of Cep57//Cucumber mosaic virus 1a protein family -- -- GO:0008017//GO:0008168//GO:0016817 microtubule binding//methyltransferase activity//hydrolase activity, acting on acid anhydrides GO:0045298 tubulin complex -- -- Cluster-14840.0 BP_3 1.00 0.39 413 63099685 AAY32923.1 489 5.3e-47 prohibitin [Clonorchis sinensis] 697069412 XM_009651595.1 413 0 Verticillium dahliae VdLs.17 prohibitin partial mRNA K17080 PHB1 prohibitin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17080 P40961 550 1.8e-55 Prohibitin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHB1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3083 Prohibitin Cluster-14848.0 BP_3 1.00 0.64 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14857.1 BP_3 2.00 2.54 318 29134779 BAC66140.1 353 2.4e-31 projectin [Procambarus clarkii] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14864.0 BP_3 4.00 0.31 914 646715184 KDR18888.1 599 2.1e-59 Proclotting enzyme [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- B5U2W0 501 2.0e-49 Venom serine protease Bi-VSP OS=Bombus ignitus PE=1 SV=1 PF00089//PF01829 Trypsin//Peptidase A6 family GO:0006508 proteolysis GO:0004190//GO:0004252 aspartic-type endopeptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-14869.1 BP_3 4.00 0.37 809 -- -- -- -- -- 768311754 CP010982.1 790 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14870.0 BP_3 4.00 0.47 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-14873.0 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14885.0 BP_3 4.00 0.34 851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14889.0 BP_3 1.00 1.65 305 646703159 KDR11975.1 184 9.1e-12 Up-regulated during skeletal muscle growth protein 5 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9JJW3 125 2.6e-06 Up-regulated during skeletal muscle growth protein 5 OS=Rattus norvegicus GN=Usmg5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-1489.0 BP_3 2.00 0.44 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14899.0 BP_3 2.00 0.74 422 260833738 XP_002611869.1 408 1.3e-37 hypothetical protein BRAFLDRAFT_59218 [Branchiostoma floridae]>gi|322518338|sp|C3XVT5.1|LIS1_BRAFL RecName: Full=Lissencephaly-1 homolog [Branchiostoma floridae]>gi|229297241|gb|EEN67878.1| hypothetical protein BRAFLDRAFT_59218 [Branchiostoma floridae] -- -- -- -- -- K16794 PAFAH1B1, LIS1 platelet-activating factor acetylhydrolase IB subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16794 C3XVT5 408 5.5e-39 Lissencephaly-1 homolog OS=Branchiostoma floridae GN=BRAFLDRAFT_59218 PE=3 SV=1 PF00400 WD domain, G-beta repeat GO:0051301//GO:0007067//GO:0006810 cell division//mitotic nuclear division//transport GO:0005515 protein binding GO:0005815//GO:0005737//GO:0005874 microtubule organizing center//cytoplasm//microtubule KOG0292 Vesicle coat complex COPI, alpha subunit Cluster-149.0 BP_3 4.00 0.49 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14900.0 BP_3 10.00 0.37 1612 167518822 XP_001743751.1 1693 5.1e-186 hypothetical protein [Monosiga brevicollis MX1]>gi|163777713|gb|EDQ91329.1| predicted protein [Monosiga brevicollis MX1] 697067940 XM_009650860.1 1408 0 Verticillium dahliae VdLs.17 6-phosphogluconate dehydrogenase partial mRNA K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00033 P38720 1839 2.5e-204 6-phosphogluconate dehydrogenase, decarboxylating 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GND1 PE=1 SV=1 PF00393//PF00162//PF14833//PF03446 6-phosphogluconate dehydrogenase, C-terminal domain//Phosphoglycerate kinase//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006098//GO:0006096//GO:0016310//GO:0019521//GO:0015976//GO:0006094//GO:0055114 pentose-phosphate shunt//glycolytic process//phosphorylation//D-gluconate metabolic process//carbon utilization//gluconeogenesis//oxidation-reduction process GO:0050661//GO:0050662//GO:0016616//GO:0004618//GO:0051287//GO:0004616//GO:0000166 NADP binding//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphoglycerate kinase activity//NAD binding//phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding -- -- KOG2653 6-phosphogluconate dehydrogenase Cluster-14901.0 BP_3 14.77 1.06 961 685828771 CEF63693.1 166 3.5e-09 6-phosphofructokinase [Strongyloides ratti] -- -- -- -- -- K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 Q9TZL8 165 1.9e-10 ATP-dependent 6-phosphofructokinase 1 OS=Caenorhabditis elegans GN=pfk-1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-14902.0 BP_3 5.00 1.60 442 501298210 BAN21304.1 217 2.0e-15 unkown protein [Riptortus pedestris] -- -- -- -- -- K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P80432 146 1.4e-08 Cytochrome c oxidase subunit 7C, mitochondrial OS=Rattus norvegicus GN=Cox7c PE=1 SV=2 PF02935 Cytochrome c oxidase subunit VIIc GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-14909.0 BP_3 4.13 0.71 572 645015704 XP_008211166.1 162 6.1e-09 PREDICTED: cytochrome P450 4AB4 isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-14920.0 BP_3 3.00 0.42 632 530660275 XP_005315177.1 318 5.5e-27 PREDICTED: uncharacterized protein LOC101933223 [Chrysemys picta bellii] 46518552 AC113334.2 611 0 Oryza sativa Japonica Group chromosome 5 clone OJ1123_F01, complete sequence -- -- -- -- -- -- -- -- PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-14928.0 BP_3 15.00 0.52 1685 675385960 KFM78857.1 846 8.7e-88 Serine/threonine-protein kinase pim-3, partial [Stegodyphus mimosarum] 262401344 FJ774854.1 305 2.1386e-156 Scylla paramamosain hypothetical protein mRNA, partial cds K08807 PIM3 proto-oncogene serine/threonine-protein kinase Pim-3 http://www.genome.jp/dbget-bin/www_bget?ko:K08807 Q9PU85 799 1.0e-83 Serine/threonine-protein kinase pim-3 OS=Coturnix coturnix japonica GN=PIM3 PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-14932.0 BP_3 3.00 0.34 721 332375432 AEE62857.1 738 1.2e-75 unknown [Dendroctonus ponderosae]>gi|546681108|gb|ERL91264.1| hypothetical protein D910_08598 [Dendroctonus ponderosae] -- -- -- -- -- K14410 ACP2 lysosomal acid phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14410 Q5BLY5 442 1.1e-42 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-14934.0 BP_3 5.00 0.95 546 -- -- -- -- -- 768311753 CP010981.1 543 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14944.0 BP_3 1.00 0.32 441 662216158 XP_008481995.1 234 2.1e-17 PREDICTED: uncharacterized protein LOC103518694 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14945.0 BP_3 18.00 0.52 1948 514698740 XP_004996939.1 1656 1.2e-181 transketolase [Salpingoeca rosetta]>gi|326436165|gb|EGD81735.1| transketolase [Salpingoeca rosetta] 697069478 XM_009651628.1 1823 0 Verticillium dahliae VdLs.17 transketolase partial mRNA -- -- -- -- P34736 2103 7.2e-235 Transketolase OS=Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) GN=TKT PE=3 SV=2 PF13292//PF02780 1-deoxy-D-xylulose-5-phosphate synthase//Transketolase, C-terminal domain GO:0008152//GO:0016114//GO:0006694 metabolic process//terpenoid biosynthetic process//steroid biosynthetic process GO:0003824//GO:0008661 catalytic activity//1-deoxy-D-xylulose-5-phosphate synthase activity -- -- KOG0523 Transketolase Cluster-14957.0 BP_3 4.00 1.21 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14959.0 BP_3 11.00 0.95 851 -- -- -- -- -- 697073825 XM_009653239.1 618 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF01097 Arthropod defensin GO:0006952 defense response -- -- -- -- -- -- Cluster-14961.0 BP_3 3.00 0.82 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14963.0 BP_3 9.36 0.33 1649 642924044 XP_008193983.1 876 2.8e-91 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q5R3Z8 625 1.5e-63 F-box/LRR-repeat protein 2 OS=Pongo abelii GN=FBXL2 PE=2 SV=1 PF00560//PF13516//PF13855//PF02126 Leucine Rich Repeat//Leucine Rich repeat//Leucine rich repeat//Phosphotriesterase family GO:0009056 catabolic process GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG4341 F-box protein containing LRR Cluster-14965.0 BP_3 3.79 3.83 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14966.1 BP_3 4.00 0.47 704 675381363 KFM74265.1 672 5.5e-68 Eukaryotic elongation factor 2 kinase, partial [Stegodyphus mimosarum] -- -- -- -- -- K08292 EEF2K elongation factor 2 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08292 O08796 596 1.5e-60 Eukaryotic elongation factor 2 kinase OS=Mus musculus GN=Eef2k PE=1 SV=1 PF02816 Alpha-kinase family GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004674//GO:0005524 protein serine/threonine kinase activity//ATP binding -- -- -- -- Cluster-14983.0 BP_3 2.00 0.43 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14990.1 BP_3 4.00 0.61 609 56090150 NP_001007766.1 462 1.1e-43 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [Danio rerio]>gi|55716039|gb|AAH85651.1| NADH dehydrogenase (ubiquinone) Fe-S protein 1 [Danio rerio] 697083826 XM_009656692.1 594 0 Verticillium dahliae VdLs.17 NADH-ubiquinone oxidoreductase 78 kDa subunit partial mRNA K03934 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03934 P24918 879 1.9e-93 NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=nuo78 PE=1 SV=2 PF00384//PF09326 Molybdopterin oxidoreductase//NADH-ubiquinone oxidoreductase subunit G, C-terminal GO:0055114//GO:0045333 oxidation-reduction process//cellular respiration GO:0016491//GO:0016651//GO:0051536 oxidoreductase activity//oxidoreductase activity, acting on NAD(P)H//iron-sulfur cluster binding GO:0016020 membrane KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit Cluster-14993.0 BP_3 5.00 1.29 478 -- -- -- -- -- 768311752 CP010980.1 460 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15.0 BP_3 29.00 25.44 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06403 Lamprin -- -- GO:0005198 structural molecule activity GO:0005578 proteinaceous extracellular matrix -- -- Cluster-15004.0 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15007.0 BP_3 6.00 0.36 1088 641652738 XP_008178518.1 292 9.8e-24 PREDICTED: craniofacial development protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-15008.0 BP_3 12.00 1.58 657 307214316 EFN89400.1 457 4.3e-43 hypothetical protein EAI_07694, partial [Harpegnathos saltator] 795019206 XM_012004108.1 45 2.75723e-12 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556990 (LOC105556990), mRNA -- -- -- -- -- -- -- -- PF13404 AsnC-type helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-15017.0 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15028.0 BP_3 3.00 0.40 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15030.0 BP_3 2.00 0.38 543 470505855 XP_004348674.1 255 9.5e-20 glutamate decarboxylase [Acanthamoeba castellanii str. Neff]>gi|440801136|gb|ELR22160.1| glutamate decarboxylase [Acanthamoeba castellanii str. Neff] 768311758 CP010986.1 537 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- Q04792 319 1.5e-28 Glutamate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAD1 PE=1 SV=1 PF00282 Pyridoxal-dependent decarboxylase conserved domain GO:0019752 carboxylic acid metabolic process GO:0030170//GO:0016831 pyridoxal phosphate binding//carboxy-lyase activity -- -- -- -- Cluster-15033.0 BP_3 2.00 0.58 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15035.0 BP_3 2.00 0.49 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15036.0 BP_3 1.00 0.80 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15039.0 BP_3 6.00 0.34 1147 501297758 BAN21224.1 549 1.6e-53 succinyl-coa synthetase beta chain [Riptortus pedestris] 689902486 LM383548.1 77 8.01269e-30 Hymenolepis diminuta genome assembly H_diminuta_Denmark ,scaffold HDID_scaffold0000088 K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 P53588 540 7.4e-54 Probable succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Caenorhabditis elegans GN=F47B10.1 PE=3 SV=1 PF03709//PF00549 Orn/Lys/Arg decarboxylase, N-terminal domain//CoA-ligase GO:0008152 metabolic process GO:0003824//GO:0016831 catalytic activity//carboxy-lyase activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-15040.0 BP_3 15.00 1.04 988 156401458 XP_001639308.1 716 6.1e-73 predicted protein [Nematostella vectensis]>gi|156226435|gb|EDO47245.1| predicted protein [Nematostella vectensis] 697082900 XM_009656371.1 786 0 Verticillium dahliae VdLs.17 60S ribosomal protein L8 partial mRNA K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 O13672 832 8.8e-88 60S ribosomal protein L8 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl8 PE=1 SV=3 PF05602 Cleft lip and palate transmembrane protein 1 (CLPTM1) -- -- -- -- GO:0016021 integral component of membrane KOG3166 60S ribosomal protein L7A Cluster-15050.0 BP_3 16.00 2.63 585 -- -- -- -- -- 403311088 JX457150.1 585 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15053.0 BP_3 6.00 0.39 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15057.0 BP_3 2.00 3.69 300 328796230 AEB40304.1 241 2.2e-18 mitochondrial ATP synthase epsilon subunit precursor [Litopenaeus vannamei] -- -- -- -- -- K02135 ATPeF1E, ATP5E, ATP15 F-type H+-transporting ATPase subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K02135 Q96253 135 1.8e-07 ATP synthase subunit epsilon, mitochondrial OS=Arabidopsis thaliana GN=At1g51650 PE=1 SV=3 PF04627 Mitochondrial ATP synthase epsilon chain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG3495 Mitochondrial F1F0-ATP synthase, subunit epsilon/ATP15 Cluster-15059.0 BP_3 4.00 0.53 657 242010956 XP_002426223.1 414 4.2e-38 mitochondrial import inner membrane translocase subunit Tim23, putative [Pediculus humanus corporis]>gi|212510286|gb|EEB13485.1| mitochondrial import inner membrane translocase subunit Tim23, putative [Pediculus humanus corporis] -- -- -- -- -- K17794 TIM23 mitochondrial import inner membrane translocase subunit TIM23 http://www.genome.jp/dbget-bin/www_bget?ko:K17794 Q5XH94 256 3.6e-21 Mitochondrial import inner membrane translocase subunit Tim23 OS=Xenopus tropicalis GN=timm23 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15062.0 BP_3 5.00 0.85 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15074.0 BP_3 1.00 0.83 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15085.0 BP_3 3.00 0.52 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15087.0 BP_3 5.00 0.54 740 242011349 XP_002426415.1 225 3.9e-16 ornithine carbamoyltransferase, putative [Pediculus humanus corporis]>gi|212510514|gb|EEB13677.1| ornithine carbamoyltransferase, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- P11725 184 9.1e-13 Ornithine carbamoyltransferase, mitochondrial OS=Mus musculus GN=Otc PE=1 SV=1 PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain GO:0006520 cellular amino acid metabolic process GO:0016743//GO:0016597 carboxyl- or carbamoyltransferase activity//amino acid binding -- -- -- -- Cluster-1509.0 BP_3 3.00 1.78 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15090.0 BP_3 5.00 0.57 714 397523210 XP_003831634.1 1159 1.9e-124 PREDICTED: LOW QUALITY PROTEIN: lymphotoxin-beta [Pan paniscus] 47481103 BC069330.1 714 0 Homo sapiens lymphotoxin beta (TNF superfamily, member 3), transcript variant 1, mRNA (cDNA clone MGC:97002 IMAGE:7262211), complete cds K03157 LTB, TNFC lymphotoxin beta (TNF superfamily, member 3) http://www.genome.jp/dbget-bin/www_bget?ko:K03157 Q06643 1164 2.0e-126 Lymphotoxin-beta OS=Homo sapiens GN=LTB PE=1 SV=1 PF00229 TNF(Tumour Necrosis Factor) family GO:0006955//GO:0007165 immune response//signal transduction GO:0005164 tumor necrosis factor receptor binding GO:0016020 membrane -- -- Cluster-15096.0 BP_3 4.00 0.62 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15098.0 BP_3 3.00 0.39 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1510.0 BP_3 3.00 0.35 703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15101.0 BP_3 4.00 0.34 852 668452364 KFB41317.1 530 1.9e-51 AGAP003644-PA-like protein [Anopheles sinensis] -- -- -- -- -- K02948 RP-S11, MRPS11, rpsK small subunit ribosomal protein S11 http://www.genome.jp/dbget-bin/www_bget?ko:K02948 Q9DCA2 299 4.8e-26 28S ribosomal protein S11, mitochondrial OS=Mus musculus GN=Mrps11 PE=2 SV=2 PF00411 Ribosomal protein S11 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0408 Mitochondrial/chloroplast ribosomal protein S11 Cluster-15102.0 BP_3 15.00 0.66 1383 -- -- -- -- -- 768311752 CP010980.1 918 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15106.0 BP_3 3.00 0.31 762 694529654 XP_009493653.1 260 3.5e-20 CAMKK/CAMKK-META protein kinase [Fonticula alba]>gi|627950251|gb|KCV72075.1| CAMKK/CAMKK-META protein kinase [Fonticula alba] 768311756 CP010984.1 759 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- P50526 388 2.1e-36 Serine/threonine-protein kinase ssp1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ssp1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-15109.0 BP_3 4.00 0.34 857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15111.0 BP_3 3.00 0.31 752 765549204 KJE89825.1 704 1.1e-71 biotin synthase [Capsaspora owczarzaki ATCC 30864] 697087225 XM_009658230.1 635 0 Verticillium dahliae VdLs.17 biotin synthase partial mRNA -- -- -- -- P54967 725 1.7e-75 Biotin synthase OS=Arabidopsis thaliana GN=BIO2 PE=2 SV=1 PF04055 Radical SAM superfamily -- -- GO:0051536//GO:0003824 iron-sulfur cluster binding//catalytic activity -- -- KOG2900 Biotin synthase Cluster-15117.0 BP_3 21.00 0.33 3320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00457 Glycosyl hydrolases family 11 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-15123.0 BP_3 2.00 0.65 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15125.0 BP_3 33.00 1.23 1590 642933218 XP_008197312.1 1230 2.4e-132 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12302 SLC17A6_7_8 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12302 O61369 758 5.4e-79 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF01004 Major Facilitator Superfamily//Flavivirus envelope glycoprotein M GO:0019058//GO:0055085 viral life cycle//transmembrane transport -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-15129.1 BP_3 2.00 0.39 541 646720358 KDR22116.1 660 1.0e-66 Plexin domain-containing protein 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6UX71 515 2.8e-51 Plexin domain-containing protein 2 OS=Homo sapiens GN=PLXDC2 PE=1 SV=1 PF06613 KorB C-terminal beta-barrel domain GO:0045892 negative regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3848 Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) Cluster-15135.0 BP_3 2.00 2.45 320 66392221 NP_001018164.1 156 1.7e-08 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C [Danio rerio]>gi|82228760|sp|Q502K3.1|ANR52_DANRE RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Short=PP6-ARS-C; Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C [Danio rerio]>gi|63101294|gb|AAH95664.1| Zgc:112069 [Danio rerio]>gi|182890066|gb|AAI65234.1| Zgc:112069 protein [Danio rerio] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q502K3 156 6.9e-10 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Danio rerio GN=ankrd52 PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-15141.0 BP_3 4.00 0.84 521 795018486 XP_011859227.1 221 8.0e-16 PREDICTED: uncharacterized protein LOC105556736 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225 helix-turn-helix, Psq domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-15155.1 BP_3 8.00 0.37 1345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15159.0 BP_3 14.00 0.94 1006 156386292 XP_001633847.1 785 6.1e-81 predicted protein [Nematostella vectensis]>gi|269969590|sp|A7S3J7.1|RS3A_NEMVE RecName: Full=40S ribosomal protein S3a>gi|156220922|gb|EDO41784.1| predicted protein [Nematostella vectensis] 697090984 XM_009660019.1 970 0 Verticillium dahliae VdLs.17 40S ribosomal protein S3a-2 mRNA K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 D4NXE7 1118 6.1e-121 40S ribosomal protein S1 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) GN=RPS1 PE=2 SV=2 PF01015//PF01253 Ribosomal S3Ae family//Translation initiation factor SUI1 GO:0006446//GO:0006412//GO:0042254//GO:0006413 regulation of translational initiation//translation//ribosome biogenesis//translational initiation GO:0003743//GO:0003735 translation initiation factor activity//structural constituent of ribosome GO:0005737//GO:0005840//GO:0030529//GO:0005622 cytoplasm//ribosome//intracellular ribonucleoprotein complex//intracellular KOG1628 40S ribosomal protein S3A Cluster-1516.0 BP_3 2.00 0.66 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15169.0 BP_3 5.00 0.37 942 642911198 XP_008199568.1 441 4.5e-41 PREDICTED: solute carrier family 12 member 4 isoform X2 [Tribolium castaneum] 734622526 XM_010740913.1 49 2.4015e-14 PREDICTED: Larimichthys crocea solute carrier family 12 (potassium/chloride transporter), member 4 (slc12a4), mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q9UHW9 341 7.2e-31 Solute carrier family 12 member 6 OS=Homo sapiens GN=SLC12A6 PE=1 SV=2 PF03522 Solute carrier family 12 GO:0006811//GO:0006810 ion transport//transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-1517.0 BP_3 7.00 0.36 1234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15180.0 BP_3 1.00 0.32 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15182.0 BP_3 1.00 0.47 393 25229108 AAN74647.1 221 6.0e-16 chitinase [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-15186.0 BP_3 6.00 0.52 852 588318453 CCW62640.1 232 6.9e-17 unnamed protein product [Phytomonas sp. isolate EM1]>gi|588318733|emb|CCW62027.1| unnamed protein product [Phytomonas sp. isolate EM1] 768311758 CP010986.1 708 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P51414 233 2.2e-18 60S ribosomal protein L26-1 OS=Arabidopsis thaliana GN=RPL26A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3401 60S ribosomal protein L26 Cluster-1519.0 BP_3 3.00 7.96 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15191.0 BP_3 19.00 1.78 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15196.0 BP_3 8.00 0.52 1037 470439159 XP_004339154.1 274 1.1e-21 GPR1/FUN34/yaaH family protein [Acanthamoeba castellanii str. Neff]>gi|440796032|gb|ELR17141.1| GPR1/FUN34/yaaH family protein [Acanthamoeba castellanii str. Neff] 697088872 XM_009659051.1 912 0 Verticillium dahliae VdLs.17 GPR1/FUN34/yaaH family protein partial mRNA -- -- -- -- Q5B2K4 706 3.8e-73 Acetate permease A OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=acpA PE=2 SV=1 PF01184//PF00288 GPR1/FUN34/yaaH family//GHMP kinases N terminal domain -- -- GO:0005524 ATP binding GO:0016021 integral component of membrane -- -- Cluster-15197.1 BP_3 5.00 0.46 812 847099547 XP_012812277.1 837 4.6e-87 PREDICTED: 14-3-3 protein epsilon isoform X1 [Xenopus (Silurana) tropicalis] 697068022 XM_009650901.1 629 0 Verticillium dahliae VdLs.17 DNA damage checkpoint protein rad24 partial mRNA K06630 YWHAE 14-3-3 protein epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K06630 Q99002 1018 2.0e-109 14-3-3 protein homolog OS=Trichoderma harzianum PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-152.0 BP_3 10.00 3.18 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15209.1 BP_3 3.00 0.31 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15218.0 BP_3 18.35 0.46 2216 356483015 CCE46010.1 2247 4.0e-250 putative DEAD-box ATP-dependent RNA helicase [Cancer pagurus] 356483014 HE608876.1 1532 0 Cancer pagurus mRNA for putative DEAD-box ATP-dependent RNA helicase (ddx gene) K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q92841 1781 1.8e-197 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 PF00270//PF00210//PF04851 DEAD/DEAH box helicase//Ferritin-like domain//Type III restriction enzyme, res subunit GO:0006879 cellular iron ion homeostasis GO:0003676//GO:0003677//GO:0016787//GO:0005524//GO:0008199 nucleic acid binding//DNA binding//hydrolase activity//ATP binding//ferric iron binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-15219.0 BP_3 2.00 1.09 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15224.2 BP_3 5.00 0.58 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15225.1 BP_3 3.00 0.46 603 -- -- -- -- -- 53749261 AC145271.4 582 0 Oryza sativa Japonica Group chromosome 5 clone B1140B01, complete sequence -- -- -- -- -- -- -- -- PF04138 GtrA-like protein GO:0006810//GO:0000271 transport//polysaccharide biosynthetic process -- -- GO:0016021 integral component of membrane -- -- Cluster-15228.0 BP_3 2.00 0.35 564 356651196 AET34915.1 154 5.1e-08 heat shock protein 21 [Macrobrachium rosenbergii] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10717 Occlusion-derived virus envelope protein ODV-E18 -- -- -- -- GO:0019031 viral envelope -- -- Cluster-15228.1 BP_3 1.00 0.37 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15231.0 BP_3 5.00 0.43 854 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15236.0 BP_3 8.00 1.19 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1524.0 BP_3 3.00 0.78 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15241.0 BP_3 3.00 0.82 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15248.0 BP_3 3.00 0.41 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15250.0 BP_3 5.00 0.34 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15261.0 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15262.0 BP_3 1.00 0.41 407 -- -- -- -- -- 768311757 CP010985.1 190 4.1109e-93 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005743//GO:0005750 mitochondrial inner membrane//mitochondrial respiratory chain complex III -- -- Cluster-15266.0 BP_3 6.28 1.65 475 -- -- -- -- -- 768311752 CP010980.1 472 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- P22151 155 1.3e-09 Glucose-repressible gene protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=grg-1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-1528.0 BP_3 3.00 1.53 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15280.0 BP_3 7.35 0.42 1136 478253033 ENN73413.1 1234 6.0e-133 hypothetical protein YQE_09975, partial [Dendroctonus ponderosae] 542171599 XM_005467190.1 51 2.25312e-15 PREDICTED: Oreochromis niloticus ATP-binding cassette sub-family A member 1-like (LOC100699821), transcript variant X3, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 871 3.0e-92 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF12179//PF00005//PF13304 I-kappa-kinase-beta NEMO binding domain//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0008384//GO:0016887//GO:0005524 IkappaB kinase activity//ATPase activity//ATP binding GO:0008385 IkappaB kinase complex KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-15283.0 BP_3 4.68 0.66 634 91076370 XP_967715.1 366 1.5e-32 PREDICTED: ras-related protein Rab-27A [Tribolium castaneum]>gi|270002552|gb|EEZ98999.1| hypothetical protein TcasGA2_TC004860 [Tribolium castaneum] -- -- -- -- -- K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 P51159 301 2.1e-26 Ras-related protein Rab-27A OS=Homo sapiens GN=RAB27A PE=1 SV=3 PF08477//PF01926//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ras family//ADP-ribosylation factor family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525 GTP binding -- -- KOG0081 GTPase Rab27, small G protein superfamily Cluster-15287.0 BP_3 5.00 0.92 553 4506205 NP_002791.1 758 4.5e-78 proteasome subunit beta type-9 proprotein [Homo sapiens]>gi|417529|sp|P28065.2|PSB9_HUMAN RecName: Full=Proteasome subunit beta type-9; AltName: Full=Low molecular mass protein 2; AltName: Full=Macropain chain 7; AltName: Full=Multicatalytic endopeptidase complex chain 7; AltName: Full=Proteasome chain 7; AltName: Full=Proteasome subunit beta-1i; AltName: Full=Really interesting new gene 12 protein; Flags: Precursor>gi|34635|emb|CAA47024.1| LMP2 [Homo sapiens]>gi|34656|emb|CAA78700.1| MHC-encoded proteasome subunit gene [Homo sapiens]>gi|1054744|emb|CAA60784.1| LMP2 [Homo sapiens]>gi|41388830|gb|AAH65513.1| Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) [Homo sapiens]>gi|49456273|emb|CAG46457.1| PSMB9 [Homo sapiens]>gi|119624059|gb|EAX03654.1| proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2), isoform CRA_b [Homo sapiens]>gi|261860734|dbj|BAI46889.1| proteasome (prosome, macropain) subunit, beta type, 9 [synthetic construct]>gi|649102558|gb|AIC49506.1| PSMB9, partial [synthetic construct] 14250659 BC008795.1 550 0 Homo sapiens cDNA clone IMAGE:3626111, **** WARNING: chimeric clone **** >gnl|BL_ORD_ID|3303992 Homo sapiens cDNA clone IMAGE:3626664, **** WARNING: chimeric clone **** K02741 PSMB9, LMP2 20S proteasome subunit beta 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02741 P28065 758 1.9e-79 Proteasome subunit beta type-9 OS=Homo sapiens GN=PSMB9 PE=1 SV=2 PF00227 Proteasome subunit GO:0031145//GO:0000216//GO:0051436//GO:0010467//GO:0051603//GO:0042981//GO:0002479//GO:0006521//GO:0006977//GO:0000084//GO:0016071//GO:0019048//GO:0000209//GO:0051437 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process//obsolete M/G1 transition of mitotic cell cycle//negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle//gene expression//proteolysis involved in cellular protein catabolic process//regulation of apoptotic process//antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent//regulation of cellular amino acid metabolic process//DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest//mitotic S phase//mRNA metabolic process//modulation by virus of host morphology or physiology//protein polyubiquitination//positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0005515//GO:0004298 protein binding//threonine-type endopeptidase activity GO:0005829//GO:0005654//GO:0005839 cytosol//nucleoplasm//proteasome core complex KOG0174 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 Cluster-15289.0 BP_3 2.00 0.39 542 667257879 XP_008566364.1 282 7.0e-23 PREDICTED: apolipoprotein D isoform X1 [Galeopterus variegatus] -- -- -- -- -- K03098 APOD apolipoprotein D and lipocalin family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03098 P51910 275 1.9e-23 Apolipoprotein D OS=Mus musculus GN=Apod PE=2 SV=1 PF03973 Triabin GO:0030682 evasion or tolerance of host defense response -- -- -- -- KOG4824 Apolipoprotein D/Lipocalin Cluster-15294.1 BP_3 9.00 1.03 711 157690742 CAL69098.1 425 2.4e-39 TPA: putative 40S ribosomal protein S12 [Spadella cephaloptera] 697090702 XM_009659929.1 704 0 Verticillium dahliae VdLs.17 40S ribosomal protein S12 mRNA K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 O59936 603 2.3e-61 40S ribosomal protein S12 OS=Blumeria graminis f. sp. hordei GN=RPS12 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3406 40S ribosomal protein S12 Cluster-153.0 BP_3 4.00 1.29 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15305.0 BP_3 4.00 0.36 832 808874503 KKF23577.1 311 4.7e-26 Serine protease 27 [Larimichthys crocea] -- -- -- -- -- K01346 CELA2 pancreatic elastase II http://www.genome.jp/dbget-bin/www_bget?ko:K01346 P08217 280 7.6e-24 Chymotrypsin-like elastase family member 2A OS=Homo sapiens GN=CELA2A PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-15307.0 BP_3 3.00 0.38 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15313.1 BP_3 1.00 0.82 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15315.0 BP_3 3.00 0.97 441 -- -- -- -- -- 116310127 CR855175.1 411 0 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSIGBa0122F23, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15315.2 BP_3 1.00 0.48 390 -- -- -- -- -- 58652042 AP008245.2 365 0 Oryza sativa Japonica Group genomic DNA, chromosome 9, BAC clone:OSJNBb0013K10 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15315.4 BP_3 3.00 0.56 550 719749139 XP_010212325.1 165 2.6e-09 PREDICTED: uncharacterized protein LOC104567219, partial [Tinamus guttatus] 116309182 CR855079.1 514 0 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSIGBa0116O04, complete sequence -- -- -- -- -- -- -- -- PF13545 Crp-like helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-1532.0 BP_3 3.00 0.80 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1532.1 BP_3 1.00 0.65 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15327.0 BP_3 15.70 0.79 1255 642938493 XP_008198006.1 1130 7.6e-121 PREDICTED: nose resistant to fluoxetine protein 6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 360 6.0e-33 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF07694//PF01757 5TMR of 5TMR-LYT//Acyltransferase family GO:0000160//GO:0016310//GO:0071555 phosphorelay signal transduction system//phosphorylation//cell wall organization GO:0000155//GO:0004673//GO:0016747 phosphorelay sensor kinase activity//protein histidine kinase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex -- -- Cluster-15330.0 BP_3 3.00 0.56 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15334.0 BP_3 1.00 0.40 411 4502993 NP_001858.1 329 1.9e-28 cytochrome c oxidase subunit 7C, mitochondrial precursor [Homo sapiens]>gi|120952493|ref|NP_001073391.1| cytochrome c oxidase subunit 7C, mitochondrial precursor [Pan troglodytes]>gi|332224925|ref|XP_003261620.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial [Nomascus leucogenys]>gi|397504520|ref|XP_003822837.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial [Pan paniscus]>gi|426349408|ref|XP_004042297.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Gorilla gorilla gorilla]>gi|820976572|ref|XP_012360946.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial [Nomascus leucogenys]>gi|117127|sp|P15954.1|COX7C_HUMAN RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor>gi|38502871|sp|P60025.1|COX7C_PANTR RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor>gi|48427919|sp|P61638.1|COX7C_GORGO RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor>gi|48427920|sp|P61639.1|COX7C_PANPA RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor [Pan paniscus]>gi|30155|emb|CAA34559.1| unnamed protein product [Homo sapiens]>gi|3859872|gb|AAC73062.1| cytochrome c oxidase subunit VIIc precursor [Homo sapiens]>gi|12654365|gb|AAH01005.1| Cytochrome c oxidase subunit VIIc [Homo sapiens]>gi|13960114|gb|AAH07498.1| Cytochrome c oxidase subunit VIIc [Homo sapiens]>gi|19773463|dbj|BAB86871.1| cytochrome oxidase subunit VIIc [Pan troglodytes]>gi|19773467|dbj|BAB86872.1| cytochrome oxidase subunit VIIc [Pan paniscus]>gi|19773471|dbj|BAB86873.1| cytochrome oxidase subunit VIIc [Gorilla gorilla]>gi|30583035|gb|AAP35762.1| cytochrome c oxidase subunit VIIc [Homo sapiens]>gi|60656107|gb|AAX32617.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|60656109|gb|AAX32618.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|119616329|gb|EAW95923.1| cytochrome c oxidase subunit VIIc, isoform CRA_b [Homo sapiens]>gi|123980904|gb|ABM82281.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|123995721|gb|ABM85462.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|343960298|dbj|BAK64003.1| cytochrome c oxidase polypeptide VIIc, mitochondrial precursor [Pan troglodytes]>gi|649099321|gb|AIC48551.1| COX7C, partial [synthetic construct] 10439379 AK026505.1 411 0 Homo sapiens cDNA: FLJ22852 fis, clone KAT00780 K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P61638 329 7.7e-30 Cytochrome c oxidase subunit 7C, mitochondrial OS=Gorilla gorilla gorilla GN=COX7C PE=3 SV=1 PF02935 Cytochrome c oxidase subunit VIIc GO:0015992//GO:0006123//GO:0022904//GO:0044281 proton transport//mitochondrial electron transport, cytochrome c to oxygen//respiratory electron transport chain//small molecule metabolic process GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0016021//GO:0045277 mitochondrial inner membrane//integral component of membrane//respiratory chain complex IV -- -- Cluster-15341.0 BP_3 15.00 1.21 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15350.0 BP_3 7.00 0.42 1096 297276274 XP_002801140.1 371 6.8e-33 PREDICTED: hypothetical protein LOC100423470 [Macaca mulatta] 14424664 BC009353.1 1093 0 Homo sapiens immediate early response 2, mRNA (cDNA clone IMAGE:4297793), **** WARNING: chimeric clone **** -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15351.0 BP_3 2.00 0.41 529 675377463 KFM70365.1 234 2.5e-17 Chondroitin proteoglycan 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P29030 148 9.7e-09 Endochitinase OS=Brugia malayi PE=1 SV=1 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-15357.0 BP_3 5.00 0.33 1026 646701025 KDR10948.1 683 4.2e-69 Transforming growth factor-beta-induced protein ig-h3 [Zootermopsis nevadensis] 338224397 HM217842.1 67 2.58681e-24 Scylla paramamosain isolate 1 midline fasciclin mRNA, partial cds -- -- -- -- Q62009 330 1.5e-29 Periostin OS=Mus musculus GN=Postn PE=1 SV=2 PF16557 CUT1-like DNA-binding domain of SATB -- -- GO:0003677 DNA binding -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-15362.0 BP_3 8.00 0.98 686 262401235 ACY66520.1 577 5.5e-57 hypothetical protein [Scylla paramamosain] 262401234 FJ774799.1 468 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15366.2 BP_3 2.00 0.66 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15369.0 BP_3 2.00 0.54 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04647 Accessory gene regulator B GO:0009405//GO:0009372 pathogenesis//quorum sensing GO:0008233 peptidase activity GO:0016021 integral component of membrane -- -- Cluster-15372.0 BP_3 2.00 0.49 488 321457352 EFX68440.1 630 2.8e-63 hypothetical protein DAPPUDRAFT_203278 [Daphnia pulex] -- -- -- -- -- K05034 SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA) member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05034 Q9VR07 549 2.8e-55 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-15376.0 BP_3 1.00 0.32 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15379.0 BP_3 22.61 0.53 2361 642936327 XP_969357.3 1314 6.6e-142 PREDICTED: hemicentin-2-like isoform X1 [Tribolium castaneum] 642936326 XM_964264.3 365 0 PREDICTED: Tribolium castaneum hemicentin-2-like (LOC657829), transcript variant X1, mRNA -- -- -- -- Q62718 136 1.1e-06 Neurotrimin OS=Rattus norvegicus GN=Ntm PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-15384.2 BP_3 1.00 0.39 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15385.0 BP_3 11.00 3.59 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-15389.0 BP_3 25.00 1.35 1185 675380433 KFM73335.1 414 7.6e-38 40S ribosomal protein S27, partial [Stegodyphus mimosarum] 850303920 XM_004709855.2 91 1.36549e-37 PREDICTED: Echinops telfairi 40S ribosomal protein S27-like (LOC101643953), mRNA K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 P55833 444 1.0e-42 40S ribosomal protein S27 OS=Homarus americanus GN=RPS27 PE=3 SV=2 PF01667 Ribosomal protein S27 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1779 40s ribosomal protein S27 Cluster-1539.0 BP_3 1.00 0.43 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15391.0 BP_3 33.92 0.69 2659 642910370 XP_008200295.1 2510 1.5e-280 PREDICTED: kinesin-like protein KIF12 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D2Z8 777 5.7e-81 Kinesin-like protein KIF12 OS=Mus musculus GN=Kif12 PE=2 SV=1 PF00225//PF02183//PF00170 Kinesin motor domain//Homeobox associated leucine zipper//bZIP transcription factor GO:0007018//GO:0007017//GO:0006355 microtubule-based movement//microtubule-based process//regulation of transcription, DNA-templated GO:0003777//GO:0005524//GO:0003700//GO:0008017//GO:0043565 microtubule motor activity//ATP binding//transcription factor activity, sequence-specific DNA binding//microtubule binding//sequence-specific DNA binding GO:0045298//GO:0005874//GO:0005667 tubulin complex//microtubule//transcription factor complex KOG4280 Kinesin-like protein Cluster-15397.0 BP_3 12.00 1.51 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-15397.1 BP_3 9.00 1.45 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15400.1 BP_3 2.00 2.97 310 815900527 XP_012236408.1 243 1.3e-18 PREDICTED: CBP80/20-dependent translation initiation factor isoform X2 [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00941 FAD binding domain in molybdopterin dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3942 MIF4G domain-containing protein Cluster-15402.0 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15411.0 BP_3 1.00 0.42 404 749789932 XP_011148248.1 344 3.4e-30 PREDICTED: uncharacterized protein LOC105188467 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06390//PF08515//PF05887//PF15754 Neuroendocrine-specific golgi protein P55 (NESP55)//Transforming growth factor beta type I GS-motif//Procyclic acidic repetitive protein (PARP)//Sperm equatorial segment protein 1 GO:0007340//GO:0007342//GO:0007178//GO:0071107//GO:0016310//GO:0006468//GO:0009069 acrosome reaction//fusion of sperm to egg plasma membrane//transmembrane receptor protein serine/threonine kinase signaling pathway//response to parathyroid hormone//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//ATP binding GO:0016020//GO:0001669 membrane//acrosomal vesicle -- -- Cluster-15412.0 BP_3 3.00 0.35 703 4503139 NP_001899.1 1288 2.0e-139 cathepsin B preproprotein [Homo sapiens]>gi|22538431|ref|NP_680090.1| cathepsin B preproprotein [Homo sapiens]>gi|22538433|ref|NP_680091.1| cathepsin B preproprotein [Homo sapiens]>gi|22538435|ref|NP_680092.1| cathepsin B preproprotein [Homo sapiens]>gi|22538437|ref|NP_680093.1| cathepsin B preproprotein [Homo sapiens]>gi|578815059|ref|XP_006716307.1| PREDICTED: cathepsin B isoform X1 [Homo sapiens]>gi|578815061|ref|XP_006716308.1| PREDICTED: cathepsin B isoform X1 [Homo sapiens]>gi|767950275|ref|XP_011542114.1| PREDICTED: cathepsin B isoform X1 [Homo sapiens]>gi|68067549|sp|P07858.3|CATB_HUMAN RecName: Full=Cathepsin B; AltName: Full=APP secretase; Short=APPS; AltName: Full=Cathepsin B1; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor>gi|291888|gb|AAC37547.1| cathepsin B [Homo sapiens]>gi|63102437|gb|AAH95408.1| Cathepsin B [Homo sapiens]>gi|119586034|gb|EAW65630.1| cathepsin B, isoform CRA_a [Homo sapiens]>gi|119586036|gb|EAW65632.1| cathepsin B, isoform CRA_a [Homo sapiens]>gi|119586037|gb|EAW65633.1| cathepsin B, isoform CRA_a [Homo sapiens]>gi|119586038|gb|EAW65634.1| cathepsin B, isoform CRA_a [Homo sapiens]>gi|119586039|gb|EAW65635.1| cathepsin B, isoform CRA_a [Homo sapiens]>gi|119586040|gb|EAW65636.1| cathepsin B, isoform CRA_a [Homo sapiens]>gi|168277954|dbj|BAG10955.1| cathepsin B precursor [synthetic construct]>gi|193786804|dbj|BAG52127.1| unnamed protein product [Homo sapiens] 158261500 AK290239.1 703 0 Homo sapiens cDNA FLJ78235 complete cds K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07858 1288 8.3e-141 Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 PF08127//PF00112 Peptidase family C1 propeptide//Papain family cysteine protease GO:0009611//GO:0006508//GO:0070670//GO:0014070//GO:0042981//GO:0007519//GO:0050790//GO:0097067//GO:0045087//GO:0043434//GO:0009749//GO:0014075//GO:0045471//GO:0009612//GO:0060548//GO:0006914 response to wounding//proteolysis//response to interleukin-4//response to organic cyclic compound//regulation of apoptotic process//skeletal muscle tissue development//regulation of catalytic activity//cellular response to thyroid hormone stimulus//innate immune response//response to peptide hormone//response to glucose//response to amine//response to ethanol//response to mechanical stimulus//negative regulation of cell death//autophagy GO:0004197//GO:0030984//GO:0008234//GO:0042277 cysteine-type endopeptidase activity//kininogen binding//cysteine-type peptidase activity//peptide binding GO:0005901//GO:0036021//GO:0042470//GO:0048471//GO:0042383//GO:0005730//GO:0005739//GO:0016324//GO:0005615//GO:0009897 caveola//endolysosome lumen//melanosome//perinuclear region of cytoplasm//sarcolemma//nucleolus//mitochondrion//apical plasma membrane//extracellular space//external side of plasma membrane KOG1543 Cysteine proteinase Cathepsin L Cluster-15413.0 BP_3 5.39 1.16 515 546683764 ERL93529.1 587 2.9e-58 hypothetical protein D910_10818 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BDJ4 142 4.7e-08 Lipase member H OS=Oryctolagus cuniculus GN=LIPH PE=2 SV=1 PF00087//PF01383 Snake toxin//CpcD/allophycocyanin linker domain GO:0009405 pathogenesis -- -- GO:0005576//GO:0030089 extracellular region//phycobilisome -- -- Cluster-15415.0 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15421.0 BP_3 5.00 0.33 1012 332376023 AEE63152.1 652 1.6e-65 unknown [Dendroctonus ponderosae] 675324092 CP009080.1 875 0 Verticillium dahliae JR2 chromosome 4, complete sequence K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 P0CX39 669 7.2e-69 40S ribosomal protein S8-A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPS8A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3283 40S ribosomal protein S8 Cluster-15421.1 BP_3 11.72 4.48 417 -- -- -- -- -- 697066922 XM_009650353.1 414 0 Verticillium dahliae VdLs.17 glucose-repressible protein mRNA -- -- -- -- P22151 235 6.2e-19 Glucose-repressible gene protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=grg-1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15425.0 BP_3 3.00 0.50 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15429.0 BP_3 5.00 1.33 472 283854615 ADB44903.1 250 3.1e-19 peritrophin [Macrobrachium nipponense] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-15430.0 BP_3 6.00 3.96 361 -- -- -- -- -- 697075623 XM_009653872.1 331 1.49786e-171 Verticillium dahliae VdLs.17 aerobactin siderophore biosynthesis protein iucB partial mRNA -- -- -- -- Q9UUE3 258 1.2e-21 Putative lysine N-acyltransferase C17G9.06c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC17G9.06c PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15432.0 BP_3 5.00 0.34 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15432.1 BP_3 9.00 0.33 1588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15436.0 BP_3 11.00 0.77 976 213493458 ACJ47904.1 671 9.9e-68 nascent polypeptide-associated complex alpha [Penaeus monodon] 808354748 NM_001306344.1 94 2.40484e-39 Caenorhabditis elegans ICD-2, isoform c (icd-2), partial mRNA K03626 EGD2, NACA nascent polypeptide-associated complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03626 Q94518 478 9.7e-47 Nascent polypeptide-associated complex subunit alpha OS=Drosophila melanogaster GN=Nacalpha PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2239 Transcription factor containing NAC and TS-N domains Cluster-15437.0 BP_3 2.00 2.97 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1544.0 BP_3 5.00 1.27 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15445.0 BP_3 2.00 0.38 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15447.0 BP_3 3.00 0.38 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15448.0 BP_3 5.54 0.38 999 478259330 ENN79232.1 650 2.8e-65 hypothetical protein YQE_04416, partial [Dendroctonus ponderosae]>gi|546675068|gb|ERL86323.1| hypothetical protein D910_03731 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15449.0 BP_3 9.00 0.46 1226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15450.0 BP_3 7.00 0.44 1062 646710809 KDR16227.1 1461 2.7e-159 Spectrin beta chain [Zootermopsis nevadensis] 170038032 XM_001846806.1 234 3.92154e-117 Culex quinquefasciatus spectrin beta chain, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 1352 4.8e-148 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF01297//PF07464//PF00435//PF07361//PF14942 Zinc-uptake complex component A periplasmic//Apolipophorin-III precursor (apoLp-III)//Spectrin repeat//Cytochrome b562//Organelle biogenesis, Muted-like protein GO:0006869//GO:0030001//GO:0022900//GO:0006118 lipid transport//metal ion transport//electron transport chain//obsolete electron transport GO:0005515//GO:0008289//GO:0020037//GO:0046872//GO:0005506//GO:0009055 protein binding//lipid binding//heme binding//metal ion binding//iron ion binding//electron carrier activity GO:0031083//GO:0030133//GO:0042597//GO:0005576 BLOC-1 complex//transport vesicle//periplasmic space//extracellular region KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-15452.0 BP_3 1.00 0.31 448 641651169 XP_008190032.1 293 3.1e-24 PREDICTED: fasciclin-2-like isoform X1 [Acyrthosiphon pisum] -- -- -- -- -- K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P22648 272 3.4e-23 Fasciclin-2 OS=Schistocerca americana GN=FAS2 PE=1 SV=2 PF13895//PF05790 Immunoglobulin domain//Immunoglobulin C2-set domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-15462.0 BP_3 2.00 0.49 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15471.0 BP_3 5.35 0.39 952 546670638 ERL83322.1 408 3.0e-37 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08236//PF00580 SRI (Set2 Rpb1 interacting) domain//UvrD/REP helicase N-terminal domain GO:0006355//GO:0006479//GO:0034968//GO:0006554 regulation of transcription, DNA-templated//protein methylation//histone lysine methylation//lysine catabolic process GO:0005524//GO:0018024 ATP binding//histone-lysine N-methyltransferase activity GO:0005694 chromosome -- -- Cluster-15474.0 BP_3 11.83 1.15 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15475.0 BP_3 10.00 1.53 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15484.0 BP_3 3.00 0.53 564 769838274 XP_011630294.1 141 1.6e-06 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15492.0 BP_3 2.00 0.39 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15498.0 BP_3 4.00 0.41 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15500.0 BP_3 3.00 0.31 754 765550846 KJE91467.1 219 2.0e-15 hsp97-like protein [Capsaspora owczarzaki ATCC 30864] 697069726 XM_009651752.1 645 0 Verticillium dahliae VdLs.17 heat shock protein Hsp88 partial mRNA K09485 HSP110 heat shock protein 110kDa http://www.genome.jp/dbget-bin/www_bget?ko:K09485 O74225 491 2.3e-48 Heat shock protein hsp88 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hsp88 PE=1 SV=1 PF09726//PF17121//PF00486 Transmembrane protein//Zinc finger, C3HC4 type (RING finger)//Transcriptional regulatory protein, C terminal GO:0006355//GO:0000160 regulation of transcription, DNA-templated//phosphorelay signal transduction system GO:0008270//GO:0003677//GO:0005515 zinc ion binding//DNA binding//protein binding GO:0016021 integral component of membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-15501.0 BP_3 1.00 0.49 389 443686989 ELT90106.1 243 1.7e-18 hypothetical protein CAPTEDRAFT_166259 [Capitella teleta] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q8BYF6 221 2.4e-17 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus GN=Slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-15517.1 BP_3 6.00 0.44 953 857976527 CEO97322.1 269 4.0e-21 hypothetical protein PBRA_000667 [Plasmodiophora brassicae] 697081965 XM_009656047.1 924 0 Verticillium dahliae VdLs.17 polysaccharide deacetylase family protein mRNA -- -- -- -- Q8DP63 279 1.1e-23 Peptidoglycan-N-acetylglucosamine deacetylase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=pgdA PE=1 SV=1 PF03065//PF01522 Glycosyl hydrolase family 57//Polysaccharide deacetylase GO:0005975//GO:0006807 carbohydrate metabolic process//nitrogen compound metabolic process GO:0003824//GO:0016810 catalytic activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-1552.0 BP_3 1.65 1.01 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15524.0 BP_3 5.00 1.23 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15525.0 BP_3 2.00 0.43 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15541.0 BP_3 10.00 1.56 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15546.0 BP_3 2.00 0.81 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15551.1 BP_3 1.00 0.31 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15552.1 BP_3 2.00 0.33 583 642911859 XP_008200777.1 298 1.1e-24 PREDICTED: uncharacterized protein LOC103315005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15558.1 BP_3 2.00 1.01 385 -- -- -- -- -- 768311756 CP010984.1 379 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15558.2 BP_3 5.00 0.52 759 844837402 XP_012792470.1 305 2.1e-25 60S ribosomal protein L37, partial [Schistosoma haematobium]>gi|685956515|gb|KGB32692.1| 60S ribosomal protein L37, partial [Schistosoma haematobium] 697073566 XM_009653147.1 562 0 Verticillium dahliae VdLs.17 60S ribosomal protein L37 mRNA K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q9C0T1 358 6.2e-33 60S ribosomal protein L37 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=rpl37 PE=3 SV=1 PF01155//PF01907 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Ribosomal protein L37e GO:0042254//GO:0006412//GO:0006464 ribosome biogenesis//translation//cellular protein modification process GO:0016151//GO:0003735 nickel cation binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3475 60S ribosomal protein L37 Cluster-1556.1 BP_3 3.00 0.40 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15560.0 BP_3 8.00 0.92 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15561.0 BP_3 4.00 0.37 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15567.0 BP_3 17.00 0.81 1301 72058324 XP_798304.1 861 1.2e-89 PREDICTED: 40S ribosomal protein S3 [Strongylocentrotus purpuratus] 768311759 CP010987.1 1164 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 O60128 876 9.2e-93 40S ribosomal protein S3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rps3 PE=1 SV=1 PF07650//PF04728 KH domain//Lipoprotein leucine-zipper -- -- GO:0003723 RNA binding GO:0019867 outer membrane KOG3181 40S ribosomal protein S3 Cluster-15572.0 BP_3 3.00 0.33 724 340539152 AEK49107.1 1039 1.6e-110 Tudor staphylococcal nuclease [Penaeus monodon] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q78PY7 768 1.7e-80 Staphylococcal nuclease domain-containing protein 1 OS=Mus musculus GN=Snd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2039 Transcriptional coactivator p100 Cluster-15577.0 BP_3 19.32 0.41 2570 861610178 KMQ85078.1 793 1.9e-81 dna-mediated transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16983//PF01136 Molybdate transporter of MFS superfamily//Peptidase family U32 GO:0006508//GO:0015689 proteolysis//molybdate ion transport GO:0008233//GO:0015098 peptidase activity//molybdate ion transmembrane transporter activity -- -- -- -- Cluster-15578.0 BP_3 21.00 5.46 477 300791208 ADK34020.1 478 1.2e-45 ribosomal protein S15 [Prionchulus punctatus] 661902829 NM_001297462.1 148 1.08673e-69 Poecilia reticulata ribosomal protein S15 (rps15), mRNA K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 P62845 460 5.8e-45 40S ribosomal protein S15 OS=Rattus norvegicus GN=Rps15 PE=1 SV=2 PF00203 Ribosomal protein S19 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0898 40S ribosomal protein S15 Cluster-1558.1 BP_3 2.00 0.44 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15581.0 BP_3 2.00 0.41 527 115443550 YP_778569.1 380 2.9e-34 50S ribosomal protein L16 [Bigelowiella natans]>gi|122233792|sp|Q06J58.1|RK16_BIGNA RecName: Full=50S ribosomal protein L16, chloroplastic (chloroplast) [Bigelowiella natans]>gi|110810195|gb|ABG91401.1| 50S ribosomal protein L16 [Bigelowiella natans] 761231856 KM881642.1 527 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C442 566 3.3e-57 50S ribosomal protein L16, chloroplastic OS=Oryza sativa subsp. indica GN=rpl16 PE=3 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005739//GO:0005840//GO:0009507 mitochondrion//ribosome//chloroplast KOG3422 Mitochondrial ribosomal protein L16 Cluster-15585.0 BP_3 7.00 0.63 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1559.0 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15593.1 BP_3 1.00 0.34 435 556765798 XP_005978155.1 425 1.5e-39 PREDICTED: probable phosphoketolase-like [Pantholops hodgsonii] 589106132 XM_006965027.1 233 5.51726e-117 Trichoderma reesei QM6a predicted protein (TRIREDRAFT_77481), mRNA -- -- -- -- Q8DJN6 526 1.2e-52 Probable phosphoketolase OS=Thermosynechococcus elongatus (strain BP-1) GN=tll1186 PE=3 SV=1 PF00485//PF09363 Phosphoribulokinase / Uridine kinase family//XFP C-terminal domain GO:0005975//GO:0008152 carbohydrate metabolic process//metabolic process GO:0016832//GO:0016301//GO:0005524 aldehyde-lyase activity//kinase activity//ATP binding -- -- -- -- Cluster-15594.0 BP_3 2.00 0.43 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15598.0 BP_3 3.00 0.67 506 -- -- -- -- -- 768311754 CP010982.1 500 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15599.0 BP_3 3.00 0.42 640 -- -- -- -- -- 525346445 KC793917.1 74 2.02977e-28 Scylla paramamosain clone Scpa25 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15604.1 BP_3 3.00 0.48 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02511 Thymidylate synthase complementing protein GO:0006206//GO:0006231 pyrimidine nucleobase metabolic process//dTMP biosynthetic process GO:0050660//GO:0050797 flavin adenine dinucleotide binding//thymidylate synthase (FAD) activity -- -- -- -- Cluster-15609.0 BP_3 2.00 0.46 501 642940307 XP_008201206.1 269 2.1e-21 PREDICTED: uncharacterized protein LOC103315118, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15613.0 BP_3 1.00 0.53 380 -- -- -- -- -- 596226139 XM_007224133.1 314 4.46863e-162 Prunus persica hypothetical protein (PRUPE_ppa017307mg) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15616.0 BP_3 5.32 0.38 968 -- -- -- -- -- 697075525 XM_009653839.1 828 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF06992//PF14672 Replication protein P//Late cornified envelope GO:0006270//GO:0008544 DNA replication initiation//epidermis development -- -- -- -- -- -- Cluster-15616.1 BP_3 5.00 0.57 711 -- -- -- -- -- 697075525 XM_009653839.1 555 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15616.2 BP_3 4.00 1.49 420 -- -- -- -- -- 768311758 CP010986.1 420 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15616.3 BP_3 3.68 1.00 469 -- -- -- -- -- 768311754 CP010982.1 453 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1562.0 BP_3 9.76 0.37 1562 270015294 EFA11742.1 323 3.6e-27 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15626.0 BP_3 1.00 0.53 380 -- -- -- -- -- 697076597 XM_009654192.1 369 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15627.1 BP_3 11.00 0.32 1964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00769//PF02913//PF08085//PF00015 Ezrin/radixin/moesin family//FAD linked oxidases, C-terminal domain//Entericidin EcnA/B family//Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0009636//GO:0007165 response to toxic substance//signal transduction GO:0004871//GO:0050660//GO:0008092//GO:0003824 signal transducer activity//flavin adenine dinucleotide binding//cytoskeletal protein binding//catalytic activity GO:0016020//GO:0005737//GO:0019898 membrane//cytoplasm//extrinsic component of membrane -- -- Cluster-15628.0 BP_3 4.00 0.48 692 -- -- -- -- -- 392303590 JX102623.1 670 0 Scylla paramamosain microsatellite Spm52 sequence -- -- -- -- -- -- -- -- PF04962 KduI/IolB family -- -- GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses -- -- -- -- Cluster-15631.0 BP_3 6.00 0.32 1199 646700578 KDR10688.1 532 1.6e-51 Insulin-like peptide receptor [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15632.0 BP_3 4.00 0.46 707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-15641.0 BP_3 2.00 1.06 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15656.0 BP_3 7.00 0.72 759 642925028 XP_008194142.1 227 2.3e-16 PREDICTED: DNA ligase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15657.0 BP_3 4.00 0.37 813 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05273 Poxvirus RNA polymerase 22 kDa subunit GO:0006351//GO:0019083//GO:0006206//GO:0006144 transcription, DNA-templated//viral transcription//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-1566.0 BP_3 7.00 0.48 988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15663.0 BP_3 4.00 0.35 840 646717173 KDR20134.1 645 8.8e-65 Viral IAP-associated factor-like protein [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9H2J4 553 1.7e-55 Phosducin-like protein 3 OS=Homo sapiens GN=PDCL3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3170 Conserved phosducin-like protein Cluster-15671.1 BP_3 2.00 0.33 587 767935850 XP_011541681.1 434 1.8e-40 PREDICTED: interferon regulatory factor 1 isoform X2 [Homo sapiens] 767935851 XR_427711.2 587 0 PREDICTED: Homo sapiens interferon regulatory factor 1 (IRF1), transcript variant X3, misc_RNA K09444 IRF1 interferon regulatory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09444 P10914 434 7.4e-42 Interferon regulatory factor 1 OS=Homo sapiens GN=IRF1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-15679.0 BP_3 3.00 0.41 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15689.0 BP_3 1.00 0.32 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15695.0 BP_3 2.00 0.38 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15702.0 BP_3 10.00 0.36 1630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15704.0 BP_3 12.00 0.45 1566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15717.0 BP_3 3.00 0.38 676 675382484 KFM75381.1 217 3.0e-15 hypothetical protein X975_12632, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04769 Mating-type protein MAT alpha 1 HMG-box GO:0045895//GO:0007531 positive regulation of mating-type specific transcription, DNA-templated//mating type determination GO:0008301 DNA binding, bending GO:0005634 nucleus -- -- Cluster-15718.0 BP_3 4.00 0.31 904 260797919 XP_002593948.1 638 6.1e-64 hypothetical protein BRAFLDRAFT_98245 [Branchiostoma floridae]>gi|229279180|gb|EEN49959.1| hypothetical protein BRAFLDRAFT_98245 [Branchiostoma floridae] -- -- -- -- -- K10707 VAPB, ALS8 vesicle-associated membrane protein-associated protein B http://www.genome.jp/dbget-bin/www_bget?ko:K10707 A2VDZ9 578 2.3e-58 Vesicle-associated membrane protein-associated protein B OS=Bos taurus GN=VAPB PE=2 SV=1 PF08172//PF06005 CASP C terminal//Protein of unknown function (DUF904) GO:0006891//GO:0000917//GO:0043093 intra-Golgi vesicle-mediated transport//barrier septum assembly//FtsZ-dependent cytokinesis -- -- GO:0030173//GO:0005737 integral component of Golgi membrane//cytoplasm KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-1572.0 BP_3 5.00 0.35 988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15721.0 BP_3 62.82 2.40 1551 392315969 AFM57703.1 760 7.5e-78 glutathione S-transferase D2 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VG95 423 3.7e-40 Glutathione S-transferase D5 OS=Drosophila melanogaster GN=GstD5 PE=3 SV=2 PF13409//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-15721.1 BP_3 10.67 0.37 1667 392315969 AFM57703.1 696 2.1e-70 glutathione S-transferase D2 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VG95 423 4.0e-40 Glutathione S-transferase D5 OS=Drosophila melanogaster GN=GstD5 PE=3 SV=2 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-15728.0 BP_3 15.00 1.03 992 861563745 KMQ81409.1 281 1.7e-22 non-classical export protein, partial [Lasius niger] 768311753 CP010981.1 974 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- Q12207 147 2.4e-08 Non-classical export protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NCE102 PE=1 SV=1 PF01284//PF00345 Membrane-associating domain//Pili and flagellar-assembly chaperone, PapD N-terminal domain GO:0071555 cell wall organization -- -- GO:0030288//GO:0016020 outer membrane-bounded periplasmic space//membrane -- -- Cluster-15729.1 BP_3 23.00 0.88 1549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15734.0 BP_3 2.00 0.64 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-15735.0 BP_3 2.00 0.35 569 556765772 XP_005978142.1 159 1.3e-08 PREDICTED: putative sterigmatocystin biosynthesis monooxygenase stcW-like [Pantholops hodgsonii] 697076078 XM_009654027.1 465 0 Verticillium dahliae VdLs.17 cyclopentanone 1,2-monooxygenase partial mRNA -- -- -- -- Q8GAW0 360 2.7e-33 Cyclopentanone 1,2-monooxygenase OS=Comamonas sp. (strain NCIMB 9872) GN=cpnB PE=1 SV=3 PF00743 Flavin-binding monooxygenase-like GO:0055114 oxidation-reduction process GO:0050661//GO:0004499//GO:0050660 NADP binding//N,N-dimethylaniline monooxygenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-15743.0 BP_3 8.59 0.77 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15747.0 BP_3 4.00 0.40 776 -- -- -- -- -- 768311752 CP010980.1 676 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- PF08114//PF06305//PF10389//PF03376 ATPase proteolipid family//Protein of unknown function (DUF1049)//Bacteriophage coat protein B//Adenovirus E3B protein GO:0050790 regulation of catalytic activity GO:0030234 enzyme regulator activity GO:0016020//GO:0005887//GO:0019028 membrane//integral component of plasma membrane//viral capsid -- -- Cluster-15749.0 BP_3 9.00 0.52 1121 290989589 XP_002677420.1 226 4.5e-16 predicted protein [Naegleria gruberi]>gi|284091027|gb|EFC44676.1| predicted protein [Naegleria gruberi] 697082691 XM_009656301.1 980 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF02993 Minor capsid protein VI -- -- -- -- GO:0019028 viral capsid -- -- Cluster-15755.0 BP_3 14.00 0.61 1407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15759.0 BP_3 1.00 15.53 232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15761.0 BP_3 4.00 0.79 536 343183155 BAK61430.1 573 1.3e-56 myosin heavy chain type b [Marsupenaeus japonicus] 410509305 AB758441.1 125 7.4978e-57 Penaeus monodon MYH1 mRNA for myosin heavy chain type 1, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 441 1.0e-42 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF03242//PF02736//PF00063 Late embryogenesis abundant protein//Myosin N-terminal SH3-like domain//Myosin head (motor domain) GO:0006950 response to stress GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-15766.0 BP_3 2.00 0.32 590 -- -- -- -- -- 697091373 XM_009660156.1 584 0 Verticillium dahliae VdLs.17 protein kinase gsk3 mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG0658 Glycogen synthase kinase-3 Cluster-15778.0 BP_3 1.00 0.35 430 646715519 KDR19096.1 348 1.2e-30 FYVE, RhoGEF and PH domain-containing protein 6 [Zootermopsis nevadensis] -- -- -- -- -- K05724 FGD5_6 FYVE, RhoGEF and PH domain containing 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K05724 Q6ZV73 261 6.2e-22 FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens GN=FGD6 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1729 FYVE finger containing protein Cluster-15780.0 BP_3 1.00 0.53 380 815789458 XP_012215272.1 165 1.8e-09 PREDICTED: protein lethal(2)essential for life-like [Linepithema humile] -- -- -- -- -- -- -- -- -- P02517 144 2.0e-08 Heat shock protein 26 OS=Drosophila melanogaster GN=Hsp26 PE=1 SV=2 PF03587 EMG1/NEP1 methyltransferase -- -- GO:0008168 methyltransferase activity -- -- KOG3591 Alpha crystallins Cluster-15782.0 BP_3 2.00 1.17 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15793.0 BP_3 2.00 0.41 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15797.0 BP_3 1.00 0.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15803.1 BP_3 6.00 0.51 862 338224452 AEI88104.1 715 6.9e-73 midline fasciclin [Scylla paramamosain] 338224451 HM217872.1 401 0 Scylla paramamosain isolate 2 midline fasciclin mRNA, partial cds -- -- -- -- P15278 278 1.3e-23 Fasciclin-3 OS=Drosophila melanogaster GN=Fas3 PE=2 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-15807.0 BP_3 3.00 0.52 571 593756145 XP_007116915.1 181 3.8e-11 PREDICTED: enoyl-CoA delta isomerase 2, mitochondrial [Physeter catodon] -- -- -- -- -- K13239 PECI peroxisomal 3,2-trans-enoyl-CoA isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K13239 Q9WUR2 148 1.1e-08 Enoyl-CoA delta isomerase 2, mitochondrial OS=Mus musculus GN=Eci2 PE=1 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- -- -- Cluster-1582.0 BP_3 5.00 1.45 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15833.0 BP_3 41.00 2.23 1176 642929158 XP_008195717.1 587 6.5e-58 PREDICTED: uncharacterized protein LOC103313654 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1584.0 BP_3 1.00 0.86 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15852.0 BP_3 2.00 1.37 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15854.1 BP_3 3.00 0.53 563 684393772 XP_009170696.1 650 1.5e-65 hypothetical protein T265_07011 [Opisthorchis viverrini]>gi|663049509|gb|KER25552.1| hypothetical protein T265_07011 [Opisthorchis viverrini] 768311753 CP010981.1 557 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 Q5B0C0 745 6.1e-78 Heat shock 70 kDa protein OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=AN6010 PE=1 SV=1 PF02782 FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-15858.0 BP_3 3.00 0.76 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02535//PF06459//PF02724//PF05793//PF02932//PF11744//PF04147//PF00183//PF01080 ZIP Zinc transporter//Ryanodine Receptor TM 4-6//CDC45-like protein//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Neurotransmitter-gated ion-channel transmembrane region//Aluminium activated malate transporter//Nop14-like family//Hsp90 protein//Presenilin GO:0006874//GO:0006270//GO:0055085//GO:0006816//GO:0006811//GO:0006367//GO:0015743//GO:0032968//GO:0006457//GO:0006950//GO:0030001 cellular calcium ion homeostasis//DNA replication initiation//transmembrane transport//calcium ion transport//ion transport//transcription initiation from RNA polymerase II promoter//malate transport//positive regulation of transcription elongation from RNA polymerase II promoter//protein folding//response to stress//metal ion transport GO:0051082//GO:0005524//GO:0046873//GO:0005219//GO:0003677//GO:0004190 unfolded protein binding//ATP binding//metal ion transmembrane transporter activity//ryanodine-sensitive calcium-release channel activity//DNA binding//aspartic-type endopeptidase activity GO:0032040//GO:0005622//GO:0016021//GO:0016020//GO:0005634 small-subunit processome//intracellular//integral component of membrane//membrane//nucleus -- -- Cluster-15862.0 BP_3 6.00 0.79 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-15864.0 BP_3 10.00 0.43 1422 754348974 XP_004347002.2 850 2.5e-88 mDj3 [Capsaspora owczarzaki ATCC 30864]>gi|765554099|gb|KJE94720.1| mDj3 [Capsaspora owczarzaki ATCC 30864] 697067698 XM_009650739.1 1251 0 Verticillium dahliae VdLs.17 chaperone protein dnaJ 2 partial mRNA K09503 DNAJA2 DnaJ homolog subfamily A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09503 O74752 1007 6.5e-108 Mitochondrial protein import protein mas5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mas5 PE=3 SV=1 PF01155//PF11023//PF00684 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-ribbon containing domain//DnaJ central domain GO:0006464 cellular protein modification process GO:0016151//GO:0051082//GO:0031072 nickel cation binding//unfolded protein binding//heat shock protein binding GO:0005887 integral component of plasma membrane KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-15875.0 BP_3 72.00 1.94 2080 270015779 EFA12227.1 470 4.3e-44 hypothetical protein TcasGA2_TC000016 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02798 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-15882.0 BP_3 15.95 1.54 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15886.0 BP_3 4.00 0.33 884 524872934 XP_005093222.1 375 1.9e-33 PREDICTED: adenine phosphoribosyltransferase-like [Aplysia californica] -- -- -- -- -- K00759 APRT, apt adenine phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00759 Q183I0 308 4.6e-27 Adenine phosphoribosyltransferase OS=Peptoclostridium difficile (strain 630) GN=apt PE=3 SV=1 PF00156 Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process -- -- -- -- KOG1712 Adenine phosphoribosyl transferases Cluster-15892.0 BP_3 2.00 0.31 604 -- -- -- -- -- 697084896 XM_009657075.1 547 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- A4QTA3 317 2.8e-28 Eukaryotic translation initiation factor 3 subunit J OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) GN=HCR1 PE=3 SV=1 PF08597//PF09507 Translation initiation factor eIF3 subunit//DNA polymerase subunit Cdc27 GO:0006446//GO:0006260 regulation of translational initiation//DNA replication GO:0003743 translation initiation factor activity GO:0005737//GO:0005852//GO:0005634//GO:0005840 cytoplasm//eukaryotic translation initiation factor 3 complex//nucleus//ribosome -- -- Cluster-15896.0 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-159.0 BP_3 147.11 4.73 1791 642939143 XP_008197185.1 1314 5.0e-142 PREDICTED: acyl-CoA Delta(11) desaturase-like [Tribolium castaneum]>gi|642939145|ref|XP_008197190.1| PREDICTED: acyl-CoA Delta(11) desaturase-like [Tribolium castaneum]>gi|270016353|gb|EFA12799.1| hypothetical protein TcasGA2_TC014821 [Tribolium castaneum]>gi|576636746|gb|AHH30815.1| fatty acid desaturase D8 [Tribolium castaneum] 817201577 XM_012421119.1 47 6.00592e-13 PREDICTED: Orussus abietinus acyl-CoA Delta(11) desaturase-like (LOC105697631), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 Q6US81 970 1.6e-103 Acyl-CoA Delta(11) desaturase OS=Spodoptera littoralis PE=1 SV=1 PF00487//PF10380 Fatty acid desaturase//Transcription factor CRF1 GO:0006629//GO:0060962 lipid metabolic process//regulation of ribosomal protein gene transcription from RNA polymerase II promoter GO:0003712//GO:0016491 transcription cofactor activity//oxidoreductase activity GO:0005667 transcription factor complex KOG1600 Fatty acid desaturase Cluster-15900.0 BP_3 19.34 0.67 1693 642934722 XP_008197785.1 785 1.0e-80 PREDICTED: uncharacterized protein LOC658747 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03340 Poxvirus rifampicin resistance protein GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-15904.0 BP_3 2.00 0.37 554 607357601 EZA52050.1 351 7.1e-31 hypothetical protein X777_09071 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04508//PF13404//PF04218//PF01498 Viral A-type inclusion protein repeat//AsnC-type helix-turn-helix domain//CENP-B N-terminal DNA-binding domain//Transposase GO:0016032//GO:0006355//GO:0015074//GO:0006313 viral process//regulation of transcription, DNA-templated//DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- -- -- Cluster-15907.0 BP_3 1.00 0.35 427 -- -- -- -- -- 392996986 AC243971.2 427 0 Homo sapiens BAC clone CH17-437O13 from chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1591.0 BP_3 4.74 0.63 654 642911891 XP_008199011.1 389 3.3e-35 PREDICTED: short stature homeobox protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10503 Esterase PHB depolymerase -- -- -- -- GO:0005576 extracellular region -- -- Cluster-15916.0 BP_3 2.00 0.53 475 242017839 XP_002429393.1 497 7.2e-48 hypothetical protein Phum_PHUM431970 [Pediculus humanus corporis]>gi|212514312|gb|EEB16655.1| hypothetical protein Phum_PHUM431970 [Pediculus humanus corporis] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 414 1.3e-39 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-15919.0 BP_3 7.00 0.31 1381 -- -- -- -- -- 767948686 XM_011516557.1 1381 0 PREDICTED: Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15923.0 BP_3 3.00 0.31 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15928.0 BP_3 11.00 0.95 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15929.0 BP_3 2.00 0.35 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1593.0 BP_3 70.00 3.50 1257 642913424 XP_008201005.1 448 9.2e-42 PREDICTED: calcium-binding mitochondrial carrier protein Aralar1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15932.0 BP_3 14.00 1.08 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15938.0 BP_3 4.00 0.48 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15939.1 BP_3 4.00 0.53 657 325303722 DAA34557.1 287 2.2e-23 TPA_exp: translation initiation factor 5A eIF-5A [Amblyomma variegatum] 697069700 XM_009651739.1 654 0 Verticillium dahliae VdLs.17 eukaryotic translation initiation factor 5A-2 mRNA K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 O94083 324 4.7e-29 Eukaryotic translation initiation factor 5A OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ANB1 PE=3 SV=1 PF01287//PF00664 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//ABC transporter transmembrane region GO:0006452//GO:0055085//GO:0006810//GO:0006448//GO:0045905//GO:0045901 translational frameshifting//transmembrane transport//transport//regulation of translational elongation//positive regulation of translational termination//positive regulation of translational elongation GO:0043022//GO:0003723//GO:0005524//GO:0003746//GO:0042626 ribosome binding//RNA binding//ATP binding//translation elongation factor activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0005840 integral component of membrane//ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-15948.0 BP_3 1.00 0.46 394 262400975 ACY66390.1 557 6.6e-55 FK506-binding protein 1A [Scylla paramamosain]>gi|345452845|gb|AEN94574.1| FK506-binding protein 1A [Scylla paramamosain] 345452844 HQ260920.1 361 0 Scylla paramamosain FK506-binding protein 1A mRNA, complete cds K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 P48375 460 4.8e-45 12 kDa FK506-binding protein OS=Drosophila melanogaster GN=FK506-bp2 PE=3 SV=2 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase GO:0006457 protein folding -- -- -- -- KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-15952.0 BP_3 3.00 0.51 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15954.0 BP_3 2.00 0.32 591 662199173 XP_008472741.1 143 1.0e-06 PREDICTED: nephrin [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15955.0 BP_3 3.00 0.51 575 675365925 KFM58827.1 231 6.1e-17 Zinc finger MYM-type protein 6, partial [Stegodyphus mimosarum] 462298027 APGK01051817.1 108 2.27864e-47 Dendroctonus ponderosae Seq01051827, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15957.0 BP_3 9.55 0.85 831 332374478 AEE62380.1 634 1.6e-63 unknown [Dendroctonus ponderosae]>gi|546684527|gb|ERL94158.1| hypothetical protein D910_11440 [Dendroctonus ponderosae] -- -- -- -- -- K07922 RAB36 Ras-related protein Rab-36 http://www.genome.jp/dbget-bin/www_bget?ko:K07922 O95755 539 7.0e-54 Ras-related protein Rab-36 OS=Homo sapiens GN=RAB36 PE=2 SV=2 PF13691//PF08477//PF01926//PF02421//PF00025//PF03193//PF04670//PF00910//PF10662//PF00071 tRNase Z endonuclease//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ferrous iron transport protein B//ADP-ribosylation factor family//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//RNA helicase//Ethanolamine utilisation - propanediol utilisation//Ras family GO:0006576//GO:0008033//GO:0015684//GO:0007264 cellular biogenic amine metabolic process//tRNA processing//ferrous iron transport//small GTPase mediated signal transduction GO:0015093//GO:0003723//GO:0005524//GO:0003924//GO:0005525//GO:0003724 ferrous iron transmembrane transporter activity//RNA binding//ATP binding//GTPase activity//GTP binding//RNA helicase activity GO:0016021 integral component of membrane -- -- Cluster-15961.0 BP_3 2.00 0.42 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15971.0 BP_3 3.00 0.79 475 426390256 XP_004061522.1 598 1.4e-59 PREDICTED: 60S ribosomal protein L28 isoform 1 [Gorilla gorilla gorilla] 209915582 NM_000991.4 472 0 Homo sapiens ribosomal protein L28 (RPL28), transcript variant 2, mRNA K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 P46779 599 4.4e-61 60S ribosomal protein L28 OS=Homo sapiens GN=RPL28 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-15977.0 BP_3 9.00 0.62 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05236 Transcription initiation factor TFIID component TAF4 family GO:0006352 DNA-templated transcription, initiation -- -- GO:0005669 transcription factor TFIID complex -- -- Cluster-15978.0 BP_3 7.00 0.37 1194 664818432 AIF73508.1 1505 2.4e-164 UV2 opsin, partial [Neogonodactylus oerstedii] 817192887 XM_012416467.1 35 1.85738e-06 PREDICTED: Orussus abietinus opsin, blue-sensitive (LOC105695145), mRNA K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 O61303 1095 3.4e-118 Opsin, ultraviolet-sensitive OS=Apis mellifera GN=UVOP PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-15978.1 BP_3 1.00 6.33 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15987.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16.0 BP_3 10.00 7.60 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1600.0 BP_3 5.90 1.52 479 642915881 XP_008196364.1 141 1.4e-06 PREDICTED: cuticle protein 65-like [Tribolium castaneum]>gi|270004064|gb|EFA00512.1| hypothetical protein TcasGA2_TC003376 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16001.1 BP_3 15.27 0.58 1552 821475571 XP_012401294.1 640 6.2e-64 PREDICTED: zinc finger protein 260-like [Sarcophilus harrisii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96NI8 602 6.5e-61 Zinc finger protein 570 OS=Homo sapiens GN=ZNF570 PE=2 SV=1 PF13912//PF02892//PF02325//PF07776//PF00096//PF13465 C2H2-type zinc finger//BED zinc finger//YGGT family//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-16005.0 BP_3 16.00 0.59 1592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1601.0 BP_3 19.00 0.66 1677 270003365 EEZ99812.1 276 1.1e-21 hypothetical protein TcasGA2_TC002592 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NBX4 194 1.4e-13 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-16011.0 BP_3 1.00 0.46 394 82795531 ABB91679.1 323 8.9e-28 calcified cuticle protein CP15.0 [Callinectes sapidus] 82795530 DQ288154.1 294 6.09946e-151 Callinectes sapidus calcified cuticle protein CP15.0 mRNA, complete cds -- -- -- -- P81583 223 1.4e-17 Cuticle protein CP1499 OS=Cancer pagurus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16018.0 BP_3 17.00 0.84 1269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16020.0 BP_3 7.59 0.37 1286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07086 Jagunal, ER re-organisation during oogenesis GO:0007029 endoplasmic reticulum organization -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-16021.0 BP_3 1.00 12.70 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16033.0 BP_3 6.00 0.87 626 831770872 XP_012753131.1 146 4.8e-07 hypothetical protein SAMD00019534_072700 [Acytostelium subglobosum LB1]>gi|735853763|dbj|GAM24095.1| hypothetical protein SAMD00019534_072700 [Acytostelium subglobosum LB1] 768311756 CP010984.1 380 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- O74735 152 4.0e-09 Metal homeostasis factor atx1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=atx1 PE=3 SV=1 PF02932//PF00403 Neurotransmitter-gated ion-channel transmembrane region//Heavy-metal-associated domain GO:0030001//GO:0006811 metal ion transport//ion transport GO:0046872 metal ion binding GO:0016020 membrane KOG1603 Copper chaperone Cluster-16034.0 BP_3 1.00 0.39 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16036.0 BP_3 9.00 1.28 631 290783836 ADD62496.1 173 3.5e-10 gastrolith protein 10 [Cherax quadricarinatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16940 Chloroplast envelope transporter -- -- -- -- GO:0009507 chloroplast -- -- Cluster-16049.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1605.0 BP_3 7.00 0.88 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16057.1 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1606.0 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16066.0 BP_3 3.00 0.38 677 -- -- -- -- -- 768311759 CP010987.1 674 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- PF10466 Saccharopepsin inhibitor I34 GO:0010951 negative regulation of endopeptidase activity GO:0004866 endopeptidase inhibitor activity -- -- -- -- Cluster-1607.0 BP_3 11.77 1.23 753 332375737 AEE63009.1 811 4.4e-84 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5PQ44 441 1.5e-42 Uncharacterized protein C4orf22 homolog OS=Xenopus laevis PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16070.0 BP_3 1.00 0.82 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16082.0 BP_3 21.00 0.49 2363 642923667 XP_008193834.1 1761 9.7e-194 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1144 1.4e-123 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF01926//PF13304//PF00005 ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//ATP binding GO:0016021 integral component of membrane -- -- Cluster-16084.1 BP_3 6.00 3.96 361 -- -- -- -- -- 768311757 CP010985.1 202 7.69442e-100 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16085.0 BP_3 8.00 0.57 967 457867021 CCQ18621.1 447 9.2e-42 Translation initiation factor 1A [Sycon ciliatum] 612016962 XM_007493441.1 114 1.81542e-50 PREDICTED: Monodelphis domestica eukaryotic translation initiation factor 1A, X-chromosomal-like (LOC100013498), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 Q6GVM3 421 3.9e-40 Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Pan troglodytes GN=EIF1AY PE=2 SV=3 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-16086.0 BP_3 2.00 0.31 599 768033352 XP_011542255.1 764 1.0e-78 PREDICTED: ubiquitin-like modifier-activating enzyme 1 isoform X2 [Homo sapiens] 768033360 XM_011543956.1 599 0 PREDICTED: Homo sapiens ubiquitin-like modifier activating enzyme 1 (UBA1), transcript variant X6, mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 P22314 764 4.1e-80 Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens GN=UBA1 PE=1 SV=3 PF02170//PF03910 PAZ domain//Adenovirus minor core protein PV -- -- GO:0005515 protein binding GO:0019012 virion KOG2012 Ubiquitin activating enzyme UBA1 Cluster-16089.0 BP_3 3.00 0.85 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1609.0 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16092.0 BP_3 11.00 0.93 863 641650582 XP_008189789.1 534 6.7e-52 PREDICTED: uncharacterized protein LOC103311826 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225 DDE superfamily endonuclease//helix-turn-helix, Psq domain -- -- GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-16098.0 BP_3 11.00 1.95 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16108.0 BP_3 36.39 2.25 1071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-16111.0 BP_3 17.36 0.35 2685 642912712 XP_008200971.1 2210 9.5e-246 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642912714|ref|XP_008200972.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q9JKQ2 966 7.0e-103 Prestin OS=Meriones unguiculatus GN=SLC26A5 PE=1 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-16113.0 BP_3 1.00 1.05 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16115.0 BP_3 9.00 1.30 626 282721012 NP_001164206.1 287 2.1e-23 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) [Tribolium castaneum]>gi|642927503|ref|XP_008195295.1| PREDICTED: NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) isoform X1 [Tribolium castaneum]>gi|270011055|gb|EFA07503.1| hypothetical protein TcasGA2_TC009578 [Tribolium castaneum] -- -- -- -- -- K03938 NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16118.0 BP_3 5.00 0.67 651 -- -- -- -- -- 697077605 XM_009654537.1 648 0 Verticillium dahliae VdLs.17 NADH-ubiquinone oxidoreductase 21 kDa subunit mRNA -- -- -- -- Q02854 537 9.3e-54 NADH-ubiquinone oxidoreductase 20.9 kDa subunit OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=nuo20.9 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-1612.0 BP_3 2.00 0.99 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16120.0 BP_3 3.00 0.31 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16121.0 BP_3 16.83 0.46 2047 488520773 XP_004452314.1 486 5.9e-46 PREDICTED: oocyte zinc finger protein XlCOF6-like isoform X1 [Dasypus novemcinctus]>gi|821104969|ref|XP_012378288.1| PREDICTED: oocyte zinc finger protein XlCOF6-like isoform X1 [Dasypus novemcinctus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5JVG2 466 5.0e-45 Zinc finger protein 484 OS=Homo sapiens GN=ZNF484 PE=1 SV=1 PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-16123.0 BP_3 8.05 0.77 798 -- -- -- -- -- 768311752 CP010980.1 775 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16130.0 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16132.0 BP_3 4.00 0.34 867 780084737 XP_011673265.1 493 3.8e-47 PREDICTED: aquaporin-3-like [Strongylocentrotus purpuratus] 697083687 XM_009656644.1 757 0 Verticillium dahliae VdLs.17 aquaporin-3 partial mRNA K09876 AQP3 aquaporin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K09876 P23900 470 7.3e-46 Glycerol uptake/efflux facilitator protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FPS1 PE=1 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0224 Aquaporin (major intrinsic protein family) Cluster-16138.0 BP_3 4.00 0.38 803 762092794 XP_011428834.1 624 2.3e-62 PREDICTED: saccharopine dehydrogenase-like oxidoreductase [Crassostrea gigas] -- -- -- -- -- -- -- -- -- Q8NBX0 455 3.7e-44 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2733 Uncharacterized membrane protein Cluster-16140.0 BP_3 4.00 0.39 780 675386579 KFM79476.1 311 4.4e-26 Cyclin-dependent kinase 5 activator 1, partial [Stegodyphus mimosarum] 642932090 XM_970041.3 88 4.12245e-36 PREDICTED: Tribolium castaneum cyclin-dependent kinase 5 activator 1 (LOC664019), mRNA -- -- -- -- -- -- -- -- PF00264//PF03261 Common central domain of tyrosinase//Cyclin-dependent kinase 5 activator protein GO:0008152//GO:0045859 metabolic process//regulation of protein kinase activity GO:0016534//GO:0016491 cyclin-dependent protein kinase 5 activator activity//oxidoreductase activity GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex -- -- Cluster-16143.0 BP_3 2.00 0.58 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16146.0 BP_3 46.00 1.88 1470 108773740 ABG11961.1 1756 2.3e-193 tail muscle elongation factor 1 gamma [Procambarus clarkii] 262401138 FJ774751.1 447 0 Scylla paramamosain elongation factor 1 gamma mRNA, partial cds K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 Q9NJH0 1262 1.8e-137 Elongation factor 1-gamma OS=Drosophila melanogaster GN=Ef1gamma PE=2 SV=2 PF13409//PF01239//PF00647//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Protein prenyltransferase alpha subunit repeat//Elongation factor 1 gamma, conserved domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006448//GO:0006414//GO:0018342 regulation of translational elongation//translational elongation//protein prenylation GO:0005515//GO:0008318//GO:0003746 protein binding//protein prenyltransferase activity//translation elongation factor activity GO:0005840 ribosome KOG0867 Glutathione S-transferase Cluster-16150.0 BP_3 1.00 0.36 425 -- -- -- -- -- 768311758 CP010986.1 213 7.05866e-106 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1616.0 BP_3 11.01 0.73 1022 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16160.0 BP_3 10.34 2.15 524 642939900 XP_008200249.1 430 4.7e-40 PREDICTED: proton-coupled amino acid transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07034 Origin recognition complex (ORC) subunit 3 N-terminus GO:0006260 DNA replication GO:0003677 DNA binding GO:0005664 nuclear origin of replication recognition complex -- -- Cluster-16164.0 BP_3 10.00 0.49 1279 546685500 ERL94998.1 360 1.5e-31 hypothetical protein D910_12270 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16164.1 BP_3 3.00 0.31 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16168.0 BP_3 1.00 0.51 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16170.0 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16179.0 BP_3 8.00 2.51 445 -- -- -- -- -- 667650272 XM_008598746.1 105 8.07611e-46 Beauveria bassiana ARSEF 2860 glucose-repressible protein partial mRNA -- -- -- -- P22151 209 6.9e-16 Glucose-repressible gene protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=grg-1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16181.2 BP_3 3.00 0.71 496 755984839 XP_011310656.1 472 6.0e-45 PREDICTED: WW domain-binding protein 2 [Fopius arisanus]>gi|755984844|ref|XP_011310657.1| PREDICTED: WW domain-binding protein 2 [Fopius arisanus] -- -- -- -- -- -- -- -- -- Q969T9 329 9.4e-30 WW domain-binding protein 2 OS=Homo sapiens GN=WBP2 PE=1 SV=1 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0032266//GO:0043130 phosphatidylinositol-3-phosphate binding//ubiquitin binding -- -- KOG3294 WW domain binding protein WBP-2, contains GRAM domain Cluster-16185.0 BP_3 1.00 4.87 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16189.0 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16191.0 BP_3 1.00 0.35 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16193.0 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-16197.1 BP_3 13.00 0.41 1803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16201.0 BP_3 10.85 0.57 1206 642916232 XP_008190940.1 219 3.2e-15 PREDICTED: two pore potassium channel protein sup-9 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16203.0 BP_3 8.00 0.46 1137 -- -- -- -- -- 768311757 CP010985.1 1134 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16204.0 BP_3 1.00 0.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16211.0 BP_3 1.00 0.67 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16213.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16218.1 BP_3 24.00 0.56 2369 270016036 EFA12484.1 1172 1.9e-125 hypothetical protein TcasGA2_TC001508 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P16425 493 4.3e-48 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16219.0 BP_3 35.00 0.51 3581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16222.0 BP_3 61.00 6.69 731 253683402 NP_001153391.1 623 2.7e-62 ribosomal protein L6 [Nasonia vitripennis] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q6QMZ4 521 7.5e-52 60S ribosomal protein L6 OS=Chinchilla lanigera GN=RPL6 PE=2 SV=3 PF01159 Ribosomal protein L6e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1694 60s ribosomal protein L6 Cluster-16223.0 BP_3 1.00 0.32 443 405974301 EKC38957.1 254 1.0e-19 hypothetical protein CGI_10026724 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05280 Flagellar transcriptional activator (FlhC) GO:1902208//GO:0045893 regulation of bacterial-type flagellum assembly//positive regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-16225.0 BP_3 1.00 0.35 429 564287255 AHB84653.1 151 8.6e-08 leucine-rich repeat protein [Scylla serrata] 381145578 JQ681527.1 416 0 Scylla paramamosain leucine-rich repeat proteins (LRR) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16227.0 BP_3 7.45 0.36 1294 270005459 EFA01907.1 1390 5.6e-151 hypothetical protein TcasGA2_TC007517 [Tribolium castaneum] 821111045 XM_012524709.1 123 2.43172e-55 PREDICTED: Dasypus novemcinctus dynein heavy chain 1, axonemal-like (LOC101421502), partial mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q9P2D7 924 2.5e-98 Dynein heavy chain 1, axonemal OS=Homo sapiens GN=DNAH1 PE=2 SV=4 PF00270//PF02562//PF04851 DEAD/DEAH box helicase//PhoH-like protein//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- -- -- Cluster-16229.0 BP_3 2.00 0.50 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1623.0 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16232.0 BP_3 13.00 1.15 837 470455770 XP_004340994.1 206 7.0e-14 Zn-finger in Ran binding protein and others domain containing protein [Acanthamoeba castellanii str. Neff]>gi|440797856|gb|ELR18930.1| Zn-finger in Ran binding protein and others domain containing protein [Acanthamoeba castellanii str. Neff] -- -- -- -- -- -- -- -- -- P32770 124 9.3e-06 Asparagine-rich protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NRP1 PE=1 SV=2 PF06003//PF00301//PF00641//PF07562 Survival motor neuron protein (SMN)//Rubredoxin//Zn-finger in Ran binding protein and others//Nine Cysteines Domain of family 3 GPCR GO:0006397//GO:0007186 mRNA processing//G-protein coupled receptor signaling pathway GO:0004930//GO:0003723//GO:0008270//GO:0005506 G-protein coupled receptor activity//RNA binding//zinc ion binding//iron ion binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-1624.0 BP_3 1.00 1.20 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16241.0 BP_3 9.00 0.45 1254 478251147 ENN71623.1 971 2.1e-102 hypothetical protein YQE_11722, partial [Dendroctonus ponderosae]>gi|546685809|gb|ERL95252.1| hypothetical protein D910_12519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1625.0 BP_3 1.00 0.57 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16255.0 BP_3 2.00 0.33 580 646696939 KDR08903.1 794 3.2e-82 Protein stoned-B [Zootermopsis nevadensis] 195393115 XM_002055164.1 68 3.95866e-25 Drosophila virilis GJ18922 (Dvir\GJ18922), mRNA -- -- -- -- Q24212 728 5.9e-76 Protein stoned-B OS=Drosophila melanogaster GN=stnB PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2677 Stoned B synaptic vesicle biogenesis protein Cluster-16264.0 BP_3 6.30 0.42 1018 642912988 XP_008201341.1 231 1.1e-16 PREDICTED: uncharacterized protein LOC103315160 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1627.0 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16277.0 BP_3 4.00 0.38 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16283.0 BP_3 6.00 0.43 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16286.0 BP_3 7.00 0.47 1008 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-16288.0 BP_3 2.00 1.96 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16290.0 BP_3 5.00 0.78 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16293.2 BP_3 5.00 0.48 790 110734711 ABG88960.1 428 1.2e-39 elongation factor-1 gamma [Dolomedes tenebrosus] 697091158 XM_009660081.1 790 0 Verticillium dahliae VdLs.17 elongation factor 1-gamma 1 mRNA K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 P29547 515 4.0e-51 Elongation factor 1-gamma 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAM1 PE=1 SV=2 PF00647//PF04625 Elongation factor 1 gamma, conserved domain//DEC-1 protein, N-terminal region GO:0007304//GO:0006448//GO:0006414 chorion-containing eggshell formation//regulation of translational elongation//translational elongation GO:0003746//GO:0005213 translation elongation factor activity//structural constituent of chorion GO:0042600//GO:0005576//GO:0005840 chorion//extracellular region//ribosome KOG1627 Translation elongation factor EF-1 gamma Cluster-16295.0 BP_3 4.00 0.38 802 808858724 KKF11052.1 148 3.6e-07 Repetitive proline-rich cell wall protein 2 [Larimichthys crocea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-163.0 BP_3 3.00 0.67 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16302.0 BP_3 2.00 0.67 434 -- -- -- -- -- 697087029 XM_009658132.1 431 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16306.0 BP_3 4.00 0.38 796 332374070 AEE62176.1 295 3.2e-24 unknown [Dendroctonus ponderosae] -- -- -- -- -- K12259 SMOX, PAO5 spermine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K12259 Q9NWM0 180 2.9e-12 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01593//PF07825 Flavin containing amine oxidoreductase//Excisionase-like protein GO:0006310//GO:0055114 DNA recombination//oxidation-reduction process GO:0003677//GO:0016491 DNA binding//oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-16307.1 BP_3 2.00 0.46 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16309.0 BP_3 2.00 0.63 444 646721233 KDR22703.1 359 6.8e-32 Transcription factor BTF3-like protein 4 [Zootermopsis nevadensis] 697073630 XM_009653169.1 358 0 Verticillium dahliae VdLs.17 nascent polypeptide-associated complex subunit beta partial mRNA K01527 EGD1, BTF3 nascent polypeptide-associated complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01527 Q7SDU4 588 7.8e-60 Nascent polypeptide-associated complex subunit beta OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=npc-2 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2240 RNA polymerase II general transcription factor BTF3 and related proteins Cluster-16315.0 BP_3 7.00 0.57 879 642912160 XP_008200831.1 344 7.4e-30 PREDICTED: homeobox protein MOX-2 [Tribolium castaneum] 795108199 XM_012026605.1 53 1.33557e-16 PREDICTED: Vollenhovia emeryi homeobox protein MOX-2 (LOC105569842), mRNA K09322 MEOX, MOX homeobox protein MOX http://www.genome.jp/dbget-bin/www_bget?ko:K09322 P39020 317 4.1e-28 Homeobox protein MOX-2 OS=Rattus norvegicus GN=Meox2 PE=2 SV=1 PF00046//PF06056 Homeobox domain//Putative ATPase subunit of terminase (gpP-like) GO:0019069 viral capsid assembly GO:0005524//GO:0003677 ATP binding//DNA binding -- -- -- -- Cluster-1632.0 BP_3 12.00 1.79 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16320.0 BP_3 4.00 1.00 484 642925224 XP_008194474.1 214 4.8e-15 PREDICTED: uncharacterized protein LOC100142004 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16326.0 BP_3 3.00 0.31 753 558162012 XP_006123075.1 184 2.3e-11 PREDICTED: zinc finger protein 135-like isoform X1 [Pelodiscus sinensis] 768311759 CP010987.1 579 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence K09197 SP7 transcription factor Sp7 http://www.genome.jp/dbget-bin/www_bget?ko:K09197 Q29RK0 171 3.0e-11 Zinc finger protein 574 OS=Bos taurus GN=ZNF574 PE=2 SV=1 PF00096//PF13465//PF13912//PF06524//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//NOA36 protein//BED zinc finger -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-16329.0 BP_3 19.00 0.56 1922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16345.0 BP_3 2.00 0.33 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16346.0 BP_3 3.00 0.36 690 374094666 AEY84718.1 347 2.6e-30 YIPF3-like protein, partial [Pandalus platyceros] -- -- -- -- -- -- -- -- -- Q803Z2 184 8.5e-13 Protein YIPF3 OS=Danio rerio GN=yipf3 PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane -- -- Cluster-16353.0 BP_3 3.00 0.33 727 556757314 XP_005974002.1 471 1.1e-44 PREDICTED: 30S ribosomal protein S2, chloroplastic-like [Pantholops hodgsonii] 309321413 HQ336405.1 655 0 Prunus persica chloroplast, complete genome -- -- -- -- Q09FX2 1066 4.8e-115 30S ribosomal protein S2, chloroplastic OS=Nandina domestica GN=rps2 PE=3 SV=1 PF00318 Ribosomal protein S2 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0832 Mitochondrial/chloroplast ribosomal protein S2 Cluster-16354.0 BP_3 8.00 0.43 1193 347976440 XP_003436498.1 260 5.5e-20 AGAP003509-PE [Anopheles gambiae str. PEST]>gi|347976442|ref|XP_003436499.1| AGAP003509-PG [Anopheles gambiae str. PEST]>gi|333466646|gb|EGK96324.1| AGAP003509-PE [Anopheles gambiae str. PEST]>gi|333466649|gb|EGK96327.1| AGAP003509-PG [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- Q8IPM8 254 1.1e-20 Complexin OS=Drosophila melanogaster GN=cpx PE=2 SV=1 PF10186//PF05835 Vacuolar sorting 38 and autophagy-related subunit 14//Synaphin protein GO:0006836//GO:0010508 neurotransmitter transport//positive regulation of autophagy GO:0019905 syntaxin binding -- -- -- -- Cluster-16359.0 BP_3 2.44 0.68 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16359.1 BP_3 4.00 3.00 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16361.0 BP_3 14.00 0.44 1836 401429442 XP_003879203.1 1044 1.0e-110 putative calcium motive p-type ATPase [Leishmania mexicana MHOM/GT/2001/U1103]>gi|322495453|emb|CBZ30758.1| putative calcium motive p-type ATPase [Leishmania mexicana MHOM/GT/2001/U1103] 697068583 XM_009651181.1 1794 0 Verticillium dahliae VdLs.17 sodium transport ATPase partial mRNA K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 Q12691 1464 8.5e-161 Sodium transport ATPase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENA5 PE=1 SV=1 -- -- -- -- GO:0003824 catalytic activity -- -- KOG0202 Ca2+ transporting ATPase Cluster-16372.1 BP_3 4.00 0.31 915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16392.1 BP_3 7.00 14.15 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-164.0 BP_3 6.00 0.71 700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16400.0 BP_3 22.28 0.44 2758 817072965 XP_012258601.1 180 2.4e-10 PREDICTED: uncharacterized protein LOC105687494 isoform X2 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16403.0 BP_3 1.00 0.54 379 321475172 EFX86135.1 168 8.1e-10 hypothetical protein DAPPUDRAFT_313160 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q6PD31 131 6.5e-07 Trafficking kinesin-binding protein 1 OS=Mus musculus GN=Trak1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16412.0 BP_3 1.00 0.44 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16414.0 BP_3 9.00 0.44 1269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16416.1 BP_3 35.00 5.30 610 270008861 EFA05309.1 269 2.5e-21 hypothetical protein TcasGA2_TC015467 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5I0G3 126 4.0e-06 Putative malate dehydrogenase 1B OS=Homo sapiens GN=MDH1B PE=2 SV=1 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114 oxidation-reduction process GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- -- -- Cluster-16417.1 BP_3 1.00 0.34 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16418.0 BP_3 5.00 0.52 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16423.0 BP_3 1.00 0.32 442 321453855 EFX65054.1 537 1.5e-52 hypothetical protein DAPPUDRAFT_65729 [Daphnia pulex] 701434252 XM_010006711.1 35 6.55864e-07 PREDICTED: Chaetura pelagica solute carrier family 6 (neurotransmitter transporter, glycine), member 9 (SLC6A9), mRNA K05048 SLC6A15S solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20 http://www.genome.jp/dbget-bin/www_bget?ko:K05048 Q8VDB9 460 5.4e-45 Sodium- and chloride-dependent transporter XTRP3A OS=Mus musculus GN=Slc6a20a PE=2 SV=1 PF00209//PF01527 Sodium:neurotransmitter symporter family//Transposase GO:0006313//GO:0006836//GO:0006812 transposition, DNA-mediated//neurotransmitter transport//cation transport GO:0005328//GO:0004803//GO:0003677 neurotransmitter:sodium symporter activity//transposase activity//DNA binding GO:0016021 integral component of membrane -- -- Cluster-16432.0 BP_3 21.00 0.69 1766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16433.0 BP_3 3.00 1.24 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16434.0 BP_3 4.00 0.44 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16436.0 BP_3 7.00 0.34 1283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16438.1 BP_3 2.00 2.54 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16441.0 BP_3 1.00 0.32 442 260814835 XP_002602119.1 296 1.4e-24 hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae]>gi|229287425|gb|EEN58131.1| hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae] 761231940 KM881643.1 442 0 Oryza officinalis chloroplast, complete genome K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 P69443 368 2.5e-34 ATP synthase epsilon chain, chloroplastic OS=Triticum aestivum GN=atpE PE=3 SV=1 PF00306//PF02823 ATP synthase alpha/beta chain, C terminal domain//ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0015986//GO:0015992//GO:0005975//GO:0006119//GO:0015991 ATP synthesis coupled proton transport//proton transport//carbohydrate metabolic process//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046933//GO:0046961//GO:0008553//GO:0005524//GO:0016757//GO:0016820 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//hydrogen-exporting ATPase activity, phosphorylative mechanism//ATP binding//transferase activity, transferring glycosyl groups//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0045261//GO:0045259//GO:0033178 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex//proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-16444.0 BP_3 2.00 0.32 596 675383245 KFM76142.1 219 1.6e-15 Eukaryotic translation initiation factor 3 subunit J, partial [Stegodyphus mimosarum] -- -- -- -- -- K03245 EIF3J translation initiation factor 3 subunit J http://www.genome.jp/dbget-bin/www_bget?ko:K03245 A7RSH7 188 2.5e-13 Eukaryotic translation initiation factor 3 subunit J OS=Nematostella vectensis GN=v1g240395 PE=3 SV=1 PF08597 Translation initiation factor eIF3 subunit GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005852//GO:0005737//GO:0005840 eukaryotic translation initiation factor 3 complex//cytoplasm//ribosome KOG4813 Translation initiation factor eIF3, p35 subunit Cluster-16446.0 BP_3 2.00 0.60 453 470326429 XP_004364696.1 683 1.9e-69 ATP synthase subunit beta [Capsaspora owczarzaki ATCC 30864]>gi|765549898|gb|KJE90519.1| ATP synthase subunit beta [Capsaspora owczarzaki ATCC 30864] 768311755 CP010983.1 402 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 P23704 716 1.1e-74 ATP synthase subunit beta, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=atp-2 PE=2 SV=1 PF00006//PF00306 ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta chain, C terminal domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005524 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//ATP binding GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-16446.2 BP_3 3.00 0.32 748 551513237 XP_005808131.1 663 6.4e-67 PREDICTED: ATP synthase subunit beta, mitochondrial-like [Xiphophorus maculatus] 697081165 XM_009655770.1 663 0 Verticillium dahliae VdLs.17 ATP synthase subunit beta partial mRNA K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 P23704 804 1.2e-84 ATP synthase subunit beta, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=atp-2 PE=2 SV=1 PF02874//PF02367//PF00006 ATP synthase alpha/beta family, beta-barrel domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATP synthase alpha/beta family, nucleotide-binding domain GO:0015992//GO:0046034//GO:0002949 proton transport//ATP metabolic process//tRNA threonylcarbamoyladenosine modification GO:0005524 ATP binding -- -- KOG1350 F0F1-type ATP synthase, beta subunit Cluster-16448.0 BP_3 2.00 0.53 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16453.0 BP_3 2.00 0.31 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16466.0 BP_3 12.79 0.68 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16467.0 BP_3 7.00 0.81 709 71051661 AAH98550.1 431 4.9e-40 Ribosomal protein L23a [Danio rerio] 697088136 XM_009658684.1 654 0 Verticillium dahliae VdLs.17 60S ribosomal protein L23a partial mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 425 9.9e-41 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-16475.0 BP_3 7.00 1.05 614 -- -- -- -- -- 768311754 CP010982.1 374 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16482.0 BP_3 5.00 2.14 403 -- -- -- -- -- 315057124 HM345951.1 47 1.26628e-13 Scylla paramamosain arasin-like protein mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16488.0 BP_3 3.00 2.52 343 470290541 XP_004343156.1 189 2.7e-12 squalene monooxygenase [Capsaspora owczarzaki ATCC 30864]>gi|765557143|gb|KJE97437.1| squalene monooxygenase [Capsaspora owczarzaki ATCC 30864]>gi|765557144|gb|KJE97438.1| squalene monooxygenase, variant 1 [Capsaspora owczarzaki ATCC 30864]>gi|765557145|gb|KJE97439.1| squalene monooxygenase, variant 2 [Capsaspora owczarzaki ATCC 30864] 768311758 CP010986.1 340 1.40568e-176 Verticillium dahliae VdLs.17 chromosome 7, complete sequence K00511 SQLE, ERG1 squalene monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00511 P52019 165 6.7e-11 Squalene monooxygenase OS=Mus musculus GN=Sqle PE=2 SV=1 PF08491 Squalene epoxidase GO:0016114//GO:0006694//GO:0055114 terpenoid biosynthetic process//steroid biosynthetic process//oxidation-reduction process GO:0050660//GO:0004506 flavin adenine dinucleotide binding//squalene monooxygenase activity GO:0016021 integral component of membrane -- -- Cluster-1649.0 BP_3 2.78 0.52 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16492.0 BP_3 4.00 0.41 764 47086069 NP_998411.1 355 3.4e-31 voltage-dependent anion-selective channel protein 3 [Danio rerio]>gi|41107580|gb|AAH65468.1| Voltage-dependent anion channel 3 [Danio rerio] 697069520 XM_009651649.1 764 0 Verticillium dahliae VdLs.17 outer mitochondrial membrane protein porin mRNA K15041 VDAC3 voltage-dependent anion channel protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15041 P07144 1037 1.2e-111 Mitochondrial outer membrane protein porin OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=B7H23.070 PE=2 SV=1 PF01459 Eukaryotic porin GO:0055085//GO:0044699 transmembrane transport//single-organism process -- -- GO:0005741 mitochondrial outer membrane KOG3126 Porin/voltage-dependent anion-selective channel protein Cluster-16496.1 BP_3 8.00 0.33 1476 270011078 EFA07526.1 1133 4.0e-121 retinal homeobox [Tribolium castaneum] 530579900 XM_005283798.1 124 7.73846e-56 PREDICTED: Chrysemys picta bellii retina and anterior neural fold homeobox 2 (RAX2), mRNA K09332 RAX, RX retina and anterior neural fold homeobox protein http://www.genome.jp/dbget-bin/www_bget?ko:K09332 Q9W2Q1 489 7.8e-48 Retinal homeobox protein Rx OS=Drosophila melanogaster GN=Rx PE=2 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-16497.0 BP_3 1.00 0.32 444 759104135 XP_011352953.1 336 3.1e-29 PREDICTED: male-enhanced antigen 1 isoform X1 [Pteropus vampyrus] 767940077 XM_011514627.1 444 0 PREDICTED: Homo sapiens male-enhanced antigen 1 (MEA1), transcript variant X3, mRNA -- -- -- -- Q95313 333 2.9e-30 Male-enhanced antigen 1 OS=Sus scrofa GN=MEA1 PE=2 SV=2 PF06910 Male enhanced antigen 1 (MEA1) GO:0007283 spermatogenesis -- -- -- -- -- -- Cluster-16501.0 BP_3 2.00 0.43 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16502.0 BP_3 6.00 0.62 759 546677956 ERL88689.1 293 5.2e-24 hypothetical protein D910_06072 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-16506.0 BP_3 3.00 0.37 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16509.0 BP_3 15.00 0.50 1727 270002724 EEZ99171.1 541 2.1e-52 odorant receptor 59 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUK5 234 3.4e-18 Putative odorant receptor 71a OS=Drosophila melanogaster GN=Or71a PE=2 SV=4 PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016020 membrane -- -- Cluster-16519.0 BP_3 10.00 0.65 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16520.0 BP_3 3.00 0.52 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16521.0 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16523.0 BP_3 34.00 1.70 1256 383858571 XP_003704774.1 1353 1.1e-146 PREDICTED: 60S ribosomal protein L4 [Megachile rotundata] 543354349 XM_005521649.1 171 4.89272e-82 PREDICTED: Pseudopodoces humilis ribosomal protein L4 (RPL4), mRNA K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P08429 1324 1.0e-144 60S ribosomal protein L4-A OS=Xenopus laevis GN=rpl4-a PE=2 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-16523.1 BP_3 4.00 0.32 886 240957125 XP_002400083.1 737 2.0e-75 protein kinase pkn/prk1, effector, putative [Ixodes scapularis]>gi|215490655|gb|EEC00298.1| protein kinase pkn/prk1, effector, putative, partial [Ixodes scapularis] -- -- -- -- -- -- -- -- -- Q80U16 485 1.4e-47 Protein FAM65B OS=Mus musculus GN=Fam65b PE=1 SV=2 -- -- GO:0016310 phosphorylation GO:0016301//GO:0043890 kinase activity//N-acetylgalactosamine-6-sulfatase activity -- -- -- -- Cluster-16526.0 BP_3 2.00 0.39 542 665800085 XP_008547990.1 695 9.0e-71 PREDICTED: E3 ubiquitin-protein ligase HECTD1 isoform X2 [Microplitis demolitor] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q9ULT8 640 8.9e-66 E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens GN=HECTD1 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-16539.0 BP_3 4.00 7.90 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16540.0 BP_3 15.00 0.95 1054 91076058 XP_966616.1 1350 2.0e-146 PREDICTED: Bardet-Biedl syndrome 5 protein homolog [Tribolium castaneum]>gi|270014685|gb|EFA11133.1| hypothetical protein TcasGA2_TC004734 [Tribolium castaneum] -- -- -- -- -- K16748 BBS5 Bardet-Biedl syndrome 5 protein http://www.genome.jp/dbget-bin/www_bget?ko:K16748 Q7ZWB7 1016 4.3e-109 Bardet-Biedl syndrome 5 protein homolog OS=Danio rerio GN=bbs5 PE=2 SV=1 PF07289//PF11605 Protein of unknown function (DUF1448)//Vacuolar protein sorting protein 36 Vps36 -- -- GO:0032266//GO:0043130 phosphatidylinositol-3-phosphate binding//ubiquitin binding GO:0034464 BBSome -- -- Cluster-16545.0 BP_3 25.65 0.59 2376 642929986 XP_008196054.1 297 5.6e-24 PREDICTED: sodium channel protein Nach-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16551.0 BP_3 1.00 0.58 372 675366091 KFM58993.1 161 5.2e-09 hypothetical protein X975_20400, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16554.0 BP_3 1.00 1.27 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04420 CHD5-like protein GO:0071816 tail-anchored membrane protein insertion into ER membrane -- -- -- -- -- -- Cluster-16555.0 BP_3 7.00 0.55 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16558.0 BP_3 23.10 0.43 2895 546679820 ERL90212.1 1294 1.7e-139 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BQA5 823 2.9e-86 Histone H4 transcription factor OS=Homo sapiens GN=HINFP PE=1 SV=2 PF00096//PF13465//PF07823//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Cyclic phosphodiesterase-like protein//C2H2-type zinc finger -- -- GO:0004112//GO:0046872 cyclic-nucleotide phosphodiesterase activity//metal ion binding -- -- -- -- Cluster-16563.0 BP_3 3.00 0.63 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16569.0 BP_3 13.00 1.36 754 754341910 XP_004365052.2 316 1.1e-26 ribosomal protein L24 [Capsaspora owczarzaki ATCC 30864]>gi|765547919|gb|KJE88540.1| ribosomal protein L24 [Capsaspora owczarzaki ATCC 30864] 697073635 XM_009653171.1 751 0 Verticillium dahliae VdLs.17 60S ribosomal protein L24 mRNA K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q7SDU2 455 3.5e-44 60S ribosomal protein L24 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-24 PE=3 SV=1 PF00436//PF06189 Single-strand binding protein family//5'-nucleotidase GO:0009117 nucleotide metabolic process GO:0003697//GO:0000166//GO:0000287//GO:0008253 single-stranded DNA binding//nucleotide binding//magnesium ion binding//5'-nucleotidase activity GO:0005737 cytoplasm KOG1722 60s ribosomal protein L24 Cluster-1658.0 BP_3 2.00 0.39 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-166.0 BP_3 5.00 0.40 899 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16602.0 BP_3 1.00 0.64 364 -- -- -- -- -- 597569085 KF990036.1 364 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- Q9THV5 278 5.6e-24 DNA-directed RNA polymerase subunit beta'' OS=Sinapis alba GN=rpoC2 PE=1 SV=1 PF04983 RNA polymerase Rpb1, domain 3 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-16604.0 BP_3 42.00 1.37 1767 223585573 ACM91676.1 2245 5.5e-250 F1F0-ATP synthase beta subunit [Marsupenaeus japonicus] 329565547 JF303646.1 876 0 Penaeus monodon ATP synthase beta subunit mRNA, complete cds K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q05825 1990 8.3e-222 ATP synthase subunit beta, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-beta PE=1 SV=3 PF00931//PF03193//PF00005//PF00006//PF01637//PF00004//PF02874//PF00306 NB-ARC domain//Protein of unknown function, DUF258//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//ATP synthase alpha/beta family, beta-barrel domain//ATP synthase alpha/beta chain, C terminal domain GO:0015991//GO:0046034//GO:0015992 ATP hydrolysis coupled proton transport//ATP metabolic process//proton transport GO:0016820//GO:0003924//GO:0043531//GO:0005524//GO:0016887//GO:0005525 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//GTPase activity//ADP binding//ATP binding//ATPase activity//GTP binding GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-16605.0 BP_3 6.53 0.32 1261 225712314 ACO12003.1 998 1.5e-105 Transposable element Tc3 transposase [Lepeophtheirus salmonis] 3676297 U97104.1 382 0 BTU97104 Bactrocera tryoni membrane transporter (white) gene, complete cds -- -- -- -- -- -- -- -- PF01527 Transposase GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-16607.1 BP_3 2.00 0.54 471 642938512 XP_008195463.1 463 6.2e-44 PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum]>gi|642938514|ref|XP_008195504.1| PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00591 COQ3 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00591 Q63159 354 1.1e-32 Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Rattus norvegicus GN=Coq3 PE=2 SV=2 PF09445//PF01209//PF05401//PF01555//PF05175//PF05891//PF08241 RNA cap guanine-N2 methyltransferase//ubiE/COQ5 methyltransferase family//Nodulation protein S (NodS)//DNA methylase//Methyltransferase small domain//AdoMet dependent proline di-methyltransferase//Methyltransferase domain GO:0009452//GO:0008152//GO:0009312//GO:0001510//GO:0009877//GO:0006480//GO:0006306 7-methylguanosine RNA capping//metabolic process//oligosaccharide biosynthetic process//RNA methylation//nodulation//N-terminal protein amino acid methylation//DNA methylation GO:0008757//GO:0003677//GO:0008168//GO:0008170 S-adenosylmethionine-dependent methyltransferase activity//DNA binding//methyltransferase activity//N-methyltransferase activity -- -- KOG1270 Methyltransferases Cluster-16621.0 BP_3 2.62 0.50 545 -- -- -- -- -- 404312705 AC253545.1 535 0 Prunus persica clone JGIBIXB-13E11, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16623.0 BP_3 5.00 0.89 563 161661015 ABX75375.1 578 3.5e-57 60S ribosomal protein L13A [Lycosa singoriensis] 697082146 XM_009656109.1 563 0 Verticillium dahliae VdLs.17 60S ribosomal protein L16 partial mRNA K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 Q9P720 755 4.3e-79 60S ribosomal protein L16 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=crp-46 PE=3 SV=1 PF00572 Ribosomal protein L13 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-16623.1 BP_3 6.00 0.56 809 -- -- -- -- -- 768311756 CP010984.1 754 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- Q9P720 174 1.4e-11 60S ribosomal protein L16 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=crp-46 PE=3 SV=1 PF03504 Chlamydia cysteine-rich outer membrane protein 6 -- -- GO:0005201 extracellular matrix structural constituent GO:0005578 proteinaceous extracellular matrix KOG3204 60S ribosomal protein L13a Cluster-16637.0 BP_3 3.00 0.44 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16638.0 BP_3 2.00 0.43 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16639.0 BP_3 1.00 0.88 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16643.0 BP_3 1.00 0.65 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01104 Bunyavirus non-structural protein NS-s GO:0016032 viral process -- -- -- -- -- -- Cluster-16651.0 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16654.0 BP_3 2.00 1.35 359 -- -- -- -- -- 325260834 HM999008.1 350 0 Oryza nivara clone BAC ORBBa0014L06, complete sequence -- -- -- -- -- -- -- -- PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-16654.2 BP_3 2.00 0.46 503 -- -- -- -- -- 38637384 AP005491.3 442 0 Oryza sativa Japonica Group genomic DNA, chromosome 8, BAC clone:OSJNBa0062G05 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16654.3 BP_3 7.00 0.44 1051 -- -- -- -- -- 90399338 AL117265.3 981 0 Oryza sativa genomic DNA, chromosome 4, BAC clone: H0811D08, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16654.4 BP_3 2.00 0.41 529 -- -- -- -- -- 61656658 AL731594.5 505 0 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSJNBa0032N05, complete sequence -- -- -- -- -- -- -- -- PF04995 Heme exporter protein D (CcmD) GO:0017004//GO:0015886 cytochrome complex assembly//heme transport -- -- GO:0016021 integral component of membrane -- -- Cluster-16656.0 BP_3 9.00 0.90 775 642933168 XP_008197285.1 218 2.6e-15 PREDICTED: intracellular protein transport protein USO1-like [Tribolium castaneum]>gi|270012548|gb|EFA08996.1| hypothetical protein TcasGA2_TC006703 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702 Fibrinogen alpha/beta chain family GO:0051258//GO:0030168//GO:0007165 protein polymerization//platelet activation//signal transduction GO:0005102//GO:0030674 receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-16657.0 BP_3 1.00 0.32 441 262306583 ACY45884.1 609 6.9e-61 AMP deaminase, partial [Lynceus sp. 'Lyn'] 617631450 XM_007529342.1 84 3.77399e-34 PREDICTED: Erinaceus europaeus adenosine monophosphate deaminase 2 (AMPD2), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q02356 558 2.3e-56 AMP deaminase 2 OS=Rattus norvegicus GN=Ampd2 PE=2 SV=2 PF00578//PF00962 AhpC/TSA family//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0016491//GO:0019239//GO:0016209 oxidoreductase activity//deaminase activity//antioxidant activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-16660.0 BP_3 1.00 0.46 396 -- -- -- -- -- 58197543 AP008246.1 369 0 Oryza sativa Japonica Group genomic DNA, chromosome 1, BAC clone:B1642C07 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16663.0 BP_3 1.00 0.43 403 703624008 AIW42687.1 485 1.5e-46 phospholipid-hydroperoxide glutathione peroxidase [Scylla paramamosain] 703624007 KM275218.1 341 4.66477e-177 Scylla paramamosain phospholipid-hydroperoxide glutathione peroxidase mRNA, complete cds K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q9N2J2 320 8.4e-29 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial OS=Bos taurus GN=GPX4 PE=2 SV=2 PF00255 Glutathione peroxidase GO:0006804//GO:0055114//GO:0006979//GO:0006749 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress//glutathione metabolic process GO:0004602 glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-16663.1 BP_3 2.00 0.39 542 586852008 AHJ86274.1 342 7.7e-30 phospholipid glutathione peroxidase, partial [Macrophthalmus japonicus] 703624007 KM275218.1 182 1.56303e-88 Scylla paramamosain phospholipid-hydroperoxide glutathione peroxidase mRNA, complete cds K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q00277 223 2.0e-17 Glutathione peroxidase OS=Schistosoma mansoni GN=GPX1 PE=1 SV=2 PF00255 Glutathione peroxidase GO:0006749//GO:0006804//GO:0055114//GO:0006979 glutathione metabolic process//obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress GO:0004602 glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-16664.0 BP_3 4.00 0.88 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16670.0 BP_3 2.00 0.32 591 308497244 XP_003110809.1 165 2.8e-09 hypothetical protein CRE_04678 [Caenorhabditis remanei]>gi|308242689|gb|EFO86641.1| hypothetical protein CRE_04678 [Caenorhabditis remanei] 768311757 CP010985.1 591 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- Q9P8W3 809 2.4e-85 Zinc finger transcription factor ace1 OS=Hypocrea jecorina GN=ace1 PE=3 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-16671.0 BP_3 8.00 0.42 1218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16672.0 BP_3 1.00 0.40 411 269995919 NP_001161782.1 502 1.6e-48 yellow-g2 precursor [Tribolium castaneum]>gi|264666908|gb|ACY71061.1| yellow-g2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16679.0 BP_3 5.00 0.40 895 478250136 ENN70639.1 368 1.2e-32 hypothetical protein YQE_12584, partial [Dendroctonus ponderosae]>gi|546673430|gb|ERL85038.1| hypothetical protein D910_02461 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P85828 360 4.3e-33 Prohormone-3 OS=Apis mellifera PE=1 SV=1 PF00095//PF04706 WAP-type (Whey Acidic Protein) 'four-disulfide core'//Dickkopf N-terminal cysteine-rich region GO:0007275//GO:0030178 multicellular organismal development//negative regulation of Wnt signaling pathway GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-16686.0 BP_3 3.00 0.85 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16691.0 BP_3 3.00 0.35 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-167.0 BP_3 19.00 1.67 841 642911853 XP_008200773.1 381 3.6e-34 PREDICTED: uncharacterized protein LOC103315002 [Tribolium castaneum]>gi|270014708|gb|EFA11156.1| hypothetical protein TcasGA2_TC004760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16701.1 BP_3 4.00 0.75 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16702.0 BP_3 1.00 0.34 435 242000104 XP_002434695.1 588 1.9e-58 ribosome biogenesis protein - Nop58p/Nop5p, putative [Ixodes scapularis]>gi|215498025|gb|EEC07519.1| ribosome biogenesis protein - Nop58p/Nop5p, putative [Ixodes scapularis] -- -- -- -- -- K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q3SZ63 565 3.6e-57 Nucleolar protein 56 OS=Bos taurus GN=NOP56 PE=2 SV=1 PF10596 U6-snRNA interacting domain of PrP8 -- -- GO:0017070 U6 snRNA binding -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-16707.0 BP_3 2.00 1.04 382 -- -- -- -- -- 697075455 XM_009653812.1 379 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16716.0 BP_3 3.00 0.35 704 -- -- -- -- -- 768311757 CP010985.1 692 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- PF04055 Radical SAM superfamily -- -- GO:0051536//GO:0003824 iron-sulfur cluster binding//catalytic activity -- -- -- -- Cluster-16719.0 BP_3 3.00 0.37 682 401757801 AFQ00928.1 974 5.1e-103 V-ATPase subunit D [Locusta migratoria] 262401038 FJ774700.1 415 0 Scylla paramamosain vacuolar ATP synthase subunit d 1-like protein mRNA, complete cds K02146 ATPeV0D, ATP6D V-type H+-transporting ATPase subunit d http://www.genome.jp/dbget-bin/www_bget?ko:K02146 Q25531 963 3.9e-103 V-type proton ATPase subunit d OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2957 Vacuolar H+-ATPase V0 sector, subunit d Cluster-16728.0 BP_3 3.00 0.41 646 242005783 XP_002423740.1 678 1.0e-68 protein singed, putative [Pediculus humanus corporis]>gi|212506942|gb|EEB11002.1| protein singed, putative [Pediculus humanus corporis] 768421387 XM_011553200.1 105 1.19928e-45 PREDICTED: Plutella xylostella protein singed (LOC105383184), mRNA K17455 FSCN1_2 fascin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17455 Q24524 655 1.9e-67 Protein singed OS=Drosophila melanogaster GN=sn PE=3 SV=1 PF06268//PF00167 Fascin domain//Fibroblast growth factor GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0030674//GO:0008083//GO:0051015 protein binding, bridging//growth factor activity//actin filament binding -- -- -- -- Cluster-16733.0 BP_3 4.00 0.49 684 260594183 ACX46386.1 421 6.7e-39 prepro-calcitonin-like diuretic hormone [Homarus americanus] -- -- -- -- -- -- -- -- -- Q9VLK4 198 2.0e-14 Diuretic hormone class 2 OS=Drosophila melanogaster GN=Dh31 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16738.0 BP_3 8.00 0.39 1285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16741.0 BP_3 7.00 0.36 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16743.0 BP_3 1.00 0.34 434 591373737 XP_007061563.1 663 3.7e-67 PREDICTED: elongation factor 1-alpha 1 [Chelonia mydas]>gi|465975678|gb|EMP34197.1| Elongation factor 1-alpha 1 [Chelonia mydas] 397781879 JQ314400.1 360 0 Pyrenophora teres f. maculata elongation factor-1a (EF-1a) gene, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q01765 718 6.4e-75 Elongation factor 1-alpha OS=Podospora curvicolla GN=TEF PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-16744.0 BP_3 3.00 0.53 567 646706756 KDR13833.1 139 2.8e-06 hypothetical protein L798_12012 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00093//PF02459 von Willebrand factor type C domain//Adenoviral DNA terminal protein GO:0006260 DNA replication GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-16745.0 BP_3 6.48 0.45 985 641657806 XP_008180482.1 228 2.3e-16 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16748.0 BP_3 3.00 0.51 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16749.0 BP_3 2.00 0.42 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16751.0 BP_3 2.00 0.35 566 321473863 EFX84829.1 679 6.8e-69 hypothetical protein DAPPUDRAFT_46385 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q9U1M2 634 4.6e-65 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-16754.0 BP_3 19.00 2.92 605 506965582 AGM32143.1 773 9.1e-80 60S ribosomal protein L11 [Coptotermes formosanus] 884959036 XM_010900292.2 188 8.11632e-92 PREDICTED: Esox lucius ribosomal protein L11 (rpl11), transcript variant X1, mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 Q94300 734 1.2e-76 60S ribosomal protein L11 OS=Caenorhabditis elegans GN=rpl-11.1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-16758.0 BP_3 2.00 0.35 568 91091362 XP_972603.1 449 3.2e-42 PREDICTED: uncharacterized protein LOC661347 [Tribolium castaneum]>gi|270014346|gb|EFA10794.1| hypothetical protein TcasGA2_TC012859 [Tribolium castaneum] -- -- -- -- -- K03962 NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03962 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16759.0 BP_3 3.00 1.34 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16762.0 BP_3 2.00 0.41 529 4507593 NP_003801.1 934 1.7e-98 tumor necrosis factor ligand superfamily member 10 isoform 1 [Homo sapiens]>gi|1730015|sp|P50591.1|TNF10_HUMAN RecName: Full=Tumor necrosis factor ligand superfamily member 10; AltName: Full=Apo-2 ligand; Short=Apo-2L; AltName: Full=TNF-related apoptosis-inducing ligand; Short=Protein TRAIL; AltName: CD_antigen=CD253>gi|1149558|gb|AAC50332.1| TNF-related apoptosis inducing ligand TRAIL [Homo sapiens]>gi|1336208|gb|AAB01233.1| Apo-2 ligand [Homo sapiens]>gi|21619748|gb|AAH32722.1| Tumor necrosis factor (ligand) superfamily, member 10 [Homo sapiens]>gi|48145907|emb|CAG33176.1| TNFSF10 [Homo sapiens]>gi|54695998|gb|AAV38371.1| tumor necrosis factor (ligand) superfamily, member 10 [Homo sapiens]>gi|117606468|gb|ABK41891.1| tumor necrosis factor (ligand) family, member 10 [Homo sapiens]>gi|119598871|gb|EAW78465.1| tumor necrosis factor (ligand) superfamily, member 10, isoform CRA_a [Homo sapiens]>gi|123979940|gb|ABM81799.1| tumor necrosis factor (ligand) superfamily, member 10 [synthetic construct]>gi|123994707|gb|ABM84955.1| tumor necrosis factor (ligand) superfamily, member 10 [synthetic construct]>gi|189053446|dbj|BAG35612.1| unnamed protein product [Homo sapiens]>gi|307684878|dbj|BAJ20479.1| tumor necrosis factor (ligand) superfamily, member 10 [synthetic construct]>gi|649122297|gb|AIC55464.1| TNFSF10, partial [synthetic construct] 649122296 KJ897900.1 529 0 Synthetic construct Homo sapiens clone ccsbBroadEn_07294 TNFSF10 gene, encodes complete protein K04721 TNFSF10, TRAIL tumor necrosis factor ligand superfamily member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K04721 P50591 934 7.0e-100 Tumor necrosis factor ligand superfamily member 10 OS=Homo sapiens GN=TNFSF10 PE=1 SV=1 PF00229 TNF(Tumour Necrosis Factor) family GO:0007165//GO:0007267//GO:2001238//GO:0006919//GO:0006955//GO:0090200//GO:0043123 signal transduction//cell-cell signaling//positive regulation of extrinsic apoptotic signaling pathway//activation of cysteine-type endopeptidase activity involved in apoptotic process//immune response//positive regulation of release of cytochrome c from mitochondria//positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0005125//GO:0005164//GO:0046872 cytokine activity//tumor necrosis factor receptor binding//metal ion binding GO:0005887//GO:0016020//GO:0005615 integral component of plasma membrane//membrane//extracellular space -- -- Cluster-16768.0 BP_3 9.28 0.50 1186 642922086 XP_008193011.1 301 9.6e-25 PREDICTED: cuticle protein 21-like [Tribolium castaneum]>gi|270007255|gb|EFA03703.1| hypothetical protein TcasGA2_TC013808 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81225 186 8.6e-13 Cuticle protein 21 OS=Locusta migratoria GN=ACP21 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-16771.0 BP_3 1.00 0.74 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16776.0 BP_3 3.00 0.33 736 -- -- -- -- -- 697069422 XM_009651600.1 661 0 Verticillium dahliae VdLs.17 ecm33 mRNA -- -- -- -- Q4WNS8 202 7.4e-15 Protein ecm33 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=ecm33 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16782.0 BP_3 2.00 0.49 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16787.0 BP_3 5.00 0.39 902 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1679.0 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16791.0 BP_3 4.00 0.84 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16792.0 BP_3 7.00 0.34 1295 270015467 EFA11915.1 438 1.4e-40 hypothetical protein TcasGA2_TC004072 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90218 133 1.3e-06 Probable glutamate receptor OS=Anas platyrhynchos GN=KBP PE=2 SV=1 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-16796.0 BP_3 1.00 1.97 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16796.1 BP_3 11.00 0.93 863 641656069 XP_008179833.1 232 7.0e-17 PREDICTED: tigger transposable element-derived protein 6-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q17RP2 181 2.4e-12 Tigger transposable element-derived protein 6 OS=Homo sapiens GN=TIGD6 PE=2 SV=2 PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-168.0 BP_3 13.61 0.77 1144 642920408 XP_008192335.1 310 8.4e-26 PREDICTED: putative lysozyme-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16806.0 BP_3 4.00 0.35 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16823.0 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16825.0 BP_3 3.00 0.39 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16827.0 BP_3 12.00 0.65 1186 642920523 XP_008192386.1 1149 4.5e-123 PREDICTED: cytoplasmic dynein 2 heavy chain 1 [Tribolium castaneum] -- -- -- -- -- K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q27802 642 1.1e-65 Cytoplasmic dynein 2 heavy chain 1 OS=Tripneustes gratilla GN=DYH1B PE=2 SV=2 PF08802//PF01424 Cytochrome B6-F complex Fe-S subunit//R3H domain GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0003676//GO:0009496//GO:0051537 nucleic acid binding//plastoquinol--plastocyanin reductase activity//2 iron, 2 sulfur cluster binding GO:0009512//GO:0042651 cytochrome b6f complex//thylakoid membrane KOG3595 Dyneins, heavy chain Cluster-16829.0 BP_3 6.48 0.54 868 -- -- -- -- -- 768311757 CP010985.1 281 2.37396e-143 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1683.0 BP_3 11.00 0.64 1124 676486009 XP_009063839.1 324 2.0e-27 hypothetical protein LOTGIDRAFT_155085 [Lottia gigantea]>gi|556096946|gb|ESO85598.1| hypothetical protein LOTGIDRAFT_155085 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16835.0 BP_3 2.00 0.77 416 344246100 EGW02204.1 257 4.3e-20 hypothetical protein I79_011772 [Cricetulus griseus] 694910257 XM_009448814.1 416 0 PREDICTED: Pan troglodytes brain abundant, membrane attached signal protein 1 (BASP1), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16838.0 BP_3 5.00 0.36 964 321476616 EFX87576.1 1255 1.9e-135 hypothetical protein DAPPUDRAFT_42792 [Daphnia pulex] 442623117 NM_165747.4 152 1.35987e-71 Drosophila melanogaster phosphofructokinase (Pfk), transcript variant C, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 1166 1.6e-126 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365//PF00184 Phosphofructokinase//Neurohypophysial hormones, C-terminal Domain GO:0006096//GO:0006098//GO:0006012//GO:0006013//GO:0006000//GO:0006094//GO:0007218 glycolytic process//pentose-phosphate shunt//galactose metabolic process//mannose metabolic process//fructose metabolic process//gluconeogenesis//neuropeptide signaling pathway GO:0005185//GO:0003872 neurohypophyseal hormone activity//6-phosphofructokinase activity GO:0005945//GO:0005576 6-phosphofructokinase complex//extracellular region KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-16844.0 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16847.0 BP_3 4.00 3.56 339 -- -- -- -- -- 768311752 CP010980.1 339 4.99049e-176 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16849.0 BP_3 3.00 0.39 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1685.0 BP_3 1.00 34.30 214 795020598 XP_011859977.1 133 5.2e-06 PREDICTED: uncharacterized protein LOC105557368 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16852.0 BP_3 2.00 0.33 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16853.0 BP_3 2.00 0.89 398 544463100 XP_005567901.1 591 7.6e-59 PREDICTED: immunoglobulin lambda-like polypeptide 5-like isoform X3 [Macaca fascicularis] 186134 M75282.1 362 0 HUMIGLDS Human Ig lambda L chain subgroup II V-2.DS mRNA, VJ region, partial cds >gnl|BL_ORD_ID|38026 Human Ig rearranged lambda chain (V-lambda-2.DS) mRNA, V-, J-, and C-region subgroup II -- -- -- -- P04209 458 8.3e-45 Ig lambda chain V-II region NIG-84 OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16854.1 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16864.0 BP_3 27.00 4.10 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16865.1 BP_3 2.00 0.55 468 752897932 XP_011267297.1 193 1.3e-12 PREDICTED: transmembrane and TPR repeat-containing protein CG4341 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q8N394 158 5.9e-10 Transmembrane and TPR repeat-containing protein 2 OS=Homo sapiens GN=TMTC2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16876.0 BP_3 5.00 0.42 872 761907738 XP_011403421.1 1228 2.3e-132 PREDICTED: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial-like [Amphimedon queenslandica] 697071276 XM_009652346.1 872 0 Verticillium dahliae VdLs.17 NADH-ubiquinone oxidoreductase 51 kDa subunit partial mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 P24917 1470 8.1e-162 NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=nuo-51 PE=2 SV=2 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region -- -- GO:0051539 4 iron, 4 sulfur cluster binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-16878.0 BP_3 5.00 0.39 914 831770499 XP_012753020.1 419 1.5e-38 hypothetical protein SAMD00019534_071590 [Acytostelium subglobosum LB1]>gi|735853652|dbj|GAM23984.1| hypothetical protein SAMD00019534_071590 [Acytostelium subglobosum LB1] 675324087 CP009075.1 902 0 Verticillium dahliae JR2 chromosome 1, complete sequence -- -- -- -- Q9Y8H5 478 9.1e-47 Delta(12) fatty acid desaturase OS=Mortierella alpina PE=1 SV=2 PF11960//PF00487 Domain of unknown function (DUF3474)//Fatty acid desaturase GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water -- -- -- -- Cluster-16879.0 BP_3 8.00 0.61 926 152013691 ABS19961.1 249 8.0e-19 selenoprotein W2 [Artemia franciscana] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08103 Uperin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-16884.0 BP_3 4.00 0.36 829 861581037 KMQ82156.1 161 1.1e-08 hypothetical protein RF55_23987 [Lasius niger] -- -- -- -- -- -- -- -- -- Q91G88 143 5.8e-08 Putative KilA-N domain-containing protein 006L OS=Invertebrate iridescent virus 6 GN=IIV6-006L PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-1689.0 BP_3 4.00 0.62 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16896.0 BP_3 7.00 0.51 956 -- -- -- -- -- 697076373 XM_009654119.1 946 0 Verticillium dahliae VdLs.17 extracellular cell wall glucanase Crf1 mRNA -- -- -- -- Q5AFA2 196 4.8e-14 Extracellular glycosidase CRH11 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CRH11 PE=1 SV=1 PF15180 Neuropeptides B and W GO:0007165 signal transduction GO:0001664 G-protein coupled receptor binding -- -- -- -- Cluster-169.0 BP_3 4.00 0.95 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16901.0 BP_3 10.00 0.42 1446 752882857 XP_011259103.1 178 2.2e-10 PREDICTED: uncharacterized protein LOC105253043 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16901.1 BP_3 4.00 1.62 410 755859970 XP_011290423.1 202 1.0e-13 PREDICTED: putative nuclease HARBI1 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16903.0 BP_3 3.00 0.35 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16907.2 BP_3 3.00 0.53 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00649 Copper fist DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005507//GO:0003677 transcription factor activity, sequence-specific DNA binding//copper ion binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-16907.3 BP_3 1.00 0.36 425 795063690 XP_011873777.1 224 2.9e-16 PREDICTED: probable G-protein coupled receptor 125 isoform X2 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF06016 GPCR proteolysis site, GPS, motif//Reovirus core-spike protein lambda-2 (L2) GO:0006370//GO:0009451 7-methylguanosine mRNA capping//RNA modification GO:0005524//GO:0004482//GO:0004484 ATP binding//mRNA (guanine-N7-)-methyltransferase activity//mRNA guanylyltransferase activity GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-16912.0 BP_3 5.00 0.56 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060 Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-16914.1 BP_3 19.01 0.49 2166 242008101 XP_002424851.1 301 1.8e-24 Y box binding protein, putative [Pediculus humanus corporis]>gi|212508401|gb|EEB12113.1| Y box binding protein, putative [Pediculus humanus corporis] 385724703 JQ772110.1 360 0 Cherax quadricarinatus cold shock Y-box protein mRNA, complete cds K09276 YBX1, NSEP1 Y-box-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09276 P62961 273 1.3e-22 Nuclease-sensitive element-binding protein 1 OS=Rattus norvegicus GN=Ybx1 PE=2 SV=3 PF00313 'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-16915.0 BP_3 2.00 0.33 587 830003785 XP_012576884.1 982 5.1e-104 PREDICTED: transducin-like enhancer protein 1 isoform X1 [Condylura cristata] 817211812 XM_012426638.1 357 0 PREDICTED: Orussus abietinus protein groucho-1-like (LOC105700617), transcript variant X3, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 Q04724 981 2.8e-105 Transducin-like enhancer protein 1 OS=Homo sapiens GN=TLE1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-16921.0 BP_3 1.00 0.34 435 642925224 XP_008194474.1 155 3.0e-08 PREDICTED: uncharacterized protein LOC100142004 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16922.0 BP_3 11.00 0.32 1960 225713362 ACO12527.1 412 2.1e-37 Dual specificity protein phosphatase 3 [Lepeophtheirus salmonis] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q6B8I0 349 1.8e-31 Dual specificity protein phosphatase 13 isoform A OS=Mus musculus GN=Dusp13 PE=2 SV=1 PF00102//PF00782//PF04179 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Initiator tRNA phosphoribosyl transferase GO:0019988//GO:0006570//GO:0006470 charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138//GO:0043399 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity -- -- KOG1716 Dual specificity phosphatase Cluster-16923.0 BP_3 5.00 0.50 773 766925539 XP_011494669.1 517 5.6e-50 PREDICTED: protein D3-like isoform X2 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- O16264 425 1.1e-40 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-16930.0 BP_3 17.03 0.82 1288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16941.0 BP_3 6.00 0.59 783 242011117 XP_002426302.1 810 6.1e-84 triosephosphate isomerase, putative [Pediculus humanus corporis]>gi|212510370|gb|EEB13564.1| triosephosphate isomerase, putative [Pediculus humanus corporis] 697079754 XM_009655288.1 738 0 Verticillium dahliae VdLs.17 triosephosphate isomerase partial mRNA K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 Q7S2Z9 932 1.8e-99 Triosephosphate isomerase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=tpi-1 PE=3 SV=1 PF00121 Triosephosphate isomerase GO:0006006//GO:0008152//GO:0006096//GO:0006020//GO:0006094//GO:0015976//GO:0006000//GO:0046486//GO:0006013 glucose metabolic process//metabolic process//glycolytic process//inositol metabolic process//gluconeogenesis//carbon utilization//fructose metabolic process//glycerolipid metabolic process//mannose metabolic process GO:0004807//GO:0016853 triose-phosphate isomerase activity//isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-16943.0 BP_3 3.00 0.55 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16945.0 BP_3 6.00 0.45 932 312986079 ADR31352.1 365 2.9e-32 gamma-interferon-inducible lysosomal thiol reductase [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- P13284 204 5.5e-15 Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens GN=IFI30 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-1695.0 BP_3 2.00 0.65 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16952.0 BP_3 4.00 0.32 897 478263786 ENN82065.1 294 4.7e-24 hypothetical protein YQE_01557, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q95SX7 200 1.5e-14 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF05195 Aminopeptidase P, N-terminal domain -- -- GO:0030145//GO:0004177 manganese ion binding//aminopeptidase activity -- -- -- -- Cluster-16954.0 BP_3 5.00 1.23 488 -- -- -- -- -- 768311752 CP010980.1 473 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16955.0 BP_3 12.00 0.50 1439 -- -- -- -- -- 697068361 XM_009651070.1 1433 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- A8Y4B2 134 1.1e-06 E3 ubiquitin-protein ligase hrd-1 OS=Caenorhabditis briggsae GN=sel-11 PE=3 SV=2 PF11789//PF13639//PF17123//PF12678//PF14634//PF12861//PF00097 Zinc-finger of the MIZ type in Nse subunit//Ring finger domain//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//metal ion binding//protein binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-16970.0 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16973.0 BP_3 2.00 0.32 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16977.1 BP_3 7.00 0.32 1362 646714771 KDR18625.1 1155 1.0e-123 Flotillin-1 [Zootermopsis nevadensis] -- -- -- -- -- K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61491 1110 7.1e-120 Flotillin-1 OS=Drosophila melanogaster GN=Flo-1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2668 Flotillins Cluster-16992.0 BP_3 2.00 0.53 474 795072692 XP_011838539.1 520 1.5e-50 PREDICTED: B-cell antigen receptor complex-associated protein alpha chain isoform X1 [Mandrillus leucophaeus]>gi|795398712|ref|XP_011942281.1| PREDICTED: B-cell antigen receptor complex-associated protein alpha chain [Cercocebus atys] 109731388 BC113733.1 470 0 Homo sapiens CD79a molecule, immunoglobulin-associated alpha, mRNA (cDNA clone MGC:142293 IMAGE:8322785), complete cds >gnl|BL_ORD_ID|3147336 Homo sapiens CD79a molecule, immunoglobulin-associated alpha, mRNA (cDNA clone MGC:142291 IMAGE:8322783), complete cds K06506 CD79A, IGA CD79A antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06506 P11912 520 6.4e-52 B-cell antigen receptor complex-associated protein alpha chain OS=Homo sapiens GN=CD79A PE=1 SV=2 PF02189 Immunoreceptor tyrosine-based activation motif GO:0007166//GO:0007165 cell surface receptor signaling pathway//signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-16998.0 BP_3 1.00 0.35 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17.0 BP_3 9.00 1.74 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-170.0 BP_3 3.00 0.53 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17004.0 BP_3 2.00 0.81 410 -- -- -- -- -- 50509864 AP006460.4 401 0 Oryza sativa Japonica Group genomic DNA, chromosome 7, BAC clone:OSJNBb0003M19 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17010.0 BP_3 3.00 0.52 569 805819675 XP_012149959.1 135 8.2e-06 PREDICTED: uncharacterized protein LOC100882345 [Megachile rotundata]>gi|805819677|ref|XP_012149960.1| PREDICTED: uncharacterized protein LOC100882345 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17012.0 BP_3 7.00 0.54 913 742106223 XP_010870816.1 208 4.5e-14 PREDICTED: hemicentin-1 [Esox lucius] -- -- -- -- -- K17341 HMCN hemicentin http://www.genome.jp/dbget-bin/www_bget?ko:K17341 P97300 202 9.2e-15 Neuroplastin OS=Mus musculus GN=Nptn PE=1 SV=3 PF07354//PF13895 Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain GO:0007339 binding of sperm to zona pellucida GO:0005515 protein binding GO:0005576 extracellular region KOG4475 FOG: Immunoglobin and related proteins Cluster-17014.0 BP_3 2.00 0.52 476 646697159 KDR09020.1 548 8.8e-54 TOM1-like protein 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6ZVM7 418 4.3e-40 TOM1-like protein 2 OS=Homo sapiens GN=TOM1L2 PE=1 SV=1 PF00790 VHS domain GO:0006886 intracellular protein transport -- -- -- -- KOG1087 Cytosolic sorting protein GGA2/TOM1 Cluster-17026.0 BP_3 2.00 0.35 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17035.0 BP_3 11.65 0.77 1022 478253033 ENN73413.1 1210 3.3e-130 hypothetical protein YQE_09975, partial [Dendroctonus ponderosae] 542171599 XM_005467190.1 51 2.02004e-15 PREDICTED: Oreochromis niloticus ATP-binding cassette sub-family A member 1-like (LOC100699821), transcript variant X3, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 847 1.7e-89 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF13304//PF00005//PF12179 AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//I-kappa-kinase-beta NEMO binding domain GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0016887//GO:0008384//GO:0005524 ATPase activity//IkappaB kinase activity//ATP binding GO:0008385 IkappaB kinase complex KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-17036.0 BP_3 6.00 0.60 771 209736122 ACI68930.1 569 5.2e-56 Translationally-controlled tumor protein homolog [Salmo salar] 697075476 XM_009653822.1 759 0 Verticillium dahliae VdLs.17 translationally-controlled tumor protein mRNA -- -- -- -- Q4IJT5 565 6.3e-57 Translationally-controlled tumor protein homolog OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) GN=FGSG_02523 PE=3 SV=1 PF09462 Mus7/MMS22 family GO:0006281//GO:0006974//GO:0031297 DNA repair//cellular response to DNA damage stimulus//replication fork processing -- -- GO:0005634 nucleus KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-17041.0 BP_3 39.48 0.33 6092 642910704 XP_008200524.1 1082 1.4e-114 PREDICTED: nucleolysin TIA-1 isoform p40-like [Tribolium castaneum] 642910703 XM_008202302.1 168 1.12869e-79 PREDICTED: Tribolium castaneum nucleolysin TIA-1 isoform p40-like (LOC657616), mRNA K13201 TIA1, TIAL1 nucleolysin TIA-1/TIAR http://www.genome.jp/dbget-bin/www_bget?ko:K13201 P31483 672 1.9e-68 Nucleolysin TIA-1 isoform p40 OS=Homo sapiens GN=TIA1 PE=1 SV=3 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily) Cluster-17044.0 BP_3 4.00 1.22 449 270006485 EFA02933.1 200 1.9e-13 gustatory receptor 99 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00834//PF08395 Ribulose-phosphate 3 epimerase family//7tm Chemosensory receptor GO:0005975//GO:0050909 carbohydrate metabolic process//sensory perception of taste GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016021 integral component of membrane -- -- Cluster-17051.0 BP_3 3.00 0.37 684 262400963 ACY66384.1 950 3.1e-100 copper/zinc superoxide dismutase [Scylla paramamosain] 262400962 FJ774661.1 644 0 Scylla paramamosain copper/zinc superoxide dismutase mRNA, complete cds K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P08228 379 2.1e-35 Superoxide dismutase [Cu-Zn] OS=Mus musculus GN=Sod1 PE=1 SV=2 PF15234//PF00080 Linker for activation of T-cells//Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801//GO:0007165 oxidation-reduction process//superoxide metabolic process//signal transduction GO:0046872 metal ion binding GO:0016020 membrane KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-1707.0 BP_3 3.00 1.25 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17070.0 BP_3 2.00 0.51 480 821493861 XP_012408640.1 290 7.4e-24 PREDICTED: LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1B [Sarcophilus harrisii] 768311752 CP010980.1 480 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K08794 CAMK1 calcium/calmodulin-dependent protein kinase I http://www.genome.jp/dbget-bin/www_bget?ko:K08794 O14408 535 1.2e-53 Calcium/calmodulin-dependent protein kinase OS=Metarhizium anisopliae PE=2 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-17077.0 BP_3 38.00 1.62 1422 189234280 XP_969457.2 1314 4.0e-142 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 337 3.2e-30 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-17078.0 BP_3 5.00 0.45 832 156364654 XP_001626461.1 139 4.1e-06 predicted protein [Nematostella vectensis]>gi|156213338|gb|EDO34361.1| predicted protein [Nematostella vectensis] 697089100 XM_009659165.1 795 0 Verticillium dahliae VdLs.17 high affinity copper transporter partial mRNA -- -- -- -- O94722 299 4.7e-26 Copper transport protein ctr4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ctr4 PE=1 SV=1 PF04145//PF04879 Ctr copper transporter family//Molybdopterin oxidoreductase Fe4S4 domain GO:0006825//GO:0055114//GO:0035434 copper ion transport//oxidation-reduction process//copper ion transmembrane transport GO:0016491//GO:0005375 oxidoreductase activity//copper ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-17081.0 BP_3 1.00 0.47 392 91088839 XP_970745.1 212 6.6e-15 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] -- -- -- -- -- K13189 RBM14 RNA-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13189 Q94901 180 1.4e-12 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0097159//GO:0043169//GO:0003676//GO:1901363 organic cyclic compound binding//cation binding//nucleic acid binding//heterocyclic compound binding -- -- -- -- Cluster-17084.0 BP_3 1.00 0.40 410 642920073 XP_008192195.1 453 7.9e-43 PREDICTED: ammonium transporter Rh type A [Tribolium castaneum] -- -- -- -- -- K06580 SLC42A, RHAG, RHBG, RHCG ammonium transporter Rh http://www.genome.jp/dbget-bin/www_bget?ko:K06580 Q69D48 316 2.5e-28 Ammonium transporter Rh type B-A OS=Xenopus laevis GN=rhbg-a PE=2 SV=1 PF00909 Ammonium Transporter Family GO:0015696 ammonium transport GO:0008519 ammonium transmembrane transporter activity GO:0016020 membrane KOG3796 Ammonium transporter RHBG Cluster-17087.0 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1709.0 BP_3 38.00 0.94 2241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00747 ssDNA binding protein GO:0006260 DNA replication GO:0003697 single-stranded DNA binding GO:0042025 host cell nucleus -- -- Cluster-17096.0 BP_3 3.00 2.45 345 675759080 XP_008985766.1 198 2.4e-13 PREDICTED: LOW QUALITY PROTEIN: transcription factor jun-D, partial [Callithrix jacchus] 30851192 BC052571.1 345 2.35069e-179 Homo sapiens cDNA clone IMAGE:6455511, **** WARNING: chimeric clone **** -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17099.0 BP_3 4.00 0.61 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17099.1 BP_3 3.00 1.27 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17099.2 BP_3 2.00 0.68 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17104.0 BP_3 3.00 0.41 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17108.0 BP_3 5.00 0.53 743 -- -- -- -- -- 768311757 CP010985.1 731 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- PF17060 Monopolar spindle protein 2 GO:0071988//GO:0030474 protein localization to spindle pole body//spindle pole body duplication -- -- -- -- -- -- Cluster-17110.0 BP_3 4.00 0.44 733 646704078 KDR12433.1 507 7.7e-49 Tetratricopeptide repeat protein 36 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- A8E7I5 469 8.1e-46 Tetratricopeptide repeat protein 36 OS=Danio rerio GN=ttc36 PE=2 SV=1 PF13414//PF13374//PF13181//PF00515//PF13371 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4555 TPR repeat-containing protein Cluster-17111.0 BP_3 1.00 0.69 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17115.0 BP_3 5.00 0.92 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17118.0 BP_3 4.00 0.33 872 -- -- -- -- -- 404312705 AC253545.1 824 0 Prunus persica clone JGIBIXB-13E11, complete sequence -- -- -- -- -- -- -- -- PF02902 Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- -- -- Cluster-17129.0 BP_3 6.00 1.14 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17132.0 BP_3 7.00 0.72 758 755989619 XP_011312243.1 280 1.7e-22 PREDICTED: V-type proton ATPase subunit G [Fopius arisanus] -- -- -- -- -- K02152 ATPeV1G, ATP6G V-type H+-transporting ATPase subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K02152 Q25532 261 1.1e-21 V-type proton ATPase subunit G OS=Manduca sexta PE=3 SV=1 PF00547//PF03938//PF04111//PF17078//PF15003//PF14942 Urease, gamma subunit//Outer membrane protein (OmpH-like)//Autophagy protein Apg6//SWI5-dependent HO expression protein 3//HAUS augmin-like complex subunit 2//Organelle biogenesis, Muted-like protein GO:0051225//GO:0043419//GO:0051028//GO:0031023//GO:0006914//GO:0048309 spindle assembly//urea catabolic process//mRNA transport//microtubule organizing center organization//autophagy//endoplasmic reticulum inheritance GO:0051082//GO:0016151 unfolded protein binding//nickel cation binding GO:0031083//GO:0030133 BLOC-1 complex//transport vesicle KOG1772 Vacuolar H+-ATPase V1 sector, subunit G Cluster-17134.0 BP_3 3.00 0.48 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17137.0 BP_3 4.00 3.85 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17138.1 BP_3 44.00 0.49 4593 189240361 XP_973209.2 4051 0.0e+00 PREDICTED: uncharacterized protein LOC661988 [Tribolium castaneum] 189240360 XM_968116.2 149 3.0982e-69 PREDICTED: Tribolium castaneum uncharacterized LOC661988 (LOC661988), mRNA -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-17140.0 BP_3 7.00 0.37 1212 4506381 NP_002863.1 1009 7.9e-107 ras-related C3 botulinum toxin substrate 2 [Homo sapiens]>gi|386780894|ref|NP_001248306.1| ras-related C3 botulinum toxin substrate 2 [Macaca mulatta]>gi|402884142|ref|XP_003905550.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 [Papio anubis]>gi|426394387|ref|XP_004063479.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 [Gorilla gorilla gorilla]>gi|544462014|ref|XP_005567434.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 [Macaca fascicularis]>gi|635102112|ref|XP_007973887.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 [Chlorocebus sabaeus]>gi|795130625|ref|XP_011834306.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 isoform X2 [Mandrillus leucophaeus]>gi|795332516|ref|XP_011819679.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 [Colobus angolensis palliatus]>gi|795484258|ref|XP_011893541.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 [Cercocebus atys]>gi|795504225|ref|XP_011710761.1| PREDICTED: ras-related C3 botulinum toxin substrate 2 [Macaca nemestrina]>gi|131806|sp|P15153.1|RAC2_HUMAN RecName: Full=Ras-related C3 botulinum toxin substrate 2; AltName: Full=GX; AltName: Full=Small G protein; AltName: Full=p21-Rac2; Flags: Precursor>gi|9955205|pdb|1DS6|A Chain A, Crystal Structure Of A Rac-Rhogdi Complex>gi|20379104|gb|AAM21112.1|AF498965_1 small GTP binding protein RAC2 [Homo sapiens]>gi|190826|gb|AAA36538.1| ras-related C3 botulinum toxin substrate [Homo sapiens]>gi|249583|gb|AAB22207.1| rac1 p21=small GTP-binding protein [human, HL60, Peptide, 192 aa]>gi|16507677|gb|AAH01485.1| Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [Homo sapiens]>gi|30582677|gb|AAP35565.1| ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [Homo sapiens]>gi|47678641|emb|CAG30441.1| RAC2 [Homo sapiens]>gi|61362274|gb|AAX42191.1| ras-related C3 botulinum toxin substrate 2 [synthetic construct]>gi|61362276|gb|AAX42192.1| ras-related C3 botulinum toxin substrate 2 [synthetic construct]>gi|109451450|emb|CAK54586.1| RAC2 [synthetic construct]>gi|109452046|emb|CAK54885.1| RAC2 [synthetic construct]>gi|119580553|gb|EAW60149.1| ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), isoform CRA_a [Homo sapiens]>gi|119580557|gb|EAW60153.1| ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), isoform CRA_a [Homo sapiens]>gi|123993225|gb|ABM84214.1| ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [synthetic construct]>gi|124000221|gb|ABM87619.1| ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [synthetic construct]>gi|157929254|gb|ABW03912.1| ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [synthetic construct]>gi|208965424|dbj|BAG72726.1| ras-related C3 botulinum toxin substrate 2 [synthetic construct]>gi|355563642|gb|EHH20204.1| hypothetical protein EGK_03011 [Macaca mulatta]>gi|355784962|gb|EHH65813.1| hypothetical protein EGM_02656 [Macaca fascicularis]>gi|649120835|gb|AIC55007.1| RAC2, partial [synthetic construct] 520262262 NM_002872.4 1212 0 Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2), mRNA K07860 RAC2 Ras-related C3 botulinum toxin substrate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07860 P15153 1009 3.2e-108 Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens GN=RAC2 PE=1 SV=1 PF03261//PF08477//PF00071//PF00025 Cyclin-dependent kinase 5 activator protein//Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0045859//GO:0010310//GO:0051056//GO:0006184//GO:0030168//GO:0045453//GO:0060263//GO:0007264//GO:0007411//GO:0030031//GO:0008284//GO:0030036 regulation of protein kinase activity//regulation of hydrogen peroxide metabolic process//regulation of small GTPase mediated signal transduction//obsolete GTP catabolic process//platelet activation//bone resorption//regulation of respiratory burst//small GTPase mediated signal transduction//axon guidance//cell projection assembly//positive regulation of cell proliferation//actin cytoskeleton organization GO:0016534//GO:0005525//GO:0003924 cyclin-dependent protein kinase 5 activator activity//GTP binding//GTPase activity GO:0005829//GO:0005886//GO:0016533//GO:0005635 cytosol//plasma membrane//cyclin-dependent protein kinase 5 holoenzyme complex//nuclear envelope KOG0393 Ras-related small GTPase, Rho type Cluster-17141.0 BP_3 10.00 0.42 1430 375273602 AFA43700.1 518 8.0e-50 X-box binding protein 1 [Penaeus monodon] -- -- -- -- -- K09027 XBP1 X box-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09027 Q3SZZ2 256 7.9e-21 X-box-binding protein 1 OS=Bos taurus GN=XBP1 PE=2 SV=1 PF06156//PF03131//PF06005//PF00170//PF07716//PF08172//PF01496 Protein of unknown function (DUF972)//bZIP Maf transcription factor//Protein of unknown function (DUF904)//bZIP transcription factor//Basic region leucine zipper//CASP C terminal//V-type ATPase 116kDa subunit family GO:0006891//GO:0015991//GO:0043093//GO:0000917//GO:0006260//GO:0006355//GO:0015992 intra-Golgi vesicle-mediated transport//ATP hydrolysis coupled proton transport//FtsZ-dependent cytokinesis//barrier septum assembly//DNA replication//regulation of transcription, DNA-templated//proton transport GO:0003677//GO:0015078//GO:0043565//GO:0003700 DNA binding//hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0030173//GO:0033179//GO:0005737 nucleus//transcription factor complex//integral component of Golgi membrane//proton-transporting V-type ATPase, V0 domain//cytoplasm KOG4005 Transcription factor XBP-1 Cluster-17142.0 BP_3 5.00 0.33 1026 307187010 EFN72328.1 206 8.6e-14 Histone-lysine N-methyltransferase SETMAR, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17149.0 BP_3 2.00 0.33 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1716.0 BP_3 3.00 0.56 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17160.1 BP_3 13.69 0.68 1261 -- -- -- -- -- 697082741 XM_009656318.1 654 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17160.2 BP_3 3.31 0.32 788 -- -- -- -- -- 697082741 XM_009656318.1 360 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- PF05399 Ectropic viral integration site 2A protein (EVI2A) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-17160.3 BP_3 14.00 1.34 794 167524252 XP_001746462.1 346 3.9e-30 hypothetical protein [Monosiga brevicollis MX1]>gi|163775224|gb|EDQ88849.1| predicted protein [Monosiga brevicollis MX1] 697073870 XM_009653255.1 584 0 Verticillium dahliae VdLs.17 40S ribosomal protein S24 mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 P0CX32 373 1.2e-34 40S ribosomal protein S24-B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPS24B PE=1 SV=1 PF01282 Ribosomal protein S24e GO:0042254//GO:0019538//GO:0006412 ribosome biogenesis//protein metabolic process//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3424 40S ribosomal protein S24 Cluster-17163.1 BP_3 24.00 0.33 3802 50513239 AAT77811.1 3520 0.0e+00 calpain B [Gecarcinus lateralis] 50513238 AY639153.1 1297 0 Gecarcinus lateralis calpain B (CalpB) mRNA, complete cds K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 2167 5.4e-242 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF04204//PF13202//PF00648//PF13499//PF13833//PF13405//PF00036 Homoserine O-succinyltransferase//EF hand//Calpain family cysteine protease//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand GO:0042967//GO:0019281//GO:0006508//GO:0006555 acyl-carrier-protein biosynthetic process//L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine//proteolysis//methionine metabolic process GO:0008899//GO:0005509//GO:0004198 homoserine O-succinyltransferase activity//calcium ion binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622//GO:0005737 intracellular//cytoplasm KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-17164.1 BP_3 1.00 0.46 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17165.0 BP_3 2.00 0.32 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17172.0 BP_3 3.00 0.38 674 -- -- -- -- -- 697086581 XM_009657908.1 635 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17173.0 BP_3 6.00 1.06 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17174.1 BP_3 2.00 0.86 403 -- -- -- -- -- 761231856 KM881642.1 403 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C444 648 7.8e-67 50S ribosomal protein L22, chloroplastic OS=Oryza sativa GN=rpl22 PE=3 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-17176.0 BP_3 10.00 0.41 1459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17180.0 BP_3 22.00 0.72 1757 642933519 XP_008197452.1 1633 5.0e-179 PREDICTED: protein gooseberry-like isoform X1 [Tribolium castaneum]>gi|270012821|gb|EFA09269.1| gooseberry [Tribolium castaneum] 195586620 XM_002083036.1 74 5.76595e-28 Drosophila simulans GD11918 (Dsim\GD11918), mRNA K09381 PAX3_7 paired box protein 3/7 http://www.genome.jp/dbget-bin/www_bget?ko:K09381 P09082 983 4.9e-105 Protein gooseberry OS=Drosophila melanogaster GN=gsb PE=2 SV=1 PF11504//PF00046//PF00292//PF05920 Colicin Ia//Homeobox domain//'Paired box' domain//Homeobox KN domain GO:0006355//GO:0007275//GO:0019835//GO:0050829 regulation of transcription, DNA-templated//multicellular organismal development//cytolysis//defense response to Gram-negative bacterium GO:0043565//GO:0003700//GO:0003677 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0016021//GO:0005634//GO:0005667 integral component of membrane//nucleus//transcription factor complex KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains Cluster-17188.0 BP_3 1.00 0.39 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17196.1 BP_3 3.00 0.31 761 817208639 XP_012280337.1 817 9.1e-85 PREDICTED: spectrin beta chain, non-erythrocytic 5 isoform X1 [Orussus abietinus] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q13813 461 7.1e-45 Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens GN=SPTAN1 PE=1 SV=3 PF00435//PF05531//PF00621 Spectrin repeat//Nucleopolyhedrovirus P10 protein//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding GO:0019028 viral capsid KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-17197.0 BP_3 7.56 0.35 1320 766931243 XP_011497794.1 215 1.0e-14 PREDICTED: proline-rich protein 4-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17206.0 BP_3 13.00 0.59 1347 -- -- -- -- -- 697068976 XM_009651377.1 1326 0 Verticillium dahliae VdLs.17 cross-pathway control protein mRNA -- -- -- -- P11115 367 1.0e-33 Cross-pathway control protein 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cpc-1 PE=1 SV=2 PF07716//PF00170//PF03131 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-17209.0 BP_3 8.00 2.99 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17211.0 BP_3 12.15 0.53 1402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17212.0 BP_3 2.00 0.37 549 742170779 XP_010885584.1 464 5.6e-44 PREDICTED: dnaJ homolog subfamily C member 2 [Esox lucius] 831494146 XM_012852757.1 36 2.29543e-07 PREDICTED: Fundulus heteroclitus DnaJ (Hsp40) homolog, subfamily C, member 2 (dnajc2), mRNA K09522 DNAJC2 DnaJ homolog subfamily C member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09522 P54103 456 2.0e-44 DnaJ homolog subfamily C member 2 OS=Mus musculus GN=Dnajc2 PE=1 SV=2 PF02841 Guanylate-binding protein, C-terminal domain -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0724 Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains Cluster-17213.0 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17213.1 BP_3 4.00 1.23 448 155966141 ABU41025.1 318 3.9e-27 putative cuticle protein [Lepeophtheirus salmonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-17214.0 BP_3 5.00 0.33 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17216.0 BP_3 5.28 0.52 783 158286603 XP_308831.4 223 7.0e-16 AGAP006931-PA [Anopheles gambiae str. PEST]>gi|157020547|gb|EAA04403.4| AGAP006931-PA [Anopheles gambiae str. PEST] 121484217 EF102012.1 437 0 Portunus pelagicus cuticle protein CB7-like mRNA, complete sequence -- -- -- -- P82119 180 2.8e-12 Cuticle protein 6 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-1722.0 BP_3 1.00 0.37 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17221.0 BP_3 1.05 0.34 440 642934520 XP_001812516.2 328 2.6e-28 PREDICTED: tetraspanin-1-like [Tribolium castaneum] 667677333 AE014297.3 90 1.73922e-37 Drosophila melanogaster chromosome 3R -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-17222.0 BP_3 2.00 0.31 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02480 Alphaherpesvirus glycoprotein E -- -- -- -- GO:0016020 membrane -- -- Cluster-17229.0 BP_3 3.00 0.37 679 780675290 XP_011696249.1 260 3.1e-20 PREDICTED: uncharacterized protein LOC105454956 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-17233.0 BP_3 2.00 0.44 512 -- -- -- -- -- 761231856 KM881642.1 512 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- Q09G52 161 2.9e-10 Photosystem II reaction center protein M OS=Platanus occidentalis GN=psbM PE=3 SV=1 PF05151//PF06596 Photosystem II reaction centre M protein (PsbM)//Photosystem II reaction centre X protein (PsbX) GO:0019684//GO:0015979 photosynthesis, light reaction//photosynthesis -- -- GO:0009523//GO:0016020//GO:0016021 photosystem II//membrane//integral component of membrane -- -- Cluster-17239.0 BP_3 1.00 0.43 402 397746026 AFO63174.1 433 1.6e-40 gamma-interferon-inducible lysosomal thiol reductase [Scylla paramamosain] 397746025 JX094506.1 390 0 Scylla paramamosain gamma-interferon-inducible lysosomal thiol reductase mRNA, complete cds K08059 IFI30, GILT interferon, gamma-inducible protein 30 http://www.genome.jp/dbget-bin/www_bget?ko:K08059 P13284 126 2.6e-06 Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens GN=IFI30 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-1724.0 BP_3 4.00 0.89 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1724.1 BP_3 6.00 0.47 909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17256.0 BP_3 23.62 0.33 3709 91090914 XP_974006.1 2381 1.9e-265 PREDICTED: NCK-interacting protein with SH3 domain [Tribolium castaneum]>gi|270013220|gb|EFA09668.1| hypothetical protein TcasGA2_TC011794 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESJ4 877 2.0e-92 NCK-interacting protein with SH3 domain OS=Mus musculus GN=Nckipsd PE=2 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover Cluster-17263.0 BP_3 8.00 1.13 633 -- -- -- -- -- 768311752 CP010980.1 610 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17265.0 BP_3 12.36 0.31 2197 302139064 ADK94870.1 2218 9.2e-247 saposin isoform 1 [Penaeus monodon] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P07602 360 1.1e-32 Prosaposin OS=Homo sapiens GN=PSAP PE=1 SV=2 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-17267.0 BP_3 15.00 1.74 708 82795521 ABB91674.1 884 1.4e-92 calcified cuticle protein CP19.0 isoform A [Callinectes sapidus] 82795520 DQ288149.1 465 0 Callinectes sapidus calcified cuticle protein CP19.0 isoform A mRNA, complete cds -- -- -- -- P81584 437 4.0e-42 Cuticle protein CP1876 OS=Cancer pagurus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17268.0 BP_3 1.00 0.31 446 694846169 XP_009464099.1 218 1.5e-15 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [Nipponia nippon] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 O95263 203 3.4e-15 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Homo sapiens GN=PDE8B PE=1 SV=2 PF00989//PF08447 PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-17270.0 BP_3 3.00 0.78 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17276.0 BP_3 2.00 0.32 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1728.0 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17281.0 BP_3 2.00 0.32 591 -- -- -- -- -- 768311753 CP010981.1 585 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF04995 Heme exporter protein D (CcmD) GO:0015886//GO:0017004 heme transport//cytochrome complex assembly -- -- GO:0016021 integral component of membrane -- -- Cluster-17281.1 BP_3 1.00 0.32 444 -- -- -- -- -- 768311753 CP010981.1 435 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17282.0 BP_3 1.00 0.35 430 281206819 EFA81003.1 182 2.2e-11 sodium/phosphate symporter [Polysphondylium pallidum PN500] 768311756 CP010984.1 418 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17285.0 BP_3 4.00 1.06 474 312299435 ADQ73633.1 209 1.8e-14 red pigment concentrating hormone precursor [Scylla olivacea] 312299434 HQ428110.1 474 0 Scylla olivacea red pigment concentrating hormone precursor, mRNA, complete cds -- -- -- -- Q23757 188 2.0e-13 Red pigment-concentrating prohormone OS=Callinectes sapidus PE=3 SV=1 PF06377 Adipokinetic hormone GO:0007165 signal transduction GO:0005179 hormone activity -- -- -- -- Cluster-17289.0 BP_3 4.00 0.82 526 321469706 EFX80685.1 142 1.2e-06 hypothetical protein DAPPUDRAFT_303877 [Daphnia pulex] 768311759 CP010987.1 421 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- Q9P602 286 9.6e-25 ATP synthase subunit 5, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=atp-5 PE=3 SV=2 PF00213 ATP synthase delta (OSCP) subunit GO:0015986 ATP synthesis coupled proton transport GO:0046933 proton-transporting ATP synthase activity, rotational mechanism GO:0045259 proton-transporting ATP synthase complex KOG1662 Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 Cluster-17297.0 BP_3 1.00 0.51 385 -- -- -- -- -- 41367337 BX664711.2 385 0 Oryza sativa chromosome 12, . BAC B1001E08 of chromosome 12 of cultivar Nipponbare of ssp. japonica of Oryza sativa (rice), complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-173.0 BP_3 3.00 0.66 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17300.0 BP_3 10.00 0.96 793 -- -- -- -- -- 768311755 CP010983.1 707 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- PF02088 Ornatin GO:0030193//GO:0007155 regulation of blood coagulation//cell adhesion -- -- GO:0005576 extracellular region -- -- Cluster-17305.0 BP_3 3.00 0.36 688 675382869 KFM75766.1 313 2.3e-26 Solute carrier organic anion transporter family member 3A1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q9NYB5 223 2.5e-17 Solute carrier organic anion transporter family member 1C1 OS=Homo sapiens GN=SLCO1C1 PE=2 SV=1 PF07690//PF03137 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-17307.0 BP_3 3.00 0.36 699 -- -- -- -- -- 675324092 CP009080.1 699 0 Verticillium dahliae JR2 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17313.0 BP_3 2.00 0.42 522 291232509 XP_002736198.1 348 1.5e-30 PREDICTED: uncharacterized protein LOC100369871 [Saccoglossus kowalevskii] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17319.0 BP_3 2.00 1.61 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17320.0 BP_3 5.00 0.47 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17322.0 BP_3 8.00 1.18 619 478254834 ENN75070.1 697 6.1e-71 hypothetical protein YQE_08383, partial [Dendroctonus ponderosae] -- -- -- -- -- K19499 ANO4, TMEM16D anoctamin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K19499 Q8C5H1 242 1.4e-19 Anoctamin-4 OS=Mus musculus GN=Ano4 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-17326.0 BP_3 13.00 0.67 1222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17328.0 BP_3 2.00 0.44 513 309242901 BAJ22990.1 443 1.4e-41 cytochrome c [Marsupenaeus japonicus] 260819615 XM_002605086.1 70 2.68471e-26 Branchiostoma floridae hypothetical protein, mRNA K08738 CYC cytochrome c http://www.genome.jp/dbget-bin/www_bget?ko:K08738 P00040 405 1.5e-38 Cytochrome c OS=Schistocerca gregaria PE=1 SV=2 PF00034//PF13442 Cytochrome c//Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0009055//GO:0020037 electron carrier activity//heme binding -- -- KOG3453 Cytochrome c Cluster-17329.0 BP_3 5.00 0.44 844 393395824 AFN08746.1 584 1.0e-57 fatty acid binding protein [Scylla paramamosain] 393395823 JQ824129.1 838 0 Scylla paramamosain fatty acid binding protein mRNA, complete cds K08756 FABP7 fatty acid-binding protein 7, brain http://www.genome.jp/dbget-bin/www_bget?ko:K08756 P0C6G6 253 1.0e-20 Myelin P2 protein OS=Equus caballus GN=PMP2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-17331.0 BP_3 5.00 0.41 878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17332.0 BP_3 9.55 0.50 1216 478253041 ENN73421.1 138 7.9e-06 hypothetical protein YQE_09983, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17336.0 BP_3 1.00 0.59 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17343.0 BP_3 4.00 0.68 576 749798371 XP_011152682.1 208 2.8e-14 PREDICTED: uncharacterized protein LOC105191168 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- P00768 139 1.2e-07 Chymotrypsin-2 OS=Vespa orientalis PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-1735.0 BP_3 2.00 0.57 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17352.0 BP_3 5.00 0.51 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-17358.0 BP_3 1.00 0.44 401 -- -- -- -- -- 768311758 CP010986.1 310 7.93014e-160 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17358.1 BP_3 4.00 0.53 654 568259069 ETN67073.1 149 2.2e-07 initiation factor 5a [Anopheles darlingi] 768311758 CP010986.1 648 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- P87252 632 9.0e-65 Woronin body major protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hex-1 PE=1 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0045901//GO:0045905//GO:0006448//GO:0006452 positive regulation of translational elongation//positive regulation of translational termination//regulation of translational elongation//translational frameshifting GO:0003746//GO:0003723//GO:0043022 translation elongation factor activity//RNA binding//ribosome binding GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-17359.0 BP_3 2.00 0.33 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04706//PF07740//PF13443 Dickkopf N-terminal cysteine-rich region//Ion channel inhibitory toxin//Cro/C1-type HTH DNA-binding domain GO:0006810//GO:0007275//GO:0030178//GO:0009405 transport//multicellular organismal development//negative regulation of Wnt signaling pathway//pathogenesis GO:0008200//GO:0043565 ion channel inhibitor activity//sequence-specific DNA binding GO:0005576 extracellular region -- -- Cluster-17367.0 BP_3 3.00 0.69 500 -- -- -- -- -- 697081646 XM_009655937.1 294 7.89044e-151 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF04627 Mitochondrial ATP synthase epsilon chain GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-17371.0 BP_3 32.56 1.64 1251 189237943 XP_001811459.1 771 3.2e-79 PREDICTED: WD repeat domain-containing protein 83 [Tribolium castaneum] -- -- -- -- -- K13124 MORG1 mitogen-activated protein kinase organizer 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13124 Q5BLX8 552 3.3e-55 WD repeat domain-containing protein 83 OS=Rattus norvegicus GN=Wdr83 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0316 Conserved WD40 repeat-containing protein Cluster-17374.0 BP_3 2.00 0.45 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17375.0 BP_3 5.00 0.91 556 -- -- -- -- -- 14140112 AJ307662.1 517 0 Oryza sativa genomic DNA fragment, chromosome 2 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17376.0 BP_3 1.00 0.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13174 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-17377.1 BP_3 2.00 0.68 433 646719796 KDR21782.1 526 2.9e-51 Round spermatid basic protein 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6PCB5 467 8.1e-46 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-17380.0 BP_3 1.00 0.64 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17396.0 BP_3 4.00 0.35 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17401.0 BP_3 3.00 0.40 653 50513235 AAT77809.1 1041 8.2e-111 calpain alternative form [Gecarcinus lateralis] 195012691 XM_001983691.1 50 4.55188e-15 Drosophila grimshawi GH16049 (Dgri\GH16049), mRNA K08573 CAPN3 calpain-3 http://www.genome.jp/dbget-bin/www_bget?ko:K08573 Q9VT65 673 1.6e-69 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-17405.0 BP_3 1.00 0.95 335 719769482 XP_010218741.1 247 4.9e-19 PREDICTED: LOW QUALITY PROTEIN: KRAB-A domain-containing protein 2, partial [Tinamus guttatus] 90265081 AL442108.2 320 1.79668e-165 Oryza sativa genomic DNA, chromosome 4, BAC clone: H0124E07, complete sequence -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-17409.0 BP_3 2.00 0.33 585 767812875 AJT58471.1 534 4.5e-52 cytochrome oxidase subunit I, partial (mitochondrion) [Anthomyza pleuralis] 768311754 CP010982.1 585 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- A4QUT2 591 4.6e-60 Catalase-peroxidase 2 OS=Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) GN=KATG2 PE=1 SV=1 PF00141 Peroxidase GO:0055114//GO:0006804//GO:0006979 oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress GO:0004601//GO:0020037 peroxidase activity//heme binding -- -- -- -- Cluster-17419.0 BP_3 9.00 1.29 629 167521618 XP_001745147.1 387 5.4e-35 hypothetical protein [Monosiga brevicollis MX1]>gi|163776105|gb|EDQ89725.1| predicted protein [Monosiga brevicollis MX1] 697069092 XM_009651435.1 456 0 Verticillium dahliae VdLs.17 40S ribosomal protein S19 partial mRNA K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 P27073 587 1.4e-59 40S ribosomal protein S19 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=rps19 PE=3 SV=1 PF00424//PF01090 REV protein (anti-repression trans-activator protein)//Ribosomal protein S19e GO:0042254//GO:0006355//GO:0006412 ribosome biogenesis//regulation of transcription, DNA-templated//translation GO:0003700//GO:0003735 transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome GO:0005622//GO:0005840//GO:0005667//GO:0042025 intracellular//ribosome//transcription factor complex//host cell nucleus KOG3411 40S ribosomal protein S19 Cluster-17420.1 BP_3 3.00 0.64 516 -- -- -- -- -- 768311759 CP010987.1 468 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17426.0 BP_3 24.85 1.40 1145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17427.0 BP_3 2.00 0.57 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-17428.0 BP_3 11.00 1.15 754 558168170 XP_006124430.1 591 1.4e-58 PREDICTED: 40S ribosomal protein S23-like, partial [Pelodiscus sinensis] 697066434 XM_009650109.1 691 0 Verticillium dahliae VdLs.17 40S ribosomal protein S23 mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q873W8 677 6.3e-70 40S ribosomal protein S23 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=rps23 PE=2 SV=1 PF00164 Ribosomal protein S12/S23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1749 40S ribosomal protein S23 Cluster-17435.0 BP_3 3.00 0.31 751 749752428 XP_011138561.1 177 1.5e-10 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein CG11148 isoform X3 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17438.0 BP_3 7.00 2.20 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17440.0 BP_3 4.00 0.34 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q01589 143 6.0e-08 Cell wall protein SED1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SED1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17441.0 BP_3 3.00 0.37 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00253 Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-17444.0 BP_3 4.00 1.55 415 195969732 ACG60661.1 480 5.9e-46 hypothetical protein [Macrobrachium rosenbergii] -- -- -- -- -- K02130 ATPeF0F, ATP5J2 F-type H+-transporting ATPase subunit f http://www.genome.jp/dbget-bin/www_bget?ko:K02130 Q9W141 426 4.4e-41 Putative ATP synthase subunit f, mitochondrial OS=Drosophila melanogaster GN=CG4692 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17446.0 BP_3 1.00 5.73 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17450.0 BP_3 1.00 4.57 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17454.1 BP_3 3.00 0.36 696 751218368 XP_011162214.1 738 1.2e-75 PREDICTED: SPARC isoform X2 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- P34714 515 3.6e-51 SPARC OS=Caenorhabditis elegans GN=ost-1 PE=1 SV=1 PF09289//PF07648//PF10591 Follistatin/Osteonectin-like EGF domain//Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG4004 Matricellular protein Osteonectin/SPARC/BM-40 Cluster-17456.0 BP_3 18.00 0.52 1969 646717964 KDR20619.1 1105 9.4e-118 Protein Wnt-10b, partial [Zootermopsis nevadensis] -- -- -- -- -- K01357 WNT10 wingless-type MMTV integration site family, member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K01357 P43446 864 3.4e-91 Protein Wnt-10a OS=Danio rerio GN=wnt10a PE=2 SV=1 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-17457.0 BP_3 2.00 0.54 469 -- -- -- -- -- 299560986 GU183052.1 34 2.51463e-06 Scylla paramamosain microsatellite A428 sequence -- -- -- -- -- -- -- -- PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane -- -- Cluster-17466.0 BP_3 4.90 0.31 1046 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17467.0 BP_3 44.00 0.89 2682 642926467 XP_008191970.1 2783 0.0e+00 PREDICTED: glucose dehydrogenase [FAD, quinone] isoform X1 [Tribolium castaneum] 194767933 XM_001966033.1 172 2.94708e-82 Drosophila ananassae GF19422 (Dana\GF19422), mRNA -- -- -- -- P18172 1144 1.6e-123 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF01266//PF07992//PF05834//PF00732 GMC oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase GO:0055114//GO:0016117 oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016614//GO:0016705 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-17476.0 BP_3 2.00 0.46 501 646699634 KDR10178.1 802 3.3e-83 Ribose-phosphate pyrophosphokinase 2, partial [Zootermopsis nevadensis] 269995930 NM_001076568.2 145 5.32934e-68 Danio rerio phosphoribosyl pyrophosphate synthetase 1B (prps1b), mRNA K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 Q5XGI0 769 9.0e-81 Ribose-phosphate pyrophosphokinase 2 OS=Xenopus tropicalis GN=prps2 PE=2 SV=1 PF14572//PF00156 Phosphoribosyl synthetase-associated domain//Phosphoribosyl transferase domain GO:0006144//GO:0009165//GO:0006098//GO:0009116 purine nucleobase metabolic process//nucleotide biosynthetic process//pentose-phosphate shunt//nucleoside metabolic process GO:0004749//GO:0000287 ribose phosphate diphosphokinase activity//magnesium ion binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-17480.0 BP_3 1.00 0.46 394 761906764 XP_011403028.1 177 7.6e-11 PREDICTED: probable aconitate hydratase, mitochondrial [Amphimedon queenslandica] 697087487 XM_009658361.1 391 0 Verticillium dahliae VdLs.17 aconitate hydratase partial mRNA -- -- -- -- Q4WLN1 229 2.9e-18 Aconitate hydratase, mitochondrial OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=acoA PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-17480.2 BP_3 2.00 0.53 472 56759350 AAW27815.1 254 1.1e-19 SJCHGC06542 protein [Schistosoma japonicum] 768311758 CP010986.1 397 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 C8VG90 324 3.4e-29 Aconitate hydratase, mitochondrial OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=acoA PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-17484.1 BP_3 5.00 0.48 796 762105938 XP_011435546.1 672 6.2e-68 PREDICTED: nucleosome assembly protein 1-like 1 isoform X2 [Crassostrea gigas] -- -- -- -- -- K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 Q7ZY81 638 2.2e-65 Nucleosome assembly protein 1-like 1-B OS=Xenopus laevis GN=nap1l1-b PE=1 SV=1 PF00956 Nucleosome assembly protein (NAP) GO:0006334 nucleosome assembly -- -- GO:0005634 nucleus KOG1507 Nucleosome assembly protein NAP-1 Cluster-17485.0 BP_3 2.00 0.76 418 4507809 NP_003348.1 389 2.1e-35 uteroglobin precursor [Homo sapiens]>gi|112672|sp|P11684.1|UTER_HUMAN RecName: Full=Uteroglobin; AltName: Full=Clara cell phospholipid-binding protein; Short=CCPBP; AltName: Full=Clara cells 10 kDa secretory protein; Short=CC10; AltName: Full=Secretoglobin family 1A member 1; AltName: Full=Urinary protein 1; Short=UP-1; Short=UP1; Short=Urine protein 1; Flags: Precursor>gi|23132|emb|CAA31584.1| unnamed protein product [Homo sapiens]>gi|457933|gb|AAA81885.1| Clara cells 10 kda secretory protein [Homo sapiens]>gi|457935|gb|AAA18297.1| Clara cells 10 kda secretory protein [Homo sapiens]>gi|13325340|gb|AAH04481.1| Secretoglobin, family 1A, member 1 (uteroglobin) [Homo sapiens]>gi|49456517|emb|CAG46579.1| SCGB1A1 [Homo sapiens]>gi|60812644|gb|AAX36221.1| secretoglobin family 1A member 1 [synthetic construct]>gi|60819779|gb|AAX36512.1| secretoglobin family 1A member 1 [synthetic construct]>gi|61354834|gb|AAX41065.1| secretoglobin family 1A member 1 [synthetic construct]>gi|61363169|gb|AAX42347.1| secretoglobin family 1A member 1 [synthetic construct]>gi|119594424|gb|EAW74018.1| secretoglobin, family 1A, member 1 (uteroglobin) [Homo sapiens]>gi|123993399|gb|ABM84301.1| secretoglobin, family 1A, member 1 (uteroglobin) [synthetic construct]>gi|124000519|gb|ABM87768.1| secretoglobin, family 1A, member 1 (uteroglobin) [synthetic construct]>gi|189053293|dbj|BAG35099.1| unnamed protein product [Homo sapiens]>gi|307685191|dbj|BAJ20526.1| secretoglobin, family 1A, member 1 [synthetic construct]>gi|649103981|gb|AIC49942.1| SCGB1A1, partial [synthetic construct] 295821219 NM_003357.4 418 0 Homo sapiens secretoglobin, family 1A, member 1 (uteroglobin) (SCGB1A1), mRNA -- -- -- -- P11684 389 8.7e-37 Uteroglobin OS=Homo sapiens GN=SCGB1A1 PE=1 SV=1 -- -- GO:0043488//GO:0007165//GO:0050727//GO:0032696//GO:0042130//GO:0032713//GO:0032714//GO:0032689//GO:0000122//GO:0007566 regulation of mRNA stability//signal transduction//regulation of inflammatory response//negative regulation of interleukin-13 production//negative regulation of T cell proliferation//negative regulation of interleukin-4 production//negative regulation of interleukin-5 production//negative regulation of interferon-gamma production//negative regulation of transcription from RNA polymerase II promoter//embryo implantation GO:0019834 phospholipase A2 inhibitor activity GO:0005737//GO:0005576 cytoplasm//extracellular region -- -- Cluster-175.0 BP_3 4.00 2.77 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17506.0 BP_3 1.00 0.38 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17507.0 BP_3 6.13 0.41 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04857//PF04690//PF02724//PF02862//PF06459 CAF1 family ribonuclease//YABBY protein//CDC45-like protein//DDHD domain//Ryanodine Receptor TM 4-6 GO:0006874//GO:0006270//GO:0007275//GO:0006816 cellular calcium ion homeostasis//DNA replication initiation//multicellular organismal development//calcium ion transport GO:0046872//GO:0005219 metal ion binding//ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016021//GO:0005634 intracellular//integral component of membrane//nucleus -- -- Cluster-17508.0 BP_3 2.00 0.67 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17521.0 BP_3 3.00 0.35 700 768448419 XP_011566240.1 430 6.3e-40 PREDICTED: zinc finger BED domain-containing protein 1-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- D2EAC2 195 4.6e-14 Zinc finger BED domain-containing protein 6 OS=Mus musculus GN=Zbed6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17525.0 BP_3 4.00 0.33 879 669302019 KFD45721.1 316 1.3e-26 hypothetical protein M513_13399 [Trichuris suis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17526.0 BP_3 2.00 3.23 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17531.0 BP_3 7.00 0.32 1341 675866326 XP_009018723.1 197 1.2e-12 hypothetical protein HELRODRAFT_173891 [Helobdella robusta]>gi|555699797|gb|ESO03030.1| hypothetical protein HELRODRAFT_173891 [Helobdella robusta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02902//PF07378 Ulp1 protease family, C-terminal catalytic domain//Flagellar protein FlbT GO:0006508//GO:0006402//GO:1902209 proteolysis//mRNA catabolic process//negative regulation of bacterial-type flagellum assembly GO:0008234//GO:0048027 cysteine-type peptidase activity//mRNA 5'-UTR binding -- -- -- -- Cluster-17542.0 BP_3 4.00 0.74 551 806629189 AKB96198.1 782 7.5e-81 heat shock protein [Cherax destructor] 224552884 FJ646615.1 158 3.49238e-75 Scylla paramamosain heat shock protein 20.6 isoform 2 mRNA, partial cds -- -- -- -- P30219 154 2.0e-09 Heat shock protein 30D OS=Xenopus laevis GN=hsp30d PE=3 SV=1 PF07352 Bacteriophage Mu Gam like protein GO:0042262 DNA protection GO:0003690 double-stranded DNA binding -- -- KOG3591 Alpha crystallins Cluster-17545.0 BP_3 3.00 0.37 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17547.0 BP_3 2.00 0.32 595 270017007 EFA13453.1 361 5.3e-32 hypothetical protein TcasGA2_TC010684 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-17563.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17567.0 BP_3 3.00 1.46 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17568.0 BP_3 1.00 0.31 448 779990542 XP_011668253.1 286 2.0e-23 PREDICTED: uncharacterized protein LOC105440140 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05868 Rotavirus major outer capsid protein VP7 -- -- -- -- GO:0016021//GO:0019012 integral component of membrane//virion -- -- Cluster-1757.0 BP_3 2.00 0.55 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00157 Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-17574.0 BP_3 1.00 0.39 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17575.0 BP_3 3.00 0.96 442 484759920 YP_007890529.1 200 1.8e-13 NADH dehydrogenase subunit 3 (mitochondrion) [Andalucia godoyi]>gi|462269151|gb|AGH24023.1| NADH dehydrogenase subunit 3 (mitochondrion) [Andalucia godoyi] 597569085 KF990036.1 442 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- Q0ZJ15 480 2.6e-47 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic OS=Vitis vinifera GN=ndhC PE=3 SV=1 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0006814//GO:0006120//GO:0006744//GO:0015992//GO:0055114 sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//proton transport//oxidation-reduction process GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-17576.0 BP_3 16.00 0.43 2071 270017158 EFA13604.1 996 4.3e-105 hypothetical protein TcasGA2_TC010302 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q9GLE4 377 1.1e-34 Matrix metalloproteinase-14 OS=Bos taurus GN=MMP14 PE=2 SV=1 PF07998//PF01400//PF00413//PF10462 Peptidase family M54//Astacin (Peptidase family M12A)//Matrixin//Peptidase M66 GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix -- -- Cluster-17577.2 BP_3 2.00 0.64 442 796536107 AKA60071.1 230 6.1e-17 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (chloroplast) [Picomonas sp. DN1] 597569085 KF990036.1 442 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- P31201 255 3.2e-21 Ribulose bisphosphate carboxylase large chain (Fragment) OS=Salvadora persica GN=rbcL PE=3 SV=2 PF02788 Ribulose bisphosphate carboxylase large chain, N-terminal domain GO:0015977//GO:0046487 carbon fixation//glyoxylate metabolic process GO:0016984 ribulose-bisphosphate carboxylase activity GO:0009573 chloroplast ribulose bisphosphate carboxylase complex -- -- Cluster-17584.1 BP_3 2.00 1.12 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17589.0 BP_3 6.35 0.60 802 -- -- -- -- -- 768311752 CP010980.1 525 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- PF07086//PF04568 Jagunal, ER re-organisation during oogenesis//Mitochondrial ATPase inhibitor, IATP GO:0032780//GO:0007029 negative regulation of ATPase activity//endoplasmic reticulum organization GO:0042030 ATPase inhibitor activity GO:0005739//GO:0005789 mitochondrion//endoplasmic reticulum membrane -- -- Cluster-1759.0 BP_3 3.00 0.32 745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17593.0 BP_3 3.00 0.44 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17594.0 BP_3 7.00 0.84 694 152013725 ABS19978.1 550 7.5e-54 ribosomal protein L18a [Artemia franciscana] 697066146 XM_009649965.1 654 0 Verticillium dahliae VdLs.17 60S ribosomal protein L20 mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 P0CX23 629 2.1e-64 60S ribosomal protein L20-A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL20A PE=1 SV=1 PF01775 Ribosomal L18ae/LX protein domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-176.0 BP_3 2.00 0.48 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17606.0 BP_3 2.00 0.34 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17607.0 BP_3 2.00 0.72 424 321470670 EFX81645.1 352 4.2e-31 hypothetical protein DAPPUDRAFT_211091 [Daphnia pulex] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 276 1.1e-23 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family -- -- GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-17611.0 BP_3 3.00 0.46 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17612.0 BP_3 4.00 0.35 845 -- -- -- -- -- 768311754 CP010982.1 839 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- PF08015 Fungal mating-type pheromone GO:0007165 signal transduction GO:0000772 mating pheromone activity GO:0016020 membrane -- -- Cluster-17614.2 BP_3 9.79 0.59 1088 356984433 AET43964.1 518 6.1e-50 glutathione peroxidase, partial [Reishia clavigera] 488569205 XM_004474165.1 36 4.69784e-07 PREDICTED: Dasypus novemcinctus epididymal secretory glutathione peroxidase-like (LOC101416117), mRNA K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 Q4AEH4 421 4.4e-40 Glutathione peroxidase 3 OS=Macaca fuscata fuscata GN=GPX3 PE=2 SV=2 PF00255 Glutathione peroxidase GO:0006749//GO:0006979//GO:0006804//GO:0055114 glutathione metabolic process//response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004602 glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-17616.1 BP_3 5.00 0.38 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17619.0 BP_3 16.00 1.09 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1763.0 BP_3 5.00 2.48 387 270012070 EFA08518.1 201 1.2e-13 hypothetical protein TcasGA2_TC006171 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17630.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17637.0 BP_3 1.00 0.77 349 -- -- -- -- -- 302406067 XM_003000824.1 216 1.22302e-107 Verticillium albo-atrum VaMs.102 predicted protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17640.0 BP_3 7.00 0.35 1246 665798756 XP_008547267.1 463 1.7e-43 PREDICTED: activator of 90 kDa heat shock protein ATPase homolog 1 [Microplitis demolitor] 697068884 XM_009651331.1 1214 0 Verticillium dahliae VdLs.17 Hsp90 co-chaperone AHA1 mRNA -- -- -- -- Q9P782 674 2.3e-69 Uncharacterized protein C1711.08 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC1711.08 PE=2 SV=1 PF00511//PF09229//PF08327//PF15247 E2 (early) protein, C terminal//Activator of Hsp90 ATPase, N-terminal//Activator of Hsp90 ATPase homolog 1-like protein//Histone RNA hairpin-binding protein RNA-binding domain GO:0006355//GO:0006275//GO:0006950 regulation of transcription, DNA-templated//regulation of DNA replication//response to stress GO:0003700//GO:0051087//GO:0003677//GO:0003723//GO:0001671 transcription factor activity, sequence-specific DNA binding//chaperone binding//DNA binding//RNA binding//ATPase activator activity GO:0005667//GO:0042025 transcription factor complex//host cell nucleus KOG2936 Uncharacterized conserved protein Cluster-17646.0 BP_3 16.51 0.38 2396 751463814 XP_011186824.1 1196 3.2e-128 PREDICTED: uncharacterized protein LOC105214855 [Bactrocera cucurbitae] 642940417 XM_008193059.1 212 1.52812e-104 PREDICTED: Tribolium castaneum poliovirus receptor-related protein 3-like (LOC103312443), partial mRNA -- -- -- -- Q9JLB9 175 3.3e-11 Nectin-3 OS=Mus musculus GN=Pvrl3 PE=1 SV=1 PF08086//PF13895 Ergtoxin family//Immunoglobulin domain GO:0006810//GO:0009405 transport//pathogenesis GO:0019870//GO:0005515 potassium channel inhibitor activity//protein binding GO:0005576 extracellular region -- -- Cluster-17650.0 BP_3 5.00 0.34 1004 762135008 XP_011450742.1 533 1.0e-51 PREDICTED: 40S ribosomal protein S16 [Crassostrea gigas]>gi|405958969|gb|EKC25047.1| 40S ribosomal protein S16 [Crassostrea gigas] 768311755 CP010983.1 775 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 Q875N2 573 9.7e-58 40S ribosomal protein S16 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=RPS16 PE=1 SV=1 PF00380 Ribosomal protein S9/S16 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-17654.0 BP_3 26.00 5.49 520 820153214 KKX17101.1 347 2.0e-30 60S ribosomal protein L14-like [Scleropages formosus] -- -- -- -- -- K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 Q3T0U2 331 5.8e-30 60S ribosomal protein L14 OS=Bos taurus GN=RPL14 PE=2 SV=3 PF01708//PF01929 Geminivirus putative movement protein//Ribosomal protein L14 GO:0042254//GO:0006412//GO:0046740 ribosome biogenesis//translation//transport of virus in host, cell to cell GO:0003735 structural constituent of ribosome GO:0005840//GO:0016021//GO:0005622 ribosome//integral component of membrane//intracellular KOG3421 60S ribosomal protein L14 Cluster-17655.2 BP_3 2.00 0.35 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1766.0 BP_3 6.00 1.30 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17663.0 BP_3 2.00 0.95 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17667.0 BP_3 6.00 0.39 1025 391347875 XP_003748179.1 150 2.7e-07 PREDICTED: histone H1.0-A-like [Metaseiulus occidentalis] 697068619 XM_009651199.1 885 0 Verticillium dahliae VdLs.17 histone H1 partial mRNA -- -- -- -- Q8J0U2 266 3.9e-22 Histone H1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hH1 PE=3 SV=1 PF00538 linker histone H1 and H5 family GO:0006334 nucleosome assembly GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-17669.0 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17678.0 BP_3 3.00 0.50 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17685.0 BP_3 7.00 0.78 724 635071246 XP_008004460.1 349 1.6e-30 PREDICTED: 60S ribosomal protein L35 [Chlorocebus sabaeus] 697067830 XM_009650805.1 716 0 Verticillium dahliae VdLs.17 60S ribosomal protein L35 mRNA K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 Q8L805 493 1.3e-48 60S ribosomal protein L35 OS=Triticum aestivum GN=RPL35 PE=1 SV=1 PF00831 Ribosomal L29 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3436 60S ribosomal protein L35 Cluster-17686.0 BP_3 5.00 0.33 1023 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17689.0 BP_3 4.00 0.76 544 -- -- -- -- -- 697069850 XM_009651814.1 526 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF04508//PF03449 Viral A-type inclusion protein repeat//Transcription elongation factor, N-terminal GO:0032784//GO:0016032 regulation of DNA-templated transcription, elongation//viral process GO:0003677 DNA binding -- -- -- -- Cluster-17702.0 BP_3 11.04 0.31 1981 642925822 XP_008190442.1 400 5.3e-36 PREDICTED: uncharacterized protein LOC103312193 [Tribolium castaneum]>gi|270008612|gb|EFA05060.1| hypothetical protein TcasGA2_TC015155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BXJ7 200 3.4e-14 Protein amnionless OS=Homo sapiens GN=AMN PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-1771.0 BP_3 2.00 0.53 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17713.0 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17716.0 BP_3 12.15 0.66 1180 478257725 ENN77868.1 963 1.6e-101 hypothetical protein YQE_05546, partial [Dendroctonus ponderosae]>gi|546677692|gb|ERL88486.1| hypothetical protein D910_05872 [Dendroctonus ponderosae] 827541354 XM_004923897.2 56 3.88855e-18 PREDICTED: Bombyx mori bone morphogenetic protein receptor type-1B (LOC101741200), transcript variant X2, mRNA K04673 BMPR1A, ALK3 bone morphogenetic protein receptor type-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04673 P36895 914 3.3e-97 Bone morphogenetic protein receptor type-1A OS=Mus musculus GN=Bmpr1a PE=2 SV=1 PF09280//PF07714//PF06293//PF00069 XPC-binding domain//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006289//GO:0043161//GO:0006468//GO:0006281 nucleotide-excision repair//proteasome-mediated ubiquitin-dependent protein catabolic process//protein phosphorylation//DNA repair GO:0016773//GO:0003684//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//damaged DNA binding//protein kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-17721.0 BP_3 8.66 2.16 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17723.0 BP_3 2.00 4.91 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17724.0 BP_3 2.00 0.31 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17730.0 BP_3 3.00 2.63 340 719769482 XP_010218741.1 465 2.6e-44 PREDICTED: LOW QUALITY PROTEIN: KRAB-A domain-containing protein 2, partial [Tinamus guttatus] 58197543 AP008246.1 319 6.569e-165 Oryza sativa Japonica Group genomic DNA, chromosome 1, BAC clone:B1642C07 K01301 NAALAD N-acetylated-alpha-linked acidic dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01301 Q7LHG5 149 4.7e-09 Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-I PE=3 SV=2 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-17730.1 BP_3 1.00 2.59 286 641789187 XP_008176438.1 366 6.7e-33 PREDICTED: uncharacterized protein LOC101939727 [Chrysemys picta bellii] 58652042 AP008245.2 274 5.60846e-140 Oryza sativa Japonica Group genomic DNA, chromosome 9, BAC clone:OSJNBb0013K10 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17730.3 BP_3 6.00 1.33 509 719769482 XP_010218741.1 724 3.7e-74 PREDICTED: LOW QUALITY PROTEIN: KRAB-A domain-containing protein 2, partial [Tinamus guttatus] 20087088 AC097446.3 491 0 Oryza sativa Japonica Group chromosome 10 clone OSJNBa0034B05, complete sequence -- -- -- -- Q9UR07 312 9.0e-28 Transposon Tf2-11 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-11 PE=3 SV=1 PF00665//PF05615 Integrase core domain//Tho complex subunit 7 GO:0015074//GO:0006397 DNA integration//mRNA processing -- -- GO:0000445 THO complex part of transcription export complex -- -- Cluster-17737.0 BP_3 5.00 1.51 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17741.1 BP_3 1.00 0.41 407 12052860 CAB66603.1 160 7.4e-09 hypothetical protein [Homo sapiens]>gi|117646740|emb|CAL37485.1| hypothetical protein [synthetic construct]>gi|306921515|dbj|BAJ17837.1| DNA-damage-inducible transcript 4 [synthetic construct] 56676369 NM_019058.2 407 0 Homo sapiens DNA-damage-inducible transcript 4 (DDIT4), mRNA K08270 DDIT4, REDD1 DNA-damage-inducible transcript 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08270 Q9NX09 160 3.0e-10 DNA damage-inducible transcript 4 protein OS=Homo sapiens GN=DDIT4 PE=1 SV=1 -- -- GO:0048523//GO:0006950//GO:0035556 negative regulation of cellular process//response to stress//intracellular signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-17744.0 BP_3 2.00 0.93 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17756.0 BP_3 2.00 0.47 497 817056165 XP_012268929.1 356 1.7e-31 PREDICTED: ileal sodium/bile acid cotransporter-like [Athalia rosae]>gi|817056167|ref|XP_012268930.1| PREDICTED: ileal sodium/bile acid cotransporter-like [Athalia rosae]>gi|817056169|ref|XP_012268931.1| PREDICTED: ileal sodium/bile acid cotransporter-like [Athalia rosae] -- -- -- -- -- -- -- -- -- Q12908 190 1.2e-13 Ileal sodium/bile acid cotransporter OS=Homo sapiens GN=SLC10A2 PE=1 SV=2 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-17758.0 BP_3 4.00 0.63 598 91085059 XP_966385.1 157 2.4e-08 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270009037|gb|EFA05485.1| hypothetical protein TcasGA2_TC015669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00861 Ribosomal L18p/L5e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-17762.0 BP_3 1.00 0.50 386 383853588 XP_003702304.1 153 4.5e-08 PREDICTED: vascular endothelial growth factor C [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-17768.0 BP_3 12.00 0.45 1587 556755698 XP_005973202.1 726 6.7e-74 PREDICTED: flavohemoprotein A-like [Pantholops hodgsonii] 675324094 CP009082.1 1578 0 Verticillium dahliae JR2 chromosome 7, complete sequence -- -- -- -- Q7TTP2 854 4.0e-90 Flavohemoprotein OS=Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) GN=hmp PE=3 SV=1 PF08030//PF00175//PF00042 Ferric reductase NAD binding domain//Oxidoreductase NAD-binding domain//Globin GO:0055114 oxidation-reduction process GO:0019825//GO:0020037//GO:0016491 oxygen binding//heme binding//oxidoreductase activity -- -- -- -- Cluster-17771.0 BP_3 1.00 0.62 366 -- -- -- -- -- 768311752 CP010980.1 347 1.9395e-180 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17772.0 BP_3 3.00 0.45 614 646714831 KDR18664.1 256 8.2e-20 Myocyte-specific enhancer factor 2 [Zootermopsis nevadensis] -- -- -- -- -- K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 178 3.7e-12 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-17782.0 BP_3 13.00 14.06 327 509391552 AGN29583.1 454 4.8e-43 ribosomal protein L37 [Acartia pacifica] 260821453 XM_002606002.1 50 2.16264e-15 Branchiostoma floridae hypothetical protein, mRNA K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q9VXX8 420 1.7e-40 Probable 60S ribosomal protein L37-A OS=Drosophila melanogaster GN=RpL37a PE=1 SV=1 PF01155//PF01907//PF01641 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Ribosomal protein L37e//SelR domain GO:0055114//GO:0042254//GO:0006464//GO:0006412 oxidation-reduction process//ribosome biogenesis//cellular protein modification process//translation GO:0003735//GO:0033743//GO:0016151 structural constituent of ribosome//peptide-methionine (R)-S-oxide reductase activity//nickel cation binding GO:0005840//GO:0005622 ribosome//intracellular KOG3475 60S ribosomal protein L37 Cluster-17791.0 BP_3 14.00 0.71 1239 642911074 XP_008200564.1 1485 5.1e-162 PREDICTED: cytosolic carboxypeptidase 6 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09LZ8 704 7.7e-73 Cytosolic carboxypeptidase 6 OS=Mus musculus GN=Agbl4 PE=1 SV=1 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0008270//GO:0004181 zinc ion binding//metallocarboxypeptidase activity -- -- KOG3641 Zinc carboxypeptidase Cluster-17802.0 BP_3 2.00 0.71 426 754350770 XP_011270632.1 185 9.7e-12 hypothetical protein, variant [Capsaspora owczarzaki ATCC 30864] 768311753 CP010981.1 420 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- Q03516 263 3.6e-22 Uncharacterized protein RSN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RSN1 PE=1 SV=1 PF02714 Calcium-dependent channel, 7TM region, putative phosphate -- -- -- -- GO:0016020 membrane -- -- Cluster-17803.0 BP_3 5.00 0.31 1076 -- -- -- -- -- 697088402 XM_009658817.1 913 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17808.0 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17809.0 BP_3 5.00 0.77 605 341887117 EGT43052.1 763 1.3e-78 hypothetical protein CAEBREN_26153 [Caenorhabditis brenneri] 768311752 CP010980.1 599 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00507 759 1.6e-79 Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-1782.0 BP_3 11.00 0.52 1321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17823.0 BP_3 106.00 15.56 620 478263113 ENN81506.1 266 5.7e-21 hypothetical protein YQE_02035, partial [Dendroctonus ponderosae]>gi|546675494|gb|ERL86679.1| hypothetical protein D910_04085, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P11734 144 3.3e-08 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-17828.0 BP_3 2.00 0.56 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11770 GRB2-binding adapter (GAPT) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-17837.0 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17843.0 BP_3 1.00 0.34 431 390348946 XP_781036.3 263 8.9e-21 PREDICTED: fibrocystin-L [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q80ZA4 221 2.7e-17 Fibrocystin-L OS=Mus musculus GN=Pkhd1l1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17849.0 BP_3 3.00 0.66 512 662214576 XP_008481126.1 463 6.8e-44 PREDICTED: uncharacterized protein LOC103517854 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08256//PF08416 Aurein-like antibiotic peptide//Phosphotyrosine-binding domain GO:0006952 defense response GO:0005515 protein binding -- -- -- -- Cluster-17851.0 BP_3 4.00 0.56 633 556758514 XP_005974590.1 184 1.9e-11 PREDICTED: probable ketol-acid reductoisomerase, mitochondrial-like [Pantholops hodgsonii] 697072835 XM_009652898.1 621 0 Verticillium dahliae VdLs.17 ketol-acid reductoisomerase mRNA -- -- -- -- P38674 815 5.3e-86 Ketol-acid reductoisomerase, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=ilv-2 PE=3 SV=2 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0019521//GO:0006098//GO:0055114 D-gluconate metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity -- -- -- -- Cluster-17856.0 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17859.0 BP_3 4.00 0.32 902 506968171 AGM32429.1 403 1.1e-36 SCP-like extracellular domain containing protein 1 [Coptotermes formosanus] -- -- -- -- -- -- -- -- -- P35779 370 3.0e-34 Venom allergen 3 OS=Solenopsis richteri PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3017 Defense-related protein containing SCP domain Cluster-17861.0 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17865.0 BP_3 1.00 1.80 301 665789969 XP_008560647.1 299 4.1e-25 PREDICTED: V-type proton ATPase subunit e 2-like [Microplitis demolitor]>gi|607304620|gb|EZA45713.1| ATP synthase subunit H domain-containing protein [Microplitis demolitor] -- -- -- -- -- K02153 ATPeV0E, ATP6H V-type H+-transporting ATPase subunit e http://www.genome.jp/dbget-bin/www_bget?ko:K02153 P81103 209 4.6e-16 V-type proton ATPase subunit e 1 OS=Bos taurus GN=ATP6V0E1 PE=1 SV=3 PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG3500 Vacuolar H+-ATPase V0 sector, subunit M9.7 (M9.2) Cluster-17866.0 BP_3 5.00 0.49 781 198438325 XP_002131998.1 262 2.1e-20 PREDICTED: dnaJ homolog subfamily A member 1-like [Ciona intestinalis] 302421387 XM_003008478.1 643 0 Verticillium albo-atrum VaMs.102 psi1, mRNA K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 P25294 261 1.1e-21 Protein SIS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-17884.0 BP_3 7.00 0.43 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17892.0 BP_3 9.00 21.56 289 -- -- -- -- -- 768311754 CP010982.1 161 3.71806e-77 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17894.0 BP_3 12.00 0.47 1527 642928617 XP_008199980.1 1399 5.9e-152 PREDICTED: coiled-coil domain-containing protein lobo homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IY82 685 1.5e-70 Dynein regulatory complex subunit 7 OS=Homo sapiens GN=DRC7 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-17895.0 BP_3 2.00 0.35 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17901.0 BP_3 6.00 1.77 455 646722304 KDR23317.1 179 5.2e-11 hypothetical protein L798_05278 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17902.0 BP_3 14.00 0.63 1362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17904.0 BP_3 5.00 0.54 736 873234621 CEM01792.1 552 4.7e-54 unnamed protein product [Vitrella brassicaformis CCMP3155] 589113548 XM_006968735.1 319 1.50163e-164 Trichoderma reesei QM6a thiazole biosynthetic enzyme (TRIREDRAFT_68608), partial mRNA -- -- -- -- C7Z8P6 794 1.7e-83 Thiamine thiazole synthase OS=Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) GN=NECHADRAFT_61890 PE=3 SV=1 PF01134//PF12831//PF01494//PF07992//PF05834//PF01266 Glucose inhibited division protein A//FAD dependent oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase GO:0008033//GO:0055114//GO:0016117 tRNA processing//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0071949//GO:0016705 oxidoreductase activity//flavin adenine dinucleotide binding//FAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG2960 Protein involved in thiamine biosynthesis and DNA damage tolerance Cluster-17927.0 BP_3 2.00 0.35 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17930.0 BP_3 5.00 0.33 1018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17930.1 BP_3 3.00 0.46 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17933.0 BP_3 2.00 0.46 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17946.0 BP_3 3.00 0.38 673 646711968 KDR16950.1 534 5.2e-52 Anion exchange protein 2, partial [Zootermopsis nevadensis] -- -- -- -- -- K13855 SLC4A2, AE2 solute carrier family 4 (anion exchanger), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13855 P13808 462 4.8e-45 Anion exchange protein 2 OS=Mus musculus GN=Slc4a2 PE=1 SV=1 PF00955 HCO3- transporter family GO:0006820 anion transport -- -- GO:0016021 integral component of membrane -- -- Cluster-17956.0 BP_3 4.00 0.59 620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17961.1 BP_3 10.00 0.95 799 265141846 ACY74454.1 506 1.1e-48 ribosomal protein L21 [Malo kingi] 697073416 XM_009653094.1 775 0 Verticillium dahliae VdLs.17 60S ribosomal protein L21-B mRNA K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 O42706 545 1.4e-54 60S ribosomal protein L21-B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl2102 PE=2 SV=2 PF09126//PF01157 Restriction endonuclease NaeI//Ribosomal protein L21e GO:0006412//GO:0042254//GO:0006308//GO:0009307 translation//ribosome biogenesis//DNA catabolic process//DNA restriction-modification system GO:0009036//GO:0003735 Type II site-specific deoxyribonuclease activity//structural constituent of ribosome GO:0005622//GO:0005840//GO:0009359 intracellular//ribosome//Type II site-specific deoxyribonuclease complex KOG1732 60S ribosomal protein L21 Cluster-17962.1 BP_3 2.00 2.54 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17965.0 BP_3 13.00 0.57 1391 196000674 XP_002110205.1 1364 6.2e-148 expressed hypothetical protein [Trichoplax adhaerens]>gi|190588329|gb|EDV28371.1| expressed hypothetical protein [Trichoplax adhaerens] 697081702 XM_009655956.1 1323 0 Verticillium dahliae VdLs.17 60S ribosomal protein L3 partial mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 P59671 1792 6.0e-199 60S ribosomal protein L3 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-3 PE=3 SV=1 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0030529 intracellular//ribosome//intracellular ribonucleoprotein complex KOG0746 60S ribosomal protein L3 and related proteins Cluster-17970.0 BP_3 7.00 0.37 1209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17977.0 BP_3 9.84 0.34 1667 768431183 XP_011556856.1 1406 1.0e-152 PREDICTED: carbonic anhydrase-related protein 10 [Plutella xylostella] 642920813 XM_008194349.1 496 0 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC661205), mRNA -- -- -- -- Q5R4U0 676 1.8e-69 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-17979.0 BP_3 28.42 1.34 1315 642917255 XP_008199223.1 935 3.3e-98 PREDICTED: coiled-coil and C2 domain-containing protein 2A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2K1 405 3.8e-38 Coiled-coil and C2 domain-containing protein 2A OS=Homo sapiens GN=CC2D2A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-17980.0 BP_3 2.00 0.37 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17990.0 BP_3 5.00 0.62 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17992.0 BP_3 4.00 0.68 574 262401087 ACY66446.1 645 6.0e-65 profilin [Scylla paramamosain] 262401086 FJ774724.1 568 0 Scylla paramamosain profilin mRNA, partial cds K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 Q68HB4 272 4.4e-23 Profilin OS=Bombyx mori PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1755 Profilin Cluster-17998.0 BP_3 2.00 0.32 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18.0 BP_3 12.00 4.10 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-180.0 BP_3 4.00 2.74 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18004.0 BP_3 26.27 0.69 2124 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18004.1 BP_3 2.00 0.32 590 170033310 XP_001844521.1 438 6.2e-41 echinoid [Culex quinquefasciatus]>gi|167873928|gb|EDS37311.1| echinoid [Culex quinquefasciatus] -- -- -- -- -- K16680 ED echinoid http://www.genome.jp/dbget-bin/www_bget?ko:K16680 -- -- -- -- PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-18009.0 BP_3 27.00 1.16 1412 -- -- -- -- -- 768311752 CP010980.1 1376 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1801.0 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18019.0 BP_3 1.00 0.41 407 826455924 XP_012533207.1 401 8.4e-37 PREDICTED: mastermind-like protein 3 isoform X13 [Monomorium pharaonis] -- -- -- -- -- K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 330 5.9e-30 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2494 C3H1-type Zn-finger protein Cluster-18020.0 BP_3 2.00 0.46 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18033.0 BP_3 24.00 1.53 1046 91081061 XP_975415.1 789 2.2e-81 PREDICTED: 40S ribosomal protein S2 [Tribolium castaneum]>gi|270005317|gb|EFA01765.1| hypothetical protein TcasGA2_TC007364 [Tribolium castaneum] 697088888 XM_009659059.1 1019 0 Verticillium dahliae VdLs.17 40S ribosomal protein S2 mRNA K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 P25443 846 2.2e-89 40S ribosomal protein S2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPS2 PE=1 SV=3 PF00333//PF12235//PF03719 Ribosomal protein S5, N-terminal domain//Fragile X-related 1 protein core C terminal//Ribosomal protein S5, C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840 ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-1804.0 BP_3 2.45 0.57 498 91083853 XP_974019.1 341 9.3e-30 PREDICTED: endocuticle structural glycoprotein ABD-4 [Tribolium castaneum]>gi|270006761|gb|EFA03209.1| hypothetical protein TcasGA2_TC013129 [Tribolium castaneum] 820859608 XM_003697086.2 33 9.64579e-06 PREDICTED: Apis florea larval cuticle protein 8-like (LOC100867255), mRNA -- -- -- -- Q7M4F3 228 4.9e-18 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-18041.0 BP_3 5.47 0.33 1087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18046.0 BP_3 3.00 0.35 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18049.0 BP_3 5.00 0.49 784 -- -- -- -- -- 13241679 AF321227.1 61 4.23346e-21 AF321227 Tribolium castaneum Ftz (ftz), Scr (scr), Dfd (dfd), Zen (zen), and Zen2 (zen2) genes, complete cds; and Pb (pb) gene, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18050.0 BP_3 2.00 0.37 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18051.0 BP_3 2.00 0.32 593 755990759 XP_011312639.1 787 2.1e-81 PREDICTED: microtubule-actin cross-linking factor 1 isoform X2 [Fopius arisanus] -- -- -- -- -- -- -- -- -- Q9UPN3 395 2.5e-37 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens GN=MACF1 PE=1 SV=4 PF00435//PF05384//PF08429 Spectrin repeat//Sensor protein DegS//PLU-1-like protein GO:0007165//GO:0055114 signal transduction//oxidation-reduction process GO:0016301//GO:0016706//GO:0005515 kinase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-18061.0 BP_3 5.00 0.51 768 852799343 XP_012889053.1 266 7.1e-21 PREDICTED: low affinity immunoglobulin epsilon Fc receptor [Dipodomys ordii] -- -- -- -- -- K06563 CD209 CD209 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06563 P20693 233 2.0e-18 Low affinity immunoglobulin epsilon Fc receptor OS=Mus musculus GN=Fcer2 PE=2 SV=1 PF10672 S-adenosylmethionine-dependent methyltransferase -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-18081.0 BP_3 3.00 0.71 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18084.0 BP_3 2.00 0.66 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18086.0 BP_3 15.00 0.48 1789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18089.0 BP_3 2.00 0.40 531 470361589 XP_004365143.1 184 1.6e-11 hypothetical protein CAOG_00272 [Capsaspora owczarzaki ATCC 30864]>gi|765548043|gb|KJE88664.1| hypothetical protein CAOG_000272 [Capsaspora owczarzaki ATCC 30864] 697069970 XM_009651874.1 306 1.7916e-157 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) http://www.genome.jp/dbget-bin/www_bget?ko:K08762 P31824 162 2.3e-10 Acyl-CoA-binding protein homolog OS=Manduca sexta PE=3 SV=1 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-18096.0 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18099.0 BP_3 5.00 0.55 729 685831811 CEF66732.1 412 7.9e-38 Histone H2B family and Histone core domain and Histone-fold domain-containing protein [Strongyloides ratti] 697087519 XM_009658376.1 729 0 Verticillium dahliae VdLs.17 histone H2B mRNA K11252 H2B histone H2B http://www.genome.jp/dbget-bin/www_bget?ko:K11252 Q2HH38 490 2.9e-48 Histone H2B OS=Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) GN=HTB1 PE=3 SV=3 PF03847//PF00125 Transcription initiation factor TFIID subunit A//Core histone H2A/H2B/H3/H4 GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding GO:0005669 transcription factor TFIID complex -- -- Cluster-1810.3 BP_3 6.00 0.31 1218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18100.0 BP_3 2.00 0.40 533 332245592 XP_003271942.1 714 5.6e-73 PREDICTED: 40S ribosomal protein S18 [Nomascus leucogenys] 92444018 BC012322.1 533 0 Homo sapiens mRNA similar to IGF-II mRNA-binding protein 2 (cDNA clone IMAGE:4652395) K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q3T0R1 697 2.1e-72 40S ribosomal protein S18 OS=Bos taurus GN=RPS18 PE=2 SV=3 PF00416 Ribosomal protein S13/S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3311 Ribosomal protein S18 Cluster-18102.0 BP_3 2.00 0.36 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18106.0 BP_3 3.00 0.34 718 646704395 KDR12598.1 498 8.4e-48 rRNA 2'-O-methyltransferase fibrillarin [Zootermopsis nevadensis] 697076660 XM_009654214.1 652 0 Verticillium dahliae VdLs.17 rRNA 2'-O-methyltransferase fibrillarin partial mRNA K14563 NOP1, FBL rRNA 2'-O-methyltransferase fibrillarin http://www.genome.jp/dbget-bin/www_bget?ko:K14563 Q9HE26 521 7.4e-52 rRNA 2'-O-methyltransferase fibrillarin OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=nop-1 PE=3 SV=2 PF01269//PF08704 Fibrillarin//tRNA methyltransferase complex GCD14 subunit GO:0008033//GO:0006364//GO:0009451//GO:0030488 tRNA processing//rRNA processing//RNA modification//tRNA methylation GO:0008168//GO:0016429//GO:0003723 methyltransferase activity//tRNA (adenine-N1-)-methyltransferase activity//RNA binding GO:0031515 tRNA (m1A) methyltransferase complex KOG1596 Fibrillarin and related nucleolar RNA-binding proteins Cluster-18108.0 BP_3 6.93 0.58 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1811.0 BP_3 1.00 0.32 444 565341549 AHC08054.1 329 2.0e-28 micorsomal glutathione S-transferase [Locusta migratoria] 675873955 XM_009024290.1 41 3.04475e-10 Helobdella robusta hypothetical protein partial mRNA K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q3T100 263 3.8e-22 Microsomal glutathione S-transferase 3 OS=Bos taurus GN=MGST3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-18112.0 BP_3 3.00 0.64 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18120.0 BP_3 13.08 0.42 1784 642918409 XP_008191460.1 1328 1.2e-143 PREDICTED: apterous isoform X1 [Tribolium castaneum] 641661021 XM_008183490.1 79 9.73067e-31 PREDICTED: Acyrthosiphon pisum LIM/homeobox protein Lhx2-like (LOC100165973), transcript variant X2, mRNA K09373 LHX2_9 LIM homeobox protein 2/9 http://www.genome.jp/dbget-bin/www_bget?ko:K09373 A2I8Z7 806 1.6e-84 LIM/homeobox protein Lhx9 OS=Astyanax fasciatus GN=lhx9 PE=2 SV=1 PF00046//PF00412//PF05920 Homeobox domain//LIM domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-18124.0 BP_3 4.00 0.67 579 -- -- -- -- -- 768311754 CP010982.1 570 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- P38680 262 6.4e-22 N amino acid transport system protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=mtr PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-18125.0 BP_3 10.00 1.02 763 642913048 XP_008201365.1 418 1.7e-38 PREDICTED: uncharacterized protein LOC103315166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18127.0 BP_3 1.00 0.52 383 642912934 XP_008201313.1 163 3.1e-09 PREDICTED: uncharacterized protein LOC103315149 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14659 Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-18127.1 BP_3 4.00 1.56 414 642912932 XP_008201312.1 176 1.0e-10 PREDICTED: uncharacterized protein LOC103315149 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1813.0 BP_3 2.00 0.42 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18133.0 BP_3 9.00 1.29 627 506965592 AGM32148.1 243 2.7e-18 60S acidic ribosomal protein P2 [Coptotermes formosanus] 697085058 XM_009657148.1 330 9.73672e-171 Verticillium dahliae VdLs.17 60S acidic ribosomal protein P2 partial mRNA K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 Q9C3Z5 295 1.0e-25 60S acidic ribosomal protein P2 OS=Podospora anserina PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-18134.1 BP_3 1.00 0.44 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18137.0 BP_3 5.21 0.59 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18141.0 BP_3 2.00 0.39 536 694539512 XP_009496488.1 158 1.7e-08 Ras-like protein, variant [Fonticula alba]>gi|627946937|gb|KCV68917.1| Ras-like protein, variant [Fonticula alba] 768311753 CP010981.1 526 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- O42785 342 3.1e-31 Ras-like protein OS=Colletotrichum trifolii GN=RAS PE=2 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0395 Ras-related GTPase Cluster-18146.0 BP_3 5.00 0.95 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18147.0 BP_3 8.15 0.33 1488 91086405 XP_966655.1 238 2.4e-17 PREDICTED: retinol dehydrogenase 12 [Tribolium castaneum]>gi|270010298|gb|EFA06746.1| hypothetical protein TcasGA2_TC009680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0055114 oxidation-reduction process GO:0000166//GO:0016491 nucleotide binding//oxidoreductase activity -- -- -- -- Cluster-18149.0 BP_3 1.00 0.57 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1815.0 BP_3 1.00 0.34 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18163.0 BP_3 11.00 0.74 1010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18167.0 BP_3 3.00 0.53 566 -- -- -- -- -- 675324091 CP009079.1 563 0 Verticillium dahliae JR2 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18177.0 BP_3 4.54 0.44 784 642939452 XP_008200399.1 1239 1.1e-133 PREDICTED: cyclic nucleotide-gated cation channel alpha-3-like [Tribolium castaneum] 642939451 XM_008202177.1 455 0 PREDICTED: Tribolium castaneum cyclic nucleotide-gated cation channel alpha-3-like (LOC656479), mRNA K05326 CNGN cyclic nucleotide gated channel, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05326 Q00195 521 8.1e-52 Cyclic nucleotide-gated olfactory channel OS=Rattus norvegicus GN=Cnga2 PE=1 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-1818.0 BP_3 1.00 0.32 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18187.0 BP_3 1.00 0.58 372 321467996 EFX78983.1 324 6.5e-28 hypothetical protein DAPPUDRAFT_2528, partial [Daphnia pulex] -- -- -- -- -- K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 271 3.7e-23 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-1819.0 BP_3 3.00 0.31 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18193.0 BP_3 6.00 0.66 727 269785135 NP_001161523.1 182 3.7e-11 cyclin dependent kinase inhibitor 1C-like protein [Saccoglossus kowalevskii]>gi|585673727|ref|XP_006818464.1| PREDICTED: cyclin dependent kinase inhibitor 1C-like protein isoform X3 [Saccoglossus kowalevskii]>gi|268054027|gb|ACY92500.1| cyclin dependent kinase inhibitor 1C-like protein [Saccoglossus kowalevskii] -- -- -- -- -- K06624 CDKN1B, P27, KIP1 cyclin-dependent kinase inhibitor 1B http://www.genome.jp/dbget-bin/www_bget?ko:K06624 P46527 155 2.1e-09 Cyclin-dependent kinase inhibitor 1B OS=Homo sapiens GN=CDKN1B PE=1 SV=1 PF02234 Cyclin-dependent kinase inhibitor GO:0007050//GO:0045859 cell cycle arrest//regulation of protein kinase activity GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634 nucleus -- -- Cluster-18197.0 BP_3 5.00 0.66 657 294895324 XP_002775135.1 766 6.4e-79 acyl-coa dehydrogenase, putative [Perkinsus marinus ATCC 50983]>gi|239881088|gb|EER06951.1| acyl-coa dehydrogenase, putative, partial [Perkinsus marinus ATCC 50983] 697068645 XM_009651212.1 657 0 Verticillium dahliae VdLs.17 acyl-CoA dehydrogenase mRNA K15980 ACAD9 acyl-CoA dehydrogenase family member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15980 Q2LQP0 290 4.1e-25 Cyclohexane-1-carbonyl-CoA dehydrogenase OS=Syntrophus aciditrophicus (strain SB) GN=SYN_02586 PE=1 SV=1 PF00441//PF02770 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-18198.0 BP_3 5.22 0.80 605 642936074 XP_008198292.1 359 9.2e-32 PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum]>gi|642936076|ref|XP_008198293.1| PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum] -- -- -- -- -- K11124 SMG6, EST1A protein SMG6 http://www.genome.jp/dbget-bin/www_bget?ko:K11124 Q86US8 179 2.8e-12 Telomerase-binding protein EST1A OS=Homo sapiens GN=SMG6 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-18199.0 BP_3 2.00 1.96 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-182.0 BP_3 2.00 0.51 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1820.0 BP_3 2.00 1.33 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18203.0 BP_3 12.00 0.48 1496 146217394 ABQ10739.1 1397 9.9e-152 cathepsin L [Penaeus monodon] 11052 X63568.1 59 1.06645e-19 H.americanus mRNA for cysteine proteinase preproenzyme K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 1188 7.0e-129 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-18208.0 BP_3 2.00 0.38 545 671032215 XP_008706913.1 341 1.0e-29 PREDICTED: LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 D3-like [Ursus maritimus] 767932585 XM_011532227.1 542 0 PREDICTED: Homo sapiens ubiquitin-conjugating enzyme E2D 3 (UBE2D3), transcript variant X6, mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P61078 311 1.3e-27 Ubiquitin-conjugating enzyme E2 D3 OS=Rattus norvegicus GN=Ube2d3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0417 Ubiquitin-protein ligase Cluster-18214.0 BP_3 2.00 0.80 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18225.0 BP_3 3.00 1.15 417 -- -- -- -- -- 114386733 DQ859905.1 67 1.00166e-24 Hyas araneus arasin-2 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18227.0 BP_3 3.00 0.47 601 815922533 XP_012246081.1 642 1.4e-64 PREDICTED: bifunctional DNA-directed RNA polymerase subunit beta'-beta''-like [Bombus impatiens] 589061032 KF765450.1 601 0 Prunus mume isolate BJFU1210120008 plastid, complete genome -- -- -- -- Q4VZP2 1016 2.5e-109 DNA-directed RNA polymerase subunit beta' OS=Cucumis sativus GN=rpoC1 PE=3 SV=3 PF00623//PF04997 RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 1 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG0260 RNA polymerase II, large subunit Cluster-18232.0 BP_3 3.00 0.67 506 -- -- -- -- -- 697076822 XM_009654267.1 500 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF09429 WW domain binding protein 11 GO:0006396 RNA processing -- -- -- -- -- -- Cluster-18235.0 BP_3 2.00 0.32 592 338224450 AEI88103.1 252 2.3e-19 follistatin-like 5 [Scylla paramamosain] 338224449 HM217871.1 182 1.71688e-88 Scylla paramamosain follistatin-like 5 mRNA, partial cds -- -- -- -- Q6MZW2 196 3.0e-14 Follistatin-related protein 4 OS=Homo sapiens GN=FSTL4 PE=2 SV=3 PF09289//PF07648//PF00219//PF00050 Follistatin/Osteonectin-like EGF domain//Kazal-type serine protease inhibitor domain//Insulin-like growth factor binding protein//Kazal-type serine protease inhibitor domain GO:0001558 regulation of cell growth GO:0005515//GO:0005520 protein binding//insulin-like growth factor binding GO:0016942//GO:0005576 insulin-like growth factor binding protein complex//extracellular region -- -- Cluster-18240.0 BP_3 5.00 0.45 826 641648856 XP_008183743.1 384 1.6e-34 PREDICTED: uncharacterized protein LOC103309618 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18249.0 BP_3 3.00 0.56 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1825.0 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18251.1 BP_3 4.00 0.91 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18269.0 BP_3 5.00 0.37 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18279.0 BP_3 2.00 0.94 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18280.0 BP_3 1.00 0.85 342 -- -- -- -- -- 530723034 KC131029.1 136 3.54371e-63 Portunus trituberculatus cardiac muscle actin mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1829.0 BP_3 7.00 0.84 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03824 High-affinity nickel-transport protein GO:0015675//GO:0035444 nickel cation transport//nickel cation transmembrane transport GO:0046872//GO:0015099 metal ion binding//nickel cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-18295.0 BP_3 6.86 0.89 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18301.0 BP_3 2.51 0.52 525 321475910 EFX86871.1 368 7.2e-33 hypothetical protein DAPPUDRAFT_43800 [Daphnia pulex] -- -- -- -- -- K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 O55164 338 8.9e-31 Multiple PDZ domain protein OS=Rattus norvegicus GN=Mpdz PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-18302.0 BP_3 3.00 0.34 718 560138830 CDJ82684.1 678 1.1e-68 Glutamine synthetase domain containing protein [Haemonchus contortus] 697069154 XM_009651466.1 718 0 Verticillium dahliae VdLs.17 glutamine synthetase partial mRNA K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 Q12613 992 1.8e-106 Glutamine synthetase OS=Colletotrichum gloeosporioides GN=GLN1 PE=3 SV=1 PF03951 Glutamine synthetase, beta-Grasp domain GO:0006807//GO:0009252//GO:0006542 nitrogen compound metabolic process//peptidoglycan biosynthetic process//glutamine biosynthetic process GO:0004356 glutamate-ammonia ligase activity -- -- KOG0683 Glutamine synthetase Cluster-18303.1 BP_3 14.14 0.35 2239 831788413 XP_012758738.1 1799 3.6e-198 hypothetical protein SAMD00019534_013170 [Acytostelium subglobosum LB1]>gi|735859370|dbj|GAM18142.1| hypothetical protein SAMD00019534_013170 [Acytostelium subglobosum LB1] 697082841 XM_009656351.1 1773 0 Verticillium dahliae VdLs.17 phosphoenolpyruvate carboxykinase partial mRNA -- -- -- -- Q7RVS9 2632 3.8e-296 Phosphoenolpyruvate carboxykinase [ATP] OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=acu-6 PE=3 SV=2 PF01293 Phosphoenolpyruvate carboxykinase GO:0006094//GO:0006099//GO:0015976 gluconeogenesis//tricarboxylic acid cycle//carbon utilization GO:0004612//GO:0005524 phosphoenolpyruvate carboxykinase (ATP) activity//ATP binding -- -- -- -- Cluster-18309.0 BP_3 2.00 0.32 594 758375337 AJO70009.1 1016 5.9e-108 selenophosphate synthetase [Cherax destructor]>gi|758375878|gb|AJO70191.1| selenophosphate synthetase [Cherax cainii] 328802834 JF508489.1 296 7.3121e-152 Penaeus monodon selenophosphate synthetase mRNA, complete cds K01008 selD, SEPHS selenide, water dikinase http://www.genome.jp/dbget-bin/www_bget?ko:K01008 O18373 916 9.6e-98 Selenide, water dikinase OS=Drosophila melanogaster GN=SelD PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3939 Selenophosphate synthetase Cluster-1831.0 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18310.0 BP_3 2.00 0.34 578 755899222 XP_011295569.1 172 4.3e-10 PREDICTED: uncharacterized protein LOC101895281 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18327.0 BP_3 2.00 0.47 495 694973723 XP_009433296.1 433 2.0e-40 PREDICTED: transcription factor jun-D, partial [Pan troglodytes] 558695422 NM_005354.5 495 0 Homo sapiens jun D proto-oncogene (JUND), transcript variant 1, mRNA >gnl|BL_ORD_ID|16764092 Homo sapiens jun D proto-oncogene (JUND), transcript variant 1, mRNA K04449 JUND transcription factor jun-D http://www.genome.jp/dbget-bin/www_bget?ko:K04449 P17535 433 8.1e-42 Transcription factor jun-D OS=Homo sapiens GN=JUND PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-18328.0 BP_3 7.00 0.51 955 498992346 XP_004532321.1 253 2.9e-19 PREDICTED: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase-like [Ceratitis capitata] 697082165 XM_009656116.1 834 0 Verticillium dahliae VdLs.17 pyrimidine precursor biosynthesis enzyme THI11 partial mRNA -- -- -- -- P42882 1229 7.9e-134 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase OS=Aspergillus parasiticus GN=nmt1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-18329.0 BP_3 8.00 1.16 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18330.0 BP_3 7.00 0.46 1027 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1834.0 BP_3 4.00 0.66 585 270007878 EFA04326.1 267 4.1e-21 hypothetical protein TcasGA2_TC014619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18341.0 BP_3 2.00 0.49 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18342.0 BP_3 15.00 0.33 2476 754342403 XP_004365738.2 2160 5.5e-240 endopeptidase ATP-binding subunit clpB [Capsaspora owczarzaki ATCC 30864]>gi|765548768|gb|KJE89389.1| endopeptidase ATP-binding subunit clpB [Capsaspora owczarzaki ATCC 30864] 768311752 CP010980.1 2440 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- O74402 2377 1.6e-266 Heat shock protein 78, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hsp78 PE=3 SV=1 PF05531//PF07724//PF00448//PF02321//PF01637//PF00005//PF03193//PF05384//PF00910//PF10662//PF00158//PF01695//PF08477//PF07728//PF00004//PF02562//PF10473//PF06414//PF00580//PF00769//PF01025 Nucleopolyhedrovirus P10 protein//AAA domain (Cdc48 subfamily)//SRP54-type protein, GTPase domain//Outer membrane efflux protein//Archaeal ATPase//ABC transporter//Protein of unknown function, DUF258//Sensor protein DegS//RNA helicase//Ethanolamine utilisation - propanediol utilisation//Sigma-54 interaction domain//IstB-like ATP binding protein//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Zeta toxin//UvrD/REP helicase N-terminal domain//Ezrin/radixin/moesin family//GrpE GO:0007165//GO:0006614//GO:0006810//GO:0006355//GO:0006457//GO:0006576//GO:0007264 signal transduction//SRP-dependent cotranslational protein targeting to membrane//transport//regulation of transcription, DNA-templated//protein folding//cellular biogenic amine metabolic process//small GTPase mediated signal transduction GO:0005524//GO:0008134//GO:0003924//GO:0045502//GO:0016887//GO:0000774//GO:0016301//GO:0051087//GO:0008092//GO:0003723//GO:0005215//GO:0042803//GO:0005525//GO:0003724 ATP binding//transcription factor binding//GTPase activity//dynein binding//ATPase activity//adenyl-nucleotide exchange factor activity//kinase activity//chaperone binding//cytoskeletal protein binding//RNA binding//transporter activity//protein homodimerization activity//GTP binding//RNA helicase activity GO:0019028//GO:0019898//GO:0005737//GO:0030286//GO:0005667 viral capsid//extrinsic component of membrane//cytoplasm//dynein complex//transcription factor complex KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases Cluster-18345.0 BP_3 8.00 0.57 965 332376733 AEE63506.1 531 1.7e-51 unknown [Dendroctonus ponderosae]>gi|478250681|gb|ENN71173.1| hypothetical protein YQE_12103, partial [Dendroctonus ponderosae]>gi|546678633|gb|ERL89215.1| hypothetical protein D910_06589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18351.2 BP_3 3.00 0.54 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10099 Anti-sigma-K factor rskA -- -- -- -- GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-18352.0 BP_3 2.00 0.41 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18353.0 BP_3 10.00 0.76 922 56111980 AAV71026.1 1205 1.1e-129 MHC class II antigen [Homo sapiens]>gi|58532281|gb|AAW78743.1| MHC class II antigen [Homo sapiens] 426352688 XM_004043794.1 889 0 PREDICTED: Gorilla gorilla gorilla HLA class II histocompatibility antigen, DP beta 1 chain-like (LOC101141025), mRNA K06752 MHC2 major histocompatibility complex, class II http://www.genome.jp/dbget-bin/www_bget?ko:K06752 P04440 1169 6.9e-127 HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens GN=HLA-DPB1 PE=1 SV=1 PF00969//PF13895 Class II histocompatibility antigen, beta domain//Immunoglobulin domain GO:0019882//GO:0050852//GO:0060333//GO:0019886//GO:0006955//GO:0031295 antigen processing and presentation//T cell receptor signaling pathway//interferon-gamma-mediated signaling pathway//antigen processing and presentation of exogenous peptide antigen via MHC class II//immune response//T cell costimulation GO:0005515 protein binding GO:0000139//GO:0030669//GO:0016020//GO:0010008//GO:0042613//GO:0005765//GO:0032588//GO:0071556//GO:0012507 Golgi membrane//clathrin-coated endocytic vesicle membrane//membrane//endosome membrane//MHC class II protein complex//lysosomal membrane//trans-Golgi network membrane//integral component of lumenal side of endoplasmic reticulum membrane//ER to Golgi transport vesicle membrane -- -- Cluster-18363.0 BP_3 2.00 0.31 605 817056257 XP_012268982.1 679 7.2e-69 PREDICTED: ankyrin repeat domain-containing protein 17 [Athalia rosae] 564245449 XM_006261785.1 48 5.43163e-14 PREDICTED: Alligator mississippiensis ankyrin repeat and KH domain containing 1 (ANKHD1), transcript variant X3, mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 O75179 632 8.4e-65 Ankyrin repeat domain-containing protein 17 OS=Homo sapiens GN=ANKRD17 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-18366.0 BP_3 3.00 0.36 692 262401075 ACY66440.1 827 5.7e-86 putative myosin regulatory light chain 2 smooth muscle [Scylla paramamosain] 262401074 FJ774718.1 628 0 Scylla paramamosain putative myosin regulatory light chain 2 smooth muscle mRNA, complete cds K12755 MYL9 myosin regulatory light chain 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12755 P40423 738 4.9e-77 Myosin regulatory light chain sqh OS=Drosophila melanogaster GN=sqh PE=1 SV=1 PF13499//PF10591//PF13405//PF13833//PF00036//PF15150//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF hand//Phorbol-12-myristate-13-acetate-induced//EF hand GO:0006915//GO:0001836//GO:0006974//GO:0007165//GO:0006919 apoptotic process//release of cytochrome c from mitochondria//cellular response to DNA damage stimulus//signal transduction//activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-18375.1 BP_3 12.20 0.50 1476 642927632 XP_008195342.1 514 2.4e-49 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9BVJ7 315 1.2e-27 Dual specificity protein phosphatase 23 OS=Homo sapiens GN=DUSP23 PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-1838.0 BP_3 4.02 1.21 451 270010676 EFA07124.1 168 9.6e-10 hypothetical protein TcasGA2_TC010115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N6V9 132 5.9e-07 Testis-expressed sequence 9 protein OS=Homo sapiens GN=TEX9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-18380.0 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01562 Reprolysin family propeptide GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-184.0 BP_3 3.00 1.16 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18403.0 BP_3 7.00 0.45 1049 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18405.1 BP_3 2.00 0.35 571 646701982 KDR11449.1 635 8.6e-64 E3 ubiquitin-protein ligase MIB2 [Zootermopsis nevadensis] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q8R516 566 3.6e-57 E3 ubiquitin-protein ligase MIB2 OS=Mus musculus GN=Mib2 PE=1 SV=2 PF06701//PF00569 Mib_herc2//Zinc finger, ZZ type GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding -- -- -- -- Cluster-18409.0 BP_3 8.45 0.37 1399 642937826 XP_008200317.1 862 1.0e-89 PREDICTED: putative methyltransferase NSUN7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09019 EcoRII C terminal GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-18418.0 BP_3 3.00 0.48 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18420.0 BP_3 4.00 0.39 786 646709975 KDR15614.1 736 2.3e-75 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [Zootermopsis nevadensis] -- -- -- -- -- K05629 AIP1 atrophin-1 interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05629 Q9WVQ1 508 2.6e-50 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Mus musculus GN=Magi2 PE=1 SV=2 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0707 Guanylate kinase Cluster-18421.0 BP_3 30.00 0.86 1977 196012373 XP_002116049.1 525 1.7e-50 expressed hypothetical protein [Trichoplax adhaerens]>gi|190581372|gb|EDV21449.1| expressed hypothetical protein [Trichoplax adhaerens] 697074187 XM_009653363.1 1659 0 Verticillium dahliae VdLs.17 high-affinity glucose transporter SNF3 partial mRNA -- -- -- -- Q92253 689 6.7e-71 Probable glucose transporter rco-3 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rco-3 PE=3 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-18422.0 BP_3 3.00 0.39 662 826135715 AKJ26284.1 975 3.8e-103 integrin [Eriocheir sinensis] 826135714 KP795392.1 270 2.32881e-137 Eriocheir sinensis integrin mRNA, complete cds K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 634 5.4e-65 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-18423.0 BP_3 12.00 0.52 1412 66812576 XP_640467.1 1321 6.1e-143 zinc-containing alcohol dehydrogenase [Dictyostelium discoideum AX4]>gi|74997022|sp|Q54TC2.1|ADHX_DICDI RecName: Full=Alcohol dehydrogenase class-3; AltName: Full=Alcohol dehydrogenase class-III; AltName: Full=Glutathione-dependent formaldehyde dehydrogenase; Short=FALDH; Short=FDH; Short=GSH-FDH; AltName: Full=S-(hydroxymethyl)glutathione dehydrogenase>gi|60468488|gb|EAL66492.1| zinc-containing alcohol dehydrogenase [Dictyostelium discoideum AX4] 768311753 CP010981.1 1074 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence K00121 frmA, ADH5, adhC S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00121 P0CL53 1592 9.4e-176 S-(hydroxymethyl)glutathione dehydrogenase OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=FDH1 PE=3 SV=1 PF03721//PF00107//PF00044//PF03435//PF01132 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Zinc-binding dehydrogenase//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Saccharopine dehydrogenase NADP binding domain//Elongation factor P (EF-P) OB domain GO:0006414//GO:0006448//GO:0055114 translational elongation//regulation of translational elongation//oxidation-reduction process GO:0016491//GO:0016616//GO:0051287//GO:0003746//GO:0016620 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//translation elongation factor activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0005840 ribosome KOG0022 Alcohol dehydrogenase, class III Cluster-18426.1 BP_3 1.00 0.32 444 545283768 AGW27404.1 593 5.0e-59 glutamate gated chloride channel exon 3a variant [Bombyx mori] 645015699 XM_008212941.1 68 2.98081e-25 PREDICTED: Nasonia vitripennis glutamate-gated chloride channel (GluCl), transcript variant X5, mRNA K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 585 1.7e-59 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02931 Neurotransmitter-gated ion-channel ligand binding domain GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-18427.0 BP_3 3.00 0.31 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1843.0 BP_3 3.00 0.48 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1843.1 BP_3 3.00 1.53 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18435.0 BP_3 14.00 0.32 2376 91084203 XP_967906.1 1181 1.8e-126 PREDICTED: transmembrane protein 53 [Tribolium castaneum]>gi|270008767|gb|EFA05215.1| hypothetical protein TcasGA2_TC015355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5PPS7 349 2.2e-31 Transmembrane protein 53-A OS=Xenopus laevis GN=tmem53-a PE=2 SV=1 PF02230//PF00326 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2521 Uncharacterized conserved protein Cluster-18444.0 BP_3 8.00 0.38 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18455.0 BP_3 11.00 0.43 1523 125710716 ABN51214.1 1387 1.5e-150 glycosyl-phosphatidylinositol-linked carbonic anhydrase [Callinectes sapidus] 125710715 EF375491.1 1163 0 Callinectes sapidus glycosyl-phosphatidylinositol-linked carbonic anhydrase mRNA, complete cds K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 P43166 456 5.4e-44 Carbonic anhydrase 7 OS=Homo sapiens GN=CA7 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-18459.0 BP_3 7.00 0.32 1331 270015961 EFA12409.1 537 4.7e-52 hypothetical protein TcasGA2_TC016411 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IY51 291 6.4e-25 Tigger transposable element-derived protein 4 OS=Homo sapiens GN=TIGD4 PE=2 SV=2 PF01498//PF03184 Transposase//DDE superfamily endonuclease GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- KOG3105 DNA-binding centromere protein B (CENP-B) Cluster-1846.0 BP_3 4.00 0.93 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18463.0 BP_3 1.00 0.37 420 820972315 XP_012370968.1 359 6.4e-32 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 isoform X2 [Octodon degus] -- -- -- -- -- K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q96K76 355 7.6e-33 Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens GN=USP47 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-18465.0 BP_3 1.00 0.51 385 642935122 XP_008197897.1 419 6.5e-39 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18475.0 BP_3 2.00 1.16 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18478.0 BP_3 29.00 0.88 1880 857979428 CEO94947.1 211 4.2e-14 hypothetical protein PBRA_003760 [Plasmodiophora brassicae] 768311752 CP010980.1 1581 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- Q8J0P4 572 2.4e-57 Probable glycosidase crf1 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=crf1 PE=1 SV=2 PF06784//PF00722 Uncharacterised protein family (UPF0240)//Glycosyl hydrolases family 16 GO:0032981//GO:0005975 mitochondrial respiratory chain complex I assembly//carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-18488.0 BP_3 2.00 0.83 407 546677314 ERL88171.1 392 9.2e-36 hypothetical protein D910_05559 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18489.0 BP_3 2.00 0.69 431 553832073 AGY61442.1 382 1.4e-34 50S ribosomal protein L16 [Lotharella sp. CCMP622] 597569085 KF990036.1 431 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- A0ZZ72 583 2.9e-59 50S ribosomal protein L16, chloroplastic OS=Gossypium barbadense GN=rpl16 PE=3 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3422 Mitochondrial ribosomal protein L16 Cluster-1849.0 BP_3 19.95 1.45 956 546674358 ERL85745.1 653 1.2e-65 hypothetical protein D910_03160 [Dendroctonus ponderosae] -- -- -- -- -- K09622 KLK14 kallikrein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09622 Q00871 542 3.6e-54 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-18491.0 BP_3 10.38 0.42 1485 270004482 EFA00930.1 659 3.7e-66 hypothetical protein TcasGA2_TC003836 [Tribolium castaneum] -- -- -- -- -- K07962 ARL13B, ARL2L1 ADP-ribosylation factor-like protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K07962 Q8JHI3 272 1.1e-22 ADP-ribosylation factor-like protein 13B OS=Danio rerio GN=arl13b PE=1 SV=1 PF00025//PF02421//PF00816//PF00503//PF01926//PF08477 ADP-ribosylation factor family//Ferrous iron transport protein B//H-NS histone family//G-protein alpha subunit//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0006355//GO:0007186//GO:0015684//GO:0007264//GO:0007165 regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway//ferrous iron transport//small GTPase mediated signal transduction//signal transduction GO:0004871//GO:0019001//GO:0005525//GO:0031683//GO:0003677//GO:0015093//GO:0003924 signal transducer activity//guanyl nucleotide binding//GTP binding//G-protein beta/gamma-subunit complex binding//DNA binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0005622//GO:0016021 intracellular//integral component of membrane KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3 Cluster-18493.0 BP_3 10.00 0.72 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18494.0 BP_3 1.00 0.38 419 443708151 ELU03406.1 445 6.8e-42 hypothetical protein CAPTEDRAFT_168454 [Capitella teleta] -- -- -- -- -- K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 Q9C040 393 3.0e-37 Tripartite motif-containing protein 2 OS=Homo sapiens GN=TRIM2 PE=1 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG2177 Predicted E3 ubiquitin ligase Cluster-18496.0 BP_3 2.00 0.78 415 726968576 AIY53011.1 525 3.6e-51 NDUFA13 [Litopenaeus vannamei] -- -- -- -- -- K11353 NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11353 Q95KV7 194 3.5e-14 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Bos taurus GN=NDUFA13 PE=1 SV=3 PF04879 Molybdopterin oxidoreductase Fe4S4 domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3300 NADH:ubiquinone oxidoreductase, B16.6 subunit/cell death-regulatory protein Cluster-18498.0 BP_3 3.00 0.31 764 443684502 ELT88430.1 693 2.2e-70 hypothetical protein CAPTEDRAFT_18698 [Capitella teleta] 797056885 HG313990.1 42 1.50314e-10 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 12 -- -- -- -- Q9R0Q3 661 4.6e-68 Transmembrane emp24 domain-containing protein 2 OS=Mus musculus GN=Tmed2 PE=1 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1692 Putative cargo transport protein EMP24 (p24 protein family) Cluster-185.0 BP_3 4.00 1.43 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04901 Receptor activity modifying family GO:0008277//GO:0006886//GO:0015031 regulation of G-protein coupled receptor protein signaling pathway//intracellular protein transport//protein transport GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-18504.0 BP_3 3.00 1.28 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18505.1 BP_3 2.00 0.86 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18507.0 BP_3 7.00 1.63 498 -- -- -- -- -- 768311752 CP010980.1 204 8.4326e-101 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18511.0 BP_3 8.56 0.79 816 149287004 ABR23401.1 355 3.6e-31 40S ribosomal protein S10 [Ornithodoros parkeri] 697083934 XM_009656731.1 771 0 Verticillium dahliae VdLs.17 40S ribosomal protein S10-A mRNA K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 Q08745 386 3.8e-36 40S ribosomal protein S10-A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPS10A PE=1 SV=1 PF15666 Germinal center-associated lymphoma GO:2000401//GO:0050855 regulation of lymphocyte migration//regulation of B cell receptor signaling pathway -- -- -- -- KOG3344 40s ribosomal protein s10 Cluster-18512.1 BP_3 23.44 2.30 782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18520.0 BP_3 3.00 0.37 682 -- -- -- -- -- 697069578 XM_009651678.1 676 0 Verticillium dahliae VdLs.17 transcriptional activator protein acu-15 partial mRNA -- -- -- -- P87000 869 3.1e-92 Transcriptional activator protein acu-15 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=acu-15 PE=1 SV=2 PF00170//PF06657//PF04082//PF00172 bZIP transcription factor//Centrosome microtubule-binding domain of Cep57//Fungal specific transcription factor domain//Fungal Zn(2)-Cys(6) binuclear cluster domain GO:0006351//GO:0006355 transcription, DNA-templated//regulation of transcription, DNA-templated GO:0003677//GO:0000981//GO:0043565//GO:0008270//GO:0008017//GO:0003700 DNA binding//RNA polymerase II transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding//microtubule binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0045298 nucleus//transcription factor complex//tubulin complex -- -- Cluster-18527.0 BP_3 6.00 0.76 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18529.0 BP_3 10.53 0.36 1721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1853.0 BP_3 4.00 0.69 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18533.0 BP_3 1.00 2.40 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18533.1 BP_3 5.00 0.57 712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01269 Fibrillarin GO:0008033//GO:0006364 tRNA processing//rRNA processing GO:0008168//GO:0003723 methyltransferase activity//RNA binding -- -- -- -- Cluster-18534.0 BP_3 37.00 3.56 792 156408429 XP_001641859.1 950 3.6e-100 predicted protein [Nematostella vectensis]>gi|156228999|gb|EDO49796.1| predicted protein [Nematostella vectensis] 637338280 XM_003225417.2 243 2.87118e-122 PREDICTED: Anolis carolinensis ribosomal protein S3 (rps3), mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 Q3T169 940 2.1e-100 40S ribosomal protein S3 OS=Bos taurus GN=RPS3 PE=2 SV=1 PF07650//PF13096 KH domain//CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P GO:0042254//GO:0034080//GO:0006412 ribosome biogenesis//CENP-A containing nucleosome assembly//translation GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840//GO:0000775//GO:0015935 ribosome//chromosome, centromeric region//small ribosomal subunit KOG3181 40S ribosomal protein S3 Cluster-18536.0 BP_3 1.00 1.32 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18543.0 BP_3 2.00 0.38 543 115653210 XP_788121.2 236 1.5e-17 PREDICTED: endothelial differentiation-related factor 1 [Strongylocentrotus purpuratus] 697073074 XM_009652978.1 450 0 Verticillium dahliae VdLs.17 multiprotein-bridging factor 1 partial mRNA K03627 MBF1 putative transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K03627 Q53IP3 577 1.8e-58 Multiprotein-bridging factor 1 OS=Gibberella fujikuroi GN=MBF1 PE=3 SV=1 PF00610//PF01381//PF12844 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Helix-turn-helix//Helix-turn-helix domain GO:0035556 intracellular signal transduction GO:0043565 sequence-specific DNA binding -- -- KOG3398 Transcription factor MBF1 Cluster-18545.0 BP_3 2.00 0.62 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18547.0 BP_3 3.00 0.49 588 524875599 XP_005094525.1 270 1.9e-21 PREDICTED: fructose-1,6-bisphosphatase 1-like [Aplysia californica] 697068952 XM_009651365.1 582 0 Verticillium dahliae VdLs.17 fructose-1,6-bisphosphatase mRNA K03841 FBP, fbp fructose-1,6-bisphosphatase I http://www.genome.jp/dbget-bin/www_bget?ko:K03841 P09201 328 1.4e-29 Fructose-1,6-bisphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FBP1 PE=1 SV=2 PF00316 Fructose-1-6-bisphosphatase GO:0006098//GO:0006096//GO:0006000//GO:0005975//GO:0006013//GO:0015976//GO:0006094 pentose-phosphate shunt//glycolytic process//fructose metabolic process//carbohydrate metabolic process//mannose metabolic process//carbon utilization//gluconeogenesis GO:0042132//GO:0042578 fructose 1,6-bisphosphate 1-phosphatase activity//phosphoric ester hydrolase activity -- -- KOG1458 Fructose-1,6-bisphosphatase Cluster-18548.0 BP_3 1.00 0.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05432 Bone sialoprotein II (BSP-II) GO:0007155//GO:0001503 cell adhesion//ossification -- -- GO:0005576 extracellular region -- -- Cluster-18550.0 BP_3 1.00 0.76 350 302393716 P46575.2 268 1.9e-21 RecName: Full=Ubiquitin-60S ribosomal protein L40; AltName: Full=Ubiquitin A-52 residue ribosomal protein fusion product 1; Contains: RecName: Full=Ubiquitin; Contains: RecName: Full=60S ribosomal protein L40; AltName: Full=CEP52; AltName: Full=CEP53; Flags: Precursor [Eimeria bovis] 768311753 CP010981.1 248 1.99573e-125 Verticillium dahliae VdLs.17 chromosome 2, complete sequence K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P0CH08 289 2.9e-25 Ubiquitin-60S ribosomal protein L40 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL40A PE=1 SV=1 PF01020 Ribosomal L40e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-18556.0 BP_3 5.00 0.33 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18556.2 BP_3 12.00 0.36 1907 646707345 KDR14151.1 760 9.2e-78 hypothetical protein L798_11789 [Zootermopsis nevadensis] -- -- -- -- -- K08136 SPOCK sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) http://www.genome.jp/dbget-bin/www_bget?ko:K08136 Q92563 348 2.3e-31 Testican-2 OS=Homo sapiens GN=SPOCK2 PE=1 SV=1 PF07648//PF10591//PF13833//PF00036//PF00050//PF13202 Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//Kazal-type serine protease inhibitor domain//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG3555 Ca2+-binding proteoglycan Testican Cluster-18575.0 BP_3 13.00 0.53 1472 641657806 XP_008180482.1 424 6.5e-39 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07652 Flavivirus DEAD domain GO:0019079 viral genome replication GO:0008026//GO:0005524 ATP-dependent helicase activity//ATP binding -- -- -- -- Cluster-18577.2 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18584.0 BP_3 1.00 0.43 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18596.0 BP_3 4.73 0.96 530 -- -- -- -- -- 768311752 CP010980.1 527 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- PF02366 Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0006493 protein O-linked glycosylation GO:0000030 mannosyltransferase activity GO:0000136//GO:0016020 alpha-1,6-mannosyltransferase complex//membrane -- -- Cluster-18596.1 BP_3 3.27 0.35 746 -- -- -- -- -- 768311752 CP010980.1 405 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1860.0 BP_3 5.00 1.34 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1861.0 BP_3 3.00 0.48 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18611.0 BP_3 25.00 0.79 1820 826443606 XP_012530812.1 1420 2.6e-154 PREDICTED: gastrin/cholecystokinin type B receptor-like isoform X1 [Monomorium pharaonis]>gi|826443611|ref|XP_012530813.1| PREDICTED: gastrin/cholecystokinin type B receptor-like isoform X1 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-18612.0 BP_3 3.00 0.31 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00020 TNFR/NGFR cysteine-rich region -- -- GO:0005515 protein binding -- -- -- -- Cluster-18620.0 BP_3 1.00 0.39 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18628.0 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1863.0 BP_3 2.00 0.54 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18631.0 BP_3 1.00 0.37 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18643.0 BP_3 3.00 0.71 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1865.0 BP_3 2.00 0.41 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18651.1 BP_3 7.00 0.48 997 642919667 XP_008192015.1 580 3.6e-57 PREDICTED: otopetrin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTS6 136 4.5e-07 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-18652.0 BP_3 3.00 0.38 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18652.4 BP_3 6.00 0.41 1004 225709858 ACO10775.1 533 1.0e-51 DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Caligus rogercresseyi] 727011722 XM_010397285.1 95 6.8851e-40 PREDICTED: Corvus cornix cornix polymerase (RNA) II (DNA directed) polypeptide H (POLR2H), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 502 1.7e-49 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-18654.0 BP_3 5.00 0.40 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18656.0 BP_3 12.00 0.39 1765 744514379 AJC97112.1 1002 7.4e-106 Rab1A [Macrobrachium rosenbergii] 262401000 FJ774681.1 644 0 Scylla paramamosain Ras-related protein Rab-1A mRNA, partial cds K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q05974 924 3.4e-98 Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1 PF03193//PF00005//PF10662//PF00071//PF04670//PF01926//PF07728//PF08477//PF02421//PF00025//PF00004 Protein of unknown function, DUF258//ABC transporter//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA) GO:0006576//GO:0007264//GO:0015684 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0003924//GO:0015093//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding//ATPase activity GO:0016021 integral component of membrane KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-18663.0 BP_3 10.00 0.40 1507 449678845 XP_004209172.1 422 1.1e-38 PREDICTED: uncharacterized protein LOC101240627 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01899//PF05225//PF03184 Na+/H+ ion antiporter subunit//helix-turn-helix, Psq domain//DDE superfamily endonuclease GO:0006812 cation transport GO:0003677//GO:0003676//GO:0008324 DNA binding//nucleic acid binding//cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-18678.0 BP_3 4.00 0.72 558 -- -- -- -- -- 697067726 XM_009650753.1 558 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1871.0 BP_3 4.00 0.80 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1873.0 BP_3 1.00 0.44 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1880.0 BP_3 5.20 0.57 730 270003224 EEZ99671.1 224 5.0e-16 hypothetical protein TcasGA2_TC002428 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF01777 Ligand-gated ion channel//Ribosomal L27e protein family GO:0042254//GO:0006811//GO:0007268//GO:0006412//GO:0007165 ribosome biogenesis//ion transport//synaptic transmission//translation//signal transduction GO:0003735//GO:0004970 structural constituent of ribosome//ionotropic glutamate receptor activity GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular -- -- Cluster-1885.1 BP_3 28.48 0.87 1865 642934530 XP_008197701.1 1007 2.1e-106 PREDICTED: fibroblast growth factor receptor 4 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 G3V9H8 586 5.6e-59 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Rattus norvegicus GN=Ret PE=1 SV=1 PF00069//PF03785//PF07714 Protein kinase domain//Peptidase family C25, C terminal ig-like domain//Protein tyrosine kinase GO:0006508//GO:0006468 proteolysis//protein phosphorylation GO:0005524//GO:0008233//GO:0004672 ATP binding//peptidase activity//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-1895.0 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-19.0 BP_3 7.00 2.69 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-190.0 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1901.0 BP_3 3.00 0.49 586 449273738 EMC83152.1 198 4.2e-13 hypothetical protein A306_08766, partial [Columba livia] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15324 Hedgehog signalling target GO:0007224 smoothened signaling pathway -- -- -- -- -- -- Cluster-1904.0 BP_3 4.00 0.45 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1910.0 BP_3 3.00 1.26 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1914.0 BP_3 5.00 0.55 731 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1945.0 BP_3 2.00 0.44 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1947.0 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1948.0 BP_3 5.02 0.33 1021 546682026 ERL92022.1 349 2.3e-30 hypothetical protein D910_09344, partial [Dendroctonus ponderosae] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46107 252 1.6e-20 Lipase 1 OS=Drosophila melanogaster GN=Lip1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-1953.0 BP_3 3.00 0.81 470 470298759 XP_004346259.1 452 1.2e-42 NAD-specific glutamate dehydrogenase [Capsaspora owczarzaki ATCC 30864]>gi|765554475|gb|KJE95096.1| NAD-specific glutamate dehydrogenase [Capsaspora owczarzaki ATCC 30864] 768311755 CP010983.1 461 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- P00365 703 3.8e-73 NAD-specific glutamate dehydrogenase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gdh-1 PE=1 SV=4 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GO:0055114//GO:0006520 oxidation-reduction process//cellular amino acid metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-1959.0 BP_3 4.00 0.33 871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1962.0 BP_3 24.00 0.85 1657 478249860 ENN70367.1 494 5.6e-47 hypothetical protein YQE_12874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NQW6 260 3.1e-21 Actin-binding protein anillin OS=Homo sapiens GN=ANLN PE=1 SV=2 PF13000 Acetyl-coenzyme A transporter 1 GO:0015876 acetyl-CoA transport GO:0008521 acetyl-CoA transporter activity GO:0016021 integral component of membrane -- -- Cluster-1964.0 BP_3 1.00 0.61 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-197.2 BP_3 4.00 0.32 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1978.0 BP_3 4.00 0.71 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-198.0 BP_3 7.00 1.38 536 817220308 XP_012285782.1 450 2.3e-42 PREDICTED: uncharacterized protein LOC105702648 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1987.0 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1998.0 BP_3 3.00 1.03 431 -- -- -- -- -- 745399079 NM_152703.3 431 0 Homo sapiens sterile alpha motif domain containing 9-like (SAMD9L), transcript variant 1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2.0 BP_3 7.00 3.72 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-20.0 BP_3 7.00 5.11 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2002.0 BP_3 2.00 1.19 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2008.0 BP_3 2.47 0.78 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2010.0 BP_3 1.00 0.79 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2014.0 BP_3 3.17 0.45 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-2018.0 BP_3 9.00 1.22 647 270017072 EFA13518.1 240 6.2e-18 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 161 3.7e-10 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-202.0 BP_3 7.31 1.30 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-202.1 BP_3 15.69 2.93 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2022.0 BP_3 2.00 0.40 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2029.0 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2031.0 BP_3 6.00 0.55 818 91082947 XP_976416.1 403 9.9e-37 PREDICTED: transcriptional adapter 2-beta [Tribolium castaneum]>gi|270007048|gb|EFA03496.1| hypothetical protein TcasGA2_TC013496 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-204.0 BP_3 7.00 1.39 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2040.0 BP_3 10.03 0.43 1410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2042.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2044.0 BP_3 2.00 0.74 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2054.0 BP_3 3.00 0.82 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00434 Glycoprotein VP7 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-2058.0 BP_3 7.00 0.48 1001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2064.0 BP_3 2.00 0.42 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2079.0 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2088.0 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-209.0 BP_3 2.00 1.03 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-21.0 BP_3 8.00 1.66 524 242015941 XP_002428601.1 289 1.0e-23 Endocuticle structural glycoprotein SgAbd-4, putative [Pediculus humanus corporis]>gi|212513245|gb|EEB15863.1| Endocuticle structural glycoprotein SgAbd-4, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q7M4F3 222 2.5e-17 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-211.0 BP_3 4.00 1.10 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2115.1 BP_3 3.85 0.33 861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2118.0 BP_3 3.00 0.42 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2123.0 BP_3 4.00 1.00 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2123.1 BP_3 3.00 0.39 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2125.0 BP_3 2.49 0.31 673 546677156 ERL88049.1 231 7.1e-17 hypothetical protein D910_05438 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A8C752 130 1.5e-06 Thyroid adenoma-associated protein homolog OS=Chlorocebus aethiops GN=THADA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-2129.0 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-213.0 BP_3 2.00 0.51 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2130.0 BP_3 7.00 0.53 927 641660705 XP_003243557.2 621 5.9e-62 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- O96006 266 3.5e-22 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-2142.0 BP_3 97.00 3.15 1774 189237521 XP_973068.2 1579 9.2e-173 PREDICTED: aromatic-L-amino-acid decarboxylase [Tribolium castaneum]>gi|270006967|gb|EFA03415.1| hypothetical protein TcasGA2_TC013402 [Tribolium castaneum] -- -- -- -- -- K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P48861 1277 4.0e-139 Aromatic-L-amino-acid decarboxylase OS=Manduca sexta GN=Ddc PE=2 SV=1 PF00155//PF00282//PF01212//PF15476//PF05889 Aminotransferase class I and II//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//Histone deacetylase complex subunit SAP25//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GO:0019752//GO:0009058//GO:0006520//GO:0006355 carboxylic acid metabolic process//biosynthetic process//cellular amino acid metabolic process//regulation of transcription, DNA-templated GO:0030170//GO:0016831//GO:0016740//GO:0016829 pyridoxal phosphate binding//carboxy-lyase activity//transferase activity//lyase activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-2145.0 BP_3 6.00 0.57 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-215.0 BP_3 7.00 1.85 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-217.0 BP_3 3.00 0.92 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2173.0 BP_3 4.00 10.62 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2184.0 BP_3 1.45 0.50 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2189.0 BP_3 2.00 0.76 417 546675058 ERL86313.1 268 2.3e-21 hypothetical protein D910_03721 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2192.0 BP_3 10.00 0.77 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-22.0 BP_3 6.00 4.00 360 240848967 NP_001155502.1 438 3.8e-41 adenine nucleotide translocator-like [Acyrthosiphon pisum]>gi|239793510|dbj|BAH72867.1| ACYPI002892 [Acyrthosiphon pisum] 67083834 DQ066215.1 93 3.00342e-39 Ixodes scapularis isolate ISUFL14 ADP/ATP translocase mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q7PQV7 425 5.0e-41 ADP,ATP carrier protein 2 OS=Anopheles gambiae GN=AGAP002358 PE=3 SV=2 PF00018 SH3 domain GO:0006810//GO:0055085 transport//transmembrane transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0005743//GO:0016021 mitochondrial inner membrane//integral component of membrane KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-2208.1 BP_3 18.00 0.43 2318 641660705 XP_003243557.2 626 3.9e-62 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- O96006 282 1.2e-23 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 PF00096//PF02892//PF14372//PF05699 Zinc finger, C2H2 type//BED zinc finger//Domain of unknown function (DUF4413)//hAT family C-terminal dimerisation region -- -- GO:0003677//GO:0046872//GO:0046983 DNA binding//metal ion binding//protein dimerization activity -- -- -- -- Cluster-221.0 BP_3 1.00 0.37 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2216.0 BP_3 1.00 0.34 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2226.0 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2228.0 BP_3 3.00 0.43 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2239.0 BP_3 3.00 0.48 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2244.0 BP_3 3.00 3.96 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-225.0 BP_3 2.00 1.17 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2251.0 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2259.0 BP_3 30.00 1.22 1479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2269.0 BP_3 4.00 1.04 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2274.0 BP_3 5.00 1.60 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2287.0 BP_3 3.00 0.54 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2293.0 BP_3 6.36 1.15 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854 P-11 zinc finger -- -- GO:0003723//GO:0008270 RNA binding//zinc ion binding -- -- -- -- Cluster-23.0 BP_3 7.00 1.44 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-230.0 BP_3 2.00 0.49 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2300.0 BP_3 2.00 0.44 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2334.0 BP_3 7.60 27.30 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2339.0 BP_3 7.55 0.48 1044 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-234.0 BP_3 1.00 0.47 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2342.0 BP_3 5.00 0.49 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2356.0 BP_3 6.21 1.52 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-236.0 BP_3 1.00 1.93 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2366.0 BP_3 4.00 1.74 401 -- -- -- -- -- 768311753 CP010981.1 401 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-237.0 BP_3 6.12 6.40 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-238.0 BP_3 1.00 3.03 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2380.0 BP_3 3.00 0.78 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2381.0 BP_3 5.00 0.35 978 482660336 AGK25052.1 500 6.7e-48 transposase [Chilo suppressalis] -- -- -- -- -- -- -- -- -- Q8N328 391 1.2e-36 PiggyBac transposable element-derived protein 3 OS=Homo sapiens GN=PGBD3 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-2390.0 BP_3 11.00 0.53 1288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2397.0 BP_3 6.00 0.39 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-24.0 BP_3 5.00 5.32 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02513 Spin/Ssty Family GO:0007276 gamete generation -- -- -- -- -- -- Cluster-2401.0 BP_3 6.32 0.61 787 642925736 XP_008201526.1 828 5.0e-86 PREDICTED: group 3 secretory phospholipase A2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P80003 265 3.9e-22 Acidic phospholipase A2 PA4 OS=Heloderma suspectum PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-2413.0 BP_3 2.00 0.41 525 514701549 XP_004998342.1 413 4.4e-38 cytochrome b2 [Salpingoeca rosetta]>gi|326430597|gb|EGD76167.1| cytochrome b2 [Salpingoeca rosetta] 768311756 CP010984.1 522 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence K11517 HAO (S)-2-hydroxy-acid oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K11517 P09437 503 6.6e-50 Cytochrome b2, mitochondrial OS=Hansenula anomala GN=CYB2 PE=1 SV=2 PF01070 FMN-dependent dehydrogenase -- -- GO:0016491 oxidoreductase activity -- -- KOG0538 Glycolate oxidase Cluster-2415.0 BP_3 1.00 0.32 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13545 Crp-like helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-2416.1 BP_3 1.00 1.93 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2420.0 BP_3 4.00 1.06 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2423.0 BP_3 2.00 0.69 431 194375287 BAG62756.1 784 3.4e-81 unnamed protein product [Homo sapiens] 194375286 AK301167.1 431 0 Homo sapiens cDNA FLJ61427 complete cds, highly similar to B-lymphocyte antigen CD19 precursor K06465 CD19 CD19 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06465 P15391 781 3.1e-82 B-lymphocyte antigen CD19 OS=Homo sapiens GN=CD19 PE=1 SV=6 PF00014//PF13895 Kunitz/Bovine pancreatic trypsin inhibitor domain//Immunoglobulin domain -- -- GO:0005515//GO:0004867 protein binding//serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-2428.0 BP_3 3.00 0.36 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2437.0 BP_3 2.00 0.35 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-244.0 BP_3 2.00 0.52 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2449.0 BP_3 4.00 0.40 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08998 Bacterial epsilon antitoxin GO:0006955//GO:0009636//GO:0031342 immune response//response to toxic substance//negative regulation of cell killing GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-2471.0 BP_3 4.00 1.87 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-249.0 BP_3 2.00 0.62 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2494.0 BP_3 3.00 0.42 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-25.0 BP_3 9.00 4.06 397 443693537 ELT94885.1 145 4.0e-07 hypothetical protein CAPTEDRAFT_19592 [Capitella teleta] -- -- -- -- -- -- -- -- -- P00765 142 3.6e-08 Trypsin-1 OS=Astacus astacus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-251.0 BP_3 3.00 0.42 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2518.0 BP_3 2.00 0.46 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2520.0 BP_3 7.00 1.00 629 662219149 XP_008483641.1 239 7.9e-18 PREDICTED: myb-like protein P [Diaphorina citri]>gi|662220839|ref|XP_008484576.1| PREDICTED: myb-like protein P [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2529.1 BP_3 1.00 2.80 283 -- -- -- -- -- 313184264 FN823234.1 120 2.24797e-54 Malus x domestica genomic sequence for BAC clone MC-12 containing a Mal d 1 gene cluster -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2532.0 BP_3 2.00 0.35 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2541.0 BP_3 4.00 1.62 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2546.0 BP_3 2.00 0.45 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2548.0 BP_3 5.00 0.80 594 270000994 EEZ97441.1 441 2.8e-41 hypothetical protein TcasGA2_TC011272 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 214 2.4e-16 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-2562.0 BP_3 3.00 1.22 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2566.0 BP_3 1.00 0.92 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2583.0 BP_3 3.00 0.38 673 158261891 BAF83123.1 688 7.3e-70 unnamed protein product [Homo sapiens] 325003971 HQ842635.1 471 0 Homo sapiens clone 34 tripartite motif-containing 22 (TRIM22) mRNA, complete cds K11999 TRIM6_22_34 tripartite motif-containing protein 6/22/34 http://www.genome.jp/dbget-bin/www_bget?ko:K11999 Q8IYM9 682 1.5e-70 E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens GN=TRIM22 PE=1 SV=1 PF08926 Domain of unknown function (DUF1908) GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0000287//GO:0004674 ATP binding//magnesium ion binding//protein serine/threonine kinase activity -- -- -- -- Cluster-259.0 BP_3 2.00 1.04 382 270003931 EFA00379.1 137 3.2e-06 hypothetical protein TcasGA2_TC003225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2590.0 BP_3 3.00 0.37 683 795179929 XP_011800557.1 930 6.4e-98 PREDICTED: T-complex protein 1 subunit eta isoform X2 [Colobus angolensis palliatus] 767913657 XM_011532479.1 683 0 PREDICTED: Homo sapiens chaperonin containing TCP1, subunit 7 (eta) (CCT7), transcript variant X2, mRNA K09499 CCT7 T-complex protein 1 subunit eta http://www.genome.jp/dbget-bin/www_bget?ko:K09499 Q5R5C8 930 2.6e-99 T-complex protein 1 subunit eta OS=Pongo abelii GN=CCT7 PE=2 SV=1 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0361 Chaperonin complex component, TCP-1 eta subunit (CCT7) Cluster-26.0 BP_3 57.76 4.25 947 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-26.1 BP_3 12.24 1.13 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2600.0 BP_3 8.00 0.54 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2604.0 BP_3 8.00 0.40 1248 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2608.0 BP_3 5.00 0.48 790 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01209 ubiE/COQ5 methyltransferase family -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-2609.0 BP_3 6.00 0.52 852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2609.1 BP_3 13.00 0.54 1454 641681922 XP_008189644.1 146 1.1e-06 PREDICTED: uncharacterized protein LOC100569743 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2611.0 BP_3 5.00 0.87 568 16903179 AAK61417.1 358 1.1e-31 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2619.0 BP_3 5.00 0.67 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2621.1 BP_3 3.00 0.39 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2622.0 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2627.0 BP_3 3.00 2.55 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2631.0 BP_3 7.00 0.64 821 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-264.0 BP_3 6.15 0.63 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2642.0 BP_3 2.00 0.41 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-265.0 BP_3 4.00 0.51 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2653.0 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2665.0 BP_3 2.00 0.48 491 -- -- -- -- -- 768311755 CP010983.1 468 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- PF04557//PF04277 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//Oxaloacetate decarboxylase, gamma chain GO:0006425//GO:0006814//GO:0071436//GO:0006090//GO:0006560//GO:0006525 glutaminyl-tRNA aminoacylation//sodium ion transport//sodium ion export//pyruvate metabolic process//proline metabolic process//arginine metabolic process GO:0015081//GO:0000166//GO:0004819//GO:0008948//GO:0005524 sodium ion transmembrane transporter activity//nucleotide binding//glutamine-tRNA ligase activity//oxaloacetate decarboxylase activity//ATP binding GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-2674.0 BP_3 3.00 0.73 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2679.1 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2691.0 BP_3 5.00 0.44 838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2693.0 BP_3 2.00 0.83 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-27.0 BP_3 9.00 2.31 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2700.0 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2707.0 BP_3 1.00 0.66 361 17512144 AAH19059.1 377 4.5e-34 SP110 nuclear body protein [Homo sapiens]>gi|325464515|gb|ADZ16028.1| SP110 nuclear body protein [synthetic construct] 10439361 AK026488.1 358 0 Homo sapiens cDNA: FLJ22835 fis, clone KAIA4346, highly similar to HUMNUCPHOY Homo sapiens nuclear phosphoprotein mRNA -- -- -- -- Q9HB58 369 1.6e-34 Sp110 nuclear body protein OS=Homo sapiens GN=SP110 PE=1 SV=5 -- -- GO:0007165 signal transduction GO:0004871//GO:0005488 signal transducer activity//binding GO:0005730 nucleolus -- -- Cluster-271.0 BP_3 2.00 0.37 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2715.0 BP_3 2.00 0.58 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2718.0 BP_3 4.00 0.42 753 607352346 EZA47325.1 146 5.8e-07 hypothetical protein X777_16415, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-272.0 BP_3 5.00 0.77 605 675366016 KFM58918.1 189 4.8e-12 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2729.0 BP_3 3.00 0.37 687 795018486 XP_011859227.1 340 1.7e-29 PREDICTED: uncharacterized protein LOC105556736 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04218//PF05225//PF01527 CENP-B N-terminal DNA-binding domain//helix-turn-helix, Psq domain//Transposase GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-273.0 BP_3 3.00 1.61 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2741.0 BP_3 3.00 0.58 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2742.0 BP_3 6.00 0.68 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2742.1 BP_3 4.00 0.36 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-275.0 BP_3 2.00 0.32 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-276.0 BP_3 5.00 0.50 770 815771002 XP_012235659.1 167 2.2e-09 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105679912 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2769.0 BP_3 2.00 0.86 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-278.0 BP_3 1.00 0.34 431 19570323 BAB86288.1 134 8.1e-06 mariner transposase [Apis cerana] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-279.0 BP_3 4.00 1.67 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-28.0 BP_3 16.00 1.73 737 148298826 NP_001091813.1 620 6.1e-62 myosin regulatory light chain 2 [Bombyx mori]>gi|122119463|sp|Q1HPS0.1|MLR_BOMMO RecName: Full=Myosin regulatory light chain 2; Short=MLC-2>gi|95102960|gb|ABF51421.1| myosin light chain 2 [Bombyx mori]>gi|163963296|gb|ABY50568.1| myosin light chain 2 [Bombyx mandarina]>gi|194371731|gb|ACF59735.1| myosin light chain 2 [Bombyx mori]>gi|206114239|gb|ACI05250.1| myosin light chain 2 protein [Bombyx mandarina] -- -- -- -- -- K12754 MYL7 myosin regulatory light chain 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12754 Q1HPS0 620 2.5e-63 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF13405//PF13833//PF00036//PF13499//PF13202 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding GO:0016459 myosin complex KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-281.0 BP_3 2.00 0.82 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2811.0 BP_3 2.00 0.41 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2812.0 BP_3 6.00 0.67 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-282.0 BP_3 4.00 0.55 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2821.0 BP_3 3.00 0.42 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2833.0 BP_3 10.00 0.44 1394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2833.1 BP_3 12.00 0.64 1192 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2835.0 BP_3 6.00 0.53 839 642932150 XP_008196876.1 514 1.4e-49 PREDICTED: uncharacterized protein LOC103313983 [Tribolium castaneum]>gi|642932152|ref|XP_008196877.1| PREDICTED: uncharacterized protein LOC103313983 [Tribolium castaneum]>gi|270012312|gb|EFA08760.1| hypothetical protein TcasGA2_TC006439 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13000 Acetyl-coenzyme A transporter 1 GO:0015876 acetyl-CoA transport GO:0008521 acetyl-CoA transporter activity GO:0016021 integral component of membrane -- -- Cluster-2842.0 BP_3 6.00 0.52 851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2862.0 BP_3 5.00 0.59 698 478257051 ENN77215.1 345 4.5e-30 hypothetical protein YQE_06352, partial [Dendroctonus ponderosae] -- -- -- -- -- K14258 TRET1 facilitated trehalose transporter http://www.genome.jp/dbget-bin/www_bget?ko:K14258 A5LGM7 269 1.2e-22 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF06480//PF00083 FtsH Extracellular//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0008270//GO:0005524//GO:0004222//GO:0022857 zinc ion binding//ATP binding//metalloendopeptidase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-2867.0 BP_3 5.00 0.68 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2869.0 BP_3 3.27 0.34 756 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09226 Restriction endonuclease HincII GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-2874.0 BP_3 4.00 2.24 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2878.0 BP_3 4.00 1.17 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2890.0 BP_3 2.00 0.39 538 -- -- -- -- -- 194381033 AK302920.1 538 0 Homo sapiens cDNA FLJ52032 complete cds, highly similar to Transmembrane emp24 domain-containing protein 10 precursor -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2898.0 BP_3 2.00 0.34 573 826338663 XP_012515650.1 1046 1.9e-111 PREDICTED: serine/threonine-protein phosphatase 4 catalytic subunit isoform X2 [Propithecus coquereli] 746816150 NM_001303507.1 573 0 Homo sapiens protein phosphatase 4, catalytic subunit (PPP4C), transcript variant 5, mRNA K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 P60510 1046 7.8e-113 Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens GN=PPP4C PE=1 SV=1 PF01687//PF00149 Riboflavin kinase//Calcineurin-like phosphoesterase GO:0009231 riboflavin biosynthetic process GO:0016787//GO:0008531 hydrolase activity//riboflavin kinase activity -- -- KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-29.0 BP_3 16.00 1.65 759 171473642 YP_001798474.1 725 4.2e-74 NADH dehydrogenase subunit 5 (mitochondrion) [Cryptopygus antarcticus]>gi|154100264|gb|ABS57572.1| NADH dehydrogenase subunit 5 (mitochondrion) [Cryptopygus antarcticus] 82799085 DQ181369.1 49 1.9175e-14 Plateros sp. UPOL 000303 NADH dehydrogenase subunit 5 gene, partial cds; and tRNA-Phe, tRNA-Glu, and tRNA-Ser genes, complete sequence; mitochondrial K03883 ND5 NADH-ubiquinone oxidoreductase chain 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03883 P07706 434 9.6e-42 NADH-ubiquinone oxidoreductase chain 5 OS=Drosophila yakuba GN=mt:ND5 PE=3 SV=1 PF06455 NADH dehydrogenase subunit 5 C-terminus GO:0006120//GO:0042773//GO:0006744//GO:0022900//GO:0006814//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled electron transport//ubiquinone biosynthetic process//electron transport chain//sodium ion transport//proton transport//oxidation-reduction process GO:0016491//GO:0008137 oxidoreductase activity//NADH dehydrogenase (ubiquinone) activity GO:0044425//GO:0005739 membrane part//mitochondrion KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-2902.0 BP_3 3.00 0.31 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2902.1 BP_3 3.00 0.51 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00104 Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway -- -- -- -- -- -- Cluster-2908.0 BP_3 5.00 0.61 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2913.0 BP_3 1.00 0.99 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2918.0 BP_3 2.00 0.35 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-292.0 BP_3 2.00 0.40 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2920.0 BP_3 12.00 1.02 857 642912531 XP_008200901.1 456 7.4e-43 PREDICTED: uncharacterized protein LOC103315035 [Tribolium castaneum]>gi|270002594|gb|EEZ99041.1| hypothetical protein TcasGA2_TC004915 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00836 Stathmin family GO:0031110 regulation of microtubule polymerization or depolymerization -- -- -- -- -- -- Cluster-2924.0 BP_3 2.00 0.44 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07829 Alpha-A conotoxin PIVA-like protein GO:0007165//GO:0009405//GO:0007268 signal transduction//pathogenesis//synaptic transmission GO:0030550 acetylcholine receptor inhibitor activity GO:0005576 extracellular region -- -- Cluster-2940.0 BP_3 7.00 0.42 1095 861613846 KMQ85754.1 730 1.6e-74 hypothetical protein RF55_15512 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2947.1 BP_3 5.00 0.94 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-2948.0 BP_3 3.00 0.39 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2956.0 BP_3 5.00 0.84 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2958.1 BP_3 3.00 0.51 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-296.0 BP_3 3.00 0.96 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2976.1 BP_3 6.00 0.41 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2980.0 BP_3 12.00 1.46 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2986.0 BP_3 3.00 0.47 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2987.0 BP_3 9.00 0.75 867 607358565 EZA52959.1 318 7.5e-27 hypothetical protein X777_07636 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2995.0 BP_3 6.00 0.95 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3.0 BP_3 42.00 2.49 1104 171473646 YP_001798478.1 1311 6.8e-142 cytochrome b (mitochondrion) [Cryptopygus antarcticus]>gi|154100268|gb|ABS57576.1| cytochrome b (mitochondrion) [Cryptopygus antarcticus] 787593012 KP637168.1 125 1.59814e-56 Fenneropenaeus merguiensis mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 P07704 1238 8.2e-135 Cytochrome b OS=Drosophila yakuba GN=mt:Cyt-b PE=3 SV=1 PF01292//PF00033 Prokaryotic cytochrome b561//Cytochrome b/b6/petB GO:0006118//GO:0022904 obsolete electron transport//respiratory electron transport chain GO:0046872//GO:0009055//GO:0016491 metal ion binding//electron carrier activity//oxidoreductase activity GO:0005739//GO:0016020//GO:0070469//GO:0016021 mitochondrion//membrane//respiratory chain//integral component of membrane KOG4663 Cytochrome b Cluster-30.0 BP_3 14.00 2.55 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3003.0 BP_3 2.00 0.51 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3004.0 BP_3 3.00 0.96 442 114554887 XP_001142336.1 173 2.5e-10 PREDICTED: CAMPATH-1 antigen [Pan troglodytes]>gi|397476197|ref|XP_003809496.1| PREDICTED: CAMPATH-1 antigen [Pan paniscus]>gi|426328474|ref|XP_004025277.1| PREDICTED: CAMPATH-1 antigen [Gorilla gorilla gorilla] 68342029 NM_001803.2 436 0 Homo sapiens CD52 molecule (CD52), mRNA >gnl|BL_ORD_ID|1403156 Homo sapiens epididymis secretory sperm binding protein Li 171mP (HEL-S-171mP) mRNA, complete cds K06488 CDW52 CDW52 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06488 P31358 173 1.0e-11 CAMPATH-1 antigen OS=Homo sapiens GN=CD52 PE=1 SV=1 PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-3013.0 BP_3 5.00 0.45 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3020.0 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3022.0 BP_3 2.00 0.47 497 861615602 KMQ86152.1 178 7.4e-11 retrovirus-related pol polyprotein from transposon tnt 1-94 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3031.0 BP_3 4.00 0.49 683 641657806 XP_008180482.1 165 3.3e-09 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3037.0 BP_3 3.00 0.35 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-304.0 BP_3 5.73 0.48 863 642933000 XP_008197222.1 1256 1.3e-135 PREDICTED: dynein heavy chain 3, axonemal [Tribolium castaneum] 597754082 XM_007238795.1 122 5.7607e-55 PREDICTED: Astyanax mexicanus dynein heavy chain 3, axonemal-like (LOC103035185), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8TD57 891 1.1e-94 Dynein heavy chain 3, axonemal OS=Homo sapiens GN=DNAH3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-305.0 BP_3 3.00 0.46 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3052.0 BP_3 1.00 0.33 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-306.0 BP_3 5.00 1.40 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04517 Microvirus lysis protein (E), C terminus GO:0019054 modulation by virus of host process GO:0004857 enzyme inhibitor activity -- -- -- -- Cluster-3076.0 BP_3 1.00 1.52 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-309.0 BP_3 1.27 0.37 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02902 Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- -- -- Cluster-31.0 BP_3 44.00 5.14 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3101.0 BP_3 3.63 0.37 770 91083843 XP_973852.1 445 1.3e-41 PREDICTED: larval cuticle protein LCP-30 [Tribolium castaneum]>gi|270006765|gb|EFA03213.1| hypothetical protein TcasGA2_TC013133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08738 259 1.9e-21 Larval cuticle protein LCP-30 OS=Bombyx mori GN=LCP30 PE=1 SV=2 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-3109.0 BP_3 5.00 0.44 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3113.0 BP_3 4.00 0.34 852 189236761 XP_001815719.1 350 1.4e-30 PREDICTED: uncharacterized protein LOC100141727 [Tribolium castaneum]>gi|270006198|gb|EFA02646.1| hypothetical protein TcasGA2_TC008367 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3125.0 BP_3 4.00 0.67 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3128.0 BP_3 5.00 1.75 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3129.0 BP_3 8.00 1.10 641 297303223 XP_001119465.2 351 8.3e-31 PREDICTED: eukaryotic translation initiation factor 5B-like, partial [Macaca mulatta] 302422495 XM_003009032.1 486 0 Verticillium albo-atrum VaMs.102 eukaryotic translation initiation factor 5B, mRNA K03243 EIF5B translation initiation factor 5B http://www.genome.jp/dbget-bin/www_bget?ko:K03243 Q10251 440 1.6e-42 Eukaryotic translation initiation factor 5B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC56F8.03 PE=1 SV=1 PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid KOG1144 Translation initiation factor 5B (eIF-5B) Cluster-3149.0 BP_3 3.00 0.32 739 478261468 ENN80829.1 269 3.1e-21 hypothetical protein YQE_02736, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01762 Galactosyltransferase GO:0006486 protein glycosylation GO:0008378 galactosyltransferase activity GO:0016020 membrane -- -- Cluster-3164.0 BP_3 2.00 0.42 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3175.0 BP_3 1.00 1.43 312 -- -- -- -- -- 768311754 CP010982.1 312 4.64776e-161 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-318.0 BP_3 1.00 1.16 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-32.0 BP_3 28.00 3.09 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01736//PF03721 Polyomavirus agnoprotein//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GO:0055114 oxidation-reduction process GO:0003677//GO:0016616//GO:0051287 DNA binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- -- -- Cluster-3208.0 BP_3 2.00 1.63 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3217.0 BP_3 4.00 1.52 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3221.0 BP_3 10.54 1.14 736 270005644 EFA02092.1 411 1.0e-37 hypothetical protein TcasGA2_TC007727 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3227.0 BP_3 11.00 0.64 1126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3229.0 BP_3 15.00 0.83 1159 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3237.0 BP_3 8.00 0.82 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3240.0 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3248.0 BP_3 0.55 0.67 321 91083853 XP_974019.1 350 5.4e-31 PREDICTED: endocuticle structural glycoprotein ABD-4 [Tribolium castaneum]>gi|270006761|gb|EFA03209.1| hypothetical protein TcasGA2_TC013129 [Tribolium castaneum] 820859608 XM_003697086.2 33 5.97416e-06 PREDICTED: Apis florea larval cuticle protein 8-like (LOC100867255), mRNA -- -- -- -- Q7M4F3 228 3.1e-18 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-3254.0 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3256.0 BP_3 1.00 0.36 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3261.0 BP_3 5.00 0.42 863 270013879 EFA10327.1 548 1.6e-53 hypothetical protein TcasGA2_TC012544 [Tribolium castaneum] -- -- -- -- -- K16781 TTC8, BBS8 tetratricopeptide repeat protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K16781 Q8TAM2 325 4.7e-29 Tetratricopeptide repeat protein 8 OS=Homo sapiens GN=TTC8 PE=1 SV=2 PF13181//PF13176//PF13414//PF04053//PF13371//PF02259//PF13374//PF00515 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Coatomer WD associated region//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG1129 TPR repeat-containing protein Cluster-3273.0 BP_3 4.00 0.95 495 190702517 ACE75402.1 144 6.5e-07 reverse transcriptase-like protein [Glyptapanteles indiensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3279.0 BP_3 1.45 0.31 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3279.1 BP_3 8.00 0.88 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-328.0 BP_3 3.00 1.15 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3293.0 BP_3 5.00 0.55 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-33.0 BP_3 7.00 2.01 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3300.0 BP_3 3.00 0.55 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3323.0 BP_3 18.00 1.01 1154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3343.1 BP_3 2.00 0.33 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3372.0 BP_3 4.00 1.62 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3380.0 BP_3 3.00 0.71 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3382.0 BP_3 2.00 0.85 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-339.0 BP_3 4.00 0.36 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3390.0 BP_3 2.00 1.75 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3397.1 BP_3 7.00 0.36 1217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-34.0 BP_3 8.00 0.91 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-340.0 BP_3 3.00 0.60 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3400.1 BP_3 8.00 0.91 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3403.0 BP_3 7.00 0.38 1184 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3412.0 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3418.0 BP_3 3.00 0.60 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05115 Cytochrome B6-F complex subunit VI (PetL) GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0009512 cytochrome b6f complex -- -- Cluster-342.0 BP_3 1.00 0.93 336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3422.0 BP_3 4.05 0.32 899 795009131 XP_011860215.1 341 1.7e-29 PREDICTED: putative nuclease HARBI1, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q6AZB8 139 1.8e-07 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-3425.0 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3427.0 BP_3 2.00 0.45 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07694 5TMR of 5TMR-LYT GO:0000160//GO:0071555//GO:0016310 phosphorelay signal transduction system//cell wall organization//phosphorylation GO:0004673//GO:0000155 protein histidine kinase activity//phosphorelay sensor kinase activity GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex -- -- Cluster-3437.0 BP_3 2.00 0.48 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3438.0 BP_3 2.00 0.85 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3438.1 BP_3 11.00 0.54 1276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3455.0 BP_3 2.00 0.41 525 148664717 EDK97133.1 464 5.4e-44 polyadenylate-binding protein-interacting protein 2, isoform CRA_b, partial [Mus musculus] 795529255 XM_011716389.1 501 0 PREDICTED: Macaca nemestrina poly(A) binding protein interacting protein 2 (PAIP2), mRNA -- -- -- -- Q9BPZ3 455 2.4e-44 Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens GN=PAIP2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-3457.0 BP_3 3.00 0.58 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3460.0 BP_3 2.00 0.68 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3463.0 BP_3 2.00 0.35 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3466.0 BP_3 3.00 0.55 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3468.0 BP_3 3.00 0.61 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3475.0 BP_3 43.20 1.41 1768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3476.0 BP_3 4.00 0.54 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3488.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3493.0 BP_3 5.00 0.71 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3494.0 BP_3 1.00 0.44 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3496.0 BP_3 3.00 0.84 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3497.0 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-35.0 BP_3 8.00 1.12 636 91084725 XP_970320.1 242 3.6e-18 PREDICTED: leucine-rich repeat extensin-like protein 5 [Tribolium castaneum]>gi|270008936|gb|EFA05384.1| hypothetical protein TcasGA2_TC015556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3505.0 BP_3 1.00 0.35 430 -- -- -- -- -- 697074593 XM_009653514.1 424 0 Verticillium dahliae VdLs.17 SVP26 protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3506.0 BP_3 2.00 0.55 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3516.0 BP_3 2.00 0.36 558 -- -- -- -- -- 768311755 CP010983.1 523 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3524.0 BP_3 3.00 0.50 580 -- -- -- -- -- 768311752 CP010980.1 558 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3526.0 BP_3 3.00 0.49 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3528.0 BP_3 5.00 0.59 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3531.0 BP_3 1.00 0.38 417 676430863 XP_009046066.1 179 4.7e-11 hypothetical protein LOTGIDRAFT_199394 [Lottia gigantea]>gi|556114615|gb|ESP03267.1| hypothetical protein LOTGIDRAFT_199394 [Lottia gigantea] 768311753 CP010981.1 295 1.80392e-151 Verticillium dahliae VdLs.17 chromosome 2, complete sequence K12405 HSD17B4 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K12405 P80547 232 1.4e-18 Fatty acid-binding protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SCP2 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG4170 2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/Peroxisomal 3-ketoacyl-CoA-thiolase, sterol-binding domain and related enzymes Cluster-3539.0 BP_3 7.00 0.47 1010 189240417 XP_970201.2 450 4.3e-42 PREDICTED: trichohyalin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-354.0 BP_3 5.00 0.86 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3540.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3542.0 BP_3 21.38 0.61 1994 546683920 ERL93666.1 1801 1.9e-198 hypothetical protein D910_10954 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4J913 713 1.1e-73 Facilitated trehalose transporter Tret1 OS=Drosophila grimshawi GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-3555.0 BP_3 3.00 0.88 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3557.0 BP_3 4.00 0.75 548 827552719 XP_012548116.1 161 7.6e-09 PREDICTED: retrovirus-related Pol polyprotein from transposon 17.6 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3563.0 BP_3 2.00 0.95 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3570.0 BP_3 4.00 25.33 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3571.0 BP_3 3.00 0.60 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3583.0 BP_3 2.00 0.75 420 -- -- -- -- -- 90081129 AB172983.1 420 0 Macaca fascicularis brain cDNA clone: QflA-20483, similar to human splicing factor, arginine/serine-rich 5 (SFRS5), mRNA, RefSeq: NM_006925.2 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3585.0 BP_3 1.00 0.86 341 270016783 EFA13229.1 239 4.3e-18 hypothetical protein TcasGA2_TC004269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3590.0 BP_3 1.00 0.48 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3596.1 BP_3 2.00 0.32 591 761906699 XP_011403005.1 925 2.1e-97 PREDICTED: dynein heavy chain 3, axonemal [Amphimedon queenslandica] 442630308 NM_139680.3 189 2.20131e-92 Drosophila melanogaster CG17150 (CG17150), transcript variant D, mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8BW94 898 1.2e-95 Dynein heavy chain 3, axonemal OS=Mus musculus GN=Dnah3 PE=2 SV=2 PF07728//PF02224//PF00004//PF00910 AAA domain (dynein-related subfamily)//Cytidylate kinase//ATPase family associated with various cellular activities (AAA)//RNA helicase GO:0006206//GO:0006139 pyrimidine nucleobase metabolic process//nucleobase-containing compound metabolic process GO:0005524//GO:0003723//GO:0004127//GO:0016887//GO:0003724 ATP binding//RNA binding//cytidylate kinase activity//ATPase activity//RNA helicase activity -- -- -- -- Cluster-3599.0 BP_3 4.00 0.68 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-36.0 BP_3 7.19 0.85 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-360.0 BP_3 16.00 2.98 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3610.0 BP_3 10.00 0.48 1300 768415310 XP_011548199.1 249 1.1e-18 PREDICTED: uncharacterized protein LOC105380367 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-3614.0 BP_3 4.00 0.44 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3618.0 BP_3 1.00 1.01 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-362.0 BP_3 20.88 2.87 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-363.0 BP_3 3.00 0.32 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3636.0 BP_3 2.00 0.38 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-364.0 BP_3 1.00 0.36 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3643.0 BP_3 5.00 0.57 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3645.0 BP_3 3.00 0.39 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3646.0 BP_3 3.00 0.36 698 751211261 XP_011158361.1 174 3.0e-10 PREDICTED: uncharacterized protein LOC105194922 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3647.0 BP_3 1.00 0.64 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3657.0 BP_3 2.00 0.32 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3660.0 BP_3 2.00 0.84 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3661.0 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3663.0 BP_3 1.00 0.44 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3664.0 BP_3 1.00 0.78 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3677.0 BP_3 2.00 0.63 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3684.0 BP_3 4.00 0.52 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3687.0 BP_3 3.00 0.38 670 270016782 EFA13228.1 985 2.6e-104 hypothetical protein TcasGA2_TC004268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 730 4.0e-76 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-3694.0 BP_3 1.00 0.43 402 847153933 XP_012823710.1 593 4.5e-59 PREDICTED: tubulin beta chain isoform X1 [Xenopus (Silurana) tropicalis] 649106156 KJ893022.1 402 0 Synthetic construct Homo sapiens clone ccsbBroadEn_02416 TUBB4B gene, encodes complete protein K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 P69895 593 1.9e-60 Tubulin beta chain OS=Macaca mulatta GN=TUBB PE=2 SV=1 PF04816//PF00091 tRNA (adenine(22)-N(1))-methyltransferase//Tubulin/FtsZ family, GTPase domain GO:0009451//GO:0008033 RNA modification//tRNA processing GO:0016429//GO:0003924 tRNA (adenine-N1-)-methyltransferase activity//GTPase activity -- -- KOG1375 Beta tubulin Cluster-3697.0 BP_3 1.00 0.39 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3698.0 BP_3 4.57 0.58 669 642935504 XP_008198037.1 329 3.1e-28 PREDICTED: rap guanine nucleotide exchange factor 4 isoform X4 [Tribolium castaneum] -- -- -- -- -- K04351 RAPGEF4, EPAC2 Rap guanine nucleotide exchange factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04351 Q8WZA2 275 2.3e-23 Rap guanine nucleotide exchange factor 4 OS=Homo sapiens GN=RAPGEF4 PE=1 SV=1 PF00617 RasGEF domain GO:0007264//GO:0043087 small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG2378 cAMP-regulated guanine nucleotide exchange factor Cluster-37.0 BP_3 60.00 2.75 1342 171473636 YP_001798468.1 1826 1.6e-201 cytochrome c oxidase subunit I (mitochondrion) [Cryptopygus antarcticus]>gi|154100258|gb|ABS57566.1| cytochrome c oxidase subunit I (mitochondrion) [Cryptopygus antarcticus] 755469011 KM610087.1 416 0 Entomobrya ligata voucher 11-33-li-3 cytochrome oxidase subunit 1 (COI) gene, partial cds; mitochondrial K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 Q34391 1638 4.1e-181 Cytochrome c oxidase subunit 1 OS=Drosophila sechellia GN=mt:CoI PE=3 SV=2 PF00115 Cytochrome C and Quinol oxidase polypeptide I GO:0006123//GO:0009060//GO:0006119//GO:0006118//GO:0022900//GO:0015992//GO:0055114 mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration//oxidative phosphorylation//obsolete electron transport//electron transport chain//proton transport//oxidation-reduction process GO:0009055//GO:0004129//GO:0020037//GO:0005506 electron carrier activity//cytochrome-c oxidase activity//heme binding//iron ion binding GO:0016021//GO:0070469//GO:0005743//GO:0045277 integral component of membrane//respiratory chain//mitochondrial inner membrane//respiratory chain complex IV KOG4769 Cytochrome c oxidase, subunit I Cluster-3701.0 BP_3 8.00 0.64 896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3708.0 BP_3 2.00 0.32 592 642927203 XP_008195178.1 181 3.9e-11 PREDICTED: DNA mismatch repair protein MLH3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01119//PF05866 DNA mismatch repair protein, C-terminal domain//Endodeoxyribonuclease RusA GO:0006281//GO:0006310//GO:0006298 DNA repair//DNA recombination//mismatch repair GO:0000287//GO:0005524//GO:0030983 magnesium ion binding//ATP binding//mismatched DNA binding -- -- -- -- Cluster-3714.0 BP_3 3.00 1.04 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3720.0 BP_3 4.00 0.54 650 -- -- -- -- -- 768311756 CP010984.1 576 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3721.0 BP_3 1.00 0.54 379 768428884 XP_011555598.1 186 6.6e-12 PREDICTED: zinc finger CW-type PWWP domain protein 1-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3729.0 BP_3 1.00 0.42 404 670986342 XP_008684233.1 402 6.3e-37 PREDICTED: LOW QUALITY PROTEIN: polyubiquitin-B [Ursus maritimus] 528524478 NM_001281720.1 314 4.7777e-162 Homo sapiens ubiquitin B (UBB), transcript variant 6, mRNA K04551 UBB ubiquitin B http://www.genome.jp/dbget-bin/www_bget?ko:K04551 P0CG60 394 2.2e-37 Polyubiquitin-B OS=Pongo pygmaeus GN=UBB PE=3 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-3730.0 BP_3 2.00 0.75 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3742.1 BP_3 2.00 0.67 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3756.0 BP_3 2.00 0.34 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3761.0 BP_3 9.00 0.47 1224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3765.0 BP_3 5.45 0.39 973 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3777.0 BP_3 1.00 0.37 421 -- -- -- -- -- 462335013 APGK01038383.1 56 1.31852e-18 Dendroctonus ponderosae Seq01038393, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3777.2 BP_3 3.00 2.41 346 -- -- -- -- -- 462335013 APGK01038383.1 66 2.9365e-24 Dendroctonus ponderosae Seq01038393, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF16785 Small metal-binding protein -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-3778.0 BP_3 1.00 0.31 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3779.0 BP_3 6.00 0.52 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3780.0 BP_3 6.35 1.12 566 478251152 ENN71628.1 591 1.1e-58 hypothetical protein YQE_11727, partial [Dendroctonus ponderosae]>gi|546685814|gb|ERL95257.1| hypothetical protein D910_12524 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A0JNG4 269 9.7e-23 RING finger protein 207 OS=Bos taurus GN=RNF207 PE=2 SV=1 PF14634//PF00097//PF13639 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-3781.0 BP_3 4.00 0.88 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3798.0 BP_3 2.00 0.64 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-38.0 BP_3 7.00 2.00 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05309 TraE protein GO:0000746 conjugation -- -- -- -- -- -- Cluster-3800.0 BP_3 9.23 1.00 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3801.0 BP_3 2.00 0.58 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3805.0 BP_3 4.00 0.52 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3806.0 BP_3 3.00 0.74 486 531445261 AGT57839.1 195 7.7e-13 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V6D6 126 3.2e-06 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-3817.0 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-382.0 BP_3 5.00 1.54 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3822.1 BP_3 4.00 0.60 613 768434794 XP_011558817.1 236 1.7e-17 PREDICTED: uncharacterized protein LOC105389412 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3825.1 BP_3 3.00 1.16 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3828.0 BP_3 1.00 3.39 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3833.0 BP_3 10.69 1.08 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3842.0 BP_3 3.00 0.32 742 478256088 ENN76287.1 330 2.6e-28 hypothetical protein YQE_07250, partial [Dendroctonus ponderosae]>gi|546675829|gb|ERL86934.1| hypothetical protein D910_04337 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05499//PF01166 DNA methyltransferase 1-associated protein 1 (DMAP1)//TSC-22/dip/bun family GO:0006355//GO:0045892 regulation of transcription, DNA-templated//negative regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-3844.0 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3847.1 BP_3 3.00 0.36 699 805827472 XP_012153565.1 182 3.6e-11 PREDICTED: piggyBac transposable element-derived protein 4-like, partial [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-385.0 BP_3 3.00 0.40 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3851.0 BP_3 6.00 0.76 673 546685946 ERL95360.1 372 3.2e-33 hypothetical protein D910_12625 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3853.0 BP_3 1.00 0.31 446 321477015 EFX87974.1 607 1.2e-60 hypothetical protein DAPPUDRAFT_305638 [Daphnia pulex] 831239344 XM_003797995.2 175 9.89623e-85 PREDICTED: Otolemur garnettii tubulin, beta 4A class IVa (TUBB4A), transcript variant X10, mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q6VAF6 605 8.3e-62 Tubulin beta-6 chain OS=Gossypium hirsutum PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1375 Beta tubulin Cluster-3860.0 BP_3 2.00 3.10 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3867.0 BP_3 6.00 1.85 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3868.0 BP_3 3.00 0.41 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-387.0 BP_3 3.00 0.47 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3870.0 BP_3 4.00 0.35 836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3873.0 BP_3 1.00 0.36 423 642915636 XP_008190692.1 183 1.6e-11 PREDICTED: orthodenticle-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3880.0 BP_3 3.00 0.70 498 546675803 ERL86918.1 384 9.6e-35 hypothetical protein D910_04321 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IY82 263 4.2e-22 Dynein regulatory complex subunit 7 OS=Homo sapiens GN=DRC7 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-3884.1 BP_3 3.00 0.41 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3889.0 BP_3 3.99 0.53 651 270015134 EFA11582.1 507 6.8e-49 serine protease P100 [Tribolium castaneum] -- -- -- -- -- K09614 CORIN corin http://www.genome.jp/dbget-bin/www_bget?ko:K09614 Q16651 203 5.0e-15 Prostasin OS=Homo sapiens GN=PRSS8 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-389.0 BP_3 4.00 0.72 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3895.0 BP_3 3.00 0.32 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-39.0 BP_3 4.00 1.14 460 668457813 KFB45803.1 296 1.4e-24 AGAP006829-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- P82166 272 3.5e-23 Cuticle protein 19.8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-3903.0 BP_3 3.00 0.53 564 546684070 ERL93793.1 793 4.1e-82 hypothetical protein D910_11079, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N5T2 486 6.7e-48 TBC1 domain family member 19 OS=Homo sapiens GN=TBC1D19 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-3916.0 BP_3 2.00 0.39 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-392.0 BP_3 2.00 0.32 591 328697481 XP_003240351.1 146 4.5e-07 PREDICTED: uncharacterized protein LOC100573963 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3920.0 BP_3 2.00 0.51 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3928.0 BP_3 16.00 0.64 1503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-393.0 BP_3 3.00 0.49 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3935.0 BP_3 2.00 0.33 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3936.1 BP_3 4.00 0.55 640 642919057 XP_008191716.1 187 8.6e-12 PREDICTED: protein atonal homolog 7-like [Tribolium castaneum]>gi|270005722|gb|EFA02170.1| hypothetical protein TcasGA2_TC007826 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-3938.0 BP_3 4.00 0.92 502 262401277 ACY66541.1 246 9.7e-19 hypothetical protein [Scylla paramamosain] 262401276 FJ774820.1 357 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3940.0 BP_3 1.00 1.06 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3949.0 BP_3 3.00 1.12 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3950.0 BP_3 5.00 0.78 599 270011961 EFA08409.1 184 1.8e-11 hypothetical protein TcasGA2_TC006056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00804//PF03079 Syntaxin//ARD/ARD' family GO:0055114 oxidation-reduction process GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity GO:0016020 membrane -- -- Cluster-3952.0 BP_3 5.00 1.38 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02459 Adenoviral DNA terminal protein GO:0006260 DNA replication GO:0003677 DNA binding -- -- -- -- Cluster-3954.0 BP_3 7.00 2.11 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3957.0 BP_3 5.00 0.40 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3957.1 BP_3 8.00 0.64 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3968.0 BP_3 1.00 0.33 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3970.0 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-398.0 BP_3 5.00 0.47 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3981.0 BP_3 3.00 0.70 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3982.0 BP_3 17.95 0.59 1768 642926446 XP_008191962.1 1543 1.4e-168 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009089|gb|EFA05537.1| hypothetical protein TcasGA2_TC015724 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 768 4.2e-80 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF07992//PF05834//PF00732//PF01266//PF05199 Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase GO:0016117//GO:0044710//GO:0055114 carotenoid biosynthetic process//single-organism metabolic process//oxidation-reduction process GO:0050660//GO:0016705//GO:0016614//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity -- -- -- -- Cluster-3985.0 BP_3 3.00 0.89 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4.0 BP_3 10.00 2.56 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06377 Adipokinetic hormone GO:0007165 signal transduction GO:0005179 hormone activity -- -- -- -- Cluster-40.0 BP_3 30.00 2.71 825 171473639 YP_001798471.1 611 7.6e-61 ATP synthase F0 subunit 6 (mitochondrion) [Cryptopygus antarcticus]>gi|154100261|gb|ABS57569.1| ATP synthase F0 subunit 6 (mitochondrion) [Cryptopygus antarcticus] -- -- -- -- -- K02126 ATPeF0A, MTATP6, ATP6 F-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02126 P00851 554 1.3e-55 ATP synthase subunit a OS=Drosophila yakuba GN=mt:ATPase6 PE=3 SV=1 PF00119 ATP synthase A chain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0044424 intracellular part KOG4665 ATP synthase F0 subunit 6 and related proteins Cluster-4003.0 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4004.0 BP_3 1.00 0.80 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4006.0 BP_3 5.00 0.42 859 270010054 EFA06502.1 746 1.7e-76 hypothetical protein TcasGA2_TC009401 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT34 272 6.6e-23 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-4008.0 BP_3 2.00 0.45 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4024.0 BP_3 8.00 1.93 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4026.0 BP_3 3.00 0.41 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-403.0 BP_3 2.00 2.80 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09181 Prolyl-tRNA synthetase, C-terminal GO:0006560//GO:0006525//GO:0006433 proline metabolic process//arginine metabolic process//prolyl-tRNA aminoacylation GO:0000166//GO:0004827//GO:0005524 nucleotide binding//proline-tRNA ligase activity//ATP binding GO:0005737 cytoplasm -- -- Cluster-4031.0 BP_3 2.00 0.35 571 755979284 XP_011308853.1 392 1.3e-35 PREDICTED: solute carrier family 23 member 2 [Fopius arisanus] -- -- -- -- -- K14611 SLC23A1_2, SVCT1_2 solute carrier family 23 (nucleobase transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14611 Q9EPR4 290 3.6e-25 Solute carrier family 23 member 2 OS=Mus musculus GN=Slc23a2 PE=1 SV=2 PF00860 Permease family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG1292 Xanthine/uracil transporters Cluster-4035.0 BP_3 1.00 0.32 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02527 rRNA small subunit methyltransferase G GO:0006364//GO:0006396//GO:0000154 rRNA processing//RNA processing//rRNA modification GO:0008649 rRNA methyltransferase activity GO:0005737 cytoplasm -- -- Cluster-4036.0 BP_3 11.00 0.61 1163 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-4038.0 BP_3 1.00 0.49 389 591344094 XP_007097380.1 525 3.3e-51 PREDICTED: small nuclear ribonucleoprotein Sm D2 [Panthera tigris altaica] 530417092 XM_005259180.1 389 0 PREDICTED: Homo sapiens small nuclear ribonucleoprotein D2 polypeptide 16.5kDa (SNRPD2), transcript variant X1, mRNA K11096 SNRPD2, SMD2 small nuclear ribonucleoprotein D2 http://www.genome.jp/dbget-bin/www_bget?ko:K11096 Q3SZF8 521 4.0e-52 Small nuclear ribonucleoprotein Sm D2 OS=Bos taurus GN=SNRPD2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3459 Small nuclear ribonucleoprotein (snRNP) Sm core protein Cluster-4040.0 BP_3 1.00 4.17 269 767908770 XP_011507631.1 240 2.6e-18 PREDICTED: filaggrin isoform X1 [Homo sapiens] 767908769 XM_011509329.1 238 5.38176e-120 PREDICTED: Homo sapiens filaggrin (FLG), transcript variant X1, mRNA -- -- -- -- P20930 240 1.1e-19 Filaggrin OS=Homo sapiens GN=FLG PE=1 SV=3 PF03516 Filaggrin -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-4050.0 BP_3 5.00 0.32 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4052.0 BP_3 2.00 0.34 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4056.0 BP_3 5.00 1.55 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4073.0 BP_3 8.00 0.73 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4076.0 BP_3 6.00 0.54 823 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4078.0 BP_3 3.00 0.43 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4084.0 BP_3 12.45 0.78 1059 270010676 EFA07124.1 239 1.3e-17 hypothetical protein TcasGA2_TC010115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06005//PF00170//PF06320//PF09728//PF04111//PF07851//PF04977 Protein of unknown function (DUF904)//bZIP transcription factor//GCN5-like protein 1 (GCN5L1)//Myosin-like coiled-coil protein//Autophagy protein Apg6//TMPIT-like protein//Septum formation initiator GO:0006914//GO:0007049//GO:0043093//GO:0000917//GO:0006355 autophagy//cell cycle//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of transcription, DNA-templated GO:0019905//GO:0003700//GO:0043565 syntaxin binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021//GO:0031083//GO:0005737 transcription factor complex//integral component of membrane//BLOC-1 complex//cytoplasm -- -- Cluster-4086.0 BP_3 4.00 1.84 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4087.0 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4088.0 BP_3 1.50 0.49 438 270017042 EFA13488.1 232 3.6e-17 hypothetical protein TcasGA2_TC004227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4091.0 BP_3 1.00 0.46 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4093.0 BP_3 4.00 0.87 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4096.0 BP_3 3.00 0.48 590 861641601 KMQ93606.1 182 3.0e-11 nuclear valosin-containing [Lasius niger] -- -- -- -- -- -- -- -- -- P16425 167 6.8e-11 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF06457 Ectatomin GO:0009405//GO:0006811 pathogenesis//ion transport GO:0005216 ion channel activity GO:0005576 extracellular region -- -- Cluster-41.0 BP_3 5.00 1.28 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4105.0 BP_3 3.00 0.55 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4107.0 BP_3 6.13 0.73 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4112.0 BP_3 7.00 0.58 875 270015465 EFA11913.1 422 6.6e-39 hypothetical protein TcasGA2_TC004070 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4114.0 BP_3 2.00 0.50 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4130.0 BP_3 3.00 0.47 602 805782442 XP_012139562.1 268 3.3e-21 PREDICTED: protein daughterless isoform X11 [Megachile rotundata] -- -- -- -- -- K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P51514 199 1.3e-14 Transcription factor 12 OS=Rattus norvegicus GN=Tcf12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-4135.0 BP_3 5.00 1.28 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4145.0 BP_3 3.84 0.33 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4148.0 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4151.0 BP_3 2.00 0.58 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4152.0 BP_3 2.00 0.35 565 183637075 ACC64544.1 599 1.3e-59 dynein light chain 1 (predicted) [Rhinolophus ferrumequinum] 426374393 XM_004054011.1 564 0 PREDICTED: Gorilla gorilla gorilla dynein, light chain, LC8-type 1, transcript variant 2 (DYNLL1), mRNA K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 P63170 478 5.6e-47 Dynein light chain 1, cytoplasmic OS=Rattus norvegicus GN=Dynll1 PE=1 SV=1 PF01221//PF00443 Dynein light chain type 1//Ubiquitin carboxyl-terminal hydrolase GO:0007017//GO:0016579 microtubule-based process//protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-4159.0 BP_3 2.00 1.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4168.1 BP_3 4.00 3.67 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4169.0 BP_3 1.00 0.71 355 546672885 ERL84608.1 291 4.2e-24 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 228 3.5e-18 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- -- -- Cluster-4172.0 BP_3 2.00 0.40 534 861602714 KMQ83970.1 288 1.4e-23 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-4174.0 BP_3 2.00 0.40 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4176.0 BP_3 3.00 0.32 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4183.0 BP_3 5.00 1.80 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4185.0 BP_3 2.00 0.44 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4192.0 BP_3 3.00 0.43 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4194.0 BP_3 5.00 0.47 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4196.0 BP_3 34.00 1.59 1324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4199.0 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-42.0 BP_3 7.00 1.24 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4206.0 BP_3 3.00 0.44 624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4207.0 BP_3 5.00 0.51 767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4207.1 BP_3 1.00 0.54 378 270016479 EFA12925.1 202 9.3e-14 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] 642939405 XM_008195063.1 80 5.34008e-32 PREDICTED: Tribolium castaneum uncharacterized LOC661130 (LOC661130), mRNA -- -- -- -- -- -- -- -- PF12634 Inheritance of peroxisomes protein 1 GO:0045033 peroxisome inheritance -- -- GO:0005780 extrinsic component of intraperoxisomal membrane -- -- Cluster-4208.0 BP_3 1.00 0.57 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4209.0 BP_3 1.00 3.30 277 817199090 XP_012275214.1 423 1.6e-39 PREDICTED: uncharacterized protein LOC105696933 isoform X1 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01522 Polysaccharide deacetylase GO:0005975//GO:0006807 carbohydrate metabolic process//nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-4216.0 BP_3 2.00 0.41 526 358256990 GAA58062.1 567 6.1e-56 2-methylcitrate dehydratase, partial [Clonorchis sinensis] 768311753 CP010981.1 493 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- Q8X693 567 2.5e-57 2-methylcitrate dehydratase OS=Escherichia coli O157:H7 GN=prpD PE=3 SV=3 PF03972 MmgE/PrpD family -- -- GO:0016829 lyase activity -- -- -- -- Cluster-4216.1 BP_3 2.00 1.70 342 669219205 CDW59492.1 337 1.8e-29 AMP-binding C and MmgE PrpD and AMP-binding domai n containing protein [Trichuris trichiura] 768311753 CP010981.1 342 1.08315e-177 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- Q937N6 347 5.3e-32 2-methylcitrate dehydratase OS=Cupriavidus necator GN=prpD PE=3 SV=1 PF03972 MmgE/PrpD family -- -- GO:0016829 lyase activity -- -- -- -- Cluster-4218.0 BP_3 2.00 0.32 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4220.2 BP_3 4.00 0.66 582 642917399 XP_008191180.1 393 1.0e-35 PREDICTED: uncharacterized protein LOC103312409 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4221.0 BP_3 2.00 1.17 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-423.0 BP_3 2.00 0.65 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4248.0 BP_3 2.00 1.23 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4248.2 BP_3 2.00 0.49 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4254.0 BP_3 30.00 0.75 2214 828220188 XP_012561527.1 346 1.1e-29 PREDICTED: uncharacterized protein LOC105846912, partial [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03094//PF03184//PF01527//PF02796//PF05225 Mlo family//DDE superfamily endonuclease//Transposase//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain GO:0006310//GO:0006313//GO:0006952 DNA recombination//transposition, DNA-mediated//defense response GO:0003676//GO:0004803//GO:0003677//GO:0000150 nucleic acid binding//transposase activity//DNA binding//recombinase activity GO:0016021 integral component of membrane -- -- Cluster-4258.0 BP_3 1.00 0.33 437 675370125 KFM63027.1 348 1.3e-30 Hormone receptor 4, partial [Stegodyphus mimosarum] -- -- -- -- -- K08027 NR5A2, FTF nuclear receptor subfamily 5 group A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08027 Q9W539 331 4.8e-30 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00105 Zinc finger, C4 type (two domains) GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-4260.0 BP_3 2.00 0.80 411 342326382 AEL23106.1 309 3.9e-26 hnRNP protein [Cherax quadricarinatus] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 Q08170 240 1.6e-19 Serine/arginine-rich splicing factor 4 OS=Homo sapiens GN=SRSF4 PE=1 SV=2 PF08777//PF00076//PF05091//PF09726//PF01080 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)//Transmembrane protein//Presenilin GO:0006446 regulation of translational initiation GO:0004190//GO:0003743//GO:0003723//GO:0003676 aspartic-type endopeptidase activity//translation initiation factor activity//RNA binding//nucleic acid binding GO:0016021//GO:0005737//GO:0005852//GO:0005840 integral component of membrane//cytoplasm//eukaryotic translation initiation factor 3 complex//ribosome KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-4275.0 BP_3 5.00 0.46 819 861625527 KMQ88569.1 441 3.9e-41 retrovirus-like pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P27401 264 5.3e-22 Pro-Pol polyprotein OS=Simian foamy virus type 3 (strain LK3) GN=pol PE=3 SV=2 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-4284.0 BP_3 5.00 0.50 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4285.0 BP_3 4.00 0.39 782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4295.0 BP_3 6.00 0.47 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-43.0 BP_3 13.00 1.58 689 157106865 XP_001649519.1 176 1.7e-10 AAEL004648-PA [Aedes aegypti]>gi|108879752|gb|EAT43977.1| AAEL004648-PA [Aedes aegypti] -- -- -- -- -- K09083 ATOH1_7 atonal protein 1/7 http://www.genome.jp/dbget-bin/www_bget?ko:K09083 Q8N100 149 9.7e-09 Protein atonal homolog 7 OS=Homo sapiens GN=ATOH7 PE=1 SV=1 PF00472//PF00010 RF-1 domain//Helix-loop-helix DNA-binding domain GO:0006449//GO:0006415 regulation of translational termination//translational termination GO:0003747//GO:0046983 translation release factor activity//protein dimerization activity GO:0005840//GO:0018444 ribosome//translation release factor complex KOG4395 Transcription factor Atonal, contains HTH domain Cluster-4303.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4304.0 BP_3 1.00 0.35 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01991 ATP synthase (E/31 kDa) subunit GO:0015991//GO:0015992//GO:0006119 ATP hydrolysis coupled proton transport//proton transport//oxidative phosphorylation GO:0046961 proton-transporting ATPase activity, rotational mechanism GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-4314.0 BP_3 4.00 0.46 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02044 Bombesin-like peptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-4328.1 BP_3 3.00 0.39 659 642913216 XP_008201442.1 260 3.0e-20 PREDICTED: uncharacterized protein LOC664132 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4335.0 BP_3 2.00 1.96 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4346.0 BP_3 13.81 0.35 2168 242012953 XP_002427188.1 558 2.8e-54 conserved hypothetical protein [Pediculus humanus corporis]>gi|212511475|gb|EEB14450.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q75V66 154 8.0e-09 Anoctamin-5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-4347.1 BP_3 6.00 0.33 1159 91090578 XP_976368.1 539 2.4e-52 PREDICTED: uncharacterized protein LOC661071 isoform X1 [Tribolium castaneum]>gi|270013341|gb|EFA09789.1| hypothetical protein TcasGA2_TC011931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4353.0 BP_3 2.00 0.37 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15184 Mitochondrial import receptor subunit TOM6 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-4359.0 BP_3 8.00 0.85 746 642915456 XP_008190624.1 786 3.5e-81 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC662365 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-436.0 BP_3 4.00 0.51 670 91094979 XP_971439.1 303 3.2e-25 PREDICTED: protein Wnt-8a isoform X1 [Tribolium castaneum]>gi|270015290|gb|EFA11738.1| hypothetical protein TcasGA2_TC002386 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H1J5 204 4.0e-15 Protein Wnt-8a OS=Homo sapiens GN=WNT8A PE=2 SV=2 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-438.0 BP_3 2.00 0.78 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-438.1 BP_3 6.00 0.40 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4381.0 BP_3 2.00 0.40 531 768410542 XP_011558838.1 540 8.3e-53 PREDICTED: aquaporin-12 isoform X2 [Plutella xylostella] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 -- -- -- -- PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-4386.0 BP_3 3.00 1.70 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4388.0 BP_3 3.00 0.35 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4391.1 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4399.0 BP_3 1.00 1.12 325 861588173 KMQ82585.1 166 1.2e-09 transposase-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-44.0 BP_3 6.00 1.75 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4405.0 BP_3 5.00 0.48 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4405.2 BP_3 1.00 1.30 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434//PF08046 TMEM9//IlvGEDA operon leader peptide GO:0009082 branched-chain amino acid biosynthetic process -- -- GO:0016021 integral component of membrane -- -- Cluster-4410.1 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4411.0 BP_3 10.16 2.99 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4424.0 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4430.0 BP_3 5.00 0.36 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4431.0 BP_3 3.00 0.35 703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588 C2H2 zinc-finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-4439.0 BP_3 2.00 0.34 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4441.0 BP_3 7.00 0.31 1380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4447.0 BP_3 2.00 1.42 355 194318458 ACF47617.1 542 3.3e-53 soluble MET variant 15 [Homo sapiens] 212720875 NG_008996.1 351 0 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2IBA6 509 9.0e-51 Hepatocyte growth factor receptor OS=Chlorocebus aethiops GN=MET PE=3 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- KOG3610 Plexins (functional semaphorin receptors) Cluster-445.0 BP_3 2.00 0.42 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4463.1 BP_3 1.00 0.33 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4467.0 BP_3 2.00 0.43 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-447.0 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4470.0 BP_3 3.87 0.37 797 805781319 XP_012139252.1 577 6.4e-57 PREDICTED: Down syndrome cell adhesion molecule-like protein Dscam2 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q9VS29 499 2.9e-49 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF00041//PF13895//PF16656 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-4480.0 BP_3 1.00 0.69 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4483.0 BP_3 5.16 0.44 856 270006486 EFA02934.1 159 2.0e-08 gustatory receptor 101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06151//PF08395 Trehalose receptor//7tm Chemosensory receptor GO:0050909//GO:0007187//GO:0050912//GO:0007607 sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-4489.0 BP_3 1.00 0.61 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-449.0 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4490.0 BP_3 1.47 0.75 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4497.0 BP_3 4.00 0.52 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-45.0 BP_3 4.07 0.39 798 270002934 EEZ99381.1 191 3.7e-12 prothoracicotropic hormone [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-450.0 BP_3 2.00 1.05 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4501.0 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0046813//GO:0061025 receptor-mediated virion attachment to host cell//membrane fusion -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-4504.0 BP_3 4.00 1.02 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4518.0 BP_3 1.00 3.70 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4519.0 BP_3 49.00 1.70 1677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-454.1 BP_3 6.00 0.33 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4542.0 BP_3 1.00 0.33 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4545.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-455.0 BP_3 1.00 0.86 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4568.0 BP_3 4.00 1.50 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4570.0 BP_3 2.00 0.34 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4576.0 BP_3 3.00 1.61 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4586.0 BP_3 3.00 0.94 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-459.0 BP_3 1.00 0.34 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4594.0 BP_3 2.00 0.54 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08597 Translation initiation factor eIF3 subunit GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840//GO:0005737//GO:0005852 ribosome//cytoplasm//eukaryotic translation initiation factor 3 complex -- -- Cluster-4602.0 BP_3 1.00 0.33 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4603.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4607.0 BP_3 2.00 0.58 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4607.1 BP_3 2.00 0.79 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4616.1 BP_3 4.00 0.33 871 752863744 XP_011268239.1 339 2.8e-29 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] 60649821 AJ829764.1 332 1.0624e-171 Otiorhynchus sulcatus partial cbh1 gene for cellulose 1,4-beta-cellobiosidase, six exons -- -- -- -- -- -- -- -- PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-462.0 BP_3 3.00 0.68 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4620.0 BP_3 3.00 0.47 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4639.0 BP_3 4.00 0.49 687 6006555 CAB56793.1 445 1.1e-41 proto-oncogene [Homo sapiens] 212720875 NG_008996.1 517 0 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2IBF2 445 4.6e-43 Hepatocyte growth factor receptor OS=Gorilla gorilla gorilla GN=MET PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-464.0 BP_3 2.00 0.57 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4641.0 BP_3 2.00 0.68 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4645.0 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4645.1 BP_3 8.00 0.52 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4685.0 BP_3 2.00 0.70 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4685.1 BP_3 3.00 0.36 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4697.0 BP_3 9.00 1.02 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4699.0 BP_3 3.00 0.37 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4704.0 BP_3 2.00 0.63 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4708.0 BP_3 9.00 0.36 1497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-471.0 BP_3 9.00 0.58 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-4712.0 BP_3 2.00 0.38 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4714.0 BP_3 2.00 0.37 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4715.0 BP_3 2.50 0.34 641 270001418 EEZ97865.1 305 1.8e-25 hypothetical protein TcasGA2_TC000237 [Tribolium castaneum] 195496647 XM_002095746.1 48 5.77408e-14 Drosophila yakuba GE22592 (Dyak\GE22592), partial mRNA K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 Q15366 156 1.4e-09 Poly(rC)-binding protein 2 OS=Homo sapiens GN=PCBP2 PE=1 SV=1 PF13014//PF00013//PF07650 KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-4730.0 BP_3 2.00 0.31 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4736.0 BP_3 7.00 0.44 1062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4741.0 BP_3 6.00 0.34 1144 751450572 XP_011179573.1 551 9.5e-54 PREDICTED: zinc finger BED domain-containing protein 4-like [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q80WQ9 169 7.7e-11 Zinc finger BED domain-containing protein 4 OS=Mus musculus GN=Zbed4 PE=2 SV=1 PF00645 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region -- -- GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- KOG1121 Tam3-transposase (Ac family) Cluster-4745.0 BP_3 11.00 1.66 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4758.0 BP_3 3.00 0.93 447 645041401 XP_008206546.1 250 3.0e-19 PREDICTED: uncharacterized protein LOC103315298, partial [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4759.0 BP_3 5.00 0.64 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-476.0 BP_3 1.00 3.59 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4765.0 BP_3 1.00 1.35 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4772.0 BP_3 2.00 0.55 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4782.0 BP_3 5.00 0.47 806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4783.0 BP_3 3.00 1.19 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4799.0 BP_3 4.69 0.49 755 478254899 ENN75134.1 482 6.3e-46 hypothetical protein YQE_08314, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H1D0 135 4.5e-07 Transient receptor potential cation channel subfamily V member 6 OS=Homo sapiens GN=TRPV6 PE=1 SV=3 PF00520//PF03323 Ion transport protein//Bacillus/Clostridium GerA spore germination protein GO:0009847//GO:0055085//GO:0006811 spore germination//transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3676 Ca2+-permeable cation channel OSM-9 and related channels (OTRPC family) Cluster-4801.0 BP_3 1.00 0.39 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4810.0 BP_3 67.00 3.41 1240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4810.1 BP_3 25.00 1.66 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4816.0 BP_3 2.00 0.62 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4817.0 BP_3 13.00 0.69 1204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4833.0 BP_3 6.00 0.50 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4833.1 BP_3 3.00 1.12 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4834.0 BP_3 1.00 0.82 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4854.0 BP_3 2.00 0.36 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4855.0 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4868.0 BP_3 1.00 1.20 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4873.1 BP_3 3.00 0.50 582 431891271 ELK02148.1 931 4.2e-98 60S ribosomal protein L11 [Pteropus alecto] 315221150 NM_000975.3 582 0 Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 P62914 930 2.2e-99 60S ribosomal protein L11 OS=Rattus norvegicus GN=Rpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-4875.0 BP_3 7.00 0.41 1111 675364451 KFM57353.1 255 1.9e-19 Zinc finger BED domain-containing protein 5, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P0CF97 149 1.6e-08 Protein FAM200B OS=Homo sapiens GN=FAM200B PE=3 SV=1 PF07442//PF02892 Ponericin//BED zinc finger -- -- GO:0003677 DNA binding GO:0005576 extracellular region -- -- Cluster-4876.0 BP_3 15.50 0.59 1560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4888.0 BP_3 5.00 2.39 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-489.0 BP_3 6.00 2.05 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-49.0 BP_3 5.00 0.99 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4904.0 BP_3 1.00 5.03 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08118 Yeast mitochondrial distribution and morphology (MDM) proteins GO:0007005 mitochondrion organization -- -- GO:0005743 mitochondrial inner membrane -- -- Cluster-4912.0 BP_3 27.87 0.97 1672 478259284 ENN79186.1 1296 5.7e-140 hypothetical protein YQE_04370, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8SWR3 292 6.2e-25 Sex peptide receptor OS=Drosophila melanogaster GN=SPR PE=1 SV=1 PF08530//PF00001 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0008239//GO:0004930 dipeptidyl-peptidase activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-4925.0 BP_3 3.00 0.31 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4928.0 BP_3 2.08 0.42 528 170060461 XP_001865813.1 308 6.6e-26 conserved hypothetical protein [Culex quinquefasciatus]>gi|167878927|gb|EDS42310.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-493.1 BP_3 3.00 0.37 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4932.1 BP_3 2.00 1.01 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4940.0 BP_3 3.00 0.45 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4947.0 BP_3 2.00 0.62 447 642937146 XP_008198711.1 255 7.8e-20 PREDICTED: odorant receptor 9a-like [Tribolium castaneum]>gi|226334900|emb|CAM84012.1| olfactory receptor 14 [Tribolium castaneum]>gi|270001279|gb|EEZ97726.1| odorant receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949 7tm Odorant receptor GO:0007608//GO:0007187 sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-4948.0 BP_3 9.00 0.48 1191 270005383 EFA01831.1 374 3.3e-33 hypothetical protein TcasGA2_TC007433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 133 1.2e-06 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF01758 Acyltransferase family//Sodium Bile acid symporter family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016020 membrane -- -- Cluster-496.0 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4961.0 BP_3 1.00 0.69 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4962.0 BP_3 6.00 0.33 1180 478263497 ENN81852.1 159 2.8e-08 hypothetical protein YQE_01790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4963.0 BP_3 3.00 0.34 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4964.0 BP_3 2.00 0.53 472 795410173 XP_011944853.1 792 4.4e-82 PREDICTED: importin subunit alpha-1 [Cercocebus atys] 767994705 XM_011524783.1 472 0 PREDICTED: Homo sapiens karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2), transcript variant X1, mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 P52292 792 1.8e-83 Importin subunit alpha-1 OS=Homo sapiens GN=KPNA2 PE=1 SV=1 PF00514//PF01749 Armadillo/beta-catenin-like repeat//Importin beta binding domain GO:0006606//GO:0015031 protein import into nucleus//protein transport GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG0166 Karyopherin (importin) alpha Cluster-4967.0 BP_3 4.00 0.43 738 6680297 NP_032324.1 1192 2.9e-128 dnaJ homolog subfamily A member 1 [Mus musculus]>gi|12621094|ref|NP_075223.1| dnaJ homolog subfamily A member 1 [Rattus norvegicus]>gi|258547146|ref|NP_001158143.1| dnaJ homolog subfamily A member 1 [Mus musculus]>gi|258547148|ref|NP_001158144.1| dnaJ homolog subfamily A member 1 [Mus musculus]>gi|564350875|ref|XP_006238161.1| PREDICTED: dnaJ homolog subfamily A member 1 isoform X1 [Rattus norvegicus]>gi|51702257|sp|P63036.1|DNJA1_RAT RecName: Full=DnaJ homolog subfamily A member 1; AltName: Full=DnaJ-like protein 1; AltName: Full=Heat shock protein J2; Short=HSJ-2; Flags: Precursor>gi|51702258|sp|P63037.1|DNJA1_MOUSE RecName: Full=DnaJ homolog subfamily A member 1; AltName: Full=DnaJ protein homolog 2; AltName: Full=Heat shock 40 kDa protein 4; AltName: Full=Heat shock protein J2; Short=HSJ-2; Flags: Precursor>gi|1294830|gb|AAA98855.1| DnaJ-like protein [Rattus norvegicus]>gi|3025864|gb|AAC78597.1| DnaJ-like protein [Mus musculus]>gi|26350209|dbj|BAC38744.1| unnamed protein product [Mus musculus]>gi|34013390|dbj|BAC82111.1| DnaJ (Hsp40) homolog, subfamily A, member 1 [Cricetulus griseus]>gi|34786059|gb|AAH57876.1| DnaJ (Hsp40) homolog, subfamily A, member 1 [Mus musculus]>gi|38304022|gb|AAH62009.1| DnaJ (Hsp40) homolog, subfamily A, member 1 [Rattus norvegicus]>gi|56790038|dbj|BAD82815.1| DnaJ (Hsp40) homolog, subfamily A, member 1 [Mus musculus]>gi|74190993|dbj|BAE39339.1| unnamed protein product [Mus musculus]>gi|74219315|dbj|BAE26788.1| unnamed protein product [Mus musculus]>gi|148673483|gb|EDL05430.1| mCG9817, isoform CRA_a [Mus musculus]>gi|148673484|gb|EDL05431.1| mCG9817, isoform CRA_a [Mus musculus]>gi|148673485|gb|EDL05432.1| mCG9817, isoform CRA_a [Mus musculus]>gi|148673486|gb|EDL05433.1| mCG9817, isoform CRA_a [Mus musculus]>gi|148673487|gb|EDL05434.1| mCG9817, isoform CRA_a [Mus musculus]>gi|149045641|gb|EDL98641.1| DnaJ (Hsp40) homolog, subfamily A, member 1 [Rattus norvegicus]>gi|187957450|gb|AAI58025.1| DnaJ (Hsp40) homolog, subfamily A, member 1 [Mus musculus] 221042357 AK298725.1 738 0 Homo sapiens cDNA FLJ52352 complete cds, highly similar to DnaJ homolog subfamily A member 1 K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 P63036 1192 1.2e-129 DnaJ homolog subfamily A member 1 OS=Rattus norvegicus GN=Dnaja1 PE=1 SV=1 PF06667//PF00684 Phage shock protein B//DnaJ central domain GO:0006457//GO:0042769//GO:0009271//GO:0007165//GO:0009408//GO:0030317//GO:0006260//GO:0030521//GO:0006355//GO:0007283 protein folding//DNA damage response, detection of DNA damage//phage shock//signal transduction//response to heat//sperm motility//DNA replication//androgen receptor signaling pathway//regulation of transcription, DNA-templated//spermatogenesis GO:0031072//GO:0046872//GO:0050750//GO:0005524//GO:0051082 heat shock protein binding//metal ion binding//low-density lipoprotein particle receptor binding//ATP binding//unfolded protein binding GO:0016020//GO:0005737 membrane//cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-4970.0 BP_3 2.00 0.47 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4975.0 BP_3 5.00 0.53 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4979.0 BP_3 5.00 1.43 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4985.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4989.0 BP_3 13.00 0.95 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01252 Signal peptidase (SPase) II GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity GO:0016020 membrane -- -- Cluster-499.0 BP_3 7.79 0.39 1265 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4995.0 BP_3 2.00 0.67 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5.0 BP_3 29.00 4.13 630 1208519 CAA65137.1 869 7.0e-91 cytochrome oxidase II, partial (mitochondrion) [Isotomurus fucicola] 284820278 GU128317.1 131 4.11239e-60 Lepidocyrtus lignorum isolate FR_Ni cytochrome c oxidase subunit II (COII) gene, partial cds; mitochondrial K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P29856 720 5.4e-75 Cytochrome c oxidase subunit 2 OS=Drosophila ambigua GN=mt:CoII PE=3 SV=1 PF00116//PF02790 Cytochrome C oxidase subunit II, periplasmic domain//Cytochrome C oxidase subunit II, transmembrane domain GO:0006123//GO:0015992//GO:0022900 mitochondrial electron transport, cytochrome c to oxygen//proton transport//electron transport chain GO:0005507//GO:0004129 copper ion binding//cytochrome-c oxidase activity GO:0045277//GO:0016021//GO:0016020 respiratory chain complex IV//integral component of membrane//membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-50.0 BP_3 18.00 0.90 1259 270001339 EEZ97786.1 155 8.7e-08 odorant receptor 309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5001.0 BP_3 2.00 0.39 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5008.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5017.1 BP_3 12.00 0.35 1937 611976628 XP_007474775.1 1642 5.0e-180 PREDICTED: tigger transposable element-derived protein 1-like isoform X3 [Monodelphis domestica] -- -- -- -- -- -- -- -- -- Q96MW7 765 1.0e-79 Tigger transposable element-derived protein 1 OS=Homo sapiens GN=TIGD1 PE=1 SV=1 PF04218//PF03184 CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease -- -- GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- KOG3105 DNA-binding centromere protein B (CENP-B) Cluster-5020.0 BP_3 1.00 0.32 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5023.0 BP_3 3.00 1.43 391 533185573 XP_005405818.1 504 9.2e-49 PREDICTED: 60S ribosomal protein L36 [Chinchilla lanigera] 78190468 NM_033643.2 391 0 Homo sapiens ribosomal protein L36 (RPL36), transcript variant 1, mRNA K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 Q5RAZ9 480 2.3e-47 60S ribosomal protein L36 OS=Pongo abelii GN=RPL36 PE=3 SV=3 PF01158 Ribosomal protein L36e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-5025.0 BP_3 2.00 0.36 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5027.0 BP_3 4.00 0.44 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5029.0 BP_3 3.00 2.52 343 668464962 KFB52200.1 395 3.5e-36 AGAP001653-PA-like protein [Anopheles sinensis] -- -- -- -- -- K03934 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03934 Q94511 364 5.7e-34 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND75 PE=2 SV=3 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0009055//GO:0051536 electron carrier activity//iron-sulfur cluster binding -- -- KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit Cluster-504.0 BP_3 2.00 1.05 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5043.0 BP_3 2.00 0.33 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02674 Colicin V production protein GO:0009403 toxin biosynthetic process -- -- GO:0016020 membrane -- -- Cluster-5045.0 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5058.0 BP_3 2.00 0.63 445 847046798 XP_012807765.1 159 1.0e-08 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 721-like [Jaculus jaculus] -- -- -- -- -- -- -- -- -- Q86WZ6 148 8.1e-09 Zinc finger protein 227 OS=Homo sapiens GN=ZNF227 PE=1 SV=1 PF01844//PF16622//PF02892//PF00096//PF13465 HNH endonuclease//zinc-finger C2H2-type//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0003676//GO:0003677//GO:0004519 metal ion binding//nucleic acid binding//DNA binding//endonuclease activity -- -- -- -- Cluster-506.0 BP_3 3.00 0.50 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5069.0 BP_3 1.00 0.48 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5071.0 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5082.0 BP_3 4.00 0.45 722 478250054 ENN70560.1 1040 1.2e-110 hypothetical protein YQE_12735, partial [Dendroctonus ponderosae] 884951659 XM_013133752.1 108 2.89779e-47 PREDICTED: Esox lucius dynein, axonemal, heavy chain 3 (dnah3), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8TD57 730 4.3e-76 Dynein heavy chain 3, axonemal OS=Homo sapiens GN=DNAH3 PE=2 SV=1 PF04347 Flagellar biosynthesis protein, FliO GO:0044781 bacterial-type flagellum organization -- -- GO:0016021 integral component of membrane -- -- Cluster-509.0 BP_3 4.00 0.64 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5094.0 BP_3 10.00 0.66 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5098.1 BP_3 3.00 0.72 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-51.0 BP_3 8.00 4.59 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5107.0 BP_3 3.00 0.92 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5116.0 BP_3 2.00 0.34 576 478259218 ENN79120.1 697 5.6e-71 hypothetical protein YQE_04307, partial [Dendroctonus ponderosae]>gi|546672335|gb|ERL84246.1| hypothetical protein D910_01625, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0WYR6 295 9.5e-26 WD repeat-containing protein on Y chromosome OS=Culex quinquefasciatus GN=WDY PE=3 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-5124.0 BP_3 4.00 0.41 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06324 Pigment-dispersing hormone (PDH) GO:0007165//GO:0009416 signal transduction//response to light stimulus GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-5127.1 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5136.1 BP_3 8.00 0.38 1306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5157.0 BP_3 1.00 0.33 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5168.0 BP_3 14.07 0.78 1162 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5178.0 BP_3 2.00 0.79 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5190.0 BP_3 2.00 0.66 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5196.0 BP_3 2.00 0.84 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5202.0 BP_3 2.00 0.67 436 675386992 KFM79889.1 404 4.0e-37 Dual specificity protein phosphatase 16, partial [Stegodyphus mimosarum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9BY84 308 2.2e-27 Dual specificity protein phosphatase 16 OS=Homo sapiens GN=DUSP16 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5208.0 BP_3 4.00 0.56 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5212.0 BP_3 2.00 0.74 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5212.1 BP_3 1.00 3.39 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5222.0 BP_3 2.00 0.50 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5225.0 BP_3 3.00 1.02 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5230.1 BP_3 8.93 0.40 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5241.0 BP_3 4.00 0.67 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5242.0 BP_3 4.00 0.32 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5255.0 BP_3 4.00 0.84 520 -- -- -- -- -- 258644474 AP009082.1 484 0 Oryza sativa Indica Group DNA, chromosome 8, BAC clone: K0063H06 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5261.0 BP_3 3.00 0.58 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5269.1 BP_3 10.00 0.35 1685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5279.0 BP_3 206.97 10.95 1203 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02304 Scaffold protein B GO:0019069 viral capsid assembly -- -- GO:0046729 viral procapsid -- -- Cluster-5286.0 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5288.0 BP_3 3.00 0.33 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5297.0 BP_3 2.00 0.74 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-53.0 BP_3 26.00 1.36 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-53.1 BP_3 30.00 1.16 1539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02098 Tick histamine binding protein GO:0030682 evasion or tolerance of host defense response GO:0043176 amine binding -- -- -- -- Cluster-5312.0 BP_3 5.00 0.37 937 478250236 ENN70737.1 342 1.3e-29 hypothetical protein YQE_12567, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BDJ4 142 8.6e-08 Lipase member H OS=Oryctolagus cuniculus GN=LIPH PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5318.0 BP_3 7.57 0.50 1018 642918551 XP_008198974.1 884 2.1e-92 PREDICTED: fork head domain-containing protein FD2-like [Tribolium castaneum] 701432873 XM_010006257.1 59 7.18494e-20 PREDICTED: Chaetura pelagica forkhead box protein L1-like (LOC104396420), mRNA K09405 FOXL forkhead box protein L http://www.genome.jp/dbget-bin/www_bget?ko:K09405 Q02360 473 3.9e-46 Fork head domain-containing protein FD2 OS=Drosophila melanogaster GN=fd64A PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-5323.0 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5334.0 BP_3 3.00 0.31 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5348.0 BP_3 2.00 0.85 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-537.0 BP_3 1.00 2.34 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5377.0 BP_3 1.00 3.81 272 759100021 XP_011375277.1 333 4.3e-29 PREDICTED: LOW QUALITY PROTEIN: 40S ribosomal protein S29 [Pteropus vampyrus] 459642366 NM_001032.4 272 6.85353e-139 Homo sapiens ribosomal protein S29 (RPS29), transcript variant 1, mRNA K02980 RP-S29e, RPS29 small subunit ribosomal protein S29e http://www.genome.jp/dbget-bin/www_bget?ko:K02980 P62273 319 7.4e-29 40S ribosomal protein S29 OS=Homo sapiens GN=RPS29 PE=1 SV=2 PF00253 Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3506 40S ribosomal protein S29 Cluster-5394.0 BP_3 3.00 2.19 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-54.0 BP_3 1.00 0.84 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5400.0 BP_3 1.00 0.68 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-542.0 BP_3 3.00 0.44 620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5425.0 BP_3 1.00 0.73 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-543.0 BP_3 2.00 0.62 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5431.0 BP_3 1.00 0.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5433.0 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5450.0 BP_3 1.00 1.18 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5455.0 BP_3 3.00 0.53 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-5458.0 BP_3 8.00 0.82 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-546.0 BP_3 2.00 0.34 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5464.0 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5467.0 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5468.0 BP_3 7.00 0.81 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-547.0 BP_3 9.00 3.10 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-547.1 BP_3 4.00 2.11 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5475.0 BP_3 1.00 0.84 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5482.0 BP_3 2.00 0.64 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5489.0 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5491.0 BP_3 7.00 0.55 901 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5492.0 BP_3 2.00 0.48 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-55.0 BP_3 4.00 0.69 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5505.0 BP_3 2.00 0.77 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5508.0 BP_3 1.00 0.82 345 795014455 XP_011883890.1 148 1.5e-07 PREDICTED: uncharacterized protein LOC105571033 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5515.0 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5518.1 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5522.0 BP_3 6.00 2.21 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5533.0 BP_3 4.00 0.44 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5538.0 BP_3 6.00 0.51 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-555.0 BP_3 1.00 7.02 253 607364331 EZA58543.1 135 3.6e-06 hypothetical protein X777_14705, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5556.0 BP_3 2.00 8.34 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5563.0 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5564.0 BP_3 4.00 0.90 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5579.0 BP_3 2.00 0.51 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5585.0 BP_3 4.00 0.43 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-559.0 BP_3 3.00 0.49 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5591.0 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13292 1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694 terpenoid biosynthetic process//steroid biosynthetic process GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity -- -- -- -- Cluster-5614.0 BP_3 16.00 1.40 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5616.0 BP_3 3.00 0.68 503 828203625 XP_012556000.1 250 3.3e-19 PREDICTED: RNA-directed DNA polymerase from mobile element jockey-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5622.0 BP_3 3.00 0.40 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5626.2 BP_3 14.82 0.31 2607 270005117 EFA01565.1 2059 3.0e-228 hypothetical protein TcasGA2_TC007126 [Tribolium castaneum] -- -- -- -- -- K16749 BBS7 Bardet-Biedl syndrome 7 protein http://www.genome.jp/dbget-bin/www_bget?ko:K16749 Q8K2G4 1295 4.8e-141 Bardet-Biedl syndrome 7 protein homolog OS=Mus musculus GN=Bbs7 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5629.0 BP_3 2.00 0.32 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-563.1 BP_3 6.18 0.41 1018 270004765 EFA01213.1 494 3.4e-47 hypothetical protein TcasGA2_TC010540 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 371 2.6e-34 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-5632.0 BP_3 1.00 0.38 418 385270635 AFI56574.1 153 4.9e-08 pacifastin-like serine protease inhibitor, partial [Portunus trituberculatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05375//PF00093 Pacifastin inhibitor (LCMII)//von Willebrand factor type C domain -- -- GO:0030414//GO:0005515 peptidase inhibitor activity//protein binding -- -- -- -- Cluster-5637.0 BP_3 13.80 0.48 1666 751231572 XP_011169356.1 688 1.8e-69 PREDICTED: uncharacterized protein LOC105202492 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-5649.0 BP_3 7.00 0.70 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-565.0 BP_3 16.00 1.00 1063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-566.1 BP_3 22.00 0.56 2190 861578014 KMQ82022.1 184 6.6e-11 mariner transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-567.0 BP_3 4.00 0.83 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5682.0 BP_3 3.00 0.74 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5692.0 BP_3 8.00 0.35 1403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-57.0 BP_3 19.00 3.92 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5720.0 BP_3 2.00 0.73 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5722.0 BP_3 14.18 0.97 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5727.0 BP_3 8.88 0.35 1523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5738.0 BP_3 1.00 0.36 426 861599125 KMQ83546.1 174 1.8e-10 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5740.0 BP_3 7.00 0.69 782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5744.0 BP_3 2.00 0.50 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5744.1 BP_3 4.00 0.54 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5751.0 BP_3 65.56 0.67 5006 270005459 EFA01907.1 6204 0.0e+00 hypothetical protein TcasGA2_TC007517 [Tribolium castaneum] 676475132 XM_009062126.1 77 3.57575e-29 Lottia gigantea hypothetical protein partial mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q63164 4714 0.0e+00 Dynein heavy chain 1, axonemal OS=Rattus norvegicus GN=Dnah1 PE=2 SV=2 PF03028//PF06810//PF01733 Dynein heavy chain and region D6 of dynein motor//Phage minor structural protein GP20//Nucleoside transporter GO:0007017//GO:0007018//GO:0015858//GO:0006810 microtubule-based process//microtubule-based movement//nucleoside transport//transport GO:0005337//GO:0005198//GO:0003777 nucleoside transmembrane transporter activity//structural molecule activity//microtubule motor activity GO:0016021//GO:0030286//GO:0005874 integral component of membrane//dynein complex//microtubule -- -- Cluster-5755.0 BP_3 7.00 0.50 963 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5766.0 BP_3 5.00 0.42 867 21064465 AAM29462.1 370 7.0e-33 RE36839p [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- P10394 367 6.4e-34 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-5767.1 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5775.0 BP_3 13.00 0.65 1250 751219590 XP_011162886.1 260 5.8e-20 PREDICTED: uncharacterized protein LOC105197973 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5782.0 BP_3 2.00 0.35 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5783.1 BP_3 2.00 0.53 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5797.0 BP_3 2.00 0.31 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-58.0 BP_3 7.00 0.99 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5811.0 BP_3 3.00 0.71 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5814.0 BP_3 64.00 2.35 1603 642931405 XP_008196566.1 622 7.8e-62 PREDICTED: uncharacterized protein LOC660374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 199 3.6e-14 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-582.1 BP_3 3.00 2.05 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5822.0 BP_3 5.00 0.54 740 270009975 EFA06423.1 571 3.0e-56 hypothetical protein TcasGA2_TC009302 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86LG1 147 1.8e-08 Pickpocket protein 28 OS=Drosophila melanogaster GN=ppk28 PE=1 SV=2 PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-5831.0 BP_3 2.00 0.36 563 -- -- -- -- -- 380855527 JQ004258.1 298 5.33969e-153 Portunus trituberculatus thioredoxin 2 (Trx2) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5837.0 BP_3 2.00 0.46 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5838.0 BP_3 2.00 0.39 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5846.0 BP_3 1.00 0.90 338 564298835 XP_001074464.4 329 1.5e-28 PREDICTED: transmembrane protein 258 [Rattus norvegicus]>gi|564332945|ref|XP_574622.4| PREDICTED: transmembrane protein 258 [Rattus norvegicus]>gi|149062372|gb|EDM12795.1| rCG47273, isoform CRA_b [Rattus norvegicus] 194018428 NM_014206.3 338 1.78903e-175 Homo sapiens transmembrane protein 258 (TMEM258), mRNA -- -- -- -- Q32P84 309 1.3e-27 Transmembrane protein 258 OS=Bos taurus GN=TMEM258 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4452 Predicted membrane protein Cluster-5847.0 BP_3 1.00 0.34 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5853.0 BP_3 7.00 0.31 1395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5878.0 BP_3 1.00 0.75 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5883.0 BP_3 3.00 2.25 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5885.0 BP_3 6.00 0.47 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03910 Adenovirus minor core protein PV -- -- -- -- GO:0019012 virion -- -- Cluster-5897.0 BP_3 2.00 1.50 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5899.0 BP_3 3.00 0.56 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-590.0 BP_3 12.23 1.05 853 642935788 XP_008198174.1 485 3.2e-46 PREDICTED: uncharacterized protein C4orf22 homolog [Tribolium castaneum]>gi|270013285|gb|EFA09733.1| hypothetical protein TcasGA2_TC011866 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q810M1 235 1.3e-18 Uncharacterized protein C4orf22 homolog OS=Mus musculus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5905.0 BP_3 4.00 0.94 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5910.0 BP_3 13.00 0.65 1262 270011370 EFA07818.1 522 2.4e-50 hypothetical protein TcasGA2_TC005383 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5917.0 BP_3 2.00 1.40 356 296200978 XP_002747844.1 572 1.1e-56 PREDICTED: putative 60S ribosomal protein L37a [Callithrix jacchus] 694898640 XM_516077.4 356 0 PREDICTED: Pan troglodytes ribosomal protein L37a (RPL37A), mRNA K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 P61513 485 5.5e-48 60S ribosomal protein L37a OS=Homo sapiens GN=RPL37A PE=1 SV=2 PF06689//PF01780 ClpX C4-type zinc finger//Ribosomal L37ae protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0046983//GO:0003735//GO:0008270 protein dimerization activity//structural constituent of ribosome//zinc ion binding GO:0005622//GO:0005840 intracellular//ribosome KOG0402 60S ribosomal protein L37 Cluster-5921.0 BP_3 1.00 1.22 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-593.0 BP_3 5.80 0.52 833 478254264 ENN74518.1 404 7.7e-37 hypothetical protein YQE_08842, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A5LGM7 130 1.9e-06 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF03092 Sugar (and other) transporter//Major Facilitator Superfamily//BT1 family GO:0006810//GO:0055085 transport//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-5968.0 BP_3 2.00 0.66 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5974.0 BP_3 7.00 0.40 1145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-598.0 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-599.0 BP_3 1.00 1.40 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6.0 BP_3 7.00 4.06 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-60.0 BP_3 3.00 0.46 603 -- -- -- -- -- 472455843 KC236197.1 69 1.14702e-25 Entomobrya proxima 16S ribosomal RNA gene, partial sequence; mitochondrial -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-60.1 BP_3 1.00 0.35 428 -- -- -- -- -- 472455843 KC236197.1 384 0 Entomobrya proxima 16S ribosomal RNA gene, partial sequence; mitochondrial -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6004.0 BP_3 6.00 0.50 874 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6023.0 BP_3 8.00 0.98 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6026.0 BP_3 1.00 1.58 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6028.0 BP_3 4.00 0.93 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6037.0 BP_3 5.00 0.67 652 642928460 XP_008193795.1 338 2.7e-29 PREDICTED: serine protease easter-like [Tribolium castaneum] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P00760 246 5.2e-20 Cationic trypsin OS=Bos taurus PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-604.0 BP_3 2.00 0.34 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6040.0 BP_3 3.00 0.59 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6043.0 BP_3 1.00 0.54 379 861599125 KMQ83546.1 197 3.5e-13 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6050.0 BP_3 3.41 0.33 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6052.0 BP_3 3.00 0.34 721 817054359 XP_012267140.1 754 1.7e-77 PREDICTED: acyl-CoA Delta(11) desaturase-like [Athalia rosae] 829569648 NM_001309579.1 35 1.10131e-06 Bombyx mori acyl-CoA Delta(11) desaturase-like (LOC101741176), mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 630 1.7e-64 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG1600 Fatty acid desaturase Cluster-6055.1 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-607.0 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04192 Utp21 specific WD40 associated putative domain GO:0006364 rRNA processing -- -- GO:0032040 small-subunit processome -- -- Cluster-6070.0 BP_3 2.00 0.40 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6070.1 BP_3 6.00 0.55 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6079.0 BP_3 2.00 1.08 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6100.0 BP_3 2.00 0.36 560 795012386 XP_011877837.1 318 4.8e-27 PREDICTED: uncharacterized protein LOC105567515 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6112.0 BP_3 1.00 0.33 436 21465649 1IRU 657 1.9e-66 Chain H, Crystal Structure Of The Mammalian 20s Proteasome At 2.75 A Resolution>gi|21465663|pdb|1IRU|V Chain V, Crystal Structure Of The Mammalian 20s Proteasome At 2.75 A Resolution 164697501 AK311768.1 433 0 Homo sapiens cDNA, FLJ92029, Homo sapiens proteasome (prosome, macropain) subunit, beta type, 6(PSMB6), mRNA K02738 PSMB6 20S proteasome subunit beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02738 P28072 657 7.6e-68 Proteasome subunit beta type-6 OS=Homo sapiens GN=PSMB6 PE=1 SV=4 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839//GO:0005634//GO:0005737 proteasome core complex//nucleus//cytoplasm KOG0174 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 Cluster-6114.0 BP_3 2.00 0.78 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6123.0 BP_3 3.00 0.95 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6132.0 BP_3 2.00 0.62 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6133.0 BP_3 3.00 1.09 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6134.0 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6136.0 BP_3 3.00 0.39 667 808148719 XP_012175340.1 212 1.1e-14 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105666997, partial [Bombus terrestris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098 C2H2 zinc-finger//Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-6139.0 BP_3 2.00 1.65 344 488546466 XP_004464750.1 450 1.5e-42 PREDICTED: ubiquitin-like protein 5 [Dasypus novemcinctus] 694972879 XM_512356.5 344 8.42748e-179 PREDICTED: Pan troglodytes ubiquitin-like 5 (UBL5), transcript variant X2, mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q3T0Z3 394 1.9e-37 Ubiquitin-like protein 5 OS=Bos taurus GN=UBL5 PE=3 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-614.0 BP_3 2.00 0.98 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6144.0 BP_3 1.00 0.59 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6150.0 BP_3 2.00 0.95 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6157.0 BP_3 1.00 0.35 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6163.0 BP_3 3.00 0.48 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14098 Small, acid-soluble spore protein I GO:0030436 asexual sporulation -- -- -- -- -- -- Cluster-6170.0 BP_3 3.00 0.48 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6172.0 BP_3 2.00 0.43 514 270017092 EFA13538.1 242 2.9e-18 hypothetical protein TcasGA2_TC002170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6175.0 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6180.2 BP_3 18.00 0.92 1231 91081747 XP_972750.1 1329 6.3e-144 PREDICTED: cholecystokinin receptor [Tribolium castaneum]>gi|270006463|gb|EFA02911.1| hypothetical protein TcasGA2_TC008438 [Tribolium castaneum] -- -- -- -- -- K04194 CCKAR cholecystokinin A receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04194 P70031 589 1.7e-59 Cholecystokinin receptor OS=Xenopus laevis GN=cckar PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-6183.0 BP_3 7.00 0.46 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6190.0 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-62.0 BP_3 3.00 0.42 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-620.0 BP_3 5.00 0.88 567 478251024 ENN71505.1 146 4.3e-07 hypothetical protein YQE_11798, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6200.0 BP_3 37.00 0.39 4838 665393779 NP_650019.5 157 2.0e-07 CG14692 [Drosophila melanogaster]>gi|599127689|gb|AAF54559.5| CG14692 [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02935 Cytochrome c oxidase subunit VIIc GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-6201.0 BP_3 1.00 0.33 436 478271123 ENN83588.1 291 5.1e-24 hypothetical protein YQE_00057, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6204.0 BP_3 5.00 0.91 557 189236995 XP_970755.2 357 1.4e-31 PREDICTED: uncharacterized protein LOC659345 [Tribolium castaneum]>gi|270006630|gb|EFA03078.1| hypothetical protein TcasGA2_TC010952 [Tribolium castaneum] -- -- -- -- -- K17536 CNKSR2, KSR2 connector enhancer of kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17536 -- -- -- -- -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-6226.0 BP_3 1.00 0.75 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6246.0 BP_3 2.00 0.35 571 119581587 EAW61183.1 555 1.6e-54 basigin (Ok blood group), isoform CRA_d [Homo sapiens] 530425373 XM_005259619.1 568 0 PREDICTED: Homo sapiens basigin (Ok blood group) (BSG), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6250.0 BP_3 2.00 0.34 574 675382496 KFM75393.1 418 1.3e-38 RNA-directed DNA polymerase from mobile element jockey, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6255.0 BP_3 1.00 0.34 431 821392721 XP_012388291.1 470 8.8e-45 PREDICTED: 60S ribosomal protein L35 isoform X1 [Orcinus orca] 158255579 AK291072.1 431 0 Homo sapiens cDNA FLJ76395 complete cds, highly similar to Homo sapiens ribosomal protein L35 (RPL35), mRNA K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 P42766 470 3.6e-46 60S ribosomal protein L35 OS=Homo sapiens GN=RPL35 PE=1 SV=2 PF00831 Ribosomal L29 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3436 60S ribosomal protein L35 Cluster-6267.0 BP_3 2.00 0.42 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-628.0 BP_3 16.34 4.62 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6290.0 BP_3 2.00 0.36 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6298.0 BP_3 8.00 0.63 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6306.0 BP_3 2.00 0.34 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6319.0 BP_3 11.00 0.40 1607 795019558 XP_011859621.1 420 2.1e-38 PREDICTED: uncharacterized protein LOC105557087 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6321.0 BP_3 1.00 0.39 415 189065516 BAG35355.1 635 6.2e-64 unnamed protein product [Homo sapiens] 823669623 KR709642.1 415 0 Synthetic construct Homo sapiens clone CCSBHm_00004640 CD55 (CD55) mRNA, encodes complete protein K04006 DAF, CD55 decay accelerating factor http://www.genome.jp/dbget-bin/www_bget?ko:K04006 P08174 635 2.6e-65 Complement decay-accelerating factor OS=Homo sapiens GN=CD55 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-6324.0 BP_3 7.00 0.69 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6330.0 BP_3 2.00 0.42 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6336.0 BP_3 4.00 0.40 779 828224437 XP_012562965.1 531 1.4e-51 PREDICTED: uncharacterized protein LOC105847750 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6336.1 BP_3 1.00 0.32 440 828234609 XP_012566149.1 243 1.9e-18 PREDICTED: uncharacterized protein LOC105850212, partial [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-634.0 BP_3 2.00 0.44 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6354.0 BP_3 2.00 0.57 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-636.0 BP_3 33.42 1.26 1574 270002767 EEZ99214.1 1157 7.0e-124 serine protease P12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 424 2.9e-40 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-6365.0 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-637.0 BP_3 2.00 1.33 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6391.0 BP_3 7.00 0.67 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6395.0 BP_3 3.00 0.45 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-64.0 BP_3 3.00 1.98 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6402.0 BP_3 2.00 0.36 558 642917240 XP_008191177.1 213 7.2e-15 PREDICTED: uncharacterized protein LOC103312408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-6403.0 BP_3 3.00 0.62 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6405.0 BP_3 4.01 0.55 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6410.0 BP_3 3.00 0.38 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6411.0 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6413.0 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6415.0 BP_3 2.00 0.31 603 556740225 XP_005965659.1 485 2.3e-46 PREDICTED: NADH-ubiquinone oxidoreductase chain 5-like [Pantholops hodgsonii] 597569085 KF990036.1 603 0 Prunus kansuensis chloroplast, complete genome K03883 ND5 NADH-ubiquinone oxidoreductase chain 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03883 Q9MTI4 880 1.5e-93 NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic OS=Oenothera elata subsp. hookeri GN=ndhF PE=3 SV=2 PF02508 Rnf-Nqr subunit, membrane protein -- -- -- -- GO:0016020 membrane KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-6428.0 BP_3 10.00 0.68 1003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6436.0 BP_3 5.00 0.70 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6440.0 BP_3 6.00 1.32 511 357611789 EHJ67650.1 139 2.5e-06 hypothetical protein KGM_11902 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6459.0 BP_3 17.69 1.40 899 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6473.0 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00317 Ribonucleotide reductase, all-alpha domain GO:0055114//GO:0006260//GO:0006206//GO:0006144//GO:0009186 oxidation-reduction process//DNA replication//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process GO:0004748//GO:0005524 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//ATP binding GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-6474.0 BP_3 18.17 0.67 1597 642912712 XP_008200971.1 1409 4.3e-153 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642912714|ref|XP_008200972.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 P58743 576 6.9e-58 Prestin OS=Homo sapiens GN=SLC26A5 PE=2 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-6480.0 BP_3 3.00 0.85 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6482.0 BP_3 4.00 2.22 376 6625746 AAF19378.1 637 3.3e-64 Gq/11 protein alpha subunit [Panulirus argus] 1872547 U89139.1 277 1.63428e-141 HAU89139 Homarus americanus heterotrimeric GTP-binding protein alpha subunit G-alpha-q mRNA, complete cds K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P91950 637 1.4e-65 Guanine nucleotide-binding protein G(q) subunit alpha OS=Homarus americanus PE=2 SV=1 PF00025//PF00503 ADP-ribosylation factor family//G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTP binding -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-6484.0 BP_3 1.00 0.98 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6487.2 BP_3 3.00 0.40 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-65.0 BP_3 75.00 5.60 937 642922027 XP_008192990.1 320 4.8e-27 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270007271|gb|EFA03719.1| hypothetical protein TcasGA2_TC013824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 262 1.0e-21 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-6509.0 BP_3 6.00 0.85 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6510.0 BP_3 5.00 1.02 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6515.1 BP_3 1.00 1.43 312 557782081 XP_005190656.1 163 2.5e-09 PREDICTED: piggyBac transposable element-derived protein 4-like, partial [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6518.0 BP_3 5.00 0.62 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6525.0 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6529.0 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6535.0 BP_3 1.00 0.40 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6541.1 BP_3 5.00 0.60 694 270297190 NP_001161921.1 218 2.4e-15 peritrophic matrix protein 2-C precursor [Tribolium castaneum]>gi|268309036|gb|ACY95484.1| peritrophic matrix protein 2-C [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-6562.0 BP_3 15.00 0.60 1492 861587829 KMQ82562.1 150 3.9e-07 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15184//PF03345 Mitochondrial import receptor subunit TOM6 homolog//Oligosaccharyltransferase 48 kDa subunit beta GO:0018279 protein N-linked glycosylation via asparagine -- -- GO:0005742//GO:0005789 mitochondrial outer membrane translocase complex//endoplasmic reticulum membrane -- -- Cluster-6564.0 BP_3 8.00 0.37 1322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6571.0 BP_3 7.00 0.80 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02419 PsbL protein GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-6574.0 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6584.0 BP_3 2.00 0.81 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6585.0 BP_3 3.00 0.32 742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6594.0 BP_3 2.00 0.84 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-66.0 BP_3 4.00 0.40 772 478263699 ENN82002.1 595 5.1e-59 hypothetical protein YQE_01577, partial [Dendroctonus ponderosae]>gi|546673165|gb|ERL84828.1| hypothetical protein D910_02252, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6600.0 BP_3 27.00 1.86 990 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6603.0 BP_3 3.00 0.56 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6608.0 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6618.0 BP_3 7.00 0.92 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6619.0 BP_3 8.00 3.64 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6624.0 BP_3 5.00 1.06 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6625.0 BP_3 9.00 0.71 905 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6632.0 BP_3 1.00 0.77 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6641.0 BP_3 6.41 0.53 874 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6646.0 BP_3 8.00 0.63 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6655.0 BP_3 3.00 0.37 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-666.0 BP_3 11.79 0.80 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6665.0 BP_3 4.57 0.53 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6682.0 BP_3 2.00 0.77 416 270011911 EFA08359.1 247 6.1e-19 hypothetical protein TcasGA2_TC006002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11799 impB/mucB/samB family C-terminal domain GO:0006281 DNA repair GO:0003684 damaged DNA binding -- -- -- -- Cluster-6682.1 BP_3 1.00 16.18 231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6682.3 BP_3 1.00 0.31 449 665811564 XP_008554253.1 356 1.5e-31 PREDICTED: uncharacterized protein LOC103576015 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6683.1 BP_3 12.36 1.09 839 675379677 KFM72579.1 187 1.1e-11 TSC22 domain family protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q24522 160 6.3e-10 Protein bunched, class 1/class 3/D/E isoforms OS=Drosophila melanogaster GN=bun PE=2 SV=2 PF04799//PF06156//PF01166//PF06005//PF07716 fzo-like conserved region//Protein of unknown function (DUF972)//TSC-22/dip/bun family//Protein of unknown function (DUF904)//Basic region leucine zipper GO:0006260//GO:0006355//GO:0008053//GO:0043093//GO:0000917 DNA replication//regulation of transcription, DNA-templated//mitochondrial fusion//FtsZ-dependent cytokinesis//barrier septum assembly GO:0003924//GO:0043565//GO:0003700 GTPase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667//GO:0005741//GO:0005737 integral component of membrane//transcription factor complex//mitochondrial outer membrane//cytoplasm KOG4797 Transcriptional regulator Cluster-6685.0 BP_3 2.00 0.45 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6687.0 BP_3 2.00 0.81 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05410 Porcine arterivirus-type cysteine proteinase alpha GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-669.0 BP_3 5.00 0.64 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-67.0 BP_3 5.00 0.98 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6703.0 BP_3 4.00 0.37 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6705.0 BP_3 2.00 1.15 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6705.1 BP_3 5.00 0.85 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6706.0 BP_3 22.00 0.64 1936 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6706.1 BP_3 1.00 0.53 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6706.2 BP_3 10.23 0.56 1167 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6709.0 BP_3 4.00 1.26 444 213511390 NP_001134118.1 275 3.7e-22 Plasma membrane proteolipid 3 precursor [Salmo salar]>gi|209730844|gb|ACI66291.1| Plasma membrane proteolipid 3 [Salmo salar] 697066746 XM_009650265.1 441 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- P0CS18 157 7.4e-10 Plasma membrane proteolipid 3 OS=Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) GN=PMP3 PE=3 SV=1 PF01679 Proteolipid membrane potential modulator -- -- -- -- GO:0016021 integral component of membrane KOG1773 Stress responsive protein Cluster-6710.0 BP_3 3.00 0.60 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6714.0 BP_3 8.00 0.74 810 675866222 XP_009018671.1 325 1.1e-27 hypothetical protein HELRODRAFT_173812 [Helobdella robusta]>gi|555699745|gb|ESO02978.1| hypothetical protein HELRODRAFT_173812 [Helobdella robusta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6754.0 BP_3 5.00 1.23 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6765.0 BP_3 7.00 0.52 946 642920523 XP_008192386.1 997 1.5e-105 PREDICTED: cytoplasmic dynein 2 heavy chain 1 [Tribolium castaneum] -- -- -- -- -- K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q45VK7 489 5.0e-48 Cytoplasmic dynein 2 heavy chain 1 OS=Mus musculus GN=Dync2h1 PE=1 SV=1 PF01637//PF07726 Archaeal ATPase//ATPase family associated with various cellular activities (AAA) -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- KOG3595 Dyneins, heavy chain Cluster-6765.3 BP_3 42.00 0.55 3961 270005976 EFA02424.1 3990 0.0e+00 hypothetical protein TcasGA2_TC008109 [Tribolium castaneum] -- -- -- -- -- K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q27802 2615 6.3e-294 Cytoplasmic dynein 2 heavy chain 1 OS=Tripneustes gratilla GN=DYH1B PE=2 SV=2 PF09728//PF06009//PF09085//PF13851//PF03028 Myosin-like coiled-coil protein//Laminin Domain II//Adhesion molecule, immunoglobulin-like//Growth-arrest specific micro-tubule binding//Dynein heavy chain and region D6 of dynein motor GO:0007018//GO:0048870//GO:0007155//GO:0007017 microtubule-based movement//cell motility//cell adhesion//microtubule-based process GO:0019905//GO:0003777 syntaxin binding//microtubule motor activity GO:0031514//GO:0030286//GO:0005874//GO:0016020 motile cilium//dynein complex//microtubule//membrane KOG3595 Dyneins, heavy chain Cluster-677.0 BP_3 28.00 0.74 2120 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6780.0 BP_3 1.00 3.93 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6782.0 BP_3 4.00 3.98 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6785.0 BP_3 3.00 0.33 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6788.0 BP_3 11.00 1.03 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6788.1 BP_3 2.00 0.33 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6794.0 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6800.0 BP_3 4.00 0.40 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6803.0 BP_3 2.00 0.41 528 -- -- -- -- -- 696221409 NG_041768.1 528 0 Homo sapiens CD24 molecule (CD24), RefSeqGene on chromosome 6 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6808.0 BP_3 5.00 0.85 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6826.0 BP_3 14.59 0.87 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6831.0 BP_3 2.00 0.53 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6838.0 BP_3 2.00 0.69 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6845.0 BP_3 4.00 0.36 820 148680564 EDL12511.1 646 6.6e-65 gamma-aminobutyric acid receptor associated protein, isoform CRA_a [Mus musculus] 6005763 NM_007278.1 820 0 Homo sapiens GABA(A) receptor-associated protein (GABARAP), mRNA >gnl|BL_ORD_ID|875827 Homo sapiens ganglioside expression factor 2 homolog mRNA, complete cds K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 Q9DCD6 614 1.4e-62 Gamma-aminobutyric acid receptor-associated protein OS=Mus musculus GN=Gabarap PE=1 SV=2 PF04110 Ubiquitin-like autophagy protein Apg12 GO:0000045 autophagosome assembly -- -- GO:0005737 cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-6847.0 BP_3 10.10 1.69 579 270017034 EFA13480.1 136 6.4e-06 hypothetical protein TcasGA2_TC002031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6862.0 BP_3 5.00 0.37 946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6867.0 BP_3 1.00 0.39 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6873.0 BP_3 2.00 0.87 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6875.0 BP_3 19.00 0.56 1930 270011462 EFA07910.1 2740 2.4e-307 hypothetical protein TcasGA2_TC005485 [Tribolium castaneum] 768435726 XM_011561022.1 252 7.12512e-127 PREDICTED: Plutella xylostella dynein heavy chain 3, axonemal-like (LOC105389828), partial mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8TD57 2101 1.2e-234 Dynein heavy chain 3, axonemal OS=Homo sapiens GN=DNAH3 PE=2 SV=1 PF08653//PF02388 DASH complex subunit Dam1//FemAB family GO:0009252//GO:0008608 peptidoglycan biosynthetic process//attachment of spindle microtubules to kinetochore GO:0016755 transferase activity, transferring amino-acyl groups GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-6882.0 BP_3 1.00 0.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6911.0 BP_3 2.00 0.40 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6913.0 BP_3 4.00 0.39 788 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-6925.1 BP_3 1.00 0.38 418 642921121 XP_008192696.1 478 1.0e-45 PREDICTED: H2.0-like homeobox protein [Tribolium castaneum]>gi|270006199|gb|EFA02647.1| hypothetical protein TcasGA2_TC008368 [Tribolium castaneum] 768941240 XM_011612188.1 62 6.04414e-22 PREDICTED: Takifugu rubripes H2.0-like homeobox (hlx), transcript variant X2, mRNA K09339 HLX1 homeobox protein HLX1 http://www.genome.jp/dbget-bin/www_bget?ko:K09339 Q14774 324 3.0e-29 H2.0-like homeobox protein OS=Homo sapiens GN=HLX PE=1 SV=3 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0000976//GO:0003700//GO:0003677 transcription regulatory region sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0491 Transcription factor BSH, contains HOX domain Cluster-695.0 BP_3 2.00 0.59 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6958.0 BP_3 3.00 0.50 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6966.0 BP_3 8.00 1.66 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02023 SCAN domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-6978.0 BP_3 2.00 0.62 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6983.0 BP_3 3.00 0.34 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6991.0 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6998.0 BP_3 2.00 0.94 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7.0 BP_3 7.00 1.87 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-70.0 BP_3 3.00 0.80 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7003.0 BP_3 4.00 0.52 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7005.0 BP_3 2.00 0.56 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06072 Alphaherpesvirus tegument protein US9 -- -- -- -- GO:0019033 viral tegument -- -- Cluster-7010.0 BP_3 2.00 1.68 343 803207736 XP_011964399.1 432 1.8e-40 PREDICTED: 40S ribosomal protein S21 isoform X3 [Ovis aries musimon] 115553416 AK236619.1 343 3.02131e-178 Sus scrofa mRNA, clone:OVRM10208G12, expressed in ovary K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 P63221 424 6.2e-41 40S ribosomal protein S21 OS=Sus scrofa GN=RPS21 PE=1 SV=1 PF01249 Ribosomal protein S21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3486 40S ribosomal protein S21 Cluster-7019.1 BP_3 8.00 0.50 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-702.0 BP_3 2.00 1.52 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7020.0 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7021.0 BP_3 1.00 0.47 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7021.1 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7026.0 BP_3 3.00 0.66 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7028.1 BP_3 2.00 0.36 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7034.0 BP_3 3.00 0.55 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7035.0 BP_3 3.00 0.60 534 102939 244 1.8e-18 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 198 1.6e-14 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7042.0 BP_3 10.00 0.95 798 642928332 XP_008195538.1 857 2.2e-89 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 P54316 324 5.7e-29 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 PF01764//PF07819//PF07859//PF00975 Lipase (class 3)//PGAP1-like protein//alpha/beta hydrolase fold//Thioesterase domain GO:0009058//GO:0008152//GO:0006505//GO:0006886//GO:0006629 biosynthetic process//metabolic process//GPI anchor metabolic process//intracellular protein transport//lipid metabolic process GO:0016787//GO:0016788 hydrolase activity//hydrolase activity, acting on ester bonds GO:0005576 extracellular region -- -- Cluster-7043.0 BP_3 4.00 0.68 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7049.0 BP_3 4.00 0.87 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7068.0 BP_3 14.00 0.45 1775 642939079 XP_008200213.1 1158 6.1e-124 PREDICTED: zinc metalloproteinase nas-4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55113 310 5.4e-27 Zinc metalloproteinase nas-7 OS=Caenorhabditis elegans GN=nas-7 PE=2 SV=2 PF01400 Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-7072.0 BP_3 4.00 0.41 759 260832470 XP_002611180.1 293 5.2e-24 hypothetical protein BRAFLDRAFT_88421 [Branchiostoma floridae]>gi|229296551|gb|EEN67190.1| hypothetical protein BRAFLDRAFT_88421 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q8R5M3 233 1.9e-18 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-7078.0 BP_3 1.00 0.74 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7082.0 BP_3 2.00 0.83 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7091.0 BP_3 1.00 1.06 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7093.0 BP_3 1.00 0.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-711.0 BP_3 3.00 1.63 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7113.0 BP_3 5.00 0.32 1047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7136.0 BP_3 2.00 0.36 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7150.0 BP_3 2.00 0.33 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7151.0 BP_3 2.00 0.33 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7160.0 BP_3 1.00 0.48 390 685615894 XP_009195712.1 578 2.4e-57 PREDICTED: 60S ribosomal protein L36a-like [Papio anubis] 453040294 NM_001001.4 339 5.82224e-176 Homo sapiens ribosomal protein L36a-like (RPL36AL), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 P83882 563 5.4e-57 60S ribosomal protein L36a OS=Mus musculus GN=Rpl36a PE=1 SV=2 PF00935 Ribosomal protein L44 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3464 60S ribosomal protein L44 Cluster-7162.0 BP_3 7.00 1.08 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11616 WD repeat binding protein EZH2 GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0018024 histone-lysine N-methyltransferase activity -- -- -- -- Cluster-7166.0 BP_3 1.00 1.37 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7171.0 BP_3 6.00 1.31 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7171.1 BP_3 4.14 3.92 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7178.0 BP_3 2.00 0.52 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7192.0 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7213.0 BP_3 2.00 0.51 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-723.0 BP_3 18.00 2.60 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7245.0 BP_3 2.00 0.31 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7250.0 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7257.0 BP_3 2.00 0.87 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7258.1 BP_3 6.00 0.35 1128 196020247 XP_002119097.1 147 6.6e-07 hypothetical protein TRIADDRAFT_35144 [Trichoplax adhaerens]>gi|190576971|gb|EDV18417.1| hypothetical protein TRIADDRAFT_35144 [Trichoplax adhaerens] 761231605 KM881639.1 1125 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P0C474 352 4.6e-32 30S ribosomal protein S16, chloroplastic OS=Oryza sativa subsp. indica GN=rps16 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7264.1 BP_3 1.00 1.22 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7265.0 BP_3 2.00 0.45 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7281.0 BP_3 3.00 0.32 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7283.0 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7290.0 BP_3 1.00 0.33 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-731.0 BP_3 7.00 0.93 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7311.0 BP_3 1.00 2.02 296 780661482 XP_011692937.1 182 1.5e-11 PREDICTED: protein NipSnap [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- Q9VXK0 175 4.0e-12 Protein NipSnap OS=Drosophila melanogaster GN=Nipsnap PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2883 NIPSNAP1 protein Cluster-7315.0 BP_3 4.00 0.71 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-7320.0 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7325.0 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7340.0 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7343.0 BP_3 5.00 0.50 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7347.0 BP_3 2.00 0.91 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7350.0 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7355.0 BP_3 2.00 0.31 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10186//PF02601//PF17082//PF08702//PF01496//PF01401//PF05279 Vacuolar sorting 38 and autophagy-related subunit 14//Exonuclease VII, large subunit//Spindle Pole Component 29//Fibrinogen alpha/beta chain family//V-type ATPase 116kDa subunit family//Angiotensin-converting enzyme//Aspartyl beta-hydroxylase N-terminal region GO:0051258//GO:0007165//GO:0010508//GO:0015992//GO:0015991//GO:0030474//GO:0006308//GO:0006508//GO:0030168 protein polymerization//signal transduction//positive regulation of autophagy//proton transport//ATP hydrolysis coupled proton transport//spindle pole body duplication//DNA catabolic process//proteolysis//platelet activation GO:0008241//GO:0005102//GO:0015078//GO:0005200//GO:0008855//GO:0008237//GO:0030674 peptidyl-dipeptidase activity//receptor binding//hydrogen ion transmembrane transporter activity//structural constituent of cytoskeleton//exodeoxyribonuclease VII activity//metallopeptidase activity//protein binding, bridging GO:0005577//GO:0005823//GO:0009318//GO:0005856//GO:0033179//GO:0016020 fibrinogen complex//central plaque of spindle pole body//exodeoxyribonuclease VII complex//cytoskeleton//proton-transporting V-type ATPase, V0 domain//membrane -- -- Cluster-7387.0 BP_3 3.00 0.56 548 16903179 AAK61417.1 211 1.2e-14 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7397.0 BP_3 1.00 0.70 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7398.0 BP_3 3.00 0.49 586 668461876 KFB49397.1 766 5.7e-79 hypothetical protein ZHAS_00017497 [Anopheles sinensis] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 Q9JID6 654 2.3e-67 Long-chain-fatty-acid--CoA ligase 1 OS=Cavia porcellus GN=ACSL1 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1256 Long-chain acyl-CoA synthetases (AMP-forming) Cluster-74.0 BP_3 5.00 2.34 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7400.0 BP_3 7.00 0.48 997 -- -- -- -- -- 642918993 XM_008193468.1 39 9.22557e-09 PREDICTED: Tribolium castaneum tyrosine-protein kinase Btk29A (LOC663266), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-741.0 BP_3 3.32 1.49 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7414.0 BP_3 5.00 1.41 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7420.0 BP_3 12.22 0.46 1578 478251276 ENN71747.1 506 2.2e-48 hypothetical protein YQE_11567, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5U239 190 3.9e-13 Transmembrane protein 145 OS=Xenopus laevis GN=tmem145 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7424.0 BP_3 1.00 0.53 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-743.0 BP_3 2.00 2.69 315 759032791 XP_011331665.1 152 4.9e-08 PREDICTED: uncharacterized protein LOC105275124 isoform X2 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7433.0 BP_3 3.00 0.37 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7436.0 BP_3 1.00 0.56 375 545214224 XP_003364867.2 296 1.1e-24 PREDICTED: mitochondrial import receptor subunit TOM7 homolog isoform X1 [Equus caballus]>gi|664704339|ref|XP_008533810.1| PREDICTED: mitochondrial import receptor subunit TOM7 homolog [Equus przewalskii] 409971398 NM_019059.3 375 0 Homo sapiens translocase of outer mitochondrial membrane 7 homolog (yeast) (TOMM7), mRNA K17771 TOM7 mitochondrial import receptor subunit TOM7 http://www.genome.jp/dbget-bin/www_bget?ko:K17771 Q9P0U1 288 4.0e-25 Mitochondrial import receptor subunit TOM7 homolog OS=Homo sapiens GN=TOMM7 PE=1 SV=1 PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-7440.0 BP_3 1.00 0.64 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7457.0 BP_3 4.00 0.61 610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7457.1 BP_3 3.00 0.85 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-748.0 BP_3 3.00 0.39 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7485.0 BP_3 7.00 0.40 1134 642917560 XP_008191257.1 189 8.9e-12 PREDICTED: F-box only protein 25 [Tribolium castaneum] 642917559 XM_008193035.1 71 1.71418e-26 PREDICTED: Tribolium castaneum F-box only protein 25 (LOC659307), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7487.0 BP_3 5.00 0.35 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03521 Kv2 voltage-gated K+ channel GO:0006813 potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0008076 voltage-gated potassium channel complex -- -- Cluster-7494.0 BP_3 3.00 0.39 660 642911659 XP_008200691.1 893 1.2e-93 PREDICTED: protein lin-31 isoform X1 [Tribolium castaneum]>gi|270014709|gb|EFA11157.1| hypothetical protein TcasGA2_TC004761 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P32028 279 7.9e-24 Fork head domain-containing protein FD4 OS=Drosophila melanogaster GN=fd96Ca PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-7496.0 BP_3 2.00 0.35 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7497.0 BP_3 6.00 0.51 854 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7518.0 BP_3 3.00 0.35 707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7520.0 BP_3 2.00 0.32 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7521.0 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7530.0 BP_3 3.00 0.43 630 478250813 ENN71305.1 284 4.8e-23 hypothetical protein YQE_12230, partial [Dendroctonus ponderosae]>gi|546679731|gb|ERL90146.1| hypothetical protein D910_07500, partial [Dendroctonus ponderosae] -- -- -- -- -- K03440 ASICN amiloride-sensitive sodium channel, other http://www.genome.jp/dbget-bin/www_bget?ko:K03440 -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-754.0 BP_3 5.00 0.49 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7542.0 BP_3 2.00 0.99 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7552.0 BP_3 24.26 0.78 1788 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7557.0 BP_3 2.00 1.06 380 759069159 XP_011344114.1 147 2.2e-07 PREDICTED: uncharacterized protein LOC105283217 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7563.0 BP_3 5.00 1.84 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7563.1 BP_3 3.00 0.43 625 662219149 XP_008483641.1 556 1.4e-54 PREDICTED: myb-like protein P [Diaphorina citri]>gi|662220839|ref|XP_008484576.1| PREDICTED: myb-like protein P [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q967S7 138 1.7e-07 Retrovirus-related Gag polyprotein from transposon HMS-Beagle OS=Drosophila melanogaster GN=gag PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7567.0 BP_3 1.00 0.79 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7588.0 BP_3 17.74 0.47 2107 270004962 EFA01410.1 202 5.2e-13 odorant receptor 226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-76.0 BP_3 8.00 5.27 361 91088161 XP_976346.1 162 3.8e-09 PREDICTED: uncharacterized protein LOC660496 [Tribolium castaneum]>gi|270012122|gb|EFA08570.1| hypothetical protein TcasGA2_TC006225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7600.0 BP_3 12.00 0.37 1854 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7611.0 BP_3 1.00 0.90 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7634.0 BP_3 2.00 0.58 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7636.0 BP_3 5.00 0.78 601 675377988 KFM70890.1 277 3.0e-22 hypothetical protein X975_01393, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-7641.0 BP_3 10.00 0.58 1116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7643.1 BP_3 6.00 0.37 1064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7646.0 BP_3 3.00 0.55 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-765.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7652.0 BP_3 3.00 0.67 506 861619174 KMQ86966.1 203 9.5e-14 fatty acid synthase, partial [Lasius niger] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 196 2.5e-14 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-7657.0 BP_3 11.00 0.42 1547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05563 Salmonella plasmid virulence protein SpvD GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-7661.0 BP_3 11.36 0.66 1120 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7662.0 BP_3 29.15 4.96 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7670.0 BP_3 2.00 0.33 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7679.1 BP_3 2.00 0.70 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7682.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7683.0 BP_3 3.00 1.91 364 642920523 XP_008192386.1 269 1.5e-21 PREDICTED: cytoplasmic dynein 2 heavy chain 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7689.0 BP_3 3.00 0.39 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7692.0 BP_3 2.00 5.91 281 -- -- -- -- -- 312274280 HM363334.1 278 3.28539e-142 Uncultured bacterium clone marine_ozone_A9 16S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-77.0 BP_3 51.00 5.60 731 642922023 XP_967255.3 386 8.3e-35 PREDICTED: uncharacterized protein LOC655601 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 300 3.2e-26 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-7703.0 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7706.0 BP_3 1.00 0.65 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7708.1 BP_3 2.00 0.56 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7714.0 BP_3 1.00 0.70 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7716.0 BP_3 2.00 0.33 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7735.0 BP_3 2.00 0.50 486 588294489 AHK23026.1 212 8.2e-15 beta-1,3-glucan-binding protein precursor [Astacus astacus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04648 Yeast mating factor alpha hormone GO:0019953//GO:0007165 sexual reproduction//signal transduction GO:0000772 mating pheromone activity GO:0005576 extracellular region -- -- Cluster-7746.0 BP_3 3.00 0.56 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7753.0 BP_3 1.00 0.86 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7762.0 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7762.2 BP_3 8.00 0.53 1025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7766.0 BP_3 4.00 0.35 835 270015878 EFA12326.1 559 8.2e-55 hypothetical protein TcasGA2_TC005154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 220 6.9e-17 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-777.0 BP_3 10.00 0.79 901 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7776.0 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7789.0 BP_3 10.00 0.39 1536 113206044 NP_001038094.1 1387 1.5e-150 chitinase 8 precursor [Tribolium castaneum]>gi|109895308|gb|ABG47446.1| chitinase 8 [Tribolium castaneum]>gi|270010245|gb|EFA06693.1| hypothetical protein TcasGA2_TC009624 [Tribolium castaneum] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q91XA9 820 3.4e-86 Acidic mammalian chitinase OS=Mus musculus GN=Chia PE=1 SV=2 PF00704//PF01607//PF03549//PF02135 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain//Translocated intimin receptor (Tir) intimin-binding domain//TAZ zinc finger GO:0071704//GO:0005975//GO:0006355//GO:0042967//GO:0006030 organic substance metabolic process//carbohydrate metabolic process//regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process//chitin metabolic process GO:0008061//GO:0005515//GO:0004402//GO:0008270//GO:0003712//GO:0004553//GO:0016798 chitin binding//protein binding//histone acetyltransferase activity//zinc ion binding//transcription cofactor activity//hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity, acting on glycosyl bonds GO:0000123//GO:0005576//GO:0005667//GO:0005634 histone acetyltransferase complex//extracellular region//transcription factor complex//nucleus -- -- Cluster-7790.0 BP_3 8.00 1.05 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-78.0 BP_3 3.00 0.36 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7804.0 BP_3 3.00 0.37 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7808.0 BP_3 2.00 0.63 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-782.0 BP_3 3.00 2.28 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03526 Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-7832.0 BP_3 1.00 0.32 441 556756359 XP_005973529.1 354 2.5e-31 PREDICTED: 30S ribosomal protein S11, chloroplastic-like [Pantholops hodgsonii] 761231856 KM881642.1 441 0 Oryza longistaminata isolate 81953 chloroplast, complete genome K02948 RP-S11, MRPS11, rpsK small subunit ribosomal protein S11 http://www.genome.jp/dbget-bin/www_bget?ko:K02948 P0C462 721 2.9e-75 30S ribosomal protein S11, chloroplastic OS=Oryza sativa GN=rps11 PE=3 SV=1 PF00411 Ribosomal protein S11 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-784.0 BP_3 35.43 2.94 873 642913278 XP_008201467.1 139 4.3e-06 PREDICTED: insulin-like growth factor I, adult form isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03488//PF00049 Nematode insulin-related peptide beta type//Insulin/IGF/Relaxin family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-7840.0 BP_3 2.00 9.14 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7846.0 BP_3 2.00 0.31 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7848.0 BP_3 3.00 1.18 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7869.0 BP_3 2.00 6.41 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7871.0 BP_3 15.50 0.61 1512 189239126 XP_971165.2 247 2.2e-18 PREDICTED: TRAF3-interacting protein 1 [Tribolium castaneum]>gi|270009803|gb|EFA06251.1| hypothetical protein TcasGA2_TC009109 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDR0 156 3.3e-09 TRAF3-interacting protein 1 OS=Homo sapiens GN=TRAF3IP1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7890.0 BP_3 1.00 1.37 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-79.0 BP_3 7.00 0.40 1131 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7904.0 BP_3 19.57 0.73 1580 546674358 ERL85745.1 493 7.0e-47 hypothetical protein D910_03160 [Dendroctonus ponderosae] -- -- -- -- -- K09622 KLK14 kallikrein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09622 Q00871 433 2.6e-41 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-7919.0 BP_3 2.00 1.52 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7927.0 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7930.0 BP_3 8.00 0.73 822 675368932 KFM61834.1 273 1.2e-21 RNA-directed DNA polymerase from mobile element jockey, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7946.0 BP_3 8.00 0.95 698 270012930 EFA09378.1 180 6.1e-11 hypothetical protein TcasGA2_TC001939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7948.0 BP_3 5.00 0.83 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7949.0 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-795.0 BP_3 3.00 0.33 727 642913370 XP_008195441.1 150 1.9e-07 PREDICTED: uncharacterized protein LOC103313587 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7978.0 BP_3 2.00 0.40 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7979.1 BP_3 1.00 0.73 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7980.0 BP_3 2.00 0.31 601 528768998 EPY88657.1 850 1.1e-88 T-complex protein 1 subunit gamma [Camelus ferus] 426332072 XM_004026968.1 601 0 PREDICTED: Gorilla gorilla gorilla chaperonin containing TCP1, subunit 3 (gamma) (CCT3), mRNA K09495 CCT3, TRIC5 T-complex protein 1 subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K09495 Q3T0K2 849 5.7e-90 T-complex protein 1 subunit gamma OS=Bos taurus GN=CCT3 PE=1 SV=1 PF08026//PF00118 Bee antimicrobial peptide//TCP-1/cpn60 chaperonin family GO:0042381 hemolymph coagulation GO:0005524 ATP binding GO:0005576 extracellular region KOG0364 Chaperonin complex component, TCP-1 gamma subunit (CCT3) Cluster-7997.3 BP_3 1.00 2.28 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8.0 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-80.0 BP_3 6.00 1.12 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8001.0 BP_3 1.00 0.48 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-801.0 BP_3 3.00 1.65 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00165 Bacterial regulatory helix-turn-helix proteins, AraC family GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8010.0 BP_3 6.00 0.68 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8016.1 BP_3 10.00 0.72 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8016.4 BP_3 11.00 0.43 1521 478267983 ENN83126.1 1224 1.2e-131 hypothetical protein YQE_00516, partial [Dendroctonus ponderosae]>gi|478268197|gb|ENN83167.1| hypothetical protein YQE_00469, partial [Dendroctonus ponderosae]>gi|546676729|gb|ERL87685.1| hypothetical protein D910_05075 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q17QK3 965 5.1e-103 Carboxypeptidase Q OS=Bos taurus GN=CPQ PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8022.2 BP_3 3.00 0.92 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8025.0 BP_3 2.00 0.40 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8026.0 BP_3 3.00 0.72 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-803.0 BP_3 9.11 1.00 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8050.0 BP_3 1.00 0.51 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8055.1 BP_3 2.00 0.64 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8068.0 BP_3 7.00 0.55 908 732554603 AIZ72682.1 450 3.9e-42 c-type lysozyme 4 [Harmonia axyridis] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 Q17005 284 2.8e-24 Lysozyme c-1 OS=Anopheles gambiae GN=AGAP007347 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-807.0 BP_3 3.00 0.42 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-807.1 BP_3 3.00 2.45 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8070.0 BP_3 1.00 0.50 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8091.0 BP_3 10.25 0.40 1539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8095.1 BP_3 2.00 0.54 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8098.1 BP_3 6.00 0.40 1006 642933000 XP_008197222.1 1242 6.3e-134 PREDICTED: dynein heavy chain 3, axonemal [Tribolium castaneum] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8BW94 436 7.5e-42 Dynein heavy chain 3, axonemal OS=Mus musculus GN=Dnah3 PE=2 SV=2 PF02966 Mitosis protein DIM1 GO:0000398 mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex -- -- Cluster-81.0 BP_3 67.00 15.06 506 642922027 XP_008192990.1 279 1.5e-22 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270007271|gb|EFA03719.1| hypothetical protein TcasGA2_TC013824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 240 2.0e-19 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-810.0 BP_3 3.00 0.84 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8102.0 BP_3 2.00 0.42 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10288 Cytoplasmic tRNA 2-thiolation protein 2 GO:0002098//GO:0034227 tRNA wobble uridine modification//tRNA thio-modification GO:0000049 tRNA binding -- -- -- -- Cluster-8107.0 BP_3 1.00 0.51 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8112.0 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8115.0 BP_3 3.00 0.59 535 -- -- -- -- -- 84682159 DQ351941.1 525 0 Verticillium dahliae mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8138.0 BP_3 6.00 0.35 1123 270011249 EFA07697.1 488 1.9e-46 hypothetical protein TcasGA2_TC002173 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8141.0 BP_3 2.00 1.37 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-815.0 BP_3 2.00 0.39 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8154.0 BP_3 3.00 0.68 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8156.0 BP_3 2.00 1.23 367 328700389 XP_003241240.1 197 3.4e-13 PREDICTED: uncharacterized protein LOC100574845 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8161.0 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8164.0 BP_3 14.00 1.10 906 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8165.0 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8168.0 BP_3 2.00 0.32 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-817.0 BP_3 4.00 0.82 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-817.1 BP_3 2.00 0.66 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8171.0 BP_3 1.00 0.71 355 270004778 EFA01226.1 188 3.6e-12 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 151 2.9e-09 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8180.0 BP_3 1.00 0.36 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8183.0 BP_3 2.00 0.39 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8187.0 BP_3 2.00 0.37 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8201.0 BP_3 2.00 0.67 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8208.0 BP_3 2.00 0.71 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8208.1 BP_3 5.00 0.36 965 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8213.0 BP_3 3.00 0.42 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8217.1 BP_3 29.74 0.45 3453 755956953 XP_011303604.1 3860 0.0e+00 PREDICTED: glutamate receptor ionotropic, kainate 2 isoform X1 [Fopius arisanus] 817201409 XM_012421026.1 423 0 PREDICTED: Orussus abietinus glutamate receptor ionotropic, kainate 2-like (LOC105697583), mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1445 2.6e-158 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF00060//PF10613//PF01726 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//LexA DNA binding domain GO:0006811//GO:0006508//GO:0007268//GO:0007165 ion transport//proteolysis//synaptic transmission//signal transduction GO:0004252//GO:0005234//GO:0004970 serine-type endopeptidase activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8217.2 BP_3 25.07 0.37 3571 817201410 XP_012276449.1 1876 6.8e-207 PREDICTED: glutamate receptor ionotropic, kainate 2-like [Orussus abietinus] 817201409 XM_012421026.1 254 1.02717e-127 PREDICTED: Orussus abietinus glutamate receptor ionotropic, kainate 2-like (LOC105697583), mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 1306 3.5e-142 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8237.0 BP_3 2.00 0.44 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8248.0 BP_3 2.00 0.69 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8255.1 BP_3 1.00 0.49 388 297297830 XP_002805090.1 138 2.5e-06 PREDICTED: hypothetical protein LOC100427867 [Macaca mulatta] 767958029 XM_011518911.1 388 0 PREDICTED: Homo sapiens SET nuclear proto-oncogene (SET), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8260.0 BP_3 1.00 0.41 408 767880050 XP_011513308.1 392 9.2e-36 PREDICTED: histone-lysine N-methyltransferase 2C-like [Homo sapiens] 392996990 AC246784.2 405 0 Homo sapiens BAC clone CH17-70N6 from chromosome 1, complete sequence K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8BRH4 360 2.0e-33 Histone-lysine N-methyltransferase 2C OS=Mus musculus GN=Kmt2c PE=1 SV=2 PF07649//PF00628//PF00130 C1-like domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0047134 protein binding//protein-disulfide reductase activity -- -- -- -- Cluster-8266.0 BP_3 11.00 1.75 594 642915036 XP_008190384.1 295 2.4e-24 PREDICTED: eclosion hormone-like isoform X2 [Tribolium castaneum]>gi|270002727|gb|EEZ99174.1| eclosion hormone-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25331 150 6.4e-09 Eclosion hormone OS=Bombyx mori PE=1 SV=2 PF04736 Eclosion hormone GO:0018990//GO:0007218 ecdysis, chitin-based cuticle//neuropeptide signaling pathway GO:0008255 ecdysis-triggering hormone activity -- -- -- -- Cluster-8281.0 BP_3 6.00 0.43 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8284.0 BP_3 1.00 0.80 346 375073649 AFA34383.1 521 8.7e-51 ribosomal protein L37 [Ostrea edulis] 675710638 XM_003810973.2 346 6.55674e-180 PREDICTED: Pan paniscus ribosomal protein L37 (RPL37), mRNA K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 P79244 489 1.8e-48 60S ribosomal protein L37 OS=Bos taurus GN=RPL37 PE=3 SV=4 PF01155//PF04060//PF01907 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Putative Fe-S cluster//Ribosomal protein L37e GO:0042254//GO:0006464//GO:0006412 ribosome biogenesis//cellular protein modification process//translation GO:0051536//GO:0003735//GO:0016151 iron-sulfur cluster binding//structural constituent of ribosome//nickel cation binding GO:0005840//GO:0005622 ribosome//intracellular KOG3475 60S ribosomal protein L37 Cluster-8293.0 BP_3 2.00 0.32 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8297.0 BP_3 1.00 1.30 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-83.0 BP_3 9.00 2.03 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8303.0 BP_3 2.00 0.35 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.0 BP_3 9.00 0.41 1358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1 BP_3 6.00 0.37 1078 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10 BP_3 20.32 0.52 2166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10000 BP_3 2.39 0.94 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10001 BP_3 9.68 0.62 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00895 ATP synthase protein 8 GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.10004 BP_3 23.00 0.41 2969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.1001 BP_3 27.01 0.41 3442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10014 BP_3 127.08 1.87 3571 546685251 ERL94778.1 1443 1.1e-156 hypothetical protein D910_12052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2Q2 261 5.2e-21 FERM domain-containing protein 4A OS=Homo sapiens GN=FRMD4A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10018 BP_3 6.33 0.44 992 546675072 ERL86327.1 545 4.1e-53 hypothetical protein D910_03735 [Dendroctonus ponderosae] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 418 9.0e-40 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.10019 BP_3 23.00 4.63 531 795023802 XP_011861061.1 513 1.1e-49 PREDICTED: 60S ribosomal protein L27a [Vollenhovia emeryi] 172051103 EU574820.1 116 7.47582e-52 Ornithodoros coriaceus clone OC-240 60s ribosomal protein L15/L27 mRNA, complete cds K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 P18445 475 1.2e-46 60S ribosomal protein L27a OS=Rattus norvegicus GN=Rpl27a PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1742 60s ribosomal protein L15/L27 Cluster-8309.10024 BP_3 2.24 0.43 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10026 BP_3 2.00 0.66 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1003 BP_3 3.00 0.40 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10032 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10037 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10038 BP_3 4706.57 708.22 612 270009685 EFA06133.1 261 2.2e-20 hypothetical protein TcasGA2_TC008976 [Tribolium castaneum] -- -- -- -- -- K08117 APLP2 amyloid beta (A4) precursor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08117 Q7TQN3 177 4.9e-12 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 OS=Mus musculus GN=Wfikkn2 PE=1 SV=2 PF00014//PF00892 Kunitz/Bovine pancreatic trypsin inhibitor domain//EamA-like transporter family -- -- GO:0004867 serine-type endopeptidase inhibitor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.10039 BP_3 262.22 4.92 2860 270009685 EFA06133.1 254 6.5e-19 hypothetical protein TcasGA2_TC008976 [Tribolium castaneum] -- -- -- -- -- K08117 APLP2 amyloid beta (A4) precursor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08117 Q06481 172 8.7e-11 Amyloid-like protein 2 OS=Homo sapiens GN=APLP2 PE=1 SV=2 PF00892//PF00014 EamA-like transporter family//Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.10040 BP_3 20.21 0.52 2165 270009685 EFA06133.1 255 3.8e-19 hypothetical protein TcasGA2_TC008976 [Tribolium castaneum] -- -- -- -- -- K08117 APLP2 amyloid beta (A4) precursor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08117 Q06481 173 5.0e-11 Amyloid-like protein 2 OS=Homo sapiens GN=APLP2 PE=1 SV=2 PF00014//PF00892 Kunitz/Bovine pancreatic trypsin inhibitor domain//EamA-like transporter family -- -- GO:0004867 serine-type endopeptidase inhibitor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.10042 BP_3 431.75 7.50 3067 642924544 XP_008194337.1 191 1.4e-11 PREDICTED: endocuticle structural glycoprotein SgAbd-2-like [Tribolium castaneum]>gi|270006763|gb|EFA03211.1| hypothetical protein TcasGA2_TC013131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 175 4.2e-11 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF08089//PF13520//PF00379 Huwentoxin-II family//Amino acid permease//Insect cuticle protein GO:0009405//GO:0006865//GO:0003333 pathogenesis//amino acid transport//amino acid transmembrane transport GO:0015171//GO:0042302 amino acid transmembrane transporter activity//structural constituent of cuticle GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.1005 BP_3 2.09 0.40 542 91089363 XP_973168.1 182 2.8e-11 PREDICTED: protein CIP2A [Tribolium castaneum]>gi|270011435|gb|EFA07883.1| hypothetical protein TcasGA2_TC005457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10051 BP_3 2.27 1.26 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10057 BP_3 25.25 0.51 2693 642933178 XP_008197290.1 1099 6.4e-117 PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X2 [Tribolium castaneum] 430763429 JQ753065.1 49 7.0229e-14 Aedes aegypti strain Liverpool Kir1 channel protein mRNA, complete cds K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 Q14500 609 1.7e-61 ATP-sensitive inward rectifier potassium channel 12 OS=Homo sapiens GN=KCNJ12 PE=1 SV=2 PF00520//PF01007 Ion transport protein//Inward rectifier potassium channel GO:0055085//GO:0006813//GO:0006811 transmembrane transport//potassium ion transport//ion transport GO:0005242//GO:0005216 inward rectifier potassium channel activity//ion channel activity GO:0016021//GO:0016020//GO:0008076 integral component of membrane//membrane//voltage-gated potassium channel complex KOG3827 Inward rectifier K+ channel Cluster-8309.10059 BP_3 76.00 2.06 2072 642915340 XP_008190579.1 1474 1.6e-160 PREDICTED: adenosine deaminase CECR1-A-like [Tribolium castaneum]>gi|270003891|gb|EFA00339.1| hypothetical protein TcasGA2_TC003178 [Tribolium castaneum] -- -- -- -- -- K19572 CECR1, ADA2 adenosine deaminase CECR1 http://www.genome.jp/dbget-bin/www_bget?ko:K19572 P15287 924 4.0e-98 Adenosine deaminase AGSA OS=Aplysia californica PE=1 SV=2 PF08451//PF00962 Adenosine/AMP deaminase N-terminal//Adenosine/AMP deaminase -- -- GO:0019239 deaminase activity GO:0005615 extracellular space -- -- Cluster-8309.10061 BP_3 139.30 2.72 2757 642925599 XP_008194616.1 542 2.5e-52 PREDICTED: hornerin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13892//PF01607 DNA-binding domain//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0003677//GO:0008061 DNA binding//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.10064 BP_3 517.42 10.25 2726 91091892 XP_970427.1 1227 9.3e-132 PREDICTED: uncharacterized protein C9orf114 homolog [Tribolium castaneum]>gi|270001126|gb|EEZ97573.1| hypothetical protein TcasGA2_TC011435 [Tribolium castaneum] -- -- -- -- -- K09142 K09142 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K09142 Q3UHX9 886 1.3e-93 Putative methyltransferase C9orf114 homolog OS=Mus musculus GN=D2Wsu81e PE=2 SV=1 PF00076//PF00588 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//SpoU rRNA Methylase family GO:0006396//GO:0009451 RNA processing//RNA modification GO:0008173//GO:0003723//GO:0003676 RNA methyltransferase activity//RNA binding//nucleic acid binding -- -- KOG3925 Uncharacterized conserved protein Cluster-8309.10069 BP_3 15.56 6.78 401 91083843 XP_973852.1 326 4.1e-28 PREDICTED: larval cuticle protein LCP-30 [Tribolium castaneum]>gi|270006765|gb|EFA03213.1| hypothetical protein TcasGA2_TC013133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F1 233 1.0e-18 Endocuticle structural glycoprotein SgAbd-4 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.10083 BP_3 9.00 0.78 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10089 BP_3 2.00 4.34 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10091 BP_3 2.00 1.23 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10095 BP_3 28.00 1.03 1605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.101 BP_3 27.93 1.74 1066 270002934 EEZ99381.1 311 6.0e-26 prothoracicotropic hormone [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17219 131 1.8e-06 Prothoracicotropic hormone OS=Bombyx mori PE=1 SV=1 PF06083 Interleukin-17 GO:0006954//GO:0007165 inflammatory response//signal transduction GO:0005125 cytokine activity GO:0005576 extracellular region -- -- Cluster-8309.10102 BP_3 3.00 2.48 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1011 BP_3 15.00 0.45 1902 -- -- -- -- -- 697068032 XM_009650906.1 1464 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF04923//PF01284 Ninjurin//Membrane-associating domain GO:0042246//GO:0007155 tissue regeneration//cell adhesion -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.10113 BP_3 6.27 0.93 616 546684308 ERL94013.1 165 2.9e-09 hypothetical protein D910_11297 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.10115 BP_3 5.03 0.61 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1012 BP_3 2.00 0.47 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10121 BP_3 71.00 3.62 1238 675883262 XP_009027133.1 471 1.9e-44 hypothetical protein HELRODRAFT_193782 [Helobdella robusta]>gi|555691541|gb|ESN94773.1| hypothetical protein HELRODRAFT_193782 [Helobdella robusta] -- -- -- -- -- K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q9TSM6 421 5.0e-40 Protein tyrosine phosphatase type IVA 1 OS=Macaca fascicularis GN=PTP4A1 PE=1 SV=1 PF00782//PF00102//PF05706 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.10126 BP_3 5.82 0.69 698 642915652 XP_008190697.1 548 1.3e-53 PREDICTED: integrin-alpha FG-GAP repeat-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27969 143 4.9e-08 Integrin-alpha FG-GAP repeat-containing protein 2 OS=Bos taurus GN=ITFG2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10128 BP_3 111.00 11.05 776 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07359 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) GO:0042742 defense response to bacterium -- -- -- -- -- -- Cluster-8309.10129 BP_3 9.00 5.65 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10130 BP_3 292.00 18.32 1060 91079418 XP_967497.1 1072 3.4e-114 PREDICTED: exosome complex component RRP42 [Tribolium castaneum]>gi|642917207|ref|XP_008191163.1| PREDICTED: exosome complex component RRP42 [Tribolium castaneum]>gi|270003471|gb|EEZ99918.1| hypothetical protein TcasGA2_TC002710 [Tribolium castaneum] -- -- -- -- -- K12589 RRP42, EXOSC7 exosome complex component RRP42 http://www.genome.jp/dbget-bin/www_bget?ko:K12589 Q9D0M0 636 5.1e-65 Exosome complex exonuclease RRP42 OS=Mus musculus GN=Exosc7 PE=2 SV=2 PF06338//PF00501 ComK protein//AMP-binding enzyme GO:0030420//GO:0008152 establishment of competence for transformation//metabolic process GO:0003824 catalytic activity -- -- KOG1612 Exosomal 3'-5' exoribonuclease complex, subunit Rrp42 Cluster-8309.10132 BP_3 4.00 0.52 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10140 BP_3 5.00 1.28 480 148693644 EDL25591.1 394 6.4e-36 mCG10725, isoform CRA_b, partial [Mus musculus] 14591916 NM_001028.2 474 0 Homo sapiens ribosomal protein S25 (RPS25), mRNA K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q6Q311 372 9.4e-35 40S ribosomal protein S25 OS=Ovis aries GN=RPS25 PE=2 SV=1 PF01325 Iron dependent repressor, N-terminal DNA binding domain -- -- GO:0003677 DNA binding -- -- KOG1767 40S ribosomal protein S25 Cluster-8309.10143 BP_3 21.58 0.36 3176 642932971 XP_008197211.1 598 9.4e-59 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] 749745516 XM_011157000.1 146 9.93234e-68 PREDICTED: Harpegnathos saltator potassium voltage-gated channel protein Shaw-like (LOC105192704), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 483 8.4e-47 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.10150 BP_3 32.70 0.77 2327 91087271 XP_975540.1 2035 1.6e-225 PREDICTED: TLD domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJX5 624 2.7e-63 TLD domain-containing protein 1 OS=Gallus gallus GN=TLDC1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2557 Uncharacterized conserved protein, contains TLDc domain Cluster-8309.10155 BP_3 32.00 0.56 3061 218683228 ACL00655.1 4172 0.0e+00 trehalose 6-phosphate synthase 1 isoform 1 [Callinectes sapidus] 218683225 EU910086.1 2371 0 Callinectes sapidus trehalose 6-phosphate synthase 1 (TPS1) mRNA, complete cds K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 985 5.0e-105 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF00982//PF02358 Glycosyltransferase family 20//Trehalose-phosphatase GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.10180 BP_3 48.29 0.69 3654 478250336 ENN70833.1 1486 1.2e-161 hypothetical protein YQE_12497, partial [Dendroctonus ponderosae] -- -- -- -- -- K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 Q9NQT8 307 2.5e-26 Kinesin-like protein KIF13B OS=Homo sapiens GN=KIF13B PE=1 SV=2 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule KOG0241 Kinesin-like protein Cluster-8309.10181 BP_3 3.00 0.55 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10182 BP_3 305.96 3.54 4463 478250336 ENN70833.1 2137 4.6e-237 hypothetical protein YQE_12497, partial [Dendroctonus ponderosae] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 837 1.0e-87 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0241 Kinesin-like protein Cluster-8309.10186 BP_3 3.00 1.66 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF00537 Arthropod defensin//Scorpion toxin-like domain GO:0006952//GO:0006810 defense response//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.1019 BP_3 15.00 1.35 826 849976741 AKN46052.1 1192 3.2e-128 trypsin-like serine proteinase [Eriocheir sinensis] 122003893 EF120995.1 286 3.74583e-146 Portunus pelagicus trypsin-like (TRY3) mRNA, partial sequence K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P00765 745 9.0e-78 Trypsin-1 OS=Astacus astacus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.10190 BP_3 80.00 1.80 2439 380003230 AFD28290.1 1252 1.1e-134 14-3-3-like protein [Eriocheir sinensis]>gi|401816688|gb|AFQ20813.1| 14-3-3 [Portunus trituberculatus] 401816687 JX138966.1 2203 0 Portunus trituberculatus 14-3-3 mRNA, complete cds K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 1127 1.4e-121 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 PF06386//PF02154 Gas vesicle synthesis protein GvpL/GvpF//Flagellar motor switch protein FliM GO:0071973//GO:0031412 bacterial-type flagellum-dependent cell motility//gas vesicle organization GO:0003774 motor activity GO:0009425//GO:0031411 bacterial-type flagellum basal body//gas vesicle KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.10192 BP_3 75.00 0.92 4227 262401017 ACY66411.1 1562 2.1e-170 map kinase-interacting serine/threonine [Scylla paramamosain] 262401016 FJ774689.1 868 0 Scylla paramamosain map kinase-interacting serine/threonine mRNA, partial cds K04372 MKNK, MNK MAP kinase interacting serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04372 Q66I46 1186 3.4e-128 MAP kinase-interacting serine/threonine-protein kinase 2 OS=Xenopus tropicalis GN=mknk2 PE=2 SV=1 PF00075//PF01186//PF07714//PF00069//PF06293 RNase H//Lysyl oxidase//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0051252//GO:0055114 protein phosphorylation//regulation of RNA metabolic process//oxidation-reduction process GO:0005507//GO:0005524//GO:0016641//GO:0003676//GO:0016773//GO:0004672//GO:0004523 copper ion binding//ATP binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//nucleic acid binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//RNA-DNA hybrid ribonuclease activity GO:0016020 membrane KOG0607 MAP kinase-interacting kinase and related serine/threonine protein kinases Cluster-8309.10193 BP_3 64.00 1.97 1859 356713486 AET36897.1 617 3.4e-61 troponin C2 [Litopenaeus vannamei] 239949538 FJ790223.1 216 7.05501e-107 Homarus americanus troponin C isoform 4' mRNA, complete cds K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P06708 524 8.6e-52 Troponin C, isotype gamma OS=Astacus leptodactylus PE=1 SV=1 PF02337//PF03874//PF00036//PF13202//PF13499//PF10591//PF13833//PF13405//PF12763//PF02881 Retroviral GAG p10 protein//RNA polymerase Rpb4//EF hand//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand//SRP54-type protein, helical bundle domain GO:0006351//GO:0006614//GO:0007165//GO:0006144//GO:0006206 transcription, DNA-templated//SRP-dependent cotranslational protein targeting to membrane//signal transduction//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0005198//GO:0005515//GO:0005509//GO:0005525 DNA-directed RNA polymerase activity//structural molecule activity//protein binding//calcium ion binding//GTP binding GO:0019028//GO:0005578//GO:0005730 viral capsid//proteinaceous extracellular matrix//nucleolus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.10194 BP_3 21.89 0.77 1667 414448013 AFW99837.1 533 1.7e-51 troponin I [Litopenaeus vannamei] 414448012 JX683728.1 293 9.91125e-150 Litopenaeus vannamei clone TPNi1 troponin I mRNA, complete cds -- -- -- -- P05547 521 1.7e-51 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992 Troponin -- -- -- -- GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.10195 BP_3 21.96 0.97 1388 414448013 AFW99837.1 533 1.4e-51 troponin I [Litopenaeus vannamei] 414448012 JX683728.1 293 8.21687e-150 Litopenaeus vannamei clone TPNi1 troponin I mRNA, complete cds -- -- -- -- P05547 521 1.4e-51 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992//PF02724//PF02601 Troponin//CDC45-like protein//Exonuclease VII, large subunit GO:0006270//GO:0006308 DNA replication initiation//DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0005861//GO:0009318 troponin complex//exodeoxyribonuclease VII complex KOG3977 Troponin I Cluster-8309.10197 BP_3 4.00 0.47 700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03229 Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process -- -- -- -- -- -- Cluster-8309.1020 BP_3 50.00 9.86 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10205 BP_3 38.52 1.04 2072 554523146 XP_005856469.1 677 4.2e-68 PREDICTED: putative uncharacterized zinc finger protein 814-like isoform X1 [Myotis brandtii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 663 7.3e-68 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF13912//PF07776//PF01426//PF13465//PF00096//PF00130 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//BAH domain//Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0046872//GO:0003682//GO:0008270 metal ion binding//chromatin binding//zinc ion binding GO:0000785//GO:0005634 chromatin//nucleus -- -- Cluster-8309.10208 BP_3 6.00 0.51 862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10213 BP_3 1.00 0.61 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10215 BP_3 3.00 0.46 603 642940184 XP_008200534.1 527 3.0e-51 PREDICTED: uncharacterized protein LOC655735 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10218 BP_3 68.21 1.14 3172 861626561 KMQ88832.1 811 1.9e-83 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF03184 helix-turn-helix, Psq domain//DDE superfamily endonuclease -- -- GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.10228 BP_3 92.82 2.86 1855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11023 Zinc-ribbon containing domain -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.10238 BP_3 20.63 1.39 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10249 BP_3 69.22 3.87 1154 478251807 ENN72253.1 849 2.7e-88 hypothetical protein YQE_11116, partial [Dendroctonus ponderosae]>gi|546684744|gb|ERL94354.1| hypothetical protein D910_11635 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AXS8 266 4.4e-22 Tubulin polyglutamylase complex subunit 2 OS=Rattus norvegicus GN=Tpgs2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10250 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04625 DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213 structural constituent of chorion GO:0042600//GO:0005576 chorion//extracellular region -- -- Cluster-8309.10253 BP_3 3.00 0.34 712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10254 BP_3 12.00 0.42 1657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10259 BP_3 307.00 9.90 1786 91077948 XP_966879.1 705 2.1e-71 PREDICTED: ribosome-recycling factor, mitochondrial [Tribolium castaneum]>gi|270002287|gb|EEZ98734.1| hypothetical protein TcasGA2_TC001287 [Tribolium castaneum] -- -- -- -- -- K02838 frr, MRRF, RRF ribosome recycling factor http://www.genome.jp/dbget-bin/www_bget?ko:K02838 Q0VCQ4 386 8.3e-36 Ribosome-recycling factor, mitochondrial OS=Bos taurus GN=MRRF PE=2 SV=1 PF01434 Peptidase family M41 GO:0006412//GO:0006508 translation//proteolysis GO:0004222//GO:0005524 metalloendopeptidase activity//ATP binding GO:0005739 mitochondrion KOG4759 Ribosome recycling factor Cluster-8309.10262 BP_3 9.00 0.65 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10265 BP_3 2.00 0.52 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07425 Pardaxin -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.10266 BP_3 1.00 3.03 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10274 BP_3 5.00 0.62 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10278 BP_3 59.81 2.42 1481 270011134 EFA07582.1 1302 1.0e-140 invected [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10279 BP_3 12.00 0.89 940 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10285 BP_3 33.00 0.53 3266 -- -- -- -- -- 462369191 APGK01026304.1 58 8.47725e-19 Dendroctonus ponderosae Seq01026314, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1029 BP_3 6.93 1.56 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10294 BP_3 1.00 0.50 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10298 BP_3 13.39 0.36 2094 51102795 AAT95992.1 450 9.0e-42 transposase [Drosophila willistoni]>gi|51102803|gb|AAT95996.1| transposase [Drosophila willistoni] -- -- -- -- -- -- -- -- -- Q7M3K2 446 1.1e-42 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF02689//PF05531//PF04977 Helicase//Nucleopolyhedrovirus P10 protein//Septum formation initiator GO:0007049 cell cycle GO:0005524//GO:0004386 ATP binding//helicase activity GO:0019028 viral capsid -- -- Cluster-8309.10302 BP_3 5.00 1.16 500 685833837 CEF68758.1 583 8.1e-58 Polyubiquitin-C [Strongyloides ratti] 768311753 CP010981.1 443 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 P0CG70 589 6.7e-60 Polyubiquitin OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=ubi PE=1 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.10304 BP_3 11.72 0.79 1004 642940305 XP_008199674.1 185 2.3e-11 PREDICTED: uncharacterized protein LOC103314729 [Tribolium castaneum]>gi|270017203|gb|EFA13649.1| hypothetical protein TcasGA2_TC004984 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10305 BP_3 12718.90 1566.73 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1031 BP_3 2.00 1.02 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10310 BP_3 85.70 6.86 894 91076304 XP_969164.1 297 2.1e-24 PREDICTED: eclosion hormone [Tribolium castaneum]>gi|642912177|ref|XP_008200840.1| PREDICTED: eclosion hormone [Tribolium castaneum]>gi|270002925|gb|EEZ99372.1| eclosion hormone [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11919 232 3.0e-18 Eclosion hormone OS=Manduca sexta PE=1 SV=2 PF04736 Eclosion hormone GO:0018990//GO:0007218 ecdysis, chitin-based cuticle//neuropeptide signaling pathway GO:0008255 ecdysis-triggering hormone activity -- -- -- -- Cluster-8309.10314 BP_3 1.00 0.55 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10317 BP_3 46.66 1.34 1973 270001266 EEZ97713.1 444 4.2e-41 cadherin-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10322 BP_3 15.00 0.43 1973 694526129 XP_009492627.1 1923 1.3e-212 ATP synthase subunit alpha, mitochondrial [Fonticula alba]>gi|627951137|gb|KCV72926.1| ATP synthase subunit alpha, mitochondrial [Fonticula alba] 697090410 XM_009659816.1 1760 0 Verticillium dahliae VdLs.17 ATP synthase subunit alpha partial mRNA K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 P37211 2409 2.4e-270 ATP synthase subunit alpha, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=atp-1 PE=3 SV=1 PF00306//PF00006//PF02874//PF03276 ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta family, beta-barrel domain//Spumavirus gag protein GO:0046718//GO:0075521//GO:0015991//GO:0019076//GO:0046034//GO:0015992 viral entry into host cell//microtubule-dependent intracellular transport of viral material towards nucleus//ATP hydrolysis coupled proton transport//viral release from host cell//ATP metabolic process//proton transport GO:0005524//GO:0016820 ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0042025//GO:0019028//GO:0033178//GO:0030430//GO:0044163 host cell nucleus//viral capsid//proton-transporting two-sector ATPase complex, catalytic domain//host cell cytoplasm//host cytoskeleton KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-8309.10325 BP_3 20.00 0.96 1297 347967126 XP_001689309.2 315 2.5e-26 AGAP002074-PA [Anopheles gambiae str. PEST]>gi|333469747|gb|EDO63214.2| AGAP002074-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10328 BP_3 42.26 0.45 4773 801375633 XP_012063602.1 310 3.5e-25 PREDICTED: zinc finger protein 2-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- Q9CXE0 278 7.4e-23 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF13465//PF01844//PF02892//PF01363//PF13912//PF00130//PF00096//PF08996//PF05715//PF06061//PF07776 Zinc-finger double domain//HNH endonuclease//BED zinc finger//FYVE zinc finger//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//DNA Polymerase alpha zinc finger//Piccolo Zn-finger//Baculoviridae ME53//Zinc-finger associated domain (zf-AD) GO:0035556//GO:0006260 intracellular signal transduction//DNA replication GO:0046872//GO:0001882//GO:0003676//GO:0008270//GO:0003887//GO:0003677//GO:0004519 metal ion binding//nucleoside binding//nucleic acid binding//zinc ion binding//DNA-directed DNA polymerase activity//DNA binding//endonuclease activity GO:0045202//GO:0042575//GO:0005634 synapse//DNA polymerase complex//nucleus -- -- Cluster-8309.10330 BP_3 630.00 9.78 3396 768409110 XP_011551077.1 896 2.8e-93 PREDICTED: elongation of very long chain fatty acids protein AAEL008004-like isoform X2 [Plutella xylostella] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 618 2.0e-62 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.10333 BP_3 10.00 0.56 1158 91077092 XP_970105.1 144 1.5e-06 PREDICTED: MYCBP-associated protein [Tribolium castaneum]>gi|270001731|gb|EEZ98178.1| hypothetical protein TcasGA2_TC000607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10335 BP_3 9.00 0.83 814 766925460 XP_011494626.1 563 2.8e-55 PREDICTED: 40S ribosomal protein S15 [Ceratosolen solmsi marchali] 697085122 XM_009657180.1 741 0 Verticillium dahliae VdLs.17 40S ribosomal protein S15 mRNA K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 P34737 645 3.5e-66 40S ribosomal protein S15 OS=Podospora anserina GN=RPS15 PE=3 SV=1 PF00203 Ribosomal protein S19 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0898 40S ribosomal protein S15 Cluster-8309.1034 BP_3 7.00 0.54 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10341 BP_3 2.00 0.89 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10345 BP_3 173.94 3.23 2891 719764165 XP_010216927.1 367 5.2e-32 PREDICTED: collagen alpha-1(I) chain, partial [Tinamus guttatus] -- -- -- -- -- -- -- -- -- P02453 359 1.8e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF10660//PF06482 Iron-containing outer mitochondrial membrane protein N-terminus//Collagenase NC10 and Endostatin GO:0007155 cell adhesion GO:0051537//GO:0005198 2 iron, 2 sulfur cluster binding//structural molecule activity GO:0031012//GO:0043231 extracellular matrix//intracellular membrane-bounded organelle -- -- Cluster-8309.10347 BP_3 1.00 4.43 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10348 BP_3 15.13 0.32 2597 642935459 XP_972294.2 602 2.6e-59 PREDICTED: uncharacterized protein LOC661011 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11298 HMG2L1 high mobility group protein 2-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11298 Q9UGU5 191 4.9e-13 HMG domain-containing protein 4 OS=Homo sapiens GN=HMGXB4 PE=1 SV=2 PF11770 GRB2-binding adapter (GAPT) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.10357 BP_3 1.00 0.93 336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10358 BP_3 11.12 0.69 1066 478253013 ENN73393.1 1144 1.5e-122 hypothetical protein YQE_09955, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A2RU67 192 1.6e-13 Uncharacterized protein KIAA1467 OS=Homo sapiens GN=KIAA1467 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10361 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10363 BP_3 80.03 8.17 764 642930121 XP_008196261.1 342 1.1e-29 PREDICTED: acylphosphatase-1-like [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 P24540 288 8.2e-25 Acylphosphatase-1 OS=Sus scrofa GN=ACYP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3360 Acylphosphatase Cluster-8309.10364 BP_3 1442.63 48.92 1713 642922911 XP_008200448.1 286 7.6e-23 PREDICTED: glutenin, high molecular weight subunit DX5-like [Tribolium castaneum]>gi|270006551|gb|EFA02999.1| hypothetical protein TcasGA2_TC010421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11640 Telomere-length maintenance and DNA damage repair GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674 protein serine/threonine kinase activity -- -- -- -- Cluster-8309.10365 BP_3 40.54 0.49 4249 642929553 XP_008195882.1 2352 5.1e-262 PREDICTED: DNA excision repair protein ERCC-6-like [Tribolium castaneum] 645002912 XM_008209837.1 96 8.30922e-40 PREDICTED: Nasonia vitripennis DNA excision repair protein ERCC-6-like (LOC100118952), transcript variant X3, mRNA K10841 ERCC6, CSB, RAD26 DNA excision repair protein ERCC-6 http://www.genome.jp/dbget-bin/www_bget?ko:K10841 Q03468 1642 4.5e-181 DNA excision repair protein ERCC-6 OS=Homo sapiens GN=ERCC6 PE=1 SV=1 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) Cluster-8309.10367 BP_3 19.76 0.68 1684 260807253 XP_002598423.1 302 1.0e-24 hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae]>gi|229283696|gb|EEN54435.1| hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9NPA5 202 1.7e-14 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF06743//PF13465//PF00096//PF07776 FAST kinase-like protein, subdomain 1//Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0004672//GO:0008270 metal ion binding//protein kinase activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.10368 BP_3 20.69 0.68 1755 260807253 XP_002598423.1 305 4.9e-25 hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae]>gi|229283696|gb|EEN54435.1| hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9NPA5 202 1.8e-14 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF00096//PF13465//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.10369 BP_3 24.42 0.36 3520 189234553 XP_973928.2 1624 1.1e-177 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] 571543566 XM_006559674.1 150 6.58586e-70 PREDICTED: Apis mellifera putative homeodomain transcription factor-like (LOC551885), mRNA -- -- -- -- Q9V9A8 933 6.1e-99 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.10372 BP_3 196.00 9.21 1318 189236180 XP_967893.2 907 5.8e-95 PREDICTED: serine hydrolase-like protein [Tribolium castaneum]>gi|270005749|gb|EFA02197.1| hypothetical protein TcasGA2_TC007853 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2BGU9 342 7.8e-31 Serine hydrolase-like protein OS=Danio rerio GN=serhl PE=2 SV=1 PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.10378 BP_3 2.00 0.40 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10381 BP_3 339.34 3.96 4427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06478//PF03153 Coronavirus RPol N-terminus//Transcription factor IIA, alpha/beta subunit GO:0006144//GO:0006351//GO:0006367 purine nucleobase metabolic process//transcription, DNA-templated//transcription initiation from RNA polymerase II promoter GO:0005524//GO:0003723//GO:0003968 ATP binding//RNA binding//RNA-directed RNA polymerase activity GO:0031379//GO:0005672 RNA-directed RNA polymerase complex//transcription factor TFIIA complex -- -- Cluster-8309.10382 BP_3 5.00 0.33 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10383 BP_3 2371.00 33.69 3684 642911159 XP_008200605.1 1257 4.2e-135 PREDICTED: proclotting enzyme [Tribolium castaneum]>gi|270015119|gb|EFA11567.1| serine protease P53 [Tribolium castaneum] 659100464 KJ512130.1 119 1.17867e-52 Nilaparvata lugens trypsin-19 mRNA, complete cds -- -- -- -- P21902 450 6.5e-43 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.10389 BP_3 9.00 0.78 846 821027387 XP_012356888.1 678 1.3e-68 PREDICTED: profilin-1 isoform X2 [Nomascus leucogenys] 394582017 NM_005022.3 835 0 Homo sapiens profilin 1 (PFN1), mRNA K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 P07737 660 6.6e-68 Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10394 BP_3 97.48 1.70 3059 642933360 XP_008197383.1 319 2.0e-26 PREDICTED: integrin alpha-PS1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24247 207 8.1e-15 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10396 BP_3 16.80 0.36 2536 642933135 XP_973578.2 2406 1.7e-268 PREDICTED: DNA topoisomerase 3-alpha [Tribolium castaneum] 571572814 XM_394050.5 155 7.85777e-73 PREDICTED: Apis mellifera DNA topoisomerase 3-alpha-like (LOC410571), mRNA K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 Q9NG98 1864 4.9e-207 DNA topoisomerase 3-alpha OS=Drosophila melanogaster GN=Top3alpha PE=2 SV=2 PF01396//PF01131//PF01022 Topoisomerase DNA binding C4 zinc finger//DNA topoisomerase//Bacterial regulatory protein, arsR family GO:0006355//GO:0006265 regulation of transcription, DNA-templated//DNA topological change GO:0003677//GO:0003916//GO:0003700 DNA binding//DNA topoisomerase activity//transcription factor activity, sequence-specific DNA binding GO:0005694//GO:0005667 chromosome//transcription factor complex KOG1956 DNA topoisomerase III alpha Cluster-8309.10398 BP_3 16.52 1.39 864 642921367 XP_008192837.1 429 1.0e-39 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K12375 ARSI_J arylsulfatase I/J http://www.genome.jp/dbget-bin/www_bget?ko:K12375 P50430 212 6.0e-16 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.10399 BP_3 17.93 0.57 1813 642939603 XP_008194617.1 421 1.8e-38 PREDICTED: uncharacterized protein LOC103313343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.104 BP_3 32.00 6.11 544 91086999 XP_973764.1 438 5.7e-41 PREDICTED: radial spoke head protein 6 homolog A [Tribolium castaneum]>gi|270009637|gb|EFA06085.1| hypothetical protein TcasGA2_TC008922 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BYM7 301 1.8e-26 Radial spoke head protein 4 homolog A OS=Mus musculus GN=Rsph4a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1040 BP_3 20.22 1.16 1129 189239979 XP_001808109.1 211 2.5e-14 PREDICTED: uncharacterized protein LOC100142168 [Tribolium castaneum]>gi|270011814|gb|EFA08262.1| hypothetical protein TcasGA2_TC005890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05552 146 3.5e-08 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.10401 BP_3 4.00 1.04 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10408 BP_3 5.00 0.50 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10409 BP_3 52.29 0.96 2923 270011077 EFA07525.1 1399 1.1e-151 torso [Tribolium castaneum] 26102928 AK085723.1 38 9.94118e-08 Mus musculus 10 days lactation, adult female mammary gland cDNA, RIKEN full-length enriched library, clone:D730027I24 product:fibroblast growth factor receptor 4, full insert sequence K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 G3V9H8 689 1.0e-70 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Rattus norvegicus GN=Ret PE=1 SV=1 PF00041//PF07714//PF00069 Fibronectin type III domain//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.10413 BP_3 18.33 1.26 992 667755293 AIG92783.1 612 7.0e-61 extracellular superoxide dismutase [Dastarcus helophoroides] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 373 1.5e-34 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.1042 BP_3 4.40 0.36 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10428 BP_3 1.00 0.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1043 BP_3 3.00 0.37 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10433 BP_3 30.48 1.28 1441 642913546 XP_008201056.1 290 2.2e-23 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- K08209 SLC22A13 MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08209 Q6A4L0 185 1.4e-12 Solute carrier family 22 member 13 OS=Mus musculus GN=Slc22a13 PE=2 SV=3 PF00324 Amino acid permease GO:0055085//GO:0006810 transmembrane transport//transport -- -- GO:0016020 membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.10437 BP_3 6.01 2.03 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10440 BP_3 119.24 1.03 5862 478257774 ENN77917.1 2916 0.0e+00 hypothetical protein YQE_05594, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B2GUN4 1110 3.0e-119 Meiosis arrest female protein 1 homolog OS=Xenopus tropicalis GN=marf1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.10444 BP_3 8.00 1.19 615 642935261 XP_008197937.1 841 1.2e-87 PREDICTED: tetratricopeptide repeat protein 8 [Tribolium castaneum] -- -- -- -- -- K16781 TTC8, BBS8 tetratricopeptide repeat protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K16781 Q8VD72 513 5.4e-51 Tetratricopeptide repeat protein 8 OS=Mus musculus GN=Ttc8 PE=1 SV=1 PF13174//PF00515 Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1129 TPR repeat-containing protein Cluster-8309.10450 BP_3 16.13 0.70 1405 270003361 EEZ99808.1 933 5.9e-98 hypothetical protein TcasGA2_TC002588 [Tribolium castaneum] -- -- -- -- -- K10578 UBE2J1, NCUBE1, UBC6 ubiquitin-conjugating enzyme E2 J1 http://www.genome.jp/dbget-bin/www_bget?ko:K10578 Q9JJZ4 663 5.0e-68 Ubiquitin-conjugating enzyme E2 J1 OS=Mus musculus GN=Ube2j1 PE=1 SV=2 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0894 Ubiquitin-protein ligase Cluster-8309.10451 BP_3 155.16 5.63 1619 270003361 EEZ99808.1 933 6.8e-98 hypothetical protein TcasGA2_TC002588 [Tribolium castaneum] -- -- -- -- -- K10578 UBE2J1, NCUBE1, UBC6 ubiquitin-conjugating enzyme E2 J1 http://www.genome.jp/dbget-bin/www_bget?ko:K10578 Q9JJZ4 663 5.7e-68 Ubiquitin-conjugating enzyme E2 J1 OS=Mus musculus GN=Ube2j1 PE=1 SV=2 PF08043//PF05773 Xin repeat//RWD domain GO:0030036 actin cytoskeleton organization GO:0005515//GO:0003779 protein binding//actin binding GO:0030054 cell junction KOG0894 Ubiquitin-protein ligase Cluster-8309.10455 BP_3 40.96 1.91 1327 820805550 AKG92766.1 799 1.9e-82 Mlx interactor [Leptinotarsa decemlineata] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9HAP2 261 1.9e-21 MLX-interacting protein OS=Homo sapiens GN=MLXIP PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3582 Mlx interactors and related transcription factors Cluster-8309.10460 BP_3 279.51 1.14 12133 546678376 ERL89009.1 15444 0.0e+00 hypothetical protein D910_06387 [Dendroctonus ponderosae] 861437320 XM_013072408.1 160 6.31059e-75 PREDICTED: Heterocephalus glaber dynein, axonemal, heavy chain 5 (Dnah5), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q96JB1 11100 0.0e+00 Dynein heavy chain 8, axonemal OS=Homo sapiens GN=DNAH8 PE=1 SV=2 PF07728//PF11112//PF09520//PF00004//PF03028//PF00910 AAA domain (dynein-related subfamily)//Pyocin activator protein PrtN//Type II restriction endonuclease, TdeIII//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor//RNA helicase GO:0006355//GO:0007017//GO:0009307//GO:0006308//GO:0007018 regulation of transcription, DNA-templated//microtubule-based process//DNA restriction-modification system//DNA catabolic process//microtubule-based movement GO:0016887//GO:0003724//GO:0005524//GO:0003723//GO:0009036//GO:0003677//GO:0003777 ATPase activity//RNA helicase activity//ATP binding//RNA binding//Type II site-specific deoxyribonuclease activity//DNA binding//microtubule motor activity GO:0009359//GO:0030286//GO:0005874 Type II site-specific deoxyribonuclease complex//dynein complex//microtubule -- -- Cluster-8309.10461 BP_3 1.00 0.32 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10464 BP_3 34.32 0.43 4147 642935202 XP_008199688.1 1752 1.9e-192 PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|642935204|ref|XP_008199689.1| PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|270014185|gb|EFA10633.1| hypothetical protein TcasGA2_TC016270 [Tribolium castaneum] 642935203 XM_008201467.1 274 9.10461e-139 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 945 2.9e-100 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10465 BP_3 12.91 0.61 1315 644991565 XP_008202596.1 550 1.4e-53 PREDICTED: muscle calcium channel subunit alpha-1 isoform X1 [Nasonia vitripennis] 642911060 XM_008202336.1 102 1.16663e-43 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 505 9.7e-50 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.10466 BP_3 34.07 0.77 2433 189240709 XP_001813711.1 1020 8.4e-108 PREDICTED: acyl-CoA synthetase family member 2, mitochondrial [Tribolium castaneum]>gi|270013541|gb|EFA09989.1| hypothetical protein TcasGA2_TC012154 [Tribolium castaneum] -- -- -- -- -- K00666 K00666 fatty-acyl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00666 Q0P4F7 662 1.1e-67 Acyl-CoA synthetase family member 2, mitochondrial OS=Danio rerio GN=acsf2 PE=2 SV=1 PF00501//PF08290 AMP-binding enzyme//Hepatitis core protein, putative zinc finger GO:0008152//GO:0009405 metabolic process//pathogenesis GO:0003824//GO:0005198 catalytic activity//structural molecule activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.10467 BP_3 5.00 0.34 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10469 BP_3 9.13 0.59 1037 119609905 EAW89499.1 446 1.3e-41 synaptogyrin 2, isoform CRA_a [Homo sapiens]>gi|119609908|gb|EAW89502.1| synaptogyrin 2, isoform CRA_a [Homo sapiens] 20987256 BC029755.1 1020 0 Homo sapiens synaptogyrin 2, mRNA (cDNA clone MGC:21859 IMAGE:4341106), complete cds -- -- -- -- O43760 446 5.3e-43 Synaptogyrin-2 OS=Homo sapiens GN=SYNGR2 PE=1 SV=1 PF03882 KicB killing factor GO:0007059//GO:0006260 chromosome segregation//DNA replication GO:0005509 calcium ion binding GO:0008021//GO:0005737//GO:0016021 synaptic vesicle//cytoplasm//integral component of membrane -- -- Cluster-8309.10475 BP_3 2371.38 54.21 2400 642925568 XP_008194603.1 162 2.6e-08 PREDICTED: chorion peroxidase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10477 BP_3 1.00 5.03 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10478 BP_3 182.00 13.45 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10479 BP_3 16.00 1.90 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10483 BP_3 1.00 3.12 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10486 BP_3 24.04 0.88 1609 642918318 XP_008191457.1 453 3.1e-42 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642918317 XM_008193235.1 135 6.48827e-62 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC656006), mRNA K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9ERC8 218 2.3e-16 Down syndrome cell adhesion molecule homolog OS=Mus musculus GN=Dscam PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10487 BP_3 46.25 0.58 4119 642925256 XP_008194482.1 634 8.1e-63 PREDICTED: uncharacterized protein LOC660239 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00688 TGF-beta propeptide GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.10489 BP_3 265.00 4.19 3337 91092544 XP_968085.1 3696 0.0e+00 PREDICTED: pre-mRNA-splicing factor SYF1 [Tribolium castaneum] 820865169 XM_003698678.2 629 0 PREDICTED: Apis florea pre-mRNA-splicing factor SYF1 (LOC100869086), transcript variant X1, mRNA K12867 SYF1, XAB2 pre-mRNA-splicing factor SYF1 http://www.genome.jp/dbget-bin/www_bget?ko:K12867 Q9DCD2 2766 1.6e-311 Pre-mRNA-splicing factor SYF1 OS=Mus musculus GN=Xab2 PE=2 SV=1 PF13374//PF00515//PF13414//PF13176//PF07378//PF05225//PF13181//PF05843 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Flagellar protein FlbT//helix-turn-helix, Psq domain//Tetratricopeptide repeat//Suppressor of forked protein (Suf) GO:1902209//GO:0006402//GO:0006397 negative regulation of bacterial-type flagellum assembly//mRNA catabolic process//mRNA processing GO:0005515//GO:0003677//GO:0048027 protein binding//DNA binding//mRNA 5'-UTR binding GO:0005634 nucleus KOG2047 mRNA splicing factor Cluster-8309.10493 BP_3 10.86 0.36 1732 570341962 AHE77378.1 332 3.6e-28 small heat shock protein, partial [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 227 2.2e-17 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- KOG3591 Alpha crystallins Cluster-8309.10495 BP_3 12.00 0.60 1262 -- -- -- -- -- 404312703 AC253543.1 1114 0 Prunus persica clone JGIBIXB-13M5, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.105 BP_3 59.97 2.83 1314 91086999 XP_973764.1 854 8.0e-89 PREDICTED: radial spoke head protein 6 homolog A [Tribolium castaneum]>gi|270009637|gb|EFA06085.1| hypothetical protein TcasGA2_TC008922 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1L0Z6 418 1.2e-39 Radial spoke head protein 6 homolog A OS=Xenopus tropicalis GN=rsph6a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1050 BP_3 6.75 0.85 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10508 BP_3 19.28 1.02 1207 294944801 XP_002784437.1 747 1.9e-76 conserved hypothetical protein [Perkinsus marinus ATCC 50983]>gi|239897471|gb|EER16233.1| conserved hypothetical protein [Perkinsus marinus ATCC 50983] 697066262 XM_009650023.1 1076 0 Verticillium dahliae VdLs.17 STI35 protein mRNA -- -- -- -- P23618 1126 8.7e-122 Thiamine thiazole synthase OS=Fusarium oxysporum GN=sti35 PE=1 SV=2 PF12831//PF01134//PF07992//PF05834//PF01266//PF01494 FAD dependent oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//FAD binding domain GO:0016117//GO:0055114//GO:0008033 carotenoid biosynthetic process//oxidation-reduction process//tRNA processing GO:0016705//GO:0071949//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//flavin adenine dinucleotide binding//oxidoreductase activity -- -- KOG2960 Protein involved in thiamine biosynthesis and DNA damage tolerance Cluster-8309.10511 BP_3 12.50 1.07 853 91091178 XP_971714.1 453 1.6e-42 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q9EPL9 308 4.4e-27 Peroxisomal acyl-coenzyme A oxidase 3 OS=Mus musculus GN=Acox3 PE=1 SV=2 PF00441//PF01756 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA oxidase GO:0055114//GO:0006635//GO:0044710//GO:0006637 oxidation-reduction process//fatty acid beta-oxidation//single-organism metabolic process//acyl-CoA metabolic process GO:0016627//GO:0003997 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.10513 BP_3 116.00 4.84 1448 91081587 XP_975337.1 1067 1.8e-113 PREDICTED: programmed cell death protein 2 [Tribolium castaneum]>gi|270005104|gb|EFA01552.1| hypothetical protein TcasGA2_TC007113 [Tribolium castaneum] -- -- -- -- -- K14801 TSR4 pre-rRNA-processing protein TSR4 http://www.genome.jp/dbget-bin/www_bget?ko:K14801 P47816 695 9.9e-72 Programmed cell death protein 2 OS=Rattus norvegicus GN=Pdcd2 PE=2 SV=2 PF04194 Programmed cell death protein 2, C-terminal putative domain -- -- -- -- GO:0005737 cytoplasm KOG2061 Uncharacterized MYND Zn-finger protein Cluster-8309.10518 BP_3 18.00 5.83 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1052 BP_3 11.10 0.58 1208 478251883 ENN72321.1 587 6.7e-58 hypothetical protein YQE_10956, partial [Dendroctonus ponderosae]>gi|478266366|gb|ENN82770.1| hypothetical protein YQE_00861, partial [Dendroctonus ponderosae] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 329 2.3e-29 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF03522 Solute carrier family 12 GO:0006811//GO:0006810 ion transport//transport GO:0005215 transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.10525 BP_3 5.25 0.38 964 645040310 XP_008206609.1 174 4.2e-10 PREDICTED: uncharacterized protein LOC100114014 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.10528 BP_3 13.66 1.54 720 91089817 XP_969063.1 215 5.5e-15 PREDICTED: protein anon-73B1 [Tribolium castaneum]>gi|270013595|gb|EFA10043.1| hypothetical protein TcasGA2_TC012215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01741//PF06783 Large-conductance mechanosensitive channel, MscL//Uncharacterised protein family (UPF0239) GO:0006811//GO:0006810 ion transport//transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.1053 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10532 BP_3 96.39 1.27 3964 642938488 XP_008197979.1 2563 1.6e-286 PREDICTED: rho guanine nucleotide exchange factor 9 isoform X3 [Tribolium castaneum] 805759873 XM_012297744.1 247 8.88593e-124 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 1.6e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- -- -- Cluster-8309.10542 BP_3 138.68 5.91 1423 478260397 ENN80137.1 655 1.0e-65 hypothetical protein YQE_03429, partial [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P20432 578 3.6e-58 Glutathione S-transferase 1-1 OS=Drosophila melanogaster GN=GstD1 PE=1 SV=1 PF13409//PF04371//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Porphyromonas-type peptidyl-arginine deiminase//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0009446//GO:0006807 putrescine biosynthetic process//nitrogen compound metabolic process GO:0005515//GO:0004668 protein binding//protein-arginine deiminase activity -- -- -- -- Cluster-8309.10548 BP_3 3828.39 141.37 1597 91081053 XP_975382.1 1024 1.9e-108 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270005322|gb|EFA01770.1| hypothetical protein TcasGA2_TC007369 [Tribolium castaneum] -- -- -- -- -- K00019 E1.1.1.30, bdh 3-hydroxybutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00019 P29147 243 2.8e-19 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Bdh1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.10554 BP_3 130.67 1.59 4251 642910211 XP_008198422.1 662 4.8e-66 PREDICTED: cation-independent mannose-6-phosphate receptor [Tribolium castaneum]>gi|642910213|ref|XP_008198425.1| PREDICTED: cation-independent mannose-6-phosphate receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11717 212 3.0e-15 Cation-independent mannose-6-phosphate receptor OS=Homo sapiens GN=IGF2R PE=1 SV=3 PF00878 Cation-independent mannose-6-phosphate receptor repeat GO:0006810 transport GO:0005215 transporter activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.1056 BP_3 4763.98 485.18 765 546678293 ERL88946.1 206 6.5e-14 hypothetical protein D910_06324 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.10564 BP_3 7.00 0.63 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10569 BP_3 5.00 0.65 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1057 BP_3 164.78 4.10 2230 546678293 ERL88946.1 193 6.0e-12 hypothetical protein D910_06324 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10572 BP_3 17.37 0.82 1319 642918266 XP_008191438.1 961 3.1e-101 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 883 1.4e-93 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.10573 BP_3 39.71 1.60 1491 332374108 AEE62195.1 801 1.3e-82 unknown [Dendroctonus ponderosae]>gi|478251122|gb|ENN71598.1| hypothetical protein YQE_11697, partial [Dendroctonus ponderosae]>gi|546680336|gb|ERL90622.1| hypothetical protein D910_07969 [Dendroctonus ponderosae] -- -- -- -- -- K06971 K06971 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06971 Q1NZ26 497 9.3e-49 Uncharacterized protein F13E9.13, mitochondrial OS=Caenorhabditis elegans GN=F13E9.13 PE=3 SV=1 PF00977//PF00290//PF02679 Histidine biosynthesis protein//Tryptophan synthase alpha chain//(2R)-phospho-3-sulfolactate synthase (ComA) GO:0009094//GO:0006568//GO:0000162//GO:0019295//GO:0006571//GO:0000105 L-phenylalanine biosynthetic process//tryptophan metabolic process//tryptophan biosynthetic process//coenzyme M biosynthetic process//tyrosine biosynthetic process//histidine biosynthetic process GO:0004834 tryptophan synthase activity -- -- -- -- Cluster-8309.10574 BP_3 5.29 0.76 628 332374108 AEE62195.1 352 6.2e-31 unknown [Dendroctonus ponderosae]>gi|478251122|gb|ENN71598.1| hypothetical protein YQE_11697, partial [Dendroctonus ponderosae]>gi|546680336|gb|ERL90622.1| hypothetical protein D910_07969 [Dendroctonus ponderosae] -- -- -- -- -- K06971 K06971 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06971 Q1NZ26 167 7.2e-11 Uncharacterized protein F13E9.13, mitochondrial OS=Caenorhabditis elegans GN=F13E9.13 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10575 BP_3 3.00 0.40 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10581 BP_3 4.00 0.72 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10583 BP_3 30.31 0.73 2296 642934129 XP_008199288.1 888 1.6e-92 PREDICTED: putative zinc metalloproteinase YIL108W isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10588 BP_3 17.69 0.68 1545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09377 SBDS protein C-terminal domain GO:0042254 ribosome biogenesis -- -- -- -- -- -- Cluster-8309.1059 BP_3 31.97 3.86 691 189240378 XP_001814021.1 153 8.1e-08 PREDICTED: uncharacterized protein LOC100141739 [Tribolium castaneum]>gi|270012459|gb|EFA08907.1| hypothetical protein TcasGA2_TC006612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10597 BP_3 4.00 1.14 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10598 BP_3 30.45 0.59 2780 642934625 XP_972040.2 1470 6.3e-160 PREDICTED: atrial natriuretic peptide-converting enzyme isoform X1 [Tribolium castaneum] 752897157 XM_011268569.1 48 2.60859e-13 PREDICTED: Camponotus floridanus atrial natriuretic peptide-converting enzyme-like (LOC105257738), mRNA -- -- -- -- Q9Z319 271 2.8e-22 Atrial natriuretic peptide-converting enzyme OS=Mus musculus GN=Corin PE=2 SV=2 PF00057//PF00089 Low-density lipoprotein receptor domain class A//Trypsin GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.10599 BP_3 3.00 0.62 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1060 BP_3 8.00 1.05 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10600 BP_3 8.00 0.51 1053 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10601 BP_3 13.12 0.62 1306 642919460 XP_008191878.1 200 5.5e-13 PREDICTED: transcription factor IIIA-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34694 162 5.7e-10 Transcription factor IIIA OS=Anaxyrus americanus GN=gtf3a PE=2 SV=1 PF00096//PF13465//PF16622//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.10605 BP_3 8.32 0.79 802 546677172 ERL88062.1 229 1.5e-16 hypothetical protein D910_05451 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10609 BP_3 9.00 1.27 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1061 BP_3 7.00 0.93 653 163915147 NP_001106556.1 663 5.6e-67 histone cluster 1, H3g protein [Xenopus (Silurana) tropicalis]>gi|398395968|ref|XP_003851442.1| histone H3 [Zymoseptoria tritici IPO323]>gi|597584493|ref|XP_007295303.1| histone cluster 1, H3g [Marssonina brunnea f. sp. 'multigermtubi' MB_m1]>gi|627806865|ref|XP_007676780.1| hypothetical protein BAUCODRAFT_34428 [Baudoinia compniacensis UAMH 10762]>gi|628243403|ref|XP_007723998.1| histone H3 [Capronia coronata CBS 617.96]>gi|628279480|ref|XP_007731960.1| histone H3 [Capronia epimyces CBS 606.96]>gi|628303553|ref|XP_007759802.1| histone H3 [Cladophialophora yegresii CBS 114405]>gi|628310228|ref|XP_007740993.1| histone H3 [Cladophialophora psammophila CBS 110553]>gi|629637342|ref|XP_007787317.1| Histone H3 [Endocarpon pusillum Z07020]>gi|631387392|ref|XP_007928076.1| hypothetical protein MYCFIDRAFT_76942 [Pseudocercospora fijiensis CIRAD86]>gi|636769873|ref|XP_008087110.1| Histone-fold containing protein [Glarea lozoyensis ATCC 20868]>gi|667833452|ref|XP_007780895.1| histone H3 [Coniosporium apollinis CBS 100218]>gi|671169146|ref|XP_008725039.1| histone H3 [Cladophialophora carrionii CBS 160.54]>gi|684160423|ref|XP_009154089.1| histone H3 [Exophiala dermatitidis NIH/UT8656]>gi|831340898|ref|XP_012740301.1| histone H3 [Pseudogymnoascus destructans 20631-21]>gi|159155453|gb|AAI54937.1| LOC100127748 protein [Xenopus (Silurana) tropicalis]>gi|339471322|gb|EGP86418.1| histone H3 [Zymoseptoria tritici IPO323]>gi|361125603|gb|EHK97637.1| putative Histone H3 [Glarea lozoyensis 74030]>gi|378727169|gb|EHY53628.1| histone H3 [Exophiala dermatitidis NIH/UT8656]>gi|406861639|gb|EKD14693.1| histone cluster 1, H3g [Marssonina brunnea f. sp. 'multigermtubi' MB_m1]>gi|440635903|gb|ELR05822.1| histone H3 [Pseudogymnoascus destructans 20631-21]>gi|449299646|gb|EMC95659.1| hypothetical protein BAUCODRAFT_34428 [Baudoinia compniacensis UAMH 10762]>gi|452840172|gb|EME42110.1| hypothetical protein DOTSEDRAFT_89592 [Dothistroma septosporum NZE10]>gi|452981244|gb|EME81004.1| hypothetical protein MYCFIDRAFT_76942 [Pseudocercospora fijiensis CIRAD86]>gi|494828793|gb|EON65578.1| histone H3 [Coniosporium apollinis CBS 100218]>gi|512196955|gb|EPE25791.1| Histone-fold containing protein [Glarea lozoyensis ATCC 20868]>gi|521774783|gb|EPQ65912.1| histone H3 protein [Blumeria graminis f. sp. tritici 96224]>gi|521775287|gb|EPQ66293.1| hypothetical protein BGT96224_1778 [Blumeria graminis f. sp. tritici 96224]>gi|528289447|emb|CCU82995.1| histone H3 [Blumeria graminis f. sp. hordei DH14]>gi|528289743|emb|CCU82905.1| Histone H3 [Blumeria graminis f. sp. hordei DH14]>gi|539439791|gb|ERF75305.1| Histone H3 [Endocarpon pusillum Z07020]>gi|565936491|gb|ETI25694.1| histone H3 [Cladophialophora carrionii CBS 160.54]>gi|589973950|gb|EXJ57268.1| histone H3 [Cladophialophora yegresii CBS 114405]>gi|589992909|gb|EXJ75491.1| histone H3 [Cladophialophora psammophila CBS 110553]>gi|590011477|gb|EXJ86681.1| histone H3 [Capronia epimyces CBS 606.96]>gi|590012789|gb|EXJ87992.1| histone H3 [Capronia coronata CBS 617.96]>gi|662503476|gb|KEQ61096.1| histone cluster 1, H3g protein [Aureobasidium melanogenum CBS 110374]>gi|662517202|gb|KEQ74764.1| histone cluster 1, H3g protein [Aureobasidium namibiae CBS 147.97]>gi|662522530|gb|KEQ79930.1| histone cluster 1, H3g protein [Aureobasidium pullulans EXF-150]>gi|662537605|gb|KEQ94913.1| hypothetical protein AUEXF2481DRAFT_47053 [Aureobasidium subglaciale EXF-2481]>gi|682264707|gb|KFX90910.1| hypothetical protein V490_06204 [Pseudogymnoascus pannorum VKM F-3557]>gi|682298646|gb|KFY11630.1| hypothetical protein V491_07122 [Pseudogymnoascus pannorum VKM F-3775]>gi|682310801|gb|KFY18979.1| hypothetical protein V493_08218 [Pseudogymnoascus pannorum VKM F-4281 (FW-2241)]>gi|682335904|gb|KFY32699.1| hypothetical protein V495_08820 [Pseudogymnoascus pannorum VKM F-4514 (FW-929)]>gi|682352562|gb|KFY43528.1| hypothetical protein V494_01929 [Pseudogymnoascus pannorum VKM F-4513 (FW-928)]>gi|682364582|gb|KFY51481.1| hypothetical protein V497_09097 [Pseudogymnoascus pannorum VKM F-4516 (FW-969)]>gi|682382019|gb|KFY64841.1| hypothetical protein V496_02986 [Pseudogymnoascus pannorum VKM F-4515 (FW-2607)]>gi|682391604|gb|KFY71342.1| hypothetical protein V499_08457 [Pseudogymnoascus pannorum VKM F-103]>gi|682429744|gb|KFY96041.1| hypothetical protein V498_02955 [Pseudogymnoascus pannorum VKM F-4517 (FW-2822)]>gi|682433194|gb|KFY98548.1| hypothetical protein V500_01622 [Pseudogymnoascus pannorum VKM F-4518 (FW-2643)]>gi|682459550|gb|KFZ16392.1| hypothetical protein V502_05116 [Pseudogymnoascus pannorum VKM F-4520 (FW-2644)]>gi|682460211|gb|KFZ16836.1| hypothetical protein V501_02045 [Pseudogymnoascus pannorum VKM F-4519 (FW-2642)]>gi|730173199|gb|KHJ30903.1| putative histone H3 [Erysiphe necator]>gi|730177277|gb|KHJ32105.1| putative histone H3 [Erysiphe necator]>gi|751753274|gb|KIN01453.1| hypothetical protein OIDMADRAFT_19281 [Oidiodendron maius Zn]>gi|752281883|dbj|GAM82027.1| hypothetical protein ANO11243_000060 [fungal sp. No.11243]>gi|759202334|gb|KIV79754.1| histone H3 [Exophiala sideris]>gi|759217569|gb|KIV94907.1| histone H3 [Exophiala mesophila]>gi|759228461|gb|KIW05440.1| histone H3 [Verruconis gallopava]>gi|759233623|gb|KIW10573.1| histone H3 [Exophiala spinifera]>gi|759246949|gb|KIW23618.1| histone H3 [Cladophialophora immunda]>gi|759270050|gb|KIW46569.1| histone H3 [Exophiala oligosperma]>gi|759276957|gb|KIW53464.1| histone H3 [Exophiala xenobiotica]>gi|759289378|gb|KIW65871.1| histone H3 [Capronia semiimmersa]>gi|759307563|gb|KIW83967.1| histone H3 [Fonsecaea pedrosoi CBS 271.37]>gi|759321365|gb|KIW97707.1| histone H3 [Cladophialophora bantiana CBS 173.52]>gi|759327035|gb|KIX03364.1| histone H3 [Rhinocladiella mackenziei CBS 650.93]>gi|761342811|gb|KIY03681.1| histone H3 [Fonsecaea multimorphosa CBS 102226]>gi|796696314|gb|KJX95006.1| histone H3.3 like protein [Zymoseptoria brevis]>gi|821062374|gb|KKY17757.1| putative histone H3 [Phaeomoniella chlamydospora] 697081223 XM_009655792.1 642 0 Verticillium dahliae VdLs.17 histone H3 mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P61835 671 2.7e-69 Histone H3 OS=Hypocrea jecorina GN=HHT1 PE=3 SV=2 PF15715//PF00125 PCNA-associated factor//Core histone H2A/H2B/H3/H4 GO:0006974//GO:0006334//GO:0051726 cellular response to DNA damage stimulus//nucleosome assembly//regulation of cell cycle GO:0046982//GO:0003677 protein heterodimerization activity//DNA binding GO:0000786//GO:0005634 nucleosome//nucleus KOG1745 Histones H3 and H4 Cluster-8309.10613 BP_3 13.61 0.75 1170 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10615 BP_3 1.00 1.05 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10624 BP_3 5.61 0.46 880 571551224 XP_006567652.1 178 1.3e-10 PREDICTED: zinc finger protein 331-like [Apis mellifera] -- -- -- -- -- -- -- -- -- Q7KQZ4 149 1.2e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF13912//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.10627 BP_3 1.00 0.35 430 557018159 XP_006009466.1 160 7.8e-09 PREDICTED: uncharacterized protein LOC102349681 isoform X1 [Latimeria chalumnae]>gi|557018161|ref|XP_006009467.1| PREDICTED: uncharacterized protein LOC102349681 isoform X2 [Latimeria chalumnae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10628 BP_3 8.00 0.71 838 91083455 XP_970663.1 537 2.9e-52 PREDICTED: uncharacterized protein LOC659245 [Tribolium castaneum]>gi|642923952|ref|XP_008193938.1| PREDICTED: uncharacterized protein LOC659245 [Tribolium castaneum]>gi|270007799|gb|EFA04247.1| hypothetical protein TcasGA2_TC014501 [Tribolium castaneum] 642923953 XM_965570.2 71 1.25291e-26 PREDICTED: Tribolium castaneum uncharacterized LOC659245 (LOC659245), transcript variant X2, mRNA -- -- -- -- P52302 256 4.6e-21 Protein lethal(3)malignant blood neoplasm 1 OS=Drosophila melanogaster GN=l(3)mbn PE=2 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.1063 BP_3 7.00 0.34 1290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10631 BP_3 27.64 3.35 690 665814372 XP_008555793.1 307 1.1e-25 PREDICTED: ankyrin repeat domain-containing protein 39 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- Q0P5B9 259 1.7e-21 Ankyrin repeat domain-containing protein 39 OS=Bos taurus GN=ANKRD39 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.1064 BP_3 1.00 0.57 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10644 BP_3 6.00 0.41 1004 821481342 XP_012403733.1 453 1.9e-42 PREDICTED: eukaryotic translation initiation factor 1 [Sarcophilus harrisii] 92443686 BC011740.1 1004 0 Homo sapiens mRNA similar to eukaryotic translation initiation factor 3, subunit 7 (zeta, 66/67kD) (cDNA clone IMAGE:3353208) K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 Q5E938 453 7.9e-44 Eukaryotic translation initiation factor 1 OS=Bos taurus GN=EIF1 PE=3 SV=1 PF01253 Translation initiation factor SUI1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.10646 BP_3 74.22 0.85 4482 688552709 XP_009299347.1 406 2.4e-36 PREDICTED: zinc finger protein OZF-like [Danio rerio]>gi|688552711|ref|XP_009299348.1| PREDICTED: zinc finger protein OZF-like [Danio rerio] -- -- -- -- -- -- -- -- -- Q8N184 409 4.5e-38 Zinc finger protein 567 OS=Homo sapiens GN=ZNF567 PE=1 SV=3 PF07975//PF05151//PF02146//PF13465//PF05485//PF16622//PF13912//PF01155//PF06397//PF00096//PF00569//PF06467//PF07776 TFIIH C1-like domain//Photosystem II reaction centre M protein (PsbM)//Sir2 family//Zinc-finger double domain//THAP domain//zinc-finger C2H2-type//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Desulfoferrodoxin, N-terminal domain//Zinc finger, C2H2 type//Zinc finger, ZZ type//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD) GO:0006281//GO:0015979//GO:0006464//GO:0019684 DNA repair//photosynthesis//cellular protein modification process//photosynthesis, light reaction GO:0016151//GO:0070403//GO:0046872//GO:0005506//GO:0003676//GO:0008270 nickel cation binding//NAD+ binding//metal ion binding//iron ion binding//nucleic acid binding//zinc ion binding GO:0005634//GO:0016021//GO:0009523 nucleus//integral component of membrane//photosystem II -- -- Cluster-8309.10648 BP_3 150.40 13.01 849 91081297 XP_968817.1 603 6.6e-60 PREDICTED: protein cornichon homolog 4 [Tribolium castaneum] 755947428 XM_011302162.1 60 1.65458e-20 PREDICTED: Fopius arisanus protein cornichon homolog 4 (LOC105264936), mRNA -- -- -- -- Q3T126 409 8.5e-39 Protein cornichon homolog 4 OS=Bos taurus GN=CNIH4 PE=2 SV=1 PF03311//PF02902 Cornichon protein//Ulp1 protease family, C-terminal catalytic domain GO:0006508//GO:0035556 proteolysis//intracellular signal transduction GO:0008234 cysteine-type peptidase activity GO:0016020 membrane KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.10649 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10651 BP_3 141.09 6.65 1314 642911443 XP_008199425.1 1224 1.0e-131 PREDICTED: hydroxymethylglutaryl-CoA lyase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01640 E4.1.3.4, HMGCL, hmgL hydroxymethylglutaryl-CoA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01640 D4A5C3 969 1.5e-103 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic OS=Rattus norvegicus GN=Hmgcll1 PE=1 SV=1 PF00682 HMGL-like -- -- GO:0003824 catalytic activity -- -- KOG2368 Hydroxymethylglutaryl-CoA lyase Cluster-8309.1066 BP_3 3.00 0.52 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10662 BP_3 83.00 2.16 2145 642916699 XP_008192238.1 1187 3.2e-127 PREDICTED: forkhead box protein F1-like [Tribolium castaneum]>gi|642916701|ref|XP_008192244.1| PREDICTED: forkhead box protein F1-like [Tribolium castaneum] 642916698 XM_008194016.1 456 0 PREDICTED: Tribolium castaneum forkhead box protein F1-like (LOC100142613), transcript variant X1, mRNA K09399 FOXF forkhead box protein F http://www.genome.jp/dbget-bin/www_bget?ko:K09399 O54743 446 1.1e-42 Forkhead box protein F2 OS=Mus musculus GN=Foxf2 PE=2 SV=2 PF00250//PF00879 Forkhead domain//Defensin propeptide GO:0006952//GO:0006355 defense response//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.10665 BP_3 1.00 0.82 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10666 BP_3 13.00 15.63 321 817068587 XP_012256239.1 231 3.4e-17 PREDICTED: uncharacterized protein LOC105686192 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q17015 203 2.5e-15 Cuticle protein OS=Anopheles gambiae GN=Ccp84Ab PE=2 SV=3 PF02530//PF00379 Porin subfamily//Insect cuticle protein GO:0006810 transport GO:0042302//GO:0015288 structural constituent of cuticle//porin activity GO:0016020 membrane -- -- Cluster-8309.10672 BP_3 41.26 0.48 4401 642928576 XP_008199963.1 3541 0.0e+00 PREDICTED: neural cell adhesion molecule 2 [Tribolium castaneum] 768424813 XM_011555074.1 65 1.47149e-22 PREDICTED: Plutella xylostella B-cell receptor CD22 (LOC105384795), mRNA -- -- -- -- O15394 292 1.6e-24 Neural cell adhesion molecule 2 OS=Homo sapiens GN=NCAM2 PE=1 SV=2 PF05790//PF06663//PF13895//PF00041 Immunoglobulin C2-set domain//Protein of unknown function (DUF1170)//Immunoglobulin domain//Fibronectin type III domain GO:0009966//GO:0007155 regulation of signal transduction//cell adhesion GO:0005515 protein binding GO:0016020//GO:0016021//GO:0005737 membrane//integral component of membrane//cytoplasm -- -- Cluster-8309.10675 BP_3 44.61 3.17 969 642922841 XP_001813804.2 546 3.1e-53 PREDICTED: uncharacterized protein LOC100141768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05297//PF03694 Herpesvirus latent membrane protein 1 (LMP1)//Erg28 like protein GO:0019087 transformation of host cell by virus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.10676 BP_3 10.34 0.58 1147 642922841 XP_001813804.2 351 1.5e-30 PREDICTED: uncharacterized protein LOC100141768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03694 Erg28 like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.10680 BP_3 5.00 0.35 971 498938378 XP_004520892.1 247 1.4e-18 PREDICTED: density-regulated protein homolog [Ceratitis capitata] 389609388 AK401684.1 99 3.97457e-42 Papilio xuthus mRNA for similar to CG9099, complete cds, sequence id: Px-1124 -- -- -- -- Q9VX98 239 5.0e-19 Density-regulated protein homolog OS=Drosophila melanogaster GN=DENR PE=1 SV=3 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG3239 Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.10681 BP_3 27.00 0.71 2122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07677 A-macroglobulin receptor -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.10684 BP_3 22.06 4.37 535 642928075 XP_008200145.1 328 3.2e-28 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270010867|gb|EFA07315.1| hypothetical protein TcasGA2_TC015908 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 276 1.4e-23 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.10688 BP_3 19.56 0.36 2904 189233854 XP_972406.2 1860 3.9e-205 PREDICTED: uncharacterized protein LOC661132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03220 Tombusvirus P19 core protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.10690 BP_3 6.00 0.56 811 857977027 CEO97135.1 277 4.0e-22 hypothetical protein PBRA_005739 [Plasmodiophora brassicae] 768311759 CP010987.1 664 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- Q91VC9 248 3.8e-20 Growth hormone-inducible transmembrane protein OS=Mus musculus GN=Ghitm PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10691 BP_3 3.00 0.67 508 -- -- -- -- -- 768311759 CP010987.1 505 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10696 BP_3 5.00 0.76 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10698 BP_3 67.73 0.43 7904 549084993 BAO00914.1 416 3.0e-37 broad-complex [Psacothea hilaris] 549084992 AB857715.1 205 3.96164e-100 Psacothea hilaris PhBR-C_Z1 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q24206 345 2.1e-30 Broad-complex core protein isoform 6 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF02892//PF03854//PF01363//PF13912//PF16622//PF13465//PF00096//PF00130 BED zinc finger//P-11 zinc finger//FYVE zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0046872//GO:0003677//GO:0008270//GO:0003723 metal ion binding//DNA binding//zinc ion binding//RNA binding -- -- -- -- Cluster-8309.10712 BP_3 153679.54 9566.84 1066 478255888 ENN76095.1 169 1.7e-09 hypothetical protein YQE_07378, partial [Dendroctonus ponderosae]>gi|478266978|gb|ENN82965.1| hypothetical protein YQE_00671, partial [Dendroctonus ponderosae]>gi|478269605|gb|ENN83363.1| hypothetical protein YQE_00278, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P26967 151 8.8e-09 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10713 BP_3 10.88 0.57 1207 91085589 XP_968685.1 428 1.8e-39 PREDICTED: selenide, water dikinase [Tribolium castaneum]>gi|270010074|gb|EFA06522.1| hypothetical protein TcasGA2_TC009425 [Tribolium castaneum] -- -- -- -- -- K01008 selD, SEPHS selenide, water dikinase http://www.genome.jp/dbget-bin/www_bget?ko:K01008 O18373 266 4.6e-22 Selenide, water dikinase OS=Drosophila melanogaster GN=SelD PE=2 SV=1 -- -- GO:0008152 metabolic process GO:0005524//GO:0004756 ATP binding//selenide, water dikinase activity -- -- -- -- Cluster-8309.10716 BP_3 41.99 0.69 3223 189237912 XP_969631.2 2893 0.0e+00 PREDICTED: histone acetyltransferase KAT2A [Tribolium castaneum]>gi|270008022|gb|EFA04470.1| hypothetical protein TcasGA2_TC014774 [Tribolium castaneum] -- -- -- -- -- K06062 PCAF, KAT2, GCN5 histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06062 Q9JHD2 1837 8.4e-204 Histone acetyltransferase KAT2A OS=Mus musculus GN=Kat2a PE=1 SV=2 PF13508//PF06472//PF00583//PF13673//PF00439//PF06466 Acetyltransferase (GNAT) domain//ABC transporter transmembrane region 2//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Bromodomain//PCAF (P300/CBP-associated factor) N-terminal domain GO:0006355//GO:0055085//GO:0016573//GO:0006810//GO:0042967 regulation of transcription, DNA-templated//transmembrane transport//histone acetylation//transport//acyl-carrier-protein biosynthetic process GO:0042626//GO:0005524//GO:0004402//GO:0005515//GO:0008080 ATPase activity, coupled to transmembrane movement of substances//ATP binding//histone acetyltransferase activity//protein binding//N-acetyltransferase activity GO:0000123//GO:0005634//GO:0016021 histone acetyltransferase complex//nucleus//integral component of membrane KOG1472 Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins Cluster-8309.10717 BP_3 1.94 0.48 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10724 BP_3 9.00 1.03 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10726 BP_3 3.00 0.79 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10727 BP_3 32.18 0.58 2964 546674875 ERL86161.1 1797 8.1e-198 hypothetical protein D910_03574 [Dendroctonus ponderosae] -- -- -- -- -- K12796 ERBB2IP, ERBIN erbb2-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12796 Q9V780 420 1.6e-39 Protein lap1 OS=Drosophila melanogaster GN=Lap1 PE=2 SV=1 PF13516//PF13855//PF13180//PF00560//PF00595 Leucine Rich repeat//Leucine rich repeat//PDZ domain//Leucine Rich Repeat//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.10729 BP_3 14.83 0.54 1626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03521 Kv2 voltage-gated K+ channel GO:0006813 potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0008076 voltage-gated potassium channel complex -- -- Cluster-8309.10731 BP_3 5.00 1.04 523 769849730 XP_011636256.1 202 1.3e-13 PREDICTED: polyubiquitin-B isoform X1 [Pogonomyrmex barbatus] 302415544 XM_003005558.1 514 0 Verticillium albo-atrum VaMs.102 ubiquitin-40S ribosomal protein S31 fusion protein, partial mRNA K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 P0CG54 202 5.3e-15 Polyubiquitin-B OS=Cavia porcellus GN=UBB PE=2 SV=1 PF00240//PF01599 Ubiquitin family//Ribosomal protein S27a GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840 ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.10735 BP_3 47.33 1.19 2202 546682805 ERL92694.1 1490 2.4e-162 hypothetical protein D910_10005 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01939 737 2.0e-76 Protein misato OS=Drosophila melanogaster GN=mst PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2530 Members of tubulin/FtsZ family Cluster-8309.10742 BP_3 59.00 5.48 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06610 L-alanine exporter -- -- GO:0034639 L-amino acid efflux transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.10745 BP_3 36.29 0.87 2293 7155 CAA43305.1 435 5.4e-40 transposase [Drosophila bifasciata] -- -- -- -- -- -- -- -- -- Q7M3K2 430 8.4e-41 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF02689//PF05531//PF04977 Helicase//Nucleopolyhedrovirus P10 protein//Septum formation initiator GO:0007049 cell cycle GO:0005524//GO:0004386 ATP binding//helicase activity GO:0019028 viral capsid -- -- Cluster-8309.1075 BP_3 10.00 0.83 871 357380454 3J0L 860 1.1e-89 Chain J, Core Of Mammalian 80s Pre-Ribosome In Complex With Trnas Fitted To A 9.8a Cryo-Em Map: Classic Pre State 1>gi|357380525|pdb|3J0Q|J Chain J, Core Of Mammalian 80s Pre-Ribosome In Complex With Trnas Fitted To A 10.6a Cryo-Em Map: Rotated Pre State 2 697072799 XM_009652886.1 817 0 Verticillium dahliae VdLs.17 60S ribosomal protein L10-B mRNA K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 Q09127 888 2.5e-94 60S ribosomal protein L10-A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl1001 PE=2 SV=2 PF08138//PF00252 Sex peptide (SP) family//Ribosomal protein L16p/L10e GO:0042254//GO:0046008//GO:0006412//GO:0007165 ribosome biogenesis//regulation of female receptivity, post-mating//translation//signal transduction GO:0003735//GO:0005179 structural constituent of ribosome//hormone activity GO:0005576//GO:0005840 extracellular region//ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.10751 BP_3 11.00 0.88 893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10753 BP_3 331.92 8.14 2258 642936737 XP_008198559.1 541 2.7e-52 PREDICTED: kinetochore protein NDC80 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4X5 214 9.2e-16 Kinetochore protein NDC80 homolog OS=Xenopus tropicalis GN=ndc80 PE=2 SV=1 PF00765//PF00170//PF05791//PF03836//PF00700 Autoinducer synthase//bZIP transcription factor//Bacillus haemolytic enterotoxin (HBL)//RasGAP C-terminus//Bacterial flagellin C-terminal helical region GO:0006355//GO:0007264//GO:0009405//GO:0071973 regulation of transcription, DNA-templated//small GTPase mediated signal transduction//pathogenesis//bacterial-type flagellum-dependent cell motility GO:0043565//GO:0003700//GO:0005096//GO:0016740//GO:0005198 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//GTPase activator activity//transferase activity//structural molecule activity GO:0016020//GO:0005667 membrane//transcription factor complex -- -- Cluster-8309.10758 BP_3 93.43 1.86 2711 357621647 EHJ73416.1 189 2.1e-11 putative pol-like protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00075//PF02723 RNase H//Non-structural protein NS3/Small envelope protein E GO:0051252 regulation of RNA metabolic process GO:0004523//GO:0003676 RNA-DNA hybrid ribonuclease activity//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.10759 BP_3 178.34 3.31 2892 642930067 XP_008196236.1 3292 0.0e+00 PREDICTED: nephrin-like [Tribolium castaneum] 642930066 XM_008198014.1 458 0 PREDICTED: Tribolium castaneum nephrin-like (LOC663423), mRNA -- -- -- -- A2AJ76 208 5.9e-15 Hemicentin-2 OS=Mus musculus GN=Hmcn2 PE=2 SV=1 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10761 BP_3 87.39 1.94 2464 270016811 EFA13257.1 202 6.0e-13 hypothetical protein TcasGA2_TC001527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10762 BP_3 1.00 0.73 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10763 BP_3 156.00 5.10 1766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10764 BP_3 4.00 0.75 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10767 BP_3 1.00 0.46 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10769 BP_3 14.00 0.31 2444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10771 BP_3 16.03 0.49 1864 478257213 ENN77376.1 1863 1.1e-205 hypothetical protein YQE_06201, partial [Dendroctonus ponderosae] -- -- -- -- -- K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q6TGS6 1785 5.2e-198 Tyrosine--tRNA ligase, cytoplasmic OS=Danio rerio GN=yars PE=2 SV=2 PF08039//PF00579//PF01588 Mitochondrial proteolipid//tRNA synthetases class I (W and Y)//Putative tRNA binding domain GO:0006418 tRNA aminoacylation for protein translation GO:0000049//GO:0004812//GO:0000166//GO:0005524 tRNA binding//aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding GO:0005739 mitochondrion KOG2144 Tyrosyl-tRNA synthetase, cytoplasmic Cluster-8309.10772 BP_3 242.90 4.09 3157 189237912 XP_969631.2 2893 0.0e+00 PREDICTED: histone acetyltransferase KAT2A [Tribolium castaneum]>gi|270008022|gb|EFA04470.1| hypothetical protein TcasGA2_TC014774 [Tribolium castaneum] -- -- -- -- -- K06062 PCAF, KAT2, GCN5 histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06062 Q9JHD2 1837 8.2e-204 Histone acetyltransferase KAT2A OS=Mus musculus GN=Kat2a PE=1 SV=2 PF13673//PF00583//PF06472//PF13508//PF00439//PF06466 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//ABC transporter transmembrane region 2//Acetyltransferase (GNAT) domain//Bromodomain//PCAF (P300/CBP-associated factor) N-terminal domain GO:0006355//GO:0055085//GO:0016573//GO:0006810//GO:0042967 regulation of transcription, DNA-templated//transmembrane transport//histone acetylation//transport//acyl-carrier-protein biosynthetic process GO:0042626//GO:0005524//GO:0008080//GO:0004402//GO:0005515 ATPase activity, coupled to transmembrane movement of substances//ATP binding//N-acetyltransferase activity//histone acetyltransferase activity//protein binding GO:0000123//GO:0005634//GO:0016021 histone acetyltransferase complex//nucleus//integral component of membrane KOG1472 Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins Cluster-8309.10776 BP_3 170.49 1.98 4439 642923595 XP_008193574.1 1536 2.2e-167 PREDICTED: multidrug resistance-associated protein 4-like [Tribolium castaneum] 615443230 XM_007592307.1 39 4.21544e-08 Colletotrichum fioriniae PJ7 ABC transporter mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 929 2.2e-98 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF08477//PF01926//PF13304//PF00664//PF00004//PF03193//PF00005//PF02367//PF01637//PF04542//PF00270 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Archaeal ATPase//Sigma-70 region 2//DEAD/DEAH box helicase GO:0006355//GO:0055085//GO:0006810//GO:0002949//GO:0006352//GO:0007264 regulation of transcription, DNA-templated//transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification//DNA-templated transcription, initiation//small GTPase mediated signal transduction GO:0016887//GO:0042626//GO:0003700//GO:0005524//GO:0003924//GO:0003676//GO:0016987//GO:0005525//GO:0003677 ATPase activity//ATPase activity, coupled to transmembrane movement of substances//transcription factor activity, sequence-specific DNA binding//ATP binding//GTPase activity//nucleic acid binding//sigma factor activity//GTP binding//DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.10777 BP_3 1706.30 21.78 4067 270007694 EFA04142.1 2469 1.3e-275 hypothetical protein TcasGA2_TC014386 [Tribolium castaneum] 615443230 XM_007592307.1 39 3.85929e-08 Colletotrichum fioriniae PJ7 ABC transporter mRNA -- -- -- -- O15439 1626 3.1e-179 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF01443//PF00437//PF00005//PF03266//PF03193//PF01637//PF00006//PF00910//PF08477//PF00664//PF13304//PF01926//PF00004//PF02367//PF04542//PF00931 Viral (Superfamily 1) RNA helicase//Type II/IV secretion system protein//ABC transporter//NTPase//Protein of unknown function, DUF258//Archaeal ATPase//ATP synthase alpha/beta family, nucleotide-binding domain//RNA helicase//Ras of Complex, Roc, domain of DAPkinase//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Sigma-70 region 2//NB-ARC domain GO:0007264//GO:0006352//GO:0002949//GO:0006355//GO:0006810//GO:0055085 small GTPase mediated signal transduction//DNA-templated transcription, initiation//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//transport//transmembrane transport GO:0003724//GO:0005525//GO:0016987//GO:0043531//GO:0003723//GO:0003677//GO:0003700//GO:0042626//GO:0016887//GO:0003924//GO:0005524//GO:0098519 RNA helicase activity//GTP binding//sigma factor activity//ADP binding//RNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-8309.10778 BP_3 61.60 0.72 4440 642923595 XP_008193574.1 1294 2.6e-139 PREDICTED: multidrug resistance-associated protein 4-like [Tribolium castaneum] 615443230 XM_007592307.1 39 4.2164e-08 Colletotrichum fioriniae PJ7 ABC transporter mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 901 4.0e-95 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF02367//PF01637//PF03193//PF00005//PF04542//PF00270//PF01926//PF13304//PF00664//PF08477//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//Sigma-70 region 2//DEAD/DEAH box helicase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase//ATPase family associated with various cellular activities (AAA) GO:0006355//GO:0006810//GO:0055085//GO:0006352//GO:0007264//GO:0002949 regulation of transcription, DNA-templated//transport//transmembrane transport//DNA-templated transcription, initiation//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification GO:0042626//GO:0003700//GO:0016887//GO:0003924//GO:0005524//GO:0003676//GO:0016987//GO:0005525//GO:0003677 ATPase activity, coupled to transmembrane movement of substances//transcription factor activity, sequence-specific DNA binding//ATPase activity//GTPase activity//ATP binding//nucleic acid binding//sigma factor activity//GTP binding//DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.10779 BP_3 98.61 1.22 4197 189237499 XP_971802.2 3057 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007691|gb|EFA04139.1| hypothetical protein TcasGA2_TC014383 [Tribolium castaneum] 615443230 XM_007592307.1 39 3.98375e-08 Colletotrichum fioriniae PJ7 ABC transporter mRNA -- -- -- -- O15439 1885 3.0e-209 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00931//PF00910//PF04542//PF02367//PF01637//PF03266//PF03193//PF00005//PF00437//PF00004//PF01926//PF13304//PF00664//PF08477 NB-ARC domain//RNA helicase//Sigma-70 region 2//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Archaeal ATPase//NTPase//Protein of unknown function, DUF258//ABC transporter//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase GO:0006352//GO:0007264//GO:0002949//GO:0006355//GO:0006810//GO:0055085 DNA-templated transcription, initiation//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//transport//transmembrane transport GO:0003724//GO:0017111//GO:0005525//GO:0016987//GO:0043531//GO:0003723//GO:0003677//GO:0003700//GO:0042626//GO:0016887//GO:0003924//GO:0005524//GO:0098519 RNA helicase activity//nucleoside-triphosphatase activity//GTP binding//sigma factor activity//ADP binding//RNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-8309.10784 BP_3 4.00 0.45 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1079 BP_3 11.96 0.36 1874 189238680 XP_966563.2 1373 7.5e-149 PREDICTED: cytochrome P450 4C1-like [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1035 4.8e-111 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.10791 BP_3 73.23 1.72 2344 190702371 ACE75264.1 1009 1.5e-106 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175//PF01363//PF00096//PF08685 DNA polymerase type B, organellar and viral//FYVE zinc finger//Zinc finger, C2H2 type//GON domain GO:0006260 DNA replication GO:0046872//GO:0000166//GO:0008270//GO:0008408//GO:0003887//GO:0004222//GO:0003677 metal ion binding//nucleotide binding//zinc ion binding//3'-5' exonuclease activity//DNA-directed DNA polymerase activity//metalloendopeptidase activity//DNA binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.10794 BP_3 367.98 36.93 772 270002480 EEZ98927.1 350 1.3e-30 hypothetical protein TcasGA2_TC004547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 254 7.2e-21 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.10795 BP_3 1.00 5.19 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10797 BP_3 1897.02 37.69 2718 642931247 XP_008196499.1 1520 9.8e-166 PREDICTED: protein yellow [Tribolium castaneum]>gi|270012127|gb|EFA08575.1| hypothetical protein TcasGA2_TC006230 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI23 678 1.7e-69 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10798 BP_3 13.81 0.54 1515 546680841 ERL91040.1 485 5.7e-46 hypothetical protein D910_08382 [Dendroctonus ponderosae] 195134259 XM_002011519.1 48 1.40741e-13 Drosophila mojavensis GI11033 (Dmoj\GI11033), mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.108 BP_3 17.35 3.94 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10805 BP_3 1.00 1.08 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10807 BP_3 154.80 1.55 5104 817074162 XP_012259260.1 369 5.4e-32 PREDICTED: uncharacterized protein LOC105687895 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10808 BP_3 4.00 0.67 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10816 BP_3 7.26 0.95 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF01082 THAP domain//Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0055114 oxidation-reduction process GO:0016715//GO:0004497//GO:0003676//GO:0005507 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity//nucleic acid binding//copper ion binding -- -- -- -- Cluster-8309.10817 BP_3 9.43 0.33 1669 478250642 ENN71134.1 363 8.8e-32 hypothetical protein YQE_12065, partial [Dendroctonus ponderosae]>gi|546674775|gb|ERL86072.1| hypothetical protein D910_03486 [Dendroctonus ponderosae] -- -- -- -- -- K03028 PSMD2, RPN1 26S proteasome regulatory subunit N1 http://www.genome.jp/dbget-bin/www_bget?ko:K03028 P56701 224 4.7e-17 26S proteasome non-ATPase regulatory subunit 2 OS=Bos taurus GN=PSMD2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2 Cluster-8309.1082 BP_3 1.00 0.88 340 189234826 XP_970712.2 252 1.3e-19 PREDICTED: Hermansky-Pudlak syndrome 1 protein homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10823 BP_3 75.54 0.93 4204 270010030 EFA06478.1 760 2.0e-77 hypothetical protein TcasGA2_TC009372 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10824 BP_3 194.27 2.51 4029 642926929 XP_008195061.1 1542 4.1e-168 PREDICTED: uncharacterized protein LOC100141786 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10827 BP_3 89.70 2.03 2417 780693755 XP_011700257.1 1127 3.3e-120 PREDICTED: uncharacterized protein LOC105457338 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04574//PF03175 Protein of unknown function (DUF592)//DNA polymerase type B, organellar and viral GO:0006342//GO:0006476//GO:0006355//GO:0006260//GO:0006807 chromatin silencing//protein deacetylation//regulation of transcription, DNA-templated//DNA replication//nitrogen compound metabolic process GO:0003677//GO:0016811//GO:0051287//GO:0017136//GO:0003887//GO:0008270//GO:0000166//GO:0008408 DNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//NAD binding//NAD-dependent histone deacetylase activity//DNA-directed DNA polymerase activity//zinc ion binding//nucleotide binding//3'-5' exonuclease activity GO:0042575//GO:0000118 DNA polymerase complex//histone deacetylase complex -- -- Cluster-8309.1083 BP_3 12.00 2.58 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10830 BP_3 3.00 0.35 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10835 BP_3 46.00 0.63 3800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10836 BP_3 12.97 1.52 703 758213802 AJO62214.1 272 1.3e-21 chemosensory protein CSP8 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q27377 181 1.9e-12 Putative odorant-binding protein A10 OS=Drosophila melanogaster GN=a10 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10837 BP_3 1.00 0.46 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00537 Scorpion toxin-like domain GO:0006810 transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.10840 BP_3 5.00 0.67 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10843 BP_3 373.95 5.61 3507 817324046 XP_012332723.1 243 1.5e-17 PREDICTED: zinc finger protein 808, partial [Aotus nancymaae] 642918103 XM_008195805.1 309 2.68767e-158 PREDICTED: Tribolium castaneum Krueppel-like factor 6 (LOC103313193), transcript variant X2, mRNA K09206 KLF5 krueppel-like factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09206 Q5VIY5 232 1.2e-17 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF15060//PF00471//PF00096//PF13465 C2H2-type zinc finger//Differentiation and proliferation regulator//Ribosomal protein L33//Zinc finger, C2H2 type//Zinc-finger double domain GO:0042254//GO:0030154//GO:0006412//GO:0007275 ribosome biogenesis//cell differentiation//translation//multicellular organismal development GO:0046872//GO:0003735 metal ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.10844 BP_3 1077.00 31.02 1965 478263043 ENN81443.1 1545 9.0e-169 hypothetical protein YQE_02136, partial [Dendroctonus ponderosae] -- -- -- -- -- K16674 FJX1 four-jointed box protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16674 P54360 935 2.0e-99 Extracellular serine/threonine protein kinase four-jointed OS=Drosophila melanogaster GN=fj PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10845 BP_3 80.67 2.07 2174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.10846 BP_3 41.48 4.93 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00569 Zinc finger, ZZ type -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.10850 BP_3 36.91 0.69 2868 91079146 XP_966535.1 346 1.4e-29 PREDICTED: ankyrin repeat domain-containing protein 49 [Tribolium castaneum]>gi|270004231|gb|EFA00679.1| hypothetical protein TcasGA2_TC003556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VE42 245 3.0e-19 Ankyrin repeat domain-containing protein 49 OS=Mus musculus GN=Ankrd49 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.10854 BP_3 2.00 0.34 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1086 BP_3 6.00 0.64 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10866 BP_3 174.87 12.73 954 91084083 XP_966773.1 515 1.2e-49 PREDICTED: uncharacterized protein LOC656652 [Tribolium castaneum]>gi|270008009|gb|EFA04457.1| hypothetical protein TcasGA2_TC014761 [Tribolium castaneum] 462298889 APGK01051512.1 56 3.12541e-18 Dendroctonus ponderosae Seq01051522, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10869 BP_3 46.49 2.05 1383 91078614 XP_967493.1 1057 2.4e-112 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 38 4.6432e-08 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 O43752 526 3.7e-52 Syntaxin-6 OS=Homo sapiens GN=STX6 PE=1 SV=1 PF05478//PF05739//PF00957//PF00523 Prominin//SNARE domain//Synaptobrevin//Fusion glycoprotein F0 GO:0016192//GO:0006948 vesicle-mediated transport//induction by virus of host cell-cell fusion GO:0005515 protein binding GO:0016021 integral component of membrane KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.10873 BP_3 143.00 10.71 935 91089477 XP_969208.1 235 3.4e-17 PREDICTED: zinc finger HIT domain-containing protein 3 [Tribolium castaneum]>gi|270012577|gb|EFA09025.1| hypothetical protein TcasGA2_TC006734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQK1 149 1.3e-08 Zinc finger HIT domain-containing protein 3 OS=Mus musculus GN=Znhit3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10874 BP_3 3.00 0.50 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10878 BP_3 15.10 0.67 1374 642930300 XP_008196336.1 534 1.1e-51 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10883 BP_3 167.46 1.47 5779 642934786 XP_008197807.1 453 1.1e-41 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270013455|gb|EFA09903.1| hypothetical protein TcasGA2_TC012053 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10884 BP_3 12.00 2.84 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10893 BP_3 24.45 0.39 3325 189234553 XP_973928.2 1591 7.0e-174 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] 571543566 XM_006559674.1 150 6.21724e-70 PREDICTED: Apis mellifera putative homeodomain transcription factor-like (LOC551885), mRNA -- -- -- -- Q9V9A8 918 3.2e-97 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.10894 BP_3 22.00 0.47 2533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10896 BP_3 210.95 6.95 1755 91094191 XP_971121.1 2131 9.0e-237 PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|642928139|ref|XP_008200172.1| PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|270010854|gb|EFA07302.1| hypothetical protein TcasGA2_TC015892 [Tribolium castaneum] -- -- -- -- -- K03144 TFIIH4, GTF2H4, TFB2 transcription initiation factor TFIIH subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03144 O70422 1220 1.6e-132 General transcription factor IIH subunit 4 OS=Mus musculus GN=Gtf2h4 PE=2 SV=1 PF03849 Transcription factor Tfb2 GO:0006289//GO:0006281//GO:0006355 nucleotide-excision repair//DNA repair//regulation of transcription, DNA-templated GO:0004003 ATP-dependent DNA helicase activity GO:0000439//GO:0005634//GO:0005657 core TFIIH complex//nucleus//replication fork KOG3471 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 Cluster-8309.10897 BP_3 22.50 0.49 2510 91094191 XP_971121.1 1078 1.6e-114 PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|642928139|ref|XP_008200172.1| PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|270010854|gb|EFA07302.1| hypothetical protein TcasGA2_TC015892 [Tribolium castaneum] -- -- -- -- -- K03144 TFIIH4, GTF2H4, TFB2 transcription initiation factor TFIIH subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03144 O70422 584 1.3e-58 General transcription factor IIH subunit 4 OS=Mus musculus GN=Gtf2h4 PE=2 SV=1 PF03849 Transcription factor Tfb2 GO:0006281//GO:0006289//GO:0006355 DNA repair//nucleotide-excision repair//regulation of transcription, DNA-templated GO:0004003 ATP-dependent DNA helicase activity GO:0000439//GO:0005634//GO:0005657 core TFIIH complex//nucleus//replication fork KOG3471 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 Cluster-8309.10899 BP_3 14.91 0.35 2362 91094191 XP_971121.1 1078 1.5e-114 PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|642928139|ref|XP_008200172.1| PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|270010854|gb|EFA07302.1| hypothetical protein TcasGA2_TC015892 [Tribolium castaneum] -- -- -- -- -- K03144 TFIIH4, GTF2H4, TFB2 transcription initiation factor TFIIH subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03144 O70422 639 5.1e-65 General transcription factor IIH subunit 4 OS=Mus musculus GN=Gtf2h4 PE=2 SV=1 PF03849 Transcription factor Tfb2 GO:0006289//GO:0006281//GO:0006355 nucleotide-excision repair//DNA repair//regulation of transcription, DNA-templated GO:0004003 ATP-dependent DNA helicase activity GO:0000439//GO:0005634//GO:0005657 core TFIIH complex//nucleus//replication fork KOG3471 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 Cluster-8309.1090 BP_3 7.00 0.32 1361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10901 BP_3 21.00 1.90 825 -- -- -- -- -- 768311753 CP010981.1 801 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF01213//PF02438//PF02209 Adenylate cyclase associated (CAP) N terminal//Late 100kD protein//Villin headpiece domain GO:0007010//GO:0019060 cytoskeleton organization//intracellular transport of viral protein in host cell GO:0003779 actin binding -- -- -- -- Cluster-8309.10903 BP_3 1201.04 24.36 2668 300303952 ADJ97385.1 1183 1.2e-126 star [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42519 539 2.3e-53 Protein Star OS=Drosophila melanogaster GN=S PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10908 BP_3 3.00 0.46 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10909 BP_3 2.00 0.40 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1091 BP_3 18.00 0.47 2155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10910 BP_3 50.46 1.52 1887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05969 Photosystem II complex subunit Ycf12 GO:0015979 photosynthesis -- -- GO:0009523//GO:0016021 photosystem II//integral component of membrane -- -- Cluster-8309.10916 BP_3 6.00 0.69 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1092 BP_3 15.30 0.43 2002 815896315 XP_012246840.1 705 2.3e-71 PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896317|ref|XP_012246847.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896319|ref|XP_012246857.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q9WUW9 404 7.6e-38 Sulfotransferase 1C2A OS=Rattus norvegicus GN=Sult1c2a PE=2 SV=2 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.10927 BP_3 3.00 0.41 645 662215753 XP_008481775.1 413 5.4e-38 PREDICTED: uncharacterized protein LOC103518486 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P04323 292 2.4e-25 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.10930 BP_3 9.32 0.33 1635 642918952 XP_974118.3 1332 3.7e-144 PREDICTED: protein king tubby [Tribolium castaneum]>gi|270005704|gb|EFA02152.1| hypothetical protein TcasGA2_TC007804 [Tribolium castaneum] 820849454 XM_003693782.2 230 1.02102e-114 PREDICTED: Apis florea protein king tubby (LOC100866222), mRNA -- -- -- -- Q7PZK5 976 2.9e-104 Protein king tubby OS=Anopheles gambiae GN=king-tubby PE=3 SV=4 -- -- -- -- -- -- -- -- KOG2502 Tub family proteins Cluster-8309.10936 BP_3 53.00 0.85 3297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10939 BP_3 6.00 0.31 1235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1094 BP_3 43168.10 3204.67 941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03843//PF04114//PF04513 Outer membrane lipoprotein Slp family//Gaa1-like, GPI transamidase component//Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0042765//GO:0019031//GO:0019028//GO:0016021//GO:0019867 GPI-anchor transamidase complex//viral envelope//viral capsid//integral component of membrane//outer membrane -- -- Cluster-8309.10940 BP_3 623.13 11.44 2918 270008647 EFA05095.1 800 3.3e-82 hypothetical protein TcasGA2_TC015194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VBV3 286 5.4e-24 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10944 BP_3 15.87 0.32 2689 91090272 XP_970617.1 1298 5.4e-140 PREDICTED: nitrogen permease regulator 3-like protein [Tribolium castaneum]>gi|270013442|gb|EFA09890.1| hypothetical protein TcasGA2_TC012039 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUB4 676 2.9e-69 Nitrogen permease regulator 3-like protein OS=Drosophila melanogaster GN=CG8783 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3830 Uncharacterized conserved protein Cluster-8309.10945 BP_3 71.18 1.44 2674 91090272 XP_970617.1 1479 5.5e-161 PREDICTED: nitrogen permease regulator 3-like protein [Tribolium castaneum]>gi|270013442|gb|EFA09890.1| hypothetical protein TcasGA2_TC012039 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUB4 776 7.4e-81 Nitrogen permease regulator 3-like protein OS=Drosophila melanogaster GN=CG8783 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3830 Uncharacterized conserved protein Cluster-8309.10946 BP_3 1.34 0.67 387 383862633 XP_003706788.1 274 4.2e-22 PREDICTED: uncharacterized protein LOC100881105 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10952 BP_3 468.90 3.59 6585 189234173 XP_968418.2 1427 1.4e-154 PREDICTED: RNA-binding protein Musashi homolog 2 isoform X2 [Tribolium castaneum] 642912293 XM_963325.3 503 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog 2 (LOC656824), transcript variant X2, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q96DH6 622 1.3e-62 RNA-binding protein Musashi homolog 2 OS=Homo sapiens GN=MSI2 PE=1 SV=1 PF00076//PF01692//PF16367//PF01213//PF01371//PF05014//PF08777//PF03852 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Paramyxovirus non-structural protein C//RNA recognition motif//Adenylate cyclase associated (CAP) N terminal//Trp repressor protein//Nucleoside 2-deoxyribosyltransferase//RNA binding motif//DNA mismatch endonuclease Vsr GO:0006355//GO:0006206//GO:0030683//GO:0007010//GO:0009159//GO:0006298 regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process//evasion or tolerance by virus of host immune response//cytoskeleton organization//deoxyribonucleoside monophosphate catabolic process//mismatch repair GO:0003700//GO:0003676//GO:0070694//GO:0003779//GO:0050144//GO:0004519//GO:0003723 transcription factor activity, sequence-specific DNA binding//nucleic acid binding//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//actin binding//nucleoside deoxyribosyltransferase activity//endonuclease activity//RNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.10955 BP_3 569.37 9.90 3065 642924498 XP_008194320.1 2193 1.0e-243 PREDICTED: probable nuclear hormone receptor HR38 [Tribolium castaneum] 15706339 AB057767.1 38 1.04301e-07 Ciona savignyi Cs-NR1 mRNA for nuclear receptor 1, complete cds K08558 NR4A2, NURR1 nuclear receptor subfamily 4 group A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08558 P49869 1261 4.9e-137 Probable nuclear hormone receptor HR38 OS=Drosophila melanogaster GN=Hr38 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4217 Nuclear receptors of the nerve growth factor-induced protein B type Cluster-8309.10957 BP_3 21.07 0.57 2067 270008607 EFA05055.1 374 5.8e-33 hypothetical protein TcasGA2_TC015150 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08367 Peptidase M16C associated GO:0006508 proteolysis -- -- -- -- -- -- Cluster-8309.10964 BP_3 47.00 3.73 899 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10970 BP_3 470.34 7.07 3499 642914820 XP_967881.3 1233 2.4e-132 PREDICTED: uncharacterized protein LOC656247 [Tribolium castaneum] 642914819 XM_962788.3 195 6.31865e-95 PREDICTED: Tribolium castaneum uncharacterized LOC656247 (LOC656247), mRNA -- -- -- -- P17789 361 1.3e-32 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF00215//PF02954//PF00126//PF10414//PF01381 BTB/POZ domain//Orotidine 5'-phosphate decarboxylase / HUMPS family//Bacterial regulatory protein, Fis family//Bacterial regulatory helix-turn-helix protein, lysR family//Sirohaem synthase dimerisation region//Helix-turn-helix GO:0006207//GO:0055114//GO:0006779//GO:0006355//GO:0006206 'de novo' pyrimidine nucleobase biosynthetic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0005515//GO:0003700//GO:0043565//GO:0004590 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//orotidine-5'-phosphate decarboxylase activity GO:0005667 transcription factor complex -- -- Cluster-8309.10974 BP_3 283.09 4.14 3587 817058456 XP_012250690.1 951 1.2e-99 PREDICTED: uncharacterized protein LOC105682992 isoform X3 [Athalia rosae]>gi|817058458|ref|XP_012250691.1| PREDICTED: uncharacterized protein LOC105682992 isoform X3 [Athalia rosae]>gi|817058460|ref|XP_012250692.1| PREDICTED: uncharacterized protein LOC105682992 isoform X3 [Athalia rosae] 642914678 XM_008192090.1 169 1.84011e-80 PREDICTED: Tribolium castaneum longitudinals lacking protein-like (LOC663115), mRNA -- -- -- -- P17789 361 1.3e-32 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00215//PF00651//PF10414//PF02954 Orotidine 5'-phosphate decarboxylase / HUMPS family//BTB/POZ domain//Sirohaem synthase dimerisation region//Bacterial regulatory protein, Fis family GO:0006779//GO:0055114//GO:0006206//GO:0006207 porphyrin-containing compound biosynthetic process//oxidation-reduction process//pyrimidine nucleobase metabolic process//'de novo' pyrimidine nucleobase biosynthetic process GO:0005515//GO:0004590//GO:0043565 protein binding//orotidine-5'-phosphate decarboxylase activity//sequence-specific DNA binding -- -- -- -- Cluster-8309.10978 BP_3 173.26 3.36 2774 189233854 XP_972406.2 1888 2.1e-208 PREDICTED: uncharacterized protein LOC661132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03220 Tombusvirus P19 core protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.10979 BP_3 1482.17 28.61 2789 189233854 XP_972406.2 1893 5.7e-209 PREDICTED: uncharacterized protein LOC661132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03220 Tombusvirus P19 core protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.1098 BP_3 16.96 1.13 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10983 BP_3 32.40 1.60 1266 357623407 EHJ74574.1 365 3.9e-32 dihydrouridine synthase domain containing protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01159//PF02944 Ribosomal protein L6e//BESS motif GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003677 structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.10989 BP_3 18.01 0.47 2123 194755126 XP_001959843.1 262 5.7e-20 GF11831 [Drosophila ananassae]>gi|190621141|gb|EDV36665.1| GF11831 [Drosophila ananassae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 P26587 205 9.6e-15 Aquaporin TIP3-1 OS=Arabidopsis thaliana GN=TIP3-1 PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.10991 BP_3 35.34 7.76 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10994 BP_3 6.00 0.60 771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11 BP_3 6.00 0.70 707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.110 BP_3 12.00 4.58 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11000 BP_3 7.00 0.77 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11005 BP_3 54.00 2.25 1450 688549730 XP_009298900.1 474 1.0e-44 PREDICTED: gastrula zinc finger protein XlCGF57.1-like, partial [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96SE7 448 4.4e-43 Zinc finger protein 347 OS=Homo sapiens GN=ZNF347 PE=1 SV=2 PF13912//PF05864//PF16622//PF13465//PF00096//PF01155 C2H2-type zinc finger//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006351//GO:0006144//GO:0006206 cellular protein modification process//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0016151//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//nickel cation binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.1101 BP_3 3.00 0.41 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11017 BP_3 38.00 4.01 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11018 BP_3 2.00 10.73 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11020 BP_3 332.18 9.36 2003 675378821 KFM71723.1 515 2.5e-49 Zinc finger protein 271, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 483 5.3e-47 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF13465//PF00096//PF08675//PF01475//PF17123//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//RNA binding domain//Ferric uptake regulator family//RING-like zinc finger//C2H2-type zinc finger GO:0006402//GO:0006355//GO:0051252 mRNA catabolic process//regulation of transcription, DNA-templated//regulation of RNA metabolic process GO:0003723//GO:0005515//GO:0004535//GO:0008270//GO:0046872//GO:0003700 RNA binding//protein binding//poly(A)-specific ribonuclease activity//zinc ion binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005737 nucleus//transcription factor complex//cytoplasm -- -- Cluster-8309.11022 BP_3 193.45 3.25 3165 189234230 XP_973019.2 673 1.9e-67 PREDICTED: uncharacterized protein LOC661786 [Tribolium castaneum]>gi|270002409|gb|EEZ98856.1| hypothetical protein TcasGA2_TC004466 [Tribolium castaneum] -- -- -- -- -- K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83916 440 8.1e-42 Chromobox protein homolog 1 OS=Homo sapiens GN=CBX1 PE=1 SV=1 PF03119//PF02150//PF00130//PF01393//PF01096//PF01396//PF06160 NAD-dependent DNA ligase C4 zinc finger domain//RNA polymerases M/15 Kd subunit//Phorbol esters/diacylglycerol binding domain (C1 domain)//Chromo shadow domain//Transcription factor S-II (TFIIS)//Topoisomerase DNA binding C4 zinc finger//Septation ring formation regulator, EzrA GO:0006206//GO:0006144//GO:0000921//GO:0006351//GO:0035556//GO:0006265//GO:0006260//GO:0006281 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//septin ring assembly//transcription, DNA-templated//intracellular signal transduction//DNA topological change//DNA replication//DNA repair GO:0003676//GO:0003916//GO:0003677//GO:0003911//GO:0008270//GO:0003899 nucleic acid binding//DNA topoisomerase activity//DNA binding//DNA ligase (NAD+) activity//zinc ion binding//DNA-directed RNA polymerase activity GO:0005694//GO:0005634//GO:0005730//GO:0005940//GO:0016021 chromosome//nucleus//nucleolus//septin ring//integral component of membrane -- -- Cluster-8309.11023 BP_3 52.55 1.07 2656 189234230 XP_973019.2 535 1.6e-51 PREDICTED: uncharacterized protein LOC661786 [Tribolium castaneum]>gi|270002409|gb|EEZ98856.1| hypothetical protein TcasGA2_TC004466 [Tribolium castaneum] -- -- -- -- -- K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83917 331 2.9e-29 Chromobox protein homolog 1 OS=Mus musculus GN=Cbx1 PE=1 SV=1 PF01393//PF01096//PF00130//PF02150//PF06160//PF08131 Chromo shadow domain//Transcription factor S-II (TFIIS)//Phorbol esters/diacylglycerol binding domain (C1 domain)//RNA polymerases M/15 Kd subunit//Septation ring formation regulator, EzrA//Defensin-like peptide family GO:0035556//GO:0006206//GO:0000921//GO:0006144//GO:0006351 intracellular signal transduction//pyrimidine nucleobase metabolic process//septin ring assembly//purine nucleobase metabolic process//transcription, DNA-templated GO:0003676//GO:0008270//GO:0003677//GO:0003899 nucleic acid binding//zinc ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005576//GO:0005940//GO:0016021//GO:0005634 nucleolus//extracellular region//septin ring//integral component of membrane//nucleus -- -- Cluster-8309.11024 BP_3 3.00 1.60 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11025 BP_3 112.00 8.96 894 91083861 XP_974125.1 506 1.2e-48 PREDICTED: endocuticle structural glycoprotein SgAbd-2 [Tribolium castaneum]>gi|270006758|gb|EFA03206.1| hypothetical protein TcasGA2_TC013126 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 397 2.2e-37 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.11027 BP_3 5.00 0.46 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14984 CD24 protein GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.11028 BP_3 10.00 0.37 1578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00444 Ribosomal protein L36 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.11029 BP_3 4.00 1.81 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11033 BP_3 244.59 11.32 1333 270008876 EFA05324.1 1244 4.9e-134 hypothetical protein TcasGA2_TC015488 [Tribolium castaneum] -- -- -- -- -- K01197 hya hyaluronoglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01197 Q08169 896 4.5e-95 Hyaluronidase OS=Apis mellifera PE=1 SV=1 PF01630 Hyaluronidase GO:0005975 carbohydrate metabolic process GO:0004415 hyalurononglucosaminidase activity -- -- -- -- Cluster-8309.11037 BP_3 198.24 4.11 2615 478262843 ENN81328.1 1387 2.5e-150 hypothetical protein YQE_02264, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9ULM3 518 6.0e-51 YEATS domain-containing protein 2 OS=Homo sapiens GN=YEATS2 PE=1 SV=2 PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG3149 Transcription initiation factor IIF, auxiliary subunit Cluster-8309.1104 BP_3 5.00 0.34 1008 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11041 BP_3 59.00 2.19 1593 642936051 XP_008198282.1 1282 2.3e-138 PREDICTED: origin recognition complex subunit 5 [Tribolium castaneum]>gi|642936053|ref|XP_974215.2| PREDICTED: origin recognition complex subunit 5 [Tribolium castaneum]>gi|270014012|gb|EFA10460.1| hypothetical protein TcasGA2_TC012706 [Tribolium castaneum] -- -- -- -- -- K02607 ORC5 origin recognition complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02607 Q9WUV0 729 1.2e-75 Origin recognition complex subunit 5 OS=Mus musculus GN=Orc5 PE=2 SV=1 PF14630//PF00004 Origin recognition complex (ORC) subunit 5 C-terminus//ATPase family associated with various cellular activities (AAA) GO:0006260 DNA replication GO:0005524 ATP binding GO:0043229//GO:0005634//GO:0000808 intracellular organelle//nucleus//origin recognition complex KOG2543 Origin recognition complex, subunit 5 Cluster-8309.11047 BP_3 28.15 2.61 811 91091096 XP_968472.1 298 1.5e-24 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.11049 BP_3 26.00 0.31 4300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15332 Lck-interacting transmembrane adapter 1 GO:0050852//GO:0050853 T cell receptor signaling pathway//B cell receptor signaling pathway -- -- -- -- -- -- Cluster-8309.1105 BP_3 4.00 0.31 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11056 BP_3 2.00 0.33 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11058 BP_3 15.00 2.63 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11059 BP_3 32.71 1.39 1426 817011237 AKF11872.1 830 5.3e-86 putative juvenile hormone diol kinase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q10131 243 2.5e-19 Calexcitin-1 OS=Caenorhabditis elegans GN=cex-1 PE=3 SV=1 PF13202//PF09830//PF10591//PF13833//PF13405//PF00036//PF13499 EF hand//ATP adenylyltransferase//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0005509//GO:0003877 calcium ion binding//ATP adenylyltransferase activity GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.1106 BP_3 12.85 0.41 1807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11061 BP_3 110.00 2.44 2464 332373558 AEE61920.1 682 1.3e-68 unknown [Dendroctonus ponderosae]>gi|478261087|gb|ENN80642.1| hypothetical protein YQE_02929, partial [Dendroctonus ponderosae]>gi|546673882|gb|ERL85404.1| hypothetical protein D910_02824 [Dendroctonus ponderosae] -- -- -- -- -- K17790 TIM22 mitochondrial import inner membrane translocase subunit TIM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17790 Q8IN78 509 6.3e-50 Mitochondrial import inner membrane translocase subunit Tim22 OS=Drosophila melanogaster GN=Tim22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3225 Mitochondrial import inner membrane translocase, subunit TIM22 Cluster-8309.11062 BP_3 74.00 4.49 1086 91085453 XP_969413.1 599 2.5e-59 PREDICTED: mediator of RNA polymerase II transcription subunit 21 [Tribolium castaneum]>gi|270008396|gb|EFA04844.1| hypothetical protein TcasGA2_TC014894 [Tribolium castaneum] -- -- -- -- -- K15152 MED21, SRB7 mediator of RNA polymerase II transcription subunit 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15152 Q16RX1 477 1.4e-46 Mediator of RNA polymerase II transcription subunit 21 OS=Aedes aegypti GN=MED21 PE=3 SV=1 PF06152//PF04111//PF06100 Phage minor capsid protein 2//Autophagy protein Apg6//MCRA family GO:0006914//GO:0006631 autophagy//fatty acid metabolic process GO:0005198//GO:0050151//GO:0071949 structural molecule activity//oleate hydratase activity//FAD binding GO:0019028 viral capsid KOG1510 RNA polymerase II holoenzyme and mediator subcomplex, subunit SURB7/SRB7 Cluster-8309.11064 BP_3 281.71 4.88 3073 91081139 XP_975550.1 1584 4.2e-173 PREDICTED: uncharacterized protein LOC664451 [Tribolium castaneum]>gi|270005285|gb|EFA01733.1| hypothetical protein TcasGA2_TC007326 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 140 4.8e-07 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF13851//PF10186//PF07058//PF16331//PF04977//PF04111//PF02050//PF17060//PF17078//PF00769//PF00038//PF02601//PF10473//PF08988//PF03938 Growth-arrest specific micro-tubule binding//Vacuolar sorting 38 and autophagy-related subunit 14//Microtubule-associated protein 70//TolA binding protein trimerisation//Septum formation initiator//Autophagy protein Apg6//Flagellar FliJ protein//Monopolar spindle protein 2//SWI5-dependent HO expression protein 3//Ezrin/radixin/moesin family//Intermediate filament protein//Exonuclease VII, large subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Type III secretion system, cytoplasmic E component of needle//Outer membrane protein (OmpH-like) GO:0006935//GO:0051028//GO:0071973//GO:0030474//GO:0048870//GO:0048309//GO:0007049//GO:0010508//GO:0009405//GO:0006914//GO:0007010//GO:0070206//GO:0071988//GO:0006308 chemotaxis//mRNA transport//bacterial-type flagellum-dependent cell motility//spindle pole body duplication//cell motility//endoplasmic reticulum inheritance//cell cycle//positive regulation of autophagy//pathogenesis//autophagy//cytoskeleton organization//protein trimerization//protein localization to spindle pole body//DNA catabolic process GO:0051082//GO:0008134//GO:0045502//GO:0003774//GO:0008092//GO:0005198//GO:0042803//GO:0008017//GO:0008855 unfolded protein binding//transcription factor binding//dynein binding//motor activity//cytoskeletal protein binding//structural molecule activity//protein homodimerization activity//microtubule binding//exodeoxyribonuclease VII activity GO:0009318//GO:0009288//GO:0019898//GO:0005882//GO:0045298//GO:0030286//GO:0005667//GO:0005737//GO:0031514//GO:0016020 exodeoxyribonuclease VII complex//bacterial-type flagellum//extrinsic component of membrane//intermediate filament//tubulin complex//dynein complex//transcription factor complex//cytoplasm//motile cilium//membrane -- -- Cluster-8309.11067 BP_3 13.00 0.67 1231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11068 BP_3 12.00 0.53 1381 642937391 XP_008198818.1 447 1.3e-41 PREDICTED: carboxypeptidase N subunit 2-like [Tribolium castaneum]>gi|270001112|gb|EEZ97559.1| hypothetical protein TcasGA2_TC011413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5M3 245 1.4e-19 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.11073 BP_3 7.67 0.76 780 642936195 XP_008198341.1 491 5.9e-47 PREDICTED: sp-like zinc finger transcription factor isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11078 BP_3 115.91 2.66 2391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11080 BP_3 41.00 0.96 2358 558131945 XP_006116544.1 459 9.1e-43 PREDICTED: LOW QUALITY PROTEIN: cell division cycle-associated protein 7 [Pelodiscus sinensis] -- -- -- -- -- -- -- -- -- Q9BWT1 429 1.1e-40 Cell division cycle-associated protein 7 OS=Homo sapiens GN=CDCA7 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11082 BP_3 170.41 4.41 2154 546676105 ERL87172.1 1153 2.8e-123 hypothetical protein D910_04572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7K175 535 5.3e-53 Small RNA 2'-O-methyltransferase OS=Drosophila melanogaster GN=Hen1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1045 Uncharacterized conserved protein HEN1/CORYMBOSA2 Cluster-8309.11084 BP_3 5.62 0.44 908 662212463 XP_008479968.1 149 3.1e-07 PREDICTED: zinc finger protein 37-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1109 BP_3 22.00 2.62 696 642914225 XP_008201597.1 978 1.8e-103 PREDICTED: ras-related protein Rab-8A [Tribolium castaneum] 768439325 XM_011562986.1 156 5.78473e-74 PREDICTED: Plutella xylostella ras-related protein Rab-8A (LOC105391505), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 Q5F470 522 5.5e-52 Ras-related protein Rab-8A OS=Gallus gallus GN=RAB8A PE=2 SV=1 PF01637//PF04042//PF04670//PF00071//PF01926//PF00735//PF08477//PF00025//PF02421//PF00004 Archaeal ATPase//DNA polymerase alpha/epsilon subunit B//Gtr1/RagA G protein conserved region//Ras family//50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B//ATPase family associated with various cellular activities (AAA) GO:0015684//GO:0007264//GO:0006260 ferrous iron transport//small GTPase mediated signal transduction//DNA replication GO:0005525//GO:0003887//GO:0003677//GO:0005524//GO:0015093 GTP binding//DNA-directed DNA polymerase activity//DNA binding//ATP binding//ferrous iron transmembrane transporter activity GO:0042575//GO:0016021 DNA polymerase complex//integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.111 BP_3 3.00 0.79 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11100 BP_3 2.00 8.87 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11104 BP_3 18.00 0.43 2322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11107 BP_3 807.00 13.80 3110 642924943 XP_008194107.1 844 2.7e-87 PREDICTED: neuronal pentraxin receptor-like [Tribolium castaneum]>gi|642924945|ref|XP_008194108.1| PREDICTED: neuronal pentraxin receptor-like [Tribolium castaneum]>gi|270008029|gb|EFA04477.1| hypothetical protein TcasGA2_TC014781 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AVA0 156 6.8e-09 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus GN=Svep1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1111 BP_3 30.00 7.04 497 91091644 XP_970770.1 283 4.9e-23 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000890|gb|EEZ97337.1| hypothetical protein TcasGA2_TC011149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 200 8.5e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.11114 BP_3 43.97 1.31 1912 270015076 EFA11524.1 469 5.1e-44 hypothetical protein TcasGA2_TC014239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11116 BP_3 5.00 0.39 916 546687063 ERL95973.1 482 7.6e-46 hypothetical protein D910_00717 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8I7P9 214 3.7e-16 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683//PF02865 Integrase core domain//Integrase core domain//STAT protein, protein interaction domain GO:0006355//GO:0007165//GO:0015074 regulation of transcription, DNA-templated//signal transduction//DNA integration GO:0004871//GO:0003700 signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.11118 BP_3 85.34 1.30 3460 546671902 ERL84010.1 958 1.8e-100 hypothetical protein D910_01329 [Dendroctonus ponderosae] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 641 4.3e-65 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF00245//PF01355 Alkaline phosphatase//High potential iron-sulfur protein GO:0008152//GO:0006118//GO:0019646 metabolic process//obsolete electron transport//aerobic electron transport chain GO:0009055//GO:0016791 electron carrier activity//phosphatase activity -- -- -- -- Cluster-8309.11119 BP_3 64.74 0.61 5394 546671902 ERL84010.1 1755 1.1e-192 hypothetical protein D910_01329 [Dendroctonus ponderosae] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 1122 1.1e-120 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF01355//PF01663//PF01676//PF00884//PF00245//PF01035 High potential iron-sulfur protein//Type I phosphodiesterase / nucleotide pyrophosphatase//Metalloenzyme superfamily//Sulfatase//Alkaline phosphatase//6-O-methylguanine DNA methyltransferase, DNA binding domain GO:0008152//GO:0006281//GO:0019646//GO:0006118 metabolic process//DNA repair//aerobic electron transport chain//obsolete electron transport GO:0003824//GO:0016791//GO:0009055//GO:0008484//GO:0046872 catalytic activity//phosphatase activity//electron carrier activity//sulfuric ester hydrolase activity//metal ion binding -- -- -- -- Cluster-8309.11120 BP_3 4.20 0.36 854 646720584 KDR22245.1 138 5.5e-06 GMP reductase 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11121 BP_3 5.82 0.46 908 646720584 KDR22245.1 138 5.9e-06 GMP reductase 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11128 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1113 BP_3 2.00 0.63 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11130 BP_3 112.00 2.68 2309 861625527 KMQ88569.1 514 3.8e-49 retrovirus-like pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 176 2.4e-11 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.11131 BP_3 81.74 1.62 2719 167234455 NP_001107843.1 1160 5.5e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.5e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11134 BP_3 1.00 0.41 407 589960858 XP_006993004.1 597 1.6e-59 PREDICTED: 60S ribosomal protein L27 [Peromyscus maniculatus bairdii] 694966814 XM_001159277.4 407 0 PREDICTED: Pan troglodytes ribosomal protein L27 (RPL27), mRNA K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 P61354 583 2.7e-59 60S ribosomal protein L27 OS=Rattus norvegicus GN=Rpl27 PE=2 SV=2 PF01777 Ribosomal L27e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3418 60S ribosomal protein L27 Cluster-8309.11137 BP_3 170.33 5.60 1757 91079032 XP_974956.1 907 7.7e-95 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270003667|gb|EFA00115.1| hypothetical protein TcasGA2_TC002931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.11139 BP_3 22.16 1.41 1049 642929434 XP_008195838.1 799 1.5e-82 PREDICTED: transcription initiation factor TFIID subunit 8-like [Tribolium castaneum]>gi|270010530|gb|EFA06978.1| hypothetical protein TcasGA2_TC009938 [Tribolium castaneum] -- -- -- -- -- K14649 TAF8 transcription initiation factor TFIID subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14649 Q9VWY6 442 1.6e-42 Transcription initiation factor TFIID subunit 8 OS=Drosophila melanogaster GN=Taf8 PE=1 SV=1 PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.11140 BP_3 477.00 3.67 6554 189236209 XP_971084.2 7938 0.0e+00 PREDICTED: cadherin-related tumor suppressor [Tribolium castaneum] -- -- -- -- -- K16669 FAT4 protocadherin Fat 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16669 P33450 6028 0.0e+00 Cadherin-related tumor suppressor OS=Drosophila melanogaster GN=ft PE=1 SV=3 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.11143 BP_3 13.00 0.51 1521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11144 BP_3 25.52 0.70 2052 478259032 ENN78978.1 980 3.1e-103 hypothetical protein YQE_04562, partial [Dendroctonus ponderosae]>gi|546684154|gb|ERL93859.1| hypothetical protein D910_11145 [Dendroctonus ponderosae] 571543566 XM_006559674.1 150 3.81396e-70 PREDICTED: Apis mellifera putative homeodomain transcription factor-like (LOC551885), mRNA -- -- -- -- Q9V9A8 811 5.0e-85 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.11150 BP_3 61.70 0.51 6130 91079364 XP_970368.1 1910 1.3e-210 PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917122|ref|XP_008191123.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917124|ref|XP_008191125.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|270004364|gb|EFA00812.1| hypothetical protein TcasGA2_TC003699 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P5W1 634 5.0e-64 Vacuolar protein sorting-associated protein 8 homolog OS=Mus musculus GN=Vps8 PE=2 SV=1 PF12861//PF13374//PF00637//PF13639//PF17122//PF08053//PF00628//PF14634//PF02148//PF17123//PF12678 Anaphase-promoting complex subunit 11 RING-H2 finger//Tetratricopeptide repeat//Region in Clathrin and VPS//Ring finger domain//Zinc-finger//Tryptophanase operon leader peptide//PHD-finger//zinc-RING finger domain//Zn-finger in ubiquitin-hydrolases and other protein//RING-like zinc finger//RING-H2 zinc finger GO:0006886//GO:0016567//GO:0016192//GO:0031554//GO:0031556 intracellular protein transport//protein ubiquitination//vesicle-mediated transport//regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome GO:0005515//GO:0004842//GO:0008270//GO:0046872 protein binding//ubiquitin-protein transferase activity//zinc ion binding//metal ion binding GO:0005680//GO:0005622 anaphase-promoting complex//intracellular KOG2079 Vacuolar assembly/sorting protein VPS8 Cluster-8309.11151 BP_3 80.61 1.11 3779 642936806 XP_008199624.1 2898 0.0e+00 PREDICTED: protein sickie isoform X2 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 4.2e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF01443//PF03796//PF06156//PF01695//PF07728//PF08172//PF00004//PF13851//PF02562//PF09726//PF03836//PF08702//PF00910//PF00769 Viral (Superfamily 1) RNA helicase//DnaB-like helicase C terminal domain//Protein of unknown function (DUF972)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//CASP C terminal//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//PhoH-like protein//Transmembrane protein//RasGAP C-terminus//Fibrinogen alpha/beta chain family//RNA helicase//Ezrin/radixin/moesin family GO:0051258//GO:0007165//GO:0006260//GO:0048870//GO:0006891//GO:0007264//GO:0030168 protein polymerization//signal transduction//DNA replication//cell motility//intra-Golgi vesicle-mediated transport//small GTPase mediated signal transduction//platelet activation GO:0005096//GO:0005524//GO:0005102//GO:0016887//GO:0003678//GO:0008092//GO:0003723//GO:0003724//GO:0030674 GTPase activator activity//ATP binding//receptor binding//ATPase activity//DNA helicase activity//cytoskeletal protein binding//RNA binding//RNA helicase activity//protein binding, bridging GO:0031514//GO:0016021//GO:0019898//GO:0005577//GO:0005737//GO:0005657//GO:0030173 motile cilium//integral component of membrane//extrinsic component of membrane//fibrinogen complex//cytoplasm//replication fork//integral component of Golgi membrane -- -- Cluster-8309.11155 BP_3 15.52 0.35 2420 332375488 AEE62885.1 1123 9.5e-120 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02089 CDK4 cyclin-dependent kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02089 Q91727 797 2.5e-83 Cyclin-dependent kinase 4 OS=Xenopus laevis GN=cdk4 PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.11158 BP_3 17.39 5.63 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11159 BP_3 371.00 8.70 2348 478253706 ENN74005.1 643 4.2e-64 hypothetical protein YQE_09395, partial [Dendroctonus ponderosae]>gi|546678195|gb|ERL88885.1| hypothetical protein D910_06267 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P00771 284 7.3e-24 Brachyurin OS=Uca pugilator PE=1 SV=2 PF04111//PF05837//PF02477//PF00089//PF10186 Autophagy protein Apg6//Centromere protein H (CENP-H)//Nucleocapsid N protein//Trypsin//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006508//GO:0051382//GO:0006914//GO:0010508 proteolysis//kinetochore assembly//autophagy//positive regulation of autophagy GO:0004252 serine-type endopeptidase activity GO:0000776//GO:0019013 kinetochore//viral nucleocapsid -- -- Cluster-8309.11165 BP_3 174.63 9.14 1213 642926052 XP_970129.2 638 8.2e-64 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 192 1.8e-13 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11170 BP_3 6.15 0.36 1114 642914939 XP_008190450.1 330 3.9e-28 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q1LXK5 228 1.1e-17 Putative helicase mov-10-B.2 OS=Danio rerio GN=mov10b.2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.11173 BP_3 3.00 0.35 703 478257238 ENN77401.1 412 7.6e-38 hypothetical protein YQE_06226, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11175 BP_3 388.00 5.58 3645 270013613 EFA10061.1 1191 1.9e-127 hypothetical protein TcasGA2_TC012235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q291H8 545 6.2e-54 Facilitated trehalose transporter Tret1 OS=Drosophila pseudoobscura pseudoobscura GN=Tret1 PE=3 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.11177 BP_3 1.00 0.35 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11178 BP_3 5.02 0.63 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11180 BP_3 7.00 0.45 1042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11185 BP_3 117.00 5.08 1401 546673408 ERL85020.1 274 1.5e-21 hypothetical protein D910_02443 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.11191 BP_3 99.00 3.71 1577 91080979 XP_974925.1 843 1.8e-87 PREDICTED: uncharacterized protein LOC663797 [Tribolium castaneum]>gi|270005969|gb|EFA02417.1| hypothetical protein TcasGA2_TC008102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11194 BP_3 38.41 0.69 2973 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11195 BP_3 5.00 0.73 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1120 BP_3 17.21 0.58 1726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11200 BP_3 53.46 1.41 2121 676433751 XP_009047002.1 461 4.8e-43 hypothetical protein LOTGIDRAFT_54048, partial [Lottia gigantea]>gi|556113642|gb|ESP02294.1| hypothetical protein LOTGIDRAFT_54048, partial [Lottia gigantea] -- -- -- -- -- K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O14672 369 9.2e-34 Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens GN=ADAM10 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.11202 BP_3 44.04 5.54 675 642927339 XP_008195226.1 215 5.1e-15 PREDICTED: uncharacterized protein LOC103313529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11207 BP_3 12.29 0.66 1191 270010184 EFA06632.1 1039 2.6e-110 hypothetical protein TcasGA2_TC009552 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08300 Hepatitis C virus non-structural 5a zinc finger domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.11208 BP_3 2.00 1.54 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11211 BP_3 34.85 1.51 1401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11214 BP_3 236.15 4.06 3092 478260277 ENN80029.1 3743 0.0e+00 hypothetical protein YQE_03506, partial [Dendroctonus ponderosae] 749790992 XM_011150385.1 111 2.76483e-48 PREDICTED: Harpegnathos saltator DNA replication licensing factor MCM4 (LOC105188757), transcript variant X3, mRNA K02212 MCM4, CDC54 DNA replication licensing factor MCM4 http://www.genome.jp/dbget-bin/www_bget?ko:K02212 Q26454 3318 0.0e+00 DNA replication licensing factor MCM4 OS=Drosophila melanogaster GN=dpa PE=1 SV=2 PF05460//PF00493//PF07726//PF00004//PF13545//PF05669//PF00158//PF07728 Origin recognition complex subunit 6 (ORC6)//MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//ATPase family associated with various cellular activities (AAA)//Crp-like helix-turn-helix domain//SOH1//Sigma-54 interaction domain//AAA domain (dynein-related subfamily) GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008134//GO:0001104//GO:0003677//GO:0005524//GO:0016887 transcription factor binding//RNA polymerase II transcription cofactor activity//DNA binding//ATP binding//ATPase activity GO:0005664//GO:0005667//GO:0016592 nuclear origin of replication recognition complex//transcription factor complex//mediator complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.11217 BP_3 11.88 0.45 1570 270008571 EFA05019.1 931 1.1e-97 hypothetical protein TcasGA2_TC015105 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11221 BP_3 2.00 0.45 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11225 BP_3 16.00 0.84 1209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11226 BP_3 63.00 8.05 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11228 BP_3 4.00 1.95 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11229 BP_3 37.68 0.46 4200 270011230 EFA07678.1 1358 9.3e-147 hypothetical protein TcasGA2_TC030711 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 726 7.3e-75 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.11230 BP_3 401.68 6.05 3490 189237657 XP_001812177.1 794 1.9e-81 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 352 1.4e-31 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01428 AN1-like Zinc finger -- -- GO:0008270 zinc ion binding -- -- KOG3183 Predicted Zn-finger protein Cluster-8309.11234 BP_3 45.67 0.96 2582 546675694 ERL86836.1 661 3.8e-66 hypothetical protein D910_04239 [Dendroctonus ponderosae] -- -- -- -- -- K15865 CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15865 Q291H5 555 3.0e-55 Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Drosophila pseudoobscura pseudoobscura GN=GA19679 PE=3 SV=1 PF00919//PF05818 Uncharacterized protein family UPF0004//Enterobacterial TraT complement resistance protein GO:0009451//GO:0046999 RNA modification//regulation of conjugation GO:0003824//GO:0051539 catalytic activity//4 iron, 4 sulfur cluster binding GO:0019867 outer membrane KOG4355 Predicted Fe-S oxidoreductase Cluster-8309.11236 BP_3 9.20 0.41 1369 332372666 AEE61475.1 568 1.2e-55 unknown [Dendroctonus ponderosae]>gi|546681209|gb|ERL91344.1| hypothetical protein D910_08676 [Dendroctonus ponderosae] -- -- -- -- -- K17259 CIB1 calcium and integrin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17259 Q17QE5 251 2.9e-20 Calcium and integrin-binding protein 1 OS=Bos taurus GN=CIB1 PE=2 SV=1 PF01640//PF13499//PF00036//PF13833//PF13405 Peptidase C10 family//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain GO:0006508 proteolysis GO:0005509//GO:0008234 calcium ion binding//cysteine-type peptidase activity -- -- KOG0038 Ca2+-binding kinase interacting protein (KIP) (EF-Hand protein superfamily) Cluster-8309.11237 BP_3 26.80 1.11 1452 332372666 AEE61475.1 568 1.3e-55 unknown [Dendroctonus ponderosae]>gi|546681209|gb|ERL91344.1| hypothetical protein D910_08676 [Dendroctonus ponderosae] -- -- -- -- -- K17259 CIB1 calcium and integrin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17259 Q17QE5 251 3.0e-20 Calcium and integrin-binding protein 1 OS=Bos taurus GN=CIB1 PE=2 SV=1 PF01640//PF13499//PF13833//PF00036//PF13405 Peptidase C10 family//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain GO:0006508 proteolysis GO:0005509//GO:0008234 calcium ion binding//cysteine-type peptidase activity -- -- KOG0038 Ca2+-binding kinase interacting protein (KIP) (EF-Hand protein superfamily) Cluster-8309.11238 BP_3 6.00 0.43 964 91076104 XP_968648.1 215 7.3e-15 PREDICTED: 1,4-alpha-glucan-branching enzyme [Tribolium castaneum]>gi|270014582|gb|EFA11030.1| hypothetical protein TcasGA2_TC004619 [Tribolium castaneum] -- -- -- -- -- K00700 glgB 1,4-alpha-glucan branching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K00700 Q9D6Y9 175 1.3e-11 1,4-alpha-glucan-branching enzyme OS=Mus musculus GN=Gbe1 PE=2 SV=1 -- -- GO:0005975//GO:0005982//GO:0005978//GO:0005985 carbohydrate metabolic process//starch metabolic process//glycogen biosynthetic process//sucrose metabolic process GO:0003844//GO:0004553//GO:0043169 1,4-alpha-glucan branching enzyme activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- KOG0470 1,4-alpha-glucan branching enzyme/starch branching enzyme II Cluster-8309.11239 BP_3 99.57 1.17 4411 270009849 EFA06297.1 1167 1.4e-124 hypothetical protein TcasGA2_TC009164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AKG8 300 1.9e-25 Focadhesin OS=Mus musculus GN=Focad PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1124 BP_3 5.00 0.69 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00416 Ribosomal protein S13/S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.11241 BP_3 10.30 0.77 940 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11242 BP_3 69.71 0.76 4700 270008031 EFA04479.1 590 1.2e-57 hypothetical protein TcasGA2_TC014783 [Tribolium castaneum] 462438590 APGK01012118.1 63 2.03388e-21 Dendroctonus ponderosae Seq01012126, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11243 BP_3 19.20 0.51 2093 270014603 EFA11051.1 779 6.4e-80 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] -- -- -- -- -- K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 463 1.1e-44 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.11245 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11247 BP_3 64.65 0.60 5522 642933323 XP_008197368.1 1156 3.2e-123 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 668 5.1e-68 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.11249 BP_3 9.55 1.92 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1125 BP_3 122.00 6.46 1202 332376507 AEE63393.1 482 1.0e-45 unknown [Dendroctonus ponderosae]>gi|478259336|gb|ENN79238.1| hypothetical protein YQE_04422, partial [Dendroctonus ponderosae]>gi|546675074|gb|ERL86329.1| hypothetical protein D910_03737 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11251 BP_3 4.00 0.84 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11252 BP_3 6.00 0.50 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11254 BP_3 122.00 2.58 2571 642921297 XP_008192807.1 2482 2.6e-277 PREDICTED: spermatogenesis-associated protein 5 [Tribolium castaneum] 294939026 XM_002782252.1 35 4.06413e-06 Perkinsus marinus ATCC 50983 cell division cycle protein 48, putative, mRNA K14575 AFG2, DRG1, SPATA5 AAA family ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14575 Q8NB90 1328 7.0e-145 Spermatogenesis-associated protein 5 OS=Homo sapiens GN=SPATA5 PE=1 SV=3 PF07726//PF03193//PF00005//PF00270//PF10662//PF00910//PF14532//PF06068//PF05496//PF00437//PF07724//PF02367//PF06414//PF02562//PF07728//PF01745//PF01695//PF00158//PF00004 ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//DEAD/DEAH box helicase//Ethanolamine utilisation - propanediol utilisation//RNA helicase//Sigma-54 interaction domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein//AAA domain (dynein-related subfamily)//Isopentenyl transferase//IstB-like ATP binding protein//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA) GO:0006355//GO:0006694//GO:0009058//GO:0016114//GO:0006810//GO:0006281//GO:0002949//GO:0006310//GO:0006576 regulation of transcription, DNA-templated//steroid biosynthetic process//biosynthetic process//terpenoid biosynthetic process//transport//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//cellular biogenic amine metabolic process GO:0016301//GO:0004161//GO:0016887//GO:0005524//GO:0003924//GO:0008134//GO:0005525//GO:0003676//GO:0009378//GO:0003724//GO:0003678//GO:0003723 kinase activity//dimethylallyltranstransferase activity//ATPase activity//ATP binding//GTPase activity//transcription factor binding//GTP binding//nucleic acid binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0730 AAA+-type ATPase Cluster-8309.11258 BP_3 51.11 1.06 2615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1126 BP_3 5.00 0.39 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11260 BP_3 29.00 1.17 1486 642929412 XP_008195828.1 578 9.2e-57 PREDICTED: uncharacterized protein LOC663405 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165 signal transduction GO:0004871 signal transducer activity GO:0016020 membrane -- -- Cluster-8309.11261 BP_3 49.99 0.97 2785 167234455 NP_001107843.1 1160 5.6e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.6e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11262 BP_3 140.00 5.49 1521 546678561 ERL89150.1 531 2.6e-51 hypothetical protein D910_06526 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P52746 214 6.2e-16 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF10018//PF00096//PF04988//PF02150 Vitamin-D-receptor interacting Mediator subunit 4//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//RNA polymerases M/15 Kd subunit GO:0006357//GO:0006206//GO:0006144//GO:0006351 regulation of transcription from RNA polymerase II promoter//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003899//GO:0001104//GO:0003677 metal ion binding//DNA-directed RNA polymerase activity//RNA polymerase II transcription cofactor activity//DNA binding GO:0005730//GO:0005634//GO:0016592 nucleolus//nucleus//mediator complex KOG1721 FOG: Zn-finger Cluster-8309.11263 BP_3 308.00 16.83 1174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11264 BP_3 4.00 0.56 633 -- -- -- -- -- 768311759 CP010987.1 593 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11265 BP_3 4.00 0.84 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11266 BP_3 3.00 0.68 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11267 BP_3 7.43 0.80 739 826407466 XP_012543053.1 167 2.1e-09 PREDICTED: zinc finger protein 184-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- P42283 137 2.6e-07 Longitudinals lacking protein, isoform G OS=Drosophila melanogaster GN=lola PE=1 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.11269 BP_3 1743.00 25.26 3618 91079482 XP_968199.1 3043 0.0e+00 PREDICTED: uncharacterized protein LOC656585 [Tribolium castaneum]>gi|270004412|gb|EFA00860.1| hypothetical protein TcasGA2_TC003763 [Tribolium castaneum] 749789638 XM_011149827.1 310 7.71169e-159 PREDICTED: Harpegnathos saltator uncharacterized LOC105188407 (LOC105188407), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11272 BP_3 5.00 0.92 554 119623651 EAX03246.1 184 1.7e-11 major histocompatibility complex, class I, A, isoform CRA_g [Homo sapiens] 768052561 XM_011548124.1 550 0 PREDICTED: Homo sapiens major histocompatibility complex, class I, A (HLA-A), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF06623 MHC_I C-terminus GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- -- -- -- -- Cluster-8309.11274 BP_3 2.00 0.79 413 820987688 XP_012362358.1 715 3.3e-73 PREDICTED: translationally-controlled tumor protein isoform X3 [Nomascus leucogenys] 694911845 XM_001139202.4 404 0 PREDICTED: Pan troglodytes translationally-controlled tumor protein (LOC735922), mRNA -- -- -- -- P13693 715 1.4e-74 Translationally-controlled tumor protein OS=Homo sapiens GN=TPT1 PE=1 SV=1 PF03945 delta endotoxin, N-terminal domain GO:0009405 pathogenesis -- -- -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.11281 BP_3 5.00 0.36 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11287 BP_3 391.00 10.79 2039 646708587 KDR14836.1 553 1.0e-53 hypothetical protein L798_11281 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q09415 135 1.2e-06 SET domain-containing protein 14 OS=Caenorhabditis elegans GN=set-14 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.11288 BP_3 54.74 2.51 1344 478254316 ENN74570.1 404 1.2e-36 hypothetical protein YQE_08892, partial [Dendroctonus ponderosae]>gi|546674045|gb|ERL85533.1| hypothetical protein D910_02952 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1129 BP_3 7.00 1.02 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11290 BP_3 4.00 0.69 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11293 BP_3 68.00 2.22 1771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1130 BP_3 8.00 0.80 776 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11300 BP_3 6.00 1.00 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11306 BP_3 6.30 0.32 1250 270007789 EFA04237.1 513 2.7e-49 hypothetical protein TcasGA2_TC014490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4G0P3 352 5.1e-32 Hydrocephalus-inducing protein homolog OS=Homo sapiens GN=HYDIN PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11311 BP_3 1891.00 84.77 1367 270012491 EFA08939.1 153 1.6e-07 hypothetical protein TcasGA2_TC006646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11313 BP_3 18.80 0.48 2186 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11314 BP_3 20.00 1.04 1223 546678917 ERL89455.1 159 2.9e-08 hypothetical protein D910_06822 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11315 BP_3 5.29 0.49 813 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11318 BP_3 2501.07 167.60 1011 642939603 XP_008194617.1 625 2.2e-62 PREDICTED: uncharacterized protein LOC103313343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13508 Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.11324 BP_3 10.60 0.45 1433 91094905 XP_973449.1 1182 8.1e-127 PREDICTED: F-box/SPRY domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270006590|gb|EFA03038.1| hypothetical protein TcasGA2_TC010464 [Tribolium castaneum] 242007554 XM_002424560.1 186 2.56973e-90 Pediculus humanus corporis F-box/SPRY-domain protein, putative, mRNA K10319 FBXO45 F-box protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K10319 B4HQ29 1037 2.2e-111 F-box/SPRY domain-containing protein 1 OS=Drosophila sechellia GN=Fsn PE=3 SV=1 PF12937//PF00622//PF00646 F-box-like//SPRY domain//F-box domain -- -- GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.11326 BP_3 14.19 0.59 1457 642926982 XP_008195090.1 172 1.1e-09 PREDICTED: glutathione synthetase-like isoform X1 [Tribolium castaneum] 642913207 XM_008203216.1 66 1.33325e-23 PREDICTED: Tribolium castaneum zinc finger MIZ domain-containing protein 1 (LOC664124), transcript variant X2, mRNA K01920 gshB, GSS glutathione synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01920 -- -- -- -- PF03917 Eukaryotic glutathione synthase, ATP binding domain GO:0006750 glutathione biosynthetic process GO:0004363//GO:0005524 glutathione synthase activity//ATP binding -- -- -- -- Cluster-8309.11327 BP_3 5.00 1.25 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11328 BP_3 2.00 0.92 395 861587829 KMQ82562.1 250 2.6e-19 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11330 BP_3 2.64 4.27 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11334 BP_3 2.00 0.75 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11337 BP_3 48.00 3.66 923 478252342 ENN72768.1 269 3.8e-21 hypothetical protein YQE_10573, partial [Dendroctonus ponderosae]>gi|546680676|gb|ERL90902.1| hypothetical protein D910_08247 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1134 BP_3 18.00 0.66 1602 646706020 KDR13445.1 1242 1.0e-133 Tyrosine-protein kinase RYK, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9V422 754 1.6e-78 Tyrosine-protein kinase Dnt OS=Drosophila melanogaster GN=dnt PE=2 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1024 Receptor-like protein tyrosine kinase RYK/derailed Cluster-8309.11340 BP_3 16.77 0.85 1248 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11343 BP_3 1.00 0.51 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395//PF06151 7tm Chemosensory receptor//Trehalose receptor GO:0007607//GO:0050909//GO:0050912//GO:0007187 obsolete taste perception//sensory perception of taste//detection of chemical stimulus involved in sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.11349 BP_3 10.00 0.68 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1135 BP_3 19.00 1.29 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11355 BP_3 3.00 0.34 718 724938358 XP_010385257.1 1116 1.8e-119 PREDICTED: 40S ribosomal protein S5 [Rhinopithecus roxellana] 675738836 XM_003816643.2 640 0 PREDICTED: Pan paniscus ribosomal protein S5 (RPS5), mRNA >gnl|BL_ORD_ID|21071585 PREDICTED: Pan troglodytes ribosomal protein S5 (RPS5), mRNA K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 P46782 1042 2.9e-112 40S ribosomal protein S5 OS=Homo sapiens GN=RPS5 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-8309.11368 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1137 BP_3 8.00 4.59 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11375 BP_3 5.00 0.52 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11377 BP_3 35.25 1.22 1679 478250371 ENN70866.1 996 3.5e-105 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672861|gb|ERL84584.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 625 1.5e-63 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF00975//PF07859//PF02230//PF00326//PF01764 Thioesterase domain//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3) GO:0006629//GO:0009058//GO:0006508//GO:0008152 lipid metabolic process//biosynthetic process//proteolysis//metabolic process GO:0008236//GO:0016787//GO:0016788 serine-type peptidase activity//hydrolase activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.11378 BP_3 11.00 1.16 748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03131 bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.1138 BP_3 7.00 0.65 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11380 BP_3 1450.87 13.52 5464 642927353 XP_008195233.1 3614 0.0e+00 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 7-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TE60 682 1.2e-69 A disintegrin and metalloproteinase with thrombospondin motifs 18 OS=Homo sapiens GN=ADAMTS18 PE=1 SV=3 PF01421//PF15339//PF01562//PF00413 Reprolysin (M12B) family zinc metalloprotease//Acrosome formation-associated factor//Reprolysin family propeptide//Matrixin GO:0006897//GO:0007342//GO:0060478//GO:0006508 endocytosis//fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis//proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012//GO:0005886 extracellular matrix//plasma membrane KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.11384 BP_3 10.00 0.42 1437 270016028 EFA12476.1 257 1.5e-19 hypothetical protein TcasGA2_TC001500 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11387 BP_3 2.03 0.32 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11393 BP_3 168.36 2.22 3951 189234046 XP_968851.2 1200 1.8e-128 PREDICTED: uncharacterized protein LOC657290 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06626 CCNE cyclin E http://www.genome.jp/dbget-bin/www_bget?ko:K06626 P54733 648 7.7e-66 G1/S-specific cyclin-E OS=Drosophila melanogaster GN=CycE PE=1 SV=2 PF02984//PF00554 Cyclin, C-terminal domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0655 G1/S-specific cyclin E Cluster-8309.11394 BP_3 71.13 0.82 4455 270014475 EFA10923.1 1200 2.1e-128 hypothetical protein TcasGA2_TC001749 [Tribolium castaneum] -- -- -- -- -- K06626 CCNE cyclin E http://www.genome.jp/dbget-bin/www_bget?ko:K06626 P54733 648 8.6e-66 G1/S-specific cyclin-E OS=Drosophila melanogaster GN=CycE PE=1 SV=2 PF02984//PF00554 Cyclin, C-terminal domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0655 G1/S-specific cyclin E Cluster-8309.11395 BP_3 15.83 0.40 2217 546681961 ERL91957.1 493 9.8e-47 hypothetical protein D910_09280 [Dendroctonus ponderosae] -- -- -- -- -- K11667 INO80C, IES6 INO80 complex subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K11667 Q6PI98 282 1.2e-23 INO80 complex subunit C OS=Homo sapiens GN=INO80C PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4137 Uncharacterized conserved protein Cluster-8309.11396 BP_3 17.33 0.67 1537 170321839 BAG14264.1 338 6.4e-29 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q90WD8 219 1.7e-16 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.11399 BP_3 57.63 0.81 3729 270017202 EFA13648.1 1715 3.3e-188 hypothetical protein TcasGA2_TC015886 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 184 4.6e-12 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00589//PF00075//PF05869//PF13495 Phage integrase family//RNase H//DNA N-6-adenine-methyltransferase (Dam)//Phage integrase, N-terminal SAM-like domain GO:0006306//GO:0051252//GO:0015074//GO:0006310//GO:0032775 DNA methylation//regulation of RNA metabolic process//DNA integration//DNA recombination//DNA methylation on adenine GO:0009007//GO:0004523//GO:0003676//GO:0003677 site-specific DNA-methyltransferase (adenine-specific) activity//RNA-DNA hybrid ribonuclease activity//nucleic acid binding//DNA binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.11400 BP_3 1.00 0.76 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04049//PF03526 Anaphase promoting complex subunit 8 / Cdc23//Colicin E1 (microcin) immunity protein GO:0030071//GO:0006955//GO:0030153 regulation of mitotic metaphase/anaphase transition//immune response//bacteriocin immunity GO:0015643 toxic substance binding GO:0019814//GO:0005680 immunoglobulin complex//anaphase-promoting complex -- -- Cluster-8309.11404 BP_3 3.00 1.88 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11405 BP_3 1.00 16.18 231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11406 BP_3 15.00 21.00 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11415 BP_3 16.03 1.01 1053 642931766 XP_008196719.1 148 4.7e-07 PREDICTED: cytohesin-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11417 BP_3 152.00 1.52 5100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11418 BP_3 3.00 0.69 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11419 BP_3 3.00 0.43 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11422 BP_3 17562.98 613.75 1671 91077622 XP_973873.1 451 5.5e-42 PREDICTED: histidine-rich glycoprotein [Tribolium castaneum]>gi|270001552|gb|EEZ97999.1| hypothetical protein TcasGA2_TC000397 [Tribolium castaneum] 749746005 XM_011136763.1 100 1.92886e-42 PREDICTED: Harpegnathos saltator histidine-rich glycoprotein (LOC105180595), partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11429 BP_3 36.79 0.56 3475 189234553 XP_973928.2 1623 1.4e-177 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] 571543566 XM_006559674.1 150 6.50079e-70 PREDICTED: Apis mellifera putative homeodomain transcription factor-like (LOC551885), mRNA -- -- -- -- Q9V9A8 918 3.3e-97 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.11430 BP_3 70.00 1.88 2083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11431 BP_3 466.61 6.62 3691 642917889 XP_008191371.1 1666 1.6e-182 PREDICTED: regulator of chromosome condensation [Tribolium castaneum]>gi|642917891|ref|XP_008191372.1| PREDICTED: regulator of chromosome condensation [Tribolium castaneum] -- -- -- -- -- K11493 RCC1 regulator of chromosome condensation http://www.genome.jp/dbget-bin/www_bget?ko:K11493 P25183 874 4.4e-92 Regulator of chromosome condensation OS=Xenopus laevis GN=rcc1 PE=2 SV=1 PF01405//PF03989 Photosystem II reaction centre T protein//DNA gyrase C-terminal domain, beta-propeller GO:0015979//GO:0006265 photosynthesis//DNA topological change GO:0005524//GO:0003677//GO:0003916 ATP binding//DNA binding//DNA topoisomerase activity GO:0016020//GO:0005694//GO:0009539//GO:0009523 membrane//chromosome//photosystem II reaction center//photosystem II KOG1426 FOG: RCC1 domain Cluster-8309.11438 BP_3 166.52 14.45 847 91078752 XP_968271.1 858 1.8e-89 PREDICTED: U1 small nuclear ribonucleoprotein A [Tribolium castaneum]>gi|270003743|gb|EFA00191.1| hypothetical protein TcasGA2_TC003016 [Tribolium castaneum] 259016064 GQ265634.1 104 5.73002e-45 Muscidifurax raptorellus voucher NCSU:BMW DTOL-803 sans fille (SNF) mRNA, partial cds K11094 SNRPB2 U2 small nuclear ribonucleoprotein B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11094 P43332 710 1.1e-73 U1 small nuclear ribonucleoprotein A OS=Drosophila melanogaster GN=snf PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0000398 mRNA splicing, via spliceosome GO:0000166//GO:0003676//GO:0017069 nucleotide binding//nucleic acid binding//snRNA binding -- -- KOG4206 Spliceosomal protein snRNP-U1A/U2B Cluster-8309.11443 BP_3 6.00 0.38 1059 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11444 BP_3 6.00 1.09 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11448 BP_3 32.06 0.56 3066 642915474 XP_008190634.1 2307 6.1e-257 PREDICTED: sorting nexin-14-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5W7 868 1.8e-91 Sorting nexin-14 OS=Homo sapiens GN=SNX14 PE=1 SV=3 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.1145 BP_3 3.00 0.47 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11451 BP_3 1.00 11.30 240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00837 Iodothyronine deiodinase GO:0055114 oxidation-reduction process GO:0004800 thyroxine 5'-deiodinase activity -- -- -- -- Cluster-8309.11453 BP_3 13820.89 2146.68 602 270006771 EFA03219.1 510 2.8e-49 hypothetical protein TcasGA2_TC013139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 289 4.9e-25 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.11457 BP_3 62.20 1.67 2088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11458 BP_3 12.31 0.84 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1146 BP_3 41.36 1.14 2044 642928681 XP_008199734.1 538 5.5e-52 PREDICTED: uncharacterized protein LOC662519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11462 BP_3 5.00 0.76 610 545808738 XP_003123559.3 984 3.1e-104 PREDICTED: 60S ribosomal protein L18a isoformX1 [Sus scrofa]>gi|675970145|pdb|4W20|S Chain S, Structure Of The Mammalian 60s Ribosomal Subunit (this Entry Contains The Large Ribosomal Proteins)>gi|675970196|pdb|4W22|S Chain S, Structure Of The 80s Mammalian Ribosome Bound To Eef2 (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970287|pdb|4W25|S Chain S, Structure Of The Idle Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970340|pdb|4W27|S Chain S, Structure Of The Translating Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins) 395132441 NM_000980.3 610 0 Homo sapiens ribosomal protein L18a (RPL18A), mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q3T003 950 1.1e-101 60S ribosomal protein L18a OS=Bos taurus GN=RPL18A PE=2 SV=1 PF01775 Ribosomal L18ae/LX protein domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.11463 BP_3 1.00 0.79 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11466 BP_3 4.00 0.56 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1147 BP_3 305.00 43.97 626 642922029 XP_008192991.1 387 5.4e-35 PREDICTED: uncharacterized protein LOC655936 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 270 8.2e-23 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF02282//PF00379 DNA polymerase processivity factor (UL42)//Insect cuticle protein GO:0006260 DNA replication GO:0042302//GO:0003677 structural constituent of cuticle//DNA binding -- -- -- -- Cluster-8309.11473 BP_3 27.49 1.67 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11479 BP_3 154.00 14.10 818 675370342 KFM63244.1 206 6.9e-14 THAP domain-containing protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF04037//PF15898//PF02183 THAP domain//Domain of unknown function (DUF382)//cGMP-dependent protein kinase interacting domain//Homeobox associated leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0019901//GO:0003676 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein kinase binding//nucleic acid binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.1148 BP_3 7.00 0.61 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11480 BP_3 2.00 0.32 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11484 BP_3 114.83 3.38 1928 91079546 XP_971272.1 196 2.3e-12 PREDICTED: uncharacterized protein LOC659913 [Tribolium castaneum]>gi|270003419|gb|EEZ99866.1| hypothetical protein TcasGA2_TC002648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10717//PF03505 Occlusion-derived virus envelope protein ODV-E18//Clostridium enterotoxin GO:0009405 pathogenesis -- -- GO:0005576//GO:0019031 extracellular region//viral envelope -- -- Cluster-8309.1149 BP_3 18.00 4.03 507 328899750 AEB54647.1 650 1.4e-65 ribosomal protein S18 [Procambarus clarkii]>gi|717007033|gb|AIW68599.1| ribosomal protein S18 [Cherax quadricarinatus] 328899749 HQ414569.1 264 3.80602e-134 Procambarus clarkii clone pc-273 ribosomal protein S18 mRNA, complete cds K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q8ISP0 603 1.6e-61 40S ribosomal protein S18 OS=Branchiostoma belcheri GN=RPS18 PE=2 SV=1 PF00416//PF06831 Ribosomal protein S13/S18//Formamidopyrimidine-DNA glycosylase H2TH domain GO:0042254//GO:0006289//GO:0006412//GO:0006281//GO:0006284 ribosome biogenesis//nucleotide-excision repair//translation//DNA repair//base-excision repair GO:0003684//GO:0008270//GO:0003735//GO:0003906//GO:0003723//GO:0016799 damaged DNA binding//zinc ion binding//structural constituent of ribosome//DNA-(apurinic or apyrimidinic site) lyase activity//RNA binding//hydrolase activity, hydrolyzing N-glycosyl compounds GO:0005840//GO:0005622 ribosome//intracellular KOG3311 Ribosomal protein S18 Cluster-8309.11493 BP_3 19.98 0.41 2651 478268676 ENN83233.1 280 5.9e-22 hypothetical protein YQE_00408, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10473 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 -- -- GO:0008134//GO:0045502//GO:0042803 transcription factor binding//dynein binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.11497 BP_3 67.76 1.08 3310 546679820 ERL90212.1 1294 1.9e-139 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP2 823 3.3e-86 Histone H4 transcription factor OS=Bos taurus GN=HINFP PE=2 SV=1 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.11500 BP_3 6.14 0.88 628 91078218 XP_969246.1 316 9.3e-27 PREDICTED: ubiquitin-like protein 5 [Tribolium castaneum]>gi|270002984|gb|EEZ99431.1| hypothetical protein TcasGA2_TC030562 [Tribolium castaneum] 815820526 XM_012376058.1 73 7.15579e-28 PREDICTED: Linepithema humile ubiquitin-like protein 5 (LOC105677441), mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q3T0Z3 280 5.7e-24 Ubiquitin-like protein 5 OS=Bos taurus GN=UBL5 PE=3 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-8309.11505 BP_3 22.00 0.58 2126 857969825 CEP03833.1 414 1.4e-37 hypothetical protein PBRA_003440 [Plasmodiophora brassicae] 302404025 XM_002999805.1 1555 0 Verticillium albo-atrum VaMs.102 peptide transporter PTR2-A, mRNA -- -- -- -- Q9P380 882 3.0e-93 Probable peptide transporter ptr2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ptr2 PE=1 SV=1 PF07690//PF00854 Major Facilitator Superfamily//POT family GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1237 H+/oligopeptide symporter Cluster-8309.11511 BP_3 37.19 0.91 2261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11513 BP_3 103.15 1.37 3933 270010437 EFA06885.1 2442 1.7e-272 hypothetical protein TcasGA2_TC009830 [Tribolium castaneum] 827546919 XM_004926175.2 138 3.45166e-63 PREDICTED: Bombyx mori protein prickle-like (LOC101737057), mRNA K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 A1Z6W3 1451 5.9e-159 Protein prickle OS=Drosophila melanogaster GN=pk PE=1 SV=1 PF01777//PF00412//PF06297//PF02529 Ribosomal L27e protein family//LIM domain//PET Domain//Cytochrome B6-F complex subunit 5 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0005840//GO:0009512//GO:0005622 ribosome//cytochrome b6f complex//intracellular KOG1704 FOG: LIM domain Cluster-8309.11514 BP_3 575.00 10.18 3014 270002841 EEZ99288.1 2179 4.2e-242 van-gogh [Tribolium castaneum] -- -- -- -- -- K04510 VANGL vang-like http://www.genome.jp/dbget-bin/www_bget?ko:K04510 Q91ZD4 1040 2.0e-111 Vang-like protein 2 OS=Mus musculus GN=Vangl2 PE=1 SV=3 PF06638 Strabismus protein GO:0007275 multicellular organismal development -- -- GO:0016021 integral component of membrane KOG3814 Signaling protein van gogh/strabismus Cluster-8309.11516 BP_3 12.03 0.38 1826 642929144 XP_008195712.1 1743 9.2e-192 PREDICTED: transcription factor AP-2 isoform X2 [Tribolium castaneum] 597797984 XM_007260483.1 100 2.11161e-42 PREDICTED: Astyanax mexicanus transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (tfap2b), mRNA K09179 TFAP2E transcription factor AP-2 epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09179 Q2T9K2 867 1.4e-91 Transcription factor AP-2-epsilon OS=Xenopus laevis GN=tfap2e PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3811 Transcription factor AP-2 Cluster-8309.11517 BP_3 14.81 0.37 2198 282158079 NP_001164083.1 1656 1.4e-181 transcription factor AP-2 [Tribolium castaneum] 597797984 XM_007260483.1 100 2.5502e-42 PREDICTED: Astyanax mexicanus transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (tfap2b), mRNA K09179 TFAP2E transcription factor AP-2 epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09179 Q2T9K2 867 1.7e-91 Transcription factor AP-2-epsilon OS=Xenopus laevis GN=tfap2e PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3811 Transcription factor AP-2 Cluster-8309.11518 BP_3 1.00 1.46 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11519 BP_3 4.00 1.35 434 642930000 XP_008196060.1 357 1.1e-31 PREDICTED: calphotin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 295 7.2e-26 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.11521 BP_3 377.00 16.13 1418 189234647 XP_001808029.1 740 1.4e-75 PREDICTED: DNA fragmentation factor subunit alpha [Tribolium castaneum]>gi|270001621|gb|EEZ98068.1| hypothetical protein TcasGA2_TC000475 [Tribolium castaneum] 642914004 XM_001807977.2 155 4.34518e-73 PREDICTED: Tribolium castaneum DNA fragmentation factor subunit alpha (LOC655663), mRNA -- -- -- -- O70303 192 2.1e-13 Cell death activator CIDE-B OS=Mus musculus GN=Cideb PE=1 SV=2 PF02017 CIDE-N domain GO:0006915 apoptotic process -- -- GO:0005622 intracellular -- -- Cluster-8309.11523 BP_3 16.63 1.42 858 189239684 XP_001814498.1 247 1.3e-18 PREDICTED: FMRFamide-related neuropeptides [Tribolium castaneum]>gi|270010961|gb|EFA07409.1| SIFa preprohormone [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q867W1 164 2.2e-10 FMRFamide-related neuropeptides OS=Procambarus clarkii PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11524 BP_3 5.52 0.49 840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11528 BP_3 5.39 0.38 968 270014029 EFA10477.1 227 3.0e-16 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 571562937 XM_006570457.1 56 3.17297e-18 PREDICTED: Apis mellifera uncharacterized LOC551624 (LOC551624), transcript variant X2, mRNA -- -- -- -- O94842 141 1.2e-07 TOX high mobility group box family member 4 OS=Homo sapiens GN=TOX4 PE=1 SV=1 PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.11530 BP_3 114.00 6.32 1161 91079764 XP_966717.1 1476 5.3e-161 PREDICTED: cyclin-dependent kinase 7 [Tribolium castaneum]>gi|270004513|gb|EFA00961.1| hypothetical protein TcasGA2_TC003871 [Tribolium castaneum] -- -- -- -- -- K02202 CDK7 cyclin-dependent kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K02202 P50613 1138 3.4e-123 Cyclin-dependent kinase 7 OS=Homo sapiens GN=CDK7 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7 Cluster-8309.1154 BP_3 1.00 1.10 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11540 BP_3 21.00 0.59 1995 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04810 Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.11541 BP_3 1.00 5.03 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11542 BP_3 175.79 2.97 3142 642930503 XP_008196431.1 966 2.0e-101 PREDICTED: uncharacterized protein LOC663881 [Tribolium castaneum]>gi|270010742|gb|EFA07190.1| hypothetical protein TcasGA2_TC010196 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- -- -- Cluster-8309.11543 BP_3 166.86 8.82 1204 642936729 XP_008198556.1 318 1.0e-26 PREDICTED: uncharacterized protein LOC103314384 [Tribolium castaneum]>gi|270000961|gb|EEZ97408.1| hypothetical protein TcasGA2_TC011237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11547 BP_3 8.00 0.33 1463 861610909 KMQ85195.1 230 2.0e-16 nuclease harbi1, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11553 BP_3 125.63 3.53 2006 91093748 XP_969297.1 997 3.2e-105 PREDICTED: cerebellar degeneration-related protein 2-like isoform X1 [Tribolium castaneum]>gi|270013015|gb|EFA09463.1| hypothetical protein TcasGA2_TC010679 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 334 1.0e-29 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF08172//PF00170//PF08941//PF05929//PF04111//PF05791//PF06009//PF04977//PF06156//PF17078//PF01025//PF07926//PF10473 CASP C terminal//bZIP transcription factor//USP8 interacting//Phage capsid scaffolding protein (GPO) serine peptidase//Autophagy protein Apg6//Bacillus haemolytic enterotoxin (HBL)//Laminin Domain II//Septum formation initiator//Protein of unknown function (DUF972)//SWI5-dependent HO expression protein 3//GrpE//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0007049//GO:0006260//GO:0006606//GO:0006355//GO:0006914//GO:0009405//GO:0019069//GO:0007155//GO:0016567//GO:0048309//GO:0051028//GO:0006457//GO:0006891 cell cycle//DNA replication//protein import into nucleus//regulation of transcription, DNA-templated//autophagy//pathogenesis//viral capsid assembly//cell adhesion//protein ubiquitination//endoplasmic reticulum inheritance//mRNA transport//protein folding//intra-Golgi vesicle-mediated transport GO:0003700//GO:0000774//GO:0043565//GO:0016881//GO:0051087//GO:0008134//GO:0045502//GO:0031386//GO:0042803 transcription factor activity, sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//sequence-specific DNA binding//acid-amino acid ligase activity//chaperone binding//transcription factor binding//dynein binding//protein tag//protein homodimerization activity GO:0030173//GO:0016020//GO:0005667//GO:0030286 integral component of Golgi membrane//membrane//transcription factor complex//dynein complex -- -- Cluster-8309.11554 BP_3 22.73 0.82 1632 332373436 AEE61859.1 1327 1.4e-143 unknown [Dendroctonus ponderosae] 572300323 XM_006616201.1 139 3.93407e-64 PREDICTED: Apis dorsata transmembrane protein 120 homolog (LOC102680574), mRNA -- -- -- -- Q9U1M2 1039 1.4e-111 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11555 BP_3 300.75 11.28 1577 332373436 AEE61859.1 1330 6.1e-144 unknown [Dendroctonus ponderosae] 572300323 XM_006616201.1 139 3.79858e-64 PREDICTED: Apis dorsata transmembrane protein 120 homolog (LOC102680574), mRNA -- -- -- -- Q9U1M2 1039 1.4e-111 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11556 BP_3 11.52 0.80 987 332373436 AEE61859.1 1027 5.2e-109 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9U1M2 845 2.7e-89 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11557 BP_3 722.01 10.58 3582 642920562 XP_001816430.2 1453 7.6e-158 PREDICTED: uncharacterized protein LOC100141961 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z0M5 495 3.8e-48 Lysosomal acid lipase/cholesteryl ester hydrolase OS=Mus musculus GN=Lipa PE=2 SV=2 PF01738//PF01764//PF04083 Dienelactone hydrolase family//Lipase (class 3)//Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.11564 BP_3 59.00 1.30 2473 642939658 XP_008201338.1 1593 3.1e-174 PREDICTED: pair-rule protein odd-paired-like [Tribolium castaneum]>gi|270015215|gb|EFA11663.1| hypothetical protein TcasGA2_TC010234 [Tribolium castaneum] -- -- -- -- -- K09225 ZIC4 zinc finger protein ZIC 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09225 P39768 992 6.2e-106 Pair-rule protein odd-paired OS=Drosophila melanogaster GN=opa PE=2 SV=2 PF01096//PF13465//PF00096//PF13912 Transcription factor S-II (TFIIS)//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger GO:0006351 transcription, DNA-templated GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005622 intracellular KOG1721 FOG: Zn-finger Cluster-8309.11565 BP_3 1.00 7.53 251 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11567 BP_3 9.40 0.49 1218 641660258 XP_008181429.1 814 3.2e-84 PREDICTED: uncharacterized protein LOC103308924 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.11569 BP_3 104.75 4.10 1522 328697775 XP_001946487.2 823 3.7e-85 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03849//PF01531//PF04827 Transcription factor Tfb2//Glycosyl transferase family 11//Plant transposon protein GO:0009247//GO:0006289//GO:0005975//GO:0001575 glycolipid biosynthetic process//nucleotide-excision repair//carbohydrate metabolic process//globoside metabolic process GO:0004003//GO:0008107//GO:0016788 ATP-dependent DNA helicase activity//galactoside 2-alpha-L-fucosyltransferase activity//hydrolase activity, acting on ester bonds GO:0016020//GO:0000439//GO:0005657//GO:0005634 membrane//core TFIIH complex//replication fork//nucleus -- -- Cluster-8309.11574 BP_3 314.00 4.06 4019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11576 BP_3 12.00 0.90 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11577 BP_3 7.00 0.99 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11578 BP_3 243.00 7.88 1778 642926429 XP_008191958.1 412 1.9e-37 PREDICTED: zinc finger protein Xfin-like [Tribolium castaneum]>gi|270008462|gb|EFA04910.1| hypothetical protein TcasGA2_TC014974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF15323 Zinc finger, C2H2 type//Developmental protein GO:0048598 embryonic morphogenesis GO:0046872 metal ion binding GO:0072669 tRNA-splicing ligase complex -- -- Cluster-8309.1158 BP_3 4.00 0.42 756 677369180 KFP96431.1 409 1.8e-37 Eukaryotic translation initiation factor 3 subunit B, partial [Leptosomus discolor] 768311754 CP010982.1 753 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence K03253 EIF3B translation initiation factor 3 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K03253 Q7S464 1030 7.4e-111 Eukaryotic translation initiation factor 3 subunit B OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=prt-1 PE=3 SV=1 PF00847 AP2 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2314 Translation initiation factor 3, subunit b (eIF-3b) Cluster-8309.11588 BP_3 2.79 4.42 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1159 BP_3 34.66 0.82 2317 189239672 XP_001813945.1 1598 7.6e-175 PREDICTED: serine proteinase stubble [Tribolium castaneum]>gi|270011208|gb|EFA07656.1| hypothetical protein TcasGA2_TC030609 [Tribolium castaneum] 642930385 XM_001813893.2 321 3.77233e-165 PREDICTED: Tribolium castaneum serine proteinase stubble (LOC662802), mRNA -- -- -- -- Q05319 650 2.6e-66 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089//PF00548 Trypsin//3C cysteine protease (picornain 3C) GO:0006508 proteolysis GO:0004197//GO:0004252 cysteine-type endopeptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.11591 BP_3 13.05 0.64 1273 499140776 AGL76355.1 281 2.2e-22 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 254 1.2e-20 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF04977//PF05531//PF02689 Septum formation initiator//Nucleopolyhedrovirus P10 protein//Helicase GO:0007049 cell cycle GO:0004386//GO:0005524 helicase activity//ATP binding GO:0019028 viral capsid -- -- Cluster-8309.11592 BP_3 2.00 12.24 257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11593 BP_3 4.00 0.31 906 195109038 XP_001999097.1 721 1.5e-73 GI24325 [Drosophila mojavensis]>gi|193915691|gb|EDW14558.1| GI24325 [Drosophila mojavensis] 768419111 XM_011551956.1 37 1.08063e-07 PREDICTED: Plutella xylostella acyl-CoA Delta(11) desaturase-like (LOC105382122), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 Q6US81 594 3.2e-60 Acyl-CoA Delta(11) desaturase OS=Spodoptera littoralis PE=1 SV=1 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process GO:0016491 oxidoreductase activity -- -- KOG1600 Fatty acid desaturase Cluster-8309.11596 BP_3 20.00 8.08 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11602 BP_3 4.00 1.24 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11603 BP_3 1.00 22.75 223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11604 BP_3 78.90 0.83 4885 642912709 XP_008200970.1 3209 0.0e+00 PREDICTED: PDZ domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NEN9 524 2.3e-51 PDZ domain-containing protein 8 OS=Homo sapiens GN=PDZD8 PE=1 SV=1 PF00595//PF01484//PF13180//PF00130//PF04689 PDZ domain (Also known as DHR or GLGF)//Nematode cuticle collagen N-terminal domain//PDZ domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//DNA binding protein S1FA GO:0035556//GO:0006355 intracellular signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0042302//GO:0003677 protein binding//structural constituent of cuticle//DNA binding GO:0005634 nucleus KOG3532 Predicted protein kinase Cluster-8309.11608 BP_3 73.29 2.33 1811 642919863 XP_008192100.1 1129 1.4e-120 PREDICTED: mitochondrial ribonuclease P protein 3 [Tribolium castaneum] -- -- -- -- -- K17655 MRPP3 mitochondrial ribonuclease P protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17655 Q8JZY4 534 5.8e-53 Mitochondrial ribonuclease P protein 3 OS=Mus musculus GN=Kiaa0391 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1161 BP_3 20.00 1.04 1218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11610 BP_3 11.00 0.54 1278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11613 BP_3 26.00 1.23 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11616 BP_3 40.97 0.41 5163 546670638 ERL83322.1 433 2.1e-39 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11617 BP_3 60.13 1.13 2866 546670638 ERL83322.1 459 1.1e-42 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11621 BP_3 4.00 0.92 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.11628 BP_3 10.16 0.54 1194 91079476 XP_967809.1 269 5.0e-21 PREDICTED: cytochrome b5 [Tribolium castaneum]>gi|270003450|gb|EEZ99897.1| hypothetical protein TcasGA2_TC002681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0046872//GO:0020037 metal ion binding//heme binding -- -- KOG0537 Cytochrome b5 Cluster-8309.11631 BP_3 5.00 0.45 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11632 BP_3 4.00 0.31 909 449273738 EMC83152.1 140 3.4e-06 hypothetical protein A306_08766, partial [Columba livia] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.11638 BP_3 47.69 0.57 4313 642923343 XP_008193710.1 3009 0.0e+00 PREDICTED: homeotic protein spalt-major-like isoform X1 [Tribolium castaneum]>gi|270008162|gb|EFA04610.1| spalt [Tribolium castaneum] 817074280 XM_012403900.1 143 6.29436e-66 PREDICTED: Athalia rosae homeotic protein spalt-major-like (LOC105687921), mRNA -- -- -- -- P39770 661 2.6e-67 Homeotic protein spalt-major OS=Drosophila melanogaster GN=salm PE=1 SV=3 PF16622//PF13912//PF00096//PF13465 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.11639 BP_3 17.36 0.74 1424 510853298 EPB69401.1 216 8.3e-15 transposase, IS4 family [Ancylostoma ceylanicum] -- -- -- -- -- -- -- -- -- Q96DM1 150 1.5e-08 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1164 BP_3 2.00 0.49 490 861619085 KMQ86945.1 259 2.9e-20 hypothetical protein RF55_13929 [Lasius niger]>gi|861619153|gb|KMQ86961.1| hypothetical protein RF55_13908 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01771 Herpesvirus alkaline exonuclease -- -- GO:0003677//GO:0004527 DNA binding//exonuclease activity -- -- -- -- Cluster-8309.11645 BP_3 48.10 0.77 3303 768432767 XP_011557722.1 148 1.5e-06 PREDICTED: uncharacterized protein LOC105388496 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11647 BP_3 22.03 1.15 1215 642935674 XP_974741.2 529 3.6e-51 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9S1 419 8.4e-40 Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Drosophila melanogaster GN=blos1 PE=1 SV=2 PF06320 GCN5-like protein 1 (GCN5L1) -- -- -- -- GO:0031083 BLOC-1 complex KOG3390 General control of amino-acid synthesis 5-like 1 Cluster-8309.11649 BP_3 101.00 8.04 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11650 BP_3 19.00 10.54 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11651 BP_3 4.09 0.37 819 117558776 AAI27396.1 216 4.8e-15 Zgc:153686 [Danio rerio] 388571221 JN184773.1 74 2.62932e-28 Ostrea edulis ubiquitin mRNA, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 P0CG65 204 4.8e-15 Polyubiquitin-B OS=Pan troglodytes GN=UBB PE=3 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.11656 BP_3 29.82 0.81 2076 91078434 XP_974803.1 577 1.7e-56 PREDICTED: uncharacterized protein LOC663674 isoform X1 [Tribolium castaneum]>gi|270003869|gb|EFA00317.1| hypothetical protein TcasGA2_TC003155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08445//PF13673//PF13302//PF00583 FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.11657 BP_3 12.04 0.69 1129 546673528 ERL85111.1 166 4.1e-09 hypothetical protein D910_02533 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11658 BP_3 26.04 0.76 1938 642913447 XP_008201016.1 1386 2.4e-150 PREDICTED: transmembrane protease serine 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY7 468 2.8e-45 Ovochymase-1 OS=Homo sapiens GN=OVCH1 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.11659 BP_3 1059.96 43.47 1467 642913447 XP_008201016.1 1391 4.8e-151 PREDICTED: transmembrane protease serine 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 468 2.1e-45 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.1166 BP_3 5.00 0.69 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11662 BP_3 128.50 6.48 1247 91087801 XP_967436.1 1166 5.0e-125 PREDICTED: 39S ribosomal protein L39, mitochondrial [Tribolium castaneum]>gi|270010754|gb|EFA07202.1| hypothetical protein TcasGA2_TC010209 [Tribolium castaneum] -- -- -- -- -- K17420 MRPL39 large subunit ribosomal protein L39 http://www.genome.jp/dbget-bin/www_bget?ko:K17420 Q9VUJ0 746 1.0e-77 39S ribosomal protein L39, mitochondrial OS=Drosophila melanogaster GN=mRpL39 PE=1 SV=2 -- -- -- -- GO:0000166 nucleotide binding -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.11666 BP_3 75.00 3.16 1435 676495165 XP_009066800.1 170 1.8e-09 hypothetical protein LOTGIDRAFT_176281 [Lottia gigantea]>gi|556093859|gb|ESO82512.1| hypothetical protein LOTGIDRAFT_176281 [Lottia gigantea] 768311755 CP010983.1 1435 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- PF02948 Amelogenin GO:0007275 multicellular organismal development -- -- GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.11667 BP_3 4.00 2.88 354 -- -- -- -- -- 768311755 CP010983.1 345 2.4185e-179 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11670 BP_3 6.10 0.34 1161 478252909 ENN73293.1 245 2.9e-18 hypothetical protein YQE_10057, partial [Dendroctonus ponderosae] -- -- -- -- -- K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 Q925N3 209 1.8e-15 PEX5-related protein OS=Rattus norvegicus GN=Pex5l PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1125 TPR repeat-containing protein Cluster-8309.11672 BP_3 40.28 0.32 6282 612026501 XP_007492212.1 603 4.9e-59 PREDICTED: zinc finger protein 91-like [Monodelphis domestica] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NYT6 585 2.5e-58 Zinc finger protein 226 OS=Homo sapiens GN=ZNF226 PE=2 SV=2 PF02053//PF00130//PF00096//PF13465//PF13912 Gene 66 (IR5) protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger GO:0035556 intracellular signal transduction GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.11673 BP_3 74.83 7.05 803 546684931 ERL94513.1 553 3.9e-54 hypothetical protein D910_11790 [Dendroctonus ponderosae] -- -- -- -- -- K17429 MRPL48 large subunit ribosomal protein L48 http://www.genome.jp/dbget-bin/www_bget?ko:K17429 Q2YDI5 203 6.2e-15 39S ribosomal protein L48, mitochondrial OS=Bos taurus GN=MRPL48 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4060 Uncharacterized conserved protein Cluster-8309.11675 BP_3 37.00 2.47 1014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11676 BP_3 3.00 0.76 482 820997375 XP_004647393.2 673 2.9e-68 PREDICTED: 60S ribosomal protein L27a-like [Octodon degus] 675746405 XM_003818132.2 482 0 PREDICTED: Pan paniscus ribosomal protein L27a (RPL27A), mRNA K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 Q5REY2 677 4.0e-70 60S ribosomal protein L27a OS=Pongo abelii GN=RPL27A PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1742 60s ribosomal protein L15/L27 Cluster-8309.11677 BP_3 8.67 0.79 821 546678918 ERL89456.1 270 2.6e-21 hypothetical protein D910_06823 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05715//PF00096 Piccolo Zn-finger//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0045202 synapse -- -- Cluster-8309.1168 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11680 BP_3 11.19 0.52 1323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11683 BP_3 26.00 5.01 542 -- -- -- -- -- 697090972 XM_009660015.1 493 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11689 BP_3 49.94 4.12 876 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02259 FAT domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.1169 BP_3 54.00 1.20 2455 158296370 XP_316784.4 167 6.9e-09 AGAP000820-PA [Anopheles gambiae str. PEST]>gi|157015264|gb|EAA43983.4| AGAP000820-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11690 BP_3 101.00 2.07 2645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11691 BP_3 76.93 1.98 2161 642929412 XP_008195828.1 2366 6.2e-264 PREDICTED: uncharacterized protein LOC663405 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11696 BP_3 109.00 9.74 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1170 BP_3 3.00 0.94 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11701 BP_3 10.00 1.59 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11704 BP_3 46.03 0.82 2997 546684809 ERL94391.1 2055 1.0e-227 hypothetical protein D910_11670 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q92832 910 2.4e-96 Protein kinase C-binding protein NELL1 OS=Homo sapiens GN=NELL1 PE=1 SV=4 PF00008//PF07645//PF00093 EGF-like domain//Calcium-binding EGF domain//von Willebrand factor type C domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.1171 BP_3 7.00 0.31 1374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05868//PF00812 Rotavirus major outer capsid protein VP7//Ephrin -- -- -- -- GO:0016020//GO:0016021//GO:0019012 membrane//integral component of membrane//virion -- -- Cluster-8309.11714 BP_3 29150.00 1947.99 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11718 BP_3 25.58 0.95 1590 478259252 ENN79154.1 446 2.0e-41 hypothetical protein YQE_04340, partial [Dendroctonus ponderosae]>gi|546678412|gb|ERL89035.1| hypothetical protein D910_06413 [Dendroctonus ponderosae] -- -- -- -- -- K03193 UST dermatan/chondrotin sulfate uronyl 2-O-sulfotransferase UST http://www.genome.jp/dbget-bin/www_bget?ko:K03193 Q9Y2C2 174 2.8e-11 Uronyl 2-sulfotransferase OS=Homo sapiens GN=UST PE=2 SV=1 PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.11720 BP_3 10.98 0.73 1020 642916792 XP_008199505.1 842 1.5e-87 PREDICTED: deformed epidermal autoregulatory factor 1 [Tribolium castaneum]>gi|270003059|gb|EEZ99506.1| hypothetical protein TcasGA2_TC000085 [Tribolium castaneum] 642916791 XM_008201283.1 117 4.12366e-52 PREDICTED: Tribolium castaneum deformed epidermal autoregulatory factor 1 (LOC655086), mRNA -- -- -- -- Q9Z1T5 286 1.9e-24 Deformed epidermal autoregulatory factor 1 homolog OS=Mus musculus GN=Deaf1 PE=1 SV=1 PF01342 SAND domain -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.11721 BP_3 23.54 0.67 1993 642122061 CDQ63792.1 197 1.9e-12 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14372//PF02083 Domain of unknown function (DUF4413)//Urotensin II GO:0007165//GO:0042312//GO:0008217 signal transduction//regulation of vasodilation//regulation of blood pressure GO:0005179//GO:0003677 hormone activity//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.11725 BP_3 112.00 38.04 433 642914741 XP_008190333.1 475 2.3e-45 PREDICTED: U6 snRNA-associated Sm-like protein LSm2 [Tribolium castaneum]>gi|270001426|gb|EEZ97873.1| hypothetical protein TcasGA2_TC000255 [Tribolium castaneum] 585667812 XM_002735395.2 111 3.62229e-49 PREDICTED: Saccoglossus kowalevskii U6 snRNA-associated Sm-like protein LSm2-like (LOC100371976), mRNA K12621 LSM2 U6 snRNA-associated Sm-like protein LSm2 http://www.genome.jp/dbget-bin/www_bget?ko:K12621 Q9Y333 448 1.3e-43 U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens GN=LSM2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3448 Predicted snRNP core protein Cluster-8309.11726 BP_3 14.08 0.47 1748 642936637 XP_008198518.1 937 2.5e-98 PREDICTED: zinc finger and BTB domain-containing protein 12 [Tribolium castaneum] 642936636 XM_008200296.1 81 7.36744e-32 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 12 (LOC661906), mRNA -- -- -- -- Q01295 398 3.3e-37 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.1173 BP_3 24.01 1.67 986 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11735 BP_3 193.46 1.34 7269 242005002 XP_002423364.1 1264 1.3e-135 hormone receptor hr3, putative [Pediculus humanus corporis]>gi|212506394|gb|EEB10626.1| hormone receptor hr3, putative [Pediculus humanus corporis] 642929407 XM_008197603.1 666 0 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X3, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P31396 730 4.4e-75 Probable nuclear hormone receptor HR3 OS=Drosophila melanogaster GN=Hr46 PE=2 SV=1 PF00104 Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355//GO:0009987 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//cellular process GO:0005488 binding -- -- -- -- Cluster-8309.11739 BP_3 43.47 0.34 6470 546680884 ERL91070.1 2108 1.5e-233 hypothetical protein D910_08412 [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 Q6RI45 1277 1.5e-138 Bromodomain and WD repeat-containing protein 3 OS=Homo sapiens GN=BRWD3 PE=1 SV=2 PF10717//PF13417//PF02798//PF00439//PF06507//PF13409//PF00400 Occlusion-derived virus envelope protein ODV-E18//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Bromodomain//Auxin response factor//Glutathione S-transferase, N-terminal domain//WD domain, G-beta repeat GO:0006355//GO:0009725 regulation of transcription, DNA-templated//response to hormone GO:0005515//GO:0003677 protein binding//DNA binding GO:0019031//GO:0005634 viral envelope//nucleus -- -- Cluster-8309.11741 BP_3 32.22 0.39 4280 642923317 XP_008193699.1 896 3.5e-93 PREDICTED: PQ-loop repeat-containing protein 1 isoform X1 [Tribolium castaneum] 462316717 APGK01044976.1 64 5.14572e-22 Dendroctonus ponderosae Seq01044986, whole genome shotgun sequence -- -- -- -- Q6NRS2 500 1.2e-48 PQ-loop repeat-containing protein 1 OS=Xenopus laevis GN=pqlc1 PE=2 SV=1 PF00810//PF02383 ER lumen protein retaining receptor//SacI homology domain GO:0006621 protein retention in ER lumen GO:0046923//GO:0042578 ER retention sequence binding//phosphoric ester hydrolase activity GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane -- -- Cluster-8309.11742 BP_3 539.40 9.40 3059 642923319 XP_008193700.1 1100 5.6e-117 PREDICTED: PQ-loop repeat-containing protein 1 isoform X2 [Tribolium castaneum]>gi|270007615|gb|EFA04063.1| hypothetical protein TcasGA2_TC014297 [Tribolium castaneum] 462316717 APGK01044976.1 64 3.66529e-22 Dendroctonus ponderosae Seq01044986, whole genome shotgun sequence -- -- -- -- Q0VCC1 679 1.5e-69 PQ-loop repeat-containing protein 1 OS=Bos taurus GN=PQLC1 PE=2 SV=1 PF03083//PF00810 Sugar efflux transporter for intercellular exchange//ER lumen protein retaining receptor GO:0006621 protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG2913 Predicted membrane protein Cluster-8309.11743 BP_3 30.73 0.33 4842 642923319 XP_008193700.1 631 2.1e-62 PREDICTED: PQ-loop repeat-containing protein 1 isoform X2 [Tribolium castaneum]>gi|270007615|gb|EFA04063.1| hypothetical protein TcasGA2_TC014297 [Tribolium castaneum] 462316717 APGK01044976.1 64 5.82713e-22 Dendroctonus ponderosae Seq01044986, whole genome shotgun sequence -- -- -- -- Q6NRS2 415 9.8e-39 PQ-loop repeat-containing protein 1 OS=Xenopus laevis GN=pqlc1 PE=2 SV=1 PF00810 ER lumen protein retaining receptor GO:0006621 protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG2913 Predicted membrane protein Cluster-8309.11747 BP_3 72.00 3.33 1333 91090270 XP_970541.1 1233 9.2e-133 PREDICTED: uncharacterized protein LOC659116 [Tribolium castaneum]>gi|270013787|gb|EFA10235.1| hypothetical protein TcasGA2_TC012432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11749 BP_3 43.30 1.00 2372 160333791 NP_001103907.1 2126 4.6e-236 eyeless [Tribolium castaneum]>gi|158187657|gb|ABW23132.1| eyeless [Tribolium castaneum] 820837347 XM_012493950.1 167 1.56704e-79 PREDICTED: Apis florea paired box protein Pax-6-like (LOC100870332), mRNA K08031 PAX6 paired box protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08031 P26630 1171 1.0e-126 Paired box protein Pax-6 OS=Danio rerio GN=pax6a PE=2 SV=1 PF05920//PF00292//PF00046 Homeobox KN domain//'Paired box' domain//Homeobox domain GO:0006355//GO:0007275 regulation of transcription, DNA-templated//multicellular organismal development GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains Cluster-8309.11752 BP_3 11.00 1.92 568 -- -- -- -- -- 642938317 XM_962607.3 43 3.05717e-11 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11758 BP_3 481.03 27.53 1134 546686178 ERL95558.1 372 5.4e-33 hypothetical protein D910_12819 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1176 BP_3 1.00 11.75 239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11767 BP_3 24.28 0.96 1508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11768 BP_3 1.00 2.22 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11772 BP_3 9.00 29.69 277 768436073 XP_011559502.1 166 1.0e-09 PREDICTED: mucin-19-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11774 BP_3 14.89 0.31 2632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11775 BP_3 5.55 0.49 834 189239951 XP_001812757.1 545 3.4e-53 PREDICTED: kinase suppressor of Ras 2 isoform X1 [Tribolium castaneum]>gi|270011828|gb|EFA08276.1| hypothetical protein TcasGA2_TC005910 [Tribolium castaneum] -- -- -- -- -- K18529 KSR2 kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18529 Q6VAB6 135 4.9e-07 Kinase suppressor of Ras 2 OS=Homo sapiens GN=KSR2 PE=1 SV=2 PF07649//PF00130//PF01093 C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Clusterin GO:0035556//GO:0055114//GO:0008219//GO:0009069//GO:0006468//GO:0016310 intracellular signal transduction//oxidation-reduction process//cell death//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004674//GO:0047134//GO:0046872//GO:0005524 protein serine/threonine kinase activity//protein-disulfide reductase activity//metal ion binding//ATP binding GO:0005622 intracellular -- -- Cluster-8309.1178 BP_3 32.01 0.39 4257 91082043 XP_971088.1 4311 0.0e+00 PREDICTED: neuroligin-4, X-linked [Tribolium castaneum] 642921979 XM_965995.2 808 0 PREDICTED: Tribolium castaneum neuroligin 4 (LOC659717), mRNA K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N2Q7 989 2.4e-105 Neuroligin-1 OS=Homo sapiens GN=NLGN1 PE=1 SV=2 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.11791 BP_3 120.29 0.53 11259 270002715 EEZ99162.1 7116 0.0e+00 hypothetical protein TcasGA2_TC016161 [Tribolium castaneum] -- -- -- -- -- K06642 PRKDC DNA-dependent protein kinase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06642 Q9DEI1 1179 5.8e-127 DNA-dependent protein kinase catalytic subunit OS=Xenopus laevis GN=prkdc PE=2 SV=1 PF02260//PF00454//PF08163//PF08030 FATC domain//Phosphatidylinositol 3- and 4-kinase//NUC194 domain//Ferric reductase NAD binding domain GO:0016310//GO:0006303//GO:0009069//GO:0055114 phosphorylation//double-strand break repair via nonhomologous end joining//serine family amino acid metabolic process//oxidation-reduction process GO:0005515//GO:0016491//GO:0003677//GO:0004677//GO:0005524//GO:0016773 protein binding//oxidoreductase activity//DNA binding//DNA-dependent protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0891 DNA-dependent protein kinase Cluster-8309.11797 BP_3 1.00 0.85 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11799 BP_3 143.69 3.00 2604 91081993 XP_969039.1 1700 1.3e-186 PREDICTED: KDEL motif-containing protein 1 [Tribolium castaneum]>gi|270007375|gb|EFA03823.1| hypothetical protein TcasGA2_TC013938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UW63 1169 1.9e-126 KDEL motif-containing protein 1 OS=Homo sapiens GN=KDELC1 PE=1 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.11800 BP_3 35.14 0.73 2617 91081993 XP_969039.1 1700 1.3e-186 PREDICTED: KDEL motif-containing protein 1 [Tribolium castaneum]>gi|270007375|gb|EFA03823.1| hypothetical protein TcasGA2_TC013938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UW63 1169 2.0e-126 KDEL motif-containing protein 1 OS=Homo sapiens GN=KDELC1 PE=1 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.11803 BP_3 1.00 1.35 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11805 BP_3 200.31 12.44 1068 91080425 XP_968280.1 1012 3.1e-107 PREDICTED: transmembrane protein 147 [Tribolium castaneum]>gi|270005752|gb|EFA02200.1| hypothetical protein TcasGA2_TC007856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DFI2 627 5.6e-64 Transmembrane protein 147 OS=Xenopus laevis GN=tmem147 PE=2 SV=1 PF15009 Transmembrane protein 173 GO:0032481//GO:0002218 positive regulation of type I interferon production//activation of innate immune response -- -- -- -- KOG3236 Predicted membrane protein Cluster-8309.11807 BP_3 143.88 5.31 1597 751215591 XP_011160707.1 146 1.2e-06 PREDICTED: DNA ligase 1-like [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01015//PF06374 Ribosomal S3Ae family//NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006744//GO:0006814//GO:0042254//GO:0015992//GO:0006120//GO:0006412 ubiquinone biosynthetic process//sodium ion transport//ribosome biogenesis//proton transport//mitochondrial electron transport, NADH to ubiquinone//translation GO:0003735//GO:0008137 structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity GO:0005622//GO:0005840//GO:0005743 intracellular//ribosome//mitochondrial inner membrane -- -- Cluster-8309.1181 BP_3 3.00 0.58 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11810 BP_3 1.00 0.74 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11811 BP_3 35.74 1.14 1804 642925584 XP_008194609.1 831 5.1e-86 PREDICTED: LOW QUALITY PROTEIN: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11814 BP_3 20.41 0.97 1305 642919381 XP_008191848.1 585 1.2e-57 PREDICTED: vascular endothelial growth factor receptor 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 Q8AXC7 339 1.7e-30 Platelet-derived growth factor receptor alpha OS=Takifugu rubripes GN=pdgfra PE=3 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.11815 BP_3 14.23 1.20 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1182 BP_3 29.59 0.59 2708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11827 BP_3 368.86 6.31 3111 642934662 XP_008197757.1 2210 1.1e-245 PREDICTED: partitioning defective 3 homolog isoform X4 [Tribolium castaneum] 766917723 XM_011496118.1 51 6.28313e-15 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 635 1.9e-64 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.11828 BP_3 62.46 0.92 3551 642926332 XP_968832.2 2936 0.0e+00 PREDICTED: RING finger protein 207 isoform X2 [Tribolium castaneum] 642926333 XM_008196659.1 246 2.85992e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 670 1.9e-68 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF04513//PF16685//PF04673//PF13639//PF04728//PF06005//PF00643//PF14634//PF00097 Baculovirus polyhedron envelope protein, PEP, C terminus//zinc RING finger of MSL2//Polyketide synthesis cyclase//Ring finger domain//Lipoprotein leucine-zipper//Protein of unknown function (DUF904)//B-box zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) GO:0030639//GO:0000917//GO:0043093 polyketide biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis GO:0061630//GO:0005198//GO:0005515//GO:0046872//GO:0008270 ubiquitin protein ligase activity//structural molecule activity//protein binding//metal ion binding//zinc ion binding GO:0019031//GO:0019028//GO:0019867//GO:0005737//GO:0005622 viral envelope//viral capsid//outer membrane//cytoplasm//intracellular -- -- Cluster-8309.11834 BP_3 844.73 12.93 3440 270005279 EFA01727.1 280 7.6e-22 hypothetical protein TcasGA2_TC007307 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11835 BP_3 3.00 0.80 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11839 BP_3 91.00 3.63 1500 642931703 XP_966917.2 1061 9.1e-113 PREDICTED: GTPase Era, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X2B8 587 3.4e-59 GTPase Era, mitochondrial OS=Salmo salar GN=eral1 PE=2 SV=1 PF00025//PF02421//PF01926//PF00735//PF08477//PF00071//PF04548//PF10662//PF02263//PF00503//PF03193//PF00005 ADP-ribosylation factor family//Ferrous iron transport protein B//50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//Ras family//AIG1 family//Ethanolamine utilisation - propanediol utilisation//Guanylate-binding protein, N-terminal domain//G-protein alpha subunit//Protein of unknown function, DUF258//ABC transporter GO:0007165//GO:0006576//GO:0015684//GO:0007264//GO:0007186 signal transduction//cellular biogenic amine metabolic process//ferrous iron transport//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0015093//GO:0005524//GO:0016887//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//ferrous iron transmembrane transporter activity//ATP binding//ATPase activity//guanyl nucleotide binding//signal transducer activity//GTP binding GO:0016021 integral component of membrane KOG1423 Ras-like GTPase ERA Cluster-8309.11841 BP_3 52.72 0.91 3069 642922398 XP_008193141.1 2127 4.6e-236 PREDICTED: adenylate kinase isoenzyme 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y6K8 307 2.1e-26 Adenylate kinase isoenzyme 5 OS=Homo sapiens GN=AK5 PE=1 SV=2 PF09107//PF00004 Elongation factor SelB, winged helix//ATPase family associated with various cellular activities (AAA) GO:0006448//GO:0001514 regulation of translational elongation//selenocysteine incorporation GO:0005524//GO:0003723//GO:0005525//GO:0003746 ATP binding//RNA binding//GTP binding//translation elongation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG3079 Uridylate kinase/adenylate kinase Cluster-8309.11844 BP_3 9.00 0.97 739 642924778 XP_008194436.1 448 5.4e-42 PREDICTED: U6 snRNA-associated Sm-like protein LSm4 [Tribolium castaneum] 840425550 LK065217.1 62 1.10644e-21 Apteryx australis mantelli genome assembly AptMant0, scaffold scaffold645 K12623 LSM4 U6 snRNA-associated Sm-like protein LSm4 http://www.genome.jp/dbget-bin/www_bget?ko:K12623 Q9Y4Z0 369 3.2e-34 U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens GN=LSM4 PE=1 SV=1 PF10384 Centromere protein Scm3 -- -- GO:0042393 histone binding GO:0005634 nucleus KOG3293 Small nuclear ribonucleoprotein (snRNP) Cluster-8309.11847 BP_3 237.00 14.47 1081 478249757 ENN70265.1 397 6.5e-36 hypothetical protein YQE_13048, partial [Dendroctonus ponderosae]>gi|546677437|gb|ERL88274.1| hypothetical protein D910_05661 [Dendroctonus ponderosae] 665793661 XM_008546266.1 101 3.43323e-43 PREDICTED: Microplitis demolitor U6 snRNA-associated Sm-like protein LSm6 (LOC103569138), mRNA K12625 LSM6 U6 snRNA-associated Sm-like protein LSm6 http://www.genome.jp/dbget-bin/www_bget?ko:K12625 P62313 344 3.7e-31 U6 snRNA-associated Sm-like protein LSm6 OS=Mus musculus GN=Lsm6 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1783 Small nuclear ribonucleoprotein F Cluster-8309.11851 BP_3 154.85 4.08 2121 642935034 XP_008199914.1 150 5.6e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 198 8.18336e-97 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF04111//PF03938//PF05835//PF02841//PF10186 Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Synaphin protein//Guanylate-binding protein, C-terminal domain//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508//GO:0006914//GO:0006836 positive regulation of autophagy//autophagy//neurotransmitter transport GO:0003924//GO:0019905//GO:0051082//GO:0005525 GTPase activity//syntaxin binding//unfolded protein binding//GTP binding -- -- -- -- Cluster-8309.11858 BP_3 3.00 0.58 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1186 BP_3 36.90 2.46 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.11866 BP_3 89.74 3.21 1638 91079414 XP_967324.1 1768 1.0e-194 PREDICTED: iduronate 2-sulfatase [Tribolium castaneum]>gi|270004379|gb|EFA00827.1| hypothetical protein TcasGA2_TC003715 [Tribolium castaneum] -- -- -- -- -- K01136 IDS iduronate 2-sulfatase http://www.genome.jp/dbget-bin/www_bget?ko:K01136 Q08890 1190 4.5e-129 Iduronate 2-sulfatase OS=Mus musculus GN=Ids PE=2 SV=3 PF00884//PF01676//PF01663 Sulfatase//Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824//GO:0046872 sulfuric ester hydrolase activity//catalytic activity//metal ion binding -- -- -- -- Cluster-8309.11875 BP_3 2.00 0.91 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1188 BP_3 50.94 3.71 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.11883 BP_3 1.00 0.74 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11887 BP_3 24.98 5.98 493 642915266 XP_971845.3 424 2.2e-39 PREDICTED: sorting nexin-16 [Tribolium castaneum]>gi|270003912|gb|EFA00360.1| hypothetical protein TcasGA2_TC003202 [Tribolium castaneum] -- -- -- -- -- K17928 SNX16 sorting nexin-16 http://www.genome.jp/dbget-bin/www_bget?ko:K17928 P57768 200 8.4e-15 Sorting nexin-16 OS=Homo sapiens GN=SNX16 PE=1 SV=2 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- -- -- Cluster-8309.11888 BP_3 32.00 9.90 447 646716106 KDR19493.1 157 1.8e-08 Cytochrome c oxidase subunit 7A-related protein, mitochondrial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P13184 128 1.7e-06 Cytochrome c oxidase subunit 7A2, mitochondrial OS=Bos taurus GN=COX7A2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11892 BP_3 22.51 0.40 2974 817199200 XP_012275275.1 876 5.1e-91 PREDICTED: 4-hydroxyphenylpyruvate dioxygenase [Orussus abietinus] -- -- -- -- -- K00457 HPD, hppD 4-hydroxyphenylpyruvate dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00457 P32755 766 1.2e-79 4-hydroxyphenylpyruvate dioxygenase OS=Rattus norvegicus GN=Hpd PE=1 SV=3 PF02050//PF00631 Flagellar FliJ protein//GGL domain GO:0007186//GO:0006935//GO:0007165//GO:0071973 G-protein coupled receptor signaling pathway//chemotaxis//signal transduction//bacterial-type flagellum-dependent cell motility GO:0003774//GO:0004871 motor activity//signal transducer activity GO:0016020//GO:0009288//GO:0005834 membrane//bacterial-type flagellum//heterotrimeric G-protein complex KOG0638 4-hydroxyphenylpyruvate dioxygenase Cluster-8309.11894 BP_3 56.81 1.17 2623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11896 BP_3 410.89 8.79 2546 148469572 ABQ65715.1 2293 2.1e-255 putative arylphorin-like hexameric storage protein [Anoplophora glabripennis] 332376936 BT128651.1 62 3.93956e-21 Dendroctonus ponderosae clone DPO1134_A18 unknown mRNA -- -- -- -- Q17127 1174 5.0e-127 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 PF10541//PF12464 Nuclear envelope localisation domain//Maltose acetyltransferase GO:0042967 acyl-carrier-protein biosynthetic process GO:0016407 acetyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.11898 BP_3 200.41 37.68 548 91093274 XP_971370.1 589 1.8e-58 PREDICTED: U6 snRNA-associated Sm-like protein LSm1 [Tribolium castaneum]>gi|270016827|gb|EFA13273.1| hypothetical protein TcasGA2_TC001544 [Tribolium castaneum] -- -- -- -- -- K12620 LSM1 U6 snRNA-associated Sm-like protein LSm1 http://www.genome.jp/dbget-bin/www_bget?ko:K12620 Q5E9Z8 413 1.9e-39 U6 snRNA-associated Sm-like protein LSm1 OS=Bos taurus GN=LSM1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1782 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.1190 BP_3 12.31 0.84 995 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.11904 BP_3 24.45 1.14 1330 642936729 XP_008198556.1 318 1.2e-26 PREDICTED: uncharacterized protein LOC103314384 [Tribolium castaneum]>gi|270000961|gb|EEZ97408.1| hypothetical protein TcasGA2_TC011237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11908 BP_3 32.00 1.15 1638 752866839 XP_011269926.1 154 1.5e-07 PREDICTED: uncharacterized protein LOC105259591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006813//GO:0006814 potassium ion transport//sodium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.11912 BP_3 1.00 0.33 438 470306868 XP_004363510.1 398 2.0e-36 vacuolar protein sorting-associated protein Vps35 [Capsaspora owczarzaki ATCC 30864]>gi|765552276|gb|KJE92897.1| vacuolar protein sorting-associated protein Vps35 [Capsaspora owczarzaki ATCC 30864] 697085217 XM_009657227.1 435 0 Verticillium dahliae VdLs.17 vacuolar protein sorting-associated protein partial mRNA K18468 VPS35 vacuolar protein sorting-associated protein 35 http://www.genome.jp/dbget-bin/www_bget?ko:K18468 P34110 420 2.3e-40 Vacuolar protein sorting-associated protein 35 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS35 PE=1 SV=2 PF03635 Vacuolar protein sorting-associated protein 35 GO:0015031//GO:0042147 protein transport//retrograde transport, endosome to Golgi GO:0008565 protein transporter activity GO:0030904 retromer complex KOG1107 Membrane coat complex Retromer, subunit VPS35 Cluster-8309.11913 BP_3 30.82 0.54 3035 91077232 XP_968256.1 2161 5.2e-240 PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|642913746|ref|XP_008201143.1| PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|270002085|gb|EEZ98532.1| hypothetical protein TcasGA2_TC001036 [Tribolium castaneum] 780675948 XM_011698114.1 402 0 PREDICTED: Wasmannia auropunctata fizzy-related protein homolog (LOC105455066), mRNA K03364 CDH1 cell division cycle 20-like protein 1, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03364 Q9R1K5 1593 1.5e-175 Fizzy-related protein homolog OS=Mus musculus GN=Fzr1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.1192 BP_3 58.00 1.16 2707 641666055 XP_008183596.1 556 5.9e-54 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09229 ZKSCAN KRAB and SCAN domains-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09229 Q9EQB9 517 8.1e-51 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF13465//PF00096//PF13912//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.11920 BP_3 212.66 1.98 5459 91082933 XP_972996.1 747 8.5e-76 PREDICTED: uncharacterized protein LOC661762 [Tribolium castaneum]>gi|270007056|gb|EFA03504.1| hypothetical protein TcasGA2_TC013505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11924 BP_3 37.93 0.58 3445 755945580 XP_011299844.1 1088 1.5e-115 PREDICTED: basic proline-rich protein-like [Fopius arisanus]>gi|755945583|ref|XP_011299845.1| PREDICTED: basic proline-rich protein-like [Fopius arisanus] -- -- -- -- -- -- -- -- -- Q04118 217 6.3e-16 Basic salivary proline-rich protein 3 OS=Homo sapiens GN=PRB3 PE=1 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.11928 BP_3 76.00 3.31 1400 642921808 XP_008199328.1 1335 1.4e-144 PREDICTED: protein vestigial [Tribolium castaneum] 451810339 AB698923.1 395 0 Tenebrio molitor vg mRNA for vestigial, partial cds -- -- -- -- Q26366 342 8.2e-31 Protein vestigial OS=Drosophila melanogaster GN=vg PE=1 SV=1 PF07545 Vestigial/Tondu family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.1193 BP_3 5.00 0.55 731 642925202 XP_008194466.1 231 7.8e-17 PREDICTED: uncharacterized protein LOC103313298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11933 BP_3 7.00 0.40 1128 -- -- -- -- -- 462316329 APGK01045114.1 48 1.04067e-13 Dendroctonus ponderosae Seq01045124, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11935 BP_3 45.83 0.43 5449 170037792 XP_001846739.1 268 3.0e-20 zinc finger protein 1 [Culex quinquefasciatus]>gi|167881143|gb|EDS44526.1| zinc finger protein 1 [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- Q9CXE0 229 4.1e-17 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF00096//PF00130//PF08996//PF05715//PF06061//PF13465//PF02892//PF13912//PF01363//PF01844//PF16622 Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//DNA Polymerase alpha zinc finger//Piccolo Zn-finger//Baculoviridae ME53//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//FYVE zinc finger//HNH endonuclease//zinc-finger C2H2-type GO:0006260//GO:0035556 DNA replication//intracellular signal transduction GO:0008270//GO:0003676//GO:0001882//GO:0046872//GO:0004519//GO:0003677//GO:0003887 zinc ion binding//nucleic acid binding//nucleoside binding//metal ion binding//endonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0045202//GO:0042575 synapse//DNA polymerase complex -- -- Cluster-8309.11937 BP_3 18.00 2.51 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11938 BP_3 42.00 51.44 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11941 BP_3 7.00 1.08 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11942 BP_3 89.00 23.12 477 768446241 XP_011565052.1 284 3.6e-23 PREDICTED: cuticle protein CP14.6-like isoform X1 [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q94984 256 2.6e-21 Cuticle protein CP14.6 OS=Manduca sexta GN=CP14.6 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.11943 BP_3 9.00 0.42 1319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11948 BP_3 357.00 14.74 1459 478253978 ENN74270.1 532 1.9e-51 hypothetical protein YQE_09242, partial [Dendroctonus ponderosae]>gi|546674816|gb|ERL86102.1| hypothetical protein D910_03516 [Dendroctonus ponderosae] -- -- -- -- -- K13176 THOC7 THO complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13176 A7RX34 332 1.2e-29 THO complex subunit 7 homolog OS=Nematostella vectensis GN=thoc7 PE=3 SV=1 PF02305//PF08657//PF05531//PF00430//PF10473//PF05615 Capsid protein (F protein)//DASH complex subunit Spc34//Nucleopolyhedrovirus P10 protein//ATP synthase B/B' CF(0)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Tho complex subunit 7 GO:0015992//GO:0008608//GO:0015986//GO:0006397 proton transport//attachment of spindle microtubules to kinetochore//ATP synthesis coupled proton transport//mRNA processing GO:0015078//GO:0005198//GO:0008134//GO:0045502//GO:0042803 hydrogen ion transmembrane transporter activity//structural molecule activity//transcription factor binding//dynein binding//protein homodimerization activity GO:0000445//GO:0005876//GO:0042729//GO:0045263//GO:0019028//GO:0005667//GO:0030286 THO complex part of transcription export complex//spindle microtubule//DASH complex//proton-transporting ATP synthase complex, coupling factor F(o)//viral capsid//transcription factor complex//dynein complex KOG3215 Uncharacterized conserved protein Cluster-8309.1195 BP_3 1.00 5.19 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11953 BP_3 4.00 0.50 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11956 BP_3 15.00 0.86 1135 642920682 XP_008192520.1 873 4.3e-91 PREDICTED: transcriptional regulator ATRX homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06459 Ryanodine Receptor TM 4-6 GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.11957 BP_3 10.00 1.26 673 478258747 ENN78773.1 412 7.3e-38 hypothetical protein YQE_04760, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex -- -- Cluster-8309.11958 BP_3 146.75 3.51 2305 91092928 XP_971830.1 1416 9.6e-154 PREDICTED: ecto-NOX disulfide-thiol exchanger 2 [Tribolium castaneum]>gi|270003029|gb|EEZ99476.1| hypothetical protein TcasGA2_TC000049 [Tribolium castaneum] 642916932 XM_966737.2 140 1.55477e-64 PREDICTED: Tribolium castaneum ecto-NOX disulfide-thiol exchanger 2 (LOC660510), mRNA -- -- -- -- Q16206 812 4.3e-85 Ecto-NOX disulfide-thiol exchanger 2 OS=Homo sapiens GN=ENOX2 PE=1 SV=2 PF07716//PF15898//PF16367//PF00076//PF03938//PF04772//PF01576//PF07851 Basic region leucine zipper//cGMP-dependent protein kinase interacting domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Outer membrane protein (OmpH-like)//Influenza B matrix protein 2 (BM2)//Myosin tail//TMPIT-like protein GO:0015992//GO:0006355 proton transport//regulation of transcription, DNA-templated GO:0003700//GO:0097159//GO:0051082//GO:0043565//GO:0003676//GO:1901363//GO:0003774//GO:0019901 transcription factor activity, sequence-specific DNA binding//organic cyclic compound binding//unfolded protein binding//sequence-specific DNA binding//nucleic acid binding//heterocyclic compound binding//motor activity//protein kinase binding GO:0005667//GO:0016021//GO:0016459 transcription factor complex//integral component of membrane//myosin complex -- -- Cluster-8309.11963 BP_3 1.00 0.53 380 861642949 KMQ94131.1 133 9.3e-06 limulus clotting factor c [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11968 BP_3 5.00 0.71 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11972 BP_3 8.00 3.71 394 270016479 EFA12925.1 143 6.7e-07 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11976 BP_3 169.12 1.40 6121 642919894 XP_008192113.1 803 3.1e-82 PREDICTED: mucin-17 isoform X1 [Tribolium castaneum]>gi|642919896|ref|XP_008192115.1| PREDICTED: mucin-17 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11977 BP_3 94.43 1.39 3561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1198 BP_3 56.00 1.11 2715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.11981 BP_3 21.00 1.01 1297 189236235 XP_972873.2 777 6.7e-80 PREDICTED: dopamine N-acetyltransferase [Tribolium castaneum]>gi|270005795|gb|EFA02243.1| hypothetical protein TcasGA2_TC007905 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94521 201 1.7e-14 Dopamine N-acetyltransferase OS=Drosophila melanogaster GN=Dat PE=1 SV=1 PF13508//PF00583//PF01135 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0046500//GO:0042967//GO:0006464//GO:0006479 S-adenosylmethionine metabolic process//acyl-carrier-protein biosynthetic process//cellular protein modification process//protein methylation GO:0008080//GO:0004719 N-acetyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity -- -- -- -- Cluster-8309.11986 BP_3 24.00 0.76 1823 728418448 AIY68369.1 1539 4.1e-168 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q8R0W5 691 3.6e-71 Carboxylesterase 4A OS=Mus musculus GN=Ces4a PE=2 SV=2 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.11989 BP_3 27.54 1.53 1157 861599125 KMQ83546.1 230 1.6e-16 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1199 BP_3 19.00 0.43 2397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11993 BP_3 230.72 7.44 1786 189240985 XP_001808932.1 2020 6.8e-224 PREDICTED: probable cytosolic Fe-S cluster assembly factor CPIJ010948 [Tribolium castaneum]>gi|270012992|gb|EFA09440.1| hypothetical protein TcasGA2_TC010652 [Tribolium castaneum] 462325677 APGK01041744.1 51 3.57893e-15 Dendroctonus ponderosae Seq01041754, whole genome shotgun sequence -- -- -- -- Q7PWB8 1454 1.2e-159 Probable cytosolic Fe-S cluster assembly factor AGAP009023 OS=Anopheles gambiae GN=AGAP009023 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2439 Nuclear architecture related protein Cluster-8309.11997 BP_3 102.40 1.52 3533 91083375 XP_966996.1 2096 2.1e-232 PREDICTED: EGF domain-specific O-linked N-acetylglucosamine transferase [Tribolium castaneum]>gi|270006906|gb|EFA03354.1| hypothetical protein TcasGA2_TC013339 [Tribolium castaneum] 242007552 XM_002424559.1 86 2.49824e-34 Pediculus humanus corporis glycosyltransferase, putative, mRNA K18134 EOGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18134 Q9VQB7 1339 5.1e-146 EGF domain-specific O-linked N-acetylglucosamine transferase OS=Drosophila melanogaster GN=Eogt PE=1 SV=1 PF04577//PF06423 Protein of unknown function (DUF563)//GWT1 GO:0006506 GPI anchor biosynthetic process GO:0016746//GO:0016757 transferase activity, transferring acyl groups//transferase activity, transferring glycosyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0411 Uncharacterized membrane protein Cluster-8309.11998 BP_3 103.50 1.54 3532 91083375 XP_966996.1 2096 2.1e-232 PREDICTED: EGF domain-specific O-linked N-acetylglucosamine transferase [Tribolium castaneum]>gi|270006906|gb|EFA03354.1| hypothetical protein TcasGA2_TC013339 [Tribolium castaneum] 242007552 XM_002424559.1 86 2.49752e-34 Pediculus humanus corporis glycosyltransferase, putative, mRNA K18134 EOGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18134 Q9VQB7 1339 5.1e-146 EGF domain-specific O-linked N-acetylglucosamine transferase OS=Drosophila melanogaster GN=Eogt PE=1 SV=1 PF06423//PF04577 GWT1//Protein of unknown function (DUF563) GO:0006506 GPI anchor biosynthetic process GO:0016757//GO:0016746 transferase activity, transferring glycosyl groups//transferase activity, transferring acyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0411 Uncharacterized membrane protein Cluster-8309.1200 BP_3 4.00 5.95 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12000 BP_3 451.10 6.81 3483 91083375 XP_966996.1 2096 2.0e-232 PREDICTED: EGF domain-specific O-linked N-acetylglucosamine transferase [Tribolium castaneum]>gi|270006906|gb|EFA03354.1| hypothetical protein TcasGA2_TC013339 [Tribolium castaneum] 242007552 XM_002424559.1 86 2.46252e-34 Pediculus humanus corporis glycosyltransferase, putative, mRNA K18134 EOGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18134 Q9VQB7 1339 5.0e-146 EGF domain-specific O-linked N-acetylglucosamine transferase OS=Drosophila melanogaster GN=Eogt PE=1 SV=1 PF06423//PF04577 GWT1//Protein of unknown function (DUF563) GO:0006506 GPI anchor biosynthetic process GO:0016757//GO:0016746 transferase activity, transferring glycosyl groups//transferase activity, transferring acyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0411 Uncharacterized membrane protein Cluster-8309.12004 BP_3 4.00 0.32 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12007 BP_3 19.30 1.84 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12008 BP_3 247.22 3.55 3645 91083749 XP_971342.1 2229 8.1e-248 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 1104 9.4e-119 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12012 BP_3 4.00 0.96 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12016 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12022 BP_3 51.18 1.00 2769 91083991 XP_975229.1 1974 2.3e-218 PREDICTED: origin recognition complex subunit 3 [Tribolium castaneum]>gi|270006709|gb|EFA03157.1| hypothetical protein TcasGA2_TC013076 [Tribolium castaneum] -- -- -- -- -- K02605 ORC3 origin recognition complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02605 Q9UBD5 982 1.0e-104 Origin recognition complex subunit 3 OS=Homo sapiens GN=ORC3 PE=1 SV=1 PF07034//PF07531//PF04421 Origin recognition complex (ORC) subunit 3 N-terminus//NHR1 homology to TAF//Mss4 protein GO:0007264//GO:0043087//GO:0006260//GO:0006355 small GTPase mediated signal transduction//regulation of GTPase activity//DNA replication//regulation of transcription, DNA-templated GO:0003677//GO:0005085//GO:0003700 DNA binding//guanyl-nucleotide exchange factor activity//transcription factor activity, sequence-specific DNA binding GO:0005664//GO:0005667 nuclear origin of replication recognition complex//transcription factor complex KOG2538 Origin recognition complex, subunit 3 Cluster-8309.12023 BP_3 206.29 7.12 1688 478255527 ENN75744.1 1324 3.3e-143 hypothetical protein YQE_07704, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12025 BP_3 1.00 2.46 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12029 BP_3 576.17 9.58 3190 642925584 XP_008194609.1 2725 2.2e-305 PREDICTED: LOW QUALITY PROTEIN: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 498 1.5e-48 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF05434 Acyltransferase family//TMEM9 -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016021 integral component of membrane -- -- Cluster-8309.12035 BP_3 8.00 1.02 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12036 BP_3 1.02 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12037 BP_3 2.09 0.40 542 91077048 XP_968190.1 311 3.0e-26 PREDICTED: coiled-coil domain-containing protein 58 [Tribolium castaneum]>gi|270001743|gb|EEZ98190.1| hypothetical protein TcasGA2_TC000619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4FUI1 217 9.9e-17 Coiled-coil domain-containing protein 58 OS=Bos taurus GN=CCDC58 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12038 BP_3 144.89 14.54 772 91077048 XP_968190.1 498 9.0e-48 PREDICTED: coiled-coil domain-containing protein 58 [Tribolium castaneum]>gi|270001743|gb|EEZ98190.1| hypothetical protein TcasGA2_TC000619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FX56 348 9.1e-32 Coiled-coil domain-containing protein 58 OS=Taeniopygia guttata GN=CCDC58 PE=2 SV=1 PF00377 Prion/Doppel alpha-helical domain GO:0051260 protein homooligomerization -- -- GO:0016020 membrane -- -- Cluster-8309.12041 BP_3 1.82 0.50 466 859132811 AKO63319.1 493 2.0e-47 3-hydroxy-3-methylglutaryl coenzyme A reductase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 461 4.3e-45 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF00368 Hydroxymethylglutaryl-coenzyme A reductase GO:0006694//GO:0055114//GO:0015936 steroid biosynthetic process//oxidation-reduction process//coenzyme A metabolic process GO:0050662//GO:0004420 coenzyme binding//hydroxymethylglutaryl-CoA reductase (NADPH) activity -- -- KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.12042 BP_3 34.00 0.71 2586 642924692 XP_008194400.1 1044 1.5e-110 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXD9 210 3.1e-15 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF01534//PF00001//PF00002//PF02086 Frizzled/Smoothened family membrane region//7 transmembrane receptor (rhodopsin family)//7 transmembrane receptor (Secretin family)//D12 class N6 adenine-specific DNA methyltransferase GO:0006306//GO:0007166//GO:0007186//GO:0032775 DNA methylation//cell surface receptor signaling pathway//G-protein coupled receptor signaling pathway//DNA methylation on adenine GO:0009007//GO:0004930 site-specific DNA-methyltransferase (adenine-specific) activity//G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.12047 BP_3 137.35 5.63 1468 478260604 ENN80307.1 690 9.3e-70 hypothetical protein YQE_03300, partial [Dendroctonus ponderosae]>gi|546685264|gb|ERL94791.1| hypothetical protein D910_12065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8CBW7 500 4.1e-49 Cysteine-rich hydrophobic domain-containing protein 1 OS=Mus musculus GN=Chic1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4101 Cysteine-rich hydrophobic proteins Cluster-8309.1205 BP_3 217.09 13.16 1087 642922567 XP_969703.2 572 3.3e-56 PREDICTED: uncharacterized protein LOC658202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12050 BP_3 345.65 4.16 4296 646715135 KDR18839.1 1147 2.8e-122 Zinc finger MYM-type protein 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.12053 BP_3 9.35 2.63 463 642929398 XP_008195820.1 261 1.6e-20 PREDICTED: neogenin isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12056 BP_3 212.00 2.47 4429 642937210 XP_008198741.1 734 2.2e-74 PREDICTED: uncharacterized protein LOC103314438 [Tribolium castaneum]>gi|270001101|gb|EEZ97548.1| hypothetical protein TcasGA2_TC011398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12060 BP_3 125.49 2.13 3135 15450324 AAK96031.1 912 3.6e-95 homeodomain transcription factor Prothoraxless [Tribolium castaneum]>gi|270002803|gb|EEZ99250.1| antennapedia [Tribolium castaneum] 86515363 NM_001039416.1 265 6.91207e-134 Tribolium castaneum prothoraxless (Ptl), mRNA >gnl|BL_ORD_ID|908858 Tribolium castaneum prothoraxless mRNA, complete cds K09307 HOX_7 homeobox protein HoxA/B7 http://www.genome.jp/dbget-bin/www_bget?ko:K09307 P02833 379 9.5e-35 Homeotic protein antennapedia OS=Drosophila melanogaster GN=Antp PE=1 SV=1 PF00046//PF03153 Homeobox domain//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.12061 BP_3 4.00 1.25 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12064 BP_3 77.00 5.46 971 34616 CAA23830.1 558 1.2e-54 beta-2 microglobulin [Homo sapiens] 37704380 NM_004048.2 941 0 Homo sapiens beta-2-microglobulin (B2M), mRNA K08055 B2M beta-2-microglobulin http://www.genome.jp/dbget-bin/www_bget?ko:K08055 P61770 559 3.9e-56 Beta-2-microglobulin OS=Pan troglodytes GN=B2M PE=3 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12067 BP_3 1.00 1.58 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12068 BP_3 4.00 0.47 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12070 BP_3 106.24 2.80 2122 332372486 AEE61385.1 1557 3.9e-170 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5LJP9 882 3.0e-93 Asparagine synthetase domain-containing protein CG17486 OS=Drosophila melanogaster GN=CG17486 PE=2 SV=2 PF00733 Asparagine synthase GO:0006531//GO:0006522//GO:0006529 aspartate metabolic process//alanine metabolic process//asparagine biosynthetic process GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0573 Asparagine synthase Cluster-8309.12071 BP_3 1.00 0.40 411 780616929 XP_011698547.1 155 2.8e-08 PREDICTED: zinc finger BED domain-containing protein RICESLEEPER 2-like [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.12072 BP_3 35.74 0.56 3393 91087671 XP_976426.1 327 2.7e-27 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12074 BP_3 4.61 0.31 1019 91093429 XP_968933.1 192 3.6e-12 PREDICTED: uncharacterized protein LOC657376 [Tribolium castaneum]>gi|270015461|gb|EFA11909.1| hypothetical protein TcasGA2_TC004066 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04210//PF05525 Tetrahydromethanopterin S-methyltransferase, subunit G//Branched-chain amino acid transport protein GO:0015948//GO:0015803//GO:0046656 methanogenesis//branched-chain amino acid transport//folic acid biosynthetic process GO:0015658//GO:0030269 branched-chain amino acid transmembrane transporter activity//tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.12078 BP_3 13.64 0.48 1668 91077474 XP_968267.1 2211 4.5e-246 PREDICTED: pleiotropic regulator 1 [Tribolium castaneum]>gi|642914017|ref|XP_008201512.1| PREDICTED: pleiotropic regulator 1 [Tribolium castaneum]>gi|270002139|gb|EEZ98586.1| hypothetical protein TcasGA2_TC001100 [Tribolium castaneum] -- -- -- -- -- K12862 PLRG1, PRL1, PRP46 pleiotropic regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12862 Q2KID6 1488 1.3e-163 Pleiotropic regulator 1 OS=Bos taurus GN=PLRG1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0285 Pleiotropic regulator 1 Cluster-8309.12079 BP_3 2.00 0.41 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12082 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12083 BP_3 9.00 0.63 975 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12085 BP_3 1196.66 37.35 1836 642929081 XP_008195683.1 972 2.3e-102 PREDICTED: venom metalloproteinase 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01562 Reprolysin family propeptide GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.12087 BP_3 861.83 21.61 2214 270015076 EFA11524.1 469 5.9e-44 hypothetical protein TcasGA2_TC014239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.12088 BP_3 7.64 1.07 635 642935095 XP_008197883.1 165 3.0e-09 PREDICTED: uncharacterized protein LOC103314233 [Tribolium castaneum]>gi|270013398|gb|EFA09846.1| hypothetical protein TcasGA2_TC011994 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1209 BP_3 5.00 1.28 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04517 Microvirus lysis protein (E), C terminus GO:0019054 modulation by virus of host process GO:0004857 enzyme inhibitor activity -- -- -- -- Cluster-8309.12092 BP_3 40.00 0.88 2477 642934637 XP_008197748.1 1341 5.1e-145 PREDICTED: uncharacterized protein LOC103314202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08072 BDHCT (NUC031) domain GO:0006260 DNA replication GO:0003677//GO:0005524//GO:0016818 DNA binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus -- -- Cluster-8309.12093 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12095 BP_3 3.00 0.81 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12096 BP_3 49.00 30.07 367 195376219 XP_002046894.1 265 4.4e-21 GJ13137 [Drosophila virilis]>gi|194154052|gb|EDW69236.1| GJ13137 [Drosophila virilis] -- -- -- -- -- -- -- -- -- Q7M4F3 215 1.1e-16 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12097 BP_3 9.00 3.04 434 642930000 XP_008196060.1 276 2.8e-22 PREDICTED: calphotin [Tribolium castaneum] 642929999 XM_008197838.1 106 2.18551e-46 PREDICTED: Tribolium castaneum calphotin (LOC664580), mRNA -- -- -- -- P11733 241 1.3e-19 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12099 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08491 Squalene epoxidase GO:0055114//GO:0006694//GO:0016114 oxidation-reduction process//steroid biosynthetic process//terpenoid biosynthetic process GO:0004506//GO:0050660 squalene monooxygenase activity//flavin adenine dinucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.121 BP_3 45.03 0.81 2967 270004458 EFA00906.1 1189 2.6e-127 hypothetical protein TcasGA2_TC003812 [Tribolium castaneum] -- -- -- -- -- K10395 KIF4_21_27 kinesin family member 4/21/27 http://www.genome.jp/dbget-bin/www_bget?ko:K10395 P33174 601 1.6e-60 Chromosome-associated kinesin KIF4 OS=Mus musculus GN=Kif4 PE=1 SV=3 PF00633//PF00225 Helix-hairpin-helix motif//Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0003777//GO:0003677//GO:0005524//GO:0008017 microtubule motor activity//DNA binding//ATP binding//microtubule binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG0243 Kinesin-like protein Cluster-8309.12107 BP_3 27.84 0.43 3397 546681078 ERL91234.1 911 5.1e-95 hypothetical protein D910_08570 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O43903 261 4.9e-21 Growth arrest-specific protein 2 OS=Homo sapiens GN=GAS2 PE=1 SV=1 PF02187//PF00307 Growth-Arrest-Specific Protein 2 Domain//Calponin homology (CH) domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.12108 BP_3 199.15 2.55 4055 546681078 ERL91234.1 1219 1.2e-130 hypothetical protein D910_08570 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O43903 261 5.9e-21 Growth arrest-specific protein 2 OS=Homo sapiens GN=GAS2 PE=1 SV=1 PF00307//PF02187 Calponin homology (CH) domain//Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.1211 BP_3 6.00 0.57 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12111 BP_3 40.65 0.74 2926 642918266 XP_008191438.1 2465 2.8e-275 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 2156 7.8e-241 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 PF13202//PF12763//PF13833//PF10591//PF13405//PF00036//PF13499 EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF-hand domain pair GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.12114 BP_3 5.00 0.45 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12123 BP_3 5.00 1.41 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12124 BP_3 15.00 1.27 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12128 BP_3 50.00 5.29 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1213 BP_3 21.00 0.40 2815 270017178 EFA13624.1 257 2.9e-19 hypothetical protein TcasGA2_TC005269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12130 BP_3 40.00 0.80 2694 857971097 CEP02564.1 579 1.3e-56 hypothetical protein PBRA_009148 [Plasmodiophora brassicae] -- -- -- -- -- -- -- -- -- Q8TF66 347 4.2e-31 Leucine-rich repeat-containing protein 15 OS=Homo sapiens GN=LRRC15 PE=2 SV=2 PF13855//PF00560//PF13413 Leucine rich repeat//Leucine Rich Repeat//Helix-turn-helix domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.12131 BP_3 36.03 0.82 2414 270004760 EFA01208.1 211 5.4e-14 hypothetical protein TcasGA2_TC010535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12133 BP_3 14.00 1.02 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12134 BP_3 89.00 4.01 1361 78214230 ABB36437.1 161 1.9e-08 RE54418p [Drosophila melanogaster] -- -- -- -- -- K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 161 7.8e-10 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1495 Lactate dehydrogenase Cluster-8309.12135 BP_3 9.00 2.90 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01665 Rotavirus non-structural protein NSP3 -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.12136 BP_3 5.00 0.55 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1214 BP_3 125.21 5.13 1469 642931180 XP_008196472.1 1269 6.8e-137 PREDICTED: pachytene checkpoint protein 2 homolog [Tribolium castaneum]>gi|270012108|gb|EFA08556.1| hypothetical protein TcasGA2_TC006211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P4W8 947 6.1e-101 Pachytene checkpoint protein 2 homolog OS=Xenopus tropicalis GN=trip13 PE=2 SV=1 PF00158//PF07728//PF01695//PF00004//PF02367//PF02562//PF00931//PF06068//PF05496//PF01443//PF00448//PF07724//PF02224//PF00437//PF04851//PF01637//PF07726//PF00005//PF10662//PF00910 Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//NB-ARC domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//SRP54-type protein, GTPase domain//AAA domain (Cdc48 subfamily)//Cytidylate kinase//Type II/IV secretion system protein//Type III restriction enzyme, res subunit//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//ABC transporter//Ethanolamine utilisation - propanediol utilisation//RNA helicase GO:0002949//GO:0006310//GO:0006206//GO:0006576//GO:0006355//GO:0006139//GO:0006810//GO:0006281//GO:0006614 tRNA threonylcarbamoyladenosine modification//DNA recombination//pyrimidine nucleobase metabolic process//cellular biogenic amine metabolic process//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process//transport//DNA repair//SRP-dependent cotranslational protein targeting to membrane GO:0009378//GO:0003724//GO:0005525//GO:0043531//GO:0003678//GO:0003723//GO:0003677//GO:0000166//GO:0004127//GO:0016887//GO:0008134//GO:0005524//GO:0016787 four-way junction helicase activity//RNA helicase activity//GTP binding//ADP binding//DNA helicase activity//RNA binding//DNA binding//nucleotide binding//cytidylate kinase activity//ATPase activity//transcription factor binding//ATP binding//hydrolase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0744 AAA+-type ATPase Cluster-8309.12140 BP_3 139.00 18.91 646 270015669 EFA12117.1 748 7.7e-77 hypothetical protein TcasGA2_TC002263 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03067 Chitin binding domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.12141 BP_3 588.11 19.16 1771 546684870 ERL94452.1 439 1.4e-40 hypothetical protein D910_11729 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045//PF09398 LisH//FOP N terminal dimerisation domain GO:0034453 microtubule anchoring GO:0005515 protein binding GO:0005815 microtubule organizing center -- -- Cluster-8309.12146 BP_3 21.15 0.47 2463 91083991 XP_975229.1 1810 2.1e-199 PREDICTED: origin recognition complex subunit 3 [Tribolium castaneum]>gi|270006709|gb|EFA03157.1| hypothetical protein TcasGA2_TC013076 [Tribolium castaneum] -- -- -- -- -- K02605 ORC3 origin recognition complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02605 Q32PJ3 859 1.6e-90 Origin recognition complex subunit 3 OS=Bos taurus GN=ORC3 PE=2 SV=1 PF07531//PF07034//PF04421 NHR1 homology to TAF//Origin recognition complex (ORC) subunit 3 N-terminus//Mss4 protein GO:0006355//GO:0043087//GO:0006260//GO:0007264 regulation of transcription, DNA-templated//regulation of GTPase activity//DNA replication//small GTPase mediated signal transduction GO:0005085//GO:0003677//GO:0003700 guanyl-nucleotide exchange factor activity//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005664 transcription factor complex//nuclear origin of replication recognition complex KOG2538 Origin recognition complex, subunit 3 Cluster-8309.12149 BP_3 23.60 1.69 965 478257001 ENN77165.1 586 7.0e-58 hypothetical protein YQE_06304, partial [Dendroctonus ponderosae]>gi|546675571|gb|ERL86740.1| hypothetical protein D910_04146 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3UJZ3 330 1.4e-29 Armadillo repeat-containing protein 7 OS=Mus musculus GN=Armc7 PE=2 SV=2 PF00514//PF01245//PF01157 Armadillo/beta-catenin-like repeat//Ribosomal protein L19//Ribosomal protein L21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840//GO:0005622 ribosome//intracellular KOG4646 Uncharacterized conserved protein, contains ARM repeats Cluster-8309.1215 BP_3 3.27 0.76 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12150 BP_3 247.84 48.68 537 642923944 XP_008193936.1 262 1.4e-20 PREDICTED: flexible cuticle protein 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45589 194 4.6e-14 Flexible cuticle protein 12 OS=Hyalophora cecropia GN=CP12 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12152 BP_3 5.44 0.35 1034 91080431 XP_968599.1 159 2.5e-08 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12154 BP_3 21.00 0.46 2471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12161 BP_3 10.19 0.77 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15199 D-amino acid oxidase activator GO:1900758 negative regulation of D-amino-acid oxidase activity -- -- -- -- -- -- Cluster-8309.12162 BP_3 156.00 2.29 3582 478254748 ENN74985.1 1310 2.9e-141 hypothetical protein YQE_08442, partial [Dendroctonus ponderosae] 198455838 XM_001360087.2 43 2.02883e-10 Drosophila pseudoobscura pseudoobscura GA17177 (Dpse\GA17177), partial mRNA K04577 CALCRL calcitonin receptor-like http://www.genome.jp/dbget-bin/www_bget?ko:K04577 Q8AXU4 529 4.4e-52 Calcitonin gene-related peptide type 1 receptor OS=Oncorhynchus gorbuscha GN=calcrl PE=2 SV=1 PF00002//PF02793//PF09384 7 transmembrane receptor (Secretin family)//Hormone receptor domain//UTP15 C terminal GO:0007186//GO:0006364 G-protein coupled receptor signaling pathway//rRNA processing GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0016020//GO:0005730 integral component of membrane//membrane//nucleolus -- -- Cluster-8309.12163 BP_3 12.00 0.64 1198 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12164 BP_3 7.00 0.66 806 91076320 XP_970028.1 395 8.2e-36 PREDICTED: endocuticle structural glycoprotein SgAbd-2 [Tribolium castaneum]>gi|270002481|gb|EEZ98928.1| hypothetical protein TcasGA2_TC004548 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 295 1.3e-25 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12169 BP_3 3.00 0.39 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12170 BP_3 3716.00 62.23 3170 478263313 ENN81692.1 568 2.8e-55 hypothetical protein YQE_01898, partial [Dendroctonus ponderosae]>gi|546681338|gb|ERL91452.1| hypothetical protein D910_08782 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12173 BP_3 5.00 1.15 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12180 BP_3 22.00 15.06 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04162//PF05373 Gyrovirus capsid protein (VP1)//L-proline 3-hydroxylase, C-terminal GO:0055114 oxidation-reduction process GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0019028 viral capsid -- -- Cluster-8309.12183 BP_3 199.00 11.27 1143 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12184 BP_3 52.00 2.95 1142 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12187 BP_3 5576.58 79.00 3694 546681742 ERL91774.1 4465 0.0e+00 hypothetical protein D910_09100 [Dendroctonus ponderosae] 815770796 XM_012380129.1 60 7.42168e-20 PREDICTED: Linepithema humile uncharacterized LOC105679844 (LOC105679844), transcript variant X3, mRNA -- -- -- -- Q5ACV9 167 4.3e-10 Cell surface superoxide dismutase [Cu-Zn] 6 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SOD6 PE=1 SV=1 PF01194//PF00080 RNA polymerases N / 8 kDa subunit//Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006206//GO:0006801//GO:0006144//GO:0006351 oxidation-reduction process//pyrimidine nucleobase metabolic process//superoxide metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.12190 BP_3 25.00 0.86 1700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12195 BP_3 17.00 0.84 1267 546677394 ERL88240.1 298 2.3e-24 hypothetical protein D910_05628, partial [Dendroctonus ponderosae] -- -- -- -- -- K19363 LITAF lipopolysaccharide-induced tumor necrosis factor-alpha factor http://www.genome.jp/dbget-bin/www_bget?ko:K19363 Q8QGW7 153 6.1e-09 Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog OS=Gallus gallus GN=LITAF PE=2 SV=1 PF03811 InsA N-terminal domain GO:0006313 transposition, DNA-mediated -- -- -- -- -- -- Cluster-8309.122 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12200 BP_3 1466.00 37.24 2189 270009891 EFA06339.1 1443 6.7e-157 hypothetical protein TcasGA2_TC009212 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q06852 201 2.9e-14 Cell surface glycoprotein 1 OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) GN=olpB PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12202 BP_3 10.00 0.68 1004 -- -- -- -- -- 359294281 JN986793.1 79 5.39835e-31 Batocera lineolata mitochondrion, complete genome -- -- -- -- -- -- -- -- PF13939 Toxin TisB, type I toxin-antitoxin system GO:0006820//GO:0022611//GO:0009432 anion transport//dormancy process//SOS response GO:0005253 anion channel activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.12208 BP_3 14.00 0.50 1635 594064207 XP_006056122.1 1626 3.0e-178 PREDICTED: L-lactate dehydrogenase A chain isoform X1 [Bubalus bubalis] 92446377 BC072009.1 1635 0 Homo sapiens lactate dehydrogenase A, mRNA (cDNA clone IMAGE:4551914), **** WARNING: chimeric clone **** K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 P19858 1553 3.6e-171 L-lactate dehydrogenase A chain OS=Bos taurus GN=LDHA PE=2 SV=2 PF02056//PF11975//PF00056//PF07992//PF02866 Family 4 glycosyl hydrolase//Family 4 glycosyl hydrolase C-terminal domain//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114//GO:0005975 oxidation-reduction process//carbohydrate metabolic process GO:0016616//GO:0016491//GO:0004553 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1495 Lactate dehydrogenase Cluster-8309.12212 BP_3 55.40 4.10 943 642918102 XP_008194021.1 600 1.6e-59 PREDICTED: Krueppel-like factor 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09206 KLF5 krueppel-like factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09206 Q13887 198 2.8e-14 Krueppel-like factor 5 OS=Homo sapiens GN=KLF5 PE=1 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.12214 BP_3 24.65 0.52 2557 642935038 XP_008199916.1 150 6.7e-07 PREDICTED: complexin isoform X2 [Tribolium castaneum] 642935035 XM_008201693.1 198 9.89379e-97 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF10186//PF03938//PF04111//PF05835//PF02841 Vacuolar sorting 38 and autophagy-related subunit 14//Outer membrane protein (OmpH-like)//Autophagy protein Apg6//Synaphin protein//Guanylate-binding protein, C-terminal domain GO:0010508//GO:0006914//GO:0006836 positive regulation of autophagy//autophagy//neurotransmitter transport GO:0019905//GO:0003924//GO:0051082//GO:0005525 syntaxin binding//GTPase activity//unfolded protein binding//GTP binding -- -- -- -- Cluster-8309.12218 BP_3 103.47 1.71 3201 642929350 XP_008195799.1 2124 1.1e-235 PREDICTED: translation initiation factor IF-2, mitochondrial [Tribolium castaneum] 769830568 XM_011632673.1 65 1.06696e-22 PREDICTED: Pogonomyrmex barbatus translation initiation factor IF-2, mitochondrial (LOC105423025), transcript variant X4, mRNA K02519 infB, MTIF2 translation initiation factor IF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K02519 P46198 1350 2.5e-147 Translation initiation factor IF-2, mitochondrial OS=Bos taurus GN=MTIF2 PE=1 SV=1 PF01926//PF03144//PF03193//PF08477//PF02421//PF00025//PF10662 50S ribosome-binding GTPase//Elongation factor Tu domain 2//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation GO:0015684//GO:0007264//GO:0006576 ferrous iron transport//small GTPase mediated signal transduction//cellular biogenic amine metabolic process GO:0005525//GO:0003924//GO:0015093//GO:0005524 GTP binding//GTPase activity//ferrous iron transmembrane transporter activity//ATP binding GO:0016021 integral component of membrane KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase) Cluster-8309.12219 BP_3 60.96 1.43 2345 642929350 XP_008195799.1 1388 1.7e-150 PREDICTED: translation initiation factor IF-2, mitochondrial [Tribolium castaneum] 769830568 XM_011632673.1 65 7.78972e-23 PREDICTED: Pogonomyrmex barbatus translation initiation factor IF-2, mitochondrial (LOC105423025), transcript variant X4, mRNA K02519 infB, MTIF2 translation initiation factor IF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K02519 P46198 839 3.2e-88 Translation initiation factor IF-2, mitochondrial OS=Bos taurus GN=MTIF2 PE=1 SV=1 PF10662//PF02421//PF00025//PF01926//PF03193//PF08477 Ethanolamine utilisation - propanediol utilisation//Ferrous iron transport protein B//ADP-ribosylation factor family//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0006576//GO:0015684//GO:0007264 cellular biogenic amine metabolic process//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0015093//GO:0005524//GO:0005525 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding GO:0016021 integral component of membrane KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase) Cluster-8309.12220 BP_3 30.40 0.62 2644 478258000 ENN78138.1 1038 7.4e-110 hypothetical protein YQE_05292, partial [Dendroctonus ponderosae] -- -- -- -- -- K02519 infB, MTIF2 translation initiation factor IF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K02519 P46199 675 3.8e-69 Translation initiation factor IF-2, mitochondrial OS=Homo sapiens GN=MTIF2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase) Cluster-8309.12223 BP_3 32.97 0.68 2631 478259695 ENN79539.1 904 2.6e-94 hypothetical protein YQE_04002, partial [Dendroctonus ponderosae]>gi|546679825|gb|ERL90217.1| hypothetical protein D910_07570 [Dendroctonus ponderosae] -- -- -- -- -- K05995 pepE dipeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K05995 Q91642 697 1.1e-71 Alpha-aspartyl dipeptidase OS=Xenopus laevis GN=aad-a PE=1 SV=1 PF03575 Peptidase family S51 GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- -- -- Cluster-8309.12233 BP_3 10414.64 217.47 2600 546677436 ERL88273.1 874 7.6e-91 hypothetical protein D910_05660 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.12236 BP_3 2.00 0.38 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12239 BP_3 17.43 0.62 1654 642929647 XP_008195919.1 170 2.1e-09 PREDICTED: uncharacterized protein LOC664363 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12243 BP_3 103.55 15.83 607 189239365 XP_970191.2 251 3.1e-19 PREDICTED: probable chitinase 2 [Tribolium castaneum]>gi|270010475|gb|EFA06923.1| hypothetical protein TcasGA2_TC009872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.1225 BP_3 1.00 0.33 438 478253894 ENN74186.1 304 1.6e-25 hypothetical protein YQE_09159, partial [Dendroctonus ponderosae]>gi|546674899|gb|ERL86185.1| hypothetical protein D910_03598 [Dendroctonus ponderosae]>gi|546684704|gb|ERL94321.1| hypothetical protein D910_11602 [Dendroctonus ponderosae]>gi|546686839|gb|ERL95870.1| hypothetical protein D910_00503 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12253 BP_3 6.00 1.09 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12254 BP_3 7.80 0.43 1158 270004689 EFA01137.1 221 1.8e-15 hypothetical protein TcasGA2_TC010361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.12256 BP_3 18.00 0.81 1367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12261 BP_3 4.00 4.48 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12268 BP_3 215.36 3.82 3006 642927554 XP_008195313.1 3133 0.0e+00 PREDICTED: UPF0505 protein C16orf62 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z3J2 2101 1.9e-234 UPF0505 protein C16orf62 OS=Homo sapiens GN=C16orf62 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3682 Predicted membrane protein (associated with esophageal cancer in humans) Cluster-8309.12269 BP_3 120.00 2.02 3150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12270 BP_3 91.00 3.98 1394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12272 BP_3 2283.00 51.17 2442 546686651 ERL95783.1 2003 8.7e-222 hypothetical protein D910_00297, partial [Dendroctonus ponderosae]>gi|546687005|gb|ERL95945.1| hypothetical protein D910_00649, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P18173 1023 1.6e-109 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF07992//PF05834//PF00732//PF02558//PF02254//PF05199 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Ketopantoate reductase PanE/ApbA//TrkA-N domain//GMC oxidoreductase GO:0006813//GO:0015940//GO:0055114//GO:0016117 potassium ion transport//pantothenate biosynthetic process//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0016705//GO:0016614//GO:0050660//GO:0008677 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity -- -- -- -- Cluster-8309.12273 BP_3 237.00 31.62 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12278 BP_3 2.00 0.67 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1228 BP_3 88.32 1.78 2688 270004458 EFA00906.1 1079 1.3e-114 hypothetical protein TcasGA2_TC003812 [Tribolium castaneum] -- -- -- -- -- K10395 KIF4_21_27 kinesin family member 4/21/27 http://www.genome.jp/dbget-bin/www_bget?ko:K10395 P33174 561 6.4e-56 Chromosome-associated kinesin KIF4 OS=Mus musculus GN=Kif4 PE=1 SV=3 PF00633//PF00225 Helix-hairpin-helix motif//Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0003777//GO:0005524//GO:0003677 microtubule binding//microtubule motor activity//ATP binding//DNA binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG0243 Kinesin-like protein Cluster-8309.12280 BP_3 17.96 0.74 1461 91078614 XP_967493.1 1057 2.6e-112 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 37 1.76662e-07 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 O43752 526 4.0e-52 Syntaxin-6 OS=Homo sapiens GN=STX6 PE=1 SV=1 PF05739//PF00957//PF00523//PF05478 SNARE domain//Synaptobrevin//Fusion glycoprotein F0//Prominin GO:0006948//GO:0016192 induction by virus of host cell-cell fusion//vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.12281 BP_3 14.00 1.97 634 642938165 XP_008190990.1 212 1.1e-14 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.12283 BP_3 31.00 4.98 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12285 BP_3 176.44 1.15 7714 642912091 XP_008200799.1 812 3.5e-83 PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912093|ref|XP_008200800.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912095|ref|XP_008200802.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02207 Putative zinc finger in N-recognin (UBR box) -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.12287 BP_3 183.80 1.48 6295 546674055 ERL85543.1 387 5.5e-34 hypothetical protein D910_02962 [Dendroctonus ponderosae] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 251 1.3e-19 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF08395 alpha/beta hydrolase fold//7tm Chemosensory receptor GO:0050909//GO:0008152 sensory perception of taste//metabolic process GO:0016787 hydrolase activity GO:0016021 integral component of membrane KOG1516 Carboxylesterase and related proteins Cluster-8309.12288 BP_3 3.00 0.31 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12296 BP_3 432.46 17.59 1477 91081129 XP_975539.1 621 9.4e-62 PREDICTED: GILT-like protein F37H8.5 [Tribolium castaneum]>gi|270005287|gb|EFA01735.1| hypothetical protein TcasGA2_TC007331 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O17861 219 1.6e-16 GILT-like protein F37H8.5 OS=Caenorhabditis elegans GN=F37H8.5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.12298 BP_3 17.38 1.15 1020 512885690 XP_002943975.2 150 2.7e-07 PREDICTED: ephrin type-A receptor 8, partial [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- P54753 142 9.3e-08 Ephrin type-B receptor 3 OS=Homo sapiens GN=EPHB3 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.12301 BP_3 2952.04 27.32 5499 91086865 XP_969198.1 3078 0.0e+00 PREDICTED: probable serine/threonine-protein kinase nek3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 167 6.3e-10 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.12308 BP_3 196.65 388.21 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12309 BP_3 1.00 0.38 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12311 BP_3 889.26 184.43 524 478254316 ENN74570.1 404 4.8e-37 hypothetical protein YQE_08892, partial [Dendroctonus ponderosae]>gi|546674045|gb|ERL85533.1| hypothetical protein D910_02952 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12314 BP_3 1.00 29.81 217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12315 BP_3 7.12 38.16 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q551A3 120 8.4e-06 Protein DDB_G0276689 OS=Dictyostelium discoideum GN=DDB_G0276689 PE=4 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12321 BP_3 3.00 1.28 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12324 BP_3 6906.49 48.08 7215 642925568 XP_008194603.1 2691 4.3e-301 PREDICTED: chorion peroxidase-like isoform X2 [Tribolium castaneum] 817214764 XM_012428160.1 98 1.09406e-40 PREDICTED: Orussus abietinus uncharacterized LOC105701425 (LOC105701425), mRNA -- -- -- -- Q9VEG6 1020 1.0e-108 Chorion peroxidase OS=Drosophila melanogaster GN=Pxt PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.12328 BP_3 16.12 0.57 1657 270004805 EFA01253.1 1863 1.0e-205 hypothetical protein TcasGA2_TC002449 [Tribolium castaneum] -- -- -- -- -- K04984 TRPA1, ANKTM1 transient receptor potential cation channel subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04984 Q7Z020 1420 9.7e-156 Transient receptor potential cation channel subfamily A member 1 OS=Drosophila melanogaster GN=TrpA1 PE=2 SV=4 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.12335 BP_3 484.00 18.24 1571 478257435 ENN77591.1 577 1.3e-56 hypothetical protein YQE_05886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q75UQ2 317 7.3e-28 Craniofacial development protein 1 OS=Rattus norvegicus GN=Cfdp1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4776 Uncharacterized conserved protein BCNT Cluster-8309.12336 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12337 BP_3 184.32 5.68 1857 270011728 EFA08176.1 443 5.2e-41 hypothetical protein TcasGA2_TC005803 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26627 182 3.9e-12 Sperm receptor for egg jelly OS=Strongylocentrotus purpuratus GN=REJ PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12338 BP_3 54.69 0.90 3222 270011730 EFA08178.1 522 6.2e-50 hypothetical protein TcasGA2_TC005805 [Tribolium castaneum] -- -- -- -- -- K04989 PKD1L3 polycystin 1L3 http://www.genome.jp/dbget-bin/www_bget?ko:K04989 Q7TN88 231 1.4e-17 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF01477//PF00864 PLAT/LH2 domain//ATP P2X receptor GO:0006812//GO:0033198//GO:0098655//GO:0007165 cation transport//response to ATP//cation transmembrane transport//signal transduction GO:0001614//GO:0004931//GO:0005515 purinergic nucleotide receptor activity//extracellular ATP-gated cation channel activity//protein binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.12339 BP_3 125.80 2.11 3167 270011730 EFA08178.1 830 1.2e-85 hypothetical protein TcasGA2_TC005805 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TN88 281 2.2e-23 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF01477 PLAT/LH2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12341 BP_3 63.27 1.01 3310 270011730 EFA08178.1 830 1.2e-85 hypothetical protein TcasGA2_TC005805 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TN88 281 2.3e-23 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF01477 PLAT/LH2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12344 BP_3 10.00 1.62 589 270015841 EFA12289.1 351 7.6e-31 hypothetical protein TcasGA2_TC016241 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12345 BP_3 41.00 1.50 1611 334883358 BAK38643.1 453 3.1e-42 unnamed protein product [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.12346 BP_3 30.81 0.48 3385 270015496 EFA11944.1 1307 6.1e-141 hypothetical protein TcasGA2_TC001902 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P16425 542 1.3e-53 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF00769//PF02183//PF09726//PF04977//PF16326//PF02972 Ezrin/radixin/moesin family//Homeobox associated leucine zipper//Transmembrane protein//Septum formation initiator//ABC transporter C-terminal domain//Phycoerythrin, alpha/beta chain GO:0007049//GO:0006355 cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677//GO:0008092 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding//cytoskeletal protein binding GO:0005737//GO:0030089//GO:0005667//GO:0019898//GO:0016021 cytoplasm//phycobilisome//transcription factor complex//extrinsic component of membrane//integral component of membrane -- -- Cluster-8309.12349 BP_3 24.81 1.56 1057 91078176 XP_967241.1 386 1.2e-34 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q01603 308 5.4e-27 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- GO:0006979//GO:0055114//GO:0006804 response to oxidative stress//oxidation-reduction process//obsolete peroxidase reaction GO:0004601//GO:0020037 peroxidase activity//heme binding -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.12353 BP_3 167.00 18.88 718 195478504 XP_002100541.1 207 4.6e-14 GE17120 [Drosophila yakuba]>gi|194188065|gb|EDX01649.1| GE17120 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- P80685 154 2.7e-09 Pupal cuticle protein G1A OS=Tenebrio molitor PE=1 SV=1 PF08655 DASH complex subunit Ask1 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.12354 BP_3 90.73 2.21 2271 380013584 XP_003690832.1 860 2.8e-89 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Apis florea] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 Q8AXB3 505 1.7e-49 Vascular endothelial growth factor receptor kdr-like OS=Danio rerio GN=kdrl PE=1 SV=1 PF13895//PF00069//PF05790//PF07714 Immunoglobulin domain//Protein kinase domain//Immunoglobulin C2-set domain//Protein tyrosine kinase GO:0007155//GO:0006468 cell adhesion//protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding GO:0016021 integral component of membrane KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.12355 BP_3 2.00 1.32 361 270014998 EFA11446.1 335 3.3e-29 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6Z351 134 2.8e-07 Putative aldehyde oxidase-like protein OS=Oryza sativa subsp. japonica GN=Os07g0281700 PE=3 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.1236 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12360 BP_3 121.04 1.74 3639 642932799 XP_008196988.1 3710 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X2 [Tribolium castaneum]>gi|270012453|gb|EFA08901.1| hypothetical protein TcasGA2_TC006604 [Tribolium castaneum] 642932798 XM_008198766.1 89 5.53237e-36 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1806 3.7e-200 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF00637//PF13639//PF17122//PF00097//PF17123//PF14634 Region in Clathrin and VPS//Ring finger domain//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//zinc-RING finger domain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005622 intracellular KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.12362 BP_3 13795.00 1033.65 935 478254273 ENN74527.1 148 4.2e-07 hypothetical protein YQE_08851, partial [Dendroctonus ponderosae]>gi|546671467|gb|ERL83769.1| hypothetical protein D910_00997 [Dendroctonus ponderosae]>gi|546672146|gb|ERL84147.1| hypothetical protein D910_01508 [Dendroctonus ponderosae]>gi|546674915|gb|ERL86197.1| hypothetical protein D910_03608 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04108//PF10174//PF08074//PF03153//PF10473//PF02970 Autophagy protein Apg17//RIM-binding protein of the cytomatrix active zone//CHDCT2 (NUC038) domain//Transcription factor IIA, alpha/beta subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Tubulin binding cofactor A GO:0006367//GO:0006914//GO:0007021//GO:0006355 transcription initiation from RNA polymerase II promoter//autophagy//tubulin complex assembly//regulation of transcription, DNA-templated GO:0003677//GO:0015631//GO:0042803//GO:0005524//GO:0045502//GO:0008134//GO:0008270//GO:0051082//GO:0016818 DNA binding//tubulin binding//protein homodimerization activity//ATP binding//dynein binding//transcription factor binding//zinc ion binding//unfolded protein binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634//GO:0030286//GO:0005667//GO:0005672//GO:0045298//GO:0048786 nucleus//dynein complex//transcription factor complex//transcription factor TFIIA complex//tubulin complex//presynaptic active zone -- -- Cluster-8309.12365 BP_3 921.00 15.13 3225 91081765 XP_973226.1 2303 1.9e-256 PREDICTED: leucine-rich repeat-containing protein 4 [Tribolium castaneum]>gi|270006351|gb|EFA02799.1| kekkon-1 [Tribolium castaneum] 642921386 XM_968133.2 47 1.09037e-12 PREDICTED: Tribolium castaneum kekkon-1 (LOC662007), mRNA -- -- -- -- Q3UQ28 320 6.7e-28 Peroxidasin homolog OS=Mus musculus GN=Pxdn PE=2 SV=2 PF13895//PF13855//PF00560 Immunoglobulin domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12371 BP_3 322.12 7.62 2329 642927688 XP_008196543.1 1060 1.8e-112 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 1.1e-27 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF00128//PF13855 Alpha amylase, catalytic domain//Leucine rich repeat GO:0005975 carbohydrate metabolic process GO:0043169//GO:0003824//GO:0005515 cation binding//catalytic activity//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.12372 BP_3 12.00 0.88 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12373 BP_3 17373.87 793.55 1347 166947671 ABZ04122.1 460 4.0e-43 putative cuticle protein CP5 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F3 325 7.4e-29 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF05529//PF00379 B-cell receptor-associated protein 31-like//Insect cuticle protein GO:0006886 intracellular protein transport GO:0042302 structural constituent of cuticle GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.12378 BP_3 22096.62 1679.18 926 478254273 ENN74527.1 147 5.4e-07 hypothetical protein YQE_08851, partial [Dendroctonus ponderosae]>gi|546671467|gb|ERL83769.1| hypothetical protein D910_00997 [Dendroctonus ponderosae]>gi|546672146|gb|ERL84147.1| hypothetical protein D910_01508 [Dendroctonus ponderosae]>gi|546674915|gb|ERL86197.1| hypothetical protein D910_03608 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10174//PF02970//PF04815//PF04048 RIM-binding protein of the cytomatrix active zone//Tubulin binding cofactor A//Sec23/Sec24 helical domain//Sec8 exocyst complex component specific domain GO:0007021//GO:0015031//GO:0006886//GO:0006888//GO:0006904 tubulin complex assembly//protein transport//intracellular protein transport//ER to Golgi vesicle-mediated transport//vesicle docking involved in exocytosis GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0000145//GO:0048786//GO:0030127//GO:0045298 exocyst//presynaptic active zone//COPII vesicle coat//tubulin complex -- -- Cluster-8309.12379 BP_3 83.17 0.68 6148 270009789 EFA06237.1 1463 9.1e-159 hypothetical protein TcasGA2_TC009087 [Tribolium castaneum] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 G5E8K5 232 2.1e-17 Ankyrin-3 OS=Mus musculus GN=Ank3 PE=1 SV=1 PF05509//PF07992//PF00023//PF00731//PF13606//PF08498 TraY domain//Pyridine nucleotide-disulphide oxidoreductase//Ankyrin repeat//AIR carboxylase//Ankyrin repeat//Sterol methyltransferase C-terminal GO:0006694//GO:0055114//GO:0000746//GO:0006189 steroid biosynthetic process//oxidation-reduction process//conjugation//'de novo' IMP biosynthetic process GO:0008168//GO:0003677//GO:0016491//GO:0005515 methyltransferase activity//DNA binding//oxidoreductase activity//protein binding -- -- -- -- Cluster-8309.12382 BP_3 10.35 0.69 1010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12384 BP_3 4266.93 32.24 6671 86515338 NP_001034491.1 5709 0.0e+00 chitin synthase 1 [Tribolium castaneum]>gi|33867319|gb|AAQ55060.1| chitin synthase CHS1B [Tribolium castaneum]>gi|34148368|gb|AAQ62694.1| chitin synthase variant 2 [Tribolium castaneum] 627401361 KF147149.1 1087 0 Anthonomus grandis chitin synthase I (CHS1) mRNA, complete cds K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q4P9K9 230 3.8e-17 Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=CHS8 PE=3 SV=1 PF04689 DNA binding protein S1FA GO:0006031//GO:0006355 chitin biosynthetic process//regulation of transcription, DNA-templated GO:0004100//GO:0003677 chitin synthase activity//DNA binding GO:0005634 nucleus KOG2571 Chitin synthase/hyaluronan synthase (glycosyltransferases) Cluster-8309.12386 BP_3 15.10 0.74 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.12387 BP_3 40.69 0.88 2522 642919719 XP_008192036.1 309 2.4e-25 PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919721|ref|XP_008192037.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919723|ref|XP_008192039.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|270005423|gb|EFA01871.1| hypothetical protein TcasGA2_TC007476 [Tribolium castaneum] -- -- -- -- -- K17479 GRXCR1 glutaredoxin domain-containing cysteine-rich protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17479 Q9VNL4 264 1.6e-21 Glutaredoxin domain-containing cysteine-rich protein CG31559 OS=Drosophila melanogaster GN=CG31559 PE=1 SV=2 PF00684 DnaJ central domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0051082//GO:0009055//GO:0031072 protein disulfide oxidoreductase activity//unfolded protein binding//electron carrier activity//heat shock protein binding -- -- KOG2824 Glutaredoxin-related protein Cluster-8309.12388 BP_3 117.00 5.78 1268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12391 BP_3 82.33 0.78 5348 642920993 XP_008192643.1 2970 0.0e+00 PREDICTED: otopetrin-2 isoform X1 [Tribolium castaneum]>gi|270006154|gb|EFA02602.1| hypothetical protein TcasGA2_TC008321 [Tribolium castaneum] 768413017 XM_011570309.1 246 4.32201e-123 PREDICTED: Plutella xylostella otopetrin-2 (LOC105398248), mRNA -- -- -- -- Q7JWG9 257 2.3e-20 39S ribosomal protein L52, mitochondrial OS=Drosophila melanogaster GN=mRpL52 PE=2 SV=1 PF06783//PF04689 Uncharacterised protein family (UPF0239)//DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.12395 BP_3 34.07 0.85 2226 642929412 XP_008195828.1 2495 7.1e-279 PREDICTED: uncharacterized protein LOC663405 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12396 BP_3 15.23 0.31 2684 642929410 XP_008195826.1 895 2.9e-93 PREDICTED: uncharacterized protein LOC663405 isoform X1 [Tribolium castaneum]>gi|270009626|gb|EFA06074.1| hypothetical protein TcasGA2_TC008910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JXX2 194 2.3e-13 cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila grimshawi GN=Pde6 PE=3 SV=1 PF00015//PF05313 Methyl-accepting chemotaxis protein (MCP) signalling domain//Poxvirus P21 membrane protein GO:0007165 signal transduction GO:0004871 signal transducer activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.12397 BP_3 13.66 0.42 1868 642929414 XP_008195829.1 800 2.1e-82 PREDICTED: uncharacterized protein LOC663405 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05313 Poxvirus P21 membrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.1240 BP_3 6.98 0.83 699 642923040 XP_973485.2 546 2.2e-53 PREDICTED: transmembrane protein 164 [Tribolium castaneum]>gi|642923042|ref|XP_008200506.1| PREDICTED: transmembrane protein 164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U3C3 253 8.6e-21 Transmembrane protein 164 OS=Homo sapiens GN=TMEM164 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12405 BP_3 22.00 1.06 1295 478256669 ENN76851.1 163 1.1e-08 hypothetical protein YQE_06692, partial [Dendroctonus ponderosae]>gi|546676036|gb|ERL87121.1| hypothetical protein D910_04521 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006560//GO:0006525//GO:0006090//GO:0071436//GO:0006814 proline metabolic process//arginine metabolic process//pyruvate metabolic process//sodium ion export//sodium ion transport GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.12407 BP_3 5.00 0.38 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12408 BP_3 492.42 23.61 1297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12410 BP_3 6.00 0.35 1129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.12411 BP_3 1.46 0.41 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12416 BP_3 41.77 0.50 4308 642913527 XP_008201051.1 2518 2.9e-281 PREDICTED: protein timeless homolog [Tribolium castaneum]>gi|270002773|gb|EEZ99220.1| timeout [Tribolium castaneum] -- -- -- -- -- K03155 TIMELESS timeless http://www.genome.jp/dbget-bin/www_bget?ko:K03155 Q9UNS1 1419 3.3e-155 Protein timeless homolog OS=Homo sapiens GN=TIMELESS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1974 DNA topoisomerase I-interacting protein Cluster-8309.12418 BP_3 165.01 2.00 4261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12419 BP_3 6.10 0.64 748 270003368 EEZ99815.1 323 1.7e-27 hypothetical protein TcasGA2_TC002595 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 304 1.1e-26 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12420 BP_3 59.57 1.00 3165 322779294 EFZ09583.1 890 1.3e-92 hypothetical protein SINV_11475, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09280 XPC-binding domain GO:0006289//GO:0006281//GO:0043161 nucleotide-excision repair//DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process GO:0003684 damaged DNA binding -- -- -- -- Cluster-8309.12422 BP_3 39.29 0.38 5321 322779294 EFZ09583.1 890 2.2e-92 hypothetical protein SINV_11475, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12425 BP_3 7256.00 327.08 1361 332374168 AEE62225.1 386 1.5e-34 unknown [Dendroctonus ponderosae]>gi|478258063|gb|ENN78201.1| hypothetical protein YQE_05353, partial [Dendroctonus ponderosae]>gi|546682562|gb|ERL92485.1| hypothetical protein D910_09798 [Dendroctonus ponderosae]>gi|828177629|gb|AKK25138.1| odorant binding protein 13 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P54193 144 7.3e-08 General odorant-binding protein 83a OS=Drosophila melanogaster GN=Obp83a PE=1 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.12426 BP_3 208.00 7.56 1617 291170322 ADD82417.1 213 2.1e-14 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27017 135 9.6e-07 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.1243 BP_3 10.16 0.36 1656 768431183 XP_011556856.1 1406 9.9e-153 PREDICTED: carbonic anhydrase-related protein 10 [Plutella xylostella] 642920813 XM_008194349.1 496 0 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC661205), mRNA -- -- -- -- Q5R4U0 676 1.8e-69 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.12431 BP_3 92.52 4.66 1248 642919326 XP_008191826.1 1123 4.9e-120 PREDICTED: alkylated DNA repair protein alkB homolog 1 [Tribolium castaneum] -- -- -- -- -- K10765 ALKBH1 alkylated DNA repair protein alkB homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10765 P0CB42 524 5.8e-52 Alkylated DNA repair protein alkB homolog 1 OS=Mus musculus GN=Alkbh1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2731 DNA alkylation damage repair protein Cluster-8309.12435 BP_3 3.00 0.35 702 642911411 XP_008199411.1 917 2.1e-96 PREDICTED: lachesin-like isoform X1 [Tribolium castaneum] 642911412 XM_008201190.1 220 1.54453e-109 PREDICTED: Tribolium castaneum lachesin-like (LOC661289), transcript variant X2, mRNA -- -- -- -- Q24372 222 3.4e-17 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895//PF04655 Immunoglobulin domain//Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468//GO:0019748 protein phosphorylation//secondary metabolic process GO:0005515//GO:0016773 protein binding//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.12436 BP_3 18.87 0.49 2130 282392019 NP_001164153.1 156 1.1e-07 fibroblast growth factor 8 precursor [Tribolium castaneum]>gi|270002739|gb|EEZ99186.1| fibroblast growth factor 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13411 MerR HTH family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.12439 BP_3 56.00 4.83 851 91088485 XP_975796.1 199 4.6e-13 PREDICTED: uncharacterized protein LOC658401 [Tribolium castaneum]>gi|270011723|gb|EFA08171.1| hypothetical protein TcasGA2_TC005795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12441 BP_3 49.45 0.70 3703 642922794 XP_008193328.1 1466 2.4e-159 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 801 1.3e-83 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.12442 BP_3 7.01 0.61 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12443 BP_3 13.00 2.23 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12444 BP_3 19.14 1.30 1001 478258112 ENN78250.1 611 9.2e-61 hypothetical protein YQE_05401, partial [Dendroctonus ponderosae] -- -- -- -- -- K16610 TTLL15 tubulin monoglycylase TTLL15 http://www.genome.jp/dbget-bin/www_bget?ko:K16610 -- -- -- -- PF07478//PF03133 D-ala D-ala ligase C-terminus//Tubulin-tyrosine ligase family GO:0006464//GO:0009252//GO:0046436 cellular protein modification process//peptidoglycan biosynthetic process//D-alanine metabolic process GO:0008716 D-alanine-D-alanine ligase activity -- -- -- -- Cluster-8309.12445 BP_3 16.35 0.63 1550 156465583 ABU68110.1 1458 8.7e-159 MHC class I antigen [Macaca mulatta] 39644689 BC004489.2 1156 0 Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone IMAGE:3678099), partial cds K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P30515 1317 8.0e-144 Saoe class I histocompatibility antigen, A alpha chain OS=Saguinus oedipus PE=2 SV=1 PF00129//PF16497//PF06623 Class I Histocompatibility antigen, domains alpha 1 and 2//MHC-I family domain//MHC_I C-terminus GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- -- -- -- -- Cluster-8309.12446 BP_3 186.56 10.36 1160 91087671 XP_976426.1 355 5.2e-31 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12447 BP_3 27.96 1.26 1363 642930333 XP_008196351.1 720 2.9e-73 PREDICTED: protein Wnt-7b [Tribolium castaneum] -- -- -- -- -- K00572 WNT7 wingless-type MMTV integration site family, member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00572 P28465 476 2.3e-46 Protein Wnt-2 OS=Drosophila melanogaster GN=Wnt2 PE=2 SV=2 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.12449 BP_3 87.00 15.92 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12450 BP_3 35.79 4.25 698 91083847 XP_973942.1 365 2.1e-32 PREDICTED: endocuticle structural glycoprotein SgAbd-2 [Tribolium castaneum]>gi|270007939|gb|EFA04387.1| hypothetical protein TcasGA2_TC014685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 276 1.8e-23 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12451 BP_3 20.82 1.02 1277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04189 Gcd10p family GO:0030488 tRNA methylation -- -- GO:0031515 tRNA (m1A) methyltransferase complex -- -- Cluster-8309.12454 BP_3 10.00 0.33 1748 270011590 EFA08038.1 521 4.4e-50 hypothetical protein TcasGA2_TC005627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1246 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12461 BP_3 11.00 0.41 1597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03298 Stanniocalcin family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.12465 BP_3 1.00 0.32 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12467 BP_3 53.09 1.08 2651 270016446 EFA12892.1 1400 7.9e-152 hypothetical protein TcasGA2_TC004406 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q7Z2H8 746 2.2e-77 Proton-coupled amino acid transporter 1 OS=Homo sapiens GN=SLC36A1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.12472 BP_3 105.10 2.17 2622 270003223 EEZ99670.1 1702 7.5e-187 hypothetical protein TcasGA2_TC002427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12473 BP_3 13.28 0.64 1300 150416593 ABF60889.2 192 4.6e-12 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01543 Hepatitis C virus capsid protein -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.1248 BP_3 22.00 0.54 2263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12481 BP_3 5.00 1.21 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12488 BP_3 2.00 8.34 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10716 NADH dehydrogenase transmembrane subunit GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor -- -- -- -- Cluster-8309.1249 BP_3 4.00 0.44 733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12493 BP_3 1.00 2.87 282 290909033 ADD70031.1 141 8.1e-07 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00715//PF01395 Interleukin 2//PBP/GOBP family GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0005134//GO:0008083//GO:0005549 interleukin-2 receptor binding//growth factor activity//odorant binding GO:0005576//GO:0005893 extracellular region//interleukin-2 receptor complex -- -- Cluster-8309.12495 BP_3 6.00 0.38 1061 19526442 AAL89717.1 1279 3.4e-138 cathepsin B [Apriona germari] 19526441 AF483623.1 390 0 Apriona germari cathepsin B mRNA, complete cds K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P00787 719 1.2e-74 Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1 SV=2 PF08127//PF03051//PF00112 Peptidase family C1 propeptide//Peptidase C1-like family//Papain family cysteine protease GO:0050790//GO:0006508 regulation of catalytic activity//proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.12499 BP_3 45.00 3.64 888 329762922 AEC04842.1 411 1.3e-37 chemosensory protein [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q9W1C9 334 4.4e-30 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12500 BP_3 14.00 0.44 1833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12504 BP_3 721.07 11.36 3351 755945580 XP_011299844.1 1088 1.5e-115 PREDICTED: basic proline-rich protein-like [Fopius arisanus]>gi|755945583|ref|XP_011299845.1| PREDICTED: basic proline-rich protein-like [Fopius arisanus] -- -- -- -- -- -- -- -- -- Q04118 217 6.2e-16 Basic salivary proline-rich protein 3 OS=Homo sapiens GN=PRB3 PE=1 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.12505 BP_3 53.00 3.73 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12507 BP_3 3.00 1.63 378 270009438 EFA05886.1 244 1.2e-18 hypothetical protein TcasGA2_TC008698 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1251 BP_3 32.00 1.70 1197 149675211 ABR27687.1 1423 7.7e-155 cuticle proprotein proCP5.2 [Callinectes sapidus] 149675210 EF639839.1 811 0 Callinectes sapidus cuticle proprotein proCP5.2 mRNA, complete cds -- -- -- -- P81580 364 2.0e-33 Cuticle protein CP1158 OS=Cancer pagurus PE=1 SV=1 PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12511 BP_3 12.39 1.89 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12517 BP_3 141.55 13.14 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12521 BP_3 2.00 0.38 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12522 BP_3 21.69 0.32 3592 642929013 XP_008195655.1 1308 5.0e-141 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Tribolium castaneum] 759111195 XM_011357078.1 54 1.56172e-16 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K06125 COQ2 4-hydroxybenzoate polyprenyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06125 Q16QL3 1096 7.8e-118 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Aedes aegypti GN=coq2 PE=3 SV=1 PF02366//PF01040 Dolichyl-phosphate-mannose-protein mannosyltransferase//UbiA prenyltransferase family GO:0006493 protein O-linked glycosylation GO:0004659//GO:0000030 prenyltransferase activity//mannosyltransferase activity GO:0000136//GO:0016020//GO:0016021 alpha-1,6-mannosyltransferase complex//membrane//integral component of membrane KOG1381 Para-hydroxybenzoate-polyprenyl transferase Cluster-8309.12524 BP_3 285.69 4.57 3305 642916496 XP_008191066.1 1558 4.7e-170 PREDICTED: elongation factor Tu GTP-binding domain-containing protein 1 [Tribolium castaneum]>gi|270003614|gb|EFA00062.1| hypothetical protein TcasGA2_TC002875 [Tribolium castaneum] -- -- -- -- -- K14536 RIA1 ribosome assembly protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14536 Q7Z2Z2 739 1.8e-76 Elongation factor Tu GTP-binding domain-containing protein 1 OS=Homo sapiens GN=EFTUD1 PE=1 SV=2 PF00071//PF03764//PF00503//PF08477//PF02961//PF03144 Ras family//Elongation factor G, domain IV//G-protein alpha subunit//Ras of Complex, Roc, domain of DAPkinase//Barrier to autointegration factor//Elongation factor Tu domain 2 GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0019001//GO:0004871//GO:0003677//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//DNA binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0467 Translation elongation factor 2/ribosome biogenesis protein RIA1 and related proteins Cluster-8309.12526 BP_3 61.58 5.81 803 91080431 XP_968599.1 301 6.5e-25 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05715 Piccolo Zn-finger -- -- GO:0046872 metal ion binding GO:0045202 synapse -- -- Cluster-8309.1253 BP_3 38.00 1.01 2099 91091770 XP_966678.1 1578 1.4e-172 PREDICTED: S-adenosylmethionine synthase isoform X1 [Tribolium castaneum] 731227747 XM_010629558.1 202 4.83882e-99 PREDICTED: Fukomys damarensis methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 P40320 1519 4.1e-167 S-adenosylmethionine synthase OS=Drosophila melanogaster GN=Sam-S PE=2 SV=2 PF02772//PF02773//PF00438 S-adenosylmethionine synthetase, central domain//S-adenosylmethionine synthetase, C-terminal domain//S-adenosylmethionine synthetase, N-terminal domain GO:0006556//GO:0006555 S-adenosylmethionine biosynthetic process//methionine metabolic process GO:0004478 methionine adenosyltransferase activity -- -- KOG1506 S-adenosylmethionine synthetase Cluster-8309.12531 BP_3 23.00 2.41 752 -- -- -- -- -- 462283408 APGK01056946.1 48 6.82997e-14 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12532 BP_3 4384.91 85.18 2773 270012124 EFA08572.1 1362 2.1e-147 hypothetical protein TcasGA2_TC006227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI23 438 1.2e-41 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.12536 BP_3 9.41 0.37 1504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12537 BP_3 20200.93 1020.34 1246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07462 Merozoite surface protein 1 (MSP1) C-terminus GO:0009405 pathogenesis -- -- GO:0016020 membrane -- -- Cluster-8309.12538 BP_3 2335.00 61.42 2124 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1254 BP_3 7.00 0.97 639 195457552 XP_002075613.1 170 8.0e-10 GK18549 [Drosophila willistoni]>gi|194171698|gb|EDW86599.1| GK18549 [Drosophila willistoni] -- -- -- -- -- -- -- -- -- Q03276 136 2.9e-07 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Fragment) OS=Popillia japonica PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12540 BP_3 104.62 3.71 1652 546681071 ERL91227.1 800 1.8e-82 hypothetical protein D910_08563 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7Z156 381 2.9e-35 Venom allergen 5 OS=Polybia scutellaris rioplatensis PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3017 Defense-related protein containing SCP domain Cluster-8309.12543 BP_3 85.03 0.81 5349 642933323 XP_008197368.1 1156 3.1e-123 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 668 5.0e-68 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644//PF02166 Glycosyl hydrolase family 85//Androgen receptor GO:0007165//GO:0030521//GO:0006355 signal transduction//androgen receptor signaling pathway//regulation of transcription, DNA-templated GO:0004882//GO:0003677//GO:0033925//GO:0005496 androgen receptor activity//DNA binding//mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity//steroid binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.12544 BP_3 291.99 19.90 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- -- -- Cluster-8309.12546 BP_3 23.00 0.58 2189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.12547 BP_3 3023.20 94.18 1839 270015076 EFA11524.1 469 4.9e-44 hypothetical protein TcasGA2_TC014239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01186//PF09726 Lysyl oxidase//Transmembrane protein GO:0055114 oxidation-reduction process GO:0016641//GO:0005507 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//copper ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.12552 BP_3 724.00 213.22 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12553 BP_3 64.00 42.71 360 642930000 XP_008196060.1 339 1.1e-29 PREDICTED: calphotin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 277 7.2e-24 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12556 BP_3 15857.00 123.41 6485 642928525 XP_008193828.1 723 6.1e-73 PREDICTED: mucin-4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12557 BP_3 12.58 1.49 699 768411843 XP_011565977.1 353 5.3e-31 PREDICTED: protein yellow [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q9BI23 141 8.3e-08 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12558 BP_3 10.00 0.99 781 478253541 ENN73859.1 190 4.7e-12 hypothetical protein YQE_09551, partial [Dendroctonus ponderosae]>gi|546685413|gb|ERL94926.1| hypothetical protein D910_12198 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12559 BP_3 10.00 2.38 494 805812681 XP_012147725.1 275 4.1e-22 PREDICTED: uncharacterized protein LOC105663445, partial [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12561 BP_3 697.50 6.09 5809 478251276 ENN71747.1 2015 8.4e-223 hypothetical protein YQE_11567, partial [Dendroctonus ponderosae] 159484014 XM_001700004.1 35 9.24876e-06 Chlamydomonas reinhardtii strain CC-503 cw92 mt+ K18164 NDUFAF7 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18164 Q5XI79 955 2.8e-101 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 OS=Rattus norvegicus GN=Ndufaf7 PE=2 SV=1 PF10192//PF06814 Rhodopsin-like GPCR transmembrane domain//Lung seven transmembrane receptor GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone -- -- GO:0016021 integral component of membrane KOG2901 Uncharacterized conserved protein Cluster-8309.12562 BP_3 26.58 1.38 1219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12567 BP_3 9.00 0.64 974 817212368 XP_012282361.1 338 4.0e-29 PREDICTED: endocuticle structural glycoprotein SgAbd-1-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q7M4F4 297 9.5e-26 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12568 BP_3 3.00 0.65 515 -- -- -- -- -- 768311754 CP010982.1 495 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- Q8TFF3 222 2.5e-17 Transcriptional activator hac1 OS=Hypocrea jecorina GN=hac1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12570 BP_3 2.00 0.33 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12571 BP_3 51.00 7.80 607 768444096 XP_011563889.1 314 1.5e-26 PREDICTED: larval cuticle protein LCP-17-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- O02387 243 1.1e-19 Larval cuticle protein LCP-17 OS=Bombyx mori GN=LCP17 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12573 BP_3 13.27 0.74 1154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12574 BP_3 24.34 1.81 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05969 Photosystem II complex subunit Ycf12 GO:0015979 photosynthesis -- -- GO:0009523//GO:0016021 photosystem II//integral component of membrane -- -- Cluster-8309.12577 BP_3 20.27 0.31 3401 156564353 NP_001096055.1 1250 2.5e-134 aspartate 1-decarboxylase [Tribolium castaneum]>gi|155675826|gb|ABU25221.1| aspartate 1-decarboxylase [Tribolium castaneum] -- -- -- -- -- K18966 GADL1, CSADC, ADC sulfinoalanine decarboxylase / aspartate 1-decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K18966 A6QM00 829 6.8e-87 Acidic amino acid decarboxylase GADL1 OS=Bos taurus GN=GADL1 PE=2 SV=2 PF01212//PF00282 Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain GO:0006531//GO:0019752//GO:0019482//GO:0006520//GO:0006523 aspartate metabolic process//carboxylic acid metabolic process//beta-alanine metabolic process//cellular amino acid metabolic process//alanine biosynthetic process GO:0030170//GO:0016831//GO:0016829//GO:0004068 pyridoxal phosphate binding//carboxy-lyase activity//lyase activity//aspartate 1-decarboxylase activity -- -- KOG0629 Glutamate decarboxylase and related proteins Cluster-8309.12578 BP_3 2041.92 35.20 3088 156564353 NP_001096055.1 2137 3.2e-237 aspartate 1-decarboxylase [Tribolium castaneum]>gi|155675826|gb|ABU25221.1| aspartate 1-decarboxylase [Tribolium castaneum] -- -- -- -- -- K01594 CSAD sulfinoalanine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01594 Q9Y600 1387 1.2e-151 Cysteine sulfinic acid decarboxylase OS=Homo sapiens GN=CSAD PE=1 SV=2 PF01276//PF01212//PF00282 Orn/Lys/Arg decarboxylase, major domain//Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain GO:0006531//GO:0019752//GO:0006523//GO:0019482//GO:0006520 aspartate metabolic process//carboxylic acid metabolic process//alanine biosynthetic process//beta-alanine metabolic process//cellular amino acid metabolic process GO:0003824//GO:0016831//GO:0030170//GO:0004068//GO:0016829 catalytic activity//carboxy-lyase activity//pyridoxal phosphate binding//aspartate 1-decarboxylase activity//lyase activity -- -- KOG0629 Glutamate decarboxylase and related proteins Cluster-8309.12581 BP_3 1.00 2.80 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12584 BP_3 10.00 0.81 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12586 BP_3 9.00 0.54 1094 325930039 ADZ45521.1 624 3.1e-62 GREBP [Homo sapiens] 893712365 KT250597.1 1094 0 Homo sapiens haplogroup H5a1 mitochondrion, complete genome K03879 ND2 NADH-ubiquinone oxidoreductase chain 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03879 P03891 492 2.6e-48 NADH-ubiquinone oxidoreductase chain 2 OS=Homo sapiens GN=MT-ND2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12587 BP_3 10.00 0.95 797 270010544 EFA06992.1 185 1.8e-11 hypothetical protein TcasGA2_TC009954 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1259 BP_3 138.84 4.31 1843 642936139 XP_008198314.1 1006 2.7e-106 PREDICTED: T-cell leukemia homeobox protein 2 [Tribolium castaneum]>gi|270014244|gb|EFA10692.1| hypothetical protein TcasGA2_TC011749 [Tribolium castaneum] 583976831 XM_006783706.1 36 8.056e-07 PREDICTED: Neolamprologus brichardi homeobox protein HMX2-like (LOC102779030), mRNA K15607 TLX3, HOX11L2 T-cell leukemia homeobox protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15607 O93367 470 1.6e-45 T-cell leukemia homeobox protein 3 OS=Gallus gallus GN=TLX3 PE=2 SV=1 PF00046//PF01346//PF05920 Homeobox domain//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Homeobox KN domain GO:0006355//GO:0006457 regulation of transcription, DNA-templated//protein folding GO:0003677 DNA binding -- -- -- -- Cluster-8309.12594 BP_3 94.43 7.93 866 642931265 XP_008196504.1 671 8.8e-68 PREDICTED: high mobility group B protein 13-like [Tribolium castaneum]>gi|270012132|gb|EFA08580.1| hypothetical protein TcasGA2_TC006235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03435 144 4.6e-08 Non-histone protein 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NHP10 PE=1 SV=1 PF00527 E7 protein, Early protein GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG0381 HMG box-containing protein Cluster-8309.12595 BP_3 2.00 0.57 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12596 BP_3 12.00 0.80 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12597 BP_3 4649.56 603.64 663 270003368 EEZ99815.1 364 2.7e-32 hypothetical protein TcasGA2_TC002595 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 326 2.8e-29 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12598 BP_3 1.00 1.25 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12601 BP_3 7.00 0.75 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12603 BP_3 26.62 0.89 1737 478256535 ENN76719.1 295 7.0e-24 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P18714 276 4.6e-23 Gastrula zinc finger protein xFG20-1 OS=Xenopus laevis PE=3 SV=2 PF13465//PF02891//PF02892//PF04810//PF13912//PF01363//PF07562//PF01428//PF16622//PF02176//PF00096//PF05495//PF00130//PF00628//PF06467 Zinc-finger double domain//MIZ/SP-RING zinc finger//BED zinc finger//Sec23/Sec24 zinc finger//C2H2-type zinc finger//FYVE zinc finger//Nine Cysteines Domain of family 3 GPCR//AN1-like Zinc finger//zinc-finger C2H2-type//TRAF-type zinc finger//Zinc finger, C2H2 type//CHY zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//MYM-type Zinc finger with FCS sequence motif GO:0035556//GO:0007186//GO:0006886//GO:0006888 intracellular signal transduction//G-protein coupled receptor signaling pathway//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0005515//GO:0004930//GO:0003677 metal ion binding//zinc ion binding//protein binding//G-protein coupled receptor activity//DNA binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.12607 BP_3 3.00 0.49 589 167444204 ABZ80663.1 346 2.9e-30 hypothetical antimicrobial peptide [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.12609 BP_3 334.65 2.28 7377 546679822 ERL90214.1 4055 0.0e+00 hypothetical protein D910_07567 [Dendroctonus ponderosae] 627401361 KF147149.1 852 0 Anthonomus grandis chitin synthase I (CHS1) mRNA, complete cds K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q4P9K9 230 4.2e-17 Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=CHS8 PE=3 SV=1 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG2571 Chitin synthase/hyaluronan synthase (glycosyltransferases) Cluster-8309.12612 BP_3 6.00 0.40 1022 31415567 AAP45006.1 913 9.0e-96 arylphorin-like hexameric storage protein 2 [Apriona germari] 31415566 AY293287.1 388 0 Apriona germari arylphorin-like hexameric storage protein 2 (Hex2) mRNA, complete cds -- -- -- -- P14296 345 2.7e-31 Arylphorin subunit alpha OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12613 BP_3 112.00 4.46 1503 31415567 AAP45006.1 2255 3.2e-251 arylphorin-like hexameric storage protein 2 [Apriona germari] 31415566 AY293287.1 753 0 Apriona germari arylphorin-like hexameric storage protein 2 (Hex2) mRNA, complete cds -- -- -- -- P14297 736 1.8e-76 Arylphorin subunit beta OS=Manduca sexta PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12617 BP_3 14.66 1.83 678 91087671 XP_976426.1 236 1.9e-17 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01396 Topoisomerase DNA binding C4 zinc finger GO:0006265 DNA topological change GO:0003677//GO:0003916 DNA binding//DNA topoisomerase activity GO:0005694 chromosome -- -- Cluster-8309.12619 BP_3 199.00 38.01 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12620 BP_3 12.00 2.22 552 478254324 ENN74578.1 146 4.2e-07 hypothetical protein YQE_08900, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12622 BP_3 8.46 1.00 700 607357601 EZA52050.1 427 1.4e-39 hypothetical protein X777_09071 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12626 BP_3 62.74 1.07 3106 270017042 EFA13488.1 1756 4.8e-193 hypothetical protein TcasGA2_TC004227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21329 392 2.9e-36 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila funebris GN=jockey\pol PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1263 BP_3 3.90 0.92 495 91080851 XP_971681.1 295 2.0e-24 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005416|gb|EFA01864.1| hypothetical protein TcasGA2_TC007467 [Tribolium castaneum] -- -- -- -- -- K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 Q9H172 221 3.1e-17 ATP-binding cassette sub-family G member 4 OS=Homo sapiens GN=ABCG4 PE=1 SV=2 -- -- GO:0006200 obsolete ATP catabolic process GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.12630 BP_3 41.00 1.43 1669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15826 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis GO:0097193//GO:0090200//GO:0043065 intrinsic apoptotic signaling pathway//positive regulation of release of cytochrome c from mitochondria//positive regulation of apoptotic process -- -- GO:0005739 mitochondrion -- -- Cluster-8309.12637 BP_3 8.11 0.34 1429 642912981 XP_008201337.1 924 6.7e-97 PREDICTED: calexcitin-1 isoform X1 [Tribolium castaneum] 157127291 XM_001654858.1 71 2.17166e-26 Aedes aegypti AAEL010792-RA partial mRNA -- -- -- -- Q10131 275 4.9e-23 Calexcitin-1 OS=Caenorhabditis elegans GN=cex-1 PE=3 SV=1 PF12763//PF09830//PF13499//PF13833//PF10591//PF13405//PF13202//PF00036 Cytoskeletal-regulatory complex EF hand//ATP adenylyltransferase//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF hand GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0005515//GO:0005509//GO:0003877 protein binding//calcium ion binding//ATP adenylyltransferase activity GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.12638 BP_3 2.00 4.24 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12639 BP_3 15.51 4.99 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12642 BP_3 394.00 141.69 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04120 Low affinity iron permease GO:0055085 transmembrane transport -- -- -- -- -- -- Cluster-8309.12643 BP_3 13.42 0.70 1216 91094905 XP_973449.1 1188 1.4e-127 PREDICTED: F-box/SPRY domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270006590|gb|EFA03038.1| hypothetical protein TcasGA2_TC010464 [Tribolium castaneum] 242007554 XM_002424560.1 186 2.17085e-90 Pediculus humanus corporis F-box/SPRY-domain protein, putative, mRNA K10319 FBXO45 F-box protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K10319 B4HQ29 1043 3.7e-112 F-box/SPRY domain-containing protein 1 OS=Drosophila sechellia GN=Fsn PE=3 SV=1 PF00646//PF00622//PF12937 F-box domain//SPRY domain//F-box-like -- -- GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.12644 BP_3 4.00 1.96 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12645 BP_3 12.00 1.81 612 748396488 KIH65593.1 188 6.3e-12 hypothetical protein ANCDUO_04087 [Ancylostoma duodenale] -- -- -- -- -- -- -- -- -- Q9LJ64 142 5.6e-08 Pollen-specific leucine-rich repeat extensin-like protein 1 OS=Arabidopsis thaliana GN=PEX1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12646 BP_3 118.00 4.09 1681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1265 BP_3 57.64 1.44 2219 91092776 XP_973805.1 1617 4.5e-177 PREDICTED: uncharacterized protein C4orf29 isoform X2 [Tribolium castaneum]>gi|270014895|gb|EFA11343.1| hypothetical protein TcasGA2_TC010883 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C1A9 1064 2.5e-114 Uncharacterized protein C4orf29 homolog OS=Mus musculus PE=2 SV=1 PF02129 X-Pro dipeptidyl-peptidase (S15 family) -- -- GO:0016787 hydrolase activity -- -- KOG1551 Uncharacterized conserved protein Cluster-8309.12652 BP_3 18.00 3.32 553 21617523 AAM66718.1 550 6.0e-54 larval cuticle protein 12.3 [Apriona germari] 21617522 AF518323.1 236 1.53051e-118 Apriona germari larval cuticle protein 12.3 (LCP12.3) mRNA, complete cds -- -- -- -- O02387 237 4.9e-19 Larval cuticle protein LCP-17 OS=Bombyx mori GN=LCP17 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12653 BP_3 13.76 0.47 1716 642931509 XP_968544.2 778 6.8e-80 PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|642931511|ref|XP_008196616.1| PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DC8 631 3.1e-64 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Homo sapiens GN=ECHDC3 PE=1 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.12654 BP_3 18.52 0.57 1859 642931509 XP_968544.2 791 2.3e-81 PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|642931511|ref|XP_008196616.1| PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DC8 628 7.5e-64 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Homo sapiens GN=ECHDC3 PE=1 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.12657 BP_3 16.86 0.91 1183 646706249 KDR13577.1 495 3.1e-47 cAMP-specific 3',5'-cyclic phosphodiesterase, partial [Zootermopsis nevadensis] 642935593 XM_008199853.1 101 3.76324e-43 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X15, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 Q8IRU4 289 9.7e-25 cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F OS=Drosophila melanogaster GN=dnc PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.12658 BP_3 5.75 0.33 1131 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12661 BP_3 32.00 2.04 1047 21617525 AAM66719.1 202 2.6e-13 larval cuticle protein 12.6 [Apriona germari] -- -- -- -- -- -- -- -- -- Q08738 180 3.8e-12 Larval cuticle protein LCP-30 OS=Bombyx mori GN=LCP30 PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12662 BP_3 6.00 1.41 496 546674048 ERL85536.1 142 1.1e-06 hypothetical protein D910_02955, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12669 BP_3 27.15 0.33 4201 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q914G7 343 1.9e-30 Uncharacterized protein 65 OS=Sulfolobus islandicus filamentous virus (isolate Iceland/Hveragerdi) GN=SIFV0065 PE=4 SV=1 PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.1267 BP_3 42.00 1.17 2029 795011741 XP_011874268.1 720 4.3e-73 PREDICTED: uncharacterized protein LOC105565573 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- O86236 130 4.6e-06 Uncharacterized transposase-like protein HI_1328.1 OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=HI_1328.1 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12672 BP_3 21.00 7.28 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12673 BP_3 45.11 1.24 2044 642929412 XP_008195828.1 555 5.8e-54 PREDICTED: uncharacterized protein LOC663405 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JXX2 194 1.7e-13 cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila grimshawi GN=Pde6 PE=3 SV=1 PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165 signal transduction GO:0004871 signal transducer activity GO:0016020 membrane -- -- Cluster-8309.12674 BP_3 15.00 0.32 2546 642929410 XP_008195826.1 839 8.5e-87 PREDICTED: uncharacterized protein LOC663405 isoform X1 [Tribolium castaneum]>gi|270009626|gb|EFA06074.1| hypothetical protein TcasGA2_TC008910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JXX2 194 2.2e-13 cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila grimshawi GN=Pde6 PE=3 SV=1 PF05313//PF00015 Poxvirus P21 membrane protein//Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165 signal transduction GO:0004871 signal transducer activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.12677 BP_3 16.50 0.46 2004 642933166 XP_008197284.1 1818 2.0e-200 PREDICTED: hexosaminidase D-like [Tribolium castaneum]>gi|270012547|gb|EFA08995.1| hypothetical protein TcasGA2_TC006702 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 731 9.2e-76 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- -- -- Cluster-8309.12679 BP_3 7.00 1.23 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12680 BP_3 18.00 4.81 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12683 BP_3 1.00 0.40 411 270013377 EFA09825.1 328 2.5e-28 hypothetical protein TcasGA2_TC011972 [Tribolium castaneum] -- -- -- -- -- K08635 MMEL1 membrane metallo-endopeptidase-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08635 O44857 241 1.2e-19 Neprilysin-2 OS=Caenorhabditis elegans GN=nep-2 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.1269 BP_3 61.79 3.51 1141 91088231 XP_973706.1 993 5.3e-105 PREDICTED: factor VIII intron 22 protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00558 214 4.7e-16 Factor VIII intron 22 protein OS=Mus musculus GN=F8a1 PE=2 SV=1 PF08656 DASH complex subunit Dad3 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.12695 BP_3 24.00 6.41 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12697 BP_3 4.00 0.56 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16331//PF06160 TolA binding protein trimerisation//Septation ring formation regulator, EzrA GO:0070206//GO:0000921 protein trimerization//septin ring assembly -- -- GO:0016021//GO:0005940 integral component of membrane//septin ring -- -- Cluster-8309.12699 BP_3 2.37 0.50 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225 helix-turn-helix, Psq domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.1270 BP_3 2.69 0.31 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12701 BP_3 53.66 3.31 1073 332376963 AEE63621.1 643 1.9e-64 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13220 WBP4, FBP21 WW domain-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13220 Q5HZF2 177 8.6e-12 WW domain-binding protein 4 OS=Rattus norvegicus GN=Wbp4 PE=2 SV=1 PF00397//PF06220 WW domain//U1 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0150 Spliceosomal protein FBP21 Cluster-8309.12703 BP_3 4.00 0.52 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12704 BP_3 145.18 2.64 2944 91076346 XP_966525.1 1658 1.1e-181 PREDICTED: leucine zipper putative tumor suppressor 2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4W1 429 1.4e-40 Leucine zipper putative tumor suppressor 2 homolog OS=Xenopus laevis GN=lzts2 PE=2 SV=1 PF10288//PF01008//PF00769 Cytoplasmic tRNA 2-thiolation protein 2//Initiation factor 2 subunit family//Ezrin/radixin/moesin family GO:0044237//GO:0002098//GO:0034227 cellular metabolic process//tRNA wobble uridine modification//tRNA thio-modification GO:0000049//GO:0008092 tRNA binding//cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane -- -- Cluster-8309.12706 BP_3 51.45 0.61 4357 675232298 CDU18069.1 165 2.1e-08 conserved Plasmodium protein, unknown function [Plasmodium yoelii] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00116 Cytochrome C oxidase subunit II, periplasmic domain GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0005507 cytochrome-c oxidase activity//copper ion binding GO:0045277//GO:0016020 respiratory chain complex IV//membrane -- -- Cluster-8309.12707 BP_3 108.38 5.78 1196 332374592 AEE62437.1 715 9.6e-73 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 391 1.5e-36 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.12709 BP_3 125.94 4.09 1776 91077290 XP_974504.1 296 5.5e-24 PREDICTED: synaptonemal complex protein 1 [Tribolium castaneum]>gi|270002764|gb|EEZ99211.1| IKK gamma [Tribolium castaneum] -- -- -- -- -- -- -- -- -- C5DJH6 163 6.0e-10 Spindle pole body component 110 OS=Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) GN=SPC110 PE=3 SV=1 PF13912//PF00038//PF00096 C2H2-type zinc finger//Intermediate filament protein//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005198 metal ion binding//structural molecule activity GO:0005882 intermediate filament -- -- Cluster-8309.12717 BP_3 1224.56 37.47 1867 828177654 AKK25149.1 338 7.8e-29 chemosensory protein 6 [Dendroctonus ponderosae] 462357473 APGK01030461.1 73 2.20628e-27 Dendroctonus ponderosae Seq01030471, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12718 BP_3 2751.58 114.60 1449 828177654 AKK25149.1 338 6.0e-29 chemosensory protein 6 [Dendroctonus ponderosae] 462357473 APGK01030461.1 73 1.70288e-27 Dendroctonus ponderosae Seq01030471, whole genome shotgun sequence -- -- -- -- Q9W1C9 126 9.5e-06 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12720 BP_3 10.00 4.25 404 158187796 ABW23187.1 373 1.5e-33 ribosomal protein rpl34 [Arenicola marina] 262401270 FJ774817.1 267 6.40288e-136 Scylla paramamosain putative 60S ribosomal protein RPL34 mRNA, partial cds K02915 RP-L34e, RPL34 large subunit ribosomal protein L34e http://www.genome.jp/dbget-bin/www_bget?ko:K02915 P45842 321 6.4e-29 60S ribosomal protein L34 OS=Aedes albopictus GN=RpL34 PE=2 SV=2 PF01199 Ribosomal protein L34e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1790 60s ribosomal protein L34 Cluster-8309.12721 BP_3 10.00 1.10 729 568250947 ETN60559.1 336 5.2e-29 mitochondrial ATP synthase coupling factor 6 [Anopheles darlingi] -- -- -- -- -- K02131 ATPeF0F6, ATP5J F-type H+-transporting ATPase subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02131 Q24407 259 1.8e-21 ATP synthase-coupling factor 6, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-Cf6 PE=3 SV=1 PF05511 Mitochondrial ATP synthase coupling factor 6 GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.12731 BP_3 31.55 0.34 4804 642920521 XP_008192385.1 973 4.7e-102 PREDICTED: uncharacterized protein LOC663775 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96BD5 189 1.6e-12 PHD finger protein 21A OS=Homo sapiens GN=PHF21A PE=1 SV=1 PF00628//PF15163 PHD-finger//Meiosis-expressed -- -- GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.12734 BP_3 70.01 3.02 1408 642920521 XP_008192385.1 1227 4.8e-132 PREDICTED: uncharacterized protein LOC663775 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96BD5 200 2.4e-14 PHD finger protein 21A OS=Homo sapiens GN=PHF21A PE=1 SV=1 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12736 BP_3 8.50 0.44 1220 91087015 XP_974102.1 495 3.2e-47 PREDICTED: protein phosphatase 1 regulatory subunit 21 [Tribolium castaneum]>gi|270009633|gb|EFA06081.1| hypothetical protein TcasGA2_TC008917 [Tribolium castaneum] -- -- -- -- -- K17562 PPP1R21, CCDC128, KLRAQ1 protein phosphatase 1 regulatory subunit 21 http://www.genome.jp/dbget-bin/www_bget?ko:K17562 Q5ZL12 264 7.9e-22 Protein phosphatase 1 regulatory subunit 21 OS=Gallus gallus GN=PPP1R21 PE=2 SV=1 PF04977//PF12639//PF08702 Septum formation initiator//DNase/tRNase domain of colicin-like bacteriocin//Fibrinogen alpha/beta chain family GO:0030168//GO:0007049//GO:0007165//GO:0051258 platelet activation//cell cycle//signal transduction//protein polymerization GO:0030674//GO:0005102//GO:0004519 protein binding, bridging//receptor binding//endonuclease activity GO:0005577 fibrinogen complex -- -- Cluster-8309.12745 BP_3 7.00 0.93 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12747 BP_3 286.83 9.33 1774 91094671 XP_972558.1 2090 5.1e-232 PREDICTED: USP6 N-terminal-like protein isoform X1 [Tribolium castaneum] 827555134 XM_012693612.1 128 5.58088e-58 PREDICTED: Bombyx mori USP6 N-terminal-like protein (LOC101746723), mRNA -- -- -- -- Q80XC3 1096 3.9e-118 USP6 N-terminal-like protein OS=Mus musculus GN=Usp6nl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.1275 BP_3 9.00 0.48 1196 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12753 BP_3 8.00 0.60 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12754 BP_3 496.44 31.10 1061 189242304 XP_001808377.1 648 5.0e-65 PREDICTED: uncharacterized protein LOC100141613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12758 BP_3 2.00 0.57 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12764 BP_3 26.27 1.66 1056 570341948 AHE77372.1 494 3.6e-47 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 285 2.5e-24 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.12767 BP_3 311.86 2.48 6364 642913900 XP_008201205.1 5742 0.0e+00 PREDICTED: anaphase-promoting complex subunit 1 [Tribolium castaneum] -- -- -- -- -- K03348 APC1 anaphase-promoting complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03348 Q9H1A4 2718 1.2e-305 Anaphase-promoting complex subunit 1 OS=Homo sapiens GN=ANAPC1 PE=1 SV=1 PF12859//PF07475 Anaphase-promoting complex subunit 1//HPr Serine kinase C-terminal domain GO:0016310//GO:0006109//GO:0000160 phosphorylation//regulation of carbohydrate metabolic process//phosphorelay signal transduction system GO:0004672//GO:0000155//GO:0005524 protein kinase activity//phosphorelay sensor kinase activity//ATP binding GO:0009365//GO:0005680 protein histidine kinase complex//anaphase-promoting complex KOG1858 Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) Cluster-8309.12771 BP_3 51.86 0.91 3026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12774 BP_3 24.00 1.19 1263 642937652 XP_966876.3 626 2.1e-62 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01611 354 3.0e-32 Zinc finger Y-chromosomal protein 1 OS=Xenopus laevis GN=zfy1 PE=2 SV=1 PF08273//PF00096//PF13465//PF00462//PF02150 Zinc-binding domain of primase-helicase//Zinc finger, C2H2 type//Zinc-finger double domain//Glutaredoxin//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006206//GO:0045454//GO:0006269//GO:0006118 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//cell redox homeostasis//DNA replication, synthesis of RNA primer//obsolete electron transport GO:0003677//GO:0004386//GO:0015035//GO:0009055//GO:0046872//GO:0003896//GO:0003899//GO:0008270 DNA binding//helicase activity//protein disulfide oxidoreductase activity//electron carrier activity//metal ion binding//DNA primase activity//DNA-directed RNA polymerase activity//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.12776 BP_3 36.55 1.37 1578 478260276 ENN80028.1 233 9.8e-17 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q95LI3 152 1.0e-08 Zinc finger Y-chromosomal protein OS=Bos taurus GN=ZFY PE=2 SV=1 PF02150//PF13465//PF00096//PF09599//PF07776 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//Salmonella-Shigella invasin protein C (IpaC_SipC)//Zinc-finger associated domain (zf-AD) GO:0009405//GO:0006351//GO:0006144//GO:0006206 pathogenesis//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus KOG1721 FOG: Zn-finger Cluster-8309.12777 BP_3 30.92 0.60 2780 642937652 XP_966876.3 696 3.6e-70 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17012 373 4.2e-34 Zinc finger X-chromosomal protein OS=Mus musculus GN=Zfx PE=1 SV=2 PF00096//PF13465//PF02150//PF00130//PF09505//PF04196 Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit//Phorbol esters/diacylglycerol binding domain (C1 domain)//Dimethylamine methyltransferase (Dimeth_PyL)//Bunyavirus RNA dependent RNA polymerase GO:0015948//GO:0019079//GO:0006351//GO:0006144//GO:0006206//GO:0035556 methanogenesis//viral genome replication//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//intracellular signal transduction GO:0003899//GO:0003677//GO:0008168//GO:0003968//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//methyltransferase activity//RNA-directed RNA polymerase activity//metal ion binding GO:0031379//GO:0005730 RNA-directed RNA polymerase complex//nucleolus -- -- Cluster-8309.12778 BP_3 49.28 0.56 4501 642910200 XP_008198377.1 2265 6.7e-252 PREDICTED: N-alpha-acetyltransferase 35, NatC auxiliary subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZHV2 1542 1.9e-169 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Gallus gallus GN=NAA35 PE=2 SV=1 PF08287//PF01442//PF08336 Spc19//Apolipoprotein A1/A4/E domain//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0055114//GO:0008608//GO:0006560//GO:0006869//GO:0042157//GO:0018401//GO:0006525 oxidation-reduction process//attachment of spindle microtubules to kinetochore//proline metabolic process//lipid transport//lipoprotein metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process GO:0016702//GO:0008289//GO:0004656 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//lipid binding//procollagen-proline 4-dioxygenase activity GO:0005876//GO:0042729//GO:0005576//GO:0005783 spindle microtubule//DASH complex//extracellular region//endoplasmic reticulum KOG2343 Glucose-repressible protein and related proteins Cluster-8309.12780 BP_3 49.97 0.57 4532 694974029 XP_009433421.1 406 2.5e-36 PREDICTED: zinc finger protein 429 isoform X3 [Pan troglodytes] -- -- -- -- -- -- -- -- -- Q8N184 409 4.5e-38 Zinc finger protein 567 OS=Homo sapiens GN=ZNF567 PE=1 SV=3 PF07776//PF06467//PF00096//PF00569//PF01155//PF06397//PF13912//PF05485//PF16622//PF13465//PF05151//PF02146//PF07975 Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C2H2 type//Zinc finger, ZZ type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Desulfoferrodoxin, N-terminal domain//C2H2-type zinc finger//THAP domain//zinc-finger C2H2-type//Zinc-finger double domain//Photosystem II reaction centre M protein (PsbM)//Sir2 family//TFIIH C1-like domain GO:0006281//GO:0015979//GO:0006464//GO:0019684 DNA repair//photosynthesis//cellular protein modification process//photosynthesis, light reaction GO:0070403//GO:0016151//GO:0005506//GO:0046872//GO:0003676//GO:0008270 NAD+ binding//nickel cation binding//iron ion binding//metal ion binding//nucleic acid binding//zinc ion binding GO:0016021//GO:0005634//GO:0009523 integral component of membrane//nucleus//photosystem II -- -- Cluster-8309.12783 BP_3 54.02 1.72 1809 91079028 XP_974924.1 1752 8.2e-193 PREDICTED: glutamate-rich WD repeat-containing protein 1 [Tribolium castaneum]>gi|270004178|gb|EFA00626.1| hypothetical protein TcasGA2_TC003502 [Tribolium castaneum] 687865299 LK927543.1 35 2.84297e-06 Caenorhabditis elegans genome assembly C_elegans_Bristol_N2_v1_5_4 ,scaffold CELN2_scaffold0000013 K14848 RRB1, GRWD1 ribosome assembly protein RRB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14848 Q9BQ67 1160 1.5e-125 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens GN=GRWD1 PE=1 SV=1 PF00400//PF08676 WD domain, G-beta repeat//MutL C terminal dimerisation domain GO:0006298 mismatch repair GO:0005524//GO:0005515 ATP binding//protein binding GO:0005634 nucleus KOG0302 Ribosome Assembly protein Cluster-8309.12785 BP_3 13.73 0.44 1793 642937581 XP_008199107.1 837 1.0e-86 PREDICTED: zinc finger and BTB domain-containing protein 12-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B87 360 8.6e-33 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12786 BP_3 17.00 0.37 2497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12787 BP_3 64.27 1.14 3018 642924466 XP_001813222.2 1512 9.3e-165 PREDICTED: peroxisome biogenesis protein 1 [Tribolium castaneum]>gi|270007904|gb|EFA04352.1| hypothetical protein TcasGA2_TC014648 [Tribolium castaneum] 195378559 XM_002048015.1 51 6.0931e-15 Drosophila virilis GJ13751 (Dvir\GJ13751), mRNA K13338 PEX1 peroxin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K13338 O43933 883 3.3e-93 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 PF07724//PF00004//PF05496//PF06068//PF01695//PF07728//PF02562//PF09262 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//PhoH-like protein//Peroxisome biogenesis factor 1, N-terminal GO:0006310//GO:0006281//GO:0007031 DNA recombination//DNA repair//peroxisome organization GO:0009378//GO:0016887//GO:0003678//GO:0005524 four-way junction helicase activity//ATPase activity//DNA helicase activity//ATP binding GO:0005777//GO:0009379//GO:0005657 peroxisome//Holliday junction helicase complex//replication fork KOG0735 AAA+-type ATPase Cluster-8309.12789 BP_3 67.41 1.16 3084 642924466 XP_001813222.2 1747 5.3e-192 PREDICTED: peroxisome biogenesis protein 1 [Tribolium castaneum]>gi|270007904|gb|EFA04352.1| hypothetical protein TcasGA2_TC014648 [Tribolium castaneum] 195378559 XM_002048015.1 51 6.22796e-15 Drosophila virilis GJ13751 (Dvir\GJ13751), mRNA K13338 PEX1 peroxin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K13338 O43933 883 3.4e-93 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 PF07724//PF00437//PF05496//PF01443//PF06068//PF00910//PF00493//PF00005//PF03193//PF03266//PF07726//PF00004//PF00158//PF01926//PF01695//PF07728//PF00931//PF01580//PF02562//PF02367//PF06414//PF09262 AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//TIP49 C-terminus//RNA helicase//MCM2/3/5 family//ABC transporter//Protein of unknown function, DUF258//NTPase//ATPase family associated with various cellular activities (AAA)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//50S ribosome-binding GTPase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//NB-ARC domain//FtsK/SpoIIIE family//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Peroxisome biogenesis factor 1, N-terminal GO:0007031//GO:0002949//GO:0006310//GO:0006810//GO:0006281//GO:0006355//GO:0006260 peroxisome organization//tRNA threonylcarbamoyladenosine modification//DNA recombination//transport//DNA repair//regulation of transcription, DNA-templated//DNA replication GO:0003678//GO:0003723//GO:0003677//GO:0043531//GO:0005525//GO:0009378//GO:0003724//GO:0005524//GO:0098519//GO:0008134//GO:0003924//GO:0000166//GO:0016301//GO:0016887 DNA helicase activity//RNA binding//DNA binding//ADP binding//GTP binding//four-way junction helicase activity//RNA helicase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//GTPase activity//nucleotide binding//kinase activity//ATPase activity GO:0005657//GO:0005777//GO:0005667//GO:0009379 replication fork//peroxisome//transcription factor complex//Holliday junction helicase complex KOG0735 AAA+-type ATPase Cluster-8309.12790 BP_3 30.78 0.52 3153 642924466 XP_001813222.2 1146 2.7e-122 PREDICTED: peroxisome biogenesis protein 1 [Tribolium castaneum]>gi|270007904|gb|EFA04352.1| hypothetical protein TcasGA2_TC014648 [Tribolium castaneum] 195378559 XM_002048015.1 51 6.36895e-15 Drosophila virilis GJ13751 (Dvir\GJ13751), mRNA K13338 PEX1 peroxin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K13338 O43933 739 1.7e-76 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 PF05496//PF06068//PF01695//PF07728//PF05965//PF07724//PF00004//PF02562//PF02367//PF09262 Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//F/Y rich C-terminus//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Peroxisome biogenesis factor 1, N-terminal GO:0006310//GO:0002949//GO:0007031//GO:0006281 DNA recombination//tRNA threonylcarbamoyladenosine modification//peroxisome organization//DNA repair GO:0016887//GO:0009378//GO:0003678//GO:0005524 ATPase activity//four-way junction helicase activity//DNA helicase activity//ATP binding GO:0005634//GO:0009379//GO:0005657//GO:0005777 nucleus//Holliday junction helicase complex//replication fork//peroxisome KOG0735 AAA+-type ATPase Cluster-8309.12794 BP_3 33.91 0.50 3545 642915652 XP_008190697.1 1054 1.4e-111 PREDICTED: integrin-alpha FG-GAP repeat-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- K09648 IMP2 mitochondrial inner membrane protease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09648 Q6AZD4 491 1.1e-47 Mitochondrial inner membrane protease subunit 2 OS=Danio rerio GN=immp2l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1568 Mitochondrial inner membrane protease, subunit IMP2 Cluster-8309.1280 BP_3 2.00 1.44 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08089 Huwentoxin-II family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.12800 BP_3 34.50 1.68 1280 755893212 XP_011295172.1 147 7.5e-07 PREDICTED: uncharacterized protein LOC105262278 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12804 BP_3 1.00 1.62 306 270004332 EFA00780.1 218 1.0e-15 hypothetical protein TcasGA2_TC003666 [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 -- -- -- -- PF09494 Slx4 endonuclease GO:0006260//GO:0006308//GO:0006281 DNA replication//DNA catabolic process//DNA repair GO:0017108 5'-flap endonuclease activity GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex -- -- Cluster-8309.12809 BP_3 3.00 0.58 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12812 BP_3 63.85 1.07 3179 91092914 XP_971430.1 982 2.8e-103 PREDICTED: DNA-directed RNA polymerase III subunit RPC8 [Tribolium castaneum]>gi|642916922|ref|XP_008199556.1| PREDICTED: DNA-directed RNA polymerase III subunit RPC8 [Tribolium castaneum]>gi|270003098|gb|EEZ99545.1| hypothetical protein TcasGA2_TC000127 [Tribolium castaneum] 642916918 XM_008201332.1 244 3.30801e-122 PREDICTED: Tribolium castaneum F-box/LRR-repeat protein 16 (LOC660141), mRNA K03022 RPC8, POLR3H DNA-directed RNA polymerase III subunit RPC8 http://www.genome.jp/dbget-bin/www_bget?ko:K03022 Q9D2C6 719 3.6e-74 DNA-directed RNA polymerase III subunit RPC8 OS=Mus musculus GN=Polr3h PE=2 SV=2 PF13855//PF13516//PF03876//PF00560 Leucine rich repeat//Leucine Rich repeat//SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Leucine Rich Repeat GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0005515//GO:0003899 protein binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3297 DNA-directed RNA polymerase subunit E' Cluster-8309.12815 BP_3 37.80 0.77 2646 642932376 XP_008197087.1 907 1.2e-94 PREDICTED: protein NDNF [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C119 323 2.5e-28 Protein NDNF OS=Mus musculus GN=Ndnf PE=1 SV=2 PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12821 BP_3 361.95 6.45 2995 546677878 ERL88630.1 1340 8.1e-145 hypothetical protein D910_06015, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH20 295 5.0e-25 TATA box-binding protein-associated factor RNA polymerase I subunit B OS=Drosophila melanogaster GN=CG6241 PE=2 SV=1 PF08273//PF00833 Zinc-binding domain of primase-helicase//Ribosomal S17 GO:0006351//GO:0006412//GO:0006269//GO:0042254 transcription, DNA-templated//translation//DNA replication, synthesis of RNA primer//ribosome biogenesis GO:0004386//GO:0003896//GO:0008270//GO:0003735 helicase activity//DNA primase activity//zinc ion binding//structural constituent of ribosome GO:0005657//GO:0005840//GO:0005622//GO:0005730 replication fork//ribosome//intracellular//nucleolus -- -- Cluster-8309.12822 BP_3 31.85 0.55 3073 546677878 ERL88630.1 1303 1.6e-140 hypothetical protein D910_06015, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH20 269 5.3e-22 TATA box-binding protein-associated factor RNA polymerase I subunit B OS=Drosophila melanogaster GN=CG6241 PE=2 SV=1 PF00833//PF08273 Ribosomal S17//Zinc-binding domain of primase-helicase GO:0006412//GO:0006351//GO:0042254//GO:0006269 translation//transcription, DNA-templated//ribosome biogenesis//DNA replication, synthesis of RNA primer GO:0004386//GO:0003896//GO:0003735//GO:0008270 helicase activity//DNA primase activity//structural constituent of ribosome//zinc ion binding GO:0005657//GO:0005730//GO:0005840//GO:0005622 replication fork//nucleolus//ribosome//intracellular -- -- Cluster-8309.12825 BP_3 35.78 0.54 3462 145651804 NP_001078830.1 1482 3.2e-161 inotocin receptor [Tribolium castaneum]>gi|144953865|gb|ABN79656.2| arginine vasopressin receptor [Tribolium castaneum] -- -- -- -- -- K04226 AVPR1A arginine vasopressin receptor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04226 Q7YW31 649 5.1e-66 Cephalotocin receptor 1 OS=Octopus vulgaris GN=CTR1 PE=2 SV=1 PF00001//PF09446 7 transmembrane receptor (rhodopsin family)//VMA21-like domain GO:0007186//GO:0070072//GO:0007187 G-protein coupled receptor signaling pathway//vacuolar proton-transporting V-type ATPase complex assembly//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0005000//GO:0004930 vasopressin receptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.12826 BP_3 233.67 4.07 3058 91080315 XP_974396.1 3037 0.0e+00 PREDICTED: integrator complex subunit 6 [Tribolium castaneum]>gi|270005607|gb|EFA02055.1| hypothetical protein TcasGA2_TC007684 [Tribolium castaneum] 571553425 XM_395179.4 238 6.88491e-119 PREDICTED: Apis mellifera integrator complex subunit 6-like (LOC411711), transcript variant X2, mRNA K13143 INTS6, DDX26 integrator complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13143 Q9UL03 1794 7.7e-199 Integrator complex subunit 6 OS=Homo sapiens GN=INTS6 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3768 DEAD box RNA helicase Cluster-8309.12827 BP_3 29.52 0.31 4929 91080315 XP_974396.1 3268 0.0e+00 PREDICTED: integrator complex subunit 6 [Tribolium castaneum]>gi|270005607|gb|EFA02055.1| hypothetical protein TcasGA2_TC007684 [Tribolium castaneum] 571553425 XM_395179.4 238 1.11475e-118 PREDICTED: Apis mellifera integrator complex subunit 6-like (LOC411711), transcript variant X2, mRNA K13143 INTS6, DDX26 integrator complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13143 Q9UL03 1794 1.2e-198 Integrator complex subunit 6 OS=Homo sapiens GN=INTS6 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3768 DEAD box RNA helicase Cluster-8309.12829 BP_3 6.55 0.42 1041 295291554 ADF87490.1 523 1.5e-50 ferritin 1 [Eriocheir sinensis] 262401250 FJ774807.1 476 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF00210 Ferritin-like domain GO:0006879 cellular iron ion homeostasis GO:0008199 ferric iron binding -- -- -- -- Cluster-8309.1283 BP_3 6.00 0.67 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05715 Piccolo Zn-finger -- -- GO:0046872 metal ion binding GO:0045202 synapse -- -- Cluster-8309.1284 BP_3 2.00 0.33 581 602625904 XP_007419915.1 157 2.3e-08 PREDICTED: LOW QUALITY PROTEIN: actin, cytoplasmic 2 [Python bivittatus] 306922242 AB491092.1 74 1.83215e-28 Sebastes schlegelii mRNA, clone: BRF 46-F8, induced by treatment of LPS K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 Q6S8J3 153 2.8e-09 POTE ankyrin domain family member E OS=Homo sapiens GN=POTEE PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.12840 BP_3 13.97 0.41 1938 861617776 KMQ86664.1 623 7.2e-62 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- Q7JQ07 191 3.7e-13 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12844 BP_3 2.00 0.47 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12601//PF14999 Rubivirus non-structural protein//Shadow of prion protein, neuroprotective GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0003968//GO:0004197//GO:0016817//GO:0017111 RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//nucleoside-triphosphatase activity GO:0031225//GO:0031379 anchored component of membrane//RNA-directed RNA polymerase complex -- -- Cluster-8309.12845 BP_3 4.00 0.81 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12851 BP_3 64.92 3.57 1169 755893212 XP_011295172.1 147 6.8e-07 PREDICTED: uncharacterized protein LOC105262278 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12856 BP_3 61.96 3.58 1127 91087275 XP_975544.1 1040 1.9e-110 PREDICTED: probable complex I intermediate-associated protein 30, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18159 NDUFAF1, CIA30 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18159 Q9VAI1 928 7.4e-99 Complex I intermediate-associated protein 30, mitochondrial OS=Drosophila melanogaster GN=CIA30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2435 Uncharacterized conserved protein Cluster-8309.12860 BP_3 2.00 0.37 555 815897778 XP_012249611.1 150 1.5e-07 PREDICTED: longitudinals lacking protein, isoforms A/B/D/L isoform X4 [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.12870 BP_3 1.00 0.48 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12873 BP_3 1.94 0.35 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12874 BP_3 61.04 0.69 4539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF07776 THAP domain//Zinc-finger associated domain (zf-AD) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.12877 BP_3 79.03 1.09 3784 642913362 XP_008195422.1 235 1.4e-16 PREDICTED: uncharacterized protein LOC103313584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12880 BP_3 11.00 0.44 1504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04452 RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.12885 BP_3 34.31 0.48 3763 642914904 XP_008190437.1 1040 6.2e-110 PREDICTED: aldehyde dehydrogenase 5, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T1L0 282 2.0e-23 Aldehyde dehydrogenase family 16 member A1 OS=Rattus norvegicus GN=Aldh16a1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.12887 BP_3 1.50 2.38 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12888 BP_3 130.25 1.56 4324 642930333 XP_008196351.1 1472 5.8e-160 PREDICTED: protein Wnt-7b [Tribolium castaneum] -- -- -- -- -- K00572 WNT7 wingless-type MMTV integration site family, member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00572 P28465 949 1.0e-100 Protein Wnt-2 OS=Drosophila melanogaster GN=Wnt2 PE=2 SV=2 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.12895 BP_3 12.00 0.41 1691 91087947 XP_972232.1 394 2.3e-35 PREDICTED: uncharacterized protein LOC660945 [Tribolium castaneum]>gi|270011932|gb|EFA08380.1| hypothetical protein TcasGA2_TC006023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08651 DASH complex subunit Duo1 GO:0007067 mitotic nuclear division -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.12896 BP_3 5.50 0.39 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12897 BP_3 26.36 0.33 4173 642921365 XP_972788.2 3503 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 2.17432e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1297 4.5e-141 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF00097//PF00787//PF12861//PF12678//PF13639 Zinc finger, C3HC4 type (RING finger)//PX domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Ring finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0035091//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//phosphatidylinositol binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.12899 BP_3 5.00 0.37 942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.129 BP_3 1.00 0.35 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1290 BP_3 20.00 3.00 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12900 BP_3 30.00 6.04 531 391335054 XP_003741912.1 472 6.4e-45 PREDICTED: 40S ribosomal protein S26-like [Metaseiulus occidentalis] 194758718 XM_001961573.1 69 1.00188e-25 Drosophila ananassae GF14848 (Dana\GF14848), mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 P62856 460 6.5e-45 40S ribosomal protein S26 OS=Rattus norvegicus GN=Rps26 PE=3 SV=3 PF01922//PF01283 SRP19 protein//Ribosomal protein S26e GO:0006614//GO:0006412//GO:0042254 SRP-dependent cotranslational protein targeting to membrane//translation//ribosome biogenesis GO:0003735//GO:0008312 structural constituent of ribosome//7S RNA binding GO:0048500//GO:0005622//GO:0005840 signal recognition particle//intracellular//ribosome KOG1768 40s ribosomal protein S26 Cluster-8309.12901 BP_3 1.00 0.43 402 -- -- -- -- -- 728050539 CP009888.1 318 2.83978e-164 Pseudoalteromonas sp. OCN003 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12903 BP_3 16.00 0.64 1489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12904 BP_3 5.00 0.71 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12910 BP_3 15.60 0.52 1733 642939503 XP_008190892.1 744 6.0e-76 PREDICTED: protein shifted isoform X1 [Tribolium castaneum]>gi|642939505|ref|XP_008190898.1| PREDICTED: protein shifted isoform X1 [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 435 1.7e-41 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008//PF09064 EGF-like domain//Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0005515//GO:0004888 protein binding//transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.12913 BP_3 7.00 1.12 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12915 BP_3 6.00 1.27 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12916 BP_3 5.74 1.03 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12919 BP_3 5.26 0.91 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12922 BP_3 22.00 1.35 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11382//PF06156//PF07851//PF04111//PF07544 Copper transport outer membrane protein, MctB//Protein of unknown function (DUF972)//TMPIT-like protein//Autophagy protein Apg6//RNA polymerase II transcription mediator complex subunit 9 GO:0006914//GO:0006810//GO:0006357//GO:0006260 autophagy//transport//regulation of transcription from RNA polymerase II promoter//DNA replication GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0016021 mediator complex//integral component of membrane -- -- Cluster-8309.12925 BP_3 1.00 0.43 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12927 BP_3 3.00 1.80 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12929 BP_3 246.32 12.80 1219 189237437 XP_001815618.1 867 2.3e-90 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWP5 346 2.5e-31 Alpha-tocopherol transfer protein OS=Mus musculus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12931 BP_3 133.00 3.42 2167 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12934 BP_3 109.45 1.26 4473 642915646 XP_008190694.1 3010 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 6.8e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.12936 BP_3 13.69 1.15 864 642928877 XP_970196.2 550 9.4e-54 PREDICTED: transmembrane protein 68 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VCR6 353 2.7e-32 Transmembrane protein 68 OS=Bos taurus GN=TMEM68 PE=2 SV=1 PF01553//PF03982 Acyltransferase//Diacylglycerol acyltransferase GO:0008152 metabolic process GO:0016747//GO:0016746 transferase activity, transferring acyl groups other than amino-acyl groups//transferase activity, transferring acyl groups -- -- KOG4321 Predicted phosphate acyltransferases Cluster-8309.12937 BP_3 275.31 12.98 1314 642928877 XP_970196.2 1219 3.8e-131 PREDICTED: transmembrane protein 68 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VCR6 750 3.8e-78 Transmembrane protein 68 OS=Bos taurus GN=TMEM68 PE=2 SV=1 PF03982//PF01553 Diacylglycerol acyltransferase//Acyltransferase GO:0008152 metabolic process GO:0016747//GO:0016746 transferase activity, transferring acyl groups other than amino-acyl groups//transferase activity, transferring acyl groups -- -- KOG4321 Predicted phosphate acyltransferases Cluster-8309.12942 BP_3 51.00 0.59 4472 91087963 XP_972974.1 4227 0.0e+00 PREDICTED: uncharacterized protein LOC661735 [Tribolium castaneum] 768435341 XM_011560813.1 401 0 PREDICTED: Plutella xylostella uncharacterized LOC105389662 (LOC105389662), mRNA -- -- -- -- Q8JI28 181 1.2e-11 Tolloid-like protein 1 OS=Xenopus laevis GN=tll1 PE=1 SV=1 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) GO:0015992//GO:0006120//GO:0006744//GO:0042773//GO:0006814 proton transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//ATP synthesis coupled electron transport//sodium ion transport GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.12944 BP_3 7.13 0.78 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12946 BP_3 218.96 4.17 2820 270010355 EFA06803.1 1242 1.8e-133 hypothetical protein TcasGA2_TC009742 [Tribolium castaneum] -- -- -- -- -- K11268 ESCO, ECO1 N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11268 Q8CIB9 441 5.5e-42 N-acetyltransferase ESCO2 OS=Mus musculus GN=Esco2 PE=2 SV=3 PF00583//PF13508 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3014 Protein involved in establishing cohesion between sister chromatids during DNA replication Cluster-8309.12947 BP_3 8.00 0.42 1215 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12949 BP_3 1.00 5.92 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12950 BP_3 6.00 0.88 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12951 BP_3 19.00 0.77 1476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12954 BP_3 5.00 0.53 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12956 BP_3 33.70 1.93 1135 642924004 XP_008193965.1 762 3.2e-78 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 343 5.1e-31 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF00400//PF03275 WD domain, G-beta repeat//UDP-galactopyranose mutase -- -- GO:0005515//GO:0008767 protein binding//UDP-galactopyranose mutase activity -- -- KOG1188 WD40 repeat protein Cluster-8309.12958 BP_3 3.00 1.00 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12964 BP_3 194.88 21.48 729 642915577 XP_008190672.1 392 1.7e-35 PREDICTED: 39S ribosomal protein L52, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17433 MRPL52 large subunit ribosomal protein L52 http://www.genome.jp/dbget-bin/www_bget?ko:K17433 Q7JWG9 318 2.6e-28 39S ribosomal protein L52, mitochondrial OS=Drosophila melanogaster GN=mRpL52 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12969 BP_3 2.00 1.56 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12971 BP_3 103.47 5.67 1172 751473872 XP_011192306.1 410 2.2e-37 PREDICTED: caspase [Bactrocera cucurbitae] -- -- -- -- -- K04396 CASP6 caspase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K04396 P89116 395 4.9e-37 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.12972 BP_3 1.00 13.22 236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12974 BP_3 37.34 0.69 2908 189234553 XP_973928.2 900 8.2e-94 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V9A8 291 1.4e-24 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 PF00126 Bacterial regulatory helix-turn-helix protein, lysR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.12976 BP_3 46.81 2.79 1101 795012426 XP_011878089.1 231 1.2e-16 PREDICTED: uncharacterized protein LOC105567651, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02072 Prepro-orexin GO:0007218//GO:0007631 neuropeptide signaling pathway//feeding behavior -- -- -- -- -- -- Cluster-8309.12978 BP_3 23.00 0.98 1420 642927156 XP_008195160.1 905 1.1e-94 PREDICTED: homeobox protein Hox-D4a [Tribolium castaneum]>gi|270010104|gb|EFA06552.1| hypothetical protein TcasGA2_TC009461 [Tribolium castaneum] 751798033 XM_011210610.1 57 1.30778e-18 PREDICTED: Bactrocera dorsalis uncharacterized LOC105230041 (LOC105230041), mRNA K08025 HLXB9, HB9 homeobox protein HB9 http://www.genome.jp/dbget-bin/www_bget?ko:K08025 Q9QZW9 350 9.9e-32 Motor neuron and pancreas homeobox protein 1 OS=Mus musculus GN=Mnx1 PE=2 SV=2 PF08880//PF00046 QLQ//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005524 DNA binding//ATP binding GO:0005634 nucleus KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.12982 BP_3 3.00 1.32 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12986 BP_3 292.45 22.05 931 189237096 XP_970660.2 945 1.6e-99 PREDICTED: peroxiredoxin-6 [Tribolium castaneum]>gi|270008182|gb|EFA04630.1| hypothetical protein TcasGA2_TC013791 [Tribolium castaneum] 572267954 XM_006611975.1 63 3.91411e-22 PREDICTED: Apis dorsata peroxiredoxin-6-like (LOC102672292), mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 Q5ZJF4 731 4.3e-76 Peroxiredoxin-6 OS=Gallus gallus GN=PRDX6 PE=2 SV=3 PF08534//PF00578//PF10417 Redoxin//AhpC/TSA family//C-terminal domain of 1-Cys peroxiredoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0051920//GO:0016491 antioxidant activity//peroxiredoxin activity//oxidoreductase activity -- -- KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.12987 BP_3 4.00 0.35 840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12988 BP_3 5.00 0.49 787 642931385 XP_008196557.1 178 1.2e-10 PREDICTED: zinc finger protein 827-like isoform X2 [Tribolium castaneum]>gi|270012149|gb|EFA08597.1| hypothetical protein TcasGA2_TC006256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 150 8.5e-09 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF07776//PF02150//PF04988//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//RNA polymerases M/15 Kd subunit//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003677//GO:0003899 zinc ion binding//metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.12991 BP_3 68.34 1.36 2707 642937652 XP_966876.3 431 1.9e-39 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 299 1.5e-25 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF07776//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.12992 BP_3 35.29 1.04 1922 642937652 XP_966876.3 429 2.2e-39 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NTW7 295 3.2e-25 Zinc finger protein 64 homolog, isoforms 3 and 4 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF07776//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.12993 BP_3 152.00 6.35 1446 478259670 ENN79514.1 1579 7.5e-173 hypothetical protein YQE_03977, partial [Dendroctonus ponderosae]>gi|546682940|gb|ERL92819.1| hypothetical protein D910_10127 [Dendroctonus ponderosae] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q7JZB4 1484 3.2e-163 Mannose-1-phosphate guanyltransferase beta OS=Drosophila melanogaster GN=CG1129 PE=2 SV=1 PF07959//PF00483//PF01128 L-fucokinase//Nucleotidyl transferase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299//GO:0009058//GO:0006694 isoprenoid biosynthetic process//biosynthetic process//steroid biosynthetic process GO:0050518//GO:0016779//GO:0016772 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.12998 BP_3 3024.38 182.16 1092 546678229 ERL88905.1 201 3.5e-13 hypothetical protein D910_06287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11081 Protein of unknown function (DUF2890) GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.13 BP_3 1.44 0.38 476 149287004 ABR23401.1 355 2.1e-31 40S ribosomal protein S10 [Ornithodoros parkeri] 697083934 XM_009656731.1 455 0 Verticillium dahliae VdLs.17 40S ribosomal protein S10-A mRNA K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 Q08745 386 2.2e-36 40S ribosomal protein S10-A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPS10A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3344 40s ribosomal protein s10 Cluster-8309.13001 BP_3 39.00 0.57 3582 642913282 XP_008201469.1 2528 1.7e-282 PREDICTED: LOW QUALITY PROTEIN: high-affinity choline transporter 1 [Tribolium castaneum] 571538879 XM_392464.5 288 1.29567e-146 PREDICTED: Apis mellifera high-affinity choline transporter 1 (LOC408935), mRNA K14387 SLC5A7, CHT1 solute carrier family 5 (high affinity choline transporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14387 Q9VE46 2315 3.5e-259 High-affinity choline transporter 1 OS=Drosophila melanogaster GN=CG7708 PE=2 SV=2 PF00474//PF05151 Sodium:solute symporter family//Photosystem II reaction centre M protein (PsbM) GO:0019684//GO:0006810//GO:0055085//GO:0015979 photosynthesis, light reaction//transport//transmembrane transport//photosynthesis GO:0005215 transporter activity GO:0009523//GO:0016020//GO:0016021 photosystem II//membrane//integral component of membrane KOG3761 Choline transporter Cluster-8309.13003 BP_3 72.83 0.72 5193 642922636 XP_971090.3 2313 2.1e-257 PREDICTED: uncharacterized protein LOC659719 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 Q6P7W0 366 5.0e-33 Sentrin-specific protease 6 OS=Mus musculus GN=Senp6 PE=2 SV=3 PF02944//PF02902 BESS motif//Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0003677//GO:0008234 DNA binding//cysteine-type peptidase activity -- -- KOG0779 Protease, Ulp1 family Cluster-8309.13010 BP_3 76.21 0.66 5824 642931886 XP_008196768.1 1840 1.7e-202 PREDICTED: meiosis arrest female protein 1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K17573 LKAP, MARF1 meiosis arrest female protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17573 B2GUN4 812 1.1e-84 Meiosis arrest female protein 1 homolog OS=Xenopus tropicalis GN=marf1 PE=2 SV=1 PF00076//PF00106 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//short chain dehydrogenase GO:0008152 metabolic process GO:0003676//GO:0016491 nucleic acid binding//oxidoreductase activity -- -- -- -- Cluster-8309.13016 BP_3 19.00 0.42 2476 478250478 ENN70973.1 954 3.8e-100 hypothetical protein YQE_12373, partial [Dendroctonus ponderosae] -- -- -- -- -- K16745 B9D2 B9 domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16745 Q6DGZ1 379 7.5e-35 B9 domain-containing protein 2 OS=Danio rerio GN=b9d2 PE=2 SV=1 PF00705 Proliferating cell nuclear antigen, N-terminal domain GO:0006275 regulation of DNA replication GO:0003677 DNA binding -- -- KOG4028 Uncharacterized conserved protein Cluster-8309.13019 BP_3 6.51 1.55 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13020 BP_3 5.00 0.52 759 -- -- -- -- -- 118789175 XM_001237901.1 34 4.18013e-06 Anopheles gambiae str. PEST AGAP008214-PA (AgaP_AGAP008214) mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13032 BP_3 3.00 0.81 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13034 BP_3 5.00 3.03 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13036 BP_3 1.00 1.89 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13037 BP_3 3.00 0.66 510 478258161 ENN78299.1 223 4.6e-16 hypothetical protein YQE_05449, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13039 BP_3 20.16 0.80 1499 478251633 ENN72090.1 307 2.5e-25 hypothetical protein YQE_11257, partial [Dendroctonus ponderosae]>gi|546674556|gb|ERL85912.1| hypothetical protein D910_03327 [Dendroctonus ponderosae] -- -- -- -- -- K06875 PDCD5, TFAR19 programmed cell death protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06875 Q93408 174 2.7e-11 Uncharacterized protein D2005.3 OS=Caenorhabditis elegans GN=D2005.3 PE=3 SV=2 PF01984 Double-stranded DNA-binding domain -- -- GO:0003677 DNA binding -- -- KOG3431 Apoptosis-related protein/predicted DNA-binding protein Cluster-8309.13040 BP_3 1.00 0.83 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13041 BP_3 261.16 3.82 3586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08563//PF11705 P53 transactivation motif//DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter GO:0005515 protein binding -- -- -- -- Cluster-8309.13042 BP_3 36.83 0.86 2367 546683702 ERL93480.1 1666 1.0e-182 hypothetical protein D910_10770 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1103 8.0e-119 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00735//PF03193//PF00005//PF01926//PF06414//PF13304//PF00664 Septin//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016301//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.13048 BP_3 2.00 2.80 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13053 BP_3 896.90 19.60 2497 546685168 ERL94695.1 216 1.5e-14 hypothetical protein D910_11970 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09334 tRNA synthetases class I (M) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- -- -- Cluster-8309.13061 BP_3 63.00 9.85 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13064 BP_3 16.02 1.14 968 478250258 ENN70758.1 214 9.6e-15 hypothetical protein YQE_12547, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13066 BP_3 2.82 0.43 604 546678332 ERL88974.1 449 3.4e-42 hypothetical protein D910_06352, partial [Dendroctonus ponderosae] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 402 3.9e-38 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF00156 Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process -- -- -- -- KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.13071 BP_3 617.66 10.55 3114 270016355 EFA12801.1 1835 3.4e-202 hypothetical protein TcasGA2_TC001864 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13072 BP_3 85.06 1.15 3859 642930094 XP_008196249.1 811 2.3e-83 PREDICTED: uncharacterized protein LOC655867 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095//PF12740//PF02822 WAP-type (Whey Acidic Protein) 'four-disulfide core'//Chlorophyllase enzyme//Antistasin family GO:0015994//GO:0015996 chlorophyll metabolic process//chlorophyll catabolic process GO:0047746//GO:0030414//GO:0004867 chlorophyllase activity//peptidase inhibitor activity//serine-type endopeptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.13073 BP_3 2.38 0.37 606 189233864 XP_972774.2 251 3.1e-19 PREDICTED: LIM and calponin homology domains-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270014752|gb|EFA11200.1| hypothetical protein TcasGA2_TC005164 [Tribolium castaneum] 642911269 XM_967681.3 143 8.42328e-67 PREDICTED: Tribolium castaneum LIM and calponin homology domains-containing protein 1 (LOC661528), transcript variant X1, mRNA -- -- -- -- Q0KIC3 161 3.5e-10 Uncharacterized protein CG43427 OS=Drosophila melanogaster GN=CG43427 PE=2 SV=1 PF03938//PF09110//PF02096//PF10186 Outer membrane protein (OmpH-like)//HAND//60Kd inner membrane protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508//GO:0051205//GO:0043044 positive regulation of autophagy//protein insertion into membrane//ATP-dependent chromatin remodeling GO:0031491//GO:0051082 nucleosome binding//unfolded protein binding GO:0016021//GO:0000785 integral component of membrane//chromatin -- -- Cluster-8309.13074 BP_3 1.00 0.76 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13075 BP_3 79.05 5.13 1034 546684870 ERL94452.1 181 6.9e-11 hypothetical protein D910_11729 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13080 BP_3 10.00 0.48 1296 501291667 BAN20387.1 730 1.9e-74 calponin/transgelin [Riptortus pedestris] 241691756 XM_002401975.1 80 1.95061e-31 Ixodes scapularis calponin, putative, mRNA -- -- -- -- Q24799 370 4.3e-34 Myophilin OS=Echinococcus granulosus PE=2 SV=1 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.13081 BP_3 41.10 1.17 1987 478250007 ENN70513.1 662 2.2e-66 hypothetical protein YQE_12689, partial [Dendroctonus ponderosae] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q6DI51 287 2.8e-24 Nucleoside diphosphate kinase 6 OS=Danio rerio GN=nme6 PE=2 SV=1 PF00334 Nucleoside diphosphate kinase GO:0006144//GO:0006228//GO:0006183//GO:0006206//GO:0006241//GO:0006165 purine nucleobase metabolic process//UTP biosynthetic process//GTP biosynthetic process//pyrimidine nucleobase metabolic process//CTP biosynthetic process//nucleoside diphosphate phosphorylation GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.13083 BP_3 34.00 0.95 2025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05920 Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.13086 BP_3 10.13 0.55 1187 546680629 ERL90867.1 1258 1.0e-135 hypothetical protein D910_08212 [Dendroctonus ponderosae] -- -- -- -- -- K11418 HDAC11 histone deacetylase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11418 Q9GKU5 991 3.9e-106 Histone deacetylase 11 OS=Macaca fascicularis GN=HDAC11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1344 Predicted histone deacetylase Cluster-8309.13088 BP_3 20.00 0.84 1442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08515 Transforming growth factor beta type I GS-motif GO:0007178//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004675//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.13089 BP_3 16.00 0.94 1109 270010513 EFA06961.1 532 1.5e-51 hypothetical protein TcasGA2_TC009919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2TBG7 367 8.2e-34 Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Bos taurus GN=ISCA2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1119 Mitochondrial Fe-S cluster biosynthesis protein ISA2 (contains a HesB-like domain) Cluster-8309.1309 BP_3 9.00 0.83 814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13094 BP_3 62.66 2.88 1342 136223 P05547.1 583 2.2e-57 RecName: Full=Troponin I; Short=TnI [Pontastacus leptodactylus]>gi|102756|pir||A31484 troponin I, fast skeletal muscle - broad-fingered crayfish 414448055 JX683730.1 408 0 Litopenaeus vannamei clone TPNi3 troponin I mRNA, complete cds -- -- -- -- P05547 583 9.0e-59 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF03776//PF00992//PF05190 Septum formation topological specificity factor MinE//Troponin//MutS family domain IV GO:0051301//GO:0006298//GO:0032955 cell division//mismatch repair//regulation of barrier septum assembly GO:0030983//GO:0005524 mismatched DNA binding//ATP binding GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.13095 BP_3 11.26 0.53 1318 136223 P05547.1 583 2.1e-57 RecName: Full=Troponin I; Short=TnI [Pontastacus leptodactylus]>gi|102756|pir||A31484 troponin I, fast skeletal muscle - broad-fingered crayfish 414448075 JX683731.1 372 0 Litopenaeus vannamei clone TPNi4 troponin I mRNA, complete cds -- -- -- -- P05547 583 8.8e-59 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992//PF03776//PF05190 Troponin//Septum formation topological specificity factor MinE//MutS family domain IV GO:0051301//GO:0006298//GO:0032955 cell division//mismatch repair//regulation of barrier septum assembly GO:0030983//GO:0005524 mismatched DNA binding//ATP binding GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.13096 BP_3 6.00 0.68 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13097 BP_3 279.71 6.00 2540 642934881 XP_966430.2 1844 2.5e-203 PREDICTED: DDB1- and CUL4-associated factor 7 isoform X1 [Tribolium castaneum] 662195262 XM_008472391.1 245 7.33279e-123 PREDICTED: Diaphorina citri DDB1- and CUL4-associated factor 7 (LOC103507876), mRNA K11805 WDR68, HAN11 WD repeat-containing protein 68 http://www.genome.jp/dbget-bin/www_bget?ko:K11805 P61963 1651 2.4e-182 DDB1- and CUL4-associated factor 7 OS=Mus musculus GN=Dcaf7 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0290 Conserved WD40 repeat-containing protein AN11 Cluster-8309.1310 BP_3 50.36 0.55 4699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13100 BP_3 126.05 5.76 1347 646709072 KDR15120.1 596 6.8e-59 hypothetical protein L798_11003 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12919 TcdA/TcdB catalytic glycosyltransferase domain -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.13105 BP_3 285.48 2.97 4932 642913527 XP_008201051.1 3291 0.0e+00 PREDICTED: protein timeless homolog [Tribolium castaneum]>gi|270002773|gb|EEZ99220.1| timeout [Tribolium castaneum] -- -- -- -- -- K03155 TIMELESS timeless http://www.genome.jp/dbget-bin/www_bget?ko:K03155 Q9UNS1 1789 4.7e-198 Protein timeless homolog OS=Homo sapiens GN=TIMELESS PE=1 SV=2 PF04211 Tetrahydromethanopterin S-methyltransferase, subunit C GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane KOG1974 DNA topoisomerase I-interacting protein Cluster-8309.13109 BP_3 5.00 0.96 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13110 BP_3 29.08 1.04 1645 642929186 XP_008195727.1 576 1.7e-56 PREDICTED: putative gamma-glutamylcyclotransferase CG2811 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y2 355 3.0e-32 Putative gamma-glutamylcyclotransferase CG2811 OS=Drosophila melanogaster GN=CG2811 PE=2 SV=2 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- KOG4450 Uncharacterized conserved protein Cluster-8309.13112 BP_3 19.47 0.34 3055 642933135 XP_973578.2 1649 1.2e-180 PREDICTED: DNA topoisomerase 3-alpha [Tribolium castaneum] -- -- -- -- -- K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 Q9NG98 795 5.3e-83 DNA topoisomerase 3-alpha OS=Drosophila melanogaster GN=Top3alpha PE=2 SV=2 PF06839//PF16588//PF01131//PF00556//PF01396 GRF zinc finger//C2H2 zinc-finger//DNA topoisomerase//Antenna complex alpha/beta subunit//Topoisomerase DNA binding C4 zinc finger GO:0019684//GO:0006265//GO:0006118 photosynthesis, light reaction//DNA topological change//obsolete electron transport GO:0008270//GO:0003676//GO:0003916//GO:0045156//GO:0003677 zinc ion binding//nucleic acid binding//DNA topoisomerase activity//electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//DNA binding GO:0005694//GO:0030077//GO:0016021 chromosome//plasma membrane light-harvesting complex//integral component of membrane KOG1956 DNA topoisomerase III alpha Cluster-8309.13114 BP_3 73.27 10.32 634 270014574 EFA11022.1 289 1.3e-23 hypothetical protein TcasGA2_TC004610 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13116 BP_3 169.00 6.08 1632 642913056 XP_008201369.1 1397 1.1e-151 PREDICTED: anosmin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23352 500 4.6e-49 Anosmin-1 OS=Homo sapiens GN=KAL1 PE=1 SV=3 PF16656//PF00041//PF00095 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//WAP-type (Whey Acidic Protein) 'four-disulfide core' GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0030414//GO:0005515//GO:0046872 acid phosphatase activity//peptidase inhibitor activity//protein binding//metal ion binding GO:0005576 extracellular region KOG4802 Adhesion-type protein Cluster-8309.13119 BP_3 538.01 19.60 1615 642929319 XP_008195785.1 1373 6.5e-149 PREDICTED: stomatin-like protein 2, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UJZ1 1028 2.7e-110 Stomatin-like protein 2, mitochondrial OS=Homo sapiens GN=STOML2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2620 Prohibitins and stomatins of the PID superfamily Cluster-8309.13120 BP_3 10.00 0.55 1173 -- -- -- -- -- 697067330 XM_009650555.1 748 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF14991//PF00974//PF11770 Protein melan-A//Rhabdovirus spike glycoprotein//GRB2-binding adapter (GAPT) -- -- -- -- GO:0016021//GO:0042470//GO:0019031 integral component of membrane//melanosome//viral envelope -- -- Cluster-8309.13126 BP_3 181.00 4.40 2276 260782407 XP_002586279.1 599 5.1e-59 hypothetical protein BRAFLDRAFT_132313 [Branchiostoma floridae]>gi|229271379|gb|EEN42290.1| hypothetical protein BRAFLDRAFT_132313 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q8N4W9 566 1.4e-56 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF16622//PF13912//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.13129 BP_3 2.00 0.81 409 815768980 XP_012234128.1 360 4.8e-32 PREDICTED: uncharacterized protein LOC105678962 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13132 BP_3 6.00 0.34 1147 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13140 BP_3 7.61 0.36 1300 642919377 XP_008191846.1 339 4.1e-29 PREDICTED: vascular endothelial growth factor receptor 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13147 BP_3 6.38 0.66 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1315 BP_3 1.00 1.25 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13152 BP_3 11.86 1.17 782 642924977 XP_008194123.1 213 1.0e-14 PREDICTED: myosin-6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13153 BP_3 153.26 2.41 3351 642924977 XP_008194123.1 501 1.8e-47 PREDICTED: myosin-6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305//PF04559//PF03233//PF14822//PF07851//PF04977//PF03623//PF00866//PF08919//PF07716//PF01025//PF06220//PF04111//PF03462//PF00170//PF06005 Protein of unknown function (DUF1049)//Herpesvirus UL17 protein//Aphid transmission protein//Vasohibin//TMPIT-like protein//Septum formation initiator//Focal adhesion targeting region//Ring hydroxylating beta subunit//F-actin binding//Basic region leucine zipper//GrpE//U1 zinc finger//Autophagy protein Apg6//PCRF domain//bZIP transcription factor//Protein of unknown function (DUF904) GO:0006415//GO:0055114//GO:0006725//GO:0007172//GO:0019089//GO:0006355//GO:0045765//GO:0006323//GO:0007049//GO:0007165//GO:0006914//GO:0006468//GO:0043093//GO:0000917//GO:0006449//GO:0006457 translational termination//oxidation-reduction process//cellular aromatic compound metabolic process//signal complex assembly//transmission of virus//regulation of transcription, DNA-templated//regulation of angiogenesis//DNA packaging//cell cycle//signal transduction//autophagy//protein phosphorylation//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of translational termination//protein folding GO:0051087//GO:0003700//GO:0005524//GO:0008270//GO:0043565//GO:0000774//GO:0042803//GO:0004871//GO:0003824//GO:0004713//GO:0004715//GO:0016149 chaperone binding//transcription factor activity, sequence-specific DNA binding//ATP binding//zinc ion binding//sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//protein homodimerization activity//signal transducer activity//catalytic activity//protein tyrosine kinase activity//non-membrane spanning protein tyrosine kinase activity//translation release factor activity, codon specific GO:0018444//GO:0005925//GO:0005667//GO:0005840//GO:0005737//GO:0016021//GO:0005887//GO:0019012 translation release factor complex//focal adhesion//transcription factor complex//ribosome//cytoplasm//integral component of membrane//integral component of plasma membrane//virion -- -- Cluster-8309.13158 BP_3 57.70 0.71 4220 642913975 XP_008201498.1 2845 0.0e+00 PREDICTED: nicotinic acetylcholine receptor alpha4 subunit isoform X1 [Tribolium castaneum] 817213541 XM_012427580.1 503 0 PREDICTED: Orussus abietinus acetylcholine receptor subunit alpha-like (LOC105701135), transcript variant X2, mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P91766 1859 3.1e-206 Acetylcholine receptor subunit alpha-like OS=Manduca sexta GN=ARA1 PE=2 SV=1 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.1316 BP_3 2.00 0.57 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13163 BP_3 61.75 0.61 5206 91084487 XP_971744.1 636 6.0e-63 PREDICTED: equilibrative nucleoside transporter 3 [Tribolium castaneum]>gi|270008874|gb|EFA05322.1| hypothetical protein TcasGA2_TC015480 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1A4N1 442 7.8e-42 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF13965//PF01733 dsRNA-gated channel SID-1//Nucleoside transporter GO:0015858//GO:0015931//GO:0033227//GO:0006810 nucleoside transport//nucleobase-containing compound transport//dsRNA transport//transport GO:0051033//GO:0005337 RNA transmembrane transporter activity//nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.13164 BP_3 7.00 0.90 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13165 BP_3 7.00 0.46 1020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13166 BP_3 3.42 0.33 793 189237572 XP_974818.2 288 2.1e-23 PREDICTED: uncharacterized protein LOC663689 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13169 BP_3 23.00 0.31 3909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13173 BP_3 16.63 0.44 2126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13175 BP_3 9.00 1.30 626 196013755 XP_002116738.1 154 5.6e-08 hypothetical protein TRIADDRAFT_31339 [Trichoplax adhaerens]>gi|190580716|gb|EDV20797.1| hypothetical protein TRIADDRAFT_31339 [Trichoplax adhaerens] -- -- -- -- -- -- -- -- -- P12785 131 1.1e-06 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- GO:0006633//GO:0042967 fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0016788//GO:0004312 hydrolase activity, acting on ester bonds//fatty acid synthase activity GO:0005835 fatty acid synthase complex -- -- Cluster-8309.13178 BP_3 5.00 1.77 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13180 BP_3 13.09 2.62 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13181 BP_3 19.10 0.72 1568 546686115 ERL95507.1 275 1.3e-21 hypothetical protein D910_12769 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W0Y6 156 3.4e-09 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF01747 ATP-sulfurylase GO:0006790//GO:0006144 sulfur compound metabolic process//purine nucleobase metabolic process GO:0004781 sulfate adenylyltransferase (ATP) activity -- -- -- -- Cluster-8309.13185 BP_3 29.68 0.86 1950 91089225 XP_968001.1 302 1.2e-24 PREDICTED: PRKR-interacting protein 1 homolog [Tribolium castaneum]>gi|270011471|gb|EFA07919.1| hypothetical protein TcasGA2_TC005495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNG8 210 2.3e-15 PRKR-interacting protein 1 homolog OS=Xenopus laevis GN=prkrip1 PE=2 SV=1 PF04999//PF02862//PF14943 Cell division protein FtsL//DDHD domain//Mitochondrial ribosome subunit S26 GO:0007049//GO:0051301 cell cycle//cell division GO:0046872 metal ion binding GO:0005763//GO:0016021 mitochondrial small ribosomal subunit//integral component of membrane KOG4055 Uncharacterized conserved protein Cluster-8309.13187 BP_3 18.22 0.49 2072 91089225 XP_968001.1 302 1.3e-24 PREDICTED: PRKR-interacting protein 1 homolog [Tribolium castaneum]>gi|270011471|gb|EFA07919.1| hypothetical protein TcasGA2_TC005495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNG8 210 2.5e-15 PRKR-interacting protein 1 homolog OS=Xenopus laevis GN=prkrip1 PE=2 SV=1 PF14943//PF02862//PF04999 Mitochondrial ribosome subunit S26//DDHD domain//Cell division protein FtsL GO:0051301//GO:0007049 cell division//cell cycle GO:0046872 metal ion binding GO:0016021//GO:0005763 integral component of membrane//mitochondrial small ribosomal subunit KOG4055 Uncharacterized conserved protein Cluster-8309.1319 BP_3 60.00 4.70 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13195 BP_3 19.73 0.89 1355 675369149 KFM62051.1 1655 1.1e-181 Eukaryotic initiation factor 4A-II, partial [Stegodyphus mimosarum] 110339424 DQ667140.1 1217 0 Callinectes sapidus eukaryotic initiation factor 4A mRNA, complete cds K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 P10630 1624 1.8e-179 Eukaryotic initiation factor 4A-II OS=Mus musculus GN=Eif4a2 PE=2 SV=2 PF04851//PF00579//PF00270//PF07652 Type III restriction enzyme, res subunit//tRNA synthetases class I (W and Y)//DEAD/DEAH box helicase//Flavivirus DEAD domain GO:0006418//GO:0019079 tRNA aminoacylation for protein translation//viral genome replication GO:0004812//GO:0003676//GO:0000166//GO:0008026//GO:0016787//GO:0003677//GO:0005524 aminoacyl-tRNA ligase activity//nucleic acid binding//nucleotide binding//ATP-dependent helicase activity//hydrolase activity//DNA binding//ATP binding -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.13198 BP_3 4.49 0.35 915 642920718 XP_008192534.1 265 1.1e-20 PREDICTED: LYR motif-containing protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXA0 209 1.4e-15 LYR motif-containing protein 5 OS=Taeniopygia guttata GN=LYRM5 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.132 BP_3 100.00 31.76 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13203 BP_3 113.95 4.15 1615 332373040 AEE61661.1 1714 1.9e-188 unknown [Dendroctonus ponderosae]>gi|478250242|gb|ENN70742.1| hypothetical protein YQE_12531, partial [Dendroctonus ponderosae]>gi|546685939|gb|ERL95353.1| hypothetical protein D910_12618 [Dendroctonus ponderosae] -- -- -- -- -- K03142 TFIIH2, GTF2H2, SSL1 transcription initiation factor TFIIH subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03142 Q2TBV5 1122 3.4e-121 General transcription factor IIH subunit 2 OS=Bos taurus GN=GTF2H2 PE=2 SV=1 PF07975//PF07649//PF01363 TFIIH C1-like domain//C1-like domain//FYVE zinc finger GO:0055114//GO:0006281 oxidation-reduction process//DNA repair GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 Cluster-8309.13205 BP_3 643.97 8.35 4008 91079786 XP_967971.1 1583 7.2e-173 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 8.7e-126 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607 Chitin binding Peritrophin-A domain GO:0042254//GO:0006396//GO:0006030 ribosome biogenesis//RNA processing//chitin metabolic process GO:0008061//GO:0003824 chitin binding//catalytic activity GO:0005730//GO:0005576 nucleolus//extracellular region KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.13208 BP_3 38.06 0.60 3372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1321 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13216 BP_3 170.27 4.51 2112 91087145 XP_975296.1 816 3.3e-84 PREDICTED: ATP-dependent DNA helicase 2 subunit 1 [Tribolium castaneum]>gi|270011089|gb|EFA07537.1| inverted repeat-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02735 Ku70/Ku80 beta-barrel domain GO:0006303 double-strand break repair via nonhomologous end joining GO:0003677 DNA binding -- -- -- -- Cluster-8309.13218 BP_3 293.73 9.36 1805 91087145 XP_975296.1 816 2.8e-84 PREDICTED: ATP-dependent DNA helicase 2 subunit 1 [Tribolium castaneum]>gi|270011089|gb|EFA07537.1| inverted repeat-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02735 Ku70/Ku80 beta-barrel domain GO:0006303 double-strand break repair via nonhomologous end joining GO:0003677 DNA binding -- -- -- -- Cluster-8309.13221 BP_3 44.44 0.52 4435 642912669 XP_008200957.1 3101 0.0e+00 PREDICTED: aminopeptidase N [Tribolium castaneum] 556957556 XM_005989784.1 42 9.05226e-10 PREDICTED: Latimeria chalumnae alanyl (membrane) aminopeptidase (ANPEP), transcript variant X3, mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1497 3.1e-164 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.13223 BP_3 76.24 0.84 4651 817085348 XP_012265360.1 465 3.6e-43 PREDICTED: tubulin beta chain-like [Athalia rosae] 676386942 XM_009038502.1 161 6.69637e-76 Aureococcus anophagefferens tubulin beta chain partial mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 P08841 422 1.4e-39 Tubulin beta-3 chain OS=Drosophila melanogaster GN=betaTub60D PE=2 SV=2 PF00091//PF02944 Tubulin/FtsZ family, GTPase domain//BESS motif -- -- GO:0003924//GO:0003677 GTPase activity//DNA binding -- -- KOG1375 Beta tubulin Cluster-8309.13226 BP_3 25.01 1.08 1408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13227 BP_3 42.00 1.84 1390 642914132 XP_008201558.1 589 4.5e-58 PREDICTED: uncharacterized protein C19orf52 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BSF4 201 1.8e-14 Uncharacterized protein C19orf52 OS=Homo sapiens GN=C19orf52 PE=1 SV=2 PF05373//PF02740 L-proline 3-hydroxylase, C-terminal//Colipase, C-terminal domain GO:0016042//GO:0055114//GO:0007586 lipid catabolic process//oxidation-reduction process//digestion GO:0008047//GO:0016706 enzyme activator activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0005576 extracellular region -- -- Cluster-8309.13228 BP_3 4.00 0.37 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13232 BP_3 527.80 4.46 5994 642929078 XP_008195682.1 1247 9.8e-134 PREDICTED: venom metalloproteinase 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01562 Reprolysin family propeptide GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.13238 BP_3 16.00 0.48 1894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13242 BP_3 232.60 6.99 1895 642940135 XP_008191977.1 2032 2.9e-225 PREDICTED: probable tyrosyl-DNA phosphodiesterase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10862 TDP1 tyrosyl-DNA phosphodiesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10862 Q9VQM4 897 4.9e-95 Probable tyrosyl-DNA phosphodiesterase OS=Drosophila melanogaster GN=gkt PE=2 SV=1 PF06087 Tyrosyl-DNA phosphodiesterase GO:0006281 DNA repair GO:0008081 phosphoric diester hydrolase activity GO:0005634 nucleus KOG2031 Tyrosyl-DNA phosphodiesterase Cluster-8309.13243 BP_3 12.00 0.40 1751 755959480 XP_011304419.1 233 1.1e-16 PREDICTED: lysosome-associated membrane glycoprotein 1-like [Fopius arisanus]>gi|755959483|ref|XP_011304420.1| PREDICTED: lysosome-associated membrane glycoprotein 1-like [Fopius arisanus] 262401020 FJ774691.1 224 2.37036e-111 Scylla paramamosain lysosomal-associated membrane protein 1-like protein mRNA, partial cds K06528 LAMP1_2, CD107 lysosomal-associated membrane protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06528 P14562 204 1.0e-14 Lysosome-associated membrane glycoprotein 1 OS=Rattus norvegicus GN=Lamp1 PE=1 SV=1 PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.13244 BP_3 19.50 0.46 2326 189233840 XP_001809010.1 385 3.4e-34 PREDICTED: nucleolar transcription factor 1-like [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 256 1.3e-20 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13247 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13249 BP_3 27.32 0.45 3196 91088973 XP_966480.1 3025 0.0e+00 PREDICTED: G protein-coupled receptor kinase 1 [Tribolium castaneum]>gi|270011553|gb|EFA08001.1| hypothetical protein TcasGA2_TC005590 [Tribolium castaneum] 642932569 XM_961387.2 783 0 PREDICTED: Tribolium castaneum G protein-coupled receptor kinase 1 (LOC654946), mRNA K00910 ADRBK, GRK beta-adrenergic-receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00910 P32865 2694 3.5e-303 G protein-coupled receptor kinase 1 OS=Drosophila melanogaster GN=Gprk1 PE=2 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310//GO:0038032 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//termination of G-protein coupled receptor signaling pathway GO:0004703//GO:0004672//GO:0016773//GO:0005524 G-protein coupled receptor kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0986 G protein-coupled receptor kinase Cluster-8309.13252 BP_3 61.25 0.62 5034 672033453 XP_008756456.1 424 2.2e-38 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 160-like isoform X1, partial [Rattus norvegicus] 642924758 XM_008196206.1 138 4.42684e-63 PREDICTED: Tribolium castaneum PR domain zinc finger protein 1 (LOC100142159), transcript variant X4, mRNA -- -- -- -- Q61116 419 3.5e-39 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF13912//PF00856//PF13465//PF00096 C2H2-type zinc finger//SET domain//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- -- -- Cluster-8309.13255 BP_3 255.00 14.98 1112 91088415 XP_966747.1 343 1.2e-29 PREDICTED: nucleolar protein 12 [Tribolium castaneum]>gi|270012198|gb|EFA08646.1| hypothetical protein TcasGA2_TC006309 [Tribolium castaneum] -- -- -- -- -- K14851 RRP17, NOL12 ribosomal RNA-processing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K14851 Q8BG17 128 4.3e-06 Nucleolar protein 12 OS=Mus musculus GN=Nol12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13256 BP_3 5.00 0.41 878 642926415 XP_008191953.1 154 7.9e-08 PREDICTED: uncharacterized protein LOC659527 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12153 LPS binding domain of CAP18 (C terminal) GO:0042742 defense response to bacterium -- -- -- -- -- -- Cluster-8309.13257 BP_3 96.75 2.40 2235 546676764 ERL87718.1 1377 3.1e-149 hypothetical protein D910_05108 [Dendroctonus ponderosae] -- -- -- -- -- K08588 BAP1, UCHL2 ubiquitin carboxyl-terminal hydrolase BAP1 http://www.genome.jp/dbget-bin/www_bget?ko:K08588 Q17N72 678 1.4e-69 Ubiquitin carboxyl-terminal hydrolase calypso OS=Aedes aegypti GN=calypso PE=3 SV=1 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006508//GO:0006511//GO:0016579 proteolysis//ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0004843 ubiquitin-specific protease activity GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.13260 BP_3 2.00 0.32 597 270016377 EFA12823.1 170 7.5e-10 latrophilin-like receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z173 123 8.7e-06 Latrophilin-3 OS=Rattus norvegicus GN=Lphn3 PE=2 SV=1 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.13262 BP_3 3.00 0.43 628 749777246 XP_011143488.1 249 5.5e-19 PREDICTED: uncharacterized protein LOC105185577 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13263 BP_3 2.00 0.77 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13266 BP_3 16.00 1.77 728 557776740 XP_005188008.1 320 3.7e-27 PREDICTED: cytochrome c oxidase subunit NDUFA4-like [Musca domestica] -- -- -- -- -- K03948 NDUFA4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03948 Q62425 168 6.4e-11 Cytochrome c oxidase subunit NDUFA4 OS=Mus musculus GN=Ndufa4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13268 BP_3 22406.23 1917.33 855 478256737 ENN76918.1 293 5.9e-24 hypothetical protein YQE_06565, partial [Dendroctonus ponderosae]>gi|546672595|gb|ERL84396.1| hypothetical protein D910_01829 [Dendroctonus ponderosae] 166208658 EU177511.1 42 1.69052e-10 Pinctada fucata shematrin-1 mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1327 BP_3 14.00 1.38 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13271 BP_3 26.36 0.60 2420 270001817 EEZ98264.1 1598 7.9e-175 hypothetical protein TcasGA2_TC000706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32PJ7 167 2.8e-10 Tensin-4 OS=Bos taurus GN=TNS4 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13272 BP_3 44.00 1.00 2415 642913117 XP_008201398.1 1458 1.4e-158 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13273 BP_3 84.06 2.12 2200 642913117 XP_008201398.1 1390 9.4e-151 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.5e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13274 BP_3 251.00 16.04 1046 478260367 ENN80114.1 1173 6.5e-126 hypothetical protein YQE_03473, partial [Dendroctonus ponderosae]>gi|546676629|gb|ERL87593.1| hypothetical protein D910_04984 [Dendroctonus ponderosae] 195380648 XM_002049047.1 97 5.55296e-41 Drosophila virilis mus209 (Dvir\mus209), mRNA K04802 PCNA proliferating cell nuclear antigen http://www.genome.jp/dbget-bin/www_bget?ko:K04802 P17917 1096 2.3e-118 Proliferating cell nuclear antigen OS=Drosophila melanogaster GN=PCNA PE=1 SV=2 PF04139//PF00705//PF02747 Rad9//Proliferating cell nuclear antigen, N-terminal domain//Proliferating cell nuclear antigen, C-terminal domain GO:0000077//GO:0006275 DNA damage checkpoint//regulation of DNA replication GO:0003677 DNA binding GO:0030896 checkpoint clamp complex KOG1636 DNA polymerase delta processivity factor (proliferating cell nuclear antigen) Cluster-8309.13275 BP_3 36.00 2.66 943 226968617 YP_002808566.1 837 5.4e-87 ATP synthase F0 subunit 6 [Scylla paramamosain]>gi|225697853|gb|ACO07220.1| ATP synthase F0 subunit 6 [Scylla paramamosain]>gi|403311092|gb|AFR34051.1| ATP synthase F0 subunit 6 (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 940 0 Scylla paramamosain mitochondrion, complete genome K02126 ATPeF0A, MTATP6, ATP6 F-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02126 P33507 620 3.2e-63 ATP synthase subunit a OS=Anopheles quadrimaculatus GN=ATP6 PE=3 SV=1 PF00895 ATP synthase protein 8 GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276//GO:0045263//GO:0005743 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//proton-transporting ATP synthase complex, coupling factor F(o)//mitochondrial inner membrane KOG4665 ATP synthase F0 subunit 6 and related proteins Cluster-8309.13276 BP_3 13.19 1.08 878 328701369 XP_003241578.1 816 1.4e-84 PREDICTED: KRAB-A domain-containing protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6ZNG9 574 6.5e-58 KRAB-A domain-containing protein 2 OS=Homo sapiens GN=KRBA2 PE=1 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.13277 BP_3 40.82 0.82 2682 328701369 XP_003241578.1 565 5.3e-55 PREDICTED: KRAB-A domain-containing protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6R2W3 495 2.9e-48 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 PF06184//PF00665 Potexvirus coat protein//Integrase core domain GO:0015074 DNA integration GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.13279 BP_3 21.00 4.70 507 71067609 AAZ22828.1 323 1.2e-27 lymphoid organ expressed yellow head virus receptor protein [Penaeus monodon] 874473734 XM_005019619.2 50 3.4867e-15 PREDICTED: Anas platyrhynchos ribosomal protein L22-like 1 (RPL22L1), mRNA K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 255 3.7e-21 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 PF01776 Ribosomal L22e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3434 60S ribosomal protein L22 Cluster-8309.13282 BP_3 113.84 3.15 2035 332375354 AEE62818.1 512 5.6e-49 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CY62 312 3.6e-27 E3 ubiquitin-protein ligase RNF181 OS=Mus musculus GN=Rnf181 PE=2 SV=1 PF11789//PF00097//PF17122//PF17123//PF12906//PF12678//PF00628//PF14634//PF13639//PF03854//PF12861 Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//RING-like zinc finger//RING-variant domain//RING-H2 zinc finger//PHD-finger//zinc-RING finger domain//Ring finger domain//P-11 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0003723//GO:0005515//GO:0046872//GO:0004842 zinc ion binding//RNA binding//protein binding//metal ion binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.13298 BP_3 1.15 0.76 361 815820492 XP_012231463.1 166 1.3e-09 PREDICTED: SEC14-like protein 2 [Linepithema humile]>gi|815820494|ref|XP_012231464.1| PREDICTED: SEC14-like protein 2 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.133 BP_3 28.00 1.46 1213 642932555 XP_008197163.1 203 2.3e-13 PREDICTED: LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13300 BP_3 16.55 0.54 1769 270007077 EFA03525.1 1398 9.0e-152 hypothetical protein TcasGA2_TC013527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 442 2.6e-42 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13302 BP_3 11.00 2.38 514 642940025 XP_008191587.1 209 1.9e-14 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P19174 134 4.0e-07 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens GN=PLCG1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1264 Phospholipase C Cluster-8309.13304 BP_3 39.82 1.85 1332 642916934 XP_008199560.1 1109 2.2e-118 PREDICTED: serine/threonine-protein kinase HSL1 [Tribolium castaneum] 642916933 XM_008201338.1 292 2.83299e-149 PREDICTED: Tribolium castaneum serine/threonine-protein kinase HSL1 (LOC660568), mRNA K08853 AAK AP2-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08853 F1MH24 750 3.8e-78 AP2-associated protein kinase 1 OS=Bos taurus GN=AAK1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1989 ARK protein kinase family Cluster-8309.13305 BP_3 206647.00 4811.08 2362 288440 CAA51290.1 432 1.2e-39 acp-22 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P26968 423 5.6e-40 Adult-specific cuticular protein ACP-22 OS=Tenebrio molitor GN=ACP22 PE=2 SV=1 PF00379//PF07415 Insect cuticle protein//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency GO:0042302 structural constituent of cuticle GO:0033644 host cell membrane -- -- Cluster-8309.13307 BP_3 88.93 13.18 617 91085373 XP_971748.1 502 2.5e-48 PREDICTED: CDGSH iron-sulfur domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|270008416|gb|EFA04864.1| hypothetical protein TcasGA2_TC014918 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AR13 241 1.9e-19 CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Mus musculus GN=Cisd3 PE=1 SV=1 PF09360 Iron-binding zinc finger CDGSH type -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG4605 Uncharacterized conserved protein containing CDGSH-type Zn-finger Cluster-8309.13309 BP_3 6.69 0.31 1326 91091784 XP_969757.1 225 7.0e-16 PREDICTED: STAM-binding protein-like [Tribolium castaneum]>gi|270001088|gb|EEZ97535.1| hypothetical protein TcasGA2_TC011383 [Tribolium castaneum] -- -- -- -- -- K11867 STAMBPL1 AMSH-like protease http://www.genome.jp/dbget-bin/www_bget?ko:K11867 Q6TH47 186 9.6e-13 STAM-binding protein-like A OS=Danio rerio GN=stambpa PE=2 SV=3 PF10278 Mediator of RNA pol II transcription subunit 19 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2880 SMAD6 interacting protein AMSH, contains JAB/MPN/Mov34 domain Cluster-8309.13310 BP_3 1054.97 11.00 4916 478257469 ENN77625.1 1057 8.7e-112 hypothetical protein YQE_05919, partial [Dendroctonus ponderosae]>gi|546679863|gb|ERL90251.1| hypothetical protein D910_07603 [Dendroctonus ponderosae] -- -- -- -- -- K11502 CENPJ centromere protein J http://www.genome.jp/dbget-bin/www_bget?ko:K11502 Q9HC77 558 2.6e-55 Centromere protein J OS=Homo sapiens GN=CENPJ PE=1 SV=2 PF01395//PF06305//PF16331 PBP/GOBP family//Protein of unknown function (DUF1049)//TolA binding protein trimerisation GO:0070206 protein trimerization GO:0005549 odorant binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.13311 BP_3 15.00 1.03 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.13312 BP_3 357.60 12.44 1677 91082969 XP_973818.1 1001 9.2e-106 PREDICTED: ubiquitin-conjugating enzyme E2 J2 [Tribolium castaneum]>gi|270007042|gb|EFA03490.1| hypothetical protein TcasGA2_TC013489 [Tribolium castaneum] -- -- -- -- -- K04554 UBE2J2, NCUBE2, UBC6 ubiquitin-conjugating enzyme E2 J2 http://www.genome.jp/dbget-bin/www_bget?ko:K04554 Q8N2K1 777 3.6e-81 Ubiquitin-conjugating enzyme E2 J2 OS=Homo sapiens GN=UBE2J2 PE=1 SV=3 -- -- -- -- GO:0016881 acid-amino acid ligase activity -- -- KOG0894 Ubiquitin-protein ligase Cluster-8309.13314 BP_3 428.82 7.00 3245 642927336 XP_974968.2 1448 2.6e-157 PREDICTED: protein prune homolog 2 [Tribolium castaneum] -- -- -- -- -- K18449 PRUNE2, BMCC1 prune homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18449 Q5BJR4 507 1.4e-49 Protein prune homolog 2 OS=Rattus norvegicus GN=Prune2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1332 BP_3 17.50 0.93 1194 270004813 EFA01261.1 524 1.3e-50 cytochrome P450 303A1 [Tribolium castaneum] -- -- -- -- -- K07418 CYP2J cytochrome P450, family 2, subfamily J http://www.genome.jp/dbget-bin/www_bget?ko:K07418 Q9V399 324 8.6e-29 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.13320 BP_3 14.00 1.43 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13321 BP_3 35.65 0.38 4755 270004778 EFA01226.1 1400 1.4e-151 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1062 9.1e-114 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF15015//PF00665//PF11468 Spermatogenesis-associated, N-terminal//Integrase core domain//Aromatic prenyltransferase Orf2 GO:0007283//GO:0015074 spermatogenesis//DNA integration GO:0016740 transferase activity GO:0005794 Golgi apparatus -- -- Cluster-8309.13322 BP_3 91.57 1.21 3951 642934826 XP_008197826.1 2876 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1353 1.4e-147 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.13323 BP_3 66.43 1.35 2671 642921104 XP_008192691.1 1190 1.8e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.7e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF15678//PF07271 Centriole duplication and mitotic chromosome congression//Cytadhesin P30/P32 GO:0009405//GO:0007157//GO:0090307 pathogenesis//heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules//mitotic spindle assembly -- -- GO:0016021 integral component of membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.13327 BP_3 10.00 0.45 1359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13328 BP_3 17.00 0.77 1356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02805 Metal binding domain of Ada GO:0006355//GO:0006281 regulation of transcription, DNA-templated//DNA repair GO:0003677//GO:0008168//GO:0008270 DNA binding//methyltransferase activity//zinc ion binding -- -- -- -- Cluster-8309.13329 BP_3 1.00 0.83 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1333 BP_3 9.00 0.35 1543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13331 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13338 BP_3 252.29 15.55 1074 478254654 ENN74895.1 839 3.6e-87 hypothetical protein YQE_08473, partial [Dendroctonus ponderosae] 817052986 XM_012404120.1 175 2.49125e-84 PREDICTED: Athalia rosae SUMO-conjugating enzyme UBC9-B (LOC105688078), mRNA K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 Q9DDJ0 751 2.4e-78 SUMO-conjugating enzyme UBC9-B OS=Danio rerio GN=ube2ib PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.13339 BP_3 19.59 0.38 2796 642915549 XP_008190662.1 721 4.5e-73 PREDICTED: RNA-binding protein 25 isoform X1 [Tribolium castaneum]>gi|270003846|gb|EFA00294.1| hypothetical protein TcasGA2_TC003127 [Tribolium castaneum] -- -- -- -- -- K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 306 2.5e-26 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006397 mRNA processing GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.13343 BP_3 41.55 1.02 2261 91083483 XP_971803.1 1715 2.0e-188 PREDICTED: tubulin polyglutamylase TTLL4 [Tribolium castaneum]>gi|270010834|gb|EFA07282.1| hypothetical protein TcasGA2_TC014517 [Tribolium castaneum] -- -- -- -- -- K16610 TTLL15 tubulin monoglycylase TTLL15 http://www.genome.jp/dbget-bin/www_bget?ko:K16610 A4Q9E8 267 6.6e-22 Tubulin polyglutamylase TTLL6 OS=Mus musculus GN=Ttll6 PE=2 SV=1 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.13344 BP_3 13.00 1.62 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13346 BP_3 393.76 18.40 1323 91092522 XP_971244.1 767 9.9e-79 PREDICTED: pleckstrin homology domain-containing family A member 3 isoform X2 [Tribolium castaneum]>gi|270012906|gb|EFA09354.1| hypothetical protein TcasGA2_TC001680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ERS4 573 1.3e-57 Pleckstrin homology domain-containing family A member 3 OS=Mus musculus GN=Plekha3 PE=2 SV=1 -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.13347 BP_3 31.26 0.86 2041 642934345 XP_008198611.1 490 2.0e-46 PREDICTED: pleckstrin homology domain-containing family A member 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08051 PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08051 Q9ERS4 374 2.3e-34 Pleckstrin homology domain-containing family A member 3 OS=Mus musculus GN=Plekha3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1737 Oxysterol-binding protein Cluster-8309.13348 BP_3 1.00 0.31 446 321468065 EFX79052.1 294 2.3e-24 hypothetical protein DAPPUDRAFT_305046 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13351 BP_3 333.78 3.15 5407 164698394 NP_001106934.1 1464 6.1e-159 timeless isoform A [Tribolium castaneum]>gi|140270872|gb|ABO86540.1| TIMELESS isoform A [Tribolium castaneum] -- -- -- -- -- K12074 TIM timeless http://www.genome.jp/dbget-bin/www_bget?ko:K12074 P49021 1125 5.1e-121 Protein timeless OS=Drosophila melanogaster GN=tim PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13352 BP_3 12.13 0.45 1581 642939614 XP_008193596.1 396 1.2e-35 PREDICTED: protein MAATS1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BRC6 202 1.6e-14 Protein MAATS1 OS=Mus musculus GN=Maats1 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13353 BP_3 83.75 13.05 601 195117344 XP_002003207.1 173 3.4e-10 GI17786 [Drosophila mojavensis]>gi|193913782|gb|EDW12649.1| GI17786 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13355 BP_3 19.00 0.89 1326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13356 BP_3 4.00 0.79 536 662191560 XP_008468600.1 161 7.4e-09 PREDICTED: uncharacterized protein LOC103505997 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07174//PF05995 Fibronectin-attachment protein (FAP)//Cysteine dioxygenase type I GO:0055114//GO:0046439//GO:0019530//GO:0006534 oxidation-reduction process//L-cysteine metabolic process//taurine metabolic process//cysteine metabolic process GO:0050840//GO:0005506//GO:0017172 extracellular matrix binding//iron ion binding//cysteine dioxygenase activity GO:0005576 extracellular region -- -- Cluster-8309.13358 BP_3 4.26 0.44 759 478259797 ENN79625.1 358 1.5e-31 hypothetical protein YQE_03914, partial [Dendroctonus ponderosae]>gi|478269270|gb|ENN83314.1| hypothetical protein YQE_00330, partial [Dendroctonus ponderosae] -- -- -- -- -- K14860 TMA16 translation machinery-associated protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K14860 Q9VXY4 238 5.1e-19 Translation machinery-associated protein 16 homolog OS=Drosophila melanogaster GN=CG15027 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13359 BP_3 24.00 2.42 769 195542173 ACF98297.1 891 2.4e-93 heat shock protein 70 [Eriocheir sinensis] 418206098 JX913782.1 759 0 Scylla paramamosain isolate S6 heat shock protein 70 (hsp70) gene, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P47773 776 2.1e-81 Heat shock cognate 71 kDa protein OS=Ictalurus punctatus GN=hsc70 PE=2 SV=1 PF02491//PF04625 SHS2 domain inserted in FTSA//DEC-1 protein, N-terminal region GO:0007304//GO:0007049 chorion-containing eggshell formation//cell cycle GO:0005515//GO:0005213 protein binding//structural constituent of chorion GO:0042600//GO:0005576 chorion//extracellular region KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.13360 BP_3 7.00 13.20 299 170585537 XP_001897539.1 323 6.8e-28 60S ribosomal protein L38 [Brugia malayi]>gi|402588086|gb|EJW82020.1| ribosomal protein L38e [Wuchereria bancrofti]>gi|671408505|emb|CDP98234.1| Protein BM-RPL-38, isoform a [Brugia malayi] 585661014 XM_006886393.1 112 6.69743e-50 PREDICTED: Elephantulus edwardii ribosomal protein L38 (RPL38), mRNA K02923 RP-L38e, RPL38 large subunit ribosomal protein L38e http://www.genome.jp/dbget-bin/www_bget?ko:K02923 Q95V84 309 1.2e-27 60S ribosomal protein L38 OS=Branchiostoma belcheri GN=RPL38 PE=3 SV=1 PF01781 Ribosomal L38e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3499 60S ribosomal protein L38 Cluster-8309.13362 BP_3 2.00 1.12 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13363 BP_3 417.00 14.32 1695 91091714 XP_966527.1 1206 1.6e-129 PREDICTED: elongation of very long chain fatty acids protein 4 [Tribolium castaneum]>gi|270000864|gb|EEZ97311.1| hypothetical protein TcasGA2_TC011121 [Tribolium castaneum] 642937216 XM_961434.2 195 3.02982e-95 PREDICTED: Tribolium castaneum elongation of very long chain fatty acids protein 4 (LOC654965), mRNA K10249 ELOVL4 elongation of very long chain fatty acids protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10249 Q95K73 646 5.6e-66 Elongation of very long chain fatty acids protein 4 OS=Macaca fascicularis GN=ELOVL4 PE=2 SV=1 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.13364 BP_3 27.00 0.92 1710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13366 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13375 BP_3 36.94 1.06 1970 531446277 AGT57843.1 1037 7.2e-110 cytochrome P450 314a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10723 SHD, CYP314A1 ecdysone 20-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K10723 Q9VUF8 625 1.8e-63 Ecdysone 20-monooxygenase OS=Drosophila melanogaster GN=shd PE=1 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.13379 BP_3 28.64 0.70 2274 642912135 XP_008200821.1 2047 6.4e-227 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C9W3 1000 6.7e-107 A disintegrin and metalloproteinase with thrombospondin motifs 2 OS=Mus musculus GN=Adamts2 PE=1 SV=2 PF08686//PF05372 PLAC (protease and lacunin) domain//Delta lysin family GO:0019836 hemolysis by symbiont of host erythrocytes GO:0008233 peptidase activity GO:0005576 extracellular region -- -- Cluster-8309.13380 BP_3 25.86 0.37 3646 270002520 EEZ98967.1 2808 0.0e+00 hypothetical protein TcasGA2_TC004822 [Tribolium castaneum] -- -- -- -- -- K08628 ADAMTS14 a disintegrin and metalloproteinase with thrombospondin motifs 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08628 Q8WXS8 1244 5.5e-135 A disintegrin and metalloproteinase with thrombospondin motifs 14 OS=Homo sapiens GN=ADAMTS14 PE=2 SV=2 PF00413//PF08686//PF01421//PF05372 Matrixin//PLAC (protease and lacunin) domain//Reprolysin (M12B) family zinc metalloprotease//Delta lysin family GO:0019836//GO:0006508 hemolysis by symbiont of host erythrocytes//proteolysis GO:0004222//GO:0008270//GO:0008233 metalloendopeptidase activity//zinc ion binding//peptidase activity GO:0031012//GO:0005576 extracellular matrix//extracellular region -- -- Cluster-8309.13381 BP_3 41.80 0.50 4296 642913566 XP_008201065.1 1668 1.1e-182 PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913568|ref|XP_008201066.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913570|ref|XP_008201067.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913572|ref|XP_008201068.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum] 642913571 XM_008202846.1 441 0 PREDICTED: Tribolium castaneum monocarboxylate transporter 12-like (LOC661034), transcript variant X4, mRNA -- -- -- -- Q7RTX9 251 9.0e-20 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.13382 BP_3 2.00 0.45 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13386 BP_3 209.64 8.30 1509 546682615 ERL92532.1 1415 8.2e-154 hypothetical protein D910_09845 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q499P8 634 1.2e-64 RUS1 family protein C16orf58 homolog OS=Rattus norvegicus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4249 Uncharacterized conserved protein Cluster-8309.13387 BP_3 44.48 9.64 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13389 BP_3 19.30 0.33 3085 642916459 XP_008191036.1 1097 1.3e-116 PREDICTED: sestrin homolog [Tribolium castaneum]>gi|642916461|ref|XP_008191037.1| PREDICTED: sestrin homolog [Tribolium castaneum] 642916460 XM_008192815.1 370 0 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 Q54WU6 233 7.9e-18 Sestrin homolog OS=Dictyostelium discoideum GN=DDB_G0279427 PE=3 SV=1 PF00124//PF04636 Photosynthetic reaction centre protein//PA26 p53-induced protein (sestrin) GO:0006118//GO:0009772//GO:0019684//GO:1901031 obsolete electron transport//photosynthetic electron transport in photosystem II//photosynthesis, light reaction//regulation of response to reactive oxygen species GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GO:0005634 nucleus -- -- Cluster-8309.1339 BP_3 7.77 0.56 956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13396 BP_3 16.28 0.36 2472 91086801 XP_973474.1 1300 2.9e-140 PREDICTED: transmembrane protein 8A [Tribolium castaneum]>gi|642929011|ref|XP_008195653.1| PREDICTED: transmembrane protein 8A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HCN3 160 1.8e-09 Transmembrane protein 8A OS=Homo sapiens GN=TMEM8A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.134 BP_3 26.00 1.28 1273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13400 BP_3 6.00 0.63 751 675366673 KFM59575.1 203 1.4e-13 hypothetical protein X975_12160, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10408 Ubiquitin elongating factor core GO:0016567//GO:0006511 protein ubiquitination//ubiquitin-dependent protein catabolic process GO:0034450 ubiquitin-ubiquitin ligase activity GO:0000151 ubiquitin ligase complex -- -- Cluster-8309.13401 BP_3 6.00 0.41 995 795010744 XP_011868774.1 221 1.5e-15 PREDICTED: uncharacterized protein LOC105562496 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13402 BP_3 10.00 2.43 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13404 BP_3 2.00 0.56 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13409 BP_3 376.64 7.25 2796 642921468 XP_974644.2 1126 4.9e-120 PREDICTED: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I [Tribolium castaneum]>gi|642921470|ref|XP_008192881.1| PREDICTED: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I [Tribolium castaneum] -- -- -- -- -- K10158 B3GAT3 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10158 O97422 602 1.2e-60 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I OS=Drosophila melanogaster GN=GlcAT-I PE=2 SV=2 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.13413 BP_3 4.28 0.37 850 189237193 XP_001808466.1 576 8.9e-57 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Tribolium castaneum] -- -- -- -- -- K09008 NDUFAF3 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09008 A1L1F1 232 2.8e-18 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Danio rerio GN=ndufaf3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3363 Uncharacterized conserved nuclear protein Cluster-8309.13415 BP_3 30.00 1.06 1656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06377 Adipokinetic hormone GO:0007165 signal transduction GO:0005179 hormone activity -- -- -- -- Cluster-8309.13419 BP_3 763.79 17.04 2452 270009116 EFA05564.1 1983 1.8e-219 hypothetical protein TcasGA2_TC015753 [Tribolium castaneum] 642926575 XM_008196705.1 163 2.71198e-77 PREDICTED: Tribolium castaneum putative fatty acyl-CoA reductase CG5065 (LOC656109), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1034 8.3e-111 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01370//PF01118//PF01073 Male sterility protein//NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0008207//GO:0006694//GO:0055114//GO:0008209 estrogen metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process GO:0003854//GO:0003824//GO:0050662//GO:0051287//GO:0016616//GO:0080019//GO:0016620 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG1221 Acyl-CoA reductase Cluster-8309.13421 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13422 BP_3 180.61 2.56 3692 478249945 ENN70452.1 1354 2.4e-146 hypothetical protein YQE_12955, partial [Dendroctonus ponderosae] 242018772 XM_002429803.1 87 7.26185e-35 Pediculus humanus corporis conserved hypothetical protein, mRNA K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8IWX8 487 3.3e-47 Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens GN=CHERP PE=1 SV=3 PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.13423 BP_3 19.28 1.75 824 642936176 XP_008198328.1 869 9.2e-91 PREDICTED: fibronectin type III domain-containing protein 4 [Tribolium castaneum] 194880702 XM_001974468.1 91 9.38325e-38 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.13427 BP_3 41.78 0.53 4103 642923183 XP_008193645.1 2040 7.5e-226 PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923185|ref|XP_008193646.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923187|ref|XP_008193647.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923189|ref|XP_008193648.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3Z5L6 711 3.9e-73 MFS-type transporter SLC18B1 OS=Mus musculus GN=Slc18b1 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.1343 BP_3 14.00 0.48 1702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07651 ANTH domain -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.13439 BP_3 37.53 0.42 4641 270003682 EFA00130.1 872 2.3e-90 hypothetical protein TcasGA2_TC002946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 497 2.9e-48 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00507//PF13683//PF00665//PF00844 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3//Integrase core domain//Integrase core domain//Geminivirus coat protein/nuclear export factor BR1 family GO:0015074//GO:0055114//GO:0015992//GO:0006744//GO:0006814//GO:0006120 DNA integration//oxidation-reduction process//proton transport//ubiquinone biosynthetic process//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0005198 NADH dehydrogenase (ubiquinone) activity//structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.13441 BP_3 12.00 0.39 1794 478258669 ENN78719.1 1560 1.5e-170 hypothetical protein YQE_04891, partial [Dendroctonus ponderosae]>gi|546674941|gb|ERL86218.1| hypothetical protein D910_03629 [Dendroctonus ponderosae] 642922119 XM_008194802.1 182 5.41046e-88 PREDICTED: Tribolium castaneum uncharacterized LOC103312925 (LOC103312925), mRNA -- -- -- -- M9NEY8 400 2.0e-37 DNA N6-methyl adenine demethylase OS=Drosophila melanogaster GN=Tet PE=1 SV=1 PF02008//PF03094 CXXC zinc finger domain//Mlo family GO:0006952 defense response GO:0003677//GO:0008270 DNA binding//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.13447 BP_3 2.00 0.53 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13450 BP_3 10.00 1.94 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13451 BP_3 3.08 1.18 417 642918266 XP_008191438.1 236 1.2e-17 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 229 3.1e-18 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.13459 BP_3 398.42 13.14 1753 642911684 XP_008200700.1 1019 7.9e-108 PREDICTED: prohormone-4 [Tribolium castaneum]>gi|270015131|gb|EFA11579.1| brain peptide IDL-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P85831 845 4.9e-89 Prohormone-4 OS=Apis mellifera PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13460 BP_3 27.02 0.58 2528 642910803 XP_008193417.1 2334 3.7e-260 PREDICTED: LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2-like [Tribolium castaneum] -- -- -- -- -- K12326 RASGRF2 Ras-specific guanine nucleotide-releasing factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12326 P28818 958 5.5e-102 Ras-specific guanine nucleotide-releasing factor 1 OS=Rattus norvegicus GN=Rasgrf1 PE=1 SV=1 PF00617 RasGEF domain GO:0007264//GO:0043087 small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.13461 BP_3 71.00 1.80 2190 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13462 BP_3 56.78 3.39 1098 189236939 XP_970278.2 267 7.8e-21 PREDICTED: histidine-rich glycoprotein [Tribolium castaneum]>gi|270008064|gb|EFA04512.1| hypothetical protein TcasGA2_TC016307 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 203 8.5e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.13467 BP_3 1.79 0.48 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1347 BP_3 12.00 0.45 1569 -- -- -- -- -- 697076289 XM_009654091.1 1360 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- PF05808//PF02088 Podoplanin//Ornatin GO:0007155//GO:0030193 cell adhesion//regulation of blood coagulation -- -- GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.13471 BP_3 171.85 1.34 6485 642912859 XP_008201283.1 280 1.4e-21 PREDICTED: diacylglycerol kinase theta isoform X1 [Tribolium castaneum] 642912874 XM_008203070.1 303 1.08042e-154 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- KOG1169 Diacylglycerol kinase Cluster-8309.13475 BP_3 176.66 2.53 3654 91089205 XP_966919.1 857 1.0e-88 PREDICTED: SPRY domain-containing SOCS box protein 3 [Tribolium castaneum]>gi|270012469|gb|EFA08917.1| hypothetical protein TcasGA2_TC006623 [Tribolium castaneum] -- -- -- -- -- K10345 SPSB3, SSB3 SPRY domain-containing SOCS box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10345 Q28DT9 420 1.9e-39 SPRY domain-containing SOCS box protein 3 OS=Xenopus tropicalis GN=spsb3 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.1348 BP_3 2.00 0.45 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13481 BP_3 32.22 0.32 5195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04947 Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.13482 BP_3 13.41 0.52 1535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09377 SBDS protein C-terminal domain GO:0042254 ribosome biogenesis -- -- -- -- -- -- Cluster-8309.13484 BP_3 44.50 1.34 1898 332376342 AEE63311.1 1435 4.9e-156 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01443 nagA, AMDHD2 N-acetylglucosamine-6-phosphate deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K01443 Q9VR81 1266 8.0e-138 Putative N-acetylglucosamine-6-phosphate deacetylase OS=Drosophila melanogaster GN=CG17065 PE=2 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3892 N-acetyl-glucosamine-6-phosphate deacetylase Cluster-8309.13485 BP_3 37.28 1.12 1894 332376342 AEE63311.1 1271 5.1e-137 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01443 nagA, AMDHD2 N-acetylglucosamine-6-phosphate deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K01443 Q9VR81 1106 2.9e-119 Putative N-acetylglucosamine-6-phosphate deacetylase OS=Drosophila melanogaster GN=CG17065 PE=2 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3892 N-acetyl-glucosamine-6-phosphate deacetylase Cluster-8309.13486 BP_3 668.93 18.85 2002 332376342 AEE63311.1 1464 2.3e-159 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01443 nagA, AMDHD2 N-acetylglucosamine-6-phosphate deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K01443 Q9VR81 1300 9.7e-142 Putative N-acetylglucosamine-6-phosphate deacetylase OS=Drosophila melanogaster GN=CG17065 PE=2 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3892 N-acetyl-glucosamine-6-phosphate deacetylase Cluster-8309.13488 BP_3 88.91 2.29 2163 478254777 ENN75013.1 1536 1.1e-167 hypothetical protein YQE_08329, partial [Dendroctonus ponderosae] -- -- -- -- -- K11536 SLC28A pyrimidine nucleoside transport protein http://www.genome.jp/dbget-bin/www_bget?ko:K11536 Q62773 866 2.2e-91 Sodium/nucleoside cotransporter 2 OS=Rattus norvegicus GN=Slc28a2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3747 Concentrative Na+-nucleoside cotransporter CNT1/CNT2 Cluster-8309.13489 BP_3 57.00 3.03 1199 546683634 ERL93422.1 1037 4.4e-110 hypothetical protein D910_10714 [Dendroctonus ponderosae] -- -- -- -- -- K15336 TRDMT1, DNMT2 tRNA (cytosine38-C5)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15336 Q7YS61 644 6.7e-66 tRNA (cytosine-5-)-methyltransferase OS=Bos taurus GN=TRDMT1 PE=2 SV=1 PF09445 RNA cap guanine-N2 methyltransferase GO:0009452//GO:0001510 7-methylguanosine RNA capping//RNA methylation GO:0008168 methyltransferase activity -- -- KOG0919 C-5 cytosine-specific DNA methylase Cluster-8309.13492 BP_3 59.89 0.34 8704 332372792 AEE61538.1 1085 8.7e-115 unknown [Dendroctonus ponderosae] 805783396 XM_012284418.1 162 3.49545e-76 PREDICTED: Megachile rotundata tRNA (guanine-N(7)-)-methyltransferase (LOC100882994), transcript variant X3, mRNA K03439 trmB, METTL1 tRNA (guanine-N7-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03439 Q1HPU2 957 2.5e-101 tRNA (guanine-N(7)-)-methyltransferase OS=Bombyx mori PE=2 SV=1 PF13855//PF05175//PF02390//PF00560 Leucine rich repeat//Methyltransferase small domain//Putative methyltransferase//Leucine Rich Repeat GO:0009451//GO:0006400//GO:0008033 RNA modification//tRNA modification//tRNA processing GO:0008168//GO:0008176//GO:0005515 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//protein binding -- -- KOG3115 Methyltransferase-like protein Cluster-8309.13498 BP_3 352.25 9.20 2138 642916240 XP_008190943.1 1142 5.3e-122 PREDICTED: uncharacterized protein C630.12 [Tribolium castaneum]>gi|642916242|ref|XP_008190944.1| PREDICTED: uncharacterized protein C630.12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2I2M6 138 5.7e-07 Metallophosphoesterase 1 OS=Ailuropoda melanoleuca GN=MPPE1 PE=3 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3662 Cell division control protein/predicted DNA repair exonuclease Cluster-8309.13503 BP_3 56.40 22.23 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13507 BP_3 5.00 0.33 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1351 BP_3 20.42 0.63 1844 642928884 XP_008195602.1 1110 2.3e-118 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13511 BP_3 2.11 0.59 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13512 BP_3 495.82 7.14 3639 642919949 XP_008192140.1 1977 1.3e-218 PREDICTED: protein ovo isoform X2 [Tribolium castaneum] 524990254 XM_005042954.1 45 1.59359e-11 PREDICTED: Ficedula albicollis ovo-like 2 (Drosophila) (OVOL2), mRNA K09216 OVOL ovo http://www.genome.jp/dbget-bin/www_bget?ko:K09216 P51521 760 7.3e-79 Protein ovo OS=Drosophila melanogaster GN=ovo PE=1 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.13513 BP_3 22.00 5.75 476 296317355 NP_001171757.1 483 3.0e-46 40S ribosomal protein S24 [Saccoglossus kowalevskii] 268306387 GU084282.1 64 5.3763e-23 Manduca sexta ribosomal protein S24 (rps24) mRNA, complete cds K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 O42387 474 1.4e-46 40S ribosomal protein S24 OS=Takifugu rubripes GN=rps24 PE=3 SV=1 PF01282 Ribosomal protein S24e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3424 40S ribosomal protein S24 Cluster-8309.13514 BP_3 8.00 0.59 946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13517 BP_3 5.58 0.52 806 270013519 EFA09967.1 1111 7.8e-119 hypothetical protein TcasGA2_TC012125 [Tribolium castaneum] 808128212 XM_003397438.2 80 1.19456e-31 PREDICTED: Bombus terrestris 4-aminobutyrate aminotransferase, mitochondrial (LOC100648639), mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 P80147 803 1.7e-84 4-aminobutyrate aminotransferase, mitochondrial OS=Sus scrofa GN=ABAT PE=1 SV=2 PF00202//PF00155 Aminotransferase class-III//Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170//GO:0008483 pyridoxal phosphate binding//transaminase activity -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.13518 BP_3 5.00 0.82 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1352 BP_3 13.00 0.54 1457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13521 BP_3 1.00 2.95 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13523 BP_3 33.24 1.10 1747 546684056 ERL93779.1 1230 2.7e-132 hypothetical protein D910_11065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BDJ4 267 5.1e-22 Lipase member H OS=Oryctolagus cuniculus GN=LIPH PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13526 BP_3 212.97 5.11 2300 642919953 XP_008192142.1 1339 8.1e-145 PREDICTED: protein ovo isoform X4 [Tribolium castaneum] 524990254 XM_005042954.1 42 4.66238e-10 PREDICTED: Ficedula albicollis ovo-like 2 (Drosophila) (OVOL2), mRNA K09216 OVOL ovo http://www.genome.jp/dbget-bin/www_bget?ko:K09216 P51521 284 7.2e-24 Protein ovo OS=Drosophila melanogaster GN=ovo PE=1 SV=2 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- KOG3576 Ovo and related transcription factors Cluster-8309.13529 BP_3 190.00 4.48 2336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08500 Tombusvirus p33 GO:0006144 purine nucleobase metabolic process GO:0003968 RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.1353 BP_3 17.03 0.52 1857 642928884 XP_008195602.1 1110 2.3e-118 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13531 BP_3 38.87 1.04 2091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005743//GO:0005750 mitochondrial inner membrane//mitochondrial respiratory chain complex III -- -- Cluster-8309.13533 BP_3 9.00 0.40 1383 478263199 ENN81589.1 679 1.7e-68 hypothetical protein YQE_01999, partial [Dendroctonus ponderosae]>gi|546674113|gb|ERL85583.1| hypothetical protein D910_03002 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01881 CRISPR associated protein Cas6 -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.13539 BP_3 2.00 1.33 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1354 BP_3 21.32 0.68 1812 642928884 XP_008195602.1 1110 2.3e-118 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13541 BP_3 10.00 0.70 985 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13542 BP_3 112.00 3.73 1738 642912489 XP_008200886.1 1502 7.7e-164 PREDICTED: Fanconi anemia group I protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K368 476 3.0e-46 Fanconi anemia group I protein homolog OS=Mus musculus GN=Fanci PE=1 SV=2 PF04371 Porphyromonas-type peptidyl-arginine deiminase GO:0006807//GO:0009446 nitrogen compound metabolic process//putrescine biosynthetic process GO:0004668 protein-arginine deiminase activity -- -- KOG4553 Uncharacterized conserved protein Cluster-8309.13547 BP_3 8.86 1.78 532 478260310 ENN80062.1 394 7.1e-36 hypothetical protein YQE_03538, partial [Dendroctonus ponderosae]>gi|546678010|gb|ERL88734.1| hypothetical protein D910_06116 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13549 BP_3 13.28 0.35 2104 91094389 XP_971252.1 587 1.2e-57 PREDICTED: DNA polymerase epsilon subunit C [Tribolium castaneum] 642910354 XM_966159.2 83 6.87901e-33 PREDICTED: Tribolium castaneum DNA polymerase epsilon subunit C (LOC659892), mRNA -- -- -- -- Q2YDP3 205 9.5e-15 Dr1-associated corepressor OS=Bos taurus GN=DRAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1659 Class 2 transcription repressor NC2, alpha subunit (DRAP1) Cluster-8309.13555 BP_3 13.81 0.36 2132 795015935 XP_011858320.1 1069 1.5e-113 PREDICTED: uncharacterized protein LOC105555888 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.13556 BP_3 11.04 0.32 1978 795015935 XP_011858320.1 892 4.7e-93 PREDICTED: uncharacterized protein LOC105555888 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.13559 BP_3 74.62 0.89 4349 270004778 EFA01226.1 1701 1.6e-186 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1173 1.1e-126 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.1356 BP_3 15.23 0.49 1799 642928884 XP_008195602.1 1110 2.3e-118 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13569 BP_3 52.22 0.51 5213 558231171 XP_006139245.1 413 4.4e-37 PREDICTED: uncharacterized protein LOC102453386 [Pelodiscus sinensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 383 5.4e-35 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF00096//PF13465//PF10590//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//C2H2-type zinc finger//zinc-finger C2H2-type GO:0055114 oxidation-reduction process GO:0046872//GO:0016638 metal ion binding//oxidoreductase activity, acting on the CH-NH2 group of donors -- -- -- -- Cluster-8309.13572 BP_3 41.00 2.22 1182 478253464 ENN73791.1 1163 1.1e-124 hypothetical protein YQE_09571, partial [Dendroctonus ponderosae] -- -- -- -- -- K10743 RNASEH2A ribonuclease H2 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K10743 Q9VPP5 925 1.7e-98 Ribonuclease H2 subunit A OS=Drosophila melanogaster GN=CG13690 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2299 Ribonuclease HI Cluster-8309.13574 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13575 BP_3 65.39 1.08 3205 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.13584 BP_3 218.83 1.54 7145 642937579 XP_008199106.1 1348 2.3e-145 PREDICTED: protein bric-a-brac 1-like isoform X1 [Tribolium castaneum]>gi|270001234|gb|EEZ97681.1| hypothetical protein TcasGA2_TC016226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B87 360 3.4e-32 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00644//PF13851//PF04871//PF05485//PF00651//PF03938//PF10473 Poly(ADP-ribose) polymerase catalytic domain//Growth-arrest specific micro-tubule binding//Uso1 / p115 like vesicle tethering protein, C terminal region//THAP domain//BTB/POZ domain//Outer membrane protein (OmpH-like)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0048870//GO:0006886//GO:0015031 cell motility//intracellular protein transport//protein transport GO:0005515//GO:0003676//GO:0042803//GO:0003950//GO:0045502//GO:0008134//GO:0008565//GO:0051082 protein binding//nucleic acid binding//protein homodimerization activity//NAD+ ADP-ribosyltransferase activity//dynein binding//transcription factor binding//protein transporter activity//unfolded protein binding GO:0030286//GO:0005667//GO:0016020//GO:0031514//GO:0005737 dynein complex//transcription factor complex//membrane//motile cilium//cytoplasm -- -- Cluster-8309.13585 BP_3 20.00 0.81 1485 395484809 AFN66649.1 1733 1.1e-190 glutamine synthetase [Fenneropenaeus chinensis]>gi|395484811|gb|AFN66650.1| glutamine synthetase [Fenneropenaeus chinensis] 347327118 JN620540.1 485 0 Litopenaeus vannamei glutamine synthetase mRNA, complete cds K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 Q04831 1669 1.2e-184 Glutamine synthetase OS=Panulirus argus PE=2 SV=1 PF03951//PF00120 Glutamine synthetase, beta-Grasp domain//Glutamine synthetase, catalytic domain GO:0009252//GO:0006807//GO:0006542 peptidoglycan biosynthetic process//nitrogen compound metabolic process//glutamine biosynthetic process GO:0004356 glutamate-ammonia ligase activity -- -- KOG0683 Glutamine synthetase Cluster-8309.13586 BP_3 111.00 18.43 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1359 BP_3 17.00 1.12 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13594 BP_3 669.10 17.16 2171 531446277 AGT57843.1 1697 2.3e-186 cytochrome P450 314a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10723 SHD, CYP314A1 ecdysone 20-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K10723 Q9VUF8 1022 1.8e-109 Ecdysone 20-monooxygenase OS=Drosophila melanogaster GN=shd PE=1 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.13601 BP_3 53.34 1.05 2733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643//PF07776//PF00096 B-box zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634//GO:0005622 nucleus//intracellular -- -- Cluster-8309.13605 BP_3 4.38 0.41 801 662212463 XP_008479968.1 149 2.7e-07 PREDICTED: zinc finger protein 37-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF05184//PF00096//PF13465 C2H2-type zinc finger//Saposin-like type B, region 1//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006629 lipid metabolic process GO:0046872 metal ion binding -- -- -- -- Cluster-8309.13610 BP_3 180.33 7.36 1472 478251980 ENN72416.1 615 4.6e-61 hypothetical protein YQE_10934, partial [Dendroctonus ponderosae] -- -- -- -- -- K16599 TTLL1 tubulin polyglutamylase TTLL1 http://www.genome.jp/dbget-bin/www_bget?ko:K16599 Q5TUE9 553 3.0e-55 Probable 39S ribosomal protein L23, mitochondrial OS=Anopheles gambiae GN=mRpL23 PE=3 SV=1 PF03133//PF00276 Tubulin-tyrosine ligase family//Ribosomal protein L23 GO:0006464//GO:0006412//GO:0042254 cellular protein modification process//translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG4089 Predicted mitochondrial ribosomal protein L23 Cluster-8309.13611 BP_3 22.17 0.72 1774 91080323 XP_974474.1 917 5.4e-96 PREDICTED: probable tubulin polyglutamylase TTLL1 [Tribolium castaneum]>gi|270005605|gb|EFA02053.1| hypothetical protein TcasGA2_TC007682 [Tribolium castaneum] -- -- -- -- -- K16599 TTLL1 tubulin polyglutamylase TTLL1 http://www.genome.jp/dbget-bin/www_bget?ko:K16599 Q5PPI9 663 6.3e-68 Probable tubulin polyglutamylase TTLL1 OS=Rattus norvegicus GN=Ttll1 PE=2 SV=1 PF03133//PF00276 Tubulin-tyrosine ligase family//Ribosomal protein L23 GO:0006464//GO:0042254//GO:0006570//GO:0006412 cellular protein modification process//ribosome biogenesis//tyrosine metabolic process//translation GO:0003735//GO:0004835 structural constituent of ribosome//tubulin-tyrosine ligase activity GO:0005840 ribosome KOG4089 Predicted mitochondrial ribosomal protein L23 Cluster-8309.13612 BP_3 130.61 89.38 358 91078218 XP_969246.1 393 6.2e-36 PREDICTED: ubiquitin-like protein 5 [Tribolium castaneum]>gi|270002984|gb|EEZ99431.1| hypothetical protein TcasGA2_TC030562 [Tribolium castaneum] 815820526 XM_012376058.1 88 1.79654e-36 PREDICTED: Linepithema humile ubiquitin-like protein 5 (LOC105677441), mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q791B0 357 3.8e-33 Ubiquitin-like protein 5 OS=Psammomys obesus GN=UBL5 PE=3 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-8309.13613 BP_3 18.72 0.81 1412 817193593 XP_012272264.1 148 6.3e-07 PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193595|ref|XP_012272265.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193597|ref|XP_012272266.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.13614 BP_3 22.04 0.67 1874 768448419 XP_011566240.1 930 1.8e-97 PREDICTED: zinc finger BED domain-containing protein 1-like [Plutella xylostella] 641657692 XM_008182221.1 41 1.3615e-09 PREDICTED: Acyrthosiphon pisum zinc finger MYM-type protein 1-like (LOC103308579), mRNA -- -- -- -- O96006 336 5.5e-30 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 PF06363//PF05699//PF14372 Picornaviridae P3A protein//hAT family C-terminal dimerisation region//Domain of unknown function (DUF4413) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0019012 virion KOG1121 Tam3-transposase (Ac family) Cluster-8309.13615 BP_3 88.00 8.03 820 91076388 XP_968260.1 670 1.1e-67 PREDICTED: beta-sarcoglycan [Tribolium castaneum]>gi|270002457|gb|EEZ98904.1| hypothetical protein TcasGA2_TC004520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82349 165 1.6e-10 Beta-sarcoglycan OS=Mus musculus GN=Sgcb PE=1 SV=1 PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.13616 BP_3 18.00 5.24 457 91076388 XP_968260.1 233 2.8e-17 PREDICTED: beta-sarcoglycan [Tribolium castaneum]>gi|270002457|gb|EEZ98904.1| hypothetical protein TcasGA2_TC004520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016012//GO:0016021//GO:0044425 sarcoglycan complex//integral component of membrane//membrane part -- -- Cluster-8309.13624 BP_3 86.13 1.10 4063 642935200 XP_966348.3 1895 4.8e-209 PREDICTED: kelch-like ECH-associated protein 1 isoform X1 [Tribolium castaneum] 642935203 XM_008201467.1 297 1.46105e-151 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 967 8.1e-103 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF01344//PF00651//PF07646 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13628 BP_3 513.65 16.22 1818 91081441 XP_973723.1 1779 6.1e-196 PREDICTED: transmembrane protein 184C [Tribolium castaneum]>gi|270006131|gb|EFA02579.1| hypothetical protein TcasGA2_TC008297 [Tribolium castaneum] 749794019 XM_011152023.1 61 1.00612e-20 PREDICTED: Harpegnathos saltator transmembrane protein 184C (LOC105189732), transcript variant X4, mRNA -- -- -- -- Q3TPR7 949 4.4e-101 Transmembrane protein 184C OS=Mus musculus GN=Tmem184c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.13629 BP_3 19.00 0.54 1981 91081441 XP_973723.1 1325 2.9e-143 PREDICTED: transmembrane protein 184C [Tribolium castaneum]>gi|270006131|gb|EFA02579.1| hypothetical protein TcasGA2_TC008297 [Tribolium castaneum] 749794019 XM_011152023.1 52 1.10589e-15 PREDICTED: Harpegnathos saltator transmembrane protein 184C (LOC105189732), transcript variant X4, mRNA -- -- -- -- Q3TPR7 699 4.7e-72 Transmembrane protein 184C OS=Mus musculus GN=Tmem184c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.13631 BP_3 98.00 2.09 2551 91080903 XP_973591.1 1592 4.1e-174 PREDICTED: protein lethal(2)denticleless [Tribolium castaneum]>gi|270005936|gb|EFA02384.1| hypothetical protein TcasGA2_TC008061 [Tribolium castaneum] -- -- -- -- -- K11790 DTL, CDT2, DCAF2 denticleless http://www.genome.jp/dbget-bin/www_bget?ko:K11790 Q24371 940 6.8e-100 Protein lethal(2)denticleless OS=Drosophila melanogaster GN=l(2)dtl PE=1 SV=2 PF00111//PF00400 2Fe-2S iron-sulfur cluster binding domain//WD domain, G-beta repeat GO:0006118 obsolete electron transport GO:0005515//GO:0009055//GO:0051536 protein binding//electron carrier activity//iron-sulfur cluster binding -- -- KOG0321 WD40 repeat-containing protein L2DTL Cluster-8309.13633 BP_3 40.91 0.70 3119 270010355 EFA06803.1 662 3.5e-66 hypothetical protein TcasGA2_TC009742 [Tribolium castaneum] -- -- -- -- -- K11268 ESCO, ECO1 N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11268 Q8CIB9 324 2.2e-28 N-acetyltransferase ESCO2 OS=Mus musculus GN=Esco2 PE=2 SV=3 PF00583//PF13508//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3014 Protein involved in establishing cohesion between sister chromatids during DNA replication Cluster-8309.13634 BP_3 5.00 0.36 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13638 BP_3 26.21 0.74 1993 478252064 ENN72495.1 1107 5.6e-118 hypothetical protein YQE_10836, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VWN5 903 1.0e-95 Protein FAM188A homolog OS=Drosophila melanogaster GN=CG7332 PE=1 SV=1 PF13499//PF00036//PF13405 EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG2871 Uncharacterized conserved protein Cluster-8309.1364 BP_3 3.00 0.68 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13642 BP_3 1.46 1.11 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13646 BP_3 26.43 3.41 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0006865//GO:0003333 amino acid transport//amino acid transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.13647 BP_3 20.00 2.49 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13648 BP_3 1.00 1.35 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13649 BP_3 46.00 6.46 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1365 BP_3 33.37 2.52 929 270008045 EFA04493.1 178 1.4e-10 hypothetical protein TcasGA2_TC014799 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13651 BP_3 130.06 1.60 4205 91082901 XP_972219.1 678 6.6e-68 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Tribolium castaneum]>gi|270007610|gb|EFA04058.1| hypothetical protein TcasGA2_TC014291 [Tribolium castaneum] -- -- -- -- -- K13128 ZCCHC8 zinc finger CCHC domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13128 Q2PE14 512 4.8e-50 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2673 Uncharacterized conserved protein, contains PSP domain Cluster-8309.13652 BP_3 2.00 0.48 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13653 BP_3 38.63 1.06 2043 270008217 EFA04665.1 866 5.1e-90 cytochrome P450-like protein [Tribolium castaneum] 194753078 XM_001958810.1 37 2.48764e-07 Drosophila ananassae GF12357 (Dana\GF12357), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 O46051 638 5.7e-65 Probable cytochrome P450 4d14 OS=Drosophila melanogaster GN=Cyp4d14 PE=3 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.13654 BP_3 257.32 6.35 2245 91080515 XP_971732.1 865 7.3e-90 PREDICTED: galectin-8-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00214 372 4.4e-34 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.13658 BP_3 5.00 0.98 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13659 BP_3 12.00 0.90 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13661 BP_3 20.00 7.64 417 123389586 XP_001299746.1 294 2.2e-24 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121880660|gb|EAX86816.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q4UMH6 242 9.7e-20 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.13663 BP_3 8.82 0.32 1636 642919727 XP_970439.2 365 5.0e-32 PREDICTED: guanylate cyclase soluble subunit beta-1 [Tribolium castaneum]>gi|642919729|ref|XP_008192041.1| PREDICTED: guanylate cyclase soluble subunit beta-1 [Tribolium castaneum] -- -- -- -- -- K12319 GUCY1B guanylate cyclase soluble subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12319 P20595 329 3.1e-29 Guanylate cyclase soluble subunit beta-1 OS=Rattus norvegicus GN=Gucy1b3 PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556 cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0016849 phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.13664 BP_3 53.00 1.51 1981 478251617 ENN72078.1 175 6.6e-10 hypothetical protein YQE_11264, partial [Dendroctonus ponderosae]>gi|546674549|gb|ERL85905.1| hypothetical protein D910_03320 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13665 BP_3 32.00 0.56 3033 307173098 EFN64217.1 545 1.3e-52 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 343 1.4e-30 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.13666 BP_3 16.69 1.24 941 91080425 XP_968280.1 874 2.8e-91 PREDICTED: transmembrane protein 147 [Tribolium castaneum]>gi|270005752|gb|EFA02200.1| hypothetical protein TcasGA2_TC007856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DFI2 516 3.7e-51 Transmembrane protein 147 OS=Xenopus laevis GN=tmem147 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3236 Predicted membrane protein Cluster-8309.13667 BP_3 55.25 3.80 993 91085713 XP_972970.1 1055 3.0e-112 PREDICTED: cyclin-H [Tribolium castaneum]>gi|270010021|gb|EFA06469.1| hypothetical protein TcasGA2_TC009354 [Tribolium castaneum] -- -- -- -- -- K06634 CCNH cyclin H http://www.genome.jp/dbget-bin/www_bget?ko:K06634 Q9R1A0 539 8.4e-54 Cyclin-H OS=Rattus norvegicus GN=Ccnh PE=2 SV=2 PF02984//PF00382//PF01857 Cyclin, C-terminal domain//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain GO:0000079//GO:0006355//GO:0051726 regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated//regulation of cell cycle GO:0017025//GO:0019901 TBP-class protein binding//protein kinase binding GO:0005675//GO:0005634 holo TFIIH complex//nucleus KOG2496 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit Cluster-8309.13670 BP_3 105.18 0.76 6967 642917395 XP_008191178.1 2504 2.0e-279 PREDICTED: DNA ligase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 P51892 2116 8.1e-236 DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1 PF01331//PF13414//PF04675//PF00515//PF04679//PF01068//PF13174//PF03971//PF13181 mRNA capping enzyme, catalytic domain//TPR repeat//DNA ligase N terminus//Tetratricopeptide repeat//ATP dependent DNA ligase C terminal region//ATP dependent DNA ligase domain//Tetratricopeptide repeat//Monomeric isocitrate dehydrogenase//Tetratricopeptide repeat GO:0006397//GO:0006749//GO:0019643//GO:0006281//GO:0006099//GO:0006370//GO:0006310//GO:0006260//GO:0055114 mRNA processing//glutathione metabolic process//reductive tricarboxylic acid cycle//DNA repair//tricarboxylic acid cycle//7-methylguanosine mRNA capping//DNA recombination//DNA replication//oxidation-reduction process GO:0005524//GO:0003677//GO:0005515//GO:0004484//GO:0003910//GO:0004450 ATP binding//DNA binding//protein binding//mRNA guanylyltransferase activity//DNA ligase (ATP) activity//isocitrate dehydrogenase (NADP+) activity -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.13672 BP_3 49.00 2.20 1366 642921880 XP_008192928.1 713 1.9e-72 PREDICTED: uncharacterized protein LOC100141968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156//PF00115//PF02536 Protein of unknown function (DUF972)//Cytochrome C and Quinol oxidase polypeptide I//mTERF GO:0006260//GO:0006355//GO:0006118//GO:0015992//GO:0055114//GO:0009060//GO:0006123 DNA replication//regulation of transcription, DNA-templated//obsolete electron transport//proton transport//oxidation-reduction process//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen GO:0009055//GO:0005506//GO:0003690//GO:0020037//GO:0004129 electron carrier activity//iron ion binding//double-stranded DNA binding//heme binding//cytochrome-c oxidase activity GO:0005739//GO:0016021//GO:0045277 mitochondrion//integral component of membrane//respiratory chain complex IV -- -- Cluster-8309.13675 BP_3 327.62 11.10 1714 91083689 XP_966502.1 1090 4.5e-116 PREDICTED: hydroxysteroid dehydrogenase-like protein 1 [Tribolium castaneum]>gi|642924362|ref|XP_008194265.1| PREDICTED: hydroxysteroid dehydrogenase-like protein 1 [Tribolium castaneum]>gi|642924364|ref|XP_008194266.1| PREDICTED: hydroxysteroid dehydrogenase-like protein 1 [Tribolium castaneum] -- -- -- -- -- K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10251 Q3SXM5 617 1.3e-62 Inactive hydroxysteroid dehydrogenase-like protein 1 OS=Homo sapiens GN=HSDL1 PE=1 SV=3 PF01370//PF00106//PF01356 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Alpha amylase inhibitor GO:0008152 metabolic process GO:0015066//GO:0050662//GO:0003824//GO:0016491 alpha-amylase inhibitor activity//coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.13678 BP_3 5.00 0.49 785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13684 BP_3 12.53 1.42 716 642924854 XP_008194067.1 572 2.2e-56 PREDICTED: LOW QUALITY PROTEIN: protein mahjong [Tribolium castaneum] -- -- -- -- -- K11789 VPRBP, DCAF1 HIV-1 Vpr-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11789 Q9W2F2 392 6.7e-37 Protein mahjong OS=Drosophila melanogaster GN=mahj PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1832 HIV-1 Vpr-binding protein Cluster-8309.13692 BP_3 83.36 4.37 1212 91087671 XP_976426.1 329 5.6e-28 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13693 BP_3 2.54 0.79 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13695 BP_3 10.82 2.12 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13696 BP_3 1.00 0.70 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13698 BP_3 59.00 2.79 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1370 BP_3 2.00 0.59 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13702 BP_3 11.71 0.53 1366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13704 BP_3 125.90 1.68 3901 546673691 ERL85252.1 406 2.1e-36 hypothetical protein D910_02673 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06009//PF01544 Laminin Domain II//CorA-like Mg2+ transporter protein GO:0030001//GO:0007155//GO:0055085 metal ion transport//cell adhesion//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.13709 BP_3 154.67 4.09 2113 478257072 ENN77235.1 322 6.3e-27 hypothetical protein YQE_06065, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- F1R983 136 9.6e-07 DNA endonuclease RBBP8 OS=Danio rerio GN=rbbp8 PE=2 SV=1 PF08573//PF02050 DNA repair protein endonuclease SAE2/CtIP C-terminus//Flagellar FliJ protein GO:0000077//GO:0006308//GO:0006935//GO:0006281//GO:0071973 DNA damage checkpoint//DNA catabolic process//chemotaxis//DNA repair//bacterial-type flagellum-dependent cell motility GO:0003774//GO:0000014 motor activity//single-stranded DNA endodeoxyribonuclease activity GO:0016020//GO:0009288 membrane//bacterial-type flagellum -- -- Cluster-8309.13710 BP_3 0.97 1.71 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13714 BP_3 109.00 6.48 1103 91082171 XP_970910.1 848 3.3e-88 PREDICTED: N-terminal Xaa-Pro-Lys N-methyltransferase 1 [Tribolium castaneum]>gi|270007239|gb|EFA03687.1| hypothetical protein TcasGA2_TC013789 [Tribolium castaneum] -- -- -- -- -- K16219 NTMT1, METTL11A, NTM1 protein N-terminal methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K16219 B1H2P7 534 3.5e-53 N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Xenopus tropicalis GN=ntmt1 PE=2 SV=1 PF08241//PF05175//PF05891//PF00891 Methyltransferase domain//Methyltransferase small domain//AdoMet dependent proline di-methyltransferase//O-methyltransferase GO:0032259//GO:0008152//GO:0006480 methylation//metabolic process//N-terminal protein amino acid methylation GO:0008171//GO:0008168 O-methyltransferase activity//methyltransferase activity -- -- KOG3178 Hydroxyindole-O-methyltransferase and related SAM-dependent methyltransferases Cluster-8309.13715 BP_3 148.60 4.28 1967 546674382 ERL85769.1 1622 1.1e-177 hypothetical protein D910_03184 [Dendroctonus ponderosae] -- -- -- -- -- K17609 NXN nucleoredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K17609 Q6DKJ4 530 1.8e-52 Nucleoredoxin OS=Homo sapiens GN=NXN PE=1 SV=2 PF00578//PF00832//PF08534//PF00085 AhpC/TSA family//Ribosomal L39 protein//Redoxin//Thioredoxin GO:0045454//GO:0042254//GO:0055114//GO:0006412 cell redox homeostasis//ribosome biogenesis//oxidation-reduction process//translation GO:0003735//GO:0016209//GO:0016491 structural constituent of ribosome//antioxidant activity//oxidoreductase activity GO:0005840//GO:0005622 ribosome//intracellular KOG2501 Thioredoxin, nucleoredoxin and related proteins Cluster-8309.1372 BP_3 13.09 0.97 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13723 BP_3 564.60 7.95 3716 642914904 XP_008190437.1 1291 4.8e-139 PREDICTED: aldehyde dehydrogenase 5, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T1L0 282 2.0e-23 Aldehyde dehydrogenase family 16 member A1 OS=Rattus norvegicus GN=Aldh16a1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.13730 BP_3 629.00 18.23 1955 642912516 XP_008200897.1 2171 2.3e-241 PREDICTED: slit homolog 1 protein [Tribolium castaneum] 749730939 XM_011145586.1 75 1.78748e-28 PREDICTED: Harpegnathos saltator slit homolog 1 protein (LOC105185782), mRNA -- -- -- -- P08953 384 1.6e-35 Protein toll OS=Drosophila melanogaster GN=Tl PE=1 SV=1 PF13855//PF13676//PF01582 Leucine rich repeat//TIR domain//TIR domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.13731 BP_3 536.00 12.40 2375 270002906 EEZ99353.1 3532 0.0e+00 tollo [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70389 455 1.1e-43 Insulin-like growth factor-binding protein complex acid labile subunit OS=Mus musculus GN=Igfals PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13736 BP_3 3.00 0.47 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13737 BP_3 6.96 0.63 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13738 BP_3 5.04 0.33 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13739 BP_3 120.69 1.60 3935 642916598 XP_008191833.1 2092 6.7e-232 PREDICTED: limbic system-associated membrane protein-like [Tribolium castaneum] 642916597 XM_008193611.1 147 3.42908e-68 PREDICTED: Tribolium castaneum limbic system-associated membrane protein-like (LOC658191), mRNA -- -- -- -- A2AJ76 321 6.3e-28 Hemicentin-2 OS=Mus musculus GN=Hmcn2 PE=2 SV=1 PF13895//PF00041//PF16656 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.13741 BP_3 3.00 0.34 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13744 BP_3 14.64 0.40 2050 260785084 XP_002587593.1 287 7.0e-23 hypothetical protein BRAFLDRAFT_230456 [Branchiostoma floridae]>gi|229272742|gb|EEN43604.1| hypothetical protein BRAFLDRAFT_230456 [Branchiostoma floridae] -- -- -- -- -- K06641 CHK2 serine/threonine-protein kinase Chk2 http://www.genome.jp/dbget-bin/www_bget?ko:K06641 O61267 232 6.9e-18 Ovarian-specific serine/threonine-protein kinase Lok OS=Drosophila melanogaster GN=lok PE=2 SV=1 PF07714//PF00498//PF00069 Protein tyrosine kinase//FHA domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- KOG0583 Serine/threonine protein kinase Cluster-8309.13746 BP_3 160.18 7.23 1359 332375989 AEE63135.1 1240 1.4e-133 unknown [Dendroctonus ponderosae]>gi|478258650|gb|ENN78700.1| hypothetical protein YQE_04872, partial [Dendroctonus ponderosae] 645003560 XR_512750.1 92 4.371e-38 PREDICTED: Nasonia vitripennis kidney mitochondrial carrier protein 1 (LOC100120159), transcript variant X2, misc_RNA K15106 SLC25A14_30 solute carrier family 25 (mitochondrial carrier), member 14/30 http://www.genome.jp/dbget-bin/www_bget?ko:K15106 Q9CR58 796 1.8e-83 Kidney mitochondrial carrier protein 1 OS=Mus musculus GN=Slc25a30 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.13748 BP_3 6.32 0.35 1172 91079488 XP_968513.1 480 1.7e-45 PREDICTED: probable peptidyl-tRNA hydrolase 2 [Tribolium castaneum]>gi|270003441|gb|EEZ99888.1| hypothetical protein TcasGA2_TC002672 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 O76387 270 1.5e-22 Probable peptidyl-tRNA hydrolase 2 OS=Caenorhabditis elegans GN=C24G6.8 PE=3 SV=1 PF01981 Peptidyl-tRNA hydrolase PTH2 -- -- GO:0004045 aminoacyl-tRNA hydrolase activity -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.13749 BP_3 3.75 0.34 827 91079488 XP_968513.1 238 1.4e-17 PREDICTED: probable peptidyl-tRNA hydrolase 2 [Tribolium castaneum]>gi|270003441|gb|EEZ99888.1| hypothetical protein TcasGA2_TC002672 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 Q60363 161 4.7e-10 Peptidyl-tRNA hydrolase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) GN=pth PE=1 SV=1 PF01981 Peptidyl-tRNA hydrolase PTH2 -- -- GO:0004045 aminoacyl-tRNA hydrolase activity -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.1375 BP_3 56.56 2.15 1561 642938789 XP_008199887.1 956 1.4e-100 PREDICTED: uncharacterized protein LOC657763 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13750 BP_3 40.97 1.96 1300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13751 BP_3 582.76 25.37 1399 646719797 KDR21783.1 645 1.5e-64 Protein SET [Zootermopsis nevadensis] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 596 2.9e-60 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF07352//PF00956 Bacteriophage Mu Gam like protein//Nucleosome assembly protein (NAP) GO:0006334//GO:0042262 nucleosome assembly//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.13752 BP_3 157.37 8.87 1147 646719797 KDR21783.1 645 1.2e-64 Protein SET [Zootermopsis nevadensis] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 596 2.4e-60 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF00956//PF02990 Nucleosome assembly protein (NAP)//Endomembrane protein 70 GO:0006334 nucleosome assembly -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.13753 BP_3 75.70 0.82 4727 642930553 XP_966739.2 2831 0.0e+00 PREDICTED: uncharacterized protein LOC655137 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13756 BP_3 26.69 0.41 3399 642923974 XP_008193948.1 435 8.0e-40 PREDICTED: hydrocephalus-inducing protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4G0P3 347 5.3e-31 Hydrocephalus-inducing protein homolog OS=Homo sapiens GN=HYDIN PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13757 BP_3 3.00 0.98 439 768409507 XP_011553200.1 441 2.1e-41 PREDICTED: fatty acid synthase-like, partial [Plutella xylostella] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 390 7.0e-37 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.13761 BP_3 28.34 1.26 1375 332373478 AEE61880.1 609 2.2e-60 unknown [Dendroctonus ponderosae]>gi|478263741|gb|ENN82044.1| hypothetical protein YQE_01619, partial [Dendroctonus ponderosae]>gi|546670972|gb|ERL83504.1| hypothetical protein D910_00535 [Dendroctonus ponderosae]>gi|546679616|gb|ERL90053.1| hypothetical protein D910_07409 [Dendroctonus ponderosae] -- -- -- -- -- K00949 thiN, TPK1, THI80 thiamine pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00949 Q9H3S4 406 3.1e-38 Thiamin pyrophosphokinase 1 OS=Homo sapiens GN=TPK1 PE=1 SV=1 PF04265//PF04263 Thiamin pyrophosphokinase, vitamin B1 binding domain//Thiamin pyrophosphokinase, catalytic domain GO:0009229//GO:0006772 thiamine diphosphate biosynthetic process//thiamine metabolic process GO:0030975//GO:0004788//GO:0005524 thiamine binding//thiamine diphosphokinase activity//ATP binding -- -- KOG3153 Thiamine pyrophosphokinase Cluster-8309.13762 BP_3 11.51 0.37 1786 546672343 ERL84251.1 222 2.1e-15 hypothetical protein D910_01632 [Dendroctonus ponderosae]>gi|546672458|gb|ERL84312.1| hypothetical protein D910_01724 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13766 BP_3 151.21 3.11 2637 817082989 XP_012264082.1 209 1.0e-13 PREDICTED: homeobox protein PKNOX2-like isoform X1 [Athalia rosae]>gi|817082991|ref|XP_012264083.1| PREDICTED: homeobox protein PKNOX2-like isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q2HJ84 195 1.7e-13 Homeobox protein PKNOX1 OS=Bos taurus GN=PKNOX1 PE=2 SV=1 PF00096//PF00046//PF07776//PF05920//PF13465//PF13912//PF00412//PF04810 Zinc finger, C2H2 type//Homeobox domain//Zinc-finger associated domain (zf-AD)//Homeobox KN domain//Zinc-finger double domain//C2H2-type zinc finger//LIM domain//Sec23/Sec24 zinc finger GO:0006355//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.13767 BP_3 58.81 1.07 2943 283969671 ADB54565.1 209 1.1e-13 PREP homeodomain-like protein [Schmidtea mediterranea] -- -- -- -- -- -- -- -- -- Q2HJ84 195 1.9e-13 Homeobox protein PKNOX1 OS=Bos taurus GN=PKNOX1 PE=2 SV=1 PF05920//PF07776//PF00096//PF00046//PF13912//PF04810//PF00412//PF13465 Homeobox KN domain//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Homeobox domain//C2H2-type zinc finger//Sec23/Sec24 zinc finger//LIM domain//Zinc-finger double domain GO:0006886//GO:0006888//GO:0006355 intracellular protein transport//ER to Golgi vesicle-mediated transport//regulation of transcription, DNA-templated GO:0003677//GO:0046872//GO:0008270 DNA binding//metal ion binding//zinc ion binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.13769 BP_3 249.17 3.52 3706 189234638 XP_975412.2 1912 4.7e-211 PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913950|ref|XP_008201227.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913953|ref|XP_008201229.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|270001630|gb|EEZ98077.1| hypothetical protein TcasGA2_TC000484 [Tribolium castaneum] -- -- -- -- -- K06229 SUFU suppressor of fused http://www.genome.jp/dbget-bin/www_bget?ko:K06229 Q9Z0P7 971 2.5e-103 Suppressor of fused homolog OS=Mus musculus GN=Sufu PE=1 SV=1 PF12470 Suppressor of Fused Gli/Ci N terminal binding domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13771 BP_3 182.83 2.54 3766 189234638 XP_975412.2 1924 1.9e-212 PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913950|ref|XP_008201227.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913953|ref|XP_008201229.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|270001630|gb|EEZ98077.1| hypothetical protein TcasGA2_TC000484 [Tribolium castaneum] -- -- -- -- -- K06229 SUFU suppressor of fused http://www.genome.jp/dbget-bin/www_bget?ko:K06229 Q9Z0P7 1269 7.1e-138 Suppressor of fused homolog OS=Mus musculus GN=Sufu PE=1 SV=1 PF12470 Suppressor of Fused Gli/Ci N terminal binding domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13772 BP_3 18.58 0.60 1782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13773 BP_3 81.00 5.84 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13775 BP_3 167.00 10.63 1049 642925222 XP_001811901.2 506 1.4e-48 PREDICTED: COMM domain-containing protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ76 217 1.9e-16 COMM domain-containing protein 3 OS=Bos taurus GN=COMMD3 PE=2 SV=1 PF05184//PF06350 Saposin-like type B, region 1//Hormone-sensitive lipase (HSL) N-terminus GO:0006629//GO:0008203//GO:0016042 lipid metabolic process//cholesterol metabolic process//lipid catabolic process GO:0016298 lipase activity -- -- -- -- Cluster-8309.13776 BP_3 120.00 4.27 1646 546681339 ERL91453.1 1660 3.5e-182 hypothetical protein D910_08783 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96CB9 521 1.7e-51 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 PE=1 SV=2 PF01189//PF01728 16S rRNA methyltransferase RsmF//FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2198 tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily Cluster-8309.1378 BP_3 1168.68 65.48 1152 91091646 XP_970895.1 249 1.0e-18 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000889|gb|EEZ97336.1| hypothetical protein TcasGA2_TC011148 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 179 5.4e-12 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.13780 BP_3 116.92 2.35 2686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00616 GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity -- -- -- -- -- -- Cluster-8309.13781 BP_3 16.00 0.83 1221 668447823 KFB37563.1 164 7.6e-09 hypothetical protein ZHAS_00004799 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.13782 BP_3 216.08 4.87 2432 189237885 XP_975345.2 2844 0.0e+00 PREDICTED: conserved oligomeric Golgi complex subunit 4 [Tribolium castaneum]>gi|270006703|gb|EFA03151.1| hypothetical protein TcasGA2_TC013064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95TN4 1685 2.7e-186 Conserved oligomeric Golgi complex subunit 4 OS=Drosophila melanogaster GN=CG7456 PE=1 SV=1 PF07393 Exocyst complex component Sec10 GO:0006887//GO:0048278 exocytosis//vesicle docking -- -- GO:0005737 cytoplasm KOG0412 Golgi transport complex COD1 protein Cluster-8309.13783 BP_3 38.43 0.78 2652 189237885 XP_975345.2 2805 0.0e+00 PREDICTED: conserved oligomeric Golgi complex subunit 4 [Tribolium castaneum]>gi|270006703|gb|EFA03151.1| hypothetical protein TcasGA2_TC013064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95TN4 1651 2.5e-182 Conserved oligomeric Golgi complex subunit 4 OS=Drosophila melanogaster GN=CG7456 PE=1 SV=1 -- -- GO:0006887//GO:0048278 exocytosis//vesicle docking -- -- GO:0005737 cytoplasm KOG0412 Golgi transport complex COD1 protein Cluster-8309.13784 BP_3 1.00 0.51 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13786 BP_3 20.12 0.37 2907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13787 BP_3 95.00 4.94 1218 478255833 ENN76041.1 506 1.7e-48 hypothetical protein YQE_07414, partial [Dendroctonus ponderosae]>gi|546680472|gb|ERL90738.1| hypothetical protein D910_08085 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VKD7 179 5.7e-12 Mitochondrial cardiolipin hydrolase OS=Drosophila melanogaster GN=zuc PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13788 BP_3 10.93 0.76 985 642931096 XP_974337.3 327 7.7e-28 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWU1 197 3.8e-14 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089//PF12937 Trypsin//F-box-like GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.1379 BP_3 35.00 2.78 898 744582533 XP_010984398.1 194 1.9e-12 PREDICTED: histone H3.1 [Camelus dromedarius] -- -- -- -- -- K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P90543 191 1.7e-13 Histone H3 OS=Euplotes crassus PE=3 SV=3 PF00125//PF02969 Core histone H2A/H2B/H3/H4//TATA box binding protein associated factor (TAF) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.13790 BP_3 8.58 0.48 1152 642931096 XP_974337.3 278 4.4e-22 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09614 CORIN corin http://www.genome.jp/dbget-bin/www_bget?ko:K09614 Q9Z319 198 3.4e-14 Atrial natriuretic peptide-converting enzyme OS=Mus musculus GN=Corin PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.13791 BP_3 64.90 1.76 2066 642931094 XP_008196209.1 460 6.1e-43 PREDICTED: serine protease persephone-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K09751 TMPRSS11B transmembrane protease, serine 11B http://www.genome.jp/dbget-bin/www_bget?ko:K09751 Q9VWU1 327 6.7e-29 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00646//PF00089//PF12937 F-box domain//Trypsin//F-box-like GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.13792 BP_3 9.52 0.37 1528 546675013 ERL86276.1 286 6.8e-23 hypothetical protein D910_03685 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01061//PF01990 ABC-2 type transporter//ATP synthase (F/14-kDa) subunit GO:0034220 ion transmembrane transport -- -- GO:0016020 membrane -- -- Cluster-8309.13793 BP_3 7.00 0.93 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13797 BP_3 1.00 12.70 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1380 BP_3 10.01 0.78 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02444 Hepatitis E virus ORF-2 (Putative capsid protein) -- -- -- -- GO:0030430 host cell cytoplasm -- -- Cluster-8309.13802 BP_3 10.72 0.32 1904 642927183 XP_008195170.1 1496 4.2e-163 PREDICTED: synaptic vesicle glycoprotein 2B-like isoform X2 [Tribolium castaneum]>gi|642927185|ref|XP_008195171.1| PREDICTED: synaptic vesicle glycoprotein 2B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7L1I2 274 8.6e-23 Synaptic vesicle glycoprotein 2B OS=Homo sapiens GN=SV2B PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.13805 BP_3 2799.88 49.56 3015 270001354 EEZ97801.1 3487 0.0e+00 hypothetical protein TcasGA2_TC000163 [Tribolium castaneum] 817183960 XM_012423831.1 511 0 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13806 BP_3 5648.35 101.23 2981 270001354 EEZ97801.1 3487 0.0e+00 hypothetical protein TcasGA2_TC000163 [Tribolium castaneum] 817183960 XM_012423831.1 511 0 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13807 BP_3 262.06 4.56 3063 270001354 EEZ97801.1 3487 0.0e+00 hypothetical protein TcasGA2_TC000163 [Tribolium castaneum] 817183960 XM_012423831.1 511 0 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1381 BP_3 24.00 0.87 1624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03493 Calcium-activated BK potassium channel alpha subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.13810 BP_3 35.71 1.37 1548 91084853 XP_967519.1 230 2.2e-16 PREDICTED: uncharacterized protein LOC655864 [Tribolium castaneum]>gi|270008971|gb|EFA05419.1| hypothetical protein TcasGA2_TC015595 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13811 BP_3 24.51 2.10 854 749732921 XP_011142956.1 305 2.4e-25 PREDICTED: uncharacterized protein LOC105185281 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13812 BP_3 115.49 12.34 743 478253284 ENN73653.1 347 2.8e-30 hypothetical protein YQE_09731, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13814 BP_3 5.04 0.52 763 751237885 XP_011172858.1 248 8.6e-19 PREDICTED: uncharacterized protein LOC105205238 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13817 BP_3 42.35 0.85 2687 546683622 ERL93410.1 923 1.6e-96 hypothetical protein D910_10702 [Dendroctonus ponderosae] 676494731 XM_009068407.1 36 1.18085e-06 Lottia gigantea hypothetical protein mRNA K01057 PGLS, pgl, devB 6-phosphogluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01057 P85971 532 1.5e-52 6-phosphogluconolactonase OS=Rattus norvegicus GN=Pgls PE=1 SV=1 PF09771//PF01182 Transmembrane protein 188//Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase GO:0005975//GO:0035307 carbohydrate metabolic process//positive regulation of protein dephosphorylation -- -- GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.13820 BP_3 47.59 0.82 3086 91083833 XP_973697.1 435 7.3e-40 PREDICTED: endocuticle structural glycoprotein SgAbd-8 [Tribolium castaneum]>gi|270006770|gb|EFA03218.1| hypothetical protein TcasGA2_TC013138 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 219 3.3e-16 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.13822 BP_3 548.40 6.96 4090 91094617 XP_968941.1 495 1.1e-46 PREDICTED: NEDD4-binding protein 2 [Tribolium castaneum]>gi|270016434|gb|EFA12880.1| hypothetical protein TcasGA2_TC011558 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UW6 202 4.1e-14 NEDD4-binding protein 2 OS=Homo sapiens GN=N4BP2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2401 Predicted MutS-related protein involved in mismatch repair Cluster-8309.13826 BP_3 12.58 0.57 1356 332374418 AEE62350.1 554 5.1e-54 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01939 262 1.5e-21 Protein misato OS=Drosophila melanogaster GN=mst PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2530 Members of tubulin/FtsZ family Cluster-8309.13827 BP_3 86.93 2.15 2239 478259929 ENN79731.1 1241 1.8e-133 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U2U7 606 3.2e-61 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF09243//PF12326//PF02285 Mitochondrial small ribosomal subunit Rsm22//N-glycosylation protein//Cytochrome oxidase c subunit VIII GO:0015992//GO:0034599//GO:0006412//GO:0006123 proton transport//cellular response to oxidative stress//translation//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277//GO:0005789 respiratory chain complex IV//endoplasmic reticulum membrane KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.13828 BP_3 39.11 0.91 2371 642931113 XP_008201666.1 300 2.5e-24 PREDICTED: autism susceptibility gene 2 protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13830 BP_3 3.00 0.72 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13831 BP_3 28.00 1.40 1259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13832 BP_3 3.00 0.78 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13834 BP_3 39.00 0.81 2621 642930505 XP_008196432.1 2088 1.3e-231 PREDICTED: uncharacterized protein LOC663901 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03002 Somatostatin/Cortistatin family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.13837 BP_3 4.59 0.33 957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13838 BP_3 131.01 6.28 1298 91078694 XP_971269.1 963 1.8e-101 PREDICTED: mitochondrial inner membrane protease ATP23 homolog [Tribolium castaneum]>gi|270003760|gb|EFA00208.1| hypothetical protein TcasGA2_TC003033 [Tribolium castaneum] -- -- -- -- -- K18156 ATP23, XRCC6BP1 mitochondrial inner membrane protease ATP23 http://www.genome.jp/dbget-bin/www_bget?ko:K18156 A4IGF3 406 2.9e-38 Mitochondrial inner membrane protease ATP23 homolog OS=Danio rerio GN=zgc:162885 PE=2 SV=1 PF09768 Peptidase M76 family -- -- GO:0004222 metalloendopeptidase activity -- -- KOG3314 Ku70-binding protein Cluster-8309.13840 BP_3 266.00 4.67 3039 332373326 AEE61804.1 1238 5.5e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14829 IPI3 pre-rRNA-processing protein IPI3 http://www.genome.jp/dbget-bin/www_bget?ko:K14829 Q68EI0 554 4.7e-55 WD repeat-containing protein 18 OS=Danio rerio GN=wdr18 PE=2 SV=1 PF00400//PF03178 WD domain, G-beta repeat//CPSF A subunit region -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus KOG0646 WD40 repeat protein Cluster-8309.13841 BP_3 3.00 2.25 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1385 BP_3 2.00 1.02 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13853 BP_3 1.52 0.40 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05149 Paraflagellar rod protein -- -- GO:0005516 calmodulin binding GO:0031514 motile cilium -- -- Cluster-8309.13855 BP_3 7.00 1.20 574 642914858 XP_008195062.1 166 2.1e-09 PREDICTED: uncharacterized protein LOC103313485 [Tribolium castaneum]>gi|270002307|gb|EEZ98754.1| hypothetical protein TcasGA2_TC001318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03033 Glycosyltransferase family 28 N-terminal domain GO:0030259//GO:0005975 lipid glycosylation//carbohydrate metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.13856 BP_3 202.58 25.28 678 91089477 XP_969208.1 279 2.0e-22 PREDICTED: zinc finger HIT domain-containing protein 3 [Tribolium castaneum]>gi|270012577|gb|EFA09025.1| hypothetical protein TcasGA2_TC006734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQK1 181 1.9e-12 Zinc finger HIT domain-containing protein 3 OS=Mus musculus GN=Znhit3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2857 Predicted MYND Zn-finger protein/hormone receptor interactor Cluster-8309.13857 BP_3 400.56 10.05 2213 91090592 XP_972768.1 1921 2.5e-212 PREDICTED: RNA polymerase I-specific transcription initiation factor RRN3 [Tribolium castaneum] -- -- -- -- -- K15216 RRN3, TIFIA RNA polymerase I-specific transcription initiation factor RRN3 http://www.genome.jp/dbget-bin/www_bget?ko:K15216 B2RS91 878 9.2e-93 RNA polymerase I-specific transcription initiation factor RRN3 OS=Mus musculus GN=Rrn3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2434 RNA polymerase I transcription factor Cluster-8309.13862 BP_3 8.00 0.38 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13865 BP_3 30.07 1.31 1397 642914590 XP_008190277.1 280 3.1e-22 PREDICTED: venom prothrombin activator trocarin-D-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05589 137 4.9e-07 Urokinase-type plasminogen activator OS=Bos taurus GN=PLAU PE=2 SV=1 PF15220 Hypoxia-inducible lipid droplet-associated GO:0008284//GO:0010884//GO:0001819 positive regulation of cell proliferation//positive regulation of lipid storage//positive regulation of cytokine production -- -- -- -- -- -- Cluster-8309.13868 BP_3 7.08 0.52 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.13869 BP_3 180.92 7.88 1399 546684929 ERL94511.1 181 9.3e-11 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.13870 BP_3 206.96 5.35 2155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13873 BP_3 60.29 2.57 1424 91094905 XP_973449.1 1340 3.8e-145 PREDICTED: F-box/SPRY domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270006590|gb|EFA03038.1| hypothetical protein TcasGA2_TC010464 [Tribolium castaneum] 242007554 XM_002424560.1 192 1.17951e-93 Pediculus humanus corporis F-box/SPRY-domain protein, putative, mRNA K10319 FBXO45 F-box protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K10319 B4HQ29 1187 8.7e-129 F-box/SPRY domain-containing protein 1 OS=Drosophila sechellia GN=Fsn PE=3 SV=1 PF00646//PF12937//PF00622 F-box domain//F-box-like//SPRY domain -- -- GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.13874 BP_3 1091.72 8.95 6173 642932046 XP_008196836.1 832 1.3e-85 PREDICTED: uncharacterized protein LOC103313971 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80VL1 172 1.9e-10 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF04277//PF15802 Oxaloacetate decarboxylase, gamma chain//DDB1- and CUL4-associated factor 17 GO:0006814//GO:0071436//GO:0006090//GO:0016567//GO:0006560//GO:0006525 sodium ion transport//sodium ion export//pyruvate metabolic process//protein ubiquitination//proline metabolic process//arginine metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.13876 BP_3 37.64 1.39 1597 817053121 XP_012260281.1 1815 3.6e-200 PREDICTED: exportin-7 isoform X1 [Athalia rosae] 683938964 XM_009099819.1 215 2.17295e-106 PREDICTED: Serinus canaria exportin 7 (XPO7), partial mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 1497 1.1e-164 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.13877 BP_3 46.48 1.01 2505 189235509 XP_969871.2 1824 5.1e-201 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 659 2.6e-67 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3621 WD40 repeat-containing protein Cluster-8309.13880 BP_3 25.70 1.13 1386 642931096 XP_974337.3 420 1.8e-38 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q9VWU1 278 2.2e-23 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.13882 BP_3 135.08 5.59 1457 642931096 XP_974337.3 538 3.9e-52 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09751 TMPRSS11B transmembrane protease, serine 11B http://www.genome.jp/dbget-bin/www_bget?ko:K09751 Q9VWU1 365 1.8e-33 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089//PF12937 Trypsin//F-box-like GO:0006508 proteolysis GO:0005515//GO:0004252 protein binding//serine-type endopeptidase activity -- -- -- -- Cluster-8309.13884 BP_3 3.85 0.37 800 242002666 XP_002435976.1 518 4.5e-50 RNA polymerase II proteinral transcription factor BTF3, putative [Ixodes scapularis]>gi|215499312|gb|EEC08806.1| RNA polymerase II proteinral transcription factor BTF3, putative [Ixodes scapularis] 242002665 XM_002435931.1 119 2.47651e-53 Ixodes scapularis RNA polymerase II proteinral transcription factor BTF3, putative, mRNA K01527 EGD1, BTF3 nascent polypeptide-associated complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01527 Q6PC91 493 1.5e-48 Transcription factor BTF3 homolog 4 OS=Danio rerio GN=btf3l4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2240 RNA polymerase II general transcription factor BTF3 and related proteins Cluster-8309.13887 BP_3 76.38 3.53 1334 270013563 EFA10011.1 471 2.1e-44 hypothetical protein TcasGA2_TC012182 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7G4 310 4.0e-27 Protein FAM45A OS=Danio rerio GN=fam45a PE=2 SV=1 PF03495 Clostridial binary toxin B/anthrax toxin PA GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.1389 BP_3 2.00 0.32 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13890 BP_3 28582.36 584.92 2647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13891 BP_3 11.00 1.30 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02386 Cation transport protein GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-8309.13892 BP_3 89.37 1.47 3231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13893 BP_3 3.00 0.80 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13899 BP_3 8.03 0.33 1460 478253336 ENN73697.1 402 2.3e-36 hypothetical protein YQE_09694, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0W2W6 229 1.1e-17 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.1390 BP_3 7.00 0.50 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13902 BP_3 122.50 2.25 2916 642934942 XP_008195881.1 782 4.0e-80 PREDICTED: RCC1 domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K07944 ARL3 ADP-ribosylation factor-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07944 Q8QHI3 589 3.9e-59 ADP-ribosylation factor-like protein 3 OS=Xenopus laevis GN=arl3 PE=2 SV=1 PF01926//PF08477//PF02421//PF00025//PF00004//PF00005//PF03785//PF00071//PF04670//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA)//ABC transporter//Peptidase family C25, C terminal ig-like domain//Ras family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007165//GO:0007264//GO:0015684//GO:0007186//GO:0006508 signal transduction//small GTPase mediated signal transduction//ferrous iron transport//G-protein coupled receptor signaling pathway//proteolysis GO:0003924//GO:0015093//GO:0005524//GO:0031683//GO:0008233//GO:0005525//GO:0004871//GO:0019001//GO:0016887 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//G-protein beta/gamma-subunit complex binding//peptidase activity//GTP binding//signal transducer activity//guanyl nucleotide binding//ATPase activity GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.13903 BP_3 85.50 2.41 2003 642934942 XP_008195881.1 782 2.7e-80 PREDICTED: RCC1 domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NED2 334 1.0e-29 RCC1 domain-containing protein 1 OS=Homo sapiens GN=RCCD1 PE=1 SV=1 PF03785 Peptidase family C25, C terminal ig-like domain GO:0006508 proteolysis GO:0008233 peptidase activity -- -- KOG1426 FOG: RCC1 domain Cluster-8309.13909 BP_3 2.00 1.15 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13910 BP_3 5.00 0.31 1074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13914 BP_3 11.16 0.54 1288 478258345 ENN78464.1 670 1.7e-67 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] 462363670 APGK01028279.1 38 4.31597e-08 Dendroctonus ponderosae Seq01028289, whole genome shotgun sequence -- -- -- -- P91660 432 2.8e-41 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF00664//PF02723 Protein of unknown function, DUF258//ABC transporter//ABC transporter transmembrane region//Non-structural protein NS3/Small envelope protein E GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.13918 BP_3 7.66 0.42 1170 332372700 AEE61492.1 807 2.0e-83 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7QBJ0 510 2.3e-50 UPF0483 protein AGAP003155 OS=Anopheles gambiae GN=AGAP003155 PE=3 SV=3 PF02230 Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- KOG2551 Phospholipase/carboxyhydrolase Cluster-8309.1392 BP_3 10.00 1.26 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13920 BP_3 25.34 0.43 3164 546683292 ERL93124.1 324 5.5e-27 hypothetical protein D910_10425, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P42704 163 1.1e-09 Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens GN=LRPPRC PE=1 SV=3 PF04369//PF13181//PF13414//PF13176//PF03002//PF08686//PF00515//PF03973 Lactococcin-like family//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Somatostatin/Cortistatin family//PLAC (protease and lacunin) domain//Tetratricopeptide repeat//Triabin GO:0030682//GO:0042742//GO:0007165 evasion or tolerance of host defense response//defense response to bacterium//signal transduction GO:0005515//GO:0008233//GO:0005179 protein binding//peptidase activity//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.13921 BP_3 83.82 3.92 1322 10835071 NP_004346.1 1174 6.3e-126 HLA class II histocompatibility antigen gamma chain isoform b [Homo sapiens]>gi|32131|emb|CAA25192.1| unnamed protein product [Homo sapiens]>gi|386790|gb|AAA36033.1| cell surface glycoprotein, partial [Homo sapiens]>gi|17511740|gb|AAH18726.1| CD74 molecule, major histocompatibility complex, class II invariant chain [Homo sapiens]>gi|54695880|gb|AAV38312.1| CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) [Homo sapiens]>gi|61356428|gb|AAX41244.1| CD74 antigen [synthetic construct]>gi|119582132|gb|EAW61728.1| CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), isoform CRA_b [Homo sapiens]>gi|119582134|gb|EAW61730.1| CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), isoform CRA_b [Homo sapiens]>gi|123982371|gb|ABM82931.1| CD74 molecule, major histocompatibility complex, class II invariant chain [synthetic construct]>gi|123997037|gb|ABM86120.1| CD74 molecule, major histocompatibility complex, class II invariant chain [synthetic construct]>gi|158257584|dbj|BAF84765.1| unnamed protein product [Homo sapiens]>gi|307684782|dbj|BAJ20431.1| CD74 molecule, major histocompatibility complex, class II invariant chain [synthetic construct]>gi|649099054|gb|AIC48463.1| CD74, partial [synthetic construct] 343403784 NM_004355.3 1298 0 Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 2, mRNA K06505 CD74, DHLAG CD74 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06505 P04233 1052 3.6e-113 HLA class II histocompatibility antigen gamma chain OS=Homo sapiens GN=CD74 PE=1 SV=3 PF08831//PF09307 Class II MHC-associated invariant chain trimerisation domain//CLIP, MHC2 interacting GO:0001961//GO:0001516//GO:0019883//GO:0045582//GO:0048146//GO:0060907//GO:0043518//GO:0000187//GO:0002830//GO:0006955//GO:0006952//GO:0006886//GO:0007165//GO:0070374//GO:0045581//GO:0035691//GO:0050731//GO:0002906//GO:0045059//GO:0030890//GO:0045060//GO:0019886//GO:0019882//GO:0051085//GO:0016064//GO:2000343//GO:0090023//GO:0002606//GO:0002792//GO:0043030//GO:0006461 positive regulation of cytokine-mediated signaling pathway//prostaglandin biosynthetic process//antigen processing and presentation of endogenous antigen//positive regulation of T cell differentiation//positive regulation of fibroblast proliferation//positive regulation of macrophage cytokine production//negative regulation of DNA damage response, signal transduction by p53 class mediator//activation of MAPK activity//positive regulation of type 2 immune response//immune response//defense response//intracellular protein transport//signal transduction//positive regulation of ERK1 and ERK2 cascade//negative regulation of T cell differentiation//macrophage migration inhibitory factor signaling pathway//positive regulation of peptidyl-tyrosine phosphorylation//negative regulation of mature B cell apoptotic process//positive thymic T cell selection//positive regulation of B cell proliferation//negative thymic T cell selection//antigen processing and presentation of exogenous peptide antigen via MHC class II//antigen processing and presentation//chaperone mediated protein folding requiring cofactor//immunoglobulin mediated immune response//positive regulation of chemokine (C-X-C motif) ligand 2 production//positive regulation of neutrophil chemotaxis//positive regulation of dendritic cell antigen processing and presentation//negative regulation of peptide secretion//regulation of macrophage activation//protein complex assembly GO:0042802//GO:0035718//GO:0042289//GO:0004896//GO:0001540//GO:0050998 identical protein binding//macrophage migration inhibitory factor binding//MHC class II protein binding//cytokine receptor activity//beta-amyloid binding//nitric-oxide synthase binding GO:0030669//GO:0016020//GO:0042613//GO:0005765//GO:0043202//GO:0032588//GO:0012507//GO:0000139//GO:0035693//GO:0071556//GO:0035692//GO:0005771//GO:0009897 clathrin-coated endocytic vesicle membrane//membrane//MHC class II protein complex//lysosomal membrane//lysosomal lumen//trans-Golgi network membrane//ER to Golgi transport vesicle membrane//Golgi membrane//NOS2-CD74 complex//integral component of lumenal side of endoplasmic reticulum membrane//macrophage migration inhibitory factor receptor complex//multivesicular body//external side of plasma membrane -- -- Cluster-8309.13925 BP_3 11.00 0.97 840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13926 BP_3 16.55 0.80 1290 642919285 XP_008191809.1 204 1.9e-13 PREDICTED: leucine-rich repeat-containing protein 63-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13927 BP_3 119.18 0.92 6555 283046724 NP_001164308.1 351 8.5e-30 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 275 2.3e-22 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF00096//PF04988//PF09153//PF07535//PF00520//PF13606 Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//Domain of unknown function (DUF1938)//DBF zinc finger//Ion transport protein//Ankyrin repeat GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0003677//GO:0005515//GO:0008270//GO:0005216//GO:0003676//GO:0046872 DNA binding//protein binding//zinc ion binding//ion channel activity//nucleic acid binding//metal ion binding GO:0005634//GO:0016020//GO:0005737 nucleus//membrane//cytoplasm -- -- Cluster-8309.13929 BP_3 15.93 0.48 1898 189240952 XP_971597.2 1295 8.5e-140 PREDICTED: methionine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q9VFL5 931 5.6e-99 Methionine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-met PE=2 SV=2 PF08264//PF09334//PF00133 Anticodon-binding domain of tRNA//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V) GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity -- -- KOG0436 Methionyl-tRNA synthetase Cluster-8309.13932 BP_3 13.00 2.25 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13933 BP_3 28.78 1.14 1510 821114442 XP_012381239.1 200 6.3e-13 PREDICTED: synaptonemal complex protein 2 isoform X1 [Dasypus novemcinctus] -- -- -- -- -- -- -- -- -- Q9BX26 184 1.9e-12 Synaptonemal complex protein 2 OS=Homo sapiens GN=SYCP2 PE=2 SV=2 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.13941 BP_3 27.12 3.60 655 546680624 ERL90862.1 229 1.2e-16 hypothetical protein D910_08207 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.13944 BP_3 4.00 0.51 667 198461141 XP_002135891.1 279 1.9e-22 GA22538 [Drosophila pseudoobscura pseudoobscura]>gi|198139679|gb|EDY70778.1| GA22538 [Drosophila pseudoobscura pseudoobscura] -- -- -- -- -- -- -- -- -- Q03272 161 3.8e-10 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 4 (Fragment) OS=Nasonia vitripennis PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13945 BP_3 20.00 0.54 2074 270008217 EFA04665.1 1313 7.6e-142 cytochrome P450-like protein [Tribolium castaneum] 194753078 XM_001958810.1 37 2.52605e-07 Drosophila ananassae GF12357 (Dana\GF12357), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 898 4.1e-95 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.13949 BP_3 96.93 3.82 1514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06337 DUSP domain GO:0016579//GO:0006508 protein deubiquitination//proteolysis GO:0004843 ubiquitin-specific protease activity -- -- -- -- Cluster-8309.13950 BP_3 4.00 1.38 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13951 BP_3 69.23 8.73 674 642932768 XP_008196975.1 286 3.0e-23 PREDICTED: uncharacterized protein LOC662560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13953 BP_3 48.03 1.81 1572 642919030 XP_008191704.1 1146 1.3e-122 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 194893660 XM_001977880.1 36 6.84849e-07 Drosophila erecta GG19306 (Dere\GG19306), mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 -- -- -- -- PF10458//PF12920 Valyl tRNA synthetase tRNA binding arm//TcdA/TcdB pore forming domain GO:0009098//GO:0009097//GO:0009405//GO:0006438//GO:0009099 leucine biosynthetic process//isoleucine biosynthetic process//pathogenesis//valyl-tRNA aminoacylation//valine biosynthetic process GO:0005524//GO:0000166//GO:0004832 ATP binding//nucleotide binding//valine-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.13958 BP_3 197.43 2.13 4768 91086801 XP_973474.1 2037 1.9e-225 PREDICTED: transmembrane protein 8A [Tribolium castaneum]>gi|642929011|ref|XP_008195653.1| PREDICTED: transmembrane protein 8A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QLK4 427 3.9e-40 Transmembrane protein 8B OS=Bos taurus GN=TMEM8B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13960 BP_3 1.00 0.86 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13961 BP_3 684.13 17.44 2183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane -- -- Cluster-8309.13969 BP_3 15.00 0.37 2250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13970 BP_3 22.53 1.85 879 642928748 XP_008199766.1 199 4.8e-13 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.13979 BP_3 92.43 1.49 3282 642927677 XP_008196502.1 557 5.5e-54 PREDICTED: protein quiver [Tribolium castaneum] 759079745 XM_011351395.1 136 3.71912e-62 PREDICTED: Cerapachys biroi protein quiver (LOC105286442), transcript variant X2, mRNA -- -- -- -- B3NSF6 523 2.0e-51 Protein quiver OS=Drosophila erecta GN=qvr PE=3 SV=1 PF17064//PF01064 Sleepless protein//Activin types I and II receptor domain GO:0030431//GO:1903818//GO:0032222//GO:0016310//GO:0009069//GO:0007178 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic//phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.1398 BP_3 16.21 0.31 2814 357611789 EHJ67650.1 996 5.9e-105 hypothetical protein KGM_11902 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062 Clc-like -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.13994 BP_3 3.00 0.42 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13995 BP_3 51.98 1.33 2174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.140 BP_3 161.01 8.81 1173 91086171 XP_970531.1 570 6.1e-56 PREDICTED: uncharacterized protein LOC659106 [Tribolium castaneum]>gi|270009881|gb|EFA06329.1| hypothetical protein TcasGA2_TC009200 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14000 BP_3 19.13 2.84 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14002 BP_3 368.52 23.80 1038 642910499 XP_008200240.1 1139 5.7e-122 PREDICTED: G protein alpha i subunit [Tribolium castaneum]>gi|270014387|gb|EFA10835.1| hypothetical protein TcasGA2_TC001612 [Tribolium castaneum] 676443682 XM_009051945.1 104 7.07619e-45 Lottia gigantea hypothetical protein partial mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 P20353 986 1.3e-105 G protein alpha i subunit OS=Drosophila melanogaster GN=Galphai PE=1 SV=2 PF08477//PF01580//PF00025//PF04670//PF00503 Ras of Complex, Roc, domain of DAPkinase//FtsK/SpoIIIE family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007165//GO:0007264//GO:0007186 signal transduction//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0005524//GO:0003677//GO:0031683//GO:0005525//GO:0000166//GO:0004871//GO:0019001 GTPase activity//ATP binding//DNA binding//G-protein beta/gamma-subunit complex binding//GTP binding//nucleotide binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.14003 BP_3 142.21 3.94 2031 270006842 EFA03290.1 364 8.2e-32 hypothetical protein TcasGA2_TC013230 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88900 196 1.0e-13 Growth factor receptor-bound protein 14 OS=Rattus norvegicus GN=Grb14 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14005 BP_3 20.00 1.50 935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14011 BP_3 119.75 0.84 7185 642935862 XP_008198202.1 2012 2.3e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 8.78747e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 3.7e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF13176//PF13414//PF13371//PF00515//PF13374//PF00638//PF02064//PF13181 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//RanBP1 domain//MAS20 protein import receptor//Tetratricopeptide repeat GO:0046907//GO:0006886//GO:0006605 intracellular transport//intracellular protein transport//protein targeting GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.14012 BP_3 21.00 0.76 1624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.14013 BP_3 6.41 1.17 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14017 BP_3 43.00 1.47 1702 758375864 AJO70184.1 1476 7.8e-161 sodium-potassium ATPase beta [Cherax cainii] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 P25169 761 2.6e-79 Sodium/potassium-transporting ATPase subunit beta OS=Artemia franciscana PE=2 SV=1 PF02140//PF00287 Galactose binding lectin domain//Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport GO:0030246 carbohydrate binding GO:0005890 sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.14022 BP_3 67.92 1.32 2778 642915531 XP_008190654.1 1985 1.2e-219 PREDICTED: 1-acylglycerophosphocholine O-acyltransferase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13510 LPCAT1_2 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13510 Q0KHU5 1061 6.9e-114 1-acylglycerophosphocholine O-acyltransferase 1 OS=Drosophila melanogaster GN=CG32699 PE=2 SV=1 PF13499//PF13833//PF00036//PF13405//PF01553 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Acyltransferase GO:0008152 metabolic process GO:0016746//GO:0005509 transferase activity, transferring acyl groups//calcium ion binding -- -- KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.14023 BP_3 69.13 1.34 2778 642915529 XP_008190653.1 1975 1.7e-218 PREDICTED: 1-acylglycerophosphocholine O-acyltransferase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13510 LPCAT1_2 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13510 Q0KHU5 1024 1.4e-109 1-acylglycerophosphocholine O-acyltransferase 1 OS=Drosophila melanogaster GN=CG32699 PE=2 SV=1 PF01553//PF13833//PF13405//PF00036//PF13499 Acyltransferase//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair GO:0008152 metabolic process GO:0016746//GO:0005509 transferase activity, transferring acyl groups//calcium ion binding -- -- KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.14028 BP_3 8.45 0.51 1089 225543488 NP_001139390.1 455 1.2e-42 phospholipase A2B precursor [Tribolium castaneum]>gi|224383699|gb|ACN42748.1| phospholipase A2B [Tribolium castaneum]>gi|270011520|gb|EFA07968.1| hypothetical protein TcasGA2_TC005550 [Tribolium castaneum] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P16354 228 1.1e-17 Phospholipase A2 isozymes PA3A/PA3B/PA5 OS=Heloderma suspectum PE=1 SV=3 -- -- GO:0009395//GO:0016042 phospholipid catabolic process//lipid catabolic process GO:0004623//GO:0005509 phospholipase A2 activity//calcium ion binding -- -- -- -- Cluster-8309.14029 BP_3 18.00 0.50 2013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1403 BP_3 33.00 0.44 3879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14035 BP_3 5.00 0.81 589 641672832 XP_008186080.1 158 1.8e-08 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q14119 137 2.0e-07 Vascular endothelial zinc finger 1 OS=Homo sapiens GN=VEZF1 PE=1 SV=2 PF00096//PF13465//PF02892//PF13912//PF00643 Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//B-box zinc finger -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.14039 BP_3 4.00 0.57 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14047 BP_3 5.00 0.49 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.1405 BP_3 11.00 0.36 1774 795010889 XP_011869582.1 939 1.5e-98 PREDICTED: uncharacterized protein LOC105562976 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- P34457 329 3.4e-29 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF02772//PF00665 S-adenosylmethionine synthetase, central domain//Integrase core domain GO:0006556//GO:0015074//GO:0006555 S-adenosylmethionine biosynthetic process//DNA integration//methionine metabolic process GO:0004478 methionine adenosyltransferase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.14053 BP_3 19.00 0.74 1533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05770 Inositol 1, 3, 4-trisphosphate 5/6-kinase GO:0032957 inositol trisphosphate metabolic process GO:0000287//GO:0047325//GO:0052725//GO:0052726//GO:0005524 magnesium ion binding//inositol tetrakisphosphate 1-kinase activity//inositol-1,3,4-trisphosphate 6-kinase activity//inositol-1,3,4-trisphosphate 5-kinase activity//ATP binding GO:0005622 intracellular -- -- Cluster-8309.14054 BP_3 34.00 1.56 1341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14056 BP_3 16.00 0.58 1616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14057 BP_3 77.19 1.59 2632 189234553 XP_973928.2 900 7.4e-94 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V9A8 291 1.3e-24 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14058 BP_3 297.10 11.77 1508 283046838 NP_001164362.1 1764 2.8e-194 pleiohomeotic [Tribolium castaneum]>gi|270009286|gb|EFA05734.1| pleiohomeotic [Tribolium castaneum] 462309609 APGK01047630.1 135 6.07194e-62 Dendroctonus ponderosae Seq01047640, whole genome shotgun sequence K09201 YY transcription factor YY http://www.genome.jp/dbget-bin/www_bget?ko:K09201 P25490 903 7.9e-96 Transcriptional repressor protein YY1 OS=Homo sapiens GN=YY1 PE=1 SV=2 PF16622//PF13465//PF02176//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.14060 BP_3 16.00 0.53 1745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0055114//GO:0046487//GO:0009396 oxidation-reduction process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- -- -- Cluster-8309.14062 BP_3 4.00 1.16 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14064 BP_3 60.83 3.16 1221 91077544 XP_971725.1 1277 6.6e-138 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X1 [Tribolium castaneum] 642914119 XM_008203330.1 346 2.48288e-179 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q12923 206 4.2e-15 Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2 PF13180//PF00595//PF05777 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) GO:0007617 mating behavior GO:0005515 protein binding GO:0005576 extracellular region -- -- Cluster-8309.14068 BP_3 8.06 0.70 848 642931092 XP_008196207.1 354 4.9e-31 PREDICTED: ATP-dependent RNA helicase DDX42 [Tribolium castaneum]>gi|270012072|gb|EFA08520.1| hypothetical protein TcasGA2_TC006173 [Tribolium castaneum] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q86XP3 280 7.7e-24 ATP-dependent RNA helicase DDX42 OS=Homo sapiens GN=DDX42 PE=1 SV=1 -- -- -- -- GO:0008026//GO:0005524//GO:0003676 ATP-dependent helicase activity//ATP binding//nucleic acid binding -- -- KOG0339 ATP-dependent RNA helicase Cluster-8309.1407 BP_3 3.00 0.61 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14070 BP_3 2.00 0.51 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14072 BP_3 11.00 0.58 1213 478257049 ENN77213.1 199 6.6e-13 hypothetical protein YQE_06350, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14073 BP_3 10.00 3.68 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14075 BP_3 16.78 1.29 919 675382556 KFM75453.1 392 2.1e-35 Transposable element Tcb1 transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q04202 251 1.9e-20 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14076 BP_3 23.00 2.06 829 828217980 XP_012560822.1 309 8.0e-26 PREDICTED: uncharacterized protein LOC105846528 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04545//PF00196//PF08281//PF08220//PF01498//PF01316//PF01418//PF01527//PF13404 Sigma-70, region 4//Bacterial regulatory proteins, luxR family//Sigma-70, region 4//DeoR-like helix-turn-helix domain//Transposase//Arginine repressor, DNA binding domain//Helix-turn-helix domain, rpiR family//Transposase//AsnC-type helix-turn-helix domain GO:0015074//GO:0006352//GO:0006355//GO:0006313//GO:0006525 DNA integration//DNA-templated transcription, initiation//regulation of transcription, DNA-templated//transposition, DNA-mediated//arginine metabolic process GO:0004803//GO:0003700//GO:0016987//GO:0043565//GO:0003677 transposase activity//transcription factor activity, sequence-specific DNA binding//sigma factor activity//sequence-specific DNA binding//DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex -- -- Cluster-8309.14077 BP_3 4.22 0.36 860 357610760 EHJ67138.1 386 9.7e-35 putative transposase-like protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- Q04202 193 9.6e-14 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14078 BP_3 7.00 0.37 1213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14079 BP_3 7.00 0.49 975 642914034 XP_008201516.1 150 2.6e-07 PREDICTED: syntaxin-binding protein 5 isoform X3 [Tribolium castaneum]>gi|642914036|ref|XP_008201517.1| PREDICTED: syntaxin-binding protein 5 isoform X3 [Tribolium castaneum] 642914037 XM_008203296.1 68 6.82253e-25 PREDICTED: Tribolium castaneum syntaxin-binding protein 5 (LOC657003), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14080 BP_3 15.00 0.82 1178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14081 BP_3 116.11 4.75 1471 270007349 EFA03797.1 818 1.3e-84 hypothetical protein TcasGA2_TC013909 [Tribolium castaneum] -- -- -- -- -- K19383 TGIF1 homeobox protein TGIF1 http://www.genome.jp/dbget-bin/www_bget?ko:K19383 Q15583 274 6.6e-23 Homeobox protein TGIF1 OS=Homo sapiens GN=TGIF1 PE=1 SV=3 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.14082 BP_3 89.76 2.65 1923 270007349 EFA03797.1 818 1.8e-84 hypothetical protein TcasGA2_TC013909 [Tribolium castaneum] -- -- -- -- -- K19383 TGIF1 homeobox protein TGIF1 http://www.genome.jp/dbget-bin/www_bget?ko:K19383 Q15583 274 8.7e-23 Homeobox protein TGIF1 OS=Homo sapiens GN=TGIF1 PE=1 SV=3 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.14083 BP_3 9.14 0.36 1512 270007349 EFA03797.1 818 1.4e-84 hypothetical protein TcasGA2_TC013909 [Tribolium castaneum] -- -- -- -- -- K19383 TGIF1 homeobox protein TGIF1 http://www.genome.jp/dbget-bin/www_bget?ko:K19383 Q15583 274 6.8e-23 Homeobox protein TGIF1 OS=Homo sapiens GN=TGIF1 PE=1 SV=3 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.14085 BP_3 21.27 0.38 2991 189236498 XP_975203.2 2117 6.4e-235 PREDICTED: protein lin-9 homolog isoform X1 [Tribolium castaneum] 817204910 XM_012422927.1 153 1.20061e-71 PREDICTED: Orussus abietinus protein lin-9 homolog (LOC105698571), transcript variant X4, mRNA -- -- -- -- Q8C735 1086 9.4e-117 Protein lin-9 homolog OS=Mus musculus GN=Lin9 PE=2 SV=2 PF05460//PF06584 Origin recognition complex subunit 6 (ORC6)//DIRP GO:0007049//GO:0006260//GO:0006351 cell cycle//DNA replication//transcription, DNA-templated GO:0003677 DNA binding GO:0005664//GO:0017053 nuclear origin of replication recognition complex//transcriptional repressor complex -- -- Cluster-8309.14086 BP_3 122.73 2.93 2311 189236498 XP_975203.2 2096 1.4e-232 PREDICTED: protein lin-9 homolog isoform X1 [Tribolium castaneum] 817204910 XM_012422927.1 153 9.25022e-72 PREDICTED: Orussus abietinus protein lin-9 homolog (LOC105698571), transcript variant X4, mRNA -- -- -- -- Q8C735 1086 7.3e-117 Protein lin-9 homolog OS=Mus musculus GN=Lin9 PE=2 SV=2 PF06584//PF05460 DIRP//Origin recognition complex subunit 6 (ORC6) GO:0007049//GO:0006351//GO:0006260 cell cycle//transcription, DNA-templated//DNA replication GO:0003677 DNA binding GO:0017053//GO:0005664 transcriptional repressor complex//nuclear origin of replication recognition complex -- -- Cluster-8309.14087 BP_3 27.82 0.56 2673 4559259 AAD22957.1 3576 0.0e+00 voltage-sensitive sodium channel [Leptinotarsa decemlineata] 4559258 AF114489.1 1154 0 AF114489 Leptinotarsa decemlineata voltage-sensitive sodium channel mRNA, partial cds K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 P35500 2602 1.4e-292 Sodium channel protein para OS=Drosophila melanogaster GN=para PE=2 SV=3 PF06512//PF06016//PF00520 Sodium ion transport-associated//Reovirus core-spike protein lambda-2 (L2)//Ion transport protein GO:0006811//GO:0009451//GO:0006370//GO:0006814//GO:0055085 ion transport//RNA modification//7-methylguanosine mRNA capping//sodium ion transport//transmembrane transport GO:0005216//GO:0004484//GO:0004482//GO:0005248//GO:0005524 ion channel activity//mRNA guanylyltransferase activity//mRNA (guanine-N7-)-methyltransferase activity//voltage-gated sodium channel activity//ATP binding GO:0016020//GO:0001518//GO:0019028 membrane//voltage-gated sodium channel complex//viral capsid -- -- Cluster-8309.1409 BP_3 2.00 1.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14092 BP_3 10.97 0.85 911 642915927 XP_008190814.1 470 1.9e-44 PREDICTED: centrosomal protein of 63 kDa-like [Tribolium castaneum]>gi|270003750|gb|EFA00198.1| hypothetical protein TcasGA2_TC003023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07716//PF02334//PF06005//PF04977//PF14304 Basic region leucine zipper//Replication terminator protein//Protein of unknown function (DUF904)//Septum formation initiator//Transcription termination and cleavage factor C-terminal GO:0006355//GO:0007049//GO:0043093//GO:0000917//GO:0006274//GO:0031124 regulation of transcription, DNA-templated//cell cycle//FtsZ-dependent cytokinesis//barrier septum assembly//DNA replication termination//mRNA 3'-end processing GO:0043565//GO:0003700//GO:0003677 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex -- -- Cluster-8309.14093 BP_3 197.00 6.85 1678 332374738 AEE62510.1 1044 9.5e-111 unknown [Dendroctonus ponderosae]>gi|478255086|gb|ENN75316.1| hypothetical protein YQE_08093, partial [Dendroctonus ponderosae]>gi|546678678|gb|ERL89246.1| hypothetical protein D910_06619 [Dendroctonus ponderosae] -- -- -- -- -- K14568 EMG1, NEP1 rRNA small subunit pseudouridine methyltransferase Nep1 http://www.genome.jp/dbget-bin/www_bget?ko:K14568 Q9W4J5 809 7.0e-85 Ribosomal RNA small subunit methyltransferase NEP1 OS=Drosophila melanogaster GN=CG3527 PE=3 SV=2 PF03587 EMG1/NEP1 methyltransferase -- -- GO:0008168 methyltransferase activity -- -- KOG3073 Protein required for 18S rRNA maturation and 40S ribosome biogenesis Cluster-8309.14097 BP_3 2.00 2.13 328 662212467 XP_008479970.1 181 2.2e-11 PREDICTED: zinc finger protein 425-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 143 2.3e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.1410 BP_3 7.00 0.55 905 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14100 BP_3 56.79 0.48 5975 270007354 EFA03802.1 2315 1.4e-257 hypothetical protein TcasGA2_TC013915 [Tribolium castaneum] 642917043 XM_008192874.1 244 6.2508e-122 PREDICTED: Tribolium castaneum diacylglycerol kinase eta-like (LOC103312380), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 B4I4Y1 1860 3.3e-206 Diacylglycerol kinase eta OS=Drosophila sechellia GN=GM10981 PE=3 SV=2 PF16866//PF02198//PF07649//PF00536//PF00130//PF00609//PF07647//PF02017//PF00781 PHD-finger//Sterile alpha motif (SAM)/Pointed domain//C1-like domain//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//SAM domain (Sterile alpha motif)//CIDE-N domain//Diacylglycerol kinase catalytic domain GO:0009395//GO:0007205//GO:0035556//GO:0055114//GO:0006915//GO:0046486 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//intracellular signal transduction//oxidation-reduction process//apoptotic process//glycerolipid metabolic process GO:0005515//GO:0004143//GO:0047134//GO:0043565//GO:0016301 protein binding//diacylglycerol kinase activity//protein-disulfide reductase activity//sequence-specific DNA binding//kinase activity GO:0005634//GO:0005622 nucleus//intracellular KOG1170 Diacylglycerol kinase Cluster-8309.14115 BP_3 29.12 0.88 1883 270015270 EFA11718.1 202 4.6e-13 hypothetical protein TcasGA2_TC001805 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF01637 THAP domain//Archaeal ATPase -- -- GO:0003676//GO:0005524 nucleic acid binding//ATP binding -- -- -- -- Cluster-8309.14121 BP_3 283.29 2.35 6095 642932366 XP_008197081.1 2298 1.3e-255 PREDICTED: protein jim lovell [Tribolium castaneum]>gi|642932368|ref|XP_008197082.1| PREDICTED: protein jim lovell [Tribolium castaneum]>gi|642932370|ref|XP_008197084.1| PREDICTED: protein jim lovell [Tribolium castaneum]>gi|642932372|ref|XP_008197085.1| PREDICTED: protein jim lovell [Tribolium castaneum]>gi|642932374|ref|XP_008197086.1| PREDICTED: protein jim lovell [Tribolium castaneum]>gi|270012342|gb|EFA08790.1| hypothetical protein TcasGA2_TC006481 [Tribolium castaneum] 462284309 APGK01056623.1 59 4.42136e-19 Dendroctonus ponderosae Seq01056633, whole genome shotgun sequence -- -- -- -- P14083 596 1.3e-59 Protein jim lovell OS=Drosophila melanogaster GN=lov PE=2 SV=2 PF05225//PF00651 helix-turn-helix, Psq domain//BTB/POZ domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.14127 BP_3 187.00 5.17 2034 91080603 XP_974067.1 757 2.2e-77 PREDICTED: RING finger protein 141 [Tribolium castaneum]>gi|270005817|gb|EFA02265.1| hypothetical protein TcasGA2_TC007929 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZM74 367 1.5e-33 RING finger protein 141 OS=Gallus gallus GN=RNF141 PE=2 SV=1 PF13639//PF00097//PF12678//PF17123//PF03854//PF12861//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//P-11 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0003723//GO:0004842//GO:0005515//GO:0008270//GO:0043169//GO:0046872 RNA binding//ubiquitin-protein transferase activity//protein binding//zinc ion binding//cation binding//metal ion binding GO:0005680 anaphase-promoting complex KOG1039 Predicted E3 ubiquitin ligase Cluster-8309.14128 BP_3 15.67 0.39 2214 751233081 XP_011170196.1 431 1.5e-39 PREDICTED: uncharacterized protein LOC105203130 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14129 BP_3 20.99 2.17 757 270016290 EFA12736.1 180 6.6e-11 hypothetical protein TcasGA2_TC002373 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14134 BP_3 30.21 1.02 1720 642921407 XP_973880.2 1031 3.1e-109 PREDICTED: glycerate kinase [Tribolium castaneum] -- -- -- -- -- K15788 GLYCTK glycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K15788 Q0VGK3 676 1.9e-69 Glycerate kinase OS=Rattus norvegicus GN=Glyctk PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3935 Predicted glycerate kinase Cluster-8309.14141 BP_3 67.20 2.65 1516 546673103 ERL84772.1 991 1.2e-104 hypothetical protein D910_02197 [Dendroctonus ponderosae] -- -- -- -- -- K02328 POLD2 DNA polymerase delta subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02328 P49005 606 2.2e-61 DNA polymerase delta subunit 2 OS=Homo sapiens GN=POLD2 PE=1 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG2732 DNA polymerase delta, regulatory subunit 55 Cluster-8309.14146 BP_3 89.42 0.60 7440 823393575 XP_012411540.1 740 7.5e-75 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like [Trichechus manatus latirostris] -- -- -- -- -- K15338 GEN1, GEN flap endonuclease GEN http://www.genome.jp/dbget-bin/www_bget?ko:K15338 P51523 714 3.2e-73 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF01040//PF00096//PF00867//PF06814//PF06467//PF07776//PF00752//PF13465//PF02892//PF13912 UbiA prenyltransferase family//Zinc finger, C2H2 type//XPG I-region//Lung seven transmembrane receptor//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//XPG N-terminal domain//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger GO:0006281 DNA repair GO:0008270//GO:0004518//GO:0046872//GO:0003677//GO:0004659 zinc ion binding//nuclease activity//metal ion binding//DNA binding//prenyltransferase activity GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.14148 BP_3 45.14 0.32 7146 617653008 XP_007534608.1 684 2.3e-68 PREDICTED: zinc finger protein 420-like [Erinaceus europaeus] -- -- -- -- -- K15338 GEN1, GEN flap endonuclease GEN http://www.genome.jp/dbget-bin/www_bget?ko:K15338 Q9P2J8 632 9.9e-64 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF06689//PF13465//PF00752//PF13912//PF01363//PF02892//PF00130//PF01155//PF00096//PF16588//PF07776//PF00867//PF06814 ClpX C4-type zinc finger//Zinc-finger double domain//XPG N-terminal domain//C2H2-type zinc finger//FYVE zinc finger//BED zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//C2H2 zinc-finger//Zinc-finger associated domain (zf-AD)//XPG I-region//Lung seven transmembrane receptor GO:0035556//GO:0006281//GO:0006464 intracellular signal transduction//DNA repair//cellular protein modification process GO:0046872//GO:0004518//GO:0003676//GO:0008270//GO:0016151//GO:0046983//GO:0003677 metal ion binding//nuclease activity//nucleic acid binding//zinc ion binding//nickel cation binding//protein dimerization activity//DNA binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.14150 BP_3 106.03 3.41 1791 91082813 XP_968677.1 1347 7.4e-146 PREDICTED: transmembrane protein 43 homolog [Tribolium castaneum]>gi|270007099|gb|EFA03547.1| hypothetical protein TcasGA2_TC013551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSB9 736 2.2e-76 Transmembrane protein 43 homolog OS=Drosophila melanogaster GN=CG8111 PE=2 SV=1 PF15184 Mitochondrial import receptor subunit TOM6 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.14155 BP_3 34.60 1.26 1620 332374692 AEE62487.1 742 9.6e-76 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8QZW3 348 1.9e-31 Protein FAM151A OS=Mus musculus GN=Fam151a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14158 BP_3 471.20 36.15 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14160 BP_3 209.57 4.89 2359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14161 BP_3 4.00 0.95 494 795017073 XP_011858722.1 139 2.4e-06 PREDICTED: uncharacterized protein LOC105556247 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14164 BP_3 38.15 0.51 3905 607359137 EZA53515.1 1371 2.7e-148 hypothetical protein X777_07025 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07731//PF00105//PF03175 Multicopper oxidase//Zinc finger, C4 type (two domains)//DNA polymerase type B, organellar and viral GO:0055114//GO:0006260//GO:0006355 oxidation-reduction process//DNA replication//regulation of transcription, DNA-templated GO:0016491//GO:0003887//GO:0005507//GO:0003677//GO:0003700//GO:0008408//GO:0008270//GO:0000166//GO:0043565 oxidoreductase activity//DNA-directed DNA polymerase activity//copper ion binding//DNA binding//transcription factor activity, sequence-specific DNA binding//3'-5' exonuclease activity//zinc ion binding//nucleotide binding//sequence-specific DNA binding GO:0042575//GO:0005667//GO:0005634 DNA polymerase complex//transcription factor complex//nucleus -- -- Cluster-8309.14165 BP_3 2.08 0.72 430 642937838 XP_008200322.1 372 2.0e-33 PREDICTED: tyrosine-protein kinase Fps85D isoform X1 [Tribolium castaneum]>gi|270000733|gb|EEZ97180.1| hypothetical protein TcasGA2_TC004367 [Tribolium castaneum] -- -- -- -- -- K07527 FES, FPS tyrosine-protein kinase Fes/Fps http://www.genome.jp/dbget-bin/www_bget?ko:K07527 P18106 309 1.7e-27 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF13631//PF00069//PF07714 Cytochrome b(N-terminal)/b6/petB//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0006118 protein phosphorylation//obsolete electron transport GO:0016491//GO:0004713//GO:0005524//GO:0004672//GO:0009055 oxidoreductase activity//protein tyrosine kinase activity//ATP binding//protein kinase activity//electron carrier activity GO:0016020 membrane KOG0194 Protein tyrosine kinase Cluster-8309.14169 BP_3 23.00 3.63 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14170 BP_3 21.48 0.41 2805 766938860 XP_011501956.1 794 1.6e-81 PREDICTED: uncharacterized protein LOC105365477 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03505//PF00884 Clostridium enterotoxin//Sulfatase GO:0009405//GO:0008152 pathogenesis//metabolic process GO:0008484 sulfuric ester hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.14171 BP_3 1.00 0.64 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14172 BP_3 25.07 0.56 2444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14173 BP_3 212.00 2.84 3888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01654 Cytochrome bd terminal oxidase subunit I -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.14176 BP_3 241.00 10.86 1361 270004308 EFA00756.1 716 8.3e-73 hypothetical protein TcasGA2_TC003641 [Tribolium castaneum] -- -- -- -- -- K15280 SLC35C2 solute carrier family 35, member C2 http://www.genome.jp/dbget-bin/www_bget?ko:K15280 Q9VM17 431 3.8e-41 SOSS complex subunit B homolog OS=Drosophila melanogaster GN=CG5181 PE=2 SV=1 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG3416 Predicted nucleic acid binding protein Cluster-8309.14183 BP_3 41.00 1.34 1763 157954027 NP_001103243.1 1445 3.2e-157 ligand-gated ion channel subunit precursor [Tribolium castaneum]>gi|156447627|gb|ABU63606.1| ligand-gated ion channel subunit [Tribolium castaneum]>gi|270002893|gb|EEZ99340.1| ligand-gated ion channel subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61603 505 1.3e-49 Glycine receptor subunit alpha-4 OS=Mus musculus GN=Glra4 PE=2 SV=3 PF02931//PF02932//PF02212//PF08121 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region//Dynamin GTPase effector domain//Waglerin family GO:0006811//GO:0007165//GO:0006810//GO:0007268 ion transport//signal transduction//transport//synaptic transmission GO:0005230//GO:0005525//GO:0030550//GO:0003924 extracellular ligand-gated ion channel activity//GTP binding//acetylcholine receptor inhibitor activity//GTPase activity GO:0016020//GO:0005576//GO:0030054//GO:0045211//GO:0005886//GO:0016021 membrane//extracellular region//cell junction//postsynaptic membrane//plasma membrane//integral component of membrane -- -- Cluster-8309.14184 BP_3 1.00 0.34 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14186 BP_3 39.00 3.03 912 -- -- -- -- -- 697072984 XM_009652948.1 900 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14188 BP_3 32.88 0.84 2174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14190 BP_3 779.56 8.14 4905 642918266 XP_008191438.1 6923 0.0e+00 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] 755988817 XM_011313677.1 459 0 PREDICTED: Fopius arisanus dual oxidase (LOC105271872), mRNA K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 6223 0.0e+00 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 PF13499//PF13833//PF13405//PF12763//PF08030//PF08022//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand//Ferric reductase NAD binding domain//FAD-binding domain//EF hand//EF hand GO:0055114 oxidation-reduction process GO:0005509//GO:0005515//GO:0016491 calcium ion binding//protein binding//oxidoreductase activity -- -- KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.14192 BP_3 7.09 0.55 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14194 BP_3 2.00 0.40 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14196 BP_3 62.62 0.68 4702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02505//PF00424//PF05699//PF11837 Methyl-coenzyme M reductase operon protein D//REV protein (anti-repression trans-activator protein)//hAT family C-terminal dimerisation region//Domain of unknown function (DUF3357) GO:0006355//GO:0015948//GO:0005982//GO:0005985//GO:0006012 regulation of transcription, DNA-templated//methanogenesis//starch metabolic process//sucrose metabolic process//galactose metabolic process GO:0003700//GO:0004564//GO:0046983//GO:0004575 transcription factor activity, sequence-specific DNA binding//beta-fructofuranosidase activity//protein dimerization activity//sucrose alpha-glucosidase activity GO:0017177//GO:0005667//GO:0042025 glucosidase II complex//transcription factor complex//host cell nucleus -- -- Cluster-8309.14197 BP_3 47.52 0.44 5465 270007033 EFA03481.1 420 7.1e-38 hypothetical protein TcasGA2_TC013480 [Tribolium castaneum] 332373577 BT126968.1 83 1.80447e-32 Dendroctonus ponderosae clone DPO1325_L24 unknown mRNA K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P05031 391 6.7e-36 Aromatic-L-amino-acid decarboxylase OS=Drosophila melanogaster GN=Ddc PE=1 SV=4 PF00282 Pyridoxal-dependent decarboxylase conserved domain GO:0019752 carboxylic acid metabolic process GO:0016831//GO:0030170 carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.14198 BP_3 13.40 1.31 785 642933067 XP_971928.3 718 2.8e-73 PREDICTED: uncharacterized serine/threonine-protein kinase SgK494 [Tribolium castaneum] -- -- -- -- -- K17529 SGK494 uncharacterized serine/threonine-protein kinase SgK494 http://www.genome.jp/dbget-bin/www_bget?ko:K17529 Q8MYQ1 370 2.6e-34 Putative serine/threonine-protein kinase F31E3.2 OS=Caenorhabditis elegans GN=F31E3.2 PE=3 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.14199 BP_3 56.41 1.48 2126 91082233 XP_972708.1 1193 6.4e-128 PREDICTED: 2',5'-phosphodiesterase 12 [Tribolium castaneum]>gi|270007451|gb|EFA03899.1| hypothetical protein TcasGA2_TC014029 [Tribolium castaneum] 752886955 XM_011263028.1 45 9.2513e-12 PREDICTED: Camponotus floridanus 2',5'-phosphodiesterase 12-like (LOC105254385), partial mRNA K19612 PDE12 2',5'-phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19612 Q6AXQ5 772 1.7e-80 2',5'-phosphodiesterase 12 OS=Rattus norvegicus GN=Pde12 PE=2 SV=1 PF01304 Gas vesicles protein GVPc repeated domain GO:0031412 gas vesicle organization -- -- GO:0031411 gas vesicle KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.14201 BP_3 32.00 2.11 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14203 BP_3 38.23 1.22 1799 642916330 XP_008190976.1 693 5.1e-70 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|270004190|gb|EFA00638.1| hypothetical protein TcasGA2_TC003514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25386 149 2.5e-08 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF02183//PF10473 Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006355 regulation of transcription, DNA-templated GO:0008134//GO:0045502//GO:0003700//GO:0042803//GO:0043565 transcription factor binding//dynein binding//transcription factor activity, sequence-specific DNA binding//protein homodimerization activity//sequence-specific DNA binding GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.14205 BP_3 5.00 0.38 922 642923176 XP_008193641.1 225 4.9e-16 PREDICTED: kinesin-like protein subito isoform X2 [Tribolium castaneum] -- -- -- -- -- K10402 KIF20 kinesin family member 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10402 Q9V877 144 4.9e-08 Kinesin-like protein subito OS=Drosophila melanogaster GN=sub PE=1 SV=1 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.14208 BP_3 10.86 0.47 1417 646700417 KDR10578.1 176 3.6e-10 3'(2'),5'-bisphosphate nucleotidase 1 [Zootermopsis nevadensis] -- -- -- -- -- K01082 cysQ, MET22, BPNT1 3'(2'), 5'-bisphosphate nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14213 BP_3 5.00 0.59 703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14214 BP_3 1.00 0.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14217 BP_3 25.78 0.40 3435 642925170 XP_008194455.1 1287 1.3e-138 PREDICTED: endoglucanase 5-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26224 615 4.5e-62 Endoglucanase F OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) GN=celF PE=3 SV=1 PF09204//PF00759 Bacterial self-protective colicin-like immunity//Glycosyl hydrolase family 9 GO:0006955//GO:0030153//GO:0005975 immune response//bacteriocin immunity//carbohydrate metabolic process GO:0004553//GO:0015643 hydrolase activity, hydrolyzing O-glycosyl compounds//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.14218 BP_3 29.79 0.47 3354 642925172 XP_001810693.2 1298 6.7e-140 PREDICTED: endoglucanase 5-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26224 620 1.1e-62 Endoglucanase F OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) GN=celF PE=3 SV=1 PF00759//PF09204 Glycosyl hydrolase family 9//Bacterial self-protective colicin-like immunity GO:0005975//GO:0006955//GO:0030153 carbohydrate metabolic process//immune response//bacteriocin immunity GO:0015643//GO:0004553 toxic substance binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0019814 immunoglobulin complex -- -- Cluster-8309.14221 BP_3 24.00 0.84 1665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14223 BP_3 98.90 6.15 1067 642931641 XP_008196668.1 727 3.5e-74 PREDICTED: tetratricopeptide repeat protein 26 [Tribolium castaneum]>gi|270012187|gb|EFA08635.1| hypothetical protein TcasGA2_TC006298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4III8 566 6.7e-57 Intraflagellar transport protein 56 OS=Xenopus tropicalis GN=ttc26 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3785 Uncharacterized conserved protein Cluster-8309.14224 BP_3 134.15 5.04 1574 642931641 XP_008196668.1 2169 3.2e-241 PREDICTED: tetratricopeptide repeat protein 26 [Tribolium castaneum]>gi|270012187|gb|EFA08635.1| hypothetical protein TcasGA2_TC006298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U2N8 1719 2.0e-190 Intraflagellar transport protein 56 OS=Rattus norvegicus GN=Ttc26 PE=2 SV=1 PF13176//PF13414//PF13174//PF13371//PF13181//PF00515 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG3785 Uncharacterized conserved protein Cluster-8309.14226 BP_3 278.45 18.28 1026 478263683 ENN81989.1 580 3.7e-57 hypothetical protein YQE_01700, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5E9E8 222 5.0e-17 Protein YIPF5 OS=Bos taurus GN=YIPF5 PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG3103 Rab GTPase interacting factor, Golgi membrane protein Cluster-8309.14232 BP_3 20.41 1.33 1031 642933131 XP_008197270.1 796 3.3e-82 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] 462326012 APGK01041603.1 84 9.21934e-34 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- Q8N4B1 379 3.1e-35 Sesquipedalian-1 OS=Homo sapiens GN=FAM109A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14237 BP_3 6.79 0.88 665 642937652 XP_966876.3 254 1.5e-19 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54963 218 9.3e-17 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.14238 BP_3 180.00 18.61 758 478258213 ENN78342.1 476 3.1e-45 hypothetical protein YQE_05144, partial [Dendroctonus ponderosae]>gi|546677009|gb|ERL87925.1| hypothetical protein D910_05313, partial [Dendroctonus ponderosae] -- -- -- -- -- K10745 RNASEH2C ribonuclease H2 subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K10745 Q8TDP1 128 2.9e-06 Ribonuclease H2 subunit C OS=Homo sapiens GN=RNASEH2C PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14239 BP_3 63.00 3.73 1105 820805530 AKG92756.1 750 7.7e-77 enhancer of split mgamma protein 1 [Leptinotarsa decemlineata] 759049712 XM_011335617.1 41 7.93163e-10 PREDICTED: Cerapachys biroi enhancer of split mbeta protein-like (LOC105277336), mRNA K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 Q01070 422 3.4e-40 Enhancer of split mgamma protein OS=Drosophila melanogaster GN=HLHmgamma PE=2 SV=1 PF07527//PF00010 Hairy Orange//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.14241 BP_3 164.00 3.89 2325 642926758 XP_008195001.1 938 2.6e-98 PREDICTED: gastrula zinc finger protein XlCGF52.1-like [Tribolium castaneum]>gi|270008400|gb|EFA04848.1| hypothetical protein TcasGA2_TC014900 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RB30 549 1.4e-54 Zinc finger protein 585B OS=Pongo abelii GN=ZNF585B PE=2 SV=1 PF00096//PF13465//PF07776//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.14247 BP_3 61.48 1.29 2584 748995278 AJE75661.1 1243 1.2e-133 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09848 923 6.5e-98 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.14253 BP_3 223.95 5.22 2360 642928954 XP_008195631.1 1105 1.1e-117 PREDICTED: checkpoint protein HUS1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H0R3 570 5.1e-57 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 PF04005//PF02747 Hus1-like protein//Proliferating cell nuclear antigen, C-terminal domain GO:0006281//GO:0006275//GO:0000077 DNA repair//regulation of DNA replication//DNA damage checkpoint GO:0003677 DNA binding GO:0030896 checkpoint clamp complex KOG3999 Checkpoint 9-1-1 complex, HUS1 component Cluster-8309.14255 BP_3 33.83 0.77 2409 642928954 XP_008195631.1 866 6.0e-90 PREDICTED: checkpoint protein HUS1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H0R3 570 5.2e-57 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 PF02747//PF04005 Proliferating cell nuclear antigen, C-terminal domain//Hus1-like protein GO:0006281//GO:0006275//GO:0000077 DNA repair//regulation of DNA replication//DNA damage checkpoint GO:0003677 DNA binding GO:0030896 checkpoint clamp complex KOG3999 Checkpoint 9-1-1 complex, HUS1 component Cluster-8309.14256 BP_3 26.05 0.41 3389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14257 BP_3 2.00 2.75 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14261 BP_3 30.31 0.44 3590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529//PF05188 DHHC palmitoyltransferase//MutS domain II GO:0006298 mismatch repair GO:0008270//GO:0005524//GO:0030983 zinc ion binding//ATP binding//mismatched DNA binding -- -- -- -- Cluster-8309.14263 BP_3 51.61 1.71 1748 546675135 ERL86379.1 691 8.5e-70 hypothetical protein D910_03787, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N2G6 463 9.6e-45 Zinc finger CCHC domain-containing protein 24 OS=Homo sapiens GN=ZCCHC24 PE=1 SV=1 PF07562 Nine Cysteines Domain of family 3 GPCR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.14264 BP_3 124.25 0.38 15862 478253883 ENN74175.1 2317 2.2e-257 hypothetical protein YQE_09148, partial [Dendroctonus ponderosae] 887513412 KP641329.1 728 0 Leptinotarsa decemlineata putative aryl hydrocarbon receptor Dys mRNA, complete cds -- -- -- -- Q8IUM7 514 1.1e-49 Neuronal PAS domain-containing protein 4 OS=Homo sapiens GN=NPAS4 PE=1 SV=1 PF08447//PF00041//PF00320//PF05060//PF00989 PAS fold//Fibronectin type III domain//GATA zinc finger//N-acetylglucosaminyltransferase II (MGAT2)//PAS fold GO:0006355//GO:0009312 regulation of transcription, DNA-templated//oligosaccharide biosynthetic process GO:0008270//GO:0043565//GO:0003700//GO:0005515//GO:0008455 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GO:0005795//GO:0016021//GO:0005667 Golgi stack//integral component of membrane//transcription factor complex -- -- Cluster-8309.14265 BP_3 64.00 1.93 1891 478250264 ENN70764.1 921 2.0e-96 hypothetical protein YQE_12552, partial [Dendroctonus ponderosae]>gi|546685959|gb|ERL95373.1| hypothetical protein D910_12637 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SYC1 244 2.6e-19 Clavesin-2 OS=Homo sapiens GN=CLVS2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14266 BP_3 41.49 1.58 1555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14268 BP_3 2.00 0.31 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14269 BP_3 12.36 0.39 1811 642937652 XP_966876.3 580 6.5e-57 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17010 364 3.0e-33 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF02751//PF00096//PF13465//PF05401 Transcription initiation factor IIA, gamma subunit//Zinc finger, C2H2 type//Zinc-finger double domain//Nodulation protein S (NodS) GO:0009877//GO:0009312//GO:0006367 nodulation//oligosaccharide biosynthetic process//transcription initiation from RNA polymerase II promoter GO:0008757//GO:0046872 S-adenosylmethionine-dependent methyltransferase activity//metal ion binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.1427 BP_3 5.29 0.37 987 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15836 SSTK-interacting protein, TSSK6-activating co-chaperone protein -- -- GO:0051087 chaperone binding -- -- -- -- Cluster-8309.14271 BP_3 2.00 0.99 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14274 BP_3 29.99 0.46 3464 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.6e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14276 BP_3 120.00 2.15 2986 642929093 XP_008195688.1 588 1.3e-57 PREDICTED: uncharacterized protein LOC103313644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05372//PF00598 Delta lysin family//Influenza Matrix protein (M1) GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005198//GO:0003723 structural molecule activity//RNA binding GO:0005576 extracellular region -- -- Cluster-8309.14278 BP_3 230.57 3.02 3973 871211803 XP_012946119.1 440 2.5e-40 PREDICTED: collagen alpha-1(I) chain-like [Aplysia californica] 170039347 XM_001847447.1 45 1.74132e-11 Culex quinquefasciatus collagen alpha 1(XVIII) chain, mRNA K08135 COL15A collagen, type XV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08135 P02453 359 2.5e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF10660//PF06482 Iron-containing outer mitochondrial membrane protein N-terminus//Collagenase NC10 and Endostatin GO:0007155 cell adhesion GO:0005198//GO:0051537 structural molecule activity//2 iron, 2 sulfur cluster binding GO:0031012//GO:0043231 extracellular matrix//intracellular membrane-bounded organelle -- -- Cluster-8309.14279 BP_3 1.00 0.67 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14281 BP_3 7.70 0.40 1230 270006485 EFA02933.1 179 1.4e-10 gustatory receptor 99 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.143 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14303 BP_3 8.01 0.42 1203 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14304 BP_3 27.91 0.50 2963 642913543 XP_971895.2 587 1.7e-57 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 4.5e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF06003 Survival motor neuron protein (SMN) GO:0006397 mRNA processing GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.14307 BP_3 54.78 1.00 2938 332376993 AEE63636.1 2012 9.5e-223 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14304 NUP85 nuclear pore complex protein Nup85 http://www.genome.jp/dbget-bin/www_bget?ko:K14304 Q8R480 847 4.8e-89 Nuclear pore complex protein Nup85 OS=Mus musculus GN=Nup85 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14308 BP_3 3.00 0.95 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14309 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1431 BP_3 5.00 0.33 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14311 BP_3 6.00 0.48 896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14314 BP_3 48.05 0.34 7040 642936341 XP_008198402.1 1821 3.2e-200 PREDICTED: adenylate kinase 9-like [Tribolium castaneum]>gi|270013134|gb|EFA09582.1| hypothetical protein TcasGA2_TC011699 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TCS8 405 2.1e-37 Adenylate kinase 9 OS=Homo sapiens GN=AK9 PE=1 SV=2 PF00004//PF02224//PF00910 ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//RNA helicase GO:0006206//GO:0006139 pyrimidine nucleobase metabolic process//nucleobase-containing compound metabolic process GO:0004127//GO:0005524//GO:0003723//GO:0003724 cytidylate kinase activity//ATP binding//RNA binding//RNA helicase activity -- -- -- -- Cluster-8309.14321 BP_3 126.01 4.67 1593 642930251 XP_971223.2 984 8.2e-104 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 132 2.1e-06 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14322 BP_3 72.94 1.44 2735 576249490 AHH29251.1 2457 2.2e-274 Inebriated-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 1932 6.8e-215 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF00209//PF01384 Sodium:neurotransmitter symporter family//Phosphate transporter family GO:0006817//GO:0006812//GO:0006836 phosphate ion transport//cation transport//neurotransmitter transport GO:0005328//GO:0005315 neurotransmitter:sodium symporter activity//inorganic phosphate transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.14323 BP_3 10.00 1.15 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11857 Domain of unknown function (DUF3377) -- -- GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.14325 BP_3 510.00 14.35 2005 768441096 XP_011562253.1 2001 1.2e-221 PREDICTED: AP-1 complex subunit mu-1 [Plutella xylostella] 807016054 XM_004518056.2 330 3.23361e-170 PREDICTED: Ceratitis capitata AP-1 complex subunit mu-1 (LOC101462016), mRNA K12393 AP1M AP-1 complex subunit mu http://www.genome.jp/dbget-bin/www_bget?ko:K12393 Q2KJ81 1811 5.4e-201 AP-1 complex subunit mu-1 OS=Bos taurus GN=AP1M1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0937 Adaptor complexes medium subunit family Cluster-8309.14328 BP_3 12.13 0.54 1380 270007599 EFA04047.1 786 6.5e-81 hypothetical protein TcasGA2_TC014279 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 381 2.4e-35 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.14331 BP_3 826.00 24.45 1920 478252326 ENN72752.1 1159 5.0e-124 hypothetical protein YQE_10557, partial [Dendroctonus ponderosae] -- -- -- -- -- K13165 SFRS12 splicing factor, arginine/serine-rich 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13165 O01159 466 4.7e-45 Probable splicing factor, arginine/serine-rich 7 OS=Caenorhabditis elegans GN=rsp-7 PE=3 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4676 Splicing factor, arginine/serine-rich Cluster-8309.14332 BP_3 1.00 2.02 296 321479268 EFX90224.1 226 1.2e-16 hypothetical protein DAPPUDRAFT_299950 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13903//PF00822 PMP-22/EMP/MP20/Claudin tight junction//PMP-22/EMP/MP20/Claudin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.14333 BP_3 32.00 6.97 513 328899579 AEB54641.1 570 2.7e-56 ribosomal protein L32 [Procambarus clarkii] -- -- -- -- -- K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q962T1 490 2.1e-48 60S ribosomal protein L32 OS=Spodoptera frugiperda GN=RpL32 PE=2 SV=1 PF01655 Ribosomal protein L32 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0878 60S ribosomal protein L32 Cluster-8309.14335 BP_3 536.00 11.99 2446 642918152 XP_008191389.1 1039 5.3e-110 PREDICTED: uncharacterized protein LOC103312472 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13851 Growth-arrest specific micro-tubule binding GO:0048870 cell motility -- -- GO:0031514 motile cilium -- -- Cluster-8309.14341 BP_3 71.91 0.98 3839 478263448 ENN81809.1 1913 3.7e-211 hypothetical protein YQE_01814, partial [Dendroctonus ponderosae]>gi|478263929|gb|ENN82095.1| hypothetical protein YQE_01527, partial [Dendroctonus ponderosae] 817188109 XM_012433187.1 139 9.36541e-64 PREDICTED: Orussus abietinus tubulin alpha chain-like (LOC105704177), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q7Z3E2 921 1.6e-97 Coiled-coil domain-containing protein 186 OS=Homo sapiens GN=CCDC186 PE=1 SV=2 PF13014 KH domain -- -- GO:0003723 RNA binding -- -- KOG1376 Alpha tubulin Cluster-8309.14343 BP_3 8.66 0.47 1187 642930369 XP_008196368.1 820 6.3e-85 PREDICTED: dymeclin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q293C2 400 1.3e-37 Dymeclin OS=Drosophila pseudoobscura pseudoobscura GN=GA20914 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14345 BP_3 30.22 1.05 1685 270015237 EFA11685.1 969 4.8e-102 hypothetical protein TcasGA2_TC008549 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS86 569 4.7e-57 LanC-like protein 2 OS=Homo sapiens GN=LANCL2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2787 Lanthionine synthetase C-like protein 1 Cluster-8309.14347 BP_3 5.00 1.71 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14349 BP_3 148.39 8.38 1145 91087377 XP_975644.1 366 2.7e-32 PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum]>gi|642929867|ref|XP_008196006.1| PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum] -- -- -- -- -- K02219 CKS1 cyclin-dependent kinase regulatory subunit CKS1 http://www.genome.jp/dbget-bin/www_bget?ko:K02219 Q24152 323 1.1e-28 Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster GN=Cks30A PE=3 SV=1 PF01111 Cyclin-dependent kinase regulatory subunit GO:0045859//GO:0007049 regulation of protein kinase activity//cell cycle GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG3484 Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins Cluster-8309.14350 BP_3 15.00 1.55 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14351 BP_3 10.00 0.80 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14352 BP_3 27.00 0.78 1951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14356 BP_3 416.09 3.63 5815 642915956 XP_008190826.1 3245 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein kinase C, brain isozyme-like [Tribolium castaneum] 642915955 XM_008192604.1 625 0 PREDICTED: Tribolium castaneum protein kinase C, brain isozyme-like (LOC656250), mRNA K02677 CPKC classical protein kinase C http://www.genome.jp/dbget-bin/www_bget?ko:K02677 P05130 2723 2.8e-306 Protein kinase C, brain isozyme OS=Drosophila melanogaster GN=Pkc53E PE=2 SV=2 PF00168//PF00433//PF07714//PF07649//PF00628//PF00069//PF09472//PF00130 C2 domain//Protein kinase C terminal domain//Protein tyrosine kinase//C1-like domain//PHD-finger//Protein kinase domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556//GO:0015948//GO:0009069//GO:0006468//GO:0046656//GO:0016310 oxidation-reduction process//intracellular signal transduction//methanogenesis//serine family amino acid metabolic process//protein phosphorylation//folic acid biosynthetic process//phosphorylation GO:0047134//GO:0004672//GO:0004674//GO:0005524//GO:0030269//GO:0005515 protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity//ATP binding//tetrahydromethanopterin S-methyltransferase activity//protein binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.14357 BP_3 41.12 1.20 1943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14358 BP_3 12.39 0.48 1544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14361 BP_3 181.00 14.07 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14362 BP_3 7.28 0.49 1009 189237166 XP_974303.2 484 4.9e-46 PREDICTED: transmembrane protein 198 isoform X1 [Tribolium castaneum]>gi|270007195|gb|EFA03643.1| hypothetical protein TcasGA2_TC013737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q498W5 222 4.9e-17 Transmembrane protein 198-B OS=Danio rerio GN=tmem198b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14363 BP_3 6.00 0.36 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14366 BP_3 3.00 0.57 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14367 BP_3 10.00 1.35 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14368 BP_3 45.00 3.96 840 83939666 ABC48600.1 1268 5.1e-137 ribosomal protein L8 [Litopenaeus vannamei] 83939665 DQ316258.1 348 1.30481e-180 Litopenaeus vannamei ribosomal protein L8 mRNA, complete cds K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q95V39 1130 2.1e-122 60S ribosomal protein L8 OS=Spodoptera frugiperda GN=RpL8 PE=2 SV=1 PF03947//PF00181 Ribosomal Proteins L2, C-terminal domain//Ribosomal Proteins L2, RNA binding domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2309 60s ribosomal protein L2/L8 Cluster-8309.1437 BP_3 33.00 0.31 5504 642929706 XP_008195943.1 2881 0.0e+00 PREDICTED: hemicentin-2 [Tribolium castaneum] 642929705 XM_008197721.1 530 0 PREDICTED: Tribolium castaneum hemicentin-2 (LOC664460), mRNA -- -- -- -- Q9P2J2 263 4.7e-21 Protein turtle homolog A OS=Homo sapiens GN=IGSF9 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14371 BP_3 264.00 16.43 1066 91094099 XP_967118.1 890 4.4e-93 PREDICTED: N-alpha-acetyltransferase 40 [Tribolium castaneum]>gi|270010877|gb|EFA07325.1| hypothetical protein TcasGA2_TC015921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q568K5 523 6.4e-52 N-alpha-acetyltransferase 40 OS=Danio rerio GN=naa40 PE=2 SV=1 PF00583//PF13508//PF08445 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG2488 Acetyltransferase (GNAT) domain-containing protein Cluster-8309.14372 BP_3 33.96 1.62 1301 321476603 EFX87563.1 259 7.8e-20 hypothetical protein DAPPUDRAFT_42775, partial [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q9VBW3 202 1.3e-14 Tyrosine kinase receptor Cad96Ca OS=Drosophila melanogaster GN=Cad96Ca PE=2 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.14375 BP_3 1067.00 16.30 3446 642939976 XP_968254.2 241 2.5e-17 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270015788|gb|EFA12236.1| hypothetical protein TcasGA2_TC006924 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14377 BP_3 185.75 4.53 2270 642919931 XP_974732.3 1610 3.0e-176 PREDICTED: tetratricopeptide repeat protein 5-like [Tribolium castaneum]>gi|270005358|gb|EFA01806.1| hypothetical protein TcasGA2_TC007407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BK48 883 2.5e-93 Tetratricopeptide repeat protein 5 OS=Rattus norvegicus GN=Ttc5 PE=2 SV=1 PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14379 BP_3 1.00 13.22 236 2098753 AAC47523.1 294 1.2e-24 alpha-2-tubulin [Gecarcinus lateralis] 2098752 U92646.1 148 4.99463e-70 GLU92646 Gecarcinus lateralis alpha-2-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q94572 265 1.2e-22 Tubulin alpha-3 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.14381 BP_3 136.00 3.72 2053 735997411 NP_001290187.1 1240 2.2e-133 neuromedin-U receptor 2-like [Tribolium castaneum]>gi|189241567|ref|XP_968501.2| PREDICTED: neuromedin-U receptor 2-like [Tribolium castaneum]>gi|728893173|gb|AIZ00520.1| pyrokinin 1 receptor C [Tribolium castaneum] 749791816 XM_011150823.1 125 3.01311e-56 PREDICTED: Harpegnathos saltator neuromedin-U receptor 2-like (LOC105189016), transcript variant X3, mRNA K05052 NMUR1 neuromedin U receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05052 Q9GZQ4 528 3.3e-52 Neuromedin-U receptor 2 OS=Homo sapiens GN=NMUR2 PE=1 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.14383 BP_3 77.36 2.08 2082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03600 Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.14384 BP_3 9.00 0.78 846 642937921 XP_008199131.1 851 1.1e-88 PREDICTED: synapsin, partial [Tribolium castaneum] 642937920 XM_008200909.1 235 8.61238e-118 PREDICTED: Tribolium castaneum synapsin (LOC659883), partial mRNA -- -- -- -- Q24546 409 8.4e-39 Synapsin OS=Drosophila melanogaster GN=Syn PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14386 BP_3 343.00 35.01 764 642920339 XP_008192304.1 529 2.3e-51 PREDICTED: dnaJ-like protein 60 [Tribolium castaneum] -- -- -- -- -- K09536 DNAJC16 DnaJ homolog subfamily C member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K09536 P92029 222 3.7e-17 DnaJ-like protein 60 OS=Drosophila melanogaster GN=DnaJ-60 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.14389 BP_3 536.63 13.21 2250 478252437 ENN72860.1 1477 7.9e-161 hypothetical protein YQE_10509, partial [Dendroctonus ponderosae]>gi|546673468|gb|ERL85066.1| hypothetical protein D910_02489 [Dendroctonus ponderosae] -- -- -- -- -- K01639 E4.1.3.3, nanA, NPL N-acetylneuraminate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01639 Q66H59 334 1.1e-29 N-acetylneuraminate lyase OS=Rattus norvegicus GN=Npl PE=2 SV=1 PF00701 Dihydrodipicolinate synthetase family GO:0008152 metabolic process GO:0016829 lyase activity -- -- -- -- Cluster-8309.1439 BP_3 15.00 0.63 1442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14390 BP_3 28.48 0.86 1897 478252437 ENN72860.1 517 1.4e-49 hypothetical protein YQE_10509, partial [Dendroctonus ponderosae]>gi|546673468|gb|ERL85066.1| hypothetical protein D910_02489 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14394 BP_3 23.45 1.27 1185 642934528 XP_008197700.1 858 2.5e-89 PREDICTED: platelet-derived growth factor receptor alpha isoform X3 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 427 9.7e-41 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.14395 BP_3 36.04 1.17 1776 642934524 XP_008197698.1 361 1.6e-31 PREDICTED: uncharacterized protein LOC100141936 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 212 1.2e-15 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.14396 BP_3 14.91 0.50 1719 642934530 XP_008197701.1 366 4.0e-32 PREDICTED: fibroblast growth factor receptor 4 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 212 1.2e-15 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.14398 BP_3 2.91 0.48 586 546674960 ERL86230.1 305 1.6e-25 hypothetical protein D910_03641 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A0FGR9 136 2.7e-07 Extended synaptotagmin-3 OS=Homo sapiens GN=ESYT3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14399 BP_3 136.88 17.08 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.144 BP_3 7.00 0.32 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14402 BP_3 4.00 0.40 774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14405 BP_3 105.13 2.15 2654 795017626 XP_011858919.1 264 4.2e-20 PREDICTED: uncharacterized protein LOC105556435, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14410 BP_3 31.81 0.44 3743 189237657 XP_001812177.1 794 2.1e-81 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 352 1.5e-31 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01536//PF01428 Adenosylmethionine decarboxylase//AN1-like Zinc finger GO:0006525//GO:0006560//GO:0008295//GO:0006597 arginine metabolic process//proline metabolic process//spermidine biosynthetic process//spermine biosynthetic process GO:0008270//GO:0004014 zinc ion binding//adenosylmethionine decarboxylase activity -- -- KOG3183 Predicted Zn-finger protein Cluster-8309.14411 BP_3 12.00 2.79 499 546674048 ERL85536.1 134 9.3e-06 hypothetical protein D910_02955, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14413 BP_3 2.00 2.05 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14414 BP_3 232.63 4.97 2547 270010170 EFA06618.1 643 4.6e-64 hypothetical protein TcasGA2_TC009536 [Tribolium castaneum] -- -- -- -- -- K11343 MRGBP MRG-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11343 Q9NV56 222 1.2e-16 MRG/MORF4L-binding protein OS=Homo sapiens GN=MRGBP PE=1 SV=1 PF07904//PF02724//PF02535 Chromatin modification-related protein EAF7//CDC45-like protein//ZIP Zinc transporter GO:0006355//GO:0055085//GO:0030001//GO:0006270 regulation of transcription, DNA-templated//transmembrane transport//metal ion transport//DNA replication initiation GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005634//GO:0043189 membrane//nucleus//H4/H2A histone acetyltransferase complex -- -- Cluster-8309.14415 BP_3 21.03 0.70 1745 91090662 XP_974317.1 1180 1.7e-126 PREDICTED: ubiquitin-like domain-containing CTD phosphatase 1 [Tribolium castaneum] -- -- -- -- -- K17618 UBLCP1 ubiquitin-like domain-containing CTD phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17618 Q6DI37 884 1.5e-93 Ubiquitin-like domain-containing CTD phosphatase 1 OS=Danio rerio GN=ublcp1 PE=2 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14417 BP_3 4.14 0.38 811 91092830 XP_968086.1 350 1.4e-30 PREDICTED: prefoldin subunit 6 [Tribolium castaneum]>gi|270003070|gb|EEZ99517.1| hypothetical protein TcasGA2_TC000098 [Tribolium castaneum] -- -- -- -- -- K04798 pfdB, PFDN6 prefoldin beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04798 Q9VW56 211 7.4e-16 Probable prefoldin subunit 6 OS=Drosophila melanogaster GN=CG7770 PE=2 SV=1 PF01920//PF12009 Prefoldin subunit//Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278//GO:0006457 RNA-dependent DNA replication//protein folding GO:0003964//GO:0051082 RNA-directed DNA polymerase activity//unfolded protein binding GO:0016272 prefoldin complex KOG3478 Prefoldin subunit 6, KE2 family Cluster-8309.14420 BP_3 44.78 1.40 1839 646717882 KDR20562.1 432 9.6e-40 Protein BTG1 [Zootermopsis nevadensis] 338224388 HM217837.1 575 0 Scylla paramamosain b-cell translocation protein-like mRNA, partial sequence K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 P53348 327 5.9e-29 Protein BTG1 OS=Bos taurus GN=BTG1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14423 BP_3 2.00 1.12 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14427 BP_3 753.00 54.23 961 642916726 XP_008192366.1 538 2.6e-52 PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum]>gi|642916728|ref|XP_008192372.1| PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1443 BP_3 70.91 1.08 3447 646708207 KDR14609.1 1334 4.6e-144 Lymphoid-specific helicase [Zootermopsis nevadensis] -- -- -- -- -- K19001 HELLS, DDM1 ATP-dependent DNA helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19001 Q9NRZ9 1194 3.3e-129 Lymphoid-specific helicase OS=Homo sapiens GN=HELLS PE=1 SV=1 PF00176//PF16094//PF04851//PF00270 SNF2 family N-terminal domain//Proteasome assembly chaperone 4//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0043248 proteasome assembly GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding GO:0005783 endoplasmic reticulum KOG0389 SNF2 family DNA-dependent ATPase Cluster-8309.14434 BP_3 49.34 1.28 2144 642935122 XP_008197897.1 1889 1.3e-208 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08999 508 7.1e-50 Latent-transforming growth factor beta-binding protein 2 OS=Mus musculus GN=Ltbp2 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.14437 BP_3 5.00 0.48 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1444 BP_3 2.59 1.84 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14440 BP_3 9.00 0.54 1088 642926052 XP_970129.2 646 8.7e-65 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 218 1.5e-16 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14442 BP_3 2.72 0.47 568 189238516 XP_971527.2 239 7.1e-18 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270009070|gb|EFA05518.1| hypothetical protein TcasGA2_TC015705 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14444 BP_3 17.40 0.33 2853 546670936 ERL83484.1 869 3.2e-90 hypothetical protein D910_00496 [Dendroctonus ponderosae]>gi|546677308|gb|ERL88165.1| hypothetical protein D910_05553 [Dendroctonus ponderosae] -- -- -- -- -- K14552 NAN1, UTP17, WDR75 NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) http://www.genome.jp/dbget-bin/www_bget?ko:K14552 Q6DFC6 351 1.5e-31 WD repeat-containing protein 75 OS=Xenopus laevis GN=wdr75 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1963 WD40 repeat protein Cluster-8309.14446 BP_3 19.00 1.67 839 642938019 XP_008199173.1 251 4.3e-19 PREDICTED: protein bride of sevenless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14448 BP_3 71.00 1.62 2399 478255263 ENN75492.1 1233 1.7e-132 hypothetical protein YQE_08041, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24738 366 2.3e-33 Protein bride of sevenless OS=Drosophila virilis GN=boss PE=3 SV=1 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.14449 BP_3 46.55 0.54 4438 675232298 CDU18069.1 185 1.0e-10 conserved Plasmodium protein, unknown function [Plasmodium yoelii] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00116 Cytochrome C oxidase subunit II, periplasmic domain GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0005507//GO:0004129 copper ion binding//cytochrome-c oxidase activity GO:0016020//GO:0045277 membrane//respiratory chain complex IV -- -- Cluster-8309.1445 BP_3 33.38 0.54 3285 546676649 ERL87613.1 536 1.5e-51 hypothetical protein D910_05004 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04428 Choline kinase N terminus -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.14453 BP_3 40.00 0.73 2940 167234210 NP_001107807.1 1900 9.2e-210 maxillopedia [Tribolium castaneum]>gi|270002809|gb|EEZ99256.1| proboscipedia [Tribolium castaneum] 347972356 XM_001688909.2 72 1.25745e-26 Anopheles gambiae str. PEST AGAP004648-PA (AgaP_AGAP004648) mRNA, complete cds K09302 HOX_2 homeobox protein HoxA/B2 http://www.genome.jp/dbget-bin/www_bget?ko:K09302 P31264 547 2.9e-54 Homeotic protein proboscipedia OS=Drosophila melanogaster GN=pb PE=2 SV=2 PF00507//PF07904//PF00046 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3//Chromatin modification-related protein EAF7//Homeobox domain GO:0006744//GO:0006355//GO:0006814//GO:0015992//GO:0055114//GO:0006120 ubiquinone biosynthetic process//regulation of transcription, DNA-templated//sodium ion transport//proton transport//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003677 NADH dehydrogenase (ubiquinone) activity//DNA binding GO:0005634//GO:0043189 nucleus//H4/H2A histone acetyltransferase complex -- -- Cluster-8309.14454 BP_3 73.80 1.71 2367 91091470 XP_973218.1 572 7.2e-56 PREDICTED: peroxisomal membrane protein 11C [Tribolium castaneum]>gi|270000949|gb|EEZ97396.1| hypothetical protein TcasGA2_TC011223 [Tribolium castaneum] -- -- -- -- -- K13353 PEX11C peroxin-11C http://www.genome.jp/dbget-bin/www_bget?ko:K13353 Q96HA9 264 1.5e-21 Peroxisomal membrane protein 11C OS=Homo sapiens GN=PEX11G PE=1 SV=1 PF05648 Peroxisomal biogenesis factor 11 (PEX11) GO:0016559 peroxisome fission -- -- GO:0005779 integral component of peroxisomal membrane -- -- Cluster-8309.14457 BP_3 479.53 6.14 4054 91089455 XP_976192.1 448 3.0e-41 PREDICTED: uncharacterized protein LOC656455 [Tribolium castaneum]>gi|270012567|gb|EFA09015.1| hypothetical protein TcasGA2_TC006723 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14459 BP_3 25.27 0.81 1791 642927339 XP_008195226.1 156 9.5e-08 PREDICTED: uncharacterized protein LOC103313529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14461 BP_3 10.00 0.56 1160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14474 BP_3 70.17 0.61 5856 270007859 EFA04307.1 4183 0.0e+00 hypothetical protein TcasGA2_TC014600 [Tribolium castaneum] 755881777 XM_005185855.2 73 7.00682e-27 PREDICTED: Musca domestica N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (LOC101896829), transcript variant X1, mRNA K03857 PIGA, GPI3 phosphatidylinositol glycan, class A http://www.genome.jp/dbget-bin/www_bget?ko:K03857 Q64323 1243 1.1e-134 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein OS=Mus musculus GN=Piga PE=2 SV=1 PF03790//PF02196//PF08288//PF00621 KNOX1 domain//Raf-like Ras-binding domain//PIGA (GPI anchor biosynthesis)//RhoGEF domain GO:0035023//GO:0007165//GO:0043087//GO:0006506 regulation of Rho protein signal transduction//signal transduction//regulation of GTPase activity//GPI anchor biosynthetic process GO:0003677//GO:0005057//GO:0005089 DNA binding//receptor signaling protein activity//Rho guanyl-nucleotide exchange factor activity GO:0005634 nucleus KOG1111 N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase Cluster-8309.14475 BP_3 244.14 2.14 5796 642924251 XP_008194216.1 3940 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] 755881777 XM_005185855.2 73 6.93459e-27 PREDICTED: Musca domestica N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (LOC101896829), transcript variant X1, mRNA K03857 PIGA, GPI3 phosphatidylinositol glycan, class A http://www.genome.jp/dbget-bin/www_bget?ko:K03857 Q64323 1243 1.1e-134 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein OS=Mus musculus GN=Piga PE=2 SV=1 PF03790//PF00621//PF08288//PF02196 KNOX1 domain//RhoGEF domain//PIGA (GPI anchor biosynthesis)//Raf-like Ras-binding domain GO:0007165//GO:0035023//GO:0006506//GO:0043087 signal transduction//regulation of Rho protein signal transduction//GPI anchor biosynthetic process//regulation of GTPase activity GO:0003677//GO:0005057//GO:0005089 DNA binding//receptor signaling protein activity//Rho guanyl-nucleotide exchange factor activity GO:0005634 nucleus KOG1111 N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase Cluster-8309.1448 BP_3 3.00 0.69 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14486 BP_3 13.00 0.55 1435 260784978 XP_002587540.1 1518 8.9e-166 hypothetical protein BRAFLDRAFT_282735 [Branchiostoma floridae]>gi|229272689|gb|EEN43551.1| hypothetical protein BRAFLDRAFT_282735 [Branchiostoma floridae] 655892251 XM_008250561.1 123 2.70406e-55 PREDICTED: Oryctolagus cuniculus 4-hydroxyphenylpyruvate dioxygenase (HPD), mRNA K00457 HPD, hppD 4-hydroxyphenylpyruvate dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00457 Q6TGZ5 1417 1.9e-155 4-hydroxyphenylpyruvate dioxygenase OS=Danio rerio GN=hpd PE=2 SV=1 PF00487 Fatty acid desaturase GO:0006558//GO:0009072//GO:0006629//GO:0006570//GO:0055114 L-phenylalanine metabolic process//aromatic amino acid family metabolic process//lipid metabolic process//tyrosine metabolic process//oxidation-reduction process GO:0046872//GO:0003868 metal ion binding//4-hydroxyphenylpyruvate dioxygenase activity -- -- KOG0638 4-hydroxyphenylpyruvate dioxygenase Cluster-8309.14488 BP_3 153.31 7.02 1344 332375084 AEE62683.1 674 6.1e-68 unknown [Dendroctonus ponderosae]>gi|478257085|gb|ENN77248.1| hypothetical protein YQE_06078, partial [Dendroctonus ponderosae]>gi|546683376|gb|ERL93198.1| hypothetical protein D910_10495 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PBF7 425 1.9e-40 ER membrane protein complex subunit 4 OS=Xenopus tropicalis GN=emc4 PE=2 SV=1 PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope KOG3318 Predicted membrane protein Cluster-8309.1449 BP_3 4.00 0.40 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14491 BP_3 1.00 6.33 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14493 BP_3 12.33 0.66 1196 270004865 EFA01313.1 772 2.4e-79 hypothetical protein TcasGA2_TC003245 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 482 4.1e-47 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14494 BP_3 21.00 1.25 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14496 BP_3 20.64 0.69 1736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14498 BP_3 4.00 0.32 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14499 BP_3 22.00 3.08 636 311739209 ADQ01809.1 550 6.9e-54 opsin protein [Uca pugilator] 311739208 HM765425.1 264 4.83228e-134 Celuca pugilator opsin protein (Rh1) mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 512 7.3e-51 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.145 BP_3 6.00 0.43 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14501 BP_3 3.00 0.35 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14505 BP_3 6.00 0.83 641 642936524 XP_008198472.1 330 2.3e-28 PREDICTED: transmembrane GTPase Marf [Tribolium castaneum]>gi|642936526|ref|XP_970147.2| PREDICTED: transmembrane GTPase Marf [Tribolium castaneum] -- -- -- -- -- K06030 MFN mitofusin http://www.genome.jp/dbget-bin/www_bget?ko:K06030 Q80U63 253 7.9e-21 Mitofusin-2 OS=Mus musculus GN=Mfn2 PE=1 SV=3 PF04548//PF05049//PF01926 AIG1 family//Interferon-inducible GTPase (IIGP)//50S ribosome-binding GTPase -- -- GO:0005525 GTP binding GO:0016020 membrane KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis Cluster-8309.14507 BP_3 88.38 1.86 2582 91088739 XP_975289.1 741 2.0e-75 PREDICTED: serine protease 33 [Tribolium castaneum]>gi|270012788|gb|EFA09236.1| serine protease P74 [Tribolium castaneum] -- -- -- -- -- K09631 HGFAC hepatocyte growth factor activator http://www.genome.jp/dbget-bin/www_bget?ko:K09631 Q6QNF4 302 6.6e-26 Hepatocyte growth factor activator OS=Canis familiaris GN=HGFAC PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3627 Trypsin Cluster-8309.14508 BP_3 413.62 6.77 3238 91088739 XP_975289.1 1117 6.3e-119 PREDICTED: serine protease 33 [Tribolium castaneum]>gi|270012788|gb|EFA09236.1| serine protease P74 [Tribolium castaneum] -- -- -- -- -- K09631 HGFAC hepatocyte growth factor activator http://www.genome.jp/dbget-bin/www_bget?ko:K09631 Q6QNF4 410 2.5e-38 Hepatocyte growth factor activator OS=Canis familiaris GN=HGFAC PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.14511 BP_3 180.88 4.86 2084 642925172 XP_001810693.2 1621 1.5e-177 PREDICTED: endoglucanase 5-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26221 879 6.6e-93 Endoglucanase E-4 OS=Thermobifida fusca GN=celD PE=1 SV=2 PF09204//PF00759 Bacterial self-protective colicin-like immunity//Glycosyl hydrolase family 9 GO:0005975//GO:0030153//GO:0006955 carbohydrate metabolic process//bacteriocin immunity//immune response GO:0015643//GO:0004553 toxic substance binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0019814 immunoglobulin complex -- -- Cluster-8309.14513 BP_3 131.54 2.41 2919 642916865 XP_008199533.1 1683 1.3e-184 PREDICTED: transcription termination factor 2 [Tribolium castaneum]>gi|270003081|gb|EEZ99528.1| hypothetical protein TcasGA2_TC000110 [Tribolium castaneum] -- -- -- -- -- K15173 TTF2 transcription termination factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15173 P34739 1220 2.7e-132 Transcription termination factor 2 OS=Drosophila melanogaster GN=lds PE=1 SV=2 PF02742//PF04851//PF00176//PF14532 Iron dependent repressor, metal binding and dimerisation domain//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//Sigma-54 interaction domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0046914//GO:0003677//GO:0016787//GO:0046983//GO:0008134//GO:0003676 ATP binding//transition metal ion binding//DNA binding//hydrolase activity//protein dimerization activity//transcription factor binding//nucleic acid binding GO:0005667 transcription factor complex KOG4439 RNA polymerase II transcription termination factor TTF2/lodestar, DEAD-box superfamily Cluster-8309.14515 BP_3 18.08 1.18 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14517 BP_3 1.00 1.62 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14518 BP_3 364.00 6.34 3060 499006075 XP_004535735.1 707 2.1e-71 PREDICTED: uncharacterized protein Nap1 [Ceratitis capitata] -- -- -- -- -- -- -- -- -- Q562D6 510 6.0e-50 Nef-associated protein 1 OS=Mus musculus GN=Nap1 PE=2 SV=2 PF05615 Tho complex subunit 7 GO:0006397 mRNA processing -- -- GO:0000445 THO complex part of transcription export complex KOG2942 Uncharacterized conserved protein Cluster-8309.14520 BP_3 36.91 0.53 3657 189237657 XP_001812177.1 794 2.0e-81 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 352 1.5e-31 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01428 AN1-like Zinc finger -- -- GO:0008270 zinc ion binding -- -- KOG3183 Predicted Zn-finger protein Cluster-8309.14522 BP_3 13.75 0.86 1059 478252105 ENN72536.1 402 1.7e-36 hypothetical protein YQE_10876, partial [Dendroctonus ponderosae]>gi|546683902|gb|ERL93650.1| hypothetical protein D910_10938 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14525 BP_3 26.01 0.31 4363 642935245 XP_008197928.1 1932 2.7e-213 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 308 1.20505e-157 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 830 6.7e-87 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF16990//PF05790//PF04110 Immunoglobulin domain//Carbohydrate binding module (family 35)//Immunoglobulin C2-set domain//Ubiquitin-like autophagy protein Apg12 GO:0000045//GO:0007155 autophagosome assembly//cell adhesion GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.14526 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14528 BP_3 323.65 12.27 1563 546684056 ERL93779.1 1614 7.1e-177 hypothetical protein D910_11065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P97535 312 2.8e-27 Phospholipase A1 member A OS=Rattus norvegicus GN=Pla1a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14530 BP_3 11.12 0.48 1416 759051754 XP_011335000.1 1135 2.3e-121 PREDICTED: uncharacterized protein LOC105277946 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14536 BP_3 52.83 0.64 4250 642910790 XP_008193412.1 598 1.3e-58 PREDICTED: COMM domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQ02 306 3.7e-26 COMM domain-containing protein 4 OS=Mus musculus GN=Commd4 PE=2 SV=1 PF10538//PF05434 Immunoreceptor tyrosine-based activation motif//TMEM9 GO:0007165 signal transduction -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.14539 BP_3 25.00 2.74 731 16903179 AAK61417.1 467 3.3e-44 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00367 phosphotransferase system, EIIB GO:0008643 carbohydrate transport GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex -- -- Cluster-8309.14543 BP_3 39.84 4.91 683 167444204 ABZ80663.1 352 6.8e-31 hypothetical antimicrobial peptide [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.14546 BP_3 18.00 2.42 650 799368377 AKA64754.1 459 2.5e-43 C-type lectin 4 [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14547 BP_3 364.00 16.49 1356 546673531 ERL85114.1 427 2.7e-39 hypothetical protein D910_02536 [Dendroctonus ponderosae] -- -- -- -- -- K02520 infC, MTIF3 translation initiation factor IF-3 http://www.genome.jp/dbget-bin/www_bget?ko:K02520 Q32KZ1 138 3.6e-07 Translation initiation factor IF-3, mitochondrial OS=Bos taurus GN=MTIF3 PE=2 SV=1 PF00707//PF00582//PF05198 Translation initiation factor IF-3, C-terminal domain//Universal stress protein family//Translation initiation factor IF-3, N-terminal domain GO:0006446//GO:0006413//GO:0006950 regulation of translational initiation//translational initiation//response to stress GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.14553 BP_3 114.62 6.66 1121 642910408 XP_008190721.1 355 5.0e-31 PREDICTED: UPF0235 protein C15orf40 homolog [Tribolium castaneum] -- -- -- -- -- K09131 K09131 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K09131 Q8WUR7 210 1.3e-15 UPF0235 protein C15orf40 OS=Homo sapiens GN=C15orf40 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3276 Uncharacterized conserved protein, contains YggU domain Cluster-8309.14556 BP_3 24.00 1.35 1147 -- -- -- -- -- 697070001 XM_009651886.1 1014 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- PF06021 Aralkyl acyl-CoA:amino acid N-acyltransferase GO:0042967 acyl-carrier-protein biosynthetic process GO:0047961 glycine N-acyltransferase activity GO:0005739 mitochondrion -- -- Cluster-8309.14557 BP_3 12.59 1.41 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1456 BP_3 853.00 45.57 1194 270297212 NP_001161917.1 591 2.3e-58 cuticular protein analogous to peritrophins 1-F precursor [Tribolium castaneum]>gi|268309010|gb|ACY95471.1| cuticular protein analogous to peritrophins 1-F [Tribolium castaneum]>gi|270010494|gb|EFA06942.1| hypothetical protein TcasGA2_TC009893 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.14561 BP_3 35.83 0.35 5244 768426896 XP_011554510.1 982 4.6e-103 PREDICTED: uncharacterized protein LOC105385776, partial [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q7M3K2 364 8.7e-33 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF01979//PF05485 Amidohydrolase family//THAP domain -- -- GO:0016787//GO:0003676 hydrolase activity//nucleic acid binding -- -- -- -- Cluster-8309.14565 BP_3 21.00 0.49 2358 -- -- -- -- -- 642917602 XM_008193054.1 49 6.14201e-14 PREDICTED: Tribolium castaneum glutamate receptor ionotropic, NMDA 2B (LOC660406), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14566 BP_3 75.09 1.26 3173 642929465 XP_974907.2 1251 1.8e-134 PREDICTED: armadillo repeat-containing protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K486 859 2.1e-90 Armadillo repeat-containing protein 6 homolog OS=Drosophila melanogaster GN=CG5721 PE=1 SV=1 PF00514//PF02671 Armadillo/beta-catenin-like repeat//Paired amphipathic helix repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- KOG4199 Uncharacterized conserved protein Cluster-8309.14567 BP_3 261.13 20.90 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q6NXE6 125 7.6e-06 Armadillo repeat-containing protein 6 OS=Homo sapiens GN=ARMC6 PE=1 SV=2 PF04098//PF01031 Rad52/22 family double-strand break repair protein//Dynamin central region GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0005525 GTP binding -- -- -- -- Cluster-8309.14574 BP_3 350.00 12.43 1649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.14575 BP_3 4.72 0.64 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1458 BP_3 72.19 1.11 3418 642922084 XP_008193010.1 357 8.9e-31 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270007256|gb|EFA03704.1| hypothetical protein TcasGA2_TC013809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 291 1.6e-24 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.14582 BP_3 48.00 1.37 1982 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14586 BP_3 1.00 0.40 410 478256132 ENN76331.1 225 2.2e-16 hypothetical protein YQE_07294, partial [Dendroctonus ponderosae]>gi|546675874|gb|ERL86979.1| hypothetical protein D910_04382 [Dendroctonus ponderosae] -- -- -- -- -- K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 192 5.9e-14 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14590 BP_3 16.95 0.66 1525 795009131 XP_011860215.1 397 9.1e-36 PREDICTED: putative nuclease HARBI1, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q6AZB8 158 1.9e-09 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14592 BP_3 107.71 3.13 1950 546683892 ERL93640.1 316 2.9e-26 hypothetical protein D910_10928, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13374 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14593 BP_3 1403.59 48.98 1673 546683892 ERL93640.1 316 2.5e-26 hypothetical protein D910_10928, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13374 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14594 BP_3 272.00 16.14 1104 478252093 ENN72524.1 145 1.1e-06 hypothetical protein YQE_10864, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06337 DUSP domain GO:0016579//GO:0006508 protein deubiquitination//proteolysis GO:0004843 ubiquitin-specific protease activity -- -- -- -- Cluster-8309.1460 BP_3 14.79 0.58 1517 642931180 XP_008196472.1 1244 5.5e-134 PREDICTED: pachytene checkpoint protein 2 homolog [Tribolium castaneum]>gi|270012108|gb|EFA08556.1| hypothetical protein TcasGA2_TC006211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P4W8 923 3.8e-98 Pachytene checkpoint protein 2 homolog OS=Xenopus tropicalis GN=trip13 PE=2 SV=1 PF10662//PF00910//PF07726//PF00005//PF04851//PF01637//PF02224//PF00437//PF00448//PF07724//PF06068//PF01443//PF05496//PF00931//PF02367//PF07931//PF02562//PF00004//PF07728//PF01695//PF00158 Ethanolamine utilisation - propanediol utilisation//RNA helicase//ATPase family associated with various cellular activities (AAA)//ABC transporter//Type III restriction enzyme, res subunit//Archaeal ATPase//Cytidylate kinase//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//AAA domain (Cdc48 subfamily)//TIP49 C-terminus//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Chloramphenicol phosphotransferase-like protein//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain GO:0006281//GO:0006810//GO:0006139//GO:0006614//GO:0006355//GO:0006576//GO:0006206//GO:0006310//GO:0002949 DNA repair//transport//nucleobase-containing compound metabolic process//SRP-dependent cotranslational protein targeting to membrane//regulation of transcription, DNA-templated//cellular biogenic amine metabolic process//pyrimidine nucleobase metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0016787//GO:0016740//GO:0005524//GO:0016887//GO:0004127//GO:0000166//GO:0043531//GO:0003677//GO:0003723//GO:0003678//GO:0003724//GO:0009378//GO:0005525 transcription factor binding//hydrolase activity//transferase activity//ATP binding//ATPase activity//cytidylate kinase activity//nucleotide binding//ADP binding//DNA binding//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity//GTP binding GO:0009379//GO:0005667//GO:0005657 Holliday junction helicase complex//transcription factor complex//replication fork KOG0744 AAA+-type ATPase Cluster-8309.14605 BP_3 29.19 2.58 838 642933664 XP_008197512.1 334 1.0e-28 PREDICTED: bifunctional coenzyme A synthase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K02318 COASY phosphopantetheine adenylyltransferase / dephospho-CoA kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02318 Q8MIR4 242 1.9e-19 Bifunctional coenzyme A synthase OS=Sus scrofa GN=COASY PE=1 SV=1 PF01121//PF03861 Dephospho-CoA kinase//ANTAR domain GO:0015940//GO:0015937 pantothenate biosynthetic process//coenzyme A biosynthetic process GO:0003723//GO:0005524//GO:0004140 RNA binding//ATP binding//dephospho-CoA kinase activity -- -- KOG3220 Similar to bacterial dephospho-CoA kinase Cluster-8309.14607 BP_3 272.12 4.42 3256 642922652 XP_008193262.1 1318 3.1e-142 PREDICTED: mediator of RNA polymerase II transcription subunit 15-like [Tribolium castaneum]>gi|270007150|gb|EFA03598.1| hypothetical protein TcasGA2_TC013685 [Tribolium castaneum] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 758 1.1e-78 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF09606//PF16987//PF02172 ARC105 or Med15 subunit of Mediator complex non-fungal//KIX domain//KIX domain GO:0006355//GO:0006357 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0003712 RNA polymerase II transcription cofactor activity//transcription cofactor activity GO:0005667//GO:0016592 transcription factor complex//mediator complex -- -- Cluster-8309.14608 BP_3 25.99 3.61 639 546681934 ERL91930.1 299 8.9e-25 hypothetical protein D910_09253 [Dendroctonus ponderosae] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 261 9.3e-22 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF16987//PF02172//PF09606 KIX domain//KIX domain//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003712//GO:0001104 transcription cofactor activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005667 mediator complex//transcription factor complex -- -- Cluster-8309.14609 BP_3 55.37 0.32 8753 642913944 XP_008201224.1 8365 0.0e+00 PREDICTED: leucine-rich repeat serine/threonine-protein kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TZM3 2222 5.2e-248 Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6 PF00023//PF07645//PF00071//PF08477//PF00069//PF07714//PF13606//PF13855//PF00025 Ankyrin repeat//Calcium-binding EGF domain//Ras family//Ras of Complex, Roc, domain of DAPkinase//Protein kinase domain//Protein tyrosine kinase//Ankyrin repeat//Leucine rich repeat//ADP-ribosylation factor family GO:0007264//GO:0006468 small GTPase mediated signal transduction//protein phosphorylation GO:0005524//GO:0005525//GO:0005509//GO:0005515//GO:0004672 ATP binding//GTP binding//calcium ion binding//protein binding//protein kinase activity -- -- -- -- Cluster-8309.1461 BP_3 5.00 3.96 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14613 BP_3 565.43 2.35 11870 270002715 EEZ99162.1 7123 0.0e+00 hypothetical protein TcasGA2_TC016161 [Tribolium castaneum] -- -- -- -- -- K06642 PRKDC DNA-dependent protein kinase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06642 Q9DEI1 1179 6.1e-127 DNA-dependent protein kinase catalytic subunit OS=Xenopus laevis GN=prkdc PE=2 SV=1 PF02260//PF00454//PF08163//PF08030 FATC domain//Phosphatidylinositol 3- and 4-kinase//NUC194 domain//Ferric reductase NAD binding domain GO:0016310//GO:0006303//GO:0009069//GO:0055114 phosphorylation//double-strand break repair via nonhomologous end joining//serine family amino acid metabolic process//oxidation-reduction process GO:0016491//GO:0005515//GO:0003677//GO:0005524//GO:0004677//GO:0016773 oxidoreductase activity//protein binding//DNA binding//ATP binding//DNA-dependent protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0891 DNA-dependent protein kinase Cluster-8309.14616 BP_3 27.98 0.41 3582 270007680 EFA04128.1 1175 1.3e-125 hypothetical protein TcasGA2_TC014371 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UFY4 313 4.9e-27 Radial spoke head protein 3 homolog A OS=Mus musculus GN=Rsph3a PE=2 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1337 N-methyltransferase Cluster-8309.14618 BP_3 967.69 61.76 1047 642936729 XP_008198556.1 318 9.1e-27 PREDICTED: uncharacterized protein LOC103314384 [Tribolium castaneum]>gi|270000961|gb|EEZ97408.1| hypothetical protein TcasGA2_TC011237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1462 BP_3 5.54 0.66 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14620 BP_3 227.00 9.64 1427 642914937 XP_008190449.1 1108 3.1e-118 PREDICTED: cytokine receptor-like factor 3 [Tribolium castaneum]>gi|270001393|gb|EEZ97840.1| hypothetical protein TcasGA2_TC000209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z2L7 466 3.5e-45 Cytokine receptor-like factor 3 OS=Mus musculus GN=Crlf3 PE=2 SV=1 PF16656//PF00076 Purple acid Phosphatase, N-terminal domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0003993//GO:0003676 metal ion binding//acid phosphatase activity//nucleic acid binding -- -- -- -- Cluster-8309.14623 BP_3 26.46 0.57 2541 546675694 ERL86836.1 661 3.7e-66 hypothetical protein D910_04239 [Dendroctonus ponderosae] -- -- -- -- -- K15865 CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15865 Q291H5 555 3.0e-55 Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Drosophila pseudoobscura pseudoobscura GN=GA19679 PE=3 SV=1 PF00919//PF05818 Uncharacterized protein family UPF0004//Enterobacterial TraT complement resistance protein GO:0046999//GO:0009451 regulation of conjugation//RNA modification GO:0051539//GO:0003824 4 iron, 4 sulfur cluster binding//catalytic activity GO:0019867 outer membrane KOG4355 Predicted Fe-S oxidoreductase Cluster-8309.14626 BP_3 18.40 1.01 1170 270000722 EEZ97169.1 479 2.2e-45 hypothetical protein TcasGA2_TC004356 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 P52735 284 3.7e-24 Guanine nucleotide exchange factor VAV2 OS=Homo sapiens GN=VAV2 PE=1 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.14632 BP_3 235.50 7.70 1766 642930318 XP_972929.2 2050 2.2e-227 PREDICTED: WD repeat-containing protein 20 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TBZ3 1084 9.5e-117 WD repeat-containing protein 20 OS=Homo sapiens GN=WDR20 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2394 WD40 protein DMR-N9 Cluster-8309.14633 BP_3 15.50 0.53 1708 642930318 XP_972929.2 1029 5.3e-109 PREDICTED: WD repeat-containing protein 20 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TBZ3 674 3.2e-69 WD repeat-containing protein 20 OS=Homo sapiens GN=WDR20 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2394 WD40 protein DMR-N9 Cluster-8309.14636 BP_3 2.00 0.43 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14638 BP_3 8.00 0.32 1483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11575 FhuF 2Fe-2S C-terminal domain -- -- GO:0051537 2 iron, 2 sulfur cluster binding -- -- -- -- Cluster-8309.14641 BP_3 26.68 1.36 1235 478261808 ENN80931.1 484 6.0e-46 hypothetical protein YQE_02637, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14642 BP_3 26.88 0.64 2317 646696193 KDR08640.1 625 5.1e-62 hypothetical protein L798_01542 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06783//PF08655 Uncharacterised protein family (UPF0239)//DASH complex subunit Ask1 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0016021//GO:0042729//GO:0072686 integral component of membrane//DASH complex//mitotic spindle -- -- Cluster-8309.14644 BP_3 4.00 0.31 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14647 BP_3 5.00 0.36 970 321470042 EFX81020.1 645 1.0e-64 hypothetical protein DAPPUDRAFT_318035 [Daphnia pulex] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9V7S5 486 1.1e-47 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00083//PF07690//PF03092 Sugar (and other) transporter//Major Facilitator Superfamily//BT1 family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.14648 BP_3 8.00 0.95 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1465 BP_3 38.16 1.57 1462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05091 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005852//GO:0005737//GO:0005840 eukaryotic translation initiation factor 3 complex//cytoplasm//ribosome -- -- Cluster-8309.14651 BP_3 15.00 0.71 1317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14652 BP_3 105.44 3.54 1728 189237912 XP_969631.2 1784 1.5e-196 PREDICTED: histone acetyltransferase KAT2A [Tribolium castaneum]>gi|270008022|gb|EFA04470.1| hypothetical protein TcasGA2_TC014774 [Tribolium castaneum] -- -- -- -- -- K06062 PCAF, KAT2, GCN5 histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06062 Q92830 1147 4.6e-124 Histone acetyltransferase KAT2A OS=Homo sapiens GN=KAT2A PE=1 SV=3 PF06466//PF13508//PF00583 PCAF (P300/CBP-associated factor) N-terminal domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967//GO:0044260//GO:0044238//GO:0006355 acyl-carrier-protein biosynthetic process//cellular macromolecule metabolic process//primary metabolic process//regulation of transcription, DNA-templated GO:0008080//GO:0004402 N-acetyltransferase activity//histone acetyltransferase activity GO:0005634//GO:0000123 nucleus//histone acetyltransferase complex KOG1472 Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins Cluster-8309.14654 BP_3 40.68 1.67 1464 676446104 XP_009050970.1 147 8.6e-07 hypothetical protein LOTGIDRAFT_159061 [Lottia gigantea]>gi|556109613|gb|ESO98265.1| hypothetical protein LOTGIDRAFT_159061 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14659 Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.14658 BP_3 26.00 0.74 1984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14659 BP_3 142.85 5.70 1500 642914621 XP_008190287.1 387 1.3e-34 PREDICTED: uncharacterized protein LOC103312158 [Tribolium castaneum]>gi|270002271|gb|EEZ98718.1| hypothetical protein TcasGA2_TC001264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14660 BP_3 114.00 8.73 921 642939617 XP_008193743.1 445 1.5e-41 PREDICTED: mitochondrial cardiolipin hydrolase-like [Tribolium castaneum]>gi|270016770|gb|EFA13216.1| hypothetical protein TcasGA2_TC010319 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2A8 151 7.6e-09 Mitochondrial cardiolipin hydrolase OS=Homo sapiens GN=PLD6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14665 BP_3 5.48 0.39 961 478256130 ENN76329.1 708 5.0e-72 hypothetical protein YQE_07292, partial [Dendroctonus ponderosae]>gi|546675872|gb|ERL86977.1| hypothetical protein D910_04380 [Dendroctonus ponderosae] -- -- -- -- -- K07556 ATPeAF2, ATPAF2, ATP12 ATP synthase mitochondrial F1 complex assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07556 Q1LZ96 431 2.7e-41 ATP synthase mitochondrial F1 complex assembly factor 2 OS=Bos taurus GN=ATPAF2 PE=2 SV=1 PF07542 ATP12 chaperone protein GO:0043461 proton-transporting ATP synthase complex assembly -- -- -- -- KOG3015 F1-ATP synthase assembly protein Cluster-8309.14666 BP_3 17.46 1.32 929 478256130 ENN76329.1 938 1.0e-98 hypothetical protein YQE_07292, partial [Dendroctonus ponderosae]>gi|546675872|gb|ERL86977.1| hypothetical protein D910_04380 [Dendroctonus ponderosae] -- -- -- -- -- K07556 ATPeAF2, ATPAF2, ATP12 ATP synthase mitochondrial F1 complex assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07556 Q1LZ96 572 1.2e-57 ATP synthase mitochondrial F1 complex assembly factor 2 OS=Bos taurus GN=ATPAF2 PE=2 SV=1 PF07542 ATP12 chaperone protein GO:0043461 proton-transporting ATP synthase complex assembly -- -- -- -- KOG3015 F1-ATP synthase assembly protein Cluster-8309.1467 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14670 BP_3 24.30 0.52 2555 478258505 ENN78580.1 1064 7.0e-113 hypothetical protein YQE_04948, partial [Dendroctonus ponderosae]>gi|546681354|gb|ERL91464.1| hypothetical protein D910_08794 [Dendroctonus ponderosae] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q5VTE6 582 2.2e-58 Protein angel homolog 2 OS=Homo sapiens GN=ANGEL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.14675 BP_3 28.12 0.47 3193 91083281 XP_974400.1 1638 2.4e-179 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|270007725|gb|EFA04173.1| hypothetical protein TcasGA2_TC014422 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.14676 BP_3 29.00 4.02 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14679 BP_3 60.63 1.46 2299 805784346 XP_012140054.1 553 1.1e-53 PREDICTED: DNA primase large subunit-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q84WJ2 302 5.9e-26 Probable DNA primase large subunit OS=Arabidopsis thaliana GN=At1g67320 PE=2 SV=2 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896 DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.14683 BP_3 220.87 5.46 2243 642928303 XP_008195525.1 1013 5.0e-107 PREDICTED: putative glycerol kinase 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19583 GK5 putative glycerol kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K19583 Q08D86 760 4.5e-79 Putative glycerol kinase 5 OS=Bos taurus GN=GK5 PE=2 SV=1 PF00370//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.14685 BP_3 30.86 1.01 1758 641681639 XP_008189542.1 961 4.2e-101 PREDICTED: uncharacterized protein LOC103311641 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.14686 BP_3 2.00 0.54 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14687 BP_3 11.00 8.84 346 685564024 XP_009213478.1 425 1.2e-39 PREDICTED: 40S ribosomal protein S27-like [Papio anubis] 694939145 XM_003312498.3 344 8.48167e-179 PREDICTED: Pan troglodytes 40S ribosomal protein S27 (LOC100614845), mRNA K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 P55833 353 1.1e-32 40S ribosomal protein S27 OS=Homarus americanus GN=RPS27 PE=3 SV=2 PF00527//PF01667 E7 protein, Early protein//Ribosomal protein S27 GO:0006412//GO:0042254//GO:0006355 translation//ribosome biogenesis//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0003735 DNA binding//transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome GO:0005667//GO:0005840//GO:0005622 transcription factor complex//ribosome//intracellular KOG1779 40s ribosomal protein S27 Cluster-8309.14688 BP_3 5.00 0.79 596 478256535 ENN76719.1 248 6.8e-19 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N823 192 8.7e-14 Zinc finger protein 611 OS=Homo sapiens GN=ZNF611 PE=2 SV=2 PF02025//PF00096//PF13465//PF05743//PF00628//PF16622//PF05191 Interleukin 5//Zinc finger, C2H2 type//Zinc-finger double domain//UEV domain//PHD-finger//zinc-finger C2H2-type//Adenylate kinase, active site lid GO:0040007//GO:0007165//GO:0006464//GO:0008283//GO:0006144//GO:0046034//GO:0006955//GO:0015031 growth//signal transduction//cellular protein modification process//cell proliferation//purine nucleobase metabolic process//ATP metabolic process//immune response//protein transport GO:0008083//GO:0005515//GO:0004017//GO:0005137//GO:0046872 growth factor activity//protein binding//adenylate kinase activity//interleukin-5 receptor binding//metal ion binding GO:0005895//GO:0005576 interleukin-5 receptor complex//extracellular region -- -- Cluster-8309.14692 BP_3 8.00 0.39 1271 826414684 XP_012522035.1 184 3.8e-11 PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414686|ref|XP_012522036.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414688|ref|XP_012522037.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414690|ref|XP_012522038.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414692|ref|XP_012522039.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414694|ref|XP_012522041.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14694 BP_3 1.00 1.27 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14695 BP_3 39.92 0.89 2462 91087901 XP_970608.1 817 2.9e-84 PREDICTED: protein cereblon [Tribolium castaneum]>gi|270012017|gb|EFA08465.1| hypothetical protein TcasGA2_TC006114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CF65 275 8.5e-23 Protein cereblon OS=Gallus gallus GN=CRBN PE=1 SV=1 PF02202//PF02190 Tachykinin family//ATP-dependent protease La (LON) substrate-binding domain GO:0006508//GO:0007217//GO:0007268//GO:0006510 proteolysis//tachykinin receptor signaling pathway//synaptic transmission//obsolete ATP-dependent proteolysis GO:0004176 ATP-dependent peptidase activity -- -- KOG1400 Predicted ATP-dependent protease PIL, contains LON domain Cluster-8309.14696 BP_3 25.60 0.61 2314 91087901 XP_970608.1 817 2.8e-84 PREDICTED: protein cereblon [Tribolium castaneum]>gi|270012017|gb|EFA08465.1| hypothetical protein TcasGA2_TC006114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CF65 275 8.0e-23 Protein cereblon OS=Gallus gallus GN=CRBN PE=1 SV=1 PF02202//PF02190 Tachykinin family//ATP-dependent protease La (LON) substrate-binding domain GO:0007268//GO:0006510//GO:0007217//GO:0006508 synaptic transmission//obsolete ATP-dependent proteolysis//tachykinin receptor signaling pathway//proteolysis GO:0004176 ATP-dependent peptidase activity -- -- KOG1400 Predicted ATP-dependent protease PIL, contains LON domain Cluster-8309.14698 BP_3 16.57 0.65 1527 642921939 XP_001809581.2 461 3.5e-43 PREDICTED: zinc finger protein 3 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.147 BP_3 2.00 1.29 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14700 BP_3 33.57 1.94 1124 642911268 XP_972818.2 1129 8.9e-121 PREDICTED: NAD-dependent protein deacylase [Tribolium castaneum] -- -- -- -- -- K11415 SIRT5, SIR2L5 NAD-dependent deacetylase sirtuin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11415 E9GD30 807 7.9e-85 NAD-dependent protein deacylase OS=Daphnia pulex GN=DAPPUDRAFT_195469 PE=3 SV=1 PF02146//PF00205//PF02233 Sir2 family//Thiamine pyrophosphate enzyme, central domain//NAD(P) transhydrogenase beta subunit GO:0046497//GO:0006769//GO:0055114 nicotinate nucleotide metabolic process//nicotinamide metabolic process//oxidation-reduction process GO:0008750//GO:0070403//GO:0050661//GO:0000287//GO:0030976 NAD(P)+ transhydrogenase (AB-specific) activity//NAD+ binding//NADP binding//magnesium ion binding//thiamine pyrophosphate binding GO:0016021 integral component of membrane KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family) Cluster-8309.14701 BP_3 125.90 2.42 2802 642917105 XP_008191117.1 1454 4.6e-158 PREDICTED: trimethylguanosine synthase isoform X3 [Tribolium castaneum] -- -- -- -- -- K14292 TGS1 trimethylguanosine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14292 Q923W1 629 8.7e-64 Trimethylguanosine synthase OS=Mus musculus GN=Tgs1 PE=1 SV=2 PF09452//PF01596//PF03602//PF05401//PF01795//PF05175//PF08241//PF09445//PF02005 ESCRT-I subunit Mvb12//O-methyltransferase//Conserved hypothetical protein 95//Nodulation protein S (NodS)//MraW methylase family//Methyltransferase small domain//Methyltransferase domain//RNA cap guanine-N2 methyltransferase//N2,N2-dimethylguanosine tRNA methyltransferase GO:0008033//GO:0009312//GO:0031167//GO:0032509//GO:0009451//GO:0009877//GO:0001510//GO:0009452//GO:0008152 tRNA processing//oligosaccharide biosynthetic process//rRNA methylation//endosome transport via multivesicular body sorting pathway//RNA modification//nodulation//RNA methylation//7-methylguanosine RNA capping//metabolic process GO:0004809//GO:0008168//GO:0008171//GO:0008757//GO:0043130//GO:0003723 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//O-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//ubiquitin binding//RNA binding GO:0000813 ESCRT I complex KOG2730 Methylase Cluster-8309.14702 BP_3 454.91 9.22 2671 642917105 XP_008191117.1 1454 4.3e-158 PREDICTED: trimethylguanosine synthase isoform X3 [Tribolium castaneum] -- -- -- -- -- K14292 TGS1 trimethylguanosine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14292 Q923W1 629 8.3e-64 Trimethylguanosine synthase OS=Mus musculus GN=Tgs1 PE=1 SV=2 PF02005//PF09445//PF03602//PF05175//PF09452//PF08241//PF01596 N2,N2-dimethylguanosine tRNA methyltransferase//RNA cap guanine-N2 methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain//ESCRT-I subunit Mvb12//Methyltransferase domain//O-methyltransferase GO:0008033//GO:0009451//GO:0032509//GO:0031167//GO:0008152//GO:0009452//GO:0001510 tRNA processing//RNA modification//endosome transport via multivesicular body sorting pathway//rRNA methylation//metabolic process//7-methylguanosine RNA capping//RNA methylation GO:0008168//GO:0004809//GO:0003723//GO:0043130//GO:0008171 methyltransferase activity//tRNA (guanine-N2-)-methyltransferase activity//RNA binding//ubiquitin binding//O-methyltransferase activity GO:0000813 ESCRT I complex KOG2730 Methylase Cluster-8309.14704 BP_3 182.00 10.35 1139 642934124 XP_008199287.1 1097 4.6e-117 PREDICTED: aurora kinase C [Tribolium castaneum]>gi|270014218|gb|EFA10666.1| IplI-aurora-like kinase [Tribolium castaneum] -- -- -- -- -- K11479 AURKB aurora kinase B http://www.genome.jp/dbget-bin/www_bget?ko:K11479 Q9VKN7 873 1.8e-92 Aurora kinase B OS=Drosophila melanogaster GN=ial PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004672//GO:0004674//GO:0016773 ATP binding//protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0580 Serine/threonine protein kinase Cluster-8309.14707 BP_3 15.00 0.40 2082 270001576 EEZ98023.1 814 5.5e-84 hypothetical protein TcasGA2_TC000423 [Tribolium castaneum] -- -- -- -- -- K06838 SLIT1 slit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06838 Q80X72 172 6.3e-11 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.14708 BP_3 2.00 0.34 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14709 BP_3 370.08 11.49 1844 332377013 AEE63646.1 1104 1.2e-117 unknown [Dendroctonus ponderosae]>gi|478253342|gb|ENN73703.1| hypothetical protein YQE_09700, partial [Dendroctonus ponderosae]>gi|546673935|gb|ERL85446.1| hypothetical protein D910_02865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VD07 261 2.7e-21 Neuronal membrane glycoprotein M6-a OS=Bos taurus GN=GPM6A PE=2 SV=1 PF01275 Myelin proteolipid protein (PLP or lipophilin) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.1471 BP_3 2.00 0.53 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14710 BP_3 3.62 0.51 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14714 BP_3 3.00 0.37 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14715 BP_3 144.84 1.29 5724 642921515 XP_008192902.1 1362 4.3e-147 PREDICTED: coiled-coil domain-containing protein 22 homolog, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16VW9 691 1.1e-70 Coiled-coil domain-containing protein 22 homolog OS=Aedes aegypti GN=AAEL009388 PE=3 SV=1 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.14716 BP_3 897.90 7.81 5831 642921515 XP_008192902.1 1362 4.4e-147 PREDICTED: coiled-coil domain-containing protein 22 homolog, partial [Tribolium castaneum] -- -- -- -- -- K09191 GTF3A general transcription factor IIIA http://www.genome.jp/dbget-bin/www_bget?ko:K09191 Q16VW9 691 1.2e-70 Coiled-coil domain-containing protein 22 homolog OS=Aedes aegypti GN=AAEL009388 PE=3 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.14717 BP_3 9.14 1.89 525 478251447 ENN71912.1 175 1.7e-10 hypothetical protein YQE_11449, partial [Dendroctonus ponderosae]>gi|546684895|gb|ERL94477.1| hypothetical protein D910_11754, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7PZ96 128 2.0e-06 Coiled-coil domain-containing protein 22 homolog OS=Anopheles gambiae GN=AGAP011801 PE=3 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14721 BP_3 1.00 0.43 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14723 BP_3 22.00 0.45 2673 546685488 ERL94986.1 1092 4.1e-116 hypothetical protein D910_12258 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14724 BP_3 185.24 20.23 733 642923172 XP_008193639.1 606 2.6e-60 PREDICTED: protein archease-like [Tribolium castaneum]>gi|270007591|gb|EFA04039.1| hypothetical protein TcasGA2_TC014269 [Tribolium castaneum] 847100090 XM_012956998.1 41 5.17666e-10 PREDICTED: Xenopus (Silurana) tropicalis zinc finger and BTB domain containing 8 opposite strand (zbtb8os), transcript variant X1, mRNA -- -- -- -- Q9VD92 461 6.9e-45 Protein archease-like OS=Drosophila melanogaster GN=CG6353 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4528 Uncharacterized conserved protein Cluster-8309.14726 BP_3 33.14 0.77 2365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0006814//GO:0006120//GO:0006744//GO:0015992//GO:0055114 sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//proton transport//oxidation-reduction process GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-8309.14728 BP_3 7.26 0.32 1382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1473 BP_3 48.00 2.60 1182 478255644 ENN75856.1 770 4.0e-79 hypothetical protein YQE_07585, partial [Dendroctonus ponderosae]>gi|546678128|gb|ERL88837.1| hypothetical protein D910_06219 [Dendroctonus ponderosae] -- -- -- -- -- K08865 PBK PDZ-binding kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08865 Q96KB5 494 1.6e-48 Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens GN=PBK PE=1 SV=3 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0192 Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs Cluster-8309.14730 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14731 BP_3 460.38 41.69 824 91076134 XP_970027.1 632 2.8e-63 PREDICTED: uncharacterized protein LOC658556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14733 BP_3 230.73 18.13 905 91086897 XP_970798.1 615 2.9e-61 PREDICTED: kxDL motif-containing protein CG10681 [Tribolium castaneum]>gi|270010480|gb|EFA06928.1| hypothetical protein TcasGA2_TC009878 [Tribolium castaneum] 571525050 XM_001122056.3 100 1.02724e-42 PREDICTED: Apis mellifera UPF0459 protein CG10681-like (LOC726308), mRNA -- -- -- -- Q9VTY4 332 7.7e-30 KxDL motif-containing protein CG10681 OS=Drosophila melanogaster GN=CG10681 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3443 Uncharacterized conserved protein Cluster-8309.14734 BP_3 4.27 1.32 447 91086897 XP_970798.1 252 1.7e-19 PREDICTED: kxDL motif-containing protein CG10681 [Tribolium castaneum]>gi|270010480|gb|EFA06928.1| hypothetical protein TcasGA2_TC009878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTY4 137 1.5e-07 KxDL motif-containing protein CG10681 OS=Drosophila melanogaster GN=CG10681 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14735 BP_3 2.00 0.45 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14736 BP_3 8.30 0.32 1527 91091194 XP_972244.1 768 8.7e-79 PREDICTED: superoxide dismutase [Cu-Zn] [Tribolium castaneum]>gi|270014236|gb|EFA10684.1| hypothetical protein TcasGA2_TC011675 [Tribolium castaneum] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 373 2.3e-34 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801//GO:0008152 oxidation-reduction process//superoxide metabolic process//metabolic process GO:0046872//GO:0016491 metal ion binding//oxidoreductase activity -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.14741 BP_3 3.00 0.60 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14742 BP_3 4.00 0.89 508 645028691 XP_008208512.1 312 2.2e-26 PREDICTED: uncharacterized protein LOC100115997 [Nasonia vitripennis] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q84TF0 176 5.3e-12 Aldo-keto reductase family 4 member C10 OS=Arabidopsis thaliana GN=AKR4C10 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.14750 BP_3 17.38 2.12 686 665816551 XP_008556999.1 157 2.8e-08 PREDICTED: fatty acid synthase-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P19096 123 1.0e-05 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.14754 BP_3 178.00 5.36 1893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14756 BP_3 41.98 13.16 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14759 BP_3 279.00 6.94 2229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1476 BP_3 217.09 6.76 1840 642937584 XP_008199108.1 1425 6.9e-155 PREDICTED: fidgetin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IHT0 1083 1.3e-116 Fidgetin-like protein 1 OS=Xenopus tropicalis GN=fignl1 PE=2 SV=1 PF07724//PF00004//PF06068//PF00158//PF05496//PF07728//PF01695 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//TIP49 C-terminus//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006310//GO:0006355//GO:0006281 DNA recombination//regulation of transcription, DNA-templated//DNA repair GO:0016887//GO:0009378//GO:0005524//GO:0003678//GO:0008134 ATPase activity//four-way junction helicase activity//ATP binding//DNA helicase activity//transcription factor binding GO:0005657//GO:0009379//GO:0005667 replication fork//Holliday junction helicase complex//transcription factor complex KOG0740 AAA+-type ATPase Cluster-8309.14760 BP_3 5.81 0.38 1037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14763 BP_3 20.17 0.69 1698 572270153 XP_006613077.1 1963 2.6e-217 PREDICTED: sodium channel protein para-like isoform X18 [Apis dorsata] 642910570 XM_008201785.1 644 0 PREDICTED: Tribolium castaneum paralytic A (Para), transcript variant X1, mRNA K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 Q99250 1173 4.4e-127 Sodium channel protein type 2 subunit alpha OS=Homo sapiens GN=SCN2A PE=1 SV=3 PF00520//PF01424 Ion transport protein//R3H domain GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216//GO:0003676 ion channel activity//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.14767 BP_3 63.59 0.77 4295 478249964 ENN70471.1 1379 3.5e-149 hypothetical protein YQE_12974, partial [Dendroctonus ponderosae] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q5BKQ4 455 2.0e-43 Inactive pancreatic lipase-related protein 1 OS=Mus musculus GN=Pnliprp1 PE=2 SV=2 PF08240//PF00107//PF01764 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase//Lipase (class 3) GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process -- -- -- -- -- -- Cluster-8309.14768 BP_3 1150.67 14.05 4240 270012898 EFA09346.1 2263 1.1e-251 hypothetical protein TcasGA2_TC001672 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q64425 822 5.5e-86 Pancreatic triacylglycerol lipase (Fragment) OS=Myocastor coypus GN=PNLIP PE=2 SV=1 PF08240//PF01764//PF00107 Alcohol dehydrogenase GroES-like domain//Lipase (class 3)//Zinc-binding dehydrogenase GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process -- -- -- -- -- -- Cluster-8309.14771 BP_3 68.00 1.80 2109 478250167 ENN70670.1 291 2.5e-23 hypothetical protein YQE_12615, partial [Dendroctonus ponderosae]>gi|478270480|gb|ENN83518.1| hypothetical protein YQE_00125, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBI2 154 7.8e-09 THAP domain-containing protein 4 OS=Bos taurus GN=THAP4 PE=2 SV=2 PF01064 Activin types I and II receptor domain GO:0016310//GO:0009069//GO:0007178 phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.14780 BP_3 37.50 0.80 2545 642939462 XP_008200412.1 1546 8.9e-169 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [Tribolium castaneum]>gi|270016524|gb|EFA12970.1| immune response deficient 5 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 666 4.0e-68 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.14781 BP_3 146.96 3.25 2469 642939462 XP_008200412.1 1546 8.6e-169 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [Tribolium castaneum]>gi|270016524|gb|EFA12970.1| immune response deficient 5 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 666 3.9e-68 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.14784 BP_3 30.03 0.70 2361 91077058 XP_968505.1 2308 3.6e-257 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] 665802087 XM_008550863.1 127 2.68479e-57 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 Q0V7M0 1916 4.2e-213 Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1 PF02985//PF10508//PF16006//PF01749//PF00514//PF11698//PF01602 HEAT repeat//Proteasome non-ATPase 26S subunit//Nucleolar and spindle-associated protein//Importin beta binding domain//Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region GO:0043248//GO:0006606//GO:0015031//GO:0006886//GO:0016192//GO:0000281//GO:0000226//GO:0015991//GO:0040001 proteasome assembly//protein import into nucleus//protein transport//intracellular protein transport//vesicle-mediated transport//mitotic cytokinesis//microtubule cytoskeleton organization//ATP hydrolysis coupled proton transport//establishment of mitotic spindle localization GO:0008565//GO:0016820//GO:0005515 protein transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0005737//GO:0030117//GO:0005819//GO:0005634//GO:0000221//GO:0005874 cytoplasm//membrane coat//spindle//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain//microtubule KOG0166 Karyopherin (importin) alpha Cluster-8309.14785 BP_3 87.03 3.40 1525 642912272 XP_008200632.1 555 4.4e-54 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CHN8 212 1.1e-15 Mannan-binding lectin serine protease 1 OS=Rattus norvegicus GN=Masp1 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.14787 BP_3 13.38 0.52 1542 189237377 XP_971339.2 309 1.5e-25 PREDICTED: X-linked interleukin-1 receptor accessory protein-like 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14790 BP_3 4.00 1.79 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14792 BP_3 420.00 36.00 854 91090518 XP_969863.1 621 5.4e-62 PREDICTED: splicing factor 3B subunit 6 [Tribolium castaneum]>gi|270013874|gb|EFA10322.1| hypothetical protein TcasGA2_TC012538 [Tribolium castaneum] 505828152 XM_004609330.1 91 9.73957e-38 PREDICTED: Sorex araneus splicing factor 3b, subunit 6, 14kDa (SF3B6), mRNA K12833 SF3B14 pre-mRNA branch site protein p14 http://www.genome.jp/dbget-bin/www_bget?ko:K12833 P59708 535 2.1e-53 Splicing factor 3B subunit 6 OS=Mus musculus GN=Sf3b6 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG0114 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.14794 BP_3 31.03 0.35 4545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08069 Ribosomal S13/S15 N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.14798 BP_3 2.00 0.51 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1480 BP_3 1.00 0.62 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14802 BP_3 264.00 8.28 1829 332374336 AEE62309.1 1357 5.3e-147 unknown [Dendroctonus ponderosae]>gi|478258016|gb|ENN78154.1| hypothetical protein YQE_05308, partial [Dendroctonus ponderosae]>gi|546682517|gb|ERL92440.1| hypothetical protein D910_09754 [Dendroctonus ponderosae] 826307347 XM_012649122.1 135 7.39515e-62 PREDICTED: Propithecus coquereli RAD51 recombinase (RAD51), mRNA K04482 RAD51 DNA repair protein RAD51 http://www.genome.jp/dbget-bin/www_bget?ko:K04482 Q06609 1348 2.4e-147 DNA repair protein RAD51 homolog 1 OS=Homo sapiens GN=RAD51 PE=1 SV=1 PF00006//PF00154//PF05625 ATP synthase alpha/beta family, nucleotide-binding domain//recA bacterial DNA recombination protein//PAXNEB protein GO:0009432//GO:0006281 SOS response//DNA repair GO:0003697//GO:0005524 single-stranded DNA binding//ATP binding GO:0033588 Elongator holoenzyme complex KOG1433 DNA repair protein RAD51/RHP55 Cluster-8309.14806 BP_3 12.82 0.43 1739 675376006 KFM68908.1 181 1.2e-10 hypothetical protein X975_14817, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14807 BP_3 9.00 1.83 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14808 BP_3 10.00 1.05 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14809 BP_3 17.00 0.41 2292 270016726 EFA13172.1 636 2.7e-63 hypothetical protein TcasGA2_TC001813 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NBX4 431 6.5e-41 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.1481 BP_3 3.00 0.42 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14813 BP_3 45.00 0.72 3297 91089087 XP_971707.1 1963 5.1e-217 PREDICTED: uncharacterized protein LOC660378 [Tribolium castaneum]>gi|270011517|gb|EFA07965.1| hypothetical protein TcasGA2_TC005547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXG1 131 5.7e-06 Zinc finger protein hangover OS=Drosophila melanogaster GN=hang PE=1 SV=3 PF05485//PF07776 THAP domain//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.14814 BP_3 155.86 2.24 3641 642932799 XP_008196988.1 4010 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X2 [Tribolium castaneum]>gi|270012453|gb|EFA08901.1| hypothetical protein TcasGA2_TC006604 [Tribolium castaneum] 642932798 XM_008198766.1 147 3.17052e-68 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1929 2.0e-214 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF14634//PF12861//PF17123//PF17122//PF00097//PF00637//PF13639 zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//Region in Clathrin and VPS//Ring finger domain GO:0006886//GO:0016567//GO:0016192 intracellular protein transport//protein ubiquitination//vesicle-mediated transport GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680//GO:0005622 anaphase-promoting complex//intracellular KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.14816 BP_3 42.77 0.56 3989 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1482 BP_3 2.00 0.46 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14820 BP_3 32.54 0.73 2431 642916580 XP_008191778.1 1413 2.2e-153 PREDICTED: heterogeneous nuclear ribonucleoprotein L [Tribolium castaneum] -- -- -- -- -- K13159 HNRNPL heterogeneous nuclear ribonucleoprotein L http://www.genome.jp/dbget-bin/www_bget?ko:K13159 P14866 442 3.6e-42 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens GN=HNRNPL PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1456 Heterogeneous nuclear ribonucleoprotein L (contains RRM repeats) Cluster-8309.14821 BP_3 13.00 0.36 2028 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07244 Surface antigen variable number repeat -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.14825 BP_3 42.16 0.98 2360 642918756 XP_008191570.1 1365 8.0e-148 PREDICTED: thymidylate synthase-like [Tribolium castaneum]>gi|270005647|gb|EFA02095.1| hypothetical protein TcasGA2_TC007732 [Tribolium castaneum] 674038954 XM_008826954.1 103 5.89182e-44 PREDICTED: Nannospalax galili thymidylate synthetase (Tyms), mRNA K00560 thyA, TYMS thymidylate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00560 P04818 1141 3.1e-123 Thymidylate synthase OS=Homo sapiens GN=TYMS PE=1 SV=3 PF02949//PF06385//PF00303 7tm Odorant receptor//Baculovirus LEF-11 protein//Thymidylate synthase GO:0032259//GO:0006235//GO:0006355//GO:0007608//GO:0006206//GO:0019058//GO:0007187//GO:0006231 methylation//dTTP biosynthetic process//regulation of transcription, DNA-templated//sensory perception of smell//pyrimidine nucleobase metabolic process//viral life cycle//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//dTMP biosynthetic process GO:0004799//GO:0004984//GO:0005549 thymidylate synthase activity//olfactory receptor activity//odorant binding GO:0016020 membrane KOG0673 Thymidylate synthase Cluster-8309.14826 BP_3 10.00 0.50 1255 751236503 XP_011172088.1 896 1.0e-93 PREDICTED: GTP cyclohydrolase 1 [Solenopsis invicta] 241989293 AK336271.1 231 2.1646e-115 Triticum aestivum cDNA, clone: SET3_K11, cultivar: Chinese Spring K01495 GCH1, folE GTP cyclohydrolase I http://www.genome.jp/dbget-bin/www_bget?ko:K01495 P48596 873 2.0e-92 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 PF14489 QueF-like protein GO:0008616 queuosine biosynthetic process GO:0033739 preQ1 synthase activity -- -- KOG2698 GTP cyclohydrolase I Cluster-8309.14827 BP_3 53.68 1.59 1916 642920753 XP_008192548.1 1430 1.9e-155 PREDICTED: probable asparagine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270005193|gb|EFA01641.1| hypothetical protein TcasGA2_TC007211 [Tribolium castaneum] -- -- -- -- -- K01893 NARS, asnS asparaginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01893 Q96I59 1064 2.1e-114 Probable asparagine--tRNA ligase, mitochondrial OS=Homo sapiens GN=NARS2 PE=1 SV=3 PF00587//PF00152//PF01409 tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N)//tRNA synthetases class II core domain (F) GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0005524//GO:0000166//GO:0000049//GO:0004812 ATP binding//nucleotide binding//tRNA binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm KOG0554 Asparaginyl-tRNA synthetase (mitochondrial) Cluster-8309.1483 BP_3 16.00 2.32 624 112180627 AAH70248.1 341 1.2e-29 TMSB4X protein, partial [Homo sapiens]>gi|112180667|gb|AAH92437.1| TMSB4X protein, partial [Homo sapiens] 18605541 BC022857.1 614 0 Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:4095465), partial cds K05764 TMSB4 thymosin, beta 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05764 P20065 231 2.7e-18 Thymosin beta-4 OS=Mus musculus GN=Tmsb4x PE=1 SV=1 PF01290//PF02205 Thymosin beta-4 family//WH2 motif GO:0030334//GO:0042989//GO:0007015//GO:0030168//GO:0001649//GO:0002576 regulation of cell migration//sequestering of actin monomers//actin filament organization//platelet activation//osteoblast differentiation//platelet degranulation GO:0003779//GO:0003785 actin binding//actin monomer binding GO:0005829//GO:0005634//GO:0005856//GO:0031093//GO:0005576 cytosol//nucleus//cytoskeleton//platelet alpha granule lumen//extracellular region -- -- Cluster-8309.14831 BP_3 31.70 1.39 1392 642932333 XP_008197070.1 234 6.6e-17 PREDICTED: uncharacterized protein LOC103314052 [Tribolium castaneum]>gi|270011613|gb|EFA08061.1| hypothetical protein TcasGA2_TC005657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.14832 BP_3 11.99 0.36 1877 642936481 XP_008198455.1 1480 3.0e-161 PREDICTED: beta-1,3-glucosyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13675 B3GALTL UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13675 Q8BHT6 1156 4.5e-125 Beta-1,3-glucosyltransferase OS=Mus musculus GN=B3galtl PE=2 SV=3 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.14834 BP_3 40.11 0.31 6536 642940052 XP_008200969.1 2913 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1596 1.5e-175 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF07728//PF01695//PF06068//PF05496//PF00439//PF00004//PF07724//PF00005//PF04851//PF00910 AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Bromodomain//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ABC transporter//Type III restriction enzyme, res subunit//RNA helicase GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0003724//GO:0009378//GO:0016887//GO:0005515//GO:0003723//GO:0005524//GO:0003678//GO:0003677//GO:0016787 RNA helicase activity//four-way junction helicase activity//ATPase activity//protein binding//RNA binding//ATP binding//DNA helicase activity//DNA binding//hydrolase activity GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.14835 BP_3 63.44 0.48 6635 642940052 XP_008200969.1 2767 6.2e-310 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULI0 1241 2.2e-134 ATPase family AAA domain-containing protein 2B OS=Homo sapiens GN=ATAD2B PE=1 SV=3 PF00005//PF04851//PF00910//PF01695//PF07728//PF05496//PF01057//PF06068//PF00004//PF00439//PF07724 ABC transporter//Type III restriction enzyme, res subunit//RNA helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Parvovirus non-structural protein NS1//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Bromodomain//AAA domain (Cdc48 subfamily) GO:0006310//GO:0006281//GO:0019079 DNA recombination//DNA repair//viral genome replication GO:0009378//GO:0003724//GO:0016887//GO:0005515//GO:0016787//GO:0003677//GO:0003678//GO:0005524//GO:0003723 four-way junction helicase activity//RNA helicase activity//ATPase activity//protein binding//hydrolase activity//DNA binding//DNA helicase activity//ATP binding//RNA binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.14837 BP_3 68.17 1.13 3210 270014457 EFA10905.1 278 1.2e-21 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.14839 BP_3 68.07 0.80 4384 675365924 KFM58826.1 1150 1.3e-122 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q96DM1 310 1.3e-26 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF01609//PF03184 Transposase DDE domain//DDE superfamily endonuclease GO:0006313 transposition, DNA-mediated GO:0003677//GO:0003676//GO:0004803 DNA binding//nucleic acid binding//transposase activity -- -- -- -- Cluster-8309.14840 BP_3 56.29 1.54 2050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14842 BP_3 34.65 0.53 3460 270015833 EFA12281.1 763 7.5e-78 hypothetical protein TcasGA2_TC005266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 289 2.8e-24 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00097//PF00665 Zinc finger, C3HC4 type (RING finger)//Integrase core domain GO:0015074 DNA integration GO:0046872 metal ion binding -- -- -- -- Cluster-8309.14845 BP_3 26.00 13.98 379 780006836 XP_011663261.1 153 4.5e-08 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 144 2.0e-08 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14847 BP_3 74.78 2.69 1631 546680075 ERL90427.1 374 4.5e-33 hypothetical protein D910_07776 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26005 167 1.9e-10 Ring-infected erythrocyte surface antigen (Fragment) OS=Plasmodium falciparum (isolate Palo Alto / Uganda) GN=RESA PE=3 SV=1 PF08061 P68HR (NUC004) repeat -- -- GO:0003724//GO:0016818//GO:0003712 RNA helicase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//transcription cofactor activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.1485 BP_3 2.86 0.37 661 751231159 XP_011169122.1 164 4.1e-09 PREDICTED: LOW QUALITY PROTEIN: cubilin [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14854 BP_3 1.00 0.40 412 149286942 ABR23370.1 318 3.6e-27 60S ribosomal protein L22 [Ornithodoros parkeri] -- -- -- -- -- K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 P50886 261 6.0e-22 60S ribosomal protein L22 OS=Xenopus laevis GN=rpl22 PE=2 SV=2 PF01776 Ribosomal L22e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3434 60S ribosomal protein L22 Cluster-8309.14855 BP_3 14.00 0.90 1039 478259391 ENN79287.1 225 5.5e-16 hypothetical protein YQE_04263, partial [Dendroctonus ponderosae]>gi|546679927|gb|ERL90309.1| hypothetical protein D910_07660 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14856 BP_3 776.00 11.14 3648 546682694 ERL92606.1 384 7.0e-34 hypothetical protein D910_09919 [Dendroctonus ponderosae] 642939363 XM_001807009.2 51 7.38038e-15 PREDICTED: Tribolium castaneum probable serine/threonine-protein kinase kinX (LOC100142294), mRNA -- -- -- -- -- -- -- -- PF07988//PF00379 LMSTEN motif//Insect cuticle protein GO:0006355 regulation of transcription, DNA-templated GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.14857 BP_3 38.00 9.00 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14859 BP_3 53.32 0.41 6485 91088309 XP_969421.1 1779 2.2e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 808 3.5e-84 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF02254//PF07307//PF07992//PF05834//PF00732//PF01266 GMC oxidoreductase//TrkA-N domain//Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0009234//GO:0006813//GO:0055114//GO:0016117 menaquinone biosynthetic process//potassium ion transport//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0016614//GO:0016705//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.14863 BP_3 227.38 3.18 3734 642936804 XP_008199623.1 2898 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 4.2e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF09726//PF02562//PF03836//PF00769//PF08702//PF00910//PF06156//PF01443//PF03796//PF07728//PF01695//PF08172//PF13851//PF00004 Transmembrane protein//PhoH-like protein//RasGAP C-terminus//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//RNA helicase//Protein of unknown function (DUF972)//Viral (Superfamily 1) RNA helicase//DnaB-like helicase C terminal domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//CASP C terminal//Growth-arrest specific micro-tubule binding//ATPase family associated with various cellular activities (AAA) GO:0030168//GO:0007264//GO:0006891//GO:0048870//GO:0006260//GO:0007165//GO:0051258 platelet activation//small GTPase mediated signal transduction//intra-Golgi vesicle-mediated transport//cell motility//DNA replication//signal transduction//protein polymerization GO:0030674//GO:0003724//GO:0008092//GO:0003723//GO:0003678//GO:0016887//GO:0005102//GO:0005524//GO:0005096 protein binding, bridging//RNA helicase activity//cytoskeletal protein binding//RNA binding//DNA helicase activity//ATPase activity//receptor binding//ATP binding//GTPase activator activity GO:0030173//GO:0005657//GO:0005577//GO:0005737//GO:0016021//GO:0019898//GO:0031514 integral component of Golgi membrane//replication fork//fibrinogen complex//cytoplasm//integral component of membrane//extrinsic component of membrane//motile cilium -- -- Cluster-8309.14864 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14868 BP_3 16.00 0.52 1789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14869 BP_3 255.48 2.25 5773 91092928 XP_971830.1 1416 2.4e-153 PREDICTED: ecto-NOX disulfide-thiol exchanger 2 [Tribolium castaneum]>gi|270003029|gb|EEZ99476.1| hypothetical protein TcasGA2_TC000049 [Tribolium castaneum] 642916932 XM_966737.2 142 3.03665e-65 PREDICTED: Tribolium castaneum ecto-NOX disulfide-thiol exchanger 2 (LOC660510), mRNA -- -- -- -- Q16206 812 1.1e-84 Ecto-NOX disulfide-thiol exchanger 2 OS=Homo sapiens GN=ENOX2 PE=1 SV=2 PF01576//PF07851//PF07716//PF15898//PF16367//PF00076//PF03938//PF04772 Myosin tail//TMPIT-like protein//Basic region leucine zipper//cGMP-dependent protein kinase interacting domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Outer membrane protein (OmpH-like)//Influenza B matrix protein 2 (BM2) GO:0006355//GO:0015992 regulation of transcription, DNA-templated//proton transport GO:0003774//GO:1901363//GO:0019901//GO:0003676//GO:0043565//GO:0051082//GO:0097159//GO:0003700 motor activity//heterocyclic compound binding//protein kinase binding//nucleic acid binding//sequence-specific DNA binding//unfolded protein binding//organic cyclic compound binding//transcription factor activity, sequence-specific DNA binding GO:0016459//GO:0016021//GO:0005667 myosin complex//integral component of membrane//transcription factor complex -- -- Cluster-8309.14870 BP_3 75.36 0.55 6847 91092928 XP_971830.1 955 8.1e-100 PREDICTED: ecto-NOX disulfide-thiol exchanger 2 [Tribolium castaneum]>gi|270003029|gb|EEZ99476.1| hypothetical protein TcasGA2_TC000049 [Tribolium castaneum] 642916932 XM_966737.2 142 3.60347e-65 PREDICTED: Tribolium castaneum ecto-NOX disulfide-thiol exchanger 2 (LOC660510), mRNA -- -- -- -- Q16206 476 1.2e-45 Ecto-NOX disulfide-thiol exchanger 2 OS=Homo sapiens GN=ENOX2 PE=1 SV=2 PF03938//PF04772//PF07716//PF16367//PF15898//PF00076//PF07851//PF01576 Outer membrane protein (OmpH-like)//Influenza B matrix protein 2 (BM2)//Basic region leucine zipper//RNA recognition motif//cGMP-dependent protein kinase interacting domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//TMPIT-like protein//Myosin tail GO:0006355//GO:0015992 regulation of transcription, DNA-templated//proton transport GO:0097159//GO:0051082//GO:0043565//GO:0003676//GO:0019901//GO:1901363//GO:0003774//GO:0003700 organic cyclic compound binding//unfolded protein binding//sequence-specific DNA binding//nucleic acid binding//protein kinase binding//heterocyclic compound binding//motor activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0016459//GO:0005667 integral component of membrane//myosin complex//transcription factor complex -- -- Cluster-8309.14871 BP_3 128.40 2.92 2412 91092928 XP_971830.1 2228 7.0e-248 PREDICTED: ecto-NOX disulfide-thiol exchanger 2 [Tribolium castaneum]>gi|270003029|gb|EEZ99476.1| hypothetical protein TcasGA2_TC000049 [Tribolium castaneum] 642916932 XM_966737.2 521 0 PREDICTED: Tribolium castaneum ecto-NOX disulfide-thiol exchanger 2 (LOC660510), mRNA -- -- -- -- Q16206 1165 5.2e-126 Ecto-NOX disulfide-thiol exchanger 2 OS=Homo sapiens GN=ENOX2 PE=1 SV=2 PF07716//PF16367//PF00076 Basic region leucine zipper//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006355 regulation of transcription, DNA-templated GO:1901363//GO:0003676//GO:0043565//GO:0097159//GO:0003700 heterocyclic compound binding//nucleic acid binding//sequence-specific DNA binding//organic cyclic compound binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.14873 BP_3 8.00 2.12 473 311739213 ADQ01811.1 515 5.9e-50 opsin protein [Uca pugilator] -- -- -- -- -- K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 419 3.3e-40 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.14874 BP_3 47.00 2.86 1085 321452097 EFX63569.1 1002 4.6e-106 hypothetical protein DAPPUDRAFT_307030 [Daphnia pulex] 472820477 JX422192.1 52 5.97461e-16 Sycophila sp. 2 BW-2013 ultraviolet sensitive opsin mRNA, partial cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25158 935 1.1e-99 Compound eye opsin BCRH2 OS=Hemigrapsus sanguineus PE=2 SV=1 PF08496//PF00001 Peptidase family S49 N-terminal//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0004252 G-protein coupled receptor activity//serine-type endopeptidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.14884 BP_3 511.62 6.96 3835 642922327 XP_008193114.1 254 8.8e-19 PREDICTED: uncharacterized protein LOC103312947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3B4 135 2.3e-06 Fas-associated death domain protein OS=Drosophila melanogaster GN=Fadd PE=1 SV=1 PF01335//PF00531 Death effector domain//Death domain GO:0042981//GO:0007165 regulation of apoptotic process//signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.14893 BP_3 91.49 1.00 4694 642920387 XP_008192325.1 229 8.5e-16 PREDICTED: uncharacterized protein LOC103312720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14894 BP_3 1315.91 24.75 2854 642920387 XP_008192325.1 296 8.8e-24 PREDICTED: uncharacterized protein LOC103312720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04690 YABBY protein GO:0007275 multicellular organismal development -- -- -- -- -- -- Cluster-8309.14895 BP_3 6534.59 151.19 2375 642920387 XP_008192325.1 296 7.3e-24 PREDICTED: uncharacterized protein LOC103312720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04690 YABBY protein GO:0007275 multicellular organismal development -- -- -- -- -- -- Cluster-8309.14899 BP_3 109.00 3.40 1835 91089769 XP_967094.1 1240 1.9e-133 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 654 7.2e-67 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.14900 BP_3 9.25 0.39 1437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08043 Xin repeat GO:0030036 actin cytoskeleton organization GO:0003779 actin binding GO:0030054 cell junction -- -- Cluster-8309.14901 BP_3 967.77 25.05 2154 642928781 XP_008195560.1 1027 1.1e-108 PREDICTED: uncharacterized protein LOC654941 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75475 193 2.4e-13 PC4 and SFRS1-interacting protein OS=Homo sapiens GN=PSIP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1904 Transcription coactivator Cluster-8309.14903 BP_3 1377.40 172.31 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14904 BP_3 1.00 8.38 248 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14905 BP_3 24.00 2.81 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14908 BP_3 165.54 13.89 866 642931457 XP_966478.2 520 2.8e-50 PREDICTED: ADP-ribosylation factor-like protein 6-interacting protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH07 151 7.1e-09 ADP-ribosylation factor-like protein 6-interacting protein 6 OS=Mus musculus GN=Arl6ip6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14909 BP_3 9.46 1.20 673 642931457 XP_966478.2 299 9.3e-25 PREDICTED: ADP-ribosylation factor-like protein 6-interacting protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14913 BP_3 119.00 2.89 2279 -- -- -- -- -- 768311753 CP010981.1 2258 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF01080//PF02724//PF02535 Presenilin//CDC45-like protein//ZIP Zinc transporter GO:0030001//GO:0055085//GO:0006270 metal ion transport//transmembrane transport//DNA replication initiation GO:0046873//GO:0004190 metal ion transmembrane transporter activity//aspartic-type endopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.14914 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14915 BP_3 22.00 0.36 3261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14916 BP_3 163.00 4.71 1959 642912037 XP_008199068.1 277 9.6e-22 PREDICTED: uncharacterized protein LOC103314522 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07955 Protein of unknown function (DUF1687) GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0005739 mitochondrion -- -- Cluster-8309.1492 BP_3 47.94 0.34 7091 270005459 EFA01907.1 5398 0.0e+00 hypothetical protein TcasGA2_TC007517 [Tribolium castaneum] 676475132 XM_009062126.1 77 5.07352e-29 Lottia gigantea hypothetical protein partial mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q63164 4150 0.0e+00 Dynein heavy chain 1, axonemal OS=Rattus norvegicus GN=Dnah1 PE=2 SV=2 PF03152//PF01733//PF03028//PF06810 Ubiquitin fusion degradation protein UFD1//Nucleoside transporter//Dynein heavy chain and region D6 of dynein motor//Phage minor structural protein GP20 GO:0007017//GO:0006511//GO:0007018//GO:0015858//GO:0006810 microtubule-based process//ubiquitin-dependent protein catabolic process//microtubule-based movement//nucleoside transport//transport GO:0005337//GO:0005198//GO:0003777 nucleoside transmembrane transporter activity//structural molecule activity//microtubule motor activity GO:0016021//GO:0030286//GO:0005874 integral component of membrane//dynein complex//microtubule -- -- Cluster-8309.14921 BP_3 200.01 0.87 11381 642923391 XP_008193728.1 8360 0.0e+00 PREDICTED: protein still life, isoform SIF type 1 [Tribolium castaneum] 642923390 XM_008195506.1 1845 0 PREDICTED: Tribolium castaneum protein still life, isoform SIF type 1 (LOC662876), mRNA -- -- -- -- P91621 6407 0.0e+00 Protein still life, isoform SIF type 1 OS=Drosophila melanogaster GN=sif PE=2 SV=2 PF05453//PF00595//PF00621//PF02724//PF13180//PF02196 BmTXKS1/BmP02 toxin family//PDZ domain (Also known as DHR or GLGF)//RhoGEF domain//CDC45-like protein//PDZ domain//Raf-like Ras-binding domain GO:0006810//GO:0006270//GO:0009405//GO:0007165//GO:0035023//GO:0043087 transport//DNA replication initiation//pathogenesis//signal transduction//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005057//GO:0008200//GO:0005089 protein binding//receptor signaling protein activity//ion channel inhibitor activity//Rho guanyl-nucleotide exchange factor activity GO:0005576 extracellular region KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases Cluster-8309.14922 BP_3 76.00 4.19 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14926 BP_3 82.89 4.81 1122 478253294 ENN73663.1 328 6.7e-28 hypothetical protein YQE_09740, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- H3BPM6 142 1.0e-07 MKRN2 opposite strand protein OS=Homo sapiens GN=MKRN2OS PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14928 BP_3 73.36 0.83 4533 642919931 XP_974732.3 1610 6.0e-176 PREDICTED: tetratricopeptide repeat protein 5-like [Tribolium castaneum]>gi|270005358|gb|EFA01806.1| hypothetical protein TcasGA2_TC007407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BK48 883 4.9e-93 Tetratricopeptide repeat protein 5 OS=Rattus norvegicus GN=Ttc5 PE=2 SV=1 PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14929 BP_3 360.56 4.07 4557 642919931 XP_974732.3 1610 6.0e-176 PREDICTED: tetratricopeptide repeat protein 5-like [Tribolium castaneum]>gi|270005358|gb|EFA01806.1| hypothetical protein TcasGA2_TC007407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BK48 883 5.0e-93 Tetratricopeptide repeat protein 5 OS=Rattus norvegicus GN=Ttc5 PE=2 SV=1 PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14932 BP_3 11.59 0.36 1829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14934 BP_3 130.00 3.41 2127 91092326 XP_970342.1 1999 2.2e-221 PREDICTED: NAD-dependent protein deacetylase sirtuin-7 [Tribolium castaneum]>gi|270015701|gb|EFA12149.1| hypothetical protein TcasGA2_TC002298 [Tribolium castaneum] -- -- -- -- -- K11417 SIRT7, SIR2L7 NAD-dependent deacetylase sirtuin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11417 Q9VAQ1 1120 7.6e-121 NAD-dependent protein deacetylase Sirt7 OS=Drosophila melanogaster GN=Sirt7 PE=1 SV=2 PF02146//PF02263 Sir2 family//Guanylate-binding protein, N-terminal domain -- -- GO:0005525//GO:0070403//GO:0003924 GTP binding//NAD+ binding//GTPase activity -- -- KOG1905 Class IV sirtuins (SIR2 family) Cluster-8309.14937 BP_3 5.26 0.49 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14938 BP_3 1.00 0.33 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14940 BP_3 4.00 0.31 904 -- -- -- -- -- 185050467 AP009016.1 58 2.28478e-19 Bombyx mori genomic DNA, chromosome 20, BAC clone:060O24, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14944 BP_3 36.48 0.52 3662 91088445 XP_968690.1 1072 1.2e-113 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q5ZHY5 775 1.3e-80 STIP1 homology and U box-containing protein 1 OS=Gallus gallus GN=STUB1 PE=2 SV=1 PF04564//PF13181//PF02465//PF07497//PF00515//PF13176//PF04658//PF13414//PF00520 U-box domain//Tetratricopeptide repeat//Flagellar hook-associated protein 2 N-terminus//Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//TAFII55 protein conserved region//TPR repeat//Ion transport protein GO:0055085//GO:0016567//GO:0006353//GO:0006811//GO:0006367 transmembrane transport//protein ubiquitination//DNA-templated transcription, termination//ion transport//transcription initiation from RNA polymerase II promoter GO:0003723//GO:0005515//GO:0004842//GO:0005216 RNA binding//protein binding//ubiquitin-protein transferase activity//ion channel activity GO:0000151//GO:0009424//GO:0016020//GO:0005669 ubiquitin ligase complex//bacterial-type flagellum hook//membrane//transcription factor TFIID complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.14945 BP_3 43.65 1.90 1397 332372726 AEE61505.1 843 1.6e-87 unknown [Dendroctonus ponderosae]>gi|546679246|gb|ERL89740.1| hypothetical protein D910_07101 [Dendroctonus ponderosae] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 503 1.8e-49 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF13174//PF02465//PF13181//PF13414//PF04658//PF13176//PF07497//PF00515//PF13371 Tetratricopeptide repeat//Flagellar hook-associated protein 2 N-terminus//Tetratricopeptide repeat//TPR repeat//TAFII55 protein conserved region//Tetratricopeptide repeat//Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006353//GO:0006367 DNA-templated transcription, termination//transcription initiation from RNA polymerase II promoter GO:0003723//GO:0005515 RNA binding//protein binding GO:0009424//GO:0005669 bacterial-type flagellum hook//transcription factor TFIID complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.14947 BP_3 47.38 2.20 1332 642931818 XP_008196746.1 1127 1.8e-120 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] 551546037 XM_005760895.1 51 2.65098e-15 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 861 5.2e-91 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF00764//PF07722//PF02269//PF02568//PF01507//PF00733 Arginosuccinate synthase//Peptidase C26//Transcription initiation factor IID, 18kD subunit//Thiamine biosynthesis protein (ThiI)//Phosphoadenosine phosphosulfate reductase family//Asparagine synthase GO:0008152//GO:0006526//GO:0006529//GO:0006531//GO:0006366//GO:0006560//GO:0006522//GO:0006541//GO:0008033 metabolic process//arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//transcription from RNA polymerase II promoter//proline metabolic process//alanine metabolic process//glutamine metabolic process//tRNA processing GO:0004810//GO:0003824//GO:0005524//GO:0016787//GO:0004055//GO:0004066 tRNA adenylyltransferase activity//catalytic activity//ATP binding//hydrolase activity//argininosuccinate synthase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG1622 GMP synthase Cluster-8309.14950 BP_3 19.00 0.35 2893 478249789 ENN70296.1 680 2.7e-68 hypothetical protein YQE_12807, partial [Dendroctonus ponderosae]>gi|546682887|gb|ERL92773.1| hypothetical protein D910_10081 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CWR2 188 1.2e-12 Histone-lysine N-methyltransferase SMYD3 OS=Mus musculus GN=Smyd3 PE=2 SV=1 PF08918//PF13414//PF00856 PhoQ Sensor//TPR repeat//SET domain GO:0000160//GO:0016310//GO:0018106 phosphorelay signal transduction system//phosphorylation//peptidyl-histidine phosphorylation GO:0005524//GO:0005515//GO:0004673//GO:0046872 ATP binding//protein binding//protein histidine kinase activity//metal ion binding GO:0009365//GO:0016020 protein histidine kinase complex//membrane -- -- Cluster-8309.14953 BP_3 281.00 15.60 1160 642929851 XP_008196001.1 185 2.7e-11 PREDICTED: uncharacterized protein LOC100142022 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF13965//PF07821 Oxaloacetate decarboxylase, gamma chain//dsRNA-gated channel SID-1//Alpha-amylase C-terminal beta-sheet domain GO:0005982//GO:0005985//GO:0006560//GO:0006814//GO:0071436//GO:0006090//GO:0033227//GO:0005975//GO:0006525//GO:0015931 starch metabolic process//sucrose metabolic process//proline metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process//dsRNA transport//carbohydrate metabolic process//arginine metabolic process//nucleobase-containing compound transport GO:0005509//GO:0051033//GO:0004556//GO:0015081//GO:0008948 calcium ion binding//RNA transmembrane transporter activity//alpha-amylase activity//sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.14955 BP_3 10.00 0.53 1209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-8309.14957 BP_3 35.00 0.44 4089 91086367 XP_974595.1 889 2.2e-92 PREDICTED: ankyrin repeat family A protein 2-like [Tribolium castaneum] -- -- -- -- -- K13352 PEX11B peroxin-11B http://www.genome.jp/dbget-bin/www_bget?ko:K13352 Q9ULH0 194 3.5e-13 Kinase D-interacting substrate of 220 kDa OS=Homo sapiens GN=KIDINS220 PE=1 SV=3 PF02931//PF13606//PF00023//PF02932//PF05648 Neurotransmitter-gated ion-channel ligand binding domain//Ankyrin repeat//Ankyrin repeat//Neurotransmitter-gated ion-channel transmembrane region//Peroxisomal biogenesis factor 11 (PEX11) GO:0016559//GO:0006811//GO:0006810 peroxisome fission//ion transport//transport GO:0005230//GO:0005515 extracellular ligand-gated ion channel activity//protein binding GO:0016020//GO:0005779 membrane//integral component of peroxisomal membrane -- -- Cluster-8309.14958 BP_3 11.00 0.46 1435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14963 BP_3 3.00 0.48 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14968 BP_3 77.81 0.89 4486 91076588 XP_968186.1 1366 1.2e-147 PREDICTED: transmembrane protein 194A [Tribolium castaneum]>gi|270002381|gb|EEZ98828.1| hypothetical protein TcasGA2_TC004435 [Tribolium castaneum] 642912650 XM_963240.2 181 4.9214e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K12198 CHMP5, VPS60 charged multivesicular body protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12198 Q9VVI9 706 1.6e-72 Charged multivesicular body protein 5 OS=Drosophila melanogaster GN=Vps60 PE=1 SV=2 PF04632//PF04111//PF16326//PF05531//PF01920//PF04871//PF03357//PF02252//PF00091//PF00462//PF07544 Fusaric acid resistance protein family//Autophagy protein Apg6//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Prefoldin subunit//Uso1 / p115 like vesicle tethering protein, C terminal region//Snf7//Proteasome activator pa28 beta subunit//Tubulin/FtsZ family, GTPase domain//Glutaredoxin//RNA polymerase II transcription mediator complex subunit 9 GO:0006118//GO:0006357//GO:0007034//GO:0015031//GO:0006914//GO:0006810//GO:0006886//GO:0045454//GO:0006457 obsolete electron transport//regulation of transcription from RNA polymerase II promoter//vacuolar transport//protein transport//autophagy//transport//intracellular protein transport//cell redox homeostasis//protein folding GO:0051082//GO:0008565//GO:0003924//GO:0009055//GO:0015035//GO:0001104//GO:0003677 unfolded protein binding//protein transporter activity//GTPase activity//electron carrier activity//protein disulfide oxidoreductase activity//RNA polymerase II transcription cofactor activity//DNA binding GO:0016272//GO:0005737//GO:0019028//GO:0008537//GO:0016020//GO:0016592//GO:0005886 prefoldin complex//cytoplasm//viral capsid//proteasome activator complex//membrane//mediator complex//plasma membrane KOG1655 Protein involved in vacuolar protein sorting Cluster-8309.14970 BP_3 10.78 0.49 1345 642928086 XP_008200150.1 1204 2.1e-129 PREDICTED: cleavage and polyadenylation specificity factor 73 [Tribolium castaneum] 642928085 XM_008201928.1 158 8.84639e-75 PREDICTED: Tribolium castaneum cleavage and polyadenylation specificity factor 73 (LOC103314846), mRNA K14403 CPSF3, YSH1 cleavage and polyadenylation specificity factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14403 Q9VE51 718 2.0e-74 Cleavage and polyadenylation specificity factor 73 OS=Drosophila melanogaster GN=Cpsf73 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1137 mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit) Cluster-8309.14972 BP_3 106.84 4.65 1400 478251660 ENN72114.1 644 1.9e-64 hypothetical protein YQE_11173, partial [Dendroctonus ponderosae]>gi|478262747|gb|ENN81278.1| hypothetical protein YQE_02314, partial [Dendroctonus ponderosae]>gi|546680914|gb|ERL91088.1| hypothetical protein D910_08430 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VMA0 249 5.0e-20 Non-structural maintenance of chromosomes element 1 homolog OS=Drosophila melanogaster GN=CG11329 PE=1 SV=1 PF09494//PF00130//PF13639//PF12678//PF12861//PF07574 Slx4 endonuclease//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ring finger domain//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//Nse1 non-SMC component of SMC5-6 complex GO:0006260//GO:0035556//GO:0006308//GO:0006281//GO:0016567 DNA replication//intracellular signal transduction//DNA catabolic process//DNA repair//protein ubiquitination GO:0008270//GO:0005515//GO:0017108//GO:0004842 zinc ion binding//protein binding//5'-flap endonuclease activity//ubiquitin-protein transferase activity GO:0033557//GO:0030915//GO:0005634//GO:0005680 Slx1-Slx4 complex//Smc5-Smc6 complex//nucleus//anaphase-promoting complex -- -- Cluster-8309.14973 BP_3 5.19 0.45 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14974 BP_3 46.27 0.89 2804 642929061 XP_008195675.1 411 4.0e-37 PREDICTED: metastasis suppressor protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14975 BP_3 535.24 4.42 6134 642929059 XP_008195674.1 2113 3.8e-234 PREDICTED: A-agglutinin anchorage subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9S0 859 4.1e-90 MTSS1-like protein OS=Mus musculus GN=Mtss1l PE=1 SV=1 PF14980//PF02205//PF08397 TIP39 peptide//WH2 motif//IRSp53/MIM homology domain GO:0007218//GO:0007009 neuropeptide signaling pathway//plasma membrane organization GO:0003779 actin binding GO:0005576 extracellular region -- -- Cluster-8309.14976 BP_3 116.51 8.95 919 642930190 XP_008196293.1 167 2.6e-09 PREDICTED: uncharacterized protein LOC103313824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14978 BP_3 20.00 29.14 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1498 BP_3 37.22 0.88 2337 642922875 XP_008200434.1 935 5.8e-98 PREDICTED: uncharacterized protein LOC103314918 [Tribolium castaneum]>gi|270006561|gb|EFA03009.1| hypothetical protein TcasGA2_TC010432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8K0R7 132 3.1e-06 Zinc finger protein 839 OS=Homo sapiens GN=ZNF839 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14980 BP_3 3.00 0.36 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14982 BP_3 29.00 1.35 1330 642936215 XP_008198351.1 1428 2.2e-155 PREDICTED: diuretic hormone receptor-like isoform X4 [Tribolium castaneum] 158294218 XM_315466.4 68 9.38618e-25 Anopheles gambiae str. PEST AGAP005464-PA (GPRDIH1) mRNA, complete cds K04578 CRHR1 corticotropin releasing hormone receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04578 P35464 907 2.4e-96 Diuretic hormone receptor OS=Manduca sexta PE=2 SV=1 PF00002//PF02793 7 transmembrane receptor (Secretin family)//Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.14988 BP_3 155.01 2.73 3033 189235075 XP_966626.2 2795 0.0e+00 PREDICTED: sorting nexin-14-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5W7 985 4.9e-105 Sorting nexin-14 OS=Homo sapiens GN=SNX14 PE=1 SV=3 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.14989 BP_3 126.00 5.67 1362 91094199 XP_971496.1 1166 5.5e-125 PREDICTED: probable DNA-directed RNA polymerase III subunit RPC6 [Tribolium castaneum]>gi|270011207|gb|EFA07655.1| hypothetical protein TcasGA2_TC030601 [Tribolium castaneum] -- -- -- -- -- K03025 RPC6, POLR3F DNA-directed RNA polymerase III subunit RPC6 http://www.genome.jp/dbget-bin/www_bget?ko:K03025 Q9VD25 724 4.1e-75 Probable DNA-directed RNA polymerase III subunit RPC6 OS=Drosophila melanogaster GN=CG5380 PE=2 SV=1 PF05158 RNA polymerase Rpc34 subunit GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3233 RNA polymerase III, subunit C34 Cluster-8309.14994 BP_3 97.62 3.49 1640 478252125 ENN72556.1 881 7.4e-92 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 299 9.3e-26 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.14998 BP_3 8308.74 174.71 2584 21218350 AAM44045.1 1977 9.5e-219 arylphorin-like hexamerin [Apriona germari] -- -- -- -- -- -- -- -- -- Q17127 1104 6.7e-119 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14999 BP_3 7.00 0.75 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15 BP_3 2.00 0.70 429 533174851 XP_005400816.1 520 1.4e-50 PREDICTED: 60S ribosomal protein L31 [Chinchilla lanigera] 153252117 NM_000993.4 429 0 Homo sapiens ribosomal protein L31 (RPL31), transcript variant 1, mRNA K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 P62899 514 2.9e-51 60S ribosomal protein L31 OS=Homo sapiens GN=RPL31 PE=1 SV=1 PF01198//PF03852 Ribosomal protein L31e//DNA mismatch endonuclease Vsr GO:0006298//GO:0042254//GO:0006412 mismatch repair//ribosome biogenesis//translation GO:0004519//GO:0003735 endonuclease activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0893 60S ribosomal protein L31 Cluster-8309.15002 BP_3 32.09 0.78 2278 332373404 AEE61843.1 1012 6.6e-107 unknown [Dendroctonus ponderosae] 442615894 NM_132446.4 93 2.05885e-38 Drosophila melanogaster CG42339 (CG42339), transcript variant B, mRNA -- -- -- -- Q8IVN8 265 1.1e-21 Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Homo sapiens GN=SBSPON PE=1 SV=2 PF01033 Somatomedin B domain GO:0006955//GO:0007165 immune response//signal transduction GO:0005044//GO:0030247 scavenger receptor activity//polysaccharide binding -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.15003 BP_3 12143.91 229.43 2843 332373404 AEE61843.1 1354 1.8e-146 unknown [Dendroctonus ponderosae] 442615894 NM_132446.4 93 2.57574e-38 Drosophila melanogaster CG42339 (CG42339), transcript variant B, mRNA -- -- -- -- Q3UPR9 349 2.6e-31 Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Mus musculus GN=Sbspon PE=2 SV=1 PF01033 Somatomedin B domain GO:0006955//GO:0007165 immune response//signal transduction GO:0030247//GO:0005044 polysaccharide binding//scavenger receptor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.15005 BP_3 4.00 0.65 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15009 BP_3 307.89 4.22 3811 -- -- -- -- -- 642918185 XM_008193179.1 85 9.69956e-34 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1501 BP_3 9.00 0.35 1534 -- -- -- -- -- 768311752 CP010980.1 1522 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15011 BP_3 4.58 0.56 688 91083589 XP_968607.1 463 9.2e-44 PREDICTED: probable 28S ribosomal protein S25, mitochondrial [Tribolium castaneum]>gi|270006843|gb|EFA03291.1| hypothetical protein TcasGA2_TC013231 [Tribolium castaneum] -- -- -- -- -- K17404 MRPS25 small subunit ribosomal protein S25 http://www.genome.jp/dbget-bin/www_bget?ko:K17404 Q9VY28 412 3.1e-39 Probable 28S ribosomal protein S25, mitochondrial OS=Drosophila melanogaster GN=mRpS25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4079 Putative mitochondrial ribosomal protein mRpS25 Cluster-8309.15012 BP_3 94.42 12.99 642 332376659 AEE63469.1 653 8.0e-66 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17404 MRPS25 small subunit ribosomal protein S25 http://www.genome.jp/dbget-bin/www_bget?ko:K17404 Q9VY28 585 2.5e-59 Probable 28S ribosomal protein S25, mitochondrial OS=Drosophila melanogaster GN=mRpS25 PE=1 SV=1 PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- KOG4079 Putative mitochondrial ribosomal protein mRpS25 Cluster-8309.15013 BP_3 10.00 0.76 929 795014124 XP_011883774.1 144 1.2e-06 PREDICTED: uncharacterized protein LOC105570932 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15014 BP_3 543.00 24.05 1380 189236435 XP_001814418.1 186 2.4e-11 PREDICTED: uncharacterized protein LOC100142298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02234 Cyclin-dependent kinase inhibitor GO:0045859//GO:0007050 regulation of protein kinase activity//cell cycle arrest GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634 nucleus -- -- Cluster-8309.15015 BP_3 363.97 21.18 1120 91079734 XP_970112.1 1146 9.4e-123 PREDICTED: eukaryotic translation initiation factor 6 [Tribolium castaneum]>gi|270003327|gb|EEZ99774.1| hypothetical protein TcasGA2_TC002553 [Tribolium castaneum] -- -- -- -- -- K03264 EIF6 translation initiation factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03264 Q6GR45 1040 7.6e-112 Eukaryotic translation initiation factor 6 OS=Xenopus laevis GN=eif6 PE=2 SV=1 PF01912 eIF-6 family GO:0006413//GO:0042273//GO:0006446//GO:0042256 translational initiation//ribosomal large subunit biogenesis//regulation of translational initiation//mature ribosome assembly GO:0043023//GO:0003743//GO:0043022 ribosomal large subunit binding//translation initiation factor activity//ribosome binding GO:0005737//GO:0005730//GO:0005840 cytoplasm//nucleolus//ribosome KOG3185 Translation initiation factor 6 (eIF-6) Cluster-8309.15016 BP_3 9.03 0.34 1582 805823463 XP_012151697.1 1077 1.3e-114 PREDICTED: eukaryotic translation initiation factor 6 isoform X1 [Megachile rotundata] -- -- -- -- -- K03264 EIF6 translation initiation factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03264 Q6GR45 1033 7.0e-111 Eukaryotic translation initiation factor 6 OS=Xenopus laevis GN=eif6 PE=2 SV=1 PF01912 eIF-6 family GO:0042256 mature ribosome assembly GO:0043022 ribosome binding -- -- KOG3185 Translation initiation factor 6 (eIF-6) Cluster-8309.15018 BP_3 2.60 0.41 596 751440503 XP_011190015.1 432 3.1e-40 PREDICTED: failed axon connections isoform X2 [Bactrocera cucurbitae] 262401476 FJ774922.1 57 5.30833e-19 Scylla paramamosain failed axon connections protein mRNA, partial cds -- -- -- -- Q95RI5 421 2.4e-40 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF06459//PF02535//PF04081//PF02724//PF13417//PF04194//PF08496//PF02798 Ryanodine Receptor TM 4-6//ZIP Zinc transporter//DNA polymerase delta, subunit 4//CDC45-like protein//Glutathione S-transferase, N-terminal domain//Programmed cell death protein 2, C-terminal putative domain//Peptidase family S49 N-terminal//Glutathione S-transferase, N-terminal domain GO:0030001//GO:0006816//GO:0055085//GO:0006270//GO:0006260//GO:0006874 metal ion transport//calcium ion transport//transmembrane transport//DNA replication initiation//DNA replication//cellular calcium ion homeostasis GO:0005515//GO:0005219//GO:0046873//GO:0004252 protein binding//ryanodine-sensitive calcium-release channel activity//metal ion transmembrane transporter activity//serine-type endopeptidase activity GO:0005634//GO:0005886//GO:0016020//GO:0016021//GO:0005622//GO:0005737 nucleus//plasma membrane//membrane//integral component of membrane//intracellular//cytoplasm -- -- Cluster-8309.15019 BP_3 3.00 0.58 543 646714568 KDR18481.1 545 2.2e-53 hypothetical protein L798_07670, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q95RI5 467 1.0e-45 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15020 BP_3 70.62 2.28 1783 478249775 ENN70283.1 1118 2.7e-119 hypothetical protein YQE_13066, partial [Dendroctonus ponderosae] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8NBN7 745 2.0e-77 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- -- -- Cluster-8309.15022 BP_3 129.07 4.40 1707 546678624 ERL89206.1 602 1.7e-59 hypothetical protein D910_06580 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15028 BP_3 1126.70 34.24 1878 225543488 NP_001139390.1 854 1.1e-88 phospholipase A2B precursor [Tribolium castaneum]>gi|224383699|gb|ACN42748.1| phospholipase A2B [Tribolium castaneum]>gi|270011520|gb|EFA07968.1| hypothetical protein TcasGA2_TC005550 [Tribolium castaneum] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P16354 239 9.7e-19 Phospholipase A2 isozymes PA3A/PA3B/PA5 OS=Heloderma suspectum PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15031 BP_3 102.75 3.64 1653 225543488 NP_001139390.1 647 1.0e-64 phospholipase A2B precursor [Tribolium castaneum]>gi|224383699|gb|ACN42748.1| phospholipase A2B [Tribolium castaneum]>gi|270011520|gb|EFA07968.1| hypothetical protein TcasGA2_TC005550 [Tribolium castaneum] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P16354 239 8.5e-19 Phospholipase A2 isozymes PA3A/PA3B/PA5 OS=Heloderma suspectum PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15032 BP_3 16.00 3.22 531 746834577 XP_011067946.1 387 4.6e-35 PREDICTED: uncharacterized protein LOC105154263 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q9NBX5 148 9.7e-09 Nucleic-acid-binding protein from transposon X-element OS=Drosophila melanogaster GN=ORF1 PE=3 SV=1 PF02005 N2,N2-dimethylguanosine tRNA methyltransferase GO:0009451//GO:0008033 RNA modification//tRNA processing GO:0003723//GO:0004809 RNA binding//tRNA (guanine-N2-)-methyltransferase activity -- -- -- -- Cluster-8309.15035 BP_3 81.00 1.96 2281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15038 BP_3 12.16 1.38 716 167444204 ABZ80663.1 352 7.1e-31 hypothetical antimicrobial peptide [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.1504 BP_3 7.00 0.47 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15049 BP_3 17.00 0.37 2505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1505 BP_3 129.39 4.54 1666 270001961 EEZ98408.1 1398 8.5e-152 hypothetical protein TcasGA2_TC000876 [Tribolium castaneum] -- -- -- -- -- K00486 KMO kynurenine 3-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00486 Q7Q6A7 1261 2.7e-137 Kynurenine 3-monooxygenase OS=Anopheles gambiae GN=kh PE=3 SV=2 PF01266//PF01134//PF02558//PF00070//PF03721//PF01494//PF07992//PF02737//PF12831//PF08491 FAD dependent oxidoreductase//Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//Pyridine nucleotide-disulphide oxidoreductase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//FAD dependent oxidoreductase//Squalene epoxidase GO:0016114//GO:0015940//GO:0006550//GO:0006574//GO:0008033//GO:0006554//GO:0006694//GO:0055114//GO:0006568//GO:0006633//GO:0018874//GO:0006552//GO:0006631 terpenoid biosynthetic process//pantothenate biosynthetic process//isoleucine catabolic process//valine catabolic process//tRNA processing//lysine catabolic process//steroid biosynthetic process//oxidation-reduction process//tryptophan metabolic process//fatty acid biosynthetic process//benzoate metabolic process//leucine catabolic process//fatty acid metabolic process GO:0016616//GO:0071949//GO:0004506//GO:0003857//GO:0016491//GO:0051287//GO:0050660//GO:0008677 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//FAD binding//squalene monooxygenase activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//NAD binding//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity GO:0016021 integral component of membrane KOG2614 Kynurenine 3-monooxygenase and related flavoprotein monooxygenases Cluster-8309.15050 BP_3 2.00 1.61 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15055 BP_3 99.73 1.19 4315 189234308 XP_971839.2 2048 9.3e-227 PREDICTED: solute carrier family 35 member F3 [Tribolium castaneum] -- -- -- -- -- K15288 SLC35F3_4 solute carrier family 35, member F3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15288 Q1LZI2 549 2.5e-54 Putative thiamine transporter SLC35F3 OS=Mus musculus GN=Slc35f3 PE=2 SV=1 PF00892//PF06027 EamA-like transporter family//Solute carrier family 35 GO:0006810 transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4314 Predicted carbohydrate/phosphate translocator Cluster-8309.15058 BP_3 153.03 7.16 1322 91084177 XP_966649.1 1219 3.8e-131 PREDICTED: GPN-loop GTPase 1 [Tribolium castaneum]>gi|270008775|gb|EFA05223.1| hypothetical protein TcasGA2_TC015364 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9HCN4 889 2.9e-94 GPN-loop GTPase 1 OS=Homo sapiens GN=GPN1 PE=1 SV=1 PF01926//PF01443//PF08477//PF00025//PF02421//PF06414//PF01637//PF03193//PF10662//PF00071//PF00931 50S ribosome-binding GTPase//Viral (Superfamily 1) RNA helicase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B//Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//Ethanolamine utilisation - propanediol utilisation//Ras family//NB-ARC domain GO:0006576//GO:0007264//GO:0015684 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005524//GO:0015093//GO:0043531//GO:0003924//GO:0000166//GO:0005525//GO:0016301 ATP binding//ferrous iron transmembrane transporter activity//ADP binding//GTPase activity//nucleotide binding//GTP binding//kinase activity GO:0016021 integral component of membrane KOG1532 GTPase XAB1, interacts with DNA repair protein XPA Cluster-8309.15060 BP_3 27.74 0.71 2188 642915726 XP_008190777.1 1152 3.7e-123 PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum]>gi|642915728|ref|XP_008190778.1| PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NWF9 288 2.4e-24 E3 ubiquitin-protein ligase RNF216 OS=Homo sapiens GN=RNF216 PE=1 SV=3 PF03119//PF10044//PF02807 NAD-dependent DNA ligase C4 zinc finger domain//Retinal tissue protein//ATP:guanido phosphotransferase, N-terminal domain GO:0006281//GO:0006351//GO:0007049//GO:0006260 DNA repair//transcription, DNA-templated//cell cycle//DNA replication GO:0003911//GO:0016301//GO:0016772 DNA ligase (NAD+) activity//kinase activity//transferase activity, transferring phosphorus-containing groups GO:0070176 DRM complex -- -- Cluster-8309.15061 BP_3 41.50 0.66 3306 478256643 ENN76825.1 646 2.7e-64 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAM1 415 6.7e-39 Alpha-taxilin OS=Mus musculus GN=Txlna PE=2 SV=1 PF05531//PF09728//PF05336 Nucleopolyhedrovirus P10 protein//Myosin-like coiled-coil protein//Domain of unknown function (DUF718) GO:0019299 rhamnose metabolic process GO:0019905//GO:0016857 syntaxin binding//racemase and epimerase activity, acting on carbohydrates and derivatives GO:0005737//GO:0019028 cytoplasm//viral capsid KOG1850 Myosin-like coiled-coil protein Cluster-8309.15062 BP_3 398.00 6.21 3382 642929376 XP_008195810.1 1360 4.4e-147 PREDICTED: condensin complex subunit 3-like [Tribolium castaneum]>gi|270010519|gb|EFA06967.1| hypothetical protein TcasGA2_TC009926 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YHB5 689 1.2e-70 Condensin complex subunit 3 OS=Xenopus laevis GN=ncapg PE=1 SV=1 PF02985//PF02151//PF16048//PF00514 HEAT repeat//UvrB/uvrC motif//Frog antimicrobial peptide//Armadillo/beta-catenin-like repeat GO:0006952 defense response GO:0005515 protein binding GO:0005576 extracellular region KOG2025 Chromosome condensation complex Condensin, subunit G Cluster-8309.15063 BP_3 11.00 0.45 1474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15064 BP_3 11.00 0.55 1264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15065 BP_3 81.00 0.97 4314 478255001 ENN75234.1 2758 4.4e-309 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P91660 1080 6.7e-116 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00437//PF00004//PF01443//PF00664//PF01926//PF00158//PF13304//PF00931//PF02565//PF01637//PF02367//PF06414//PF00005//PF03193 Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Viral (Superfamily 1) RNA helicase//ABC transporter transmembrane region//50S ribosome-binding GTPase//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//NB-ARC domain//Recombination protein O C terminal//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006310//GO:0002949//GO:0006355//GO:0006281//GO:0006810//GO:0055085 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair//transport//transmembrane transport GO:0005525//GO:0043531//GO:0042626//GO:0016887//GO:0016301//GO:0008134//GO:0003924//GO:0005524 GTP binding//ADP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//transcription factor binding//GTPase activity//ATP binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-8309.15067 BP_3 17.49 0.31 2990 478258919 ENN78899.1 915 1.5e-95 hypothetical protein YQE_04637, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O02640 361 1.1e-32 Probable malate dehydrogenase, mitochondrial OS=Caenorhabditis elegans GN=mdh-2 PE=3 SV=1 PF00056//PF02866 lactate/malate dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0016616 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-8309.15073 BP_3 89.89 1.01 4595 642922752 XP_008193309.1 474 3.2e-44 PREDICTED: uncharacterized protein LOC103312998 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00003//PF02979//PF00514//PF02600//PF00552 7 transmembrane sweet-taste receptor of 3 GCPR//Nitrile hydratase, alpha chain//Armadillo/beta-catenin-like repeat//Disulfide bond formation protein DsbB//Integrase DNA binding domain GO:0006807//GO:0007186//GO:0006118 nitrogen compound metabolic process//G-protein coupled receptor signaling pathway//obsolete electron transport GO:0015035//GO:0003676//GO:0005515//GO:0004930//GO:0046914//GO:0003824 protein disulfide oxidoreductase activity//nucleic acid binding//protein binding//G-protein coupled receptor activity//transition metal ion binding//catalytic activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.15074 BP_3 108.95 4.09 1577 478255900 ENN76104.1 913 1.4e-95 hypothetical protein YQE_07364, partial [Dendroctonus ponderosae] -- -- -- -- -- K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 Q75WV3 294 3.4e-25 Probable trehalose-phosphate phosphatase 1 OS=Oryza sativa subsp. japonica GN=TPP1 PE=1 SV=1 PF02358//PF03310 Trehalose-phosphatase//Caulimovirus DNA-binding protein GO:0005992 trehalose biosynthetic process GO:0003677//GO:0003824 DNA binding//catalytic activity -- -- -- -- Cluster-8309.15075 BP_3 8.05 0.32 1518 478255900 ENN76104.1 913 1.3e-95 hypothetical protein YQE_07364, partial [Dendroctonus ponderosae] -- -- -- -- -- K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 Q75WV3 294 3.3e-25 Probable trehalose-phosphate phosphatase 1 OS=Oryza sativa subsp. japonica GN=TPP1 PE=1 SV=1 PF03310//PF02358 Caulimovirus DNA-binding protein//Trehalose-phosphatase GO:0005992 trehalose biosynthetic process GO:0003824//GO:0003677 catalytic activity//DNA binding -- -- -- -- Cluster-8309.15079 BP_3 64.61 2.12 1762 817088843 XP_012267256.1 438 1.9e-40 PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae]>gi|817088845|ref|XP_012267257.1| PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae] -- -- -- -- -- K03004 RPA43 DNA-directed RNA polymerase I subunit RPA43 http://www.genome.jp/dbget-bin/www_bget?ko:K03004 Q3B726 275 6.1e-23 DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens GN=TWISTNB PE=1 SV=1 PF03876 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG4134 DNA-dependent RNA polymerase I Cluster-8309.1508 BP_3 39.17 2.48 1052 270010676 EFA07124.1 429 1.2e-39 hypothetical protein TcasGA2_TC010115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N6V9 222 5.1e-17 Testis-expressed sequence 9 protein OS=Homo sapiens GN=TEX9 PE=2 SV=1 PF01743//PF10473//PF07926//PF00769//PF04111//PF04977//PF10186//PF13851 Poly A polymerase head domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//Ezrin/radixin/moesin family//Autophagy protein Apg6//Septum formation initiator//Vacuolar sorting 38 and autophagy-related subunit 14//Growth-arrest specific micro-tubule binding GO:0006914//GO:0006606//GO:0006396//GO:0007049//GO:0010508//GO:0048870 autophagy//protein import into nucleus//RNA processing//cell cycle//positive regulation of autophagy//cell motility GO:0008134//GO:0045502//GO:0016779//GO:0008092//GO:0003723//GO:0042803 transcription factor binding//dynein binding//nucleotidyltransferase activity//cytoskeletal protein binding//RNA binding//protein homodimerization activity GO:0031514//GO:0019898//GO:0005737//GO:0030286//GO:0005667 motile cilium//extrinsic component of membrane//cytoplasm//dynein complex//transcription factor complex -- -- Cluster-8309.15080 BP_3 22.00 4.24 542 113951691 NP_001039280.1 410 1.0e-37 chemosensory protein 12 precursor [Tribolium castaneum]>gi|112031836|gb|ABH88185.1| chemosensory protein 12 [Tribolium castaneum]>gi|270010974|gb|EFA07422.1| chemosensory protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W1C9 321 8.7e-29 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15082 BP_3 94.00 2.27 2287 189241122 XP_001812931.1 721 3.7e-73 PREDICTED: protein saal1 [Tribolium castaneum]>gi|270013331|gb|EFA09779.1| hypothetical protein TcasGA2_TC011921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q803M5 199 5.1e-14 Protein saal1 OS=Danio rerio GN=saal1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15084 BP_3 81.92 1.81 2470 642924858 XP_008194069.1 1120 2.2e-119 PREDICTED: uncharacterized protein LOC103313199 [Tribolium castaneum]>gi|270006682|gb|EFA03130.1| hypothetical protein TcasGA2_TC013041 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04333//PF00168 MlaA lipoprotein//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.15087 BP_3 2.60 0.88 434 646719707 KDR21725.1 488 7.3e-47 putative E3 ubiquitin-protein ligase MYCBP2, partial [Zootermopsis nevadensis] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 Q7TPH6 394 2.4e-37 E3 ubiquitin-protein ligase MYCBP2 OS=Mus musculus GN=Mycbp2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15089 BP_3 8.00 1.06 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1509 BP_3 20.17 1.01 1254 270010676 EFA07124.1 375 2.7e-33 hypothetical protein TcasGA2_TC010115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10473//PF01743//PF04977//PF04111//PF07851//PF09728 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Poly A polymerase head domain//Septum formation initiator//Autophagy protein Apg6//TMPIT-like protein//Myosin-like coiled-coil protein GO:0006396//GO:0007049//GO:0006914 RNA processing//cell cycle//autophagy GO:0016779//GO:0042803//GO:0008134//GO:0045502//GO:0019905//GO:0003723 nucleotidyltransferase activity//protein homodimerization activity//transcription factor binding//dynein binding//syntaxin binding//RNA binding GO:0005667//GO:0030286//GO:0016021 transcription factor complex//dynein complex//integral component of membrane -- -- Cluster-8309.15094 BP_3 20.50 1.01 1274 755875739 XP_011292600.1 155 8.8e-08 PREDICTED: longitudinals lacking protein, isoforms H/M/V-like isoform X4 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05495//PF00096 CHY zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.15097 BP_3 22.47 0.50 2438 731463707 XP_003407411.2 648 1.1e-64 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100675838 [Loxodonta africana] 642923856 XM_008195686.1 201 2.02619e-98 PREDICTED: Tribolium castaneum uncharacterized LOC663851 (LOC663851), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 603 7.8e-61 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF13465//PF07975//PF13912//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.15098 BP_3 65.58 1.21 2912 91088445 XP_968690.1 1260 1.5e-135 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 857 3.3e-90 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF00515//PF07497//PF13371//PF13176//PF04658//PF00520//PF13414//PF13181//PF04564//PF02465 Tetratricopeptide repeat//Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//TAFII55 protein conserved region//Ion transport protein//TPR repeat//Tetratricopeptide repeat//U-box domain//Flagellar hook-associated protein 2 N-terminus GO:0016567//GO:0055085//GO:0006367//GO:0006811//GO:0006353 protein ubiquitination//transmembrane transport//transcription initiation from RNA polymerase II promoter//ion transport//DNA-templated transcription, termination GO:0004842//GO:0005515//GO:0003723//GO:0005216 ubiquitin-protein transferase activity//protein binding//RNA binding//ion channel activity GO:0000151//GO:0005669//GO:0009424//GO:0016020 ubiquitin ligase complex//transcription factor TFIID complex//bacterial-type flagellum hook//membrane KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.15100 BP_3 62.00 3.95 1049 -- -- -- -- -- 697072656 XM_009652837.1 579 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- Q01589 166 1.6e-10 Cell wall protein SED1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SED1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15102 BP_3 11.00 1.59 626 -- -- -- -- -- 697070692 XM_009652134.1 606 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15103 BP_3 29.00 0.96 1752 -- -- -- -- -- 768311753 CP010981.1 1261 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF14987//PF13371 NADH dehydrogenase 1 alpha subcomplex subunit 3//Tetratricopeptide repeat -- -- GO:0005515 protein binding GO:0005747//GO:0005743 mitochondrial respiratory chain complex I//mitochondrial inner membrane -- -- Cluster-8309.15104 BP_3 30.00 3.10 758 -- -- -- -- -- 697069574 XM_009651676.1 648 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15106 BP_3 3.00 2.34 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12899 Alkaline and neutral invertase -- -- GO:0033926 glycopeptide alpha-N-acetylgalactosaminidase activity -- -- -- -- Cluster-8309.15108 BP_3 273.50 11.10 1479 282720985 NP_001164243.1 428 2.3e-39 angiotensin-converting enzyme 3 precursor [Tribolium castaneum]>gi|270015941|gb|EFA12389.1| Ance-3 [Tribolium castaneum] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q9VLJ6 262 1.6e-21 Angiotensin-converting enzyme-related protein OS=Drosophila melanogaster GN=Acer PE=1 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane -- -- Cluster-8309.15111 BP_3 19.00 13.87 353 826469534 XP_012535839.1 424 1.6e-39 PREDICTED: uncharacterized protein LOC105836387 [Monomorium pharaonis] 826469533 XM_012680385.1 133 1.70742e-61 PREDICTED: Monomorium pharaonis uncharacterized LOC105836387 (LOC105836387), mRNA -- -- -- -- -- -- -- -- PF12558 ATP-binding cassette cobalt transporter -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- -- -- Cluster-8309.15112 BP_3 197.26 10.02 1241 817080904 XP_012262936.1 403 1.5e-36 PREDICTED: uncharacterized protein LOC105690035 [Athalia rosae] 751199911 XM_011161007.1 106 6.56875e-46 PREDICTED: Solenopsis invicta uncharacterized LOC105195552 (LOC105195552), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15114 BP_3 46.61 2.62 1148 817080904 XP_012262936.1 232 9.3e-17 PREDICTED: uncharacterized protein LOC105690035 [Athalia rosae] 751199911 XM_011161007.1 75 1.03744e-28 PREDICTED: Solenopsis invicta uncharacterized LOC105195552 (LOC105195552), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15115 BP_3 5.00 0.84 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15118 BP_3 47.46 3.46 953 91076370 XP_967715.1 1040 1.6e-110 PREDICTED: ras-related protein Rab-27A [Tribolium castaneum]>gi|270002552|gb|EEZ98999.1| hypothetical protein TcasGA2_TC004860 [Tribolium castaneum] 752877090 XR_889181.1 40 2.44785e-09 PREDICTED: Camponotus floridanus ras-related protein Rab-8A (LOC105251123), transcript variant X2, misc_RNA K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 Q4LE85 742 2.3e-77 Ras-related protein Rab-27A OS=Sus scrofa GN=RAB27A PE=2 SV=1 PF00025//PF00071//PF08477//PF03193//PF01926 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0093 GTPase Rab3, small G protein superfamily Cluster-8309.15119 BP_3 61.00 3.16 1222 258645094 NP_001158260.1 1001 6.7e-106 grain [Tribolium castaneum] 258645093 NM_001164788.1 348 1.921e-180 Tribolium castaneum grain (Grn), mRNA K17895 GATA3 GATA-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17895 Q91428 223 4.5e-17 Transcription factor GATA-3 OS=Danio rerio GN=gata3 PE=2 SV=1 PF00297//PF08273//PF00320 Ribosomal protein L3//Zinc-binding domain of primase-helicase//GATA zinc finger GO:0042254//GO:0006269//GO:0006355//GO:0006412//GO:0006351 ribosome biogenesis//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//translation//transcription, DNA-templated GO:0003896//GO:0003700//GO:0043565//GO:0003735//GO:0008270//GO:0004386 DNA primase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//structural constituent of ribosome//zinc ion binding//helicase activity GO:0005730//GO:0005622//GO:0005840//GO:0005667//GO:0005657 nucleolus//intracellular//ribosome//transcription factor complex//replication fork KOG1601 GATA-4/5/6 transcription factors Cluster-8309.1512 BP_3 19.00 1.04 1169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15120 BP_3 104.00 2.83 2061 768438692 XP_011560942.1 429 2.4e-39 PREDICTED: GATA-binding factor C-like isoform X2 [Plutella xylostella] 241998887 XM_002434042.1 139 4.99087e-64 Ixodes scapularis endothelial transcription factor GATA-2, putative, mRNA K17894 GATA2 GATA-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17894 P91623 404 7.8e-38 GATA-binding factor C OS=Drosophila melanogaster GN=grn PE=2 SV=1 PF00320//PF01873 GATA zinc finger//Domain found in IF2B/IF5 GO:0006446//GO:0006355//GO:0006413 regulation of translational initiation//regulation of transcription, DNA-templated//translational initiation GO:0003743//GO:0003700//GO:0008270//GO:0043565 translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005840 transcription factor complex//ribosome KOG1601 GATA-4/5/6 transcription factors Cluster-8309.15121 BP_3 9.91 0.45 1346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15124 BP_3 2.00 7.40 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15126 BP_3 156.32 3.31 2569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15128 BP_3 356.83 20.30 1139 91087501 XP_968536.1 586 8.3e-58 PREDICTED: DNA replication complex GINS protein PSF3 [Tribolium castaneum]>gi|270010665|gb|EFA07113.1| hypothetical protein TcasGA2_TC010104 [Tribolium castaneum] -- -- -- -- -- K10734 GINS3 GINS complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10734 Q5RDV0 241 3.4e-19 DNA replication complex GINS protein PSF3 OS=Pongo abelii GN=GINS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15129 BP_3 25.00 10.10 410 755935571 XP_011315369.1 276 2.6e-22 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Fopius arisanus] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q922J9 178 2.5e-12 Fatty acyl-CoA reductase 1 OS=Mus musculus GN=Far1 PE=1 SV=1 PF01118 Semialdehyde dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016620//GO:0051287 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.15130 BP_3 49.00 2.02 1460 123227460 CAM27169.1 247 2.2e-18 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] -- -- -- -- -- K09210 KLF15 krueppel-like factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09210 Q5VIY5 241 4.4e-19 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.15135 BP_3 5.00 0.65 661 -- -- -- -- -- 642936890 XR_511484.1 53 9.91008e-17 PREDICTED: Tribolium castaneum tropomodulin (LOC658846), transcript variant X2, misc_RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15136 BP_3 3.35 0.39 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15137 BP_3 30.00 0.41 3784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15140 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15145 BP_3 139.00 2.73 2742 546685658 ERL95124.1 1069 2.0e-113 hypothetical protein D910_12394, partial [Dendroctonus ponderosae] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 A0FI79 422 8.5e-40 72 kDa inositol polyphosphate 5-phosphatase OS=Pan troglodytes GN=INPP5E PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.15147 BP_3 16.01 0.47 1950 91083015 XP_974607.1 216 1.1e-14 PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|642923430|ref|XP_008193741.1| PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|270007020|gb|EFA03468.1| hypothetical protein TcasGA2_TC013464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07730 Histidine kinase GO:0000160//GO:0016310 phosphorelay signal transduction system//phosphorylation GO:0000155//GO:0046983 phosphorelay sensor kinase activity//protein dimerization activity GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex -- -- Cluster-8309.1515 BP_3 46.50 0.78 3165 805806704 XP_012146119.1 259 1.9e-19 PREDICTED: uncharacterized protein LOC105663206 isoform X2 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01527//PF01312//PF06524//PF16866//PF07649//PF00628//PF14634//PF05225//PF00130//PF04705 Transposase//FlhB HrpN YscU SpaS Family//NOA36 protein//PHD-finger//C1-like domain//PHD-finger//zinc-RING finger domain//helix-turn-helix, Psq domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Thiostrepton-resistance methylase, N terminus GO:0046677//GO:0000154//GO:0055114//GO:0035556//GO:0006396//GO:0009306//GO:0006313 response to antibiotic//rRNA modification//oxidation-reduction process//intracellular signal transduction//RNA processing//protein secretion//transposition, DNA-mediated GO:0008270//GO:0047134//GO:0004803//GO:0003677//GO:0005515//GO:0008649 zinc ion binding//protein-disulfide reductase activity//transposase activity//DNA binding//protein binding//rRNA methyltransferase activity GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.15151 BP_3 151.81 3.76 2237 91094333 XP_969230.1 955 2.7e-100 PREDICTED: acyl-protein thioesterase 1 [Tribolium castaneum] -- -- -- -- -- K06130 LYPLA2 lysophospholipase II http://www.genome.jp/dbget-bin/www_bget?ko:K06130 Q5RBR7 628 9.0e-64 Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1 PF01764//PF00326//PF05577//PF02230//PF10503//PF07859//PF01738 Lipase (class 3)//Prolyl oligopeptidase family//Serine carboxypeptidase S28//Phospholipase/Carboxylesterase//Esterase PHB depolymerase//alpha/beta hydrolase fold//Dienelactone hydrolase family GO:0006629//GO:0006508//GO:0008152 lipid metabolic process//proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity GO:0005576 extracellular region KOG2112 Lysophospholipase Cluster-8309.15155 BP_3 1.00 9.71 244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15157 BP_3 11.85 0.67 1146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1516 BP_3 40.64 1.44 1652 546676649 ERL87613.1 434 5.1e-40 hypothetical protein D910_05004 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15160 BP_3 77.00 6.12 898 332168659 AEE25770.1 1388 6.6e-151 chymotrypsin [Scylla paramamosain] 332168658 JF831535.1 895 0 Scylla paramamosain chymotrypsin mRNA, complete cds K01311 CTRC chymotrypsin C http://www.genome.jp/dbget-bin/www_bget?ko:K01311 Q00871 1149 1.4e-124 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.15161 BP_3 23.49 0.91 1541 91081129 XP_975539.1 584 1.9e-57 PREDICTED: GILT-like protein F37H8.5 [Tribolium castaneum]>gi|270005287|gb|EFA01735.1| hypothetical protein TcasGA2_TC007331 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O17861 192 2.2e-13 GILT-like protein F37H8.5 OS=Caenorhabditis elegans GN=F37H8.5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.15163 BP_3 3.00 0.49 585 91092412 XP_967539.1 297 1.4e-24 PREDICTED: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [Tribolium castaneum]>gi|270004747|gb|EFA01195.1| hypothetical protein TcasGA2_TC010522 [Tribolium castaneum] -- -- -- -- -- K05542 DUS1 tRNA-dihydrouridine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05542 -- -- -- -- PF07355 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) GO:0002943//GO:0055114 tRNA dihydrouridine synthesis//oxidation-reduction process GO:0050660//GO:0017150//GO:0050485 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity//oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor -- -- -- -- Cluster-8309.15175 BP_3 65.64 0.46 7169 642919044 XP_008191710.1 2033 8.5e-225 PREDICTED: neurotactin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23654 1323 7.4e-144 Neurotactin OS=Drosophila melanogaster GN=Nrt PE=1 SV=3 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.15177 BP_3 5.00 0.50 777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15179 BP_3 185.54 1.89 5032 91086891 XP_970454.1 569 3.4e-55 PREDICTED: putative gamma-glutamylcyclotransferase CG2811 isoform X1 [Tribolium castaneum]>gi|270010478|gb|EFA06926.1| hypothetical protein TcasGA2_TC009875 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y2 357 5.4e-32 Putative gamma-glutamylcyclotransferase CG2811 OS=Drosophila melanogaster GN=CG2811 PE=2 SV=2 PF13903//PF07062 PMP-22/EMP/MP20/Claudin tight junction//Clc-like -- -- -- -- GO:0016021 integral component of membrane KOG4450 Uncharacterized conserved protein Cluster-8309.15184 BP_3 1.31 0.59 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1519 BP_3 9.00 1.03 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15190 BP_3 201.78 9.84 1280 642924004 XP_008193965.1 1014 2.2e-107 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 376 8.6e-35 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF03275//PF00400 UDP-galactopyranose mutase//WD domain, G-beta repeat -- -- GO:0008767//GO:0005515 UDP-galactopyranose mutase activity//protein binding -- -- KOG1188 WD40 repeat protein Cluster-8309.15191 BP_3 8.80 0.44 1246 332372885 AEE61584.1 492 7.2e-47 unknown [Dendroctonus ponderosae]>gi|478252324|gb|ENN72750.1| hypothetical protein YQE_10555, partial [Dendroctonus ponderosae]>gi|546680657|gb|ERL90883.1| hypothetical protein D910_08228 [Dendroctonus ponderosae] 820856991 XR_001112512.1 69 2.44043e-25 PREDICTED: Apis florea uncharacterized protein C1orf43 homolog (LOC100869278), transcript variant X3, misc_RNA -- -- -- -- Q9BWL3 193 1.4e-13 Uncharacterized protein C1orf43 OS=Homo sapiens GN=C1orf43 PE=2 SV=1 PF00998 Viral RNA dependent RNA polymerase GO:0039694//GO:0006144 viral RNA genome replication//purine nucleobase metabolic process GO:0003723//GO:0003968 RNA binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.15192 BP_3 45.15 2.69 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15193 BP_3 18.00 0.50 2035 749797390 XP_011152150.1 1234 1.1e-132 PREDICTED: MFS-type transporter SLC18B1-like [Harpegnathos saltator]>gi|307193153|gb|EFN76059.1| Uncharacterized MFS-type transporter C6orf192 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- D3Z5L6 649 3.0e-66 MFS-type transporter SLC18B1 OS=Mus musculus GN=Slc18b1 PE=2 SV=2 PF03092//PF07690 BT1 family//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.15195 BP_3 66.00 1.37 2611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15197 BP_3 2.00 2.91 311 861595638 KMQ83178.1 163 2.5e-09 hypothetical protein RF55_20704 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1520 BP_3 12.00 0.33 2068 270005125 EFA01573.1 220 4.1e-15 hypothetical protein TcasGA2_TC007134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04159 NB glycoprotein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.15202 BP_3 5.01 0.33 1029 546678480 ERL89088.1 367 1.9e-32 hypothetical protein D910_06465, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04546 Sigma-70, non-essential region GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0003700 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.15205 BP_3 234.68 7.45 1810 332376975 AEE63627.1 1501 1.0e-163 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 141 3.38019e-65 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1367 1.5e-149 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF02984//PF01857//PF00382//PF04545 Cyclin, C-terminal domain//Retinoblastoma-associated protein B domain//Transcription factor TFIIB repeat//Sigma-70, region 4 GO:0051726//GO:0006355//GO:0006352 regulation of cell cycle//regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0003700//GO:0017025 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding//TBP-class protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1597 Transcription initiation factor TFIIB Cluster-8309.15207 BP_3 107.67 1.07 5129 642929943 XP_008196036.1 680 4.7e-68 PREDICTED: microtubule-associated protein futsch-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q767L8 268 1.2e-21 Mediator of DNA damage checkpoint protein 1 OS=Sus scrofa GN=MDC1 PE=3 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.15208 BP_3 4.07 1.00 487 478254758 ENN74995.1 310 3.6e-26 hypothetical protein YQE_08452, partial [Dendroctonus ponderosae] -- -- -- -- -- K03950 NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03950 Q02366 213 2.6e-16 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Bos taurus GN=NDUFA6 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3426 NADH:ubiquinone oxidoreductase, NDUFA6/B14 subunit Cluster-8309.15209 BP_3 89.72 0.58 7770 642914671 XP_008190309.1 727 2.5e-73 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTX9 324 5.6e-28 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF07690//PF05631 Sugar (and other) transporter//Major Facilitator Superfamily//Sugar-tranasporters, 12 TM GO:0055085//GO:0015689 transmembrane transport//molybdate ion transport GO:0022857//GO:0015098 transmembrane transporter activity//molybdate ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.15210 BP_3 81.44 0.40 9997 642914671 XP_008190309.1 831 2.8e-85 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 401 8.5e-37 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF05631//PF07690 Sugar (and other) transporter//Sugar-tranasporters, 12 TM//Major Facilitator Superfamily GO:0015689//GO:0055085 molybdate ion transport//transmembrane transport GO:0015098//GO:0022857 molybdate ion transmembrane transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.15212 BP_3 29.78 0.48 3296 189233840 XP_001809010.1 416 1.2e-37 PREDICTED: nucleolar transcription factor 1-like [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 256 1.8e-20 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15220 BP_3 250.75 3.56 3686 546681046 ERL91211.1 1248 4.6e-134 hypothetical protein D910_08549 [Dendroctonus ponderosae] -- -- -- -- -- K15119 SLC25A39_40 solute carrier family 25, member 39/40 http://www.genome.jp/dbget-bin/www_bget?ko:K15119 Q6DHC3 920 2.1e-97 Solute carrier family 25 member 40 OS=Danio rerio GN=slc25a40 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0761 Mitochondrial carrier protein CGI-69 Cluster-8309.15227 BP_3 4.91 13.38 284 478256535 ENN76719.1 227 8.7e-17 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.1523 BP_3 22.00 15.25 357 478263116 ENN81509.1 159 8.5e-09 hypothetical protein YQE_02038, partial [Dendroctonus ponderosae]>gi|546672296|gb|ERL84223.1| hypothetical protein D910_01601 [Dendroctonus ponderosae]>gi|546675497|gb|ERL86682.1| hypothetical protein D910_04088 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15230 BP_3 4.00 0.33 883 375153528 AFA36654.1 498 1.0e-47 elongation factor 1-delta protein [Eriocheir sinensis] 375153527 JN638238.1 393 0 Eriocheir sinensis elongation factor 1-delta protein mRNA, complete cds K15410 EEF1D elongation factor 1-delta http://www.genome.jp/dbget-bin/www_bget?ko:K15410 P12262 434 1.1e-41 Elongation factor 1-beta OS=Artemia salina PE=1 SV=3 PF00736//PF04513//PF00170 EF-1 guanine nucleotide exchange domain//Baculovirus polyhedron envelope protein, PEP, C terminus//bZIP transcription factor GO:0006355//GO:0006414//GO:0006448 regulation of transcription, DNA-templated//translational elongation//regulation of translational elongation GO:0043565//GO:0003746//GO:0003700//GO:0005198 sequence-specific DNA binding//translation elongation factor activity//transcription factor activity, sequence-specific DNA binding//structural molecule activity GO:0005840//GO:0005853//GO:0019028//GO:0005667//GO:0019031 ribosome//eukaryotic translation elongation factor 1 complex//viral capsid//transcription factor complex//viral envelope KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.15231 BP_3 5.00 0.63 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15235 BP_3 6.00 0.47 904 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15246 BP_3 641.62 18.83 1934 91093659 XP_966349.1 2157 9.6e-240 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] 686775201 LM127048.1 46 2.33602e-12 Taenia asiatica genome assembly T_asiatica_South_Korea ,scaffold TASK_contig0000687 K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 Q9W3K5 1913 7.7e-213 Glutamate--cysteine ligase OS=Drosophila melanogaster GN=Gclc PE=2 SV=1 PF00355//PF03074 Rieske [2Fe-2S] domain//Glutamate-cysteine ligase GO:0055114//GO:0006750//GO:0006749 oxidation-reduction process//glutathione biosynthetic process//glutathione metabolic process GO:0016491//GO:0004357//GO:0051537 oxidoreductase activity//glutamate-cysteine ligase activity//2 iron, 2 sulfur cluster binding GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.15248 BP_3 40.44 0.35 5842 642917577 XP_008191264.1 750 4.1e-76 PREDICTED: zinc transporter ZIP11 isoform X3 [Tribolium castaneum] -- -- -- -- -- K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 P43005 456 2.1e-43 Excitatory amino acid transporter 3 OS=Homo sapiens GN=SLC1A1 PE=1 SV=2 PF00375//PF01903//PF01127//PF02535 Sodium:dicarboxylate symporter family//CbiX//Succinate dehydrogenase/Fumarate reductase transmembrane subunit//ZIP Zinc transporter GO:0006812//GO:0006835//GO:0006783//GO:0009236//GO:0006820//GO:0030001//GO:0055085 cation transport//dicarboxylic acid transport//heme biosynthetic process//cobalamin biosynthetic process//anion transport//metal ion transport//transmembrane transport GO:0046873//GO:0016627//GO:0017153//GO:0016852 metal ion transmembrane transporter activity//oxidoreductase activity, acting on the CH-CH group of donors//sodium:dicarboxylate symporter activity//sirohydrochlorin cobaltochelatase activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.1525 BP_3 16.12 0.49 1873 478252288 ENN72715.1 415 9.2e-38 hypothetical protein YQE_10653, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5DU00 142 1.7e-07 Doublecortin domain-containing protein 2 OS=Mus musculus GN=Dcdc2 PE=2 SV=2 PF03607 Doublecortin GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.15257 BP_3 17.34 1.06 1083 478250083 ENN70589.1 220 2.2e-15 hypothetical protein YQE_12764, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1526 BP_3 10.00 1.20 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15262 BP_3 495.62 10.72 2520 642910817 XP_008193421.1 1463 3.7e-159 PREDICTED: rab11 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 1.0e-26 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15263 BP_3 63.49 1.42 2454 642910823 XP_008193424.1 1393 4.7e-151 PREDICTED: rab11 family-interacting protein 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 9.7e-27 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15264 BP_3 24.49 0.45 2907 189242442 XP_001807060.1 389 1.5e-34 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- K19599 DOME cytokine receptor domeless http://www.genome.jp/dbget-bin/www_bget?ko:K19599 -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15267 BP_3 13.00 1.46 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05502//PF03554 Dynactin p62 family//UL73 viral envelope glycoprotein -- -- -- -- GO:0005869//GO:0019031 dynactin complex//viral envelope -- -- Cluster-8309.1527 BP_3 10.00 0.36 1633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15271 BP_3 2.00 1.02 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15272 BP_3 10.77 0.75 988 91079458 XP_966537.1 486 2.8e-46 PREDICTED: SAP30-binding protein [Tribolium castaneum]>gi|270004398|gb|EFA00846.1| hypothetical protein TcasGA2_TC003747 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UHR5 214 4.0e-16 SAP30-binding protein OS=Homo sapiens GN=SAP30BP PE=1 SV=1 PF07818//PF05558 HCNGP-like protein//DREPP plasma membrane polypeptide GO:0006355//GO:0051716 regulation of transcription, DNA-templated//cellular response to stimulus -- -- GO:0046658 anchored component of plasma membrane -- -- Cluster-8309.15275 BP_3 270.00 4.90 2950 189235344 XP_975427.2 1954 5.0e-216 PREDICTED: transmembrane protein 135-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4F4 587 6.8e-59 Transmembrane protein 135 OS=Rattus norvegicus GN=Tmem135 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1398 Uncharacterized conserved protein Cluster-8309.15281 BP_3 31.12 0.76 2258 646696193 KDR08640.1 667 6.7e-67 hypothetical protein L798_01542 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08655 DASH complex subunit Ask1 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.15283 BP_3 489.19 12.73 2144 642935034 XP_008199914.1 150 5.6e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 198 8.27359e-97 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF10186//PF03938//PF04111//PF05835//PF02841 Vacuolar sorting 38 and autophagy-related subunit 14//Outer membrane protein (OmpH-like)//Autophagy protein Apg6//Synaphin protein//Guanylate-binding protein, C-terminal domain GO:0006836//GO:0006914//GO:0010508 neurotransmitter transport//autophagy//positive regulation of autophagy GO:0005525//GO:0051082//GO:0019905//GO:0003924 GTP binding//unfolded protein binding//syntaxin binding//GTPase activity -- -- -- -- Cluster-8309.15284 BP_3 22.16 0.56 2208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769//PF03603 Divalent cation transporter//DNA polymerase III psi subunit GO:0006812//GO:0006260 cation transport//DNA replication GO:0008324//GO:0008408//GO:0003887 cation transmembrane transporter activity//3'-5' exonuclease activity//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.15287 BP_3 20.62 1.07 1222 642919373 XP_008191844.1 734 6.1e-75 PREDICTED: vascular endothelial growth factor receptor 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P35969 445 8.2e-43 Vascular endothelial growth factor receptor 1 OS=Mus musculus GN=Flt1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.15288 BP_3 13.56 0.58 1420 270005515 EFA01963.1 717 6.7e-73 hypothetical protein TcasGA2_TC007584 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 Q8AXB3 439 4.7e-42 Vascular endothelial growth factor receptor kdr-like OS=Danio rerio GN=kdrl PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.15291 BP_3 77.38 1.44 2875 391335701 XP_003742228.1 618 4.1e-61 PREDICTED: uncharacterized protein LOC100899883 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15295 BP_3 14.06 0.42 1914 270005690 EFA02138.1 363 1.0e-31 hypothetical protein TcasGA2_TC007788 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 209 3.0e-15 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 PF00895//PF02310 ATP synthase protein 8//B12 binding domain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0046872//GO:0031419//GO:0015078 metal ion binding//cobalamin binding//hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2882 p-Nitrophenyl phosphatase Cluster-8309.153 BP_3 19.00 0.78 1473 662188963 XP_008488180.1 1166 6.0e-125 PREDICTED: LOW QUALITY PROTEIN: whirlin-like, partial [Diaphorina citri] 642917475 XM_008192996.1 293 8.73308e-150 PREDICTED: Tribolium castaneum whirlin-like (LOC655925), transcript variant X2, mRNA -- -- -- -- Q9P202 552 3.9e-55 Whirlin OS=Homo sapiens GN=DFNB31 PE=1 SV=3 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.1530 BP_3 9.00 0.94 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15306 BP_3 116.47 3.78 1775 91088521 XP_971980.1 407 7.4e-37 PREDICTED: protein drumstick isoform X2 [Tribolium castaneum]>gi|270012231|gb|EFA08679.1| hypothetical protein TcasGA2_TC006347 [Tribolium castaneum] -- -- -- -- -- K09215 OSR, ODD odd-skipped http://www.genome.jp/dbget-bin/www_bget?ko:K09215 Q7PN68 392 1.7e-36 Protein drumstick OS=Anopheles gambiae GN=drm PE=3 SV=1 PF13465//PF00096//PF01155//PF13912//PF00643//PF02892//PF00412 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//C2H2-type zinc finger//B-box zinc finger//BED zinc finger//LIM domain GO:0006464 cellular protein modification process GO:0016151//GO:0046872//GO:0008270//GO:0003676//GO:0003677 nickel cation binding//metal ion binding//zinc ion binding//nucleic acid binding//DNA binding GO:0005622 intracellular KOG1721 FOG: Zn-finger Cluster-8309.15314 BP_3 2.00 1.52 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15315 BP_3 68.11 1.48 2506 642929025 XP_008195660.1 827 2.1e-85 PREDICTED: probable maleylacetoacetate isomerase 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01800 maiA, GSTZ1 maleylacetoacetate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01800 Q9VHD2 785 6.3e-82 Probable maleylacetoacetate isomerase 2 OS=Drosophila melanogaster GN=GstZ2 PE=1 SV=1 PF13409//PF02798//PF00462//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0009055//GO:0015035//GO:0005515 electron carrier activity//protein disulfide oxidoreductase activity//protein binding -- -- KOG0868 Glutathione S-transferase Cluster-8309.15316 BP_3 10.36 1.49 626 91091194 XP_972244.1 205 6.9e-14 PREDICTED: superoxide dismutase [Cu-Zn] [Tribolium castaneum]>gi|270014236|gb|EFA10684.1| hypothetical protein TcasGA2_TC011675 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0004784//GO:0046872 superoxide dismutase activity//metal ion binding -- -- -- -- Cluster-8309.15317 BP_3 202.70 2.16 4823 646723340 KDR23974.1 697 4.7e-70 Stathmin [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q09002 147 1.2e-07 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF13741//PF00318//PF08496//PF06667//PF01544//PF01442//PF14372//PF08074//PF01956//PF02096//PF00836 Mitochondrial ribosomal protein S25//Ribosomal protein S2//Peptidase family S49 N-terminal//Phage shock protein B//CorA-like Mg2+ transporter protein//Apolipoprotein A1/A4/E domain//Domain of unknown function (DUF4413)//CHDCT2 (NUC038) domain//Integral membrane protein DUF106//60Kd inner membrane protein//Stathmin family GO:0042157//GO:0030001//GO:0006412//GO:0006869//GO:0031110//GO:0006355//GO:0042254//GO:0009271//GO:0055085//GO:0051205 lipoprotein metabolic process//metal ion transport//translation//lipid transport//regulation of microtubule polymerization or depolymerization//regulation of transcription, DNA-templated//ribosome biogenesis//phage shock//transmembrane transport//protein insertion into membrane GO:0046873//GO:0003677//GO:0008289//GO:0003735//GO:0008270//GO:0004252//GO:0016818//GO:0005524 metal ion transmembrane transporter activity//DNA binding//lipid binding//structural constituent of ribosome//zinc ion binding//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding GO:0016020//GO:0005576//GO:0005763//GO:0005886//GO:0005634//GO:0005622//GO:0005840//GO:0016021 membrane//extracellular region//mitochondrial small ribosomal subunit//plasma membrane//nucleus//intracellular//ribosome//integral component of membrane -- -- Cluster-8309.15322 BP_3 1.00 1.80 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.15323 BP_3 2.01 0.32 596 156543479 XP_001601687.1 321 2.3e-27 PREDICTED: phosphoglucomutase-2 [Nasonia vitripennis]>gi|345495393|ref|XP_003427498.1| PREDICTED: phosphoglucomutase-2 [Nasonia vitripennis]>gi|645016001|ref|XP_008211299.1| PREDICTED: phosphoglucomutase-2 [Nasonia vitripennis]>gi|645016005|ref|XP_008211301.1| PREDICTED: phosphoglucomutase-2 [Nasonia vitripennis]>gi|645016007|ref|XP_008211302.1| PREDICTED: phosphoglucomutase-2 [Nasonia vitripennis]>gi|645016009|ref|XP_008211303.1| PREDICTED: phosphoglucomutase-2 [Nasonia vitripennis]>gi|645016011|ref|XP_008211304.1| PREDICTED: phosphoglucomutase-2 [Nasonia vitripennis] -- -- -- -- -- K15779 PGM2 phosphoglucomutase / phosphopentomutase http://www.genome.jp/dbget-bin/www_bget?ko:K15779 Q7TSV4 261 8.6e-22 Phosphoglucomutase-2 OS=Mus musculus GN=Pgm2 PE=1 SV=1 PF16711//PF00408 Actin-binding domain of plant-specific actin-binding protein//Phosphoglucomutase/phosphomannomutase, C-terminal domain GO:0071704 organic substance metabolic process GO:0016868//GO:0003779 intramolecular transferase activity, phosphotransferases//actin binding -- -- KOG1220 Phosphoglucomutase/phosphomannomutase Cluster-8309.15326 BP_3 79.89 1.66 2616 91077384 XP_975249.1 1307 4.7e-141 PREDICTED: protoporphyrinogen oxidase [Tribolium castaneum]>gi|270001648|gb|EEZ98095.1| hypothetical protein TcasGA2_TC000508 [Tribolium castaneum] -- -- -- -- -- K00231 PPOX, hemY oxygen-dependent protoporphyrinogen oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00231 P51175 757 1.2e-78 Protoporphyrinogen oxidase OS=Mus musculus GN=Ppox PE=1 SV=1 PF03144//PF07992//PF02269//PF01266//PF00070//PF12831//PF01593 Elongation factor Tu domain 2//Pyridine nucleotide-disulphide oxidoreductase//Transcription initiation factor IID, 18kD subunit//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase GO:0008152//GO:0006366//GO:0055114 metabolic process//transcription from RNA polymerase II promoter//oxidation-reduction process GO:0005525//GO:0016491 GTP binding//oxidoreductase activity -- -- KOG3901 Transcription initiation factor IID subunit Cluster-8309.15328 BP_3 3.00 0.67 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15329 BP_3 28.19 1.04 1593 642912555 XP_008200909.1 310 1.2e-25 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X1 [Tribolium castaneum]>gi|270002604|gb|EEZ99051.1| hypothetical protein TcasGA2_TC004926 [Tribolium castaneum] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q8BSF4 184 2.0e-12 Phosphatidylserine decarboxylase proenzyme OS=Mus musculus GN=Pisd PE=2 SV=1 -- -- GO:0006566//GO:0006563//GO:0006544//GO:0008654//GO:0046486 threonine metabolic process//L-serine metabolic process//glycine metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.15330 BP_3 16.00 0.46 1974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15333 BP_3 69.66 0.50 7020 642917395 XP_008191178.1 2504 2.0e-279 PREDICTED: DNA ligase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 P51892 2116 8.1e-236 DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1 PF00515//PF04675//PF04679//PF01331//PF13414//PF13181//PF01068//PF13174//PF03971 Tetratricopeptide repeat//DNA ligase N terminus//ATP dependent DNA ligase C terminal region//mRNA capping enzyme, catalytic domain//TPR repeat//Tetratricopeptide repeat//ATP dependent DNA ligase domain//Tetratricopeptide repeat//Monomeric isocitrate dehydrogenase GO:0019643//GO:0006281//GO:0006749//GO:0006397//GO:0055114//GO:0006310//GO:0006370//GO:0006099//GO:0006260 reductive tricarboxylic acid cycle//DNA repair//glutathione metabolic process//mRNA processing//oxidation-reduction process//DNA recombination//7-methylguanosine mRNA capping//tricarboxylic acid cycle//DNA replication GO:0004484//GO:0005515//GO:0005524//GO:0003677//GO:0004450//GO:0003910 mRNA guanylyltransferase activity//protein binding//ATP binding//DNA binding//isocitrate dehydrogenase (NADP+) activity//DNA ligase (ATP) activity -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.15336 BP_3 710.05 13.99 2738 642933410 XP_008197405.1 2316 4.9e-258 PREDICTED: sodium-independent sulfate anion transporter isoform X2 [Tribolium castaneum] 644991717 XM_001603675.3 264 2.16755e-133 PREDICTED: Nasonia vitripennis sodium-independent sulfate anion transporter (LOC100120043), mRNA K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 959 4.6e-102 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.15338 BP_3 8.00 0.41 1223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15339 BP_3 13.66 1.16 857 642931629 XP_008196662.1 257 8.8e-20 PREDICTED: broad-complex core protein isoform 6-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF13912//PF02892//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.15340 BP_3 4.00 0.49 682 746837581 XP_011049295.1 157 2.8e-08 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15341 BP_3 10.76 2.45 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15343 BP_3 10.00 1.49 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15344 BP_3 9.80 0.77 901 642912701 XP_970424.2 588 3.8e-58 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q7XJS0 170 4.7e-11 Histone-lysine N-methyltransferase ASHR1 OS=Arabidopsis thaliana GN=ASHR1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.15345 BP_3 14.42 0.82 1140 642912701 XP_970424.2 694 2.5e-70 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q7XJS0 288 1.2e-24 Histone-lysine N-methyltransferase ASHR1 OS=Arabidopsis thaliana GN=ASHR1 PE=2 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.15347 BP_3 37.27 1.29 1681 91079358 XP_970171.1 573 3.9e-56 PREDICTED: ankyrin repeat domain-containing protein 54 [Tribolium castaneum]>gi|270003493|gb|EEZ99940.1| hypothetical protein TcasGA2_TC002736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NXT1 323 1.6e-28 Ankyrin repeat domain-containing protein 54 OS=Homo sapiens GN=ANKRD54 PE=1 SV=2 PF13606//PF00023//PF00831 Ankyrin repeat//Ankyrin repeat//Ribosomal L29 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.15351 BP_3 485.28 8.09 3182 808861794 KKF13591.1 334 3.9e-28 Zinc finger protein 235 [Larimichthys crocea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q3ZCX4 316 1.9e-27 Zinc finger protein 568 OS=Homo sapiens GN=ZNF568 PE=2 SV=2 PF10389//PF13465//PF00096//PF06220//PF13912//PF05191//PF07776 Bacteriophage coat protein B//Zinc-finger double domain//Zinc finger, C2H2 type//U1 zinc finger//C2H2-type zinc finger//Adenylate kinase, active site lid//Zinc-finger associated domain (zf-AD) GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0046872//GO:0004017//GO:0008270 metal ion binding//adenylate kinase activity//zinc ion binding GO:0019028//GO:0005634 viral capsid//nucleus -- -- Cluster-8309.15358 BP_3 6.68 0.32 1301 478252462 ENN72884.1 506 1.8e-48 hypothetical protein YQE_10454, partial [Dendroctonus ponderosae]>gi|546682580|gb|ERL92499.1| hypothetical protein D910_09812 [Dendroctonus ponderosae] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 422 4.0e-40 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 PF12162 STAT1 TAZ2 binding domain -- -- GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.1536 BP_3 3.00 0.62 525 444730664 ELW71038.1 813 1.8e-84 40S ribosomal protein S19 [Tupaia chinensis] 33875112 BC000023.2 501 0 Homo sapiens ribosomal protein S19, mRNA (cDNA clone MGC:1630 IMAGE:3504083), complete cds K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 Q32PD5 748 2.6e-78 40S ribosomal protein S19 OS=Bos taurus GN=RPS19 PE=2 SV=3 PF01090//PF09339 Ribosomal protein S19e//IclR helix-turn-helix domain GO:0006355//GO:0006412//GO:0042254 regulation of transcription, DNA-templated//translation//ribosome biogenesis GO:0003677//GO:0003735 DNA binding//structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.15365 BP_3 189.27 4.90 2153 546676764 ERL87718.1 2118 3.5e-235 hypothetical protein D910_05108 [Dendroctonus ponderosae] 195122271 XM_002005600.1 48 2.01411e-13 Drosophila mojavensis GI18963 (Dmoj\GI18963), mRNA K08588 BAP1, UCHL2 ubiquitin carboxyl-terminal hydrolase BAP1 http://www.genome.jp/dbget-bin/www_bget?ko:K08588 Q17N72 1040 1.5e-111 Ubiquitin carboxyl-terminal hydrolase calypso OS=Aedes aegypti GN=calypso PE=3 SV=1 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006511//GO:0006508//GO:0016579 ubiquitin-dependent protein catabolic process//proteolysis//protein deubiquitination GO:0004843 ubiquitin-specific protease activity GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.15366 BP_3 353.43 4.20 4348 562874119 XP_006164934.1 411 6.2e-37 PREDICTED: zinc finger protein 717-like [Tupaia chinensis] 642932060 XM_008198621.1 176 2.87007e-84 PREDICTED: Tribolium castaneum protein lin-54 homolog (LOC663835), transcript variant X3, mRNA -- -- -- -- Q6P560 406 9.7e-38 Zinc finger protein 182 OS=Mus musculus GN=Znf182 PE=2 SV=1 PF13465//PF00096//PF07975//PF13912//PF00412//PF16622//PF01428 Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain//C2H2-type zinc finger//LIM domain//zinc-finger C2H2-type//AN1-like Zinc finger GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.15371 BP_3 12.00 0.97 889 665796911 XP_008546264.1 248 1.0e-18 PREDICTED: dnaJ homolog subfamily B member 12 [Microplitis demolitor]>gi|607304256|gb|EZA45503.1| dnaJ subfamily B member 12-like protein [Microplitis demolitor] -- -- -- -- -- K09518 DNAJB12 DnaJ homolog subfamily B member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09518 Q9CZJ9 134 6.9e-07 DnaJ homolog subfamily C member 18 OS=Mus musculus GN=Dnajc18 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.15372 BP_3 409.00 7.46 2933 478257763 ENN77906.1 2103 2.7e-233 hypothetical protein YQE_05583, partial [Dendroctonus ponderosae] -- -- -- -- -- K15255 PIF1 ATP-dependent DNA helicase PIF1 http://www.genome.jp/dbget-bin/www_bget?ko:K15255 Q0R4F1 1295 5.4e-141 ATP-dependent DNA helicase PIF1 OS=Xenopus laevis GN=pif1 PE=2 SV=1 PF00005//PF03193//PF02689//PF02562//PF00270//PF05970//PF07728//PF01443//PF00004 ABC transporter//Protein of unknown function, DUF258//Helicase//PhoH-like protein//DEAD/DEAH box helicase//PIF1-like helicase//AAA domain (dynein-related subfamily)//Viral (Superfamily 1) RNA helicase//ATPase family associated with various cellular activities (AAA) GO:0006281//GO:0000723 DNA repair//telomere maintenance GO:0003678//GO:0005524//GO:0004386//GO:0003924//GO:0003676//GO:0016887//GO:0005525 DNA helicase activity//ATP binding//helicase activity//GTPase activity//nucleic acid binding//ATPase activity//GTP binding GO:0005657 replication fork KOG0987 DNA helicase PIF1/RRM3 Cluster-8309.15373 BP_3 4.82 0.47 782 642926566 XP_008194923.1 343 8.6e-30 PREDICTED: PP2C-like domain-containing protein CG9801 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0KIA2 222 3.8e-17 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228 Stage II sporulation protein E (SpoIIE) -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.15375 BP_3 205.29 2.27 4649 676426419 XP_009044617.1 831 1.3e-85 hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea]>gi|556116066|gb|ESP04718.1| hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 765 2.4e-79 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF16622//PF13912//PF01842//PF00130//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//ACT domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556//GO:0008152 intracellular signal transduction//metabolic process GO:0046872//GO:0016597 metal ion binding//amino acid binding -- -- -- -- Cluster-8309.15376 BP_3 293.31 9.67 1754 91084417 XP_967827.1 524 2.0e-50 PREDICTED: chromobox protein homolog 3 [Tribolium castaneum]>gi|270008703|gb|EFA05151.1| hypothetical protein TcasGA2_TC015268 [Tribolium castaneum] 242011614 XM_002426498.1 40 4.5773e-09 Pediculus humanus corporis hypothetical protein, mRNA K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83916 399 2.5e-37 Chromobox protein homolog 1 OS=Homo sapiens GN=CBX1 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.15377 BP_3 199.69 6.91 1685 91084417 XP_967827.1 524 1.9e-50 PREDICTED: chromobox protein homolog 3 [Tribolium castaneum]>gi|270008703|gb|EFA05151.1| hypothetical protein TcasGA2_TC015268 [Tribolium castaneum] 242011614 XM_002426498.1 40 4.39357e-09 Pediculus humanus corporis hypothetical protein, mRNA K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83917 399 2.4e-37 Chromobox protein homolog 1 OS=Mus musculus GN=Cbx1 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.15378 BP_3 70.00 6.29 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.15380 BP_3 1.00 0.58 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15381 BP_3 1.00 6.33 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15382 BP_3 219.79 2.29 4927 642911878 XP_008199004.1 2614 2.5e-292 PREDICTED: zinc finger protein basonuclin-2-like [Tribolium castaneum] 642911877 XM_008200782.1 487 0 PREDICTED: Tribolium castaneum zinc finger protein basonuclin-2-like (LOC660322), mRNA -- -- -- -- Q6ZN30 524 2.3e-51 Zinc finger protein basonuclin-2 OS=Homo sapiens GN=BNC2 PE=1 SV=1 PF00096//PF02892 Zinc finger, C2H2 type//BED zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.15383 BP_3 64.21 0.68 4829 270015097 EFA11545.1 2614 2.4e-292 disco-related [Tribolium castaneum] 642911877 XM_008200782.1 487 0 PREDICTED: Tribolium castaneum zinc finger protein basonuclin-2-like (LOC660322), mRNA -- -- -- -- Q6ZN30 524 2.2e-51 Zinc finger protein basonuclin-2 OS=Homo sapiens GN=BNC2 PE=1 SV=1 PF02892//PF00096 BED zinc finger//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.15388 BP_3 26.00 5.84 506 294860856 ADF45324.1 471 7.9e-45 ubiquitin/ribosomal S30 fusion protein [Eriocheir sinensis] -- -- -- -- -- K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 P0C2F0 174 9.0e-12 40S ribosomal protein S30 OS=Pongo abelii GN=FAU PE=3 SV=1 PF04758 Ribosomal protein S30 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0009 Ubiquitin-like/40S ribosomal S30 protein fusion Cluster-8309.15389 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15391 BP_3 8.00 1.01 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15397 BP_3 3.50 1.01 459 642926488 XP_008191976.1 320 2.3e-27 PREDICTED: probable ATP-dependent RNA helicase kurz [Tribolium castaneum]>gi|270009095|gb|EFA05543.1| hypothetical protein TcasGA2_TC015731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46072 127 2.3e-06 Probable ATP-dependent RNA helicase kurz OS=Drosophila melanogaster GN=kz PE=1 SV=1 -- -- -- -- GO:1901363//GO:0016787//GO:0097159 heterocyclic compound binding//hydrolase activity//organic cyclic compound binding -- -- -- -- Cluster-8309.15400 BP_3 1009.72 26.93 2099 642925170 XP_008194455.1 1610 2.8e-176 PREDICTED: endoglucanase 5-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5YLG1 869 9.6e-92 Endoglucanase A OS=Bacillus pumilus GN=eglA PE=1 SV=1 PF00759//PF09204 Glycosyl hydrolase family 9//Bacterial self-protective colicin-like immunity GO:0005975//GO:0006955//GO:0030153 carbohydrate metabolic process//immune response//bacteriocin immunity GO:0015643//GO:0004553 toxic substance binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0019814 immunoglobulin complex -- -- Cluster-8309.15406 BP_3 173.00 6.71 1534 642921376 XP_008192841.1 431 1.0e-39 PREDICTED: uncharacterized protein LOC103312859 [Tribolium castaneum]>gi|270006270|gb|EFA02718.1| hypothetical protein TcasGA2_TC008442 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15408 BP_3 134.10 2.01 3510 478261830 ENN80953.1 638 2.4e-63 hypothetical protein YQE_02658, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15409 BP_3 23.00 0.66 1974 478255734 ENN75943.1 514 3.2e-49 hypothetical protein YQE_07478, partial [Dendroctonus ponderosae]>gi|546683611|gb|ERL93399.1| hypothetical protein D910_10691 [Dendroctonus ponderosae] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 Q5ZKA5 430 7.3e-41 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Gallus gallus GN=MTHFD2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.15410 BP_3 787.80 34.83 1382 478255734 ENN75943.1 1150 4.0e-123 hypothetical protein YQE_07478, partial [Dendroctonus ponderosae]>gi|546683611|gb|ERL93399.1| hypothetical protein D910_10691 [Dendroctonus ponderosae] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 Q0P5C2 877 7.5e-93 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus GN=MTHFD2 PE=2 SV=1 PF00763//PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0055114//GO:0046487//GO:0009396 oxidation-reduction process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.15411 BP_3 83.00 3.82 1340 642933815 XP_008197379.1 775 1.2e-79 PREDICTED: protein FAM86D [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1JPJ9 336 3.9e-30 Protein-lysine N-methyltransferase EEF2KMT OS=Bos taurus GN=EEF2KMT PE=2 SV=2 PF05175 Methyltransferase small domain -- -- GO:0008168 methyltransferase activity -- -- KOG2497 Predicted methyltransferase Cluster-8309.15413 BP_3 43.18 5.64 661 662197889 XP_008472044.1 628 6.5e-63 PREDICTED: adrenodoxin-like protein, mitochondrial [Diaphorina citri]>gi|662197891|ref|XP_008472045.1| PREDICTED: adrenodoxin-like protein, mitochondrial [Diaphorina citri]>gi|662197893|ref|XP_008472047.1| PREDICTED: adrenodoxin-like protein, mitochondrial [Diaphorina citri] 645007869 XM_001600661.3 119 2.02712e-53 PREDICTED: Nasonia vitripennis adrenodoxin-like protein, mitochondrial (LOC100118135), mRNA -- -- -- -- P37193 568 2.4e-57 Adrenodoxin-like protein, mitochondrial OS=Drosophila melanogaster GN=Fdxh PE=2 SV=3 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0009055//GO:0051536 electron carrier activity//iron-sulfur cluster binding -- -- KOG3309 Ferredoxin Cluster-8309.15414 BP_3 4.00 0.41 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15416 BP_3 60.00 6.23 756 91080437 XP_968816.1 678 1.2e-68 PREDICTED: metallo-beta-lactamase domain-containing protein 1 [Tribolium castaneum]>gi|270005573|gb|EFA02021.1| hypothetical protein TcasGA2_TC007644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q498J9 335 2.9e-30 Metallo-beta-lactamase domain-containing protein 1 OS=Xenopus laevis GN=mblac1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4736 Uncharacterized conserved protein Cluster-8309.15418 BP_3 21.06 0.43 2673 645021685 XP_008207623.1 473 2.5e-44 PREDICTED: sodium channel protein Nach [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q9VL84 225 5.8e-17 Pickpocket protein 11 OS=Drosophila melanogaster GN=ppk11 PE=2 SV=2 PF15168//PF00858 Triple QxxK/R motif-containing protein family//Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020//GO:0005789 membrane//endoplasmic reticulum membrane -- -- Cluster-8309.15420 BP_3 374.57 9.32 2228 642934956 XP_008195951.1 2060 1.9e-228 PREDICTED: TNF receptor-associated factor 4 isoform X3 [Tribolium castaneum] 817199300 XM_012419904.1 272 6.28467e-138 PREDICTED: Orussus abietinus TNF receptor-associated factor 4 (LOC105696990), transcript variant X2, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 1177 2.0e-127 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF03145//PF15965//PF00096//PF02176 Seven in absentia protein family//TRAF-like zinc-finger//Zinc finger, C2H2 type//TRAF-type zinc finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG0297 TNF receptor-associated factor Cluster-8309.15423 BP_3 44.00 2.32 1207 546674258 ERL85677.1 744 4.2e-76 hypothetical protein D910_03093 [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q55E31 467 2.3e-45 Ras-related protein Rab-32B OS=Dictyostelium discoideum GN=rab32B PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15428 BP_3 202.74 5.33 2124 189234613 XP_001816367.1 502 8.5e-48 PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913888|ref|XP_008201202.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913890|ref|XP_008201203.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|270001651|gb|EEZ98098.1| hypothetical protein TcasGA2_TC000511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15429 BP_3 63.26 1.83 1961 189234613 XP_001816367.1 502 7.8e-48 PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913888|ref|XP_008201202.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913890|ref|XP_008201203.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|270001651|gb|EEZ98098.1| hypothetical protein TcasGA2_TC000511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15433 BP_3 75.46 1.21 3301 478263032 ENN81432.1 566 5.0e-55 hypothetical protein YQE_02125, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V8F7 227 4.2e-17 Coiled-coil domain-containing protein 63 OS=Rattus norvegicus GN=Ccdc63 PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0003723//GO:0043022//GO:0003746 RNA binding//ribosome binding//translation elongation factor activity GO:0005840 ribosome -- -- Cluster-8309.15434 BP_3 33.14 0.52 3368 478263032 ENN81432.1 444 7.2e-41 hypothetical protein YQE_02125, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V8F7 170 1.7e-10 Coiled-coil domain-containing protein 63 OS=Rattus norvegicus GN=Ccdc63 PE=2 SV=1 PF14942//PF01287//PF09728 Organelle biogenesis, Muted-like protein//Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//Myosin-like coiled-coil protein GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0019905//GO:0003723//GO:0043022//GO:0003746 syntaxin binding//RNA binding//ribosome binding//translation elongation factor activity GO:0031083//GO:0030133//GO:0005840 BLOC-1 complex//transport vesicle//ribosome -- -- Cluster-8309.15438 BP_3 16.00 0.86 1188 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15439 BP_3 6.00 1.38 501 642935586 XP_008198071.1 174 2.2e-10 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform M isoform X9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15444 BP_3 1.00 1.22 320 385145418 CCG28034.1 553 1.6e-54 beta tubulin 1 [Sepia officinalis] 655881817 XM_002720955.2 199 3.13238e-98 PREDICTED: Oryctolagus cuniculus tubulin, beta 2B class IIb (TUBB2B), mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q6P9T8 551 1.1e-55 Tubulin beta-4B chain OS=Rattus norvegicus GN=Tubb4b PE=1 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.15445 BP_3 22.48 0.71 1826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1545 BP_3 3.00 0.64 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02022 Integrase Zinc binding domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.15452 BP_3 1.28 0.96 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15453 BP_3 32.86 0.52 3329 642917749 XP_008191355.1 1710 1.1e-187 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q179T2 531 2.4e-52 Exonuclease mut-7 homolog OS=Aedes aegypti GN=AAEL005527 PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding -- -- KOG2207 Predicted 3'-5' exonuclease Cluster-8309.15456 BP_3 246.50 10.59 1414 91090910 XP_973922.1 1130 8.6e-121 PREDICTED: protein rogdi isoform X1 [Tribolium castaneum]>gi|270013221|gb|EFA09669.1| hypothetical protein TcasGA2_TC011795 [Tribolium castaneum] 805780431 XM_012283623.1 73 1.66073e-27 PREDICTED: Megachile rotundata protein rogdi (LOC100879337), transcript variant X2, mRNA -- -- -- -- Q9VVE2 833 9.7e-88 Protein rogdi OS=Drosophila melanogaster GN=rogdi PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3992 Uncharacterized conserved protein Cluster-8309.15457 BP_3 22.00 0.61 2032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15461 BP_3 43.12 1.39 1782 642923022 XP_008200499.1 709 7.1e-72 PREDICTED: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62377 381 3.2e-35 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 OS=Mus musculus GN=Zrsr2 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2202 U2 snRNP splicing factor, small subunit, and related proteins Cluster-8309.15466 BP_3 5.00 1.15 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15467 BP_3 936.03 27.66 1923 642931074 XP_974160.2 683 7.9e-69 PREDICTED: stimulator of interferon genes protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TBT3 199 4.3e-14 Stimulator of interferon genes protein OS=Mus musculus GN=Tmem173 PE=1 SV=2 PF15009 Transmembrane protein 173 GO:0002218//GO:0032481 activation of innate immune response//positive regulation of type I interferon production -- -- -- -- -- -- Cluster-8309.15472 BP_3 57.58 0.84 3603 270003759 EFA00207.1 1132 1.3e-120 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.29439e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.3e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.15475 BP_3 162.97 8.10 1261 91094761 XP_966940.1 634 2.5e-63 PREDICTED: trafficking protein particle complex subunit 1 [Tribolium castaneum]>gi|270016552|gb|EFA12998.1| hypothetical protein TcasGA2_TC001478 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5NCF2 480 7.4e-47 Trafficking protein particle complex subunit 1 OS=Mus musculus GN=Trappc1 PE=1 SV=1 PF04628//PF04099 Sedlin, N-terminal conserved region//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005622//GO:0005801 intracellular//cis-Golgi network KOG3368 Transport protein particle (TRAPP) complex subunit Cluster-8309.15476 BP_3 27.03 1.26 1329 332376354 AEE63317.1 479 2.5e-45 unknown [Dendroctonus ponderosae]>gi|478255104|gb|ENN75334.1| hypothetical protein YQE_08110, partial [Dendroctonus ponderosae]>gi|546680136|gb|ERL90477.1| hypothetical protein D910_07826 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5NCF2 368 7.5e-34 Trafficking protein particle complex subunit 1 OS=Mus musculus GN=Trappc1 PE=1 SV=1 PF04628//PF04099 Sedlin, N-terminal conserved region//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3368 Transport protein particle (TRAPP) complex subunit Cluster-8309.15479 BP_3 1.00 0.31 445 283855668 ADB45159.1 147 2.6e-07 transposase [Pectinophora gossypiella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1548 BP_3 1.00 1.32 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15482 BP_3 1.00 6.33 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15484 BP_3 13.00 1.31 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15486 BP_3 25.54 2.40 805 91093076 XP_968784.1 693 2.3e-70 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 584 4.1e-59 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.15488 BP_3 136.00 9.15 1008 642923784 XP_974439.3 385 1.5e-34 PREDICTED: probable 28S ribosomal protein S26, mitochondrial [Tribolium castaneum]>gi|270006944|gb|EFA03392.1| hypothetical protein TcasGA2_TC013378 [Tribolium castaneum] -- -- -- -- -- K17405 MRPS26 small subunit ribosomal protein S26 http://www.genome.jp/dbget-bin/www_bget?ko:K17405 Q9VVN2 316 6.1e-28 Probable 28S ribosomal protein S26, mitochondrial OS=Drosophila melanogaster GN=mRpS26 PE=2 SV=1 PF14943//PF12328//PF02482 Mitochondrial ribosome subunit S26//Rpp20 subunit of nuclear RNase MRP and P//Sigma 54 modulation protein / S30EA ribosomal protein GO:0051252//GO:0008033//GO:0044238 regulation of RNA metabolic process//tRNA processing//primary metabolic process GO:0004526 ribonuclease P activity GO:0030677//GO:0005763//GO:0005634 ribonuclease P complex//mitochondrial small ribosomal subunit//nucleus -- -- Cluster-8309.1549 BP_3 4.89 0.33 1005 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15490 BP_3 37.04 0.53 3680 646702401 KDR11613.1 2159 1.1e-239 Mothers against decapentaplegic-like protein 4 [Zootermopsis nevadensis] 552954715 KF307635.1 131 2.51278e-59 Pinctada fucata TGF beta signaling pathway factor (smad4) mRNA, complete cds K04501 SMAD4 mothers against decapentaplegic homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04501 Q9GKQ9 1075 2.2e-115 Mothers against decapentaplegic homolog 4 OS=Sus scrofa GN=SMAD4 PE=2 SV=1 PF03165//PF03166 MH1 domain//MH2 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.15491 BP_3 586.25 8.25 3717 646702401 KDR11613.1 2159 1.1e-239 Mothers against decapentaplegic-like protein 4 [Zootermopsis nevadensis] 552954715 KF307635.1 131 2.53829e-59 Pinctada fucata TGF beta signaling pathway factor (smad4) mRNA, complete cds K04501 SMAD4 mothers against decapentaplegic homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04501 Q9GKQ9 1075 2.2e-115 Mothers against decapentaplegic homolog 4 OS=Sus scrofa GN=SMAD4 PE=2 SV=1 PF03166//PF03165 MH2 domain//MH1 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.15492 BP_3 19.00 0.49 2179 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15493 BP_3 10.84 0.59 1182 189239355 XP_974286.2 1092 1.8e-116 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 868 7.1e-92 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 PF00270//PF00622 DEAD/DEAH box helicase//SPRY domain -- -- GO:0003676//GO:0005524//GO:0005515//GO:0008026 nucleic acid binding//ATP binding//protein binding//ATP-dependent helicase activity -- -- KOG0349 Putative DEAD-box RNA helicase DDX1 Cluster-8309.15495 BP_3 42.93 0.47 4671 642918668 XP_008191531.1 1185 1.2e-126 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum]>gi|642918670|ref|XP_008191532.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15499 BP_3 362.53 9.53 2126 642936794 XP_008199618.1 257 2.2e-19 PREDICTED: protein kish-A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWH8 236 2.4e-18 Protein kish OS=Drosophila melanogaster GN=ksh PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1550 BP_3 9.00 0.54 1091 -- -- -- -- -- 768311759 CP010987.1 1062 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- Q9P3B2 142 1.0e-07 Respiratory supercomplex factor 2 homolog C1565.01 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rcf2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15500 BP_3 2.00 0.86 403 426374315 XP_004054021.1 677 8.2e-69 PREDICTED: 40S ribosomal protein S2-like isoform 1 [Gorilla gorilla gorilla]>gi|426374317|ref|XP_004054022.1| PREDICTED: 40S ribosomal protein S2-like isoform 2 [Gorilla gorilla gorilla]>gi|426374319|ref|XP_004054023.1| PREDICTED: 40S ribosomal protein S2-like isoform 3 [Gorilla gorilla gorilla]>gi|426374321|ref|XP_004054024.1| PREDICTED: 40S ribosomal protein S2-like isoform 4 [Gorilla gorilla gorilla] 42542642 BC066321.1 403 0 Homo sapiens ribosomal protein S2, mRNA (cDNA clone MGC:87212 IMAGE:5296344), complete cds K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 O18789 638 1.1e-65 40S ribosomal protein S2 OS=Bos taurus GN=RPS2 PE=2 SV=2 PF03719 Ribosomal protein S5, C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.15508 BP_3 35.25 1.43 1479 189241797 XP_001812480.1 207 9.5e-14 PREDICTED: cytochrome c oxidase subunit 6C [Tribolium castaneum]>gi|270001250|gb|EEZ97697.1| hypothetical protein TcasGA2_TC011006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.1551 BP_3 34.00 37.41 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15512 BP_3 17.07 0.46 2087 189239087 XP_968222.2 820 1.1e-84 PREDICTED: DNA polymerase epsilon subunit 2 [Tribolium castaneum] -- -- -- -- -- K02325 POLE2 DNA polymerase epsilon subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02325 O54956 511 3.1e-50 DNA polymerase epsilon subunit 2 OS=Mus musculus GN=Pole2 PE=2 SV=2 PF05132//PF04042 RNA polymerase III RPC4//DNA polymerase alpha/epsilon subunit B GO:0006351//GO:0006383//GO:0006144//GO:0006206//GO:0006260 transcription, DNA-templated//transcription from RNA polymerase III promoter//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//DNA replication GO:0003677//GO:0003899//GO:0003887 DNA binding//DNA-directed RNA polymerase activity//DNA-directed DNA polymerase activity GO:0042575//GO:0005666//GO:0005730 DNA polymerase complex//DNA-directed RNA polymerase III complex//nucleolus KOG3818 DNA polymerase epsilon, subunit B Cluster-8309.15513 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15514 BP_3 19.00 0.88 1329 270009040 EFA05488.1 248 1.5e-18 hypothetical protein TcasGA2_TC015673 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q29RZ2 200 2.3e-14 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Bos taurus GN=PPWD1 PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.1552 BP_3 65.00 6.40 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06134 L-rhamnose isomerase (RhaA) GO:0019299//GO:0006000//GO:0006013 rhamnose metabolic process//fructose metabolic process//mannose metabolic process GO:0030145//GO:0008740 manganese ion binding//L-rhamnose isomerase activity -- -- -- -- Cluster-8309.15522 BP_3 23.00 2.01 842 270016418 EFA12864.1 256 1.1e-19 hypothetical protein TcasGA2_TC004246 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15523 BP_3 53.00 1.25 2342 642939272 XP_008192906.1 209 8.9e-14 PREDICTED: polycomb group protein Psc-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1553 BP_3 67.41 6.09 825 270004698 EFA01146.1 215 6.3e-15 hypothetical protein TcasGA2_TC010371 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15532 BP_3 1.00 0.34 433 -- -- -- -- -- 642917441 XM_008192979.1 36 1.78342e-07 PREDICTED: Tribolium castaneum jerky protein homolog-like (LOC103312418), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15533 BP_3 11.63 0.73 1059 546679575 ERL90023.1 671 1.1e-67 hypothetical protein D910_07381, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGC3 222 5.1e-17 Conserved oligomeric Golgi complex subunit 1 OS=Drosophila melanogaster GN=CG4848 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15536 BP_3 179.00 5.09 1987 642927610 XP_008195334.1 1859 3.5e-205 PREDICTED: conserved oligomeric Golgi complex subunit 1 [Tribolium castaneum]>gi|270011053|gb|EFA07501.1| pebbled [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z160 413 6.8e-39 Conserved oligomeric Golgi complex subunit 1 OS=Mus musculus GN=Cog1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2033 Low density lipoprotein B-like protein Cluster-8309.15537 BP_3 8.86 0.33 1600 546679575 ERL90023.1 671 1.6e-67 hypothetical protein D910_07381, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Z160 223 5.9e-17 Conserved oligomeric Golgi complex subunit 1 OS=Mus musculus GN=Cog1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15540 BP_3 5.00 0.97 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02918 Pertussis toxin, subunit 2 and 3, C-terminal domain GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.15545 BP_3 1.66 0.32 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15550 BP_3 5.00 0.33 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15552 BP_3 5.00 0.31 1061 124505939 XP_001351567.1 184 3.2e-11 Mature parasite-infected erythrocyte surface antigen (MESA) or PfEMP2 [Plasmodium falciparum 3D7]>gi|23504494|emb|CAD51374.1| Mature parasite-infected erythrocyte surface antigen (MESA) or PfEMP2 [Plasmodium falciparum 3D7] -- -- -- -- -- -- -- -- -- Q54J55 145 4.3e-08 Myb-like protein X OS=Dictyostelium discoideum GN=mybX PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15555 BP_3 7.55 0.47 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15556 BP_3 15.00 0.42 2006 646696203 KDR08650.1 529 5.9e-51 Programmed cell death protein 4 [Zootermopsis nevadensis] -- -- -- -- -- K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 414 5.3e-39 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.15560 BP_3 8.00 1.64 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15561 BP_3 369.00 24.03 1032 478260709 ENN80392.1 211 2.3e-14 hypothetical protein YQE_03184, partial [Dendroctonus ponderosae]>gi|546683578|gb|ERL93376.1| hypothetical protein D910_10668 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4IAB8 142 9.4e-08 Vacuolar ATPase assembly integral membrane protein VMA21 homolog OS=Drosophila sechellia GN=GM22297 PE=3 SV=1 PF09446 VMA21-like domain GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly -- -- -- -- -- -- Cluster-8309.15562 BP_3 2.00 0.60 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15567 BP_3 7.00 1.64 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1557 BP_3 1.00 0.59 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15572 BP_3 15.96 0.60 1572 270014160 EFA10608.1 1189 1.4e-127 hypothetical protein TcasGA2_TC012869 [Tribolium castaneum] 642936636 XM_008200296.1 81 6.61048e-32 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 12 (LOC661906), mRNA -- -- -- -- Q24206 398 3.0e-37 Broad-complex core protein isoform 6 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF13912//PF02892//PF16622//PF00651//PF13465//PF00096 C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//BTB/POZ domain//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.15575 BP_3 286.31 2.67 5453 642924251 XP_008194216.1 4280 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19464 PLEKHG5 pleckstrin homology domain-containing family G member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K19464 Q6RFZ7 762 6.4e-79 Pleckstrin homology domain-containing family G member 5 OS=Rattus norvegicus GN=Plekhg5 PE=1 SV=1 PF11808//PF03611//PF00621//PF02196//PF04898 Domain of unknown function (DUF3329)//PTS system sugar-specific permease component//RhoGEF domain//Raf-like Ras-binding domain//Glutamate synthase central domain GO:0016310//GO:0035023//GO:0006537//GO:0007165//GO:0006807//GO:0055114//GO:0043087//GO:0009401 phosphorylation//regulation of Rho protein signal transduction//glutamate biosynthetic process//signal transduction//nitrogen compound metabolic process//oxidation-reduction process//regulation of GTPase activity//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005057//GO:0005089//GO:0015930//GO:0004673 receptor signaling protein activity//Rho guanyl-nucleotide exchange factor activity//glutamate synthase activity//protein histidine kinase activity GO:0009365//GO:0016021 protein histidine kinase complex//integral component of membrane KOG3521 Predicted guanine nucleotide exchange factor Cluster-8309.15577 BP_3 4.00 0.75 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1558 BP_3 12.36 0.31 2218 478263113 ENN81506.1 210 6.4e-14 hypothetical protein YQE_02035, partial [Dendroctonus ponderosae]>gi|546675494|gb|ERL86679.1| hypothetical protein D910_04085, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P11734 144 1.2e-07 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15580 BP_3 221.00 9.97 1360 642921238 XP_008192777.1 884 2.8e-92 PREDICTED: rRNA-processing protein FCF1 homolog [Tribolium castaneum] 572304285 XM_006618048.1 202 3.10632e-99 PREDICTED: Apis dorsata rRNA-processing protein FCF1 homolog (LOC102672622), transcript variant X2, mRNA K14566 UTP24, FCF1 U3 small nucleolar RNA-associated protein 24 http://www.genome.jp/dbget-bin/www_bget?ko:K14566 Q32PD0 741 4.3e-77 rRNA-processing protein FCF1 homolog OS=Bos taurus GN=FCF1 PE=2 SV=1 PF04900 Fcf1 -- -- -- -- GO:0032040 small-subunit processome KOG3165 Predicted nucleic-acid-binding protein, contains PIN domain Cluster-8309.15584 BP_3 26.00 0.71 2055 91081495 XP_974508.1 1420 2.9e-154 PREDICTED: DNA-binding protein D-ETS-6 [Tribolium castaneum]>gi|270005143|gb|EFA01591.1| hypothetical protein TcasGA2_TC007154 [Tribolium castaneum] 488552843 XM_004467731.1 135 8.32676e-62 PREDICTED: Dasypus novemcinctus FEV (ETS oncogene family) (FEV), mRNA K09436 FLI1 friend leukemia integration 1 transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09436 P29776 762 2.4e-79 DNA-binding protein D-ETS-6 OS=Drosophila melanogaster GN=Ets21C PE=2 SV=2 PF00447//PF02198//PF00178//PF07571 HSF-type DNA-binding//Sterile alpha motif (SAM)/Pointed domain//Ets-domain//TAF6 C-terminal HEAT repeat domain GO:0051090//GO:0006355 regulation of sequence-specific DNA binding transcription factor activity//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3806 Predicted transcription factor Cluster-8309.15591 BP_3 231.00 4.38 2835 91093959 XP_968177.1 2398 1.6e-267 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270010930|gb|EFA07378.1| hypothetical protein TcasGA2_TC016355 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 1539 2.6e-169 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF04234//PF01266//PF05834//PF00732//PF07992 GMC oxidoreductase//CopC domain//FAD dependent oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0046688//GO:0055114//GO:0016117 response to copper ion//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0005507//GO:0016705//GO:0016614//GO:0050660 oxidoreductase activity//copper ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding GO:0042597 periplasmic space -- -- Cluster-8309.15598 BP_3 15.49 0.45 1967 91094277 XP_970700.1 884 4.0e-92 PREDICTED: arfaptin-2 [Tribolium castaneum]>gi|270014395|gb|EFA10843.1| hypothetical protein TcasGA2_TC001620 [Tribolium castaneum] 807015662 XM_004517862.2 49 5.1082e-14 PREDICTED: Ceratitis capitata arfaptin-2 (LOC101461303), transcript variant X3, mRNA -- -- -- -- P53365 632 2.7e-64 Arfaptin-2 OS=Homo sapiens GN=ARFIP2 PE=1 SV=1 PF06456 Arfaptin-like domain -- -- GO:0019904 protein domain specific binding -- -- KOG3651 Protein kinase C, alpha binding protein Cluster-8309.15599 BP_3 533.00 9.10 3115 675376395 KFM69297.1 146 2.4e-06 hypothetical protein X975_03065, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01020 Ribosomal L40e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.156 BP_3 15.00 0.99 1023 642917403 XP_008191182.1 560 7.7e-55 PREDICTED: tyrosine-protein phosphatase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15606 BP_3 122.92 4.48 1615 642921579 XP_008192431.1 1070 8.9e-114 PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum]>gi|642921581|ref|XP_008192432.1| PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum] 642921580 XM_008194210.1 260 2.1216e-131 PREDICTED: Tribolium castaneum MOB kinase activator-like 2 (LOC657020), transcript variant X2, mRNA -- -- -- -- Q2LZ59 929 8.2e-99 MOB kinase activator-like 2 OS=Drosophila pseudoobscura pseudoobscura GN=Mob1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.15609 BP_3 114.00 29.94 475 91087977 XP_973274.1 400 1.3e-36 PREDICTED: U6 snRNA-associated Sm-like protein LSm3 [Tribolium castaneum]>gi|270011905|gb|EFA08353.1| hypothetical protein TcasGA2_TC005996 [Tribolium castaneum] -- -- -- -- -- K12622 LSM3 U6 snRNA-associated Sm-like protein LSm3 http://www.genome.jp/dbget-bin/www_bget?ko:K12622 P62310 312 8.4e-28 U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens GN=LSM3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3460 Small nuclear ribonucleoprotein (snRNP) LSM3 Cluster-8309.1561 BP_3 22.00 1.23 1155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15611 BP_3 8.41 0.51 1091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15614 BP_3 1.00 4.30 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15616 BP_3 3.00 0.40 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15619 BP_3 6.00 0.90 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1562 BP_3 4332.62 50.96 4390 546683810 ERL93563.1 4261 0.0e+00 hypothetical protein D910_10852 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2569 1.5e-288 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00931//PF03969//PF02367//PF06414//PF01637//PF03193//PF00005//PF00004//PF00437//PF13304//PF01926//PF00664//PF08477 NB-ARC domain//AFG1-like ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase GO:0055085//GO:0006810//GO:0002949//GO:0007264 transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0005524//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626 ATP binding//ADP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.15626 BP_3 31.00 0.49 3335 242020354 XP_002430620.1 618 4.7e-61 leucine-rich repeat-containing protein, putative [Pediculus humanus corporis]>gi|212515792|gb|EEB17882.1| leucine-rich repeat-containing protein, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q5ZLN0 183 5.4e-12 Leucine-rich repeat-containing protein 40 OS=Gallus gallus GN=LRRC40 PE=2 SV=1 PF04815//PF00560//PF13855 Sec23/Sec24 helical domain//Leucine Rich Repeat//Leucine rich repeat GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0005515 protein binding GO:0030127 COPII vesicle coat KOG0619 FOG: Leucine rich repeat Cluster-8309.15629 BP_3 7.00 1.77 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1563 BP_3 9.00 0.64 974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00895 ATP synthase protein 8 GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.15631 BP_3 13.00 0.57 1382 91082081 XP_966726.1 429 1.6e-39 PREDICTED: uncharacterized protein LOC655123 [Tribolium castaneum]>gi|270007416|gb|EFA03864.1| hypothetical protein TcasGA2_TC013985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08465 Thymidine kinase from Herpesvirus C-terminal GO:0006206//GO:0006230 pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0005524//GO:0004797 ATP binding//thymidine kinase activity -- -- -- -- Cluster-8309.15632 BP_3 8.17 2.09 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15635 BP_3 23.00 1.54 1012 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15636 BP_3 110.92 2.41 2511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04083//PF00895 Partial alpha/beta-hydrolase lipase region//ATP synthase protein 8 GO:0015986//GO:0015992//GO:0006629 ATP synthesis coupled proton transport//proton transport//lipid metabolic process GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.15638 BP_3 112.85 11.05 784 642933343 XP_008197375.1 451 2.6e-42 PREDICTED: charged multivesicular body protein 6-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K12195 CHMP6, VPS20 charged multivesicular body protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12195 Q6GMA4 329 1.5e-29 Charged multivesicular body protein 6-A OS=Xenopus laevis GN=chmp6-a PE=2 SV=3 PF01063//PF03357//PF06112 Amino-transferase class IV//Snf7//Gammaherpesvirus capsid protein GO:0008152//GO:0007034 metabolic process//vacuolar transport GO:0003824 catalytic activity GO:0019028 viral capsid KOG2910 Uncharacterized conserved protein predicted to be involved in protein sorting Cluster-8309.15645 BP_3 1504.00 17.50 4433 642917187 XP_966629.2 4401 0.0e+00 PREDICTED: transient receptor potential channel pyrexia [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 1005 3.4e-107 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF13606//PF00023//PF00520//PF06005 Ankyrin repeat//Ankyrin repeat//Ion transport protein//Protein of unknown function (DUF904) GO:0000917//GO:0006811//GO:0043093//GO:0055085 barrier septum assembly//ion transport//FtsZ-dependent cytokinesis//transmembrane transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-8309.15649 BP_3 148.94 2.10 3714 91083357 XP_975102.1 2572 1.4e-287 PREDICTED: suppressor of hairless protein [Tribolium castaneum]>gi|270008236|gb|EFA04684.1| suppressor of hairless [Tribolium castaneum] 642923838 XM_970009.2 515 0 PREDICTED: Tribolium castaneum suppressor of hairless (LOC663984), mRNA K06053 RBPSUH, RBPJK recombining binding protein suppressor of hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06053 P28159 2150 4.9e-240 Suppressor of hairless protein OS=Drosophila melanogaster GN=Su(H) PE=1 SV=1 PF01833//PF09271//PF09270 IPT/TIG domain//LAG1, DNA binding//Beta-trefoil DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0000978//GO:0003700//GO:0000982//GO:0005515//GO:0003677 RNA polymerase II core promoter proximal region sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//protein binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3743 Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5) Cluster-8309.1565 BP_3 12.19 0.33 2057 572315890 XP_006623586.1 2032 3.2e-225 PREDICTED: ras-specific guanine nucleotide-releasing factor 2-like isoform X4 [Apis dorsata] 676423901 XM_009045908.1 171 8.10244e-82 Lottia gigantea hypothetical protein partial mRNA K04349 RASGRF1 Ras-specific guanine nucleotide-releasing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04349 A2CEA7 1491 7.1e-164 Ras-specific guanine nucleotide-releasing factor 2 OS=Danio rerio GN=rasgrf2 PE=3 SV=1 PF15182//PF00621//PF00612//PF06156//PF10473//PF05493//PF15898 Otospiralin//RhoGEF domain//IQ calmodulin-binding motif//Protein of unknown function (DUF972)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//ATP synthase subunit H//cGMP-dependent protein kinase interacting domain GO:0007605//GO:0035023//GO:0015992//GO:0006260//GO:0015991//GO:0043087 sensory perception of sound//regulation of Rho protein signal transduction//proton transport//DNA replication//ATP hydrolysis coupled proton transport//regulation of GTPase activity GO:0045502//GO:0008134//GO:0019901//GO:0015078//GO:0005515//GO:0005089//GO:0042803 dynein binding//transcription factor binding//protein kinase binding//hydrogen ion transmembrane transporter activity//protein binding//Rho guanyl-nucleotide exchange factor activity//protein homodimerization activity GO:0005667//GO:0030286//GO:0033179 transcription factor complex//dynein complex//proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.15651 BP_3 285.00 1.82 7826 642923170 XP_008193638.1 1098 2.4e-116 PREDICTED: uncharacterized protein LOC103313086 [Tribolium castaneum] 642923169 XM_008195416.1 353 0 PREDICTED: Tribolium castaneum uncharacterized LOC103313086 (LOC103313086), mRNA -- -- -- -- A2AWH2 159 7.6e-09 Transmembrane protein FAM155A OS=Danio rerio GN=fam155a PE=2 SV=1 PF01392 Fz domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15657 BP_3 305.17 3.69 4283 91078420 XP_974692.1 1424 2.1e-154 PREDICTED: tektin-3 [Tribolium castaneum]>gi|270003874|gb|EFA00322.1| hypothetical protein TcasGA2_TC003160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16T79 1220 3.9e-132 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Aedes aegypti GN=AAEL010360 PE=3 SV=2 PF16716//PF03082//PF02951//PF07728//PF03255//PF00931//PF06414//PF09177//PF10018//PF01544//PF01920//PF00437//PF16331//PF01583//PF08702//PF08912//PF03938//PF08653//PF07989//PF03193//PF00005 Bone marrow stromal antigen 2//Male accessory gland secretory protein//Prokaryotic glutathione synthetase, N-terminal domain//AAA domain (dynein-related subfamily)//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//NB-ARC domain//Zeta toxin//Syntaxin 6, N-terminal//Vitamin-D-receptor interacting Mediator subunit 4//CorA-like Mg2+ transporter protein//Prefoldin subunit//Type II/IV secretion system protein//TolA binding protein trimerisation//Adenylylsulphate kinase//Fibrinogen alpha/beta chain family//Rho Binding//Outer membrane protein (OmpH-like)//DASH complex subunit Dam1//Centrosomin N-terminal motif 1//Protein of unknown function, DUF258//ABC transporter GO:0030168//GO:0048193//GO:0000103//GO:0006633//GO:0006750//GO:0006357//GO:0008608//GO:0006090//GO:0055085//GO:0000226//GO:0007618//GO:0051607//GO:0006144//GO:0030001//GO:0006457//GO:0051258//GO:0006810//GO:0070206//GO:0007165 platelet activation//Golgi vesicle transport//sulfate assimilation//fatty acid biosynthetic process//glutathione biosynthetic process//regulation of transcription from RNA polymerase II promoter//attachment of spindle microtubules to kinetochore//pyruvate metabolic process//transmembrane transport//microtubule cytoskeleton organization//mating//defense response to virus//purine nucleobase metabolic process//metal ion transport//protein folding//protein polymerization//transport//protein trimerization//signal transduction GO:0003989//GO:0017048//GO:0030674//GO:0046873//GO:0001104//GO:0051082//GO:0016301//GO:0005102//GO:0016887//GO:0003924//GO:0005524//GO:0005525//GO:0043531//GO:0004020//GO:0004363 acetyl-CoA carboxylase activity//Rho GTPase binding//protein binding, bridging//metal ion transmembrane transporter activity//RNA polymerase II transcription cofactor activity//unfolded protein binding//kinase activity//receptor binding//ATPase activity//GTPase activity//ATP binding//GTP binding//ADP binding//adenylylsulfate kinase activity//glutathione synthase activity GO:0016592//GO:0072686//GO:0016272//GO:0005577//GO:0005576//GO:0016020//GO:0005874//GO:0009317//GO:0042729//GO:0005815 mediator complex//mitotic spindle//prefoldin complex//fibrinogen complex//extracellular region//membrane//microtubule//acetyl-CoA carboxylase complex//DASH complex//microtubule organizing center KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.15658 BP_3 2.00 3.23 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1566 BP_3 256.73 7.83 1872 270010965 EFA07413.1 1058 2.5e-112 serine protease P84 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 309 7.4e-27 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF02454//PF00089 Sigma 1s protein//Trypsin GO:0019048//GO:0006508 modulation by virus of host morphology or physiology//proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.15663 BP_3 143.03 2.37 3196 815765768 XP_012215589.1 186 5.6e-11 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q9D305 146 1.0e-07 THAP domain-containing protein 2 OS=Mus musculus GN=Thap2 PE=2 SV=1 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.15664 BP_3 6947.79 111.24 3302 642936789 XP_008198582.1 3433 0.0e+00 PREDICTED: peroxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VEG6 885 2.1e-93 Chorion peroxidase OS=Drosophila melanogaster GN=Pxt PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.15665 BP_3 11.64 0.33 2010 91088781 XP_976139.1 435 4.7e-40 PREDICTED: methylosome protein 50 [Tribolium castaneum]>gi|270011629|gb|EFA08077.1| hypothetical protein TcasGA2_TC005673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15668 BP_3 152.58 6.71 1387 91088781 XP_976139.1 805 4.1e-83 PREDICTED: methylosome protein 50 [Tribolium castaneum]>gi|270011629|gb|EFA08077.1| hypothetical protein TcasGA2_TC005673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54H44 136 6.3e-07 WD repeat domain-containing protein 83 homolog OS=Dictyostelium discoideum GN=morg1 PE=3 SV=1 PF06017//PF00400 Unconventional myosin tail, actin- and lipid-binding//WD domain, G-beta repeat -- -- GO:0003774//GO:0005515 motor activity//protein binding GO:0016459 myosin complex -- -- Cluster-8309.1567 BP_3 14.00 0.59 1444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15672 BP_3 56.32 0.68 4255 642919497 XP_008191896.1 2940 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15673 BP_3 13.38 3.28 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15676 BP_3 13.83 0.80 1130 641672407 XP_008185929.1 165 5.4e-09 PREDICTED: uncharacterized protein LOC103310210 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.1568 BP_3 109.81 2.67 2272 111120235 BAF02624.1 2239 3.5e-249 heat shock protein 70 [Theileria ovis] 697081291 XM_009655815.1 2047 0 Verticillium dahliae VdLs.17 hsp70-like protein partial mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q01233 2573 2.7e-289 Heat shock 70 kDa protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hsps-1 PE=2 SV=2 PF06723//PF02782//PF01791//PF01968 MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//DeoC/LacD family aldolase//Hydantoinase/oxoprolinase GO:0000902//GO:0005975 cell morphogenesis//carbohydrate metabolic process GO:0016773//GO:0016787//GO:0016829 phosphotransferase activity, alcohol group as acceptor//hydrolase activity//lyase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.15681 BP_3 11.55 0.72 1064 91084671 XP_966504.1 302 6.6e-25 PREDICTED: lambda-crystallin [Tribolium castaneum]>gi|270008625|gb|EFA05073.1| hypothetical protein TcasGA2_TC015170 [Tribolium castaneum] -- -- -- -- -- K13247 CRYL1 L-gulonate 3-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K13247 Q8SPX7 211 9.7e-16 Lambda-crystallin homolog OS=Bos taurus GN=CRYL1 PE=2 SV=3 PF02737//PF12592 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Protein of unknown function (DUF3763) GO:0006552//GO:0006554//GO:0055114//GO:0006568//GO:0006631//GO:0006550//GO:0006574//GO:0006633//GO:0018874 leucine catabolic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//fatty acid metabolic process//isoleucine catabolic process//valine catabolic process//fatty acid biosynthetic process//benzoate metabolic process GO:0003857//GO:0016820//GO:0016491//GO:0070403 3-hydroxyacyl-CoA dehydrogenase activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//oxidoreductase activity//NAD+ binding -- -- KOG2305 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.15682 BP_3 14.53 0.47 1767 91094849 XP_971994.1 1556 4.3e-170 PREDICTED: probable queuine tRNA-ribosyltransferase [Tribolium castaneum]>gi|270006549|gb|EFA02997.1| hypothetical protein TcasGA2_TC010418 [Tribolium castaneum] 801376774 XM_012208846.1 138 1.53455e-63 PREDICTED: Atta cephalotes probable queuine tRNA-ribosyltransferase (LOC105627565), mRNA K00773 tgt, QTRT1 queuine tRNA-ribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00773 Q9VPY8 1155 5.5e-125 Probable queuine tRNA-ribosyltransferase OS=Drosophila melanogaster GN=Tgt PE=2 SV=1 PF01702 Queuine tRNA-ribosyltransferase GO:0006400//GO:0008616 tRNA modification//queuosine biosynthetic process GO:0008479 queuine tRNA-ribosyltransferase activity -- -- KOG3908 Queuine-tRNA ribosyltransferase Cluster-8309.15683 BP_3 74.47 2.28 1864 91094849 XP_971994.1 1723 1.9e-189 PREDICTED: probable queuine tRNA-ribosyltransferase [Tribolium castaneum]>gi|270006549|gb|EFA02997.1| hypothetical protein TcasGA2_TC010418 [Tribolium castaneum] 801376774 XM_012208846.1 151 9.61584e-71 PREDICTED: Atta cephalotes probable queuine tRNA-ribosyltransferase (LOC105627565), mRNA K00773 tgt, QTRT1 queuine tRNA-ribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00773 Q9VPY8 1286 3.8e-140 Probable queuine tRNA-ribosyltransferase OS=Drosophila melanogaster GN=Tgt PE=2 SV=1 PF01702 Queuine tRNA-ribosyltransferase GO:0006400//GO:0008616 tRNA modification//queuosine biosynthetic process GO:0008479 queuine tRNA-ribosyltransferase activity -- -- KOG3908 Queuine-tRNA ribosyltransferase Cluster-8309.15684 BP_3 528.25 7.82 3548 332375705 AEE62993.1 1349 8.7e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01619 deoC, DERA deoxyribose-phosphate aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01619 Q9Y315 963 2.0e-102 Deoxyribose-phosphate aldolase OS=Homo sapiens GN=DERA PE=1 SV=2 PF00096//PF13465//PF01791//PF16622//PF00651 Zinc finger, C2H2 type//Zinc-finger double domain//DeoC/LacD family aldolase//zinc-finger C2H2-type//BTB/POZ domain -- -- GO:0046872//GO:0016829//GO:0005515 metal ion binding//lyase activity//protein binding -- -- KOG3981 Deoxyribose-phosphate aldolase Cluster-8309.15687 BP_3 5.00 0.31 1063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15688 BP_3 20.14 0.76 1568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1569 BP_3 16.19 0.38 2349 38683403 AAO38780.1 2031 4.7e-225 heat shock protein 70 [Azumapecten farreri] 697081291 XM_009655815.1 1519 0 Verticillium dahliae VdLs.17 hsp70-like protein partial mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q01233 2313 3.9e-259 Heat shock 70 kDa protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hsps-1 PE=2 SV=2 PF06723//PF02782//PF01968 MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//Hydantoinase/oxoprolinase GO:0000902//GO:0005975 cell morphogenesis//carbohydrate metabolic process GO:0016787//GO:0016773 hydrolase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.15692 BP_3 3.25 5.61 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15697 BP_3 12.71 0.38 1924 642918606 XP_008200307.1 502 7.7e-48 PREDICTED: uncharacterized protein LOC103314890 isoform X1 [Tribolium castaneum]>gi|642918608|ref|XP_008200313.1| PREDICTED: uncharacterized protein LOC103314890 isoform X2 [Tribolium castaneum]>gi|270004660|gb|EFA01108.1| hypothetical protein TcasGA2_TC004033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1570 BP_3 11.00 0.78 975 642916432 XP_008191024.1 616 2.4e-61 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15702 BP_3 13.42 0.70 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15708 BP_3 22.00 0.57 2168 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15713 BP_3 75.83 2.74 1624 166998659 NP_001107798.1 498 1.9e-47 Snipper [Tribolium castaneum]>gi|156447793|gb|ABU63675.1| Snipper [Tribolium castaneum] -- -- -- -- -- K18417 ERI2 ERI1 exoribonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18417 Q5HZL1 391 2.0e-36 ERI1 exoribonuclease 2 OS=Xenopus laevis GN=eri2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0542 Predicted exonuclease Cluster-8309.15714 BP_3 147.58 2.95 2704 91077680 XP_974637.1 1934 9.7e-214 PREDICTED: pre-mRNA-splicing factor Slu7 [Tribolium castaneum]>gi|270001533|gb|EEZ97980.1| hypothetical protein TcasGA2_TC000375 [Tribolium castaneum] 762095952 XM_011432193.1 51 5.45151e-15 PREDICTED: Crassostrea gigas pre-mRNA-splicing factor SLU7-like (LOC105330483), transcript variant X2, mRNA K12819 SLU7 pre-mRNA-processing factor SLU7 http://www.genome.jp/dbget-bin/www_bget?ko:K12819 Q9VAQ7 1403 1.5e-153 Pre-mRNA-splicing factor Slu7 OS=Drosophila melanogaster GN=Slu7 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2560 RNA splicing factor - Slu7p Cluster-8309.15715 BP_3 254.49 4.84 2825 91077680 XP_974637.1 1934 1.0e-213 PREDICTED: pre-mRNA-splicing factor Slu7 [Tribolium castaneum]>gi|270001533|gb|EEZ97980.1| hypothetical protein TcasGA2_TC000375 [Tribolium castaneum] 762095952 XM_011432193.1 51 5.69875e-15 PREDICTED: Crassostrea gigas pre-mRNA-splicing factor SLU7-like (LOC105330483), transcript variant X2, mRNA K12819 SLU7 pre-mRNA-processing factor SLU7 http://www.genome.jp/dbget-bin/www_bget?ko:K12819 Q9VAQ7 1403 1.6e-153 Pre-mRNA-splicing factor Slu7 OS=Drosophila melanogaster GN=Slu7 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2560 RNA splicing factor - Slu7p Cluster-8309.15716 BP_3 289.19 2.24 6528 478261817 ENN80940.1 1262 2.0e-135 hypothetical protein YQE_02645, partial [Dendroctonus ponderosae]>gi|546673708|gb|ERL85267.1| hypothetical protein D910_02688 [Dendroctonus ponderosae] -- -- -- -- -- K05610 UCHL5, UCH37 ubiquitin carboxyl-terminal hydrolase L5 http://www.genome.jp/dbget-bin/www_bget?ko:K05610 Q9XSJ0 1055 8.1e-113 Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Bos taurus GN=UCHL5 PE=2 SV=1 PF00397//PF02845//PF00325//PF01088 WW domain//CUE domain//Bacterial regulatory proteins, crp family//Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006355//GO:0006511//GO:0006508//GO:0016579 regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process//proteolysis//protein deubiquitination GO:0004843//GO:0003677//GO:0005515 ubiquitin-specific protease activity//DNA binding//protein binding GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.15718 BP_3 29.57 0.37 4179 91082041 XP_970854.1 1810 3.6e-199 PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|642921977|ref|XP_008192967.1| PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|270007300|gb|EFA03748.1| hypothetical protein TcasGA2_TC013857 [Tribolium castaneum] -- -- -- -- -- K10519 ZBTB48, HKR3 zinc finger and BTB domain-containing protein 48 http://www.genome.jp/dbget-bin/www_bget?ko:K10519 Q5R4K8 177 3.3e-11 Zinc finger protein 615 OS=Pongo abelii GN=ZNF615 PE=2 SV=2 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- -- -- Cluster-8309.15719 BP_3 68.11 0.69 5018 91082041 XP_970854.1 1810 4.3e-199 PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|642921977|ref|XP_008192967.1| PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|270007300|gb|EFA03748.1| hypothetical protein TcasGA2_TC013857 [Tribolium castaneum] -- -- -- -- -- K10519 ZBTB48, HKR3 zinc finger and BTB domain-containing protein 48 http://www.genome.jp/dbget-bin/www_bget?ko:K10519 Q5R4K8 177 4.0e-11 Zinc finger protein 615 OS=Pongo abelii GN=ZNF615 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.15729 BP_3 14.84 0.83 1152 189239721 XP_967180.2 308 1.4e-25 PREDICTED: GATA zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270010752|gb|EFA07200.1| hypothetical protein TcasGA2_TC010207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUU5 197 4.4e-14 GATA zinc finger domain-containing protein 1 OS=Homo sapiens GN=GATAD1 PE=1 SV=1 PF04921//PF00320//PF01412 XAP5, circadian clock regulator//GATA zinc finger//Putative GTPase activating protein for Arf GO:0006355 regulation of transcription, DNA-templated GO:0005096//GO:0043565//GO:0008270//GO:0003700 GTPase activator activity//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.15730 BP_3 70.00 4.49 1043 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15732 BP_3 20.11 0.69 1689 91080649 XP_974556.1 705 2.0e-71 PREDICTED: E3 ubiquitin-protein ligase TRIM9 [Tribolium castaneum]>gi|270005500|gb|EFA01948.1| hypothetical protein TcasGA2_TC007563 [Tribolium castaneum] -- -- -- -- -- K10649 TRIM9_67 tripartite motif-containing protein 9/67 http://www.genome.jp/dbget-bin/www_bget?ko:K10649 Q29RQ5 316 1.0e-27 E3 ubiquitin-protein ligase TRIM9 OS=Bos taurus GN=TRIM9 PE=2 SV=1 PF01442//PF05130//PF02601//PF05823//PF09280 Apolipoprotein A1/A4/E domain//FlgN protein//Exonuclease VII, large subunit//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//XPC-binding domain GO:0043161//GO:0006289//GO:0006308//GO:0006281//GO:0006869//GO:0042157//GO:0044780 proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair//DNA catabolic process//DNA repair//lipid transport//lipoprotein metabolic process//bacterial-type flagellum assembly GO:0046872//GO:0003684//GO:0008270//GO:0008855//GO:0008289 metal ion binding//damaged DNA binding//zinc ion binding//exodeoxyribonuclease VII activity//lipid binding GO:0005622//GO:0005576//GO:0009318 intracellular//extracellular region//exodeoxyribonuclease VII complex KOG4367 Predicted Zn-finger protein Cluster-8309.15735 BP_3 713.60 13.24 2889 642921918 XP_008192944.1 2013 7.1e-223 PREDICTED: zinc finger MYND domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15326 593 1.3e-59 Zinc finger MYND domain-containing protein 11 OS=Homo sapiens GN=ZMYND11 PE=1 SV=2 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.15738 BP_3 30.45 0.85 2028 642919283 XP_008191808.1 561 1.2e-54 PREDICTED: leucine-rich repeat protein soc-2 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VJ07 185 1.9e-12 Protein phosphatase PHLPP-like protein OS=Drosophila melanogaster GN=Phlpp PE=3 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.15740 BP_3 331.00 25.43 919 91079510 XP_969537.1 904 8.9e-95 PREDICTED: methyl-CpG-binding domain protein 2 [Tribolium castaneum]>gi|270004424|gb|EFA00872.1| hypothetical protein TcasGA2_TC003775 [Tribolium castaneum] -- -- -- -- -- K11590 MBD2 methyl-CpG-binding domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11590 Q9UBB5 363 2.0e-33 Methyl-CpG-binding domain protein 2 OS=Homo sapiens GN=MBD2 PE=1 SV=1 PF01429 Methyl-CpG binding domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.15743 BP_3 13.33 0.87 1032 478258940 ENN78915.1 334 1.2e-28 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 P19881 180 3.7e-12 4-nitrophenylphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO13 PE=1 SV=2 PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.15744 BP_3 33.63 0.43 4089 642937864 XP_008200330.1 2797 0.0e+00 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEP1 1735 7.1e-192 Protein FAM91A1 OS=Danio rerio GN=fam91a1 PE=2 SV=2 PF03480 Bacterial extracellular solute-binding protein, family 7 GO:0006810 transport -- -- GO:0030288 outer membrane-bounded periplasmic space KOG3707 Uncharacterized conserved protein Cluster-8309.15745 BP_3 65.35 2.24 1699 91084215 XP_968530.1 1374 5.2e-149 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZAI5 784 5.6e-82 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF08471//PF03015//PF01370//PF03435//PF01118//PF01073 Class II vitamin B12-dependent ribonucleotide reductase//Male sterility protein//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0006206//GO:0006144//GO:0009186//GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process//estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0004748//GO:0051287//GO:0016491//GO:0003824//GO:0050897//GO:0016620//GO:0080019//GO:0016616//GO:0003854//GO:0050662 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//NAD binding//oxidoreductase activity//catalytic activity//cobalt ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-8309.15746 BP_3 48.27 1.00 2625 270004041 EFA00489.1 2621 2.0e-293 hypothetical protein TcasGA2_TC003349 [Tribolium castaneum] 642915621 XM_008192489.1 428 0 PREDICTED: Tribolium castaneum protein tramtrack, beta isoform (LOC660343), transcript variant X3, mRNA -- -- -- -- Q9W0K7 396 8.5e-37 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF05007//PF02796//PF05225//PF00651 Mannosyltransferase (PIG-M)//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//BTB/POZ domain GO:0006506//GO:0006310 GPI anchor biosynthetic process//DNA recombination GO:0003677//GO:0016758//GO:0005515//GO:0000150 DNA binding//transferase activity, transferring hexosyl groups//protein binding//recombinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.15748 BP_3 4.00 0.46 707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15750 BP_3 2.00 0.38 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15753 BP_3 116.00 12.87 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15754 BP_3 254.98 13.80 1182 91078470 XP_968039.1 829 5.7e-86 PREDICTED: uncharacterized protein C16orf52 homolog A [Tribolium castaneum]>gi|270004014|gb|EFA00462.1| hypothetical protein TcasGA2_TC003319 [Tribolium castaneum] 766933212 XM_011500562.1 148 2.80561e-69 PREDICTED: Ceratosolen solmsi marchali uncharacterized protein C16orf52 homolog A (LOC105362993), transcript variant X2, mRNA K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q6GR34 493 2.1e-48 Uncharacterized protein C16orf52 homolog A OS=Xenopus laevis PE=2 SV=1 PF01006//PF01654 Hepatitis C virus non-structural protein NS4a//Cytochrome bd terminal oxidase subunit I GO:0016032 viral process -- -- GO:0016020//GO:0019012 membrane//virion -- -- Cluster-8309.15757 BP_3 4.00 15.24 272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1576 BP_3 9.00 0.47 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15760 BP_3 71.56 5.86 880 642912076 XP_008200791.1 562 3.9e-55 PREDICTED: U7 snRNA-associated Sm-like protein LSm11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T076 195 5.8e-14 U7 snRNA-associated Sm-like protein LSm11 OS=Xenopus laevis GN=lsm11 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15762 BP_3 4195.68 108.65 2153 270002502 EEZ98949.1 1256 3.2e-135 hypothetical protein TcasGA2_TC004573 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 717 4.2e-74 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.15764 BP_3 30.00 4.33 626 91089671 XP_974390.1 344 5.2e-30 PREDICTED: protein lethal(2)essential for life [Tribolium castaneum]>gi|270012628|gb|EFA09076.1| hypothetical protein TcasGA2_TC006793 [Tribolium castaneum] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 174 1.1e-11 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525 Alpha crystallin A chain, N terminal GO:0007423 sensory organ development GO:0005212 structural constituent of eye lens -- -- -- -- Cluster-8309.15765 BP_3 25.19 2.56 766 332377007 AEE63643.1 212 1.3e-14 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P02515 130 1.7e-06 Heat shock protein 22 OS=Drosophila melanogaster GN=Hsp22 PE=1 SV=4 PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.15766 BP_3 18.81 2.38 672 332377007 AEE63643.1 212 1.1e-14 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P02515 130 1.5e-06 Heat shock protein 22 OS=Drosophila melanogaster GN=Hsp22 PE=1 SV=4 PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.1577 BP_3 2.00 0.77 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15774 BP_3 23.00 2.31 771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15775 BP_3 9.00 2.00 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15776 BP_3 290.00 42.06 624 478256344 ENN76534.1 592 9.2e-59 hypothetical protein YQE_06985, partial [Dendroctonus ponderosae]>gi|546680774|gb|ERL90980.1| hypothetical protein D910_08322 [Dendroctonus ponderosae] -- -- -- -- -- K15171 SUPT4H1, SPT4 transcription elongation factor SPT4 http://www.genome.jp/dbget-bin/www_bget?ko:K15171 Q9TVQ5 480 3.7e-47 Transcription elongation factor SPT4 OS=Drosophila melanogaster GN=spt4 PE=1 SV=1 PF00105 Zinc finger, C4 type (two domains) GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3490 Transcription elongation factor SPT4 Cluster-8309.15778 BP_3 38.13 0.33 5909 642918582 XP_008199358.1 1142 1.5e-121 PREDICTED: E3 ubiquitin-protein ligase LRSAM1-like [Tribolium castaneum] -- -- -- -- -- K10641 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 http://www.genome.jp/dbget-bin/www_bget?ko:K10641 Q6UWE0 355 1.1e-31 E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens GN=LRSAM1 PE=1 SV=1 PF13516//PF13855//PF00560 Leucine Rich repeat//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.1578 BP_3 6.00 0.33 1180 260800652 XP_002595212.1 1177 2.5e-126 hypothetical protein BRAFLDRAFT_238703 [Branchiostoma floridae]>gi|229280456|gb|EEN51224.1| hypothetical protein BRAFLDRAFT_238703 [Branchiostoma floridae] 768311752 CP010980.1 937 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 A1CJT5 1350 9.1e-148 ATP-dependent RNA helicase eIF4A OS=Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) GN=tif1 PE=3 SV=1 PF00270//PF00392//PF00579 DEAD/DEAH box helicase//Bacterial regulatory proteins, gntR family//tRNA synthetases class I (W and Y) GO:0006418//GO:0006355 tRNA aminoacylation for protein translation//regulation of transcription, DNA-templated GO:0003700//GO:0004812//GO:0003676//GO:0000166//GO:0008026//GO:0005524 transcription factor activity, sequence-specific DNA binding//aminoacyl-tRNA ligase activity//nucleic acid binding//nucleotide binding//ATP-dependent helicase activity//ATP binding GO:0005667 transcription factor complex KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily Cluster-8309.15784 BP_3 15.00 0.36 2315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15787 BP_3 99.53 1.28 4054 190702373 ACE75266.1 762 1.2e-77 conserved hypothetical protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07817//PF13545//PF02796//PF08398//PF01498//PF12833//PF01418//PF04566//PF13404 GLE1-like protein//Crp-like helix-turn-helix domain//Helix-turn-helix domain of resolvase//Parvovirus coat protein VP1//Transposase//Helix-turn-helix domain//Helix-turn-helix domain, rpiR family//RNA polymerase Rpb2, domain 4//AsnC-type helix-turn-helix domain GO:0006206//GO:0006310//GO:0015074//GO:0006351//GO:0006313//GO:0006144//GO:0006355//GO:0016973 pyrimidine nucleobase metabolic process//DNA recombination//DNA integration//transcription, DNA-templated//transposition, DNA-mediated//purine nucleobase metabolic process//regulation of transcription, DNA-templated//poly(A)+ mRNA export from nucleus GO:0003677//GO:0043565//GO:0003700//GO:0003899//GO:0005198//GO:0000150 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA-directed RNA polymerase activity//structural molecule activity//recombinase activity GO:0005667//GO:0005643//GO:0005730//GO:0019028 transcription factor complex//nuclear pore//nucleolus//viral capsid -- -- Cluster-8309.1579 BP_3 4.00 0.89 508 665789493 XP_008560387.1 407 2.1e-37 PREDICTED: eukaryotic initiation factor 4A-I-like [Microplitis demolitor] 697067690 XM_009650735.1 505 0 Verticillium dahliae VdLs.17 ATP-dependent RNA helicase eIF4A partial mRNA K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 Q2HFP1 453 4.0e-44 ATP-dependent RNA helicase eIF4A OS=Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) GN=TIF1 PE=3 SV=1 PF06446//PF07652//PF00270//PF02148//PF04851//PF00580 Hepcidin//Flavivirus DEAD domain//DEAD/DEAH box helicase//Zn-finger in ubiquitin-hydrolases and other protein//Type III restriction enzyme, res subunit//UvrD/REP helicase N-terminal domain GO:0006879//GO:0019079 cellular iron ion homeostasis//viral genome replication GO:0003677//GO:0016787//GO:0005524//GO:0008026//GO:0003676//GO:0008270 DNA binding//hydrolase activity//ATP binding//ATP-dependent helicase activity//nucleic acid binding//zinc ion binding GO:0005576 extracellular region KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.15794 BP_3 42.87 0.85 2719 91083991 XP_975229.1 1974 2.2e-218 PREDICTED: origin recognition complex subunit 3 [Tribolium castaneum]>gi|270006709|gb|EFA03157.1| hypothetical protein TcasGA2_TC013076 [Tribolium castaneum] -- -- -- -- -- K02605 ORC3 origin recognition complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02605 Q9UBD5 982 9.8e-105 Origin recognition complex subunit 3 OS=Homo sapiens GN=ORC3 PE=1 SV=1 PF07034//PF07531//PF04421 Origin recognition complex (ORC) subunit 3 N-terminus//NHR1 homology to TAF//Mss4 protein GO:0006355//GO:0006260//GO:0043087//GO:0007264 regulation of transcription, DNA-templated//DNA replication//regulation of GTPase activity//small GTPase mediated signal transduction GO:0003700//GO:0005085//GO:0003677 transcription factor activity, sequence-specific DNA binding//guanyl-nucleotide exchange factor activity//DNA binding GO:0005667//GO:0005664 transcription factor complex//nuclear origin of replication recognition complex KOG2538 Origin recognition complex, subunit 3 Cluster-8309.15795 BP_3 124.00 9.32 933 91089041 XP_969722.1 348 2.7e-30 PREDICTED: EKC/KEOPS complex subunit Tprkb [Tribolium castaneum]>gi|270012398|gb|EFA08846.1| hypothetical protein TcasGA2_TC006547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y3C4 219 1.0e-16 EKC/KEOPS complex subunit TPRKB OS=Homo sapiens GN=TPRKB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15799 BP_3 24.00 1.20 1257 91095011 XP_969955.1 755 2.3e-77 PREDICTED: transcription initiation factor TFIID subunit 9 [Tribolium castaneum]>gi|270015430|gb|EFA11878.1| hypothetical protein TcasGA2_TC004292 [Tribolium castaneum] -- -- -- -- -- K03133 TAF9B, TAF9 transcription initiation factor TFIID subunit 9B http://www.genome.jp/dbget-bin/www_bget?ko:K03133 Q27272 425 1.8e-40 Transcription initiation factor TFIID subunit 9 OS=Drosophila melanogaster GN=e(y)1 PE=1 SV=1 PF02291 Transcription initiation factor IID, 31kD subunit GO:0006352 DNA-templated transcription, initiation -- -- -- -- KOG3334 Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) Cluster-8309.1580 BP_3 24.00 1.65 991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15800 BP_3 15.00 0.73 1277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00522 VPR/VPX protein GO:0019058 viral life cycle -- -- GO:0042025 host cell nucleus -- -- Cluster-8309.15807 BP_3 520.41 4.69 5636 642913872 XP_008201198.1 1400 1.7e-151 PREDICTED: SH3 domain-containing kinase-binding protein 1 isoform X2 [Tribolium castaneum] 23589286 AK116679.1 38 1.92832e-07 Ciona intestinalis cDNA, clone:cieg003e24, full insert sequence K12470 SH3KBP1, CIN85 SH3 domain-containing kinase-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12470 Q925Q9 306 5.0e-26 SH3 domain-containing kinase-binding protein 1 OS=Rattus norvegicus GN=Sh3kbp1 PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4348 Adaptor protein CMS/SETA Cluster-8309.15810 BP_3 50.38 0.66 3964 91094031 XP_967783.1 1988 7.7e-220 PREDICTED: protein germ cell-less [Tribolium castaneum]>gi|270004797|gb|EFA01245.1| germ cell-less [Tribolium castaneum] -- -- -- -- -- K10485 BTBD13, GMCL1, GCL BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1) http://www.genome.jp/dbget-bin/www_bget?ko:K10485 Q01820 1009 1.1e-107 Protein germ cell-less OS=Drosophila melanogaster GN=gcl PE=2 SV=1 PF00651//PF02096 BTB/POZ domain//60Kd inner membrane protein GO:0051205 protein insertion into membrane GO:0005515 protein binding GO:0016021 integral component of membrane KOG1239 Inner membrane protein translocase involved in respiratory chain assembly Cluster-8309.15811 BP_3 32.72 1.86 1138 642923877 XP_008193910.1 516 1.1e-49 PREDICTED: aristaless isoform X1 [Tribolium castaneum] 543718138 XM_005500258.1 59 8.06115e-20 PREDICTED: Columba livia ALX homeobox 4 (ALX4), mRNA K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 Q06453 405 3.3e-38 Homeobox protein aristaless OS=Drosophila melanogaster GN=al PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.15812 BP_3 16.12 0.68 1438 91082063 XP_972067.1 574 2.6e-56 PREDICTED: glucose-induced degradation protein 8 homolog [Tribolium castaneum]>gi|270007278|gb|EFA03726.1| hypothetical protein TcasGA2_TC013835 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PC55 374 1.6e-34 Glucose-induced degradation protein 8 homolog OS=Danio rerio GN=gid8 PE=2 SV=1 PF08513 LisH -- -- GO:0005515 protein binding -- -- KOG2659 LisH motif-containing protein Cluster-8309.15813 BP_3 401.88 26.34 1027 91082063 XP_972067.1 1036 4.9e-110 PREDICTED: glucose-induced degradation protein 8 homolog [Tribolium castaneum]>gi|270007278|gb|EFA03726.1| hypothetical protein TcasGA2_TC013835 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKQ7 731 4.7e-76 Glucose-induced degradation protein 8 homolog OS=Gallus gallus GN=GID8 PE=2 SV=1 PF08513//PF01191 LisH//RNA polymerase Rpb5, C-terminal domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005730 nucleolus KOG2659 LisH motif-containing protein Cluster-8309.15814 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15819 BP_3 3.90 0.35 824 546677797 ERL88564.1 378 7.9e-34 hypothetical protein D910_05949, partial [Dendroctonus ponderosae] -- -- -- -- -- K06662 HRAD17, RAD24 cell cycle checkpoint protein http://www.genome.jp/dbget-bin/www_bget?ko:K06662 Q9XT62 199 1.8e-14 Cell cycle checkpoint protein RAD17 OS=Chlorocebus aethiops GN=RAD17 PE=1 SV=1 PF00448//PF00004//PF00437//PF05496//PF07728//PF01580//PF00910//PF04851//PF06414//PF02367//PF01637//PF03193//PF00005 SRP54-type protein, GTPase domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//FtsK/SpoIIIE family//RNA helicase//Type III restriction enzyme, res subunit//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter GO:0006614//GO:0006810//GO:0006281//GO:0002949//GO:0006310 SRP-dependent cotranslational protein targeting to membrane//transport//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination GO:0005524//GO:0016787//GO:0003924//GO:0000166//GO:0016301//GO:0016887//GO:0003723//GO:0003677//GO:0005525//GO:0009378//GO:0003724 ATP binding//hydrolase activity//GTPase activity//nucleotide binding//kinase activity//ATPase activity//RNA binding//DNA binding//GTP binding//four-way junction helicase activity//RNA helicase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component Cluster-8309.1582 BP_3 118.59 5.16 1399 91087331 XP_975597.1 780 3.3e-80 PREDICTED: TM2 domain-containing protein CG10795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W2H1 643 1.0e-65 TM2 domain-containing protein CG10795 OS=Drosophila melanogaster GN=CG10795 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4272 Predicted GTP-binding protein Cluster-8309.15820 BP_3 23.00 2.35 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15826 BP_3 6.36 0.49 915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15829 BP_3 295.69 5.10 3085 546679741 ERL90152.1 1446 4.3e-157 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BKN5 456 1.1e-43 Gamma-tubulin complex component 5 OS=Mus musculus GN=Tubgcp5 PE=2 SV=2 PF04505//PF04130 Interferon-induced transmembrane protein//Spc97 / Spc98 family GO:0009607//GO:0090063//GO:0000226 response to biotic stimulus//positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0016021//GO:0005815//GO:0000922 integral component of membrane//microtubule organizing center//spindle pole -- -- Cluster-8309.15830 BP_3 7.00 0.44 1067 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15831 BP_3 57.16 1.08 2851 642914172 XP_008201574.1 1953 6.4e-216 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 958 6.2e-102 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF01738 Dienelactone hydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.15833 BP_3 2.00 0.38 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15836 BP_3 19.00 0.52 2037 21622583 CAD13268.2 1015 2.7e-107 cytochrome oxidase subunit III [Manis tetradactyla] 545758161 KF161635.1 2037 0 Homo sapiens isolate 124224 mitochondrion, complete genome K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 P00414 1011 3.2e-108 Cytochrome c oxidase subunit 3 OS=Homo sapiens GN=MT-CO3 PE=1 SV=2 PF00119//PF00895//PF04834 ATP synthase A chain//ATP synthase protein 8//Early E3 14.5 kDa protein GO:0009966//GO:0015986//GO:0015992 regulation of signal transduction//ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276//GO:0016021 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-8309.15838 BP_3 1.00 0.61 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15843 BP_3 26.79 0.60 2451 478260276 ENN80028.1 271 6.0e-21 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2EI20 183 3.9e-12 RE1-silencing transcription factor OS=Danio rerio GN=rest PE=2 SV=1 PF06309//PF00096//PF13465//PF02150//PF07649 Torsin//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005524//GO:0046872//GO:0047134 DNA binding//DNA-directed RNA polymerase activity//ATP binding//metal ion binding//protein-disulfide reductase activity GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.15846 BP_3 23.02 0.37 3328 91094587 XP_970350.1 1679 4.4e-184 PREDICTED: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [Tribolium castaneum] 642939259 XM_965257.2 393 0 PREDICTED: Tribolium castaneum high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (LOC658906), mRNA K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 O70628 613 7.4e-62 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Mus musculus GN=Pde9a PE=1 SV=1 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.15847 BP_3 11.26 1.09 792 260804985 XP_002597368.1 245 2.0e-18 hypothetical protein BRAFLDRAFT_66503 [Branchiostoma floridae]>gi|229282631|gb|EEN53380.1| hypothetical protein BRAFLDRAFT_66503 [Branchiostoma floridae] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 221 5.0e-17 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF01679 Proteolipid membrane potential modulator -- -- -- -- GO:0016021 integral component of membrane KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.15848 BP_3 37.60 2.18 1124 646719797 KDR21783.1 608 2.3e-60 Protein SET [Zootermopsis nevadensis] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 559 4.5e-56 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF00956//PF03938//PF07352//PF05384//PF02990 Nucleosome assembly protein (NAP)//Outer membrane protein (OmpH-like)//Bacteriophage Mu Gam like protein//Sensor protein DegS//Endomembrane protein 70 GO:0007165//GO:0042262//GO:0006334 signal transduction//DNA protection//nucleosome assembly GO:0051082//GO:0016301//GO:0003690 unfolded protein binding//kinase activity//double-stranded DNA binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.15868 BP_3 67.83 1.54 2414 270013391 EFA09839.1 2883 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 462302184 APGK01050321.1 89 3.65408e-36 Dendroctonus ponderosae Seq01050331, whole genome shotgun sequence -- -- -- -- P21783 358 2.0e-32 Neurogenic locus notch homolog protein 1 OS=Xenopus laevis GN=notch1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.15869 BP_3 16.06 1.62 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1587 BP_3 14.00 0.33 2310 645026360 XP_008212069.1 997 3.7e-105 PREDICTED: uncharacterized protein LOC100680303 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF07881 DDE superfamily endonuclease//L-fucose isomerase, first N-terminal domain GO:0006004//GO:0006013//GO:0006000 fucose metabolic process//mannose metabolic process//fructose metabolic process GO:0008736//GO:0003676 L-fucose isomerase activity//nucleic acid binding GO:0005737 cytoplasm -- -- Cluster-8309.15870 BP_3 23.00 2.15 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15876 BP_3 3.00 0.45 614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15877 BP_3 1814.81 22.69 4146 642912669 XP_008200957.1 3277 0.0e+00 PREDICTED: aminopeptidase N [Tribolium castaneum] 556957556 XM_005989784.1 42 8.45756e-10 PREDICTED: Latimeria chalumnae alanyl (membrane) aminopeptidase (ANPEP), transcript variant X3, mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1579 8.9e-174 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.15879 BP_3 62.06 0.76 4228 478253041 ENN73421.1 1239 5.9e-133 hypothetical protein YQE_09983, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15880 BP_3 152.67 1.91 4152 478253041 ENN73421.1 2062 2.1e-228 hypothetical protein YQE_09983, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08651 DASH complex subunit Duo1 GO:0007067 mitotic nuclear division -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.15881 BP_3 34.42 0.65 2864 270004161 EFA00609.1 1556 6.9e-170 hypothetical protein TcasGA2_TC003484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08651 DASH complex subunit Duo1 GO:0007067 mitotic nuclear division -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.15886 BP_3 3.00 2.89 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15889 BP_3 19.00 0.35 2899 768418510 XP_011549944.1 1973 3.1e-218 PREDICTED: uncharacterized protein LOC105381841 [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q7LHG5 938 1.3e-99 Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-I PE=3 SV=2 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.15891 BP_3 10.00 0.90 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15894 BP_3 35.62 0.64 2969 -- -- -- -- -- 462321432 APGK01043255.1 58 7.69776e-19 Dendroctonus ponderosae Seq01043265, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15898 BP_3 57.27 2.08 1619 546679463 ERL89927.1 698 1.2e-70 hypothetical protein D910_07286 [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 O95425 451 2.2e-43 Supervillin OS=Homo sapiens GN=SVIL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15899 BP_3 33.00 1.26 1559 91087949 XP_972541.1 906 8.9e-95 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 A2AGA4 406 3.5e-38 Rhomboid-related protein 2 OS=Mus musculus GN=Rhbdl2 PE=1 SV=1 PF01694//PF13202//PF13405//PF13833//PF00036//PF13499 Rhomboid family//EF hand//EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509//GO:0004252 calcium ion binding//serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.159 BP_3 3.00 0.70 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15901 BP_3 12.00 0.89 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15903 BP_3 190.00 5.40 1989 635037386 XP_007994139.1 383 5.0e-34 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 737-like [Chlorocebus sabaeus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q68DY1 375 1.7e-34 Zinc finger protein 626 OS=Homo sapiens GN=ZNF626 PE=2 SV=2 PF07776//PF16622//PF13912//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.15907 BP_3 32.08 0.64 2689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00616 GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity -- -- -- -- -- -- Cluster-8309.15914 BP_3 413.21 9.40 2410 332376993 AEE63636.1 2320 1.5e-258 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14304 NUP85 nuclear pore complex protein Nup85 http://www.genome.jp/dbget-bin/www_bget?ko:K14304 Q8R480 1036 4.8e-111 Nuclear pore complex protein Nup85 OS=Mus musculus GN=Nup85 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15916 BP_3 531.74 5.17 5252 642929943 XP_008196036.1 680 4.8e-68 PREDICTED: microtubule-associated protein futsch-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q767L8 268 1.2e-21 Mediator of DNA damage checkpoint protein 1 OS=Sus scrofa GN=MDC1 PE=3 SV=1 PF01734//PF00498 Patatin-like phospholipase//FHA domain GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.15917 BP_3 2.00 0.39 541 642915122 XP_008190418.1 165 2.6e-09 PREDICTED: uncharacterized protein LOC103312186 [Tribolium castaneum]>gi|270002873|gb|EEZ99320.1| bifocal [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15918 BP_3 3.00 0.38 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04584 Poxvirus A28 family GO:0016032 viral process -- -- GO:0019031 viral envelope -- -- Cluster-8309.15920 BP_3 301.28 9.62 1802 91090546 XP_971052.1 992 1.1e-104 PREDICTED: tumor protein p63-regulated gene 1-like protein isoform X1 [Tribolium castaneum]>gi|270013883|gb|EFA10331.1| hypothetical protein TcasGA2_TC012549 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0D9 280 1.6e-23 Tumor protein p63-regulated gene 1-like protein OS=Homo sapiens GN=TPRG1L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15921 BP_3 4.00 0.38 801 642924676 XP_008194392.1 202 2.0e-13 PREDICTED: voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [Tribolium castaneum] 642924675 XM_008196170.1 161 1.11362e-76 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15922 BP_3 10.86 0.51 1319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15926 BP_3 15.00 1.89 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1593 BP_3 55.00 2.55 1331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15930 BP_3 95.10 2.67 2008 642937984 XP_008199157.1 282 2.6e-22 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15938 BP_3 42.18 0.91 2534 768440289 XP_011561812.1 823 6.1e-85 PREDICTED: uncharacterized protein LOC105391939 isoform X2 [Plutella xylostella] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 Q1JPB9 301 8.5e-26 Group 3 secretory phospholipase A2 OS=Bos taurus GN=PLA2G3 PE=2 SV=1 PF12678//PF00616 RING-H2 zinc finger//GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.15939 BP_3 33.82 0.73 2530 768440291 XP_011561813.1 652 4.1e-65 PREDICTED: uncharacterized protein LOC105391939 isoform X3 [Plutella xylostella] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P16354 302 6.5e-26 Phospholipase A2 isozymes PA3A/PA3B/PA5 OS=Heloderma suspectum PE=1 SV=3 PF12678//PF00616 RING-H2 zinc finger//GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.15940 BP_3 62.40 0.42 7535 591350379 XP_007069726.1 691 3.7e-69 PREDICTED: zinc finger protein 850-like [Chelonia mydas] 642917654 XM_008195282.1 761 0 PREDICTED: Tribolium castaneum zinc finger protein 502 (LOC100141877), mRNA -- -- -- -- P28698 639 1.6e-64 Myeloid zinc finger 1 OS=Homo sapiens GN=MZF1 PE=1 SV=3 PF06350//PF16622//PF13912//PF01155//PF07975//PF00096//PF13465 Hormone-sensitive lipase (HSL) N-terminus//zinc-finger C2H2-type//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0016042//GO:0006281//GO:0008203//GO:0006464 lipid catabolic process//DNA repair//cholesterol metabolic process//cellular protein modification process GO:0046872//GO:0016298//GO:0008270//GO:0016151 metal ion binding//lipase activity//zinc ion binding//nickel cation binding -- -- -- -- Cluster-8309.15943 BP_3 11.00 1.30 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15947 BP_3 30.94 0.32 4912 91092640 XP_969145.1 2958 0.0e+00 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1246 4.3e-135 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 PF00628 PHD-finger -- -- GO:0005515//GO:0043169 protein binding//cation binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.15948 BP_3 7.00 0.41 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1595 BP_3 18.23 0.68 1592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04790//PF10541 Sarcoglycan complex subunit protein//Nuclear envelope localisation domain -- -- -- -- GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.15951 BP_3 2.00 0.56 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15953 BP_3 1.00 0.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15956 BP_3 24.45 0.94 1542 815810117 XP_012225948.1 162 1.6e-08 PREDICTED: zinc finger and BTB domain-containing protein 24-like [Linepithema humile] -- -- -- -- -- -- -- -- -- P18729 135 9.1e-07 Gastrula zinc finger protein XlCGF57.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF13465//PF00096//PF00908//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//dTDP-4-dehydrorhamnose 3,5-epimerase//zinc-finger C2H2-type GO:0019872//GO:0030639//GO:0009117 streptomycin biosynthetic process//polyketide biosynthetic process//nucleotide metabolic process GO:0008830//GO:0046872 dTDP-4-dehydrorhamnose 3,5-epimerase activity//metal ion binding -- -- -- -- Cluster-8309.15961 BP_3 94.01 1.22 4016 91083749 XP_971342.1 2203 9.2e-245 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 1116 4.2e-120 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15962 BP_3 18.00 2.21 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15963 BP_3 129.50 4.78 1598 91086847 XP_974260.1 857 4.4e-89 PREDICTED: BSD domain-containing protein 1-B [Tribolium castaneum]>gi|270010460|gb|EFA06908.1| hypothetical protein TcasGA2_TC009857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BJ78 312 2.8e-27 BSD domain-containing protein 1 OS=Xenopus tropicalis GN=bsdc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2690 Uncharacterized conserved protein, contains BSD domain Cluster-8309.15965 BP_3 64.14 4.78 938 270010209 EFA06657.1 1046 3.1e-111 hypothetical protein TcasGA2_TC009583 [Tribolium castaneum] -- -- -- -- -- K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q01583 466 2.3e-45 Diacylglycerol kinase 1 OS=Drosophila melanogaster GN=Dgk PE=2 SV=5 PF13202//PF13833//PF00036//PF13405//PF13499 EF hand//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.15966 BP_3 19.60 0.81 1462 642927673 XP_008195359.1 1550 1.8e-169 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase 1 [Tribolium castaneum] 795069100 XM_012019555.1 194 9.36762e-95 PREDICTED: Vollenhovia emeryi diacylglycerol kinase 1 (LOC105565940), transcript variant X3, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q01583 1121 4.0e-121 Diacylglycerol kinase 1 OS=Drosophila melanogaster GN=Dgk PE=2 SV=5 PF00781//PF00130//PF13202//PF00036//PF00628//PF07649 Diacylglycerol kinase catalytic domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//EF hand//EF hand//PHD-finger//C1-like domain GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0005515//GO:0047134//GO:0005509//GO:0016301 protein binding//protein-disulfide reductase activity//calcium ion binding//kinase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.15968 BP_3 161.00 8.44 1211 189242406 XP_001810193.1 1389 6.8e-151 PREDICTED: peptidyl-prolyl cis-trans isomerase E [Tribolium castaneum]>gi|270016278|gb|EFA12724.1| hypothetical protein TcasGA2_TC002359 [Tribolium castaneum] 820862831 XM_012492661.1 108 4.95164e-47 PREDICTED: Apis florea peptidyl-prolyl cis-trans isomerase-like (LOC100866709), mRNA K09564 PPIE peptidyl-prolyl isomerase E (cyclophilin E) http://www.genome.jp/dbget-bin/www_bget?ko:K09564 A4FV72 1124 1.5e-121 Peptidyl-prolyl cis-trans isomerase E OS=Bos taurus GN=PPIE PE=2 SV=1 PF00076//PF16367//PF00160 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003676//GO:0003755//GO:0003723//GO:0000166 nucleic acid binding//peptidyl-prolyl cis-trans isomerase activity//RNA binding//nucleotide binding -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.15971 BP_3 65.59 1.46 2453 546680487 ERL90753.1 1333 4.3e-144 hypothetical protein D910_08100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Z136 313 3.3e-27 Hamartin OS=Rattus norvegicus GN=Tsc1 PE=1 SV=1 PF02465//PF06005 Flagellar hook-associated protein 2 N-terminus//Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly -- -- GO:0005737//GO:0009424 cytoplasm//bacterial-type flagellum hook KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.15974 BP_3 107.11 1.81 3146 478260277 ENN80029.1 3713 0.0e+00 hypothetical protein YQE_03506, partial [Dendroctonus ponderosae] 749790992 XM_011150385.1 92 1.0264e-37 PREDICTED: Harpegnathos saltator DNA replication licensing factor MCM4 (LOC105188757), transcript variant X3, mRNA K02212 MCM4, CDC54 DNA replication licensing factor MCM4 http://www.genome.jp/dbget-bin/www_bget?ko:K02212 Q26454 3288 0.0e+00 DNA replication licensing factor MCM4 OS=Drosophila melanogaster GN=dpa PE=1 SV=2 PF04055//PF07726//PF00493//PF07837//PF05460//PF03648//PF07728//PF13545//PF05669//PF00158//PF00004 Radical SAM superfamily//ATPase family associated with various cellular activities (AAA)//MCM2/3/5 family//Formiminotransferase domain, N-terminal subdomain//Origin recognition complex subunit 6 (ORC6)//Glycosyl hydrolase family 67 N-terminus//AAA domain (dynein-related subfamily)//Crp-like helix-turn-helix domain//SOH1//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA) GO:0006260//GO:0006355//GO:0005975//GO:0045493//GO:0008152 DNA replication//regulation of transcription, DNA-templated//carbohydrate metabolic process//xylan catabolic process//metabolic process GO:0016887//GO:0051536//GO:0016740//GO:0046559//GO:0005524//GO:0008134//GO:0005542//GO:0001104//GO:0003677//GO:0003824 ATPase activity//iron-sulfur cluster binding//transferase activity//alpha-glucuronidase activity//ATP binding//transcription factor binding//folic acid binding//RNA polymerase II transcription cofactor activity//DNA binding//catalytic activity GO:0016592//GO:0005664//GO:0005667 mediator complex//nuclear origin of replication recognition complex//transcription factor complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.15979 BP_3 47.61 1.65 1679 642929641 XP_008195916.1 174 7.3e-10 PREDICTED: uncharacterized protein LOC664363 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.1598 BP_3 1.14 1.03 338 642934331 XP_008198605.1 276 2.2e-22 PREDICTED: tripartite motif-containing protein 2 isoform X3 [Tribolium castaneum] 817086197 XM_012410395.1 50 2.24355e-15 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15980 BP_3 21.27 0.31 3625 86515396 NP_001034523.1 633 9.4e-63 cephalothorax [Tribolium castaneum]>gi|13241681|gb|AAK16422.1|AF321227_2 Scr [Tribolium castaneum]>gi|270002805|gb|EEZ99252.1| sex combs reduced [Tribolium castaneum] 86515395 NM_001039434.1 199 3.91343e-97 Tribolium castaneum cephalothorax (Cx), mRNA K09311 ANTP Antp family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09311 P09077 601 2.0e-60 Homeotic protein Sex combs reduced OS=Drosophila melanogaster GN=Scr PE=1 SV=5 PF09726//PF00046 Transmembrane protein//Homeobox domain GO:0007275//GO:0006355 multicellular organismal development//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0016021 transcription factor complex//nucleus//integral component of membrane -- -- Cluster-8309.15981 BP_3 35.57 0.73 2642 642912777 XP_008201245.1 612 1.9e-60 PREDICTED: cephalothorax isoform X1 [Tribolium castaneum] 642912776 XM_008203023.1 231 4.62551e-115 PREDICTED: Tribolium castaneum cephalothorax (Cx), transcript variant X1, mRNA K09304 HOX_4 homeobox protein HoxA/B/C/D4 http://www.genome.jp/dbget-bin/www_bget?ko:K09304 P09077 465 8.5e-45 Homeotic protein Sex combs reduced OS=Drosophila melanogaster GN=Scr PE=1 SV=5 PF00046//PF09726 Homeobox domain//Transmembrane protein -- -- GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.15982 BP_3 250.16 4.87 2768 86515396 NP_001034523.1 633 7.2e-63 cephalothorax [Tribolium castaneum]>gi|13241681|gb|AAK16422.1|AF321227_2 Scr [Tribolium castaneum]>gi|270002805|gb|EEZ99252.1| sex combs reduced [Tribolium castaneum] 86515395 NM_001039434.1 286 1.29131e-145 Tribolium castaneum cephalothorax (Cx), mRNA K09311 ANTP Antp family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09311 P09077 601 1.5e-60 Homeotic protein Sex combs reduced OS=Drosophila melanogaster GN=Scr PE=1 SV=5 PF09726//PF00046 Transmembrane protein//Homeobox domain GO:0007275//GO:0006355 multicellular organismal development//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0016021 transcription factor complex//nucleus//integral component of membrane -- -- Cluster-8309.15986 BP_3 286.00 12.74 1374 332375817 AEE63049.1 943 4.0e-99 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14823 EBP2, EBNA1BP2 rRNA-processing protein EBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14823 Q9V9Z9 667 1.7e-68 Probable rRNA-processing protein EBP2 homolog OS=Drosophila melanogaster GN=CG1542 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3080 Nucleolar protein-like/EBNA1-binding protein Cluster-8309.1599 BP_3 100.87 4.68 1331 642917708 XP_008191339.1 552 8.5e-54 PREDICTED: insulin-like growth factor-binding protein 7 [Tribolium castaneum]>gi|270004468|gb|EFA00916.1| hypothetical protein TcasGA2_TC003822 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-8309.15990 BP_3 5.09 0.35 984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15995 BP_3 3.00 0.40 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15996 BP_3 36.00 0.88 2253 641657886 XP_008180508.1 812 1.0e-83 PREDICTED: zinc finger MYM-type protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q5SVZ6 297 2.2e-25 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 PF04088 Peroxin 13, N-terminal region GO:0016560 protein import into peroxisome matrix, docking -- -- GO:0005777//GO:0016021 peroxisome//integral component of membrane -- -- Cluster-8309.15997 BP_3 8.00 0.69 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15999 BP_3 4.00 1.48 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16 BP_3 31.00 0.89 1976 642929701 XP_008195941.1 147 1.2e-06 PREDICTED: uncharacterized protein LOC103313715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1600 BP_3 14.13 2.58 556 642917708 XP_008191339.1 294 2.9e-24 PREDICTED: insulin-like growth factor-binding protein 7 [Tribolium castaneum]>gi|270004468|gb|EFA00916.1| hypothetical protein TcasGA2_TC003822 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0016942//GO:0005576 insulin-like growth factor binding protein complex//extracellular region -- -- Cluster-8309.16000 BP_3 180.33 0.74 12021 642921923 XP_008192946.1 150 3.2e-06 PREDICTED: eukaryotic translation initiation factor 4 gamma 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17122 Zinc-finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.16001 BP_3 11.00 2.89 475 123471670 XP_001319033.1 317 5.4e-27 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121901807|gb|EAY06810.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q9VUX2 252 7.6e-21 E3 ubiquitin-protein ligase mind-bomb OS=Drosophila melanogaster GN=mib1 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.16004 BP_3 84.37 3.08 1611 642921705 XP_008194745.1 1045 7.0e-111 PREDICTED: peroxisome biogenesis factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P24392 380 3.7e-35 Peroxisome biogenesis factor 2 OS=Rattus norvegicus GN=Pex2 PE=2 SV=1 PF16685//PF13639//PF14634//PF00097 zinc RING finger of MSL2//Ring finger domain//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0061630//GO:0005515//GO:0046872//GO:0008270 ubiquitin protein ligase activity//protein binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.16006 BP_3 4.00 0.35 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16007 BP_3 62.18 0.59 5354 478251798 ENN72244.1 2578 4.0e-288 hypothetical protein YQE_11107, partial [Dendroctonus ponderosae] 642923087 XM_967659.3 120 4.77739e-53 PREDICTED: Tribolium castaneum hemocyte protein-glutamine gamma-glutamyltransferase (LOC661504), mRNA K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 Q05187 1770 8.2e-196 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00927//PF00868 Transglutaminase family, C-terminal ig like domain//Transglutaminase family GO:0018149 peptide cross-linking GO:0003810 protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.16009 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1601 BP_3 9.18 0.36 1514 68448544 NP_001020330.1 1552 1.1e-169 HLA class II histocompatibility antigen gamma chain isoform a [Homo sapiens]>gi|20178292|sp|P04233.3|HG2A_HUMAN RecName: Full=HLA class II histocompatibility antigen gamma chain; AltName: Full=HLA-DR antigens-associated invariant chain; AltName: Full=Ia antigen-associated invariant chain; Short=Ii; AltName: Full=p33; AltName: CD_antigen=CD74>gi|119582135|gb|EAW61731.1| CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), isoform CRA_c [Homo sapiens]>gi|194388484|dbj|BAG60210.1| unnamed protein product [Homo sapiens] 343403785 NM_001025159.2 1490 0 Homo sapiens CD74 molecule, major histocompatibility complex, class II invariant chain (CD74), transcript variant 1, mRNA K06505 CD74, DHLAG CD74 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06505 P04233 1552 4.4e-171 HLA class II histocompatibility antigen gamma chain OS=Homo sapiens GN=CD74 PE=1 SV=3 PF08831//PF09307 Class II MHC-associated invariant chain trimerisation domain//CLIP, MHC2 interacting GO:0060907//GO:0045582//GO:0048146//GO:0019883//GO:0001516//GO:0001961//GO:0007165//GO:0045581//GO:0070374//GO:0006952//GO:0006886//GO:0002830//GO:0006955//GO:0043518//GO:0000187//GO:0051085//GO:0019882//GO:0016064//GO:0045060//GO:0019886//GO:0045059//GO:0030890//GO:0050731//GO:0035691//GO:0002906//GO:0043030//GO:0006461//GO:0002792//GO:2000343//GO:0090023//GO:0002606 positive regulation of macrophage cytokine production//positive regulation of T cell differentiation//positive regulation of fibroblast proliferation//antigen processing and presentation of endogenous antigen//prostaglandin biosynthetic process//positive regulation of cytokine-mediated signaling pathway//signal transduction//negative regulation of T cell differentiation//positive regulation of ERK1 and ERK2 cascade//defense response//intracellular protein transport//positive regulation of type 2 immune response//immune response//negative regulation of DNA damage response, signal transduction by p53 class mediator//activation of MAPK activity//chaperone mediated protein folding requiring cofactor//antigen processing and presentation//immunoglobulin mediated immune response//negative thymic T cell selection//antigen processing and presentation of exogenous peptide antigen via MHC class II//positive thymic T cell selection//positive regulation of B cell proliferation//positive regulation of peptidyl-tyrosine phosphorylation//macrophage migration inhibitory factor signaling pathway//negative regulation of mature B cell apoptotic process//regulation of macrophage activation//protein complex assembly//negative regulation of peptide secretion//positive regulation of chemokine (C-X-C motif) ligand 2 production//positive regulation of neutrophil chemotaxis//positive regulation of dendritic cell antigen processing and presentation GO:0042802//GO:0035718//GO:0042289//GO:0004896//GO:0001540//GO:0050998 identical protein binding//macrophage migration inhibitory factor binding//MHC class II protein binding//cytokine receptor activity//beta-amyloid binding//nitric-oxide synthase binding GO:0005765//GO:0042613//GO:0030669//GO:0016020//GO:0012507//GO:0032588//GO:0043202//GO:0035693//GO:0000139//GO:0005771//GO:0009897//GO:0071556//GO:0035692 lysosomal membrane//MHC class II protein complex//clathrin-coated endocytic vesicle membrane//membrane//ER to Golgi transport vesicle membrane//trans-Golgi network membrane//lysosomal lumen//NOS2-CD74 complex//Golgi membrane//multivesicular body//external side of plasma membrane//integral component of lumenal side of endoplasmic reticulum membrane//macrophage migration inhibitory factor receptor complex -- -- Cluster-8309.16016 BP_3 291.19 32.47 724 478262795 ENN81312.1 636 8.4e-64 hypothetical protein YQE_02280, partial [Dendroctonus ponderosae]>gi|546672916|gb|ERL84632.1| hypothetical protein D910_02060 [Dendroctonus ponderosae] -- -- -- -- -- K05019 CLNS1A chloride channel, nucleotide-sensitive, 1A http://www.genome.jp/dbget-bin/www_bget?ko:K05019 P54106 247 4.4e-20 Methylosome subunit pICln OS=Xenopus laevis GN=clns1a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1602 BP_3 64.61 1.97 1872 270001961 EEZ98408.1 969 5.3e-102 hypothetical protein TcasGA2_TC000876 [Tribolium castaneum] -- -- -- -- -- K00486 KMO kynurenine 3-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00486 Q7Q6A7 857 2.1e-90 Kynurenine 3-monooxygenase OS=Anopheles gambiae GN=kh PE=3 SV=2 PF03721//PF00070//PF01210//PF02558//PF01134//PF01266//PF08491//PF12831//PF02515//PF02737//PF07992//PF01494 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A//FAD dependent oxidoreductase//Squalene epoxidase//FAD dependent oxidoreductase//CoA-transferase family III//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain GO:0006552//GO:0006631//GO:0018874//GO:0006633//GO:0046168//GO:0006694//GO:0055114//GO:0006554//GO:0008033//GO:0006568//GO:0016114//GO:0006550//GO:0006574//GO:0015940 leucine catabolic process//fatty acid metabolic process//benzoate metabolic process//fatty acid biosynthetic process//glycerol-3-phosphate catabolic process//steroid biosynthetic process//oxidation-reduction process//lysine catabolic process//tRNA processing//tryptophan metabolic process//terpenoid biosynthetic process//isoleucine catabolic process//valine catabolic process//pantothenate biosynthetic process GO:0050660//GO:0008677//GO:0051287//GO:0016491//GO:0003824//GO:0004506//GO:0003857//GO:0016616//GO:0071949 flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//NAD binding//oxidoreductase activity//catalytic activity//squalene monooxygenase activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//FAD binding GO:0016021 integral component of membrane KOG2614 Kynurenine 3-monooxygenase and related flavoprotein monooxygenases Cluster-8309.16022 BP_3 213.76 2.95 3783 642910693 XP_008200063.1 3431 0.0e+00 PREDICTED: neurogenic locus protein delta [Tribolium castaneum]>gi|270014506|gb|EFA10954.1| hypothetical protein TcasGA2_TC004114 [Tribolium castaneum] 642910692 XM_008201841.1 761 0 PREDICTED: Tribolium castaneum neurogenic locus protein delta (LOC658619), mRNA K06051 DLL delta http://www.genome.jp/dbget-bin/www_bget?ko:K06051 Q9IAT6 1432 9.0e-157 Delta-like protein C OS=Danio rerio GN=dlc PE=2 SV=1 PF07645//PF00008//PF01414//PF07657 Calcium-binding EGF domain//EGF-like domain//Delta serrate ligand//N terminus of Notch ligand GO:0007154//GO:0007219//GO:0007275 cell communication//Notch signaling pathway//multicellular organismal development GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.16024 BP_3 199.00 3.52 3020 91087773 XP_975069.1 886 3.6e-92 PREDICTED: uncharacterized protein LOC663949 [Tribolium castaneum]>gi|270010747|gb|EFA07195.1| hypothetical protein TcasGA2_TC010201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.16026 BP_3 2.24 0.38 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16028 BP_3 3.22 1.73 379 829834934 XP_012634083.1 251 1.9e-19 PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834939|ref|XP_012634084.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834943|ref|XP_012634086.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834947|ref|XP_012634087.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834951|ref|XP_012634088.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834956|ref|XP_012634089.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834961|ref|XP_012634090.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834966|ref|XP_012634091.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834971|ref|XP_012634092.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834976|ref|XP_012634093.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834981|ref|XP_012634094.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834985|ref|XP_012634095.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834990|ref|XP_012634097.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834999|ref|XP_012634099.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16033 BP_3 47.00 0.36 6602 270004828 EFA01276.1 2217 3.6e-246 roundabout [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HCK4 504 6.4e-49 Roundabout homolog 2 OS=Homo sapiens GN=ROBO2 PE=1 SV=2 PF07578//PF13895//PF00041//PF16656 Lipid A Biosynthesis N-terminal domain//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0009245//GO:0019497 riboflavin metabolic process//lipid A biosynthetic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0008915//GO:0005515 acid phosphatase activity//metal ion binding//lipid-A-disaccharide synthase activity//protein binding -- -- KOG4222 Axon guidance receptor Dscam Cluster-8309.16034 BP_3 852.61 8.63 5052 642917061 XP_008191104.1 4043 0.0e+00 PREDICTED: roundabout homolog 2 [Tribolium castaneum] 642917060 XM_008192882.1 512 0 PREDICTED: Tribolium castaneum roundabout (LOC655427), mRNA K06754 ROBO2 roundabout, axon guidance receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06754 Q9HCK4 1513 4.9e-166 Roundabout homolog 2 OS=Homo sapiens GN=ROBO2 PE=1 SV=2 PF07578//PF16656//PF00041//PF13895 Lipid A Biosynthesis N-terminal domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0019497//GO:0009245//GO:0006771 hexachlorocyclohexane metabolic process//lipid A biosynthetic process//riboflavin metabolic process GO:0005515//GO:0008915//GO:0046872//GO:0003993 protein binding//lipid-A-disaccharide synthase activity//metal ion binding//acid phosphatase activity -- -- KOG4222 Axon guidance receptor Dscam Cluster-8309.16035 BP_3 6.00 2.11 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16037 BP_3 31.00 1.70 1169 262401027 ACY66416.1 599 2.6e-59 cytochrome c oxidase polypeptide IV [Scylla paramamosain] 262401026 FJ774694.1 343 1.10452e-177 Scylla paramamosain cytochrome c oxidase polypeptide IV mRNA, partial cds K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 337 2.6e-30 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 PF02936 Cytochrome c oxidase subunit IV GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.16038 BP_3 13.39 0.73 1176 260831005 XP_002610450.1 225 6.2e-16 hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae]>gi|229295816|gb|EEN66460.1| hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.16039 BP_3 10.15 0.65 1039 260831005 XP_002610450.1 157 4.2e-08 hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae]>gi|229295816|gb|EEN66460.1| hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.16041 BP_3 107.28 2.18 2664 91088919 XP_973208.1 1394 3.9e-151 PREDICTED: protein asunder [Tribolium castaneum]>gi|270012357|gb|EFA08805.1| hypothetical protein TcasGA2_TC006499 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JHB4 825 1.5e-86 Protein asunder OS=Drosophila grimshawi GN=asun PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3711 Uncharacterized conserved protein Cluster-8309.16042 BP_3 87.31 1.98 2416 91088919 XP_973208.1 2763 6.4e-310 PREDICTED: protein asunder [Tribolium castaneum]>gi|270012357|gb|EFA08805.1| hypothetical protein TcasGA2_TC006499 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8QZV7 1425 3.7e-156 Protein asunder homolog OS=Mus musculus GN=Asun PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3711 Uncharacterized conserved protein Cluster-8309.16043 BP_3 45.61 0.84 2895 642938194 XP_008191102.1 334 3.5e-28 PREDICTED: uncharacterized protein LOC103312382 isoform X1 [Tribolium castaneum]>gi|270016585|gb|EFA13031.1| hypothetical protein TcasGA2_TC010561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16044 BP_3 18.00 0.58 1793 746831190 XP_011051651.1 633 4.6e-63 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Acromyrmex echinatior] 807022049 XM_012299906.1 181 1.94484e-87 PREDICTED: Ceratitis capitata uncharacterized LOC101451678 (LOC101451678), transcript variant X4, mRNA -- -- -- -- Q7JQ07 250 4.9e-20 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF00665//PF12678 Integrase core domain//RING-H2 zinc finger GO:0015074 DNA integration GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.16046 BP_3 238.00 7.45 1831 91094103 XP_967297.1 1683 8.3e-185 PREDICTED: trafficking protein particle complex subunit 13 [Tribolium castaneum]>gi|270010876|gb|EFA07324.1| hypothetical protein TcasGA2_TC015920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBY7 1085 7.5e-117 Trafficking protein particle complex subunit 13 OS=Danio rerio GN=trappc13 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2625 Uncharacterized conserved protein Cluster-8309.16051 BP_3 114.42 0.64 8905 546675135 ERL86379.1 900 2.5e-93 hypothetical protein D910_03787, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N2G6 656 2.0e-66 Zinc finger CCHC domain-containing protein 24 OS=Homo sapiens GN=ZCCHC24 PE=1 SV=1 PF00098//PF05495 Zinc knuckle//CHY zinc finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.16052 BP_3 80.63 0.77 5324 780721058 XP_011706943.1 987 1.2e-103 PREDICTED: uncharacterized protein LOC105462109, partial [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09637//PF00665//PF13085 Med18 protein//Integrase core domain//2Fe-2S iron-sulfur cluster binding domain GO:0015074//GO:0006118//GO:0006357 DNA integration//obsolete electron transport//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0051536//GO:0009055 RNA polymerase II transcription cofactor activity//iron-sulfur cluster binding//electron carrier activity GO:0016592 mediator complex -- -- Cluster-8309.16053 BP_3 105.55 5.29 1254 91078614 XP_967493.1 1120 1.1e-119 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 238 2.77807e-119 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 O43752 576 5.4e-58 Syntaxin-6 OS=Homo sapiens GN=STX6 PE=1 SV=1 PF05478//PF09177//PF05739//PF04871//PF04108 Prominin//Syntaxin 6, N-terminal//SNARE domain//Uso1 / p115 like vesicle tethering protein, C terminal region//Autophagy protein Apg17 GO:0006914//GO:0006886//GO:0048193//GO:0015031 autophagy//intracellular protein transport//Golgi vesicle transport//protein transport GO:0005515//GO:0008565 protein binding//protein transporter activity GO:0016021//GO:0016020//GO:0005737 integral component of membrane//membrane//cytoplasm KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.16055 BP_3 128.39 1.69 3957 270015323 EFA11771.1 1360 5.1e-147 hypothetical protein TcasGA2_TC004098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NBX4 1138 1.2e-122 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 PF01239//PF00098//PF00628 Protein prenyltransferase alpha subunit repeat//Zinc knuckle//PHD-finger GO:0018342 protein prenylation GO:0005515//GO:0003676//GO:0008318//GO:0008270 protein binding//nucleic acid binding//protein prenyltransferase activity//zinc ion binding -- -- -- -- Cluster-8309.16062 BP_3 3599.00 70.94 2737 332375849 AEE63065.1 995 7.5e-105 unknown [Dendroctonus ponderosae]>gi|478259872|gb|ENN79690.1| hypothetical protein YQE_03870, partial [Dendroctonus ponderosae]>gi|546684339|gb|ERL94044.1| hypothetical protein D910_11327 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O76879 181 7.5e-12 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16070 BP_3 3.00 0.56 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16082 BP_3 78.41 6.48 875 861436651 XP_012927760.1 549 1.2e-53 PREDICTED: POC1 centriolar protein homolog B isoform X1 [Heterocephalus glaber] -- -- -- -- -- K16482 POC1 centriolar protein POC1 http://www.genome.jp/dbget-bin/www_bget?ko:K16482 Q7ZVF0 547 8.7e-55 POC1 centriolar protein homolog A OS=Danio rerio GN=poc1a PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.1609 BP_3 1563.00 147.06 804 546680074 ERL90426.1 817 9.6e-85 hypothetical protein D910_07775 [Dendroctonus ponderosae] 153929692 AK284310.1 58 2.02216e-19 Gryllus bimaculatus mRNA, GBcontig31171 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16091 BP_3 113.78 9.53 867 546684171 ERL93876.1 426 2.3e-39 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- K15053 CHMP7 charged multivesicular body protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15053 -- -- -- -- PF03357//PF04508 Snf7//Viral A-type inclusion protein repeat GO:0007034//GO:0016032 vacuolar transport//viral process -- -- -- -- -- -- Cluster-8309.16092 BP_3 57.69 0.69 4312 546684171 ERL93876.1 1173 2.7e-125 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- K10262 FBXW4, SHFM3 F-box and WD-40 domain protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10262 P57775 435 4.2e-41 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF12937//PF03357//PF15966//PF00400//PF00646//PF01442 F-box-like//Snf7//F-box//WD domain, G-beta repeat//F-box domain//Apolipoprotein A1/A4/E domain GO:0006869//GO:0007034//GO:0042157 lipid transport//vacuolar transport//lipoprotein metabolic process GO:0005515//GO:0008289 protein binding//lipid binding GO:0005576 extracellular region KOG2911 Uncharacterized conserved protein Cluster-8309.16093 BP_3 16.00 0.34 2588 646701284 KDR11089.1 2648 1.5e-296 Calsyntenin-1 [Zootermopsis nevadensis] 27571845 BX022625.1 80 3.94918e-31 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAA34CE04 of strain 6-9 of Anopheles gambiae (African malaria mosquito) -- -- -- -- Q9V498 1603 9.1e-177 Calsyntenin-1 OS=Drosophila melanogaster GN=Cals PE=1 SV=2 PF10717//PF00722//PF00028//PF10417 Occlusion-derived virus envelope protein ODV-E18//Glycosyl hydrolases family 16//Cadherin domain//C-terminal domain of 1-Cys peroxiredoxin GO:0007156//GO:0005975//GO:0055114 homophilic cell adhesion via plasma membrane adhesion molecules//carbohydrate metabolic process//oxidation-reduction process GO:0051920//GO:0004553//GO:0005509 peroxiredoxin activity//hydrolase activity, hydrolyzing O-glycosyl compounds//calcium ion binding GO:0019031//GO:0016020 viral envelope//membrane KOG3594 FOG: Cadherin repeats Cluster-8309.16097 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16098 BP_3 3205.35 73.59 2391 549438523 AGX25150.1 2410 5.4e-269 serine proteinase inhibitor, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- A2ASQ1 315 1.9e-27 Agrin OS=Mus musculus GN=Agrn PE=1 SV=1 PF02456//PF00050//PF07648 Adenovirus IVa2 protein//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0019083 viral transcription GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.161 BP_3 7.00 0.71 767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1610 BP_3 727.00 64.74 833 270003581 EFA00029.1 736 2.4e-75 hypothetical protein TcasGA2_TC002836 [Tribolium castaneum] 153929692 AK284310.1 81 3.4375e-32 Gryllus bimaculatus mRNA, GBcontig31171 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16102 BP_3 3.00 1.30 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16105 BP_3 7.00 0.32 1343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16107 BP_3 2.96 1.30 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16108 BP_3 79.04 15.91 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16109 BP_3 42.41 1.10 2152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04851 Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003677//GO:0016787 ATP binding//DNA binding//hydrolase activity -- -- -- -- Cluster-8309.16113 BP_3 2.00 1.61 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16116 BP_3 165.34 3.37 2659 91078380 XP_974219.1 314 6.7e-26 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P93748 186 1.9e-12 Putative E3 ubiquitin-protein ligase SINAT1 OS=Arabidopsis thaliana GN=SINAT1 PE=3 SV=1 PF03145//PF05353//PF02176 Seven in absentia protein family//Delta Atracotoxin//TRAF-type zinc finger GO:0006511//GO:0006810//GO:0007275//GO:0009405 ubiquitin-dependent protein catabolic process//transport//multicellular organismal development//pathogenesis GO:0019871//GO:0008270 sodium channel inhibitor activity//zinc ion binding GO:0005576//GO:0005634 extracellular region//nucleus -- -- Cluster-8309.16118 BP_3 20.00 0.84 1442 807041545 XP_012161435.1 158 4.5e-08 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like [Ceratitis capitata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16121 BP_3 18.79 0.31 3217 817212181 XP_012282266.1 793 2.3e-81 PREDICTED: uncharacterized protein LOC105700713 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02563//PF02066 Polysaccharide biosynthesis/export protein//Metallothionein family 11 GO:0015774 polysaccharide transport GO:0015159//GO:0005507 polysaccharide transmembrane transporter activity//copper ion binding GO:0016020 membrane -- -- Cluster-8309.16126 BP_3 28.33 0.44 3407 189238203 XP_001809288.1 993 1.6e-104 PREDICTED: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y6J9 161 2.0e-09 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens GN=TAF6L PE=1 SV=1 PF05482//PF01044//PF02969 Serendipity locus alpha protein (SRY-A)//Vinculin family//TATA box binding protein associated factor (TAF) GO:0006352//GO:0007349//GO:0007155 DNA-templated transcription, initiation//cellularization//cell adhesion GO:0051015 actin filament binding GO:0005737//GO:0016020//GO:0005634 cytoplasm//membrane//nucleus KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.16131 BP_3 119.34 1.07 5674 546675155 ERL86391.1 1444 1.3e-156 hypothetical protein D910_03799 [Dendroctonus ponderosae] -- -- -- -- -- K14859 SSF1_2 ribosome biogenesis protein SSF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14859 Q9VDE5 984 1.2e-104 Protein Peter pan OS=Drosophila melanogaster GN=ppan PE=1 SV=1 PF01555//PF13181//PF02384//PF05944//PF14863//PF02086//PF14721//PF13414//PF13371//PF00515 DNA methylase//Tetratricopeptide repeat//N-6 DNA Methylase//Phage small terminase subunit//Alkyl sulfatase dimerisation//D12 class N6 adenine-specific DNA methyltransferase//Apoptosis-inducing factor, mitochondrion-associated, C-term//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006306//GO:0019069//GO:0032775 DNA methylation//viral capsid assembly//DNA methylation on adenine GO:0008170//GO:0009007//GO:0003677//GO:0004519//GO:0005515//GO:0046983 N-methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//DNA binding//endonuclease activity//protein binding//protein dimerization activity -- -- KOG2963 RNA-binding protein required for 60S ribosomal subunit biogenesis Cluster-8309.16134 BP_3 22.85 0.37 3259 815765768 XP_012215589.1 168 7.0e-09 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.16137 BP_3 119.55 2.69 2437 815765768 XP_012215589.1 186 4.3e-11 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q9D305 146 7.7e-08 THAP domain-containing protein 2 OS=Mus musculus GN=Thap2 PE=2 SV=1 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16138 BP_3 12.00 1.40 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16139 BP_3 394.37 4.79 4263 642928261 XP_008195511.1 1481 5.1e-161 PREDICTED: leucine-rich repeat-containing protein 49 [Tribolium castaneum] -- -- -- -- -- K16606 LRRC49 leucine-rich repeat-containing protein 49 http://www.genome.jp/dbget-bin/www_bget?ko:K16606 Q91YK0 494 5.9e-48 Leucine-rich repeat-containing protein 49 OS=Mus musculus GN=Lrrc49 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.16142 BP_3 2.00 13.11 255 817218311 XP_012285007.1 142 5.6e-07 PREDICTED: uncharacterized protein LOC105702207 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16143 BP_3 12.24 0.33 2070 270006572 EFA03020.1 832 4.5e-86 hypothetical protein TcasGA2_TC010443 [Tribolium castaneum] -- -- -- -- -- K07478 ycaJ putative ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K07478 Q8CG07 564 2.2e-56 ATPase WRNIP1 OS=Rattus norvegicus GN=Wrnip1 PE=2 SV=1 PF07724//PF06068//PF05496//PF01443//PF14532//PF00910//PF04851//PF01637//PF07726//PF00004//PF00158//PF07728//PF01695//PF00931//PF01363//PF15926 AAA domain (Cdc48 subfamily)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//Sigma-54 interaction domain//RNA helicase//Type III restriction enzyme, res subunit//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//NB-ARC domain//FYVE zinc finger//E3 ubiquitin-protein ligase RNF220 GO:0016567//GO:0006310//GO:0006281//GO:0090263//GO:0006355 protein ubiquitination//DNA recombination//DNA repair//positive regulation of canonical Wnt signaling pathway//regulation of transcription, DNA-templated GO:0043531//GO:0003723//GO:0003678//GO:0003677//GO:0003724//GO:0046872//GO:0009378//GO:0008134//GO:0005524//GO:0016787//GO:0016887 ADP binding//RNA binding//DNA helicase activity//DNA binding//RNA helicase activity//metal ion binding//four-way junction helicase activity//transcription factor binding//ATP binding//hydrolase activity//ATPase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase Cluster-8309.16144 BP_3 12.20 0.52 1414 260835964 XP_002612977.1 167 4.0e-09 hypothetical protein BRAFLDRAFT_143777 [Branchiostoma floridae]>gi|229298359|gb|EEN68986.1| hypothetical protein BRAFLDRAFT_143777, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16145 BP_3 2.00 0.46 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16147 BP_3 26.00 1.22 1315 470437283 XP_004338972.1 1112 9.7e-119 adenine nucleotide translocator, putative [Acanthamoeba castellanii str. Neff]>gi|440795845|gb|ELR16959.1| adenine nucleotide translocator, putative [Acanthamoeba castellanii str. Neff] 697083105 XM_009656440.1 1303 0 Verticillium dahliae VdLs.17 ADP,ATP carrier protein mRNA K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 P02723 1333 9.5e-146 ADP,ATP carrier protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=aac PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.16148 BP_3 61.73 1.07 3081 642910461 XP_008190748.1 1890 1.4e-208 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] 462340826 APGK01036266.1 75 2.83395e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1134 2.6e-122 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF06305//PF07714//PF00069 Protein of unknown function (DUF1049)//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.16154 BP_3 921.39 9.12 5163 110431376 NP_001036036.1 2891 0.0e+00 short gastrulation precursor [Tribolium castaneum]>gi|94483096|gb|ABF22614.1| short gastrulation [Tribolium castaneum] -- -- -- -- -- K04657 CHRD chordin http://www.genome.jp/dbget-bin/www_bget?ko:K04657 Q24025 1934 7.6e-215 Dorsal-ventral patterning protein Sog OS=Drosophila melanogaster GN=sog PE=1 SV=1 PF00093//PF15957 von Willebrand factor type C domain//Commissureless GO:0007411 axon guidance GO:0005515 protein binding -- -- -- -- Cluster-8309.16158 BP_3 3.00 0.93 446 546681620 ERL91681.1 252 1.7e-19 hypothetical protein D910_09008 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16159 BP_3 20.33 0.74 1607 641672407 XP_008185929.1 597 6.2e-59 PREDICTED: uncharacterized protein LOC103310210 [Acyrthosiphon pisum] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 227 2.0e-17 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG3591 Alpha crystallins Cluster-8309.16164 BP_3 56.00 1.46 2136 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16165 BP_3 7.00 0.56 891 546678121 ERL88830.1 337 4.8e-29 hypothetical protein D910_06212 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8VHZ8 151 7.3e-09 Down syndrome cell adhesion molecule homolog OS=Rattus norvegicus GN=Dscam PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16169 BP_3 28.00 1.23 1387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16173 BP_3 3.30 1.30 413 270002553 EEZ99000.1 327 3.2e-28 hypothetical protein TcasGA2_TC004861 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9CPV7 154 1.5e-09 Palmitoyltransferase ZDHHC6 OS=Mus musculus GN=Zdhhc6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16174 BP_3 345.75 14.06 1477 91076372 XP_967795.1 1477 5.2e-161 PREDICTED: palmitoyltransferase ZDHHC6 [Tribolium castaneum] 871251020 XM_005104281.2 41 1.06758e-09 PREDICTED: Aplysia californica palmitoyltransferase ZDHHC6-like (LOC101847980), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q2HJ95 841 1.2e-88 Palmitoyltransferase ZDHHC6 OS=Bos taurus GN=ZDHHC6 PE=2 SV=1 PF01363//PF01529 FYVE zinc finger//DHHC palmitoyltransferase -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1314 DHHC-type Zn-finger protein Cluster-8309.16181 BP_3 31.26 0.63 2683 478254666 ENN74907.1 1583 4.8e-173 hypothetical protein YQE_08485, partial [Dendroctonus ponderosae] -- -- -- -- -- K18085 MTMR10_11_12 myotubularin-related protein 10/11/12 http://www.genome.jp/dbget-bin/www_bget?ko:K18085 Q6NU08 595 7.3e-60 Myotubularin-related protein 10-B OS=Xenopus laevis GN=mtmr10-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.16182 BP_3 301.44 8.46 2010 478254477 ENN74726.1 1349 4.9e-146 hypothetical protein YQE_08693, partial [Dendroctonus ponderosae]>gi|546685047|gb|ERL94601.1| hypothetical protein D910_11878 [Dendroctonus ponderosae] -- -- -- -- -- K13205 AAR2, C20orf4 A1 cistron-splicing factor AAR2 http://www.genome.jp/dbget-bin/www_bget?ko:K13205 Q08DJ7 779 2.5e-81 Protein AAR2 homolog OS=Bos taurus GN=AAR2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3937 mRNA splicing factor Cluster-8309.16183 BP_3 41.90 1.40 1733 478250692 ENN71184.1 1414 1.2e-153 hypothetical protein YQE_12114, partial [Dendroctonus ponderosae]>gi|546678623|gb|ERL89205.1| hypothetical protein D910_06579 [Dendroctonus ponderosae] -- -- -- -- -- K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 464 7.3e-45 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00098//PF00852 Zinc knuckle//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008270//GO:0008417//GO:0003676 zinc ion binding//fucosyltransferase activity//nucleic acid binding GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.16187 BP_3 1.41 0.42 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16188 BP_3 83.34 0.54 7740 859132808 AKO63318.1 2842 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2206 3.3e-246 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF13639//PF00368//PF02460//PF00283//PF17123//PF00643//PF00628//PF14634 Ring finger domain//Hydroxymethylglutaryl-coenzyme A reductase//Patched family//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//RING-like zinc finger//B-box zinc finger//PHD-finger//zinc-RING finger domain GO:0015936//GO:0006694//GO:0055114//GO:0015979//GO:0007165 coenzyme A metabolic process//steroid biosynthetic process//oxidation-reduction process//photosynthesis//signal transduction GO:0004420//GO:0008270//GO:0008158//GO:0050662//GO:0005515 hydroxymethylglutaryl-CoA reductase (NADPH) activity//zinc ion binding//hedgehog receptor activity//coenzyme binding//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.16189 BP_3 89.64 0.56 7955 859132808 AKO63318.1 2842 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2206 3.4e-246 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF02932//PF02460//PF00283//PF17123//PF00628//PF00643//PF14634//PF13639//PF00368 Neurotransmitter-gated ion-channel transmembrane region//Patched family//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//RING-like zinc finger//PHD-finger//B-box zinc finger//zinc-RING finger domain//Ring finger domain//Hydroxymethylglutaryl-coenzyme A reductase GO:0015979//GO:0007165//GO:0015936//GO:0006811//GO:0055114//GO:0006694 photosynthesis//signal transduction//coenzyme A metabolic process//ion transport//oxidation-reduction process//steroid biosynthetic process GO:0008158//GO:0050662//GO:0005515//GO:0004420//GO:0008270 hedgehog receptor activity//coenzyme binding//protein binding//hydroxymethylglutaryl-CoA reductase (NADPH) activity//zinc ion binding GO:0016020//GO:0005622 membrane//intracellular KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.1619 BP_3 1483.00 74.28 1254 270015668 EFA12116.1 1178 2.1e-126 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q96NR8 398 2.4e-37 Retinol dehydrogenase 12 OS=Homo sapiens GN=RDH12 PE=1 SV=3 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.16190 BP_3 317.40 2.03 7814 859132808 AKO63318.1 2842 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2206 3.3e-246 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF17123//PF00283//PF00643//PF00628//PF14634//PF02460//PF00368//PF13639 RING-like zinc finger//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//B-box zinc finger//PHD-finger//zinc-RING finger domain//Patched family//Hydroxymethylglutaryl-coenzyme A reductase//Ring finger domain GO:0015936//GO:0006694//GO:0055114//GO:0015979//GO:0007165 coenzyme A metabolic process//steroid biosynthetic process//oxidation-reduction process//photosynthesis//signal transduction GO:0004420//GO:0008270//GO:0050662//GO:0008158//GO:0005515 hydroxymethylglutaryl-CoA reductase (NADPH) activity//zinc ion binding//coenzyme binding//hedgehog receptor activity//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.16193 BP_3 17.88 0.87 1287 546674232 ERL85660.1 170 1.6e-09 hypothetical protein D910_03077 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00737 Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0042301 phosphate ion binding GO:0016020//GO:0009523 membrane//photosystem II -- -- Cluster-8309.16194 BP_3 30.00 0.93 1845 571330962 AHF27413.1 1578 1.3e-172 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A9ZSY3 473 7.0e-46 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.16195 BP_3 19.00 0.35 2924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04644//PF00771//PF02891//PF09339 Motilin/ghrelin//FHIPEP family//MIZ/SP-RING zinc finger//IclR helix-turn-helix domain GO:0006355//GO:0007165//GO:0009306 regulation of transcription, DNA-templated//signal transduction//protein secretion GO:0008270//GO:0003677//GO:0005179 zinc ion binding//DNA binding//hormone activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.16197 BP_3 311.35 4.36 3730 91079028 XP_974924.1 1752 1.7e-192 PREDICTED: glutamate-rich WD repeat-containing protein 1 [Tribolium castaneum]>gi|270004178|gb|EFA00626.1| hypothetical protein TcasGA2_TC003502 [Tribolium castaneum] 687865299 LK927543.1 35 5.91805e-06 Caenorhabditis elegans genome assembly C_elegans_Bristol_N2_v1_5_4 ,scaffold CELN2_scaffold0000013 K14848 RRB1, GRWD1 ribosome assembly protein RRB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14848 Q9BQ67 1160 3.1e-125 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens GN=GRWD1 PE=1 SV=1 PF00400//PF01119//PF08676 WD domain, G-beta repeat//DNA mismatch repair protein, C-terminal domain//MutL C terminal dimerisation domain GO:0006298 mismatch repair GO:0005524//GO:0030983//GO:0005515 ATP binding//mismatched DNA binding//protein binding GO:0005634 nucleus KOG0302 Ribosome Assembly protein Cluster-8309.16199 BP_3 37.00 2.03 1171 332183937 AEE26197.1 1517 9.4e-166 farnesoic acid O-methyltransferase short isoform [Scylla paramamosain] 396582128 HQ587050.2 1153 0 Scylla paramamosain farnesoic acid O-methyltransferase short isoform mRNA, complete cds -- -- -- -- Q8IZJ3 204 6.9e-15 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 OS=Homo sapiens GN=CPAMD8 PE=1 SV=2 PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.16207 BP_3 641.84 14.99 2356 478256643 ENN76825.1 678 3.7e-68 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAM1 447 9.3e-43 Alpha-taxilin OS=Mus musculus GN=Txlna PE=2 SV=1 PF13851//PF01418//PF05336//PF09728 Growth-arrest specific micro-tubule binding//Helix-turn-helix domain, rpiR family//Domain of unknown function (DUF718)//Myosin-like coiled-coil protein GO:0006355//GO:0019299//GO:0048870 regulation of transcription, DNA-templated//rhamnose metabolic process//cell motility GO:0003700//GO:0016857//GO:0019905 transcription factor activity, sequence-specific DNA binding//racemase and epimerase activity, acting on carbohydrates and derivatives//syntaxin binding GO:0005737//GO:0031514//GO:0005667 cytoplasm//motile cilium//transcription factor complex KOG1850 Myosin-like coiled-coil protein Cluster-8309.1621 BP_3 3.00 0.35 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16212 BP_3 16.00 0.56 1666 795111413 XP_011882470.1 185 3.8e-11 PREDICTED: gastrula zinc finger protein XlCGF58.1-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7KQZ4 146 5.2e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16215 BP_3 180.29 5.92 1760 478263263 ENN81647.1 2130 1.2e-236 hypothetical protein YQE_01945, partial [Dendroctonus ponderosae] 805819936 XM_003707231.2 208 1.86826e-102 PREDICTED: Megachile rotundata peptidyl-prolyl cis-trans isomerase-like 2 (LOC100880954), mRNA K10598 PPIL2, CYC4, CHP60 peptidyl-prolyl cis-trans isomerase-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10598 Q9D787 1489 1.0e-163 Peptidyl-prolyl cis-trans isomerase-like 2 OS=Mus musculus GN=Ppil2 PE=1 SV=2 PF11789//PF00160 Zinc-finger of the MIZ type in Nse subunit//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0008270//GO:0003755 zinc ion binding//peptidyl-prolyl cis-trans isomerase activity -- -- KOG0883 Cyclophilin type, U box-containing peptidyl-prolyl cis-trans isomerase Cluster-8309.16216 BP_3 145.73 9.49 1032 570341948 AHE77372.1 494 3.5e-47 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 285 2.5e-24 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.16218 BP_3 4.00 0.52 660 642912272 XP_008200632.1 233 4.1e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16220 BP_3 42.49 0.36 5978 642924174 XP_008194038.1 2163 6.0e-240 PREDICTED: LOW QUALITY PROTEIN: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like [Tribolium castaneum] -- -- -- -- -- K05544 DUS3 tRNA-dihydrouridine synthase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05544 Q28BT8 1511 9.8e-166 tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Xenopus tropicalis GN=dus3l PE=2 SV=2 PF01207//PF00642 Dihydrouridine synthase (Dus)//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0008033//GO:0055114 tRNA processing//oxidation-reduction process GO:0046872//GO:0017150//GO:0050660 metal ion binding//tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG2333 Uncharacterized conserved protein Cluster-8309.16221 BP_3 362.07 2.62 6950 642921743 XP_008199309.1 1367 1.4e-147 PREDICTED: protein kinase C-binding protein 1 isoform X2 [Tribolium castaneum] 688610729 XM_009296665.1 57 6.52348e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 819 2.0e-85 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF00439//PF03832//PF00628 Bromodomain//WSK motif//PHD-finger GO:0006605//GO:0007165 protein targeting//signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.16223 BP_3 406.59 2.94 6966 642921743 XP_008199309.1 1367 1.4e-147 PREDICTED: protein kinase C-binding protein 1 isoform X2 [Tribolium castaneum] 688610729 XM_009296665.1 57 6.53858e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 819 2.0e-85 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF00439//PF00628//PF03832 Bromodomain//PHD-finger//WSK motif GO:0006605//GO:0007165 protein targeting//signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.16225 BP_3 100.15 0.85 6000 478257235 ENN77398.1 1108 1.3e-117 hypothetical protein YQE_06223, partial [Dendroctonus ponderosae] 688610729 XM_009296665.1 57 5.62972e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 643 4.4e-65 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF03832//PF00439 WSK motif//Bromodomain GO:0006605//GO:0007165 protein targeting//signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.16227 BP_3 13.00 0.62 1297 795264447 XP_011811659.1 1705 1.7e-187 PREDICTED: glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [Colobus angolensis palliatus] 9802301 AF261085.1 1254 0 AF261085 Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNA, complete cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q5RAB4 1719 1.6e-190 Glyceraldehyde-3-phosphate dehydrogenase OS=Pongo abelii GN=GAPDH PE=2 SV=3 PF00044//PF01113//PF02800 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Dihydrodipicolinate reductase, N-terminus//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0009085//GO:0055114//GO:0009089 lysine biosynthetic process//oxidation-reduction process//lysine biosynthetic process via diaminopimelate GO:0016620//GO:0008839 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//4-hydroxy-tetrahydrodipicolinate reductase -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.16229 BP_3 66.35 2.05 1853 820805536 AKG92759.1 682 1.0e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 2.83219e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 4.9e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF00010//PF01586 Helix-loop-helix DNA-binding domain//Myogenic Basic domain GO:0007517//GO:0006355 muscle organ development//regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.16230 BP_3 466.80 4.87 4916 91077028 XP_967318.1 1305 1.5e-140 PREDICTED: moesin/ezrin/radixin homolog 1 [Tribolium castaneum]>gi|270002017|gb|EEZ98464.1| hypothetical protein TcasGA2_TC000955 [Tribolium castaneum] -- -- -- -- -- K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 988 3.6e-105 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF00769//PF00551//PF02911//PF05531//PF00887 Ezrin/radixin/moesin family//Formyl transferase//Formyl transferase, C-terminal domain//Nucleopolyhedrovirus P10 protein//Acyl CoA binding protein GO:0009058 biosynthetic process GO:0000062//GO:0008092//GO:0016742 fatty-acyl-CoA binding//cytoskeletal protein binding//hydroxymethyl-, formyl- and related transferase activity GO:0019898//GO:0019028//GO:0005737 extrinsic component of membrane//viral capsid//cytoplasm KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.16232 BP_3 56.68 14.26 483 642923877 XP_008193910.1 513 1.0e-49 PREDICTED: aristaless isoform X1 [Tribolium castaneum] 543718138 XM_005500258.1 59 3.28683e-20 PREDICTED: Columba livia ALX homeobox 4 (ALX4), mRNA K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 Q06453 405 1.4e-38 Homeobox protein aristaless OS=Drosophila melanogaster GN=al PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.16239 BP_3 15.90 1.17 948 795014455 XP_011883890.1 227 2.9e-16 PREDICTED: uncharacterized protein LOC105571033 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16240 BP_3 3.00 0.42 633 641656303 XP_008179909.1 147 3.7e-07 PREDICTED: uncharacterized protein LOC103308399 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16246 BP_3 8.89 0.36 1473 91079056 XP_975139.1 583 2.4e-57 PREDICTED: uncharacterized protein LOC664025 [Tribolium castaneum]>gi|270004195|gb|EFA00643.1| hypothetical protein TcasGA2_TC003519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.16247 BP_3 38.75 2.73 977 642929783 XP_008195974.1 313 3.2e-26 PREDICTED: antifreeze protein Maxi-like [Tribolium castaneum]>gi|642929785|ref|XP_008195975.1| PREDICTED: antifreeze protein Maxi-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13851//PF04614//PF02970//PF04111//PF03153 Growth-arrest specific micro-tubule binding//Pex19 protein family//Tubulin binding cofactor A//Autophagy protein Apg6//Transcription factor IIA, alpha/beta subunit GO:0006914//GO:0048870//GO:0006367//GO:0007021 autophagy//cell motility//transcription initiation from RNA polymerase II promoter//tubulin complex assembly GO:0015631//GO:0051082 tubulin binding//unfolded protein binding GO:0005777//GO:0045298//GO:0031514//GO:0005672 peroxisome//tubulin complex//motile cilium//transcription factor TFIIA complex -- -- Cluster-8309.16248 BP_3 16003.25 1237.59 915 642929783 XP_008195974.1 313 3.0e-26 PREDICTED: antifreeze protein Maxi-like [Tribolium castaneum]>gi|642929785|ref|XP_008195975.1| PREDICTED: antifreeze protein Maxi-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02970//PF04111//PF03153//PF13851//PF04614 Tubulin binding cofactor A//Autophagy protein Apg6//Transcription factor IIA, alpha/beta subunit//Growth-arrest specific micro-tubule binding//Pex19 protein family GO:0006914//GO:0048870//GO:0006367//GO:0007021 autophagy//cell motility//transcription initiation from RNA polymerase II promoter//tubulin complex assembly GO:0015631//GO:0051082 tubulin binding//unfolded protein binding GO:0005777//GO:0045298//GO:0031514//GO:0005672 peroxisome//tubulin complex//motile cilium//transcription factor TFIIA complex -- -- Cluster-8309.16258 BP_3 245.47 4.39 2984 91094373 XP_970761.1 1832 7.2e-202 PREDICTED: COP9 signalosome complex subunit 3 [Tribolium castaneum]>gi|270014914|gb|EFA11362.1| hypothetical protein TcasGA2_TC011519 [Tribolium castaneum] -- -- -- -- -- K12177 COPS3, CSN3 COP9 signalosome complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12177 Q6P2U9 1279 3.9e-139 COP9 signalosome complex subunit 3 OS=Danio rerio GN=cops3 PE=2 SV=1 PF03791//PF01399 KNOX2 domain//PCI domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG2582 COP9 signalosome, subunit CSN3 Cluster-8309.16259 BP_3 13.96 0.43 1843 91082039 XP_970789.1 1573 4.8e-172 PREDICTED: integrator complex subunit 4 [Tribolium castaneum]>gi|270007301|gb|EFA03749.1| hypothetical protein TcasGA2_TC013858 [Tribolium castaneum] -- -- -- -- -- K13141 INTS4 integrator complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13141 Q8CIM8 798 1.4e-83 Integrator complex subunit 4 OS=Mus musculus GN=Ints4 PE=1 SV=1 PF02985//PF01602//PF11991 HEAT repeat//Adaptin N terminal region//Tryptophan dimethylallyltransferase GO:0016192//GO:0006886//GO:0009820 vesicle-mediated transport//intracellular protein transport//alkaloid metabolic process GO:0005515//GO:0050364 protein binding//tryptophan dimethylallyltransferase activity GO:0030117 membrane coat -- -- Cluster-8309.1626 BP_3 13.00 0.46 1657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16263 BP_3 325.15 4.86 3518 91082039 XP_970789.1 4010 0.0e+00 PREDICTED: integrator complex subunit 4 [Tribolium castaneum]>gi|270007301|gb|EFA03749.1| hypothetical protein TcasGA2_TC013858 [Tribolium castaneum] 751460794 XM_011186873.1 38 1.199e-07 PREDICTED: Bactrocera cucurbitae integrator complex subunit 4 (LOC105213804), mRNA K13141 INTS4 integrator complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13141 Q8CIM8 1700 7.0e-188 Integrator complex subunit 4 OS=Mus musculus GN=Ints4 PE=1 SV=1 PF01602//PF11991//PF02985 Adaptin N terminal region//Tryptophan dimethylallyltransferase//HEAT repeat GO:0009820//GO:0006886//GO:0016192 alkaloid metabolic process//intracellular protein transport//vesicle-mediated transport GO:0050364//GO:0005515 tryptophan dimethylallyltransferase activity//protein binding GO:0030117 membrane coat KOG2259 Uncharacterized conserved protein Cluster-8309.16268 BP_3 16.00 8.09 385 21667216 AAM73986.1 573 9.0e-57 alpha-tubulin 1 [Homarus gammarus] 2098752 U92646.1 286 1.66534e-146 GLU92646 Gecarcinus lateralis alpha-2-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q3ZCJ7 561 9.1e-57 Tubulin alpha-1C chain OS=Bos taurus GN=TUBA1C PE=1 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.1627 BP_3 2.99 0.91 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03857 Colicin immunity protein GO:0030153//GO:0006955 bacteriocin immunity//immune response GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.16271 BP_3 14.67 1.06 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.16273 BP_3 57.71 0.36 8065 642940402 XP_008200549.1 5160 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 752868301 XM_011252918.1 50 5.89792e-14 PREDICTED: Camponotus floridanus Down syndrome cell adhesion molecule-like protein Dscam2 (LOC105248250), mRNA -- -- -- -- Q9VS29 2484 2.0e-278 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05790//PF03824//PF00041//PF13895 Immunoglobulin C2-set domain//High-affinity nickel-transport protein//Fibronectin type III domain//Immunoglobulin domain GO:0015675//GO:0035444//GO:0007155 nickel cation transport//nickel cation transmembrane transport//cell adhesion GO:0046872//GO:0005515//GO:0015099 metal ion binding//protein binding//nickel cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.16278 BP_3 16.42 0.63 1553 332375989 AEE63135.1 933 6.5e-98 unknown [Dendroctonus ponderosae]>gi|478258650|gb|ENN78700.1| hypothetical protein YQE_04872, partial [Dendroctonus ponderosae] 645003560 XR_512750.1 69 3.0591e-25 PREDICTED: Nasonia vitripennis kidney mitochondrial carrier protein 1 (LOC100120159), transcript variant X2, misc_RNA K15106 SLC25A14_30 solute carrier family 25 (mitochondrial carrier), member 14/30 http://www.genome.jp/dbget-bin/www_bget?ko:K15106 O95258 596 3.2e-60 Brain mitochondrial carrier protein 1 OS=Homo sapiens GN=SLC25A14 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.1628 BP_3 5.00 0.39 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02815 MIR domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.16282 BP_3 81.00 5.06 1063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16294 BP_3 36.90 0.79 2546 827542484 XP_012544315.1 618 3.6e-61 PREDICTED: uncharacterized protein LOC105841373 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00218 Indole-3-glycerol phosphate synthase GO:0000162//GO:0006571//GO:0009094 tryptophan biosynthetic process//tyrosine biosynthetic process//L-phenylalanine biosynthetic process GO:0004425 indole-3-glycerol-phosphate synthase activity -- -- -- -- Cluster-8309.16295 BP_3 180.10 3.91 2513 827542484 XP_012544315.1 474 1.8e-44 PREDICTED: uncharacterized protein LOC105841373 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11093 Mitochondrial export protein Som1 -- -- -- -- GO:0042720 mitochondrial inner membrane peptidase complex -- -- Cluster-8309.16297 BP_3 297.40 4.17 3731 478251121 ENN71597.1 2722 5.6e-305 hypothetical protein YQE_11696, partial [Dendroctonus ponderosae] 543338846 XM_005516267.1 47 1.26338e-12 PREDICTED: Pseudopodoces humilis mitochondrial intermediate peptidase (MIPEP), mRNA K01410 MIPEP mitochondrial intermediate peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01410 Q99797 1823 4.1e-202 Mitochondrial intermediate peptidase OS=Homo sapiens GN=MIPEP PE=1 SV=2 PF01432//PF08533 Peptidase family M3//Beta-galactosidase C-terminal domain GO:0006687//GO:0046486//GO:0006508//GO:0006027//GO:0006012 glycosphingolipid metabolic process//glycerolipid metabolic process//proteolysis//glycosaminoglycan catabolic process//galactose metabolic process GO:0004222//GO:0004565 metalloendopeptidase activity//beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG2090 Metalloendopeptidase family - mitochondrial intermediate peptidase Cluster-8309.16298 BP_3 15.46 0.31 2732 -- -- -- -- -- 462346965 APGK01034099.1 201 2.27253e-98 Dendroctonus ponderosae Seq01034109, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16299 BP_3 233.00 7.45 1800 270012020 EFA08468.1 340 4.4e-29 hypothetical protein TcasGA2_TC006118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32P12 206 6.2e-15 Uncharacterized protein C17orf53 homolog OS=Mus musculus PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1630 BP_3 168.33 2.03 4281 642914825 XP_008194954.1 152 6.6e-07 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16302 BP_3 3.00 0.45 612 642939494 XP_008190865.1 328 3.7e-28 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0003824//GO:0043167 catalytic activity//ion binding -- -- -- -- Cluster-8309.16303 BP_3 3.00 2.48 344 642939494 XP_008190865.1 268 1.9e-21 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08793 122 6.5e-06 Xanthine dehydrogenase OS=Calliphora vicina GN=XDH PE=2 SV=1 -- -- -- -- GO:0016491//GO:0046872//GO:0051536 oxidoreductase activity//metal ion binding//iron-sulfur cluster binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.16305 BP_3 220.00 7.54 1698 91094009 XP_971372.1 981 1.9e-103 PREDICTED: probable palmitoyltransferase ZDHHC24 [Tribolium castaneum]>gi|270016169|gb|EFA12617.1| hypothetical protein TcasGA2_TC006858 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q6IR37 324 1.2e-28 Probable palmitoyltransferase ZDHHC24 OS=Mus musculus GN=Zdhhc24 PE=2 SV=2 PF01529//PF06703 DHHC palmitoyltransferase//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008270//GO:0008233//GO:0046872 zinc ion binding//peptidase activity//metal ion binding GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex KOG1311 DHHC-type Zn-finger proteins Cluster-8309.16306 BP_3 189.33 2.27 4307 91086991 XP_973570.1 1347 1.8e-145 PREDICTED: maspardin [Tribolium castaneum]>gi|270010508|gb|EFA06956.1| hypothetical protein TcasGA2_TC009913 [Tribolium castaneum] -- -- -- -- -- K19367 SPG21 maspardin http://www.genome.jp/dbget-bin/www_bget?ko:K19367 Q6PC62 932 9.8e-99 Maspardin OS=Danio rerio GN=spg21 PE=2 SV=1 PF13145//PF14736 PPIC-type PPIASE domain//Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418//GO:0016853 protein-N-terminal asparagine amidohydrolase activity//isomerase activity -- -- -- -- Cluster-8309.16308 BP_3 687.95 5.74 6065 91086723 XP_970869.1 1356 2.3e-146 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 1.60488e-08 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 757 2.7e-78 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF02535//PF05637 ZIP Zinc transporter//galactosyl transferase GMA12/MNN10 family GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0016757//GO:0046873 transferase activity, transferring glycosyl groups//metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2693 Putative zinc transporter Cluster-8309.16309 BP_3 91.79 1.98 2526 768443546 XP_011563593.1 1008 2.1e-106 PREDICTED: uncharacterized protein LOC105393516 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01527//PF04218//PF03184//PF05225 Transposase//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease//helix-turn-helix, Psq domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677//GO:0003676 transposase activity//DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.16313 BP_3 95.20 1.88 2726 642918316 XP_008191456.1 959 1.1e-100 PREDICTED: proline-, glutamic acid- and leucine-rich protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZL8 169 1.8e-10 Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens GN=PELP1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16316 BP_3 193.92 5.28 2061 91087945 XP_972135.1 1136 2.5e-121 PREDICTED: CUE domain-containing protein 2 [Tribolium castaneum]>gi|270011934|gb|EFA08382.1| hypothetical protein TcasGA2_TC006025 [Tribolium castaneum] 642930958 XM_967042.2 295 9.51161e-151 PREDICTED: Tribolium castaneum CUE domain-containing protein 2 (LOC660839), mRNA -- -- -- -- Q6TLH3 407 3.5e-38 CUE domain-containing protein 2 OS=Danio rerio GN=cuedc2 PE=2 SV=1 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.16317 BP_3 105.00 4.29 1471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1632 BP_3 10.00 2.38 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16321 BP_3 95.64 1.64 3108 270010378 EFA06826.1 2294 2.0e-255 hypothetical protein TcasGA2_TC009768 [Tribolium castaneum] 642928761 XM_008201551.1 820 0 PREDICTED: Tribolium castaneum nephrin (LOC663236), mRNA -- -- -- -- Q9R044 217 5.7e-16 Nephrin OS=Rattus norvegicus GN=Nphs1 PE=1 SV=2 PF00041//PF04850//PF13895 Fibronectin type III domain//Baculovirus E66 occlusion-derived virus envelope protein//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0019031 viral envelope -- -- Cluster-8309.16322 BP_3 99.13 6.74 1001 91080431 XP_968599.1 343 1.1e-29 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16324 BP_3 23.26 1.14 1273 91080431 XP_968599.1 343 1.4e-29 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16327 BP_3 183.24 3.21 3041 642918448 XP_008191479.1 1481 3.7e-161 PREDICTED: probable deoxyhypusine synthase [Tribolium castaneum]>gi|270003242|gb|EEZ99689.1| hypothetical protein TcasGA2_TC002446 [Tribolium castaneum] 769838188 XM_011631947.1 151 1.57936e-70 PREDICTED: Pogonomyrmex barbatus probable deoxyhypusine synthase (LOC105422536), transcript variant X6, mRNA K00809 DHPS, dys deoxyhypusine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00809 Q9VSF4 1242 7.8e-135 Probable deoxyhypusine synthase OS=Drosophila melanogaster GN=CG8005 PE=2 SV=2 PF01916//PF03792 Deoxyhypusine synthase//PBC domain GO:0008612 peptidyl-lysine modification to peptidyl-hypusine GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG2924 Deoxyhypusine synthase Cluster-8309.16328 BP_3 11.58 0.61 1207 642919571 XP_008191927.1 497 1.8e-47 PREDICTED: protein angel isoform X2 [Tribolium castaneum] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q5VTE6 234 2.4e-18 Protein angel homolog 2 OS=Homo sapiens GN=ANGEL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2338 Transcriptional effector CCR4-related protein Cluster-8309.16329 BP_3 2.00 11.45 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16336 BP_3 9.00 1.03 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16337 BP_3 4.21 0.37 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16338 BP_3 32.00 1.17 1614 642920550 XP_008192401.1 367 2.9e-32 PREDICTED: uncharacterized protein LOC103312744 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1634 BP_3 14307.00 831.57 1121 478258430 ENN78523.1 145 1.1e-06 hypothetical protein YQE_05008, partial [Dendroctonus ponderosae] 156553235 XM_001599402.1 167 7.29102e-80 PREDICTED: Nasonia vitripennis histidine-rich glycoprotein (LOC100114425), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16341 BP_3 31.00 1.63 1207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16342 BP_3 11.00 1.94 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16343 BP_3 2.00 0.59 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16344 BP_3 43.40 0.65 3528 780089478 XP_011673857.1 145 3.5e-06 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02935//PF10104 Cytochrome c oxidase subunit VIIc//Di-sulfide bridge nucleocytoplasmic transport domain GO:0006406//GO:0006611//GO:0006998//GO:0006123//GO:0015992 mRNA export from nucleus//protein export from nucleus//nuclear envelope organization//mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0031965//GO:0045277 nuclear membrane//respiratory chain complex IV -- -- Cluster-8309.16345 BP_3 48.03 2.70 1148 546683414 ERL93230.1 345 7.4e-30 hypothetical protein D910_10526 [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 302 2.9e-26 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16346 BP_3 5.80 0.37 1042 478250613 ENN71105.1 859 1.7e-89 hypothetical protein YQE_12038, partial [Dendroctonus ponderosae]>gi|546673107|gb|ERL84776.1| hypothetical protein D910_02201 [Dendroctonus ponderosae] -- -- -- -- -- K06058 DTX deltex http://www.genome.jp/dbget-bin/www_bget?ko:K06058 Q23985 535 2.6e-53 Protein deltex OS=Drosophila melanogaster GN=dx PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16347 BP_3 639.29 6.39 5113 642938541 XP_008199834.1 1798 1.1e-197 PREDICTED: transcription factor Ken isoform X1 [Tribolium castaneum]>gi|270015579|gb|EFA12027.1| hypothetical protein TcasGA2_TC001442 [Tribolium castaneum] 642938542 XM_008201613.1 75 4.72511e-28 PREDICTED: Tribolium castaneum transcription factor Ken (LOC656389), transcript variant X2, mRNA -- -- -- -- Q292R5 588 9.0e-59 Transcription factor Ken OS=Drosophila pseudoobscura pseudoobscura GN=ken PE=3 SV=2 PF13465//PF00096//PF00651//PF00081//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//BTB/POZ domain//Iron/manganese superoxide dismutases, alpha-hairpin domain//C2H2-type zinc finger GO:0006801//GO:0055114 superoxide metabolic process//oxidation-reduction process GO:0003676//GO:0008270//GO:0046872//GO:0004784//GO:0005515 nucleic acid binding//zinc ion binding//metal ion binding//superoxide dismutase activity//protein binding GO:0005634 nucleus -- -- Cluster-8309.16348 BP_3 448.84 5.50 4225 642938541 XP_008199834.1 2342 7.4e-261 PREDICTED: transcription factor Ken isoform X1 [Tribolium castaneum]>gi|270015579|gb|EFA12027.1| hypothetical protein TcasGA2_TC001442 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q292R5 588 7.4e-59 Transcription factor Ken OS=Drosophila pseudoobscura pseudoobscura GN=ken PE=3 SV=2 PF00096//PF13465//PF04931//PF00651//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//DNA polymerase phi//BTB/POZ domain//C2H2-type zinc finger GO:0006351//GO:0006260 transcription, DNA-templated//DNA replication GO:0003677//GO:0005515//GO:0003887//GO:0003676//GO:0008270//GO:0046872 DNA binding//protein binding//DNA-directed DNA polymerase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634//GO:0042575 nucleus//DNA polymerase complex -- -- Cluster-8309.16349 BP_3 256.61 11.74 1345 91087239 XP_975511.1 728 3.3e-74 PREDICTED: eukaryotic initiation factor 4A-III [Tribolium castaneum]>gi|270010579|gb|EFA07027.1| hypothetical protein TcasGA2_TC009998 [Tribolium castaneum] 642929692 XM_970418.2 181 1.44923e-87 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4A-III (LOC664411), mRNA K13025 EIF4A3, FAL1 ATP-dependent RNA helicase http://www.genome.jp/dbget-bin/www_bget?ko:K13025 Q9VHS8 679 6.6e-70 Eukaryotic initiation factor 4A-III OS=Drosophila melanogaster GN=eIF4AIII PE=1 SV=1 PF04851//PF00580//PF00270 Type III restriction enzyme, res subunit//UvrD/REP helicase N-terminal domain//DEAD/DEAH box helicase -- -- GO:0016787//GO:0003677//GO:0003676//GO:0005524//GO:0008026 hydrolase activity//DNA binding//nucleic acid binding//ATP binding//ATP-dependent helicase activity -- -- KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily Cluster-8309.1635 BP_3 3404.00 1721.36 385 270006278 EFA02726.1 141 1.1e-06 hypothetical protein TcasGA2_TC008451 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.16352 BP_3 113.00 3.48 1856 270004106 EFA00554.1 897 1.2e-93 hypothetical protein TcasGA2_TC003421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R5F9 230 1.1e-17 ATP synthase subunit s-like protein OS=Macaca fascicularis GN=ATP5SL PE=2 SV=1 PF00560 Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG3864 Uncharacterized conserved protein Cluster-8309.1636 BP_3 10.35 1.65 594 270004761 EFA01209.1 458 3.0e-43 hypothetical protein TcasGA2_TC010536 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16360 BP_3 331.03 5.90 2996 189240717 XP_974290.2 956 2.7e-100 PREDICTED: polycomb group protein Pc isoform X3 [Tribolium castaneum]>gi|270014283|gb|EFA10731.1| polycomb [Tribolium castaneum] -- -- -- -- -- K11453 CBX6 chromobox protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11453 P26017 292 1.1e-24 Polycomb group protein Pc OS=Drosophila melanogaster GN=Pc PE=1 SV=1 PF00437 Type II/IV secretion system protein GO:0006810 transport GO:0005524 ATP binding -- -- KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.16362 BP_3 27.92 0.39 3703 332376975 AEE63627.1 1501 2.1e-163 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 141 6.981e-65 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1367 3.0e-149 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF04545//PF02984//PF01857//PF00382 Sigma-70, region 4//Cyclin, C-terminal domain//Retinoblastoma-associated protein B domain//Transcription factor TFIIB repeat GO:0051726//GO:0006352//GO:0006355 regulation of cell cycle//DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0017025//GO:0016987 DNA binding//transcription factor activity, sequence-specific DNA binding//TBP-class protein binding//sigma factor activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1597 Transcription initiation factor TFIIB Cluster-8309.16370 BP_3 28.41 0.79 2015 546676100 ERL87167.1 1869 2.5e-206 hypothetical protein D910_04567 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H267 394 1.1e-36 Vacuolar protein sorting-associated protein 33B OS=Homo sapiens GN=VPS33B PE=1 SV=2 PF08926//PF00995 Domain of unknown function (DUF1908)//Sec1 family GO:0016192//GO:0016310//GO:0006904//GO:0009069//GO:0006468 vesicle-mediated transport//phosphorylation//vesicle docking involved in exocytosis//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0000287//GO:0004674 ATP binding//magnesium ion binding//protein serine/threonine kinase activity -- -- KOG1302 Vacuolar sorting protein VPS33/slp1 (Sec1 family) Cluster-8309.16374 BP_3 16.25 0.34 2570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16378 BP_3 13.15 0.44 1730 91095049 XP_972102.1 649 6.2e-65 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 339 2.3e-30 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16379 BP_3 35.27 0.87 2255 91095049 XP_972102.1 649 8.1e-65 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 339 3.0e-30 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16380 BP_3 4.48 0.40 829 642916794 XP_008199506.1 589 2.7e-58 PREDICTED: transmembrane protein 70 homolog, mitochondrial [Tribolium castaneum]>gi|270003058|gb|EEZ99505.1| hypothetical protein TcasGA2_TC000082 [Tribolium castaneum] -- -- -- -- -- K17966 TMEM70 transmembrane protein 70, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17966 Q95SS8 390 1.3e-36 Transmembrane protein 70 homolog, mitochondrial OS=Drosophila melanogaster GN=CG7506 PE=2 SV=1 PF03977 Na+-transporting oxaloacetate decarboxylase beta subunit GO:0006814 sodium ion transport GO:0016829 lyase activity -- -- -- -- Cluster-8309.16384 BP_3 63.07 1.95 1849 546684929 ERL94511.1 220 3.7e-15 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.16385 BP_3 49.00 1.84 1578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16387 BP_3 88.02 2.46 2018 270297210 NP_001161910.1 334 2.4e-28 cuticular protein analogous to peritrophins 3-A1 precursor [Tribolium castaneum]>gi|268309018|gb|ACY95475.1| cuticular protein analogous to peritrophins 3-A1 [Tribolium castaneum]>gi|270000882|gb|EEZ97329.1| hypothetical protein TcasGA2_TC011140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.16388 BP_3 45.00 1.87 1450 751233858 XP_011170631.1 441 6.9e-41 PREDICTED: uncharacterized protein LOC105203526 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1639 BP_3 40.00 0.57 3648 642916432 XP_008191024.1 4277 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12024 851 2.0e-89 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.16393 BP_3 116.22 7.88 1003 573890433 XP_006632978.1 296 3.1e-24 PREDICTED: tyrosine-protein kinase BTK-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- P27446 274 4.5e-23 Tyrosine-protein kinase Fyn OS=Xiphophorus helleri GN=fyn PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.16395 BP_3 33.79 5.02 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16396 BP_3 2.00 0.54 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16398 BP_3 142.50 0.80 8885 270014787 EFA11235.1 3356 0.0e+00 hypothetical protein TcasGA2_TC010767 [Tribolium castaneum] 642911510 XM_008201231.1 266 5.48527e-134 PREDICTED: Tribolium castaneum protein unc-79 homolog (LOC662785), mRNA -- -- -- -- Q0KK59 1245 1.0e-134 Protein unc-79 homolog OS=Mus musculus GN=Unc79 PE=1 SV=1 PF08689 Mediator complex subunit Med5 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4820 Involved in anesthetic response in C.elegans Cluster-8309.16399 BP_3 242.74 3.59 3552 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.7e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.164 BP_3 8.48 0.71 869 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1640 BP_3 34.00 1.49 1394 736215480 XP_010778437.1 304 5.1e-25 PREDICTED: aquaporin-3-like [Notothenia coriiceps] 768311758 CP010986.1 1372 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence K09877 AQP9 aquaporin-9 http://www.genome.jp/dbget-bin/www_bget?ko:K09877 Q92482 268 3.1e-22 Aquaporin-3 OS=Homo sapiens GN=AQP3 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0224 Aquaporin (major intrinsic protein family) Cluster-8309.16400 BP_3 7.76 1.16 615 642923172 XP_008193639.1 525 5.3e-51 PREDICTED: protein archease-like [Tribolium castaneum]>gi|270007591|gb|EFA04039.1| hypothetical protein TcasGA2_TC014269 [Tribolium castaneum] 847100090 XM_012956998.1 41 4.30278e-10 PREDICTED: Xenopus (Silurana) tropicalis zinc finger and BTB domain containing 8 opposite strand (zbtb8os), transcript variant X1, mRNA -- -- -- -- Q9VD92 408 8.1e-39 Protein archease-like OS=Drosophila melanogaster GN=CG6353 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4528 Uncharacterized conserved protein Cluster-8309.16401 BP_3 10.00 0.35 1654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16405 BP_3 1786.61 16.44 5531 642918480 XP_008191494.1 5359 0.0e+00 PREDICTED: epidermal growth factor receptor isoform X2 [Tribolium castaneum] -- -- -- -- -- K04361 EGFR, ERBB1 epidermal growth factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04361 P0CY46 4398 0.0e+00 Epidermal growth factor receptor OS=Apis mellifera GN=Egfr PE=2 SV=1 PF00757//PF00069//PF06293//PF07714 Furin-like cysteine rich region//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0016773//GO:0004714//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//transmembrane receptor protein tyrosine kinase activity//protein kinase activity GO:0016020 membrane KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-8309.1641 BP_3 42.00 0.67 3321 478530031 XP_004439183.1 181 2.2e-10 PREDICTED: zinc finger protein 135 [Ceratotherium simum simum] 768311752 CP010980.1 2233 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K09208 KLF9S, BTEB krueppel-like factor 9/13/14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K09208 Q4V8A8 176 3.5e-11 Zinc finger protein 90 OS=Rattus norvegicus GN=Zfp90 PE=2 SV=1 PF13465//PF00096//PF13912//PF02892//PF16622//PF01200 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//Ribosomal protein S28e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003677//GO:0003735//GO:0046872 DNA binding//structural constituent of ribosome//metal ion binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.16410 BP_3 25.00 0.92 1606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16411 BP_3 1.00 1.14 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16413 BP_3 2.00 0.95 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16415 BP_3 242.88 4.29 3018 795017716 XP_011858948.1 1092 4.7e-116 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105556466 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16416 BP_3 17.27 2.39 640 642937130 XP_008198705.1 178 9.5e-11 PREDICTED: short neuropeptide F-like [Tribolium castaneum]>gi|270001316|gb|EEZ97763.1| short neuropeptide F [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1642 BP_3 137.00 6.93 1244 -- -- -- -- -- 697073026 XM_009652962.1 1238 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- Q01302 129 3.7e-06 Clock-controlled protein 6 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=ccg-6 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16429 BP_3 549.31 6.02 4691 642934488 XP_008197685.1 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934490|ref|XP_008197686.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934492|ref|XP_008197687.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|270013516|gb|EFA09964.1| hypothetical protein TcasGA2_TC012121 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54316 599 4.4e-60 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 -- -- -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.1643 BP_3 25.00 0.69 2031 556764024 XP_005977290.1 517 1.5e-49 PREDICTED: amino-acid permease inda1-like [Pantholops hodgsonii] 697090107 XM_009659665.1 1792 0 Verticillium dahliae VdLs.17 amino-acid permease inda1 partial mRNA -- -- -- -- P34054 1514 1.5e-166 Amino-acid permease inda1 OS=Hypocrea atroviridis GN=inda1 PE=2 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0006865//GO:0055085//GO:0003333//GO:0006810 amino acid transport//transmembrane transport//amino acid transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.16430 BP_3 20.22 0.33 3216 328701369 XP_003241578.1 565 6.4e-55 PREDICTED: KRAB-A domain-containing protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6R2W3 495 3.4e-48 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 PF06184//PF00665 Potexvirus coat protein//Integrase core domain GO:0015074 DNA integration GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.16432 BP_3 24.66 2.49 770 642937482 XP_008198857.1 257 7.9e-20 PREDICTED: protein tramtrack, beta isoform-like isoform X18 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16434 BP_3 5.21 0.64 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16435 BP_3 7.03 0.49 986 91079786 XP_967971.1 1104 6.2e-118 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 857 1.1e-90 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 -- -- GO:0042254//GO:0006396 ribosome biogenesis//RNA processing GO:0003824 catalytic activity GO:0005730 nucleolus KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.16437 BP_3 177.00 5.02 1990 642913935 XP_008201220.1 1315 4.2e-142 PREDICTED: nucleoporin NDC1 isoform X1 [Tribolium castaneum]>gi|642913937|ref|XP_008201221.1| PREDICTED: nucleoporin NDC1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q298S5 410 1.5e-38 Nucleoporin Ndc1 OS=Drosophila pseudoobscura pseudoobscura GN=Ndc1 PE=3 SV=1 PF08710 nsp9 replicase GO:0019079 viral genome replication GO:0003723 RNA binding -- -- KOG4358 Uncharacterized conserved protein Cluster-8309.16439 BP_3 11.00 0.55 1254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.1644 BP_3 21.00 0.38 2927 694531325 XP_009494135.1 361 2.6e-31 CAMK/CAMKL protein kinase [Fonticula alba]>gi|627949148|gb|KCV71012.1| CAMK/CAMKL protein kinase [Fonticula alba] 768311757 CP010985.1 1784 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 P08092 728 3.0e-75 Negative regulator of sexual conjugation and meiosis OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ran1 PE=1 SV=2 PF07714//PF00069//PF06293//PF04261 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Dyp-type peroxidase family GO:0055114//GO:0006468//GO:0006804//GO:0006979 oxidation-reduction process//protein phosphorylation//obsolete peroxidase reaction//response to oxidative stress GO:0020037//GO:0004672//GO:0016773//GO:0004601//GO:0005524 heme binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//peroxidase activity//ATP binding GO:0016020 membrane KOG0583 Serine/threonine protein kinase Cluster-8309.16442 BP_3 483.15 11.79 2267 817054390 XP_012267339.1 1888 1.7e-208 PREDICTED: organic cation transporter protein-like [Athalia rosae] 815793565 XM_012361984.1 64 2.70708e-22 PREDICTED: Linepithema humile uncharacterized LOC105669183 (LOC105669183), mRNA -- -- -- -- Q9Y226 614 3.8e-62 Solute carrier family 22 member 13 OS=Homo sapiens GN=SLC22A13 PE=2 SV=2 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.16448 BP_3 4.00 0.97 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16451 BP_3 169.00 7.81 1335 478260192 ENN79965.1 695 2.2e-70 hypothetical protein YQE_03611, partial [Dendroctonus ponderosae] -- -- -- -- -- K13248 PHOSPHO2 pyridoxal phosphate phosphatase PHOSPHO2 http://www.genome.jp/dbget-bin/www_bget?ko:K13248 Q66KD6 401 1.1e-37 Probable phosphatase phospho2 OS=Xenopus tropicalis GN=phospho2 PE=2 SV=1 PF02358//PF06888 Trehalose-phosphatase//Putative Phosphatase GO:0008152//GO:0005992 metabolic process//trehalose biosynthetic process GO:0003824//GO:0016791 catalytic activity//phosphatase activity -- -- KOG3120 Predicted haloacid dehalogenase-like hydrolase Cluster-8309.16452 BP_3 2.00 0.35 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16456 BP_3 12.00 0.91 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16457 BP_3 38.87 0.80 2636 478253165 ENN73536.1 328 1.6e-27 hypothetical protein YQE_09787, partial [Dendroctonus ponderosae] 462304277 APGK01049550.1 97 1.42675e-40 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q7KQZ4 197 1.0e-13 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.16458 BP_3 18.96 0.37 2766 546678918 ERL89456.1 328 1.7e-27 hypothetical protein D910_06823 [Dendroctonus ponderosae] 462304277 APGK01049550.1 97 1.49704e-40 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q7KQZ4 197 1.1e-13 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1646 BP_3 3.00 1.78 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16462 BP_3 579.47 14.58 2208 478263841 ENN82073.1 328 1.3e-27 hypothetical protein YQE_01549, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16469 BP_3 480.54 9.61 2702 91091782 XP_969684.1 2845 0.0e+00 PREDICTED: cell division cycle 5-like protein [Tribolium castaneum]>gi|270001087|gb|EEZ97534.1| hypothetical protein TcasGA2_TC011382 [Tribolium castaneum] 807017652 XM_004518985.2 277 1.26906e-140 PREDICTED: Ceratitis capitata cell division cycle 5-like protein (LOC101451004), mRNA K12860 CDC5L, CDC5, CEF1 pre-mRNA-splicing factor CDC5/CEF1 http://www.genome.jp/dbget-bin/www_bget?ko:K12860 O08837 2223 1.2e-248 Cell division cycle 5-like protein OS=Rattus norvegicus GN=Cdc5l PE=1 SV=2 PF08702 Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0030168 protein polymerization//signal transduction//platelet activation GO:0030674//GO:0005488//GO:0005102 protein binding, bridging//binding//receptor binding GO:0005577 fibrinogen complex KOG0050 mRNA splicing protein CDC5 (Myb superfamily) Cluster-8309.16472 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16478 BP_3 5.84 2.71 394 642931489 XP_008196607.1 533 4.0e-52 PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931491|ref|XP_967441.2| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931493|ref|XP_008196608.1| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9U9 301 1.3e-26 Nitrogen permease regulator 2-like protein OS=Bos taurus GN=NPRL2 PE=2 SV=1 PF03584 Herpesvirus ICP4-like protein N-terminal region GO:0045893 positive regulation of transcription, DNA-templated -- -- GO:0042025 host cell nucleus KOG3789 Nitrogen permease regulator NLRG/NPR2 Cluster-8309.16479 BP_3 53.91 1.36 2203 642920972 XP_008192636.1 240 2.1e-17 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1648 BP_3 6.70 0.33 1279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16481 BP_3 73.00 1.98 2072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06839 GRF zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.16483 BP_3 3.00 0.46 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16486 BP_3 239.48 4.08 3119 478256280 ENN76470.1 950 1.4e-99 hypothetical protein YQE_06924, partial [Dendroctonus ponderosae] 488547849 XM_004465365.1 61 1.73914e-20 PREDICTED: Dasypus novemcinctus SYF2 pre-mRNA-splicing factor (SYF2), mRNA K12868 SYF2 pre-mRNA-splicing factor SYF2 http://www.genome.jp/dbget-bin/www_bget?ko:K12868 Q28XK6 748 1.5e-77 Pre-mRNA-splicing factor Syf2 OS=Drosophila pseudoobscura pseudoobscura GN=Syf2 PE=3 SV=1 PF06839//PF03079//PF01529//PF03405//PF00199//PF10237//PF00098 GRF zinc finger//ARD/ARD' family//DHHC palmitoyltransferase//Fatty acid desaturase//Catalase//Probable N6-adenine methyltransferase//Zinc knuckle GO:0015947//GO:0006979//GO:0006804//GO:0006568//GO:0006631//GO:0055114 methane metabolic process//response to oxidative stress//obsolete peroxidase reaction//tryptophan metabolic process//fatty acid metabolic process//oxidation-reduction process GO:0010309//GO:0045300//GO:0004096//GO:0003676//GO:0008168//GO:0008270//GO:0020037 acireductone dioxygenase [iron(II)-requiring] activity//acyl-[acyl-carrier-protein] desaturase activity//catalase activity//nucleic acid binding//methyltransferase activity//zinc ion binding//heme binding -- -- KOG2609 Cyclin D-interacting protein GCIP Cluster-8309.16487 BP_3 269.52 4.69 3059 478257683 ENN77830.1 1530 7.7e-167 hypothetical protein YQE_05713, partial [Dendroctonus ponderosae] 488547849 XM_004465365.1 61 1.7053e-20 PREDICTED: Dasypus novemcinctus SYF2 pre-mRNA-splicing factor (SYF2), mRNA -- -- -- -- Q9H5U6 966 7.9e-103 Zinc finger CCHC domain-containing protein 4 OS=Homo sapiens GN=ZCCHC4 PE=1 SV=3 PF03079//PF06839//PF00098//PF10237//PF01529//PF00199 ARD/ARD' family//GRF zinc finger//Zinc knuckle//Probable N6-adenine methyltransferase//DHHC palmitoyltransferase//Catalase GO:0006568//GO:0055114//GO:0015947//GO:0006979//GO:0006804 tryptophan metabolic process//oxidation-reduction process//methane metabolic process//response to oxidative stress//obsolete peroxidase reaction GO:0003676//GO:0008270//GO:0008168//GO:0020037//GO:0010309//GO:0004096 nucleic acid binding//zinc ion binding//methyltransferase activity//heme binding//acireductone dioxygenase [iron(II)-requiring] activity//catalase activity -- -- KOG2609 Cyclin D-interacting protein GCIP Cluster-8309.16488 BP_3 12.00 0.35 1955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16489 BP_3 9.00 0.42 1322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03485 Arginyl tRNA synthetase N terminal domain GO:0006560//GO:0006420//GO:0006525 proline metabolic process//arginyl-tRNA aminoacylation//arginine metabolic process GO:0004814//GO:0005524//GO:0000166 arginine-tRNA ligase activity//ATP binding//nucleotide binding GO:0005737 cytoplasm -- -- Cluster-8309.16495 BP_3 348.45 5.17 3543 642919497 XP_008191896.1 2771 1.1e-310 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.16498 BP_3 6.00 1.59 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.165 BP_3 8.00 0.68 859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1650 BP_3 14.00 0.68 1281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16500 BP_3 33.32 0.66 2734 642925371 XP_008194521.1 312 1.2e-25 PREDICTED: zinc finger protein 600-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 222 1.3e-16 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF04988//PF13465//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.16503 BP_3 17.82 0.38 2573 332375488 AEE62885.1 924 1.2e-96 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02089 CDK4 cyclin-dependent kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02089 Q91727 680 9.7e-70 Cyclin-dependent kinase 4 OS=Xenopus laevis GN=cdk4 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.16507 BP_3 56.31 2.73 1285 546673280 ERL84916.1 258 1.0e-19 hypothetical protein D910_02339 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.16509 BP_3 889.86 21.92 2248 189236049 XP_001809395.1 699 1.3e-70 PREDICTED: tudor domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- K18404 TDRD3 tudor domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18404 Q5ZMS6 412 1.0e-38 Tudor domain-containing protein 3 OS=Gallus gallus GN=TDRD3 PE=2 SV=1 PF06003//PF09103 Survival motor neuron protein (SMN)//BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 GO:0000724//GO:0006397 double-strand break repair via homologous recombination//mRNA processing GO:0003723 RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG3683 Uncharacterized conserved protein Cluster-8309.16513 BP_3 1.40 0.39 466 4530036 AAD21827.1 154 4.2e-08 chymotrypsin-like serine protease [Ctenocephalides felis] -- -- -- -- -- -- -- -- -- Q9Y5K2 124 5.2e-06 Kallikrein-4 OS=Homo sapiens GN=KLK4 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.16514 BP_3 2.12 0.48 502 15420657 AAK97411.1 218 1.7e-15 serine protease-like protein [Anthonomus grandis] -- -- -- -- -- -- -- -- -- Q3UP87 150 5.4e-09 Neutrophil elastase OS=Mus musculus GN=Elane PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.16515 BP_3 2.00 9.74 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16516 BP_3 9.00 0.65 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1652 BP_3 3.00 0.62 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.16520 BP_3 17.46 0.81 1326 642912029 XP_008199066.1 1100 2.4e-117 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 270 1.7e-22 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF02460//PF03176//PF00873 Patched family//MMPL family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.16525 BP_3 62.09 0.97 3376 332374404 AEE62343.1 777 1.7e-79 unknown [Dendroctonus ponderosae] -- -- -- -- -- K07071 K07071 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K07071 Q17QH8 502 5.6e-49 Epimerase family protein SDR39U1 OS=Bos taurus GN=SDR39U1 PE=2 SV=1 PF00070//PF00705//PF07650//PF01370//PF03184 Pyridine nucleotide-disulphide oxidoreductase//Proliferating cell nuclear antigen, N-terminal domain//KH domain//NAD dependent epimerase/dehydratase family//DDE superfamily endonuclease GO:0006275//GO:0055114 regulation of DNA replication//oxidation-reduction process GO:0050662//GO:0003824//GO:0003723//GO:0003677//GO:0016491//GO:0003676 coenzyme binding//catalytic activity//RNA binding//DNA binding//oxidoreductase activity//nucleic acid binding -- -- KOG3019 Predicted nucleoside-diphosphate sugar epimerase Cluster-8309.16527 BP_3 24.00 1.17 1278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16528 BP_3 152.04 11.72 917 642925157 XP_967086.2 712 1.6e-72 PREDICTED: DNA-directed RNA polymerase II subunit RPB9 [Tribolium castaneum] 751463391 XM_011188291.1 154 9.98113e-73 PREDICTED: Bactrocera cucurbitae DNA-directed RNA polymerase II subunit RPB9 (LOC105214718), mRNA K03017 RPB9, POLR2I DNA-directed RNA polymerase II subunit RPB9 http://www.genome.jp/dbget-bin/www_bget?ko:K03017 P36958 633 9.7e-65 DNA-directed RNA polymerase II subunit RPB9 OS=Drosophila melanogaster GN=RpII15 PE=2 SV=2 PF01396//PF00130//PF01667//PF02150//PF01096 Topoisomerase DNA binding C4 zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ribosomal protein S27//RNA polymerases M/15 Kd subunit//Transcription factor S-II (TFIIS) GO:0042254//GO:0035556//GO:0006265//GO:0006206//GO:0006144//GO:0006412//GO:0006351 ribosome biogenesis//intracellular signal transduction//DNA topological change//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//translation//transcription, DNA-templated GO:0008270//GO:0003735//GO:0003899//GO:0003676//GO:0003916//GO:0003677 zinc ion binding//structural constituent of ribosome//DNA-directed RNA polymerase activity//nucleic acid binding//DNA topoisomerase activity//DNA binding GO:0005730//GO:0005840//GO:0005622//GO:0005694 nucleolus//ribosome//intracellular//chromosome KOG2691 RNA polymerase II subunit 9 Cluster-8309.16530 BP_3 6.00 0.45 941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16531 BP_3 36.57 1.08 1924 189238895 XP_966473.2 663 1.6e-66 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 9.0e-28 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF13855//PF00128 Leucine rich repeat//Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169//GO:0005515 catalytic activity//cation binding//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.16537 BP_3 13.00 0.80 1074 546682957 ERL92836.1 201 3.4e-13 hypothetical protein D910_10143 [Dendroctonus ponderosae] -- -- -- -- -- K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 196 5.4e-14 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.16538 BP_3 35.05 1.47 1440 332373478 AEE61880.1 814 3.8e-84 unknown [Dendroctonus ponderosae]>gi|478263741|gb|ENN82044.1| hypothetical protein YQE_01619, partial [Dendroctonus ponderosae]>gi|546670972|gb|ERL83504.1| hypothetical protein D910_00535 [Dendroctonus ponderosae]>gi|546679616|gb|ERL90053.1| hypothetical protein D910_07409 [Dendroctonus ponderosae] -- -- -- -- -- K00949 thiN, TPK1, THI80 thiamine pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00949 Q9H3S4 487 1.3e-47 Thiamin pyrophosphokinase 1 OS=Homo sapiens GN=TPK1 PE=1 SV=1 PF04263//PF04265//PF01341 Thiamin pyrophosphokinase, catalytic domain//Thiamin pyrophosphokinase, vitamin B1 binding domain//Glycosyl hydrolases family 6 GO:0030245//GO:0005975//GO:0009229//GO:0006772 cellulose catabolic process//carbohydrate metabolic process//thiamine diphosphate biosynthetic process//thiamine metabolic process GO:0030975//GO:0004788//GO:0005524//GO:0004553 thiamine binding//thiamine diphosphokinase activity//ATP binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG3153 Thiamine pyrophosphokinase Cluster-8309.16540 BP_3 100.50 1.90 2836 270015294 EFA11742.1 1592 4.6e-174 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.16541 BP_3 18.19 1.03 1139 642917151 XP_008191139.1 470 2.3e-44 PREDICTED: F-box-like/WD repeat-containing protein TBL1XR1 [Tribolium castaneum]>gi|270004371|gb|EFA00819.1| hypothetical protein TcasGA2_TC003706 [Tribolium castaneum] -- -- -- -- -- K04508 TBL1 transducin (beta)-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04508 O60907 389 2.4e-36 F-box-like/WD repeat-containing protein TBL1X OS=Homo sapiens GN=TBL1X PE=1 SV=3 PF00400//PF03936//PF08513 WD domain, G-beta repeat//Terpene synthase family, metal binding domain//LisH -- -- GO:0016829//GO:0005515//GO:0000287//GO:0010333 lyase activity//protein binding//magnesium ion binding//terpene synthase activity -- -- KOG0273 Beta-transducin family (WD-40 repeat) protein Cluster-8309.16545 BP_3 1.00 0.96 334 642925814 XP_970128.3 327 2.6e-28 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 205 1.5e-15 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01073//PF05531//PF00106//PF01370//PF12242 3-beta hydroxysteroid dehydrogenase/isomerase family//Nucleopolyhedrovirus P10 protein//short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008210//GO:0008152//GO:0008209//GO:0055114//GO:0006694//GO:0008207 estrogen metabolic process//metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0003824//GO:0050662//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0019028 viral capsid -- -- Cluster-8309.16550 BP_3 1.00 0.98 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16553 BP_3 18.27 1.66 821 642917307 XP_008199245.1 237 1.8e-17 PREDICTED: disco-interacting protein 2 isoform X6 [Tribolium castaneum] 821000632 XM_012499594.1 35 1.26162e-06 PREDICTED: Nomascus leucogenys DIP2 disco-interacting protein 2 homolog C (Drosophila) (DIP2C), mRNA -- -- -- -- Q6NVJ5 178 5.0e-12 Disco-interacting protein 2 homolog B-A OS=Danio rerio GN=dip2ba PE=2 SV=1 PF01297//PF06464 Zinc-uptake complex component A periplasmic//DMAP1-binding Domain GO:0030001 metal ion transport GO:0008134//GO:0046872 transcription factor binding//metal ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3628 Predicted AMP-binding protein Cluster-8309.16556 BP_3 364.99 10.80 1920 642920562 XP_001816430.2 1281 3.6e-138 PREDICTED: uncharacterized protein LOC100141961 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 Q9Z0M5 452 2.0e-43 Lysosomal acid lipase/cholesteryl ester hydrolase OS=Mus musculus GN=Lipa PE=2 SV=2 PF04083//PF01764//PF01738 Partial alpha/beta-hydrolase lipase region//Lipase (class 3)//Dienelactone hydrolase family GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.1656 BP_3 23.49 2.53 740 642913095 XP_008201390.1 368 1.0e-32 PREDICTED: larval cuticle protein A2B-like [Tribolium castaneum]>gi|270001830|gb|EEZ98277.1| hypothetical protein TcasGA2_TC000720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80682 319 2.0e-28 Larval cuticle protein A2B OS=Tenebrio molitor PE=1 SV=1 PF04888//PF07460//PF00379 Secretion system effector C (SseC) like family//NUMOD3 motif (2 copies)//Insect cuticle protein GO:0009405 pathogenesis GO:0042302//GO:0003677 structural constituent of cuticle//DNA binding -- -- -- -- Cluster-8309.16562 BP_3 491.00 7.74 3349 91077078 XP_969608.1 3786 0.0e+00 PREDICTED: integrator complex subunit 7 [Tribolium castaneum] -- -- -- -- -- K13144 INTS7 integrator complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13144 Q9NVH2 1659 3.8e-183 Integrator complex subunit 7 OS=Homo sapiens GN=INTS7 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1988 Uncharacterized conserved protein Cluster-8309.16563 BP_3 70.90 3.31 1325 642938395 XP_971552.2 690 8.4e-70 PREDICTED: probable oligoribonuclease isoform X1 [Tribolium castaneum] -- -- -- -- -- K13288 orn, REX2, REXO2 oligoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K13288 Q9Y3B8 550 5.9e-55 Oligoribonuclease, mitochondrial OS=Homo sapiens GN=REXO2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3242 Oligoribonuclease (3'->5' exoribonuclease) Cluster-8309.16566 BP_3 314.87 11.38 1625 91094771 XP_967866.1 1686 3.3e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.2e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.16567 BP_3 5.00 0.79 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16570 BP_3 232.36 2.94 4105 642918349 XP_966635.3 1765 5.8e-194 PREDICTED: ecdysone-induced protein 78C [Tribolium castaneum] -- -- -- -- -- K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 P45447 834 2.1e-87 Ecdysone-induced protein 78C OS=Drosophila melanogaster GN=Eip78C PE=2 SV=4 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.16572 BP_3 11.00 0.95 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16579 BP_3 3003.53 108.74 1623 642919257 XP_008191796.1 1329 8.3e-144 PREDICTED: glucosamine-6-phosphate isomerase isoform X1 [Tribolium castaneum]>gi|642919259|ref|XP_008191797.1| PREDICTED: glucosamine-6-phosphate isomerase isoform X1 [Tribolium castaneum] 195473851 XM_002089170.1 181 1.75677e-87 Drosophila yakuba GE25482 (Dyak\GE25482), partial mRNA K02564 nagB, GNPDA glucosamine-6-phosphate deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K02564 Q16HW7 1213 9.6e-132 Glucosamine-6-phosphate isomerase OS=Aedes aegypti GN=Gnpda1 PE=3 SV=1 PF08022//PF01182 FAD-binding domain//Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase GO:0055114//GO:0005975 oxidation-reduction process//carbohydrate metabolic process GO:0016491 oxidoreductase activity -- -- KOG3148 Glucosamine-6-phosphate isomerase Cluster-8309.16580 BP_3 2.00 1.01 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16584 BP_3 113.00 10.69 801 478252911 ENN73295.1 495 2.1e-47 hypothetical protein YQE_10059, partial [Dendroctonus ponderosae] -- -- -- -- -- K14525 RPP25 ribonucleases P/MRP protein subunit RPP25 http://www.genome.jp/dbget-bin/www_bget?ko:K14525 Q8N5L8 283 3.3e-24 Ribonuclease P protein subunit p25-like protein OS=Homo sapiens GN=RPP25L PE=1 SV=1 PF01918 Alba -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16586 BP_3 9.36 1.76 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16588 BP_3 35.87 1.92 1191 332373854 AEE62068.1 1398 6.0e-152 unknown [Dendroctonus ponderosae] 642918806 XM_008193372.1 169 5.9922e-81 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase PP1-alpha-like (LOC103312533), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 P61287 1196 6.6e-130 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Bos taurus GN=PPP1CC PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.1659 BP_3 157.58 3.97 2205 189239672 XP_001813945.1 1739 3.2e-191 PREDICTED: serine proteinase stubble [Tribolium castaneum]>gi|270011208|gb|EFA07656.1| hypothetical protein TcasGA2_TC030609 [Tribolium castaneum] 642930385 XM_001813893.2 341 2.73411e-176 PREDICTED: Tribolium castaneum serine proteinase stubble (LOC662802), mRNA -- -- -- -- Q05319 650 2.5e-66 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00548//PF00089 3C cysteine protease (picornain 3C)//Trypsin GO:0006508 proteolysis GO:0004252//GO:0004197 serine-type endopeptidase activity//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.16592 BP_3 188.09 3.91 2611 642917912 XP_008191379.1 989 3.5e-104 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 531 1.9e-52 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101//PF04587 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain//ADP-specific Phosphofructokinase/Glucokinase conserved region GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0016758//GO:0016773 transferase activity, transferring hexosyl groups//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.16597 BP_3 27.24 0.44 3298 642927336 XP_974968.2 1026 2.3e-108 PREDICTED: protein prune homolog 2 [Tribolium castaneum] -- -- -- -- -- K18449 PRUNE2, BMCC1 prune homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18449 Q5BJR4 507 1.4e-49 Protein prune homolog 2 OS=Rattus norvegicus GN=Prune2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16599 BP_3 23.88 0.65 2067 642927336 XP_974968.2 945 3.5e-99 PREDICTED: protein prune homolog 2 [Tribolium castaneum] -- -- -- -- -- K18449 PRUNE2, BMCC1 prune homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18449 Q5BJR4 507 9.0e-50 Protein prune homolog 2 OS=Rattus norvegicus GN=Prune2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.166 BP_3 2.00 0.33 587 478253134 ENN73505.1 586 4.3e-58 hypothetical protein YQE_09756, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16601 BP_3 3.00 0.72 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16609 BP_3 406.00 32.12 901 91091246 XP_968473.1 511 3.3e-49 PREDICTED: RWD domain-containing protein 4 [Tribolium castaneum]>gi|270014113|gb|EFA10561.1| hypothetical protein TcasGA2_TC012817 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CPR1 330 1.3e-29 RWD domain-containing protein 4 OS=Mus musculus GN=Rwdd4 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.1661 BP_3 9.00 0.43 1297 642915450 XP_008190622.1 1451 4.7e-158 PREDICTED: E3 ubiquitin-protein ligase MYCBP2 [Tribolium castaneum] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 O75592 764 8.9e-80 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3 PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.16611 BP_3 2.00 0.96 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16612 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16613 BP_3 52.48 1.28 2270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16614 BP_3 36.52 0.88 2299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1662 BP_3 19.00 0.84 1387 617298650 XP_007549979.1 1311 8.6e-142 PREDICTED: malate dehydrogenase, mitochondrial [Poecilia formosa]>gi|617298657|ref|XP_007550217.1| PREDICTED: malate dehydrogenase, mitochondrial [Poecilia formosa] 262401156 FJ774760.1 541 0 Scylla paramamosain malate dehydrogenase mRNA, partial cds K00026 MDH2 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00026 Q5NVR2 1270 2.0e-138 Malate dehydrogenase, mitochondrial OS=Pongo abelii GN=MDH2 PE=2 SV=1 PF01073//PF01118//PF02866//PF02882//PF00056 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008210//GO:0009396//GO:0046487//GO:0008207//GO:0008209//GO:0055114//GO:0006694 estrogen metabolic process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0003824//GO:0003854//GO:0016491//GO:0004488//GO:0016616//GO:0051287//GO:0016620 catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-8309.16620 BP_3 5.00 0.33 1022 -- -- -- -- -- 299561003 GU183069.1 147 8.6947e-69 Scylla paramamosain microsatellite A548 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16622 BP_3 16.00 2.02 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03558 TBSV core protein P21/P22 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.16623 BP_3 53.97 1.49 2040 385843184 AFI80889.1 1884 4.6e-208 GluCl alpha subunit [Phyllotreta striolata] 768446852 XM_011567086.1 319 4.28748e-164 PREDICTED: Plutella xylostella glutamate-gated chloride channel-like (LOC105395149), partial mRNA K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 1685 2.2e-186 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.16624 BP_3 5.26 0.38 953 642911282 XP_008199355.1 834 1.2e-86 PREDICTED: glutamate-gated chloride channel isoform X5 [Tribolium castaneum] -- -- -- -- -- K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 670 5.2e-69 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.16625 BP_3 7.32 0.36 1275 385843184 AFI80889.1 274 1.4e-21 GluCl alpha subunit [Phyllotreta striolata] -- -- -- -- -- K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 168 1.1e-10 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16628 BP_3 7.00 0.57 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16632 BP_3 2.00 0.39 540 270001667 EEZ98114.1 270 1.7e-21 hypothetical protein TcasGA2_TC000532 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16634 BP_3 3.05 0.48 598 642937802 XP_008200306.1 291 7.0e-24 PREDICTED: cyclin-J [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRT8 140 9.3e-08 Cyclin-J-like protein OS=Mus musculus GN=Ccnjl PE=2 SV=1 PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.16635 BP_3 328.01 4.33 3939 189241548 XP_971070.2 613 2.1e-60 PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|642936933|ref|XP_008194513.1| PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|270001278|gb|EEZ97725.1| spatzle 5 [Tribolium castaneum] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q00420 454 2.4e-43 GA-binding protein subunit beta-1 OS=Mus musculus GN=Gabpb1 PE=1 SV=2 PF02984//PF13606//PF13869//PF00293//PF00023 Cyclin, C-terminal domain//Ankyrin repeat//Nucleotide hydrolase//NUDIX domain//Ankyrin repeat GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729//GO:0005515 hydrolase activity//mRNA binding//protein binding GO:0005634//GO:0005849 nucleus//mRNA cleavage factor complex -- -- Cluster-8309.16636 BP_3 148.62 1.82 4222 189241548 XP_971070.2 659 1.1e-65 PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|642936933|ref|XP_008194513.1| PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|270001278|gb|EEZ97725.1| spatzle 5 [Tribolium castaneum] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q00420 454 2.6e-43 GA-binding protein subunit beta-1 OS=Mus musculus GN=Gabpb1 PE=1 SV=2 PF02984//PF00023//PF13606//PF13869//PF00293 Cyclin, C-terminal domain//Ankyrin repeat//Ankyrin repeat//Nucleotide hydrolase//NUDIX domain GO:0006378 mRNA polyadenylation GO:0003729//GO:0005515//GO:0016787 mRNA binding//protein binding//hydrolase activity GO:0005634//GO:0005849 nucleus//mRNA cleavage factor complex -- -- Cluster-8309.16637 BP_3 29.27 0.33 4565 157115864 XP_001658319.1 608 9.3e-60 AAEL007364-PA [Aedes aegypti]>gi|108876729|gb|EAT40954.1| AAEL007364-PA [Aedes aegypti] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q502K3 254 4.3e-20 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Danio rerio GN=ankrd52 PE=2 SV=1 PF00023//PF00293//PF13869//PF13606//PF02984 Ankyrin repeat//NUDIX domain//Nucleotide hydrolase//Ankyrin repeat//Cyclin, C-terminal domain GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729//GO:0005515 hydrolase activity//mRNA binding//protein binding GO:0005634//GO:0005849 nucleus//mRNA cleavage factor complex -- -- Cluster-8309.16641 BP_3 26.05 1.05 1491 646724190 KDR24525.1 1484 8.1e-162 WD repeat-containing protein 40A, partial [Zootermopsis nevadensis] -- -- -- -- -- K11803 WDR40A WD repeat-containing protein 40A http://www.genome.jp/dbget-bin/www_bget?ko:K11803 Q5T6F0 673 3.6e-69 DDB1- and CUL4-associated factor 12 OS=Homo sapiens GN=DCAF12 PE=1 SV=1 PF03178//PF00400 CPSF A subunit region//WD domain, G-beta repeat -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.16644 BP_3 47.98 1.74 1623 546686050 ERL95450.1 207 1.0e-13 hypothetical protein D910_12712 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16646 BP_3 101.00 3.44 1708 731513203 XP_010599760.1 331 4.6e-28 PREDICTED: zinc finger protein 345-like isoform X2 [Loxodonta africana] 617460738 XM_007571845.1 34 9.64298e-06 PREDICTED: Poecilia formosa gastrula zinc finger protein XlCGF57.1-like (LOC103151666), mRNA K05706 SNAI2, SLUG snail 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05706 Q96MU6 326 7.2e-29 Zinc finger protein 778 OS=Homo sapiens GN=ZNF778 PE=1 SV=3 PF00096//PF13465//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.16648 BP_3 7.00 0.37 1212 91076406 XP_969383.1 1218 4.6e-131 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P80276 781 8.9e-82 Aldose reductase OS=Sus scrofa GN=AKR1B1 PE=1 SV=2 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain GO:0055114//GO:0046497//GO:0009435 oxidation-reduction process//nicotinate nucleotide metabolic process//NAD biosynthetic process GO:0004514//GO:0016491 nicotinate-nucleotide diphosphorylase (carboxylating) activity//oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.16650 BP_3 679.49 15.69 2379 646705367 KDR13121.1 1953 5.3e-216 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [Zootermopsis nevadensis] 617382302 XM_007546837.1 113 1.63989e-49 PREDICTED: Poecilia formosa SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (smarcd1), mRNA K11650 SMARCD SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D http://www.genome.jp/dbget-bin/www_bget?ko:K11650 Q9VYG2 1768 6.2e-196 Brahma-associated protein of 60 kDa OS=Drosophila melanogaster GN=Bap60 PE=1 SV=1 PF02201 SWIB/MDM2 domain -- -- GO:0005515 protein binding -- -- KOG2570 SWI/SNF transcription activation complex subunit Cluster-8309.16652 BP_3 69.63 0.86 4205 642934412 XP_008197650.1 541 5.1e-52 PREDICTED: transformer-2 protein homolog beta isoform X1 [Tribolium castaneum] 642934413 XM_008199429.1 299 1.16929e-152 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X2, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 3.7e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.16656 BP_3 4.00 0.57 628 546672698 ERL84489.1 784 5.0e-81 hypothetical protein D910_01919 [Dendroctonus ponderosae] -- -- -- -- -- K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q8NCM8 571 1.0e-57 Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens GN=DYNC2H1 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG3595 Dyneins, heavy chain Cluster-8309.16657 BP_3 6.00 0.39 1032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16659 BP_3 2.00 0.32 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16666 BP_3 134.14 1.59 4360 270009849 EFA06297.1 1167 1.4e-124 hypothetical protein TcasGA2_TC009164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AKG8 300 1.9e-25 Focadhesin OS=Mus musculus GN=Focad PE=2 SV=1 PF01105//PF08685 emp24/gp25L/p24 family/GOLD//GON domain GO:0006810 transport GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.16669 BP_3 1.00 0.68 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16671 BP_3 1.09 0.37 433 91088681 XP_974930.1 220 8.6e-16 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0005488 binding -- -- -- -- Cluster-8309.16673 BP_3 15.22 0.59 1526 270017158 EFA13604.1 652 2.5e-65 hypothetical protein TcasGA2_TC010302 [Tribolium castaneum] -- -- -- -- -- K01413 MMP12 matrix metalloproteinase-12 (macrophage elastase) http://www.genome.jp/dbget-bin/www_bget?ko:K01413 O13065 243 2.7e-19 Matrix metalloproteinase-18 OS=Xenopus laevis GN=mmp18 PE=2 SV=1 PF01400//PF10462//PF00413 Astacin (Peptidase family M12A)//Peptidase M66//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.16674 BP_3 2.00 0.38 546 795010007 XP_011864749.1 182 2.8e-11 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13443//PF13404//PF01047//PF09339 Cro/C1-type HTH DNA-binding domain//AsnC-type helix-turn-helix domain//MarR family//IclR helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.16676 BP_3 91.00 8.32 819 478253188 ENN73559.1 530 1.9e-51 hypothetical protein YQE_09809, partial [Dendroctonus ponderosae]>gi|546678937|gb|ERL89475.1| hypothetical protein D910_06841 [Dendroctonus ponderosae] -- -- -- -- -- K02990 RP-S6, MRPS6, rpsF small subunit ribosomal protein S6 http://www.genome.jp/dbget-bin/www_bget?ko:K02990 Q9VZD5 419 5.7e-40 Probable 28S ribosomal protein S6, mitochondrial OS=Drosophila melanogaster GN=mRpS6 PE=2 SV=1 PF01250//PF03484 Ribosomal protein S6//tRNA synthetase B5 domain GO:0042254//GO:0006412//GO:0006432 ribosome biogenesis//translation//phenylalanyl-tRNA aminoacylation GO:0000287//GO:0019843//GO:0003735//GO:0005524//GO:0003723 magnesium ion binding//rRNA binding//structural constituent of ribosome//ATP binding//RNA binding GO:0005840 ribosome KOG4708 Mitochondrial ribosomal protein MRP17 Cluster-8309.16680 BP_3 21.18 0.78 1595 675376006 KFM68908.1 181 1.1e-10 hypothetical protein X975_14817, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16681 BP_3 3.00 7.96 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16683 BP_3 14.96 4.20 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16684 BP_3 17.00 0.70 1464 662187915 XP_008487610.1 171 1.4e-09 PREDICTED: zinc finger X-chromosomal protein-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- P42283 137 5.1e-07 Longitudinals lacking protein, isoform G OS=Drosophila melanogaster GN=lola PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16685 BP_3 36.57 0.48 3932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16687 BP_3 83.79 1.08 4019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16688 BP_3 7.00 3.10 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16689 BP_3 16.00 2.11 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16690 BP_3 157.52 1.45 5513 270013163 EFA09611.1 936 1.0e-97 hypothetical protein TcasGA2_TC011732 [Tribolium castaneum] 194880702 XM_001974468.1 91 6.50124e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF00041//PF16656//PF08022 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//FAD-binding domain GO:0006771//GO:0055114//GO:0019497 riboflavin metabolic process//oxidation-reduction process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0016491//GO:0046872 acid phosphatase activity//protein binding//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.16693 BP_3 122.00 6.30 1225 646719319 KDR21474.1 619 1.3e-61 28S ribosomal protein S24, mitochondrial, partial [Zootermopsis nevadensis] -- -- -- -- -- K17403 MRPS24 small subunit ribosomal protein S24 http://www.genome.jp/dbget-bin/www_bget?ko:K17403 Q9VCC3 579 2.4e-58 28S ribosomal protein S24, mitochondrial OS=Drosophila melanogaster GN=mRpS24 PE=3 SV=1 PF14955 Mitochondrial ribosome subunit S24 -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.16695 BP_3 3.00 0.89 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16698 BP_3 22.63 0.39 3083 642915474 XP_008190634.1 2307 6.2e-257 PREDICTED: sorting nexin-14-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5W7 868 1.8e-91 Sorting nexin-14 OS=Homo sapiens GN=SNX14 PE=1 SV=3 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.16701 BP_3 198.00 5.58 2003 642939427 XP_008200386.1 575 2.7e-56 PREDICTED: uncharacterized protein LOC103314904 [Tribolium castaneum]>gi|270016505|gb|EFA12951.1| hypothetical protein TcasGA2_TC005071 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0BLU1 362 5.7e-33 E3 ubiquitin-protein ligase RNF168 OS=Xenopus tropicalis GN=rnf168 PE=2 SV=1 PF16685//PF13639//PF00097//PF14634//PF12678 zinc RING finger of MSL2//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-H2 zinc finger -- -- GO:0008270//GO:0005515//GO:0046872//GO:0061630 zinc ion binding//protein binding//metal ion binding//ubiquitin protein ligase activity -- -- -- -- Cluster-8309.16705 BP_3 19.48 0.32 3253 478252125 ENN72556.1 714 3.4e-72 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 201 4.3e-14 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.16706 BP_3 12.23 0.38 1861 546671832 ERL83974.1 390 7.2e-35 hypothetical protein D910_01284 [Dendroctonus ponderosae]>gi|546675381|gb|ERL86589.1| hypothetical protein D910_03996 [Dendroctonus ponderosae]>gi|546677899|gb|ERL88647.1| hypothetical protein D910_06031 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P41732 147 4.5e-08 Tetraspanin-7 OS=Homo sapiens GN=TSPAN7 PE=1 SV=2 PF04545//PF00335 Sigma-70, region 4//Tetraspanin family GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0016987//GO:0003677//GO:0003700 sigma factor activity//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.16708 BP_3 55.00 3.52 1044 642916815 XP_008199513.1 647 6.4e-65 PREDICTED: tRNA-splicing endonuclease subunit Sen34 [Tribolium castaneum] -- -- -- -- -- K15323 TSEN34 tRNA-splicing endonuclease subunit Sen34 http://www.genome.jp/dbget-bin/www_bget?ko:K15323 Q9BSV6 238 7.0e-19 tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens GN=TSEN34 PE=1 SV=1 PF01974 tRNA intron endonuclease, catalytic C-terminal domain GO:0051252//GO:0006388 regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0000213 tRNA-intron endonuclease activity GO:0000214 tRNA-intron endonuclease complex KOG4133 tRNA splicing endonuclease Cluster-8309.16709 BP_3 127.36 1.17 5530 642939444 XP_008200394.1 1205 6.7e-129 PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939446|ref|XP_008200396.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939448|ref|XP_008200397.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939450|ref|XP_008200398.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum] 642939445 XM_008202174.1 38 1.89182e-07 PREDICTED: Tribolium castaneum transcription factor E2F2-like (LOC656396), transcript variant X2, mRNA K06620 E2F3 transcription factor E2F3 http://www.genome.jp/dbget-bin/www_bget?ko:K06620 O00716 437 3.1e-41 Transcription factor E2F3 OS=Homo sapiens GN=E2F3 PE=1 SV=1 PF01991//PF02319 ATP synthase (E/31 kDa) subunit//E2F/DP family winged-helix DNA-binding domain GO:0015992//GO:0006355//GO:0015991//GO:0006119 proton transport//regulation of transcription, DNA-templated//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0046961//GO:0003700 proton-transporting ATPase activity, rotational mechanism//transcription factor activity, sequence-specific DNA binding GO:0033178//GO:0005667 proton-transporting two-sector ATPase complex, catalytic domain//transcription factor complex KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.16710 BP_3 12.72 1.12 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.16715 BP_3 14.00 0.56 1507 861584017 KMQ82327.1 190 9.1e-12 dna-mediated transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16727 BP_3 21.73 2.56 700 642937130 XP_008198705.1 159 1.7e-08 PREDICTED: short neuropeptide F-like [Tribolium castaneum]>gi|270001316|gb|EEZ97763.1| short neuropeptide F [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16729 BP_3 13.00 1.39 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16733 BP_3 227.56 6.85 1892 91089225 XP_968001.1 340 4.6e-29 PREDICTED: PRKR-interacting protein 1 homolog [Tribolium castaneum]>gi|270011471|gb|EFA07919.1| hypothetical protein TcasGA2_TC005495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNG8 221 1.2e-16 PRKR-interacting protein 1 homolog OS=Xenopus laevis GN=prkrip1 PE=2 SV=1 PF04999//PF02862 Cell division protein FtsL//DDHD domain GO:0051301//GO:0007049 cell division//cell cycle GO:0046872 metal ion binding GO:0016021 integral component of membrane KOG4055 Uncharacterized conserved protein Cluster-8309.16737 BP_3 343.74 15.73 1345 91089351 XP_972899.1 1099 3.2e-117 PREDICTED: developmentally-regulated GTP-binding protein 2 [Tribolium castaneum] 820863348 XR_001112833.1 325 1.29413e-167 PREDICTED: Apis florea developmentally-regulated GTP-binding protein 2 (LOC100865446), transcript variant X4, misc_RNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 964 5.9e-103 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF01926//PF08477//PF03193//PF00176//PF00005//PF02421 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//SNF2 family N-terminal domain//ABC transporter//Ferrous iron transport protein B GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0003924//GO:0015093//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding//ATPase activity GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.16738 BP_3 33.94 0.35 4978 270011439 EFA07887.1 457 3.3e-42 hypothetical protein TcasGA2_TC005461 [Tribolium castaneum] -- -- -- -- -- K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 Q9QXB9 375 4.4e-34 Developmentally-regulated GTP-binding protein 2 OS=Mus musculus GN=Drg2 PE=1 SV=1 PF05875//PF03006 Ceramidase//Haemolysin-III related GO:0006672//GO:0006807 ceramide metabolic process//nitrogen compound metabolic process GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.16739 BP_3 559.52 5.78 4955 769848297 XP_011635512.1 1496 1.1e-162 PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus]>gi|769848299|ref|XP_011635513.1| PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus] 572314861 XM_006623032.1 428 0 PREDICTED: Apis dorsata developmentally-regulated GTP-binding protein 2-like (LOC102680357), transcript variant X1, mRNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 1333 3.6e-145 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF02421//PF03006//PF03193//PF00176//PF01926 Ferrous iron transport protein B//Haemolysin-III related//Protein of unknown function, DUF258//SNF2 family N-terminal domain//50S ribosome-binding GTPase GO:0015684 ferrous iron transport GO:0003924//GO:0015093//GO:0005524//GO:0005525 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.16740 BP_3 21.87 0.42 2779 642924318 XP_008194246.1 711 6.5e-72 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 264 1.8e-21 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 -- -- GO:0006820//GO:0006821 anion transport//chloride transport GO:0005254 chloride channel activity GO:0034707 chloride channel complex -- -- Cluster-8309.16742 BP_3 23.65 0.33 3784 91083957 XP_975021.1 902 6.3e-94 PREDICTED: caldesmon [Tribolium castaneum]>gi|270006722|gb|EFA03170.1| hypothetical protein TcasGA2_TC013090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09002 147 9.1e-08 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF00318//PF13741//PF14372//PF02075//PF00836 Ribosomal protein S2//Mitochondrial ribosomal protein S25//Domain of unknown function (DUF4413)//Crossover junction endodeoxyribonuclease RuvC//Stathmin family GO:0006281//GO:0006412//GO:0006308//GO:0042254//GO:0006310//GO:0031110 DNA repair//translation//DNA catabolic process//ribosome biogenesis//DNA recombination//regulation of microtubule polymerization or depolymerization GO:0004520//GO:0003677//GO:0003735 endodeoxyribonuclease activity//DNA binding//structural constituent of ribosome GO:0005763//GO:0005840//GO:0005622 mitochondrial small ribosomal subunit//ribosome//intracellular -- -- Cluster-8309.16746 BP_3 2.35 0.46 539 642917566 XP_008191259.1 271 1.3e-21 PREDICTED: transmembrane protein 258-like [Tribolium castaneum]>gi|642939410|ref|XP_008193314.1| PREDICTED: transmembrane protein 258 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q76LT9 249 1.9e-20 Transmembrane protein 258 OS=Gallus gallus GN=TMEM258 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4452 Predicted membrane protein Cluster-8309.16751 BP_3 4.00 5.49 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07034 Origin recognition complex (ORC) subunit 3 N-terminus GO:0006260 DNA replication GO:0003677 DNA binding GO:0005664 nuclear origin of replication recognition complex -- -- Cluster-8309.16752 BP_3 9.62 0.89 815 189239328 XP_973240.2 515 1.0e-49 PREDICTED: ribosome-releasing factor 2, mitochondrial [Tribolium castaneum] 242013425 XM_002427363.1 41 5.78394e-10 Pediculus humanus corporis elongation factor G 2, putative, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 Q7Q3I6 423 1.9e-40 Ribosome-releasing factor 2, mitochondrial OS=Anopheles gambiae GN=AGAP007894 PE=3 SV=4 PF04548//PF01926 AIG1 family//50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- KOG0465 Mitochondrial elongation factor Cluster-8309.16756 BP_3 202.35 16.72 875 91076134 XP_970027.1 632 2.9e-63 PREDICTED: uncharacterized protein LOC658556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16757 BP_3 17.10 0.58 1709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14552 Tautomerase enzyme GO:0006725 cellular aromatic compound metabolic process GO:0016853 isomerase activity -- -- -- -- Cluster-8309.16758 BP_3 5.00 0.31 1079 861625527 KMQ88569.1 878 1.1e-91 retrovirus-like pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q9UR07 205 4.9e-15 Transposon Tf2-11 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-11 PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.16759 BP_3 41.58 1.31 1827 270015831 EFA12279.1 637 1.6e-63 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16765 BP_3 271.00 20.46 930 91081497 XP_974526.1 964 1.0e-101 PREDICTED: trafficking protein particle complex subunit 4 [Tribolium castaneum]>gi|270005142|gb|EFA01590.1| hypothetical protein TcasGA2_TC007153 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2TBL9 709 1.5e-73 Trafficking protein particle complex subunit 4 OS=Bos taurus GN=TRAPPC4 PE=2 SV=1 PF04099//PF04628//PF00595 Sybindin-like family//Sedlin, N-terminal conserved region//PDZ domain (Also known as DHR or GLGF) GO:0006888 ER to Golgi vesicle-mediated transport GO:0005515 protein binding GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3369 Transport protein particle (TRAPP) complex subunit Cluster-8309.16768 BP_3 285.89 13.59 1306 270008323 EFA04771.1 688 1.4e-69 hypothetical protein TcasGA2_TC030678 [Tribolium castaneum] -- -- -- -- -- K03012 RPB4, POLR2D DNA-directed RNA polymerase II subunit RPB4 http://www.genome.jp/dbget-bin/www_bget?ko:K03012 Q9VEA5 561 3.1e-56 DNA-directed RNA polymerase II 16 kDa polypeptide OS=Drosophila melanogaster GN=Rpb4 PE=2 SV=5 PF03850//PF04958//PF03874 Transcription factor Tfb4//Arginine N-succinyltransferase beta subunit//RNA polymerase Rpb4 GO:0006527//GO:0006144//GO:0042967//GO:0006560//GO:0006351//GO:0006289//GO:0006355//GO:0006206 arginine catabolic process//purine nucleobase metabolic process//acyl-carrier-protein biosynthetic process//proline metabolic process//transcription, DNA-templated//nucleotide-excision repair//regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0008791 DNA-directed RNA polymerase activity//arginine N-succinyltransferase activity GO:0005730//GO:0000439 nucleolus//core TFIIH complex KOG2351 RNA polymerase II, fourth largest subunit Cluster-8309.16772 BP_3 16.00 4.18 476 831278612 XP_012670242.1 560 3.6e-55 PREDICTED: 40S ribosomal protein S17 [Clupea harengus] 545175896 XM_001502832.3 184 1.05402e-89 PREDICTED: Equus caballus 40S ribosomal protein S17-like (LOC100065786), mRNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 Q6QAP7 556 4.3e-56 40S ribosomal protein S17 OS=Sus scrofa GN=RPS17 PE=1 SV=3 PF00833 Ribosomal S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0187 40S ribosomal protein S17 Cluster-8309.16778 BP_3 338.92 5.04 3534 91087237 XP_975509.1 1259 2.4e-135 PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|642929695|ref|XP_008195939.1| PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|270010578|gb|EFA07026.1| hypothetical protein TcasGA2_TC009997 [Tribolium castaneum] 827564585 CP011663.1 41 2.58893e-09 Clostridium sporogenes strain DSM 795, complete genome K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 1035 9.1e-111 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF00490//PF16834 Delta-aminolevulinic acid dehydratase//Shu complex component Csm2, DNA-binding GO:0015994//GO:0033014//GO:0000725 chlorophyll metabolic process//tetrapyrrole biosynthetic process//recombinational repair GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding GO:0005634//GO:0097196 nucleus//Shu complex KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.16783 BP_3 10.39 0.36 1686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16788 BP_3 140.00 12.07 851 478251069 ENN71548.1 639 4.4e-64 hypothetical protein YQE_11776, partial [Dendroctonus ponderosae]>gi|546677072|gb|ERL87981.1| hypothetical protein D910_05369 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VY86 518 2.0e-51 TM2 domain-containing protein CG11103 OS=Drosophila melanogaster GN=CG11103 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4272 Predicted GTP-binding protein Cluster-8309.16790 BP_3 614.43 13.74 2447 270010175 EFA06623.1 2604 1.8e-291 hypothetical protein TcasGA2_TC009541 [Tribolium castaneum] 687022647 LM525561.1 43 1.38045e-10 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_scaffold0000006 K10481 BTBD9 BTB/POZ domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10481 A4IFG2 1654 1.1e-182 BTB/POZ domain-containing protein 9 OS=Bos taurus GN=BTBD9 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.16795 BP_3 132.00 1.49 4562 820239016 BAR72977.1 1879 3.9e-207 cytochrome P450 15A1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q6R7M4 1354 1.2e-147 Methyl farnesoate epoxidase OS=Diploptera punctata GN=CYP15A1 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.16796 BP_3 59.64 1.40 2346 531443692 AGT57832.1 1428 4.0e-155 cytochrome P450 305a1, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9VW43 1035 6.1e-111 Probable cytochrome P450 305a1 OS=Drosophila melanogaster GN=Cyp305a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.1680 BP_3 25.40 0.92 1616 546685820 ERL95263.1 1240 1.7e-133 hypothetical protein D910_12529 [Dendroctonus ponderosae] 40849966 AY450270.1 234 6.0292e-117 Ctenopharyngodon idella hypoxia-inducible factor-4alpha (hif-4alpha) mRNA, complete cds -- -- -- -- -- -- -- -- PF04843 Herpesvirus tegument protein, N-terminal conserved region GO:0006508 proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-8309.16802 BP_3 6.00 4.44 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16806 BP_3 13.00 0.91 983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16808 BP_3 3149.46 80.82 2170 546672570 ERL84380.1 1767 1.8e-194 hypothetical protein D910_01810 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q99046 398 4.1e-37 Laccase-2 OS=Trametes villosa GN=LCC2 PE=3 SV=1 PF07731//PF00394//PF07732 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- -- -- Cluster-8309.16814 BP_3 28.14 0.63 2437 189235061 XP_001814285.1 1066 3.9e-113 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18715 217 4.5e-16 Gastrula zinc finger protein XlCGF26.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF00096//PF13465//PF16622//PF13912//PF02892//PF04810 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.16818 BP_3 1.00 2.12 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16819 BP_3 120.81 0.74 8144 642913946 XP_008201225.1 10151 0.0e+00 PREDICTED: leucine-rich repeat serine/threonine-protein kinase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TZM3 2900 0.0e+00 Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6 PF00025//PF13855//PF13606//PF07714//PF00069//PF08477//PF00071//PF07645 ADP-ribosylation factor family//Leucine rich repeat//Ankyrin repeat//Protein tyrosine kinase//Protein kinase domain//Ras of Complex, Roc, domain of DAPkinase//Ras family//Calcium-binding EGF domain GO:0007264//GO:0006468 small GTPase mediated signal transduction//protein phosphorylation GO:0005525//GO:0005524//GO:0005509//GO:0005515//GO:0004672 GTP binding//ATP binding//calcium ion binding//protein binding//protein kinase activity -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.16822 BP_3 49.00 0.99 2684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16823 BP_3 54.91 1.98 1631 478262315 ENN81032.1 964 1.7e-101 hypothetical protein YQE_02551, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P10076 434 2.1e-41 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF07776//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.16825 BP_3 34.21 0.71 2627 270002842 EEZ99289.1 1890 1.2e-208 groucho-like protein [Tribolium castaneum] 831531239 XM_012865661.1 255 2.09473e-128 PREDICTED: Fundulus heteroclitus transducin-like enhancer protein 4 (LOC105928411), transcript variant X2, mRNA -- -- -- -- Q04726 1703 2.4e-188 Transducin-like enhancer protein 3 OS=Homo sapiens GN=TLE3 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.16828 BP_3 13.00 5.52 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16829 BP_3 896.92 23.87 2103 642936055 XP_008198283.1 1363 1.2e-147 PREDICTED: fringe glycosyltransferase [Tribolium castaneum]>gi|270013211|gb|EFA09659.1| hypothetical protein TcasGA2_TC011785 [Tribolium castaneum] 462318872 APGK01044259.1 47 7.07303e-13 Dendroctonus ponderosae Seq01044269, whole genome shotgun sequence K05948 FNG fringe http://www.genome.jp/dbget-bin/www_bget?ko:K05948 Q24342 1053 4.4e-113 Fringe glycosyltransferase OS=Drosophila melanogaster GN=fng PE=1 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.16832 BP_3 1.00 0.82 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006814//GO:0006090//GO:0071436//GO:0006560//GO:0006525 sodium ion transport//pyruvate metabolic process//sodium ion export//proline metabolic process//arginine metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.16836 BP_3 52.00 1.39 2092 268370072 NP_001161228.1 1375 4.9e-149 phosphatidylinositol glycan, class B [Tribolium castaneum] -- -- -- -- -- K05286 PIGB phosphatidylinositol glycan, class B http://www.genome.jp/dbget-bin/www_bget?ko:K05286 Q9VZM5 1081 2.5e-116 GPI mannosyltransferase 3 OS=Drosophila melanogaster GN=CG12006 PE=2 SV=2 PF03901 Alg9-like mannosyltransferase family -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis Cluster-8309.16837 BP_3 36.00 3.14 844 828227358 XP_012563911.1 250 5.6e-19 PREDICTED: uncharacterized protein LOC105848376, partial [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15178 Mitochondrial import receptor subunit TOM5 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.16840 BP_3 42.10 0.93 2479 642927181 XP_008195169.1 2351 3.9e-262 PREDICTED: synaptic vesicle glycoprotein 2B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q7L1I2 482 8.5e-47 Synaptic vesicle glycoprotein 2B OS=Homo sapiens GN=SV2B PE=1 SV=1 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.16843 BP_3 16.00 0.41 2167 861601583 KMQ83835.1 535 1.3e-51 hypothetical protein RF55_19003 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16844 BP_3 157.84 3.54 2441 189239328 XP_973240.2 2486 8.6e-278 PREDICTED: ribosome-releasing factor 2, mitochondrial [Tribolium castaneum] 242013425 XM_002427363.1 101 7.88708e-43 Pediculus humanus corporis elongation factor G 2, putative, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 Q9VCX4 1778 4.4e-197 Ribosome-releasing factor 2, mitochondrial OS=Drosophila melanogaster GN=EF-G2 PE=2 SV=3 PF03144//PF01926//PF04548 Elongation factor Tu domain 2//50S ribosome-binding GTPase//AIG1 family -- -- GO:0005525 GTP binding -- -- KOG0465 Mitochondrial elongation factor Cluster-8309.16845 BP_3 38.04 0.71 2881 270001480 EEZ97927.1 553 1.4e-53 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H5L6 198 8.5e-14 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16847 BP_3 733.03 12.01 3234 91076346 XP_966525.1 1658 1.2e-181 PREDICTED: leucine zipper putative tumor suppressor 2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4W1 429 1.6e-40 Leucine zipper putative tumor suppressor 2 homolog OS=Xenopus laevis GN=lzts2 PE=2 SV=1 PF10288//PF01008//PF00769 Cytoplasmic tRNA 2-thiolation protein 2//Initiation factor 2 subunit family//Ezrin/radixin/moesin family GO:0034227//GO:0044237//GO:0002098 tRNA thio-modification//cellular metabolic process//tRNA wobble uridine modification GO:0008092//GO:0000049 cytoskeletal protein binding//tRNA binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm -- -- Cluster-8309.1685 BP_3 5.00 0.40 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16856 BP_3 226.00 18.36 885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16858 BP_3 12.19 0.52 1416 642912496 XP_008200890.1 409 3.5e-37 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.16865 BP_3 31.48 1.02 1786 91079744 XP_970506.1 1271 4.8e-137 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 253560541 GQ232416.1 50 1.28721e-14 Culex pipiens pipiens putative acyl-CoA dehydrogenase (ACD-1) mRNA, partial cds K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 1240 7.8e-135 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF02770//PF08047//PF00441 Acyl-CoA dehydrogenase, middle domain//Histidine operon leader peptide//Acyl-CoA dehydrogenase, C-terminal domain GO:0000105//GO:0055114//GO:0006118 histidine biosynthetic process//oxidation-reduction process//obsolete electron transport GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.16866 BP_3 37.60 0.34 5623 861641601 KMQ93606.1 611 5.2e-60 nuclear valosin-containing [Lasius niger] -- -- -- -- -- -- -- -- -- Q03277 322 6.9e-28 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Fragment) OS=Bradysia coprophila PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16867 BP_3 47.80 0.45 5431 861641601 KMQ93606.1 609 8.5e-60 nuclear valosin-containing [Lasius niger] -- -- -- -- -- -- -- -- -- Q03277 322 6.7e-28 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Fragment) OS=Bradysia coprophila PE=3 SV=1 PF02932//PF02064//PF01080//PF07851//PF03092//PF01956//PF11427//PF03938 Neurotransmitter-gated ion-channel transmembrane region//MAS20 protein import receptor//Presenilin//TMPIT-like protein//BT1 family//Integral membrane protein DUF106//Tc3 transposase//Outer membrane protein (OmpH-like) GO:0006811//GO:0006810//GO:0006886//GO:0006605 ion transport//transport//intracellular protein transport//protein targeting GO:0051082//GO:0003677//GO:0004190 unfolded protein binding//DNA binding//aspartic-type endopeptidase activity GO:0005742//GO:0016020//GO:0016021 mitochondrial outer membrane translocase complex//membrane//integral component of membrane -- -- Cluster-8309.16873 BP_3 136.46 1.87 3808 91085531 XP_972280.1 1517 3.1e-165 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q8VC97 1228 4.1e-133 Beta-ureidopropionase OS=Mus musculus GN=Upb1 PE=2 SV=1 PF00473//PF00795 Corticotropin-releasing factor family//Carbon-nitrogen hydrolase GO:0007165//GO:0006807 signal transduction//nitrogen compound metabolic process GO:0005179//GO:0016810 hormone activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0005576 extracellular region KOG2648 Diphthamide biosynthesis protein Cluster-8309.16876 BP_3 14.56 0.73 1259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16879 BP_3 14.41 0.77 1194 91080689 XP_975235.1 441 5.7e-41 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [Tribolium castaneum]>gi|270006426|gb|EFA02874.1| hypothetical protein TcasGA2_TC007967 [Tribolium castaneum] 642919565 XM_970142.2 45 5.12781e-12 PREDICTED: Tribolium castaneum NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (LOC664127), mRNA K03953 NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03953 -- -- -- -- -- -- GO:0044237 cellular metabolic process GO:0050662//GO:0003824//GO:0000166 coenzyme binding//catalytic activity//nucleotide binding -- -- -- -- Cluster-8309.1688 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16880 BP_3 1.00 0.88 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16896 BP_3 1.00 1.37 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16899 BP_3 2049.34 73.26 1640 478249977 ENN70484.1 828 1.0e-85 hypothetical protein YQE_12987, partial [Dendroctonus ponderosae]>gi|546679646|gb|ERL90077.1| hypothetical protein D910_07432 [Dendroctonus ponderosae] -- -- -- -- -- K06201 cutC copper homeostasis protein http://www.genome.jp/dbget-bin/www_bget?ko:K06201 Q9NTM9 492 3.9e-48 Copper homeostasis protein cutC homolog OS=Homo sapiens GN=CUTC PE=1 SV=1 PF00121//PF02581//PF03932//PF01081 Triosephosphate isomerase//Thiamine monophosphate synthase/TENI//CutC family//KDPG and KHG aldolase GO:0009228//GO:0006020//GO:0006096//GO:0008152//GO:0055070//GO:0006000//GO:0046486//GO:0006013//GO:0006094//GO:0015976 thiamine biosynthetic process//inositol metabolic process//glycolytic process//metabolic process//copper ion homeostasis//fructose metabolic process//glycerolipid metabolic process//mannose metabolic process//gluconeogenesis//carbon utilization GO:0004789//GO:0005507//GO:0004807//GO:0016829 thiamine-phosphate diphosphorylase activity//copper ion binding//triose-phosphate isomerase activity//lyase activity -- -- KOG4013 Predicted Cu2+ homeostasis protein CutC Cluster-8309.16900 BP_3 174.64 2.07 4367 642911114 XP_008200584.1 3555 0.0e+00 PREDICTED: tyrosine-protein phosphatase 99A [Tribolium castaneum] 195445683 XM_002070402.1 103 1.09718e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2408 7.0e-270 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00782//PF00041//PF00102 Dual specificity phosphatase, catalytic domain//Fibronectin type III domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding -- -- -- -- Cluster-8309.16903 BP_3 6.60 1.57 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16906 BP_3 10.69 1.06 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16907 BP_3 43.49 1.04 2303 91095137 XP_972151.1 753 7.2e-77 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 1.93961e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 637 8.4e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.16908 BP_3 14.35 0.34 2330 642915450 XP_008190622.1 2541 3.4e-284 PREDICTED: E3 ubiquitin-protein ligase MYCBP2 [Tribolium castaneum] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 Q7TPH6 1616 2.6e-178 E3 ubiquitin-protein ligase MYCBP2 OS=Mus musculus GN=Mycbp2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.16919 BP_3 19.18 0.91 1312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04189 Gcd10p family GO:0030488 tRNA methylation -- -- GO:0031515 tRNA (m1A) methyltransferase complex -- -- Cluster-8309.1692 BP_3 11.00 0.37 1706 645025511 XP_008218023.1 225 9.0e-16 PREDICTED: uncharacterized protein LOC103318169 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- P04323 143 1.2e-07 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16921 BP_3 15.25 0.94 1073 675380592 KFM73494.1 196 1.3e-12 hypothetical protein X975_07201, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16924 BP_3 44.59 1.50 1720 642937110 XP_008198695.1 493 7.6e-47 PREDICTED: major facilitator superfamily domain-containing protein 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBP5 144 9.2e-08 Major facilitator superfamily domain-containing protein 9 OS=Homo sapiens GN=MFSD9 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.16925 BP_3 7.00 1.77 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16926 BP_3 254.16 5.35 2582 189239136 XP_971870.2 1153 3.4e-123 PREDICTED: abhydrolase domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- K13698 ABHD4 abhydrolase domain-containing protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13698 Q8VD66 771 2.7e-80 Abhydrolase domain-containing protein 4 OS=Mus musculus GN=Abhd4 PE=2 SV=1 PF00975//PF03403//PF07859//PF01764 Thioesterase domain//Platelet-activating factor acetylhydrolase, isoform II//alpha/beta hydrolase fold//Lipase (class 3) GO:0016042//GO:0009058//GO:0046486//GO:0008152//GO:0006629 lipid catabolic process//biosynthetic process//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0003847//GO:0016787//GO:0016788 1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.16927 BP_3 18.84 0.38 2709 189239136 XP_971870.2 821 1.1e-84 PREDICTED: abhydrolase domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- K13698 ABHD4 abhydrolase domain-containing protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13698 Q5EA59 623 4.2e-63 Abhydrolase domain-containing protein 4 OS=Bos taurus GN=ABHD4 PE=2 SV=1 PF00975//PF07859//PF03403//PF07819//PF01764 Thioesterase domain//alpha/beta hydrolase fold//Platelet-activating factor acetylhydrolase, isoform II//PGAP1-like protein//Lipase (class 3) GO:0006505//GO:0008152//GO:0006886//GO:0006629//GO:0016042//GO:0046486//GO:0009058 GPI anchor metabolic process//metabolic process//intracellular protein transport//lipid metabolic process//lipid catabolic process//glycerolipid metabolic process//biosynthetic process GO:0016787//GO:0003847//GO:0016788 hydrolase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.16928 BP_3 57.73 1.04 2963 189236145 XP_974763.2 1411 4.7e-153 PREDICTED: diphthine--ammonia ligase [Tribolium castaneum]>gi|270005602|gb|EFA02050.1| hypothetical protein TcasGA2_TC007678 [Tribolium castaneum] -- -- -- -- -- K06927 DPH6 diphthine-ammonia ligase http://www.genome.jp/dbget-bin/www_bget?ko:K06927 Q2HJF5 794 6.7e-83 Diphthine--ammonia ligase OS=Bos taurus GN=DPH6 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2316 Predicted ATPase (PP-loop superfamily) Cluster-8309.1693 BP_3 77.00 2.76 1635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16936 BP_3 96.15 3.66 1557 642915218 XP_008190526.1 1696 2.2e-186 PREDICTED: UDP-glucose 6-dehydrogenase isoform X1 [Tribolium castaneum] 332376888 BT128627.1 168 2.83753e-80 Dendroctonus ponderosae clone DPO012_D10 unknown mRNA K00012 UGDH, ugd UDPglucose 6-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00012 O02373 1573 1.7e-173 UDP-glucose 6-dehydrogenase OS=Drosophila melanogaster GN=sgl PE=1 SV=1 PF00984//PF03446//PF03721//PF03720 UDP-glucose/GDP-mannose dehydrogenase family, central domain//NAD binding domain of 6-phosphogluconate dehydrogenase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain GO:0006098//GO:0019521//GO:0055114 pentose-phosphate shunt//D-gluconate metabolic process//oxidation-reduction process GO:0004616//GO:0016616//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG2666 UDP-glucose/GDP-mannose dehydrogenase Cluster-8309.16937 BP_3 53.00 1.62 1872 642927799 XP_008195409.1 168 4.0e-09 PREDICTED: uncharacterized protein LOC103313581 [Tribolium castaneum]>gi|270009878|gb|EFA06326.1| hypothetical protein TcasGA2_TC009197 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16939 BP_3 7.62 1.36 562 189233768 XP_001814337.1 267 4.0e-21 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 221 3.5e-17 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086 Jagunal, ER re-organisation during oogenesis GO:0007029 endoplasmic reticulum organization -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.16943 BP_3 6.97 1.05 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16947 BP_3 4.00 0.65 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1695 BP_3 6.18 0.82 653 270007495 EFA03943.1 376 1.1e-33 hypothetical protein TcasGA2_TC014087 [Tribolium castaneum] -- -- -- -- -- K08834 MYO3, DFNB30 myosin III http://www.genome.jp/dbget-bin/www_bget?ko:K08834 P10676 263 5.5e-22 Neither inactivation nor afterpotential protein C OS=Drosophila melanogaster GN=ninaC PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.16950 BP_3 1.00 7.02 253 270004866 EFA01314.1 259 1.5e-20 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K06252 TN tenascin http://www.genome.jp/dbget-bin/www_bget?ko:K06252 Q5XK91 221 1.6e-17 Fibrinogen C domain-containing protein 1-B OS=Xenopus laevis GN=fibcd1-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16951 BP_3 76.32 3.30 1406 676446104 XP_009050970.1 147 8.2e-07 hypothetical protein LOTGIDRAFT_159061 [Lottia gigantea]>gi|556109613|gb|ESO98265.1| hypothetical protein LOTGIDRAFT_159061 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14659 Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.16954 BP_3 39.00 3.57 818 307165921 EFN60256.1 345 5.2e-30 hypothetical protein EAG_00437, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16956 BP_3 117.28 1.81 3410 478252068 ENN72499.1 334 4.1e-28 hypothetical protein YQE_10840, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5UPA0 134 2.6e-06 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16962 BP_3 15.01 0.57 1551 270003816 EFA00264.1 206 1.3e-13 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF16622//PF13465//PF02701//PF00096 BED zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Dof domain, zinc finger//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.16965 BP_3 1.00 0.62 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16966 BP_3 4.08 0.44 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1697 BP_3 3.00 1.37 396 742169166 XP_010885180.1 411 5.6e-38 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [Esox lucius] -- -- -- -- -- K03949 NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03949 Q4R5J1 372 7.7e-35 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Macaca fascicularis GN=NDUFA5 PE=3 SV=3 PF00804//PF04716 Syntaxin//ETC complex I subunit conserved region GO:0022904 respiratory electron transport chain GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0005743//GO:0016020 mitochondrial inner membrane//membrane KOG3365 NADH:ubiquinone oxidoreductase, NDUFA5/B13 subunit Cluster-8309.16972 BP_3 13.42 0.97 960 642924540 XP_008194336.1 243 4.1e-18 PREDICTED: larval cuticle protein LCP-30 [Tribolium castaneum]>gi|270006766|gb|EFA03214.1| hypothetical protein TcasGA2_TC013134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16973 BP_3 10.97 0.55 1251 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16974 BP_3 9.58 0.70 947 817206159 XP_012279008.1 416 3.6e-38 PREDICTED: nuclear cap-binding protein subunit 2 [Orussus abietinus] 572310349 XM_006620871.1 127 1.05416e-57 PREDICTED: Apis dorsata nuclear cap-binding protein subunit 2-like (LOC102673777), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 392 8.9e-37 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.16975 BP_3 49.64 1.49 1893 436466 CAA82360.1 633 4.9e-63 putative transposase [Drosophila hydei]>gi|743805|prf||2013359A transposase -- -- -- -- -- -- -- -- -- Q04202 284 5.9e-24 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 PF03184//PF04545//PF06056//PF13463//PF00292//PF00440//PF08281//PF08541//PF04218//PF01498 DDE superfamily endonuclease//Sigma-70, region 4//Putative ATPase subunit of terminase (gpP-like)//Winged helix DNA-binding domain//'Paired box' domain//Bacterial regulatory proteins, tetR family//Sigma-70, region 4//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//CENP-B N-terminal DNA-binding domain//Transposase GO:0006313//GO:0006355//GO:0008610//GO:0019069//GO:0006352//GO:0015074 transposition, DNA-mediated//regulation of transcription, DNA-templated//lipid biosynthetic process//viral capsid assembly//DNA-templated transcription, initiation//DNA integration GO:0005524//GO:0003677//GO:0016987//GO:0003676//GO:0003700//GO:0016747 ATP binding//DNA binding//sigma factor activity//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005667 transcription factor complex -- -- Cluster-8309.16976 BP_3 5.00 0.92 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16977 BP_3 17.00 0.85 1254 270008349 EFA04797.1 148 5.6e-07 hypothetical protein TcasGA2_TC014846 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16980 BP_3 16.00 0.72 1368 815796965 XP_012219160.1 187 1.8e-11 PREDICTED: uncharacterized protein LOC105670293 isoform X5 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16981 BP_3 212.33 2.34 4674 642933180 XP_008197291.1 1842 7.8e-203 PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X3 [Tribolium castaneum] 430763429 JQ753065.1 49 1.2259e-13 Aedes aegypti strain Liverpool Kir1 channel protein mRNA, complete cds K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 P48543 896 1.6e-94 G protein-activated inward rectifier potassium channel 3 OS=Mus musculus GN=Kcnj9 PE=2 SV=2 PF00520//PF01007//PF10716 Ion transport protein//Inward rectifier potassium channel//NADH dehydrogenase transmembrane subunit GO:0006118//GO:0006811//GO:0055114//GO:0055085//GO:0006813 obsolete electron transport//ion transport//oxidation-reduction process//transmembrane transport//potassium ion transport GO:0005216//GO:0016655//GO:0005242 ion channel activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//inward rectifier potassium channel activity GO:0016020//GO:0008076//GO:0016021 membrane//voltage-gated potassium channel complex//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.16983 BP_3 104.62 17.07 587 471180443 AGI05172.1 382 1.9e-34 chemosensory protein 2 [Dendroctonus ponderosae]>gi|478257979|gb|ENN78117.1| hypothetical protein YQE_05271, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 270 7.7e-23 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16984 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16985 BP_3 18.00 0.80 1379 817086814 XP_012266154.1 187 1.9e-11 PREDICTED: protein transport protein Sec61 subunit beta [Athalia rosae] -- -- -- -- -- K09481 SEC61B, SBH2 protein transport protein SEC61 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K09481 P60467 144 7.4e-08 Protein transport protein Sec61 subunit beta OS=Canis familiaris GN=SEC61B PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16989 BP_3 65.41 3.59 1169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1699 BP_3 4.67 0.99 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16999 BP_3 85.90 1.09 4099 642926092 XP_008194763.1 1772 8.9e-195 PREDICTED: MAP/microtubule affinity-regulating kinase 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REX1 141 4.9e-07 Serine/threonine-protein kinase SIK2 OS=Pongo abelii GN=SIK2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.170 BP_3 8.99 0.50 1155 91086171 XP_970531.1 565 2.3e-55 PREDICTED: uncharacterized protein LOC659106 [Tribolium castaneum]>gi|270009881|gb|EFA06329.1| hypothetical protein TcasGA2_TC009200 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1700 BP_3 31.00 4.27 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17001 BP_3 167.57 0.70 11794 189238915 XP_969200.2 4812 0.0e+00 PREDICTED: DNA polymerase epsilon catalytic subunit A [Tribolium castaneum] -- -- -- -- -- K02324 POLE1 DNA polymerase epsilon subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02324 Q07864 4076 0.0e+00 DNA polymerase epsilon catalytic subunit A OS=Homo sapiens GN=POLE PE=1 SV=5 PF02177//PF00711//PF00136//PF00322//PF03104//PF13482//PF08115 Amyloid A4 N-terminal heparin-binding//Beta defensin//DNA polymerase family B//Endothelin family//DNA polymerase family B, exonuclease domain//RNase_H superfamily//SFI toxin family GO:0009405//GO:0006952//GO:0019229 pathogenesis//defense response//regulation of vasoconstriction GO:0000166//GO:0008408//GO:0003676//GO:0008201//GO:0003677 nucleotide binding//3'-5' exonuclease activity//nucleic acid binding//heparin binding//DNA binding GO:0005576 extracellular region KOG1798 DNA polymerase epsilon, catalytic subunit A Cluster-8309.17004 BP_3 33.57 0.67 2700 828235266 XP_012566344.1 1188 3.1e-127 PREDICTED: tigger transposable element-derived protein 1-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF04218//PF05225//PF02232 DDE superfamily endonuclease//CENP-B N-terminal DNA-binding domain//helix-turn-helix, Psq domain//Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.17007 BP_3 6.00 2.76 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17009 BP_3 22.64 0.56 2243 270015520 EFA11968.1 551 1.9e-53 hypothetical protein TcasGA2_TC004049 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q87040 199 5.0e-14 Pro-Pol polyprotein OS=Simian foamy virus (isolate chimpanzee) GN=pol PE=3 SV=1 PF00665//PF04561//PF13683 Integrase core domain//RNA polymerase Rpb2, domain 2//Integrase core domain GO:0015074//GO:0006144//GO:0006206//GO:0006351 DNA integration//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.1701 BP_3 75.00 2.30 1864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17012 BP_3 3.00 4.04 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17014 BP_3 586.72 11.78 2692 642933768 XP_008197204.1 3022 0.0e+00 PREDICTED: WD repeat-containing protein mio-B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q802U2 1629 9.2e-180 WD repeat-containing protein mio OS=Danio rerio GN=mios PE=2 SV=1 PF00400//PF13639 WD domain, G-beta repeat//Ring finger domain -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1008 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.17015 BP_3 209.00 6.12 1938 546675918 ERL87018.1 756 2.7e-77 hypothetical protein D910_04420 [Dendroctonus ponderosae] -- -- -- -- -- K15187 MLLT1_3, ENL, AF9 YEATS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15187 A2AM29 455 9.0e-44 Protein AF-9 OS=Mus musculus GN=Mllt3 PE=1 SV=1 PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG3149 Transcription initiation factor IIF, auxiliary subunit Cluster-8309.17019 BP_3 224.94 3.26 3619 642916541 XP_008191622.1 835 3.5e-86 PREDICTED: E3 ubiquitin-protein ligase E3D [Tribolium castaneum] -- -- -- -- -- K12584 DCPS, DCS m7GpppX diphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K12584 D3K0N9 494 5.0e-48 m7GpppX diphosphatase OS=Ascaris suum PE=1 SV=1 PF00910//PF05652 RNA helicase//Scavenger mRNA decapping enzyme (DcpS) N-terminal GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0016787//GO:0003723//GO:0003724 hydrolase activity//RNA binding//RNA helicase activity -- -- KOG3969 Uncharacterized conserved protein Cluster-8309.17020 BP_3 688.79 12.59 2929 642916609 XP_008191874.1 1145 3.2e-122 PREDICTED: m7GpppX diphosphatase [Tribolium castaneum] -- -- -- -- -- K12584 DCPS, DCS m7GpppX diphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K12584 D3K0N9 719 3.3e-74 m7GpppX diphosphatase OS=Ascaris suum PE=1 SV=1 PF05652 Scavenger mRNA decapping enzyme (DcpS) N-terminal GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0016787 hydrolase activity -- -- KOG3969 Uncharacterized conserved protein Cluster-8309.17021 BP_3 197.00 17.58 832 91076396 XP_969017.1 648 3.9e-65 PREDICTED: 39S ribosomal protein L43, mitochondrial [Tribolium castaneum]>gi|642912312|ref|XP_008200645.1| PREDICTED: 39S ribosomal protein L43, mitochondrial [Tribolium castaneum]>gi|270002560|gb|EEZ99007.1| hypothetical protein TcasGA2_TC004871 [Tribolium castaneum] -- -- -- -- -- K17424 MRPL43 large subunit ribosomal protein L43 http://www.genome.jp/dbget-bin/www_bget?ko:K17424 Q99N89 262 9.3e-22 39S ribosomal protein L43, mitochondrial OS=Mus musculus GN=Mrpl43 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3445 Mitochondrial/chloroplast ribosomal protein 36a Cluster-8309.17023 BP_3 57.85 2.41 1447 827547769 XP_012546165.1 265 1.8e-20 PREDICTED: uncharacterized protein LOC101737154 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01531//PF03849 Glycosyl transferase family 11//Transcription factor Tfb2 GO:0009247//GO:0006289//GO:0005975//GO:0001575 glycolipid biosynthetic process//nucleotide-excision repair//carbohydrate metabolic process//globoside metabolic process GO:0004003//GO:0008107 ATP-dependent DNA helicase activity//galactoside 2-alpha-L-fucosyltransferase activity GO:0016020//GO:0000439//GO:0005634//GO:0005657 membrane//core TFIIH complex//nucleus//replication fork -- -- Cluster-8309.17024 BP_3 74.00 1.58 2552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17025 BP_3 106.00 3.22 1877 642936400 XP_972145.2 626 3.1e-62 PREDICTED: 23 kDa integral membrane protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XSK2 270 2.5e-22 CD63 antigen OS=Bos taurus GN=CD63 PE=2 SV=4 PF07415//PF00335 Gammaherpesvirus latent membrane protein (LMP2) protein//Tetraspanin family GO:0019042 viral latency -- -- GO:0033644//GO:0016021 host cell membrane//integral component of membrane -- -- Cluster-8309.17026 BP_3 11.90 3.34 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05297 Herpesvirus latent membrane protein 1 (LMP1) GO:0019087 transformation of host cell by virus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17028 BP_3 1.08 0.50 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17029 BP_3 281.78 4.21 3521 478252986 ENN73368.1 2585 4.1e-289 hypothetical protein YQE_10018, partial [Dendroctonus ponderosae] 847107195 XM_012958238.1 37 4.31609e-07 PREDICTED: Xenopus (Silurana) tropicalis piwi-like RNA-mediated gene silencing 4 (piwil4), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 Q7PLK0 1621 1.0e-178 Protein argonaute-3 OS=Drosophila melanogaster GN=AGO3 PE=1 SV=3 PF02170//PF02171 PAZ domain//Piwi domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.1703 BP_3 57.35 0.79 3792 270016381 EFA12827.1 2161 6.4e-240 hypothetical protein TcasGA2_TC015879 [Tribolium castaneum] -- -- -- -- -- K19398 BBS9 Bardet-Biedl syndrome 9 protein http://www.genome.jp/dbget-bin/www_bget?ko:K19398 Q6AX60 1271 4.2e-138 Protein PTHB1 OS=Xenopus laevis GN=bbs9 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3679 Predicted coiled-coil protein Cluster-8309.17030 BP_3 27.58 0.65 2326 270010424 EFA06872.1 2219 7.4e-247 hypothetical protein TcasGA2_TC009817 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 1009 6.2e-108 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17031 BP_3 2.00 0.71 427 642939529 XP_008195687.1 211 9.5e-15 PREDICTED: uncharacterized protein LOC103313643, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17034 BP_3 1.00 6.33 256 338224440 AEI88098.1 266 2.4e-21 myosin [Scylla paramamosain] 338224439 HM217866.1 91 2.64952e-38 Scylla paramamosain isolate 1 myosin mRNA, partial cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 202 2.6e-15 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex -- -- Cluster-8309.17036 BP_3 63.19 0.56 5748 642928221 XP_008195493.1 1446 7.9e-157 PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928223|ref|XP_008195494.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928225|ref|XP_008195495.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928227|ref|XP_008195496.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum] 642928222 XM_008197272.1 209 1.7195e-102 PREDICTED: Tribolium castaneum uncharacterized LOC103313600 (LOC103313600), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF11857 Domain of unknown function (DUF3377) -- -- GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.17040 BP_3 13.60 0.46 1708 642935405 XP_008197997.1 517 1.2e-49 PREDICTED: tumor protein p63-regulated gene 1-like protein isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0D9 197 6.5e-14 Tumor protein p63-regulated gene 1-like protein OS=Homo sapiens GN=TPRG1L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17042 BP_3 1.00 0.44 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17046 BP_3 2.00 0.72 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17050 BP_3 10.00 1.77 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17055 BP_3 1.00 11.75 239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17056 BP_3 10.28 0.64 1064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17060 BP_3 2.00 0.45 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17062 BP_3 127.00 1.90 3507 189234499 XP_001812694.1 1439 3.1e-156 PREDICTED: vasorin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 280 3.2e-23 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.17063 BP_3 88.13 0.60 7374 642911815 XP_008200755.1 5961 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 611 2.8e-61 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17064 BP_3 3.00 0.41 645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17067 BP_3 16.86 0.96 1140 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17071 BP_3 17.65 0.82 1326 642928783 XP_966475.2 331 3.6e-28 PREDICTED: uncharacterized protein LOC654941 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16641 HDGF hepatoma-derived growth factor http://www.genome.jp/dbget-bin/www_bget?ko:K16641 Q32N87 185 1.2e-12 Hepatoma-derived growth factor-related protein 2 OS=Xenopus laevis GN=hdgfrp2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1904 Transcription coactivator Cluster-8309.17073 BP_3 185.12 2.66 3640 91090486 XP_968848.1 739 4.8e-75 PREDICTED: GTP-binding protein Di-Ras2 [Tribolium castaneum]>gi|270013863|gb|EFA10311.1| hypothetical protein TcasGA2_TC012527 [Tribolium castaneum] 642935350 XM_963755.2 98 5.4949e-41 PREDICTED: Tribolium castaneum GTP-binding protein Di-Ras2 (LOC657287), mRNA K07841 DIRAS2 DIRAS family, GTP-binding Ras-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07841 Q95KD9 516 1.4e-50 GTP-binding protein Di-Ras2 OS=Macaca fascicularis GN=DIRAS2 PE=2 SV=1 PF01926//PF01637//PF03193//PF08477//PF00071//PF00025 50S ribosome-binding GTPase//Archaeal ATPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.17074 BP_3 164.34 3.07 2876 91090486 XP_968848.1 739 3.8e-75 PREDICTED: GTP-binding protein Di-Ras2 [Tribolium castaneum]>gi|270013863|gb|EFA10311.1| hypothetical protein TcasGA2_TC012527 [Tribolium castaneum] 642935350 XM_963755.2 98 4.33005e-41 PREDICTED: Tribolium castaneum GTP-binding protein Di-Ras2 (LOC657287), mRNA K07841 DIRAS2 DIRAS family, GTP-binding Ras-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07841 Q95KD9 516 1.1e-50 GTP-binding protein Di-Ras2 OS=Macaca fascicularis GN=DIRAS2 PE=2 SV=1 PF03193//PF08477//PF01637//PF01926//PF00025//PF00071 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//Archaeal ATPase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.17075 BP_3 66.00 1.27 2788 642927384 XP_008195248.1 595 1.8e-58 PREDICTED: leucine-rich repeat-containing protein 40-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17078 BP_3 244.68 22.84 808 91088777 XP_967353.1 359 1.2e-31 PREDICTED: protein phosphatase 1 regulatory subunit 16A [Tribolium castaneum]>gi|270011631|gb|EFA08079.1| hypothetical protein TcasGA2_TC005675 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17079 BP_3 32.37 0.71 2484 642915789 XP_008200078.1 1481 3.0e-161 PREDICTED: uncharacterized protein LOC103314831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.1708 BP_3 2.00 0.33 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17080 BP_3 101.77 1.62 3321 642915789 XP_008200078.1 1037 1.2e-109 PREDICTED: uncharacterized protein LOC103314831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.17083 BP_3 7.00 3.54 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17084 BP_3 292.00 13.57 1329 642928651 XP_008199722.1 634 2.6e-63 PREDICTED: hemK methyltransferase family member 2 [Tribolium castaneum] -- -- -- -- -- K19589 N6AMT1 release factor glutamine methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K19589 Q9Y5N5 411 7.8e-39 HemK methyltransferase family member 2 OS=Homo sapiens GN=N6AMT1 PE=1 SV=3 PF05175//PF08241//PF06160//PF16740//PF01624//PF08165//PF08702 Methyltransferase small domain//Methyltransferase domain//Septation ring formation regulator, EzrA//Spindle and kinetochore-associated protein 2//MutS domain I//FerA (NUC095) domain//Fibrinogen alpha/beta chain family GO:0031110//GO:0051301//GO:0007067//GO:0000090//GO:0007059//GO:0007165//GO:0051258//GO:0030168//GO:0006298//GO:0008152//GO:0000921 regulation of microtubule polymerization or depolymerization//cell division//mitotic nuclear division//mitotic anaphase//chromosome segregation//signal transduction//protein polymerization//platelet activation//mismatch repair//metabolic process//septin ring assembly GO:0030983//GO:0005102//GO:0008168//GO:0005524//GO:0008017//GO:0030674 mismatched DNA binding//receptor binding//methyltransferase activity//ATP binding//microtubule binding//protein binding, bridging GO:0005577//GO:0005876//GO:0016021//GO:0045298//GO:0005940//GO:0000940 fibrinogen complex//spindle microtubule//integral component of membrane//tubulin complex//septin ring//condensed chromosome outer kinetochore KOG3191 Predicted N6-DNA-methyltransferase Cluster-8309.17086 BP_3 112.00 6.33 1145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17087 BP_3 8.00 2.36 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17090 BP_3 8.00 1.03 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17091 BP_3 147.87 1.29 5826 189237499 XP_971802.2 3233 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007691|gb|EFA04139.1| hypothetical protein TcasGA2_TC014383 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1139 1.3e-122 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF01580//PF06414//PF00005//PF03193//PF00437//PF01350//PF01443//PF00664//PF01926//PF13304//PF08477 NB-ARC domain//FtsK/SpoIIIE family//Zeta toxin//ABC transporter//Protein of unknown function, DUF258//Type II/IV secretion system protein//Flavivirus non-structural protein NS4A//Viral (Superfamily 1) RNA helicase//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase GO:0006810//GO:0055085//GO:0016070//GO:0016032//GO:0007264 transport//transmembrane transport//RNA metabolic process//viral process//small GTPase mediated signal transduction GO:0003924//GO:0005524//GO:0042626//GO:0016301//GO:0016887//GO:0000166//GO:0043531//GO:0003677//GO:0017111//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//nucleotide binding//ADP binding//DNA binding//nucleoside-triphosphatase activity//GTP binding GO:0016021//GO:0019012 integral component of membrane//virion -- -- Cluster-8309.17092 BP_3 16.00 0.43 2073 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17093 BP_3 84.05 7.50 832 546676860 ERL87797.1 510 3.9e-49 hypothetical protein D910_05186 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6Q3F5 349 7.6e-32 SID1 transmembrane family member 1 OS=Rattus norvegicus GN=Sidt1 PE=2 SV=2 PF13965//PF07690//PF06423//PF05875 dsRNA-gated channel SID-1//Major Facilitator Superfamily//GWT1//Ceramidase GO:0006672//GO:0055085//GO:0015931//GO:0033227//GO:0006807//GO:0006506 ceramide metabolic process//transmembrane transport//nucleobase-containing compound transport//dsRNA transport//nitrogen compound metabolic process//GPI anchor biosynthetic process GO:0016746//GO:0016811//GO:0051033 transferase activity, transferring acyl groups//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//RNA transmembrane transporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.17097 BP_3 14.61 0.40 2032 209418846 ACI46638.1 1944 5.0e-215 serine proteinase [Portunus trituberculatus] 209418845 FJ360742.1 1137 0 Portunus trituberculatus strain LZW serine proteinase (SP) mRNA, complete cds K01316 PRSS7 protease, serine, 7 (enterokinase) http://www.genome.jp/dbget-bin/www_bget?ko:K01316 P21902 538 2.2e-53 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.17100 BP_3 136.57 7.35 1187 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17102 BP_3 24.30 0.44 2926 642927837 XP_008195420.1 555 8.4e-54 PREDICTED: HSPB1-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19375 HSPBAP1 HSPB1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19375 Q6AXL5 257 1.2e-20 HSPB1-associated protein 1 homolog OS=Danio rerio GN=hspbap1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.17103 BP_3 162.31 3.32 2650 91086211 XP_971977.1 943 7.7e-99 PREDICTED: HSPB1-associated protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19375 HSPBAP1 HSPB1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19375 Q96EW2 492 6.3e-48 HSPB1-associated protein 1 OS=Homo sapiens GN=HSPBAP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.17112 BP_3 269.53 8.76 1775 91088521 XP_971980.1 407 7.4e-37 PREDICTED: protein drumstick isoform X2 [Tribolium castaneum]>gi|270012231|gb|EFA08679.1| hypothetical protein TcasGA2_TC006347 [Tribolium castaneum] -- -- -- -- -- K09215 OSR, ODD odd-skipped http://www.genome.jp/dbget-bin/www_bget?ko:K09215 Q7PN68 392 1.7e-36 Protein drumstick OS=Anopheles gambiae GN=drm PE=3 SV=1 PF13465//PF00096//PF01155//PF13912//PF00643//PF02892//PF00412 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//C2H2-type zinc finger//B-box zinc finger//BED zinc finger//LIM domain GO:0006464 cellular protein modification process GO:0046872//GO:0016151//GO:0003677//GO:0003676//GO:0008270 metal ion binding//nickel cation binding//DNA binding//nucleic acid binding//zinc ion binding GO:0005622 intracellular KOG1721 FOG: Zn-finger Cluster-8309.17113 BP_3 168.11 3.46 2634 270001924 EEZ98371.1 967 1.3e-101 hypothetical protein TcasGA2_TC000830 [Tribolium castaneum] 194742811 XM_001953858.1 123 5.01989e-55 Drosophila ananassae GF17008 (Dana\GF17008), mRNA -- -- -- -- Q68DU8 428 1.7e-40 BTB/POZ domain-containing protein KCTD16 OS=Homo sapiens GN=KCTD16 PE=2 SV=1 PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- KOG2723 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.17114 BP_3 20.29 0.76 1581 662192693 XP_008469216.1 322 4.7e-27 PREDICTED: uncharacterized protein LOC103506596 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.17117 BP_3 129.00 4.68 1621 167234380 NP_001107813.1 1053 8.3e-112 glass bottom boat protein precursor [Tribolium castaneum]>gi|270008197|gb|EFA04645.1| glass bottom boat [Tribolium castaneum] 645016200 XM_001603826.3 83 5.27313e-33 PREDICTED: Nasonia vitripennis protein 60A (LOC100120216), mRNA K16621 BMP7 bone morphogenetic protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K16621 Q24735 837 3.8e-88 Protein 60A OS=Drosophila virilis GN=gbb PE=3 SV=1 PF00688//PF00019 TGF-beta propeptide//Transforming growth factor beta like domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.17118 BP_3 23.57 0.49 2630 478263077 ENN81477.1 220 5.3e-15 hypothetical protein YQE_02169, partial [Dendroctonus ponderosae]>gi|546682119|gb|ERL92100.1| hypothetical protein D910_09421 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17123 BP_3 66.00 1.62 2254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17124 BP_3 55.26 1.57 1983 478252725 ENN73120.1 1528 8.5e-167 hypothetical protein YQE_10261, partial [Dendroctonus ponderosae] -- -- -- -- -- K18398 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18398 Q0VA77 603 6.3e-61 Bis(5'-adenosyl)-triphosphatase enpp4 OS=Xenopus tropicalis GN=enpp4 PE=2 SV=1 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase -- -- GO:0003824 catalytic activity -- -- KOG2645 Type I phosphodiesterase/nucleotide pyrophosphatase Cluster-8309.1713 BP_3 64.50 1.18 2918 667310568 XP_008584447.1 587 1.6e-57 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like [Galeopterus variegatus] 817185122 XM_012429711.1 90 1.23039e-36 PREDICTED: Orussus abietinus B-cell lymphoma 6 protein (LOC105702268), mRNA -- -- -- -- Q6ZMW2 552 7.7e-55 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF01428//PF00651//PF13912//PF07975//PF13465//PF03931//PF01155//PF00096 AN1-like Zinc finger//BTB/POZ domain//C2H2-type zinc finger//TFIIH C1-like domain//Zinc-finger double domain//Skp1 family, tetramerisation domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type GO:0006281//GO:0006464//GO:0006511 DNA repair//cellular protein modification process//ubiquitin-dependent protein catabolic process GO:0005515//GO:0046872//GO:0016151//GO:0008270 protein binding//metal ion binding//nickel cation binding//zinc ion binding -- -- -- -- Cluster-8309.17131 BP_3 75.28 2.28 1882 51102795 AAT95992.1 450 8.1e-42 transposase [Drosophila willistoni]>gi|51102803|gb|AAT95996.1| transposase [Drosophila willistoni] -- -- -- -- -- -- -- -- -- Q7M3K2 446 9.6e-43 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF04977//PF05531//PF02689 Septum formation initiator//Nucleopolyhedrovirus P10 protein//Helicase GO:0007049 cell cycle GO:0005524//GO:0004386 ATP binding//helicase activity GO:0019028 viral capsid -- -- Cluster-8309.17132 BP_3 66.82 2.52 1568 91085557 XP_966821.1 810 1.2e-83 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 319 4.3e-28 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13371//PF13181//PF00515//PF13414//PF00254//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.17136 BP_3 1771.83 10.30 8584 478255227 ENN75456.1 9118 0.0e+00 hypothetical protein YQE_08006, partial [Dendroctonus ponderosae] 759045107 XM_011333192.1 97 4.68543e-40 PREDICTED: Cerapachys biroi protein sidekick (LOC105275958), transcript variant X4, mRNA K16353 SDK protein sidekick http://www.genome.jp/dbget-bin/www_bget?ko:K16353 O97394 7458 0.0e+00 Protein sidekick OS=Drosophila melanogaster GN=sdk PE=1 SV=2 PF07646//PF02404//PF16656//PF07354//PF13895//PF00041 Kelch motif//Stem cell factor//Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0007339//GO:0007165//GO:0006771//GO:0007155 hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//signal transduction//riboflavin metabolic process//cell adhesion GO:0005515//GO:0005173//GO:0046872//GO:0003993 protein binding//stem cell factor receptor binding//metal ion binding//acid phosphatase activity GO:0016020//GO:0005576 membrane//extracellular region KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.17139 BP_3 1129.27 21.51 2822 236468408 NP_001153625.1 1219 8.2e-131 spaetzle 3 [Tribolium castaneum] 817194790 XM_012417488.1 155 8.75045e-73 PREDICTED: Orussus abietinus uncharacterized LOC105695690 (LOC105695690), mRNA -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.17141 BP_3 3183.61 144.59 1353 478259252 ENN79154.1 861 1.3e-89 hypothetical protein YQE_04340, partial [Dendroctonus ponderosae]>gi|546678412|gb|ERL89035.1| hypothetical protein D910_06413 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y2C2 296 1.7e-25 Uronyl 2-sulfotransferase OS=Homo sapiens GN=UST PE=2 SV=1 PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane KOG3922 Sulfotransferases Cluster-8309.17143 BP_3 14.00 0.96 995 478256535 ENN76719.1 437 1.4e-40 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 334 5.0e-30 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13912//PF16622//PF13465//PF05864//PF00518//PF06467//PF00096//PF02176 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Early Protein (E6)//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C2H2 type//TRAF-type zinc finger GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0042025 nucleolus//host cell nucleus -- -- Cluster-8309.17146 BP_3 18.76 0.36 2808 478254283 ENN74537.1 2872 0.0e+00 hypothetical protein YQE_08860, partial [Dendroctonus ponderosae] 746860322 XM_011062696.1 135 1.1423e-61 PREDICTED: Acromyrmex echinatior exportin-2 (LOC105149943), mRNA K18423 CSE1, CAS, XPO2 exportin-2 (importin alpha re-exporter) http://www.genome.jp/dbget-bin/www_bget?ko:K18423 Q9XZU1 2275 1.2e-254 Exportin-2 OS=Drosophila melanogaster GN=Cas PE=2 SV=2 PF03810//PF03378//PF08506//PF00514 Importin-beta N-terminal domain//CAS/CSE protein, C-terminus//Cse1//Armadillo/beta-catenin-like repeat GO:0006886 intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding -- -- KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily) Cluster-8309.17148 BP_3 5.00 1.02 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1715 BP_3 34.42 0.63 2906 667310568 XP_008584447.1 587 1.6e-57 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like [Galeopterus variegatus] 817185122 XM_012429711.1 87 5.70063e-35 PREDICTED: Orussus abietinus B-cell lymphoma 6 protein (LOC105702268), mRNA -- -- -- -- Q5JVG2 552 7.6e-55 Zinc finger protein 484 OS=Homo sapiens GN=ZNF484 PE=1 SV=1 PF07975//PF13465//PF01428//PF00651//PF13912//PF01155//PF03931//PF00096 TFIIH C1-like domain//Zinc-finger double domain//AN1-like Zinc finger//BTB/POZ domain//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Skp1 family, tetramerisation domain//Zinc finger, C2H2 type GO:0006281//GO:0006464//GO:0006511 DNA repair//cellular protein modification process//ubiquitin-dependent protein catabolic process GO:0016151//GO:0046872//GO:0005515//GO:0008270 nickel cation binding//metal ion binding//protein binding//zinc ion binding -- -- -- -- Cluster-8309.17153 BP_3 10.92 2.56 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17155 BP_3 202.89 9.31 1342 91085455 XP_969485.1 152 2.1e-07 PREDICTED: WASH complex subunit FAM21A [Tribolium castaneum]>gi|270009171|gb|EFA05619.1| hypothetical protein TcasGA2_TC015827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17156 BP_3 154.74 3.82 2245 91083281 XP_974400.1 2039 5.4e-226 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|270007725|gb|EFA04173.1| hypothetical protein TcasGA2_TC014422 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.17158 BP_3 412.05 6.39 3398 642923271 XP_008193684.1 3688 0.0e+00 PREDICTED: protein FAN-like [Tribolium castaneum]>gi|642923273|ref|XP_008193685.1| PREDICTED: protein FAN-like [Tribolium castaneum] -- -- -- -- -- K18953 NSMAF, FAN factor associated with neutral sphingomyelinase activation http://www.genome.jp/dbget-bin/www_bget?ko:K18953 Q92636 1606 5.4e-177 Protein FAN OS=Homo sapiens GN=NSMAF PE=1 SV=2 PF00400//PF11605//PF16836//PF07569 WD domain, G-beta repeat//Vacuolar protein sorting protein 36 Vps36//Shu complex component Psy3, DNA-binding description//TUP1-like enhancer of split GO:0006355//GO:0000725 regulation of transcription, DNA-templated//recombinational repair GO:0043130//GO:0032266//GO:0005515 ubiquitin binding//phosphatidylinositol-3-phosphate binding//protein binding GO:0005634//GO:0097196 nucleus//Shu complex KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.17161 BP_3 168.85 6.43 1558 646700550 KDR10660.1 1207 1.1e-129 Cyclin-C [Zootermopsis nevadensis] -- -- -- -- -- K15161 CCNC, SSN8 cyclin C http://www.genome.jp/dbget-bin/www_bget?ko:K15161 Q7QB13 1193 1.9e-129 Cyclin-C OS=Anopheles gambiae GN=CycC PE=3 SV=2 PF00382//PF02984 Transcription factor TFIIB repeat//Cyclin, C-terminal domain -- -- GO:0017025 TBP-class protein binding GO:0005634 nucleus KOG0794 CDK8 kinase-activating protein cyclin C Cluster-8309.17162 BP_3 10.00 1.44 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09034 TRADD, N-terminal domain GO:0043123//GO:0007165 positive regulation of I-kappaB kinase/NF-kappaB signaling//signal transduction GO:0005515//GO:0004871 protein binding//signal transducer activity -- -- -- -- Cluster-8309.17164 BP_3 261.00 3.40 3996 642928273 XP_008195514.1 2990 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: pikachurin [Tribolium castaneum] 815825151 XM_012378522.1 67 1.03199e-23 PREDICTED: Linepithema humile pikachurin (LOC105678841), mRNA -- -- -- -- Q63HQ2 1013 3.7e-108 Pikachurin OS=Homo sapiens GN=EGFLAM PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.17167 BP_3 14.32 0.31 2501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17171 BP_3 80.54 3.59 1372 270015435 EFA11883.1 715 1.1e-72 hypothetical protein TcasGA2_TC004298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17174 BP_3 13.00 0.71 1174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17178 BP_3 5.70 0.49 855 270016365 EFA12811.1 175 2.8e-10 hypothetical protein TcasGA2_TC001876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17179 BP_3 9.03 0.79 840 478262128 ENN81013.1 174 3.6e-10 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17180 BP_3 19.00 0.80 1435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17182 BP_3 31.78 0.78 2268 189234066 XP_970272.2 1149 8.6e-123 PREDICTED: calcium uptake protein 3, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CTY5 569 6.4e-57 Calcium uptake protein 3, mitochondrial OS=Mus musculus GN=Micu3 PE=2 SV=2 PF13833//PF13405//PF00036//PF13499//PF13202//PF12763 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.17188 BP_3 366.11 12.59 1693 642915761 XP_008200069.1 1878 1.9e-207 PREDICTED: cleft lip and palate transmembrane protein 1-like protein [Tribolium castaneum]>gi|642915763|ref|XP_008200070.1| PREDICTED: cleft lip and palate transmembrane protein 1-like protein [Tribolium castaneum]>gi|270003133|gb|EEZ99580.1| hypothetical protein TcasGA2_TC001566 [Tribolium castaneum] 752401280 XM_002918833.2 123 3.20238e-55 PREDICTED: Ailuropoda melanoleuca CLPTM1-like (CLPTM1L), transcript variant X2, mRNA -- -- -- -- Q5ZKJ0 1136 8.5e-123 Cleft lip and palate transmembrane protein 1-like protein OS=Gallus gallus GN=CLPTM1L PE=2 SV=1 PF09268//PF05602//PF03104 Clathrin, heavy-chain linker//Cleft lip and palate transmembrane protein 1 (CLPTM1)//DNA polymerase family B, exonuclease domain GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008408//GO:0005198 3'-5' exonuclease activity//structural molecule activity GO:0030132//GO:0016021//GO:0030130 clathrin coat of coated pit//integral component of membrane//clathrin coat of trans-Golgi network vesicle KOG2489 Transmembrane protein Cluster-8309.17189 BP_3 4.00 0.54 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17191 BP_3 12.14 1.22 772 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225 helix-turn-helix, Psq domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.17192 BP_3 19.00 1.52 895 307178776 EFN67382.1 362 6.1e-32 Transposable element Tc3 transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17193 BP_3 20.00 2.15 740 861617233 KMQ86537.1 348 2.1e-30 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17194 BP_3 108.71 3.66 1725 91082813 XP_968677.1 1380 1.1e-149 PREDICTED: transmembrane protein 43 homolog [Tribolium castaneum]>gi|270007099|gb|EFA03547.1| hypothetical protein TcasGA2_TC013551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSB9 769 3.1e-80 Transmembrane protein 43 homolog OS=Drosophila melanogaster GN=CG8111 PE=2 SV=1 PF15184 Mitochondrial import receptor subunit TOM6 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.17197 BP_3 178.59 48.75 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08430//PF07810 Forkhead N-terminal region//TMC domain -- -- GO:0019904//GO:0008134 protein domain specific binding//transcription factor binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.17199 BP_3 29.51 0.42 3691 478257569 ENN77723.1 257 3.8e-19 hypothetical protein YQE_05794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17200 BP_3 2087.00 115.06 1166 332374402 AEE62342.1 443 3.2e-41 unknown [Dendroctonus ponderosae]>gi|478259316|gb|ENN79218.1| hypothetical protein YQE_04402, partial [Dendroctonus ponderosae]>gi|546675054|gb|ERL86309.1| hypothetical protein D910_03717 [Dendroctonus ponderosae] 153928954 AK284256.1 122 7.85683e-55 Gryllus bimaculatus mRNA, GBcontig31117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17201 BP_3 35.21 0.55 3361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17203 BP_3 13.00 0.36 2048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17207 BP_3 24.07 1.92 897 546683481 ERL93287.1 872 4.5e-91 hypothetical protein D910_10583 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P3S1 547 8.9e-55 DENN domain-containing protein 1B OS=Homo sapiens GN=DENND1B PE=1 SV=1 PF00787//PF06144 PX domain//DNA polymerase III, delta subunit GO:0006260 DNA replication GO:0003677//GO:0035091//GO:0003887 DNA binding//phosphatidylinositol binding//DNA-directed DNA polymerase activity GO:0009360//GO:0042575 DNA polymerase III complex//DNA polymerase complex KOG3569 RAS signaling inhibitor ST5 Cluster-8309.17210 BP_3 84.00 3.67 1394 478255359 ENN75585.1 589 4.6e-58 hypothetical protein YQE_07928, partial [Dendroctonus ponderosae] -- -- -- -- -- K17619 MDP1 magnesium-dependent phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17619 Q9D967 463 7.6e-45 Magnesium-dependent phosphatase 1 OS=Mus musculus GN=Mdp1 PE=1 SV=1 PF04551//PF12689 GcpE protein//Acid Phosphatase GO:0016114//GO:0055114 terpenoid biosynthetic process//oxidation-reduction process GO:0046429//GO:0016791 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//phosphatase activity -- -- KOG4549 Magnesium-dependent phosphatase Cluster-8309.17212 BP_3 22.00 8.34 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17215 BP_3 30.88 1.15 1589 478250608 ENN71100.1 1363 9.2e-148 hypothetical protein YQE_12033, partial [Dendroctonus ponderosae] -- -- -- -- -- K02328 POLD2 DNA polymerase delta subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02328 Q9W088 751 3.5e-78 DNA polymerase delta small subunit OS=Drosophila melanogaster GN=CG12018 PE=2 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG2732 DNA polymerase delta, regulatory subunit 55 Cluster-8309.17220 BP_3 21.87 0.48 2511 642928781 XP_008195560.1 1001 1.4e-105 PREDICTED: uncharacterized protein LOC654941 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75475 193 2.8e-13 PC4 and SFRS1-interacting protein OS=Homo sapiens GN=PSIP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1904 Transcription coactivator Cluster-8309.17221 BP_3 71.84 6.83 799 189233768 XP_001814337.1 458 4.0e-43 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 330 1.2e-29 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086//PF01529 Jagunal, ER re-organisation during oogenesis//DHHC palmitoyltransferase GO:0007029 endoplasmic reticulum organization GO:0008270 zinc ion binding GO:0005789 endoplasmic reticulum membrane KOG4054 Uncharacterized conserved protein Cluster-8309.17222 BP_3 67.39 3.49 1222 189233768 XP_001814337.1 678 1.9e-68 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 517 3.7e-51 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086 Jagunal, ER re-organisation during oogenesis GO:0007029 endoplasmic reticulum organization -- -- GO:0005789 endoplasmic reticulum membrane KOG4054 Uncharacterized conserved protein Cluster-8309.17223 BP_3 2.78 0.34 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17224 BP_3 1086.58 6.80 7990 546671878 ERL83997.1 3673 0.0e+00 hypothetical protein D910_01313 [Dendroctonus ponderosae]>gi|546679661|gb|ERL90088.1| hypothetical protein D910_07442 [Dendroctonus ponderosae] -- -- -- -- -- K17935 SNX29 sorting nexin-29 http://www.genome.jp/dbget-bin/www_bget?ko:K17935 Q9VKB9 1413 3.0e-154 Rab3 GTPase-activating protein regulatory subunit OS=Drosophila melanogaster GN=rab3-GAP PE=1 SV=2 PF00787//PF04977//PF00957 PX domain//Septum formation initiator//Synaptobrevin GO:0016192//GO:0007049 vesicle-mediated transport//cell cycle GO:0035091 phosphatidylinositol binding GO:0016021 integral component of membrane KOG2727 Rab3 GTPase-activating protein, non-catalytic subunit Cluster-8309.17230 BP_3 13.43 0.93 989 270012927 EFA09375.1 198 7.0e-13 hypothetical protein TcasGA2_TC001936 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17234 BP_3 267.00 7.18 2083 478254355 ENN74607.1 415 1.0e-37 hypothetical protein YQE_08728, partial [Dendroctonus ponderosae]>gi|546677887|gb|ERL88637.1| hypothetical protein D910_06021 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28DG6 138 5.5e-07 LysM and putative peptidoglycan-binding domain-containing protein 3 OS=Xenopus tropicalis GN=lysmd3 PE=2 SV=1 PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17239 BP_3 12.00 5.89 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1724 BP_3 9.14 0.35 1551 642912712 XP_008200971.1 1066 2.5e-113 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642912714|ref|XP_008200972.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q99NH7 410 1.2e-38 Prestin OS=Mus musculus GN=Slc26a5 PE=2 SV=3 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.17240 BP_3 94.68 2.97 1830 642923010 XP_973133.3 1144 2.6e-122 PREDICTED: transcription factor GATA-4-like isoform X1 [Tribolium castaneum] 795168618 XM_011942824.1 82 2.14648e-32 PREDICTED: Colobus angolensis palliatus GATA binding protein 4 (GATA4), mRNA K17896 GATA5 GATA-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17896 P43695 557 1.3e-55 GATA-binding factor 5-A OS=Xenopus laevis GN=gata5-a PE=2 SV=1 PF01412//PF01873//PF00320//PF08273//PF08752 Putative GTPase activating protein for Arf//Domain found in IF2B/IF5//GATA zinc finger//Zinc-binding domain of primase-helicase//Coatomer gamma subunit appendage platform subdomain GO:0006886//GO:0016192//GO:0006269//GO:0006355//GO:0006351//GO:0006446//GO:0006413 intracellular protein transport//vesicle-mediated transport//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//transcription, DNA-templated//regulation of translational initiation//translational initiation GO:0003896//GO:0005096//GO:0003743//GO:0005198//GO:0043565//GO:0008270//GO:0003700//GO:0004386 DNA primase activity//GTPase activator activity//translation initiation factor activity//structural molecule activity//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//helicase activity GO:0030126//GO:0005840//GO:0005730//GO:0005657//GO:0005667 COPI vesicle coat//ribosome//nucleolus//replication fork//transcription factor complex KOG1601 GATA-4/5/6 transcription factors Cluster-8309.17249 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17251 BP_3 29.67 1.94 1028 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17256 BP_3 26.00 0.94 1622 642919519 XP_008191907.1 1136 2.0e-121 PREDICTED: transposon Ty3-G Gag-Pol polyprotein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O93209 301 5.4e-26 Pro-Pol polyprotein OS=Feline foamy virus GN=pol PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.17258 BP_3 230.76 1.79 6502 478251982 ENN72418.1 2890 0.0e+00 hypothetical protein YQE_10936, partial [Dendroctonus ponderosae] 562831337 XM_006145090.1 42 1.32995e-09 PREDICTED: Tupaia chinensis tripartite motif containing 24 (TRIM24), mRNA K08883 TRIM33, TIF1G tripartite motif-containing protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K08883 Q6E2N3 401 5.5e-37 E3 ubiquitin-protein ligase TRIM33 OS=Danio rerio GN=trim33 PE=2 SV=1 PF00439//PF00097//PF00643//PF14634//PF00628//PF13639//PF16685//PF01361//PF04810 Bromodomain//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger//zinc-RING finger domain//PHD-finger//Ring finger domain//zinc RING finger of MSL2//Tautomerase enzyme//Sec23/Sec24 zinc finger GO:0006725//GO:0006886//GO:0006888 cellular aromatic compound metabolic process//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515//GO:0016853//GO:0061630 zinc ion binding//metal ion binding//protein binding//isomerase activity//ubiquitin protein ligase activity GO:0005622//GO:0030127 intracellular//COPII vesicle coat -- -- Cluster-8309.17259 BP_3 105.17 1.26 4299 478251982 ENN72418.1 3317 0.0e+00 hypothetical protein YQE_10936, partial [Dendroctonus ponderosae] 562831337 XM_006145090.1 42 8.7724e-10 PREDICTED: Tupaia chinensis tripartite motif containing 24 (TRIM24), mRNA K08883 TRIM33, TIF1G tripartite motif-containing protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K08883 Q56R14 487 3.9e-47 E3 ubiquitin-protein ligase TRIM33 OS=Xenopus laevis GN=trim33 PE=1 SV=1 PF01361//PF00324//PF13639//PF00097//PF14634//PF00628//PF00643//PF00439 Tautomerase enzyme//Amino acid permease//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//PHD-finger//B-box zinc finger//Bromodomain GO:0055085//GO:0006810//GO:0006725 transmembrane transport//transport//cellular aromatic compound metabolic process GO:0005515//GO:0016853//GO:0008270//GO:0046872 protein binding//isomerase activity//zinc ion binding//metal ion binding GO:0016020//GO:0005622 membrane//intracellular -- -- Cluster-8309.1726 BP_3 53.72 1.92 1638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17262 BP_3 6.55 0.31 1326 546679847 ERL90235.1 751 7.1e-77 hypothetical protein D910_07588 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q09024 285 3.2e-24 Neural/ectodermal development factor IMP-L2 OS=Drosophila melanogaster GN=ImpL2 PE=1 SV=4 PF07354//PF13895 Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain GO:0007339 binding of sperm to zona pellucida GO:0005515 protein binding GO:0005576 extracellular region KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.17263 BP_3 47.45 2.73 1131 546679847 ERL90235.1 751 6.1e-77 hypothetical protein D910_07588 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q09024 285 2.7e-24 Neural/ectodermal development factor IMP-L2 OS=Drosophila melanogaster GN=ImpL2 PE=1 SV=4 PF13895//PF07354 Immunoglobulin domain//Zona-pellucida-binding protein (Sp38) GO:0007339 binding of sperm to zona pellucida GO:0005515 protein binding GO:0005576 extracellular region KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.17264 BP_3 2.00 0.31 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17266 BP_3 39.18 2.25 1131 642924008 XP_008193967.1 613 6.1e-61 PREDICTED: ran-binding protein 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P69566 243 2.0e-19 Ran-binding protein 9 OS=Mus musculus GN=Ranbp9 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17268 BP_3 43.00 3.02 978 642939110 XP_008198338.1 163 8.0e-09 PREDICTED: uncharacterized protein LOC103314336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF02954//PF02376 Transposase//Bacterial regulatory protein, Fis family//CUT domain GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.17271 BP_3 6.52 0.38 1128 478253162 ENN73533.1 179 1.3e-10 hypothetical protein YQE_09784, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 134 8.7e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00130//PF13465//PF00096//PF13912 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger GO:0035556 intracellular signal transduction GO:0046872 metal ion binding -- -- -- -- Cluster-8309.17272 BP_3 53.83 1.10 2652 91077788 XP_969244.1 928 4.3e-97 PREDICTED: potassium channel subfamily K member 6-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K04912 KCNK1 potassium channel subfamily K member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04912 O00180 511 4.0e-50 Potassium channel subfamily K member 1 OS=Homo sapiens GN=KCNK1 PE=1 SV=1 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.17274 BP_3 104.90 1.46 3754 91085531 XP_972280.1 1554 1.6e-169 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] 695028813 XM_009403524.1 86 2.65612e-34 PREDICTED: Musa acuminata subsp. malaccensis beta-ureidopropionase-like (LOC103985725), mRNA K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q8VC97 1264 2.7e-137 Beta-ureidopropionase OS=Mus musculus GN=Upb1 PE=2 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG2648 Diphthamide biosynthesis protein Cluster-8309.17279 BP_3 39.45 0.87 2482 270007220 EFA03668.1 156 1.3e-07 hypothetical protein TcasGA2_TC013766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1728 BP_3 4.00 0.46 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17282 BP_3 54.27 0.91 3181 642922818 XP_008193338.1 1625 7.7e-178 PREDICTED: lachesin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24372 354 7.6e-32 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17283 BP_3 64.73 1.14 3040 642922822 XP_008193340.1 1534 2.6e-167 PREDICTED: neurotrimin-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99PJ0 353 9.5e-32 Neurotrimin OS=Mus musculus GN=Ntm PE=2 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17293 BP_3 111.83 1.49 3900 270014603 EFA11051.1 3543 0.0e+00 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] 195445683 XM_002070402.1 103 9.78875e-44 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2408 6.2e-270 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00041//PF00102//PF00782 Fibronectin type III domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515//GO:0008138 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.17296 BP_3 108.11 5.71 1204 189237943 XP_001811459.1 1204 1.9e-129 PREDICTED: WD repeat domain-containing protein 83 [Tribolium castaneum] -- -- -- -- -- K13124 MORG1 mitogen-activated protein kinase organizer 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13124 Q9DAJ4 791 6.1e-83 WD repeat domain-containing protein 83 OS=Mus musculus GN=Wdr83 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0316 Conserved WD40 repeat-containing protein Cluster-8309.17297 BP_3 15.18 1.06 981 91083169 XP_972121.1 340 2.4e-29 PREDICTED: uncharacterized protein LOC660825 [Tribolium castaneum]>gi|270007697|gb|EFA04145.1| hypothetical protein TcasGA2_TC014389 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13508 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.17304 BP_3 15.33 0.39 2169 617485861 XP_007577246.1 445 3.5e-41 PREDICTED: DNA excision repair protein ERCC-1 [Poecilia formosa] -- -- -- -- -- K10849 ERCC1 DNA excision repair protein ERCC-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10849 Q1LZ75 423 5.2e-40 DNA excision repair protein ERCC-1 OS=Bos taurus GN=ERCC1 PE=2 SV=1 PF01296//PF00633//PF01367//PF07690//PF10391 Galanin//Helix-hairpin-helix motif//5'-3' exonuclease, C-terminal SAM fold//Major Facilitator Superfamily//Fingers domain of DNA polymerase lambda GO:0055085//GO:0007165 transmembrane transport//signal transduction GO:0034061//GO:0005179//GO:0003677//GO:0003824 DNA polymerase activity//hormone activity//DNA binding//catalytic activity GO:0005576//GO:0005634//GO:0016021 extracellular region//nucleus//integral component of membrane KOG2841 Structure-specific endonuclease ERCC1-XPF, ERCC1 component Cluster-8309.17307 BP_3 1.00 5.54 260 307190162 EFN74290.1 181 1.7e-11 hypothetical protein EAG_12833, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17310 BP_3 57.32 1.37 2312 270003871 EFA00319.1 227 7.2e-16 hypothetical protein TcasGA2_TC003157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17311 BP_3 100.49 1.59 3347 546676453 ERL87458.1 1811 2.2e-199 hypothetical protein D910_04850 [Dendroctonus ponderosae] -- -- -- -- -- K18470 ARHGAP1, CDC42GAP Rho GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18470 Q07960 857 3.8e-90 Rho GTPase-activating protein 1 OS=Homo sapiens GN=ARHGAP1 PE=1 SV=1 PF00620//PF06151 RhoGAP domain//Trehalose receptor GO:0007607//GO:0007187//GO:0050912//GO:0007165 obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//signal transduction GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4406 CDC42 Rho GTPase-activating protein Cluster-8309.17313 BP_3 33.22 0.40 4342 546676453 ERL87458.1 1811 2.8e-199 hypothetical protein D910_04850 [Dendroctonus ponderosae] -- -- -- -- -- K18470 ARHGAP1, CDC42GAP Rho GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18470 Q07960 857 4.9e-90 Rho GTPase-activating protein 1 OS=Homo sapiens GN=ARHGAP1 PE=1 SV=1 PF00620//PF06151 RhoGAP domain//Trehalose receptor GO:0007187//GO:0050912//GO:0007165//GO:0007607 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//signal transduction//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4406 CDC42 Rho GTPase-activating protein Cluster-8309.17314 BP_3 532.10 7.61 3661 546676453 ERL87458.1 1811 2.4e-199 hypothetical protein D910_04850 [Dendroctonus ponderosae] -- -- -- -- -- K18470 ARHGAP1, CDC42GAP Rho GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18470 Q07960 857 4.1e-90 Rho GTPase-activating protein 1 OS=Homo sapiens GN=ARHGAP1 PE=1 SV=1 PF00620//PF06151 RhoGAP domain//Trehalose receptor GO:0007607//GO:0007187//GO:0050912//GO:0007165 obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//signal transduction GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4406 CDC42 Rho GTPase-activating protein Cluster-8309.17323 BP_3 24.93 0.33 3944 642937952 XP_970081.3 240 3.8e-17 PREDICTED: uncharacterized protein LOC658612 isoform X2 [Tribolium castaneum]>gi|270015689|gb|EFA12137.1| hypothetical protein TcasGA2_TC002283 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17325 BP_3 2.00 0.34 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17326 BP_3 10.58 0.34 1798 642915291 XP_008190557.1 362 1.2e-31 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8VI02 160 1.3e-09 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Rattus norvegicus GN=Ppp4r1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17328 BP_3 12.12 1.96 590 642933293 XP_968154.2 375 1.3e-33 PREDICTED: putative ribosomal RNA methyltransferase CG11447 [Tribolium castaneum] -- -- -- -- -- K02427 rlmE, rrmJ, ftsJ 23S rRNA (uridine2552-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K02427 Q9VDT6 276 1.6e-23 rRNA methyltransferase 2, mitochondrial OS=Drosophila melanogaster GN=CG11447 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ Cluster-8309.17329 BP_3 856.03 44.93 1210 91077632 XP_974008.1 1058 1.6e-112 PREDICTED: venom acid phosphatase Acph-1 [Tribolium castaneum]>gi|270002186|gb|EEZ98633.1| hypothetical protein TcasGA2_TC001160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLY5 462 8.6e-45 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.17330 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17333 BP_3 4.21 0.82 538 642926860 XP_971810.2 147 3.1e-07 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF00096 zinc-finger C2H2-type//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.17336 BP_3 81.00 2.43 1898 270012606 EFA09054.1 424 8.4e-39 hypothetical protein TcasGA2_TC006767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01698 Floricaula / Leafy protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.17340 BP_3 22.05 2.62 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17342 BP_3 2333.00 26.60 4519 642918165 XP_008191394.1 232 3.7e-16 PREDICTED: mucin-22 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17343 BP_3 2042.07 12.90 7923 642918165 XP_008191394.1 2589 3.2e-289 PREDICTED: mucin-22 isoform X4 [Tribolium castaneum] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 819 2.3e-85 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF01607//PF00704 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18 GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region -- -- Cluster-8309.17347 BP_3 295.42 3.60 4250 91089065 XP_970808.1 2413 4.3e-269 PREDICTED: protein brunelleschi [Tribolium castaneum]>gi|642932680|ref|XP_008196943.1| PREDICTED: protein brunelleschi [Tribolium castaneum]>gi|642932683|ref|XP_008196944.1| PREDICTED: protein brunelleschi [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96Q05 1060 1.4e-113 Trafficking protein particle complex subunit 9 OS=Homo sapiens GN=TRAPPC9 PE=1 SV=2 PF00515//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG1953 Targeting complex (TRAPP) subunit Cluster-8309.17348 BP_3 6.00 2.16 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17349 BP_3 16.54 1.02 1077 642926185 XP_008194821.1 484 5.3e-46 PREDICTED: deleted in azoospermia protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24207 333 7.0e-30 Protein boule OS=Drosophila melanogaster GN=bol PE=2 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.17353 BP_3 56.40 0.63 4639 91083873 XP_974306.1 619 5.0e-61 PREDICTED: uncharacterized protein LOC663153 [Tribolium castaneum]>gi|270007945|gb|EFA04393.1| hypothetical protein TcasGA2_TC014692 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70617 230 2.7e-17 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF07469//PF04923//PF01884 Domain of unknown function (DUF1518)//Ninjurin//PcrB family GO:0042246//GO:0007155 tissue regeneration//cell adhesion GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.17354 BP_3 1.00 31.22 216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17355 BP_3 11.00 1.75 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17357 BP_3 4.52 0.34 927 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17359 BP_3 1.00 0.76 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00165 Bacterial regulatory helix-turn-helix proteins, AraC family GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.1736 BP_3 1.00 0.35 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17360 BP_3 354.61 9.28 2134 546672915 ERL84631.1 1392 5.4e-151 hypothetical protein D910_02059 [Dendroctonus ponderosae] -- -- -- -- -- K03842 ALG1 beta-1,4-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03842 Q5R7A2 960 2.7e-102 Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Pongo abelii GN=ALG1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2941 Beta-1,4-mannosyltransferase Cluster-8309.17362 BP_3 3.00 3.67 320 54312039 BAD66670.1 217 1.4e-15 cecropin precursor [Acalolepta luxuriosa] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00272 Cecropin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.17364 BP_3 226.74 5.93 2136 282400160 NP_001164203.1 2814 0.0e+00 cannonball [Tribolium castaneum]>gi|270008125|gb|EFA04573.1| cannonball [Tribolium castaneum] 242007793 XM_002424662.1 201 1.77155e-98 Pediculus humanus corporis transcription initiation factor TFIID subunit, putative, mRNA K03130 TAF5 transcription initiation factor TFIID subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03130 P49846 1681 6.8e-186 Transcription initiation factor TFIID subunit 5 OS=Drosophila melanogaster GN=Taf5 PE=1 SV=1 PF00039//PF00400//PF04494 Fibronectin type I domain//WD domain, G-beta repeat//WD40 associated region in TFIID subunit, NTD2 domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005576//GO:0005634 extracellular region//nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.17365 BP_3 719.58 4.18 8599 478255227 ENN75456.1 9075 0.0e+00 hypothetical protein YQE_08006, partial [Dendroctonus ponderosae] 759045107 XM_011333192.1 97 4.69365e-40 PREDICTED: Cerapachys biroi protein sidekick (LOC105275958), transcript variant X4, mRNA K16353 SDK protein sidekick http://www.genome.jp/dbget-bin/www_bget?ko:K16353 O97394 7400 0.0e+00 Protein sidekick OS=Drosophila melanogaster GN=sdk PE=1 SV=2 PF07646//PF00041//PF07354//PF13895//PF16656//PF02404 Kelch motif//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Stem cell factor GO:0007165//GO:0007339//GO:0019497//GO:0007155//GO:0006771 signal transduction//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//cell adhesion//riboflavin metabolic process GO:0005173//GO:0005515//GO:0003993//GO:0046872 stem cell factor receptor binding//protein binding//acid phosphatase activity//metal ion binding GO:0005576//GO:0016020 extracellular region//membrane KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.17366 BP_3 26.09 0.41 3377 641647038 XP_008181673.1 781 6.0e-80 PREDICTED: uncharacterized protein LOC103308999 [Acyrthosiphon pisum] 195457704 XM_002075642.1 88 1.8451e-35 Drosophila willistoni GK23549 (Dwil\GK23549), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17371 BP_3 8.00 0.60 935 270007709 EFA04157.1 926 2.6e-97 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 518 2.1e-51 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF01926//PF00664//PF03193//PF00005 50S ribosome-binding GTPase//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.17373 BP_3 69.01 1.59 2378 91087387 XP_975653.1 1433 1.1e-155 PREDICTED: glucosylceramidase-like [Tribolium castaneum] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 Q70KH2 942 3.7e-100 Glucosylceramidase OS=Sus scrofa GN=GBA PE=3 SV=1 PF02055 O-Glycosyl hydrolase family 30 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.1738 BP_3 63.00 2.77 1387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17381 BP_3 1.00 0.40 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17382 BP_3 816.00 88.73 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17383 BP_3 5.00 4.08 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17386 BP_3 162.18 4.45 2048 642920596 XP_008192479.1 1068 1.9e-113 PREDICTED: UPF0609 protein C4orf27 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CFE2 632 2.8e-64 UPF0609 protein C4orf27 homolog OS=Mus musculus PE=1 SV=1 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17387 BP_3 135.57 3.82 2002 642920596 XP_008192479.1 678 3.1e-68 PREDICTED: UPF0609 protein C4orf27 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CFE2 386 9.3e-36 UPF0609 protein C4orf27 homolog OS=Mus musculus PE=1 SV=1 PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17390 BP_3 13.09 1.04 898 642935120 XP_008197896.1 311 5.0e-26 PREDICTED: vigilin [Tribolium castaneum]>gi|270013832|gb|EFA10280.1| hypothetical protein TcasGA2_TC012484 [Tribolium castaneum] 642935119 XM_008199674.1 49 2.28513e-14 PREDICTED: Tribolium castaneum vigilin (LOC658150), mRNA -- -- -- -- Q8VDJ3 130 2.0e-06 Vigilin OS=Mus musculus GN=Hdlbp PE=1 SV=1 -- -- -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.17392 BP_3 12.09 0.36 1927 270010175 EFA06623.1 1135 3.1e-121 hypothetical protein TcasGA2_TC009541 [Tribolium castaneum] 687022647 LM525561.1 43 1.08284e-10 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_scaffold0000006 K10481 BTBD9 BTB/POZ domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10481 A4IFG2 852 8.2e-90 BTB/POZ domain-containing protein 9 OS=Bos taurus GN=BTBD9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4350 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.17394 BP_3 53.99 0.85 3351 478255117 ENN75347.1 919 5.9e-96 hypothetical protein YQE_08123, partial [Dendroctonus ponderosae] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 Q9UPI3 534 1.1e-52 Feline leukemia virus subgroup C receptor-related protein 2 OS=Homo sapiens GN=FLVCR2 PE=1 SV=1 PF10640//PF07690//PF03137 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006370//GO:0055085//GO:0006810 7-methylguanosine mRNA capping//transmembrane transport//transport GO:0004651//GO:0004484//GO:0005215 polynucleotide 5'-phosphatase activity//mRNA guanylyltransferase activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.17396 BP_3 165.99 3.31 2710 642937783 XP_008198943.1 1228 7.1e-132 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K14590 CMTR2, FTSJD1, AFT cap2 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14590 Q8IYT2 792 1.1e-82 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens GN=CMTR2 PE=1 SV=2 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.17399 BP_3 348.34 4.84 3762 642934627 XP_008197743.1 2424 2.0e-270 PREDICTED: atrial natriuretic peptide-converting enzyme isoform X2 [Tribolium castaneum] 752897157 XM_011268569.1 48 3.54213e-13 PREDICTED: Camponotus floridanus atrial natriuretic peptide-converting enzyme-like (LOC105257738), mRNA -- -- -- -- Q9Z319 394 2.1e-36 Atrial natriuretic peptide-converting enzyme OS=Mus musculus GN=Corin PE=2 SV=2 PF01392//PF10204//PF00057//PF00089 Fz domain//Dual oxidase maturation factor//Low-density lipoprotein receptor domain class A//Trypsin GO:0015031//GO:0006508 protein transport//proteolysis GO:0005515//GO:0004252 protein binding//serine-type endopeptidase activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.174 BP_3 19.98 1.12 1152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17400 BP_3 211.88 5.73 2075 642910915 XP_008193463.1 1475 1.2e-160 PREDICTED: LOW QUALITY PROTEIN: nischarin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2I1 675 3.0e-69 Nischarin OS=Homo sapiens GN=NISCH PE=1 SV=3 PF00787//PF13855 PX domain//Leucine rich repeat -- -- GO:0005515//GO:0035091 protein binding//phosphatidylinositol binding -- -- KOG1259 Nischarin, modulator of integrin alpha5 subunit action Cluster-8309.17401 BP_3 35.12 1.58 1364 642910915 XP_008193463.1 903 1.7e-94 PREDICTED: LOW QUALITY PROTEIN: nischarin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2I1 344 4.7e-31 Nischarin OS=Homo sapiens GN=NISCH PE=1 SV=3 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- -- -- Cluster-8309.17403 BP_3 117.00 3.28 2012 91086965 XP_973158.1 1286 9.9e-139 PREDICTED: protein NEDD1 [Tribolium castaneum]>gi|270009645|gb|EFA06093.1| hypothetical protein TcasGA2_TC008935 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NHV4 359 1.3e-32 Protein NEDD1 OS=Homo sapiens GN=NEDD1 PE=1 SV=1 PF04977//PF02911//PF00400 Septum formation initiator//Formyl transferase, C-terminal domain//WD domain, G-beta repeat GO:0007049//GO:0009058 cell cycle//biosynthetic process GO:0016742//GO:0005515 hydroxymethyl-, formyl- and related transferase activity//protein binding -- -- -- -- Cluster-8309.17408 BP_3 216.00 10.46 1287 91087191 XP_975444.1 968 4.7e-102 PREDICTED: SAGA-associated factor 29 homolog [Tribolium castaneum]>gi|270009566|gb|EFA06014.1| hypothetical protein TcasGA2_TC008842 [Tribolium castaneum] -- -- -- -- -- K11364 SGF29 SAGA-associated factor 29 http://www.genome.jp/dbget-bin/www_bget?ko:K11364 Q9DA08 648 2.5e-66 SAGA-associated factor 29 homolog OS=Mus musculus GN=Ccdc101 PE=2 SV=1 PF00631//PF08702//PF11744 GGL domain//Fibrinogen alpha/beta chain family//Aluminium activated malate transporter GO:0007186//GO:0030168//GO:0015743//GO:0051258//GO:0007165 G-protein coupled receptor signaling pathway//platelet activation//malate transport//protein polymerization//signal transduction GO:0030674//GO:0004871//GO:0005102 protein binding, bridging//signal transducer activity//receptor binding GO:0005577//GO:0005834 fibrinogen complex//heterotrimeric G-protein complex KOG3038 Histone acetyltransferase SAGA associated factor SGF29 Cluster-8309.17411 BP_3 42.06 0.62 3578 329350997 AEB91339.1 1457 2.6e-158 salicyl alcohol oxidase paralog 1 [Chrysomela lapponica] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 688 1.6e-70 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05834//PF07992//PF00732//PF01266//PF02254//PF05199 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//FAD dependent oxidoreductase//TrkA-N domain//GMC oxidoreductase GO:0016117//GO:0006813//GO:0055114 carotenoid biosynthetic process//potassium ion transport//oxidation-reduction process GO:0050660//GO:0016614//GO:0016705//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- -- -- Cluster-8309.17412 BP_3 12.00 0.78 1037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17414 BP_3 40.22 1.90 1312 642936637 XP_008198518.1 881 5.9e-92 PREDICTED: zinc finger and BTB domain-containing protein 12 [Tribolium castaneum] 642936636 XM_008200296.1 81 5.49225e-32 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 12 (LOC661906), mRNA -- -- -- -- Q01295 398 2.5e-37 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17416 BP_3 4.84 0.93 543 270003307 EEZ99754.1 502 2.2e-48 hypothetical protein TcasGA2_TC002523 [Tribolium castaneum] -- -- -- -- -- K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 251 1.1e-20 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.17418 BP_3 132.29 4.73 1640 642928077 XP_008200146.1 963 2.3e-101 PREDICTED: homer protein homolog 2 [Tribolium castaneum]>gi|270010897|gb|EFA07345.1| hypothetical protein TcasGA2_TC015941 [Tribolium castaneum] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 O88801 308 8.5e-27 Homer protein homolog 2 OS=Rattus norvegicus GN=Homer2 PE=1 SV=1 PF06703//PF16716//PF06810//PF04508//PF13851//PF04977//PF00038//PF07716//PF17078//PF15898//PF03938//PF10473//PF07989//PF04728//PF07926 Microsomal signal peptidase 25 kDa subunit (SPC25)//Bone marrow stromal antigen 2//Phage minor structural protein GP20//Viral A-type inclusion protein repeat//Growth-arrest specific micro-tubule binding//Septum formation initiator//Intermediate filament protein//Basic region leucine zipper//SWI5-dependent HO expression protein 3//cGMP-dependent protein kinase interacting domain//Outer membrane protein (OmpH-like)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Lipoprotein leucine-zipper//TPR/MLP1/MLP2-like protein GO:0006355//GO:0006606//GO:0007049//GO:0016032//GO:0051607//GO:0006465//GO:0051028//GO:0048309//GO:0048870 regulation of transcription, DNA-templated//protein import into nucleus//cell cycle//viral process//defense response to virus//signal peptide processing//mRNA transport//endoplasmic reticulum inheritance//cell motility GO:0043565//GO:0051082//GO:0019901//GO:0003700//GO:0008233//GO:0005198//GO:0045502//GO:0008134//GO:0042803 sequence-specific DNA binding//unfolded protein binding//protein kinase binding//transcription factor activity, sequence-specific DNA binding//peptidase activity//structural molecule activity//dynein binding//transcription factor binding//protein homodimerization activity GO:0005787//GO:0016021//GO:0005815//GO:0031514//GO:0005882//GO:0030286//GO:0019867//GO:0005667 signal peptidase complex//integral component of membrane//microtubule organizing center//motile cilium//intermediate filament//dynein complex//outer membrane//transcription factor complex -- -- Cluster-8309.17423 BP_3 28.54 0.84 1930 668447779 KFB37519.1 608 4.0e-60 AGAP011148-PA-like protein [Anopheles sinensis] 645021074 XM_008209220.1 57 1.78935e-18 PREDICTED: Nasonia vitripennis 39S ribosomal protein L14, mitochondrial (LOC100115115), transcript variant X3, mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 Q5ZJF4 416 3.0e-39 Peroxiredoxin-6 OS=Gallus gallus GN=PRDX6 PE=2 SV=3 PF08534//PF00578//PF00238 Redoxin//AhpC/TSA family//Ribosomal protein L14p/L23e GO:0006412//GO:0055114//GO:0042254 translation//oxidation-reduction process//ribosome biogenesis GO:0016491//GO:0016209//GO:0003735 oxidoreductase activity//antioxidant activity//structural constituent of ribosome GO:0005840 ribosome KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.17424 BP_3 33.09 1.01 1875 668447779 KFB37519.1 608 3.8e-60 AGAP011148-PA-like protein [Anopheles sinensis] 645021074 XM_008209220.1 57 1.73741e-18 PREDICTED: Nasonia vitripennis 39S ribosomal protein L14, mitochondrial (LOC100115115), transcript variant X3, mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 Q5ZJF4 416 2.9e-39 Peroxiredoxin-6 OS=Gallus gallus GN=PRDX6 PE=2 SV=3 PF00238//PF08534//PF00578 Ribosomal protein L14p/L23e//Redoxin//AhpC/TSA family GO:0006412//GO:0042254//GO:0055114 translation//ribosome biogenesis//oxidation-reduction process GO:0016491//GO:0016209//GO:0003735 oxidoreductase activity//antioxidant activity//structural constituent of ribosome GO:0005840 ribosome KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.17425 BP_3 163.00 12.37 927 642924778 XP_008194436.1 513 2.0e-49 PREDICTED: U6 snRNA-associated Sm-like protein LSm4 [Tribolium castaneum] 733924353 XM_010725105.1 90 3.81482e-37 PREDICTED: Meleagris gallopavo LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM4), mRNA K12623 LSM4 U6 snRNA-associated Sm-like protein LSm4 http://www.genome.jp/dbget-bin/www_bget?ko:K12623 Q9Y4Z0 471 6.0e-46 U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens GN=LSM4 PE=1 SV=1 PF10384 Centromere protein Scm3 -- -- GO:0042393 histone binding GO:0005634 nucleus KOG3293 Small nuclear ribonucleoprotein (snRNP) Cluster-8309.1743 BP_3 790.24 38.39 1284 642917922 XP_008200616.1 1047 3.3e-111 PREDICTED: probable cytochrome P450 303a1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q9V399 734 2.6e-76 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.17432 BP_3 65.00 5.18 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17434 BP_3 33.57 0.62 2918 642924981 XP_001811513.2 787 1.0e-80 PREDICTED: homeobox protein Mohawk [Tribolium castaneum] 462328280 APGK01040752.1 78 5.76511e-30 Dendroctonus ponderosae Seq01040762, whole genome shotgun sequence -- -- -- -- Q8IYA7 185 2.8e-12 Homeobox protein Mohawk OS=Homo sapiens GN=MKX PE=2 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.17437 BP_3 3.00 0.46 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17438 BP_3 3.00 0.57 545 189242016 XP_001807518.1 238 8.9e-18 PREDICTED: carboxypeptidase E-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04836 131 9.4e-07 Carboxypeptidase E OS=Bos taurus GN=CPE PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17441 BP_3 226.85 3.34 3565 642930179 XP_008196287.1 1897 2.5e-209 PREDICTED: protein dead ringer isoform X1 [Tribolium castaneum] 642930178 XM_008198065.1 438 0 PREDICTED: Tribolium castaneum protein dead ringer (LOC657345), transcript variant X1, mRNA -- -- -- -- Q24573 752 6.0e-78 Protein dead ringer OS=Drosophila melanogaster GN=retn PE=1 SV=2 PF01388 ARID/BRIGHT DNA binding domain -- -- GO:0003677 DNA binding -- -- KOG2744 DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain Cluster-8309.17444 BP_3 4.00 2.15 379 189238464 XP_966906.2 254 8.7e-20 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q29RZ2 157 6.3e-10 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Bos taurus GN=PPWD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17448 BP_3 1385.03 23.31 3156 270001047 EEZ97494.1 198 2.3e-12 hypothetical protein TcasGA2_TC011337 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83994 140 4.9e-07 Cuticle protein 18.6, isoform A OS=Locusta migratoria PE=1 SV=1 PF00379//PF04546 Insect cuticle protein//Sigma-70, non-essential region GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0042302//GO:0003700 DNA binding//sigma factor activity//structural constituent of cuticle//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.17451 BP_3 2.00 1.17 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17453 BP_3 155.00 10.22 1023 332376089 AEE63185.1 728 2.5e-74 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P4H8 538 1.1e-53 Protein FAM173B OS=Homo sapiens GN=FAM173B PE=1 SV=2 PF08123 Histone methylation protein DOT1 GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0018024 histone-lysine N-methyltransferase activity -- -- KOG4058 Uncharacterized conserved protein Cluster-8309.17455 BP_3 57.95 1.06 2922 642929686 XP_008195936.1 826 3.2e-85 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06064 HAIRLESS hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06064 Q02308 175 4.0e-11 Protein hairless OS=Drosophila melanogaster GN=H PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17456 BP_3 26.99 1.18 1394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17457 BP_3 19.00 1.09 1133 410509310 BAM65721.1 1365 3.9e-148 myosin heavy chain type 1 [Litopenaeus vannamei] -- -- -- -- -- K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 1218 1.8e-132 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF06810//PF01920//PF13851//PF06009//PF12317//PF00038//PF07926//PF09728//PF01576//PF04111//PF06156//PF00769//PF15898//PF09177//PF10473//PF00015//PF04136 Phage minor structural protein GP20//Prefoldin subunit//Growth-arrest specific micro-tubule binding//Laminin Domain II//Intraflagellar transport complex B protein 46 C terminal//Intermediate filament protein//TPR/MLP1/MLP2-like protein//Myosin-like coiled-coil protein//Myosin tail//Autophagy protein Apg6//Protein of unknown function (DUF972)//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//Syntaxin 6, N-terminal//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family GO:0006914//GO:0006886//GO:0007165//GO:0042073//GO:0006606//GO:0006260//GO:0048870//GO:0048193//GO:0006457//GO:0007155 autophagy//intracellular protein transport//signal transduction//intraciliary transport//protein import into nucleus//DNA replication//cell motility//Golgi vesicle transport//protein folding//cell adhesion GO:0005198//GO:0008134//GO:0045502//GO:0051082//GO:0019901//GO:0019905//GO:0008092//GO:0042803//GO:0003774//GO:0004871 structural molecule activity//transcription factor binding//dynein binding//unfolded protein binding//protein kinase binding//syntaxin binding//cytoskeletal protein binding//protein homodimerization activity//motor activity//signal transducer activity GO:0005882//GO:0019898//GO:0016459//GO:0031514//GO:0005737//GO:0016272//GO:0005801//GO:0005667//GO:0030286//GO:0016020 intermediate filament//extrinsic component of membrane//myosin complex//motile cilium//cytoplasm//prefoldin complex//cis-Golgi network//transcription factor complex//dynein complex//membrane -- -- Cluster-8309.17459 BP_3 38.09 2.32 1082 478257312 ENN77472.1 207 7.0e-14 hypothetical protein YQE_06000, partial [Dendroctonus ponderosae]>gi|546679541|gb|ERL89989.1| hypothetical protein D910_07348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17460 BP_3 91.00 9.55 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17462 BP_3 362.39 5.10 3715 478249944 ENN70451.1 1866 1.0e-205 hypothetical protein YQE_12955, partial [Dendroctonus ponderosae] 642934506 XM_008199471.1 152 5.37613e-71 PREDICTED: Tribolium castaneum calcium homeostasis endoplasmic reticulum protein (LOC100142080), transcript variant X3, mRNA K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8IWX8 487 3.4e-47 Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens GN=CHERP PE=1 SV=3 PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.17464 BP_3 216.07 18.17 865 91085791 XP_976450.1 551 7.2e-54 PREDICTED: uncharacterized protein LOC663387 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D0V8 158 1.1e-09 Cyclin-dependent kinase 2-interacting protein OS=Mus musculus GN=Cinp PE=2 SV=1 PF03232 Ubiquinone biosynthesis protein COQ7 GO:0006744//GO:0055114 ubiquinone biosynthetic process//oxidation-reduction process -- -- -- -- -- -- Cluster-8309.17465 BP_3 2.00 0.31 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17467 BP_3 17.00 0.99 1118 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17468 BP_3 47.86 2.36 1269 642918004 XP_008198977.1 683 5.2e-69 PREDICTED: N-alpha-acetyltransferase 60 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX8 442 1.9e-42 N-alpha-acetyltransferase 60 OS=Drosophila melanogaster GN=Naa60 PE=1 SV=1 PF13302//PF13673//PF08445//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3138 Predicted N-acetyltransferase Cluster-8309.1747 BP_3 61.00 3.72 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17473 BP_3 38.13 1.87 1274 478260276 ENN80028.1 271 3.1e-21 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2EI20 183 2.0e-12 RE1-silencing transcription factor OS=Danio rerio GN=rest PE=2 SV=1 PF07649//PF13465//PF00096//PF03348//PF06309 C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type//Serine incorporator (Serinc)//Torsin GO:0055114 oxidation-reduction process GO:0005524//GO:0046872//GO:0047134 ATP binding//metal ion binding//protein-disulfide reductase activity GO:0016020 membrane KOG1721 FOG: Zn-finger Cluster-8309.17474 BP_3 38.55 1.67 1407 546684929 ERL94511.1 162 1.5e-08 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.17475 BP_3 51.97 0.71 3828 642935735 XP_008198150.1 1598 1.3e-174 PREDICTED: RNA polymerase II-associated protein 1 [Tribolium castaneum]>gi|270013972|gb|EFA10420.1| hypothetical protein TcasGA2_TC012660 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JN53 482 1.3e-46 RNA polymerase II-associated protein 1 OS=Bos taurus GN=RPAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4732 Uncharacterized conserved protein Cluster-8309.17479 BP_3 105.02 2.18 2617 642912496 XP_008200890.1 1793 2.1e-197 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LUQ4 218 3.7e-16 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17486 BP_3 17.15 2.01 703 91085175 XP_971032.1 767 5.3e-79 PREDICTED: ubiquitin-conjugating enzyme E2 G1 [Tribolium castaneum]>gi|270008468|gb|EFA04916.1| hypothetical protein TcasGA2_TC014980 [Tribolium castaneum] 642926418 XM_965939.2 268 3.20918e-136 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2 G1 (LOC659653), mRNA K10575 UBE2G1, UBC7 ubiquitin-conjugating enzyme E2 G1 http://www.genome.jp/dbget-bin/www_bget?ko:K10575 P62253 690 1.8e-71 Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens GN=UBE2G1 PE=1 SV=3 PF05773 RWD domain -- -- GO:0005515//GO:0005524//GO:0016881 protein binding//ATP binding//acid-amino acid ligase activity -- -- KOG0425 Ubiquitin-protein ligase Cluster-8309.17487 BP_3 112.73 7.22 1044 91079358 XP_970171.1 573 2.4e-56 PREDICTED: ankyrin repeat domain-containing protein 54 [Tribolium castaneum]>gi|270003493|gb|EEZ99940.1| hypothetical protein TcasGA2_TC002736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NXT1 323 9.8e-29 Ankyrin repeat domain-containing protein 54 OS=Homo sapiens GN=ANKRD54 PE=1 SV=2 PF00023//PF13606//PF00831 Ankyrin repeat//Ankyrin repeat//Ribosomal L29 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.17490 BP_3 110.26 2.27 2637 91077430 XP_966364.1 2481 3.5e-277 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [Tribolium castaneum]>gi|270001627|gb|EEZ98074.1| hypothetical protein TcasGA2_TC000481 [Tribolium castaneum] 752892703 XM_011266149.1 450 0 PREDICTED: Camponotus floridanus putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 (LOC105256330), mRNA K12820 DHX15, PRP43 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12820 Q5RAZ4 2035 7.5e-227 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Pongo abelii GN=DHX15 PE=2 SV=2 PF00005//PF04851//PF09339//PF00270//PF07652//PF01695//PF00063//PF04408//PF00437//PF00448 ABC transporter//Type III restriction enzyme, res subunit//IclR helix-turn-helix domain//DEAD/DEAH box helicase//Flavivirus DEAD domain//IstB-like ATP binding protein//Myosin head (motor domain)//Helicase associated domain (HA2)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain GO:0006810//GO:0006614//GO:0019079//GO:0006355 transport//SRP-dependent cotranslational protein targeting to membrane//viral genome replication//regulation of transcription, DNA-templated GO:0008026//GO:0003677//GO:0016787//GO:0005524//GO:0004386//GO:0003676//GO:0016887//GO:0003774//GO:0005525 ATP-dependent helicase activity//DNA binding//hydrolase activity//ATP binding//helicase activity//nucleic acid binding//ATPase activity//motor activity//GTP binding GO:0016459 myosin complex KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.17494 BP_3 83.60 0.93 4638 546683622 ERL93410.1 808 6.1e-83 hypothetical protein D910_10702 [Dendroctonus ponderosae] 676494731 XM_009068407.1 36 2.04989e-06 Lottia gigantea hypothetical protein mRNA K01057 PGLS, pgl, devB 6-phosphogluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01057 P85971 457 1.3e-43 6-phosphogluconolactonase OS=Rattus norvegicus GN=Pgls PE=1 SV=1 PF04851//PF01182//PF09771 Type III restriction enzyme, res subunit//Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase//Transmembrane protein 188 GO:0005975//GO:0035307 carbohydrate metabolic process//positive regulation of protein dephosphorylation GO:0005524//GO:0016787//GO:0003677 ATP binding//hydrolase activity//DNA binding GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.17497 BP_3 4.00 1.53 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17499 BP_3 3.00 0.31 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.175 BP_3 20.00 1.34 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17500 BP_3 56.15 4.25 929 270000856 EEZ97303.1 236 2.6e-17 hypothetical protein TcasGA2_TC011112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17501 BP_3 411.36 4.40 4793 642932410 XP_008197100.1 2293 4.0e-255 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AK53 362 1.4e-32 Espin OS=Homo sapiens GN=ESPN PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17502 BP_3 9.48 1.19 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17506 BP_3 1001.74 7.68 6579 795370015 XP_011748985.1 261 2.3e-19 PREDICTED: neurofilament heavy polypeptide isoform X4 [Macaca nemestrina]>gi|795370020|ref|XP_011748986.1| PREDICTED: neurofilament heavy polypeptide isoform X5 [Macaca nemestrina]>gi|795370026|ref|XP_011748987.1| PREDICTED: neurofilament heavy polypeptide isoform X6 [Macaca nemestrina] -- -- -- -- -- -- -- -- -- P12036 226 1.1e-16 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.17507 BP_3 4.00 0.90 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17514 BP_3 43.87 0.98 2444 642916262 XP_008190953.1 1208 1.3e-129 PREDICTED: thyrotropin-releasing hormone receptor isoform X3 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.6e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.17518 BP_3 96.29 3.97 1460 823414644 XP_012414975.1 292 1.3e-23 PREDICTED: zinc finger protein 883-like [Trichechus manatus latirostris] -- -- -- -- -- K09233 GLIS2 zinc finger protein GLIS2 http://www.genome.jp/dbget-bin/www_bget?ko:K09233 Q7K0S9 626 1.0e-63 Zinc finger protein GLIS2 homolog OS=Drosophila melanogaster GN=sug PE=2 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.17522 BP_3 9.00 0.36 1498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17525 BP_3 29.74 0.75 2194 478264299 ENN82205.1 1261 8.6e-136 hypothetical protein YQE_01419, partial [Dendroctonus ponderosae]>gi|478270474|gb|ENN83516.1| hypothetical protein YQE_00127, partial [Dendroctonus ponderosae] 642937798 XM_008202083.1 221 1.38752e-109 PREDICTED: Tribolium castaneum cleavage stimulation factor subunit 2 tau variant (LOC659353), mRNA K14407 CSTF2, RNA15 cleavage stimulation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14407 Q8BIQ5 711 2.1e-73 Cleavage stimulation factor subunit 2 OS=Mus musculus GN=Cstf2 PE=1 SV=2 PF14304//PF16367//PF00076 Transcription termination and cleavage factor C-terminal//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0031124 mRNA 3'-end processing GO:0003676 nucleic acid binding -- -- KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15 Cluster-8309.17528 BP_3 5.19 0.34 1023 270012485 EFA08933.1 481 1.1e-45 hypothetical protein TcasGA2_TC006640 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04690 YABBY protein GO:0007275 multicellular organismal development -- -- -- -- -- -- Cluster-8309.17529 BP_3 46.82 0.90 2794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03798//PF15510//PF01098//PF03470 TLC domain//Centromere kinetochore component W//Cell cycle protein//XS zinc finger domain GO:0051382//GO:0007067//GO:0031047//GO:0051301 kinetochore assembly//mitotic nuclear division//gene silencing by RNA//cell division GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.17530 BP_3 94.00 4.33 1338 572310259 XP_006620896.1 208 6.6e-14 PREDICTED: chaoptin-like isoform X1 [Apis dorsata] -- -- -- -- -- -- -- -- -- Q6P1C6 162 5.9e-10 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Mus musculus GN=Lrig3 PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17533 BP_3 2.00 0.41 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17537 BP_3 186.87 1.03 9033 642917872 XP_969181.2 2653 1.4e-296 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F3V0 345 2.4e-30 SET and MYND domain-containing protein 4 OS=Gallus gallus GN=SMYD4 PE=2 SV=1 PF13414//PF01233//PF00856//PF13181 TPR repeat//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//SET domain//Tetratricopeptide repeat GO:0042967 acyl-carrier-protein biosynthetic process GO:0005515//GO:0004379//GO:0008270 protein binding//glycylpeptide N-tetradecanoyltransferase activity//zinc ion binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.17539 BP_3 76.94 0.42 9077 642917872 XP_969181.2 2653 1.4e-296 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F3V0 345 2.4e-30 SET and MYND domain-containing protein 4 OS=Gallus gallus GN=SMYD4 PE=2 SV=1 PF13181//PF01233//PF00856//PF13414 Tetratricopeptide repeat//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//SET domain//TPR repeat GO:0042967 acyl-carrier-protein biosynthetic process GO:0008270//GO:0005515//GO:0004379 zinc ion binding//protein binding//glycylpeptide N-tetradecanoyltransferase activity -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.1754 BP_3 75.10 3.77 1251 642939700 XP_008201385.1 247 1.9e-18 PREDICTED: uncharacterized protein LOC103315171 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17051//PF01352 Cytochrome C oxidase assembly factor 2//KRAB box GO:0033617//GO:0006355 mitochondrial respiratory chain complex IV assembly//regulation of transcription, DNA-templated GO:0003676 nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.17540 BP_3 198.02 1.11 8908 642917872 XP_969181.2 2653 1.3e-296 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F3V0 345 2.4e-30 SET and MYND domain-containing protein 4 OS=Gallus gallus GN=SMYD4 PE=2 SV=1 PF13414//PF01233//PF00856//PF13181 TPR repeat//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//SET domain//Tetratricopeptide repeat GO:0042967 acyl-carrier-protein biosynthetic process GO:0008270//GO:0004379//GO:0005515 zinc ion binding//glycylpeptide N-tetradecanoyltransferase activity//protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.17541 BP_3 1.00 5.73 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17545 BP_3 9.00 1.10 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17547 BP_3 215.00 11.99 1156 546680922 ERL91096.1 898 5.6e-94 hypothetical protein D910_08438 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBS1 331 1.3e-29 Metaxin-1 OS=Bos taurus GN=MTX1 PE=2 SV=1 PF10568 Outer mitochondrial membrane transport complex protein GO:0006626 protein targeting to mitochondrion -- -- GO:0005741 mitochondrial outer membrane KOG3028 Translocase of outer mitochondrial membrane complex, subunit TOM37/Metaxin 1 Cluster-8309.17548 BP_3 13.70 0.41 1888 328701369 XP_003241578.1 565 3.7e-55 PREDICTED: KRAB-A domain-containing protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6R2W3 495 2.0e-48 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 PF06184//PF00665 Potexvirus coat protein//Integrase core domain GO:0015074 DNA integration GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.17549 BP_3 53.65 1.15 2534 478251577 ENN72039.1 659 6.3e-66 hypothetical protein YQE_11327, partial [Dendroctonus ponderosae] -- -- -- -- -- K00798 MMAB, pduO cob(I)alamin adenosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00798 Q96EY8 328 6.3e-29 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial OS=Homo sapiens GN=MMAB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1755 BP_3 2.00 0.70 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17550 BP_3 35.50 1.48 1447 642911863 XP_008200779.1 668 3.3e-67 PREDICTED: uncharacterized protein LOC660579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17551 BP_3 8.00 0.40 1264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17553 BP_3 62.78 5.07 888 270016876 EFA13322.1 591 1.7e-58 hypothetical protein TcasGA2_TC006845 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17556 BP_3 79.63 1.30 3235 385199932 AFI45014.1 1346 1.8e-145 cytochrome P450 CYP411a1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P29981 654 1.3e-66 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.17562 BP_3 19.75 0.32 3234 91085955 XP_971224.1 2403 4.8e-268 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q80V86 398 6.1e-37 Integrator complex subunit 8 OS=Mus musculus GN=Ints8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17564 BP_3 27.36 0.46 3182 546672915 ERL84631.1 561 1.8e-54 hypothetical protein D910_02059 [Dendroctonus ponderosae] -- -- -- -- -- K03842 ALG1 beta-1,4-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03842 Q921Q3 351 1.7e-31 Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Mus musculus GN=Alg1 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2941 Beta-1,4-mannosyltransferase Cluster-8309.17566 BP_3 10.00 0.66 1024 600833 AAC46945.1 794 5.7e-82 mariner transposase [Chrysoperla plorabunda] 689914875 LM395878.1 76 2.56339e-29 Hymenolepis diminuta genome assembly H_diminuta_Denmark ,scaffold HDID_contig0009570 -- -- -- -- Q53H47 251 2.1e-20 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF04509 CheC-like family -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.1757 BP_3 38.00 0.53 3719 857970880 CEP02741.1 1559 4.0e-170 hypothetical protein PBRA_002708 [Plasmodiophora brassicae] 697080660 XM_009655603.1 3354 0 Verticillium dahliae VdLs.17 calcium-transporting ATPase partial mRNA -- -- -- -- P22189 2235 6.8e-250 Calcium-transporting ATPase 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cta3 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.17571 BP_3 238.53 2.22 5480 270003811 EFA00259.1 2983 0.0e+00 hypothetical protein TcasGA2_TC003092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.4e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.17573 BP_3 32.49 0.33 5040 642926255 XP_008194846.1 2748 7.4e-308 PREDICTED: kelch-like protein 17 [Tribolium castaneum]>gi|270008515|gb|EFA04963.1| hypothetical protein TcasGA2_TC015037 [Tribolium castaneum] 195029940 XM_001987794.1 64 6.0672e-22 Drosophila grimshawi GH19736 (Dgri\GH19736), mRNA K10454 KLHL17 kelch-like protein 17 (actinfilin) http://www.genome.jp/dbget-bin/www_bget?ko:K10454 Q6TDP3 1717 1.1e-189 Kelch-like protein 17 OS=Mus musculus GN=Klhl17 PE=2 SV=1 PF00651//PF04185//PF07646//PF00884//PF01344 BTB/POZ domain//Phosphoesterase family//Kelch motif//Sulfatase//Kelch motif GO:0008152 metabolic process GO:0016788//GO:0008484//GO:0005515 hydrolase activity, acting on ester bonds//sulfuric ester hydrolase activity//protein binding -- -- -- -- Cluster-8309.17575 BP_3 2.00 0.36 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17576 BP_3 4.90 0.47 798 270010347 EFA06795.1 156 4.2e-08 hypothetical protein TcasGA2_TC009733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17577 BP_3 4.03 0.76 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1758 BP_3 1.00 22.75 223 -- -- -- -- -- 768311755 CP010983.1 214 9.56552e-107 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17582 BP_3 1117.96 104.98 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17584 BP_3 49.38 1.38 2020 91094273 XP_970483.1 609 3.2e-60 PREDICTED: ethylmalonyl-CoA decarboxylase [Tribolium castaneum]>gi|270014393|gb|EFA10841.1| hypothetical protein TcasGA2_TC001618 [Tribolium castaneum] -- -- -- -- -- K18426 ECHDC1 ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K18426 F1NB38 391 2.5e-36 Ethylmalonyl-CoA decarboxylase OS=Gallus gallus GN=ECHDC1 PE=3 SV=2 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0003824//GO:0016836 catalytic activity//hydro-lyase activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.17585 BP_3 17.00 0.34 2719 795019327 XP_011859539.1 511 9.9e-49 PREDICTED: jerky protein homolog-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- P04323 252 4.4e-20 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00501//PF03184 AMP-binding enzyme//DDE superfamily endonuclease GO:0008152 metabolic process GO:0003676//GO:0003824 nucleic acid binding//catalytic activity -- -- -- -- Cluster-8309.17586 BP_3 2.00 7.40 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17591 BP_3 31.76 0.40 4137 91079786 XP_967971.1 1583 7.4e-173 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 9.0e-126 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607 Chitin binding Peritrophin-A domain GO:0006396//GO:0042254//GO:0006030 RNA processing//ribosome biogenesis//chitin metabolic process GO:0008061//GO:0003824 chitin binding//catalytic activity GO:0005730//GO:0005576 nucleolus//extracellular region KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.17594 BP_3 32.19 0.53 3221 391335701 XP_003742228.1 618 4.6e-61 PREDICTED: uncharacterized protein LOC100899883 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17599 BP_3 25.98 0.37 3719 332376021 AEE63151.1 2102 4.4e-233 unknown [Dendroctonus ponderosae]>gi|478258545|gb|ENN78616.1| hypothetical protein YQE_04920, partial [Dendroctonus ponderosae] 826416467 XM_012667541.1 171 1.47537e-81 PREDICTED: Monomorium pharaonis asparagine--tRNA ligase, cytoplasmic (LOC105828947), mRNA K01893 NARS, asnS asparaginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01893 Q2KJG3 1755 3.1e-194 Asparagine--tRNA ligase, cytoplasmic OS=Bos taurus GN=NARS PE=2 SV=3 PF01336//PF00237//PF00152 OB-fold nucleic acid binding domain//Ribosomal protein L22p/L17e//tRNA synthetases class II (D, K and N) GO:0042254//GO:0006418//GO:0006412 ribosome biogenesis//tRNA aminoacylation for protein translation//translation GO:0004812//GO:0003676//GO:0003735//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleic acid binding//structural constituent of ribosome//nucleotide binding//ATP binding GO:0005840 ribosome KOG0555 Asparaginyl-tRNA synthetase Cluster-8309.17600 BP_3 23.48 0.58 2254 2660868 AAC48288.1 1090 5.9e-116 fast tropomyosin isoform [Homarus americanus] 125995168 AB270635.1 946 0 Erimacrus isenbeckii Tm-Erii-twitch mRNA for tropomyosin slow-twitch isoform, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 O44119 1134 1.9e-122 Tropomyosin OS=Homarus americanus GN=TM1 PE=1 SV=1 PF04706//PF04111//PF16716//PF06160//PF10473//PF05739//PF05557//PF00769//PF06009//PF00435//PF06008//PF14073//PF06109//PF07926//PF02601//PF08702 Dickkopf N-terminal cysteine-rich region//Autophagy protein Apg6//Bone marrow stromal antigen 2//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Mitotic checkpoint protein//Ezrin/radixin/moesin family//Laminin Domain II//Spectrin repeat//Laminin Domain I//Centrosome localisation domain of Cep57//Haemolysin E (HlyE)//TPR/MLP1/MLP2-like protein//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family GO:0051258//GO:0006914//GO:0007165//GO:0009405//GO:0044179//GO:0030334//GO:0051607//GO:0006308//GO:0030178//GO:0007094//GO:0007155//GO:0030155//GO:0045995//GO:0006606//GO:0000921//GO:0007275//GO:0030168 protein polymerization//autophagy//signal transduction//pathogenesis//hemolysis in other organism//regulation of cell migration//defense response to virus//DNA catabolic process//negative regulation of Wnt signaling pathway//mitotic spindle assembly checkpoint//cell adhesion//regulation of cell adhesion//regulation of embryonic development//protein import into nucleus//septin ring assembly//multicellular organismal development//platelet activation GO:0005515//GO:0008855//GO:0042802//GO:0043015//GO:0042803//GO:0008134//GO:0045502//GO:0005102//GO:0008092//GO:0030674 protein binding//exodeoxyribonuclease VII activity//identical protein binding//gamma-tubulin binding//protein homodimerization activity//transcription factor binding//dynein binding//receptor binding//cytoskeletal protein binding//protein binding, bridging GO:0005940//GO:0016021//GO:0005737//GO:0005576//GO:0045298//GO:0019898//GO:0005577//GO:0009318//GO:0005667//GO:0030286 septin ring//integral component of membrane//cytoplasm//extracellular region//tubulin complex//extrinsic component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//transcription factor complex//dynein complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.1761 BP_3 2.00 0.37 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17610 BP_3 6.00 0.43 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17612 BP_3 3.00 0.38 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17613 BP_3 42.52 0.72 3144 642935498 XP_008198034.1 4652 0.0e+00 PREDICTED: rap guanine nucleotide exchange factor 4 isoform X1 [Tribolium castaneum] 676496084 XM_009068851.1 107 4.70526e-46 Lottia gigantea hypothetical protein partial mRNA K04351 RAPGEF4, EPAC2 Rap guanine nucleotide exchange factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04351 Q8WZA2 2519 6.8e-283 Rap guanine nucleotide exchange factor 4 OS=Homo sapiens GN=RAPGEF4 PE=1 SV=1 PF00617//PF00610 RasGEF domain//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556//GO:0007264//GO:0043087 intracellular signal transduction//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG2378 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.17617 BP_3 4.08 0.36 836 307179891 EFN68048.1 136 9.2e-06 Gastrula zinc finger protein xFG20-1 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.17618 BP_3 14.00 1.43 765 189235395 XP_001810980.1 290 1.2e-23 PREDICTED: uncharacterized protein LOC100142132 [Tribolium castaneum]>gi|270003582|gb|EFA00030.1| hypothetical protein TcasGA2_TC002837 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17619 BP_3 16.53 0.38 2384 91090196 XP_967193.1 1568 2.3e-171 PREDICTED: cyclin-G-associated kinase [Tribolium castaneum]>gi|270013468|gb|EFA09916.1| hypothetical protein TcasGA2_TC012067 [Tribolium castaneum] -- -- -- -- -- K08855 GAK cyclin G-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08855 P97874 392 2.2e-36 Cyclin-G-associated kinase OS=Rattus norvegicus GN=Gak PE=2 SV=1 -- -- -- -- GO:0005488//GO:0016301 binding//kinase activity -- -- KOG0431 Auxilin-like protein and related proteins containing DnaJ domain Cluster-8309.17622 BP_3 12.00 0.70 1117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17624 BP_3 349.42 4.46 4066 642915469 XP_008190632.1 1964 4.8e-217 PREDICTED: TBC1 domain family member 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2M4 995 4.6e-106 TBC1 domain family member 14 OS=Homo sapiens GN=TBC1D14 PE=1 SV=3 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG2223 Uncharacterized conserved protein, contains TBC domain Cluster-8309.17626 BP_3 168.37 2.17 4034 642915469 XP_008190632.1 1964 4.8e-217 PREDICTED: TBC1 domain family member 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2M4 995 4.5e-106 TBC1 domain family member 14 OS=Homo sapiens GN=TBC1D14 PE=1 SV=3 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2223 Uncharacterized conserved protein, contains TBC domain Cluster-8309.17627 BP_3 116.58 1.38 4376 642915469 XP_008190632.1 1738 8.3e-191 PREDICTED: TBC1 domain family member 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2M4 877 2.4e-92 TBC1 domain family member 14 OS=Homo sapiens GN=TBC1D14 PE=1 SV=3 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG2223 Uncharacterized conserved protein, contains TBC domain Cluster-8309.1763 BP_3 34.24 0.98 1977 546678293 ERL88946.1 193 5.4e-12 hypothetical protein D910_06324 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17634 BP_3 9.00 0.47 1213 642920389 XP_008192326.1 233 7.6e-17 PREDICTED: probable H/ACA ribonucleoprotein complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17636 BP_3 52.67 0.59 4585 270005292 EFA01740.1 2207 3.6e-245 hypothetical protein TcasGA2_TC007336 [Tribolium castaneum] 817199620 XM_012420083.1 130 1.12821e-58 PREDICTED: Orussus abietinus uncharacterized LOC105697085 (LOC105697085), transcript variant X3, mRNA -- -- -- -- Q6P116 879 1.5e-92 REST corepressor 2 OS=Danio rerio GN=rcor2 PE=2 SV=1 PF04977//PF00320//PF00376 Septum formation initiator//GATA zinc finger//MerR family regulatory protein GO:0007049//GO:0006355 cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG1194 Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains Cluster-8309.17638 BP_3 34.00 1.91 1148 752890929 XP_011263479.1 245 2.9e-18 PREDICTED: probable serine/threonine-protein kinase DDB_G0277165 [Camponotus floridanus]>gi|752890931|ref|XP_011263480.1| PREDICTED: probable serine/threonine-protein kinase DDB_G0277165 [Camponotus floridanus]>gi|307171702|gb|EFN63437.1| SNF-related serine/threonine-protein kinase [Camponotus floridanus] 828210619 XM_004208630.2 51 2.27766e-15 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 237 1.0e-18 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF00069 Protein kinase domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0583 Serine/threonine protein kinase Cluster-8309.17639 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17640 BP_3 29.00 0.81 2007 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17643 BP_3 17.81 0.43 2283 642921234 XP_008192774.1 1587 1.4e-173 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X3 [Tribolium castaneum] 642921233 XM_008194552.1 277 1.07042e-140 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X6, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q62415 386 1.1e-35 Apoptosis-stimulating of p53 protein 1 OS=Mus musculus GN=Ppp1r13b PE=2 SV=2 PF05188 MutS domain II GO:0006298 mismatch repair GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- -- -- Cluster-8309.17645 BP_3 4.00 3.98 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17647 BP_3 31.88 2.06 1038 270001010 EEZ97457.1 1273 1.6e-137 hypothetical protein TcasGA2_TC011288 [Tribolium castaneum] 551486143 XM_005794597.1 64 1.21808e-22 PREDICTED: Xiphophorus maculatus calcium-activated potassium channel subunit alpha-1-like (LOC102225404), transcript variant X3, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1158 1.5e-125 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.17648 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17649 BP_3 60.00 1.61 2087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1765 BP_3 5.00 0.92 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17652 BP_3 6.52 0.33 1250 861605580 KMQ84383.1 273 1.8e-21 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17656 BP_3 2.00 0.32 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17657 BP_3 19.81 0.52 2137 546673768 ERL85319.1 1280 5.2e-138 hypothetical protein D910_02739 [Dendroctonus ponderosae] 462282558 APGK01057257.1 55 2.56751e-17 Dendroctonus ponderosae Seq01057267, whole genome shotgun sequence -- -- -- -- Q9D9I4 693 2.5e-71 TBC1 domain family member 20 OS=Mus musculus GN=Tbc1d20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2595 Predicted GTPase activator protein Cluster-8309.1766 BP_3 47.39 0.72 3454 642917922 XP_008200616.1 1570 2.0e-171 PREDICTED: probable cytochrome P450 303a1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q9V399 1053 7.3e-113 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.17660 BP_3 436.03 6.16 3701 642933135 XP_973578.2 3493 0.0e+00 PREDICTED: DNA topoisomerase 3-alpha [Tribolium castaneum] 571572814 XM_394050.5 155 1.15113e-72 PREDICTED: Apis mellifera DNA topoisomerase 3-alpha-like (LOC410571), mRNA K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 Q9NG98 2222 2.2e-248 DNA topoisomerase 3-alpha OS=Drosophila melanogaster GN=Top3alpha PE=2 SV=2 PF16588//PF06839//PF01396//PF00098//PF01022//PF00556//PF01131 C2H2 zinc-finger//GRF zinc finger//Topoisomerase DNA binding C4 zinc finger//Zinc knuckle//Bacterial regulatory protein, arsR family//Antenna complex alpha/beta subunit//DNA topoisomerase GO:0006118//GO:0006355//GO:0019684//GO:0006265 obsolete electron transport//regulation of transcription, DNA-templated//photosynthesis, light reaction//DNA topological change GO:0008270//GO:0003676//GO:0003700//GO:0003677//GO:0003916//GO:0045156 zinc ion binding//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//DNA binding//DNA topoisomerase activity//electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GO:0005694//GO:0016021//GO:0005667//GO:0030077 chromosome//integral component of membrane//transcription factor complex//plasma membrane light-harvesting complex KOG1956 DNA topoisomerase III alpha Cluster-8309.17665 BP_3 7.12 0.33 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01191 RNA polymerase Rpb5, C-terminal domain GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.17666 BP_3 402.62 15.92 1511 91083575 XP_968060.1 1166 6.1e-125 PREDICTED: ribonuclease H2 subunit B [Tribolium castaneum]>gi|270007823|gb|EFA04271.1| hypothetical protein TcasGA2_TC014561 [Tribolium castaneum] -- -- -- -- -- K10744 RNASEH2B ribonuclease H2 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10744 Q28GD9 376 1.0e-34 Ribonuclease H2 subunit B OS=Xenopus tropicalis GN=rnaseh2b PE=2 SV=1 PF09468 Ydr279p protein family (RNase H2 complex component) -- -- -- -- GO:0005634 nucleus KOG4705 Uncharacterized conserved protein Cluster-8309.17667 BP_3 610.14 43.10 974 31235339 XP_319221.1 1051 8.5e-112 AGAP010064-PA [Anopheles gambiae str. PEST]>gi|157128329|ref|XP_001661404.1| AAEL011087-PA [Aedes aegypti]>gi|170059825|ref|XP_001865530.1| DNA-directed RNA polymerase II 23 kDa polypeptide [Culex quinquefasciatus]>gi|30174740|gb|EAA43596.1| AGAP010064-PA [Anopheles gambiae str. PEST]>gi|108872649|gb|EAT36874.1| AAEL011087-PA [Aedes aegypti]>gi|167878475|gb|EDS41858.1| DNA-directed RNA polymerase II 23 kDa polypeptide [Culex quinquefasciatus]>gi|668456857|gb|KFB44941.1| AGAP010064-PA-like protein [Anopheles sinensis] 805824078 XM_003708039.2 240 1.65657e-120 PREDICTED: Megachile rotundata DNA-directed RNA polymerases I, II, and III subunit RPABC1 (LOC100882861), mRNA K03013 RPB5, POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03013 Q5R587 939 3.4e-100 DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Pongo abelii GN=POLR2E PE=2 SV=1 PF03871//PF01191 RNA polymerase Rpb5, N-terminal domain//RNA polymerase Rpb5, C-terminal domain GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus KOG3218 RNA polymerase, 25-kDa subunit (common to polymerases I, II and III) Cluster-8309.17672 BP_3 47.00 2.56 1178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17673 BP_3 22.34 3.33 615 270013391 EFA09839.1 971 1.0e-102 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AVA0 146 1.9e-08 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus GN=Svep1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17677 BP_3 44.08 0.86 2749 91076500 XP_973094.1 2588 1.4e-289 PREDICTED: alkaline phosphatase-like [Tribolium castaneum] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 Q92058 1041 1.4e-111 Alkaline phosphatase, tissue-nonspecific isozyme OS=Gallus gallus GN=ALPL PE=2 SV=1 PF00549//PF00245//PF08170//PF01676 CoA-ligase//Alkaline phosphatase//POPLD (NUC188) domain//Metalloenzyme superfamily GO:0006396//GO:0051252//GO:0008033//GO:0008152 RNA processing//regulation of RNA metabolic process//tRNA processing//metabolic process GO:0046872//GO:0004526//GO:0016791//GO:0003824 metal ion binding//ribonuclease P activity//phosphatase activity//catalytic activity GO:0030677 ribonuclease P complex -- -- Cluster-8309.17678 BP_3 12.13 0.84 984 270002027 EEZ98474.1 286 4.4e-23 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02176 TRAF-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.1768 BP_3 9.00 3.39 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17680 BP_3 9.86 0.32 1795 195446244 XP_002070694.1 969 5.1e-102 GK10887 [Drosophila willistoni]>gi|194166779|gb|EDW81680.1| GK10887 [Drosophila willistoni] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q96K12 775 6.5e-81 Fatty acyl-CoA reductase 2 OS=Homo sapiens GN=FAR2 PE=2 SV=1 PF03015//PF01370//PF01073//PF01118 Male sterility protein//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process GO:0080019//GO:0016620//GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.17682 BP_3 187.25 10.95 1116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17683 BP_3 22.88 0.38 3202 546675278 ERL86514.1 1453 6.8e-158 hypothetical protein D910_03918 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96T76 555 3.8e-55 MMS19 nucleotide excision repair protein homolog OS=Homo sapiens GN=MMS19 PE=1 SV=2 PF17082//PF03274//PF02985 Spindle Pole Component 29//Foamy virus BEL 1/2 protein//HEAT repeat GO:0030474//GO:0016032//GO:0045893 spindle pole body duplication//viral process//positive regulation of transcription, DNA-templated GO:0005515//GO:0005200 protein binding//structural constituent of cytoskeleton GO:0005856//GO:0005823 cytoskeleton//central plaque of spindle pole body KOG1967 DNA repair/transcription protein Mms19 Cluster-8309.17685 BP_3 25.00 2.36 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17687 BP_3 58.07 2.04 1665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02077 SURF4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17689 BP_3 72.68 1.52 2601 546684308 ERL94013.1 983 1.7e-103 hypothetical protein D910_11297 [Dendroctonus ponderosae] -- -- -- -- -- K15446 TRM13, CCDC76 tRNA:m4X modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15446 Q9NUP7 494 3.6e-48 tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens GN=TRMT13 PE=1 SV=2 PF02077//PF11722//PF05206 SURF4 family//CCCH zinc finger in TRM13 protein//Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity GO:0016021 integral component of membrane KOG2811 Uncharacterized conserved protein Cluster-8309.17690 BP_3 60.48 1.26 2598 546684308 ERL94013.1 1221 4.4e-131 hypothetical protein D910_11297 [Dendroctonus ponderosae] -- -- -- -- -- K15446 TRM13, CCDC76 tRNA:m4X modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15446 Q9NUP7 655 7.8e-67 tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens GN=TRMT13 PE=1 SV=2 PF02077//PF11722//PF05206 SURF4 family//CCCH zinc finger in TRM13 protein//Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity GO:0016021 integral component of membrane KOG2811 Uncharacterized conserved protein Cluster-8309.17698 BP_3 1.00 3.49 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1770 BP_3 31.60 4.16 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17700 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17701 BP_3 13.31 0.62 1331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17702 BP_3 2.00 0.33 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17707 BP_3 17.47 0.69 1512 748995298 AJE75671.1 1213 2.2e-130 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09849 954 9.6e-102 Lactase-phlorizin hydrolase OS=Oryctolagus cuniculus GN=LCT PE=1 SV=1 PF00232//PF00150 Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.1771 BP_3 6.40 0.63 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17712 BP_3 257.80 5.47 2562 189240519 XP_971298.2 1682 1.5e-184 PREDICTED: RING finger protein unkempt [Tribolium castaneum] 641657988 XM_008182333.1 256 5.67807e-129 PREDICTED: Acyrthosiphon pisum RING finger protein unkempt (LOC100161020), mRNA -- -- -- -- Q86B79 1434 3.6e-157 RING finger protein unkempt OS=Drosophila melanogaster GN=unk PE=1 SV=1 PF01486//PF00642 K-box region//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003700 metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1595 CCCH-type Zn-finger protein Cluster-8309.17713 BP_3 13.20 0.32 2278 270012593 EFA09041.1 1077 1.9e-114 hypothetical protein TcasGA2_TC006754 [Tribolium castaneum] 462333338 APGK01039007.1 138 1.9873e-63 Dendroctonus ponderosae Seq01039017, whole genome shotgun sequence -- -- -- -- Q86B79 628 9.2e-64 RING finger protein unkempt OS=Drosophila melanogaster GN=unk PE=1 SV=1 PF01486//PF00642//PF08988 K-box region//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Type III secretion system, cytoplasmic E component of needle GO:0009405//GO:0006355 pathogenesis//regulation of transcription, DNA-templated GO:0046872//GO:0003700 metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1595 CCCH-type Zn-finger protein Cluster-8309.17717 BP_3 9.00 0.50 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17727 BP_3 6.00 0.32 1183 478268065 ENN83136.1 336 8.4e-29 hypothetical protein YQE_00503, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17729 BP_3 4.00 1.89 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17733 BP_3 12.07 0.81 1010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17734 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17735 BP_3 36.00 3.72 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17736 BP_3 21.93 1.48 1007 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17741 BP_3 191.00 14.75 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17746 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17748 BP_3 8.45 5.37 364 290909033 ADD70031.1 151 7.3e-08 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17749 BP_3 4.15 0.60 626 150010870 ABR53888.1 139 3.1e-06 odorant binding protein 1 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1775 BP_3 44.18 3.66 874 478254053 ENN74345.1 158 2.7e-08 hypothetical protein YQE_09315, partial [Dendroctonus ponderosae]>gi|546672816|gb|ERL84572.1| hypothetical protein D910_02001 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05221 S-adenosyl-L-homocysteine hydrolase GO:0006555//GO:0006730 methionine metabolic process//one-carbon metabolic process GO:0004013 adenosylhomocysteinase activity -- -- -- -- Cluster-8309.17750 BP_3 71.45 0.49 7290 642911196 XP_008199563.1 2116 2.0e-234 PREDICTED: solute carrier family 12 member 4 isoform X1 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.3761e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 1596 1.7e-175 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF02450//PF13520//PF01218//PF05038//PF03522//PF00324 Lecithin:cholesterol acyltransferase//Amino acid permease//Coproporphyrinogen III oxidase//Cytochrome Cytochrome b558 alpha-subunit//Solute carrier family 12//Amino acid permease GO:0006779//GO:0055114//GO:0055085//GO:0042967//GO:0006810//GO:0003333//GO:0006811//GO:0006865//GO:0006629//GO:0015994 porphyrin-containing compound biosynthetic process//oxidation-reduction process//transmembrane transport//acyl-carrier-protein biosynthetic process//transport//amino acid transmembrane transport//ion transport//amino acid transport//lipid metabolic process//chlorophyll metabolic process GO:0008374//GO:0015171//GO:0020037//GO:0004109//GO:0005215 O-acyltransferase activity//amino acid transmembrane transporter activity//heme binding//coproporphyrinogen oxidase activity//transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.17751 BP_3 54.96 0.91 3211 270014766 EFA11214.1 2668 8.9e-299 hypothetical protein TcasGA2_TC005178 [Tribolium castaneum] 768953561 XM_011617286.1 47 1.08558e-12 PREDICTED: Takifugu rubripes solute carrier family 12 (potassium/chloride transporter), member 6 (slc12a6), mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 1923 8.9e-214 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF13520//PF03522//PF00324 Amino acid permease//Solute carrier family 12//Amino acid permease GO:0003333//GO:0006811//GO:0055085//GO:0006865//GO:0006810 amino acid transmembrane transport//ion transport//transmembrane transport//amino acid transport//transport GO:0015171//GO:0005215 amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.17753 BP_3 238.32 2.76 4461 221115973 XP_002165005.1 962 8.2e-101 PREDICTED: uncharacterized protein LOC100209733 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- Q52V16 273 2.6e-22 Zinc finger Y-chromosomal protein OS=Gorilla gorilla gorilla GN=ZFY PE=3 SV=1 PF03184//PF02150//PF06397//PF13465//PF00096 DDE superfamily endonuclease//RNA polymerases M/15 Kd subunit//Desulfoferrodoxin, N-terminal domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872//GO:0005506//GO:0003676 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//iron ion binding//nucleic acid binding GO:0005730 nucleolus -- -- Cluster-8309.17760 BP_3 361.34 2.12 8515 546681932 ERL91928.1 3803 0.0e+00 hypothetical protein D910_09251 [Dendroctonus ponderosae] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 4.2e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF02257//PF06119//PF07645//PF00008 RFX DNA-binding domain//Nidogen-like//Calcium-binding EGF domain//EGF-like domain GO:0006355//GO:0007160 regulation of transcription, DNA-templated//cell-matrix adhesion GO:0005515//GO:0005509//GO:0003677 protein binding//calcium ion binding//DNA binding -- -- KOG1214 Nidogen and related basement membrane protein proteins Cluster-8309.17761 BP_3 116.50 4.73 1479 642924737 XP_008194418.1 941 7.4e-99 PREDICTED: protein-S-isoprenylcysteine O-methyltransferase [Tribolium castaneum]>gi|270006711|gb|EFA03159.1| hypothetical protein TcasGA2_TC013078 [Tribolium castaneum] 242016078 XM_002428618.1 45 6.38875e-12 Pediculus humanus corporis protein-S-isoprenylcysteine O-methyltransferase, putative, mRNA K00587 ICMT, STE14 protein-S-isoprenylcysteine O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00587 O12947 691 3.0e-71 Protein-S-isoprenylcysteine O-methyltransferase OS=Xenopus laevis GN=icmt PE=2 SV=1 PF00951//PF09174//PF04140 Arterivirus GL envelope glycoprotein//Maf1 regulator//Isoprenylcysteine carboxyl methyltransferase (ICMT) family GO:0006479//GO:0006481//GO:0016480 protein methylation//C-terminal protein methylation//negative regulation of transcription from RNA polymerase III promoter GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021//GO:0005783//GO:0019031 integral component of membrane//endoplasmic reticulum//viral envelope KOG2628 Farnesyl cysteine-carboxyl methyltransferase Cluster-8309.17766 BP_3 289.83 4.87 3158 642911198 XP_008199568.1 4027 0.0e+00 PREDICTED: solute carrier family 12 member 4 isoform X2 [Tribolium castaneum] 768953561 XM_011617286.1 47 1.06746e-12 PREDICTED: Takifugu rubripes solute carrier family 12 (potassium/chloride transporter), member 6 (slc12a6), mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2705 1.8e-304 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006810//GO:0006811//GO:0055085 transport//ion transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.17767 BP_3 23.01 1.59 989 91078614 XP_967493.1 641 3.0e-64 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 38 3.29054e-08 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 Q5R6Q2 279 1.2e-23 Syntaxin-6 OS=Pongo abelii GN=STX6 PE=2 SV=1 PF05739//PF00523//PF00957//PF05478 SNARE domain//Fusion glycoprotein F0//Synaptobrevin//Prominin GO:0006948//GO:0016192 induction by virus of host cell-cell fusion//vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.17772 BP_3 26.00 0.86 1748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17774 BP_3 16.00 0.33 2654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04189 Gcd10p family GO:0030488 tRNA methylation -- -- GO:0031515 tRNA (m1A) methyltransferase complex -- -- Cluster-8309.17775 BP_3 27.55 0.39 3671 642920946 XP_008192625.1 2432 2.3e-271 PREDICTED: amyloid beta A4 precursor protein-binding family B member 2-like isoform X3 [Tribolium castaneum]>gi|270006137|gb|EFA02585.1| hypothetical protein TcasGA2_TC008304 [Tribolium castaneum] -- -- -- -- -- K04530 APBB2, FE65L amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) http://www.genome.jp/dbget-bin/www_bget?ko:K04530 Q9DBR4 789 3.2e-82 Amyloid beta A4 precursor protein-binding family B member 2 OS=Mus musculus GN=Apbb2 PE=1 SV=2 PF08416//PF00640//PF00397 Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID)//WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17776 BP_3 248.45 5.37 2520 642920946 XP_008192625.1 2432 1.6e-271 PREDICTED: amyloid beta A4 precursor protein-binding family B member 2-like isoform X3 [Tribolium castaneum]>gi|270006137|gb|EFA02585.1| hypothetical protein TcasGA2_TC008304 [Tribolium castaneum] -- -- -- -- -- K04530 APBB2, FE65L amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) http://www.genome.jp/dbget-bin/www_bget?ko:K04530 Q9DBR4 789 2.2e-82 Amyloid beta A4 precursor protein-binding family B member 2 OS=Mus musculus GN=Apbb2 PE=1 SV=2 PF00397//PF00640//PF08416 WW domain//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17778 BP_3 20.00 2.27 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17780 BP_3 441.71 17.48 1510 332373106 AEE61694.1 1523 2.5e-166 unknown [Dendroctonus ponderosae]>gi|478251663|gb|ENN72117.1| hypothetical protein YQE_11176, partial [Dendroctonus ponderosae]>gi|478262744|gb|ENN81275.1| hypothetical protein YQE_02311, partial [Dendroctonus ponderosae]>gi|546680917|gb|ERL91091.1| hypothetical protein D910_08433 [Dendroctonus ponderosae] 66823846 XM_640186.1 221 9.47938e-110 Dictyostelium discoideum AX4 protein phosphatase 6 catalytic subunit (ppp6C) mRNA, complete cds K15498 PPP6C serine/threonine-protein phosphatase 6 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15498 Q64620 1374 1.9e-150 Serine/threonine-protein phosphatase 6 catalytic subunit OS=Rattus norvegicus GN=Ppp6c PE=2 SV=2 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0373 Serine/threonine specific protein phosphatase involved in cell cycle control, PP2A-related Cluster-8309.17783 BP_3 106.65 3.49 1763 270015414 EFA11862.1 731 2.0e-74 hypothetical protein TcasGA2_TC005104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17789 BP_3 19.00 0.98 1231 270011382 EFA07830.1 286 5.5e-23 hypothetical protein TcasGA2_TC005399 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13903 PMP-22/EMP/MP20/Claudin tight junction -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17790 BP_3 14.36 0.76 1208 189235061 XP_001814285.1 675 4.2e-68 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49711 261 1.8e-21 Transcriptional repressor CTCF OS=Homo sapiens GN=CTCF PE=1 SV=1 PF13912//PF01844//PF13465//PF00096 C2H2-type zinc finger//HNH endonuclease//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003676//GO:0004519//GO:0046872 nucleic acid binding//endonuclease activity//metal ion binding -- -- -- -- Cluster-8309.17791 BP_3 44.97 1.84 1472 91091644 XP_970770.1 198 1.0e-12 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000890|gb|EEZ97337.1| hypothetical protein TcasGA2_TC011149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83994 140 2.3e-07 Cuticle protein 18.6, isoform A OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.17792 BP_3 67.82 0.61 5650 642913582 XP_008201072.1 3273 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 21 [Tribolium castaneum] -- -- -- -- -- K18025 PTPN14_21 tyrosine-protein phosphatase non-receptor type 14/21 http://www.genome.jp/dbget-bin/www_bget?ko:K18025 Q15678 648 1.1e-65 Tyrosine-protein phosphatase non-receptor type 14 OS=Homo sapiens GN=PTPN14 PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.17797 BP_3 69.00 1.13 3244 158262721 NP_001103418.1 2344 3.3e-261 nicotinic acetylcholine receptor beta 1 subunit isoform 1 precursor [Tribolium castaneum]>gi|154810995|gb|ABS86916.1| nicotinic acetylcholine receptor subunit beta1 [Tribolium castaneum]>gi|270015608|gb|EFA12056.1| nicotinic acetylcholine receptor subunit beta1 [Tribolium castaneum] 807015737 XM_012301063.1 344 8.68486e-178 PREDICTED: Ceratitis capitata acetylcholine receptor subunit beta-like 1 (LOC101461364), mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P04755 2181 1.1e-243 Acetylcholine receptor subunit beta-like 1 OS=Drosophila melanogaster GN=nAChRbeta1 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006812//GO:0006810//GO:0007165 ion transport//cation transport//transport//signal transduction GO:0005230//GO:0004889 extracellular ligand-gated ion channel activity//acetylcholine-activated cation-selective channel activity GO:0045211//GO:0030054//GO:0016020//GO:0016021//GO:0005886 postsynaptic membrane//cell junction//membrane//integral component of membrane//plasma membrane KOG3645 Acetylcholine receptor Cluster-8309.17799 BP_3 32.66 0.71 2507 668462962 KFB50405.1 685 6.0e-69 AGAP005747-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- Q96NJ6 204 1.5e-14 Zinc finger protein 3 homolog OS=Homo sapiens GN=ZFP3 PE=2 SV=1 PF00651//PF13912//PF00096//PF13465 BTB/POZ domain//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.178 BP_3 9.57 0.34 1647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04131 Putative N-acetylmannosamine-6-phosphate epimerase GO:0006051//GO:0006040 N-acetylmannosamine metabolic process//amino sugar metabolic process GO:0047465 N-acylglucosamine-6-phosphate 2-epimerase activity -- -- -- -- Cluster-8309.1780 BP_3 5.00 0.34 1005 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17800 BP_3 3.00 0.78 477 642940144 XP_008200104.1 506 6.5e-49 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H269 327 1.5e-29 Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens GN=VPS16 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.17803 BP_3 4.00 0.38 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17804 BP_3 13.00 0.42 1784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17805 BP_3 3.40 0.34 768 290909033 ADD70031.1 362 5.3e-32 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- P54193 143 5.4e-08 General odorant-binding protein 83a OS=Drosophila melanogaster GN=Obp83a PE=1 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.17809 BP_3 7.00 1.92 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17810 BP_3 12.07 1.16 793 642935524 XP_008198045.1 307 1.3e-25 PREDICTED: casein kinase I isoform alpha isoform X3 [Tribolium castaneum] 240957921 XM_002400117.1 122 5.27427e-55 Ixodes scapularis casein kinase, putative, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67829 292 2.9e-25 Casein kinase I isoform alpha OS=Ovis aries GN=CSNK1A1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1163 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.17813 BP_3 1049.51 6.64 7915 170286893 BAG13448.1 5658 0.0e+00 chitinase [Monochamus alternatus] 170286892 AB428669.1 3476 0 Monochamus alternatus MaChiPm1 mRNA for chitinase, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W5U2 1545 1.5e-169 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607//PF00704//PF03970 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18//Herpesvirus UL37 tegument protein GO:0019068//GO:0005975//GO:0006030 virion assembly//carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region -- -- Cluster-8309.17815 BP_3 163.59 3.13 2807 91088573 XP_973123.1 1442 1.1e-156 PREDICTED: ubiA prenyltransferase domain-containing protein 1 homolog [Tribolium castaneum]>gi|270012242|gb|EFA08690.1| hypothetical protein TcasGA2_TC006361 [Tribolium castaneum] 642931909 XM_968030.2 316 2.756e-162 PREDICTED: Tribolium castaneum ubiA prenyltransferase domain-containing protein 1 homolog (LOC661899), mRNA -- -- -- -- Q9V3R8 1086 8.8e-117 UbiA prenyltransferase domain-containing protein 1 homolog OS=Drosophila melanogaster GN=heix PE=2 SV=1 PF01496//PF15812//PF16326//PF04977//PF06009//PF05531//PF07851//PF04513//PF02601//PF17078//PF08912//PF06305//PF03462//PF01040//PF00804//PF04111//PF03255//PF03965 V-type ATPase 116kDa subunit family//Melanoregulin//ABC transporter C-terminal domain//Septum formation initiator//Laminin Domain II//Nucleopolyhedrovirus P10 protein//TMPIT-like protein//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//SWI5-dependent HO expression protein 3//Rho Binding//Protein of unknown function (DUF1049)//PCRF domain//UbiA prenyltransferase family//Syntaxin//Autophagy protein Apg6//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Penicillinase repressor GO:0006308//GO:0007155//GO:0015991//GO:0006449//GO:0007049//GO:0045892//GO:0006914//GO:0032402//GO:0051028//GO:0048309//GO:0006633//GO:0015992//GO:0006415//GO:0006090 DNA catabolic process//cell adhesion//ATP hydrolysis coupled proton transport//regulation of translational termination//cell cycle//negative regulation of transcription, DNA-templated//autophagy//melanosome transport//mRNA transport//endoplasmic reticulum inheritance//fatty acid biosynthetic process//proton transport//translational termination//pyruvate metabolic process GO:0008855//GO:0016149//GO:0003677//GO:0015078//GO:0005198//GO:0004659//GO:0003989//GO:0017048 exodeoxyribonuclease VII activity//translation release factor activity, codon specific//DNA binding//hydrogen ion transmembrane transporter activity//structural molecule activity//prenyltransferase activity//acetyl-CoA carboxylase activity//Rho GTPase binding GO:0033179//GO:0016020//GO:0019031//GO:0009317//GO:0005737//GO:0005840//GO:0016021//GO:0005887//GO:0042470//GO:0018444//GO:0009318//GO:0019028 proton-transporting V-type ATPase, V0 domain//membrane//viral envelope//acetyl-CoA carboxylase complex//cytoplasm//ribosome//integral component of membrane//integral component of plasma membrane//melanosome//translation release factor complex//exodeoxyribonuclease VII complex//viral capsid KOG3433 Protein involved in meiotic recombination/predicted coiled-coil protein Cluster-8309.17818 BP_3 1249.26 19.88 3321 91088573 XP_973123.1 1442 1.3e-156 PREDICTED: ubiA prenyltransferase domain-containing protein 1 homolog [Tribolium castaneum]>gi|270012242|gb|EFA08690.1| hypothetical protein TcasGA2_TC006361 [Tribolium castaneum] 642931909 XM_968030.2 316 3.26722e-162 PREDICTED: Tribolium castaneum ubiA prenyltransferase domain-containing protein 1 homolog (LOC661899), mRNA -- -- -- -- Q9V3R8 1086 1.0e-116 UbiA prenyltransferase domain-containing protein 1 homolog OS=Drosophila melanogaster GN=heix PE=2 SV=1 PF01040//PF06331 UbiA prenyltransferase family//Transcription factor TFIIH complex subunit Tfb5 GO:0006289//GO:0006355 nucleotide-excision repair//regulation of transcription, DNA-templated GO:0004659 prenyltransferase activity GO:0000439//GO:0016021 core TFIIH complex//integral component of membrane KOG3362 Predicted BBOX Zn-finger protein Cluster-8309.17819 BP_3 119.36 3.33 2018 642918952 XP_974118.3 1514 3.6e-165 PREDICTED: protein king tubby [Tribolium castaneum]>gi|270005704|gb|EFA02152.1| hypothetical protein TcasGA2_TC007804 [Tribolium castaneum] 820849454 XM_003693782.2 230 1.26543e-114 PREDICTED: Apis florea protein king tubby (LOC100866222), mRNA -- -- -- -- Q7PZK5 976 3.6e-104 Protein king tubby OS=Anopheles gambiae GN=king-tubby PE=3 SV=4 -- -- -- -- -- -- -- -- KOG2502 Tub family proteins Cluster-8309.1782 BP_3 24.32 0.32 3977 642921861 XP_008192921.1 1905 3.3e-210 PREDICTED: diacylglycerol kinase eta [Tribolium castaneum] 759038589 XM_011353529.1 92 1.30066e-37 PREDICTED: Cerapachys biroi diacylglycerol kinase eta (LOC105287764), transcript variant X8, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 B3LXF2 669 2.8e-68 Diacylglycerol kinase eta OS=Drosophila ananassae GN=GF18176 PE=3 SV=2 PF02198//PF00609//PF00536//PF07647//PF02017 Sterile alpha motif (SAM)/Pointed domain//Diacylglycerol kinase accessory domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//CIDE-N domain GO:0046486//GO:0006915//GO:0007205//GO:0009395 glycerolipid metabolic process//apoptotic process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process GO:0043565//GO:0005515//GO:0004143 sequence-specific DNA binding//protein binding//diacylglycerol kinase activity GO:0005622//GO:0005634 intracellular//nucleus KOG1170 Diacylglycerol kinase Cluster-8309.17828 BP_3 48.06 2.50 1220 270008966 EFA05414.1 204 1.8e-13 hypothetical protein TcasGA2_TC015590 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15172 Prolactin-releasing peptide GO:0007165 signal transduction GO:0005179 hormone activity -- -- -- -- Cluster-8309.17830 BP_3 33.22 0.81 2267 91081907 XP_970048.1 1659 6.3e-182 PREDICTED: myotubularin-related protein 9 isoform X2 [Tribolium castaneum]>gi|270007347|gb|EFA03795.1| hypothetical protein TcasGA2_TC013907 [Tribolium castaneum] -- -- -- -- -- K18084 MTMR9 myotubularin-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18084 Q96QG7 1167 2.9e-126 Myotubularin-related protein 9 OS=Homo sapiens GN=MTMR9 PE=1 SV=1 -- -- GO:0016311 dephosphorylation GO:0016791 phosphatase activity -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.17831 BP_3 429.00 12.09 2002 91077510 XP_969609.1 1304 8.1e-141 PREDICTED: microfibrillar-associated protein 1 [Tribolium castaneum]>gi|270001604|gb|EEZ98051.1| hypothetical protein TcasGA2_TC000456 [Tribolium castaneum] 642914056 XM_964516.2 278 2.60416e-141 PREDICTED: Tribolium castaneum microfibrillar-associated protein 1 (LOC658105), mRNA K13110 MFAP1 microfibrillar-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13110 P55080 695 1.4e-71 Microfibrillar-associated protein 1 OS=Gallus gallus GN=MFAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1425 Microfibrillar-associated protein MFAP1 Cluster-8309.17833 BP_3 31.67 1.14 1636 478250641 ENN71133.1 467 7.5e-44 hypothetical protein YQE_12064, partial [Dendroctonus ponderosae]>gi|546674776|gb|ERL86073.1| hypothetical protein D910_03487 [Dendroctonus ponderosae] -- -- -- -- -- K03103 MINPP1 multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K03103 -- -- -- -- PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- -- -- Cluster-8309.17838 BP_3 393.40 6.26 3323 815897996 XP_012249713.1 1799 5.3e-198 PREDICTED: histone deacetylase 6 [Bombus impatiens] -- -- -- -- -- K11407 HDAC6 histone deacetylase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11407 Q9Z2V5 1328 9.1e-145 Histone deacetylase 6 OS=Mus musculus GN=Hdac6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.17846 BP_3 30.96 0.65 2574 478252154 ENN72582.1 1183 1.1e-126 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 A6H751 837 6.0e-88 Folylpolyglutamate synthase, mitochondrial OS=Bos taurus GN=FPGS PE=2 SV=1 PF08245//PF02875 Mur ligase middle domain//Mur ligase family, glutamate ligase domain GO:0009058 biosynthetic process GO:0016874//GO:0005524 ligase activity//ATP binding -- -- KOG2525 Folylpolyglutamate synthase Cluster-8309.17848 BP_3 47.05 1.02 2510 478252154 ENN72582.1 944 5.6e-99 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 P48760 699 5.9e-72 Folylpolyglutamate synthase, mitochondrial OS=Mus musculus GN=Fpgs PE=1 SV=3 PF02023//PF08245 SCAN domain//Mur ligase middle domain GO:0009058//GO:0006355 biosynthetic process//regulation of transcription, DNA-templated GO:0003700//GO:0005524 transcription factor activity, sequence-specific DNA binding//ATP binding GO:0005667 transcription factor complex KOG2525 Folylpolyglutamate synthase Cluster-8309.17850 BP_3 433.43 9.37 2521 478252154 ENN72582.1 1192 9.9e-128 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 P48760 845 7.0e-89 Folylpolyglutamate synthase, mitochondrial OS=Mus musculus GN=Fpgs PE=1 SV=3 PF02875//PF08245 Mur ligase family, glutamate ligase domain//Mur ligase middle domain GO:0009058 biosynthetic process GO:0005524//GO:0016874 ATP binding//ligase activity -- -- KOG2525 Folylpolyglutamate synthase Cluster-8309.17853 BP_3 36.00 1.55 1413 195356866 XP_002044858.1 482 1.2e-45 GM16910 [Drosophila sechellia]>gi|194122923|gb|EDW44966.1| GM16910 [Drosophila sechellia] 801397371 XM_012203695.1 131 9.5052e-60 PREDICTED: Atta cephalotes histone H2B (LOC105622276), mRNA K11252 H2B histone H2B http://www.genome.jp/dbget-bin/www_bget?ko:K11252 P21897 449 3.3e-43 Histone H2B OS=Chironomus thummi thummi PE=3 SV=2 PF00125//PF03847 Core histone H2A/H2B/H3/H4//Transcription initiation factor TFIID subunit A GO:0006352//GO:0006334 DNA-templated transcription, initiation//nucleosome assembly GO:0046982//GO:0003677 protein heterodimerization activity//DNA binding GO:0005669//GO:0005634//GO:0000786 transcription factor TFIID complex//nucleus//nucleosome -- -- Cluster-8309.17855 BP_3 109.17 3.65 1735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17859 BP_3 32.59 2.09 1043 91083631 XP_970382.1 1150 3.0e-123 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] -- -- -- -- -- K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 808 5.6e-85 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF02233//PF01752 NAD(P) transhydrogenase beta subunit//Collagenase GO:0006508//GO:0055114//GO:0015992//GO:0006769//GO:0046497 proteolysis//oxidation-reduction process//proton transport//nicotinamide metabolic process//nicotinate nucleotide metabolic process GO:0008270//GO:0004252//GO:0050661//GO:0008750 zinc ion binding//serine-type endopeptidase activity//NADP binding//NAD(P)+ transhydrogenase (AB-specific) activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.17867 BP_3 9.00 8.53 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17870 BP_3 37.55 6.95 552 820805540 AKG92761.1 203 1.0e-13 mnt2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00010//PF07448 Helix-loop-helix DNA-binding domain//Secreted phosphoprotein 24 (Spp-24) GO:0046849 bone remodeling GO:0046983 protein dimerization activity GO:0005576 extracellular region -- -- Cluster-8309.17872 BP_3 53.00 0.55 4966 478254095 ENN74383.1 2551 5.1e-285 hypothetical protein YQE_09040, partial [Dendroctonus ponderosae] -- -- -- -- -- K02332 POLG1 DNA polymerase gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02332 Q27607 2164 1.6e-241 DNA polymerase subunit gamma-1, mitochondrial OS=Drosophila melanogaster GN=tam PE=1 SV=2 PF00476//PF01300//PF07834//PF01176//PF01612 DNA polymerase family A//Telomere recombination//RanGAP1 C-terminal domain//Translation initiation factor 1A / IF-1//3'-5' exonuclease GO:0007165//GO:0006446//GO:0006139//GO:0006413//GO:0006260 signal transduction//regulation of translational initiation//nucleobase-containing compound metabolic process//translational initiation//DNA replication GO:0003723//GO:0005096//GO:0003677//GO:0003743//GO:0003887//GO:0008408//GO:0003676//GO:0003725 RNA binding//GTPase activator activity//DNA binding//translation initiation factor activity//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//nucleic acid binding//double-stranded RNA binding GO:0042575//GO:0005840 DNA polymerase complex//ribosome KOG3657 Mitochondrial DNA polymerase gamma, catalytic subunit Cluster-8309.17876 BP_3 259.00 9.06 1669 646712022 KDR16973.1 1438 1.9e-156 THO complex subunit 3 [Zootermopsis nevadensis] 242008837 XM_002425159.1 194 1.07265e-94 Pediculus humanus corporis THO complex subunit, putative, mRNA K12880 THOC3 THO complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12880 Q96J01 1187 1.0e-128 THO complex subunit 3 OS=Homo sapiens GN=THOC3 PE=1 SV=1 PF00400//PF00930//PF04053 WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Coatomer WD associated region GO:0006508//GO:0016192//GO:0006886 proteolysis//vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG1407 WD40 repeat protein Cluster-8309.17878 BP_3 30.78 0.38 4221 91093417 XP_967777.1 670 5.6e-67 PREDICTED: RNA-binding protein 8A [Tribolium castaneum]>gi|270015421|gb|EFA11869.1| tsunagi [Tribolium castaneum] -- -- -- -- -- K12876 RBM8A, Y14 RNA-binding protein 8A http://www.genome.jp/dbget-bin/www_bget?ko:K12876 Q5D018 455 2.0e-43 RNA-binding protein 8A OS=Danio rerio GN=rbm8a PE=2 SV=1 PF00478//PF00076//PF04799 IMP dehydrogenase / GMP reductase domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//fzo-like conserved region GO:0008053//GO:0055114//GO:0006396 mitochondrial fusion//oxidation-reduction process//RNA processing GO:0003723//GO:0003824//GO:0003924//GO:0000166//GO:0003676 RNA binding//catalytic activity//GTPase activity//nucleotide binding//nucleic acid binding GO:0005634//GO:0016021//GO:0005741//GO:0005737 nucleus//integral component of membrane//mitochondrial outer membrane//cytoplasm KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily) Cluster-8309.17882 BP_3 170.00 9.85 1124 91084479 XP_971343.1 878 1.1e-91 PREDICTED: nudC domain-containing protein 3 [Tribolium castaneum]>gi|270008680|gb|EFA05128.1| hypothetical protein TcasGA2_TC015243 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RB75 321 1.8e-28 NudC domain-containing protein 3 OS=Pongo abelii GN=NUDCD3 PE=2 SV=1 PF01119 DNA mismatch repair protein, C-terminal domain GO:0006298 mismatch repair GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.17886 BP_3 316.00 26.66 863 91089255 XP_969352.1 456 7.4e-43 PREDICTED: 39S ribosomal protein L12, mitochondrial [Tribolium castaneum]>gi|270011463|gb|EFA07911.1| hypothetical protein TcasGA2_TC005486 [Tribolium castaneum] -- -- -- -- -- K02935 RP-L7, MRPL12, rplL large subunit ribosomal protein L7/L12 http://www.genome.jp/dbget-bin/www_bget?ko:K02935 P52815 190 2.1e-13 39S ribosomal protein L12, mitochondrial OS=Homo sapiens GN=MRPL12 PE=1 SV=2 PF16320//PF00542 Ribosomal protein L7/L12 dimerisation domain//Ribosomal protein L7/L12 C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1715 Mitochondrial/chloroplast ribosomal protein L12 Cluster-8309.17889 BP_3 141.96 3.35 2332 642925115 XP_008194175.1 743 1.1e-75 PREDICTED: uncharacterized protein LOC103313218 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VA00 131 4.0e-06 Protein zwilch OS=Drosophila melanogaster GN=zwilch PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17891 BP_3 110.64 5.12 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17893 BP_3 8.86 0.82 812 642927673 XP_008195359.1 998 9.9e-106 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase 1 [Tribolium castaneum] -- -- -- -- -- K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q01583 448 2.4e-43 Diacylglycerol kinase 1 OS=Drosophila melanogaster GN=Dgk PE=2 SV=5 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17895 BP_3 15.00 1.62 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17896 BP_3 3.00 0.32 741 795017237 XP_011858781.1 137 6.2e-06 PREDICTED: uncharacterized protein LOC105556307 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.179 BP_3 15.90 0.41 2162 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1790 BP_3 70.00 1.73 2243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17901 BP_3 21.22 0.80 1563 642936176 XP_008198328.1 893 2.9e-93 PREDICTED: fibronectin type III domain-containing protein 4 [Tribolium castaneum] 194880702 XM_001974468.1 91 1.81432e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.17905 BP_3 18.00 1.65 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17908 BP_3 1132.64 17.76 3365 642918572 XP_008199322.1 1470 7.6e-160 PREDICTED: ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12492 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12492 Q8N6T3 527 7.0e-52 ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens GN=ARFGAP1 PE=1 SV=2 PF01825//PF01412 GPCR proteolysis site, GPS, motif//Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity GO:0016020 membrane KOG0704 ADP-ribosylation factor GTPase activator Cluster-8309.17909 BP_3 25.00 0.72 1969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17916 BP_3 38.45 0.31 6328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07928//PF08047 Vps54-like protein//Histidine operon leader peptide GO:0042147//GO:0000105 retrograde transport, endosome to Golgi//histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.17922 BP_3 24.82 1.74 978 642915536 XP_008190656.1 507 1.0e-48 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] 571572834 XM_006565667.1 109 1.10549e-47 PREDICTED: Apis mellifera uncharacterized FAM18-like protein CG5021-like (LOC408503), transcript variant X5, mRNA -- -- -- -- Q8IQC1 430 3.6e-41 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.17923 BP_3 6.43 3.01 393 642915536 XP_008190656.1 247 5.8e-19 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IQC1 136 1.8e-07 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 -- -- -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17927 BP_3 1.00 4.43 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17928 BP_3 8.00 0.48 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17929 BP_3 9.00 1.14 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17930 BP_3 825.33 9.27 4585 -- -- -- -- -- 642916579 XM_008193556.1 49 1.20238e-13 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein L (LOC657712), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17940 BP_3 41.52 0.63 3469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03523 Macrophage scavenger receptor GO:0007165//GO:0006898 signal transduction//receptor-mediated endocytosis GO:0005044 scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.17941 BP_3 1431.61 22.58 3348 91091374 XP_973014.1 2065 7.7e-229 PREDICTED: FACT complex subunit Ssrp1 [Tribolium castaneum] 759066034 XM_011344158.1 265 7.38715e-134 PREDICTED: Cerapachys biroi FACT complex subunit Ssrp1 (LOC105282288), mRNA K09272 SSRP1 structure-specific recognition protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09272 Q293F6 1703 3.0e-188 FACT complex subunit Ssrp1 OS=Drosophila pseudoobscura pseudoobscura GN=Ssrp PE=3 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG0526 Nucleosome-binding factor SPN, POB3 subunit Cluster-8309.17942 BP_3 4.00 4.04 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17943 BP_3 13.00 1.23 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17947 BP_3 3.00 0.80 472 546679341 ERL89816.1 279 1.4e-22 hypothetical protein D910_07177 [Dendroctonus ponderosae] 743899635 XM_011044803.1 49 1.16144e-14 PREDICTED: Populus euphratica splicing factor 3B subunit 1 (LOC105138652), mRNA K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O75533 242 1.1e-19 Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.1795 BP_3 4.00 0.45 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17951 BP_3 8.00 0.62 918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17955 BP_3 4.00 0.45 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17958 BP_3 32.93 1.09 1752 478252789 ENN73182.1 1064 4.8e-113 hypothetical protein YQE_10236, partial [Dendroctonus ponderosae]>gi|546682445|gb|ERL92378.1| hypothetical protein D910_09692 [Dendroctonus ponderosae] -- -- -- -- -- K15108 SLC25A19, DNC, TPC1 solute carrier family 25 (mitochondrial thiamine pyrophosphate transporter), member 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15108 Q5IS35 624 2.1e-63 Mitochondrial thiamine pyrophosphate carrier OS=Macaca fascicularis GN=SLC25A19 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0752 Mitochondrial solute carrier protein Cluster-8309.17959 BP_3 11.19 0.39 1661 91092070 XP_970936.1 1008 1.4e-106 PREDICTED: mitochondrial thiamine pyrophosphate carrier [Tribolium castaneum]>gi|270004683|gb|EFA01131.1| hypothetical protein TcasGA2_TC010344 [Tribolium castaneum] -- -- -- -- -- K15108 SLC25A19, DNC, TPC1 solute carrier family 25 (mitochondrial thiamine pyrophosphate transporter), member 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15108 Q5IS35 602 6.9e-61 Mitochondrial thiamine pyrophosphate carrier OS=Macaca fascicularis GN=SLC25A19 PE=2 SV=1 PF00023 Ankyrin repeat GO:0006810 transport GO:0005515 protein binding GO:0016020 membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.17960 BP_3 7.13 0.51 962 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09599//PF07776 Salmonella-Shigella invasin protein C (IpaC_SipC)//Zinc-finger associated domain (zf-AD) GO:0009405 pathogenesis GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.17961 BP_3 28.93 0.37 4112 270003759 EFA00207.1 1137 3.8e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.90718e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.6e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.17962 BP_3 17.97 4.32 492 91084873 XP_968370.1 525 4.2e-51 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270009235|gb|EFA05683.1| cytochrome P450 6BK11 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 361 1.8e-33 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0046872//GO:0016491//GO:0005506//GO:0016705 heme binding//metal ion binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.17963 BP_3 3.00 1.86 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17964 BP_3 11.00 0.34 1865 282847465 NP_001164281.1 213 2.4e-14 cytochrome P450 CYP6BK17 [Tribolium castaneum]>gi|161344971|gb|ABX64450.1| cytochrome P450 CYP6BK17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15681 Lymphocyte activation family X GO:0006955//GO:0051249 immune response//regulation of lymphocyte activation GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.17969 BP_3 35.88 1.57 1394 741829513 AJA91072.1 1294 8.1e-140 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 865 1.9e-91 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0051249//GO:0006955//GO:0055114 regulation of lymphocyte activation//immune response//oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.17970 BP_3 86.57 2.61 1893 741829513 AJA91072.1 1587 1.2e-173 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 1062 3.6e-114 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.17974 BP_3 5499.69 78.14 3684 642934488 XP_008197685.1 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934490|ref|XP_008197686.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934492|ref|XP_008197687.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|270013516|gb|EFA09964.1| hypothetical protein TcasGA2_TC012121 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54316 599 3.4e-60 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 PF11023//PF00517 Zinc-ribbon containing domain//Retroviral envelope protein -- -- GO:0005198//GO:0003824 structural molecule activity//catalytic activity GO:0019031//GO:0005887 viral envelope//integral component of plasma membrane -- -- Cluster-8309.17975 BP_3 6.74 0.44 1031 642936810 XP_008199625.1 550 1.1e-53 PREDICTED: uncharacterized protein LOC103314713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03615//PF00589 GCM motif protein//Phage integrase family GO:0015074//GO:0006310//GO:0006355 DNA integration//DNA recombination//regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.17977 BP_3 412.46 7.39 2981 91078882 XP_972954.1 2710 1.1e-303 PREDICTED: ubiquitin carboxyl-terminal hydrolase 36 [Tribolium castaneum]>gi|270003709|gb|EFA00157.1| hypothetical protein TcasGA2_TC002978 [Tribolium castaneum] -- -- -- -- -- K11855 USP36_42 ubiquitin carboxyl-terminal hydrolase 36/42 http://www.genome.jp/dbget-bin/www_bget?ko:K11855 B3M3M6 1148 6.1e-124 Ubiquitin carboxyl-terminal hydrolase 36 OS=Drosophila ananassae GN=Usp36 PE=3 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0006511//GO:0006508 protein deubiquitination//ubiquitin-dependent protein catabolic process//proteolysis GO:0004221//GO:0008234//GO:0036459 obsolete ubiquitin thiolesterase activity//cysteine-type peptidase activity//ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.17978 BP_3 1.00 0.77 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17984 BP_3 52.00 0.96 2909 850300312 XP_012861623.1 296 9.0e-24 PREDICTED: zinc finger protein 2 homolog [Echinops telfairi] -- -- -- -- -- -- -- -- -- P51523 276 7.7e-23 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF01363//PF13912//PF05191//PF13465//PF00096//PF05495 FYVE zinc finger//C2H2-type zinc finger//Adenylate kinase, active site lid//Zinc-finger double domain//Zinc finger, C2H2 type//CHY zinc finger GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0004017//GO:0046872 zinc ion binding//adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.17986 BP_3 8.08 1.71 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17987 BP_3 103.11 1.79 3064 270015294 EFA11742.1 1455 3.8e-158 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.17990 BP_3 68.06 2.85 1442 91094469 XP_967482.1 796 4.7e-82 PREDICTED: pre-mRNA-splicing factor 38B [Tribolium castaneum]>gi|270000754|gb|EEZ97201.1| hypothetical protein TcasGA2_TC004390 [Tribolium castaneum] -- -- -- -- -- K12850 PRPF38B pre-mRNA-splicing factor 38B http://www.genome.jp/dbget-bin/www_bget?ko:K12850 Q5VTL8 649 2.1e-66 Pre-mRNA-splicing factor 38B OS=Homo sapiens GN=PRPF38B PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2888 Putative RNA binding protein Cluster-8309.17991 BP_3 33.22 1.29 1531 795010886 XP_011869570.1 497 2.3e-47 PREDICTED: putative nuclease HARBI1, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q96MB7 186 1.1e-12 Putative nuclease HARBI1 OS=Homo sapiens GN=HARBI1 PE=1 SV=1 PF04827//PF01609//PF09339//PF02796 Plant transposon protein//Transposase DDE domain//IclR helix-turn-helix domain//Helix-turn-helix domain of resolvase GO:0006313//GO:0006355//GO:0006310 transposition, DNA-mediated//regulation of transcription, DNA-templated//DNA recombination GO:0004803//GO:0000150//GO:0003677//GO:0016788 transposase activity//recombinase activity//DNA binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.17993 BP_3 23.51 0.75 1800 642914172 XP_008201574.1 423 1.0e-38 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15182 Otospiralin GO:0007605 sensory perception of sound -- -- -- -- -- -- Cluster-8309.17998 BP_3 9.00 0.33 1624 641678700 XP_008188260.1 163 1.3e-08 PREDICTED: uncharacterized protein LOC103310749 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17999 BP_3 36.59 0.58 3335 546682082 ERL92068.1 2350 6.9e-262 hypothetical protein D910_09390 [Dendroctonus ponderosae] -- -- -- -- -- K12487 GIT2 G protein-coupled receptor kinase interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12487 Q14161 950 6.2e-101 ARF GTPase-activating protein GIT2 OS=Homo sapiens GN=GIT2 PE=1 SV=2 PF10392//PF01412//PF06005//PF13851//PF06156//PF13606//PF01166//PF03836//PF00023 Golgi transport complex subunit 5//Putative GTPase activating protein for Arf//Protein of unknown function (DUF904)//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF972)//Ankyrin repeat//TSC-22/dip/bun family//RasGAP C-terminus//Ankyrin repeat GO:0043093//GO:0000917//GO:0007264//GO:0006260//GO:0006355//GO:0048870//GO:0006891 FtsZ-dependent cytokinesis//barrier septum assembly//small GTPase mediated signal transduction//DNA replication//regulation of transcription, DNA-templated//cell motility//intra-Golgi vesicle-mediated transport GO:0003700//GO:0005515//GO:0005096 transcription factor activity, sequence-specific DNA binding//protein binding//GTPase activator activity GO:0005737//GO:0017119//GO:0005667//GO:0031514 cytoplasm//Golgi transport complex//transcription factor complex//motile cilium KOG0818 GTPase-activating proteins of the GIT family Cluster-8309.18 BP_3 35.00 1.04 1909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18001 BP_3 14.00 0.36 2170 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18005 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18006 BP_3 30.45 1.64 1188 270007525 EFA03973.1 630 6.8e-63 hypothetical protein TcasGA2_TC014120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VZD2 474 3.4e-46 Probable RNA methyltransferase CG11342 OS=Drosophila melanogaster GN=CG11342 PE=3 SV=1 PF06859 Bicoid-interacting protein 3 (Bin3) -- -- GO:0008168 methyltransferase activity -- -- KOG2899 Predicted methyltransferase Cluster-8309.18008 BP_3 13.00 2.13 586 -- -- -- -- -- 462289926 APGK01054630.1 43 3.16023e-11 Dendroctonus ponderosae Seq01054640, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18011 BP_3 1.00 0.64 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18017 BP_3 52.73 1.75 1744 642936411 XP_972396.2 569 1.2e-55 PREDICTED: zinc finger protein 714 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A2VDP4 326 7.3e-29 Zinc finger protein 567 OS=Bos taurus GN=ZNF567 PE=2 SV=1 PF13465//PF00096//PF13912//PF04810//PF02892//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat -- -- Cluster-8309.18021 BP_3 3690.74 36.62 5149 642916535 XP_008191598.1 1175 1.9e-125 PREDICTED: probable serine/threonine-protein kinase nek3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W2E1 395 2.2e-36 Protein stum OS=Drosophila melanogaster GN=stum PE=2 SV=3 PF14525//PF02325//PF00560 AraC-binding-like domain//YGGT family//Leucine Rich Repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.18022 BP_3 702.00 83.69 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18026 BP_3 6.00 0.56 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1803 BP_3 8.00 0.54 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18032 BP_3 11.00 0.73 1017 659114130 AID61753.1 936 1.9e-98 fructose 1,6-biphosphate-aldolase A [Fenneropenaeus chinensis] 724970560 XM_010359278.1 252 3.6972e-127 PREDICTED: Rhinopithecus roxellana fructose-bisphosphate aldolase-like (LOC104659120), partial mRNA K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P07764 770 1.4e-80 Fructose-bisphosphate aldolase OS=Drosophila melanogaster GN=Ald PE=1 SV=5 PF00274 Fructose-bisphosphate aldolase class-I GO:0006098//GO:0006096//GO:0006020//GO:0015976//GO:0006094//GO:0006000//GO:0006013 pentose-phosphate shunt//glycolytic process//inositol metabolic process//carbon utilization//gluconeogenesis//fructose metabolic process//mannose metabolic process GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8309.18034 BP_3 54.29 1.59 1942 642936481 XP_008198455.1 1480 3.1e-161 PREDICTED: beta-1,3-glucosyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13675 B3GALTL UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13675 Q8BHT6 1156 4.7e-125 Beta-1,3-glucosyltransferase OS=Mus musculus GN=B3galtl PE=2 SV=3 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.18037 BP_3 11.70 0.34 1931 91095049 XP_972102.1 649 7.0e-65 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 339 2.5e-30 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18038 BP_3 23.00 0.32 3783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05777 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) GO:0007617 mating behavior -- -- GO:0005576 extracellular region -- -- Cluster-8309.18039 BP_3 37.38 0.57 3475 642919403 XP_008191855.1 1866 9.5e-206 PREDICTED: ubiquitin carboxyl-terminal hydrolase 46 [Tribolium castaneum] 642919402 XM_008193633.1 551 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 46 (LOC663037), mRNA K11842 USP12_46 ubiquitin carboxyl-terminal hydrolase 12/46 http://www.genome.jp/dbget-bin/www_bget?ko:K11842 Q5RBQ4 1419 2.7e-155 Ubiquitin carboxyl-terminal hydrolase 46 OS=Pongo abelii GN=USP46 PE=2 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.18040 BP_3 158.00 8.45 1193 91078372 XP_974116.1 963 1.7e-101 PREDICTED: uncharacterized protein C9orf78 [Tribolium castaneum]>gi|270003886|gb|EFA00334.1| hypothetical protein TcasGA2_TC003173 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZ63 544 2.6e-54 Uncharacterized protein C9orf78 OS=Homo sapiens GN=C9orf78 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3345 Uncharacterized conserved protein Cluster-8309.18042 BP_3 30.04 0.51 3126 642924396 XP_008194278.1 903 4.0e-94 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] -- -- -- -- -- K06637 BUB1B, BUBR1, MAD3L mitotic checkpoint serine/threonine-protein kinase BUB1 beta http://www.genome.jp/dbget-bin/www_bget?ko:K06637 Q9Z1S0 371 8.0e-34 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Mus musculus GN=Bub1b PE=1 SV=2 PF03852 DNA mismatch endonuclease Vsr GO:0006298 mismatch repair GO:0004519 endonuclease activity -- -- KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.18045 BP_3 36.98 1.79 1289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18046 BP_3 138.00 10.59 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18047 BP_3 414.26 3.80 5550 189236995 XP_970755.2 2750 4.7e-308 PREDICTED: uncharacterized protein LOC659345 [Tribolium castaneum]>gi|270006630|gb|EFA03078.1| hypothetical protein TcasGA2_TC010952 [Tribolium castaneum] -- -- -- -- -- K05724 FGD5_6 FYVE, RhoGEF and PH domain containing 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K05724 Q5DU31 206 1.9e-14 Interactor protein for cytohesin exchange factors 1 OS=Mus musculus GN=Ipcef1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18048 BP_3 206.73 1.60 6504 189236995 XP_970755.2 2880 0.0e+00 PREDICTED: uncharacterized protein LOC659345 [Tribolium castaneum]>gi|270006630|gb|EFA03078.1| hypothetical protein TcasGA2_TC010952 [Tribolium castaneum] -- -- -- -- -- K17536 CNKSR2, KSR2 connector enhancer of kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17536 Q8WXI2 492 1.5e-47 Connector enhancer of kinase suppressor of ras 2 OS=Homo sapiens GN=CNKSR2 PE=1 SV=1 PF00536//PF07647//PF00595//PF13180 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG1738 Membrane-associated guanylate kinase-interacting protein/connector enhancer of KSR-like Cluster-8309.18049 BP_3 668.02 5.09 6620 189236995 XP_970755.2 1955 8.7e-216 PREDICTED: uncharacterized protein LOC659345 [Tribolium castaneum]>gi|270006630|gb|EFA03078.1| hypothetical protein TcasGA2_TC010952 [Tribolium castaneum] -- -- -- -- -- K17536 CNKSR2, KSR2 connector enhancer of kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17536 Q9Z1T4 492 1.6e-47 Connector enhancer of kinase suppressor of ras 2 OS=Rattus norvegicus GN=Cnksr2 PE=1 SV=1 PF00536//PF07647//PF00595//PF13180 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG1738 Membrane-associated guanylate kinase-interacting protein/connector enhancer of KSR-like Cluster-8309.18050 BP_3 410.00 6.98 3124 270004355 EFA00803.1 2392 8.7e-267 hypothetical protein TcasGA2_TC003689 [Tribolium castaneum] 573921410 XM_006648234.1 37 3.82442e-07 PREDICTED: Oryza brachyantha protein arginine N-methyltransferase 5-like (LOC102701698), mRNA K02516 PRMT5, HSL7 protein arginine N-methyltransferase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02516 Q5R698 1395 1.5e-152 Protein arginine N-methyltransferase 5 OS=Pongo abelii GN=PRMT5 PE=2 SV=3 PF05185 PRMT5 arginine-N-methyltransferase GO:0006479 protein methylation GO:0008168 methyltransferase activity -- -- KOG0822 Protein kinase inhibitor Cluster-8309.18057 BP_3 203.68 2.83 3760 642933323 XP_008197368.1 1124 1.1e-119 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 627 2.0e-63 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.1806 BP_3 28.42 1.03 1622 478266356 ENN82768.1 508 1.3e-48 hypothetical protein YQE_00864, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18064 BP_3 30.54 0.36 4433 642924926 XP_008194100.1 373 1.6e-32 PREDICTED: low affinity cationic amino acid transporter 2 [Tribolium castaneum]>gi|270008027|gb|EFA04475.1| hypothetical protein TcasGA2_TC014779 [Tribolium castaneum] 642924925 XM_008195878.1 40 1.17045e-08 PREDICTED: Tribolium castaneum low affinity cationic amino acid transporter 2 (LOC100142535), mRNA K13871 SLC7A14 solute carrier family 7 (cationic amino acid transporter), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13871 B3TP03 184 5.5e-12 Cationic amino acid transporter 2 OS=Gallus gallus GN=SLC7A2 PE=2 SV=1 -- -- GO:0003333//GO:0006865 amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.18066 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18068 BP_3 8.00 0.33 1448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1807 BP_3 7.30 1.08 618 642928681 XP_008199734.1 304 2.2e-25 PREDICTED: uncharacterized protein LOC662519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11380 Stealth protein CR2, conserved region 2 -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.18073 BP_3 61.07 0.96 3351 642936911 XP_008194442.1 2689 3.4e-301 PREDICTED: PHD finger protein 14 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4H9 1117 2.7e-120 PHD finger protein 14 OS=Mus musculus GN=Phf14 PE=1 SV=1 PF01017//PF00130//PF00628//PF06156//PF02059 STAT protein, all-alpha domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//Protein of unknown function (DUF972)//Interleukin-3 GO:0008283//GO:0040007//GO:0007165//GO:0035556//GO:0006355//GO:0006955//GO:0006260 cell proliferation//growth//signal transduction//intracellular signal transduction//regulation of transcription, DNA-templated//immune response//DNA replication GO:0005515//GO:0005135//GO:0008083//GO:0003700//GO:0004871 protein binding//interleukin-3 receptor binding//growth factor activity//transcription factor activity, sequence-specific DNA binding//signal transducer activity GO:0005667//GO:0005894//GO:0005576 transcription factor complex//interleukin-3 receptor complex//extracellular region KOG0957 PHD finger protein Cluster-8309.18075 BP_3 46.00 4.19 821 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18077 BP_3 56.00 4.72 863 642922882 XP_008200436.1 230 1.2e-16 PREDICTED: uncharacterized protein LOC103314920 [Tribolium castaneum]>gi|270006559|gb|EFA03007.1| hypothetical protein TcasGA2_TC010430 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16331//PF13949 TolA binding protein trimerisation//ALIX V-shaped domain binding to HIV GO:0070206 protein trimerization GO:0005515 protein binding -- -- -- -- Cluster-8309.18078 BP_3 47.04 2.86 1085 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18079 BP_3 0.61 2.61 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18080 BP_3 5.00 0.42 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18081 BP_3 21.00 1.12 1196 531445261 AGT57839.1 176 3.0e-10 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14777 Cilia BBSome complex subunit 10 GO:0042384 cilium assembly -- -- GO:0034464 BBSome -- -- Cluster-8309.18083 BP_3 40.00 2.99 937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18086 BP_3 135.00 2.33 3087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18090 BP_3 57.88 5.20 828 91092366 XP_971881.1 287 2.8e-23 PREDICTED: DNA polymerase epsilon subunit 4 [Tribolium castaneum]>gi|270015716|gb|EFA12164.1| hypothetical protein TcasGA2_TC002314 [Tribolium castaneum] -- -- -- -- -- K03506 POLE4 DNA polymerase epsilon subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03506 Q9NR33 189 2.7e-13 DNA polymerase epsilon subunit 4 OS=Homo sapiens GN=POLE4 PE=1 SV=2 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1658 DNA polymerase epsilon, subunit C Cluster-8309.18096 BP_3 1.00 0.48 391 752871781 XP_011253103.1 534 3.0e-52 PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus]>gi|752871783|ref|XP_011253104.1| PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus] 807017284 XM_012305000.1 92 1.18263e-38 PREDICTED: Ceratitis capitata RING finger protein 157 (LOC101463274), mRNA -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.18099 BP_3 208.72 0.78 13230 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 81 5.67061e-31 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q924T7 884 1.1e-92 E3 ubiquitin-protein ligase RNF31 OS=Mus musculus GN=Rnf31 PE=1 SV=2 PF00096//PF05495//PF13806//PF07776//PF13465//PF05121//PF01426//PF07975//PF09182//PF13912//PF00412//PF00641//PF08273//PF02845 Zinc finger, C2H2 type//CHY zinc finger//Rieske-like [2Fe-2S] domain//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Gas vesicle protein K//BAH domain//TFIIH C1-like domain//Bacterial purine repressor, N-terminal//C2H2-type zinc finger//LIM domain//Zn-finger in Ran binding protein and others//Zinc-binding domain of primase-helicase//CUE domain GO:0006807//GO:0042128//GO:0006351//GO:0055114//GO:0006269//GO:0006355//GO:0006281//GO:0031412 nitrogen compound metabolic process//nitrate assimilation//transcription, DNA-templated//oxidation-reduction process//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//DNA repair//gas vesicle organization GO:0046872//GO:0005515//GO:0003677//GO:0004386//GO:0003682//GO:0008942//GO:0008270//GO:0003896 metal ion binding//protein binding//DNA binding//helicase activity//chromatin binding//nitrite reductase [NAD(P)H] activity//zinc ion binding//DNA primase activity GO:0005657//GO:0000785//GO:0005634//GO:0005730 replication fork//chromatin//nucleus//nucleolus -- -- Cluster-8309.181 BP_3 18.00 0.99 1172 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18101 BP_3 226.00 7.78 1692 642912979 XP_008201336.1 1347 7.0e-146 PREDICTED: leucine carboxyl methyltransferase 1 [Tribolium castaneum]>gi|270001907|gb|EEZ98354.1| hypothetical protein TcasGA2_TC000811 [Tribolium castaneum] -- -- -- -- -- K18203 LCMT1 http://www.genome.jp/dbget-bin/www_bget?ko:K18203 Q6P4Z6 721 1.1e-74 Leucine carboxyl methyltransferase 1 OS=Rattus norvegicus GN=Lcmt1 PE=2 SV=1 PF04072//PF03764 Leucine carboxyl methyltransferase//Elongation factor G, domain IV GO:0032259 methylation GO:0008168//GO:0005525 methyltransferase activity//GTP binding -- -- KOG2918 Carboxymethyl transferase Cluster-8309.18102 BP_3 172.87 2.29 3923 270004772 EFA01220.1 4623 0.0e+00 hypothetical protein TcasGA2_TC010547 [Tribolium castaneum] 665794026 XM_008546468.1 291 3.05267e-148 PREDICTED: Microplitis demolitor unconventional myosin-IXb (LOC103569255), transcript variant X2, mRNA K16677 DACHS dachs http://www.genome.jp/dbget-bin/www_bget?ko:K16677 O43795 598 4.8e-60 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF06414//PF00063//PF00612 Zeta toxin//Myosin head (motor domain)//IQ calmodulin-binding motif -- -- GO:0005515//GO:0005524//GO:0003774//GO:0016301 protein binding//ATP binding//motor activity//kinase activity GO:0016459 myosin complex KOG0160 Myosin class V heavy chain Cluster-8309.18105 BP_3 32.00 1.04 1778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18109 BP_3 21.35 2.14 772 642920718 XP_008192534.1 265 9.4e-21 PREDICTED: LYR motif-containing protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXA0 209 1.2e-15 LYR motif-containing protein 5 OS=Taeniopygia guttata GN=LYRM5 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18112 BP_3 43.13 1.00 2366 282392019 NP_001164153.1 156 1.3e-07 fibroblast growth factor 8 precursor [Tribolium castaneum]>gi|270002739|gb|EEZ99186.1| fibroblast growth factor 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18114 BP_3 15.90 1.33 870 642934510 XP_008197694.1 285 5.1e-23 PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|642934512|ref|XP_008197695.1| PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|270013512|gb|EFA09960.1| hypothetical protein TcasGA2_TC012117 [Tribolium castaneum] 642934511 XM_008199473.1 115 4.52278e-51 PREDICTED: Tribolium castaneum AP-1 complex subunit gamma-1 (LOC100142537), transcript variant X3, mRNA K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 165 1.7e-10 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF02883 Adaptin C-terminal domain GO:0015031//GO:0016192//GO:0006886 protein transport//vesicle-mediated transport//intracellular protein transport GO:0008565 protein transporter activity GO:0044431//GO:0030131 Golgi apparatus part//clathrin adaptor complex -- -- Cluster-8309.18115 BP_3 22.28 0.46 2652 91091956 XP_968337.1 3352 0.0e+00 PREDICTED: exocyst complex component 6 [Tribolium castaneum]>gi|270000776|gb|EEZ97223.1| hypothetical protein TcasGA2_TC011021 [Tribolium castaneum] 571522972 XM_393572.5 71 4.07692e-26 PREDICTED: Apis mellifera exocyst complex component 6 (sec15), transcript variant 2, mRNA -- -- -- -- Q9VDE6 1919 2.1e-213 Exocyst complex component 6 OS=Drosophila melanogaster GN=sec15 PE=1 SV=1 PF01207//PF04091//PF04048 Dihydrouridine synthase (Dus)//Exocyst complex subunit Sec15-like//Sec8 exocyst complex component specific domain GO:0008033//GO:0015031//GO:0055114//GO:0006904 tRNA processing//protein transport//oxidation-reduction process//vesicle docking involved in exocytosis GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity GO:0000145 exocyst KOG2176 Exocyst complex, subunit SEC15 Cluster-8309.18116 BP_3 20.96 0.53 2197 657580152 XP_008294028.1 187 3.0e-11 PREDICTED: histone-lysine N-methyltransferase SETMAR-like isoform X1 [Stegastes partitus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18118 BP_3 14.70 1.24 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18121 BP_3 121.41 1.25 4961 646723340 KDR23974.1 697 4.9e-70 Stathmin [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q09002 147 1.2e-07 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF00836//PF02096//PF01956//PF08074//PF14372//PF01442//PF01544//PF00318//PF13741//PF06667//PF08496 Stathmin family//60Kd inner membrane protein//Integral membrane protein DUF106//CHDCT2 (NUC038) domain//Domain of unknown function (DUF4413)//Apolipoprotein A1/A4/E domain//CorA-like Mg2+ transporter protein//Ribosomal protein S2//Mitochondrial ribosomal protein S25//Phage shock protein B//Peptidase family S49 N-terminal GO:0042254//GO:0006355//GO:0031110//GO:0051205//GO:0055085//GO:0009271//GO:0006869//GO:0006412//GO:0030001//GO:0042157 ribosome biogenesis//regulation of transcription, DNA-templated//regulation of microtubule polymerization or depolymerization//protein insertion into membrane//transmembrane transport//phage shock//lipid transport//translation//metal ion transport//lipoprotein metabolic process GO:0016818//GO:0004252//GO:0008270//GO:0003735//GO:0005524//GO:0046873//GO:0008289//GO:0003677 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//serine-type endopeptidase activity//zinc ion binding//structural constituent of ribosome//ATP binding//metal ion transmembrane transporter activity//lipid binding//DNA binding GO:0005840//GO:0005622//GO:0016021//GO:0005576//GO:0016020//GO:0005634//GO:0005886//GO:0005763 ribosome//intracellular//integral component of membrane//extracellular region//membrane//nucleus//plasma membrane//mitochondrial small ribosomal subunit -- -- Cluster-8309.18126 BP_3 274.55 6.56 2310 478250251 ENN70751.1 828 1.5e-85 hypothetical protein YQE_12540, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AZB8 223 8.5e-17 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF01609//PF04827//PF09057 Transposase DDE domain//Plant transposon protein//Second Mitochondria-derived Activator of Caspases GO:0006919//GO:0006915//GO:0006313 activation of cysteine-type endopeptidase activity involved in apoptotic process//apoptotic process//transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity GO:0005739 mitochondrion -- -- Cluster-8309.18127 BP_3 10.51 0.43 1473 795014016 XP_011883734.1 545 6.1e-53 PREDICTED: putative nuclease HARBI1 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity -- -- -- -- Cluster-8309.1813 BP_3 1.00 2.28 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05680//PF03938 ATP synthase E chain//Outer membrane protein (OmpH-like) GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0051082//GO:0015078 unfolded protein binding//hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.18130 BP_3 28.92 0.43 3501 751233342 XP_011170346.1 680 3.2e-68 PREDICTED: zinc finger MYM-type protein 1-like, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- Q5SVZ6 200 6.0e-14 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18133 BP_3 26.90 0.34 4066 478261830 ENN80953.1 694 8.9e-70 hypothetical protein YQE_02658, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4KM51 143 2.8e-07 Transcription elongation factor, mitochondrial OS=Rattus norvegicus GN=Tefm PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18135 BP_3 102.00 8.15 895 642938132 XP_008199779.1 554 3.3e-54 PREDICTED: glycine cleavage system H protein, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K02437 gcvH, GCSH glycine cleavage system H protein http://www.genome.jp/dbget-bin/www_bget?ko:K02437 Q9U616 471 5.8e-46 Glycine cleavage system H protein, mitochondrial OS=Drosophila melanogaster GN=ppl PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3373 Glycine cleavage system H protein (lipoate-binding) Cluster-8309.18137 BP_3 54.95 0.79 3651 270002093 EEZ98540.1 2276 2.9e-253 hypothetical protein TcasGA2_TC001044 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P90980 150 3.9e-08 Protein kinase C-like 2 OS=Caenorhabditis elegans GN=pkc-2 PE=2 SV=2 PF00168//PF13180//PF00595 C2 domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0696 Serine/threonine protein kinase Cluster-8309.18138 BP_3 151.42 2.53 3178 642915323 XP_008190571.1 2812 0.0e+00 PREDICTED: valine--tRNA ligase [Tribolium castaneum]>gi|270003973|gb|EFA00421.1| hypothetical protein TcasGA2_TC003272 [Tribolium castaneum] 470518689 XM_004353314.1 56 1.06672e-17 Acanthamoeba castellanii str. Neff valine-tRNA ligase (ACA1_300880) mRNA, complete cds K01873 VARS, valS valyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01873 Q5ST30 1875 3.2e-208 Valine--tRNA ligase, mitochondrial OS=Homo sapiens GN=VARS2 PE=1 SV=2 PF04905//PF09334//PF00133//PF08264//PF13603 NAB conserved region 2 (NCD2)//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA//Leucyl-tRNA synthetase, Domain 2 GO:0006418//GO:0045892//GO:0006412 tRNA aminoacylation for protein translation//negative regulation of transcription, DNA-templated//translation GO:0000166//GO:0004812//GO:0002161//GO:0005524//GO:0016874 nucleotide binding//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity//ATP binding//ligase activity GO:0005634 nucleus KOG0432 Valyl-tRNA synthetase Cluster-8309.1814 BP_3 4.00 0.31 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18140 BP_3 97.00 3.69 1559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18141 BP_3 2.00 2.06 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18142 BP_3 491.99 8.34 3135 91080171 XP_970238.1 4040 0.0e+00 PREDICTED: transportin-3 [Tribolium castaneum] 658920433 XM_008401725.1 75 2.8842e-28 PREDICTED: Poecilia reticulata transportin 3 (tnpo3), mRNA K15436 TRPO3, MTR10 transportin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K15436 Q6P2B1 2264 2.5e-253 Transportin-3 OS=Mus musculus GN=Tnpo3 PE=1 SV=1 PF03810//PF00452//PF05823 Importin-beta N-terminal domain//Apoptosis regulator proteins, Bcl-2 family//Nematode fatty acid retinoid binding protein (Gp-FAR-1) GO:0042981//GO:0006886 regulation of apoptotic process//intracellular protein transport GO:0008536//GO:0008289 Ran GTPase binding//lipid binding -- -- KOG2081 Nuclear transport regulator Cluster-8309.18143 BP_3 50.15 0.52 4943 642911263 XP_008199814.1 2052 3.7e-227 PREDICTED: small G protein signaling modulator 3 homolog isoform X1 [Tribolium castaneum]>gi|642911265|ref|XP_008199821.1| PREDICTED: small G protein signaling modulator 3 homolog isoform X1 [Tribolium castaneum] 820846062 XM_012485562.1 179 7.02003e-86 PREDICTED: Apis florea small G protein signaling modulator 3 homolog (LOC100867963), mRNA -- -- -- -- A6H8I2 1331 6.1e-145 Small G protein signaling modulator 3 homolog OS=Xenopus laevis GN=sgsm3 PE=2 SV=1 PF12202//PF00400//PF04494 Oxidative-stress-responsive kinase 1 C terminal//WD domain, G-beta repeat//WD40 associated region in TFIID subunit, NTD2 domain GO:0006355//GO:0016310//GO:0009069 regulation of transcription, DNA-templated//phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0005515 ATP binding//protein serine/threonine kinase activity//protein binding GO:0005634 nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.18144 BP_3 166.39 19.60 701 642925206 XP_008194468.1 638 4.8e-64 PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum]>gi|642925208|ref|XP_008194469.1| PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum] -- -- -- -- -- K15153 MED31, SOH1 mediator of RNA polymerase II transcription subunit 31 http://www.genome.jp/dbget-bin/www_bget?ko:K15153 Q8IH24 483 1.8e-47 Mediator of RNA polymerase II transcription subunit 31 OS=Drosophila melanogaster GN=MED31 PE=1 SV=2 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4086 Transcriptional regulator SOH1 Cluster-8309.1815 BP_3 4.00 0.51 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18152 BP_3 3.00 1.22 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18153 BP_3 18.45 0.82 1378 270006030 EFA02478.1 561 7.9e-55 hypothetical protein TcasGA2_TC008169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K5B3 205 6.2e-15 Multiple coagulation factor deficiency protein 2 homolog OS=Rattus norvegicus GN=Mcfd2 PE=2 SV=1 PF13499//PF00036//PF13833//PF13405 EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG4065 Uncharacterized conserved protein Cluster-8309.18157 BP_3 8.36 0.53 1055 478261318 ENN80734.1 416 4.0e-38 hypothetical protein YQE_02842, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BZ36 251 2.2e-20 RAD50-interacting protein 1 OS=Mus musculus GN=Rint1 PE=2 SV=2 PF04437//PF03572 RINT-1 / TIP-1 family//Peptidase family S41 GO:0048193//GO:0006508 Golgi vesicle transport//proteolysis GO:0008236 serine-type peptidase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.18158 BP_3 169.03 4.95 1937 478261514 ENN80859.1 705 2.2e-71 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 P13582 474 5.6e-46 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.18163 BP_3 232.49 2.36 5045 642935053 XP_008199922.1 1091 1.0e-115 PREDICTED: cerebellar degeneration-related protein 2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 347 7.8e-31 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF01025//PF02183//PF10473//PF16326//PF06156//PF04977//PF07926 GrpE//Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//ABC transporter C-terminal domain//Protein of unknown function (DUF972)//Septum formation initiator//TPR/MLP1/MLP2-like protein GO:0006260//GO:0006355//GO:0006606//GO:0007049//GO:0006457 DNA replication//regulation of transcription, DNA-templated//protein import into nucleus//cell cycle//protein folding GO:0000774//GO:0051087//GO:0042803//GO:0043565//GO:0003700//GO:0003677//GO:0045502//GO:0008134 adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//dynein binding//transcription factor binding GO:0030286//GO:0005667 dynein complex//transcription factor complex -- -- Cluster-8309.18165 BP_3 509.58 26.32 1225 91082925 XP_972790.1 599 2.8e-59 PREDICTED: mitochondrial import inner membrane translocase subunit Tim21 [Tribolium castaneum]>gi|270007057|gb|EFA03505.1| hypothetical protein TcasGA2_TC013506 [Tribolium castaneum] -- -- -- -- -- K17796 TIM21 mitochondrial import inner membrane translocase subunit TIM21 http://www.genome.jp/dbget-bin/www_bget?ko:K17796 Q3SZV6 346 2.5e-31 Mitochondrial import inner membrane translocase subunit Tim21 OS=Bos taurus GN=TIMM21 PE=2 SV=1 PF08294 TIM21 GO:0030150 protein import into mitochondrial matrix -- -- GO:0005744 mitochondrial inner membrane presequence translocase complex KOG4836 Uncharacterized conserved protein Cluster-8309.18168 BP_3 133.00 3.78 1988 546682221 ERL92182.1 951 6.9e-100 hypothetical protein D910_09502 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZJA9 316 1.2e-27 Loss of heterozygosity 12 chromosomal region 1 protein homolog OS=Gallus gallus GN=LOH12CR1 PE=2 SV=1 PF04420//PF02601//PF16276 CHD5-like protein//Exonuclease VII, large subunit//Nucleophosmin C-terminal domain GO:0071816//GO:0006308 tail-anchored membrane protein insertion into ER membrane//DNA catabolic process GO:0003676//GO:0008855 nucleic acid binding//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.18176 BP_3 52.02 1.77 1706 642922712 XP_008193292.1 145 1.7e-06 PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922714|ref|XP_008193293.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922716|ref|XP_008193294.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922718|ref|XP_008193295.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18185 BP_3 178.43 2.53 3695 642936336 XP_008198400.1 1993 1.9e-220 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1246 3.3e-135 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF00570//PF00196//PF09382//PF00270//PF06480//PF04851 HRDC domain//Bacterial regulatory proteins, luxR family//RQC domain//DEAD/DEAH box helicase//FtsH Extracellular//Type III restriction enzyme, res subunit GO:0006355//GO:0006260//GO:0006281 regulation of transcription, DNA-templated//DNA replication//DNA repair GO:0008270//GO:0003676//GO:0043140//GO:0004222//GO:0005524//GO:0016787//GO:0003677 zinc ion binding//nucleic acid binding//ATP-dependent 3'-5' DNA helicase activity//metalloendopeptidase activity//ATP binding//hydrolase activity//DNA binding GO:0005622//GO:0005657//GO:0016021 intracellular//replication fork//integral component of membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.18186 BP_3 320.07 4.60 3642 642936336 XP_008198400.1 2020 1.4e-223 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1274 1.8e-138 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF06480//PF04851//PF00270//PF00196//PF00570//PF09382 FtsH Extracellular//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Bacterial regulatory proteins, luxR family//HRDC domain//RQC domain GO:0006355//GO:0006260//GO:0006281 regulation of transcription, DNA-templated//DNA replication//DNA repair GO:0043140//GO:0008270//GO:0003676//GO:0005524//GO:0004222//GO:0003677//GO:0016787 ATP-dependent 3'-5' DNA helicase activity//zinc ion binding//nucleic acid binding//ATP binding//metalloendopeptidase activity//DNA binding//hydrolase activity GO:0005622//GO:0016021//GO:0005657 intracellular//integral component of membrane//replication fork KOG0351 ATP-dependent DNA helicase Cluster-8309.1819 BP_3 1.00 0.36 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18190 BP_3 110.08 1.56 3692 642936336 XP_008198400.1 1997 6.5e-221 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1257 1.7e-136 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF04851//PF06480//PF00570//PF00196//PF09382//PF00270 Type III restriction enzyme, res subunit//FtsH Extracellular//HRDC domain//Bacterial regulatory proteins, luxR family//RQC domain//DEAD/DEAH box helicase GO:0006355//GO:0006260//GO:0006281 regulation of transcription, DNA-templated//DNA replication//DNA repair GO:0008270//GO:0003676//GO:0043140//GO:0004222//GO:0005524//GO:0003677//GO:0016787 zinc ion binding//nucleic acid binding//ATP-dependent 3'-5' DNA helicase activity//metalloendopeptidase activity//ATP binding//DNA binding//hydrolase activity GO:0005622//GO:0005657//GO:0016021 intracellular//replication fork//integral component of membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.18192 BP_3 23.00 4.83 521 506965393 AGM32087.1 564 1.3e-55 40S ribosomal protein S10 [Coptotermes formosanus] -- -- -- -- -- K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 P63326 545 8.8e-55 40S ribosomal protein S10 OS=Rattus norvegicus GN=Rps10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3344 40s ribosomal protein s10 Cluster-8309.18194 BP_3 17.08 0.47 2027 270001817 EEZ98264.1 1387 1.9e-150 hypothetical protein TcasGA2_TC000706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.3e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18196 BP_3 7.00 0.34 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18199 BP_3 2.24 0.72 442 549438545 AGX25161.1 160 8.0e-09 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.182 BP_3 2.00 0.37 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1820 BP_3 7.05 0.62 837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18201 BP_3 176.35 2.54 3639 549438545 AGX25161.1 2415 2.2e-269 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 1472 2.0e-161 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF02129//PF00930//PF03583//PF01738//PF00326 X-Pro dipeptidyl-peptidase (S15 family)//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Secretory lipase//Dienelactone hydrolase family//Prolyl oligopeptidase family GO:0046486//GO:0006508//GO:0016042 glycerolipid metabolic process//proteolysis//lipid catabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.18203 BP_3 74.46 2.61 1665 642919261 XP_008191798.1 1255 3.2e-135 PREDICTED: glucosamine-6-phosphate isomerase isoform X2 [Tribolium castaneum] 195473851 XM_002089170.1 181 1.80324e-87 Drosophila yakuba GE25482 (Dyak\GE25482), partial mRNA K02564 nagB, GNPDA glucosamine-6-phosphate deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K02564 Q16HW7 1169 1.2e-126 Glucosamine-6-phosphate isomerase OS=Aedes aegypti GN=Gnpda1 PE=3 SV=1 PF01182//PF11975 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase//Family 4 glycosyl hydrolase C-terminal domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG3148 Glucosamine-6-phosphate isomerase Cluster-8309.18207 BP_3 37.70 1.00 2112 642933386 XP_008197395.1 1021 5.6e-108 PREDICTED: HEAT repeat-containing protein 2 [Tribolium castaneum]>gi|270011379|gb|EFA07827.1| hypothetical protein TcasGA2_TC005396 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q86Y56 377 1.1e-34 Dynein assembly factor 5, axonemal OS=Homo sapiens GN=DNAAF5 PE=1 SV=4 PF00440//PF11640//PF02985 Bacterial regulatory proteins, tetR family//Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0003677//GO:0004674//GO:0005515 DNA binding//protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.1821 BP_3 6.95 0.59 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18211 BP_3 54.00 0.46 5903 795018288 XP_011859156.1 2928 0.0e+00 PREDICTED: uncharacterized protein K02A2.6-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- P0CT41 925 8.7e-98 Transposon Tf2-12 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-12 PE=3 SV=1 PF17068//PF05087//PF13683//PF02035//PF00665//PF00098 Required for respiratory growth protein 8 mitochondrial//Rotavirus VP2 protein//Integrase core domain//Coagulin//Integrase core domain//Zinc knuckle GO:0042381//GO:0015074//GO:0000002 hemolymph coagulation//DNA integration//mitochondrial genome maintenance GO:0003723//GO:0008270//GO:0003676 RNA binding//zinc ion binding//nucleic acid binding GO:0005576//GO:0019013 extracellular region//viral nucleocapsid -- -- Cluster-8309.18214 BP_3 39.76 0.71 2999 91083749 XP_971342.1 2169 6.0e-241 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 1088 5.5e-117 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18216 BP_3 113.75 2.98 2130 91079170 XP_967650.1 875 4.8e-91 PREDICTED: viral IAP-associated factor homolog [Tribolium castaneum]>gi|270004241|gb|EFA00689.1| hypothetical protein TcasGA2_TC003566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MR62 659 2.2e-67 Viral IAP-associated factor homolog OS=Drosophila melanogaster GN=viaf PE=1 SV=1 PF00445//PF01528//PF04104 Ribonuclease T2 family//Herpesvirus glycoprotein M//Eukaryotic and archaeal DNA primase, large subunit GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896//GO:0003723//GO:0033897 DNA primase activity//RNA binding//ribonuclease T2 activity GO:0005657//GO:0016020//GO:0005730 replication fork//membrane//nucleolus KOG3170 Conserved phosducin-like protein Cluster-8309.18217 BP_3 10.03 1.16 708 751458989 XP_011184187.1 158 2.2e-08 PREDICTED: F-box/SPRY domain-containing protein 1 [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- B3MDR0 153 3.4e-09 F-box/SPRY domain-containing protein 1 OS=Drosophila ananassae GN=Fsn PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.1822 BP_3 6.00 2.71 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.18225 BP_3 76.44 1.56 2648 546684608 ERL94225.1 1617 5.4e-177 hypothetical protein D910_11506 [Dendroctonus ponderosae] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q7ZX21 712 1.9e-73 OTU domain-containing protein 5-A OS=Xenopus laevis GN=otud5-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.18227 BP_3 5.91 0.32 1187 642927939 XP_008195454.1 173 6.7e-10 PREDICTED: uncharacterized protein LOC103313590 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18230 BP_3 3.00 0.59 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18233 BP_3 43.00 3.25 929 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18234 BP_3 7.00 0.43 1071 795090478 XP_011879350.1 572 3.3e-56 PREDICTED: RNA-binding protein 5-like [Vollenhovia emeryi] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 Q91YE7 182 2.2e-12 RNA-binding protein 5 OS=Mus musculus GN=Rbm5 PE=1 SV=1 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.18236 BP_3 20.00 0.59 1916 13273161 AAK17768.1 2073 5.2e-230 cytochrome c oxidase subunit I [Homo sapiens]>gi|32892928|gb|AAP89610.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892942|gb|AAP89623.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892956|gb|AAP89636.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892970|gb|AAP89649.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892984|gb|AAP89662.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|69065316|gb|AAZ03038.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072717|emb|CAJ98078.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|111072731|emb|CAJ98091.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072745|emb|CAJ98104.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072759|emb|CAJ98117.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072773|emb|CAJ98130.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072787|emb|CAJ98143.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072801|emb|CAJ98156.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|170664840|gb|ACB28990.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|171453140|dbj|BAG15084.1| cytochrome oxydase subunit I [Homo sapiens]>gi|171453602|dbj|BAG15513.1| cytochrome oxydase subunit I [Homo sapiens]>gi|189179033|dbj|BAG38865.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|292596803|gb|ADE33275.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|292596873|gb|ADE33340.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|305657132|gb|ADM60881.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|359471014|gb|AEV50453.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|363902165|gb|AEW43561.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|375071522|gb|AFA33462.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381221049|gb|AFF63986.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381228987|gb|AFF71357.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381232263|gb|AFF74399.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381233957|gb|AFF75972.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381234083|gb|AFF76089.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381235427|gb|AFF77337.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381244597|gb|AFF85852.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381246641|gb|AFF87750.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381248923|gb|AFF89869.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381249455|gb|AFF90363.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381250477|gb|AFF91312.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381254705|gb|AFF95238.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381256917|gb|AFF97292.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381258261|gb|AFF98540.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381259549|gb|AFF99736.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381264406|gb|AFG04247.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381264616|gb|AFG04442.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381274192|gb|AFG13334.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381276250|gb|AFG15245.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|396579972|gb|AFN86827.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|396579986|gb|AFN86840.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|396580000|gb|AFN86853.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397179351|gb|AFO24189.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397181157|gb|AFO25866.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397181731|gb|AFO26399.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397182697|gb|AFO27296.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397187051|gb|AFO31339.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397187121|gb|AFO31404.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397188465|gb|AFO32652.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397188857|gb|AFO33016.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397192399|gb|AFO36305.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397193155|gb|AFO37007.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|401783337|gb|AFQ05215.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|410062024|gb|AFV54302.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|443540395|gb|AEH03913.2| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|481044970|gb|AGJ95267.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|525316009|gb|AGR43553.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|525316513|gb|AGR44021.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|525316527|gb|AGR44034.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|530848180|gb|AGT54285.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|530848278|gb|AGT54376.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545749835|gb|AGW54088.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545750283|gb|AGW54504.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545758710|gb|AGW62329.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545767516|gb|AGW70506.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545767670|gb|AGW70649.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545768048|gb|AGW71000.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774082|gb|AGW76603.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774110|gb|AGW76629.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774124|gb|AGW76642.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774404|gb|AGW76902.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545775706|gb|AGW78111.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545776406|gb|AGW78761.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545776882|gb|AGW79203.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545778016|gb|AGW80256.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|552099765|gb|AGY46043.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|556712696|gb|AGZ76177.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|570436927|gb|AHE78967.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|606232060|gb|AHW38074.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|614528043|gb|AHX53206.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|656331059|gb|AID08560.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|700279764|gb|AIU60764.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|700281038|gb|AIU61947.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|753364022|gb|AJI44293.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|768802593|gb|AJV87742.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens] 893712435 KT277303.1 1916 0 Homo sapiens haplogroup I4a mitochondrion, complete genome K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00395 2061 5.3e-230 Cytochrome c oxidase subunit 1 OS=Homo sapiens GN=MT-CO1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.18237 BP_3 54.75 1.75 1797 385199936 AFI45016.1 1376 3.2e-149 cytochrome P450 CYP4BD4v1 [Dendroctonus ponderosae] 826411405 XM_012687282.1 45 7.79569e-12 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105840370), partial mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VL92 956 6.7e-102 Cytochrome P450 4e3 OS=Drosophila melanogaster GN=Cyp4e3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.18238 BP_3 17.07 0.52 1866 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06337 DUSP domain GO:0006508//GO:0016579 proteolysis//protein deubiquitination GO:0004843 ubiquitin-specific protease activity -- -- -- -- Cluster-8309.18239 BP_3 32.17 1.00 1846 766928720 XP_011496419.1 298 3.3e-24 PREDICTED: dihydrofolate reductase [Ceratosolen solmsi marchali] 389612312 AK403254.1 35 2.90226e-06 Papilio xuthus mRNA for dihydrofolate reductase, partial cds, sequence id: Px-1353, expressed in epidermis K00287 folA dihydrofolate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00287 P04753 229 1.4e-17 Dihydrofolate reductase OS=Mesocricetus auratus GN=DHFR PE=2 SV=4 PF00186 Dihydrofolate reductase GO:0006761//GO:0006545//GO:0055114//GO:0009165//GO:0046656 dihydrofolate biosynthetic process//glycine biosynthetic process//oxidation-reduction process//nucleotide biosynthetic process//folic acid biosynthetic process GO:0004146 dihydrofolate reductase activity -- -- KOG1324 Dihydrofolate reductase Cluster-8309.18240 BP_3 7.00 0.72 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18241 BP_3 120.00 1.92 3304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18242 BP_3 14.00 1.80 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18243 BP_3 527.75 16.07 1875 189240381 XP_001815436.1 708 9.7e-72 PREDICTED: uncharacterized protein LOC100142429 [Tribolium castaneum]>gi|270011479|gb|EFA07927.1| hypothetical protein TcasGA2_TC005505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05041 Pecanex protein (C-terminus) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.18246 BP_3 14.22 0.33 2345 189235966 XP_969617.2 364 9.4e-32 PREDICTED: zinc finger CCCH domain-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CHP0 202 2.4e-14 Zinc finger CCCH domain-containing protein 3 OS=Mus musculus GN=Zc3h3 PE=2 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- KOG1492 C3H1-type Zn-finger protein Cluster-8309.18247 BP_3 23.66 0.67 1988 189235966 XP_969617.2 802 1.3e-82 PREDICTED: zinc finger CCCH domain-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IXZ2 320 4.2e-28 Zinc finger CCCH domain-containing protein 3 OS=Homo sapiens GN=ZC3H3 PE=1 SV=3 PF00642//PF01468 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//GA module GO:0009405 pathogenesis GO:0046872 metal ion binding -- -- KOG1492 C3H1-type Zn-finger protein Cluster-8309.18248 BP_3 19.00 0.98 1224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1825 BP_3 1.00 0.34 434 664777237 XP_008507911.1 603 3.4e-60 PREDICTED: 60S ribosomal protein L30-like [Equus przewalskii] 324021697 NM_000989.3 434 0 Homo sapiens ribosomal protein L30 (RPL30), mRNA K02908 RP-L30e, RPL30 large subunit ribosomal protein L30e http://www.genome.jp/dbget-bin/www_bget?ko:K02908 P62890 587 9.9e-60 60S ribosomal protein L30 OS=Rattus norvegicus GN=Rpl30 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2988 60S ribosomal protein L30 Cluster-8309.18251 BP_3 23.38 0.98 1446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18252 BP_3 59.00 6.33 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18253 BP_3 13.21 1.01 925 478260834 ENN80486.1 312 4.0e-26 hypothetical protein YQE_03090, partial [Dendroctonus ponderosae] -- -- -- -- -- K05666 ABCC2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05666 Q63120 198 2.7e-14 Canalicular multispecific organic anion transporter 1 OS=Rattus norvegicus GN=Abcc2 PE=2 SV=1 PF17001 Type III secretion basal body protein I, YscI, HrpB, PscI GO:0009306 protein secretion -- -- -- -- KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.18255 BP_3 10.95 1.57 628 478259443 ENN79333.1 141 1.8e-06 hypothetical protein YQE_04242, partial [Dendroctonus ponderosae]>gi|546675184|gb|ERL86420.1| hypothetical protein D910_03827 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18256 BP_3 16.00 1.01 1057 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13724 DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.1826 BP_3 36.00 4.70 661 546681292 ERL91406.1 208 3.3e-14 hypothetical protein D910_08738 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18263 BP_3 24.60 0.85 1692 189239355 XP_974286.2 2019 8.4e-224 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 1597 3.0e-176 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 PF00622//PF00270//PF04851 SPRY domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003676//GO:0016787//GO:0003677//GO:0008026//GO:0005515 ATP binding//nucleic acid binding//hydrolase activity//DNA binding//ATP-dependent helicase activity//protein binding -- -- KOG0349 Putative DEAD-box RNA helicase DDX1 Cluster-8309.18265 BP_3 54.42 2.28 1440 189239355 XP_974286.2 1156 8.4e-124 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 955 7.0e-102 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 -- -- -- -- GO:0008026//GO:0005524//GO:0003676 ATP-dependent helicase activity//ATP binding//nucleic acid binding -- -- KOG0349 Putative DEAD-box RNA helicase DDX1 Cluster-8309.18268 BP_3 303.96 8.29 2060 332374200 AEE62241.1 1094 1.9e-116 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17569 GPATCH2 G patch domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17569 -- -- -- -- PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.18269 BP_3 2.00 0.33 586 332374200 AEE62241.1 165 2.8e-09 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18273 BP_3 113.00 4.20 1589 642935206 XP_008199690.1 1226 7.1e-132 PREDICTED: deoxynucleotidyltransferase terminal-interacting protein 1 [Tribolium castaneum]>gi|270014206|gb|EFA10654.1| hypothetical protein TcasGA2_TC016291 [Tribolium castaneum] -- -- -- -- -- K08707 DNTTIP1 deoxynucleotidyltransferase terminal-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08707 Q9H147 458 3.3e-44 Deoxynucleotidyltransferase terminal-interacting protein 1 OS=Homo sapiens GN=DNTTIP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4801 Member of the steroid/thyroid receptor superfamily Cluster-8309.18277 BP_3 5.24 0.56 742 478253481 ENN73808.1 812 3.4e-84 hypothetical protein YQE_09586, partial [Dendroctonus ponderosae]>gi|546679135|gb|ERL89640.1| hypothetical protein D910_07005 [Dendroctonus ponderosae] -- -- -- -- -- K13280 SEC11, sipW signal peptidase, endoplasmic reticulum-type http://www.genome.jp/dbget-bin/www_bget?ko:K13280 Q9BY50 694 6.7e-72 Signal peptidase complex catalytic subunit SEC11C OS=Homo sapiens GN=SEC11C PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3342 Signal peptidase I Cluster-8309.1828 BP_3 3.00 3.30 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18281 BP_3 26.81 1.69 1057 91092480 XP_967611.1 1090 2.8e-116 PREDICTED: probable dynactin subunit 2 [Tribolium castaneum]>gi|270012933|gb|EFA09381.1| hypothetical protein TcasGA2_TC001942 [Tribolium castaneum] -- -- -- -- -- K10424 DCTN2 dynactin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10424 Q1HQF2 591 8.3e-60 Probable dynactin subunit 2 OS=Aedes aegypti GN=Dmn PE=2 SV=2 PF03449//PF16519//PF04513//PF15724//PF02244//PF02346 Transcription elongation factor, N-terminal//Tetramerisation domain of TRPM//Baculovirus polyhedron envelope protein, PEP, C terminus//TMEM119 family//Carboxypeptidase activation peptide//Chordopoxvirus multifunctional envelope protein A27 GO:0019064//GO:0032784//GO:0001503//GO:0051262//GO:0006508//GO:0007017 fusion of virus membrane with host plasma membrane//regulation of DNA-templated transcription, elongation//ossification//protein tetramerization//proteolysis//microtubule-based process GO:0005198//GO:0004180//GO:0003677 structural molecule activity//carboxypeptidase activity//DNA binding GO:0019031//GO:0019028//GO:0005869 viral envelope//viral capsid//dynactin complex -- -- Cluster-8309.18286 BP_3 35.30 0.63 3005 189235393 XP_001810875.1 424 1.3e-38 PREDICTED: targeting protein for Xklp2 [Tribolium castaneum]>gi|270003583|gb|EFA00031.1| hypothetical protein TcasGA2_TC002838 [Tribolium castaneum] -- -- -- -- -- K16812 TPX2 targeting protein for Xklp2 http://www.genome.jp/dbget-bin/www_bget?ko:K16812 E2RYF8 258 9.7e-21 Targeting protein for Xklp2 homolog OS=Patiria pectinifera GN=TPX2 PE=2 SV=1 PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.18287 BP_3 10.55 2.57 489 478259929 ENN79731.1 340 1.2e-29 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 191 9.3e-14 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.18290 BP_3 24.29 0.56 2386 72094941 XP_798033.1 651 5.0e-65 PREDICTED: protein SpAN [Strongylocentrotus purpuratus] -- -- -- -- -- K08606 MEP1B meprin B http://www.genome.jp/dbget-bin/www_bget?ko:K08606 P42674 597 3.8e-60 Blastula protease 10 OS=Paracentrotus lividus GN=BP10 PE=2 SV=1 PF00413//PF01400 Matrixin//Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3714 Meprin A metalloprotease Cluster-8309.18292 BP_3 34.59 0.79 2406 72094941 XP_798033.1 801 2.1e-82 PREDICTED: protein SpAN [Strongylocentrotus purpuratus] -- -- -- -- -- K08076 E3.4.24.21 astacin http://www.genome.jp/dbget-bin/www_bget?ko:K08076 P42674 722 1.2e-74 Blastula protease 10 OS=Paracentrotus lividus GN=BP10 PE=2 SV=1 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3714 Meprin A metalloprotease Cluster-8309.18295 BP_3 9.00 0.46 1231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18296 BP_3 63.70 0.74 4455 557015008 XP_006007989.1 729 8.5e-74 PREDICTED: zinc finger protein 91-like [Latimeria chalumnae] 795495644 XM_011710948.1 39 4.23076e-08 PREDICTED: Macaca nemestrina zinc finger protein 713 (ZNF713), transcript variant X5, mRNA K09230 SCAN SCAN domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09230 P10077 678 2.9e-69 Zinc finger protein 27 OS=Mus musculus GN=Zfp27 PE=2 SV=2 PF07975//PF02178//PF06689//PF13465//PF08054//PF16622//PF05191//PF01428//PF13912//PF00130//PF00096//PF07776 TFIIH C1-like domain//AT hook motif//ClpX C4-type zinc finger//Zinc-finger double domain//Leucine operon leader peptide//zinc-finger C2H2-type//Adenylate kinase, active site lid//AN1-like Zinc finger//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0035556//GO:0006144//GO:0046034//GO:0006281//GO:0009098 intracellular signal transduction//purine nucleobase metabolic process//ATP metabolic process//DNA repair//leucine biosynthetic process GO:0004017//GO:0046872//GO:0008270//GO:0046983//GO:0003677 adenylate kinase activity//metal ion binding//zinc ion binding//protein dimerization activity//DNA binding GO:0005634 nucleus -- -- Cluster-8309.18297 BP_3 77.32 0.91 4381 821385245 XP_012386849.1 708 2.3e-71 PREDICTED: zinc finger protein 850-like [Orcinus orca] 795495644 XM_011710948.1 39 4.15991e-08 PREDICTED: Macaca nemestrina zinc finger protein 713 (ZNF713), transcript variant X5, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ECI4 679 2.2e-69 Zinc finger protein 470 OS=Homo sapiens GN=ZNF470 PE=2 SV=3 PF07776//PF13912//PF02892//PF02178//PF13465//PF00096//PF08054 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//BED zinc finger//AT hook motif//Zinc-finger double domain//Zinc finger, C2H2 type//Leucine operon leader peptide GO:0009098 leucine biosynthetic process GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.183 BP_3 29.34 0.37 4115 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1830 BP_3 17.69 1.22 991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18300 BP_3 47.09 1.26 2099 646717950 KDR20605.1 2060 1.8e-228 Elongator complex protein 3 [Zootermopsis nevadensis] 766940529 XM_011504565.1 405 0 PREDICTED: Ceratosolen solmsi marchali probable elongator complex protein 3 (LOC105366209), transcript variant X1, mRNA K07739 ELP3, KAT9 elongator complex protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07739 Q9VQZ6 2010 4.7e-224 Probable elongator complex protein 3 OS=Drosophila melanogaster GN=Elp3 PE=2 SV=1 PF04055 Radical SAM superfamily -- -- GO:0051536//GO:0003824 iron-sulfur cluster binding//catalytic activity -- -- KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase Cluster-8309.18303 BP_3 14.40 0.43 1920 91079462 XP_966980.1 401 4.0e-36 PREDICTED: uncharacterized protein LOC655346 [Tribolium castaneum]>gi|270003455|gb|EEZ99902.1| hypothetical protein TcasGA2_TC002686 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18304 BP_3 30.36 0.80 2132 123227460 CAM27169.1 257 2.2e-19 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] 564252665 XM_006265293.1 115 1.13413e-50 PREDICTED: Alligator mississippiensis Sp5 transcription factor (SP5), mRNA K09197 SP7 transcription factor Sp7 http://www.genome.jp/dbget-bin/www_bget?ko:K09197 Q8VI67 551 7.3e-55 Transcription factor Sp7 OS=Mus musculus GN=Sp7 PE=1 SV=1 PF04625//PF15761//PF00096//PF13465//PF13912 DEC-1 protein, N-terminal region//Immortalisation up-regulated protein//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger GO:0007304 chorion-containing eggshell formation GO:0005213//GO:0046872 structural constituent of chorion//metal ion binding GO:0005576//GO:0005634//GO:0042600 extracellular region//nucleus//chorion -- -- Cluster-8309.18306 BP_3 94.85 0.82 5883 270009029 EFA05477.1 800 6.6e-82 hypothetical protein TcasGA2_TC015661 [Tribolium castaneum] 301172737 NR_036276.1 51 1.19471e-14 Tribolium castaneum microRNA let-7 (Mirlet7), microRNA K10606 FANCL, PHF9 E3 ubiquitin-protein ligase FANCL http://www.genome.jp/dbget-bin/www_bget?ko:K10606 Q9NW38 346 1.2e-30 E3 ubiquitin-protein ligase FANCL OS=Homo sapiens GN=FANCL PE=1 SV=2 PF13639//PF07163//PF12906//PF12678//PF00628//PF12861 Ring finger domain//Pex26 protein//RING-variant domain//RING-H2 zinc finger//PHD-finger//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567//GO:0045046 protein ubiquitination//protein import into peroxisome membrane GO:0032403//GO:0005515//GO:0004842//GO:0008270 protein complex binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680//GO:0005779 anaphase-promoting complex//integral component of peroxisomal membrane -- -- Cluster-8309.18308 BP_3 345.01 8.60 2226 642920057 XP_008192187.1 1719 6.8e-189 PREDICTED: mitochondrial import inner membrane translocase subunit TIM44 [Tribolium castaneum] -- -- -- -- -- K17804 TIM44 mitochondrial import inner membrane translocase subunit TIM44 http://www.genome.jp/dbget-bin/www_bget?ko:K17804 O43615 1032 1.3e-110 Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens GN=TIMM44 PE=1 SV=2 PF08336//PF07464//PF05478//PF07926//PF02932 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Apolipophorin-III precursor (apoLp-III)//Prominin//TPR/MLP1/MLP2-like protein//Neurotransmitter-gated ion-channel transmembrane region GO:0006606//GO:0055114//GO:0006811//GO:0006525//GO:0018401//GO:0006869//GO:0006560 protein import into nucleus//oxidation-reduction process//ion transport//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//lipid transport//proline metabolic process GO:0008289//GO:0004656//GO:0016702 lipid binding//procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005576//GO:0016020//GO:0016021//GO:0005783 extracellular region//membrane//integral component of membrane//endoplasmic reticulum KOG2580 Mitochondrial import inner membrane translocase, subunit TIM44 Cluster-8309.18310 BP_3 158.29 11.28 968 91084301 XP_971859.1 879 7.4e-92 PREDICTED: structure-specific endonuclease subunit slx1 [Tribolium castaneum]>gi|270008803|gb|EFA05251.1| hypothetical protein TcasGA2_TC015403 [Tribolium castaneum] -- -- -- -- -- K15078 SLX1 structure-specific endonuclease subunit SLX1 http://www.genome.jp/dbget-bin/www_bget?ko:K15078 Q0IH86 728 9.9e-76 Structure-specific endonuclease subunit slx1 OS=Xenopus laevis GN=slx1a PE=2 SV=1 PF03119//PF00628 NAD-dependent DNA ligase C4 zinc finger domain//PHD-finger GO:0006281//GO:0006260 DNA repair//DNA replication GO:0005515//GO:0003911 protein binding//DNA ligase (NAD+) activity -- -- KOG3005 GIY-YIG type nuclease Cluster-8309.18315 BP_3 2957.98 95.03 1792 642937193 XP_008198733.1 1396 1.6e-151 PREDICTED: LOW QUALITY PROTEIN: catalase-like [Tribolium castaneum] -- -- -- -- -- K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 1140 3.1e-123 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 PF00199 Catalase GO:0006979//GO:0006804//GO:0055114//GO:0006568//GO:0015947 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process//tryptophan metabolic process//methane metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-8309.18316 BP_3 2350.02 78.21 1740 642937193 XP_008198733.1 1886 2.3e-208 PREDICTED: LOW QUALITY PROTEIN: catalase-like [Tribolium castaneum] -- -- -- -- -- K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P00432 1476 3.3e-162 Catalase OS=Bos taurus GN=CAT PE=1 SV=3 PF00199 Catalase GO:0006979//GO:0006804//GO:0055114//GO:0006568//GO:0015947 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process//tryptophan metabolic process//methane metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-8309.18319 BP_3 10.42 0.53 1240 642927012 XP_008195103.1 312 5.3e-26 PREDICTED: RNA polymerase II-associated protein 3 [Tribolium castaneum]>gi|270010040|gb|EFA06488.1| hypothetical protein TcasGA2_TC009385 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28IV3 150 1.3e-08 RNA polymerase II-associated protein 3 OS=Xenopus tropicalis GN=rpap3 PE=2 SV=1 PF01024//PF06003//PF00435//PF09726//PF02840//PF11365 Colicin pore forming domain//Survival motor neuron protein (SMN)//Spectrin repeat//Transmembrane protein//Prp18 domain//Protein of unknown function (DUF3166) GO:0050829//GO:0019835//GO:0010506//GO:0006397//GO:0008380 defense response to Gram-negative bacterium//cytolysis//regulation of autophagy//mRNA processing//RNA splicing GO:0003723//GO:0005515 RNA binding//protein binding GO:0005634//GO:0016021//GO:0005681//GO:0005615//GO:0005737 nucleus//integral component of membrane//spliceosomal complex//extracellular space//cytoplasm KOG4648 Uncharacterized conserved protein, contains LRR repeats Cluster-8309.1832 BP_3 12.00 1.92 593 207298841 ACI23572.1 335 5.5e-29 cardiac muscle actin [Homarus americanus] 3907621 AF100987.1 132 1.07242e-60 AF100987 Penaeus monodon actin 2 (act2) mRNA, complete cds K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 O16808 325 3.3e-29 Actin OS=Mayetiola destructor PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.18325 BP_3 7.91 0.89 720 546672740 ERL84510.1 159 1.7e-08 hypothetical protein D910_01940 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18328 BP_3 6.00 0.55 820 795271913 XP_011857417.1 1341 1.7e-145 PREDICTED: 40S ribosomal protein S3 isoform X1 [Mandrillus leucophaeus] 378548188 NM_001005.4 820 0 Homo sapiens ribosomal protein S3 (RPS3), transcript variant 1, mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 Q0Z8U2 1240 3.6e-135 40S ribosomal protein S3 OS=Sus scrofa GN=RPS3 PE=1 SV=1 PF07650 KH domain -- -- GO:0003723 RNA binding -- -- KOG3181 40S ribosomal protein S3 Cluster-8309.18329 BP_3 702.00 32.03 1348 642914825 XP_008194954.1 764 2.2e-78 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q5XGE9 446 6.9e-43 Lipase member H OS=Xenopus tropicalis GN=liph PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1833 BP_3 59.68 1.30 2501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18331 BP_3 4.34 0.39 829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18334 BP_3 4.73 0.32 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18335 BP_3 63.35 1.66 2128 91081457 XP_974014.1 838 9.3e-87 PREDICTED: probable cytochrome P450 301a1, mitochondrial [Tribolium castaneum]>gi|270006458|gb|EFA02906.1| cytochrome P450 301A1 [Tribolium castaneum] 642920930 XM_968921.2 99 8.87531e-42 PREDICTED: Tribolium castaneum cytochrome P450 301A1 (LOC662845), mRNA -- -- -- -- Q9V6D6 721 1.4e-74 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0004497//GO:0020037//GO:0005506//GO:0009055//GO:0016705 monooxygenase activity//heme binding//iron ion binding//electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.18337 BP_3 645.95 5.27 6196 478257502 ENN77658.1 2721 1.2e-304 hypothetical protein YQE_05952, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q13439 325 3.4e-28 Golgin subfamily A member 4 OS=Homo sapiens GN=GOLGA4 PE=1 SV=1 PF13851//PF01465 Growth-arrest specific micro-tubule binding//GRIP domain GO:0048870//GO:0000042 cell motility//protein targeting to Golgi GO:0005515 protein binding GO:0031514 motile cilium -- -- Cluster-8309.1834 BP_3 27.32 0.59 2533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18340 BP_3 31.00 1.26 1480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18341 BP_3 33.00 8.05 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18342 BP_3 69.79 1.17 3170 642933276 XP_008197354.1 542 2.9e-52 PREDICTED: cell wall protein RBR3 isoform X1 [Tribolium castaneum] 817211936 XM_012426709.1 59 2.28694e-19 PREDICTED: Orussus abietinus uncharacterized LOC105700657 (LOC105700657), mRNA -- -- -- -- Q96NU1 194 2.7e-13 Sterile alpha motif domain-containing protein 11 OS=Homo sapiens GN=SAMD11 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18345 BP_3 87.57 0.79 5666 642928360 XP_972133.2 2245 1.8e-249 PREDICTED: ATP-binding cassette sub-family B member 8, mitochondrial isoform X1 [Tribolium castaneum] 768408887 XM_011551471.1 79 3.1313e-30 PREDICTED: Plutella xylostella igLON family member 5-like (LOC105381682), mRNA K05655 ABCB8 ATP-binding cassette, subfamily B (MDR/TAP), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K05655 B2GUP8 1544 1.4e-169 ATP-binding cassette sub-family B member 8, mitochondrial OS=Xenopus tropicalis GN=abcb8 PE=2 SV=1 PF06414//PF00005//PF03193//PF13895//PF00664//PF13304//PF01583//PF12814//PF06472 Zeta toxin//ABC transporter//Protein of unknown function, DUF258//Immunoglobulin domain//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Adenylylsulphate kinase//Meiotic cell cortex C-terminal pleckstrin homology//ABC transporter transmembrane region 2 GO:0006810//GO:0055085//GO:0006144//GO:0000103//GO:0032065 transport//transmembrane transport//purine nucleobase metabolic process//sulfate assimilation//cortical protein anchoring GO:0042626//GO:0016887//GO:0016301//GO:0003924//GO:0005524//GO:0005525//GO:0005543//GO:0004020//GO:0005515 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTPase activity//ATP binding//GTP binding//phospholipid binding//adenylylsulfate kinase activity//protein binding GO:0005938//GO:0016021 cell cortex//integral component of membrane KOG0058 Peptide exporter, ABC superfamily Cluster-8309.18347 BP_3 19.00 5.70 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18348 BP_3 1379.05 13.28 5297 642930197 XP_008196297.1 6176 0.0e+00 PREDICTED: protein jagged-1b isoform X2 [Tribolium castaneum] 642930196 XM_008198075.1 758 0 PREDICTED: Tribolium castaneum protein jagged-1b (LOC652942), transcript variant X2, mRNA K06052 JAGGED jagged http://www.genome.jp/dbget-bin/www_bget?ko:K06052 Q90Y54 2958 0.0e+00 Protein jagged-1b OS=Danio rerio GN=jag1b PE=2 SV=1 PF07657//PF01414//PF00008//PF07645 N terminus of Notch ligand//Delta serrate ligand//EGF-like domain//Calcium-binding EGF domain GO:0007154//GO:0007219//GO:0007275 cell communication//Notch signaling pathway//multicellular organismal development GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.1835 BP_3 17.09 2.25 658 668466452 KFB53409.1 356 2.2e-31 AGAP004572-PA-like protein [Anopheles sinensis] 642913709 XM_008202908.1 105 1.22279e-45 PREDICTED: Tribolium castaneum acyl-CoA desaturase 1 (LOC662865), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O00767 300 2.9e-26 Acyl-CoA desaturase OS=Homo sapiens GN=SCD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1600 Fatty acid desaturase Cluster-8309.18351 BP_3 30.00 2.10 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18352 BP_3 11.00 3.84 429 91078472 XP_968116.1 163 3.5e-09 PREDICTED: probable helicase with zinc finger domain [Tribolium castaneum]>gi|270003858|gb|EFA00306.1| hypothetical protein TcasGA2_TC003141 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414//PF13174//PF02025//PF13181//PF00515 TPR repeat//Tetratricopeptide repeat//Interleukin 5//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0005137//GO:0008083//GO:0005515 interleukin-5 receptor binding//growth factor activity//protein binding GO:0005576//GO:0005895 extracellular region//interleukin-5 receptor complex -- -- Cluster-8309.18353 BP_3 433.00 4.86 4583 546677353 ERL88210.1 4130 0.0e+00 hypothetical protein D910_05598, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DFV5 2628 2.3e-295 Probable helicase with zinc finger domain OS=Mus musculus GN=Helz PE=1 SV=2 PF01006//PF08405//PF08043//PF00580//PF01637//PF02562//PF00642//PF04851 Hepatitis C virus non-structural protein NS4a//Viral polyprotein N-terminal//Xin repeat//UvrD/REP helicase N-terminal domain//Archaeal ATPase//PhoH-like protein//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Type III restriction enzyme, res subunit GO:0030036//GO:0006144//GO:0016032//GO:0044419//GO:0006508 actin cytoskeleton organization//purine nucleobase metabolic process//viral process//interspecies interaction between organisms//proteolysis GO:0003779//GO:0016787//GO:0005524//GO:0003677//GO:0017111//GO:0046872//GO:0004197//GO:0003968 actin binding//hydrolase activity//ATP binding//DNA binding//nucleoside-triphosphatase activity//metal ion binding//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0019012//GO:0031379//GO:0030054 virion//RNA-directed RNA polymerase complex//cell junction KOG1804 RNA helicase Cluster-8309.18354 BP_3 6.14 0.34 1172 642923797 XP_008193887.1 184 3.5e-11 PREDICTED: uncharacterized protein LOC663689 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18355 BP_3 1162.53 15.95 3805 546683413 ERL93229.1 4000 0.0e+00 hypothetical protein D910_10525 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BYA0 2403 2.3e-269 Tubulin-specific chaperone D OS=Mus musculus GN=Tbcd PE=2 SV=1 PF08429//PF02985 PLU-1-like protein//HEAT repeat GO:0055114 oxidation-reduction process GO:0005515//GO:0016706 protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- KOG1943 Beta-tubulin folding cofactor D Cluster-8309.18357 BP_3 2.00 0.35 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18359 BP_3 10.00 4.91 388 478256535 ENN76719.1 363 2.0e-32 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 545833013 XM_005664905.1 45 1.57163e-12 PREDICTED: Sus scrofa zinc finger protein 71 (ZNF71), transcript variant X4, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q14591 303 7.6e-27 Zinc finger protein 271 OS=Homo sapiens GN=ZNF271 PE=2 SV=4 PF00518//PF06467//PF00096//PF02892//PF00412//PF13912//PF01428//PF16622//PF05191//PF13465//PF07975 Early Protein (E6)//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C2H2 type//BED zinc finger//LIM domain//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc-finger double domain//TFIIH C1-like domain GO:0006281//GO:0006144//GO:0046034 DNA repair//purine nucleobase metabolic process//ATP metabolic process GO:0004017//GO:0046872//GO:0008270//GO:0003677 adenylate kinase activity//metal ion binding//zinc ion binding//DNA binding GO:0042025 host cell nucleus -- -- Cluster-8309.18360 BP_3 66.00 3.05 1336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.18361 BP_3 109.16 1.99 2935 576249490 AHH29251.1 2700 1.6e-302 Inebriated-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 2069 9.6e-231 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF01384//PF00209 Phosphate transporter family//Sodium:neurotransmitter symporter family GO:0006812//GO:0006836//GO:0006817 cation transport//neurotransmitter transport//phosphate ion transport GO:0005315//GO:0005328 inorganic phosphate transmembrane transporter activity//neurotransmitter:sodium symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.18365 BP_3 12.00 0.43 1648 270003130 EEZ99577.1 227 5.1e-16 hypothetical protein TcasGA2_TC001563 [Tribolium castaneum] 642915759 XM_962024.2 53 2.54864e-16 PREDICTED: Tribolium castaneum transmembrane 9 superfamily member 3 (LOC655481), mRNA K17087 TM9SF3 transmembrane 9 superfamily member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17087 Q9HD45 216 4.0e-16 Transmembrane 9 superfamily member 3 OS=Homo sapiens GN=TM9SF3 PE=1 SV=2 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1277 Endosomal membrane proteins, EMP70 Cluster-8309.18367 BP_3 15.00 1.87 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18372 BP_3 403.29 15.41 1553 478263661 ENN81967.1 435 3.7e-40 hypothetical protein YQE_01678, partial [Dendroctonus ponderosae]>gi|546676699|gb|ERL87655.1| hypothetical protein D910_05046 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6NWC9 181 4.3e-12 G kinase-anchoring protein 1 OS=Danio rerio GN=gkap1 PE=2 SV=1 PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-8309.18373 BP_3 62.35 0.64 4967 642922135 XP_008193031.1 2247 9.0e-250 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.1e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF00755//PF04699 Choline/Carnitine o-acyltransferase//ARP2/3 complex 16 kDa subunit (p16-Arc) GO:0034314//GO:0030833 Arp2/3 complex-mediated actin nucleation//regulation of actin filament polymerization GO:0016746 transferase activity, transferring acyl groups GO:0015629//GO:0005885 actin cytoskeleton//Arp2/3 protein complex KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.18375 BP_3 79.71 0.81 5018 642922135 XP_008193031.1 2247 9.1e-250 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.1e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF04699//PF00755 ARP2/3 complex 16 kDa subunit (p16-Arc)//Choline/Carnitine o-acyltransferase GO:0034314//GO:0030833 Arp2/3 complex-mediated actin nucleation//regulation of actin filament polymerization GO:0016746 transferase activity, transferring acyl groups GO:0005885//GO:0015629 Arp2/3 protein complex//actin cytoskeleton KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.18376 BP_3 750.48 7.89 4878 642922135 XP_008193031.1 2247 8.8e-250 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.0e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF00755//PF04699 Choline/Carnitine o-acyltransferase//ARP2/3 complex 16 kDa subunit (p16-Arc) GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation GO:0016746 transferase activity, transferring acyl groups GO:0005885//GO:0015629 Arp2/3 protein complex//actin cytoskeleton KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.18377 BP_3 906.72 9.36 4960 642922135 XP_008193031.1 2240 5.8e-249 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.1e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF04699//PF00755 ARP2/3 complex 16 kDa subunit (p16-Arc)//Choline/Carnitine o-acyltransferase GO:0034314//GO:0030833 Arp2/3 complex-mediated actin nucleation//regulation of actin filament polymerization GO:0016746 transferase activity, transferring acyl groups GO:0015629//GO:0005885 actin cytoskeleton//Arp2/3 protein complex KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.18378 BP_3 1023.56 10.72 4892 642922135 XP_008193031.1 2247 8.9e-250 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.0e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF00755//PF04699 Choline/Carnitine o-acyltransferase//ARP2/3 complex 16 kDa subunit (p16-Arc) GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation GO:0016746 transferase activity, transferring acyl groups GO:0015629//GO:0005885 actin cytoskeleton//Arp2/3 protein complex KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.18381 BP_3 13.61 0.84 1072 327292006 XP_003230711.1 384 2.1e-34 PREDICTED: gastrula zinc finger protein XlCGF57.1-like [Anolis carolinensis] -- -- -- -- -- -- -- -- -- P51522 373 1.6e-34 Zinc finger protein 83 OS=Homo sapiens GN=ZNF83 PE=2 SV=3 PF13912//PF01428//PF13465//PF00096 C2H2-type zinc finger//AN1-like Zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.18382 BP_3 107.83 1.50 3762 642919490 XP_008191893.1 2826 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum]>gi|642919492|ref|XP_008191894.1| PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18384 BP_3 206.95 1.49 6991 808134936 XP_012169902.1 3552 0.0e+00 PREDICTED: uncharacterized protein LOC100648762 [Bombus terrestris] 805759873 XM_012297744.1 247 1.57264e-123 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 2.9e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF14604//PF00018//PF00621 Variant SH3 domain//SH3 domain//RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- -- -- Cluster-8309.18385 BP_3 6.77 0.64 800 546677206 ERL88085.1 201 2.6e-13 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18386 BP_3 7.00 0.72 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18391 BP_3 11.35 0.76 1013 642939160 XP_969591.2 559 1.0e-54 PREDICTED: protein D3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 444 8.9e-43 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.18395 BP_3 9.71 6.25 363 270003816 EFA00264.1 188 3.7e-12 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01853//PF05225 MOZ/SAS family//helix-turn-helix, Psq domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0016747 DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.18397 BP_3 96.00 29.34 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18398 BP_3 9.27 0.31 1737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18400 BP_3 428.81 12.90 1894 820805536 AKG92759.1 682 1.0e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 2.89606e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 5.0e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF00010//PF01586 Helix-loop-helix DNA-binding domain//Myogenic Basic domain GO:0006355//GO:0007517 regulation of transcription, DNA-templated//muscle organ development GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.18403 BP_3 193.01 17.92 811 642912538 XP_008200905.1 453 1.6e-42 PREDICTED: uncharacterized protein LOC103315037 [Tribolium castaneum]>gi|270002598|gb|EEZ99045.1| hypothetical protein TcasGA2_TC004919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18406 BP_3 406.00 10.56 2145 91082329 XP_974627.1 763 4.7e-78 PREDICTED: mannose-P-dolichol utilization defect 1 protein homolog [Tribolium castaneum]>gi|270007185|gb|EFA03633.1| hypothetical protein TcasGA2_TC013726 [Tribolium castaneum] -- -- -- -- -- K09660 MPDU1 mannose-P-dolichol utilization defect 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09660 Q9VMW8 627 1.1e-63 Mannose-P-dolichol utilization defect 1 protein homolog OS=Drosophila melanogaster GN=CG3792 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.18409 BP_3 527.11 13.24 2211 91086103 XP_967597.1 2529 8.0e-283 PREDICTED: actin-related protein 5 [Tribolium castaneum]>gi|270009896|gb|EFA06344.1| hypothetical protein TcasGA2_TC009219 [Tribolium castaneum] 462365391 APGK01027627.1 62 3.41397e-21 Dendroctonus ponderosae Seq01027637, whole genome shotgun sequence K11672 ACTR5, ARP5, INO80M actin-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11672 Q17GZ9 1557 1.7e-171 Actin-related protein 5 OS=Aedes aegypti GN=Arp5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0681 Actin-related protein - Arp5p Cluster-8309.18410 BP_3 20.89 0.51 2272 91086103 XP_967597.1 2399 9.7e-268 PREDICTED: actin-related protein 5 [Tribolium castaneum]>gi|270009896|gb|EFA06344.1| hypothetical protein TcasGA2_TC009219 [Tribolium castaneum] -- -- -- -- -- K11672 ACTR5, ARP5, INO80M actin-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11672 Q17GZ9 1506 1.4e-165 Actin-related protein 5 OS=Aedes aegypti GN=Arp5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0681 Actin-related protein - Arp5p Cluster-8309.18411 BP_3 213.00 7.95 1583 332372598 AEE61441.1 1173 9.9e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZU82 423 3.8e-40 Golgin subfamily A member 5 OS=Rattus norvegicus GN=Golga5 PE=1 SV=1 PF15898 cGMP-dependent protein kinase interacting domain -- -- GO:0019901 protein kinase binding -- -- KOG4677 Golgi integral membrane protein Cluster-8309.18413 BP_3 1.61 0.40 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18415 BP_3 43.10 3.43 897 642912276 XP_008200634.1 634 1.8e-63 PREDICTED: exportin-7 isoform X2 [Tribolium castaneum]>gi|270002549|gb|EEZ98996.1| hypothetical protein TcasGA2_TC004857 [Tribolium castaneum] -- -- -- -- -- K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q569Z2 452 9.3e-44 Exportin-7-B OS=Xenopus laevis GN=xpo7-b PE=2 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008565//GO:0008536 protein transporter activity//Ran GTPase binding GO:0005643 nuclear pore KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.18417 BP_3 170.99 3.17 2894 270008674 EFA05122.1 2413 3.0e-269 hypothetical protein TcasGA2_TC015236 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 1015 1.6e-108 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF01691//PF07533//PF00916//PF03083//PF01566 Adenovirus E1B 19K protein / small t-antigen//BRK domain//Sulfate permease family//Sugar efflux transporter for intercellular exchange//Natural resistance-associated macrophage protein GO:0008272//GO:0043066//GO:0006810 sulfate transport//negative regulation of apoptotic process//transport GO:0005521//GO:0016817//GO:0015116//GO:0005215//GO:0005515 lamin binding//hydrolase activity, acting on acid anhydrides//sulfate transmembrane transporter activity//transporter activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.18419 BP_3 844.55 15.98 2839 270008674 EFA05122.1 2410 6.5e-269 hypothetical protein TcasGA2_TC015236 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 1020 4.0e-109 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF01691//PF01566//PF03083//PF00916 Adenovirus E1B 19K protein / small t-antigen//Natural resistance-associated macrophage protein//Sugar efflux transporter for intercellular exchange//Sulfate permease family GO:0043066//GO:0006810//GO:0008272 negative regulation of apoptotic process//transport//sulfate transport GO:0005521//GO:0005215//GO:0015116 lamin binding//transporter activity//sulfate transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.1842 BP_3 128.17 4.85 1565 270004813 EFA01261.1 524 1.8e-50 cytochrome P450 303A1 [Tribolium castaneum] -- -- -- -- -- K07418 CYP2J cytochrome P450, family 2, subfamily J http://www.genome.jp/dbget-bin/www_bget?ko:K07418 Q9V399 324 1.1e-28 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.18422 BP_3 245.70 2.44 5149 642933323 XP_008197368.1 1156 3.0e-123 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 668 4.8e-68 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.18423 BP_3 716.37 86.26 692 91084789 XP_972673.1 588 2.9e-58 PREDICTED: 6-pyruvoyl tetrahydrobiopterin synthase [Tribolium castaneum]>gi|270008955|gb|EFA05403.1| hypothetical protein TcasGA2_TC015575 [Tribolium castaneum] -- -- -- -- -- K01737 queD, ptpS, PTS 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01737 P48611 436 5.1e-42 6-pyruvoyl tetrahydrobiopterin synthase OS=Drosophila melanogaster GN=pr PE=1 SV=1 -- -- GO:0046656//GO:0006729 folic acid biosynthetic process//tetrahydrobiopterin biosynthetic process GO:0003874//GO:0046872 6-pyruvoyltetrahydropterin synthase activity//metal ion binding -- -- KOG4105 6-pyruvoyl tetrahydrobiopterin synthase Cluster-8309.18425 BP_3 526.96 7.73 3578 91095075 XP_972860.1 3860 0.0e+00 PREDICTED: small G protein signaling modulator 3 homolog isoform X2 [Tribolium castaneum]>gi|270014751|gb|EFA11199.1| hypothetical protein TcasGA2_TC005163 [Tribolium castaneum] 820846062 XM_012485562.1 519 0 PREDICTED: Apis florea small G protein signaling modulator 3 homolog (LOC100867963), mRNA -- -- -- -- A6H8I2 2747 2.8e-309 Small G protein signaling modulator 3 homolog OS=Xenopus laevis GN=sgsm3 PE=2 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding GO:0005622 intracellular KOG2058 Ypt/Rab GTPase activating protein Cluster-8309.18428 BP_3 164.21 1.64 5116 642911263 XP_008199814.1 2052 3.8e-227 PREDICTED: small G protein signaling modulator 3 homolog isoform X1 [Tribolium castaneum]>gi|642911265|ref|XP_008199821.1| PREDICTED: small G protein signaling modulator 3 homolog isoform X1 [Tribolium castaneum] 820846062 XM_012485562.1 179 7.26753e-86 PREDICTED: Apis florea small G protein signaling modulator 3 homolog (LOC100867963), mRNA -- -- -- -- A6H8I2 1331 6.3e-145 Small G protein signaling modulator 3 homolog OS=Xenopus laevis GN=sgsm3 PE=2 SV=1 PF04494//PF00400 WD40 associated region in TFIID subunit, NTD2 domain//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.1843 BP_3 69.65 1.94 2018 642917922 XP_008200616.1 1299 3.1e-140 PREDICTED: probable cytochrome P450 303a1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V399 860 1.0e-90 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.18430 BP_3 1.00 0.90 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18431 BP_3 124.82 2.03 3249 91077726 XP_975075.1 2486 1.1e-277 PREDICTED: protein inturned [Tribolium castaneum]>gi|270002215|gb|EEZ98662.1| hypothetical protein TcasGA2_TC001193 [Tribolium castaneum] 642914358 XM_969982.2 79 1.78701e-30 PREDICTED: Tribolium castaneum protein inturned (LOC663956), mRNA -- -- -- -- F6U5F9 822 4.2e-86 Protein inturned OS=Xenopus tropicalis GN=intu PE=3 SV=1 PF03276//PF15281 Spumavirus gag protein//Consortin C-terminus GO:0046718//GO:0042998//GO:0075521//GO:0019076 viral entry into host cell//positive regulation of Golgi to plasma membrane protein transport//microtubule-dependent intracellular transport of viral material towards nucleus//viral release from host cell GO:0071253 connexin binding GO:0019028//GO:0042025//GO:0005802//GO:0044163//GO:0030430 viral capsid//host cell nucleus//trans-Golgi network//host cytoskeleton//host cell cytoplasm -- -- Cluster-8309.18434 BP_3 46.79 1.77 1566 642931629 XP_008196662.1 965 1.3e-101 PREDICTED: broad-complex core protein isoform 6-like isoform X4 [Tribolium castaneum] -- -- -- -- -- K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P42282 347 2.4e-31 Protein tramtrack, alpha isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=3 PF13912//PF02892//PF00651//PF00096//PF13465 C2H2-type zinc finger//BED zinc finger//BTB/POZ domain//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.18435 BP_3 14.00 1.60 713 82795519 ABB91673.1 400 1.9e-36 arthrodial cuticle protein AMP9.3 [Callinectes sapidus] 82795518 DQ288148.1 336 5.15046e-174 Callinectes sapidus arthrodial cuticle protein AMP9.3 mRNA, complete cds -- -- -- -- P81388 205 3.2e-15 Cuticle protein AMP4 OS=Homarus americanus PE=1 SV=1 PF02048//PF00379 Heat-stable enterotoxin ST//Insect cuticle protein GO:0009405 pathogenesis GO:0042302 structural constituent of cuticle GO:0005576 extracellular region -- -- Cluster-8309.18437 BP_3 149.39 1.35 5609 642938156 XP_969509.2 657 2.4e-65 PREDICTED: cleavage and polyadenylation specificity factor subunit 5 [Tribolium castaneum] 696970323 XM_009557133.1 59 4.06672e-19 PREDICTED: Cuculus canorus nudix (nucleoside diphosphate linked moiety X)-type motif 21 (NUDT21), mRNA K14397 NUDT21, CPSF5, CFIM25 cleavage and polyadenylation specificity factor subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K14397 Q7T3C6 466 1.4e-44 Cleavage and polyadenylation specificity factor subunit 5 OS=Danio rerio GN=cpsf5 PE=2 SV=1 PF00293//PF13869 NUDIX domain//Nucleotide hydrolase GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729 hydrolase activity//mRNA binding GO:0005849 mRNA cleavage factor complex KOG1689 mRNA cleavage factor I subunit Cluster-8309.18439 BP_3 667.52 28.69 1413 642938156 XP_969509.2 1206 1.3e-129 PREDICTED: cleavage and polyadenylation specificity factor subunit 5 [Tribolium castaneum] 696970323 XM_009557133.1 122 9.57269e-55 PREDICTED: Cuculus canorus nudix (nucleoside diphosphate linked moiety X)-type motif 21 (NUDT21), mRNA K14397 NUDT21, CPSF5, CFIM25 cleavage and polyadenylation specificity factor subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K14397 Q7T3C6 943 1.7e-100 Cleavage and polyadenylation specificity factor subunit 5 OS=Danio rerio GN=cpsf5 PE=2 SV=1 PF00293//PF13869 NUDIX domain//Nucleotide hydrolase GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729 hydrolase activity//mRNA binding GO:0005849 mRNA cleavage factor complex KOG1689 mRNA cleavage factor I subunit Cluster-8309.18442 BP_3 53.00 1.26 2315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04647 Accessory gene regulator B GO:0009372//GO:0009405 quorum sensing//pathogenesis GO:0008233 peptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.18444 BP_3 3.00 0.59 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18445 BP_3 76.00 1.45 2825 91081769 XP_973294.1 1556 6.8e-170 PREDICTED: leucine-rich repeat-containing protein 24 [Tribolium castaneum]>gi|270006275|gb|EFA02723.1| hypothetical protein TcasGA2_TC008448 [Tribolium castaneum] 642921390 XM_968234.2 171 1.11724e-81 PREDICTED: Tribolium castaneum leucine-rich repeat-containing protein 24 (LOC662117), mRNA -- -- -- -- Q50LG9 330 4.1e-29 Leucine-rich repeat-containing protein 24 OS=Homo sapiens GN=LRRC24 PE=2 SV=2 PF00560//PF13855//PF13895 Leucine Rich Repeat//Leucine rich repeat//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18449 BP_3 10.00 2.04 528 641655859 XP_008179752.1 244 1.7e-18 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.18450 BP_3 1.00 1.20 321 170068163 XP_001868759.1 349 7.0e-31 conserved hypothetical protein [Culex quinquefasciatus]>gi|167864268|gb|EDS27651.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03802 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase GO:0051191 prosthetic group biosynthetic process -- -- -- -- -- -- Cluster-8309.18451 BP_3 15.38 1.05 996 328698759 XP_003240725.1 546 3.1e-53 PREDICTED: serine/arginine repetitive matrix protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18455 BP_3 35.09 1.42 1481 546673719 ERL85275.1 1353 1.2e-146 hypothetical protein D910_02696 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96I51 932 3.4e-99 Williams-Beuren syndrome chromosomal region 16 protein OS=Homo sapiens GN=WBSCR16 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.18458 BP_3 13.00 0.77 1108 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1846 BP_3 12.00 2.53 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18463 BP_3 5.36 0.49 819 91082383 XP_968748.1 231 8.7e-17 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18464 BP_3 287.00 7.60 2111 641672628 XP_008186016.1 253 6.3e-19 PREDICTED: uncharacterized protein LOC100164223 isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q9SDW0 164 5.4e-10 Trihelix transcription factor GT-3a OS=Arabidopsis thaliana GN=GT-3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18465 BP_3 47.31 0.85 2979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18469 BP_3 475.26 10.09 2561 189235703 XP_001807591.1 3233 0.0e+00 PREDICTED: CAS1 domain-containing protein 1 [Tribolium castaneum] 642917634 XM_001807539.2 82 3.02062e-32 PREDICTED: Tribolium castaneum CAS1 domain-containing protein 1 (LOC655926), mRNA -- -- -- -- Q96PB1 1444 2.5e-158 CAS1 domain-containing protein 1 OS=Homo sapiens GN=CASD1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1699 O-acetyltransferase Cluster-8309.1847 BP_3 2.00 0.48 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18475 BP_3 36.26 0.84 2373 270001817 EEZ98264.1 1589 8.6e-174 hypothetical protein TcasGA2_TC000706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32PJ7 167 2.7e-10 Tensin-4 OS=Bos taurus GN=TNS4 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18478 BP_3 68.14 1.26 2893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18479 BP_3 7.00 0.53 928 646702024 KDR11468.1 420 1.2e-38 Sodium-driven chloride bicarbonate exchanger [Zootermopsis nevadensis] -- -- -- -- -- K13861 SLC4A10, NCBE solute carrier family 4 (sodium bicarbonate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13861 Q8BTY2 220 7.6e-17 Sodium bicarbonate cotransporter 3 OS=Mus musculus GN=Slc4a7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.18481 BP_3 3.10 0.58 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF07645//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//Calcium-binding EGF domain//zinc-finger C2H2-type -- -- GO:0046872//GO:0005509 metal ion binding//calcium ion binding -- -- -- -- Cluster-8309.18482 BP_3 76.30 1.36 3002 642919719 XP_008192036.1 433 1.2e-39 PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919721|ref|XP_008192037.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919723|ref|XP_008192039.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|270005423|gb|EFA01871.1| hypothetical protein TcasGA2_TC007476 [Tribolium castaneum] -- -- -- -- -- K17479 GRXCR1 glutaredoxin domain-containing cysteine-rich protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17479 Q9W4S1 183 4.8e-12 Glutaredoxin domain-containing cysteine-rich protein CG12206 OS=Drosophila melanogaster GN=CG12206 PE=2 SV=2 PF03334 Na+/H+ antiporter subunit GO:0015672//GO:0015992 monovalent inorganic cation transport//proton transport GO:0005451 monovalent cation:proton antiporter activity -- -- -- -- Cluster-8309.18483 BP_3 5.00 0.38 924 332373670 AEE61976.1 280 2.0e-22 unknown [Dendroctonus ponderosae]>gi|478257673|gb|ENN77820.1| hypothetical protein YQE_05704, partial [Dendroctonus ponderosae] -- -- -- -- -- K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q9GZP9 239 4.8e-19 Derlin-2 OS=Homo sapiens GN=DERL2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0858 Predicted membrane protein Cluster-8309.18487 BP_3 100.00 1.34 3893 642916498 XP_008191067.1 2136 5.2e-237 PREDICTED: maternal embryonic leucine zipper kinase-like [Tribolium castaneum] -- -- -- -- -- K08799 MELK maternal embryonic leucine zipper kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08799 Q28GW8 1116 4.1e-120 Maternal embryonic leucine zipper kinase OS=Xenopus tropicalis GN=melk PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0583 Serine/threonine protein kinase Cluster-8309.18491 BP_3 8.00 0.40 1256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18492 BP_3 231.00 8.37 1622 642922343 XP_973628.2 1218 6.1e-131 PREDICTED: heparin sulfate O-sulfotransferase [Tribolium castaneum] -- -- -- -- -- K02513 HS2ST1 heparan sulfate 2-O-sulfotransferase HS2ST1 http://www.genome.jp/dbget-bin/www_bget?ko:K02513 P25722 1014 1.1e-108 Heparin sulfate O-sulfotransferase OS=Drosophila melanogaster GN=Hs2st PE=2 SV=2 PF03567//PF06990//PF00685 Sulfotransferase family//Galactose-3-O-sulfotransferase//Sulfotransferase domain GO:0006687//GO:0009058 glycosphingolipid metabolic process//biosynthetic process GO:0001733//GO:0008146 galactosylceramide sulfotransferase activity//sulfotransferase activity GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3922 Sulfotransferases Cluster-8309.18493 BP_3 4.00 2.29 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18497 BP_3 7.00 0.72 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18498 BP_3 146.25 3.13 2544 189237970 XP_001811996.1 1195 4.5e-128 PREDICTED: protein EMSY [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZUV7 374 2.9e-34 Protein EMSY OS=Danio rerio GN=emsy PE=2 SV=1 PF12905 Endo-alpha-N-acetylgalactosaminidase -- -- GO:0033926 glycopeptide alpha-N-acetylgalactosaminidase activity -- -- -- -- Cluster-8309.18501 BP_3 1.00 1.01 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18502 BP_3 3.64 0.39 741 91094767 XP_967707.1 494 2.5e-47 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P80457 319 2.0e-28 Xanthine dehydrogenase/oxidase OS=Bos taurus GN=XDH PE=1 SV=4 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0046872//GO:0051536 oxidoreductase activity//metal ion binding//iron-sulfur cluster binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.18508 BP_3 540.28 16.86 1836 189234437 XP_966363.2 1791 2.5e-197 PREDICTED: BTB/POZ domain-containing protein 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GLJ1 320 3.8e-28 BTB/POZ domain-containing protein 17 OS=Xenopus laevis GN=btbd17 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18515 BP_3 16.00 0.35 2481 642923899 XP_008193920.1 1187 3.7e-127 PREDICTED: calcitonin gene-related peptide type 1 receptor-like [Tribolium castaneum]>gi|270008144|gb|EFA04592.1| hypothetical protein TcasGA2_TC013321 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08893 501 5.3e-49 Calcitonin receptor OS=Cavia porcellus GN=CALCR PE=2 SV=1 PF02793//PF00002 Hormone receptor domain//7 transmembrane receptor (Secretin family) GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0004930//GO:0004888 G-protein coupled receptor activity//transmembrane signaling receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.18517 BP_3 110.00 7.41 1007 546686182 ERL95562.1 496 2.0e-47 hypothetical protein D910_12823 [Dendroctonus ponderosae] -- -- -- -- -- K07432 ALG13 beta-1,4-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07432 Q5I0K7 308 5.2e-27 UDP-N-acetylglucosamine transferase subunit ALG13 homolog OS=Rattus norvegicus GN=Alg13 PE=1 SV=1 PF04101 Glycosyltransferase family 28 C-terminal domain -- -- GO:0016758 transferase activity, transferring hexosyl groups -- -- KOG3349 Predicted glycosyltransferase Cluster-8309.18518 BP_3 388.53 4.65 4319 546682907 ERL92786.1 1051 3.8e-111 hypothetical protein D910_10094 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P53184 285 1.0e-23 Nicotinamidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNC1 PE=1 SV=1 PF13499//PF13405//PF13833//PF12763//PF12861//PF00036//PF13202//PF00857 EF-hand domain pair//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//Anaphase-promoting complex subunit 11 RING-H2 finger//EF hand//EF hand//Isochorismatase family GO:0016567//GO:0008152 protein ubiquitination//metabolic process GO:0004842//GO:0005515//GO:0003824//GO:0005509 ubiquitin-protein transferase activity//protein binding//catalytic activity//calcium ion binding GO:0005680 anaphase-promoting complex KOG4003 Pyrazinamidase/nicotinamidase PNC1 Cluster-8309.1852 BP_3 336.00 9.93 1923 270015110 EFA11558.1 1982 1.9e-219 cytochrome P450 307A1 [Tribolium castaneum] -- -- -- -- -- K14939 spo, spok, CYP307A cytochrome P450, family 307, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K14939 Q9VRM7 1304 3.2e-142 Cytochrome P450 307a1 OS=Drosophila melanogaster GN=spo PE=1 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.18521 BP_3 25.09 0.38 3458 642916726 XP_008192366.1 1461 8.7e-159 PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum]>gi|642916728|ref|XP_008192372.1| PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18525 BP_3 2.00 3.23 306 546686701 ERL95808.1 176 7.7e-11 hypothetical protein D910_00344, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18530 BP_3 37.57 0.54 3653 642914904 XP_008190437.1 1307 6.6e-141 PREDICTED: aldehyde dehydrogenase 5, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T1L0 293 1.0e-24 Aldehyde dehydrogenase family 16 member A1 OS=Rattus norvegicus GN=Aldh16a1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.18537 BP_3 13.45 1.81 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18539 BP_3 20.00 0.94 1322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18542 BP_3 87.29 1.30 3539 642915323 XP_008190571.1 1587 2.2e-173 PREDICTED: valine--tRNA ligase [Tribolium castaneum]>gi|270003973|gb|EFA00421.1| hypothetical protein TcasGA2_TC003272 [Tribolium castaneum] 470518689 XM_004353314.1 50 2.57435e-14 Acanthamoeba castellanii str. Neff valine-tRNA ligase (ACA1_300880) mRNA, complete cds K01873 VARS, valS valyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01873 Q9Z1Q9 1268 8.8e-138 Valine--tRNA ligase OS=Mus musculus GN=Vars PE=2 SV=1 PF04905//PF00133//PF09334//PF08264//PF13603 NAB conserved region 2 (NCD2)//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Anticodon-binding domain of tRNA//Leucyl-tRNA synthetase, Domain 2 GO:0006412//GO:0006418//GO:0045892 translation//tRNA aminoacylation for protein translation//negative regulation of transcription, DNA-templated GO:0005524//GO:0016874//GO:0000166//GO:0002161//GO:0004812 ATP binding//ligase activity//nucleotide binding//aminoacyl-tRNA editing activity//aminoacyl-tRNA ligase activity GO:0005634 nucleus KOG0432 Valyl-tRNA synthetase Cluster-8309.18545 BP_3 33.65 0.69 2656 549438523 AGX25150.1 1412 3.2e-153 serine proteinase inhibitor, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P31696 241 8.0e-19 Agrin OS=Gallus gallus GN=AGRN PE=1 SV=3 PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.18546 BP_3 82.47 1.55 2860 642915323 XP_008190571.1 2634 6.9e-295 PREDICTED: valine--tRNA ligase [Tribolium castaneum]>gi|270003973|gb|EFA00421.1| hypothetical protein TcasGA2_TC003272 [Tribolium castaneum] 470518689 XM_004353314.1 56 9.58762e-18 Acanthamoeba castellanii str. Neff valine-tRNA ligase (ACA1_300880) mRNA, complete cds K01873 VARS, valS valyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01873 Q9U1Q4 1748 1.6e-193 Valine--tRNA ligase OS=Caenorhabditis elegans GN=vrs-2 PE=1 SV=1 PF09334//PF00133//PF04905//PF08264//PF13603 tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//NAB conserved region 2 (NCD2)//Anticodon-binding domain of tRNA//Leucyl-tRNA synthetase, Domain 2 GO:0045892//GO:0006418//GO:0006412 negative regulation of transcription, DNA-templated//tRNA aminoacylation for protein translation//translation GO:0002161//GO:0004812//GO:0000166//GO:0016874//GO:0005524 aminoacyl-tRNA editing activity//aminoacyl-tRNA ligase activity//nucleotide binding//ligase activity//ATP binding GO:0005634 nucleus KOG0432 Valyl-tRNA synthetase Cluster-8309.18548 BP_3 3.00 1.18 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18549 BP_3 93.72 3.13 1733 642931509 XP_968544.2 855 8.1e-89 PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|642931511|ref|XP_008196616.1| PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DC8 691 3.5e-71 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Homo sapiens GN=ECHDC3 PE=1 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.18550 BP_3 172.01 2.72 3337 91080139 XP_968438.1 3370 0.0e+00 PREDICTED: polyphosphoinositide phosphatase [Tribolium castaneum]>gi|270005661|gb|EFA02109.1| hypothetical protein TcasGA2_TC007753 [Tribolium castaneum] 755878609 XM_005184732.2 66 3.09401e-23 PREDICTED: Musca domestica polyphosphoinositide phosphatase (LOC101887510), mRNA -- -- -- -- Q91WF7 1979 3.0e-220 Polyphosphoinositide phosphatase OS=Mus musculus GN=Fig4 PE=1 SV=1 PF02383 SacI homology domain -- -- GO:0042578 phosphoric ester hydrolase activity -- -- KOG1888 Putative phosphoinositide phosphatase Cluster-8309.18554 BP_3 176.16 6.33 1634 642912701 XP_970424.2 1272 3.4e-137 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q7XJS0 444 1.4e-42 Histone-lysine N-methyltransferase ASHR1 OS=Arabidopsis thaliana GN=ASHR1 PE=2 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.18555 BP_3 220.49 7.78 1658 91076528 XP_973650.1 1936 3.5e-214 PREDICTED: U3 small nucleolar RNA-associated protein 15 homolog [Tribolium castaneum]>gi|270002401|gb|EEZ98848.1| hypothetical protein TcasGA2_TC004458 [Tribolium castaneum] -- -- -- -- -- K14549 UTP15 U3 small nucleolar RNA-associated protein 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14549 A7MB12 1017 5.2e-109 U3 small nucleolar RNA-associated protein 15 homolog OS=Bos taurus GN=UTP15 PE=2 SV=1 PF00400//PF09384 WD domain, G-beta repeat//UTP15 C terminal GO:0006364 rRNA processing GO:0005515 protein binding GO:0005730 nucleolus KOG0310 Conserved WD40 repeat-containing protein Cluster-8309.18557 BP_3 252.00 14.01 1159 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13639//PF00097//PF17122//PF17123//PF12678//PF14634//PF12861 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.18558 BP_3 20.55 2.49 690 478255213 ENN75442.1 378 6.6e-34 hypothetical protein YQE_07993, partial [Dendroctonus ponderosae] -- -- -- -- -- K00953 FLAD1 FAD synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00953 Q68EH8 210 8.2e-16 FAD synthase OS=Danio rerio GN=flad1 PE=2 SV=1 PF06925 Monogalactosyldiacylglycerol (MGDG) synthase GO:0009247 glycolipid biosynthetic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.1856 BP_3 1997.95 85.05 1424 91079032 XP_974956.1 1427 3.1e-155 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270003667|gb|EFA00115.1| hypothetical protein TcasGA2_TC002931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 209 2.2e-15 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.18562 BP_3 22.97 0.48 2583 478253799 ENN74091.1 2589 1.0e-289 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 Q9V6K1 1624 3.4e-179 Tripeptidyl-peptidase 2 OS=Drosophila melanogaster GN=TppII PE=1 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.18563 BP_3 92.05 1.17 4075 642918805 XP_008191593.1 2427 9.9e-271 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 1598 5.5e-176 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0208 Cation transport ATPase Cluster-8309.1857 BP_3 20.90 0.55 2110 209418846 ACI46638.1 1944 5.2e-215 serine proteinase [Portunus trituberculatus] 209418845 FJ360742.1 1294 0 Portunus trituberculatus strain LZW serine proteinase (SP) mRNA, complete cds K01316 PRSS7 protease, serine, 7 (enterokinase) http://www.genome.jp/dbget-bin/www_bget?ko:K01316 P21902 538 2.3e-53 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.18570 BP_3 49.14 1.09 2463 546680809 ERL91015.1 1217 1.2e-130 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 1134 2.1e-122 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.18571 BP_3 110.26 4.45 1485 642915229 XP_008190531.1 1158 5.1e-124 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 676 1.6e-69 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18577 BP_3 233.00 6.48 2025 167004254 NP_001107793.1 1029 6.3e-109 empty spiracles [Tribolium castaneum]>gi|162793850|emb|CAP58696.1| empty spiracles [Tribolium castaneum]>gi|270014246|gb|EFA10694.1| empty spiracles [Tribolium castaneum] 242276439 GQ214558.1 53 3.14432e-16 Petromyzon marinus EmxB mRNA, partial cds K09317 EMX homeobox protein EMX http://www.genome.jp/dbget-bin/www_bget?ko:K09317 P18488 471 1.3e-45 Homeotic protein empty spiracles OS=Drosophila melanogaster GN=ems PE=2 SV=2 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- KOG0843 Transcription factor EMX1 and related HOX domain proteins Cluster-8309.18582 BP_3 6.53 1.54 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18587 BP_3 352.45 8.32 2333 91087517 XP_969270.1 1320 1.3e-142 PREDICTED: phosphatidylinositol glycan anchor biosynthesis class U protein [Tribolium castaneum]>gi|270010669|gb|EFA07117.1| hypothetical protein TcasGA2_TC010108 [Tribolium castaneum] -- -- -- -- -- K05293 PIGU phosphatidylinositol glycan, class U http://www.genome.jp/dbget-bin/www_bget?ko:K05293 Q9H490 702 2.5e-72 Phosphatidylinositol glycan anchor biosynthesis class U protein OS=Homo sapiens GN=PIGU PE=1 SV=3 PF06728 GPI transamidase subunit PIG-U GO:0006506 GPI anchor biosynthetic process -- -- GO:0016021//GO:0044425 integral component of membrane//membrane part KOG2552 Major facilitator superfamily permease - Cdc91p Cluster-8309.1859 BP_3 9.00 0.44 1274 4502473 NP_001722.1 872 6.4e-91 protein BTG1 [Homo sapiens]>gi|40363261|ref|NP_031595.1| protein BTG1 [Mus musculus]>gi|388454252|ref|NP_001253601.1| protein BTG1 [Macaca mulatta]>gi|55638631|ref|XP_509262.1| PREDICTED: protein BTG1 [Pan troglodytes]>gi|297692583|ref|XP_002823624.1| PREDICTED: protein BTG1 [Pongo abelii]>gi|332221102|ref|XP_003259699.1| PREDICTED: protein BTG1 [Nomascus leucogenys]>gi|395820084|ref|XP_003783405.1| PREDICTED: protein BTG1 [Otolemur garnettii]>gi|466007884|ref|XP_004269594.1| PREDICTED: protein BTG1 [Orcinus orca]>gi|472361496|ref|XP_004400342.1| PREDICTED: protein BTG1 [Odobenus rosmarus divergens]>gi|507929255|ref|XP_004675875.1| PREDICTED: protein BTG1 [Condylura cristata]>gi|544472051|ref|XP_005571906.1| PREDICTED: protein BTG1 [Macaca fascicularis]>gi|585166856|ref|XP_006735527.1| PREDICTED: protein BTG1 [Leptonychotes weddellii]>gi|586538076|ref|XP_006923886.1| PREDICTED: protein BTG1 [Pteropus alecto]>gi|602727527|ref|XP_007449210.1| PREDICTED: protein BTG1-like [Lipotes vexillifer]>gi|724924995|ref|XP_010382240.1| PREDICTED: protein BTG1 [Rhinopithecus roxellana]>gi|743708654|ref|XP_010947737.1| PREDICTED: protein BTG1 [Camelus bactrianus]>gi|744575897|ref|XP_010982160.1| PREDICTED: protein BTG1 [Camelus dromedarius]>gi|759124628|ref|XP_011360074.1| PREDICTED: protein BTG1 [Pteropus vampyrus]>gi|795451035|ref|XP_011887073.1| PREDICTED: protein BTG1 [Cercocebus atys]>gi|795662548|ref|XP_011743019.1| PREDICTED: protein BTG1 [Macaca nemestrina]>gi|826349485|ref|XP_012519471.1| PREDICTED: protein BTG1 [Propithecus coquereli]>gi|829818871|ref|XP_012630695.1| PREDICTED: protein BTG1 [Microcebus murinus]>gi|59799172|sp|P62324.1|BTG1_HUMAN RecName: Full=Protein BTG1; AltName: Full=B-cell translocation gene 1 protein>gi|61220033|sp|P62325.1|BTG1_MOUSE RecName: Full=Protein BTG1; AltName: Full=B-cell translocation gene 1 protein>gi|29509|emb|CAA43435.1| BTG1 [Homo sapiens]>gi|50188|emb|CAA78902.1| btg1 [Mus musculus]>gi|248645|gb|AAA08538.1| BTG1 [Homo sapiens]>gi|293306|gb|AAA37327.1| B-cell translocation gene-1 protein [Mus musculus]>gi|13905098|gb|AAH06834.1| B-cell translocation gene 1, anti-proliferative [Mus musculus]>gi|16876972|gb|AAH16759.1| B-cell translocation gene 1, anti-proliferative [Homo sapiens]>gi|17390724|gb|AAH18309.1| B-cell translocation gene 1, anti-proliferative [Mus musculus]>gi|40674077|gb|AAH64953.1| B-cell translocation gene 1, anti-proliferative [Homo sapiens]>gi|48145869|emb|CAG33157.1| BTG1 [Homo sapiens]>gi|49456521|emb|CAG46581.1| BTG1 [Homo sapiens]>gi|54696540|gb|AAV38642.1| B-cell translocation gene 1, anti-proliferative [Homo sapiens]>gi|54696542|gb|AAV38643.1| B-cell translocation gene 1, anti-proliferative [Homo sapiens]>gi|54696544|gb|AAV38644.1| B-cell translocation gene 1, anti-proliferative [Homo sapiens]>gi|56553113|gb|AAV97814.1| B-cell translocation gene 1, anti-proliferative [Homo sapiens]>gi|61356873|gb|AAX41299.1| B-cell translocation gene 1 [synthetic construct]>gi|61356882|gb|AAX41300.1| B-cell translocation gene 1 [synthetic construct]>gi|61356887|gb|AAX41301.1| B-cell translocation gene 1 [synthetic construct]>gi|74146379|dbj|BAE28951.1| unnamed protein product [Mus musculus]>gi|119617873|gb|EAW97467.1| B-cell translocation gene 1, anti-proliferative, isoform CRA_b [Homo sapiens]>gi|157928490|gb|ABW03541.1| B-cell translocation gene 1, anti-proliferative [synthetic construct]>gi|157929120|gb|ABW03845.1| B-cell translocation gene 1, anti-proliferative [synthetic construct]>gi|189053853|dbj|BAG36114.1| unnamed protein product [Homo sapiens]>gi|261860104|dbj|BAI46574.1| B-cell translocation gene 1, anti-proliferative [synthetic construct]>gi|431892113|gb|ELK02560.1| Protein BTG1 [Pteropus alecto]>gi|649098790|gb|AIC48376.1| BTG1, partial [synthetic construct] 209447059 NM_001731.2 1268 0 Homo sapiens B-cell translocation gene 1, anti-proliferative (BTG1), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 P62325 872 2.6e-92 Protein BTG1 OS=Mus musculus GN=Btg1 PE=2 SV=1 PF04805 E10-like protein conserved region GO:0043434//GO:0042981//GO:0030308//GO:0008285//GO:0006479//GO:0016477//GO:0045663//GO:0006979//GO:0045603//GO:0055114//GO:0007283//GO:0006355//GO:0043085//GO:0045766 response to peptide hormone//regulation of apoptotic process//negative regulation of cell growth//negative regulation of cell proliferation//protein methylation//cell migration//positive regulation of myoblast differentiation//response to oxidative stress//positive regulation of endothelial cell differentiation//oxidation-reduction process//spermatogenesis//regulation of transcription, DNA-templated//positive regulation of catalytic activity//positive regulation of angiogenesis GO:0019900//GO:0016972//GO:0003712 kinase binding//thiol oxidase activity//transcription cofactor activity GO:0005667//GO:0005634//GO:0005737 transcription factor complex//nucleus//cytoplasm -- -- Cluster-8309.18591 BP_3 839.83 24.94 1915 189241276 XP_974567.2 1749 1.9e-192 PREDICTED: guanine nucleotide-binding protein-like 3 homolog [Tribolium castaneum]>gi|270014031|gb|EFA10479.1| hypothetical protein TcasGA2_TC012725 [Tribolium castaneum] -- -- -- -- -- K14538 NUG1, GNL3 nuclear GTP-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14538 Q8MT06 1163 7.1e-126 Guanine nucleotide-binding protein-like 3 homolog OS=Drosophila melanogaster GN=Ns1 PE=1 SV=2 PF01926//PF08477//PF03193//PF00025//PF02421 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0005525//GO:0015093 GTPase activity//GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG2484 GTPase Cluster-8309.18592 BP_3 2.00 0.31 607 546672787 ERL84543.1 201 1.9e-13 hypothetical protein D910_01973 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18594 BP_3 21.52 0.59 2055 270011077 EFA07525.1 582 4.4e-57 torso [Tribolium castaneum] 26102928 AK085723.1 38 6.95791e-08 Mus musculus 10 days lactation, adult female mammary gland cDNA, RIKEN full-length enriched library, clone:D730027I24 product:fibroblast growth factor receptor 4, full insert sequence K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 Q91287 500 5.8e-49 Fibroblast growth factor receptor 3 OS=Pleurodeles waltl GN=FGFR3 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.18595 BP_3 1385.63 88.78 1044 91087585 XP_971866.1 401 2.2e-36 PREDICTED: signal peptidase complex subunit 1 [Tribolium castaneum]>gi|270010698|gb|EFA07146.1| hypothetical protein TcasGA2_TC010137 [Tribolium castaneum] -- -- -- -- -- K12946 SPCS1 signal peptidase complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12946 Q9VAL0 285 2.5e-24 Signal peptidase complex subunit 1 OS=Drosophila melanogaster GN=Spase12 PE=1 SV=2 PF06645 Microsomal signal peptidase 12 kDa subunit (SPC12) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex KOG4112 Signal peptidase subunit Cluster-8309.18596 BP_3 131.25 3.81 1954 332373444 AEE61863.1 830 7.2e-86 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 698 6.0e-72 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF13241//PF01266//PF03435//PF01134//PF02558//PF00056//PF00070//PF00899//PF03721//PF01494//PF07992//PF02737//PF02254 Putative NAD(P)-binding//FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//ThiF family//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//TrkA-N domain GO:0006574//GO:0006550//GO:0015940//GO:0006568//GO:0006554//GO:0006779//GO:0008033//GO:0055114//GO:0018874//GO:0006633//GO:0019354//GO:0006813//GO:0006631//GO:0006552 valine catabolic process//isoleucine catabolic process//pantothenate biosynthetic process//tryptophan metabolic process//lysine catabolic process//porphyrin-containing compound biosynthetic process//tRNA processing//oxidation-reduction process//benzoate metabolic process//fatty acid biosynthetic process//siroheme biosynthetic process//potassium ion transport//fatty acid metabolic process//leucine catabolic process GO:0071949//GO:0016616//GO:0003857//GO:0043115//GO:0016491//GO:0051287//GO:0008677//GO:0050660//GO:0008641 FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//precorrin-2 dehydrogenase activity//oxidoreductase activity//NAD binding//2-dehydropantoate 2-reductase activity//flavin adenine dinucleotide binding//small protein activating enzyme activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.1860 BP_3 2.00 0.46 501 -- -- -- -- -- 675681854 XM_002752814.3 498 0 PREDICTED: Callithrix jacchus B-cell translocation gene 1, anti-proliferative (BTG1), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18600 BP_3 27.00 0.62 2391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18603 BP_3 3.80 0.49 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18606 BP_3 114.42 3.08 2081 546677640 ERL88441.1 1535 1.4e-167 hypothetical protein D910_05827 [Dendroctonus ponderosae] -- -- -- -- -- K11214 SHPK sedoheptulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K11214 Q9D5J6 923 5.2e-98 Sedoheptulokinase OS=Mus musculus GN=Shpk PE=1 SV=1 PF00370//PF01926 FGGY family of carbohydrate kinases, N-terminal domain//50S ribosome-binding GTPase GO:0005975 carbohydrate metabolic process GO:0005525//GO:0016773 GTP binding//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.18608 BP_3 238.74 1.67 7175 642929299 XP_008195778.1 9649 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 6488 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF10152//PF00223//PF00647//PF08040//PF00514 Predicted coiled-coil domain-containing protein (DUF2360)//Photosystem I psaA/psaB protein//Elongation factor 1 gamma, conserved domain//MNLL subunit//Armadillo/beta-catenin-like repeat GO:0006118//GO:0006448//GO:0006414//GO:0015979 obsolete electron transport//regulation of translational elongation//translational elongation//photosynthesis GO:0003746//GO:0005515//GO:0003954 translation elongation factor activity//protein binding//NADH dehydrogenase activity GO:0071203//GO:0009579//GO:0005739//GO:0005840//GO:0009522//GO:0016021 WASH complex//thylakoid//mitochondrion//ribosome//photosystem I//integral component of membrane KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.18609 BP_3 215.20 9.44 1391 642929261 XP_008195760.1 268 7.6e-21 PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum]>gi|642929263|ref|XP_008195761.1| PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1861 BP_3 13.00 0.37 1966 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18611 BP_3 17.00 1.23 958 328697481 XP_003240351.1 529 2.8e-51 PREDICTED: uncharacterized protein LOC100573963 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P34257 141 1.1e-07 Transposable element Tc3 transposase OS=Caenorhabditis elegans GN=tc3a PE=1 SV=1 PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.18614 BP_3 3.00 2.52 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18615 BP_3 89.84 2.30 2174 91083483 XP_971803.1 1749 2.2e-192 PREDICTED: tubulin polyglutamylase TTLL4 [Tribolium castaneum]>gi|270010834|gb|EFA07282.1| hypothetical protein TcasGA2_TC014517 [Tribolium castaneum] -- -- -- -- -- K16610 TTLL15 tubulin monoglycylase TTLL15 http://www.genome.jp/dbget-bin/www_bget?ko:K16610 A4Q9E8 267 6.4e-22 Tubulin polyglutamylase TTLL6 OS=Mus musculus GN=Ttll6 PE=2 SV=1 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.1862 BP_3 41.00 2.63 1044 155966234 ABU41071.1 1492 6.7e-163 receptor for activated protein kinase C-like protein [Lepeophtheirus salmonis]>gi|225711916|gb|ACO11804.1| Guanine nucleotide-binding protein subunit beta-like protein [Lepeophtheirus salmonis]>gi|290562157|gb|ADD38475.1| Guanine nucleotide-binding protein subunit beta-like protein [Lepeophtheirus salmonis] 656365360 KJ652971.1 1035 0 Scylla paramamosain receptor for activated protein kinase C1 mRNA, complete cds K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1400 1.3e-153 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat GO:0016310 phosphorylation GO:0005515//GO:0016301 protein binding//kinase activity -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.18624 BP_3 420.77 8.25 2751 642913566 XP_008201065.1 2843 0.0e+00 PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913568|ref|XP_008201066.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913570|ref|XP_008201067.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913572|ref|XP_008201068.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum] 642913571 XM_008202846.1 666 0 PREDICTED: Tribolium castaneum monocarboxylate transporter 12-like (LOC661034), transcript variant X4, mRNA -- -- -- -- Q6GM59 293 7.8e-25 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.18625 BP_3 121.52 3.52 1955 501296544 BAN20989.1 1310 1.6e-141 tyrosyl-tRNA synthetase [Riptortus pedestris] -- -- -- -- -- K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q6TGS6 1236 2.5e-134 Tyrosine--tRNA ligase, cytoplasmic OS=Danio rerio GN=yars PE=2 SV=2 PF00579//PF01588 tRNA synthetases class I (W and Y)//Putative tRNA binding domain GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812//GO:0000049 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity//tRNA binding -- -- KOG2144 Tyrosyl-tRNA synthetase, cytoplasmic Cluster-8309.18626 BP_3 6.33 1.23 539 389609055 BAM18139.1 332 1.1e-28 tyrosyl-tRNA synthetase [Papilio xuthus] -- -- -- -- -- K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q6TGS6 319 1.5e-28 Tyrosine--tRNA ligase, cytoplasmic OS=Danio rerio GN=yars PE=2 SV=2 PF05396 Phage T7 capsid assembly protein GO:0019069 viral capsid assembly -- -- -- -- KOG2241 tRNA-binding protein Cluster-8309.18630 BP_3 180.71 1.92 4818 91092828 XP_968011.1 3111 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 4 [Tribolium castaneum]>gi|270004790|gb|EFA01238.1| gluon [Tribolium castaneum] -- -- -- -- -- K06675 SMC4 structural maintenance of chromosome 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06675 P50532 2145 2.4e-239 Structural maintenance of chromosomes protein 4 OS=Xenopus laevis GN=smc4 PE=1 SV=1 PF06160//PF13304//PF00955//PF00005//PF06470 Septation ring formation regulator, EzrA//AAA domain, putative AbiEii toxin, Type IV TA system//HCO3- transporter family//ABC transporter//SMC proteins Flexible Hinge Domain GO:0006820//GO:0006259//GO:0000921//GO:0051276 anion transport//DNA metabolic process//septin ring assembly//chromosome organization GO:0016887//GO:0005515//GO:0005524 ATPase activity//protein binding//ATP binding GO:0005694//GO:0005940//GO:0016021 chromosome//septin ring//integral component of membrane KOG0996 Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) Cluster-8309.18631 BP_3 390.25 5.07 4003 91084191 XP_967340.1 2840 0.0e+00 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270008779|gb|EFA05227.1| hypothetical protein TcasGA2_TC015371 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 2117 3.5e-236 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF05834//PF07992//PF10399//PF05199 GMC oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//GMC oxidoreductase GO:0006563//GO:0006066//GO:0006119//GO:0006118//GO:0016117//GO:0006566//GO:0055114//GO:0006544//GO:0015992 L-serine metabolic process//alcohol metabolic process//oxidative phosphorylation//obsolete electron transport//carotenoid biosynthetic process//threonine metabolic process//oxidation-reduction process//glycine metabolic process//proton transport GO:0016614//GO:0016705//GO:0008121//GO:0016491//GO:0008812//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ubiquinol-cytochrome-c reductase activity//oxidoreductase activity//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.18633 BP_3 5.00 0.37 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18638 BP_3 486.70 7.56 3396 642922142 XP_970966.2 2366 9.8e-264 PREDICTED: uncharacterized protein LOC659581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05817//PF01663//PF00884 Oligosaccharyltransferase subunit Ribophorin II//Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0006487//GO:0008152 protein N-linked glycosylation//metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity GO:0008250//GO:0016021 oligosaccharyltransferase complex//integral component of membrane -- -- Cluster-8309.18641 BP_3 141.65 3.71 2134 642931074 XP_974160.2 683 8.8e-69 PREDICTED: stimulator of interferon genes protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TBT3 199 4.8e-14 Stimulator of interferon genes protein OS=Mus musculus GN=Tmem173 PE=1 SV=2 PF15009 Transmembrane protein 173 GO:0032481//GO:0002218 positive regulation of type I interferon production//activation of innate immune response -- -- -- -- -- -- Cluster-8309.18644 BP_3 46.58 3.25 983 820805560 AKG92771.1 531 1.7e-51 daugherless [Leptinotarsa decemlineata] 805782450 XM_012284176.1 90 4.05405e-37 PREDICTED: Megachile rotundata protein daughterless (LOC100877694), transcript variant X15, mRNA K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P11420 381 1.7e-35 Protein daughterless OS=Drosophila melanogaster GN=da PE=1 SV=1 PF00010//PF02854 Helix-loop-helix DNA-binding domain//MIF4G domain -- -- GO:0005515//GO:0046983//GO:0003723 protein binding//protein dimerization activity//RNA binding -- -- KOG3910 Helix loop helix transcription factor Cluster-8309.18647 BP_3 4.00 0.37 816 568258029 ETN66225.1 279 2.4e-22 ubiquinol-cytochrome c reductase complex 14 kDa protein [Anopheles darlingi] -- -- -- -- -- K00417 QCR7, UQCRB ubiquinol-cytochrome c reductase subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00417 P00129 236 9.4e-19 Cytochrome b-c1 complex subunit 7 OS=Bos taurus GN=UQCRB PE=1 SV=3 PF02271 Ubiquinol-cytochrome C reductase complex 14kD subunit GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750 mitochondrial respiratory chain complex III KOG3440 Ubiquinol cytochrome c reductase, subunit QCR7 Cluster-8309.18648 BP_3 82.72 2.60 1825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18653 BP_3 6.00 1.03 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18659 BP_3 61.83 2.89 1324 642919913 XP_008192122.1 654 1.3e-65 PREDICTED: transcription factor SOX-13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1866 BP_3 6.00 0.51 861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18660 BP_3 37.35 1.45 1534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18661 BP_3 665.00 30.52 1342 642933995 XP_008197596.1 880 7.9e-92 PREDICTED: uncharacterized protein LOC100142086 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06423//PF12822 GWT1//Protein of unknown function (DUF3816) GO:0006506//GO:0006810 GPI anchor biosynthetic process//transport GO:0016746//GO:0005215 transferase activity, transferring acyl groups//transporter activity GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.18663 BP_3 1.00 0.32 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00440 Bacterial regulatory proteins, tetR family -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.18664 BP_3 34.00 5.10 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18669 BP_3 447.38 6.28 3728 642920032 XP_008192175.1 1056 8.6e-112 PREDICTED: uncharacterized protein LOC103312676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1A5V7 533 1.6e-52 Transmembrane protein 41B OS=Danio rerio GN=tmem41b PE=2 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG3140 Predicted membrane protein Cluster-8309.18670 BP_3 83.99 1.13 3867 270005331 EFA01779.1 1056 8.9e-112 hypothetical protein TcasGA2_TC007380 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1A5V7 386 1.8e-35 Transmembrane protein 41B OS=Danio rerio GN=tmem41b PE=2 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG3140 Predicted membrane protein Cluster-8309.18675 BP_3 104.00 6.04 1121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18676 BP_3 63.68 1.67 2126 826489905 XP_012539874.1 294 1.1e-23 PREDICTED: uncharacterized protein LOC105838688 [Monomorium pharaonis]>gi|826489910|ref|XP_012539875.1| PREDICTED: uncharacterized protein LOC105838688 [Monomorium pharaonis]>gi|826489915|ref|XP_012539876.1| PREDICTED: uncharacterized protein LOC105838688 [Monomorium pharaonis] 815810415 XM_012370684.1 69 4.21382e-25 PREDICTED: Linepithema humile uncharacterized LOC105674405 (LOC105674405), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18679 BP_3 21.00 0.47 2428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18680 BP_3 19.00 0.44 2369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18681 BP_3 7.00 0.33 1323 828177640 AKK25143.1 279 3.8e-22 odorant binding protein 19 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27017 156 2.9e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395//PF00584//PF09061//PF07813 PBP/GOBP family//SecE/Sec61-gamma subunits of protein translocation complex//Stirrup//LTXXQ motif family protein GO:0006605//GO:0006886 protein targeting//intracellular protein transport GO:0016788//GO:0005549 hydrolase activity, acting on ester bonds//odorant binding GO:0016020//GO:0042597 membrane//periplasmic space -- -- Cluster-8309.18687 BP_3 117.63 5.12 1400 642923865 XP_966645.3 1281 2.6e-138 PREDICTED: TBC1 domain family member 20 isoform X2 [Tribolium castaneum] 462282558 APGK01057257.1 55 1.66729e-17 Dendroctonus ponderosae Seq01057267, whole genome shotgun sequence -- -- -- -- Q9D9I4 693 1.6e-71 TBC1 domain family member 20 OS=Mus musculus GN=Tbc1d20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2595 Predicted GTPase activator protein Cluster-8309.18688 BP_3 4.00 1.10 466 795008009 XP_011864941.1 234 2.2e-17 PREDICTED: uncharacterized protein LOC105560403, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18689 BP_3 42.00 1.27 1891 795008352 XP_011883559.1 291 2.2e-23 PREDICTED: uncharacterized protein LOC105570729 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.1869 BP_3 3.00 0.55 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18692 BP_3 1.00 0.34 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18695 BP_3 434.82 2.73 7980 123407101 XP_001302933.1 225 4.2e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.5e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1870 BP_3 5.00 0.33 1032 270015402 EFA11850.1 464 1.1e-43 hypothetical protein TcasGA2_TC005090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18700 BP_3 14.66 0.34 2342 478262447 ENN81118.1 1422 2.0e-154 hypothetical protein YQE_02486, partial [Dendroctonus ponderosae] -- -- -- -- -- K10746 EXO1 exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10746 Q24558 1088 4.3e-117 Exonuclease 1 OS=Drosophila melanogaster GN=tos PE=1 SV=1 PF00752//PF13414//PF13181//PF00867 XPG N-terminal domain//TPR repeat//Tetratricopeptide repeat//XPG I-region GO:0006281 DNA repair GO:0004518//GO:0005515 nuclease activity//protein binding -- -- KOG2518 5'-3' exonuclease Cluster-8309.18701 BP_3 150.07 2.35 3368 546679820 ERL90212.1 1294 2.0e-139 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BQA5 823 3.3e-86 Histone H4 transcription factor OS=Homo sapiens GN=HINFP PE=1 SV=2 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.18703 BP_3 11.51 0.39 1727 270010175 EFA06623.1 1474 1.3e-160 hypothetical protein TcasGA2_TC009541 [Tribolium castaneum] -- -- -- -- -- K10481 BTBD9 BTB/POZ domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10481 A4IFG2 807 1.2e-84 BTB/POZ domain-containing protein 9 OS=Bos taurus GN=BTBD9 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.18705 BP_3 81.55 4.08 1254 642922630 XP_970967.2 699 7.2e-71 PREDICTED: probable RNA methyltransferase CG11342 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VZD2 524 5.8e-52 Probable RNA methyltransferase CG11342 OS=Drosophila melanogaster GN=CG11342 PE=3 SV=1 PF02390//PF06859//PF08241 Putative methyltransferase//Bicoid-interacting protein 3 (Bin3)//Methyltransferase domain GO:0008152//GO:0009451//GO:0006400//GO:0008033 metabolic process//RNA modification//tRNA modification//tRNA processing GO:0008168//GO:0008176 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG2899 Predicted methyltransferase Cluster-8309.18707 BP_3 15.35 0.46 1897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18708 BP_3 280.64 3.85 3807 642925645 XP_008194653.1 4733 0.0e+00 PREDICTED: potassium voltage-gated channel subfamily H member 6-like isoform X1 [Tribolium castaneum] 642925644 XM_008196431.1 608 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel subfamily H member 6-like (LOC662676), transcript variant X1, mRNA K04910 KCNH7 potassium voltage-gated channel Eag-related subfamily H member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04910 Q9ER47 1874 5.1e-208 Potassium voltage-gated channel subfamily H member 7 OS=Mus musculus GN=Kcnh7 PE=2 SV=2 PF00989//PF08447//PF00520 PAS fold//PAS fold//Ion transport protein GO:0006355//GO:0055085//GO:0006811 regulation of transcription, DNA-templated//transmembrane transport//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain Cluster-8309.18709 BP_3 57.13 0.97 3133 642921556 XP_008192422.1 2750 2.7e-308 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- K14616 CUBN cubilin http://www.genome.jp/dbget-bin/www_bget?ko:K14616 Q9JLB4 1685 3.4e-186 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF07645//PF00008//PF05693 Calcium-binding EGF domain//EGF-like domain//Glycogen synthase GO:0005985//GO:0005978//GO:0005982 sucrose metabolic process//glycogen biosynthetic process//starch metabolic process GO:0005515//GO:0005509//GO:0004373 protein binding//calcium ion binding//glycogen (starch) synthase activity -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.18713 BP_3 27.16 0.71 2144 91082807 XP_968134.1 902 3.6e-94 PREDICTED: general transcription factor IIF subunit 2 [Tribolium castaneum]>gi|270007102|gb|EFA03550.1| hypothetical protein TcasGA2_TC013555 [Tribolium castaneum] 755881816 XM_005185870.2 95 1.49651e-39 PREDICTED: Musca domestica general transcription factor IIF subunit 2 (LOC101901202), mRNA K03139 TFIIF2, GTF2F2, TFG2 transcription initiation factor TFIIF subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03139 P41900 683 3.6e-70 General transcription factor IIF subunit 2 OS=Drosophila melanogaster GN=TfIIFbeta PE=2 SV=2 PF02270 Transcription initiation factor IIF, beta subunit GO:0006367//GO:0006366 transcription initiation from RNA polymerase II promoter//transcription from RNA polymerase II promoter GO:0003824//GO:0005524 catalytic activity//ATP binding GO:0005674 transcription factor TFIIF complex KOG2905 Transcription initiation factor IIF, small subunit (RAP30) Cluster-8309.18714 BP_3 139.00 6.44 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01736 Polyomavirus agnoprotein -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.18716 BP_3 73.15 2.71 1593 548544410 XP_005753889.1 472 1.9e-44 PREDICTED: zinc finger protein 84-like [Pundamilia nyererei] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 434 2.0e-41 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF13465//PF07776//PF13912//PF04810//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0030127//GO:0005634 COPII vesicle coat//nucleus -- -- Cluster-8309.18717 BP_3 10.32 0.52 1255 91081335 XP_967042.1 1025 1.1e-108 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X2 [Tribolium castaneum]>gi|270005182|gb|EFA01630.1| hypothetical protein TcasGA2_TC007200 [Tribolium castaneum] -- -- -- -- -- K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 811 3.0e-85 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 -- -- GO:0005977//GO:0005975 glycogen metabolic process//carbohydrate metabolic process GO:0004553//GO:0005516 hydrolase activity, hydrolyzing O-glycosyl compounds//calmodulin binding -- -- KOG3635 Phosphorylase kinase Cluster-8309.1872 BP_3 46.00 19.20 406 270006771 EFA03219.1 328 2.4e-28 hypothetical protein TcasGA2_TC013139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 229 3.0e-18 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.18721 BP_3 14.73 0.64 1408 91076100 XP_968498.1 1228 3.7e-132 PREDICTED: neurotrimin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O97394 137 4.9e-07 Protein sidekick OS=Drosophila melanogaster GN=sdk PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18723 BP_3 53.61 2.14 1501 642911636 XP_008200681.1 1225 8.8e-132 PREDICTED: kin of IRRE-like protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18727 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1873 BP_3 2.00 18.04 246 270006771 EFA03219.1 179 2.8e-11 hypothetical protein TcasGA2_TC013139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91627 137 8.4e-08 Larval cuticle protein 1 OS=Drosophila miranda GN=Lcp1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18734 BP_3 370.22 2.99 6252 189235646 XP_968349.2 2120 6.0e-235 PREDICTED: peripheral plasma membrane protein CASK isoform X4 [Tribolium castaneum] 642917490 XM_963256.3 673 0 PREDICTED: Tribolium castaneum peripheral plasma membrane protein CASK (LOC656749), transcript variant X4, mRNA K06103 CASK calcium/calmodulin-dependent serine protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06103 Q24210 1852 3.0e-205 Peripheral plasma membrane protein CASK OS=Drosophila melanogaster GN=CASK PE=1 SV=4 PF13180//PF14604//PF00595//PF00018//PF01003 PDZ domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain//Flavivirus capsid protein C -- -- GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0019028 viral capsid KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.18735 BP_3 187.25 4.16 2461 91088003 XP_973796.1 525 2.1e-50 PREDICTED: putative RNA-binding protein Luc7-like 2 [Tribolium castaneum]>gi|270011896|gb|EFA08344.1| hypothetical protein TcasGA2_TC005987 [Tribolium castaneum] -- -- -- -- -- K13212 LUC7L2 RNA-binding protein Luc7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13212 Q9Y383 397 6.1e-37 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens GN=LUC7L2 PE=1 SV=2 PF07851//PF03194//PF01442 TMPIT-like protein//LUC7 N_terminus//Apolipoprotein A1/A4/E domain GO:0006869//GO:0042157//GO:0006376 lipid transport//lipoprotein metabolic process//mRNA splice site selection GO:0008289//GO:0003729 lipid binding//mRNA binding GO:0005685//GO:0016021//GO:0005576 U1 snRNP//integral component of membrane//extracellular region KOG0796 Spliceosome subunit Cluster-8309.18736 BP_3 9.00 2.31 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18737 BP_3 1.00 0.31 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18739 BP_3 24.25 0.43 3041 478256841 ENN77016.1 1079 1.5e-114 hypothetical protein YQE_06510, partial [Dendroctonus ponderosae]>gi|546673799|gb|ERL85343.1| hypothetical protein D910_02763 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V785 768 7.2e-80 SH3 domain-binding protein 5 homolog OS=Drosophila melanogaster GN=pcs PE=1 SV=4 PF01484//PF07851 Nematode cuticle collagen N-terminal domain//TMPIT-like protein -- -- GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.18740 BP_3 69.42 1.77 2186 642911317 XP_008199368.1 211 4.8e-14 PREDICTED: uncharacterized protein LOC103314647 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09508 Lacto-N-biose phosphorylase -- -- GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.18741 BP_3 319.55 6.10 2816 478250852 ENN71341.1 1034 2.3e-109 hypothetical protein YQE_11956, partial [Dendroctonus ponderosae]>gi|546678340|gb|ERL88982.1| hypothetical protein D910_06360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VPK7 587 6.5e-59 Putative tRNA pseudouridine synthase Pus10 OS=Drosophila melanogaster GN=Pus10 PE=2 SV=2 PF02058//PF01416 Guanylin precursor//tRNA pseudouridine synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0009982//GO:0003723//GO:0030250 pseudouridine synthase activity//RNA binding//guanylate cyclase activator activity GO:0005576 extracellular region KOG2364 Predicted pseudouridylate synthase Cluster-8309.18742 BP_3 4.00 0.92 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18744 BP_3 103.66 4.09 1514 478263729 ENN82032.1 1530 3.8e-167 hypothetical protein YQE_01607, partial [Dendroctonus ponderosae] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 B7ZMP1 901 1.3e-95 Probable Xaa-Pro aminopeptidase 3 OS=Mus musculus GN=Xpnpep3 PE=2 SV=1 PF05195 Aminopeptidase P, N-terminal domain -- -- GO:0004177//GO:0030145 aminopeptidase activity//manganese ion binding -- -- KOG2414 Putative Xaa-Pro aminopeptidase Cluster-8309.18745 BP_3 45.53 0.55 4261 478254930 ENN75164.1 895 4.6e-93 hypothetical protein YQE_08277, partial [Dendroctonus ponderosae]>gi|546673344|gb|ERL84970.1| hypothetical protein D910_02393 [Dendroctonus ponderosae] -- -- -- -- -- K18586 COQ4 ubiquinone biosynthesis protein COQ4 http://www.genome.jp/dbget-bin/www_bget?ko:K18586 Q1HPV1 735 6.7e-76 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial OS=Bombyx mori PE=2 SV=1 PF05271//PF05019 Tobravirus 2B protein//Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GO:0006744//GO:0019089 ubiquinone biosynthetic process//transmission of virus -- -- -- -- KOG3244 Protein involved in ubiquinone biosynthesis Cluster-8309.18746 BP_3 73.04 0.73 5138 642917385 XP_008199669.1 1119 5.9e-119 PREDICTED: uncharacterized protein LOC658463 [Tribolium castaneum]>gi|270003013|gb|EEZ99460.1| hypothetical protein TcasGA2_TC000026 [Tribolium castaneum] -- -- -- -- -- K18586 COQ4 ubiquinone biosynthesis protein COQ4 http://www.genome.jp/dbget-bin/www_bget?ko:K18586 Q1HPV1 735 8.1e-76 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial OS=Bombyx mori PE=2 SV=1 PF03153//PF05271//PF05019 Transcription factor IIA, alpha/beta subunit//Tobravirus 2B protein//Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GO:0006367//GO:0019089//GO:0006744 transcription initiation from RNA polymerase II promoter//transmission of virus//ubiquinone biosynthetic process -- -- GO:0005672 transcription factor TFIIA complex KOG3244 Protein involved in ubiquinone biosynthesis Cluster-8309.18749 BP_3 94.35 0.62 7655 817054227 XP_012266426.1 1648 4.0e-180 PREDICTED: phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1 [Athalia rosae] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA -- -- -- -- Q5ZL26 1288 9.1e-140 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF14572//PF00156 Phosphoribosyl synthetase-associated domain//Phosphoribosyl transferase domain GO:0006144//GO:0009165//GO:0006098//GO:0009116 purine nucleobase metabolic process//nucleotide biosynthetic process//pentose-phosphate shunt//nucleoside metabolic process GO:0004749//GO:0000287 ribose phosphate diphosphokinase activity//magnesium ion binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.18750 BP_3 12.06 0.35 1975 332373444 AEE61863.1 817 2.4e-84 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 690 5.2e-71 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF13241//PF03435//PF01266//PF01134//PF02558//PF00056//PF00070//PF00899//PF03721//PF01494//PF02737//PF07992//PF01399//PF02254 Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//ThiF family//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//FAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//PCI domain//TrkA-N domain GO:0006813//GO:0019354//GO:0018874//GO:0006633//GO:0006552//GO:0006631//GO:0015940//GO:0006550//GO:0006574//GO:0055114//GO:0006779//GO:0008033//GO:0006554//GO:0006568 potassium ion transport//siroheme biosynthetic process//benzoate metabolic process//fatty acid biosynthetic process//leucine catabolic process//fatty acid metabolic process//pantothenate biosynthetic process//isoleucine catabolic process//valine catabolic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//tRNA processing//lysine catabolic process//tryptophan metabolic process GO:0051287//GO:0005515//GO:0016491//GO:0043115//GO:0008641//GO:0050660//GO:0008677//GO:0016616//GO:0071949//GO:0003857 NAD binding//protein binding//oxidoreductase activity//precorrin-2 dehydrogenase activity//small protein activating enzyme activity//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//FAD binding//3-hydroxyacyl-CoA dehydrogenase activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.18751 BP_3 293.00 11.97 1472 91090662 XP_974317.1 1378 1.6e-149 PREDICTED: ubiquitin-like domain-containing CTD phosphatase 1 [Tribolium castaneum] -- -- -- -- -- K17618 UBLCP1 ubiquitin-like domain-containing CTD phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17618 Q6DI37 1028 2.5e-110 Ubiquitin-like domain-containing CTD phosphatase 1 OS=Danio rerio GN=ublcp1 PE=2 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG1872 Ubiquitin-specific protease Cluster-8309.18752 BP_3 70.08 2.11 1894 332373444 AEE61863.1 858 4.0e-89 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 724 5.6e-75 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF01134//PF02558//PF00070//PF00056//PF03721//PF00899//PF13241//PF03435//PF01266//PF02254//PF01494//PF07992//PF02737//PF01399 Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//Pyridine nucleotide-disulphide oxidoreductase//lactate/malate dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//ThiF family//Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//TrkA-N domain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//PCI domain GO:0019354//GO:0006633//GO:0018874//GO:0006813//GO:0006631//GO:0006552//GO:0015940//GO:0006574//GO:0006550//GO:0006568//GO:0008033//GO:0006779//GO:0006554//GO:0055114 siroheme biosynthetic process//fatty acid biosynthetic process//benzoate metabolic process//potassium ion transport//fatty acid metabolic process//leucine catabolic process//pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process//tryptophan metabolic process//tRNA processing//porphyrin-containing compound biosynthetic process//lysine catabolic process//oxidation-reduction process GO:0043115//GO:0016491//GO:0005515//GO:0051287//GO:0050660//GO:0008677//GO:0008641//GO:0071949//GO:0016616//GO:0003857 precorrin-2 dehydrogenase activity//oxidoreductase activity//protein binding//NAD binding//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//small protein activating enzyme activity//FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.18756 BP_3 11.00 1.50 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18759 BP_3 22.00 1.24 1147 270015247 EFA11695.1 385 1.7e-34 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404 AsnC-type helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.18761 BP_3 2.20 0.38 574 91092648 XP_969941.1 492 3.3e-47 PREDICTED: tyrosine-protein kinase Drl [Tribolium castaneum]>gi|270014831|gb|EFA11279.1| hypothetical protein TcasGA2_TC010814 [Tribolium castaneum] -- -- -- -- -- K05128 RYK RYK receptor-like tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05128 Q01887 432 1.2e-41 Tyrosine-protein kinase RYK OS=Mus musculus GN=Ryk PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0004713//GO:0005524 protein kinase activity//protein tyrosine kinase activity//ATP binding -- -- KOG1024 Receptor-like protein tyrosine kinase RYK/derailed Cluster-8309.18764 BP_3 8.03 2.27 462 270016741 EFA13187.1 194 9.6e-13 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SVZ6 134 3.6e-07 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.18766 BP_3 5.00 0.36 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18769 BP_3 189.45 4.07 2534 189234109 XP_001813540.1 984 1.3e-103 PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|642912138|ref|XP_008200823.1| PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|270002521|gb|EEZ98968.1| hypothetical protein TcasGA2_TC004823 [Tribolium castaneum] 665818633 XM_008559932.1 56 8.48689e-18 PREDICTED: Microplitis demolitor methyltransferase-like protein 6 (LOC103578761), transcript variant X2, mRNA K00599 METTL6 methyltransferase-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00599 Q8BVH9 764 1.7e-79 Methyltransferase-like protein 6 OS=Mus musculus GN=Mettl6 PE=2 SV=2 PF00106//PF01209//PF01234//PF08241//PF02390//PF05724//PF05175//PF05958 short chain dehydrogenase//ubiE/COQ5 methyltransferase family//NNMT/PNMT/TEMT family//Methyltransferase domain//Putative methyltransferase//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain//tRNA (Uracil-5-)-methyltransferase GO:0009451//GO:0008033//GO:0006396//GO:0006400//GO:0032259//GO:0008152 RNA modification//tRNA processing//RNA processing//tRNA modification//methylation//metabolic process GO:0008176//GO:0008168//GO:0008757//GO:0016491//GO:0008173 tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//oxidoreductase activity//RNA methyltransferase activity -- -- KOG2361 Predicted methyltransferase Cluster-8309.18770 BP_3 20.70 3.20 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18771 BP_3 129.33 2.52 2768 189234109 XP_001813540.1 984 1.4e-103 PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|642912138|ref|XP_008200823.1| PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|270002521|gb|EEZ98968.1| hypothetical protein TcasGA2_TC004823 [Tribolium castaneum] 665818633 XM_008559932.1 56 9.27528e-18 PREDICTED: Microplitis demolitor methyltransferase-like protein 6 (LOC103578761), transcript variant X2, mRNA K00599 METTL6 methyltransferase-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00599 Q8BVH9 764 1.9e-79 Methyltransferase-like protein 6 OS=Mus musculus GN=Mettl6 PE=2 SV=2 PF01234//PF05724//PF05175//PF02390//PF08241//PF05958//PF00106//PF01209 NNMT/PNMT/TEMT family//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain//Putative methyltransferase//Methyltransferase domain//tRNA (Uracil-5-)-methyltransferase//short chain dehydrogenase//ubiE/COQ5 methyltransferase family GO:0009451//GO:0006396//GO:0008033//GO:0032259//GO:0006400//GO:0008152 RNA modification//RNA processing//tRNA processing//methylation//tRNA modification//metabolic process GO:0008176//GO:0008168//GO:0008757//GO:0016491//GO:0008173 tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//oxidoreductase activity//RNA methyltransferase activity -- -- KOG2361 Predicted methyltransferase Cluster-8309.18772 BP_3 44.22 1.34 1887 189234109 XP_001813540.1 664 1.2e-66 PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|642912138|ref|XP_008200823.1| PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|270002521|gb|EEZ98968.1| hypothetical protein TcasGA2_TC004823 [Tribolium castaneum] 665818633 XM_008559932.1 56 6.28961e-18 PREDICTED: Microplitis demolitor methyltransferase-like protein 6 (LOC103578761), transcript variant X2, mRNA K00599 METTL6 methyltransferase-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00599 Q5RDV8 534 6.1e-53 Methyltransferase-like protein 6 OS=Pongo abelii GN=METTL6 PE=2 SV=1 PF01234//PF00106//PF08241//PF05724//PF05175 NNMT/PNMT/TEMT family//short chain dehydrogenase//Methyltransferase domain//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain GO:0032259//GO:0008152 methylation//metabolic process GO:0016491//GO:0008168//GO:0008757 oxidoreductase activity//methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity -- -- KOG2361 Predicted methyltransferase Cluster-8309.18773 BP_3 76.30 7.97 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18776 BP_3 60.00 0.44 6925 642938901 XP_008195529.1 3175 0.0e+00 PREDICTED: FCH and double SH3 domains protein 2 [Tribolium castaneum]>gi|270016165|gb|EFA12613.1| hypothetical protein TcasGA2_TC006854 [Tribolium castaneum] 158286862 XM_308970.4 176 4.58322e-84 Anopheles gambiae str. PEST AGAP006774-PA (AgaP_AGAP006774) mRNA, complete cds -- -- -- -- O94868 971 4.7e-103 F-BAR and double SH3 domains protein 2 OS=Homo sapiens GN=FCHSD2 PE=1 SV=3 PF01997//PF12601//PF14604//PF00018 Translin family//Rubivirus non-structural protein//Variant SH3 domain//SH3 domain GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0003968//GO:0043565//GO:0017111//GO:0016817//GO:0004197//GO:0005515 RNA-directed RNA polymerase activity//sequence-specific DNA binding//nucleoside-triphosphatase activity//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//protein binding GO:0031379 RNA-directed RNA polymerase complex KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.18780 BP_3 6.29 0.31 1256 642913023 XP_008201355.1 1033 1.3e-109 PREDICTED: vacuolar protein sorting-associated protein 72 homolog [Tribolium castaneum] 815809469 XM_012370186.1 67 3.18297e-24 PREDICTED: Linepithema humile vacuolar protein sorting-associated protein 72 homolog (LOC105674081), mRNA K11664 VPS72, TCFL1, YL1 vacuolar protein sorting-associated protein 72 http://www.genome.jp/dbget-bin/www_bget?ko:K11664 Q9VKM6 584 6.4e-59 Vacuolar protein sorting-associated protein 72 homolog OS=Drosophila melanogaster GN=YL-1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2897 DNA-binding protein YL1 and related proteins Cluster-8309.18783 BP_3 474.00 36.36 920 91083333 XP_974927.1 653 1.1e-65 PREDICTED: probable Golgi SNAP receptor complex member 2 [Tribolium castaneum]>gi|270006922|gb|EFA03370.1| hypothetical protein TcasGA2_TC013356 [Tribolium castaneum] -- -- -- -- -- K08496 GOSR2, BOS1 golgi SNAP receptor complex member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08496 Q9VRL2 382 1.2e-35 Probable Golgi SNAP receptor complex member 2 OS=Drosophila melanogaster GN=membrin PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3251 Golgi SNAP receptor complex member Cluster-8309.18786 BP_3 16.00 1.20 934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18789 BP_3 13.00 0.85 1027 91077070 XP_969313.1 198 7.3e-13 PREDICTED: metal transporter CNNM4 [Tribolium castaneum]>gi|270002030|gb|EEZ98477.1| hypothetical protein TcasGA2_TC000970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18790 BP_3 31.00 2.44 904 332377007 AEE63643.1 577 7.3e-57 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 382 1.2e-35 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0007423//GO:0006446//GO:0006413 sensory organ development//regulation of translational initiation//translational initiation GO:0005212//GO:0003743 structural constituent of eye lens//translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.18792 BP_3 59.17 0.51 5856 270002842 EEZ99289.1 2544 3.9e-284 groucho-like protein [Tribolium castaneum] 642914413 XM_008203264.1 619 0 PREDICTED: Tribolium castaneum protein groucho-1-like (LOC655664), transcript variant X2, mRNA -- -- -- -- P16371 1859 4.3e-206 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF10538//PF00400 Immunoreceptor tyrosine-based activation motif//WD domain, G-beta repeat GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.18795 BP_3 5.00 0.32 1047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18798 BP_3 93.46 2.91 1839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18799 BP_3 176.64 11.01 1065 642920715 XP_008192533.1 936 2.0e-98 PREDICTED: TATA-box-binding protein isoform X1 [Tribolium castaneum]>gi|270005208|gb|EFA01656.1| hypothetical protein TcasGA2_TC007228 [Tribolium castaneum] -- -- -- -- -- K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 P53361 651 9.2e-67 TATA-box-binding protein OS=Spodoptera frugiperda GN=Tbp PE=2 SV=1 PF00352 Transcription factor TFIID (or TATA-binding protein, TBP) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding -- -- KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.188 BP_3 183.59 5.86 1801 157110972 XP_001651335.1 2104 1.2e-233 AAEL005685-PA, partial [Aedes aegypti]>gi|108878582|gb|EAT42807.1| AAEL005685-PA, partial [Aedes aegypti] 755853840 XM_011297515.1 96 3.48414e-40 PREDICTED: Musca domestica uncharacterized LOC101899955 (LOC101899955), mRNA -- -- -- -- Q6X0I2 130 4.0e-06 Vitellogenin receptor OS=Solenopsis invicta GN=VgR PE=2 SV=1 PF05026//PF01522//PF05656//PF00057//PF01607 Dcp2, box A domain//Polysaccharide deacetylase//Protein of unknown function (DUF805)//Low-density lipoprotein receptor domain class A//Chitin binding Peritrophin-A domain GO:0006030//GO:0006807//GO:0005975 chitin metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process GO:0005515//GO:0030145//GO:0003723//GO:0016787//GO:0016810//GO:0008061 protein binding//manganese ion binding//RNA binding//hydrolase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.1880 BP_3 15.00 0.79 1210 642911336 XP_008199377.1 537 4.2e-52 PREDICTED: uncharacterized protein LOC103314652 [Tribolium castaneum]>gi|642911338|ref|XP_008199378.1| PREDICTED: uncharacterized protein LOC103314652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18801 BP_3 41.00 1.55 1567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05424 Duffy binding domain GO:0009405//GO:0007165 pathogenesis//signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.18807 BP_3 15.90 0.45 1994 861633222 KMQ90883.1 846 1.0e-87 hypothetical protein RF55_9309 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18809 BP_3 164.35 3.39 2629 189241943 XP_971607.2 1924 1.4e-212 PREDICTED: uncharacterized aarF domain-containing protein kinase 1 [Tribolium castaneum]>gi|270015338|gb|EFA11786.1| hypothetical protein TcasGA2_TC008565 [Tribolium castaneum] -- -- -- -- -- K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 Q5ZMT7 1163 9.8e-126 Uncharacterized aarF domain-containing protein kinase 1 OS=Gallus gallus GN=ADCK1 PE=2 SV=1 PF09788//PF00069 Transmembrane protein 55A//Protein kinase domain GO:0006468//GO:0046856 protein phosphorylation//phosphatidylinositol dephosphorylation GO:0034597//GO:0004672//GO:0005524//GO:0016772 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//protein kinase activity//ATP binding//transferase activity, transferring phosphorus-containing groups -- -- KOG1235 Predicted unusual protein kinase Cluster-8309.18814 BP_3 28.48 0.44 3436 91078790 XP_969765.1 2074 7.2e-230 PREDICTED: retinoblastoma-binding protein 5 [Tribolium castaneum]>gi|270003731|gb|EFA00179.1| hypothetical protein TcasGA2_TC003004 [Tribolium castaneum] 815929092 XM_003494688.2 345 2.55924e-178 PREDICTED: Bombus impatiens retinoblastoma-binding protein 5 homolog (LOC100746759), mRNA K14961 RBBP5, SWD1, CPS50 COMPASS component SWD1 http://www.genome.jp/dbget-bin/www_bget?ko:K14961 Q9VPH8 1792 1.5e-198 Retinoblastoma-binding protein 5 homolog OS=Drosophila melanogaster GN=Rbbp5 PE=1 SV=2 PF00400//PF01459 WD domain, G-beta repeat//Eukaryotic porin GO:0055085 transmembrane transport GO:0005515 protein binding GO:0005741 mitochondrial outer membrane KOG1273 WD40 repeat protein Cluster-8309.18818 BP_3 298.00 13.13 1386 642920988 XP_974589.2 1430 1.4e-155 PREDICTED: ATPase ASNA1 homolog [Tribolium castaneum] 641655703 XM_001943502.3 104 9.51886e-45 PREDICTED: Acyrthosiphon pisum ATPase ASNA1 homolog (LOC100162894), mRNA K01551 arsA, ASNA1 arsenite-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01551 Q16MG9 1279 1.8e-139 ATPase ASNA1 homolog OS=Aedes aegypti GN=AAEL011136 PE=3 SV=1 PF02562//PF06414//PF00448 PhoH-like protein//Zeta toxin//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0005524//GO:0016301 GTP binding//ATP binding//kinase activity -- -- KOG2825 Putative arsenite-translocating ATPase Cluster-8309.18823 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18826 BP_3 22.07 0.58 2118 642930369 XP_008196368.1 2144 3.4e-238 PREDICTED: dymeclin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q293C2 1308 1.2e-142 Dymeclin OS=Drosophila pseudoobscura pseudoobscura GN=GA20914 PE=3 SV=1 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG2225 Proteins containing regions of low-complexity Cluster-8309.1883 BP_3 10.00 0.38 1561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00969 Class II histocompatibility antigen, beta domain GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane -- -- Cluster-8309.18831 BP_3 45.32 0.32 7130 91086723 XP_970869.1 1565 1.6e-170 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 1.88752e-08 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 840 7.5e-88 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF08022//PF02535 FAD-binding domain//ZIP Zinc transporter GO:0055114//GO:0055085//GO:0030001 oxidation-reduction process//transmembrane transport//metal ion transport GO:0016491//GO:0046873 oxidoreductase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.18832 BP_3 67.58 0.44 7707 91086723 XP_970869.1 796 2.5e-81 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 2.04106e-08 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 560 2.4e-55 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF02535//PF08022//PF04893 ZIP Zinc transporter//FAD-binding domain//Yip1 domain GO:0055085//GO:0030001//GO:0055114 transmembrane transport//metal ion transport//oxidation-reduction process GO:0046873//GO:0016491 metal ion transmembrane transporter activity//oxidoreductase activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.18833 BP_3 10.00 3.37 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18835 BP_3 29.00 0.76 2139 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18839 BP_3 6.04 0.33 1186 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18840 BP_3 17.00 2.48 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18842 BP_3 728.78 5.33 6888 642918714 XP_008191551.1 3440 0.0e+00 PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|642918716|ref|XP_008191552.1| PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|270005665|gb|EFA02113.1| hypothetical protein TcasGA2_TC007759 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 Q13393 1678 4.9e-185 Phospholipase D1 OS=Homo sapiens GN=PLD1 PE=1 SV=1 PF00614//PF00787//PF02399 Phospholipase D Active site motif//PX domain//Origin of replication binding protein GO:0006260//GO:0007154//GO:0008152 DNA replication//cell communication//metabolic process GO:0003688//GO:0003824//GO:0005524//GO:0035091 DNA replication origin binding//catalytic activity//ATP binding//phosphatidylinositol binding GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.18845 BP_3 20.00 0.39 2735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18846 BP_3 6.22 0.38 1079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1885 BP_3 2.00 1.10 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03141 Putative S-adenosyl-L-methionine-dependent methyltransferase -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.18850 BP_3 6.56 0.38 1131 642936711 XP_008200418.1 767 8.4e-79 PREDICTED: eukaryotic initiation factor 4E isoform X1 [Tribolium castaneum] -- -- -- -- -- K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 Q8BMB3 381 2.0e-35 Eukaryotic translation initiation factor 4E type 2 OS=Mus musculus GN=Eif4e2 PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.18853 BP_3 37.38 3.82 763 478256534 ENN76718.1 311 4.3e-26 hypothetical protein YQE_06783, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NZL3 220 6.3e-17 Zinc finger protein 224 OS=Homo sapiens GN=ZNF224 PE=1 SV=3 PF00096//PF13465//PF00450//PF00628//PF02892//PF16622//PF01428 Zinc finger, C2H2 type//Zinc-finger double domain//Serine carboxypeptidase//PHD-finger//BED zinc finger//zinc-finger C2H2-type//AN1-like Zinc finger GO:0006508 proteolysis GO:0003677//GO:0008270//GO:0005515//GO:0004185//GO:0046872 DNA binding//zinc ion binding//protein binding//serine-type carboxypeptidase activity//metal ion binding -- -- -- -- Cluster-8309.18856 BP_3 15.80 0.40 2212 642922794 XP_008193328.1 530 5.0e-51 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 286 4.1e-24 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 PF00418 Tau and MAP protein, tubulin-binding repeat -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex -- -- Cluster-8309.18857 BP_3 38.52 0.84 2501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769//PF03603 Divalent cation transporter//DNA polymerase III psi subunit GO:0006812//GO:0006260 cation transport//DNA replication GO:0003887//GO:0008324//GO:0008408 DNA-directed DNA polymerase activity//cation transmembrane transporter activity//3'-5' exonuclease activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.18861 BP_3 248.19 4.03 3260 91087279 XP_975547.1 1604 2.1e-175 PREDICTED: DNA repair protein complementing XP-C cells homolog [Tribolium castaneum]>gi|270009546|gb|EFA05994.1| hypothetical protein TcasGA2_TC008820 [Tribolium castaneum] -- -- -- -- -- K10838 XPC xeroderma pigmentosum group C-complementing protein http://www.genome.jp/dbget-bin/www_bget?ko:K10838 Q24595 1174 6.4e-127 DNA repair protein complementing XP-C cells homolog OS=Drosophila melanogaster GN=mus210 PE=1 SV=2 PF10404//PF10403//PF10405 Rad4 beta-hairpin domain 2//Rad4 beta-hairpin domain 1//Rad4 beta-hairpin domain 3 -- -- GO:0003677 DNA binding -- -- KOG2179 Nucleotide excision repair complex XPC-HR23B, subunit XPC/DPB11 Cluster-8309.18863 BP_3 3.00 0.97 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18865 BP_3 27.81 0.51 2926 189240517 XP_001812287.1 856 1.0e-88 PREDICTED: uncharacterized protein LOC659874 isoform X1 [Tribolium castaneum]>gi|270012592|gb|EFA09040.1| hypothetical protein TcasGA2_TC006753 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15339 Acrosome formation-associated factor GO:0007342//GO:0060478//GO:0006897 fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis//endocytosis -- -- GO:0005886 plasma membrane -- -- Cluster-8309.18866 BP_3 4.00 0.51 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18869 BP_3 580.74 58.77 768 91079352 XP_969834.1 637 6.8e-64 PREDICTED: mediator of RNA polymerase II transcription subunit 10 [Tribolium castaneum]>gi|270004361|gb|EFA00809.1| hypothetical protein TcasGA2_TC003696 [Tribolium castaneum] -- -- -- -- -- K15151 MED10, NUT2 mediator of RNA polymerase II transcription subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K15151 Q16G71 536 1.4e-53 Mediator of RNA polymerase II transcription subunit 10 OS=Aedes aegypti GN=MED10 PE=3 SV=1 PF09748//PF05531 Transcription factor subunit Med10 of Mediator complex//Nucleopolyhedrovirus P10 protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0019028 mediator complex//viral capsid KOG3046 Transcription factor, subunit of SRB subcomplex of RNA polymerase II Cluster-8309.1887 BP_3 2.00 0.79 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18871 BP_3 82.10 2.03 2242 307186601 EFN72115.1 424 1.0e-38 hypothetical protein EAG_00326, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02160 Cauliflower mosaic virus peptidase (A3) GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.18876 BP_3 13.72 0.54 1525 478256734 ENN76915.1 1624 4.8e-178 hypothetical protein YQE_06562, partial [Dendroctonus ponderosae]>gi|546672598|gb|ERL84399.1| hypothetical protein D910_01832 [Dendroctonus ponderosae] 807037650 XM_004533743.2 52 8.46753e-16 PREDICTED: Ceratitis capitata tyrosine--tRNA ligase, mitochondrial (LOC101458353), mRNA K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q9W107 1304 2.5e-142 Tyrosine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-tyr-m PE=2 SV=1 PF01479//PF00579 S4 domain//tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0003723//GO:0005524//GO:0000166//GO:0004812 RNA binding//ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG2623 Tyrosyl-tRNA synthetase Cluster-8309.18877 BP_3 12.00 1.66 641 478253101 ENN73474.1 241 4.7e-18 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1888 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18882 BP_3 7.93 2.55 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18885 BP_3 10.03 0.40 1500 861599125 KMQ83546.1 293 1.0e-23 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18886 BP_3 13.05 0.51 1525 270015247 EFA11695.1 384 2.9e-34 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-8309.18887 BP_3 25.92 1.00 1537 861605932 KMQ84424.1 396 1.2e-35 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.18888 BP_3 28.68 0.50 3044 270014292 EFA10740.1 1059 3.1e-112 star [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42519 476 5.2e-46 Protein Star OS=Drosophila melanogaster GN=S PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1889 BP_3 6.92 0.60 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18892 BP_3 27.56 0.74 2096 659099915 AID60336.1 596 1.1e-58 trypsin-2 [Nilaparvata lugens]>gi|659100019|gb|AID60340.1| trypsin-6 [Nilaparvata lugens] 584066431 XM_006753576.1 36 9.18331e-07 PREDICTED: Myotis davidii kallikrein-related peptidase 11 (KLK11), transcript variant X2, mRNA K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 Q8MQS8 416 3.2e-39 Venom serine protease 34 OS=Apis mellifera PE=2 SV=1 PF00089//PF16622 Trypsin//zinc-finger C2H2-type GO:0006508 proteolysis GO:0046872//GO:0004252 metal ion binding//serine-type endopeptidase activity -- -- -- -- Cluster-8309.18898 BP_3 46.00 2.92 1052 641666417 XP_008183728.1 316 1.6e-26 PREDICTED: transcription factor Adf-1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P05552 133 1.1e-06 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 PF00485//PF01097//PF02944 Phosphoribulokinase / Uridine kinase family//Arthropod defensin//BESS motif GO:0008152//GO:0006952 metabolic process//defense response GO:0003677//GO:0016301//GO:0005524 DNA binding//kinase activity//ATP binding -- -- -- -- Cluster-8309.18899 BP_3 3.00 0.52 571 478253961 ENN74253.1 317 6.5e-27 hypothetical protein YQE_09225, partial [Dendroctonus ponderosae]>gi|546674834|gb|ERL86120.1| hypothetical protein D910_03534 [Dendroctonus ponderosae] -- -- -- -- -- K00720 UGCG ceramide glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00720 O88693 221 3.6e-17 Ceramide glucosyltransferase OS=Mus musculus GN=Ugcg PE=1 SV=1 PF13506 Glycosyl transferase family 21 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2547 Ceramide glucosyltransferase Cluster-8309.18901 BP_3 77.20 1.97 2176 642922849 XP_008200420.1 826 2.3e-85 PREDICTED: C-type lectin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18902 BP_3 7.00 1.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18904 BP_3 209.00 15.01 963 642935480 XP_008198027.1 373 3.5e-33 PREDICTED: filament-like plant protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03039//PF00715 Interleukin-12 alpha subunit//Interleukin 2 GO:0006955//GO:0040007//GO:0007165//GO:0008283 immune response//growth//signal transduction//cell proliferation GO:0005134//GO:0005143//GO:0008083 interleukin-2 receptor binding//interleukin-12 receptor binding//growth factor activity GO:0005576//GO:0005893//GO:0042022 extracellular region//interleukin-2 receptor complex//interleukin-12 receptor complex -- -- Cluster-8309.18907 BP_3 3.00 0.36 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18908 BP_3 16.42 1.57 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1892 BP_3 39.78 2.22 1156 270002767 EEZ99214.1 1157 5.2e-124 serine protease P12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 424 2.1e-40 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.18920 BP_3 1.00 3.30 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18922 BP_3 3.00 1.45 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18923 BP_3 199.87 4.68 2349 642930369 XP_008196368.1 2381 1.2e-265 PREDICTED: dymeclin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q293C2 1460 3.2e-160 Dymeclin OS=Drosophila pseudoobscura pseudoobscura GN=GA20914 PE=3 SV=1 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG2225 Proteins containing regions of low-complexity Cluster-8309.18927 BP_3 7.98 0.40 1262 641672407 XP_008185929.1 165 6.0e-09 PREDICTED: uncharacterized protein LOC103310210 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.18928 BP_3 12.31 0.39 1795 91079696 XP_968351.1 945 3.1e-99 PREDICTED: rRNA 2'-O-methyltransferase fibrillarin [Tribolium castaneum]>gi|270003342|gb|EEZ99789.1| hypothetical protein TcasGA2_TC002569 [Tribolium castaneum] 746845440 XM_011054705.1 104 1.24006e-44 PREDICTED: Acromyrmex echinatior rRNA 2'-O-methyltransferase fibrillarin (LOC105145259), mRNA K14563 NOP1, FBL rRNA 2'-O-methyltransferase fibrillarin http://www.genome.jp/dbget-bin/www_bget?ko:K14563 Q8I1F4 935 1.8e-99 rRNA 2'-O-methyltransferase fibrillarin OS=Drosophila erecta GN=Fib PE=3 SV=1 PF01269 Fibrillarin GO:0032259//GO:0008033//GO:0006364 methylation//tRNA processing//rRNA processing GO:0003723//GO:0008168 RNA binding//methyltransferase activity -- -- KOG1596 Fibrillarin and related nucleolar RNA-binding proteins Cluster-8309.18929 BP_3 11.78 0.78 1016 642922922 XP_971943.2 770 3.4e-79 PREDICTED: coiled-coil domain-containing protein 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T312 581 1.2e-58 Coiled-coil domain-containing protein 25 OS=Danio rerio GN=ccdc25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3272 Predicted coiled-coil protein Cluster-8309.18930 BP_3 403.63 15.79 1524 189237437 XP_001815618.1 890 6.2e-93 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWP5 346 3.1e-31 Alpha-tocopherol transfer protein OS=Mus musculus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18931 BP_3 44.91 0.73 3243 189237437 XP_001815618.1 722 4.0e-73 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWP5 313 4.4e-27 Alpha-tocopherol transfer protein OS=Mus musculus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18932 BP_3 11.00 0.50 1355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18935 BP_3 147.71 1.18 6335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07928//PF08047 Vps54-like protein//Histidine operon leader peptide GO:0042147//GO:0000105 retrograde transport, endosome to Golgi//histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.18936 BP_3 33.00 0.82 2229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18938 BP_3 73.36 1.56 2554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18943 BP_3 35.74 0.46 4006 478250074 ENN70580.1 978 1.0e-102 hypothetical protein YQE_12755, partial [Dendroctonus ponderosae]>gi|546672658|gb|ERL84454.1| hypothetical protein D910_01886 [Dendroctonus ponderosae] 642933290 XM_008199137.1 98 6.05293e-41 PREDICTED: Tribolium castaneum cytochrome b5 reductase 4 (LOC656620), transcript variant X2, mRNA K00326 E1.6.2.2 cytochrome-b5 reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00326 Q68EJ0 395 1.7e-36 Cytochrome b5 reductase 4 OS=Rattus norvegicus GN=Cyb5r4 PE=1 SV=2 PF00175//PF02294//PF08030 Oxidoreductase NAD-binding domain//7kD DNA-binding domain//Ferric reductase NAD binding domain GO:0055114//GO:0051252 oxidation-reduction process//regulation of RNA metabolic process GO:0016491//GO:0004521//GO:0003677 oxidoreductase activity//endoribonuclease activity//DNA binding -- -- KOG0536 Flavohemoprotein b5+b5R Cluster-8309.18945 BP_3 8.00 0.43 1187 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18947 BP_3 16.55 0.93 1150 642936275 XP_967688.3 854 7.0e-89 PREDICTED: protein tincar isoform X1 [Tribolium castaneum]>gi|642936277|ref|XP_008198379.1| PREDICTED: protein tincar isoform X1 [Tribolium castaneum]>gi|642936279|ref|XP_008198380.1| PREDICTED: protein tincar isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B91 316 7.0e-28 Protein tincar OS=Drosophila melanogaster GN=tinc PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18948 BP_3 65.44 0.67 4984 642936285 XP_008198383.1 2209 2.3e-245 PREDICTED: protein tincar isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B91 453 3.9e-43 Protein tincar OS=Drosophila melanogaster GN=tinc PE=2 SV=1 PF00599//PF10384 Influenza Matrix protein (M2)//Centromere protein Scm3 GO:0015992 proton transport GO:0042393//GO:0015078 histone binding//hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036//GO:0005634 host cell membrane//virion membrane//nucleus -- -- Cluster-8309.18954 BP_3 24.77 0.60 2297 91094355 XP_970090.1 787 8.2e-81 PREDICTED: ATM interactor [Tribolium castaneum]>gi|270014934|gb|EFA11382.1| hypothetical protein TcasGA2_TC011542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9S1 196 1.1e-13 ATM interactor OS=Mus musculus GN=Atmin PE=2 SV=2 PF00096//PF16622//PF13912 Zinc finger, C2H2 type//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.18957 BP_3 8.80 0.94 744 478252250 ENN72678.1 526 4.9e-51 hypothetical protein YQE_10776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1896 BP_3 2.00 0.54 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18960 BP_3 194.83 4.13 2567 189235643 XP_967729.2 1570 1.5e-171 PREDICTED: metallophosphoesterase 1 [Tribolium castaneum]>gi|270004406|gb|EFA00854.1| hypothetical protein TcasGA2_TC003757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZK82 806 2.4e-84 Metallophosphoesterase 1 OS=Gallus gallus GN=MPPE1 PE=2 SV=1 PF00599//PF00149 Influenza Matrix protein (M2)//Calcineurin-like phosphoesterase GO:0015992 proton transport GO:0016787//GO:0015078 hydrolase activity//hydrogen ion transmembrane transporter activity GO:0055036//GO:0033644 virion membrane//host cell membrane KOG3662 Cell division control protein/predicted DNA repair exonuclease Cluster-8309.18967 BP_3 30.53 2.02 1019 91085583 XP_968374.1 649 3.7e-65 PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|642926992|ref|XP_008195095.1| PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|270010071|gb|EFA06519.1| hypothetical protein TcasGA2_TC009422 [Tribolium castaneum] -- -- -- -- -- K06693 PSMD9 26S proteasome non-ATPase regulatory subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06693 Q9WTV5 456 3.6e-44 26S proteasome non-ATPase regulatory subunit 9 OS=Rattus norvegicus GN=Psmd9 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3129 26S proteasome regulatory complex, subunit PSMD9 Cluster-8309.18969 BP_3 11.16 0.41 1593 91082001 XP_969328.1 520 5.2e-50 PREDICTED: vacuolar protein sorting-associated protein 37A [Tribolium castaneum]>gi|270007313|gb|EFA03761.1| hypothetical protein TcasGA2_TC013872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NEZ2 190 4.0e-13 Vacuolar protein sorting-associated protein 37A OS=Homo sapiens GN=VPS37A PE=1 SV=1 PF09204//PF06156 Bacterial self-protective colicin-like immunity//Protein of unknown function (DUF972) GO:0030153//GO:0006955//GO:0006260 bacteriocin immunity//immune response//DNA replication GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex KOG3270 Uncharacterized conserved protein Cluster-8309.18973 BP_3 17.00 2.62 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18977 BP_3 25.00 0.33 3938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18984 BP_3 32.60 0.51 3374 270009523 EFA05971.1 243 1.5e-17 hypothetical protein TcasGA2_TC008793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18985 BP_3 856.30 14.13 3213 270009523 EFA05971.1 362 2.2e-31 hypothetical protein TcasGA2_TC008793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18986 BP_3 548.00 22.46 1468 270016714 EFA13160.1 144 1.9e-06 hypothetical protein TcasGA2_TC015964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05369//PF08777//PF00076 Monomethylamine methyltransferase MtmB//RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0032259 methylation GO:0003676//GO:0008168//GO:0003723 nucleic acid binding//methyltransferase activity//RNA binding -- -- -- -- Cluster-8309.18990 BP_3 42.66 0.39 5588 642915691 XP_008190761.1 2700 3.0e-302 PREDICTED: cyclic nucleotide-gated cation channel subunit A [Tribolium castaneum] 170060746 XM_001865903.1 397 0 Culex quinquefasciatus cyclic-nucleotide-gated cation channel, mRNA K04950 CNGA3 cyclic nucleotide gated channel alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04950 Q24278 2171 2.7e-242 Cyclic nucleotide-gated cation channel subunit A OS=Drosophila melanogaster GN=CngA PE=2 SV=2 PF07926//PF05929//PF01105//PF00520 TPR/MLP1/MLP2-like protein//Phage capsid scaffolding protein (GPO) serine peptidase//emp24/gp25L/p24 family/GOLD//Ion transport protein GO:0006606//GO:0006811//GO:0019069//GO:0055085//GO:0006810 protein import into nucleus//ion transport//viral capsid assembly//transmembrane transport//transport GO:0005216 ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.18992 BP_3 3632.09 52.93 3599 270008878 EFA05326.1 1127 4.9e-120 hypothetical protein TcasGA2_TC015490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 347 5.6e-31 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF15957//PF03067//PF04277//PF00089 Commissureless//Chitin binding domain//Oxaloacetate decarboxylase, gamma chain//Trypsin GO:0006814//GO:0006508//GO:0071436//GO:0006090//GO:0007411//GO:0006525//GO:0006560 sodium ion transport//proteolysis//sodium ion export//pyruvate metabolic process//axon guidance//arginine metabolic process//proline metabolic process GO:0015081//GO:0004252//GO:0008948 sodium ion transmembrane transporter activity//serine-type endopeptidase activity//oxaloacetate decarboxylase activity GO:0016020//GO:0019028 membrane//viral capsid -- -- Cluster-8309.18998 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.190 BP_3 5.00 1.23 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1900 BP_3 30.88 0.43 3772 642933871 XP_974162.3 1216 2.4e-130 PREDICTED: uncharacterized protein LOC663002 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q6PA23 356 5.3e-32 Lipase member H-A OS=Xenopus laevis GN=liph-a PE=2 SV=1 PF01674//PF08476 Lipase (class 2)//Viral D10 N-terminal -- -- GO:0016791//GO:0016787 phosphatase activity//hydrolase activity -- -- -- -- Cluster-8309.19002 BP_3 4.00 1.27 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19003 BP_3 140.66 0.73 9539 91093683 XP_970017.1 878 9.6e-91 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q41745 434 1.2e-40 1-acyl-sn-glycerol-3-phosphate acyltransferase PLS1 OS=Zea mays GN=PLS1 PE=2 SV=1 PF01553//PF04136//PF01395 Acyltransferase//Sec34-like family//PBP/GOBP family GO:0008152//GO:0006886 metabolic process//intracellular protein transport GO:0005549//GO:0016746 odorant binding//transferase activity, transferring acyl groups GO:0016020//GO:0005801 membrane//cis-Golgi network KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.19004 BP_3 210.50 5.60 2103 642912946 XP_008201319.1 2312 1.1e-257 PREDICTED: integrator complex subunit 10 [Tribolium castaneum] -- -- -- -- -- K13147 INTS10 integrator complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13147 Q6TNU3 462 1.5e-44 Integrator complex subunit 10 OS=Danio rerio GN=ints10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19009 BP_3 241.66 22.61 807 91076710 XP_972261.1 739 1.1e-75 PREDICTED: ER membrane protein complex subunit 10 [Tribolium castaneum]>gi|270001865|gb|EEZ98312.1| hypothetical protein TcasGA2_TC000766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5D8P8 295 1.3e-25 ER membrane protein complex subunit 10 OS=Xenopus laevis GN=emc10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4827 Uncharacterized conserved protein Cluster-8309.1901 BP_3 13.14 1.22 810 478259247 ENN79149.1 348 2.3e-30 hypothetical protein YQE_04335, partial [Dendroctonus ponderosae] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q32PY2 185 7.7e-13 Lipase member H OS=Rattus norvegicus GN=Liph PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19010 BP_3 17574.00 527.34 1898 642920647 XP_008192503.1 218 6.5e-15 PREDICTED: AP2-associated protein kinase 1-like [Tribolium castaneum]>gi|270006082|gb|EFA02530.1| hypothetical protein TcasGA2_TC008235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19012 BP_3 315.92 4.78 3477 91094511 XP_971832.1 1219 1.0e-130 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.52879e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 O35737 650 3.9e-66 Heterogeneous nuclear ribonucleoprotein H OS=Mus musculus GN=Hnrnph1 PE=1 SV=3 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:1901363//GO:0003723//GO:0097159 nucleic acid binding//heterocyclic compound binding//RNA binding//organic cyclic compound binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.19013 BP_3 9.00 0.44 1269 91085531 XP_972280.1 1352 1.4e-146 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q5RBM6 1117 1.0e-120 Beta-ureidopropionase OS=Pongo abelii GN=UPB1 PE=2 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0808 Carbon-nitrogen hydrolase Cluster-8309.19019 BP_3 118.00 10.21 849 270008452 EFA04900.1 325 1.1e-27 hypothetical protein TcasGA2_TC014964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977//PF02050//PF02216//PF17060 Septum formation initiator//Flagellar FliJ protein//B domain//Monopolar spindle protein 2 GO:0030474//GO:0071973//GO:0006935//GO:0009405//GO:0007049//GO:0071988 spindle pole body duplication//bacterial-type flagellum-dependent cell motility//chemotaxis//pathogenesis//cell cycle//protein localization to spindle pole body GO:0019865//GO:0003774 immunoglobulin binding//motor activity GO:0019814//GO:0016020//GO:0009288 immunoglobulin complex//membrane//bacterial-type flagellum -- -- Cluster-8309.1902 BP_3 24.82 0.33 3909 642933871 XP_974162.3 1216 2.5e-130 PREDICTED: uncharacterized protein LOC663002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VBX1 357 4.2e-32 Endothelial lipase OS=Rattus norvegicus GN=Lipg PE=2 SV=2 PF01674 Lipase (class 2) -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.19024 BP_3 76.06 4.76 1062 642931615 XP_008196657.1 290 1.6e-23 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Tribolium castaneum] 807033681 XM_004529871.2 62 1.61336e-21 PREDICTED: Ceratitis capitata DNA-directed RNA polymerases I, II, and III subunit RPABC4 (LOC101457024), mRNA K03009 RPB12, POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 http://www.genome.jp/dbget-bin/www_bget?ko:K03009 Q3ZBC0 236 1.2e-18 DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Bos taurus GN=POLR2K PE=3 SV=1 PF03604//PF01155 DNA directed RNA polymerase, 7 kDa subunit//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006206//GO:0006144//GO:0006464//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//cellular protein modification process//transcription, DNA-templated GO:0016151//GO:0003899//GO:0003677 nickel cation binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG3507 DNA-directed RNA polymerase, subunit RPB7.0 Cluster-8309.19030 BP_3 36.21 0.42 4436 642914452 XP_008201682.1 1063 1.6e-112 PREDICTED: GRAM domain-containing protein 1B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80TI0 605 8.3e-61 GRAM domain-containing protein 1B OS=Mus musculus GN=Gramd1b PE=2 SV=2 PF00616 GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity -- -- -- -- KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.19034 BP_3 2.00 0.45 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00096 BED zinc finger//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.19035 BP_3 39.91 0.56 3719 642911734 XP_008200718.1 1166 1.5e-124 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC660336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PD21 334 1.9e-29 SH2 domain-containing adapter protein B OS=Mus musculus GN=Shb PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19036 BP_3 23.63 0.60 2194 478256367 ENN76557.1 2591 5.1e-290 hypothetical protein YQE_07008, partial [Dendroctonus ponderosae] -- -- -- -- -- K10455 KLHL18 kelch-like protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K10455 O94889 1471 1.6e-161 Kelch-like protein 18 OS=Homo sapiens GN=KLHL18 PE=1 SV=3 PF00651//PF07646//PF01344 BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.1904 BP_3 132.21 1.60 4267 642914827 XP_008194958.1 152 6.6e-07 PREDICTED: lipase member H-B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19049 BP_3 8.00 0.43 1196 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1905 BP_3 98.00 7.63 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19052 BP_3 563.19 10.77 2813 478250729 ENN71221.1 2624 9.8e-294 hypothetical protein YQE_12149, partial [Dendroctonus ponderosae] -- -- -- -- -- K00784 rnz ribonuclease Z http://www.genome.jp/dbget-bin/www_bget?ko:K00784 Q8MKW7 1185 2.9e-128 Ribonuclease Z, mitochondrial OS=Drosophila melanogaster GN=JhI-1 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG2121 Predicted metal-dependent hydrolase (beta-lactamase superfamily) Cluster-8309.19053 BP_3 35.81 0.67 2863 478250729 ENN71221.1 1928 5.1e-213 hypothetical protein YQE_12149, partial [Dendroctonus ponderosae] -- -- -- -- -- K00784 rnz ribonuclease Z http://www.genome.jp/dbget-bin/www_bget?ko:K00784 Q8MKW7 713 1.6e-73 Ribonuclease Z, mitochondrial OS=Drosophila melanogaster GN=JhI-1 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG2121 Predicted metal-dependent hydrolase (beta-lactamase superfamily) Cluster-8309.19055 BP_3 39.15 0.62 3340 189239531 XP_975588.2 1305 1.0e-140 PREDICTED: myb-related protein B isoform X1 [Tribolium castaneum] 817200908 XM_012420764.1 89 5.07326e-36 PREDICTED: Orussus abietinus myb-related protein B (LOC105697441), transcript variant X2, mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 P01103 467 6.3e-45 Transcriptional activator Myb OS=Gallus gallus GN=MYB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0048 Transcription factor, Myb superfamily Cluster-8309.19058 BP_3 64.00 0.81 4091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19059 BP_3 107.00 1.19 4638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01095 Pectinesterase GO:0005985//GO:0005982//GO:0042545 sucrose metabolic process//starch metabolic process//cell wall modification GO:0030599 pectinesterase activity GO:0005618 cell wall -- -- Cluster-8309.19061 BP_3 32.00 0.67 2585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19062 BP_3 8.92 1.14 670 642929063 XP_008195676.1 485 2.5e-46 PREDICTED: flocculation protein FLO11 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19063 BP_3 74.80 0.76 5047 642920481 XP_008192369.1 1772 1.1e-194 PREDICTED: liprin-beta-1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86W92 885 3.2e-93 Liprin-beta-1 OS=Homo sapiens GN=PPFIBP1 PE=1 SV=2 PF07647//PF00536//PF02198 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain -- -- GO:0005515//GO:0043565 protein binding//sequence-specific DNA binding GO:0005634 nucleus KOG0249 LAR-interacting protein and related proteins Cluster-8309.19064 BP_3 11.00 1.03 804 13898841 AAK48894.1 569 5.5e-56 CUB-serine protease [Panulirus argus] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 Q05319 484 1.6e-47 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19065 BP_3 14.00 1.63 706 13898841 AAK48894.1 161 9.8e-09 CUB-serine protease [Panulirus argus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19069 BP_3 7.41 0.32 1411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02388 FemAB family GO:0009252 peptidoglycan biosynthetic process GO:0016755 transferase activity, transferring amino-acyl groups -- -- -- -- Cluster-8309.1907 BP_3 26.98 0.33 4263 642919551 XP_008191919.1 1553 2.3e-169 PREDICTED: synaptotagmin-12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IV01 512 4.9e-50 Synaptotagmin-12 OS=Homo sapiens GN=SYT12 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.19070 BP_3 2.00 1.42 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19073 BP_3 2.00 0.48 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19075 BP_3 21.57 0.84 1529 861587829 KMQ82562.1 454 2.3e-42 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] 795022879 XM_012005361.1 136 1.71229e-62 PREDICTED: Vollenhovia emeryi uncharacterized LOC105557942 (LOC105557942), transcript variant X1, mRNA -- -- -- -- Q7JQ07 160 1.1e-09 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF13404//PF01047//PF04545//PF13545 AsnC-type helix-turn-helix domain//MarR family//Sigma-70, region 4//Crp-like helix-turn-helix domain GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0043565//GO:0003700 DNA binding//sigma factor activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.19079 BP_3 122.64 0.98 6348 642927278 XP_008195204.1 487 1.4e-45 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19080 BP_3 24.28 0.64 2130 755977116 XP_011308172.1 2105 1.1e-233 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X7 [Fopius arisanus] 759080223 XM_011351646.1 259 1.01179e-130 PREDICTED: Cerapachys biroi uncharacterized LOC105286595 (LOC105286595), transcript variant X3, mRNA K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 P70182 1208 4.8e-131 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Mus musculus GN=Pip5k1a PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.19084 BP_3 11.00 0.32 1971 642917912 XP_008191379.1 993 9.2e-105 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQM8 481 8.8e-47 UDP-glucuronosyltransferase 1-7C OS=Mus musculus GN=Ugt1a7c PE=2 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.19086 BP_3 122.08 2.10 3095 91080681 XP_975202.1 1354 2.0e-146 PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|642919555|ref|XP_008191921.1| PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|270005851|gb|EFA02299.1| hypothetical protein TcasGA2_TC007964 [Tribolium castaneum] 665800505 XM_008549999.1 212 1.97926e-104 PREDICTED: Microplitis demolitor CCR4-NOT transcription complex subunit 7 (LOC103571729), transcript variant X3, mRNA K12581 CNOT7_8, CAF1, POP2 CCR4-NOT transcription complex subunit 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12581 Q9UIV1 1046 4.2e-112 CCR4-NOT transcription complex subunit 7 OS=Homo sapiens GN=CNOT7 PE=1 SV=3 PF04857//PF13482 CAF1 family ribonuclease//RNase_H superfamily -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG0304 mRNA deadenylase subunit Cluster-8309.19087 BP_3 88.00 3.19 1620 478257475 ENN77631.1 1606 6.2e-176 hypothetical protein YQE_05925, partial [Dendroctonus ponderosae]>gi|546679869|gb|ERL90257.1| hypothetical protein D910_07609 [Dendroctonus ponderosae] -- -- -- -- -- K15276 SLC35B2, PAPST1 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 http://www.genome.jp/dbget-bin/www_bget?ko:K15276 Q9VEI3 1083 1.1e-116 Adenosine 3'-phospho 5'-phosphosulfate transporter 1 OS=Drosophila melanogaster GN=sll PE=1 SV=1 PF00892//PF15220//PF08449 EamA-like transporter family//Hypoxia-inducible lipid droplet-associated//UAA transporter family GO:0008284//GO:0055085//GO:0010884//GO:0001819 positive regulation of cell proliferation//transmembrane transport//positive regulation of lipid storage//positive regulation of cytokine production -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1581 UDP-galactose transporter related protein Cluster-8309.19088 BP_3 10.00 3.37 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1909 BP_3 4.00 0.57 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19092 BP_3 7.78 0.32 1468 282400160 NP_001164203.1 2146 1.4e-238 cannonball [Tribolium castaneum]>gi|270008125|gb|EFA04573.1| cannonball [Tribolium castaneum] 242007793 XM_002424662.1 181 1.5853e-87 Pediculus humanus corporis transcription initiation factor TFIID subunit, putative, mRNA K03130 TAF5 transcription initiation factor TFIID subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03130 P49846 1404 6.2e-154 Transcription initiation factor TFIID subunit 5 OS=Drosophila melanogaster GN=Taf5 PE=1 SV=1 PF04494//PF00400//PF00039 WD40 associated region in TFIID subunit, NTD2 domain//WD domain, G-beta repeat//Fibronectin type I domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005576//GO:0005634 extracellular region//nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.19096 BP_3 137.00 3.91 1982 270011395 EFA07843.1 1948 1.7e-215 hypothetical protein TcasGA2_TC005413 [Tribolium castaneum] 780679440 XM_011698908.1 35 3.12021e-06 PREDICTED: Wasmannia auropunctata beta-glucuronidase (LOC105455522), transcript variant X8, mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P12265 1206 7.6e-131 Beta-glucuronidase OS=Mus musculus GN=Gusb PE=2 SV=2 PF02836//PF00703//PF02837//PF00150 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.1910 BP_3 5.00 0.49 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02963 Restriction endonuclease EcoRI GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036//GO:0000287 DNA binding//Type II site-specific deoxyribonuclease activity//magnesium ion binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.19101 BP_3 175.00 2.70 3410 642930609 XP_008193909.1 1545 1.6e-168 PREDICTED: GPI ethanolamine phosphate transferase 2 [Tribolium castaneum] -- -- -- -- -- K05310 GPI7 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05310 Q5H8A4 563 4.7e-56 GPI ethanolamine phosphate transferase 2 OS=Homo sapiens GN=PIGG PE=1 SV=1 PF00884//PF01676//PF01663 Sulfatase//Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0046872//GO:0003824//GO:0008484 metal ion binding//catalytic activity//sulfuric ester hydrolase activity -- -- KOG2125 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.19102 BP_3 123.77 0.84 7409 642921556 XP_008192422.1 4676 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TU53 2386 4.2e-267 Cubilin OS=Canis familiaris GN=CUBN PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.19103 BP_3 17.39 0.42 2311 546673408 ERL85020.1 278 8.7e-22 hypothetical protein D910_02443 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.19106 BP_3 1.00 0.40 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19108 BP_3 323.00 31.50 786 270011202 EFA07650.1 792 7.4e-82 hypothetical protein TcasGA2_TC030561 [Tribolium castaneum] -- -- -- -- -- K10428 DCTN6 dynactin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10428 Q5R7D8 469 8.7e-46 Dynactin subunit 6 OS=Pongo abelii GN=DCTN6 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- KOG4042 Dynactin subunit p27/WS-3, involved in transport of organelles along microtubules Cluster-8309.19109 BP_3 3.00 0.36 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.19113 BP_3 37.73 0.61 3261 642924596 XP_008194357.1 1534 2.8e-167 PREDICTED: putative ATP-dependent RNA helicase DHX33 [Tribolium castaneum]>gi|270006741|gb|EFA03189.1| hypothetical protein TcasGA2_TC013109 [Tribolium castaneum] -- -- -- -- -- K17820 DHX33 ATP-dependent RNA helicase DHX33 http://www.genome.jp/dbget-bin/www_bget?ko:K17820 Q9H6R0 907 5.9e-96 Putative ATP-dependent RNA helicase DHX33 OS=Homo sapiens GN=DHX33 PE=1 SV=2 PF07652//PF00437//PF00270//PF04851//PF04408//PF01637//PF00005 Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//Helicase associated domain (HA2)//Archaeal ATPase//ABC transporter GO:0006810//GO:0019079 transport//viral genome replication GO:0003676//GO:0016887//GO:0008026//GO:0005524//GO:0004386//GO:0016787//GO:0003677 nucleic acid binding//ATPase activity//ATP-dependent helicase activity//ATP binding//helicase activity//hydrolase activity//DNA binding -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.19115 BP_3 34.64 0.50 3606 642924596 XP_008194357.1 1539 8.2e-168 PREDICTED: putative ATP-dependent RNA helicase DHX33 [Tribolium castaneum]>gi|270006741|gb|EFA03189.1| hypothetical protein TcasGA2_TC013109 [Tribolium castaneum] -- -- -- -- -- K17820 DHX33 ATP-dependent RNA helicase DHX33 http://www.genome.jp/dbget-bin/www_bget?ko:K17820 Q9H6R0 906 8.5e-96 Putative ATP-dependent RNA helicase DHX33 OS=Homo sapiens GN=DHX33 PE=1 SV=2 PF07652//PF00270//PF00437//PF00005//PF04851//PF04408//PF01637 Flavivirus DEAD domain//DEAD/DEAH box helicase//Type II/IV secretion system protein//ABC transporter//Type III restriction enzyme, res subunit//Helicase associated domain (HA2)//Archaeal ATPase GO:0006810//GO:0019079 transport//viral genome replication GO:0008026//GO:0003677//GO:0016787//GO:0004386//GO:0005524//GO:0016887//GO:0003676 ATP-dependent helicase activity//DNA binding//hydrolase activity//helicase activity//ATP binding//ATPase activity//nucleic acid binding -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.19117 BP_3 68.23 1.74 2186 478260966 ENN80570.1 1116 5.6e-119 hypothetical protein YQE_03010, partial [Dendroctonus ponderosae]>gi|478264265|gb|ENN82194.1| hypothetical protein YQE_01430, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- L7YAI7 291 1.1e-24 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 PF13443 Cro/C1-type HTH DNA-binding domain -- -- GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.19118 BP_3 6.77 0.62 817 189236450 XP_001814629.1 291 9.6e-24 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|270005935|gb|EFA02383.1| hypothetical protein TcasGA2_TC008060 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13443 Cro/C1-type HTH DNA-binding domain -- -- GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.19121 BP_3 3.00 2.00 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19122 BP_3 51.30 0.78 3453 91084545 XP_973071.1 1808 5.0e-199 PREDICTED: tudor domain-containing protein 7 isoform X1 [Tribolium castaneum]>gi|270008665|gb|EFA05113.1| hypothetical protein TcasGA2_TC015214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.5e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 PF16622 zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.19128 BP_3 1.00 3.49 275 642914858 XP_008195062.1 166 1.0e-09 PREDICTED: uncharacterized protein LOC103313485 [Tribolium castaneum]>gi|270002307|gb|EEZ98754.1| hypothetical protein TcasGA2_TC001318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03033 Glycosyltransferase family 28 N-terminal domain GO:0030259//GO:0005975 lipid glycosylation//carbohydrate metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.19129 BP_3 205.45 3.53 3094 478255137 ENN75367.1 1626 5.7e-178 hypothetical protein YQE_08142, partial [Dendroctonus ponderosae] 642914874 XM_965920.3 58 8.02583e-19 PREDICTED: Tribolium castaneum protein inscuteable homolog (LOC659633), mRNA -- -- -- -- Q3HNM7 345 8.2e-31 Protein inscuteable homolog OS=Mus musculus GN=Insc PE=1 SV=2 PF00514//PF01066 Armadillo/beta-catenin-like repeat//CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0005515//GO:0016780 protein binding//phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane -- -- Cluster-8309.19130 BP_3 243.00 4.68 2792 270011683 EFA08131.1 627 3.6e-62 hypothetical protein TcasGA2_TC005735 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2IA00 300 1.2e-25 Sperm flagellar protein 2 OS=Sus scrofa GN=SPEF2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19131 BP_3 18.04 0.59 1770 91088651 XP_974484.1 1325 2.6e-143 PREDICTED: beta-1,4-galactosyltransferase 4 [Tribolium castaneum]>gi|270012269|gb|EFA08717.1| hypothetical protein TcasGA2_TC006388 [Tribolium castaneum] -- -- -- -- -- K07968 B4GALT3 beta-1,4-galactosyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07968 Q9GUM2 694 1.6e-71 Beta-1,4-N-acetylgalactosaminyltransferase bre-4 OS=Caenorhabditis elegans GN=bre-4 PE=1 SV=1 PF04421 Mss4 protein GO:0007264//GO:0043087 small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.19133 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19134 BP_3 181.46 5.77 1807 642931832 XP_008196749.1 1601 2.6e-175 PREDICTED: GPI inositol-deacylase [Tribolium castaneum]>gi|270011727|gb|EFA08175.1| hypothetical protein TcasGA2_TC005802 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q75T13 693 2.1e-71 GPI inositol-deacylase OS=Homo sapiens GN=PGAP1 PE=1 SV=1 PF07819//PF01764 PGAP1-like protein//Lipase (class 3) GO:0006505//GO:0009987//GO:0006629//GO:0006886 GPI anchor metabolic process//cellular process//lipid metabolic process//intracellular protein transport GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG3724 Negative regulator of COPII vesicle formation Cluster-8309.1914 BP_3 41.24 2.12 1229 91091230 XP_967536.1 738 2.1e-75 PREDICTED: uncharacterized protein LOC655883 [Tribolium castaneum]>gi|270013099|gb|EFA09547.1| hypothetical protein TcasGA2_TC011657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19141 BP_3 6.00 0.46 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19144 BP_3 19.00 0.80 1437 642926196 XP_008194825.1 753 4.5e-77 PREDICTED: uncharacterized protein LOC103313412 [Tribolium castaneum] 462343094 APGK01035499.1 48 1.33323e-13 Dendroctonus ponderosae Seq01035509, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02284 Cytochrome c oxidase subunit Va GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0045277 mitochondrial inner membrane//respiratory chain complex IV -- -- Cluster-8309.19145 BP_3 102.11 2.92 1976 751799211 XP_011209556.1 727 6.4e-74 PREDICTED: methyltransferase-like protein 23 [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q5U312 190 4.9e-13 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF13606//PF00887//PF00023//PF00076//PF06839//PF16367 Ankyrin repeat//Acyl CoA binding protein//Ankyrin repeat//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//GRF zinc finger//RNA recognition motif -- -- GO:0005515//GO:0008270//GO:0000062//GO:0003676 protein binding//zinc ion binding//fatty-acyl-CoA binding//nucleic acid binding -- -- -- -- Cluster-8309.19146 BP_3 167.50 3.94 2340 189241943 XP_971607.2 1924 1.2e-212 PREDICTED: uncharacterized aarF domain-containing protein kinase 1 [Tribolium castaneum]>gi|270015338|gb|EFA11786.1| hypothetical protein TcasGA2_TC008565 [Tribolium castaneum] -- -- -- -- -- K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 Q5ZMT7 1163 8.7e-126 Uncharacterized aarF domain-containing protein kinase 1 OS=Gallus gallus GN=ADCK1 PE=2 SV=1 PF09788//PF00069 Transmembrane protein 55A//Protein kinase domain GO:0046856//GO:0006468 phosphatidylinositol dephosphorylation//protein phosphorylation GO:0004672//GO:0034597//GO:0016772//GO:0005524 protein kinase activity//phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//transferase activity, transferring phosphorus-containing groups//ATP binding -- -- KOG1235 Predicted unusual protein kinase Cluster-8309.19150 BP_3 34.23 0.31 5686 478250173 ENN70676.1 1254 1.4e-134 hypothetical protein YQE_12621, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q88168 578 1.4e-57 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201//PF04111//PF03153 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Autophagy protein Apg6//Transcription factor IIA, alpha/beta subunit GO:0006914//GO:0006367//GO:0008152 autophagy//transcription initiation from RNA polymerase II promoter//metabolic process GO:0016758 transferase activity, transferring hexosyl groups GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.19153 BP_3 43.00 0.76 3022 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19156 BP_3 48.00 0.59 4233 478260373 ENN80120.1 3403 0.0e+00 hypothetical protein YQE_03479, partial [Dendroctonus ponderosae] -- -- -- -- -- K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 O35604 1867 3.7e-207 Niemann-Pick C1 protein OS=Mus musculus GN=Npc1 PE=1 SV=2 PF03176//PF02460 MMPL family//Patched family GO:0007165 signal transduction GO:0008158 hedgehog receptor activity GO:0016020 membrane KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.19157 BP_3 535.00 8.19 3441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19158 BP_3 111.69 1.30 4428 91082575 XP_966727.1 790 7.1e-81 PREDICTED: bifunctional arginine demethylase and lysyl-hydroxylase PSR isoform X1 [Tribolium castaneum] -- -- -- -- -- K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q6PFM0 581 5.0e-58 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Danio rerio GN=jmjd6 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain Cluster-8309.19159 BP_3 238.67 11.64 1280 642910728 XP_008193385.1 1731 1.6e-190 PREDICTED: bifunctional arginine demethylase and lysyl-hydroxylase PSR isoform X2 [Tribolium castaneum] 805820060 XM_003707252.2 125 1.85893e-56 PREDICTED: Megachile rotundata bifunctional arginine demethylase and lysyl-hydroxylase PSR (LOC100883265), transcript variant X1, mRNA K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q9VD28 1377 7.3e-151 Bifunctional arginine demethylase and lysyl-hydroxylase PSR OS=Drosophila melanogaster GN=PSR PE=2 SV=1 PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.19161 BP_3 118.73 1.03 5854 91090340 XP_967097.1 1862 4.7e-205 PREDICTED: hexosaminidase D [Tribolium castaneum]>gi|270013820|gb|EFA10268.1| hypothetical protein TcasGA2_TC012468 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 807 4.1e-84 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF02259//PF00728 FAT domain//Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0005515//GO:0043169//GO:0004553 protein binding//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.19170 BP_3 39.00 2.62 1010 111572543 ABH10628.1 960 3.1e-101 laminin receptor [Litopenaeus vannamei] 194763915 XM_001964042.1 198 3.83004e-97 Drosophila ananassae GF21363 (Dana\GF21363), mRNA K02998 RP-SAe, RPSA small subunit ribosomal protein SAe http://www.genome.jp/dbget-bin/www_bget?ko:K02998 A3RLT6 841 8.2e-89 40S ribosomal protein SA OS=Pinctada fucata PE=2 SV=1 PF07259//PF00318 ProSAAS precursor//Ribosomal protein S2 GO:0042254//GO:0010951//GO:0006412 ribosome biogenesis//negative regulation of endopeptidase activity//translation GO:0003735//GO:0004866 structural constituent of ribosome//endopeptidase inhibitor activity GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.19171 BP_3 7.37 0.51 992 332376533 AEE63406.1 279 2.9e-22 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 O75319 234 1.9e-18 RNA/RNP complex-1-interacting phosphatase OS=Homo sapiens GN=DUSP11 PE=1 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.19172 BP_3 302.13 12.87 1423 332376533 AEE63406.1 524 1.6e-50 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 O10274 365 1.8e-33 Putative tyrosine-protein phosphatase 1 OS=Orgyia pseudotsugata multicapsid polyhedrosis virus GN=PTP-1 PE=3 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.19174 BP_3 351.00 52.82 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01874 ATP:dephospho-CoA triphosphoribosyl transferase GO:0016310 phosphorylation GO:0046917//GO:0005524 triphosphoribosyl-dephospho-CoA synthase activity//ATP binding -- -- -- -- Cluster-8309.19175 BP_3 1810.37 14.75 6206 642928875 XP_970065.3 4891 0.0e+00 PREDICTED: nuclear pore membrane glycoprotein 210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEM1 1807 4.9e-200 Nuclear pore membrane glycoprotein 210 OS=Homo sapiens GN=NUP210 PE=1 SV=3 PF01509 TruB family pseudouridylate synthase (N terminal domain) GO:0006396 RNA processing -- -- -- -- KOG1833 Nuclear pore complex, gp210 component Cluster-8309.19176 BP_3 220.10 3.17 3639 728418700 AIY68378.1 1610 4.8e-176 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 665 7.5e-68 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF00067//PF00326//PF07859 Cytochrome P450//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0055114//GO:0006508//GO:0008152 oxidation-reduction process//proteolysis//metabolic process GO:0005506//GO:0008236//GO:0020037//GO:0016787//GO:0016705 iron ion binding//serine-type peptidase activity//heme binding//hydrolase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.1918 BP_3 4.00 0.36 827 795016637 XP_011858564.1 152 1.3e-07 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19180 BP_3 20.18 0.93 1341 646705165 KDR13032.1 774 1.5e-79 Ras-like protein 3 [Zootermopsis nevadensis] 642938605 XM_008201640.1 231 2.31719e-115 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 751 3.0e-78 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF00910//PF00025//PF00071//PF00503//PF01926//PF03193//PF08477 RNA helicase//ADP-ribosylation factor family//Ras family//G-protein alpha subunit//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0007264//GO:0007186 signal transduction//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0003723//GO:0003724//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//RNA binding//RNA helicase activity//guanyl nucleotide binding//signal transducer activity//GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.19182 BP_3 12.41 0.36 1976 478252231 ENN72659.1 601 2.6e-59 hypothetical protein YQE_10757, partial [Dendroctonus ponderosae]>gi|546675747|gb|ERL86879.1| hypothetical protein D910_04282 [Dendroctonus ponderosae] -- -- -- -- -- K11713 PGTB1 geranylgeranyl transferase type-1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K11713 P53610 377 1.0e-34 Geranylgeranyl transferase type-1 subunit beta OS=Rattus norvegicus GN=Pggt1b PE=1 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat -- -- GO:0003824 catalytic activity -- -- KOG0366 Protein geranylgeranyltransferase type II, beta subunit Cluster-8309.19185 BP_3 13.00 0.80 1077 642933354 XP_008197380.1 735 4.1e-75 PREDICTED: uncharacterized protein LOC100142446 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0REX1 206 3.7e-15 Kynurenine formamidase OS=Bacillus thuringiensis (strain Al Hakam) GN=kynB PE=3 SV=1 PF04199 Putative cyclase GO:0046487//GO:0019441//GO:0006568 glyoxylate metabolic process//tryptophan catabolic process to kynurenine//tryptophan metabolic process GO:0004061 arylformamidase activity -- -- -- -- Cluster-8309.19190 BP_3 92.60 0.58 7998 642916033 XP_008190864.1 1601 1.2e-174 PREDICTED: lisH domain and HEAT repeat-containing protein KIAA1468 homolog [Tribolium castaneum]>gi|270003733|gb|EFA00181.1| hypothetical protein TcasGA2_TC003006 [Tribolium castaneum] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q99489 492 1.9e-47 D-aspartate oxidase OS=Homo sapiens GN=DDO PE=2 SV=1 PF06156//PF02985//PF01266 Protein of unknown function (DUF972)//HEAT repeat//FAD dependent oxidoreductase GO:0006260//GO:0055114 DNA replication//oxidation-reduction process GO:0005515//GO:0016491 protein binding//oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.19191 BP_3 167.91 2.46 3577 642916865 XP_008199533.1 1429 4.6e-155 PREDICTED: transcription termination factor 2 [Tribolium castaneum]>gi|270003081|gb|EEZ99528.1| hypothetical protein TcasGA2_TC000110 [Tribolium castaneum] -- -- -- -- -- K15173 TTF2 transcription termination factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15173 P34739 1057 2.6e-113 Transcription termination factor 2 OS=Drosophila melanogaster GN=lds PE=1 SV=2 PF02742//PF03661//PF00176//PF04851 Iron dependent repressor, metal binding and dimerisation domain//Uncharacterised protein family (UPF0121)//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0046914//GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0046983 transition metal ion binding//ATP binding//nucleic acid binding//DNA binding//hydrolase activity//protein dimerization activity GO:0016021 integral component of membrane KOG4439 RNA polymerase II transcription termination factor TTF2/lodestar, DEAD-box superfamily Cluster-8309.19195 BP_3 27.81 2.34 864 642933218 XP_008197312.1 483 5.5e-46 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 259 2.1e-21 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00892//PF00083//PF07690 EamA-like transporter family//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.19201 BP_3 131.26 2.43 2900 270004382 EFA00830.1 718 1.0e-72 hypothetical protein TcasGA2_TC003718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1V2 388 7.9e-36 Cilia- and flagella-associated protein 52 OS=Homo sapiens GN=CFAP52 PE=1 SV=3 PF07967 C3HC zinc finger-like -- -- GO:0008270 zinc ion binding GO:0005634 nucleus KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.19204 BP_3 6.00 1.13 548 821033402 XP_012357823.1 643 9.8e-65 PREDICTED: 40S ribosomal protein S2-like isoform X2 [Nomascus leucogenys] 164689576 AK312173.1 548 0 Homo sapiens cDNA, FLJ92460, Homo sapiens ribosomal protein S2 (RPS2), mRNA K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 P15880 643 4.0e-66 40S ribosomal protein S2 OS=Homo sapiens GN=RPS2 PE=1 SV=2 PF00333 Ribosomal protein S5, N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840 ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-8309.19207 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19214 BP_3 25.03 1.80 961 642915927 XP_008190814.1 470 2.0e-44 PREDICTED: centrosomal protein of 63 kDa-like [Tribolium castaneum]>gi|270003750|gb|EFA00198.1| hypothetical protein TcasGA2_TC003023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14304//PF04977//PF02334//PF06005//PF07716 Transcription termination and cleavage factor C-terminal//Septum formation initiator//Replication terminator protein//Protein of unknown function (DUF904)//Basic region leucine zipper GO:0006274//GO:0031124//GO:0006355//GO:0043093//GO:0000917//GO:0007049 DNA replication termination//mRNA 3'-end processing//regulation of transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.19218 BP_3 250.38 29.20 705 91078608 XP_967155.1 398 3.2e-36 PREDICTED: mitochondrial import inner membrane translocase subunit Tim10 [Tribolium castaneum]>gi|270004056|gb|EFA00504.1| hypothetical protein TcasGA2_TC003366 [Tribolium castaneum] -- -- -- -- -- K17778 TIM10 mitochondrial import inner membrane translocase subunit TIM10 http://www.genome.jp/dbget-bin/www_bget?ko:K17778 Q9W2D6 317 3.3e-28 Mitochondrial import inner membrane translocase subunit Tim10 OS=Drosophila melanogaster GN=Tim10 PE=3 SV=1 -- -- GO:0045039 protein import into mitochondrial inner membrane GO:0046872 metal ion binding GO:0042719//GO:0005743 mitochondrial intermembrane space protein transporter complex//mitochondrial inner membrane KOG3480 Mitochondrial import inner membrane translocase, subunits TIM10/TIM12 Cluster-8309.19219 BP_3 93.82 1.65 3036 91085437 XP_968834.1 682 1.6e-68 PREDICTED: protein zyg-11 homolog [Tribolium castaneum]>gi|270009168|gb|EFA05616.1| hypothetical protein TcasGA2_TC015823 [Tribolium castaneum] 462389525 APGK01019132.1 136 3.43726e-62 Dendroctonus ponderosae Seq01019142, whole genome shotgun sequence K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q9C0D3 412 1.4e-38 Protein zyg-11 homolog B OS=Homo sapiens GN=ZYG11B PE=1 SV=2 PF00073//PF02985 picornavirus capsid protein//HEAT repeat -- -- GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0019028 viral capsid KOG3665 ZYG-1-like serine/threonine protein kinases Cluster-8309.19222 BP_3 3.00 0.97 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854 P-11 zinc finger -- -- GO:0003723//GO:0008270 RNA binding//zinc ion binding -- -- -- -- Cluster-8309.19223 BP_3 10.00 0.54 1189 768801663 AJV86879.1 734 6.0e-75 NADH dehydrogenase subunit 4 (mitochondrion) [Homo sapiens] 893712421 KT277306.1 1189 0 Homo sapiens haplogroup I2 mitochondrion, complete genome K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P03905 734 2.5e-76 NADH-ubiquinone oxidoreductase chain 4 OS=Homo sapiens GN=MT-ND4 PE=1 SV=1 PF00420//PF01059//PF00851 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L//NADH-ubiquinone oxidoreductase chain 4, amino terminus//Helper component proteinase GO:0006120//GO:0006508//GO:0042773//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//proteolysis//ATP synthesis coupled electron transport//oxidation-reduction process GO:0016651//GO:0004197 oxidoreductase activity, acting on NAD(P)H//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.19225 BP_3 36.69 0.42 4471 189236906 XP_001809986.1 2851 0.0e+00 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 1480 2.9e-162 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF13606//PF01529//PF00023//PF00140 Ankyrin repeat//DHHC palmitoyltransferase//Ankyrin repeat//Sigma-70 factor, region 1.2 GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0046872//GO:0003700//GO:0016987//GO:0008270//GO:0005515//GO:0003677 metal ion binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity//zinc ion binding//protein binding//DNA binding GO:0005667 transcription factor complex KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.19226 BP_3 65.41 1.07 3246 270014151 EFA10599.1 721 5.2e-73 hypothetical protein TcasGA2_TC012860 [Tribolium castaneum] 642936605 XM_970801.3 66 3.00872e-23 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 591 2.6e-59 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF00018//PF03248 SH3 domain//Rer1 family -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.19227 BP_3 30.31 0.96 1818 91091328 XP_975894.1 977 6.1e-103 PREDICTED: protein RER1 isoform X2 [Tribolium castaneum] 642936605 XM_970801.3 214 8.92109e-106 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 658 2.4e-67 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.19228 BP_3 465.83 16.31 1668 91091328 XP_975894.1 977 5.6e-103 PREDICTED: protein RER1 isoform X2 [Tribolium castaneum] 642936605 XM_970801.3 214 8.17058e-106 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 658 2.2e-67 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.1923 BP_3 27.57 0.63 2414 270005117 EFA01565.1 2480 4.2e-277 hypothetical protein TcasGA2_TC007126 [Tribolium castaneum] -- -- -- -- -- K16749 BBS7 Bardet-Biedl syndrome 7 protein http://www.genome.jp/dbget-bin/www_bget?ko:K16749 Q8K2G4 1577 8.8e-174 Bardet-Biedl syndrome 7 protein homolog OS=Mus musculus GN=Bbs7 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19230 BP_3 132.55 4.22 1805 270014151 EFA10599.1 884 3.7e-92 hypothetical protein TcasGA2_TC012860 [Tribolium castaneum] 642936605 XM_970801.3 211 4.12032e-104 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 626 1.2e-63 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF03248//PF00018 Rer1 family//SH3 domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.19235 BP_3 50.00 2.30 1339 332374332 AEE62307.1 1195 2.4e-128 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28EM8 363 2.9e-33 LETM1 domain-containing protein 1 OS=Xenopus tropicalis GN=letmd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19237 BP_3 2.49 0.47 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19239 BP_3 492.82 12.17 2243 91078462 XP_967648.1 2154 2.5e-239 PREDICTED: protein SGT1 homolog ecdysoneless [Tribolium castaneum]>gi|270004999|gb|EFA01447.1| hypothetical protein TcasGA2_TC030757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W032 1149 3.5e-124 Protein ecdysoneless OS=Drosophila melanogaster GN=ecd PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2406 MADS box transcription factor Cluster-8309.1924 BP_3 9.00 0.47 1219 817192344 XP_012271607.1 365 3.8e-32 PREDICTED: guanine nucleotide-binding protein subunit gamma-e [Orussus abietinus] 805774666 XM_003701905.2 124 6.35832e-56 PREDICTED: Megachile rotundata guanine nucleotide-binding protein subunit gamma-e (LOC100881351), transcript variant X4, mRNA K04547 GNG13 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 http://www.genome.jp/dbget-bin/www_bget?ko:K04547 Q9NFZ3 335 4.6e-30 Guanine nucleotide-binding protein subunit gamma-e OS=Drosophila melanogaster GN=Ggamma30A PE=1 SV=1 PF00631 GGL domain GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex KOG4119 G protein gamma subunit Cluster-8309.19241 BP_3 9.65 0.54 1155 546673310 ERL84938.1 1144 1.7e-122 hypothetical protein D910_02361 [Dendroctonus ponderosae] -- -- -- -- -- K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 P10040 821 1.9e-86 Protein crumbs OS=Drosophila melanogaster GN=crb PE=1 SV=3 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.19243 BP_3 73.72 2.05 2021 91095049 XP_972102.1 649 7.3e-65 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 339 2.6e-30 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19244 BP_3 655.05 10.97 3169 91085955 XP_971224.1 3102 0.0e+00 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q80V86 755 2.4e-78 Integrator complex subunit 8 OS=Mus musculus GN=Ints8 PE=2 SV=1 PF00515//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19246 BP_3 1.00 12.70 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19250 BP_3 29.18 1.41 1290 642914592 XP_972516.3 486 3.7e-46 PREDICTED: putative peptidyl-tRNA hydrolase PTRHD1 [Tribolium castaneum]>gi|270002266|gb|EEZ98713.1| hypothetical protein TcasGA2_TC001254 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ85 331 1.4e-29 Putative peptidyl-tRNA hydrolase PTRHD1 OS=Bos taurus GN=PTRHD1 PE=2 SV=2 PF01981//PF00083//PF07690 Peptidyl-tRNA hydrolase PTH2//Sugar (and other) transporter//Major Facilitator Superfamily GO:0035335//GO:0006470//GO:0006570//GO:0055085 peptidyl-tyrosine dephosphorylation//protein dephosphorylation//tyrosine metabolic process//transmembrane transport GO:0004725//GO:0022857//GO:0004045 protein tyrosine phosphatase activity//transmembrane transporter activity//aminoacyl-tRNA hydrolase activity GO:0016021 integral component of membrane KOG3305 Uncharacterized conserved protein Cluster-8309.19251 BP_3 33.83 1.12 1745 642932969 XP_008197210.1 2029 6.0e-225 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] 642932968 XM_008198988.1 486 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaw (LOC658450), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1524 8.9e-168 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF00520//PF02214 Ion transport protein//BTB/POZ domain GO:0051260//GO:0006811//GO:0055085 protein homooligomerization//ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.19259 BP_3 2.00 1.15 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19260 BP_3 6.00 3.29 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19262 BP_3 8.00 1.68 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19263 BP_3 16.00 3.42 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19265 BP_3 28.00 0.46 3257 641658932 XP_008180898.1 317 3.7e-26 PREDICTED: KRAB-A domain-containing protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6R2W3 218 4.6e-16 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19269 BP_3 85.88 4.62 1187 189237921 XP_001811995.1 740 1.2e-75 PREDICTED: sperm-associated antigen 7 [Tribolium castaneum]>gi|270006673|gb|EFA03121.1| hypothetical protein TcasGA2_TC013031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SYJ9 365 1.5e-33 Sperm-associated antigen 7 homolog OS=Danio rerio GN=spag7 PE=1 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19270 BP_3 15.12 0.72 1307 189237921 XP_001811995.1 496 2.6e-47 PREDICTED: sperm-associated antigen 7 [Tribolium castaneum]>gi|270006673|gb|EFA03121.1| hypothetical protein TcasGA2_TC013031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75391 192 1.9e-13 Sperm-associated antigen 7 OS=Homo sapiens GN=SPAG7 PE=1 SV=2 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19275 BP_3 7.00 1.73 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19278 BP_3 33.16 0.68 2637 546686075 ERL95475.1 239 3.3e-17 hypothetical protein D910_12737 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1928 BP_3 34.86 0.33 5360 642917080 XP_008191110.1 1932 3.3e-213 PREDICTED: kinesin-like protein KIF18A isoform X2 [Tribolium castaneum] -- -- -- -- -- K10401 KIF18_19 kinesin family member 18/19 http://www.genome.jp/dbget-bin/www_bget?ko:K10401 Q8NI77 1056 5.1e-113 Kinesin-like protein KIF18A OS=Homo sapiens GN=KIF18A PE=1 SV=2 PF04923//PF16752//PF00225//PF02245 Ninjurin//Tubulin-specific chaperone C N-terminal domain//Kinesin motor domain//Methylpurine-DNA glycosylase (MPG) GO:0042246//GO:0007018//GO:0006284//GO:0007155//GO:0007017 tissue regeneration//microtubule-based movement//base-excision repair//cell adhesion//microtubule-based process GO:0003777//GO:0015631//GO:0005524//GO:0003677//GO:0003905//GO:0008017 microtubule motor activity//tubulin binding//ATP binding//DNA binding//alkylbase DNA N-glycosylase activity//microtubule binding GO:0005874//GO:0045298//GO:0016021 microtubule//tubulin complex//integral component of membrane KOG0242 Kinesin-like protein Cluster-8309.19282 BP_3 48.50 0.77 3338 642921567 XP_008192427.1 2080 1.4e-230 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1127 1.9e-121 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF00515//PF13374//PF02891//PF00637//PF13176//PF06464//PF13181//PF00096 Tetratricopeptide repeat//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Region in Clathrin and VPS//Tetratricopeptide repeat//DMAP1-binding Domain//Tetratricopeptide repeat//Zinc finger, C2H2 type GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008134//GO:0005515//GO:0046872//GO:0008270 transcription factor binding//protein binding//metal ion binding//zinc ion binding GO:0005667//GO:0005634//GO:0005622 transcription factor complex//nucleus//intracellular KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.19283 BP_3 37.00 0.39 4855 91086061 XP_973912.1 2040 8.9e-226 PREDICTED: synaptotagmin-16 [Tribolium castaneum] -- -- -- -- -- K19328 SYT14_16 synaptotagmin-14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K19328 Q17RD7 822 6.3e-86 Synaptotagmin-16 OS=Homo sapiens GN=SYT16 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.19285 BP_3 74479.45 2971.08 1500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19286 BP_3 3.67 0.64 566 795019207 XP_011859498.1 216 3.3e-15 PREDICTED: uncharacterized protein LOC105556990 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19290 BP_3 18.00 2.93 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19291 BP_3 501.87 2.32 10725 478253985 ENN74277.1 1873 4.5e-206 hypothetical protein YQE_09249, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7Z026 362 3.0e-32 Protein phosphatase 1 regulatory subunit 37 OS=Bos taurus GN=PPP1R37 PE=2 SV=1 PF00018//PF14604//PF00560//PF07123//PF13516//PF13855 SH3 domain//Variant SH3 domain//Leucine Rich Repeat//Photosystem II reaction centre W protein (PsbW)//Leucine Rich repeat//Leucine rich repeat GO:0015979 photosynthesis GO:0005515 protein binding GO:0009523//GO:0009507 photosystem II//chloroplast -- -- Cluster-8309.19294 BP_3 513.76 13.89 2074 642917373 XP_001806886.2 862 1.5e-89 PREDICTED: N-alpha-acetyltransferase 10 [Tribolium castaneum]>gi|270003017|gb|EEZ99464.1| hypothetical protein TcasGA2_TC000030 [Tribolium castaneum] 675300535 KM377395.1 146 6.45172e-68 Pauropsalta sp. 8 CLO-2014 acetyltransferase (ARD1) gene, partial cds K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 P41227 699 4.9e-72 N-alpha-acetyltransferase 10 OS=Homo sapiens GN=NAA10 PE=1 SV=1 PF00583//PF13508//PF08445//PF13302//PF13673//PF12568 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3235 Subunit of the major N alpha-acetyltransferase Cluster-8309.19296 BP_3 245.43 5.69 2372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19297 BP_3 59.91 1.70 1991 91081315 XP_969699.1 1585 2.1e-173 PREDICTED: protein fuzzy homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HZX7 602 8.3e-61 Protein fuzzy homolog OS=Xenopus tropicalis GN=fuz PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19298 BP_3 420.96 4.88 4450 642930899 XP_008196132.1 1306 1.1e-140 PREDICTED: protein suppressor of sable isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22293 356 6.2e-32 Protein suppressor of sable OS=Drosophila melanogaster GN=su(s) PE=1 SV=2 PF00642//PF06440 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//DNA polymerase III, theta subunit GO:0006260 DNA replication GO:0046872//GO:0003887//GO:0003677 metal ion binding//DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.19299 BP_3 857.06 17.70 2625 546680798 ERL91004.1 1930 2.7e-213 hypothetical protein D910_08346 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q91WR3 275 9.1e-23 Activating signal cointegrator 1 complex subunit 2 OS=Mus musculus GN=Ascc2 PE=2 SV=1 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.193 BP_3 6.00 1.07 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19307 BP_3 10.00 0.61 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19310 BP_3 26.00 1.84 974 290783836 ADD62496.1 169 1.6e-09 gastrolith protein 10 [Cherax quadricarinatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19311 BP_3 315.00 4.97 3347 642918955 XP_008191672.1 909 8.6e-95 PREDICTED: uncharacterized protein LOC103312549 [Tribolium castaneum]>gi|270005610|gb|EFA02058.1| hypothetical protein TcasGA2_TC007688 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19312 BP_3 4.00 0.49 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19313 BP_3 45.17 0.59 4005 242012387 XP_002426914.1 735 1.5e-74 conserved hypothetical protein [Pediculus humanus corporis]>gi|212511143|gb|EEB14176.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q9N2M8 640 6.6e-65 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 PF00616//PF03376 GTPase-activator protein for Ras-like GTPase//Adenovirus E3B protein GO:0043087 regulation of GTPase activity -- -- GO:0016020 membrane KOG3816 Cell differentiation regulator of the Headcase family Cluster-8309.19314 BP_3 9.00 0.93 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19316 BP_3 11.00 0.73 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19321 BP_3 24.41 0.46 2847 642935081 XP_008197876.1 288 7.4e-23 PREDICTED: calmodulin-binding transcription activator 2-like isoform X2 [Tribolium castaneum] 642935084 XM_008199656.1 77 2.02242e-29 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.19322 BP_3 77.76 1.53 2744 642930915 XP_008196139.1 330 9.7e-28 PREDICTED: limulus clotting factor C-like isoform X2 [Tribolium castaneum]>gi|270012763|gb|EFA09211.1| serine protease P69 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 139 5.6e-07 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 -- -- GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19323 BP_3 146.00 3.86 2116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19324 BP_3 272.62 3.08 4553 642916563 XP_008191711.1 329 2.1e-27 PREDICTED: uncharacterized protein LOC660226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NEL2 162 2.0e-09 Ankyrin repeat domain-containing protein SOWAHB OS=Homo sapiens GN=SOWAHB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.19327 BP_3 196.45 2.99 3457 642935773 XP_966401.2 3513 0.0e+00 PREDICTED: trafficking protein particle complex subunit 10 [Tribolium castaneum]>gi|270013291|gb|EFA09739.1| hypothetical protein TcasGA2_TC011874 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VFB7 1521 3.9e-167 Trafficking protein particle complex subunit 10 OS=Drosophila melanogaster GN=SIDL PE=1 SV=1 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG1931 Putative transmembrane protein Cluster-8309.19330 BP_3 159.67 2.46 3415 189235374 XP_001809693.1 2197 3.9e-244 PREDICTED: potassium voltage-gated channel protein Shaker isoform X1 [Tribolium castaneum] 642916511 XM_001809641.2 1072 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X1, mRNA K05318 KCNAN potassium voltage-gated channel Shaker-related subfamily A, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05318 P08510 1926 4.2e-214 Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 PF00520//PF00060 Ion transport protein//Ligand-gated ion channel GO:0055085//GO:0007165//GO:0006811//GO:0007268 transmembrane transport//signal transduction//ion transport//synaptic transmission GO:0005216//GO:0004970 ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.19332 BP_3 23.00 1.28 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19333 BP_3 4.55 0.71 600 270006157 EFA02605.1 175 2.0e-10 hypothetical protein TcasGA2_TC008324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19334 BP_3 279.07 4.06 3601 91082339 XP_966549.1 5329 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC2 [Tribolium castaneum]>gi|270007487|gb|EFA03935.1| hypothetical protein TcasGA2_TC014075 [Tribolium castaneum] 719740584 XM_010211158.1 114 6.9324e-50 PREDICTED: Tinamus guttatus DNA-directed RNA polymerase III subunit RPC2 (LOC104564515), partial mRNA K03021 RPC2, POLR3B DNA-directed RNA polymerase III subunit RPC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03021 P25167 4251 0.0e+00 DNA-directed RNA polymerase III subunit RPC2 OS=Drosophila melanogaster GN=RpIII128 PE=2 SV=2 PF04567//PF04561//PF04565//PF04566//PF04560//PF00562//PF04563 RNA polymerase Rpb2, domain 5//RNA polymerase Rpb2, domain 2//RNA polymerase Rpb2, domain 3//RNA polymerase Rpb2, domain 4//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 6//RNA polymerase beta subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0032549 DNA binding//DNA-directed RNA polymerase activity//ribonucleoside binding GO:0005730 nucleolus KOG0215 RNA polymerase III, second largest subunit Cluster-8309.19335 BP_3 8929.00 490.58 1169 478255798 ENN76006.1 503 3.6e-48 hypothetical protein YQE_07385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T635 303 2.3e-26 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.19337 BP_3 4.00 0.32 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19338 BP_3 1281.14 39.48 1856 642917903 XP_008191376.1 1043 1.4e-110 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 270 2.4e-22 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19339 BP_3 3.00 0.72 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1934 BP_3 28.00 1.87 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19340 BP_3 6.72 1.82 469 646718490 KDR20930.1 317 5.3e-27 hypothetical protein L798_03868 [Zootermopsis nevadensis] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 Q8CDJ3 187 2.6e-13 Beclin 1-associated autophagy-related key regulator OS=Mus musculus GN=Atg14 PE=1 SV=1 PF10186 Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy -- -- -- -- -- -- Cluster-8309.19342 BP_3 1000.24 12.63 4108 642910693 XP_008200063.1 3431 0.0e+00 PREDICTED: neurogenic locus protein delta [Tribolium castaneum]>gi|270014506|gb|EFA10954.1| hypothetical protein TcasGA2_TC004114 [Tribolium castaneum] 642910692 XM_008201841.1 779 0 PREDICTED: Tribolium castaneum neurogenic locus protein delta (LOC658619), mRNA K06051 DLL delta http://www.genome.jp/dbget-bin/www_bget?ko:K06051 Q9IAT6 1432 9.8e-157 Delta-like protein C OS=Danio rerio GN=dlc PE=2 SV=1 PF01414//PF07657//PF07645//PF00008 Delta serrate ligand//N terminus of Notch ligand//Calcium-binding EGF domain//EGF-like domain GO:0007219//GO:0007275//GO:0007154 Notch signaling pathway//multicellular organismal development//cell communication GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.19344 BP_3 37.98 0.63 3213 642929814 XP_008195987.1 1086 2.5e-115 PREDICTED: E3 ubiquitin-protein ligase Topors-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10631 TOPORS E3 ubiquitin-protein ligase Topors http://www.genome.jp/dbget-bin/www_bget?ko:K10631 Q9V8P9 485 5.0e-47 E3 ubiquitin-protein ligase Topors OS=Drosophila melanogaster GN=Topors PE=1 SV=1 PF12861//PF05793//PF16685//PF00257//PF13639//PF00097//PF14634//PF12678//PF01480 Anaphase-promoting complex subunit 11 RING-H2 finger//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//zinc RING finger of MSL2//Dehydrin//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-H2 zinc finger//PWI domain GO:0006367//GO:0009415//GO:0032968//GO:0006397//GO:0006950//GO:0016567 transcription initiation from RNA polymerase II promoter//response to water//positive regulation of transcription elongation from RNA polymerase II promoter//mRNA processing//response to stress//protein ubiquitination GO:0008270//GO:0046872//GO:0003677//GO:0005515//GO:0061630//GO:0004842 zinc ion binding//metal ion binding//DNA binding//protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity GO:0005634//GO:0005680 nucleus//anaphase-promoting complex KOG4430 Topoisomerase I-binding arginine-serine-rich protein Cluster-8309.19346 BP_3 50.76 0.54 4862 270013369 EFA09817.1 454 7.2e-42 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- K17963 PPRC1, PRC peroxisome proliferator-activated receptor gamma coactivator-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17963 Q6NZN1 232 1.6e-17 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Mus musculus GN=Pprc1 PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- -- -- Cluster-8309.19347 BP_3 37.87 0.38 5122 270013369 EFA09817.1 818 4.7e-84 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- K17963 PPRC1, PRC peroxisome proliferator-activated receptor gamma coactivator-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17963 Q5VV67 169 3.5e-10 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Homo sapiens GN=PPRC1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19348 BP_3 32.28 0.37 4445 761263427 AJP36493.1 677 9.1e-68 nicotinic acetylcholine receptor alpha 7 [Leptinotarsa decemlineata] 227439246 EU937796.1 171 1.76619e-81 Tribolium castaneum nicotinic acetylcholine receptor a7 subunit (nAChRA7) mRNA, nAChRA7-v2 allele, complete cds, alternatively spliced K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P48180 147 1.1e-07 Acetylcholine receptor subunit alpha-type acr-16 OS=Caenorhabditis elegans GN=acr-16 PE=2 SV=1 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3646 Acetylcholine receptor Cluster-8309.19349 BP_3 354.60 6.80 2806 646716704 KDR19844.1 661 4.1e-66 hypothetical protein L798_05910 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W440 592 1.7e-59 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.19352 BP_3 7.00 0.54 917 742138592 XP_010878205.1 158 2.8e-08 PREDICTED: ATP synthase F(0) complex subunit C3, mitochondrial [Esox lucius] 697065682 XM_009649733.1 542 0 Verticillium dahliae VdLs.17 ATP synthase protein mRNA -- -- -- -- P00842 359 5.8e-33 ATP synthase subunit 9, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=oli PE=1 SV=1 PF00137 ATP synthase subunit C GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.19353 BP_3 11.61 0.36 1838 91088681 XP_974930.1 974 1.4e-102 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JFV8 462 1.3e-44 Synaptic vesicle membrane protein VAT-1 homolog OS=Danio rerio GN=vat1 PE=2 SV=1 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0005488 binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.19355 BP_3 25.66 0.54 2564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19356 BP_3 7.36 0.58 909 332373980 AEE62131.1 721 1.5e-73 unknown [Dendroctonus ponderosae]>gi|478250944|gb|ENN71428.1| hypothetical protein YQE_11847, partial [Dendroctonus ponderosae]>gi|546682688|gb|ERL92600.1| hypothetical protein D910_09913 [Dendroctonus ponderosae] -- -- -- -- -- K10640 RNF25, AO7 E3 ubiquitin-protein ligase RNF25 http://www.genome.jp/dbget-bin/www_bget?ko:K10640 Q9QZR0 272 7.0e-23 E3 ubiquitin-protein ligase RNF25 OS=Mus musculus GN=Rnf25 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19357 BP_3 136.37 7.24 1199 189242493 XP_972306.2 1155 9.1e-124 PREDICTED: E3 ubiquitin-protein ligase RNF25 [Tribolium castaneum] -- -- -- -- -- K10640 RNF25, AO7 E3 ubiquitin-protein ligase RNF25 http://www.genome.jp/dbget-bin/www_bget?ko:K10640 Q9QZR0 455 5.6e-44 E3 ubiquitin-protein ligase RNF25 OS=Mus musculus GN=Rnf25 PE=1 SV=2 PF13639//PF00097//PF17123//PF05773//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RWD domain//zinc-RING finger domain -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG4445 Uncharacterized conserved protein, contains RWD domain Cluster-8309.19360 BP_3 150.22 1.56 4948 91089075 XP_971233.1 492 2.9e-46 PREDICTED: cell cycle checkpoint protein RAD17 [Tribolium castaneum]>gi|270011521|gb|EFA07969.1| hypothetical protein TcasGA2_TC005551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 165 9.7e-10 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.19362 BP_3 89.22 8.95 772 91089075 XP_971233.1 450 3.3e-42 PREDICTED: cell cycle checkpoint protein RAD17 [Tribolium castaneum]>gi|270011521|gb|EFA07969.1| hypothetical protein TcasGA2_TC005551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XT62 223 2.9e-17 Cell cycle checkpoint protein RAD17 OS=Chlorocebus aethiops GN=RAD17 PE=1 SV=1 PF00437//PF00004//PF00448//PF07728//PF05496//PF01580//PF00910//PF00005//PF03193//PF01637//PF06414//PF02367//PF04851 Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//SRP54-type protein, GTPase domain//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//FtsK/SpoIIIE family//RNA helicase//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Type III restriction enzyme, res subunit GO:0002949//GO:0006310//GO:0006810//GO:0006281//GO:0006614 tRNA threonylcarbamoyladenosine modification//DNA recombination//transport//DNA repair//SRP-dependent cotranslational protein targeting to membrane GO:0009378//GO:0003724//GO:0005525//GO:0003723//GO:0003677//GO:0000166//GO:0016301//GO:0016887//GO:0003924//GO:0005524//GO:0016787 four-way junction helicase activity//RNA helicase activity//GTP binding//RNA binding//DNA binding//nucleotide binding//kinase activity//ATPase activity//GTPase activity//ATP binding//hydrolase activity GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component Cluster-8309.19366 BP_3 5.93 0.36 1083 270008369 EFA04817.1 339 3.4e-29 hypothetical protein TcasGA2_TC014867 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NPA5 233 2.8e-18 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF06397//PF04988//PF13465//PF00096 Desulfoferrodoxin, N-terminal domain//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0005506//GO:0046872//GO:0003677 iron ion binding//metal ion binding//DNA binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.19368 BP_3 53.67 0.40 6786 861628028 KMQ89256.1 1308 9.4e-141 piggybac transposable element-derived protein 4-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- Q96DM1 264 4.4e-21 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF01609//PF07776 Transposase DDE domain//Zinc-finger associated domain (zf-AD) GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677//GO:0008270 transposase activity//DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.19369 BP_3 51.74 0.43 6129 861628028 KMQ89256.1 1308 8.5e-141 piggybac transposable element-derived protein 4-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- Q96DM1 264 4.0e-21 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF07776//PF01609 Zinc-finger associated domain (zf-AD)//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677//GO:0008270 transposase activity//DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.19370 BP_3 27.36 0.43 3339 478260883 ENN80520.1 273 4.8e-21 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.19371 BP_3 79.96 2.16 2080 478260883 ENN80520.1 273 3.0e-21 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.19372 BP_3 23.41 0.60 2185 478260883 ENN80520.1 273 3.1e-21 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.19380 BP_3 8.27 0.39 1316 546675493 ERL86678.1 555 3.8e-54 hypothetical protein D910_04084 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19381 BP_3 945.70 48.12 1239 546675493 ERL86678.1 548 2.3e-53 hypothetical protein D910_04084 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19388 BP_3 19.53 0.53 2065 270006871 EFA03319.1 310 1.5e-25 hypothetical protein TcasGA2_TC013262 [Tribolium castaneum] 462314888 APGK01045625.1 35 3.25323e-06 Dendroctonus ponderosae Seq01045635, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19389 BP_3 742.74 14.57 2749 642923986 XP_008193958.1 2809 0.0e+00 PREDICTED: dystrobrevin beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70585 1164 7.8e-126 Dystrobrevin beta OS=Mus musculus GN=Dtnb PE=1 SV=3 PF07649//PF00569//PF06657 C1-like domain//Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57 GO:0055114 oxidation-reduction process GO:0008017//GO:0008270//GO:0047134 microtubule binding//zinc ion binding//protein-disulfide reductase activity GO:0045298 tubulin complex KOG4301 Beta-dystrobrevin Cluster-8309.19390 BP_3 51.94 1.04 2707 270006871 EFA03319.1 2727 1.1e-305 hypothetical protein TcasGA2_TC013262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70585 1178 1.8e-127 Dystrobrevin beta OS=Mus musculus GN=Dtnb PE=1 SV=3 PF07649//PF00569//PF06657 C1-like domain//Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57 GO:0055114 oxidation-reduction process GO:0047134//GO:0008270//GO:0008017 protein-disulfide reductase activity//zinc ion binding//microtubule binding GO:0045298 tubulin complex KOG4301 Beta-dystrobrevin Cluster-8309.19391 BP_3 110.03 1.42 4018 642923986 XP_008193958.1 1668 1.0e-182 PREDICTED: dystrobrevin beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60941 855 7.7e-90 Dystrobrevin beta OS=Homo sapiens GN=DTNB PE=1 SV=1 PF07649//PF00569//PF06657 C1-like domain//Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57 GO:0055114 oxidation-reduction process GO:0008017//GO:0008270//GO:0047134 microtubule binding//zinc ion binding//protein-disulfide reductase activity GO:0045298 tubulin complex -- -- Cluster-8309.19392 BP_3 96.13 1.43 3525 642923986 XP_008193958.1 1893 7.1e-209 PREDICTED: dystrobrevin beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60941 957 1.0e-101 Dystrobrevin beta OS=Homo sapiens GN=DTNB PE=1 SV=1 PF00569//PF06657//PF07649 Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57//C1-like domain GO:0055114 oxidation-reduction process GO:0047134//GO:0008017//GO:0008270 protein-disulfide reductase activity//microtubule binding//zinc ion binding GO:0045298 tubulin complex -- -- Cluster-8309.19394 BP_3 0.41 0.37 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19395 BP_3 6.00 0.52 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19397 BP_3 28.84 0.45 3387 642910866 XP_001813884.2 483 2.2e-45 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] 642910867 XM_008195218.1 67 8.73282e-24 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase, H3 lysine-79 specific (LOC660658), transcript variant X2, mRNA K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 -- -- -- -- PF05191 Adenylate kinase, active site lid GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0004017 adenylate kinase activity -- -- -- -- Cluster-8309.19399 BP_3 17.14 0.44 2188 91087247 XP_975518.1 450 9.4e-42 PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929756|ref|XP_008195961.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929758|ref|XP_008195962.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929760|ref|XP_008195963.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 -- -- -- -- PF00083//PF06800//PF03137//PF07690 Sugar (and other) transporter//Sugar transport protein//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0008643//GO:0034219//GO:0006810//GO:0055085 carbohydrate transport//carbohydrate transmembrane transport//transport//transmembrane transport GO:0005215//GO:0015144//GO:0022857 transporter activity//carbohydrate transmembrane transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.194 BP_3 12.76 0.46 1631 270003105 EEZ99552.1 218 5.6e-15 hypothetical protein TcasGA2_TC000134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF07496//PF00130 PHD-finger//CW-type Zinc Finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.19403 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19407 BP_3 678.18 9.67 3671 270004569 EFA01017.1 1392 9.2e-151 hypothetical protein TcasGA2_TC003931 [Tribolium castaneum] -- -- -- -- -- K18625 SHROOM protein Shroom http://www.genome.jp/dbget-bin/www_bget?ko:K18625 Q09JY9 372 7.2e-34 Protein Shroom2 OS=Xenopus tropicalis GN=shroom2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19408 BP_3 14.43 1.16 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19411 BP_3 27.41 0.80 1935 642931897 XP_008196773.1 436 3.5e-40 PREDICTED: SUZ domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GR00 200 3.3e-14 SUZ domain-containing protein 1 OS=Xenopus laevis GN=szrd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19412 BP_3 435.35 13.90 1801 642931897 XP_008196773.1 465 1.4e-43 PREDICTED: SUZ domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GR00 200 3.1e-14 SUZ domain-containing protein 1 OS=Xenopus laevis GN=szrd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19415 BP_3 11.00 0.70 1045 642915056 XP_008190391.1 259 6.3e-20 PREDICTED: uncharacterized protein LOC103312182 [Tribolium castaneum]>gi|270001357|gb|EEZ97804.1| hypothetical protein TcasGA2_TC000168 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19416 BP_3 204.19 2.43 4341 189235365 XP_967323.2 1414 3.1e-153 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270004239|gb|EFA00687.1| hypothetical protein TcasGA2_TC003564 [Tribolium castaneum] 815793565 XM_012361984.1 64 5.21968e-22 PREDICTED: Linepithema humile uncharacterized LOC105669183 (LOC105669183), mRNA -- -- -- -- Q9VCA2 377 2.2e-34 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.19421 BP_3 178.00 9.49 1196 546676950 ERL87874.1 228 2.8e-16 hypothetical protein D910_05262 [Dendroctonus ponderosae] -- -- -- -- -- K02919 RP-L36, MRPL36, rpmJ large subunit ribosomal protein L36 http://www.genome.jp/dbget-bin/www_bget?ko:K02919 -- -- -- -- PF00444//PF06374 Ribosomal protein L36//NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006120//GO:0006412//GO:0006814//GO:0006744//GO:0015992//GO:0042254 mitochondrial electron transport, NADH to ubiquinone//translation//sodium ion transport//ubiquinone biosynthetic process//proton transport//ribosome biogenesis GO:0003735//GO:0008137 structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity GO:0005743//GO:0005840//GO:0005622 mitochondrial inner membrane//ribosome//intracellular -- -- Cluster-8309.19422 BP_3 85.03 2.10 2245 847164383 XP_012826122.1 666 8.6e-67 PREDICTED: uncharacterized protein LOC105948364 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677//GO:0016788 transposase activity//DNA binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.19423 BP_3 949.18 14.98 3345 91094203 XP_971608.1 2074 7.0e-230 PREDICTED: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [Tribolium castaneum]>gi|270010912|gb|EFA07360.1| hypothetical protein TcasGA2_TC015960 [Tribolium castaneum] 826492697 XM_012684964.1 53 5.22677e-16 PREDICTED: Monomorium pharaonis probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (LOC105838989), mRNA K03847 ALG12 alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03847 Q9VH78 1420 2.0e-155 Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster GN=CG8412 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) Cluster-8309.19425 BP_3 5.00 1.31 476 190589906 ACE79213.1 686 8.8e-70 heat shock protein 70 [Scylla paramamosain]>gi|418206087|gb|AFX62572.1| heat shock protein 70 [Scylla paramamosain]>gi|418206089|gb|AFX62573.1| heat shock protein 70 [Scylla paramamosain]>gi|418206091|gb|AFX62574.1| heat shock protein 70 [Scylla paramamosain]>gi|418206093|gb|AFX62575.1| heat shock protein 70 [Scylla paramamosain]>gi|418206095|gb|AFX62576.1| heat shock protein 70 [Scylla paramamosain]>gi|418206097|gb|AFX62577.1| heat shock protein 70 [Scylla paramamosain]>gi|418206099|gb|AFX62578.1| heat shock protein 70 [Scylla paramamosain] 190589905 EU754021.1 476 0 Scylla paramamosain heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P08108 608 4.0e-62 Heat shock cognate 70 kDa protein OS=Oncorhynchus mykiss GN=hsc71 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.19426 BP_3 178.00 4.01 2429 546673262 ERL84900.1 1192 9.5e-128 hypothetical protein D910_02323 [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 824 1.8e-86 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF09238//PF00287 Interleukin-4 receptor alpha chain, N-terminal//Sodium / potassium ATPase beta chain GO:0006813//GO:0007165//GO:0006814//GO:0002532 potassium ion transport//signal transduction//sodium ion transport//production of molecular mediator involved in inflammatory response GO:0004896 cytokine receptor activity GO:0016021//GO:0005890 integral component of membrane//sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.19427 BP_3 158.00 10.69 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19428 BP_3 12.67 1.43 720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19433 BP_3 9.66 0.45 1321 642910457 XP_008190746.1 1296 4.5e-140 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum]>gi|642910459|ref|XP_008190747.1| PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum] 347969268 XM_003436347.1 39 1.2316e-08 Anopheles gambiae str. PEST AGAP003108-PB (AgaP_AGAP003108) mRNA, complete cds K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P22607 903 6.9e-96 Fibroblast growth factor receptor 3 OS=Homo sapiens GN=FGFR3 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.19435 BP_3 50.84 0.88 3087 270015126 EFA11574.1 2461 8.6e-275 heartless [Tribolium castaneum] 462340826 APGK01036266.1 85 7.8393e-34 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1459 5.4e-160 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF13895//PF00069//PF07714 Immunoglobulin domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- -- -- Cluster-8309.19437 BP_3 31.14 1.47 1313 270015126 EFA11574.1 1296 4.5e-140 heartless [Tribolium castaneum] 347969268 XM_003436347.1 39 1.22394e-08 Anopheles gambiae str. PEST AGAP003108-PB (AgaP_AGAP003108) mRNA, complete cds K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P22607 903 6.9e-96 Fibroblast growth factor receptor 3 OS=Homo sapiens GN=FGFR3 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.19439 BP_3 2295.66 27.72 4284 91083631 XP_970382.1 4149 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.7017e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 P11024 3168 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Bos taurus GN=NNT PE=1 SV=3 PF00107//PF07074//PF00005//PF02233//PF02826//PF03188//PF01752//PF00205 Zinc-binding dehydrogenase//Translocon-associated protein, gamma subunit (TRAP-gamma)//ABC transporter//NAD(P) transhydrogenase beta subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Collagenase//Thiamine pyrophosphate enzyme, central domain GO:0006613//GO:0046497//GO:0055114//GO:0015992//GO:0006769//GO:0006508 cotranslational protein targeting to membrane//nicotinate nucleotide metabolic process//oxidation-reduction process//proton transport//nicotinamide metabolic process//proteolysis GO:0005524//GO:0008750//GO:0016887//GO:0008270//GO:0004252//GO:0050661//GO:0051287//GO:0000287//GO:0030976 ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//ATPase activity//zinc ion binding//serine-type endopeptidase activity//NADP binding//NAD binding//magnesium ion binding//thiamine pyrophosphate binding GO:0016021//GO:0030176//GO:0005784//GO:0005576 integral component of membrane//integral component of endoplasmic reticulum membrane//Sec61 translocon complex//extracellular region -- -- Cluster-8309.19443 BP_3 90.68 1.26 3770 91095023 XP_970355.1 729 7.2e-74 PREDICTED: inhibin beta chain [Tribolium castaneum]>gi|270015436|gb|EFA11884.1| dawdle [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 O61643 219 4.1e-16 Inhibin beta chain OS=Drosophila melanogaster GN=Actbeta PE=2 SV=2 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity GO:0005576 extracellular region -- -- Cluster-8309.19444 BP_3 2.00 1.33 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19449 BP_3 3.00 0.31 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09254 Restriction endonuclease FokI, C terminal GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.1945 BP_3 1.00 0.36 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19453 BP_3 55.79 0.31 9092 642926389 XP_008194905.1 4852 0.0e+00 PREDICTED: citron Rho-interacting kinase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14578 2070 2.3e-230 Citron Rho-interacting kinase OS=Homo sapiens GN=CIT PE=1 SV=2 PF00130//PF13851//PF00827//PF07714//PF01326//PF00433//PF00069 Phorbol esters/diacylglycerol binding domain (C1 domain)//Growth-arrest specific micro-tubule binding//Ribosomal L15//Protein tyrosine kinase//Pyruvate phosphate dikinase, PEP/pyruvate binding domain//Protein kinase C terminal domain//Protein kinase domain GO:0006468//GO:0009069//GO:0016310//GO:0006412//GO:0048870//GO:0035556//GO:0042254 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//translation//cell motility//intracellular signal transduction//ribosome biogenesis GO:0005524//GO:0004674//GO:0004672//GO:0003735//GO:0016301 ATP binding//protein serine/threonine kinase activity//protein kinase activity//structural constituent of ribosome//kinase activity GO:0031514//GO:0005840 motile cilium//ribosome KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.19454 BP_3 667.88 50.12 934 268370065 NP_001161226.1 701 3.1e-71 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [Tribolium castaneum]>gi|270014564|gb|EFA11012.1| LOW QUALITY PROTEIN: hypothetical protein TcasGA2_TC004599 [Tribolium castaneum] 686803186 LM223515.1 42 1.85318e-10 Strongylus vulgaris genome assembly S_vulgaris_Kentucky ,scaffold SVUK_scaffold0011471 K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q91V37 494 1.3e-48 V-type proton ATPase 21 kDa proteolipid subunit OS=Mus musculus GN=Atp6v0b PE=1 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.19456 BP_3 112.06 1.97 3031 672273128 KFG45225.1 147 1.8e-06 IgA-specific metalloendopeptidase [Toxoplasma gondii GAB2-2007-GAL-DOM2] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03502 Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279 cell outer membrane -- -- Cluster-8309.19461 BP_3 53.63 0.56 4920 478251276 ENN71747.1 2015 7.1e-223 hypothetical protein YQE_11567, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5U239 686 3.7e-70 Transmembrane protein 145 OS=Xenopus laevis GN=tmem145 PE=2 SV=1 PF10192//PF06814 Rhodopsin-like GPCR transmembrane domain//Lung seven transmembrane receptor GO:0019236//GO:0007186 response to pheromone//G-protein coupled receptor signaling pathway -- -- GO:0016021 integral component of membrane KOG2901 Uncharacterized conserved protein Cluster-8309.19463 BP_3 35.91 2.76 919 642936711 XP_008200418.1 1111 8.8e-119 PREDICTED: eukaryotic initiation factor 4E isoform X1 [Tribolium castaneum] 642936710 XM_008202196.1 172 9.86319e-83 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4E (eIF-4E), transcript variant X1, mRNA K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 Q8BMB3 606 1.3e-61 Eukaryotic translation initiation factor 4E type 2 OS=Mus musculus GN=Eif4e2 PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.19466 BP_3 130.95 3.41 2145 642927675 XP_008195360.1 1255 4.2e-135 PREDICTED: NAD kinase 2, mitochondrial, partial [Tribolium castaneum] -- -- -- -- -- K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 Q1HCL7 635 1.3e-64 NAD kinase 2, mitochondrial OS=Rattus norvegicus GN=Nadk2 PE=2 SV=1 PF01513//PF00781//PF03575 ATP-NAD kinase//Diacylglycerol kinase catalytic domain//Peptidase family S51 GO:0006508//GO:0006741//GO:0006769//GO:0008152//GO:0046497 proteolysis//NADP biosynthetic process//nicotinamide metabolic process//metabolic process//nicotinate nucleotide metabolic process GO:0016301//GO:0008236//GO:0003951 kinase activity//serine-type peptidase activity//NAD+ kinase activity -- -- KOG4180 Predicted kinase Cluster-8309.19469 BP_3 30.00 0.63 2584 478259248 ENN79150.1 608 5.3e-60 hypothetical protein YQE_04336, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04728//PF14817//PF06009//PF07989//PF10392//PF04513 Lipoprotein leucine-zipper//HAUS augmin-like complex subunit 5//Laminin Domain II//Centrosomin N-terminal motif 1//Golgi transport complex subunit 5//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0051225//GO:0006891//GO:0007155 spindle assembly//intra-Golgi vesicle-mediated transport//cell adhesion GO:0005198 structural molecule activity GO:0019031//GO:0005815//GO:0019028//GO:0019867//GO:0070652//GO:0017119 viral envelope//microtubule organizing center//viral capsid//outer membrane//HAUS complex//Golgi transport complex -- -- Cluster-8309.19473 BP_3 38.63 0.54 3716 642936336 XP_008198400.1 2005 7.8e-222 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1252 6.6e-136 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF00570//PF00196//PF09382//PF00270//PF04851//PF06480 HRDC domain//Bacterial regulatory proteins, luxR family//RQC domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//FtsH Extracellular GO:0006281//GO:0006355//GO:0006260 DNA repair//regulation of transcription, DNA-templated//DNA replication GO:0005524//GO:0004222//GO:0003677//GO:0016787//GO:0043140//GO:0008270//GO:0003676 ATP binding//metalloendopeptidase activity//DNA binding//hydrolase activity//ATP-dependent 3'-5' DNA helicase activity//zinc ion binding//nucleic acid binding GO:0016021//GO:0005657//GO:0005622 integral component of membrane//replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.19475 BP_3 4.00 0.51 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19476 BP_3 42.49 4.00 804 170321839 BAG14264.1 455 9.1e-43 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q26422 228 7.8e-18 Limulus clotting factor C OS=Carcinoscorpius rotundicauda PE=2 SV=1 PF00089//PF16045//PF02189 Trypsin//LisH//Immunoreceptor tyrosine-based activation motif GO:0007166//GO:0006508//GO:0007165 cell surface receptor signaling pathway//proteolysis//signal transduction GO:0005515//GO:0004252//GO:0004888 protein binding//serine-type endopeptidase activity//transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.19479 BP_3 29.84 1.12 1577 642912272 XP_008200632.1 476 6.5e-45 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90WD8 166 2.4e-10 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19480 BP_3 715.38 13.36 2873 91086355 XP_974424.1 1157 1.3e-123 PREDICTED: transcription factor TFIIIB component B'' homolog [Tribolium castaneum]>gi|270010281|gb|EFA06729.1| hypothetical protein TcasGA2_TC009660 [Tribolium castaneum] -- -- -- -- -- K15198 BDP1, TFC5 transcription factor TFIIIB component B'' http://www.genome.jp/dbget-bin/www_bget?ko:K15198 Q571C7 315 2.3e-27 Transcription factor TFIIIB component B'' homolog OS=Mus musculus GN=Bdp1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2009 Transcription initiation factor TFIIIB, Bdp1 subunit Cluster-8309.19482 BP_3 2828.00 95.17 1724 270005985 EFA02433.1 283 1.7e-22 hypothetical protein TcasGA2_TC008120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19484 BP_3 6.00 0.68 720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19486 BP_3 5.00 0.35 990 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19488 BP_3 22.93 0.63 2056 478254642 ENN74884.1 1051 1.8e-111 hypothetical protein YQE_08549, partial [Dendroctonus ponderosae]>gi|546679235|gb|ERL89729.1| hypothetical protein D910_07090 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A0N0X6 253 2.5e-20 Leucine-rich repeat neuronal protein 1 OS=Bos taurus GN=LRRN1 PE=3 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.1949 BP_3 33.00 0.51 3432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19492 BP_3 1.00 0.55 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19494 BP_3 23.00 0.36 3381 270007992 EFA04440.1 701 1.1e-70 hypothetical protein TcasGA2_TC014742 [Tribolium castaneum] -- -- -- -- -- K18754 LIN28 protein lin-28 http://www.genome.jp/dbget-bin/www_bget?ko:K18754 Q9VRN5 534 1.1e-52 Protein lin-28 homolog OS=Drosophila melanogaster GN=lin-28 PE=2 SV=2 PF08024//PF00098//PF00313 Ant antimicrobial peptide//Zinc knuckle//'Cold-shock' DNA-binding domain GO:0006355//GO:0019836 regulation of transcription, DNA-templated//hemolysis by symbiont of host erythrocytes GO:0008270//GO:0003676//GO:0003677 zinc ion binding//nucleic acid binding//DNA binding GO:0005576 extracellular region KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.19496 BP_3 220.89 4.21 2822 642936911 XP_008194442.1 3085 0.0e+00 PREDICTED: PHD finger protein 14 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4H9 1117 2.3e-120 PHD finger protein 14 OS=Mus musculus GN=Phf14 PE=1 SV=1 PF06156//PF00628//PF02059//PF01017//PF00130 Protein of unknown function (DUF972)//PHD-finger//Interleukin-3//STAT protein, all-alpha domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006955//GO:0006260//GO:0006355//GO:0035556//GO:0007165//GO:0040007//GO:0008283 immune response//DNA replication//regulation of transcription, DNA-templated//intracellular signal transduction//signal transduction//growth//cell proliferation GO:0004871//GO:0003700//GO:0008083//GO:0005135//GO:0005515 signal transducer activity//transcription factor activity, sequence-specific DNA binding//growth factor activity//interleukin-3 receptor binding//protein binding GO:0005894//GO:0005576//GO:0005667 interleukin-3 receptor complex//extracellular region//transcription factor complex KOG0957 PHD finger protein Cluster-8309.19498 BP_3 7.00 1.25 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.195 BP_3 32.00 0.58 2934 642932504 XP_008197141.1 675 1.0e-67 PREDICTED: kielin/chordin-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12297//PF00093 Ellis van Creveld protein 2 like protein//von Willebrand factor type C domain GO:0007224 smoothened signaling pathway GO:0005515 protein binding -- -- -- -- Cluster-8309.1950 BP_3 5.00 0.46 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19501 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19507 BP_3 42.56 0.53 4176 270009006 EFA05454.1 893 7.7e-93 hypothetical protein TcasGA2_TC015635 [Tribolium castaneum] -- -- -- -- -- K14995 SLC38A9 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14995 Q19425 524 1.9e-51 Sodium-coupled neutral amino acid transporter 9 homolog OS=Caenorhabditis elegans GN=F13H10.3 PE=3 SV=2 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane -- -- Cluster-8309.19511 BP_3 376.47 5.85 3391 478254666 ENN74907.1 2515 5.2e-281 hypothetical protein YQE_08485, partial [Dendroctonus ponderosae] -- -- -- -- -- K18085 MTMR10_11_12 myotubularin-related protein 10/11/12 http://www.genome.jp/dbget-bin/www_bget?ko:K18085 Q6NU08 902 2.3e-95 Myotubularin-related protein 10-B OS=Xenopus laevis GN=mtmr10-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.19512 BP_3 31.87 0.51 3332 642924705 XP_008194405.1 3519 0.0e+00 PREDICTED: inactive dipeptidyl peptidase 10 isoform X1 [Tribolium castaneum]>gi|270007980|gb|EFA04428.1| hypothetical protein TcasGA2_TC014728 [Tribolium castaneum] 642924706 XM_008196184.1 77 2.37136e-29 PREDICTED: Tribolium castaneum inactive dipeptidyl peptidase 10 (LOC663947), transcript variant X2, mRNA -- -- -- -- Q5IS50 990 1.4e-105 Dipeptidyl aminopeptidase-like protein 6 OS=Pan troglodytes GN=DPP6 PE=2 SV=1 PF00930//PF00326 Dipeptidyl peptidase IV (DPP IV) N-terminal region//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity GO:0016020 membrane KOG2100 Dipeptidyl aminopeptidase Cluster-8309.19515 BP_3 1.00 0.99 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19516 BP_3 413.00 19.06 1336 478257348 ENN77508.1 731 1.5e-74 hypothetical protein YQE_06034, partial [Dendroctonus ponderosae] -- -- -- -- -- K14306 NUP62, NSP1 nuclear pore complex protein Nup62 http://www.genome.jp/dbget-bin/www_bget?ko:K14306 P37198 451 1.8e-43 Nuclear pore glycoprotein p62 OS=Homo sapiens GN=NUP62 PE=1 SV=3 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- KOG2196 Nuclear porin Cluster-8309.19517 BP_3 31.87 0.79 2227 642916064 XP_970366.3 1755 4.5e-193 PREDICTED: twinkle protein, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17680 PEO1 twinkle protein http://www.genome.jp/dbget-bin/www_bget?ko:K17680 Q96RR1 1092 1.4e-117 Twinkle protein, mitochondrial OS=Homo sapiens GN=PEO1 PE=1 SV=1 PF03796//PF06009//PF00437//PF01637//PF00005//PF03193//PF06689//PF01807 DnaB-like helicase C terminal domain//Laminin Domain II//Type II/IV secretion system protein//Archaeal ATPase//ABC transporter//Protein of unknown function, DUF258//ClpX C4-type zinc finger//CHC2 zinc finger GO:0007155//GO:0006351//GO:0006269//GO:0006260//GO:0006810 cell adhesion//transcription, DNA-templated//DNA replication, synthesis of RNA primer//DNA replication//transport GO:0005525//GO:0046983//GO:0003678//GO:0003677//GO:0008270//GO:0016887//GO:0003924//GO:0005524//GO:0003896 GTP binding//protein dimerization activity//DNA helicase activity//DNA binding//zinc ion binding//ATPase activity//GTPase activity//ATP binding//DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2373 Predicted mitochondrial DNA helicase twinkle Cluster-8309.19518 BP_3 190.00 8.98 1312 642916924 XP_971551.3 1515 1.8e-165 PREDICTED: diphthamide biosynthesis protein 1 [Tribolium castaneum]>gi|270003030|gb|EEZ99477.1| hypothetical protein TcasGA2_TC000051 [Tribolium castaneum] 815770825 XM_012380143.1 72 5.53124e-27 PREDICTED: Linepithema humile diphthamide biosynthesis protein 1 (LOC105679855), mRNA K07561 dph2, DPH1 2-(3-amino-3-carboxypropyl)histidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K07561 Q6GPQ5 1224 4.1e-133 Diphthamide biosynthesis protein 1 OS=Xenopus laevis GN=dph1 PE=2 SV=2 -- -- GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine -- -- GO:0005737 cytoplasm KOG2648 Diphthamide biosynthesis protein Cluster-8309.19519 BP_3 161.00 9.86 1079 478256835 ENN77010.1 959 4.4e-101 hypothetical protein YQE_06504, partial [Dendroctonus ponderosae] -- -- -- -- -- K06997 yggS, PROSC PLP dependent protein http://www.genome.jp/dbget-bin/www_bget?ko:K06997 O94903 715 3.6e-74 Proline synthase co-transcribed bacterial homolog protein OS=Homo sapiens GN=PROSC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3157 Proline synthetase co-transcribed protein Cluster-8309.19521 BP_3 32.32 0.48 3564 91094511 XP_971832.1 460 1.1e-42 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.59272e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 Q8VHV7 277 7.2e-23 Heterogeneous nuclear ribonucleoprotein H OS=Rattus norvegicus GN=Hnrnph1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.19523 BP_3 271.00 9.56 1658 91077876 XP_972781.1 1089 5.7e-116 PREDICTED: mediator of RNA polymerase II transcription subunit 4 [Tribolium castaneum] -- -- -- -- -- K15146 MED4 mediator of RNA polymerase II transcription subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15146 Q7QH62 785 4.2e-82 Mediator of RNA polymerase II transcription subunit 4 OS=Anopheles gambiae GN=MED4 PE=3 SV=3 PF04888//PF03255//PF10018//PF04111 Secretion system effector C (SseC) like family//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Vitamin-D-receptor interacting Mediator subunit 4//Autophagy protein Apg6 GO:0006357//GO:0006090//GO:0009405//GO:0006633//GO:0006914 regulation of transcription from RNA polymerase II promoter//pyruvate metabolic process//pathogenesis//fatty acid biosynthetic process//autophagy GO:0003989//GO:0001104 acetyl-CoA carboxylase activity//RNA polymerase II transcription cofactor activity GO:0009317//GO:0016592 acetyl-CoA carboxylase complex//mediator complex KOG4552 Vitamin-D-receptor interacting protein complex component Cluster-8309.19529 BP_3 113.00 0.94 6071 270005633 EFA02081.1 293 4.2e-23 hypothetical protein TcasGA2_TC007716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1953 BP_3 1.00 3.39 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19530 BP_3 116.00 3.60 1846 478260093 ENN79878.1 1495 5.3e-163 hypothetical protein YQE_03697, partial [Dendroctonus ponderosae]>gi|546676554|gb|ERL87543.1| hypothetical protein D910_04934, partial [Dendroctonus ponderosae] -- -- -- -- -- K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 O61303 1302 5.2e-142 Opsin, ultraviolet-sensitive OS=Apis mellifera GN=UVOP PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.19531 BP_3 575.14 6.27 4715 546686185 ERL95565.1 341 8.8e-29 hypothetical protein D910_12826 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19532 BP_3 22.00 0.34 3423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03739//PF06455//PF00895//PF02285 Predicted permease YjgP/YjgQ family//NADH dehydrogenase subunit 5 C-terminus//ATP synthase protein 8//Cytochrome oxidase c subunit VIII GO:0006814//GO:0006744//GO:0015986//GO:0055114//GO:0015992//GO:0006123//GO:0042773//GO:0006120 sodium ion transport//ubiquinone biosynthetic process//ATP synthesis coupled proton transport//oxidation-reduction process//proton transport//mitochondrial electron transport, cytochrome c to oxygen//ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone GO:0015078//GO:0004129//GO:0008137 hydrogen ion transmembrane transporter activity//cytochrome-c oxidase activity//NADH dehydrogenase (ubiquinone) activity GO:0000276//GO:0016021//GO:0045277 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane//respiratory chain complex IV -- -- Cluster-8309.19535 BP_3 25.00 2.52 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19536 BP_3 239.25 43.29 558 478258777 ENN78800.1 325 7.5e-28 hypothetical protein YQE_04737, partial [Dendroctonus ponderosae]>gi|546678780|gb|ERL89332.1| hypothetical protein D910_06704 [Dendroctonus ponderosae] 42764849 AY439820.1 76 1.35679e-29 Armigeres subalbatus ASAP ID: 40029 barrier-to-autointegration factor mRNA sequence -- -- -- -- Q9R1T1 272 4.3e-23 Barrier-to-autointegration factor OS=Rattus norvegicus GN=Banf1 PE=1 SV=1 PF02961 Barrier to autointegration factor -- -- GO:0003677 DNA binding -- -- KOG4233 DNA-bridging protein BAF Cluster-8309.19537 BP_3 111.74 5.23 1321 642924337 XP_008194253.1 1524 1.6e-166 PREDICTED: LOW QUALITY PROTEIN: protein RCC2 homolog [Tribolium castaneum] 462382197 APGK01021748.1 134 1.90661e-61 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 931 3.9e-99 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19538 BP_3 3.40 0.41 692 478261443 ENN80813.1 275 5.8e-22 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19539 BP_3 70.11 0.48 7287 646710743 KDR16161.1 745 1.9e-75 Formin-binding protein 1-like protein [Zootermopsis nevadensis] 462295608 APGK01052682.1 49 1.91569e-13 Dendroctonus ponderosae Seq01052692, whole genome shotgun sequence -- -- -- -- Q5T0N5 363 1.6e-32 Formin-binding protein 1-like OS=Homo sapiens GN=FNBP1L PE=1 SV=3 PF14604//PF00018//PF02185 Variant SH3 domain//SH3 domain//Hr1 repeat GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.19542 BP_3 31.70 5.43 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19544 BP_3 266.78 8.41 1821 270015237 EFA11685.1 1452 5.1e-158 hypothetical protein TcasGA2_TC008549 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS86 887 6.8e-94 LanC-like protein 2 OS=Homo sapiens GN=LANCL2 PE=1 SV=1 PF04223 Citrate lyase, alpha subunit (CitF) GO:0006084//GO:0006099 acetyl-CoA metabolic process//tricarboxylic acid cycle GO:0008814 citrate CoA-transferase activity GO:0009346//GO:0005737 citrate lyase complex//cytoplasm KOG2787 Lanthionine synthetase C-like protein 1 Cluster-8309.19547 BP_3 155.69 2.02 4011 642938488 XP_008197979.1 2563 1.7e-286 PREDICTED: rho guanine nucleotide exchange factor 9 isoform X3 [Tribolium castaneum] 805759873 XM_012297744.1 247 8.99225e-124 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 1.6e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00018//PF14604//PF00621 SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.1955 BP_3 9.00 0.46 1232 156353812 XP_001623105.1 797 3.1e-82 predicted protein [Nematostella vectensis]>gi|156209766|gb|EDO31005.1| predicted protein [Nematostella vectensis] 697066660 XM_009650222.1 1053 0 Verticillium dahliae VdLs.17 60S ribosomal protein L4-B partial mRNA K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P35679 867 9.6e-92 60S ribosomal protein L4-A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl402 PE=1 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-8309.19552 BP_3 12.00 0.46 1546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19553 BP_3 86.37 0.78 5603 641660547 XP_008181531.1 1180 5.4e-126 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944//PF04827 BESS motif//Plant transposon protein -- -- GO:0003677//GO:0016788 DNA binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.19555 BP_3 231.36 3.71 3298 270004708 EFA01156.1 460 9.8e-43 hypothetical protein TcasGA2_TC010381 [Tribolium castaneum] -- -- -- -- -- K18749 LSM14, RAP55, SCD6 protein LSM14 http://www.genome.jp/dbget-bin/www_bget?ko:K18749 Q566L7 195 2.2e-13 Protein LSM14 homolog B OS=Xenopus tropicalis GN=lsm14b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1073 Uncharacterized mRNA-associated protein RAP55 Cluster-8309.19560 BP_3 3.00 1.03 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19562 BP_3 13.10 1.48 719 546672885 ERL84608.1 202 1.8e-13 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 156 1.6e-09 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF00811 Ependymin GO:0007160 cell-matrix adhesion GO:0005509 calcium ion binding GO:0005576 extracellular region -- -- Cluster-8309.19565 BP_3 2.00 0.41 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19567 BP_3 134.37 0.86 7824 642920114 XP_008192211.1 1223 7.8e-131 PREDICTED: E3 ubiquitin-protein ligase SH3RF1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.6e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF00097//PF14604//PF00018//PF14634//PF17123//PF09360//PF13639 Zinc finger, C3HC4 type (RING finger)//Variant SH3 domain//SH3 domain//zinc-RING finger domain//RING-like zinc finger//Iron-binding zinc finger CDGSH type//Ring finger domain -- -- GO:0008270//GO:0051537//GO:0005515//GO:0046872 zinc ion binding//2 iron, 2 sulfur cluster binding//protein binding//metal ion binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.19569 BP_3 16.00 19.96 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19572 BP_3 14.55 0.31 2539 646714240 KDR18285.1 433 1.0e-39 DnaJ-like protein subfamily B member 12 [Zootermopsis nevadensis] -- -- -- -- -- K09518 DNAJB12 DnaJ homolog subfamily B member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09518 Q9NXW2 267 7.4e-22 DnaJ homolog subfamily B member 12 OS=Homo sapiens GN=DNAJB12 PE=1 SV=4 PF05929 Phage capsid scaffolding protein (GPO) serine peptidase GO:0019069 viral capsid assembly -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.19576 BP_3 4.00 2.22 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02150//PF00096//PF13465 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.19580 BP_3 904.12 52.61 1120 642922922 XP_971943.2 772 2.2e-79 PREDICTED: coiled-coil domain-containing protein 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T312 581 1.3e-58 Coiled-coil domain-containing protein 25 OS=Danio rerio GN=ccdc25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3272 Predicted coiled-coil protein Cluster-8309.19583 BP_3 9.07 0.79 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19586 BP_3 616.59 4.33 7149 642917646 XP_008193467.1 1224 5.4e-131 PREDICTED: activating transcription factor 7-interacting protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6VMQ6 269 1.2e-21 Activating transcription factor 7-interacting protein 1 OS=Homo sapiens GN=ATF7IP PE=1 SV=3 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19590 BP_3 15.36 0.37 2313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19591 BP_3 21.00 1.28 1081 91076690 XP_971724.1 310 7.9e-26 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 58 2.74961e-19 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 A2APY7 244 1.5e-19 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Mus musculus GN=Ndufaf5 PE=2 SV=1 PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- KOG2940 Predicted methyltransferase Cluster-8309.19592 BP_3 34.00 1.46 1412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02229 Transcriptional Coactivator p15 (PC4) GO:0006355 regulation of transcription, DNA-templated GO:0003713//GO:0003677 transcription coactivator activity//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.19596 BP_3 73.38 3.14 1419 642932585 XP_008196912.1 445 2.3e-41 PREDICTED: S-adenosylmethionine decarboxylase proenzyme isoform X1 [Tribolium castaneum] -- -- -- -- -- K01611 speD, AMD1 S-adenosylmethionine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01611 P91931 262 1.6e-21 S-adenosylmethionine decarboxylase proenzyme OS=Drosophila melanogaster GN=SamDC PE=2 SV=1 PF01536 Adenosylmethionine decarboxylase GO:0006525//GO:0006597//GO:0008295//GO:0006560 arginine metabolic process//spermine biosynthetic process//spermidine biosynthetic process//proline metabolic process GO:0004014 adenosylmethionine decarboxylase activity -- -- KOG0788 S-adenosylmethionine decarboxylase Cluster-8309.19600 BP_3 393.28 3.25 6132 91093076 XP_968784.1 713 8.4e-72 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 626 4.2e-63 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.19607 BP_3 82.87 1.76 2563 478260221 ENN79984.1 222 3.0e-15 hypothetical protein YQE_03578, partial [Dendroctonus ponderosae]>gi|546675215|gb|ERL86451.1| hypothetical protein D910_03858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19608 BP_3 3.64 0.46 672 642932529 XP_008197152.1 196 8.1e-13 PREDICTED: type-1 angiotensin II receptor-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19612 BP_3 158.58 14.64 814 642924540 XP_008194336.1 435 1.9e-40 PREDICTED: larval cuticle protein LCP-30 [Tribolium castaneum]>gi|270006766|gb|EFA03214.1| hypothetical protein TcasGA2_TC013134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08738 267 2.4e-22 Larval cuticle protein LCP-30 OS=Bombyx mori GN=LCP30 PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.19615 BP_3 5.42 0.34 1049 642924004 XP_008193965.1 762 3.0e-78 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 343 4.7e-31 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF00400//PF03275 WD domain, G-beta repeat//UDP-galactopyranose mutase -- -- GO:0005515//GO:0008767 protein binding//UDP-galactopyranose mutase activity -- -- KOG1188 WD40 repeat protein Cluster-8309.19616 BP_3 29.23 0.79 2068 642924004 XP_008193965.1 942 7.9e-99 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 350 1.4e-31 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF00400//PF03275 WD domain, G-beta repeat//UDP-galactopyranose mutase -- -- GO:0008767//GO:0005515 UDP-galactopyranose mutase activity//protein binding -- -- KOG1188 WD40 repeat protein Cluster-8309.19617 BP_3 28.09 1.79 1050 642924004 XP_008193965.1 778 4.2e-80 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 337 2.3e-30 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1188 WD40 repeat protein Cluster-8309.1962 BP_3 8.00 0.57 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19620 BP_3 367.41 10.07 2051 546678419 ERL89042.1 730 3.0e-74 hypothetical protein D910_06420 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR0 414 5.4e-39 Kelch domain-containing protein 10 OS=Mus musculus GN=Klhdc10 PE=1 SV=1 PF09187//PF00892//PF01344//PF07646 Domain of unknown function(DUF1950)//EamA-like transporter family//Kelch motif//Kelch motif GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0016021//GO:0005634 membrane//integral component of membrane//nucleus -- -- Cluster-8309.19621 BP_3 30.65 0.81 2107 478259245 ENN79147.1 612 1.5e-60 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28DE7 378 8.3e-35 Kelch domain-containing protein 10 OS=Xenopus tropicalis GN=klhdc10 PE=2 SV=2 PF07646//PF01344//PF00892//PF09187 Kelch motif//Kelch motif//EamA-like transporter family//Domain of unknown function(DUF1950) GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0016021//GO:0005634 membrane//integral component of membrane//nucleus -- -- Cluster-8309.19622 BP_3 66.91 1.90 1990 478259245 ENN79147.1 405 1.4e-36 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0IIC2 236 2.3e-18 Kelch domain-containing protein 10 OS=Bos taurus GN=KLHDC10 PE=2 SV=1 PF07646//PF01344//PF09187//PF00892 Kelch motif//Kelch motif//Domain of unknown function(DUF1950)//EamA-like transporter family GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0005634//GO:0016021 membrane//nucleus//integral component of membrane -- -- Cluster-8309.19629 BP_3 24.58 1.01 1465 826409641 XP_012534005.1 166 5.4e-09 PREDICTED: uncharacterized protein LOC105835358, partial [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1963 BP_3 18.10 2.56 633 642915881 XP_008196364.1 141 1.8e-06 PREDICTED: cuticle protein 65-like [Tribolium castaneum]>gi|270004064|gb|EFA00512.1| hypothetical protein TcasGA2_TC003376 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19630 BP_3 19.11 0.76 1510 768418838 XP_011550121.1 301 1.2e-24 PREDICTED: uncharacterized protein LOC105382004 [Plutella xylostella]>gi|768424236|ref|XP_011553062.1| PREDICTED: uncharacterized protein LOC105384507 [Plutella xylostella]>gi|768439288|ref|XP_011561267.1| PREDICTED: uncharacterized protein LOC105391485 [Plutella xylostella]>gi|768449353|ref|XP_011566757.1| PREDICTED: uncharacterized protein LOC105396454 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00603 Influenza RNA-dependent RNA polymerase subunit PA GO:0006144//GO:0006351 purine nucleobase metabolic process//transcription, DNA-templated GO:0003968//GO:0003723 RNA-directed RNA polymerase activity//RNA binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.19634 BP_3 40.35 0.31 6494 642929061 XP_008195675.1 1517 5.2e-165 PREDICTED: metastasis suppressor protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9S0 859 4.3e-90 MTSS1-like protein OS=Mus musculus GN=Mtss1l PE=1 SV=1 PF08397//PF02205//PF14980 IRSp53/MIM homology domain//WH2 motif//TIP39 peptide GO:0007009//GO:0007218 plasma membrane organization//neuropeptide signaling pathway GO:0003779 actin binding GO:0005576 extracellular region -- -- Cluster-8309.19637 BP_3 97.00 4.00 1460 91082005 XP_969623.1 1498 1.9e-163 PREDICTED: general transcription factor IIE subunit 1 [Tribolium castaneum]>gi|270007311|gb|EFA03759.1| hypothetical protein TcasGA2_TC013870 [Tribolium castaneum] 665785740 XM_008550591.1 225 5.47287e-112 PREDICTED: Microplitis demolitor general transcription factor IIE subunit 1 (LOC103572130), transcript variant X2, mRNA K03136 TFIIE1, GTF2E1, TFA1, tfe transcription initiation factor TFIIE subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03136 A6QLI8 784 4.8e-82 General transcription factor IIE subunit 1 OS=Bos taurus GN=GTF2E1 PE=2 SV=1 PF13912//PF13465//PF00318 C2H2-type zinc finger//Zinc-finger double domain//Ribosomal protein S2 GO:0006367//GO:0042254//GO:0006412 transcription initiation from RNA polymerase II promoter//ribosome biogenesis//translation GO:0043565//GO:0003735//GO:0046872 sequence-specific DNA binding//structural constituent of ribosome//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular KOG2593 Transcription initiation factor IIE, alpha subunit Cluster-8309.19638 BP_3 478.45 4.76 5132 642937669 XP_008198894.1 1681 4.0e-184 PREDICTED: uncharacterized protein LOC103314480 [Tribolium castaneum]>gi|270001142|gb|EEZ97589.1| hypothetical protein TcasGA2_TC011452 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02119 Flagellar P-ring protein GO:0071973 bacterial-type flagellum-dependent cell motility GO:0005198//GO:0016772 structural molecule activity//transferase activity, transferring phosphorus-containing groups GO:0009428//GO:0030288 bacterial-type flagellum basal body, distal rod, P ring//outer membrane-bounded periplasmic space -- -- Cluster-8309.19640 BP_3 33.00 3.96 693 227955307 ACP43443.1 637 6.1e-64 arginine kinase [Scylla olivacea] 388267610 JQ031765.1 690 0 Scylla paramamosain arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 Q9GYX1 636 3.3e-65 Arginine kinase OS=Pachygrapsus marmoratus PE=2 SV=1 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.19642 BP_3 55.00 2.03 1600 227955307 ACP43443.1 1761 6.6e-194 arginine kinase [Scylla olivacea] 388267610 JQ031765.1 862 0 Scylla paramamosain arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 Q9NH49 1750 5.1e-194 Arginine kinase OS=Callinectes sapidus PE=2 SV=1 PF02807//PF00217 ATP:guanido phosphotransferase, N-terminal domain//ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016772//GO:0016301 transferase activity, transferring phosphorus-containing groups//kinase activity -- -- KOG3581 Creatine kinases Cluster-8309.19644 BP_3 16.33 0.84 1229 642931541 XP_008196629.1 946 1.6e-99 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 Q09499 510 2.4e-50 Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=1 SV=2 -- -- GO:0006397//GO:0006468//GO:0009069//GO:0016310//GO:0051252 mRNA processing//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//regulation of RNA metabolic process GO:0005524//GO:0016891//GO:0004674 ATP binding//endoribonuclease activity, producing 5'-phosphomonoesters//protein serine/threonine kinase activity -- -- KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.19645 BP_3 91.49 2.43 2104 642931541 XP_008196629.1 1804 8.9e-199 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 O75460 1229 1.7e-133 Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens GN=ERN1 PE=1 SV=2 PF06479//PF00804//PF06293//PF00069//PF07714 Ribonuclease 2-5A//Syntaxin//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0044260//GO:0006397//GO:0044238//GO:0051252 protein phosphorylation//cellular macromolecule metabolic process//mRNA processing//primary metabolic process//regulation of RNA metabolic process GO:0004540//GO:0005524//GO:0004672//GO:0016773 ribonuclease activity//ATP binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.19647 BP_3 3.00 0.63 520 546673982 ERL85486.1 184 1.6e-11 hypothetical protein D910_02905 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19650 BP_3 313.93 11.78 1576 270011477 EFA07925.1 1108 3.4e-118 hypothetical protein TcasGA2_TC005503 [Tribolium castaneum] 817212223 XM_012426867.1 34 8.88214e-06 PREDICTED: Orussus abietinus pancreatic triacylglycerol lipase-like (LOC105700724), mRNA -- -- -- -- P54318 350 1.1e-31 Pancreatic lipase-related protein 2 OS=Rattus norvegicus GN=Pnliprp2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19651 BP_3 16.07 0.68 1428 270011477 EFA07925.1 857 3.9e-89 hypothetical protein TcasGA2_TC005503 [Tribolium castaneum] 817212223 XM_012426867.1 34 8.02909e-06 PREDICTED: Orussus abietinus pancreatic triacylglycerol lipase-like (LOC105700724), mRNA K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q9WVG5 310 4.3e-27 Endothelial lipase OS=Mus musculus GN=Lipg PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19653 BP_3 4.00 0.33 875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.19654 BP_3 287.39 3.25 4552 91087139 XP_975272.1 1440 3.1e-156 PREDICTED: zinc finger protein PLAG1 [Tribolium castaneum]>gi|270009590|gb|EFA06038.1| hypothetical protein TcasGA2_TC008868 [Tribolium castaneum] 642929548 XM_970179.2 86 3.22621e-34 PREDICTED: Tribolium castaneum zinc finger protein PLAG1 (LOC664166), mRNA K19484 PLAG1 zinc finger protein PLAG1 http://www.genome.jp/dbget-bin/www_bget?ko:K19484 A6NDX5 384 3.6e-35 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF16622//PF07975//PF00130//PF13465//PF00096 zinc-finger C2H2-type//TFIIH C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556//GO:0006281 intracellular signal transduction//DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.19655 BP_3 446.00 11.78 2117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19657 BP_3 64.93 3.36 1222 546676446 ERL87451.1 215 9.3e-15 hypothetical protein D910_04843 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.19658 BP_3 9.30 0.38 1474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19665 BP_3 99.00 2.00 2672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1967 BP_3 12.00 0.31 2166 768422837 XP_011552295.1 2265 3.2e-252 PREDICTED: glutamate dehydrogenase, mitochondrial [Plutella xylostella] 748203607 KM189809.1 2148 0 Scylla paramamosain clone 2014J-670 glutamate dehydrogenase (GDH) mRNA, complete cds K00261 GLUD1_2, gdhA glutamate dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00261 P54385 2197 1.0e-245 Glutamate dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=Gdh PE=1 SV=2 PF00208//PF02812 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases Cluster-8309.19675 BP_3 37.90 0.34 5732 642925144 XP_008194444.1 1180 5.5e-126 PREDICTED: WSCD family member AGAP003962 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16WU7 876 4.0e-92 WSCD family member AAEL009094 OS=Aedes aegypti GN=AAEL009094 PE=3 SV=1 PF00569//PF01356//PF00685//PF02485 Zinc finger, ZZ type//Alpha amylase inhibitor//Sulfotransferase domain//Core-2/I-Branching enzyme -- -- GO:0008375//GO:0008270//GO:0008146//GO:0015066 acetylglucosaminyltransferase activity//zinc ion binding//sulfotransferase activity//alpha-amylase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.19676 BP_3 21.13 1.68 897 91080889 XP_973062.1 907 3.9e-95 PREDICTED: ER degradation-enhancing alpha-mannosidase-like protein 2 [Tribolium castaneum]>gi|270005396|gb|EFA01844.1| hypothetical protein TcasGA2_TC007447 [Tribolium castaneum] 462316750 APGK01044966.1 63 3.76575e-22 Dendroctonus ponderosae Seq01044976, whole genome shotgun sequence K10085 EDEM2 ER degradation enhancer, mannosidase alpha-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10085 Q9BV94 675 1.3e-69 ER degradation-enhancing alpha-mannosidase-like protein 2 OS=Homo sapiens GN=EDEM2 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0016020 membrane KOG2429 Glycosyl hydrolase, family 47 Cluster-8309.19678 BP_3 2.00 0.71 426 -- -- -- -- -- 820857101 XM_003696473.2 62 6.16973e-22 PREDICTED: Apis florea 26S proteasome complex subunit DSS1 (LOC100863585), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1968 BP_3 5.00 0.31 1074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19681 BP_3 21.20 0.33 3433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01139//PF03854 tRNA-splicing ligase RtcB//P-11 zinc finger GO:0006396 RNA processing GO:0008452//GO:0003723//GO:0008270 RNA ligase activity//RNA binding//zinc ion binding -- -- -- -- Cluster-8309.19683 BP_3 66.40 5.87 837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19688 BP_3 8.35 0.41 1268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19692 BP_3 334.00 6.70 2695 189237962 XP_001811853.1 1252 1.2e-134 PREDICTED: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 [Tribolium castaneum]>gi|270006659|gb|EFA03107.1| hypothetical protein TcasGA2_TC013017 [Tribolium castaneum] 242011225 XM_002426311.1 145 3.02508e-67 Pediculus humanus corporis nuclear lim interactor-interacting factor, putative, mRNA K15731 CTDSP carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K15731 Q9GZU7 821 4.5e-86 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 OS=Homo sapiens GN=CTDSP1 PE=1 SV=1 -- -- GO:0016311 dephosphorylation GO:0016791 phosphatase activity -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.19694 BP_3 258.53 12.69 1274 642927694 XP_008196569.1 306 2.7e-25 PREDICTED: uncharacterized protein LOC103313889 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064//PF00008 Thrombomodulin like fifth domain, EGF-like//EGF-like domain GO:0007165 signal transduction GO:0004888//GO:0005515 transmembrane signaling receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.19695 BP_3 174.99 12.87 947 499140776 AGL76355.1 265 1.1e-20 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 241 2.9e-19 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05531//PF16331//PF03998 Nucleopolyhedrovirus P10 protein//TolA binding protein trimerisation//Utp11 protein GO:0070206//GO:0006364 protein trimerization//rRNA processing -- -- GO:0032040//GO:0019028 small-subunit processome//viral capsid -- -- Cluster-8309.19696 BP_3 326.69 7.34 2436 642917000 XP_008199589.1 815 4.9e-84 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 243 4.3e-19 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19697 BP_3 207.49 9.37 1359 270016115 EFA12563.1 255 2.4e-19 hypothetical protein TcasGA2_TC004192 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1970 BP_3 32.00 1.74 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09107 Elongation factor SelB, winged helix GO:0006448//GO:0001514 regulation of translational elongation//selenocysteine incorporation GO:0003723//GO:0005525//GO:0003746 RNA binding//GTP binding//translation elongation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm -- -- Cluster-8309.19705 BP_3 44.60 1.87 1442 642927952 XP_008195459.1 1721 2.6e-189 PREDICTED: protein pellino isoform X1 [Tribolium castaneum]>gi|270011061|gb|EFA07509.1| hypothetical protein TcasGA2_TC009672 [Tribolium castaneum] 642927955 XM_962215.3 264 1.12905e-133 PREDICTED: Tribolium castaneum protein pellino (LOC662980), transcript variant X3, mRNA K11964 PELI pellino http://www.genome.jp/dbget-bin/www_bget?ko:K11964 O77237 1372 3.1e-150 Protein pellino OS=Drosophila melanogaster GN=Pli PE=1 SV=1 PF05203//PF04710//PF01899//PF14634 Hom_end-associated Hint//Pellino//Na+/H+ ion antiporter subunit//zinc-RING finger domain GO:0006812//GO:0030908//GO:0008063 cation transport//protein splicing//Toll signaling pathway GO:0008270//GO:0008324//GO:0005515 zinc ion binding//cation transmembrane transporter activity//protein binding GO:0016021 integral component of membrane KOG3842 Adaptor protein Pellino Cluster-8309.19707 BP_3 8.00 0.85 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00228 Bowman-Birk serine protease inhibitor family -- -- GO:0004867 serine-type endopeptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.19708 BP_3 30.00 2.42 890 665794141 XP_008544754.1 674 4.0e-68 PREDICTED: pseudouridine-5'-monophosphatase isoform X1 [Microplitis demolitor] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 617 6.8e-63 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.19709 BP_3 149.34 18.21 687 91089817 XP_969063.1 323 1.6e-27 PREDICTED: protein anon-73B1 [Tribolium castaneum]>gi|270013595|gb|EFA10043.1| hypothetical protein TcasGA2_TC012215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06783//PF01741//PF05038 Uncharacterised protein family (UPF0239)//Large-conductance mechanosensitive channel, MscL//Cytochrome Cytochrome b558 alpha-subunit GO:0006811//GO:0006810 ion transport//transport GO:0005216//GO:0020037 ion channel activity//heme binding GO:0016021 integral component of membrane -- -- Cluster-8309.19712 BP_3 18.62 0.32 3097 478260882 ENN80519.1 1083 5.3e-115 hypothetical protein YQE_03058, partial [Dendroctonus ponderosae]>gi|546671739|gb|ERL83923.1| hypothetical protein D910_01216 [Dendroctonus ponderosae]>gi|546675041|gb|ERL86299.1| hypothetical protein D910_03707 [Dendroctonus ponderosae] 572257831 XM_006607250.1 36 1.36348e-06 PREDICTED: Apis dorsata tyrosine-protein kinase PR2-like (LOC102681833), mRNA -- -- -- -- Q9I7F7 244 4.2e-19 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF03943//PF01529//PF06423 TAP C-terminal domain//DHHC palmitoyltransferase//GWT1 GO:0006506//GO:0051028 GPI anchor biosynthetic process//mRNA transport GO:0008270//GO:0016746 zinc ion binding//transferase activity, transferring acyl groups GO:0005789//GO:0016021//GO:0005634 endoplasmic reticulum membrane//integral component of membrane//nucleus -- -- Cluster-8309.19714 BP_3 35.95 0.93 2151 642928668 XP_008199729.1 1704 3.6e-187 PREDICTED: protein daughterless isoform X6 [Tribolium castaneum] 642928667 XM_008201507.1 306 7.62542e-157 PREDICTED: Tribolium castaneum protein daughterless (LOC662057), transcript variant X6, mRNA K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P11420 591 1.7e-59 Protein daughterless OS=Drosophila melanogaster GN=da PE=1 SV=1 PF00010//PF02854 Helix-loop-helix DNA-binding domain//MIF4G domain -- -- GO:0005515//GO:0046983//GO:0003723 protein binding//protein dimerization activity//RNA binding -- -- KOG3910 Helix loop helix transcription factor Cluster-8309.1972 BP_3 11.00 0.64 1124 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19721 BP_3 1.00 2.34 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19722 BP_3 138.77 2.27 3240 642931756 XP_968911.2 887 3.0e-92 PREDICTED: endonuclease III-like protein 1 [Tribolium castaneum] -- -- -- -- -- K10773 NTH endonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K10773 Q2KID2 739 1.8e-76 Endonuclease III-like protein 1 OS=Bos taurus GN=NTHL1 PE=2 SV=1 PF16045//PF00730//PF09398//PF00633 LisH//HhH-GPD superfamily base excision DNA repair protein//FOP N terminal dimerisation domain//Helix-hairpin-helix motif GO:0006284//GO:0034453 base-excision repair//microtubule anchoring GO:0005515//GO:0003677 protein binding//DNA binding GO:0005815 microtubule organizing center KOG1921 Endonuclease III Cluster-8309.19727 BP_3 1.58 0.35 511 817190080 XP_012270394.1 140 1.9e-06 PREDICTED: longitudinals lacking protein, isoforms A/B/D/L isoform X46 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02176//PF00096 TRAF-type zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.19728 BP_3 30.00 0.82 2064 751239627 XP_011173810.1 200 8.6e-13 PREDICTED: uncharacterized protein LOC105205974, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19730 BP_3 80.77 0.61 6655 642917330 XP_008199256.1 3229 0.0e+00 PREDICTED: kazrin isoform X4 [Tribolium castaneum] 642917329 XM_008201034.1 521 0 PREDICTED: Tribolium castaneum kazrin (LOC658072), transcript variant X4, mRNA -- -- -- -- Q5FWS6 754 6.6e-78 Kazrin OS=Rattus norvegicus GN=Kazn PE=2 SV=2 PF02183//PF04923//PF07647//PF14010//PF00536//PF09482//PF12285 Homeobox associated leucine zipper//Ninjurin//SAM domain (Sterile alpha motif)//Phosphoenolpyruvate carboxylase//SAM domain (Sterile alpha motif)//Bacterial type III secretion apparatus protein (OrgA_MxiK)//Protein of unknown function (DUF3621) GO:0006094//GO:0006355//GO:0006099//GO:0009405//GO:0007155//GO:0042246//GO:0019643//GO:0015977 gluconeogenesis//regulation of transcription, DNA-templated//tricarboxylic acid cycle//pathogenesis//cell adhesion//tissue regeneration//reductive tricarboxylic acid cycle//carbon fixation GO:0003700//GO:0004252//GO:0043565//GO:0008964//GO:0070008//GO:0005515 transcription factor activity, sequence-specific DNA binding//serine-type endopeptidase activity//sequence-specific DNA binding//phosphoenolpyruvate carboxylase activity//serine-type exopeptidase activity//protein binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.19734 BP_3 13.00 0.31 2308 607357226 EZA51692.1 238 3.8e-17 Acetylcholine receptor subunit alpha-like protein [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19736 BP_3 52.00 1.79 1689 332372586 AEE61435.1 925 6.0e-97 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15109 SLC25A20_29, CACT, CACL, CRC1 solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter), member 20/29 http://www.genome.jp/dbget-bin/www_bget?ko:K15109 Q08DK7 613 3.7e-62 Mitochondrial basic amino acids transporter OS=Bos taurus GN=SLC25A29 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0758 Mitochondrial carnitine-acylcarnitine carrier protein Cluster-8309.19737 BP_3 20.15 0.46 2425 642938529 XP_967703.2 1839 9.0e-203 PREDICTED: RUN domain-containing protein 1-like [Tribolium castaneum]>gi|270015593|gb|EFA12041.1| hypothetical protein TcasGA2_TC001458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96C34 722 1.2e-74 RUN domain-containing protein 1 OS=Homo sapiens GN=RUNDC1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3759 Uncharacterized RUN domain protein Cluster-8309.19739 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19744 BP_3 361.46 12.07 1735 91080479 XP_970655.1 1220 3.8e-131 PREDICTED: peroxisomal membrane protein PEX16 [Tribolium castaneum]>gi|270005559|gb|EFA02007.1| hypothetical protein TcasGA2_TC007629 [Tribolium castaneum] -- -- -- -- -- K13335 PEX16 peroxin-16 http://www.genome.jp/dbget-bin/www_bget?ko:K13335 Q4QRH7 645 7.5e-66 Peroxisomal membrane protein PEX16 OS=Danio rerio GN=pex16 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19745 BP_3 36.60 0.89 2278 642925556 XP_971635.2 645 2.4e-64 PREDICTED: estrogen sulfotransferase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52845 368 1.3e-33 Estrogen sulfotransferase, isoform 2 OS=Rattus norvegicus GN=Ste2 PE=2 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.19746 BP_3 24.77 0.33 3948 389609119 BAM18171.1 379 2.9e-33 sulfotransferase [Papilio xuthus] -- -- -- -- -- -- -- -- -- Q95JD5 253 4.9e-20 Sulfotransferase family cytosolic 1B member 1 OS=Canis familiaris GN=SULT1B1 PE=1 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- KOG1584 Sulfotransferase Cluster-8309.19748 BP_3 11.04 0.75 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19749 BP_3 70.46 3.59 1239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19750 BP_3 1.02 4.68 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19751 BP_3 26.49 1.41 1197 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19753 BP_3 32.74 1.69 1223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19754 BP_3 13.00 0.78 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19755 BP_3 48.56 2.08 1417 260807253 XP_002598423.1 302 8.8e-25 hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae]>gi|229283696|gb|EEN54435.1| hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9NPA5 202 1.4e-14 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF07776//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.19757 BP_3 16.56 0.95 1133 270006684 EFA03132.1 732 9.7e-75 hypothetical protein TcasGA2_TC013044 [Tribolium castaneum] 642924851 XM_008195844.1 184 2.61402e-89 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- Q9Y266 547 1.1e-54 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.19763 BP_3 11.00 0.56 1233 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19765 BP_3 3.00 0.53 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19771 BP_3 44.57 1.75 1516 91087975 XP_973241.1 1095 1.0e-116 PREDICTED: wiskott-Aldrich syndrome protein family member 3 [Tribolium castaneum]>gi|270012052|gb|EFA08500.1| hypothetical protein TcasGA2_TC006152 [Tribolium castaneum] -- -- -- -- -- K06220 WASF WAS protein family http://www.genome.jp/dbget-bin/www_bget?ko:K06220 Q9UPY6 601 8.3e-61 Wiskott-Aldrich syndrome protein family member 3 OS=Homo sapiens GN=WASF3 PE=1 SV=2 PF03358//PF07415 NADPH-dependent FMN reductase//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency GO:0003779//GO:0016491 actin binding//oxidoreductase activity GO:0033644 host cell membrane KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.19773 BP_3 6.00 1.56 477 270014998 EFA11446.1 264 7.5e-21 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.19774 BP_3 44.90 1.12 2228 91086413 XP_967009.1 1442 8.9e-157 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270010301|gb|EFA06749.1| hypothetical protein TcasGA2_TC009683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MYA4 555 2.6e-55 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.19778 BP_3 368.00 11.14 1884 642928879 XP_008195599.1 1557 3.5e-170 PREDICTED: uncharacterized protein F21D5.5 [Tribolium castaneum]>gi|642928881|ref|XP_008195600.1| PREDICTED: uncharacterized protein F21D5.5 [Tribolium castaneum]>gi|270009738|gb|EFA06186.1| hypothetical protein TcasGA2_TC009034 [Tribolium castaneum] -- -- -- -- -- K08073 PNKP bifunctional polynucleotide phosphatase/kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08073 Q96T60 896 6.4e-95 Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens GN=PNKP PE=1 SV=1 PF00910//PF06414//PF03601 RNA helicase//Zeta toxin//Conserved hypothetical protein 698 -- -- GO:0003724//GO:0016301//GO:0005524//GO:0003723 RNA helicase activity//kinase activity//ATP binding//RNA binding GO:0016021 integral component of membrane KOG2134 Polynucleotide kinase 3' phosphatase Cluster-8309.19779 BP_3 504.65 12.23 2280 270010353 EFA06801.1 1544 1.4e-168 hypothetical protein TcasGA2_TC009740 [Tribolium castaneum] 665795469 XM_008547261.1 239 1.42252e-119 PREDICTED: Microplitis demolitor cyclin-dependent kinase 5 (LOC103569778), mRNA K02090 CDK5 cyclin-dependent kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02090 P51166 1313 3.4e-143 Cyclin-dependent-like kinase 5 OS=Xenopus laevis GN=cdk5 PE=2 SV=1 PF02109//PF07714//PF00069 DAD family//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0018279 protein phosphorylation//protein N-linked glycosylation via asparagine GO:0005524//GO:0004579//GO:0004672 ATP binding//dolichyl-diphosphooligosaccharide-protein glycotransferase activity//protein kinase activity GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.19781 BP_3 375.40 10.53 2010 642917401 XP_008191181.1 1711 5.2e-188 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like [Tribolium castaneum] 167777849 CP000786.1 38 6.80291e-08 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome I, complete sequence -- -- -- -- A1L258 1469 2.5e-161 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF02913//PF01565 FAD linked oxidases, C-terminal domain//FAD binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0050660//GO:0003824 oxidoreductase activity//flavin adenine dinucleotide binding//catalytic activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.19784 BP_3 5.00 0.46 815 817087870 XP_012266730.1 217 3.6e-15 PREDICTED: uncharacterized protein LOC105692236 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19785 BP_3 18.00 1.97 732 817087870 XP_012266730.1 217 3.3e-15 PREDICTED: uncharacterized protein LOC105692236 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19787 BP_3 52.24 0.86 3215 861634002 KMQ91126.1 968 1.2e-101 dna pol b2 domain-containing protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04574//PF09198 Protein of unknown function (DUF592)//Bacteriophage T4 beta-glucosyltransferase GO:0006807//GO:0006304//GO:0006355//GO:0006476//GO:0006342 nitrogen compound metabolic process//DNA modification//regulation of transcription, DNA-templated//protein deacetylation//chromatin silencing GO:0008270//GO:0033821//GO:0017136//GO:0051287//GO:0016811 zinc ion binding//DNA beta-glucosyltransferase activity//NAD-dependent histone deacetylase activity//NAD binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0000118 histone deacetylase complex -- -- Cluster-8309.19791 BP_3 632.25 25.20 1501 642914715 XP_008199944.1 1273 2.4e-137 PREDICTED: BTB/POZ domain-containing protein kctd15-like [Tribolium castaneum] 642914714 XM_008201722.1 359 0 PREDICTED: Tribolium castaneum BTB/POZ domain-containing protein kctd15-like (LOC654911), mRNA -- -- -- -- Q8K0E1 655 4.5e-67 BTB/POZ domain-containing protein KCTD15 OS=Mus musculus GN=Kctd15 PE=1 SV=1 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.19795 BP_3 16.00 1.95 688 641650452 XP_008189623.1 219 1.8e-15 PREDICTED: uncharacterized protein LOC103311703 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19800 BP_3 89.00 3.68 1458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19805 BP_3 255.01 21.59 861 546681999 ERL91995.1 545 3.5e-53 hypothetical protein D910_09317 [Dendroctonus ponderosae] -- -- -- -- -- K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 354 2.1e-32 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF11910//PF16499 Cyanobacterial and plant NDH-1 subunit O//Alpha galactosidase A GO:0006118//GO:0005975//GO:0055114 obsolete electron transport//carbohydrate metabolic process//oxidation-reduction process GO:0004553//GO:0016655 hydrolase activity, hydrolyzing O-glycosyl compounds//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005886 plasma membrane KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.19806 BP_3 44.03 2.54 1128 332374122 AEE62202.1 734 5.6e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9D0I8 597 1.8e-60 mRNA turnover protein 4 homolog OS=Mus musculus GN=Mrto4 PE=2 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.19807 BP_3 32.01 0.41 4013 642924494 XP_008194318.1 1947 4.5e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 1.0e-105 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF04452//PF00829 RNA methyltransferase//Ribosomal prokaryotic L21 protein GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.19808 BP_3 11.65 0.34 1957 861605580 KMQ84383.1 273 2.8e-21 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1981 BP_3 35.94 1.42 1516 676433751 XP_009047002.1 449 8.5e-42 hypothetical protein LOTGIDRAFT_54048, partial [Lottia gigantea]>gi|556113642|gb|ESP02294.1| hypothetical protein LOTGIDRAFT_54048, partial [Lottia gigantea] -- -- -- -- -- K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O35598 350 1.1e-31 Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus GN=Adam10 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.19811 BP_3 2.00 0.75 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19814 BP_3 18.00 0.66 1614 478257935 ENN78073.1 144 2.1e-06 hypothetical protein YQE_05227, partial [Dendroctonus ponderosae] 462344970 APGK01034847.1 56 5.36247e-18 Dendroctonus ponderosae Seq01034857, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19820 BP_3 95.90 1.11 4462 91087237 XP_975509.1 1259 3.0e-135 PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|642929695|ref|XP_008195939.1| PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|270010578|gb|EFA07026.1| hypothetical protein TcasGA2_TC009997 [Tribolium castaneum] 827564585 CP011663.1 41 3.27576e-09 Clostridium sporogenes strain DSM 795, complete genome K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 1035 1.2e-110 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF16834//PF00490//PF03244 Shu complex component Csm2, DNA-binding//Delta-aminolevulinic acid dehydratase//Photosystem I reaction centre subunit VI GO:0000725//GO:0033014//GO:0015994//GO:0015979 recombinational repair//tetrapyrrole biosynthetic process//chlorophyll metabolic process//photosynthesis GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding GO:0009538//GO:0097196//GO:0009522//GO:0005634 photosystem I reaction center//Shu complex//photosystem I//nucleus KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.19822 BP_3 5.31 0.56 751 91083531 XP_973193.1 329 3.4e-28 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q3SZD7 245 7.8e-20 Carbonyl reductase [NADPH] 1 OS=Bos taurus GN=CBR1 PE=2 SV=1 -- -- GO:0008152 metabolic process -- -- -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.19824 BP_3 16.00 1.80 721 16903179 AAK61417.1 621 4.6e-62 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19825 BP_3 35.01 0.71 2664 642919019 XP_008191698.1 900 7.5e-94 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P1I3 328 6.6e-29 UPF0536 protein C12orf66 homolog OS=Mus musculus PE=1 SV=1 PF15234 Linker for activation of T-cells GO:0007165 signal transduction -- -- GO:0016020 membrane -- -- Cluster-8309.19826 BP_3 130.00 11.47 838 91083983 XP_975195.1 539 1.7e-52 PREDICTED: 39S ribosomal protein L20, mitochondrial [Tribolium castaneum]>gi|270006712|gb|EFA03160.1| hypothetical protein TcasGA2_TC013079 [Tribolium castaneum] -- -- -- -- -- K02887 RP-L20, MRPL20, rplT large subunit ribosomal protein L20 http://www.genome.jp/dbget-bin/www_bget?ko:K02887 Q5U4Z8 307 5.6e-27 39S ribosomal protein L20, mitochondrial OS=Xenopus laevis GN=mrpl20 PE=2 SV=1 PF00453 Ribosomal protein L20 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005622//GO:0005840 intracellular//ribosome KOG4707 Mitochondrial/chloroplast ribosomal protein L20 Cluster-8309.19827 BP_3 5.00 0.33 1024 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19828 BP_3 11.82 0.39 1766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04272 Phospholamban GO:0006816//GO:0006810 calcium ion transport//transport GO:0005246//GO:0042030 calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.19829 BP_3 45.90 0.87 2833 91078378 XP_974191.1 2129 2.5e-236 PREDICTED: probable leucine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270003885|gb|EFA00333.1| hypothetical protein TcasGA2_TC003172 [Tribolium castaneum] -- -- -- -- -- K01869 LARS, leuS leucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01869 Q5RDP4 1433 5.2e-157 Probable leucine--tRNA ligase, mitochondrial OS=Pongo abelii GN=LARS2 PE=2 SV=1 PF13603//PF03119//PF08264//PF09334//PF00133 Leucyl-tRNA synthetase, Domain 2//NAD-dependent DNA ligase C4 zinc finger domain//Anticodon-binding domain of tRNA//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V) GO:0009098//GO:0009097//GO:0006281//GO:0006418//GO:0006260//GO:0006429//GO:0006450//GO:0009099 leucine biosynthetic process//isoleucine biosynthetic process//DNA repair//tRNA aminoacylation for protein translation//DNA replication//leucyl-tRNA aminoacylation//regulation of translational fidelity//valine biosynthetic process GO:0003911//GO:0005524//GO:0004823//GO:0000166//GO:0004812//GO:0002161 DNA ligase (NAD+) activity//ATP binding//leucine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity GO:0005737 cytoplasm KOG0435 Leucyl-tRNA synthetase Cluster-8309.1983 BP_3 11.00 0.43 1519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19830 BP_3 9.72 0.54 1161 646722316 KDR23329.1 193 3.1e-12 DNA repair protein RAD51-like protein 3 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8GXF0 158 1.5e-09 DNA repair protein RAD51 homolog 3 OS=Arabidopsis thaliana GN=RAD51C PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1433 DNA repair protein RAD51/RHP55 Cluster-8309.19835 BP_3 1096.11 25.25 2384 478256682 ENN76864.1 1389 1.3e-150 hypothetical protein YQE_06705, partial [Dendroctonus ponderosae]>gi|546685121|gb|ERL94648.1| hypothetical protein D910_11923 [Dendroctonus ponderosae] -- -- -- -- -- K01792 E5.1.3.15 glucose-6-phosphate 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01792 Q03161 400 2.6e-37 Glucose-6-phosphate 1-epimerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMR099C PE=1 SV=1 PF05197//PF01263 TRIC channel//Aldose 1-epimerase GO:0015672//GO:0006812//GO:0005975 monovalent inorganic cation transport//cation transport//carbohydrate metabolic process GO:0005261//GO:0016853 cation channel activity//isomerase activity GO:0016020 membrane KOG1594 Uncharacterized enzymes related to aldose 1-epimerase Cluster-8309.19838 BP_3 44.44 3.48 907 270002738 EEZ99185.1 595 6.0e-59 serine protease H6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BLP6 245 9.4e-20 AT-rich interactive domain-containing protein 5B OS=Bos taurus GN=ARID5B PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19839 BP_3 44.08 0.40 5613 642911114 XP_008200584.1 4519 0.0e+00 PREDICTED: tyrosine-protein phosphatase 99A [Tribolium castaneum] 195445683 XM_002070402.1 103 1.41283e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2407 1.2e-269 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF16656//PF00102//PF00041//PF00782 Purple acid Phosphatase, N-terminal domain//Protein-tyrosine phosphatase//Fibronectin type III domain//Dual specificity phosphatase, catalytic domain GO:0006771//GO:0006470//GO:0006570//GO:0019497 riboflavin metabolic process//protein dephosphorylation//tyrosine metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0008138//GO:0005515//GO:0004725 acid phosphatase activity//metal ion binding//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.19840 BP_3 64.36 0.70 4737 270014603 EFA11051.1 3351 0.0e+00 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] 195445683 XM_002070402.1 103 1.19091e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2271 5.8e-254 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00782//PF00102//PF00041 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Fibronectin type III domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0005515//GO:0008138//GO:0004725 protein binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.19842 BP_3 6.00 2.95 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19845 BP_3 103.44 1.25 4282 642920192 XP_008192242.1 2078 3.1e-230 PREDICTED: REST corepressor [Tribolium castaneum] 817199620 XM_012420083.1 130 1.05306e-58 PREDICTED: Orussus abietinus uncharacterized LOC105697085 (LOC105697085), transcript variant X3, mRNA -- -- -- -- Q6P116 901 3.8e-95 REST corepressor 2 OS=Danio rerio GN=rcor2 PE=2 SV=1 PF04977//PF00320//PF00376 Septum formation initiator//GATA zinc finger//MerR family regulatory protein GO:0006355//GO:0007049 regulation of transcription, DNA-templated//cell cycle GO:0003677//GO:0008270//GO:0043565//GO:0003700 DNA binding//zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1194 Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains Cluster-8309.19849 BP_3 74.53 0.42 8753 91094617 XP_968941.1 1952 2.6e-215 PREDICTED: NEDD4-binding protein 2 [Tribolium castaneum]>gi|270016434|gb|EFA12880.1| hypothetical protein TcasGA2_TC011558 [Tribolium castaneum] -- -- -- -- -- K08830 RAGE, MOK renal tumor antigen http://www.genome.jp/dbget-bin/www_bget?ko:K08830 Q9UQ07 493 1.6e-47 MAPK/MAK/MRK overlapping kinase OS=Homo sapiens GN=MOK PE=2 SV=1 PF09138//PF08120//PF07714//PF06414//PF02845//PF00069//PF06293 Urm1 (Ubiquitin related modifier)//Tamulustoxin family//Protein tyrosine kinase//Zeta toxin//CUE domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006810//GO:0006468//GO:0034227//GO:0009405 transport//protein phosphorylation//tRNA thio-modification//pathogenesis GO:0004672//GO:0016301//GO:0016773//GO:0005515//GO:0019870//GO:0005524 protein kinase activity//kinase activity//phosphotransferase activity, alcohol group as acceptor//protein binding//potassium channel inhibitor activity//ATP binding GO:0005737//GO:0016020//GO:0005576 cytoplasm//membrane//extracellular region KOG0661 MAPK related serine/threonine protein kinase Cluster-8309.19850 BP_3 963.44 13.01 3860 91094617 XP_968941.1 1978 1.1e-218 PREDICTED: NEDD4-binding protein 2 [Tribolium castaneum]>gi|270016434|gb|EFA12880.1| hypothetical protein TcasGA2_TC011558 [Tribolium castaneum] -- -- -- -- -- K15720 N4BP2 NEDD4-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15720 Q92802 379 1.2e-34 NEDD4-binding protein 2-like 2 OS=Homo sapiens GN=N4BP2L2 PE=1 SV=1 PF01234//PF06414//PF02845 NNMT/PNMT/TEMT family//Zeta toxin//CUE domain -- -- GO:0005515//GO:0016301//GO:0008168//GO:0005524 protein binding//kinase activity//methyltransferase activity//ATP binding -- -- KOG2401 Predicted MutS-related protein involved in mismatch repair Cluster-8309.19854 BP_3 136.78 1.50 4695 390362249 XP_001190749.2 1582 1.1e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 2.6e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF08100//PF00906//PF13606//PF00023//PF00866//PF04069 Dimerisation domain//Hepatitis core antigen//Ankyrin repeat//Ankyrin repeat//Ring hydroxylating beta subunit//Substrate binding domain of ABC-type glycine betaine transport system GO:0006725//GO:0055114//GO:0006810//GO:0009405 cellular aromatic compound metabolic process//oxidation-reduction process//transport//pathogenesis GO:0005515//GO:0046983//GO:0005215//GO:0005198//GO:0003824 protein binding//protein dimerization activity//transporter activity//structural molecule activity//catalytic activity -- -- -- -- Cluster-8309.19857 BP_3 31.09 0.72 2366 91080889 XP_973062.1 2522 5.5e-282 PREDICTED: ER degradation-enhancing alpha-mannosidase-like protein 2 [Tribolium castaneum]>gi|270005396|gb|EFA01844.1| hypothetical protein TcasGA2_TC007447 [Tribolium castaneum] 462316750 APGK01044966.1 63 1.01683e-21 Dendroctonus ponderosae Seq01044976, whole genome shotgun sequence K10085 EDEM2 ER degradation enhancer, mannosidase alpha-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10085 Q9BV94 1602 1.1e-176 ER degradation-enhancing alpha-mannosidase-like protein 2 OS=Homo sapiens GN=EDEM2 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2429 Glycosyl hydrolase, family 47 Cluster-8309.19858 BP_3 1343.78 32.54 2282 91080889 XP_973062.1 2602 2.8e-291 PREDICTED: ER degradation-enhancing alpha-mannosidase-like protein 2 [Tribolium castaneum]>gi|270005396|gb|EFA01844.1| hypothetical protein TcasGA2_TC007447 [Tribolium castaneum] 462316750 APGK01044966.1 63 9.80183e-22 Dendroctonus ponderosae Seq01044976, whole genome shotgun sequence K10085 EDEM2 ER degradation enhancer, mannosidase alpha-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10085 Q9BV94 1655 7.5e-183 ER degradation-enhancing alpha-mannosidase-like protein 2 OS=Homo sapiens GN=EDEM2 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2429 Glycosyl hydrolase, family 47 Cluster-8309.19862 BP_3 426.06 11.65 2055 91076222 XP_972737.1 1328 1.4e-143 PREDICTED: protein phosphatase methylesterase 1 [Tribolium castaneum]>gi|270014549|gb|EFA10997.1| hypothetical protein TcasGA2_TC004582 [Tribolium castaneum] -- -- -- -- -- K13617 PPME1 protein phosphatase methylesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13617 Q8BVQ5 851 1.2e-89 Protein phosphatase methylesterase 1 OS=Mus musculus GN=Ppme1 PE=1 SV=5 PF00975//PF07859//PF07819//PF12740//PF01764 Thioesterase domain//alpha/beta hydrolase fold//PGAP1-like protein//Chlorophyllase enzyme//Lipase (class 3) GO:0015996//GO:0006505//GO:0008152//GO:0006629//GO:0006886//GO:0015994//GO:0009058 chlorophyll catabolic process//GPI anchor metabolic process//metabolic process//lipid metabolic process//intracellular protein transport//chlorophyll metabolic process//biosynthetic process GO:0016787//GO:0016788//GO:0047746 hydrolase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity -- -- KOG2564 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold Cluster-8309.19863 BP_3 573.40 4.86 5980 642920211 XP_008192250.1 2586 5.3e-289 PREDICTED: LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11 [Tribolium castaneum] 721631354 XM_003567893.2 45 2.629e-11 PREDICTED: Brachypodium distachyon mannose-6-phosphate isomerase 1 (LOC100835530), mRNA K11273 DDX11, CHL1, CTF1 chromosome transmission fidelity protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11273 Q92771 1452 6.8e-159 Putative ATP-dependent RNA helicase DDX12 OS=Homo sapiens GN=DDX12P PE=5 SV=3 PF01416//PF04851//PF02562//PF08471//PF06733//PF02944//PF01238//PF00170//PF13307 tRNA pseudouridine synthase//Type III restriction enzyme, res subunit//PhoH-like protein//Class II vitamin B12-dependent ribonucleotide reductase//DEAD_2//BESS motif//Phosphomannose isomerase type I//bZIP transcription factor//Helicase C-terminal domain GO:0006139//GO:0006355//GO:0001522//GO:0055114//GO:0005975//GO:0006000//GO:0009186//GO:0006144//GO:0006206//GO:0009451//GO:0006013 nucleobase-containing compound metabolic process//regulation of transcription, DNA-templated//pseudouridine synthesis//oxidation-reduction process//carbohydrate metabolic process//fructose metabolic process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//RNA modification//mannose metabolic process GO:0005524//GO:0016787//GO:0004476//GO:0008270//GO:0043565//GO:0009982//GO:0004003//GO:0003700//GO:0050897//GO:0016818//GO:0003723//GO:0003677//GO:0008026//GO:0004748//GO:0003676 ATP binding//hydrolase activity//mannose-6-phosphate isomerase activity//zinc ion binding//sequence-specific DNA binding//pseudouridine synthase activity//ATP-dependent DNA helicase activity//transcription factor activity, sequence-specific DNA binding//cobalt ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//RNA binding//DNA binding//ATP-dependent helicase activity//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//nucleic acid binding GO:0005657//GO:0005667//GO:0005971 replication fork//transcription factor complex//ribonucleoside-diphosphate reductase complex KOG1133 Helicase of the DEAD superfamily Cluster-8309.19864 BP_3 911.46 20.27 2459 189239355 XP_974286.2 3169 0.0e+00 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 2546 3.9e-286 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 PF00622//PF00270 SPRY domain//DEAD/DEAH box helicase -- -- GO:0008026//GO:0005515//GO:0005524//GO:0003676 ATP-dependent helicase activity//protein binding//ATP binding//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.19867 BP_3 94.71 1.87 2735 728418413 AIY68368.1 1496 6.0e-163 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 543 7.9e-54 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859//PF01691 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Adenovirus E1B 19K protein / small t-antigen GO:0006508//GO:0008152//GO:0043066 proteolysis//metabolic process//negative regulation of apoptotic process GO:0016787//GO:0005521//GO:0008236 hydrolase activity//lamin binding//serine-type peptidase activity -- -- -- -- Cluster-8309.19869 BP_3 197.42 4.30 2507 642910817 XP_008193421.1 1463 3.7e-159 PREDICTED: rab11 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 9.9e-27 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19871 BP_3 7.00 0.61 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19874 BP_3 12.00 0.94 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19876 BP_3 4.00 0.33 881 195499002 XP_002087146.1 258 6.9e-20 GE14720 [Drosophila yakuba]>gi|194186817|gb|EDX00429.1| GE14720 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.19878 BP_3 4.00 0.86 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19879 BP_3 778.03 5.97 6572 642925278 XP_008194489.1 2317 9.1e-258 PREDICTED: PAX-interacting protein 1 [Tribolium castaneum]>gi|270009278|gb|EFA05726.1| hypothetical protein TcasGA2_TC015410 [Tribolium castaneum] -- -- -- -- -- K14972 PAXIP1, PTIP PAX-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14972 A0JNA8 692 1.0e-70 PAX-interacting protein 1 OS=Bos taurus GN=PAXIP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.19880 BP_3 44.30 0.46 4937 546674399 ERL85786.1 1035 3.1e-109 hypothetical protein D910_03201 [Dendroctonus ponderosae] -- -- -- -- -- K14972 PAXIP1, PTIP PAX-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14972 Q5XIY8 339 6.5e-30 PAX-interacting protein 1 OS=Danio rerio GN=paxip1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.19889 BP_3 882.32 9.25 4888 642927783 XP_008195404.1 4878 0.0e+00 PREDICTED: eukaryotic translation initiation factor 2-alpha kinase 4 [Tribolium castaneum]>gi|270009882|gb|EFA06330.1| hypothetical protein TcasGA2_TC009201 [Tribolium castaneum] -- -- -- -- -- K16196 EIF2AK4 eukaryotic translation initiation factor 2-alpha kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16196 Q9P2K8 2284 1.9e-255 Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 PF00069//PF05773//PF07714 Protein kinase domain//RWD domain//Protein tyrosine kinase GO:0044267//GO:0016310//GO:0006468//GO:0009069 cellular protein metabolic process//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0000166//GO:0005515//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//nucleotide binding//protein binding//ATP binding -- -- KOG1035 eIF-2alpha kinase GCN2 Cluster-8309.19891 BP_3 43.20 4.37 768 91083069 XP_967587.1 495 2.0e-47 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q0KI50 245 8.0e-20 Dystrophin, isoform D OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF02183//PF02601//PF04977//PF14073//PF04632//PF13851//PF10473//PF01166//PF11802//PF11365//PF07716//PF08826//PF16473//PF04065//PF06156//PF04111//PF04871//PF00170//PF10186//PF06005 Homeobox associated leucine zipper//Exonuclease VII, large subunit//Septum formation initiator//Centrosome localisation domain of Cep57//Fusaric acid resistance protein family//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TSC-22/dip/bun family//Centromere-associated protein K//Protein of unknown function (DUF3166)//Basic region leucine zipper//DMPK coiled coil domain like//Domain of unknown function (DUF5051)//Not1 N-terminal domain, CCR4-Not complex component//Protein of unknown function (DUF972)//Autophagy protein Apg6//Uso1 / p115 like vesicle tethering protein, C terminal region//bZIP transcription factor//Vacuolar sorting 38 and autophagy-related subunit 14//Protein of unknown function (DUF904) GO:0000917//GO:0043093//GO:0006308//GO:0006886//GO:0006810//GO:0006468//GO:0006914//GO:0009069//GO:0015031//GO:0007049//GO:0010508//GO:0006355//GO:0048870//GO:0016310//GO:0010506//GO:0006260 barrier septum assembly//FtsZ-dependent cytokinesis//DNA catabolic process//intracellular protein transport//transport//protein phosphorylation//autophagy//serine family amino acid metabolic process//protein transport//cell cycle//positive regulation of autophagy//regulation of transcription, DNA-templated//cell motility//phosphorylation//regulation of autophagy//DNA replication GO:0008855//GO:0042802//GO:0043015//GO:0042803//GO:0008565//GO:0043565//GO:0003676//GO:0043169//GO:0008134//GO:0045502//GO:0005524//GO:0004674//GO:0003700 exodeoxyribonuclease VII activity//identical protein binding//gamma-tubulin binding//protein homodimerization activity//protein transporter activity//sequence-specific DNA binding//nucleic acid binding//cation binding//transcription factor binding//dynein binding//ATP binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding GO:0005886//GO:0005634//GO:0016020//GO:0031514//GO:0005737//GO:0005667//GO:0030286//GO:0045298//GO:0005615//GO:0009318 plasma membrane//nucleus//membrane//motile cilium//cytoplasm//transcription factor complex//dynein complex//tubulin complex//extracellular space//exodeoxyribonuclease VII complex -- -- Cluster-8309.19892 BP_3 1.66 0.93 375 571551140 XP_006567634.1 157 1.5e-08 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like isoform X95 [Apis mellifera] -- -- -- -- -- -- -- -- -- Q7KQZ4 123 5.4e-06 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF02176//PF00096//PF17123//PF13639//PF13465//PF16622//PF02892//PF13912 TRAF-type zinc finger//Zinc finger, C2H2 type//RING-like zinc finger//Ring finger domain//Zinc-finger double domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0005515//GO:0046872//GO:0008270//GO:0003677 protein binding//metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.19893 BP_3 177.33 2.74 3416 642937039 XP_008198663.1 2804 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X4 [Tribolium castaneum] 501300159 AK418404.1 119 1.09208e-52 Riptortus pedestris mRNA for cytoplasmic dynein intermediate chain, partial cds, sequence id: Rped-0877, expressed in midgut K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 2006 2.2e-223 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF00400//PF09266//PF11540 WD domain, G-beta repeat//Viral DNA topoisomerase I, N-terminal//Cytoplasmic dynein 1 intermediate chain 2 GO:0007018//GO:0006265 microtubule-based movement//DNA topological change GO:0003677//GO:0005515//GO:0003916 DNA binding//protein binding//DNA topoisomerase activity GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.19899 BP_3 51.44 0.46 5687 478252232 ENN72660.1 959 2.3e-100 hypothetical protein YQE_10758, partial [Dendroctonus ponderosae] -- -- -- -- -- K10732 GINS1, PSF1 GINS complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10732 Q14691 446 2.9e-42 DNA replication complex GINS protein PSF1 OS=Homo sapiens GN=GINS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3303 Predicted alpha-helical protein, potentially involved in replication/repair Cluster-8309.1990 BP_3 16.37 0.60 1600 170062970 XP_001866901.1 286 7.1e-23 Gly-rich protein [Culex quinquefasciatus]>gi|167880749|gb|EDS44132.1| Gly-rich protein [Culex quinquefasciatus] 751774435 XM_011215544.1 86 1.11838e-34 PREDICTED: Bactrocera dorsalis glycine-rich cell wall structural protein (LOC105233452), mRNA -- -- -- -- -- -- -- -- PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19900 BP_3 27.04 0.42 3384 478255416 ENN75638.1 1298 6.8e-140 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 987 3.2e-105 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 PF00288//PF04627 GHMP kinases N terminal domain//Mitochondrial ATP synthase epsilon chain GO:0006119//GO:0015986//GO:0015992 oxidative phosphorylation//ATP synthesis coupled proton transport//proton transport GO:0005524//GO:0046933//GO:0046961 ATP binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.19901 BP_3 10.00 0.87 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19903 BP_3 532.27 16.71 1827 332373656 AEE61969.1 1637 1.8e-179 unknown [Dendroctonus ponderosae] 571430507 KF255600.1 388 0 Plutella xylostella protein phosphatase 4 mRNA, complete cds K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 Q5R6K8 1586 6.0e-175 Serine/threonine-protein phosphatase 4 catalytic subunit OS=Pongo abelii GN=PPP4C PE=2 SV=1 PF01429//PF00149 Methyl-CpG binding domain//Calcineurin-like phosphoesterase -- -- GO:0016787//GO:0003677 hydrolase activity//DNA binding GO:0005634 nucleus KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-8309.19904 BP_3 421.00 14.21 1720 642929591 XP_008195896.1 1048 3.3e-111 PREDICTED: protein LTV1 homolog [Tribolium castaneum]>gi|270010989|gb|EFA07437.1| hypothetical protein TcasGA2_TC008848 [Tribolium castaneum] -- -- -- -- -- K14798 LTV1 protein LTV1 http://www.genome.jp/dbget-bin/www_bget?ko:K14798 Q4V838 689 5.9e-71 Protein LTV1 homolog OS=Xenopus laevis GN=ltv1 PE=2 SV=1 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- KOG2637 Uncharacterized conserved protein Cluster-8309.19907 BP_3 16.00 2.45 606 642928567 XP_008199961.1 527 3.0e-51 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 461 5.6e-45 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.19910 BP_3 74.00 2.78 1573 642922501 XP_008193198.1 1020 5.4e-108 PREDICTED: uncharacterized protein LOC103312982 [Tribolium castaneum]>gi|270007489|gb|EFA03937.1| hypothetical protein TcasGA2_TC014078 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19913 BP_3 12.00 3.99 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19915 BP_3 9.00 0.38 1419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19917 BP_3 186.47 2.58 3778 478253846 ENN74138.1 253 1.1e-18 hypothetical protein YQE_09111, partial [Dendroctonus ponderosae]>gi|546684652|gb|ERL94269.1| hypothetical protein D910_11550, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19921 BP_3 92.00 6.08 1021 478252450 ENN72872.1 369 1.1e-32 hypothetical protein YQE_10442, partial [Dendroctonus ponderosae]>gi|546685970|gb|ERL95381.1| hypothetical protein D910_12645 [Dendroctonus ponderosae] -- -- -- -- -- K18170 LYRM7, MZM1 complex III assembly factor LYRM7 http://www.genome.jp/dbget-bin/www_bget?ko:K18170 A5PLG0 212 7.1e-16 Complex III assembly factor LYRM7 OS=Danio rerio GN=LYRM7 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19925 BP_3 45.67 0.58 4068 270012188 EFA08636.1 1740 4.5e-191 hypothetical protein TcasGA2_TC006299 [Tribolium castaneum] -- -- -- -- -- K08803 DAPK death-associated protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08803 O44997 489 2.2e-47 Death-associated protein kinase dapk-1 OS=Caenorhabditis elegans GN=dapk-1 PE=2 SV=2 PF00531//PF13508//PF00583//PF04558 Death domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 GO:0042967//GO:0007165//GO:0006418 acyl-carrier-protein biosynthetic process//signal transduction//tRNA aminoacylation for protein translation GO:0008080//GO:0005515//GO:0005524//GO:0004812//GO:0000166 N-acetyltransferase activity//protein binding//ATP binding//aminoacyl-tRNA ligase activity//nucleotide binding GO:0005737 cytoplasm -- -- Cluster-8309.19926 BP_3 1.00 1.37 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19928 BP_3 1.00 0.39 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19929 BP_3 1.00 0.36 426 270014998 EFA11446.1 249 3.7e-19 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.1993 BP_3 12.08 0.39 1778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19932 BP_3 17.84 3.12 567 270014998 EFA11446.1 390 2.2e-35 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8GUQ8 156 1.2e-09 Xanthine dehydrogenase 1 OS=Arabidopsis thaliana GN=XDH1 PE=1 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19933 BP_3 1.00 0.35 430 270014998 EFA11446.1 219 1.1e-15 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.19936 BP_3 39.36 5.58 632 91094767 XP_967707.1 608 1.3e-60 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- K00157 AOX aldehyde oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00157 P80457 356 8.8e-33 Xanthine dehydrogenase/oxidase OS=Bos taurus GN=XDH PE=1 SV=4 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0003824//GO:0043167 oxidoreductase activity//catalytic activity//ion binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19937 BP_3 1.16 1.10 335 270014998 EFA11446.1 335 3.1e-29 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 Q8GUQ8 140 5.2e-08 Xanthine dehydrogenase 1 OS=Arabidopsis thaliana GN=XDH1 PE=1 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.1994 BP_3 8.41 0.34 1495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF05091 THAP domain//Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) GO:0006446 regulation of translational initiation GO:0003676//GO:0003743 nucleic acid binding//translation initiation factor activity GO:0005737//GO:0005852//GO:0005840 cytoplasm//eukaryotic translation initiation factor 3 complex//ribosome -- -- Cluster-8309.19944 BP_3 8.30 0.35 1448 91094767 XP_967707.1 549 2.1e-53 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5QE79 333 9.4e-30 Aldehyde oxidase 4 OS=Rattus norvegicus GN=Aox4 PE=2 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0043167//GO:0003824 oxidoreductase activity//ion binding//catalytic activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.1995 BP_3 58.06 2.09 1631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19957 BP_3 33.83 1.86 1170 514683686 XP_004989424.1 263 2.4e-20 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- P52746 196 5.9e-14 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF02150//PF01096//PF13465//PF00569//PF00096 RNA polymerases M/15 Kd subunit//Transcription factor S-II (TFIIS)//Zinc-finger double domain//Zinc finger, ZZ type//Zinc finger, C2H2 type GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003676//GO:0008270//GO:0046872//GO:0003677//GO:0003899 nucleic acid binding//zinc ion binding//metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.19959 BP_3 433.04 6.46 3521 642932408 XP_008197099.1 1304 1.4e-140 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1996 BP_3 66.60 1.07 3301 189237315 XP_972608.2 1722 4.5e-189 PREDICTED: protocadherin Fat 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14517 221 2.1e-16 Protocadherin Fat 1 OS=Homo sapiens GN=FAT1 PE=1 SV=2 PF00028//PF12199 Cadherin domain//Extracellular fibrinogen binding protein C terminal GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0001848//GO:0005509 complement binding//calcium ion binding GO:0005615//GO:0016020 extracellular space//membrane KOG3594 FOG: Cadherin repeats Cluster-8309.19961 BP_3 610.46 12.80 2591 642933047 XP_971594.2 2198 2.3e-244 PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum]>gi|642933049|ref|XP_008197242.1| PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum] -- -- -- -- -- K03372 ACATN, SLC33A1 MFS transporter, PAT family, solute carrier family 33 (acetyl-CoA transportor), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03372 Q6AYY8 1412 1.3e-154 Acetyl-coenzyme A transporter 1 OS=Rattus norvegicus GN=Slc33a1 PE=2 SV=1 PF01776//PF13000//PF07690 Ribosomal L22e protein family//Acetyl-coenzyme A transporter 1//Major Facilitator Superfamily GO:0042254//GO:0006412//GO:0015876//GO:0055085 ribosome biogenesis//translation//acetyl-CoA transport//transmembrane transport GO:0003735//GO:0008521 structural constituent of ribosome//acetyl-CoA transporter activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG3574 Acetyl-CoA transporter Cluster-8309.19962 BP_3 46.88 2.61 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19963 BP_3 70.97 2.74 1540 847164383 XP_012826122.1 993 7.2e-105 PREDICTED: uncharacterized protein LOC105948364 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0016788//GO:0003677 transposase activity//hydrolase activity, acting on ester bonds//DNA binding -- -- -- -- Cluster-8309.19964 BP_3 21.61 0.45 2612 642914050 XP_008201524.1 1506 4.0e-164 PREDICTED: sorting nexin-6 isoform X1 [Tribolium castaneum] 697469095 XM_009669926.1 81 1.10834e-31 PREDICTED: Struthio camelus australis sorting nexin 6 (SNX6), transcript variant X2, mRNA K17920 SNX5_6_32 sorting nexin-5/6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K17920 Q5R613 931 7.7e-99 Sorting nexin-6 OS=Pongo abelii GN=SNX6 PE=2 SV=1 PF04632//PF00787//PF01916 Fusaric acid resistance protein family//PX domain//Deoxyhypusine synthase GO:0008612//GO:0006810 peptidyl-lysine modification to peptidyl-hypusine//transport GO:0035091 phosphatidylinositol binding GO:0005886 plasma membrane KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.19965 BP_3 129.92 14.13 735 642939323 XP_969087.2 570 3.8e-56 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 295 1.2e-25 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01588 Putative tRNA binding domain -- -- GO:0000049 tRNA binding -- -- KOG2241 tRNA-binding protein Cluster-8309.19966 BP_3 7.00 4.06 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19967 BP_3 161.11 1.15 7068 642938595 XP_008199857.1 3648 0.0e+00 PREDICTED: C2 domain-containing protein 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86YS7 2135 5.1e-238 C2 domain-containing protein 5 OS=Homo sapiens GN=C2CD5 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1031 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.19969 BP_3 80.00 4.79 1097 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19970 BP_3 46.13 0.64 3764 662212463 XP_008479968.1 209 1.4e-13 PREDICTED: zinc finger protein 37-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 170 1.9e-10 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF02892//PF16622//PF13465//PF00096//PF00895 BED zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//ATP synthase protein 8 GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078//GO:0003677//GO:0046872 hydrogen ion transmembrane transporter activity//DNA binding//metal ion binding GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.19971 BP_3 504.00 24.91 1267 91089519 XP_970680.1 1043 9.4e-111 PREDICTED: deoxyhypusine hydroxylase [Tribolium castaneum]>gi|270012585|gb|EFA09033.1| hypothetical protein TcasGA2_TC006746 [Tribolium castaneum] 161661018 EU247113.1 38 4.24364e-08 Lycosa singoriensis deoxyhypusine hydroxylase-like mRNA, complete sequence K06072 DOHH deoxyhypusine monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K06072 Q9V9U4 937 7.6e-100 Deoxyhypusine hydroxylase OS=Drosophila melanogaster GN=nero PE=2 SV=1 PF00745//PF01347//PF02985 Glutamyl-tRNAGlu reductase, dimerisation domain//Lipoprotein amino terminal region//HEAT repeat GO:0055114//GO:0033014//GO:0006869 oxidation-reduction process//tetrapyrrole biosynthetic process//lipid transport GO:0050661//GO:0008883//GO:0005319//GO:0005515 NADP binding//glutamyl-tRNA reductase activity//lipid transporter activity//protein binding -- -- KOG0567 HEAT repeat-containing protein Cluster-8309.19973 BP_3 1.00 0.54 378 260835600 XP_002612796.1 185 8.7e-12 hypothetical protein BRAFLDRAFT_233081 [Branchiostoma floridae]>gi|229298176|gb|EEN68805.1| hypothetical protein BRAFLDRAFT_233081, partial [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UDV7 140 5.9e-08 Zinc finger protein 282 OS=Homo sapiens GN=ZNF282 PE=2 SV=3 PF01431//PF00096//PF13465 Peptidase family M13//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006508 proteolysis GO:0004222//GO:0046872 metalloendopeptidase activity//metal ion binding -- -- -- -- Cluster-8309.19976 BP_3 9.02 0.47 1215 260795190 XP_002592589.1 238 2.0e-17 hypothetical protein BRAFLDRAFT_118912 [Branchiostoma floridae]>gi|229277810|gb|EEN48600.1| hypothetical protein BRAFLDRAFT_118912 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XN6 167 1.4e-10 Zinc finger protein 761 OS=Homo sapiens GN=ZNF761 PE=2 SV=2 PF00569//PF13465//PF00096//PF01096 Zinc finger, ZZ type//Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS) GO:0006351 transcription, DNA-templated GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.19978 BP_3 7.45 0.40 1191 260810939 XP_002600180.1 200 5.0e-13 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 O75820 144 6.4e-08 Zinc finger protein 189 OS=Homo sapiens GN=ZNF189 PE=2 SV=2 PF01096//PF13465//PF00096 Transcription factor S-II (TFIIS)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006351 transcription, DNA-templated GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.19979 BP_3 7.32 0.41 1151 260810939 XP_002600180.1 202 2.8e-13 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZNG0 130 2.6e-06 Zinc finger protein 620 OS=Homo sapiens GN=ZNF620 PE=2 SV=1 PF13465//PF00096//PF01096 Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS) GO:0006351 transcription, DNA-templated GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.19981 BP_3 5.00 0.46 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19983 BP_3 3.51 0.63 559 642928426 XP_971688.3 278 2.1e-22 PREDICTED: RRP15-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VFE6 134 4.3e-07 RRP15-like protein OS=Drosophila melanogaster GN=CG3817 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19986 BP_3 143.00 2.21 3408 642921600 XP_969038.3 1586 2.7e-173 PREDICTED: probable ATP-dependent RNA helicase DDX28 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWT6 657 6.0e-67 Probable ATP-dependent RNA helicase DDX28 OS=Mus musculus GN=Ddx28 PE=2 SV=2 PF07178//PF01176//PF00270//PF00176//PF04851 TraL protein//Translation initiation factor 1A / IF-1//DEAD/DEAH box helicase//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0006413//GO:0000746//GO:0006446 translational initiation//conjugation//regulation of translational initiation GO:0003676//GO:0003723//GO:0005524//GO:0016787//GO:0003677//GO:0003743 nucleic acid binding//RNA binding//ATP binding//hydrolase activity//DNA binding//translation initiation factor activity GO:0005840//GO:0019867 ribosome//outer membrane -- -- Cluster-8309.19988 BP_3 47.00 1.43 1871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19989 BP_3 80.44 9.83 686 642929197 XP_008195731.1 1009 4.4e-107 PREDICTED: WD repeat-containing protein 7 isoform X1 [Tribolium castaneum]>gi|642929199|ref|XP_008195732.1| PREDICTED: WD repeat-containing protein 7 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y4E6 436 5.1e-42 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG4155 FOG: WD40 repeat Cluster-8309.1999 BP_3 94.76 2.54 2088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.19991 BP_3 1.16 0.43 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19993 BP_3 50.82 0.66 3980 546685810 ERL95253.1 780 9.3e-80 hypothetical protein D910_12520 [Dendroctonus ponderosae] -- -- -- -- -- K14410 ACP2 lysosomal acid phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14410 B1H1P9 513 3.5e-50 Lysosomal acid phosphatase OS=Xenopus laevis GN=acp2 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.19999 BP_3 53.12 0.35 7695 642934828 XP_008197827.1 4092 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 5.6e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.20000 BP_3 11.12 0.62 1160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02096 60Kd inner membrane protein GO:0051205 protein insertion into membrane -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20005 BP_3 104.13 3.59 1691 642935403 XP_008197996.1 881 7.6e-92 PREDICTED: tumor protein p63-regulated gene 1-like protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0D9 347 2.6e-31 Tumor protein p63-regulated gene 1-like protein OS=Homo sapiens GN=TPRG1L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20010 BP_3 2.00 0.42 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20012 BP_3 9.00 0.53 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20013 BP_3 7.00 0.31 1379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20015 BP_3 108.03 1.62 3502 768432767 XP_011557722.1 148 1.6e-06 PREDICTED: uncharacterized protein LOC105388496 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20016 BP_3 109.83 1.67 3461 768432767 XP_011557722.1 148 1.6e-06 PREDICTED: uncharacterized protein LOC105388496 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20017 BP_3 47.48 1.53 1783 91092400 XP_969218.1 763 3.9e-78 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 360 8.6e-33 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF00400//PF03875 WD domain, G-beta repeat//Statherin GO:0042742//GO:0030500 defense response to bacterium//regulation of bone mineralization GO:0046848//GO:0005515 hydroxyapatite binding//protein binding GO:0005576 extracellular region KOG2919 Guanine nucleotide-binding protein Cluster-8309.20019 BP_3 39.44 0.37 5391 642935536 XP_008198049.1 1893 1.1e-208 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X3 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q14642 962 4.1e-102 Type I inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens GN=INPP5A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1976 Inositol polyphosphate 5-phosphatase, type I Cluster-8309.20020 BP_3 27.77 0.33 4396 478259502 ENN79383.1 5149 0.0e+00 hypothetical protein YQE_04170, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- H9JIQ1 3946 0.0e+00 Protein mesh OS=Bombyx mori PE=1 SV=1 PF06119//PF00779//PF01833 Nidogen-like//BTK motif//IPT/TIG domain GO:0007160//GO:0035556 cell-matrix adhesion//intracellular signal transduction GO:0005515 protein binding -- -- KOG4291 Mucin/alpha-tectorin Cluster-8309.20023 BP_3 17.32 0.31 3001 91085407 XP_967344.1 824 5.5e-85 PREDICTED: peroxisome assembly protein 12 [Tribolium castaneum] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 A4FUD4 305 3.4e-26 Peroxisome assembly protein 12 OS=Bos taurus GN=PEX12 PE=2 SV=1 PF07685 CobB/CobQ-like glutamine amidotransferase domain GO:0009236 cobalamin biosynthetic process GO:0003824 catalytic activity -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.20024 BP_3 17.58 0.39 2490 91085407 XP_967344.1 1098 7.7e-117 PREDICTED: peroxisome assembly protein 12 [Tribolium castaneum] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 1.8e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF13639//PF07685//PF00097//PF12678 Ring finger domain//CobB/CobQ-like glutamine amidotransferase domain//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger GO:0009236 cobalamin biosynthetic process GO:0046872//GO:0005515//GO:0008270//GO:0003824 metal ion binding//protein binding//zinc ion binding//catalytic activity -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.20025 BP_3 55.00 6.66 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04189 Gcd10p family GO:0030488 tRNA methylation -- -- GO:0031515 tRNA (m1A) methyltransferase complex -- -- Cluster-8309.20026 BP_3 79.31 5.19 1028 478250011 ENN70517.1 600 1.8e-59 hypothetical protein YQE_12693, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VTI8 255 7.4e-21 Protein charybde OS=Drosophila melanogaster GN=chrb PE=2 SV=2 PF07809//PF01318 RTP801 C-terminal region//Bromovirus coat protein GO:0009968 negative regulation of signal transduction GO:0005198 structural molecule activity GO:0019028//GO:0005737 viral capsid//cytoplasm -- -- Cluster-8309.20029 BP_3 13.00 3.53 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20030 BP_3 87.99 1.30 3561 270000870 EEZ97317.1 1789 8.3e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.50049e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.6e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.20034 BP_3 15.00 1.48 779 -- -- -- -- -- 755883692 XM_011295486.1 41 5.51733e-10 PREDICTED: Musca domestica cytoplasmic dynein 1 intermediate chain (LOC101888373), transcript variant X15, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20035 BP_3 6.00 1.44 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20036 BP_3 49.74 2.27 1346 270003908 EFA00356.1 1025 1.2e-108 hypothetical protein TcasGA2_TC003198 [Tribolium castaneum] -- -- -- -- -- K19573 ATAT1, MEC17 alpha-tubulin N-acetyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19573 Q16Y34 630 3.2e-64 Alpha-tubulin N-acetyltransferase OS=Aedes aegypti GN=AAEL008679 PE=3 SV=1 PF03494//PF00583//PF13508//PF05301//PF13673 Beta-amyloid peptide (beta-APP)//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Acetyltransferase (GNAT) domain GO:0042967//GO:0071929 acyl-carrier-protein biosynthetic process//alpha-tubulin acetylation GO:0019799//GO:0008080 tubulin N-acetyltransferase activity//N-acetyltransferase activity GO:0016021//GO:0005874//GO:0045298 integral component of membrane//microtubule//tubulin complex KOG4601 Uncharacterized conserved protein Cluster-8309.20041 BP_3 108.00 29.31 469 91079766 XP_966799.1 270 1.5e-21 PREDICTED: protein claret segregational [Tribolium castaneum]>gi|270003319|gb|EEZ99766.1| hypothetical protein TcasGA2_TC002539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BPU3 160 3.5e-10 Kinesin-related protein 2 OS=Dictyostelium discoideum GN=kif2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0239 Kinesin (KAR3 subfamily) Cluster-8309.20042 BP_3 47.52 0.92 2768 642928421 XP_008193780.1 3184 0.0e+00 PREDICTED: probable cleavage and polyadenylation specificity factor subunit 2 [Tribolium castaneum]>gi|270010824|gb|EFA07272.1| hypothetical protein TcasGA2_TC014506 [Tribolium castaneum] 665813545 XM_008557111.1 256 6.13677e-129 PREDICTED: Microplitis demolitor probable cleavage and polyadenylation specificity factor subunit 2 (LOC103576746), mRNA K14402 CPSF2, CFT2 cleavage and polyadenylation specificity factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14402 Q9V3D6 2508 1.1e-281 Probable cleavage and polyadenylation specificity factor subunit 2 OS=Drosophila melanogaster GN=Cpsf100 PE=1 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit) Cluster-8309.20043 BP_3 59.54 2.24 1572 548544410 XP_005753889.1 472 1.9e-44 PREDICTED: zinc finger protein 84-like [Pundamilia nyererei] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 434 2.0e-41 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13465//PF00096//PF07776//PF13912//PF02892//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat -- -- Cluster-8309.20045 BP_3 157.79 2.31 3586 861617776 KMQ86664.1 685 8.7e-69 transposase [Lasius niger] 795025225 XM_012006147.1 47 1.2138e-12 PREDICTED: Vollenhovia emeryi uncharacterized LOC105558450 (LOC105558450), mRNA K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q8I7P9 304 5.4e-26 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF01498//PF01529//PF08281//PF12844//PF00665//PF04545//PF13683//PF13443 Transposase//DHHC palmitoyltransferase//Sigma-70, region 4//Helix-turn-helix domain//Integrase core domain//Sigma-70, region 4//Integrase core domain//Cro/C1-type HTH DNA-binding domain GO:0006313//GO:0006355//GO:0006352//GO:0015074 transposition, DNA-mediated//regulation of transcription, DNA-templated//DNA-templated transcription, initiation//DNA integration GO:0003677//GO:0008270//GO:0043565//GO:0016987//GO:0003700 DNA binding//zinc ion binding//sequence-specific DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.20048 BP_3 129.08 1.04 6283 827552693 XP_012548103.1 1104 3.9e-117 PREDICTED: uncharacterized protein LOC105842033 [Bombyx mori] -- -- -- -- -- -- -- -- -- Q8N328 396 2.0e-36 PiggyBac transposable element-derived protein 3 OS=Homo sapiens GN=PGBD3 PE=2 SV=3 PF05225//PF03184//PF01061//PF14822//PF01245 helix-turn-helix, Psq domain//DDE superfamily endonuclease//ABC-2 type transporter//Vasohibin//Ribosomal protein L19 GO:0042254//GO:0045765//GO:0006412 ribosome biogenesis//regulation of angiogenesis//translation GO:0003676//GO:0003735//GO:0003677 nucleic acid binding//structural constituent of ribosome//DNA binding GO:0005737//GO:0016020//GO:0005622//GO:0005840 cytoplasm//membrane//intracellular//ribosome -- -- Cluster-8309.20049 BP_3 2.00 0.71 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20053 BP_3 7.00 0.49 983 91082325 XP_974590.1 318 8.5e-27 PREDICTED: epididymal secretory protein E1 [Tribolium castaneum]>gi|270008209|gb|EFA04657.1| hypothetical protein TcasGA2_TC014069 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20054 BP_3 337.00 31.65 805 332377007 AEE63643.1 551 6.7e-54 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 259 2.0e-21 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0006446//GO:0007423//GO:0006413 regulation of translational initiation//sensory organ development//translational initiation GO:0005212//GO:0003743 structural constituent of eye lens//translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.20055 BP_3 27.00 4.01 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20056 BP_3 75.71 1.56 2637 91083325 XP_974870.1 1811 1.7e-199 PREDICTED: E3 ubiquitin-protein ligase MIB1 [Tribolium castaneum] 657810720 XM_008334462.1 101 8.52958e-43 PREDICTED: Cynoglossus semilaevis mindbomb E3 ubiquitin protein ligase 1 (mib1), transcript variant X2, mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q86YT6 1415 5.9e-155 E3 ubiquitin-protein ligase MIB1 OS=Homo sapiens GN=MIB1 PE=1 SV=1 PF00023//PF00097//PF13606//PF14634//PF13639 Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//zinc-RING finger domain//Ring finger domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.20058 BP_3 438.79 16.53 1571 642912679 XP_969682.2 1119 1.8e-119 PREDICTED: geranylgeranyl transferase type-1 subunit beta [Tribolium castaneum] -- -- -- -- -- K11713 PGTB1 geranylgeranyl transferase type-1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K11713 Q5EAD5 703 1.3e-72 Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus GN=PGGT1B PE=2 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat -- -- GO:0003824 catalytic activity -- -- KOG0367 Protein geranylgeranyltransferase Type I, beta subunit Cluster-8309.20059 BP_3 14.55 0.46 1816 478252231 ENN72659.1 1051 1.6e-111 hypothetical protein YQE_10757, partial [Dendroctonus ponderosae]>gi|546675747|gb|ERL86879.1| hypothetical protein D910_04282 [Dendroctonus ponderosae] -- -- -- -- -- K11713 PGTB1 geranylgeranyl transferase type-1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K11713 Q5EAD5 680 6.8e-70 Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus GN=PGGT1B PE=2 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat -- -- GO:0003824 catalytic activity -- -- KOG0367 Protein geranylgeranyltransferase Type I, beta subunit Cluster-8309.2006 BP_3 36.65 1.05 1971 546672571 ERL84381.1 452 5.0e-42 hypothetical protein D910_01811, partial [Dendroctonus ponderosae] -- -- -- -- -- K19398 BBS9 Bardet-Biedl syndrome 9 protein http://www.genome.jp/dbget-bin/www_bget?ko:K19398 Q6AX60 229 1.5e-17 Protein PTHB1 OS=Xenopus laevis GN=bbs9 PE=2 SV=1 PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.20060 BP_3 89.25 3.22 1626 642912679 XP_969682.2 1119 1.9e-119 PREDICTED: geranylgeranyl transferase type-1 subunit beta [Tribolium castaneum] -- -- -- -- -- K11713 PGTB1 geranylgeranyl transferase type-1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K11713 Q5EAD5 703 1.3e-72 Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus GN=PGGT1B PE=2 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat -- -- GO:0003824 catalytic activity -- -- KOG0367 Protein geranylgeranyltransferase Type I, beta subunit Cluster-8309.20062 BP_3 5.00 0.50 774 478252126 ENN72557.1 389 3.9e-35 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19096 128 3.0e-06 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.2007 BP_3 480.72 10.26 2549 642911634 XP_968416.2 2471 4.9e-276 PREDICTED: serine proteinase stubble [Tribolium castaneum] 815914183 XM_012386953.1 264 2.01737e-133 PREDICTED: Bombus impatiens serine proteinase stubble (LOC100748461), mRNA -- -- -- -- P03952 424 4.7e-40 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20072 BP_3 16.53 0.41 2219 291170320 ADD82416.1 191 1.0e-11 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170321 GU584934.1 111 1.97653e-48 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20075 BP_3 140.29 2.73 2771 270003816 EFA00264.1 166 1.0e-08 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225 helix-turn-helix, Psq domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.20077 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20078 BP_3 65.57 1.31 2708 642921567 XP_008192427.1 2882 0.0e+00 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1457 8.1e-160 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF13374//PF00515//PF02891//PF03854//PF06464//PF13176//PF00637//PF13181 Tetratricopeptide repeat//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//P-11 zinc finger//DMAP1-binding Domain//Tetratricopeptide repeat//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0005515//GO:0008134//GO:0003723 zinc ion binding//protein binding//transcription factor binding//RNA binding GO:0005622//GO:0005667//GO:0005634 intracellular//transcription factor complex//nucleus KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.20079 BP_3 615.00 13.37 2508 91087967 XP_973079.1 1853 2.2e-204 PREDICTED: U3 small nucleolar RNA-associated protein 14 homolog A [Tribolium castaneum]>gi|270012047|gb|EFA08495.1| hypothetical protein TcasGA2_TC006147 [Tribolium castaneum] -- -- -- -- -- K14567 UTP14 U3 small nucleolar RNA-associated protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K14567 Q9BVJ6 522 2.0e-51 U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens GN=UTP14A PE=1 SV=1 PF04615 Utp14 protein GO:0006364 rRNA processing -- -- GO:0032040 small-subunit processome KOG2172 Uncharacterized conserved protein Cluster-8309.2008 BP_3 34.63 0.69 2726 642911634 XP_968416.2 2184 1.0e-242 PREDICTED: serine proteinase stubble [Tribolium castaneum] 815914183 XM_012386953.1 264 2.15792e-133 PREDICTED: Bombus impatiens serine proteinase stubble (LOC100748461), mRNA -- -- -- -- P03952 424 5.0e-40 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20081 BP_3 1.00 3.39 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02202 Tachykinin family GO:0007217//GO:0007268 tachykinin receptor signaling pathway//synaptic transmission -- -- -- -- -- -- Cluster-8309.20083 BP_3 33.33 2.41 957 270004868 EFA01316.1 280 2.1e-22 hypothetical protein TcasGA2_TC003278 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55918 226 1.6e-17 Microfibril-associated glycoprotein 4 OS=Bos taurus GN=MFAP4 PE=1 SV=2 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.20085 BP_3 14.11 0.35 2245 189237609 XP_968824.2 1064 6.1e-113 PREDICTED: sodium/potassium/calcium exchanger 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13751 SLC24A3, NCKX3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13751 Q9HC58 492 5.3e-48 Sodium/potassium/calcium exchanger 3 OS=Homo sapiens GN=SLC24A3 PE=2 SV=4 PF01699//PF16367 Sodium/calcium exchanger protein//RNA recognition motif GO:0055085 transmembrane transport GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.20086 BP_3 64.00 2.20 1694 270005908 EFA02356.1 1594 1.6e-174 hypothetical protein TcasGA2_TC008028 [Tribolium castaneum] -- -- -- -- -- K00453 E1.13.11.11, TDO2 tryptophan 2,3-dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00453 Q95NN1 1592 1.1e-175 Tryptophan 2,3-dioxygenase OS=Tribolium castaneum PE=2 SV=1 PF03301//PF10391 Tryptophan 2,3-dioxygenase//Fingers domain of DNA polymerase lambda GO:0006568//GO:0019441 tryptophan metabolic process//tryptophan catabolic process to kynurenine GO:0034061//GO:0020037//GO:0004833//GO:0003677 DNA polymerase activity//heme binding//tryptophan 2,3-dioxygenase activity//DNA binding GO:0005634 nucleus KOG3906 Tryptophan 2,3-dioxygenase Cluster-8309.20088 BP_3 17.81 0.42 2328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2009 BP_3 20.34 0.42 2633 817218976 XP_012285276.1 2121 1.9e-235 PREDICTED: serine proteinase stubble isoform X2 [Orussus abietinus] 815914183 XM_012386953.1 264 2.08477e-133 PREDICTED: Bombus impatiens serine proteinase stubble (LOC100748461), mRNA -- -- -- -- P03952 424 4.8e-40 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20090 BP_3 680.00 11.03 3263 270008711 EFA05159.1 262 8.8e-20 hypothetical protein TcasGA2_TC015278 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02660//PF00847//PF02949 Glycerol-3-phosphate acyltransferase//AP2 domain//7tm Odorant receptor GO:0008654//GO:0007608//GO:0006355//GO:0007187 phospholipid biosynthetic process//sensory perception of smell//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0003700//GO:0004984//GO:0043772//GO:0005549 transcription factor activity, sequence-specific DNA binding//olfactory receptor activity//acyl-phosphate glycerol-3-phosphate acyltransferase activity//odorant binding GO:0016020//GO:0005667//GO:0005886 membrane//transcription factor complex//plasma membrane -- -- Cluster-8309.20095 BP_3 16.00 3.91 489 270013391 EFA09839.1 835 4.8e-87 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82279 147 1.2e-08 Protein crumbs homolog 1 OS=Homo sapiens GN=CRB1 PE=1 SV=2 PF01073//PF00008 3-beta hydroxysteroid dehydrogenase/isomerase family//EGF-like domain GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//estrogen metabolic process GO:0003854//GO:0016616//GO:0005515 3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.20096 BP_3 36.00 5.38 614 270013391 EFA09839.1 863 3.4e-90 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 144 3.3e-08 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.2010 BP_3 14.00 3.70 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20100 BP_3 23.53 0.53 2429 642928571 XP_008199962.1 539 5.0e-52 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q16MW6 512 2.8e-50 S-methyl-5'-thioadenosine phosphorylase OS=Aedes aegypti GN=AAEL012172 PE=3 SV=1 PF01048//PF09242 Phosphorylase superfamily//Flavocytochrome c sulphide dehydrogenase, flavin-binding GO:0055114//GO:0009116 oxidation-reduction process//nucleoside metabolic process GO:0016491//GO:0003824//GO:0050660 oxidoreductase activity//catalytic activity//flavin adenine dinucleotide binding -- -- KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.20103 BP_3 8.60 0.35 1493 91093365 XP_969666.1 1912 1.9e-211 PREDICTED: nedd8-activating enzyme E1 catalytic subunit [Tribolium castaneum]>gi|270015296|gb|EFA11744.1| hypothetical protein TcasGA2_TC004234 [Tribolium castaneum] -- -- -- -- -- K10686 UBE1C, UBA3 ubiquitin-activating enzyme E1 C http://www.genome.jp/dbget-bin/www_bget?ko:K10686 Q7ZVX6 1579 3.2e-174 NEDD8-activating enzyme E1 catalytic subunit OS=Danio rerio GN=uba3 PE=2 SV=1 PF00070//PF00899//PF08825 Pyridine nucleotide-disulphide oxidoreductase//ThiF family//E2 binding domain GO:0045116//GO:0055114 protein neddylation//oxidation-reduction process GO:0016881//GO:0005524//GO:0016491//GO:0008641 acid-amino acid ligase activity//ATP binding//oxidoreductase activity//small protein activating enzyme activity -- -- KOG2015 NEDD8-activating complex, catalytic component UBA3 Cluster-8309.20104 BP_3 27.73 0.50 2956 546679741 ERL90152.1 1446 4.1e-157 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BKN5 453 2.3e-43 Gamma-tubulin complex component 5 OS=Mus musculus GN=Tubgcp5 PE=2 SV=2 PF04130//PF04505 Spc97 / Spc98 family//Interferon-induced transmembrane protein GO:0090063//GO:0000226//GO:0009607 positive regulation of microtubule nucleation//microtubule cytoskeleton organization//response to biotic stimulus -- -- GO:0016021//GO:0005815//GO:0000922 integral component of membrane//microtubule organizing center//spindle pole -- -- Cluster-8309.20107 BP_3 2.00 0.35 566 227018324 ACP18828.1 419 9.5e-39 chitin deacetylase 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01522 Polysaccharide deacetylase GO:0005975//GO:0006807 carbohydrate metabolic process//nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.20111 BP_3 10.41 0.36 1702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20116 BP_3 42.55 0.34 6320 642929348 XP_008195797.1 4119 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1650 7.9e-182 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF00225//PF00787//PF00498//PF09111 Kinesin motor domain//PX domain//FHA domain//SLIDE GO:0007018//GO:0006338//GO:0007017 microtubule-based movement//chromatin remodeling//microtubule-based process GO:0005524//GO:0035091//GO:0005515//GO:0003777//GO:0003676//GO:0008017//GO:0016818 ATP binding//phosphatidylinositol binding//protein binding//microtubule motor activity//nucleic acid binding//microtubule binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634//GO:0045298//GO:0005874 nucleus//tubulin complex//microtubule KOG0245 Kinesin-like protein Cluster-8309.20117 BP_3 114.27 0.92 6265 642929348 XP_008195797.1 3590 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1650 7.9e-182 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF08352//PF09111//PF00787//PF00498//PF00225 Oligopeptide/dipeptide transporter, C-terminal region//SLIDE//PX domain//FHA domain//Kinesin motor domain GO:0015833//GO:0007017//GO:0007018//GO:0006338 peptide transport//microtubule-based process//microtubule-based movement//chromatin remodeling GO:0003676//GO:0008017//GO:0000166//GO:0016818//GO:0005524//GO:0005515//GO:0035091//GO:0003777 nucleic acid binding//microtubule binding//nucleotide binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//protein binding//phosphatidylinositol binding//microtubule motor activity GO:0005634//GO:0045298//GO:0005874 nucleus//tubulin complex//microtubule KOG0245 Kinesin-like protein Cluster-8309.20120 BP_3 50.49 0.74 3591 91090862 XP_972769.1 1041 4.5e-110 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 98 5.42019e-41 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 Q6PC30 885 2.3e-93 COP9 signalosome complex subunit 5 OS=Danio rerio GN=cops5 PE=2 SV=1 PF01040//PF03083//PF01398 UbiA prenyltransferase family//Sugar efflux transporter for intercellular exchange//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0004659//GO:0005515 prenyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.20121 BP_3 135.85 1.69 4159 478263614 ENN81920.1 2036 2.2e-225 hypothetical protein YQE_01631, partial [Dendroctonus ponderosae] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 725 9.5e-75 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.20123 BP_3 140.89 1.83 4004 546679674 ERL90101.1 1875 9.9e-207 hypothetical protein D910_07455 [Dendroctonus ponderosae] 642934912 XM_008199638.1 468 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X3, mRNA K04496 CTBP C-terminal binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04496 O46036 1708 9.5e-189 C-terminal-binding protein OS=Drosophila melanogaster GN=CtBP PE=1 SV=3 PF03493//PF00389//PF02826//PF03446//PF16622 Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//zinc-finger C2H2-type GO:0006098//GO:0008152//GO:0006813//GO:0019521//GO:0055114 pentose-phosphate shunt//metabolic process//potassium ion transport//D-gluconate metabolic process//oxidation-reduction process GO:0016616//GO:0051287//GO:0015269//GO:0004616//GO:0046872 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//calcium-activated potassium channel activity//phosphogluconate dehydrogenase (decarboxylating) activity//metal ion binding GO:0016020 membrane KOG0067 Transcription factor CtBP Cluster-8309.20127 BP_3 151.00 36.30 492 642925502 XP_008194577.1 360 5.7e-32 PREDICTED: immediate early response 3-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3B8G7 240 1.9e-19 Immediate early response 3-interacting protein 1 OS=Xenopus laevis GN=ier3ip1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4779 Predicted membrane protein Cluster-8309.20129 BP_3 28.84 0.75 2155 642919337 XP_008191830.1 622 1.1e-61 PREDICTED: protein atonal homolog 7-like [Tribolium castaneum]>gi|270005529|gb|EFA01977.1| hypothetical protein TcasGA2_TC007598 [Tribolium castaneum] -- -- -- -- -- K09104 K09104 bHLH factor, other http://www.genome.jp/dbget-bin/www_bget?ko:K09104 P41894 264 1.4e-21 Helix-loop-helix protein delilah OS=Drosophila melanogaster GN=tx PE=1 SV=3 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3898 Transcription factor NeuroD and related HTH proteins Cluster-8309.2013 BP_3 3.00 3.61 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20130 BP_3 1.00 3.12 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20131 BP_3 30.16 0.79 2124 642919337 XP_008191830.1 674 9.7e-68 PREDICTED: protein atonal homolog 7-like [Tribolium castaneum]>gi|270005529|gb|EFA01977.1| hypothetical protein TcasGA2_TC007598 [Tribolium castaneum] -- -- -- -- -- K09104 K09104 bHLH factor, other http://www.genome.jp/dbget-bin/www_bget?ko:K09104 P41894 264 1.4e-21 Helix-loop-helix protein delilah OS=Drosophila melanogaster GN=tx PE=1 SV=3 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3898 Transcription factor NeuroD and related HTH proteins Cluster-8309.20135 BP_3 34.33 2.34 998 332373466 AEE61874.1 569 6.8e-56 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03539 RPP1, RPP30 ribonuclease P/MRP protein subunit RPP1 http://www.genome.jp/dbget-bin/www_bget?ko:K03539 P78346 231 4.4e-18 Ribonuclease P protein subunit p30 OS=Homo sapiens GN=RPP30 PE=1 SV=1 PF01876 RNase P subunit p30 GO:0008033//GO:0051252 tRNA processing//regulation of RNA metabolic process GO:0004540 ribonuclease activity -- -- KOG2363 Protein subunit of nuclear ribonuclease P (RNase P) Cluster-8309.20139 BP_3 154.79 4.05 2133 642915726 XP_008190777.1 1386 2.7e-150 PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum]>gi|642915728|ref|XP_008190778.1| PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 Q9NWF9 442 3.2e-42 E3 ubiquitin-protein ligase RNF216 OS=Homo sapiens GN=RNF216 PE=1 SV=3 PF03119//PF02807//PF10044 NAD-dependent DNA ligase C4 zinc finger domain//ATP:guanido phosphotransferase, N-terminal domain//Retinal tissue protein GO:0006281//GO:0006351//GO:0007049//GO:0006260 DNA repair//transcription, DNA-templated//cell cycle//DNA replication GO:0003911//GO:0016772//GO:0016301 DNA ligase (NAD+) activity//transferase activity, transferring phosphorus-containing groups//kinase activity GO:0070176 DRM complex -- -- Cluster-8309.20140 BP_3 65.00 21.19 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20144 BP_3 9.03 0.63 979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20145 BP_3 2.00 0.67 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20146 BP_3 105.95 12.48 701 53830039 AAU94927.1 408 2.2e-37 larval cuticle protein 8.7 [Apriona germari] 53830038 AY769984.1 294 1.12661e-150 Apriona germari larval cuticle protein 8.7 mRNA, complete cds -- -- -- -- Q7M4E8 229 5.2e-18 Endocuticle structural protein SgAbd-6 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.20149 BP_3 87.22 1.04 4326 642911033 XP_008193517.1 2777 3.4e-311 PREDICTED: small conductance calcium-activated potassium channel protein [Tribolium castaneum] 642911032 XM_008195295.1 710 0 PREDICTED: Tribolium castaneum small conductance calcium-activated potassium channel protein (LOC657962), mRNA K05325 KCNNN potassium intermediate/small conductance calcium-activated channel subfamily N, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05325 Q7KVW5 2299 3.0e-257 Small conductance calcium-activated potassium channel protein OS=Drosophila melanogaster GN=SK PE=2 SV=2 PF03530//PF01407//PF01544//PF03119//PF02888//PF00520 Calcium-activated SK potassium channel//Geminivirus AL3 protein//CorA-like Mg2+ transporter protein//NAD-dependent DNA ligase C4 zinc finger domain//Calmodulin binding domain//Ion transport protein GO:0006813//GO:0006281//GO:0030001//GO:0055085//GO:0016032//GO:0006811//GO:0006260 potassium ion transport//DNA repair//metal ion transport//transmembrane transport//viral process//ion transport//DNA replication GO:0016286//GO:0015269//GO:0005516//GO:0003911//GO:0005216//GO:0046873 small conductance calcium-activated potassium channel activity//calcium-activated potassium channel activity//calmodulin binding//DNA ligase (NAD+) activity//ion channel activity//metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3684 Ca2+-activated K+ channel proteins (intermediate/small conductance classes) Cluster-8309.20153 BP_3 183.23 13.22 960 642933131 XP_008197270.1 918 2.2e-96 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] 462326012 APGK01041603.1 84 8.5628e-34 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- Q8N4B1 379 2.9e-35 Sesquipedalian-1 OS=Homo sapiens GN=FAM109A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20155 BP_3 5.59 0.54 788 642932969 XP_008197210.1 358 1.6e-31 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20162 BP_3 13.00 1.90 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20165 BP_3 47.56 1.41 1920 642915433 XP_008190613.1 571 7.7e-56 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13508//PF13302//PF13673//PF08445 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.20166 BP_3 155.69 6.37 1470 642930675 XP_966843.2 1163 1.3e-124 PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 P08111 601 8.0e-61 Lethal(2) giant larvae protein OS=Drosophila melanogaster GN=l(2)gl PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.20167 BP_3 17.25 0.36 2633 642930675 XP_966843.2 1130 1.6e-120 PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 P08111 580 3.9e-58 Lethal(2) giant larvae protein OS=Drosophila melanogaster GN=l(2)gl PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.20168 BP_3 173.68 10.12 1119 642915266 XP_971845.3 865 3.6e-90 PREDICTED: sorting nexin-16 [Tribolium castaneum]>gi|270003912|gb|EFA00360.1| hypothetical protein TcasGA2_TC003202 [Tribolium castaneum] -- -- -- -- -- K17928 SNX16 sorting nexin-16 http://www.genome.jp/dbget-bin/www_bget?ko:K17928 P57768 338 1.9e-30 Sorting nexin-16 OS=Homo sapiens GN=SNX16 PE=1 SV=2 PF08702//PF00787 Fibrinogen alpha/beta chain family//PX domain GO:0051258//GO:0030168//GO:0007165 protein polymerization//platelet activation//signal transduction GO:0035091//GO:0005102//GO:0030674 phosphatidylinositol binding//receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-8309.20170 BP_3 66.91 1.29 2799 642921104 XP_008192691.1 1190 1.9e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.8e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF15678 Centriole duplication and mitotic chromosome congression GO:0090307 mitotic spindle assembly -- -- -- -- KOG2548 SWAP mRNA splicing regulator Cluster-8309.20171 BP_3 4.00 0.62 604 893567414 NP_001297599.1 234 2.9e-17 zinc finger protein 111 isoform 2 [Mus musculus]>gi|5640013|gb|AAD45927.1|AF167318_1 zinc finger protein ZFP111 [Mus musculus]>gi|148692404|gb|EDL24351.1| mCG22852 [Mus musculus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NK53 213 3.2e-16 Zinc finger protein 233 OS=Homo sapiens GN=ZNF233 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20172 BP_3 47.75 0.52 4705 676426419 XP_009044617.1 831 1.3e-85 hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea]>gi|556116066|gb|ESP04718.1| hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 765 2.5e-79 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00096//PF06397//PF00130//PF01842//PF04810//PF13912//PF16622//PF13465 Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//ACT domain//Sec23/Sec24 zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain GO:0006888//GO:0006886//GO:0008152//GO:0035556 ER to Golgi vesicle-mediated transport//intracellular protein transport//metabolic process//intracellular signal transduction GO:0005506//GO:0046872//GO:0008270//GO:0016597 iron ion binding//metal ion binding//zinc ion binding//amino acid binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.20174 BP_3 10.71 0.31 1976 642914050 XP_008201524.1 1511 7.9e-165 PREDICTED: sorting nexin-6 isoform X1 [Tribolium castaneum] 697469095 XM_009669926.1 81 8.34804e-32 PREDICTED: Struthio camelus australis sorting nexin 6 (SNX6), transcript variant X2, mRNA K17920 SNX5_6_32 sorting nexin-5/6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K17920 Q5R613 931 5.8e-99 Sorting nexin-6 OS=Pongo abelii GN=SNX6 PE=2 SV=1 PF01916//PF04632//PF00787 Deoxyhypusine synthase//Fusaric acid resistance protein family//PX domain GO:0006810//GO:0008612 transport//peptidyl-lysine modification to peptidyl-hypusine GO:0035091 phosphatidylinositol binding GO:0005886 plasma membrane KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.20175 BP_3 236.00 3.60 3452 646705167 KDR13034.1 1480 5.4e-161 Myotubularin-related protein 14 [Zootermopsis nevadensis] -- -- -- -- -- K18086 MTMR14 myotubularin-related protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K18086 Q8NCE2 1050 1.6e-112 Myotubularin-related protein 14 OS=Homo sapiens GN=MTMR14 PE=1 SV=2 PF09788//PF00102 Transmembrane protein 55A//Protein-tyrosine phosphatase GO:0046856//GO:0006470//GO:0006570 phosphatidylinositol dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0034597//GO:0004725 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.20177 BP_3 39.15 0.57 3581 642933420 XP_008197410.1 807 6.2e-83 PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N957 230 2.0e-17 Ankyrin repeat and fibronectin type-III domain-containing protein 1 OS=Homo sapiens GN=ANKFN1 PE=2 SV=2 PF00041//PF00023//PF12678//PF13606 Fibronectin type III domain//Ankyrin repeat//RING-H2 zinc finger//Ankyrin repeat -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.20179 BP_3 28.29 0.53 2868 91091470 XP_973218.1 335 2.7e-28 PREDICTED: peroxisomal membrane protein 11C [Tribolium castaneum]>gi|270000949|gb|EEZ97396.1| hypothetical protein TcasGA2_TC011223 [Tribolium castaneum] -- -- -- -- -- K13353 PEX11C peroxin-11C http://www.genome.jp/dbget-bin/www_bget?ko:K13353 Q96HA9 139 5.8e-07 Peroxisomal membrane protein 11C OS=Homo sapiens GN=PEX11G PE=1 SV=1 PF05648 Peroxisomal biogenesis factor 11 (PEX11) GO:0016559 peroxisome fission -- -- GO:0005779 integral component of peroxisomal membrane -- -- Cluster-8309.20181 BP_3 44.00 2.85 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20185 BP_3 47.26 0.69 3603 641649257 XP_008185321.1 466 2.2e-43 PREDICTED: uncharacterized protein LOC103310050 [Acyrthosiphon pisum] -- -- -- -- -- K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8CGZ0 259 8.9e-21 Calcium homeostasis endoplasmic reticulum protein OS=Mus musculus GN=Cherp PE=1 SV=1 PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- KOG4368 Predicted RNA binding protein, contains SWAP, RPR and G-patch domains Cluster-8309.20189 BP_3 301.14 7.56 2211 270014457 EFA10905.1 278 8.3e-22 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776 Zinc knuckle//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.2019 BP_3 21.00 1.25 1099 642936483 XP_968389.2 639 5.7e-64 PREDICTED: probable DNA replication complex GINS protein PSF2 [Tribolium castaneum] -- -- -- -- -- K10733 GINS2, PSF2 GINS complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10733 Q9VQY9 542 4.2e-54 Probable DNA replication complex GINS protein PSF2 OS=Drosophila melanogaster GN=Psf2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4071 Uncharacterized conserved protein Cluster-8309.20190 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20191 BP_3 65.99 3.38 1232 91076488 XP_972738.1 1234 6.5e-133 PREDICTED: activator of 90 kDa heat shock protein ATPase homolog 1 [Tribolium castaneum]>gi|642912536|ref|XP_008200903.1| PREDICTED: activator of 90 kDa heat shock protein ATPase homolog 1 [Tribolium castaneum]>gi|270002597|gb|EEZ99044.1| hypothetical protein TcasGA2_TC004918 [Tribolium castaneum] 572315610 XM_006623391.1 101 3.92387e-43 PREDICTED: Apis dorsata activator of 90 kDa heat shock protein ATPase homolog 1-like (LOC102679971), mRNA -- -- -- -- Q8BK64 719 1.4e-74 Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=2 SV=2 PF08327//PF09229 Activator of Hsp90 ATPase homolog 1-like protein//Activator of Hsp90 ATPase, N-terminal GO:0032781//GO:0006950 positive regulation of ATPase activity//response to stress GO:0001671//GO:0051087 ATPase activator activity//chaperone binding -- -- KOG2936 Uncharacterized conserved protein Cluster-8309.20192 BP_3 323.01 11.85 1606 91076488 XP_972738.1 1383 4.5e-150 PREDICTED: activator of 90 kDa heat shock protein ATPase homolog 1 [Tribolium castaneum]>gi|642912536|ref|XP_008200903.1| PREDICTED: activator of 90 kDa heat shock protein ATPase homolog 1 [Tribolium castaneum]>gi|270002597|gb|EEZ99044.1| hypothetical protein TcasGA2_TC004918 [Tribolium castaneum] 572315610 XM_006623391.1 101 5.14987e-43 PREDICTED: Apis dorsata activator of 90 kDa heat shock protein ATPase homolog 1-like (LOC102679971), mRNA -- -- -- -- Q8BK64 812 3.0e-85 Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=2 SV=2 PF08327//PF09229 Activator of Hsp90 ATPase homolog 1-like protein//Activator of Hsp90 ATPase, N-terminal GO:0006950//GO:0032781 response to stress//positive regulation of ATPase activity GO:0051087//GO:0001671 chaperone binding//ATPase activator activity -- -- KOG2936 Uncharacterized conserved protein Cluster-8309.20193 BP_3 55.23 0.67 4249 642922112 XP_008193020.1 613 2.3e-60 PREDICTED: calcium channel flower isoform X2 [Tribolium castaneum]>gi|270007428|gb|EFA03876.1| hypothetical protein TcasGA2_TC014000 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MXW6 324 3.1e-28 Calcium channel flower OS=Drosophila willistoni GN=flower PE=3 SV=2 PF03613//PF10233 PTS system mannose/fructose/sorbose family IID component//Uncharacterized conserved protein CG6151-P GO:0048488//GO:0070588//GO:0006816//GO:0009401 synaptic vesicle endocytosis//calcium ion transmembrane transport//calcium ion transport//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005262 calcium channel activity GO:0030285//GO:0016021 integral component of synaptic vesicle membrane//integral component of membrane KOG4085 Uncharacterized conserved protein Cluster-8309.202 BP_3 7.00 0.43 1071 755892032 XP_011295016.1 812 4.8e-84 PREDICTED: putative nuclease HARBI1 [Musca domestica] -- -- -- -- -- -- -- -- -- Q96MB7 173 2.5e-11 Putative nuclease HARBI1 OS=Homo sapiens GN=HARBI1 PE=1 SV=1 PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.20200 BP_3 91.25 4.34 1306 -- -- -- -- -- 642938592 XM_008201634.1 158 8.58303e-75 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X9, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20201 BP_3 66.59 1.09 3242 642937773 XP_008198939.1 1921 3.7e-212 PREDICTED: probable phospholipid-transporting ATPase IM isoform X1 [Tribolium castaneum]>gi|270000767|gb|EEZ97214.1| hypothetical protein TcasGA2_TC011007 [Tribolium castaneum] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 Q8TF62 1173 8.3e-127 Probable phospholipid-transporting ATPase IM OS=Homo sapiens GN=ATP8B4 PE=1 SV=3 -- -- GO:0015914//GO:0015917//GO:0006812 phospholipid transport//aminophospholipid transport//cation transport GO:0004012//GO:0015662//GO:0005524//GO:0000287 phospholipid-translocating ATPase activity//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//ATP binding//magnesium ion binding GO:0016021 integral component of membrane KOG0206 P-type ATPase Cluster-8309.20202 BP_3 156.81 2.51 3308 478252419 ENN72843.1 1917 1.1e-211 hypothetical protein YQE_10523, partial [Dendroctonus ponderosae]>gi|546677841|gb|ERL88598.1| hypothetical protein D910_05983, partial [Dendroctonus ponderosae] -- -- -- -- -- K18419 DCGR8 microprocessor complex subunit DGCR8 http://www.genome.jp/dbget-bin/www_bget?ko:K18419 A6QR44 819 9.5e-86 Microprocessor complex subunit DGCR8 OS=Bos taurus GN=DGCR8 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4334 Uncharacterized conserved protein, contains double-stranded RNA-binding motif and WW domain Cluster-8309.20203 BP_3 48.00 2.10 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20209 BP_3 50.49 0.36 7087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08074 CHDCT2 (NUC038) domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0008270//GO:0003677//GO:0016818 ATP binding//zinc ion binding//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus -- -- Cluster-8309.2021 BP_3 3.00 0.43 631 545487328 XP_533590.3 938 7.0e-99 PREDICTED: 40S ribosomal protein S9 [Canis lupus familiaris] 45786139 BC068055.1 597 0 Homo sapiens ribosomal protein S9, mRNA (cDNA clone MGC:78492 IMAGE:5454636), complete cds K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 A6QLG5 928 4.1e-99 40S ribosomal protein S9 OS=Bos taurus GN=RPS9 PE=2 SV=1 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain -- -- GO:0019843//GO:0003723 rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.20213 BP_3 24.00 1.16 1286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20217 BP_3 404.25 6.17 3451 478263614 ENN81920.1 2165 2.0e-240 hypothetical protein YQE_01631, partial [Dendroctonus ponderosae] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 766 1.4e-79 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.20219 BP_3 3.00 0.39 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2022 BP_3 5.00 0.32 1052 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20224 BP_3 487.17 5.65 4444 642922938 XP_008200459.1 3758 0.0e+00 PREDICTED: symplekin [Tribolium castaneum]>gi|270006545|gb|EFA02993.1| hypothetical protein TcasGA2_TC010414 [Tribolium castaneum] -- -- -- -- -- K06100 SYMPK symplekin http://www.genome.jp/dbget-bin/www_bget?ko:K06100 Q8MSU4 1770 6.8e-196 Symplekin OS=Drosophila melanogaster GN=Sym PE=1 SV=1 PF10392//PF00312//PF04111//PF14764 Golgi transport complex subunit 5//Ribosomal protein S15//Autophagy protein Apg6//AP-5 complex subunit, vesicle trafficking GO:0006891//GO:0006412//GO:0006914//GO:0042254 intra-Golgi vesicle-mediated transport//translation//autophagy//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0044599//GO:0005622//GO:0017119//GO:0005840 AP-5 adaptor complex//intracellular//Golgi transport complex//ribosome KOG1895 mRNA cleavage and polyadenylation factor II complex, subunit PTA1 Cluster-8309.20227 BP_3 26.09 1.19 1345 270013786 EFA10234.1 357 3.5e-31 hypothetical protein TcasGA2_TC012431 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20229 BP_3 89.71 2.37 2120 546679518 ERL89973.1 762 6.0e-78 hypothetical protein D910_07332 [Dendroctonus ponderosae] -- -- -- -- -- K17583 NOM1 nucleolar MIF4G domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17583 Q9W020 474 6.2e-46 Nucleolar MIF4G domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG9004 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2141 Protein involved in high osmolarity signaling pathway Cluster-8309.20230 BP_3 1135.29 21.17 2877 478250620 ENN71112.1 1970 6.9e-218 hypothetical protein YQE_12045, partial [Dendroctonus ponderosae] -- -- -- -- -- K17583 NOM1 nucleolar MIF4G domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17583 Q9W020 1263 2.7e-137 Nucleolar MIF4G domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG9004 PE=2 SV=1 PF02854 MIF4G domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2141 Protein involved in high osmolarity signaling pathway Cluster-8309.20231 BP_3 182.93 2.28 4154 478253799 ENN74091.1 4824 0.0e+00 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 P29144 2726 8.9e-307 Tripeptidyl-peptidase 2 OS=Homo sapiens GN=TPP2 PE=1 SV=4 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.20233 BP_3 35.92 0.77 2543 478253799 ENN74091.1 605 1.2e-59 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 Q9V6K1 357 2.7e-32 Tripeptidyl-peptidase 2 OS=Drosophila melanogaster GN=TppII PE=1 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.20235 BP_3 379.38 13.85 1612 642933484 XP_973892.2 1487 3.9e-162 PREDICTED: soluble calcium-activated nucleotidase 1 [Tribolium castaneum] -- -- -- -- -- K12304 CANT1 soluble calcium-activated nucleotidase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12304 Q8VCF1 809 6.7e-85 Soluble calcium-activated nucleotidase 1 OS=Mus musculus GN=Cant1 PE=2 SV=1 PF06079 Apyrase -- -- GO:0016462//GO:0005509 pyrophosphatase activity//calcium ion binding -- -- KOG4494 Cell surface ATP diphosphohydrolase Apyrase Cluster-8309.20237 BP_3 6.00 0.42 984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20238 BP_3 227.63 3.32 3597 3127936 CAA06690.1 1930 3.7e-213 nuclear receptor [Tenebrio molitor] -- -- -- -- -- K08544 NR2C2, TR4 testicular receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08544 P55094 913 1.3e-96 Nuclear receptor subfamily 2 group C member 2 OS=Rattus norvegicus GN=Nr2c2 PE=2 SV=1 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.2024 BP_3 141.00 7.66 1179 642924402 XP_008194281.1 980 1.8e-103 PREDICTED: uncharacterized protein LOC100142362 [Tribolium castaneum]>gi|270007895|gb|EFA04343.1| hypothetical protein TcasGA2_TC014638 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01146 Caveolin GO:0070836 caveola assembly -- -- -- -- -- -- Cluster-8309.20244 BP_3 261.74 2.84 4741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20255 BP_3 91.00 5.09 1154 189237999 XP_001812951.1 879 8.9e-92 PREDICTED: mediator of RNA polymerase II transcription subunit 20 [Tribolium castaneum]>gi|270006649|gb|EFA03097.1| hypothetical protein TcasGA2_TC013006 [Tribolium castaneum] -- -- -- -- -- K13528 MED20 mediator of RNA polymerase II transcription subunit 20 http://www.genome.jp/dbget-bin/www_bget?ko:K13528 Q17LR9 704 7.2e-73 Mediator of RNA polymerase II transcription subunit 20 OS=Aedes aegypti GN=MED20 PE=3 SV=1 PF08612 TATA-binding related factor (TRF) of subunit 20 of Mediator complex GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4309 Transcription mediator-related factor Cluster-8309.20256 BP_3 11.00 0.43 1523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20258 BP_3 14.17 0.33 2355 270004464 EFA00912.1 525 2.0e-50 hypothetical protein TcasGA2_TC003818 [Tribolium castaneum] 642917680 XM_008193104.1 52 1.31843e-15 PREDICTED: Tribolium castaneum poly(A) polymerase type 3 (LOC103312455), transcript variant X2, mRNA K14376 PAP poly(A) polymerase http://www.genome.jp/dbget-bin/www_bget?ko:K14376 Q6PCL9 371 6.0e-34 Poly(A) polymerase gamma OS=Mus musculus GN=Papolg PE=1 SV=1 PF04928//PF04926 Poly(A) polymerase central domain//Poly(A) polymerase predicted RNA binding domain GO:0043631 RNA polyadenylation GO:0004652//GO:0003723 polynucleotide adenylyltransferase activity//RNA binding -- -- KOG2245 Poly(A) polymerase and related nucleotidyltransferases Cluster-8309.2026 BP_3 123.00 7.97 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20260 BP_3 29.00 1.66 1134 91078316 XP_972782.1 831 3.2e-86 PREDICTED: probable methyltransferase BTM2 homolog [Tribolium castaneum]>gi|270003957|gb|EFA00405.1| hypothetical protein TcasGA2_TC003256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W138 616 1.1e-62 Probable methyltransferase BTM2 homolog OS=Drosophila melanogaster GN=CG3570 PE=2 SV=1 PF11968//PF08241 Putative methyltransferase (DUF3321)//Methyltransferase domain GO:0008152//GO:0006396//GO:0000154 metabolic process//RNA processing//rRNA modification GO:0016433//GO:0008168 rRNA (adenine) methyltransferase activity//methyltransferase activity -- -- -- -- Cluster-8309.20261 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20263 BP_3 168.00 6.88 1468 478256346 ENN76536.1 297 3.5e-24 hypothetical protein YQE_06987, partial [Dendroctonus ponderosae]>gi|546680776|gb|ERL90982.1| hypothetical protein D910_08324 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20267 BP_3 192.74 1.64 5947 91090340 XP_967097.1 1862 4.7e-205 PREDICTED: hexosaminidase D [Tribolium castaneum]>gi|270013820|gb|EFA10268.1| hypothetical protein TcasGA2_TC012468 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 807 4.2e-84 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728//PF02259 Glycosyl hydrolase family 20, catalytic domain//FAT domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//protein binding -- -- -- -- Cluster-8309.20269 BP_3 9.00 0.79 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03494 Beta-amyloid peptide (beta-APP) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20271 BP_3 33.70 0.67 2708 828235266 XP_012566344.1 653 3.4e-65 PREDICTED: tigger transposable element-derived protein 1-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08671//PF04218//PF03184//PF05225//PF02232 Anti-repressor SinI//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease//helix-turn-helix, Psq domain//Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0003677//GO:0003676 protein dimerization activity//DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.20274 BP_3 246.92 1.78 6963 642938364 XP_008198852.1 1323 1.8e-142 PREDICTED: receptor-type tyrosine-protein phosphatase F-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EQS9 217 1.3e-15 Immunoglobulin superfamily DCC subclass member 4 OS=Mus musculus GN=Igdcc4 PE=2 SV=1 PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.20279 BP_3 53.95 1.02 2849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20280 BP_3 155.22 6.70 1409 189237225 XP_001810464.1 1004 3.5e-106 PREDICTED: inhibitor of growth protein 5 isoform X3 [Tribolium castaneum] 170041067 XM_001848247.1 126 5.70405e-57 Culex quinquefasciatus inhibitor of growth protein, ing4, mRNA K11346 ING4 inhibitor of growth protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11346 Q5ZKY4 692 2.2e-71 Inhibitor of growth protein 4 OS=Gallus gallus GN=ING4 PE=2 SV=1 PF06320//PF00103//PF00628 GCN5-like protein 1 (GCN5L1)//Somatotropin hormone family//PHD-finger GO:0007165 signal transduction GO:0005179//GO:0005515 hormone activity//protein binding GO:0031083//GO:0005576 BLOC-1 complex//extracellular region KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.20282 BP_3 470.79 4.23 5661 429544803 AGA01579.1 2323 1.6e-258 cryptochrome 2 [Rhyparobia maderae] 801397565 XM_012203803.1 258 9.76759e-130 PREDICTED: Atta cephalotes cryptochrome-1-like (LOC105622379), mRNA K02295 CRY cryptochrome http://www.genome.jp/dbget-bin/www_bget?ko:K02295 P97784 1966 1.6e-218 Cryptochrome-1 OS=Mus musculus GN=Cry1 PE=1 SV=1 PF16866//PF13912//PF01363//PF00096//PF13465 PHD-finger//C2H2-type zinc finger//FYVE zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- KOG0133 Deoxyribodipyrimidine photolyase/cryptochrome Cluster-8309.20285 BP_3 6.95 0.56 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20287 BP_3 9.00 1.09 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20288 BP_3 6.00 0.66 733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20289 BP_3 10.00 0.62 1067 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20291 BP_3 14.09 0.42 1906 270015218 EFA11666.1 244 6.3e-18 hypothetical protein TcasGA2_TC008530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW3 162 8.4e-10 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF13855//PF08163 Leucine rich repeat//NUC194 domain GO:0006303//GO:0016310//GO:0009069 double-strand break repair via nonhomologous end joining//phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0003677//GO:0004677//GO:0005524 protein binding//DNA binding//DNA-dependent protein kinase activity//ATP binding GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0619 FOG: Leucine rich repeat Cluster-8309.20296 BP_3 21.26 0.45 2589 642935034 XP_008199914.1 150 6.8e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 198 1.00193e-96 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF10186//PF02841//PF05835//PF03938//PF04111 Vacuolar sorting 38 and autophagy-related subunit 14//Guanylate-binding protein, C-terminal domain//Synaphin protein//Outer membrane protein (OmpH-like)//Autophagy protein Apg6 GO:0006836//GO:0010508//GO:0006914 neurotransmitter transport//positive regulation of autophagy//autophagy GO:0005525//GO:0051082//GO:0019905//GO:0003924 GTP binding//unfolded protein binding//syntaxin binding//GTPase activity -- -- -- -- Cluster-8309.20297 BP_3 94.01 2.12 2425 478252547 ENN72962.1 1070 1.3e-113 hypothetical protein YQE_10414, partial [Dendroctonus ponderosae] -- -- -- -- -- K14590 CMTR2, FTSJD1, AFT cap2 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14590 Q8IYT2 699 5.7e-72 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens GN=CMTR2 PE=1 SV=2 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.20299 BP_3 4.40 0.61 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.203 BP_3 3.00 0.35 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20300 BP_3 449.46 7.58 3149 546680521 ERL90781.1 1999 3.3e-221 hypothetical protein D910_08127 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9HCS5 983 8.7e-105 Band 4.1-like protein 4A OS=Homo sapiens GN=EPB41L4A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.20301 BP_3 40.81 0.68 3171 91089013 XP_968301.1 1751 1.9e-192 PREDICTED: RINT1-like protein [Tribolium castaneum]>gi|270011539|gb|EFA07987.1| hypothetical protein TcasGA2_TC005574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BZ36 755 2.4e-78 RAD50-interacting protein 1 OS=Mus musculus GN=Rint1 PE=2 SV=2 PF06008//PF05384//PF04437//PF08702 Laminin Domain I//Sensor protein DegS//RINT-1 / TIP-1 family//Fibrinogen alpha/beta chain family GO:0045995//GO:0030168//GO:0030155//GO:0048193//GO:0051258//GO:0030334//GO:0007165 regulation of embryonic development//platelet activation//regulation of cell adhesion//Golgi vesicle transport//protein polymerization//regulation of cell migration//signal transduction GO:0016301//GO:0005102//GO:0030674 kinase activity//receptor binding//protein binding, bridging GO:0005577//GO:0005783 fibrinogen complex//endoplasmic reticulum -- -- Cluster-8309.20304 BP_3 140.79 6.01 1421 478254577 ENN74820.1 991 1.1e-104 hypothetical protein YQE_08593, partial [Dendroctonus ponderosae]>gi|546674802|gb|ERL86096.1| hypothetical protein D910_03510 [Dendroctonus ponderosae] -- -- -- -- -- K02357 tsf, TSFM elongation factor Ts http://www.genome.jp/dbget-bin/www_bget?ko:K02357 Q17PI0 810 4.5e-85 Elongation factor Ts, mitochondrial OS=Aedes aegypti GN=AAEL000331 PE=3 SV=1 PF01434//PF00889 Peptidase family M41//Elongation factor TS GO:0006508//GO:0006414//GO:0006448 proteolysis//translational elongation//regulation of translational elongation GO:0003746//GO:0004222//GO:0005524 translation elongation factor activity//metalloendopeptidase activity//ATP binding GO:0005622//GO:0005840 intracellular//ribosome KOG1071 Mitochondrial translation elongation factor EF-Tsmt, catalyzes nucleotide exchange on EF-Tumt Cluster-8309.20305 BP_3 157.21 3.84 2264 478254577 ENN74820.1 1005 4.3e-106 hypothetical protein YQE_08593, partial [Dendroctonus ponderosae]>gi|546674802|gb|ERL86096.1| hypothetical protein D910_03510 [Dendroctonus ponderosae] -- -- -- -- -- K02357 tsf, TSFM elongation factor Ts http://www.genome.jp/dbget-bin/www_bget?ko:K02357 Q17PI0 810 7.2e-85 Elongation factor Ts, mitochondrial OS=Aedes aegypti GN=AAEL000331 PE=3 SV=1 PF01434//PF00889 Peptidase family M41//Elongation factor TS GO:0006414//GO:0006448//GO:0006508 translational elongation//regulation of translational elongation//proteolysis GO:0005524//GO:0004222//GO:0003746 ATP binding//metalloendopeptidase activity//translation elongation factor activity GO:0005622//GO:0005840 intracellular//ribosome KOG1071 Mitochondrial translation elongation factor EF-Tsmt, catalyzes nucleotide exchange on EF-Tumt Cluster-8309.20306 BP_3 209.00 7.66 1607 91092780 XP_973869.1 1099 3.8e-117 PREDICTED: E3 ubiquitin-protein ligase RNF220 [Tribolium castaneum]>gi|270014897|gb|EFA11345.1| hypothetical protein TcasGA2_TC010885 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5VTB9 443 1.8e-42 E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens GN=RNF220 PE=1 SV=1 PF13897//PF13639//PF15750//PF12861//PF14634//PF00097//PF15926 Golgi-dynamics membrane-trafficking//Ring finger domain//Ubiquitin-binding zinc-finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//E3 ubiquitin-protein ligase RNF220 GO:0090263//GO:0016567//GO:0006810 positive regulation of canonical Wnt signaling pathway//protein ubiquitination//transport GO:0008270//GO:0043169//GO:0046872//GO:0043130//GO:0004842//GO:0005515 zinc ion binding//cation binding//metal ion binding//ubiquitin binding//ubiquitin-protein transferase activity//protein binding GO:0016021//GO:0005680 integral component of membrane//anaphase-promoting complex -- -- Cluster-8309.20307 BP_3 419.00 30.63 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20310 BP_3 29.67 0.43 3640 478250371 ENN70866.1 967 1.8e-101 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672861|gb|ERL84584.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 B4F753 618 2.1e-62 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF02230//PF07859//PF00326//PF01764//PF00975 Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family//Lipase (class 3)//Thioesterase domain GO:0006629//GO:0009058//GO:0006508//GO:0008152 lipid metabolic process//biosynthetic process//proteolysis//metabolic process GO:0008236//GO:0016787//GO:0016788 serine-type peptidase activity//hydrolase activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.20312 BP_3 137.68 0.35 19433 642929422 XP_008195833.1 3477 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] 642929421 XM_008197611.1 179 2.77294e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q7TMR0 1024 9.5e-109 Lysosomal Pro-X carboxypeptidase OS=Mus musculus GN=Prcp PE=2 SV=2 PF00326//PF00400//PF00439//PF00536//PF00130//PF04574//PF00628//PF14634//PF00076//PF16367//PF05577//PF01429//PF08273//PF01221//PF01609//PF08926//PF11789//PF07647//PF06638//PF04564//PF02198 Prolyl oligopeptidase family//WD domain, G-beta repeat//Bromodomain//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein of unknown function (DUF592)//PHD-finger//zinc-RING finger domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Serine carboxypeptidase S28//Methyl-CpG binding domain//Zinc-binding domain of primase-helicase//Dynein light chain type 1//Transposase DDE domain//Domain of unknown function (DUF1908)//Zinc-finger of the MIZ type in Nse subunit//SAM domain (Sterile alpha motif)//Strabismus protein//U-box domain//Sterile alpha motif (SAM)/Pointed domain GO:0016567//GO:0016310//GO:0006342//GO:0007275//GO:0006508//GO:0035556//GO:0006269//GO:0006313//GO:0006351//GO:0006476//GO:0006807//GO:0009069//GO:0006468//GO:0006355//GO:0007017 protein ubiquitination//phosphorylation//chromatin silencing//multicellular organismal development//proteolysis//intracellular signal transduction//DNA replication, synthesis of RNA primer//transposition, DNA-mediated//transcription, DNA-templated//protein deacetylation//nitrogen compound metabolic process//serine family amino acid metabolic process//protein phosphorylation//regulation of transcription, DNA-templated//microtubule-based process GO:0004842//GO:0004803//GO:0003676//GO:0005524//GO:0008236//GO:0004674//GO:0051287//GO:0005515//GO:0004386//GO:0003677//GO:0000287//GO:0017136//GO:0016811//GO:0003896//GO:0008270//GO:0043565 ubiquitin-protein transferase activity//transposase activity//nucleic acid binding//ATP binding//serine-type peptidase activity//protein serine/threonine kinase activity//NAD binding//protein binding//helicase activity//DNA binding//magnesium ion binding//NAD-dependent histone deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//DNA primase activity//zinc ion binding//sequence-specific DNA binding GO:0000118//GO:0005730//GO:0005657//GO:0005634//GO:0016021//GO:0005875 histone deacetylase complex//nucleolus//replication fork//nucleus//integral component of membrane//microtubule associated complex KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.20314 BP_3 468.22 6.99 3522 332373100 AEE61691.1 1682 2.1e-184 unknown [Dendroctonus ponderosae] 642911564 XM_008201254.1 402 0 PREDICTED: Tribolium castaneum casein kinase II subunit alpha-like (LOC660746), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 3.2e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.20317 BP_3 13.52 0.37 2052 642913410 XP_008200999.1 550 2.2e-53 PREDICTED: nicotinic acetylcholine receptor alpha1 subunit isoform X2 [Tribolium castaneum] -- -- -- -- -- K04805 CHRNA3 nicotinic acetylcholine receptor alpha-3 http://www.genome.jp/dbget-bin/www_bget?ko:K04805 P09478 503 2.6e-49 Acetylcholine receptor subunit alpha-like 1 OS=Drosophila melanogaster GN=nAChRalpha1 PE=2 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.20321 BP_3 111.64 2.80 2211 91092532 XP_967540.1 1599 5.5e-175 PREDICTED: ankyrin-1 [Tribolium castaneum]>gi|270006612|gb|EFA03060.1| hypothetical protein TcasGA2_TC010916 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 306 1.9e-26 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF07525//PF00023//PF13606 SOCS box//Ankyrin repeat//Ankyrin repeat GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.20326 BP_3 5.00 0.73 621 60300016 AAX18656.1 317 7.0e-27 cysteine-rich protein [Apriona germari] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.20327 BP_3 149.69 2.79 2877 642916212 XP_008190932.1 3596 0.0e+00 PREDICTED: nuclear pore complex protein Nup205 [Tribolium castaneum]>gi|270004157|gb|EFA00605.1| hypothetical protein TcasGA2_TC003479 [Tribolium castaneum] -- -- -- -- -- K14310 NUP205, NUP192 nuclear pore complex protein Nup205 http://www.genome.jp/dbget-bin/www_bget?ko:K14310 Q92621 1639 6.8e-181 Nuclear pore complex protein Nup205 OS=Homo sapiens GN=NUP205 PE=1 SV=3 PF11894 Nuclear pore complex scaffold, nucleoporins 186/192/205 -- -- -- -- GO:0005643 nuclear pore KOG1835 Uncharacterized conserved protein Cluster-8309.20328 BP_3 319.69 5.48 3106 642916212 XP_008190932.1 3597 0.0e+00 PREDICTED: nuclear pore complex protein Nup205 [Tribolium castaneum]>gi|270004157|gb|EFA00605.1| hypothetical protein TcasGA2_TC003479 [Tribolium castaneum] -- -- -- -- -- K14310 NUP205, NUP192 nuclear pore complex protein Nup205 http://www.genome.jp/dbget-bin/www_bget?ko:K14310 Q92621 1639 7.3e-181 Nuclear pore complex protein Nup205 OS=Homo sapiens GN=NUP205 PE=1 SV=3 PF11894 Nuclear pore complex scaffold, nucleoporins 186/192/205 -- -- -- -- GO:0005643 nuclear pore KOG1835 Uncharacterized conserved protein Cluster-8309.20329 BP_3 677.29 11.64 3097 642916212 XP_008190932.1 2924 0.0e+00 PREDICTED: nuclear pore complex protein Nup205 [Tribolium castaneum]>gi|270004157|gb|EFA00605.1| hypothetical protein TcasGA2_TC003479 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92621 823 3.1e-86 Nuclear pore complex protein Nup205 OS=Homo sapiens GN=NUP205 PE=1 SV=3 PF11894 Nuclear pore complex scaffold, nucleoporins 186/192/205 -- -- -- -- GO:0005643 nuclear pore -- -- Cluster-8309.20330 BP_3 28.36 0.32 4605 270014503 EFA10951.1 4363 0.0e+00 hypothetical protein TcasGA2_TC004111 [Tribolium castaneum] 462333089 APGK01039098.1 75 4.25232e-28 Dendroctonus ponderosae Seq01039108, whole genome shotgun sequence K11665 INO80, INOC1 DNA helicase INO80 http://www.genome.jp/dbget-bin/www_bget?ko:K11665 Q9VDY1 2638 1.6e-296 Putative DNA helicase Ino80 OS=Drosophila melanogaster GN=Ino80 PE=1 SV=2 PF13892//PF00176 DNA-binding domain//SNF2 family N-terminal domain -- -- GO:0003677//GO:0005524 DNA binding//ATP binding -- -- KOG0388 SNF2 family DNA-dependent ATPase Cluster-8309.20341 BP_3 13.88 0.85 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06416 Protein of unknown function (DUF1076) GO:0016567//GO:0072519 protein ubiquitination//parasitism GO:0004842 ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.20342 BP_3 3.00 2.34 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20344 BP_3 323.35 11.98 1593 642936522 XP_008198471.1 794 8.8e-82 PREDICTED: BRCA1-A complex subunit BRE-like [Tribolium castaneum]>gi|270014127|gb|EFA10575.1| hypothetical protein TcasGA2_TC012831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6SP92 377 8.2e-35 BRCA1-A complex subunit BRE OS=Mesocricetus auratus GN=Bre PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20345 BP_3 15.87 0.78 1267 642936522 XP_008198471.1 491 9.6e-47 PREDICTED: BRCA1-A complex subunit BRE-like [Tribolium castaneum]>gi|270014127|gb|EFA10575.1| hypothetical protein TcasGA2_TC012831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B6NXD5 219 1.4e-16 BRCA1-A complex subunit BRE OS=Branchiostoma floridae GN=BRE PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20347 BP_3 99.06 13.44 647 270011377 EFA07825.1 445 1.1e-41 hypothetical protein TcasGA2_TC005394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KM2 237 5.7e-19 Protein C10 OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20348 BP_3 126.94 6.13 1290 270011377 EFA07825.1 445 2.1e-41 hypothetical protein TcasGA2_TC005394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KM2 237 1.1e-18 Protein C10 OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20350 BP_3 13.00 1.00 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20351 BP_3 50.00 4.90 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20353 BP_3 150.40 1.87 4159 642935912 XP_008198226.1 1993 2.1e-220 PREDICTED: BMP-binding endothelial regulator protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8U9 947 1.7e-100 BMP-binding endothelial regulator protein OS=Homo sapiens GN=BMPER PE=1 SV=3 PF01479//PF00093 S4 domain//von Willebrand factor type C domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.20355 BP_3 9.92 3.07 447 805809013 XP_012146731.1 162 4.7e-09 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X3 [Megachile rotundata] -- -- -- -- -- -- -- -- -- P91660 129 1.3e-06 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.20357 BP_3 18.65 0.47 2220 270007722 EFA04170.1 456 1.9e-42 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 236 2.6e-18 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.20358 BP_3 229.20 9.73 1427 91083111 XP_970182.1 1198 1.1e-128 PREDICTED: L-galactose dehydrogenase [Tribolium castaneum]>gi|270007677|gb|EFA04125.1| hypothetical protein TcasGA2_TC014368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O81884 513 1.2e-50 L-galactose dehydrogenase OS=Arabidopsis thaliana GN=LGALDH PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1576 Predicted oxidoreductase Cluster-8309.20359 BP_3 2.00 0.43 516 270011231 EFA07679.1 254 1.2e-19 hypothetical protein TcasGA2_TC030712 [Tribolium castaneum] -- -- -- -- -- K14026 SEL1, SEL1L SEL1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14026 Q9UBV2 165 1.0e-10 Protein sel-1 homolog 1 OS=Homo sapiens GN=SEL1L PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1550 Extracellular protein SEL-1 and related proteins Cluster-8309.2036 BP_3 2.00 0.74 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20362 BP_3 68.00 275.07 270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20363 BP_3 3798.00 599.57 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02970//PF05818//PF07851//PF04111//PF05279 Tubulin binding cofactor A//Enterobacterial TraT complement resistance protein//TMPIT-like protein//Autophagy protein Apg6//Aspartyl beta-hydroxylase N-terminal region GO:0007021//GO:0046999//GO:0006914 tubulin complex assembly//regulation of conjugation//autophagy GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0016020//GO:0016021//GO:0019867//GO:0045298 membrane//integral component of membrane//outer membrane//tubulin complex -- -- Cluster-8309.20364 BP_3 24.94 0.50 2691 189236049 XP_001809395.1 503 8.2e-48 PREDICTED: tudor domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- K18404 TDRD3 tudor domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18404 Q5ZMS6 336 7.9e-30 Tudor domain-containing protein 3 OS=Gallus gallus GN=TDRD3 PE=2 SV=1 PF09103//PF06003 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1//Survival motor neuron protein (SMN) GO:0006397//GO:0000724 mRNA processing//double-strand break repair via homologous recombination GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG3683 Uncharacterized conserved protein Cluster-8309.20365 BP_3 41.06 0.67 3247 255522797 NP_001157311.1 295 1.3e-23 longitudinals lacking isoform 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 142 3.0e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20368 BP_3 104.55 1.55 3551 642922747 XP_008193307.1 1618 5.6e-177 PREDICTED: MAGUK p55 subfamily member 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14168 779 4.4e-81 MAGUK p55 subfamily member 2 OS=Homo sapiens GN=MPP2 PE=1 SV=3 PF13180//PF00595//PF14604//PF00018//PF03193 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Variant SH3 domain//SH3 domain//Protein of unknown function, DUF258 -- -- GO:0005515//GO:0003924//GO:0005525 protein binding//GTPase activity//GTP binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.20369 BP_3 1.76 1.27 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20370 BP_3 70.67 1.03 3603 642923250 XP_008193676.1 2810 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 95 2.53028e-39 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 1531 2.8e-168 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF00023//PF00097//PF13606//PF07649//PF06701//PF00569 Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//C1-like domain//Mib_herc2//Zinc finger, ZZ type GO:0055114//GO:0016567 oxidation-reduction process//protein ubiquitination GO:0004842//GO:0047134//GO:0046872//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//protein-disulfide reductase activity//metal ion binding//protein binding//zinc ion binding -- -- -- -- Cluster-8309.20371 BP_3 858.00 9.19 4790 91080987 XP_974999.1 2988 0.0e+00 PREDICTED: WD repeat-containing protein 48 homolog [Tribolium castaneum] -- -- -- -- -- K15361 WDR48, UAF1 WD repeat-containing protein 48 http://www.genome.jp/dbget-bin/www_bget?ko:K15361 Q16MY0 1948 1.7e-216 WD repeat-containing protein 48 homolog OS=Aedes aegypti GN=AAEL012158 PE=3 SV=1 PF03079//PF02311//PF00400 ARD/ARD' family//AraC-like ligand binding domain//WD domain, G-beta repeat GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0010309//GO:0005515 acireductone dioxygenase [iron(II)-requiring] activity//protein binding -- -- KOG0308 Conserved WD40 repeat-containing protein Cluster-8309.20372 BP_3 62.00 8.18 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20373 BP_3 394.49 7.92 2694 91081805 XP_974174.1 1438 3.1e-156 PREDICTED: equilibrative nucleoside transporter 3 [Tribolium castaneum]>gi|270006294|gb|EFA02742.1| hypothetical protein TcasGA2_TC008473 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 553 5.4e-55 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733//PF07247 Nucleoside transporter//Alcohol acetyltransferase GO:0042967//GO:0006810//GO:0006066//GO:0015858 acyl-carrier-protein biosynthetic process//transport//alcohol metabolic process//nucleoside transport GO:0004026//GO:0005337 alcohol O-acetyltransferase activity//nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.20375 BP_3 275.38 5.17 2857 795013623 XP_011883597.1 900 8.1e-94 PREDICTED: uncharacterized protein LOC105570767 isoform X2 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 178 1.7e-11 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.20379 BP_3 575.24 12.28 2550 91083363 XP_975142.1 1914 1.9e-211 PREDICTED: diacylglycerol O-acyltransferase 1 [Tribolium castaneum]>gi|270007773|gb|EFA04221.1| hypothetical protein TcasGA2_TC014471 [Tribolium castaneum] -- -- -- -- -- K11155 DGAT1 diacylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11155 Q9Z2A7 996 2.2e-106 Diacylglycerol O-acyltransferase 1 OS=Mus musculus GN=Dgat1 PE=1 SV=1 -- -- GO:0042967 acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0380 Sterol O-acyltransferase/Diacylglycerol O-acyltransferase Cluster-8309.20381 BP_3 2.00 15.06 251 123389586 XP_001299746.1 203 4.7e-14 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121880660|gb|EAX86816.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q4UMH6 171 9.9e-12 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20388 BP_3 23.12 0.58 2228 546683467 ERL93273.1 1208 1.2e-129 hypothetical protein D910_10569, partial [Dendroctonus ponderosae] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 2.7e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF04277//PF07525 Oxaloacetate decarboxylase, gamma chain//SOCS box GO:0006525//GO:0006560//GO:0071436//GO:0006090//GO:0006814//GO:0035556 arginine metabolic process//proline metabolic process//sodium ion export//pyruvate metabolic process//sodium ion transport//intracellular signal transduction GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.20389 BP_3 541.47 9.37 3077 478255137 ENN75367.1 1626 5.7e-178 hypothetical protein YQE_08142, partial [Dendroctonus ponderosae] 642914874 XM_965920.3 58 7.98121e-19 PREDICTED: Tribolium castaneum protein inscuteable homolog (LOC659633), mRNA -- -- -- -- Q3HNM7 345 8.1e-31 Protein inscuteable homolog OS=Mus musculus GN=Insc PE=1 SV=2 PF00514//PF01066 Armadillo/beta-catenin-like repeat//CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0005515//GO:0016780 protein binding//phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane -- -- Cluster-8309.20394 BP_3 1023.63 14.69 3650 642934335 XP_969733.2 2984 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X5 [Tribolium castaneum] 817086197 XM_012410395.1 92 1.19274e-37 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 448 1.1e-42 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF09815//PF05524//PF01436//PF14634//PF00643//PF05929//PF00097//PF02601//PF01580//PF13639//PF05149//PF01637 XK-related protein//PEP-utilising enzyme, N-terminal//NHL repeat//zinc-RING finger domain//B-box zinc finger//Phage capsid scaffolding protein (GPO) serine peptidase//Zinc finger, C3HC4 type (RING finger)//Exonuclease VII, large subunit//FtsK/SpoIIIE family//Ring finger domain//Paraflagellar rod protein//Archaeal ATPase GO:0006308//GO:0019069//GO:0009401 DNA catabolic process//viral capsid assembly//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0046872//GO:0008270//GO:0000166//GO:0008855//GO:0005515//GO:0005524//GO:0005516//GO:0003677 metal ion binding//zinc ion binding//nucleotide binding//exodeoxyribonuclease VII activity//protein binding//ATP binding//calmodulin binding//DNA binding GO:0009318//GO:0005622//GO:0016021//GO:0031514 exodeoxyribonuclease VII complex//intracellular//integral component of membrane//motile cilium -- -- Cluster-8309.20397 BP_3 44.85 0.93 2608 91083569 XP_967824.1 831 7.4e-86 PREDICTED: transport and Golgi organization protein 11 [Tribolium castaneum]>gi|270007821|gb|EFA04269.1| hypothetical protein TcasGA2_TC014559 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q961C9 347 4.0e-31 Transport and Golgi organization protein 11 OS=Drosophila melanogaster GN=Tango11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20399 BP_3 57.54 0.76 3928 546681046 ERL91211.1 1248 4.9e-134 hypothetical protein D910_08549 [Dendroctonus ponderosae] -- -- -- -- -- K15119 SLC25A39_40 solute carrier family 25, member 39/40 http://www.genome.jp/dbget-bin/www_bget?ko:K15119 Q6DHC3 920 2.2e-97 Solute carrier family 25 member 40 OS=Danio rerio GN=slc25a40 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0761 Mitochondrial carrier protein CGI-69 Cluster-8309.2040 BP_3 5.00 0.45 823 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20404 BP_3 358.93 5.08 3696 189235566 XP_970111.2 1374 1.1e-148 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q86KF9 297 3.6e-25 Sphingosine kinase A OS=Dictyostelium discoideum GN=sgkA PE=2 SV=2 PF03838 Recombination protein U GO:0007205//GO:0009395//GO:0006310//GO:0006281//GO:0046486 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//DNA recombination//DNA repair//glycerolipid metabolic process GO:0004143 diacylglycerol kinase activity GO:0005737 cytoplasm KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.20405 BP_3 119.07 1.65 3769 189235566 XP_970111.2 1374 1.2e-148 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q86KF9 297 3.7e-25 Sphingosine kinase A OS=Dictyostelium discoideum GN=sgkA PE=2 SV=2 PF03838 Recombination protein U GO:0006281//GO:0046486//GO:0006310//GO:0007205//GO:0009395 DNA repair//glycerolipid metabolic process//DNA recombination//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process GO:0004143 diacylglycerol kinase activity GO:0005737 cytoplasm KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.20406 BP_3 60.94 3.26 1192 189235566 XP_970111.2 1019 5.3e-108 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q9JIA7 216 2.9e-16 Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2 PF00781 Diacylglycerol kinase catalytic domain GO:0009395//GO:0007205//GO:0046486 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//glycerolipid metabolic process GO:0004143//GO:0016301 diacylglycerol kinase activity//kinase activity -- -- KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.20407 BP_3 46.00 0.84 2943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20408 BP_3 6.00 1.56 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20409 BP_3 89.18 2.60 1944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20417 BP_3 248.08 3.61 3608 642923250 XP_008193676.1 4520 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 237 2.92693e-118 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 2033 1.8e-226 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF13639//PF06701//PF00569//PF00023//PF00097//PF13606//PF07649 Ring finger domain//Mib_herc2//Zinc finger, ZZ type//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//C1-like domain GO:0055114//GO:0016567 oxidation-reduction process//protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0047134//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//protein-disulfide reductase activity//metal ion binding -- -- -- -- Cluster-8309.20418 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2042 BP_3 17.00 1.34 904 550540770 G9JJU2.1 630 5.2e-63 RecName: Full=Glutathione peroxidase; Short=PcGPx; Short=Se-PcGPx [Procambarus clarkii]>gi|358357317|gb|AEU08498.1| selenium-dependent glutathione peroxidase [Procambarus clarkii] -- -- -- -- -- K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 G9JJU2 630 2.1e-64 Glutathione peroxidase OS=Procambarus clarkii GN=GPx PE=2 SV=1 PF00255 Glutathione peroxidase GO:0006749//GO:0055114//GO:0006804//GO:0006979 glutathione metabolic process//oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress GO:0004602 glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-8309.20424 BP_3 9.12 0.58 1050 332373900 AEE62091.1 659 2.6e-66 unknown [Dendroctonus ponderosae]>gi|546677358|gb|ERL88215.1| hypothetical protein D910_05603 [Dendroctonus ponderosae] 686803186 LM223515.1 42 2.09204e-10 Strongylus vulgaris genome assembly S_vulgaris_Kentucky ,scaffold SVUK_scaffold0011471 K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q91V37 499 3.8e-49 V-type proton ATPase 21 kDa proteolipid subunit OS=Mus musculus GN=Atp6v0b PE=1 SV=1 PF00137 ATP synthase subunit C GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.20428 BP_3 1.00 1.40 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20429 BP_3 144.27 12.19 862 270006684 EFA03132.1 743 3.9e-76 hypothetical protein TcasGA2_TC013044 [Tribolium castaneum] 642924851 XM_008195844.1 184 1.96943e-89 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- Q9Y266 547 8.6e-55 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.2043 BP_3 7.00 0.47 1008 189234095 XP_967232.2 755 1.9e-77 PREDICTED: neuropeptide Y receptor type 2 [Tribolium castaneum]>gi|270002890|gb|EEZ99337.1| hypothetical protein TcasGA2_TC004565 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.20434 BP_3 13.27 0.39 1943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20435 BP_3 18.16 0.37 2647 642920871 XP_008192594.1 1610 3.5e-176 PREDICTED: protein turtle isoform X9 [Tribolium castaneum]>gi|270006125|gb|EFA02573.1| hypothetical protein TcasGA2_TC008291 [Tribolium castaneum] 645007404 XM_008218033.1 69 5.26375e-25 PREDICTED: Nasonia vitripennis protein turtle (LOC100119623), mRNA -- -- -- -- Q967D7 503 3.3e-49 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20437 BP_3 1.00 1.30 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20438 BP_3 24.26 8.79 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20439 BP_3 16.57 1.22 947 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03335 Phage tail fibre repeat -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.20440 BP_3 27.00 0.50 2897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20441 BP_3 10.00 0.69 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20444 BP_3 8.99 0.55 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20446 BP_3 5.02 0.39 907 91080611 XP_974119.1 150 2.4e-07 PREDICTED: histone deacetylase complex subunit SAP30 homolog [Tribolium castaneum]>gi|270005819|gb|EFA02267.1| hypothetical protein TcasGA2_TC007931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29IK8 127 4.5e-06 Histone deacetylase complex subunit SAP30 homolog OS=Drosophila pseudoobscura pseudoobscura GN=Sap30 PE=3 SV=1 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20448 BP_3 27.00 1.21 1369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20449 BP_3 16.92 0.49 1972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2045 BP_3 988.00 52.60 1197 189234118 XP_001811130.1 531 2.1e-51 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20454 BP_3 92.00 3.42 1589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20457 BP_3 24.00 6.90 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20458 BP_3 8.49 0.42 1269 642932654 XP_008196934.1 300 1.3e-24 PREDICTED: centromere protein F-like [Tribolium castaneum]>gi|642932656|ref|XP_008196935.1| PREDICTED: centromere protein F-like [Tribolium castaneum]>gi|642932658|ref|XP_008196936.1| PREDICTED: centromere protein F-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20459 BP_3 308.73 7.25 2345 546682401 ERL92343.1 1201 8.3e-129 hypothetical protein D910_09660 [Dendroctonus ponderosae] -- -- -- -- -- K14648 ENDOU, PP11 poly(U)-specific endoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K14648 Q9VZ49 735 3.7e-76 Poly(U)-specific endoribonuclease homolog OS=Drosophila melanogaster GN=CG2145 PE=1 SV=1 PF09412 Endoribonuclease XendoU -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2849 Placental protein 11 Cluster-8309.2046 BP_3 102.03 0.65 7877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20462 BP_3 542.00 7.25 3895 646716227 KDR19556.1 2498 5.5e-279 Protein ariadne-1 [Zootermopsis nevadensis] 642911729 XM_008202494.1 547 0 PREDICTED: Tribolium castaneum protein ariadne-1 (LOC660216), mRNA K11968 ARIH1 ariadne-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11968 Q94981 2084 2.3e-232 Protein ariadne-1 OS=Drosophila melanogaster GN=ari-1 PE=1 SV=2 PF13639//PF00097 Ring finger domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.20469 BP_3 117.06 2.34 2698 766933019 XP_011498756.1 677 5.5e-68 PREDICTED: zinc finger protein 836-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- A2CE44 508 9.0e-50 Zinc finger X-linked protein ZXDB OS=Mus musculus GN=Zxdb PE=2 SV=1 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.2047 BP_3 9.00 0.96 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20470 BP_3 3.00 5.92 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20477 BP_3 15.34 0.57 1580 91079869 XP_967328.1 1728 4.3e-190 PREDICTED: JNK-interacting protein 1 [Tribolium castaneum]>gi|270003280|gb|EEZ99727.1| hypothetical protein TcasGA2_TC002493 [Tribolium castaneum] 642918276 XM_962235.3 413 0 PREDICTED: Tribolium castaneum JNK-interacting protein 1 (LOC655673), mRNA K04434 MAPK8IP1, JIP1 mitogen-activated protein kinase 8 interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04434 Q9W0K0 1113 3.7e-120 JNK-interacting protein 1 OS=Drosophila melanogaster GN=Aplip1 PE=1 SV=2 PF00640//PF08416//PF14604//PF00018//PF14719 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Variant SH3 domain//SH3 domain//Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG3775 Mitogen-activated protein kinase scaffold protein JIP Cluster-8309.20478 BP_3 206.39 2.35 4520 91082383 XP_968748.1 3906 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2657 9.7e-299 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00437//PF00910//PF03193//PF03266//PF00005//PF01637//PF01695//PF13304//PF01372//PF01926//PF00664//PF00931//PF01580//PF02367//PF06414//PF03205 Type II/IV secretion system protein//RNA helicase//Protein of unknown function, DUF258//NTPase//ABC transporter//Archaeal ATPase//IstB-like ATP binding protein//AAA domain, putative AbiEii toxin, Type IV TA system//Melittin//50S ribosome-binding GTPase//ABC transporter transmembrane region//NB-ARC domain//FtsK/SpoIIIE family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Molybdopterin guanine dinucleotide synthesis protein B GO:0055085//GO:0006810//GO:0006777//GO:0009987//GO:0045859//GO:0002949 transmembrane transport//transport//Mo-molybdopterin cofactor biosynthetic process//cellular process//regulation of protein kinase activity//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0098519//GO:0003924//GO:0000166//GO:0016301//GO:0016887//GO:0042626//GO:0003723//GO:0004860//GO:0003677//GO:0043531//GO:0005525//GO:0003724 ATP binding//nucleotide phosphatase activity, acting on free nucleotides//GTPase activity//nucleotide binding//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//RNA binding//protein kinase inhibitor activity//DNA binding//ADP binding//GTP binding//RNA helicase activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.20479 BP_3 547.26 17.31 1816 91076740 XP_973178.1 1038 5.1e-110 PREDICTED: tetraspanin-11 [Tribolium castaneum]>gi|270001854|gb|EEZ98301.1| hypothetical protein TcasGA2_TC000754 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF00335 Oxaloacetate decarboxylase, gamma chain//Tetraspanin family GO:0006525//GO:0006560//GO:0006814//GO:0071436//GO:0006090 arginine metabolic process//proline metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.20480 BP_3 21.99 0.40 2946 91076740 XP_973178.1 804 1.1e-82 PREDICTED: tetraspanin-11 [Tribolium castaneum]>gi|270001854|gb|EEZ98301.1| hypothetical protein TcasGA2_TC000754 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01733//PF04277//PF00335 Nucleoside transporter//Oxaloacetate decarboxylase, gamma chain//Tetraspanin family GO:0071436//GO:0006090//GO:0006814//GO:0006560//GO:0006810//GO:0015858//GO:0006525 sodium ion export//pyruvate metabolic process//sodium ion transport//proline metabolic process//transport//nucleoside transport//arginine metabolic process GO:0005337//GO:0015081//GO:0008948 nucleoside transmembrane transporter activity//sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.20483 BP_3 404.00 10.85 2087 270013287 EFA09735.1 263 4.3e-20 hypothetical protein TcasGA2_TC011868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01857 Retinoblastoma-associated protein B domain GO:0051726 regulation of cell cycle -- -- GO:0005634 nucleus -- -- Cluster-8309.20484 BP_3 11.57 0.68 1107 607356865 EZA51356.1 862 8.0e-90 hypothetical protein X777_10005, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0008408//GO:0003677//GO:0000166//GO:0003887 3'-5' exonuclease activity//DNA binding//nucleotide binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.20485 BP_3 4.00 0.71 564 759051754 XP_011335000.1 460 1.7e-43 PREDICTED: uncharacterized protein LOC105277946 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20486 BP_3 45.00 4.84 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2049 BP_3 8.00 0.60 936 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20491 BP_3 2.00 1.26 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20495 BP_3 80.83 2.03 2208 642938537 XP_008199832.1 1069 1.6e-113 PREDICTED: UDP-xylose and UDP-N-acetylglucosamine transporter [Tribolium castaneum]>gi|270015580|gb|EFA12028.1| hypothetical protein TcasGA2_TC001443 [Tribolium castaneum] -- -- -- -- -- K15278 SLC35B4, YEA4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 http://www.genome.jp/dbget-bin/www_bget?ko:K15278 Q9W429 876 1.6e-92 UDP-xylose and UDP-N-acetylglucosamine transporter OS=Drosophila melanogaster GN=Efr PE=2 SV=1 PF08449//PF03165//PF00892 UAA transporter family//MH1 domain//EamA-like transporter family GO:0055085//GO:0008643//GO:0015780//GO:0006355 transmembrane transport//carbohydrate transport//nucleotide-sugar transport//regulation of transcription, DNA-templated GO:0005338 nucleotide-sugar transmembrane transporter activity GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular KOG1583 UDP-N-acetylglucosamine transporter Cluster-8309.20496 BP_3 376.75 9.72 2159 642938537 XP_008199832.1 1174 1.0e-125 PREDICTED: UDP-xylose and UDP-N-acetylglucosamine transporter [Tribolium castaneum]>gi|270015580|gb|EFA12028.1| hypothetical protein TcasGA2_TC001443 [Tribolium castaneum] -- -- -- -- -- K15278 SLC35B4, YEA4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 http://www.genome.jp/dbget-bin/www_bget?ko:K15278 Q9W429 939 7.5e-100 UDP-xylose and UDP-N-acetylglucosamine transporter OS=Drosophila melanogaster GN=Efr PE=2 SV=1 PF03165//PF08449//PF00892 MH1 domain//UAA transporter family//EamA-like transporter family GO:0008643//GO:0015780//GO:0006355//GO:0055085 carbohydrate transport//nucleotide-sugar transport//regulation of transcription, DNA-templated//transmembrane transport GO:0005338 nucleotide-sugar transmembrane transporter activity GO:0016020//GO:0005622//GO:0016021 membrane//intracellular//integral component of membrane KOG1583 UDP-N-acetylglucosamine transporter Cluster-8309.20497 BP_3 36.42 0.90 2252 642938537 XP_008199832.1 1132 8.0e-121 PREDICTED: UDP-xylose and UDP-N-acetylglucosamine transporter [Tribolium castaneum]>gi|270015580|gb|EFA12028.1| hypothetical protein TcasGA2_TC001443 [Tribolium castaneum] -- -- -- -- -- K15278 SLC35B4, YEA4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 http://www.genome.jp/dbget-bin/www_bget?ko:K15278 Q9W429 890 3.8e-94 UDP-xylose and UDP-N-acetylglucosamine transporter OS=Drosophila melanogaster GN=Efr PE=2 SV=1 PF00892//PF08449//PF03165 EamA-like transporter family//UAA transporter family//MH1 domain GO:0071702//GO:0006355//GO:0044765//GO:0055085 organic substance transport//regulation of transcription, DNA-templated//single-organism transport//transmembrane transport -- -- GO:0016021//GO:0005622//GO:0016020 integral component of membrane//intracellular//membrane KOG1583 UDP-N-acetylglucosamine transporter Cluster-8309.20499 BP_3 147.35 4.72 1797 642921155 XP_975421.2 1483 1.3e-161 PREDICTED: nitrilase and fragile histidine triad fusion protein NitFhit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76464 1092 1.1e-117 Nitrilase and fragile histidine triad fusion protein NitFhit OS=Drosophila melanogaster GN=NitFhit PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0807 Carbon-nitrogen hydrolase Cluster-8309.20503 BP_3 29.17 0.44 3463 189235122 XP_001811652.1 2859 0.0e+00 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 412 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1558 2.0e-171 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF05602//PF01496//PF00856//PF05132 Cleft lip and palate transmembrane protein 1 (CLPTM1)//V-type ATPase 116kDa subunit family//SET domain//RNA polymerase III RPC4 GO:0006206//GO:0006383//GO:0006351//GO:0006144//GO:0015991//GO:0015992 pyrimidine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//purine nucleobase metabolic process//ATP hydrolysis coupled proton transport//proton transport GO:0003677//GO:0005515//GO:0015078//GO:0003682//GO:0003899 DNA binding//protein binding//hydrogen ion transmembrane transporter activity//chromatin binding//DNA-directed RNA polymerase activity GO:0033179//GO:0000785//GO:0005730//GO:0005666//GO:0016021 proton-transporting V-type ATPase, V0 domain//chromatin//nucleolus//DNA-directed RNA polymerase III complex//integral component of membrane KOG1079 Transcriptional repressor EZH1 Cluster-8309.20506 BP_3 22.46 0.69 1867 478256535 ENN76719.1 605 8.5e-60 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q14588 355 3.4e-32 Zinc finger protein 234 OS=Homo sapiens GN=ZNF234 PE=2 SV=3 PF13912//PF04810//PF16622//PF00096//PF13465//PF01283//PF00130 C2H2-type zinc finger//Sec23/Sec24 zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain//Ribosomal protein S26e//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0042254//GO:0006412//GO:0006888//GO:0006886 intracellular signal transduction//ribosome biogenesis//translation//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003735//GO:0008270//GO:0046872 structural constituent of ribosome//zinc ion binding//metal ion binding GO:0005840//GO:0005622//GO:0030127 ribosome//intracellular//COPII vesicle coat -- -- Cluster-8309.20509 BP_3 167.00 18.93 717 642922973 XP_008200475.1 212 1.2e-14 PREDICTED: RNMT-activating mini protein-like [Tribolium castaneum]>gi|270006584|gb|EFA03032.1| hypothetical protein TcasGA2_TC010457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05656//PF15320 Protein of unknown function (DUF805)//mRNA cap methylation, RNMT-activating mini protein GO:0032259 methylation GO:0003723 RNA binding GO:0005845//GO:0016021 mRNA cap binding complex//integral component of membrane -- -- Cluster-8309.20510 BP_3 2.00 1.23 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20517 BP_3 180.01 12.43 990 91091696 XP_972659.1 620 8.2e-62 PREDICTED: nogo-B receptor [Tribolium castaneum]>gi|270001062|gb|EEZ97509.1| hypothetical protein TcasGA2_TC011353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99LJ8 268 2.2e-22 Dehydrodolichyl diphosphate syntase complex subunit Nus1 OS=Mus musculus GN=Nus1 PE=2 SV=1 PF01255 Putative undecaprenyl diphosphate synthase -- -- GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups -- -- KOG2818 Predicted undecaprenyl diphosphate synthase Cluster-8309.20521 BP_3 68.36 0.52 6646 642922382 XP_008193134.1 7387 0.0e+00 PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|270007200|gb|EFA03648.1| hypothetical protein TcasGA2_TC013742 [Tribolium castaneum] 642922381 XM_008194912.1 96 1.30307e-39 PREDICTED: Tribolium castaneum myosin 7B (LOC662874), mRNA K10359 MYO7 myosin VII http://www.genome.jp/dbget-bin/www_bget?ko:K10359 Q29P71 5404 0.0e+00 Myosin-VIIa OS=Drosophila pseudoobscura pseudoobscura GN=ck PE=3 SV=1 PF00612//PF00784//PF00063 IQ calmodulin-binding motif//MyTH4 domain//Myosin head (motor domain) -- -- GO:0005515//GO:0003774//GO:0005524 protein binding//motor activity//ATP binding GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.20523 BP_3 155.00 5.48 1654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20524 BP_3 10.41 0.76 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20525 BP_3 416.34 7.81 2862 642921203 XP_008192760.1 1329 1.5e-143 PREDICTED: uncharacterized protein LOC103312841 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 P82798 286 5.2e-24 Transcriptional regulator ATRX (Fragment) OS=Macropus eugenii GN=ATRX PE=2 SV=1 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.20526 BP_3 9.00 2.43 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20528 BP_3 6.00 0.46 915 -- -- -- -- -- 525346494 KC793965.1 196 4.47222e-96 Scylla paramamosain clone Scpa73 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2053 BP_3 10.00 4.14 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20530 BP_3 57.96 1.42 2258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20531 BP_3 5.41 1.26 499 642940435 XP_008194234.1 498 5.8e-48 PREDICTED: rho GTPase-activating protein 26, partial [Tribolium castaneum] -- -- -- -- -- K13736 ARHGAP10 Rho GTPase-activating protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13736 Q5U4T3 283 2.0e-24 Rho GTPase-activating protein 26 OS=Xenopus laevis GN=arhgap26 PE=2 SV=1 PF12361//PF00620 Duffy-antigen binding protein//RhoGAP domain GO:0007165 signal transduction -- -- GO:0016020 membrane KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins Cluster-8309.20535 BP_3 89.00 7.01 904 546675036 ERL86297.1 794 5.0e-82 hypothetical protein D910_03705 [Dendroctonus ponderosae] -- -- -- -- -- K02879 RP-L17, MRPL17, rplQ large subunit ribosomal protein L17 http://www.genome.jp/dbget-bin/www_bget?ko:K02879 Q9D8P4 301 3.0e-26 39S ribosomal protein L17, mitochondrial OS=Mus musculus GN=Mrpl17 PE=1 SV=1 PF01196 Ribosomal protein L17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3280 Mitochondrial/chloroplast ribosomal protein L17 Cluster-8309.20537 BP_3 130.12 1.00 6583 546680884 ERL91070.1 2441 3.8e-272 hypothetical protein D910_08412 [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 Q9NSI6 1506 4.1e-165 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens GN=BRWD1 PE=1 SV=4 PF06507//PF00439//PF02798//PF13417//PF10717//PF00400//PF13409 Auxin response factor//Bromodomain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Occlusion-derived virus envelope protein ODV-E18//WD domain, G-beta repeat//Glutathione S-transferase, N-terminal domain GO:0006355//GO:0009725 regulation of transcription, DNA-templated//response to hormone GO:0005515//GO:0003677 protein binding//DNA binding GO:0019031//GO:0005634 viral envelope//nucleus KOG0644 Uncharacterized conserved protein, contains WD40 repeat and BROMO domains Cluster-8309.20540 BP_3 77.00 3.66 1306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20541 BP_3 162.00 6.46 1501 270004929 EFA01377.1 1424 7.4e-155 hypothetical protein TcasGA2_TC030877 [Tribolium castaneum] -- -- -- -- -- K06827 CTGF connective tissue growth factor http://www.genome.jp/dbget-bin/www_bget?ko:K06827 O54775 456 5.3e-44 WNT1-inducible-signaling pathway protein 1 OS=Mus musculus GN=Wisp1 PE=2 SV=1 PF00093//PF00219 von Willebrand factor type C domain//Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520//GO:0005515 insulin-like growth factor binding//protein binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-8309.20543 BP_3 102.44 1.15 4577 641658103 XP_008180598.1 728 1.1e-73 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 668 4.3e-68 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF07776//PF13912//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.20545 BP_3 68.23 0.61 5679 642914389 XP_008201657.1 304 2.1e-24 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 257 2.4e-20 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.20546 BP_3 55.39 0.51 5526 642914389 XP_008201657.1 245 1.4e-17 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 195 3.6e-13 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20549 BP_3 135.69 3.45 2187 642933809 XP_008197363.1 1019 9.8e-108 PREDICTED: G-protein coupled receptor 143 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51810 280 2.0e-23 G-protein coupled receptor 143 OS=Homo sapiens GN=GPR143 PE=1 SV=2 PF00002//PF01534//PF02101 7 transmembrane receptor (Secretin family)//Frizzled/Smoothened family membrane region//Ocular albinism type 1 protein GO:0007186//GO:0007166 G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.20550 BP_3 1.00 8.09 249 780089478 XP_011673857.1 203 4.6e-14 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q4UMH6 172 7.5e-12 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF04857//PF00023//PF13606 CAF1 family ribonuclease//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.20551 BP_3 1.00 2.52 287 123494860 XP_001326609.1 235 1.0e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 179 1.3e-12 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.20552 BP_3 3.00 3.19 328 123494860 XP_001326609.1 216 1.9e-15 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- P17221 156 7.1e-10 Sex-determining protein fem-1 OS=Caenorhabditis elegans GN=fem-1 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20557 BP_3 73.69 0.69 5455 546679855 ERL90243.1 1124 1.6e-119 hypothetical protein D910_07596 [Dendroctonus ponderosae] -- -- -- -- -- K18019 PTPN7 tyrosine-protein phosphatase non-receptor type 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18019 P54829 259 1.4e-20 Tyrosine-protein phosphatase non-receptor type 5 OS=Homo sapiens GN=PTPN5 PE=1 SV=4 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.20559 BP_3 83.76 0.89 4818 91091178 XP_971714.1 1911 8.0e-211 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] 564254995 XM_006266415.1 37 5.9224e-07 PREDICTED: Alligator mississippiensis F-box protein 21 (FBXO21), mRNA K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q9EPL9 1217 9.8e-132 Peroxisomal acyl-coenzyme A oxidase 3 OS=Mus musculus GN=Acox3 PE=1 SV=2 PF00646//PF08755//PF01756//PF12937//PF00441//PF02770 F-box domain//Hemimethylated DNA-binding protein YccV like//Acyl-CoA oxidase//F-box-like//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0006635//GO:0006637//GO:0055114//GO:0006631//GO:0006118 fatty acid beta-oxidation//acyl-CoA metabolic process//oxidation-reduction process//fatty acid metabolic process//obsolete electron transport GO:0005515//GO:0003677//GO:0003995//GO:0016627//GO:0003997 protein binding//DNA binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.20562 BP_3 9.00 0.66 948 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.20563 BP_3 5.00 6.24 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.20566 BP_3 29.00 0.47 3279 -- -- -- -- -- 46064034 AC034285.6 76 8.39179e-29 Mus musculus chromosome 13, clone RP23-220G21, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20568 BP_3 36.68 11.50 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20570 BP_3 77.70 3.95 1239 91089019 XP_968547.1 310 9.1e-26 PREDICTED: mitogen-activated protein kinase kinase kinase 7 [Tribolium castaneum]>gi|270012716|gb|EFA09164.1| TGF-beta activated kinase 1 [Tribolium castaneum] -- -- -- -- -- K04427 MAP3K7, TAK1 mitogen-activated protein kinase kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04427 P0C8E4 142 1.1e-07 Mitogen-activated protein kinase kinase kinase 7 OS=Rattus norvegicus GN=Map3k7 PE=2 SV=1 -- -- GO:0016310 phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.20571 BP_3 74.00 0.54 6882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20573 BP_3 6.51 0.81 678 642925139 XP_001813550.2 274 7.4e-22 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF13912//PF13465//PF00096//PF15750 BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Ubiquitin-binding zinc-finger -- -- GO:0046872//GO:0043130//GO:0003677 metal ion binding//ubiquitin binding//DNA binding -- -- -- -- Cluster-8309.20575 BP_3 48.16 0.86 2983 642925139 XP_001813550.2 446 3.7e-41 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42282 287 4.2e-24 Protein tramtrack, alpha isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=3 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20578 BP_3 44.79 0.77 3086 642910499 XP_008200240.1 654 2.9e-65 PREDICTED: G protein alpha i subunit [Tribolium castaneum]>gi|270014387|gb|EFA10835.1| hypothetical protein TcasGA2_TC001612 [Tribolium castaneum] 766921600 XM_011507026.1 75 2.8386e-28 PREDICTED: Ceratosolen solmsi marchali guanine nucleotide-binding protein G(i) subunit alpha-like (LOC105368111), mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 P41776 616 3.1e-62 Guanine nucleotide-binding protein G(i) subunit alpha OS=Homarus americanus PE=2 SV=2 PF00503 G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0005525//GO:0004871//GO:0019001//GO:0031683 GTPase activity//GTP binding//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.20579 BP_3 38.08 0.33 5917 642924790 XP_008194041.1 2691 3.5e-301 PREDICTED: period isoform X2 [Tribolium castaneum]>gi|270008118|gb|EFA04566.1| period [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 Q25637 1529 8.0e-168 Period circadian protein OS=Periplaneta americana GN=per PE=2 SV=2 PF08447//PF00516//PF08926//PF01554//PF00989 PAS fold//Envelope glycoprotein GP120//Domain of unknown function (DUF1908)//MatE//PAS fold GO:0015893//GO:0050794//GO:0016310//GO:0006855//GO:0006355//GO:0055085//GO:0006810//GO:0009069//GO:0006468 drug transport//regulation of cellular process//phosphorylation//drug transmembrane transport//regulation of transcription, DNA-templated//transmembrane transport//transport//serine family amino acid metabolic process//protein phosphorylation GO:0000287//GO:0015297//GO:0005515//GO:0004674//GO:0005524//GO:0015238 magnesium ion binding//antiporter activity//protein binding//protein serine/threonine kinase activity//ATP binding//drug transmembrane transporter activity GO:0016020//GO:0019031 membrane//viral envelope KOG3753 Circadian clock protein period Cluster-8309.2058 BP_3 179.52 3.08 3102 642934903 XP_008197856.1 2510 1.8e-280 PREDICTED: WD repeat and HMG-box DNA-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K11274 WDHD1, CTF4 chromosome transmission fidelity protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11274 O75717 1036 6.1e-111 WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens GN=WDHD1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1274 WD40 repeat protein Cluster-8309.20581 BP_3 12.84 0.53 1467 642920269 XP_008192276.1 164 9.2e-09 PREDICTED: anoctamin-1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity -- -- -- -- Cluster-8309.20584 BP_3 239.16 7.08 1921 270009743 EFA06191.1 1602 2.2e-175 hypothetical protein TcasGA2_TC009040 [Tribolium castaneum] 805761554 XM_012298644.1 131 1.30093e-59 PREDICTED: Megachile rotundata CCA tRNA nucleotidyltransferase 1, mitochondrial (LOC100882545), transcript variant X2, mRNA K00974 cca tRNA nucleotidyltransferase (CCA-adding enzyme) http://www.genome.jp/dbget-bin/www_bget?ko:K00974 Q96Q11 1074 1.5e-115 CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=TRNT1 PE=1 SV=2 PF01743 Poly A polymerase head domain GO:0006396 RNA processing GO:0003723//GO:0016779 RNA binding//nucleotidyltransferase activity -- -- KOG2159 tRNA nucleotidyltransferase/poly(A) polymerase Cluster-8309.20585 BP_3 28.64 0.78 2059 642918767 XP_008191575.1 602 2.1e-59 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9Y251 452 2.1e-43 Heparanase OS=Homo sapiens GN=HPSE PE=1 SV=2 PF15785//PF03662 Serine/threonine-protein kinase smg-1//Glycosyl hydrolase family 79, N-terminal domain GO:0009069//GO:0016310//GO:0000184 serine family amino acid metabolic process//phosphorylation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0016798//GO:0004674 hydrolase activity, acting on glycosyl bonds//protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.20586 BP_3 2.00 0.35 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20587 BP_3 1.00 19.14 227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20588 BP_3 110.22 0.68 8086 642930915 XP_008196139.1 1612 6.3e-176 PREDICTED: limulus clotting factor C-like isoform X2 [Tribolium castaneum]>gi|270012763|gb|EFA09211.1| serine protease P69 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 506 4.6e-49 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.20590 BP_3 297.85 9.83 1752 91089285 XP_970985.1 1201 6.2e-129 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 [Tribolium castaneum]>gi|270011448|gb|EFA07896.1| hypothetical protein TcasGA2_TC005471 [Tribolium castaneum] 572257887 XM_006607277.1 135 7.07774e-62 PREDICTED: Apis dorsata cytoplasmic phosphatidylinositol transfer protein 1-like (LOC102673968), mRNA -- -- -- -- Q9U9P7 1028 2.9e-110 Cytoplasmic phosphatidylinositol transfer protein 1 OS=Drosophila melanogaster GN=rdgBbeta PE=2 SV=1 PF02121 Phosphatidylinositol transfer protein GO:0006810 transport -- -- GO:0005622 intracellular KOG3668 Phosphatidylinositol transfer protein Cluster-8309.20594 BP_3 361.05 2.90 6298 91094947 XP_968721.1 2301 6.2e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF16752//PF02295//PF15460//PF06815 Tubulin-specific chaperone C N-terminal domain//Adenosine deaminase z-alpha domain//Something about silencing, SAS, complex subunit 4//Reverse transcriptase connection domain GO:0006278//GO:0016573//GO:0006807 RNA-dependent DNA replication//histone acetylation//nitrogen compound metabolic process GO:0015631//GO:0003723//GO:0003964//GO:0003726 tubulin binding//RNA binding//RNA-directed DNA polymerase activity//double-stranded RNA adenosine deaminase activity GO:0045298 tubulin complex KOG2432 Uncharacterized conserved protein Cluster-8309.20595 BP_3 108.74 2.75 2195 642916064 XP_970366.3 2023 3.7e-224 PREDICTED: twinkle protein, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17680 PEO1 twinkle protein http://www.genome.jp/dbget-bin/www_bget?ko:K17680 Q96RR1 1141 2.9e-123 Twinkle protein, mitochondrial OS=Homo sapiens GN=PEO1 PE=1 SV=1 PF03193//PF00005//PF06009//PF03796//PF01637//PF00437 Protein of unknown function, DUF258//ABC transporter//Laminin Domain II//DnaB-like helicase C terminal domain//Archaeal ATPase//Type II/IV secretion system protein GO:0006810//GO:0006260//GO:0007155 transport//DNA replication//cell adhesion GO:0005524//GO:0003678//GO:0003924//GO:0016887//GO:0005525 ATP binding//DNA helicase activity//GTPase activity//ATPase activity//GTP binding GO:0005657 replication fork KOG2373 Predicted mitochondrial DNA helicase twinkle Cluster-8309.20597 BP_3 97.67 4.93 1246 91088447 XP_968769.1 946 1.6e-99 PREDICTED: PI-PLC X domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270012211|gb|EFA08659.1| hypothetical protein TcasGA2_TC006324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58EK3 556 1.1e-55 PI-PLC X domain-containing protein 3 OS=Danio rerio GN=plcxd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4306 Glycosylphosphatidylinositol-specific phospholipase C Cluster-8309.206 BP_3 10.00 0.40 1509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2060 BP_3 37.20 0.60 3273 478262642 ENN81206.1 633 8.5e-63 hypothetical protein YQE_02396, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V7Q6 369 1.4e-33 Serine/threonine-protein kinase ULK3 OS=Xenopus laevis GN=ulk3 PE=2 SV=1 PF02740//PF06293//PF00069//PF08502//PF07714//PF03829//PF05445 Colipase, C-terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//LeuA allosteric (dimerisation) domain//Protein tyrosine kinase//PTS system glucitol/sorbitol-specific IIA component//Poxvirus serine/threonine protein kinase GO:0016042//GO:0008643//GO:0006090//GO:0009401//GO:0009099//GO:0009097//GO:0009098//GO:0006468//GO:0007586 lipid catabolic process//carbohydrate transport//pyruvate metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system//valine biosynthetic process//isoleucine biosynthetic process//leucine biosynthetic process//protein phosphorylation//digestion GO:0016773//GO:0008047//GO:0008982//GO:0004672//GO:0003852//GO:0005524 phosphotransferase activity, alcohol group as acceptor//enzyme activator activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase activity//2-isopropylmalate synthase activity//ATP binding GO:0005576//GO:0016020//GO:0009357//GO:0005737 extracellular region//membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//cytoplasm -- -- Cluster-8309.20601 BP_3 111.94 3.26 1946 91088343 XP_971105.1 792 1.8e-81 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 594 6.9e-60 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF08720//PF00106//PF01370//PF02558//PF02826//PF02882//PF12242 Influenza C hemagglutinin stalk//short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0015940//GO:0007165//GO:0009396//GO:0046487//GO:0055114//GO:0008152//GO:0019064 pantothenate biosynthetic process//signal transduction//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//oxidation-reduction process//metabolic process//fusion of virus membrane with host plasma membrane GO:0050662//GO:0004488//GO:0003824//GO:0016491//GO:0051287//GO:0008677//GO:0046789 coenzyme binding//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//oxidoreductase activity//NAD binding//2-dehydropantoate 2-reductase activity//host cell surface receptor binding GO:0019031//GO:0009986 viral envelope//cell surface KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.20602 BP_3 1207.33 24.37 2680 642916504 XP_008191070.1 943 7.8e-99 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum]>gi|270003609|gb|EFA00057.1| hypothetical protein TcasGA2_TC002865 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 283 1.1e-23 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF05192//PF02052//PF00560//PF01484 Leucine rich repeat//MutS domain III//Gallidermin//Leucine Rich Repeat//Nematode cuticle collagen N-terminal domain GO:0006298//GO:0042742 mismatch repair//defense response to bacterium GO:0005524//GO:0030983//GO:0005515//GO:0042302 ATP binding//mismatched DNA binding//protein binding//structural constituent of cuticle GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.20605 BP_3 130.67 2.58 2736 642916504 XP_008191070.1 943 8.0e-99 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum]>gi|270003609|gb|EFA00057.1| hypothetical protein TcasGA2_TC002865 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 283 1.1e-23 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF02052//PF05192//PF13855//PF00001//PF00560//PF01484 Gallidermin//MutS domain III//Leucine rich repeat//7 transmembrane receptor (rhodopsin family)//Leucine Rich Repeat//Nematode cuticle collagen N-terminal domain GO:0042742//GO:0006298//GO:0007186 defense response to bacterium//mismatch repair//G-protein coupled receptor signaling pathway GO:0005515//GO:0042302//GO:0004930//GO:0005524//GO:0030983 protein binding//structural constituent of cuticle//G-protein coupled receptor activity//ATP binding//mismatched DNA binding GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.20609 BP_3 559.00 40.14 963 91083047 XP_966461.1 849 2.2e-88 PREDICTED: gamma-secretase subunit Aph-1 [Tribolium castaneum]>gi|270007655|gb|EFA04103.1| hypothetical protein TcasGA2_TC014338 [Tribolium castaneum] -- -- -- -- -- K06172 APH1 anterior pharynx defective 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06172 Q9VQG2 651 8.4e-67 Gamma-secretase subunit Aph-1 OS=Drosophila melanogaster GN=aph-1 PE=1 SV=1 PF06105 Aph-1 protein GO:0043085//GO:0016485 positive regulation of catalytic activity//protein processing -- -- GO:0016021 integral component of membrane KOG3972 Predicted membrane protein Cluster-8309.20611 BP_3 322.00 10.41 1783 646712116 KDR17021.1 949 1.0e-99 CRAL-TRIO domain-containing protein C3H8.02 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q10138 236 2.0e-18 CRAL-TRIO domain-containing protein C3H8.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3H8.02 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1470 Phosphatidylinositol transfer protein PDR16 and related proteins Cluster-8309.20614 BP_3 588.49 5.58 5377 270014663 EFA11111.1 4795 0.0e+00 hypothetical protein TcasGA2_TC004709 [Tribolium castaneum] -- -- -- -- -- K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 P31696 1106 8.1e-119 Agrin OS=Gallus gallus GN=AGRN PE=1 SV=3 PF00008//PF07648//PF00050 EGF-like domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.20615 BP_3 120.12 2.38 2720 478253744 ENN74040.1 2544 1.8e-284 hypothetical protein YQE_09365, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.20616 BP_3 17.88 0.34 2844 478253744 ENN74040.1 2298 6.3e-256 hypothetical protein YQE_09365, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00036//PF13405//PF13833//PF13499 EF hand//EF-hand domain//EF-hand domain pair//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.20624 BP_3 1.00 0.35 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20627 BP_3 122.08 1.06 5868 642924788 XP_008194040.1 1819 4.5e-200 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 Q25637 990 2.5e-105 Period circadian protein OS=Periplaneta americana GN=per PE=2 SV=2 PF01554//PF00989//PF08447 MatE//PAS fold//PAS fold GO:0006810//GO:0006855//GO:0055085//GO:0015893//GO:0006355 transport//drug transmembrane transport//transmembrane transport//drug transport//regulation of transcription, DNA-templated GO:0015238//GO:0005515//GO:0015297 drug transmembrane transporter activity//protein binding//antiporter activity GO:0016020 membrane KOG3753 Circadian clock protein period Cluster-8309.2063 BP_3 23.00 1.13 1273 665818199 XP_008557915.1 159 3.0e-08 PREDICTED: tigger transposable element-derived protein 4-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20633 BP_3 36.00 1.01 2003 270006188 EFA02636.1 1626 3.7e-178 hypothetical protein TcasGA2_TC008357 [Tribolium castaneum] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 O16098 1328 5.5e-145 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128//PF02284 Alpha amylase, catalytic domain//Cytochrome c oxidase subunit Va GO:0006123//GO:0015992//GO:0005975 mitochondrial electron transport, cytochrome c to oxygen//proton transport//carbohydrate metabolic process GO:0003824//GO:0004129//GO:0043169 catalytic activity//cytochrome-c oxidase activity//cation binding GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane -- -- Cluster-8309.20634 BP_3 8.00 0.64 897 91088445 XP_968690.1 206 7.5e-14 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 184 1.1e-12 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 -- -- GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0000151 ubiquitin ligase complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.20635 BP_3 38.57 1.44 1582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20636 BP_3 2329.07 47.00 2680 759041178 XP_011329400.1 2003 9.5e-222 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Cerapachys biroi] 195434173 XM_002065042.1 152 3.86368e-71 Drosophila willistoni GK15268 (Dwil\GK15268), mRNA K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 1145 1.2e-123 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF02065//PF16499 Melibiase//Alpha galactosidase A GO:0006012//GO:0001575//GO:0046486//GO:0005975 galactose metabolic process//globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0004553//GO:0004557 hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-galactosidase activity -- -- KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.20640 BP_3 230.69 1.54 7518 591350379 XP_007069726.1 691 3.7e-69 PREDICTED: zinc finger protein 850-like [Chelonia mydas] 642917654 XM_008195282.1 761 0 PREDICTED: Tribolium castaneum zinc finger protein 502 (LOC100141877), mRNA -- -- -- -- P28698 639 1.6e-64 Myeloid zinc finger 1 OS=Homo sapiens GN=MZF1 PE=1 SV=3 PF13912//PF16622//PF06350//PF00096//PF13465//PF07975//PF01155 C2H2-type zinc finger//zinc-finger C2H2-type//Hormone-sensitive lipase (HSL) N-terminus//Zinc finger, C2H2 type//Zinc-finger double domain//TFIIH C1-like domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0008203//GO:0006281//GO:0006464//GO:0016042 cholesterol metabolic process//DNA repair//cellular protein modification process//lipid catabolic process GO:0016151//GO:0046872//GO:0016298//GO:0008270 nickel cation binding//metal ion binding//lipase activity//zinc ion binding -- -- -- -- Cluster-8309.20641 BP_3 434.66 46.53 742 478254316 ENN74570.1 316 1.1e-26 hypothetical protein YQE_08892, partial [Dendroctonus ponderosae]>gi|546674045|gb|ERL85533.1| hypothetical protein D910_02952 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20642 BP_3 2.00 1.08 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20649 BP_3 45.73 0.68 3520 642911313 XP_008199366.1 1106 1.3e-117 PREDICTED: ubiquitin carboxyl-terminal hydrolase 8-like isoform X1 [Tribolium castaneum]>gi|270014853|gb|EFA11301.1| hypothetical protein TcasGA2_TC010838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O57429 296 4.5e-25 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF04805//PF00443 E10-like protein conserved region//Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0055114 protein deubiquitination//oxidation-reduction process GO:0016972//GO:0036459 thiol oxidase activity//ubiquitinyl hydrolase activity -- -- KOG1868 Ubiquitin C-terminal hydrolase Cluster-8309.20653 BP_3 7.00 1.46 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20657 BP_3 4.00 1.74 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20669 BP_3 165.00 2.19 3925 270003759 EFA00207.1 1160 7.9e-124 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.68205e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.20670 BP_3 38.25 0.32 6126 642923511 XP_008193539.1 913 5.4e-95 PREDICTED: pH-response transcription factor pacC/RIM101-like isoform X1 [Tribolium castaneum]>gi|270006994|gb|EFA03442.1| hypothetical protein TcasGA2_TC013432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14872 643 4.5e-65 Metal regulatory transcription factor 1 OS=Homo sapiens GN=MTF1 PE=1 SV=2 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.20671 BP_3 257.42 2.19 5959 642923511 XP_008193539.1 1818 6.0e-200 PREDICTED: pH-response transcription factor pacC/RIM101-like isoform X1 [Tribolium castaneum]>gi|270006994|gb|EFA03442.1| hypothetical protein TcasGA2_TC013432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14872 837 1.4e-87 Metal regulatory transcription factor 1 OS=Homo sapiens GN=MTF1 PE=1 SV=2 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.20673 BP_3 109.31 2.62 2306 189236990 XP_970274.2 792 2.2e-81 PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|642921800|ref|XP_008199324.1| PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|270008114|gb|EFA04562.1| hypothetical protein TcasGA2_TC010947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZS10 145 9.5e-08 C-type lectin domain family 17, member A OS=Homo sapiens GN=CLEC17A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20674 BP_3 318.49 1.72 9204 642911642 XP_008200683.1 12643 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: neurofibromin [Tribolium castaneum] 751776924 XM_011199144.1 429 0 PREDICTED: Bactrocera dorsalis neurofibromin (LOC105221988), mRNA K08052 NF1 neurofibromin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08052 P97526 5995 0.0e+00 Neurofibromin OS=Rattus norvegicus GN=Nf1 PE=1 SV=1 PF09090//PF00616//PF12356 MIF4G like//GTPase-activator protein for Ras-like GTPase//Protein of unknown function (DUF3643) GO:0016070//GO:0006915//GO:0032465//GO:0016567//GO:0043087 RNA metabolic process//apoptotic process//regulation of cytokinesis//protein ubiquitination//regulation of GTPase activity GO:0004842 ubiquitin-protein transferase activity -- -- KOG1826 Ras GTPase activating protein RasGAP/neurofibromin Cluster-8309.20684 BP_3 104.79 0.86 6147 642918693 XP_008191540.1 2619 8.2e-293 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 1276 1.8e-138 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200//PF00788 Keratinocyte differentiation-associated//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.20686 BP_3 19.00 0.58 1860 270005301 EFA01749.1 402 2.9e-36 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20689 BP_3 57.00 2.50 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20690 BP_3 262.21 6.21 2328 91079360 XP_970234.1 2690 1.8e-301 PREDICTED: armadillo repeat-containing protein 8 [Tribolium castaneum]>gi|270004363|gb|EFA00811.1| hypothetical protein TcasGA2_TC003698 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBR3 1449 5.9e-159 Armadillo repeat-containing protein 8 OS=Mus musculus GN=Armc8 PE=2 SV=2 PF04869//PF02985//PF11698//PF00514 Uso1 / p115 like vesicle tethering protein, head region//HEAT repeat//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0015991//GO:0006886//GO:0048280 ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle fusion with Golgi apparatus GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221//GO:0000139//GO:0005737 vacuolar proton-transporting V-type ATPase, V1 domain//Golgi membrane//cytoplasm -- -- Cluster-8309.20691 BP_3 10.23 0.32 1853 91079360 XP_970234.1 1355 9.1e-147 PREDICTED: armadillo repeat-containing protein 8 [Tribolium castaneum]>gi|270004363|gb|EFA00811.1| hypothetical protein TcasGA2_TC003698 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBR3 548 1.4e-54 Armadillo repeat-containing protein 8 OS=Mus musculus GN=Armc8 PE=2 SV=2 PF00514//PF04869//PF02985 Armadillo/beta-catenin-like repeat//Uso1 / p115 like vesicle tethering protein, head region//HEAT repeat GO:0048280//GO:0006886 vesicle fusion with Golgi apparatus//intracellular protein transport GO:0005515 protein binding GO:0005737//GO:0000139 cytoplasm//Golgi membrane -- -- Cluster-8309.20694 BP_3 60.95 1.78 1944 642920143 XP_008192222.1 2144 3.1e-238 PREDICTED: arylsulfatase B [Tribolium castaneum]>gi|270005303|gb|EFA01751.1| hypothetical protein TcasGA2_TC007349 [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 Q5FYB0 906 4.6e-96 Arylsulfatase J OS=Homo sapiens GN=ARSJ PE=2 SV=1 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.20699 BP_3 11.65 0.55 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2070 BP_3 325.00 25.59 904 268370273 NP_001161309.1 480 1.3e-45 osiris-like protein precursor [Tribolium castaneum]>gi|270013103|gb|EFA09551.1| hypothetical protein TcasGA2_TC011661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20701 BP_3 11.73 0.83 974 642914271 XP_008201616.1 451 3.2e-42 PREDICTED: sulfiredoxin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12260 SRX1 sulfiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K12260 Q9D975 333 6.3e-30 Sulfiredoxin-1 OS=Mus musculus GN=Srxn1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3388 Predicted transcription regulator/nuclease, contains ParB domain Cluster-8309.20702 BP_3 21.00 0.53 2205 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20705 BP_3 63.00 1.25 2724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20706 BP_3 912.62 33.24 1615 642924852 XP_008194066.1 1218 6.1e-131 PREDICTED: nuclear migration protein nudC [Tribolium castaneum] 642924851 XM_008195844.1 207 6.15463e-102 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- O35685 811 3.9e-85 Nuclear migration protein nudC OS=Mus musculus GN=Nudc PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.20709 BP_3 529.06 11.69 2473 189238821 XP_968538.2 947 2.5e-99 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|642927448|ref|XP_008195277.1| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|270010156|gb|EFA06604.1| hypothetical protein TcasGA2_TC009519 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 455 1.1e-43 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF13184//PF13014//PF00013//PF07650 NusA-like KH domain//KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.20710 BP_3 39.24 0.62 3345 189239641 XP_972129.2 1708 1.9e-187 PREDICTED: fukutin-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CG64 917 4.2e-97 Fukutin-related protein OS=Mus musculus GN=Fkrp PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20711 BP_3 77.20 16.73 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20713 BP_3 2.00 0.83 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0006118//GO:0055114//GO:0006570 obsolete electron transport//oxidation-reduction process//tyrosine metabolic process GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.20715 BP_3 191.00 7.58 1506 642934687 XP_008197771.1 391 4.5e-35 PREDICTED: uncharacterized protein C6orf203 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQF4 170 7.8e-11 Uncharacterized protein C6orf203 homolog OS=Mus musculus PE=1 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.20717 BP_3 89.00 1.20 3855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20718 BP_3 18.14 0.31 3121 546680883 ERL91069.1 1013 7.0e-107 hypothetical protein D910_08411 [Dendroctonus ponderosae] -- -- -- -- -- K14458 MOGAT1, MGAT1 2-acylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14458 Q70VZ7 706 1.1e-72 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF02411//PF03982 MerT mercuric transport protein//Diacylglycerol acyltransferase GO:0015694 mercury ion transport GO:0016747//GO:0015097 transferase activity, transferring acyl groups other than amino-acyl groups//mercury ion transmembrane transporter activity GO:0016020 membrane KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.20719 BP_3 81.28 2.02 2234 332375078 AEE62680.1 845 1.5e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14458 MOGAT1, MGAT1 2-acylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14458 Q70VZ7 597 3.5e-60 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.2072 BP_3 2.00 0.32 593 607365179 EZA59380.1 266 5.5e-21 hypothetical protein X777_00501 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20722 BP_3 1.00 7.27 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20724 BP_3 2.00 4.91 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20727 BP_3 465.00 19.66 1432 478260798 ENN80458.1 1324 2.8e-143 hypothetical protein YQE_03115, partial [Dendroctonus ponderosae]>gi|546673402|gb|ERL85014.1| hypothetical protein D910_02437 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O95801 578 3.6e-58 Tetratricopeptide repeat protein 4 OS=Homo sapiens GN=TTC4 PE=1 SV=3 PF00515//PF13374//PF13181//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG0551 Hsp90 co-chaperone CNS1 (contains TPR repeats) Cluster-8309.20731 BP_3 1.00 3.03 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20737 BP_3 28.95 0.56 2771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03798//PF03470 TLC domain//XS zinc finger domain GO:0031047 gene silencing by RNA -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20738 BP_3 10.00 0.65 1038 546676115 ERL87182.1 192 3.7e-12 hypothetical protein D910_04582 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2074 BP_3 8.00 0.48 1096 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20744 BP_3 9.22 1.28 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20749 BP_3 197.32 5.76 1943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2075 BP_3 3.00 0.37 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20750 BP_3 364.00 11.73 1787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08273 Zinc-binding domain of primase-helicase GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896//GO:0008270//GO:0004386 DNA primase activity//zinc ion binding//helicase activity GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.20752 BP_3 8.60 0.64 938 91081297 XP_968817.1 496 1.9e-47 PREDICTED: protein cornichon homolog 4 [Tribolium castaneum] 755947428 XM_011302162.1 58 2.37407e-19 PREDICTED: Fopius arisanus protein cornichon homolog 4 (LOC105264936), mRNA -- -- -- -- Q3T126 337 2.1e-30 Protein cornichon homolog 4 OS=Bos taurus GN=CNIH4 PE=2 SV=1 PF03311 Cornichon protein GO:0035556 intracellular signal transduction -- -- GO:0016020 membrane KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.20758 BP_3 36.42 0.39 4819 91092828 XP_968011.1 3560 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 4 [Tribolium castaneum]>gi|270004790|gb|EFA01238.1| gluon [Tribolium castaneum] -- -- -- -- -- K06675 SMC4 structural maintenance of chromosome 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06675 P50532 2558 3.1e-287 Structural maintenance of chromosomes protein 4 OS=Xenopus laevis GN=smc4 PE=1 SV=1 PF06160//PF06470//PF02050//PF16519//PF16331//PF06009//PF13304//PF04632//PF13851 Septation ring formation regulator, EzrA//SMC proteins Flexible Hinge Domain//Flagellar FliJ protein//Tetramerisation domain of TRPM//TolA binding protein trimerisation//Laminin Domain II//AAA domain, putative AbiEii toxin, Type IV TA system//Fusaric acid resistance protein family//Growth-arrest specific micro-tubule binding GO:0071973//GO:0000921//GO:0048870//GO:0006935//GO:0051276//GO:0006259//GO:0007155//GO:0006810//GO:0070206//GO:0051262 bacterial-type flagellum-dependent cell motility//septin ring assembly//cell motility//chemotaxis//chromosome organization//DNA metabolic process//cell adhesion//transport//protein trimerization//protein tetramerization GO:0005515//GO:0003774//GO:0005524 protein binding//motor activity//ATP binding GO:0005886//GO:0016020//GO:0005694//GO:0005940//GO:0016021//GO:0031514//GO:0009288 plasma membrane//membrane//chromosome//septin ring//integral component of membrane//motile cilium//bacterial-type flagellum KOG0996 Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) Cluster-8309.20760 BP_3 286.14 43.60 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20761 BP_3 17.02 0.47 2052 642926052 XP_970129.2 406 1.1e-36 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41034 149 2.9e-08 Alpha-tocopherol transfer protein OS=Rattus norvegicus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20763 BP_3 113.37 7.51 1019 91092754 XP_973448.1 653 1.3e-65 PREDICTED: Werner Syndrome-like exonuclease [Tribolium castaneum]>gi|270014889|gb|EFA11337.1| hypothetical protein TcasGA2_TC010877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4PLB3 482 3.5e-47 Werner Syndrome-like exonuclease OS=Drosophila yakuba GN=WRNexo PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding -- -- KOG4373 Predicted 3'-5' exonuclease Cluster-8309.20768 BP_3 1972.07 11.55 8520 478256070 ENN76269.1 1358 1.9e-146 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 268 1.9e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF06220//PF06657//PF00769//PF01025//PF00866//PF03623//PF05837//PF01008//PF10473//PF04508//PF01576//PF00170//PF16331//PF07851//PF04111 U1 zinc finger//Centrosome microtubule-binding domain of Cep57//Ezrin/radixin/moesin family//GrpE//Ring hydroxylating beta subunit//Focal adhesion targeting region//Centromere protein H (CENP-H)//Initiation factor 2 subunit family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Viral A-type inclusion protein repeat//Myosin tail//bZIP transcription factor//TolA binding protein trimerisation//TMPIT-like protein//Autophagy protein Apg6 GO:0006725//GO:0007172//GO:0016032//GO:0055114//GO:0044237//GO:0051382//GO:0006457//GO:0006355//GO:0070206//GO:0006468//GO:0006914//GO:0007165 cellular aromatic compound metabolic process//signal complex assembly//viral process//oxidation-reduction process//cellular metabolic process//kinetochore assembly//protein folding//regulation of transcription, DNA-templated//protein trimerization//protein phosphorylation//autophagy//signal transduction GO:0003774//GO:0008092//GO:0003700//GO:0051087//GO:0008134//GO:0045502//GO:0004871//GO:0008017//GO:0042803//GO:0004713//GO:0003824//GO:0000774//GO:0043565//GO:0008270 motor activity//cytoskeletal protein binding//transcription factor activity, sequence-specific DNA binding//chaperone binding//transcription factor binding//dynein binding//signal transducer activity//microtubule binding//protein homodimerization activity//protein tyrosine kinase activity//catalytic activity//adenyl-nucleotide exchange factor activity//sequence-specific DNA binding//zinc ion binding GO:0000776//GO:0005667//GO:0030286//GO:0045298//GO:0005925//GO:0019898//GO:0005737//GO:0016459//GO:0016021 kinetochore//transcription factor complex//dynein complex//tubulin complex//focal adhesion//extrinsic component of membrane//cytoplasm//myosin complex//integral component of membrane -- -- Cluster-8309.2077 BP_3 10.00 0.62 1066 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20771 BP_3 5.00 7.59 309 795012464 XP_011878243.1 361 2.7e-32 PREDICTED: uncharacterized protein LOC105567743 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00136 DNA polymerase family B -- -- GO:0000166//GO:0003677 nucleotide binding//DNA binding -- -- -- -- Cluster-8309.20772 BP_3 6.05 0.35 1135 546675295 ERL86526.1 196 1.4e-12 hypothetical protein D910_03932 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20773 BP_3 11.22 0.42 1588 478249712 ENN70220.1 1482 1.5e-161 hypothetical protein YQE_13006, partial [Dendroctonus ponderosae] -- -- -- -- -- K03514 PAPD5_7, TRF4 non-canonical poly(A) RNA polymerase PAPD5/7 http://www.genome.jp/dbget-bin/www_bget?ko:K03514 Q68ED3 990 6.8e-106 Non-canonical poly(A) RNA polymerase PAPD5 OS=Mus musculus GN=Papd5 PE=1 SV=2 PF01909 Nucleotidyltransferase domain -- -- GO:0016779 nucleotidyltransferase activity -- -- KOG1906 DNA polymerase sigma Cluster-8309.20774 BP_3 278.73 7.88 1997 478249712 ENN70220.1 1666 8.5e-183 hypothetical protein YQE_13006, partial [Dendroctonus ponderosae] -- -- -- -- -- K03514 PAPD5_7, TRF4 non-canonical poly(A) RNA polymerase PAPD5/7 http://www.genome.jp/dbget-bin/www_bget?ko:K03514 Q68ED3 1086 6.3e-117 Non-canonical poly(A) RNA polymerase PAPD5 OS=Mus musculus GN=Papd5 PE=1 SV=2 PF01909 Nucleotidyltransferase domain -- -- GO:0016779 nucleotidyltransferase activity -- -- KOG1906 DNA polymerase sigma Cluster-8309.20775 BP_3 7.00 0.69 779 780677270 XP_011696721.1 272 1.5e-21 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Wasmannia auropunctata] -- -- -- -- -- K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 255 5.6e-21 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13176//PF13414//PF07721//PF13181//PF13374//PF00515 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.20777 BP_3 56.57 1.01 2978 189238125 XP_001814215.1 3142 0.0e+00 PREDICTED: phagocyte signaling-impaired protein [Tribolium castaneum]>gi|270008817|gb|EFA05265.1| hypothetical protein TcasGA2_TC015420 [Tribolium castaneum] 462295253 APGK01052815.1 38 1.01306e-07 Dendroctonus ponderosae Seq01052825, whole genome shotgun sequence K17973 NAA25, MDM20 N-terminal acetyltransferase B complex non-catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17973 Q17DK2 1553 6.6e-171 Phagocyte signaling-impaired protein OS=Aedes aegypti GN=psidin PE=3 SV=2 PF14863//PF13414 Alkyl sulfatase dimerisation//TPR repeat -- -- GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG2053 Mitochondrial inheritance and actin cytoskeleton organization protein Cluster-8309.20780 BP_3 33.59 2.02 1093 642910247 XP_008198549.1 624 3.1e-62 PREDICTED: protein pygopus isoform X3 [Tribolium castaneum]>gi|270014625|gb|EFA11073.1| hypothetical protein TcasGA2_TC004669 [Tribolium castaneum] 241695262 XM_002412985.1 132 2.03164e-60 Ixodes scapularis pygopus, putative, mRNA -- -- -- -- Q9V9W8 427 9.0e-41 Protein pygopus OS=Drosophila melanogaster GN=pygo PE=1 SV=1 PF17123//PF00628//PF13639 RING-like zinc finger//PHD-finger//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.20781 BP_3 65.69 2.78 1429 91090526 XP_970144.1 430 1.3e-39 PREDICTED: UBX domain-containing protein 1 [Tribolium castaneum]>gi|270013875|gb|EFA10323.1| hypothetical protein TcasGA2_TC012540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GL77 271 1.4e-22 UBX domain-containing protein 1 OS=Xenopus tropicalis GN=ubxn1 PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG2689 Predicted ubiquitin regulatory protein Cluster-8309.20782 BP_3 156.00 15.89 765 189234617 XP_975233.2 454 1.1e-42 PREDICTED: U1 small nuclear ribonucleoprotein C [Tribolium castaneum]>gi|270001649|gb|EEZ98096.1| hypothetical protein TcasGA2_TC000509 [Tribolium castaneum] 768438731 XM_011562662.1 101 2.39703e-43 PREDICTED: Plutella xylostella U1 small nuclear ribonucleoprotein C (LOC105391209), mRNA K11095 SNRPC U1 small nuclear ribonucleoprotein C http://www.genome.jp/dbget-bin/www_bget?ko:K11095 Q16IW3 408 1.0e-38 U1 small nuclear ribonucleoprotein C OS=Aedes aegypti GN=AAEL013527 PE=3 SV=1 PF06220 U1 zinc finger -- -- GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding GO:0005634 nucleus KOG3454 U1 snRNP-specific protein C Cluster-8309.20783 BP_3 93.00 8.91 795 675364664 KFM57566.1 422 6.0e-39 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q53H47 179 3.7e-12 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.20784 BP_3 93.12 0.51 9028 642933755 XP_008191527.1 3106 0.0e+00 PREDICTED: huntingtin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42859 1268 2.2e-137 Huntingtin OS=Mus musculus GN=Htt PE=1 SV=2 PF02985//PF08715 HEAT repeat//Papain like viral protease GO:0006508 proteolysis GO:0008242//GO:0016740//GO:0004197//GO:0005515 omega peptidase activity//transferase activity//cysteine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.20786 BP_3 184.91 8.67 1320 642928238 XP_008195500.1 673 7.8e-68 PREDICTED: uncharacterized protein LOC103313603 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DCX1 129 3.9e-06 MAD2L1-binding protein OS=Mus musculus GN=Mad2l1bp PE=2 SV=2 PF06581 Mad1 and Cdc20-bound-Mad2 binding GO:0007096 regulation of exit from mitosis -- -- GO:0005634 nucleus -- -- Cluster-8309.20788 BP_3 4.99 0.32 1042 91091696 XP_972659.1 387 9.0e-35 PREDICTED: nogo-B receptor [Tribolium castaneum]>gi|270001062|gb|EEZ97509.1| hypothetical protein TcasGA2_TC011353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12063 158 1.3e-09 Dehydrodolichyl diphosphate syntase complex subunit NUS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUS1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20789 BP_3 86.91 5.69 1028 478257312 ENN77472.1 452 2.6e-42 hypothetical protein YQE_06000, partial [Dendroctonus ponderosae]>gi|546679541|gb|ERL89989.1| hypothetical protein D910_07348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0006355//GO:0009271 regulation of transcription, DNA-templated//phage shock -- -- -- -- -- -- Cluster-8309.20790 BP_3 9792.92 140.97 3640 270297184 NP_001161900.1 836 2.7e-86 cuticular protein analogous to peritrophins 1-I precursor [Tribolium castaneum]>gi|268373732|gb|ACZ04319.1| CPAP1-I [Tribolium castaneum]>gi|270014341|gb|EFA10789.1| hypothetical protein TcasGA2_TC012766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.20791 BP_3 3.97 0.43 737 642923988 XP_008193959.1 523 1.1e-50 PREDICTED: collagen alpha-3(IX) chain-like [Tribolium castaneum] -- -- -- -- -- K08131 COL9A collagen, type IX, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08131 P20849 278 1.1e-23 Collagen alpha-1(IX) chain OS=Homo sapiens GN=COL9A1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20793 BP_3 214.38 1.48 7285 270016811 EFA13257.1 202 1.8e-12 hypothetical protein TcasGA2_TC001527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20794 BP_3 20.28 0.31 3461 642910641 XP_008200040.1 1434 1.2e-155 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 253 3.5794e-127 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q0P4Q4 716 8.7e-74 FERM domain-containing protein 3 OS=Xenopus tropicalis GN=frmd3 PE=2 SV=2 -- -- -- -- GO:0008092 cytoskeletal protein binding GO:0005737//GO:0005856//GO:0019898 cytoplasm//cytoskeleton//extrinsic component of membrane KOG3530 FERM domain protein EHM2 Cluster-8309.20796 BP_3 138.92 2.01 3615 642926822 XP_008195028.1 2075 5.8e-230 PREDICTED: pre-mRNA-processing factor 40 homolog A [Tribolium castaneum]>gi|270009175|gb|EFA05623.1| hypothetical protein TcasGA2_TC015831 [Tribolium castaneum] 642926821 XM_008196806.1 279 1.31702e-141 PREDICTED: Tribolium castaneum pre-mRNA-processing factor 40 homolog A (LOC658510), mRNA K12821 PRPF40, PRP40 pre-mRNA-processing factor 40 http://www.genome.jp/dbget-bin/www_bget?ko:K12821 Q6NWY9 1215 1.3e-131 Pre-mRNA-processing factor 40 homolog B OS=Homo sapiens GN=PRPF40B PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0152 Spliceosomal protein FBP11/Splicing factor PRP40 Cluster-8309.20797 BP_3 5.00 0.46 815 270016091 EFA12539.1 284 6.2e-23 hypothetical protein TcasGA2_TC016064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9IDV9 130 1.8e-06 Gag-Pol polyprotein OS=Human immunodeficiency virus type 1 group N (isolate YBF106) GN=gag-pol PE=1 SV=3 PF00098 Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.20798 BP_3 24.26 1.41 1119 642936810 XP_008199625.1 426 2.9e-39 PREDICTED: uncharacterized protein LOC103314713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03615//PF00589 GCM motif protein//Phage integrase family GO:0006310//GO:0006355//GO:0015074 DNA recombination//regulation of transcription, DNA-templated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.20802 BP_3 234.61 7.59 1781 642937581 XP_008199107.1 1199 1.1e-128 PREDICTED: zinc finger and BTB domain-containing protein 12-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B87 360 8.6e-33 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20803 BP_3 5.00 1.15 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20804 BP_3 5.00 2.43 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20805 BP_3 44.45 1.29 1957 478260139 ENN79924.1 158 6.1e-08 hypothetical protein YQE_03743, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20807 BP_3 3.94 2.03 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20808 BP_3 35.00 3.04 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20809 BP_3 6.00 0.37 1076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363//PF08299 FYVE zinc finger//Bacterial dnaA protein helix-turn-helix GO:0006270//GO:0006275 DNA replication initiation//regulation of DNA replication GO:0046872//GO:0043565//GO:0005524 metal ion binding//sequence-specific DNA binding//ATP binding -- -- -- -- Cluster-8309.20816 BP_3 146.53 5.06 1687 642910324 XP_008200283.1 1126 3.0e-120 PREDICTED: serologically defined colon cancer antigen 3 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AIW0 245 1.8e-19 Serologically defined colon cancer antigen 3 homolog OS=Mus musculus GN=Sdccag3 PE=2 SV=1 PF04632//PF06156//PF04111//PF06009//PF16867//PF01496 Fusaric acid resistance protein family//Protein of unknown function (DUF972)//Autophagy protein Apg6//Laminin Domain II//Dimethlysulfonioproprionate lyase//V-type ATPase 116kDa subunit family GO:0015992//GO:0007155//GO:0006260//GO:0006914//GO:0015991//GO:0006810 proton transport//cell adhesion//DNA replication//autophagy//ATP hydrolysis coupled proton transport//transport GO:0047869//GO:0015078 dimethylpropiothetin dethiomethylase activity//hydrogen ion transmembrane transporter activity GO:0033179//GO:0005886 proton-transporting V-type ATPase, V0 domain//plasma membrane -- -- Cluster-8309.20817 BP_3 1.00 13.22 236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20818 BP_3 120.33 3.54 1931 642914834 XP_008194983.1 1326 2.2e-143 PREDICTED: inhibitor of growth protein 3 isoform X1 [Tribolium castaneum] 795091176 XM_012024084.1 91 2.25127e-37 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q9NXR8 712 1.4e-73 Inhibitor of growth protein 3 OS=Homo sapiens GN=ING3 PE=1 SV=2 PF00628//PF12090//PF03153//PF00160//PF10280 PHD-finger//Spt20 family//Transcription factor IIA, alpha/beta subunit//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Mediator complex protein GO:0006457//GO:0006357//GO:0006367//GO:0000413 protein folding//regulation of transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//protein peptidyl-prolyl isomerization GO:0001104//GO:0005515//GO:0003712//GO:0003755 RNA polymerase II transcription cofactor activity//protein binding//transcription cofactor activity//peptidyl-prolyl cis-trans isomerase activity GO:0016592//GO:0000124//GO:0005667//GO:0005672 mediator complex//SAGA complex//transcription factor complex//transcription factor TFIIA complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.20819 BP_3 2.00 1.04 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2082 BP_3 5.00 0.42 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20822 BP_3 51.11 3.98 911 642923988 XP_008193959.1 788 2.5e-81 PREDICTED: collagen alpha-3(IX) chain-like [Tribolium castaneum] -- -- -- -- -- K08131 COL9A collagen, type IX, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08131 P20849 400 1.0e-37 Collagen alpha-1(IX) chain OS=Homo sapiens GN=COL9A1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20829 BP_3 390.54 15.92 1474 642938857 XP_008192816.1 843 1.7e-87 PREDICTED: uncharacterized protein LOC659130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20830 BP_3 108.76 4.33 1503 91092412 XP_967539.1 1829 8.0e-202 PREDICTED: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [Tribolium castaneum]>gi|270004747|gb|EFA01195.1| hypothetical protein TcasGA2_TC010522 [Tribolium castaneum] -- -- -- -- -- K05542 DUS1 tRNA-dihydrouridine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05542 Q8C2P3 1090 1.6e-117 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Mus musculus GN=Dus1l PE=2 SV=1 PF00977//PF01207//PF03060//PF04309//PF01680 Histidine biosynthesis protein//Dihydrouridine synthase (Dus)//Nitronate monooxygenase//Glycerol-3-phosphate responsive antiterminator//SOR/SNZ family GO:0002943//GO:0006355//GO:0042823//GO:0009607//GO:0000105//GO:0006807//GO:0055114//GO:0008033//GO:0042819 tRNA dihydrouridine synthesis//regulation of transcription, DNA-templated//pyridoxal phosphate biosynthetic process//response to biotic stimulus//histidine biosynthetic process//nitrogen compound metabolic process//oxidation-reduction process//tRNA processing//vitamin B6 biosynthetic process GO:0018580//GO:0017150//GO:0050660 nitronate monooxygenase activity//tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.20834 BP_3 550.79 6.44 4416 642926793 XP_008195018.1 4263 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 87 8.69992e-35 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2549 3.2e-286 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF01155//PF01068//PF00651//PF00023//PF01363//PF13606 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//ATP dependent DNA ligase domain//BTB/POZ domain//Ankyrin repeat//FYVE zinc finger//Ankyrin repeat GO:0006260//GO:0006310//GO:0006281//GO:0006464 DNA replication//DNA recombination//DNA repair//cellular protein modification process GO:0046872//GO:0003910//GO:0005515//GO:0016151//GO:0005524 metal ion binding//DNA ligase (ATP) activity//protein binding//nickel cation binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.20837 BP_3 31.39 0.74 2329 646691019 KDR07011.1 2331 7.7e-260 WD40 repeat-containing protein SMU1 [Zootermopsis nevadensis] 332372781 BT126569.1 436 0 Dendroctonus ponderosae clone DPO1120_B10 unknown mRNA K13111 SMU1 WD40 repeat-containing protein SMU1 http://www.genome.jp/dbget-bin/www_bget?ko:K13111 Q5ZME8 2188 1.2e-244 WD40 repeat-containing protein SMU1 OS=Gallus gallus GN=SMU1 PE=2 SV=1 PF07569//PF00400 TUP1-like enhancer of split//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0275 Conserved WD40 repeat-containing protein Cluster-8309.20838 BP_3 24.71 2.76 724 478253482 ENN73809.1 617 1.3e-61 hypothetical protein YQE_09587, partial [Dendroctonus ponderosae]>gi|546679134|gb|ERL89639.1| hypothetical protein D910_07004 [Dendroctonus ponderosae] 645007869 XM_001600661.3 119 2.2308e-53 PREDICTED: Nasonia vitripennis adrenodoxin-like protein, mitochondrial (LOC100118135), mRNA -- -- -- -- P37193 558 3.8e-56 Adrenodoxin-like protein, mitochondrial OS=Drosophila melanogaster GN=Fdxh PE=2 SV=3 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0009055//GO:0051536 electron carrier activity//iron-sulfur cluster binding -- -- KOG3309 Ferredoxin Cluster-8309.2084 BP_3 2.00 0.37 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20842 BP_3 64.38 0.77 4303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03391 Nepovirus coat protein, central domain -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.20843 BP_3 622.65 20.21 1777 642935353 XP_008197978.1 397 1.1e-35 PREDICTED: uncharacterized protein LOC103314256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10152//PF05349 Predicted coiled-coil domain-containing protein (DUF2360)//GATA-type transcription activator, N-terminal GO:0045893 positive regulation of transcription, DNA-templated GO:0008270//GO:0003677 zinc ion binding//DNA binding GO:0071203//GO:0005634 WASH complex//nucleus -- -- Cluster-8309.20844 BP_3 23.35 0.83 1641 642935353 XP_008197978.1 267 1.2e-20 PREDICTED: uncharacterized protein LOC103314256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05349//PF10152//PF05529 GATA-type transcription activator, N-terminal//Predicted coiled-coil domain-containing protein (DUF2360)//B-cell receptor-associated protein 31-like GO:0045893//GO:0006886 positive regulation of transcription, DNA-templated//intracellular protein transport GO:0008270//GO:0003677 zinc ion binding//DNA binding GO:0071203//GO:0005634//GO:0016021//GO:0005783 WASH complex//nucleus//integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.20848 BP_3 25.00 0.61 2264 758213866 AJO62246.1 1112 1.7e-118 sensory neuron membrane protein SNMP-2 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- B2RFN2 616 2.3e-62 Sensory neuron membrane protein 2 OS=Heliothis virescens GN=snmp2 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane KOG3776 Plasma membrane glycoprotein CD36 and related membrane receptors Cluster-8309.20849 BP_3 117.40 4.32 1603 332372766 AEE61525.1 557 2.7e-54 unknown [Dendroctonus ponderosae]>gi|478255682|gb|ENN75893.1| hypothetical protein YQE_07535, partial [Dendroctonus ponderosae]>gi|546684507|gb|ERL94142.1| hypothetical protein D910_11424 [Dendroctonus ponderosae] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q9HC24 355 2.9e-32 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.20850 BP_3 1.00 0.59 370 270015440 EFA11888.1 142 8.2e-07 hypothetical protein TcasGA2_TC016001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20853 BP_3 88.00 25.76 456 506968805 AGM32746.1 215 3.5e-15 elongation of very long chain fatty acids protein 4-like protein [Coptotermes formosanus] -- -- -- -- -- K10249 ELOVL4 elongation of very long chain fatty acids protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10249 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20854 BP_3 16.83 0.78 1328 641649094 XP_008184752.1 787 4.8e-81 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q80WQ9 222 6.4e-17 Zinc finger BED domain-containing protein 4 OS=Mus musculus GN=Zbed4 PE=2 SV=1 PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- KOG1121 Tam3-transposase (Ac family) Cluster-8309.20855 BP_3 13.63 0.51 1576 641652682 XP_008178492.1 558 2.0e-54 PREDICTED: zinc finger BED domain-containing protein 4-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- O96006 165 3.1e-10 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 PF02892//PF14372 BED zinc finger//Domain of unknown function (DUF4413) -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.20856 BP_3 79.51 1.67 2593 642913566 XP_008201065.1 2500 2.2e-279 PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913568|ref|XP_008201066.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913570|ref|XP_008201067.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913572|ref|XP_008201068.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GM59 227 3.3e-17 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.20864 BP_3 57.50 2.02 1667 91087441 XP_975685.1 259 1.0e-19 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27018 160 1.2e-09 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.20868 BP_3 25.20 1.51 1096 270004689 EFA01137.1 281 1.9e-22 hypothetical protein TcasGA2_TC010361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.2087 BP_3 6.61 0.34 1240 642939460 XP_008200411.1 1298 2.5e-140 PREDICTED: lipase member H-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51528 262 1.4e-21 Phospholipase A1 OS=Vespula maculifrons PE=1 SV=1 PF01764//PF00087//PF01383 Lipase (class 3)//Snake toxin//CpcD/allophycocyanin linker domain GO:0009405//GO:0006629 pathogenesis//lipid metabolic process -- -- GO:0005576//GO:0030089 extracellular region//phycobilisome -- -- Cluster-8309.20871 BP_3 94.04 1.33 3707 91091628 XP_970031.1 1240 3.9e-133 PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial [Tribolium castaneum] 780117224 XM_775688.3 40 9.77196e-09 PREDICTED: Strongylocentrotus purpuratus cathepsin L1 (LOC575275), mRNA K00254 DHODH, pyrD dihydroorotate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00254 P32748 1000 1.1e-106 Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Drosophila melanogaster GN=Dhod PE=2 SV=2 PF00112//PF01180//PF03051//PF15163//PF02144//PF04139//PF03060 Papain family cysteine protease//Dihydroorotate dehydrogenase//Peptidase C1-like family//Meiosis-expressed//Repair protein Rad1/Rec1/Rad17//Rad9//Nitronate monooxygenase GO:0006807//GO:0055114//GO:0000077//GO:0006508//GO:0006281 nitrogen compound metabolic process//oxidation-reduction process//DNA damage checkpoint//proteolysis//DNA repair GO:0004197//GO:0016627//GO:0008234//GO:0018580 cysteine-type endopeptidase activity//oxidoreductase activity, acting on the CH-CH group of donors//cysteine-type peptidase activity//nitronate monooxygenase activity GO:0005737//GO:0005634//GO:0030896 cytoplasm//nucleus//checkpoint clamp complex KOG1436 Dihydroorotate dehydrogenase Cluster-8309.20873 BP_3 18.00 0.85 1311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20874 BP_3 245.21 2.52 4985 478258110 ENN78248.1 2446 7.6e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 4.02667e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 2.9e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF09127//PF01433//PF01435//PF08063//PF00400 Leukotriene A4 hydrolase, C-terminal//Peptidase family M1//Peptidase family M48//PADR1 (NUC008) domain//WD domain, G-beta repeat GO:0006508//GO:0019370 proteolysis//leukotriene biosynthetic process GO:0008237//GO:0008270//GO:0003950//GO:0004222//GO:0005515 metallopeptidase activity//zinc ion binding//NAD+ ADP-ribosyltransferase activity//metalloendopeptidase activity//protein binding GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.20876 BP_3 7.34 1.64 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20880 BP_3 127.82 0.52 12165 642913340 XP_008195316.1 11438 0.0e+00 PREDICTED: WD repeat and FYVE domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270002019|gb|EEZ98466.1| hypothetical protein TcasGA2_TC000957 [Tribolium castaneum] 572266379 XM_006611237.1 402 0 PREDICTED: Apis dorsata WD repeat and FYVE domain-containing protein 3-like (LOC102679853), mRNA -- -- -- -- Q8IZQ1 3715 0.0e+00 WD repeat and FYVE domain-containing protein 3 OS=Homo sapiens GN=WDFY3 PE=1 SV=2 PF00400//PF01363 WD domain, G-beta repeat//FYVE zinc finger -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.20885 BP_3 1.00 0.42 404 478259687 ENN79531.1 466 2.4e-44 hypothetical protein YQE_03994, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 348 4.8e-32 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF08477//PF03193//PF00005//PF01926//PF00158//PF13304 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system GO:0007264//GO:0006355 small GTPase mediated signal transduction//regulation of transcription, DNA-templated GO:0005525//GO:0016887//GO:0003924//GO:0008134//GO:0005524 GTP binding//ATPase activity//GTPase activity//transcription factor binding//ATP binding GO:0005667 transcription factor complex -- -- Cluster-8309.2089 BP_3 8.00 0.38 1302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20895 BP_3 14.40 0.69 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20897 BP_3 119.56 2.74 2394 270002312 EEZ98759.1 468 8.4e-44 hypothetical protein TcasGA2_TC001323 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 331 2.7e-29 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 PF07962 Replication Fork Protection Component Swi3 GO:0048478//GO:0007049//GO:0006974 replication fork protection//cell cycle//cellular response to DNA damage stimulus -- -- GO:0005634 nucleus KOG1362 Choline transporter-like protein Cluster-8309.2090 BP_3 3.00 0.61 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20901 BP_3 17.00 2.31 646 270007404 EFA03852.1 251 3.3e-19 hypothetical protein TcasGA2_TC013968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20904 BP_3 724.18 4.61 7862 642916033 XP_008190864.1 3059 0.0e+00 PREDICTED: lisH domain and HEAT repeat-containing protein KIAA1468 homolog [Tribolium castaneum]>gi|270003733|gb|EFA00181.1| hypothetical protein TcasGA2_TC003006 [Tribolium castaneum] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q6P6Y1 798 6.2e-83 LisH domain and HEAT repeat-containing protein KIAA1468 homolog OS=Danio rerio GN=zgc:66014 PE=2 SV=1 PF02985//PF01266//PF06156 HEAT repeat//FAD dependent oxidoreductase//Protein of unknown function (DUF972) GO:0055114//GO:0006260 oxidation-reduction process//DNA replication GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- KOG3923 D-aspartate oxidase Cluster-8309.20905 BP_3 158.96 2.16 3846 270003759 EFA00207.1 1160 7.7e-124 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.58694e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.4e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.20906 BP_3 123.96 1.66 3898 270003759 EFA00207.1 1132 1.4e-120 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.64955e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.20907 BP_3 19.04 0.38 2676 642922229 XP_008193071.1 838 1.2e-86 PREDICTED: thiamine transporter 2-like [Tribolium castaneum]>gi|270007226|gb|EFA03674.1| hypothetical protein TcasGA2_TC013776 [Tribolium castaneum] 642922228 XM_008194849.1 74 8.84313e-28 PREDICTED: Tribolium castaneum thiamine transporter 2-like (LOC661148), mRNA K14610 SLC19A2_3, THTR solute carrier family 19 (thiamine transporter), member 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14610 Q22931 325 1.5e-28 Folate-like transporter 3 OS=Caenorhabditis elegans GN=folt-3 PE=3 SV=3 PF01770//PF07690 Reduced folate carrier//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG3810 Micronutrient transporters (folate transporter family) Cluster-8309.20908 BP_3 6.00 2.01 435 260810226 XP_002599904.1 136 4.8e-06 hypothetical protein BRAFLDRAFT_155447 [Branchiostoma floridae]>gi|229285188|gb|EEN55916.1| hypothetical protein BRAFLDRAFT_155447, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.20909 BP_3 553.00 10.76 2768 224458348 NP_001138958.1 1150 8.0e-123 GPI mannosyltransferase-like [Tribolium castaneum]>gi|642924177|ref|XP_008194184.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|642924179|ref|XP_008194185.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|642924181|ref|XP_008194186.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|642924183|ref|XP_008194187.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|163716754|gb|ABY40601.1| gustatory receptor [Tribolium castaneum]>gi|270007944|gb|EFA04392.1| hypothetical protein TcasGA2_TC014690 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q290J8 680 1.0e-69 GPI mannosyltransferase 2 OS=Drosophila pseudoobscura pseudoobscura GN=GA19757 PE=3 SV=1 PF04188 Mannosyltransferase (PIG-V) GO:0006506 GPI anchor biosynthetic process GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity GO:0000136 alpha-1,6-mannosyltransferase complex KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase Cluster-8309.2091 BP_3 5.00 0.61 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2092 BP_3 13.00 0.68 1209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20921 BP_3 53.50 1.09 2661 282721120 NP_001164234.1 539 5.5e-52 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V6D6 353 8.3e-32 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00213//PF00067 ATP synthase delta (OSCP) subunit//Cytochrome P450 GO:0015986//GO:0055114 ATP synthesis coupled proton transport//oxidation-reduction process GO:0016705//GO:0016491//GO:0046933//GO:0020037//GO:0046872//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//proton-transporting ATP synthase activity, rotational mechanism//heme binding//metal ion binding//iron ion binding GO:0045259 proton-transporting ATP synthase complex KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.20923 BP_3 286.48 10.00 1673 642936481 XP_008198455.1 1480 2.6e-161 PREDICTED: beta-1,3-glucosyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13675 B3GALTL UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13675 Q8BHT6 1156 4.0e-125 Beta-1,3-glucosyltransferase OS=Mus musculus GN=B3galtl PE=2 SV=3 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.20925 BP_3 1.00 7.02 253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20926 BP_3 2.00 1.29 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20927 BP_3 15.00 2.50 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20929 BP_3 4.00 0.75 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20930 BP_3 3.00 4.20 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20931 BP_3 146.50 4.02 2049 546675879 ERL86984.1 1211 5.0e-130 hypothetical protein D910_04387 [Dendroctonus ponderosae] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q6QHF9 483 5.4e-47 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.20935 BP_3 222.46 3.19 3649 270001355 EEZ97802.1 3734 0.0e+00 hypothetical protein TcasGA2_TC000164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UI26 2308 2.3e-258 Importin-11 OS=Homo sapiens GN=IPO11 PE=1 SV=1 PF02985//PF03810 HEAT repeat//Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding -- -- KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) Cluster-8309.20937 BP_3 362.14 5.14 3687 270001355 EEZ97802.1 3734 0.0e+00 hypothetical protein TcasGA2_TC000164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UI26 2308 2.3e-258 Importin-11 OS=Homo sapiens GN=IPO11 PE=1 SV=1 PF03810//PF02985 Importin-beta N-terminal domain//HEAT repeat GO:0006886 intracellular protein transport GO:0005515//GO:0008536 protein binding//Ran GTPase binding -- -- KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) Cluster-8309.20939 BP_3 3.00 0.46 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20941 BP_3 510.75 12.16 2317 478252171 ENN72599.1 2666 1.1e-298 hypothetical protein YQE_10699, partial [Dendroctonus ponderosae] 683898162 XM_009102769.1 128 7.3235e-58 PREDICTED: Serinus canaria myotubularin related protein 2 (MTMR2), mRNA K18081 MTMR1_2 myotubularin-related protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18081 Q5ZIV1 2013 2.3e-224 Myotubularin-related protein 2 OS=Gallus gallus GN=MTMR2 PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.20944 BP_3 2298.70 35.05 3453 642934625 XP_972040.2 2871 0.0e+00 PREDICTED: atrial natriuretic peptide-converting enzyme isoform X1 [Tribolium castaneum] 752897157 XM_011268569.1 48 3.24838e-13 PREDICTED: Camponotus floridanus atrial natriuretic peptide-converting enzyme-like (LOC105257738), mRNA -- -- -- -- Q9Z319 394 1.9e-36 Atrial natriuretic peptide-converting enzyme OS=Mus musculus GN=Corin PE=2 SV=2 PF01392//PF00057//PF00089 Fz domain//Low-density lipoprotein receptor domain class A//Trypsin GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.20959 BP_3 225.05 3.66 3256 270012054 EFA08502.1 1928 5.8e-213 hypothetical protein TcasGA2_TC006154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0PV50 383 3.4e-35 Toll-like receptor 3 OS=Boselaphus tragocamelus GN=TLR3 PE=2 SV=1 PF01582//PF00560//PF13676//PF13855 TIR domain//Leucine Rich Repeat//TIR domain//Leucine rich repeat GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.20960 BP_3 38.94 1.24 1804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20961 BP_3 52.09 0.49 5448 807015446 XP_012155254.1 2244 2.2e-249 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101458667 [Ceratitis capitata] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2189 2.2e-244 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00069//PF07714//PF00628//PF00433//PF07649//PF00130 Protein kinase domain//Protein tyrosine kinase//PHD-finger//Protein kinase C terminal domain//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0055114//GO:0006468//GO:0009069//GO:0016310 intracellular signal transduction//oxidation-reduction process//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0047134//GO:0004674//GO:0005524//GO:0005515 protein kinase activity//protein-disulfide reductase activity//protein serine/threonine kinase activity//ATP binding//protein binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.20963 BP_3 249.99 2.43 5250 807015446 XP_012155254.1 2240 6.2e-249 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101458667 [Ceratitis capitata] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2189 2.1e-244 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00069//PF07649//PF00628//PF00433//PF07714//PF00130 Protein kinase domain//C1-like domain//PHD-finger//Protein kinase C terminal domain//Protein tyrosine kinase//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556//GO:0009069//GO:0006468//GO:0016310 oxidation-reduction process//intracellular signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0047134//GO:0004674//GO:0004672//GO:0005524//GO:0005515 protein-disulfide reductase activity//protein serine/threonine kinase activity//protein kinase activity//ATP binding//protein binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.20965 BP_3 238.29 5.04 2572 642925661 XP_008194659.1 1970 6.1e-218 PREDICTED: ankyrin repeat domain-containing protein 13C [Tribolium castaneum] 170028352 XM_001842008.1 81 1.09114e-31 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q8N6S4 1376 1.9e-150 Ankyrin repeat domain-containing protein 13C OS=Homo sapiens GN=ANKRD13C PE=2 SV=2 PF13606//PF01213//PF00023 Ankyrin repeat//Adenylate cyclase associated (CAP) N terminal//Ankyrin repeat GO:0007010 cytoskeleton organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG0522 Ankyrin repeat protein Cluster-8309.2097 BP_3 1.00 2.40 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20972 BP_3 212.51 7.09 1736 91092400 XP_969218.1 1267 1.4e-136 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 516 6.8e-51 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.20979 BP_3 46.52 0.65 3730 642916189 XP_008190923.1 1780 9.6e-196 PREDICTED: guanine nucleotide-binding protein-like 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36916 1157 6.9e-125 Guanine nucleotide-binding protein-like 1 OS=Mus musculus GN=Gnl1 PE=2 SV=4 PF01926//PF08477//PF03193//PF04548//PF02421//PF06858 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//AIG1 family//Ferrous iron transport protein B//Nucleolar GTP-binding protein 1 (NOG1) GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0015093//GO:0003924 GTP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG1424 Predicted GTP-binding protein MMR1 Cluster-8309.2098 BP_3 33.15 1.06 1803 675380956 KFM73858.1 178 2.7e-10 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20981 BP_3 349.00 6.36 2936 765117892 XP_011472470.1 622 1.4e-61 PREDICTED: LOW QUALITY PROTEIN: gastrula zinc finger protein XlCGF26.1-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- P51523 596 6.1e-60 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF07776//PF16622//PF13912//PF07975//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.20983 BP_3 2.00 4.04 296 642926533 XP_008194909.1 174 1.3e-10 PREDICTED: uncharacterized protein LOC103313433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20984 BP_3 55.49 1.81 1769 642915071 XP_008190398.1 1315 3.8e-142 PREDICTED: protein groucho isoform X4 [Tribolium castaneum] 836708683 XM_012933491.1 309 1.34309e-158 PREDICTED: Sorex araneus transducin-like enhancer of split 3 (TLE3), transcript variant X8, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 1281 1.4e-139 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF03920 Groucho/TLE N-terminal Q-rich domain -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.20985 BP_3 41.00 1.09 2109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10233 Uncharacterized conserved protein CG6151-P -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20986 BP_3 2369.29 75.27 1809 91077536 XP_971011.1 565 3.6e-55 PREDICTED: extensin isoform X1 [Tribolium castaneum]>gi|270002152|gb|EEZ98599.1| hypothetical protein TcasGA2_TC001118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.20987 BP_3 13.57 0.40 1917 478261514 ENN80859.1 442 7.0e-41 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 331 2.1e-29 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20988 BP_3 3.00 1.70 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2099 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01104 Bunyavirus non-structural protein NS-s GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.20990 BP_3 40.78 1.11 2066 332373656 AEE61969.1 1637 2.0e-179 unknown [Dendroctonus ponderosae] 571430507 KF255600.1 387 0 Plutella xylostella protein phosphatase 4 mRNA, complete cds K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 A9JRC7 1586 6.8e-175 Serine/threonine-protein phosphatase 4 catalytic subunit B OS=Danio rerio GN=ppp4cb PE=2 SV=1 PF00149//PF01429 Calcineurin-like phosphoesterase//Methyl-CpG binding domain -- -- GO:0003677//GO:0016787 DNA binding//hydrolase activity GO:0005634 nucleus KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-8309.20991 BP_3 254.12 9.00 1652 728418413 AIY68368.1 984 8.5e-104 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 O62763 507 7.2e-50 Acetylcholinesterase OS=Felis catus GN=ACHE PE=3 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.20992 BP_3 24854.26 658.12 2112 728418413 AIY68368.1 1628 2.3e-178 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 612 6.1e-62 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.20995 BP_3 9.00 5.59 366 759058480 XP_011338475.1 141 1.1e-06 PREDICTED: uncharacterized protein LOC105280011 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00292//PF03615 'Paired box' domain//GCM motif protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.20996 BP_3 325.08 7.31 2434 270005467 EFA01915.1 1081 7.1e-115 hypothetical protein TcasGA2_TC007525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KIA3 574 1.8e-57 LIM domain only protein 3 OS=Bos taurus GN=LMO3 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.20998 BP_3 16.14 0.35 2528 270005467 EFA01915.1 1085 2.5e-115 hypothetical protein TcasGA2_TC007525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YH16 574 1.9e-57 LIM domain only protein 3 OS=Xenopus laevis GN=lmo3 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.210 BP_3 11.48 0.35 1877 642930048 XP_008196227.1 1259 1.2e-135 PREDICTED: dynein intermediate chain 2, ciliary [Tribolium castaneum]>gi|270009429|gb|EFA05877.1| hypothetical protein TcasGA2_TC008686 [Tribolium castaneum] -- -- -- -- -- K10409 DNAI1 dynein intermediate chain 1, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10409 Q16959 679 9.2e-70 Dynein intermediate chain 2, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF04931//PF00400//PF04147//PF02724 DNA polymerase phi//WD domain, G-beta repeat//Nop14-like family//CDC45-like protein GO:0006260//GO:0006351//GO:0006270 DNA replication//transcription, DNA-templated//DNA replication initiation GO:0003677//GO:0005515//GO:0003887 DNA binding//protein binding//DNA-directed DNA polymerase activity GO:0032040//GO:0042575 small-subunit processome//DNA polymerase complex -- -- Cluster-8309.21000 BP_3 4.00 0.85 518 -- -- -- -- -- 462322397 APGK01042850.1 37 5.99799e-08 Dendroctonus ponderosae Seq01042860, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21002 BP_3 554.00 13.48 2272 -- -- -- -- -- 642933272 XM_961737.3 55 2.73241e-17 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21003 BP_3 57.36 1.77 1851 751787804 XP_011203333.1 451 6.1e-42 PREDICTED: laccase-1 [Bactrocera dorsalis] 63079852 DQ011288.1 39 1.73919e-08 Aedes aegypti laccase-like multicopper oxidase 1 (lac1) mRNA, complete cds -- -- -- -- Q8VZA1 140 2.9e-07 Laccase-11 OS=Arabidopsis thaliana GN=LAC11 PE=2 SV=1 PF07731 Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- -- -- Cluster-8309.21006 BP_3 2.00 0.34 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21011 BP_3 828.66 21.33 2164 728418413 AIY68368.1 1628 2.3e-178 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 612 6.3e-62 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859//PF01691 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Adenovirus E1B 19K protein / small t-antigen GO:0043066//GO:0006508//GO:0008152 negative regulation of apoptotic process//proteolysis//metabolic process GO:0008236//GO:0016787//GO:0005521 serine-type peptidase activity//hydrolase activity//lamin binding -- -- -- -- Cluster-8309.21014 BP_3 39007.98 415.75 4814 478250173 ENN70676.1 1254 1.2e-134 hypothetical protein YQE_12621, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q88168 578 1.2e-57 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201//PF04111//PF10152//PF03153 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Autophagy protein Apg6//Predicted coiled-coil domain-containing protein (DUF2360)//Transcription factor IIA, alpha/beta subunit GO:0006914//GO:0006367//GO:0008152 autophagy//transcription initiation from RNA polymerase II promoter//metabolic process GO:0016758 transferase activity, transferring hexosyl groups GO:0071203//GO:0005672 WASH complex//transcription factor TFIIA complex -- -- Cluster-8309.21017 BP_3 34.86 0.99 1984 91092400 XP_969218.1 697 1.9e-70 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 279 2.4e-23 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21021 BP_3 35.31 0.52 3586 642916598 XP_008191833.1 2057 7.0e-228 PREDICTED: limbic system-associated membrane protein-like [Tribolium castaneum] 642916597 XM_008193611.1 147 3.12215e-68 PREDICTED: Tribolium castaneum limbic system-associated membrane protein-like (LOC658191), mRNA -- -- -- -- A2AJ76 323 3.4e-28 Hemicentin-2 OS=Mus musculus GN=Hmcn2 PE=2 SV=1 PF16656//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.21024 BP_3 100.38 2.59 2160 91077604 XP_976419.1 344 1.8e-29 PREDICTED: uncharacterized protein LOC662288 [Tribolium castaneum]>gi|270001560|gb|EEZ98007.1| hypothetical protein TcasGA2_TC000406 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15384//PF09302 PAXX, PAralog of XRCC4 and XLF, also called C9orf142//XLF-Cernunnos, XRcc4-like factor, NHEJ component GO:0006302//GO:0006303//GO:0006281 double-strand break repair//double-strand break repair via nonhomologous end joining//DNA repair -- -- GO:0005634 nucleus -- -- Cluster-8309.21025 BP_3 942.62 25.10 2102 91077604 XP_976419.1 506 2.9e-48 PREDICTED: uncharacterized protein LOC662288 [Tribolium castaneum]>gi|270001560|gb|EEZ98007.1| hypothetical protein TcasGA2_TC000406 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09302//PF15384 XLF-Cernunnos, XRcc4-like factor, NHEJ component//PAXX, PAralog of XRCC4 and XLF, also called C9orf142 GO:0006303//GO:0006259//GO:0006302 double-strand break repair via nonhomologous end joining//DNA metabolic process//double-strand break repair -- -- GO:0005634 nucleus -- -- Cluster-8309.21027 BP_3 24.00 0.79 1760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21028 BP_3 271.90 1.89 7227 642922153 XP_008193036.1 2090 2.1e-231 PREDICTED: afadin isoform X1 [Tribolium castaneum] 462316425 APGK01045079.1 64 8.71492e-22 Dendroctonus ponderosae Seq01045089, whole genome shotgun sequence K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 P55196 950 1.3e-100 Afadin OS=Homo sapiens GN=MLLT4 PE=1 SV=3 PF08272//PF00788//PF11808//PF02064//PF02096//PF00498//PF05745 Topoisomerase I zinc-ribbon-like//Ras association (RalGDS/AF-6) domain//Domain of unknown function (DUF3329)//MAS20 protein import receptor//60Kd inner membrane protein//FHA domain//Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) GO:0051205//GO:0016310//GO:0006886//GO:0007165//GO:0006605//GO:0006265 protein insertion into membrane//phosphorylation//intracellular protein transport//signal transduction//protein targeting//DNA topological change GO:0005515//GO:0003677//GO:0004673//GO:0003918 protein binding//DNA binding//protein histidine kinase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0009365//GO:0016021//GO:0019867//GO:0005742//GO:0005694 protein histidine kinase complex//integral component of membrane//outer membrane//mitochondrial outer membrane translocase complex//chromosome KOG1892 Actin filament-binding protein Afadin Cluster-8309.21029 BP_3 351.12 16.54 1315 332375422 AEE62852.1 479 2.4e-45 unknown [Dendroctonus ponderosae]>gi|478254404|gb|ENN74656.1| hypothetical protein YQE_08773, partial [Dendroctonus ponderosae]>gi|546682350|gb|ERL92298.1| hypothetical protein D910_09615 [Dendroctonus ponderosae] -- -- -- -- -- K10049 CEBPG CCAAT/enhancer binding protein (C/EBP), gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10049 P26801 250 3.6e-20 CCAAT/enhancer-binding protein gamma OS=Rattus norvegicus GN=Cebpg PE=2 SV=2 PF00170//PF07716//PF06005//PF04977 bZIP transcription factor//Basic region leucine zipper//Protein of unknown function (DUF904)//Septum formation initiator GO:0000917//GO:0043093//GO:0007049//GO:0006355 barrier septum assembly//FtsZ-dependent cytokinesis//cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG3119 Basic region leucine zipper transcription factor Cluster-8309.2103 BP_3 46.50 2.71 1119 642935376 XP_008197985.1 484 5.5e-46 PREDICTED: ubiquitin-like-conjugating enzyme ATG10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17888 ATG10L, ATG10 ubiquitin-like-conjugating enzyme ATG10, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K17888 Q9H0Y0 231 4.9e-18 Ubiquitin-like-conjugating enzyme ATG10 OS=Homo sapiens GN=ATG10 PE=1 SV=1 PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex KOG4741 Uncharacterized conserved protein Cluster-8309.21030 BP_3 11.88 0.53 1364 332375422 AEE62852.1 324 2.4e-27 unknown [Dendroctonus ponderosae]>gi|478254404|gb|ENN74656.1| hypothetical protein YQE_08773, partial [Dendroctonus ponderosae]>gi|546682350|gb|ERL92298.1| hypothetical protein D910_09615 [Dendroctonus ponderosae] -- -- -- -- -- K10049 CEBPG CCAAT/enhancer binding protein (C/EBP), gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10049 P26801 185 1.3e-12 CCAAT/enhancer-binding protein gamma OS=Rattus norvegicus GN=Cebpg PE=2 SV=2 PF07716 Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.21037 BP_3 36.25 2.63 957 642921130 XP_975383.3 522 1.8e-50 PREDICTED: glutaredoxin-related protein 5, mitochondrial [Tribolium castaneum] 705677805 XM_010119203.1 44 1.46921e-11 PREDICTED: Chlamydotis macqueenii glutaredoxin 5 (GLRX5), partial mRNA K07390 grxD, GLRX5 monothiol glutaredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K07390 Q86SX6 461 8.9e-45 Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens GN=GLRX5 PE=1 SV=2 PF00462 Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG0911 Glutaredoxin-related protein Cluster-8309.21038 BP_3 40.17 3.33 873 861635019 KMQ91440.1 924 4.1e-97 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] 752860622 XM_011254593.1 184 1.9956e-89 PREDICTED: Camponotus floridanus putative uncharacterized protein FLJ37770 (LOC105249263), mRNA -- -- -- -- Q7JQ07 297 8.5e-26 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.2104 BP_3 5.00 0.33 1012 334854886 AEH05998.1 690 6.4e-70 C type lectin containing domain protein [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21040 BP_3 1096.00 31.51 1968 478255490 ENN75707.1 1590 5.4e-174 hypothetical protein YQE_07668, partial [Dendroctonus ponderosae]>gi|546676746|gb|ERL87702.1| hypothetical protein D910_05092 [Dendroctonus ponderosae] 827025215 LM524981.1 45 8.55226e-12 Strongyloides venezuelensis genome assembly S_venezuelensis_HH1, scaffold SVE_scaffold0000013 K06106 CTTN, EMS1 cortactin http://www.genome.jp/dbget-bin/www_bget?ko:K06106 Q60598 989 1.1e-105 Src substrate cortactin OS=Mus musculus GN=Cttn PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3655 Drebrins and related actin binding proteins Cluster-8309.21042 BP_3 15.38 0.35 2418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21043 BP_3 97.48 2.91 1909 820805536 AKG92759.1 682 1.0e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 2.91943e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 5.1e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF00010//PF01586 Helix-loop-helix DNA-binding domain//Myogenic Basic domain GO:0007517//GO:0006355 muscle organ development//regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.21044 BP_3 12.00 0.50 1457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02066 Metallothionein family 11 -- -- GO:0005507 copper ion binding -- -- -- -- Cluster-8309.21047 BP_3 56.15 0.75 3916 642925611 XP_008194640.1 2652 7.7e-297 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.7e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21048 BP_3 3.03 0.81 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21050 BP_3 9.00 0.93 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21052 BP_3 37.44 0.52 3785 242023873 XP_002432355.1 2239 5.8e-249 paramyosin, long form, putative [Pediculus humanus corporis]>gi|212517778|gb|EEB19617.1| paramyosin, long form, putative [Pediculus humanus corporis] 817211444 XM_012426436.1 154 4.23508e-72 PREDICTED: Orussus abietinus paramyosin, long form-like (LOC105700530), transcript variant X2, mRNA -- -- -- -- P35415 2151 3.8e-240 Paramyosin, long form OS=Drosophila melanogaster GN=Prm PE=1 SV=1 PF06506//PF04513//PF00038//PF01576 Propionate catabolism activator//Baculovirus polyhedron envelope protein, PEP, C terminus//Intermediate filament protein//Myosin tail GO:0000160 phosphorelay signal transduction system GO:0005524//GO:0003677//GO:0005198//GO:0000156//GO:0003774 ATP binding//DNA binding//structural molecule activity//phosphorelay response regulator activity//motor activity GO:0019028//GO:0016459//GO:0019031//GO:0005882 viral capsid//myosin complex//viral envelope//intermediate filament KOG0161 Myosin class II heavy chain Cluster-8309.21053 BP_3 28.00 0.92 1754 -- -- -- -- -- 525346472 KC793944.1 102 1.56675e-43 Scylla paramamosain clone Scpa52 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21056 BP_3 93.11 0.84 5623 270010959 EFA07407.1 2176 1.7e-241 protein C kinase 98E-like protein [Tribolium castaneum] 817193422 XM_012416747.1 273 4.4503e-138 PREDICTED: Orussus abietinus protein kinase C (LOC105695297), transcript variant X5, mRNA K18050 PRKCE novel protein kinase C epsilon type http://www.genome.jp/dbget-bin/www_bget?ko:K18050 P13678 1800 2.9e-199 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF07714//PF07649//PF00628//PF00069//PF00168//PF00433//PF06293 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein tyrosine kinase//C1-like domain//PHD-finger//Protein kinase domain//C2 domain//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0016310//GO:0006468//GO:0009069//GO:0055114//GO:0035556 phosphorylation//protein phosphorylation//serine family amino acid metabolic process//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0016773//GO:0047134//GO:0004672//GO:0004674 ATP binding//protein binding//phosphotransferase activity, alcohol group as acceptor//protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.21057 BP_3 160.93 11.87 945 546681999 ERL91995.1 545 3.9e-53 hypothetical protein D910_09317 [Dendroctonus ponderosae] -- -- -- -- -- K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 354 2.3e-32 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF16499//PF11910 Alpha galactosidase A//Cyanobacterial and plant NDH-1 subunit O GO:0006118//GO:0055114//GO:0005975 obsolete electron transport//oxidation-reduction process//carbohydrate metabolic process GO:0004553//GO:0016655 hydrolase activity, hydrolyzing O-glycosyl compounds//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005886 plasma membrane KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.21059 BP_3 10.08 0.61 1088 642937472 XP_008198851.1 309 1.0e-25 PREDICTED: protein tramtrack, beta isoform-like isoform X13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09167 Domain of unknown function (DUF1942) -- -- -- -- GO:0005615 extracellular space -- -- Cluster-8309.2106 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21060 BP_3 3.00 0.66 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21061 BP_3 7.00 0.72 758 795062975 XP_011873737.1 254 1.7e-19 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Vollenhovia emeryi] 807017284 XM_012305000.1 48 6.88704e-14 PREDICTED: Ceratitis capitata RING finger protein 157 (LOC101463274), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21066 BP_3 188.00 4.96 2119 332373476 AEE61879.1 1603 1.8e-175 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11662 ACTR6, ARP6 actin-related protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11662 Q9DEE9 1021 2.3e-109 Actin-related protein 6 OS=Gallus gallus GN=ACTR6 PE=1 SV=1 PF14659 Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677 DNA binding -- -- KOG0680 Actin-related protein - Arp6p Cluster-8309.21068 BP_3 533.13 7.04 3941 642923020 XP_008200498.1 2991 0.0e+00 PREDICTED: protein ECT2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07139 1475 9.7e-162 Protein ECT2 OS=Mus musculus GN=Ect2 PE=1 SV=2 PF00621//PF02419 RhoGEF domain//PsbL protein GO:0035023//GO:0043087//GO:0015979 regulation of Rho protein signal transduction//regulation of GTPase activity//photosynthesis GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE) Cluster-8309.2107 BP_3 6.00 0.39 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21070 BP_3 34.07 0.54 3336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21071 BP_3 58.72 4.42 932 91085333 XP_970254.1 821 3.8e-85 PREDICTED: translational activator of cytochrome c oxidase 1 [Tribolium castaneum]>gi|270008427|gb|EFA04875.1| hypothetical protein TcasGA2_TC014933 [Tribolium castaneum] -- -- -- -- -- K18189 TACO1 translational activator of cytochrome c oxidase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18189 Q9BSH4 362 2.6e-33 Translational activator of cytochrome c oxidase 1 OS=Homo sapiens GN=TACO1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2972 Uncharacterized conserved protein Cluster-8309.21073 BP_3 20.36 0.79 1531 91088569 XP_973042.1 415 7.5e-38 PREDICTED: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011703|gb|EFA08151.1| hypothetical protein TcasGA2_TC005769 [Tribolium castaneum] -- -- -- -- -- K00022 HADH 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00022 Q9WVK7 265 7.6e-22 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Hadh PE=2 SV=1 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0006552//GO:0006554//GO:0055114//GO:0006568//GO:0006631//GO:0006574//GO:0006550//GO:0006633//GO:0018874 leucine catabolic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//fatty acid metabolic process//valine catabolic process//isoleucine catabolic process//fatty acid biosynthetic process//benzoate metabolic process GO:0003857//GO:0016491//GO:0070403 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//NAD+ binding -- -- KOG2304 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.2108 BP_3 8.00 0.36 1376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21091 BP_3 171.79 2.48 3633 642918209 XP_008191412.1 1177 7.8e-126 PREDICTED: methyltransferase-like protein 9 isoform X1 [Tribolium castaneum]>gi|270004533|gb|EFA00981.1| hypothetical protein TcasGA2_TC003894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EPL4 639 7.8e-65 Methyltransferase-like protein 9 OS=Mus musculus GN=Mettl9 PE=2 SV=1 PF05958//PF08241//PF01234//PF04218 tRNA (Uracil-5-)-methyltransferase//Methyltransferase domain//NNMT/PNMT/TEMT family//CENP-B N-terminal DNA-binding domain GO:0006396//GO:0009451//GO:0008152 RNA processing//RNA modification//metabolic process GO:0008173//GO:0003677//GO:0008168 RNA methyltransferase activity//DNA binding//methyltransferase activity -- -- KOG3987 Uncharacterized conserved protein DREV/CGI-81 Cluster-8309.21094 BP_3 49.46 0.74 3501 642926818 XP_001810169.2 2170 5.4e-241 PREDICTED: uncharacterized protein LOC100142170 isoform X1 [Tribolium castaneum] 241559510 XM_002400536.1 97 1.90009e-40 Ixodes scapularis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF17096//PF06870//PF14719 Altered inheritance of mitochondria protein 3//A49-like RNA polymerase I associated factor//Phosphotyrosine interaction domain (PTB/PID) GO:0051016//GO:0006206//GO:0006351//GO:0006144 barbed-end actin filament capping//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005730//GO:0005634//GO:0030479 nucleolus//nucleus//actin cortical patch -- -- Cluster-8309.21098 BP_3 1.00 0.49 388 748995286 AJE75665.1 447 3.7e-42 putative glycosyl hydrolase [Chrysomela lapponica] 642929886 XM_970573.2 45 1.57163e-12 PREDICTED: Tribolium castaneum myrosinase 1 (LOC664577), mRNA K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 381 6.8e-36 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.211 BP_3 7.00 0.31 1387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21103 BP_3 17.03 1.48 847 646709824 KDR15513.1 235 3.1e-17 hypothetical protein L798_10579 [Zootermopsis nevadensis] -- -- -- -- -- K10848 ERCC4, XPF DNA excision repair protein ERCC-4 http://www.genome.jp/dbget-bin/www_bget?ko:K10848 Q5ZLK8 204 5.0e-15 UPF0669 protein C6orf120 homolog OS=Gallus gallus GN=RCJMB04_5l6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21104 BP_3 268.00 6.88 2170 642914097 XP_008201541.1 922 1.7e-96 PREDICTED: uncharacterized serine-rich protein C215.13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.21105 BP_3 31.71 0.72 2421 478263645 ENN81951.1 1325 3.6e-143 hypothetical protein YQE_01662, partial [Dendroctonus ponderosae]>gi|546676684|gb|ERL87640.1| hypothetical protein D910_05031 [Dendroctonus ponderosae] -- -- -- -- -- K08870 TWF twinfilin http://www.genome.jp/dbget-bin/www_bget?ko:K08870 Q17A58 1045 4.3e-112 Twinfilin OS=Aedes aegypti GN=twf PE=3 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein Cluster-8309.21106 BP_3 2.00 5.75 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21107 BP_3 20.26 0.48 2338 195476227 XP_002086044.1 153 2.8e-07 GE11323 [Drosophila yakuba]>gi|194185903|gb|EDW99514.1| GE11323 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08714//PF11857 Formaldehyde-activating enzyme (Fae)//Domain of unknown function (DUF3377) GO:0016051 carbohydrate biosynthetic process GO:0016840//GO:0004222 carbon-nitrogen lyase activity//metalloendopeptidase activity -- -- -- -- Cluster-8309.21108 BP_3 15.46 1.23 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21109 BP_3 96.00 7.87 880 642917592 XP_008191271.1 334 1.1e-28 PREDICTED: UPF0488 protein CG14286 [Tribolium castaneum]>gi|270003417|gb|EEZ99864.1| hypothetical protein TcasGA2_TC002646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VE11 233 2.2e-18 UPF0488 protein CG14286 OS=Drosophila melanogaster GN=CG14286 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2111 BP_3 621.63 30.17 1285 170062970 XP_001866901.1 286 5.7e-23 Gly-rich protein [Culex quinquefasciatus]>gi|167880749|gb|EDS44132.1| Gly-rich protein [Culex quinquefasciatus] 751774435 XM_011215544.1 86 8.93273e-35 PREDICTED: Bactrocera dorsalis glycine-rich cell wall structural protein (LOC105233452), mRNA -- -- -- -- -- -- -- -- PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.21110 BP_3 40.78 0.40 5253 815810115 XP_012225947.1 224 3.6e-15 PREDICTED: zinc finger protein 677-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q7KQZ4 165 1.0e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF03002//PF00096//PF13465 Somatostatin/Cortistatin family//Zinc finger, C2H2 type//Zinc-finger double domain GO:0007165 signal transduction GO:0046872//GO:0005179 metal ion binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.21111 BP_3 9.15 0.56 1077 91084977 XP_972224.1 264 1.7e-20 PREDICTED: myotrophin [Tribolium castaneum]>gi|270008542|gb|EFA04990.1| hypothetical protein TcasGA2_TC015069 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T2B9 149 1.5e-08 Myotrophin OS=Danio rerio GN=mtpn PE=3 SV=1 PF13606 Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4214 Myotrophin and similar proteins Cluster-8309.21112 BP_3 110.52 6.77 1079 642916794 XP_008199506.1 692 4.0e-70 PREDICTED: transmembrane protein 70 homolog, mitochondrial [Tribolium castaneum]>gi|270003058|gb|EEZ99505.1| hypothetical protein TcasGA2_TC000082 [Tribolium castaneum] -- -- -- -- -- K17966 TMEM70 transmembrane protein 70, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17966 Q95SS8 445 7.2e-43 Transmembrane protein 70 homolog, mitochondrial OS=Drosophila melanogaster GN=CG7506 PE=2 SV=1 PF03977 Na+-transporting oxaloacetate decarboxylase beta subunit GO:0006814 sodium ion transport GO:0016829 lyase activity -- -- KOG4478 Uncharacterized membrane protein Cluster-8309.21115 BP_3 1419.31 44.56 1827 727098862 AIY54293.1 2157 9.0e-240 actin 1 [Colaphellus bowringi] 727098861 KJ534552.1 411 0 Colaphellus bowringi actin 1 mRNA, complete cds K18584 ACTR3, ARP3 actin-related protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18584 P32392 2008 7.0e-224 Actin-related protein 3 OS=Drosophila melanogaster GN=Arp3 PE=2 SV=3 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0678 Actin-related protein Arp2/3 complex, subunit Arp3 Cluster-8309.21119 BP_3 140.01 3.53 2205 642937652 XP_966876.3 600 3.8e-59 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62836 366 2.1e-33 Zinc finger X-chromosomal protein OS=Bos taurus GN=ZFX PE=2 SV=2 PF00096//PF13465//PF06784//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Uncharacterised protein family (UPF0240)//Zinc-finger associated domain (zf-AD) GO:0032981 mitochondrial respiratory chain complex I assembly GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.2112 BP_3 4.00 0.90 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21121 BP_3 96.64 1.33 3788 642937407 XP_008198823.1 2845 0.0e+00 PREDICTED: dynamin isoform X2 [Tribolium castaneum] -- -- -- -- -- K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 2587 1.1e-290 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF01031//PF01926//PF02212 Dynamin central region//50S ribosome-binding GTPase//Dynamin GTPase effector domain -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.21122 BP_3 2.00 28.64 234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21123 BP_3 47.80 0.83 3063 642919204 XP_008191779.1 1144 4.4e-122 PREDICTED: POU domain protein 2 [Tribolium castaneum] 820841750 XM_012483764.1 143 4.45477e-66 PREDICTED: Apis florea POU domain protein 2, isoform A-like (LOC100872881), transcript variant X3, mRNA K09364 POU2F, OTF POU domain transcription factor, class 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09364 P31368 732 1.1e-75 Protein nubbin OS=Drosophila melanogaster GN=nub PE=2 SV=1 PF03153//PF05920//PF00157//PF00046//PF00841 Transcription factor IIA, alpha/beta subunit//Homeobox KN domain//Pou domain - N-terminal to homeobox domain//Homeobox domain//Sperm histone P2 GO:0006355//GO:0006367//GO:0007283 regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter//spermatogenesis GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0000786//GO:0005667//GO:0005672 nucleus//nucleosome//transcription factor complex//transcription factor TFIIA complex -- -- Cluster-8309.21124 BP_3 1276.73 11.61 5593 642935437 XP_971822.3 1690 3.9e-185 PREDICTED: pancreatic triacylglycerol lipase [Tribolium castaneum] -- -- -- -- -- K11092 SNRPA1 U2 small nuclear ribonucleoprotein A' http://www.genome.jp/dbget-bin/www_bget?ko:K11092 P09661 702 5.9e-72 U2 small nuclear ribonucleoprotein A' OS=Homo sapiens GN=SNRPA1 PE=1 SV=2 PF07714//PF00975//PF00069//PF02230//PF13855 Protein tyrosine kinase//Thioesterase domain//Protein kinase domain//Phospholipase/Carboxylesterase//Leucine rich repeat GO:0009058//GO:0006468 biosynthetic process//protein phosphorylation GO:0004672//GO:0005515//GO:0016787//GO:0005524//GO:0016788 protein kinase activity//protein binding//hydrolase activity//ATP binding//hydrolase activity, acting on ester bonds -- -- KOG1644 U2-associated snRNP A' protein Cluster-8309.21125 BP_3 7.00 0.31 1367 478257239 ENN77402.1 305 3.8e-25 hypothetical protein YQE_06227, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21127 BP_3 7.00 0.76 735 91078008 XP_969762.1 273 1.1e-21 PREDICTED: fatty acid-binding protein, liver [Tribolium castaneum]>gi|270002862|gb|EEZ99309.1| cellular FABP-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2113 BP_3 8.00 0.78 785 642933681 XP_008197519.1 260 3.6e-20 PREDICTED: uncharacterized protein LOC103314155 [Tribolium castaneum]>gi|270012583|gb|EFA09031.1| hypothetical protein TcasGA2_TC006744 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00830 Ribosomal L28 family GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.21131 BP_3 353.14 9.72 2042 91090139 XP_971650.1 1351 2.9e-146 PREDICTED: WEB family protein At3g02930, chloroplastic [Tribolium castaneum]>gi|270013743|gb|EFA10191.1| hypothetical protein TcasGA2_TC012383 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050//PF10473//PF12467//PF13851//PF05929//PF06156//PF07851//PF04111 Flagellar FliJ protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Cucumber mosaic virus 1a protein family//Growth-arrest specific micro-tubule binding//Phage capsid scaffolding protein (GPO) serine peptidase//Protein of unknown function (DUF972)//TMPIT-like protein//Autophagy protein Apg6 GO:0019069//GO:0048870//GO:0071973//GO:0006935//GO:0006260//GO:0006914 viral capsid assembly//cell motility//bacterial-type flagellum-dependent cell motility//chemotaxis//DNA replication//autophagy GO:0016817//GO:0003774//GO:0042803//GO:0008168//GO:0008134//GO:0045502 hydrolase activity, acting on acid anhydrides//motor activity//protein homodimerization activity//methyltransferase activity//transcription factor binding//dynein binding GO:0016020//GO:0005667//GO:0030286//GO:0009288//GO:0031514//GO:0016021 membrane//transcription factor complex//dynein complex//bacterial-type flagellum//motile cilium//integral component of membrane -- -- Cluster-8309.21132 BP_3 112.99 0.82 6910 91076790 XP_974060.1 950 3.1e-99 PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|642913035|ref|XP_008201360.1| PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|270001925|gb|EEZ98372.1| hypothetical protein TcasGA2_TC000831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88879 361 2.5e-32 Apoptotic protease-activating factor 1 OS=Mus musculus GN=Apaf1 PE=1 SV=3 PF01637//PF00400//PF00931//PF07569//PF00619 Archaeal ATPase//WD domain, G-beta repeat//NB-ARC domain//TUP1-like enhancer of split//Caspase recruitment domain GO:0006355//GO:0042981 regulation of transcription, DNA-templated//regulation of apoptotic process GO:0005524//GO:0005515//GO:0043531 ATP binding//protein binding//ADP binding GO:0005634 nucleus -- -- Cluster-8309.21133 BP_3 21.54 0.61 1993 270008834 EFA05282.1 970 4.3e-102 hypothetical protein TcasGA2_TC015439 [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02599 388 5.4e-36 Calmodulin OS=Dictyostelium discoideum GN=calA PE=1 SV=3 PF00036//PF10591//PF13833//PF13405//PF13499//PF13202//PF12763 EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.21135 BP_3 777.20 47.28 1084 478263679 ENN81985.1 1350 2.0e-146 hypothetical protein YQE_01696, partial [Dendroctonus ponderosae]>gi|546676718|gb|ERL87674.1| hypothetical protein D910_05064 [Dendroctonus ponderosae] 557016035 XM_006008402.1 52 5.96892e-16 PREDICTED: Latimeria chalumnae unconventional myosin-Ig-like (LOC102346417), partial mRNA K10358 MYO6 myosin VI http://www.genome.jp/dbget-bin/www_bget?ko:K10358 Q01989 1088 2.0e-117 Myosin heavy chain 95F OS=Drosophila melanogaster GN=jar PE=2 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0163 Myosin class VI heavy chain Cluster-8309.21138 BP_3 48.69 0.37 6586 478254682 ENN74923.1 1035 4.1e-109 hypothetical protein YQE_08501, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H221 254 6.2e-20 ATP-binding cassette sub-family G member 8 OS=Homo sapiens GN=ABCG8 PE=1 SV=1 PF01061//PF00005//PF05297 ABC-2 type transporter//ABC transporter//Herpesvirus latent membrane protein 1 (LMP1) GO:0019087 transformation of host cell by virus GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.21139 BP_3 17.97 0.38 2546 642918750 XP_008191568.1 609 4.0e-60 PREDICTED: palmitoyltransferase ZDHHC7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NYG2 282 1.4e-23 Palmitoyltransferase ZDHHC3 OS=Homo sapiens GN=ZDHHC3 PE=1 SV=2 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.2114 BP_3 4.00 4.25 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21144 BP_3 319.11 7.24 2417 478260221 ENN79984.1 223 2.2e-15 hypothetical protein YQE_03578, partial [Dendroctonus ponderosae]>gi|546675215|gb|ERL86451.1| hypothetical protein D910_03858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2115 BP_3 70.00 2.01 1972 642910848 XP_008193434.1 253 5.9e-19 PREDICTED: uncharacterized protein LOC100142427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21150 BP_3 21.50 0.38 3022 91089397 XP_974004.1 3313 0.0e+00 PREDICTED: pyridoxal-dependent decarboxylase domain-containing protein 1 [Tribolium castaneum]>gi|270011423|gb|EFA07871.1| hypothetical protein TcasGA2_TC005445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DF78 994 4.4e-106 Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Xenopus laevis GN=pdxdc1 PE=2 SV=1 PF01212//PF00282//PF00964 Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain//Elicitin GO:0006520//GO:0009405//GO:0019752//GO:0006952 cellular amino acid metabolic process//pathogenesis//carboxylic acid metabolic process//defense response GO:0016829//GO:0016831//GO:0030170 lyase activity//carboxy-lyase activity//pyridoxal phosphate binding GO:0005576 extracellular region KOG0630 Predicted pyridoxal-dependent decarboxylase Cluster-8309.21151 BP_3 99.00 5.03 1241 546673461 ERL85059.1 703 2.4e-71 hypothetical protein D910_02482 [Dendroctonus ponderosae] -- -- -- -- -- K11666 INO80B, ZNHIT4, PAPA1 INO80 complex subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K11666 Q99PT3 194 1.1e-13 INO80 complex subunit B OS=Mus musculus GN=Ino80b PE=1 SV=2 PF04795 PAPA-1-like conserved region -- -- -- -- GO:0031011 Ino80 complex -- -- Cluster-8309.21154 BP_3 123.74 1.35 4719 642913900 XP_008201205.1 4652 0.0e+00 PREDICTED: anaphase-promoting complex subunit 1 [Tribolium castaneum] -- -- -- -- -- K03348 APC1 anaphase-promoting complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03348 P53995 2470 4.9e-277 Anaphase-promoting complex subunit 1 OS=Mus musculus GN=Anapc1 PE=2 SV=2 PF07475 HPr Serine kinase C-terminal domain GO:0000160//GO:0006109//GO:0016310 phosphorelay signal transduction system//regulation of carbohydrate metabolic process//phosphorylation GO:0000155//GO:0005524//GO:0004672 phosphorelay sensor kinase activity//ATP binding//protein kinase activity GO:0009365 protein histidine kinase complex KOG1858 Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) Cluster-8309.21156 BP_3 772.74 4.52 8528 642916934 XP_008199560.1 3515 0.0e+00 PREDICTED: serine/threonine-protein kinase HSL1 [Tribolium castaneum] 642916933 XM_008201338.1 374 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase HSL1 (LOC660568), mRNA K08853 AAK AP2-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08853 F1MH24 1145 3.9e-123 AP2-associated protein kinase 1 OS=Bos taurus GN=AAK1 PE=1 SV=2 PF00069//PF07714//PF07578 Protein kinase domain//Protein tyrosine kinase//Lipid A Biosynthesis N-terminal domain GO:0006468//GO:0009245 protein phosphorylation//lipid A biosynthetic process GO:0008915//GO:0004672//GO:0005524 lipid-A-disaccharide synthase activity//protein kinase activity//ATP binding -- -- KOG1989 ARK protein kinase family Cluster-8309.21159 BP_3 212.92 4.54 2550 91088303 XP_969204.1 1591 5.4e-174 PREDICTED: limbic system-associated membrane protein [Tribolium castaneum]>gi|270012163|gb|EFA08611.1| hypothetical protein TcasGA2_TC006274 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 318 9.1e-28 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF00041//PF13895//PF04006//PF05790 Fibronectin type III domain//Immunoglobulin domain//Mpp10 protein//Immunoglobulin C2-set domain GO:0006364//GO:0007155 rRNA processing//cell adhesion GO:0005515 protein binding GO:0034457//GO:0005634//GO:0005732//GO:0016021 Mpp10 complex//nucleus//small nucleolar ribonucleoprotein complex//integral component of membrane -- -- Cluster-8309.2116 BP_3 61.95 0.67 4769 270004055 EFA00503.1 437 6.6e-40 hypothetical protein TcasGA2_TC003365 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21160 BP_3 27.36 0.81 1918 270002713 EEZ99160.1 224 1.3e-15 hypothetical protein TcasGA2_TC016159 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04561 RNA polymerase Rpb2, domain 2 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.21161 BP_3 1.00 4.87 264 817060055 XP_012251562.1 266 2.4e-21 PREDICTED: alpha-amylase-like isoform X1 [Athalia rosae] -- -- -- -- -- K01176 E3.2.1.1, amyA, malS alpha-amylase http://www.genome.jp/dbget-bin/www_bget?ko:K01176 P09107 263 2.2e-22 Alpha-amylase (Fragment) OS=Tribolium castaneum PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2212 Alpha-amylase Cluster-8309.21162 BP_3 196.00 9.45 1291 4557953 1TMQ 1360 1.7e-147 Chain A, Structure Of Tenebrio Molitor Larval Alpha-Amylase In Complex With Ragi Bifunctional Inhibitor>gi|7766814|pdb|1CLV|A Chain A, Yellow Meal Worm Alpha-Amylase In Complex With The Amaranth Alpha-Amylase Inhibitor>gi|157831531|pdb|1JAE|A Chain A, Structure Of Tenebrio Molitor Larval Alpha-Amylase -- -- -- -- -- K01176 E3.2.1.1, amyA, malS alpha-amylase http://www.genome.jp/dbget-bin/www_bget?ko:K01176 P56634 1360 6.9e-149 Alpha-amylase OS=Tenebrio molitor PE=1 SV=1 PF02806//PF00128//PF07745 Alpha amylase, C-terminal all-beta domain//Alpha amylase, catalytic domain//Glycosyl hydrolase family 53 GO:0005975//GO:0008152 carbohydrate metabolic process//metabolic process GO:0015926//GO:0016798//GO:0003824//GO:0043169 glucosidase activity//hydrolase activity, acting on glycosyl bonds//catalytic activity//cation binding -- -- KOG2212 Alpha-amylase Cluster-8309.21164 BP_3 16.44 1.07 1029 478252396 ENN72822.1 955 1.2e-100 hypothetical protein YQE_10625, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R599 496 8.4e-49 Translin-associated protein X OS=Macaca fascicularis GN=TSNAX PE=2 SV=1 PF01997 Translin family -- -- GO:0043565 sequence-specific DNA binding -- -- KOG3066 Translin-associated protein X Cluster-8309.21165 BP_3 145.57 3.21 2480 642915433 XP_008190613.1 571 9.9e-56 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08445//PF13673//PF13302//PF00583//PF13508//PF12142 FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Polyphenol oxidase middle domain GO:0055114//GO:0006570//GO:0042967//GO:0006118 oxidation-reduction process//tyrosine metabolic process//acyl-carrier-protein biosynthetic process//obsolete electron transport GO:0008080//GO:0004097//GO:0016747 N-acetyltransferase activity//catechol oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.21168 BP_3 106.52 1.71 3293 642935257 XP_008197935.1 400 8.9e-36 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 -- -- -- -- PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.2117 BP_3 11.00 0.98 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12326//PF02921 N-glycosylation protein//Ubiquinol cytochrome reductase transmembrane region GO:0034599//GO:0006118//GO:0006119//GO:0015992//GO:0055114 cellular response to oxidative stress//obsolete electron transport//oxidative phosphorylation//proton transport//oxidation-reduction process GO:0008121 ubiquinol-cytochrome-c reductase activity GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.21173 BP_3 99.23 1.65 3199 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21176 BP_3 5.00 19.63 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.2118 BP_3 4.00 1.06 473 817063364 XP_012253379.1 210 1.4e-14 PREDICTED: collagen alpha-1(XI) chain-like [Athalia rosae] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21180 BP_3 323.45 3.54 4690 594048002 XP_006048406.1 446 5.9e-41 PREDICTED: zinc finger protein 572 isoform X1 [Bubalus bubalis]>gi|594048004|ref|XP_006048407.1| PREDICTED: zinc finger protein 572 isoform X2 [Bubalus bubalis]>gi|594048006|ref|XP_006048408.1| PREDICTED: zinc finger protein 572 isoform X3 [Bubalus bubalis] 817183731 XM_012422552.1 277 2.21539e-140 PREDICTED: Orussus abietinus zinc finger protein rotund-like (LOC105698363), transcript variant X1, mRNA -- -- -- -- Q32KN0 433 7.7e-41 Zinc finger protein 572 OS=Bos taurus GN=ZNF572 PE=2 SV=1 PF16622//PF01095//PF13465//PF00096 zinc-finger C2H2-type//Pectinesterase//Zinc-finger double domain//Zinc finger, C2H2 type GO:0005982//GO:0005985//GO:0042545 starch metabolic process//sucrose metabolic process//cell wall modification GO:0046872//GO:0030599 metal ion binding//pectinesterase activity GO:0005618 cell wall -- -- Cluster-8309.21184 BP_3 920.63 24.44 2107 478253814 ENN74106.1 498 2.5e-47 hypothetical protein YQE_09079, partial [Dendroctonus ponderosae]>gi|546684620|gb|ERL94237.1| hypothetical protein D910_11518 [Dendroctonus ponderosae] -- -- -- -- -- K03122 TFIIA1, GTF2A1, TOA1 transcription initiation factor TFIIA large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03122 P52654 272 1.6e-22 Transcription initiation factor IIA subunit 1 OS=Drosophila melanogaster GN=TfIIA-L PE=1 SV=2 PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex KOG2652 RNA polymerase II transcription initiation factor TFIIA, large chain Cluster-8309.21185 BP_3 18.00 1.27 975 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21186 BP_3 200.83 2.17 4755 91081535 XP_974904.1 2249 5.1e-250 PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921048|ref|XP_008192670.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921050|ref|XP_008192671.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|270006169|gb|EFA02617.1| hypothetical protein TcasGA2_TC008337 [Tribolium castaneum] 642921051 XM_969811.2 41 3.49261e-09 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase Suv4-20 (LOC663776), transcript variant X3, mRNA K11429 SUV420H histone-lysine N-methyltransferase SUV420H http://www.genome.jp/dbget-bin/www_bget?ko:K11429 Q9W5E0 1092 3.0e-117 Histone-lysine N-methyltransferase Suv4-20 OS=Drosophila melanogaster GN=Hmt4-20 PE=1 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2589 Histone tail methylase Cluster-8309.21187 BP_3 188.01 6.14 1768 308191588 A2V735.1 1106 6.5e-118 RecName: Full=Tropomyosin; AltName: Full=Tropomyosin, slow-tonic isoform; Short=Tm-Chio-tonic [Chionoecetes opilio]>gi|125995167|dbj|BAF47267.1| tropomyosin slow-tonic isoform [Chionoecetes opilio] 125995170 AB270636.1 860 0 Erimacrus isenbeckii Tm-Erii-tonic mRNA for tropomyosin slow-tonic isoform, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 O44119 1115 2.4e-120 Tropomyosin OS=Homarus americanus GN=TM1 PE=1 SV=1 PF08702//PF00769//PF05557//PF07926//PF10473//PF05739//PF06160//PF06109//PF16716//PF06008//PF14073//PF07167//PF00435//PF04111//PF06009 Fibrinogen alpha/beta chain family//Ezrin/radixin/moesin family//Mitotic checkpoint protein//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Septation ring formation regulator, EzrA//Haemolysin E (HlyE)//Bone marrow stromal antigen 2//Laminin Domain I//Centrosome localisation domain of Cep57//Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus//Spectrin repeat//Autophagy protein Apg6//Laminin Domain II GO:0051607//GO:0007094//GO:0007155//GO:0030155//GO:0009405//GO:0007165//GO:0044179//GO:0030334//GO:0051258//GO:0006914//GO:0042619//GO:0000921//GO:0030168//GO:0006606//GO:0045995 defense response to virus//mitotic spindle assembly checkpoint//cell adhesion//regulation of cell adhesion//pathogenesis//signal transduction//hemolysis in other organism//regulation of cell migration//protein polymerization//autophagy//poly-hydroxybutyrate biosynthetic process//septin ring assembly//platelet activation//protein import into nucleus//regulation of embryonic development GO:0042802//GO:0005515//GO:0043015//GO:0042803//GO:0008092//GO:0030674//GO:0008134//GO:0045502//GO:0005102 identical protein binding//protein binding//gamma-tubulin binding//protein homodimerization activity//cytoskeletal protein binding//protein binding, bridging//transcription factor binding//dynein binding//receptor binding GO:0016021//GO:0005940//GO:0005737//GO:0030286//GO:0005667//GO:0019898//GO:0045298//GO:0005577 integral component of membrane//septin ring//cytoplasm//dynein complex//transcription factor complex//extrinsic component of membrane//tubulin complex//fibrinogen complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.21189 BP_3 11.19 0.40 1624 642925505 XP_008194578.1 806 3.6e-83 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase [Tribolium castaneum]>gi|270008695|gb|EFA05143.1| hypothetical protein TcasGA2_TC015260 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q7SY06 390 2.6e-36 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio GN=hacd3 PE=2 SV=2 PF06687//PF04999 SUR7/PalI family//Cell division protein FtsL GO:0051301//GO:0007049 cell division//cell cycle -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.2119 BP_3 6.00 0.93 603 546675233 ERL86469.1 178 8.9e-11 hypothetical protein D910_03875, partial [Dendroctonus ponderosae] 462369053 APGK01026348.1 75 5.29894e-29 Dendroctonus ponderosae Seq01026358, whole genome shotgun sequence K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 144 3.2e-08 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21190 BP_3 261.09 1.98 6645 642918326 XP_008199092.1 2616 2.0e-292 PREDICTED: protein Shroom [Tribolium castaneum] -- -- -- -- -- K18625 SHROOM protein Shroom http://www.genome.jp/dbget-bin/www_bget?ko:K18625 Q09JY9 372 1.3e-33 Protein Shroom2 OS=Xenopus tropicalis GN=shroom2 PE=2 SV=1 PF07353 Uroplakin II GO:0061024 membrane organization -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.21194 BP_3 23.23 0.94 1486 642918318 XP_008191457.1 453 2.9e-42 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642918317 XM_008193235.1 135 5.98125e-62 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC656006), mRNA K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9ERC8 218 2.1e-16 Down syndrome cell adhesion molecule homolog OS=Mus musculus GN=Dscam PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21195 BP_3 288.34 5.00 3071 332376975 AEE63627.1 1501 1.8e-163 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 141 5.77784e-65 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1367 2.5e-149 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF04545//PF00382//PF01857//PF02984 Sigma-70, region 4//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain//Cyclin, C-terminal domain GO:0051726//GO:0006352//GO:0006355 regulation of cell cycle//DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0017025//GO:0016987 DNA binding//transcription factor activity, sequence-specific DNA binding//TBP-class protein binding//sigma factor activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1597 Transcription initiation factor TFIIB Cluster-8309.21196 BP_3 215.06 5.80 2080 546677470 ERL88302.1 1949 1.4e-215 hypothetical protein D910_05689 [Dendroctonus ponderosae] 642912507 XM_966689.2 445 0 PREDICTED: Tribolium castaneum cyclin dependent kinase 8 (LOC660461), mRNA K02208 CDK8_11 cyclin-dependent kinase 8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K02208 Q17IE8 1791 1.2e-198 Cyclin-dependent kinase 8 OS=Aedes aegypti GN=Cdk8 PE=3 SV=2 PF02932//PF02724//PF07714//PF06213//PF04973//PF00069 Neurotransmitter-gated ion-channel transmembrane region//CDC45-like protein//Protein tyrosine kinase//Cobalamin biosynthesis protein CobT//Nicotinamide mononucleotide transporter//Protein kinase domain GO:0009236//GO:0006811//GO:0034258//GO:0006270//GO:0006468 cobalamin biosynthetic process//ion transport//nicotinamide riboside transport//DNA replication initiation//protein phosphorylation GO:0004672//GO:0034257//GO:0005524 protein kinase activity//nicotinamide riboside transmembrane transporter activity//ATP binding GO:0016020 membrane KOG0666 Cyclin C-dependent kinase CDK8 Cluster-8309.21199 BP_3 160.99 1.93 4321 478252657 ENN73061.1 1798 9.1e-198 hypothetical protein YQE_10331, partial [Dendroctonus ponderosae] -- -- -- -- -- K10770 ALKBH8 alkylated DNA repair protein alkB homolog 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10770 Q07G10 1262 5.3e-137 Alkylated DNA repair protein alkB homolog 8 OS=Xenopus tropicalis GN=alkbh8 PE=2 SV=2 PF01209//PF04083//PF01738//PF08241//PF08168 ubiE/COQ5 methyltransferase family//Partial alpha/beta-hydrolase lipase region//Dienelactone hydrolase family//Methyltransferase domain//NUC205 domain GO:0006629//GO:0008152 lipid metabolic process//metabolic process GO:0016787//GO:0008168 hydrolase activity//methyltransferase activity GO:0005634 nucleus -- -- Cluster-8309.2120 BP_3 533.00 28.32 1199 642937060 XP_008198673.1 189 9.4e-12 PREDICTED: uncharacterized protein LOC103314414 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21200 BP_3 194.06 3.79 2762 91080721 XP_975378.1 1530 6.9e-167 PREDICTED: lipase 3 [Tribolium castaneum]>gi|270005867|gb|EFA02315.1| hypothetical protein TcasGA2_TC007981 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 Q5VXJ0 718 4.1e-74 Lipase member K OS=Homo sapiens GN=LIPK PE=2 SV=2 PF01738//PF08168//PF04083 Dienelactone hydrolase family//NUC205 domain//Partial alpha/beta-hydrolase lipase region GO:0016042//GO:0006629 lipid catabolic process//lipid metabolic process GO:0016788//GO:0016787 hydrolase activity, acting on ester bonds//hydrolase activity GO:0005634 nucleus KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.21201 BP_3 28.00 1.34 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21203 BP_3 176.98 6.29 1647 642925155 XP_008194449.1 1294 9.6e-140 PREDICTED: zinc finger protein 431-like [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 492 3.9e-48 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF16622//PF07776//PF13912//PF05443//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//ROS/MUCR transcriptional regulator protein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.21204 BP_3 252.97 11.04 1396 91079146 XP_966535.1 641 4.3e-64 PREDICTED: ankyrin repeat domain-containing protein 49 [Tribolium castaneum]>gi|270004231|gb|EFA00679.1| hypothetical protein TcasGA2_TC003556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VE42 396 4.5e-37 Ankyrin repeat domain-containing protein 49 OS=Mus musculus GN=Ankrd49 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21205 BP_3 87.85 6.24 970 91077632 XP_974008.1 675 3.4e-68 PREDICTED: venom acid phosphatase Acph-1 [Tribolium castaneum]>gi|270002186|gb|EEZ98633.1| hypothetical protein TcasGA2_TC001160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLY5 232 3.2e-18 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- -- -- Cluster-8309.21210 BP_3 49.33 1.06 2534 194578879 NP_001034528.2 1164 1.7e-124 distal-less [Tribolium castaneum]>gi|270011030|gb|EFA07478.1| distal-less [Tribolium castaneum] 194578878 NM_001039439.2 508 0 Tribolium castaneum distal-less (Dll), mRNA K18488 DLX2 homeobox protein DLX2 http://www.genome.jp/dbget-bin/www_bget?ko:K18488 P20009 476 4.3e-46 Homeotic protein distal-less OS=Drosophila melanogaster GN=Dll PE=2 SV=3 PF01787//PF05920//PF00046 Ilarvirus coat protein//Homeobox KN domain//Homeobox domain GO:0006355//GO:0006413 regulation of transcription, DNA-templated//translational initiation GO:0043565//GO:0003723//GO:0003677 sequence-specific DNA binding//RNA binding//DNA binding GO:0019012 virion KOG0850 Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains Cluster-8309.21211 BP_3 128.67 2.79 2516 194578879 NP_001034528.2 1100 4.6e-117 distal-less [Tribolium castaneum]>gi|270011030|gb|EFA07478.1| distal-less [Tribolium castaneum] 194578878 NM_001039439.2 544 0 Tribolium castaneum distal-less (Dll), mRNA K18488 DLX2 homeobox protein DLX2 http://www.genome.jp/dbget-bin/www_bget?ko:K18488 P20009 476 4.3e-46 Homeotic protein distal-less OS=Drosophila melanogaster GN=Dll PE=2 SV=3 PF01787//PF05920//PF00046 Ilarvirus coat protein//Homeobox KN domain//Homeobox domain GO:0006355//GO:0006413 regulation of transcription, DNA-templated//translational initiation GO:0003723//GO:0003677 RNA binding//DNA binding GO:0019012 virion KOG0850 Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains Cluster-8309.2122 BP_3 3.71 0.32 853 642939856 XP_008196659.1 307 1.4e-25 PREDICTED: E3 ubiquitin-protein ligase LRSAM1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10641 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 http://www.genome.jp/dbget-bin/www_bget?ko:K10641 Q6UWE0 182 1.8e-12 E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens GN=LRSAM1 PE=1 SV=1 PF13516//PF13855//PF00560 Leucine Rich repeat//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.21221 BP_3 15.00 0.52 1695 268588965 ACZ06791.1 817 2.0e-84 eukaryotic translation initiation factor 5A [Scylla paramamosain] 268588964 FJ825623.1 926 0 Scylla paramamosain eukaryotic translation initiation factor 5A mRNA, complete cds K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 P62925 595 4.6e-60 Eukaryotic translation initiation factor 5A OS=Spodoptera frugiperda GN=eIF-5A PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0045901//GO:0045905//GO:0006448//GO:0006452 positive regulation of translational elongation//positive regulation of translational termination//regulation of translational elongation//translational frameshifting GO:0003746//GO:0003723//GO:0043022 translation elongation factor activity//RNA binding//ribosome binding GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-8309.21224 BP_3 78.29 1.03 3949 642935200 XP_966348.3 1554 1.6e-169 PREDICTED: kelch-like ECH-associated protein 1 isoform X1 [Tribolium castaneum] 642935203 XM_008201467.1 266 2.42661e-134 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 748 1.9e-77 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21226 BP_3 793.26 18.38 2372 189233695 XP_001812208.1 494 8.0e-47 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 369 1.0e-33 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF16367//PF08777//PF00010 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif//Helix-loop-helix DNA-binding domain -- -- GO:0003676//GO:0003723//GO:0046983 nucleic acid binding//RNA binding//protein dimerization activity -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.2123 BP_3 17.42 0.70 1490 134031943 NP_001076796.1 790 2.4e-81 cardioacceleratory peptide receptor 1 [Tribolium castaneum]>gi|126116538|gb|ABN79651.1| cardioactive peptide receptor 1 [Tribolium castaneum]>gi|270012688|gb|EFA09136.1| hypothetical protein TcasGA2_TC002216 [Tribolium castaneum]>gi|485836800|tpg|DAA64485.1| TPA_inf: CCAP-like G protein-coupled receptor 2 [Tribolium castaneum] -- -- -- -- -- K08376 NPSR1, GPR154 neuropeptide S receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08376 Q868T3 648 2.9e-66 Cardioacceleratory peptide receptor OS=Drosophila melanogaster GN=CCAP-R PE=2 SV=3 PF00001//PF02118 7 transmembrane receptor (rhodopsin family)//Srg family chemoreceptor GO:0007186//GO:0007606//GO:0007165//GO:0007187 G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//signal transduction//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0005000//GO:0004930//GO:0004888 vasopressin receptor activity//G-protein coupled receptor activity//transmembrane signaling receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.21230 BP_3 2.00 1.84 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09230 DNA fragmentation factor 40 kDa GO:0006309 apoptotic DNA fragmentation GO:0016787 hydrolase activity GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.21233 BP_3 3.00 0.61 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- -- -- Cluster-8309.21234 BP_3 2.00 0.62 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03400//PF08686 IS1 transposase//PLAC (protease and lacunin) domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0008233//GO:0004803 DNA binding//peptidase activity//transposase activity -- -- -- -- Cluster-8309.21237 BP_3 31.58 6.52 525 642935142 XP_008197905.1 284 4.0e-23 PREDICTED: putative acyl-activating enzyme 19 [Tribolium castaneum]>gi|270013381|gb|EFA09829.1| hypothetical protein TcasGA2_TC011976 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.21238 BP_3 34.28 1.30 1567 805815980 XP_012148641.1 218 5.4e-15 PREDICTED: uncharacterized protein LOC105663574 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21239 BP_3 98.55 0.93 5420 642937954 XP_008199143.1 2922 0.0e+00 PREDICTED: isoleucine--tRNA ligase, mitochondrial [Tribolium castaneum] 571578376 XM_006572314.1 45 2.38132e-11 PREDICTED: Apis mellifera isoleucyl-tRNA synthetase, mitochondrial-like (LOC726483), partial mRNA K01870 IARS, ileS isoleucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01870 Q4R646 1886 2.9e-209 Isoleucine--tRNA ligase, mitochondrial (Fragment) OS=Macaca fascicularis GN=IARS2 PE=2 SV=2 PF00133//PF09334//PF08264//PF10473//PF05746 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Anticodon-binding domain of tRNA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//DALR anticodon binding domain GO:0006560//GO:0006525//GO:0006418//GO:0006420 proline metabolic process//arginine metabolic process//tRNA aminoacylation for protein translation//arginyl-tRNA aminoacylation GO:0045502//GO:0008134//GO:0004814//GO:0005524//GO:0004812//GO:0000166//GO:0042803 dynein binding//transcription factor binding//arginine-tRNA ligase activity//ATP binding//aminoacyl-tRNA ligase activity//nucleotide binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex KOG0433 Isoleucyl-tRNA synthetase Cluster-8309.21240 BP_3 29.40 0.82 2013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21242 BP_3 55.00 2.39 1403 664818432 AIF73508.1 1407 6.4e-153 UV2 opsin, partial [Neogonodactylus oerstedii] 761599447 LC009300.1 43 7.82941e-11 Indolestes peregrinus RhSWa1 mRNA for opsin, short-wavelength sensitive type, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 O61303 1088 2.6e-117 Opsin, ultraviolet-sensitive OS=Apis mellifera GN=UVOP PE=1 SV=1 PF00001//PF02679 7 transmembrane receptor (rhodopsin family)//(2R)-phospho-3-sulfolactate synthase (ComA) GO:0019295//GO:0007186 coenzyme M biosynthetic process//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.21243 BP_3 21.00 1.62 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21244 BP_3 6.00 32.18 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21245 BP_3 31.00 0.31 5037 189237219 XP_001810222.1 4173 0.0e+00 PREDICTED: adenylate cyclase type 3 [Tribolium castaneum] 641655812 XM_001947691.3 187 2.55508e-90 PREDICTED: Acyrthosiphon pisum adenylate cyclase type 3 (LOC100163190), partial mRNA K08043 ADCY3 adenylate cyclase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08043 O60266 1830 8.5e-203 Adenylate cyclase type 3 OS=Homo sapiens GN=ADCY3 PE=2 SV=3 PF00211//PF04437//PF07701 Adenylate and Guanylate cyclase catalytic domain//RINT-1 / TIP-1 family//Heme NO binding associated GO:0006182//GO:0046039//GO:0006144//GO:0048193//GO:0035556//GO:0009190 cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process//Golgi vesicle transport//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0004383//GO:0016849 guanylate cyclase activity//phosphorus-oxygen lyase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.21246 BP_3 7.00 1.35 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21253 BP_3 24.44 0.37 3459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854//PF01139 P-11 zinc finger//tRNA-splicing ligase RtcB GO:0006396 RNA processing GO:0008452//GO:0003723//GO:0008270 RNA ligase activity//RNA binding//zinc ion binding -- -- -- -- Cluster-8309.21254 BP_3 14.78 3.61 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21256 BP_3 5989.54 61.20 5009 642940386 XP_008200540.1 2415 3.0e-269 PREDICTED: chitin deacetylase 5 isoform X1 [Tribolium castaneum] 827560342 XM_012695639.1 311 2.97677e-159 PREDICTED: Bombyx mori uncharacterized LOC101740429 (LOC101740429), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0005975//GO:0006807//GO:0006030 carbohydrate metabolic process//nitrogen compound metabolic process//chitin metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.21264 BP_3 77.18 1.82 2331 91080239 XP_972955.1 1621 1.6e-177 PREDICTED: TNF receptor-associated factor 6 [Tribolium castaneum]>gi|270006403|gb|EFA02851.1| TNF-receptor-associated factor 2 [Tribolium castaneum] -- -- -- -- -- K03175 TRAF6 TNF receptor-associated factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03175 A7XUJ6 378 9.2e-35 TNF receptor-associated factor 6 OS=Sus scrofa GN=TRAF6 PE=2 SV=1 PF17123//PF12678//PF14634//PF04564//PF00097//PF11789//PF02176//PF12861//PF13639//PF16685 RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//U-box domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//TRAF-type zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//zinc RING finger of MSL2 GO:0016567 protein ubiquitination GO:0008270//GO:0061630//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.21268 BP_3 92.55 4.65 1252 270016479 EFA12925.1 283 1.2e-22 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82596 175 1.7e-11 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21269 BP_3 30.60 1.46 1300 478256308 ENN76498.1 175 4.3e-10 hypothetical protein YQE_06950, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00690 145 5.3e-08 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21270 BP_3 3.00 0.34 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21271 BP_3 11.01 0.37 1714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21272 BP_3 9.99 0.75 934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21276 BP_3 62.68 1.13 2961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21277 BP_3 476.71 25.72 1185 91086847 XP_974260.1 1014 2.0e-107 PREDICTED: BSD domain-containing protein 1-B [Tribolium castaneum]>gi|270010460|gb|EFA06908.1| hypothetical protein TcasGA2_TC009857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BJ78 333 7.7e-30 BSD domain-containing protein 1 OS=Xenopus tropicalis GN=bsdc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2690 Uncharacterized conserved protein, contains BSD domain Cluster-8309.21279 BP_3 401.57 11.06 2041 642916474 XP_008191059.1 1647 1.4e-180 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270004236|gb|EFA00684.1| hypothetical protein TcasGA2_TC003561 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 829 4.1e-87 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 PF06423//PF04923 GWT1//Ninjurin GO:0042246//GO:0007155//GO:0006506 tissue regeneration//cell adhesion//GPI anchor biosynthetic process GO:0016746 transferase activity, transferring acyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG4683 Uncharacterized conserved protein Cluster-8309.21280 BP_3 142.43 4.44 1839 642916474 XP_008191059.1 1647 1.3e-180 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270004236|gb|EFA00684.1| hypothetical protein TcasGA2_TC003561 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 829 3.7e-87 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 PF04923//PF06423 Ninjurin//GWT1 GO:0006506//GO:0007155//GO:0042246 GPI anchor biosynthetic process//cell adhesion//tissue regeneration GO:0016746 transferase activity, transferring acyl groups GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG4683 Uncharacterized conserved protein Cluster-8309.21283 BP_3 53.00 0.98 2899 478254059 ENN74351.1 1545 1.3e-168 hypothetical protein YQE_09321, partial [Dendroctonus ponderosae]>gi|546672810|gb|ERL84566.1| hypothetical protein D910_01995 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01141 Gag polyprotein, inner coat protein p12 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.21284 BP_3 534.01 15.09 1997 642917151 XP_008191139.1 2389 1.2e-266 PREDICTED: F-box-like/WD repeat-containing protein TBL1XR1 [Tribolium castaneum]>gi|270004371|gb|EFA00819.1| hypothetical protein TcasGA2_TC003706 [Tribolium castaneum] 442624961 NM_057981.4 286 9.27654e-146 Drosophila melanogaster ebi (ebi), mRNA K04508 TBL1 transducin (beta)-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04508 Q8BHJ5 2046 3.0e-228 F-box-like/WD repeat-containing protein TBL1XR1 OS=Mus musculus GN=Tbl1xr1 PE=1 SV=1 PF01588//PF00400//PF00457//PF08513//PF04053 Putative tRNA binding domain//WD domain, G-beta repeat//Glycosyl hydrolases family 11//LisH//Coatomer WD associated region GO:0016192//GO:0006886//GO:0005975 vesicle-mediated transport//intracellular protein transport//carbohydrate metabolic process GO:0004553//GO:0005198//GO:0005515//GO:0000049 hydrolase activity, hydrolyzing O-glycosyl compounds//structural molecule activity//protein binding//tRNA binding GO:0030117 membrane coat KOG0273 Beta-transducin family (WD-40 repeat) protein Cluster-8309.21285 BP_3 228.83 4.77 2605 642938002 XP_008199166.1 582 5.5e-57 PREDICTED: uncharacterized protein LOC103314560 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 197 1.0e-13 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2129 BP_3 6.05 0.32 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21292 BP_3 214.20 1.88 5780 91077028 XP_967318.1 1305 1.8e-140 PREDICTED: moesin/ezrin/radixin homolog 1 [Tribolium castaneum]>gi|270002017|gb|EEZ98464.1| hypothetical protein TcasGA2_TC000955 [Tribolium castaneum] -- -- -- -- -- K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 988 4.2e-105 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF00887//PF04281//PF05531//PF02911//PF00551//PF00769 Acyl CoA binding protein//Mitochondrial import receptor subunit Tom22//Nucleopolyhedrovirus P10 protein//Formyl transferase, C-terminal domain//Formyl transferase//Ezrin/radixin/moesin family GO:0009058//GO:0006886 biosynthetic process//intracellular protein transport GO:0016742//GO:0008092//GO:0000062 hydroxymethyl-, formyl- and related transferase activity//cytoskeletal protein binding//fatty-acyl-CoA binding GO:0005741//GO:0005737//GO:0019028//GO:0019898 mitochondrial outer membrane//cytoplasm//viral capsid//extrinsic component of membrane KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.21295 BP_3 982.52 9.80 5124 478250642 ENN71134.1 2858 0.0e+00 hypothetical protein YQE_12065, partial [Dendroctonus ponderosae]>gi|546674775|gb|ERL86072.1| hypothetical protein D910_03486 [Dendroctonus ponderosae] -- -- -- -- -- K03028 PSMD2, RPN1 26S proteasome regulatory subunit N1 http://www.genome.jp/dbget-bin/www_bget?ko:K03028 Q13200 2129 1.8e-237 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 PF12937//PF00328 F-box-like//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0003993 protein binding//acid phosphatase activity -- -- KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2 Cluster-8309.21298 BP_3 6.26 0.31 1281 662207355 XP_008477177.1 212 2.2e-14 PREDICTED: hemicentin-2-like, partial [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21305 BP_3 118.10 15.50 659 166851830 NP_001107779.1 691 3.2e-70 bursicon precursor [Tribolium castaneum]>gi|74325216|gb|ABA03053.1| bursicon [Tribolium castaneum]>gi|270008186|gb|EFA04634.1| bursicon [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VD83 578 1.7e-58 Bursicon OS=Drosophila melanogaster GN=Burs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21307 BP_3 852.57 9.48 4628 642925855 XP_008190573.1 1955 6.1e-216 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K06171 NCSTN nicastrin http://www.genome.jp/dbget-bin/www_bget?ko:K06171 Q9VC27 1091 3.8e-117 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF00328//PF05450 Histidine phosphatase superfamily (branch 2)//Nicastrin GO:0016485//GO:0006771//GO:0019497 protein processing//riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane KOG2657 Transmembrane glycoprotein nicastrin Cluster-8309.21308 BP_3 130.67 7.08 1181 642936663 XP_008198528.1 758 9.8e-78 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10859 ALKBH2 alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10859 Q6P6J4 582 1.0e-58 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 OS=Mus musculus GN=Alkbh2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21310 BP_3 365.00 6.78 2888 642937884 XP_008200340.1 2011 1.2e-222 PREDICTED: F-box/LRR-repeat protein 6 isoform X1 [Tribolium castaneum]>gi|642937886|ref|XP_008200341.1| PREDICTED: F-box/LRR-repeat protein 6 isoform X1 [Tribolium castaneum]>gi|642937890|ref|XP_008200344.1| PREDICTED: F-box/LRR-repeat protein 6 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10272 FBXL6 F-box and leucine-rich repeat protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10272 Q8N531 528 4.6e-52 F-box/LRR-repeat protein 6 OS=Homo sapiens GN=FBXL6 PE=2 SV=1 PF13855//PF12937//PF00646 Leucine rich repeat//F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.21311 BP_3 1.00 27.20 219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21313 BP_3 10.42 0.32 1879 91078940 XP_973987.1 899 6.9e-94 PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|642916209|ref|XP_008190931.1| PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|270003691|gb|EFA00139.1| hypothetical protein TcasGA2_TC002960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWP6 452 1.9e-43 Motile sperm domain-containing protein 2 OS=Mus musculus GN=Mospd2 PE=1 SV=2 -- -- -- -- GO:0005198 structural molecule activity -- -- KOG1471 Phosphatidylinositol transfer protein SEC14 and related proteins Cluster-8309.21314 BP_3 17.14 0.59 1687 728417366 AIY68341.1 1141 5.4e-122 putative pheromone esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 611 6.4e-62 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.21315 BP_3 228.94 5.07 2469 189241024 XP_970684.2 1458 1.4e-158 PREDICTED: negative elongation factor A isoform X2 [Tribolium castaneum] 642935140 XM_965591.3 295 1.14271e-150 PREDICTED: Tribolium castaneum negative elongation factor A (LOC659266), transcript variant X2, mRNA K15179 WHSC2, NELFA negative elongation factor A http://www.genome.jp/dbget-bin/www_bget?ko:K15179 Q86NP2 1083 1.7e-116 Negative elongation factor A OS=Drosophila melanogaster GN=Nelf-A PE=1 SV=2 PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.21316 BP_3 82.06 1.52 2892 189241024 XP_970684.2 1019 1.3e-107 PREDICTED: negative elongation factor A isoform X2 [Tribolium castaneum] 642935140 XM_965591.3 241 1.39853e-120 PREDICTED: Tribolium castaneum negative elongation factor A (LOC659266), transcript variant X2, mRNA K15179 WHSC2, NELFA negative elongation factor A http://www.genome.jp/dbget-bin/www_bget?ko:K15179 Q86NP2 826 1.3e-86 Negative elongation factor A OS=Drosophila melanogaster GN=Nelf-A PE=1 SV=2 PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.21318 BP_3 10.94 0.97 838 270004865 EFA01313.1 851 1.1e-88 hypothetical protein TcasGA2_TC003245 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 463 4.6e-45 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF05481//PF17076//PF02793 Mycobacterium 19 kDa lipoprotein antigen//SBE2, cell-qall formation//Hormone receptor domain GO:0031505//GO:0007186 fungal-type cell wall organization//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.21320 BP_3 13.00 0.84 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21322 BP_3 118.64 1.13 5342 642919913 XP_008192122.1 1315 1.1e-141 PREDICTED: transcription factor SOX-13 [Tribolium castaneum] 759081689 XM_011352406.1 129 4.73301e-58 PREDICTED: Cerapachys biroi transcription factor SOX-5 (LOC105287028), mRNA K09269 SOX5_6_13 transcription factor SOX5/6/13 (SOX group D) http://www.genome.jp/dbget-bin/www_bget?ko:K09269 P35712 523 3.2e-51 Transcription factor SOX-6 OS=Homo sapiens GN=SOX6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0528 HMG-box transcription factor SOX5 Cluster-8309.21328 BP_3 1.01 0.39 417 506965688 AGM32196.1 227 1.3e-16 transmembrane emp24 domain-containing protein 2 precursor [Coptotermes formosanus] -- -- -- -- -- -- -- -- -- A7SXK3 206 1.4e-15 Transmembrane emp24 domain-containing protein OS=Nematostella vectensis GN=v1g194562 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1692 Putative cargo transport protein EMP24 (p24 protein family) Cluster-8309.21329 BP_3 33.00 1.25 1567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2133 BP_3 44.00 7.79 564 642918073 XP_008193892.1 179 6.4e-11 PREDICTED: uncharacterized protein LOC103313153 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08287 Spc19 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0005876 DASH complex//spindle microtubule -- -- Cluster-8309.21330 BP_3 35.11 0.57 3270 642933809 XP_008197363.1 653 4.1e-65 PREDICTED: G-protein coupled receptor 143 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70259 158 4.2e-09 G-protein coupled receptor 143 OS=Mus musculus GN=Gpr143 PE=2 SV=1 PF01534//PF02101 Frizzled/Smoothened family membrane region//Ocular albinism type 1 protein GO:0007166 cell surface receptor signaling pathway -- -- GO:0016020 membrane -- -- Cluster-8309.21331 BP_3 6.00 2.35 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.21332 BP_3 63.64 1.25 2751 642911585 XP_967231.3 2292 3.0e-255 PREDICTED: glutaminase kidney isoform, mitochondrial isoform X2 [Tribolium castaneum] 766928101 XM_011497776.1 158 1.83286e-74 PREDICTED: Ceratosolen solmsi marchali glutaminase kidney isoform, mitochondrial (LOC105360775), mRNA K01425 glsA, GLS glutaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01425 P13264 1459 4.8e-160 Glutaminase kidney isoform, mitochondrial OS=Rattus norvegicus GN=Gls PE=1 SV=2 PF04960//PF13606//PF00023 Glutaminase//Ankyrin repeat//Ankyrin repeat GO:0006541 glutamine metabolic process GO:0004359//GO:0005515 glutaminase activity//protein binding -- -- KOG0506 Glutaminase (contains ankyrin repeat) Cluster-8309.21335 BP_3 96.00 2.13 2461 91079258 XP_971676.1 1749 2.5e-192 PREDICTED: homeobox protein caupolican [Tribolium castaneum] 642916739 XM_966583.2 477 0 PREDICTED: Tribolium castaneum homeobox protein caupolican (LOC660345), mRNA -- -- -- -- P54269 540 1.6e-53 Homeobox protein caupolican OS=Drosophila melanogaster GN=caup PE=2 SV=2 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.21343 BP_3 22.00 1.87 859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21344 BP_3 5.00 0.32 1044 91087535 XP_970133.1 317 1.2e-26 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] -- -- -- -- -- K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 185 9.8e-13 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 -- -- GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.21345 BP_3 3.00 0.42 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21346 BP_3 24.66 2.61 747 189236834 XP_001812569.1 689 6.2e-70 PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|270005053|gb|EFA01501.1| hypothetical protein TcasGA2_TC007057 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.21347 BP_3 50.80 0.32 7961 641658099 XP_008180596.1 937 1.2e-97 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 642920823 XM_008194352.1 45 3.50365e-11 PREDICTED: Tribolium castaneum transcription factor SPT20 homolog (LOC661459), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 886 3.9e-93 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF13912//PF12090//PF04810//PF00412//PF12833//PF02892//PF16622//PF00096 Zinc-finger double domain//C2H2-type zinc finger//Spt20 family//Sec23/Sec24 zinc finger//LIM domain//Helix-turn-helix domain//BED zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type GO:0006355//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0003712//GO:0043565//GO:0003700//GO:0046872//GO:0003677 zinc ion binding//transcription cofactor activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//DNA binding GO:0030127//GO:0005667//GO:0000124 COPII vesicle coat//transcription factor complex//SAGA complex -- -- Cluster-8309.2135 BP_3 1.00 0.38 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21350 BP_3 24.13 0.32 3943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21352 BP_3 115.59 0.74 7792 607361355 EZA55644.1 794 4.3e-81 hypothetical protein X777_04316 [Cerapachys biroi] 795019032 XM_012004052.1 63 3.38075e-21 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556938 (LOC105556938), mRNA -- -- -- -- -- -- -- -- PF03175//PF03184//PF00982 DNA polymerase type B, organellar and viral//DDE superfamily endonuclease//Glycosyltransferase family 20 GO:0005992//GO:0006260 trehalose biosynthetic process//DNA replication GO:0003887//GO:0003677//GO:0003824//GO:0003676//GO:0008408//GO:0000166 DNA-directed DNA polymerase activity//DNA binding//catalytic activity//nucleic acid binding//3'-5' exonuclease activity//nucleotide binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.21354 BP_3 9.41 1.09 707 751241840 XP_011175043.1 271 1.7e-21 PREDICTED: uncharacterized protein LOC105207312, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21355 BP_3 30.51 7.12 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21358 BP_3 2.00 2.64 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21360 BP_3 54.83 0.82 3534 91090524 XP_970076.1 662 4.0e-66 PREDICTED: coenzyme Q-binding protein COQ10 homolog B, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18588 COQ10 coenzyme Q-binding protein COQ10 http://www.genome.jp/dbget-bin/www_bget?ko:K18588 Q6DFA6 448 1.1e-42 Coenzyme Q-binding protein COQ10 homolog A, mitochondrial OS=Xenopus laevis GN=coq10b-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3177 Oligoketide cyclase/lipid transport protein Cluster-8309.21364 BP_3 13.52 0.31 2379 91080493 XP_970962.1 1370 2.1e-148 PREDICTED: bestrophin-3 [Tribolium castaneum]>gi|270005768|gb|EFA02216.1| hypothetical protein TcasGA2_TC007875 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8BGM5 883 2.6e-93 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.21369 BP_3 81.56 0.93 4526 270012558 EFA09006.1 1521 1.3e-165 hypothetical protein TcasGA2_TC006714 [Tribolium castaneum] 850480667 CP011888.1 37 5.56076e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 822 5.8e-86 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF00268//PF09061 Ribonucleotide reductase, small chain//Stirrup GO:0055114//GO:0009186 oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.21370 BP_3 164.00 4.45 2070 189241108 XP_972242.2 1446 2.9e-157 PREDICTED: U3 small nucleolar ribonucleoprotein protein IMP4 isoform X1 [Tribolium castaneum]>gi|270013895|gb|EFA10343.1| hypothetical protein TcasGA2_TC012561 [Tribolium castaneum] -- -- -- -- -- K14561 IMP4 U3 small nucleolar ribonucleoprotein protein IMP4 http://www.genome.jp/dbget-bin/www_bget?ko:K14561 Q0VD01 906 4.9e-96 U3 small nucleolar ribonucleoprotein protein IMP4 OS=Bos taurus GN=IMP4 PE=2 SV=1 PF09360 Iron-binding zinc finger CDGSH type -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG2781 U3 small nucleolar ribonucleoprotein (snoRNP) component Cluster-8309.21377 BP_3 2.00 1.30 362 195030306 XP_001988009.1 200 1.5e-13 GH10934 [Drosophila grimshawi]>gi|193904009|gb|EDW02876.1| GH10934 [Drosophila grimshawi] -- -- -- -- -- -- -- -- -- D2WKD9 164 9.3e-11 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00608//PF00106 Adenoviral fibre protein (repeat/shaft region)//short chain dehydrogenase GO:0007155//GO:0008152//GO:0009405//GO:0019062 cell adhesion//metabolic process//pathogenesis//virion attachment to host cell GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.2138 BP_3 76.56 4.12 1187 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21380 BP_3 120.09 1.49 4180 642934494 XP_008197688.1 4481 0.0e+00 PREDICTED: proteasome-associated protein ECM29 homolog [Tribolium castaneum] -- -- -- -- -- K11886 ECM29 proteasome component ECM29 http://www.genome.jp/dbget-bin/www_bget?ko:K11886 Q9V677 2044 1.1e-227 Proteasome-associated protein ECM29 homolog OS=Drosophila melanogaster GN=CG8858 PE=1 SV=1 PF05997//PF08064//PF02985 Nucleolar protein,Nop52//UME (NUC010) domain//HEAT repeat GO:0006364//GO:0009069//GO:0016310 rRNA processing//serine family amino acid metabolic process//phosphorylation GO:0004674//GO:0005515 protein serine/threonine kinase activity//protein binding GO:0030688 preribosome, small subunit precursor KOG0915 Uncharacterized conserved protein Cluster-8309.21382 BP_3 220.35 2.60 4382 642911299 XP_008199361.1 2649 1.9e-296 PREDICTED: forkhead box protein P1-like isoform X2 [Tribolium castaneum] 642911298 XM_008201139.1 419 0 PREDICTED: Tribolium castaneum forkhead box protein P1-like (LOC657917), transcript variant X2, mRNA K09409 FOXP forkhead box protein P http://www.genome.jp/dbget-bin/www_bget?ko:K09409 Q5W1J5 874 5.3e-92 Forkhead box protein P1 OS=Xenopus laevis GN=foxp1 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG4385 Predicted forkhead transcription factor Cluster-8309.21385 BP_3 1605.52 69.32 1408 291170322 ADD82417.1 321 5.5e-27 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27018 133 1.4e-06 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.21386 BP_3 18157.03 1249.76 992 758213802 AJO62214.1 422 7.5e-39 chemosensory protein CSP8 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q27377 275 3.4e-23 Putative odorant-binding protein A10 OS=Drosophila melanogaster GN=a10 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21387 BP_3 20.00 4.26 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21388 BP_3 23.47 0.54 2402 91078844 XP_971675.1 341 4.5e-29 PREDICTED: leucine-rich repeat-containing protein 59 [Tribolium castaneum]>gi|270003717|gb|EFA00165.1| hypothetical protein TcasGA2_TC002987 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NWG1 202 2.4e-14 Leucine-rich repeat-containing protein 59 OS=Danio rerio GN=lrrc59 PE=2 SV=1 PF07836 DmpG-like communication domain GO:0019439 aromatic compound catabolic process GO:0016833 oxo-acid-lyase activity -- -- -- -- Cluster-8309.2139 BP_3 23.69 0.54 2419 270003199 EEZ99646.1 169 4.0e-09 hypothetical protein TcasGA2_TC002403 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.21394 BP_3 15.00 2.43 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.21403 BP_3 174.75 3.18 2942 91085713 XP_972970.1 1384 6.3e-150 PREDICTED: cyclin-H [Tribolium castaneum]>gi|270010021|gb|EFA06469.1| hypothetical protein TcasGA2_TC009354 [Tribolium castaneum] 51776239 AK174982.1 53 4.59021e-16 Ciona intestinalis cDNA, clone:citb089b03, full insert sequence K06634 CCNH cyclin H http://www.genome.jp/dbget-bin/www_bget?ko:K06634 Q9R1A0 581 3.3e-58 Cyclin-H OS=Rattus norvegicus GN=Ccnh PE=2 SV=2 PF05920//PF06687//PF00382//PF01857//PF00046//PF02984 Homeobox KN domain//SUR7/PalI family//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain//Homeobox domain//Cyclin, C-terminal domain GO:0006355//GO:0000079//GO:0051726 regulation of transcription, DNA-templated//regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of cell cycle GO:0019901//GO:0017025//GO:0003677 protein kinase binding//TBP-class protein binding//DNA binding GO:0005634//GO:0005886//GO:0005675 nucleus//plasma membrane//holo TFIIH complex KOG2496 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit Cluster-8309.21405 BP_3 44.76 0.36 6365 642937652 XP_966876.3 696 8.1e-70 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17010 373 9.5e-34 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF00096//PF13465//PF00130//PF02150//PF06816//PF09505//PF04196 Zinc finger, C2H2 type//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//RNA polymerases M/15 Kd subunit//NOTCH protein//Dimethylamine methyltransferase (Dimeth_PyL)//Bunyavirus RNA dependent RNA polymerase GO:0006206//GO:0030154//GO:0035556//GO:0019079//GO:0015948//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//cell differentiation//intracellular signal transduction//viral genome replication//methanogenesis//transcription, DNA-templated//purine nucleobase metabolic process GO:0003968//GO:0008168//GO:0046872//GO:0003677//GO:0003899 RNA-directed RNA polymerase activity//methyltransferase activity//metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0031379//GO:0016021 nucleolus//RNA-directed RNA polymerase complex//integral component of membrane -- -- Cluster-8309.21407 BP_3 19.63 0.88 1367 642921217 XP_008192768.1 482 1.1e-45 PREDICTED: uncharacterized protein LOC656848 isoform X1 [Tribolium castaneum] 642921216 XM_008194546.1 98 2.03149e-41 PREDICTED: Tribolium castaneum uncharacterized LOC656848 (LOC656848), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF02950//PF02819//PF05039 Conotoxin//Spider toxin//Agouti protein GO:0006810//GO:0009405//GO:0009755 transport//pathogenesis//hormone-mediated signaling pathway GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21408 BP_3 196.37 9.03 1340 642921219 XP_968442.2 439 1.1e-40 PREDICTED: uncharacterized protein LOC656848 isoform X2 [Tribolium castaneum]>gi|270005083|gb|EFA01531.1| hypothetical protein TcasGA2_TC007091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02950//PF02819//PF00695//PF05039 Conotoxin//Spider toxin//Major surface antigen from hepadnavirus//Agouti protein GO:0009405//GO:0016032//GO:0009755//GO:0006810 pathogenesis//viral process//hormone-mediated signaling pathway//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21409 BP_3 64.16 0.60 5456 642933323 XP_008197368.1 1156 3.2e-123 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 668 5.1e-68 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF02166//PF03644 Androgen receptor//Glycosyl hydrolase family 85 GO:0030521//GO:0006355//GO:0007165 androgen receptor signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0033925//GO:0005496//GO:0004882//GO:0003677 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity//steroid binding//androgen receptor activity//DNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG2331 Predicted glycosylhydrolase Cluster-8309.21410 BP_3 8899.17 405.32 1350 91083833 XP_973697.1 679 1.6e-68 PREDICTED: endocuticle structural glycoprotein SgAbd-8 [Tribolium castaneum]>gi|270006770|gb|EFA03218.1| hypothetical protein TcasGA2_TC013138 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 278 2.1e-23 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.21411 BP_3 22.85 0.73 1796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21412 BP_3 1.00 0.33 436 646696995 KDR08934.1 255 7.6e-20 hypothetical protein L798_01471 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21413 BP_3 259.33 5.92 2403 270009092 EFA05540.1 3503 0.0e+00 hypothetical protein TcasGA2_TC015727 [Tribolium castaneum] 642926476 XM_008193752.1 368 0 PREDICTED: Tribolium castaneum protein suppressor of forked (LOC661644), mRNA K14408 CSTF3, RNA14 cleavage stimulation factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14408 P25991 2430 1.1e-272 Protein suppressor of forked OS=Drosophila melanogaster GN=su(f) PE=1 SV=2 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG1914 mRNA cleavage and polyadenylation factor I complex, subunit RNA14 Cluster-8309.21417 BP_3 154.63 4.96 1793 642916004 XP_008190853.1 1871 1.3e-206 PREDICTED: probable ATP-dependent RNA helicase DDX52 [Tribolium castaneum] -- -- -- -- -- K14779 DDX52, ROK1 ATP-dependent RNA helicase DDX52/ROK1 http://www.genome.jp/dbget-bin/www_bget?ko:K14779 A5D7C1 1299 1.1e-141 Probable ATP-dependent RNA helicase DDX52 OS=Bos taurus GN=DDX52 PE=2 SV=1 PF00270//PF02602//PF12689//PF04851 DEAD/DEAH box helicase//Uroporphyrinogen-III synthase HemD//Acid Phosphatase//Type III restriction enzyme, res subunit GO:0015994//GO:0033014//GO:0006783 chlorophyll metabolic process//tetrapyrrole biosynthetic process//heme biosynthetic process GO:0016791//GO:0003677//GO:0016787//GO:0005524//GO:0004852//GO:0003676 phosphatase activity//DNA binding//hydrolase activity//ATP binding//uroporphyrinogen-III synthase activity//nucleic acid binding -- -- KOG0344 ATP-dependent RNA helicase Cluster-8309.21418 BP_3 41.00 8.54 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21419 BP_3 59.37 1.84 1843 270003649 EFA00097.1 1109 3.0e-118 hypothetical protein TcasGA2_TC002912 [Tribolium castaneum] -- -- -- -- -- K14779 DDX52, ROK1 ATP-dependent RNA helicase DDX52/ROK1 http://www.genome.jp/dbget-bin/www_bget?ko:K14779 A5D7C1 717 3.6e-74 Probable ATP-dependent RNA helicase DDX52 OS=Bos taurus GN=DDX52 PE=2 SV=1 PF04851//PF00270//PF07652 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Flavivirus DEAD domain GO:0019079 viral genome replication GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0008026 ATP binding//DNA binding//hydrolase activity//nucleic acid binding//ATP-dependent helicase activity -- -- KOG0344 ATP-dependent RNA helicase Cluster-8309.21421 BP_3 190.52 6.74 1655 642932331 XP_008197068.1 394 2.2e-35 PREDICTED: uncharacterized protein LOC103314051 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07947//PF06624//PF01284 YhhN-like protein//Ribosome associated membrane protein RAMP4//Membrane-associating domain -- -- -- -- GO:0005783//GO:0016021//GO:0016020 endoplasmic reticulum//integral component of membrane//membrane -- -- Cluster-8309.21422 BP_3 713.78 18.52 2149 270006196 EFA02644.1 460 6.4e-43 hypothetical protein TcasGA2_TC008365 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21425 BP_3 141.58 0.71 9925 642935750 XP_008198157.1 2472 1.5e-275 PREDICTED: rotatin [Tribolium castaneum] -- -- -- -- -- K14301 NUP107, NUP84 nuclear pore complex protein Nup107 http://www.genome.jp/dbget-bin/www_bget?ko:K14301 Q8BH74 735 1.6e-75 Nuclear pore complex protein Nup107 OS=Mus musculus GN=Nup107 PE=2 SV=1 PF04121 Nuclear pore protein 84 / 107 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1964 Nuclear pore complex, rNup107 component (sc Nup84) Cluster-8309.21426 BP_3 1.00 1.89 299 642939494 XP_008190865.1 157 1.2e-08 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005488 binding -- -- -- -- Cluster-8309.21431 BP_3 388.91 12.76 1761 332374188 AEE62235.1 643 3.1e-64 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08666 KLK4, PRSS17 kallikrein 4 (prostase, enamel matrix, prostate) http://www.genome.jp/dbget-bin/www_bget?ko:K08666 P36178 441 3.4e-42 Chymotrypsin BII OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21434 BP_3 122.74 2.72 2468 91090986 XP_974863.1 2212 5.1e-246 PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936123|ref|XP_008198309.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936125|ref|XP_008198310.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|270013188|gb|EFA09636.1| hypothetical protein TcasGA2_TC011759 [Tribolium castaneum] -- -- -- -- -- K11862 ZRANB1, TRABID ubiquitin thioesterase ZRANB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11862 Q9VH90 1726 4.8e-191 Ubiquitin thioesterase trabid OS=Drosophila melanogaster GN=trbd PE=1 SV=1 -- -- -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG4345 NF-kappa B regulator AP20/Cezanne Cluster-8309.21435 BP_3 78.30 0.57 6932 642910859 XP_008193438.1 1525 6.6e-166 PREDICTED: mitogen-activated protein kinase 14B-like [Tribolium castaneum] 749732005 XM_011139608.1 229 1.58152e-113 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1333 5.0e-145 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF01762//PF07714//PF06293//PF02434//PF00069//PF13414 Galactosyltransferase//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Fringe-like//Protein kinase domain//TPR repeat GO:0006468//GO:0006486 protein phosphorylation//protein glycosylation GO:0005524//GO:0016757//GO:0005515//GO:0016773//GO:0008378//GO:0004672 ATP binding//transferase activity, transferring glycosyl groups//protein binding//phosphotransferase activity, alcohol group as acceptor//galactosyltransferase activity//protein kinase activity GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.21436 BP_3 32.12 0.62 2771 189237765 XP_001812950.1 1454 4.5e-158 PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|642924439|ref|XP_008194298.1| PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|270006791|gb|EFA03239.1| hypothetical protein TcasGA2_TC013171 [Tribolium castaneum] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 O01735 1022 2.3e-109 Uncharacterized MFS-type transporter C09D4.1 OS=Caenorhabditis elegans GN=C09D4.1 PE=3 SV=2 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.21437 BP_3 2.00 0.87 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21438 BP_3 209.65 4.65 2463 642912504 XP_008200894.1 773 3.7e-79 PREDICTED: F-box/WD repeat-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P57775 425 3.4e-40 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21441 BP_3 10.18 0.40 1525 270003307 EEZ99754.1 394 2.0e-35 hypothetical protein TcasGA2_TC002523 [Tribolium castaneum] 642918185 XM_008193179.1 134 2.20906e-61 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21442 BP_3 176.27 2.95 3174 642917459 XP_008191209.1 3060 0.0e+00 PREDICTED: ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17635 RGL1, RGL ral guanine nucleotide dissociation stimulator-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17635 Q9NZL6 971 2.2e-103 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00788//PF00617 Ras association (RalGDS/AF-6) domain//RasGEF domain GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.21443 BP_3 126.81 1.66 3976 642919951 XP_008192141.1 1040 6.6e-110 PREDICTED: protein ovo isoform X3 [Tribolium castaneum] 524990254 XM_005042954.1 45 1.74264e-11 PREDICTED: Ficedula albicollis ovo-like 2 (Drosophila) (OVOL2), mRNA K09216 OVOL ovo http://www.genome.jp/dbget-bin/www_bget?ko:K09216 P51521 760 7.9e-79 Protein ovo OS=Drosophila melanogaster GN=ovo PE=1 SV=2 PF16622//PF05191//PF01363//PF06397//PF01096//PF00096//PF13465 zinc-finger C2H2-type//Adenylate kinase, active site lid//FYVE zinc finger//Desulfoferrodoxin, N-terminal domain//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006144//GO:0046034//GO:0006351 purine nucleobase metabolic process//ATP metabolic process//transcription, DNA-templated GO:0046872//GO:0004017//GO:0005506//GO:0008270//GO:0003676 metal ion binding//adenylate kinase activity//iron ion binding//zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.21444 BP_3 546.66 27.87 1237 91091334 XP_971825.1 811 7.3e-84 PREDICTED: signal recognition particle receptor subunit beta [Tribolium castaneum]>gi|270014143|gb|EFA10591.1| hypothetical protein TcasGA2_TC012850 [Tribolium castaneum] -- -- -- -- -- K12272 SRPRB, SRP102 signal recognition particle receptor subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12272 Q9Y5M8 470 1.0e-45 Signal recognition particle receptor subunit beta OS=Homo sapiens GN=SRPRB PE=1 SV=3 PF01926//PF08477//PF02421//PF04670//PF00025 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily) Cluster-8309.21445 BP_3 456.00 17.61 1540 642916382 XP_008190997.1 1144 2.2e-122 PREDICTED: GPN-loop GTPase 2 [Tribolium castaneum]>gi|270003652|gb|EFA00100.1| hypothetical protein TcasGA2_TC002915 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q6PUR6 716 3.9e-74 GPN-loop GTPase 2 OS=Danio rerio GN=gpn2 PE=2 SV=1 PF01926//PF03266//PF07728//PF00448 50S ribosome-binding GTPase//NTPase//AAA domain (dynein-related subfamily)//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0016887//GO:0098519//GO:0005524//GO:0005525//GO:0000166 ATPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//GTP binding//nucleotide binding -- -- KOG1533 Predicted GTPase Cluster-8309.21446 BP_3 2.00 1.01 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21447 BP_3 22.47 0.43 2809 642924747 XP_008194424.1 3117 0.0e+00 PREDICTED: tyrosine-protein kinase PR2 isoform X3 [Tribolium castaneum] 462376521 APGK01023661.1 50 2.03788e-14 Dendroctonus ponderosae Seq01023671, whole genome shotgun sequence -- -- -- -- Q9I7F7 1702 3.3e-188 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF10598//PF07714//PF14604//PF00018//PF00069 RNA recognition motif of the spliceosomal PrP8//Protein tyrosine kinase//Variant SH3 domain//SH3 domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0003723 protein binding//protein kinase activity//ATP binding//RNA binding -- -- KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.21448 BP_3 340.00 18.02 1201 270010058 EFA06506.1 460 3.6e-43 hypothetical protein TcasGA2_TC009405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06839//PF02537 GRF zinc finger//CrcB-like protein, Camphor Resistance (CrcB) -- -- GO:0008270 zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.21449 BP_3 661.68 8.45 4066 642910366 XP_008200294.1 3938 0.0e+00 PREDICTED: myosin-IB [Tribolium castaneum]>gi|270014945|gb|EFA11393.1| hypothetical protein TcasGA2_TC011553 [Tribolium castaneum] 637314166 XM_008113233.1 58 1.05769e-18 PREDICTED: Anolis carolinensis myosin ID (myo1d), transcript variant X2, mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23979 3146 0.0e+00 Myosin-IB OS=Drosophila melanogaster GN=Myo61F PE=1 SV=3 PF00437//PF00485//PF06017//PF00612//PF06414//PF00063//PF07475 Type II/IV secretion system protein//Phosphoribulokinase / Uridine kinase family//Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Zeta toxin//Myosin head (motor domain)//HPr Serine kinase C-terminal domain GO:0000160//GO:0008152//GO:0006810//GO:0006109//GO:0016310 phosphorelay signal transduction system//metabolic process//transport//regulation of carbohydrate metabolic process//phosphorylation GO:0005524//GO:0000155//GO:0005515//GO:0016301//GO:0003774//GO:0004672 ATP binding//phosphorelay sensor kinase activity//protein binding//kinase activity//motor activity//protein kinase activity GO:0016459//GO:0009365 myosin complex//protein histidine kinase complex KOG0164 Myosin class I heavy chain Cluster-8309.21452 BP_3 21.00 0.56 2102 332375851 AEE63066.1 1355 1.0e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 Q9UB00 931 6.2e-99 Putative glucosylceramidase 4 OS=Caenorhabditis elegans GN=gba-4 PE=3 SV=2 PF02055//PF02057 O-Glycosyl hydrolase family 30//Glycosyl hydrolase family 59 GO:0006683//GO:0006807//GO:0006665//GO:0005975//GO:0006687 galactosylceramide catabolic process//nitrogen compound metabolic process//sphingolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process GO:0004336//GO:0004348 galactosylceramidase activity//glucosylceramidase activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.21456 BP_3 32.00 4.28 652 642913920 XP_008201214.1 361 5.8e-32 PREDICTED: uncharacterized protein LOC103315121 [Tribolium castaneum]>gi|270001641|gb|EEZ98088.1| hypothetical protein TcasGA2_TC000501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21457 BP_3 23.62 1.35 1138 642919030 XP_008191704.1 542 1.0e-52 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 194893660 XM_001977880.1 36 4.9207e-07 Drosophila erecta GG19306 (Dere\GG19306), mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 -- -- -- -- PF12920 TcdA/TcdB pore forming domain GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.21458 BP_3 338.51 17.98 1199 642928451 XP_972332.2 1470 2.7e-160 PREDICTED: UPF0160 protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58DG1 869 5.5e-92 UPF0160 protein MYG1, mitochondrial OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2948 Predicted metal-binding protein Cluster-8309.21461 BP_3 468.25 9.65 2630 91085213 XP_972338.1 2466 1.9e-275 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009080|gb|EFA05528.1| hypothetical protein TcasGA2_TC015715 [Tribolium castaneum] 817051486 XM_012395873.1 121 6.48364e-54 PREDICTED: Athalia rosae glucose dehydrogenase [FAD, quinone] (LOC105683336), mRNA -- -- -- -- P18172 1064 2.9e-114 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05834//PF00732//PF07992//PF01266//PF05199 Lycopene cyclase protein//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase GO:0006563//GO:0006066//GO:0006566//GO:0016117//GO:0006544//GO:0055114 L-serine metabolic process//alcohol metabolic process//threonine metabolic process//carotenoid biosynthetic process//glycine metabolic process//oxidation-reduction process GO:0016614//GO:0016705//GO:0016491//GO:0008812//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.21463 BP_3 26.08 0.54 2628 91090216 XP_968004.1 1600 5.0e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 6.5e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008146//GO:0008476 sulfotransferase activity//protein-tyrosine sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.21464 BP_3 4.12 0.40 786 642919713 XP_008192033.1 371 4.9e-33 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 266 3.0e-22 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150//PF01554 GDA1/CD39 (nucleoside phosphatase) family//MatE GO:0055085//GO:0015893//GO:0006810//GO:0006855 transmembrane transport//drug transport//transport//drug transmembrane transport GO:0016787//GO:0015297//GO:0015238 hydrolase activity//antiporter activity//drug transmembrane transporter activity GO:0016020 membrane KOG1385 Nucleoside phosphatase Cluster-8309.21468 BP_3 200.00 6.16 1856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21469 BP_3 285.50 9.34 1765 91089769 XP_967094.1 1002 7.4e-106 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 B4MYA4 520 2.4e-51 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.2147 BP_3 3.00 0.70 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21470 BP_3 647.43 4.99 6543 675381743 KFM74645.1 366 1.5e-31 Zinc finger protein 729, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q05481 327 2.1e-28 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF00096//PF13912//PF04810//PF02892//PF00412//PF06305//PF13465//PF07975 Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//LIM domain//Protein of unknown function (DUF1049)//Zinc-finger double domain//TFIIH C1-like domain GO:0006886//GO:0006888//GO:0006281 intracellular protein transport//ER to Golgi vesicle-mediated transport//DNA repair GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005887//GO:0030127 integral component of plasma membrane//COPII vesicle coat -- -- Cluster-8309.21471 BP_3 34.81 0.87 2218 190702371 ACE75264.1 2131 1.1e-236 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- P10582 132 2.9e-06 DNA polymerase OS=Zea mays PE=3 SV=1 PF08509//PF03175 Adenylate cyclase G-alpha binding domain//DNA polymerase type B, organellar and viral GO:0006171//GO:0006144//GO:0006260 cAMP biosynthetic process//purine nucleobase metabolic process//DNA replication GO:0003677//GO:0003887//GO:0008408//GO:0000166//GO:0004016//GO:0000287 DNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//nucleotide binding//adenylate cyclase activity//magnesium ion binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.21474 BP_3 129.43 0.73 8858 642912924 XP_008201308.1 3929 0.0e+00 PREDICTED: eye-specific diacylglycerol kinase isoform X3 [Tribolium castaneum] 194890784 XM_001977354.1 96 1.7392e-39 Drosophila erecta GG18278 (Dere\GG18278), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q09103 1946 5.3e-216 Eye-specific diacylglycerol kinase OS=Drosophila melanogaster GN=rdgA PE=2 SV=2 PF00023//PF13606//PF16866//PF00628//PF00609//PF00130//PF00781 Ankyrin repeat//Ankyrin repeat//PHD-finger//PHD-finger//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase catalytic domain GO:0007205//GO:0009395//GO:0046486//GO:0035556 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process//intracellular signal transduction GO:0016301//GO:0004143//GO:0005515 kinase activity//diacylglycerol kinase activity//protein binding -- -- KOG0782 Predicted diacylglycerol kinase Cluster-8309.21480 BP_3 141.11 0.94 7517 642927149 XP_008195158.1 330 2.7e-27 PREDICTED: uncharacterized protein LOC661334 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09162 Tap, RNA-binding GO:0006406 mRNA export from nucleus GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.21483 BP_3 53.63 0.32 8414 642914930 XP_008190446.1 6655 0.0e+00 PREDICTED: protein slit isoform X3 [Tribolium castaneum] 462424845 APGK01016975.1 99 3.55001e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 5055 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF13855//PF00560//PF00008//PF07645 Leucine rich repeat//Leucine Rich Repeat//EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.21484 BP_3 662.08 8.67 3971 642939478 XP_008197026.1 2215 3.7e-246 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 830 6.1e-87 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF04923//PF07690 Ninjurin//Major Facilitator Superfamily GO:0007155//GO:0055085//GO:0042246 cell adhesion//transmembrane transport//tissue regeneration -- -- GO:0016021 integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.21488 BP_3 48.62 1.72 1653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.21491 BP_3 464.00 19.60 1433 91095011 XP_969955.1 747 2.2e-76 PREDICTED: transcription initiation factor TFIID subunit 9 [Tribolium castaneum]>gi|270015430|gb|EFA11878.1| hypothetical protein TcasGA2_TC004292 [Tribolium castaneum] -- -- -- -- -- K14535 TAF9 transcription initiation factor TFIID subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14535 Q16594 413 4.9e-39 Transcription initiation factor TFIID subunit 9 OS=Homo sapiens GN=TAF9 PE=1 SV=1 PF03510//PF02291 2C endopeptidase (C24) cysteine protease family//Transcription initiation factor IID, 31kD subunit GO:0006352//GO:0006508 DNA-templated transcription, initiation//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG3334 Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) Cluster-8309.21494 BP_3 9.00 0.83 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12398 Receptor serine/threonine kinase GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674 protein serine/threonine kinase activity -- -- -- -- Cluster-8309.21495 BP_3 9215.28 96.57 4891 478259242 ENN79144.1 1222 6.4e-131 hypothetical protein YQE_04330, partial [Dendroctonus ponderosae]>gi|546678424|gb|ERL89047.1| hypothetical protein D910_06425 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGY6 914 1.4e-96 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- -- -- Cluster-8309.21496 BP_3 5.00 1.09 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00950 ABC 3 transport family GO:0006810 transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016020 membrane -- -- Cluster-8309.21497 BP_3 33.49 0.67 2717 268370072 NP_001161228.1 1375 6.4e-149 phosphatidylinositol glycan, class B [Tribolium castaneum] -- -- -- -- -- K05286 PIGB phosphatidylinositol glycan, class B http://www.genome.jp/dbget-bin/www_bget?ko:K05286 Q9VZM5 1081 3.3e-116 GPI mannosyltransferase 3 OS=Drosophila melanogaster GN=CG12006 PE=2 SV=2 PF10588//PF03901 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Alg9-like mannosyltransferase family GO:0055114 oxidation-reduction process GO:0016757//GO:0016491 transferase activity, transferring glycosyl groups//oxidoreductase activity -- -- KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis Cluster-8309.21498 BP_3 1279.51 26.67 2604 268370072 NP_001161228.1 1717 1.4e-188 phosphatidylinositol glycan, class B [Tribolium castaneum] -- -- -- -- -- K05286 PIGB phosphatidylinositol glycan, class B http://www.genome.jp/dbget-bin/www_bget?ko:K05286 Q9VZM5 1277 5.8e-139 GPI mannosyltransferase 3 OS=Drosophila melanogaster GN=CG12006 PE=2 SV=2 PF10588//PF03901 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Alg9-like mannosyltransferase family GO:0055114 oxidation-reduction process GO:0016757//GO:0016491 transferase activity, transferring glycosyl groups//oxidoreductase activity -- -- KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis Cluster-8309.21499 BP_3 75.00 12.20 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21500 BP_3 30.00 12.21 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08119 Scorpion acidic alpha-KTx toxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21502 BP_3 31.87 0.43 3856 642939483 XP_966848.2 763 8.4e-78 PREDICTED: transcription elongation factor B polypeptide 3 [Tribolium castaneum]>gi|642939485|ref|XP_008193753.1| PREDICTED: transcription elongation factor B polypeptide 3 [Tribolium castaneum]>gi|270016551|gb|EFA12997.1| hypothetical protein TcasGA2_TC001477 [Tribolium castaneum] -- -- -- -- -- K15076 TCEB3, ELOA transcription elongation factor B, polypeptide 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15076 Q9VCP0 531 2.8e-52 Transcription elongation factor B polypeptide 3 OS=Drosophila melanogaster GN=EloA PE=1 SV=1 PF01790//PF06881//PF08711 Prolipoprotein diacylglyceryl transferase//RNA polymerase II transcription factor SIII (Elongin) subunit A//TFIIS helical bundle-like domain GO:0042158//GO:0006351//GO:0009249//GO:0006355 lipoprotein biosynthetic process//transcription, DNA-templated//protein lipoylation//regulation of transcription, DNA-templated GO:0003677//GO:0016757 DNA binding//transferase activity, transferring glycosyl groups GO:0016021//GO:0005634//GO:0016020 integral component of membrane//nucleus//membrane KOG2821 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin A Cluster-8309.21505 BP_3 10.00 1.52 608 194754227 XP_001959397.1 324 1.1e-27 GF12852 [Drosophila ananassae]>gi|190620695|gb|EDV36219.1| GF12852 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- Q7M4F3 269 1.0e-22 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF09462//PF00379 Mus7/MMS22 family//Insect cuticle protein GO:0006974//GO:0006281//GO:0031297 cellular response to DNA damage stimulus//DNA repair//replication fork processing GO:0042302 structural constituent of cuticle GO:0005634 nucleus -- -- Cluster-8309.21507 BP_3 30.88 1.56 1246 748995296 AJE75670.1 1533 1.4e-167 putative glycosyl hydrolase [Chrysomela lapponica] 585688740 XM_006820670.1 36 5.39592e-07 PREDICTED: Saccoglossus kowalevskii lactase-phlorizin hydrolase-like (LOC102800751), mRNA K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q6UWM7 871 3.3e-92 Lactase-like protein OS=Homo sapiens GN=LCTL PE=1 SV=2 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.21509 BP_3 67.96 2.50 1602 642921686 XP_008194679.1 417 4.6e-38 PREDICTED: uncharacterized protein LOC658244 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21511 BP_3 28.00 2.31 876 270013391 EFA09839.1 1453 1.9e-158 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 105 1.64999e-45 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P10079 206 3.0e-15 Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.21513 BP_3 22.00 0.75 1707 728418332 AIY68365.1 1553 9.2e-170 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 632 2.4e-64 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF01991//PF07859 ATP synthase (E/31 kDa) subunit//alpha/beta hydrolase fold GO:0006119//GO:0015992//GO:0015991//GO:0008152 oxidative phosphorylation//proton transport//ATP hydrolysis coupled proton transport//metabolic process GO:0046961//GO:0016787 proton-transporting ATPase activity, rotational mechanism//hydrolase activity GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.21515 BP_3 294.00 3.81 4014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21516 BP_3 12.69 0.36 1978 91087699 XP_974256.1 900 5.6e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 3.8e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.2152 BP_3 4.00 0.32 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05366 Sarcolipin -- -- GO:0030234 enzyme regulator activity GO:0016020 membrane -- -- Cluster-8309.21520 BP_3 279.48 5.27 2847 642919713 XP_008192033.1 1789 6.6e-197 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.6e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.21527 BP_3 7.04 0.33 1307 818214314 AKG26772.1 1037 4.8e-110 peroxiredoxin 1 [Dastarcus helophoroides] 665815945 XM_008558436.1 80 1.96763e-31 PREDICTED: Microplitis demolitor peroxiredoxin-2 (LOC103577681), partial mRNA K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9BGI2 894 7.5e-95 Peroxiredoxin-4 OS=Bos taurus GN=PRDX4 PE=2 SV=1 PF00578//PF08534//PF10417 AhpC/TSA family//Redoxin//C-terminal domain of 1-Cys peroxiredoxin GO:0055114 oxidation-reduction process GO:0051920//GO:0016209//GO:0016491 peroxiredoxin activity//antioxidant activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.21528 BP_3 642.00 15.56 2281 646718890 KDR21193.1 239 2.9e-17 putative helicase senataxin [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00498 FHA domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21530 BP_3 316.00 12.96 1467 665806811 XP_008551661.1 539 3.0e-52 PREDICTED: uncharacterized protein LOC103574088 [Microplitis demolitor] -- -- -- -- -- K10706 SETX, ALS4 senataxin http://www.genome.jp/dbget-bin/www_bget?ko:K10706 O94387 475 3.3e-46 Uncharacterized ATP-dependent helicase C29A10.10c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC29A10.10c PE=3 SV=1 PF01443 Viral (Superfamily 1) RNA helicase -- -- GO:0005524 ATP binding -- -- KOG1801 tRNA-splicing endonuclease positive effector (SEN1) Cluster-8309.21536 BP_3 47.22 0.34 7076 642937185 XP_008198729.1 2693 2.5e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 3.80453e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.4e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF11744//PF05192//PF05033//PF00995//PF00023//PF02068//PF13606 Aluminium activated malate transporter//MutS domain III//Pre-SET motif//Sec1 family//Ankyrin repeat//Plant PEC family metallothionein//Ankyrin repeat GO:0006479//GO:0006554//GO:0006298//GO:0016192//GO:0034968//GO:0006904//GO:0015743 protein methylation//lysine catabolic process//mismatch repair//vesicle-mediated transport//histone lysine methylation//vesicle docking involved in exocytosis//malate transport GO:0030983//GO:0008270//GO:0018024//GO:0005524//GO:0005515 mismatched DNA binding//zinc ion binding//histone-lysine N-methyltransferase activity//ATP binding//protein binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.21542 BP_3 376.00 4.28 4528 645026360 XP_008212069.1 911 6.8e-95 PREDICTED: uncharacterized protein LOC100680303 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q9Y4A0 155 1.3e-08 Jerky protein homolog-like OS=Homo sapiens GN=JRKL PE=2 SV=2 PF03184//PF15333//PF02796//PF05225//PF07975 DDE superfamily endonuclease//TATA box-binding protein-associated factor 1D//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//TFIIH C1-like domain GO:0006281//GO:0006310//GO:0006355 DNA repair//DNA recombination//regulation of transcription, DNA-templated GO:0000150//GO:0003677//GO:0003676//GO:0008270 recombinase activity//DNA binding//nucleic acid binding//zinc ion binding GO:0005634//GO:0005668 nucleus//RNA polymerase transcription factor SL1 complex -- -- Cluster-8309.21543 BP_3 2.00 0.73 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21546 BP_3 131.90 2.77 2587 546678697 ERL89265.1 1371 1.8e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 3.2e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.21548 BP_3 8.17 0.74 824 270011898 EFA08346.1 426 2.1e-39 hypothetical protein TcasGA2_TC005989 [Tribolium castaneum] -- -- -- -- -- K14005 SEC31 protein transport protein SEC31 http://www.genome.jp/dbget-bin/www_bget?ko:K14005 Q3UPL0 227 1.0e-17 Protein transport protein Sec31A OS=Mus musculus GN=Sec31a PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0307 Vesicle coat complex COPII, subunit SEC31 Cluster-8309.2155 BP_3 82.53 2.72 1752 478263841 ENN82073.1 328 1.1e-27 hypothetical protein YQE_01549, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21550 BP_3 191.07 1.70 5697 91086191 XP_971352.1 1528 2.4e-166 PREDICTED: WD repeat-containing protein 92 [Tribolium castaneum]>gi|270010235|gb|EFA06683.1| hypothetical protein TcasGA2_TC009613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29RZ9 1178 3.9e-127 WD repeat-containing protein 92 OS=Bos taurus GN=WDR92 PE=2 SV=1 PF02391//PF00400//PF10741 MoaE protein//WD domain, G-beta repeat//Type II secretion system (T2SS), protein M subtype b GO:0006858//GO:0006777 extracellular transport//Mo-molybdopterin cofactor biosynthetic process GO:0005515 protein binding -- -- KOG3307 Molybdopterin converting factor subunit 2 Cluster-8309.21552 BP_3 54.54 1.80 1750 270009873 EFA06321.1 443 4.9e-41 hypothetical protein TcasGA2_TC009192 [Tribolium castaneum] -- -- -- -- -- K03635 MOCS2, moaE molybdopterin synthase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03635 B5FXU9 388 4.8e-36 Molybdopterin synthase catalytic subunit OS=Taeniopygia guttata GN=MOCS2 PE=2 SV=1 PF02391 MoaE protein GO:0006777 Mo-molybdopterin cofactor biosynthetic process -- -- -- -- KOG3307 Molybdopterin converting factor subunit 2 Cluster-8309.21553 BP_3 51.05 1.71 1728 642929605 XP_008195901.1 899 6.4e-94 PREDICTED: polyadenylate-binding protein 2 isoform X1 [Tribolium castaneum]>gi|270010566|gb|EFA07014.1| hypothetical protein TcasGA2_TC009984 [Tribolium castaneum] 196012775 XM_002116214.1 70 9.48598e-26 Trichoplax adhaerens hypothetical protein, mRNA K14396 PABPN1, PABP2 polyadenylate-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14396 Q28ZX3 645 7.4e-66 Polyadenylate-binding protein 2 OS=Drosophila pseudoobscura pseudoobscura GN=Pabp2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.21554 BP_3 6.18 0.50 893 478251541 ENN72003.1 330 3.1e-28 hypothetical protein YQE_11294, partial [Dendroctonus ponderosae]>gi|546681207|gb|ERL91342.1| hypothetical protein D910_08674 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q98943 143 6.2e-08 Caspase-2 OS=Gallus gallus GN=CASP2 PE=2 SV=2 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.21555 BP_3 817.16 30.76 1572 546677956 ERL88689.1 466 9.4e-44 hypothetical protein D910_06072 [Dendroctonus ponderosae] -- -- -- -- -- K00310 SE pyrimidodiazepine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00310 Q9VSL3 157 2.6e-09 Pyrimidodiazepine synthase OS=Drosophila melanogaster GN=se PE=1 SV=1 PF01140//PF05485 Matrix protein (MA), p15//THAP domain -- -- GO:0005198//GO:0003676 structural molecule activity//nucleic acid binding GO:0019028 viral capsid -- -- Cluster-8309.21558 BP_3 1038.58 73.16 976 748762529 AJE61312.1 726 4.1e-74 glutathione S-transeferase [Dendroctonus armandi] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VSL3 390 1.6e-36 Pyrimidodiazepine synthase OS=Drosophila melanogaster GN=se PE=1 SV=1 PF02798//PF00462//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG0406 Glutathione S-transferase Cluster-8309.21559 BP_3 12.33 0.73 1104 546672885 ERL84608.1 618 1.6e-61 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 410 8.5e-39 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF00108 Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.2156 BP_3 54.00 2.51 1327 478259952 ENN79754.1 1038 3.7e-110 hypothetical protein YQE_03810, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07168 Ureide permease GO:0071705 nitrogen compound transport -- -- -- -- -- -- Cluster-8309.21560 BP_3 10.00 0.33 1733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21567 BP_3 19.81 0.44 2484 91079546 XP_971272.1 172 1.8e-09 PREDICTED: uncharacterized protein LOC659913 [Tribolium castaneum]>gi|270003419|gb|EEZ99866.1| hypothetical protein TcasGA2_TC002648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03505 Clostridium enterotoxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.21568 BP_3 24.71 0.60 2263 642934936 XP_008195867.1 774 2.6e-79 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 205 1.12268e-100 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 228 2.2e-17 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21569 BP_3 116.80 0.53 10823 642934938 XP_008195872.1 2976 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X2 [Tribolium castaneum] 462277734 APGK01058896.1 184 2.56308e-88 Dendroctonus ponderosae Seq01058906, whole genome shotgun sequence -- -- -- -- Q95YM8 548 8.3e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05197//PF05225 TRIC channel//helix-turn-helix, Psq domain GO:0006812//GO:0015672 cation transport//monovalent inorganic cation transport GO:0005261//GO:0003677 cation channel activity//DNA binding GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.2157 BP_3 13.09 0.39 1901 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21570 BP_3 16.59 0.67 1479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21571 BP_3 49.00 1.46 1914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21576 BP_3 56.31 0.43 6646 91091174 XP_971600.1 957 4.6e-100 PREDICTED: calmodulin-lysine N-methyltransferase isoform X1 [Tribolium castaneum]>gi|270013122|gb|EFA09570.1| hypothetical protein TcasGA2_TC011684 [Tribolium castaneum] 662202247 XM_008476190.1 52 3.75347e-15 PREDICTED: Diaphorina citri WW domain-binding protein 4-like (LOC103511468), mRNA K18826 CAMKMT calmodulin-lysine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18826 Q3U2J5 425 9.3e-40 Calmodulin-lysine N-methyltransferase OS=Mus musculus GN=Camkmt PE=1 SV=1 PF05401//PF08241//PF05175//PF00397 Nodulation protein S (NodS)//Methyltransferase domain//Methyltransferase small domain//WW domain GO:0008152//GO:0009877//GO:0009312 metabolic process//nodulation//oligosaccharide biosynthetic process GO:0008168//GO:0008757//GO:0005515 methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//protein binding -- -- KOG3201 Uncharacterized conserved protein Cluster-8309.21577 BP_3 5.77 0.32 1173 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01599 Ribosomal protein S27a GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.21579 BP_3 507.95 16.58 1768 642911140 XP_008200597.1 608 3.6e-60 PREDICTED: protein phosphatase 1 regulatory subunit SDS22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IIW9 144 9.5e-08 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Xenopus tropicalis GN=lingo1 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21580 BP_3 839.65 13.86 3211 91085809 XP_974684.1 1660 6.8e-182 PREDICTED: protein Wnt-5b [Tribolium castaneum]>gi|270011028|gb|EFA07476.1| hypothetical protein TcasGA2_TC009318 [Tribolium castaneum] -- -- -- -- -- K00444 WNT5 wingless-type MMTV integration site family, member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K00444 Q5NVK2 1071 5.5e-115 Protein Wnt-5b OS=Pongo abelii GN=WNT5B PE=2 SV=1 PF00110//PF07850 wnt family//Renin receptor-like protein GO:0007275//GO:0016055//GO:0007165 multicellular organismal development//Wnt signaling pathway//signal transduction GO:0005102//GO:0004872 receptor binding//receptor activity GO:0005578//GO:0005576//GO:0016021 proteinaceous extracellular matrix//extracellular region//integral component of membrane -- -- Cluster-8309.21581 BP_3 2.00 0.32 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04565 RNA polymerase Rpb2, domain 3 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.21584 BP_3 140.00 6.91 1268 91094831 XP_971314.1 1015 1.7e-107 PREDICTED: pre-mRNA-splicing factor SPF27 [Tribolium castaneum]>gi|270006573|gb|EFA03021.1| hypothetical protein TcasGA2_TC010444 [Tribolium castaneum] 571574579 XM_006563437.1 143 1.81515e-66 PREDICTED: Apis mellifera pre-mRNA-splicing factor SPF27 (Bcas2), transcript variant X2, mRNA K12861 BCAS2 pre-mRNA-splicing factor SPF27 http://www.genome.jp/dbget-bin/www_bget?ko:K12861 O75934 631 2.3e-64 Pre-mRNA-splicing factor SPF27 OS=Homo sapiens GN=BCAS2 PE=1 SV=1 PF05700//PF14073 Breast carcinoma amplified sequence 2 (BCAS2)//Centrosome localisation domain of Cep57 GO:0006397 mRNA processing GO:0043015//GO:0042802 gamma-tubulin binding//identical protein binding GO:0045298 tubulin complex KOG3096 Spliceosome-associated coiled-coil protein Cluster-8309.21590 BP_3 103.91 2.63 2194 270011990 EFA08438.1 525 1.9e-50 hypothetical protein TcasGA2_TC006085 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11365 Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy -- -- GO:0005615 extracellular space -- -- Cluster-8309.21595 BP_3 12.72 0.45 1649 546672637 ERL84433.1 1024 2.0e-108 hypothetical protein D910_01865, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5YCC5 398 3.1e-37 Transmembrane channel-like protein 7 OS=Gallus gallus GN=Tmc7 PE=2 SV=1 PF06305//PF07810 Protein of unknown function (DUF1049)//TMC domain -- -- -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.21598 BP_3 55.36 2.34 1434 642931613 XP_008196656.1 1493 7.0e-163 PREDICTED: sphingomyelin phosphodiesterase isoform X2 [Tribolium castaneum] 808137240 XR_001099267.1 41 1.03575e-09 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 409 1.4e-38 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.21599 BP_3 15.80 0.42 2126 642931613 XP_008196656.1 2783 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase isoform X2 [Tribolium castaneum] 808137240 XR_001099267.1 138 1.85263e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1172 7.1e-127 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.216 BP_3 23.00 0.64 2018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21603 BP_3 7190.85 130.83 2941 91083957 XP_975021.1 1142 7.2e-122 PREDICTED: caldesmon [Tribolium castaneum]>gi|270006722|gb|EFA03170.1| hypothetical protein TcasGA2_TC013090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09002 147 7.1e-08 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF02075//PF00836//PF01418 Crossover junction endodeoxyribonuclease RuvC//Stathmin family//Helix-turn-helix domain, rpiR family GO:0006281//GO:0006308//GO:0031110//GO:0006355//GO:0006310 DNA repair//DNA catabolic process//regulation of microtubule polymerization or depolymerization//regulation of transcription, DNA-templated//DNA recombination GO:0004520//GO:0003700 endodeoxyribonuclease activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.21610 BP_3 12.22 0.40 1756 91089209 XP_967093.1 1043 1.3e-110 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog [Tribolium castaneum]>gi|270012470|gb|EFA08918.1| hypothetical protein TcasGA2_TC006624 [Tribolium castaneum] -- -- -- -- -- K14439 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14439 Q9VL72 483 4.6e-47 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog OS=Drosophila melanogaster GN=Etl1 PE=1 SV=1 PF00176//PF02845//PF04851//PF05837 SNF2 family N-terminal domain//CUE domain//Type III restriction enzyme, res subunit//Centromere protein H (CENP-H) GO:0051382 kinetochore assembly GO:0005515//GO:0016787//GO:0003677//GO:0005524 protein binding//hydrolase activity//DNA binding//ATP binding GO:0000776 kinetochore KOG0389 SNF2 family DNA-dependent ATPase Cluster-8309.21614 BP_3 358.38 6.34 3016 642938354 XP_008198798.1 565 6.0e-55 PREDICTED: peptidyl-prolyl cis-trans isomerase G [Tribolium castaneum] 645259408 XM_008237125.1 62 4.67392e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 A2AR02 457 8.2e-44 Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus GN=Ppig PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.21618 BP_3 1.00 0.37 422 607353932 EZA48617.1 145 4.2e-07 hypothetical protein X777_13627, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21619 BP_3 357.00 8.41 2338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.2162 BP_3 5.00 1.66 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21620 BP_3 23.00 1.49 1037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21623 BP_3 21.00 0.56 2093 91077618 XP_973779.1 1931 1.7e-213 PREDICTED: protein Malvolio [Tribolium castaneum]>gi|270001554|gb|EEZ98001.1| hypothetical protein TcasGA2_TC000399 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1731 1.1e-191 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF01566 Natural resistance-associated macrophage protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.21624 BP_3 578.42 63.18 733 91083431 XP_969550.1 401 1.5e-36 PREDICTED: membrane magnesium transporter 1 [Tribolium castaneum]>gi|270007793|gb|EFA04241.1| hypothetical protein TcasGA2_TC014495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28HV5 263 6.2e-22 Membrane magnesium transporter 1 OS=Xenopus tropicalis GN=mmgt1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3918 Predicted membrane protein Cluster-8309.21630 BP_3 71.20 1.10 3414 642913638 XP_008201098.1 2740 4.2e-307 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 3.0e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF01055//PF03539 Glycosyl hydrolases family 31//Spumavirus aspartic protease (A9) GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004190//GO:0004553 aspartic-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21632 BP_3 30.29 0.33 4775 642913646 XP_008201102.1 2668 1.3e-298 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 4.2e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF01055//PF03539 Glycosyl hydrolases family 31//Spumavirus aspartic protease (A9) GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004190//GO:0004553 aspartic-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21633 BP_3 38.41 0.39 5069 642913640 XP_008201099.1 2668 1.4e-298 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum]>gi|642913648|ref|XP_008201103.1| PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 4.4e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF03539//PF01055 Spumavirus aspartic protease (A9)//Glycosyl hydrolases family 31 GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004190 hydrolase activity, hydrolyzing O-glycosyl compounds//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.21634 BP_3 375.13 4.30 4494 642926793 XP_008195018.1 3653 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 61 2.51479e-20 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2149 7.7e-240 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF01068//PF00023//PF00651//PF13606 ATP dependent DNA ligase domain//Ankyrin repeat//BTB/POZ domain//Ankyrin repeat GO:0006281//GO:0006310//GO:0006260 DNA repair//DNA recombination//DNA replication GO:0003910//GO:0005515//GO:0005524 DNA ligase (ATP) activity//protein binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.21635 BP_3 58.00 2.02 1677 642915730 XP_008190779.1 1118 2.5e-119 PREDICTED: uncharacterized protein LOC103312285 [Tribolium castaneum]>gi|270003790|gb|EFA00238.1| hypothetical protein TcasGA2_TC003066 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 Q9NWF9 442 2.5e-42 E3 ubiquitin-protein ligase RNF216 OS=Homo sapiens GN=RNF216 PE=1 SV=3 PF02807//PF10044 ATP:guanido phosphotransferase, N-terminal domain//Retinal tissue protein GO:0007049//GO:0006351 cell cycle//transcription, DNA-templated GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups GO:0070176 DRM complex -- -- Cluster-8309.21644 BP_3 453.00 10.71 2330 531446594 AGT57844.1 1395 2.6e-151 cytochrome P450 315a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10722 SAD, CYP315A1 ecdysteroid 2-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10722 Q9VGH1 855 4.5e-90 Cytochrome P450 315a1, mitochondrial OS=Drosophila melanogaster GN=sad PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.21645 BP_3 28.00 1.53 1172 16903179 AAK61417.1 455 1.3e-42 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21646 BP_3 38.27 1.29 1721 307197059 EFN78431.1 161 2.4e-08 Transposable element Tc3 transposase, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21649 BP_3 3.00 0.68 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21654 BP_3 151.28 1.77 4419 642923817 XP_001816010.2 2335 5.0e-260 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 1.68281e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q5RED8 1071 7.6e-115 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Pongo abelii GN=CYLD PE=2 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG3556 Familial cylindromatosis protein Cluster-8309.21656 BP_3 107.58 1.60 3530 642911317 XP_008199368.1 226 1.4e-15 PREDICTED: uncharacterized protein LOC103314647 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064//PF09508 Sleepless protein//Lacto-N-biose phosphorylase GO:0030431//GO:1903818//GO:0032222 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic GO:0034235//GO:0016758 GPI anchor binding//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.21657 BP_3 433.99 20.85 1295 478255254 ENN75483.1 965 1.1e-101 hypothetical protein YQE_08032, partial [Dendroctonus ponderosae]>gi|546681559|gb|ERL91630.1| hypothetical protein D910_08960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9JJ06 231 5.7e-18 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Mus musculus GN=C1galt1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2246 Galactosyltransferases Cluster-8309.21662 BP_3 16.03 0.76 1311 751657284 AJF94901.1 1074 2.5e-114 C1 family cathepsin B33 [Tenebrio molitor] 543271545 XM_005424950.1 99 5.41084e-42 PREDICTED: Geospiza fortis cathepsin B (CTSB), mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 965 4.4e-103 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF03320//PF08127//PF00112//PF03051 Bacterial fructose-1,6-bisphosphatase, glpX-encoded//Peptidase family C1 propeptide//Papain family cysteine protease//Peptidase C1-like family GO:0006508//GO:0015976//GO:0006094//GO:0006000//GO:0050790//GO:0006071//GO:0006013//GO:0006098//GO:0006096 proteolysis//carbon utilization//gluconeogenesis//fructose metabolic process//regulation of catalytic activity//glycerol metabolic process//mannose metabolic process//pentose-phosphate shunt//glycolytic process GO:0008234//GO:0004197//GO:0042132 cysteine-type peptidase activity//cysteine-type endopeptidase activity//fructose 1,6-bisphosphate 1-phosphatase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.21668 BP_3 22.95 0.34 3542 642921234 XP_008192774.1 1587 2.2e-173 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X3 [Tribolium castaneum] 642921233 XM_008194552.1 277 1.66892e-140 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X6, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 651 3.1e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF13606//PF14604//PF00023//PF00018 Ankyrin repeat//Variant SH3 domain//Ankyrin repeat//SH3 domain -- -- GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.21673 BP_3 636.67 27.47 1409 91087465 XP_967435.1 908 4.7e-95 PREDICTED: uncharacterized protein LOC655780 [Tribolium castaneum]>gi|270010660|gb|EFA07108.1| hypothetical protein TcasGA2_TC010098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21674 BP_3 52.34 0.54 5001 642930933 XP_008196147.1 663 4.3e-66 PREDICTED: RILP-like protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76878 477 6.5e-46 RILP-like protein homolog OS=Drosophila melanogaster GN=CG11448 PE=2 SV=1 PF04617//PF07851//PF10186//PF02465//PF15048//PF01401//PF00769//PF17060 Hox9 activation region//TMPIT-like protein//Vacuolar sorting 38 and autophagy-related subunit 14//Flagellar hook-associated protein 2 N-terminus//Organic solute transporter subunit beta protein//Angiotensin-converting enzyme//Ezrin/radixin/moesin family//Monopolar spindle protein 2 GO:0006508//GO:0071988//GO:0030474//GO:0006351//GO:0010508//GO:0015721//GO:0006810 proteolysis//protein localization to spindle pole body//spindle pole body duplication//transcription, DNA-templated//positive regulation of autophagy//bile acid and bile salt transport//transport GO:0008237//GO:0005215//GO:0046982//GO:0008092//GO:0008241 metallopeptidase activity//transporter activity//protein heterodimerization activity//cytoskeletal protein binding//peptidyl-dipeptidase activity GO:0016020//GO:0009424//GO:0005634//GO:0005886//GO:0005737//GO:0016021//GO:0019898 membrane//bacterial-type flagellum hook//nucleus//plasma membrane//cytoplasm//integral component of membrane//extrinsic component of membrane KOG2998 Uncharacterized conserved protein Cluster-8309.21677 BP_3 8.38 0.39 1337 270006792 EFA03240.1 157 5.4e-08 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21678 BP_3 3.00 0.52 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21680 BP_3 539.59 7.58 3723 91081979 XP_968359.1 3692 0.0e+00 PREDICTED: ubiquitin-protein ligase E3C [Tribolium castaneum]>gi|270007369|gb|EFA03817.1| hypothetical protein TcasGA2_TC013932 [Tribolium castaneum] -- -- -- -- -- K10589 UBE3C ubiquitin-protein ligase E3 C http://www.genome.jp/dbget-bin/www_bget?ko:K10589 Q15386 1282 2.2e-139 Ubiquitin-protein ligase E3C OS=Homo sapiens GN=UBE3C PE=1 SV=3 PF00632//PF00612 HECT-domain (ubiquitin-transferase)//IQ calmodulin-binding motif GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.21681 BP_3 190.90 2.66 3753 91081979 XP_968359.1 3586 0.0e+00 PREDICTED: ubiquitin-protein ligase E3C [Tribolium castaneum]>gi|270007369|gb|EFA03817.1| hypothetical protein TcasGA2_TC013932 [Tribolium castaneum] -- -- -- -- -- K10589 UBE3C ubiquitin-protein ligase E3 C http://www.genome.jp/dbget-bin/www_bget?ko:K10589 Q15386 1282 2.2e-139 Ubiquitin-protein ligase E3C OS=Homo sapiens GN=UBE3C PE=1 SV=3 PF00612//PF00632 IQ calmodulin-binding motif//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.21682 BP_3 31.00 1.17 1565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21685 BP_3 72.52 0.83 4528 91080113 XP_967415.1 1588 2.1e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit I [Tribolium castaneum]>gi|270003188|gb|EEZ99635.1| hypothetical protein TcasGA2_TC002391 [Tribolium castaneum] 642918634 XM_962322.2 236 1.32385e-117 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 3 subunit I (LOC655760), mRNA K03246 EIF3I translation initiation factor 3 subunit I http://www.genome.jp/dbget-bin/www_bget?ko:K03246 Q1HPW4 1315 4.0e-143 Eukaryotic translation initiation factor 3 subunit I OS=Bombyx mori PE=2 SV=1 PF10766//PF00400//PF10505//PF04053 Multidrug efflux pump-associated protein AcrZ//WD domain, G-beta repeat//NMDA receptor-regulated gene protein 2 C-terminus//Coatomer WD associated region GO:0015893//GO:0006855//GO:0016192//GO:0006886 drug transport//drug transmembrane transport//vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515//GO:0015238 structural molecule activity//protein binding//drug transmembrane transporter activity GO:0030117//GO:0008023//GO:0005886 membrane coat//transcription elongation factor complex//plasma membrane KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) Cluster-8309.21686 BP_3 201.71 21.45 745 91087295 XP_975560.1 596 3.8e-59 PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum]>gi|642929763|ref|XP_008195964.1| PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V968 522 5.9e-52 MIP18 family protein CG30152 OS=Drosophila melanogaster GN=CG30152 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3381 Uncharacterized conserved protein Cluster-8309.21694 BP_3 1.00 1.20 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451//PF08086 Scorpion short toxin, BmKK2//Ergtoxin family GO:0006810//GO:0009405 transport//pathogenesis GO:0019870//GO:0008200 potassium channel inhibitor activity//ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21696 BP_3 25.09 0.77 1871 91087581 XP_971751.1 827 1.5e-85 PREDICTED: peroxisomal membrane protein PMP34 [Tribolium castaneum]>gi|270009432|gb|EFA05880.1| hypothetical protein TcasGA2_TC008692 [Tribolium castaneum] -- -- -- -- -- K13354 SLC25A17, PMP34 solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17 http://www.genome.jp/dbget-bin/www_bget?ko:K13354 O70579 557 1.3e-55 Peroxisomal membrane protein PMP34 OS=Mus musculus GN=Slc25a17 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0769 Predicted mitochondrial carrier protein Cluster-8309.21699 BP_3 41.87 0.59 3710 642910285 XP_008198690.1 1025 3.4e-108 PREDICTED: LOW QUALITY PROTEIN: solute carrier organic anion transporter family member 4C1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99N02 248 1.7e-19 Solute carrier organic anion transporter family member 3A1 OS=Rattus norvegicus GN=Slco3a1 PE=2 SV=1 PF03137//PF07690 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.217 BP_3 4.00 0.71 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21702 BP_3 276.74 30.57 728 642928994 XP_008195648.1 438 7.7e-41 PREDICTED: eukaryotic translation elongation factor 1 epsilon-1 [Tribolium castaneum] -- -- -- -- -- K15439 EEF1E1, AIMP3 eukaryotic translation elongation factor 1 epsilon-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15439 O43324 218 1.0e-16 Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens GN=EEF1E1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21703 BP_3 283.37 7.84 2033 478254824 ENN75060.1 1612 1.6e-176 hypothetical protein YQE_08373, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DKP5 993 3.9e-106 WD repeat-containing protein 13 OS=Pan troglodytes GN=WDR13 PE=3 SV=1 PF00400//PF02975 WD domain, G-beta repeat//Methylamine dehydrogenase, L chain GO:0055114//GO:0009308 oxidation-reduction process//amine metabolic process GO:0005515//GO:0016638 protein binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0042597 periplasmic space KOG0266 WD40 repeat-containing protein Cluster-8309.2171 BP_3 34.00 0.40 4437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21715 BP_3 155.07 7.47 1292 546684136 ERL93841.1 247 1.9e-18 hypothetical protein D910_11127, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02102 Deuterolysin metalloprotease (M35) family GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.21718 BP_3 116.76 2.53 2519 642914452 XP_008201682.1 2297 7.3e-256 PREDICTED: GRAM domain-containing protein 1B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RC33 721 1.7e-74 GRAM domain-containing protein 1C OS=Pongo abelii GN=GRAMD1C PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.21720 BP_3 9.00 0.58 1039 700894659 AIU99748.1 367 1.9e-32 mitochondrial cytochrome c oxidase subunit VIa precursor [Litopenaeus vannamei] -- -- -- -- -- K02266 COX6A cytochrome c oxidase subunit 6a http://www.genome.jp/dbget-bin/www_bget?ko:K02266 O13085 251 2.2e-20 Cytochrome c oxidase subunit 6A, mitochondrial OS=Oncorhynchus mykiss PE=3 SV=1 PF02046//PF04093 Cytochrome c oxidase subunit VIa//rod shape-determining protein MreD GO:0006123//GO:0015992//GO:0008360 mitochondrial electron transport, cytochrome c to oxygen//proton transport//regulation of cell shape GO:0004129 cytochrome-c oxidase activity GO:0016021//GO:0005743//GO:0045277//GO:0005751 integral component of membrane//mitochondrial inner membrane//respiratory chain complex IV//mitochondrial respiratory chain complex IV KOG3469 Cytochrome c oxidase, subunit VIa/COX13 Cluster-8309.21722 BP_3 147.78 1.91 4028 189234728 XP_001814259.1 801 3.4e-82 PREDICTED: ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 [Tribolium castaneum]>gi|270001556|gb|EEZ98003.1| hypothetical protein TcasGA2_TC000402 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4D7T3 263 3.4e-21 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 OS=Macropus eugenii GN=ASZ1 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21723 BP_3 100.00 9.62 793 675366016 KFM58918.1 579 3.7e-57 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q7JQ07 294 1.7e-25 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF00665//PF08094 Integrase core domain//Conotoxin TVIIA/GS family GO:0009405//GO:0006810//GO:0015074 pathogenesis//transport//DNA integration GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21725 BP_3 27.37 0.37 3833 270004296 EFA00744.1 644 5.3e-64 hypothetical protein TcasGA2_TC003626 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03800//PF05225 Nuf2 family//helix-turn-helix, Psq domain GO:0007067 mitotic nuclear division GO:0003677 DNA binding GO:0000775 chromosome, centromeric region -- -- Cluster-8309.21726 BP_3 22.63 1.54 999 642916711 XP_008192290.1 669 1.7e-67 PREDICTED: protein bric-a-brac 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03800//PF05225 Nuf2 family//helix-turn-helix, Psq domain GO:0007067 mitotic nuclear division GO:0003677 DNA binding GO:0000775 chromosome, centromeric region -- -- Cluster-8309.21727 BP_3 30.06 0.85 1987 642916711 XP_008192290.1 978 5.1e-103 PREDICTED: protein bric-a-brac 1-like [Tribolium castaneum] 642916710 XM_008194068.1 323 2.49448e-166 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100142273), mRNA -- -- -- -- Q9W0K4 543 5.8e-54 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21728 BP_3 5.32 0.34 1056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21733 BP_3 355.20 2.41 7381 642929587 XP_975389.2 4308 0.0e+00 PREDICTED: uncharacterized protein LOC664289 isoform X3 [Tribolium castaneum] 642929586 XM_970296.2 70 4.11231e-25 PREDICTED: Tribolium castaneum uncharacterized LOC664289 (LOC664289), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2174 BP_3 1183.00 70.11 1105 478259314 ENN79216.1 495 2.9e-47 hypothetical protein YQE_04400, partial [Dendroctonus ponderosae]>gi|546675052|gb|ERL86307.1| hypothetical protein D910_03715 [Dendroctonus ponderosae] 759055337 XM_011338596.1 34 6.17506e-06 PREDICTED: Cerapachys biroi uncharacterized LOC105279056 (LOC105279056), mRNA -- -- -- -- -- -- -- -- PF11837 Domain of unknown function (DUF3357) GO:0006012//GO:0005985//GO:0005982 galactose metabolic process//sucrose metabolic process//starch metabolic process GO:0004564//GO:0004575 beta-fructofuranosidase activity//sucrose alpha-glucosidase activity GO:0017177 glucosidase II complex -- -- Cluster-8309.21740 BP_3 3.00 0.58 541 546682441 ERL92374.1 145 5.4e-07 hypothetical protein D910_09688 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21741 BP_3 466.00 13.53 1952 546682441 ERL92374.1 683 8.0e-69 hypothetical protein D910_09688 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7ZYB4 220 1.6e-16 Polyadenylate-binding protein-interacting protein 1 OS=Xenopus laevis GN=paip1 PE=1 SV=1 PF02854 MIF4G domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.21742 BP_3 7.79 0.48 1074 332372730 AEE61507.1 733 7.0e-75 unknown [Dendroctonus ponderosae] 817052986 XM_012404120.1 152 1.52071e-71 PREDICTED: Athalia rosae SUMO-conjugating enzyme UBC9-B (LOC105688078), mRNA K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 Q9DDJ0 655 3.2e-67 SUMO-conjugating enzyme UBC9-B OS=Danio rerio GN=ube2ib PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.21744 BP_3 142.00 9.36 1023 91078208 XP_968880.1 1192 4.0e-128 PREDICTED: exosome complex component RRP4 [Tribolium castaneum]>gi|270002359|gb|EEZ98806.1| hypothetical protein TcasGA2_TC001377 [Tribolium castaneum] -- -- -- -- -- K03679 RRP4, EXOSC2 exosome complex component RRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K03679 Q2KID0 821 1.7e-86 Exosome complex component RRP4 OS=Bos taurus GN=EXOSC2 PE=2 SV=1 PF15985//PF10447 KH domain//Exosome component EXOSC1/CSL4 -- -- GO:0003723 RNA binding GO:0000178 exosome (RNase complex) KOG3013 Exosomal 3'-5' exoribonuclease complex, subunit Rrp4 Cluster-8309.21745 BP_3 5.49 0.37 998 780636322 XP_011686755.1 451 3.3e-42 PREDICTED: transketolase-like protein 2 isoform X2 [Wasmannia auropunctata] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q2NL26 361 3.7e-33 Transketolase-like protein 1 OS=Bos taurus GN=TKTL1 PE=2 SV=1 PF02780//PF01234 Transketolase, C-terminal domain//NNMT/PNMT/TEMT family GO:0008152 metabolic process GO:0008168//GO:0003824 methyltransferase activity//catalytic activity -- -- KOG0523 Transketolase Cluster-8309.21747 BP_3 3319.05 77.72 2350 642911769 XP_967219.2 2576 3.0e-288 PREDICTED: transketolase-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q9D4D4 1885 1.7e-209 Transketolase-like protein 2 OS=Mus musculus GN=Tktl2 PE=2 SV=1 PF00676//PF02780//PF02775//PF13292 Dehydrogenase E1 component//Transketolase, C-terminal domain//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//1-deoxy-D-xylulose-5-phosphate synthase GO:0006694//GO:0016114//GO:0008152 steroid biosynthetic process//terpenoid biosynthetic process//metabolic process GO:0008661//GO:0030976//GO:0016624//GO:0003824 1-deoxy-D-xylulose-5-phosphate synthase activity//thiamine pyrophosphate binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity -- -- KOG0523 Transketolase Cluster-8309.21749 BP_3 23.44 0.35 3512 478257725 ENN77868.1 1833 6.5e-202 hypothetical protein YQE_05546, partial [Dendroctonus ponderosae]>gi|546677692|gb|ERL88486.1| hypothetical protein D910_05872 [Dendroctonus ponderosae] -- -- -- -- -- K13578 BMPR1B, ALK6 bone morphogenetic protein receptor type-1B http://www.genome.jp/dbget-bin/www_bget?ko:K13578 O00238 1362 1.1e-148 Bone morphogenetic protein receptor type-1B OS=Homo sapiens GN=BMPR1B PE=1 SV=1 PF01064//PF15048//PF08091//PF00069//PF06293//PF07714//PF08515 Activin types I and II receptor domain//Organic solute transporter subunit beta protein//Spider insecticidal peptide//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Transforming growth factor beta type I GS-motif GO:0007178//GO:0009405//GO:0009069//GO:0006468//GO:0006810//GO:0015721//GO:0016310 transmembrane receptor protein serine/threonine kinase signaling pathway//pathogenesis//serine family amino acid metabolic process//protein phosphorylation//transport//bile acid and bile salt transport//phosphorylation GO:0005524//GO:0005215//GO:0046982//GO:0016773//GO:0004675//GO:0004672 ATP binding//transporter activity//protein heterodimerization activity//phosphotransferase activity, alcohol group as acceptor//transmembrane receptor protein serine/threonine kinase activity//protein kinase activity GO:0005886//GO:0005576//GO:0016020 plasma membrane//extracellular region//membrane -- -- Cluster-8309.2175 BP_3 4.00 1.02 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21750 BP_3 21.89 1.03 1319 546672885 ERL84608.1 618 1.9e-61 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 410 1.0e-38 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF00108 Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.21751 BP_3 47.90 1.30 2071 478250506 ENN71001.1 872 1.0e-90 hypothetical protein YQE_12401, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4F753 368 1.2e-33 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF00326//PF07859//PF03376//PF03403//PF02230//PF01764 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Adenovirus E3B protein//Platelet-activating factor acetylhydrolase, isoform II//Phospholipase/Carboxylesterase//Lipase (class 3) GO:0016042//GO:0006508//GO:0046486//GO:0008152//GO:0006629 lipid catabolic process//proteolysis//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0008236//GO:0003847//GO:0016787 serine-type peptidase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0016020//GO:0008247 membrane//1-alkyl-2-acetylglycerophosphocholine esterase complex KOG1552 Predicted alpha/beta hydrolase Cluster-8309.21754 BP_3 94.02 2.04 2510 642923611 XP_972526.2 1317 3.1e-142 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X1 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.07203e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 1070 5.7e-115 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.21755 BP_3 1817.45 16.08 5739 270004842 EFA01290.1 2631 3.1e-294 hypothetical protein TcasGA2_TC002984 [Tribolium castaneum] 642915987 XM_008192623.1 178 2.93443e-85 PREDICTED: Tribolium castaneum uncharacterized LOC660816 (LOC660816), mRNA -- -- -- -- P34528 699 1.4e-71 Putative serine protease K12H4.7 OS=Caenorhabditis elegans GN=K12H4.7 PE=3 SV=2 PF05577//PF15757//PF08437 Serine carboxypeptidase S28//Amelotin//Glycosyl transferase family 8 C-terminal GO:0070175//GO:0042475//GO:0009103//GO:0006508 positive regulation of enamel mineralization//odontogenesis of dentin-containing tooth//lipopolysaccharide biosynthetic process//proteolysis GO:0008918//GO:0008236 lipopolysaccharide 3-alpha-galactosyltransferase activity//serine-type peptidase activity -- -- KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.21759 BP_3 1.00 0.84 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21761 BP_3 10.77 0.88 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21766 BP_3 10.27 0.37 1637 315570560 ADU33284.1 1742 1.1e-191 glycoside hydrolase family protein 48 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P50899 1348 2.1e-147 Exoglucanase B OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) GN=cbhB PE=1 SV=1 PF02011 Glycosyl hydrolase family 48 GO:0005985//GO:0005982//GO:0005975//GO:0030245 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process//cellulose catabolic process GO:0004553//GO:0008810 hydrolase activity, hydrolyzing O-glycosyl compounds//cellulase activity -- -- -- -- Cluster-8309.21769 BP_3 358.59 10.18 1989 557160153 CDJ27266.1 145 2.0e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 9.0e-07 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21770 BP_3 121.45 2.29 2853 557160153 CDJ27266.1 145 2.8e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.3e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21771 BP_3 21.65 0.44 2662 557160153 CDJ27266.1 145 2.7e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.2e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21774 BP_3 16.33 0.88 1186 270015247 EFA11695.1 667 3.5e-67 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21775 BP_3 7.00 0.95 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21780 BP_3 12.00 1.70 632 -- -- -- -- -- 19919546 AF479105.1 261 2.2333e-132 Juglans nigra 26S ribosomal RNA gene, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21781 BP_3 32.00 1.91 1099 817058348 XP_012250632.1 665 5.5e-67 PREDICTED: muscle-specific protein 20 [Athalia rosae] 817207248 XM_012424179.1 50 7.83159e-15 PREDICTED: Orussus abietinus muscle-specific protein 20 (LOC105699307), mRNA -- -- -- -- P14318 609 7.1e-62 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.21783 BP_3 18.00 1.20 1014 642931615 XP_008196657.1 290 1.6e-23 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Tribolium castaneum] 807033681 XM_004529871.2 62 1.53802e-21 PREDICTED: Ceratitis capitata DNA-directed RNA polymerases I, II, and III subunit RPABC4 (LOC101457024), mRNA K03009 RPB12, POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 http://www.genome.jp/dbget-bin/www_bget?ko:K03009 Q3ZBC0 236 1.2e-18 DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Bos taurus GN=POLR2K PE=3 SV=1 PF01155//PF03604 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//DNA directed RNA polymerase, 7 kDa subunit GO:0006206//GO:0006351//GO:0006464//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//cellular protein modification process//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0016151 DNA binding//DNA-directed RNA polymerase activity//nickel cation binding GO:0005730 nucleolus KOG3507 DNA-directed RNA polymerase, subunit RPB7.0 Cluster-8309.21784 BP_3 5.00 0.57 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21787 BP_3 136.00 6.18 1352 642938159 XP_008199788.1 242 7.6e-18 PREDICTED: uncharacterized protein LOC103314749 [Tribolium castaneum]>gi|270016493|gb|EFA12939.1| hypothetical protein TcasGA2_TC010486 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478//PF06156 Prominin//Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.21798 BP_3 64.86 1.44 2469 672273128 KFG45225.1 147 1.4e-06 IgA-specific metalloendopeptidase [Toxoplasma gondii GAB2-2007-GAL-DOM2] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2180 BP_3 9.00 4.06 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21801 BP_3 13.24 2.32 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21802 BP_3 338.45 4.48 3933 642935202 XP_008199688.1 1886 5.2e-208 PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|642935204|ref|XP_008199689.1| PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|270014185|gb|EFA10633.1| hypothetical protein TcasGA2_TC016270 [Tribolium castaneum] 642935203 XM_008201467.1 297 1.41389e-151 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 967 7.8e-103 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21805 BP_3 211.68 1.60 6651 91094503 XP_971555.1 2926 0.0e+00 PREDICTED: tyrosine-protein kinase Fps85D isoform X2 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1542 2.8e-169 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF10541//PF09432//PF00346//PF05090//PF00069//PF07714 Nuclear envelope localisation domain//Tho complex subunit THP2//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Vitamin K-dependent gamma-carboxylase//Protein kinase domain//Protein tyrosine kinase GO:0055114//GO:0006368//GO:0006406//GO:0017187//GO:0006468 oxidation-reduction process//transcription elongation from RNA polymerase II promoter//mRNA export from nucleus//peptidyl-glutamic acid carboxylation//protein phosphorylation GO:0008488//GO:0004672//GO:0048038//GO:0005524//GO:0016651//GO:0051287 gamma-glutamyl carboxylase activity//protein kinase activity//quinone binding//ATP binding//oxidoreductase activity, acting on NAD(P)H//NAD binding GO:0000446//GO:0016021 nucleoplasmic THO complex//integral component of membrane KOG0194 Protein tyrosine kinase Cluster-8309.21806 BP_3 137.36 2.68 2762 642937838 XP_008200322.1 1804 1.2e-198 PREDICTED: tyrosine-protein kinase Fps85D isoform X1 [Tribolium castaneum]>gi|270000733|gb|EEZ97180.1| hypothetical protein TcasGA2_TC004367 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1166 4.6e-126 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF00435 Spectrin repeat GO:0006468 protein phosphorylation GO:0005515//GO:0004713//GO:0005524 protein binding//protein tyrosine kinase activity//ATP binding -- -- KOG0194 Protein tyrosine kinase Cluster-8309.21809 BP_3 93.10 3.47 1586 478258611 ENN78661.1 351 2.1e-30 hypothetical protein YQE_04833, partial [Dendroctonus ponderosae]>gi|546685768|gb|ERL95217.1| hypothetical protein D910_12484 [Dendroctonus ponderosae] 752872390 XM_011255128.1 52 8.81418e-16 PREDICTED: Camponotus floridanus endocuticle structural glycoprotein SgAbd-1-like (LOC105249568), mRNA -- -- -- -- Q7M4F4 231 6.9e-18 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21811 BP_3 36.00 1.50 1446 91080935 XP_974194.1 892 3.5e-93 PREDICTED: CD9 antigen [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26499 166 2.2e-10 23 kDa integral membrane protein OS=Schistosoma haematobium PE=2 SV=1 PF04103//PF05767//PF00335 CD20-like family//Poxvirus virion envelope protein A14//Tetraspanin family -- -- -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-8309.21813 BP_3 26.42 1.12 1432 91095123 XP_970890.1 564 3.7e-55 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] 768425109 XM_011555236.1 42 2.87565e-10 PREDICTED: Plutella xylostella zinc finger protein 253-like (LOC105384939), transcript variant X2, mRNA -- -- -- -- D2WKD9 430 5.3e-41 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF02229 short chain dehydrogenase//Transcriptional Coactivator p15 (PC4) GO:0006355//GO:0008152 regulation of transcription, DNA-templated//metabolic process GO:0003677//GO:0003713//GO:0016491 DNA binding//transcription coactivator activity//oxidoreductase activity GO:0005667 transcription factor complex -- -- Cluster-8309.21814 BP_3 111.00 8.88 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21816 BP_3 32.41 1.43 1382 646708358 KDR14705.1 318 1.2e-26 Vascular endothelial growth factor receptor 2 [Zootermopsis nevadensis] -- -- -- -- -- K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 Q8JFR5 243 2.5e-19 Mast/stem cell growth factor receptor kita OS=Danio rerio GN=kita PE=2 SV=2 PF15352//PF00069//PF07714 Susceptibility to monomelic amyotrophy//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0007052//GO:0031122//GO:0035058 protein phosphorylation//mitotic spindle organization//cytoplasmic microtubule organization//nonmotile primary cilium assembly GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0005813//GO:0097546 centrosome//ciliary base KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.2182 BP_3 17.00 0.98 1131 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21822 BP_3 22.75 0.57 2208 91089397 XP_974004.1 1468 8.6e-160 PREDICTED: pyridoxal-dependent decarboxylase domain-containing protein 1 [Tribolium castaneum]>gi|270011423|gb|EFA07871.1| hypothetical protein TcasGA2_TC005445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K01 445 1.5e-42 Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Mus musculus GN=Pdxdc1 PE=1 SV=2 PF00964 Elicitin GO:0009405//GO:0006952//GO:0019752 pathogenesis//defense response//carboxylic acid metabolic process GO:0016831//GO:0030170 carboxy-lyase activity//pyridoxal phosphate binding GO:0005576 extracellular region -- -- Cluster-8309.21824 BP_3 41.71 0.53 4050 642916519 XP_008191075.1 1501 2.3e-163 PREDICTED: potassium voltage-gated channel protein Shaker isoform X5 [Tribolium castaneum] 642916512 XM_008192850.1 706 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X2, mRNA K05318 KCNAN potassium voltage-gated channel Shaker-related subfamily A, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05318 P08510 1355 8.2e-148 Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.21826 BP_3 5.00 0.32 1037 546683574 ERL93372.1 588 4.4e-58 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 436 7.7e-42 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.2183 BP_3 63.50 1.08 3138 189237437 XP_001815618.1 722 3.9e-73 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWP5 313 4.3e-27 Alpha-tocopherol transfer protein OS=Mus musculus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21831 BP_3 201.11 4.47 2459 270010746 EFA07194.1 906 1.4e-94 hypothetical protein TcasGA2_TC010200 [Tribolium castaneum] -- -- -- -- -- K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 197 9.4e-14 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21832 BP_3 4.00 1.49 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21835 BP_3 29.00 0.71 2274 91090025 XP_967532.1 1264 4.0e-136 PREDICTED: homeobox protein slou [Tribolium castaneum]>gi|270013697|gb|EFA10145.1| hypothetical protein TcasGA2_TC012332 [Tribolium castaneum] 690022837 LM530855.1 37 2.77382e-07 Mesocestoides corti genome assembly M_corti_Specht_Voge ,scaffold MCOS_scaffold0000388 K09309 NKX1 homeobox protein Nkx-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09309 P22807 504 2.2e-49 Homeobox protein slou OS=Drosophila melanogaster GN=slou PE=2 SV=1 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.21836 BP_3 9.00 5.28 371 91094083 XP_970629.1 347 1.4e-30 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270016176|gb|EFA12624.1| hypothetical protein TcasGA2_TC010257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBV9 215 1.2e-16 Dehydrogenase/reductase SDR family member 11 OS=Bos taurus GN=DHRS11 PE=2 SV=1 PF01272//PF00106//PF01073//PF01370 Transcription elongation factor, GreA/GreB, C-term//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0032784//GO:0008210//GO:0008152//GO:0055114//GO:0006694//GO:0008209//GO:0008207 regulation of DNA-templated transcription, elongation//estrogen metabolic process//metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0003677//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//DNA binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.21839 BP_3 59.12 2.33 1513 642928334 XP_008195539.1 512 4.2e-49 PREDICTED: lysozyme-like [Tribolium castaneum] 332373991 BT127175.1 50 1.08652e-14 Dendroctonus ponderosae clone DPO0418_A10 unknown mRNA K01185 E3.2.1.17 lysozyme http://www.genome.jp/dbget-bin/www_bget?ko:K01185 P48816 328 3.7e-29 Lysozyme OS=Bombyx mori PE=1 SV=1 PF01160 Vertebrate endogenous opioids neuropeptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.2184 BP_3 16.00 0.61 1554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21843 BP_3 492.00 12.39 2205 91090075 XP_969798.1 1544 1.3e-168 PREDICTED: glucoside xylosyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K13676 GXYLT UDP-xylose:glucoside alpha-1,3-xylosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13676 Q810K9 950 4.1e-101 Glucoside xylosyltransferase 2 OS=Mus musculus GN=Gxylt2 PE=2 SV=1 PF01501 Glycosyl transferase family 8 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.21844 BP_3 240.58 1.13 10533 270006380 EFA02828.1 2538 3.4e-283 insulin-like growth factor receptor [Tribolium castaneum]>gi|570932717|gb|AHF20215.1| insulin like receptor 2 [Tribolium castaneum] 471364329 XM_004372657.1 83 3.48752e-32 PREDICTED: Trichechus manatus latirostris insulin-like growth factor 1 receptor (LOC101355333), mRNA K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q60751 1871 3.1e-207 Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 PF16656//PF08727//PF00757//PF00909//PF00041//PF00069//PF07714 Purple acid Phosphatase, N-terminal domain//Poliovirus 3A protein like//Furin-like cysteine rich region//Ammonium Transporter Family//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0019497//GO:0015696//GO:0006144//GO:0006508//GO:0006771//GO:0007169 protein phosphorylation//hexachlorocyclohexane metabolic process//ammonium transport//purine nucleobase metabolic process//proteolysis//riboflavin metabolic process//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0008519//GO:0003993//GO:0005515//GO:0003968//GO:0004197//GO:0004714//GO:0017111//GO:0004672//GO:0046872 ATP binding//ammonium transmembrane transporter activity//acid phosphatase activity//protein binding//RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//transmembrane receptor protein tyrosine kinase activity//nucleoside-triphosphatase activity//protein kinase activity//metal ion binding GO:0016020//GO:0031379 membrane//RNA-directed RNA polymerase complex KOG3796 Ammonium transporter RHBG Cluster-8309.21846 BP_3 611.00 10.80 3019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21847 BP_3 8.00 4.54 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21848 BP_3 201.88 1.71 5980 642926648 XP_970736.2 988 1.1e-103 PREDICTED: elongator complex protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGK7 484 1.2e-46 Putative elongator complex protein 1 OS=Drosophila melanogaster GN=Elp1 PE=1 SV=2 PF00637 Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport -- -- -- -- KOG1920 IkappaB kinase complex, IKAP component Cluster-8309.21850 BP_3 2360.62 27.67 4404 642923337 XP_008193707.1 2964 0.0e+00 PREDICTED: uncharacterized protein LOC103313102 [Tribolium castaneum]>gi|270007619|gb|EFA04067.1| hypothetical protein TcasGA2_TC014301 [Tribolium castaneum] 170035242 XM_001845428.1 49 1.15454e-13 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- P22792 295 7.3e-25 Carboxypeptidase N subunit 2 OS=Homo sapiens GN=CPN2 PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.21854 BP_3 8.00 0.51 1052 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21857 BP_3 13.41 0.34 2204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21859 BP_3 4.89 1.07 512 741829858 AJA91073.1 501 2.7e-48 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 380 1.2e-35 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.2186 BP_3 1.00 0.35 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02020 eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21864 BP_3 29.53 0.35 4374 642910515 XP_971774.3 2330 1.9e-259 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] 642910514 XM_966681.3 50 3.18799e-14 PREDICTED: Tribolium castaneum leucine-rich repeats and immunoglobulin-like domains protein 2 (LOC660451), transcript variant X2, mRNA -- -- -- -- Q52KR2 1432 1.0e-156 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Mus musculus GN=Lrig2 PE=1 SV=1 PF06667//PF13895//PF02924//PF05790 Phage shock protein B//Immunoglobulin domain//Bacteriophage lambda head decoration protein D//Immunoglobulin C2-set domain GO:0009271//GO:0007155//GO:0006355 phage shock//cell adhesion//regulation of transcription, DNA-templated GO:0005515 protein binding GO:0019028//GO:0016021 viral capsid//integral component of membrane -- -- Cluster-8309.21865 BP_3 27.31 1.07 1522 642910515 XP_971774.3 297 3.6e-24 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q52KR2 210 1.8e-15 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Mus musculus GN=Lrig2 PE=1 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21867 BP_3 1.00 0.55 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21872 BP_3 892.72 7.24 6231 642924039 XP_008193981.1 2263 1.6e-251 PREDICTED: synaptic vesicle 2-related protein [Tribolium castaneum] 642924038 XM_008195759.1 402 0 PREDICTED: Tribolium castaneum synaptic vesicle 2-related protein (LOC100142592), mRNA -- -- -- -- Q9Z2I7 1317 3.2e-143 Synaptic vesicle 2-related protein OS=Rattus norvegicus GN=Svop PE=1 SV=1 PF13409//PF13417//PF00701//PF00083//PF02798//PF07690 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Dihydrodipicolinate synthetase family//Sugar (and other) transporter//Glutathione S-transferase, N-terminal domain//Major Facilitator Superfamily GO:0008152//GO:0055085 metabolic process//transmembrane transport GO:0022857//GO:0005515//GO:0016829 transmembrane transporter activity//protein binding//lyase activity GO:0016021 integral component of membrane KOG0253 Synaptic vesicle transporter SV2 (major facilitator superfamily) Cluster-8309.21874 BP_3 53.00 3.95 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21877 BP_3 372.64 15.55 1447 91083615 XP_969779.1 391 4.3e-35 PREDICTED: small nuclear ribonucleoprotein F [Tribolium castaneum]>gi|270007843|gb|EFA04291.1| hypothetical protein TcasGA2_TC014582 [Tribolium castaneum] -- -- -- -- -- K11098 SNRPF, SMF small nuclear ribonucleoprotein F http://www.genome.jp/dbget-bin/www_bget?ko:K11098 Q24297 341 1.1e-30 Small nuclear ribonucleoprotein F OS=Drosophila melanogaster GN=SmF PE=1 SV=2 -- -- GO:0006396 RNA processing -- -- GO:0005634 nucleus KOG3482 Small nuclear ribonucleoprotein (snRNP) SMF Cluster-8309.21880 BP_3 234.00 19.17 880 91083283 XP_974418.1 655 6.4e-66 PREDICTED: pre-rRNA-processing protein esf2 [Tribolium castaneum]>gi|270007726|gb|EFA04174.1| hypothetical protein TcasGA2_TC014423 [Tribolium castaneum] -- -- -- -- -- K14785 ESF2, ABT1 ESF2/ABP1 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K14785 O74362 312 1.6e-27 Pre-rRNA-processing protein esf2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=esf2 PE=1 SV=1 PF00076//PF05985 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ethanolamine ammonia-lyase light chain (EutC) GO:0006520 cellular amino acid metabolic process GO:0008851//GO:0000166//GO:0003676 ethanolamine ammonia-lyase activity//nucleotide binding//nucleic acid binding GO:0009350 ethanolamine ammonia-lyase complex KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif) Cluster-8309.21883 BP_3 17.60 0.35 2720 827549501 XP_012546855.1 292 2.4e-23 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.21889 BP_3 391.95 15.34 1523 91086841 XP_974159.1 749 1.4e-76 PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum]>gi|642929084|ref|XP_008195684.1| PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum] -- -- -- -- -- K11205 GCLM glutamate--cysteine ligase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11205 P48508 336 4.4e-30 Glutamate--cysteine ligase regulatory subunit OS=Rattus norvegicus GN=Gclm PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3023 Glutamate-cysteine ligase regulatory subunit Cluster-8309.21891 BP_3 99.53 10.58 745 749773946 XP_011142301.1 194 1.5e-12 PREDICTED: uncharacterized protein LOC105184888 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21893 BP_3 94.00 6.56 982 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21894 BP_3 16.21 0.34 2586 642922865 XP_008200429.1 1388 1.9e-150 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum]>gi|642922867|ref|XP_008200430.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1045 4.6e-112 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00004//PF13304//PF01926//PF00664//PF08477//PF04548//PF00236//PF03193//PF00005 ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase//AIG1 family//Glycoprotein hormone//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0007165//GO:0055085//GO:0007264 transport//signal transduction//transmembrane transport//small GTPase mediated signal transduction GO:0005179//GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887 hormone activity//GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.21896 BP_3 294.00 17.80 1088 642934666 XP_008197759.1 385 1.6e-34 PREDICTED: partitioning defective 3 homolog isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21897 BP_3 309.26 3.05 5179 642934658 XP_008197755.1 4108 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.05087e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 446 2.7e-42 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF08727//PF01702//PF00595 Poliovirus 3A protein like//Queuine tRNA-ribosyltransferase//PDZ domain (Also known as DHR or GLGF) GO:0008616//GO:0006144//GO:0006508//GO:0006400 queuosine biosynthetic process//purine nucleobase metabolic process//proteolysis//tRNA modification GO:0008479//GO:0005515//GO:0003968//GO:0004197//GO:0017111 queuine tRNA-ribosyltransferase activity//protein binding//RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.219 BP_3 7.00 0.43 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21901 BP_3 17.00 0.43 2185 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21903 BP_3 52.97 2.87 1182 751657284 AJF94901.1 1074 2.2e-114 C1 family cathepsin B33 [Tenebrio molitor] 543271545 XM_005424950.1 99 4.86382e-42 PREDICTED: Geospiza fortis cathepsin B (CTSB), mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 965 4.0e-103 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF03320//PF08127//PF00112//PF03051 Bacterial fructose-1,6-bisphosphatase, glpX-encoded//Peptidase family C1 propeptide//Papain family cysteine protease//Peptidase C1-like family GO:0006094//GO:0015976//GO:0006508//GO:0006071//GO:0050790//GO:0006013//GO:0006000//GO:0006096//GO:0006098 gluconeogenesis//carbon utilization//proteolysis//glycerol metabolic process//regulation of catalytic activity//mannose metabolic process//fructose metabolic process//glycolytic process//pentose-phosphate shunt GO:0008234//GO:0004197//GO:0042132 cysteine-type peptidase activity//cysteine-type endopeptidase activity//fructose 1,6-bisphosphate 1-phosphatase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.21906 BP_3 156.60 2.16 3786 478251121 ENN71597.1 2600 8.0e-291 hypothetical protein YQE_11696, partial [Dendroctonus ponderosae] 543338846 XM_005516267.1 47 1.28218e-12 PREDICTED: Pseudopodoces humilis mitochondrial intermediate peptidase (MIPEP), mRNA K01410 MIPEP mitochondrial intermediate peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01410 Q99797 1794 9.5e-199 Mitochondrial intermediate peptidase OS=Homo sapiens GN=MIPEP PE=1 SV=2 PF08533//PF01432 Beta-galactosidase C-terminal domain//Peptidase family M3 GO:0006027//GO:0006012//GO:0046486//GO:0006687//GO:0006508 glycosaminoglycan catabolic process//galactose metabolic process//glycerolipid metabolic process//glycosphingolipid metabolic process//proteolysis GO:0004565//GO:0004222 beta-galactosidase activity//metalloendopeptidase activity GO:0009341 beta-galactosidase complex KOG2090 Metalloendopeptidase family - mitochondrial intermediate peptidase Cluster-8309.21909 BP_3 5.00 0.55 727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21913 BP_3 15.49 0.75 1284 674304042 AIL23552.1 727 4.2e-74 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q2NL00 386 6.0e-36 Glutathione S-transferase theta-1 OS=Bos taurus GN=GSTT1 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0867 Glutathione S-transferase Cluster-8309.21915 BP_3 96.92 2.16 2459 642938252 XP_008198130.1 1486 7.8e-162 PREDICTED: disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [Tribolium castaneum] 642938255 XM_008199910.1 227 7.19679e-113 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 Q8JIY1 635 1.5e-64 Disintegrin and metalloproteinase domain-containing protein 10 OS=Xenopus laevis GN=adam10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.21919 BP_3 10.00 0.95 801 478258771 ENN78795.1 215 6.1e-15 hypothetical protein YQE_04751, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21922 BP_3 31.61 0.32 5030 642937760 XP_008198934.1 1304 2.0e-140 PREDICTED: mortality factor 4-like protein 1 [Tribolium castaneum]>gi|270001152|gb|EEZ97599.1| hypothetical protein TcasGA2_TC011468 [Tribolium castaneum] 807018879 XM_004519732.2 70 2.79729e-25 PREDICTED: Ceratitis capitata nuA4 complex subunit EAF3 homolog (LOC101448544), mRNA K11339 MORF4L1, MRG15, EAF3 mortality factor 4-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11339 Q6AYU1 950 9.3e-101 Mortality factor 4-like protein 1 OS=Rattus norvegicus GN=Morf4l1 PE=2 SV=1 PF05485//PF01080 THAP domain//Presenilin -- -- GO:0004190//GO:0003676 aspartic-type endopeptidase activity//nucleic acid binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.21925 BP_3 44.00 1.50 1705 642920590 XP_008192477.1 919 3.0e-96 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 516 6.7e-51 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.21926 BP_3 71.41 1.32 2900 270003747 EFA00195.1 1464 3.3e-159 hypothetical protein TcasGA2_TC003020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 837 6.8e-88 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.21934 BP_3 35.64 0.81 2421 546682217 ERL92178.1 1152 4.1e-123 hypothetical protein D910_09498 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q02942 356 3.4e-32 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21935 BP_3 16.14 0.86 1200 157131660 XP_001655912.1 535 7.2e-52 AAEL012172-PA [Aedes aegypti]>gi|157131662|ref|XP_001655913.1| AAEL012179-PA [Aedes aegypti]>gi|122127167|sp|Q16MW6.1|MTAP_AEDAE RecName: Full=S-methyl-5'-thioadenosine phosphorylase; AltName: Full=5'-methylthioadenosine phosphorylase; Short=MTA phosphorylase; Short=MTAP; Short=MTAPase [Aedes aegypti]>gi|108871452|gb|EAT35677.1| AAEL012172-PA [Aedes aegypti]>gi|108871453|gb|EAT35678.1| AAEL012179-PA [Aedes aegypti] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q16MW6 535 2.9e-53 S-methyl-5'-thioadenosine phosphorylase OS=Aedes aegypti GN=AAEL012172 PE=3 SV=1 PF12422//PF01048 Condensin II non structural maintenance of chromosomes subunit//Phosphorylase superfamily GO:0043094//GO:1901566//GO:0009116//GO:0044271 cellular metabolic compound salvage//organonitrogen compound biosynthetic process//nucleoside metabolic process//cellular nitrogen compound biosynthetic process GO:0003824//GO:0016763 catalytic activity//transferase activity, transferring pentosyl groups GO:0005634//GO:0044424 nucleus//intracellular part KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.21936 BP_3 113.00 18.63 584 91088177 XP_972343.1 426 1.5e-39 PREDICTED: nuclear nucleic acid-binding protein C1D [Tribolium castaneum]>gi|270012131|gb|EFA08579.1| hypothetical protein TcasGA2_TC006234 [Tribolium castaneum] -- -- -- -- -- K12592 C1D, LRP1 exosome complex protein LRP1 http://www.genome.jp/dbget-bin/www_bget?ko:K12592 Q3KPR1 180 2.1e-12 Nuclear nucleic acid-binding protein C1D OS=Xenopus laevis GN=c1d PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21937 BP_3 88.68 3.12 1660 642915229 XP_008190531.1 1140 7.0e-122 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 676 1.8e-69 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21938 BP_3 77.95 2.90 1588 642915229 XP_008190531.1 2008 1.5e-222 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 1135 1.0e-122 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.21940 BP_3 23.31 0.63 2073 642916810 XP_967695.2 1375 4.9e-149 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 985 3.4e-105 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0005515//GO:0042301 protein binding//phosphate ion binding GO:0009523//GO:0016020 photosystem II//membrane KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.21944 BP_3 14.00 0.80 1132 642924471 XP_972019.2 684 3.6e-69 PREDICTED: SOX domain-containing protein dichaete [Tribolium castaneum] 572297918 XM_006615069.1 90 4.69057e-37 PREDICTED: Apis dorsata transcription factor Sox-21-B-like (LOC102672887), mRNA K09267 SOX1S transcription factor SOX1/3/14/21 (SOX group B) http://www.genome.jp/dbget-bin/www_bget?ko:K09267 Q24533 425 1.6e-40 SOX domain-containing protein dichaete OS=Drosophila melanogaster GN=D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.21946 BP_3 14.00 0.31 2478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21947 BP_3 442.65 2.61 8462 642935561 XP_008198059.1 3443 0.0e+00 PREDICTED: glutamate receptor-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15283 SLC35E1 solute carrier family 35, member E1 http://www.genome.jp/dbget-bin/www_bget?ko:K15283 Q9VR50 1070 1.9e-114 Solute carrier family 35 member E1 homolog OS=Drosophila melanogaster GN=CG14621 PE=2 SV=1 PF01783//PF09165//PF00892//PF08088//PF00595//PF13180 Ribosomal L32p protein family//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//EamA-like transporter family//Conotoxin I-superfamily//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006119//GO:0006412//GO:0009405//GO:0055114//GO:0015992//GO:0042254//GO:0006118 oxidative phosphorylation//translation//pathogenesis//oxidation-reduction process//proton transport//ribosome biogenesis//obsolete electron transport GO:0008121//GO:0005515//GO:0003735 ubiquinol-cytochrome-c reductase activity//protein binding//structural constituent of ribosome GO:0016021//GO:0015934//GO:0005840//GO:0005576//GO:0016020 integral component of membrane//large ribosomal subunit//ribosome//extracellular region//membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.21949 BP_3 1.00 16.18 231 570341982 AHE77387.1 176 5.9e-11 heat shock protein 70, partial [Lissorhoptrus oryzophilus] 215254405 FJ177313.1 60 4.04256e-21 Aedes aegypti heat shock 70 Ca (Hsp70Ca) gene, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 161 1.3e-10 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.21951 BP_3 42.00 5.78 642 646720800 KDR22397.1 603 5.0e-60 MORN repeat-containing protein 4 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q0VD26 376 4.3e-35 MORN repeat-containing protein 4 OS=Bos taurus GN=MORN4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.21952 BP_3 29.72 0.42 3676 642917889 XP_008191371.1 1627 5.2e-178 PREDICTED: regulator of chromosome condensation [Tribolium castaneum]>gi|642917891|ref|XP_008191372.1| PREDICTED: regulator of chromosome condensation [Tribolium castaneum] -- -- -- -- -- K11493 RCC1 regulator of chromosome condensation http://www.genome.jp/dbget-bin/www_bget?ko:K11493 P25183 890 6.2e-94 Regulator of chromosome condensation OS=Xenopus laevis GN=rcc1 PE=2 SV=1 PF03989//PF01405 DNA gyrase C-terminal domain, beta-propeller//Photosystem II reaction centre T protein GO:0006265//GO:0015979 DNA topological change//photosynthesis GO:0003677//GO:0005524//GO:0003916 DNA binding//ATP binding//DNA topoisomerase activity GO:0005694//GO:0016020//GO:0009539//GO:0009523 chromosome//membrane//photosystem II reaction center//photosystem II KOG1426 FOG: RCC1 domain Cluster-8309.21953 BP_3 423.00 7.70 2939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21954 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21955 BP_3 863.84 10.80 4147 91085441 XP_969050.1 1854 2.8e-204 PREDICTED: wee1-like protein kinase [Tribolium castaneum] -- -- -- -- -- K06632 WEE1 wee1-like protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06632 P47810 1142 4.2e-123 Wee1-like protein kinase OS=Mus musculus GN=Wee1 PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0601 Cyclin-dependent kinase WEE1 Cluster-8309.21957 BP_3 88.00 3.08 1670 478252830 ENN73219.1 164 1.0e-08 hypothetical protein YQE_10116, partial [Dendroctonus ponderosae]>gi|546672035|gb|ERL84091.1| hypothetical protein D910_01428 [Dendroctonus ponderosae]>gi|546672044|gb|ERL84097.1| hypothetical protein D910_01434 [Dendroctonus ponderosae]>gi|546672161|gb|ERL84154.1| hypothetical protein D910_01520 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02059//PF07548 Interleukin-3//Chlamydia polymorphic membrane protein middle domain GO:0006955//GO:0008283//GO:0040007//GO:0007165 immune response//cell proliferation//growth//signal transduction GO:0005135//GO:0008083 interleukin-3 receptor binding//growth factor activity GO:0005894//GO:0005576//GO:0019867 interleukin-3 receptor complex//extracellular region//outer membrane -- -- Cluster-8309.21958 BP_3 41.00 0.85 2614 642928601 XP_008199973.1 977 8.7e-103 PREDICTED: protein distal antenna [Tribolium castaneum]>gi|270011136|gb|EFA07584.1| distal antenna [Tribolium castaneum] 642928600 XM_008201751.1 89 3.96127e-36 PREDICTED: Tribolium castaneum protein distal antenna (LOC103314807), mRNA -- -- -- -- B0X560 266 1.0e-21 Protein distal antenna OS=Culex quinquefasciatus GN=dan PE=3 SV=1 PF04218//PF01527 CENP-B N-terminal DNA-binding domain//Transposase GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-8309.21963 BP_3 60.35 0.42 7239 642925566 XP_008194602.1 2381 3.8e-265 PREDICTED: chorion peroxidase-like isoform X1 [Tribolium castaneum]>gi|270009250|gb|EFA05698.1| hypothetical protein TcasGA2_TC015234 [Tribolium castaneum] 817214764 XM_012428160.1 59 5.25378e-19 PREDICTED: Orussus abietinus uncharacterized LOC105701425 (LOC105701425), mRNA -- -- -- -- Q9VEG6 910 5.8e-96 Chorion peroxidase OS=Drosophila melanogaster GN=Pxt PE=2 SV=3 -- -- GO:0006979//GO:0006804//GO:0055114 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004601//GO:0020037 peroxidase activity//heme binding -- -- -- -- Cluster-8309.21965 BP_3 21.82 0.33 3438 297595480 ADI48181.1 2154 3.8e-239 membrane alanyl aminopeptidase 1 [Chrysomela tremula] 826418381 XM_012668567.1 35 5.45025e-06 PREDICTED: Monomorium pharaonis uncharacterized LOC105829585 (LOC105829585), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 Q11001 1194 3.2e-129 Membrane alanyl aminopeptidase (Fragment) OS=Manduca sexta PE=1 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.21966 BP_3 34.00 2.83 870 642910796 XP_008193415.1 564 2.3e-55 PREDICTED: homeobox protein ceh-31-like [Tribolium castaneum]>gi|270015153|gb|EFA11601.1| nk homeobox 7 [Tribolium castaneum] 780130236 XM_780913.4 57 7.89638e-19 PREDICTED: Strongylocentrotus purpuratus homeobox protein GBX-2 (LOC580883), mRNA -- -- -- -- P56407 222 4.2e-17 Homeobox protein ceh-9 OS=Caenorhabditis elegans GN=ceh-9 PE=3 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0485 Transcription factor NKX-5.1/HMX1, contains HOX domain Cluster-8309.21967 BP_3 77.00 4.03 1212 642910796 XP_008193415.1 352 1.2e-30 PREDICTED: homeobox protein ceh-31-like [Tribolium castaneum]>gi|270015153|gb|EFA11601.1| nk homeobox 7 [Tribolium castaneum] 831526486 XM_012863970.1 44 1.87293e-11 PREDICTED: Fundulus heteroclitus NK1 homeobox 2 (nkx1-2), mRNA -- -- -- -- -- -- -- -- PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.21968 BP_3 0.21 2.26 241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21969 BP_3 124.15 4.75 1551 91079957 XP_969398.1 796 5.0e-82 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2197 BP_3 41.97 1.08 2171 270001382 EEZ97829.1 1663 2.1e-182 hypothetical protein TcasGA2_TC000197 [Tribolium castaneum] -- -- -- -- -- K01217 IDUA L-iduronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01217 P48441 943 2.6e-100 Alpha-L-iduronidase OS=Mus musculus GN=Idua PE=1 SV=2 PF01229 Glycosyl hydrolases family 39 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21970 BP_3 70.88 0.85 4331 642911734 XP_008200718.1 1162 5.1e-124 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC660336 [Tribolium castaneum] 462310927 APGK01047154.1 60 8.71408e-20 Dendroctonus ponderosae Seq01047164, whole genome shotgun sequence -- -- -- -- Q6PD21 334 2.2e-29 SH2 domain-containing adapter protein B OS=Mus musculus GN=Shb PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21971 BP_3 108.26 48.43 398 530723033 AGT42325.1 611 3.6e-61 skeletal muscle actin 2 [Portunus trituberculatus] 514833854 KC795683.1 362 0 Scylla paramamosain beta-actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P53474 602 1.7e-61 Actin, cytoskeletal 3A OS=Strongylocentrotus purpuratus GN=CYIIIA PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.21973 BP_3 722.30 18.26 2198 642916176 XP_008190917.1 2385 4.0e-266 PREDICTED: transcription factor 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BQ70 1132 3.2e-122 Transcription factor 25 OS=Homo sapiens GN=TCF25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2422 Uncharacterized conserved protein Cluster-8309.21974 BP_3 37.49 1.23 1758 642916176 XP_008190917.1 1200 8.1e-129 PREDICTED: transcription factor 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BQ70 503 2.2e-49 Transcription factor 25 OS=Homo sapiens GN=TCF25 PE=1 SV=1 PF11744 Aluminium activated malate transporter GO:0015743 malate transport -- -- -- -- KOG2422 Uncharacterized conserved protein Cluster-8309.21978 BP_3 9.85 0.81 875 665790563 XP_008560974.1 175 2.9e-10 PREDICTED: pro-resilin [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2198 BP_3 104.19 6.72 1039 22901764 AAN10061.1 145 1.0e-06 Kunitz-like protease inhibitor precursor [Ancylostoma caninum] -- -- -- -- -- -- -- -- -- P10280 151 8.6e-09 Kunitz-type proteinase inhibitor 5 II OS=Anemonia sulcata PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.21980 BP_3 3.00 1.53 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21981 BP_3 55.35 3.67 1018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21986 BP_3 27.00 0.54 2694 91083847 XP_973942.1 361 2.4e-31 PREDICTED: endocuticle structural glycoprotein SgAbd-2 [Tribolium castaneum]>gi|270007939|gb|EFA04387.1| hypothetical protein TcasGA2_TC014685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 269 4.6e-22 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.21988 BP_3 1.00 1.49 310 166947671 ABZ04122.1 315 6.0e-27 putative cuticle protein CP5 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F3 258 1.0e-21 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.21989 BP_3 782.59 16.95 2517 270012119 EFA08567.1 489 3.2e-46 hypothetical protein TcasGA2_TC006222 [Tribolium castaneum] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 193 2.8e-13 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.21990 BP_3 1160.40 24.76 2551 270012119 EFA08567.1 489 3.3e-46 hypothetical protein TcasGA2_TC006222 [Tribolium castaneum] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 193 2.8e-13 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.21994 BP_3 53.00 2.67 1248 546676123 ERL87190.1 674 5.7e-68 hypothetical protein D910_04590 [Dendroctonus ponderosae] -- -- -- -- -- K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 A8XI75 460 1.5e-44 Probable histone-lysine N-methyltransferase set-23 OS=Caenorhabditis briggsae GN=set-23 PE=3 SV=1 PF03871//PF00856//PF05033 RNA polymerase Rpb5, N-terminal domain//SET domain//Pre-SET motif GO:0006351//GO:0006144//GO:0034968//GO:0006479//GO:0006206//GO:0006554 transcription, DNA-templated//purine nucleobase metabolic process//histone lysine methylation//protein methylation//pyrimidine nucleobase metabolic process//lysine catabolic process GO:0003899//GO:0003677//GO:0018024//GO:0005515//GO:0008270 DNA-directed RNA polymerase activity//DNA binding//histone-lysine N-methyltransferase activity//protein binding//zinc ion binding GO:0005634//GO:0005730 nucleus//nucleolus KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing Cluster-8309.21996 BP_3 18.60 0.37 2722 766938860 XP_011501956.1 794 1.5e-81 PREDICTED: uncharacterized protein LOC105365477 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF03505 Sulfatase//Clostridium enterotoxin GO:0008152//GO:0009405 metabolic process//pathogenesis GO:0008484 sulfuric ester hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.21999 BP_3 2127.98 27.11 4075 478261443 ENN80813.1 1898 2.2e-209 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] 462382197 APGK01021748.1 140 2.76552e-64 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 1081 4.9e-116 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.220 BP_3 5.00 0.34 998 270006354 EFA02802.1 355 4.4e-31 female sterile nasrat [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22000 BP_3 57.71 0.70 4273 815796505 XP_012218926.1 1078 2.8e-114 PREDICTED: POU domain, class 6, transcription factor 2 isoform X1 [Linepithema humile] 817056495 XM_012413689.1 172 4.71911e-82 PREDICTED: Athalia rosae POU domain, class 6, transcription factor 1 (LOC105693636), mRNA K09368 POU6F POU domain transcription factor, class 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09368 Q8BJI4 693 5.0e-71 POU domain, class 6, transcription factor 2 OS=Mus musculus GN=Pou6f2 PE=2 SV=1 PF00046//PF01381//PF00157 Homeobox domain//Helix-turn-helix//Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.22002 BP_3 265.91 6.44 2283 478259695 ENN79539.1 904 2.2e-94 hypothetical protein YQE_04002, partial [Dendroctonus ponderosae]>gi|546679825|gb|ERL90217.1| hypothetical protein D910_07570 [Dendroctonus ponderosae] -- -- -- -- -- K05995 pepE dipeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K05995 Q91642 697 9.2e-72 Alpha-aspartyl dipeptidase OS=Xenopus laevis GN=aad-a PE=1 SV=1 PF03575 Peptidase family S51 GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- -- -- Cluster-8309.22003 BP_3 14.94 1.86 679 642920394 XP_008192328.1 230 9.4e-17 PREDICTED: uncharacterized protein LOC103312721 isoform X1 [Tribolium castaneum]>gi|270005235|gb|EFA01683.1| hypothetical protein TcasGA2_TC007257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22005 BP_3 302.71 14.16 1322 270011004 EFA07452.1 1004 3.3e-106 serine protease P91 [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P13582 498 6.3e-49 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.22007 BP_3 25.00 1.43 1135 861627520 KMQ89105.1 1139 6.2e-122 pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P0CT40 326 4.8e-29 Transposon Tf2-9 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-9 PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.22008 BP_3 93.09 1.48 3331 861616833 KMQ86423.1 1250 2.5e-134 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 498 1.6e-48 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF01165//PF00328 Ribosomal protein S21//Histidine phosphatase superfamily (branch 2) GO:0042254//GO:0019497//GO:0006412//GO:0006771 ribosome biogenesis//hexachlorocyclohexane metabolic process//translation//riboflavin metabolic process GO:0003735//GO:0003993 structural constituent of ribosome//acid phosphatase activity GO:0005840 ribosome KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.22010 BP_3 78.34 0.70 5678 383847785 XP_003699533.1 2153 8.2e-239 PREDICTED: serine/threonine-protein phosphatase 5 isoform X1 [Megachile rotundata] 817223205 XM_012431486.1 202 1.32229e-98 PREDICTED: Orussus abietinus serine/threonine-protein phosphatase 5 (LOC105703243), transcript variant X2, mRNA K04460 PPP5C serine/threonine-protein phosphatase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04460 P53041 1825 3.6e-202 Serine/threonine-protein phosphatase 5 OS=Homo sapiens GN=PPP5C PE=1 SV=1 PF13174//PF13181//PF13176//PF13414//PF00515//PF00149//PF13371//PF01553 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Calcineurin-like phosphoesterase//Tetratricopeptide repeat//Acyltransferase GO:0008152 metabolic process GO:0016787//GO:0005515//GO:0016746 hydrolase activity//protein binding//transferase activity, transferring acyl groups -- -- KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.22011 BP_3 3.00 0.34 719 642936747 XP_008198564.1 142 1.6e-06 PREDICTED: protein unc-13 homolog D isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22015 BP_3 213.00 5.76 2075 571330974 AHF27419.1 1176 5.8e-126 putative sugar transporter 5 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A5LGM7 634 1.7e-64 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.22016 BP_3 310.00 13.16 1427 270011401 EFA07849.1 710 4.3e-72 hypothetical protein TcasGA2_TC005419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22017 BP_3 90.75 1.89 2603 91081127 XP_976484.1 546 8.2e-53 PREDICTED: protein maelstrom [Tribolium castaneum]>gi|270006444|gb|EFA02892.1| maelstrom [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0W2W6 332 2.2e-29 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.22020 BP_3 45.13 0.95 2572 478252154 ENN72582.1 1192 1.0e-127 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 P48760 845 7.1e-89 Folylpolyglutamate synthase, mitochondrial OS=Mus musculus GN=Fpgs PE=1 SV=3 PF02875//PF08245 Mur ligase family, glutamate ligase domain//Mur ligase middle domain GO:0009058 biosynthetic process GO:0005524//GO:0016874 ATP binding//ligase activity -- -- KOG2525 Folylpolyglutamate synthase Cluster-8309.22021 BP_3 3.00 0.36 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22024 BP_3 83.00 9.73 703 478259043 ENN78986.1 629 5.3e-63 hypothetical protein YQE_04537, partial [Dendroctonus ponderosae]>gi|478266116|gb|ENN82691.1| hypothetical protein YQE_00938, partial [Dendroctonus ponderosae]>gi|546678356|gb|ERL88989.1| hypothetical protein D910_06367 [Dendroctonus ponderosae] -- -- -- -- -- K13152 ZMAT5 U11/U12 small nuclear ribonucleoprotein 20 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13152 Q9CQR5 265 3.5e-22 Zinc finger matrin-type protein 5 OS=Mus musculus GN=Zmat5 PE=2 SV=1 PF00642//PF06220 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//U1 zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.22033 BP_3 34.00 1.09 1795 91087191 XP_975444.1 735 6.9e-75 PREDICTED: SAGA-associated factor 29 homolog [Tribolium castaneum]>gi|270009566|gb|EFA06014.1| hypothetical protein TcasGA2_TC008842 [Tribolium castaneum] -- -- -- -- -- K11364 SGF29 SAGA-associated factor 29 http://www.genome.jp/dbget-bin/www_bget?ko:K11364 Q9DA08 461 1.7e-44 SAGA-associated factor 29 homolog OS=Mus musculus GN=Ccdc101 PE=2 SV=1 PF11744//PF08702//PF00631 Aluminium activated malate transporter//Fibrinogen alpha/beta chain family//GGL domain GO:0030168//GO:0007186//GO:0007165//GO:0051258//GO:0015743 platelet activation//G-protein coupled receptor signaling pathway//signal transduction//protein polymerization//malate transport GO:0005102//GO:0004871//GO:0030674 receptor binding//signal transducer activity//protein binding, bridging GO:0005577//GO:0005834 fibrinogen complex//heterotrimeric G-protein complex KOG3038 Histone acetyltransferase SAGA associated factor SGF29 Cluster-8309.22034 BP_3 1.00 1.62 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22035 BP_3 1.00 0.68 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22036 BP_3 537.00 14.18 2117 642938754 XP_008199874.1 1325 3.1e-143 PREDICTED: somatostatin-like receptor F_48D10.1 [Tribolium castaneum]>gi|270015914|gb|EFA12362.1| hypothetical protein TcasGA2_TC002068 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDN6 189 6.9e-13 Neuropeptide Y receptor type 2 OS=Gallus gallus GN=NPY2R PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22038 BP_3 19.95 0.37 2856 546684608 ERL94225.1 1776 2.1e-195 hypothetical protein D910_11506 [Dendroctonus ponderosae] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q640H3 747 1.8e-77 OTU domain-containing protein 5-B OS=Xenopus laevis GN=otud5-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.22039 BP_3 9.15 0.63 992 91093871 XP_967859.1 438 1.0e-40 PREDICTED: OTU domain-containing protein 5-A [Tribolium castaneum]>gi|270014527|gb|EFA10975.1| hypothetical protein TcasGA2_TC004141 [Tribolium castaneum] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q08BW0 151 8.2e-09 OTU domain-containing protein 5-A OS=Danio rerio GN=otud5a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.22040 BP_3 16.67 0.51 1868 91093871 XP_967859.1 1544 1.1e-168 PREDICTED: OTU domain-containing protein 5-A [Tribolium castaneum]>gi|270014527|gb|EFA10975.1| hypothetical protein TcasGA2_TC004141 [Tribolium castaneum] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q7ZX21 712 1.4e-73 OTU domain-containing protein 5-A OS=Xenopus laevis GN=otud5-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.22042 BP_3 2.00 0.94 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22044 BP_3 61.55 1.34 2507 91085445 XP_966423.1 602 2.5e-59 PREDICTED: peptidyl-tRNA hydrolase 2, mitochondrial [Tribolium castaneum]>gi|270009178|gb|EFA05626.1| hypothetical protein TcasGA2_TC015834 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 Q3ZBL5 274 1.1e-22 Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus GN=PTRH2 PE=2 SV=1 PF09243//PF01981//PF04434 Mitochondrial small ribosomal subunit Rsm22//Peptidyl-tRNA hydrolase PTH2//SWIM zinc finger GO:0006412 translation GO:0008168//GO:0008270//GO:0004045 methyltransferase activity//zinc ion binding//aminoacyl-tRNA hydrolase activity -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.22045 BP_3 121.00 15.22 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22046 BP_3 9.05 0.33 1599 642927976 XP_008195469.1 463 2.1e-43 PREDICTED: leptin receptor gene-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3Y064 291 7.7e-25 Leptin receptor gene-related protein OS=Takifugu rubripes GN=leprot PE=2 SV=1 PF07440 Caerin 1 protein -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.22047 BP_3 241.00 6.28 2141 91085745 XP_973735.1 1721 3.8e-189 PREDICTED: rabenosyn-5 [Tribolium castaneum]>gi|270010009|gb|EFA06457.1| hypothetical protein TcasGA2_TC009340 [Tribolium castaneum] -- -- -- -- -- K12481 ZFYVE20 rabenosyn-5 http://www.genome.jp/dbget-bin/www_bget?ko:K12481 Q80Y56 471 1.4e-45 Rabenosyn-5 OS=Mus musculus GN=Rbsn PE=2 SV=1 PF00096//PF06657//PF01363 Zinc finger, C2H2 type//Centrosome microtubule-binding domain of Cep57//FYVE zinc finger -- -- GO:0008017//GO:0008270//GO:0046872 microtubule binding//zinc ion binding//metal ion binding GO:0005622//GO:0045298 intracellular//tubulin complex KOG1842 FYVE finger-containing protein Cluster-8309.22048 BP_3 40.00 0.47 4384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22049 BP_3 449.17 5.21 4446 270005465 EFA01913.1 5364 0.0e+00 hypothetical protein TcasGA2_TC007523 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UGF1 3335 0.0e+00 WD repeat-containing protein 19 OS=Mus musculus GN=Wdr19 PE=1 SV=1 PF13181//PF06209//PF00637//PF13414 Tetratricopeptide repeat//Cofactor of BRCA1 (COBRA1)//Region in Clathrin and VPS//TPR repeat GO:0016192//GO:0006886//GO:0045892 vesicle-mediated transport//intracellular protein transport//negative regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG2247 WD40 repeat-containing protein Cluster-8309.2205 BP_3 1.00 3.39 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22051 BP_3 504.20 2.75 9142 642929789 XP_008195977.1 2705 1.3e-302 PREDICTED: oxysterol-binding protein-related protein 9 isoform X1 [Tribolium castaneum] 118150627 NM_001077805.1 77 6.54868e-29 Danio rerio oxysterol binding protein-like 9 (osbpl9), mRNA >gnl|BL_ORD_ID|3545007 Danio rerio oxysterol binding protein-like 9, mRNA (cDNA clone MGC:154069 IMAGE:8338829), complete cds -- -- -- -- Q0IJ05 1707 2.8e-188 Oxysterol-binding protein-related protein 9 OS=Xenopus tropicalis GN=osbpl9 PE=2 SV=1 PF05093//PF01421//PF10462//PF00413//PF01562 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//Reprolysin (M12B) family zinc metalloprotease//Peptidase M66//Matrixin//Reprolysin family propeptide GO:0016226//GO:0006508 iron-sulfur cluster assembly//proteolysis GO:0051536//GO:0008270//GO:0004222 iron-sulfur cluster binding//zinc ion binding//metalloendopeptidase activity GO:0031012//GO:0005737 extracellular matrix//cytoplasm KOG2210 Oxysterol-binding protein Cluster-8309.22058 BP_3 39.55 1.81 1345 91092208 XP_969730.1 1137 1.3e-121 PREDICTED: protein unc-50 homolog [Tribolium castaneum]>gi|270014482|gb|EFA10930.1| hypothetical protein TcasGA2_TC001757 [Tribolium castaneum] 602644740 XM_007428757.1 49 3.46364e-14 PREDICTED: Python bivittatus unc-50 homolog (C. elegans) (UNC50), transcript variant X5, mRNA -- -- -- -- Q9VHN5 860 6.8e-91 Protein unc-50 homolog OS=Drosophila melanogaster GN=CG9773 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3012 Uncharacterized conserved protein Cluster-8309.22062 BP_3 705.00 27.89 1510 642935173 XP_008199677.1 637 1.3e-63 PREDICTED: elongation of very long chain fatty acids protein 7 [Tribolium castaneum]>gi|270014194|gb|EFA10642.1| hypothetical protein TcasGA2_TC016279 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 A0JNC4 444 1.3e-42 Elongation of very long chain fatty acids protein 7 OS=Bos taurus GN=ELOVL7 PE=2 SV=1 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22063 BP_3 4.41 0.33 935 642936428 XP_008198430.1 990 9.7e-105 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462294748 APGK01052997.1 59 6.57889e-20 Dendroctonus ponderosae Seq01053007, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 320 2.0e-28 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22064 BP_3 3.36 0.61 557 642917126 XP_008191126.1 203 1.0e-13 PREDICTED: uncharacterized protein LOC659233 [Tribolium castaneum]>gi|270003488|gb|EEZ99935.1| hypothetical protein TcasGA2_TC002731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00658 Poly-adenylate binding protein, unique domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.22067 BP_3 566.61 7.53 3919 91092536 XP_967769.1 2382 1.6e-265 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 515 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1611 1.6e-177 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004674//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.22068 BP_3 48.84 6.74 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22069 BP_3 20.09 0.40 2703 642931541 XP_008196629.1 2039 6.4e-226 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 O75460 1229 2.2e-133 Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens GN=ERN1 PE=1 SV=2 PF06293//PF00069//PF07714//PF00804//PF06479 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Syntaxin//Ribonuclease 2-5A GO:0006468//GO:0006397//GO:0051252 protein phosphorylation//mRNA processing//regulation of RNA metabolic process GO:0004540//GO:0005524//GO:0004672//GO:0016772//GO:0016773 ribonuclease activity//ATP binding//protein kinase activity//transferase activity, transferring phosphorus-containing groups//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.22073 BP_3 36.61 1.11 1879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22077 BP_3 163.38 1.19 6928 102939 1510 3.6e-164 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1178 4.7e-127 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03310//PF04137//PF02966//PF00665//PF13683 Caulimovirus DNA-binding protein//Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//Mitosis protein DIM1//Integrase core domain//Integrase core domain GO:0015074//GO:0000398//GO:0055114 DNA integration//mRNA splicing, via spliceosome//oxidation-reduction process GO:0016671//GO:0003677//GO:0003756 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//DNA binding//protein disulfide isomerase activity GO:0005783//GO:0005681 endoplasmic reticulum//spliceosomal complex -- -- Cluster-8309.22080 BP_3 5.05 0.57 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22082 BP_3 999.00 658.57 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22083 BP_3 1675.80 38.04 2415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22084 BP_3 27.26 0.45 3191 91076316 XP_969753.1 1528 1.4e-166 PREDICTED: xylulose kinase [Tribolium castaneum]>gi|270002483|gb|EEZ98930.1| hypothetical protein TcasGA2_TC004550 [Tribolium castaneum] -- -- -- -- -- K00854 xylB, XYLB xylulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00854 O75191 1183 5.7e-128 Xylulose kinase OS=Homo sapiens GN=XYLB PE=1 SV=3 PF08114//PF00370//PF02782 ATPase proteolipid family//FGGY family of carbohydrate kinases, N-terminal domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0050790//GO:0005975 regulation of catalytic activity//carbohydrate metabolic process GO:0030234//GO:0016773 enzyme regulator activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG2531 Sugar (pentulose and hexulose) kinases Cluster-8309.22086 BP_3 46.79 1.00 2551 270011137 EFA07585.1 462 4.4e-43 ion transport peptide [Tribolium castaneum] 751224970 XM_011167549.1 89 3.86451e-36 PREDICTED: Solenopsis invicta ion transport peptide-like (LOC105200138), transcript variant X3, mRNA -- -- -- -- Q26492 414 6.7e-39 Ion transport peptide-like OS=Schistocerca gregaria PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22088 BP_3 776.70 25.05 1786 270011137 EFA07585.1 462 3.1e-43 ion transport peptide [Tribolium castaneum] 746837167 XM_011071011.1 88 9.67312e-36 PREDICTED: Acromyrmex echinatior ion transport peptide-like (LOC105155100), transcript variant X3, mRNA -- -- -- -- Q26492 414 4.7e-39 Ion transport peptide-like OS=Schistocerca gregaria PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22090 BP_3 5.00 1.71 432 642924686 XP_008194398.1 242 2.4e-18 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22091 BP_3 149.11 3.46 2371 642924686 XP_008194398.1 2209 1.1e-245 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD5 737 2.2e-76 Mitochondrial sodium/hydrogen exchanger 9B2 OS=Homo sapiens GN=SLC9B2 PE=1 SV=2 PF07086//PF00999 Jagunal, ER re-organisation during oogenesis//Sodium/hydrogen exchanger family GO:0006885//GO:0055085//GO:0006812//GO:0007029 regulation of pH//transmembrane transport//cation transport//endoplasmic reticulum organization GO:0015299 solute:proton antiporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG3826 Na+/H+ antiporter Cluster-8309.22093 BP_3 15.00 0.41 2062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22097 BP_3 51.49 5.92 711 91077456 XP_967801.1 688 7.7e-70 PREDICTED: sine oculis-binding protein homolog [Tribolium castaneum]>gi|270002754|gb|EEZ99201.1| sine oculis-binding protein [Tribolium castaneum] 768434667 XM_011560449.1 71 1.055e-26 PREDICTED: Plutella xylostella sine oculis-binding protein homolog (LOC105389350), partial mRNA -- -- -- -- Q0P5V2 260 1.4e-21 Sine oculis-binding protein homolog OS=Mus musculus GN=Sobp PE=2 SV=1 PF03884//PF06467//PF02069 Domain of unknown function (DUF329)//MYM-type Zinc finger with FCS sequence motif//Prokaryotic metallothionein -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.22098 BP_3 52.00 3.78 955 91077456 XP_967801.1 286 4.3e-23 PREDICTED: sine oculis-binding protein homolog [Tribolium castaneum]>gi|270002754|gb|EEZ99201.1| sine oculis-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.221 BP_3 28.00 1.79 1046 380447700 AFD54028.1 998 1.3e-105 GAPDH [Locusta migratoria] -- -- -- -- -- K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 P09317 965 3.5e-103 Glyceraldehyde-3-phosphate dehydrogenase OS=Ustilago maydis (strain 521 / FGSC 9021) GN=GAPD PE=3 SV=2 PF02800//PF00044 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.22104 BP_3 64.74 0.43 7522 751224154 XP_011165403.1 1304 3.0e-140 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07180 Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.22105 BP_3 70.43 0.42 8350 751224154 XP_011165403.1 1304 3.4e-140 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF07180 GPCR proteolysis site, GPS, motif//Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.22106 BP_3 55.61 2.55 1342 332375520 AEE62901.1 477 4.3e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7ZVE6 368 7.6e-34 KDEL motif-containing protein 1 OS=Danio rerio GN=kdelc1 PE=2 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.22107 BP_3 340.86 7.32 2537 91081993 XP_969039.1 1700 1.2e-186 PREDICTED: KDEL motif-containing protein 1 [Tribolium castaneum]>gi|270007375|gb|EFA03823.1| hypothetical protein TcasGA2_TC013938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UW63 1169 1.9e-126 KDEL motif-containing protein 1 OS=Homo sapiens GN=KDELC1 PE=1 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.22111 BP_3 1623.81 260.61 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22112 BP_3 5.01 0.63 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22114 BP_3 215.09 1.77 6145 642929679 XP_975498.3 2932 0.0e+00 PREDICTED: metastasis-associated protein MTA3 isoform X2 [Tribolium castaneum] 768415855 XM_011550194.1 183 5.22282e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1635 4.2e-180 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF00320//PF00096//PF01426 GATA zinc finger//Zinc finger, C2H2 type//BAH domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003682//GO:0003700//GO:0043565//GO:0008270 metal ion binding//chromatin binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0000785 transcription factor complex//chromatin KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.22116 BP_3 830.00 24.21 1944 642913803 XP_008201165.1 1411 3.1e-153 PREDICTED: alpha-2-macroglobulin receptor-associated protein [Tribolium castaneum]>gi|270002092|gb|EEZ98539.1| hypothetical protein TcasGA2_TC001043 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55302 405 5.7e-38 Alpha-2-macroglobulin receptor-associated protein OS=Mus musculus GN=Lrpap1 PE=1 SV=1 PF06401 Alpha-2-macroglobulin RAP, C-terminal domain GO:0007165 signal transduction GO:0008201//GO:0050750 heparin binding//low-density lipoprotein particle receptor binding GO:0005783 endoplasmic reticulum KOG3956 Alpha 2-macroglobulin receptor-associated protein Cluster-8309.22117 BP_3 610.65 15.08 2244 91078954 XP_974170.1 2607 7.3e-292 PREDICTED: negative elongation factor B [Tribolium castaneum]>gi|270004158|gb|EFA00606.1| hypothetical protein TcasGA2_TC003481 [Tribolium castaneum] -- -- -- -- -- K15180 COBRA1, NELFB negative elongation factor B http://www.genome.jp/dbget-bin/www_bget?ko:K15180 Q9Y113 2185 2.6e-244 Negative elongation factor B OS=Drosophila melanogaster GN=NELF-B PE=1 SV=1 PF06209//PF04997 Cofactor of BRCA1 (COBRA1)//RNA polymerase Rpb1, domain 1 GO:0006206//GO:0045892//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//negative regulation of transcription, DNA-templated//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.22118 BP_3 1.00 7.27 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22122 BP_3 19.82 0.37 2850 642910918 XP_008193464.1 1440 1.9e-156 PREDICTED: microphthalmia-associated transcription factor isoform X2 [Tribolium castaneum] 195469444 XM_002099612.1 83 9.35304e-33 Drosophila yakuba GE14571 (Dyak\GE14571), partial mRNA K09455 MITF microphthalmia-associated transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09455 O75030 326 1.2e-28 Microphthalmia-associated transcription factor OS=Homo sapiens GN=MITF PE=1 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG1318 Helix loop helix transcription factor EB Cluster-8309.22123 BP_3 366.18 9.39 2172 820805546 AKG92764.1 1085 2.2e-115 mitf [Leptinotarsa decemlineata] 820805545 KP147927.1 274 4.73429e-139 Leptinotarsa decemlineata mitf mRNA, complete cds K09455 MITF microphthalmia-associated transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09455 O75030 326 9.2e-29 Microphthalmia-associated transcription factor OS=Homo sapiens GN=MITF PE=1 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG1318 Helix loop helix transcription factor EB Cluster-8309.22125 BP_3 351.22 7.51 2547 642916580 XP_008191778.1 1808 3.7e-199 PREDICTED: heterogeneous nuclear ribonucleoprotein L [Tribolium castaneum] 642916579 XM_008193556.1 165 2.17889e-78 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein L (LOC657712), mRNA K13159 HNRNPL heterogeneous nuclear ribonucleoprotein L http://www.genome.jp/dbget-bin/www_bget?ko:K13159 P14866 442 3.8e-42 Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens GN=HNRNPL PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.22127 BP_3 94.16 1.01 4779 270013169 EFA09617.1 2675 2.0e-299 hypothetical protein TcasGA2_TC011738 [Tribolium castaneum] 195495540 XM_002095275.1 180 1.8866e-86 Drosophila yakuba GE19764 (Dyak\GE19764), partial mRNA K08819 CDK12_13 cyclin-dependent kinase 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K08819 Q9VP22 1822 6.8e-202 Cyclin-dependent kinase 12 OS=Drosophila melanogaster GN=Cdk12 PE=1 SV=1 PF07714//PF00876//PF04505//PF00069//PF08272 Protein tyrosine kinase//Innexin//Interferon-induced transmembrane protein//Protein kinase domain//Topoisomerase I zinc-ribbon-like GO:0009607//GO:0006265//GO:0006468 response to biotic stimulus//DNA topological change//protein phosphorylation GO:0003918//GO:0004672//GO:0005524//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//protein kinase activity//ATP binding//DNA binding GO:0005694//GO:0005921//GO:0016021 chromosome//gap junction//integral component of membrane KOG0600 Cdc2-related protein kinase Cluster-8309.2213 BP_3 38.24 1.64 1417 861649849 KMQ97012.1 643 2.5e-64 Cuticlin-1 [Lasius niger] 817183960 XM_012423831.1 174 1.19029e-83 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22130 BP_3 13.72 0.53 1542 642910948 XP_008193477.1 306 3.3e-25 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 P23687 195 1.0e-13 Prolyl endopeptidase OS=Sus scrofa GN=PREP PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2237 Predicted serine protease Cluster-8309.22132 BP_3 243.08 2.22 5567 646717479 KDR20323.1 3208 0.0e+00 Adenylate cyclase type 2 [Zootermopsis nevadensis] 769847817 XM_011636959.1 159 1.03816e-74 PREDICTED: Pogonomyrmex barbatus adenylate cyclase type 2 (LOC105425936), transcript variant X4, mRNA K08042 ADCY2 adenylate cyclase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08042 Q08462 1833 4.2e-203 Adenylate cyclase type 2 OS=Homo sapiens GN=ADCY2 PE=1 SV=5 PF07701//PF06327//PF00211 Heme NO binding associated//Domain of Unknown Function (DUF1053)//Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190//GO:0006171//GO:0006144//GO:0006182//GO:0046039 intracellular signal transduction//cyclic nucleotide biosynthetic process//cAMP biosynthetic process//purine nucleobase metabolic process//cGMP biosynthetic process//GTP metabolic process GO:0004016//GO:0016849//GO:0004383 adenylate cyclase activity//phosphorus-oxygen lyase activity//guanylate cyclase activity GO:0005886 plasma membrane -- -- Cluster-8309.22133 BP_3 1355.29 14.21 4889 270004843 EFA01291.1 3974 0.0e+00 cubitus interruptus [Tribolium castaneum] 170028989 XM_001842325.1 250 2.35967e-125 Culex quinquefasciatus cubitus interruptus, mRNA K16799 CI transcriptional activator cubitus interruptus http://www.genome.jp/dbget-bin/www_bget?ko:K16799 P19538 1162 2.4e-125 Transcriptional activator cubitus interruptus OS=Drosophila melanogaster GN=ci PE=1 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.22135 BP_3 21.00 1.15 1175 528515089 XP_005161614.1 575 1.6e-56 PREDICTED: zinc finger MYM-type protein 1-like [Danio rerio] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07462 Merozoite surface protein 1 (MSP1) C-terminus GO:0009405 pathogenesis -- -- GO:0016020 membrane -- -- Cluster-8309.22138 BP_3 114.74 1.26 4680 642910357 XP_008200291.1 5736 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase Genghis Khan [Tribolium castaneum] 642910356 XM_008202069.1 1045 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 2058 2.9e-229 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF01291//PF08826//PF00130//PF00069//PF00433//PF07714 LIF / OSM family//DMPK coiled coil domain like//Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase domain//Protein kinase C terminal domain//Protein tyrosine kinase GO:0007165//GO:0016310//GO:0009069//GO:0006468//GO:0006955//GO:0035556 signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//immune response//intracellular signal transduction GO:0005524//GO:0005125//GO:0004672//GO:0004674 ATP binding//cytokine activity//protein kinase activity//protein serine/threonine kinase activity GO:0005576 extracellular region KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.22140 BP_3 82.55 1.92 2359 642928571 XP_008199962.1 982 2.1e-103 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q7ZV22 906 5.5e-96 S-methyl-5'-thioadenosine phosphorylase OS=Danio rerio GN=mtap PE=2 SV=2 PF01048//PF09242 Phosphorylase superfamily//Flavocytochrome c sulphide dehydrogenase, flavin-binding GO:0009116//GO:0055114 nucleoside metabolic process//oxidation-reduction process GO:0003824//GO:0050660//GO:0016491 catalytic activity//flavin adenine dinucleotide binding//oxidoreductase activity -- -- KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.22143 BP_3 34.33 0.99 1957 332376416 AEE63348.1 742 1.2e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 343 8.8e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.22144 BP_3 6.68 0.36 1190 478254618 ENN74861.1 390 4.6e-35 hypothetical protein YQE_08631, partial [Dendroctonus ponderosae] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 -- -- -- -- PF07043//PF00230 Protein of unknown function (DUF1328)//Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020//GO:0005886 membrane//plasma membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.22146 BP_3 260.62 3.27 4139 642924140 XP_008194024.1 5579 0.0e+00 PREDICTED: neural-cadherin isoform X8 [Tribolium castaneum] 642924139 XM_008195802.1 1163 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X8, mRNA -- -- -- -- O15943 4793 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF00028//PF00868//PF03222 Cadherin domain//Transglutaminase family//Tryptophan/tyrosine permease family GO:0018149//GO:0007156//GO:0003333 peptide cross-linking//homophilic cell adhesion via plasma membrane adhesion molecules//amino acid transmembrane transport GO:0005509 calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.22149 BP_3 676.00 15.15 2442 546684295 ERL94000.1 1321 1.1e-142 hypothetical protein D910_11285 [Dendroctonus ponderosae] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V771 829 4.9e-87 Probable cytochrome P450 6a23 OS=Drosophila melanogaster GN=Cyp6a23 PE=2 SV=2 PF01924//PF00067 Hydrogenase formation hypA family//Cytochrome P450 GO:0055114 oxidation-reduction process GO:0046872//GO:0005506//GO:0020037//GO:0016705 metal ion binding//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.22150 BP_3 4.06 0.48 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22151 BP_3 27.32 1.18 1404 642923755 XP_008193870.1 975 8.0e-103 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0044763//GO:0050794 single-organism cellular process//regulation of cellular process -- -- -- -- -- -- Cluster-8309.22157 BP_3 19.11 0.92 1298 642913141 XP_008201410.1 706 1.1e-71 PREDICTED: C-5 sterol desaturase erg31-like [Tribolium castaneum] -- -- -- -- -- K00227 SC5DL, ERG3 delta7-sterol 5-desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K00227 -- -- -- -- PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- -- -- Cluster-8309.22159 BP_3 570.89 7.46 3980 642911874 XP_008199002.1 3056 0.0e+00 PREDICTED: WASH complex subunit 7 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 1906 1.0e-211 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3578 Uncharacterized conserved protein Cluster-8309.2216 BP_3 61.15 1.92 1824 642916061 XP_008190876.1 761 6.8e-78 PREDICTED: probable G-protein coupled receptor 21 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0V1P1 163 6.1e-10 Melanocortin receptor 4 OS=Danio rerio GN=mc4r PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22161 BP_3 573.89 5.83 5035 642911874 XP_008199002.1 3172 0.0e+00 PREDICTED: WASH complex subunit 7 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 1913 2.0e-212 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3578 Uncharacterized conserved protein Cluster-8309.22162 BP_3 888.44 103.87 704 270007760 EFA04208.1 192 2.5e-12 hypothetical protein TcasGA2_TC014457, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PH91 152 4.4e-09 Single-pass membrane and coiled-coil domain-containing protein 4 homolog OS=Anopheles gambiae GN=AGAP003534 PE=3 SV=3 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22163 BP_3 10.99 0.32 1956 642927014 XP_001810799.2 847 7.7e-88 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBA6 232 6.6e-18 Peroxisomal leader peptide-processing protease OS=Mus musculus GN=Tysnd1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.22164 BP_3 307.81 1.71 8984 642922229 XP_008193071.1 1543 7.0e-168 PREDICTED: thiamine transporter 2-like [Tribolium castaneum]>gi|270007226|gb|EFA03674.1| hypothetical protein TcasGA2_TC013776 [Tribolium castaneum] 642922228 XM_008194849.1 161 1.2978e-75 PREDICTED: Tribolium castaneum thiamine transporter 2-like (LOC661148), mRNA K14610 SLC19A2_3, THTR solute carrier family 19 (thiamine transporter), member 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14610 Q22931 693 1.1e-70 Folate-like transporter 3 OS=Caenorhabditis elegans GN=folt-3 PE=3 SV=3 PF01292//PF01770//PF13145//PF01384//PF00033//PF00639 Prokaryotic cytochrome b561//Reduced folate carrier//PPIC-type PPIASE domain//Phosphate transporter family//Cytochrome b/b6/petB//PPIC-type PPIASE domain GO:0022904//GO:0006817//GO:0006810//GO:0006118 respiratory electron transport chain//phosphate ion transport//transport//obsolete electron transport GO:0005542//GO:0016853//GO:0005315//GO:0009055//GO:0008518 folic acid binding//isomerase activity//inorganic phosphate transmembrane transporter activity//electron carrier activity//reduced folate carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3810 Micronutrient transporters (folate transporter family) Cluster-8309.22165 BP_3 26.50 0.35 3944 642937108 XP_008198694.1 2356 1.6e-262 PREDICTED: zinc finger and BTB domain-containing protein 49-like [Tribolium castaneum] 642937107 XM_008200472.1 160 2.03948e-75 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 49-like (LOC660399), mRNA -- -- -- -- Q05481 333 2.6e-29 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF05191//PF00651//PF01529//PF13912//PF13465//PF00096 Adenylate kinase, active site lid//BTB/POZ domain//DHHC palmitoyltransferase//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872//GO:0005515//GO:0008270 adenylate kinase activity//metal ion binding//protein binding//zinc ion binding -- -- -- -- Cluster-8309.22166 BP_3 32.50 0.37 4499 537136524 ERE66571.1 267 3.2e-20 zinc finger protein [Cricetulus griseus] 642937107 XM_008200472.1 160 2.32912e-75 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 49-like (LOC660399), mRNA -- -- -- -- Q14590 249 1.6e-19 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF01428//PF00651//PF02892//PF13912//PF06689//PF13465//PF00096 AN1-like Zinc finger//BTB/POZ domain//BED zinc finger//C2H2-type zinc finger//ClpX C4-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0003677//GO:0046983//GO:0005515//GO:0046872 zinc ion binding//DNA binding//protein dimerization activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.22167 BP_3 4.02 0.49 685 66524947 XP_624787.1 141 2.0e-06 PREDICTED: V-type proton ATPase subunit e 2-like [Apis mellifera] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.22168 BP_3 5.65 0.47 873 642931814 XP_008196744.1 595 5.8e-59 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q9VG82 369 3.8e-34 Probable cytochrome P450 9f2 OS=Drosophila melanogaster GN=Cyp9f2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.2217 BP_3 95.91 6.15 1043 91080175 XP_970509.1 366 2.5e-32 PREDICTED: organic solute transporter alpha-like protein [Tribolium castaneum]>gi|270005672|gb|EFA02120.1| hypothetical protein TcasGA2_TC007767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22171 BP_3 107.20 1.10 4988 270004612 EFA01060.1 532 6.6e-51 hypothetical protein TcasGA2_TC003978 [Tribolium castaneum] -- -- -- -- -- K19403 MCPH1 microcephalin http://www.genome.jp/dbget-bin/www_bget?ko:K19403 P61590 205 2.3e-14 Microcephalin OS=Colobus guereza GN=MCPH1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22173 BP_3 30.79 0.94 1871 478262792 ENN81309.1 291 2.2e-23 hypothetical protein YQE_02277, partial [Dendroctonus ponderosae] -- -- -- -- -- K19403 MCPH1 microcephalin http://www.genome.jp/dbget-bin/www_bget?ko:K19403 Q7TT79 134 1.4e-06 Microcephalin OS=Mus musculus GN=Mcph1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22176 BP_3 58.29 0.69 4378 546674526 ERL85886.1 4701 0.0e+00 hypothetical protein D910_03301 [Dendroctonus ponderosae] -- -- -- -- -- K14312 NUP155, NUP170, NUP157 nuclear pore complex protein Nup155 http://www.genome.jp/dbget-bin/www_bget?ko:K14312 Q99P88 2301 1.8e-257 Nuclear pore complex protein Nup155 OS=Mus musculus GN=Nup155 PE=1 SV=1 PF05184//PF06433//PF04454 Saposin-like type B, region 1//Methylamine dehydrogenase heavy chain (MADH)//Encapsulating protein for peroxidase GO:0042742//GO:0015947//GO:0006629//GO:0055114 defense response to bacterium//methane metabolic process//lipid metabolic process//oxidation-reduction process GO:0030058//GO:0008233 amine dehydrogenase activity//peptidase activity GO:0042597 periplasmic space KOG1900 Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170) Cluster-8309.22178 BP_3 36.70 1.12 1877 478252210 ENN72638.1 1453 4.0e-158 hypothetical protein YQE_10736, partial [Dendroctonus ponderosae] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 Q9VPH2 968 2.8e-103 DNA primase large subunit OS=Drosophila melanogaster GN=DNApol-alpha60 PE=1 SV=2 PF04104//PF00542 Eukaryotic and archaeal DNA primase, large subunit//Ribosomal protein L7/L12 C-terminal domain GO:0006351//GO:0006412//GO:0006269//GO:0042254 transcription, DNA-templated//translation//DNA replication, synthesis of RNA primer//ribosome biogenesis GO:0003896//GO:0003735 DNA primase activity//structural constituent of ribosome GO:0005657//GO:0005840//GO:0005730 replication fork//ribosome//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.22182 BP_3 20.00 0.96 1297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05104 Ribosome receptor lysine/proline rich region GO:0015031 protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.22183 BP_3 407.55 11.05 2069 91081013 XP_975219.1 1786 1.1e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 1.3e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.22186 BP_3 23.82 1.15 1293 478252777 ENN73170.1 209 4.9e-14 hypothetical protein YQE_10225, partial [Dendroctonus ponderosae] 642918204 XM_008193188.1 274 2.78696e-139 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22187 BP_3 18.18 0.91 1253 478252777 ENN73170.1 199 6.8e-13 hypothetical protein YQE_10225, partial [Dendroctonus ponderosae] 642918204 XM_008193188.1 274 2.69835e-139 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22189 BP_3 5.60 1.12 533 642918203 XP_008191409.1 560 4.0e-55 PREDICTED: zinc finger homeobox protein 4 isoform X2 [Tribolium castaneum] 642918204 XM_008193188.1 134 7.40045e-62 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.22190 BP_3 186.94 0.99 9398 642918201 XP_008191408.1 10448 0.0e+00 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918206 XM_008193189.1 795 0 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X4, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 Q15911 1905 3.2e-211 Zinc finger homeobox protein 3 OS=Homo sapiens GN=ZFHX3 PE=1 SV=2 PF00096//PF00046//PF04988//PF13912//PF01435//PF05920//PF13411 Zinc finger, C2H2 type//Homeobox domain//A-kinase anchoring protein 95 (AKAP95)//C2H2-type zinc finger//Peptidase family M48//Homeobox KN domain//MerR HTH family regulatory protein GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0046872//GO:0004222//GO:0003677 metal ion binding//metalloendopeptidase activity//DNA binding GO:0005634 nucleus KOG1146 Homeobox protein Cluster-8309.22197 BP_3 857.42 16.44 2805 91088529 XP_972184.1 2981 0.0e+00 PREDICTED: general vesicular transport factor p115 isoform X1 [Tribolium castaneum]>gi|270012234|gb|EFA08682.1| hypothetical protein TcasGA2_TC006352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41541 1790 2.1e-198 General vesicular transport factor p115 OS=Bos taurus GN=USO1 PE=1 SV=1 PF06009//PF04977//PF04111//PF05531//PF04869//PF13851//PF00170//PF04871//PF01496//PF10473//PF17078//PF02601 Laminin Domain II//Septum formation initiator//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein//Uso1 / p115 like vesicle tethering protein, head region//Growth-arrest specific micro-tubule binding//bZIP transcription factor//Uso1 / p115 like vesicle tethering protein, C terminal region//V-type ATPase 116kDa subunit family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SWI5-dependent HO expression protein 3//Exonuclease VII, large subunit GO:0006308//GO:0007155//GO:0048309//GO:0048280//GO:0015991//GO:0048870//GO:0051028//GO:0015031//GO:0015992//GO:0007049//GO:0006355//GO:0006886//GO:0006914 DNA catabolic process//cell adhesion//endoplasmic reticulum inheritance//vesicle fusion with Golgi apparatus//ATP hydrolysis coupled proton transport//cell motility//mRNA transport//protein transport//proton transport//cell cycle//regulation of transcription, DNA-templated//intracellular protein transport//autophagy GO:0042803//GO:0008855//GO:0003700//GO:0008565//GO:0015078//GO:0043565//GO:0045502//GO:0008134 protein homodimerization activity//exodeoxyribonuclease VII activity//transcription factor activity, sequence-specific DNA binding//protein transporter activity//hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//dynein binding//transcription factor binding GO:0033179//GO:0016020//GO:0000139//GO:0005667//GO:0030286//GO:0005737//GO:0009318//GO:0031514//GO:0019028 proton-transporting V-type ATPase, V0 domain//membrane//Golgi membrane//transcription factor complex//dynein complex//cytoplasm//exodeoxyribonuclease VII complex//motile cilium//viral capsid KOG0946 ER-Golgi vesicle-tethering protein p115 Cluster-8309.22198 BP_3 11678.95 205.35 3033 546671902 ERL84010.1 1764 5.6e-194 hypothetical protein D910_01329 [Dendroctonus ponderosae] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 1133 3.4e-122 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF00884//PF01676//PF01663//PF00245//PF01035 Sulfatase//Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase//Alkaline phosphatase//6-O-methylguanine DNA methyltransferase, DNA binding domain GO:0008152//GO:0006281 metabolic process//DNA repair GO:0008484//GO:0003824//GO:0046872//GO:0016791 sulfuric ester hydrolase activity//catalytic activity//metal ion binding//phosphatase activity -- -- -- -- Cluster-8309.2220 BP_3 3.00 0.78 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22201 BP_3 570.28 1.68 16677 765150019 XP_011485511.1 427 3.3e-38 PREDICTED: ring-infected erythrocyte surface antigen-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- P25386 202 1.7e-13 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22202 BP_3 145.88 1.45 5134 91083631 XP_970382.1 3673 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 2.0422e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2881 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF00205//PF03188//PF02826//PF01752//PF00005//PF02233//PF02456//PF00107//PF07074//PF00236 Thiamine pyrophosphate enzyme, central domain//Eukaryotic cytochrome b561//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Collagenase//ABC transporter//NAD(P) transhydrogenase beta subunit//Adenovirus IVa2 protein//Zinc-binding dehydrogenase//Translocon-associated protein, gamma subunit (TRAP-gamma)//Glycoprotein hormone GO:0006508//GO:0007165//GO:0006613//GO:0019083//GO:0046497//GO:0015992//GO:0006769//GO:0055114 proteolysis//signal transduction//cotranslational protein targeting to membrane//viral transcription//nicotinate nucleotide metabolic process//proton transport//nicotinamide metabolic process//oxidation-reduction process GO:0050661//GO:0005179//GO:0051287//GO:0000287//GO:0030976//GO:0005524//GO:0008750//GO:0008270//GO:0016887//GO:0004252 NADP binding//hormone activity//NAD binding//magnesium ion binding//thiamine pyrophosphate binding//ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//zinc ion binding//ATPase activity//serine-type endopeptidase activity GO:0030176//GO:0005784//GO:0005576//GO:0016021 integral component of endoplasmic reticulum membrane//Sec61 translocon complex//extracellular region//integral component of membrane -- -- Cluster-8309.22203 BP_3 4492.00 223.38 1261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22205 BP_3 25.65 0.57 2455 546677720 ERL88511.1 1304 9.9e-141 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 2.26897e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 964 1.1e-102 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.22206 BP_3 24.60 0.54 2502 478252719 ENN73114.1 812 1.1e-83 hypothetical protein YQE_10255, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VU84 589 3.4e-59 Drebrin-like protein OS=Drosophila melanogaster GN=Abp1 PE=1 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG3655 Drebrins and related actin binding proteins Cluster-8309.22207 BP_3 846.09 25.09 1917 546673853 ERL85383.1 1190 1.3e-127 hypothetical protein D910_02803 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GM14 706 7.0e-73 Drebrin-like protein B OS=Xenopus laevis GN=dbnl-b PE=2 SV=1 PF00241//PF00957//PF14604//PF00018 Cofilin/tropomyosin-type actin-binding protein//Synaptobrevin//Variant SH3 domain//SH3 domain GO:0016192 vesicle-mediated transport GO:0003779//GO:0005515 actin binding//protein binding GO:0016021//GO:0005622 integral component of membrane//intracellular KOG3655 Drebrins and related actin binding proteins Cluster-8309.22209 BP_3 11.00 1.24 721 795049583 XP_011869597.1 414 4.6e-38 PREDICTED: poly(A) polymerase type 3 isoform X2 [Vollenhovia emeryi] -- -- -- -- -- K14376 PAP poly(A) polymerase http://www.genome.jp/dbget-bin/www_bget?ko:K14376 P25500 354 1.7e-32 Poly(A) polymerase alpha OS=Bos taurus GN=PAPOLA PE=1 SV=3 PF04928 Poly(A) polymerase central domain GO:0043631 RNA polyadenylation GO:0004652 polynucleotide adenylyltransferase activity -- -- KOG2245 Poly(A) polymerase and related nucleotidyltransferases Cluster-8309.2221 BP_3 25.00 1.49 1103 594191368 AHL84105.1 953 2.2e-100 F0-ATP synthase b-chain [Litopenaeus vannamei] 67083944 DQ066270.1 55 1.30615e-17 Ixodes scapularis isolate is-all-clu620 putative ATP synthase-like protein mRNA, complete cds K02127 ATPeF0B, ATP5F1, ATP4 F-type H+-transporting ATPase subunit b http://www.genome.jp/dbget-bin/www_bget?ko:K02127 Q94516 655 3.3e-67 ATP synthase subunit b, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-b PE=2 SV=2 PF00610//PF05405 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015986//GO:0035556//GO:0015992 ATP synthesis coupled proton transport//intracellular signal transduction//proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG3976 Mitochondrial F1F0-ATP synthase, subunit b/ATP4 Cluster-8309.22212 BP_3 46.97 0.56 4321 91095023 XP_970355.1 619 4.7e-61 PREDICTED: inhibin beta chain [Tribolium castaneum]>gi|270015436|gb|EFA11884.1| dawdle [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 O61643 219 4.7e-16 Inhibin beta chain OS=Drosophila melanogaster GN=Actbeta PE=2 SV=2 PF00688//PF00019 TGF-beta propeptide//Transforming growth factor beta like domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0005576 extracellular region -- -- Cluster-8309.22213 BP_3 81.89 5.27 1041 91095023 XP_970355.1 843 1.2e-87 PREDICTED: inhibin beta chain [Tribolium castaneum]>gi|270015436|gb|EFA11884.1| dawdle [Tribolium castaneum] -- -- -- -- -- K04667 INHB inhibin, beta http://www.genome.jp/dbget-bin/www_bget?ko:K04667 O61643 277 2.1e-23 Inhibin beta chain OS=Drosophila melanogaster GN=Actbeta PE=2 SV=2 PF00019 Transforming growth factor beta like domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0005576 extracellular region KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.22214 BP_3 42.00 8.56 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22217 BP_3 25.97 0.81 1836 270008020 EFA04468.1 1274 2.2e-137 hypothetical protein TcasGA2_TC014772 [Tribolium castaneum] 195493568 XM_002094438.1 148 4.40533e-69 Drosophila yakuba GE20183 (Dyak\GE20183), partial mRNA -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22218 BP_3 35.00 1.75 1256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22219 BP_3 14.61 0.57 1537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667//PF04277 Phage shock protein B//Oxaloacetate decarboxylase, gamma chain GO:0009271//GO:0006525//GO:0006560//GO:0006090//GO:0071436//GO:0006814//GO:0006355 phage shock//arginine metabolic process//proline metabolic process//pyruvate metabolic process//sodium ion export//sodium ion transport//regulation of transcription, DNA-templated GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.2222 BP_3 33.00 2.75 870 642924714 XP_008194410.1 547 2.1e-53 PREDICTED: transcription factor glial cells missing isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22220 BP_3 18.41 3.31 560 642911647 XP_008200686.1 807 9.6e-84 PREDICTED: synapse-associated protein of 47 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 494 7.8e-49 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.22221 BP_3 133.29 14.43 737 642911647 XP_008200686.1 897 4.6e-94 PREDICTED: synapse-associated protein of 47 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 494 1.0e-48 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.22222 BP_3 9.81 0.33 1720 642930262 XP_971408.3 598 5.1e-59 PREDICTED: transmembrane protein 192 [Tribolium castaneum]>gi|270009437|gb|EFA05885.1| hypothetical protein TcasGA2_TC008697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NYE7 199 3.9e-14 Transmembrane protein 192 OS=Danio rerio GN=tmem192 PE=2 SV=1 PF04736 Eclosion hormone GO:0007218//GO:0018990 neuropeptide signaling pathway//ecdysis, chitin-based cuticle GO:0008255 ecdysis-triggering hormone activity -- -- -- -- Cluster-8309.22224 BP_3 28.00 1.62 1126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22225 BP_3 2.00 0.55 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22226 BP_3 9.44 0.36 1542 91081511 XP_974643.1 958 8.2e-101 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 P70280 704 9.6e-73 Vesicle-associated membrane protein 7 OS=Mus musculus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.22227 BP_3 34.46 1.38 1495 91081511 XP_974643.1 958 8.0e-101 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 P70280 704 9.3e-73 Vesicle-associated membrane protein 7 OS=Mus musculus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.2223 BP_3 55.00 3.15 1132 642924714 XP_008194410.1 1332 2.6e-144 PREDICTED: transcription factor glial cells missing isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27403 788 1.3e-82 Transcription factor glial cells missing OS=Drosophila melanogaster GN=gcm PE=1 SV=2 PF03615 GCM motif protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.22231 BP_3 605.32 9.18 3469 642928365 XP_008192713.1 1314 9.7e-142 PREDICTED: uncharacterized protein LOC103312832 isoform X1 [Tribolium castaneum]>gi|270010785|gb|EFA07233.1| hypothetical protein TcasGA2_TC010590 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRJ8 423 8.3e-40 Protein Asterix OS=Drosophila melanogaster GN=CG10674 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3462 Predicted membrane protein Cluster-8309.22232 BP_3 95.62 1.64 3108 642935439 XP_008198009.1 2401 7.8e-268 PREDICTED: uncharacterized protein LOC100141521 [Tribolium castaneum] 642935438 XM_008199787.1 314 3.95237e-161 PREDICTED: Tribolium castaneum uncharacterized LOC100141521 (LOC100141521), mRNA K11791 DCAF15 DDB1- and CUL4-associated factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K11791 Q3SZD5 195 2.0e-13 DDB1- and CUL4-associated factor 15 OS=Bos taurus GN=DCAF15 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22234 BP_3 168.17 2.92 3063 91091862 XP_968876.1 2084 4.4e-231 PREDICTED: AP-3 complex subunit mu-1 [Tribolium castaneum]>gi|270000812|gb|EEZ97259.1| hypothetical protein TcasGA2_TC011059 [Tribolium castaneum] 665801097 XM_008550322.1 231 5.36902e-115 PREDICTED: Microplitis demolitor AP-3 complex subunit mu-1 (LOC103571962), mRNA K12398 AP3M AP-3 complex subunit mu http://www.genome.jp/dbget-bin/www_bget?ko:K12398 Q9Y2T2 1623 5.2e-179 AP-3 complex subunit mu-1 OS=Homo sapiens GN=AP3M1 PE=1 SV=1 PF06046 Exocyst complex component Sec6 GO:0016192//GO:0006886//GO:0006887 vesicle-mediated transport//intracellular protein transport//exocytosis -- -- GO:0030131//GO:0000145 clathrin adaptor complex//exocyst KOG0937 Adaptor complexes medium subunit family Cluster-8309.22235 BP_3 176.83 3.06 3078 91091862 XP_968876.1 2084 4.4e-231 PREDICTED: AP-3 complex subunit mu-1 [Tribolium castaneum]>gi|270000812|gb|EEZ97259.1| hypothetical protein TcasGA2_TC011059 [Tribolium castaneum] 665801097 XM_008550322.1 231 5.39562e-115 PREDICTED: Microplitis demolitor AP-3 complex subunit mu-1 (LOC103571962), mRNA K12398 AP3M AP-3 complex subunit mu http://www.genome.jp/dbget-bin/www_bget?ko:K12398 Q9Y2T2 1623 5.2e-179 AP-3 complex subunit mu-1 OS=Homo sapiens GN=AP3M1 PE=1 SV=1 PF06046 Exocyst complex component Sec6 GO:0006886//GO:0016192//GO:0006887 intracellular protein transport//vesicle-mediated transport//exocytosis -- -- GO:0030131//GO:0000145 clathrin adaptor complex//exocyst KOG0937 Adaptor complexes medium subunit family Cluster-8309.22236 BP_3 618.07 11.04 2990 755879427 XP_005185085.2 2139 1.8e-237 PREDICTED: pre-mRNA-splicing factor CWC22 homolog [Musca domestica] -- -- -- -- -- K13100 CWC22 pre-mRNA-splicing factor CWC22 http://www.genome.jp/dbget-bin/www_bget?ko:K13100 Q9VJ87 2106 5.0e-235 Pre-mRNA-splicing factor CWC22 homolog OS=Drosophila melanogaster GN=ncm PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2140 Uncharacterized conserved protein Cluster-8309.22238 BP_3 30.93 0.34 4698 755879427 XP_005185085.2 2139 2.8e-237 PREDICTED: pre-mRNA-splicing factor CWC22 homolog [Musca domestica] -- -- -- -- -- K13100 CWC22 pre-mRNA-splicing factor CWC22 http://www.genome.jp/dbget-bin/www_bget?ko:K13100 Q9VJ87 2106 7.8e-235 Pre-mRNA-splicing factor CWC22 homolog OS=Drosophila melanogaster GN=ncm PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2140 Uncharacterized conserved protein Cluster-8309.22240 BP_3 5.59 0.95 574 270006808 EFA03256.1 185 1.3e-11 hypothetical protein TcasGA2_TC013190 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22241 BP_3 82.03 0.94 4478 270006808 EFA03256.1 1959 2.0e-216 hypothetical protein TcasGA2_TC013190 [Tribolium castaneum] 642924343 XM_008196035.1 453 0 PREDICTED: Tribolium castaneum voltage-gated potassium channel subunit beta-2 (LOC658668), mRNA K04883 KCNAB2 potassium voltage-gated channel Shaker-related subfamily A, beta member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04883 Q27955 988 3.3e-105 Voltage-gated potassium channel subunit beta-2 OS=Bos taurus GN=KCNAB2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1575 Voltage-gated shaker-like K+ channel, subunit beta/KCNAB Cluster-8309.22243 BP_3 18.00 0.49 2075 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22244 BP_3 1282.86 34.97 2060 189236562 XP_975592.2 838 9.0e-87 PREDICTED: programmed cell death protein 6 isoform X3 [Tribolium castaneum] 645007952 XM_008205559.1 80 3.13243e-31 PREDICTED: Nasonia vitripennis programmed cell death protein 6 (LOC100118174), transcript variant X2, mRNA -- -- -- -- P12815 605 3.9e-61 Programmed cell death protein 6 OS=Mus musculus GN=Pdcd6 PE=1 SV=2 PF13202//PF00036//PF10591//PF13833//PF13405//PF13499 EF hand//EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0037 Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.22245 BP_3 15.00 0.32 2562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22249 BP_3 17.94 4.45 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22250 BP_3 157.59 4.18 2110 642922975 XP_008200476.1 1247 3.5e-134 PREDICTED: growth hormone-regulated TBC protein 1 [Tribolium castaneum]>gi|270006542|gb|EFA02990.1| hypothetical protein TcasGA2_TC010409 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TC63 719 2.4e-74 Growth hormone-regulated TBC protein 1 OS=Homo sapiens GN=GRTP1 PE=1 SV=4 PF00947 Picornavirus core protein 2A GO:0006508//GO:0016032 proteolysis//viral process GO:0008233 peptidase activity GO:0005622 intracellular KOG2058 Ypt/Rab GTPase activating protein Cluster-8309.22251 BP_3 621.00 9.49 3447 478250321 ENN70818.1 2796 0.0e+00 hypothetical protein YQE_12483, partial [Dendroctonus ponderosae] 242015731 XM_002428456.1 231 6.05012e-115 Pediculus humanus corporis serine/threonine-protein kinase TBK1, putative, mRNA K05410 TBK1 TANK-binding kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05410 Q9WUN2 1152 2.4e-124 Serine/threonine-protein kinase TBK1 OS=Mus musculus GN=Tbk1 PE=1 SV=1 PF10104//PF07714//PF00069//PF05384 Di-sulfide bridge nucleocytoplasmic transport domain//Protein tyrosine kinase//Protein kinase domain//Sensor protein DegS GO:0006468//GO:0006611//GO:0006406//GO:0007165//GO:0006998 protein phosphorylation//protein export from nucleus//mRNA export from nucleus//signal transduction//nuclear envelope organization GO:0005524//GO:0004672//GO:0016301 ATP binding//protein kinase activity//kinase activity GO:0031965 nuclear membrane -- -- Cluster-8309.22252 BP_3 118.23 4.22 1642 642936089 XP_008198299.1 1531 3.1e-167 PREDICTED: transcription initiation factor TFIID subunit 2 [Tribolium castaneum]>gi|270013200|gb|EFA09648.1| hypothetical protein TcasGA2_TC011774 [Tribolium castaneum] -- -- -- -- -- K03128 TAF2 transcription initiation factor TFIID subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03128 Q24325 921 7.0e-98 Transcription initiation factor TFIID subunit 2 OS=Drosophila melanogaster GN=Taf2 PE=1 SV=2 PF02535//PF02985 ZIP Zinc transporter//HEAT repeat GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0005515//GO:0005488//GO:0008237//GO:0046873 protein binding//binding//metallopeptidase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG1932 TATA binding protein associated factor Cluster-8309.22253 BP_3 6.00 0.56 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22254 BP_3 347.05 2.85 6163 91077030 XP_967400.1 1924 3.2e-212 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1115 8.4e-120 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF07714//PF05028//PF03604//PF01029//PF06293//PF00069 Protein tyrosine kinase//Poly (ADP-ribose) glycohydrolase (PARG)//DNA directed RNA polymerase, 7 kDa subunit//NusB family//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0005975//GO:0006206//GO:0006355//GO:0006144//GO:0006468//GO:0006351 carbohydrate metabolic process//pyrimidine nucleobase metabolic process//regulation of transcription, DNA-templated//purine nucleobase metabolic process//protein phosphorylation//transcription, DNA-templated GO:0004672//GO:0004649//GO:0016773//GO:0003677//GO:0003723//GO:0003899//GO:0005524 protein kinase activity//poly(ADP-ribose) glycohydrolase activity//phosphotransferase activity, alcohol group as acceptor//DNA binding//RNA binding//DNA-directed RNA polymerase activity//ATP binding GO:0005730//GO:0016020 nucleolus//membrane KOG3087 Serine/threonine protein kinase Cluster-8309.22256 BP_3 16.12 0.83 1230 3421457 AAC32224.1 1754 3.3e-193 cytoplasmic actin [Dreissena polymorpha] 558184753 XM_006128029.1 386 0 PREDICTED: Pelodiscus sinensis actin, cytoplasmic type 5-like (LOC102458214), mRNA K12315 ACTG2 actin, gamma-enteric smooth muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12315 P41340 1741 4.3e-193 Actin-3 OS=Limulus polyphemus PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.22257 BP_3 263.80 5.22 2727 642933143 XP_008197274.1 3582 0.0e+00 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] 759040950 XM_011330978.1 45 1.19022e-11 PREDICTED: Cerapachys biroi UPF0378 protein KIAA0100 (LOC105274669), transcript variant X2, mRNA -- -- -- -- Q5SYL3 1445 2.0e-158 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=2 SV=1 PF02601 Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG1910 Uncharacterized conserved protein Cluster-8309.22258 BP_3 12.92 0.72 1151 642933143 XP_008197274.1 1157 5.1e-124 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14667 550 5.1e-55 Protein KIAA0100 OS=Homo sapiens GN=KIAA0100 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1910 Uncharacterized conserved protein Cluster-8309.22259 BP_3 6.95 0.36 1233 91084999 XP_973197.1 540 1.9e-52 PREDICTED: TBC1 domain family member 10A [Tribolium castaneum]>gi|270009019|gb|EFA05467.1| hypothetical protein TcasGA2_TC015650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHL3 383 1.3e-35 TBC1 domain family member 10B OS=Mus musculus GN=Tbc1d10b PE=1 SV=2 PF07340 Cytomegalovirus IE1 protein GO:0050792 regulation of viral process -- -- GO:0042025//GO:0005622 host cell nucleus//intracellular KOG2221 PDZ-domain interacting protein EPI64, contains TBC domain Cluster-8309.2226 BP_3 29.00 2.45 862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22260 BP_3 23.62 0.39 3213 91086355 XP_974424.1 1157 1.4e-123 PREDICTED: transcription factor TFIIIB component B'' homolog [Tribolium castaneum]>gi|270010281|gb|EFA06729.1| hypothetical protein TcasGA2_TC009660 [Tribolium castaneum] -- -- -- -- -- K15198 BDP1, TFC5 transcription factor TFIIIB component B'' http://www.genome.jp/dbget-bin/www_bget?ko:K15198 Q571C7 315 2.6e-27 Transcription factor TFIIIB component B'' homolog OS=Mus musculus GN=Bdp1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2009 Transcription initiation factor TFIIIB, Bdp1 subunit Cluster-8309.22261 BP_3 3.00 0.97 441 136032 P06708.1 600 7.6e-60 RecName: Full=Troponin C, isotype gamma [Pontastacus leptodactylus] 239949530 FJ790219.1 198 1.60159e-97 Homarus americanus troponin C isoform 2a mRNA, complete cds K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P06708 600 3.1e-61 Troponin C, isotype gamma OS=Astacus leptodactylus PE=1 SV=1 PF13202//PF03664//PF00036//PF12763//PF02881//PF13499//PF13833//PF13405 EF hand//Glycosyl hydrolase family 62//EF hand//Cytoskeletal-regulatory complex EF hand//SRP54-type protein, helical bundle domain//EF-hand domain pair//EF-hand domain pair//EF-hand domain GO:0046373//GO:0006614//GO:0009117//GO:0005975 L-arabinose metabolic process//SRP-dependent cotranslational protein targeting to membrane//nucleotide metabolic process//carbohydrate metabolic process GO:0005515//GO:0046556//GO:0005525//GO:0005509 protein binding//alpha-L-arabinofuranosidase activity//GTP binding//calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.22262 BP_3 16.00 1.83 713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22264 BP_3 20.56 0.53 2176 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22266 BP_3 133.04 15.04 718 642930467 XP_008196414.1 664 4.7e-67 PREDICTED: exosome complex component RRP46 [Tribolium castaneum] -- -- -- -- -- K12590 RRP46, EXOSC5 exosome complex component RRP46 http://www.genome.jp/dbget-bin/www_bget?ko:K12590 Q9CRA8 416 1.1e-39 Exosome complex component RRP46 OS=Mus musculus GN=Exosc5 PE=1 SV=1 PF07827 KNTase C-terminal domain GO:0046677 response to antibiotic GO:0016779 nucleotidyltransferase activity -- -- KOG1069 Exosomal 3'-5' exoribonuclease complex, subunit Rrp46 Cluster-8309.22267 BP_3 123.00 3.55 1960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22268 BP_3 249.06 2.66 4805 546677102 ERL88003.1 1067 5.9e-113 hypothetical protein D910_05392 [Dendroctonus ponderosae] -- -- -- -- -- K16751 C2CD3 C2 domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16751 Q4AC94 264 3.1e-21 C2 domain-containing protein 3 OS=Homo sapiens GN=C2CD3 PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.2227 BP_3 8.62 0.43 1252 357627156 EHJ76937.1 1010 6.2e-107 putative tigger transposable element derived 6-like protein [Danaus plexippus] 462344324 APGK01035087.1 170 1.75397e-81 Dendroctonus ponderosae Seq01035097, whole genome shotgun sequence -- -- -- -- Q8IY51 715 4.1e-74 Tigger transposable element-derived protein 4 OS=Homo sapiens GN=TIGD4 PE=2 SV=2 PF03184//PF01527//PF04218 DDE superfamily endonuclease//Transposase//CENP-B N-terminal DNA-binding domain GO:0006313 transposition, DNA-mediated GO:0003676//GO:0003677//GO:0004803 nucleic acid binding//DNA binding//transposase activity -- -- KOG3105 DNA-binding centromere protein B (CENP-B) Cluster-8309.22270 BP_3 35.00 1.48 1434 546681403 ERL91500.1 1175 5.3e-126 hypothetical protein D910_08830 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N5C7 425 2.0e-40 DTW domain-containing protein 1 OS=Homo sapiens GN=DTWD1 PE=1 SV=1 PF06512 Sodium ion transport-associated GO:0006814 sodium ion transport GO:0005248 voltage-gated sodium channel activity GO:0001518 voltage-gated sodium channel complex KOG3795 Uncharacterized conserved protein Cluster-8309.22272 BP_3 19.40 5.18 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22273 BP_3 159.00 2.51 3350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22274 BP_3 83.31 1.88 2426 642926835 XP_008195033.1 896 2.0e-93 PREDICTED: cyclin-L1 [Tribolium castaneum]>gi|270009183|gb|EFA05631.1| hypothetical protein TcasGA2_TC015839 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UK58 555 2.9e-55 Cyclin-L1 OS=Homo sapiens GN=CCNL1 PE=1 SV=1 PF02984 Cyclin, C-terminal domain GO:0000079//GO:0006396//GO:0006355 regulation of cyclin-dependent protein serine/threonine kinase activity//RNA processing//regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0005634 nucleus KOG0835 Cyclin L Cluster-8309.22276 BP_3 44.00 4.41 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22277 BP_3 44.32 0.69 3380 270013048 EFA09496.1 1145 3.7e-122 hypothetical protein TcasGA2_TC010990 [Tribolium castaneum] 242004796 XM_002423218.1 218 9.9956e-108 Pediculus humanus corporis RAB 3 and, putative, mRNA K07883 RAB3C Ras-related protein Rab-3C http://www.genome.jp/dbget-bin/www_bget?ko:K07883 P25228 1074 2.6e-115 Ras-related protein Rab-3 OS=Drosophila melanogaster GN=Rab3 PE=1 SV=1 PF01926//PF08477//PF02421//PF06821//PF00025//PF04451//PF03193//PF04670//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//Serine hydrolase//ADP-ribosylation factor family//Large eukaryotic DNA virus major capsid protein//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit GO:0007165//GO:0007186//GO:0015684//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//ferrous iron transport//small GTPase mediated signal transduction GO:0016787//GO:0031683//GO:0015093//GO:0003924//GO:0005198//GO:0019001//GO:0004871//GO:0005525 hydrolase activity//G-protein beta/gamma-subunit complex binding//ferrous iron transmembrane transporter activity//GTPase activity//structural molecule activity//guanyl nucleotide binding//signal transducer activity//GTP binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.22278 BP_3 204.76 3.33 3258 642934172 XP_969292.2 1143 6.1e-122 PREDICTED: ras-related protein Rab-3 isoform X1 [Tribolium castaneum] 242004796 XM_002423218.1 218 9.63092e-108 Pediculus humanus corporis RAB 3 and, putative, mRNA K07883 RAB3C Ras-related protein Rab-3C http://www.genome.jp/dbget-bin/www_bget?ko:K07883 P25228 1074 2.5e-115 Ras-related protein Rab-3 OS=Drosophila melanogaster GN=Rab3 PE=1 SV=1 PF00503//PF04670//PF00071//PF03193//PF04451//PF02421//PF06821//PF00025//PF08477//PF01926 G-protein alpha subunit//Gtr1/RagA G protein conserved region//Ras family//Protein of unknown function, DUF258//Large eukaryotic DNA virus major capsid protein//Ferrous iron transport protein B//Serine hydrolase//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007165//GO:0007186//GO:0007264//GO:0015684 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0016787//GO:0031683//GO:0005198//GO:0003924//GO:0005525//GO:0019001//GO:0004871 ferrous iron transmembrane transporter activity//hydrolase activity//G-protein beta/gamma-subunit complex binding//structural molecule activity//GTPase activity//GTP binding//guanyl nucleotide binding//signal transducer activity GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.22280 BP_3 22.72 2.28 771 91088597 XP_973576.1 241 5.7e-18 PREDICTED: ketimine reductase mu-crystallin [Tribolium castaneum]>gi|270012255|gb|EFA08703.1| hypothetical protein TcasGA2_TC006374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54983 137 2.7e-07 Ketimine reductase mu-crystallin OS=Mus musculus GN=Crym PE=1 SV=1 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0055114//GO:0009396//GO:0046487 oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- -- -- Cluster-8309.22281 BP_3 218.58 2.89 3938 91088597 XP_973576.1 880 2.3e-91 PREDICTED: ketimine reductase mu-crystallin [Tribolium castaneum]>gi|270012255|gb|EFA08703.1| hypothetical protein TcasGA2_TC006374 [Tribolium castaneum] -- -- -- -- -- K18258 CRYM thiomorpholine-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18258 Q14894 431 1.1e-40 Ketimine reductase mu-crystallin OS=Homo sapiens GN=CRYM PE=1 SV=1 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0003824//GO:0004488 catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG3007 Mu-crystallin Cluster-8309.22284 BP_3 90.98 0.99 4731 642915287 XP_008190556.1 2852 0.0e+00 PREDICTED: protein SCAI [Tribolium castaneum] 642915286 XM_008192334.1 554 0 PREDICTED: Tribolium castaneum protein SCAI (LOC661833), mRNA -- -- -- -- Q8C8N2 1534 1.7e-168 Protein SCAI OS=Mus musculus GN=Scai PE=1 SV=2 PF12070 Protein of unknown function (DUF3550/UPF0682) GO:0006351 transcription, DNA-templated GO:0003714 transcription corepressor activity GO:0005667 transcription factor complex -- -- Cluster-8309.22285 BP_3 177.00 15.42 845 270015167 EFA11615.1 402 1.3e-36 hypothetical protein TcasGA2_TC030555, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62954 266 3.2e-22 Bladder cancer-associated protein OS=Bos taurus GN=BLCAP PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4489 Uncharacterized conserved protein BC10 (implicated in bladder cancer in humans) Cluster-8309.22286 BP_3 117.00 3.59 1862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22289 BP_3 232.69 3.75 3282 642932843 XP_974466.2 2087 2.1e-231 PREDICTED: ralBP1-associated Eps domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54916 383 3.4e-35 RalBP1-associated Eps domain-containing protein 1 OS=Mus musculus GN=Reps1 PE=1 SV=2 PF13202//PF12763//PF13405//PF00036//PF13499//PF08057 EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain//EF hand//EF-hand domain pair//Erythromycin resistance leader peptide GO:0046677 response to antibiotic GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1955 Ral-GTPase effector RALBP1 Cluster-8309.2229 BP_3 93.00 1.16 4172 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22290 BP_3 406.31 6.48 3314 642932843 XP_974466.2 2087 2.1e-231 PREDICTED: ralBP1-associated Eps domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54916 383 3.4e-35 RalBP1-associated Eps domain-containing protein 1 OS=Mus musculus GN=Reps1 PE=1 SV=2 PF12763//PF13202//PF08057//PF13499//PF13405//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//Erythromycin resistance leader peptide//EF-hand domain pair//EF-hand domain//EF hand GO:0046677 response to antibiotic GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1955 Ral-GTPase effector RALBP1 Cluster-8309.22291 BP_3 586.65 39.87 1001 642913226 XP_975254.2 542 9.2e-53 PREDICTED: protein CutA homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K03926 cutA periplasmic divalent cation tolerance protein http://www.genome.jp/dbget-bin/www_bget?ko:K03926 Q66KY3 393 7.2e-37 Protein CutA homolog OS=Xenopus laevis GN=cuta PE=2 SV=2 PF03091 CutA1 divalent ion tolerance protein GO:0010038 response to metal ion -- -- -- -- KOG3338 Divalent cation tolerance-related protein Cluster-8309.22292 BP_3 713.43 26.53 1588 642936600 XP_008198502.1 838 6.9e-87 PREDICTED: NECAP-like protein CG9132 [Tribolium castaneum]>gi|642936602|ref|XP_972648.2| PREDICTED: NECAP-like protein CG9132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXB0 698 4.9e-72 NECAP-like protein CG9132 OS=Drosophila melanogaster GN=CG9132 PE=2 SV=1 PF07933 Protein of unknown function (DUF1681) GO:0006897 endocytosis -- -- GO:0016020 membrane KOG2500 Uncharacterized conserved protein Cluster-8309.22293 BP_3 550.69 6.36 4462 642929396 XP_008195819.1 2811 0.0e+00 PREDICTED: neogenin isoform X3 [Tribolium castaneum] -- -- -- -- -- K06766 NEO1 neogenin http://www.genome.jp/dbget-bin/www_bget?ko:K06766 Q90610 1000 1.3e-106 Neogenin (Fragment) OS=Gallus gallus PE=2 SV=1 PF16656//PF00041//PF06583//PF08465//PF01108 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Neogenin C-terminus//Thymidine kinase from Herpesvirus C-terminal//Tissue factor GO:0006771//GO:0006206//GO:0006230//GO:0019497 riboflavin metabolic process//pyrimidine nucleobase metabolic process//TMP biosynthetic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005524//GO:0004797//GO:0005515 acid phosphatase activity//metal ion binding//ATP binding//thymidine kinase activity//protein binding GO:0016021 integral component of membrane KOG4221 Receptor mediating netrin-dependent axon guidance Cluster-8309.22299 BP_3 460.98 4.81 4908 91080109 XP_967250.1 2070 3.0e-229 PREDICTED: uncharacterized protein LOC655596 isoform X1 [Tribolium castaneum]>gi|270003190|gb|EEZ99637.1| hypothetical protein TcasGA2_TC002393 [Tribolium castaneum] -- -- -- -- -- K15559 RTT103 regulator of Ty1 transposition protein 103 http://www.genome.jp/dbget-bin/www_bget?ko:K15559 Q9CSU0 773 3.0e-80 Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Mus musculus GN=Rprd1b PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.2230 BP_3 45.00 1.36 1887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22300 BP_3 51.54 0.98 2828 134031970 NP_001076793.1 1522 6.0e-166 ecdysis triggering hormone receptor isoform B [Tribolium castaneum]>gi|126116544|gb|ABN79654.1| ecdysis triggering hormone receptor isoform B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O93603 382 3.8e-35 Thyrotropin-releasing hormone receptor OS=Gallus gallus GN=TRHR PE=2 SV=1 PF00001//PF07057//PF01278 7 transmembrane receptor (rhodopsin family)//DNA helicase TraI//Omptin family GO:0007165//GO:0000746//GO:0007186//GO:0006508 signal transduction//conjugation//G-protein coupled receptor signaling pathway//proteolysis GO:0004175//GO:0005524//GO:0003678//GO:0004930//GO:0003677//GO:0016818//GO:0004871 endopeptidase activity//ATP binding//DNA helicase activity//G-protein coupled receptor activity//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//signal transducer activity GO:0009279//GO:0016021//GO:0005657 cell outer membrane//integral component of membrane//replication fork KOG3656 FOG: 7 transmembrane receptor Cluster-8309.22303 BP_3 328.96 8.22 2220 642910216 XP_008198443.1 2268 1.5e-252 PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum]>gi|642910218|ref|XP_967637.2| PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum] 642910217 XM_962544.2 453 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC655987), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 P49803 1449 5.7e-159 Regulator of G-protein signaling 7 OS=Rattus norvegicus GN=Rgs7 PE=2 SV=2 PF00610//PF00631 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//GGL domain GO:0035556//GO:0007186//GO:0007165 intracellular signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex KOG3589 G protein signaling regulators Cluster-8309.2231 BP_3 6.00 0.31 1232 641678700 XP_008188260.1 533 1.3e-51 PREDICTED: uncharacterized protein LOC103310749 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01355 High potential iron-sulfur protein GO:0019646//GO:0006118 aerobic electron transport chain//obsolete electron transport GO:0009055 electron carrier activity -- -- -- -- Cluster-8309.22311 BP_3 1.00 0.62 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22313 BP_3 81.30 1.73 2553 91092388 XP_968476.1 2123 1.1e-235 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 1.0984e-21 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22314 BP_3 64.68 1.57 2283 91092388 XP_968476.1 1718 9.1e-189 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 9.80619e-22 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22315 BP_3 6.00 0.51 863 91079538 XP_970846.1 1156 5.0e-124 PREDICTED: uncharacterized protein LOC659449 [Tribolium castaneum]>gi|270003424|gb|EEZ99871.1| hypothetical protein TcasGA2_TC002653 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04144//PF11480 SCAMP family//Colicin-E5 Imm protein GO:0030153//GO:0015031 bacteriocin immunity//protein transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22316 BP_3 2.00 1.24 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22318 BP_3 473.73 11.31 2310 91092760 XP_973551.1 1792 2.4e-197 PREDICTED: protein BCL9 homolog [Tribolium castaneum]>gi|270014793|gb|EFA11241.1| hypothetical protein TcasGA2_TC010773 [Tribolium castaneum] 642911481 XM_968458.3 460 0 PREDICTED: Tribolium castaneum protein BCL9 homolog (LOC662357), mRNA -- -- -- -- Q961D9 243 4.1e-19 Protein BCL9 homolog OS=Drosophila melanogaster GN=lgs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22322 BP_3 27681.09 9025.64 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22323 BP_3 29.79 0.92 1856 270007275 EFA03723.1 344 1.6e-29 hypothetical protein TcasGA2_TC013828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 363 4.0e-33 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22324 BP_3 17.16 0.69 1499 642920651 XP_008192505.1 170 1.9e-09 PREDICTED: zinc finger protein 143-like [Tribolium castaneum]>gi|270005214|gb|EFA01662.1| hypothetical protein TcasGA2_TC007234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03547 Membrane transport protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22325 BP_3 2.00 41.70 225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22327 BP_3 5.99 0.97 588 270003816 EFA00264.1 229 1.1e-16 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V5M3 128 2.2e-06 Longitudinals lacking protein, isoforms N/O/W/X/Y OS=Drosophila melanogaster GN=lola PE=1 SV=3 PF16622//PF13912//PF00301//PF02892//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Rubredoxin//BED zinc finger//Zinc finger, C2H2 type -- -- GO:0005506//GO:0046872//GO:0003677 iron ion binding//metal ion binding//DNA binding -- -- -- -- Cluster-8309.22328 BP_3 32.41 0.64 2739 642919741 XP_970851.2 899 1.0e-93 PREDICTED: protein daughter of sevenless [Tribolium castaneum]>gi|270005903|gb|EFA02351.1| hypothetical protein TcasGA2_TC008021 [Tribolium castaneum] -- -- -- -- -- K09593 GAB1 GRB2-associated-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09593 Q9VZZ9 380 6.3e-35 Protein daughter of sevenless OS=Drosophila melanogaster GN=dos PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22330 BP_3 301.00 5.58 2892 557018159 XP_006009466.1 622 1.4e-61 PREDICTED: uncharacterized protein LOC102349681 isoform X1 [Latimeria chalumnae]>gi|557018161|ref|XP_006009467.1| PREDICTED: uncharacterized protein LOC102349681 isoform X2 [Latimeria chalumnae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.22331 BP_3 144.57 1.35 5456 642915644 XP_972006.3 2982 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.3e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.22337 BP_3 24.45 0.55 2423 297139749 NP_001171929.1 1672 2.1e-183 LMBR1 domain-containing protein 2 homolog [Tribolium castaneum]>gi|270013548|gb|EFA09996.1| hypothetical protein TcasGA2_TC012164 [Tribolium castaneum] 815824957 XM_012378416.1 68 1.73083e-24 PREDICTED: Linepithema humile LMBR1 domain-containing protein 2 homolog (LOC105678779), mRNA -- -- -- -- Q8MRQ4 1153 1.3e-124 LMBR1 domain-containing protein 2 homolog OS=Drosophila melanogaster GN=CG8135 PE=2 SV=2 PF14777 Cilia BBSome complex subunit 10 GO:0042384 cilium assembly -- -- GO:0016021//GO:0034464 integral component of membrane//BBSome KOG2296 Integral membrane protein Cluster-8309.22339 BP_3 14.47 0.62 1412 642937476 XP_008198854.1 311 7.9e-26 PREDICTED: protein tramtrack, beta isoform-like isoform X15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2234 BP_3 11.00 0.84 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22340 BP_3 132.00 5.74 1401 91091400 XP_973804.1 1140 5.9e-122 PREDICTED: THO complex subunit 6 [Tribolium castaneum]>gi|270013056|gb|EFA09504.1| hypothetical protein TcasGA2_TC011605 [Tribolium castaneum] -- -- -- -- -- K13175 THOC6 THO complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13175 Q5XJS5 496 1.1e-48 THO complex subunit 6 homolog OS=Danio rerio GN=thoc6 PE=2 SV=1 PF04670//PF16906//PF00400 Gtr1/RagA G protein conserved region//Ribosomal proteins L26 eukaryotic, L24P archaeal//WD domain, G-beta repeat GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005525//GO:0003735//GO:0005515 GTP binding//structural constituent of ribosome//protein binding GO:0005840//GO:0015934 ribosome//large ribosomal subunit -- -- Cluster-8309.22341 BP_3 865.00 42.66 1269 478260562 ENN80265.1 224 8.8e-16 hypothetical protein YQE_03259, partial [Dendroctonus ponderosae]>gi|546685302|gb|ERL94829.1| hypothetical protein D910_12102 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22343 BP_3 163.90 6.45 1516 478258343 ENN78462.1 831 4.3e-86 hypothetical protein YQE_05100, partial [Dendroctonus ponderosae] -- -- -- -- -- K01389 MME neprilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01389 Q18673 411 8.9e-39 Neprilysin-1 OS=Caenorhabditis elegans GN=nep-1 PE=1 SV=3 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.22344 BP_3 18.43 0.36 2774 546676000 ERL87095.1 759 1.8e-77 hypothetical protein D910_04495, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IYA7 180 1.0e-11 Homeobox protein Mohawk OS=Homo sapiens GN=MKX PE=2 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.22345 BP_3 72.59 1.13 3388 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.5e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22346 BP_3 19.77 0.37 2853 642912555 XP_008200909.1 728 7.1e-74 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X1 [Tribolium castaneum]>gi|270002604|gb|EEZ99051.1| hypothetical protein TcasGA2_TC004926 [Tribolium castaneum] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q58DH2 407 4.9e-38 Phosphatidylserine decarboxylase proenzyme OS=Bos taurus GN=PISD PE=2 SV=1 PF02666 Phosphatidylserine decarboxylase GO:0006563//GO:0006566//GO:0006544//GO:0008654//GO:0046486 L-serine metabolic process//threonine metabolic process//glycine metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.22348 BP_3 738.16 21.96 1912 91089427 XP_974449.1 1703 4.2e-187 PREDICTED: switch-associated protein 70 [Tribolium castaneum]>gi|270012554|gb|EFA09002.1| hypothetical protein TcasGA2_TC006709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F4B2 332 1.6e-29 Switch-associated protein 70 OS=Gallus gallus GN=SWAP70 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2235 BP_3 858.00 91.44 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.22351 BP_3 499.75 11.57 2373 270008433 EFA04881.1 210 6.9e-14 hypothetical protein TcasGA2_TC014942 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22356 BP_3 156.64 13.31 859 642928987 XP_008195646.1 730 1.3e-74 PREDICTED: WD repeat-containing protein 74 [Tribolium castaneum]>gi|270009716|gb|EFA06164.1| hypothetical protein TcasGA2_TC009011 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58D06 174 1.5e-11 WD repeat-containing protein 74 OS=Bos taurus GN=WDR74 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3881 Uncharacterized conserved protein Cluster-8309.22357 BP_3 540.04 11.28 2599 642937696 XP_008198905.1 2543 2.2e-284 PREDICTED: cysteine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270000778|gb|EEZ97225.1| hypothetical protein TcasGA2_TC011023 [Tribolium castaneum] 768412406 XM_011569978.1 130 6.36103e-59 PREDICTED: Plutella xylostella cysteine--tRNA ligase, cytoplasmic (LOC105397950), mRNA K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q7KN90 2088 5.3e-233 Cysteine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-cys PE=1 SV=1 PF13465//PF01322//PF09334//PF00133 Zinc-finger double domain//Cytochrome C'//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V) GO:0006118//GO:0006418 obsolete electron transport//tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0009055//GO:0020037//GO:0004812//GO:0005506//GO:0046872 ATP binding//nucleotide binding//electron carrier activity//heme binding//aminoacyl-tRNA ligase activity//iron ion binding//metal ion binding -- -- KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.22358 BP_3 21.09 0.43 2656 642937696 XP_008198905.1 2513 6.9e-281 PREDICTED: cysteine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270000778|gb|EEZ97225.1| hypothetical protein TcasGA2_TC011023 [Tribolium castaneum] 768412406 XM_011569978.1 130 6.50244e-59 PREDICTED: Plutella xylostella cysteine--tRNA ligase, cytoplasmic (LOC105397950), mRNA K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q7KN90 2063 4.3e-230 Cysteine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-cys PE=1 SV=1 PF00750//PF09334//PF00133//PF13465//PF02970 tRNA synthetases class I (R)//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Zinc-finger double domain//Tubulin binding cofactor A GO:0006560//GO:0006525//GO:0006418//GO:0007021//GO:0006420 proline metabolic process//arginine metabolic process//tRNA aminoacylation for protein translation//tubulin complex assembly//arginyl-tRNA aminoacylation GO:0004814//GO:0015631//GO:0005524//GO:0046872//GO:0004812//GO:0000166//GO:0051082 arginine-tRNA ligase activity//tubulin binding//ATP binding//metal ion binding//aminoacyl-tRNA ligase activity//nucleotide binding//unfolded protein binding GO:0045298 tubulin complex KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.22365 BP_3 9.00 0.58 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22366 BP_3 3.00 0.46 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22367 BP_3 2.00 1.54 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22369 BP_3 24.60 2.07 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22370 BP_3 165.40 20.27 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22372 BP_3 12.54 0.43 1698 332375596 AEE62939.1 305 4.7e-25 unknown [Dendroctonus ponderosae] 830186132 XM_004692871.2 69 3.35131e-25 PREDICTED: Condylura cristata vesicle-associated membrane protein 1 (synaptobrevin 1) (VAMP1), mRNA K13505 VAMP3 vesicle-associated membrane protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13505 O02495 241 5.1e-19 Synaptobrevin-1 OS=Caenorhabditis elegans GN=snb-1 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.22374 BP_3 1.00 0.70 356 270016078 EFA12526.1 298 6.4e-25 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 183 5.7e-13 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.22376 BP_3 47.99 1.63 1709 478266693 ENN82870.1 1309 1.8e-141 hypothetical protein YQE_00763, partial [Dendroctonus ponderosae]>gi|546684080|gb|ERL93799.1| hypothetical protein D910_11085 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TS68 778 2.8e-81 Putative methyltransferase NSUN6 OS=Mus musculus GN=Nsun6 PE=2 SV=2 PF01728//PF01472//PF01189 FtsJ-like methyltransferase//PUA domain//16S rRNA methyltransferase RsmF GO:0032259 methylation GO:0003723//GO:0008168 RNA binding//methyltransferase activity -- -- KOG1122 tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) Cluster-8309.22377 BP_3 1309.00 25.37 2779 91084311 XP_976363.1 301 2.3e-24 PREDICTED: uncharacterized protein LOC660880 [Tribolium castaneum]>gi|270008806|gb|EFA05254.1| hypothetical protein TcasGA2_TC015406 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05393 Human adenovirus early E3A glycoprotein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22380 BP_3 5.00 0.82 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22382 BP_3 11.45 0.40 1663 153792270 NP_001093280.1 350 2.8e-30 malate dehydrogenase [Bombyx mori]>gi|95103050|gb|ABF51466.1| malate dehydrogenase [Bombyx mori] -- -- -- -- -- K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P78715 165 3.3e-10 Malic enzyme, hydrogenosomal OS=Neocallimastix frontalis PE=1 SV=1 -- -- GO:0006108//GO:0044710//GO:0006099 malate metabolic process//single-organism metabolic process//tricarboxylic acid cycle GO:0016616//GO:0004470//GO:0000166 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//malic enzyme activity//nucleotide binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.22383 BP_3 1473.44 37.39 2191 546676350 ERL87377.1 1897 1.5e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.4e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.22384 BP_3 379.00 29.31 915 642923408 XP_974329.2 491 6.9e-47 PREDICTED: small nuclear ribonucleoprotein-associated protein B [Tribolium castaneum]>gi|270008314|gb|EFA04762.1| hypothetical protein TcasGA2_TC030631 [Tribolium castaneum] 831297156 XM_012824943.1 36 3.92675e-07 PREDICTED: Clupea harengus small nuclear ribonucleoprotein polypeptides B and B1 (snrpb), mRNA K11086 SNRPB, SMB small nuclear ribonucleoprotein B and B' http://www.genome.jp/dbget-bin/www_bget?ko:K11086 Q05856 371 2.3e-34 Small nuclear ribonucleoprotein-associated protein B OS=Drosophila melanogaster GN=SmB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3168 U1 snRNP component Cluster-8309.22386 BP_3 26.91 1.67 1068 642918245 XP_008191428.1 234 5.1e-17 PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum]>gi|642918247|ref|XP_008191429.1| PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4F753 159 1.0e-09 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF02230//PF00326 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.22387 BP_3 264.09 16.15 1080 642918245 XP_008191428.1 265 1.3e-20 PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum]>gi|642918247|ref|XP_008191429.1| PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4F753 185 1.0e-12 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22388 BP_3 13.99 1.46 755 546676804 ERL87750.1 568 6.7e-56 hypothetical protein D910_05139 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 B4F753 267 2.2e-22 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF01764//PF14993//PF07859//PF02230//PF00975 Lipase (class 3)//Neuropeptide S precursor protein//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Thioesterase domain GO:0008152//GO:0007218//GO:0006629//GO:0009058 metabolic process//neuropeptide signaling pathway//lipid metabolic process//biosynthetic process GO:0016788//GO:0016787 hydrolase activity, acting on ester bonds//hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.22389 BP_3 24.94 0.84 1723 642922402 XP_008193142.1 376 2.8e-33 PREDICTED: transmembrane protein 198-B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q498W5 185 1.6e-12 Transmembrane protein 198-B OS=Danio rerio GN=tmem198b PE=2 SV=1 PF09207 Yeast killer toxin GO:0009405//GO:0008219 pathogenesis//cell death -- -- GO:0005576 extracellular region -- -- Cluster-8309.2239 BP_3 14.00 0.77 1173 478250393 ENN70888.1 614 4.8e-61 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P12276 241 3.6e-19 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.22390 BP_3 205.26 0.83 12211 270013018 EFA09466.1 6357 0.0e+00 hypothetical protein TcasGA2_TC010960 [Tribolium castaneum] 667677299 AE014296.5 67 3.17159e-23 Drosophila melanogaster chromosome 3L K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8WXX0 4321 0.0e+00 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 PF05418//PF00580//PF01637//PF04851//PF00910//PF02601//PF01695//PF07728//PF00158//PF00004//PF00437//PF03028//PF07724 Apovitellenin I (Apo-VLDL-II)//UvrD/REP helicase N-terminal domain//Archaeal ATPase//Type III restriction enzyme, res subunit//RNA helicase//Exonuclease VII, large subunit//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Dynein heavy chain and region D6 of dynein motor//AAA domain (Cdc48 subfamily) GO:0006308//GO:0006629//GO:0007017//GO:0006355//GO:0006810//GO:0007018 DNA catabolic process//lipid metabolic process//microtubule-based process//regulation of transcription, DNA-templated//transport//microtubule-based movement GO:0003724//GO:0008855//GO:0004857//GO:0003777//GO:0003723//GO:0003677//GO:0016887//GO:0008134//GO:0005524//GO:0016787 RNA helicase activity//exodeoxyribonuclease VII activity//enzyme inhibitor activity//microtubule motor activity//RNA binding//DNA binding//ATPase activity//transcription factor binding//ATP binding//hydrolase activity GO:0005874//GO:0005667//GO:0030286//GO:0042627//GO:0009318 microtubule//transcription factor complex//dynein complex//chylomicron//exodeoxyribonuclease VII complex -- -- Cluster-8309.22392 BP_3 228.36 6.65 1947 91089625 XP_973443.1 740 2.0e-75 PREDICTED: tudor and KH domain-containing protein [Tribolium castaneum]>gi|270012611|gb|EFA09059.1| hypothetical protein TcasGA2_TC006774 [Tribolium castaneum] -- -- -- -- -- K18406 TDRKH, TDRD2 tudor domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18406 Q80VL1 302 5.0e-26 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF07650//PF13014//PF13184//PF00013 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.22396 BP_3 214.67 2.81 3978 642920232 XP_008192259.1 462 6.9e-43 PREDICTED: uncharacterized protein LOC103312697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09003 Bacteriophage lambda integrase, N-terminal domain GO:0015074 DNA integration GO:0003677//GO:0008907 DNA binding//integrase activity -- -- -- -- Cluster-8309.22398 BP_3 118.77 1.33 4582 270006670 EFA03118.1 666 1.8e-66 hypothetical protein TcasGA2_TC013028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205 WH2 motif -- -- GO:0003779 actin binding -- -- -- -- Cluster-8309.22399 BP_3 20.05 3.40 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22402 BP_3 155.89 3.24 2614 556993813 XP_006001025.1 197 2.4e-12 PREDICTED: zinc finger protein 729-like [Latimeria chalumnae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5T619 185 2.5e-12 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1 PF13465//PF00096//PF01155//PF07975//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TFIIH C1-like domain//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006281//GO:0006464 DNA repair//cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.22405 BP_3 431.87 7.08 3231 642924249 XP_966647.3 2025 3.2e-224 PREDICTED: palmitoyltransferase ZDHHC18 [Tribolium castaneum] -- -- -- -- -- K16675 ZDHHC9_14_18 palmitoyltransferase ZDHHC9/14/18 http://www.genome.jp/dbget-bin/www_bget?ko:K16675 Q8BQQ1 1169 2.4e-126 Probable palmitoyltransferase ZDHHC14 OS=Mus musculus GN=Zdhhc14 PE=2 SV=1 PF13520//PF03699//PF01529//PF02419 Amino acid permease//Uncharacterised protein family (UPF0182)//DHHC palmitoyltransferase//PsbL protein GO:0006865//GO:0015979//GO:0003333 amino acid transport//photosynthesis//amino acid transmembrane transport GO:0015171//GO:0008270 amino acid transmembrane transporter activity//zinc ion binding GO:0016021//GO:0009539//GO:0009523//GO:0016020 integral component of membrane//photosystem II reaction center//photosystem II//membrane KOG1311 DHHC-type Zn-finger proteins Cluster-8309.22407 BP_3 569.91 11.80 2620 330417873 NP_001193392.1 1663 2.5e-182 glutathione S-transferase C-terminal domain-containing protein [Tribolium castaneum]>gi|270010443|gb|EFA06891.1| hypothetical protein TcasGA2_TC009836 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29LT4 994 3.8e-106 Glutathione S-transferase C-terminal domain-containing protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA10313 PE=3 SV=1 PF05439//PF05206//PF02390//PF02527//PF05175//PF01135 Jumping translocation breakpoint protein (JTB)//Methyltransferase TRM13//Putative methyltransferase//rRNA small subunit methyltransferase G//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006464//GO:0046500//GO:0006396//GO:0008033//GO:0006400//GO:0000154//GO:0009451//GO:0006479//GO:0006364 cellular protein modification process//S-adenosylmethionine metabolic process//RNA processing//tRNA processing//tRNA modification//rRNA modification//RNA modification//protein methylation//rRNA processing GO:0008649//GO:0004719//GO:0008176//GO:0008168 rRNA methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm -- -- Cluster-8309.22408 BP_3 192.34 4.33 2432 330417873 NP_001193392.1 1663 2.3e-182 glutathione S-transferase C-terminal domain-containing protein [Tribolium castaneum]>gi|270010443|gb|EFA06891.1| hypothetical protein TcasGA2_TC009836 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29LT4 994 3.6e-106 Glutathione S-transferase C-terminal domain-containing protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA10313 PE=3 SV=1 PF05439//PF05206//PF02527//PF02390//PF05175//PF01135 Jumping translocation breakpoint protein (JTB)//Methyltransferase TRM13//rRNA small subunit methyltransferase G//Putative methyltransferase//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006364//GO:0009451//GO:0006479//GO:0046500//GO:0006396//GO:0008033//GO:0006400//GO:0000154//GO:0006464 rRNA processing//RNA modification//protein methylation//S-adenosylmethionine metabolic process//RNA processing//tRNA processing//tRNA modification//rRNA modification//cellular protein modification process GO:0004719//GO:0008176//GO:0008168//GO:0008649 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//rRNA methyltransferase activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.22410 BP_3 13.00 2.53 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22411 BP_3 31.52 0.71 2444 91079416 XP_967408.1 1380 1.5e-149 PREDICTED: microspherule protein 1 isoform X1 [Tribolium castaneum]>gi|270004380|gb|EFA00828.1| hypothetical protein TcasGA2_TC003716 [Tribolium castaneum] -- -- -- -- -- K11674 MCRS1, INO80Q microspherule protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11674 Q96EZ8 838 4.4e-88 Microspherule protein 1 OS=Homo sapiens GN=MCRS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2293 Daxx-interacting protein MSP58/p78, contains FHA domain Cluster-8309.22412 BP_3 12.00 2.90 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22413 BP_3 19.00 0.41 2523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22416 BP_3 15.00 0.45 1903 641657806 XP_008180482.1 161 2.6e-08 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22419 BP_3 3.00 1.11 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2242 BP_3 3.85 0.53 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22420 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22421 BP_3 58.12 2.66 1346 641656545 XP_008180002.1 252 5.3e-19 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 3 isoform X3 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q92626 180 4.8e-12 Peroxidasin homolog OS=Homo sapiens GN=PXDN PE=1 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22422 BP_3 3.00 1.55 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22423 BP_3 50.76 2.35 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22424 BP_3 10.26 0.50 1281 270002611 EEZ99058.1 460 3.8e-43 hypothetical protein TcasGA2_TC004933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22425 BP_3 18.15 2.05 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22426 BP_3 29.00 1.55 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22428 BP_3 91.49 3.31 1624 642935048 XP_008199920.1 1059 1.7e-112 PREDICTED: polymerase delta-interacting protein 3-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG81 182 3.4e-12 Polymerase delta-interacting protein 3 OS=Mus musculus GN=Poldip3 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.22430 BP_3 165.39 6.25 1567 642929649 XP_008195920.1 175 5.2e-10 PREDICTED: uncharacterized protein LOC664363 isoform X7 [Tribolium castaneum]>gi|270010570|gb|EFA07018.1| hypothetical protein TcasGA2_TC009989 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22431 BP_3 671.98 13.24 2738 642917250 XP_967285.3 1472 3.6e-160 PREDICTED: SPARC-related modular calcium-binding protein 2 isoform X2 [Tribolium castaneum] 642917249 XM_962192.3 115 1.46087e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA -- -- -- -- Q8BLY1 323 2.6e-28 SPARC-related modular calcium-binding protein 1 OS=Mus musculus GN=Smoc1 PE=2 SV=2 PF13405//PF00050//PF10591//PF00036//PF13499//PF07648//PF13202 EF-hand domain//Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain pair//Kazal-type serine protease inhibitor domain//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4578 Uncharacterized conserved protein, contains KAZAL and TY domains Cluster-8309.22432 BP_3 26.74 0.81 1892 642917248 XP_008199221.1 1001 1.0e-105 PREDICTED: SPARC-related modular calcium-binding protein 2 isoform X1 [Tribolium castaneum] 642917249 XM_962192.3 115 1.00433e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA -- -- -- -- Q8BLY1 323 1.8e-28 SPARC-related modular calcium-binding protein 1 OS=Mus musculus GN=Smoc1 PE=2 SV=2 PF13405//PF00036//PF10591//PF13499//PF13202 EF-hand domain//EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4578 Uncharacterized conserved protein, contains KAZAL and TY domains Cluster-8309.22434 BP_3 10.44 0.46 1391 91084273 XP_971218.1 209 5.3e-14 PREDICTED: ATP-binding cassette sub-family D member 2 [Tribolium castaneum]>gi|270008750|gb|EFA05198.1| hypothetical protein TcasGA2_TC015333 [Tribolium castaneum] -- -- -- -- -- K05675 ABCD1, ALD ATP-binding cassette, subfamily D (ALD), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05675 P48410 178 8.5e-12 ATP-binding cassette sub-family D member 1 OS=Mus musculus GN=Abcd1 PE=1 SV=1 -- -- GO:0006200//GO:0006810//GO:0055085 obsolete ATP catabolic process//transport//transmembrane transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016021 integral component of membrane KOG0060 Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis) Cluster-8309.22436 BP_3 3577.42 209.19 1116 150416593 ABF60889.2 204 1.6e-13 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.22437 BP_3 520.33 13.70 2123 642939750 XP_008195710.1 1352 2.3e-146 PREDICTED: protein FAM43A, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2R8 308 1.1e-26 Protein FAM43A OS=Homo sapiens GN=FAM43A PE=2 SV=2 PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4448 Uncharacterized conserved protein, contains phosphotyrosine interaction (PI) domain Cluster-8309.22438 BP_3 40.44 1.28 1813 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22439 BP_3 1768.05 76.69 1403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22442 BP_3 17.17 0.56 1768 642933608 XP_008197492.1 1967 9.4e-218 PREDICTED: stress-activated protein kinase JNK isoform X1 [Tribolium castaneum] 170029895 XM_001842775.1 532 0 Culex quinquefasciatus jnk, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1693 2.3e-187 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF03708//PF06293//PF00069//PF07714 Avian retrovirus envelope protein, gp85//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0019031//GO:0016020 viral envelope//membrane -- -- Cluster-8309.22443 BP_3 354.56 7.41 2599 189237609 XP_968824.2 1850 5.1e-204 PREDICTED: sodium/potassium/calcium exchanger 3-like isoform X1 [Tribolium castaneum] 347972526 XM_563948.4 154 2.89735e-72 Anopheles gambiae str. PEST AGAP010977-PA (AgaP_AGAP010977) mRNA, partial cds K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q49SH1 712 1.9e-73 Sodium/potassium/calcium exchanger 5 OS=Danio rerio GN=slc24a5 PE=2 SV=1 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.22444 BP_3 40.33 0.38 5413 642939012 XP_008197805.1 3065 0.0e+00 PREDICTED: exportin-4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0E2 1558 3.2e-171 Exportin-4 OS=Homo sapiens GN=XPO4 PE=1 SV=2 PF03810 Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0008536 Ran GTPase binding -- -- KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily) Cluster-8309.22445 BP_3 13.85 0.50 1633 91080393 XP_966637.1 1289 3.6e-139 PREDICTED: rab proteins geranylgeranyltransferase component A 1 [Tribolium castaneum]>gi|270005742|gb|EFA02190.1| hypothetical protein TcasGA2_TC007846 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXG2 710 2.0e-73 Rab proteins geranylgeranyltransferase component A 1 OS=Mus musculus GN=Chm PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4405 GDP dissociation inhibitor Cluster-8309.22447 BP_3 2711.49 15.38 8788 91093683 XP_970017.1 1672 7.5e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 2.4e-75 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01553//PF04136//PF00115//PF01395 Acyltransferase//Sec34-like family//Cytochrome C and Quinol oxidase polypeptide I//PBP/GOBP family GO:0006118//GO:0015992//GO:0055114//GO:0009060//GO:0006123//GO:0006886//GO:0008152 obsolete electron transport//proton transport//oxidation-reduction process//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//metabolic process GO:0005506//GO:0005549//GO:0009055//GO:0020037//GO:0004129//GO:0016746 iron ion binding//odorant binding//electron carrier activity//heme binding//cytochrome-c oxidase activity//transferase activity, transferring acyl groups GO:0005801//GO:0016021//GO:0016020//GO:0045277 cis-Golgi network//integral component of membrane//membrane//respiratory chain complex IV KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.22448 BP_3 191.10 1.05 9068 91093683 XP_970017.1 1672 7.8e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 2.4e-75 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01553//PF04136//PF00115//PF01395 Acyltransferase//Sec34-like family//Cytochrome C and Quinol oxidase polypeptide I//PBP/GOBP family GO:0008152//GO:0006123//GO:0009060//GO:0006886//GO:0006118//GO:0055114//GO:0015992 metabolic process//mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration//intracellular protein transport//obsolete electron transport//oxidation-reduction process//proton transport GO:0016746//GO:0009055//GO:0004129//GO:0020037//GO:0005549//GO:0005506 transferase activity, transferring acyl groups//electron carrier activity//cytochrome-c oxidase activity//heme binding//odorant binding//iron ion binding GO:0045277//GO:0016020//GO:0016021//GO:0005801 respiratory chain complex IV//membrane//integral component of membrane//cis-Golgi network KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.22449 BP_3 35.15 0.68 2796 642910948 XP_008193477.1 2947 0.0e+00 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 2067 1.6e-230 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF02897//PF00326 Prolyl oligopeptidase, N-terminal beta-propeller domain//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0070008//GO:0008236//GO:0004252 serine-type exopeptidase activity//serine-type peptidase activity//serine-type endopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.22450 BP_3 9.00 0.74 880 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22451 BP_3 4.09 0.43 752 270011645 EFA08093.1 166 2.7e-09 hypothetical protein TcasGA2_TC005697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22453 BP_3 9.29 2.56 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22456 BP_3 37.60 0.37 5210 270011645 EFA08093.1 1357 1.5e-146 hypothetical protein TcasGA2_TC005697 [Tribolium castaneum] -- -- -- -- -- K14442 DHX36, RHAU ATP-dependent RNA helicase DHX36 http://www.genome.jp/dbget-bin/www_bget?ko:K14442 Q8VHK9 1068 2.0e-114 ATP-dependent RNA helicase DHX36 OS=Mus musculus GN=Dhx36 PE=1 SV=2 PF00005//PF02562//PF01637//PF04851//PF00270//PF00910//PF00931//PF04408//PF05279//PF00158//PF00004//PF00437//PF00448 ABC transporter//PhoH-like protein//Archaeal ATPase//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//RNA helicase//NB-ARC domain//Helicase associated domain (HA2)//Aspartyl beta-hydroxylase N-terminal region//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain GO:0006614//GO:0006810//GO:0006355 SRP-dependent cotranslational protein targeting to membrane//transport//regulation of transcription, DNA-templated GO:0003677//GO:0003723//GO:0004386//GO:0043531//GO:0003676//GO:0005525//GO:0003724//GO:0016787//GO:0005524//GO:0008134//GO:0016887 DNA binding//RNA binding//helicase activity//ADP binding//nucleic acid binding//GTP binding//RNA helicase activity//hydrolase activity//ATP binding//transcription factor binding//ATPase activity GO:0005667//GO:0016020 transcription factor complex//membrane KOG0920 ATP-dependent RNA helicase A Cluster-8309.22457 BP_3 62.37 0.69 4641 270011645 EFA08093.1 206 3.9e-13 hypothetical protein TcasGA2_TC005697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0009522//GO:0009579//GO:0016021 photosystem I//thylakoid//integral component of membrane -- -- Cluster-8309.22458 BP_3 887.67 11.32 4070 642932116 XP_008196861.1 2518 2.8e-281 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- K14442 DHX36, RHAU ATP-dependent RNA helicase DHX36 http://www.genome.jp/dbget-bin/www_bget?ko:K14442 Q8VHK9 1875 4.1e-208 ATP-dependent RNA helicase DHX36 OS=Mus musculus GN=Dhx36 PE=1 SV=2 PF00005//PF04851//PF02562//PF01637//PF00270//PF00931//PF14532//PF00158//PF04408//PF00437//PF00448 ABC transporter//Type III restriction enzyme, res subunit//PhoH-like protein//Archaeal ATPase//DEAD/DEAH box helicase//NB-ARC domain//Sigma-54 interaction domain//Sigma-54 interaction domain//Helicase associated domain (HA2)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain GO:0006355//GO:0006810//GO:0006614 regulation of transcription, DNA-templated//transport//SRP-dependent cotranslational protein targeting to membrane GO:0016887//GO:0003676//GO:0005525//GO:0008134//GO:0043531//GO:0016787//GO:0003677//GO:0004386//GO:0005524 ATPase activity//nucleic acid binding//GTP binding//transcription factor binding//ADP binding//hydrolase activity//DNA binding//helicase activity//ATP binding GO:0005667 transcription factor complex KOG0920 ATP-dependent RNA helicase A Cluster-8309.22459 BP_3 97.55 1.29 3947 642932116 XP_008196861.1 206 3.3e-13 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0009579//GO:0009522//GO:0016021 thylakoid//photosystem I//integral component of membrane -- -- Cluster-8309.22460 BP_3 54.19 0.77 3689 642932116 XP_008196861.1 1494 1.4e-162 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- K14442 DHX36, RHAU ATP-dependent RNA helicase DHX36 http://www.genome.jp/dbget-bin/www_bget?ko:K14442 Q8VHK9 1096 8.0e-118 ATP-dependent RNA helicase DHX36 OS=Mus musculus GN=Dhx36 PE=1 SV=2 PF00005//PF02562//PF01637//PF04851//PF00270//PF00931//PF00910//PF04408//PF05279//PF00158//PF00004//PF00437//PF00448 ABC transporter//PhoH-like protein//Archaeal ATPase//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//NB-ARC domain//RNA helicase//Helicase associated domain (HA2)//Aspartyl beta-hydroxylase N-terminal region//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain GO:0006614//GO:0006810//GO:0006355 SRP-dependent cotranslational protein targeting to membrane//transport//regulation of transcription, DNA-templated GO:0016787//GO:0005524//GO:0008134//GO:0016887//GO:0003677//GO:0003723//GO:0004386//GO:0043531//GO:0003676//GO:0005525//GO:0003724 hydrolase activity//ATP binding//transcription factor binding//ATPase activity//DNA binding//RNA binding//helicase activity//ADP binding//nucleic acid binding//GTP binding//RNA helicase activity GO:0005667//GO:0016020 transcription factor complex//membrane KOG0920 ATP-dependent RNA helicase A Cluster-8309.22462 BP_3 35.57 0.47 3907 642932116 XP_008196861.1 1494 1.5e-162 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- K14442 DHX36, RHAU ATP-dependent RNA helicase DHX36 http://www.genome.jp/dbget-bin/www_bget?ko:K14442 Q8VHK9 1096 8.5e-118 ATP-dependent RNA helicase DHX36 OS=Mus musculus GN=Dhx36 PE=1 SV=2 PF00931//PF00910//PF00270//PF02562//PF01637//PF04851//PF00005//PF00448//PF00004//PF00437//PF04408//PF05279//PF00158 NB-ARC domain//RNA helicase//DEAD/DEAH box helicase//PhoH-like protein//Archaeal ATPase//Type III restriction enzyme, res subunit//ABC transporter//SRP54-type protein, GTPase domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Helicase associated domain (HA2)//Aspartyl beta-hydroxylase N-terminal region//Sigma-54 interaction domain GO:0006810//GO:0006614//GO:0006355 transport//SRP-dependent cotranslational protein targeting to membrane//regulation of transcription, DNA-templated GO:0008134//GO:0005524//GO:0016787//GO:0016887//GO:0043531//GO:0003723//GO:0004386//GO:0003677//GO:0003724//GO:0005525//GO:0003676 transcription factor binding//ATP binding//hydrolase activity//ATPase activity//ADP binding//RNA binding//helicase activity//DNA binding//RNA helicase activity//GTP binding//nucleic acid binding GO:0005667//GO:0016020 transcription factor complex//membrane KOG0920 ATP-dependent RNA helicase A Cluster-8309.22463 BP_3 148.30 1.63 4671 642932116 XP_008196861.1 206 3.9e-13 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0016021//GO:0009522//GO:0009579 integral component of membrane//photosystem I//thylakoid -- -- Cluster-8309.22464 BP_3 155.71 3.40 2502 158562474 ABW74143.1 482 2.1e-45 cuticular protein Ld-CP3 [Leptinotarsa decemlineata] 766935802 XM_011501981.1 36 1.09923e-06 PREDICTED: Ceratosolen solmsi marchali endocuticle structural glycoprotein SgAbd-8-like (LOC105364117), mRNA -- -- -- -- Q7M4F3 319 6.8e-28 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF08089//PF00379 Huwentoxin-II family//Insect cuticle protein GO:0009405 pathogenesis GO:0042302 structural constituent of cuticle GO:0005576 extracellular region -- -- Cluster-8309.22466 BP_3 2.00 0.83 406 780705867 XP_011703203.1 222 4.8e-16 PREDICTED: fatty acid synthase [Wasmannia auropunctata]>gi|780705871|ref|XP_011703204.1| PREDICTED: fatty acid synthase [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- P12785 143 2.8e-08 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22467 BP_3 1076.38 33.25 1852 642911995 XP_969577.2 780 4.3e-80 PREDICTED: translocon-associated protein subunit beta [Tribolium castaneum] -- -- -- -- -- K13250 SSR2 translocon-associated protein subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K13250 Q9CPW5 475 4.1e-46 Translocon-associated protein subunit beta OS=Mus musculus GN=Ssr2 PE=1 SV=1 PF06481//PF11857 COX Aromatic Rich Motif//Domain of unknown function (DUF3377) GO:0055114//GO:0022900//GO:0006118 oxidation-reduction process//electron transport chain//obsolete electron transport GO:0004222//GO:0008827 metalloendopeptidase activity//cytochrome o ubiquinol oxidase activity GO:0009319//GO:0016021 cytochrome o ubiquinol oxidase complex//integral component of membrane KOG3317 Translocon-associated complex TRAP, beta subunit Cluster-8309.22470 BP_3 20.00 9.37 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.22471 BP_3 3.00 16.09 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22473 BP_3 106.40 0.84 6390 642917129 XP_008191127.1 2575 1.1e-287 PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917131|ref|XP_008191128.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917133|ref|XP_008191129.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|270003487|gb|EEZ99934.1| hypothetical protein TcasGA2_TC002730 [Tribolium castaneum] 642917132 XM_008192907.1 839 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X3, mRNA -- -- -- -- Q6P9K8 396 2.1e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22475 BP_3 1.00 2.65 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22476 BP_3 1009.89 13.40 3924 642917135 XP_008191130.1 2261 1.7e-251 PREDICTED: caskin-1 isoform X2 [Tribolium castaneum]>gi|642917145|ref|XP_008191135.1| PREDICTED: caskin-1 isoform X2 [Tribolium castaneum] 642917136 XM_008192909.1 808 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X5, mRNA -- -- -- -- Q6P9K8 396 1.3e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22477 BP_3 565.70 7.28 4037 642917137 XP_008191131.1 2292 4.4e-255 PREDICTED: caskin-1 isoform X3 [Tribolium castaneum] 642917136 XM_008192909.1 810 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X5, mRNA -- -- -- -- Q6P9K8 396 1.3e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22478 BP_3 560.50 6.23 4631 642917129 XP_008191127.1 2575 7.8e-288 PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917131|ref|XP_008191128.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917133|ref|XP_008191129.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|270003487|gb|EEZ99934.1| hypothetical protein TcasGA2_TC002730 [Tribolium castaneum] 642917132 XM_008192907.1 839 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X3, mRNA -- -- -- -- Q6P9K8 396 1.5e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22481 BP_3 13.51 0.35 2174 642917135 XP_008191130.1 1299 3.3e-140 PREDICTED: caskin-1 isoform X2 [Tribolium castaneum]>gi|642917145|ref|XP_008191135.1| PREDICTED: caskin-1 isoform X2 [Tribolium castaneum] 642917136 XM_008192909.1 378 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X5, mRNA -- -- -- -- Q8VHK2 392 2.0e-36 Caskin-1 OS=Rattus norvegicus GN=Caskin1 PE=1 SV=1 PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22482 BP_3 1270.14 14.29 4576 642926401 XP_008191947.1 3150 0.0e+00 PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|642926403|ref|XP_008191948.1| PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|270009223|gb|EFA05671.1| hormone receptor in 39-like protein [Tribolium castaneum] 642926402 XM_008193726.1 635 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 beta (LOC658947), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 Q05192 1612 1.5e-177 Nuclear hormone receptor FTZ-F1 beta OS=Drosophila melanogaster GN=Hr39 PE=1 SV=3 PF03846//PF00104//PF00105 Cell division inhibitor SulA//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0009432//GO:0043401//GO:0051782//GO:0006355//GO:0007165 SOS response//steroid hormone mediated signaling pathway//negative regulation of cell division//regulation of transcription, DNA-templated//signal transduction GO:0043565//GO:0008270//GO:0046872//GO:0003700//GO:0003707 sequence-specific DNA binding//zinc ion binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//steroid hormone receptor activity GO:0005634//GO:0009276//GO:0005667 nucleus//Gram-negative-bacterium-type cell wall//transcription factor complex -- -- Cluster-8309.22484 BP_3 86.67 7.31 863 478249755 ENN70263.1 495 2.2e-47 hypothetical protein YQE_13046, partial [Dendroctonus ponderosae] -- -- -- -- -- K06695 PSMC3IP 26S proteasome regulatory subunit, ATPase 3, interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K06695 Q63ZL2 310 2.6e-27 Homologous-pairing protein 2 homolog OS=Xenopus laevis GN=psmc3ip PE=2 SV=1 PF08702//PF02601//PF10186//PF03965//PF06156 Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Vacuolar sorting 38 and autophagy-related subunit 14//Penicillinase repressor//Protein of unknown function (DUF972) GO:0051258//GO:0007165//GO:0006308//GO:0010508//GO:0045892//GO:0030168//GO:0006260 protein polymerization//signal transduction//DNA catabolic process//positive regulation of autophagy//negative regulation of transcription, DNA-templated//platelet activation//DNA replication GO:0008855//GO:0003677//GO:0030674//GO:0005102 exodeoxyribonuclease VII activity//DNA binding//protein binding, bridging//receptor binding GO:0005577//GO:0009318 fibrinogen complex//exodeoxyribonuclease VII complex KOG4603 TBP-1 interacting protein Cluster-8309.22485 BP_3 6.89 1.60 499 478256535 ENN76719.1 422 3.8e-39 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86V71 265 2.5e-22 Zinc finger protein 429 OS=Homo sapiens GN=ZNF429 PE=2 SV=2 PF02892//PF00412//PF13912//PF00130//PF13465//PF00096 BED zinc finger//LIM domain//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556 intracellular signal transduction GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.22487 BP_3 225.33 1.92 5947 642934790 XP_008197809.1 453 1.1e-41 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22488 BP_3 36.61 1.09 1915 642919246 XP_008191792.1 900 5.4e-94 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 523 1.2e-51 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22489 BP_3 478.18 8.77 2919 478262421 ENN81092.1 670 3.9e-67 hypothetical protein YQE_02460, partial [Dendroctonus ponderosae]>gi|546673642|gb|ERL85206.1| hypothetical protein D910_02627 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05261//PF05485 TraM protein, DNA-binding//THAP domain GO:0000746 conjugation GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.2249 BP_3 80.00 3.06 1552 -- -- -- -- -- 768311752 CP010980.1 1549 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- P79017 623 2.4e-63 Major allergen Asp f 2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=AFUA_4G09580 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22491 BP_3 90.29 0.52 8718 270017072 EFA13518.1 1980 1.4e-218 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1356 1.3e-147 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF00098 Integrase core domain//Zinc knuckle GO:0015074 DNA integration GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.22492 BP_3 2304.86 30.36 3951 91088785 XP_967679.1 5125 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 1A [Tribolium castaneum]>gi|270011628|gb|EFA08076.1| hypothetical protein TcasGA2_TC005672 [Tribolium castaneum] 700253021 KM397468.1 42 8.05629e-10 Dioscorea oppositifolia structural maintenance of chromosomes protein 1 mRNA, partial cds K06636 SMC1 structural maintenance of chromosome 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06636 Q9CU62 2985 0.0e+00 Structural maintenance of chromosomes protein 1A OS=Mus musculus GN=Smc1a PE=1 SV=4 PF06470//PF13304//PF02984//PF04513 SMC proteins Flexible Hinge Domain//AAA domain, putative AbiEii toxin, Type IV TA system//Cyclin, C-terminal domain//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0030261//GO:0007062//GO:0006310//GO:0006281//GO:0051276 chromosome condensation//sister chromatid cohesion//DNA recombination//DNA repair//chromosome organization GO:0005198//GO:0005515//GO:0005524 structural molecule activity//protein binding//ATP binding GO:0005694//GO:0019031//GO:0005634//GO:0019028 chromosome//viral envelope//nucleus//viral capsid KOG0018 Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin, subunit SMC1) Cluster-8309.22494 BP_3 1.00 1.05 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22495 BP_3 38.07 0.43 4560 91085249 XP_973267.1 1086 3.5e-115 PREDICTED: thioredoxin-related transmembrane protein 2 homolog [Tribolium castaneum]>gi|270009096|gb|EFA05544.1| hypothetical protein TcasGA2_TC015732 [Tribolium castaneum] 815899095 XM_012394754.1 156 3.95071e-73 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 3.2e-92 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00085//PF02144//PF00149//PF04139//PF04005 Thioredoxin//Repair protein Rad1/Rec1/Rad17//Calcineurin-like phosphoesterase//Rad9//Hus1-like protein GO:0000077//GO:0006281//GO:0045454 DNA damage checkpoint//DNA repair//cell redox homeostasis GO:0016787 hydrolase activity GO:0005634//GO:0030896 nucleus//checkpoint clamp complex KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.22496 BP_3 28.47 0.50 3063 642917749 XP_008191355.1 1984 1.7e-219 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N9H8 554 4.7e-55 Exonuclease mut-7 homolog OS=Homo sapiens GN=EXD3 PE=2 SV=3 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding -- -- KOG4373 Predicted 3'-5' exonuclease Cluster-8309.22497 BP_3 20.00 1.15 1130 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22502 BP_3 188.08 3.45 2920 642910499 XP_008200240.1 1303 1.5e-140 PREDICTED: G protein alpha i subunit [Tribolium castaneum]>gi|270014387|gb|EFA10835.1| hypothetical protein TcasGA2_TC001612 [Tribolium castaneum] 769853321 XM_011639851.1 168 5.37507e-80 PREDICTED: Pogonomyrmex barbatus guanine nucleotide-binding protein G(i) subunit alpha (LOC105427877), mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 P20353 1166 4.9e-126 G protein alpha i subunit OS=Drosophila melanogaster GN=Galphai PE=1 SV=2 PF00503//PF00025 G-protein alpha subunit//ADP-ribosylation factor family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0031683//GO:0004871//GO:0019001//GO:0003924 GTP binding//G-protein beta/gamma-subunit complex binding//signal transducer activity//guanyl nucleotide binding//GTPase activity -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.22503 BP_3 27.17 0.71 2130 91089077 XP_971296.1 436 3.8e-40 PREDICTED: density-regulated protein [Tribolium castaneum]>gi|270012410|gb|EFA08858.1| hypothetical protein TcasGA2_TC006559 [Tribolium castaneum] 389609388 AK401684.1 122 1.45535e-54 Papilio xuthus mRNA for similar to CG9099, complete cds, sequence id: Px-1124 -- -- -- -- Q9VX98 365 2.7e-33 Density-regulated protein homolog OS=Drosophila melanogaster GN=DENR PE=1 SV=3 PF01253 Translation initiation factor SUI1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG3239 Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.22504 BP_3 33.00 0.53 3313 91090776 XP_969654.1 4098 0.0e+00 PREDICTED: glutamate [NMDA] receptor subunit 1 [Tribolium castaneum]>gi|270013267|gb|EFA09715.1| hypothetical protein TcasGA2_TC011848 [Tribolium castaneum] 516282937 KC814695.1 597 0 Apis cerana cerana NMDA receptor 1 (Nmdar1) mRNA, complete cds K05208 GRIN1 glutamate receptor ionotropic, NMDA 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05208 B3LZ39 3202 0.0e+00 Glutamate [NMDA] receptor subunit 1 OS=Drosophila ananassae GN=Nmdar1 PE=3 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0035235//GO:0006811//GO:0007165//GO:0007268 ionotropic glutamate receptor signaling pathway//ion transport//signal transduction//synaptic transmission GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0030054//GO:0016020//GO:0045211//GO:0016021//GO:0005886 cell junction//membrane//postsynaptic membrane//integral component of membrane//plasma membrane KOG4440 NMDA selective glutamate-gated ion channel receptor subunit GRIN1 Cluster-8309.22505 BP_3 24.10 0.41 3133 827539582 XP_012552934.1 177 6.1e-10 PREDICTED: transcription factor Ken 1-like [Bombyx mori] -- -- -- -- -- -- -- -- -- Q7KQZ4 158 4.0e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22507 BP_3 34.70 0.63 2965 642933271 XP_008197352.1 668 6.7e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933270 XM_008199130.1 229 6.72041e-114 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X1, mRNA -- -- -- -- Q65Z95 602 1.2e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.22508 BP_3 187.15 3.86 2630 642933271 XP_008197352.1 671 2.7e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933270 XM_008199130.1 229 5.95593e-114 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X1, mRNA -- -- -- -- Q65Z95 602 1.1e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.2251 BP_3 4.00 1.15 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22510 BP_3 9.27 0.38 1459 270013964 EFA10412.1 786 6.8e-81 hypothetical protein TcasGA2_TC012652 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22511 BP_3 544.48 14.38 2117 478260638 ENN80341.1 1309 2.2e-141 hypothetical protein YQE_03333, partial [Dendroctonus ponderosae]>gi|546685233|gb|ERL94760.1| hypothetical protein D910_12034 [Dendroctonus ponderosae] -- -- -- -- -- K16723 STG M-phase inducer phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16723 P20483 654 8.3e-67 M-phase inducer phosphatase OS=Drosophila melanogaster GN=stg PE=1 SV=2 PF16093//PF00598 Proteasome assembly chaperone 4//Influenza Matrix protein (M1) GO:0043248 proteasome assembly GO:0005198//GO:0003723 structural molecule activity//RNA binding -- -- KOG3772 M-phase inducer phosphatase Cluster-8309.22514 BP_3 32.58 9.31 460 91078888 XP_973143.1 409 1.1e-37 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 O55173 294 9.9e-26 3-phosphoinositide-dependent protein kinase 1 OS=Rattus norvegicus GN=Pdpk1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.22515 BP_3 7.71 0.38 1260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22519 BP_3 2096.77 46.52 2464 546671832 ERL83974.1 934 8.0e-98 hypothetical protein D910_01284 [Dendroctonus ponderosae]>gi|546675381|gb|ERL86589.1| hypothetical protein D910_03996 [Dendroctonus ponderosae]>gi|546677899|gb|ERL88647.1| hypothetical protein D910_06031 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q62283 386 1.1e-35 Tetraspanin-7 OS=Mus musculus GN=Tspan7 PE=2 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22521 BP_3 1.00 0.33 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22527 BP_3 12.00 1.02 858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2253 BP_3 2.00 0.42 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22533 BP_3 40.49 0.84 2612 642926997 XP_008195097.1 1745 7.7e-192 PREDICTED: mitotic spindle assembly checkpoint protein MAD1 [Tribolium castaneum]>gi|270010044|gb|EFA06492.1| hypothetical protein TcasGA2_TC009389 [Tribolium castaneum] -- -- -- -- -- K06638 MAD1L mitotic spindle assembly checkpoint protein MAD1 http://www.genome.jp/dbget-bin/www_bget?ko:K06638 Q9WTX8 468 3.8e-45 Mitotic spindle assembly checkpoint protein MAD1 OS=Mus musculus GN=Mad1l1 PE=2 SV=1 PF07926//PF04799//PF09177//PF03739//PF10473//PF04513//PF00038//PF05557//PF08287//PF04632//PF04977//PF07851 TPR/MLP1/MLP2-like protein//fzo-like conserved region//Syntaxin 6, N-terminal//Predicted permease YjgP/YjgQ family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Baculovirus polyhedron envelope protein, PEP, C terminus//Intermediate filament protein//Mitotic checkpoint protein//Spc19//Fusaric acid resistance protein family//Septum formation initiator//TMPIT-like protein GO:0007049//GO:0008608//GO:0006606//GO:0006810//GO:0008053//GO:0007094//GO:0048193 cell cycle//attachment of spindle microtubules to kinetochore//protein import into nucleus//transport//mitochondrial fusion//mitotic spindle assembly checkpoint//Golgi vesicle transport GO:0005198//GO:0008134//GO:0003924//GO:0045502//GO:0042803 structural molecule activity//transcription factor binding//GTPase activity//dynein binding//protein homodimerization activity GO:0005876//GO:0042729//GO:0005882//GO:0019028//GO:0016021//GO:0005741//GO:0016020//GO:0019031//GO:0005667//GO:0005886//GO:0030286 spindle microtubule//DASH complex//intermediate filament//viral capsid//integral component of membrane//mitochondrial outer membrane//membrane//viral envelope//transcription factor complex//plasma membrane//dynein complex KOG4593 Mitotic checkpoint protein MAD1 Cluster-8309.22536 BP_3 16.00 2.74 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2254 BP_3 89.63 2.91 1777 642925037 XP_008194147.1 246 3.4e-18 PREDICTED: uncharacterized protein LOC103313208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22540 BP_3 5.07 0.32 1047 646707351 KDR14157.1 298 1.9e-24 Importin subunit alpha-7 [Zootermopsis nevadensis] 665802087 XM_008550863.1 50 7.4492e-15 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15042 KPNA1 importin subunit alpha-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15042 P52294 230 6.0e-18 Importin subunit alpha-5 OS=Homo sapiens GN=KPNA1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0166 Karyopherin (importin) alpha Cluster-8309.22541 BP_3 8.00 0.96 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22542 BP_3 250.64 2.32 5492 270007679 EFA04127.1 2228 1.6e-247 hypothetical protein TcasGA2_TC014370 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH60 563 7.6e-56 Golgi-associated PDZ and coiled-coil motif-containing protein OS=Mus musculus GN=Gopc PE=1 SV=1 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22543 BP_3 23.00 1.55 1008 91085237 XP_972967.1 1029 3.1e-109 PREDICTED: NAD-dependent protein deacetylase Sirt4 [Tribolium castaneum] -- -- -- -- -- K11414 SIRT4, SIR2L4 NAD-dependent deacetylase sirtuin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11414 Q8IRR5 860 5.1e-91 NAD-dependent protein deacylase Sirt4 OS=Drosophila melanogaster GN=Sirt4 PE=2 SV=2 PF02146//PF01363//PF16671//PF05191//PF01428 Sir2 family//FYVE zinc finger//Actin cross-linking domain//Adenylate kinase, active site lid//AN1-like Zinc finger GO:0090527//GO:0006144//GO:0046034 actin filament reorganization//purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0004017//GO:0046872//GO:0070403 zinc ion binding//adenylate kinase activity//metal ion binding//NAD+ binding -- -- KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family) Cluster-8309.22546 BP_3 19.37 0.61 1833 478253814 ENN74106.1 498 2.1e-47 hypothetical protein YQE_09079, partial [Dendroctonus ponderosae]>gi|546684620|gb|ERL94237.1| hypothetical protein D910_11518 [Dendroctonus ponderosae] -- -- -- -- -- K03122 TFIIA1, GTF2A1, TOA1 transcription initiation factor TFIIA large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03122 P52654 180 6.6e-12 Transcription initiation factor IIA subunit 1 OS=Drosophila melanogaster GN=TfIIA-L PE=1 SV=2 PF03153//PF00728 Transcription factor IIA, alpha/beta subunit//Glycosyl hydrolase family 20, catalytic domain GO:0005975//GO:0006367 carbohydrate metabolic process//transcription initiation from RNA polymerase II promoter GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005672 transcription factor TFIIA complex KOG2652 RNA polymerase II transcription initiation factor TFIIA, large chain Cluster-8309.22547 BP_3 12.45 0.43 1699 478250692 ENN71184.1 775 1.5e-79 hypothetical protein YQE_12114, partial [Dendroctonus ponderosae]>gi|546678623|gb|ERL89205.1| hypothetical protein D910_06579 [Dendroctonus ponderosae] -- -- -- -- -- K07632 FUT4 galactoside alpha-1,3-fucosyltransferase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K07632 Q9VUL9 263 1.4e-21 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00852//PF06436 Glycosyltransferase family 10 (fucosyltransferase) C-term//Pneumovirus matrix protein 2 (M2) GO:0046782//GO:0006486 regulation of viral transcription//protein glycosylation GO:0005198//GO:0008417 structural molecule activity//fucosyltransferase activity GO:0016020//GO:0019012 membrane//virion KOG2619 Fucosyltransferase Cluster-8309.22549 BP_3 207.20 3.83 2902 189239090 XP_968540.2 1200 1.3e-128 PREDICTED: cystathionine beta-synthase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01697 E4.2.1.22, CBS cystathionine beta-synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01697 P32232 829 5.8e-87 Cystathionine beta-synthase OS=Rattus norvegicus GN=Cbs PE=1 SV=3 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- KOG1252 Cystathionine beta-synthase and related enzymes Cluster-8309.2255 BP_3 260.00 4.46 3099 91089471 XP_968843.1 1815 7.0e-200 PREDICTED: ankyrin repeat domain-containing protein 27 [Tribolium castaneum]>gi|270011402|gb|EFA07850.1| hypothetical protein TcasGA2_TC005420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMR0 942 4.9e-100 Ankyrin repeat domain-containing protein 27 OS=Mus musculus GN=Ankrd27 PE=1 SV=2 PF00023//PF13606//PF02260 Ankyrin repeat//Ankyrin repeat//FATC domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22552 BP_3 30.91 0.36 4480 560124991 CDJ90379.1 550 4.9e-53 uncharacterized protein LOC100903664 [Haemonchus contortus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05970 PIF1-like helicase GO:0006281//GO:0000723 DNA repair//telomere maintenance GO:0003678 DNA helicase activity GO:0005657 replication fork -- -- Cluster-8309.22553 BP_3 75.00 1.76 2342 642925135 XP_008194182.1 316 3.5e-26 PREDICTED: rho guanine nucleotide exchange factor 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22554 BP_3 15.95 0.60 1582 91087971 XP_973164.1 388 1.0e-34 PREDICTED: tektin-4 [Tribolium castaneum]>gi|270011906|gb|EFA08354.1| hypothetical protein TcasGA2_TC005997 [Tribolium castaneum] -- -- -- -- -- K18631 TEKT4 tektin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K18631 -- -- -- -- PF09239//PF04098 Topoisomerase VI B subunit, transducer//Rad52/22 family double-strand break repair protein GO:0006310//GO:0006265//GO:0006281 DNA recombination//DNA topological change//DNA repair GO:0003677//GO:0003918 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity -- -- -- -- Cluster-8309.22555 BP_3 15.27 0.71 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22559 BP_3 57.34 0.65 4551 820239016 BAR72977.1 1901 1.1e-209 cytochrome P450 15A1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q6R7M4 1374 5.8e-150 Methyl farnesoate epoxidase OS=Diploptera punctata GN=CYP15A1 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.22560 BP_3 716.00 184.04 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05793 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0032968//GO:0006367 positive regulation of transcription elongation from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.22561 BP_3 80.41 5.49 998 91085583 XP_968374.1 649 3.6e-65 PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|642926992|ref|XP_008195095.1| PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|270010071|gb|EFA06519.1| hypothetical protein TcasGA2_TC009422 [Tribolium castaneum] -- -- -- -- -- K06693 PSMD9 26S proteasome non-ATPase regulatory subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06693 Q9WTV5 456 3.5e-44 26S proteasome non-ATPase regulatory subunit 9 OS=Rattus norvegicus GN=Psmd9 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3129 26S proteasome regulatory complex, subunit PSMD9 Cluster-8309.22563 BP_3 12642.00 1514.68 694 158562474 ABW74143.1 323 1.6e-27 cuticular protein Ld-CP3 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F2 283 2.8e-24 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.22568 BP_3 71.77 3.57 1261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2257 BP_3 3472.85 125.93 1621 642922084 XP_008193010.1 391 4.8e-35 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270007256|gb|EFA03704.1| hypothetical protein TcasGA2_TC013809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 295 2.7e-25 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.22570 BP_3 30.32 0.32 4916 91090806 XP_970749.1 2525 5.2e-282 PREDICTED: ubiquitin-protein ligase E3B [Tribolium castaneum]>gi|270013259|gb|EFA09707.1| hypothetical protein TcasGA2_TC011840 [Tribolium castaneum] 642935863 XM_965656.2 166 1.17653e-78 PREDICTED: Tribolium castaneum ubiquitin-protein ligase E3B (LOC659339), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q7Z3V4 1869 2.5e-207 Ubiquitin-protein ligase E3B OS=Homo sapiens GN=UBE3B PE=1 SV=3 PF00612//PF00632 IQ calmodulin-binding motif//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.22571 BP_3 747.60 22.14 1919 642920075 XP_008192196.1 1574 3.8e-172 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 970 1.7e-103 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03454//PF03453 MoeA C-terminal region (domain IV)//MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.22572 BP_3 7.71 1.22 596 91094273 XP_970483.1 529 1.8e-51 PREDICTED: ethylmalonyl-CoA decarboxylase [Tribolium castaneum]>gi|270014393|gb|EFA10841.1| hypothetical protein TcasGA2_TC001618 [Tribolium castaneum] -- -- -- -- -- K18426 ECHDC1 ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K18426 F1NB38 339 7.8e-31 Ethylmalonyl-CoA decarboxylase OS=Gallus gallus GN=ECHDC1 PE=3 SV=2 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.22573 BP_3 52.91 3.29 1066 91094273 XP_970483.1 670 1.4e-67 PREDICTED: ethylmalonyl-CoA decarboxylase [Tribolium castaneum]>gi|270014393|gb|EFA10841.1| hypothetical protein TcasGA2_TC001618 [Tribolium castaneum] -- -- -- -- -- K18426 ECHDC1 ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K18426 F1NB38 394 5.9e-37 Ethylmalonyl-CoA decarboxylase OS=Gallus gallus GN=ECHDC1 PE=3 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0003824//GO:0016836 catalytic activity//hydro-lyase activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.22574 BP_3 489.47 18.41 1573 91078380 XP_974219.1 194 3.3e-12 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145//PF03310//PF02176 Seven in absentia protein family//Caulimovirus DNA-binding protein//TRAF-type zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0003677 zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.2258 BP_3 19.00 1.03 1177 122206 P01903.1 1218 4.4e-131 RecName: Full=HLA class II histocompatibility antigen, DR alpha chain; AltName: Full=MHC class II antigen DRA; Flags: Precursor>gi|307264|gb|AAA36275.1| hla-dr antigen alpha chain [Homo sapiens]>gi|307267|gb|AAA59785.1| HLA-DR alpha-chain [Homo sapiens]>gi|386945|gb|AAA36302.1| HLA-DR alpha-chain [Homo sapiens]>gi|48146143|emb|CAG33294.1| HLA-DRA [Homo sapiens]>gi|48734719|gb|AAH71659.1| Major histocompatibility complex, class II, DR alpha [Homo sapiens]>gi|119624035|gb|EAX03630.1| major histocompatibility complex, class II, DR alpha, isoform CRA_b [Homo sapiens]>gi|189053691|dbj|BAG35943.1| unnamed protein product [Homo sapiens]>gi|193227805|emb|CAP40292.1| MHC class II antigen [Homo sapiens]>gi|193227807|emb|CAP40293.1| MHC class II antigen [Homo sapiens]>gi|607346688|gb|AHW47918.1| MHC class II antigen [Homo sapiens]>gi|607346706|gb|AHW47935.1| MHC class II antigen [Homo sapiens]>gi|607346724|gb|AHW47952.1| MHC class II antigen [Homo sapiens]>gi|607346742|gb|AHW47969.1| MHC class II antigen [Homo sapiens]>gi|649119244|gb|AIC54552.1| HLA-DRA, partial [synthetic construct]>gi|223527|prf||0811251A antigen alpha,HLA DR 48734718 BC071659.1 1174 0 Homo sapiens major histocompatibility complex, class II, DR alpha, mRNA (cDNA clone MGC:87851 IMAGE:5162925), complete cds K06752 MHC2 major histocompatibility complex, class II http://www.genome.jp/dbget-bin/www_bget?ko:K06752 P01903 1218 1.8e-132 HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens GN=HLA-DRA PE=1 SV=1 PF13895//PF00993 Immunoglobulin domain//Class II histocompatibility antigen, alpha domain GO:0019882//GO:0019886//GO:0060333//GO:0050852//GO:0031295//GO:0006955 antigen processing and presentation//antigen processing and presentation of exogenous peptide antigen via MHC class II//interferon-gamma-mediated signaling pathway//T cell receptor signaling pathway//T cell costimulation//immune response GO:0032395//GO:0005515 MHC class II receptor activity//protein binding GO:0016020//GO:0030669//GO:0000139//GO:0031902//GO:0042613//GO:0005765//GO:0032588//GO:0071556//GO:0005887//GO:0012507 membrane//clathrin-coated endocytic vesicle membrane//Golgi membrane//late endosome membrane//MHC class II protein complex//lysosomal membrane//trans-Golgi network membrane//integral component of lumenal side of endoplasmic reticulum membrane//integral component of plasma membrane//ER to Golgi transport vesicle membrane -- -- Cluster-8309.22580 BP_3 618.00 37.88 1078 91095293 XP_967766.1 706 9.5e-72 PREDICTED: calcyclin-binding protein [Tribolium castaneum]>gi|270017125|gb|EFA13571.1| hypothetical protein TcasGA2_TC010306 [Tribolium castaneum] 209881974 XM_002142389.1 48 9.93104e-14 Cryptosporidium muris RN66 CS domain-containing protein, mRNA K04507 CACYBP, SIP calcyclin binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04507 Q6AYK6 458 2.2e-44 Calcyclin-binding protein OS=Rattus norvegicus GN=Cacybp PE=1 SV=1 PF00831 Ribosomal L29 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3260 Calcyclin-binding protein CacyBP Cluster-8309.22581 BP_3 543.25 6.37 4402 270013073 EFA09521.1 1113 2.5e-118 hypothetical protein TcasGA2_TC011623 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 Q5SWT3 770 6.1e-80 Solute carrier family 25 member 35 OS=Mus musculus GN=Slc25a35 PE=2 SV=2 PF01674//PF00069//PF07714 Lipase (class 2)//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016787//GO:0005524 protein kinase activity//hydrolase activity//ATP binding -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.22582 BP_3 109.86 1.84 3167 260810939 XP_002600180.1 647 1.9e-64 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NN14 484 6.4e-47 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF07776//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.22583 BP_3 170.54 1.84 4747 641665029 XP_008183228.1 514 7.7e-49 PREDICTED: zinc finger protein 600-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q02525 486 5.6e-47 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00569//PF00096//PF07776//PF07975//PF13465//PF01328//PF13912//PF02892 Zinc finger, ZZ type//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//TFIIH C1-like domain//Zinc-finger double domain//Peroxidase, family 2//C2H2-type zinc finger//BED zinc finger GO:0006979//GO:0006281//GO:0006804 response to oxidative stress//DNA repair//obsolete peroxidase reaction GO:0003677//GO:0046872//GO:0004601//GO:0008270 DNA binding//metal ion binding//peroxidase activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.22585 BP_3 41.71 0.71 3118 478255523 ENN75740.1 623 1.2e-61 hypothetical protein YQE_07700, partial [Dendroctonus ponderosae]>gi|546675929|gb|ERL87029.1| hypothetical protein D910_04431 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CR22 151 2.6e-08 Transmembrane protein 42 OS=Mus musculus GN=Tmem42 PE=2 SV=1 PF06974//PF00893//PF01146//PF00892 Protein of unknown function (DUF1298)//Small Multidrug Resistance protein//Caveolin//EamA-like transporter family GO:0042967//GO:0046486//GO:0070836 acyl-carrier-protein biosynthetic process//glycerolipid metabolic process//caveola assembly GO:0004144 diacylglycerol O-acyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.22586 BP_3 87.81 2.14 2271 478255523 ENN75740.1 623 8.5e-62 hypothetical protein YQE_07700, partial [Dendroctonus ponderosae]>gi|546675929|gb|ERL87029.1| hypothetical protein D910_04431 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06974 Protein of unknown function (DUF1298) GO:0042967//GO:0046486 acyl-carrier-protein biosynthetic process//glycerolipid metabolic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.22589 BP_3 78.68 0.56 7036 642920612 XP_008192488.1 1042 6.8e-110 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22591 BP_3 30.13 0.45 3496 642932987 XP_008197217.1 808 4.6e-83 PREDICTED: uncharacterized protein LOC103314091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05497//PF09618//PF07074 Destabilase//CRISPR-associated protein (Cas_Csy4)//Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0043571//GO:0006613//GO:0005975 maintenance of CRISPR repeat elements//cotranslational protein targeting to membrane//carbohydrate metabolic process GO:0004519//GO:0003796 endonuclease activity//lysozyme activity GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex -- -- Cluster-8309.22594 BP_3 7.00 1.01 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22596 BP_3 500.90 5.79 4464 546680010 ERL90372.1 1094 4.0e-116 hypothetical protein D910_07721 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6VMQ6 269 7.7e-22 Activating transcription factor 7-interacting protein 1 OS=Homo sapiens GN=ATF7IP PE=1 SV=3 PF17060//PF16794//PF06156 Monopolar spindle protein 2//Fibronectin-III type domain//Protein of unknown function (DUF972) GO:0030474//GO:0071988//GO:0006260 spindle pole body duplication//protein localization to spindle pole body//DNA replication GO:0005515 protein binding -- -- -- -- Cluster-8309.22597 BP_3 164.00 8.36 1237 91078792 XP_969832.1 1284 1.0e-138 PREDICTED: probable ribosome production factor 1 [Tribolium castaneum]>gi|270004111|gb|EFA00559.1| hypothetical protein TcasGA2_TC003427 [Tribolium castaneum] 766930850 XM_011499278.1 140 8.23274e-65 PREDICTED: Ceratosolen solmsi marchali probable ribosome production factor 1 (LOC105361956), mRNA K14846 RPF1 ribosome production factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14846 Q9VKB4 966 3.2e-103 Probable ribosome production factor 1 OS=Drosophila melanogaster GN=CG6712 PE=2 SV=1 PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- KOG2780 Ribosome biogenesis protein RPF1, contains IMP4 domain Cluster-8309.22601 BP_3 35.57 0.52 3577 91090906 XP_973803.1 1059 3.7e-112 PREDICTED: ras-related protein Rab-37-like isoform X2 [Tribolium castaneum] 620970185 XM_001514705.3 39 3.39016e-08 PREDICTED: Ornithorhynchus anatinus ras-related protein Rab-39B (LOC100084248), mRNA K07914 RAB37 Ras-related protein Rab-37 http://www.genome.jp/dbget-bin/www_bget?ko:K07914 Q9VP48 740 1.5e-76 Ras-related protein Rab-26 OS=Drosophila melanogaster GN=Rab26 PE=2 SV=2 PF00071//PF02421//PF04670//PF00025//PF08477//PF03193//PF01926 Ras family//Ferrous iron transport protein B//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0005525//GO:0003924 ferrous iron transmembrane transporter activity//GTP binding//GTPase activity GO:0016021 integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.22602 BP_3 75.65 2.98 1516 642910788 XP_008193411.1 458 7.7e-43 PREDICTED: uncharacterized protein LOC658122 isoform X2 [Tribolium castaneum]>gi|270015037|gb|EFA11485.1| hypothetical protein TcasGA2_TC014197 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22606 BP_3 9.40 0.75 893 546685019 ERL94584.1 166 3.3e-09 hypothetical protein D910_11861 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22607 BP_3 134.00 2.29 3113 546683517 ERL93319.1 2225 2.0e-247 hypothetical protein D910_10613 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46089 253 3.8e-20 Protein MMS22-like OS=Drosophila melanogaster GN=CG14803 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2261 BP_3 117.99 1.42 4299 642936733 XP_008198558.1 2819 0.0e+00 PREDICTED: suppressor of lurcher protein 1 [Tribolium castaneum] 642936732 XM_008200336.1 626 0 PREDICTED: Tribolium castaneum suppressor of lurcher protein 1 (LOC103314385), mRNA -- -- -- -- Q93212 607 4.7e-61 Suppressor of lurcher protein 1 OS=Caenorhabditis elegans GN=sol-1 PE=1 SV=3 PF03989 DNA gyrase C-terminal domain, beta-propeller GO:0006265 DNA topological change GO:0003916//GO:0003677//GO:0005524 DNA topoisomerase activity//DNA binding//ATP binding GO:0005694 chromosome KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.22610 BP_3 7.00 20.12 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22611 BP_3 50.97 2.48 1284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22613 BP_3 44.96 0.79 3047 642937115 XP_008198698.1 1875 7.5e-207 PREDICTED: uncharacterized protein LOC103314418 [Tribolium castaneum]>gi|270000875|gb|EEZ97322.1| hypothetical protein TcasGA2_TC011133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00004//PF00580//PF07088 ATPase family associated with various cellular activities (AAA)//UvrD/REP helicase N-terminal domain//GvpD gas vesicle protein -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.22617 BP_3 21.95 0.39 3017 91082551 XP_973940.1 2152 5.7e-239 PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|642922810|ref|XP_008193334.1| PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|642922812|ref|XP_008193335.1| PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|270007563|gb|EFA04011.1| hypothetical protein TcasGA2_TC014160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83097 756 1.8e-78 Putative tyrosine-protein kinase Wsck OS=Drosophila melanogaster GN=Wsck PE=2 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.22621 BP_3 1114.90 34.60 1845 332373514 AEE61898.1 557 3.1e-54 unknown [Dendroctonus ponderosae] 642934342 XM_008200388.1 93 1.6614e-38 PREDICTED: Tribolium castaneum uncharacterized LOC103314398 (LOC103314398), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22623 BP_3 5.00 1.88 419 390362249 XP_001190749.2 290 6.4e-24 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 227 5.3e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.22624 BP_3 19.00 1.99 753 321467243 EFX78234.1 260 3.5e-20 hypothetical protein DAPPUDRAFT_246627 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22625 BP_3 129.00 1.59 4195 390362249 XP_001190749.2 1542 4.3e-168 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q505D1 996 3.6e-106 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22628 BP_3 5.38 1.19 510 471180443 AGI05172.1 382 1.7e-34 chemosensory protein 2 [Dendroctonus ponderosae]>gi|478257979|gb|ENN78117.1| hypothetical protein YQE_05271, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 270 6.7e-23 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22630 BP_3 98.21 0.78 6397 642921412 XP_008192854.1 1114 2.8e-118 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.44674e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 791 3.2e-82 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.22636 BP_3 1.00 2.28 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22637 BP_3 75.47 0.83 4673 390362249 XP_001190749.2 755 8.6e-77 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 713 2.6e-73 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.22638 BP_3 11.48 0.63 1166 270008898 EFA05346.1 765 1.5e-78 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 435 1.1e-41 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF01920//PF13851//PF07851//PF04632//PF01297//PF00038//PF02601//PF04513//PF17078//PF04728//PF07926//PF00170//PF16740//PF06156//PF02148//PF03255 Prefoldin subunit//Growth-arrest specific micro-tubule binding//TMPIT-like protein//Fusaric acid resistance protein family//Zinc-uptake complex component A periplasmic//Intermediate filament protein//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//SWI5-dependent HO expression protein 3//Lipoprotein leucine-zipper//TPR/MLP1/MLP2-like protein//bZIP transcription factor//Spindle and kinetochore-associated protein 2//Protein of unknown function (DUF972)//Zn-finger in ubiquitin-hydrolases and other protein//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GO:0006260//GO:0006090//GO:0051301//GO:0006606//GO:0048309//GO:0048870//GO:0051028//GO:0006633//GO:0006810//GO:0007059//GO:0031110//GO:0007067//GO:0006355//GO:0000090//GO:0006457//GO:0030001//GO:0006308 DNA replication//pyruvate metabolic process//cell division//protein import into nucleus//endoplasmic reticulum inheritance//cell motility//mRNA transport//fatty acid biosynthetic process//transport//chromosome segregation//regulation of microtubule polymerization or depolymerization//mitotic nuclear division//regulation of transcription, DNA-templated//mitotic anaphase//protein folding//metal ion transport//DNA catabolic process GO:0003700//GO:0051082//GO:0046872//GO:0003989//GO:0005198//GO:0008270//GO:0043565//GO:0008855//GO:0008017 transcription factor activity, sequence-specific DNA binding//unfolded protein binding//metal ion binding//acetyl-CoA carboxylase activity//structural molecule activity//zinc ion binding//sequence-specific DNA binding//exodeoxyribonuclease VII activity//microtubule binding GO:0045298//GO:0005882//GO:0019028//GO:0016272//GO:0009318//GO:0005667//GO:0031514//GO:0016021//GO:0009317//GO:0005876//GO:0019031//GO:0019867//GO:0005886//GO:0000940 tubulin complex//intermediate filament//viral capsid//prefoldin complex//exodeoxyribonuclease VII complex//transcription factor complex//motile cilium//integral component of membrane//acetyl-CoA carboxylase complex//spindle microtubule//viral envelope//outer membrane//plasma membrane//condensed chromosome outer kinetochore KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.22639 BP_3 7.11 0.36 1244 642925663 XP_008194660.1 1239 1.7e-133 PREDICTED: BRCA1-associated protein [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 616 1.2e-62 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF12861//PF13639//PF00097//PF17122//PF02148//PF17123//PF12678//PF00628//PF14634 Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//Zn-finger in ubiquitin-hydrolases and other protein//RING-like zinc finger//RING-H2 zinc finger//PHD-finger//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0005515//GO:0046872//GO:0004842 zinc ion binding//protein binding//metal ion binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.2264 BP_3 4.00 0.52 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22641 BP_3 8.34 0.46 1174 270008898 EFA05346.1 459 4.5e-43 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q99MP8 258 3.8e-21 BRCA1-associated protein OS=Mus musculus GN=Brap PE=2 SV=1 PF02148//PF00290 Zn-finger in ubiquitin-hydrolases and other protein//Tryptophan synthase alpha chain GO:0000162//GO:0006571//GO:0006568//GO:0009094 tryptophan biosynthetic process//tyrosine biosynthetic process//tryptophan metabolic process//L-phenylalanine biosynthetic process GO:0004834//GO:0008270 tryptophan synthase activity//zinc ion binding -- -- KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.22642 BP_3 1932.28 59.39 1860 91078362 XP_973932.1 1561 1.2e-170 PREDICTED: adenosine deaminase CECR1 [Tribolium castaneum]>gi|270003977|gb|EFA00425.1| hypothetical protein TcasGA2_TC003279 [Tribolium castaneum] -- -- -- -- -- K19572 CECR1, ADA2 adenosine deaminase CECR1 http://www.genome.jp/dbget-bin/www_bget?ko:K19572 Q2VQV9 1032 1.1e-110 Adenosine deaminase CECR1 OS=Xenopus laevis GN=cecr1 PE=1 SV=1 PF00236//PF08451//PF00962 Glycoprotein hormone//Adenosine/AMP deaminase N-terminal//Adenosine/AMP deaminase GO:0007165 signal transduction GO:0005179//GO:0019239 hormone activity//deaminase activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1097 Adenine deaminase/adenosine deaminase Cluster-8309.22643 BP_3 22.72 0.80 1660 91078362 XP_973932.1 1346 9.0e-146 PREDICTED: adenosine deaminase CECR1 [Tribolium castaneum]>gi|270003977|gb|EFA00425.1| hypothetical protein TcasGA2_TC003279 [Tribolium castaneum] -- -- -- -- -- K19572 CECR1, ADA2 adenosine deaminase CECR1 http://www.genome.jp/dbget-bin/www_bget?ko:K19572 Q2VQV9 919 1.2e-97 Adenosine deaminase CECR1 OS=Xenopus laevis GN=cecr1 PE=1 SV=1 PF00962//PF00236 Adenosine/AMP deaminase//Glycoprotein hormone GO:0007165 signal transduction GO:0019239//GO:0005179 deaminase activity//hormone activity GO:0005576 extracellular region KOG1097 Adenine deaminase/adenosine deaminase Cluster-8309.22645 BP_3 5.00 0.84 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22646 BP_3 159.00 13.73 850 478252717 ENN73112.1 459 3.3e-43 hypothetical protein YQE_10253, partial [Dendroctonus ponderosae]>gi|546673855|gb|ERL85385.1| hypothetical protein D910_02805 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22649 BP_3 306.08 2.99 5233 642922353 XP_008193121.1 1173 3.3e-125 PREDICTED: male-specific lethal 1 homolog [Tribolium castaneum] -- -- -- -- -- K13163 MSL1 male-specific lethal 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13163 A9JRX0 283 2.1e-23 Male-specific lethal 1-like 1 OS=Danio rerio GN=msl1l1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22651 BP_3 619.31 29.46 1305 642918168 XP_968046.3 1065 2.7e-113 PREDICTED: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K12663 ECH1 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K12663 Q62651 776 3.6e-81 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Rattus norvegicus GN=Ech1 PE=1 SV=2 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1681 Enoyl-CoA isomerase Cluster-8309.22652 BP_3 60.93 1.05 3079 91083715 XP_970185.1 1197 3.2e-128 PREDICTED: RNA-binding protein 45 [Tribolium castaneum]>gi|270007883|gb|EFA04331.1| hypothetical protein TcasGA2_TC014625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUH3 567 1.5e-56 RNA-binding protein 45 OS=Homo sapiens GN=RBM45 PE=1 SV=1 PF16367//PF00076//PF08675//PF08777//PF14552 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain//RNA binding motif//Tautomerase enzyme GO:0006402//GO:0051252//GO:0006725 mRNA catabolic process//regulation of RNA metabolic process//cellular aromatic compound metabolic process GO:0016853//GO:0003723//GO:0046872//GO:0003676//GO:0004535//GO:1901363//GO:0097159 isomerase activity//RNA binding//metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity//heterocyclic compound binding//organic cyclic compound binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.22653 BP_3 537.49 8.14 3475 478250819 ENN71311.1 810 2.7e-83 hypothetical protein YQE_12236, partial [Dendroctonus ponderosae]>gi|546679724|gb|ERL90139.1| hypothetical protein D910_07493 [Dendroctonus ponderosae] -- -- -- -- -- K14775 UTP30, RSL1D1 ribosome biogenesis protein UTP30 http://www.genome.jp/dbget-bin/www_bget?ko:K14775 Q9VLK2 333 2.3e-29 Ribosomal L1 domain-containing protein CG13096 OS=Drosophila melanogaster GN=CG13096 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22656 BP_3 70.80 1.06 3498 642924747 XP_008194424.1 3968 0.0e+00 PREDICTED: tyrosine-protein kinase PR2 isoform X3 [Tribolium castaneum] 462376521 APGK01023661.1 50 2.54422e-14 Dendroctonus ponderosae Seq01023671, whole genome shotgun sequence -- -- -- -- Q9I7F7 1702 4.1e-188 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF14604//PF00018//PF00069//PF07714 Variant SH3 domain//SH3 domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding -- -- KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.22659 BP_3 949.00 18.01 2831 91090602 XP_972981.1 1139 1.5e-121 PREDICTED: MOB kinase activator-like 4 [Tribolium castaneum]>gi|270013903|gb|EFA10351.1| hypothetical protein TcasGA2_TC012571 [Tribolium castaneum] 820865569 XM_003698745.2 231 4.95751e-115 PREDICTED: Apis florea MOB kinase activator-like 4 (LOC100868901), transcript variant X1, mRNA -- -- -- -- Q7K0E3 1056 2.7e-113 MOB kinase activator-like 4 OS=Drosophila melanogaster GN=Mob4 PE=2 SV=1 PF02060 Slow voltage-gated potassium channel GO:0006811//GO:0006813 ion transport//potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0008076//GO:0016020 voltage-gated potassium channel complex//membrane KOG1852 Cell cycle-associated protein Cluster-8309.22662 BP_3 9.10 1.78 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22663 BP_3 321.33 29.32 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22665 BP_3 35.06 1.18 1726 642924856 XP_008194068.1 1307 3.1e-141 PREDICTED: trypsin-3 [Tribolium castaneum]>gi|270008121|gb|EFA04569.1| serine protease P133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81286 420 9.2e-40 Plasminogen (Fragment) OS=Ovis aries GN=PLG PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.22667 BP_3 4.49 1.60 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22669 BP_3 186.60 2.96 3333 270003223 EEZ99670.1 2222 4.8e-247 hypothetical protein TcasGA2_TC002427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00514//PF11698//PF00651 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//BTB/POZ domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.22676 BP_3 7.62 0.75 783 91078608 XP_967155.1 398 3.6e-36 PREDICTED: mitochondrial import inner membrane translocase subunit Tim10 [Tribolium castaneum]>gi|270004056|gb|EFA00504.1| hypothetical protein TcasGA2_TC003366 [Tribolium castaneum] -- -- -- -- -- K17778 TIM10 mitochondrial import inner membrane translocase subunit TIM10 http://www.genome.jp/dbget-bin/www_bget?ko:K17778 Q9W2D6 317 3.6e-28 Mitochondrial import inner membrane translocase subunit Tim10 OS=Drosophila melanogaster GN=Tim10 PE=3 SV=1 -- -- GO:0045039 protein import into mitochondrial inner membrane GO:0046872 metal ion binding GO:0042719//GO:0005743 mitochondrial intermembrane space protein transporter complex//mitochondrial inner membrane KOG3480 Mitochondrial import inner membrane translocase, subunits TIM10/TIM12 Cluster-8309.22678 BP_3 76.00 2.86 1571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00342 Phosphoglucose isomerase GO:0005985//GO:0006094//GO:0006096//GO:0005982//GO:0006098 sucrose metabolic process//gluconeogenesis//glycolytic process//starch metabolic process//pentose-phosphate shunt GO:0004347 glucose-6-phosphate isomerase activity -- -- -- -- Cluster-8309.22681 BP_3 147.00 2.11 3643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22682 BP_3 37.97 0.34 5599 546670689 ERL83353.1 2300 7.3e-256 hypothetical protein D910_00267 [Dendroctonus ponderosae]>gi|546675709|gb|ERL86848.1| hypothetical protein D910_04251 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9C0E2 797 5.7e-83 Exportin-4 OS=Homo sapiens GN=XPO4 PE=1 SV=2 PF05066//PF03810//PF06777 HB1, ASXL, restriction endonuclease HTH domain//Importin-beta N-terminal domain//Helical and beta-bridge domain GO:0006886//GO:0006351//GO:0006355 intracellular protein transport//transcription, DNA-templated//regulation of transcription, DNA-templated GO:0008536 Ran GTPase binding GO:0005634 nucleus KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily) Cluster-8309.22685 BP_3 315.68 8.24 2139 642911136 XP_008200596.1 1380 1.3e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 6.8e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22689 BP_3 128.44 2.65 2626 642920766 XP_008192551.1 1683 1.2e-184 PREDICTED: translation factor GUF1 homolog, mitochondrial isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0WXB8 1437 1.6e-157 Translation factor GUF1 homolog, mitochondrial OS=Culex quinquefasciatus GN=CPIJ012086 PE=3 SV=1 PF06377//PF03144//PF01386 Adipokinetic hormone//Elongation factor Tu domain 2//Ribosomal L25p family GO:0042254//GO:0007165//GO:0006412 ribosome biogenesis//signal transduction//translation GO:0005525//GO:0003735//GO:0008097//GO:0005179 GTP binding//structural constituent of ribosome//5S rRNA binding//hormone activity GO:0005840 ribosome KOG0462 Elongation factor-type GTP-binding protein Cluster-8309.22690 BP_3 156.24 2.14 3811 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.9e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22692 BP_3 337.31 4.90 3607 270297218 NP_001161918.1 475 2.0e-44 cuticular protein analogous to peritrophins 1-H precursor [Tribolium castaneum]>gi|642929138|ref|XP_008195708.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|642929140|ref|XP_008195709.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|268309014|gb|ACY95473.1| cuticular protein analogous to peritrophins 1-H [Tribolium castaneum]>gi|270010495|gb|EFA06943.1| hypothetical protein TcasGA2_TC009894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03110//PF10717 SBP domain//Occlusion-derived virus envelope protein ODV-E18 -- -- GO:0003677 DNA binding GO:0005634//GO:0019031 nucleus//viral envelope -- -- Cluster-8309.22694 BP_3 26.00 0.41 3366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22695 BP_3 50.00 0.77 3431 546686193 ERL95573.1 1453 7.3e-158 hypothetical protein D910_12834 [Dendroctonus ponderosae] -- -- -- -- -- K00109 E1.1.99.2 2-hydroxyglutarate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00109 A7SMW7 1249 1.4e-135 L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Nematostella vectensis GN=v1g172254 PE=3 SV=1 PF05834//PF07992//PF01266//PF03435//PF01494//PF06039//PF02254 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//FAD binding domain//Malate:quinone oxidoreductase (Mqo)//TrkA-N domain GO:0006813//GO:0006090//GO:0016117//GO:0006099//GO:0055114 potassium ion transport//pyruvate metabolic process//carotenoid biosynthetic process//tricarboxylic acid cycle//oxidation-reduction process GO:0071949//GO:0016705//GO:0016491//GO:0008924 FAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//malate dehydrogenase (quinone) activity -- -- KOG2665 Predicted FAD-dependent oxidoreductase Cluster-8309.22699 BP_3 9.11 0.61 1011 665794141 XP_008544754.1 671 1.0e-67 PREDICTED: pseudouridine-5'-monophosphatase isoform X1 [Microplitis demolitor] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 623 1.5e-63 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 PF12162 STAT1 TAZ2 binding domain -- -- GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.2270 BP_3 17.00 0.78 1348 270015896 EFA12344.1 604 8.0e-60 hypothetical protein TcasGA2_TC001858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 220 1.1e-16 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665//PF09392 Integrase core domain//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0009405//GO:0015031//GO:0015074 pathogenesis//protein transport//DNA integration -- -- -- -- -- -- Cluster-8309.22700 BP_3 61.63 3.23 1211 270000732 EEZ97179.1 935 3.0e-98 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] -- -- -- -- -- K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 464 5.1e-45 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 PF06220//PF00096//PF03153 U1 zinc finger//Zinc finger, C2H2 type//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.22705 BP_3 142.74 0.93 7705 642921434 XP_008192864.1 2907 0.0e+00 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P86410 1323 8.0e-144 Ral GTPase-activating protein subunit beta OS=Rattus norvegicus GN=Ralgapb PE=1 SV=1 PF02145//PF00876//PF00237 Rap/ran-GAP//Innexin//Ribosomal protein L22p/L17e GO:0042254//GO:0006412//GO:0051056 ribosome biogenesis//translation//regulation of small GTPase mediated signal transduction GO:0003735//GO:0005096 structural constituent of ribosome//GTPase activator activity GO:0005840//GO:0005921 ribosome//gap junction KOG1711 Mitochondrial/chloroplast ribosomal protein L22 Cluster-8309.22706 BP_3 35.67 1.15 1787 91093659 XP_966349.1 295 7.2e-24 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] -- -- -- -- -- K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 Q9W3K5 229 1.3e-17 Glutamate--cysteine ligase OS=Drosophila melanogaster GN=Gclc PE=2 SV=1 PF03074 Glutamate-cysteine ligase GO:0006749//GO:0006750 glutathione metabolic process//glutathione biosynthetic process GO:0004357 glutamate-cysteine ligase activity GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.22707 BP_3 47.76 0.92 2796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22710 BP_3 112.99 1.32 4424 642922521 XP_008193210.1 2802 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1116 4.6e-120 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF02985//PF00514 HEAT repeat//Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.22711 BP_3 75.31 1.09 3619 642922521 XP_008193210.1 3268 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1353 1.2e-147 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF00514//PF02985 Armadillo/beta-catenin-like repeat//HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.22713 BP_3 50.73 1.39 2052 642911136 XP_008200596.1 1383 5.7e-150 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 6.5e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22714 BP_3 16.88 1.20 968 642911138 XP_971944.3 359 1.5e-31 PREDICTED: mitochondrial folate transporter/carrier isoform X2 [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 212 6.8e-16 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22715 BP_3 151.20 3.71 2254 642911136 XP_008200596.1 1379 1.8e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 7.2e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22716 BP_3 159.28 15.16 798 189236866 XP_001814181.1 265 9.7e-21 PREDICTED: LIRP [Tribolium castaneum]>gi|270006348|gb|EFA02796.1| insulin-like peptide [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15131 180 2.9e-12 LIRP OS=Locusta migratoria PE=1 SV=2 PF00049//PF03488 Insulin/IGF/Relaxin family//Nematode insulin-related peptide beta type GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.22717 BP_3 10.00 0.73 948 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22718 BP_3 86.79 0.82 5401 642938541 XP_008199834.1 1799 8.7e-198 PREDICTED: transcription factor Ken isoform X1 [Tribolium castaneum]>gi|270015579|gb|EFA12027.1| hypothetical protein TcasGA2_TC001442 [Tribolium castaneum] 642938542 XM_008201613.1 75 4.99314e-28 PREDICTED: Tribolium castaneum transcription factor Ken (LOC656389), transcript variant X2, mRNA -- -- -- -- Q292R5 588 9.5e-59 Transcription factor Ken OS=Drosophila pseudoobscura pseudoobscura GN=ken PE=3 SV=2 PF00081//PF00651//PF13912//PF00096//PF13465 Iron/manganese superoxide dismutases, alpha-hairpin domain//BTB/POZ domain//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006801//GO:0055114 superoxide metabolic process//oxidation-reduction process GO:0005515//GO:0004784//GO:0003676//GO:0008270//GO:0046872 protein binding//superoxide dismutase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.2272 BP_3 6.00 0.71 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22723 BP_3 51.09 0.52 5019 478252787 ENN73180.1 1403 6.7e-152 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 5.8e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 PF03083 Sugar efflux transporter for intercellular exchange -- -- -- -- GO:0016021 integral component of membrane KOG4780 Uncharacterized conserved protein Cluster-8309.22724 BP_3 98.00 6.47 1022 270002473 EEZ98920.1 285 5.9e-23 hypothetical protein TcasGA2_TC004539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P24014 203 7.9e-15 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22725 BP_3 97.29 2.51 2162 642924692 XP_008194400.1 1129 1.7e-120 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 257 9.1e-21 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22726 BP_3 243.44 1.97 6249 373159261 AEY63780.1 2481 8.3e-277 ecdysone receptor isoform A [Monochamus alternatus] 373159260 JN616374.1 1422 0 Monochamus alternatus ecdysone receptor isoform A mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 P49880 1355 1.3e-147 Ecdysone receptor OS=Aedes aegypti GN=EcR PE=1 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.22728 BP_3 8.57 0.37 1420 91087659 XP_973571.1 774 1.6e-79 PREDICTED: proteasome subunit beta type-6 [Tribolium castaneum]>gi|270009417|gb|EFA05865.1| hypothetical protein TcasGA2_TC008665 [Tribolium castaneum] -- -- -- -- -- K02738 PSMB6 20S proteasome subunit beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02738 Q3MHN0 580 2.1e-58 Proteasome subunit beta type-6 OS=Bos taurus GN=PSMB6 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005634//GO:0005839//GO:0005737 nucleus//proteasome core complex//cytoplasm KOG0174 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 Cluster-8309.22730 BP_3 16.75 1.41 865 478258155 ENN78293.1 398 4.0e-36 hypothetical protein YQE_05443, partial [Dendroctonus ponderosae]>gi|546682829|gb|ERL92718.1| hypothetical protein D910_10028 [Dendroctonus ponderosae] -- -- -- -- -- K17339 ATL atlastin http://www.genome.jp/dbget-bin/www_bget?ko:K17339 Q9VC57 314 9.0e-28 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2037 Guanylate-binding protein Cluster-8309.22731 BP_3 286.49 10.04 1667 91090264 XP_970269.1 888 1.2e-92 PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934841|ref|XP_008197832.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934843|ref|XP_008197833.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934845|ref|XP_008197834.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|270013784|gb|EFA10232.1| hypothetical protein TcasGA2_TC012429 [Tribolium castaneum] 780638303 XM_011689036.1 101 5.34984e-43 PREDICTED: Wasmannia auropunctata E3 ubiquitin-protein ligase RNF185-like (LOC105449687), transcript variant X4, mRNA K10666 RNF5 E3 ubiquitin-protein ligase RNF5 http://www.genome.jp/dbget-bin/www_bget?ko:K10666 Q5ZIR9 677 1.4e-69 E3 ubiquitin-protein ligase RNF185 OS=Gallus gallus GN=RNF185 PE=2 SV=1 PF13639//PF00097//PF14634//PF12861//PF12678//PF17123 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//RING-like zinc finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex KOG0823 Predicted E3 ubiquitin ligase Cluster-8309.22732 BP_3 25.00 1.71 998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22733 BP_3 1.00 2.87 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22734 BP_3 534.58 9.19 3096 642917468 XP_008191214.1 2797 0.0e+00 PREDICTED: ral guanine nucleotide dissociation stimulator-like 1 isoform X6 [Tribolium castaneum] -- -- -- -- -- K17635 RGL1, RGL ral guanine nucleotide dissociation stimulator-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17635 Q9NZL6 962 2.3e-102 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00788//PF00617 Ras association (RalGDS/AF-6) domain//RasGEF domain GO:0007165//GO:0043087//GO:0007264 signal transduction//regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.22735 BP_3 17.76 0.61 1700 332376529 AEE63404.1 1508 1.5e-164 unknown [Dendroctonus ponderosae]>gi|478253680|gb|ENN73982.1| hypothetical protein YQE_09437, partial [Dendroctonus ponderosae]>gi|546684422|gb|ERL94065.1| hypothetical protein D910_11348 [Dendroctonus ponderosae] 676438341 XM_009050250.1 51 3.40315e-15 Lottia gigantea hypothetical protein mRNA K11652 ACTL6B actin-like protein 6B http://www.genome.jp/dbget-bin/www_bget?ko:K11652 P86173 905 5.2e-96 Actin-like protein 6B OS=Rattus norvegicus GN=Actl6b PE=1 SV=2 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0679 Actin-related protein - Arp4p/Act3p Cluster-8309.22740 BP_3 36.92 0.78 2569 741829513 AJA91072.1 1444 6.0e-157 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 1018 6.2e-109 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.22744 BP_3 51.89 2.72 1211 780089478 XP_011673857.1 462 2.1e-43 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- K08803 DAPK death-associated protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08803 Q4UMH6 363 2.6e-33 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF05396//PF08052 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein//PyrBI operon leader peptide GO:0019069//GO:0019856 viral capsid assembly//pyrimidine nucleobase biosynthetic process GO:0005515 protein binding -- -- -- -- Cluster-8309.22745 BP_3 2.00 10.05 263 -- -- -- -- -- 530723032 KC131028.1 199 2.51027e-98 Portunus trituberculatus skeletal muscle actin 2 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22746 BP_3 117.78 1.08 5560 270012402 EFA08850.1 3240 0.0e+00 hypothetical protein TcasGA2_TC006551 [Tribolium castaneum] 642932661 XM_008198715.1 84 5.10488e-33 PREDICTED: Tribolium castaneum inactive rhomboid protein 1 (LOC658816), mRNA -- -- -- -- Q76NQ1 1377 3.2e-150 Inactive rhomboid protein 1 OS=Drosophila melanogaster GN=rho-5 PE=2 SV=1 PF01694 Rhomboid family -- -- GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2290 Rhomboid family proteins Cluster-8309.22747 BP_3 441.00 18.77 1424 546679385 ERL89860.1 1430 1.4e-155 hypothetical protein D910_07219 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B3NQR5 1277 3.2e-139 Probable cytosolic iron-sulfur protein assembly protein Ciao1 OS=Drosophila erecta GN=Ciao1 PE=3 SV=1 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0645 WD40 repeat protein Cluster-8309.2275 BP_3 1.00 0.61 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22750 BP_3 2.00 2.45 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22752 BP_3 9.00 1.83 529 817061123 XP_012252151.1 166 1.9e-09 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00165//PF03193 Bacterial regulatory helix-turn-helix proteins, AraC family//Protein of unknown function, DUF258 GO:0006355 regulation of transcription, DNA-templated GO:0005525//GO:0043565//GO:0003924//GO:0003700 GTP binding//sequence-specific DNA binding//GTPase activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.22754 BP_3 27.40 1.01 1599 642915291 XP_008190557.1 682 8.6e-69 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 379 4.8e-35 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22755 BP_3 563.29 4.15 6835 642917395 XP_008191178.1 2504 2.0e-279 PREDICTED: DNA ligase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 P51892 2125 7.1e-237 DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1 PF04679//PF04675//PF00515//PF13414//PF01331//PF13181//PF13174//PF01068 ATP dependent DNA ligase C terminal region//DNA ligase N terminus//Tetratricopeptide repeat//TPR repeat//mRNA capping enzyme, catalytic domain//Tetratricopeptide repeat//Tetratricopeptide repeat//ATP dependent DNA ligase domain GO:0006281//GO:0006397//GO:0006310//GO:0006370//GO:0006260 DNA repair//mRNA processing//DNA recombination//7-methylguanosine mRNA capping//DNA replication GO:0004484//GO:0005515//GO:0005524//GO:0003677//GO:0003910 mRNA guanylyltransferase activity//protein binding//ATP binding//DNA binding//DNA ligase (ATP) activity -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.22757 BP_3 209.22 1.54 6853 815910998 XP_012241008.1 2504 2.0e-279 PREDICTED: DNA ligase 1 isoform X2 [Bombus impatiens] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 P51892 2120 2.7e-236 DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1 PF13181//PF01068//PF13174//PF00515//PF04675//PF04679//PF13414//PF01331 Tetratricopeptide repeat//ATP dependent DNA ligase domain//Tetratricopeptide repeat//Tetratricopeptide repeat//DNA ligase N terminus//ATP dependent DNA ligase C terminal region//TPR repeat//mRNA capping enzyme, catalytic domain GO:0006370//GO:0006310//GO:0006260//GO:0006281//GO:0006397 7-methylguanosine mRNA capping//DNA recombination//DNA replication//DNA repair//mRNA processing GO:0003910//GO:0005515//GO:0004484//GO:0005524//GO:0003677 DNA ligase (ATP) activity//protein binding//mRNA guanylyltransferase activity//ATP binding//DNA binding -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.22759 BP_3 77.27 2.35 1875 642925505 XP_008194578.1 1307 3.4e-141 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase [Tribolium castaneum]>gi|270008695|gb|EFA05143.1| hypothetical protein TcasGA2_TC015260 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q7SY06 621 4.9e-63 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio GN=hacd3 PE=2 SV=2 PF06687 SUR7/PalI family -- -- -- -- GO:0005886 plasma membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.2276 BP_3 33.00 2.54 919 321462347 EFX73371.1 879 7.1e-92 hypothetical protein DAPPUDRAFT_231352 [Daphnia pulex] 262401292 FJ774828.1 311 5.30082e-160 Scylla paramamosain ribosomal protein L7Ae mRNA, partial cds K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P46223 798 7.2e-84 60S ribosomal protein L7a OS=Drosophila melanogaster GN=RpL7A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8309.22761 BP_3 2.00 1.05 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04625 DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213 structural constituent of chorion GO:0005576//GO:0042600 extracellular region//chorion -- -- Cluster-8309.22763 BP_3 34.00 0.82 2284 768196859 KJH52544.1 185 5.2e-11 c-terminal tandem repeated domain in type 4 procollagen [Dictyocaulus viviparus] -- -- -- -- -- K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 P27393 171 9.1e-11 Collagen alpha-2(IV) chain OS=Ascaris suum PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.22765 BP_3 241.89 12.70 1210 91081553 XP_975065.1 969 3.4e-102 PREDICTED: RWD domain-containing protein 2A [Tribolium castaneum]>gi|270006181|gb|EFA02629.1| hypothetical protein TcasGA2_TC008349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UIY3 542 4.6e-54 RWD domain-containing protein 2A OS=Homo sapiens GN=RWDD2A PE=1 SV=1 PF05424//PF05773 Duffy binding domain//RWD domain GO:0007165//GO:0009405 signal transduction//pathogenesis GO:0005515//GO:0004872 protein binding//receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22766 BP_3 21.21 0.48 2429 642934168 XP_008199635.1 1279 7.8e-138 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.7599e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 Q5ZKY2 815 2.0e-85 Ubiquitin-like modifier-activating enzyme ATG7 OS=Gallus gallus GN=ATG7 PE=2 SV=1 PF00899//PF02826//PF02558//PF13241 ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Ketopantoate reductase PanE/ApbA//Putative NAD(P)-binding GO:0055114//GO:0006779//GO:0019354//GO:0015940 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//pantothenate biosynthetic process GO:0008641//GO:0008677//GO:0051287//GO:0043115 small protein activating enzyme activity//2-dehydropantoate 2-reductase activity//NAD binding//precorrin-2 dehydrogenase activity -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.2277 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22771 BP_3 102.39 1.23 4301 642940435 XP_008194234.1 2341 9.8e-261 PREDICTED: rho GTPase-activating protein 26, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMW5 1504 4.6e-165 Rho GTPase-activating protein 26 OS=Gallus gallus GN=ARHGAP26 PE=1 SV=2 PF03114//PF00620//PF01297//PF01956//PF03155 BAR domain//RhoGAP domain//Zinc-uptake complex component A periplasmic//Integral membrane protein DUF106//ALG6, ALG8 glycosyltransferase family GO:0007165//GO:0030001 signal transduction//metal ion transport GO:0046872//GO:0005515//GO:0016758 metal ion binding//protein binding//transferase activity, transferring hexosyl groups GO:0005737//GO:0016020//GO:0005789 cytoplasm//membrane//endoplasmic reticulum membrane KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins Cluster-8309.22772 BP_3 10.45 0.56 1189 478253166 ENN73537.1 199 6.5e-13 hypothetical protein YQE_09788, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 148 2.2e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF04183 Zinc finger, C2H2 type//Zinc-finger double domain//IucA / IucC family GO:0006826//GO:0019290 iron ion transport//siderophore biosynthetic process GO:0046872//GO:0015343 metal ion binding//siderophore transmembrane transporter activity -- -- -- -- Cluster-8309.22774 BP_3 3.00 0.42 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22775 BP_3 6.80 1.66 489 642914773 XP_008190345.1 368 6.7e-33 PREDICTED: protein SERAC1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SNQ7 185 4.6e-13 Protein SERAC1 OS=Danio rerio GN=serac1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22778 BP_3 965.98 6.77 7165 91093773 XP_966763.1 2305 2.4e-256 PREDICTED: KAT8 regulatory NSL complex subunit 1 [Tribolium castaneum]>gi|270015922|gb|EFA12370.1| hypothetical protein TcasGA2_TC002076 [Tribolium castaneum] 462418059 APGK01017125.1 89 1.09415e-35 Dendroctonus ponderosae Seq01017135, whole genome shotgun sequence K18400 KANSL1 KAT8 regulatory NSL complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18400 Q80TG1 409 7.2e-38 KAT8 regulatory NSL complex subunit 1 OS=Mus musculus GN=Kansl1 PE=2 SV=1 PF07544//PF06009//PF17064//PF08651 RNA polymerase II transcription mediator complex subunit 9//Laminin Domain II//Sleepless protein//DASH complex subunit Duo1 GO:0032222//GO:0007067//GO:0007155//GO:0006357//GO:0030431//GO:1903818 regulation of synaptic transmission, cholinergic//mitotic nuclear division//cell adhesion//regulation of transcription from RNA polymerase II promoter//sleep//positive regulation of voltage-gated potassium channel activity GO:0001104//GO:0034235 RNA polymerase II transcription cofactor activity//GPI anchor binding GO:0042729//GO:0016592//GO:0072686 DASH complex//mediator complex//mitotic spindle -- -- Cluster-8309.22779 BP_3 237.00 3.43 3621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00435//PF06368 Spectrin repeat//Methylaspartate mutase E chain (MutE) GO:0019670 anaerobic glutamate catabolic process GO:0005515//GO:0050097 protein binding//methylaspartate mutase activity -- -- -- -- Cluster-8309.2278 BP_3 20.00 1.21 1091 390335172 XP_783048.2 1328 7.2e-144 PREDICTED: phosphate carrier protein, mitochondrial [Strongylocentrotus purpuratus] 780165995 XM_777955.4 228 8.72812e-114 PREDICTED: Strongylocentrotus purpuratus phosphate carrier protein, mitochondrial (LOC577743), mRNA K15102 SLC25A3, PHC, PIC solute carrier family 25 (mitochondrial phosphate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15102 Q5R7W2 1273 7.1e-139 Phosphate carrier protein, mitochondrial OS=Pongo abelii GN=SLC25A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0767 Mitochondrial phosphate carrier protein Cluster-8309.22782 BP_3 15.01 0.31 2651 270013970 EFA10418.1 447 2.5e-41 hypothetical protein TcasGA2_TC012658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22783 BP_3 183.05 5.87 1796 642911711 XP_970705.2 1511 7.2e-165 PREDICTED: solute carrier family 25 member 46-like [Tribolium castaneum]>gi|270014568|gb|EFA11016.1| hypothetical protein TcasGA2_TC004603 [Tribolium castaneum] -- -- -- -- -- K03454 SLC25A46 solute carrier family 25, member 46 http://www.genome.jp/dbget-bin/www_bget?ko:K03454 Q5ZIG3 713 1.0e-73 Solute carrier family 25 member 46 OS=Gallus gallus GN=SLC25A46 PE=2 SV=1 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG2954 Mitochondrial carrier protein Cluster-8309.22787 BP_3 38.00 1.17 1863 -- -- -- -- -- 392303553 JX102586.1 621 0 Scylla paramamosain microsatellite Spm15 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22788 BP_3 359.22 14.17 1514 91092262 XP_967283.1 1627 2.1e-178 PREDICTED: methionine aminopeptidase 1 [Tribolium castaneum]>gi|270001228|gb|EEZ97675.1| hypothetical protein TcasGA2_TC016220 [Tribolium castaneum] 746858202 XM_011061556.1 236 4.36016e-118 PREDICTED: Acromyrmex echinatior methionine aminopeptidase 1 (LOC105149265), transcript variant X2, mRNA K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q4QRK0 1232 5.6e-134 Methionine aminopeptidase 1 OS=Danio rerio GN=metap1 PE=2 SV=2 -- -- GO:0009987//GO:0006508 cellular process//proteolysis GO:0046872//GO:0004177//GO:0008270//GO:0008235 metal ion binding//aminopeptidase activity//zinc ion binding//metalloexopeptidase activity -- -- KOG2738 Putative methionine aminopeptidase Cluster-8309.22791 BP_3 2.00 0.49 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22792 BP_3 31.00 37.97 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22795 BP_3 14.00 1.09 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22796 BP_3 24.15 39.88 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22797 BP_3 61.85 4.04 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.228 BP_3 27.00 1.17 1400 642919561 XP_008191924.1 648 6.6e-65 PREDICTED: cholecystokinin receptor type A-like [Tribolium castaneum]>gi|482678622|gb|AGK29938.1| sulfakinin receptor 1, partial [Tribolium castaneum] 61967918 AY865608.1 105 2.67402e-45 Periplaneta americana perisulfakinin receptor mRNA, complete cds K04196 CCKLR cholecystokinin-like receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04196 P70031 258 4.5e-21 Cholecystokinin receptor OS=Xenopus laevis GN=cckar PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.2280 BP_3 13.84 0.65 1319 642923040 XP_973485.2 1107 3.7e-118 PREDICTED: transmembrane protein 164 [Tribolium castaneum]>gi|642923042|ref|XP_008200506.1| PREDICTED: transmembrane protein 164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PHN7 483 3.5e-47 Transmembrane protein 164 OS=Mus musculus GN=Tmem164 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22800 BP_3 38.00 1.14 1900 304441899 ADM34185.1 476 7.9e-45 myosin light chain [Penaeus monodon] -- -- -- -- -- K12757 MYL12 myosin regulatory light chain 12 http://www.genome.jp/dbget-bin/www_bget?ko:K12757 Q1HPS0 442 2.8e-42 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF13499//PF13833//PF13405//PF04625//PF01213//PF01299//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//EF-hand domain//DEC-1 protein, N-terminal region//Adenylate cyclase associated (CAP) N terminal//Lysosome-associated membrane glycoprotein (Lamp)//EF hand//EF hand GO:0007010//GO:0007304 cytoskeleton organization//chorion-containing eggshell formation GO:0003779//GO:0005213//GO:0005509 actin binding//structural constituent of chorion//calcium ion binding GO:0042600//GO:0016020//GO:0005576 chorion//membrane//extracellular region KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.22801 BP_3 93.92 12.67 649 642913478 XP_008201029.1 580 2.3e-57 PREDICTED: dolichol kinase [Tribolium castaneum] -- -- -- -- -- K00902 E2.7.1.108 dolichol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00902 Q8R2Y3 336 1.9e-30 Dolichol kinase OS=Mus musculus GN=Dolk PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2468 Dolichol kinase Cluster-8309.22802 BP_3 8.84 0.35 1516 91094103 XP_967297.1 1386 1.9e-150 PREDICTED: trafficking protein particle complex subunit 13 [Tribolium castaneum]>gi|270010876|gb|EFA07324.1| hypothetical protein TcasGA2_TC015920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VFT9 926 1.7e-98 Trafficking protein particle complex subunit 13 OS=Xenopus tropicalis GN=trappc13 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2625 Uncharacterized conserved protein Cluster-8309.22803 BP_3 184.63 1.59 5884 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 6.1e-261 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.22806 BP_3 395.81 7.60 2801 657592270 XP_008300654.1 354 1.6e-30 PREDICTED: zinc finger protein 345-like isoform X1 [Stegastes partitus] -- -- -- -- -- -- -- -- -- Q8TC21 320 5.9e-28 Zinc finger protein 596 OS=Homo sapiens GN=ZNF596 PE=2 SV=2 PF00096//PF13465//PF07776//PF10426//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//Recombination-activating protein 1 zinc-finger domain//C2H2-type zinc finger -- -- GO:0016788//GO:0008270//GO:0016881//GO:0046872 hydrolase activity, acting on ester bonds//zinc ion binding//acid-amino acid ligase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.22807 BP_3 13.97 0.94 1010 255522809 NP_001157317.1 158 3.1e-08 longitudinals lacking isoform 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 135 6.0e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF01022//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Bacterial regulatory protein, arsR family//BED zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003700//GO:0003677 metal ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.22809 BP_3 335.78 4.39 3979 91082499 XP_972877.1 3022 0.0e+00 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] 642922743 XM_967784.2 69 7.94352e-25 PREDICTED: Tribolium castaneum nuclear pore complex protein Nup93 (LOC661634), mRNA K14309 NUP93, NIC96 nuclear pore complex protein Nup93 http://www.genome.jp/dbget-bin/www_bget?ko:K14309 Q6NX12 1496 3.6e-164 Nuclear pore complex protein Nup93 OS=Xenopus tropicalis GN=nup93 PE=2 SV=1 PF05834//PF04097 Lycopene cyclase protein//Nup93/Nic96 GO:0006810//GO:0016117 transport//carotenoid biosynthetic process GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005643 nuclear pore KOG1235 Predicted unusual protein kinase Cluster-8309.22812 BP_3 31.81 0.39 4251 91082499 XP_972877.1 3022 0.0e+00 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] 642922743 XM_967784.2 69 8.49148e-25 PREDICTED: Tribolium castaneum nuclear pore complex protein Nup93 (LOC661634), mRNA K14309 NUP93, NIC96 nuclear pore complex protein Nup93 http://www.genome.jp/dbget-bin/www_bget?ko:K14309 Q6NX12 1496 3.8e-164 Nuclear pore complex protein Nup93 OS=Xenopus tropicalis GN=nup93 PE=2 SV=1 PF04097 Nup93/Nic96 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1235 Predicted unusual protein kinase Cluster-8309.22813 BP_3 6.45 0.33 1233 642918646 XP_008200444.1 474 8.7e-45 PREDICTED: uncharacterized aarF domain-containing protein kinase 5 [Tribolium castaneum] -- -- -- -- -- K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 Q80V03 344 4.2e-31 Uncharacterized aarF domain-containing protein kinase 5 OS=Mus musculus GN=Adck5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1235 Predicted unusual protein kinase Cluster-8309.22815 BP_3 395.89 4.89 4194 91082499 XP_972877.1 3022 0.0e+00 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] 642922743 XM_967784.2 69 8.37665e-25 PREDICTED: Tribolium castaneum nuclear pore complex protein Nup93 (LOC661634), mRNA K14309 NUP93, NIC96 nuclear pore complex protein Nup93 http://www.genome.jp/dbget-bin/www_bget?ko:K14309 Q6NX12 1496 3.8e-164 Nuclear pore complex protein Nup93 OS=Xenopus tropicalis GN=nup93 PE=2 SV=1 PF04097 Nup93/Nic96 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1235 Predicted unusual protein kinase Cluster-8309.22819 BP_3 600.36 5.53 5527 270001895 EEZ98342.1 3071 0.0e+00 hypothetical protein TcasGA2_TC000797 [Tribolium castaneum] 194890784 XM_001977354.1 96 1.08298e-39 Drosophila erecta GG18278 (Dere\GG18278), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q13574 1713 3.4e-189 Diacylglycerol kinase zeta OS=Homo sapiens GN=DGKZ PE=1 SV=3 PF01757//PF07649//PF00628//PF16866//PF00781//PF00130//PF00609 Acyltransferase family//C1-like domain//PHD-finger//PHD-finger//Diacylglycerol kinase catalytic domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain GO:0055114//GO:0035556//GO:0046486//GO:0009395//GO:0007205 oxidation-reduction process//intracellular signal transduction//glycerolipid metabolic process//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway GO:0016301//GO:0016747//GO:0047134//GO:0004143//GO:0005515 kinase activity//transferase activity, transferring acyl groups other than amino-acyl groups//protein-disulfide reductase activity//diacylglycerol kinase activity//protein binding -- -- KOG0782 Predicted diacylglycerol kinase Cluster-8309.22822 BP_3 19.00 2.32 687 642912924 XP_008201308.1 247 1.0e-18 PREDICTED: eye-specific diacylglycerol kinase isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22823 BP_3 146.88 0.81 9051 642912924 XP_008201308.1 4062 0.0e+00 PREDICTED: eye-specific diacylglycerol kinase isoform X3 [Tribolium castaneum] 194890784 XM_001977354.1 96 1.77726e-39 Drosophila erecta GG18278 (Dere\GG18278), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q09103 1946 5.4e-216 Eye-specific diacylglycerol kinase OS=Drosophila melanogaster GN=rdgA PE=2 SV=2 PF00781//PF00609//PF00130//PF00628//PF13606//PF16866//PF00023 Diacylglycerol kinase catalytic domain//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//Ankyrin repeat//PHD-finger//Ankyrin repeat GO:0007205//GO:0009395//GO:0035556//GO:0046486 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//intracellular signal transduction//glycerolipid metabolic process GO:0004143//GO:0016301//GO:0005515 diacylglycerol kinase activity//kinase activity//protein binding -- -- KOG0782 Predicted diacylglycerol kinase Cluster-8309.22825 BP_3 214.50 1.37 7847 189234316 XP_972412.2 4154 0.0e+00 PREDICTED: eye-specific diacylglycerol kinase isoform X1 [Tribolium castaneum] 808145633 XM_012318648.1 294 1.31792e-149 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q13574 1713 4.9e-189 Diacylglycerol kinase zeta OS=Homo sapiens GN=DGKZ PE=1 SV=3 PF00609//PF00130//PF00781//PF03985//PF16866//PF01757//PF00628 Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase catalytic domain//Paf1//PHD-finger//Acyltransferase family//PHD-finger GO:0046486//GO:0035556//GO:0016570//GO:0006368//GO:0007205//GO:0009395 glycerolipid metabolic process//intracellular signal transduction//histone modification//transcription elongation from RNA polymerase II promoter//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process GO:0016747//GO:0016301//GO:0005515//GO:0004143 transferase activity, transferring acyl groups other than amino-acyl groups//kinase activity//protein binding//diacylglycerol kinase activity GO:0016593 Cdc73/Paf1 complex KOG0782 Predicted diacylglycerol kinase Cluster-8309.22826 BP_3 132.41 0.75 8824 646711260 KDR16495.1 346 4.3e-29 hypothetical protein L798_08583 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P34258 210 1.1e-14 Uncharacterized protein B0303.7 OS=Caenorhabditis elegans GN=B0303.7 PE=1 SV=5 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4225 Sorbin and SH3 domain-containing protein Cluster-8309.22827 BP_3 255.55 1.47 8653 642912924 XP_008201308.1 4047 0.0e+00 PREDICTED: eye-specific diacylglycerol kinase isoform X3 [Tribolium castaneum] 194890784 XM_001977354.1 96 1.69878e-39 Drosophila erecta GG18278 (Dere\GG18278), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q09103 1946 5.2e-216 Eye-specific diacylglycerol kinase OS=Drosophila melanogaster GN=rdgA PE=2 SV=2 PF00781//PF00130//PF00609//PF00023//PF00628//PF16866//PF13606 Diacylglycerol kinase catalytic domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//Ankyrin repeat//PHD-finger//PHD-finger//Ankyrin repeat GO:0007205//GO:0009395//GO:0046486//GO:0035556 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process//intracellular signal transduction GO:0016301//GO:0004143//GO:0005515 kinase activity//diacylglycerol kinase activity//protein binding -- -- KOG0782 Predicted diacylglycerol kinase Cluster-8309.22828 BP_3 241.40 10.09 1445 91093365 XP_969666.1 1939 1.4e-214 PREDICTED: nedd8-activating enzyme E1 catalytic subunit [Tribolium castaneum]>gi|270015296|gb|EFA11744.1| hypothetical protein TcasGA2_TC004234 [Tribolium castaneum] -- -- -- -- -- K10686 UBE1C, UBA3 ubiquitin-activating enzyme E1 C http://www.genome.jp/dbget-bin/www_bget?ko:K10686 Q7ZVX6 1606 2.3e-177 NEDD8-activating enzyme E1 catalytic subunit OS=Danio rerio GN=uba3 PE=2 SV=1 PF08825//PF00070//PF00899 E2 binding domain//Pyridine nucleotide-disulphide oxidoreductase//ThiF family GO:0055114//GO:0045116 oxidation-reduction process//protein neddylation GO:0008641//GO:0016491//GO:0005524//GO:0016881 small protein activating enzyme activity//oxidoreductase activity//ATP binding//acid-amino acid ligase activity -- -- KOG2015 NEDD8-activating complex, catalytic component UBA3 Cluster-8309.2283 BP_3 283.22 45.76 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22830 BP_3 355.68 3.89 4696 91086797 XP_973406.1 1419 8.8e-154 PREDICTED: CTD small phosphatase-like protein 2 [Tribolium castaneum]>gi|270009707|gb|EFA06155.1| hypothetical protein TcasGA2_TC009000 [Tribolium castaneum] 642929007 XM_008197430.1 42 9.58935e-10 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 8 (LOC662164), mRNA K17616 CTDSPL2 CTD small phosphatase-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17616 Q08BB5 687 2.7e-70 CTD small phosphatase-like protein 2-A OS=Danio rerio GN=ctdspl2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.22831 BP_3 234.45 1.73 6805 642915750 XP_008190789.1 4165 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.93718e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.8e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.22833 BP_3 238.01 2.05 5877 270015587 EFA12035.1 2530 1.6e-282 hypothetical protein TcasGA2_TC001452 [Tribolium castaneum] 642927958 XR_511541.1 53 9.22623e-16 PREDICTED: Tribolium castaneum transcriptional adapter 2B (LOC663682), transcript variant X2, misc_RNA K11673 ACTR8, ARP8, INO80N actin-related protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11673 Q0IEG8 1666 1.0e-183 Actin-related protein 8 OS=Aedes aegypti GN=Arp8 PE=3 SV=1 PF00569//PF06723//PF04433 Zinc finger, ZZ type//MreB/Mbl protein//SWIRM domain GO:0000902 cell morphogenesis GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0797 Actin-related protein Cluster-8309.22834 BP_3 17.92 0.58 1772 642918409 XP_008191460.1 1343 2.1e-145 PREDICTED: apterous isoform X1 [Tribolium castaneum] 641661021 XM_008183490.1 79 9.66391e-31 PREDICTED: Acyrthosiphon pisum LIM/homeobox protein Lhx2-like (LOC100165973), transcript variant X2, mRNA K09373 LHX2_9 LIM homeobox protein 2/9 http://www.genome.jp/dbget-bin/www_bget?ko:K09373 A2I8Z7 821 3.0e-86 LIM/homeobox protein Lhx9 OS=Astyanax fasciatus GN=lhx9 PE=2 SV=1 PF00046//PF05920//PF00412 Homeobox domain//Homeobox KN domain//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.22835 BP_3 18.57 0.74 1499 189235224 XP_967725.2 1833 2.8e-202 PREDICTED: coatomer subunit delta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 1294 3.6e-141 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.22837 BP_3 4041.00 51.18 4097 642928834 XP_008195581.1 744 1.4e-75 PREDICTED: proteoglycan 4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01484//PF06286 Nematode cuticle collagen N-terminal domain//Coleoptericin GO:0042742 defense response to bacterium GO:0042302 structural constituent of cuticle GO:0005576 extracellular region -- -- Cluster-8309.22839 BP_3 428.99 9.41 2489 91084135 XP_967479.1 1350 4.6e-146 PREDICTED: porphobilinogen deaminase [Tribolium castaneum]>gi|270006650|gb|EFA03098.1| hypothetical protein TcasGA2_TC013007 [Tribolium castaneum] -- -- -- -- -- K01749 hemC, HMBS hydroxymethylbilane synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01749 Q2KIN5 699 5.9e-72 Porphobilinogen deaminase OS=Bos taurus GN=HMBS PE=2 SV=1 PF01379//PF03900 Porphobilinogen deaminase, dipyromethane cofactor binding domain//Porphobilinogen deaminase, C-terminal domain GO:0044237//GO:0033014//GO:0015994//GO:0071704 cellular metabolic process//tetrapyrrole biosynthetic process//chlorophyll metabolic process//organic substance metabolic process GO:0004418 hydroxymethylbilane synthase activity -- -- KOG2892 Porphobilinogen deaminase Cluster-8309.2284 BP_3 180.78 28.08 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22840 BP_3 403.01 8.55 2563 91084135 XP_967479.1 1187 3.8e-127 PREDICTED: porphobilinogen deaminase [Tribolium castaneum]>gi|270006650|gb|EFA03098.1| hypothetical protein TcasGA2_TC013007 [Tribolium castaneum] -- -- -- -- -- K01749 hemC, HMBS hydroxymethylbilane synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01749 P22907 797 2.6e-83 Porphobilinogen deaminase OS=Mus musculus GN=Hmbs PE=1 SV=2 PF03900//PF01379 Porphobilinogen deaminase, C-terminal domain//Porphobilinogen deaminase, dipyromethane cofactor binding domain GO:0018160//GO:0015994//GO:0033014 peptidyl-pyrromethane cofactor linkage//chlorophyll metabolic process//tetrapyrrole biosynthetic process GO:0004418 hydroxymethylbilane synthase activity -- -- KOG2892 Porphobilinogen deaminase Cluster-8309.22843 BP_3 117.31 0.94 6337 642912779 XP_008201247.1 3750 0.0e+00 PREDICTED: chaoptin isoform X1 [Tribolium castaneum] 759065584 XM_011343927.1 47 2.15339e-12 PREDICTED: Cerapachys biroi homeobox protein Hox-B1a-like (LOC105282160), mRNA -- -- -- -- P12024 2695 5.3e-303 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF13855//PF00046//PF00560 Leucine rich repeat//Homeobox domain//Leucine Rich Repeat -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22845 BP_3 1.66 0.32 541 270006733 EFA03181.1 151 1.1e-07 hypothetical protein TcasGA2_TC013101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22846 BP_3 26.72 0.42 3345 556993813 XP_006001025.1 197 3.1e-12 PREDICTED: zinc finger protein 729-like [Latimeria chalumnae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5T619 185 3.2e-12 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1 PF13465//PF00096//PF01155//PF07975//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TFIIH C1-like domain//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006281//GO:0006464 DNA repair//cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.22847 BP_3 9.00 1.29 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2285 BP_3 80.00 99.82 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22851 BP_3 54.00 2.70 1256 852808191 XP_012892241.1 180 1.1e-10 PREDICTED: zinc finger protein 180-like [Dipodomys ordii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86UE3 168 1.1e-10 Zinc finger protein 546 OS=Homo sapiens GN=ZNF546 PE=2 SV=2 PF07776//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.22852 BP_3 239.12 2.76 4462 612027528 XP_007492659.1 655 3.2e-65 PREDICTED: zinc finger protein 850-like isoform X1 [Monodelphis domestica]>gi|612027530|ref|XP_007492660.1| PREDICTED: zinc finger protein 850-like isoform X2 [Monodelphis domestica] 821006972 XM_012511054.1 37 5.4815e-07 PREDICTED: Nomascus leucogenys zinc finger and SCAN domain containing 20 (ZSCAN20), transcript variant X2, mRNA -- -- -- -- Q9BX82 634 3.6e-64 Zinc finger protein 471 OS=Homo sapiens GN=ZNF471 PE=2 SV=1 PF00498//PF03368//PF00130//PF00096//PF00320//PF16622//PF13912//PF13465 FHA domain//Dicer dimerisation domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//GATA zinc finger//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain GO:0051252//GO:0035556//GO:0006355 regulation of RNA metabolic process//intracellular signal transduction//regulation of transcription, DNA-templated GO:0046872//GO:0003700//GO:0016891//GO:0008270//GO:0043565//GO:0005515 metal ion binding//transcription factor activity, sequence-specific DNA binding//endoribonuclease activity, producing 5'-phosphomonoesters//zinc ion binding//sequence-specific DNA binding//protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.22853 BP_3 14.76 0.56 1572 850302891 XP_012861832.1 644 2.2e-64 PREDICTED: zinc finger protein 420-like [Echinops telfairi] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 B4DU55 626 1.1e-63 Zinc finger protein 879 OS=Homo sapiens GN=ZNF879 PE=2 SV=2 PF00096//PF13465//PF01428//PF02892//PF01363//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//AN1-like Zinc finger//BED zinc finger//FYVE zinc finger//C2H2-type zinc finger -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.22854 BP_3 256.46 40.49 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22856 BP_3 90.00 2.09 2370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22857 BP_3 34.00 1.27 1580 270003816 EFA00264.1 417 4.5e-38 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] 805821658 XM_012295481.1 60 3.13562e-20 PREDICTED: Megachile rotundata zinc finger protein OZF-like (LOC105663827), mRNA -- -- -- -- Q7KQZ4 263 1.3e-21 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF02176//PF00096//PF01155 Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0008270//GO:0046872//GO:0016151 zinc ion binding//metal ion binding//nickel cation binding -- -- -- -- Cluster-8309.22859 BP_3 24.00 2.55 745 91082383 XP_968748.1 213 9.6e-15 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 160 5.6e-10 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.2286 BP_3 30.95 1.03 1741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22860 BP_3 40.67 1.83 1365 751224154 XP_011165403.1 664 9.0e-67 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22861 BP_3 359.00 6.37 3010 642912013 XP_008199060.1 659 7.5e-66 PREDICTED: uncharacterized protein LOC103314519 [Tribolium castaneum]>gi|270015103|gb|EFA11551.1| branchless [Tribolium castaneum] -- -- -- -- -- K04358 FGF fibroblast growth factor http://www.genome.jp/dbget-bin/www_bget?ko:K04358 P41444 277 6.1e-23 Fibroblast growth factor homolog OS=Autographa californica nuclear polyhedrosis virus GN=FGF PE=3 SV=1 PF15234//PF00167 Linker for activation of T-cells//Fibroblast growth factor GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.22865 BP_3 11.00 0.38 1675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22867 BP_3 121.61 1.63 3887 478256717 ENN76898.1 281 6.6e-22 hypothetical protein YQE_06546, partial [Dendroctonus ponderosae]>gi|478266402|gb|ENN82785.1| hypothetical protein YQE_00848, partial [Dendroctonus ponderosae]>gi|546681300|gb|ERL91414.1| hypothetical protein D910_08746 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22869 BP_3 193.81 2.76 3678 478254444 ENN74696.1 1939 3.5e-214 hypothetical protein YQE_08813, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XIL5 988 2.7e-105 Beta-galactosidase-1-like protein 3 OS=Rattus norvegicus GN=Glb1l3 PE=2 SV=1 PF13855//PF00150//PF00560//PF02449 Leucine rich repeat//Cellulase (glycosyl hydrolase family 5)//Leucine Rich Repeat//Beta-galactosidase GO:0006027//GO:0006012//GO:0006687//GO:0046486//GO:0005975 glycosaminoglycan catabolic process//galactose metabolic process//glycosphingolipid metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0005515//GO:0004553//GO:0004565 protein binding//hydrolase activity, hydrolyzing O-glycosyl compounds//beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.2287 BP_3 826.42 56.80 993 478258228 ENN78357.1 137 8.4e-06 hypothetical protein YQE_05159, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22870 BP_3 56.92 1.27 2445 642939462 XP_008200412.1 1546 8.6e-169 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [Tribolium castaneum]>gi|270016524|gb|EFA12970.1| immune response deficient 5 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 666 3.9e-68 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.22873 BP_3 120.17 3.27 2065 167234445 NP_001107837.1 1320 1.2e-142 hedgehog precursor [Tribolium castaneum] -- -- -- -- -- K11988 SHH sonic hedgehog http://www.genome.jp/dbget-bin/www_bget?ko:K11988 Q90419 922 6.8e-98 Tiggy-winkle hedgehog protein OS=Danio rerio GN=shhb PE=1 SV=1 PF01079//PF01085//PF05203 Hint module//Hedgehog amino-terminal signalling domain//Hom_end-associated Hint GO:0006508//GO:0030908//GO:0007267 proteolysis//protein splicing//cell-cell signaling GO:0008233 peptidase activity -- -- KOG3638 Sonic hedgehog and related proteins Cluster-8309.22874 BP_3 7.00 0.88 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22875 BP_3 57.70 0.80 3749 642927147 XP_008195157.1 2824 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35859 372 7.3e-34 Insulin-like growth factor-binding protein complex acid labile subunit OS=Rattus norvegicus GN=Igfals PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22876 BP_3 3777.30 51.50 3827 642927147 XP_008195157.1 3834 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12024 425 5.3e-40 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22878 BP_3 50.69 0.65 4046 642910868 XP_008193440.1 3019 0.0e+00 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1045 7.2e-112 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF00103//PF08123//PF02390 Somatotropin hormone family//Histone methylation protein DOT1//Putative methyltransferase GO:0007165//GO:0009451//GO:0006479//GO:0008033//GO:0006554//GO:0006400 signal transduction//RNA modification//protein methylation//tRNA processing//lysine catabolic process//tRNA modification GO:0018024//GO:0005179//GO:0008176 histone-lysine N-methyltransferase activity//hormone activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.22883 BP_3 6.00 0.32 1207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22884 BP_3 20.00 1.08 1185 642935340 XP_968306.2 543 8.4e-53 PREDICTED: kelch domain-containing protein 10 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZB86 344 4.1e-31 Kelch domain-containing protein 10 homolog OS=Drosophila melanogaster GN=slim PE=1 SV=1 PF01344//PF09187//PF07646 Kelch motif//Domain of unknown function(DUF1950)//Kelch motif GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.22888 BP_3 4.36 0.32 956 332375110 AEE62696.1 432 5.0e-40 unknown [Dendroctonus ponderosae]>gi|478257862|gb|ENN78004.1| hypothetical protein YQE_05524, partial [Dendroctonus ponderosae]>gi|546674573|gb|ERL85926.1| hypothetical protein D910_03341 [Dendroctonus ponderosae] -- -- -- -- -- K08211 SLC22A15 MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 15 http://www.genome.jp/dbget-bin/www_bget?ko:K08211 Q9VCA2 231 4.2e-18 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690//PF05830 Sugar (and other) transporter//Major Facilitator Superfamily//Nodulation protein Z (NodZ) GO:0009877//GO:0055085//GO:0009312 nodulation//transmembrane transport//oligosaccharide biosynthetic process GO:0016758//GO:0022857 transferase activity, transferring hexosyl groups//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.22889 BP_3 32.63 0.54 3199 91079722 XP_969695.1 1629 2.7e-178 PREDICTED: xenotropic and polytropic retrovirus receptor 1 [Tribolium castaneum]>gi|270003331|gb|EEZ99778.1| hypothetical protein TcasGA2_TC002557 [Tribolium castaneum] 827561892 XM_004932993.2 53 4.99616e-16 PREDICTED: Bombyx mori xenotropic and polytropic retrovirus receptor 1 (LOC101739894), mRNA -- -- -- -- Q9QZ70 1093 1.6e-117 Xenotropic and polytropic retrovirus receptor 1 homolog OS=Cricetulus griseus GN=XPR1 PE=2 SV=1 PF03124 EXS family -- -- -- -- GO:0016021 integral component of membrane KOG1162 Predicted small molecule transporter Cluster-8309.2289 BP_3 25.00 1.36 1178 307190333 EFN74406.1 720 2.5e-73 hypothetical protein EAG_08095, partial [Camponotus floridanus] 462334478 APGK01038567.1 51 2.33622e-15 Dendroctonus ponderosae Seq01038577, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF09360//PF00703 Iron-binding zinc finger CDGSH type//Glycosyl hydrolases family 2 GO:0005975 carbohydrate metabolic process GO:0051537//GO:0004553 2 iron, 2 sulfur cluster binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.22891 BP_3 1112.20 14.29 4043 270297188 NP_001161909.1 1041 5.1e-110 cuticular protein analogous to peritrophins 3-A2 precursor [Tribolium castaneum]>gi|268309020|gb|ACY95476.1| cuticular protein analogous to peritrophins 3-A2 [Tribolium castaneum]>gi|270000883|gb|EEZ97330.1| hypothetical protein TcasGA2_TC011141 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76217 139 8.2e-07 Peritrophin-1 OS=Anopheles gambiae GN=Aper1 PE=2 SV=2 PF01607//PF06941 Chitin binding Peritrophin-A domain//5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) GO:0006030//GO:0009264 chitin metabolic process//deoxyribonucleotide catabolic process GO:0008253//GO:0008061 5'-nucleotidase activity//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.22892 BP_3 68.00 3.55 1216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22893 BP_3 149.00 3.03 2659 478255299 ENN75525.1 179 3.0e-10 hypothetical protein YQE_07868, partial [Dendroctonus ponderosae]>gi|546683147|gb|ERL92998.1| hypothetical protein D910_10301 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22894 BP_3 136.10 1.25 5524 270016478 EFA12924.1 1944 1.4e-214 hypothetical protein TcasGA2_TC006994 [Tribolium castaneum] 827555134 XM_012693612.1 128 1.76068e-57 PREDICTED: Bombyx mori USP6 N-terminal-like protein (LOC101746723), mRNA -- -- -- -- Q80XC3 1096 1.2e-117 USP6 N-terminal-like protein OS=Mus musculus GN=Usp6nl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.22895 BP_3 92.60 0.85 5514 270016478 EFA12924.1 1944 1.4e-214 hypothetical protein TcasGA2_TC006994 [Tribolium castaneum] 827555134 XM_012693612.1 128 1.75747e-57 PREDICTED: Bombyx mori USP6 N-terminal-like protein (LOC101746723), mRNA -- -- -- -- Q80XC3 1096 1.2e-117 USP6 N-terminal-like protein OS=Mus musculus GN=Usp6nl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.22897 BP_3 595.08 20.15 1715 91087901 XP_970608.1 1202 4.6e-129 PREDICTED: protein cereblon [Tribolium castaneum]>gi|270012017|gb|EFA08465.1| hypothetical protein TcasGA2_TC006114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CF65 547 1.7e-54 Protein cereblon OS=Gallus gallus GN=CRBN PE=1 SV=1 PF02190 ATP-dependent protease La (LON) substrate-binding domain GO:0006508//GO:0006510 proteolysis//obsolete ATP-dependent proteolysis GO:0004176 ATP-dependent peptidase activity -- -- KOG1400 Predicted ATP-dependent protease PIL, contains LON domain Cluster-8309.22905 BP_3 5.00 1.33 472 641647755 XP_008179502.1 146 3.6e-07 PREDICTED: uncharacterized protein LOC103308224 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22906 BP_3 1.00 3.30 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22907 BP_3 28.24 0.46 3280 642912029 XP_008199066.1 1820 1.9e-200 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 375 2.9e-34 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF02460//PF00873 Patched family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.22908 BP_3 12.11 0.37 1866 189237225 XP_001810464.1 625 4.1e-62 PREDICTED: inhibitor of growth protein 5 isoform X3 [Tribolium castaneum] 170041067 XM_001848247.1 126 7.60125e-57 Culex quinquefasciatus inhibitor of growth protein, ing4, mRNA K11346 ING4 inhibitor of growth protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11346 Q5ZKY4 378 7.4e-35 Inhibitor of growth protein 4 OS=Gallus gallus GN=ING4 PE=2 SV=1 PF00628//PF06320//PF00103 PHD-finger//GCN5-like protein 1 (GCN5L1)//Somatotropin hormone family GO:0007165 signal transduction GO:0005179//GO:0005515 hormone activity//protein binding GO:0005576//GO:0031083 extracellular region//BLOC-1 complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.22909 BP_3 172.84 1.46 5997 91088115 XP_969791.1 1930 6.2e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.9e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF04851//PF01105 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//emp24/gp25L/p24 family/GOLD GO:0006810 transport GO:0008026//GO:0003676//GO:0016787//GO:0003677//GO:0005524 ATP-dependent helicase activity//nucleic acid binding//hydrolase activity//DNA binding//ATP binding GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.22910 BP_3 12.27 0.41 1723 91087821 XP_966824.1 1091 3.5e-116 PREDICTED: two pore potassium channel protein sup-9 [Tribolium castaneum]>gi|270011967|gb|EFA08415.1| hypothetical protein TcasGA2_TC006062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 210 2.1e-15 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF08586//PF00520//PF01007 RSC complex, Rsc14/Ldb7 subunit//Ion transport protein//Inward rectifier potassium channel GO:0006811//GO:0055085//GO:0043044//GO:0006813//GO:0006810 ion transport//transmembrane transport//ATP-dependent chromatin remodeling//potassium ion transport//transport GO:0005216//GO:0005242 ion channel activity//inward rectifier potassium channel activity GO:0016020//GO:0008076//GO:0016021//GO:0016586 membrane//voltage-gated potassium channel complex//integral component of membrane//RSC complex -- -- Cluster-8309.22911 BP_3 46.73 1.52 1775 91087821 XP_966824.1 1091 3.6e-116 PREDICTED: two pore potassium channel protein sup-9 [Tribolium castaneum]>gi|270011967|gb|EFA08415.1| hypothetical protein TcasGA2_TC006062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 210 2.1e-15 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF00520//PF08586//PF01007 Ion transport protein//RSC complex, Rsc14/Ldb7 subunit//Inward rectifier potassium channel GO:0006811//GO:0043044//GO:0006813//GO:0006810//GO:0055085 ion transport//ATP-dependent chromatin remodeling//potassium ion transport//transport//transmembrane transport GO:0005216//GO:0005242 ion channel activity//inward rectifier potassium channel activity GO:0008076//GO:0016020//GO:0016021//GO:0016586 voltage-gated potassium channel complex//membrane//integral component of membrane//RSC complex -- -- Cluster-8309.22913 BP_3 4.44 0.31 985 546683068 ERL92929.1 526 6.5e-51 hypothetical protein D910_10234 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7Z2K6 255 7.1e-21 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.22915 BP_3 149.00 9.97 1012 642929480 XP_008195856.1 759 6.4e-78 PREDICTED: HD domain-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642929482|ref|XP_008195857.1| PREDICTED: HD domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07023 K07023 putative hydrolases of HD superfamily http://www.genome.jp/dbget-bin/www_bget?ko:K07023 Q7Z4H3 423 2.4e-40 HD domain-containing protein 2 OS=Homo sapiens GN=HDDC2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3197 Predicted hydrolases of HD superfamily Cluster-8309.22919 BP_3 91.43 1.55 3128 642915391 XP_008190597.1 403 3.8e-36 PREDICTED: cytochrome c oxidase subunit 6B2 isoform X1 [Tribolium castaneum] 642915392 XM_969527.2 84 2.8574e-33 PREDICTED: Tribolium castaneum cytochrome c oxidase subunit 6B2 (LOC663486), transcript variant X2, mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 P14854 264 2.0e-21 Cytochrome c oxidase subunit 6B1 OS=Homo sapiens GN=COX6B1 PE=1 SV=2 PF02297//PF07393 Cytochrome oxidase c subunit VIb//Exocyst complex component Sec10 GO:0006123//GO:0048278//GO:0006887//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//vesicle docking//exocytosis//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005739//GO:0005737 respiratory chain complex IV//mitochondrion//cytoplasm KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.22920 BP_3 3.00 1.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF00537//PF10280 Arthropod defensin//Scorpion toxin-like domain//Mediator complex protein GO:0006357//GO:0006810//GO:0006952 regulation of transcription from RNA polymerase II promoter//transport//defense response GO:0001104//GO:0008200 RNA polymerase II transcription cofactor activity//ion channel inhibitor activity GO:0005576//GO:0016592 extracellular region//mediator complex -- -- Cluster-8309.22924 BP_3 30.10 2.46 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03694 Erg28 like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22925 BP_3 548.11 7.91 3631 642933999 XP_008197598.1 837 2.1e-86 PREDICTED: biorientation of chromosomes in cell division protein 1-like 1 [Tribolium castaneum]>gi|270013676|gb|EFA10124.1| hypothetical protein TcasGA2_TC012304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96IK1 368 2.1e-33 Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens GN=BOD1 PE=1 SV=2 PF08287 Spc19 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0005876//GO:0042729 spindle microtubule//DASH complex -- -- Cluster-8309.22928 BP_3 348.30 5.05 3613 642933999 XP_008197598.1 837 2.1e-86 PREDICTED: biorientation of chromosomes in cell division protein 1-like 1 [Tribolium castaneum]>gi|270013676|gb|EFA10124.1| hypothetical protein TcasGA2_TC012304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96IK1 368 2.1e-33 Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens GN=BOD1 PE=1 SV=2 PF08287 Spc19 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0005876//GO:0042729 spindle microtubule//DASH complex -- -- Cluster-8309.22930 BP_3 111.89 1.36 4247 91089441 XP_967682.1 2588 2.2e-289 PREDICTED: calpain-7 [Tribolium castaneum]>gi|642933281|ref|XP_008197356.1| PREDICTED: calpain-7 [Tribolium castaneum]>gi|270012563|gb|EFA09011.1| hypothetical protein TcasGA2_TC006719 [Tribolium castaneum] -- -- -- -- -- K08576 CAPN7 calpain-7 http://www.genome.jp/dbget-bin/www_bget?ko:K08576 Q9R1S8 1801 1.6e-199 Calpain-7 OS=Mus musculus GN=Capn7 PE=2 SV=1 PF00515//PF13414//PF00648//PF13176//PF16785 Tetratricopeptide repeat//TPR repeat//Calpain family cysteine protease//Tetratricopeptide repeat//Small metal-binding protein GO:0006508 proteolysis GO:0004198//GO:0005515//GO:0046872 calcium-dependent cysteine-type endopeptidase activity//protein binding//metal ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.22931 BP_3 742.11 9.24 4164 478256753 ENN76934.1 2980 0.0e+00 hypothetical protein YQE_06581, partial [Dendroctonus ponderosae]>gi|546679210|gb|ERL89704.1| hypothetical protein D910_07067 [Dendroctonus ponderosae] -- -- -- -- -- K08576 CAPN7 calpain-7 http://www.genome.jp/dbget-bin/www_bget?ko:K08576 Q9R1S8 2025 1.7e-225 Calpain-7 OS=Mus musculus GN=Capn7 PE=2 SV=1 PF00515//PF13414//PF00648//PF13176//PF16785 Tetratricopeptide repeat//TPR repeat//Calpain family cysteine protease//Tetratricopeptide repeat//Small metal-binding protein GO:0006508 proteolysis GO:0004198//GO:0005515//GO:0046872 calcium-dependent cysteine-type endopeptidase activity//protein binding//metal ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.22935 BP_3 45.45 0.40 5832 189241815 XP_971376.2 3784 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1079 1.2e-115 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF01608//PF00397//PF13180//PF00595 I/LWEQ domain//WW domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.22937 BP_3 40.66 1.03 2202 642912489 XP_008200886.1 1238 4.0e-133 PREDICTED: Fanconi anemia group I protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVI1 283 9.0e-24 Fanconi anemia group I protein OS=Homo sapiens GN=FANCI PE=1 SV=4 PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- KOG4553 Uncharacterized conserved protein Cluster-8309.22938 BP_3 710.71 8.31 4415 478251697 ENN72151.1 1254 1.1e-134 hypothetical protein YQE_11208, partial [Dendroctonus ponderosae]>gi|546680949|gb|ERL91123.1| hypothetical protein D910_08464 [Dendroctonus ponderosae] 817214294 XM_012427986.1 53 6.91691e-16 PREDICTED: Orussus abietinus F-box only protein 28 (LOC105701325), transcript variant X4, mRNA K10306 FBXO28 F-box protein 28 http://www.genome.jp/dbget-bin/www_bget?ko:K10306 Q2NL16 367 3.3e-33 F-box only protein 28 OS=Bos taurus GN=FBXO28 PE=2 SV=1 PF00646//PF15966//PF02601//PF13013//PF12937//PF01702 F-box domain//F-box//Exonuclease VII, large subunit//F-box-like domain//F-box-like//Queuine tRNA-ribosyltransferase GO:0008616//GO:0006308//GO:0006400 queuosine biosynthetic process//DNA catabolic process//tRNA modification GO:0008479//GO:0008855//GO:0005515 queuine tRNA-ribosyltransferase activity//exodeoxyribonuclease VII activity//protein binding GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.22941 BP_3 534.27 3.49 7674 91091886 XP_970165.1 4070 0.0e+00 PREDICTED: protein Daple [Tribolium castaneum]>gi|270001124|gb|EEZ97571.1| hypothetical protein TcasGA2_TC011433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P219 787 1.1e-81 Protein Daple OS=Homo sapiens GN=CCDC88C PE=1 SV=3 PF01112//PF13851//PF00170 Asparaginase//Growth-arrest specific micro-tubule binding//bZIP transcription factor GO:0006355//GO:0048870 regulation of transcription, DNA-templated//cell motility GO:0043565//GO:0016787//GO:0003700 sequence-specific DNA binding//hydrolase activity//transcription factor activity, sequence-specific DNA binding GO:0031514//GO:0005667 motile cilium//transcription factor complex KOG1592 Asparaginase Cluster-8309.22943 BP_3 466.00 3.06 7621 91091886 XP_970165.1 3210 0.0e+00 PREDICTED: protein Daple [Tribolium castaneum]>gi|270001124|gb|EEZ97571.1| hypothetical protein TcasGA2_TC011433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1G1 633 8.1e-64 Threonine aspartase 1 OS=Mus musculus GN=Tasp1 PE=2 SV=1 PF01112//PF13851//PF06005//PF01075//PF00170 Asparaginase//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//Glycosyltransferase family 9 (heptosyltransferase)//bZIP transcription factor GO:0008152//GO:0048870//GO:0006355//GO:0043093//GO:0000917 metabolic process//cell motility//regulation of transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly GO:0016757//GO:0016787//GO:0043565//GO:0003700 transferase activity, transferring glycosyl groups//hydrolase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0031514//GO:0005667//GO:0005737 motile cilium//transcription factor complex//cytoplasm KOG1592 Asparaginase Cluster-8309.22944 BP_3 45.75 0.51 4645 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.7252e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 2.0e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186//PF00278 Vacuolar sorting 38 and autophagy-related subunit 14//Pyridoxal-dependent decarboxylase, C-terminal sheet domain GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.22947 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22949 BP_3 38.00 11.69 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22953 BP_3 654.00 14.46 2472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22956 BP_3 423.42 5.63 3918 642911078 XP_008200566.1 2414 3.1e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 3.5e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF07808//PF01585//PF00641//PF13442//PF11648 RED-like protein N-terminal region//G-patch domain//Zn-finger in Ran binding protein and others//Cytochrome C oxidase, cbb3-type, subunit III//C-terminal domain of RIG-I GO:0006118 obsolete electron transport GO:0003676//GO:0009055//GO:0008270//GO:0000166//GO:0016817//GO:0020037 nucleic acid binding//electron carrier activity//zinc ion binding//nucleotide binding//hydrolase activity, acting on acid anhydrides//heme binding GO:0005622//GO:0005634 intracellular//nucleus KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.22958 BP_3 412.00 14.82 1632 332376645 AEE63462.1 1875 4.0e-207 unknown [Dendroctonus ponderosae]>gi|478255231|gb|ENN75460.1| hypothetical protein YQE_08010, partial [Dendroctonus ponderosae]>gi|546679675|gb|ERL90102.1| hypothetical protein D910_07456 [Dendroctonus ponderosae] -- -- -- -- -- K12844 PRPF31 U4/U6 small nuclear ribonucleoprotein PRP31 http://www.genome.jp/dbget-bin/www_bget?ko:K12844 Q8WWY3 1418 1.6e-155 U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens GN=PRPF31 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2574 mRNA splicing factor PRP31 Cluster-8309.2296 BP_3 51.00 2.72 1196 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08170 POPLD (NUC188) domain GO:0051252//GO:0008033//GO:0006396 regulation of RNA metabolic process//tRNA processing//RNA processing GO:0004526 ribonuclease P activity GO:0030677 ribonuclease P complex -- -- Cluster-8309.22963 BP_3 134.90 2.55 2838 751225380 XP_011166071.1 214 2.8e-14 PREDICTED: uncharacterized protein LOC105200296 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.22964 BP_3 9.52 0.40 1441 546684814 ERL94396.1 1115 4.8e-119 hypothetical protein D910_11675 [Dendroctonus ponderosae] -- -- -- -- -- K03678 RRP45, EXOSC9 exosome complex component RRP45 http://www.genome.jp/dbget-bin/www_bget?ko:K03678 Q4QR75 726 2.5e-75 Exosome complex component RRP45 OS=Rattus norvegicus GN=Exosc9 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.22965 BP_3 107.55 0.87 6217 91091178 XP_971714.1 1911 1.0e-210 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] 564254995 XM_006266415.1 37 7.65503e-07 PREDICTED: Alligator mississippiensis F-box protein 21 (FBXO21), mRNA K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q9EPL9 1219 7.4e-132 Peroxisomal acyl-coenzyme A oxidase 3 OS=Mus musculus GN=Acox3 PE=1 SV=2 PF02770//PF00441//PF12937//PF00646//PF01756//PF08755 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//F-box-like//F-box domain//Acyl-CoA oxidase//Hemimethylated DNA-binding protein YccV like GO:0006635//GO:0006637//GO:0055114//GO:0006631//GO:0006118 fatty acid beta-oxidation//acyl-CoA metabolic process//oxidation-reduction process//fatty acid metabolic process//obsolete electron transport GO:0005515//GO:0003677//GO:0003995//GO:0016627//GO:0003997 protein binding//DNA binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.22967 BP_3 4.03 3.76 336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22968 BP_3 4.00 1.41 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22969 BP_3 17.00 1.02 1098 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2297 BP_3 2.00 0.33 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22970 BP_3 6.00 2.81 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03334 Na+/H+ antiporter subunit GO:0015672//GO:0015992 monovalent inorganic cation transport//proton transport GO:0005451 monovalent cation:proton antiporter activity -- -- -- -- Cluster-8309.22972 BP_3 1.00 23.78 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22979 BP_3 119.03 1.24 4900 676425900 XP_009044451.1 383 1.2e-33 hypothetical protein LOTGIDRAFT_156185 [Lottia gigantea]>gi|556116290|gb|ESP04942.1| hypothetical protein LOTGIDRAFT_156185 [Lottia gigantea] -- -- -- -- -- -- -- -- -- Q9CXE0 370 1.6e-33 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF07776//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.22980 BP_3 85.32 1.94 2408 270005418 EFA01866.1 1232 2.2e-132 hypothetical protein TcasGA2_TC007471 [Tribolium castaneum] -- -- -- -- -- K11405 HDAC8 histone deacetylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11405 Q8VH37 824 1.8e-86 Histone deacetylase 8 OS=Mus musculus GN=Hdac8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.22981 BP_3 115.49 2.05 3006 546683595 ERL93390.1 1233 2.1e-132 hypothetical protein D910_10682 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22983 BP_3 19.53 1.11 1138 762146544 XP_011456572.1 224 7.8e-16 PREDICTED: uncharacterized protein LOC105348724 [Crassostrea gigas]>gi|405962723|gb|EKC28372.1| hypothetical protein CGI_10023755 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22986 BP_3 295.31 3.59 4258 91084345 XP_972963.1 1762 1.3e-193 PREDICTED: SH2B adapter protein 2 isoform X1 [Tribolium castaneum]>gi|270008825|gb|EFA05273.1| hypothetical protein TcasGA2_TC015430 [Tribolium castaneum] -- -- -- -- -- K12459 SH2B1_3 SH2B adaptor protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12459 Q9UQQ2 476 7.3e-46 SH2B adapter protein 3 OS=Homo sapiens GN=SH2B3 PE=1 SV=2 PF01395//PF08916//PF00583//PF13508 PBP/GOBP family//Phenylalanine zipper//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967//GO:0007165//GO:0035556 acyl-carrier-protein biosynthetic process//signal transduction//intracellular signal transduction GO:0005543//GO:0008080//GO:0005549//GO:0004871 phospholipid binding//N-acetyltransferase activity//odorant binding//signal transducer activity GO:0005622 intracellular -- -- Cluster-8309.2299 BP_3 1.00 0.36 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22990 BP_3 672.51 29.22 1401 91089019 XP_968547.1 309 1.3e-25 PREDICTED: mitogen-activated protein kinase kinase kinase 7 [Tribolium castaneum]>gi|270012716|gb|EFA09164.1| TGF-beta activated kinase 1 [Tribolium castaneum] -- -- -- -- -- K04427 MAP3K7, TAK1 mitogen-activated protein kinase kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04427 Q5RFL3 139 2.8e-07 Mitogen-activated protein kinase kinase kinase 7 OS=Pongo abelii GN=MAP3K7 PE=2 SV=1 PF13931 Kinesin-associated microtubule-binding GO:0016310 phosphorylation GO:0008017//GO:0004672 microtubule binding//protein kinase activity GO:0045298 tubulin complex -- -- Cluster-8309.22991 BP_3 82.34 4.72 1133 91089011 XP_968226.1 1028 4.6e-109 PREDICTED: nuclear RNA export factor 1 [Tribolium castaneum]>gi|270011540|gb|EFA07988.1| hypothetical protein TcasGA2_TC005575 [Tribolium castaneum] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q9U1H9 574 8.3e-58 Nuclear RNA export factor 1 OS=Drosophila melanogaster GN=sbr PE=1 SV=2 PF13855//PF09162 Leucine rich repeat//Tap, RNA-binding GO:0051028//GO:0006406 mRNA transport//mRNA export from nucleus GO:0005515//GO:0003723//GO:0097159//GO:1901363 protein binding//RNA binding//organic cyclic compound binding//heterocyclic compound binding GO:0005634//GO:0005737//GO:0044424 nucleus//cytoplasm//intracellular part KOG3763 mRNA export factor TAP/MEX67 Cluster-8309.22995 BP_3 83.00 6.98 865 332372907 AEE61595.1 376 1.4e-33 unknown [Dendroctonus ponderosae]>gi|478261028|gb|ENN80606.1| hypothetical protein YQE_02971, partial [Dendroctonus ponderosae] -- -- -- -- -- K02219 CKS1 cyclin-dependent kinase regulatory subunit CKS1 http://www.genome.jp/dbget-bin/www_bget?ko:K02219 Q0P5A5 303 1.7e-26 Cyclin-dependent kinases regulatory subunit 1 OS=Bos taurus GN=CKS1B PE=3 SV=1 PF01111 Cyclin-dependent kinase regulatory subunit GO:0007049//GO:0045859 cell cycle//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG3484 Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins Cluster-8309.22997 BP_3 24.65 0.45 2943 805765285 XP_012134962.1 832 6.4e-86 PREDICTED: peptidyl-prolyl cis-trans isomerase cyp11 isoform X2 [Megachile rotundata] 645259408 XM_008237125.1 62 4.55942e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 O55035 612 8.5e-62 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.22998 BP_3 28.00 0.95 1711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22999 BP_3 10.00 1.37 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2300 BP_3 1.00 5.73 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23001 BP_3 2.00 0.68 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23003 BP_3 95.16 1.42 3522 91089961 XP_973612.1 1106 1.3e-117 PREDICTED: beta-1,4-galactosyltransferase 7 [Tribolium castaneum]>gi|270013550|gb|EFA09998.1| hypothetical protein TcasGA2_TC012167 [Tribolium castaneum] -- -- -- -- -- K00733 B4GALT7 xylosylprotein 4-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00733 Q8R087 728 3.6e-75 Beta-1,4-galactosyltransferase 7 OS=Mus musculus GN=B4galt7 PE=2 SV=1 -- -- GO:0005975 carbohydrate metabolic process GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.23005 BP_3 6.63 0.44 1025 642929303 XP_008195780.1 581 2.8e-57 PREDICTED: neural cell adhesion molecule 2-like [Tribolium castaneum] 642929302 XM_008197558.1 134 1.46971e-61 PREDICTED: Tribolium castaneum neural cell adhesion molecule 2-like (LOC662052), mRNA -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23006 BP_3 126.20 2.93 2365 642914217 XP_008201594.1 1237 5.6e-133 PREDICTED: abl interactor 2-like [Tribolium castaneum]>gi|270001565|gb|EEZ98012.1| hypothetical protein TcasGA2_TC000412 [Tribolium castaneum] -- -- -- -- -- K05751 ABI2 abl interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05751 Q9NYB9 522 1.9e-51 Abl interactor 2 OS=Homo sapiens GN=ABI2 PE=1 SV=1 PF01110//PF14604//PF00018//PF01213//PF07815//PF00031 Ciliary neurotrophic factor//Variant SH3 domain//SH3 domain//Adenylate cyclase associated (CAP) N terminal//Abl-interactor HHR//Cystatin domain GO:0040007//GO:0007010 growth//cytoskeleton organization GO:0003779//GO:0004869//GO:0005515 actin binding//cysteine-type endopeptidase inhibitor activity//protein binding GO:0005737 cytoplasm KOG2546 Abl interactor ABI-1, contains SH3 domain Cluster-8309.23007 BP_3 3.35 1.15 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23010 BP_3 515.09 8.39 3250 642937140 XP_008198709.1 1559 3.5e-170 PREDICTED: MMS19 nucleotide excision repair protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BP36 629 1.0e-63 MMS19 nucleotide excision repair protein homolog OS=Bos taurus GN=MMS19 PE=2 SV=3 PF02985//PF17082//PF03274 HEAT repeat//Spindle Pole Component 29//Foamy virus BEL 1/2 protein GO:0045893//GO:0016032//GO:0030474 positive regulation of transcription, DNA-templated//viral process//spindle pole body duplication GO:0005200//GO:0005515 structural constituent of cytoskeleton//protein binding GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG1967 DNA repair/transcription protein Mms19 Cluster-8309.23012 BP_3 25.19 0.40 3336 642937140 XP_008198709.1 1534 2.9e-167 PREDICTED: MMS19 nucleotide excision repair protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BP36 627 1.8e-63 MMS19 nucleotide excision repair protein homolog OS=Bos taurus GN=MMS19 PE=2 SV=3 PF17082//PF03274//PF02985 Spindle Pole Component 29//Foamy virus BEL 1/2 protein//HEAT repeat GO:0030474//GO:0045893//GO:0016032 spindle pole body duplication//positive regulation of transcription, DNA-templated//viral process GO:0005515//GO:0005200 protein binding//structural constituent of cytoskeleton GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG1967 DNA repair/transcription protein Mms19 Cluster-8309.23016 BP_3 186.07 1.13 8224 91076250 XP_966964.1 1806 2.0e-198 PREDICTED: testican-2 [Tribolium castaneum] 642912114 XM_961871.3 78 1.6372e-29 PREDICTED: Tribolium castaneum testican-2 (LOC655329), mRNA -- -- -- -- Q9ER58 343 3.7e-30 Testican-2 OS=Mus musculus GN=Spock2 PE=2 SV=1 PF15009//PF16554//PF13833//PF10591//PF08527//PF07648//PF00036//PF00050 Transmembrane protein 173//Dimerisation domain of d-ornithine 4,5-aminomutase//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//Protein-arginine deiminase (PAD) middle domain//Kazal-type serine protease inhibitor domain//EF hand//Kazal-type serine protease inhibitor domain GO:0007165//GO:0018101//GO:0002218//GO:0006807//GO:0032481 signal transduction//protein citrullination//activation of innate immune response//nitrogen compound metabolic process//positive regulation of type I interferon production GO:0046983//GO:0005515//GO:0005509//GO:0004668 protein dimerization activity//protein binding//calcium ion binding//protein-arginine deiminase activity GO:0005578//GO:0005737 proteinaceous extracellular matrix//cytoplasm KOG3555 Ca2+-binding proteoglycan Testican Cluster-8309.23017 BP_3 917.18 4.50 10106 91076250 XP_966964.1 1806 2.5e-198 PREDICTED: testican-2 [Tribolium castaneum] 642912114 XM_961871.3 78 2.01356e-29 PREDICTED: Tribolium castaneum testican-2 (LOC655329), mRNA -- -- -- -- Q9ER58 343 4.6e-30 Testican-2 OS=Mus musculus GN=Spock2 PE=2 SV=1 PF00050//PF00036//PF07648//PF08527//PF16554//PF15009//PF13833//PF10591 Kazal-type serine protease inhibitor domain//EF hand//Kazal-type serine protease inhibitor domain//Protein-arginine deiminase (PAD) middle domain//Dimerisation domain of d-ornithine 4,5-aminomutase//Transmembrane protein 173//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region GO:0032481//GO:0006807//GO:0002218//GO:0018101//GO:0007165 positive regulation of type I interferon production//nitrogen compound metabolic process//activation of innate immune response//protein citrullination//signal transduction GO:0004668//GO:0005509//GO:0005515//GO:0046983 protein-arginine deiminase activity//calcium ion binding//protein binding//protein dimerization activity GO:0005737//GO:0005578 cytoplasm//proteinaceous extracellular matrix KOG3555 Ca2+-binding proteoglycan Testican Cluster-8309.23019 BP_3 18.00 0.64 1642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23021 BP_3 53.13 0.55 4955 91082383 XP_968748.1 3906 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2657 1.1e-298 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00910//PF00005//PF03193//PF03266//PF01637//PF00437//PF01580//PF00931//PF03205//PF06414//PF02367//PF01695//PF00664//PF01372//PF01926//PF13304 RNA helicase//ABC transporter//Protein of unknown function, DUF258//NTPase//Archaeal ATPase//Type II/IV secretion system protein//FtsK/SpoIIIE family//NB-ARC domain//Molybdopterin guanine dinucleotide synthesis protein B//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//IstB-like ATP binding protein//ABC transporter transmembrane region//Melittin//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0009987//GO:0006777//GO:0006810//GO:0055085//GO:0002949//GO:0045859 cellular process//Mo-molybdopterin cofactor biosynthetic process//transport//transmembrane transport//tRNA threonylcarbamoyladenosine modification//regulation of protein kinase activity GO:0042626//GO:0000166//GO:0016301//GO:0016887//GO:0003924//GO:0005524//GO:0098519//GO:0003724//GO:0005525//GO:0043531//GO:0003723//GO:0004860//GO:0003677 ATPase activity, coupled to transmembrane movement of substances//nucleotide binding//kinase activity//ATPase activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//RNA helicase activity//GTP binding//ADP binding//RNA binding//protein kinase inhibitor activity//DNA binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.23022 BP_3 6.65 0.39 1105 642937495 XP_008198863.1 197 1.0e-12 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23024 BP_3 26.34 0.44 3166 -- -- -- -- -- 301173032 NR_036303.1 37 3.87643e-07 Tribolium castaneum microRNA mir-277 (Mir277), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23027 BP_3 95.00 1.13 4356 270002498 EEZ98945.1 226 1.8e-15 hypothetical protein TcasGA2_TC004569 [Tribolium castaneum] 642912108 XM_008202587.1 94 1.10216e-38 PREDICTED: Tribolium castaneum V-type proton ATPase 116 kDa subunit a isoform 1 (LOC655096), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23028 BP_3 553.90 23.56 1425 546672777 ERL84533.1 903 1.8e-94 hypothetical protein D910_01963 [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q06AU5 721 9.4e-75 Ras-related protein Rab-32 OS=Sus scrofa GN=RAB32 PE=2 SV=1 PF08477//PF01926//PF00025//PF02367//PF00503//PF04670//PF00071//PF10662 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//G-protein alpha subunit//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation GO:0007264//GO:0007186//GO:0002949//GO:0007165//GO:0006576 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification//signal transduction//cellular biogenic amine metabolic process GO:0005525//GO:0019001//GO:0004871//GO:0003924//GO:0005524//GO:0031683 GTP binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding -- -- -- -- Cluster-8309.23030 BP_3 427.31 6.65 3387 817061123 XP_012252151.1 255 5.9e-19 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23031 BP_3 9.34 0.65 989 91085433 XP_968535.1 502 4.0e-48 PREDICTED: histone chaperone asf1 [Tribolium castaneum]>gi|270009165|gb|EFA05613.1| hypothetical protein TcasGA2_TC015819 [Tribolium castaneum] 617593976 XM_007521288.1 73 1.15047e-27 PREDICTED: Erinaceus europaeus anti-silencing function 1A histone chaperone (ASF1A), mRNA K10753 ASF1 histone chaperone ASF1 http://www.genome.jp/dbget-bin/www_bget?ko:K10753 Q9V464 371 2.5e-34 Histone chaperone asf1 OS=Drosophila melanogaster GN=asf1 PE=1 SV=1 PF04729 ASF1 like histone chaperone GO:0006333 chromatin assembly or disassembly -- -- GO:0005634 nucleus KOG3265 Histone chaperone involved in gene silencing Cluster-8309.23033 BP_3 9.86 0.33 1735 91092806 XP_967025.1 1106 6.4e-118 PREDICTED: protein henna [Tribolium castaneum]>gi|270003060|gb|EEZ99507.1| hypothetical protein TcasGA2_TC000087 [Tribolium castaneum] -- -- -- -- -- K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 799 1.0e-83 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF01842//PF00351 ACT domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0009094//GO:0006559//GO:0055114//GO:0006571//GO:0000162//GO:0008152 L-phenylalanine biosynthetic process//L-phenylalanine catabolic process//oxidation-reduction process//tyrosine biosynthetic process//tryptophan biosynthetic process//metabolic process GO:0016597//GO:0004505//GO:0005506//GO:0016714 amino acid binding//phenylalanine 4-monooxygenase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.23034 BP_3 11.60 0.60 1227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23036 BP_3 83.80 1.39 3199 642912647 XP_008200948.1 296 9.9e-24 PREDICTED: CREB/ATF bZIP transcription factor-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01253//PF05791//PF01166//PF00170//PF07716 Translation initiation factor SUI1//Bacillus haemolytic enterotoxin (HBL)//TSC-22/dip/bun family//bZIP transcription factor//Basic region leucine zipper GO:0006355//GO:0006413//GO:0006446//GO:0009405 regulation of transcription, DNA-templated//translational initiation//regulation of translational initiation//pathogenesis GO:0003700//GO:0043565//GO:0003743 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//translation initiation factor activity GO:0005840//GO:0016020//GO:0005667 ribosome//membrane//transcription factor complex -- -- Cluster-8309.23037 BP_3 3.00 0.57 546 478252250 ENN72678.1 171 5.2e-10 hypothetical protein YQE_10776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23038 BP_3 3.00 2.16 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23040 BP_3 29.93 1.13 1564 780616929 XP_011698547.1 251 8.0e-19 PREDICTED: zinc finger BED domain-containing protein RICESLEEPER 2-like [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23042 BP_3 114.69 2.06 2969 478250852 ENN71341.1 1034 2.4e-109 hypothetical protein YQE_11956, partial [Dendroctonus ponderosae]>gi|546678340|gb|ERL88982.1| hypothetical protein D910_06360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VPK7 587 6.8e-59 Putative tRNA pseudouridine synthase Pus10 OS=Drosophila melanogaster GN=Pus10 PE=2 SV=2 PF02058//PF01416 Guanylin precursor//tRNA pseudouridine synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0030250//GO:0009982//GO:0003723 guanylate cyclase activator activity//pseudouridine synthase activity//RNA binding GO:0005576 extracellular region KOG2364 Predicted pseudouridylate synthase Cluster-8309.23044 BP_3 42.70 0.88 2638 91085293 XP_968143.1 1111 2.5e-118 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 Q3SZA5 642 2.5e-65 Spermine synthase OS=Bos taurus GN=SMS PE=2 SV=1 PF00891//PF03602//PF05175//PF01728//PF08241//PF02390 O-methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain//FtsJ-like methyltransferase//Methyltransferase domain//Putative methyltransferase GO:0009451//GO:0008033//GO:0006597//GO:0019482//GO:0032259//GO:0006400//GO:0008152//GO:0006525//GO:0031167//GO:0006560 RNA modification//tRNA processing//spermine biosynthetic process//beta-alanine metabolic process//methylation//tRNA modification//metabolic process//arginine metabolic process//rRNA methylation//proline metabolic process GO:0016768//GO:0008176//GO:0008168//GO:0008171 spermine synthase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//O-methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.23045 BP_3 523.00 13.28 2190 642914217 XP_008201594.1 1784 1.9e-196 PREDICTED: abl interactor 2-like [Tribolium castaneum]>gi|270001565|gb|EEZ98012.1| hypothetical protein TcasGA2_TC000412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NYB9 522 1.7e-51 Abl interactor 2 OS=Homo sapiens GN=ABI2 PE=1 SV=1 PF00031//PF07815//PF01110//PF14604//PF00018 Cystatin domain//Abl-interactor HHR//Ciliary neurotrophic factor//Variant SH3 domain//SH3 domain GO:0040007 growth GO:0004869//GO:0005515 cysteine-type endopeptidase inhibitor activity//protein binding GO:0005737 cytoplasm KOG2546 Abl interactor ABI-1, contains SH3 domain Cluster-8309.23046 BP_3 89.31 1.71 2809 91081805 XP_974174.1 967 1.4e-101 PREDICTED: equilibrative nucleoside transporter 3 [Tribolium castaneum]>gi|270006294|gb|EFA02742.1| hypothetical protein TcasGA2_TC008473 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q99808 372 5.5e-34 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF07690//PF01733 Major Facilitator Superfamily//Nucleoside transporter GO:0055085//GO:0015858//GO:0006810 transmembrane transport//nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.2305 BP_3 43.00 1.39 1785 478261332 ENN80746.1 950 8.0e-100 hypothetical protein YQE_02832, partial [Dendroctonus ponderosae]>gi|546675333|gb|ERL86550.1| hypothetical protein D910_03957 [Dendroctonus ponderosae] 530612397 XM_005297731.1 91 2.07791e-37 PREDICTED: Chrysemys picta bellii forkhead box B2 (FOXB2), mRNA K09411 FOXX forkhead box protein, other http://www.genome.jp/dbget-bin/www_bget?ko:K09411 P32028 647 4.5e-66 Fork head domain-containing protein FD4 OS=Drosophila melanogaster GN=fd96Ca PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG3562 Forkhead/HNF-3-related transcription factor Cluster-8309.23053 BP_3 168.77 2.30 3822 602166190 AHN85842.1 1751 2.3e-192 octopamine beta receptor 2 [Nicrophorus vespilloides] -- -- -- -- -- K04160 HTR4 5-hydroxytryptamine receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04160 Q4LBB9 1334 2.1e-145 Octopamine receptor beta-2R OS=Drosophila melanogaster GN=Octbeta2R PE=2 SV=2 PF01769//PF00001 Divalent cation transporter//7 transmembrane receptor (rhodopsin family) GO:0006812//GO:0007186 cation transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0008324 G-protein coupled receptor activity//cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.23055 BP_3 426.00 9.95 2356 755944119 XP_011299351.1 1303 1.2e-140 PREDICTED: NADPH:adrenodoxin oxidoreductase, mitochondrial [Fopius arisanus]>gi|755944122|ref|XP_011299352.1| PREDICTED: NADPH:adrenodoxin oxidoreductase, mitochondrial [Fopius arisanus]>gi|755944125|ref|XP_011299353.1| PREDICTED: NADPH:adrenodoxin oxidoreductase, mitochondrial [Fopius arisanus] -- -- -- -- -- K18914 FDXR adrenodoxin-NADP+ reductase http://www.genome.jp/dbget-bin/www_bget?ko:K18914 Q9V3T9 1139 5.3e-123 NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Drosophila melanogaster GN=dare PE=2 SV=1 PF00163//PF07992//PF06156//PF01494//PF01479 Ribosomal protein S4/S9 N-terminal domain//Pyridine nucleotide-disulphide oxidoreductase//Protein of unknown function (DUF972)//FAD binding domain//S4 domain GO:0006260//GO:0055114 DNA replication//oxidation-reduction process GO:0019843//GO:0003723//GO:0071949//GO:0016491 rRNA binding//RNA binding//FAD binding//oxidoreductase activity GO:0005622 intracellular KOG1800 Ferredoxin/adrenodoxin reductase Cluster-8309.23058 BP_3 114.08 1.53 3882 546682322 ERL92270.1 2218 1.6e-246 hypothetical protein D910_09587 [Dendroctonus ponderosae] 828212418 XM_004208898.2 42 7.9143e-10 PREDICTED: Hydra vulgaris protein VAC14 homolog (LOC100212842), mRNA K15305 VAC14, TAX1BP2 vacuole morphology and inheritance protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15305 Q5ZIW5 1562 7.8e-172 Protein VAC14 homolog OS=Gallus gallus GN=VAC14 PE=2 SV=1 PF02985//PF03719 HEAT repeat//Ribosomal protein S5, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0212 Uncharacterized conserved protein Cluster-8309.23059 BP_3 489.24 8.28 3138 642928829 XP_008195578.1 1400 9.3e-152 PREDICTED: protein VAC14 homolog [Tribolium castaneum] 828212418 XM_004208898.2 42 6.3833e-10 PREDICTED: Hydra vulgaris protein VAC14 homolog (LOC100212842), mRNA K15305 VAC14, TAX1BP2 vacuole morphology and inheritance protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15305 A2VE70 999 1.2e-106 Protein VAC14 homolog OS=Bos taurus GN=VAC14 PE=2 SV=1 PF07571//PF02985//PF03719 TAF6 C-terminal HEAT repeat domain//HEAT repeat//Ribosomal protein S5, C-terminal domain GO:0051090//GO:0006412//GO:0042254 regulation of sequence-specific DNA binding transcription factor activity//translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005634//GO:0005840 nucleus//ribosome KOG0212 Uncharacterized conserved protein Cluster-8309.23060 BP_3 29.96 0.62 2605 478253101 ENN73474.1 178 3.9e-10 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04508 Viral A-type inclusion protein repeat GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.23062 BP_3 760.65 46.87 1074 91079574 XP_966886.1 962 2.0e-101 PREDICTED: ubiquitin carboxyl-terminal hydrolase [Tribolium castaneum]>gi|270004456|gb|EFA00904.1| hypothetical protein TcasGA2_TC003809 [Tribolium castaneum] -- -- -- -- -- K05609 UCHL3, YUH1 ubiquitin carboxyl-terminal hydrolase L3 http://www.genome.jp/dbget-bin/www_bget?ko:K05609 P35122 640 1.8e-65 Ubiquitin carboxyl-terminal hydrolase OS=Drosophila melanogaster GN=Uch PE=2 SV=2 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006508//GO:0006511//GO:0016579 proteolysis//ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0004843//GO:0004221 ubiquitin-specific protease activity//obsolete ubiquitin thiolesterase activity GO:0005622 intracellular KOG1415 Ubiquitin C-terminal hydrolase UCHL1 Cluster-8309.23065 BP_3 6.38 0.36 1139 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23069 BP_3 17.26 0.41 2333 642932427 XP_008197107.1 1468 9.0e-160 PREDICTED: uncharacterized protein KIAA0195 isoform X2 [Tribolium castaneum]>gi|270012352|gb|EFA08800.1| hypothetical protein TcasGA2_TC006494 [Tribolium castaneum] 391330831 XM_003739808.1 45 1.01671e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 570 5.0e-57 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF03533//PF01844//PF02313 SPO11 homologue//HNH endonuclease//Fumarate reductase subunit D GO:0006106//GO:0007131 fumarate metabolic process//reciprocal meiotic recombination GO:0003676//GO:0003677//GO:0004519 nucleic acid binding//DNA binding//endonuclease activity GO:0016020 membrane -- -- Cluster-8309.2307 BP_3 1.59 0.77 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23070 BP_3 30.59 0.37 4306 642932427 XP_008197107.1 3906 0.0e+00 PREDICTED: uncharacterized protein KIAA0195 isoform X2 [Tribolium castaneum]>gi|270012352|gb|EFA08800.1| hypothetical protein TcasGA2_TC006494 [Tribolium castaneum] 391330831 XM_003739808.1 45 1.8886e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 1284 1.5e-139 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF01567//PF01844 Hantavirus glycoprotein G1//HNH endonuclease GO:0030683 evasion or tolerance by virus of host immune response GO:0003676//GO:0004519 nucleic acid binding//endonuclease activity GO:0019012 virion KOG4383 Uncharacterized conserved protein Cluster-8309.23071 BP_3 13.50 0.42 1824 478261315 ENN80731.1 500 1.2e-47 hypothetical protein YQE_02839, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q12767 259 4.5e-21 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23072 BP_3 89.34 2.23 2225 642915956 XP_008190826.1 2982 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein kinase C, brain isozyme-like [Tribolium castaneum] 642915955 XM_008192604.1 551 0 PREDICTED: Tribolium castaneum protein kinase C, brain isozyme-like (LOC656250), mRNA K02677 CPKC classical protein kinase C http://www.genome.jp/dbget-bin/www_bget?ko:K02677 P05130 2495 2.9e-280 Protein kinase C, brain isozyme OS=Drosophila melanogaster GN=Pkc53E PE=2 SV=2 PF07714//PF00168//PF00628//PF07649//PF00069//PF09472//PF00130 Protein tyrosine kinase//C2 domain//PHD-finger//C1-like domain//Protein kinase domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556//GO:0015948//GO:0006468//GO:0046656 oxidation-reduction process//intracellular signal transduction//methanogenesis//protein phosphorylation//folic acid biosynthetic process GO:0004672//GO:0047134//GO:0005524//GO:0030269//GO:0005515 protein kinase activity//protein-disulfide reductase activity//ATP binding//tetrahydromethanopterin S-methyltransferase activity//protein binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.23076 BP_3 162.00 3.90 2293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15497//PF14620 snRNA-activating protein complex subunit 19, SNAPc subunit 19//YpeB sporulation GO:0009847//GO:0006366//GO:0006384 spore germination//transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase III promoter GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.23078 BP_3 1.00 0.32 444 546678121 ERL88830.1 353 3.3e-31 hypothetical protein D910_06212 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VS29 139 9.0e-08 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23079 BP_3 228.64 4.23 2897 646695057 KDR08231.1 880 1.7e-91 hypothetical protein L798_01949 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9D9H8 520 3.9e-51 UPF0565 protein C2orf69 homolog OS=Mus musculus PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23080 BP_3 1.00 3.30 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23082 BP_3 12.49 0.70 1149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23083 BP_3 46.71 1.05 2442 675380592 KFM73494.1 157 9.9e-08 hypothetical protein X975_07201, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23086 BP_3 36.19 1.81 1254 762146544 XP_011456572.1 230 1.7e-16 PREDICTED: uncharacterized protein LOC105348724 [Crassostrea gigas]>gi|405962723|gb|EKC28372.1| hypothetical protein CGI_10023755 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23087 BP_3 27.12 0.57 2569 675380592 KFM73494.1 157 1.0e-07 hypothetical protein X975_07201, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23089 BP_3 13.76 0.44 1813 762146544 XP_011456572.1 232 1.5e-16 PREDICTED: uncharacterized protein LOC105348724 [Crassostrea gigas]>gi|405962723|gb|EKC28372.1| hypothetical protein CGI_10023755 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2309 BP_3 10.00 0.54 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23094 BP_3 172.90 4.31 2225 642921483 XP_008192888.1 2007 2.7e-222 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY0 219 2.4e-16 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.23095 BP_3 47.79 2.67 1154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23097 BP_3 1061.37 10.16 5326 270005284 EFA01732.1 1464 6.0e-159 hypothetical protein TcasGA2_TC007325 [Tribolium castaneum] -- -- -- -- -- K05694 PTPRB, PTPB receptor-type tyrosine-protein phosphatase beta http://www.genome.jp/dbget-bin/www_bget?ko:K05694 P35992 618 3.1e-62 Tyrosine-protein phosphatase 10D OS=Drosophila melanogaster GN=Ptp10D PE=1 SV=4 PF00102//PF00041//PF00782 Protein-tyrosine phosphatase//Fibronectin type III domain//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0005515//GO:0008138//GO:0004725 protein binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG0791 Protein tyrosine phosphatase, contains fn3 domain Cluster-8309.23099 BP_3 141.73 4.89 1689 270001179 EEZ97626.1 307 2.8e-25 hypothetical protein TcasGA2_TC016074 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.231 BP_3 3.00 0.50 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06459//PF08070//PF11744 Ryanodine Receptor TM 4-6//DTHCT (NUC029) region//Aluminium activated malate transporter GO:0006816//GO:0015743//GO:0006265//GO:0006874 calcium ion transport//malate transport//DNA topological change//cellular calcium ion homeostasis GO:0005524//GO:0003677//GO:0005219//GO:0003918 ATP binding//DNA binding//ryanodine-sensitive calcium-release channel activity//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005634//GO:0016021//GO:0005622 nucleus//integral component of membrane//intracellular -- -- Cluster-8309.2310 BP_3 39.00 3.68 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23100 BP_3 225.27 1.98 5776 270008606 EFA05054.1 3313 0.0e+00 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 899 8.8e-95 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF00665//PF00098//PF13683 Integrase core domain//Zinc knuckle//Integrase core domain GO:0015074 DNA integration GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.23106 BP_3 216.00 176.09 345 189238541 XP_001812788.1 189 2.7e-12 PREDICTED: uncharacterized protein LOC100142146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15184 Mitochondrial import receptor subunit TOM6 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.2311 BP_3 28.00 6.24 508 557745702 AHA33381.1 572 1.5e-56 odorant-binding protein 3 [Batocera horsfieldi] 557745701 KC461117.1 369 0 Batocera horsfieldi odorant-binding protein 3 (obp3) mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.23113 BP_3 708.52 15.06 2559 546684133 ERL93838.1 1454 4.2e-158 hypothetical protein D910_11124, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IUS5 505 1.9e-49 Epoxide hydrolase 4 OS=Homo sapiens GN=EPHX4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4178 Soluble epoxide hydrolase Cluster-8309.23114 BP_3 44.66 1.32 1921 478251528 ENN71990.1 938 2.1e-98 hypothetical protein YQE_11281, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H8E8 646 6.3e-66 Cysteine-rich protein 2-binding protein OS=Homo sapiens GN=CSRP2BP PE=1 SV=3 PF00130//PF02576//PF13673//PF16866//PF00628//PF08445//PF13508//PF00583 Phorbol esters/diacylglycerol binding domain (C1 domain)//Putative ribosome maturation factor RimP//Acetyltransferase (GNAT) domain//PHD-finger//PHD-finger//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0035556//GO:0042967//GO:0042274 intracellular signal transduction//acyl-carrier-protein biosynthetic process//ribosomal small subunit biogenesis GO:0008080//GO:0016747//GO:0005515 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups//protein binding -- -- -- -- Cluster-8309.23121 BP_3 166.99 12.34 944 646708588 KDR14837.1 1260 4.8e-136 DNA-directed RNA polymerase II subunit RPB3 [Zootermopsis nevadensis] 751216889 XM_011163108.1 177 1.68512e-85 PREDICTED: Solenopsis invicta DNA-directed RNA polymerase II subunit RPB3 (LOC105196940), mRNA K03011 RPB3, POLR2C DNA-directed RNA polymerase II subunit RPB3 http://www.genome.jp/dbget-bin/www_bget?ko:K03011 P19387 1059 4.0e-114 DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens GN=POLR2C PE=1 SV=2 PF01000//PF01193 RNA polymerase Rpb3/RpoA insert domain//RNA polymerase Rpb3/Rpb11 dimerisation domain GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0046983//GO:0003899 protein dimerization activity//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG1522 RNA polymerase II, subunit POLR2C/RPB3 Cluster-8309.23123 BP_3 14.02 0.43 1856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23125 BP_3 7312.08 56.87 6489 642936252 XP_008198368.1 1210 2.1e-129 PREDICTED: titin-like isoform X1 [Tribolium castaneum]>gi|642936254|ref|XP_008198369.1| PREDICTED: titin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF03606 Chitin binding Peritrophin-A domain//C4-dicarboxylate anaerobic carrier GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.23126 BP_3 807.92 6.33 6442 642936252 XP_008198368.1 1206 6.0e-129 PREDICTED: titin-like isoform X1 [Tribolium castaneum]>gi|642936254|ref|XP_008198369.1| PREDICTED: titin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03606//PF01607 C4-dicarboxylate anaerobic carrier//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.23129 BP_3 57.86 3.00 1220 270008834 EFA05282.1 836 9.1e-87 hypothetical protein TcasGA2_TC015439 [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02599 388 3.3e-36 Calmodulin OS=Dictyostelium discoideum GN=calA PE=1 SV=3 PF12763//PF13202//PF13499//PF13405//PF10591//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.2313 BP_3 85.44 2.29 2089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23130 BP_3 102.00 2.41 2335 91094371 XP_970701.1 602 2.4e-59 PREDICTED: nicotinamide riboside kinase 1 [Tribolium castaneum]>gi|270014938|gb|EFA11386.1| hypothetical protein TcasGA2_TC011546 [Tribolium castaneum] -- -- -- -- -- K10524 NRK1_2 nicotinamide/nicotinate riboside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K10524 Q9NWW6 308 1.2e-26 Nicotinamide riboside kinase 1 OS=Homo sapiens GN=NMRK1 PE=1 SV=1 PF00485//PF08303 Phosphoribulokinase / Uridine kinase family//tRNA ligase kinase domain GO:0008152//GO:0006388 metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0003972//GO:0005524//GO:0016301 RNA ligase (ATP) activity//ATP binding//kinase activity -- -- -- -- Cluster-8309.23131 BP_3 16.15 0.31 2801 642911583 XP_008200661.1 1829 1.5e-201 PREDICTED: glutaminase liver isoform, mitochondrial isoform X1 [Tribolium castaneum] 766928101 XM_011497776.1 152 4.0405e-71 PREDICTED: Ceratosolen solmsi marchali glutaminase kidney isoform, mitochondrial (LOC105360775), mRNA K01425 glsA, GLS glutaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01425 D3Z7P3 1265 1.5e-137 Glutaminase kidney isoform, mitochondrial OS=Mus musculus GN=Gls PE=1 SV=1 PF04960//PF13606//PF00023//PF13499 Glutaminase//Ankyrin repeat//Ankyrin repeat//EF-hand domain pair GO:0006541 glutamine metabolic process GO:0005509//GO:0004359//GO:0005515 calcium ion binding//glutaminase activity//protein binding -- -- KOG0506 Glutaminase (contains ankyrin repeat) Cluster-8309.23132 BP_3 3.00 0.70 499 57868645 AAW57431.1 204 7.2e-14 10G08 [Ips pini] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23133 BP_3 27.76 0.53 2840 91089769 XP_967094.1 1002 1.2e-105 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 B4MYA4 520 3.8e-51 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.23135 BP_3 664.44 8.35 4125 642930684 XP_008199986.1 1049 6.2e-111 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum]>gi|642930686|ref|XP_008199987.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum]>gi|270012673|gb|EFA09121.1| hypothetical protein TcasGA2_TC015981 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AWG9 257 1.7e-20 Uncharacterized protein CG5098 OS=Drosophila melanogaster GN=CG5098 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23138 BP_3 47.14 3.71 904 91076494 XP_972946.1 288 2.4e-23 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 183 1.5e-12 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23139 BP_3 4.00 0.34 858 270001170 EEZ97617.1 138 5.5e-06 hypothetical protein TcasGA2_TC012951 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2314 BP_3 6488.56 173.14 2098 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02472 Biopolymer transport protein ExbD/TolR GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.23140 BP_3 340.92 4.43 3998 642910771 XP_008193403.1 2225 2.6e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.0e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00620//PF10297 RhoGAP domain//Minimal binding motif of Hap4 for binding to Hap2/3/5 GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.23141 BP_3 36.32 0.63 3058 642910771 XP_008193403.1 2110 4.3e-234 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0Q5 310 9.2e-27 Rho GTPase-activating protein 18 OS=Mus musculus GN=Arhgap18 PE=2 SV=1 PF10297//PF00620 Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.23146 BP_3 16.11 0.68 1439 478256535 ENN76719.1 563 4.9e-55 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P18715 350 1.0e-31 Gastrula zinc finger protein XlCGF26.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF00130//PF01197//PF02176//PF00096//PF03604//PF06467//PF07503//PF13465//PF16622//PF05191//PF04810//PF02892//PF13912//PF01363 Phorbol esters/diacylglycerol binding domain (C1 domain)//Ribosomal protein L31//TRAF-type zinc finger//Zinc finger, C2H2 type//DNA directed RNA polymerase, 7 kDa subunit//MYM-type Zinc finger with FCS sequence motif//HypF finger//Zinc-finger double domain//zinc-finger C2H2-type//Adenylate kinase, active site lid//Sec23/Sec24 zinc finger//BED zinc finger//C2H2-type zinc finger//FYVE zinc finger GO:0046034//GO:0006886//GO:0035556//GO:0042254//GO:0006144//GO:0006412//GO:0006888//GO:0006351//GO:0006206 ATP metabolic process//intracellular protein transport//intracellular signal transduction//ribosome biogenesis//purine nucleobase metabolic process//translation//ER to Golgi vesicle-mediated transport//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0004017//GO:0003735//GO:0008270//GO:0003677//GO:0046872 DNA-directed RNA polymerase activity//adenylate kinase activity//structural constituent of ribosome//zinc ion binding//DNA binding//metal ion binding GO:0030127//GO:0005730//GO:0005840//GO:0005622 COPII vesicle coat//nucleolus//ribosome//intracellular -- -- Cluster-8309.23147 BP_3 390.23 2.53 7720 642916594 XP_008191822.1 3184 0.0e+00 PREDICTED: alpha-catulin isoform X2 [Tribolium castaneum] 642916593 XM_008193600.1 726 0 PREDICTED: Tribolium castaneum alpha-catulin (LOC658111), transcript variant X2, mRNA -- -- -- -- Q9UBT7 1215 2.7e-131 Alpha-catulin OS=Homo sapiens GN=CTNNAL1 PE=1 SV=2 PF01044 Vinculin family GO:0007155 cell adhesion GO:0051015 actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.23148 BP_3 48.00 3.06 1048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23150 BP_3 35.00 20.75 370 642937868 XP_008200332.1 147 2.2e-07 PREDICTED: uncharacterized protein LOC661294 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.23151 BP_3 129.99 2.26 3070 573875180 XP_006625928.1 321 1.2e-26 PREDICTED: serine/threonine-protein kinase Nek2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- O35942 287 4.3e-24 Serine/threonine-protein kinase Nek2 OS=Mus musculus GN=Nek2 PE=1 SV=2 PF08040//PF00800//PF07714//PF00069 MNLL subunit//Prephenate dehydratase//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0000162//GO:0006571//GO:0006118//GO:0009094 protein phosphorylation//tryptophan biosynthetic process//tyrosine biosynthetic process//obsolete electron transport//L-phenylalanine biosynthetic process GO:0004664//GO:0003954//GO:0005524//GO:0004672 prephenate dehydratase activity//NADH dehydrogenase activity//ATP binding//protein kinase activity GO:0005739 mitochondrion -- -- Cluster-8309.23154 BP_3 206.16 12.39 1094 332374870 AEE62576.1 906 6.2e-95 unknown [Dendroctonus ponderosae]>gi|478262466|gb|ENN81137.1| hypothetical protein YQE_02504, partial [Dendroctonus ponderosae]>gi|546672779|gb|ERL84535.1| hypothetical protein D910_01965 [Dendroctonus ponderosae] -- -- -- -- -- K10847 XPA DNA-repair protein complementing XP-A cells http://www.genome.jp/dbget-bin/www_bget?ko:K10847 P28518 596 2.3e-60 DNA repair protein complementing XP-A cells homolog OS=Drosophila melanogaster GN=Xpac PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4017 DNA excision repair protein XPA/XPAC/RAD14 Cluster-8309.23156 BP_3 431.00 7.53 3052 270004396 EFA00844.1 370 2.5e-32 hypothetical protein TcasGA2_TC003732 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.23158 BP_3 11.26 0.79 979 642914292 XP_008201625.1 760 4.7e-78 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 O14733 649 1.5e-66 Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens GN=MAP2K7 PE=1 SV=2 PF05445//PF07714//PF00069 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0983 Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2 Cluster-8309.23159 BP_3 20.96 0.88 1437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23161 BP_3 22.00 3.10 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23162 BP_3 374.48 18.36 1275 91079458 XP_966537.1 882 4.4e-92 PREDICTED: SAP30-binding protein [Tribolium castaneum]>gi|270004398|gb|EFA00846.1| hypothetical protein TcasGA2_TC003747 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02614 375 1.1e-34 SAP30-binding protein OS=Mus musculus GN=Sap30bp PE=2 SV=2 PF07818 HCNGP-like protein GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.23163 BP_3 158.00 11.64 946 642927012 XP_008195103.1 342 1.3e-29 PREDICTED: RNA polymerase II-associated protein 3 [Tribolium castaneum]>gi|270010040|gb|EFA06488.1| hypothetical protein TcasGA2_TC009385 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKQ3 201 1.2e-14 RNA polymerase II-associated protein 3 OS=Gallus gallus GN=RPAP3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23167 BP_3 524.07 4.70 5670 189237519 XP_973030.2 3595 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.3e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF05485//PF03470//PF01667//PF13465 THAP domain//XS zinc finger domain//Ribosomal protein S27//Zinc-finger double domain GO:0042254//GO:0031047//GO:0006412 ribosome biogenesis//gene silencing by RNA//translation GO:0046872//GO:0003735//GO:0003676 metal ion binding//structural constituent of ribosome//nucleic acid binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.23169 BP_3 840.65 6.93 6141 189237519 XP_973030.2 3595 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.5e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF01667//PF03470//PF09367//PF13465//PF05485 Ribosomal protein S27//XS zinc finger domain//CpeS-like protein//Zinc-finger double domain//THAP domain GO:0031047//GO:0017009//GO:0042254//GO:0006412 gene silencing by RNA//protein-phycocyanobilin linkage//ribosome biogenesis//translation GO:0003735//GO:0003676//GO:0046872 structural constituent of ribosome//nucleic acid binding//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.2317 BP_3 7.00 0.45 1046 478255519 ENN75736.1 527 5.3e-51 hypothetical protein YQE_07696, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23171 BP_3 20.61 0.35 3162 478256655 ENN76837.1 496 6.3e-47 hypothetical protein YQE_06678, partial [Dendroctonus ponderosae]>gi|546685147|gb|ERL94674.1| hypothetical protein D910_11949 [Dendroctonus ponderosae] -- -- -- -- -- K04397 CASP7 caspase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04397 P97864 240 1.3e-18 Caspase-7 OS=Mus musculus GN=Casp7 PE=1 SV=2 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.23172 BP_3 148.39 7.02 1310 642932088 XP_975105.3 1247 2.1e-134 PREDICTED: acid phosphatase-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DH46 243 2.3e-19 2-phosphoxylose phosphatase 1 OS=Danio rerio GN=pxylp1 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- -- -- Cluster-8309.23174 BP_3 37.19 0.31 6032 478255769 ENN75978.1 183 2.4e-10 hypothetical protein YQE_07511, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00816//PF04905//PF07544//PF02179//PF07517 H-NS histone family//NAB conserved region 2 (NCD2)//RNA polymerase II transcription mediator complex subunit 9//BAG domain//SecA DEAD-like domain GO:0017038//GO:0006357//GO:0045892//GO:0006355 protein import//regulation of transcription from RNA polymerase II promoter//negative regulation of transcription, DNA-templated//regulation of transcription, DNA-templated GO:0001104//GO:0003677//GO:0005524//GO:0051087 RNA polymerase II transcription cofactor activity//DNA binding//ATP binding//chaperone binding GO:0005634//GO:0016592//GO:0005622//GO:0016020 nucleus//mediator complex//intracellular//membrane -- -- Cluster-8309.23175 BP_3 35.35 1.20 1714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00260 Protamine P1 GO:0007283 spermatogenesis GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.23177 BP_3 127.51 6.34 1261 270011665 EFA08113.1 656 7.0e-66 hypothetical protein TcasGA2_TC005717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IHQ9 220 1.0e-16 2-phosphoxylose phosphatase 1 OS=Xenopus tropicalis GN=pxylp1 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3672 Histidine acid phosphatase Cluster-8309.2318 BP_3 6.00 0.76 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23180 BP_3 142.96 1.33 5488 270014473 EFA10921.1 3056 0.0e+00 hypothetical protein TcasGA2_TC001747 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 1903 3.2e-211 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3578 Uncharacterized conserved protein Cluster-8309.23182 BP_3 2.00 1.06 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23183 BP_3 48.34 0.47 5223 91089365 XP_973210.1 1439 4.7e-156 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Tribolium castaneum]>gi|642933115|ref|XP_008197263.1| PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Tribolium castaneum]>gi|270012525|gb|EFA08973.1| hypothetical protein TcasGA2_TC006680 [Tribolium castaneum] 642933114 XM_008199041.1 236 1.52867e-117 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC661989), transcript variant X2, mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 Q9XZV3 792 2.0e-82 Guanine nucleotide-binding protein G(o) subunit alpha OS=Geodia cydonium PE=2 SV=3 PF00503//PF04670//PF00025//PF08477//PF07931 G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//Chloramphenicol phosphotransferase-like protein GO:0007165//GO:0007264//GO:0007186 signal transduction//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0016740//GO:0031683//GO:0005524//GO:0004871//GO:0019001//GO:0005525 GTPase activity//transferase activity//G-protein beta/gamma-subunit complex binding//ATP binding//signal transducer activity//guanyl nucleotide binding//GTP binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.23184 BP_3 8.00 0.42 1215 270015672 EFA12120.1 178 1.8e-10 hypothetical protein TcasGA2_TC002266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23185 BP_3 56.99 0.43 6700 270004778 EFA01226.1 1771 1.9e-194 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1242 1.7e-134 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683//PF06657//PF12513 Integrase core domain//Integrase core domain//Centrosome microtubule-binding domain of Cep57//Mitochondrial degradasome RNA helicase subunit C terminal GO:0015074 DNA integration GO:0016817//GO:0008017 hydrolase activity, acting on acid anhydrides//microtubule binding GO:0045298 tubulin complex KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.23187 BP_3 138.81 8.29 1099 91077040 XP_967879.1 577 8.8e-57 PREDICTED: signal recognition particle 19 kDa protein [Tribolium castaneum]>gi|270001745|gb|EEZ98192.1| hypothetical protein TcasGA2_TC000621 [Tribolium castaneum] -- -- -- -- -- K03105 SRP19 signal recognition particle subunit SRP19 http://www.genome.jp/dbget-bin/www_bget?ko:K03105 P49963 413 3.8e-39 Signal recognition particle 19 kDa protein OS=Drosophila melanogaster GN=Srp19 PE=2 SV=2 PF01922 SRP19 protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle KOG3198 Signal recognition particle, subunit Srp19 Cluster-8309.23188 BP_3 42.23 6.52 604 91078256 XP_970842.1 642 1.4e-64 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95373 394 3.3e-37 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008565//GO:0008536 protein transporter activity//Ran GTPase binding GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.23189 BP_3 337.68 5.66 3168 91078256 XP_970842.1 4084 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 817222787 XM_012431314.1 53 4.94719e-16 PREDICTED: Orussus abietinus importin-7 (LOC105703158), mRNA -- -- -- -- O95373 2647 9.8e-298 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008565//GO:0008536 protein transporter activity//Ran GTPase binding GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.23191 BP_3 17.83 0.73 1469 270008020 EFA04468.1 1192 5.7e-128 hypothetical protein TcasGA2_TC014772 [Tribolium castaneum] 195493568 XM_002094438.1 135 5.91117e-62 Drosophila yakuba GE20183 (Dyak\GE20183), partial mRNA -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23192 BP_3 2343.23 7.35 15660 642914247 XP_008201606.1 19704 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10506 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF00028//PF00008//PF08717//PF07645 Cadherin domain//EGF-like domain//nsp8 replicase//Calcium-binding EGF domain GO:0006508//GO:0007156 proteolysis//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0004197//GO:0008242//GO:0016740//GO:0005515 calcium ion binding//cysteine-type endopeptidase activity//omega peptidase activity//transferase activity//protein binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.23195 BP_3 24.00 8.76 423 270016078 EFA12526.1 164 2.6e-09 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23196 BP_3 11.00 0.51 1330 546676979 ERL87903.1 547 3.2e-53 hypothetical protein D910_05291 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 291 6.4e-25 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.23198 BP_3 2.00 0.35 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23199 BP_3 206.78 3.65 3025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2320 BP_3 230.67 185.39 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23200 BP_3 3.00 0.45 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23201 BP_3 535.59 23.48 1391 859132824 AKO63323.1 955 1.6e-100 isopentenyl diphosphate delta isomerase [Leptinotarsa decemlineata] -- -- -- -- -- K01823 idi, IDI isopentenyl-diphosphate delta-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01823 P58044 571 2.3e-57 Isopentenyl-diphosphate Delta-isomerase 1 OS=Mus musculus GN=Idi1 PE=2 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG0142 Isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase Cluster-8309.23205 BP_3 294.00 7.03 2308 546672651 ERL84447.1 2083 4.3e-231 hypothetical protein D910_01879 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGZ1 1646 8.4e-182 CDK5RAP1-like protein OS=Drosophila melanogaster GN=CG6345 PE=2 SV=1 PF00919//PF04055 Uncharacterized protein family UPF0004//Radical SAM superfamily GO:0009451 RNA modification GO:0051539//GO:0003824//GO:0051536 4 iron, 4 sulfur cluster binding//catalytic activity//iron-sulfur cluster binding -- -- KOG2492 CDK5 activator-binding protein Cluster-8309.23208 BP_3 416.12 5.35 4041 642937864 XP_008200330.1 2824 0.0e+00 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEP1 1762 5.2e-195 Protein FAM91A1 OS=Danio rerio GN=fam91a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.23209 BP_3 49.13 0.51 4908 642937864 XP_008200330.1 1807 9.3e-199 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVG3 1086 1.5e-116 Protein FAM91A1 OS=Mus musculus GN=Fam91a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.2321 BP_3 6.00 0.78 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23211 BP_3 4.00 0.33 880 260782884 XP_002586510.1 221 1.4e-15 hypothetical protein BRAFLDRAFT_106413 [Branchiostoma floridae]>gi|229271625|gb|EEN42521.1| hypothetical protein BRAFLDRAFT_106413 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07649//PF02150//PF00096//PF05201 C1-like domain//RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Glutamyl-tRNAGlu reductase, N-terminal domain GO:0055114//GO:0006206//GO:0006144//GO:0033014//GO:0006351 oxidation-reduction process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//tetrapyrrole biosynthetic process//transcription, DNA-templated GO:0047134//GO:0046872//GO:0003899//GO:0003677//GO:0008883//GO:0050661 protein-disulfide reductase activity//metal ion binding//DNA-directed RNA polymerase activity//DNA binding//glutamyl-tRNA reductase activity//NADP binding GO:0005730 nucleolus -- -- Cluster-8309.23215 BP_3 21.00 3.83 556 260810939 XP_002600180.1 249 4.8e-19 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q8VIG1 152 3.5e-09 RE1-silencing transcription factor OS=Mus musculus GN=Rest PE=1 SV=2 PF07649//PF00628//PF00130//PF13465//PF00096 C1-like domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0047134//GO:0046872//GO:0005515 protein-disulfide reductase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.23216 BP_3 64.00 0.51 6292 300394168 ADK11710.1 1641 2.1e-179 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P91885 919 4.6e-97 Aminopeptidase N OS=Manduca sexta GN=APN2 PE=1 SV=2 PF01433//PF03100 Peptidase family M1//CcmE GO:0017003//GO:0017004 protein-heme linkage//cytochrome complex assembly GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.23219 BP_3 25.10 1.86 943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00811 Ependymin GO:0007160 cell-matrix adhesion GO:0005509 calcium ion binding GO:0005576 extracellular region -- -- Cluster-8309.2322 BP_3 49.53 1.16 2352 91086895 XP_970738.1 225 1.2e-15 PREDICTED: probable cytochrome P450 49a1 [Tribolium castaneum]>gi|270011073|gb|EFA07521.1| cytochrome P450 49A1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 181 6.5e-12 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 -- -- GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0005506//GO:0004497//GO:0020037//GO:0009055//GO:0016705 iron ion binding//monooxygenase activity//heme binding//electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.23220 BP_3 43.73 0.66 3478 642920124 XP_008192216.1 1560 2.9e-170 PREDICTED: microtubule-associated protein futsch isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q869E1 144 1.9e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23221 BP_3 57.17 0.75 3956 642920124 XP_008192216.1 1477 1.4e-160 PREDICTED: microtubule-associated protein futsch isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q869E1 146 1.2e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 PF01537 Herpesvirus glycoprotein D/GG/GX domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.23224 BP_3 141.93 5.82 1468 282165774 NP_001164128.1 1052 9.8e-112 cardiolipin synthase 1 [Tribolium castaneum] -- -- -- -- -- K08744 CRLS cardiolipin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K08744 Q8MZC4 652 9.8e-67 Probable cardiolipin synthase (CMP-forming) OS=Drosophila melanogaster GN=CLS PE=2 SV=1 PF01066//PF01896//PF01017//PF16818 CDP-alcohol phosphatidyltransferase//Eukaryotic and archaeal DNA primase small subunit//STAT protein, all-alpha domain//Protein SLM4 GO:0016237//GO:0006351//GO:0007165//GO:0008654//GO:0006269//GO:0006355 lysosomal microautophagy//transcription, DNA-templated//signal transduction//phospholipid biosynthetic process//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated GO:0003896//GO:0016780//GO:0003700//GO:0004871 DNA primase activity//phosphotransferase activity, for other substituted phosphate groups//transcription factor activity, sequence-specific DNA binding//signal transducer activity GO:0005667//GO:0005657//GO:0005730//GO:0016020//GO:0034448 transcription factor complex//replication fork//nucleolus//membrane//EGO complex KOG1617 CDP-alcohol phosphatidyltransferase/Phosphatidylglycerol-phosphate synthase Cluster-8309.23225 BP_3 22.00 0.44 2704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23226 BP_3 6.00 0.81 648 255522801 NP_001157313.1 197 6.0e-13 longitudinals lacking isoform 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF02150//PF13465//PF00096 C2H2-type zinc finger//RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0046872//GO:0003899//GO:0003677 metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.23227 BP_3 35.08 0.34 5203 815810119 XP_012225949.1 195 8.3e-12 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q9V5M3 135 3.1e-06 Longitudinals lacking protein, isoforms N/O/W/X/Y OS=Drosophila melanogaster GN=lola PE=1 SV=3 PF13465//PF02176//PF00096//PF01363//PF13912 Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type//FYVE zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.23228 BP_3 212.99 1.62 6624 478251279 ENN71750.1 2240 7.8e-249 hypothetical protein YQE_11570, partial [Dendroctonus ponderosae]>gi|478251283|gb|ENN71754.1| hypothetical protein YQE_11574, partial [Dendroctonus ponderosae] -- -- -- -- -- K14809 DDX55, SPB4 ATP-dependent RNA helicase DDX55/SPB4 http://www.genome.jp/dbget-bin/www_bget?ko:K14809 Q9VHU1 1497 4.6e-164 Probable ATP-dependent RNA helicase DDX55 homolog OS=Drosophila melanogaster GN=CG9630 PE=2 SV=1 PF04851//PF07544//PF00270 Type III restriction enzyme, res subunit//RNA polymerase II transcription mediator complex subunit 9//DEAD/DEAH box helicase GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0016787//GO:0003677//GO:0003676//GO:0005524 RNA polymerase II transcription cofactor activity//hydrolase activity//DNA binding//nucleic acid binding//ATP binding GO:0016592 mediator complex KOG0345 ATP-dependent RNA helicase Cluster-8309.2323 BP_3 32.23 1.02 1808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23230 BP_3 1056.60 8.20 6500 478251279 ENN71750.1 2240 7.6e-249 hypothetical protein YQE_11570, partial [Dendroctonus ponderosae]>gi|478251283|gb|ENN71754.1| hypothetical protein YQE_11574, partial [Dendroctonus ponderosae] -- -- -- -- -- K14809 DDX55, SPB4 ATP-dependent RNA helicase DDX55/SPB4 http://www.genome.jp/dbget-bin/www_bget?ko:K14809 Q9VHU1 1497 4.5e-164 Probable ATP-dependent RNA helicase DDX55 homolog OS=Drosophila melanogaster GN=CG9630 PE=2 SV=1 PF07544//PF00270//PF04851 RNA polymerase II transcription mediator complex subunit 9//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0003677//GO:0016787//GO:0003676//GO:0005524 RNA polymerase II transcription cofactor activity//DNA binding//hydrolase activity//nucleic acid binding//ATP binding GO:0016592 mediator complex KOG0345 ATP-dependent RNA helicase Cluster-8309.23231 BP_3 159.32 1.23 6556 478251279 ENN71750.1 2193 2.2e-243 hypothetical protein YQE_11570, partial [Dendroctonus ponderosae]>gi|478251283|gb|ENN71754.1| hypothetical protein YQE_11574, partial [Dendroctonus ponderosae] -- -- -- -- -- K14809 DDX55, SPB4 ATP-dependent RNA helicase DDX55/SPB4 http://www.genome.jp/dbget-bin/www_bget?ko:K14809 Q9VHU1 1446 3.7e-158 Probable ATP-dependent RNA helicase DDX55 homolog OS=Drosophila melanogaster GN=CG9630 PE=2 SV=1 PF07544//PF00270//PF04851 RNA polymerase II transcription mediator complex subunit 9//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0005524//GO:0003676//GO:0016787//GO:0003677//GO:0001104 ATP binding//nucleic acid binding//hydrolase activity//DNA binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG0345 ATP-dependent RNA helicase Cluster-8309.23233 BP_3 20.00 1.12 1150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23235 BP_3 22.92 1.02 1373 478251391 ENN71857.1 259 8.3e-20 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 P54726 159 1.3e-09 UV excision repair protein RAD23 homolog A OS=Mus musculus GN=Rad23a PE=1 SV=2 PF09280//PF00995 XPC-binding domain//Sec1 family GO:0043161//GO:0006281//GO:0016192//GO:0006289//GO:0006904 proteasome-mediated ubiquitin-dependent protein catabolic process//DNA repair//vesicle-mediated transport//nucleotide-excision repair//vesicle docking involved in exocytosis GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.23236 BP_3 8.61 2.83 438 546673559 ERL85134.1 168 9.4e-10 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23239 BP_3 309.82 8.76 1996 642925855 XP_008190573.1 1545 9.1e-169 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VC27 842 1.2e-88 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF05450 Nicastrin GO:0016485 protein processing -- -- GO:0016021 integral component of membrane KOG2657 Transmembrane glycoprotein nicastrin Cluster-8309.23242 BP_3 1.29 0.39 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23244 BP_3 178.00 5.59 1827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23246 BP_3 754.47 8.99 4337 642924799 XP_008194045.1 2141 1.5e-237 PREDICTED: aspartate--tRNA ligase, mitochondrial [Tribolium castaneum] 701168938 CP007711.1 38 1.48102e-07 Candidatus Mycoplasma girerdii strain VCU_M1, complete genome K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 Q3KRD0 1437 2.7e-157 Aspartate--tRNA ligase, mitochondrial OS=Rattus norvegicus GN=Dars2 PE=1 SV=1 PF07500//PF01096//PF01336//PF00152//PF07700//PF01409//PF08711 Transcription factor S-II (TFIIS), central domain//Transcription factor S-II (TFIIS)//OB-fold nucleic acid binding domain//tRNA synthetases class II (D, K and N)//Haem-NO-binding//tRNA synthetases class II core domain (F)//TFIIS helical bundle-like domain GO:0006351//GO:0006418//GO:0043039 transcription, DNA-templated//tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0003677//GO:0005524//GO:0000049//GO:0003676//GO:0000166//GO:0008270//GO:0004812//GO:0020037 DNA binding//ATP binding//tRNA binding//nucleic acid binding//nucleotide binding//zinc ion binding//aminoacyl-tRNA ligase activity//heme binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG2411 Aspartyl-tRNA synthetase, mitochondrial Cluster-8309.23249 BP_3 36.67 0.37 5089 270006699 EFA03147.1 1430 5.0e-155 hypothetical protein TcasGA2_TC013060 [Tribolium castaneum] 701168938 CP007711.1 38 1.73996e-07 Candidatus Mycoplasma girerdii strain VCU_M1, complete genome K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 Q3KRD0 968 7.7e-103 Aspartate--tRNA ligase, mitochondrial OS=Rattus norvegicus GN=Dars2 PE=1 SV=1 PF00587//PF00152//PF08711//PF01409//PF07500//PF01336//PF01096//PF07700 tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N)//TFIIS helical bundle-like domain//tRNA synthetases class II core domain (F)//Transcription factor S-II (TFIIS), central domain//OB-fold nucleic acid binding domain//Transcription factor S-II (TFIIS)//Haem-NO-binding GO:0043039//GO:0006418//GO:0006351 tRNA aminoacylation//tRNA aminoacylation for protein translation//transcription, DNA-templated GO:0004812//GO:0020037//GO:0000166//GO:0008270//GO:0003676//GO:0000049//GO:0005524//GO:0003677 aminoacyl-tRNA ligase activity//heme binding//nucleotide binding//zinc ion binding//nucleic acid binding//tRNA binding//ATP binding//DNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG2411 Aspartyl-tRNA synthetase, mitochondrial Cluster-8309.23251 BP_3 33.73 1.02 1882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23252 BP_3 11.50 0.39 1720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23254 BP_3 29.16 0.61 2601 642939462 XP_008200412.1 1448 2.1e-157 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [Tribolium castaneum]>gi|270016524|gb|EFA12970.1| immune response deficient 5 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 622 5.2e-63 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF00069//PF06293//PF01213//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Adenylate cyclase associated (CAP) N terminal//Protein tyrosine kinase GO:0007010//GO:0006468 cytoskeleton organization//protein phosphorylation GO:0016773//GO:0005524//GO:0003779//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//actin binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.23257 BP_3 41.48 0.33 6300 807015446 XP_012155254.1 2269 3.2e-252 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101458667 [Ceratitis capitata] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2189 2.5e-244 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00564//PF00130//PF00433//PF00628//PF07649//PF07714//PF00069 PB1 domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase C terminal domain//PHD-finger//C1-like domain//Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468//GO:0055114//GO:0035556 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0004674//GO:0047134//GO:0004672 ATP binding//protein binding//protein serine/threonine kinase activity//protein-disulfide reductase activity//protein kinase activity -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.23259 BP_3 38.09 0.74 2767 91084211 XP_968214.1 428 4.2e-39 PREDICTED: transcriptional adapter 3 [Tribolium castaneum]>gi|270008765|gb|EFA05213.1| hypothetical protein TcasGA2_TC015353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66IZ5 310 8.4e-27 Transcriptional adapter 3-B OS=Xenopus laevis GN=tada3-b PE=2 SV=1 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.23261 BP_3 413.70 8.66 2593 642935548 XP_008198054.1 622 1.3e-61 PREDICTED: caspase-7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55210 312 4.6e-27 Caspase-7 OS=Homo sapiens GN=CASP7 PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.23262 BP_3 53.39 0.87 3258 478256655 ENN76837.1 496 6.5e-47 hypothetical protein YQE_06678, partial [Dendroctonus ponderosae]>gi|546685147|gb|ERL94674.1| hypothetical protein D910_11949 [Dendroctonus ponderosae] -- -- -- -- -- K04397 CASP7 caspase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04397 P97864 240 1.3e-18 Caspase-7 OS=Mus musculus GN=Casp7 PE=1 SV=2 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.23264 BP_3 242.71 1.71 7147 270003541 EEZ99988.1 3167 0.0e+00 hypothetical protein TcasGA2_TC002791 [Tribolium castaneum] 805798528 XM_012288489.1 131 4.90128e-59 PREDICTED: Megachile rotundata calponin homology domain-containing protein DDB_G0272472 (LOC100882081), transcript variant X2, mRNA K11478 JARID2, JMJ protein Jumonji http://www.genome.jp/dbget-bin/www_bget?ko:K11478 Q5F363 922 2.3e-97 Protein Jumonji OS=Gallus gallus GN=JARID2 PE=2 SV=1 PF02861//PF01388 Clp amino terminal domain, pathogenicity island component//ARID/BRIGHT DNA binding domain GO:0019538 protein metabolic process GO:0003677 DNA binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.23268 BP_3 1.00 2.07 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2327 BP_3 57.02 2.48 1398 134031943 NP_001076796.1 1323 3.5e-143 cardioacceleratory peptide receptor 1 [Tribolium castaneum]>gi|126116538|gb|ABN79651.1| cardioactive peptide receptor 1 [Tribolium castaneum]>gi|270012688|gb|EFA09136.1| hypothetical protein TcasGA2_TC002216 [Tribolium castaneum]>gi|485836800|tpg|DAA64485.1| TPA_inf: CCAP-like G protein-coupled receptor 2 [Tribolium castaneum] -- -- -- -- -- K08376 NPSR1, GPR154 neuropeptide S receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08376 Q868T3 1004 1.4e-107 Cardioacceleratory peptide receptor OS=Drosophila melanogaster GN=CCAP-R PE=2 SV=3 PF02118//PF00001 Srg family chemoreceptor//7 transmembrane receptor (rhodopsin family) GO:0007187//GO:0007165//GO:0007606//GO:0007186 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//signal transduction//sensory perception of chemical stimulus//G-protein coupled receptor signaling pathway GO:0004930//GO:0004888//GO:0005000 G-protein coupled receptor activity//transmembrane signaling receptor activity//vasopressin receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.23272 BP_3 26.03 0.58 2444 195117344 XP_002003207.1 147 1.4e-06 GI17786 [Drosophila mojavensis]>gi|193913782|gb|EDW12649.1| GI17786 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04494//PF00050//PF07648 WD40 associated region in TFIID subunit, NTD2 domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.23274 BP_3 120.06 5.80 1289 91089157 XP_973708.1 545 5.3e-53 PREDICTED: uncharacterized protein LOC662524 [Tribolium castaneum]>gi|270012450|gb|EFA08898.1| hypothetical protein TcasGA2_TC006599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0032222//GO:1903818//GO:0030431 regulation of synaptic transmission, cholinergic//positive regulation of voltage-gated potassium channel activity//sleep GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.23275 BP_3 309.17 2.11 7354 642935211 XP_008199691.1 1937 1.2e-213 PREDICTED: RNA-binding protein Musashi homolog Rbp6 isoform X1 [Tribolium castaneum] 642935210 XM_008201469.1 874 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog Rbp6 (LOC656553), transcript variant X1, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q9VVE5 1441 1.6e-157 RNA-binding protein Musashi homolog Rbp6 OS=Drosophila melanogaster GN=Rbp6 PE=2 SV=3 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.23276 BP_3 63.40 1.53 2283 91083931 XP_974830.1 838 1.0e-86 PREDICTED: N-acetylserotonin O-methyltransferase-like protein [Tribolium castaneum]>gi|270007966|gb|EFA04414.1| hypothetical protein TcasGA2_TC014714 [Tribolium castaneum] -- -- -- -- -- K06287 maf septum formation protein http://www.genome.jp/dbget-bin/www_bget?ko:K06287 O95671 336 6.7e-30 N-acetylserotonin O-methyltransferase-like protein OS=Homo sapiens GN=ASMTL PE=1 SV=3 PF02545 Maf-like protein -- -- -- -- GO:0005737 cytoplasm KOG1509 Predicted nucleic acid-binding protein ASMTL Cluster-8309.23279 BP_3 176.04 1.67 5381 642929679 XP_975498.3 2932 0.0e+00 PREDICTED: metastasis-associated protein MTA3 isoform X2 [Tribolium castaneum] 768415855 XM_011550194.1 183 4.56965e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1635 3.7e-180 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF00320//PF01426//PF00096 GATA zinc finger//BAH domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0046872//GO:0003682//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//metal ion binding//chromatin binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0000785 transcription factor complex//chromatin KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.23280 BP_3 260.81 2.13 6184 642929679 XP_975498.3 2932 0.0e+00 PREDICTED: metastasis-associated protein MTA3 isoform X2 [Tribolium castaneum] 768415855 XM_011550194.1 183 5.25617e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1635 4.3e-180 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF01426//PF00096//PF00320 BAH domain//Zinc finger, C2H2 type//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003682//GO:0003700//GO:0043565//GO:0008270 metal ion binding//chromatin binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0000785 transcription factor complex//chromatin KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.23281 BP_3 534.06 11.27 2576 270009558 EFA06006.1 3202 0.0e+00 hypothetical protein TcasGA2_TC008832 [Tribolium castaneum] 768415855 XM_011550194.1 183 2.17308e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1641 3.6e-181 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF00096//PF01426//PF00320 Zinc finger, C2H2 type//BAH domain//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003682//GO:0046872//GO:0003700 zinc ion binding//sequence-specific DNA binding//chromatin binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0000785//GO:0005667 chromatin//transcription factor complex KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.23282 BP_3 74.24 1.01 3843 642932696 XP_008196948.1 1875 9.5e-207 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17085//PF10473//PF02183//PF06367//PF06371 Unique cartilage matrix associated protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Homeobox associated leucine zipper//Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0016043//GO:0045667//GO:0030036//GO:0006355 cellular component organization//regulation of osteoblast differentiation//actin cytoskeleton organization//regulation of transcription, DNA-templated GO:0003779//GO:0045502//GO:0008134//GO:0017048//GO:0003700//GO:0042803//GO:0043565 actin binding//dynein binding//transcription factor binding//Rho GTPase binding//transcription factor activity, sequence-specific DNA binding//protein homodimerization activity//sequence-specific DNA binding GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.23283 BP_3 32.22 1.13 1665 642918006 XP_971827.2 216 9.7e-15 PREDICTED: N-alpha-acetyltransferase 60 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX8 178 1.0e-11 N-alpha-acetyltransferase 60 OS=Drosophila melanogaster GN=Naa60 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23284 BP_3 16.56 1.75 747 189236866 XP_001814181.1 265 9.1e-21 PREDICTED: LIRP [Tribolium castaneum]>gi|270006348|gb|EFA02796.1| insulin-like peptide [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15131 180 2.7e-12 LIRP OS=Locusta migratoria PE=1 SV=2 PF00049//PF03488 Insulin/IGF/Relaxin family//Nematode insulin-related peptide beta type GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.23285 BP_3 989.20 16.54 3174 91078790 XP_969765.1 2187 5.2e-243 PREDICTED: retinoblastoma-binding protein 5 [Tribolium castaneum]>gi|270003731|gb|EFA00179.1| hypothetical protein TcasGA2_TC003004 [Tribolium castaneum] 815929092 XM_003494688.2 345 2.36202e-178 PREDICTED: Bombus impatiens retinoblastoma-binding protein 5 homolog (LOC100746759), mRNA K14961 RBBP5, SWD1, CPS50 COMPASS component SWD1 http://www.genome.jp/dbget-bin/www_bget?ko:K14961 Q9VPH8 1867 2.7e-207 Retinoblastoma-binding protein 5 homolog OS=Drosophila melanogaster GN=Rbbp5 PE=1 SV=2 PF00400//PF01239//PF01459 WD domain, G-beta repeat//Protein prenyltransferase alpha subunit repeat//Eukaryotic porin GO:0018342//GO:0055085 protein prenylation//transmembrane transport GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity GO:0005741 mitochondrial outer membrane KOG1273 WD40 repeat protein Cluster-8309.23286 BP_3 64.00 6.06 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23287 BP_3 2.00 0.49 490 291170322 ADD82417.1 199 2.7e-13 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 111 4.13847e-49 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2329 BP_3 17.51 0.34 2769 478263128 ENN81521.1 806 6.2e-83 hypothetical protein YQE_02050, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23292 BP_3 10.00 4.60 395 390362249 XP_001190749.2 261 1.4e-20 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 257 1.7e-21 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF05396 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.23293 BP_3 31.00 5.35 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23295 BP_3 51.58 0.96 2875 642917947 XP_008198954.1 1422 2.4e-154 PREDICTED: SNF-related serine/threonine-protein kinase [Tribolium castaneum] 828210619 XM_004208630.2 127 3.27589e-57 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 1242 7.4e-135 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG4717 Serine/threonine protein kinase Cluster-8309.23298 BP_3 288.00 17.41 1089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2330 BP_3 515.49 10.98 2554 478263128 ENN81521.1 829 1.2e-85 hypothetical protein YQE_02050, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23300 BP_3 331.00 20.34 1076 170047211 XP_001851125.1 538 2.9e-52 adrenodoxin [Culex quinquefasciatus]>gi|167869695|gb|EDS33078.1| adrenodoxin [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- P10109 372 2.1e-34 Adrenodoxin, mitochondrial OS=Homo sapiens GN=FDX1 PE=1 SV=1 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0051537//GO:0009055//GO:0051536//GO:0046872 2 iron, 2 sulfur cluster binding//electron carrier activity//iron-sulfur cluster binding//metal ion binding -- -- KOG3309 Ferredoxin Cluster-8309.23302 BP_3 1146.00 12.96 4554 189236491 XP_001815774.1 2020 1.7e-223 PREDICTED: gem-associated protein 5 [Tribolium castaneum]>gi|270005977|gb|EFA02425.1| hypothetical protein TcasGA2_TC008111 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEQ6 407 7.8e-38 Gem-associated protein 5 OS=Homo sapiens GN=GEMIN5 PE=1 SV=3 PF13176//PF00400//PF05409 Tetratricopeptide repeat//WD domain, G-beta repeat//Coronavirus endopeptidase C30 GO:0019082 viral protein processing GO:0005515 protein binding -- -- -- -- Cluster-8309.23304 BP_3 82.61 0.75 5599 815769669 XP_012234959.1 1328 3.7e-143 PREDICTED: uncharacterized protein LOC105679478 [Linepithema humile] -- -- -- -- -- -- -- -- -- P34457 321 9.0e-28 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF02888//PF00503//PF01580//PF08398//PF03175//PF13683//PF00665 Calmodulin binding domain//G-protein alpha subunit//FtsK/SpoIIIE family//Parvovirus coat protein VP1//DNA polymerase type B, organellar and viral//Integrase core domain//Integrase core domain GO:0007186//GO:0006260//GO:0007165//GO:0015074//GO:0006813 G-protein coupled receptor signaling pathway//DNA replication//signal transduction//DNA integration//potassium ion transport GO:0000166//GO:0008408//GO:0019001//GO:0005198//GO:0003924//GO:0015269//GO:0005524//GO:0005516//GO:0031683//GO:0004871//GO:0003887//GO:0003677 nucleotide binding//3'-5' exonuclease activity//guanyl nucleotide binding//structural molecule activity//GTPase activity//calcium-activated potassium channel activity//ATP binding//calmodulin binding//G-protein beta/gamma-subunit complex binding//signal transducer activity//DNA-directed DNA polymerase activity//DNA binding GO:0042575//GO:0019028//GO:0016021 DNA polymerase complex//viral capsid//integral component of membrane -- -- Cluster-8309.23305 BP_3 14.78 0.54 1613 546672794 ERL84550.1 614 6.6e-61 hypothetical protein D910_01979 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6Q0N3 406 3.6e-38 5'-nucleotidase domain-containing protein 2 OS=Rattus norvegicus GN=Nt5dc2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2470 Similar to IMP-GMP specific 5'-nucleotidase Cluster-8309.23307 BP_3 211.00 15.64 942 478254420 ENN74672.1 768 5.4e-79 hypothetical protein YQE_08789, partial [Dendroctonus ponderosae] -- -- -- -- -- K04569 CCS copper chaperone for superoxide dismutase http://www.genome.jp/dbget-bin/www_bget?ko:K04569 Q9WU84 567 4.5e-57 Copper chaperone for superoxide dismutase OS=Mus musculus GN=Ccs PE=2 SV=1 PF00080//PF00403 Copper/zinc superoxide dismutase (SODC)//Heavy-metal-associated domain GO:0006801//GO:0030001//GO:0055114 superoxide metabolic process//metal ion transport//oxidation-reduction process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.23308 BP_3 89.47 3.98 1376 546682572 ERL92495.1 1341 2.8e-145 hypothetical protein D910_09808 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 385 8.4e-36 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.2331 BP_3 22.27 0.82 1603 332372612 AEE61448.1 372 7.6e-33 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23310 BP_3 83.99 2.51 1902 91076124 XP_969821.1 1149 7.2e-123 PREDICTED: protein tipE [Tribolium castaneum]>gi|270014713|gb|EFA11161.1| hypothetical protein TcasGA2_TC004765 [Tribolium castaneum] 462311136 APGK01047078.1 38 6.4309e-08 Dendroctonus ponderosae Seq01047088, whole genome shotgun sequence -- -- -- -- P48613 210 2.3e-15 Protein tipE OS=Drosophila melanogaster GN=tipE PE=2 SV=1 PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.23311 BP_3 12.29 0.47 1556 91076124 XP_969821.1 1012 4.5e-107 PREDICTED: protein tipE [Tribolium castaneum]>gi|270014713|gb|EFA11161.1| hypothetical protein TcasGA2_TC004765 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48613 170 8.1e-11 Protein tipE OS=Drosophila melanogaster GN=tipE PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23312 BP_3 10.87 0.32 1948 664780421 XP_008509530.1 282 2.5e-22 PREDICTED: zinc finger protein 709-like [Equus przewalskii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q32M78 277 4.0e-23 Zinc finger protein 699 OS=Homo sapiens GN=ZNF699 PE=1 SV=1 PF13912//PF16622//PF00096//PF13465//PF02146//PF01155//PF05443 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain//Sir2 family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//ROS/MUCR transcriptional regulator protein GO:0006355//GO:0006464 regulation of transcription, DNA-templated//cellular protein modification process GO:0008270//GO:0003677//GO:0070403//GO:0016151//GO:0046872 zinc ion binding//DNA binding//NAD+ binding//nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.23314 BP_3 18.00 1.13 1062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23317 BP_3 5.00 0.42 870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2332 BP_3 2115.36 61.60 1947 642927117 XP_008195144.1 1483 1.4e-161 PREDICTED: clavesin-2 isoform X1 [Tribolium castaneum] 642927118 XM_967037.3 161 2.77519e-76 PREDICTED: Tribolium castaneum clavesin-2 (LOC660834), transcript variant X2, mRNA -- -- -- -- A6JUQ6 313 2.6e-27 Clavesin-2 OS=Rattus norvegicus GN=Clvs2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23320 BP_3 4.00 0.49 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23323 BP_3 84.92 1.41 3196 642936222 XP_008198354.1 1070 1.8e-113 PREDICTED: glutamyl aminopeptidase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32LQ0 675 4.6e-69 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.23329 BP_3 213.00 6.94 1770 189242034 XP_001807841.1 819 1.2e-84 PREDICTED: STI1-like protein [Tribolium castaneum]>gi|270015919|gb|EFA12367.1| hypothetical protein TcasGA2_TC002073 [Tribolium castaneum] -- -- -- -- -- K09553 STIP1 stress-induced-phosphoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09553 Q8ILC1 231 7.7e-18 STI1-like protein OS=Plasmodium falciparum (isolate 3D7) GN=PF14_0324 PE=3 SV=1 PF13176//PF13414//PF00515//PF13181//PF13371 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0548 Molecular co-chaperone STI1 Cluster-8309.23333 BP_3 30.50 0.44 3609 91083441 XP_969909.1 870 3.1e-90 PREDICTED: retinal homeobox protein Rx-B [Tribolium castaneum]>gi|270008142|gb|EFA04590.1| reversed polarity [Tribolium castaneum] -- -- -- -- -- K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 O42115 247 2.2e-19 Aristaless-related homeobox protein OS=Danio rerio GN=arx PE=2 SV=1 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.23334 BP_3 224.78 3.74 3192 91083441 XP_969909.1 1199 1.9e-128 PREDICTED: retinal homeobox protein Rx-B [Tribolium castaneum]>gi|270008142|gb|EFA04590.1| reversed polarity [Tribolium castaneum] 462346959 APGK01034101.1 64 3.82655e-22 Dendroctonus ponderosae Seq01034111, whole genome shotgun sequence K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 O42115 218 4.5e-16 Aristaless-related homeobox protein OS=Danio rerio GN=arx PE=2 SV=1 PF00046//PF00487//PF05920//PF05478 Homeobox domain//Fatty acid desaturase//Homeobox KN domain//Prominin GO:0006629//GO:0006355 lipid metabolic process//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0016021 integral component of membrane KOG0490 Transcription factor, contains HOX domain Cluster-8309.23335 BP_3 42.19 0.61 3649 642925833 XP_008190490.1 4506 0.0e+00 PREDICTED: jmjC domain-containing histone demethylation protein 1 isoform X2 [Tribolium castaneum] 602630683 XM_007422193.1 38 1.24411e-07 PREDICTED: Python bivittatus PHD finger protein 8 (PHF8), transcript variant X4, mRNA K10276 FBXL10_11, KDM2 F-box and leucine-rich repeat protein 10/11 http://www.genome.jp/dbget-bin/www_bget?ko:K10276 Q9VHH9 1609 2.6e-177 JmjC domain-containing histone demethylation protein 1 OS=Drosophila melanogaster GN=Kdm2 PE=1 SV=2 PF13855//PF12937//PF00646//PF02008//PF16866 Leucine rich repeat//F-box-like//F-box domain//CXXC zinc finger domain//PHD-finger -- -- GO:0005515//GO:0003677//GO:0008270 protein binding//DNA binding//zinc ion binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.23337 BP_3 111.20 3.86 1679 546681837 ERL91852.1 1147 1.1e-122 hypothetical protein D910_09177 [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q08DK4 745 1.8e-77 Mitochondrial glutamate carrier 1 OS=Bos taurus GN=SLC25A22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0750 Mitochondrial solute carrier protein Cluster-8309.23339 BP_3 125.04 1.77 3691 478251486 ENN71949.1 495 9.6e-47 hypothetical protein YQE_11383, partial [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q08DK4 299 2.1e-25 Mitochondrial glutamate carrier 1 OS=Bos taurus GN=SLC25A22 PE=2 SV=1 PF00519 Papillomavirus helicase GO:0006260 DNA replication GO:0005524//GO:0003677//GO:0004003 ATP binding//DNA binding//ATP-dependent DNA helicase activity GO:0005657 replication fork KOG0750 Mitochondrial solute carrier protein Cluster-8309.2334 BP_3 244.67 2.41 5186 546684191 ERL93896.1 1257 5.9e-135 hypothetical protein D910_11182, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P54316 373 7.8e-34 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23341 BP_3 157.59 11.90 930 642915536 XP_008190656.1 775 8.2e-80 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] 572317138 XM_006624115.1 117 3.74726e-52 PREDICTED: Apis dorsata uncharacterized LOC102679271 (LOC102679271), transcript variant X3, mRNA -- -- -- -- Q8IQC1 557 6.4e-56 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.23342 BP_3 9.00 4.94 377 751442604 XP_011195955.1 225 2.0e-16 PREDICTED: uncharacterized protein DDB_G0290301 isoform X1 [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q00690 147 9.0e-09 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23343 BP_3 3.55 0.36 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23346 BP_3 38.72 1.51 1530 642939160 XP_969591.2 879 1.2e-91 PREDICTED: protein D3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 625 1.4e-63 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.23347 BP_3 26.00 3.25 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23348 BP_3 84.56 0.73 5861 270006429 EFA02877.1 2890 0.0e+00 hypothetical protein TcasGA2_TC008029 [Tribolium castaneum] -- -- -- -- -- K17495 CSMD CUB and sushi domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K17495 P0C6B8 1414 1.7e-154 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus GN=Svep1 PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.23349 BP_3 100.75 0.90 5666 642920507 XP_008192379.1 5378 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AVA0 1224 1.8e-132 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus GN=Svep1 PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.2335 BP_3 1940.74 82.98 1419 642914825 XP_008194954.1 1332 3.2e-144 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54315 372 2.8e-34 Inactive pancreatic lipase-related protein 1 OS=Homo sapiens GN=PNLIPRP1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23350 BP_3 187.02 1.68 5642 270006429 EFA02877.1 3449 0.0e+00 hypothetical protein TcasGA2_TC008029 [Tribolium castaneum] -- -- -- -- -- K17495 CSMD CUB and sushi domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K17495 Q4LDE5 1215 2.0e-131 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens GN=SVEP1 PE=1 SV=3 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.23352 BP_3 89.57 3.41 1557 478253719 ENN74018.1 930 1.5e-97 hypothetical protein YQE_09408, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 183 2.5e-12 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0161 Myosin class II heavy chain Cluster-8309.23354 BP_3 179.75 1.32 6831 332373456 AEE61869.1 1731 8.4e-190 unknown [Dendroctonus ponderosae]>gi|478257157|gb|ENN77320.1| hypothetical protein YQE_06146, partial [Dendroctonus ponderosae] 701345709 XM_009975740.1 83 2.25745e-32 PREDICTED: Tyto alba UDP-glucuronic acid decarboxylase 1 (LOC104368417), partial mRNA K08678 UXS1, uxs UDP-glucuronate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K08678 Q6DF08 1329 1.4e-144 UDP-glucuronic acid decarboxylase 1 OS=Xenopus tropicalis GN=uxs1 PE=2 SV=1 PF01370//PF00293//PF00106//PF01073 NAD dependent epimerase/dehydratase family//NUDIX domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0008152//GO:0008207//GO:0008209//GO:0055114//GO:0006694 estrogen metabolic process//metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0016787//GO:0003824//GO:0050662//GO:0003854//GO:0016491//GO:0016616 hydrolase activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase Cluster-8309.23358 BP_3 264.44 4.00 3480 752892475 XP_011264324.1 1492 2.2e-162 PREDICTED: POU domain, class 6, transcription factor 2 isoform X2 [Camponotus floridanus] 817056495 XM_012413689.1 172 3.83588e-82 PREDICTED: Athalia rosae POU domain, class 6, transcription factor 1 (LOC105693636), mRNA K09368 POU6F POU domain transcription factor, class 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09368 Q8BJI4 693 4.1e-71 POU domain, class 6, transcription factor 2 OS=Mus musculus GN=Pou6f2 PE=2 SV=1 PF00046//PF00157 Homeobox domain//Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.23362 BP_3 9.00 3.99 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23364 BP_3 136.00 11.34 870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702 Fibrinogen alpha/beta chain family GO:0051258//GO:0030168//GO:0007165 protein polymerization//platelet activation//signal transduction GO:0005102//GO:0030674 receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-8309.23366 BP_3 261.10 4.77 2929 546680487 ERL90753.1 1413 2.7e-153 hypothetical protein D910_08100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Z136 313 4.0e-27 Hamartin OS=Rattus norvegicus GN=Tsc1 PE=1 SV=1 PF06005//PF02465//PF11380 Protein of unknown function (DUF904)//Flagellar hook-associated protein 2 N-terminus//Stealth protein CR2, conserved region 2 GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0009424//GO:0005737 bacterial-type flagellum hook//cytoplasm KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.23367 BP_3 11.92 0.80 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23368 BP_3 11.00 0.82 940 642923667 XP_008193834.1 746 1.9e-76 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 378 3.7e-35 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF04923//PF04159//PF05656 ABC transporter transmembrane region//Ninjurin//NB glycoprotein//Protein of unknown function (DUF805) GO:0042246//GO:0006810//GO:0007155//GO:0055085 tissue regeneration//transport//cell adhesion//transmembrane transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.23369 BP_3 52.89 1.49 1999 546673062 ERL84739.1 834 2.5e-86 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 389 4.2e-36 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF01764//PF07859//PF02230//PF10503//PF11112 Lipase (class 3)//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Esterase PHB depolymerase//Pyocin activator protein PrtN GO:0006629//GO:0008152//GO:0006355 lipid metabolic process//metabolic process//regulation of transcription, DNA-templated GO:0016787 hydrolase activity GO:0005576 extracellular region KOG1552 Predicted alpha/beta hydrolase Cluster-8309.2337 BP_3 3.00 4.12 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23371 BP_3 9.00 3.52 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23373 BP_3 2.13 0.90 404 642913150 XP_008201413.1 437 5.5e-41 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09377 SBDS protein C-terminal domain GO:0042254 ribosome biogenesis -- -- -- -- -- -- Cluster-8309.23378 BP_3 129.26 3.93 1876 91078940 XP_973987.1 1302 1.3e-140 PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|642916209|ref|XP_008190931.1| PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|270003691|gb|EFA00139.1| hypothetical protein TcasGA2_TC002960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWP6 536 3.5e-53 Motile sperm domain-containing protein 2 OS=Mus musculus GN=Mospd2 PE=1 SV=2 -- -- -- -- GO:0005198 structural molecule activity -- -- KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-8309.23379 BP_3 7.06 1.48 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2338 BP_3 208.00 10.85 1216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23382 BP_3 12.82 0.44 1712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23385 BP_3 207.00 40.99 535 642915958 XP_008190827.1 447 5.1e-42 PREDICTED: probable small nuclear ribonucleoprotein E [Tribolium castaneum] 637295421 XM_003220319.2 80 7.75229e-32 PREDICTED: Anolis carolinensis small nuclear ribonucleoprotein polypeptide E (snrpe), mRNA K11097 SNRPE, SME small nuclear ribonucleoprotein E http://www.genome.jp/dbget-bin/www_bget?ko:K11097 Q9VLV5 390 8.5e-37 Probable small nuclear ribonucleoprotein E OS=Drosophila melanogaster GN=SmE PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1774 Small nuclear ribonucleoprotein E Cluster-8309.23390 BP_3 1.00 13.75 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23395 BP_3 26.05 3.44 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23396 BP_3 12.27 1.01 879 668448475 KFB38130.1 163 7.2e-09 hypothetical protein ZHAS_00005405 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23397 BP_3 84.20 0.85 5041 283046724 NP_001164308.1 1952 1.5e-215 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 751 1.1e-77 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF00023//PF13606//PF00520//PF08727 Ankyrin repeat//Ankyrin repeat//Ion transport protein//Poliovirus 3A protein like GO:0006508//GO:0006811//GO:0055085//GO:0006144 proteolysis//ion transport//transmembrane transport//purine nucleobase metabolic process GO:0005216//GO:0003968//GO:0017111//GO:0004197//GO:0005515 ion channel activity//RNA-directed RNA polymerase activity//nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//protein binding GO:0016020//GO:0031379 membrane//RNA-directed RNA polymerase complex -- -- Cluster-8309.23398 BP_3 9.03 0.34 1556 662207644 XP_008477334.1 180 1.4e-10 PREDICTED: zinc finger protein 721-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 155 4.4e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23399 BP_3 6.00 5.43 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23400 BP_3 256.65 1.57 8188 817053828 XP_012264100.1 1826 9.8e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935876 XR_511652.1 647 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X4, misc_RNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 Q9UBE8 1597 1.4e-175 Serine/threonine-protein kinase NLK OS=Homo sapiens GN=NLK PE=1 SV=2 PF04505//PF07714//PF00069//PF06293 Interferon-induced transmembrane protein//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009607//GO:0006468 response to biotic stimulus//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.23402 BP_3 7.88 0.53 1009 270002181 EEZ98628.1 244 3.3e-18 hypothetical protein TcasGA2_TC001151, partial [Tribolium castaneum] -- -- -- -- -- K18168 SDHAF2, SDH5 succinate dehydrogenase assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18168 B4GDB3 209 1.6e-15 Succinate dehydrogenase assembly factor 2-A, mitochondrial OS=Drosophila persimilis GN=GL10881 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3326 Uncharacterized conserved protein Cluster-8309.23403 BP_3 1380.00 44.13 1799 478255147 ENN75377.1 1545 8.2e-169 hypothetical protein YQE_08152, partial [Dendroctonus ponderosae]>gi|546680094|gb|ERL90435.1| hypothetical protein D910_07784 [Dendroctonus ponderosae] 723577947 XM_010310830.1 36 7.85995e-07 PREDICTED: Balearica regulorum gibbericeps membrane bound O-acyltransferase domain containing 2 (MBOAT2), partial mRNA K13517 MBOAT1_2 lysophospholipid acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13517 Q8BH98 887 6.7e-94 Lysophospholipid acyltransferase 1 OS=Mus musculus GN=Mboat1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2704 Predicted membrane protein Cluster-8309.23404 BP_3 306.00 7.94 2149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23405 BP_3 130.00 4.82 1593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23406 BP_3 191.89 2.06 4778 642930494 XP_008196427.1 2252 2.3e-250 PREDICTED: CLIP-associating protein isoform X2 [Tribolium castaneum]>gi|270009386|gb|EFA05834.1| hypothetical protein TcasGA2_TC008618 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 867 3.7e-91 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF01528//PF02985 Herpesvirus glycoprotein M//HEAT repeat -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.2341 BP_3 6.50 0.54 877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23410 BP_3 149.00 15.64 751 91078152 XP_973842.1 707 5.1e-72 PREDICTED: histone deacetylase complex subunit SAP18 [Tribolium castaneum]>gi|270001369|gb|EEZ97816.1| hypothetical protein TcasGA2_TC000183 [Tribolium castaneum] -- -- -- -- -- K14324 SAP18 histone deacetylase complex subunit SAP18 http://www.genome.jp/dbget-bin/www_bget?ko:K14324 Q9VEX9 422 2.3e-40 Histone deacetylase complex subunit SAP18 OS=Drosophila melanogaster GN=Bin1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3391 Transcriptional co-repressor component Cluster-8309.23414 BP_3 355.93 10.72 1892 642928346 XP_008195544.1 1402 3.3e-152 PREDICTED: neuronal acetylcholine receptor subunit beta-3-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02709 243 3.4e-19 Acetylcholine receptor subunit alpha OS=Bos taurus GN=CHRNA1 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.23417 BP_3 859.31 4.33 9847 642924897 XP_008194088.1 4984 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P19137 2408 1.6e-269 Laminin subunit alpha-1 OS=Mus musculus GN=Lama1 PE=1 SV=1 PF06009//PF06008 Laminin Domain II//Laminin Domain I GO:0045995//GO:0030155//GO:0030334//GO:0007155//GO:0007165 regulation of embryonic development//regulation of cell adhesion//regulation of cell migration//cell adhesion//signal transduction GO:0005102 receptor binding -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.2342 BP_3 2.00 6.98 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23421 BP_3 12.00 0.38 1832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23422 BP_3 25.32 0.52 2640 91093989 XP_970414.1 836 2.0e-86 PREDICTED: golgin-45 [Tribolium castaneum]>gi|270016104|gb|EFA12552.1| hypothetical protein TcasGA2_TC001960 [Tribolium castaneum] 801398575 XM_012204360.1 66 2.44242e-23 PREDICTED: Atta cephalotes uncharacterized LOC105622954 (LOC105622954), mRNA -- -- -- -- Q9H2G9 232 8.8e-18 Golgin-45 OS=Homo sapiens GN=BLZF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4074 Leucine zipper nuclear factor Cluster-8309.23425 BP_3 12.43 0.62 1253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23426 BP_3 245.05 3.42 3748 642921579 XP_008192431.1 1070 2.1e-113 PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum]>gi|642921581|ref|XP_008192432.1| PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum] 642921580 XM_008194210.1 260 4.98286e-131 PREDICTED: Tribolium castaneum MOB kinase activator-like 2 (LOC657020), transcript variant X2, mRNA -- -- -- -- Q2LZ59 929 1.9e-98 MOB kinase activator-like 2 OS=Drosophila pseudoobscura pseudoobscura GN=Mob1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.23427 BP_3 231.11 11.03 1302 237820629 NP_001153782.1 1172 1.1e-125 transmembrane protein 120B [Tribolium castaneum]>gi|270004540|gb|EFA00988.1| hypothetical protein TcasGA2_TC003901 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9U1M2 1013 1.2e-108 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane KOG4758 Predicted membrane protein Cluster-8309.2343 BP_3 7.00 1.13 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23433 BP_3 14.10 0.52 1603 642923229 XP_008193666.1 370 1.3e-32 PREDICTED: chromodomain-helicase-DNA-binding protein 7 isoform X2 [Tribolium castaneum] 642923230 XM_008195445.1 143 2.30831e-66 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X3, mRNA K04494 CHD8, HELSNF1 chromodomain helicase DNA binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K04494 Q9JIX5 196 8.0e-14 Chromodomain-helicase-DNA-binding protein 8 OS=Rattus norvegicus GN=Chd8 PE=1 SV=2 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0016818//GO:0005524//GO:0003676 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.23435 BP_3 67.55 4.43 1027 270003204 EEZ99651.1 607 2.7e-60 hypothetical protein TcasGA2_TC002408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G3MWR8 373 1.5e-34 Protein-methionine sulfoxide oxidase MICAL3 OS=Bos taurus GN=MICAL3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23437 BP_3 62.64 1.11 3021 642927195 XP_008195175.1 2065 7.0e-229 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75445 130 6.8e-06 Usherin OS=Homo sapiens GN=USH2A PE=1 SV=3 PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23438 BP_3 8.00 0.87 733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23439 BP_3 355.92 2.87 6273 546678097 ERL88806.1 2080 2.6e-230 hypothetical protein D910_06188 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.2344 BP_3 966.00 29.48 1871 642929332 XP_973791.2 1193 5.6e-128 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum]>gi|270010511|gb|EFA06959.1| hypothetical protein TcasGA2_TC009917 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23440 BP_3 230.01 1.30 8818 642916561 XP_008191701.1 2302 6.7e-256 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] 642916712 XM_001813000.2 329 5.18072e-169 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100141653), mRNA -- -- -- -- Q5T2T1 1155 2.8e-124 MAGUK p55 subfamily member 7 OS=Homo sapiens GN=MPP7 PE=1 SV=1 PF00651//PF14604//PF00018//PF00595//PF05225//PF13180 BTB/POZ domain//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF)//helix-turn-helix, Psq domain//PDZ domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.23441 BP_3 181.81 2.14 4378 642914301 XP_008201628.1 179 5.0e-10 PREDICTED: mediator of RNA polymerase II transcription subunit 28 isoform X1 [Tribolium castaneum] 462293333 APGK01053470.1 36 1.93408e-06 Dendroctonus ponderosae Seq01053480, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02723//PF03938//PF04037//PF06374 Non-structural protein NS3/Small envelope protein E//Outer membrane protein (OmpH-like)//Domain of unknown function (DUF382)//NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006120//GO:0006744//GO:0006814//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//proton transport GO:0051082//GO:0008137 unfolded protein binding//NADH dehydrogenase (ubiquinone) activity GO:0005743//GO:0005634//GO:0016020 mitochondrial inner membrane//nucleus//membrane -- -- Cluster-8309.23442 BP_3 306.73 6.70 2497 642915726 XP_008190777.1 1386 3.1e-150 PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum]>gi|642915728|ref|XP_008190778.1| PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 Q9NWF9 442 3.7e-42 E3 ubiquitin-protein ligase RNF216 OS=Homo sapiens GN=RNF216 PE=1 SV=3 PF03119//PF10044//PF02807 NAD-dependent DNA ligase C4 zinc finger domain//Retinal tissue protein//ATP:guanido phosphotransferase, N-terminal domain GO:0006281//GO:0006351//GO:0007049//GO:0006260 DNA repair//transcription, DNA-templated//cell cycle//DNA replication GO:0003911//GO:0016301//GO:0016772 DNA ligase (NAD+) activity//kinase activity//transferase activity, transferring phosphorus-containing groups GO:0070176 DRM complex -- -- Cluster-8309.23443 BP_3 105.00 7.45 971 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23444 BP_3 177.00 6.91 1526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23445 BP_3 18.06 0.49 2053 478270807 ENN83561.1 347 7.7e-30 hypothetical protein YQE_00084, partial [Dendroctonus ponderosae]>gi|546673459|gb|ERL85057.1| hypothetical protein D910_02480 [Dendroctonus ponderosae] -- -- -- -- -- K04450 ATF2, CREBP1 cyclic AMP-dependent transcription factor ATF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04450 P16951 136 9.3e-07 Cyclic AMP-dependent transcription factor ATF-2 OS=Mus musculus GN=Atf2 PE=1 SV=2 PF13465//PF00096//PF07716//PF00170 Zinc-finger double domain//Zinc finger, C2H2 type//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0046872 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0005667 transcription factor complex -- -- Cluster-8309.23446 BP_3 294.23 8.30 2001 91085771 XP_974257.1 513 4.2e-49 PREDICTED: cyclic AMP-dependent transcription factor ATF-7 [Tribolium castaneum]>gi|270010124|gb|EFA06572.1| hypothetical protein TcasGA2_TC009483 [Tribolium castaneum] -- -- -- -- -- K04450 ATF2, CREBP1 cyclic AMP-dependent transcription factor ATF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04450 P16951 242 4.6e-19 Cyclic AMP-dependent transcription factor ATF-2 OS=Mus musculus GN=Atf2 PE=1 SV=2 PF00096//PF07716//PF00170 Zinc finger, C2H2 type//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0046872//GO:0003700 sequence-specific DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.23448 BP_3 51.32 0.95 2891 270003696 EFA00144.1 2102 3.4e-233 hypothetical protein TcasGA2_TC002965 [Tribolium castaneum] 746862194 XM_011063702.1 155 8.96717e-73 PREDICTED: Acromyrmex echinatior uncharacterized LOC105150543 (LOC105150543), mRNA K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q8VHQ2 432 6.2e-41 Suppressor of cytokine signaling 7 OS=Mus musculus GN=Socs7 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.23449 BP_3 855.07 64.07 935 332373446 AEE61864.1 813 3.2e-84 unknown [Dendroctonus ponderosae]>gi|478251984|gb|ENN72420.1| hypothetical protein YQE_10938, partial [Dendroctonus ponderosae]>gi|546677825|gb|ERL88582.1| hypothetical protein D910_05967 [Dendroctonus ponderosae] 571553273 XM_001119998.3 173 2.79191e-83 PREDICTED: Apis mellifera probable N-acetyltransferase san-like (LOC724486), mRNA -- -- -- -- Q9NHD5 717 1.8e-74 Probable N-acetyltransferase san OS=Drosophila melanogaster GN=san PE=1 SV=1 PF00583//PF13508//PF08445//PF13302//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- KOG3138 Predicted N-acetyltransferase Cluster-8309.2345 BP_3 808.00 35.85 1378 478258007 ENN78145.1 871 9.0e-91 hypothetical protein YQE_05299, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05307//PF01758 Bundlin//Sodium Bile acid symporter family -- -- -- -- GO:0016020//GO:0009289 membrane//pilus -- -- Cluster-8309.23451 BP_3 9.17 0.48 1222 642911921 XP_008199023.1 410 2.3e-37 PREDICTED: casein kinase I isoform gamma-3-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q4R9A9 362 3.4e-33 Casein kinase I isoform gamma-1 OS=Macaca fascicularis GN=CSNK1G1 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.23453 BP_3 2050.82 22.89 4610 642912808 XP_008201260.1 1904 5.0e-210 PREDICTED: neurogenic protein mastermind-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21519 206 1.6e-14 Neurogenic protein mastermind OS=Drosophila melanogaster GN=mam PE=2 SV=2 PF09596 MamL-1 domain GO:0007219//GO:0045944 Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter GO:0003713 transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex -- -- Cluster-8309.23454 BP_3 633.52 13.26 2594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23455 BP_3 17.97 0.37 2611 270004760 EFA01208.1 211 5.8e-14 hypothetical protein TcasGA2_TC010535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23456 BP_3 57.31 2.01 1669 478261323 ENN80739.1 1196 2.2e-128 hypothetical protein YQE_02847, partial [Dendroctonus ponderosae]>gi|546680358|gb|ERL90637.1| hypothetical protein D910_07984 [Dendroctonus ponderosae] -- -- -- -- -- K19373 DNAJC28 DnaJ homolog subfamily C member 28 http://www.genome.jp/dbget-bin/www_bget?ko:K19373 Q9NX36 571 2.7e-57 DnaJ homolog subfamily C member 28 OS=Homo sapiens GN=DNAJC28 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0568 Molecular chaperone (DnaJ superfamily) Cluster-8309.23457 BP_3 110.89 3.33 1898 478261323 ENN80739.1 1196 2.6e-128 hypothetical protein YQE_02847, partial [Dendroctonus ponderosae]>gi|546680358|gb|ERL90637.1| hypothetical protein D910_07984 [Dendroctonus ponderosae] -- -- -- -- -- K19373 DNAJC28 DnaJ homolog subfamily C member 28 http://www.genome.jp/dbget-bin/www_bget?ko:K19373 Q9NX36 571 3.1e-57 DnaJ homolog subfamily C member 28 OS=Homo sapiens GN=DNAJC28 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0568 Molecular chaperone (DnaJ superfamily) Cluster-8309.23458 BP_3 7.00 0.50 968 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23459 BP_3 22.53 0.87 1534 270004129 EFA00577.1 932 8.5e-98 hypothetical protein TcasGA2_TC003447 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q8TEB1 682 3.4e-70 DDB1- and CUL4-associated factor 11 OS=Homo sapiens GN=DCAF11 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.23462 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23464 BP_3 249.00 5.00 2692 189236918 XP_969975.2 1307 4.9e-141 PREDICTED: pantothenate kinase 4 [Tribolium castaneum]>gi|270007346|gb|EFA03794.1| hypothetical protein TcasGA2_TC013906 [Tribolium castaneum] -- -- -- -- -- K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q4R4U1 765 1.4e-79 Pantothenate kinase 4 OS=Macaca fascicularis GN=PANK4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4584 Uncharacterized conserved protein Cluster-8309.23465 BP_3 212.00 9.67 1348 642927818 XP_008195414.1 1317 1.7e-142 PREDICTED: zinc finger FYVE domain-containing protein 19 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96K21 242 3.1e-19 Abscission/NoCut checkpoint regulator OS=Homo sapiens GN=ZFYVE19 PE=1 SV=3 PF00643//PF01363 B-box zinc finger//FYVE zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.23468 BP_3 36.42 1.36 1581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23470 BP_3 13.00 0.50 1540 780632583 XP_011685835.1 629 1.2e-62 PREDICTED: regucalcin-like isoform X1 [Wasmannia auropunctata] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6DF62 396 5.0e-37 Regucalcin OS=Xenopus tropicalis GN=rgn PE=2 SV=1 PF01731 Arylesterase -- -- GO:0004064 arylesterase activity -- -- -- -- Cluster-8309.23471 BP_3 297.55 8.62 1955 642938910 XP_008195559.1 1440 1.3e-156 PREDICTED: DENN domain-containing protein 1B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 410 1.5e-38 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.23472 BP_3 577.37 6.21 4776 91094007 XP_971310.1 2349 1.3e-261 PREDICTED: DENN domain-containing protein 1A isoform X1 [Tribolium castaneum]>gi|270016162|gb|EFA12610.1| hypothetical protein TcasGA2_TC006851 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 948 1.5e-100 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.23473 BP_3 26.11 0.79 1876 642918767 XP_008191575.1 1235 7.6e-133 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9Y251 732 6.6e-76 Heparanase OS=Homo sapiens GN=HPSE PE=1 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.23474 BP_3 21.34 0.76 1642 642918767 XP_008191575.1 728 4.1e-74 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9Y251 380 3.8e-35 Heparanase OS=Homo sapiens GN=HPSE PE=1 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.23476 BP_3 6.32 0.34 1181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23478 BP_3 10.67 0.46 1408 642935999 XP_973446.3 337 7.7e-29 PREDICTED: uncharacterized protein YJR142W [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47173 155 4.0e-09 Uncharacterized protein YJR142W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YJR142W PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4313 Thiamine pyrophosphokinase Cluster-8309.23480 BP_3 5.07 0.78 607 642931995 XP_008196812.1 282 7.9e-23 PREDICTED: splicing factor U2AF 50 kDa subunit [Tribolium castaneum]>gi|270011684|gb|EFA08132.1| hypothetical protein TcasGA2_TC005736 [Tribolium castaneum] 642931994 XM_008198590.1 63 2.50032e-22 PREDICTED: Tribolium castaneum splicing factor U2AF 50 kDa subunit (LOC663317), mRNA K12837 U2AF2 splicing factor U2AF 65 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12837 Q24562 218 8.5e-17 Splicing factor U2AF 50 kDa subunit OS=Drosophila melanogaster GN=U2af50 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0120 Splicing factor U2AF, large subunit (RRM superfamily) Cluster-8309.23482 BP_3 116.61 10.66 819 642931995 XP_008196812.1 851 1.1e-88 PREDICTED: splicing factor U2AF 50 kDa subunit [Tribolium castaneum]>gi|270011684|gb|EFA08132.1| hypothetical protein TcasGA2_TC005736 [Tribolium castaneum] 642931994 XM_008198590.1 264 6.30123e-134 PREDICTED: Tribolium castaneum splicing factor U2AF 50 kDa subunit (LOC663317), mRNA K12837 U2AF2 splicing factor U2AF 65 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12837 Q24562 724 2.4e-75 Splicing factor U2AF 50 kDa subunit OS=Drosophila melanogaster GN=U2af50 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006397 mRNA processing GO:0000166//GO:0003723//GO:0003676 nucleotide binding//RNA binding//nucleic acid binding GO:0005634 nucleus KOG0120 Splicing factor U2AF, large subunit (RRM superfamily) Cluster-8309.23483 BP_3 7.83 0.45 1133 91089925 XP_972979.1 1311 7.0e-142 PREDICTED: target of rapamycin complex subunit lst8 [Tribolium castaneum] -- -- -- -- -- K08266 GBL G protein beta subunit-like http://www.genome.jp/dbget-bin/www_bget?ko:K08266 Q803V5 1066 7.4e-115 Target of rapamycin complex subunit lst8 OS=Danio rerio GN=mlst8 PE=2 SV=1 PF00400//PF02897 WD domain, G-beta repeat//Prolyl oligopeptidase, N-terminal beta-propeller domain -- -- GO:0070008//GO:0004252//GO:0005515 serine-type exopeptidase activity//serine-type endopeptidase activity//protein binding -- -- KOG0315 G-protein beta subunit-like protein (contains WD40 repeats) Cluster-8309.23484 BP_3 223.00 17.36 911 189239493 XP_975507.2 473 8.4e-45 PREDICTED: ribosomal RNA processing protein 36 homolog [Tribolium castaneum]>gi|270009556|gb|EFA06004.1| hypothetical protein TcasGA2_TC008830 [Tribolium castaneum] -- -- -- -- -- K14795 RRP36 ribosomal RNA-processing protein 36 http://www.genome.jp/dbget-bin/www_bget?ko:K14795 A7SL20 256 5.0e-21 Ribosomal RNA processing protein 36 homolog OS=Nematostella vectensis GN=v1g245966 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3190 Uncharacterized conserved protein Cluster-8309.23486 BP_3 321.00 9.53 1916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01741 Large-conductance mechanosensitive channel, MscL GO:0006810//GO:0006811 transport//ion transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.23489 BP_3 25.06 0.69 2049 189240742 XP_001808055.1 404 1.9e-36 PREDICTED: acylphosphatase-2-like isoform X3 [Tribolium castaneum]>gi|642934133|ref|XP_008199290.1| PREDICTED: acylphosphatase-2-like isoform X3 [Tribolium castaneum]>gi|270012910|gb|EFA09358.1| hypothetical protein TcasGA2_TC001919 [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 P24540 230 1.2e-17 Acylphosphatase-1 OS=Sus scrofa GN=ACYP1 PE=1 SV=2 PF08718 Glycolipid transfer protein (GLTP) GO:0018874//GO:0006096//GO:0046836//GO:0006094 benzoate metabolic process//glycolytic process//glycolipid transport//gluconeogenesis GO:0017089//GO:0051861//GO:0003998 glycolipid transporter activity//glycolipid binding//acylphosphatase activity GO:0005737 cytoplasm -- -- Cluster-8309.23492 BP_3 52.13 1.64 1820 91077854 XP_972003.1 2194 4.6e-244 PREDICTED: tetratricopeptide repeat protein 7B [Tribolium castaneum]>gi|270002262|gb|EEZ98709.1| hypothetical protein TcasGA2_TC001250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86TV6 821 3.1e-86 Tetratricopeptide repeat protein 7B OS=Homo sapiens GN=TTC7B PE=1 SV=3 PF00515//PF13181//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG4162 Predicted calmodulin-binding protein Cluster-8309.23495 BP_3 452.74 11.39 2208 91077058 XP_968505.1 2308 3.4e-257 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] 665802087 XM_008550863.1 127 2.50819e-57 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 Q0V7M0 1916 4.0e-213 Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1 PF00514//PF11698//PF01602//PF02985//PF16006//PF10508//PF01749 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region//HEAT repeat//Nucleolar and spindle-associated protein//Proteasome non-ATPase 26S subunit//Importin beta binding domain GO:0000281//GO:0000226//GO:0015991//GO:0040001//GO:0015031//GO:0006606//GO:0043248//GO:0006886//GO:0016192 mitotic cytokinesis//microtubule cytoskeleton organization//ATP hydrolysis coupled proton transport//establishment of mitotic spindle localization//protein transport//protein import into nucleus//proteasome assembly//intracellular protein transport//vesicle-mediated transport GO:0016820//GO:0005515//GO:0008565 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//protein transporter activity GO:0030117//GO:0005819//GO:0000221//GO:0005874//GO:0005634//GO:0005737 membrane coat//spindle//vacuolar proton-transporting V-type ATPase, V1 domain//microtubule//nucleus//cytoplasm KOG0166 Karyopherin (importin) alpha Cluster-8309.235 BP_3 2.00 0.34 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2350 BP_3 6.64 0.74 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23501 BP_3 37.88 0.77 2650 332030242 EGI70025.1 2730 4.7e-306 Kelch-like protein diablo [Acromyrmex echinatior] 642921871 XM_961984.3 369 0 PREDICTED: Tribolium castaneum kelch-like protein diablo (LOC655440), mRNA K10457 KLHL20, KLEIP kelch-like protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10457 Q16RL8 2335 1.2e-261 Kelch-like protein diablo OS=Aedes aegypti GN=dbo PE=3 SV=1 PF07646//PF00651//PF01344 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.23502 BP_3 16.86 0.48 1973 189237009 XP_967077.2 2584 3.0e-289 PREDICTED: kelch-like protein diablo [Tribolium castaneum]>gi|270007324|gb|EFA03772.1| hypothetical protein TcasGA2_TC013883 [Tribolium castaneum] 642921871 XM_961984.3 460 0 PREDICTED: Tribolium castaneum kelch-like protein diablo (LOC655440), mRNA K10457 KLHL20, KLEIP kelch-like protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10457 Q16RL8 2470 2.0e-277 Kelch-like protein diablo OS=Aedes aegypti GN=dbo PE=3 SV=1 PF00651//PF07646//PF01344 BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.23503 BP_3 395.29 10.37 2129 189237009 XP_967077.2 2584 3.2e-289 PREDICTED: kelch-like protein diablo [Tribolium castaneum]>gi|270007324|gb|EFA03772.1| hypothetical protein TcasGA2_TC013883 [Tribolium castaneum] 642921871 XM_961984.3 459 0 PREDICTED: Tribolium castaneum kelch-like protein diablo (LOC655440), mRNA K10457 KLHL20, KLEIP kelch-like protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10457 Q16RL8 2470 2.2e-277 Kelch-like protein diablo OS=Aedes aegypti GN=dbo PE=3 SV=1 PF01344//PF00651//PF07646 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.23506 BP_3 136.00 6.74 1265 478250790 ENN71282.1 700 5.6e-71 hypothetical protein YQE_12207, partial [Dendroctonus ponderosae]>gi|546673012|gb|ERL84698.1| hypothetical protein D910_02123 [Dendroctonus ponderosae] -- -- -- -- -- K03681 RRP40, EXOSC3 exosome complex component RRP40 http://www.genome.jp/dbget-bin/www_bget?ko:K03681 Q3T0E1 368 7.2e-34 Exosome complex component RRP40 OS=Bos taurus GN=EXOSC3 PE=2 SV=1 PF15985//PF00575 KH domain//S1 RNA binding domain -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG1004 Exosomal 3'-5' exoribonuclease complex subunit Rrp40 Cluster-8309.23508 BP_3 36.46 0.83 2413 642929118 XP_008195696.1 698 1.8e-70 PREDICTED: uncharacterized protein LOC100142378 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42892 467 4.5e-45 Endothelin-converting enzyme 1 OS=Homo sapiens GN=ECE1 PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.23509 BP_3 56.38 0.80 3692 270012487 EFA08935.1 2481 4.9e-277 hypothetical protein TcasGA2_TC006642 [Tribolium castaneum] 645037466 XM_008219044.1 217 3.93048e-107 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1544 9.1e-170 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF02214//PF00520 BTB/POZ domain//Ion transport protein GO:0055085//GO:0006811//GO:0051260 transmembrane transport//ion transport//protein homooligomerization GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.2351 BP_3 67.00 8.36 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23511 BP_3 12.49 0.70 1149 861635019 KMQ91440.1 924 5.3e-97 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] 752860622 XM_011254593.1 184 2.65207e-89 PREDICTED: Camponotus floridanus putative uncharacterized protein FLJ37770 (LOC105249263), mRNA -- -- -- -- Q7JQ07 297 1.1e-25 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.23512 BP_3 26.67 0.69 2152 642937472 XP_008198851.1 354 1.3e-30 PREDICTED: protein tramtrack, beta isoform-like isoform X13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23513 BP_3 338.26 2.95 5820 478253875 ENN74167.1 2111 6.2e-234 hypothetical protein YQE_09140, partial [Dendroctonus ponderosae] 642911731 XM_008202495.1 40 1.53966e-08 PREDICTED: Tribolium castaneum uncharacterized LOC660279 (LOC660279), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23515 BP_3 21.78 0.84 1541 642914631 XP_008190292.1 980 2.3e-103 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0016787//GO:0003676//GO:0046872 hydrolase activity//nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.23521 BP_3 125.47 8.42 1010 642935674 XP_974741.2 521 2.5e-50 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9S1 415 2.0e-39 Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Drosophila melanogaster GN=blos1 PE=1 SV=2 PF06151//PF06320 Trehalose receptor//GCN5-like protein 1 (GCN5L1) GO:0007607//GO:0007187//GO:0050912 obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste GO:0008527 taste receptor activity GO:0031083//GO:0016021 BLOC-1 complex//integral component of membrane KOG3390 General control of amino-acid synthesis 5-like 1 Cluster-8309.23525 BP_3 51.64 1.44 2022 91076754 XP_973519.1 1366 5.3e-148 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63564 356 2.8e-32 Synaptic vesicle glycoprotein 2B OS=Rattus norvegicus GN=Sv2b PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.23526 BP_3 122.15 2.11 3086 642939345 XP_008197083.1 1546 1.1e-168 PREDICTED: uncharacterized protein LOC103314054 [Tribolium castaneum] -- -- -- -- -- K09453 SNAPC4 snRNA-activating protein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09453 Q5SXM2 386 1.4e-35 snRNA-activating protein complex subunit 4 OS=Homo sapiens GN=SNAPC4 PE=1 SV=1 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0016818//GO:0005524//GO:0003676 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//nucleic acid binding GO:0005634 nucleus KOG0049 Transcription factor, Myb superfamily Cluster-8309.23527 BP_3 43.37 0.72 3204 270016448 EFA12894.1 1488 6.0e-162 hypothetical protein TcasGA2_TC004408 [Tribolium castaneum] -- -- -- -- -- K09453 SNAPC4 snRNA-activating protein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09453 Q5SXM2 383 3.3e-35 snRNA-activating protein complex subunit 4 OS=Homo sapiens GN=SNAPC4 PE=1 SV=1 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0003676//GO:0005524//GO:0016818 nucleic acid binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0049 Transcription factor, Myb superfamily Cluster-8309.23528 BP_3 60.36 0.98 3271 642939345 XP_008197083.1 1257 3.7e-135 PREDICTED: uncharacterized protein LOC103314054 [Tribolium castaneum] -- -- -- -- -- K09453 SNAPC4 snRNA-activating protein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09453 Q5SXM2 383 3.4e-35 snRNA-activating protein complex subunit 4 OS=Homo sapiens GN=SNAPC4 PE=1 SV=1 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0005524//GO:0003676//GO:0016818 ATP binding//nucleic acid binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0049 Transcription factor, Myb superfamily Cluster-8309.23534 BP_3 48.71 0.40 6178 91076220 XP_972698.1 2848 0.0e+00 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum]>gi|270014737|gb|EFA11185.1| hypothetical protein TcasGA2_TC004793 [Tribolium castaneum] 462373375 APGK01024771.1 212 3.97405e-104 Dendroctonus ponderosae Seq01024781, whole genome shotgun sequence K14353 SLCO3A solute carrier organic anion transporter family, member 3A http://www.genome.jp/dbget-bin/www_bget?ko:K14353 Q9H2Y9 884 5.2e-93 Solute carrier organic anion transporter family member 5A1 OS=Homo sapiens GN=SLCO5A1 PE=2 SV=2 PF07690//PF03137//PF07648//PF00050 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0055085//GO:0006810 transmembrane transport//transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.23538 BP_3 222.49 2.51 4572 546682287 ERL92245.1 3267 0.0e+00 hypothetical protein D910_09562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2073 5.1e-231 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF01926//PF00664//PF00437//PF03193//PF00005//PF06414//PF07840//PF00931 AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter//Zeta toxin//FadR C-terminal domain//NB-ARC domain GO:0019217//GO:0055085//GO:0006810 regulation of fatty acid metabolic process//transmembrane transport//transport GO:0005524//GO:0000062//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626 ATP binding//fatty-acyl-CoA binding//ADP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.23540 BP_3 95.51 0.94 5188 546682287 ERL92245.1 3267 0.0e+00 hypothetical protein D910_09562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2073 5.8e-231 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF06414//PF07840//PF03193//PF00005//PF00437//PF01926//PF13304//PF00664 NB-ARC domain//Zeta toxin//FadR C-terminal domain//Protein of unknown function, DUF258//ABC transporter//Type II/IV secretion system protein//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0019217//GO:0055085//GO:0006810 regulation of fatty acid metabolic process//transmembrane transport//transport GO:0005525//GO:0016301//GO:0016887//GO:0042626//GO:0005524//GO:0000062//GO:0043531//GO:0003924 GTP binding//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//fatty-acyl-CoA binding//ADP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.23541 BP_3 52.00 0.77 3539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00170//PF13397 bZIP transcription factor//RNA polymerase-binding protein GO:0045893//GO:0006355 positive regulation of transcription, DNA-templated//regulation of transcription, DNA-templated GO:0003700//GO:0001000//GO:0043565 transcription factor activity, sequence-specific DNA binding//bacterial-type RNA polymerase core enzyme binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.23542 BP_3 316.78 7.46 2339 642915126 XP_008190421.1 935 5.8e-98 PREDICTED: polynucleotide 5'-hydroxyl-kinase NOL9 [Tribolium castaneum] -- -- -- -- -- K06947 GRC3, NOL9 polynucleotide 5'-hydroxyl-kinase GRC3/NOL9 http://www.genome.jp/dbget-bin/www_bget?ko:K06947 A1ZA92 411 1.4e-38 Polynucleotide 5'-hydroxyl-kinase NOL9 OS=Drosophila melanogaster GN=CG8414 PE=2 SV=1 PF00005//PF01580 ABC transporter//FtsK/SpoIIIE family -- -- GO:0005524//GO:0000166//GO:0003677//GO:0016887 ATP binding//nucleotide binding//DNA binding//ATPase activity -- -- KOG2750 Uncharacterized conserved protein similar to ATP/GTP-binding protein Cluster-8309.23543 BP_3 11.00 5.73 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23544 BP_3 28.89 0.42 3646 189239183 XP_966847.2 1514 6.6e-165 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q7KT91 942 5.7e-100 Non-lysosomal glucosylceramidase OS=Drosophila melanogaster GN=CG33090 PE=1 SV=1 PF01232//PF04685 Mannitol dehydrogenase Rossmann domain//Protein of unknown function, DUF608 GO:0006687//GO:0005975//GO:0006680//GO:0006807//GO:0055114//GO:0006665 glycosphingolipid metabolic process//carbohydrate metabolic process//glucosylceramide catabolic process//nitrogen compound metabolic process//oxidation-reduction process//sphingolipid metabolic process GO:0004348//GO:0016491 glucosylceramidase activity//oxidoreductase activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.23546 BP_3 54.28 0.87 3310 546679741 ERL90152.1 1446 4.6e-157 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96RT8 301 1.1e-25 Gamma-tubulin complex component 5 OS=Homo sapiens GN=TUBGCP5 PE=1 SV=1 PF04130//PF01222 Spc97 / Spc98 family//Ergosterol biosynthesis ERG4/ERG24 family GO:0000226//GO:0090063 microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0000922//GO:0016020//GO:0005815 spindle pole//membrane//microtubule organizing center -- -- Cluster-8309.23547 BP_3 47.00 3.34 970 321479310 EFX90266.1 1038 2.7e-110 hypothetical protein DAPPUDRAFT_299917 [Daphnia pulex] 262401288 FJ774826.1 537 0 Scylla paramamosain ribosomal protein L5 mRNA, partial cds K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 P15126 995 1.1e-106 60S ribosomal protein L5-B OS=Xenopus laevis GN=rpl5-b PE=2 SV=2 PF00861 Ribosomal L18p/L5e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0875 60S ribosomal protein L5 Cluster-8309.23548 BP_3 6.00 0.35 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23549 BP_3 42.31 1.33 1820 642911217 XP_008199631.1 1154 1.8e-123 PREDICTED: FCH domain only protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UQN2 644 1.0e-65 F-BAR domain only protein 2 OS=Mus musculus GN=Fcho2 PE=1 SV=1 PF02662 Methyl-viologen-reducing hydrogenase, delta subunit GO:0055114//GO:0015948 oxidation-reduction process//methanogenesis -- -- -- -- KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.23550 BP_3 8.11 0.43 1208 642918514 XP_008191505.1 183 4.7e-11 PREDICTED: zinc finger protein Xfin-like [Tribolium castaneum]>gi|270003216|gb|EEZ99663.1| hypothetical protein TcasGA2_TC002420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23551 BP_3 107.00 5.93 1161 659099915 AID60336.1 629 8.7e-63 trypsin-2 [Nilaparvata lugens]>gi|659100019|gb|AID60340.1| trypsin-6 [Nilaparvata lugens] 564266055 XM_006271792.1 35 1.8045e-06 PREDICTED: Alligator mississippiensis cationic trypsin-3-like (LOC102568334), mRNA -- -- -- -- Q05319 481 5.2e-47 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23553 BP_3 139.05 4.36 1830 91084337 XP_972793.1 832 4.0e-86 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 3.39418e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 542 6.9e-54 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 -- -- -- -- GO:0005515 protein binding -- -- KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.23554 BP_3 4.00 0.69 571 170070943 XP_001869764.1 136 6.3e-06 ion channel nompc [Culex quinquefasciatus]>gi|167866876|gb|EDS30259.1| ion channel nompc [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23557 BP_3 622.48 5.77 5490 478251983 ENN72419.1 2437 9.3e-272 hypothetical protein YQE_10937, partial [Dendroctonus ponderosae]>gi|546677824|gb|ERL88581.1| hypothetical protein D910_05966 [Dendroctonus ponderosae] 571553273 XM_001119998.3 173 1.68896e-82 PREDICTED: Apis mellifera probable N-acetyltransferase san-like (LOC724486), mRNA K07188 LIPE, HSL hormone-sensitive lipase http://www.genome.jp/dbget-bin/www_bget?ko:K07188 Q68J42 803 1.1e-83 Hormone-sensitive lipase OS=Sus scrofa GN=LIPE PE=2 SV=1 PF06350//PF07859//PF13508//PF00583//PF13673//PF13302//PF08445 Hormone-sensitive lipase (HSL) N-terminus//alpha/beta hydrolase fold//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein GO:0016042//GO:0008203//GO:0042967//GO:0008152 lipid catabolic process//cholesterol metabolic process//acyl-carrier-protein biosynthetic process//metabolic process GO:0016747//GO:0016298//GO:0008080//GO:0016787 transferase activity, transferring acyl groups other than amino-acyl groups//lipase activity//N-acetyltransferase activity//hydrolase activity -- -- KOG3138 Predicted N-acetyltransferase Cluster-8309.23559 BP_3 8.42 0.49 1124 332373446 AEE61864.1 527 5.7e-51 unknown [Dendroctonus ponderosae]>gi|478251984|gb|ENN72420.1| hypothetical protein YQE_10938, partial [Dendroctonus ponderosae]>gi|546677825|gb|ERL88582.1| hypothetical protein D910_05967 [Dendroctonus ponderosae] 805767100 XM_003701018.2 91 1.29465e-37 PREDICTED: Megachile rotundata probable N-acetyltransferase san (LOC100882765), mRNA -- -- -- -- Q9NHD5 478 1.1e-46 Probable N-acetyltransferase san OS=Drosophila melanogaster GN=san PE=1 SV=1 PF13673//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3138 Predicted N-acetyltransferase Cluster-8309.2356 BP_3 6.16 0.31 1249 817212892 XP_012282645.1 255 2.2e-19 PREDICTED: pyridoxine-5'-phosphate oxidase-like isoform X2 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04420 CHD5-like protein GO:0071816 tail-anchored membrane protein insertion into ER membrane -- -- -- -- -- -- Cluster-8309.23563 BP_3 254.57 2.12 6077 642936624 XP_008198511.1 3141 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.42689e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 8.3e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF01166//PF02346 TSC-22/dip/bun family//Chordopoxvirus multifunctional envelope protein A27 GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.23564 BP_3 444.35 15.02 1718 549438539 AGX25158.1 707 1.2e-71 windbeutel-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K09586 ERP29 endoplasmic reticulum protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K09586 O44342 341 1.3e-30 Protein windbeutel OS=Drosophila melanogaster GN=wbl PE=1 SV=1 PF07749//PF07912 Endoplasmic reticulum protein ERp29, C-terminal domain//ERp29, N-terminal domain GO:0009306 protein secretion -- -- GO:0005788//GO:0005783 endoplasmic reticulum lumen//endoplasmic reticulum -- -- Cluster-8309.23565 BP_3 260.05 5.56 2546 91079766 XP_966799.1 1315 5.4e-142 PREDICTED: protein claret segregational [Tribolium castaneum]>gi|270003319|gb|EEZ99766.1| hypothetical protein TcasGA2_TC002539 [Tribolium castaneum] -- -- -- -- -- K10405 KIFC1 kinesin family member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K10405 P20480 987 2.4e-105 Protein claret segregational OS=Drosophila melanogaster GN=ncd PE=1 SV=1 PF04192//PF06156//PF06005//PF05524//PF16796//PF00225//PF09728//PF01087//PF01166//PF08653//PF02183 Utp21 specific WD40 associated putative domain//Protein of unknown function (DUF972)//Protein of unknown function (DUF904)//PEP-utilising enzyme, N-terminal//Microtubule binding//Kinesin motor domain//Myosin-like coiled-coil protein//Galactose-1-phosphate uridyl transferase, N-terminal domain//TSC-22/dip/bun family//DASH complex subunit Dam1//Homeobox associated leucine zipper GO:0006364//GO:0009401//GO:0006260//GO:0008608//GO:0007017//GO:0006355//GO:0009117//GO:0007018//GO:0000917//GO:0043093//GO:0006012 rRNA processing//phosphoenolpyruvate-dependent sugar phosphotransferase system//DNA replication//attachment of spindle microtubules to kinetochore//microtubule-based process//regulation of transcription, DNA-templated//nucleotide metabolic process//microtubule-based movement//barrier septum assembly//FtsZ-dependent cytokinesis//galactose metabolic process GO:0008108//GO:0003700//GO:0043565//GO:0005524//GO:0008017//GO:0003777//GO:0019905 UDP-glucose:hexose-1-phosphate uridylyltransferase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//ATP binding//microtubule binding//microtubule motor activity//syntaxin binding GO:0032040//GO:0005737//GO:0042729//GO:0045298//GO:0005667//GO:0005874//GO:0072686 small-subunit processome//cytoplasm//DASH complex//tubulin complex//transcription factor complex//microtubule//mitotic spindle KOG0239 Kinesin (KAR3 subfamily) Cluster-8309.23566 BP_3 158.95 3.58 2431 91079766 XP_966799.1 1315 5.2e-142 PREDICTED: protein claret segregational [Tribolium castaneum]>gi|270003319|gb|EEZ99766.1| hypothetical protein TcasGA2_TC002539 [Tribolium castaneum] -- -- -- -- -- K10405 KIFC1 kinesin family member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K10405 P20480 987 2.3e-105 Protein claret segregational OS=Drosophila melanogaster GN=ncd PE=1 SV=1 PF04192//PF04111//PF06156//PF06005//PF05524//PF16796//PF09728//PF00225//PF01087//PF01166//PF08653//PF02183 Utp21 specific WD40 associated putative domain//Autophagy protein Apg6//Protein of unknown function (DUF972)//Protein of unknown function (DUF904)//PEP-utilising enzyme, N-terminal//Microtubule binding//Myosin-like coiled-coil protein//Kinesin motor domain//Galactose-1-phosphate uridyl transferase, N-terminal domain//TSC-22/dip/bun family//DASH complex subunit Dam1//Homeobox associated leucine zipper GO:0006012//GO:0043093//GO:0000917//GO:0007018//GO:0009117//GO:0006914//GO:0006260//GO:0009401//GO:0006364//GO:0007017//GO:0006355//GO:0008608 galactose metabolic process//FtsZ-dependent cytokinesis//barrier septum assembly//microtubule-based movement//nucleotide metabolic process//autophagy//DNA replication//phosphoenolpyruvate-dependent sugar phosphotransferase system//rRNA processing//microtubule-based process//regulation of transcription, DNA-templated//attachment of spindle microtubules to kinetochore GO:0003777//GO:0019905//GO:0008017//GO:0005524//GO:0043565//GO:0003700//GO:0008108 microtubule motor activity//syntaxin binding//microtubule binding//ATP binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0072686//GO:0005874//GO:0005667//GO:0045298//GO:0042729//GO:0032040//GO:0005737 mitotic spindle//microtubule//transcription factor complex//tubulin complex//DASH complex//small-subunit processome//cytoplasm KOG0239 Kinesin (KAR3 subfamily) Cluster-8309.23568 BP_3 166.61 1.68 5069 478256706 ENN76888.1 3154 0.0e+00 hypothetical protein YQE_06729, partial [Dendroctonus ponderosae]>gi|546685096|gb|ERL94623.1| hypothetical protein D910_11899 [Dendroctonus ponderosae] 642938565 XM_008201622.1 70 2.81914e-25 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X7, mRNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 4.2e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF09258 Glycosyl transferase family 64 domain GO:0006024//GO:0015012 glycosaminoglycan biosynthetic process//heparan sulfate proteoglycan biosynthetic process -- -- GO:0016021 integral component of membrane KOG1021 Acetylglucosaminyltransferase EXT1/exostosin 1 Cluster-8309.23569 BP_3 23.04 0.91 1512 270004583 EFA01031.1 541 1.8e-52 hypothetical protein TcasGA2_TC003947 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P35789 481 6.8e-47 Zinc finger protein 93 OS=Homo sapiens GN=ZNF93 PE=2 SV=4 PF01258//PF13912//PF13465//PF00096 Prokaryotic dksA/traR C4-type zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.23570 BP_3 453.61 9.11 2692 189240191 XP_001815657.1 2752 1.3e-308 PREDICTED: uncharacterized protein LOC100142139 [Tribolium castaneum] 642932121 XM_001815605.2 498 0 PREDICTED: Tribolium castaneum uncharacterized LOC100142139 (LOC100142139), mRNA -- -- -- -- Q18PE1 413 9.3e-39 Protein Dok-7 OS=Homo sapiens GN=DOK7 PE=1 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.23572 BP_3 2331.08 21.40 5542 642937261 XP_008198761.1 2847 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270001290|gb|EEZ97737.1| tartan/capricious-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70389 441 1.1e-41 Insulin-like growth factor-binding protein complex acid labile subunit OS=Mus musculus GN=Igfals PE=2 SV=1 PF13855//PF00560//PF01299//PF01080 Leucine rich repeat//Leucine Rich Repeat//Lysosome-associated membrane glycoprotein (Lamp)//Presenilin -- -- GO:0005515//GO:0004190 protein binding//aspartic-type endopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.23573 BP_3 35.00 1.35 1540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23574 BP_3 10.49 0.32 1890 827550232 XP_012547131.1 286 8.4e-23 PREDICTED: uncharacterized protein LOC101740234 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23575 BP_3 197.61 7.47 1567 642935999 XP_973446.3 1347 6.5e-146 PREDICTED: uncharacterized protein YJR142W [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47173 436 1.2e-41 Uncharacterized protein YJR142W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YJR142W PE=1 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4313 Thiamine pyrophosphokinase Cluster-8309.23582 BP_3 2.00 0.57 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23583 BP_3 9.19 0.37 1504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006813//GO:0006814 potassium ion transport//sodium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.23589 BP_3 28.08 0.56 2701 642924494 XP_008194318.1 1947 3.0e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 6.8e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.2359 BP_3 1.00 1.27 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23590 BP_3 1.00 0.78 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23592 BP_3 92.05 1.66 2971 642928510 XP_008193821.1 3134 0.0e+00 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X2 [Tribolium castaneum] 755894366 XM_011297040.1 39 2.80997e-08 PREDICTED: Musca domestica multiple C2 and transmembrane domain-containing protein 1 (LOC101898395), transcript variant X1, mRNA -- -- -- -- Q6DN14 1246 2.6e-135 Multiple C2 and transmembrane domain-containing protein 1 OS=Homo sapiens GN=MCTP1 PE=2 SV=2 PF00168//PF00606 C2 domain//Herpesvirus Glycoprotein B -- -- GO:0005515 protein binding GO:0016020 membrane KOG1030 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.23593 BP_3 52.74 0.65 4177 642928510 XP_008193821.1 3443 0.0e+00 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X2 [Tribolium castaneum] 755894366 XM_011297040.1 39 3.9646e-08 PREDICTED: Musca domestica multiple C2 and transmembrane domain-containing protein 1 (LOC101898395), transcript variant X1, mRNA -- -- -- -- Q6DN14 1246 3.7e-135 Multiple C2 and transmembrane domain-containing protein 1 OS=Homo sapiens GN=MCTP1 PE=2 SV=2 PF00322//PF00168//PF01355//PF00606//PF02542 Endothelin family//C2 domain//High potential iron-sulfur protein//Herpesvirus Glycoprotein B//YgbB family GO:0019646//GO:0019229//GO:0016114//GO:0006118 aerobic electron transport chain//regulation of vasoconstriction//terpenoid biosynthetic process//obsolete electron transport GO:0005515//GO:0008685//GO:0009055 protein binding//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity//electron carrier activity GO:0016020//GO:0005576 membrane//extracellular region KOG1030 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.23594 BP_3 289.20 4.35 3497 642919964 XP_008192146.1 1484 1.9e-161 PREDICTED: DNA repair protein XRCC1 isoform X1 [Tribolium castaneum]>gi|270005349|gb|EFA01797.1| hypothetical protein TcasGA2_TC007398 [Tribolium castaneum] -- -- -- -- -- K10803 XRCC1 DNA-repair protein XRCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K10803 Q8NCM8 667 4.2e-68 Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens GN=DYNC2H1 PE=1 SV=4 PF03028//PF01834 Dynein heavy chain and region D6 of dynein motor//XRCC1 N terminal domain GO:0007017//GO:0000012//GO:0007018//GO:0006281 microtubule-based process//single strand break repair//microtubule-based movement//DNA repair GO:0003684//GO:0003777 damaged DNA binding//microtubule motor activity GO:0030286//GO:0005634//GO:0005874 dynein complex//nucleus//microtubule KOG3595 Dyneins, heavy chain Cluster-8309.23595 BP_3 82.00 4.00 1279 332372662 AEE61473.1 1010 6.4e-107 unknown [Dendroctonus ponderosae]>gi|478255518|gb|ENN75735.1| hypothetical protein YQE_07695, partial [Dendroctonus ponderosae]>gi|546675924|gb|ERL87024.1| hypothetical protein D910_04426 [Dendroctonus ponderosae] 815909538 XM_012384963.1 186 2.28666e-90 PREDICTED: Bombus impatiens cilia- and flagella-associated protein 20 (LOC105680695), mRNA -- -- -- -- Q6B857 946 6.9e-101 Cilia- and flagella-associated protein 20 OS=Bos taurus GN=CFAP20 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3213 Transcription factor IIB Cluster-8309.23596 BP_3 241.61 3.94 3245 642919745 XP_008192047.1 1663 3.1e-182 PREDICTED: transmembrane protein 131 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92545 416 5.0e-39 Transmembrane protein 131 OS=Homo sapiens GN=TMEM131 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3620 Uncharacterized conserved protein Cluster-8309.23597 BP_3 2115.00 57.95 2051 642914087 XP_970230.2 1153 2.7e-123 PREDICTED: progestin and adipoQ receptor family member 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TCH7 592 1.2e-59 Progestin and adipoQ receptor family member 3 OS=Homo sapiens GN=PAQR3 PE=1 SV=2 PF01427//PF03006 D-ala-D-ala dipeptidase//Haemolysin-III related GO:0006508 proteolysis GO:0008237//GO:0016805 metallopeptidase activity//dipeptidase activity GO:0005618//GO:0016021 cell wall//integral component of membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.23598 BP_3 303.78 2.59 5935 642924788 XP_008194040.1 2706 6.4e-303 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 Q25637 1512 7.5e-166 Period circadian protein OS=Periplaneta americana GN=per PE=2 SV=2 PF08926//PF08447//PF00516//PF01554//PF00989 Domain of unknown function (DUF1908)//PAS fold//Envelope glycoprotein GP120//MatE//PAS fold GO:0015893//GO:0006855//GO:0016310//GO:0006355//GO:0055085//GO:0009069//GO:0006468//GO:0006810 drug transport//drug transmembrane transport//phosphorylation//regulation of transcription, DNA-templated//transmembrane transport//serine family amino acid metabolic process//protein phosphorylation//transport GO:0000287//GO:0015297//GO:0005515//GO:0004674//GO:0005524//GO:0015238 magnesium ion binding//antiporter activity//protein binding//protein serine/threonine kinase activity//ATP binding//drug transmembrane transporter activity GO:0016020//GO:0019031 membrane//viral envelope KOG3753 Circadian clock protein period Cluster-8309.23600 BP_3 42.92 0.35 6148 642924788 XP_008194040.1 1633 1.8e-178 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 P07663 976 1.1e-103 Period circadian protein OS=Drosophila melanogaster GN=per PE=1 SV=2 PF00989//PF01554//PF08447//PF00516//PF08926 PAS fold//MatE//PAS fold//Envelope glycoprotein GP120//Domain of unknown function (DUF1908) GO:0006810//GO:0006468//GO:0009069//GO:0055085//GO:0006355//GO:0016310//GO:0006855//GO:0015893 transport//protein phosphorylation//serine family amino acid metabolic process//transmembrane transport//regulation of transcription, DNA-templated//phosphorylation//drug transmembrane transport//drug transport GO:0015238//GO:0005524//GO:0004674//GO:0005515//GO:0015297//GO:0000287 drug transmembrane transporter activity//ATP binding//protein serine/threonine kinase activity//protein binding//antiporter activity//magnesium ion binding GO:0019031//GO:0016020 viral envelope//membrane KOG3753 Circadian clock protein period Cluster-8309.23601 BP_3 35.55 0.53 3544 270002821 EEZ99268.1 368 4.9e-32 spaetzle-like protein [Tribolium castaneum] 746845580 XM_011054780.1 39 3.35856e-08 PREDICTED: Acromyrmex echinatior protein spaetzle (LOC105145317), mRNA -- -- -- -- -- -- -- -- PF06379 L-rhamnose-proton symport protein (RhaT) GO:0015762//GO:0008645 rhamnose transport//hexose transport GO:0015153 rhamnose transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.23604 BP_3 12.78 0.57 1380 91083111 XP_970182.1 1198 1.1e-128 PREDICTED: L-galactose dehydrogenase [Tribolium castaneum]>gi|270007677|gb|EFA04125.1| hypothetical protein TcasGA2_TC014368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O81884 513 1.2e-50 L-galactose dehydrogenase OS=Arabidopsis thaliana GN=LGALDH PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1576 Predicted oxidoreductase Cluster-8309.23609 BP_3 1046.68 14.18 3849 189238033 XP_966902.2 1468 1.5e-159 PREDICTED: transmembrane protein 185A [Tribolium castaneum]>gi|270008773|gb|EFA05221.1| hypothetical protein TcasGA2_TC015362 [Tribolium castaneum] 642925153 XM_961809.3 242 5.19138e-121 PREDICTED: Tribolium castaneum transmembrane protein 185A (LOC655280), mRNA -- -- -- -- Q8R3R5 844 1.4e-88 Transmembrane protein 185B OS=Mus musculus GN=Tmem185b PE=2 SV=1 PF15048//PF02535//PF01757//PF00892 Organic solute transporter subunit beta protein//ZIP Zinc transporter//Acyltransferase family//EamA-like transporter family GO:0006810//GO:0015721//GO:0055085//GO:0030001 transport//bile acid and bile salt transport//transmembrane transport//metal ion transport GO:0046982//GO:0005215//GO:0016747//GO:0046873 protein heterodimerization activity//transporter activity//transferase activity, transferring acyl groups other than amino-acyl groups//metal ion transmembrane transporter activity GO:0005886//GO:0016021//GO:0016020 plasma membrane//integral component of membrane//membrane KOG3907 ZIP-like zinc transporter proteins Cluster-8309.23611 BP_3 8.71 0.40 1340 546673296 ERL84928.1 1697 1.4e-186 hypothetical protein D910_02351 [Dendroctonus ponderosae] 805819936 XM_003707231.2 102 1.18942e-43 PREDICTED: Megachile rotundata peptidyl-prolyl cis-trans isomerase-like 2 (LOC100880954), mRNA K10598 PPIL2, CYC4, CHP60 peptidyl-prolyl cis-trans isomerase-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10598 Q9D787 1188 6.3e-129 Peptidyl-prolyl cis-trans isomerase-like 2 OS=Mus musculus GN=Ppil2 PE=1 SV=2 PF00160//PF11789 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Zinc-finger of the MIZ type in Nse subunit GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755//GO:0008270 peptidyl-prolyl cis-trans isomerase activity//zinc ion binding -- -- KOG0883 Cyclophilin type, U box-containing peptidyl-prolyl cis-trans isomerase Cluster-8309.23613 BP_3 55.97 2.98 1198 332374344 AEE62313.1 1119 1.4e-119 unknown [Dendroctonus ponderosae]>gi|478253634|gb|ENN73938.1| hypothetical protein YQE_09440, partial [Dendroctonus ponderosae]>gi|546684541|gb|ERL94169.1| hypothetical protein D910_11451 [Dendroctonus ponderosae] -- -- -- -- -- K01069 E3.1.2.6, gloB hydroxyacylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01069 Q3B7M2 897 3.1e-95 Hydroxyacylglutathione hydrolase, mitochondrial OS=Bos taurus GN=HAGH PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0813 Glyoxylase Cluster-8309.23614 BP_3 5251.51 44.92 5927 642925566 XP_008194602.1 2489 9.3e-278 PREDICTED: chorion peroxidase-like isoform X1 [Tribolium castaneum]>gi|270009250|gb|EFA05698.1| hypothetical protein TcasGA2_TC015234 [Tribolium castaneum] 817214764 XM_012428160.1 98 8.98181e-41 PREDICTED: Orussus abietinus uncharacterized LOC105701425 (LOC105701425), mRNA -- -- -- -- Q9VEG6 1020 8.4e-109 Chorion peroxidase OS=Drosophila melanogaster GN=Pxt PE=2 SV=3 -- -- GO:0006804//GO:0055114//GO:0006979 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress GO:0020037//GO:0004601 heme binding//peroxidase activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.23615 BP_3 39.00 0.75 2810 642940459 XP_008196455.1 1006 4.1e-106 PREDICTED: uncharacterized protein LOC661701 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10608 TRIM37, MUL tripartite motif-containing protein 37 http://www.genome.jp/dbget-bin/www_bget?ko:K10608 O94972 734 5.8e-76 E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens GN=TRIM37 PE=1 SV=2 PF00917//PF01165//PF02533 MATH domain//Ribosomal protein S21//Photosystem II 4 kDa reaction centre component GO:0042254//GO:0015979//GO:0006412 ribosome biogenesis//photosynthesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840//GO:0009523//GO:0009539 ribosome//photosystem II//photosystem II reaction center KOG2707 Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold) Cluster-8309.23617 BP_3 121.53 1.31 4766 91092828 XP_968011.1 2277 2.9e-253 PREDICTED: structural maintenance of chromosomes protein 4 [Tribolium castaneum]>gi|270004790|gb|EFA01238.1| gluon [Tribolium castaneum] -- -- -- -- -- K06675 SMC4 structural maintenance of chromosome 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06675 P50532 1654 2.1e-182 Structural maintenance of chromosomes protein 4 OS=Xenopus laevis GN=smc4 PE=1 SV=1 PF06160//PF06470//PF16519//PF16331//PF06009//PF13304//PF04632//PF01017 Septation ring formation regulator, EzrA//SMC proteins Flexible Hinge Domain//Tetramerisation domain of TRPM//TolA binding protein trimerisation//Laminin Domain II//AAA domain, putative AbiEii toxin, Type IV TA system//Fusaric acid resistance protein family//STAT protein, all-alpha domain GO:0007155//GO:0006259//GO:0051276//GO:0000921//GO:0006355//GO:0007165//GO:0051262//GO:0006810//GO:0070206 cell adhesion//DNA metabolic process//chromosome organization//septin ring assembly//regulation of transcription, DNA-templated//signal transduction//protein tetramerization//transport//protein trimerization GO:0004871//GO:0005515//GO:0003700//GO:0005524 signal transducer activity//protein binding//transcription factor activity, sequence-specific DNA binding//ATP binding GO:0005694//GO:0043229//GO:0005886//GO:0005667//GO:0016021//GO:0005940 chromosome//intracellular organelle//plasma membrane//transcription factor complex//integral component of membrane//septin ring KOG0996 Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) Cluster-8309.23618 BP_3 288.34 3.07 4826 91092828 XP_968011.1 2813 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 4 [Tribolium castaneum]>gi|270004790|gb|EFA01238.1| gluon [Tribolium castaneum] -- -- -- -- -- K06675 SMC4 structural maintenance of chromosome 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06675 P50532 1880 1.3e-208 Structural maintenance of chromosomes protein 4 OS=Xenopus laevis GN=smc4 PE=1 SV=1 PF06470//PF00005//PF13304//PF06160 SMC proteins Flexible Hinge Domain//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//Septation ring formation regulator, EzrA GO:0000921//GO:0051276//GO:0006259 septin ring assembly//chromosome organization//DNA metabolic process GO:0005515//GO:0005524//GO:0016887 protein binding//ATP binding//ATPase activity GO:0005940//GO:0016021//GO:0005694 septin ring//integral component of membrane//chromosome KOG0996 Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) Cluster-8309.23619 BP_3 166.98 27.91 580 478255411 ENN75633.1 568 5.2e-56 hypothetical protein YQE_07811, partial [Dendroctonus ponderosae] -- -- -- -- -- K02899 RP-L27, MRPL27, rpmA large subunit ribosomal protein L27 http://www.genome.jp/dbget-bin/www_bget?ko:K02899 Q99N92 235 8.7e-19 39S ribosomal protein L27, mitochondrial OS=Mus musculus GN=Mrpl27 PE=2 SV=1 PF01016 Ribosomal L27 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG4600 Mitochondrial ribosomal protein MRP7 (L2) Cluster-8309.2362 BP_3 140.26 1.64 4410 270010992 EFA07440.1 616 1.1e-60 hormone receptor in 46-like protein [Tribolium castaneum] 443682251 KC020245.1 163 4.90628e-77 Monochamus alternatus nuclear hormone receptor HR3-like protein (HR3) mRNA, partial cds K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 Q08882 463 2.4e-44 Probable nuclear hormone receptor HR3 OS=Manduca sexta GN=HR3 PE=2 SV=1 PF07998//PF00105 Peptidase family M54//Zinc finger, C4 type (two domains) GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4216 Steroid hormone nuclear receptor Cluster-8309.23621 BP_3 6.00 0.34 1147 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23623 BP_3 49.07 5.14 752 91080023 XP_972063.1 415 3.7e-38 PREDICTED: beta-1,3-glucan-binding protein isoform X1 [Tribolium castaneum]>gi|270004908|gb|EFA01356.1| Gram-negative bacteria binding protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NHA8 404 2.9e-38 Gram-negative bacteria-binding protein 3 OS=Drosophila melanogaster GN=GNBP3 PE=1 SV=2 PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.23626 BP_3 326.17 2.64 6237 642932464 XP_008197125.1 6560 0.0e+00 PREDICTED: WD repeat-containing protein 81 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17601 WDR81 WD repeat-containing protein 81 http://www.genome.jp/dbget-bin/www_bget?ko:K17601 D4A929 968 9.5e-103 WD repeat-containing protein 81 OS=Rattus norvegicus GN=Wdr81 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.23627 BP_3 25.00 0.61 2279 7320913 CAA72032.2 1280 5.6e-138 masquerade-like protein [Pacifastacus leniusculus] 301030826 GU373915.1 560 0 Portunus trituberculatus masquerade-like protein mRNA, partial cds -- -- -- -- P26262 406 5.1e-38 Plasma kallikrein OS=Mus musculus GN=Klkb1 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23629 BP_3 32.81 0.66 2685 546681143 ERL91293.1 277 1.3e-21 hypothetical protein D910_08626 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08603 Adenylate cyclase associated (CAP) C terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.2363 BP_3 45.04 1.03 2400 357616848 EHJ70441.1 1439 2.1e-156 serine protease [Danaus plexippus] 642930385 XM_001813893.2 99 1.00287e-41 PREDICTED: Tribolium castaneum serine proteinase stubble (LOC662802), mRNA -- -- -- -- Q05319 650 2.7e-66 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089//PF00548 Trypsin//3C cysteine protease (picornain 3C) GO:0006508 proteolysis GO:0004252//GO:0004197 serine-type endopeptidase activity//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.23630 BP_3 9.00 6.75 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.23631 BP_3 18.00 1.10 1079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23632 BP_3 76.00 17.57 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23633 BP_3 3.00 0.43 631 642917050 XP_008191099.1 249 5.5e-19 PREDICTED: ras-related GTP-binding protein C isoform X1 [Tribolium castaneum] -- -- -- -- -- K16186 RRAGC_D Ras-related GTP-binding protein C/D http://www.genome.jp/dbget-bin/www_bget?ko:K16186 Q9HB90 167 7.2e-11 Ras-related GTP-binding protein C OS=Homo sapiens GN=RRAGC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3887 Predicted small GTPase involved in nuclear protein import Cluster-8309.23635 BP_3 789.00 10.18 4028 642932100 XP_008196854.1 1731 5.0e-190 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 642932099 XM_008198632.1 463 0 PREDICTED: Tribolium castaneum SPRY domain-containing SOCS box protein 1 (LOC664070), transcript variant X2, mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 5.1e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF00622//PF07525//PF01213 SPRY domain//SOCS box//Adenylate cyclase associated (CAP) N terminal GO:0035556//GO:0007010 intracellular signal transduction//cytoskeleton organization GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.23639 BP_3 75.93 1.19 3372 642922112 XP_008193020.1 613 1.8e-60 PREDICTED: calcium channel flower isoform X2 [Tribolium castaneum]>gi|270007428|gb|EFA03876.1| hypothetical protein TcasGA2_TC014000 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MXW6 324 2.4e-28 Calcium channel flower OS=Drosophila willistoni GN=flower PE=3 SV=2 PF03613//PF10233 PTS system mannose/fructose/sorbose family IID component//Uncharacterized conserved protein CG6151-P GO:0009401//GO:0006816//GO:0070588//GO:0048488 phosphoenolpyruvate-dependent sugar phosphotransferase system//calcium ion transport//calcium ion transmembrane transport//synaptic vesicle endocytosis GO:0005262 calcium channel activity GO:0016021//GO:0030285 integral component of membrane//integral component of synaptic vesicle membrane KOG4085 Uncharacterized conserved protein Cluster-8309.23640 BP_3 55.28 0.80 3608 189240899 XP_972980.2 1075 5.2e-114 PREDICTED: protein numb isoform X1 [Tribolium castaneum] 642934703 XM_008199556.1 270 1.32377e-136 PREDICTED: Tribolium castaneum protein numb (LOC661741), transcript variant X2, mRNA K06057 NUMBL numb http://www.genome.jp/dbget-bin/www_bget?ko:K06057 P16554 816 2.3e-85 Protein numb OS=Drosophila melanogaster GN=numb PE=1 SV=2 PF00640//PF07353//PF05587//PF08168 Phosphotyrosine interaction domain (PTB/PID)//Uroplakin II//Anthrax receptor extracellular domain//NUC205 domain GO:0007165//GO:0061024 signal transduction//membrane organization GO:0004872//GO:0005515 receptor activity//protein binding GO:0030176//GO:0005634//GO:0016021 integral component of endoplasmic reticulum membrane//nucleus//integral component of membrane KOG3537 Adaptor protein NUMB Cluster-8309.23642 BP_3 13.21 0.46 1670 478250399 ENN70894.1 961 4.0e-101 hypothetical protein YQE_12299, partial [Dendroctonus ponderosae]>gi|546672890|gb|ERL84613.1| hypothetical protein D910_02041 [Dendroctonus ponderosae] -- -- -- -- -- K13421 UMPS uridine monophosphate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K13421 Q01637 709 2.7e-73 Uridine 5'-monophosphate synthase OS=Drosophila melanogaster GN=r-l PE=2 SV=2 PF08272//PF00215//PF00156 Topoisomerase I zinc-ribbon-like//Orotidine 5'-phosphate decarboxylase / HUMPS family//Phosphoribosyl transferase domain GO:0009116//GO:0006206//GO:0006265//GO:0006207 nucleoside metabolic process//pyrimidine nucleobase metabolic process//DNA topological change//'de novo' pyrimidine nucleobase biosynthetic process GO:0004590//GO:0003918//GO:0003677 orotidine-5'-phosphate decarboxylase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding GO:0005694 chromosome KOG1377 Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase Cluster-8309.23643 BP_3 1.00 0.37 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23644 BP_3 705.78 10.55 3516 642920404 XP_008192334.1 315 6.8e-26 PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum]>gi|642920406|ref|XP_967709.2| PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23647 BP_3 7.00 1.46 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23651 BP_3 428.00 3.78 5744 91080461 XP_969971.1 2463 9.4e-275 PREDICTED: menin [Tribolium castaneum]>gi|270005763|gb|EFA02211.1| hypothetical protein TcasGA2_TC007870 [Tribolium castaneum] 642919233 XM_964878.2 122 3.96399e-54 PREDICTED: Tribolium castaneum menin (LOC658495), mRNA K14970 MEN1, MNN1 menin http://www.genome.jp/dbget-bin/www_bget?ko:K14970 O88559 1191 1.2e-128 Menin OS=Mus musculus GN=Men1 PE=1 SV=2 PF05053 Menin -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.23652 BP_3 493.63 6.49 3956 478255072 ENN75302.1 3267 0.0e+00 hypothetical protein YQE_08079, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1260 8.3e-137 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.23653 BP_3 4.00 0.73 556 642910859 XP_008193438.1 517 4.1e-50 PREDICTED: mitogen-activated protein kinase 14B-like [Tribolium castaneum] 733868735 XM_003201950.2 94 1.33262e-39 PREDICTED: Meleagris gallopavo mitogen-activated protein kinase 11 (MAPK11), mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 485 8.6e-48 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0660 Mitogen-activated protein kinase Cluster-8309.23655 BP_3 23.36 0.92 1520 817076849 XP_012260720.1 342 2.2e-29 PREDICTED: beclin 1-associated autophagy-related key regulator isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10186//PF00643 Vacuolar sorting 38 and autophagy-related subunit 14//B-box zinc finger GO:0010508 positive regulation of autophagy GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.23657 BP_3 67.59 1.17 3085 91086917 XP_971585.1 888 2.1e-92 PREDICTED: DNA polymerase iota [Tribolium castaneum]>gi|270009670|gb|EFA06118.1| hypothetical protein TcasGA2_TC008961 [Tribolium castaneum] -- -- -- -- -- K03510 POLI DNA polymerase iota http://www.genome.jp/dbget-bin/www_bget?ko:K03510 Q6R3M4 585 1.2e-58 DNA polymerase iota OS=Mus musculus GN=Poli PE=1 SV=1 PF02245//PF11799//PF00817//PF06390 Methylpurine-DNA glycosylase (MPG)//impB/mucB/samB family C-terminal domain//impB/mucB/samB family//Neuroendocrine-specific golgi protein P55 (NESP55) GO:0006260//GO:0006281//GO:0071107//GO:0006284 DNA replication//DNA repair//response to parathyroid hormone//base-excision repair GO:0003684//GO:0003887//GO:0003905//GO:0003677 damaged DNA binding//DNA-directed DNA polymerase activity//alkylbase DNA N-glycosylase activity//DNA binding GO:0042575 DNA polymerase complex KOG2095 DNA polymerase iota/DNA damage inducible protein Cluster-8309.23658 BP_3 72.41 1.23 3140 91086917 XP_971585.1 1557 5.8e-170 PREDICTED: DNA polymerase iota [Tribolium castaneum]>gi|270009670|gb|EFA06118.1| hypothetical protein TcasGA2_TC008961 [Tribolium castaneum] -- -- -- -- -- K03510 POLI DNA polymerase iota http://www.genome.jp/dbget-bin/www_bget?ko:K03510 Q9UNA4 786 6.1e-82 DNA polymerase iota OS=Homo sapiens GN=POLI PE=1 SV=3 PF02245//PF06390//PF00817//PF11799 Methylpurine-DNA glycosylase (MPG)//Neuroendocrine-specific golgi protein P55 (NESP55)//impB/mucB/samB family//impB/mucB/samB family C-terminal domain GO:0006281//GO:0071107//GO:0006284 DNA repair//response to parathyroid hormone//base-excision repair GO:0003684//GO:0003905//GO:0003677 damaged DNA binding//alkylbase DNA N-glycosylase activity//DNA binding -- -- KOG2095 DNA polymerase iota/DNA damage inducible protein Cluster-8309.2366 BP_3 25.24 0.41 3274 642916215 XP_974065.2 1175 1.2e-125 PREDICTED: outer dense fiber protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYX5 387 1.2e-35 Outer dense fiber protein 2 OS=Rattus norvegicus GN=Odf2 PE=1 SV=2 PF00769//PF08702//PF00038//PF10473//PF04508//PF01544//PF02507//PF06156//PF05791//PF05531 Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Intermediate filament protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Viral A-type inclusion protein repeat//CorA-like Mg2+ transporter protein//Photosystem I reaction centre subunit III//Protein of unknown function (DUF972)//Bacillus haemolytic enterotoxin (HBL)//Nucleopolyhedrovirus P10 protein GO:0030168//GO:0016032//GO:0015979//GO:0030001//GO:0006260//GO:0051258//GO:0055085//GO:0007165//GO:0009405 platelet activation//viral process//photosynthesis//metal ion transport//DNA replication//protein polymerization//transmembrane transport//signal transduction//pathogenesis GO:0046873//GO:0030674//GO:0042803//GO:0008092//GO:0005102//GO:0008134//GO:0045502//GO:0005198 metal ion transmembrane transporter activity//protein binding, bridging//protein homodimerization activity//cytoskeletal protein binding//receptor binding//transcription factor binding//dynein binding//structural molecule activity GO:0016020//GO:0005667//GO:0030286//GO:0005737//GO:0005577//GO:0009538//GO:0005882//GO:0009522//GO:0019028//GO:0019898 membrane//transcription factor complex//dynein complex//cytoplasm//fibrinogen complex//photosystem I reaction center//intermediate filament//photosystem I//viral capsid//extrinsic component of membrane -- -- Cluster-8309.23660 BP_3 145.65 5.50 1567 332374492 AEE62387.1 845 1.1e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05109 333 1.0e-29 Venom allergen 5 (Fragment) OS=Polistes annularis PE=1 SV=1 PF07782 DC-STAMP-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.23662 BP_3 61.64 0.62 5103 642933422 XP_008197411.1 2992 0.0e+00 PREDICTED: uncharacterized protein LOC661343 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N957 524 2.4e-51 Ankyrin repeat and fibronectin type-III domain-containing protein 1 OS=Homo sapiens GN=ANKFN1 PE=2 SV=2 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG4485 Uncharacterized conserved protein, contains ankyrin and FN3 repeats Cluster-8309.23663 BP_3 565.36 7.12 4119 642933430 XP_008197415.1 3324 0.0e+00 PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N957 630 9.8e-64 Ankyrin repeat and fibronectin type-III domain-containing protein 1 OS=Homo sapiens GN=ANKFN1 PE=2 SV=2 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG4485 Uncharacterized conserved protein, contains ankyrin and FN3 repeats Cluster-8309.23665 BP_3 32.14 1.07 1737 642933424 XP_008197412.1 1093 2.1e-116 PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N957 360 8.4e-33 Ankyrin repeat and fibronectin type-III domain-containing protein 1 OS=Homo sapiens GN=ANKFN1 PE=2 SV=2 PF12678//PF13606 RING-H2 zinc finger//Ankyrin repeat -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.23666 BP_3 195.81 5.89 1893 642933420 XP_008197410.1 1668 4.7e-183 PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N957 355 3.5e-32 Ankyrin repeat and fibronectin type-III domain-containing protein 1 OS=Homo sapiens GN=ANKFN1 PE=2 SV=2 PF13606//PF12678 Ankyrin repeat//RING-H2 zinc finger -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.23667 BP_3 227.40 6.42 1998 642927673 XP_008195359.1 2978 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase 1 [Tribolium castaneum] 795069100 XM_012019555.1 194 1.28862e-94 PREDICTED: Vollenhovia emeryi diacylglycerol kinase 1 (LOC105565940), transcript variant X3, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q9Y6T7 1942 3.5e-216 Diacylglycerol kinase beta OS=Homo sapiens GN=DGKB PE=2 SV=2 PF00628//PF07649//PF07163//PF00130//PF00609//PF00036//PF13202//PF00781 PHD-finger//C1-like domain//Pex26 protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//EF hand//EF hand//Diacylglycerol kinase catalytic domain GO:0035556//GO:0055114//GO:0046486//GO:0007205//GO:0009395//GO:0045046 intracellular signal transduction//oxidation-reduction process//glycerolipid metabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//protein import into peroxisome membrane GO:0005509//GO:0016301//GO:0047134//GO:0004143//GO:0032403//GO:0005515 calcium ion binding//kinase activity//protein-disulfide reductase activity//diacylglycerol kinase activity//protein complex binding//protein binding GO:0005779 integral component of peroxisomal membrane KOG1169 Diacylglycerol kinase Cluster-8309.2367 BP_3 27.00 0.33 4287 91091450 XP_972739.1 3515 0.0e+00 PREDICTED: cadherin-86C [Tribolium castaneum]>gi|270001274|gb|EEZ97721.1| hypothetical protein TcasGA2_TC011230 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGW1 1635 3.0e-180 Cadherin-86C OS=Drosophila melanogaster GN=Cad86C PE=2 SV=3 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.23672 BP_3 183.00 4.30 2343 546679056 ERL89579.1 1185 5.9e-127 hypothetical protein D910_06944 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N6Q8 485 3.6e-47 Methyltransferase-like protein 25 OS=Homo sapiens GN=METTL25 PE=2 SV=2 PF05206 Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity -- -- KOG2651 rRNA adenine N-6-methyltransferase Cluster-8309.23674 BP_3 134.00 19.32 626 91091946 XP_967800.1 569 4.3e-56 PREDICTED: 39S ribosomal protein L30, mitochondrial [Tribolium castaneum]>gi|270001145|gb|EEZ97592.1| hypothetical protein TcasGA2_TC011456 [Tribolium castaneum] -- -- -- -- -- K02907 RP-L30, MRPL30, rpmD large subunit ribosomal protein L30 http://www.genome.jp/dbget-bin/www_bget?ko:K02907 Q4R6U7 185 5.9e-13 39S ribosomal protein L30, mitochondrial OS=Macaca fascicularis GN=MRPL30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4799 Mitochondrial ribosomal protein L30 Cluster-8309.23675 BP_3 1.00 0.92 337 157106389 XP_001649301.1 203 6.3e-14 AAEL014668-PA, partial [Aedes aegypti]>gi|108868849|gb|EAT33074.1| AAEL014668-PA, partial [Aedes aegypti] -- -- -- -- -- K08803 DAPK death-associated protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08803 Q8BZ25 182 7.1e-13 Ankyrin repeat and protein kinase domain-containing protein 1 OS=Mus musculus GN=Ankk1 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.23676 BP_3 447.30 16.29 1615 642939406 XP_008193285.1 1115 5.4e-119 PREDICTED: uncharacterized protein LOC661130 [Tribolium castaneum] 642939405 XM_008195063.1 204 2.86347e-100 PREDICTED: Tribolium castaneum uncharacterized LOC661130 (LOC661130), mRNA -- -- -- -- Q61830 178 9.9e-12 Macrophage mannose receptor 1 OS=Mus musculus GN=Mrc1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23677 BP_3 414.53 2.14 9623 270005280 EFA01728.1 8299 0.0e+00 hypothetical protein TcasGA2_TC007308 [Tribolium castaneum] 642920256 XM_008194048.1 93 8.79348e-38 PREDICTED: Tribolium castaneum pecanex-like protein 1 (LOC664487), transcript variant X2, mRNA -- -- -- -- Q96RV3 3295 0.0e+00 Pecanex-like protein 1 OS=Homo sapiens GN=PCNX PE=1 SV=2 PF05041//PF11095//PF06753 Pecanex protein (C-terminus)//Gem-associated protein 7 (Gemin7)//Bradykinin GO:0007165//GO:0006950 signal transduction//response to stress GO:0005179 hormone activity GO:0032797//GO:0016021//GO:0005576 SMN complex//integral component of membrane//extracellular region KOG3604 Pecanex Cluster-8309.23678 BP_3 325.00 4.82 3545 642930595 XP_001807608.2 1655 2.8e-181 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05805//PF14850//PF05777//PF00240//PF14560 L6 membrane protein//DNA-binding domain of Proline dehydrogenase//Drosophila accessory gland-specific peptide 26Ab (Acp26Ab)//Ubiquitin family//Ubiquitin-like domain GO:0055114//GO:0007617//GO:0006525//GO:0006561 oxidation-reduction process//mating behavior//arginine metabolic process//proline biosynthetic process GO:0003842//GO:0005515 1-pyrroline-5-carboxylate dehydrogenase activity//protein binding GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.23679 BP_3 1233.22 32.16 2140 571533289 XP_006561360.1 595 1.4e-58 PREDICTED: uncharacterized protein LOC725964 isoform X1 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88281 393 1.5e-36 Multiple epidermal growth factor-like domains protein 6 OS=Rattus norvegicus GN=Megf6 PE=1 SV=1 PF07645 Calcium-binding EGF domain -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.23680 BP_3 33.15 0.48 3643 571533295 XP_006561362.1 595 2.4e-58 PREDICTED: uncharacterized protein LOC725964 isoform X3 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88281 393 2.6e-36 Multiple epidermal growth factor-like domains protein 6 OS=Rattus norvegicus GN=Megf6 PE=1 SV=1 PF07645//PF15433//PF02793//PF03079 Calcium-binding EGF domain//Mitochondrial 28S ribosomal protein S31//Hormone receptor domain//ARD/ARD' family GO:0007186//GO:0055114//GO:0042254 G-protein coupled receptor signaling pathway//oxidation-reduction process//ribosome biogenesis GO:0010309//GO:0004930//GO:0003735//GO:0005509 acireductone dioxygenase [iron(II)-requiring] activity//G-protein coupled receptor activity//structural constituent of ribosome//calcium ion binding GO:0005763//GO:0016020//GO:0005840 mitochondrial small ribosomal subunit//membrane//ribosome -- -- Cluster-8309.23681 BP_3 422.00 17.26 1470 642935669 XP_008198107.1 344 1.2e-29 PREDICTED: uncharacterized protein LOC103314279 [Tribolium castaneum]>gi|270013301|gb|EFA09749.1| hypothetical protein TcasGA2_TC011888 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23682 BP_3 5.00 3.14 365 270005445 EFA01893.1 206 3.1e-14 hypothetical protein TcasGA2_TC007503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23683 BP_3 108.00 1.98 2918 91087879 XP_969925.1 546 9.2e-53 PREDICTED: paired mesoderm homeobox protein 2 [Tribolium castaneum]>gi|270012765|gb|EFA09213.1| munster [Tribolium castaneum] 154146242 NM_001100174.1 103 7.30103e-44 Rattus norvegicus aristaless related homeobox (Arx), mRNA >gnl|BL_ORD_ID|4283590 Rattus norvegicus aristaless-related homeobox protein mRNA, complete cds K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 A6YP92 326 1.2e-28 Homeobox protein ARX OS=Rattus norvegicus GN=Arx PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.23686 BP_3 430.11 7.29 3134 91077384 XP_975249.1 1307 5.7e-141 PREDICTED: protoporphyrinogen oxidase [Tribolium castaneum]>gi|270001648|gb|EEZ98095.1| hypothetical protein TcasGA2_TC000508 [Tribolium castaneum] -- -- -- -- -- K00231 PPOX, hemY oxygen-dependent protoporphyrinogen oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00231 P51175 757 1.4e-78 Protoporphyrinogen oxidase OS=Mus musculus GN=Ppox PE=1 SV=1 PF01266//PF02269//PF07992//PF01593//PF12831//PF00070 FAD dependent oxidoreductase//Transcription initiation factor IID, 18kD subunit//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0006366//GO:0055114//GO:0008152 transcription from RNA polymerase II promoter//oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG3901 Transcription initiation factor IID subunit Cluster-8309.23687 BP_3 803.33 6.51 6235 642940402 XP_008200549.1 6889 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 752868301 XM_011252918.1 50 4.55564e-14 PREDICTED: Camponotus floridanus Down syndrome cell adhesion molecule-like protein Dscam2 (LOC105248250), mRNA -- -- -- -- Q9VS29 2959 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF03824//PF05790//PF13895//PF00041 High-affinity nickel-transport protein//Immunoglobulin C2-set domain//Immunoglobulin domain//Fibronectin type III domain GO:0007155//GO:0035444//GO:0015675 cell adhesion//nickel cation transmembrane transport//nickel cation transport GO:0015099//GO:0005515//GO:0046872 nickel cation transmembrane transporter activity//protein binding//metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.23688 BP_3 13.00 0.74 1137 662212467 XP_008479970.1 181 7.6e-11 PREDICTED: zinc finger protein 425-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 140 1.8e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF16622//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.23689 BP_3 55.28 1.19 2529 642931425 XP_008196577.1 1339 8.9e-145 PREDICTED: tRNA (uracil-5-)-methyltransferase homolog A [Tribolium castaneum] -- -- -- -- -- K15332 TRMT2A tRNA (uracil-5-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15332 Q8IZ69 847 4.1e-89 tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 PF05958//PF09445//PF02384//PF05175//PF01135//PF02390//PF08241//PF00076//PF01209//PF05401//PF03602 tRNA (Uracil-5-)-methyltransferase//RNA cap guanine-N2 methyltransferase//N-6 DNA Methylase//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Putative methyltransferase//Methyltransferase domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//ubiE/COQ5 methyltransferase family//Nodulation protein S (NodS)//Conserved hypothetical protein 95 GO:0008033//GO:0006396//GO:0009312//GO:0006464//GO:0031167//GO:0009451//GO:0006479//GO:0009877//GO:0046500//GO:0006306//GO:0006400//GO:0001510//GO:0008152//GO:0009452 tRNA processing//RNA processing//oligosaccharide biosynthetic process//cellular protein modification process//rRNA methylation//RNA modification//protein methylation//nodulation//S-adenosylmethionine metabolic process//DNA methylation//tRNA modification//RNA methylation//metabolic process//7-methylguanosine RNA capping GO:0008170//GO:0008168//GO:0008176//GO:0004719//GO:0003676//GO:0003677//GO:0008757//GO:0008173 N-methyltransferase activity//methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//nucleic acid binding//DNA binding//S-adenosylmethionine-dependent methyltransferase activity//RNA methyltransferase activity -- -- KOG2187 tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes Cluster-8309.2369 BP_3 640.72 127.94 533 270006762 EFA03210.1 351 6.9e-31 hypothetical protein TcasGA2_TC013130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 260 1.0e-21 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.23692 BP_3 145.62 2.02 3771 847111375 XP_012814894.1 858 7.9e-89 PREDICTED: uncharacterized protein LOC105946753 [Xenopus (Silurana) tropicalis]>gi|847149816|ref|XP_012822809.1| PREDICTED: uncharacterized protein LOC105947875 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.23694 BP_3 3.48 0.32 814 546686052 ERL95452.1 317 9.2e-27 hypothetical protein D910_12714 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q01842 131 1.4e-06 Ets DNA-binding protein pokkuri OS=Drosophila melanogaster GN=aop PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.23696 BP_3 752.73 5.79 6560 642918326 XP_008199092.1 2616 1.9e-292 PREDICTED: protein Shroom [Tribolium castaneum] -- -- -- -- -- K18625 SHROOM protein Shroom http://www.genome.jp/dbget-bin/www_bget?ko:K18625 Q09JY9 372 1.3e-33 Protein Shroom2 OS=Xenopus tropicalis GN=shroom2 PE=2 SV=1 PF07353 Uroplakin II GO:0061024 membrane organization -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.23697 BP_3 692.57 6.61 5344 91093220 XP_967110.1 1998 7.2e-221 PREDICTED: putative Golgi pH regulator C [Tribolium castaneum]>gi|270016591|gb|EFA13037.1| hypothetical protein TcasGA2_TC010568 [Tribolium castaneum] 170065886 XM_001868022.1 246 4.31876e-123 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA -- -- -- -- B5X1G3 1455 2.7e-159 Golgi pH regulator OS=Salmo salar GN=gpr89 PE=2 SV=1 PF06293//PF00069//PF12537//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//The Golgi pH Regulator (GPHR) Family N-terminal//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG2417 Predicted G-protein coupled receptor Cluster-8309.23698 BP_3 2130.00 52.56 2245 189240491 XP_001810703.1 929 2.8e-97 PREDICTED: uncharacterized protein LOC100142309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.23699 BP_3 16.00 0.36 2453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23700 BP_3 148.02 1.86 4122 270001539 EEZ97986.1 1833 7.6e-202 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 8.92211e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1089 5.8e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.23701 BP_3 227.60 2.75 4285 270001539 EEZ97986.1 2008 4.0e-222 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 9.27803e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1089 6.1e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.23703 BP_3 1.00 4.87 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23704 BP_3 937.08 7.60 6235 189240093 XP_972388.2 1454 1.0e-157 PREDICTED: myosin heavy chain, clone 203 isoform X1 [Tribolium castaneum]>gi|270012237|gb|EFA08685.1| hypothetical protein TcasGA2_TC006355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04048//PF05929//PF01465//PF04508//PF10186 Sec8 exocyst complex component specific domain//Phage capsid scaffolding protein (GPO) serine peptidase//GRIP domain//Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508//GO:0019069//GO:0015031//GO:0000042//GO:0016032//GO:0006904 positive regulation of autophagy//viral capsid assembly//protein transport//protein targeting to Golgi//viral process//vesicle docking involved in exocytosis GO:0005515 protein binding GO:0000145 exocyst -- -- Cluster-8309.23709 BP_3 2.00 0.95 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23712 BP_3 38.00 2.74 959 645008379 XP_003425747.2 159 2.3e-08 PREDICTED: uncharacterized protein LOC100680211 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01025 GrpE GO:0006457 protein folding GO:0000774//GO:0051087//GO:0042803 adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity -- -- -- -- Cluster-8309.23714 BP_3 94.00 7.49 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23715 BP_3 17.00 0.73 1407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05151//PF03088//PF05669 Photosystem II reaction centre M protein (PsbM)//Strictosidine synthase//SOH1 GO:0042432//GO:0016114//GO:0015979//GO:0009058//GO:0019684//GO:0006355 indole biosynthetic process//terpenoid biosynthetic process//photosynthesis//biosynthetic process//photosynthesis, light reaction//regulation of transcription, DNA-templated GO:0001104//GO:0016844 RNA polymerase II transcription cofactor activity//strictosidine synthase activity GO:0016021//GO:0016592//GO:0009523 integral component of membrane//mediator complex//photosystem II -- -- Cluster-8309.23716 BP_3 197.01 0.97 10096 -- -- -- -- -- 642912856 XM_008203060.1 43 5.7534e-10 PREDICTED: Tribolium castaneum AP-1 complex subunit sigma-2 (LOC659702), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23717 BP_3 546.54 2.66 10208 -- -- -- -- -- 642912856 XM_008203060.1 43 5.81746e-10 PREDICTED: Tribolium castaneum AP-1 complex subunit sigma-2 (LOC659702), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23718 BP_3 42.38 1.78 1442 332373248 AEE61765.1 735 5.5e-75 unknown [Dendroctonus ponderosae]>gi|478262478|gb|ENN81149.1| hypothetical protein YQE_02515, partial [Dendroctonus ponderosae]>gi|546672789|gb|ERL84545.1| hypothetical protein D910_01975 [Dendroctonus ponderosae] 242011937 XM_002426655.1 180 5.5983e-87 Pediculus humanus corporis clathrin coat assembly protein ap19, putative, mRNA K12394 AP1S1_2 AP-1 complex subunit sigma 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12394 Q9DB50 659 1.5e-67 AP-1 complex subunit sigma-2 OS=Mus musculus GN=Ap1s2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0934 Clathrin adaptor complex, small subunit Cluster-8309.23719 BP_3 26.00 2.61 772 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.23721 BP_3 32.25 0.88 2058 270006394 EFA02842.1 849 4.8e-88 hypothetical protein TcasGA2_TC007619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00214 353 6.4e-32 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.23724 BP_3 25.00 0.78 1846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23725 BP_3 127.00 5.18 1474 296023724 ADG83846.1 1858 3.4e-205 serine proteinase-like protein [Scylla paramamosain] 296023723 GU250783.1 1262 0 Scylla paramamosain serine proteinase-like protein mRNA, complete cds -- -- -- -- Q05319 367 1.1e-33 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23727 BP_3 199.69 1.52 6633 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF14249//PF00028 Tocopherol cyclase//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0009976//GO:0005509 tocopherol cyclase activity//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.23728 BP_3 28.00 5.48 538 642931814 XP_008196744.1 589 1.8e-58 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 482 1.8e-47 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.23729 BP_3 72.04 0.43 8378 91077836 XP_971324.1 1583 1.5e-172 PREDICTED: DNA helicase MCM9 [Tribolium castaneum]>gi|270001478|gb|EEZ97925.1| hypothetical protein TcasGA2_TC000312 [Tribolium castaneum] -- -- -- -- -- K10738 MCM9 DNA helicase MCM9 http://www.genome.jp/dbget-bin/www_bget?ko:K10738 I0IUP4 1298 6.9e-141 DNA helicase MCM9 OS=Gallus gallus GN=MCM9 PE=1 SV=2 PF07726//PF00493//PF07728//PF10505//PF08516//PF00158//PF00004//PF08073 ATPase family associated with various cellular activities (AAA)//MCM2/3/5 family//AAA domain (dynein-related subfamily)//NMDA receptor-regulated gene protein 2 C-terminus//ADAM cysteine-rich//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//CHDNT (NUC034) domain GO:0006355//GO:0006260//GO:0006508 regulation of transcription, DNA-templated//DNA replication//proteolysis GO:0005524//GO:0004222//GO:0003677//GO:0008134//GO:0008270//GO:0097159//GO:0016887//GO:1901363//GO:0016818 ATP binding//metalloendopeptidase activity//DNA binding//transcription factor binding//zinc ion binding//organic cyclic compound binding//ATPase activity//heterocyclic compound binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0008023//GO:0005634//GO:0005667 transcription elongation factor complex//nucleus//transcription factor complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.2373 BP_3 8.00 0.57 970 607354071 EZA48738.1 309 9.3e-26 hypothetical protein X777_13150 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03791//PF01498 KNOX2 domain//Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.23732 BP_3 163.81 1.62 5167 270004843 EFA01291.1 3798 0.0e+00 cubitus interruptus [Tribolium castaneum] 170028989 XM_001842325.1 250 2.49484e-125 Culex quinquefasciatus cubitus interruptus, mRNA K16799 CI transcriptional activator cubitus interruptus http://www.genome.jp/dbget-bin/www_bget?ko:K16799 P19538 1162 2.5e-125 Transcriptional activator cubitus interruptus OS=Drosophila melanogaster GN=ci PE=1 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.23736 BP_3 862.56 37.86 1390 91091102 XP_968698.1 1218 5.3e-131 PREDICTED: PDZ domain-containing protein GIPC3 [Tribolium castaneum]>gi|270013145|gb|EFA09593.1| hypothetical protein TcasGA2_TC011711 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14908 775 5.1e-81 PDZ domain-containing protein GIPC1 OS=Homo sapiens GN=GIPC1 PE=1 SV=2 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3938 RGS-GAIP interacting protein GIPC, contains PDZ domain Cluster-8309.23737 BP_3 462.37 2.00 11454 642929737 XP_008195956.1 3594 0.0e+00 PREDICTED: zinc finger SWIM domain-containing protein 6-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P217 2085 5.2e-232 Zinc finger SWIM domain-containing protein 5 OS=Homo sapiens GN=ZSWIM5 PE=2 SV=2 PF01189//PF00270//PF00570//PF02861//PF04851//PF02724//PF02892//PF09382//PF05063 16S rRNA methyltransferase RsmF//DEAD/DEAH box helicase//HRDC domain//Clp amino terminal domain, pathogenicity island component//Type III restriction enzyme, res subunit//CDC45-like protein//BED zinc finger//RQC domain//MT-A70 GO:0006281//GO:0006139//GO:0006270//GO:0019538//GO:0006260 DNA repair//nucleobase-containing compound metabolic process//DNA replication initiation//protein metabolic process//DNA replication GO:0003677//GO:0016787//GO:0005524//GO:0043140//GO:0003676//GO:0008168 DNA binding//hydrolase activity//ATP binding//ATP-dependent 3'-5' DNA helicase activity//nucleic acid binding//methyltransferase activity GO:0005657//GO:0005622 replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.23739 BP_3 102.99 0.68 7545 642929737 XP_008195956.1 3594 0.0e+00 PREDICTED: zinc finger SWIM domain-containing protein 6-like isoform X3 [Tribolium castaneum] 642929732 XM_008197732.1 1138 0 PREDICTED: Tribolium castaneum zinc finger SWIM domain-containing protein 6-like (LOC664434), transcript variant X1, mRNA -- -- -- -- Q9P217 2085 3.4e-232 Zinc finger SWIM domain-containing protein 5 OS=Homo sapiens GN=ZSWIM5 PE=2 SV=2 PF04434//PF02861//PF05063//PF01189 SWIM zinc finger//Clp amino terminal domain, pathogenicity island component//MT-A70//16S rRNA methyltransferase RsmF GO:0006139//GO:0019538 nucleobase-containing compound metabolic process//protein metabolic process GO:0008168//GO:0008270 methyltransferase activity//zinc ion binding -- -- KOG3615 Uncharacterized conserved protein Cluster-8309.23740 BP_3 7.62 0.38 1270 332374592 AEE62437.1 485 4.8e-46 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 250 3.5e-20 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.23741 BP_3 7.56 0.40 1192 478250650 ENN71142.1 634 2.4e-63 hypothetical protein YQE_12073, partial [Dendroctonus ponderosae] -- -- -- -- -- K00803 AGPS, agpS alkyldihydroxyacetonephosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00803 Q9V778 451 1.6e-43 Alkyldihydroxyacetonephosphate synthase OS=Drosophila melanogaster GN=CG10253 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1233 Alkyl-dihydroxyacetonephosphate synthase Cluster-8309.23742 BP_3 442.00 5.62 4084 189241592 XP_971198.2 1208 2.2e-129 PREDICTED: serine/threonine-protein kinase 11-interacting protein [Tribolium castaneum]>gi|270001054|gb|EEZ97501.1| hypothetical protein TcasGA2_TC011344 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F479 472 2.0e-45 Serine/threonine-protein kinase 11-interacting protein OS=Gallus gallus GN=STK11IP PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG1859 Leucine-rich repeat proteins Cluster-8309.23743 BP_3 133.14 2.23 3173 642912878 XP_971323.2 692 1.2e-69 PREDICTED: EP300-interacting inhibitor of differentiation 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXX6 191 6.0e-13 Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens GN=NSMCE4A PE=1 SV=2 PF00790 VHS domain GO:0006886 intracellular protein transport -- -- -- -- KOG2866 Uncharacterized conserved protein Cluster-8309.23744 BP_3 9.00 3.24 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23746 BP_3 412.00 4.92 4324 642924359 XP_008194264.1 492 2.5e-46 PREDICTED: uncharacterized protein DDB_G0274915 [Tribolium castaneum]>gi|270006806|gb|EFA03254.1| hypothetical protein TcasGA2_TC013188 [Tribolium castaneum] -- -- -- -- -- K14307 NUPL1, NUP49 nucleoporin p58/p45 http://www.genome.jp/dbget-bin/www_bget?ko:K14307 Q9VDV3 206 1.5e-14 Probable nucleoporin Nup58 OS=Drosophila melanogaster GN=Nup58 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0845 Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) Cluster-8309.23753 BP_3 109.36 1.64 3506 642936026 XP_008198274.1 900 9.9e-94 PREDICTED: ras-related protein Rab-37-like isoform X4 [Tribolium castaneum] 620970185 XM_001514705.3 39 3.32218e-08 PREDICTED: Ornithorhynchus anatinus ras-related protein Rab-39B (LOC100084248), mRNA K07914 RAB37 Ras-related protein Rab-37 http://www.genome.jp/dbget-bin/www_bget?ko:K07914 Q96AX2 733 9.5e-76 Ras-related protein Rab-37 OS=Homo sapiens GN=RAB37 PE=1 SV=3 PF03193//PF00503//PF00071//PF04670//PF08477//PF07728//PF01926//PF07475//PF00025//PF02421 Protein of unknown function, DUF258//G-protein alpha subunit//Ras family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//50S ribosome-binding GTPase//HPr Serine kinase C-terminal domain//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0000160//GO:0007165//GO:0006109//GO:0007186//GO:0015684//GO:0016310//GO:0007264 phosphorelay signal transduction system//signal transduction//regulation of carbohydrate metabolic process//G-protein coupled receptor signaling pathway//ferrous iron transport//phosphorylation//small GTPase mediated signal transduction GO:0031683//GO:0000155//GO:0005524//GO:0003924//GO:0019001//GO:0016887//GO:0015093//GO:0004871//GO:0005525//GO:0004672 G-protein beta/gamma-subunit complex binding//phosphorelay sensor kinase activity//ATP binding//GTPase activity//guanyl nucleotide binding//ATPase activity//ferrous iron transmembrane transporter activity//signal transducer activity//GTP binding//protein kinase activity GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.2376 BP_3 1.00 0.73 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23761 BP_3 1.00 1.14 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23762 BP_3 1.00 7.28 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23765 BP_3 15.00 3.68 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23767 BP_3 1026.99 11.23 4698 546680189 ERL90517.1 2265 7.0e-252 hypothetical protein D910_07865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q15643 640 7.7e-65 Thyroid receptor-interacting protein 11 OS=Homo sapiens GN=TRIP11 PE=1 SV=3 PF01465//PF05440 GRIP domain//Tetrahydromethanopterin S-methyltransferase subunit B GO:0015948//GO:0000042//GO:0046656 methanogenesis//protein targeting to Golgi//folic acid biosynthetic process GO:0030269//GO:0005515 tetrahydromethanopterin S-methyltransferase activity//protein binding GO:0016021 integral component of membrane KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.23768 BP_3 1260.17 13.07 4940 478263926 ENN82092.1 3330 0.0e+00 hypothetical protein YQE_01525, partial [Dendroctonus ponderosae] -- -- -- -- -- K06111 EXOC4, SEC8L1 exocyst complex component 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06111 Q96A65 1435 5.3e-157 Exocyst complex component 4 OS=Homo sapiens GN=EXOC4 PE=1 SV=1 PF00326//PF08702//PF10392//PF07859//PF04048 Prolyl oligopeptidase family//Fibrinogen alpha/beta chain family//Golgi transport complex subunit 5//alpha/beta hydrolase fold//Sec8 exocyst complex component specific domain GO:0015031//GO:0006508//GO:0030168//GO:0006904//GO:0051258//GO:0008152//GO:0007165//GO:0006891 protein transport//proteolysis//platelet activation//vesicle docking involved in exocytosis//protein polymerization//metabolic process//signal transduction//intra-Golgi vesicle-mediated transport GO:0008236//GO:0030674//GO:0005102//GO:0016787 serine-type peptidase activity//protein binding, bridging//receptor binding//hydrolase activity GO:0005577//GO:0017119//GO:0000145 fibrinogen complex//Golgi transport complex//exocyst -- -- Cluster-8309.2377 BP_3 3.00 0.62 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23770 BP_3 159.24 1.37 5891 91090340 XP_967097.1 1485 2.4e-161 PREDICTED: hexosaminidase D [Tribolium castaneum]>gi|270013820|gb|EFA10268.1| hypothetical protein TcasGA2_TC012468 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 525 2.1e-51 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 -- -- GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- -- -- Cluster-8309.23771 BP_3 175.09 1.63 5464 642936176 XP_008198328.1 1213 7.8e-130 PREDICTED: fibronectin type III domain-containing protein 4 [Tribolium castaneum] 194880702 XM_001974468.1 91 6.44308e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF00041//PF16656//PF08022 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//FAD-binding domain GO:0055114//GO:0019497//GO:0006771 oxidation-reduction process//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0016491//GO:0005515//GO:0003993 metal ion binding//oxidoreductase activity//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.23772 BP_3 75.11 1.02 3839 817051906 XP_012253468.1 1791 5.2e-197 PREDICTED: autophagy-related protein 16-1 isoform X2 [Athalia rosae] -- -- -- -- -- K17890 ATG16L autophagy-related protein 16, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K17890 Q676U5 920 2.1e-97 Autophagy-related protein 16-1 OS=Homo sapiens GN=ATG16L1 PE=1 SV=2 PF08702//PF00400//PF00105//PF05837 Fibrinogen alpha/beta chain family//WD domain, G-beta repeat//Zinc finger, C4 type (two domains)//Centromere protein H (CENP-H) GO:0030168//GO:0006355//GO:0051258//GO:0007165//GO:0051382 platelet activation//regulation of transcription, DNA-templated//protein polymerization//signal transduction//kinetochore assembly GO:0003700//GO:0005102//GO:0043565//GO:0030674//GO:0008270//GO:0005515 transcription factor activity, sequence-specific DNA binding//receptor binding//sequence-specific DNA binding//protein binding, bridging//zinc ion binding//protein binding GO:0005577//GO:0000776//GO:0005667//GO:0005634 fibrinogen complex//kinetochore//transcription factor complex//nucleus KOG0288 WD40 repeat protein TipD Cluster-8309.23773 BP_3 117.59 2.19 2877 642930890 XP_008196128.1 328 1.7e-27 PREDICTED: protein-methionine sulfoxide oxidase MICAL3 isoform X8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 208 5.8e-15 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23778 BP_3 163.04 3.49 2543 642935733 XP_008198149.1 467 1.2e-43 PREDICTED: proteoglycan 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03127//PF00010 GAT domain//Helix-loop-helix DNA-binding domain GO:0006886 intracellular protein transport GO:0046983 protein dimerization activity GO:0005622 intracellular -- -- Cluster-8309.2378 BP_3 7.00 1.23 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23782 BP_3 135.81 2.32 3117 332376603 AEE63441.1 1462 6.0e-159 unknown [Dendroctonus ponderosae]>gi|478266236|gb|ENN82734.1| hypothetical protein YQE_00898, partial [Dendroctonus ponderosae]>gi|478269355|gb|ENN83336.1| hypothetical protein YQE_00305, partial [Dendroctonus ponderosae]>gi|546686950|gb|ERL95923.1| hypothetical protein D910_00603 [Dendroctonus ponderosae]>gi|546687121|gb|ERL96001.1| hypothetical protein D910_00781 [Dendroctonus ponderosae]>gi|546687373|gb|ERL96110.1| hypothetical protein D910_01059 [Dendroctonus ponderosae] -- -- -- -- -- K18173 COA1 cytochrome c oxidase assembly factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18173 Q49LS4 393 2.2e-36 XK-related protein 4 OS=Pan troglodytes GN=XKR4 PE=2 SV=1 PF09815//PF01964//PF08294 XK-related protein//Radical SAM ThiC family//TIM21 GO:0009228//GO:0030150 thiamine biosynthetic process//protein import into mitochondrial matrix GO:0051536 iron-sulfur cluster binding GO:0005744//GO:0016021 mitochondrial inner membrane presequence translocase complex//integral component of membrane -- -- Cluster-8309.23783 BP_3 322.07 5.37 3182 332376603 AEE63441.1 1462 6.1e-159 unknown [Dendroctonus ponderosae]>gi|478266236|gb|ENN82734.1| hypothetical protein YQE_00898, partial [Dendroctonus ponderosae]>gi|478269355|gb|ENN83336.1| hypothetical protein YQE_00305, partial [Dendroctonus ponderosae]>gi|546686950|gb|ERL95923.1| hypothetical protein D910_00603 [Dendroctonus ponderosae]>gi|546687121|gb|ERL96001.1| hypothetical protein D910_00781 [Dendroctonus ponderosae]>gi|546687373|gb|ERL96110.1| hypothetical protein D910_01059 [Dendroctonus ponderosae] -- -- -- -- -- K18173 COA1 cytochrome c oxidase assembly factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18173 Q49LS4 393 2.3e-36 XK-related protein 4 OS=Pan troglodytes GN=XKR4 PE=2 SV=1 PF09815//PF08294//PF01964 XK-related protein//TIM21//Radical SAM ThiC family GO:0009228//GO:0030150 thiamine biosynthetic process//protein import into mitochondrial matrix GO:0051536 iron-sulfur cluster binding GO:0005744//GO:0016021 mitochondrial inner membrane presequence translocase complex//integral component of membrane -- -- Cluster-8309.23786 BP_3 14.40 1.20 870 478257946 ENN78084.1 540 1.4e-52 hypothetical protein YQE_05238, partial [Dendroctonus ponderosae] 556999212 XM_006002594.1 131 5.76839e-60 PREDICTED: Latimeria chalumnae RAB2A, member RAS oncogene family (RAB2A), mRNA K07877 RAB2A Ras-related protein Rab-2A http://www.genome.jp/dbget-bin/www_bget?ko:K07877 Q90965 526 2.4e-52 Ras-related protein Rab-2A OS=Gallus gallus GN=RAB2A PE=2 SV=1 PF04670//PF00025//PF00071//PF01926//PF08477 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.23788 BP_3 8.00 0.42 1219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23791 BP_3 146.61 1.34 5571 657571509 XP_008289328.1 264 8.8e-20 PREDICTED: uncharacterized protein LOC103364096, partial [Stegastes partitus] 642937236 XM_008200529.1 145 6.29704e-67 PREDICTED: Tribolium castaneum zinc finger protein 1 (LOC100141776), transcript variant X4, mRNA K09299 ZEB1_2 zinc finger homeobox protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K09299 Q03936 256 3.1e-20 Zinc finger protein 92 OS=Homo sapiens GN=ZNF92 PE=2 SV=2 PF13912//PF05920//PF00096//PF13465//PF00046//PF01155 C2H2-type zinc finger//Homeobox KN domain//Zinc finger, C2H2 type//Zinc-finger double domain//Homeobox domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006355 cellular protein modification process//regulation of transcription, DNA-templated GO:0016151//GO:0046872//GO:0003677 nickel cation binding//metal ion binding//DNA binding -- -- -- -- Cluster-8309.23792 BP_3 38.00 4.25 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23793 BP_3 164.00 10.18 1068 642923459 XP_008193754.1 209 4.0e-14 PREDICTED: uncharacterized protein LOC100142497 isoform X1 [Tribolium castaneum]>gi|270007012|gb|EFA03460.1| hypothetical protein TcasGA2_TC013455 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606 Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23794 BP_3 164.00 7.56 1337 91092772 XP_973748.1 708 6.9e-72 PREDICTED: R3H domain-containing protein 4 [Tribolium castaneum]>gi|270014788|gb|EFA11236.1| hypothetical protein TcasGA2_TC010768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KIL7 213 7.1e-16 R3H domain-containing protein 4 OS=Bos taurus GN=R3HDM4 PE=2 SV=1 PF09171//PF01424 Domain of unknown function (DUF1886)//R3H domain GO:0006284 base-excision repair GO:0016799//GO:0003676//GO:0003906 hydrolase activity, hydrolyzing N-glycosyl compounds//nucleic acid binding//DNA-(apurinic or apyrimidinic site) lyase activity -- -- -- -- Cluster-8309.23798 BP_3 467.00 32.94 975 91084821 XP_973367.1 326 1.0e-27 PREDICTED: methylated-DNA--protein-cysteine methyltransferase [Tribolium castaneum]>gi|270008961|gb|EFA05409.1| hypothetical protein TcasGA2_TC015585 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26189 247 6.0e-20 Regulatory protein ada OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=ada PE=3 SV=2 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain GO:0006281 DNA repair GO:0003824 catalytic activity -- -- KOG4062 6-O-methylguanine-DNA methyltransferase MGMT/MGT1, involved in DNA repair Cluster-8309.23799 BP_3 598.68 23.10 1541 189241005 XP_969371.2 1128 1.6e-120 PREDICTED: polymerase delta-interacting protein 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY77 183 2.5e-12 Polymerase delta-interacting protein 3 OS=Homo sapiens GN=POLDIP3 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.2380 BP_3 109.00 1.48 3830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23800 BP_3 681.11 10.26 3491 642924747 XP_008194424.1 4197 0.0e+00 PREDICTED: tyrosine-protein kinase PR2 isoform X3 [Tribolium castaneum] 462376521 APGK01023661.1 50 2.53908e-14 Dendroctonus ponderosae Seq01023671, whole genome shotgun sequence -- -- -- -- Q9I7F7 1702 4.1e-188 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF07714//PF00069//PF14604//PF00018//PF03943 Protein tyrosine kinase//Protein kinase domain//Variant SH3 domain//SH3 domain//TAP C-terminal domain GO:0051028//GO:0006468 mRNA transport//protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding GO:0005634 nucleus KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.23803 BP_3 30.43 0.43 3718 91082339 XP_966549.1 5059 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC2 [Tribolium castaneum]>gi|270007487|gb|EFA03935.1| hypothetical protein TcasGA2_TC014075 [Tribolium castaneum] 719740584 XM_010211158.1 111 3.33118e-48 PREDICTED: Tinamus guttatus DNA-directed RNA polymerase III subunit RPC2 (LOC104564515), partial mRNA K03021 RPC2, POLR3B DNA-directed RNA polymerase III subunit RPC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03021 Q10233 3370 0.0e+00 DNA-directed RNA polymerase III subunit RPC2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpc2 PE=2 SV=1 PF04561//PF04567//PF04563//PF00562//PF04560//PF04565//PF04566 RNA polymerase Rpb2, domain 2//RNA polymerase Rpb2, domain 5//RNA polymerase beta subunit//RNA polymerase Rpb2, domain 6//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 3//RNA polymerase Rpb2, domain 4 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0032549 DNA-directed RNA polymerase activity//DNA binding//ribonucleoside binding GO:0005730 nucleolus KOG0215 RNA polymerase III, second largest subunit Cluster-8309.23804 BP_3 41.00 0.77 2867 270007440 EFA03888.1 1408 1.0e-152 hypothetical protein TcasGA2_TC014012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03632 Glycosyl hydrolase family 65 central catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.23805 BP_3 2.00 0.33 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23808 BP_3 14.11 1.00 971 861609140 KMQ84926.1 715 7.8e-73 isoform g [Lasius niger] 268574973 XM_002642420.1 86 6.69808e-35 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 602 4.1e-61 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF01517//PF03938//PF16326//PF04111//PF00769//PF01496 Hepatitis delta virus delta antigen//Outer membrane protein (OmpH-like)//ABC transporter C-terminal domain//Autophagy protein Apg6//Ezrin/radixin/moesin family//V-type ATPase 116kDa subunit family GO:0015991//GO:0006914//GO:0015992 ATP hydrolysis coupled proton transport//autophagy//proton transport GO:0003677//GO:0003723//GO:0008092//GO:0015078//GO:0051082 DNA binding//RNA binding//cytoskeletal protein binding//hydrogen ion transmembrane transporter activity//unfolded protein binding GO:0042025//GO:0019898//GO:0005737//GO:0033179 host cell nucleus//extrinsic component of membrane//cytoplasm//proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.23809 BP_3 85.27 0.94 4684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23811 BP_3 10.77 2.83 475 332372484 AEE61384.1 647 2.9e-65 unknown [Dendroctonus ponderosae]>gi|478263185|gb|ENN81578.1| hypothetical protein YQE_02107, partial [Dendroctonus ponderosae]>gi|546681813|gb|ERL91839.1| hypothetical protein D910_09164 [Dendroctonus ponderosae] -- -- -- -- -- K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00508 545 8.1e-55 Aspartate aminotransferase, mitochondrial OS=Gallus gallus GN=GOT2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.23812 BP_3 18.79 0.45 2298 805784346 XP_012140054.1 377 2.9e-33 PREDICTED: DNA primase large subunit-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q84WJ2 220 1.9e-16 Probable DNA primase large subunit OS=Arabidopsis thaliana GN=At1g67320 PE=2 SV=2 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896 DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.23815 BP_3 4.00 1.19 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23816 BP_3 2164.21 12.53 8614 560135523 CDJ84245.1 2272 2.0e-252 Protein of unknown function DUF889 domain containing protein [Haemonchus contortus] -- -- -- -- -- -- -- -- -- Q7ZV90 255 6.2e-20 ATP-dependent DNA helicase PIF1 OS=Danio rerio GN=pif1 PE=2 SV=1 PF05970//PF01443//PF02689 PIF1-like helicase//Viral (Superfamily 1) RNA helicase//Helicase GO:0006281//GO:0000723 DNA repair//telomere maintenance GO:0005524//GO:0003678//GO:0004386 ATP binding//DNA helicase activity//helicase activity GO:0005657 replication fork -- -- Cluster-8309.23818 BP_3 20.93 0.73 1679 160333785 NP_001103903.1 1300 2.0e-140 chitin deacetylase 4 precursor [Tribolium castaneum]>gi|158562480|gb|ABW74146.1| chitin deacetylase 4 [Tribolium castaneum]>gi|270005565|gb|EFA02013.1| hypothetical protein TcasGA2_TC007635 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0005975//GO:0006807//GO:0006030 carbohydrate metabolic process//nitrogen compound metabolic process//chitin metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.2382 BP_3 54.00 1.69 1828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23820 BP_3 415.00 2.92 7140 642935193 XP_008199686.1 2675 3.0e-299 PREDICTED: ATP-dependent RNA helicase abstrakt [Tribolium castaneum] 665786806 XM_008556015.1 412 0 PREDICTED: Microplitis demolitor ATP-dependent RNA helicase abstrakt (LOC103575994), mRNA K13116 DDX41, ABS ATP-dependent RNA helicase DDX41 http://www.genome.jp/dbget-bin/www_bget?ko:K13116 Q9V3C0 2220 7.2e-248 ATP-dependent RNA helicase abstrakt OS=Drosophila melanogaster GN=abs PE=1 SV=1 PF00098//PF11789//PF00096//PF01805//PF06862//PF04851//PF06220//PF00270 Zinc knuckle//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C2H2 type//Surp module//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//Type III restriction enzyme, res subunit//U1 zinc finger//DEAD/DEAH box helicase GO:0006396 RNA processing GO:0046872//GO:0008270//GO:0003676//GO:0005524//GO:0003723//GO:0016787//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//ATP binding//RNA binding//hydrolase activity//DNA binding GO:0005634 nucleus KOG0341 DEAD-box protein abstrakt Cluster-8309.23821 BP_3 932.19 5.79 8054 91080871 XP_972325.1 2663 8.4e-298 PREDICTED: nidogen-1 [Tribolium castaneum]>gi|270005920|gb|EFA02368.1| hypothetical protein TcasGA2_TC008043 [Tribolium castaneum] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 4.0e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF07645//PF00008//PF01731//PF06119 Calcium-binding EGF domain//EGF-like domain//Arylesterase//Nidogen-like GO:0007160 cell-matrix adhesion GO:0005509//GO:0004064//GO:0005515 calcium ion binding//arylesterase activity//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.23822 BP_3 483.63 5.04 4913 642916006 XP_008190854.1 2795 0.0e+00 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23823 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23825 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23830 BP_3 72.96 0.82 4568 642918367 XP_008200036.1 2521 1.4e-281 PREDICTED: titin-like isoform X1 [Tribolium castaneum] 462348959 APGK01033436.1 65 1.52779e-22 Dendroctonus ponderosae Seq01033446, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23832 BP_3 71.00 5.97 865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23833 BP_3 50.00 1.26 2201 642931027 XP_008196184.1 549 3.1e-53 PREDICTED: uncharacterized protein LOC103313791 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8X679 285 5.3e-24 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis briggsae GN=siah-1 PE=3 SV=2 PF02176//PF07967//PF03145 TRAF-type zinc finger//C3HC zinc finger-like//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.23835 BP_3 287.95 3.51 4248 642919707 XP_008192031.1 344 3.6e-29 PREDICTED: cleavage and polyadenylation specificity factor subunit CG7185 [Tribolium castaneum] -- -- -- -- -- K14398 CPSF6_7 cleavage and polyadenylation specificity factor subunit 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14398 Q9VSH4 312 7.5e-27 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4849 mRNA cleavage factor I subunit/CPSF subunit Cluster-8309.23836 BP_3 14.22 0.70 1265 270015414 EFA11862.1 319 8.4e-27 hypothetical protein TcasGA2_TC005104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04048 Sec8 exocyst complex component specific domain GO:0006904//GO:0015031 vesicle docking involved in exocytosis//protein transport -- -- GO:0000145 exocyst -- -- Cluster-8309.23838 BP_3 42.00 1.65 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23839 BP_3 43.00 0.99 2375 288816877 ADC55251.1 2552 1.8e-285 mitochondrial ATP synthase subunit alpha precursor [Litopenaeus vannamei] 327204527 GQ848643.3 1083 0 Litopenaeus vannamei mitochondrial ATP synthase subunit alpha precursor, mRNA, complete cds; nuclear gene for mitochondrial product K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 P35381 2290 1.8e-256 ATP synthase subunit alpha, mitochondrial OS=Drosophila melanogaster GN=blw PE=1 SV=2 PF00306//PF00006//PF02874 ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta family, beta-barrel domain GO:0046034//GO:0015992//GO:0015991 ATP metabolic process//proton transport//ATP hydrolysis coupled proton transport GO:0016820//GO:0005524 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//ATP binding GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-8309.23841 BP_3 13.79 1.12 885 642924004 XP_008193965.1 253 2.6e-19 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23842 BP_3 28.00 0.51 2946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06072//PF11815 Alphaherpesvirus tegument protein US9//Domain of unknown function (DUF3336) GO:0046486//GO:0006629//GO:0016042 glycerolipid metabolic process//lipid metabolic process//lipid catabolic process GO:0004806 triglyceride lipase activity GO:0019033 viral tegument -- -- Cluster-8309.23844 BP_3 2366.70 32.54 3797 642932696 XP_008196948.1 1875 9.4e-207 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10473//PF17085//PF06371//PF06367//PF02183 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Unique cartilage matrix associated protein//Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain//Homeobox associated leucine zipper GO:0030036//GO:0006355//GO:0016043//GO:0045667 actin cytoskeleton organization//regulation of transcription, DNA-templated//cellular component organization//regulation of osteoblast differentiation GO:0003700//GO:0017048//GO:0042803//GO:0043565//GO:0045502//GO:0003779//GO:0008134 transcription factor activity, sequence-specific DNA binding//Rho GTPase binding//protein homodimerization activity//sequence-specific DNA binding//dynein binding//actin binding//transcription factor binding GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.23846 BP_3 156.24 7.02 1365 91080473 XP_970438.1 562 6.0e-55 PREDICTED: mitochondrial inner membrane protease subunit 1 [Tribolium castaneum]>gi|270005561|gb|EFA02009.1| hypothetical protein TcasGA2_TC007631 [Tribolium castaneum] -- -- -- -- -- K09647 IMP1 mitochondrial inner membrane protease subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09647 Q96LU5 398 2.6e-37 Mitochondrial inner membrane protease subunit 1 OS=Homo sapiens GN=IMMP1L PE=2 SV=1 -- -- GO:0006508 proteolysis GO:0008236 serine-type peptidase activity GO:0016021 integral component of membrane KOG0171 Mitochondrial inner membrane protease, subunit IMP1 Cluster-8309.23849 BP_3 11.17 0.69 1072 91090252 XP_969934.1 319 7.1e-27 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 A6QPI6 199 2.4e-14 Mitochondrial import receptor subunit TOM22 homolog OS=Bos taurus GN=TOMM22 PE=2 SV=1 PF04281//PF02554//PF00060 Mitochondrial import receptor subunit Tom22//Carbon starvation protein CstA//Ligand-gated ion channel GO:0009267//GO:0006811//GO:0007165//GO:0007268//GO:0006886 cellular response to starvation//ion transport//signal transduction//synaptic transmission//intracellular protein transport GO:0004970 ionotropic glutamate receptor activity GO:0005741//GO:0016020 mitochondrial outer membrane//membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.23850 BP_3 48.65 10.59 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23853 BP_3 126.00 5.59 1378 733929037 XP_010725335.1 174 6.0e-10 PREDICTED: mucin-21-like [Meleagris gallopavo] -- -- -- -- -- -- -- -- -- P40954 130 3.1e-06 Chitinase 3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CHT3 PE=1 SV=2 PF01442//PF06426 Apolipoprotein A1/A4/E domain//Serine acetyltransferase, N-terminal GO:0042967//GO:0006534//GO:0006869//GO:0042157//GO:0006535 acyl-carrier-protein biosynthetic process//cysteine metabolic process//lipid transport//lipoprotein metabolic process//cysteine biosynthetic process from serine GO:0008289//GO:0009001 lipid binding//serine O-acetyltransferase activity GO:0005737//GO:0005576 cytoplasm//extracellular region -- -- Cluster-8309.23854 BP_3 389.94 31.10 896 332376162 AEE63221.1 792 8.4e-82 unknown [Dendroctonus ponderosae]>gi|478261356|gb|ENN80760.1| hypothetical protein YQE_02821, partial [Dendroctonus ponderosae]>gi|546678771|gb|ERL89323.1| hypothetical protein D910_06695 [Dendroctonus ponderosae] -- -- -- -- -- K05756 ARPC3 actin related protein 2/3 complex, subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05756 Q9JM76 631 1.6e-64 Actin-related protein 2/3 complex subunit 3 OS=Mus musculus GN=Arpc3 PE=1 SV=3 PF04062 ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0005885//GO:0005856 Arp2/3 protein complex//cytoskeleton KOG3155 Actin-related protein Arp2/3 complex, subunit ARPC3 Cluster-8309.23855 BP_3 8.76 0.32 1618 189233697 XP_966459.2 731 1.8e-74 PREDICTED: uncharacterized protein C17orf59 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D6W8 170 8.4e-11 Uncharacterized protein C17orf59 homolog OS=Mus musculus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23857 BP_3 27.59 0.79 1977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23858 BP_3 77.51 0.51 7587 189241213 XP_970686.2 2041 1.1e-225 PREDICTED: peroxisomal targeting signal 1 receptor isoform X1 [Tribolium castaneum]>gi|270013260|gb|EFA09708.1| hypothetical protein TcasGA2_TC011841 [Tribolium castaneum] 462302391 APGK01050245.1 50 5.54675e-14 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1125 7.2e-121 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF00638//PF02064//PF13181//PF13371//PF00515//PF13374//PF00400//PF13176//PF13414 RanBP1 domain//MAS20 protein import receptor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//TPR repeat GO:0006886//GO:0046907//GO:0006605 intracellular protein transport//intracellular transport//protein targeting GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.23859 BP_3 26.43 0.52 2743 91089737 XP_975124.1 1653 3.8e-181 PREDICTED: protein RFT1 homolog [Tribolium castaneum]>gi|270011306|gb|EFA07754.1| hypothetical protein TcasGA2_TC005308 [Tribolium castaneum] -- -- -- -- -- K06316 RFT1 oligosaccharide translocation protein RFT1 http://www.genome.jp/dbget-bin/www_bget?ko:K06316 Q9Y123 1075 1.6e-115 Protein RFT1 homolog OS=Drosophila melanogaster GN=CG3149 PE=2 SV=1 PF01384//PF04506//PF09515//PF02554 Phosphate transporter family//Rft protein//Thiamine transporter protein (Thia_YuaJ)//Carbon starvation protein CstA GO:0006869//GO:0006817//GO:0009267//GO:0015888 lipid transport//phosphate ion transport//cellular response to starvation//thiamine transport GO:0005319//GO:0015234//GO:0005315 lipid transporter activity//thiamine transmembrane transporter activity//inorganic phosphate transmembrane transporter activity GO:0016021//GO:0005886//GO:0016020 integral component of membrane//plasma membrane//membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.23862 BP_3 70.18 0.86 4207 478250569 ENN71062.1 1077 3.6e-114 hypothetical protein YQE_12246, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96MR6 490 1.7e-47 Cilia- and flagella-associated protein 57 OS=Homo sapiens GN=CFAP57 PE=2 SV=3 PF07989//PF10473//PF08702//PF17060//PF04977//PF06156//PF00170//PF02732 Centrosomin N-terminal motif 1//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Fibrinogen alpha/beta chain family//Monopolar spindle protein 2//Septum formation initiator//Protein of unknown function (DUF972)//bZIP transcription factor//ERCC4 domain GO:0007049//GO:0006260//GO:0006355//GO:0051258//GO:0007165//GO:0071988//GO:0030168//GO:0030474 cell cycle//DNA replication//regulation of transcription, DNA-templated//protein polymerization//signal transduction//protein localization to spindle pole body//platelet activation//spindle pole body duplication GO:0003700//GO:0005102//GO:0043565//GO:0008134//GO:0045502//GO:0004518//GO:0042803//GO:0030674//GO:0003677 transcription factor activity, sequence-specific DNA binding//receptor binding//sequence-specific DNA binding//transcription factor binding//dynein binding//nuclease activity//protein homodimerization activity//protein binding, bridging//DNA binding GO:0005577//GO:0005815//GO:0005667//GO:0030286 fibrinogen complex//microtubule organizing center//transcription factor complex//dynein complex -- -- Cluster-8309.23864 BP_3 2.52 0.69 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23865 BP_3 8.00 0.61 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23866 BP_3 2139.18 17.99 6023 270000847 EEZ97294.1 1566 1.0e-170 hypothetical protein TcasGA2_TC011099 [Tribolium castaneum] 642937258 XM_008200538.1 171 2.39832e-81 PREDICTED: Tribolium castaneum mucin-2 (LOC657242), mRNA -- -- -- -- -- -- -- -- PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.23871 BP_3 235.94 3.03 4045 642910866 XP_001813884.2 1865 1.4e-205 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1157 7.5e-125 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF00103//PF02390//PF04977//PF08123 Somatotropin hormone family//Putative methyltransferase//Septum formation initiator//Histone methylation protein DOT1 GO:0007165//GO:0006479//GO:0009451//GO:0007049//GO:0006400//GO:0008033//GO:0006554 signal transduction//protein methylation//RNA modification//cell cycle//tRNA modification//tRNA processing//lysine catabolic process GO:0018024//GO:0005179//GO:0008176 histone-lysine N-methyltransferase activity//hormone activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.23873 BP_3 66.95 0.55 6163 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23874 BP_3 361.00 25.47 975 642914664 XP_008190305.1 775 8.6e-80 PREDICTED: peptidyl-prolyl cis-trans isomerase-like 3 [Tribolium castaneum] -- -- -- -- -- K12734 PPIL3 peptidyl-prolyl cis-trans isomerase-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12734 Q9H2H8 720 8.4e-75 Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens GN=PPIL3 PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0884 Similar to cyclophilin-type peptidyl-prolyl cis-trans isomerase Cluster-8309.23878 BP_3 41.60 1.07 2157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04573 Signal peptidase subunit GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.23882 BP_3 17.78 0.32 2961 478254857 ENN75093.1 225 1.6e-15 hypothetical protein YQE_08406, partial [Dendroctonus ponderosae] -- -- -- -- -- K14394 ACP1 low molecular weight phosphotyrosine protein phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14394 P82890 176 3.1e-11 Low molecular weight phosphotyrosine protein phosphatase 1 OS=Drosophila melanogaster GN=primo-1 PE=2 SV=1 PF00961 LAGLIDADG endonuclease -- -- GO:0004519 endonuclease activity -- -- KOG3217 Protein tyrosine phosphatase Cluster-8309.23883 BP_3 579.62 13.02 2437 642928421 XP_008193780.1 3184 0.0e+00 PREDICTED: probable cleavage and polyadenylation specificity factor subunit 2 [Tribolium castaneum]>gi|270010824|gb|EFA07272.1| hypothetical protein TcasGA2_TC014506 [Tribolium castaneum] 665813545 XM_008557111.1 256 5.3972e-129 PREDICTED: Microplitis demolitor probable cleavage and polyadenylation specificity factor subunit 2 (LOC103576746), mRNA K14402 CPSF2, CFT2 cleavage and polyadenylation specificity factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14402 Q9V3D6 2508 9.9e-282 Probable cleavage and polyadenylation specificity factor subunit 2 OS=Drosophila melanogaster GN=Cpsf100 PE=1 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit) Cluster-8309.23884 BP_3 5.00 1.09 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23885 BP_3 44.64 0.90 2676 642921104 XP_008192691.1 1061 1.6e-112 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 499 9.8e-49 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF04882//PF02535//PF09726//PF05279//PF15678 Peroxin-3//ZIP Zinc transporter//Transmembrane protein//Aspartyl beta-hydroxylase N-terminal region//Centriole duplication and mitotic chromosome congression GO:0030001//GO:0007031//GO:0055085//GO:0090307 metal ion transport//peroxisome organization//transmembrane transport//mitotic spindle assembly GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005779//GO:0016021 membrane//integral component of peroxisomal membrane//integral component of membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.23887 BP_3 415.62 7.90 2827 642934418 XP_008197653.1 541 3.4e-52 PREDICTED: transformer-2 protein homolog beta isoform X4 [Tribolium castaneum] 642934415 XM_008199430.1 258 4.84646e-130 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X3, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 2.5e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF00076//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0118 FOG: RRM domain Cluster-8309.2389 BP_3 178.75 4.06 2414 642935066 XP_008197868.1 2073 6.6e-230 PREDICTED: ABC transmembrane transporter white isoform X1 [Tribolium castaneum]>gi|17646397|gb|AAL40947.1| ABC transmembrane transporter [Tribolium castaneum]>gi|270013401|gb|EFA09849.1| hypothetical protein TcasGA2_TC011997 [Tribolium castaneum] 763477791 KM667971.1 97 1.30498e-40 Plutella xylostella strain DBM1Ac-S white protein mRNA, complete cds -- -- -- -- P10090 1673 6.5e-185 Protein white OS=Drosophila melanogaster GN=w PE=2 SV=2 PF00910//PF03193//PF00005//PF01926//PF13304//PF01061 RNA helicase//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC-2 type transporter -- -- GO:0003724//GO:0017111//GO:0016887//GO:0005525//GO:0000166//GO:0003924//GO:0003723//GO:0005524 RNA helicase activity//nucleoside-triphosphatase activity//ATPase activity//GTP binding//nucleotide binding//GTPase activity//RNA binding//ATP binding GO:0016020 membrane -- -- Cluster-8309.23890 BP_3 164.36 3.93 2309 642933530 XP_008197457.1 904 2.2e-94 PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933532|ref|XP_008197458.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933534|ref|XP_008197459.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum] 462283408 APGK01056946.1 55 2.7776e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 6.6e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF07267//PF09726//PF00076 Nucleopolyhedrovirus capsid protein P87//Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4733 FOG: RRM domain Cluster-8309.23894 BP_3 3.00 1.13 419 642924469 XP_008194311.1 355 1.9e-31 PREDICTED: transcription factor Sox-2 [Tribolium castaneum]>gi|270008130|gb|EFA04578.1| Sox21b [Tribolium castaneum] 642924468 XM_008196089.1 169 2.00211e-81 PREDICTED: Tribolium castaneum transcription factor Sox-2 (LOC660661), mRNA K09267 SOX1S transcription factor SOX1/3/14/21 (SOX group B) http://www.genome.jp/dbget-bin/www_bget?ko:K09267 Q24533 177 3.3e-12 SOX domain-containing protein dichaete OS=Drosophila melanogaster GN=D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.23895 BP_3 189.53 0.71 13070 642920697 XP_008192527.1 625 2.9e-61 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202//PF09726//PF04443 Adipogenin//Transmembrane protein//Acyl-protein synthetase, LuxE GO:0045444//GO:0008218 fat cell differentiation//bioluminescence GO:0047474 long-chain fatty acid luciferin component ligase activity GO:0016021 integral component of membrane -- -- Cluster-8309.23896 BP_3 3399.45 13.49 12436 642920697 XP_008192527.1 625 2.7e-61 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04443//PF15202 Acyl-protein synthetase, LuxE//Adipogenin GO:0008218//GO:0045444 bioluminescence//fat cell differentiation GO:0047474 long-chain fatty acid luciferin component ligase activity -- -- -- -- Cluster-8309.23897 BP_3 11096.85 94.39 5958 642920697 XP_008192527.1 407 2.5e-36 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06546 Vertebrate heat shock transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.239 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23901 BP_3 702.41 8.90 4094 642911219 XP_008199637.1 1875 1.0e-206 PREDICTED: FCH domain only protein 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502I9 789 3.5e-82 F-BAR domain only protein 2 OS=Danio rerio GN=fcho2 PE=2 SV=1 PF02662//PF01442//PF13326//PF02050 Methyl-viologen-reducing hydrogenase, delta subunit//Apolipoprotein A1/A4/E domain//Photosystem II Pbs27//Flagellar FliJ protein GO:0055114//GO:0010207//GO:0071973//GO:0006869//GO:0015948//GO:0042157//GO:0006935 oxidation-reduction process//photosystem II assembly//bacterial-type flagellum-dependent cell motility//lipid transport//methanogenesis//lipoprotein metabolic process//chemotaxis GO:0003774//GO:0008289 motor activity//lipid binding GO:0005576//GO:0009288//GO:0016020 extracellular region//bacterial-type flagellum//membrane KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.23902 BP_3 49.15 2.68 1176 817079505 XP_012262173.1 280 2.6e-22 PREDICTED: zinc finger protein 706-like [Athalia rosae]>gi|817079507|ref|XP_012262174.1| PREDICTED: zinc finger protein 706-like [Athalia rosae] 389609616 AK401798.1 81 4.90732e-32 Papilio xuthus mRNA for similar to CG15715, complete cds, sequence id: Px-1382 -- -- -- -- Q5ZMM5 201 1.5e-14 Zinc finger protein 706 OS=Gallus gallus GN=ZNF706 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4118 Uncharacterized conserved protein Cluster-8309.23903 BP_3 9.00 2.00 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23905 BP_3 167.97 62.70 420 270011573 EFA08021.1 284 3.2e-23 hypothetical protein TcasGA2_TC005610 [Tribolium castaneum] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23906 BP_3 388.03 11.35 1939 91088923 XP_973277.1 1071 8.1e-114 PREDICTED: lysophospholipid acyltransferase 7 [Tribolium castaneum] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 Q5U4T9 604 4.7e-61 Lysophospholipid acyltransferase 7 OS=Xenopus laevis GN=mboat7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2706 Predicted membrane protein Cluster-8309.23907 BP_3 246.09 7.13 1956 91088923 XP_973277.1 1071 8.2e-114 PREDICTED: lysophospholipid acyltransferase 7 [Tribolium castaneum] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 Q5U4T9 604 4.8e-61 Lysophospholipid acyltransferase 7 OS=Xenopus laevis GN=mboat7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2706 Predicted membrane protein Cluster-8309.23909 BP_3 100.79 1.46 3618 780649216 XP_011689959.1 1077 3.1e-114 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00589 Phage integrase family GO:0015074//GO:0006310 DNA integration//DNA recombination GO:0003677 DNA binding -- -- -- -- Cluster-8309.2391 BP_3 5.00 1.21 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23912 BP_3 6.00 0.95 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23913 BP_3 532.71 5.89 4651 340717680 XP_003397307.1 2904 0.0e+00 PREDICTED: protein O-GlcNAcase [Bombus terrestris] 830022072 XM_012723671.1 44 7.34144e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 1092 2.9e-117 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 PF00736//PF05418//PF09726 EF-1 guanine nucleotide exchange domain//Apovitellenin I (Apo-VLDL-II)//Transmembrane protein GO:0006414//GO:0006629//GO:0006448 translational elongation//lipid metabolic process//regulation of translational elongation GO:0003746//GO:0004857 translation elongation factor activity//enzyme inhibitor activity GO:0005840//GO:0005853//GO:0042627//GO:0016021 ribosome//eukaryotic translation elongation factor 1 complex//chylomicron//integral component of membrane KOG3698 Hyaluronoglucosaminidase Cluster-8309.23915 BP_3 84.34 0.94 4610 478251870 ENN72309.1 1219 1.3e-130 hypothetical protein YQE_11052, partial [Dendroctonus ponderosae] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 943 5.5e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF14750//PF09445//PF02086//PF02875//PF08241 Integrator complex subunit 2//RNA cap guanine-N2 methyltransferase//D12 class N6 adenine-specific DNA methyltransferase//Mur ligase family, glutamate ligase domain//Methyltransferase domain GO:0006306//GO:0009058//GO:0001510//GO:0009452//GO:0032775//GO:0008152 DNA methylation//biosynthetic process//RNA methylation//7-methylguanosine RNA capping//DNA methylation on adenine//metabolic process GO:0008168//GO:0009007//GO:0005524//GO:0016874 methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//ATP binding//ligase activity GO:0032039 integrator complex KOG2078 tRNA modification enzyme Cluster-8309.23919 BP_3 250.00 20.77 872 642919649 XP_008192006.1 626 1.5e-62 PREDICTED: breast cancer metastasis-suppressor 1-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K19196 BRMS1 breast cancer metastasis-suppressor 1 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K19196 Q5ZLL9 386 4.1e-36 Breast cancer metastasis-suppressor 1-like protein OS=Gallus gallus GN=BRMS1L PE=2 SV=1 PF04546 Sigma-70, non-essential region GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0016987 transcription factor activity, sequence-specific DNA binding//DNA binding//sigma factor activity GO:0005667 transcription factor complex -- -- Cluster-8309.2392 BP_3 4.00 0.31 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23920 BP_3 16.33 0.67 1474 612063312 XP_007505910.1 496 2.9e-47 PREDICTED: zinc finger protein 420-like [Monodelphis domestica] -- -- -- -- -- -- -- -- -- Q6ZMW2 479 1.1e-46 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF04810//PF02892//PF01363//PF13912//PF01428//PF01844//PF16622//PF05191//PF10503//PF13465//PF06467//PF14528//PF00096//PF01155//PF00130 Sec23/Sec24 zinc finger//BED zinc finger//FYVE zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//HNH endonuclease//zinc-finger C2H2-type//Adenylate kinase, active site lid//Esterase PHB depolymerase//Zinc-finger double domain//MYM-type Zinc finger with FCS sequence motif//LAGLIDADG-like domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006886//GO:0006888//GO:0046034//GO:0006144//GO:0006464//GO:0035556 intracellular protein transport//ER to Golgi vesicle-mediated transport//ATP metabolic process//purine nucleobase metabolic process//cellular protein modification process//intracellular signal transduction GO:0016151//GO:0003677//GO:0004519//GO:0046872//GO:0004017//GO:0003676//GO:0008270 nickel cation binding//DNA binding//endonuclease activity//metal ion binding//adenylate kinase activity//nucleic acid binding//zinc ion binding GO:0030127//GO:0005576 COPII vesicle coat//extracellular region -- -- Cluster-8309.23923 BP_3 14.29 0.81 1140 780089478 XP_011673857.1 395 1.2e-35 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 331 1.3e-29 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13411//PF13606//PF05396//PF05155 Ankyrin repeat//MerR HTH family regulatory protein//Ankyrin repeat//Phage T7 capsid assembly protein//Phage X family GO:0019069//GO:0006260//GO:0006355 viral capsid assembly//DNA replication//regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.23925 BP_3 0.39 0.32 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23928 BP_3 80.64 0.79 5235 642922636 XP_971090.3 2290 9.8e-255 PREDICTED: uncharacterized protein LOC659719 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 Q6P7W0 366 5.1e-33 Sentrin-specific protease 6 OS=Mus musculus GN=Senp6 PE=2 SV=3 PF02944//PF02902 BESS motif//Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0003677//GO:0008234 DNA binding//cysteine-type peptidase activity -- -- KOG0779 Protease, Ulp1 family Cluster-8309.23931 BP_3 66.05 2.76 1444 642915229 XP_008190531.1 1280 3.5e-138 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 828 3.7e-87 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF02793//PF13895 Hormone receptor domain//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016020 membrane -- -- Cluster-8309.23932 BP_3 15.92 0.59 1598 642915229 XP_008190531.1 1163 1.4e-124 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 680 6.0e-70 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23933 BP_3 1.40 0.31 511 91080669 XP_975087.1 498 5.9e-48 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 749780830 XM_011146479.1 92 1.57904e-38 PREDICTED: Harpegnathos saltator vesicle-trafficking protein SEC22b (LOC105186349), transcript variant X2, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 372 1.0e-34 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 -- -- GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.23934 BP_3 31.46 0.82 2140 91078844 XP_971675.1 341 4.0e-29 PREDICTED: leucine-rich repeat-containing protein 59 [Tribolium castaneum]>gi|270003717|gb|EFA00165.1| hypothetical protein TcasGA2_TC002987 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NWG1 202 2.2e-14 Leucine-rich repeat-containing protein 59 OS=Danio rerio GN=lrrc59 PE=2 SV=1 PF15715//PF07836 PCNA-associated factor//DmpG-like communication domain GO:0006974//GO:0051726//GO:0019439 cellular response to DNA damage stimulus//regulation of cell cycle//aromatic compound catabolic process GO:0016833 oxo-acid-lyase activity -- -- -- -- Cluster-8309.23936 BP_3 255.54 5.31 2610 642915624 XP_008190712.1 2597 1.2e-290 PREDICTED: protein tramtrack, beta isoform isoform X2 [Tribolium castaneum] 642915623 XM_008192490.1 419 0 PREDICTED: Tribolium castaneum protein tramtrack, beta isoform (LOC660343), transcript variant X4, mRNA -- -- -- -- Q9W0K7 396 8.4e-37 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF05007//PF02796//PF05225//PF00651 Mannosyltransferase (PIG-M)//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//BTB/POZ domain GO:0006506//GO:0006310 GPI anchor biosynthetic process//DNA recombination GO:0005515//GO:0000150//GO:0003677//GO:0016758 protein binding//recombinase activity//DNA binding//transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane -- -- Cluster-8309.23937 BP_3 66.16 0.40 8213 546683888 ERL93636.1 913 7.2e-95 hypothetical protein D910_10924 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NZM4 177 6.6e-11 Glioma tumor suppressor candidate region gene 1 protein OS=Homo sapiens GN=GLTSCR1 PE=1 SV=2 PF00020 TNFR/NGFR cysteine-rich region -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23938 BP_3 8.65 0.36 1453 546679816 ERL90208.1 553 7.1e-54 hypothetical protein D910_07562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 476 2.5e-46 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.23939 BP_3 379.22 3.68 5256 390362249 XP_001190749.2 801 4.5e-82 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 734 1.1e-75 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF06451//PF13606//PF12537//PF00023 Moricin//Ankyrin repeat//The Golgi pH Regulator (GPHR) Family N-terminal//Ankyrin repeat GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0016020//GO:0005576 membrane//extracellular region KOG4177 Ankyrin Cluster-8309.2394 BP_3 1.00 0.35 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23941 BP_3 7.82 0.52 1018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23943 BP_3 10.00 1.57 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23947 BP_3 247.49 2.24 5607 642927835 XP_972081.2 781 1.0e-79 PREDICTED: LOW QUALITY PROTEIN: probable glucosamine 6-phosphate N-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00621 GNPNAT1, GNA1 glucosamine-phosphate N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00621 Q9VAI0 611 2.1e-61 Probable glucosamine 6-phosphate N-acetyltransferase OS=Drosophila melanogaster GN=CG1969 PE=2 SV=1 PF13673//PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3396 Glucosamine-phosphate N-acetyltransferase Cluster-8309.23950 BP_3 41.52 0.37 5667 642915644 XP_972006.3 1939 5.3e-214 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.7e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.23951 BP_3 13.00 2.07 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23952 BP_3 18.91 1.56 876 861633341 KMQ90932.1 264 1.4e-20 transposable element tc3 transposase [Lasius niger]>gi|861638451|gb|KMQ92508.1| transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23953 BP_3 13.00 3.95 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23954 BP_3 39.00 0.99 2187 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23955 BP_3 26.00 0.49 2849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01020 Ribosomal L40e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.23957 BP_3 25.00 3.99 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23960 BP_3 5.00 1.07 516 752863744 XP_011268239.1 257 5.3e-20 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23965 BP_3 3.00 0.91 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23967 BP_3 10.60 0.32 1900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23969 BP_3 31.29 0.65 2615 91077460 XP_967961.1 1258 2.3e-135 PREDICTED: membrane-bound transcription factor site-2 protease [Tribolium castaneum]>gi|270001616|gb|EEZ98063.1| hypothetical protein TcasGA2_TC000469 [Tribolium castaneum] -- -- -- -- -- K07765 MBTPS2 S2P endopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K07765 O54862 544 5.8e-54 Membrane-bound transcription factor site-2 protease OS=Cricetulus griseus GN=MBTPS2 PE=2 SV=1 PF13180//PF02163 PDZ domain//Peptidase family M50 GO:0006508 proteolysis GO:0005515//GO:0004222 protein binding//metalloendopeptidase activity -- -- KOG2921 Intramembrane metalloprotease (sterol-regulatory element-binding protein (SREBP) protease) Cluster-8309.2397 BP_3 164.80 8.93 1181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23970 BP_3 371.96 18.03 1286 91077326 XP_974776.1 1025 1.2e-108 PREDICTED: pyrroline-5-carboxylate reductase 3 [Tribolium castaneum]>gi|270001668|gb|EEZ98115.1| hypothetical protein TcasGA2_TC000533 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q5SPD7 601 7.0e-61 Pyrroline-5-carboxylate reductase 3 OS=Danio rerio GN=pycrl PE=2 SV=1 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006098//GO:0006525//GO:0006561//GO:0019521//GO:0055114 pentose-phosphate shunt//arginine metabolic process//proline biosynthetic process//D-gluconate metabolic process//oxidation-reduction process GO:0004735//GO:0000166//GO:0004616 pyrroline-5-carboxylate reductase activity//nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.23971 BP_3 165.00 4.53 2046 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23974 BP_3 59.69 1.44 2296 91088003 XP_973796.1 525 2.0e-50 PREDICTED: putative RNA-binding protein Luc7-like 2 [Tribolium castaneum]>gi|270011896|gb|EFA08344.1| hypothetical protein TcasGA2_TC005987 [Tribolium castaneum] -- -- -- -- -- K13212 LUC7L2 RNA-binding protein Luc7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13212 Q9Y383 397 5.7e-37 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens GN=LUC7L2 PE=1 SV=2 PF07851//PF03194//PF01442 TMPIT-like protein//LUC7 N_terminus//Apolipoprotein A1/A4/E domain GO:0042157//GO:0006376//GO:0006869 lipoprotein metabolic process//mRNA splice site selection//lipid transport GO:0003729//GO:0008289 mRNA binding//lipid binding GO:0005576//GO:0005685//GO:0016021 extracellular region//U1 snRNP//integral component of membrane KOG0796 Spliceosome subunit Cluster-8309.23975 BP_3 18.95 0.53 2012 478256105 ENN76304.1 228 4.8e-16 hypothetical protein YQE_07267, partial [Dendroctonus ponderosae] 642921924 XM_008194725.1 121 4.93956e-54 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4 gamma 3-like (LOC656935), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF05372 Delta lysin family GO:0019836 hemolysis by symbiont of host erythrocytes -- -- GO:0005576 extracellular region -- -- Cluster-8309.23978 BP_3 415.29 4.83 4435 642914862 XP_008195074.1 2187 7.3e-243 PREDICTED: myosin light chain kinase, smooth muscle-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q28824 825 2.6e-86 Myosin light chain kinase, smooth muscle OS=Bos taurus GN=MYLK PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.23980 BP_3 36.90 0.31 6075 270007165 EFA03613.1 1428 1.0e-154 hypothetical protein TcasGA2_TC013701 [Tribolium castaneum] 642922589 XM_008195018.1 320 3.58938e-164 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X6, mRNA -- -- -- -- P55197 839 8.4e-88 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF15319//PF00628 RAD9, RAD1, HUS1-interacting nuclear orphan protein//PHD-finger GO:0071479//GO:0000077 cellular response to ionizing radiation//DNA damage checkpoint GO:0005515 protein binding GO:0005634 nucleus KOG0956 PHD finger protein AF10 Cluster-8309.23981 BP_3 340.00 8.98 2117 91083793 XP_972792.1 560 1.6e-54 PREDICTED: pre-mRNA-splicing factor CWC25 homolog [Tribolium castaneum]>gi|270006778|gb|EFA03226.1| hypothetical protein TcasGA2_TC013151 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXE8 172 6.4e-11 Pre-mRNA-splicing factor CWC25 homolog OS=Homo sapiens GN=CWC25 PE=1 SV=1 PF04211 Tetrahydromethanopterin S-methyltransferase, subunit C GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane KOG3869 Uncharacterized conserved protein Cluster-8309.23982 BP_3 41.00 3.77 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23983 BP_3 9.56 0.39 1489 642922686 XP_008193280.1 161 2.1e-08 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98165 136 6.8e-07 Very low-density lipoprotein receptor OS=Gallus gallus GN=VLDLR PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.23992 BP_3 25.00 1.62 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23995 BP_3 844.00 13.99 3199 189238859 XP_972488.2 1594 3.0e-174 PREDICTED: regulator of gene activity isoform X1 [Tribolium castaneum] 642927573 XM_967395.3 458 0 PREDICTED: Tribolium castaneum regulator of gene activity (LOC661220), transcript variant X1, mRNA K12605 CNOT2, NOT2 CCR4-NOT transcription complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12605 Q9NZN8 867 2.5e-91 CCR4-NOT transcription complex subunit 2 OS=Homo sapiens GN=CNOT2 PE=1 SV=1 PF04153 NOT2 / NOT3 / NOT5 family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2151 Predicted transcriptional regulator Cluster-8309.24 BP_3 23.00 2.27 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.240 BP_3 294.00 20.35 988 -- -- -- -- -- 728786035 KJ418950.1 176 6.35382e-85 Cryptopygus sverdrupi voucher MNHN:cd461_057 16S ribosomal RNA gene, partial sequence; mitochondrial -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24002 BP_3 64.59 0.77 4356 270012526 EFA08974.1 185 1.0e-10 hypothetical protein TcasGA2_TC006681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24003 BP_3 28.20 0.50 2998 270014457 EFA10905.1 278 1.1e-21 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098//PF07776 C2H2 zinc-finger//Zinc knuckle//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.24005 BP_3 209.17 3.95 2841 642916191 XP_008190924.1 2242 2.0e-249 PREDICTED: uncharacterized protein LOC662537 [Tribolium castaneum] 746862194 XM_011063702.1 155 8.81013e-73 PREDICTED: Acromyrmex echinatior uncharacterized LOC105150543 (LOC105150543), mRNA K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q8VHQ2 432 6.1e-41 Suppressor of cytokine signaling 7 OS=Mus musculus GN=Socs7 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.24006 BP_3 51.48 0.66 4065 642910948 XP_008193477.1 1972 5.7e-218 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 1403 2.2e-153 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF02897//PF00326 Prolyl oligopeptidase, N-terminal beta-propeller domain//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0070008//GO:0008236//GO:0004252 serine-type exopeptidase activity//serine-type peptidase activity//serine-type endopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.24008 BP_3 1874.48 31.22 3186 189236914 XP_969111.2 2409 9.5e-269 PREDICTED: alpha-(1,6)-fucosyltransferase [Tribolium castaneum]>gi|270006336|gb|EFA02784.1| hypothetical protein TcasGA2_TC008521 [Tribolium castaneum] 170044484 XM_001849824.1 190 3.45913e-92 Culex quinquefasciatus alpha-(1,6)-fucosyltransferase, mRNA K00717 FUT8 glycoprotein 6-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00717 Q9VYV5 1615 4.6e-178 Alpha-(1,6)-fucosyltransferase OS=Drosophila melanogaster GN=FucT6 PE=1 SV=1 PF03938//PF14604//PF09807 Outer membrane protein (OmpH-like)//Variant SH3 domain//Elongation complex protein 6 -- -- GO:0005515//GO:0051082 protein binding//unfolded protein binding GO:0033588 Elongator holoenzyme complex KOG3705 Glycoprotein 6-alpha-L-fucosyltransferase Cluster-8309.24009 BP_3 1617.00 39.74 2253 91084147 XP_970126.1 1360 2.9e-147 PREDICTED: decaprenyl-diphosphate synthase subunit 2 [Tribolium castaneum]>gi|642925102|ref|XP_008194170.1| PREDICTED: decaprenyl-diphosphate synthase subunit 2 [Tribolium castaneum]>gi|270008055|gb|EFA04503.1| hypothetical protein TcasGA2_TC014811 [Tribolium castaneum] -- -- -- -- -- K12505 PDSS2 decaprenyl-diphosphate synthase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12505 Q86YH6 453 1.8e-43 Decaprenyl-diphosphate synthase subunit 2 OS=Homo sapiens GN=PDSS2 PE=1 SV=2 PF00348//PF04207 Polyprenyl synthetase//Tetrahydromethanopterin S-methyltransferase, subunit D GO:0006814//GO:0008299//GO:0046656 sodium ion transport//isoprenoid biosynthetic process//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0012506//GO:0005737 vesicle membrane//cytoplasm KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.2401 BP_3 4.00 1.24 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24010 BP_3 17.55 11.15 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24012 BP_3 95.72 2.47 2161 270014464 EFA10912.1 1586 1.7e-173 hypothetical protein TcasGA2_TC001738 [Tribolium castaneum] 805771594 XM_012281304.1 194 1.39562e-94 PREDICTED: Megachile rotundata casein kinase I isoform gamma-3 (LOC100876501), transcript variant X5, mRNA K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q62763 1366 2.3e-149 Casein kinase I isoform gamma-3 OS=Rattus norvegicus GN=Csnk1g3 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.24014 BP_3 29.87 2.20 946 589968018 XP_006996507.1 370 7.7e-33 PREDICTED: zinc finger protein 431-like [Peromyscus maniculatus bairdii] -- -- -- -- -- -- -- -- -- Q9UJN7 344 3.3e-31 Zinc finger protein 391 OS=Homo sapiens GN=ZNF391 PE=2 SV=2 PF02892//PF13912//PF01428//PF00096//PF13465 BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.24016 BP_3 204.72 6.09 1913 189242016 XP_001807518.1 1974 1.6e-218 PREDICTED: carboxypeptidase E-like [Tribolium castaneum] 37787288 AY214171.1 41 1.39038e-09 Paralichthys olivaceus carboxypeptidase H mRNA, complete cds K01294 CPE carboxypeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01294 P37892 1035 4.9e-111 Carboxypeptidase E OS=Lophius americanus GN=cpe PE=2 SV=1 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0004181//GO:0016788//GO:0008270 metallocarboxypeptidase activity//hydrolase activity, acting on ester bonds//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.24017 BP_3 680.73 4.42 7716 817058126 XP_012250513.1 1919 1.5e-211 PREDICTED: beta-1,4-mannosyltransferase egh isoform X1 [Athalia rosae]>gi|817058128|ref|XP_012250514.1| PREDICTED: beta-1,4-mannosyltransferase egh isoform X1 [Athalia rosae] 642920158 XM_970403.3 374 0 PREDICTED: Tribolium castaneum beta-1,4-mannosyltransferase egh (LOC664396), mRNA K02359 EGH egghead protein (zeste-white 4 protein) http://www.genome.jp/dbget-bin/www_bget?ko:K02359 O01346 1850 6.2e-205 Beta-1,4-mannosyltransferase egh OS=Drosophila melanogaster GN=egh PE=2 SV=1 PF00651//PF13506 BTB/POZ domain//Glycosyl transferase family 21 -- -- GO:0016757//GO:0005515 transferase activity, transferring glycosyl groups//protein binding -- -- -- -- Cluster-8309.24021 BP_3 2.26 1.15 384 642920120 XP_008192214.1 323 8.7e-28 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24023 BP_3 52.06 1.17 2444 91082195 XP_971684.1 344 2.0e-29 PREDICTED: nipped-B-like protein B [Tribolium castaneum]>gi|270007443|gb|EFA03891.1| hypothetical protein TcasGA2_TC014015 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T200 132 3.2e-06 Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens GN=ZC3H13 PE=1 SV=1 PF00642//PF08915 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Archaea-specific editing domain of threonyl-tRNA synthetase GO:0006566//GO:0006544//GO:0006435//GO:0006563 threonine metabolic process//glycine metabolic process//threonyl-tRNA aminoacylation//L-serine metabolic process GO:0003676//GO:0008270//GO:0046872//GO:0004829//GO:0005524 nucleic acid binding//zinc ion binding//metal ion binding//threonine-tRNA ligase activity//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.24024 BP_3 592.21 31.71 1192 91077852 XP_971951.1 372 5.7e-33 PREDICTED: uncharacterized protein LOC660645 [Tribolium castaneum]>gi|270002261|gb|EEZ98708.1| hypothetical protein TcasGA2_TC001249 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06910 Male enhanced antigen 1 (MEA1) GO:0007283 spermatogenesis -- -- -- -- -- -- Cluster-8309.24028 BP_3 2318.05 18.79 6237 478257181 ENN77344.1 2459 3.0e-274 hypothetical protein YQE_06170, partial [Dendroctonus ponderosae]>gi|546681413|gb|ERL91510.1| hypothetical protein D910_08840 [Dendroctonus ponderosae] 471419251 XM_004391060.1 39 5.93403e-08 PREDICTED: Trichechus manatus latirostris F-box and WD repeat domain containing 5 (LOC101355169), mRNA K10263 FBXW5 F-box and WD-40 domain protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10263 Q9QXW2 1187 3.8e-128 F-box/WD repeat-containing protein 5 OS=Mus musculus GN=Fbxw5 PE=1 SV=1 PF12937//PF00355//PF00400//PF00646 F-box-like//Rieske [2Fe-2S] domain//WD domain, G-beta repeat//F-box domain GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0051537 oxidoreductase activity//protein binding//2 iron, 2 sulfur cluster binding -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.24029 BP_3 229.59 1.75 6599 478257181 ENN77344.1 1325 9.8e-143 hypothetical protein YQE_06170, partial [Dendroctonus ponderosae]>gi|546681413|gb|ERL91510.1| hypothetical protein D910_08840 [Dendroctonus ponderosae] 471419251 XM_004391060.1 39 6.2805e-08 PREDICTED: Trichechus manatus latirostris F-box and WD repeat domain containing 5 (LOC101355169), mRNA K10263 FBXW5 F-box and WD-40 domain protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10263 Q4KLI9 639 1.4e-64 F-box/WD repeat-containing protein 5 OS=Rattus norvegicus GN=Fbxw5 PE=2 SV=1 PF12937//PF00400//PF01105//PF00646//PF00355 F-box-like//WD domain, G-beta repeat//emp24/gp25L/p24 family/GOLD//F-box domain//Rieske [2Fe-2S] domain GO:0055114//GO:0006810 oxidation-reduction process//transport GO:0051537//GO:0005515//GO:0016491 2 iron, 2 sulfur cluster binding//protein binding//oxidoreductase activity GO:0016021 integral component of membrane KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.2403 BP_3 32.39 2.48 921 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase GO:0009231 riboflavin biosynthetic process GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity -- -- -- -- Cluster-8309.24030 BP_3 86.00 0.85 5186 642928597 XP_008199971.1 3871 0.0e+00 PREDICTED: autophagy-related protein 2 homolog A isoform X3 [Tribolium castaneum] -- -- -- -- -- K17906 ATG2 autophagy-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17906 Q96BY7 992 1.3e-105 Autophagy-related protein 2 homolog B OS=Homo sapiens GN=ATG2B PE=1 SV=5 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG2993 Cytoplasm to vacuole targeting protein Cluster-8309.24031 BP_3 34.43 0.43 4165 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24032 BP_3 71.52 1.67 2360 91087311 XP_975575.1 447 2.3e-41 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K15360 STRA13, CENPX, MHF2 centromere protein X http://www.genome.jp/dbget-bin/www_bget?ko:K15360 P0DJH7 167 2.7e-10 Centromere protein X OS=Gallus gallus GN=STRA13 PE=1 SV=1 PF09415//PF02269 CENP-S associating Centromere protein X//Transcription initiation factor IID, 18kD subunit GO:0006281//GO:0006366//GO:0051382 DNA repair//transcription from RNA polymerase II promoter//kinetochore assembly -- -- -- -- -- -- Cluster-8309.24033 BP_3 71.19 1.21 3138 189237987 XP_001812710.1 3227 0.0e+00 PREDICTED: solute carrier family 12 member 9 [Tribolium castaneum] 632984903 XM_007911190.1 52 1.76228e-15 PREDICTED: Callorhinchus milii solute carrier family 12, member 9 (slc12a9), mRNA K14429 SLC12A9, CCC6 solute carrier family 12 (potassium/chloride transporters), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14429 A2BFP5 1733 9.4e-192 Solute carrier family 12 member 9 OS=Danio rerio GN=slc12a9 PE=3 SV=1 PF00324//PF03522//PF03412 Amino acid permease//Solute carrier family 12//Peptidase C39 family GO:0006811//GO:0006508//GO:0006810//GO:0055085 ion transport//proteolysis//transport//transmembrane transport GO:0008233//GO:0005215//GO:0005524 peptidase activity//transporter activity//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG1288 Amino acid transporters Cluster-8309.24036 BP_3 44.36 2.69 1087 91085455 XP_969485.1 169 1.8e-09 PREDICTED: WASH complex subunit FAM21A [Tribolium castaneum]>gi|270009171|gb|EFA05619.1| hypothetical protein TcasGA2_TC015827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05793 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0006367//GO:0032968 transcription initiation from RNA polymerase II promoter//positive regulation of transcription elongation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.24037 BP_3 839.88 4.00 10419 642932470 XP_008197129.1 572 3.2e-55 PREDICTED: uncharacterized protein YKL105C-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641Q2 235 1.6e-17 WASH complex subunit FAM21A OS=Homo sapiens GN=FAM21A PE=2 SV=3 PF02724//PF09726//PF04889//PF06003//PF05132 CDC45-like protein//Transmembrane protein//Cwf15/Cwc15 cell cycle control protein//Survival motor neuron protein (SMN)//RNA polymerase III RPC4 GO:0000398//GO:0006270//GO:0006206//GO:0006144//GO:0006351//GO:0006383//GO:0006397 mRNA splicing, via spliceosome//DNA replication initiation//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//mRNA processing GO:0003899//GO:0003723//GO:0003677 DNA-directed RNA polymerase activity//RNA binding//DNA binding GO:0005737//GO:0005666//GO:0005730//GO:0016021//GO:0005681//GO:0005634 cytoplasm//DNA-directed RNA polymerase III complex//nucleolus//integral component of membrane//spliceosomal complex//nucleus -- -- Cluster-8309.24039 BP_3 429.00 5.22 4251 91081221 XP_975624.1 731 4.8e-74 PREDICTED: serine/threonine/tyrosine-interacting protein [Tribolium castaneum]>gi|270005257|gb|EFA01705.1| hypothetical protein TcasGA2_TC007281 [Tribolium castaneum] -- -- -- -- -- K18042 STYX serine/threonine/tyrosine-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K18042 Q60969 401 3.6e-37 Serine/threonine/tyrosine-interacting protein OS=Mus musculus GN=Styx PE=1 SV=2 PF00102//PF06596//PF08782//PF09034//PF04179//PF00782 Protein-tyrosine phosphatase//Photosystem II reaction centre X protein (PsbX)//c-SKI Smad4 binding domain//TRADD, N-terminal domain//Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain GO:0007165//GO:0019988//GO:0006570//GO:0016311//GO:0043123//GO:0015979//GO:0006470 signal transduction//charged-tRNA amino acid modification//tyrosine metabolic process//dephosphorylation//positive regulation of I-kappaB kinase/NF-kappaB signaling//photosynthesis//protein dephosphorylation GO:0043399//GO:0005515//GO:0008138//GO:0016791//GO:0004725//GO:0004871//GO:0046332 tRNA A64-2'-O-ribosylphosphate transferase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//phosphatase activity//protein tyrosine phosphatase activity//signal transducer activity//SMAD binding GO:0016020//GO:0009523 membrane//photosystem II KOG1716 Dual specificity phosphatase Cluster-8309.2404 BP_3 3897.27 84.99 2502 270010965 EFA07413.1 1481 3.0e-161 serine protease P84 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 437 1.4e-41 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.24040 BP_3 99.63 8.59 851 642914372 XP_008201652.1 231 9.0e-17 PREDICTED: uncharacterized protein LOC659966 [Tribolium castaneum]>gi|270001589|gb|EEZ98036.1| hypothetical protein TcasGA2_TC000438 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.24041 BP_3 1.00 1.84 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24042 BP_3 600.62 11.16 2886 546678229 ERL88905.1 201 9.2e-13 hypothetical protein D910_06287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11081 Protein of unknown function (DUF2890) GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.24043 BP_3 437.95 5.31 4269 642934852 XP_008197837.1 4830 0.0e+00 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08333 PIK3R4, VPS15 phosphoinositide-3-kinase, regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08333 Q8VD65 1907 8.5e-212 Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus GN=Pik3r4 PE=1 SV=3 PF02985//PF00069//PF00400//PF07714 HEAT repeat//Protein kinase domain//WD domain, G-beta repeat//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG1240 Protein kinase containing WD40 repeats Cluster-8309.24044 BP_3 13.16 0.91 985 478257549 ENN77703.1 470 2.0e-44 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 167 1.1e-10 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.24045 BP_3 38.91 0.79 2669 642921104 XP_008192691.1 1032 3.7e-109 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 A0JNI5 570 5.7e-57 CLK4-associating serine/arginine rich protein OS=Bos taurus GN=CLASRP PE=2 SV=1 PF04882//PF02535//PF09726//PF05279//PF15678 Peroxin-3//ZIP Zinc transporter//Transmembrane protein//Aspartyl beta-hydroxylase N-terminal region//Centriole duplication and mitotic chromosome congression GO:0030001//GO:0007031//GO:0055085//GO:0090307 metal ion transport//peroxisome organization//transmembrane transport//mitotic spindle assembly GO:0046873 metal ion transmembrane transporter activity GO:0016021//GO:0016020//GO:0005779 integral component of membrane//membrane//integral component of peroxisomal membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.24046 BP_3 33.74 1.28 1566 332372618 AEE61451.1 464 1.6e-43 unknown [Dendroctonus ponderosae]>gi|478254395|gb|ENN74647.1| hypothetical protein YQE_08765, partial [Dendroctonus ponderosae]>gi|546682357|gb|ERL92305.1| hypothetical protein D910_09622 [Dendroctonus ponderosae] -- -- -- -- -- K15433 CGI99, CLE7, RLLM1 RLL motif containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15433 Q9CQE8 269 2.7e-22 UPF0568 protein C14orf166 homolog OS=Mus musculus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24047 BP_3 6.64 0.46 988 761906601 XP_011402965.1 212 1.7e-14 PREDICTED: ankyrin repeat domain-containing protein 17-like [Amphimedon queenslandica] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5UPG5 191 1.9e-13 Putative ankyrin repeat protein L93 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L93 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24048 BP_3 36.14 1.08 1909 270010553 EFA07001.1 1061 1.2e-112 hypothetical protein TcasGA2_TC009970 [Tribolium castaneum] -- -- -- -- -- K14942 KHDRBS3, SLM2 KH domain-containing, RNA-binding, signal transduction-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14942 Q5VWX1 417 2.3e-39 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Homo sapiens GN=KHDRBS2 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.2405 BP_3 19.00 0.35 2930 795016292 XP_011858446.1 412 3.2e-37 PREDICTED: uncharacterized protein LOC105556000 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00444 Ribosomal protein L36 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.24051 BP_3 855.97 10.83 4102 91081353 XP_971021.1 1303 2.2e-140 PREDICTED: protein FAM114A2 [Tribolium castaneum]>gi|270005192|gb|EFA01640.1| hypothetical protein TcasGA2_TC007210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDV3 568 1.5e-56 Probable nucleoporin Nup58 OS=Drosophila melanogaster GN=Nup58 PE=2 SV=1 PF08515//PF14620//PF00435//PF04029 Transforming growth factor beta type I GS-motif//YpeB sporulation//Spectrin repeat//2-phosphosulpholactate phosphatase GO:0009847//GO:0006468//GO:0009069//GO:0016310//GO:0007178 spore germination//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0050532//GO:0000287//GO:0004675//GO:0005515//GO:0005524 2-phosphosulfolactate phosphatase activity//magnesium ion binding//transmembrane receptor protein serine/threonine kinase activity//protein binding//ATP binding GO:0016020 membrane -- -- Cluster-8309.24052 BP_3 7.00 0.92 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24055 BP_3 23.95 0.52 2494 637366323 XP_008121191.1 644 3.4e-64 PREDICTED: oocyte zinc finger protein XlCOF6-like, partial [Anolis carolinensis] 195570403 XM_002103161.1 85 6.32019e-34 Drosophila simulans GD19093 (Dsim\GD19093), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 590 2.6e-59 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF00096//PF13465//PF11615//PF07776//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Protein of unknown function (DUF3249)//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger GO:0000266 mitochondrial fission GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634//GO:0005739 nucleus//mitochondrion -- -- Cluster-8309.24058 BP_3 390.86 4.26 4709 642923667 XP_008193834.1 3845 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2245 6.0e-251 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF03193//PF00005//PF06414//PF00437//PF00735//PF01926//PF13304//PF00664 Protein of unknown function, DUF258//ABC transporter//Zeta toxin//Type II/IV secretion system protein//Septin//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0016301//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24059 BP_3 1481.58 16.40 4646 642923667 XP_008193834.1 3736 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91660 2275 2.0e-254 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF06414//PF00005//PF03193//PF00664//PF13304//PF01926//PF00735//PF00437 Zeta toxin//ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Septin//Type II/IV secretion system protein GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887//GO:0016301 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24061 BP_3 60.61 0.57 5375 642912265 XP_008200629.1 1187 8.0e-127 PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912267|ref|XP_008200630.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912269|ref|XP_008200631.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q6IRB8 281 3.7e-23 Lysine-specific demethylase 3A-A OS=Xenopus laevis GN=kdm3a-a PE=2 SV=1 PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.24062 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24063 BP_3 268.00 9.97 1587 91079302 XP_966978.1 1460 5.2e-159 PREDICTED: serine/threonine-protein kinase RIO2 [Tribolium castaneum]>gi|270004321|gb|EFA00769.1| hypothetical protein TcasGA2_TC003655 [Tribolium castaneum] -- -- -- -- -- K07179 RIOK2 RIO kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07179 Q9CQS5 1100 1.2e-118 Serine/threonine-protein kinase RIO2 OS=Mus musculus GN=Riok2 PE=2 SV=1 PF09202//PF06293 Rio2, N-terminal//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0005524//GO:0004674 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein serine/threonine kinase activity GO:0016020 membrane KOG2268 Serine/threonine protein kinase Cluster-8309.24064 BP_3 520.37 8.35 3297 546676098 ERL87165.1 3546 0.0e+00 hypothetical protein D910_04565 [Dendroctonus ponderosae] -- -- -- -- -- K08675 PRSS15, PIM1 Lon-like ATP-dependent protease http://www.genome.jp/dbget-bin/www_bget?ko:K08675 P36776 2821 0.0e+00 Lon protease homolog, mitochondrial OS=Homo sapiens GN=LONP1 PE=1 SV=2 PF02367//PF03266//PF07726//PF03193//PF00005//PF02190//PF00931//PF00910//PF05496//PF07728//PF01695//PF07724//PF06309//PF05362//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//NTPase//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//ATP-dependent protease La (LON) substrate-binding domain//NB-ARC domain//RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//Torsin//Lon protease (S16) C-terminal proteolytic domain//ATPase family associated with various cellular activities (AAA) GO:0006510//GO:0006281//GO:0002949//GO:0006310//GO:0006508 obsolete ATP-dependent proteolysis//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis GO:0004252//GO:0004176//GO:0016887//GO:0003924//GO:0005524//GO:0098519//GO:0009378//GO:0003724//GO:0005525//GO:0043531//GO:0003723 serine-type endopeptidase activity//ATP-dependent peptidase activity//ATPase activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//four-way junction helicase activity//RNA helicase activity//GTP binding//ADP binding//RNA binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG2004 Mitochondrial ATP-dependent protease PIM1/LON Cluster-8309.24065 BP_3 406.15 6.62 3247 91077206 XP_973021.1 3441 0.0e+00 PREDICTED: lon protease homolog, mitochondrial isoform X2 [Tribolium castaneum]>gi|270001698|gb|EEZ98145.1| hypothetical protein TcasGA2_TC000570 [Tribolium castaneum] -- -- -- -- -- K08675 PRSS15, PIM1 Lon-like ATP-dependent protease http://www.genome.jp/dbget-bin/www_bget?ko:K08675 Q924S5 2806 0.0e+00 Lon protease homolog, mitochondrial OS=Rattus norvegicus GN=Lonp1 PE=2 SV=1 PF00005//PF07726//PF03266//PF03193//PF00910//PF02190//PF01443//PF05496//PF07724//PF02367//PF00931//PF01695//PF07728//PF06309//PF00004//PF05362 ABC transporter//ATPase family associated with various cellular activities (AAA)//NTPase//Protein of unknown function, DUF258//RNA helicase//ATP-dependent protease La (LON) substrate-binding domain//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (Cdc48 subfamily)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Torsin//ATPase family associated with various cellular activities (AAA)//Lon protease (S16) C-terminal proteolytic domain GO:0002949//GO:0006310//GO:0006508//GO:0006281//GO:0006510 tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis//DNA repair//obsolete ATP-dependent proteolysis GO:0043531//GO:0003723//GO:0009378//GO:0003724//GO:0005525//GO:0003924//GO:0005524//GO:0098519//GO:0004252//GO:0004176//GO:0016887 ADP binding//RNA binding//four-way junction helicase activity//RNA helicase activity//GTP binding//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//serine-type endopeptidase activity//ATP-dependent peptidase activity//ATPase activity GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG2004 Mitochondrial ATP-dependent protease PIM1/LON Cluster-8309.24066 BP_3 139.42 2.16 3410 91077206 XP_973021.1 1962 6.9e-217 PREDICTED: lon protease homolog, mitochondrial isoform X2 [Tribolium castaneum]>gi|270001698|gb|EEZ98145.1| hypothetical protein TcasGA2_TC000570 [Tribolium castaneum] -- -- -- -- -- K08675 PRSS15, PIM1 Lon-like ATP-dependent protease http://www.genome.jp/dbget-bin/www_bget?ko:K08675 Q924S5 1563 5.2e-172 Lon protease homolog, mitochondrial OS=Rattus norvegicus GN=Lonp1 PE=2 SV=1 PF02190//PF00910//PF04851//PF03266//PF07726//PF03193//PF00005//PF07724//PF05496//PF00931//PF02367//PF06309//PF05362//PF00004//PF07728//PF01695 ATP-dependent protease La (LON) substrate-binding domain//RNA helicase//Type III restriction enzyme, res subunit//NTPase//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//AAA domain (Cdc48 subfamily)//Holliday junction DNA helicase ruvB N-terminus//NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Torsin//Lon protease (S16) C-terminal proteolytic domain//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006508//GO:0006310//GO:0002949//GO:0006510//GO:0006281 proteolysis//DNA recombination//tRNA threonylcarbamoyladenosine modification//obsolete ATP-dependent proteolysis//DNA repair GO:0003724//GO:0009378//GO:0005525//GO:0043531//GO:0003677//GO:0003723//GO:0004252//GO:0016887//GO:0004176//GO:0003924//GO:0016787//GO:0098519//GO:0005524 RNA helicase activity//four-way junction helicase activity//GTP binding//ADP binding//DNA binding//RNA binding//serine-type endopeptidase activity//ATPase activity//ATP-dependent peptidase activity//GTPase activity//hydrolase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG2004 Mitochondrial ATP-dependent protease PIM1/LON Cluster-8309.24067 BP_3 187.17 7.32 1524 91079782 XP_967732.1 1443 4.7e-157 PREDICTED: 39S ribosomal protein L38, mitochondrial [Tribolium castaneum]>gi|270003311|gb|EEZ99758.1| hypothetical protein TcasGA2_TC002530 [Tribolium castaneum] 170048742 XM_001870724.1 54 6.54141e-17 Culex quinquefasciatus mitochondrial ribosomal protein L38, mRNA K17419 MRPL38 large subunit ribosomal protein L38 http://www.genome.jp/dbget-bin/www_bget?ko:K17419 Q3ZBF3 787 2.2e-82 39S ribosomal protein L38, mitochondrial OS=Bos taurus GN=MRPL38 PE=1 SV=2 PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.24068 BP_3 339.00 7.67 2423 91086035 XP_973305.1 1682 1.4e-184 PREDICTED: centromere/kinetochore protein zw10 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RFM4 796 3.2e-83 Centromere/kinetochore protein zw10 homolog OS=Pongo abelii GN=ZW10 PE=2 SV=3 PF05130//PF06248//PF00439 FlgN protein//Centromere/kinetochore Zw10//Bromodomain GO:0044780//GO:0007067 bacterial-type flagellum assembly//mitotic nuclear division GO:0005515 protein binding GO:0005634//GO:0000775 nucleus//chromosome, centromeric region KOG2163 Centromere/kinetochore protein zw10 involved in mitotic chromosome segregation Cluster-8309.24070 BP_3 167.29 3.23 2788 270003257 EEZ99704.1 685 6.7e-69 hypothetical protein TcasGA2_TC002465 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q60HE9 463 1.5e-44 Lysosomal alpha-mannosidase OS=Macaca fascicularis GN=MAN2B1 PE=2 SV=1 PF07748 Glycosyl hydrolases family 38 C-terminal domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923 mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.24075 BP_3 26595.50 167.95 7924 478259801 ENN79629.1 3189 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.13598e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.6e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF00443//PF01433 Ubiquitin carboxyl-terminal hydrolase//Peptidase family M1 GO:0016579 protein deubiquitination GO:0008237//GO:0008270//GO:0036459 metallopeptidase activity//zinc ion binding//ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.24077 BP_3 49.03 0.45 5529 688607278 XP_009294113.1 264 8.8e-20 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 721 [Danio rerio] 642937236 XM_008200529.1 145 6.24926e-67 PREDICTED: Tribolium castaneum zinc finger protein 1 (LOC100141776), transcript variant X4, mRNA K09299 ZEB1_2 zinc finger homeobox protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K09299 Q03936 256 3.1e-20 Zinc finger protein 92 OS=Homo sapiens GN=ZNF92 PE=2 SV=2 PF13912//PF05920//PF00096//PF13465//PF00046//PF01155 C2H2-type zinc finger//Homeobox KN domain//Zinc finger, C2H2 type//Zinc-finger double domain//Homeobox domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006355 cellular protein modification process//regulation of transcription, DNA-templated GO:0016151//GO:0046872//GO:0003677 nickel cation binding//metal ion binding//DNA binding -- -- -- -- Cluster-8309.2408 BP_3 1.37 0.51 421 751232347 XP_011169784.1 305 1.2e-25 PREDICTED: uncharacterized protein LOC105202802 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24084 BP_3 5.00 0.37 946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24087 BP_3 138.96 10.01 961 478255204 ENN75433.1 945 1.6e-99 hypothetical protein YQE_07984, partial [Dendroctonus ponderosae] -- -- -- -- -- K15447 TRM44, METTL19 tRNASer (uridine44-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15447 Q9VHB9 569 2.7e-57 Probable tRNA (uracil-O(2)-)-methyltransferase OS=Drosophila melanogaster GN=trmt44 PE=2 SV=2 PF01544//PF07757 CorA-like Mg2+ transporter protein//Predicted AdoMet-dependent methyltransferase GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873//GO:0008168 metal ion transmembrane transporter activity//methyltransferase activity GO:0016020 membrane KOG3790 Uncharacterized conserved protein Cluster-8309.24088 BP_3 112.89 6.19 1171 189241264 XP_974292.2 754 2.8e-77 PREDICTED: probable tRNA (uracil-O(2)-)-methyltransferase [Tribolium castaneum]>gi|642936064|ref|XP_008198287.1| PREDICTED: probable tRNA (uracil-O(2)-)-methyltransferase [Tribolium castaneum]>gi|270013210|gb|EFA09658.1| hypothetical protein TcasGA2_TC011784 [Tribolium castaneum] -- -- -- -- -- K15447 TRM44, METTL19 tRNASer (uridine44-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15447 Q4KLT3 243 2.1e-19 Probable tRNA (uracil-O(2)-)-methyltransferase OS=Xenopus laevis GN=trmt44 PE=2 SV=1 PF07757 Predicted AdoMet-dependent methyltransferase -- -- GO:0008168 methyltransferase activity -- -- KOG3790 Uncharacterized conserved protein Cluster-8309.24090 BP_3 20.11 1.04 1226 546684530 ERL94161.1 778 4.9e-80 hypothetical protein D910_11443, partial [Dendroctonus ponderosae] -- -- -- -- -- K15447 TRM44, METTL19 tRNASer (uridine44-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15447 Q4KLT3 243 2.2e-19 Probable tRNA (uracil-O(2)-)-methyltransferase OS=Xenopus laevis GN=trmt44 PE=2 SV=1 PF04464//PF07757 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase//Predicted AdoMet-dependent methyltransferase -- -- GO:0047355//GO:0008168 CDP-glycerol glycerophosphotransferase activity//methyltransferase activity GO:0016020 membrane KOG3790 Uncharacterized conserved protein Cluster-8309.24095 BP_3 30.68 0.34 4638 642927783 XP_008195404.1 4526 0.0e+00 PREDICTED: eukaryotic translation initiation factor 2-alpha kinase 4 [Tribolium castaneum]>gi|270009882|gb|EFA06330.1| hypothetical protein TcasGA2_TC009201 [Tribolium castaneum] -- -- -- -- -- K16196 EIF2AK4 eukaryotic translation initiation factor 2-alpha kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16196 Q9P2K8 2158 7.2e-241 Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 PF07714//PF05773//PF00069 Protein tyrosine kinase//RWD domain//Protein kinase domain GO:0044267//GO:0016310//GO:0009069//GO:0006468 cellular protein metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0000166//GO:0004672//GO:0004674//GO:0005524//GO:0005515 nucleotide binding//protein kinase activity//protein serine/threonine kinase activity//ATP binding//protein binding -- -- KOG1035 eIF-2alpha kinase GCN2 Cluster-8309.24096 BP_3 496.00 22.38 1360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11057 Cortexin of kidney -- -- -- -- GO:0031224 intrinsic component of membrane -- -- Cluster-8309.24098 BP_3 35.00 0.55 3336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.241 BP_3 27.76 1.11 1492 821475571 XP_012401294.1 640 5.9e-64 PREDICTED: zinc finger protein 260-like [Sarcophilus harrisii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96NI8 602 6.2e-61 Zinc finger protein 570 OS=Homo sapiens GN=ZNF570 PE=2 SV=1 PF07776//PF02325//PF13912//PF02892//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//YGGT family//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.2410 BP_3 8.00 0.34 1430 270015520 EFA11968.1 335 1.3e-28 hypothetical protein TcasGA2_TC004049 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05870//PF08219//PF01355//PF00665//PF05038 Phenolic acid decarboxylase (PAD)//Outer membrane protein TOM13//High potential iron-sulfur protein//Integrase core domain//Cytochrome Cytochrome b558 alpha-subunit GO:0006118//GO:0019646//GO:0015074 obsolete electron transport//aerobic electron transport chain//DNA integration GO:0009055//GO:0016831//GO:0020037 electron carrier activity//carboxy-lyase activity//heme binding GO:0005741 mitochondrial outer membrane -- -- Cluster-8309.24101 BP_3 38.97 0.53 3845 189240717 XP_974290.2 881 1.7e-91 PREDICTED: polycomb group protein Pc isoform X3 [Tribolium castaneum]>gi|270014283|gb|EFA10731.1| polycomb [Tribolium castaneum] -- -- -- -- -- K11454 CBX7 chromobox protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11454 P26017 232 1.3e-17 Polycomb group protein Pc OS=Drosophila melanogaster GN=Pc PE=1 SV=1 PF00437 Type II/IV secretion system protein GO:0006810 transport GO:0005524 ATP binding -- -- KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.24104 BP_3 1397.25 16.79 4302 91093869 XP_967782.1 6308 0.0e+00 PREDICTED: cytoplasmic FMR1-interacting protein [Tribolium castaneum]>gi|270014526|gb|EFA10974.1| hypothetical protein TcasGA2_TC004140 [Tribolium castaneum] 572271770 XM_006613756.1 1177 0 PREDICTED: Apis dorsata cytoplasmic FMR1-interacting protein-like (LOC102675501), mRNA K05749 CYFIP cytoplasmic FMR1 interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05749 Q9VF87 5574 0.0e+00 Cytoplasmic FMR1-interacting protein OS=Drosophila melanogaster GN=Sra-1 PE=1 SV=1 -- -- -- -- -- -- GO:0005737 cytoplasm KOG3534 p53 inducible protein PIR121 Cluster-8309.24105 BP_3 663.79 7.90 4344 642936074 XP_008198292.1 3618 0.0e+00 PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum]>gi|642936076|ref|XP_008198293.1| PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum] 617356403 XM_007554354.1 36 1.91894e-06 PREDICTED: Poecilia formosa SMG6 nonsense mediated mRNA decay factor (smg6), transcript variant X2, mRNA K11124 SMG6, EST1A protein SMG6 http://www.genome.jp/dbget-bin/www_bget?ko:K11124 Q5RAK6 1366 4.7e-149 Telomerase-binding protein EST1A OS=Pongo abelii GN=SMG6 PE=2 SV=1 PF01805//PF00282 Surp module//Pyridoxal-dependent decarboxylase conserved domain GO:0019752//GO:0006396 carboxylic acid metabolic process//RNA processing GO:0030170//GO:0016831//GO:0003723 pyridoxal phosphate binding//carboxy-lyase activity//RNA binding -- -- KOG2162 Nonsense-mediated mRNA decay protein Cluster-8309.2411 BP_3 219.00 17.61 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24111 BP_3 292.00 10.54 1627 642920461 XP_008192360.1 249 1.4e-18 PREDICTED: CREB-binding protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24112 BP_3 13.04 0.51 1525 91084541 XP_972999.1 786 7.1e-81 PREDICTED: vacuolar protein sorting-associated protein 26B-like [Tribolium castaneum]>gi|270008666|gb|EFA05114.1| hypothetical protein TcasGA2_TC015215 [Tribolium castaneum] 754341915 XM_004365015.2 73 1.79441e-27 Capsaspora owczarzaki ATCC 30864 vacuolar protein sorting-associated protein 26B-B mRNA K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q5R436 559 6.2e-56 Vacuolar protein sorting-associated protein 26B OS=Pongo abelii GN=VPS26B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.24113 BP_3 18.80 0.37 2759 642924772 XP_008194434.1 1124 8.3e-120 PREDICTED: netrin receptor UNC5C isoform X2 [Tribolium castaneum] -- -- -- -- -- K07521 UNC5 netrin receptor unc-5 http://www.genome.jp/dbget-bin/www_bget?ko:K07521 Q95TU8 633 2.9e-64 Netrin receptor unc-5 OS=Drosophila melanogaster GN=unc-5 PE=1 SV=1 PF11468//PF13895//PF01632 Aromatic prenyltransferase Orf2//Immunoglobulin domain//Ribosomal protein L35 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0016740//GO:0003735//GO:0005515 transferase activity//structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG1480 Netrin transmembrane receptor unc-5 Cluster-8309.24114 BP_3 8.00 1.65 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24115 BP_3 25.22 0.44 3082 478253163 ENN73534.1 190 1.9e-11 hypothetical protein YQE_09785, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.24116 BP_3 32.62 0.52 3344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24122 BP_3 247.03 1.52 8121 478251011 ENN71492.1 1218 3.1e-130 hypothetical protein YQE_11788, partial [Dendroctonus ponderosae] -- -- -- -- -- K09592 EGLN, HPH hypoxia-inducible factor prolyl hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K09592 Q91YE3 670 4.4e-68 Egl nine homolog 1 OS=Mus musculus GN=Egln1 PE=2 SV=2 PF01254//PF13640//PF03117 Nuclear transition protein 2//2OG-Fe(II) oxygenase superfamily//UL49 family GO:0016032//GO:0007283//GO:0055114 viral process//spermatogenesis//oxidation-reduction process GO:0003677//GO:0016491 DNA binding//oxidoreductase activity GO:0000786//GO:0005634//GO:0019033 nucleosome//nucleus//viral tegument KOG3710 EGL-Nine (EGLN) protein Cluster-8309.24126 BP_3 536.77 3.60 7473 546683888 ERL93636.1 918 1.7e-95 hypothetical protein D910_10924 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NZM4 177 6.0e-11 Glioma tumor suppressor candidate region gene 1 protein OS=Homo sapiens GN=GLTSCR1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24128 BP_3 548.87 22.08 1490 91077766 XP_968426.1 1334 2.0e-144 PREDICTED: WD repeat domain phosphoinositide-interacting protein 4 [Tribolium castaneum]>gi|270002238|gb|EEZ98685.1| hypothetical protein TcasGA2_TC001220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCV0 1088 2.7e-117 WD repeat domain phosphoinositide-interacting protein 4 OS=Xenopus laevis GN=wdr45 PE=2 SV=1 PF00400//PF03178 WD domain, G-beta repeat//CPSF A subunit region -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0005634 nucleus KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.24129 BP_3 7.00 0.33 1322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2413 BP_3 1.00 1.06 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24130 BP_3 15.05 1.53 767 91089745 XP_975162.1 391 2.3e-35 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 Q1RMT7 308 3.9e-27 Serine/threonine-protein kinase RIO3 OS=Bos taurus GN=RIOK3 PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.24131 BP_3 73.94 1.76 2312 100811805 BAE94685.1 2536 1.3e-283 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 754 2.3e-78 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.24134 BP_3 183.38 7.03 1549 668447779 KFB37519.1 608 3.2e-60 AGAP011148-PA-like protein [Anopheles sinensis] 645021074 XM_008209220.1 57 1.42959e-18 PREDICTED: Nasonia vitripennis 39S ribosomal protein L14, mitochondrial (LOC100115115), transcript variant X3, mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 O08709 435 1.5e-41 Peroxiredoxin-6 OS=Mus musculus GN=Prdx6 PE=1 SV=3 PF00238//PF08534//PF00578 Ribosomal protein L14p/L23e//Redoxin//AhpC/TSA family GO:0006412//GO:0042254//GO:0055114 translation//ribosome biogenesis//oxidation-reduction process GO:0016209//GO:0003735//GO:0016491 antioxidant activity//structural constituent of ribosome//oxidoreductase activity GO:0005840 ribosome KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.24137 BP_3 6.91 0.31 1379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24138 BP_3 14.24 0.52 1624 123482337 XP_001323756.1 242 9.1e-18 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121906627|gb|EAY11533.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q9EP71 189 5.3e-13 Ankycorbin OS=Mus musculus GN=Rai14 PE=1 SV=1 PF13606//PF00340//PF00023 Ankyrin repeat//Interleukin-1 / 18//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005615 extracellular space KOG4177 Ankyrin Cluster-8309.24144 BP_3 11.00 0.40 1625 241780604 XP_002400201.1 633 4.2e-63 E3 ubiquitin ligase, putative [Ixodes scapularis]>gi|215510686|gb|EEC20139.1| E3 ubiquitin ligase, putative [Ixodes scapularis] -- -- -- -- -- K09250 CNBP cellular nucleic acid-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09250 Q04832 426 1.7e-40 DNA-binding protein HEXBP OS=Leishmania major GN=HEXBP PE=3 SV=1 PF04565//PF00098 RNA polymerase Rpb2, domain 3//Zinc knuckle GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0008270//GO:0043169//GO:0003676//GO:0003899//GO:0003824//GO:0003677 zinc ion binding//cation binding//nucleic acid binding//DNA-directed RNA polymerase activity//catalytic activity//DNA binding GO:0005730 nucleolus KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.24146 BP_3 421.41 5.94 3709 478250611 ENN71103.1 1166 1.5e-124 hypothetical protein YQE_12036, partial [Dendroctonus ponderosae]>gi|546673105|gb|ERL84774.1| hypothetical protein D910_02199 [Dendroctonus ponderosae] -- -- -- -- -- K12195 CHMP6, VPS20 charged multivesicular body protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12195 O18391 805 4.5e-84 Probable serine hydrolase OS=Drosophila melanogaster GN=kraken PE=2 SV=1 PF01674//PF00975//PF01764//PF01063//PF03357//PF07819 Lipase (class 2)//Thioesterase domain//Lipase (class 3)//Amino-transferase class IV//Snf7//PGAP1-like protein GO:0006505//GO:0008152//GO:0006629//GO:0006886//GO:0007034//GO:0009058 GPI anchor metabolic process//metabolic process//lipid metabolic process//intracellular protein transport//vacuolar transport//biosynthetic process GO:0003824//GO:0016788//GO:0016787 catalytic activity//hydrolase activity, acting on ester bonds//hydrolase activity -- -- -- -- Cluster-8309.24150 BP_3 148.18 0.55 13273 642930187 XP_008196292.1 2642 3.8e-295 PREDICTED: spatacsin [Tribolium castaneum]>gi|270009457|gb|EFA05905.1| hypothetical protein TcasGA2_TC008718 [Tribolium castaneum] 195121589 XM_002005267.1 94 3.37585e-38 Drosophila mojavensis GI20407 (Dmoj\GI20407), mRNA K07832 RIT1 Ras-like without CAAX 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07832 P70426 634 1.1e-63 GTP-binding protein Rit1 OS=Mus musculus GN=Rit1 PE=1 SV=1 PF08533//PF00025//PF03015//PF01979//PF08477//PF00071//PF03193//PF00962//PF02459 Beta-galactosidase C-terminal domain//ADP-ribosylation factor family//Male sterility protein//Amidohydrolase family//Ras of Complex, Roc, domain of DAPkinase//Ras family//Protein of unknown function, DUF258//Adenosine/AMP deaminase//Adenoviral DNA terminal protein GO:0006260//GO:0046486//GO:0006687//GO:0007264//GO:0006012//GO:0006027 DNA replication//glycerolipid metabolic process//glycosphingolipid metabolic process//small GTPase mediated signal transduction//galactose metabolic process//glycosaminoglycan catabolic process GO:0080019//GO:0005525//GO:0016787//GO:0004565//GO:0003677//GO:0003924//GO:0019239 fatty-acyl-CoA reductase (alcohol-forming) activity//GTP binding//hydrolase activity//beta-galactosidase activity//DNA binding//GTPase activity//deaminase activity GO:0009341 beta-galactosidase complex KOG0395 Ras-related GTPase Cluster-8309.24153 BP_3 747.33 7.69 4977 91082041 XP_970854.1 1810 4.2e-199 PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|642921977|ref|XP_008192967.1| PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|270007300|gb|EFA03748.1| hypothetical protein TcasGA2_TC013857 [Tribolium castaneum] -- -- -- -- -- K10519 ZBTB48, HKR3 zinc finger and BTB domain-containing protein 48 http://www.genome.jp/dbget-bin/www_bget?ko:K10519 Q5R4K8 177 4.0e-11 Zinc finger protein 615 OS=Pongo abelii GN=ZNF615 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.24154 BP_3 28.58 0.44 3449 642915391 XP_008190597.1 403 4.2e-36 PREDICTED: cytochrome c oxidase subunit 6B2 isoform X1 [Tribolium castaneum] 642915392 XM_969527.2 84 3.15405e-33 PREDICTED: Tribolium castaneum cytochrome c oxidase subunit 6B2 (LOC663486), transcript variant X2, mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 P14854 264 2.2e-21 Cytochrome c oxidase subunit 6B1 OS=Homo sapiens GN=COX6B1 PE=1 SV=2 PF02297//PF07393 Cytochrome oxidase c subunit VIb//Exocyst complex component Sec10 GO:0006123//GO:0006887//GO:0048278//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//exocytosis//vesicle docking//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005737//GO:0005739 respiratory chain complex IV//cytoplasm//mitochondrion KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.24157 BP_3 440.00 18.01 1469 642934522 XP_001812598.2 826 1.6e-85 PREDICTED: O-acetyl-ADP-ribose deacetylase MACROD2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PAV8 609 9.5e-62 O-acetyl-ADP-ribose deacetylase MACROD2 OS=Xenopus laevis GN=macrod2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.24159 BP_3 35.98 0.56 3409 91082257 XP_973105.1 1260 1.7e-135 PREDICTED: signal transducing adapter molecule 2 [Tribolium castaneum]>gi|270007457|gb|EFA03905.1| hypothetical protein TcasGA2_TC014037 [Tribolium castaneum] -- -- -- -- -- K04705 STAM signal transducing adaptor molecule http://www.genome.jp/dbget-bin/www_bget?ko:K04705 Q92783 737 3.2e-76 Signal transducing adapter molecule 1 OS=Homo sapiens GN=STAM PE=1 SV=3 PF00790//PF14604//PF00018 VHS domain//Variant SH3 domain//SH3 domain GO:0006886 intracellular protein transport GO:0005515 protein binding GO:0005622 intracellular KOG2199 Signal transducing adaptor protein STAM/STAM2 Cluster-8309.24160 BP_3 305.00 7.45 2265 91092880 XP_970276.1 1691 1.2e-185 PREDICTED: glucose-fructose oxidoreductase domain-containing protein 2 [Tribolium castaneum]>gi|270003088|gb|EEZ99535.1| hypothetical protein TcasGA2_TC000117 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3B7J2 877 1.2e-92 Glucose-fructose oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=GFOD2 PE=2 SV=1 PF03447//PF01408 Homoserine dehydrogenase, NAD binding domain//Oxidoreductase family, NAD-binding Rossmann fold GO:0055114 oxidation-reduction process GO:0016491//GO:0000166//GO:0050661 oxidoreductase activity//nucleotide binding//NADP binding -- -- KOG2742 Predicted oxidoreductase Cluster-8309.24162 BP_3 187.83 2.30 4230 478255350 ENN75576.1 1484 2.3e-161 hypothetical protein YQE_07919, partial [Dendroctonus ponderosae] -- -- -- -- -- K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q9VSD7 1226 7.8e-133 Lariat debranching enzyme OS=Drosophila melanogaster GN=ldbr PE=1 SV=1 PF00149//PF05011//PF01507 Calcineurin-like phosphoesterase//Lariat debranching enzyme, C-terminal domain//Phosphoadenosine phosphosulfate reductase family GO:0006397//GO:0008152 mRNA processing//metabolic process GO:0016787//GO:0016788//GO:0003824 hydrolase activity//hydrolase activity, acting on ester bonds//catalytic activity -- -- KOG2863 RNA lariat debranching enzyme Cluster-8309.24165 BP_3 113.22 8.50 934 642936409 XP_008198421.1 466 5.6e-44 PREDICTED: APOPT family protein CG14806, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q148E1 284 2.9e-24 Apoptogenic protein 1, mitochondrial OS=Bos taurus GN=APOPT1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4094 Uncharacterized conserved protein Cluster-8309.24167 BP_3 62.55 1.89 1886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24168 BP_3 2.00 2.16 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24171 BP_3 9.00 0.74 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13762 Mitochondrial splicing apparatus component GO:0000372 Group I intron splicing -- -- GO:0030529 intracellular ribonucleoprotein complex -- -- Cluster-8309.24177 BP_3 9.42 0.92 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24181 BP_3 10.00 1.57 599 642924189 XP_008194189.1 165 2.9e-09 PREDICTED: intracellular protein transport protein uso1 [Tribolium castaneum]>gi|270007853|gb|EFA04301.1| hypothetical protein TcasGA2_TC014593 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15898//PF10147//PF04111//PF07989 cGMP-dependent protein kinase interacting domain//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//Autophagy protein Apg6//Centrosomin N-terminal motif 1 GO:0007049//GO:0006914 cell cycle//autophagy GO:0019901 protein kinase binding GO:0005815//GO:0005634 microtubule organizing center//nucleus -- -- Cluster-8309.24182 BP_3 130.44 8.36 1044 91085093 XP_967751.1 626 1.7e-62 PREDICTED: uridine diphosphate glucose pyrophosphatase [Tribolium castaneum]>gi|270008500|gb|EFA04948.1| hypothetical protein TcasGA2_TC015015 [Tribolium castaneum] -- -- -- -- -- K08077 NUDT14 UDP-sugar diphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K08077 Q05B60 266 4.0e-22 Uridine diphosphate glucose pyrophosphatase OS=Bos taurus GN=NUDT14 PE=2 SV=1 PF09008//PF00293 Head binding//NUDIX domain GO:0009405 pathogenesis GO:0016787 hydrolase activity -- -- KOG4432 Uncharacterized NUDIX family hydrolase Cluster-8309.24183 BP_3 441.43 1.91 11454 642933099 XP_973043.3 3576 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.4e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF08587//PF14572//PF00076 Phosphoribosyl transferase domain//Ubiquitin associated domain (UBA)//Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006098//GO:0009069//GO:0006144//GO:0009165//GO:0016310//GO:0009116 pentose-phosphate shunt//serine family amino acid metabolic process//purine nucleobase metabolic process//nucleotide biosynthetic process//phosphorylation//nucleoside metabolic process GO:0003676//GO:0004749//GO:0000287//GO:0004674 nucleic acid binding//ribose phosphate diphosphokinase activity//magnesium ion binding//protein serine/threonine kinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.24185 BP_3 99.78 7.63 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24187 BP_3 18.00 2.04 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24190 BP_3 31.01 0.58 2888 270007985 EFA04433.1 812 1.3e-83 hypothetical protein TcasGA2_TC014734 [Tribolium castaneum] 572257831 XM_006607250.1 36 1.27038e-06 PREDICTED: Apis dorsata tyrosine-protein kinase PR2-like (LOC102681833), mRNA -- -- -- -- Q9I7F7 133 2.9e-06 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF01529//PF06423 DHHC palmitoyltransferase//GWT1 GO:0006506 GPI anchor biosynthetic process GO:0008270//GO:0016746 zinc ion binding//transferase activity, transferring acyl groups GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.24191 BP_3 356.00 4.74 3913 478257482 ENN77638.1 992 2.4e-104 hypothetical protein YQE_05932, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q29116 187 2.2e-12 Tenascin OS=Sus scrofa GN=TNC PE=1 SV=1 PF00731 AIR carboxylase GO:0006189 'de novo' IMP biosynthetic process -- -- -- -- -- -- Cluster-8309.24192 BP_3 330.14 13.38 1481 642911532 XP_008199462.1 1573 3.8e-172 PREDICTED: protein eva-1 homolog C isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58659 355 2.7e-32 Protein eva-1 homolog C OS=Mus musculus GN=Eva1c PE=2 SV=2 PF02140 Galactose binding lectin domain -- -- GO:0030246 carbohydrate binding -- -- KOG4729 Galactoside-binding lectin Cluster-8309.24193 BP_3 10.44 0.38 1630 189233947 XP_974111.2 221 2.5e-15 PREDICTED: uncharacterized protein LOC662950 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24194 BP_3 770.14 11.08 3643 189234810 XP_969391.2 1486 1.2e-161 PREDICTED: monocarboxylate transporter 10 [Tribolium castaneum] -- -- -- -- -- K08187 SLC16A10 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K08187 Q91Y77 932 8.3e-99 Monocarboxylate transporter 10 OS=Rattus norvegicus GN=Slc16a10 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.24195 BP_3 240.00 7.07 1927 642931695 XP_008196691.1 404 1.8e-36 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24196 BP_3 118.89 1.34 4557 642931695 XP_008196691.1 301 3.7e-24 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O55035 139 9.3e-07 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.24201 BP_3 583.59 19.08 1766 642914906 XP_008190438.1 1619 2.1e-177 PREDICTED: cytochrome c oxidase assembly protein COX15 homolog [Tribolium castaneum]>gi|642914908|ref|XP_971726.3| PREDICTED: cytochrome c oxidase assembly protein COX15 homolog [Tribolium castaneum]>gi|270001402|gb|EEZ97849.1| hypothetical protein TcasGA2_TC000219 [Tribolium castaneum] 768916438 XR_964517.1 62 2.7158e-21 PREDICTED: Takifugu rubripes cytochrome c oxidase assembly protein COX15 homolog (LOC101068591), transcript variant X2, misc_RNA K02259 COX15 cytochrome c oxidase assembly protein subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K02259 Q8BJ03 1028 3.0e-110 Cytochrome c oxidase assembly protein COX15 homolog OS=Mus musculus GN=Cox15 PE=2 SV=1 PF02628//PF00944 Cytochrome oxidase assembly protein//Alphavirus core protein GO:0006508//GO:0006784//GO:0055114 proteolysis//heme a biosynthetic process//oxidation-reduction process GO:0016627//GO:0004252 oxidoreductase activity, acting on the CH-CH group of donors//serine-type endopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2725 Cytochrome oxidase assembly factor COX15 Cluster-8309.24202 BP_3 1.00 7.27 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24203 BP_3 194.00 13.57 981 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24206 BP_3 182.10 6.72 1597 546682882 ERL92768.1 424 7.1e-39 hypothetical protein D910_10076 [Dendroctonus ponderosae] -- -- -- -- -- K18710 SLBP histone RNA hairpin-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K18710 Q9VAN6 266 6.1e-22 Histone RNA hairpin-binding protein OS=Drosophila melanogaster GN=Slbp PE=1 SV=1 PF15247 Histone RNA hairpin-binding protein RNA-binding domain -- -- GO:0003723 RNA binding -- -- KOG3934 Histone mRNA stem-loop binding protein Cluster-8309.24207 BP_3 22.35 0.46 2621 91080851 XP_971681.1 728 6.5e-74 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005416|gb|EFA01864.1| hypothetical protein TcasGA2_TC007467 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 488 1.8e-47 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF01637//PF01504//PF00005//PF03193//PF00437//PF00004//PF13304//PF01926 Archaeal ATPase//Phosphatidylinositol-4-phosphate 5-Kinase//ABC transporter//Protein of unknown function, DUF258//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006200//GO:0006810//GO:0046488 obsolete ATP catabolic process//transport//phosphatidylinositol metabolic process GO:0005524//GO:0003924//GO:0016887//GO:0005525//GO:0016307 ATP binding//GTPase activity//ATPase activity//GTP binding//phosphatidylinositol phosphate kinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.24208 BP_3 144.00 3.43 2315 226968621 YP_002808570.1 1527 1.3e-166 NADH dehydrogenase subunit 4 [Scylla paramamosain]>gi|225697857|gb|ACO07224.1| NADH dehydrogenase subunit 4 [Scylla paramamosain]>gi|403311096|gb|AFR34055.1| NADH dehydrogenase subunit 4 (mitochondrion) [Scylla paramamosain] 225697849 FJ827761.1 2315 0 Scylla paramamosain mitochondrion, complete genome K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P07707 884 1.9e-93 NADH-ubiquinone oxidoreductase chain 4 OS=Drosophila yakuba GN=mt:ND4 PE=3 SV=1 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L GO:0042773//GO:0055114 ATP synthesis coupled electron transport//oxidation-reduction process GO:0016491//GO:0016651 oxidoreductase activity//oxidoreductase activity, acting on NAD(P)H GO:0044425//GO:0005739 membrane part//mitochondrion KOG4845 NADH dehydrogenase, subunit 4 Cluster-8309.2421 BP_3 157.00 23.48 614 91091644 XP_970770.1 278 2.3e-22 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000890|gb|EEZ97337.1| hypothetical protein TcasGA2_TC011149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 202 6.2e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.24210 BP_3 32.00 5.41 577 356483027 CCE46016.1 681 4.0e-69 putative 40S ribosomal protein S12 [Nephrops norvegicus] 356483026 HE608882.1 285 9.23677e-146 Nephrops norvegicus mRNA for putative 40S ribosomal protein S12 (rpS12 gene) K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P84175 511 8.5e-51 40S ribosomal protein S12 OS=Gallus gallus GN=RPS12 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3406 40S ribosomal protein S12 Cluster-8309.24213 BP_3 182.00 4.07 2447 260799997 XP_002594923.1 439 2.0e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P17010 323 2.3e-28 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF02150//PF00096//PF13465//PF07649 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain//C1-like domain GO:0055114//GO:0006206//GO:0006144//GO:0006351 oxidation-reduction process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0047134//GO:0003677//GO:0003899 metal ion binding//protein-disulfide reductase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.24214 BP_3 25.41 0.48 2850 260799997 XP_002594923.1 439 2.3e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P17010 323 2.7e-28 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF07649//PF00096//PF13465//PF02150 C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006206//GO:0055114 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0003677//GO:0003899//GO:0047134//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//protein-disulfide reductase activity//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.24216 BP_3 75.32 1.61 2552 546677972 ERL88701.1 1744 9.8e-192 hypothetical protein D910_06083 [Dendroctonus ponderosae] 768424815 XM_011555075.1 112 6.33341e-49 PREDICTED: Plutella xylostella cytoplasmic protein NCK2 (LOC105384796), mRNA K07365 NCK NCK adaptor protein http://www.genome.jp/dbget-bin/www_bget?ko:K07365 P16333 853 8.4e-90 Cytoplasmic protein NCK1 OS=Homo sapiens GN=NCK1 PE=1 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains Cluster-8309.24217 BP_3 787.68 15.76 2700 189237088 XP_969702.2 1855 1.4e-204 PREDICTED: cytoplasmic protein NCK1 isoform X2 [Tribolium castaneum] 768424815 XM_011555075.1 112 6.70119e-49 PREDICTED: Plutella xylostella cytoplasmic protein NCK2 (LOC105384796), mRNA K07365 NCK NCK adaptor protein http://www.genome.jp/dbget-bin/www_bget?ko:K07365 P16333 853 8.9e-90 Cytoplasmic protein NCK1 OS=Homo sapiens GN=NCK1 PE=1 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains Cluster-8309.24218 BP_3 32.00 3.73 705 642928694 XP_008199741.1 207 4.5e-14 PREDICTED: microtubule-actin cross-linking factor 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24220 BP_3 12.00 1.39 708 755984476 XP_011310537.1 245 1.8e-18 PREDICTED: methylenetetrahydrofolate reductase isoform X2 [Fopius arisanus]>gi|755984480|ref|XP_011310538.1| PREDICTED: methylenetetrahydrofolate reductase isoform X2 [Fopius arisanus] -- -- -- -- -- K00297 metF, MTHFR methylenetetrahydrofolate reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00297 Q9SE60 217 1.3e-16 Methylenetetrahydrofolate reductase 1 OS=Arabidopsis thaliana GN=MTHFR1 PE=1 SV=1 PF02219 Methylenetetrahydrofolate reductase GO:0046653//GO:0006555//GO:0055114 tetrahydrofolate metabolic process//methionine metabolic process//oxidation-reduction process GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity -- -- KOG0564 5,10-methylenetetrahydrofolate reductase Cluster-8309.24223 BP_3 14.00 3.18 504 478259891 ENN79701.1 136 5.5e-06 hypothetical protein YQE_03854, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02219 Methylenetetrahydrofolate reductase GO:0055114//GO:0006555//GO:0046653 oxidation-reduction process//methionine metabolic process//tetrahydrofolate metabolic process GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity -- -- -- -- Cluster-8309.24224 BP_3 701.00 11.51 3228 546674737 ERL86046.1 987 7.5e-104 hypothetical protein D910_03460 [Dendroctonus ponderosae] -- -- -- -- -- K09572 FKBP6 FK506-binding protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09572 Q9W1I9 409 3.2e-38 Inactive peptidyl-prolyl cis-trans isomerase shutdown OS=Drosophila melanogaster GN=shu PE=1 SV=1 PF13414//PF00254 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.24227 BP_3 15.50 0.32 2596 861623934 KMQ88136.1 146 2.0e-06 hypothetical protein RF55_12429 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24228 BP_3 27.16 0.32 4327 642930067 XP_008196236.1 3292 0.0e+00 PREDICTED: nephrin-like [Tribolium castaneum] 642930066 XM_008198014.1 458 0 PREDICTED: Tribolium castaneum nephrin-like (LOC663423), mRNA -- -- -- -- A2AJ76 208 8.8e-15 Hemicentin-2 OS=Mus musculus GN=Hmcn2 PE=2 SV=1 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24229 BP_3 109.05 2.03 2876 190702371 ACE75264.1 1977 1.1e-218 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24231 BP_3 2.00 1.78 339 780642694 XP_011688399.1 203 6.3e-14 PREDICTED: uncharacterized protein LOC105450313 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24232 BP_3 107.91 2.01 2883 190702371 ACE75264.1 1967 1.5e-217 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.24234 BP_3 520.10 9.38 2965 815769669 XP_012234959.1 1559 3.2e-170 PREDICTED: uncharacterized protein LOC105679478 [Linepithema humile] -- -- -- -- -- -- -- -- -- P34457 323 2.8e-28 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF02888//PF13683//PF00665 Calmodulin binding domain//Integrase core domain//Integrase core domain GO:0006813//GO:0015074 potassium ion transport//DNA integration GO:0015269//GO:0005516 calcium-activated potassium channel activity//calmodulin binding GO:0016021 integral component of membrane -- -- Cluster-8309.24235 BP_3 1.00 2.52 287 607355635 EZA50197.1 133 7.0e-06 hypothetical protein X777_11336 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24236 BP_3 498.52 2.40 10283 759070124 XP_011344632.1 2644 1.7e-295 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08398//PF01637//PF13912//PF00910//PF02913 Parvovirus coat protein VP1//Archaeal ATPase//C2H2-type zinc finger//RNA helicase//FAD linked oxidases, C-terminal domain -- -- GO:0003724//GO:0046872//GO:0050660//GO:0005198//GO:0003824//GO:0005524//GO:0003723 RNA helicase activity//metal ion binding//flavin adenine dinucleotide binding//structural molecule activity//catalytic activity//ATP binding//RNA binding GO:0019028 viral capsid -- -- Cluster-8309.24237 BP_3 8.00 2.31 458 815765017 XP_012214528.1 528 1.8e-51 PREDICTED: uncharacterized protein LOC105667333, partial [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.24238 BP_3 3.00 3.03 331 607355635 EZA50197.1 205 3.6e-14 hypothetical protein X777_11336 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24239 BP_3 11123.48 53.93 10233 759070124 XP_011344632.1 2644 1.7e-295 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00910//PF02913//PF01637//PF13912//PF08398 RNA helicase//FAD linked oxidases, C-terminal domain//Archaeal ATPase//C2H2-type zinc finger//Parvovirus coat protein VP1 -- -- GO:0050660//GO:0046872//GO:0003724//GO:0005524//GO:0003824//GO:0003723//GO:0005198 flavin adenine dinucleotide binding//metal ion binding//RNA helicase activity//ATP binding//catalytic activity//RNA binding//structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.2424 BP_3 29.44 0.56 2832 565412062 BAO20822.1 2453 6.7e-274 taurine transporter [Euphausia superba] 634893721 XM_007957172.1 70 1.56612e-25 PREDICTED: Orycteropus afer afer solute carrier family 6 (neurotransmitter transporter), member 8 (SLC6A8), transcript variant X3, mRNA K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 P31646 1550 1.4e-170 Sodium- and chloride-dependent GABA transporter 2 OS=Rattus norvegicus GN=Slc6a13 PE=1 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3660 Sodium-neurotransmitter symporter Cluster-8309.24242 BP_3 14.33 0.54 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10538 Immunoreceptor tyrosine-based activation motif GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.24243 BP_3 2.17 0.93 403 478256356 ENN76546.1 245 1.0e-18 hypothetical protein YQE_06997, partial [Dendroctonus ponderosae]>gi|546680785|gb|ERL90991.1| hypothetical protein D910_08333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P17789 160 3.0e-10 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24245 BP_3 64.78 2.02 1834 675366016 KFM58918.1 273 2.6e-21 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24246 BP_3 41.14 1.30 1821 675366016 KFM58918.1 235 6.6e-17 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24247 BP_3 111.35 2.36 2563 542218021 XP_005449110.1 167 7.2e-09 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like [Oreochromis niloticus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07710 P53 tetramerisation motif GO:0051262 protein tetramerization -- -- -- -- -- -- Cluster-8309.24248 BP_3 104.19 1.92 2911 542218021 XP_005449110.1 167 8.2e-09 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like [Oreochromis niloticus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03502 Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279 cell outer membrane -- -- Cluster-8309.24249 BP_3 16.08 0.79 1273 675366016 KFM58918.1 246 2.5e-18 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24250 BP_3 16.00 0.32 2683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24253 BP_3 10.00 0.31 1855 642926562 XP_008194921.1 831 5.3e-86 PREDICTED: fasciclin-1-like [Tribolium castaneum]>gi|270009110|gb|EFA05558.1| hypothetical protein TcasGA2_TC015746 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 500 5.2e-49 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24255 BP_3 3.00 0.72 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2426 BP_3 222.00 3.65 3221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03967 Photosynthetic reaction centre, H-chain N-terminal region GO:0006118//GO:0019684 obsolete electron transport//photosynthesis, light reaction GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GO:0030077 plasma membrane light-harvesting complex -- -- Cluster-8309.24260 BP_3 227.97 13.01 1136 270010525 EFA06973.1 213 1.5e-14 hypothetical protein TcasGA2_TC009933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24263 BP_3 53.66 3.03 1145 270013391 EFA09839.1 1829 6.1e-202 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 199 1.21219e-97 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P0C6B8 206 4.0e-15 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus GN=Svep1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.24265 BP_3 684.39 3.74 9117 642915919 XP_008190810.1 5228 0.0e+00 PREDICTED: protein retinal degeneration B isoform X2 [Tribolium castaneum] 642915918 XM_008192588.1 901 0 PREDICTED: Tribolium castaneum protein retinal degeneration B (LOC655106), transcript variant X4, mRNA -- -- -- -- P43125 3836 0.0e+00 Protein retinal degeneration B OS=Drosophila melanogaster GN=rdgB PE=1 SV=2 PF02480//PF03767//PF07354//PF13895//PF02121//PF02862 Alphaherpesvirus glycoprotein E//HAD superfamily, subfamily IIIB (Acid phosphatase)//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Phosphatidylinositol transfer protein//DDHD domain GO:0006810//GO:0019497//GO:0007339//GO:0006771 transport//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity GO:0016020//GO:0005622//GO:0005576 membrane//intracellular//extracellular region KOG3668 Phosphatidylinositol transfer protein Cluster-8309.24269 BP_3 90.67 1.79 2728 91090278 XP_970876.1 767 2.0e-78 PREDICTED: cell division control protein 42 homolog [Tribolium castaneum]>gi|270014293|gb|EFA10741.1| hypothetical protein TcasGA2_TC012434 [Tribolium castaneum] -- -- -- -- -- K07865 RHOU, WRCH1 Ras homolog gene family, member U http://www.genome.jp/dbget-bin/www_bget?ko:K07865 Q9EQT3 457 7.4e-44 Rho-related GTP-binding protein RhoU OS=Mus musculus GN=Rhou PE=2 SV=1 PF08477//PF03193//PF01926//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0016020//GO:0005622 membrane//intracellular KOG0393 Ras-related small GTPase, Rho type Cluster-8309.24273 BP_3 63.31 1.20 2831 642916439 XP_008191027.1 1004 7.0e-106 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 430 1.0e-40 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF08702//PF02601//PF09392//PF09036//PF02184//PF01496//PF05478//PF05929//PF00606//PF00046//PF11744//PF05073//PF04111//PF06814//PF08651//PF10459 Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Bcr-Abl oncoprotein oligomerisation domain//HAT (Half-A-TPR) repeat//V-type ATPase 116kDa subunit family//Prominin//Phage capsid scaffolding protein (GPO) serine peptidase//Herpesvirus Glycoprotein B//Homeobox domain//Aluminium activated malate transporter//Baculovirus P24 capsid protein//Autophagy protein Apg6//Lung seven transmembrane receptor//DASH complex subunit Duo1//Peptidase S46 GO:0006914//GO:0009069//GO:0051258//GO:0006468//GO:0009405//GO:0007165//GO:0015031//GO:0007067//GO:0015743//GO:0015991//GO:0006308//GO:0019069//GO:0015992//GO:0006396//GO:0016310//GO:0030168 autophagy//serine family amino acid metabolic process//protein polymerization//protein phosphorylation//pathogenesis//signal transduction//protein transport//mitotic nuclear division//malate transport//ATP hydrolysis coupled proton transport//DNA catabolic process//viral capsid assembly//proton transport//RNA processing//phosphorylation//platelet activation GO:0005096//GO:0070009//GO:0015078//GO:0008855//GO:0003677//GO:0004674//GO:0005102//GO:0008239//GO:0030674 GTPase activator activity//serine-type aminopeptidase activity//hydrogen ion transmembrane transporter activity//exodeoxyribonuclease VII activity//DNA binding//protein serine/threonine kinase activity//receptor binding//dipeptidyl-peptidase activity//protein binding, bridging GO:0016021//GO:0042729//GO:0005622//GO:0033179//GO:0016020//GO:0019028//GO:0005577//GO:0009318//GO:0072686 integral component of membrane//DASH complex//intracellular//proton-transporting V-type ATPase, V0 domain//membrane//viral capsid//fibrinogen complex//exodeoxyribonuclease VII complex//mitotic spindle KOG3850 Predicted membrane protein Cluster-8309.24274 BP_3 5.00 1.02 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24275 BP_3 22.73 0.42 2891 642916441 XP_008191028.1 1909 8.2e-211 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 810 9.2e-85 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF02601//PF08702//PF02184//PF01496//PF05073//PF05531//PF05929//PF05478 Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//HAT (Half-A-TPR) repeat//V-type ATPase 116kDa subunit family//Baculovirus P24 capsid protein//Nucleopolyhedrovirus P10 protein//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin GO:0019069//GO:0006308//GO:0030168//GO:0015991//GO:0006396//GO:0015992//GO:0051258//GO:0007165 viral capsid assembly//DNA catabolic process//platelet activation//ATP hydrolysis coupled proton transport//RNA processing//proton transport//protein polymerization//signal transduction GO:0030674//GO:0008855//GO:0015078//GO:0005102 protein binding, bridging//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//receptor binding GO:0033179//GO:0005577//GO:0005622//GO:0009318//GO:0019028//GO:0016021 proton-transporting V-type ATPase, V0 domain//fibrinogen complex//intracellular//exodeoxyribonuclease VII complex//viral capsid//integral component of membrane KOG3850 Predicted membrane protein Cluster-8309.24276 BP_3 311.34 8.42 2074 642916441 XP_008191028.1 188 2.1e-11 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24277 BP_3 66.75 3.62 1180 642916447 XP_008191031.1 858 2.5e-89 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 430 4.3e-41 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF13184//PF12919//PF00606//PF00046//PF08702 NusA-like KH domain//TcdA/TcdB catalytic glycosyltransferase domain//Herpesvirus Glycoprotein B//Homeobox domain//Fibrinogen alpha/beta chain family GO:0030168//GO:0007165//GO:0051258 platelet activation//signal transduction//protein polymerization GO:0005102//GO:0030674//GO:0003677//GO:0003723//GO:0016757 receptor binding//protein binding, bridging//DNA binding//RNA binding//transferase activity, transferring glycosyl groups GO:0016020//GO:0005577 membrane//fibrinogen complex KOG3850 Predicted membrane protein Cluster-8309.24283 BP_3 71.00 2.08 1938 642923802 XP_008193889.1 267 1.4e-20 PREDICTED: uncharacterized protein LOC103313152 [Tribolium castaneum]>gi|270006930|gb|EFA03378.1| hypothetical protein TcasGA2_TC013364 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24284 BP_3 385.66 11.18 1955 91083321 XP_974829.1 1054 7.7e-112 PREDICTED: neuroguidin [Tribolium castaneum]>gi|270007746|gb|EFA04194.1| hypothetical protein TcasGA2_TC014443 [Tribolium castaneum] -- -- -- -- -- K14765 NGDN, LCP5 U3 small nucleolar ribonucleoprotein protein LCP5 http://www.genome.jp/dbget-bin/www_bget?ko:K14765 Q8NEJ9 463 1.1e-44 Neuroguidin OS=Homo sapiens GN=NGDN PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3117 Protein involved in rRNA processing Cluster-8309.24286 BP_3 163.89 3.31 2676 270001924 EEZ98371.1 967 1.3e-101 hypothetical protein TcasGA2_TC000830 [Tribolium castaneum] 194742811 XM_001953858.1 123 5.10101e-55 Drosophila ananassae GF17008 (Dana\GF17008), mRNA -- -- -- -- Q68DU8 428 1.7e-40 BTB/POZ domain-containing protein KCTD16 OS=Homo sapiens GN=KCTD16 PE=2 SV=1 PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- KOG2723 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.24287 BP_3 16.00 0.45 1996 478250794 ENN71286.1 2217 1.1e-246 hypothetical protein YQE_12211, partial [Dendroctonus ponderosae] 590705143 XM_007047292.1 35 3.14265e-06 Theobroma cacao Mediator complex, subunit Med10 isoform 4 (TCM_000672) mRNA, complete cds K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 Q960Z0 1397 5.4e-153 Kinesin-like protein Klp10A OS=Drosophila melanogaster GN=Klp10A PE=1 SV=1 PF00225//PF01857 Kinesin motor domain//Retinoblastoma-associated protein B domain GO:0007017//GO:0051726//GO:0007018 microtubule-based process//regulation of cell cycle//microtubule-based movement GO:0008017//GO:0003777//GO:0005524 microtubule binding//microtubule motor activity//ATP binding GO:0005874//GO:0045298//GO:0005634 microtubule//tubulin complex//nucleus KOG0246 Kinesin-like protein Cluster-8309.24289 BP_3 211.72 4.60 2511 91076692 XP_971784.1 851 3.4e-88 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 [Tribolium castaneum]>gi|270001889|gb|EEZ98336.1| hypothetical protein TcasGA2_TC000790 [Tribolium castaneum] -- -- -- -- -- K10768 ALKBH6 alkylated DNA repair protein alkB homolog 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10768 Q6IQE9 559 1.0e-55 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Danio rerio GN=alkbh6 PE=2 SV=1 PF05615//PF03171//PF07361 Tho complex subunit 7//2OG-Fe(II) oxygenase superfamily//Cytochrome b562 GO:0055114//GO:0006118//GO:0022900//GO:0006397 oxidation-reduction process//obsolete electron transport//electron transport chain//mRNA processing GO:0020037//GO:0005506//GO:0016706//GO:0009055//GO:0016491 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//electron carrier activity//oxidoreductase activity GO:0000445//GO:0042597 THO complex part of transcription export complex//periplasmic space KOG3200 Uncharacterized conserved protein Cluster-8309.24291 BP_3 39.00 0.31 6264 29134779 BAC66140.1 8128 0.0e+00 projectin [Procambarus clarkii] 29134778 AB055927.1 1873 0 Procambarus clarkii mRNA for projectin, complete cds -- -- -- -- Q23551 3190 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF00041//PF13895//PF16656//PF07714//PF00069//PF06293 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0019497//GO:0006771 protein phosphorylation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0005524//GO:0046872//GO:0004672//GO:0016773//GO:0003993 protein binding//ATP binding//metal ion binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//acid phosphatase activity GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.24292 BP_3 1086.77 15.56 3659 91079660 XP_966451.1 3241 0.0e+00 PREDICTED: ubiquitin conjugation factor E4 A [Tribolium castaneum]>gi|270003363|gb|EEZ99810.1| hypothetical protein TcasGA2_TC002590 [Tribolium castaneum] -- -- -- -- -- K10596 UBE4A ubiquitin conjugation factor E4 A http://www.genome.jp/dbget-bin/www_bget?ko:K10596 A5PKG6 1540 2.6e-169 Ubiquitin conjugation factor E4 A OS=Bos taurus GN=UBE4A PE=2 SV=1 PF04564//PF10408 U-box domain//Ubiquitin elongating factor core GO:0006511//GO:0044267//GO:0016567 ubiquitin-dependent protein catabolic process//cellular protein metabolic process//protein ubiquitination GO:0034450//GO:0004842 ubiquitin-ubiquitin ligase activity//ubiquitin-protein transferase activity GO:0000151 ubiquitin ligase complex KOG2042 Ubiquitin fusion degradation protein-2 Cluster-8309.24293 BP_3 17.00 0.45 2105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24295 BP_3 83.40 0.66 6390 270007379 EFA03827.1 8236 0.0e+00 hypothetical protein TcasGA2_TC013942 [Tribolium castaneum] 769853772 XM_011640095.1 123 1.22629e-54 PREDICTED: Pogonomyrmex barbatus dedicator of cytokinesis protein 7 (LOC105428043), mRNA -- -- -- -- Q96N67 4645 0.0e+00 Dedicator of cytokinesis protein 7 OS=Homo sapiens GN=DOCK7 PE=1 SV=4 PF05412 Equine arterivirus Nsp2-type cysteine proteinase GO:0016032//GO:0019082 viral process//viral protein processing -- -- -- -- KOG1997 PH domain-containing protein Cluster-8309.24296 BP_3 31.18 0.34 4664 642922636 XP_971090.3 2313 1.9e-257 PREDICTED: uncharacterized protein LOC659719 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 Q6P7W0 366 4.5e-33 Sentrin-specific protease 6 OS=Mus musculus GN=Senp6 PE=2 SV=3 PF02902//PF02944 Ulp1 protease family, C-terminal catalytic domain//BESS motif GO:0006508 proteolysis GO:0008234//GO:0003677 cysteine-type peptidase activity//DNA binding -- -- KOG0779 Protease, Ulp1 family Cluster-8309.24298 BP_3 9.00 4.69 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24299 BP_3 534.14 23.53 1386 642921679 XP_969670.3 1346 7.5e-146 PREDICTED: sulfatase-modifying factor 1 [Tribolium castaneum] -- -- -- -- -- K13444 SUMF1, FGE sulfatase modifying factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13444 Q8R0F3 923 3.5e-98 Sulfatase-modifying factor 1 OS=Mus musculus GN=Sumf1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.243 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24300 BP_3 93.00 3.69 1507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24304 BP_3 489.64 6.42 3970 642916252 XP_008190947.1 2331 1.3e-259 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 94 1.00368e-38 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 582 3.5e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF13405//PF00036//PF00018//PF13499//PF14604//PF12763 EF-hand domain//EF hand//SH3 domain//EF-hand domain pair//Variant SH3 domain//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.24305 BP_3 673.92 10.45 3399 642932050 XP_008196838.1 1190 2.3e-127 PREDICTED: DCN1-like protein 3 [Tribolium castaneum] 817192303 XM_012416161.1 170 4.84532e-81 PREDICTED: Orussus abietinus DCN1-like protein 3 (LOC105694968), transcript variant X3, mRNA K17823 DCUN1D3 DCN1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17823 Q5E9V1 594 1.2e-59 DCN1-like protein 3 OS=Bos taurus GN=DCUN1D3 PE=2 SV=1 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3077 Uncharacterized conserved protein Cluster-8309.24307 BP_3 6.03 0.32 1187 478254922 ENN75156.1 305 3.3e-25 hypothetical protein YQE_08269, partial [Dendroctonus ponderosae]>gi|546673353|gb|ERL84979.1| hypothetical protein D910_02402 [Dendroctonus ponderosae] -- -- -- -- -- K17783 ERV1, GFER, ALR mitochondrial FAD-linked sulfhydryl oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K17783 P55789 218 1.7e-16 FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens GN=GFER PE=1 SV=2 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3355 Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins Cluster-8309.24308 BP_3 182.97 23.56 666 478254922 ENN75156.1 707 4.5e-72 hypothetical protein YQE_08269, partial [Dendroctonus ponderosae]>gi|546673353|gb|ERL84979.1| hypothetical protein D910_02402 [Dendroctonus ponderosae] -- -- -- -- -- K17783 ERV1, GFER, ALR mitochondrial FAD-linked sulfhydryl oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K17783 P55789 414 1.7e-39 FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens GN=GFER PE=1 SV=2 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3355 Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins Cluster-8309.2431 BP_3 10.00 0.40 1503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24310 BP_3 816.36 16.19 2722 478256708 ENN76890.1 2386 3.8e-266 hypothetical protein YQE_06731, partial [Dendroctonus ponderosae] -- -- -- -- -- K08766 CPT2 carnitine O-palmitoyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08766 Q5U3U3 1611 1.1e-177 Carnitine O-palmitoyltransferase 2, mitochondrial OS=Danio rerio GN=cpt2 PE=2 SV=2 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3719 Carnitine O-acyltransferase CPT2/YAT1 Cluster-8309.24311 BP_3 152.00 9.33 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24315 BP_3 106.29 1.65 3400 478256893 ENN77062.1 359 5.2e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 5.3e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF01844//PF07975//PF00096//PF13465 HNH endonuclease//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0003676//GO:0004519//GO:0008270//GO:0046872 nucleic acid binding//endonuclease activity//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.24318 BP_3 15.36 0.72 1315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24319 BP_3 68.85 0.48 7148 642911198 XP_008199568.1 2708 4.5e-303 PREDICTED: solute carrier family 12 member 4 isoform X2 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.32958e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2008 2.8e-223 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF13520//PF05038//PF03522//PF00324 Amino acid permease//Cytochrome Cytochrome b558 alpha-subunit//Solute carrier family 12//Amino acid permease GO:0003333//GO:0006811//GO:0006865//GO:0055085//GO:0006810 amino acid transmembrane transport//ion transport//amino acid transport//transmembrane transport//transport GO:0020037//GO:0015171//GO:0005215 heme binding//amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.24320 BP_3 116.47 2.55 2493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24322 BP_3 17.00 5.90 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24323 BP_3 22.47 0.39 3080 270009469 EFA05917.1 666 1.2e-66 hypothetical protein TcasGA2_TC008733 [Tribolium castaneum] -- -- -- -- -- K08658 RCE1, FACE2 prenyl protein peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08658 Q9U1H8 420 1.6e-39 CAAX prenyl protease 2 OS=Drosophila melanogaster GN=Sras PE=2 SV=3 PF07127//PF02517//PF04117 Late nodulin protein//CAAX protease self-immunity//Mpv17 / PMP22 family GO:0009878 nodule morphogenesis GO:0046872 metal ion binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.24324 BP_3 105.64 1.82 3094 546672114 ERL84135.1 1143 5.8e-122 hypothetical protein D910_01486 [Dendroctonus ponderosae]>gi|546675290|gb|ERL86521.1| hypothetical protein D910_03927 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NAG6 531 2.2e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.24326 BP_3 45.99 2.13 1331 91091486 XP_968262.1 699 7.6e-71 PREDICTED: phospholipase A1 [Tribolium castaneum]>gi|270000939|gb|EEZ97386.1| hypothetical protein TcasGA2_TC011212 [Tribolium castaneum] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q6Q252 289 1.1e-24 Phospholipase A1 1 OS=Polistes dominula PE=2 SV=1 PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.24327 BP_3 325.29 27.26 867 642934204 XP_008199651.1 677 1.8e-68 PREDICTED: gem-associated protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O42260 301 2.9e-26 Gem-associated protein 2 OS=Xenopus laevis GN=gemin2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24328 BP_3 24.41 0.35 3695 270008598 EFA05046.1 1993 1.9e-220 hypothetical protein TcasGA2_TC015138 [Tribolium castaneum] 471381863 XM_004378665.1 250 1.77911e-125 PREDICTED: Trichechus manatus latirostris adaptor-related protein complex 3, delta 1 subunit (LOC101342845), mRNA K12396 AP3D1 AP-3 complex subunit delta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12396 O54774 1347 6.3e-147 AP-3 complex subunit delta-1 OS=Mus musculus GN=Ap3d1 PE=1 SV=1 PF01602//PF02985//PF00511//PF01701 Adaptin N terminal region//HEAT repeat//E2 (early) protein, C terminal//Photosystem I reaction centre subunit IX / PsaJ GO:0006355//GO:0016192//GO:0006886//GO:0006275//GO:0015979 regulation of transcription, DNA-templated//vesicle-mediated transport//intracellular protein transport//regulation of DNA replication//photosynthesis GO:0003700//GO:0005515//GO:0003677 transcription factor activity, sequence-specific DNA binding//protein binding//DNA binding GO:0030117//GO:0009522//GO:0005667//GO:0042025 membrane coat//photosystem I//transcription factor complex//host cell nucleus KOG1059 Vesicle coat complex AP-3, delta subunit Cluster-8309.24329 BP_3 779.86 12.37 3331 270008598 EFA05046.1 3334 0.0e+00 hypothetical protein TcasGA2_TC015138 [Tribolium castaneum] 795332906 XM_012072956.1 377 0 PREDICTED: Cercocebus atys adaptor-related protein complex 3, delta 1 subunit (AP3D1), mRNA K12396 AP3D1 AP-3 complex subunit delta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12396 P54362 2553 8.2e-287 AP-3 complex subunit delta OS=Drosophila melanogaster GN=g PE=1 SV=4 PF02985//PF01602//PF11698 HEAT repeat//Adaptin N terminal region//V-ATPase subunit H GO:0006886//GO:0015991//GO:0016192 intracellular protein transport//ATP hydrolysis coupled proton transport//vesicle-mediated transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0030117//GO:0000221 membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain KOG1059 Vesicle coat complex AP-3, delta subunit Cluster-8309.2433 BP_3 1.00 0.33 436 270008852 EFA05300.1 329 2.0e-28 hypothetical protein TcasGA2_TC015457 [Tribolium castaneum] -- -- -- -- -- K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 O88703 175 5.9e-12 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Mus musculus GN=Hcn2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.24332 BP_3 11.00 0.54 1278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24335 BP_3 47.29 0.41 5850 91094819 XP_970889.1 366 1.4e-31 PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|642922887|ref|XP_008200438.1| PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|270006570|gb|EFA03018.1| hypothetical protein TcasGA2_TC010441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02943 Ferredoxin thioredoxin reductase catalytic beta chain GO:0055114 oxidation-reduction process GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors -- -- -- -- Cluster-8309.24336 BP_3 85.97 3.18 1596 478259274 ENN79176.1 252 6.2e-19 hypothetical protein YQE_04360, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24337 BP_3 11.31 0.43 1552 642929392 XP_008195817.1 488 2.6e-46 PREDICTED: neogenin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06583 Neogenin C-terminus -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.24338 BP_3 457.03 2.56 8903 546685536 ERL95023.1 2501 5.7e-279 hypothetical protein D910_12293 [Dendroctonus ponderosae] 780637936 XM_011688946.1 160 4.62547e-75 PREDICTED: Wasmannia auropunctata LIM domain kinase 1 (LOC105449641), transcript variant X2, mRNA K05743 LIMK1 LIM domain kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05743 Q8IR79 1419 6.8e-155 LIM domain kinase 1 OS=Drosophila melanogaster GN=LIMK1 PE=1 SV=1 PF16740//PF00170//PF04871//PF00069//PF07714//PF07544//PF08289//PF06293//PF06160//PF10473//PF10392//PF05929//PF05478//PF00595//PF05531//PF07851//PF06009//PF16331//PF02601//PF04513//PF04728//PF01621//PF00412 Spindle and kinetochore-associated protein 2//bZIP transcription factor//Uso1 / p115 like vesicle tethering protein, C terminal region//Protein kinase domain//Protein tyrosine kinase//RNA polymerase II transcription mediator complex subunit 9//Influenza Matrix protein (M1) C-terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Golgi transport complex subunit 5//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin//PDZ domain (Also known as DHR or GLGF)//Nucleopolyhedrovirus P10 protein//TMPIT-like protein//Laminin Domain II//TolA binding protein trimerisation//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//Lipoprotein leucine-zipper//Cell fusion glycoprotein K//LIM domain GO:0007155//GO:0006308//GO:0019069//GO:0070206//GO:0006886//GO:0006468//GO:0031110//GO:0007067//GO:0006355//GO:0000090//GO:0015031//GO:0007059//GO:0006891//GO:0000921//GO:0051301//GO:0006357 cell adhesion//DNA catabolic process//viral capsid assembly//protein trimerization//intracellular protein transport//protein phosphorylation//regulation of microtubule polymerization or depolymerization//mitotic nuclear division//regulation of transcription, DNA-templated//mitotic anaphase//protein transport//chromosome segregation//intra-Golgi vesicle-mediated transport//septin ring assembly//cell division//regulation of transcription from RNA polymerase II promoter GO:0003723//GO:0005515//GO:0008855//GO:0008017//GO:0042803//GO:0005198//GO:0008565//GO:0008270//GO:0043565//GO:0001104//GO:0016773//GO:0004672//GO:0005524//GO:0045502//GO:0008134//GO:0003700 RNA binding//protein binding//exodeoxyribonuclease VII activity//microtubule binding//protein homodimerization activity//structural molecule activity//protein transporter activity//zinc ion binding//sequence-specific DNA binding//RNA polymerase II transcription cofactor activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding//dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding GO:0019867//GO:0019031//GO:0016020//GO:0000940//GO:0017119//GO:0016021//GO:0005940//GO:0005876//GO:0005737//GO:0030286//GO:0016592//GO:0005667//GO:0019028//GO:0045298//GO:0009318 outer membrane//viral envelope//membrane//condensed chromosome outer kinetochore//Golgi transport complex//integral component of membrane//septin ring//spindle microtubule//cytoplasm//dynein complex//mediator complex//transcription factor complex//viral capsid//tubulin complex//exodeoxyribonuclease VII complex -- -- Cluster-8309.24339 BP_3 147.00 3.28 2454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2434 BP_3 715.37 26.42 1597 478254273 ENN74527.1 196 1.9e-12 hypothetical protein YQE_08851, partial [Dendroctonus ponderosae]>gi|546671467|gb|ERL83769.1| hypothetical protein D910_00997 [Dendroctonus ponderosae]>gi|546672146|gb|ERL84147.1| hypothetical protein D910_01508 [Dendroctonus ponderosae]>gi|546674915|gb|ERL86197.1| hypothetical protein D910_03608 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10174//PF07730//PF11896//PF02970//PF06009//PF04111 RIM-binding protein of the cytomatrix active zone//Histidine kinase//Domain of unknown function (DUF3416)//Tubulin binding cofactor A//Laminin Domain II//Autophagy protein Apg6 GO:0005975//GO:0007021//GO:0007155//GO:0016310//GO:0006914//GO:0000160 carbohydrate metabolic process//tubulin complex assembly//cell adhesion//phosphorylation//autophagy//phosphorelay signal transduction system GO:0051082//GO:0015631//GO:0046983//GO:0004553//GO:0000155 unfolded protein binding//tubulin binding//protein dimerization activity//hydrolase activity, hydrolyzing O-glycosyl compounds//phosphorelay sensor kinase activity GO:0048786//GO:0009365//GO:0045298//GO:0016021 presynaptic active zone//protein histidine kinase complex//tubulin complex//integral component of membrane -- -- Cluster-8309.24342 BP_3 165.47 1.51 5587 270014870 EFA11318.1 336 4.0e-28 hypothetical protein TcasGA2_TC010857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24343 BP_3 154.36 1.49 5271 270014870 EFA11318.1 339 1.7e-28 hypothetical protein TcasGA2_TC010857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24345 BP_3 413.51 10.65 2163 189235172 XP_001811552.1 2109 3.9e-234 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum]>gi|270003118|gb|EEZ99565.1| hypothetical protein TcasGA2_TC001549 [Tribolium castaneum] 749791080 XM_011150425.1 87 4.22814e-35 PREDICTED: Harpegnathos saltator discoidin domain-containing receptor 2-like (LOC105188791), transcript variant X2, mRNA K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 687 1.3e-70 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF02480 Alphaherpesvirus glycoprotein E GO:0007155 cell adhesion -- -- GO:0016020 membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.24347 BP_3 520.00 8.66 3186 478253879 ENN74171.1 189 2.5e-11 hypothetical protein YQE_09144, partial [Dendroctonus ponderosae]>gi|546684688|gb|ERL94305.1| hypothetical protein D910_11586 [Dendroctonus ponderosae] 642939598 XM_008196266.1 61 1.77694e-20 PREDICTED: Tribolium castaneum uncharacterized LOC103313285 (LOC103313285), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF04771 Chicken anaemia virus VP-3 protein GO:0019051 induction by virus of host apoptotic process -- -- GO:0042025 host cell nucleus -- -- Cluster-8309.24352 BP_3 617.38 10.93 3015 546678907 ERL89445.1 1619 3.6e-177 hypothetical protein D910_06812 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 875 2.8e-92 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF06756//PF00033//PF01073//PF01370 Male sterility protein//Chorion protein S19 C-terminal//Cytochrome b/b6/petB//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0022904//GO:0008210//GO:0007275 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//respiratory electron transport chain//estrogen metabolic process//multicellular organismal development GO:0080019//GO:0003824//GO:0050662//GO:0003854//GO:0016616 fatty-acyl-CoA reductase (alcohol-forming) activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016020//GO:0042600 membrane//chorion KOG1221 Acyl-CoA reductase Cluster-8309.24354 BP_3 56.65 0.71 4155 642932911 XP_008197183.1 2117 8.9e-235 PREDICTED: ankyrin repeat domain-containing protein 13D isoform X1 [Tribolium castaneum]>gi|270012473|gb|EFA08921.1| hypothetical protein TcasGA2_TC006628 [Tribolium castaneum] 645004819 XM_001604621.3 84 3.80648e-33 PREDICTED: Nasonia vitripennis ankyrin repeat domain-containing protein 13D (LOC100121088), mRNA -- -- -- -- Q6PD24 1360 2.2e-148 Ankyrin repeat domain-containing protein 13D OS=Mus musculus GN=Ankrd13d PE=2 SV=2 PF15306//PF00023//PF13606 LIN37//Ankyrin repeat//Ankyrin repeat GO:0007049 cell cycle GO:0005515 protein binding GO:0017053 transcriptional repressor complex KOG0522 Ankyrin repeat protein Cluster-8309.24357 BP_3 842.46 7.78 5514 91092132 XP_975744.1 4022 0.0e+00 PREDICTED: transportin-1 [Tribolium castaneum] 805820211 XM_012294805.1 405 0 PREDICTED: Megachile rotundata transportin-1 (LOC100876705), transcript variant X3, mRNA K18752 TNPO1 transportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K18752 Q8BFY9 3552 0.0e+00 Transportin-1 OS=Mus musculus GN=Tnpo1 PE=1 SV=2 PF01602//PF00514//PF03810//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//Importin-beta N-terminal domain//HEAT repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0008536 protein binding//Ran GTPase binding GO:0030117 membrane coat KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) Cluster-8309.24361 BP_3 71.30 0.76 4834 189236172 XP_967164.2 2056 1.2e-227 PREDICTED: WD repeat-containing and planar cell polarity effector protein fritz [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VQ36 600 3.4e-60 WD repeat-containing and planar cell polarity effector protein fritz OS=Drosophila melanogaster GN=frtz PE=2 SV=1 PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.24366 BP_3 10.36 0.48 1321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24367 BP_3 104.47 0.92 5791 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24368 BP_3 16.00 2.20 643 91083149 XP_971578.1 482 5.4e-46 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 209 1.0e-15 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089//PF05271 Trypsin//Tobravirus 2B protein GO:0019089//GO:0006508 transmission of virus//proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.24369 BP_3 2.00 0.41 527 820805526 AKG92754.1 260 2.4e-20 usf [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24371 BP_3 62.01 1.10 3020 642921355 XP_008192834.1 1707 2.3e-187 PREDICTED: uncharacterized protein LOC658985 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G5E8K6 233 7.7e-18 Monocarboxylate transporter 6 OS=Mus musculus GN=Slc16a5 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.24374 BP_3 134.41 1.82 3857 270003223 EEZ99670.1 2222 5.5e-247 hypothetical protein TcasGA2_TC002427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00514//PF11698//PF00651 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//BTB/POZ domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.24376 BP_3 69.00 8.33 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24377 BP_3 27.68 0.41 3533 642918312 XP_008191454.1 2864 0.0e+00 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.25685e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1903 2.0e-211 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.24378 BP_3 365.37 5.53 3478 642918312 XP_008191454.1 2864 0.0e+00 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.17417e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1917 4.8e-213 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.24379 BP_3 952.51 12.49 3968 91090312 XP_972241.1 1990 4.5e-220 PREDICTED: C-terminal-binding protein isoform X2 [Tribolium castaneum]>gi|270013805|gb|EFA10253.1| hypothetical protein TcasGA2_TC012453 [Tribolium castaneum] 642934911 XM_967148.3 534 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K04496 CTBP C-terminal binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04496 O46036 1752 7.4e-194 C-terminal-binding protein OS=Drosophila melanogaster GN=CtBP PE=1 SV=3 PF02826//PF03446//PF00389//PF03493 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit GO:0019521//GO:0055114//GO:0006098//GO:0008152//GO:0006813 D-gluconate metabolic process//oxidation-reduction process//pentose-phosphate shunt//metabolic process//potassium ion transport GO:0004616//GO:0016616//GO:0051287//GO:0015269 phosphogluconate dehydrogenase (decarboxylating) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//calcium-activated potassium channel activity GO:0016020 membrane KOG0067 Transcription factor CtBP Cluster-8309.2438 BP_3 13.00 2.71 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24382 BP_3 10.37 0.53 1227 242020221 XP_002430554.1 188 1.3e-11 conserved hypothetical protein [Pediculus humanus corporis]>gi|212515718|gb|EEB17816.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- K02370 EXTL3 alpha-1,4-N-acetylglucosaminyltransferase EXTL3 http://www.genome.jp/dbget-bin/www_bget?ko:K02370 Q9XZ08 178 7.5e-12 Exostosin-3 OS=Drosophila melanogaster GN=botv PE=1 SV=1 -- -- -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2264 Exostosin EXT1L Cluster-8309.24383 BP_3 24.31 0.70 1960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.24384 BP_3 46.70 1.05 2438 795011494 XP_011872774.1 369 2.6e-32 PREDICTED: uncharacterized protein LOC105564750, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.24387 BP_3 351.73 3.12 5720 270008864 EFA05312.1 1750 4.4e-192 hypothetical protein TcasGA2_TC015470 [Tribolium castaneum] 642937640 XM_965135.3 331 2.59324e-170 PREDICTED: Tribolium castaneum inverted formin-2 (LOC658775), mRNA -- -- -- -- Q9C0D6 714 2.5e-73 FH2 domain-containing protein 1 OS=Homo sapiens GN=FHDC1 PE=1 SV=2 PF06367//PF06371 Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0016043//GO:0030036 cellular component organization//actin cytoskeleton organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.24389 BP_3 6.00 0.59 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24391 BP_3 4.00 5.49 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24392 BP_3 329.28 4.38 3912 642910837 XP_971522.2 2303 2.3e-256 PREDICTED: probable DNA mismatch repair protein Msh6 [Tribolium castaneum] -- -- -- -- -- K08737 MSH6 DNA mismatch repair protein MSH6 http://www.genome.jp/dbget-bin/www_bget?ko:K08737 Q9VUM0 1519 7.6e-167 Probable DNA mismatch repair protein Msh6 OS=Drosophila melanogaster GN=Msh6 PE=1 SV=2 PF00488//PF01624//PF05190//PF00004//PF00995//PF00910//PF05192//PF05188 MutS domain V//MutS domain I//MutS family domain IV//ATPase family associated with various cellular activities (AAA)//Sec1 family//RNA helicase//MutS domain III//MutS domain II GO:0006904//GO:0016192//GO:0006298 vesicle docking involved in exocytosis//vesicle-mediated transport//mismatch repair GO:0003724//GO:0003723//GO:0005524//GO:0030983 RNA helicase activity//RNA binding//ATP binding//mismatched DNA binding -- -- KOG0217 Mismatch repair ATPase MSH6 (MutS family) Cluster-8309.24393 BP_3 298.00 11.29 1564 546679520 ERL89975.1 244 5.2e-18 hypothetical protein D910_07334 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24394 BP_3 135.91 1.82 3899 642934988 XP_967114.2 1320 2.2e-142 PREDICTED: protein fem-1 homolog CG6966 [Tribolium castaneum] 242011328 XM_002426360.1 61 2.17915e-20 Pediculus humanus corporis Sex-determining protein fem-1, putative, mRNA -- -- -- -- Q2T9K6 431 1.1e-40 Protein fem-1 homolog C OS=Xenopus laevis GN=fem1c PE=2 SV=1 PF05397//PF00023//PF01363//PF13606 Mediator complex subunit 15//Ankyrin repeat//FYVE zinc finger//Ankyrin repeat GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0005515//GO:0046872 RNA polymerase II transcription cofactor activity//protein binding//metal ion binding GO:0016592 mediator complex KOG0508 Ankyrin repeat protein Cluster-8309.24395 BP_3 299.09 5.48 2923 642934988 XP_967114.2 2574 6.4e-288 PREDICTED: protein fem-1 homolog CG6966 [Tribolium castaneum] 242011328 XM_002426360.1 61 1.62858e-20 Pediculus humanus corporis Sex-determining protein fem-1, putative, mRNA -- -- -- -- Q2T9K6 812 5.4e-85 Protein fem-1 homolog C OS=Xenopus laevis GN=fem1c PE=2 SV=1 PF05397//PF00023//PF13606//PF01363 Mediator complex subunit 15//Ankyrin repeat//Ankyrin repeat//FYVE zinc finger GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0005515//GO:0046872 RNA polymerase II transcription cofactor activity//protein binding//metal ion binding GO:0016592 mediator complex KOG0508 Ankyrin repeat protein Cluster-8309.24399 BP_3 51.00 2.45 1294 642913330 XP_008195282.1 1258 1.1e-135 PREDICTED: origin recognition complex subunit 2 [Tribolium castaneum]>gi|270001754|gb|EEZ98201.1| hypothetical protein TcasGA2_TC000631 [Tribolium castaneum] -- -- -- -- -- K02604 ORC2 origin recognition complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02604 Q24168 1015 7.0e-109 Origin recognition complex subunit 2 OS=Drosophila melanogaster GN=Orc2 PE=1 SV=2 PF04084 Origin recognition complex subunit 2 GO:0006260 DNA replication -- -- GO:0000808//GO:0005634 origin recognition complex//nucleus KOG2928 Origin recognition complex, subunit 2 Cluster-8309.24401 BP_3 176.00 18.27 756 91089859 XP_971110.1 584 9.4e-58 PREDICTED: B-cell CLL/lymphoma 7 protein family member A [Tribolium castaneum]>gi|270013648|gb|EFA10096.1| hypothetical protein TcasGA2_TC012275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XFY4 261 1.1e-21 B-cell CLL/lymphoma 7 protein family member A OS=Danio rerio GN=bcl7a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4095 Uncharacterized conserved protein (tumor-specific protein BCL7 in humans) Cluster-8309.24402 BP_3 92.58 3.47 1578 189234531 XP_967948.2 1282 2.3e-138 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K14425 SLC12A1, NKCC2 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14425 Q25479 1019 2.9e-109 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0055085//GO:0006810//GO:0006811 transmembrane transport//transport//ion transport GO:0005215 transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.24403 BP_3 4.03 0.52 664 642937480 XP_008198856.1 184 2.0e-11 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24404 BP_3 460.00 7.01 3454 -- -- -- -- -- 642934703 XM_008199556.1 74 1.14412e-27 PREDICTED: Tribolium castaneum protein numb (LOC661741), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24405 BP_3 11.57 0.39 1733 642933086 XP_008197254.1 1515 2.4e-165 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 1020 2.5e-109 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133//PF03171 Tubulin-tyrosine ligase family//2OG-Fe(II) oxygenase superfamily GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.24408 BP_3 33.15 0.39 4420 642915079 XP_008190402.1 3503 0.0e+00 PREDICTED: unconventional myosin-IXa isoform X2 [Tribolium castaneum] 768442001 XM_011564452.1 512 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q9Z1N3 1894 2.8e-210 Unconventional myosin-IXa OS=Rattus norvegicus GN=Myo9a PE=1 SV=1 PF00788//PF00437//PF01990//PF15177//PF00063 Ras association (RalGDS/AF-6) domain//Type II/IV secretion system protein//ATP synthase (F/14-kDa) subunit//Interleukin-28A//Myosin head (motor domain) GO:0050778//GO:0051607//GO:0006810//GO:0034220//GO:0007259//GO:0007165 positive regulation of immune response//defense response to virus//transport//ion transmembrane transport//JAK-STAT cascade//signal transduction GO:0005125//GO:0003774//GO:0005524 cytokine activity//motor activity//ATP binding GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.24409 BP_3 174.47 7.97 1347 727098876 AIY54294.1 1603 1.2e-175 actin 2 [Colaphellus bowringi] 605059338 KJ187399.1 192 1.11412e-93 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1508 4.9e-166 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.2441 BP_3 7.00 0.38 1184 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24410 BP_3 372.62 4.23 4537 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.54418e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 1.9e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF00278//PF10186 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.24411 BP_3 32.74 0.36 4707 270003228 EEZ99675.1 1637 4.6e-179 hypothetical protein TcasGA2_TC002432 [Tribolium castaneum] 605059338 KJ187399.1 241 2.2873e-120 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1310 1.6e-142 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF00278//PF10186 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.24412 BP_3 198.87 0.76 12829 642926088 XP_008194761.1 1377 1.8e-148 PREDICTED: uncharacterized protein LOC103313398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 153 6.2e-08 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF01222//PF06957//PF15220//PF02990 Ergosterol biosynthesis ERG4/ERG24 family//Coatomer (COPI) alpha subunit C-terminus//Hypoxia-inducible lipid droplet-associated//Endomembrane protein 70 GO:0016192//GO:0006886//GO:0008284//GO:0001819//GO:0010884 vesicle-mediated transport//intracellular protein transport//positive regulation of cell proliferation//positive regulation of cytokine production//positive regulation of lipid storage GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0016021//GO:0030126//GO:0016020 integral component of membrane//COPI vesicle coat//membrane -- -- Cluster-8309.24414 BP_3 145.00 5.33 1604 189235800 XP_001808901.1 1195 2.8e-128 PREDICTED: RNA-binding protein 40 [Tribolium castaneum]>gi|270004699|gb|EFA01147.1| hypothetical protein TcasGA2_TC010372 [Tribolium castaneum] -- -- -- -- -- K13157 RNPC3 U11/U12 small nuclear ribonucleoprotein 65 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13157 Q3UZ01 593 7.4e-60 RNA-binding protein 40 OS=Mus musculus GN=Rnpc3 PE=2 SV=2 PF00076//PF02205 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//WH2 motif -- -- GO:0003779//GO:0003676 actin binding//nucleic acid binding -- -- KOG4206 Spliceosomal protein snRNP-U1A/U2B Cluster-8309.24416 BP_3 59.10 0.69 4399 270013788 EFA10236.1 2986 0.0e+00 hypothetical protein TcasGA2_TC012433 [Tribolium castaneum] -- -- -- -- -- K08333 PIK3R4, VPS15 phosphoinositide-3-kinase, regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08333 Q8VD65 1270 6.4e-138 Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus GN=Pik3r4 PE=1 SV=3 PF07714//PF00400//PF00069//PF02985 Protein tyrosine kinase//WD domain, G-beta repeat//Protein kinase domain//HEAT repeat GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG1240 Protein kinase containing WD40 repeats Cluster-8309.24417 BP_3 168.09 2.00 4335 91090274 XP_970683.1 4971 0.0e+00 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08333 PIK3R4, VPS15 phosphoinositide-3-kinase, regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08333 Q8VD65 1913 1.7e-212 Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus GN=Pik3r4 PE=1 SV=3 PF07714//PF00400//PF02985//PF00069 Protein tyrosine kinase//WD domain, G-beta repeat//HEAT repeat//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- KOG1240 Protein kinase containing WD40 repeats Cluster-8309.24418 BP_3 91.00 3.68 1483 688607278 XP_009294113.1 340 3.6e-29 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 721 [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 O88553 330 2.1e-29 Zinc finger protein 37 OS=Rattus norvegicus GN=Zfp37 PE=2 SV=1 PF13465//PF00096//PF04218//PF13912//PF07776//PF00320 Zinc-finger double domain//Zinc finger, C2H2 type//CENP-B N-terminal DNA-binding domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0046872//GO:0008270//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//metal ion binding//zinc ion binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.24420 BP_3 14.01 0.52 1595 546673008 ERL84694.1 371 9.9e-33 hypothetical protein D910_02120 [Dendroctonus ponderosae] 533163901 XM_005395664.1 81 6.7094e-32 PREDICTED: Chinchilla lanigera actin related protein 2/3 complex, subunit 2, 34kDa (Arpc2), transcript variant X3, mRNA K05758 ARPC2 actin related protein 2/3 complex, subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05758 Q9VIM5 339 2.1e-30 Actin-related protein 2/3 complex subunit 2 OS=Drosophila melanogaster GN=Arpc2 PE=2 SV=2 PF04045 Arp2/3 complex, 34 kD subunit p34-Arc GO:0034314//GO:0030833 Arp2/3 complex-mediated actin nucleation//regulation of actin filament polymerization -- -- GO:0005885//GO:0015629 Arp2/3 protein complex//actin cytoskeleton KOG2826 Actin-related protein Arp2/3 complex, subunit ARPC2 Cluster-8309.24422 BP_3 43.92 1.49 1713 642912091 XP_008200799.1 1091 3.4e-116 PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912093|ref|XP_008200800.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912095|ref|XP_008200802.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24424 BP_3 17.77 0.85 1304 642934311 XP_008198594.1 632 4.4e-63 PREDICTED: E3 ubiquitin-protein ligase MARCH2-like [Tribolium castaneum]>gi|270012899|gb|EFA09347.1| hypothetical protein TcasGA2_TC001673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD3 219 1.4e-16 E3 ubiquitin-protein ligase MARCH3 OS=Homo sapiens GN=MARCH3 PE=2 SV=1 PF12906 RING-variant domain -- -- GO:0008270 zinc ion binding -- -- KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.24425 BP_3 133.23 6.67 1254 642934311 XP_008198594.1 769 5.5e-79 PREDICTED: E3 ubiquitin-protein ligase MARCH2-like [Tribolium castaneum]>gi|270012899|gb|EFA09347.1| hypothetical protein TcasGA2_TC001673 [Tribolium castaneum] -- -- -- -- -- K10658 MARCH3 E3 ubiquitin-protein ligase MARCH3 http://www.genome.jp/dbget-bin/www_bget?ko:K10658 Q86UD3 293 3.6e-25 E3 ubiquitin-protein ligase MARCH3 OS=Homo sapiens GN=MARCH3 PE=2 SV=1 PF00097//PF02511//PF12906//PF01363//PF05495//PF13639 Zinc finger, C3HC4 type (RING finger)//Thymidylate synthase complementing protein//RING-variant domain//FYVE zinc finger//CHY zinc finger//Ring finger domain GO:0006206//GO:0006231 pyrimidine nucleobase metabolic process//dTMP biosynthetic process GO:0050660//GO:0050797//GO:0008270//GO:0005515//GO:0046872 flavin adenine dinucleotide binding//thymidylate synthase (FAD) activity//zinc ion binding//protein binding//metal ion binding -- -- KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.24427 BP_3 458.52 9.52 2614 198475573 XP_002132955.1 673 1.6e-67 GA26108 [Drosophila pseudoobscura pseudoobscura]>gi|198138883|gb|EDY70357.1| GA26108 [Drosophila pseudoobscura pseudoobscura] 194893319 XM_001977817.1 90 1.10138e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- Q8R4Y4 198 7.7e-14 Stabilin-1 OS=Mus musculus GN=Stab1 PE=1 SV=1 PF07527//PF00558//PF00008//PF04882 Hairy Orange//Vpu protein//EGF-like domain//Peroxin-3 GO:0032801//GO:0006812//GO:0006355//GO:0019076//GO:0007031 receptor catabolic process//cation transport//regulation of transcription, DNA-templated//viral release from host cell//peroxisome organization GO:0005261//GO:0005515//GO:0003677 cation channel activity//protein binding//DNA binding GO:0005779//GO:0033644 integral component of peroxisomal membrane//host cell membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.24428 BP_3 6.25 0.63 771 -- -- -- -- -- 642916149 XM_967968.3 68 5.34347e-25 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24430 BP_3 209.00 3.66 3044 -- -- -- -- -- 462464129 APGK01005035.1 75 2.79951e-28 Dendroctonus ponderosae Seq01005037, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24431 BP_3 93.00 13.99 612 478253785 ENN74077.1 553 3.0e-54 hypothetical protein YQE_09050, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0V207 125 5.2e-06 FTS and Hook-interacting protein homolog OS=Danio rerio GN=fam160a2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24435 BP_3 28.21 0.40 3660 546676485 ERL87486.1 295 1.5e-23 hypothetical protein D910_04878 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03213//PF04574 Poxvirus P35 protein//Protein of unknown function (DUF592) GO:0006807//GO:0006355//GO:0006342//GO:0006476 nitrogen compound metabolic process//regulation of transcription, DNA-templated//chromatin silencing//protein deacetylation GO:0008270//GO:0051287//GO:0017136//GO:0016811 zinc ion binding//NAD binding//NAD-dependent histone deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0000118//GO:0019031 histone deacetylase complex//viral envelope -- -- Cluster-8309.24437 BP_3 121.14 1.80 3527 546676485 ERL87486.1 443 9.8e-41 hypothetical protein D910_04878 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03213 Poxvirus P35 protein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.24438 BP_3 138.88 1.98 3674 546676485 ERL87486.1 295 1.5e-23 hypothetical protein D910_04878 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24440 BP_3 78.90 0.80 5037 748995296 AJE75670.1 1570 2.9e-171 putative glycosyl hydrolase [Chrysomela lapponica] 642917249 XM_962192.3 115 2.70386e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1035 1.3e-110 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF13499//PF00506//PF13405//PF10591//PF00232//PF01977//PF00036//PF09398 EF-hand domain pair//Influenza virus nucleoprotein//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//Glycosyl hydrolase family 1//3-octaprenyl-4-hydroxybenzoate carboxy-lyase//EF hand//FOP N terminal dimerisation domain GO:0007165//GO:0034453//GO:0006744//GO:0005975 signal transduction//microtubule anchoring//ubiquinone biosynthetic process//carbohydrate metabolic process GO:0016831//GO:0004553//GO:0005198//GO:0005509 carboxy-lyase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//structural molecule activity//calcium ion binding GO:0005815//GO:0005886//GO:0005578 microtubule organizing center//plasma membrane//proteinaceous extracellular matrix KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.24441 BP_3 68.33 1.82 2102 642917250 XP_967285.3 1439 1.9e-156 PREDICTED: SPARC-related modular calcium-binding protein 2 isoform X2 [Tribolium castaneum] 642917249 XM_962192.3 115 1.1179e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA -- -- -- -- Q9H4F8 316 1.3e-27 SPARC-related modular calcium-binding protein 1 OS=Homo sapiens GN=SMOC1 PE=1 SV=1 PF04347//PF13499//PF13405//PF10591//PF13202//PF07648//PF00036//PF00050 Flagellar biosynthesis protein, FliO//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//Kazal-type serine protease inhibitor domain//EF hand//Kazal-type serine protease inhibitor domain GO:0007165//GO:0044781 signal transduction//bacterial-type flagellum organization GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016021//GO:0005578 integral component of membrane//proteinaceous extracellular matrix KOG4578 Uncharacterized conserved protein, contains KAZAL and TY domains Cluster-8309.24442 BP_3 10.00 0.43 1411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24443 BP_3 5827.91 122.97 2576 642919719 XP_008192036.1 1193 7.7e-128 PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919721|ref|XP_008192037.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919723|ref|XP_008192039.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|270005423|gb|EFA01871.1| hypothetical protein TcasGA2_TC007476 [Tribolium castaneum] -- -- -- -- -- K17479 GRXCR1 glutaredoxin domain-containing cysteine-rich protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17479 Q9VNL4 798 2.0e-83 Glutaredoxin domain-containing cysteine-rich protein CG31559 OS=Drosophila melanogaster GN=CG31559 PE=1 SV=2 PF00684//PF00462//PF03334 DnaJ central domain//Glutaredoxin//Na+/H+ antiporter subunit GO:0015672//GO:0015992//GO:0045454//GO:0006118 monovalent inorganic cation transport//proton transport//cell redox homeostasis//obsolete electron transport GO:0031072//GO:0051082//GO:0009055//GO:0005451//GO:0015035 heat shock protein binding//unfolded protein binding//electron carrier activity//monovalent cation:proton antiporter activity//protein disulfide oxidoreductase activity -- -- KOG2824 Glutaredoxin-related protein Cluster-8309.24444 BP_3 8.00 0.61 924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24445 BP_3 108.16 8.51 904 153792270 NP_001093280.1 350 1.5e-30 malate dehydrogenase [Bombyx mori]>gi|95103050|gb|ABF51466.1| malate dehydrogenase [Bombyx mori] -- -- -- -- -- K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P78715 165 1.8e-10 Malic enzyme, hydrogenosomal OS=Neocallimastix frontalis PE=1 SV=1 -- -- GO:0044710//GO:0006099//GO:0006108 single-organism metabolic process//tricarboxylic acid cycle//malate metabolic process GO:0004470//GO:0000166//GO:0016616 malic enzyme activity//nucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.24447 BP_3 64.04 0.82 4078 478254666 ENN74907.1 2515 6.2e-281 hypothetical protein YQE_08485, partial [Dendroctonus ponderosae] -- -- -- -- -- K18085 MTMR10_11_12 myotubularin-related protein 10/11/12 http://www.genome.jp/dbget-bin/www_bget?ko:K18085 Q6NU08 902 2.8e-95 Myotubularin-related protein 10-B OS=Xenopus laevis GN=mtmr10-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.2445 BP_3 10.00 0.51 1241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24450 BP_3 159.32 1.98 4176 642931762 XP_008196718.1 2808 0.0e+00 PREDICTED: exocyst complex component 7 [Tribolium castaneum]>gi|270011742|gb|EFA08190.1| hypothetical protein TcasGA2_TC005817 [Tribolium castaneum] -- -- -- -- -- K07195 EXOC7, EXO70 exocyst complex component 7 http://www.genome.jp/dbget-bin/www_bget?ko:K07195 Q9VSJ8 1391 5.6e-152 Exocyst complex component 7 OS=Drosophila melanogaster GN=exo70 PE=1 SV=2 PF00700//PF10392//PF02214//PF03081 Bacterial flagellin C-terminal helical region//Golgi transport complex subunit 5//BTB/POZ domain//Exo70 exocyst complex subunit GO:0006891//GO:0006887//GO:0051260//GO:0071973 intra-Golgi vesicle-mediated transport//exocytosis//protein homooligomerization//bacterial-type flagellum-dependent cell motility GO:0005198 structural molecule activity GO:0000145//GO:0017119 exocyst//Golgi transport complex KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes Cluster-8309.24451 BP_3 1.92 0.35 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24453 BP_3 9.14 0.48 1207 642910991 XP_008193498.1 428 1.8e-39 PREDICTED: FUN14 domain-containing protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17986 FUNDC1 FUN14 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17986 Q4RY26 186 8.7e-13 FUN14 domain-containing protein 1 OS=Tetraodon nigroviridis GN=fundc1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4099 Predicted membrane protein Cluster-8309.24458 BP_3 743.33 7.87 4845 546675277 ERL86513.1 2764 9.9e-310 hypothetical protein D910_03917 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PD19 1667 6.5e-184 UPF0668 protein C10orf76 homolog OS=Mus musculus PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG4654 Uncharacterized conserved protein Cluster-8309.24460 BP_3 101.37 2.85 2008 546683711 ERL93489.1 1520 7.3e-166 hypothetical protein D910_10779 [Dendroctonus ponderosae] -- -- -- -- -- K11314 TADA2A, ADA2 transcriptional adapter 2-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11314 Q6AYE3 647 5.1e-66 Transcriptional adapter 2-alpha OS=Rattus norvegicus GN=Tada2a PE=2 SV=1 PF04433//PF00643 SWIRM domain//B-box zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005622 intracellular KOG0457 Histone acetyltransferase complex SAGA/ADA, subunit ADA2 Cluster-8309.24463 BP_3 19.00 1.29 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24464 BP_3 9.00 1.63 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24465 BP_3 20.00 1.63 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24466 BP_3 308.25 12.07 1523 642926165 XP_008194811.1 1671 1.7e-183 PREDICTED: vinculin isoform X1 [Tribolium castaneum] -- -- -- -- -- K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 960 2.0e-102 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF01442//PF06009 Vinculin family//Apolipoprotein A1/A4/E domain//Laminin Domain II GO:0042157//GO:0007155//GO:0006869 lipoprotein metabolic process//cell adhesion//lipid transport GO:0051015//GO:0008289 actin filament binding//lipid binding GO:0005576 extracellular region KOG3681 Alpha-catenin Cluster-8309.24468 BP_3 28.11 0.83 1929 478252186 ENN72614.1 316 2.9e-26 hypothetical protein YQE_10713, partial [Dendroctonus ponderosae]>gi|546673125|gb|ERL84790.1| hypothetical protein D910_02215 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03188//PF07690//PF00033//PF01292//PF02038 Eukaryotic cytochrome b561//Major Facilitator Superfamily//Cytochrome b/b6/petB//Prokaryotic cytochrome b561//ATP1G1/PLM/MAT8 family GO:0006118//GO:0006811//GO:0055085//GO:0022904 obsolete electron transport//ion transport//transmembrane transport//respiratory electron transport chain GO:0009055//GO:0005216 electron carrier activity//ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.24469 BP_3 1465.89 49.19 1728 642914239 XP_008201604.1 450 7.4e-42 PREDICTED: cytochrome b561 domain-containing protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E965 167 2.0e-10 Cytochrome b561 domain-containing protein 2 OS=Bos taurus GN=CYB561D2 PE=2 SV=1 PF07690//PF03188//PF00672//PF02038 Major Facilitator Superfamily//Eukaryotic cytochrome b561//HAMP domain//ATP1G1/PLM/MAT8 family GO:0006811//GO:0007165//GO:0055085 ion transport//signal transduction//transmembrane transport GO:0005216//GO:0004871 ion channel activity//signal transducer activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.24470 BP_3 50.62 1.44 1984 478252210 ENN72638.1 1453 4.2e-158 hypothetical protein YQE_10736, partial [Dendroctonus ponderosae] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 Q9VPH2 968 3.0e-103 DNA primase large subunit OS=Drosophila melanogaster GN=DNApol-alpha60 PE=1 SV=2 PF00542//PF04104 Ribosomal protein L7/L12 C-terminal domain//Eukaryotic and archaeal DNA primase, large subunit GO:0042254//GO:0006269//GO:0006412//GO:0006351 ribosome biogenesis//DNA replication, synthesis of RNA primer//translation//transcription, DNA-templated GO:0003735//GO:0003896 structural constituent of ribosome//DNA primase activity GO:0005730//GO:0005840//GO:0005657 nucleolus//ribosome//replication fork KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.24475 BP_3 1788.73 23.18 4011 270297184 NP_001161900.1 704 6.1e-71 cuticular protein analogous to peritrophins 1-I precursor [Tribolium castaneum]>gi|268373732|gb|ACZ04319.1| CPAP1-I [Tribolium castaneum]>gi|270014341|gb|EFA10789.1| hypothetical protein TcasGA2_TC012766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05412 Equine arterivirus Nsp2-type cysteine proteinase GO:0016032//GO:0019082 viral process//viral protein processing -- -- -- -- -- -- Cluster-8309.24477 BP_3 10.72 0.38 1640 91078236 XP_966494.1 602 1.7e-59 PREDICTED: ras-related protein Rab-21 [Tribolium castaneum]>gi|270003941|gb|EFA00389.1| hypothetical protein TcasGA2_TC003235 [Tribolium castaneum] -- -- -- -- -- K07890 RAB21 Ras-related protein Rab-21 http://www.genome.jp/dbget-bin/www_bget?ko:K07890 P55745 569 4.6e-57 Ras-related protein Rab-21 OS=Canis familiaris GN=RAB21 PE=3 SV=3 PF08477//PF01926//PF00071//PF00025//PF04670 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region GO:0015031//GO:0007264 protein transport//small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.24478 BP_3 114.49 3.35 1937 91088681 XP_974930.1 1028 7.9e-109 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JFV8 482 6.7e-47 Synaptic vesicle membrane protein VAT-1 homolog OS=Danio rerio GN=vat1 PE=2 SV=1 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0005488 binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.24479 BP_3 20.10 0.58 1958 270006914 EFA03362.1 1138 1.4e-121 hypothetical protein TcasGA2_TC013347 [Tribolium castaneum] -- -- -- -- -- K10846 ERCC5, XPG, RAD2 DNA excision repair protein ERCC-5 http://www.genome.jp/dbget-bin/www_bget?ko:K10846 P14629 534 6.3e-53 DNA repair protein complementing XP-G cells homolog OS=Xenopus laevis GN=ercc5 PE=2 SV=1 PF00752 XPG N-terminal domain GO:0006281 DNA repair GO:0004518 nuclease activity -- -- KOG2520 5'-3' exonuclease Cluster-8309.2448 BP_3 8.00 0.52 1033 270004778 EFA01226.1 194 2.1e-12 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24480 BP_3 8.98 1.04 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24481 BP_3 57.66 1.81 1826 642926262 XP_001813701.2 686 3.4e-69 PREDICTED: E3 ubiquitin-protein ligase FANCL-like [Tribolium castaneum] -- -- -- -- -- K10606 FANCL, PHF9 E3 ubiquitin-protein ligase FANCL http://www.genome.jp/dbget-bin/www_bget?ko:K10606 Q9CR14 295 3.0e-25 E3 ubiquitin-protein ligase FANCL OS=Mus musculus GN=Fancl PE=1 SV=1 PF00628//PF13639//PF00130 PHD-finger//Ring finger domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.24482 BP_3 860.45 9.02 4888 91094031 XP_967783.1 1988 9.6e-220 PREDICTED: protein germ cell-less [Tribolium castaneum]>gi|270004797|gb|EFA01245.1| germ cell-less [Tribolium castaneum] -- -- -- -- -- K10485 BTBD13, GMCL1, GCL BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1) http://www.genome.jp/dbget-bin/www_bget?ko:K10485 Q01820 1009 1.3e-107 Protein germ cell-less OS=Drosophila melanogaster GN=gcl PE=2 SV=1 PF00651//PF02096 BTB/POZ domain//60Kd inner membrane protein GO:0051205 protein insertion into membrane GO:0005515 protein binding GO:0016021 integral component of membrane KOG1239 Inner membrane protein translocase involved in respiratory chain assembly Cluster-8309.24483 BP_3 1682.25 24.53 3597 270002066 EEZ98513.1 3770 0.0e+00 hypothetical protein TcasGA2_TC001014 [Tribolium castaneum] -- -- -- -- -- K08626 ADAMTS12 a disintegrin and metalloproteinase with thrombospondin motifs 12 http://www.genome.jp/dbget-bin/www_bget?ko:K08626 Q9UKP4 1763 3.6e-195 A disintegrin and metalloproteinase with thrombospondin motifs 7 OS=Homo sapiens GN=ADAMTS7 PE=1 SV=2 PF10462//PF00413//PF05986//PF01562//PF01421 Peptidase M66//Matrixin//ADAM-TS Spacer 1//Reprolysin family propeptide//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.24485 BP_3 1.00 29.81 217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24486 BP_3 245.39 2.33 5366 91077932 XP_974190.1 2678 1.0e-299 PREDICTED: conserved oligomeric Golgi complex subunit 7 [Tribolium castaneum] 820862785 XM_003697932.2 121 1.33129e-53 PREDICTED: Apis florea U4/U6 small nuclear ribonucleoprotein Prp4 (LOC100870360), mRNA K12662 PRPF4, PRP4 U4/U6 small nuclear ribonucleoprotein PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K12662 Q3MHE2 1614 1.0e-177 U4/U6 small nuclear ribonucleoprotein Prp4 OS=Bos taurus GN=PRPF4 PE=2 SV=1 PF10191//PF10392//PF00400//PF02468 Golgi complex component 7 (COG7)//Golgi transport complex subunit 5//WD domain, G-beta repeat//Photosystem II reaction centre N protein (psbN) GO:0006891//GO:0015979//GO:0006886 intra-Golgi vesicle-mediated transport//photosynthesis//intracellular protein transport GO:0005515 protein binding GO:0016020//GO:0017119//GO:0009523//GO:0009539 membrane//Golgi transport complex//photosystem II//photosystem II reaction center KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats) Cluster-8309.24488 BP_3 99.04 1.20 4282 189238033 XP_966902.2 1468 1.7e-159 PREDICTED: transmembrane protein 185A [Tribolium castaneum]>gi|270008773|gb|EFA05221.1| hypothetical protein TcasGA2_TC015362 [Tribolium castaneum] 642925153 XM_961809.3 242 5.78091e-121 PREDICTED: Tribolium castaneum transmembrane protein 185A (LOC655280), mRNA -- -- -- -- Q8R3R5 844 1.6e-88 Transmembrane protein 185B OS=Mus musculus GN=Tmem185b PE=2 SV=1 PF02535//PF15048//PF01757//PF00892 ZIP Zinc transporter//Organic solute transporter subunit beta protein//Acyltransferase family//EamA-like transporter family GO:0006810//GO:0015721//GO:0030001//GO:0055085 transport//bile acid and bile salt transport//metal ion transport//transmembrane transport GO:0005215//GO:0046982//GO:0016747//GO:0046873 transporter activity//protein heterodimerization activity//transferase activity, transferring acyl groups other than amino-acyl groups//metal ion transmembrane transporter activity GO:0016021//GO:0005886//GO:0016020 integral component of membrane//plasma membrane//membrane KOG3907 ZIP-like zinc transporter proteins Cluster-8309.24494 BP_3 46.26 0.66 3691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00839 Cysteine rich repeat -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.24495 BP_3 13.00 1.11 858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24496 BP_3 4.00 0.75 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24497 BP_3 222.00 6.11 2042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24501 BP_3 98.00 7.62 912 270015247 EFA11695.1 556 2.0e-54 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24502 BP_3 3.00 1.12 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24503 BP_3 86.15 1.73 2689 642939351 XP_008197109.1 760 1.3e-77 PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum]>gi|642939353|ref|XP_008197119.1| PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24504 BP_3 57.75 0.34 8377 642916033 XP_008190864.1 1601 1.2e-174 PREDICTED: lisH domain and HEAT repeat-containing protein KIAA1468 homolog [Tribolium castaneum]>gi|270003733|gb|EFA00181.1| hypothetical protein TcasGA2_TC003006 [Tribolium castaneum] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q6P6Y1 477 1.1e-45 LisH domain and HEAT repeat-containing protein KIAA1468 homolog OS=Danio rerio GN=zgc:66014 PE=2 SV=1 PF03721//PF00056//PF01266//PF07992//PF02985//PF01494//PF06156 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//lactate/malate dehydrogenase, NAD binding domain//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//HEAT repeat//FAD binding domain//Protein of unknown function (DUF972) GO:0006260//GO:0055114 DNA replication//oxidation-reduction process GO:0071949//GO:0016616//GO:0051287//GO:0005515//GO:0016491 FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//protein binding//oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.24505 BP_3 179.04 5.58 1837 642937544 XP_008199089.1 1005 3.5e-106 PREDICTED: major facilitator superfamily domain-containing protein 9-like isoform X2 [Tribolium castaneum]>gi|270001229|gb|EEZ97676.1| hypothetical protein TcasGA2_TC016221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0T7 460 2.2e-44 Major facilitator superfamily domain-containing protein 9 OS=Mus musculus GN=Mfsd9 PE=2 SV=1 PF00083//PF05121//PF07690 Sugar (and other) transporter//Gas vesicle protein K//Major Facilitator Superfamily GO:0031412//GO:0055085 gas vesicle organization//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.24508 BP_3 619.36 11.73 2837 642927089 XP_008195133.1 2938 0.0e+00 PREDICTED: rhophilin-2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TNR1 1241 9.5e-135 Rhophilin-2 OS=Danio rerio GN=rhpn2 PE=2 SV=1 PF13180//PF02185//PF00595 PDZ domain//Hr1 repeat//PDZ domain (Also known as DHR or GLGF) GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2220 Predicted signal transduction protein Cluster-8309.24509 BP_3 515.45 14.40 2017 642929605 XP_008195901.1 899 7.5e-94 PREDICTED: polyadenylate-binding protein 2 isoform X1 [Tribolium castaneum]>gi|270010566|gb|EFA07014.1| hypothetical protein TcasGA2_TC009984 [Tribolium castaneum] 196012775 XM_002116214.1 70 1.11053e-25 Trichoplax adhaerens hypothetical protein, mRNA K14396 PABPN1, PABP2 polyadenylate-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14396 Q28ZX3 645 8.7e-66 Polyadenylate-binding protein 2 OS=Drosophila pseudoobscura pseudoobscura GN=Pabp2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.2451 BP_3 161.81 10.25 1053 675380956 KFM73858.1 178 1.6e-10 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24510 BP_3 210.93 7.84 1588 189239479 XP_975440.2 899 5.9e-94 PREDICTED: polyadenylate-binding protein 2 isoform X2 [Tribolium castaneum] 196012775 XM_002116214.1 70 8.70155e-26 Trichoplax adhaerens hypothetical protein, mRNA K14396 PABPN1, PABP2 polyadenylate-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14396 Q28ZX3 645 6.8e-66 Polyadenylate-binding protein 2 OS=Drosophila pseudoobscura pseudoobscura GN=Pabp2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.24511 BP_3 54.65 0.91 3182 91080725 XP_975392.1 1688 3.8e-185 PREDICTED: arginine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270005463|gb|EFA01911.1| hypothetical protein TcasGA2_TC007521 [Tribolium castaneum] 306980173 CP002198.1 65 1.06055e-22 Cyanothece sp. PCC 7822, complete genome K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 A7YW98 1354 8.4e-148 Arginine--tRNA ligase, cytoplasmic OS=Bos taurus GN=RARS PE=2 SV=1 PF00133//PF09334//PF03485//PF00750//PF07062//PF05746 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Arginyl tRNA synthetase N terminal domain//tRNA synthetases class I (R)//Clc-like//DALR anticodon binding domain GO:0006525//GO:0006560//GO:0006420//GO:0006418 arginine metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0005524//GO:0004814//GO:0000166//GO:0004812 ATP binding//arginine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG4426 Arginyl-tRNA synthetase Cluster-8309.24514 BP_3 1840.88 46.77 2189 642923298 XP_008193694.1 1320 1.2e-142 PREDICTED: presenilins-associated rhomboid-like protein, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 B0BNE5 821 3.7e-86 S-formylglutathione hydrolase OS=Rattus norvegicus GN=Esd PE=2 SV=1 PF07224//PF07578//PF00326//PF07819//PF10503//PF01764//PF04612//PF12740//PF01694 Chlorophyllase//Lipid A Biosynthesis N-terminal domain//Prolyl oligopeptidase family//PGAP1-like protein//Esterase PHB depolymerase//Lipase (class 3)//Type II secretion system (T2SS), protein M//Chlorophyllase enzyme//Rhomboid family GO:0006508//GO:0006858//GO:0006505//GO:0009245//GO:0015996//GO:0015994//GO:0006886//GO:0006629 proteolysis//extracellular transport//GPI anchor metabolic process//lipid A biosynthetic process//chlorophyll catabolic process//chlorophyll metabolic process//intracellular protein transport//lipid metabolic process GO:0008236//GO:0008915//GO:0004252//GO:0016788//GO:0047746 serine-type peptidase activity//lipid-A-disaccharide synthase activity//serine-type endopeptidase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3101 Esterase D Cluster-8309.24515 BP_3 144.47 1.52 4860 478251097 ENN71573.1 1384 1.0e-149 hypothetical protein YQE_11673, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9WU40 209 7.6e-15 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.24516 BP_3 55.38 0.60 4732 642937864 XP_008200330.1 1951 1.8e-215 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVG3 1152 3.3e-124 Protein FAM91A1 OS=Mus musculus GN=Fam91a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.24517 BP_3 1502.92 41.89 2021 91089077 XP_971296.1 743 9.2e-76 PREDICTED: density-regulated protein [Tribolium castaneum]>gi|270012410|gb|EFA08858.1| hypothetical protein TcasGA2_TC006559 [Tribolium castaneum] 389609388 AK401684.1 173 6.15205e-83 Papilio xuthus mRNA for similar to CG9099, complete cds, sequence id: Px-1124 -- -- -- -- Q9VX98 667 2.5e-68 Density-regulated protein homolog OS=Drosophila melanogaster GN=DENR PE=1 SV=3 PF01253 Translation initiation factor SUI1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG3239 Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.24518 BP_3 54.44 0.87 3320 612342210 AHW99830.1 4282 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] -- -- -- -- -- K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 3114 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.24519 BP_3 51.43 0.75 3598 478262642 ENN81206.1 536 1.6e-51 hypothetical protein YQE_02396, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V7Q6 307 2.4e-26 Serine/threonine-protein kinase ULK3 OS=Xenopus laevis GN=ulk3 PE=2 SV=1 PF02740//PF00069//PF06293//PF03829//PF09268//PF07714//PF05445 Colipase, C-terminal domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PTS system glucitol/sorbitol-specific IIA component//Clathrin, heavy-chain linker//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0009401//GO:0006468//GO:0006886//GO:0016192//GO:0007586//GO:0008643//GO:0016042 phosphoenolpyruvate-dependent sugar phosphotransferase system//protein phosphorylation//intracellular protein transport//vesicle-mediated transport//digestion//carbohydrate transport//lipid catabolic process GO:0005198//GO:0005524//GO:0004672//GO:0008047//GO:0016773//GO:0008982 structural molecule activity//ATP binding//protein kinase activity//enzyme activator activity//phosphotransferase activity, alcohol group as acceptor//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0005737//GO:0030130//GO:0009357//GO:0030132//GO:0005576//GO:0016020 cytoplasm//clathrin coat of trans-Golgi network vesicle//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//clathrin coat of coated pit//extracellular region//membrane -- -- Cluster-8309.2452 BP_3 14.54 0.60 1469 675380956 KFM73858.1 178 2.2e-10 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24521 BP_3 57.92 0.59 4993 642927107 XP_008195140.1 5178 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Tribolium castaneum] 642927106 XM_008196918.1 219 4.11969e-108 PREDICTED: Tribolium castaneum sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (LOC660611), mRNA -- -- -- -- Q22328 693 5.9e-71 Protein lev-9 OS=Caenorhabditis elegans GN=lev-9 PE=1 SV=3 PF02793//PF00095 Hormone receptor domain//WAP-type (Whey Acidic Protein) 'four-disulfide core' GO:0007186 G-protein coupled receptor signaling pathway GO:0030414//GO:0004930 peptidase inhibitor activity//G-protein coupled receptor activity GO:0005576//GO:0016020 extracellular region//membrane KOG4297 C-type lectin Cluster-8309.24522 BP_3 24.00 0.81 1728 625256567 XP_007619640.1 546 5.5e-53 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like, partial [Cricetulus griseus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q61116 513 1.5e-50 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF00096//PF13465//PF07649//PF13912//PF02892//PF04810 Zinc finger, C2H2 type//Zinc-finger double domain//C1-like domain//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888//GO:0055114 intracellular protein transport//ER to Golgi vesicle-mediated transport//oxidation-reduction process GO:0003677//GO:0046872//GO:0047134//GO:0008270 DNA binding//metal ion binding//protein-disulfide reductase activity//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.24523 BP_3 658.00 9.59 3600 850315944 XP_012863126.1 259 2.2e-19 PREDICTED: zinc finger protein 709-like [Echinops telfairi] -- -- -- -- -- K04462 EVI1 ecotropic virus integration site 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04462 A2T812 249 1.3e-19 Zinc finger protein 287 OS=Pongo pygmaeus GN=ZNF287 PE=3 SV=1 PF02892//PF13912//PF01428//PF16622//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.24524 BP_3 718.96 3.79 9447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12297//PF16276 Ellis van Creveld protein 2 like protein//Nucleophosmin C-terminal domain GO:0007224 smoothened signaling pathway GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.24525 BP_3 934.41 4.94 9400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16276//PF12297 Nucleophosmin C-terminal domain//Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.24528 BP_3 706.01 3.37 10383 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.6e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF01155//PF00632//PF02891//PF00397//PF00168//PF05430 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//HECT-domain (ubiquitin-transferase)//MIZ/SP-RING zinc finger//WW domain//C2 domain//S-adenosyl-L-methionine-dependent methyltransferase GO:0055114//GO:0006464//GO:0016567 oxidation-reduction process//cellular protein modification process//protein ubiquitination GO:0008270//GO:0016645//GO:0016151//GO:0004842//GO:0005515 zinc ion binding//oxidoreductase activity, acting on the CH-NH group of donors//nickel cation binding//ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.24530 BP_3 414.45 1.71 11958 189235646 XP_968349.2 3078 0.0e+00 PREDICTED: peripheral plasma membrane protein CASK isoform X4 [Tribolium castaneum] 642917490 XM_963256.3 740 0 PREDICTED: Tribolium castaneum peripheral plasma membrane protein CASK (LOC656749), transcript variant X4, mRNA K06103 CASK calcium/calmodulin-dependent serine protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06103 Q24210 2193 1.6e-244 Peripheral plasma membrane protein CASK OS=Drosophila melanogaster GN=CASK PE=1 SV=4 PF13180//PF00018//PF14604//PF01003//PF00570//PF07714//PF00069//PF00595//PF01502 PDZ domain//SH3 domain//Variant SH3 domain//Flavivirus capsid protein C//HRDC domain//Protein tyrosine kinase//Protein kinase domain//PDZ domain (Also known as DHR or GLGF)//Phosphoribosyl-AMP cyclohydrolase GO:0006468//GO:0000105//GO:0006547 protein phosphorylation//histidine biosynthetic process//histidine metabolic process GO:0005198//GO:0005515//GO:0005524//GO:0004672//GO:0004635//GO:0003676 structural molecule activity//protein binding//ATP binding//protein kinase activity//phosphoribosyl-AMP cyclohydrolase activity//nucleic acid binding GO:0019028//GO:0005622 viral capsid//intracellular KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.24531 BP_3 1.00 0.32 441 642926629 XP_008194947.1 203 8.3e-14 PREDICTED: uncharacterized protein LOC103313441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16497//PF01064 MHC-I family domain//Activin types I and II receptor domain GO:0016310//GO:0009069//GO:0006955//GO:0007178 phosphorylation//serine family amino acid metabolic process//immune response//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.24532 BP_3 483.22 7.62 3348 189242339 XP_967217.2 1417 1.1e-153 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|642939487|ref|XP_008190837.1| PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270016564|gb|EFA13010.1| hypothetical protein TcasGA2_TC001975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 292 1.2e-24 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF01238//PF00560 Leucine rich repeat//Phosphomannose isomerase type I//Leucine Rich Repeat GO:0005975//GO:0006000//GO:0006013 carbohydrate metabolic process//fructose metabolic process//mannose metabolic process GO:0008270//GO:0005515//GO:0004476 zinc ion binding//protein binding//mannose-6-phosphate isomerase activity -- -- -- -- Cluster-8309.24533 BP_3 14.45 2.06 629 642924167 XP_008194036.1 525 5.4e-51 PREDICTED: secernin-3 isoform X1 [Tribolium castaneum]>gi|270007848|gb|EFA04296.1| hypothetical protein TcasGA2_TC014587 [Tribolium castaneum] -- -- -- -- -- K14358 SCRN secernin http://www.genome.jp/dbget-bin/www_bget?ko:K14358 Q803W1 320 1.3e-28 Secernin-3 OS=Danio rerio GN=scrn3 PE=2 SV=1 -- -- GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- -- -- Cluster-8309.24534 BP_3 1722.55 39.87 2374 642924167 XP_008194036.1 1755 4.8e-193 PREDICTED: secernin-3 isoform X1 [Tribolium castaneum]>gi|270007848|gb|EFA04296.1| hypothetical protein TcasGA2_TC014587 [Tribolium castaneum] -- -- -- -- -- K14358 SCRN secernin http://www.genome.jp/dbget-bin/www_bget?ko:K14358 Q803W1 906 5.6e-96 Secernin-3 OS=Danio rerio GN=scrn3 PE=2 SV=1 PF03577 Peptidase family C69 GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- -- -- Cluster-8309.24536 BP_3 228.02 2.24 5207 189237519 XP_973030.2 3459 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.1e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF03470//PF01667//PF13465 XS zinc finger domain//Ribosomal protein S27//Zinc-finger double domain GO:0031047//GO:0006412//GO:0042254 gene silencing by RNA//translation//ribosome biogenesis GO:0003735//GO:0046872 structural constituent of ribosome//metal ion binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.24538 BP_3 674.21 13.31 2733 270004255 EFA00703.1 1234 1.4e-132 hypothetical protein TcasGA2_TC003582 [Tribolium castaneum] 746868949 XM_011067317.1 84 2.49237e-33 PREDICTED: Acromyrmex echinatior IWS1-like protein (LOC105152830), mRNA K17498 SPN1, IWS1 transcription factor SPN1 http://www.genome.jp/dbget-bin/www_bget?ko:K17498 Q3SWT4 759 7.1e-79 Protein IWS1 homolog OS=Rattus norvegicus GN=Iws1 PE=2 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG1793 Uncharacterized conserved protein Cluster-8309.24539 BP_3 369.20 8.95 2280 642916576 XP_969029.3 1234 1.2e-132 PREDICTED: protein IWS1 homolog isoform X1 [Tribolium castaneum] 746868949 XM_011067317.1 84 2.07532e-33 PREDICTED: Acromyrmex echinatior IWS1-like protein (LOC105152830), mRNA K17498 SPN1, IWS1 transcription factor SPN1 http://www.genome.jp/dbget-bin/www_bget?ko:K17498 Q3SWT4 759 5.9e-79 Protein IWS1 homolog OS=Rattus norvegicus GN=Iws1 PE=2 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG1793 Uncharacterized conserved protein Cluster-8309.24541 BP_3 28.91 0.55 2807 270004255 EFA00703.1 1059 2.9e-112 hypothetical protein TcasGA2_TC003582 [Tribolium castaneum] 746868949 XM_011067317.1 84 2.56076e-33 PREDICTED: Acromyrmex echinatior IWS1-like protein (LOC105152830), mRNA K17498 SPN1, IWS1 transcription factor SPN1 http://www.genome.jp/dbget-bin/www_bget?ko:K17498 Q96ST2 666 4.4e-68 Protein IWS1 homolog OS=Homo sapiens GN=IWS1 PE=1 SV=2 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG1793 Uncharacterized conserved protein Cluster-8309.24542 BP_3 9.00 0.91 766 817061123 XP_012252151.1 314 1.9e-26 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17047//PF01673 Synaptotagmin-like mitochondrial-lipid-binding domain//Herpesvirus putative major envelope glycoprotein -- -- GO:0008289 lipid binding GO:0019031 viral envelope -- -- Cluster-8309.24547 BP_3 18.00 1.41 905 344250492 EGW06596.1 1125 2.1e-120 Elongation factor 1-alpha 1 [Cricetulus griseus] 767942081 XM_011535514.1 905 0 PREDICTED: Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), transcript variant X1, mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P17507 855 1.7e-90 Elongation factor 1-alpha, oocyte form OS=Xenopus laevis GN=eef1ao PE=1 SV=1 PF02774//PF03144 Semialdehyde dehydrogenase, dimerisation domain//Elongation factor Tu domain 2 GO:0055114//GO:0008652//GO:0000051 oxidation-reduction process//cellular amino acid biosynthetic process//obsolete urea cycle intermediate metabolic process GO:0016620//GO:0005525//GO:0003942//GO:0046983 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//GTP binding//N-acetyl-gamma-glutamyl-phosphate reductase activity//protein dimerization activity GO:0005737 cytoplasm -- -- Cluster-8309.24549 BP_3 447.45 2.12 10466 642910592 XP_008200017.1 2262 3.5e-251 PREDICTED: uncharacterized protein LOC103314818 isoform X2 [Tribolium castaneum] 642910591 XM_008201795.1 107 1.57837e-45 PREDICTED: Tribolium castaneum uncharacterized LOC103314818 (LOC103314818), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07359//PF08272 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)//Topoisomerase I zinc-ribbon-like GO:0042742//GO:0006265 defense response to bacterium//DNA topological change GO:0003918//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding GO:0005694 chromosome -- -- Cluster-8309.24550 BP_3 11429.29 81.43 7057 332376376 AEE63328.1 726 3.0e-73 unknown [Dendroctonus ponderosae]>gi|546675031|gb|ERL86292.1| hypothetical protein D910_03700 [Dendroctonus ponderosae] -- -- -- -- -- K01493 comEB dCMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01493 P32321 580 1.0e-57 Deoxycytidylate deaminase OS=Homo sapiens GN=DCTD PE=1 SV=2 PF04934//PF09726//PF03261//PF00383 MED6 mediator sub complex component//Transmembrane protein//Cyclin-dependent kinase 5 activator protein//Cytidine and deoxycytidylate deaminase zinc-binding region GO:0045859//GO:0006357 regulation of protein kinase activity//regulation of transcription from RNA polymerase II promoter GO:0016534//GO:0001104//GO:0008270 cyclin-dependent protein kinase 5 activator activity//RNA polymerase II transcription cofactor activity//zinc ion binding GO:0016533//GO:0016021//GO:0016592 cyclin-dependent protein kinase 5 holoenzyme complex//integral component of membrane//mediator complex KOG3127 Deoxycytidylate deaminase Cluster-8309.24552 BP_3 10.00 2.45 488 556774071 XP_005982177.1 160 8.8e-09 PREDICTED: actin, cytoplasmic 1 isoform X1 [Pantholops hodgsonii]>gi|556774073|ref|XP_005982178.1| PREDICTED: actin, cytoplasmic 1 isoform X2 [Pantholops hodgsonii] 164690869 AK309997.1 487 0 Homo sapiens cDNA, FLJ17039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24556 BP_3 7.88 0.34 1424 642912158 XP_008200830.1 1040 2.3e-110 PREDICTED: tRNA pseudouridine synthase A, mitochondrial [Tribolium castaneum] -- -- -- -- -- K06173 truA, PUS1 tRNA pseudouridine38-40 synthase http://www.genome.jp/dbget-bin/www_bget?ko:K06173 Q9Y606 716 3.6e-74 tRNA pseudouridine synthase A, mitochondrial OS=Homo sapiens GN=PUS1 PE=1 SV=3 PF01416 tRNA pseudouridine synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG2553 Pseudouridylate synthase Cluster-8309.24561 BP_3 6.00 0.32 1202 291170322 ADD82417.1 255 2.1e-19 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 119 3.77178e-53 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- PF03278 IpaB/EvcA family GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.24562 BP_3 68.27 1.10 3273 642934081 XP_008196456.1 1036 1.6e-109 PREDICTED: phosphatase and actin regulator 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.5e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00573//PF00344//PF00957 Ribosomal protein L4/L1 family//SecY translocase//Synaptobrevin GO:0016192//GO:0006412//GO:0042254//GO:0015031 vesicle-mediated transport//translation//ribosome biogenesis//protein transport GO:0003735 structural constituent of ribosome GO:0016021//GO:0005840//GO:0016020 integral component of membrane//ribosome//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.24563 BP_3 30.64 1.47 1296 189235436 XP_001812776.1 872 6.5e-91 PREDICTED: protein twisted gastrulation [Tribolium castaneum]>gi|270004290|gb|EFA00738.1| hypothetical protein TcasGA2_TC003620 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54356 495 1.4e-48 Protein twisted gastrulation OS=Drosophila melanogaster GN=tsg PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24564 BP_3 29.65 0.60 2674 728417168 AIY68335.1 1661 4.3e-182 esterase, partial [Leptinotarsa decemlineata] 801385926 XM_012200861.1 84 2.43954e-33 PREDICTED: Atta cephalotes transcription initiation factor IIE subunit beta (LOC105619342), mRNA -- -- -- -- Q8R0W5 391 3.3e-36 Carboxylesterase 4A OS=Mus musculus GN=Ces4a PE=2 SV=2 PF02186//PF02230//PF07859//PF01764 TFIIE beta subunit core domain//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Lipase (class 3) GO:0006629//GO:0006367//GO:0008152 lipid metabolic process//transcription initiation from RNA polymerase II promoter//metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.24565 BP_3 759.64 7.13 5426 91091178 XP_971714.1 2347 2.5e-261 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] 564254995 XM_006266415.1 37 6.67539e-07 PREDICTED: Alligator mississippiensis F-box protein 21 (FBXO21), mRNA K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q63448 1376 4.0e-150 Peroxisomal acyl-coenzyme A oxidase 3 OS=Rattus norvegicus GN=Acox3 PE=1 SV=1 PF12937//PF02770//PF00441//PF00646//PF08755//PF01756 F-box-like//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//F-box domain//Hemimethylated DNA-binding protein YccV like//Acyl-CoA oxidase GO:0055114//GO:0006118//GO:0006631//GO:0006635//GO:0006637 oxidation-reduction process//obsolete electron transport//fatty acid metabolic process//fatty acid beta-oxidation//acyl-CoA metabolic process GO:0016627//GO:0003997//GO:0005515//GO:0003995//GO:0003677 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity//protein binding//acyl-CoA dehydrogenase activity//DNA binding GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.24569 BP_3 194.10 2.02 4926 270004778 EFA01226.1 1385 8.0e-150 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] 5815422 AF177773.1 73 5.88718e-27 Lymantria dispar Lydia retrotransposon, complete sequence -- -- -- -- P04323 1086 1.6e-116 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF04108//PF10044//PF05791//PF06009//PF04750//PF01105//PF08651 Autophagy protein Apg17//Retinal tissue protein//Bacillus haemolytic enterotoxin (HBL)//Laminin Domain II//FAR-17a/AIG1-like protein//emp24/gp25L/p24 family/GOLD//DASH complex subunit Duo1 GO:0006810//GO:0006914//GO:0009405//GO:0006351//GO:0007049//GO:0007155//GO:0007067 transport//autophagy//pathogenesis//transcription, DNA-templated//cell cycle//cell adhesion//mitotic nuclear division -- -- GO:0072686//GO:0016021//GO:0070176//GO:0016020//GO:0042729 mitotic spindle//integral component of membrane//DRM complex//membrane//DASH complex -- -- Cluster-8309.24571 BP_3 225.87 3.20 3697 478255182 ENN75411.1 3024 0.0e+00 hypothetical protein YQE_07962, partial [Dendroctonus ponderosae]>gi|546672240|gb|ERL84192.1| hypothetical protein D910_01568 [Dendroctonus ponderosae]>gi|546682608|gb|ERL92525.1| hypothetical protein D910_09838 [Dendroctonus ponderosae] -- -- -- -- -- K18727 TNPO2 transportin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K18727 Q99LG2 1567 2.0e-172 Transportin-2 OS=Mus musculus GN=Tnpo2 PE=2 SV=1 PF00514//PF07571//PF03810//PF02985 Armadillo/beta-catenin-like repeat//TAF6 C-terminal HEAT repeat domain//Importin-beta N-terminal domain//HEAT repeat GO:0051090//GO:0006886 regulation of sequence-specific DNA binding transcription factor activity//intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding GO:0005634 nucleus KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) Cluster-8309.24572 BP_3 1185.15 29.17 2250 91084649 XP_966904.1 1039 4.9e-110 PREDICTED: spermidine synthase [Tribolium castaneum]>gi|270008634|gb|EFA05082.1| hypothetical protein TcasGA2_TC015179 [Tribolium castaneum] -- -- -- -- -- K00797 speE, SRM spermidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00797 Q64674 898 4.5e-95 Spermidine synthase OS=Mus musculus GN=Srm PE=2 SV=1 -- -- GO:0008152 metabolic process GO:0016740 transferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.24573 BP_3 282.73 10.24 1622 642916569 XP_008191733.1 301 1.3e-24 PREDICTED: uncharacterized protein LOC103312564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24574 BP_3 82.18 2.34 1984 642916569 XP_008191733.1 301 1.6e-24 PREDICTED: uncharacterized protein LOC103312564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24575 BP_3 75.21 1.05 3744 642919756 XP_008192053.1 717 1.8e-72 PREDICTED: ATP-binding cassette sub-family G member 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 235 5.6e-18 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.24578 BP_3 15.84 0.40 2200 642931147 XP_008196461.1 684 6.9e-69 PREDICTED: arginyl-tRNA--protein transferase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K00685 ATE1, ate1 arginine-tRNA-protein transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00685 O96539 546 2.9e-54 Arginyl-tRNA--protein transferase 1 OS=Drosophila melanogaster GN=Ate1 PE=2 SV=3 PF04377 Arginine-tRNA-protein transferase, C terminus GO:0016598 protein arginylation GO:0004057 arginyltransferase activity -- -- KOG1193 Arginyl-tRNA-protein transferase Cluster-8309.2458 BP_3 9.31 0.46 1257 642922567 XP_969703.2 309 1.2e-25 PREDICTED: uncharacterized protein LOC658202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24581 BP_3 50.00 6.19 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24583 BP_3 833.00 33.68 1484 91089517 XP_970614.1 942 5.7e-99 PREDICTED: thioredoxin domain-containing protein 9 [Tribolium castaneum]>gi|270011387|gb|EFA07835.1| hypothetical protein TcasGA2_TC005404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14530 549 8.7e-55 Thioredoxin domain-containing protein 9 OS=Homo sapiens GN=TXNDC9 PE=1 SV=2 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG1672 ATP binding protein Cluster-8309.24585 BP_3 11.62 0.40 1695 844837396 XP_012792468.1 207 1.1e-13 Chromobox protein 8 [Schistosoma haematobium]>gi|685956510|gb|KGB32687.1| Chromobox protein 8 [Schistosoma haematobium] -- -- -- -- -- K11455 CBX8, PC3 chromobox protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11455 Q9HC52 162 7.4e-10 Chromobox protein homolog 8 OS=Homo sapiens GN=CBX8 PE=1 SV=3 PF06524//PF01552 NOA36 protein//Picornavirus 2B protein GO:0006508//GO:0006144//GO:0018144 proteolysis//purine nucleobase metabolic process//RNA-protein covalent cross-linking GO:0016779//GO:0008233//GO:0008270//GO:0008234//GO:0003968//GO:0000166//GO:0005198//GO:0016787//GO:0016740 nucleotidyltransferase activity//peptidase activity//zinc ion binding//cysteine-type peptidase activity//RNA-directed RNA polymerase activity//nucleotide binding//structural molecule activity//hydrolase activity//transferase activity GO:0031379//GO:0005634//GO:0019012 RNA-directed RNA polymerase complex//nucleus//virion KOG2748 Uncharacterized conserved protein, contains chromo domain Cluster-8309.24586 BP_3 18.00 6.47 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03324 Herpesvirus DNA helicase/primase complex associated protein GO:0019079 viral genome replication -- -- -- -- -- -- Cluster-8309.24588 BP_3 773.23 7.03 5596 642933274 XP_008197353.1 2916 0.0e+00 PREDICTED: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 [Tribolium castaneum] 850480667 CP011888.1 37 6.88593e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 1635 3.9e-180 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF01612//PF03798//PF00443//PF09061 3'-5' exonuclease//TLC domain//Ubiquitin carboxyl-terminal hydrolase//Stirrup GO:0016579//GO:0006139 protein deubiquitination//nucleobase-containing compound metabolic process GO:0003676//GO:0008408//GO:0016788//GO:0036459 nucleic acid binding//3'-5' exonuclease activity//hydrolase activity, acting on ester bonds//ubiquitinyl hydrolase activity GO:0016021 integral component of membrane KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.24589 BP_3 91.26 1.27 3762 478251138 ENN71614.1 1171 4.0e-125 hypothetical protein YQE_11713, partial [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q91XA9 609 2.4e-61 Acidic mammalian chitinase OS=Mus musculus GN=Chia PE=1 SV=2 PF00704//PF00839 Glycosyl hydrolases family 18//Cysteine rich repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016020 membrane -- -- Cluster-8309.2459 BP_3 136.36 2.20 3283 91087749 XP_974872.1 354 1.9e-30 PREDICTED: probable H/ACA ribonucleoprotein complex subunit 1 [Tribolium castaneum]>gi|270010737|gb|EFA07185.1| hypothetical protein TcasGA2_TC010191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24591 BP_3 510.49 15.67 1862 91079416 XP_967408.1 1829 1.0e-201 PREDICTED: microspherule protein 1 isoform X1 [Tribolium castaneum]>gi|270004380|gb|EFA00828.1| hypothetical protein TcasGA2_TC003716 [Tribolium castaneum] -- -- -- -- -- K11674 MCRS1, INO80Q microspherule protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11674 Q99L90 1057 1.4e-113 Microspherule protein 1 OS=Mus musculus GN=Mcrs1 PE=1 SV=1 PF00498 FHA domain -- -- GO:0005515 protein binding -- -- KOG2293 Daxx-interacting protein MSP58/p78, contains FHA domain Cluster-8309.24592 BP_3 11.00 1.47 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24595 BP_3 1035.00 73.23 973 91095221 XP_969957.1 950 4.4e-100 PREDICTED: peptidyl-prolyl cis-trans isomerase H [Tribolium castaneum]>gi|270016016|gb|EFA12464.1| hypothetical protein TcasGA2_TC010612 [Tribolium castaneum] 242004769 XM_002423206.1 262 9.75024e-133 Pediculus humanus corporis peptidyl-prolyl cis-trans isomerase H, putative, mRNA K09567 PPIH, CYPH peptidyl-prolyl isomerase H (cyclophilin H) http://www.genome.jp/dbget-bin/www_bget?ko:K09567 O43447 770 1.3e-80 Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens GN=PPIH PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0879 U-snRNP-associated cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.24598 BP_3 38.72 1.26 1775 189238236 XP_972123.2 372 8.4e-33 PREDICTED: guanine nucleotide-binding protein subunit gamma-e [Tribolium castaneum]>gi|270008671|gb|EFA05119.1| hypothetical protein TcasGA2_TC015232 [Tribolium castaneum] 743280388 KM065747.1 140 1.19176e-64 Culex quinquefasciatus clone C2B G-protein gamma-subunit mRNA, complete cds K04547 GNG13 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 http://www.genome.jp/dbget-bin/www_bget?ko:K04547 Q9NFZ3 335 6.8e-30 Guanine nucleotide-binding protein subunit gamma-e OS=Drosophila melanogaster GN=Ggamma30A PE=1 SV=1 PF00631//PF02501 GGL domain//Type II secretion system (T2SS), protein I GO:0015031//GO:0015628//GO:0007186//GO:0007165 protein transport//protein secretion by the type II secretion system//G-protein coupled receptor signaling pathway//signal transduction GO:0008565//GO:0004871 protein transporter activity//signal transducer activity GO:0015627//GO:0005834 type II protein secretion system complex//heterotrimeric G-protein complex KOG4119 G protein gamma subunit Cluster-8309.24603 BP_3 647.80 11.75 2950 91076316 XP_969753.1 1900 9.2e-210 PREDICTED: xylulose kinase [Tribolium castaneum]>gi|270002483|gb|EEZ98930.1| hypothetical protein TcasGA2_TC004550 [Tribolium castaneum] -- -- -- -- -- K00854 xylB, XYLB xylulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00854 O75191 1384 2.6e-151 Xylulose kinase OS=Homo sapiens GN=XYLB PE=1 SV=3 PF00370//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2531 Sugar (pentulose and hexulose) kinases Cluster-8309.24605 BP_3 333.00 6.14 2906 642935278 XP_008197945.1 2812 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase 4 [Tribolium castaneum] -- -- -- -- -- K12353 SMPD4 sphingomyelin phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12353 Q5XHG1 708 6.2e-73 Sphingomyelin phosphodiesterase 4 OS=Xenopus laevis GN=smpd4 PE=2 SV=2 PF14724 Mitochondrial-associated sphingomyelin phosphodiesterase GO:0006687 glycosphingolipid metabolic process GO:0050290 sphingomyelin phosphodiesterase D activity -- -- -- -- Cluster-8309.24606 BP_3 12.00 1.46 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24607 BP_3 6.08 0.50 877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24608 BP_3 5.16 1.39 471 332376935 AEE63607.1 134 8.8e-06 unknown [Dendroctonus ponderosae]>gi|478259710|gb|ENN79554.1| hypothetical protein YQE_04016, partial [Dendroctonus ponderosae]>gi|546676265|gb|ERL87311.1| hypothetical protein D910_04706 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24609 BP_3 426.91 11.71 2049 646717950 KDR20605.1 2455 2.8e-274 Elongator complex protein 3 [Zootermopsis nevadensis] 766940529 XM_011504565.1 409 0 PREDICTED: Ceratosolen solmsi marchali probable elongator complex protein 3 (LOC105366209), transcript variant X1, mRNA K07739 ELP3, KAT9 elongator complex protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07739 Q9VQZ6 2407 4.3e-270 Probable elongator complex protein 3 OS=Drosophila melanogaster GN=Elp3 PE=2 SV=1 PF13508//PF00583//PF04055 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Radical SAM superfamily GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0051536//GO:0003824 N-acetyltransferase activity//iron-sulfur cluster binding//catalytic activity -- -- KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase Cluster-8309.24614 BP_3 232.00 12.52 1185 817052027 XP_012254097.1 381 5.1e-34 PREDICTED: coiled-coil domain-containing protein 12 [Athalia rosae] -- -- -- -- -- K12871 CCDC12 coiled-coil domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K12871 Q8WUD4 288 1.3e-24 Coiled-coil domain-containing protein 12 OS=Homo sapiens GN=CCDC12 PE=1 SV=1 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0000166//GO:0004814 ATP binding//nucleotide binding//arginine-tRNA ligase activity GO:0005737 cytoplasm KOG3407 Uncharacterized conserved protein Cluster-8309.24618 BP_3 62.81 2.59 1461 642914466 XP_008201689.1 1114 6.3e-119 PREDICTED: uncharacterized protein LOC100142496 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24620 BP_3 9.00 0.99 731 478252126 ENN72557.1 316 1.1e-26 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.24621 BP_3 1.00 16.87 230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.24622 BP_3 21.63 0.36 3208 270014457 EFA10905.1 278 1.2e-21 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF00098//PF01807//PF16588 Zinc-finger associated domain (zf-AD)//Zinc knuckle//CHC2 zinc finger//C2H2 zinc-finger GO:0006351//GO:0006269//GO:0006260 transcription, DNA-templated//DNA replication, synthesis of RNA primer//DNA replication GO:0003677//GO:0003896//GO:0003676//GO:0008270 DNA binding//DNA primase activity//nucleic acid binding//zinc ion binding GO:0005657//GO:0005634//GO:0005730 replication fork//nucleus//nucleolus -- -- Cluster-8309.24623 BP_3 50.51 0.74 3578 270014457 EFA10905.1 278 1.4e-21 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.24624 BP_3 876.29 10.76 4216 91083325 XP_974870.1 5054 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB1 [Tribolium castaneum] 749796549 XM_011153388.1 449 0 PREDICTED: Harpegnathos saltator E3 ubiquitin-protein ligase MIB1 (LOC105190589), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q86YT6 3873 0.0e+00 E3 ubiquitin-protein ligase MIB1 OS=Homo sapiens GN=MIB1 PE=1 SV=1 PF13639//PF06701//PF00023//PF07664//PF00569//PF00097//PF14634//PF13606 Ring finger domain//Mib_herc2//Ankyrin repeat//Ferrous iron transport protein B C terminus//Zinc finger, ZZ type//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Ankyrin repeat GO:0016567//GO:0015684 protein ubiquitination//ferrous iron transport GO:0005515//GO:0004842//GO:0015093//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//ferrous iron transmembrane transporter activity//metal ion binding//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.24625 BP_3 817.42 17.59 2532 390198530 AFL70632.1 2679 3.7e-300 putative hypoxia-inducible factor 1 beta [Callosobruchus maculatus] 820805517 KP147913.1 493 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1779 3.5e-197 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.24629 BP_3 643.07 8.30 4025 642940390 XP_008200542.1 2415 2.4e-269 PREDICTED: chitin deacetylase 5 isoform X3 [Tribolium castaneum] 827560342 XM_012695639.1 311 2.38776e-159 PREDICTED: Bombyx mori uncharacterized LOC101740429 (LOC101740429), mRNA -- -- -- -- -- -- -- -- PF01522 Polysaccharide deacetylase GO:0005975//GO:0006807 carbohydrate metabolic process//nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.24630 BP_3 890.84 16.32 2923 270015294 EFA11742.1 905 2.2e-94 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06350//PF11435 Hormone-sensitive lipase (HSL) N-terminus//RNA binding protein She2p GO:0016042//GO:0008203 lipid catabolic process//cholesterol metabolic process GO:0016298//GO:0003723 lipase activity//RNA binding -- -- -- -- Cluster-8309.24631 BP_3 1.00 2.07 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24634 BP_3 357.41 4.79 3887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- -- -- Cluster-8309.24635 BP_3 1908.23 28.18 3555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- -- -- Cluster-8309.24636 BP_3 5403.20 83.57 3408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- -- -- Cluster-8309.24637 BP_3 43.00 2.20 1232 233957366 ACQ91223.1 1752 5.6e-193 ribosomal protein L3 [Penaeus monodon] 699671850 XM_009902564.1 288 4.37509e-147 PREDICTED: Picoides pubescens ribosomal protein L3 (RPL3), mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 1636 6.5e-181 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.24639 BP_3 20.89 0.54 2154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24644 BP_3 39.29 0.53 3859 642923805 XP_008193890.1 1839 1.4e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 7.6e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.24645 BP_3 47.00 1.53 1772 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24646 BP_3 23.99 0.55 2392 91079416 XP_967408.1 1515 3.3e-165 PREDICTED: microspherule protein 1 isoform X1 [Tribolium castaneum]>gi|270004380|gb|EFA00828.1| hypothetical protein TcasGA2_TC003716 [Tribolium castaneum] -- -- -- -- -- K11674 MCRS1, INO80Q microspherule protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11674 Q99L90 865 3.2e-91 Microspherule protein 1 OS=Mus musculus GN=Mcrs1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2293 Daxx-interacting protein MSP58/p78, contains FHA domain Cluster-8309.24647 BP_3 35.56 2.28 1045 332376342 AEE63311.1 757 1.1e-77 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01443 nagA, AMDHD2 N-acetylglucosamine-6-phosphate deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K01443 Q9VR81 709 1.7e-73 Putative N-acetylglucosamine-6-phosphate deacetylase OS=Drosophila melanogaster GN=CG17065 PE=2 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3892 N-acetyl-glucosamine-6-phosphate deacetylase Cluster-8309.24648 BP_3 46.31 1.63 1658 642916321 XP_008190972.1 316 2.5e-26 PREDICTED: uncharacterized protein LOC103312341 [Tribolium castaneum] 642916320 XM_008192750.1 163 1.82108e-77 PREDICTED: Tribolium castaneum uncharacterized LOC103312341 (LOC103312341), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2465 BP_3 1.00 0.88 340 755953710 XP_011302518.1 133 8.3e-06 PREDICTED: mucin-12 [Fopius arisanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.24652 BP_3 625.80 9.18 3578 642927427 XP_008195268.1 1097 1.5e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF16622 Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.24654 BP_3 82.25 1.50 2930 91081873 XP_968521.1 958 1.6e-100 PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|642921577|ref|XP_008192430.1| PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|270005016|gb|EFA01464.1| hypothetical protein TcasGA2_TC007010 [Tribolium castaneum] 462361277 APGK01029116.1 57 2.73179e-18 Dendroctonus ponderosae Seq01029126, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF00612//PF05531 IQ calmodulin-binding motif//Nucleopolyhedrovirus P10 protein -- -- GO:0005515 protein binding GO:0019028 viral capsid -- -- Cluster-8309.24655 BP_3 437.94 14.26 1772 642939029 XP_008200194.1 621 1.1e-61 PREDICTED: uncharacterized protein LOC103314860 [Tribolium castaneum]>gi|270016275|gb|EFA12721.1| hypothetical protein TcasGA2_TC002356 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D722 128 6.8e-06 Oxidative stress-responsive serine-rich protein 1 OS=Mus musculus GN=Oser1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24657 BP_3 507.15 11.16 2483 195126088 XP_002007506.1 1447 2.6e-157 GI12352 [Drosophila mojavensis]>gi|193919115|gb|EDW17982.1| GI12352 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- P51523 666 3.9e-68 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF05645//PF13912//PF13465//PF00096 RNA polymerase III subunit RPC82//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0005488//GO:0046872//GO:0003899//GO:0003677 binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.24658 BP_3 55.85 1.01 2950 195126088 XP_002007506.1 1447 3.1e-157 GI12352 [Drosophila mojavensis]>gi|193919115|gb|EDW17982.1| GI12352 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- P51523 666 4.7e-68 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13465//PF00096//PF05645//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//RNA polymerase III subunit RPC82//C2H2-type zinc finger GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0005488//GO:0046872//GO:0003677//GO:0003899 binding//metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.24659 BP_3 44.53 0.59 3902 270003335 EEZ99782.1 1012 1.1e-106 hypothetical protein TcasGA2_TC002561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJK0 545 6.6e-54 Ras-specific guanine nucleotide-releasing factor RalGPS1 OS=Gallus gallus GN=RALGPS1 PE=2 SV=1 PF04636//PF05767//PF00617 PA26 p53-induced protein (sestrin)//Poxvirus virion envelope protein A14//RasGEF domain GO:1901031//GO:0007264//GO:0043087 regulation of response to reactive oxygen species//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0019031//GO:0005634 viral envelope//nucleus KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.2466 BP_3 4.82 0.31 1037 675377463 KFM70365.1 342 1.5e-29 Chondroitin proteoglycan 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P29030 138 2.8e-07 Endochitinase OS=Brugia malayi PE=1 SV=1 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.24660 BP_3 3179.64 26.23 6134 189242026 XP_968092.2 2096 3.6e-232 PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938706|ref|XP_008196798.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938708|ref|XP_008196803.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938710|ref|XP_008196809.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938712|ref|XP_008196813.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938715|ref|XP_008196822.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|270015800|gb|EFA12248.1| hypothetical protein TcasGA2_TC016108 [Tribolium castaneum] 675175042 XM_008898158.1 35 9.76943e-06 Phytophthora parasitica INRA-310 hypothetical protein mRNA -- -- -- -- Q96NB2 1019 1.1e-108 Sideroflexin-2 OS=Homo sapiens GN=SFXN2 PE=1 SV=2 PF03820 Tricarboxylate carrier GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.24661 BP_3 195.09 1.49 6621 642931369 XP_008196550.1 7264 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931364 XM_008198326.1 1384 0 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X4, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q7PHR1 5861 0.0e+00 Kinesin-like protein unc-104 OS=Anopheles gambiae GN=unc-104 PE=3 SV=3 PF00225//PF06414//PF10390//PF00498//PF00959//PF07353//PF05171//PF05014 Kinesin motor domain//Zeta toxin//RNA polymerase II elongation factor ELL//FHA domain//Phage lysozyme//Uroplakin II//Haemin-degrading HemS.ChuX domain//Nucleoside 2-deoxyribosyltransferase GO:0006368//GO:0016998//GO:0006206//GO:0007018//GO:0009159//GO:0009253//GO:0061024//GO:0007017//GO:0005975//GO:0006826 transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process//pyrimidine nucleobase metabolic process//microtubule-based movement//deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process//membrane organization//microtubule-based process//carbohydrate metabolic process//iron ion transport GO:0003777//GO:0005515//GO:0003796//GO:0070694//GO:0008017//GO:0005524//GO:0050144//GO:0016301 microtubule motor activity//protein binding//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//microtubule binding//ATP binding//nucleoside deoxyribosyltransferase activity//kinase activity GO:0030176//GO:0008023//GO:0005874//GO:0045298 integral component of endoplasmic reticulum membrane//transcription elongation factor complex//microtubule//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.24662 BP_3 36.00 5.14 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05112 Baculovirus P47 protein GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.24663 BP_3 2023.17 42.43 2590 282158099 NP_001164093.1 2349 7.0e-262 SNF1A/AMP-activated protein kinase [Tribolium castaneum]>gi|270010962|gb|EFA07410.1| SNF1A/AMP-activated protein kinase [Tribolium castaneum] 815926247 XM_012392281.1 380 0 PREDICTED: Bombus impatiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 (LOC100744469), transcript variant X4, mRNA K07198 PRKAA, AMPK 5'-AMP-activated protein kinase, catalytic alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07198 Q28948 1757 1.3e-194 5'-AMP-activated protein kinase catalytic subunit alpha-2 OS=Sus scrofa GN=PRKAA2 PE=2 SV=2 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674//GO:0016773 ATP binding//protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0583 Serine/threonine protein kinase Cluster-8309.24664 BP_3 21.15 0.77 1621 478264795 ENN82329.1 823 3.9e-85 hypothetical protein YQE_01295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 6.8e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.24667 BP_3 89.98 11.11 682 91079008 XP_974790.1 605 3.1e-60 PREDICTED: ubiquitin-conjugating enzyme E2 W [Tribolium castaneum]>gi|642916289|ref|XP_008190962.1| PREDICTED: ubiquitin-conjugating enzyme E2 W [Tribolium castaneum]>gi|270003673|gb|EFA00121.1| hypothetical protein TcasGA2_TC002937 [Tribolium castaneum] 642916290 XM_969697.2 203 4.22517e-100 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2 W (LOC663661), transcript variant X2, mRNA K10688 UBE2W, UBC16 ubiquitin-conjugating enzyme E2 W http://www.genome.jp/dbget-bin/www_bget?ko:K10688 Q28FC1 557 4.7e-56 Ubiquitin-conjugating enzyme E2 W OS=Xenopus tropicalis GN=ube2w PE=2 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515//GO:0016881 protein binding//acid-amino acid ligase activity -- -- KOG0427 Ubiquitin conjugating enzyme Cluster-8309.24669 BP_3 619.00 35.13 1141 91079008 XP_974790.1 790 1.8e-81 PREDICTED: ubiquitin-conjugating enzyme E2 W [Tribolium castaneum]>gi|642916289|ref|XP_008190962.1| PREDICTED: ubiquitin-conjugating enzyme E2 W [Tribolium castaneum]>gi|270003673|gb|EFA00121.1| hypothetical protein TcasGA2_TC002937 [Tribolium castaneum] 642916290 XM_969697.2 241 5.42417e-121 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2 W (LOC663661), transcript variant X2, mRNA K10688 UBE2W, UBC16 ubiquitin-conjugating enzyme E2 W http://www.genome.jp/dbget-bin/www_bget?ko:K10688 Q28FC1 646 3.8e-66 Ubiquitin-conjugating enzyme E2 W OS=Xenopus tropicalis GN=ube2w PE=2 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0016881//GO:0005515 acid-amino acid ligase activity//protein binding -- -- KOG0427 Ubiquitin conjugating enzyme Cluster-8309.24671 BP_3 50.94 5.10 773 642927957 XP_008195462.1 274 8.5e-22 PREDICTED: transcriptional adapter 2B [Tribolium castaneum]>gi|270009831|gb|EFA06279.1| hypothetical protein TcasGA2_TC009145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04433 SWIRM domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24673 BP_3 283.68 6.58 2369 91093989 XP_970414.1 1011 9.0e-107 PREDICTED: golgin-45 [Tribolium castaneum]>gi|270016104|gb|EFA12552.1| hypothetical protein TcasGA2_TC001960 [Tribolium castaneum] 801398575 XM_012204360.1 66 2.18834e-23 PREDICTED: Atta cephalotes uncharacterized LOC105622954 (LOC105622954), mRNA -- -- -- -- Q9H2G9 263 2.0e-21 Golgin-45 OS=Homo sapiens GN=BLZF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4074 Leucine zipper nuclear factor Cluster-8309.24679 BP_3 2.00 1.10 377 645008246 XP_008203904.1 406 2.0e-37 PREDICTED: fatty acid synthase-like isoform X2 [Nasonia vitripennis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 339 4.9e-31 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.24681 BP_3 512.18 9.61 2861 91088445 XP_968690.1 1260 1.5e-135 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 857 3.2e-90 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF07497//PF00515//PF13371//PF04658//PF13176//PF00520//PF13414//PF13181//PF04564//PF02465 Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//TAFII55 protein conserved region//Tetratricopeptide repeat//Ion transport protein//TPR repeat//Tetratricopeptide repeat//U-box domain//Flagellar hook-associated protein 2 N-terminus GO:0055085//GO:0016567//GO:0006353//GO:0006367//GO:0006811 transmembrane transport//protein ubiquitination//DNA-templated transcription, termination//transcription initiation from RNA polymerase II promoter//ion transport GO:0003723//GO:0004842//GO:0005515//GO:0005216 RNA binding//ubiquitin-protein transferase activity//protein binding//ion channel activity GO:0000151//GO:0016020//GO:0009424//GO:0005669 ubiquitin ligase complex//membrane//bacterial-type flagellum hook//transcription factor TFIID complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.24683 BP_3 1004.45 10.28 5003 642919183 XP_008191772.1 3011 0.0e+00 PREDICTED: uncharacterized protein LOC103312580 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24686 BP_3 15.60 1.02 1029 225543108 NP_001139415.1 219 2.7e-15 sex lethal [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.24688 BP_3 1063.56 26.20 2248 91077894 XP_973141.1 1322 7.4e-143 PREDICTED: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [Tribolium castaneum]>gi|270001465|gb|EEZ97912.1| hypothetical protein TcasGA2_TC000297 [Tribolium castaneum] 704568790 XM_010186488.1 35 3.5465e-06 PREDICTED: Mesitornis unicolor farnesyltransferase, CAAX box, alpha (FNTA), partial mRNA K05955 FNTA protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05955 P29702 867 1.8e-91 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Bos taurus GN=FNTA PE=2 SV=2 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- KOG0530 Protein farnesyltransferase, alpha subunit/protein geranylgeranyltransferase type I, alpha subunit Cluster-8309.2469 BP_3 12.00 1.44 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24692 BP_3 422.20 11.39 2078 642938569 XP_968860.2 1706 2.0e-187 PREDICTED: ceramide glucosyltransferase-B [Tribolium castaneum] -- -- -- -- -- K00720 UGCG ceramide glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00720 Q16739 1082 1.9e-116 Ceramide glucosyltransferase OS=Homo sapiens GN=UGCG PE=1 SV=1 PF13506 Glycosyl transferase family 21 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2547 Ceramide glucosyltransferase Cluster-8309.24695 BP_3 16.73 0.64 1546 755973580 XP_011307059.1 1196 2.1e-128 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial [Fopius arisanus] -- -- -- -- -- K00162 PDHB, pdhB pyruvate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00162 O44451 1002 2.7e-107 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Caenorhabditis elegans GN=pdhb-1 PE=1 SV=2 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.24696 BP_3 330.00 10.26 1842 189237781 XP_972376.2 1047 4.7e-111 PREDICTED: ras-related and estrogen-regulated growth inhibitor-like protein [Tribolium castaneum]>gi|270006779|gb|EFA03227.1| hypothetical protein TcasGA2_TC013156 [Tribolium castaneum] -- -- -- -- -- K17198 RERGL Ras-related and estrogen-regulated growth inhibitor-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17198 Q6DGN0 351 9.8e-32 Ras-related and estrogen-regulated growth inhibitor-like protein OS=Danio rerio GN=rergl PE=2 SV=1 PF01926//PF08477//PF03193//PF00071//PF00025 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Ras family//ADP-ribosylation factor family GO:0007264//GO:0006184 small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.24698 BP_3 48.52 0.86 3013 642914025 XP_968806.3 2198 2.6e-244 PREDICTED: cullin-5 [Tribolium castaneum] 642914024 XM_963713.3 380 0 PREDICTED: Tribolium castaneum cullin-5 (LOC657244), mRNA K10612 CUL5 cullin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10612 Q29425 1621 8.7e-179 Cullin-5 OS=Oryctolagus cuniculus GN=CUL5 PE=2 SV=3 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2285 E3 ubiquitin ligase, Cullin 1 component Cluster-8309.24699 BP_3 77.82 4.91 1055 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16818 Protein SLM4 GO:0016237//GO:0007165 lysosomal microautophagy//signal transduction -- -- GO:0034448 EGO complex -- -- Cluster-8309.24701 BP_3 3.00 0.33 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24702 BP_3 429.00 8.45 2738 546677053 ERL87962.1 2168 7.2e-241 hypothetical protein D910_05350 [Dendroctonus ponderosae] 734644669 XM_010753083.1 119 8.73021e-53 PREDICTED: Larimichthys crocea frizzled-7-A-like (LOC104936971), mRNA K02432 FZD1_7, fz frizzled 1/7 http://www.genome.jp/dbget-bin/www_bget?ko:K02432 Q9I9M5 1670 1.6e-184 Frizzled-1 OS=Xenopus laevis GN=fzd1 PE=2 SV=1 PF01392//PF01534//PF05923 Fz domain//Frizzled/Smoothened family membrane region//APC cysteine-rich region GO:0007166//GO:0016055 cell surface receptor signaling pathway//Wnt signaling pathway GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.24704 BP_3 372.63 3.40 5571 189241139 XP_973746.2 1033 6.0e-109 PREDICTED: mitoferrin-1 [Tribolium castaneum] -- -- -- -- -- K15113 SLC25A28_37, MFRN solute carrier family 25 (mitochondrial iron transporter), member 28/37 http://www.genome.jp/dbget-bin/www_bget?ko:K15113 Q9VAY3 718 8.2e-74 Mitoferrin OS=Drosophila melanogaster GN=mfrn PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0760 Mitochondrial carrier protein MRS3/4 Cluster-8309.24708 BP_3 435.63 1.89 11411 642929737 XP_008195956.1 3594 0.0e+00 PREDICTED: zinc finger SWIM domain-containing protein 6-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P217 2085 5.2e-232 Zinc finger SWIM domain-containing protein 5 OS=Homo sapiens GN=ZSWIM5 PE=2 SV=2 PF04851//PF02892//PF02724//PF02861//PF00570//PF01189//PF00270//PF05063//PF09382 Type III restriction enzyme, res subunit//BED zinc finger//CDC45-like protein//Clp amino terminal domain, pathogenicity island component//HRDC domain//16S rRNA methyltransferase RsmF//DEAD/DEAH box helicase//MT-A70//RQC domain GO:0006270//GO:0006139//GO:0006281//GO:0019538//GO:0006260 DNA replication initiation//nucleobase-containing compound metabolic process//DNA repair//protein metabolic process//DNA replication GO:0005524//GO:0003677//GO:0016787//GO:0043140//GO:0008168//GO:0003676 ATP binding//DNA binding//hydrolase activity//ATP-dependent 3'-5' DNA helicase activity//methyltransferase activity//nucleic acid binding GO:0005657//GO:0005622 replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.24710 BP_3 834.69 8.74 4893 189236172 XP_967164.2 2056 1.2e-227 PREDICTED: WD repeat-containing and planar cell polarity effector protein fritz [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VQ36 600 3.5e-60 WD repeat-containing and planar cell polarity effector protein fritz OS=Drosophila melanogaster GN=frtz PE=2 SV=1 PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.24712 BP_3 283.13 14.61 1226 478250773 ENN71265.1 427 2.4e-39 hypothetical protein YQE_12191, partial [Dendroctonus ponderosae]>gi|546673029|gb|ERL84715.1| hypothetical protein D910_02140 [Dendroctonus ponderosae] -- -- -- -- -- K14294 WIBG, PYM partner of Y14 and mago http://www.genome.jp/dbget-bin/www_bget?ko:K14294 Q2F5J3 285 2.9e-24 Partner of Y14 and mago OS=Bombyx mori GN=wibg PE=2 SV=1 PF07966//PF09317//PF09268 A1 Propeptide//Domain of unknown function (DUF1974)//Clathrin, heavy-chain linker GO:0006118//GO:0006508//GO:0055114//GO:0033539//GO:0016192//GO:0006886 obsolete electron transport//proteolysis//oxidation-reduction process//fatty acid beta-oxidation using acyl-CoA dehydrogenase//vesicle-mediated transport//intracellular protein transport GO:0003995//GO:0004190//GO:0005198 acyl-CoA dehydrogenase activity//aspartic-type endopeptidase activity//structural molecule activity GO:0030130//GO:0030132 clathrin coat of trans-Golgi network vesicle//clathrin coat of coated pit KOG4325 Uncharacterized conserved protein Cluster-8309.24713 BP_3 782.00 36.87 1314 91076078 XP_967638.1 641 4.0e-64 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|642911608|ref|XP_008200670.1| PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|642911610|ref|XP_008200671.1| PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|642911612|ref|XP_008200672.1| PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|270014694|gb|EFA11142.1| hypothetical protein TcasGA2_TC004743 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QPN6 237 1.2e-18 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.24714 BP_3 390.07 15.70 1489 642917191 XP_975978.2 154 1.3e-07 PREDICTED: active regulator of SIRT1-like [Tribolium castaneum]>gi|270004376|gb|EFA00824.1| hypothetical protein TcasGA2_TC003712 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529//PF00665 DHHC palmitoyltransferase//Integrase core domain GO:0015074 DNA integration GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.24716 BP_3 1.00 4.87 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24717 BP_3 47.79 0.78 3226 270002464 EEZ98911.1 1451 1.2e-157 hypothetical protein TcasGA2_TC004530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60299 397 8.0e-37 Leucine zipper putative tumor suppressor 3 OS=Homo sapiens GN=LZTS3 PE=2 SV=1 PF00769//PF10288//PF01008 Ezrin/radixin/moesin family//Cytoplasmic tRNA 2-thiolation protein 2//Initiation factor 2 subunit family GO:0034227//GO:0002098//GO:0044237 tRNA thio-modification//tRNA wobble uridine modification//cellular metabolic process GO:0008092//GO:0000049 cytoskeletal protein binding//tRNA binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm -- -- Cluster-8309.24718 BP_3 281.74 2.29 6217 91086901 XP_970921.1 1465 5.4e-159 PREDICTED: origin recognition complex subunit 4 [Tribolium castaneum]>gi|270010481|gb|EFA06929.1| hypothetical protein TcasGA2_TC009879 [Tribolium castaneum] -- -- -- -- -- K02606 ORC4 origin recognition complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02606 O43929 850 4.5e-89 Origin recognition complex subunit 4 OS=Homo sapiens GN=ORC4 PE=1 SV=2 PF13676//PF00005//PF03266//PF03193//PF01637//PF04517//PF05496//PF00437//PF00448//PF00580//PF03205//PF02367//PF00578//PF07728//PF00085//PF00004 TIR domain//ABC transporter//NTPase//Protein of unknown function, DUF258//Archaeal ATPase//Microvirus lysis protein (E), C terminus//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//UvrD/REP helicase N-terminal domain//Molybdopterin guanine dinucleotide synthesis protein B//Threonylcarbamoyl adenosine biosynthesis protein TsaE//AhpC/TSA family//AAA domain (dynein-related subfamily)//Thioredoxin//ATPase family associated with various cellular activities (AAA) GO:0006810//GO:0006281//GO:0006614//GO:0007165//GO:0055114//GO:0006260//GO:0006777//GO:0045454//GO:0019054//GO:0002949//GO:0006310 transport//DNA repair//SRP-dependent cotranslational protein targeting to membrane//signal transduction//oxidation-reduction process//DNA replication//Mo-molybdopterin cofactor biosynthetic process//cell redox homeostasis//modulation by virus of host process//tRNA threonylcarbamoyladenosine modification//DNA recombination GO:0003924//GO:0005524//GO:0098519//GO:0016209//GO:0016887//GO:0004857//GO:0005515//GO:0016491//GO:0003677//GO:0009378//GO:0005525 GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//antioxidant activity//ATPase activity//enzyme inhibitor activity//protein binding//oxidoreductase activity//DNA binding//four-way junction helicase activity//GTP binding GO:0000808//GO:0009379//GO:0005634//GO:0005657 origin recognition complex//Holliday junction helicase complex//nucleus//replication fork KOG2228 Origin recognition complex, subunit 4 Cluster-8309.24719 BP_3 1258.77 16.86 3891 506969311 AGM32999.1 970 8.4e-102 thioredoxin domain-containing protein, partial [Coptotermes formosanus] -- -- -- -- -- K02606 ORC4 origin recognition complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02606 O43929 581 4.4e-58 Origin recognition complex subunit 4 OS=Homo sapiens GN=ORC4 PE=1 SV=2 PF04517//PF05496//PF00437//PF00448//PF00005//PF13676//PF03266//PF03193//PF01637//PF07728//PF00085//PF00004//PF03205//PF02367//PF00503//PF00931//PF00578 Microvirus lysis protein (E), C terminus//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//ABC transporter//TIR domain//NTPase//Protein of unknown function, DUF258//Archaeal ATPase//AAA domain (dynein-related subfamily)//Thioredoxin//ATPase family associated with various cellular activities (AAA)//Molybdopterin guanine dinucleotide synthesis protein B//Threonylcarbamoyl adenosine biosynthesis protein TsaE//G-protein alpha subunit//NB-ARC domain//AhpC/TSA family GO:0055114//GO:0007186//GO:0006777//GO:0006281//GO:0006810//GO:0006614//GO:0007165//GO:0045454//GO:0006310//GO:0002949//GO:0019054 oxidation-reduction process//G-protein coupled receptor signaling pathway//Mo-molybdopterin cofactor biosynthetic process//DNA repair//transport//SRP-dependent cotranslational protein targeting to membrane//signal transduction//cell redox homeostasis//DNA recombination//tRNA threonylcarbamoyladenosine modification//modulation by virus of host process GO:0019001//GO:0016209//GO:0016887//GO:0003924//GO:0005524//GO:0098519//GO:0031683//GO:0009378//GO:0005525//GO:0004871//GO:0004857//GO:0043531//GO:0005515//GO:0016491 guanyl nucleotide binding//antioxidant activity//ATPase activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//G-protein beta/gamma-subunit complex binding//four-way junction helicase activity//GTP binding//signal transducer activity//enzyme inhibitor activity//ADP binding//protein binding//oxidoreductase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG2228 Origin recognition complex, subunit 4 Cluster-8309.2472 BP_3 5.22 0.49 802 270005718 EFA02166.1 586 5.8e-58 hypothetical protein TcasGA2_TC007821 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24722 BP_3 25.32 0.42 3220 332376993 AEE63636.1 2012 1.0e-222 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14304 NUP85 nuclear pore complex protein Nup85 http://www.genome.jp/dbget-bin/www_bget?ko:K14304 Q8R480 847 5.2e-89 Nuclear pore complex protein Nup85 OS=Mus musculus GN=Nup85 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24724 BP_3 205.00 6.82 1741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24727 BP_3 68.20 2.67 1521 780616929 XP_011698547.1 138 9.8e-06 PREDICTED: zinc finger BED domain-containing protein RICESLEEPER 2-like [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24729 BP_3 122.15 3.81 1836 531443907 AGT57833.1 1688 2.2e-185 cytochrome P450 306a1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K10720 PHM CYP306A1; ecdysteroid 25-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10720 Q9VWR5 864 3.2e-91 Cytochrome P450 306a1 OS=Drosophila melanogaster GN=phm PE=1 SV=1 PF00407//PF00067 Pathogenesis-related protein Bet v I family//Cytochrome P450 GO:0009607//GO:0006952//GO:0055114 response to biotic stimulus//defense response//oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.24731 BP_3 1237.27 42.74 1687 642931134 XP_008196457.1 1421 1.8e-154 PREDICTED: yellow-e3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17060 491 5.2e-48 Major royal jelly protein 3 OS=Apis mellifera GN=MRJP3 PE=1 SV=1 PF02978 Signal peptide binding domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle -- -- Cluster-8309.24733 BP_3 715.85 23.82 1740 531443907 AGT57833.1 1731 2.1e-190 cytochrome P450 306a1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K10720 PHM CYP306A1; ecdysteroid 25-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10720 Q9VWR5 907 3.1e-96 Cytochrome P450 306a1 OS=Drosophila melanogaster GN=phm PE=1 SV=1 PF00067//PF00407 Cytochrome P450//Pathogenesis-related protein Bet v I family GO:0055114//GO:0006952//GO:0009607 oxidation-reduction process//defense response//response to biotic stimulus GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.24734 BP_3 110.31 2.29 2610 642927837 XP_008195420.1 541 3.1e-52 PREDICTED: HSPB1-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19375 HSPBAP1 HSPB1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19375 Q96EW2 249 9.3e-20 HSPB1-associated protein 1 OS=Homo sapiens GN=HSPBAP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.24736 BP_3 315.00 4.88 3403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24737 BP_3 479.17 10.94 2402 546678378 ERL89011.1 667 7.1e-67 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 497 1.5e-48 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3936 Nitroreductases Cluster-8309.24739 BP_3 23.00 2.37 760 270012421 EFA08869.1 260 3.5e-20 hypothetical protein TcasGA2_TC006570 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.24740 BP_3 163.52 9.23 1146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24742 BP_3 22.54 0.72 1799 270005418 EFA01866.1 429 2.1e-39 hypothetical protein TcasGA2_TC007471 [Tribolium castaneum] -- -- -- -- -- K11405 HDAC8 histone deacetylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11405 Q8VH37 368 1.0e-33 Histone deacetylase 8 OS=Mus musculus GN=Hdac8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.24743 BP_3 74.12 2.43 1760 642929939 XP_008196034.1 980 2.6e-103 PREDICTED: nucleolar protein 4-like isoform X2 [Tribolium castaneum] 642929940 XM_008197813.1 280 1.76546e-142 PREDICTED: Tribolium castaneum nucleolar protein 4-like (LOC664605), transcript variant X3, mRNA -- -- -- -- O94818 393 1.3e-36 Nucleolar protein 4 OS=Homo sapiens GN=NOL4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24744 BP_3 320.31 4.98 3395 642929937 XP_008196033.1 1684 1.2e-184 PREDICTED: nucleolar protein 4-like isoform X1 [Tribolium castaneum] 642929936 XM_008197811.1 374 0 PREDICTED: Tribolium castaneum nucleolar protein 4-like (LOC664605), transcript variant X1, mRNA -- -- -- -- Q96MY1 448 1.0e-42 Nucleolar protein 4-like OS=Homo sapiens GN=NOL4L PE=1 SV=2 PF09026//PF03607 Centromere protein B dimerisation domain//Doublecortin GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0003682 DNA binding//chromatin binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region -- -- Cluster-8309.24745 BP_3 563.26 30.36 1186 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24748 BP_3 27.55 0.75 2066 91088421 XP_967011.1 289 4.1e-23 PREDICTED: activated RNA polymerase II transcriptional coactivator p15 [Tribolium castaneum]>gi|270012200|gb|EFA08648.1| hypothetical protein TcasGA2_TC006312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11031 175 2.8e-11 Activated RNA polymerase II transcriptional coactivator p15 OS=Mus musculus GN=Sub1 PE=1 SV=3 PF02229 Transcriptional Coactivator p15 (PC4) GO:0006355 regulation of transcription, DNA-templated GO:0003713//GO:0003677 transcription coactivator activity//DNA binding GO:0005667 transcription factor complex KOG2712 Transcriptional coactivator Cluster-8309.24750 BP_3 12.00 1.32 731 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24751 BP_3 708.71 13.84 2760 91088433 XP_967839.1 919 4.9e-96 PREDICTED: BTB/POZ domain-containing protein KCTD5 [Tribolium castaneum]>gi|270012205|gb|EFA08653.1| hypothetical protein TcasGA2_TC006318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5PKG7 639 5.9e-65 BTB/POZ domain-containing protein KCTD5 OS=Bos taurus GN=KCTD5 PE=2 SV=1 PF02214//PF00651 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- KOG2715 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.24752 BP_3 209.02 7.96 1558 91091360 XP_972551.1 1160 3.1e-124 PREDICTED: 26S protease regulatory subunit 8 [Tribolium castaneum] 242005916 XM_002423761.1 299 4.27294e-153 Pediculus humanus corporis 26S protease regulatory subunit, putative, mRNA K03066 PSMC5, RPT6 26S proteasome regulatory subunit T6 http://www.genome.jp/dbget-bin/www_bget?ko:K03066 O18413 1102 6.8e-119 26S protease regulatory subunit 8 OS=Drosophila melanogaster GN=Rpt6 PE=1 SV=2 PF00910//PF06414//PF02367//PF02562//PF07726//PF07724//PF00004//PF06009//PF06068//PF00158//PF05496//PF01057//PF07728//PF01383//PF01695 RNA helicase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Laminin Domain II//TIP49 C-terminus//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//Parvovirus non-structural protein NS1//AAA domain (dynein-related subfamily)//CpcD/allophycocyanin linker domain//IstB-like ATP binding protein GO:0006355//GO:0019079//GO:0006281//GO:0002949//GO:0007155//GO:0006310 regulation of transcription, DNA-templated//viral genome replication//DNA repair//tRNA threonylcarbamoyladenosine modification//cell adhesion//DNA recombination GO:0016301//GO:0016887//GO:0005524//GO:0008134//GO:0009378//GO:0003724//GO:0003678//GO:0003723 kinase activity//ATPase activity//ATP binding//transcription factor binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding GO:0030089//GO:0009379//GO:0005657//GO:0005667 phycobilisome//Holliday junction helicase complex//replication fork//transcription factor complex KOG0728 26S proteasome regulatory complex, ATPase RPT6 Cluster-8309.24753 BP_3 65.26 0.74 4556 19920408 NP_608447.1 1517 3.7e-165 regulatory particle triple-A ATPase 6 [Drosophila melanogaster]>gi|14286160|sp|O18413.2|PRS8_DROME RecName: Full=26S protease regulatory subunit 8>gi|2815905|gb|AAC63219.1| Pros45 proteosome subunit homolog [Drosophila melanogaster]>gi|7295522|gb|AAF50835.1| regulatory particle triple-A ATPase 6 [Drosophila melanogaster]>gi|15291775|gb|AAK93156.1| LD26005p [Drosophila melanogaster]>gi|220945798|gb|ACL85442.1| Pros45-PA, partial [synthetic construct]>gi|220955554|gb|ACL90320.1| Pros45-PA [synthetic construct] 242005916 XM_002423761.1 461 0 Pediculus humanus corporis 26S protease regulatory subunit, putative, mRNA K03066 PSMC5, RPT6 26S proteasome regulatory subunit T6 http://www.genome.jp/dbget-bin/www_bget?ko:K03066 O18413 1517 1.5e-166 26S protease regulatory subunit 8 OS=Drosophila melanogaster GN=Rpt6 PE=1 SV=2 PF00004//PF07724//PF01695//PF07728//PF01057//PF05496//PF00158//PF06068//PF00910//PF07726//PF02562//PF06414//PF02367 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//RNA helicase//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006355//GO:0019079//GO:0006974//GO:0006281//GO:0002949//GO:0006511//GO:0006310 regulation of transcription, DNA-templated//viral genome replication//cellular response to DNA damage stimulus//DNA repair//tRNA threonylcarbamoyladenosine modification//ubiquitin-dependent protein catabolic process//DNA recombination GO:0016301//GO:0016887//GO:0005524//GO:0008134//GO:0009378//GO:0003724//GO:0003678//GO:0003723//GO:0004175 kinase activity//ATPase activity//ATP binding//transcription factor binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding//endopeptidase activity GO:0005737//GO:0005875//GO:0009379//GO:0005657//GO:0005634//GO:0005667//GO:0008540 cytoplasm//microtubule associated complex//Holliday junction helicase complex//replication fork//nucleus//transcription factor complex//proteasome regulatory particle, base subcomplex KOG0728 26S proteasome regulatory complex, ATPase RPT6 Cluster-8309.24754 BP_3 545.70 4.30 6405 546680884 ERL91070.1 2675 2.7e-299 hypothetical protein D910_08412 [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 Q9NSI6 1521 7.3e-167 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens GN=BRWD1 PE=1 SV=4 PF13409//PF00400//PF10717//PF13417//PF02798//PF00439//PF06507 Glutathione S-transferase, N-terminal domain//WD domain, G-beta repeat//Occlusion-derived virus envelope protein ODV-E18//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Bromodomain//Auxin response factor GO:0009725//GO:0006355 response to hormone//regulation of transcription, DNA-templated GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634//GO:0019031 nucleus//viral envelope KOG0644 Uncharacterized conserved protein, contains WD40 repeat and BROMO domains Cluster-8309.24755 BP_3 115.31 5.72 1263 189239014 XP_974755.2 532 1.7e-51 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 212 8.8e-16 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24762 BP_3 63.27 1.77 2015 449083364 NP_001263355.1 852 2.1e-88 dehydrogenase/reductase SDR family member 4 [Tribolium castaneum]>gi|270003836|gb|EFA00284.1| hypothetical protein TcasGA2_TC003117 [Tribolium castaneum] -- -- -- -- -- K11147 DHRS4 dehydrogenase/reductase SDR family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11147 Q9GKX2 601 1.1e-60 Dehydrogenase/reductase SDR family member 4 (Fragment) OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.24763 BP_3 214.46 1.88 5787 350414142 XP_003490218.1 2125 1.5e-235 PREDICTED: protein O-GlcNAcase isoform X3 [Bombus impatiens] 830022072 XM_012723671.1 44 9.14856e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 1092 3.7e-117 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 PF09726//PF05418//PF13673//PF00736//PF06331 Transmembrane protein//Apovitellenin I (Apo-VLDL-II)//Acetyltransferase (GNAT) domain//EF-1 guanine nucleotide exchange domain//Transcription factor TFIIH complex subunit Tfb5 GO:0042967//GO:0006629//GO:0006448//GO:0006414//GO:0006289//GO:0006355 acyl-carrier-protein biosynthetic process//lipid metabolic process//regulation of translational elongation//translational elongation//nucleotide-excision repair//regulation of transcription, DNA-templated GO:0008080//GO:0004857//GO:0003746 N-acetyltransferase activity//enzyme inhibitor activity//translation elongation factor activity GO:0016021//GO:0042627//GO:0000439//GO:0005853//GO:0005840 integral component of membrane//chylomicron//core TFIIH complex//eukaryotic translation elongation factor 1 complex//ribosome KOG3698 Hyaluronoglucosaminidase Cluster-8309.24764 BP_3 2344.52 35.95 3435 642928838 XP_008195583.1 3915 0.0e+00 PREDICTED: uncharacterized protein LOC656400 [Tribolium castaneum] 642928837 XM_008197361.1 741 0 PREDICTED: Tribolium castaneum uncharacterized LOC656400 (LOC656400), mRNA -- -- -- -- Q8NBH2 372 6.7e-34 Kyphoscoliosis peptidase OS=Homo sapiens GN=KY PE=1 SV=2 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.24765 BP_3 23.33 1.73 940 751224154 XP_011165403.1 664 6.2e-67 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24766 BP_3 1429.35 94.60 1020 478250011 ENN70517.1 712 1.8e-72 hypothetical protein YQE_12693, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VTI8 333 6.6e-30 Protein charybde OS=Drosophila melanogaster GN=chrb PE=2 SV=2 PF01318//PF07809 Bromovirus coat protein//RTP801 C-terminal region GO:0009968 negative regulation of signal transduction GO:0005198 structural molecule activity GO:0019028//GO:0005737 viral capsid//cytoplasm -- -- Cluster-8309.24767 BP_3 1594.67 47.97 1894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24768 BP_3 2841.53 40.53 3671 91084037 XP_966813.1 440 2.3e-40 PREDICTED: putative defense protein Hdd11 [Tribolium castaneum]>gi|642924804|ref|XP_008194048.1| PREDICTED: putative defense protein Hdd11 [Tribolium castaneum]>gi|270006698|gb|EFA03146.1| hypothetical protein TcasGA2_TC013059 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q008X1 248 1.7e-19 Putative defense protein OS=Bombyx mori PE=2 SV=1 PF00864 ATP P2X receptor GO:0006812//GO:0007165//GO:0098655//GO:0033198 cation transport//signal transduction//cation transmembrane transport//response to ATP GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.2477 BP_3 42.00 0.45 4748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08502 LeuA allosteric (dimerisation) domain GO:0009099//GO:0006090//GO:0009098//GO:0009097 valine biosynthetic process//pyruvate metabolic process//leucine biosynthetic process//isoleucine biosynthetic process GO:0003852 2-isopropylmalate synthase activity -- -- -- -- Cluster-8309.24771 BP_3 11.00 5.01 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24773 BP_3 13.00 0.59 1350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24774 BP_3 157.47 5.40 1696 642916998 XP_001812033.2 195 2.7e-12 PREDICTED: uncharacterized protein LOC100142249 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24776 BP_3 52.87 0.53 5113 642915698 XP_008190764.1 2683 2.6e-300 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X2 [Tribolium castaneum] 642915699 XM_008192543.1 222 9.06905e-110 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 7.8e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.24779 BP_3 15.00 2.31 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24784 BP_3 3.00 0.57 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24790 BP_3 1008.61 11.65 4465 546686163 ERL95549.1 2201 1.7e-244 hypothetical protein D910_12810 [Dendroctonus ponderosae] -- -- -- -- -- K10273 FBXL7 F-box and leucine-rich repeat protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10273 Q5BJ29 991 1.5e-105 F-box/LRR-repeat protein 7 OS=Mus musculus GN=Fbxl7 PE=1 SV=1 PF00560//PF00481//PF00646//PF09029//PF15966//PF13516//PF12937 Leucine Rich Repeat//Protein phosphatase 2C//F-box domain//5-aminolevulinate synthase presequence//F-box//Leucine Rich repeat//F-box-like GO:0042967//GO:0006563//GO:0006544//GO:0006783//GO:0006778//GO:0006566 acyl-carrier-protein biosynthetic process//L-serine metabolic process//glycine metabolic process//heme biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process GO:0003870//GO:0005515//GO:0030170//GO:0003824 5-aminolevulinate synthase activity//protein binding//pyridoxal phosphate binding//catalytic activity GO:0005759 mitochondrial matrix KOG1323 Serine/threonine phosphatase Cluster-8309.24791 BP_3 54.39 0.62 4495 546686163 ERL95549.1 2199 3.0e-244 hypothetical protein D910_12810 [Dendroctonus ponderosae] -- -- -- -- -- K10273 FBXL7 F-box and leucine-rich repeat protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10273 Q5BJ29 991 1.5e-105 F-box/LRR-repeat protein 7 OS=Mus musculus GN=Fbxl7 PE=1 SV=1 PF13516//PF12937//PF00646//PF09262//PF15178//PF00560//PF15966//PF09029 Leucine Rich repeat//F-box-like//F-box domain//Peroxisome biogenesis factor 1, N-terminal//Mitochondrial import receptor subunit TOM5 homolog//Leucine Rich Repeat//F-box//5-aminolevulinate synthase presequence GO:0042967//GO:0006563//GO:0007031//GO:0006783//GO:0006544//GO:0006778//GO:0006566 acyl-carrier-protein biosynthetic process//L-serine metabolic process//peroxisome organization//heme biosynthetic process//glycine metabolic process//porphyrin-containing compound metabolic process//threonine metabolic process GO:0030170//GO:0003870//GO:0005515//GO:0005524 pyridoxal phosphate binding//5-aminolevulinate synthase activity//protein binding//ATP binding GO:0005777//GO:0005759//GO:0005742 peroxisome//mitochondrial matrix//mitochondrial outer membrane translocase complex KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.24792 BP_3 47.01 0.70 3520 642930730 XP_001807945.2 2981 0.0e+00 PREDICTED: TBC1 domain family member 16 [Tribolium castaneum] 462330734 APGK01039925.1 69 7.01882e-25 Dendroctonus ponderosae Seq01039935, whole genome shotgun sequence -- -- -- -- Q8TBP0 1284 1.2e-139 TBC1 domain family member 16 OS=Homo sapiens GN=TBC1D16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.24793 BP_3 88.92 0.80 5645 642938278 XP_008192712.1 3281 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 958 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.2e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF00069//PF07714//PF12142 Protein kinase domain//Protein tyrosine kinase//Polyphenol oxidase middle domain GO:0006118//GO:0006468//GO:0055114//GO:0006570 obsolete electron transport//protein phosphorylation//oxidation-reduction process//tyrosine metabolic process GO:0005524//GO:0004672//GO:0004097 ATP binding//protein kinase activity//catechol oxidase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.24794 BP_3 281.78 2.18 6536 642938278 XP_008192712.1 3281 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 958 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.4e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF12142//PF00069//PF07714 Polyphenol oxidase middle domain//Protein kinase domain//Protein tyrosine kinase GO:0055114//GO:0006468//GO:0006570//GO:0006118 oxidation-reduction process//protein phosphorylation//tyrosine metabolic process//obsolete electron transport GO:0004097//GO:0004672//GO:0005524 catechol oxidase activity//protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.24795 BP_3 231.27 2.01 5837 642938278 XP_008192712.1 3480 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 1092 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 Q9UKI8 1880 1.6e-208 Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens GN=TLK1 PE=1 SV=2 PF12142//PF07714//PF00069 Polyphenol oxidase middle domain//Protein tyrosine kinase//Protein kinase domain GO:0006570//GO:0006468//GO:0055114//GO:0006118 tyrosine metabolic process//protein phosphorylation//oxidation-reduction process//obsolete electron transport GO:0004097//GO:0004672//GO:0005524 catechol oxidase activity//protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.24796 BP_3 191.82 1.39 6935 -- -- -- -- -- 642938285 XM_008194514.1 89 1.05885e-35 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF09477 Bacterial type II secretion system chaperone protein (type_III_yscG) GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.24797 BP_3 3.00 1.10 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24801 BP_3 155.88 0.90 8636 478258659 ENN78709.1 2012 2.8e-222 hypothetical protein YQE_04881, partial [Dendroctonus ponderosae] 478512620 XM_004430515.1 38 2.96007e-07 PREDICTED: Ceratotherium simum simum death inducer-obliterator 1 (DIDO1), mRNA -- -- -- -- Q8BFT6 706 3.1e-72 JmjC domain-containing protein 4 OS=Mus musculus GN=Jmjd4 PE=2 SV=1 PF07500//PF06427//PF07533//PF00628 Transcription factor S-II (TFIIS), central domain//UDP-glucose:Glycoprotein Glucosyltransferase//BRK domain//PHD-finger GO:0006351//GO:0006486 transcription, DNA-templated//protein glycosylation GO:0016817//GO:0003980//GO:0005515 hydrolase activity, acting on acid anhydrides//UDP-glucose:glycoprotein glucosyltransferase activity//protein binding -- -- KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.2481 BP_3 4.00 0.32 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24812 BP_3 20.00 1.11 1160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24814 BP_3 1313.27 13.29 5056 478251476 ENN71939.1 1947 5.6e-215 hypothetical protein YQE_11373, partial [Dendroctonus ponderosae] 642917170 XM_966698.2 42 1.03302e-09 PREDICTED: Tribolium castaneum centrosomin (LOC660470), transcript variant X2, mRNA -- -- -- -- P54623 285 1.2e-23 Centrosomin OS=Drosophila melanogaster GN=cnn PE=1 SV=3 PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.24815 BP_3 293.26 27.17 812 91087357 XP_975625.1 881 3.7e-92 PREDICTED: ADP-ribosylation factor-like protein 2 [Tribolium castaneum]>gi|270010616|gb|EFA07064.1| hypothetical protein TcasGA2_TC010041 [Tribolium castaneum] -- -- -- -- -- K07943 ARL2 ADP-ribosylation factor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07943 P36404 783 3.5e-82 ADP-ribosylation factor-like protein 2 OS=Homo sapiens GN=ARL2 PE=1 SV=4 PF00503//PF04670//PF00025//PF00071//PF08477//PF01926 G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0019001//GO:0004871//GO:0005525//GO:0031683//GO:0003924 guanyl nucleotide binding//signal transducer activity//GTP binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0005622 intracellular KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2 Cluster-8309.24819 BP_3 6501.15 130.44 2694 642920699 XP_976218.2 426 7.0e-39 PREDICTED: mucin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2482 BP_3 5.00 0.82 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24823 BP_3 88.42 1.18 3895 642910866 XP_001813884.2 3458 0.0e+00 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1321 6.9e-144 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF02390//PF08123 Putative methyltransferase//Histone methylation protein DOT1 GO:0006400//GO:0006554//GO:0008033//GO:0009451//GO:0006479 tRNA modification//lysine catabolic process//tRNA processing//RNA modification//protein methylation GO:0018024//GO:0008176 histone-lysine N-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.24826 BP_3 82.84 1.49 2972 91082057 XP_971798.1 1924 1.5e-212 PREDICTED: mitochondrial chaperone BCS1 [Tribolium castaneum]>gi|270007281|gb|EFA03729.1| hypothetical protein TcasGA2_TC013838 [Tribolium castaneum] 815794844 XM_012362642.1 161 4.26014e-76 PREDICTED: Linepithema humile mitochondrial chaperone BCS1 (LOC105669594), mRNA K08900 BCS1 mitochondrial chaperone BCS1 http://www.genome.jp/dbget-bin/www_bget?ko:K08900 Q7ZV60 1367 2.4e-149 Mitochondrial chaperone BCS1 OS=Danio rerio GN=bcs1l PE=2 SV=2 PF06431//PF00910//PF00004//PF07728//PF00005 Polyomavirus large T antigen C-terminus//RNA helicase//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//ABC transporter GO:0006260 DNA replication GO:0003724//GO:0017111//GO:0016887//GO:0003677//GO:0003723//GO:0005524 RNA helicase activity//nucleoside-triphosphatase activity//ATPase activity//DNA binding//RNA binding//ATP binding -- -- KOG0743 AAA+-type ATPase Cluster-8309.24827 BP_3 11.66 0.35 1919 332373110 AEE61696.1 828 1.2e-85 unknown [Dendroctonus ponderosae] -- -- -- -- -- K06201 cutC copper homeostasis protein http://www.genome.jp/dbget-bin/www_bget?ko:K06201 Q9NTM9 492 4.6e-48 Copper homeostasis protein cutC homolog OS=Homo sapiens GN=CUTC PE=1 SV=1 PF03932//PF00121//PF02581//PF01025//PF01081 CutC family//Triosephosphate isomerase//Thiamine monophosphate synthase/TENI//GrpE//KDPG and KHG aldolase GO:0006020//GO:0009228//GO:0006457//GO:0008152//GO:0055070//GO:0006013//GO:0015976//GO:0006096//GO:0046486//GO:0006000//GO:0006094 inositol metabolic process//thiamine biosynthetic process//protein folding//metabolic process//copper ion homeostasis//mannose metabolic process//carbon utilization//glycolytic process//glycerolipid metabolic process//fructose metabolic process//gluconeogenesis GO:0004789//GO:0005507//GO:0042803//GO:0004807//GO:0016829//GO:0000774//GO:0051087 thiamine-phosphate diphosphorylase activity//copper ion binding//protein homodimerization activity//triose-phosphate isomerase activity//lyase activity//adenyl-nucleotide exchange factor activity//chaperone binding -- -- KOG4013 Predicted Cu2+ homeostasis protein CutC Cluster-8309.24829 BP_3 1.00 1.93 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24833 BP_3 1514.25 15.57 4979 546678097 ERL88806.1 2073 1.4e-229 hypothetical protein D910_06188 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.24834 BP_3 228.03 1.92 6012 546678097 ERL88806.1 2080 2.5e-230 hypothetical protein D910_06188 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01150//PF09194 GDA1/CD39 (nucleoside phosphatase) family//Restriction endonuclease BsobI GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0009036//GO:0016787//GO:0003677 Type II site-specific deoxyribonuclease activity//hydrolase activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.24835 BP_3 51.84 0.73 3738 642917468 XP_008191214.1 2640 1.8e-295 PREDICTED: ral guanine nucleotide dissociation stimulator-like 1 isoform X6 [Tribolium castaneum] -- -- -- -- -- K17635 RGL1, RGL ral guanine nucleotide dissociation stimulator-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17635 Q9NZL6 962 2.8e-102 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00617//PF00788 RasGEF domain//Ras association (RalGDS/AF-6) domain GO:0007264//GO:0007165//GO:0043087 small GTPase mediated signal transduction//signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.24836 BP_3 265.30 4.93 2887 642917459 XP_008191209.1 2783 0.0e+00 PREDICTED: ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17635 RGL1, RGL ral guanine nucleotide dissociation stimulator-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17635 Q9NZL6 962 2.2e-102 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00617//PF04604//PF00788 RasGEF domain//Type-A lantibiotic//Ras association (RalGDS/AF-6) domain GO:0007264//GO:0043087//GO:0042742//GO:0007165 small GTPase mediated signal transduction//regulation of GTPase activity//defense response to bacterium//signal transduction GO:0005085 guanyl-nucleotide exchange factor activity GO:0005576 extracellular region KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.24838 BP_3 475.59 11.28 2324 642921260 XP_008192789.1 1024 2.7e-108 PREDICTED: serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [Tribolium castaneum] 573910381 XM_006642846.1 228 1.88954e-113 PREDICTED: Lepisosteus oculatus serine/threonine-protein phosphatase PP1-beta catalytic subunit-like (LOC102696354), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q5I085 969 2.7e-103 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Xenopus tropicalis GN=ppp1cb PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.2484 BP_3 22.14 0.61 2048 857977403 CEO96801.1 261 7.2e-20 hypothetical protein PBRA_005405 [Plasmodiophora brassicae] 697086959 XM_009658097.1 1845 0 Verticillium dahliae VdLs.17 zinc/iron transporter protein partial mRNA -- -- -- -- Q8S3W4 216 4.9e-16 Probable zinc transporter 8 OS=Arabidopsis thaliana GN=ZIP8 PE=2 SV=1 PF04750//PF02535 FAR-17a/AIG1-like protein//ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.24840 BP_3 260.16 20.02 918 91078504 XP_969393.1 768 5.2e-79 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X2 [Tribolium castaneum] 572317140 XM_006624116.1 117 3.69707e-52 PREDICTED: Apis dorsata uncharacterized LOC102679271 (LOC102679271), transcript variant X4, mRNA -- -- -- -- Q8IQC1 545 1.6e-54 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.24844 BP_3 378.42 15.57 1463 478254261 ENN74515.1 701 4.9e-71 hypothetical protein YQE_08839, partial [Dendroctonus ponderosae] -- -- -- -- -- K01080 PPAP2 phosphatidate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01080 Q61469 247 8.9e-20 Lipid phosphate phosphohydrolase 1 OS=Mus musculus GN=Ppap2a PE=1 SV=1 PF03600 Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG3030 Lipid phosphate phosphatase and related enzymes of the PAP2 family Cluster-8309.24846 BP_3 614.54 5.01 6209 642910889 XP_008193451.1 3859 0.0e+00 PREDICTED: SLIT-ROBO Rho GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] 805778458 XM_012283126.1 285 1.04941e-144 PREDICTED: Megachile rotundata SLIT-ROBO Rho GTPase-activating protein 1 (LOC100883803), transcript variant X1, mRNA K07526 SRGAP SLIT-ROBO Rho GTPase activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K07526 Q7Z6B7 1641 8.6e-181 SLIT-ROBO Rho GTPase-activating protein 1 OS=Homo sapiens GN=SRGAP1 PE=1 SV=1 PF02321//PF16740//PF14604//PF00018//PF00620 Outer membrane efflux protein//Spindle and kinetochore-associated protein 2//Variant SH3 domain//SH3 domain//RhoGAP domain GO:0007165//GO:0006810//GO:0007067//GO:0000090//GO:0031110//GO:0051301//GO:0007059 signal transduction//transport//mitotic nuclear division//mitotic anaphase//regulation of microtubule polymerization or depolymerization//cell division//chromosome segregation GO:0005215//GO:0005515//GO:0008017 transporter activity//protein binding//microtubule binding GO:0045298//GO:0000940//GO:0005876 tubulin complex//condensed chromosome outer kinetochore//spindle microtubule -- -- Cluster-8309.24847 BP_3 127.91 3.45 2078 91089077 XP_971296.1 743 9.4e-76 PREDICTED: density-regulated protein [Tribolium castaneum]>gi|270012410|gb|EFA08858.1| hypothetical protein TcasGA2_TC006559 [Tribolium castaneum] 389609388 AK401684.1 173 6.32862e-83 Papilio xuthus mRNA for similar to CG9099, complete cds, sequence id: Px-1124 -- -- -- -- Q9VX98 667 2.5e-68 Density-regulated protein homolog OS=Drosophila melanogaster GN=DENR PE=1 SV=3 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG3239 Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.24850 BP_3 527.71 12.79 2280 546675694 ERL86836.1 2045 1.1e-226 hypothetical protein D910_04239 [Dendroctonus ponderosae] -- -- -- -- -- K15865 CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15865 Q291H5 1851 1.4e-205 Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Drosophila pseudoobscura pseudoobscura GN=GA19679 PE=3 SV=1 PF06444//PF04055//PF02627//PF00919 NADH dehydrogenase subunit 2 C-terminus//Radical SAM superfamily//Carboxymuconolactone decarboxylase family//Uncharacterized protein family UPF0004 GO:0006120//GO:0006814//GO:0006744//GO:0009451//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//ubiquinone biosynthetic process//RNA modification//proton transport//oxidation-reduction process GO:0003824//GO:0051920//GO:0051536//GO:0051539//GO:0008137 catalytic activity//peroxiredoxin activity//iron-sulfur cluster binding//4 iron, 4 sulfur cluster binding//NADH dehydrogenase (ubiquinone) activity -- -- KOG2492 CDK5 activator-binding protein Cluster-8309.24855 BP_3 9.76 0.69 973 641655926 XP_008179777.1 465 7.6e-44 PREDICTED: zinc finger MYM-type protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q5SVZ6 226 1.6e-17 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 PF00872 Transposase, Mutator family GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-8309.24856 BP_3 2.00 2.69 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24858 BP_3 211.89 11.28 1197 642925663 XP_008194660.1 1300 1.4e-140 PREDICTED: BRCA1-associated protein [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 616 1.2e-62 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF02148//PF12678//PF17123//PF00628//PF14634//PF00097//PF13639//PF12861 Zn-finger in ubiquitin-hydrolases and other protein//RING-H2 zinc finger//RING-like zinc finger//PHD-finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.24859 BP_3 158.07 9.48 1095 270008898 EFA05346.1 849 2.5e-88 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 450 1.9e-43 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF17078//PF04513//PF02601//PF07926//PF04728//PF16740//PF13851//PF06005//PF00170//PF01297//PF04632//PF02148//PF06156//PF04111//PF07851 SWI5-dependent HO expression protein 3//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//TPR/MLP1/MLP2-like protein//Lipoprotein leucine-zipper//Spindle and kinetochore-associated protein 2//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//bZIP transcription factor//Zinc-uptake complex component A periplasmic//Fusaric acid resistance protein family//Zn-finger in ubiquitin-hydrolases and other protein//Protein of unknown function (DUF972)//Autophagy protein Apg6//TMPIT-like protein GO:0006810//GO:0006914//GO:0031110//GO:0006355//GO:0007067//GO:0000090//GO:0007059//GO:0030001//GO:0043093//GO:0000917//GO:0006308//GO:0006260//GO:0051301//GO:0006606//GO:0048309//GO:0048870//GO:0051028 transport//autophagy//regulation of microtubule polymerization or depolymerization//regulation of transcription, DNA-templated//mitotic nuclear division//mitotic anaphase//chromosome segregation//metal ion transport//FtsZ-dependent cytokinesis//barrier septum assembly//DNA catabolic process//DNA replication//cell division//protein import into nucleus//endoplasmic reticulum inheritance//cell motility//mRNA transport GO:0005198//GO:0008270//GO:0043565//GO:0008855//GO:0008017//GO:0003700//GO:0046872 structural molecule activity//zinc ion binding//sequence-specific DNA binding//exodeoxyribonuclease VII activity//microtubule binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0031514//GO:0016021//GO:0005737//GO:0005876//GO:0005886//GO:0019867//GO:0019031//GO:0000940//GO:0019028//GO:0045298//GO:0009318//GO:0005667 motile cilium//integral component of membrane//cytoplasm//spindle microtubule//plasma membrane//outer membrane//viral envelope//condensed chromosome outer kinetochore//viral capsid//tubulin complex//exodeoxyribonuclease VII complex//transcription factor complex KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.24860 BP_3 9.02 0.47 1223 270008898 EFA05346.1 735 4.7e-75 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 407 2.1e-38 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF00170//PF13851//PF06005//PF01920//PF02148//PF04111//PF06156//PF01297//PF03255//PF04513//PF01025//PF00038//PF10473//PF03938//PF07926 bZIP transcription factor//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//Prefoldin subunit//Zn-finger in ubiquitin-hydrolases and other protein//Autophagy protein Apg6//Protein of unknown function (DUF972)//Zinc-uptake complex component A periplasmic//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//GrpE//Intermediate filament protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Outer membrane protein (OmpH-like)//TPR/MLP1/MLP2-like protein GO:0006914//GO:0006355//GO:0030001//GO:0006457//GO:0000917//GO:0043093//GO:0006606//GO:0006090//GO:0006260//GO:0048870//GO:0006633 autophagy//regulation of transcription, DNA-templated//metal ion transport//protein folding//barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//pyruvate metabolic process//DNA replication//cell motility//fatty acid biosynthetic process GO:0005198//GO:0043565//GO:0008270//GO:0000774//GO:0042803//GO:0008134//GO:0045502//GO:0003700//GO:0051082//GO:0051087//GO:0003989//GO:0046872 structural molecule activity//sequence-specific DNA binding//zinc ion binding//adenyl-nucleotide exchange factor activity//protein homodimerization activity//transcription factor binding//dynein binding//transcription factor activity, sequence-specific DNA binding//unfolded protein binding//chaperone binding//acetyl-CoA carboxylase activity//metal ion binding GO:0031514//GO:0005737//GO:0009317//GO:0019031//GO:0005882//GO:0019028//GO:0016272//GO:0005667//GO:0030286 motile cilium//cytoplasm//acetyl-CoA carboxylase complex//viral envelope//intermediate filament//viral capsid//prefoldin complex//transcription factor complex//dynein complex KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.24861 BP_3 672.52 6.93 4967 642925075 XP_008194159.1 2846 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X3 [Tribolium castaneum] 642925074 XM_008195937.1 248 3.10148e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 215 1.6e-15 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF05792//PF04988//PF00096//PF13465 Candida agglutinin-like (ALS)//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0007155 cell adhesion GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.24863 BP_3 8.00 0.34 1426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06971 Putative DNA-binding protein N-terminus GO:0051775//GO:0045892 response to redox state//negative regulation of transcription, DNA-templated -- -- GO:0005737 cytoplasm -- -- Cluster-8309.24864 BP_3 2.90 0.53 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24867 BP_3 6.00 5.51 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24868 BP_3 12.07 1.40 707 478252125 ENN72556.1 240 6.8e-18 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 157 1.2e-09 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.24869 BP_3 2.00 6.79 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2487 BP_3 4.00 0.48 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24870 BP_3 45.00 5.38 695 817061123 XP_012252151.1 207 4.5e-14 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00448//PF00004//PF00437 SRP54-type protein, GTPase domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006810//GO:0006614 transport//SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0005524 GTP binding//ATP binding -- -- -- -- Cluster-8309.24871 BP_3 10.00 3.37 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24872 BP_3 1.00 2.80 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24873 BP_3 124.71 1.16 5494 642930804 XP_008196097.1 3880 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: peregrin [Tribolium castaneum] 751215996 XM_011162629.1 112 1.37294e-48 PREDICTED: Solenopsis invicta peregrin-like (LOC105196610), partial mRNA K11348 BRPF1 bromodomain and PHD finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11348 O95696 1550 2.7e-170 Bromodomain-containing protein 1 OS=Homo sapiens GN=BRD1 PE=1 SV=1 PF00628//PF00439 PHD-finger//Bromodomain -- -- GO:0005515 protein binding -- -- KOG0955 PHD finger protein BR140/LIN-49 Cluster-8309.24874 BP_3 102.00 3.18 1838 642925828 XP_008190476.1 269 7.7e-21 PREDICTED: uncharacterized protein LOC103312202 isoform X1 [Tribolium castaneum]>gi|270008942|gb|EFA05390.1| hypothetical protein TcasGA2_TC015562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01920//PF03462//PF07926//PF05531//PF16326 Prefoldin subunit//PCRF domain//TPR/MLP1/MLP2-like protein//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain GO:0006449//GO:0006457//GO:0006606//GO:0006415 regulation of translational termination//protein folding//protein import into nucleus//translational termination GO:0016149//GO:0003677//GO:0051082 translation release factor activity, codon specific//DNA binding//unfolded protein binding GO:0019028//GO:0018444//GO:0005737//GO:0016272//GO:0005840 viral capsid//translation release factor complex//cytoplasm//prefoldin complex//ribosome -- -- Cluster-8309.24875 BP_3 112.04 0.99 5737 642930804 XP_008196097.1 3880 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: peregrin [Tribolium castaneum] 751215996 XM_011162629.1 112 1.43406e-48 PREDICTED: Solenopsis invicta peregrin-like (LOC105196610), partial mRNA K11348 BRPF1 bromodomain and PHD finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11348 O95696 1550 2.8e-170 Bromodomain-containing protein 1 OS=Homo sapiens GN=BRD1 PE=1 SV=1 PF00628//PF00439 PHD-finger//Bromodomain -- -- GO:0005515 protein binding -- -- KOG0955 PHD finger protein BR140/LIN-49 Cluster-8309.24876 BP_3 519.91 4.83 5483 642930804 XP_008196097.1 3880 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: peregrin [Tribolium castaneum] 751215996 XM_011162629.1 112 1.37017e-48 PREDICTED: Solenopsis invicta peregrin-like (LOC105196610), partial mRNA K11348 BRPF1 bromodomain and PHD finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11348 O95696 1550 2.7e-170 Bromodomain-containing protein 1 OS=Homo sapiens GN=BRD1 PE=1 SV=1 PF00439//PF00628 Bromodomain//PHD-finger -- -- GO:0005515 protein binding -- -- KOG0955 PHD finger protein BR140/LIN-49 Cluster-8309.24877 BP_3 108.39 1.02 5398 642930804 XP_008196097.1 3880 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: peregrin [Tribolium castaneum] 751215996 XM_011162629.1 112 1.34879e-48 PREDICTED: Solenopsis invicta peregrin-like (LOC105196610), partial mRNA K11348 BRPF1 bromodomain and PHD finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11348 O95696 1550 2.7e-170 Bromodomain-containing protein 1 OS=Homo sapiens GN=BRD1 PE=1 SV=1 PF00628//PF00439 PHD-finger//Bromodomain -- -- GO:0005515 protein binding -- -- KOG0955 PHD finger protein BR140/LIN-49 Cluster-8309.24878 BP_3 15.82 0.32 2671 642910368 XP_001810974.2 2537 1.1e-283 PREDICTED: kinesin-like protein KIF12 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D2Z8 777 5.7e-81 Kinesin-like protein KIF12 OS=Mus musculus GN=Kif12 PE=2 SV=1 PF00170//PF02183//PF00225 bZIP transcription factor//Homeobox associated leucine zipper//Kinesin motor domain GO:0006355//GO:0007017//GO:0007018 regulation of transcription, DNA-templated//microtubule-based process//microtubule-based movement GO:0008017//GO:0043565//GO:0003700//GO:0005524//GO:0003777 microtubule binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874//GO:0005667 tubulin complex//microtubule//transcription factor complex KOG4280 Kinesin-like protein Cluster-8309.24880 BP_3 28.00 1.94 987 332373724 AEE62003.1 982 8.7e-104 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q60477 456 3.5e-44 Cysteine-rich secretory protein 2 OS=Cavia porcellus GN=CRISP2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24881 BP_3 805.41 44.76 1159 478262391 ENN81062.1 221 1.8e-15 hypothetical protein YQE_02431, partial [Dendroctonus ponderosae]>gi|546673611|gb|ERL85175.1| hypothetical protein D910_02597 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09830 ATP adenylyltransferase GO:0006144 purine nucleobase metabolic process GO:0003877 ATP adenylyltransferase activity -- -- -- -- Cluster-8309.24882 BP_3 9.59 0.45 1328 478262391 ENN81062.1 216 7.7e-15 hypothetical protein YQE_02431, partial [Dendroctonus ponderosae]>gi|546673611|gb|ERL85175.1| hypothetical protein D910_02597 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09830 ATP adenylyltransferase GO:0006144 purine nucleobase metabolic process GO:0003877 ATP adenylyltransferase activity -- -- -- -- Cluster-8309.24883 BP_3 60.32 1.17 2777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01342 SAND domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.24887 BP_3 262.04 5.67 2519 642928838 XP_008195583.1 3456 0.0e+00 PREDICTED: uncharacterized protein LOC656400 [Tribolium castaneum] 642928837 XM_008197361.1 669 0 PREDICTED: Tribolium castaneum uncharacterized LOC656400 (LOC656400), mRNA -- -- -- -- Q8C8H8 337 5.6e-30 Kyphoscoliosis peptidase OS=Mus musculus GN=Ky PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.24889 BP_3 7.00 4.01 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24891 BP_3 252.01 3.93 3386 642931832 XP_008196749.1 2114 1.6e-234 PREDICTED: GPI inositol-deacylase [Tribolium castaneum]>gi|270011727|gb|EFA08175.1| hypothetical protein TcasGA2_TC005802 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q75T13 826 1.5e-86 GPI inositol-deacylase OS=Homo sapiens GN=PGAP1 PE=1 SV=1 PF07074//PF01764//PF07819 Translocon-associated protein, gamma subunit (TRAP-gamma)//Lipase (class 3)//PGAP1-like protein GO:0009987//GO:0006886//GO:0006629//GO:0006613//GO:0006505 cellular process//intracellular protein transport//lipid metabolic process//cotranslational protein targeting to membrane//GPI anchor metabolic process GO:0016788 hydrolase activity, acting on ester bonds GO:0005784//GO:0030176 Sec61 translocon complex//integral component of endoplasmic reticulum membrane KOG3724 Negative regulator of COPII vesicle formation Cluster-8309.24892 BP_3 421.04 7.08 3159 91089165 XP_973951.1 493 1.4e-46 PREDICTED: H/ACA ribonucleoprotein complex non-core subunit NAF1 [Tribolium castaneum]>gi|270011488|gb|EFA07936.1| hypothetical protein TcasGA2_TC005517 [Tribolium castaneum] -- -- -- -- -- K14763 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 http://www.genome.jp/dbget-bin/www_bget?ko:K14763 Q9VJ62 316 1.9e-27 H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Drosophila melanogaster GN=CG10341 PE=1 SV=2 PF04889//PF04410 Cwf15/Cwc15 cell cycle control protein//Gar1/Naf1 RNA binding region GO:0000398//GO:0042254//GO:0001522 mRNA splicing, via spliceosome//ribosome biogenesis//pseudouridine synthesis -- -- GO:0005681 spliceosomal complex KOG2236 Uncharacterized conserved protein Cluster-8309.24896 BP_3 532.68 9.09 3117 642933797 XP_008197328.1 3837 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q8CG09 2264 2.5e-253 Multidrug resistance-associated protein 1 OS=Rattus norvegicus GN=Abcc1 PE=1 SV=2 PF00437//PF00005//PF17001//PF03193//PF00664//PF13304//PF01926 Type II/IV secretion system protein//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0009306//GO:0006810//GO:0055085 protein secretion//transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24897 BP_3 23.27 0.37 3323 642933785 XP_008197283.1 1953 7.4e-216 PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933787|ref|XP_008197292.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933789|ref|XP_008197304.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 1215 1.2e-131 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF01637//PF09547//PF00005//PF01120//PF17001//PF03193//PF00664//PF13304//PF01926 Archaeal ATPase//Stage IV sporulation protein A (spore_IV_A)//ABC transporter//Alpha-L-fucosidase//Type III secretion basal body protein I, YscI, HrpB, PscI//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0055085//GO:0009306//GO:0006810//GO:0043934//GO:0005975 transmembrane transport//protein secretion//transport//sporulation//carbohydrate metabolic process GO:0005524//GO:0004560//GO:0003924//GO:0005525//GO:0016887//GO:0042626 ATP binding//alpha-L-fucosidase activity//GTPase activity//GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24898 BP_3 147.09 2.23 3477 478260834 ENN80486.1 1767 2.9e-194 hypothetical protein YQE_03090, partial [Dendroctonus ponderosae] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 1522 3.0e-167 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF01926//PF13304//PF00664//PF03193//PF00005 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24899 BP_3 165.00 15.83 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.249 BP_3 2.00 0.38 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2490 BP_3 30.00 0.76 2192 225382096 ACN89260.1 2005 4.6e-222 protein disulfide isomerase [Litopenaeus vannamei] 338224486 HM217893.1 387 0 Scylla paramamosain calsequestrin-1 precursor, mRNA, partial cds K09580 PDIA1, P4HB protein disulfide-isomerase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K09580 P54399 1497 1.5e-164 Protein disulfide-isomerase OS=Drosophila melanogaster GN=Pdi PE=2 SV=1 PF00462//PF00578//PF00085//PF08534//PF01216//PF07912 Glutaredoxin//AhpC/TSA family//Thioredoxin//Redoxin//Calsequestrin//ERp29, N-terminal domain GO:0006118//GO:0045454//GO:0055114//GO:0009306 obsolete electron transport//cell redox homeostasis//oxidation-reduction process//protein secretion GO:0015035//GO:0016209//GO:0005509//GO:0009055//GO:0016491 protein disulfide oxidoreductase activity//antioxidant activity//calcium ion binding//electron carrier activity//oxidoreductase activity GO:0005788 endoplasmic reticulum lumen KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.24900 BP_3 150.00 3.56 2324 270002785 EEZ99232.1 503 7.1e-48 brinker [Tribolium castaneum] 642913018 XM_001815577.2 47 7.8289e-13 PREDICTED: Tribolium castaneum uncharacterized LOC100142498 (LOC100142498), mRNA -- -- -- -- -- -- -- -- PF00253//PF04218//PF01527//PF01381//PF04145//PF02954 Ribosomal protein S14p/S29e//CENP-B N-terminal DNA-binding domain//Transposase//Helix-turn-helix//Ctr copper transporter family//Bacterial regulatory protein, Fis family GO:0042254//GO:0035434//GO:0006412//GO:0006313//GO:0006825 ribosome biogenesis//copper ion transmembrane transport//translation//transposition, DNA-mediated//copper ion transport GO:0004803//GO:0005375//GO:0003735//GO:0043565//GO:0003677 transposase activity//copper ion transmembrane transporter activity//structural constituent of ribosome//sequence-specific DNA binding//DNA binding GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane -- -- Cluster-8309.24901 BP_3 6.00 0.33 1176 642928718 XP_008199753.1 1287 4.4e-139 PREDICTED: fatty acid 2-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2LAM0 658 1.6e-67 Fatty acid 2-hydroxylase OS=Rattus norvegicus GN=Fa2h PE=1 SV=2 PF12822//PF04116 Protein of unknown function (DUF3816)//Fatty acid hydroxylase superfamily GO:0055114//GO:0006810//GO:0006633 oxidation-reduction process//transport//fatty acid biosynthetic process GO:0005215//GO:0016491//GO:0005506 transporter activity//oxidoreductase activity//iron ion binding -- -- KOG0539 Sphingolipid fatty acid hydroxylase Cluster-8309.24902 BP_3 15.60 0.58 1598 642913362 XP_008195422.1 233 1.0e-16 PREDICTED: uncharacterized protein LOC103313584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24904 BP_3 16.00 1.20 937 123507540 XP_001329437.1 251 4.8e-19 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121912392|gb|EAY17214.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15503 ANKRD44 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K15503 Q4UMH6 225 2.0e-17 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF05396//PF13606//PF00023 Phage T7 capsid assembly protein//Ankyrin repeat//Ankyrin repeat GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- -- -- Cluster-8309.24905 BP_3 56.43 4.11 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24908 BP_3 117.00 3.40 1949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01983//PF01063 Guanylyl transferase CofC like//Amino-transferase class IV GO:0008152 metabolic process GO:0016779//GO:0003824 nucleotidyltransferase activity//catalytic activity -- -- -- -- Cluster-8309.2491 BP_3 992.00 44.72 1361 478250584 ENN71076.1 998 1.7e-105 hypothetical protein YQE_12010, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9GP81 377 7.0e-35 Protein yellow OS=Drosophila guanche GN=y PE=3 SV=1 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.24911 BP_3 1982.03 154.02 912 125629055 CAL23192.2 278 3.4e-22 gustatory receptor candidate 59 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24913 BP_3 68.85 2.19 1804 86515328 NP_001034489.1 2103 1.6e-233 homothorax [Tribolium castaneum]>gi|38490517|emb|CAD57735.1| homothorax [Tribolium castaneum]>gi|270010957|gb|EFA07405.1| hypothetical protein TcasGA2_TC008629 [Tribolium castaneum] 642930025 XM_008197995.1 420 0 PREDICTED: Tribolium castaneum homothorax (Hth), transcript variant X1, mRNA K16672 HTH homeobox protein homothorax http://www.genome.jp/dbget-bin/www_bget?ko:K16672 O46339 1303 3.9e-142 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.24916 BP_3 1024.58 26.15 2180 189236353 XP_001807129.1 2395 2.7e-267 PREDICTED: signal recognition particle receptor subunit alpha homolog [Tribolium castaneum]>gi|270005877|gb|EFA02325.1| hypothetical protein TcasGA2_TC007993 [Tribolium castaneum] 720030593 XM_010267260.1 42 4.41537e-10 PREDICTED: Nelumbo nucifera signal recognition particle receptor subunit alpha-like (LOC104603264), transcript variant X4, mRNA K13431 SRPR signal recognition particle receptor subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13431 Q9U5L1 1446 1.2e-158 Signal recognition particle receptor subunit alpha homolog OS=Drosophila melanogaster GN=Gtp-bp PE=1 SV=2 PF00448//PF02881//PF04086//PF01926//PF03266 SRP54-type protein, GTPase domain//SRP54-type protein, helical bundle domain//Signal recognition particle, alpha subunit, N-terminal//50S ribosome-binding GTPase//NTPase GO:0006614//GO:0006886//GO:0006184 SRP-dependent cotranslational protein targeting to membrane//intracellular protein transport//obsolete GTP catabolic process GO:0098519//GO:0003924//GO:0005047//GO:0005525 nucleotide phosphatase activity, acting on free nucleotides//GTPase activity//signal recognition particle binding//GTP binding GO:0005786//GO:0005785 signal recognition particle, endoplasmic reticulum targeting//signal recognition particle receptor complex KOG0781 Signal recognition particle receptor, alpha subunit Cluster-8309.24918 BP_3 912.78 8.87 5249 270015427 EFA11875.1 4216 0.0e+00 hypothetical protein TcasGA2_TC004289 [Tribolium castaneum] 642939802 XM_008195501.1 487 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase 69D (LOC659057), mRNA K01104 E3.1.3.48 protein-tyrosine phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01104 P16620 1984 1.2e-220 Tyrosine-protein phosphatase 69D OS=Drosophila melanogaster GN=Ptp69D PE=1 SV=2 PF00102//PF16656//PF00041//PF13895//PF01108//PF00782 Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//Tissue factor//Dual specificity phosphatase, catalytic domain GO:0006771//GO:0006570//GO:0006470//GO:0019497 riboflavin metabolic process//tyrosine metabolic process//protein dephosphorylation//hexachlorocyclohexane metabolic process GO:0046872//GO:0003993//GO:0008138//GO:0005515//GO:0004725 metal ion binding//acid phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.24919 BP_3 328.22 3.24 5180 270015427 EFA11875.1 4216 0.0e+00 hypothetical protein TcasGA2_TC004289 [Tribolium castaneum] 642939802 XM_008195501.1 487 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase 69D (LOC659057), mRNA K01104 E3.1.3.48 protein-tyrosine phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01104 P16620 1984 1.2e-220 Tyrosine-protein phosphatase 69D OS=Drosophila melanogaster GN=Ptp69D PE=1 SV=2 PF00782//PF01108//PF13895//PF00041//PF16656//PF00102 Dual specificity phosphatase, catalytic domain//Tissue factor//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Protein-tyrosine phosphatase GO:0006771//GO:0006570//GO:0006470//GO:0019497 riboflavin metabolic process//tyrosine metabolic process//protein dephosphorylation//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0008138//GO:0005515//GO:0004725 acid phosphatase activity//metal ion binding//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.24920 BP_3 1.00 1.05 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24921 BP_3 20.00 0.81 1485 546682551 ERL92474.1 957 1.0e-100 hypothetical protein D910_09787 [Dendroctonus ponderosae] -- -- -- -- -- K15442 TAD3, ADAT3 tRNA-specific adenosine deaminase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15442 Q8JFW4 445 1.0e-42 Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Danio rerio GN=adat3 PE=2 SV=2 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region -- -- GO:0008270 zinc ion binding -- -- KOG2771 Subunit of tRNA-specific adenosine-34 deaminase Cluster-8309.24924 BP_3 122.00 0.65 9279 270015258 EFA11706.1 1252 4.0e-134 hypothetical protein TcasGA2_TC001793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 637 3.4e-64 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF09668//PF13683//PF00098//PF00665 Aspartyl protease//Integrase core domain//Zinc knuckle//Integrase core domain GO:0006508//GO:0015074 proteolysis//DNA integration GO:0003676//GO:0004190//GO:0008270 nucleic acid binding//aspartic-type endopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.24926 BP_3 2.00 0.53 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00647 Elongation factor 1 gamma, conserved domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840 ribosome -- -- Cluster-8309.24929 BP_3 297.66 3.45 4456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2493 BP_3 2.00 4.91 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24932 BP_3 446.24 7.11 3318 642919196 XP_008191777.1 1380 2.1e-149 PREDICTED: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [Tribolium castaneum] -- -- -- -- -- K01001 ALG7 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01001 Q9H3H5 694 3.0e-71 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase OS=Homo sapiens GN=DPAGT1 PE=1 SV=2 PF04724//PF04410//PF00953//PF02706 Glycosyltransferase family 17//Gar1/Naf1 RNA binding region//Glycosyl transferase family 4//Chain length determinant protein GO:0009103//GO:0006487//GO:0006629//GO:0042254//GO:0001522//GO:0009252 lipopolysaccharide biosynthetic process//protein N-linked glycosylation//lipid metabolic process//ribosome biogenesis//pseudouridine synthesis//peptidoglycan biosynthetic process GO:0008963//GO:0003830 phospho-N-acetylmuramoyl-pentapeptide-transferase activity//beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2788 Glycosyltransferase Cluster-8309.24935 BP_3 606.50 7.35 4270 642912951 XP_008201321.1 1057 7.5e-112 PREDICTED: uncharacterized protein LOC103315151 isoform X2 [Tribolium castaneum] -- -- -- -- -- K18407 TDRD5 tudor domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18407 Q4R3G4 152 2.7e-08 RING finger protein 17 OS=Macaca fascicularis GN=RNF17 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24937 BP_3 111.18 5.11 1341 642916731 XP_008192389.1 555 3.8e-54 PREDICTED: uncharacterized protein LOC103312734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24939 BP_3 45.36 0.51 4571 642910521 XP_008200247.1 918 1.1e-95 PREDICTED: muscle M-line assembly protein unc-89-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2494 BP_3 282.45 37.47 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24940 BP_3 178.67 2.01 4567 642910521 XP_008200247.1 918 1.1e-95 PREDICTED: muscle M-line assembly protein unc-89-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24942 BP_3 133.02 2.54 2818 546684003 ERL93732.1 2078 2.0e-230 hypothetical protein D910_11018 [Dendroctonus ponderosae] 642929691 XM_970420.3 420 0 PREDICTED: Tribolium castaneum splicing factor 3B subunit 2 (LOC664413), transcript variant X2, mRNA K12829 SF3B2, SAP145, CUS1 splicing factor 3B subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12829 Q13435 1529 3.8e-168 Splicing factor 3B subunit 2 OS=Homo sapiens GN=SF3B2 PE=1 SV=2 PF04998//PF04037 RNA polymerase Rpb1, domain 5//Domain of unknown function (DUF382) GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus KOG2330 Splicing factor 3b, subunit 2 Cluster-8309.24943 BP_3 26.22 0.50 2828 642934423 XP_008197655.1 180 2.5e-10 PREDICTED: WAS/WASL-interacting protein family member 2 isoform X1 [Tribolium castaneum]>gi|642934425|ref|XP_008197656.1| PREDICTED: WAS/WASL-interacting protein family member 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205//PF01213 WH2 motif//Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.24944 BP_3 81.53 2.39 1934 546673062 ERL84739.1 834 2.5e-86 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 389 4.0e-36 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF01764//PF10503//PF07859//PF02230//PF11112 Lipase (class 3)//Esterase PHB depolymerase//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Pyocin activator protein PrtN GO:0006629//GO:0006355//GO:0008152 lipid metabolic process//regulation of transcription, DNA-templated//metabolic process GO:0016787 hydrolase activity GO:0005576 extracellular region KOG1552 Predicted alpha/beta hydrolase Cluster-8309.24945 BP_3 9.00 1.59 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24947 BP_3 18.19 3.72 527 91085843 XP_974961.1 163 4.3e-09 PREDICTED: protein lunapark [Tribolium castaneum]>gi|270010140|gb|EFA06588.1| hypothetical protein TcasGA2_TC009502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24949 BP_3 3.82 0.45 698 531450771 AGT57862.1 376 1.1e-33 cytochrome P450 347c1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964R1 240 2.8e-19 Cytochrome P450 6j1 OS=Blattella germanica GN=CYP6J1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.2495 BP_3 14.00 0.84 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14098 Small, acid-soluble spore protein I GO:0030436 asexual sporulation -- -- -- -- -- -- Cluster-8309.24958 BP_3 12.85 0.36 1990 546672990 ERL84684.1 1209 8.3e-130 hypothetical protein D910_02111 [Dendroctonus ponderosae] 820858830 XM_003696915.2 86 1.39708e-34 PREDICTED: Apis florea pyruvate dehydrogenase E1 component subunit beta, mitochondrial (LOC100863907), mRNA K00162 PDHB, pdhB pyruvate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00162 O44451 997 1.3e-106 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Caenorhabditis elegans GN=pdhb-1 PE=1 SV=2 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.24959 BP_3 29.00 0.44 3439 642917388 XP_008199670.1 586 2.5e-57 PREDICTED: slit homolog 1 protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TF66 218 4.8e-16 Leucine-rich repeat-containing protein 15 OS=Homo sapiens GN=LRRC15 PE=2 SV=2 PF07062//PF13855//PF00560 Clc-like//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.24960 BP_3 26.18 0.36 3776 91077034 XP_967567.1 1173 2.4e-125 PREDICTED: cysteine and histidine-rich domain-containing protein [Tribolium castaneum]>gi|270001750|gb|EEZ98197.1| hypothetical protein TcasGA2_TC000627 [Tribolium castaneum] -- -- -- -- -- K16729 CHORDC1, CHP1 cysteine and histidine-rich domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16729 Q9VCC0 980 2.3e-104 Cysteine and histidine-rich domain-containing protein OS=Drosophila melanogaster GN=CHORD PE=1 SV=1 PF00779//PF01082//PF03473 BTK motif//Copper type II ascorbate-dependent monooxygenase, N-terminal domain//MOSC domain GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0016715//GO:0030151//GO:0004497//GO:0030170//GO:0005507//GO:0003824 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//molybdenum ion binding//monooxygenase activity//pyridoxal phosphate binding//copper ion binding//catalytic activity -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.24961 BP_3 97.39 3.08 1818 91077034 XP_967567.1 1173 1.1e-125 PREDICTED: cysteine and histidine-rich domain-containing protein [Tribolium castaneum]>gi|270001750|gb|EEZ98197.1| hypothetical protein TcasGA2_TC000627 [Tribolium castaneum] -- -- -- -- -- K16729 CHORDC1, CHP1 cysteine and histidine-rich domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16729 Q9VCC0 980 1.1e-104 Cysteine and histidine-rich domain-containing protein OS=Drosophila melanogaster GN=CHORD PE=1 SV=1 PF00779//PF03473 BTK motif//MOSC domain GO:0035556 intracellular signal transduction GO:0030151//GO:0030170//GO:0003824 molybdenum ion binding//pyridoxal phosphate binding//catalytic activity -- -- KOG1667 Zn2+-binding protein Melusin/RAR1, contains CHORD domain Cluster-8309.24962 BP_3 15.23 0.40 2126 91087553 XP_970739.1 1266 2.2e-136 PREDICTED: protein farnesyltransferase subunit beta [Tribolium castaneum]>gi|270010683|gb|EFA07131.1| hypothetical protein TcasGA2_TC010122 [Tribolium castaneum] 56758975 AY815896.1 42 4.30421e-10 Schistosoma japonicum SJCHGC09483 protein mRNA, complete cds K05954 FNTB protein farnesyltransferase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K05954 P49356 974 6.5e-104 Protein farnesyltransferase subunit beta OS=Homo sapiens GN=FNTB PE=1 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat GO:0018343//GO:0042127 protein farnesylation//regulation of cell proliferation GO:0003824 catalytic activity GO:0005965 protein farnesyltransferase complex KOG0365 Beta subunit of farnesyltransferase Cluster-8309.24964 BP_3 3.00 0.37 679 91089745 XP_975162.1 179 7.7e-11 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q57886 126 4.4e-06 RIO-type serine/threonine-protein kinase Rio1 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) GN=rio1 PE=3 SV=1 -- -- GO:0008152//GO:0009069//GO:0016310 metabolic process//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674 ATP binding//protein serine/threonine kinase activity -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.24965 BP_3 3.85 0.42 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24966 BP_3 21.92 2.16 780 642939055 XP_008200202.1 250 5.2e-19 PREDICTED: uncharacterized protein LOC103314863 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24967 BP_3 5.00 3.65 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24969 BP_3 148.03 1.83 4189 642934045 XP_008197618.1 1044 2.4e-110 PREDICTED: kelch-like protein 38 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 232 1.4e-17 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF01344//PF13606//PF07646//PF00651//PF00023 Kelch motif//Ankyrin repeat//Kelch motif//BTB/POZ domain//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.2497 BP_3 25.12 0.73 1941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24974 BP_3 941.58 13.61 3626 478255515 ENN75732.1 1353 3.0e-146 hypothetical protein YQE_07692, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P97943 477 4.7e-46 Scavenger receptor class B member 1 OS=Rattus norvegicus GN=Scarb1 PE=1 SV=1 PF00089//PF01130 Trypsin//CD36 family GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.24977 BP_3 19.40 0.48 2255 642919312 XP_008191821.1 955 2.7e-100 PREDICTED: periodic tryptophan protein 1 homolog [Tribolium castaneum] 31222365 XM_317168.1 209 6.68504e-103 Anopheles gambiae str. PEST AGAP008298-PA (AgaP_AGAP008298) mRNA, complete cds K12859 TXNL4A, DIB1 U5 snRNP protein, DIM1 family http://www.genome.jp/dbget-bin/www_bget?ko:K12859 P83876 721 1.5e-74 Thioredoxin-like protein 4A OS=Homo sapiens GN=TXNL4A PE=1 SV=1 PF00085//PF02966//PF01346//PF00400 Thioredoxin//Mitosis protein DIM1//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//WD domain, G-beta repeat GO:0006457//GO:0000398//GO:0045454 protein folding//mRNA splicing, via spliceosome//cell redox homeostasis GO:0005515 protein binding GO:0005681 spliceosomal complex KOG0270 WD40 repeat-containing protein Cluster-8309.24979 BP_3 175.22 1.34 6615 91082903 XP_972273.1 1150 1.9e-122 PREDICTED: uncharacterized protein LOC660988 isoform X1 [Tribolium castaneum]>gi|270007611|gb|EFA04059.1| hypothetical protein TcasGA2_TC014292 [Tribolium castaneum] -- -- -- -- -- K16731 GOLGA1 golgin subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16731 Q92805 295 1.1e-24 Golgin subfamily A member 1 OS=Homo sapiens GN=GOLGA1 PE=1 SV=3 PF06273//PF09497//PF04871//PF04111//PF06156//PF10018//PF08988//PF01166//PF06810//PF08066//PF01496//PF05529//PF05929//PF00038//PF02601//PF08702//PF01465//PF05837 Plant specific eukaryotic initiation factor 4B//Transcription mediator complex subunit Med12//Uso1 / p115 like vesicle tethering protein, C terminal region//Autophagy protein Apg6//Protein of unknown function (DUF972)//Vitamin-D-receptor interacting Mediator subunit 4//Type III secretion system, cytoplasmic E component of needle//TSC-22/dip/bun family//Phage minor structural protein GP20//PMC2NT (NUC016) domain//V-type ATPase 116kDa subunit family//B-cell receptor-associated protein 31-like//Phage capsid scaffolding protein (GPO) serine peptidase//Intermediate filament protein//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//GRIP domain//Centromere protein H (CENP-H) GO:0015991//GO:0019069//GO:0006308//GO:0000042//GO:0051258//GO:0006914//GO:0006886//GO:0007165//GO:0009405//GO:0015031//GO:0006355//GO:0006446//GO:0030168//GO:0051382//GO:0015992//GO:0006396//GO:0006357//GO:0006260 ATP hydrolysis coupled proton transport//viral capsid assembly//DNA catabolic process//protein targeting to Golgi//protein polymerization//autophagy//intracellular protein transport//signal transduction//pathogenesis//protein transport//regulation of transcription, DNA-templated//regulation of translational initiation//platelet activation//kinetochore assembly//proton transport//RNA processing//regulation of transcription from RNA polymerase II promoter//DNA replication GO:0008855//GO:0005515//GO:0005198//GO:0015078//GO:0008565//GO:0001104//GO:0030674//GO:0003743//GO:0003700//GO:0005102 exodeoxyribonuclease VII activity//protein binding//structural molecule activity//hydrogen ion transmembrane transporter activity//protein transporter activity//RNA polymerase II transcription cofactor activity//protein binding, bridging//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//receptor binding GO:0000176//GO:0005783//GO:0033179//GO:0016020//GO:0016021//GO:0005737//GO:0005840//GO:0005667//GO:0016592//GO:0000776//GO:0005882//GO:0005577//GO:0009318 nuclear exosome (RNase complex)//endoplasmic reticulum//proton-transporting V-type ATPase, V0 domain//membrane//integral component of membrane//cytoplasm//ribosome//transcription factor complex//mediator complex//kinetochore//intermediate filament//fibrinogen complex//exodeoxyribonuclease VII complex -- -- Cluster-8309.24981 BP_3 308.29 3.21 4915 91082903 XP_972273.1 1219 1.4e-130 PREDICTED: uncharacterized protein LOC660988 isoform X1 [Tribolium castaneum]>gi|270007611|gb|EFA04059.1| hypothetical protein TcasGA2_TC014292 [Tribolium castaneum] -- -- -- -- -- K16731 GOLGA1 golgin subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16731 Q92805 295 8.2e-25 Golgin subfamily A member 1 OS=Homo sapiens GN=GOLGA1 PE=1 SV=3 PF01166//PF05837//PF08988//PF01465//PF10018//PF08702//PF02601//PF06156//PF04111//PF05929//PF04871//PF08066//PF09497//PF06273 TSC-22/dip/bun family//Centromere protein H (CENP-H)//Type III secretion system, cytoplasmic E component of needle//GRIP domain//Vitamin-D-receptor interacting Mediator subunit 4//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Protein of unknown function (DUF972)//Autophagy protein Apg6//Phage capsid scaffolding protein (GPO) serine peptidase//Uso1 / p115 like vesicle tethering protein, C terminal region//PMC2NT (NUC016) domain//Transcription mediator complex subunit Med12//Plant specific eukaryotic initiation factor 4B GO:0015031//GO:0006355//GO:0051258//GO:0006914//GO:0006886//GO:0009405//GO:0007165//GO:0019069//GO:0006308//GO:0000042//GO:0006396//GO:0006357//GO:0006260//GO:0051382//GO:0030168//GO:0006446 protein transport//regulation of transcription, DNA-templated//protein polymerization//autophagy//intracellular protein transport//pathogenesis//signal transduction//viral capsid assembly//DNA catabolic process//protein targeting to Golgi//RNA processing//regulation of transcription from RNA polymerase II promoter//DNA replication//kinetochore assembly//platelet activation//regulation of translational initiation GO:0008565//GO:0008855//GO:0005515//GO:0003700//GO:0005102//GO:0003743//GO:0030674//GO:0001104 protein transporter activity//exodeoxyribonuclease VII activity//protein binding//transcription factor activity, sequence-specific DNA binding//receptor binding//translation initiation factor activity//protein binding, bridging//RNA polymerase II transcription cofactor activity GO:0005737//GO:0005840//GO:0016020//GO:0000176//GO:0005577//GO:0009318//GO:0000776//GO:0005667//GO:0016592 cytoplasm//ribosome//membrane//nuclear exosome (RNase complex)//fibrinogen complex//exodeoxyribonuclease VII complex//kinetochore//transcription factor complex//mediator complex -- -- Cluster-8309.24982 BP_3 49.77 0.45 5637 642914898 XP_008190435.1 5972 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2877 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.24987 BP_3 18.08 1.50 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24988 BP_3 339.18 6.67 2742 642925940 XP_008194704.1 1419 5.1e-154 PREDICTED: alpha-1D adrenergic receptor [Tribolium castaneum]>gi|270009238|gb|EFA05686.1| hypothetical protein TcasGA2_TC015120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TTM9 138 7.3e-07 Alpha-1D adrenergic receptor OS=Sus scrofa GN=ADRA1D PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.24989 BP_3 133.33 0.98 6876 546675629 ERL86779.1 7341 0.0e+00 hypothetical protein D910_04185 [Dendroctonus ponderosae] 705688754 XM_010123154.1 36 3.04538e-06 PREDICTED: Chlamydotis macqueenii activating signal cointegrator 1 complex subunit 3 (ASCC3), partial mRNA K18663 ASCC3 activating signal cointegrator complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18663 F1NTD6 3950 0.0e+00 Activating signal cointegrator 1 complex subunit 3 OS=Gallus gallus GN=ascc3 PE=3 SV=2 PF02562//PF00098//PF04851//PF00176//PF03051//PF00580//PF00270 PhoH-like protein//Zinc knuckle//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//Peptidase C1-like family//UvrD/REP helicase N-terminal domain//DEAD/DEAH box helicase GO:0006508 proteolysis GO:0005524//GO:0008270//GO:0016787//GO:0003677//GO:0003676//GO:0004197 ATP binding//zinc ion binding//hydrolase activity//DNA binding//nucleic acid binding//cysteine-type endopeptidase activity -- -- KOG0952 DNA/RNA helicase MER3/SLH1, DEAD-box superfamily Cluster-8309.24990 BP_3 4.00 0.80 533 817061123 XP_012252151.1 148 2.4e-07 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.24992 BP_3 506.05 7.79 3424 546671730 ERL83919.1 584 4.3e-57 hypothetical protein D910_01211 [Dendroctonus ponderosae]>gi|546677087|gb|ERL87993.1| hypothetical protein D910_05382 [Dendroctonus ponderosae] -- -- -- -- -- K03122 TFIIA1, GTF2A1, TOA1 transcription initiation factor TFIIA large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03122 P52654 196 1.7e-13 Transcription initiation factor IIA subunit 1 OS=Drosophila melanogaster GN=TfIIA-L PE=1 SV=2 PF05365//PF03153//PF02535 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Transcription factor IIA, alpha/beta subunit//ZIP Zinc transporter GO:0006367//GO:0055085//GO:0006122//GO:0030001 transcription initiation from RNA polymerase II promoter//transmembrane transport//mitochondrial electron transport, ubiquinol to cytochrome c//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005672//GO:0005743//GO:0005750 membrane//transcription factor TFIIA complex//mitochondrial inner membrane//mitochondrial respiratory chain complex III KOG2652 RNA polymerase II transcription initiation factor TFIIA, large chain Cluster-8309.24993 BP_3 3.00 16.09 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07123 Photosystem II reaction centre W protein (PsbW) GO:0015979 photosynthesis -- -- GO:0009507//GO:0009523 chloroplast//photosystem II -- -- Cluster-8309.24994 BP_3 738.71 10.91 3556 642932215 XP_008194626.1 1886 4.7e-208 PREDICTED: protein spinster isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GQQ0 1341 3.0e-146 Protein spinster OS=Drosophila melanogaster GN=spin PE=1 SV=1 PF00083//PF03137//PF07690 Sugar (and other) transporter//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1330 Sugar transporter/spinster transmembrane protein Cluster-8309.24996 BP_3 1326.60 19.13 3634 642932215 XP_008194626.1 1851 5.5e-204 PREDICTED: protein spinster isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GQQ0 1391 4.9e-152 Protein spinster OS=Drosophila melanogaster GN=spin PE=1 SV=1 PF00335//PF00083//PF07690//PF03137 Tetraspanin family//Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1330 Sugar transporter/spinster transmembrane protein Cluster-8309.2500 BP_3 2.00 0.86 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25001 BP_3 122.38 2.07 3148 642936917 XP_008194457.1 672 2.4e-67 PREDICTED: uncharacterized protein LOC103313294 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13516//PF12937//PF00646 Leucine Rich repeat//F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25004 BP_3 48.46 0.80 3196 642936917 XP_008194457.1 656 1.8e-65 PREDICTED: uncharacterized protein LOC103313294 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF15966//PF13516//PF12937 F-box domain//F-box//Leucine Rich repeat//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25008 BP_3 351.00 44.37 673 478251326 ENN71794.1 228 1.6e-16 hypothetical protein YQE_11528, partial [Dendroctonus ponderosae]>gi|546685642|gb|ERL95114.1| hypothetical protein D910_12384 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08133 Anticodon nuclease activator family GO:0050792 regulation of viral process GO:0004518 nuclease activity -- -- -- -- Cluster-8309.25009 BP_3 20.61 1.47 969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2501 BP_3 991.30 92.01 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25010 BP_3 6.00 0.42 976 646710161 KDR15762.1 201 3.1e-13 Gamma-glutamyltranspeptidase 1 [Zootermopsis nevadensis] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 -- -- -- -- -- -- -- -- -- -- -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.25013 BP_3 228.37 12.77 1154 642926608 XP_969412.2 604 6.9e-60 PREDICTED: histone-lysine N-methyltransferase pr-set7 [Tribolium castaneum] -- -- -- -- -- K11428 SETD8 histone-lysine N-methyltransferase SETD8 http://www.genome.jp/dbget-bin/www_bget?ko:K11428 Q9VFK6 526 3.1e-52 Histone-lysine N-methyltransferase pr-set7 OS=Drosophila melanogaster GN=pr-set7 PE=1 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1085 Predicted methyltransferase (contains a SET domain) Cluster-8309.25014 BP_3 338.98 3.26 5297 642935051 XP_008199921.1 1091 1.1e-115 PREDICTED: cerebellar degeneration-related protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 333 3.4e-29 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF01025//PF02183//PF04977//PF06156//PF01057//PF10473 GrpE//Homeobox associated leucine zipper//Septum formation initiator//Protein of unknown function (DUF972)//Parvovirus non-structural protein NS1//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006457//GO:0019079//GO:0007049//GO:0006260//GO:0006355 protein folding//viral genome replication//cell cycle//DNA replication//regulation of transcription, DNA-templated GO:0045502//GO:0008134//GO:0003700//GO:0000774//GO:0043565//GO:0051087//GO:0042803 dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//sequence-specific DNA binding//chaperone binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.25016 BP_3 71.70 0.36 9982 91088841 XP_970807.1 2162 1.3e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.25477e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 5.7e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF01853//PF01160//PF06431//PF13508 MOZ/SAS family//Vertebrate endogenous opioids neuropeptide//Polyomavirus large T antigen C-terminus//Acetyltransferase (GNAT) domain GO:0006355//GO:0007218//GO:0006260//GO:0042967 regulation of transcription, DNA-templated//neuropeptide signaling pathway//DNA replication//acyl-carrier-protein biosynthetic process GO:0005488//GO:0016747//GO:0005524//GO:0003677//GO:0008080 binding//transferase activity, transferring acyl groups other than amino-acyl groups//ATP binding//DNA binding//N-acetyltransferase activity -- -- KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.25018 BP_3 19.00 0.79 1451 584482886 AHJ09940.1 900 4.1e-94 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- O93883 833 9.9e-88 Polygalacturonase OS=Penicillium griseoroseum GN=PGG1 PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0005975 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.25020 BP_3 689.04 9.25 3882 642931678 XP_008196684.1 193 1.1e-11 PREDICTED: neurofilament heavy polypeptide-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25021 BP_3 47.23 2.21 1322 478263026 ENN81426.1 1405 1.0e-152 hypothetical protein YQE_02120, partial [Dendroctonus ponderosae]>gi|546686068|gb|ERL95468.1| hypothetical protein D910_12730 [Dendroctonus ponderosae] 56251666 CR676700.2 57 1.21525e-18 Tetraodon nigroviridis full-length cDNA K10755 RFC2_4 replication factor C subunit 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10755 P53033 1165 2.9e-126 Replication factor C subunit 2 OS=Gallus gallus GN=RFC2 PE=2 SV=1 PF03266//PF07726//PF00005//PF00910//PF00270//PF05496//PF01443//PF07728//PF06144//PF00004 NTPase//ATPase family associated with various cellular activities (AAA)//ABC transporter//RNA helicase//DEAD/DEAH box helicase//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//AAA domain (dynein-related subfamily)//DNA polymerase III, delta subunit//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0006260//GO:0006281 DNA recombination//DNA replication//DNA repair GO:0003724//GO:0009378//GO:0003676//GO:0003887//GO:0003723//GO:0003677//GO:0016887//GO:0005524//GO:0098519 RNA helicase activity//four-way junction helicase activity//nucleic acid binding//DNA-directed DNA polymerase activity//RNA binding//DNA binding//ATPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides GO:0005657//GO:0042575//GO:0009379//GO:0009360 replication fork//DNA polymerase complex//Holliday junction helicase complex//DNA polymerase III complex KOG0991 Replication factor C, subunit RFC2 Cluster-8309.25022 BP_3 719.36 7.51 4911 642917526 XP_008191240.1 3541 0.0e+00 PREDICTED: WD repeat-containing protein 44 [Tribolium castaneum]>gi|642917528|ref|XP_008191241.1| PREDICTED: WD repeat-containing protein 44 [Tribolium castaneum]>gi|270003437|gb|EEZ99884.1| hypothetical protein TcasGA2_TC002668 [Tribolium castaneum] 815811139 XM_012371063.1 236 1.43672e-117 PREDICTED: Linepithema humile WD repeat-containing protein 44 (LOC105674607), mRNA -- -- -- -- Q6NVE8 1709 8.9e-189 WD repeat-containing protein 44 OS=Mus musculus GN=Wdr44 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0283 WD40 repeat-containing protein Cluster-8309.25025 BP_3 13.80 0.48 1673 332375674 AEE62978.1 290 2.6e-23 unknown [Dendroctonus ponderosae]>gi|478259141|gb|ENN79061.1| hypothetical protein YQE_04482, partial [Dendroctonus ponderosae]>gi|546684813|gb|ERL94395.1| hypothetical protein D910_11674 [Dendroctonus ponderosae] 242003302 XM_002422642.1 66 1.53577e-23 Pediculus humanus corporis histone deacetylase complex subunit SAP30, putative, mRNA K19202 SAP30 histone deacetylase complex subunit SAP30 http://www.genome.jp/dbget-bin/www_bget?ko:K19202 Q7PXY4 256 9.2e-21 Histone deacetylase complex subunit SAP30 homolog OS=Anopheles gambiae GN=AGAP001654 PE=3 SV=4 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25026 BP_3 3947.48 109.02 2037 91084815 XP_973232.1 1336 1.6e-144 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|642925910|ref|XP_008194692.1| PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008959|gb|EFA05407.1| hypothetical protein TcasGA2_TC015583 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 314 2.1e-27 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.25027 BP_3 37.52 1.63 1399 91084815 XP_973232.1 758 1.2e-77 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|642925910|ref|XP_008194692.1| PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008959|gb|EFA05407.1| hypothetical protein TcasGA2_TC015583 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.25030 BP_3 70.00 0.89 4080 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25033 BP_3 77.21 10.24 655 565318244 ETE69548.1 148 2.9e-07 Histone-lysine N-methyltransferase, H3 lysine-79 specific, partial [Ophiophagus hannah] -- -- -- -- -- -- -- -- -- Q8H0U8 138 1.7e-07 DEAD-box ATP-dependent RNA helicase 42 OS=Arabidopsis thaliana GN=RH42 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25034 BP_3 66.39 2.79 1439 642927776 XP_008195401.1 190 8.7e-12 PREDICTED: receptor-type tyrosine-protein phosphatase F-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25035 BP_3 19.64 0.31 3348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25037 BP_3 93.09 2.63 1999 91089769 XP_967094.1 1002 8.4e-106 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 B4MYA4 520 2.7e-51 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.25040 BP_3 142.42 4.54 1805 642928556 XP_008195374.1 1034 1.5e-109 PREDICTED: serine protease easter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 570 3.9e-57 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.25043 BP_3 18.92 0.31 3195 642921567 XP_008192427.1 2340 9.5e-261 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1235 5.3e-134 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF13181//PF00096//PF00515//PF13374//PF02891//PF06464//PF13176//PF00637 Tetratricopeptide repeat//Zinc finger, C2H2 type//Tetratricopeptide repeat//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//DMAP1-binding Domain//Tetratricopeptide repeat//Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008134//GO:0005515//GO:0008270//GO:0046872 transcription factor binding//protein binding//zinc ion binding//metal ion binding GO:0005634//GO:0005667//GO:0005622 nucleus//transcription factor complex//intracellular KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.25044 BP_3 53.09 0.97 2937 642921567 XP_008192427.1 2303 1.7e-256 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1083 2.1e-116 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF00637//PF00096//PF06464//PF02891//PF03854 Region in Clathrin and VPS//Zinc finger, C2H2 type//DMAP1-binding Domain//MIZ/SP-RING zinc finger//P-11 zinc finger GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0046872//GO:0008270//GO:0008134//GO:0003723 metal ion binding//zinc ion binding//transcription factor binding//RNA binding GO:0005622//GO:0005667//GO:0005634 intracellular//transcription factor complex//nucleus KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.25045 BP_3 779.11 14.46 2888 642921567 XP_008192427.1 3430 0.0e+00 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1665 6.6e-184 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF13181//PF02891//PF13374//PF00515//PF06464//PF13176//PF00637 Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat//Tetratricopeptide repeat//DMAP1-binding Domain//Tetratricopeptide repeat//Region in Clathrin and VPS GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0005515//GO:0008134 zinc ion binding//protein binding//transcription factor binding GO:0005622//GO:0005667//GO:0005634 intracellular//transcription factor complex//nucleus KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.2505 BP_3 427.75 227.56 380 546672298 ERL84225.1 339 1.2e-29 hypothetical protein D910_01603 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83995 255 2.7e-21 Cuticle protein 18.6, isoform B OS=Locusta migratoria PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25050 BP_3 69.00 0.49 7102 546682886 ERL92772.1 1026 4.9e-108 hypothetical protein D910_10080 [Dendroctonus ponderosae] 642934382 XM_962183.2 94 1.80193e-38 PREDICTED: Tribolium castaneum fibroblast growth factor receptor-like 1 (LOC655623), mRNA K15279 SLC35C1, FUCT1 solute carrier family 35 (GDP-fucose transporter), member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K15279 Q9VHT4 606 1.0e-60 GDP-fucose transporter 1 OS=Drosophila melanogaster GN=nac PE=1 SV=1 PF03030//PF00892 Inorganic H+ pyrophosphatase//EamA-like transporter family GO:0006119//GO:0015992 oxidative phosphorylation//proton transport GO:0009678//GO:0004427 hydrogen-translocating pyrophosphatase activity//inorganic diphosphatase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1442 GDP-fucose transporter Cluster-8309.25051 BP_3 31.74 2.10 1022 478256925 ENN77094.1 666 3.9e-67 hypothetical protein YQE_06429, partial [Dendroctonus ponderosae]>gi|546683033|gb|ERL92899.1| hypothetical protein D910_10204 [Dendroctonus ponderosae] -- -- -- -- -- K06963 TAN1, THUMPD1 tRNA acetyltransferase TAN1 http://www.genome.jp/dbget-bin/www_bget?ko:K06963 Q9VZD8 442 1.5e-42 THUMP domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG15014 PE=1 SV=2 PF03526//PF02926 Colicin E1 (microcin) immunity protein//THUMP domain GO:0030153//GO:0006955 bacteriocin immunity//immune response GO:0003723//GO:0015643 RNA binding//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.25053 BP_3 93.46 0.95 5039 91081535 XP_974904.1 2249 5.4e-250 PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921048|ref|XP_008192670.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921050|ref|XP_008192671.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|270006169|gb|EFA02617.1| hypothetical protein TcasGA2_TC008337 [Tribolium castaneum] 642921051 XM_969811.2 41 3.7028e-09 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase Suv4-20 (LOC663776), transcript variant X3, mRNA K11429 SUV420H histone-lysine N-methyltransferase SUV420H http://www.genome.jp/dbget-bin/www_bget?ko:K11429 Q9W5E0 1092 3.2e-117 Histone-lysine N-methyltransferase Suv4-20 OS=Drosophila melanogaster GN=Hmt4-20 PE=1 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2589 Histone tail methylase Cluster-8309.25055 BP_3 1059.95 10.41 5199 642934658 XP_008197755.1 4283 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.05495e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 531 3.7e-52 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF01702//PF08727 PDZ domain (Also known as DHR or GLGF)//Queuine tRNA-ribosyltransferase//Poliovirus 3A protein like GO:0006400//GO:0006508//GO:0006144//GO:0008616 tRNA modification//proteolysis//purine nucleobase metabolic process//queuosine biosynthetic process GO:0017111//GO:0004197//GO:0003968//GO:0005515//GO:0008479 nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity//protein binding//queuine tRNA-ribosyltransferase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.25057 BP_3 31.60 1.57 1263 189233697 XP_966459.2 603 9.8e-60 PREDICTED: uncharacterized protein C17orf59 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66H43 128 4.9e-06 Uncharacterized protein C17orf59 homolog OS=Rattus norvegicus PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25058 BP_3 13.33 0.55 1466 642919467 XP_008191881.1 808 1.9e-83 PREDICTED: polyprenol reductase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12345 SRD5A3 3-oxo-5-alpha-steroid 4-dehydrogenase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12345 Q9VLP9 526 4.0e-52 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0005737//GO:0016021 cytoplasm//integral component of membrane KOG1640 Predicted steroid reductase Cluster-8309.25063 BP_3 173.09 1.88 4736 270013440 EFA09888.1 842 7.1e-87 hypothetical protein TcasGA2_TC012037 [Tribolium castaneum] -- -- -- -- -- K08497 SEC20 protein transport protein SEC20 http://www.genome.jp/dbget-bin/www_bget?ko:K08497 Q12981 377 2.4e-34 Vesicle transport protein SEC20 OS=Homo sapiens GN=BNIP1 PE=1 SV=3 PF03836//PF13890//PF04513 RasGAP C-terminus//Rab3 GTPase-activating protein catalytic subunit//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007264 small GTPase mediated signal transduction GO:0005198//GO:0005096 structural molecule activity//GTPase activator activity GO:0019031//GO:0019028 viral envelope//viral capsid -- -- Cluster-8309.25066 BP_3 723.95 29.77 1464 91080041 XP_972705.1 1298 2.9e-140 PREDICTED: tumor susceptibility gene 101 protein [Tribolium castaneum]>gi|270003221|gb|EEZ99668.1| hypothetical protein TcasGA2_TC002425 [Tribolium castaneum] -- -- -- -- -- K12183 TSG101, STP22, VPS23 ESCRT-I complex subunit TSG101 http://www.genome.jp/dbget-bin/www_bget?ko:K12183 Q61187 450 2.6e-43 Tumor susceptibility gene 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2 PF02601//PF09177//PF03938//PF01496//PF05743//PF01763//PF04977//PF04111 Exonuclease VII, large subunit//Syntaxin 6, N-terminal//Outer membrane protein (OmpH-like)//V-type ATPase 116kDa subunit family//UEV domain//Herpesvirus UL6 like//Septum formation initiator//Autophagy protein Apg6 GO:0006464//GO:0015991//GO:0048193//GO:0006914//GO:0015031//GO:0006323//GO:0007049//GO:0015992//GO:0006308 cellular protein modification process//ATP hydrolysis coupled proton transport//Golgi vesicle transport//autophagy//protein transport//DNA packaging//cell cycle//proton transport//DNA catabolic process GO:0008855//GO:0015078//GO:0051082 exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//unfolded protein binding GO:0016020//GO:0009318//GO:0033179 membrane//exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain KOG2391 Vacuolar sorting protein/ubiquitin receptor VPS23 Cluster-8309.25067 BP_3 10.00 0.79 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25071 BP_3 122.25 1.77 3625 642921203 XP_008192760.1 1312 1.7e-141 PREDICTED: uncharacterized protein LOC103312841 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 P82798 286 6.6e-24 Transcriptional regulator ATRX (Fragment) OS=Macropus eugenii GN=ATRX PE=2 SV=1 PF00539//PF00628//PF01152 Transactivating regulatory protein (Tat)//PHD-finger//Bacterial-like globin GO:0006355 regulation of transcription, DNA-templated GO:0019825//GO:0005515//GO:0003700 oxygen binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.25072 BP_3 263.00 8.46 1790 91091998 XP_969961.1 992 1.1e-104 PREDICTED: syntaxin-18 [Tribolium castaneum]>gi|642937771|ref|XP_008198938.1| PREDICTED: syntaxin-18 [Tribolium castaneum]>gi|270001158|gb|EEZ97605.1| hypothetical protein TcasGA2_TC011475 [Tribolium castaneum] -- -- -- -- -- K08492 STX18 syntaxin 18 http://www.genome.jp/dbget-bin/www_bget?ko:K08492 Q8VDS8 557 1.2e-55 Syntaxin-18 OS=Mus musculus GN=Stx18 PE=2 SV=2 PF05739//PF07851//PF07998//PF00170 SNARE domain//TMPIT-like protein//Peptidase family M54//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0005515//GO:0003700 zinc ion binding//sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG3894 SNARE protein Syntaxin 18/UFE1 Cluster-8309.25074 BP_3 169.00 9.93 1112 189241033 XP_971712.2 357 2.9e-31 PREDICTED: probable peptide chain release factor C12orf65, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5WUX7 273 6.6e-23 Probable peptide chain release factor C12orf65 homolog, mitochondrial OS=Danio rerio GN=si:ch211-275j6.5 PE=3 SV=1 PF00472 RF-1 domain GO:0006449//GO:0006415 regulation of translational termination//translational termination GO:0003747 translation release factor activity GO:0005840//GO:0018444 ribosome//translation release factor complex KOG2726 Mitochondrial polypeptide chain release factor Cluster-8309.25077 BP_3 35.85 1.55 1404 270008898 EFA05346.1 296 4.3e-24 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 170 7.3e-11 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF02148 Zn-finger in ubiquitin-hydrolases and other protein -- -- GO:0008270 zinc ion binding -- -- KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.25078 BP_3 8.05 0.51 1058 642925667 XP_008194662.1 631 4.7e-63 PREDICTED: uncharacterized protein LOC663019 isoform X2 [Tribolium castaneum]>gi|270008899|gb|EFA05347.1| hypothetical protein TcasGA2_TC015511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25080 BP_3 17.05 0.62 1624 546684909 ERL94491.1 1492 1.0e-162 hypothetical protein D910_11768 [Dendroctonus ponderosae] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50430 822 2.1e-86 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.25081 BP_3 898.12 11.11 4187 642934418 XP_008197653.1 541 5.0e-52 PREDICTED: transformer-2 protein homolog beta isoform X4 [Tribolium castaneum] 642934413 XM_008199429.1 299 1.16424e-152 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X2, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 3.7e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF00076//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.25085 BP_3 39.92 0.64 3317 642931826 XP_971415.2 670 4.4e-67 PREDICTED: runt-related transcription factor 3 [Tribolium castaneum] 768414739 XM_011549587.1 112 8.25323e-49 PREDICTED: Plutella xylostella runt-related transcription factor 3 (LOC105380090), mRNA K09278 RUNX2, AML3 runt-related transcription factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09278 Q9W349 485 5.1e-47 Protein lozenge OS=Drosophila melanogaster GN=lz PE=2 SV=2 PF00853//PF15800 Runt domain//Clock interacting protein circadian GO:0045892//GO:0006355//GO:0042754 negative regulation of transcription, DNA-templated//regulation of transcription, DNA-templated//negative regulation of circadian rhythm GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3982 Runt and related transcription factors Cluster-8309.25086 BP_3 385.08 5.82 3479 642931826 XP_971415.2 1148 1.7e-122 PREDICTED: runt-related transcription factor 3 [Tribolium castaneum] 768414739 XM_011549587.1 112 8.66073e-49 PREDICTED: Plutella xylostella runt-related transcription factor 3 (LOC105380090), mRNA K08367 RUNX1, AML1 runt-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08367 Q9W349 529 4.2e-52 Protein lozenge OS=Drosophila melanogaster GN=lz PE=2 SV=2 PF15800//PF00853 Clock interacting protein circadian//Runt domain GO:0045892//GO:0006355//GO:0042754 negative regulation of transcription, DNA-templated//regulation of transcription, DNA-templated//negative regulation of circadian rhythm GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3982 Runt and related transcription factors Cluster-8309.2509 BP_3 3.00 0.39 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25090 BP_3 7.67 0.31 1499 91088343 XP_971105.1 359 2.3e-31 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q91X52 248 7.0e-20 L-xylulose reductase OS=Mus musculus GN=Dcxr PE=2 SV=2 PF02882//PF12242//PF02826//PF00743//PF01370//PF00106 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Flavin-binding monooxygenase-like//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0009396//GO:0046487//GO:0008152//GO:0055114 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//metabolic process//oxidation-reduction process GO:0016491//GO:0004488//GO:0051287//GO:0004499//GO:0050661//GO:0003824//GO:0050662//GO:0050660//GO:0000166 oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//NAD binding//N,N-dimethylaniline monooxygenase activity//NADP binding//catalytic activity//coenzyme binding//flavin adenine dinucleotide binding//nucleotide binding -- -- KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.25091 BP_3 275.21 4.00 3609 478250074 ENN70580.1 978 9.2e-103 hypothetical protein YQE_12755, partial [Dendroctonus ponderosae]>gi|546672658|gb|ERL84454.1| hypothetical protein D910_01886 [Dendroctonus ponderosae] 642933290 XM_008199137.1 98 5.44763e-41 PREDICTED: Tribolium castaneum cytochrome b5 reductase 4 (LOC656620), transcript variant X2, mRNA K00326 E1.6.2.2 cytochrome-b5 reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00326 Q68EJ0 395 1.5e-36 Cytochrome b5 reductase 4 OS=Rattus norvegicus GN=Cyb5r4 PE=1 SV=2 PF08030//PF00175 Ferric reductase NAD binding domain//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0536 Flavohemoprotein b5+b5R Cluster-8309.25092 BP_3 285.00 10.67 1579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04053 Coatomer WD associated region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198 structural molecule activity GO:0030117 membrane coat -- -- Cluster-8309.25093 BP_3 226.18 3.24 3655 642924025 XP_008193975.1 1924 1.9e-212 PREDICTED: WD repeat-containing protein 37 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DDF0 1066 2.4e-114 WD repeat-containing protein 37 OS=Xenopus laevis GN=wdr37 PE=2 SV=1 PF15898//PF02183//PF00400 cGMP-dependent protein kinase interacting domain//Homeobox associated leucine zipper//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0019901//GO:0043565//GO:0005515//GO:0003700 protein kinase binding//sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG0300 WD40 repeat-containing protein Cluster-8309.25094 BP_3 176.82 2.55 3639 642924025 XP_008193975.1 1823 9.7e-201 PREDICTED: WD repeat-containing protein 37 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R650 1015 2.0e-108 WD repeat-containing protein 37 OS=Pongo abelii GN=WDR37 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0300 WD40 repeat-containing protein Cluster-8309.25095 BP_3 86.00 9.82 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25096 BP_3 397.53 5.07 4069 642936958 XP_008198629.1 569 2.8e-55 PREDICTED: bromodomain-containing protein 4-like [Tribolium castaneum]>gi|270001028|gb|EEZ97475.1| hypothetical protein TcasGA2_TC011309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25097 BP_3 419.00 9.01 2532 91084817 XP_973265.1 2979 0.0e+00 PREDICTED: ribosome biogenesis protein BOP1 homolog [Tribolium castaneum]>gi|270008960|gb|EFA05408.1| hypothetical protein TcasGA2_TC015584 [Tribolium castaneum] 571500889 XM_006561925.1 119 8.07038e-53 PREDICTED: Apis mellifera ribosome biogenesis protein BOP1 homolog (LOC551531), mRNA K14824 ERB1, BOP1 ribosome biogenesis protein ERB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14824 Q17LZ2 2486 3.6e-279 Ribosome biogenesis protein BOP1 homolog OS=Aedes aegypti GN=AAEL001169 PE=3 SV=1 PF01643//PF15957//PF00400//PF00335//PF08145 Acyl-ACP thioesterase//Commissureless//WD domain, G-beta repeat//Tetraspanin family//BOP1NT (NUC169) domain GO:0006364//GO:0006633//GO:0007411//GO:0051726 rRNA processing//fatty acid biosynthetic process//axon guidance//regulation of cell cycle GO:0016790//GO:0005515 thiolester hydrolase activity//protein binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis Cluster-8309.25098 BP_3 510.39 5.76 4561 728418761 AIY68380.1 1519 2.2e-165 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 709 7.5e-73 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF12763//PF08115//PF13499//PF01153//PF13833//PF13405//PF00326//PF07859//PF13202//PF00036//PF03874 Cytoskeletal-regulatory complex EF hand//SFI toxin family//EF-hand domain pair//Glypican//EF-hand domain pair//EF-hand domain//Prolyl oligopeptidase family//alpha/beta hydrolase fold//EF hand//EF hand//RNA polymerase Rpb4 GO:0006351//GO:0008152//GO:0006144//GO:0006508//GO:0006206//GO:0009405 transcription, DNA-templated//metabolic process//purine nucleobase metabolic process//proteolysis//pyrimidine nucleobase metabolic process//pathogenesis GO:0005515//GO:0005509//GO:0043395//GO:0016787//GO:0003899//GO:0008236 protein binding//calcium ion binding//heparan sulfate proteoglycan binding//hydrolase activity//DNA-directed RNA polymerase activity//serine-type peptidase activity GO:0016020//GO:0005576//GO:0005578//GO:0005730 membrane//extracellular region//proteinaceous extracellular matrix//nucleolus -- -- Cluster-8309.25099 BP_3 423.38 4.12 5239 728418761 AIY68380.1 1520 1.9e-165 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 711 5.0e-73 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF07859//PF13202//PF00326//PF03874//PF00036//PF08463//PF08115//PF12763//PF13405//PF13833//PF13499//PF01153 alpha/beta hydrolase fold//EF hand//Prolyl oligopeptidase family//RNA polymerase Rpb4//EF hand//EcoEI R protein C-terminal//SFI toxin family//Cytoskeletal-regulatory complex EF hand//EF-hand domain//EF-hand domain pair//EF-hand domain pair//Glypican GO:0006206//GO:0006508//GO:0006351//GO:0008152//GO:0006144//GO:0006304//GO:0009405 pyrimidine nucleobase metabolic process//proteolysis//transcription, DNA-templated//metabolic process//purine nucleobase metabolic process//DNA modification//pathogenesis GO:0005509//GO:0003677//GO:0003824//GO:0005515//GO:0008236//GO:0043395//GO:0016787//GO:0003899 calcium ion binding//DNA binding//catalytic activity//protein binding//serine-type peptidase activity//heparan sulfate proteoglycan binding//hydrolase activity//DNA-directed RNA polymerase activity GO:0016020//GO:0005576//GO:0005578//GO:0005730 membrane//extracellular region//proteinaceous extracellular matrix//nucleolus -- -- Cluster-8309.251 BP_3 27.00 0.99 1605 642933863 XP_008197542.1 1136 2.0e-121 PREDICTED: 5-hydroxytryptamine receptor-like [Tribolium castaneum] 768430080 XM_011557948.1 176 1.04532e-84 PREDICTED: Plutella xylostella 5-hydroxytryptamine receptor-like (LOC105387247), partial mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q17239 906 3.8e-96 5-hydroxytryptamine receptor OS=Bombyx mori PE=2 SV=1 PF00001//PF03821 7 transmembrane receptor (rhodopsin family)//Golgi 4-transmembrane spanning transporter GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.25100 BP_3 58.00 2.87 1267 -- -- -- -- -- 462346509 APGK01034266.1 92 4.06727e-38 Dendroctonus ponderosae Seq01034276, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25102 BP_3 9.00 2.99 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25103 BP_3 105.60 2.05 2776 642923711 XP_974199.2 2950 0.0e+00 PREDICTED: protein smg8 [Tribolium castaneum] -- -- -- -- -- K18734 SMG8 protein SMG8 http://www.genome.jp/dbget-bin/www_bget?ko:K18734 B0W730 645 1.2e-65 Protein SMG8 OS=Culex quinquefasciatus GN=CPIJ003128 PE=3 SV=1 PF10220//PF08653 Uncharacterized conserved protein (DUF2146)//DASH complex subunit Dam1 GO:0000184//GO:0008608 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG3692 Uncharacterized conserved protein Cluster-8309.25106 BP_3 1.00 17.59 229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25107 BP_3 669.58 5.53 6124 91076220 XP_972698.1 2878 0.0e+00 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum]>gi|270014737|gb|EFA11185.1| hypothetical protein TcasGA2_TC004793 [Tribolium castaneum] 462373375 APGK01024771.1 212 3.93912e-104 Dendroctonus ponderosae Seq01024781, whole genome shotgun sequence K14353 SLCO3A solute carrier organic anion transporter family, member 3A http://www.genome.jp/dbget-bin/www_bget?ko:K14353 Q9H2Y9 912 2.9e-96 Solute carrier organic anion transporter family member 5A1 OS=Homo sapiens GN=SLCO5A1 PE=2 SV=2 PF03137//PF07690//PF00050//PF07648 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0006810//GO:0055085 transport//transmembrane transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.25108 BP_3 6.00 0.35 1107 478263437 ENN81798.1 187 1.5e-11 hypothetical protein YQE_01804, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02943 Ferredoxin thioredoxin reductase catalytic beta chain GO:0055114 oxidation-reduction process GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors -- -- -- -- Cluster-8309.2511 BP_3 183.58 4.84 2119 642922070 XP_008193006.1 379 1.6e-33 PREDICTED: cuticle protein 19-like [Tribolium castaneum]>gi|270008195|gb|EFA04643.1| cuticular protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 283 8.7e-24 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.25112 BP_3 40.00 1.30 1777 332372967 AEE61625.1 1127 2.4e-120 unknown [Dendroctonus ponderosae]>gi|546687201|gb|ERL96033.1| hypothetical protein D910_00850 [Dendroctonus ponderosae] 332372966 BT126662.1 195 3.17948e-95 Dendroctonus ponderosae clone DPO112_K06 unknown mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 512 2.0e-50 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.25113 BP_3 212.68 7.74 1617 91076712 XP_972315.1 865 5.2e-90 PREDICTED: protein MAK16 homolog [Tribolium castaneum]>gi|270001893|gb|EEZ98340.1| hypothetical protein TcasGA2_TC000795 [Tribolium castaneum] 676494334 XM_009068281.1 96 3.12113e-40 Lottia gigantea hypothetical protein mRNA K14831 MAK16 protein MAK16 http://www.genome.jp/dbget-bin/www_bget?ko:K14831 Q66L33 628 6.5e-64 Protein MAK16 homolog A OS=Xenopus laevis GN=mak16-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3064 RNA-binding nuclear protein (MAK16) containing a distinct C4 Zn-finger Cluster-8309.25114 BP_3 3.00 0.63 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25115 BP_3 759.00 72.55 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.25117 BP_3 637.23 14.35 2432 642922652 XP_008193262.1 1670 3.6e-183 PREDICTED: mediator of RNA polymerase II transcription subunit 15-like [Tribolium castaneum]>gi|270007150|gb|EFA03598.1| hypothetical protein TcasGA2_TC013685 [Tribolium castaneum] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 757 1.1e-78 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF02172//PF09606 KIX domain//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003712//GO:0001104 transcription cofactor activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005667 mediator complex//transcription factor complex -- -- Cluster-8309.25118 BP_3 73.48 0.86 4426 642922652 XP_008193262.1 1318 4.2e-142 PREDICTED: mediator of RNA polymerase II transcription subunit 15-like [Tribolium castaneum]>gi|270007150|gb|EFA03598.1| hypothetical protein TcasGA2_TC013685 [Tribolium castaneum] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 758 1.5e-78 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF09606//PF02172//PF16987 ARC105 or Med15 subunit of Mediator complex non-fungal//KIX domain//KIX domain GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003712//GO:0001104 transcription cofactor activity//RNA polymerase II transcription cofactor activity GO:0005667//GO:0016592 transcription factor complex//mediator complex -- -- Cluster-8309.25119 BP_3 410.33 3.71 5617 189241815 XP_971376.2 4256 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1079 1.1e-115 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF13180//PF00397//PF00595 PDZ domain//WW domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.25122 BP_3 786.35 18.93 2294 270014969 EFA11417.1 762 6.5e-78 hypothetical protein TcasGA2_TC013593 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25124 BP_3 80.13 0.80 5100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00424//PF05699//PF11837//PF02505 REV protein (anti-repression trans-activator protein)//hAT family C-terminal dimerisation region//Domain of unknown function (DUF3357)//Methyl-coenzyme M reductase operon protein D GO:0006355//GO:0006012//GO:0005985//GO:0015948//GO:0005982 regulation of transcription, DNA-templated//galactose metabolic process//sucrose metabolic process//methanogenesis//starch metabolic process GO:0004564//GO:0003700//GO:0046983//GO:0004575 beta-fructofuranosidase activity//transcription factor activity, sequence-specific DNA binding//protein dimerization activity//sucrose alpha-glucosidase activity GO:0017177//GO:0005667//GO:0042025 glucosidase II complex//transcription factor complex//host cell nucleus -- -- Cluster-8309.25127 BP_3 8.00 0.65 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25129 BP_3 14.85 0.57 1547 642919263 XP_008191800.1 1099 3.7e-117 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- K13880 BEST3, VMD2L3 bestrophin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K13880 Q8N1M1 616 1.5e-62 Bestrophin-3 OS=Homo sapiens GN=BEST3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.25133 BP_3 5.48 2.72 387 606236564 AHW40461.1 605 1.8e-60 actin, partial [Zygaena filipendulae] 530723032 KC131028.1 252 1.33186e-127 Portunus trituberculatus skeletal muscle actin 2 mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P10987 596 8.0e-61 Actin-5C OS=Drosophila melanogaster GN=Act5C PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.25134 BP_3 2.00 1.61 346 768189842 KJH46221.1 451 1.1e-42 Actin [Dictyocaulus viviparus] 338224304 HM217789.1 236 9.23317e-119 Scylla paramamosain isolate 1 cytoplasmic type actin-like mRNA, partial sequence K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P12431 442 5.2e-43 Actin, muscle OS=Strongylocentrotus purpuratus PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.25135 BP_3 224.19 2.93 3979 189237657 XP_001812177.1 794 2.2e-81 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 352 1.6e-31 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01428//PF01536 AN1-like Zinc finger//Adenosylmethionine decarboxylase GO:0006525//GO:0006560//GO:0008295//GO:0006597 arginine metabolic process//proline metabolic process//spermidine biosynthetic process//spermine biosynthetic process GO:0008270//GO:0004014 zinc ion binding//adenosylmethionine decarboxylase activity -- -- KOG3183 Predicted Zn-finger protein Cluster-8309.25136 BP_3 112.89 4.12 1611 189237657 XP_001812177.1 383 4.1e-34 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 204 9.5e-15 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01428 AN1-like Zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.25137 BP_3 55.26 0.51 5488 642916535 XP_008191598.1 626 9.2e-62 PREDICTED: probable serine/threonine-protein kinase nek3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W2E1 367 4.1e-33 Protein stum OS=Drosophila melanogaster GN=stum PE=2 SV=3 PF14525 AraC-binding-like domain GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.25138 BP_3 153.18 1.56 5025 642914078 XP_969963.3 2060 4.4e-228 PREDICTED: uncharacterized protein LOC658486 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05529//PF15898//PF17078//PF15177 B-cell receptor-associated protein 31-like//cGMP-dependent protein kinase interacting domain//SWI5-dependent HO expression protein 3//Interleukin-28A GO:0007165//GO:0007259//GO:0051028//GO:0051607//GO:0050778//GO:0006886//GO:0048309 signal transduction//JAK-STAT cascade//mRNA transport//defense response to virus//positive regulation of immune response//intracellular protein transport//endoplasmic reticulum inheritance GO:0019901//GO:0005125 protein kinase binding//cytokine activity GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.25140 BP_3 43.88 4.60 752 91086459 XP_969641.1 393 1.3e-35 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Tribolium castaneum] -- -- -- -- -- K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 O62515 236 8.6e-19 Probable phytanoyl-CoA dioxygenase OS=Caenorhabditis elegans GN=ZK550.6 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25144 BP_3 13.19 0.33 2227 229892267 NP_001153545.1 1441 1.2e-156 uncharacterized MFS-type transporter [Tribolium castaneum]>gi|270007334|gb|EFA03782.1| hypothetical protein TcasGA2_TC013893 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NT16 535 5.5e-53 MFS-type transporter SLC18B1 OS=Homo sapiens GN=SLC18B1 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.25145 BP_3 24.00 0.69 1977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25146 BP_3 891.46 19.13 2538 229892267 NP_001153545.1 2079 1.4e-230 uncharacterized MFS-type transporter [Tribolium castaneum]>gi|270007334|gb|EFA03782.1| hypothetical protein TcasGA2_TC013893 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NT16 648 4.9e-66 MFS-type transporter SLC18B1 OS=Homo sapiens GN=SLC18B1 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.25147 BP_3 55.74 1.16 2608 189235703 XP_001807591.1 2643 5.7e-296 PREDICTED: CAS1 domain-containing protein 1 [Tribolium castaneum] 642917634 XM_001807539.2 82 3.07682e-32 PREDICTED: Tribolium castaneum CAS1 domain-containing protein 1 (LOC655926), mRNA -- -- -- -- Q7TN73 1227 3.7e-133 CAS1 domain-containing protein 1 OS=Mus musculus GN=Casd1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1699 O-acetyltransferase Cluster-8309.25155 BP_3 90.89 1.59 3043 546673157 ERL84822.1 2139 1.8e-237 hypothetical protein D910_02246 [Dendroctonus ponderosae] 501300159 AK418404.1 119 9.71567e-53 Riptortus pedestris mRNA for cytoplasmic dynein intermediate chain, partial cds, sequence id: Rped-0877, expressed in midgut K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 1711 3.2e-189 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.25156 BP_3 53.53 0.76 3686 91091602 XP_975764.1 2842 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X7 [Tribolium castaneum] 642937044 XM_970671.2 557 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X7, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 1982 1.5e-220 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF00400//PF09266//PF11540 WD domain, G-beta repeat//Viral DNA topoisomerase I, N-terminal//Cytoplasmic dynein 1 intermediate chain 2 GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0003916//GO:0005515//GO:0003677 DNA topoisomerase activity//protein binding//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.25157 BP_3 57.41 0.99 3093 642937041 XP_008198664.1 1343 3.7e-145 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X5 [Tribolium castaneum] 501300159 AK418404.1 77 2.19941e-29 Riptortus pedestris mRNA for cytoplasmic dynein intermediate chain, partial cds, sequence id: Rped-0877, expressed in midgut K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 O88487 947 1.3e-100 Cytoplasmic dynein 1 intermediate chain 2 OS=Mus musculus GN=Dync1i2 PE=1 SV=1 PF00400//PF02742 WD domain, G-beta repeat//Iron dependent repressor, metal binding and dimerisation domain -- -- GO:0046914//GO:0046983//GO:0005515 transition metal ion binding//protein dimerization activity//protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.2516 BP_3 3.00 0.48 592 768430524 XP_011556494.1 166 2.2e-09 PREDICTED: uncharacterized protein LOC105387464 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25160 BP_3 285.12 4.10 3646 642938137 XP_008199781.1 1838 1.8e-202 PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|642938140|ref|XP_008199782.1| PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|270016485|gb|EFA12931.1| hypothetical protein TcasGA2_TC010477 [Tribolium castaneum] 194750862 XM_001957713.1 248 2.2706e-124 Drosophila ananassae GF10569 (Dana\GF10569), mRNA K08827 PRPF4B serine/threonine-protein kinase PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K08827 Q13523 1338 6.9e-146 Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens GN=PRPF4B PE=1 SV=3 PF05445//PF07714//PF00069 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0670 U4/U6-associated splicing factor PRP4 Cluster-8309.25161 BP_3 387.15 5.96 3425 642938137 XP_008199781.1 1838 1.7e-202 PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|642938140|ref|XP_008199782.1| PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|270016485|gb|EFA12931.1| hypothetical protein TcasGA2_TC010477 [Tribolium castaneum] 194750862 XM_001957713.1 248 2.1316e-124 Drosophila ananassae GF10569 (Dana\GF10569), mRNA K08827 PRPF4B serine/threonine-protein kinase PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K08827 Q13523 1338 6.5e-146 Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens GN=PRPF4B PE=1 SV=3 PF00069//PF07714//PF05445 Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0670 U4/U6-associated splicing factor PRP4 Cluster-8309.25162 BP_3 13.08 0.36 2023 642924858 XP_008194069.1 1120 1.8e-119 PREDICTED: uncharacterized protein LOC103313199 [Tribolium castaneum]>gi|270006682|gb|EFA03130.1| hypothetical protein TcasGA2_TC013041 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04333//PF00168 MlaA lipoprotein//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.25163 BP_3 2.00 0.36 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25165 BP_3 147.09 6.17 1440 642920402 XP_008192333.1 149 4.9e-07 PREDICTED: uncharacterized protein LOC664268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25166 BP_3 192.32 1.54 6304 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.28922e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.2e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF00787//PF00018//PF14604//PF00620//PF01929 PX domain//SH3 domain//Variant SH3 domain//RhoGAP domain//Ribosomal protein L14 GO:0007154//GO:0042254//GO:0006412//GO:0007165 cell communication//ribosome biogenesis//translation//signal transduction GO:0003735//GO:0035091//GO:0005515 structural constituent of ribosome//phosphatidylinositol binding//protein binding GO:0005840//GO:0005622 ribosome//intracellular KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.25167 BP_3 174.44 1.02 8552 478251250 ENN71724.1 426 2.2e-38 hypothetical protein YQE_11647, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00285 Citrate synthase -- -- GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer -- -- -- -- Cluster-8309.25169 BP_3 3.00 1.01 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25172 BP_3 1060.71 16.18 3452 642924116 XP_008194013.1 1767 2.9e-194 PREDICTED: growth factor receptor-bound protein 14-like isoform X3 [Tribolium castaneum] 642924115 XM_008195791.1 53 5.39579e-16 PREDICTED: Tribolium castaneum growth factor receptor-bound protein 14-like (LOC657107), transcript variant X3, mRNA -- -- -- -- Q5ICW4 730 2.1e-75 Growth factor receptor-bound protein 14 OS=Bos taurus GN=GRB14 PE=1 SV=1 PF05356//PF00788 Phage Coat protein B//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- GO:0019028 viral capsid KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.25173 BP_3 1001.00 8.80 5773 91076464 XP_971999.1 5711 0.0e+00 PREDICTED: slit homolog 2 protein [Tribolium castaneum]>gi|270002905|gb|EEZ99352.1| toll-6 [Tribolium castaneum] 817193060 XM_012416560.1 120 5.15379e-53 PREDICTED: Orussus abietinus protein toll-like (LOC105695206), mRNA -- -- -- -- O75094 422 1.8e-39 Slit homolog 3 protein OS=Homo sapiens GN=SLIT3 PE=2 SV=3 PF01582//PF00560//PF13676//PF13855 TIR domain//Leucine Rich Repeat//TIR domain//Leucine rich repeat GO:0007165//GO:0045087 signal transduction//innate immune response GO:0004888//GO:0005515 transmembrane signaling receptor activity//protein binding GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.25175 BP_3 423.33 6.03 3674 642917307 XP_008199245.1 5410 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X6 [Tribolium castaneum] 665815961 XM_008558446.1 642 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3654 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF00501//PF06464//PF17096 AMP-binding enzyme//DMAP1-binding Domain//Altered inheritance of mitochondria protein 3 GO:0008152//GO:0051016 metabolic process//barbed-end actin filament capping GO:0003824//GO:0008134 catalytic activity//transcription factor binding GO:0005634//GO:0030479//GO:0005667 nucleus//actin cortical patch//transcription factor complex KOG3628 Predicted AMP-binding protein Cluster-8309.25179 BP_3 767.01 3.14 12078 642931485 XP_008196605.1 917 3.7e-95 PREDICTED: insulin receptor substrate 1 isoform X9 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 P84770 503 1.5e-48 Insulin receptor substrate 1-B OS=Xenopus laevis GN=irs1-b PE=2 SV=1 PF02174//PF12814 PTB domain (IRS-1 type)//Meiotic cell cortex C-terminal pleckstrin homology GO:0032065//GO:0007165 cortical protein anchoring//signal transduction GO:0005158//GO:0005543//GO:0005515 insulin receptor binding//phospholipid binding//protein binding GO:0005938//GO:0005899 cell cortex//insulin receptor complex -- -- Cluster-8309.25180 BP_3 31.97 1.04 1779 642911571 XP_008199480.1 1974 1.5e-218 PREDICTED: solute carrier family 41 member 1-like [Tribolium castaneum] 642911570 XM_008201258.1 420 0 PREDICTED: Tribolium castaneum solute carrier family 41 member 1-like (LOC662863), mRNA K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1136 8.9e-123 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF04093 Divalent cation transporter//rod shape-determining protein MreD GO:0008360//GO:0006812 regulation of cell shape//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG3788 Predicted divalent cation transporter Cluster-8309.25182 BP_3 2.00 1.02 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25183 BP_3 418.86 4.34 4945 478254843 ENN75079.1 2366 1.4e-263 hypothetical protein YQE_08392, partial [Dendroctonus ponderosae]>gi|546676933|gb|ERL87857.1| hypothetical protein D910_05245 [Dendroctonus ponderosae] 611988503 XM_007481079.1 72 2.12563e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 1364 9.0e-149 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF13180//PF00595//PF08001//PF00610//PF02273 PDZ domain//PDZ domain (Also known as DHR or GLGF)//CMV US//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Acyl transferase GO:0006631//GO:0030683//GO:0035556 fatty acid metabolic process//evasion or tolerance by virus of host immune response//intracellular signal transduction GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0044386 integral to host endoplasmic reticulum membrane KOG3571 Dishevelled 3 and related proteins Cluster-8309.25184 BP_3 68.23 0.70 4966 642926739 XP_008194992.1 2365 1.9e-263 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X2 [Tribolium castaneum] 611988503 XM_007481079.1 71 7.67784e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 1368 3.1e-149 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF02273//PF00610//PF08001//PF00595//PF13180 Acyl transferase//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//CMV US//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006631//GO:0030683//GO:0035556 fatty acid metabolic process//evasion or tolerance by virus of host immune response//intracellular signal transduction GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0044386 integral to host endoplasmic reticulum membrane KOG3571 Dishevelled 3 and related proteins Cluster-8309.25186 BP_3 227.36 3.64 3299 91084581 XP_973970.1 1723 3.5e-189 PREDICTED: signal peptide peptidase-like 3 isoform X1 [Tribolium castaneum]>gi|270008893|gb|EFA05341.1| hypothetical protein TcasGA2_TC015505 [Tribolium castaneum] 27820031 BT003288.1 200 9.89246e-98 Drosophila melanogaster GM06145 full insert cDNA K09598 SPPL3 signal peptide peptidase-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09598 Q9CUS9 1217 6.7e-132 Signal peptide peptidase-like 3 OS=Mus musculus GN=Sppl3 PE=1 SV=3 PF04258 Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.25188 BP_3 11.16 0.95 856 282158097 NP_001164092.1 284 6.5e-23 quaking related [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02289 Cyclohydrolase (MCH) GO:0006730//GO:0006807//GO:0046656 one-carbon metabolic process//nitrogen compound metabolic process//folic acid biosynthetic process GO:0018759 methenyltetrahydromethanopterin cyclohydrolase activity -- -- -- -- Cluster-8309.2519 BP_3 1.00 1.20 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25191 BP_3 207.43 3.41 3223 546681602 ERL91666.1 610 3.9e-60 hypothetical protein D910_08994 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZLX5 417 3.8e-39 Zinc finger Ran-binding domain-containing protein 2 OS=Gallus gallus GN=ZRANB2 PE=2 SV=1 PF02535//PF00641//PF00628//PF01080 ZIP Zinc transporter//Zn-finger in Ran binding protein and others//PHD-finger//Presenilin GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0008270//GO:0046873//GO:0004190//GO:0005515 zinc ion binding//metal ion transmembrane transporter activity//aspartic-type endopeptidase activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG1995 Conserved Zn-finger protein Cluster-8309.25192 BP_3 569.57 10.23 2976 546681602 ERL91666.1 610 3.6e-60 hypothetical protein D910_08994 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZLX5 417 3.5e-39 Zinc finger Ran-binding domain-containing protein 2 OS=Gallus gallus GN=ZRANB2 PE=2 SV=1 PF01080//PF00628//PF00641//PF02535 Presenilin//PHD-finger//Zn-finger in Ran binding protein and others//ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0004190//GO:0005515//GO:0046873//GO:0008270 aspartic-type endopeptidase activity//protein binding//metal ion transmembrane transporter activity//zinc ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1995 Conserved Zn-finger protein Cluster-8309.25193 BP_3 172.00 8.49 1268 91076844 XP_974775.1 912 1.5e-95 PREDICTED: probable enoyl-CoA hydratase, mitochondrial [Tribolium castaneum]>gi|270001819|gb|EEZ98266.1| hypothetical protein TcasGA2_TC000708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1ZXF1 301 4.2e-26 Probable enoyl-CoA hydratase, mitochondrial OS=Dictyostelium discoideum GN=echs1 PE=3 SV=1 PF00378//PF16113//PF11429//PF01343 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//Colicin D//Peptidase family S49 GO:0008152//GO:0006508//GO:0051252 metabolic process//proteolysis//regulation of RNA metabolic process GO:0003824//GO:0016836//GO:0008233//GO:0004540 catalytic activity//hydro-lyase activity//peptidase activity//ribonuclease activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.25194 BP_3 20.33 1.06 1216 91091510 XP_969238.1 329 5.6e-28 PREDICTED: 60S ribosomal protein L15 [Tribolium castaneum]>gi|642936867|ref|XP_008193026.1| PREDICTED: 60S ribosomal protein L15 [Tribolium castaneum]>gi|270000932|gb|EEZ97379.1| hypothetical protein TcasGA2_TC011204 [Tribolium castaneum] -- -- -- -- -- K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 P30736 268 2.7e-22 60S ribosomal protein L15 OS=Chironomus tentans GN=RpL15 PE=3 SV=3 PF00827 Ribosomal L15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-8309.25196 BP_3 587.69 8.21 3742 270001216 EEZ97663.1 4142 0.0e+00 hypothetical protein TcasGA2_TC016208 [Tribolium castaneum] 820865686 XM_012493878.1 479 0 PREDICTED: Apis florea ribonuclease 3 (LOC100863432), mRNA K03685 rnc, DROSHA, RNT1 ribonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K03685 Q9NRR4 2614 7.8e-294 Ribonuclease 3 OS=Homo sapiens GN=DROSHA PE=1 SV=2 PF00636//PF14622 Ribonuclease III domain//Ribonuclease-III-like GO:0051252//GO:0006396 regulation of RNA metabolic process//RNA processing GO:0003723//GO:0004525 RNA binding//ribonuclease III activity -- -- KOG1817 Ribonuclease Cluster-8309.25197 BP_3 198.38 3.44 3070 189233949 XP_001815164.1 2337 2.0e-260 PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911540|ref|XP_008199465.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911543|ref|XP_008199466.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum] 808116654 XM_012320378.1 112 7.63191e-49 PREDICTED: Bombus terrestris striatin-interacting protein 1 (LOC100642989), transcript variant X2, mRNA -- -- -- -- Q0P5J8 1890 5.7e-210 Striatin-interacting protein 1 OS=Bos taurus GN=STRIP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3680 Uncharacterized conserved protein Cluster-8309.25198 BP_3 21.00 1.01 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25199 BP_3 986.95 15.02 3458 91090880 XP_973129.1 851 4.7e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.4e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.25200 BP_3 293.39 4.37 3527 91090880 XP_973129.1 851 4.8e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.4e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.25201 BP_3 22.15 0.35 3376 91090880 XP_973129.1 851 4.6e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.3e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.25202 BP_3 57.90 0.86 3530 91090880 XP_973129.1 851 4.8e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.4e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.25203 BP_3 78.03 1.84 2333 91091704 XP_972821.1 1621 1.6e-177 PREDICTED: phosphatidylinositol 4-kinase beta [Tribolium castaneum]>gi|270001265|gb|EEZ97712.1| four wheel drive [Tribolium castaneum] 156717327 NM_001102734.1 64 2.78713e-22 Xenopus (Silurana) tropicalis phosphatidylinositol 4-kinase, catalytic, beta (pi4kb), mRNA >gnl|BL_ORD_ID|3952838 Xenopus tropicalis phosphatidylinositol 4-kinase, catalytic, beta, mRNA (cDNA clone MGC:122410 IMAGE:7649711), complete cds K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 B4UT09 690 6.1e-71 Phosphatidylinositol 4-kinase beta OS=Otolemur garnettii GN=PI4KB PE=3 SV=1 PF08288//PF07415 PIGA (GPI anchor biosynthesis)//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042//GO:0006506//GO:0006796 viral latency//GPI anchor biosynthetic process//phosphate-containing compound metabolic process GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0033644 host cell membrane KOG0903 Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion Cluster-8309.25205 BP_3 230.82 9.77 1431 642914885 XP_008190430.1 598 4.2e-59 PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914887|ref|XP_008190431.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914889|ref|XP_008190432.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 333 9.3e-30 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25207 BP_3 101.36 3.54 1673 189234930 XP_971266.2 529 5.0e-51 PREDICTED: CTL-like protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 331 1.9e-29 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25208 BP_3 66.00 6.72 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25209 BP_3 410.71 6.90 3160 642914891 XP_008190433.1 1677 7.1e-184 PREDICTED: CTL-like protein 2 isoform X2 [Tribolium castaneum] 620966641 XM_007658441.1 44 4.96959e-11 PREDICTED: Ornithorhynchus anatinus choline transporter-like protein 2 (LOC100086451), mRNA K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 1269 6.0e-138 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25211 BP_3 17.03 1.32 913 642914885 XP_008190430.1 598 2.7e-59 PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914887|ref|XP_008190431.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914889|ref|XP_008190432.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 333 5.9e-30 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25212 BP_3 174.50 3.37 2789 642914891 XP_008190433.1 1675 1.1e-183 PREDICTED: CTL-like protein 2 isoform X2 [Tribolium castaneum] 620966641 XM_007658441.1 44 4.37941e-11 PREDICTED: Ornithorhynchus anatinus choline transporter-like protein 2 (LOC100086451), mRNA K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 1269 5.3e-138 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25213 BP_3 58.04 1.32 2410 270002312 EEZ98759.1 468 8.5e-44 hypothetical protein TcasGA2_TC001323 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 331 2.7e-29 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 PF07962 Replication Fork Protection Component Swi3 GO:0007049//GO:0006974//GO:0048478 cell cycle//cellular response to DNA damage stimulus//replication fork protection -- -- GO:0005634 nucleus KOG1362 Choline transporter-like protein Cluster-8309.25216 BP_3 28.17 0.66 2337 -- -- -- -- -- 642920079 XM_001815999.2 51 4.70514e-15 PREDICTED: Tribolium castaneum uncharacterized LOC100142030 (LOC100142030), mRNA -- -- -- -- -- -- -- -- PF02751 Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.25217 BP_3 1579.27 18.56 4392 642936679 XP_008198534.1 629 3.3e-62 PREDICTED: protein rhomboid isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20350 202 4.4e-14 Protein rhomboid OS=Drosophila melanogaster GN=rho PE=1 SV=2 PF01694 Rhomboid family -- -- GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.2522 BP_3 162.00 10.14 1062 751441644 XP_011195425.1 150 2.8e-07 PREDICTED: extensin [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25220 BP_3 42.59 0.62 3579 642928866 XP_008195596.1 1882 1.4e-207 PREDICTED: protein EFR3 homolog cmp44E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IGJ0 959 6.0e-102 Protein EFR3 homolog cmp44E OS=Drosophila melanogaster GN=stmA PE=2 SV=3 PF07244 Surface antigen variable number repeat -- -- -- -- GO:0019867 outer membrane KOG1877 Putative transmembrane protein cmp44E Cluster-8309.25223 BP_3 346.00 4.91 3691 189233689 XP_001809624.1 995 1.0e-104 PREDICTED: uncharacterized protein LOC100142093 [Tribolium castaneum]>gi|270015089|gb|EFA11537.1| hypothetical protein TcasGA2_TC016058 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01670 Glycosyl hydrolase family 12 GO:0005982//GO:0000272//GO:0005985 starch metabolic process//polysaccharide catabolic process//sucrose metabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-8309.25228 BP_3 27.81 6.65 493 478258085 ENN78223.1 250 3.3e-19 hypothetical protein YQE_05375, partial [Dendroctonus ponderosae]>gi|546682769|gb|ERL92658.1| hypothetical protein D910_09971 [Dendroctonus ponderosae] -- -- -- -- -- K10428 DCTN6 dynactin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10428 Q9WUB4 207 1.3e-15 Dynactin subunit 6 OS=Mus musculus GN=Dctn6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25229 BP_3 132.00 5.56 1437 270009554 EFA06002.1 908 4.8e-95 hypothetical protein TcasGA2_TC008828 [Tribolium castaneum] -- -- -- -- -- K08742 SIAH2 E3 ubiquitin-protein ligase SIAH2 http://www.genome.jp/dbget-bin/www_bget?ko:K08742 A8X679 283 5.9e-24 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis briggsae GN=siah-1 PE=3 SV=2 PF00097//PF03145//PF02891//PF14634//PF15965 Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//MIZ/SP-RING zinc finger//zinc-RING finger domain//TRAF-like zinc-finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.25232 BP_3 687.03 13.35 2772 640802703 XP_008057688.1 799 4.0e-82 PREDICTED: zinc finger protein 658B-like [Tarsius syrichta] -- -- -- -- -- -- -- -- -- Q14590 778 4.5e-81 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF07776//PF16622//PF13912//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25233 BP_3 89.67 1.94 2522 332375390 AEE62836.1 714 2.6e-72 unknown [Dendroctonus ponderosae]>gi|478257091|gb|ENN77254.1| hypothetical protein YQE_06083, partial [Dendroctonus ponderosae] -- -- -- -- -- K07860 RAC2 Ras-related C3 botulinum toxin substrate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07860 Q24192 512 2.9e-50 Ras-like GTP-binding protein RhoL OS=Drosophila melanogaster GN=RhoL PE=2 SV=1 PF01926//PF00435//PF08477//PF00025//PF02465//PF08653//PF03205//PF00071 50S ribosome-binding GTPase//Spectrin repeat//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Flagellar hook-associated protein 2 N-terminus//DASH complex subunit Dam1//Molybdopterin guanine dinucleotide synthesis protein B//Ras family GO:0008608//GO:0006777//GO:0007264 attachment of spindle microtubules to kinetochore//Mo-molybdopterin cofactor biosynthetic process//small GTPase mediated signal transduction GO:0005515//GO:0005525 protein binding//GTP binding GO:0072686//GO:0042729//GO:0009424 mitotic spindle//DASH complex//bacterial-type flagellum hook KOG0393 Ras-related small GTPase, Rho type Cluster-8309.25234 BP_3 834.83 18.46 2472 332375390 AEE62836.1 714 2.6e-72 unknown [Dendroctonus ponderosae]>gi|478257091|gb|ENN77254.1| hypothetical protein YQE_06083, partial [Dendroctonus ponderosae] -- -- -- -- -- K07860 RAC2 Ras-related C3 botulinum toxin substrate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07860 Q24192 512 2.8e-50 Ras-like GTP-binding protein RhoL OS=Drosophila melanogaster GN=RhoL PE=2 SV=1 PF07361//PF00071//PF04210//PF04513//PF08653//PF03205//PF00025//PF08477//PF01926 Cytochrome b562//Ras family//Tetrahydromethanopterin S-methyltransferase, subunit G//Baculovirus polyhedron envelope protein, PEP, C terminus//DASH complex subunit Dam1//Molybdopterin guanine dinucleotide synthesis protein B//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0046656//GO:0008608//GO:0022900//GO:0006118//GO:0006777//GO:0015948//GO:0007264 folic acid biosynthetic process//attachment of spindle microtubules to kinetochore//electron transport chain//obsolete electron transport//Mo-molybdopterin cofactor biosynthetic process//methanogenesis//small GTPase mediated signal transduction GO:0030269//GO:0005198//GO:0005506//GO:0009055//GO:0005525//GO:0020037 tetrahydromethanopterin S-methyltransferase activity//structural molecule activity//iron ion binding//electron carrier activity//GTP binding//heme binding GO:0019028//GO:0016021//GO:0042729//GO:0042597//GO:0072686//GO:0019031 viral capsid//integral component of membrane//DASH complex//periplasmic space//mitotic spindle//viral envelope KOG0393 Ras-related small GTPase, Rho type Cluster-8309.25237 BP_3 31.19 0.60 2780 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25239 BP_3 695.71 8.86 4078 642920177 XP_008192234.1 3447 0.0e+00 PREDICTED: echinoderm microtubule-associated protein-like 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K18595 EML1_2 echinoderm microtubule-associated protein-like 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18595 Q4V8C3 1933 7.8e-215 Echinoderm microtubule-associated protein-like 1 OS=Rattus norvegicus GN=Eml1 PE=2 SV=2 PF00930//PF00400 Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains Cluster-8309.2524 BP_3 50.99 1.25 2264 808122580 XP_012164572.1 251 1.2e-18 PREDICTED: ecdysone-induced protein 78C isoform X2 [Bombus terrestris] -- -- -- -- -- K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25245 BP_3 25.51 1.25 1275 91080995 XP_975051.1 207 8.2e-14 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 611973182 XM_007473479.1 35 1.98719e-06 PREDICTED: Monodelphis domestica tudor domain containing 9 (TDRD9), mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 -- -- -- -- -- -- GO:0006457 protein folding GO:0005509//GO:0051082 calcium ion binding//unfolded protein binding GO:0005783 endoplasmic reticulum -- -- Cluster-8309.25247 BP_3 189.54 7.37 1531 642911933 XP_008199027.1 769 6.7e-79 PREDICTED: transmembrane protein 199 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N511 221 9.7e-17 Transmembrane protein 199 OS=Homo sapiens GN=TMEM199 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25249 BP_3 169.79 2.60 3435 642930234 XP_008196310.1 630 2.0e-62 PREDICTED: unc-112-related protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17083 FERMT2, KIND2 kindlin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17083 Q9VZI3 369 1.5e-33 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.25251 BP_3 23.26 4.78 526 675878356 XP_009024738.1 727 1.7e-74 hypothetical protein HELRODRAFT_155129 [Helobdella robusta]>gi|675883990|ref|XP_009027497.1| hypothetical protein HELRODRAFT_185105 [Helobdella robusta]>gi|675883992|ref|XP_009027498.1| hypothetical protein HELRODRAFT_185110 [Helobdella robusta]>gi|555691200|gb|ESN94432.1| hypothetical protein HELRODRAFT_185105 [Helobdella robusta]>gi|555691201|gb|ESN94433.1| hypothetical protein HELRODRAFT_185110 [Helobdella robusta]>gi|555694029|gb|ESN97261.1| hypothetical protein HELRODRAFT_155129 [Helobdella robusta] 823672677 KR711168.1 297 1.78617e-152 Synthetic construct Homo sapiens clone CCSBHm_00020922 ACTG1 (ACTG1) mRNA, encodes complete protein K12315 ACTG2 actin, gamma-enteric smooth muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12315 Q964E0 724 1.6e-75 Actin, cytoplasmic OS=Biomphalaria tenagophila PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.25252 BP_3 1.00 1.55 308 820857060 XP_012345672.1 450 1.3e-42 PREDICTED: actin, clone 205-like isoform X1 [Apis florea] 338224304 HM217789.1 252 1.03464e-127 Scylla paramamosain isolate 1 cytoplasmic type actin-like mRNA, partial sequence K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P0DM42 446 1.6e-43 Actin-3 OS=Caenorhabditis elegans GN=act-3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.25254 BP_3 128.65 1.18 5559 642938278 XP_008192712.1 3281 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 958 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.2e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF07714//PF00069//PF12142 Protein tyrosine kinase//Protein kinase domain//Polyphenol oxidase middle domain GO:0006118//GO:0055114//GO:0006468//GO:0006570 obsolete electron transport//oxidation-reduction process//protein phosphorylation//tyrosine metabolic process GO:0005524//GO:0004672//GO:0004097 ATP binding//protein kinase activity//catechol oxidase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.25255 BP_3 76.71 1.06 3774 91081335 XP_967042.1 5001 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X2 [Tribolium castaneum]>gi|270005182|gb|EFA01630.1| hypothetical protein TcasGA2_TC007200 [Tribolium castaneum] 820837636 XM_012494483.1 538 0 PREDICTED: Apis florea probable phosphorylase b kinase regulatory subunit alpha (LOC100865608), transcript variant X3, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 4145 0.0e+00 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 PF07525 SOCS box GO:0005977//GO:0005975//GO:0035556 glycogen metabolic process//carbohydrate metabolic process//intracellular signal transduction GO:0004553//GO:0005516 hydrolase activity, hydrolyzing O-glycosyl compounds//calmodulin binding -- -- KOG3635 Phosphorylase kinase Cluster-8309.25258 BP_3 520.77 7.53 3626 642935103 XP_008197888.1 1698 3.0e-186 PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935105|ref|XP_008197889.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935107|ref|XP_008197890.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935109|ref|XP_008197891.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935111|ref|XP_008197892.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.25259 BP_3 262.27 12.70 1287 642929434 XP_008195838.1 963 1.8e-101 PREDICTED: transcription initiation factor TFIID subunit 8-like [Tribolium castaneum]>gi|270010530|gb|EFA06978.1| hypothetical protein TcasGA2_TC009938 [Tribolium castaneum] -- -- -- -- -- K14649 TAF8 transcription initiation factor TFIID subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14649 Q9VWY6 520 1.7e-51 Transcription initiation factor TFIID subunit 8 OS=Drosophila melanogaster GN=Taf8 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2526 BP_3 64.00 1.19 2888 642923363 XP_008193718.1 2243 1.5e-249 PREDICTED: kinesin-like protein KIF14 [Tribolium castaneum]>gi|270008161|gb|EFA04609.1| nebbish [Tribolium castaneum] -- -- -- -- -- K17915 KIF14 kinesin family member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K17915 L0N7N1 920 1.6e-97 Kinesin-like protein KIF14 OS=Mus musculus GN=Kif14 PE=1 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0000166//GO:0003777//GO:0005524 microtubule binding//nucleotide binding//microtubule motor activity//ATP binding GO:0043234//GO:0045298//GO:0015630//GO:0044430//GO:0005874 protein complex//tubulin complex//microtubule cytoskeleton//cytoskeletal part//microtubule KOG0241 Kinesin-like protein Cluster-8309.25260 BP_3 205.05 4.22 2636 189235061 XP_001814285.1 1484 1.4e-161 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1YF12 319 7.2e-28 Zinc finger protein 16 OS=Gorilla gorilla gorilla GN=ZNF16 PE=3 SV=1 PF13465//PF00096//PF10588 Zinc-finger double domain//Zinc finger, C2H2 type//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114 oxidation-reduction process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.25261 BP_3 45.14 0.84 2891 189235061 XP_001814285.1 835 2.8e-86 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61751 217 5.3e-16 Zinc finger protein 354A OS=Mus musculus GN=Znf354a PE=2 SV=2 PF13912//PF01096//PF13465//PF00096 C2H2-type zinc finger//Transcription factor S-II (TFIIS)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006351 transcription, DNA-templated GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.25265 BP_3 1.00 27.20 219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25266 BP_3 117.00 5.02 1414 270010967 EFA07415.1 1039 3.0e-110 brain peptide ITGQGNRIF-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P85828 675 2.0e-69 Prohormone-3 OS=Apis mellifera PE=1 SV=1 PF04706//PF07740 Dickkopf N-terminal cysteine-rich region//Ion channel inhibitory toxin GO:0006810//GO:0007275//GO:0030178//GO:0009405 transport//multicellular organismal development//negative regulation of Wnt signaling pathway//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.25267 BP_3 347.07 4.89 3715 642934618 XP_008197739.1 2979 0.0e+00 PREDICTED: zinc finger protein 62-like [Tribolium castaneum]>gi|270013744|gb|EFA10192.1| hypothetical protein TcasGA2_TC012384 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05481 443 4.2e-42 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25269 BP_3 465.49 22.19 1303 642911417 XP_008199414.1 1498 1.7e-163 PREDICTED: arrestin domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911416 XM_008201192.1 317 3.50753e-163 PREDICTED: Tribolium castaneum arrestin domain-containing protein 2 (LOC661443), transcript variant X1, mRNA -- -- -- -- Q8TBH0 268 2.9e-22 Arrestin domain-containing protein 2 OS=Homo sapiens GN=ARRDC2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.2527 BP_3 11.00 2.14 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25270 BP_3 3345.44 138.50 1456 270297178 NP_001161915.1 962 2.7e-101 cuticular protein analogous to peritrophins 3-E [Tribolium castaneum]>gi|268309024|gb|ACY95478.1| cuticular protein analogous to peritrophins 3-E [Tribolium castaneum]>gi|270001058|gb|EEZ97505.1| hypothetical protein TcasGA2_TC011349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8XWX5 163 4.9e-10 Chondroitin proteoglycan 2 OS=Caenorhabditis briggsae GN=cpg-2 PE=3 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.25271 BP_3 18.06 0.43 2302 642927688 XP_008196543.1 168 4.9e-09 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2528 BP_3 10.00 0.34 1705 478253720 ENN74019.1 1319 1.3e-142 hypothetical protein YQE_09409, partial [Dendroctonus ponderosae]>gi|546685011|gb|ERL94576.1| hypothetical protein D910_11853 [Dendroctonus ponderosae] -- -- -- -- -- K15102 SLC25A3, PHC, PIC solute carrier family 25 (mitochondrial phosphate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15102 P12234 1093 8.3e-118 Phosphate carrier protein, mitochondrial OS=Bos taurus GN=SLC25A3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0767 Mitochondrial phosphate carrier protein Cluster-8309.25281 BP_3 4312.73 104.13 2288 642920410 XP_008192336.1 513 4.9e-49 PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum]>gi|642920412|ref|XP_008192337.1| PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum]>gi|642920414|ref|XP_008192338.1| PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25282 BP_3 237.75 2.18 5545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25283 BP_3 828.50 4.35 9473 642920416 XP_008192339.1 233 5.9e-16 PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03325 Herpesvirus polymerase accessory protein GO:0006260//GO:0019079 DNA replication//viral genome replication GO:0030337 DNA polymerase processivity factor activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.25285 BP_3 140.08 1.07 6628 675379920 KFM72822.1 1258 5.8e-135 Transposable element P transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF08558//PF07967 THAP domain//Telomere repeat binding factor (TRF)//C3HC zinc finger-like -- -- GO:0042162//GO:0003676//GO:0042803//GO:0008270 telomeric DNA binding//nucleic acid binding//protein homodimerization activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25286 BP_3 192.00 36.96 542 642920788 XP_008192561.1 402 8.5e-37 PREDICTED: cholinephosphotransferase 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q4KLV1 262 6.0e-22 Cholinephosphotransferase 1 OS=Xenopus laevis GN=chpt1 PE=2 SV=1 PF01066 CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0016780 phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.25287 BP_3 63.76 1.24 2774 91086463 XP_969857.1 1953 6.2e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1236 3.5e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.25289 BP_3 37.98 0.91 2306 642928571 XP_008199962.1 982 2.0e-103 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q7ZV22 906 5.4e-96 S-methyl-5'-thioadenosine phosphorylase OS=Danio rerio GN=mtap PE=2 SV=2 PF09242//PF01048 Flavocytochrome c sulphide dehydrogenase, flavin-binding//Phosphorylase superfamily GO:0055114//GO:0009116 oxidation-reduction process//nucleoside metabolic process GO:0016491//GO:0003824//GO:0050660 oxidoreductase activity//catalytic activity//flavin adenine dinucleotide binding -- -- KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.2529 BP_3 118.80 9.72 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25290 BP_3 16.00 0.64 1494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25291 BP_3 39.90 0.89 2457 91087699 XP_974256.1 900 6.9e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 4.8e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008417//GO:0016740 fucosyltransferase activity//transferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.25292 BP_3 108.08 1.52 3725 270001422 EEZ97869.1 1064 1.0e-112 hypothetical protein TcasGA2_TC000244 [Tribolium castaneum] 642914786 XM_008192130.1 634 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X7, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 O43679 846 7.9e-89 LIM domain-binding protein 2 OS=Homo sapiens GN=LDB2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.25293 BP_3 211.34 7.92 1578 646696178 KDR08625.1 1853 1.4e-204 LIM domain-binding protein 2, partial [Zootermopsis nevadensis] 642914784 XM_008192129.1 618 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X6, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 Q9W676 1343 7.9e-147 LIM domain-binding protein 2 OS=Gallus gallus GN=LDB2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.25296 BP_3 13.00 0.79 1084 546679237 ERL89731.1 483 6.9e-46 hypothetical protein D910_07092 [Dendroctonus ponderosae] 755973707 XM_011308799.1 91 1.24714e-37 PREDICTED: Fopius arisanus dual specificity mitogen-activated protein kinase kinase 4-like (LOC105268902), mRNA K04430 MAP2K4, MKK4 mitogen-activated protein kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04430 P47809 428 6.8e-41 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 Cluster-8309.25299 BP_3 215.92 6.62 1863 642927330 XP_008195223.1 1284 1.6e-138 PREDICTED: STE20-related kinase adapter protein alpha [Tribolium castaneum] -- -- -- -- -- K08271 STRADA, LYK5 STE20-related kinase adapter protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08271 Q5ZK47 623 2.9e-63 STE20-related kinase adapter protein alpha OS=Gallus gallus GN=STRADA PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0582 Ste20-like serine/threonine protein kinase Cluster-8309.253 BP_3 23.00 0.69 1890 642933863 XP_008197542.1 483 1.2e-45 PREDICTED: 5-hydroxytryptamine receptor-like [Tribolium castaneum] 170035303 XM_001845458.1 80 2.86946e-31 Culex quinquefasciatus 5-hydroxytryptamine receptor 2B, mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q17239 318 6.7e-28 5-hydroxytryptamine receptor OS=Bombyx mori PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.2530 BP_3 67.00 14.65 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25300 BP_3 78.58 1.13 3645 91085763 XP_974155.1 1774 4.7e-195 PREDICTED: polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270009999|gb|EFA06447.1| hypothetical protein TcasGA2_TC009329 [Tribolium castaneum] -- -- -- -- -- K00962 pnp, PNPT1 polyribonucleotide nucleotidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00962 Q8K1R3 1204 2.4e-130 Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Mus musculus GN=Pnpt1 PE=1 SV=1 PF00013//PF00575//PF03726//PF03171 KH domain//S1 RNA binding domain//Polyribonucleotide nucleotidyltransferase, RNA binding domain//2OG-Fe(II) oxygenase superfamily GO:0006402//GO:0006144//GO:0006206//GO:0051252//GO:0006396//GO:0055114 mRNA catabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//regulation of RNA metabolic process//RNA processing//oxidation-reduction process GO:0000175//GO:0003723//GO:0004654//GO:0016491//GO:0003676 3'-5'-exoribonuclease activity//RNA binding//polyribonucleotide nucleotidyltransferase activity//oxidoreductase activity//nucleic acid binding -- -- KOG1067 Predicted RNA-binding polyribonucleotide nucleotidyltransferase Cluster-8309.25302 BP_3 588.49 7.21 4227 642918990 XP_008191687.1 2720 1.1e-304 PREDICTED: tyrosine-protein kinase Btk29A isoform X1 [Tribolium castaneum]>gi|270005708|gb|EFA02156.1| hypothetical protein TcasGA2_TC007809 [Tribolium castaneum] 642918993 XM_008193468.1 431 0 PREDICTED: Tribolium castaneum tyrosine-protein kinase Btk29A (LOC663266), transcript variant X3, mRNA K07364 TEC tyrosine-protein kinase Tec http://www.genome.jp/dbget-bin/www_bget?ko:K07364 P08630 1986 5.8e-221 Tyrosine-protein kinase Btk29A OS=Drosophila melanogaster GN=Btk29A PE=2 SV=2 PF00779//PF00069//PF14604//PF00018//PF07714 BTK motif//Protein kinase domain//Variant SH3 domain//SH3 domain//Protein tyrosine kinase GO:0006468//GO:0035556 protein phosphorylation//intracellular signal transduction GO:0004713//GO:0005524//GO:0005543//GO:0005515//GO:0004672 protein tyrosine kinase activity//ATP binding//phospholipid binding//protein binding//protein kinase activity GO:0005622 intracellular -- -- Cluster-8309.25303 BP_3 28.00 6.66 494 270015441 EFA11889.1 233 3.1e-17 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25305 BP_3 11.29 0.37 1760 642910205 XP_008198403.1 337 9.6e-29 PREDICTED: NF-kappa-B-repressing factor-like [Tribolium castaneum]>gi|270014634|gb|EFA11082.1| hypothetical protein TcasGA2_TC004678 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15226 145 7.2e-08 NF-kappa-B-repressing factor OS=Homo sapiens GN=NKRF PE=1 SV=2 PF01424//PF01585 R3H domain//G-patch domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.25306 BP_3 48.59 1.66 1702 642910205 XP_008198403.1 352 1.7e-30 PREDICTED: NF-kappa-B-repressing factor-like [Tribolium castaneum]>gi|270014634|gb|EFA11082.1| hypothetical protein TcasGA2_TC004678 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15226 145 7.0e-08 NF-kappa-B-repressing factor OS=Homo sapiens GN=NKRF PE=1 SV=2 PF01585//PF01424 G-patch domain//R3H domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.25309 BP_3 28.99 2.89 776 332373772 AEE62027.1 692 2.9e-70 unknown [Dendroctonus ponderosae]>gi|478252497|gb|ENN72919.1| hypothetical protein YQE_10486, partial [Dendroctonus ponderosae]>gi|546679961|gb|ERL90331.1| hypothetical protein D910_07680 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16326//PF05531//PF04353//PF05837//PF08702 ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family GO:0006355//GO:0030168//GO:0007165//GO:0051382//GO:0051258 regulation of transcription, DNA-templated//platelet activation//signal transduction//kinetochore assembly//protein polymerization GO:0030674//GO:0005102//GO:0003677 protein binding, bridging//receptor binding//DNA binding GO:0000776//GO:0005577//GO:0019028 kinetochore//fibrinogen complex//viral capsid -- -- Cluster-8309.25310 BP_3 274.01 31.35 713 332373772 AEE62027.1 664 4.7e-67 unknown [Dendroctonus ponderosae]>gi|478252497|gb|ENN72919.1| hypothetical protein YQE_10486, partial [Dendroctonus ponderosae]>gi|546679961|gb|ERL90331.1| hypothetical protein D910_07680 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702//PF04353//PF05837//PF05531//PF16326 Fibrinogen alpha/beta chain family//Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ//Centromere protein H (CENP-H)//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain GO:0007165//GO:0051382//GO:0051258//GO:0030168//GO:0006355 signal transduction//kinetochore assembly//protein polymerization//platelet activation//regulation of transcription, DNA-templated GO:0003677//GO:0005102//GO:0030674 DNA binding//receptor binding//protein binding, bridging GO:0019028//GO:0000776//GO:0005577 viral capsid//kinetochore//fibrinogen complex -- -- Cluster-8309.25314 BP_3 83.48 1.08 4033 642936684 XP_001807897.2 1937 6.5e-214 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] 755863466 XM_005179480.2 52 2.27074e-15 PREDICTED: Musca domestica uncharacterized LOC101889854 (LOC101889854), mRNA -- -- -- -- Q23435 273 2.4e-22 TWiK family of potassium channels protein 9 OS=Caenorhabditis elegans GN=twk-9 PE=2 SV=2 PF01007//PF00520 Inward rectifier potassium channel//Ion transport protein GO:0055085//GO:0006813//GO:0006811 transmembrane transport//potassium ion transport//ion transport GO:0005242//GO:0005216 inward rectifier potassium channel activity//ion channel activity GO:0016021//GO:0016020//GO:0008076 integral component of membrane//membrane//voltage-gated potassium channel complex -- -- Cluster-8309.25315 BP_3 20.22 1.45 964 270013109 EFA09557.1 373 3.5e-33 hypothetical protein TcasGA2_TC011669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02059 Interleukin-3 GO:0006955//GO:0008283//GO:0040007//GO:0007165 immune response//cell proliferation//growth//signal transduction GO:0005135//GO:0008083 interleukin-3 receptor binding//growth factor activity GO:0005576//GO:0005894 extracellular region//interleukin-3 receptor complex -- -- Cluster-8309.25316 BP_3 434.67 12.30 1995 332375789 AEE63035.1 1293 1.5e-139 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DJ55 342 1.2e-30 Protein TBRG4 OS=Xenopus tropicalis GN=tbrg4 PE=2 SV=2 PF06743 FAST kinase-like protein, subdomain 1 -- -- GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.25317 BP_3 22.82 0.83 1615 642936684 XP_001807897.2 994 5.8e-105 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] 755863466 XM_005179480.2 52 8.97899e-16 PREDICTED: Musca domestica uncharacterized LOC101889854 (LOC101889854), mRNA -- -- -- -- Q18120 259 4.0e-21 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF01007//PF00060//PF00520 Inward rectifier potassium channel//Ligand-gated ion channel//Ion transport protein GO:0007268//GO:0006813//GO:0007165//GO:0055085//GO:0006811 synaptic transmission//potassium ion transport//signal transduction//transmembrane transport//ion transport GO:0005242//GO:0004970//GO:0005216 inward rectifier potassium channel activity//ionotropic glutamate receptor activity//ion channel activity GO:0016021//GO:0008076//GO:0016020 integral component of membrane//voltage-gated potassium channel complex//membrane -- -- Cluster-8309.25318 BP_3 35.33 1.04 1932 332375789 AEE63035.1 1290 3.3e-139 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DJ55 342 1.1e-30 Protein TBRG4 OS=Xenopus tropicalis GN=tbrg4 PE=2 SV=2 PF06743 FAST kinase-like protein, subdomain 1 -- -- GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.25319 BP_3 354.03 4.87 3795 91079026 XP_974912.1 1817 5.0e-200 PREDICTED: rap1 GTPase-GDP dissociation stimulator 1-B [Tribolium castaneum]>gi|270003670|gb|EFA00118.1| hypothetical protein TcasGA2_TC002934 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52306 590 3.9e-59 Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens GN=RAP1GDS1 PE=1 SV=3 PF00514//PF11698 Armadillo/beta-catenin-like repeat//V-ATPase subunit H GO:0015991 ATP hydrolysis coupled proton transport GO:0005515//GO:0016820 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.25320 BP_3 10.89 0.45 1460 642910332 XP_008200286.1 1113 8.3e-119 PREDICTED: threonylcarbamoyladenosine tRNA methylthiotransferase [Tribolium castaneum]>gi|270014918|gb|EFA11366.1| hypothetical protein TcasGA2_TC011523 [Tribolium castaneum] -- -- -- -- -- K15865 CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15865 Q291H5 922 4.8e-98 Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Drosophila pseudoobscura pseudoobscura GN=GA19679 PE=3 SV=1 PF00919//PF04055//PF05818//PF02627 Uncharacterized protein family UPF0004//Radical SAM superfamily//Enterobacterial TraT complement resistance protein//Carboxymuconolactone decarboxylase family GO:0055114//GO:0009451//GO:0046999 oxidation-reduction process//RNA modification//regulation of conjugation GO:0051539//GO:0051536//GO:0051920//GO:0016740//GO:0003824 4 iron, 4 sulfur cluster binding//iron-sulfur cluster binding//peroxiredoxin activity//transferase activity//catalytic activity GO:0019867 outer membrane KOG2492 CDK5 activator-binding protein Cluster-8309.25321 BP_3 1.21 0.32 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25322 BP_3 42.00 2.74 1031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25323 BP_3 36.92 0.93 2198 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25324 BP_3 9.66 0.50 1215 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25326 BP_3 21.00 6.67 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25327 BP_3 4.33 12.13 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25328 BP_3 17.00 0.65 1551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25330 BP_3 64.00 3.59 1151 478252954 ENN73338.1 702 3.0e-71 hypothetical protein YQE_10099, partial [Dendroctonus ponderosae]>gi|546679636|gb|ERL90067.1| hypothetical protein D910_07423 [Dendroctonus ponderosae] -- -- -- -- -- K09341 MSX homeobox protein MSX http://www.genome.jp/dbget-bin/www_bget?ko:K09341 Q03372 379 3.5e-35 Muscle segmentation homeobox OS=Drosophila melanogaster GN=Dr PE=2 SV=2 PF00046//PF10538//PF05920//PF03896 Homeobox domain//Immunoreceptor tyrosine-based activation motif//Homeobox KN domain//Translocon-associated protein (TRAP), alpha subunit GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005789 endoplasmic reticulum membrane KOG0492 Transcription factor MSH, contains HOX domain Cluster-8309.25331 BP_3 657.70 8.52 4013 91082903 XP_972273.1 1219 1.2e-130 PREDICTED: uncharacterized protein LOC660988 isoform X1 [Tribolium castaneum]>gi|270007611|gb|EFA04059.1| hypothetical protein TcasGA2_TC014292 [Tribolium castaneum] -- -- -- -- -- K16731 GOLGA1 golgin subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16731 Q92805 321 6.4e-28 Golgin subfamily A member 1 OS=Homo sapiens GN=GOLGA1 PE=1 SV=3 PF01465//PF04111//PF08988 GRIP domain//Autophagy protein Apg6//Type III secretion system, cytoplasmic E component of needle GO:0006914//GO:0000042//GO:0009405 autophagy//protein targeting to Golgi//pathogenesis GO:0005515 protein binding -- -- -- -- Cluster-8309.25337 BP_3 78.98 2.33 1927 642923162 XP_968605.2 1657 9.1e-182 PREDICTED: O-glucosyltransferase rumi homolog [Tribolium castaneum]>gi|270007100|gb|EFA03548.1| hypothetical protein TcasGA2_TC013552 [Tribolium castaneum] -- -- -- -- -- K13667 RUMI, KTELC1 protein glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13667 Q16QY8 1268 4.8e-138 O-glucosyltransferase rumi homolog OS=Aedes aegypti GN=AAEL011121 PE=3 SV=1 PF08152 GUCT (NUC152) domain -- -- GO:0005524//GO:0004386//GO:0003723 ATP binding//helicase activity//RNA binding GO:0005634 nucleus KOG2458 Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif Cluster-8309.25341 BP_3 19.36 4.25 511 189239014 XP_974755.2 425 1.7e-39 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 178 3.1e-12 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25349 BP_3 44.29 0.43 5234 91083351 XP_975052.1 1345 3.7e-145 PREDICTED: gamma-tubulin complex component 3 [Tribolium castaneum]>gi|270007769|gb|EFA04217.1| hypothetical protein TcasGA2_TC014466 [Tribolium castaneum] -- -- -- -- -- K16570 TUBGCP3, GCP3 gamma-tubulin complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16570 P58854 767 1.6e-79 Gamma-tubulin complex component 3 OS=Mus musculus GN=Tubgcp3 PE=2 SV=2 PF04130 Spc97 / Spc98 family GO:0090063//GO:0000226//GO:0007020 positive regulation of microtubule nucleation//microtubule cytoskeleton organization//microtubule nucleation -- -- GO:0005815//GO:0000922 microtubule organizing center//spindle pole KOG2000 Gamma-tubulin complex, DGRIP91/SPC98 component Cluster-8309.25351 BP_3 5.00 0.92 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25353 BP_3 58.42 1.59 2061 642919443 XP_974536.2 1684 7.2e-185 PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum]>gi|642919445|ref|XP_008191871.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum] 158299880 XM_319893.4 393 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1509 5.8e-166 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF06221//PF08168//PF00270 Putative zinc finger motif, C2HC5-type//NUC205 domain//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0005524//GO:0003676 zinc ion binding//ATP binding//nucleic acid binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.25357 BP_3 779.06 9.49 4248 642912669 XP_008200957.1 3277 0.0e+00 PREDICTED: aminopeptidase N [Tribolium castaneum] 556957556 XM_005989784.1 42 8.66746e-10 PREDICTED: Latimeria chalumnae alanyl (membrane) aminopeptidase (ANPEP), transcript variant X3, mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1579 9.1e-174 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.25361 BP_3 427.39 3.77 5761 478261413 ENN80790.1 311 3.2e-25 hypothetical protein YQE_02799, partial [Dendroctonus ponderosae]>gi|546680986|gb|ERL91160.1| hypothetical protein D910_08500 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14895//PF07578 Protein phosphatase 1 inhibitor//Lipid A Biosynthesis N-terminal domain GO:0009245//GO:0010923 lipid A biosynthetic process//negative regulation of phosphatase activity GO:0008915//GO:0019902 lipid-A-disaccharide synthase activity//phosphatase binding -- -- -- -- Cluster-8309.25363 BP_3 104.89 0.92 5776 478261413 ENN80790.1 312 2.5e-25 hypothetical protein YQE_02799, partial [Dendroctonus ponderosae]>gi|546680986|gb|ERL91160.1| hypothetical protein D910_08500 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07578//PF14895 Lipid A Biosynthesis N-terminal domain//Protein phosphatase 1 inhibitor GO:0010923//GO:0009245 negative regulation of phosphatase activity//lipid A biosynthetic process GO:0008915//GO:0019902 lipid-A-disaccharide synthase activity//phosphatase binding -- -- -- -- Cluster-8309.25365 BP_3 57.08 4.77 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25370 BP_3 131.44 39.67 451 546683852 ERL93605.1 483 2.9e-46 hypothetical protein D910_10893 [Dendroctonus ponderosae] -- -- -- -- -- K02956 RP-S15, MRPS15, rpsO small subunit ribosomal protein S15 http://www.genome.jp/dbget-bin/www_bget?ko:K02956 Q8WTC1 433 7.4e-42 28S ribosomal protein S15, mitochondrial OS=Drosophila melanogaster GN=bonsai PE=2 SV=2 PF05531//PF00312 Nucleopolyhedrovirus P10 protein//Ribosomal protein S15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0019028//GO:0005840 intracellular//viral capsid//ribosome -- -- Cluster-8309.25371 BP_3 32.12 0.75 2350 646719839 KDR21809.1 189 1.9e-11 hypothetical protein L798_02611, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P42283 143 1.6e-07 Longitudinals lacking protein, isoform G OS=Drosophila melanogaster GN=lola PE=1 SV=2 PF02150//PF00096//PF02176//PF02701//PF13465//PF16622//PF02892 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//TRAF-type zinc finger//Dof domain, zinc finger//Zinc-finger double domain//zinc-finger C2H2-type//BED zinc finger GO:0006351//GO:0006144//GO:0006355//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//zinc ion binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.25372 BP_3 11.00 0.80 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25375 BP_3 242.09 4.38 2956 642933785 XP_008197283.1 3611 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933787|ref|XP_008197292.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933789|ref|XP_008197304.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2199 8.1e-246 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF00437//PF03193//PF00005//PF13304//PF01926//PF00664//PF01637 Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Archaeal ATPase GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.25376 BP_3 21.00 1.03 1272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25377 BP_3 178.43 1.21 7375 642929299 XP_008195778.1 5901 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 4266 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF00647//PF10152//PF00223//PF08040 Elongation factor 1 gamma, conserved domain//Predicted coiled-coil domain-containing protein (DUF2360)//Photosystem I psaA/psaB protein//MNLL subunit GO:0006118//GO:0006448//GO:0006414//GO:0015979 obsolete electron transport//regulation of translational elongation//translational elongation//photosynthesis GO:0003746//GO:0003954 translation elongation factor activity//NADH dehydrogenase activity GO:0071203//GO:0009579//GO:0005739//GO:0005840//GO:0009522//GO:0016021 WASH complex//thylakoid//mitochondrion//ribosome//photosystem I//integral component of membrane KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.25378 BP_3 181.00 51.74 460 546678420 ERL89043.1 260 2.1e-20 hypothetical protein D910_06421 [Dendroctonus ponderosae] -- -- -- -- -- K17436 MRPL55 large subunit ribosomal protein L55 http://www.genome.jp/dbget-bin/www_bget?ko:K17436 Q9VE04 194 3.9e-14 39S ribosomal protein L55, mitochondrial OS=Drosophila melanogaster GN=mRpL55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25379 BP_3 144.77 1.07 6842 91078738 XP_967649.1 297 1.6e-23 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DC39 181 1.9e-11 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.2538 BP_3 5.00 0.31 1062 86515414 NP_001034533.1 476 4.4e-45 asense [Tribolium castaneum]>gi|33621864|gb|AAQ23387.1| Ase [Tribolium castaneum]>gi|270006266|gb|EFA02714.1| hypothetical protein TcasGA2_TC008437 [Tribolium castaneum] -- -- -- -- -- K09067 ASCL achaete-scute complex protein http://www.genome.jp/dbget-bin/www_bget?ko:K09067 P09775 216 2.5e-16 Achaete-scute complex protein T8 OS=Drosophila melanogaster GN=ase PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.25384 BP_3 162.39 2.52 3398 642912272 XP_008200632.1 415 1.7e-37 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P6T1 164 8.7e-10 Complement C1s subcomponent OS=Rattus norvegicus GN=C1s PE=2 SV=2 PF15965//PF00089//PF01414 TRAF-like zinc-finger//Trypsin//Delta serrate ligand GO:0007154//GO:0006508 cell communication//proteolysis GO:0004252//GO:0008270 serine-type endopeptidase activity//zinc ion binding GO:0016020 membrane -- -- Cluster-8309.25385 BP_3 183.00 19.29 749 642912599 XP_008200927.1 269 3.1e-21 PREDICTED: anaphase-promoting complex subunit 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9JSB3 173 1.7e-11 Anaphase-promoting complex subunit 15 OS=Xenopus tropicalis GN=anapc15 PE=2 SV=1 PF06213//PF02724//PF09421//PF15243//PF01080//PF04889//PF06524//PF04147//PF06512//PF04931 Cobalamin biosynthesis protein CobT//CDC45-like protein//Frequency clock protein//Anaphase-promoting complex subunit 15//Presenilin//Cwf15/Cwc15 cell cycle control protein//NOA36 protein//Nop14-like family//Sodium ion transport-associated//DNA polymerase phi GO:0006351//GO:0007623//GO:0006270//GO:0090266//GO:0009236//GO:0000398//GO:0006355//GO:0006814//GO:0006260 transcription, DNA-templated//circadian rhythm//DNA replication initiation//regulation of mitotic cell cycle spindle assembly checkpoint//cobalamin biosynthetic process//mRNA splicing, via spliceosome//regulation of transcription, DNA-templated//sodium ion transport//DNA replication GO:0003887//GO:0005248//GO:0003677//GO:0004190//GO:0008270 DNA-directed DNA polymerase activity//voltage-gated sodium channel activity//DNA binding//aspartic-type endopeptidase activity//zinc ion binding GO:0005681//GO:0005680//GO:0005634//GO:0042575//GO:0001518//GO:0016021//GO:0032040//GO:0005737 spliceosomal complex//anaphase-promoting complex//nucleus//DNA polymerase complex//voltage-gated sodium channel complex//integral component of membrane//small-subunit processome//cytoplasm -- -- Cluster-8309.25387 BP_3 353.00 11.05 1831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25389 BP_3 80.02 1.79 2448 270003145 EEZ99592.1 3383 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.0e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.25392 BP_3 227.00 16.01 975 478255404 ENN75626.1 417 2.8e-38 hypothetical protein YQE_07804, partial [Dendroctonus ponderosae]>gi|546675096|gb|ERL86346.1| hypothetical protein D910_03754 [Dendroctonus ponderosae] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 Q05713 241 2.9e-19 Alpha-crystallin B chain OS=Gallus gallus GN=CRYAB PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25394 BP_3 4.00 0.56 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25395 BP_3 34.00 1.83 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25396 BP_3 27.02 0.56 2617 270003285 EEZ99732.1 1425 9.8e-155 hypothetical protein TcasGA2_TC002501 [Tribolium castaneum] 780625043 XM_011709899.1 203 1.68302e-99 PREDICTED: Wasmannia auropunctata CCR4-NOT transcription complex subunit 3 (LOC105462953), mRNA K12580 CNOT3, NOT3 CCR4-NOT transcription complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12580 O75175 858 2.3e-90 CCR4-NOT transcription complex subunit 3 OS=Homo sapiens GN=CNOT3 PE=1 SV=1 PF04065//PF07352//PF04153 Not1 N-terminal domain, CCR4-Not complex component//Bacteriophage Mu Gam like protein//NOT2 / NOT3 / NOT5 family GO:0006355//GO:0042262 regulation of transcription, DNA-templated//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG2150 CCR4-NOT transcriptional regulation complex, NOT5 subunit Cluster-8309.25397 BP_3 24.96 0.46 2928 270005301 EFA01749.1 1244 1.1e-133 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.2540 BP_3 4.00 10.62 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25404 BP_3 10.02 0.37 1608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00260 Protamine P1 GO:0007283 spermatogenesis GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.25405 BP_3 193.87 12.31 1051 642939916 XP_973092.3 910 2.1e-95 PREDICTED: trafficking protein particle complex subunit 5 [Tribolium castaneum]>gi|270015732|gb|EFA12180.1| hypothetical protein TcasGA2_TC002333 [Tribolium castaneum] 815792880 XM_012361625.1 95 7.2187e-40 PREDICTED: Linepithema humile trafficking protein particle complex subunit 5 (LOC105668927), mRNA -- -- -- -- Q5F359 610 5.2e-62 Trafficking protein particle complex subunit 5 OS=Gallus gallus GN=TRAPPC5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3315 Transport protein particle (TRAPP) complex subunit Cluster-8309.25407 BP_3 29.48 1.58 1189 478259751 ENN79592.1 783 1.2e-80 hypothetical protein YQE_03963, partial [Dendroctonus ponderosae]>gi|546678748|gb|ERL89300.1| hypothetical protein D910_06672 [Dendroctonus ponderosae] -- -- -- -- -- K14302 NUP37 nuclear pore complex protein Nup37 http://www.genome.jp/dbget-bin/www_bget?ko:K14302 Q9CWU9 306 1.0e-26 Nucleoporin Nup37 OS=Mus musculus GN=Nup37 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25408 BP_3 816.19 25.39 1841 546673062 ERL84739.1 1005 3.5e-106 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 464 7.7e-45 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF07859//PF02230//PF00326//PF01764//PF11112//PF03583 alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3)//Pyocin activator protein PrtN//Secretory lipase GO:0046486//GO:0016042//GO:0006508//GO:0006355//GO:0006629//GO:0008152 glycerolipid metabolic process//lipid catabolic process//proteolysis//regulation of transcription, DNA-templated//lipid metabolic process//metabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.25413 BP_3 416.24 13.21 1811 642917373 XP_001806886.2 862 1.3e-89 PREDICTED: N-alpha-acetyltransferase 10 [Tribolium castaneum]>gi|270003017|gb|EEZ99464.1| hypothetical protein TcasGA2_TC000030 [Tribolium castaneum] 675300535 KM377395.1 146 5.61955e-68 Pauropsalta sp. 8 CLO-2014 acetyltransferase (ARD1) gene, partial cds K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 P41227 699 4.3e-72 N-alpha-acetyltransferase 10 OS=Homo sapiens GN=NAA10 PE=1 SV=1 PF12568//PF00583//PF13508//PF08445//PF13302//PF13673 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3235 Subunit of the major N alpha-acetyltransferase Cluster-8309.25417 BP_3 33.36 0.43 3995 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2542 BP_3 616.42 20.26 1758 642922070 XP_008193006.1 379 1.3e-33 PREDICTED: cuticle protein 19-like [Tribolium castaneum]>gi|270008195|gb|EFA04643.1| cuticular protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 283 7.2e-24 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.25421 BP_3 13.00 10.16 348 817061123 XP_012252151.1 212 5.9e-15 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25422 BP_3 1.00 11.75 239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25423 BP_3 54.00 4.57 861 154414548 XP_001580301.1 329 4.0e-28 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121914517|gb|EAY19315.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 270 1.1e-22 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.25424 BP_3 3.00 2.05 358 817061123 XP_012252151.1 200 1.5e-13 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09508 Lacto-N-biose phosphorylase -- -- GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.25425 BP_3 3.78 0.92 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25427 BP_3 4.00 10.34 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25428 BP_3 1.00 27.20 219 817061123 XP_012252151.1 132 6.9e-06 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25429 BP_3 23.65 2.05 847 668448475 KFB38130.1 166 3.1e-09 hypothetical protein ZHAS_00005405 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25430 BP_3 33.00 2.10 1048 817061123 XP_012252151.1 383 2.6e-34 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03193//PF00437 Protein of unknown function, DUF258//Type II/IV secretion system protein GO:0006810 transport GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- -- -- Cluster-8309.25431 BP_3 89.00 2.66 1903 817061123 XP_012252151.1 278 7.2e-22 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00004 ATPase family associated with various cellular activities (AAA) -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.25435 BP_3 11.00 1.17 746 157106769 XP_001649474.1 200 3.1e-13 AAEL014742-PA, partial [Aedes aegypti]>gi|108868779|gb|EAT33004.1| AAEL014742-PA, partial [Aedes aegypti] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q8NB46 162 3.3e-10 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens GN=ANKRD52 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.25436 BP_3 22.00 2.01 818 123471666 XP_001319031.1 245 2.1e-18 inversin protein alternative isoform [Trichomonas vaginalis G3]>gi|121901805|gb|EAY06808.1| inversin protein alternative isoform, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q8NB46 186 5.9e-13 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens GN=ANKRD52 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25437 BP_3 34.00 1.96 1126 123389586 XP_001299746.1 398 5.2e-36 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121880660|gb|EAX86816.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 P16157 323 1.1e-28 Ankyrin-1 OS=Homo sapiens GN=ANK1 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.25438 BP_3 9.00 1.34 616 817061123 XP_012252151.1 236 1.7e-17 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25439 BP_3 25.43 4.71 552 123494860 XP_001326609.1 280 1.2e-22 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q5UPA0 203 4.3e-15 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.2544 BP_3 4091.00 246.09 1093 642923114 XP_008193615.1 892 2.6e-93 PREDICTED: uncharacterized protein LOC103313079 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25443 BP_3 42.36 0.93 2478 642928954 XP_008195631.1 832 5.4e-86 PREDICTED: checkpoint protein HUS1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H0R3 570 5.3e-57 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 PF04005 Hus1-like protein GO:0006281//GO:0000077 DNA repair//DNA damage checkpoint -- -- GO:0030896 checkpoint clamp complex KOG3150 Uncharacterized conserved protein Cluster-8309.25444 BP_3 59.00 3.26 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25445 BP_3 5.00 0.47 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25447 BP_3 604.42 10.66 3024 91083715 XP_970185.1 1499 3.0e-163 PREDICTED: RNA-binding protein 45 [Tribolium castaneum]>gi|270007883|gb|EFA04331.1| hypothetical protein TcasGA2_TC014625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUH3 745 3.3e-77 RNA-binding protein 45 OS=Homo sapiens GN=RBM45 PE=1 SV=1 PF14552//PF16367//PF00076//PF08675//PF08777 Tautomerase enzyme//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain//RNA binding motif GO:0006402//GO:0051252//GO:0006725 mRNA catabolic process//regulation of RNA metabolic process//cellular aromatic compound metabolic process GO:0016853//GO:0003723//GO:0046872//GO:0097159//GO:1901363//GO:0004535//GO:0003676 isomerase activity//RNA binding//metal ion binding//organic cyclic compound binding//heterocyclic compound binding//poly(A)-specific ribonuclease activity//nucleic acid binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.25450 BP_3 37.43 0.98 2140 642916176 XP_008190917.1 2246 5.1e-250 PREDICTED: transcription factor 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BQ70 1132 3.1e-122 Transcription factor 25 OS=Homo sapiens GN=TCF25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2422 Uncharacterized conserved protein Cluster-8309.25454 BP_3 40.95 0.79 2783 642928537 XP_008195365.1 798 5.3e-82 PREDICTED: serine protease easter-like [Tribolium castaneum]>gi|270011008|gb|EFA07456.1| serine protease P95 [Tribolium castaneum] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q7ZWD4 549 1.6e-54 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Danio rerio GN=uap1l1 PE=2 SV=1 PF01704//PF07657//PF00089 UTP--glucose-1-phosphate uridylyltransferase//N terminus of Notch ligand//Trypsin GO:0007275//GO:0007219//GO:0008152//GO:0006508 multicellular organismal development//Notch signaling pathway//metabolic process//proteolysis GO:0070569//GO:0008236//GO:0004252 uridylyltransferase activity//serine-type peptidase activity//serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.25456 BP_3 755.66 34.71 1341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25457 BP_3 3587.00 39.28 4693 270007647 EFA04095.1 2932 0.0e+00 hypothetical protein TcasGA2_TC014330 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NP60 1712 3.8e-189 MOXD1 homolog 2 OS=Drosophila melanogaster GN=olf413 PE=2 SV=1 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0055114 oxidation-reduction process GO:0004497//GO:0016715//GO:0005507 monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//copper ion binding -- -- KOG3568 Dopamine beta-monooxygenase Cluster-8309.25458 BP_3 178.20 16.97 798 -- -- -- -- -- 642938590 XM_008201633.1 47 2.61387e-13 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF06459 Ryanodine Receptor TM 4-6 GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.25460 BP_3 277.50 4.67 3157 642932004 XP_008196815.1 2760 1.9e-309 PREDICTED: transducin beta-like protein 3 [Tribolium castaneum]>gi|270012271|gb|EFA08719.1| hypothetical protein TcasGA2_TC006390 [Tribolium castaneum] -- -- -- -- -- K14555 UTP13, TBL3 U3 small nucleolar RNA-associated protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K14555 Q5U2W5 1299 2.0e-141 Transducin beta-like protein 3 OS=Rattus norvegicus GN=Tbl3 PE=2 SV=1 PF08625//PF07569//PF00400 Utp13 specific WD40 associated domain//TUP1-like enhancer of split//WD domain, G-beta repeat GO:0006364//GO:0006355 rRNA processing//regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0032040 nucleus//small-subunit processome KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.25461 BP_3 219.50 3.79 3085 642932004 XP_008196815.1 2720 7.9e-305 PREDICTED: transducin beta-like protein 3 [Tribolium castaneum]>gi|270012271|gb|EFA08719.1| hypothetical protein TcasGA2_TC006390 [Tribolium castaneum] -- -- -- -- -- K14555 UTP13, TBL3 U3 small nucleolar RNA-associated protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K14555 Q5U2W5 1298 2.5e-141 Transducin beta-like protein 3 OS=Rattus norvegicus GN=Tbl3 PE=2 SV=1 PF08625//PF07569//PF00400 Utp13 specific WD40 associated domain//TUP1-like enhancer of split//WD domain, G-beta repeat GO:0006355//GO:0006364 regulation of transcription, DNA-templated//rRNA processing GO:0005515 protein binding GO:0005634//GO:0032040 nucleus//small-subunit processome KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.25462 BP_3 222.16 2.56 4482 642925980 XP_008194717.1 1157 2.0e-123 PREDICTED: sugar phosphate exchanger 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 695 3.1e-71 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF03137//PF07690//PF02293 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily//AmiS/UreI family transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.25464 BP_3 159.99 1.92 4313 642925980 XP_008194717.1 1157 1.9e-123 PREDICTED: sugar phosphate exchanger 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 695 3.0e-71 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF02293//PF07690//PF03137 AmiS/UreI family transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.25465 BP_3 139.75 3.52 2205 642925982 XP_968141.3 966 1.4e-101 PREDICTED: sugar phosphate exchanger 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 608 1.9e-61 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF02293//PF07690 AmiS/UreI family transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.25466 BP_3 24.19 0.33 3780 478257874 ENN78015.1 492 2.2e-46 hypothetical protein YQE_05500, partial [Dendroctonus ponderosae] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q9WU81 371 9.6e-34 Sugar phosphate exchanger 2 OS=Mus musculus GN=Slc37a2 PE=1 SV=1 PF07690//PF02293 Major Facilitator Superfamily//AmiS/UreI family transporter GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.25467 BP_3 76.58 0.91 4335 642931340 XP_008196537.1 877 5.7e-91 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X2 [Tribolium castaneum] 645002817 XM_008209793.1 78 8.59965e-30 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X2, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 702 4.6e-72 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.25470 BP_3 9.06 0.76 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25471 BP_3 7.00 1.00 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25472 BP_3 63.00 1.89 1902 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08302 Fungal tRNA ligase phosphodiesterase domain GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation GO:0005524//GO:0003972 ATP binding//RNA ligase (ATP) activity -- -- -- -- Cluster-8309.25476 BP_3 551.00 13.32 2286 91090334 XP_966832.1 1009 1.5e-106 PREDICTED: uncharacterized protein LOC655224 [Tribolium castaneum]>gi|642934945|ref|XP_008195892.1| PREDICTED: uncharacterized protein LOC655224 [Tribolium castaneum]>gi|270013818|gb|EFA10266.1| hypothetical protein TcasGA2_TC012466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25478 BP_3 1391.00 148.24 744 270009630 EFA06078.1 154 6.7e-08 hypothetical protein TcasGA2_TC008914 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25480 BP_3 171.00 15.26 832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25481 BP_3 67.60 0.87 4056 91079124 XP_975420.1 615 1.3e-60 PREDICTED: proteasome assembly chaperone 2 [Tribolium castaneum]>gi|270003633|gb|EFA00081.1| hypothetical protein TcasGA2_TC002896 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF08052//PF00096//PF07975//PF14735//PF13912//PF07776 Zinc-finger double domain//PyrBI operon leader peptide//Zinc finger, C2H2 type//TFIIH C1-like domain//HAUS augmin-like complex subunit 4//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) GO:0006281//GO:0019856//GO:0051225 DNA repair//pyrimidine nucleobase biosynthetic process//spindle assembly GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0070652//GO:0005634 HAUS complex//nucleus -- -- Cluster-8309.25483 BP_3 2.37 1.50 364 270015441 EFA11889.1 170 4.6e-10 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25484 BP_3 7.00 1.67 494 270015441 EFA11889.1 209 1.9e-14 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25487 BP_3 35.20 0.70 2702 270007326 EFA03774.1 1530 6.8e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 843 1.3e-88 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF08066//PF01612//PF02456 PMC2NT (NUC016) domain//3'-5' exonuclease//Adenovirus IVa2 protein GO:0006396//GO:0006139//GO:0019083 RNA processing//nucleobase-containing compound metabolic process//viral transcription GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.25488 BP_3 219.00 2.82 4029 -- -- -- -- -- 642922128 XM_008194807.1 86 2.85258e-34 PREDICTED: Tribolium castaneum broad-complex core protein isoforms 1/2/3/4/5 (LOC658867), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF00951 Arterivirus GL envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.25489 BP_3 81.64 2.61 1799 91081761 XP_973104.1 642 4.2e-64 PREDICTED: gastrula zinc finger protein XlCGF57.1 isoform X1 [Tribolium castaneum]>gi|642921381|ref|XP_008192843.1| PREDICTED: gastrula zinc finger protein XlCGF57.1 isoform X1 [Tribolium castaneum]>gi|642921383|ref|XP_008192844.1| PREDICTED: gastrula zinc finger protein XlCGF57.1 isoform X1 [Tribolium castaneum]>gi|270006272|gb|EFA02720.1| hypothetical protein TcasGA2_TC008444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25490 BP_3 98.75 1.69 3101 688549951 XP_009298913.1 991 2.5e-104 PREDICTED: zinc finger protein 721-like, partial [Danio rerio] 847046770 XM_012952304.1 39 2.93444e-08 PREDICTED: Jaculus jaculus zinc finger protein 791-like (LOC101594745), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 920 1.7e-97 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF03153//PF16622//PF02487//PF01586//PF00096//PF13465 C2H2-type zinc finger//Transcription factor IIA, alpha/beta subunit//zinc-finger C2H2-type//CLN3 protein//Myogenic Basic domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0007517//GO:0006355//GO:0006367 muscle organ development//regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634//GO:0016020//GO:0005672 nucleus//membrane//transcription factor TFIIA complex -- -- Cluster-8309.25492 BP_3 47.96 1.75 1614 642922123 XP_008193025.1 1626 3.0e-178 PREDICTED: broad-complex core protein isoforms 1/2/3/4/5 isoform X1 [Tribolium castaneum] 642922122 XM_008194803.1 235 1.67422e-117 PREDICTED: Tribolium castaneum broad-complex core protein isoforms 1/2/3/4/5 (LOC658867), transcript variant X1, mRNA -- -- -- -- Q9W0K7 295 2.7e-25 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF02892//PF13912//PF00651//PF01775//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//BTB/POZ domain//Ribosomal L18ae/LX protein domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003677//GO:0046872//GO:0005515 structural constituent of ribosome//DNA binding//metal ion binding//protein binding GO:0005840 ribosome -- -- Cluster-8309.25493 BP_3 83.95 2.69 1798 270008183 EFA04631.1 1602 2.0e-175 chronologically inappropriate morphogenesis [Tribolium castaneum] 642922128 XM_008194807.1 222 3.15024e-110 PREDICTED: Tribolium castaneum broad-complex core protein isoforms 1/2/3/4/5 (LOC658867), transcript variant X4, mRNA -- -- -- -- Q9W0K7 295 3.0e-25 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF00651//PF13912//PF02892//PF00096//PF13465 BTB/POZ domain//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0046872//GO:0005515 DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.25494 BP_3 75.00 1.88 2216 642933721 XP_967531.2 1101 3.1e-117 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY3 673 5.4e-69 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.25495 BP_3 496.89 8.54 3097 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.25496 BP_3 16.00 1.03 1042 389608331 BAM17777.1 365 3.2e-32 ribosomal protein S27 [Papilio xuthus]>gi|389610887|dbj|BAM19054.1| ribosomal protein S27 [Papilio polytes] 697086289 XM_009657762.1 958 0 Verticillium dahliae VdLs.17 40S ribosomal protein S27 mRNA K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 Q7RVN2 431 2.9e-41 40S ribosomal protein S27 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=crp-6 PE=3 SV=1 PF01667 Ribosomal protein S27 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1779 40s ribosomal protein S27 Cluster-8309.25497 BP_3 410.35 3.78 5523 270016078 EFA12526.1 1426 1.6e-154 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] 118441617 CR925768.9 53 8.66706e-16 Zebrafish DNA sequence from clone DKEY-20L4 in linkage group 12, complete sequence -- -- -- -- P0CT34 848 6.9e-89 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF00665//PF02793 Integrase core domain//Hormone receptor domain GO:0015074//GO:0007186 DNA integration//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.25498 BP_3 32.11 1.24 1537 642930251 XP_971223.2 984 7.9e-104 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 132 2.0e-06 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.2550 BP_3 13.00 0.59 1348 675390166 KFM83063.1 517 9.8e-50 hypothetical protein X975_07485, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF03184 PHD-finger//DDE superfamily endonuclease -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- -- -- Cluster-8309.25500 BP_3 1705.99 46.87 2046 91087775 XP_976468.1 584 2.5e-57 PREDICTED: uncharacterized protein LOC663962 [Tribolium castaneum]>gi|642930537|ref|XP_008196446.1| PREDICTED: uncharacterized protein LOC663962 [Tribolium castaneum]>gi|642930539|ref|XP_008196447.1| PREDICTED: uncharacterized protein LOC663962 [Tribolium castaneum]>gi|270010748|gb|EFA07196.1| hypothetical protein TcasGA2_TC010202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25501 BP_3 6.00 0.38 1060 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08720 Influenza C hemagglutinin stalk GO:0019064//GO:0007165 fusion of virus membrane with host plasma membrane//signal transduction GO:0046789 host cell surface receptor binding GO:0019031//GO:0009986 viral envelope//cell surface -- -- Cluster-8309.25502 BP_3 58.00 6.48 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25503 BP_3 75.47 0.75 5159 478250642 ENN71134.1 2677 1.3e-299 hypothetical protein YQE_12065, partial [Dendroctonus ponderosae]>gi|546674775|gb|ERL86072.1| hypothetical protein D910_03486 [Dendroctonus ponderosae] -- -- -- -- -- K03028 PSMD2, RPN1 26S proteasome regulatory subunit N1 http://www.genome.jp/dbget-bin/www_bget?ko:K03028 Q13200 1987 5.4e-221 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 PF12937//PF00328 F-box-like//Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515 acid phosphatase activity//protein binding -- -- KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2 Cluster-8309.25504 BP_3 12.62 0.53 1447 662191266 XP_008468441.1 664 9.5e-67 PREDICTED: transposable element P transposase [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7M3K2 345 3.8e-31 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.25506 BP_3 174.21 2.37 3830 307170013 EFN62483.1 873 1.5e-90 Transposable element P transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q7M3K2 459 6.1e-44 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25511 BP_3 110.66 0.68 8129 478251011 ENN71492.1 1218 3.1e-130 hypothetical protein YQE_11788, partial [Dendroctonus ponderosae] -- -- -- -- -- K09592 EGLN, HPH hypoxia-inducible factor prolyl hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K09592 Q91YE3 670 4.4e-68 Egl nine homolog 1 OS=Mus musculus GN=Egln1 PE=2 SV=2 PF14659//PF13640 Phage integrase, N-terminal SAM-like domain//2OG-Fe(II) oxygenase superfamily GO:0055114//GO:0015074 oxidation-reduction process//DNA integration GO:0016491//GO:0003677 oxidoreductase activity//DNA binding -- -- KOG3710 EGL-Nine (EGLN) protein Cluster-8309.25514 BP_3 1.05 0.78 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25516 BP_3 283.53 2.73 5294 642936096 XP_008198301.1 3129 0.0e+00 PREDICTED: PR domain zinc finger protein 10-like isoform X2 [Tribolium castaneum] 780701311 XM_011703805.1 79 2.9244e-30 PREDICTED: Wasmannia auropunctata PR domain zinc finger protein 10-like (LOC105458476), transcript variant X2, mRNA -- -- -- -- Q5RAX9 917 6.6e-97 PR domain zinc finger protein 10 OS=Pongo abelii GN=PRDM10 PE=2 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25518 BP_3 3.00 0.31 759 642917011 XP_008199595.1 327 5.9e-28 PREDICTED: probable ATP-dependent RNA helicase DHX35 [Tribolium castaneum] -- -- -- -- -- K13117 DHX35 ATP-dependent RNA helicase DDX35 http://www.genome.jp/dbget-bin/www_bget?ko:K13117 Q5RBD4 260 1.4e-21 Probable ATP-dependent RNA helicase DHX35 OS=Pongo abelii GN=DHX35 PE=2 SV=1 PF00270 DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676 ATP binding//nucleic acid binding -- -- KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.25519 BP_3 506.52 5.01 5167 642930342 XP_008196356.1 1185 1.3e-126 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 374 0 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- Q8IUD2 301 1.7e-25 ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens GN=ERC1 PE=1 SV=1 PF06156//PF16331//PF05550//PF00901//PF10174//PF07195//PF10473//PF07989//PF03836//PF08657 Protein of unknown function (DUF972)//TolA binding protein trimerisation//Pestivirus Npro endopeptidase C53//Orbivirus outer capsid protein VP5//RIM-binding protein of the cytomatrix active zone//Flagellar hook-associated protein 2 C-terminus//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//RasGAP C-terminus//DASH complex subunit Spc34 GO:0007155//GO:0007264//GO:0016032//GO:0008608//GO:0019082//GO:0006260//GO:0070206 cell adhesion//small GTPase mediated signal transduction//viral process//attachment of spindle microtubules to kinetochore//viral protein processing//DNA replication//protein trimerization GO:0042803//GO:0005096//GO:0005198//GO:0008134//GO:0045502 protein homodimerization activity//GTPase activator activity//structural molecule activity//transcription factor binding//dynein binding GO:0030286//GO:0005667//GO:0042729//GO:0009288//GO:0048786//GO:0005876//GO:0019028//GO:0005815 dynein complex//transcription factor complex//DASH complex//bacterial-type flagellum//presynaptic active zone//spindle microtubule//viral capsid//microtubule organizing center KOG4809 Rab6 GTPase-interacting protein involved in endosome-to-TGN transport Cluster-8309.25521 BP_3 6.04 0.57 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25527 BP_3 664.16 4.60 7248 478254018 ENN74310.1 6609 0.0e+00 hypothetical protein YQE_09281, partial [Dendroctonus ponderosae] 242005974 XM_002423790.1 223 3.58028e-110 Pediculus humanus corporis jumonji/arid domain-containing protein, putative, mRNA K11446 KDM5, JARID1 histone demethylase JARID1 http://www.genome.jp/dbget-bin/www_bget?ko:K11446 Q9VMJ7 3573 0.0e+00 Lysine-specific demethylase lid OS=Drosophila melanogaster GN=lid PE=1 SV=1 PF08429//PF01388//PF00628 PLU-1-like protein//ARID/BRIGHT DNA binding domain//PHD-finger GO:0055114 oxidation-reduction process GO:0016706//GO:0003677//GO:0005515 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//DNA binding//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.25529 BP_3 114.53 1.09 5356 642929251 XP_008195755.1 2394 8.7e-267 PREDICTED: uncharacterized protein LOC100141810 isoform X2 [Tribolium castaneum] 642929250 XM_008197533.1 85 1.36693e-33 PREDICTED: Tribolium castaneum uncharacterized LOC100141810 (LOC100141810), transcript variant X2, mRNA -- -- -- -- Q2KHR2 365 6.8e-33 DNA-binding protein RFX7 OS=Homo sapiens GN=RFX7 PE=1 SV=1 PF08917//PF06305//PF11857//PF02257 Transforming growth factor beta receptor 2 ectodomain//Protein of unknown function (DUF1049)//Domain of unknown function (DUF3377)//RFX DNA-binding domain GO:0009069//GO:0006468//GO:0016310//GO:0007178//GO:0006355 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0004222//GO:0003677//GO:0046872//GO:0005026 ATP binding//metalloendopeptidase activity//DNA binding//metal ion binding//transforming growth factor beta receptor activity, type II GO:0005887//GO:0016020 integral component of plasma membrane//membrane KOG3712 RFX family transcription factor Cluster-8309.25530 BP_3 490.99 4.57 5472 642929251 XP_008195755.1 2394 8.9e-267 PREDICTED: uncharacterized protein LOC100141810 isoform X2 [Tribolium castaneum] 642929250 XM_008197533.1 85 1.39674e-33 PREDICTED: Tribolium castaneum uncharacterized LOC100141810 (LOC100141810), transcript variant X2, mRNA -- -- -- -- Q2KHR2 365 6.9e-33 DNA-binding protein RFX7 OS=Homo sapiens GN=RFX7 PE=1 SV=1 PF08917//PF11857//PF06305//PF02257 Transforming growth factor beta receptor 2 ectodomain//Domain of unknown function (DUF3377)//Protein of unknown function (DUF1049)//RFX DNA-binding domain GO:0009069//GO:0006468//GO:0016310//GO:0007178//GO:0006355 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0004222//GO:0003677//GO:0046872//GO:0005026 ATP binding//metalloendopeptidase activity//DNA binding//metal ion binding//transforming growth factor beta receptor activity, type II GO:0005887//GO:0016020 integral component of plasma membrane//membrane KOG3712 RFX family transcription factor Cluster-8309.25531 BP_3 41.48 0.54 4003 642929251 XP_008195755.1 992 2.4e-104 PREDICTED: uncharacterized protein LOC100141810 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305//PF11857//PF08917 Protein of unknown function (DUF1049)//Domain of unknown function (DUF3377)//Transforming growth factor beta receptor 2 ectodomain GO:0016310//GO:0009069//GO:0006468//GO:0007178 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0005524//GO:0004222//GO:0046872//GO:0005026 ATP binding//metalloendopeptidase activity//metal ion binding//transforming growth factor beta receptor activity, type II GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.25532 BP_3 195.00 4.57 2350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25533 BP_3 16.11 0.59 1610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25539 BP_3 117.36 3.00 2177 91077698 XP_974838.1 822 6.8e-85 PREDICTED: D-aspartate oxidase [Tribolium castaneum]>gi|270002204|gb|EEZ98651.1| hypothetical protein TcasGA2_TC001179 [Tribolium castaneum] -- -- -- -- -- K00273 DAO, aao D-amino-acid oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00273 Q922Z0 511 3.2e-50 D-aspartate oxidase OS=Mus musculus GN=Ddo PE=2 SV=1 PF00070//PF01266//PF07992 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.25541 BP_3 57.28 0.44 6503 642924251 XP_008194216.1 4280 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] 755881777 XM_005185855.2 54 2.83883e-16 PREDICTED: Musca domestica N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (LOC101896829), transcript variant X1, mRNA K03857 PIGA, GPI3 phosphatidylinositol glycan, class A http://www.genome.jp/dbget-bin/www_bget?ko:K03857 Q64323 859 4.3e-90 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein OS=Mus musculus GN=Piga PE=2 SV=1 PF03790//PF08288//PF05112//PF02196//PF00621 KNOX1 domain//PIGA (GPI anchor biosynthesis)//Baculovirus P47 protein//Raf-like Ras-binding domain//RhoGEF domain GO:0035023//GO:0007165//GO:0046782//GO:0006506//GO:0043087 regulation of Rho protein signal transduction//signal transduction//regulation of viral transcription//GPI anchor biosynthetic process//regulation of GTPase activity GO:0005057//GO:0003677//GO:0005089 receptor signaling protein activity//DNA binding//Rho guanyl-nucleotide exchange factor activity GO:0005634 nucleus KOG1111 N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase Cluster-8309.25542 BP_3 41.10 1.64 1499 642924737 XP_008194418.1 908 5.0e-95 PREDICTED: protein-S-isoprenylcysteine O-methyltransferase [Tribolium castaneum]>gi|270006711|gb|EFA03159.1| hypothetical protein TcasGA2_TC013078 [Tribolium castaneum] 242016078 XM_002428618.1 47 5.00721e-13 Pediculus humanus corporis protein-S-isoprenylcysteine O-methyltransferase, putative, mRNA K00587 ICMT, STE14 protein-S-isoprenylcysteine O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00587 O12947 645 6.5e-66 Protein-S-isoprenylcysteine O-methyltransferase OS=Xenopus laevis GN=icmt PE=2 SV=1 PF04140//PF00951 Isoprenylcysteine carboxyl methyltransferase (ICMT) family//Arterivirus GL envelope glycoprotein GO:0006479//GO:0006481 protein methylation//C-terminal protein methylation GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021//GO:0019031 integral component of membrane//viral envelope KOG2628 Farnesyl cysteine-carboxyl methyltransferase Cluster-8309.25545 BP_3 123.00 8.47 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25546 BP_3 28.00 1.23 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25548 BP_3 9.48 0.32 1713 642923214 XP_008193658.1 489 2.2e-46 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24488 181 4.7e-12 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25550 BP_3 755.09 8.93 4366 91092696 XP_971938.1 4030 0.0e+00 PREDICTED: trafficking protein particle complex subunit 8 [Tribolium castaneum]>gi|270014865|gb|EFA11313.1| hypothetical protein TcasGA2_TC010852 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2L5 1751 1.1e-193 Trafficking protein particle complex subunit 8 OS=Homo sapiens GN=TRAPPC8 PE=1 SV=2 PF13414//PF00515//PF00377//PF13181 TPR repeat//Tetratricopeptide repeat//Prion/Doppel alpha-helical domain//Tetratricopeptide repeat GO:0051260 protein homooligomerization GO:0005515 protein binding GO:0016020 membrane KOG1938 Protein with predicted involvement in meiosis (GSG1) Cluster-8309.25552 BP_3 22.00 0.36 3221 805812284 XP_012147626.1 229 5.8e-16 PREDICTED: putative uncharacterized protein FLJ37770 isoform X1 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q3ZCU0 157 5.4e-09 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25553 BP_3 6.11 0.38 1067 91092940 XP_972197.1 296 3.3e-24 PREDICTED: ubiquitin carboxyl-terminal hydrolase 10 [Tribolium castaneum]>gi|270004786|gb|EFA01234.1| ubiquitin-specific protease [Tribolium castaneum] 769845732 XM_011635837.1 42 2.12704e-10 PREDICTED: Pogonomyrmex barbatus ubiquitin carboxyl-terminal hydrolase 10 (LOC105425187), mRNA K11841 USP10, UBP3 ubiquitin carboxyl-terminal hydrolase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K11841 Q2NL57 183 1.7e-12 Ubiquitin carboxyl-terminal hydrolase 10-A OS=Xenopus laevis GN=usp10-a PE=2 SV=1 -- -- GO:0016579//GO:0006511 protein deubiquitination//ubiquitin-dependent protein catabolic process GO:0008233//GO:0004221 peptidase activity//obsolete ubiquitin thiolesterase activity -- -- KOG1871 Ubiquitin-specific protease Cluster-8309.25558 BP_3 22.22 1.65 941 91082383 XP_968748.1 506 1.3e-48 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 326 4.0e-29 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0017111//GO:0042626 ATP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.2556 BP_3 4.00 2.24 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25560 BP_3 86.00 7.97 812 478259687 ENN79531.1 1023 1.3e-108 hypothetical protein YQE_03994, partial [Dendroctonus ponderosae] 755689104 XM_011281044.1 39 7.45326e-09 PREDICTED: Felis catus ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 877 4.4e-93 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF04851//PF01926//PF16647//PF03193//PF00005//PF01695 AAA domain, putative AbiEii toxin, Type IV TA system//Type III restriction enzyme, res subunit//50S ribosome-binding GTPase//Granulocyte colony-stimulating factor//Protein of unknown function, DUF258//ABC transporter//IstB-like ATP binding protein GO:0007165//GO:0006955 signal transduction//immune response GO:0003677//GO:0016787//GO:0005524//GO:0003924//GO:0005125//GO:0016887//GO:0005525 DNA binding//hydrolase activity//ATP binding//GTPase activity//cytokine activity//ATPase activity//GTP binding GO:0005576 extracellular region -- -- Cluster-8309.25562 BP_3 82.25 0.95 4474 91082383 XP_968748.1 4004 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91660 2692 8.4e-303 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03266//PF03193//PF00005//PF01637//PF00437//PF06414//PF02367//PF03205//PF01580//PF00931//PF01695//PF01926//PF13304//PF00158//PF00664//PF00004 NTPase//Protein of unknown function, DUF258//ABC transporter//Archaeal ATPase//Type II/IV secretion system protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Molybdopterin guanine dinucleotide synthesis protein B//FtsK/SpoIIIE family//NB-ARC domain//IstB-like ATP binding protein//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Sigma-54 interaction domain//ABC transporter transmembrane region//ATPase family associated with various cellular activities (AAA) GO:0002949//GO:0006355//GO:0006777//GO:0009987//GO:0055085//GO:0006810 tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//Mo-molybdopterin cofactor biosynthetic process//cellular process//transmembrane transport//transport GO:0005525//GO:0003677//GO:0043531//GO:0000166//GO:0016301//GO:0016887//GO:0042626//GO:0005524//GO:0098519//GO:0003924//GO:0008134 GTP binding//DNA binding//ADP binding//nucleotide binding//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//GTPase activity//transcription factor binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.25567 BP_3 10.00 3.54 427 478259687 ENN79531.1 503 1.3e-48 hypothetical protein YQE_03994, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 413 1.5e-39 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF01926//PF03193//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Protein of unknown function, DUF258//ABC transporter -- -- GO:0005525//GO:0005524//GO:0016887//GO:0003924 GTP binding//ATP binding//ATPase activity//GTPase activity -- -- -- -- Cluster-8309.2557 BP_3 4.00 1.58 413 411013040 AFV99179.1 616 9.9e-62 autophagy-related protein 8 [Litopenaeus vannamei]>gi|411013042|gb|AFV99180.1| autophagy-related protein 8 [Penaeus monodon] 332348471 HM149771.1 156 3.32158e-74 Eriocheir sinensis gamma-aminobutyric acid receptor associated protein mRNA, complete cds K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 Q8MK68 580 6.1e-59 Gamma-aminobutyric acid receptor-associated protein OS=Oryctolagus cuniculus GN=GABARAP PE=3 SV=1 PF04110 Ubiquitin-like autophagy protein Apg12 GO:0000045 autophagosome assembly -- -- GO:0005737 cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-8309.25571 BP_3 37.83 0.46 4254 478258345 ENN78464.1 1662 5.3e-182 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1145 1.9e-123 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF02367//PF00931//PF13304//PF01926//PF00664//PF00004//PF00437 Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006810//GO:0055085//GO:0002949 transport//transmembrane transport//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0043531//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ADP binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.25572 BP_3 35.37 0.90 2182 642910256 XP_008198577.1 1549 3.4e-169 PREDICTED: protein capicua homolog isoform X3 [Tribolium castaneum] 642910255 XM_008200355.1 135 8.85027e-62 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X3, mRNA -- -- -- -- Q924A2 321 3.5e-28 Protein capicua homolog OS=Mus musculus GN=Cic PE=1 SV=2 PF02687 FtsX-like permease family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.25573 BP_3 199.05 2.12 4820 642929546 XP_008195880.1 444 1.0e-40 PREDICTED: KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.25574 BP_3 150.04 1.66 4659 642929546 XP_008195880.1 448 3.4e-41 PREDICTED: KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0006355//GO:0009271 regulation of transcription, DNA-templated//phage shock -- -- -- -- -- -- Cluster-8309.25575 BP_3 19.79 0.51 2155 189241787 XP_969759.2 1632 8.0e-179 PREDICTED: cell division cycle protein 16 homolog [Tribolium castaneum] -- -- -- -- -- K03353 APC6, CDC16 anaphase-promoting complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03353 Q13042 1075 1.3e-115 Cell division cycle protein 16 homolog OS=Homo sapiens GN=CDC16 PE=1 SV=2 PF13414//PF13176//PF13371//PF13374//PF00515//PF13174//PF04049//PF04097//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Anaphase promoting complex subunit 8 / Cdc23//Nup93/Nic96//Tetratricopeptide repeat GO:0006810//GO:0030071 transport//regulation of mitotic metaphase/anaphase transition GO:0005515 protein binding GO:0005680//GO:0005643 anaphase-promoting complex//nuclear pore KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit Cluster-8309.25577 BP_3 270.10 3.10 4485 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.45702e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 1.9e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186//PF00278 Vacuolar sorting 38 and autophagy-related subunit 14//Pyridoxal-dependent decarboxylase, C-terminal sheet domain GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.25578 BP_3 9.04 4.48 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25582 BP_3 48.57 0.50 4938 189233914 XP_001815926.1 1210 1.6e-129 PREDICTED: gamma-1-syntrophin isoform X2 [Tribolium castaneum]>gi|270014800|gb|EFA11248.1| hypothetical protein TcasGA2_TC010780 [Tribolium castaneum] 642911446 XM_001815874.2 292 1.07039e-148 PREDICTED: Tribolium castaneum gamma-1-syntrophin (LOC659142), transcript variant X2, mRNA -- -- -- -- Q9NSN8 465 1.6e-44 Gamma-1-syntrophin OS=Homo sapiens GN=SNTG1 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005543//GO:0005515 phospholipid binding//protein binding -- -- KOG3549 Syntrophins (type gamma) Cluster-8309.25583 BP_3 1233.43 12.94 4886 642911445 XP_008199426.1 2416 2.2e-269 PREDICTED: gamma-1-syntrophin isoform X1 [Tribolium castaneum] 642911446 XM_001815874.2 550 0 PREDICTED: Tribolium castaneum gamma-1-syntrophin (LOC659142), transcript variant X2, mRNA -- -- -- -- Q9NSN8 885 3.1e-93 Gamma-1-syntrophin OS=Homo sapiens GN=SNTG1 PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3549 Syntrophins (type gamma) Cluster-8309.25584 BP_3 905.69 11.55 4071 642927132 XP_008195151.1 2005 8.5e-222 PREDICTED: far upstream element-binding protein 1 isoform X2 [Tribolium castaneum] 755783784 XM_006939555.2 43 2.30861e-10 PREDICTED: Felis catus far upstream element (FUSE) binding protein 3 (FUBP3), transcript variant X2, mRNA K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 1.0e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF07650//PF00013//PF13014//PF03400//PF13184 KH domain//KH domain//KH domain//IS1 transposase//NusA-like KH domain GO:0006313 transposition, DNA-mediated GO:0003723//GO:0003677//GO:0004803 RNA binding//DNA binding//transposase activity -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.25585 BP_3 11.11 1.22 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25589 BP_3 99.37 1.07 4748 546673579 ERL85150.1 2351 7.5e-262 hypothetical protein D910_02572 [Dendroctonus ponderosae] 381143842 JN171289.1 206 6.5995e-101 Bembidion scopulinum voucher DRMaddison:DNA1282 topoisomerase I gene, partial cds K03163 TOP1 DNA topoisomerase I http://www.genome.jp/dbget-bin/www_bget?ko:K03163 P30189 1983 1.5e-220 DNA topoisomerase 1 OS=Drosophila melanogaster GN=Top1 PE=1 SV=1 PF04659//PF01028//PF02919 Archaeal flagella protein//Eukaryotic DNA topoisomerase I, catalytic core//Eukaryotic DNA topoisomerase I, DNA binding fragment GO:0006265//GO:0097588 DNA topological change//archaeal or bacterial-type flagellum-dependent cell motility GO:0003918//GO:0003917//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA topoisomerase type I activity//DNA binding GO:0005694 chromosome KOG0981 DNA topoisomerase I Cluster-8309.2559 BP_3 4.00 0.88 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25591 BP_3 216.32 5.70 2122 91088121 XP_970262.1 1059 2.2e-112 PREDICTED: ADP-ribose pyrophosphatase, mitochondrial [Tribolium castaneum]>gi|270011859|gb|EFA08307.1| hypothetical protein TcasGA2_TC005943 [Tribolium castaneum] 462283694 APGK01056848.1 68 1.51266e-24 Dendroctonus ponderosae Seq01056858, whole genome shotgun sequence K13988 NUDT9 ADP-ribose pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K13988 Q8BVU5 847 3.5e-89 ADP-ribose pyrophosphatase, mitochondrial OS=Mus musculus GN=Nudt9 PE=2 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4195 Transient receptor potential-related channel 7 Cluster-8309.25592 BP_3 21.76 0.60 2053 478250678 ENN71170.1 579 9.7e-57 hypothetical protein YQE_12100, partial [Dendroctonus ponderosae]>gi|546678636|gb|ERL89218.1| hypothetical protein D910_06592 [Dendroctonus ponderosae] 462283694 APGK01056848.1 68 1.46265e-24 Dendroctonus ponderosae Seq01056858, whole genome shotgun sequence K13988 NUDT9 ADP-ribose pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K13988 Q8BVU5 490 8.3e-48 ADP-ribose pyrophosphatase, mitochondrial OS=Mus musculus GN=Nudt9 PE=2 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4195 Transient receptor potential-related channel 7 Cluster-8309.25596 BP_3 108.00 3.21 1911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25597 BP_3 36.66 0.58 3324 270009903 EFA06351.1 581 9.2e-57 hypothetical protein TcasGA2_TC009226 [Tribolium castaneum] 759079745 XM_011351395.1 136 3.76724e-62 PREDICTED: Cerapachys biroi protein quiver (LOC105286442), transcript variant X2, mRNA -- -- -- -- B5A5T4 523 2.0e-51 Protein quiver OS=Drosophila melanogaster GN=qvr PE=1 SV=2 PF17064//PF01064 Sleepless protein//Activin types I and II receptor domain GO:0032222//GO:0030431//GO:1903818//GO:0009069//GO:0016310//GO:0007178 regulation of synaptic transmission, cholinergic//sleep//positive regulation of voltage-gated potassium channel activity//serine family amino acid metabolic process//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.25598 BP_3 8.01 0.60 935 91087767 XP_975031.1 1019 4.2e-108 PREDICTED: vacuolar protein sorting-associated protein 28 homolog [Tribolium castaneum]>gi|270010745|gb|EFA07193.1| hypothetical protein TcasGA2_TC010199 [Tribolium castaneum] -- -- -- -- -- K12184 VPS28 ESCRT-I complex subunit VPS28 http://www.genome.jp/dbget-bin/www_bget?ko:K12184 Q9V359 845 2.6e-89 Vacuolar protein sorting-associated protein 28 homolog OS=Drosophila melanogaster GN=Vps28 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3284 Vacuolar sorting protein VPS28 Cluster-8309.256 BP_3 1.00 0.47 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2560 BP_3 18.69 0.43 2391 642935089 XP_008197880.1 1650 7.3e-181 PREDICTED: protein scarlet isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45843 1197 1.0e-129 Protein scarlet OS=Drosophila melanogaster GN=st PE=1 SV=3 PF01061//PF13304//PF01926//PF00275//PF06422//PF00005//PF03193//PF00910 ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)//CDR ABC transporter//ABC transporter//Protein of unknown function, DUF258//RNA helicase GO:0006810 transport GO:0005525//GO:0016887//GO:0016765//GO:0003724//GO:0042626//GO:0005524//GO:0003723//GO:0003924 GTP binding//ATPase activity//transferase activity, transferring alkyl or aryl (other than methyl) groups//RNA helicase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//RNA binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.25600 BP_3 582.00 14.50 2227 642929895 XP_008196017.1 1798 4.7e-198 PREDICTED: nucleolar protein 9 [Tribolium castaneum]>gi|270010631|gb|EFA07079.1| hypothetical protein TcasGA2_TC010059 [Tribolium castaneum] -- -- -- -- -- K14790 NOP9 nucleolar protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14790 Q86U38 417 2.6e-39 Nucleolar protein 9 OS=Homo sapiens GN=NOP9 PE=1 SV=1 PF07425//PF00806 Pardaxin//Pumilio-family RNA binding repeat -- -- GO:0003723 RNA binding GO:0005576 extracellular region KOG2188 Predicted RNA-binding protein, contains Pumilio domains Cluster-8309.25601 BP_3 132.58 5.55 1443 195376525 XP_002047047.1 303 6.9e-25 GJ12142 [Drosophila virilis]>gi|194154205|gb|EDW69389.1| GJ12142 [Drosophila virilis] -- -- -- -- -- -- -- -- -- Q61830 238 9.7e-19 Macrophage mannose receptor 1 OS=Mus musculus GN=Mrc1 PE=1 SV=2 PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- KOG4297 C-type lectin Cluster-8309.25602 BP_3 543.80 14.81 2061 91078172 XP_967060.1 1201 7.3e-129 PREDICTED: sorting nexin-27 [Tribolium castaneum]>gi|270001364|gb|EEZ97811.1| hypothetical protein TcasGA2_TC000177 [Tribolium castaneum] -- -- -- -- -- K17936 SNX27 sorting nexin-27 http://www.genome.jp/dbget-bin/www_bget?ko:K17936 Q96L92 734 4.3e-76 Sorting nexin-27 OS=Homo sapiens GN=SNX27 PE=1 SV=2 PF00788//PF03145//PF03219 Ras association (RalGDS/AF-6) domain//Seven in absentia protein family//TLC ATP/ADP transporter GO:0006810//GO:0007165//GO:0007275//GO:0006511 transport//signal transduction//multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0035091//GO:0005524//GO:0005471 phosphatidylinositol binding//ATP binding//ATP:ADP antiporter activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG3784 Sorting nexin protein SNX27 Cluster-8309.25605 BP_3 222.43 7.47 1727 189239711 XP_966387.2 1319 1.3e-142 PREDICTED: carbohydrate sulfotransferase 11 [Tribolium castaneum]>gi|270009383|gb|EFA05831.1| hypothetical protein TcasGA2_TC008615 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P69478 307 1.2e-26 Carbohydrate sulfotransferase 11 OS=Rattus norvegicus GN=Chst11 PE=1 SV=1 PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.25606 BP_3 136.93 13.38 785 751442604 XP_011195955.1 226 3.2e-16 PREDICTED: uncharacterized protein DDB_G0290301 isoform X1 [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q00690 131 1.4e-06 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25607 BP_3 2.00 25.41 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2561 BP_3 293.97 6.96 2329 642935087 XP_008197879.1 2058 3.5e-228 PREDICTED: protein scarlet isoform X1 [Tribolium castaneum]>gi|744677513|gb|AJD07060.1| scarlet [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45843 1544 5.7e-170 Protein scarlet OS=Drosophila melanogaster GN=st PE=1 SV=3 PF00275//PF13304//PF01926//PF01061//PF00910//PF06422//PF03193//PF00005 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter//RNA helicase//CDR ABC transporter//Protein of unknown function, DUF258//ABC transporter GO:0006810 transport GO:0005524//GO:0003723//GO:0003924//GO:0016887//GO:0005525//GO:0042626//GO:0003724//GO:0016765 ATP binding//RNA binding//GTPase activity//ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//RNA helicase activity//transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.25610 BP_3 972.24 14.20 3592 91094115 XP_968023.1 4146 0.0e+00 PREDICTED: exportin-2 [Tribolium castaneum]>gi|270010891|gb|EFA07339.1| hypothetical protein TcasGA2_TC015935 [Tribolium castaneum] 746860322 XM_011062696.1 135 1.46538e-61 PREDICTED: Acromyrmex echinatior exportin-2 (LOC105149943), mRNA K18423 CSE1, CAS, XPO2 exportin-2 (importin alpha re-exporter) http://www.genome.jp/dbget-bin/www_bget?ko:K18423 Q8AY73 3056 0.0e+00 Exportin-2 OS=Oreochromis niloticus GN=cse1l PE=2 SV=1 PF00514//PF08506//PF03378//PF03810//PF08064 Armadillo/beta-catenin-like repeat//Cse1//CAS/CSE protein, C-terminus//Importin-beta N-terminal domain//UME (NUC010) domain GO:0006886//GO:0016310//GO:0009069//GO:0015031 intracellular protein transport//phosphorylation//serine family amino acid metabolic process//protein transport GO:0005515//GO:0008536//GO:0008565//GO:0004674 protein binding//Ran GTPase binding//protein transporter activity//protein serine/threonine kinase activity GO:0005643 nuclear pore KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily) Cluster-8309.25611 BP_3 441.00 10.85 2251 91094243 XP_968493.1 2462 4.8e-275 PREDICTED: gastrulation defective protein 1 homolog [Tribolium castaneum]>gi|270016277|gb|EFA12723.1| hypothetical protein TcasGA2_TC002358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W1J3 1682 5.5e-186 Gastrulation defective protein 1 homolog OS=Drosophila melanogaster GN=CG5543 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0772 Uncharacterized conserved protein, contains WD40 repeat Cluster-8309.25614 BP_3 1635.00 34.64 2567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02123 Viral RNA-directed RNA-polymerase GO:0006351//GO:0006144 transcription, DNA-templated//purine nucleobase metabolic process GO:0003968//GO:0003723 RNA-directed RNA polymerase activity//RNA binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.25619 BP_3 45.12 0.41 5562 642937342 XP_008198796.1 1501 3.2e-163 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b [Tribolium castaneum] -- -- -- -- -- K01128 SMPDL3 sphingomyelin phosphodiesterase acid-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K01128 Q92485 505 4.1e-49 Acid sphingomyelinase-like phosphodiesterase 3b OS=Homo sapiens GN=SMPDL3B PE=2 SV=2 PF00119 ATP synthase A chain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.25621 BP_3 52.57 4.22 892 642936262 XP_008198373.1 1063 3.2e-113 PREDICTED: bifunctional protein NCOAT isoform X1 [Tribolium castaneum]>gi|270014068|gb|EFA10516.1| hypothetical protein TcasGA2_TC012768 [Tribolium castaneum] 830022072 XM_012723671.1 44 1.36574e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 694 8.0e-72 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3698 Hyaluronoglucosaminidase Cluster-8309.25622 BP_3 578.41 2.62 10924 571541195 XP_006569521.1 5346 0.0e+00 PREDICTED: small subunit processome component 20 homolog, partial [Apis mellifera] -- -- -- -- -- K14772 UTP20 U3 small nucleolar RNA-associated protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K14772 Q5XG71 1869 5.5e-207 Small subunit processome component 20 homolog OS=Mus musculus GN=Utp20 PE=2 SV=2 PF02152//PF02985//PF01701//PF07647 Dihydroneopterin aldolase//HEAT repeat//Photosystem I reaction centre subunit IX / PsaJ//SAM domain (Sterile alpha motif) GO:0006760//GO:0046656//GO:0015979 folic acid-containing compound metabolic process//folic acid biosynthetic process//photosynthesis GO:0004150//GO:0005515 dihydroneopterin aldolase activity//protein binding GO:0009522 photosystem I KOG1823 DRIM (Down-regulated in metastasis)-like proteins Cluster-8309.25624 BP_3 17.11 0.45 2142 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25627 BP_3 422.85 16.97 1493 642929611 XP_975458.3 1430 1.5e-155 PREDICTED: lanC-like protein 3 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y0Y7 888 4.3e-94 LanC-like protein 3 homolog OS=Drosophila melanogaster GN=CG2061 PE=2 SV=1 PF04911//PF06662 ATP synthase j chain//D-glucuronyl C5-epimerase C-terminus GO:0015992//GO:0006024//GO:0015986 proton transport//glycosaminoglycan biosynthetic process//ATP synthesis coupled proton transport GO:0016857//GO:0015078 racemase and epimerase activity, acting on carbohydrates and derivatives//hydrogen ion transmembrane transporter activity GO:0045263//GO:0016021 proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane KOG2787 Lanthionine synthetase C-like protein 1 Cluster-8309.25628 BP_3 13.15 0.45 1715 642929611 XP_975458.3 877 2.3e-91 PREDICTED: lanC-like protein 3 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29HZ1 513 1.5e-50 LanC-like protein 3 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA15215 PE=3 SV=1 PF06662//PF04911 D-glucuronyl C5-epimerase C-terminus//ATP synthase j chain GO:0015986//GO:0006024//GO:0015992 ATP synthesis coupled proton transport//glycosaminoglycan biosynthetic process//proton transport GO:0015078//GO:0016857 hydrogen ion transmembrane transporter activity//racemase and epimerase activity, acting on carbohydrates and derivatives GO:0045263//GO:0016021 proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane KOG2787 Lanthionine synthetase C-like protein 1 Cluster-8309.25629 BP_3 580.57 9.79 3151 -- -- -- -- -- 642922625 XM_008195033.1 61 1.75719e-20 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF08001 CMV US GO:0030683 evasion or tolerance by virus of host immune response -- -- GO:0044386 integral to host endoplasmic reticulum membrane -- -- Cluster-8309.25632 BP_3 3.00 1.13 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25634 BP_3 155.70 1.40 5652 642928644 XP_008199718.1 1825 8.8e-201 PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZF3 1247 3.8e-135 Oxysterol-binding protein-related protein 6 OS=Homo sapiens GN=OSBPL6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25636 BP_3 41.00 5.06 682 546682766 ERL92655.1 361 6.1e-32 hypothetical protein D910_09968 [Dendroctonus ponderosae] -- -- -- -- -- K00020 E1.1.1.31, mmsB 3-hydroxyisobutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00020 Q9L7S0 244 9.3e-20 3-sulfolactaldehyde reductase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=yihU PE=3 SV=1 PF03720//PF03446//PF02826//PF01210//PF02737 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0046168//GO:0006633//GO:0006098//GO:0018874//GO:0006631//GO:0006552//GO:0006574//GO:0006550//GO:0006568//GO:0019521//GO:0006554//GO:0055114 glycerol-3-phosphate catabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//fatty acid metabolic process//leucine catabolic process//valine catabolic process//isoleucine catabolic process//tryptophan metabolic process//D-gluconate metabolic process//lysine catabolic process//oxidation-reduction process GO:0016491//GO:0051287//GO:0016616//GO:0003857//GO:0004616 oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG0409 Predicted dehydrogenase Cluster-8309.25638 BP_3 125.35 2.76 2481 332373480 AEE61881.1 672 1.9e-67 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00798 MMAB, pduO cob(I)alamin adenosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00798 Q96EY8 328 6.1e-29 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial OS=Homo sapiens GN=MMAB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25645 BP_3 1.00 1.10 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25646 BP_3 2.00 0.57 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25647 BP_3 249.40 3.82 3439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00651//PF04573 BTB/POZ domain//Signal peptidase subunit GO:0006465 signal peptide processing GO:0005515//GO:0008233 protein binding//peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-8309.2565 BP_3 75.87 1.11 3591 91090914 XP_974006.1 2359 6.7e-263 PREDICTED: NCK-interacting protein with SH3 domain [Tribolium castaneum]>gi|270013220|gb|EFA09668.1| hypothetical protein TcasGA2_TC011794 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESJ4 877 1.9e-92 NCK-interacting protein with SH3 domain OS=Mus musculus GN=Nckipsd PE=2 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover Cluster-8309.25650 BP_3 24.86 0.37 3500 642912878 XP_971323.2 657 1.5e-65 PREDICTED: EP300-interacting inhibitor of differentiation 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXX6 190 8.7e-13 Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens GN=NSMCE4A PE=1 SV=2 PF00790//PF01405 VHS domain//Photosystem II reaction centre T protein GO:0006886//GO:0015979 intracellular protein transport//photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane KOG2866 Uncharacterized conserved protein Cluster-8309.25651 BP_3 465.21 5.54 4336 642919915 XP_008192123.1 1850 8.5e-204 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9K8 222 2.1e-16 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0507 CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain Cluster-8309.25653 BP_3 3.00 0.76 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25656 BP_3 169.80 1.63 5306 546678750 ERL89302.1 1238 9.6e-133 hypothetical protein D910_06674 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05656//PF12106 Protein of unknown function (DUF805)//Colicin C terminal ribonuclease domain GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.25657 BP_3 200.64 5.42 2077 546676934 ERL87858.1 1197 2.1e-128 hypothetical protein D910_05246 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26422 380 4.8e-35 Limulus clotting factor C OS=Carcinoscorpius rotundicauda PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.25658 BP_3 57.26 0.92 3289 478253154 ENN73525.1 1577 2.9e-172 hypothetical protein YQE_09776, partial [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 854 8.3e-90 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF06756//PF01370//PF01073 Male sterility protein//Chorion protein S19 C-terminal//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008209//GO:0006694//GO:0055114//GO:0008207//GO:0008210//GO:0007275 androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//estrogen metabolic process//multicellular organismal development GO:0080019//GO:0016616//GO:0003824//GO:0050662//GO:0003854 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0042600 chorion KOG1221 Acyl-CoA reductase Cluster-8309.2566 BP_3 50.67 0.70 3757 91090914 XP_974006.1 2354 2.7e-262 PREDICTED: NCK-interacting protein with SH3 domain [Tribolium castaneum]>gi|270013220|gb|EFA09668.1| hypothetical protein TcasGA2_TC011794 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESJ4 877 2.0e-92 NCK-interacting protein with SH3 domain OS=Mus musculus GN=Nckipsd PE=2 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover Cluster-8309.25662 BP_3 564.24 5.33 5395 642939323 XP_969087.2 928 8.7e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.637e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF03876//PF01588 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Putative tRNA binding domain GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0000049//GO:0003899 tRNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG2241 tRNA-binding protein Cluster-8309.25663 BP_3 279.07 9.95 1643 642937136 XP_008198708.1 276 1.1e-21 PREDICTED: arginine/serine-rich protein PNISR [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04441 Poxvirus early transcription factor (VETF), large subunit GO:0045893 positive regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.25664 BP_3 29.48 1.03 1673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25667 BP_3 75.81 1.02 3869 642922614 XP_008193249.1 1384 8.2e-150 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25668 BP_3 578.58 21.40 1595 642913239 XP_008201452.1 1470 3.6e-160 PREDICTED: WD repeat-containing protein 61 [Tribolium castaneum]>gi|270001971|gb|EEZ98418.1| hypothetical protein TcasGA2_TC000886 [Tribolium castaneum] 780072616 XM_791333.4 58 4.09556e-19 PREDICTED: Strongylocentrotus purpuratus WD repeat-containing protein 61-like (LOC591782), mRNA K12602 WDR61, REC14, SKI8 WD repeat-containing protein 61 http://www.genome.jp/dbget-bin/www_bget?ko:K12602 Q6P5M2 1052 4.4e-113 WD repeat-containing protein 61 OS=Danio rerio GN=wdr61 PE=2 SV=1 PF02897//PF04053//PF00400 Prolyl oligopeptidase, N-terminal beta-propeller domain//Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0070008//GO:0004252//GO:0005515//GO:0005198 serine-type exopeptidase activity//serine-type endopeptidase activity//protein binding//structural molecule activity GO:0030117 membrane coat KOG4155 FOG: WD40 repeat Cluster-8309.25669 BP_3 2.00 1.78 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25670 BP_3 71.44 1.63 2405 91076548 XP_966358.1 499 2.1e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.6e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF00010//PF05093 Helix-loop-helix DNA-binding domain//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0016226 iron-sulfur cluster assembly GO:0046983//GO:0051536 protein dimerization activity//iron-sulfur cluster binding GO:0005737 cytoplasm KOG4020 Protein DRE2, required for cell viability Cluster-8309.25676 BP_3 80.25 0.72 5644 642927663 XP_008195354.1 1282 8.1e-138 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 Q9Y2K5 394 3.1e-36 R3H domain-containing protein 2 OS=Homo sapiens GN=R3HDM2 PE=1 SV=3 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.25677 BP_3 20.00 0.41 2649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25678 BP_3 141.00 8.34 1107 766938885 XP_011501969.1 577 8.9e-57 PREDICTED: troponin T, skeletal muscle isoform X1 [Ceratosolen solmsi marchali] -- -- -- -- -- K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 Q9XZ71 491 3.4e-48 Troponin T OS=Periplaneta americana GN=TNT PE=2 SV=1 PF00992 Troponin -- -- -- -- GO:0005861 troponin complex KOG3634 Troponin Cluster-8309.25679 BP_3 9.00 0.34 1568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25680 BP_3 8.21 1.59 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25685 BP_3 144.13 0.90 8050 546671878 ERL83997.1 3669 0.0e+00 hypothetical protein D910_01313 [Dendroctonus ponderosae]>gi|546679661|gb|ERL90088.1| hypothetical protein D910_07442 [Dendroctonus ponderosae] -- -- -- -- -- K17935 SNX29 sorting nexin-29 http://www.genome.jp/dbget-bin/www_bget?ko:K17935 Q9VKB9 1409 8.9e-154 Rab3 GTPase-activating protein regulatory subunit OS=Drosophila melanogaster GN=rab3-GAP PE=1 SV=2 PF00787//PF04977//PF00957 PX domain//Septum formation initiator//Synaptobrevin GO:0007049//GO:0016192 cell cycle//vesicle-mediated transport GO:0035091 phosphatidylinositol binding GO:0016021 integral component of membrane KOG2727 Rab3 GTPase-activating protein, non-catalytic subunit Cluster-8309.25686 BP_3 135.85 0.93 7305 642929299 XP_008195778.1 5065 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 3578 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF08040//PF00647//PF00223//PF10152 MNLL subunit//Elongation factor 1 gamma, conserved domain//Photosystem I psaA/psaB protein//Predicted coiled-coil domain-containing protein (DUF2360) GO:0006414//GO:0015979//GO:0006448//GO:0006118 translational elongation//photosynthesis//regulation of translational elongation//obsolete electron transport GO:0003954//GO:0003746 NADH dehydrogenase activity//translation elongation factor activity GO:0016021//GO:0009522//GO:0005840//GO:0071203//GO:0009579//GO:0005739 integral component of membrane//photosystem I//ribosome//WASH complex//thylakoid//mitochondrion KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.25688 BP_3 280.30 4.15 3547 91094433 XP_969675.1 2027 2.1e-224 PREDICTED: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X2 [Tribolium castaneum] 752875257 XM_011256672.1 68 2.54398e-24 PREDICTED: Camponotus floridanus alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC105250520), transcript variant X5, mRNA K00736 MGAT2 alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00736 Q921V5 959 6.0e-102 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat2 PE=2 SV=1 PF00437//PF06414//PF02367//PF01121//PF05060 Type II/IV secretion system protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Dephospho-CoA kinase//N-acetylglucosaminyltransferase II (MGAT2) GO:0015937//GO:0002949//GO:0006810//GO:0009312//GO:0015940 coenzyme A biosynthetic process//tRNA threonylcarbamoyladenosine modification//transport//oligosaccharide biosynthetic process//pantothenate biosynthetic process GO:0004140//GO:0016301//GO:0008455//GO:0005524 dephospho-CoA kinase activity//kinase activity//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity//ATP binding GO:0005795//GO:0016021 Golgi stack//integral component of membrane KOG2791 N-acetylglucosaminyltransferase Cluster-8309.25690 BP_3 12.11 0.60 1263 478250090 ENN70596.1 654 1.2e-65 hypothetical protein YQE_12771, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25691 BP_3 774.19 11.16 3634 642930006 XP_008196062.1 305 1.0e-24 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 1.1e-18 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25692 BP_3 9.00 5.46 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25693 BP_3 8.98 7.12 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF00020//PF06784 Zinc-finger associated domain (zf-AD)//TNFR/NGFR cysteine-rich region//Uncharacterised protein family (UPF0240) GO:0032981 mitochondrial respiratory chain complex I assembly GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25696 BP_3 10.00 8.15 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25697 BP_3 5.00 1.76 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25699 BP_3 34.00 2.06 1089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25701 BP_3 12.00 1.15 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25703 BP_3 420.27 2.43 8639 642913355 XP_008195386.1 6061 0.0e+00 PREDICTED: protein polybromo-1 [Tribolium castaneum] -- -- -- -- -- K11757 PBRM1, PB1 protein polybromo-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11757 Q86U86 1886 4.7e-209 Protein polybromo-1 OS=Homo sapiens GN=PBRM1 PE=1 SV=1 PF07728//PF10505//PF07726//PF01580//PF01426//PF00493//PF00439 AAA domain (dynein-related subfamily)//NMDA receptor-regulated gene protein 2 C-terminus//ATPase family associated with various cellular activities (AAA)//FtsK/SpoIIIE family//BAH domain//MCM2/3/5 family//Bromodomain GO:0006260 DNA replication GO:0005515//GO:0003677//GO:0005524//GO:0003682//GO:0016887//GO:0000166 protein binding//DNA binding//ATP binding//chromatin binding//ATPase activity//nucleotide binding GO:0000785//GO:0008023 chromatin//transcription elongation factor complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.25704 BP_3 1.00 1.08 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25706 BP_3 30.82 0.84 2052 642915551 XP_008190663.1 1004 5.1e-106 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 70 1.13014e-25 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 353 6.4e-32 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.25710 BP_3 465.01 32.80 975 499140776 AGL76355.1 265 1.2e-20 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 241 3.0e-19 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05529//PF05531//PF03998 B-cell receptor-associated protein 31-like//Nucleopolyhedrovirus P10 protein//Utp11 protein GO:0006364//GO:0006886 rRNA processing//intracellular protein transport -- -- GO:0019028//GO:0016021//GO:0005783//GO:0032040 viral capsid//integral component of membrane//endoplasmic reticulum//small-subunit processome -- -- Cluster-8309.25711 BP_3 98.75 3.11 1824 642917000 XP_008199589.1 600 3.2e-59 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 238 1.2e-18 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.25712 BP_3 41.48 0.32 6561 642921466 XP_008192880.1 4105 0.0e+00 PREDICTED: transient receptor potential-gamma protein [Tribolium castaneum] 194884299 XM_001976197.1 386 0 Drosophila erecta GG20120 (Dere\GG20120), mRNA K05328 TRPCN transient receptor potential cation channel subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05328 Q9VJJ7 3423 0.0e+00 Transient receptor potential-gamma protein OS=Drosophila melanogaster GN=Trpgamma PE=1 SV=2 PF04692//PF09726//PF13606//PF00520 Platelet-derived growth factor, N terminal region//Transmembrane protein//Ankyrin repeat//Ion transport protein GO:0006811//GO:0008283//GO:0055085//GO:0040007//GO:0007165 ion transport//cell proliferation//transmembrane transport//growth//signal transduction GO:0005216//GO:0005515//GO:0008083 ion channel activity//protein binding//growth factor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3609 Receptor-activated Ca2+-permeable cation channels (STRPC family) Cluster-8309.25713 BP_3 1.00 0.36 423 642922420 XP_008193148.1 163 3.4e-09 PREDICTED: protein lifeguard 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LZ71 124 4.7e-06 Protein lifeguard 2 OS=Bos taurus GN=FAIM2 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.25715 BP_3 313.54 20.25 1038 642919467 XP_008191881.1 746 2.1e-76 PREDICTED: polyprenol reductase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12345 SRD5A3 3-oxo-5-alpha-steroid 4-dehydrogenase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12345 Q9VLP9 473 3.9e-46 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG1640 Predicted steroid reductase Cluster-8309.25716 BP_3 382.20 6.19 3267 189238741 XP_972079.2 3168 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927110|ref|XP_008195141.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927112|ref|XP_008195142.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927115|ref|XP_008195143.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum] 699256288 XM_009863644.1 39 3.09336e-08 PREDICTED: Ciona intestinalis ubiquitin carboxyl-terminal hydrolase 20-like (LOC100184024), mRNA K11848 USP20_33 ubiquitin carboxyl-terminal hydrolase 20/33 http://www.genome.jp/dbget-bin/www_bget?ko:K11848 A0JM59 1233 9.3e-134 Ubiquitin carboxyl-terminal hydrolase 20 OS=Xenopus tropicalis GN=usp20 PE=2 SV=1 PF00443//PF06337//PF17001//PF02148 Ubiquitin carboxyl-terminal hydrolase//DUSP domain//Type III secretion basal body protein I, YscI, HrpB, PscI//Zn-finger in ubiquitin-hydrolases and other protein GO:0006508//GO:0016579//GO:0009306 proteolysis//protein deubiquitination//protein secretion GO:0004843//GO:0008270//GO:0036459 ubiquitin-specific protease activity//zinc ion binding//ubiquitinyl hydrolase activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.25719 BP_3 109.60 1.75 3306 478259275 ENN79177.1 371 2.1e-32 hypothetical protein YQE_04361, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25720 BP_3 434.14 10.93 2206 189238996 XP_974023.2 1856 8.7e-205 PREDICTED: E3 SUMO-protein ligase PIAS2 [Tribolium castaneum]>gi|270010268|gb|EFA06716.1| hypothetical protein TcasGA2_TC009647 [Tribolium castaneum] -- -- -- -- -- K04706 PIAS1 E3 SUMO-protein ligase PIAS1 http://www.genome.jp/dbget-bin/www_bget?ko:K04706 O70260 1111 8.8e-120 E3 SUMO-protein ligase PIAS3 OS=Rattus norvegicus GN=Pias3 PE=1 SV=2 PF13639//PF11789//PF00097//PF02891 Ring finger domain//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger -- -- GO:0008270//GO:0005488//GO:0005515//GO:0046872 zinc ion binding//binding//protein binding//metal ion binding -- -- KOG2169 Zn-finger transcription factor Cluster-8309.25721 BP_3 80.54 2.48 1860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25722 BP_3 83.00 7.76 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25724 BP_3 29.00 2.11 954 642912272 XP_008200632.1 309 9.2e-26 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25725 BP_3 11.00 1.78 589 642912278 XP_967486.2 173 3.3e-10 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25728 BP_3 14.15 0.36 2204 642912272 XP_008200632.1 843 2.5e-87 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 298 1.6e-25 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF05392//PF00089 Cytochrome C oxidase chain VIIB//Trypsin GO:0015992//GO:0006508//GO:0006123 proton transport//proteolysis//mitochondrial electron transport, cytochrome c to oxygen GO:0004252//GO:0004129 serine-type endopeptidase activity//cytochrome-c oxidase activity GO:0005746//GO:0045277 mitochondrial respiratory chain//respiratory chain complex IV -- -- Cluster-8309.25731 BP_3 26.92 1.17 1402 642912272 XP_008200632.1 540 2.2e-52 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66TN7 173 3.3e-11 Ovochymase-2 OS=Rhinella arenarum GN=OVCH2 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.25733 BP_3 77.00 3.40 1383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25736 BP_3 52.82 1.79 1710 751222454 XP_011164462.1 998 2.1e-105 PREDICTED: zinc finger CCCH-type with G patch domain-containing protein [Solenopsis invicta] -- -- -- -- -- -- -- -- -- Q17CQ8 981 8.1e-105 Zinc finger CCCH-type with G patch domain-containing protein OS=Aedes aegypti GN=AAEL004458 PE=3 SV=1 PF00642//PF01585 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//G-patch domain -- -- GO:0003676//GO:0046872 nucleic acid binding//metal ion binding -- -- KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.25737 BP_3 1742.43 12.40 7067 91085635 XP_970327.1 2265 1.0e-251 PREDICTED: uncharacterized protein LOC658883 [Tribolium castaneum]>gi|270010087|gb|EFA06535.1| hypothetical protein TcasGA2_TC009439 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00705 Proliferating cell nuclear antigen, N-terminal domain GO:0006275 regulation of DNA replication GO:0003677 DNA binding -- -- -- -- Cluster-8309.25738 BP_3 65.52 0.46 7112 91085635 XP_970327.1 2265 1.1e-251 PREDICTED: uncharacterized protein LOC658883 [Tribolium castaneum]>gi|270010087|gb|EFA06535.1| hypothetical protein TcasGA2_TC009439 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00705 Proliferating cell nuclear antigen, N-terminal domain GO:0006275 regulation of DNA replication GO:0003677 DNA binding -- -- -- -- Cluster-8309.25741 BP_3 500.99 41.19 878 642933127 XP_008197269.1 697 8.6e-71 PREDICTED: charged multivesicular body protein 2b [Tribolium castaneum]>gi|270011429|gb|EFA07877.1| hypothetical protein TcasGA2_TC005451 [Tribolium castaneum] -- -- -- -- -- K12192 CHMP2B charged multivesicular body protein 2B http://www.genome.jp/dbget-bin/www_bget?ko:K12192 Q66IV6 388 2.4e-36 Charged multivesicular body protein 2b-B OS=Xenopus laevis GN=chmp2b-b PE=2 SV=1 PF03357 Snf7 GO:0007034 vacuolar transport -- -- -- -- KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.25742 BP_3 350.31 2.61 6771 820864069 XP_012348652.1 1708 3.9e-187 PREDICTED: LOW QUALITY PROTEIN: mucin-5AC [Apis florea] -- -- -- -- -- -- -- -- -- Q6W2J9 449 1.6e-42 BCL-6 corepressor OS=Homo sapiens GN=BCOR PE=1 SV=1 PF13606//PF00023//PF01361 Ankyrin repeat//Ankyrin repeat//Tautomerase enzyme GO:0006725 cellular aromatic compound metabolic process GO:0016853//GO:0005515 isomerase activity//protein binding -- -- -- -- Cluster-8309.25743 BP_3 285.53 3.07 4777 91086891 XP_970454.1 569 3.3e-55 PREDICTED: putative gamma-glutamylcyclotransferase CG2811 isoform X1 [Tribolium castaneum]>gi|270010478|gb|EFA06926.1| hypothetical protein TcasGA2_TC009875 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y2 357 5.1e-32 Putative gamma-glutamylcyclotransferase CG2811 OS=Drosophila melanogaster GN=CG2811 PE=2 SV=2 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- KOG4450 Uncharacterized conserved protein Cluster-8309.25744 BP_3 13479.73 333.14 2242 642914102 XP_008201543.1 1509 1.5e-164 PREDICTED: ras-interacting protein RIP3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379//PF06371//PF00916 Insect cuticle protein//Diaphanous GTPase-binding Domain//Sulfate permease family GO:0008272//GO:0030036 sulfate transport//actin cytoskeleton organization GO:0015116//GO:0042302//GO:0017048//GO:0003779 sulfate transmembrane transporter activity//structural constituent of cuticle//Rho GTPase binding//actin binding GO:0016021 integral component of membrane -- -- Cluster-8309.25747 BP_3 94.63 2.08 2486 642919661 XP_008192012.1 202 6.1e-13 PREDICTED: kinesin light chain isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25748 BP_3 459.98 16.52 1634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01446 Replication protein GO:0006260 DNA replication GO:0003677 DNA binding GO:0005727 extrachromosomal circular DNA -- -- Cluster-8309.25749 BP_3 254.76 9.18 1629 91076220 XP_972698.1 1772 3.5e-195 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum]>gi|270014737|gb|EFA11185.1| hypothetical protein TcasGA2_TC004793 [Tribolium castaneum] 462373375 APGK01024771.1 206 2.23321e-101 Dendroctonus ponderosae Seq01024781, whole genome shotgun sequence K14353 SLCO3A solute carrier organic anion transporter family, member 3A http://www.genome.jp/dbget-bin/www_bget?ko:K14353 Q99N01 455 7.6e-44 Solute carrier organic anion transporter family member 4A1 OS=Rattus norvegicus GN=Slco4a1 PE=2 SV=1 PF07690//PF03137 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3626 Organic anion transporter Cluster-8309.25753 BP_3 90.00 7.93 839 478250393 ENN70888.1 799 1.2e-82 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] 532094238 XM_005332740.1 34 4.64138e-06 PREDICTED: Spermophilus tridecemlineatus fatty acid synthase (Fasn), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 682 1.9e-70 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.25754 BP_3 43.92 4.74 738 546672885 ERL84608.1 714 7.7e-73 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 617 5.6e-63 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107//PF00106 Zinc-binding dehydrogenase//short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.25756 BP_3 203.71 7.25 1646 332375332 AEE62807.1 1414 1.2e-153 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 464 6.9e-45 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00098//PF00852 Zinc knuckle//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008417//GO:0003676//GO:0008270 fucosyltransferase activity//nucleic acid binding//zinc ion binding GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.25757 BP_3 978.06 53.49 1173 459485591 AGG68958.1 1339 4.1e-145 prohibitin-1 [Leptinotarsa decemlineata] 459485590 JX275964.1 294 1.92156e-150 Leptinotarsa decemlineata prohibitin-1 mRNA, complete cds K17080 PHB1 prohibitin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17080 P24156 1162 5.7e-126 Protein l(2)37Cc OS=Drosophila melanogaster GN=l(2)37Cc PE=2 SV=2 PF03242 Late embryogenesis abundant protein GO:0006950 response to stress -- -- -- -- KOG3083 Prohibitin Cluster-8309.25758 BP_3 2.00 7.85 271 91094083 XP_970629.1 248 3.1e-19 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270016176|gb|EFA12624.1| hypothetical protein TcasGA2_TC010257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 200 4.6e-15 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF02882//PF00106//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0055114//GO:0009396//GO:0046487//GO:0008152 oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//metabolic process GO:0000166//GO:0016491//GO:0004488//GO:0003824//GO:0050662 nucleotide binding//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.25760 BP_3 365.85 6.16 3154 91094507 XP_971663.1 1499 3.1e-163 PREDICTED: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [Tribolium castaneum]>gi|270000751|gb|EEZ97198.1| hypothetical protein TcasGA2_TC004386 [Tribolium castaneum] -- -- -- -- -- K00166 BCKDHA, bkdA1 2-oxoisovalerate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00166 Q8HXY4 1341 2.7e-146 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Macaca fascicularis GN=BCKDHA PE=2 SV=1 PF13292//PF01553//PF02775//PF00676 1-deoxy-D-xylulose-5-phosphate synthase//Acyltransferase//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Dehydrogenase E1 component GO:0008152//GO:0016114//GO:0006694 metabolic process//terpenoid biosynthetic process//steroid biosynthetic process GO:0016624//GO:0003824//GO:0016746//GO:0030976//GO:0008661 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity//transferase activity, transferring acyl groups//thiamine pyrophosphate binding//1-deoxy-D-xylulose-5-phosphate synthase activity -- -- KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.25763 BP_3 405.18 4.72 4431 642923468 XP_008193757.1 632 1.5e-62 PREDICTED: glia maturation factor beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49858 447 1.7e-42 Protein cornichon OS=Drosophila melanogaster GN=cni PE=1 SV=1 PF03311//PF00241 Cornichon protein//Cofilin/tropomyosin-type actin-binding protein GO:0035556 intracellular signal transduction GO:0003779 actin binding GO:0016020//GO:0005622 membrane//intracellular KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.25764 BP_3 7.18 0.41 1129 91087501 XP_968536.1 365 3.5e-32 PREDICTED: DNA replication complex GINS protein PSF3 [Tribolium castaneum]>gi|270010665|gb|EFA07113.1| hypothetical protein TcasGA2_TC010104 [Tribolium castaneum] -- -- -- -- -- K10734 GINS3 GINS complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10734 Q08E12 144 6.1e-08 DNA replication complex GINS protein PSF3 OS=Bos taurus GN=GINS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25765 BP_3 283.81 3.04 4796 270004497 EFA00945.1 1275 4.5e-137 hypothetical protein TcasGA2_TC003854 [Tribolium castaneum] -- -- -- -- -- K14416 HBS1 elongation factor 1 alpha-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K14416 Q2KHZ2 863 1.1e-90 HBS1-like protein OS=Bos taurus GN=HBS1L PE=2 SV=1 PF08477//PF01926//PF05773 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//RWD domain GO:0007264 small GTPase mediated signal transduction GO:0005515//GO:0005525 protein binding//GTP binding -- -- KOG0458 Elongation factor 1 alpha Cluster-8309.25766 BP_3 12.34 0.39 1804 270014935 EFA11383.1 361 1.6e-31 hypothetical protein TcasGA2_TC011543 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D136 264 1.2e-21 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Mus musculus GN=Ogfod3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25769 BP_3 41.08 1.37 1739 478258496 ENN78571.1 1784 1.5e-196 hypothetical protein YQE_04939, partial [Dendroctonus ponderosae]>gi|546677392|gb|ERL88238.1| hypothetical protein D910_05626 [Dendroctonus ponderosae] 768436038 XM_011561181.1 53 2.69242e-16 PREDICTED: Plutella xylostella PRKCA-binding protein-like (LOC105389970), mRNA -- -- -- -- Q5REH1 1186 1.4e-128 PRKCA-binding protein OS=Pongo abelii GN=PICK1 PE=2 SV=1 PF00595//PF06456//PF13180 PDZ domain (Also known as DHR or GLGF)//Arfaptin-like domain//PDZ domain -- -- GO:0019904//GO:0005515 protein domain specific binding//protein binding -- -- KOG3651 Protein kinase C, alpha binding protein Cluster-8309.25771 BP_3 435.00 10.99 2200 642936940 XP_008198620.1 198 1.6e-12 PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum]>gi|642936942|ref|XP_008198621.1| PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25773 BP_3 51.64 2.93 1140 546677187 ERL88072.1 235 4.2e-17 hypothetical protein D910_05461, partial [Dendroctonus ponderosae] 642936943 XM_008200400.1 88 6.11184e-36 PREDICTED: Tribolium castaneum angiomotin-like protein 1 (LOC654850), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25774 BP_3 1266.19 21.61 3116 642936944 XP_008198622.1 2562 1.7e-286 PREDICTED: angiomotin-like 2a isoform X2 [Tribolium castaneum] -- -- -- -- -- K16819 AMOT angiomotin http://www.genome.jp/dbget-bin/www_bget?ko:K16819 Q4VCS5 521 3.2e-51 Angiomotin OS=Homo sapiens GN=AMOT PE=1 SV=1 PF05531 Nucleopolyhedrovirus P10 protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.25775 BP_3 19.65 0.68 1694 478253593 ENN73901.1 295 6.8e-24 hypothetical protein YQE_09500, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25776 BP_3 124.22 1.65 3918 642936946 XP_008198623.1 2270 1.5e-252 PREDICTED: angiomotin-like protein 1 isoform X3 [Tribolium castaneum] 642936945 XM_008200401.1 387 0 PREDICTED: Tribolium castaneum angiomotin-like protein 1 (LOC654850), transcript variant X4, mRNA K16819 AMOT angiomotin http://www.genome.jp/dbget-bin/www_bget?ko:K16819 Q4VCS5 521 4.0e-51 Angiomotin OS=Homo sapiens GN=AMOT PE=1 SV=1 PF05531 Nucleopolyhedrovirus P10 protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.25777 BP_3 8.92 0.36 1499 270012966 EFA09414.1 151 3.0e-07 hypothetical protein TcasGA2_TC005216 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25778 BP_3 209.51 8.77 1443 642919030 XP_008191704.1 876 2.5e-91 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 194893660 XM_001977880.1 36 6.2737e-07 Drosophila erecta GG19306 (Dere\GG19306), mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 -- -- -- -- PF10458//PF12920 Valyl tRNA synthetase tRNA binding arm//TcdA/TcdB pore forming domain GO:0009099//GO:0009098//GO:0006438//GO:0009405//GO:0009097 valine biosynthetic process//leucine biosynthetic process//valyl-tRNA aminoacylation//pathogenesis//isoleucine biosynthetic process GO:0000166//GO:0004832//GO:0005524 nucleotide binding//valine-tRNA ligase activity//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.25779 BP_3 25.00 0.35 3741 642934754 XP_967096.2 1811 2.4e-199 PREDICTED: sorting nexin-30 [Tribolium castaneum] -- -- -- -- -- K17921 SNX7_30 sorting nexin-7/30 http://www.genome.jp/dbget-bin/www_bget?ko:K17921 Q5VWJ9 561 8.9e-56 Sorting nexin-30 OS=Homo sapiens GN=SNX30 PE=1 SV=1 PF02985//PF00787//PF03114 HEAT repeat//PX domain//BAR domain -- -- GO:0035091//GO:0005515 phosphatidylinositol binding//protein binding GO:0005737 cytoplasm KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.25780 BP_3 12.78 0.33 2180 134131322 BAF49604.1 1050 2.5e-111 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 531 1.6e-52 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF00089 Glycosyl hydrolases family 18//Trypsin GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004252//GO:0004553 serine-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.25782 BP_3 53.08 5.09 794 91093363 XP_969584.1 622 3.9e-62 PREDICTED: proliferation-associated protein 2G4 [Tribolium castaneum]>gi|270015297|gb|EFA11745.1| hypothetical protein TcasGA2_TC004235 [Tribolium castaneum] 112420264 BT027081.1 59 5.54934e-20 Gasterosteus aculeatus clone CFW165-G07 mRNA sequence -- -- -- -- P50580 412 3.6e-39 Proliferation-associated protein 2G4 OS=Mus musculus GN=Pa2g4 PE=1 SV=3 PF01781 Ribosomal L38e protein family GO:0042254//GO:0006412//GO:0009987 ribosome biogenesis//translation//cellular process GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2776 Metallopeptidase Cluster-8309.25784 BP_3 854.80 8.40 5198 642936907 XP_008194437.1 1988 1.0e-219 PREDICTED: fasciclin-1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 1347 8.9e-147 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 PF15427//PF04433 S100P-binding protein//SWIRM domain -- -- GO:0048306//GO:0005515 calcium-dependent protein binding//protein binding -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.25788 BP_3 10.58 0.31 1948 478258504 ENN78579.1 891 6.1e-93 hypothetical protein YQE_04947, partial [Dendroctonus ponderosae]>gi|546681353|gb|ERL91463.1| hypothetical protein D910_08793 [Dendroctonus ponderosae] -- -- -- -- -- K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 Q6NYL5 629 6.0e-64 Alanine aminotransferase 2-like OS=Danio rerio GN=gpt2l PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0258 Alanine aminotransferase Cluster-8309.25791 BP_3 18.01 0.50 2012 642935785 XP_008198173.1 306 4.3e-25 PREDICTED: uncharacterized protein LOC655305 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25795 BP_3 169.43 3.34 2738 646702398 KDR11610.1 798 5.2e-82 GTP-binding protein Rheb-like protein [Zootermopsis nevadensis] 556946329 XM_005986343.1 39 2.5869e-08 PREDICTED: Latimeria chalumnae GTP-binding protein Rheb-like (LOC102353752), mRNA K07208 RHEB Ras homolog enriched in brain http://www.genome.jp/dbget-bin/www_bget?ko:K07208 Q9VND8 698 8.4e-72 GTP-binding protein Rheb homolog OS=Drosophila melanogaster GN=Rheb PE=2 SV=1 PF01926//PF01637//PF08477//PF03193//PF00071//PF00025 50S ribosome-binding GTPase//Archaeal ATPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005525//GO:0005524 GTPase activity//GTP binding//ATP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.25796 BP_3 52.50 0.89 3132 236468408 NP_001153625.1 1219 9.1e-131 spaetzle 3 [Tribolium castaneum] 817194790 XM_012417488.1 155 9.72412e-73 PREDICTED: Orussus abietinus uncharacterized LOC105695690 (LOC105695690), mRNA -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.25797 BP_3 77.00 1.70 2479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25798 BP_3 357.47 5.21 3597 332374232 AEE62257.1 402 5.7e-36 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VBV3 253 4.4e-20 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25799 BP_3 673.00 23.74 1658 478249792 ENN70299.1 375 3.5e-33 hypothetical protein YQE_12810, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08918 PhoQ Sensor GO:0018106//GO:0016310//GO:0000160 peptidyl-histidine phosphorylation//phosphorylation//phosphorelay signal transduction system GO:0046872//GO:0004673//GO:0005524 metal ion binding//protein histidine kinase activity//ATP binding GO:0016020//GO:0009365 membrane//protein histidine kinase complex -- -- Cluster-8309.2580 BP_3 4.00 0.54 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25800 BP_3 34.00 1.44 1429 758375335 AJO70008.1 1904 1.5e-210 sarco/endoplasmic reticulum calcium-ATPase isoform 3 [Cherax destructor] 768415454 XM_011549976.1 557 0 PREDICTED: Plutella xylostella calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC105380420), transcript variant X5, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 1714 6.8e-190 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.25801 BP_3 80.61 1.34 3183 546684480 ERL94119.1 710 9.7e-72 hypothetical protein D910_11401 [Dendroctonus ponderosae] -- -- -- -- -- K18407 TDRD5 tudor domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18407 Q4R3G4 152 2.0e-08 RING finger protein 17 OS=Macaca fascicularis GN=RNF17 PE=2 SV=2 PF15151 Response gene to complement 32 protein family GO:0051726 regulation of cell cycle -- -- -- -- -- -- Cluster-8309.25805 BP_3 6.68 0.77 709 260815187 XP_002602355.1 228 1.7e-16 hypothetical protein BRAFLDRAFT_234331 [Branchiostoma floridae]>gi|229287664|gb|EEN58367.1| hypothetical protein BRAFLDRAFT_234331, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- O54963 196 3.5e-14 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25806 BP_3 2901.13 107.29 1595 642922477 XP_973426.2 500 1.1e-47 PREDICTED: uncharacterized protein LOC662220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76879 176 1.7e-11 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25808 BP_3 552.96 12.72 2387 642928048 XP_008200135.1 818 2.2e-84 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 2.2e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF04508//PF00038//PF04986//PF09392//PF10473//PF01008 Viral A-type inclusion protein repeat//Intermediate filament protein//Putative transposase//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Initiation factor 2 subunit family GO:0006313//GO:0044237//GO:0009405//GO:0016032//GO:0015031 transposition, DNA-mediated//cellular metabolic process//pathogenesis//viral process//protein transport GO:0005198//GO:0045502//GO:0008134//GO:0003677//GO:0004803//GO:0042803 structural molecule activity//dynein binding//transcription factor binding//DNA binding//transposase activity//protein homodimerization activity GO:0005882//GO:0005667//GO:0030286 intermediate filament//transcription factor complex//dynein complex -- -- Cluster-8309.25811 BP_3 625.00 39.57 1053 91077606 XP_973520.1 636 1.2e-63 PREDICTED: LDLR chaperone boca [Tribolium castaneum]>gi|270001559|gb|EEZ98006.1| hypothetical protein TcasGA2_TC000405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T9B6 585 4.1e-59 LDLR chaperone boca OS=Drosophila melanogaster GN=boca PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4357 Uncharacterized conserved protein (involved in mesoderm differentiation in humans) Cluster-8309.25812 BP_3 743.38 9.55 4043 642915003 XP_008190478.1 1917 1.4e-211 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915005|ref|XP_008190479.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915007|ref|XP_008190480.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|270002347|gb|EEZ98794.1| hypothetical protein TcasGA2_TC001358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 985 6.6e-105 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF07147//PF00501 Mitochondrial 28S ribosomal protein S30 (PDCD9)//AMP-binding enzyme GO:0042254//GO:0006412//GO:0008152 ribosome biogenesis//translation//metabolic process GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005739//GO:0005840 mitochondrion//ribosome KOG1176 Acyl-CoA synthetase Cluster-8309.25814 BP_3 177.94 2.24 4113 642915003 XP_008190478.1 1917 1.4e-211 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915005|ref|XP_008190479.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915007|ref|XP_008190480.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|270002347|gb|EEZ98794.1| hypothetical protein TcasGA2_TC001358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 985 6.7e-105 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501//PF07147 AMP-binding enzyme//Mitochondrial 28S ribosomal protein S30 (PDCD9) GO:0008152//GO:0042254//GO:0006412 metabolic process//ribosome biogenesis//translation GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0005840//GO:0005739 ribosome//mitochondrion KOG1176 Acyl-CoA synthetase Cluster-8309.25815 BP_3 508.89 3.78 6780 642916006 XP_008190854.1 2795 0.0e+00 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96923 134 5.3e-06 Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum GN=gnrA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25817 BP_3 2250.00 96.38 1417 332372854 AEE61569.1 1719 4.3e-189 unknown [Dendroctonus ponderosae] 815766998 XM_012367995.1 243 5.23315e-122 PREDICTED: Linepithema humile obg-like ATPase 1 (LOC105672805), transcript variant X4, mRNA K06942 K06942 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06942 Q8SWU7 1511 2.3e-166 Obg-like ATPase 1 OS=Drosophila melanogaster GN=CG1354 PE=1 SV=1 PF02421//PF01926//PF08477 Ferrous iron transport protein B//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG1491 Predicted GTP-binding protein (ODN superfamily) Cluster-8309.2582 BP_3 2.00 1.03 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25820 BP_3 20.03 0.47 2333 642914581 XP_008190273.1 1779 7.8e-196 PREDICTED: uncharacterized protein LOC660922 isoform X1 [Tribolium castaneum] 642914580 XM_008192051.1 302 1.38575e-154 PREDICTED: Tribolium castaneum uncharacterized LOC660922 (LOC660922), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25826 BP_3 112.49 1.49 3940 642936940 XP_008198620.1 2491 3.6e-278 PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum]>gi|642936942|ref|XP_008198621.1| PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum] 642936943 XM_008200400.1 409 0 PREDICTED: Tribolium castaneum angiomotin-like protein 1 (LOC654850), transcript variant X3, mRNA K16819 AMOT angiomotin http://www.genome.jp/dbget-bin/www_bget?ko:K16819 Q4VCS5 521 4.1e-51 Angiomotin OS=Homo sapiens GN=AMOT PE=1 SV=1 PF05531 Nucleopolyhedrovirus P10 protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.25837 BP_3 7.84 0.55 985 91087165 XP_975370.1 471 1.5e-44 PREDICTED: protein max isoform X3 [Tribolium castaneum] -- -- -- -- -- K04453 MAX Max protein http://www.genome.jp/dbget-bin/www_bget?ko:K04453 P52162 242 2.3e-19 Protein max OS=Gallus gallus GN=MAX PE=3 SV=1 PF07716//PF00010//PF11095 Basic region leucine zipper//Helix-loop-helix DNA-binding domain//Gem-associated protein 7 (Gemin7) GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0046983//GO:0043565 transcription factor activity, sequence-specific DNA binding//protein dimerization activity//sequence-specific DNA binding GO:0032797//GO:0005667 SMN complex//transcription factor complex KOG2483 Upstream transcription factor 2/L-myc-2 protein Cluster-8309.25838 BP_3 14.10 0.31 2486 91076548 XP_966358.1 499 2.2e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.7e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF07716//PF05093 Basic region leucine zipper//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0016226//GO:0006355 iron-sulfur cluster assembly//regulation of transcription, DNA-templated GO:0051536//GO:0043565//GO:0003700 iron-sulfur cluster binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG4020 Protein DRE2, required for cell viability Cluster-8309.25841 BP_3 8.00 0.43 1198 546686406 ERL95679.1 603 9.3e-60 hypothetical protein D910_00109, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF01047 Transposase//MarR family GO:0006355//GO:0006313//GO:0015074 regulation of transcription, DNA-templated//transposition, DNA-mediated//DNA integration GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.25843 BP_3 11.00 0.38 1695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25844 BP_3 642.00 682.58 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25845 BP_3 284.04 3.37 4359 91091668 XP_971563.1 1101 6.1e-117 PREDICTED: docking protein 2 [Tribolium castaneum]>gi|270001055|gb|EEZ97502.1| hypothetical protein TcasGA2_TC011346 [Tribolium castaneum] -- -- -- -- -- K17808 ZIM17, DNLZ, Tim15 mitochondrial protein import protein ZIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17808 A1L1P7 281 3.0e-23 DNL-type zinc finger protein OS=Danio rerio GN=dnlz PE=2 SV=1 PF05180//PF02174 DNL zinc finger//PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0008270//GO:0005158 zinc ion binding//insulin receptor binding GO:0005899 insulin receptor complex KOG3277 Uncharacterized conserved protein Cluster-8309.25846 BP_3 7.00 0.39 1167 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25849 BP_3 131.00 13.93 745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03325 Herpesvirus polymerase accessory protein GO:0006260//GO:0019079 DNA replication//viral genome replication GO:0030337 DNA polymerase processivity factor activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.2585 BP_3 27.47 4.81 567 258588258 3F12 575 7.7e-57 Chain A, Germline V-Genes Sculpt The Binding Site Of A Family Of Antibodies Neutralizing Human Cytomegalovirus>gi|258588260|pdb|3F12|C Chain C, Germline V-Genes Sculpt The Binding Site Of A Family Of Antibodies Neutralizing Human Cytomegalovirus 49257006 BC073791.1 554 0 Homo sapiens immunoglobulin kappa constant, mRNA (cDNA clone IMAGE:6279986) -- -- -- -- P01834 482 1.9e-47 Ig kappa chain C region OS=Homo sapiens GN=IGKC PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25851 BP_3 2.00 0.38 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25852 BP_3 66.47 0.85 4053 642910771 XP_008193403.1 2110 5.7e-234 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.0e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00620//PF10297 RhoGAP domain//Minimal binding motif of Hap4 for binding to Hap2/3/5 GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.25855 BP_3 217.00 10.28 1309 189241734 XP_966970.2 661 1.9e-66 PREDICTED: ubiquinol-cytochrome-c reductase complex assembly factor 1 [Tribolium castaneum]>gi|270001140|gb|EEZ97587.1| hypothetical protein TcasGA2_TC011450 [Tribolium castaneum] -- -- -- -- -- K17662 CBP3, UQCC cytochrome b pre-mRNA-processing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17662 Q9W6I0 321 2.1e-28 Ubiquinol-cytochrome-c reductase complex assembly factor 1 OS=Xenopus laevis GN=uqcc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2873 Ubiquinol cytochrome c reductase assembly protein CBP3 Cluster-8309.25858 BP_3 546.00 14.70 2082 91084059 XP_967515.1 2369 2.7e-264 PREDICTED: nucleolar GTP-binding protein 2 [Tribolium castaneum]>gi|270008006|gb|EFA04454.1| hypothetical protein TcasGA2_TC014758 [Tribolium castaneum] -- -- -- -- -- K14537 NUG2, GNL2 nuclear GTP-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14537 Q99LH1 1447 9.0e-159 Nucleolar GTP-binding protein 2 OS=Mus musculus GN=Gnl2 PE=2 SV=2 PF01926//PF03193//PF02421//PF00025 50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ferrous iron transport protein B//ADP-ribosylation factor family GO:0015684 ferrous iron transport GO:0015093//GO:0005525//GO:0003924 ferrous iron transmembrane transporter activity//GTP binding//GTPase activity GO:0016021//GO:0005730 integral component of membrane//nucleolus KOG2423 Nucleolar GTPase Cluster-8309.2586 BP_3 9.00 1.24 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25860 BP_3 981.00 93.21 799 817086814 XP_012266154.1 332 1.6e-28 PREDICTED: protein transport protein Sec61 subunit beta [Athalia rosae] 762139005 XM_011454539.1 79 4.25746e-31 PREDICTED: Crassostrea gigas protein transport protein Sec61 subunit beta-like (LOC105346081), mRNA K09481 SEC61B, SBH2 protein transport protein SEC61 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K09481 P60467 284 2.5e-24 Protein transport protein Sec61 subunit beta OS=Canis familiaris GN=SEC61B PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3457 Sec61 protein translocation complex, beta subunit Cluster-8309.25861 BP_3 211.45 2.17 4991 189240067 XP_970199.2 2407 2.5e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.27315e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 5.0e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690//PF00083//PF05480 Major Facilitator Superfamily//Sugar (and other) transporter//Staphylococcus haemolytic protein GO:0009405//GO:0055085 pathogenesis//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.25865 BP_3 476.62 12.45 2137 91092436 XP_968632.1 1512 6.5e-165 PREDICTED: laminin subunit gamma-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 1094 7.9e-118 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.25866 BP_3 2315.05 7.35 15471 642917283 XP_008199234.1 4380 0.0e+00 PREDICTED: laminin subunit gamma-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 3130 0.0e+00 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 PF01695//PF00927//PF02732//PF08496 IstB-like ATP binding protein//Transglutaminase family, C-terminal ig like domain//ERCC4 domain//Peptidase family S49 N-terminal GO:0018149 peptide cross-linking GO:0003677//GO:0005524//GO:0003810//GO:0004252//GO:0004518 DNA binding//ATP binding//protein-glutamine gamma-glutamyltransferase activity//serine-type endopeptidase activity//nuclease activity GO:0005886 plasma membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.25867 BP_3 413.77 20.58 1261 642937435 XP_008198833.1 676 3.4e-68 PREDICTED: STAGA complex 65 subunit gamma-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O94864 197 4.8e-14 STAGA complex 65 subunit gamma OS=Homo sapiens GN=SUPT7L PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.25868 BP_3 347.60 16.55 1304 91089157 XP_973708.1 545 5.4e-53 PREDICTED: uncharacterized protein LOC662524 [Tribolium castaneum]>gi|270012450|gb|EFA08898.1| hypothetical protein TcasGA2_TC006599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0032222//GO:1903818//GO:0030431 regulation of synaptic transmission, cholinergic//positive regulation of voltage-gated potassium channel activity//sleep GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.25869 BP_3 36.00 0.80 2450 642923389 XP_008193727.1 498 2.9e-47 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum]>gi|270007632|gb|EFA04080.1| hypothetical protein TcasGA2_TC014314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08678 184 3.0e-12 Adenylate cyclase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYR1 PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.25870 BP_3 3.00 0.41 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25872 BP_3 3.00 3.48 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25874 BP_3 92.00 7.69 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25877 BP_3 1205.00 15.74 3981 642935391 XP_008197992.1 3335 0.0e+00 PREDICTED: protein expanded [Tribolium castaneum]>gi|270013880|gb|EFA10328.1| hypothetical protein TcasGA2_TC012545 [Tribolium castaneum] 642935390 XM_008199770.1 356 0 PREDICTED: Tribolium castaneum protein expanded (LOC659267), mRNA K16683 EX protein expanded http://www.genome.jp/dbget-bin/www_bget?ko:K16683 Q07436 508 1.3e-49 Protein expanded OS=Drosophila melanogaster GN=ex PE=1 SV=3 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG4371 Membrane-associated protein tyrosine phosphatase PTP-BAS and related proteins, contain FERM domain Cluster-8309.25878 BP_3 990.07 38.29 1538 642928832 XP_008195580.1 1542 1.6e-168 PREDICTED: activating signal cointegrator 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15650 461 1.4e-44 Activating signal cointegrator 1 OS=Homo sapiens GN=TRIP4 PE=1 SV=4 PF06221 Putative zinc finger motif, C2HC5-type GO:0006355 regulation of transcription, DNA-templated GO:0008270 zinc ion binding GO:0005634 nucleus KOG2845 Activating signal cointegrator 1 Cluster-8309.25880 BP_3 32.00 4.43 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25882 BP_3 673.30 13.62 2675 642919741 XP_970851.2 1511 1.1e-164 PREDICTED: protein daughter of sevenless [Tribolium castaneum]>gi|270005903|gb|EFA02351.1| hypothetical protein TcasGA2_TC008021 [Tribolium castaneum] -- -- -- -- -- K09593 GAB1 GRB2-associated-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09593 Q9VZZ9 380 6.2e-35 Protein daughter of sevenless OS=Drosophila melanogaster GN=dos PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25883 BP_3 148.00 9.85 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25884 BP_3 2441.27 80.69 1750 546681944 ERL91940.1 595 1.2e-58 hypothetical protein D910_09263, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0030431//GO:1903818//GO:0032222//GO:0016310//GO:0009069//GO:0007178 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic//phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.25886 BP_3 2.00 0.92 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25890 BP_3 41.47 0.36 5788 642916861 XP_008199532.1 881 2.6e-91 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270003078|gb|EEZ99525.1| hypothetical protein TcasGA2_TC000107 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 497 3.6e-48 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01118//PF01370//PF06756//PF03015//PF00033 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Chorion protein S19 C-terminal//Male sterility protein//Cytochrome b/b6/petB GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0022904//GO:0007275//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//respiratory electron transport chain//multicellular organismal development//estrogen metabolic process GO:0080019//GO:0016620//GO:0050662//GO:0003854//GO:0016616//GO:0003824//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//NAD binding GO:0042600//GO:0016020 chorion//membrane KOG1221 Acyl-CoA reductase Cluster-8309.25891 BP_3 37.00 1.40 1568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25892 BP_3 285.49 3.50 4227 478252787 ENN73180.1 1403 5.6e-152 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 4.8e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4780 Uncharacterized conserved protein Cluster-8309.25895 BP_3 7.37 1.05 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25897 BP_3 61.03 0.60 5177 642914074 XP_008201534.1 354 3.0e-30 PREDICTED: uncharacterized protein LOC658486 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25898 BP_3 1220.17 23.36 2809 642925510 XP_008194580.1 2213 4.5e-246 PREDICTED: proton-coupled folate transporter [Tribolium castaneum]>gi|270008860|gb|EFA05308.1| hypothetical protein TcasGA2_TC015466 [Tribolium castaneum] 749780227 XM_011146261.1 51 5.66605e-15 PREDICTED: Harpegnathos saltator solute carrier family 46 member 3-like (LOC105186216), mRNA K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q6DCX5 259 7.0e-21 Proton-coupled folate transporter OS=Xenopus laevis GN=slc46a1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.25899 BP_3 37.50 0.84 2453 170060164 XP_001865682.1 174 1.1e-09 galactose-specific C-type lectin [Culex quinquefasciatus]>gi|167878689|gb|EDS42072.1| galactose-specific C-type lectin [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.259 BP_3 30.00 3.00 774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25901 BP_3 3.35 0.34 766 759068460 XP_011343733.1 175 2.5e-10 PREDICTED: longitudinals lacking protein, isoform G-like isoform X13 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- Q9V5M3 129 2.3e-06 Longitudinals lacking protein, isoforms N/O/W/X/Y OS=Drosophila melanogaster GN=lola PE=1 SV=3 PF02892//PF00096//PF13465 BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.25902 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25906 BP_3 1787.90 8.93 9946 642922511 XP_008193204.1 9536 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X3 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.54524e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1775 4.0e-196 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF00658//PF04625//PF00632//PF11547 Poly-adenylate binding protein, unique domain//DEC-1 protein, N-terminal region//HECT-domain (ubiquitin-transferase)//E3 ubiquitin ligase EDD GO:0016567//GO:0007304 protein ubiquitination//chorion-containing eggshell formation GO:0004842//GO:0043130//GO:0005213//GO:0003723 ubiquitin-protein transferase activity//ubiquitin binding//structural constituent of chorion//RNA binding GO:0042600//GO:0005576 chorion//extracellular region KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.25907 BP_3 1.00 1.03 330 642922507 XP_008193202.1 237 7.0e-18 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 175 4.5e-12 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF12009//PF00632 Telomerase ribonucleoprotein complex - RNA binding domain//HECT-domain (ubiquitin-transferase) GO:0006278//GO:0016567 RNA-dependent DNA replication//protein ubiquitination GO:0004842//GO:0003964 ubiquitin-protein transferase activity//RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.25909 BP_3 13.19 3.39 479 642912272 XP_008200632.1 161 6.6e-09 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2591 BP_3 23288.00 416.92 2984 270003610 EFA00058.1 615 9.4e-61 hypothetical protein TcasGA2_TC002866 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain GO:0006520 cellular amino acid metabolic process GO:0016597//GO:0016743 amino acid binding//carboxyl- or carbamoyltransferase activity -- -- -- -- Cluster-8309.25910 BP_3 32.52 1.28 1514 91088445 XP_968690.1 775 1.3e-79 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 457 4.1e-44 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF13414//PF13176//PF04658//PF13371//PF07497//PF00515//PF13174//PF13181 TPR repeat//Tetratricopeptide repeat//TAFII55 protein conserved region//Tetratricopeptide repeat//Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0016567//GO:0006367//GO:0006353 protein ubiquitination//transcription initiation from RNA polymerase II promoter//DNA-templated transcription, termination GO:0005515//GO:0004842//GO:0003723 protein binding//ubiquitin-protein transferase activity//RNA binding GO:0000151//GO:0005669 ubiquitin ligase complex//transcription factor TFIID complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.25913 BP_3 9.96 0.60 1089 642934204 XP_008199651.1 454 1.6e-42 PREDICTED: gem-associated protein 2 [Tribolium castaneum] -- -- -- -- -- K13130 SIP1, GEMIN2 survival of motor neuron protein-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13130 O14893 195 7.1e-14 Gem-associated protein 2 OS=Homo sapiens GN=GEMIN2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25914 BP_3 4164.12 141.12 1714 642933377 XP_008197391.1 1114 7.4e-119 PREDICTED: uncharacterized protein LOC660130 isoform X2 [Tribolium castaneum] 642933376 XM_008199169.1 245 4.91487e-123 PREDICTED: Tribolium castaneum uncharacterized LOC660130 (LOC660130), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00822//PF06687//PF13903//PF00335//PF03419 PMP-22/EMP/MP20/Claudin family//SUR7/PalI family//PMP-22/EMP/MP20/Claudin tight junction//Tetraspanin family//Sporulation factor SpoIIGA GO:0030436//GO:0006508 asexual sporulation//proteolysis GO:0004190 aspartic-type endopeptidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.25919 BP_3 2390.56 42.96 2974 91086799 XP_973439.1 2962 0.0e+00 PREDICTED: protein O-mannosyl-transferase 2 [Tribolium castaneum] 759111195 XM_011357078.1 54 1.2903e-16 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q29IL2 2307 2.4e-258 Protein O-mannosyl-transferase 2 OS=Drosophila pseudoobscura pseudoobscura GN=tw PE=3 SV=1 PF15886//PF02366//PF02815 Carbohydrate binding domain (family 32)//Dolichyl-phosphate-mannose-protein mannosyltransferase//MIR domain GO:0006493 protein O-linked glycosylation GO:0030246//GO:0000030 carbohydrate binding//mannosyltransferase activity GO:0016020//GO:0000136 membrane//alpha-1,6-mannosyltransferase complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.2592 BP_3 7478.19 516.94 989 270003610 EFA00058.1 229 1.8e-16 hypothetical protein TcasGA2_TC002866 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25920 BP_3 255.12 5.18 2666 642924514 XP_008194327.1 920 3.6e-96 PREDICTED: nuclear fragile X mental retardation-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXX8 333 1.7e-29 Nuclear fragile X mental retardation-interacting protein 1 OS=Mus musculus GN=Nufip1 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25921 BP_3 94.00 2.87 1870 91086799 XP_973439.1 1673 1.2e-183 PREDICTED: protein O-mannosyl-transferase 2 [Tribolium castaneum] -- -- -- -- -- K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q29IL2 1218 2.9e-132 Protein O-mannosyl-transferase 2 OS=Drosophila pseudoobscura pseudoobscura GN=tw PE=3 SV=1 PF02815//PF02366 MIR domain//Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0006493 protein O-linked glycosylation GO:0000030 mannosyltransferase activity GO:0016020//GO:0000136 membrane//alpha-1,6-mannosyltransferase complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.25922 BP_3 370.03 5.70 3423 270000870 EEZ97317.1 1789 8.0e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.4026e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.5e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.25924 BP_3 2656.60 71.09 2093 642919219 XP_969254.2 711 4.9e-72 PREDICTED: peroxiredoxin-5, mitochondrial [Tribolium castaneum] -- -- -- -- -- K11187 PRDX5 peroxiredoxin 5, atypical 2-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11187 Q9GLW9 460 2.6e-44 Peroxiredoxin-5, mitochondrial OS=Papio hamadryas GN=PRDX5 PE=2 SV=1 PF00578//PF00076//PF16367//PF08534 AhpC/TSA family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Redoxin GO:0055114 oxidation-reduction process GO:0016491//GO:0003676//GO:0016209 oxidoreductase activity//nucleic acid binding//antioxidant activity -- -- KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin Cluster-8309.25926 BP_3 7.67 0.69 825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25927 BP_3 2.00 0.52 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25928 BP_3 56.03 3.83 996 478249796 ENN70303.1 448 7.3e-42 hypothetical protein YQE_12814, partial [Dendroctonus ponderosae] -- -- -- -- -- K04403 MAP3K7IP1, TAB1 TAK1-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04403 Q8CF89 139 2.0e-07 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Mus musculus GN=Tab1 PE=1 SV=2 PF08119 Scorpion acidic alpha-KTx toxin family GO:0006810//GO:0009405 transport//pathogenesis GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.25929 BP_3 36.97 2.87 913 478249796 ENN70303.1 508 7.4e-49 hypothetical protein YQE_12814, partial [Dendroctonus ponderosae] -- -- -- -- -- K04403 MAP3K7IP1, TAB1 TAK1-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04403 Q8CF89 154 3.4e-09 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Mus musculus GN=Tab1 PE=1 SV=2 PF08119 Scorpion acidic alpha-KTx toxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.2593 BP_3 94.14 4.55 1290 642929176 XP_008195725.1 1199 7.8e-129 PREDICTED: syntaxin-16 [Tribolium castaneum] -- -- -- -- -- K08489 STX16 syntaxin 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08489 Q8BVI5 576 5.6e-58 Syntaxin-16 OS=Mus musculus GN=Stx16 PE=1 SV=3 PF00804//PF05739//PF00957 Syntaxin//SNARE domain//Synaptobrevin GO:0016192 vesicle-mediated transport GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0809 SNARE protein TLG2/Syntaxin 16 Cluster-8309.25930 BP_3 97.78 3.39 1681 332372540 AEE61412.1 1212 3.2e-130 unknown [Dendroctonus ponderosae] -- -- -- -- -- K04403 MAP3K7IP1, TAB1 TAK1-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04403 Q15750 641 2.1e-65 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens GN=TAB1 PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.25931 BP_3 25.01 1.08 1408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25932 BP_3 86.19 1.16 3872 478254875 ENN75111.1 1428 6.5e-155 hypothetical protein YQE_08424, partial [Dendroctonus ponderosae] 642926583 XM_962896.2 307 3.84232e-157 PREDICTED: Tribolium castaneum lipoma-preferred partner homolog (LOC656358), transcript variant X2, mRNA K16676 LPP lipoma-prefererred partner http://www.genome.jp/dbget-bin/www_bget?ko:K16676 Q5F464 812 7.2e-85 Lipoma-preferred partner homolog OS=Gallus gallus GN=LPP PE=2 SV=1 PF00412//PF01080//PF06467//PF03348 LIM domain//Presenilin//MYM-type Zinc finger with FCS sequence motif//Serine incorporator (Serinc) -- -- GO:0004190//GO:0008270 aspartic-type endopeptidase activity//zinc ion binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.25934 BP_3 12.56 0.44 1680 642913250 XP_008201456.1 1439 1.5e-156 PREDICTED: probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum] 585692231 XM_006821346.1 56 5.58661e-18 PREDICTED: Saccoglossus kowalevskii probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase-like (LOC102807371), mRNA K03849 ALG8 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03849 Q9BVK2 1060 5.5e-114 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Homo sapiens GN=ALG8 PE=1 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG2576 Glucosyltransferase - Alg8p Cluster-8309.25936 BP_3 70.24 0.68 5282 91086067 XP_974022.1 2736 1.9e-306 PREDICTED: snake venom 5'-nucleotidase isoform X1 [Tribolium castaneum]>gi|270009911|gb|EFA06359.1| hypothetical protein TcasGA2_TC009234 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 O34313 387 1.9e-35 Trifunctional nucleotide phosphoesterase protein YfkN OS=Bacillus subtilis (strain 168) GN=yfkN PE=1 SV=1 PF00149//PF02872 Calcineurin-like phosphoesterase//5'-nucleotidase, C-terminal domain GO:0009166 nucleotide catabolic process GO:0016787 hydrolase activity -- -- KOG4697 Integral membrane protein involved in transport between the late Golgi and endosome Cluster-8309.25939 BP_3 1167.97 9.58 6168 91094947 XP_968721.1 2301 6.1e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- KOG2432 Uncharacterized conserved protein Cluster-8309.2594 BP_3 21.86 1.16 1202 642929176 XP_008195725.1 1064 3.3e-113 PREDICTED: syntaxin-16 [Tribolium castaneum] -- -- -- -- -- K08489 STX16 syntaxin 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08489 Q8BVI5 525 4.3e-52 Syntaxin-16 OS=Mus musculus GN=Stx16 PE=1 SV=3 PF00015//PF05739//PF00957//PF00804 Methyl-accepting chemotaxis protein (MCP) signalling domain//SNARE domain//Synaptobrevin//Syntaxin GO:0016192//GO:0007165 vesicle-mediated transport//signal transduction GO:0005515//GO:0004871 protein binding//signal transducer activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0809 SNARE protein TLG2/Syntaxin 16 Cluster-8309.25944 BP_3 807.00 61.62 923 91079624 XP_967576.1 777 4.8e-80 PREDICTED: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Tribolium castaneum]>gi|642917723|ref|XP_008191346.1| PREDICTED: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Tribolium castaneum]>gi|270004471|gb|EFA00919.1| hypothetical protein TcasGA2_TC003825 [Tribolium castaneum] -- -- -- -- -- K09578 PIN1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09578 P54353 517 2.8e-51 Putative peptidyl-prolyl cis-trans isomerase dodo OS=Drosophila melanogaster GN=dod PE=2 SV=3 PF13145//PF00639//PF00397 PPIC-type PPIASE domain//PPIC-type PPIASE domain//WW domain GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755//GO:0016853//GO:0005515 peptidyl-prolyl cis-trans isomerase activity//isomerase activity//protein binding -- -- KOG3259 Peptidyl-prolyl cis-trans isomerase Cluster-8309.25945 BP_3 281.47 2.87 5021 270014603 EFA11051.1 3157 0.0e+00 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] 195445683 XM_002070402.1 103 1.26286e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2242 1.4e-250 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00782//PF00041//PF00102 Dual specificity phosphatase, catalytic domain//Fibronectin type III domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515//GO:0008138 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.25946 BP_3 510.18 5.35 4885 270014603 EFA11051.1 3565 0.0e+00 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] 195445683 XM_002070402.1 103 1.22841e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2408 7.8e-270 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00041//PF00102//PF00782 Fibronectin type III domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515//GO:0008138 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.25949 BP_3 63.03 2.56 1479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2595 BP_3 4.00 0.45 723 548539 Q03276.1 210 2.1e-14 RecName: Full=Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1; AltName: Full=Retrovirus-related Pol polyprotein from type I retrotransposable element R1; Includes: RecName: Full=Reverse transcriptase; Includes: RecName: Full=Endonuclease, partial [Popillia japonica]>gi|160750|gb|AAA29783.1| reverse transcriptase, partial [Popillia japonica] -- -- -- -- -- -- -- -- -- Q03276 210 8.6e-16 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Fragment) OS=Popillia japonica PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25952 BP_3 59.86 0.82 3802 642932100 XP_008196854.1 1534 3.3e-167 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.25173e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.9e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF07525//PF00622//PF01213 SOCS box//SPRY domain//Adenylate cyclase associated (CAP) N terminal GO:0035556//GO:0007010 intracellular signal transduction//cytoskeleton organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.25955 BP_3 31.62 1.11 1665 642933484 XP_973892.2 854 1.0e-88 PREDICTED: soluble calcium-activated nucleotidase 1 [Tribolium castaneum] -- -- -- -- -- K12304 CANT1 soluble calcium-activated nucleotidase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12304 Q8VCF1 549 9.7e-55 Soluble calcium-activated nucleotidase 1 OS=Mus musculus GN=Cant1 PE=2 SV=1 PF06079 Apyrase -- -- GO:0005509//GO:0016462 calcium ion binding//pyrophosphatase activity -- -- KOG4494 Cell surface ATP diphosphohydrolase Apyrase Cluster-8309.25958 BP_3 70.05 1.45 2616 91087855 XP_968688.1 2489 4.1e-278 PREDICTED: vacuolar protein sorting-associated protein 33A [Tribolium castaneum]>gi|270012007|gb|EFA08455.1| hypothetical protein TcasGA2_TC006102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63615 1434 3.7e-157 Vacuolar protein sorting-associated protein 33A OS=Rattus norvegicus GN=Vps33a PE=1 SV=1 PF00995//PF00895 Sec1 family//ATP synthase protein 8 GO:0015986//GO:0015992//GO:0006904//GO:0016192 ATP synthesis coupled proton transport//proton transport//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG1302 Vacuolar sorting protein VPS33/slp1 (Sec1 family) Cluster-8309.25959 BP_3 4.00 3.31 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25960 BP_3 55.88 0.85 3448 642923271 XP_008193684.1 2245 1.1e-249 PREDICTED: protein FAN-like [Tribolium castaneum]>gi|642923273|ref|XP_008193685.1| PREDICTED: protein FAN-like [Tribolium castaneum] -- -- -- -- -- K18953 NSMAF, FAN factor associated with neutral sphingomyelinase activation http://www.genome.jp/dbget-bin/www_bget?ko:K18953 Q92636 1089 4.9e-117 Protein FAN OS=Homo sapiens GN=NSMAF PE=1 SV=2 PF11605//PF00400//PF16836//PF07569//PF08728 Vacuolar protein sorting protein 36 Vps36//WD domain, G-beta repeat//Shu complex component Psy3, DNA-binding description//TUP1-like enhancer of split//CRT10 GO:0000725//GO:0006355//GO:0006357 recombinational repair//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0043130//GO:0032266 protein binding//ubiquitin binding//phosphatidylinositol-3-phosphate binding GO:0005634//GO:0097196 nucleus//Shu complex KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.25967 BP_3 59.45 0.98 3216 91078858 XP_972061.1 1822 1.1e-200 PREDICTED: putative serine protease K12H4.7 [Tribolium castaneum] 642916112 XM_966968.2 67 8.28718e-24 PREDICTED: Tribolium castaneum putative serine protease K12H4.7 (LOC660762), mRNA -- -- -- -- P90893 781 2.4e-81 Putative serine protease F56F10.1 OS=Caenorhabditis elegans GN=F56F10.1 PE=1 SV=2 PF05577//PF09138 Serine carboxypeptidase S28//Urm1 (Ubiquitin related modifier) GO:0006508//GO:0034227 proteolysis//tRNA thio-modification GO:0008236 serine-type peptidase activity GO:0005737 cytoplasm KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.25972 BP_3 581.00 6.01 4948 642919861 XP_008192099.1 1398 2.5e-151 PREDICTED: protein cramped isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRH6 770 6.8e-80 Translation factor waclaw, mitochondrial OS=Drosophila melanogaster GN=waw PE=3 SV=2 PF01926//PF00735//PF08477//PF00025//PF10662//PF00071//PF09589 50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation//Ras family//HrpA pilus formation protein GO:0006576//GO:0009405//GO:0007264 cellular biogenic amine metabolic process//pathogenesis//small GTPase mediated signal transduction GO:0005525//GO:0005524 GTP binding//ATP binding GO:0005615 extracellular space KOG0462 Elongation factor-type GTP-binding protein Cluster-8309.25973 BP_3 156.56 3.21 2646 642920764 XP_008192550.1 1683 1.2e-184 PREDICTED: translation factor GUF1 homolog, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0WXB8 1437 1.7e-157 Translation factor GUF1 homolog, mitochondrial OS=Culex quinquefasciatus GN=CPIJ012086 PE=3 SV=1 PF01386//PF03144//PF06377 Ribosomal L25p family//Elongation factor Tu domain 2//Adipokinetic hormone GO:0042254//GO:0006412//GO:0007165 ribosome biogenesis//translation//signal transduction GO:0005525//GO:0003735//GO:0005179//GO:0008097 GTP binding//structural constituent of ribosome//hormone activity//5S rRNA binding GO:0005840 ribosome KOG0462 Elongation factor-type GTP-binding protein Cluster-8309.25974 BP_3 1602.14 33.70 2583 642912647 XP_008200948.1 315 5.0e-26 PREDICTED: CREB/ATF bZIP transcription factor-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05791//PF01166//PF13631//PF01253//PF07716//PF00170 Bacillus haemolytic enterotoxin (HBL)//TSC-22/dip/bun family//Cytochrome b(N-terminal)/b6/petB//Translation initiation factor SUI1//Basic region leucine zipper//bZIP transcription factor GO:0006413//GO:0006118//GO:0006355//GO:0009405//GO:0006446 translational initiation//obsolete electron transport//regulation of transcription, DNA-templated//pathogenesis//regulation of translational initiation GO:0043565//GO:0009055//GO:0003700//GO:0003743//GO:0016491 sequence-specific DNA binding//electron carrier activity//transcription factor activity, sequence-specific DNA binding//translation initiation factor activity//oxidoreductase activity GO:0016020//GO:0005840//GO:0005667 membrane//ribosome//transcription factor complex -- -- Cluster-8309.25976 BP_3 35.50 1.21 1700 642940380 XP_008190315.1 501 8.9e-48 PREDICTED: uncharacterized protein LOC103312157, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25977 BP_3 26.17 0.36 3790 189239475 XP_975363.2 691 1.8e-69 PREDICTED: atlastin [Tribolium castaneum]>gi|270010557|gb|EFA07005.1| hypothetical protein TcasGA2_TC009975 [Tribolium castaneum] -- -- -- -- -- K17339 ATL atlastin http://www.genome.jp/dbget-bin/www_bget?ko:K17339 Q9VC57 618 2.2e-62 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 PF02263 Guanylate-binding protein, N-terminal domain GO:0006184 obsolete GTP catabolic process GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG2037 Guanylate-binding protein Cluster-8309.25979 BP_3 77.35 1.46 2842 91079112 XP_975371.1 1029 8.9e-109 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 1.3e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF04879//PF03370//PF03423//PF16760 Molybdopterin oxidoreductase Fe4S4 domain//Carbohydrate/starch-binding module (family 21)//Carbohydrate binding domain (family 25)//Starch/carbohydrate-binding module (family 53) GO:0055114 oxidation-reduction process GO:2001070//GO:0005515//GO:0016491 starch binding//protein binding//oxidoreductase activity -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.2598 BP_3 2.00 0.42 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25980 BP_3 601.00 9.86 3231 642936791 XP_008198583.1 2256 5.3e-251 PREDICTED: parafibromin [Tribolium castaneum] 242014564 XM_002427912.1 162 1.28897e-76 Pediculus humanus corporis parafibromin, putative, mRNA K15175 CDC73 parafibromin http://www.genome.jp/dbget-bin/www_bget?ko:K15175 Q5ZLM0 1548 2.7e-170 Parafibromin OS=Gallus gallus GN=CDC73 PE=2 SV=1 PF00740 Parvovirus coat protein VP2 -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid KOG3786 RNA polymerase II assessory factor Cdc73p Cluster-8309.25982 BP_3 266.91 8.21 1859 270009743 EFA06191.1 1602 2.1e-175 hypothetical protein TcasGA2_TC009040 [Tribolium castaneum] 805761554 XM_012298644.1 131 1.25816e-59 PREDICTED: Megachile rotundata CCA tRNA nucleotidyltransferase 1, mitochondrial (LOC100882545), transcript variant X2, mRNA K00974 cca tRNA nucleotidyltransferase (CCA-adding enzyme) http://www.genome.jp/dbget-bin/www_bget?ko:K00974 Q96Q11 1074 1.4e-115 CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=TRNT1 PE=1 SV=2 PF01743 Poly A polymerase head domain GO:0006396 RNA processing GO:0016779//GO:0003723 nucleotidyltransferase activity//RNA binding -- -- KOG2159 tRNA nucleotidyltransferase/poly(A) polymerase Cluster-8309.25983 BP_3 687.51 21.39 1841 270009743 EFA06191.1 1602 2.1e-175 hypothetical protein TcasGA2_TC009040 [Tribolium castaneum] 805761554 XM_012298644.1 131 1.24575e-59 PREDICTED: Megachile rotundata CCA tRNA nucleotidyltransferase 1, mitochondrial (LOC100882545), transcript variant X2, mRNA K00974 cca tRNA nucleotidyltransferase (CCA-adding enzyme) http://www.genome.jp/dbget-bin/www_bget?ko:K00974 Q96Q11 1074 1.4e-115 CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=TRNT1 PE=1 SV=2 PF01743 Poly A polymerase head domain GO:0006396 RNA processing GO:0016779//GO:0003723 nucleotidyltransferase activity//RNA binding -- -- KOG2159 tRNA nucleotidyltransferase/poly(A) polymerase Cluster-8309.25984 BP_3 14.00 0.81 1120 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25986 BP_3 531.24 14.37 2073 332374952 AEE62617.1 1251 1.2e-134 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CW42 421 8.4e-40 Mitochondrial amidoxime-reducing component 1 OS=Mus musculus GN=Marc1 PE=1 SV=2 PF03473 MOSC domain -- -- GO:0030151//GO:0030170//GO:0003824 molybdenum ion binding//pyridoxal phosphate binding//catalytic activity -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.25989 BP_3 140.89 9.25 1026 568255492 ETN64256.1 282 1.3e-22 hypothetical protein AND_003999 [Anopheles darlingi] -- -- -- -- -- -- -- -- -- P82596 163 3.4e-10 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4297 C-type lectin Cluster-8309.25991 BP_3 3.00 0.31 754 91090021 XP_967356.1 280 1.7e-22 PREDICTED: peroxiredoxin-1 [Tribolium castaneum]>gi|270014285|gb|EFA10733.1| hypothetical protein TcasGA2_TC012328 [Tribolium castaneum] -- -- -- -- -- K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9Z0V6 162 3.3e-10 Thioredoxin-dependent peroxide reductase, mitochondrial OS=Rattus norvegicus GN=Prdx3 PE=1 SV=2 PF00578//PF08534 AhpC/TSA family//Redoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0016491 antioxidant activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.25996 BP_3 967.28 11.05 4511 642912125 XP_008200817.1 1775 4.4e-195 PREDICTED: cell division cycle and apoptosis regulator protein 1-like [Tribolium castaneum] 572309672 XM_006620560.1 86 3.19692e-34 PREDICTED: Apis dorsata cell division cycle and apoptosis regulator protein 1-like (LOC102677857), transcript variant X2, mRNA -- -- -- -- Q8CH18 1238 3.4e-134 Cell division cycle and apoptosis regulator protein 1 OS=Mus musculus GN=Ccar1 PE=1 SV=1 PF01247 Ribosomal protein L35Ae GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG4246 Predicted DNA-binding protein, contains SAP domain Cluster-8309.25999 BP_3 1686.29 8.43 9932 642918833 XP_008191605.1 8700 0.0e+00 PREDICTED: myotubularin-related protein 13 isoform X4 [Tribolium castaneum]>gi|270005687|gb|EFA02135.1| hypothetical protein TcasGA2_TC007785 [Tribolium castaneum] 642918832 XM_008193383.1 1567 0 PREDICTED: Tribolium castaneum myotubularin-related protein 13 (LOC659622), transcript variant X4, mRNA K18061 SBF1_2, MTMR5_13 myotubularin-related protein 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K18061 Q86WG5 3686 0.0e+00 Myotubularin-related protein 13 OS=Homo sapiens GN=SBF2 PE=1 SV=1 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0016311//GO:0035556 dephosphorylation//intracellular signal transduction GO:0005543//GO:0046872//GO:0016791 phospholipid binding//metal ion binding//phosphatase activity GO:0005622 intracellular KOG1090 Predicted dual-specificity phosphatase Cluster-8309.26 BP_3 1.00 0.33 436 676449883 XP_009052198.1 247 6.4e-19 hypothetical protein LOTGIDRAFT_226820 [Lottia gigantea]>gi|556108473|gb|ESO97125.1| hypothetical protein LOTGIDRAFT_226820 [Lottia gigantea] -- -- -- -- -- K14076 PNLIPRP3, PLRP3 pancreatic lipase-related protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14076 Q17RR3 194 3.7e-14 Pancreatic lipase-related protein 3 OS=Homo sapiens GN=PNLIPRP3 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2600 BP_3 70.00 12.53 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606 Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26003 BP_3 396.55 12.03 1881 189240485 XP_967921.2 1677 4.2e-184 PREDICTED: poly(A)-specific ribonuclease PARN [Tribolium castaneum]>gi|270011407|gb|EFA07855.1| hypothetical protein TcasGA2_TC005425 [Tribolium castaneum] -- -- -- -- -- K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 P69341 1069 5.5e-115 Poly(A)-specific ribonuclease PARN OS=Bos taurus GN=PARN PE=1 SV=2 PF01424//PF05669//PF08675//PF04857//PF14993 R3H domain//SOH1//RNA binding domain//CAF1 family ribonuclease//Neuropeptide S precursor protein GO:0007218//GO:0006355//GO:0051252//GO:0006402 neuropeptide signaling pathway//regulation of transcription, DNA-templated//regulation of RNA metabolic process//mRNA catabolic process GO:1901363//GO:0004535//GO:0003676//GO:0097159//GO:0046872//GO:0001104//GO:0003723 heterocyclic compound binding//poly(A)-specific ribonuclease activity//nucleic acid binding//organic cyclic compound binding//metal ion binding//RNA polymerase II transcription cofactor activity//RNA binding GO:0005576//GO:0005737//GO:0005634//GO:0016592 extracellular region//cytoplasm//nucleus//mediator complex KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.26004 BP_3 30.00 1.30 1403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26005 BP_3 3.00 3.14 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26006 BP_3 164.00 2.52 3426 642915779 XP_008200075.1 2130 2.3e-236 PREDICTED: uncharacterized protein LOC103314829 [Tribolium castaneum]>gi|270003127|gb|EEZ99574.1| hypothetical protein TcasGA2_TC001560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02525 135 2.0e-06 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF13912//PF07776//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.26007 BP_3 236.38 7.29 1854 270003550 EEZ99997.1 666 7.1e-67 hypothetical protein TcasGA2_TC002800 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NEL2 155 5.3e-09 Ankyrin repeat domain-containing protein SOWAHB OS=Homo sapiens GN=SOWAHB PE=1 SV=1 PF12009 Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.26008 BP_3 4.00 0.69 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26010 BP_3 33.40 1.24 1588 642920497 XP_008192376.1 1710 5.3e-188 PREDICTED: head-specific guanylate cyclase [Tribolium castaneum]>gi|270005900|gb|EFA02348.1| hypothetical protein TcasGA2_TC008018 [Tribolium castaneum] 755945261 XM_011301432.1 167 1.04134e-79 PREDICTED: Fopius arisanus head-specific guanylate cyclase (LOC105264506), mRNA K12318 GUCY1A guanylate cyclase soluble subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K12318 Q07093 1335 6.7e-146 Head-specific guanylate cyclase OS=Drosophila melanogaster GN=Gycalpha99B PE=2 SV=2 PF07701//PF00522//PF00211 Heme NO binding associated//VPR/VPX protein//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0006144//GO:0019058 cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//purine nucleobase metabolic process//viral life cycle GO:0000166//GO:0004383//GO:0020037//GO:0016849 nucleotide binding//guanylate cyclase activity//heme binding//phosphorus-oxygen lyase activity GO:0005622//GO:0042025 intracellular//host cell nucleus KOG4171 Adenylate/guanylate kinase Cluster-8309.26011 BP_3 12871.12 978.11 926 642922849 XP_008200420.1 1108 2.0e-118 PREDICTED: C-type lectin isoform X1 [Tribolium castaneum] 815810415 XM_012370684.1 201 7.52364e-99 PREDICTED: Linepithema humile uncharacterized LOC105674405 (LOC105674405), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26012 BP_3 627.33 13.12 2596 642917050 XP_008191099.1 1801 2.4e-198 PREDICTED: ras-related GTP-binding protein C isoform X1 [Tribolium castaneum] 675669405 XM_002750631.3 99 1.08598e-41 PREDICTED: Callithrix jacchus Ras-related GTP binding C (RRAGC), mRNA K16186 RRAGC_D Ras-related GTP-binding protein C/D http://www.genome.jp/dbget-bin/www_bget?ko:K16186 Q99K70 1344 9.9e-147 Ras-related GTP-binding protein C OS=Mus musculus GN=Rragc PE=1 SV=1 PF00071//PF00025//PF04670//PF08477//PF01926 Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG3887 Predicted small GTPase involved in nuclear protein import Cluster-8309.26014 BP_3 1436.00 115.69 890 189234762 XP_001814757.1 989 1.2e-104 PREDICTED: transmembrane emp24 domain-containing protein eca [Tribolium castaneum]>gi|270001537|gb|EEZ97984.1| hypothetical protein TcasGA2_TC000379 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4GMC3 915 1.9e-97 Transmembrane emp24 domain-containing protein eca OS=Drosophila persimilis GN=eca PE=3 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1690 emp24/gp25L/p24 family of membrane trafficking proteins Cluster-8309.26015 BP_3 372.00 20.56 1164 332375120 AEE62701.1 1211 2.8e-130 unknown [Dendroctonus ponderosae]>gi|546671559|gb|ERL83821.1| hypothetical protein D910_01073 [Dendroctonus ponderosae]>gi|546683663|gb|ERL93441.1| hypothetical protein D910_10733 [Dendroctonus ponderosae] -- -- -- -- -- K02906 RP-L3, MRPL3, rplC large subunit ribosomal protein L3 http://www.genome.jp/dbget-bin/www_bget?ko:K02906 Q99N95 592 7.0e-60 39S ribosomal protein L3, mitochondrial OS=Mus musculus GN=Mrpl3 PE=2 SV=1 PF00297//PF12937 Ribosomal protein L3//F-box-like GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3141 Mitochondrial/chloroplast ribosomal protein L3 Cluster-8309.26016 BP_3 45.00 5.17 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26017 BP_3 487.34 12.98 2102 189237118 XP_972118.2 2235 9.4e-249 PREDICTED: serine/threonine-protein kinase polo [Tribolium castaneum]>gi|270008199|gb|EFA04647.1| polo [Tribolium castaneum] -- -- -- -- -- K06631 PLK1 polo-like kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06631 P52304 1705 1.1e-188 Serine/threonine-protein kinase polo OS=Drosophila melanogaster GN=polo PE=1 SV=2 PF00659//PF00069//PF07714 POLO box duplicated region//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005515//GO:0004672//GO:0004674//GO:0005524 protein binding//protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0575 Polo-like serine/threonine protein kinase Cluster-8309.26018 BP_3 290.10 6.26 2526 478249742 ENN70250.1 587 1.4e-57 hypothetical protein YQE_13033, partial [Dendroctonus ponderosae] -- -- -- -- -- K15455 KTI11, DPH3 diphthamide biosynthesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15455 Q9VGQ9 220 2.1e-16 DPH3 homolog OS=Drosophila melanogaster GN=CG14701 PE=3 SV=1 PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- KOG2923 Uncharacterized conserved protein Cluster-8309.2602 BP_3 361.00 16.66 1336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26020 BP_3 55.52 0.92 3202 332373686 AEE61984.1 384 6.2e-34 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 131 5.5e-06 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26022 BP_3 85.00 21.73 480 270015440 EFA11888.1 215 3.7e-15 hypothetical protein TcasGA2_TC016001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26023 BP_3 2.00 45.50 223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26024 BP_3 14.05 0.87 1072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26025 BP_3 202.65 4.46 2484 642937356 XP_008198803.1 3064 0.0e+00 PREDICTED: raf homolog serine/threonine-protein kinase phl [Tribolium castaneum] 195447877 XM_002071375.1 63 1.0683e-21 Drosophila willistoni GK25150 (Dwil\GK25150), mRNA K02644 PHL pole hole http://www.genome.jp/dbget-bin/www_bget?ko:K02644 P11346 1860 1.4e-206 Raf homolog serine/threonine-protein kinase phl OS=Drosophila melanogaster GN=phl PE=1 SV=6 PF13949//PF00130//PF07649//PF04111//PF16326//PF07714//PF00069//PF02196//PF06293 ALIX V-shaped domain binding to HIV//Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain//Autophagy protein Apg6//ABC transporter C-terminal domain//Protein tyrosine kinase//Protein kinase domain//Raf-like Ras-binding domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0055114//GO:0035556//GO:0007165//GO:0006468//GO:0006914 oxidation-reduction process//intracellular signal transduction//signal transduction//protein phosphorylation//autophagy GO:0016773//GO:0004672//GO:0047134//GO:0005057//GO:0003677//GO:0005524//GO:0005515 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein-disulfide reductase activity//receptor signaling protein activity//DNA binding//ATP binding//protein binding GO:0016020 membrane KOG0193 Serine/threonine protein kinase RAF Cluster-8309.26026 BP_3 447.05 18.13 1480 91079010 XP_974804.1 837 8.5e-87 PREDICTED: putative inositol monophosphatase 3 [Tribolium castaneum]>gi|270004173|gb|EFA00621.1| hypothetical protein TcasGA2_TC003497 [Tribolium castaneum] -- -- -- -- -- K15759 IMPAD1, IMPA3 inositol monophosphatase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15759 Q29JH0 568 5.4e-57 Putative inositol monophosphatase 3 OS=Drosophila pseudoobscura pseudoobscura GN=GA13929 PE=3 SV=2 PF04843//PF00459 Herpesvirus tegument protein, N-terminal conserved region//Inositol monophosphatase family GO:0006508//GO:0046854 proteolysis//phosphatidylinositol phosphorylation GO:0008233 peptidase activity -- -- KOG3853 Inositol monophosphatase Cluster-8309.26028 BP_3 10.22 0.55 1182 332372582 AEE61433.1 454 1.7e-42 unknown [Dendroctonus ponderosae]>gi|478257378|gb|ENN77536.1| hypothetical protein YQE_05984, partial [Dendroctonus ponderosae]>gi|546685348|gb|ERL94875.1| hypothetical protein D910_12148 [Dendroctonus ponderosae] -- -- -- -- -- K01358 clpP, CLPP ATP-dependent Clp protease, protease subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01358 Q16740 402 7.7e-38 ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens GN=CLPP PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0840 ATP-dependent Clp protease, proteolytic subunit Cluster-8309.26029 BP_3 29.17 0.63 2537 642912116 XP_008200813.1 1247 4.2e-134 PREDICTED: inorganic pyrophosphatase isoform X1 [Tribolium castaneum] 755993244 XM_011315162.1 85 6.43071e-34 PREDICTED: Fopius arisanus inorganic pyrophosphatase (LOC105272929), mRNA K01507 ppa inorganic pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01507 O77460 949 6.1e-101 Inorganic pyrophosphatase OS=Drosophila melanogaster GN=Nurf-38 PE=1 SV=3 PF00719 Inorganic pyrophosphatase GO:0006796//GO:0006119 phosphate-containing compound metabolic process//oxidative phosphorylation GO:0004427//GO:0000287 inorganic diphosphatase activity//magnesium ion binding GO:0005737 cytoplasm KOG1626 Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 Cluster-8309.26030 BP_3 303.07 9.93 1763 642915894 XP_008190797.1 1918 4.5e-212 PREDICTED: uncharacterized protein LOC100142231 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26034 BP_3 497.10 7.51 3483 189237997 XP_001812912.1 1051 3.0e-111 PREDICTED: dehydrogenase/reductase SDR family protein 7-like [Tribolium castaneum]>gi|270006651|gb|EFA03099.1| hypothetical protein TcasGA2_TC013008 [Tribolium castaneum] -- -- -- -- -- K11166 DHRS7B dehydrogenase/reductase SDR family member 7B http://www.genome.jp/dbget-bin/www_bget?ko:K11166 Q7Q732 796 4.6e-83 Dehydrogenase/reductase SDR family protein 7-like OS=Anopheles gambiae GN=AGAP005532 PE=3 SV=3 PF14972//PF01370//PF00106//PF02882//PF12242//PF02558 Mitochondrial morphogenesis regulator//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Ketopantoate reductase PanE/ApbA GO:0046487//GO:0009396//GO:0015940//GO:0008152//GO:0055114//GO:0007005 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//pantothenate biosynthetic process//metabolic process//oxidation-reduction process//mitochondrion organization GO:0004488//GO:0016491//GO:0003824//GO:0050662//GO:0008677 methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity//catalytic activity//coenzyme binding//2-dehydropantoate 2-reductase activity GO:0031305 integral component of mitochondrial inner membrane KOG1205 Predicted dehydrogenase Cluster-8309.26035 BP_3 98.34 1.56 3321 189242339 XP_967217.2 1417 1.1e-153 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|642939487|ref|XP_008190837.1| PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270016564|gb|EFA13010.1| hypothetical protein TcasGA2_TC001975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 292 1.2e-24 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF01238//PF00560 Leucine rich repeat//Phosphomannose isomerase type I//Leucine Rich Repeat GO:0005975//GO:0006000//GO:0006013 carbohydrate metabolic process//fructose metabolic process//mannose metabolic process GO:0005515//GO:0004476//GO:0008270 protein binding//mannose-6-phosphate isomerase activity//zinc ion binding -- -- -- -- Cluster-8309.26038 BP_3 1.02 0.33 438 478256019 ENN76218.1 261 1.5e-20 hypothetical protein YQE_07185, partial [Dendroctonus ponderosae] -- -- -- -- -- K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q148N0 128 1.7e-06 2-oxoglutarate dehydrogenase, mitochondrial OS=Bos taurus GN=OGDH PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.2604 BP_3 35.99 0.59 3217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26040 BP_3 9.56 0.74 917 861633222 KMQ90883.1 149 3.1e-07 hypothetical protein RF55_9309 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26041 BP_3 66.41 11.93 560 642925742 XP_008201567.1 355 2.5e-31 PREDICTED: LOW QUALITY PROTEIN: protein strawberry notch [Tribolium castaneum] 642925741 XM_008203345.1 56 1.78692e-18 PREDICTED: Tribolium castaneum protein strawberry notch (LOC655369), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26044 BP_3 93.00 1.39 3513 270015833 EFA12281.1 427 7.0e-39 hypothetical protein TcasGA2_TC005266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01637//PF00665//PF13304//PF08651//PF00910//PF07962 Archaeal ATPase//Integrase core domain//AAA domain, putative AbiEii toxin, Type IV TA system//DASH complex subunit Duo1//RNA helicase//Replication Fork Protection Component Swi3 GO:0006974//GO:0007067//GO:0007049//GO:0048478//GO:0015074 cellular response to DNA damage stimulus//mitotic nuclear division//cell cycle//replication fork protection//DNA integration GO:0005524//GO:0003723//GO:0003724 ATP binding//RNA binding//RNA helicase activity GO:0005634//GO:0072686//GO:0042729 nucleus//mitotic spindle//DASH complex -- -- Cluster-8309.26046 BP_3 4.74 1.40 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26051 BP_3 202.00 8.10 1493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26054 BP_3 223.27 3.04 3836 642914933 XP_008190447.1 756 5.4e-77 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X1 [Tribolium castaneum] 170050238 XM_001859888.1 68 2.75338e-24 Culex quinquefasciatus conserved hypothetical protein, mRNA K11667 INO80C, IES6 INO80 complex subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K11667 Q6PI98 282 2.0e-23 INO80 complex subunit C OS=Homo sapiens GN=INO80C PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4137 Uncharacterized conserved protein Cluster-8309.26055 BP_3 65.17 1.29 2721 189237939 XP_001813105.1 493 1.2e-46 PREDICTED: ras-related protein Rab-5B [Tribolium castaneum]>gi|270008253|gb|EFA04701.1| Rab-protein 5 [Tribolium castaneum] 589949458 XM_006987325.1 126 1.11431e-56 PREDICTED: Peromyscus maniculatus bairdii RAB5B, member RAS oncogene family (Rab5b), mRNA K07888 RAB5B Ras-related protein Rab-5B http://www.genome.jp/dbget-bin/www_bget?ko:K07888 P61021 453 2.2e-43 Ras-related protein Rab-5B OS=Mus musculus GN=Rab5b PE=1 SV=1 PF00025//PF00071//PF16094//PF08477 ADP-ribosylation factor family//Ras family//Proteasome assembly chaperone 4//Ras of Complex, Roc, domain of DAPkinase GO:0043248//GO:0015031//GO:0007264 proteasome assembly//protein transport//small GTPase mediated signal transduction GO:0005525 GTP binding GO:0005783 endoplasmic reticulum KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.26056 BP_3 18.87 1.02 1185 189239772 XP_966744.2 421 1.2e-38 PREDICTED: tight junction protein ZO-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00330//PF03165 Aconitase family (aconitate hydratase)//MH1 domain GO:0008152//GO:0006355 metabolic process//regulation of transcription, DNA-templated -- -- GO:0005622 intracellular -- -- Cluster-8309.26057 BP_3 27.61 0.44 3330 189239692 XP_967139.2 1433 1.5e-155 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 65 1.11045e-22 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 929 1.7e-98 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF03293//PF00957//PF01080 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Synaptobrevin//Presenilin GO:0006351//GO:0019083//GO:0006144//GO:0016192//GO:0006206 transcription, DNA-templated//viral transcription//purine nucleobase metabolic process//vesicle-mediated transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0004190 DNA-directed RNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0016021//GO:0005730 integral component of membrane//nucleolus KOG2736 Presenilin Cluster-8309.26058 BP_3 15.00 1.04 989 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2606 BP_3 10.00 0.76 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26060 BP_3 33.07 1.27 1545 91083015 XP_974607.1 469 4.1e-44 PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|642923430|ref|XP_008193741.1| PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|270007020|gb|EFA03468.1| hypothetical protein TcasGA2_TC013464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 211 1.4e-15 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.26061 BP_3 417.79 7.66 2920 91078738 XP_967649.1 1032 4.1e-109 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] 195153530 XM_002017643.1 69 5.81007e-25 Drosophila persimilis GL17308 (Dper\GL17308), mRNA -- -- -- -- Q6DC39 632 4.0e-64 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.26063 BP_3 3.00 0.86 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05464 Phi-29-like late genes activator (early protein GP4) GO:0006206//GO:0006351//GO:0006355//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//regulation of transcription, DNA-templated//purine nucleobase metabolic process GO:0016987//GO:0003899 sigma factor activity//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.26065 BP_3 128.00 10.93 856 861633328 KMQ90923.1 323 1.9e-27 transposable element tc3 transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-8309.26066 BP_3 208.00 48.10 500 759051026 XP_011334612.1 563 1.7e-55 PREDICTED: uncharacterized protein LOC105277723 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26067 BP_3 323.00 7.24 2443 642910774 XP_008193404.1 944 5.5e-99 PREDICTED: ralA-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08773 RALBP1 RalA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08773 Q9VDG2 598 3.0e-60 RalA-binding protein 1 OS=Drosophila melanogaster GN=Rlip PE=1 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.26068 BP_3 11.00 0.90 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.26070 BP_3 11.00 0.42 1566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26071 BP_3 162.09 1.30 6320 780669505 XP_011694873.1 1341 1.3e-144 PREDICTED: methylcytosine dioxygenase TET2 isoform X2 [Wasmannia auropunctata] 642922119 XM_008194802.1 71 9.78189e-26 PREDICTED: Tribolium castaneum uncharacterized LOC103312925 (LOC103312925), mRNA -- -- -- -- M9NEY8 1073 6.4e-115 DNA N6-methyl adenine demethylase OS=Drosophila melanogaster GN=Tet PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26075 BP_3 98.52 3.34 1715 478251138 ENN71614.1 811 1.0e-83 hypothetical protein YQE_11713, partial [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q6RY07 418 1.6e-39 Acidic mammalian chitinase OS=Rattus norvegicus GN=Chia PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.26077 BP_3 10.49 1.49 631 642913478 XP_008201029.1 479 1.2e-45 PREDICTED: dolichol kinase [Tribolium castaneum] -- -- -- -- -- K00902 E2.7.1.108 dolichol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00902 Q8R2Y3 278 9.7e-24 Dolichol kinase OS=Mus musculus GN=Dolk PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2468 Dolichol kinase Cluster-8309.26078 BP_3 14.55 0.64 1393 478251220 ENN71694.1 312 6.0e-26 hypothetical protein YQE_11617, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26081 BP_3 209.69 2.56 4239 478253799 ENN74091.1 4823 0.0e+00 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 P29144 2726 9.1e-307 Tripeptidyl-peptidase 2 OS=Homo sapiens GN=TPP2 PE=1 SV=4 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.26083 BP_3 90.00 9.24 761 642933223 XP_008197314.1 386 8.6e-35 PREDICTED: uncharacterized protein LOC103314104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TYJ0 178 4.6e-12 General odorant-binding protein 71 OS=Anopheles gambiae GN=Obp71 PE=3 SV=4 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.26084 BP_3 154.14 1.33 5890 642939380 XP_008193163.1 2477 2.3e-276 PREDICTED: hemicentin-1 isoform X3 [Tribolium castaneum] 642939379 XM_008194941.1 105 1.14643e-44 PREDICTED: Tribolium castaneum hemicentin-1 (LOC660515), transcript variant X3, mRNA -- -- -- -- Q8WZ42 332 5.0e-29 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF00895//PF05510//PF00558//PF06377//PF13895//PF00957 ATP synthase protein 8//Sarcoglycan alpha/epsilon//Vpu protein//Adipokinetic hormone//Immunoglobulin domain//Synaptobrevin GO:0019076//GO:0016192//GO:0007165//GO:0015992//GO:0032801//GO:0015986//GO:0006812 viral release from host cell//vesicle-mediated transport//signal transduction//proton transport//receptor catabolic process//ATP synthesis coupled proton transport//cation transport GO:0005515//GO:0005179//GO:0005261//GO:0015078 protein binding//hormone activity//cation channel activity//hydrogen ion transmembrane transporter activity GO:0016021//GO:0016012//GO:0033644//GO:0000276 integral component of membrane//sarcoglycan complex//host cell membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.26087 BP_3 12.00 3.02 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26090 BP_3 51.60 0.98 2829 270013097 EFA09545.1 3781 0.0e+00 hypothetical protein TcasGA2_TC011654 [Tribolium castaneum] 194740873 XM_001952880.1 419 0 Drosophila ananassae GF17478 (Dana\GF17478), mRNA K13763 PDE6N cGMP-specific 3',5'-cyclic phosphodiesterase, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K13763 B4K9L4 3078 0.0e+00 cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila mojavensis GN=Pde6 PE=3 SV=1 PF13185//PF00233//PF01590//PF04542//PF13492 GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//Sigma-70 region 2//GAF domain GO:0006355//GO:0006352//GO:0007165//GO:0006144 regulation of transcription, DNA-templated//DNA-templated transcription, initiation//signal transduction//purine nucleobase metabolic process GO:0016987//GO:0003700//GO:0004114//GO:0003677//GO:0005515 sigma factor activity//transcription factor activity, sequence-specific DNA binding//3',5'-cyclic-nucleotide phosphodiesterase activity//DNA binding//protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.26091 BP_3 39.05 0.65 3192 91094219 XP_973249.1 584 4.0e-57 PREDICTED: uncharacterized protein C9orf85 homolog isoform X2 [Tribolium castaneum]>gi|270016216|gb|EFA12662.1| hypothetical protein TcasGA2_TC002245 [Tribolium castaneum] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q5TZ51 297 3.1e-25 Protein Mpv17 OS=Danio rerio GN=mpv17 PE=2 SV=1 PF01990//PF04117 ATP synthase (F/14-kDa) subunit//Mpv17 / PMP22 family GO:0034220 ion transmembrane transport -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.26092 BP_3 8.00 0.77 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26093 BP_3 481.56 5.28 4686 546674891 ERL86177.1 2545 2.4e-284 hypothetical protein D910_03590 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R3L5 704 2.9e-72 Solute carrier organic anion transporter family member 3A1 OS=Mus musculus GN=Slco3a1 PE=2 SV=1 PF00050//PF07648//PF09446//PF03137//PF07690 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain//VMA21-like domain//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0070072//GO:0055085//GO:0006810 vacuolar proton-transporting V-type ATPase complex assembly//transmembrane transport//transport GO:0005215//GO:0005515 transporter activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG3626 Organic anion transporter Cluster-8309.26095 BP_3 246.80 2.15 5834 642926198 XP_008194826.1 4970 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein castor homolog 1-like [Tribolium castaneum] 645021609 XM_008209379.1 386 0 PREDICTED: Nasonia vitripennis zinc finger protein castor homolog 1-like (LOC100116283), partial mRNA -- -- -- -- Q7M3M8 884 4.9e-93 Transcription factor castor OS=Drosophila melanogaster GN=cas PE=1 SV=2 PF06734//PF02178//PF09026 UL97//AT hook motif//Centromere protein B dimerisation domain GO:0016032//GO:0006355 viral process//regulation of transcription, DNA-templated GO:0003677//GO:0005524//GO:0003682//GO:0004672 DNA binding//ATP binding//chromatin binding//protein kinase activity GO:0005634//GO:0000785//GO:0000775 nucleus//chromatin//chromosome, centromeric region -- -- Cluster-8309.26096 BP_3 309.46 10.61 1698 576251521 AHH29345.1 433 6.8e-40 vacuolar H[+]-ATPase E subunit [Leptinotarsa decemlineata] -- -- -- -- -- K02150 ATPeV1E, ATP6E V-type H+-transporting ATPase subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K02150 P31402 292 6.3e-25 V-type proton ATPase subunit E OS=Manduca sexta GN=VHA26 PE=2 SV=1 PF01991 ATP synthase (E/31 kDa) subunit GO:0015992//GO:0006119//GO:0015991 proton transport//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961 proton-transporting ATPase activity, rotational mechanism GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1664 Vacuolar H+-ATPase V1 sector, subunit E Cluster-8309.26099 BP_3 155.00 15.92 761 91082423 XP_970313.1 900 2.1e-94 PREDICTED: DNA-directed RNA polymerase II subunit RPB7 [Tribolium castaneum]>gi|270007516|gb|EFA03964.1| hypothetical protein TcasGA2_TC014109 [Tribolium castaneum] -- -- -- -- -- K03015 RPB7, POLR2G DNA-directed RNA polymerase II subunit RPB7 http://www.genome.jp/dbget-bin/www_bget?ko:K03015 P62488 748 3.7e-78 DNA-directed RNA polymerase II subunit RPB7 OS=Mus musculus GN=Polr2g PE=2 SV=1 PF03876//PF00575 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//S1 RNA binding domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003676//GO:0003723//GO:0003899 nucleic acid binding//RNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3298 DNA-directed RNA polymerase subunit E' Cluster-8309.26102 BP_3 2131.56 38.97 2928 478257160 ENN77323.1 1838 1.4e-202 hypothetical protein YQE_06149, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IVI9 340 2.9e-30 Nostrin OS=Homo sapiens GN=NOSTRIN PE=1 SV=2 PF02185 Hr1 repeat GO:0007165 signal transduction -- -- -- -- KOG3158 HSP90 co-chaperone p23 Cluster-8309.26103 BP_3 56.19 3.35 1099 91087585 XP_971866.1 401 2.3e-36 PREDICTED: signal peptidase complex subunit 1 [Tribolium castaneum]>gi|270010698|gb|EFA07146.1| hypothetical protein TcasGA2_TC010137 [Tribolium castaneum] -- -- -- -- -- K12946 SPCS1 signal peptidase complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12946 Q9VAL0 285 2.6e-24 Signal peptidase complex subunit 1 OS=Drosophila melanogaster GN=Spase12 PE=1 SV=2 PF06645 Microsomal signal peptidase 12 kDa subunit (SPC12) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex KOG4112 Signal peptidase subunit Cluster-8309.26104 BP_3 121.23 2.28 2849 478253990 ENN74282.1 1734 1.6e-190 hypothetical protein YQE_09254, partial [Dendroctonus ponderosae]>gi|546673736|gb|ERL85292.1| hypothetical protein D910_02713 [Dendroctonus ponderosae] -- -- -- -- -- K06639 CDC14 cell division cycle 14 http://www.genome.jp/dbget-bin/www_bget?ko:K06639 Q6GQT0 1212 2.2e-131 Dual specificity protein phosphatase CDC14A OS=Mus musculus GN=Cdc14a PE=2 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.26105 BP_3 383.97 8.63 2436 91082801 XP_967900.1 2758 2.5e-309 PREDICTED: PAX3- and PAX7-binding protein 1 [Tribolium castaneum]>gi|270007581|gb|EFA04029.1| hypothetical protein TcasGA2_TC014258 [Tribolium castaneum] -- -- -- -- -- K13211 GCFC GC-rich sequence DNA-binding factor http://www.genome.jp/dbget-bin/www_bget?ko:K13211 P58501 803 5.0e-84 PAX3- and PAX7-binding protein 1 OS=Mus musculus GN=Paxbp1 PE=1 SV=3 PF07842 GC-rich sequence DNA-binding factor-like protein GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG2136 Transcriptional regulators binding to the GC-rich sequences Cluster-8309.26109 BP_3 119.25 0.80 7484 642927149 XP_008195158.1 330 2.6e-27 PREDICTED: uncharacterized protein LOC661334 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26110 BP_3 99.00 6.59 1016 304367616 ADM26622.1 870 8.6e-91 ferritin [Scylla paramamosain] 304367615 HM150719.1 748 0 Scylla paramamosain ferritin mRNA, complete cds K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 Q26061 681 2.9e-70 Ferritin OS=Pacifastacus leniusculus PE=1 SV=1 PF02915//PF00210 Rubrerythrin//Ferritin-like domain GO:0006879//GO:0055114 cellular iron ion homeostasis//oxidation-reduction process GO:0008199//GO:0046872//GO:0016491 ferric iron binding//metal ion binding//oxidoreductase activity -- -- KOG2332 Ferritin Cluster-8309.26113 BP_3 156.67 0.64 12086 642913340 XP_008195316.1 9080 0.0e+00 PREDICTED: WD repeat and FYVE domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270002019|gb|EEZ98466.1| hypothetical protein TcasGA2_TC000957 [Tribolium castaneum] 572266379 XM_006611237.1 593 0 PREDICTED: Apis dorsata WD repeat and FYVE domain-containing protein 3-like (LOC102679853), mRNA -- -- -- -- Q6VNB8 2989 0.0e+00 WD repeat and FYVE domain-containing protein 3 OS=Mus musculus GN=Wdfy3 PE=1 SV=1 PF01363//PF13742//PF00400 FYVE zinc finger//OB-fold nucleic acid binding domain//WD domain, G-beta repeat -- -- GO:0003676//GO:0005515//GO:0046872 nucleic acid binding//protein binding//metal ion binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.26115 BP_3 215.21 2.18 5059 642936176 XP_008198328.1 942 1.9e-98 PREDICTED: fibronectin type III domain-containing protein 4 [Tribolium castaneum] 194880702 XM_001974468.1 91 5.96234e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF08022 FAD-binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.26116 BP_3 11.82 0.79 1012 91080775 XP_968281.1 561 5.8e-55 PREDICTED: rab GDP dissociation inhibitor alpha [Tribolium castaneum]>gi|270005439|gb|EFA01887.1| hypothetical protein TcasGA2_TC007497 [Tribolium castaneum] -- -- -- -- -- K17255 GDI1_2 Rab GDP dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K17255 P21856 417 1.2e-39 Rab GDP dissociation inhibitor alpha OS=Bos taurus GN=GDI1 PE=1 SV=1 -- -- GO:0015031 protein transport GO:0005093 Rab GDP-dissociation inhibitor activity -- -- KOG1439 RAB proteins geranylgeranyltransferase component A (RAB escort protein) Cluster-8309.26117 BP_3 17.00 1.49 842 470401636 XP_004335606.1 349 1.9e-30 DnaJ family protein [Acanthamoeba castellanii str. Neff]>gi|440792370|gb|ELR13593.1| DnaJ family protein [Acanthamoeba castellanii str. Neff] 697091551 XM_009660214.1 664 0 Verticillium dahliae VdLs.17 psi1 partial mRNA K09510 DNAJB4 DnaJ homolog subfamily B member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09510 Q09912 404 3.2e-38 Protein psi1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=psi1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.26118 BP_3 29.10 2.37 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2612 BP_3 4.00 0.37 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26120 BP_3 57.80 0.44 6639 642923720 XP_008193855.1 1439 5.9e-156 PREDICTED: extended synaptotagmin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0FGR8 565 5.4e-56 Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2 PE=1 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.26126 BP_3 142.31 1.14 6325 478255041 ENN75273.1 1173 4.0e-125 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 658861642 XM_008415365.1 133 3.35087e-60 PREDICTED: Poecilia reticulata phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 1058 3.5e-113 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF15461//PF00520//PF01409 Beta-carotene 15,15'-dioxygenase//Ion transport protein//tRNA synthetases class II core domain (F) GO:0006418//GO:0006811//GO:0043039//GO:0055114//GO:0055085 tRNA aminoacylation for protein translation//ion transport//tRNA aminoacylation//oxidation-reduction process//transmembrane transport GO:0005216//GO:0004812//GO:0005524//GO:0000049//GO:0016702 ion channel activity//aminoacyl-tRNA ligase activity//ATP binding//tRNA binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016020//GO:0005737 membrane//cytoplasm KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.26128 BP_3 8.50 0.93 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26129 BP_3 2749.44 19.96 6931 270013942 EFA10390.1 1611 7.0e-176 hypothetical protein TcasGA2_TC012621 [Tribolium castaneum] 642935672 XM_969594.3 364 0 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 11 (LOC663555), mRNA K03036 PSMD11, RPN6 26S proteasome regulatory subunit N6 http://www.genome.jp/dbget-bin/www_bget?ko:K03036 Q7KLV9 1341 5.9e-146 26S proteasome non-ATPase regulatory subunit 11 OS=Drosophila melanogaster GN=Rpn6 PE=1 SV=1 PF01399//PF05823//PF05524 PCI domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//PEP-utilising enzyme, N-terminal GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.2613 BP_3 38.42 3.30 853 642934279 XP_008200904.1 323 1.9e-27 PREDICTED: centromere protein S-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D084 168 7.5e-11 Centromere protein S OS=Mus musculus GN=Apitd1 PE=2 SV=1 PF02969//PF00125//PF02291//PF04628 TATA box binding protein associated factor (TAF)//Core histone H2A/H2B/H3/H4//Transcription initiation factor IID, 31kD subunit//Sedlin, N-terminal conserved region GO:0006352//GO:0006888 DNA-templated transcription, initiation//ER to Golgi vesicle-mediated transport GO:0003677 DNA binding GO:0005634//GO:0005622 nucleus//intracellular -- -- Cluster-8309.26130 BP_3 315.83 6.44 2654 642919741 XP_970851.2 1468 1.0e-159 PREDICTED: protein daughter of sevenless [Tribolium castaneum]>gi|270005903|gb|EFA02351.1| hypothetical protein TcasGA2_TC008021 [Tribolium castaneum] -- -- -- -- -- K09593 GAB1 GRB2-associated-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09593 Q9VZZ9 369 1.2e-33 Protein daughter of sevenless OS=Drosophila melanogaster GN=dos PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26131 BP_3 16.00 1.91 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26133 BP_3 612.37 25.03 1471 478260052 ENN79837.1 816 2.3e-84 hypothetical protein YQE_03659, partial [Dendroctonus ponderosae]>gi|546676810|gb|ERL87756.1| hypothetical protein D910_05145 [Dendroctonus ponderosae] 556754727 XM_005972665.1 93 1.31811e-38 PREDICTED: Pantholops hodgsonii TRK-fused gene (TFG), mRNA K09292 TFG protein TFG http://www.genome.jp/dbget-bin/www_bget?ko:K09292 Q92734 475 3.3e-46 Protein TFG OS=Homo sapiens GN=TFG PE=1 SV=2 PF00564 PB1 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26135 BP_3 123.77 1.68 3843 546684171 ERL93876.1 1173 2.4e-125 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P57775 470 3.3e-45 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF00400//PF00646//PF01442//PF15966//PF12937//PF03357 WD domain, G-beta repeat//F-box domain//Apolipoprotein A1/A4/E domain//F-box//F-box-like//Snf7 GO:0007034//GO:0006869//GO:0042157 vacuolar transport//lipid transport//lipoprotein metabolic process GO:0005515//GO:0008289 protein binding//lipid binding GO:0005576 extracellular region KOG2911 Uncharacterized conserved protein Cluster-8309.26136 BP_3 142.00 4.43 1836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2614 BP_3 3.58 0.75 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26140 BP_3 19.62 3.14 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04851//PF00602 Type III restriction enzyme, res subunit//Influenza RNA-dependent RNA polymerase subunit PB1 GO:0006144//GO:0006351 purine nucleobase metabolic process//transcription, DNA-templated GO:0003968//GO:0005524//GO:0003677//GO:0016787 RNA-directed RNA polymerase activity//ATP binding//DNA binding//hydrolase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.26143 BP_3 111.30 5.95 1194 91079286 XP_972784.1 697 1.2e-70 PREDICTED: syntaxin-17 [Tribolium castaneum]>gi|270004314|gb|EFA00762.1| hypothetical protein TcasGA2_TC003648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D0I4 179 5.6e-12 Syntaxin-17 OS=Mus musculus GN=Stx17 PE=1 SV=1 PF04728//PF05531//PF06009//PF05739//PF03462 Lipoprotein leucine-zipper//Nucleopolyhedrovirus P10 protein//Laminin Domain II//SNARE domain//PCRF domain GO:0007155//GO:0006415//GO:0006449 cell adhesion//translational termination//regulation of translational termination GO:0005515//GO:0016149 protein binding//translation release factor activity, codon specific GO:0018444//GO:0005737//GO:0005840//GO:0019028//GO:0019867 translation release factor complex//cytoplasm//ribosome//viral capsid//outer membrane KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.26144 BP_3 31.04 0.43 3775 676472292 XP_009059444.1 402 6.0e-36 hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea]>gi|556101324|gb|ESO89976.1| hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea] -- -- -- -- -- -- -- -- -- Q5MCW4 395 1.6e-36 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF00096//PF02892//PF01527//PF13912//PF04218//PF16622//PF02701//PF13465//PF05443//PF15898 Zinc finger, C2H2 type//BED zinc finger//Transposase//C2H2-type zinc finger//CENP-B N-terminal DNA-binding domain//zinc-finger C2H2-type//Dof domain, zinc finger//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//cGMP-dependent protein kinase interacting domain GO:0006355//GO:0006313 regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0008270//GO:0019901//GO:0003677//GO:0046872//GO:0004803 zinc ion binding//protein kinase binding//DNA binding//metal ion binding//transposase activity -- -- -- -- Cluster-8309.26146 BP_3 238.00 15.69 1023 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26149 BP_3 76.96 1.30 3142 270003908 EFA00356.1 178 4.7e-10 hypothetical protein TcasGA2_TC003198 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54HA4 138 8.4e-07 GATA zinc finger domain-containing protein 15 (Fragment) OS=Dictyostelium discoideum GN=gtaO PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2615 BP_3 32.00 2.82 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26150 BP_3 104.24 1.91 2920 91075962 XP_969092.1 1413 2.7e-153 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1185 3.0e-128 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF09177//PF04851//PF07517//PF00270 Syntaxin 6, N-terminal//Type III restriction enzyme, res subunit//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.26151 BP_3 20.22 0.52 2172 91075962 XP_969092.1 1385 3.5e-150 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1157 4.0e-125 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF07517//PF10473//PF09177//PF04851//PF00270 SecA DEAD-like domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0042803//GO:0003676//GO:0045502//GO:0008134//GO:0005524//GO:0003677//GO:0016787 protein homodimerization activity//nucleic acid binding//dynein binding//transcription factor binding//ATP binding//DNA binding//hydrolase activity GO:0016020//GO:0005667//GO:0030286 membrane//transcription factor complex//dynein complex KOG0351 ATP-dependent DNA helicase Cluster-8309.26152 BP_3 8.42 0.75 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26153 BP_3 100.20 1.79 2987 242022338 XP_002431597.1 899 1.1e-93 ATP-dependent DNA helicase Q1, putative [Pediculus humanus corporis]>gi|212516905|gb|EEB18859.1| ATP-dependent DNA helicase Q1, putative [Pediculus humanus corporis] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 Q6AYJ1 798 2.3e-83 ATP-dependent DNA helicase Q1 OS=Rattus norvegicus GN=Recql PE=2 SV=1 PF04851//PF10473//PF09177//PF07517//PF00270 Type III restriction enzyme, res subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0008134//GO:0045502//GO:0016787//GO:0003677//GO:0005524//GO:0003676//GO:0042803 transcription factor binding//dynein binding//hydrolase activity//DNA binding//ATP binding//nucleic acid binding//protein homodimerization activity GO:0005667//GO:0030286//GO:0016020 transcription factor complex//dynein complex//membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.26154 BP_3 102.04 2.45 2298 91075962 XP_969092.1 1413 2.1e-153 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1185 2.4e-128 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF04851//PF09177//PF07517//PF00270 Type III restriction enzyme, res subunit//Syntaxin 6, N-terminal//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.26155 BP_3 17.99 1.65 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26156 BP_3 953.23 37.13 1529 646700412 KDR10573.1 1620 1.4e-177 Adenylosuccinate synthetase [Zootermopsis nevadensis] -- -- -- -- -- K01939 purA, ADSS adenylosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01939 Q17G75 1578 4.3e-174 Adenylosuccinate synthetase OS=Aedes aegypti GN=AAEL003161 PE=3 SV=1 PF01640//PF00709 Peptidase C10 family//Adenylosuccinate synthetase GO:0006508//GO:0006522//GO:0006164//GO:0006531//GO:0006144 proteolysis//alanine metabolic process//purine nucleotide biosynthetic process//aspartate metabolic process//purine nucleobase metabolic process GO:0004019//GO:0005525//GO:0008234 adenylosuccinate synthase activity//GTP binding//cysteine-type peptidase activity -- -- KOG1355 Adenylosuccinate synthase Cluster-8309.26158 BP_3 267.54 13.73 1231 91090510 XP_969573.1 1112 9.1e-119 PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum]>gi|642935364|ref|XP_008197982.1| PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q8IYP9 225 2.7e-17 Palmitoyltransferase ZDHHC23 OS=Homo sapiens GN=ZDHHC23 PE=1 SV=3 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.2616 BP_3 16.00 7.16 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26160 BP_3 32.00 0.72 2444 270015620 EFA12068.1 149 8.4e-07 hypothetical protein TcasGA2_TC005201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26161 BP_3 88.24 0.67 6662 91077990 XP_968879.1 2384 1.6e-265 PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp3 [Tribolium castaneum]>gi|270001423|gb|EEZ97870.1| hypothetical protein TcasGA2_TC000245 [Tribolium castaneum] 642914786 XM_008192130.1 262 6.87269e-132 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X7, mRNA K12843 PRPF3, PRP3 U4/U6 small nuclear ribonucleoprotein PRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K12843 Q922U1 1295 1.2e-140 U4/U6 small nuclear ribonucleoprotein Prp3 OS=Mus musculus GN=Prpf3 PE=2 SV=1 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2769 Putative u4/u6 small nuclear ribonucleoprotein Cluster-8309.26164 BP_3 21.00 0.92 1395 646717332 KDR20226.1 380 7.8e-34 hypothetical protein L798_05535, partial [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 370 4.6e-34 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF06467//PF05495//PF02176//PF00096//PF16622//PF00412//PF02892//PF13912//PF13465 MYM-type Zinc finger with FCS sequence motif//CHY zinc finger//TRAF-type zinc finger//Zinc finger, C2H2 type//zinc-finger C2H2-type//LIM domain//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.26165 BP_3 130.62 20.55 598 91093076 XP_968784.1 693 1.7e-70 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 584 3.1e-59 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26168 BP_3 542.82 13.94 2169 642910961 XP_008193484.1 1080 8.2e-115 PREDICTED: leukocyte elastase inhibitor-like [Tribolium castaneum]>gi|642910963|ref|XP_008193485.1| PREDICTED: leukocyte elastase inhibitor-like [Tribolium castaneum]>gi|642910965|ref|XP_008193486.1| PREDICTED: leukocyte elastase inhibitor-like [Tribolium castaneum]>gi|270015161|gb|EFA11609.1| serpin peptidase inhibitor 30 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TMP0 477 2.8e-46 Uncharacterized serpin-like protein MA_2613/MA_2612 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=MA_2613/MA_2612 PE=3 SV=2 PF05188 MutS domain II GO:0006298 mismatch repair GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- -- -- Cluster-8309.26170 BP_3 12.61 0.37 1955 478263594 ENN81908.1 1943 6.3e-215 hypothetical protein YQE_01712, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- D2XV59 1577 7.2e-174 GTP-binding protein 1 OS=Rattus norvegicus GN=Gtpbp1 PE=1 SV=1 PF10662//PF01926//PF03193//PF03144//PF00005 Ethanolamine utilisation - propanediol utilisation//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Elongation factor Tu domain 2//ABC transporter GO:0006576 cellular biogenic amine metabolic process GO:0003924//GO:0016887//GO:0005525//GO:0005524 GTPase activity//ATPase activity//GTP binding//ATP binding -- -- KOG1143 Predicted translation elongation factor Cluster-8309.26171 BP_3 40.47 2.69 1017 -- -- -- -- -- 820855726 XM_012489619.1 67 2.56334e-24 PREDICTED: Apis florea hepatic leukemia factor (LOC100863581), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26172 BP_3 11.01 0.60 1184 546672449 ERL84307.1 336 8.4e-29 hypothetical protein D910_01716 [Dendroctonus ponderosae] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 137 4.1e-07 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26173 BP_3 1104.39 24.70 2447 478263594 ENN81908.1 2296 9.2e-256 hypothetical protein YQE_01712, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- D2XV59 1841 2.2e-204 GTP-binding protein 1 OS=Rattus norvegicus GN=Gtpbp1 PE=1 SV=1 PF00005//PF03144//PF01926//PF10662 ABC transporter//Elongation factor Tu domain 2//50S ribosome-binding GTPase//Ethanolamine utilisation - propanediol utilisation GO:0006576 cellular biogenic amine metabolic process GO:0005525//GO:0005524//GO:0016887 GTP binding//ATP binding//ATPase activity -- -- KOG1143 Predicted translation elongation factor Cluster-8309.26174 BP_3 465.34 7.08 3460 478250812 ENN71304.1 2971 0.0e+00 hypothetical protein YQE_12229, partial [Dendroctonus ponderosae] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 1638 1.1e-180 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 PF07648//PF00050//PF00093//PF05375 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) -- -- GO:0005515//GO:0030414 protein binding//peptidase inhibitor activity -- -- -- -- Cluster-8309.26175 BP_3 498.64 6.74 3856 642931832 XP_008196749.1 1219 1.1e-130 PREDICTED: GPI inositol-deacylase [Tribolium castaneum]>gi|270011727|gb|EFA08175.1| hypothetical protein TcasGA2_TC005802 [Tribolium castaneum] -- -- -- -- -- K05294 PGAP1 glycosylphosphatidylinositol deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K05294 Q75T13 633 4.1e-64 GPI inositol-deacylase OS=Homo sapiens GN=PGAP1 PE=1 SV=1 PF07819//PF07859//PF07074//PF01764 PGAP1-like protein//alpha/beta hydrolase fold//Translocon-associated protein, gamma subunit (TRAP-gamma)//Lipase (class 3) GO:0009987//GO:0006505//GO:0008152//GO:0006613//GO:0006886//GO:0006629 cellular process//GPI anchor metabolic process//metabolic process//cotranslational protein targeting to membrane//intracellular protein transport//lipid metabolic process GO:0016787//GO:0016788 hydrolase activity//hydrolase activity, acting on ester bonds GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex KOG3724 Negative regulator of COPII vesicle formation Cluster-8309.26179 BP_3 21.26 0.71 1731 801399331 XP_012060168.1 186 3.0e-11 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26180 BP_3 133.06 4.69 1660 642930894 XP_008196130.1 351 2.1e-30 PREDICTED: protein phosphatase inhibitor 2-like [Tribolium castaneum]>gi|270011942|gb|EFA08390.1| hypothetical protein TcasGA2_TC006037 [Tribolium castaneum] -- -- -- -- -- K16833 PPP1R2, IPP2 protein phosphatase inhibitor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16833 P11845 205 7.5e-15 Protein phosphatase inhibitor 2 OS=Oryctolagus cuniculus GN=PPP1R2 PE=1 SV=3 PF04979//PF04272 Protein phosphatase inhibitor 2 (IPP-2)//Phospholamban GO:0009966//GO:0006816//GO:0050794//GO:0006810//GO:0043666 regulation of signal transduction//calcium ion transport//regulation of cellular process//transport//regulation of phosphoprotein phosphatase activity GO:0004864//GO:0005246//GO:0042030 protein phosphatase inhibitor activity//calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane KOG4041 Protein phosphatase 1, regulatory (inhibitor) subunit PPP1R2 Cluster-8309.26181 BP_3 3.00 1.30 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26182 BP_3 71.94 0.87 4300 270003696 EFA00144.1 1416 1.8e-153 hypothetical protein TcasGA2_TC002965 [Tribolium castaneum] 746862194 XM_011063702.1 155 1.33927e-72 PREDICTED: Acromyrmex echinatior uncharacterized LOC105150543 (LOC105150543), mRNA K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q8VHQ2 432 9.3e-41 Suppressor of cytokine signaling 7 OS=Mus musculus GN=Socs7 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.26186 BP_3 361.00 26.04 960 189234193 XP_970277.2 759 6.1e-78 PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [Tribolium castaneum]>gi|270002697|gb|EEZ99144.1| hypothetical protein TcasGA2_TC012925 [Tribolium castaneum] -- -- -- -- -- K08967 mtnD, mtnZ, ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K08967 E0W481 669 6.8e-69 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Pediculus humanus subsp. corporis GN=Phum_PHUM616140 PE=3 SV=1 PF02311//PF00190//PF03079 AraC-like ligand binding domain//Cupin//ARD/ARD' family GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity GO:0005634 nucleus KOG2107 Uncharacterized conserved protein, contains double-stranded beta-helix domain Cluster-8309.26187 BP_3 2.00 0.47 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26188 BP_3 13.62 0.65 1306 642932344 XP_008197074.1 164 8.2e-09 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26190 BP_3 1658.97 51.45 1846 189240395 XP_967842.2 1994 7.3e-221 PREDICTED: lissencephaly-1 homolog [Tribolium castaneum] 195056833 XM_001995131.1 111 1.63896e-48 Drosophila grimshawi GH22777 (Dgri\GH22777), mRNA K16794 PAFAH1B1, LIS1 platelet-activating factor acetylhydrolase IB subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16794 Q7KNS3 1842 1.3e-204 Lissencephaly-1 homolog OS=Drosophila melanogaster GN=Lis-1 PE=1 SV=2 PF08513//PF00400//PF04508 LisH//WD domain, G-beta repeat//Viral A-type inclusion protein repeat GO:0016032 viral process GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.26191 BP_3 350.18 5.39 3426 642927012 XP_008195103.1 743 1.6e-75 PREDICTED: RNA polymerase II-associated protein 3 [Tribolium castaneum]>gi|270010040|gb|EFA06488.1| hypothetical protein TcasGA2_TC009385 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6T3 334 1.7e-29 RNA polymerase II-associated protein 3 OS=Homo sapiens GN=RPAP3 PE=1 SV=2 PF13174//PF13181//PF00435//PF05363//PF13176//PF13414//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Spectrin repeat//Herpesvirus US12 family//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019049 evasion or tolerance of host defenses by virus GO:0005515 protein binding -- -- KOG4648 Uncharacterized conserved protein, contains LRR repeats Cluster-8309.26193 BP_3 1.00 0.68 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26195 BP_3 427.00 20.23 1309 189234542 XP_973179.2 994 4.7e-105 PREDICTED: ubiquitin-like protein 7 [Tribolium castaneum]>gi|270001695|gb|EEZ98142.1| hypothetical protein TcasGA2_TC000567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S82 190 3.3e-13 Ubiquitin-like protein 7 OS=Homo sapiens GN=UBL7 PE=1 SV=2 PF00240//PF14560//PF00920 Ubiquitin family//Ubiquitin-like domain//Dehydratase family GO:0008152 metabolic process GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG0010 Ubiquitin-like protein Cluster-8309.26196 BP_3 96.08 2.06 2539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854 P-11 zinc finger -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.26197 BP_3 2488.00 85.21 1699 91095077 XP_972905.1 1653 2.3e-181 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [Tribolium castaneum]>gi|270014775|gb|EFA11223.1| hypothetical protein TcasGA2_TC005188 [Tribolium castaneum] -- -- -- -- -- K12666 OST1, RPN1 oligosaccharyltransferase complex subunit alpha (ribophorin I) http://www.genome.jp/dbget-bin/www_bget?ko:K12666 Q9GMB0 1030 1.7e-110 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Sus scrofa GN=RPN1 PE=1 SV=1 PF04597 Ribophorin I GO:0018279//GO:0006486 protein N-linked glycosylation via asparagine//protein glycosylation GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0005783//GO:0008250//GO:0016021 endoplasmic reticulum//oligosaccharyltransferase complex//integral component of membrane KOG2291 Oligosaccharyltransferase, alpha subunit (ribophorin I) Cluster-8309.262 BP_3 4.41 1.27 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2620 BP_3 971.00 82.50 859 91095123 XP_970890.1 690 5.5e-70 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 501 1.8e-49 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01073//PF01370//PF12242 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008152//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//metabolic process//estrogen metabolic process GO:0003824//GO:0050662//GO:0003854//GO:0016616//GO:0016491 catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- -- -- Cluster-8309.26200 BP_3 4.09 0.31 931 91078698 XP_971450.1 646 7.5e-65 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q5ZKN1 538 1.0e-53 Cyclin-dependent kinase 9 OS=Gallus gallus GN=CDK9 PE=2 SV=1 -- -- GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004674 ATP binding//protein serine/threonine kinase activity -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.26202 BP_3 475.65 16.42 1688 478258657 ENN78707.1 927 3.5e-97 hypothetical protein YQE_04879, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26203 BP_3 56.44 0.55 5244 357625687 EHJ76049.1 1321 2.3e-142 dimethyladenosine transferase [Danaus plexippus] 505801989 XM_004608470.1 131 3.59126e-59 PREDICTED: Sorex araneus DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) (DIMT1), mRNA K14191 DIM1 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14191 Q9VAQ5 1179 2.7e-127 Probable dimethyladenosine transferase OS=Drosophila melanogaster GN=CG11837 PE=2 SV=1 PF05401//PF01209//PF05958//PF09445//PF08123//PF05175//PF01135//PF08241//PF02390 Nodulation protein S (NodS)//ubiE/COQ5 methyltransferase family//tRNA (Uracil-5-)-methyltransferase//RNA cap guanine-N2 methyltransferase//Histone methylation protein DOT1//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase domain//Putative methyltransferase GO:0009451//GO:0006479//GO:0009877//GO:0046500//GO:0006400//GO:0001510//GO:0009452//GO:0008152//GO:0006554//GO:0006396//GO:0008033//GO:0009312//GO:0006464 RNA modification//protein methylation//nodulation//S-adenosylmethionine metabolic process//tRNA modification//RNA methylation//7-methylguanosine RNA capping//metabolic process//lysine catabolic process//RNA processing//tRNA processing//oligosaccharide biosynthetic process//cellular protein modification process GO:0004719//GO:0008176//GO:0008757//GO:0018024//GO:0008173//GO:0008168 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//histone-lysine N-methyltransferase activity//RNA methyltransferase activity//methyltransferase activity -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.26205 BP_3 15.19 0.44 1940 478258657 ENN78707.1 889 1.0e-92 hypothetical protein YQE_04879, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26207 BP_3 20.11 2.36 703 189239148 XP_001807448.1 460 2.1e-43 PREDICTED: protein doublesex [Tribolium castaneum]>gi|402535157|gb|AFQ62105.1| male-specific doublesex isoform m [Tribolium castaneum] 642928399 XR_511419.1 167 4.4873e-80 PREDICTED: Tribolium castaneum male-specific doublesex isoform m (LOC660453), transcript variant X2, misc_RNA K19488 DMRT1 doublesex- and mab-3-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19488 P23023 260 1.3e-21 Protein doublesex OS=Drosophila melanogaster GN=dsx PE=1 SV=1 PF00751 DM DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- KOG3815 Transcription factor Doublesex Cluster-8309.2621 BP_3 36.90 1.55 1436 546672298 ERL84225.1 288 3.8e-23 hypothetical protein D910_01603 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P26967 234 2.8e-18 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26212 BP_3 55.00 1.54 2016 91080721 XP_975378.1 1456 1.9e-158 PREDICTED: lipase 3 [Tribolium castaneum]>gi|270005867|gb|EFA02315.1| hypothetical protein TcasGA2_TC007981 [Tribolium castaneum] -- -- -- -- -- K14452 LIPF gastric triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14452 P80035 701 2.8e-72 Gastric triacylglycerol lipase OS=Canis familiaris GN=LIPF PE=1 SV=2 PF04083//PF07850//PF01738 Partial alpha/beta-hydrolase lipase region//Renin receptor-like protein//Dienelactone hydrolase family GO:0006629//GO:0016042//GO:0007165 lipid metabolic process//lipid catabolic process//signal transduction GO:0004872//GO:0016787//GO:0016788 receptor activity//hydrolase activity//hydrolase activity, acting on ester bonds GO:0016021 integral component of membrane KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.26213 BP_3 147.02 1.64 4616 478250628 ENN71120.1 3290 0.0e+00 hypothetical protein YQE_12053, partial [Dendroctonus ponderosae]>gi|546679527|gb|ERL89982.1| hypothetical protein D910_07341 [Dendroctonus ponderosae] 542217355 XM_003439025.2 116 6.88487e-51 PREDICTED: Oreochromis niloticus pre-mRNA-processing factor 6-like (LOC100696507), mRNA K12855 PRPF6, PRP6 pre-mRNA-processing factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12855 O94906 2718 8.3e-306 Pre-mRNA-processing factor 6 OS=Homo sapiens GN=PRPF6 PE=1 SV=1 PF13414//PF01267//PF01115//PF02915//PF13371//PF00515//PF02259//PF05843//PF02099//PF06424//PF13181 TPR repeat//F-actin capping protein alpha subunit//F-actin capping protein, beta subunit//Rubrerythrin//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Suppressor of forked protein (Suf)//Josephin//PRP1 splicing factor, N-terminal//Tetratricopeptide repeat GO:0006397//GO:0051016//GO:0000398//GO:0055114 mRNA processing//barbed-end actin filament capping//mRNA splicing, via spliceosome//oxidation-reduction process GO:0008242//GO:0016491//GO:0005515//GO:0046872 omega peptidase activity//oxidoreductase activity//protein binding//metal ion binding GO:0005634//GO:0008290 nucleus//F-actin capping protein complex KOG0495 HAT repeat protein Cluster-8309.26214 BP_3 7.00 11.81 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26216 BP_3 1318.91 22.77 3083 642920970 XP_974457.2 2338 1.6e-260 PREDICTED: serine palmitoyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K00654 SPT serine palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00654 P97363 1348 4.0e-147 Serine palmitoyltransferase 2 OS=Mus musculus GN=Sptlc2 PE=2 SV=2 PF01212//PF04805//PF00155 Beta-eliminating lyase//E10-like protein conserved region//Aminotransferase class I and II GO:0055114//GO:0006520//GO:0009058 oxidation-reduction process//cellular amino acid metabolic process//biosynthetic process GO:0030170//GO:0016972//GO:0016829 pyridoxal phosphate binding//thiol oxidase activity//lyase activity -- -- KOG1357 Serine palmitoyltransferase Cluster-8309.26219 BP_3 735.09 18.07 2253 642910317 XP_008200281.1 1312 1.1e-141 PREDICTED: dimethyladenosine transferase 1, mitochondrial [Tribolium castaneum] -- -- -- -- -- K15266 TFB1M dimethyladenosine transferase 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K15266 Q7T0W5 857 2.5e-90 Dimethyladenosine transferase 1, mitochondrial OS=Xenopus laevis GN=tfb1m PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.26220 BP_3 108.96 2.52 2374 642933337 XP_008197372.1 841 4.7e-87 PREDICTED: E3 ubiquitin-protein ligase SIAH1-like [Tribolium castaneum]>gi|270012581|gb|EFA09029.1| hypothetical protein TcasGA2_TC006740 [Tribolium castaneum] 807039743 XM_004534931.2 43 1.33867e-10 PREDICTED: Ceratitis capitata INO80 complex subunit E (In80e), mRNA K11669 INO80E INO80 complex subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K11669 P61092 293 6.7e-25 E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a PE=1 SV=1 PF13639//PF00097//PF03145//PF09726//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//Transmembrane protein//zinc-RING finger domain GO:0044267//GO:0006511//GO:0007275 cellular protein metabolic process//ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0046872//GO:0043169//GO:0008270//GO:0005515 metal ion binding//cation binding//zinc ion binding//protein binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3002 Zn finger protein Cluster-8309.26223 BP_3 5.00 1.07 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26224 BP_3 87.48 1.60 2919 642931178 XP_001810533.2 1458 1.6e-158 PREDICTED: general transcription factor 3C polypeptide 3 [Tribolium castaneum]>gi|270011861|gb|EFA08309.1| hypothetical protein TcasGA2_TC005945 [Tribolium castaneum] -- -- -- -- -- K15201 GTP3C3, TFC4 general transcription factor 3C polypeptide 3 (transcription factor C subunit 4) http://www.genome.jp/dbget-bin/www_bget?ko:K15201 Q9Y5Q9 580 4.3e-58 General transcription factor 3C polypeptide 3 OS=Homo sapiens GN=GTF3C3 PE=1 SV=1 PF08631//PF13181//PF13174//PF16045//PF13374//PF00515//PF13371//PF13414//PF13176 Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat//LisH//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0051321 meiotic cell cycle GO:0005515 protein binding -- -- KOG2076 RNA polymerase III transcription factor TFIIIC Cluster-8309.26225 BP_3 3.00 0.51 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26226 BP_3 23.27 0.84 1620 91077766 XP_968426.1 1023 2.5e-108 PREDICTED: WD repeat domain phosphoinositide-interacting protein 4 [Tribolium castaneum]>gi|270002238|gb|EEZ98685.1| hypothetical protein TcasGA2_TC001220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCV0 778 2.6e-81 WD repeat domain phosphoinositide-interacting protein 4 OS=Xenopus laevis GN=wdr45 PE=2 SV=1 PF08053 Tryptophanase operon leader peptide GO:0031556//GO:0031554 transcriptional attenuation by ribosome//regulation of DNA-templated transcription, termination -- -- -- -- KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.26227 BP_3 42.95 1.95 1354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26228 BP_3 74.47 2.71 1616 291170322 ADD82417.1 229 2.9e-16 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 117 6.61e-52 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26231 BP_3 549.97 25.43 1334 642913025 XP_008201356.1 142 3.0e-06 PREDICTED: RING finger protein 165-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130//PF11789//PF17122//PF00097//PF12678//PF12906//PF17123//PF14634//PF13639//PF03854//PF12861 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger of the MIZ type in Nse subunit//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-variant domain//RING-like zinc finger//zinc-RING finger domain//Ring finger domain//P-11 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0035556//GO:0016567 intracellular signal transduction//protein ubiquitination GO:0046872//GO:0008270//GO:0004842//GO:0005515//GO:0003723 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding//RNA binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.26232 BP_3 44.03 1.94 1384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26233 BP_3 8.00 0.50 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26234 BP_3 40.00 5.14 667 328899820 AEB54650.1 916 2.6e-96 ribosomal protein S7 [Procambarus clarkii] -- -- -- -- -- K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 P62083 684 8.6e-71 40S ribosomal protein S7 OS=Rattus norvegicus GN=Rps7 PE=1 SV=1 PF02882//PF01251 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Ribosomal protein S7e GO:0055114//GO:0042254//GO:0006412//GO:0046487//GO:0009396 oxidation-reduction process//ribosome biogenesis//translation//glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0003735//GO:0004488//GO:0003824 structural constituent of ribosome//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG3320 40S ribosomal protein S7 Cluster-8309.26235 BP_3 1.00 23.78 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26236 BP_3 3.00 0.53 565 645020639 XP_008207241.1 171 5.4e-10 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26237 BP_3 209.00 1369.54 255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26238 BP_3 113435.33 5583.28 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26239 BP_3 11.67 1.17 772 642935715 XP_008198140.1 269 3.2e-21 PREDICTED: beclin 1-associated autophagy-related key regulator [Tribolium castaneum] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26240 BP_3 3.77 0.51 647 546685745 ERL95200.1 303 3.1e-25 hypothetical protein D910_12468 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26241 BP_3 7.49 0.70 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26242 BP_3 33.04 0.93 2008 642919747 XP_008192048.1 1894 3.1e-209 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 825 1.2e-86 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 PF02822 Antistasin family -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG3620 Uncharacterized conserved protein Cluster-8309.26244 BP_3 269.00 4.30 3308 478253220 ENN73591.1 1325 4.9e-143 hypothetical protein YQE_09838, partial [Dendroctonus ponderosae]>gi|546671454|gb|ERL83761.1| hypothetical protein D910_00981 [Dendroctonus ponderosae]>gi|546674153|gb|ERL85609.1| hypothetical protein D910_03028 [Dendroctonus ponderosae]>gi|546685850|gb|ERL95285.1| hypothetical protein D910_12551 [Dendroctonus ponderosae] -- -- -- -- -- K15281 SLC35D solute carrier family 35 http://www.genome.jp/dbget-bin/www_bget?ko:K15281 Q95YI5 1107 3.8e-119 UDP-sugar transporter UST74c OS=Drosophila melanogaster GN=frc PE=1 SV=2 PF09472 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) GO:0015948//GO:0046656 methanogenesis//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane KOG1444 Nucleotide-sugar transporter VRG4/SQV-7 Cluster-8309.26246 BP_3 278.00 3.66 3950 642916131 XP_008190899.1 1951 1.5e-215 PREDICTED: RNA exonuclease 1 homolog [Tribolium castaneum]>gi|270003711|gb|EFA00159.1| hypothetical protein TcasGA2_TC002980 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q8N1G1 794 9.0e-83 RNA exonuclease 1 homolog OS=Homo sapiens GN=REXO1 PE=1 SV=3 PF03854//PF05656 P-11 zinc finger//Protein of unknown function (DUF805) -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding GO:0016021 integral component of membrane KOG2248 3'-5' exonuclease Cluster-8309.26247 BP_3 193.86 1.44 6771 820805554 AKG92768.1 605 3.1e-59 cropped [Leptinotarsa decemlineata] 462279222 APGK01058391.1 41 4.98238e-09 Dendroctonus ponderosae Seq01058401, whole genome shotgun sequence K09108 TFAP4 transcription factor AP-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09108 Q01664 164 1.7e-09 Transcription factor AP-4 OS=Homo sapiens GN=TFAP4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26248 BP_3 89.91 1.79 2710 642919713 XP_008192033.1 1789 6.3e-197 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.4e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.2625 BP_3 16.03 0.35 2493 270001382 EEZ97829.1 1601 3.7e-175 hypothetical protein TcasGA2_TC000197 [Tribolium castaneum] -- -- -- -- -- K01217 IDUA L-iduronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01217 P48441 897 6.5e-95 Alpha-L-iduronidase OS=Mus musculus GN=Idua PE=1 SV=2 PF01229 Glycosyl hydrolases family 39 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.26251 BP_3 108.00 1.65 3456 189235376 XP_968738.2 1786 1.8e-196 PREDICTED: neutral alpha-glucosidase AB isoform X2 [Tribolium castaneum]>gi|270003604|gb|EFA00052.1| hypothetical protein TcasGA2_TC002860 [Tribolium castaneum] 745752852 XM_002174403.2 36 1.52339e-06 Schizosaccharomyces japonicus yFS275 glucosidase II Gls2 mRNA K12317 GANC neutral alpha-glucosidase C http://www.genome.jp/dbget-bin/www_bget?ko:K12317 Q8BVW0 1574 2.8e-173 Neutral alpha-glucosidase C OS=Mus musculus GN=Ganc PE=2 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.26253 BP_3 520.74 6.53 4135 478251184 ENN71660.1 1199 2.5e-128 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K14410 ACP2 lysosomal acid phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14410 P11117 621 1.1e-62 Lysosomal acid phosphatase OS=Homo sapiens GN=ACP2 PE=1 SV=3 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.26256 BP_3 175.57 8.75 1259 91083895 XP_974479.1 951 4.3e-100 PREDICTED: ATPase family AAA domain-containing protein 3 [Tribolium castaneum]>gi|270007948|gb|EFA04396.1| hypothetical protein TcasGA2_TC014695 [Tribolium castaneum] -- -- -- -- -- K17681 ATAD3A_B ATPase family AAA domain-containing protein 3A/B http://www.genome.jp/dbget-bin/www_bget?ko:K17681 Q6PAX2 653 6.4e-67 ATPase family AAA domain-containing protein 3-B OS=Xenopus laevis GN=atad3-b PE=2 SV=1 -- -- -- -- GO:0005524//GO:0017111 ATP binding//nucleoside-triphosphatase activity -- -- KOG0742 AAA+-type ATPase Cluster-8309.26257 BP_3 76.02 1.02 3885 642922614 XP_008193249.1 1384 8.3e-150 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26258 BP_3 41.97 0.64 3462 642922614 XP_008193249.1 1447 3.7e-157 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26259 BP_3 34.87 0.65 2884 642922614 XP_008193249.1 884 5.8e-92 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26261 BP_3 42.45 0.69 3247 642922614 XP_008193249.1 1387 3.1e-150 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26262 BP_3 11.00 0.64 1121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26264 BP_3 57.00 1.82 1799 270005507 EFA01955.1 223 1.6e-15 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 193 2.0e-13 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 PF02798 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26265 BP_3 7.00 1.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26266 BP_3 858.52 27.04 1822 91080137 XP_968355.1 2213 2.9e-246 PREDICTED: T-complex protein 1 subunit epsilon [Tribolium castaneum]>gi|270005652|gb|EFA02100.1| hypothetical protein TcasGA2_TC007744 [Tribolium castaneum] 769836104 XM_011649878.1 157 4.34027e-74 PREDICTED: Pogonomyrmex barbatus T-complex protein 1 subunit epsilon (LOC105434223), mRNA K09497 CCT5 T-complex protein 1 subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09497 Q4R6V2 1803 4.1e-200 T-complex protein 1 subunit epsilon OS=Macaca fascicularis GN=CCT5 PE=2 SV=1 PF07546//PF00118 EMI domain//TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005515//GO:0051082//GO:0005524 protein binding//unfolded protein binding//ATP binding GO:0005737 cytoplasm KOG0357 Chaperonin complex component, TCP-1 epsilon subunit (CCT5) Cluster-8309.26267 BP_3 18.43 0.73 1511 642936522 XP_008198471.1 686 2.8e-69 PREDICTED: BRCA1-A complex subunit BRE-like [Tribolium castaneum]>gi|270014127|gb|EFA10575.1| hypothetical protein TcasGA2_TC012831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6SP92 341 1.2e-30 BRCA1-A complex subunit BRE OS=Mesocricetus auratus GN=Bre PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26270 BP_3 7.07 0.96 646 270004092 EFA00540.1 407 2.7e-37 hypothetical protein TcasGA2_TC003405 [Tribolium castaneum] 827544782 XM_012689556.1 56 2.07908e-18 PREDICTED: Bombyx mori inorganic phosphate co-transporter (LOC100500932), transcript variant X2, mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 326 2.7e-29 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26271 BP_3 913.24 14.12 3410 642929686 XP_008195936.1 1180 3.3e-126 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] 462360465 APGK01029384.1 79 1.87656e-30 Dendroctonus ponderosae Seq01029394, whole genome shotgun sequence K06064 HAIRLESS hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06064 Q02308 257 1.4e-20 Protein hairless OS=Drosophila melanogaster GN=H PE=1 SV=2 PF07706 Aminotransferase ubiquitination site GO:0006536//GO:0009821//GO:0009074//GO:0006571//GO:0000162//GO:0006103//GO:0009094 glutamate metabolic process//alkaloid biosynthetic process//aromatic amino acid family catabolic process//tyrosine biosynthetic process//tryptophan biosynthetic process//2-oxoglutarate metabolic process//L-phenylalanine biosynthetic process GO:0030170//GO:0004838 pyridoxal phosphate binding//L-tyrosine:2-oxoglutarate aminotransferase activity -- -- -- -- Cluster-8309.26274 BP_3 138.57 1.00 6960 642921466 XP_008192880.1 4105 0.0e+00 PREDICTED: transient receptor potential-gamma protein [Tribolium castaneum] 194884299 XM_001976197.1 386 0 Drosophila erecta GG20120 (Dere\GG20120), mRNA K05328 TRPCN transient receptor potential cation channel subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05328 Q9VJJ7 3423 0.0e+00 Transient receptor potential-gamma protein OS=Drosophila melanogaster GN=Trpgamma PE=1 SV=2 PF00520//PF04692//PF09726//PF13606 Ion transport protein//Platelet-derived growth factor, N terminal region//Transmembrane protein//Ankyrin repeat GO:0008283//GO:0040007//GO:0007165//GO:0055085//GO:0006811 cell proliferation//growth//signal transduction//transmembrane transport//ion transport GO:0005515//GO:0008083//GO:0005216 protein binding//growth factor activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3609 Receptor-activated Ca2+-permeable cation channels (STRPC family) Cluster-8309.26277 BP_3 1504.50 25.27 3161 91091700 XP_972740.1 3069 0.0e+00 PREDICTED: mannosyl-oligosaccharide glucosidase [Tribolium castaneum]>gi|270001063|gb|EEZ97510.1| hypothetical protein TcasGA2_TC011354 [Tribolium castaneum] -- -- -- -- -- K01228 GCS1 mannosyl-oligosaccharide glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01228 F4HTM3 1598 4.2e-176 Mannosyl-oligosaccharide glucosidase GCS1 OS=Arabidopsis thaliana GN=GCS1 PE=1 SV=1 -- -- GO:0009311 oligosaccharide metabolic process GO:0004573 mannosyl-oligosaccharide glucosidase activity -- -- KOG2161 Glucosidase I Cluster-8309.2628 BP_3 12.84 0.33 2182 157128008 XP_001661271.1 980 3.3e-103 AAEL010985-PA [Aedes aegypti]>gi|108872753|gb|EAT36978.1| AAEL010985-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03523 Macrophage scavenger receptor GO:0007165//GO:0006898 signal transduction//receptor-mediated endocytosis GO:0005044 scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.26280 BP_3 1053.75 10.28 5232 646699278 KDR09984.1 1811 3.4e-199 Ribosomal protein S6 kinase beta-1 [Zootermopsis nevadensis] 645004372 XM_008210703.1 188 7.38108e-91 PREDICTED: Nasonia vitripennis ribosomal protein S6 kinase beta-1-like (LOC100115857), transcript variant X3, mRNA K04688 RPS6KB p70 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04688 P67998 1466 1.4e-160 Ribosomal protein S6 kinase beta-1 OS=Oryctolagus cuniculus GN=RPS6KB1 PE=2 SV=1 PF05180//PF07714//PF00433//PF00069//PF06293 DNL zinc finger//Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0016773//GO:0008270//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//zinc ion binding//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.26282 BP_3 124.20 1.20 5262 665804096 XP_008550173.1 2041 7.4e-226 PREDICTED: potassium voltage-gated channel protein Shab isoform X2 [Microplitis demolitor] 189008483 EU616810.1 323 6.67626e-166 Tribolium castaneum shaker cognate b (Shab) gene, exon 2 and partial cds K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1859 3.8e-206 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF02214//PF00060//PF00520//PF01092//PF13374 BTB/POZ domain//Ligand-gated ion channel//Ion transport protein//Ribosomal protein S6e//Tetratricopeptide repeat GO:0007165//GO:0055085//GO:0051260//GO:0007268//GO:0006412//GO:0042254//GO:0006811 signal transduction//transmembrane transport//protein homooligomerization//synaptic transmission//translation//ribosome biogenesis//ion transport GO:0005515//GO:0004970//GO:0005216//GO:0003735 protein binding//ionotropic glutamate receptor activity//ion channel activity//structural constituent of ribosome GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular -- -- Cluster-8309.26283 BP_3 390.99 11.12 1987 642921348 XP_008192831.1 2198 1.7e-244 PREDICTED: uncharacterized protein LOC658985 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G5E8K6 233 5.1e-18 Monocarboxylate transporter 6 OS=Mus musculus GN=Slc16a5 PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26284 BP_3 193.95 3.47 2987 91077436 XP_966791.1 3598 0.0e+00 PREDICTED: WD repeat-containing protein 36 [Tribolium castaneum]>gi|270001624|gb|EEZ98071.1| hypothetical protein TcasGA2_TC000478 [Tribolium castaneum] -- -- -- -- -- K14554 UTP21, WDR36 U3 small nucleolar RNA-associated protein 21 http://www.genome.jp/dbget-bin/www_bget?ko:K14554 Q8NI36 2029 4.2e-226 WD repeat-containing protein 36 OS=Homo sapiens GN=WDR36 PE=1 SV=1 PF00400//PF04192//PF00355 WD domain, G-beta repeat//Utp21 specific WD40 associated putative domain//Rieske [2Fe-2S] domain GO:0006364//GO:0055114 rRNA processing//oxidation-reduction process GO:0051537//GO:0016491//GO:0005515 2 iron, 2 sulfur cluster binding//oxidoreductase activity//protein binding GO:0032040 small-subunit processome KOG1539 WD repeat protein Cluster-8309.26286 BP_3 258.00 12.02 1326 478253141 ENN73512.1 1034 1.1e-109 hypothetical protein YQE_09763, partial [Dendroctonus ponderosae]>gi|546678893|gb|ERL89431.1| hypothetical protein D910_06798 [Dendroctonus ponderosae] -- -- -- -- -- K11152 RDH11 retinol dehydrogenase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11152 Q8TC12 513 1.2e-50 Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1 SV=2 PF13520//PF02882//PF00106//PF03435//PF01370 Amino acid permease//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//short chain dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family GO:0003333//GO:0055114//GO:0006865//GO:0008152//GO:0009396//GO:0046487 amino acid transmembrane transport//oxidation-reduction process//amino acid transport//metabolic process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process GO:0015171//GO:0003824//GO:0050662//GO:0016491//GO:0004488 amino acid transmembrane transporter activity//catalytic activity//coenzyme binding//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0016020 membrane -- -- Cluster-8309.26289 BP_3 69.42 6.87 779 270001906 EEZ98353.1 159 1.8e-08 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2629 BP_3 3965.93 278.14 979 478254273 ENN74527.1 216 5.7e-15 hypothetical protein YQE_08851, partial [Dendroctonus ponderosae]>gi|546671467|gb|ERL83769.1| hypothetical protein D910_00997 [Dendroctonus ponderosae]>gi|546672146|gb|ERL84147.1| hypothetical protein D910_01508 [Dendroctonus ponderosae]>gi|546674915|gb|ERL86197.1| hypothetical protein D910_03608 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04111//PF02970//PF10174 Autophagy protein Apg6//Tubulin binding cofactor A//RIM-binding protein of the cytomatrix active zone GO:0006914//GO:0007021 autophagy//tubulin complex assembly GO:0015631//GO:0051082 tubulin binding//unfolded protein binding GO:0045298//GO:0048786 tubulin complex//presynaptic active zone -- -- Cluster-8309.26290 BP_3 14.00 13.93 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15307 Sperm acrosome-associated protein 7 -- -- -- -- GO:0001669 acrosomal vesicle -- -- Cluster-8309.26291 BP_3 288.53 2.28 6384 642921412 XP_008192854.1 1114 2.8e-118 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.43765e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 791 3.2e-82 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF05648//PF00937 Peroxisomal biogenesis factor 11 (PEX11)//Coronavirus nucleocapsid protein GO:0016559 peroxisome fission -- -- GO:0005779//GO:0019013 integral component of peroxisomal membrane//viral nucleocapsid -- -- Cluster-8309.26292 BP_3 64.88 3.47 1193 642926579 XP_008194928.1 228 2.8e-16 PREDICTED: transcription factor 15 isoform X1 [Tribolium castaneum] 564234777 XM_006274259.1 76 2.99745e-29 PREDICTED: Alligator mississippiensis transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA K09070 TCF15, PARAXIS transcription factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09070 Q7RTU7 190 3.0e-13 Basic helix-loop-helix transcription factor scleraxis OS=Homo sapiens GN=SCX PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26293 BP_3 811.00 18.97 2352 642927551 XP_008195312.1 585 2.2e-57 PREDICTED: protein HEXIM [Tribolium castaneum]>gi|270009936|gb|EFA06384.1| hypothetical protein TcasGA2_TC009262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0X0C4 192 3.4e-13 Protein HEXIM1 OS=Bos taurus GN=HEXIM1 PE=2 SV=1 PF04799//PF15313//PF01166//PF06156//PF04977//PF06005//PF09798//PF01496 fzo-like conserved region//Hexamethylene bis-acetamide-inducible protein//TSC-22/dip/bun family//Protein of unknown function (DUF972)//Septum formation initiator//Protein of unknown function (DUF904)//DNA damage checkpoint protein//V-type ATPase 116kDa subunit family GO:0015992//GO:0007049//GO:0006355//GO:0006260//GO:0000077//GO:0007050//GO:0045859//GO:0015991//GO:0043093//GO:0000917//GO:0008053//GO:0000122 proton transport//cell cycle//regulation of transcription, DNA-templated//DNA replication//DNA damage checkpoint//cell cycle arrest//regulation of protein kinase activity//ATP hydrolysis coupled proton transport//FtsZ-dependent cytokinesis//barrier septum assembly//mitochondrial fusion//negative regulation of transcription from RNA polymerase II promoter GO:0003924//GO:0003700//GO:0015078//GO:0004861//GO:0017069 GTPase activity//transcription factor activity, sequence-specific DNA binding//hydrogen ion transmembrane transporter activity//cyclin-dependent protein serine/threonine kinase inhibitor activity//snRNA binding GO:0016021//GO:0005737//GO:0005667//GO:0005634//GO:0033179//GO:0005741 integral component of membrane//cytoplasm//transcription factor complex//nucleus//proton-transporting V-type ATPase, V0 domain//mitochondrial outer membrane -- -- Cluster-8309.26295 BP_3 162.00 4.40 2065 642936365 XP_008198409.1 151 4.2e-07 PREDICTED: uncharacterized protein LOC103314354 [Tribolium castaneum]>gi|642936367|ref|XP_008198410.1| PREDICTED: uncharacterized protein LOC103314354 [Tribolium castaneum]>gi|270013126|gb|EFA09574.1| hypothetical protein TcasGA2_TC011688 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26297 BP_3 62.38 0.40 7747 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 9.2e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF07817//PF01926//PF03810//PF08477//PF03193//PF02421//PF00071 GLE1-like protein//50S ribosome-binding GTPase//Importin-beta N-terminal domain//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Ferrous iron transport protein B//Ras family GO:0015684//GO:0015031//GO:0007264//GO:0016973//GO:0006886 ferrous iron transport//protein transport//small GTPase mediated signal transduction//poly(A)+ mRNA export from nucleus//intracellular protein transport GO:0008565//GO:0005525//GO:0015093//GO:0003924//GO:0008536 protein transporter activity//GTP binding//ferrous iron transmembrane transporter activity//GTPase activity//Ran GTPase binding GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.26298 BP_3 1817.57 13.11 6973 642926768 XP_008195006.1 4299 0.0e+00 PREDICTED: copper-transporting ATPase 1 isoform X2 [Tribolium castaneum] 827557043 XM_012694365.1 41 5.13184e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2570 1.8e-288 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF01529//PF00122//PF05138//PF00403 DHHC palmitoyltransferase//E1-E2 ATPase//Phenylacetic acid catabolic protein//Heavy-metal-associated domain GO:0010124//GO:0030001 phenylacetate catabolic process//metal ion transport GO:0046872//GO:0000166//GO:0008270 metal ion binding//nucleotide binding//zinc ion binding -- -- KOG0207 Cation transport ATPase Cluster-8309.26299 BP_3 252.47 3.87 3435 642932705 XP_008196952.1 1577 3.1e-172 PREDICTED: HEAT repeat-containing protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R5R2 919 2.5e-97 HEAT repeat-containing protein 6 OS=Pongo abelii GN=HEATR6 PE=2 SV=1 PF00514//PF01667//PF01106//PF02985 Armadillo/beta-catenin-like repeat//Ribosomal protein S27//NifU-like domain//HEAT repeat GO:0042254//GO:0016226//GO:0006412 ribosome biogenesis//iron-sulfur cluster assembly//translation GO:0051536//GO:0003735//GO:0005506//GO:0005515 iron-sulfur cluster binding//structural constituent of ribosome//iron ion binding//protein binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.26302 BP_3 91.46 0.61 7488 91076790 XP_974060.1 1328 5.0e-143 PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|642913035|ref|XP_008201360.1| PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|270001925|gb|EEZ98372.1| hypothetical protein TcasGA2_TC000831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88879 495 8.0e-48 Apoptotic protease-activating factor 1 OS=Mus musculus GN=Apaf1 PE=1 SV=3 PF00400//PF07569//PF00931 WD domain, G-beta repeat//TUP1-like enhancer of split//NB-ARC domain GO:0006355 regulation of transcription, DNA-templated GO:0043531//GO:0005515 ADP binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.26304 BP_3 4.00 1.37 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08918 PhoQ Sensor GO:0016310//GO:0000160//GO:0018106 phosphorylation//phosphorelay signal transduction system//peptidyl-histidine phosphorylation GO:0005524//GO:0046872//GO:0004673 ATP binding//metal ion binding//protein histidine kinase activity GO:0009365//GO:0016020 protein histidine kinase complex//membrane -- -- Cluster-8309.26306 BP_3 793.70 19.28 2276 642915333 XP_008190576.1 634 4.5e-63 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 473 8.6e-46 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26307 BP_3 10.00 0.33 1735 546681812 ERL91838.1 1796 6.2e-198 hypothetical protein D910_09163 [Dendroctonus ponderosae] -- -- -- -- -- K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1756 1.1e-194 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.26308 BP_3 120.68 2.37 2749 642924494 XP_008194318.1 1947 3.1e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 6.9e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.2631 BP_3 2.00 0.42 522 478252819 ENN73210.1 261 1.8e-20 hypothetical protein YQE_10189, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9IU29 139 1.1e-07 Kynurenine formamidase OS=Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) GN=kynB PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26310 BP_3 115.28 3.56 1854 91088619 XP_974054.1 1761 7.6e-194 PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [Tribolium castaneum]>gi|270011691|gb|EFA08139.1| hypothetical protein TcasGA2_TC005756 [Tribolium castaneum] -- -- -- -- -- K00995 pgsA, PGS1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00995 Q32NB8 953 1.5e-101 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial OS=Homo sapiens GN=PGS1 PE=2 SV=1 PF00614 Phospholipase D Active site motif GO:0008654 phospholipid biosynthetic process GO:0003824//GO:0016780 catalytic activity//phosphotransferase activity, for other substituted phosphate groups -- -- KOG3964 Phosphatidylglycerolphosphate synthase Cluster-8309.26318 BP_3 804.00 12.34 3432 478254021 ENN74313.1 3107 0.0e+00 hypothetical protein YQE_09284, partial [Dendroctonus ponderosae] 642910778 XM_008195184.1 354 0 PREDICTED: Tribolium castaneum membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (LOC657569), mRNA K05629 AIP1 atrophin-1 interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05629 O88382 888 9.8e-94 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Magi2 PE=1 SV=1 PF01165//PF00595//PF07782//PF13180//PF00397 Ribosomal protein S21//PDZ domain (Also known as DHR or GLGF)//DC-STAMP-like protein//PDZ domain//WW domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0016021//GO:0005840 integral component of membrane//ribosome KOG3209 WW domain-containing protein Cluster-8309.26319 BP_3 223.00 5.13 2385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26320 BP_3 130.31 1.62 4175 642937253 XP_008198758.1 2387 4.4e-266 PREDICTED: probable ATP-dependent RNA helicase YTHDC2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6S0 1644 2.6e-181 Probable ATP-dependent RNA helicase YTHDC2 OS=Homo sapiens GN=YTHDC2 PE=1 SV=2 PF04408//PF02562//PF00023//PF01424//PF00437//PF02386//PF00270 Helicase associated domain (HA2)//PhoH-like protein//Ankyrin repeat//R3H domain//Type II/IV secretion system protein//Cation transport protein//DEAD/DEAH box helicase GO:0006810//GO:0055085//GO:0006812 transport//transmembrane transport//cation transport GO:0005515//GO:0005524//GO:0004386//GO:0008324//GO:0003676 protein binding//ATP binding//helicase activity//cation transmembrane transporter activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.26321 BP_3 404.69 3.77 5470 642937251 XP_008198757.1 2387 5.8e-266 PREDICTED: probable ATP-dependent RNA helicase YTHDC2 isoform X1 [Tribolium castaneum]>gi|270001262|gb|EEZ97709.1| benign gonial cell neoplasm [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6S0 1644 3.4e-181 Probable ATP-dependent RNA helicase YTHDC2 OS=Homo sapiens GN=YTHDC2 PE=1 SV=2 PF00437//PF00270//PF02386//PF00023//PF01424//PF02562//PF04408 Type II/IV secretion system protein//DEAD/DEAH box helicase//Cation transport protein//Ankyrin repeat//R3H domain//PhoH-like protein//Helicase associated domain (HA2) GO:0055085//GO:0006810//GO:0006812 transmembrane transport//transport//cation transport GO:0005524//GO:0004386//GO:0016787//GO:0005515//GO:0008324//GO:0097159//GO:0003676//GO:1901363 ATP binding//helicase activity//hydrolase activity//protein binding//cation transmembrane transporter activity//organic cyclic compound binding//nucleic acid binding//heterocyclic compound binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.26324 BP_3 10.21 0.42 1476 91088245 XP_974001.1 235 5.4e-17 PREDICTED: antichymotrypsin-2 [Tribolium castaneum]>gi|270012774|gb|EFA09222.1| serpin peptidase inhibitor 24 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14754 166 2.2e-10 Alaserpin OS=Manduca sexta PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26325 BP_3 125.00 8.80 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26326 BP_3 59.78 0.87 3598 642926591 XP_008194932.1 772 7.1e-79 PREDICTED: scavenger receptor class B member 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60417 222 1.7e-16 Scavenger receptor class B member 1 OS=Cricetulus griseus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane KOG3776 Plasma membrane glycoprotein CD36 and related membrane receptors Cluster-8309.26327 BP_3 66.00 3.71 1150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26329 BP_3 1.00 7.80 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2633 BP_3 21.00 1.84 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26331 BP_3 9.00 0.35 1535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26334 BP_3 247.00 4.06 3225 820805516 AKG92749.1 2092 5.5e-232 clock [Leptinotarsa decemlineata] 805825616 XM_012297303.1 135 1.31414e-61 PREDICTED: Megachile rotundata circadian locomoter output cycles protein kaput (LOC100878984), transcript variant X3, mRNA K02223 CLOCK, KAT13D circadian locomoter output cycles kaput protein http://www.genome.jp/dbget-bin/www_bget?ko:K02223 O61735 1157 5.9e-125 Circadian locomoter output cycles protein kaput OS=Drosophila melanogaster GN=Clk PE=1 SV=3 PF08447//PF00010//PF00989//PF00523 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold//Fusion glycoprotein F0 GO:0006355//GO:0006948 regulation of transcription, DNA-templated//induction by virus of host cell-cell fusion GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.26339 BP_3 640.08 8.56 3894 91081997 XP_969187.1 2758 3.9e-309 PREDICTED: pre-mRNA 3' end processing protein WDR33 [Tribolium castaneum]>gi|270007376|gb|EFA03824.1| hypothetical protein TcasGA2_TC013939 [Tribolium castaneum] 556962117 XM_005991191.1 147 3.39303e-68 PREDICTED: Latimeria chalumnae WD repeat domain 33 (WDR33), mRNA K15542 PFS2 polyadenylation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15542 Q8K4P0 1664 1.2e-183 pre-mRNA 3' end processing protein WDR33 OS=Mus musculus GN=Wdr33 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0284 Polyadenylation factor I complex, subunit PFS2 Cluster-8309.2634 BP_3 4.00 0.67 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26340 BP_3 4.20 0.35 866 817072391 XP_012258295.1 1284 7.3e-139 PREDICTED: tubulin alpha-1 chain-like [Athalia rosae] 195498861 XM_002096671.1 477 0 Drosophila yakuba alphaTub84B (Dyak\alphaTub84B), partial mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P06603 1290 6.0e-141 Tubulin alpha-1 chain OS=Drosophila melanogaster GN=alphaTub84B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1376 Alpha tubulin Cluster-8309.26341 BP_3 65.03 0.83 4076 642931340 XP_008196537.1 1174 1.9e-125 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X2 [Tribolium castaneum] 645002817 XM_008209793.1 196 2.04954e-95 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X2, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 1033 1.8e-110 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.26342 BP_3 95.69 1.33 3752 642931340 XP_008196537.1 2722 5.7e-305 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X2 [Tribolium castaneum] 645002817 XM_008209793.1 317 1.02759e-162 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X2, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 2212 3.2e-247 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.26343 BP_3 29.86 0.81 2061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26344 BP_3 72.92 7.24 777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26345 BP_3 106.35 1.20 4548 642925191 XP_008194463.1 3204 0.0e+00 PREDICTED: myelin regulatory factor isoform X4 [Tribolium castaneum]>gi|270008766|gb|EFA05214.1| hypothetical protein TcasGA2_TC015354 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.20062e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1228 4.9e-133 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF05224//PF10152 NDT80 / PhoG like DNA-binding family//Predicted coiled-coil domain-containing protein (DUF2360) -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.26346 BP_3 282.25 3.16 4602 642925191 XP_008194463.1 3144 0.0e+00 PREDICTED: myelin regulatory factor isoform X4 [Tribolium castaneum]>gi|270008766|gb|EFA05214.1| hypothetical protein TcasGA2_TC015354 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.23893e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1205 2.3e-130 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF10152//PF05224 Predicted coiled-coil domain-containing protein (DUF2360)//NDT80 / PhoG like DNA-binding family -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.26347 BP_3 20.30 3.54 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26348 BP_3 819.54 17.98 2489 91092950 XP_972452.1 3109 0.0e+00 PREDICTED: probable glutamine--tRNA ligase [Tribolium castaneum]>gi|270003024|gb|EEZ99471.1| hypothetical protein TcasGA2_TC000042 [Tribolium castaneum] 815821208 XM_012376424.1 182 7.54819e-88 PREDICTED: Linepithema humile probable glutamine--tRNA ligase (LOC105677665), mRNA K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 2657 5.3e-299 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 PF04558//PF04557//PF00749//PF03950 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//tRNA synthetases class I (E and Q), catalytic domain//tRNA synthetases class I (E and Q), anti-codon binding domain GO:0006425//GO:0043039//GO:0006418 glutaminyl-tRNA aminoacylation//tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0005524//GO:0016876//GO:0004812//GO:0000166//GO:0004819 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity//nucleotide binding//glutamine-tRNA ligase activity GO:0005737 cytoplasm KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.26349 BP_3 7.73 0.31 1480 91092950 XP_972452.1 1173 9.2e-126 PREDICTED: probable glutamine--tRNA ligase [Tribolium castaneum]>gi|270003024|gb|EEZ99471.1| hypothetical protein TcasGA2_TC000042 [Tribolium castaneum] -- -- -- -- -- K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 930 5.7e-99 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 PF04558//PF04557//PF07499//PF00749 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//RuvA, C-terminal domain//tRNA synthetases class I (E and Q), catalytic domain GO:0006310//GO:0006418//GO:0043039//GO:0006425//GO:0006281 DNA recombination//tRNA aminoacylation for protein translation//tRNA aminoacylation//glutaminyl-tRNA aminoacylation//DNA repair GO:0000166//GO:0004819//GO:0004812//GO:0009378//GO:0016876//GO:0005524 nucleotide binding//glutamine-tRNA ligase activity//aminoacyl-tRNA ligase activity//four-way junction helicase activity//ligase activity, forming aminoacyl-tRNA and related compounds//ATP binding GO:0005737//GO:0005657//GO:0009379 cytoplasm//replication fork//Holliday junction helicase complex KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.26350 BP_3 346.00 22.87 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26352 BP_3 106.00 2.98 2004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26354 BP_3 74.48 0.99 3901 642927147 XP_008195157.1 3612 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12024 425 5.5e-40 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.26357 BP_3 27.42 0.39 3650 642936562 XP_008198486.1 1449 2.3e-157 PREDICTED: somatostatin receptor type 2 isoform X1 [Tribolium castaneum] 462360042 APGK01029530.1 119 1.16769e-52 Dendroctonus ponderosae Seq01029540, whole genome shotgun sequence K04218 SSTR2 somatostatin receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04218 P30874 580 5.4e-58 Somatostatin receptor type 2 OS=Homo sapiens GN=SSTR2 PE=1 SV=1 PF00001//PF13994 7 transmembrane receptor (rhodopsin family)//PgaD-like protein GO:0007186//GO:0042710 G-protein coupled receptor signaling pathway//biofilm formation GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.26358 BP_3 23.00 8.92 415 241238985 XP_002401441.1 205 4.6e-14 52 kD repressor of inhibitor of protein kinase, putative [Ixodes scapularis]>gi|215496163|gb|EEC05804.1| 52 kD repressor of inhibitor of protein kinase, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- O43422 189 1.3e-13 52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens GN=PRKRIR PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.26361 BP_3 159.00 9.16 1128 270015869 EFA12317.1 327 8.8e-28 hypothetical protein TcasGA2_TC004218 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01184 GPR1/FUN34/yaaH family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26362 BP_3 26.63 0.94 1653 478251391 ENN71857.1 312 7.1e-26 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 P54726 202 1.7e-14 UV excision repair protein RAD23 homolog A OS=Mus musculus GN=Rad23a PE=1 SV=2 PF09280//PF00995 XPC-binding domain//Sec1 family GO:0006289//GO:0006904//GO:0016192//GO:0006281//GO:0043161 nucleotide-excision repair//vesicle docking involved in exocytosis//vesicle-mediated transport//DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.26363 BP_3 1430.41 44.85 1829 91087253 XP_975524.1 1311 1.1e-141 PREDICTED: uncharacterized protein LOC664424 [Tribolium castaneum]>gi|270009552|gb|EFA06000.1| hypothetical protein TcasGA2_TC008826 [Tribolium castaneum] 820857889 XM_012490556.1 37 2.22253e-07 PREDICTED: Apis florea uncharacterized LOC100871900 (LOC100871900), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26364 BP_3 44.93 0.48 4840 195431192 XP_002063632.1 2212 1.0e-245 GK22019 [Drosophila willistoni]>gi|194159717|gb|EDW74618.1| GK22019 [Drosophila willistoni] 167466191 NM_001114369.1 314 6.18073e-161 Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), mRNA -- -- -- -- Q9VS29 871 1.3e-91 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF16990//PF03910//PF05790//PF04110 Immunoglobulin domain//Carbohydrate binding module (family 35)//Adenovirus minor core protein PV//Immunoglobulin C2-set domain//Ubiquitin-like autophagy protein Apg12 GO:0000045//GO:0007155 autophagosome assembly//cell adhesion GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0005737//GO:0019012//GO:0016021 cytoplasm//virion//integral component of membrane -- -- Cluster-8309.26366 BP_3 14.00 6.44 395 861594808 KMQ83108.1 340 9.6e-30 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26367 BP_3 6.00 11.57 298 795023964 XP_011861119.1 137 2.5e-06 PREDICTED: uncharacterized protein LOC105558173 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26368 BP_3 18.39 4.27 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26369 BP_3 14.00 0.52 1589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26371 BP_3 206.54 2.71 3965 642910771 XP_008193403.1 2225 2.6e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.0e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00620//PF10297//PF00150 RhoGAP domain//Minimal binding motif of Hap4 for binding to Hap2/3/5//Cellulase (glycosyl hydrolase family 5) GO:0006355//GO:0007165//GO:0005975 regulation of transcription, DNA-templated//signal transduction//carbohydrate metabolic process GO:0004553//GO:0003677 hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.26372 BP_3 958.95 7.33 6594 91086487 XP_970606.1 1037 2.4e-109 PREDICTED: putative Rab-43-like protein ENSP00000330714 [Tribolium castaneum]>gi|270009806|gb|EFA06254.1| hypothetical protein TcasGA2_TC009113 [Tribolium castaneum] -- -- -- -- -- K07930 RAB43 Ras-related protein Rab-43 http://www.genome.jp/dbget-bin/www_bget?ko:K07930 Q86YS6 619 2.9e-62 Ras-related protein Rab-43 OS=Homo sapiens GN=RAB43 PE=1 SV=1 PF00096//PF00025//PF14991//PF08477//PF08513//PF01926//PF08710//PF00071//PF10662//PF04670//PF02367 Zinc finger, C2H2 type//ADP-ribosylation factor family//Protein melan-A//Ras of Complex, Roc, domain of DAPkinase//LisH//50S ribosome-binding GTPase//nsp9 replicase//Ras family//Ethanolamine utilisation - propanediol utilisation//Gtr1/RagA G protein conserved region//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0019079//GO:0006576//GO:0007264//GO:0015031//GO:0002949 viral genome replication//cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport//tRNA threonylcarbamoyladenosine modification GO:0005515//GO:0003723//GO:0005524//GO:0046872//GO:0005525 protein binding//RNA binding//ATP binding//metal ion binding//GTP binding GO:0042470 melanosome KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.26373 BP_3 1.00 0.38 418 546678915 ERL89453.1 180 3.6e-11 hypothetical protein D910_06820 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF01844//PF00096//PF13465 C2H2-type zinc finger//HNH endonuclease//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0003676//GO:0004519 metal ion binding//nucleic acid binding//endonuclease activity -- -- KOG1721 FOG: Zn-finger Cluster-8309.26374 BP_3 30.34 0.53 3031 270002437 EEZ98884.1 1717 1.6e-188 hypothetical protein TcasGA2_TC004499 [Tribolium castaneum] -- -- -- -- -- K08155 SLC18A1_2, VMAT MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08155 Q8BRU6 1046 4.1e-112 Synaptic vesicular amine transporter OS=Mus musculus GN=Slc18a2 PE=1 SV=1 PF00083//PF07690//PF02892 Sugar (and other) transporter//Major Facilitator Superfamily//BED zinc finger GO:0055085 transmembrane transport GO:0022857//GO:0003677 transmembrane transporter activity//DNA binding GO:0016021 integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.26376 BP_3 209.55 4.89 2358 478255293 ENN75519.1 1952 6.9e-216 hypothetical protein YQE_07863, partial [Dendroctonus ponderosae]>gi|546683153|gb|ERL93004.1| hypothetical protein D910_10306 [Dendroctonus ponderosae] 572269069 XM_006612496.1 54 1.02053e-16 PREDICTED: Apis dorsata PAB-dependent poly(A)-specific ribonuclease subunit 3-like (LOC102671478), mRNA K12572 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12572 Q95RR8 1315 2.1e-143 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Drosophila melanogaster GN=CG11486 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG3741 Poly(A) ribonuclease subunit Cluster-8309.26377 BP_3 382.17 9.17 2301 478255293 ENN75519.1 1952 6.7e-216 hypothetical protein YQE_07863, partial [Dendroctonus ponderosae]>gi|546683153|gb|ERL93004.1| hypothetical protein D910_10306 [Dendroctonus ponderosae] 572269069 XM_006612496.1 54 9.95489e-17 PREDICTED: Apis dorsata PAB-dependent poly(A)-specific ribonuclease subunit 3-like (LOC102671478), mRNA K12572 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12572 Q95RR8 1315 2.0e-143 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Drosophila melanogaster GN=CG11486 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG3741 Poly(A) ribonuclease subunit Cluster-8309.26378 BP_3 401.00 29.63 944 91088997 XP_967529.1 296 2.9e-24 PREDICTED: cytochrome c oxidase copper chaperone [Tribolium castaneum]>gi|642932591|ref|XP_008196914.1| PREDICTED: cytochrome c oxidase copper chaperone [Tribolium castaneum]>gi|270012381|gb|EFA08829.1| hypothetical protein TcasGA2_TC006526 [Tribolium castaneum] -- -- -- -- -- K02260 COX17 cytochrome c oxidase assembly protein subunit 17 http://www.genome.jp/dbget-bin/www_bget?ko:K02260 Q6J3Q7 218 1.3e-16 Cytochrome c oxidase copper chaperone OS=Canis familiaris GN=COX17 PE=3 SV=3 PF00693//PF11095//PF05051 Thymidine kinase from herpesvirus//Gem-associated protein 7 (Gemin7)//Cytochrome C oxidase copper chaperone (COX17) GO:0006230//GO:0006825//GO:0006206 TMP biosynthetic process//copper ion transport//pyrimidine nucleobase metabolic process GO:0004797//GO:0005507//GO:0016531//GO:0005524 thymidine kinase activity//copper ion binding//copper chaperone activity//ATP binding GO:0032797//GO:0005758 SMN complex//mitochondrial intermembrane space KOG3496 Cytochrome c oxidase assembly protein/Cu2+ chaperone COX17 Cluster-8309.26379 BP_3 46.00 0.85 2889 270004596 EFA01044.1 1057 5.1e-112 hypothetical protein TcasGA2_TC003960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1QEP5 146 9.1e-08 Translation initiation factor IF-2 OS=Psychrobacter cryohalolentis (strain K5) GN=infB PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26380 BP_3 74.34 0.59 6371 189237589 XP_975112.2 9795 0.0e+00 PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|642923840|ref|XP_008193901.1| PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|270006913|gb|EFA03361.1| hypothetical protein TcasGA2_TC013346 [Tribolium castaneum] 642923841 XM_970019.3 1736 0 PREDICTED: Tribolium castaneum myosin 7A (LOC663995), transcript variant X2, mRNA K10359 MYO7 myosin VII http://www.genome.jp/dbget-bin/www_bget?ko:K10359 Q17LW0 9127 0.0e+00 Myosin-VIIa OS=Aedes aegypti GN=ck PE=3 SV=1 PF00788//PF00784//PF00005//PF00018//PF00612//PF00063//PF02367 Ras association (RalGDS/AF-6) domain//MyTH4 domain//ABC transporter//SH3 domain//IQ calmodulin-binding motif//Myosin head (motor domain)//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0002949//GO:0007165 tRNA threonylcarbamoyladenosine modification//signal transduction GO:0003774//GO:0016887//GO:0005524//GO:0005515 motor activity//ATPase activity//ATP binding//protein binding GO:0005856//GO:0016459 cytoskeleton//myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.26381 BP_3 2083.66 14.19 7369 189237589 XP_975112.2 10593 0.0e+00 PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|642923840|ref|XP_008193901.1| PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|270006913|gb|EFA03361.1| hypothetical protein TcasGA2_TC013346 [Tribolium castaneum] 642923841 XM_970019.3 1900 0 PREDICTED: Tribolium castaneum myosin 7A (LOC663995), transcript variant X2, mRNA K10359 MYO7 myosin VII http://www.genome.jp/dbget-bin/www_bget?ko:K10359 Q17LW0 9910 0.0e+00 Myosin-VIIa OS=Aedes aegypti GN=ck PE=3 SV=1 PF00788//PF00640//PF02367//PF00018//PF00005//PF00784//PF00063//PF00612 Ras association (RalGDS/AF-6) domain//Phosphotyrosine interaction domain (PTB/PID)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//SH3 domain//ABC transporter//MyTH4 domain//Myosin head (motor domain)//IQ calmodulin-binding motif GO:0007165//GO:0002949 signal transduction//tRNA threonylcarbamoyladenosine modification GO:0005515//GO:0005524//GO:0016887//GO:0003774 protein binding//ATP binding//ATPase activity//motor activity GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.26383 BP_3 96.47 2.12 2480 91076548 XP_966358.1 499 2.2e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.7e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF05093 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0016226 iron-sulfur cluster assembly GO:0051536 iron-sulfur cluster binding GO:0005737 cytoplasm KOG4020 Protein DRE2, required for cell viability Cluster-8309.26384 BP_3 767.26 8.34 4724 478251184 ENN71660.1 1199 2.9e-128 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K02330 POLB DNA polymerase beta http://www.genome.jp/dbget-bin/www_bget?ko:K02330 O57383 972 2.5e-103 DNA polymerase beta OS=Xenopus laevis GN=polb PE=1 SV=3 PF00328//PF10391//PF00633//PF01367//PF01909 Histidine phosphatase superfamily (branch 2)//Fingers domain of DNA polymerase lambda//Helix-hairpin-helix motif//5'-3' exonuclease, C-terminal SAM fold//Nucleotidyltransferase domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0016779//GO:0003993//GO:0034061//GO:0003824//GO:0003677 nucleotidyltransferase activity//acid phosphatase activity//DNA polymerase activity//catalytic activity//DNA binding GO:0005634 nucleus -- -- Cluster-8309.26385 BP_3 12.03 0.56 1329 478256132 ENN76331.1 922 1.1e-96 hypothetical protein YQE_07294, partial [Dendroctonus ponderosae]>gi|546675874|gb|ERL86979.1| hypothetical protein D910_04382 [Dendroctonus ponderosae] 157114192 XM_001652155.1 125 1.93209e-56 Aedes aegypti AAEL006730-RA partial mRNA K04407 MAP4K4, HGK mitogen-activated protein kinase kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04407 P97820 736 1.6e-76 Mitogen-activated protein kinase kinase kinase kinase 4 OS=Mus musculus GN=Map4k4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26386 BP_3 813.08 12.82 3349 478257725 ENN77868.1 1833 6.2e-202 hypothetical protein YQE_05546, partial [Dendroctonus ponderosae]>gi|546677692|gb|ERL88486.1| hypothetical protein D910_05872 [Dendroctonus ponderosae] -- -- -- -- -- K13578 BMPR1B, ALK6 bone morphogenetic protein receptor type-1B http://www.genome.jp/dbget-bin/www_bget?ko:K13578 O00238 1361 1.4e-148 Bone morphogenetic protein receptor type-1B OS=Homo sapiens GN=BMPR1B PE=1 SV=1 PF08515//PF01064//PF15048//PF08091//PF06293//PF00069//PF07714 Transforming growth factor beta type I GS-motif//Activin types I and II receptor domain//Organic solute transporter subunit beta protein//Spider insecticidal peptide//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468//GO:0015721//GO:0006810//GO:0007178//GO:0009405 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//bile acid and bile salt transport//transport//transmembrane receptor protein serine/threonine kinase signaling pathway//pathogenesis GO:0004672//GO:0016773//GO:0004675//GO:0005215//GO:0046982//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//transmembrane receptor protein serine/threonine kinase activity//transporter activity//protein heterodimerization activity//ATP binding GO:0005576//GO:0016020//GO:0005886 extracellular region//membrane//plasma membrane -- -- Cluster-8309.26387 BP_3 671.89 12.17 2952 91088837 XP_970678.1 1873 1.2e-206 PREDICTED: bone morphogenetic protein receptor type-1B isoform X1 [Tribolium castaneum] -- -- -- -- -- K13578 BMPR1B, ALK6 bone morphogenetic protein receptor type-1B http://www.genome.jp/dbget-bin/www_bget?ko:K13578 O00238 1358 2.7e-148 Bone morphogenetic protein receptor type-1B OS=Homo sapiens GN=BMPR1B PE=1 SV=1 PF07714//PF08091//PF00069//PF06293//PF15048//PF01064//PF08515 Protein tyrosine kinase//Spider insecticidal peptide//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Organic solute transporter subunit beta protein//Activin types I and II receptor domain//Transforming growth factor beta type I GS-motif GO:0016310//GO:0009405//GO:0007178//GO:0006810//GO:0015721//GO:0006468//GO:0009069 phosphorylation//pathogenesis//transmembrane receptor protein serine/threonine kinase signaling pathway//transport//bile acid and bile salt transport//protein phosphorylation//serine family amino acid metabolic process GO:0046982//GO:0005215//GO:0004675//GO:0016773//GO:0004672//GO:0005524 protein heterodimerization activity//transporter activity//transmembrane receptor protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding GO:0005886//GO:0016020//GO:0005576 plasma membrane//membrane//extracellular region -- -- Cluster-8309.26388 BP_3 12.00 0.35 1958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00837 Iodothyronine deiodinase GO:0055114 oxidation-reduction process GO:0004800 thyroxine 5'-deiodinase activity -- -- -- -- Cluster-8309.26389 BP_3 56.44 0.99 3028 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.26392 BP_3 47.54 0.35 6894 270014943 EFA11391.1 3101 0.0e+00 hypothetical protein TcasGA2_TC011551 [Tribolium castaneum] 642910356 XM_008202069.1 422 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 1743 1.4e-192 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.26395 BP_3 1507.99 11.35 6695 270014943 EFA11391.1 6889 0.0e+00 hypothetical protein TcasGA2_TC011551 [Tribolium castaneum] 642910356 XM_008202069.1 1139 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 2612 2.4e-293 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF07714//PF00433//PF00069//PF08826//PF00130//PF01291 Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//DMPK coiled coil domain like//Phorbol esters/diacylglycerol binding domain (C1 domain)//LIF / OSM family GO:0007165//GO:0009069//GO:0006468//GO:0016310//GO:0006955//GO:0035556 signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation//immune response//intracellular signal transduction GO:0005524//GO:0005125//GO:0004672//GO:0004674 ATP binding//cytokine activity//protein kinase activity//protein serine/threonine kinase activity GO:0005576 extracellular region KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.26399 BP_3 34.16 0.31 5528 642934848 XP_008197836.1 2701 2.3e-302 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.72866e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA K10423 CLIP3_4 CAP-Gly domain-containing linker protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10423 Q5JR59 251 1.2e-19 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26400 BP_3 43.09 0.67 3372 91085925 XP_969990.1 570 1.8e-55 PREDICTED: charged multivesicular body protein 4b [Tribolium castaneum]>gi|270009953|gb|EFA06401.1| hypothetical protein TcasGA2_TC009279 [Tribolium castaneum] 827540193 XM_004923412.2 101 1.09323e-42 PREDICTED: Bombyx mori charged multivesicular body protein 4b (LOC101737568), mRNA K12194 CHMP4, SNF7, VPS32 charged multivesicular body protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12194 Q6IQ73 457 9.2e-44 Charged multivesicular body protein 4c OS=Danio rerio GN=chmp4c PE=2 SV=1 PF00293//PF02993//PF08707//PF03357//PF04053//PF02347 NUDIX domain//Minor capsid protein VI//Primase C terminal 2 (PriCT-2)//Snf7//Coatomer WD associated region//Glycine cleavage system P-protein GO:0006886//GO:0016192//GO:0006563//GO:0006544//GO:0055114//GO:0006546//GO:0007034//GO:0006566 intracellular protein transport//vesicle-mediated transport//L-serine metabolic process//glycine metabolic process//oxidation-reduction process//glycine catabolic process//vacuolar transport//threonine metabolic process GO:0005198//GO:0016787//GO:0016817//GO:0004375 structural molecule activity//hydrolase activity//hydrolase activity, acting on acid anhydrides//glycine dehydrogenase (decarboxylating) activity GO:0019028//GO:0030117 viral capsid//membrane coat KOG1656 Protein involved in glucose derepression and pre-vacuolar endosome protein sorting Cluster-8309.26402 BP_3 8.00 4.35 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26404 BP_3 451.00 4.70 4917 646707954 KDR14467.1 1794 3.0e-197 Beta-1-syntrophin [Zootermopsis nevadensis] 742230363 XM_010902633.1 54 2.14363e-16 PREDICTED: Esox lucius syntrophin, alpha 1 (snta1), transcript variant X2, mRNA -- -- -- -- Q13884 1059 2.1e-113 Beta-1-syntrophin OS=Homo sapiens GN=SNTB1 PE=1 SV=3 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3551 Syntrophins (type beta) Cluster-8309.26406 BP_3 220.53 5.45 2243 270009832 EFA06280.1 2878 0.0e+00 hypothetical protein TcasGA2_TC009146 [Tribolium castaneum] 686484113 KM036513.1 190 2.42545e-92 Locusta migratoria Mcm5 mRNA, complete cds K02209 MCM5, CDC46 DNA replication licensing factor MCM5 http://www.genome.jp/dbget-bin/www_bget?ko:K02209 Q9VGW6 2630 6.5e-296 DNA replication licensing factor Mcm5 OS=Drosophila melanogaster GN=Mcm5 PE=1 SV=1 PF07728//PF07726//PF00158//PF00493 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//MCM2/3/5 family GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0005524//GO:0003677//GO:0016887//GO:0008134 ATP binding//DNA binding//ATPase activity//transcription factor binding GO:0005667 transcription factor complex KOG0481 DNA replication licensing factor, MCM5 component Cluster-8309.26409 BP_3 4.37 0.82 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2641 BP_3 7443.71 580.31 910 478254273 ENN74527.1 216 5.3e-15 hypothetical protein YQE_08851, partial [Dendroctonus ponderosae]>gi|546671467|gb|ERL83769.1| hypothetical protein D910_00997 [Dendroctonus ponderosae]>gi|546672146|gb|ERL84147.1| hypothetical protein D910_01508 [Dendroctonus ponderosae]>gi|546674915|gb|ERL86197.1| hypothetical protein D910_03608 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10174//PF02970//PF04111 RIM-binding protein of the cytomatrix active zone//Tubulin binding cofactor A//Autophagy protein Apg6 GO:0007021//GO:0006914 tubulin complex assembly//autophagy GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0048786//GO:0045298 presynaptic active zone//tubulin complex -- -- Cluster-8309.26410 BP_3 177.62 0.83 10546 642928263 XP_001812997.2 1209 4.4e-129 PREDICTED: cyclin-T [Tribolium castaneum] -- -- -- -- -- K15188 CCNT cyclin T http://www.genome.jp/dbget-bin/www_bget?ko:K15188 O96433 290 6.7e-24 Cyclin-T OS=Drosophila melanogaster GN=CycT PE=1 SV=2 PF02317//PF02984//PF00528//PF03604//PF03526 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain//Cyclin, C-terminal domain//Binding-protein-dependent transport system inner membrane component//DNA directed RNA polymerase, 7 kDa subunit//Colicin E1 (microcin) immunity protein GO:0055114//GO:0006955//GO:0030153//GO:0006810//GO:0006206//GO:0006144//GO:0006351 oxidation-reduction process//immune response//bacteriocin immunity//transport//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0050662//GO:0003899//GO:0016491//GO:0015643//GO:0003677 coenzyme binding//DNA-directed RNA polymerase activity//oxidoreductase activity//toxic substance binding//DNA binding GO:0005730//GO:0016020//GO:0019814//GO:0005634 nucleolus//membrane//immunoglobulin complex//nucleus -- -- Cluster-8309.26411 BP_3 107.60 6.55 1083 91080835 XP_970786.1 1073 2.7e-114 PREDICTED: vacuolar-sorting protein SNF8 [Tribolium castaneum]>gi|642919734|ref|XP_008192042.1| PREDICTED: vacuolar-sorting protein SNF8 [Tribolium castaneum]>gi|270005419|gb|EFA01867.1| hypothetical protein TcasGA2_TC007472 [Tribolium castaneum] 820834273 XM_012495487.1 105 2.05563e-45 PREDICTED: Apis florea vacuolar-sorting protein SNF8 (LOC100864896), transcript variant X1, mRNA K12188 SNF8, EAP30 ESCRT-II complex subunit VPS22 http://www.genome.jp/dbget-bin/www_bget?ko:K12188 Q9CZ28 770 1.5e-80 Vacuolar-sorting protein SNF8 OS=Mus musculus GN=Snf8 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3341 RNA polymerase II transcription factor complex subunit Cluster-8309.26412 BP_3 59.09 1.39 2336 805784346 XP_012140054.1 665 1.2e-66 PREDICTED: DNA primase large subunit-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q84WJ2 335 8.9e-30 Probable DNA primase large subunit OS=Arabidopsis thaliana GN=At1g67320 PE=2 SV=2 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896 DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.26415 BP_3 426.66 20.66 1287 332374970 AEE62626.1 877 1.7e-91 unknown [Dendroctonus ponderosae] 826311409 XM_012650547.1 81 5.38472e-32 PREDICTED: Propithecus coquereli anti-silencing function 1A histone chaperone (ASF1A), mRNA K10753 ASF1 histone chaperone ASF1 http://www.genome.jp/dbget-bin/www_bget?ko:K10753 Q9V464 699 3.0e-72 Histone chaperone asf1 OS=Drosophila melanogaster GN=asf1 PE=1 SV=1 PF04729 ASF1 like histone chaperone GO:0006333 chromatin assembly or disassembly -- -- GO:0005634 nucleus KOG3265 Histone chaperone involved in gene silencing Cluster-8309.26417 BP_3 81.81 0.99 4292 546677720 ERL88511.1 1320 2.4e-142 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 3.98913e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 977 5.9e-104 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.26418 BP_3 574.03 6.80 4358 546677720 ERL88511.1 1304 1.8e-140 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 4.05099e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 964 1.9e-102 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.26419 BP_3 195.07 5.27 2075 546677720 ERL88511.1 930 1.9e-97 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 1.91268e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 571 3.4e-57 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.26421 BP_3 323.00 9.75 1889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26422 BP_3 682.29 15.90 2360 478256027 ENN76226.1 1030 5.6e-109 hypothetical protein YQE_07193, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26423 BP_3 10.02 0.85 862 270003399 EEZ99846.1 252 3.4e-19 hypothetical protein TcasGA2_TC002628 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 166 1.3e-10 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.26425 BP_3 587.72 6.06 4967 270007830 EFA04278.1 3072 0.0e+00 hypothetical protein TcasGA2_TC014568 [Tribolium castaneum] 642924109 XM_008195787.1 569 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1466 1.4e-160 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF07714//PF00069//PF06293//PF07463 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//NUMOD4 motif GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0016788//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//hydrolase activity, acting on ester bonds//protein kinase activity GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.26430 BP_3 656.36 7.73 4384 642918597 XP_008197482.1 3546 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 4B-like [Tribolium castaneum] 642918596 XM_008199260.1 294 7.33947e-150 PREDICTED: Tribolium castaneum pleckstrin homology domain-containing family G member 4B-like (LOC656506), mRNA -- -- -- -- Q58EX7 915 9.3e-97 Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1 PF00739//PF00621 Trans-activation protein X//RhoGEF domain GO:0019079//GO:0035023//GO:0043087 viral genome replication//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.26431 BP_3 1208.89 14.28 4372 642918597 XP_008197482.1 3555 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 4B-like [Tribolium castaneum] 642918596 XM_008199260.1 294 7.31921e-150 PREDICTED: Tribolium castaneum pleckstrin homology domain-containing family G member 4B-like (LOC656506), mRNA -- -- -- -- Q58EX7 915 9.3e-97 Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1 PF00745//PF00739//PF00621 Glutamyl-tRNAGlu reductase, dimerisation domain//Trans-activation protein X//RhoGEF domain GO:0035023//GO:0019079//GO:0033014//GO:0043087//GO:0055114 regulation of Rho protein signal transduction//viral genome replication//tetrapyrrole biosynthetic process//regulation of GTPase activity//oxidation-reduction process GO:0008883//GO:0050661//GO:0005089 glutamyl-tRNA reductase activity//NADP binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.26432 BP_3 73.19 0.40 9014 642923445 XP_008193747.1 789 1.9e-80 PREDICTED: COP9 signalosome complex subunit 8 [Tribolium castaneum]>gi|270008317|gb|EFA04765.1| hypothetical protein TcasGA2_TC030655 [Tribolium castaneum] -- -- -- -- -- K12181 COPS8, CSN8 COP9 signalosome complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12181 Q6GQA6 469 1.0e-44 COP9 signalosome complex subunit 8 OS=Xenopus laevis GN=csn8 PE=2 SV=2 PF01399//PF04069 PCI domain//Substrate binding domain of ABC-type glycine betaine transport system GO:0006810 transport GO:0005515//GO:0005215 protein binding//transporter activity -- -- -- -- Cluster-8309.26434 BP_3 9.00 0.36 1484 270014926 EFA11374.1 410 2.8e-37 hypothetical protein TcasGA2_TC011533 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00430//PF11657//PF05478//PF01442//PF04108//PF07464//PF12153//PF09090//PF04513 ATP synthase B/B' CF(0)//Transcriptional activator TraM//Prominin//Apolipoprotein A1/A4/E domain//Autophagy protein Apg17//Apolipophorin-III precursor (apoLp-III)//LPS binding domain of CAP18 (C terminal)//MIF4G like//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0042157//GO:0016070//GO:0006869//GO:0015986//GO:0042742//GO:0006914//GO:0015992//GO:0009372 lipoprotein metabolic process//RNA metabolic process//lipid transport//ATP synthesis coupled proton transport//defense response to bacterium//autophagy//proton transport//quorum sensing GO:0008289//GO:0005198//GO:0015078 lipid binding//structural molecule activity//hydrogen ion transmembrane transporter activity GO:0019031//GO:0005576//GO:0016021//GO:0019028//GO:0045263 viral envelope//extracellular region//integral component of membrane//viral capsid//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.26435 BP_3 309.29 27.64 831 91088191 XP_972764.1 470 1.7e-44 PREDICTED: ribonuclease UK114 [Tribolium castaneum]>gi|270012137|gb|EFA08585.1| hypothetical protein TcasGA2_TC006240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52758 383 8.6e-36 Ribonuclease UK114 OS=Homo sapiens GN=HRSP12 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2317 Putative translation initiation inhibitor UK114/IBM1 Cluster-8309.26437 BP_3 10.94 0.36 1739 642933063 XP_008197247.1 891 5.4e-93 PREDICTED: rab GTPase-binding effector protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35551 211 1.6e-15 Rab GTPase-binding effector protein 1 OS=Mus musculus GN=Rabep1 PE=1 SV=2 PF05121//PF09726//PF03131//PF09208//PF04799//PF05028//PF13851//PF04111//PF03528 Gas vesicle protein K//Transmembrane protein//bZIP Maf transcription factor//Restriction endonuclease MspI//fzo-like conserved region//Poly (ADP-ribose) glycohydrolase (PARG)//Growth-arrest specific micro-tubule binding//Autophagy protein Apg6//Rabaptin GO:0007165//GO:0031412//GO:0006914//GO:0009307//GO:0006355//GO:0005975//GO:0040007//GO:0008283//GO:0048870//GO:0008053//GO:0006308 signal transduction//gas vesicle organization//autophagy//DNA restriction-modification system//regulation of transcription, DNA-templated//carbohydrate metabolic process//growth//cell proliferation//cell motility//mitochondrial fusion//DNA catabolic process GO:0005096//GO:0003924//GO:0008083//GO:0009036//GO:0003677//GO:0004649 GTPase activator activity//GTPase activity//growth factor activity//Type II site-specific deoxyribonuclease activity//DNA binding//poly(ADP-ribose) glycohydrolase activity GO:0031514//GO:0016021//GO:0005634//GO:0009359//GO:0005741 motile cilium//integral component of membrane//nucleus//Type II site-specific deoxyribonuclease complex//mitochondrial outer membrane -- -- Cluster-8309.26441 BP_3 735.41 33.85 1339 478250947 ENN71431.1 845 9.0e-88 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] 642939405 XM_008195063.1 207 5.07952e-102 PREDICTED: Tribolium castaneum uncharacterized LOC661130 (LOC661130), mRNA -- -- -- -- Q61830 178 8.2e-12 Macrophage mannose receptor 1 OS=Mus musculus GN=Mrc1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26443 BP_3 14.00 0.43 1848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26444 BP_3 96.00 3.01 1830 -- -- -- -- -- 764020144 NR_002819.3 1770 0 Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), long non-coding RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26445 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26446 BP_3 11.67 0.70 1098 642938300 XP_008192786.1 431 7.5e-40 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X1 [Tribolium castaneum]>gi|642938302|ref|XP_008192794.1| PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X1 [Tribolium castaneum] 642938313 XM_008194605.1 195 1.94261e-95 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X8, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26447 BP_3 1282.71 14.86 4453 478252002 ENN72437.1 1467 2.3e-159 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 158 2.98185e-74 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 1027 9.7e-110 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF16588//PF00275//PF13014//PF00098//PF08273//PF03604//PF00013 C2H2 zinc-finger//EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)//KH domain//Zinc knuckle//Zinc-binding domain of primase-helicase//DNA directed RNA polymerase, 7 kDa subunit//KH domain GO:0006144//GO:0006351//GO:0006206//GO:0006269 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//DNA replication, synthesis of RNA primer GO:0003896//GO:0003677//GO:0003723//GO:0004386//GO:0003899//GO:0016765//GO:0003676//GO:0008270 DNA primase activity//DNA binding//RNA binding//helicase activity//DNA-directed RNA polymerase activity//transferase activity, transferring alkyl or aryl (other than methyl) groups//nucleic acid binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.2645 BP_3 11.00 0.40 1619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26451 BP_3 362.29 2.11 8570 642934826 XP_008197826.1 4064 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61460 1854 2.4e-205 DEP domain-containing protein 5 OS=Mus musculus GN=Depdc5 PE=1 SV=2 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.26452 BP_3 884.86 10.49 4356 642910567 XP_008200269.1 3542 0.0e+00 PREDICTED: patj homolog [Tribolium castaneum] -- -- -- -- -- K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 O55164 1058 2.4e-113 Multiple PDZ domain protein OS=Rattus norvegicus GN=Mpdz PE=1 SV=1 PF05965//PF00595//PF13180 F/Y rich C-terminus//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding GO:0005634 nucleus KOG3528 FOG: PDZ domain Cluster-8309.26453 BP_3 29.00 1.27 1395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26456 BP_3 117.27 0.47 12218 270015676 EFA12124.1 1367 2.4e-147 hypothetical protein TcasGA2_TC002270 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643//PF05485 B-box zinc finger//THAP domain -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.26457 BP_3 1064.21 20.56 2787 642937990 XP_008199160.1 1379 2.3e-149 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X2 [Tribolium castaneum]>gi|642937992|ref|XP_008199161.1| PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643 B-box zinc finger -- -- GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.26458 BP_3 580.35 2.24 12762 642926088 XP_008194761.1 1377 1.8e-148 PREDICTED: uncharacterized protein LOC103313398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 153 6.2e-08 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF01222//PF02990//PF15220 Ergosterol biosynthesis ERG4/ERG24 family//Endomembrane protein 70//Hypoxia-inducible lipid droplet-associated GO:0008284//GO:0010884//GO:0001819 positive regulation of cell proliferation//positive regulation of lipid storage//positive regulation of cytokine production -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.26459 BP_3 163.91 2.03 4184 189238206 XP_969047.2 3357 0.0e+00 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum] 512920866 XM_004929683.1 38 1.42833e-07 PREDICTED: Bombyx mori bumetanide-sensitive sodium-(potassium)-chloride cotransporter-like (LOC101736988), partial mRNA K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 2236 5.9e-250 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522//PF00895//PF13520 Amino acid permease//Solute carrier family 12//ATP synthase protein 8//Amino acid permease GO:0006811//GO:0015992//GO:0003333//GO:0015986//GO:0006810//GO:0055085//GO:0006865 ion transport//proton transport//amino acid transmembrane transport//ATP synthesis coupled proton transport//transport//transmembrane transport//amino acid transport GO:0015078//GO:0005215//GO:0015171 hydrogen ion transmembrane transporter activity//transporter activity//amino acid transmembrane transporter activity GO:0016020//GO:0000276 membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2083 Na+/K+ symporter Cluster-8309.26460 BP_3 38.60 0.51 3927 642918312 XP_008191454.1 1865 1.4e-205 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.84913e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 P47245 1250 1.2e-135 Nardilysin OS=Rattus norvegicus GN=Nrd1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.26461 BP_3 13.66 0.39 1999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26464 BP_3 24.15 1.38 1134 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2647 BP_3 26.66 0.42 3324 642920773 XP_008192554.1 2931 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: spondin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 895 1.5e-94 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.26470 BP_3 71.87 0.91 4103 546684171 ERL93876.1 1173 2.6e-125 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P57775 470 3.5e-45 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF00400//PF00646//PF01442//PF15966//PF12937//PF03357 WD domain, G-beta repeat//F-box domain//Apolipoprotein A1/A4/E domain//F-box//F-box-like//Snf7 GO:0042157//GO:0006869//GO:0007034 lipoprotein metabolic process//lipid transport//vacuolar transport GO:0008289//GO:0005515 lipid binding//protein binding GO:0005576 extracellular region KOG2911 Uncharacterized conserved protein Cluster-8309.26473 BP_3 51.68 3.63 978 189236224 XP_972065.2 518 5.5e-50 PREDICTED: Golgi resident protein GCP60 [Tribolium castaneum]>gi|270005782|gb|EFA02230.1| hypothetical protein TcasGA2_TC007892 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H3P7 246 7.8e-20 Golgi resident protein GCP60 OS=Homo sapiens GN=ACBD3 PE=1 SV=4 PF05672//PF00887 MAP7 (E-MAP-115) family//Acyl CoA binding protein GO:0006810//GO:0000226 transport//microtubule cytoskeleton organization GO:0000062 fatty-acyl-CoA binding GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane KOG3878 Protein involved in maintenance of Golgi structure and ER-Golgi transport Cluster-8309.26475 BP_3 4.00 1.37 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26478 BP_3 154.33 0.95 8093 123407101 XP_001302933.1 225 4.3e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.5e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26481 BP_3 1929.90 20.04 4934 642920972 XP_008192636.1 5689 0.0e+00 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12879 THOC2 THO complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12879 B0KWH8 2984 0.0e+00 THO complex subunit 2 OS=Callithrix jacchus GN=THOC2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1874 KEKE-like motif-containing transcription regulator (Rlr1)/suppressor of sin4 Cluster-8309.26482 BP_3 69.98 0.67 5353 642920972 XP_008192636.1 5640 0.0e+00 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12879 THOC2 THO complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12879 B0KWH8 2984 0.0e+00 THO complex subunit 2 OS=Callithrix jacchus GN=THOC2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1874 KEKE-like motif-containing transcription regulator (Rlr1)/suppressor of sin4 Cluster-8309.26484 BP_3 246.61 5.99 2277 642920972 XP_008192636.1 276 1.5e-21 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF01608//PF15741 Outer membrane protein (OmpH-like)//I/LWEQ domain//Ligand-dependent nuclear receptor-interacting factor 1 GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003779//GO:0042974//GO:0051082 actin binding//retinoic acid receptor binding//unfolded protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.26485 BP_3 107.70 4.26 1509 642920972 XP_008192636.1 269 6.3e-21 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15741 Ligand-dependent nuclear receptor-interacting factor 1 GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0042974 retinoic acid receptor binding GO:0005667 transcription factor complex -- -- Cluster-8309.26487 BP_3 66.89 4.10 1078 478260397 ENN80137.1 655 7.8e-66 hypothetical protein YQE_03429, partial [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P20432 578 2.7e-58 Glutathione S-transferase 1-1 OS=Drosophila melanogaster GN=GstD1 PE=1 SV=1 PF04371//PF13409//PF13417//PF02798 Porphyromonas-type peptidyl-arginine deiminase//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006807//GO:0009446 nitrogen compound metabolic process//putrescine biosynthetic process GO:0004668//GO:0005515 protein-arginine deiminase activity//protein binding -- -- -- -- Cluster-8309.26489 BP_3 224.90 4.23 2853 189240369 XP_973831.2 1066 4.6e-113 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X4 [Tribolium castaneum] 642932786 XM_968738.3 205 1.41902e-100 PREDICTED: Tribolium castaneum dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (LOC662654), transcript variant X8, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 849 2.7e-89 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.2649 BP_3 17.00 0.88 1227 642922027 XP_008192990.1 304 4.5e-25 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270007271|gb|EFA03719.1| hypothetical protein TcasGA2_TC013824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 252 2.0e-20 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.26493 BP_3 22.69 0.62 2044 91087311 XP_975575.1 1011 7.8e-107 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K14291 PHAX phosphorylated adapter RNA export protein http://www.genome.jp/dbget-bin/www_bget?ko:K14291 Q5ZLY0 263 1.7e-21 Phosphorylated adapter RNA export protein OS=Gallus gallus GN=PHAX PE=2 SV=1 PF01287//PF09415 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//CENP-S associating Centromere protein X GO:0006281//GO:0006448//GO:0006452//GO:0051382//GO:0045901//GO:0045905 DNA repair//regulation of translational elongation//translational frameshifting//kinetochore assembly//positive regulation of translational elongation//positive regulation of translational termination GO:0043022//GO:0003723//GO:0003746 ribosome binding//RNA binding//translation elongation factor activity GO:0005840 ribosome KOG3948 Mediator of U snRNA nuclear export PHAX Cluster-8309.26496 BP_3 77.33 1.06 3812 755959126 XP_011304294.1 2062 2.0e-228 PREDICTED: eukaryotic peptide chain release factor subunit 1 isoform X2 [Fopius arisanus] 642912506 XM_966575.3 578 0 PREDICTED: Tribolium castaneum eukaryotic peptide chain release factor subunit 1 (LOC660337), mRNA K03265 ETF1, ERF1 peptide chain release factor subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03265 Q9VPH7 2033 1.9e-226 Eukaryotic peptide chain release factor subunit 1 OS=Drosophila melanogaster GN=eRF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0688 Peptide chain release factor 1 (eRF1) Cluster-8309.26497 BP_3 51.37 0.96 2876 91077680 XP_974637.1 1934 1.0e-213 PREDICTED: pre-mRNA-splicing factor Slu7 [Tribolium castaneum]>gi|270001533|gb|EEZ97980.1| hypothetical protein TcasGA2_TC000375 [Tribolium castaneum] 762095952 XM_011432193.1 51 5.80295e-15 PREDICTED: Crassostrea gigas pre-mRNA-splicing factor SLU7-like (LOC105330483), transcript variant X2, mRNA K12819 SLU7 pre-mRNA-processing factor SLU7 http://www.genome.jp/dbget-bin/www_bget?ko:K12819 Q9VAQ7 1403 1.6e-153 Pre-mRNA-splicing factor Slu7 OS=Drosophila melanogaster GN=Slu7 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2560 RNA splicing factor - Slu7p Cluster-8309.26499 BP_3 73.78 2.41 1767 642918788 XP_008191584.1 2478 5.2e-277 PREDICTED: uncharacterized protein LOC660407 isoform X1 [Tribolium castaneum] 642918789 XM_008193363.1 545 0 PREDICTED: Tribolium castaneum uncharacterized LOC660407 (LOC660407), transcript variant X2, mRNA -- -- -- -- P47736 647 4.5e-66 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF02145//PF02724 Rap/ran-GAP//CDC45-like protein GO:0051056//GO:0006270 regulation of small GTPase mediated signal transduction//DNA replication initiation GO:0005096 GTPase activator activity -- -- KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.26500 BP_3 91.83 1.53 3180 642917169 XP_008191148.1 800 3.5e-82 PREDICTED: centrosomin isoform X1 [Tribolium castaneum]>gi|270004823|gb|EFA01271.1| centrosomin [Tribolium castaneum] -- -- -- -- -- K16542 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16542 Q9BE52 240 1.3e-18 CDK5 regulatory subunit-associated protein 2 OS=Macaca fascicularis GN=CDK5RAP2 PE=2 SV=1 PF07989//PF02183//PF00769 Centrosomin N-terminal motif 1//Homeobox associated leucine zipper//Ezrin/radixin/moesin family GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0008092 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//cytoskeletal protein binding GO:0005737//GO:0019898//GO:0005815//GO:0005667 cytoplasm//extrinsic component of membrane//microtubule organizing center//transcription factor complex -- -- Cluster-8309.26501 BP_3 1301.86 31.61 2277 646691019 KDR07011.1 2372 1.3e-264 WD40 repeat-containing protein SMU1 [Zootermopsis nevadensis] 332372781 BT126569.1 448 0 Dendroctonus ponderosae clone DPO1120_B10 unknown mRNA K13111 SMU1 WD40 repeat-containing protein SMU1 http://www.genome.jp/dbget-bin/www_bget?ko:K13111 Q5ZME8 2226 4.6e-249 WD40 repeat-containing protein SMU1 OS=Gallus gallus GN=SMU1 PE=2 SV=1 PF07569//PF00400 TUP1-like enhancer of split//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0275 Conserved WD40 repeat-containing protein Cluster-8309.26503 BP_3 19.04 0.47 2246 642939368 XP_008193127.1 459 8.7e-43 PREDICTED: uncharacterized protein LOC103312950 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09085//PF04442//PF13895 Adhesion molecule, immunoglobulin-like//Cytochrome c oxidase assembly protein CtaG/Cox11//Immunoglobulin domain GO:0007155 cell adhesion GO:0005515//GO:0005507 protein binding//copper ion binding GO:0016020 membrane -- -- Cluster-8309.26504 BP_3 96.40 2.42 2208 642939368 XP_008193127.1 467 1.0e-43 PREDICTED: uncharacterized protein LOC103312950 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04442//PF13895//PF09085 Cytochrome c oxidase assembly protein CtaG/Cox11//Immunoglobulin domain//Adhesion molecule, immunoglobulin-like GO:0007155 cell adhesion GO:0005515//GO:0005507 protein binding//copper ion binding GO:0016020 membrane -- -- Cluster-8309.26505 BP_3 1391.14 43.34 1839 91077822 XP_970776.1 1374 5.7e-149 PREDICTED: uncharacterized protein LOC659370 [Tribolium castaneum]>gi|642914539|ref|XP_008201719.1| PREDICTED: uncharacterized protein LOC659370 [Tribolium castaneum]>gi|270001483|gb|EEZ97930.1| hypothetical protein TcasGA2_TC000317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01073//PF01370//PF03435//PF00056 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008210//GO:0044237//GO:0008207//GO:0008209//GO:0006694//GO:0055114 estrogen metabolic process//cellular metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0016491//GO:0000166 coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.26506 BP_3 1218.91 15.94 3977 91092680 XP_971368.1 4473 0.0e+00 PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911362|ref|XP_008199390.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911364|ref|XP_008199391.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911366|ref|XP_008199393.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|270014815|gb|EFA11263.1| hypothetical protein TcasGA2_TC010798 [Tribolium castaneum] 815809952 XM_012370439.1 590 0 PREDICTED: Linepithema humile AP-2 complex subunit alpha (LOC105674243), transcript variant X2, mRNA K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q7QG73 3987 0.0e+00 AP-2 complex subunit alpha OS=Anopheles gambiae GN=alpha-Adaptin PE=3 SV=4 PF01602//PF02296//PF09090//PF02985//PF02883 Adaptin N terminal region//Alpha adaptin AP2, C-terminal domain//MIF4G like//HEAT repeat//Adaptin C-terminal domain GO:0015031//GO:0006886//GO:0016192//GO:0016070 protein transport//intracellular protein transport//vesicle-mediated transport//RNA metabolic process GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.26507 BP_3 62.89 0.80 4083 91092680 XP_971368.1 3269 0.0e+00 PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911362|ref|XP_008199390.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911364|ref|XP_008199391.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911366|ref|XP_008199393.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|270014815|gb|EFA11263.1| hypothetical protein TcasGA2_TC010798 [Tribolium castaneum] 826423166 XM_012671160.1 402 0 PREDICTED: Monomorium pharaonis AP-2 complex subunit alpha (LOC105831182), mRNA K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q7QG73 2831 0.0e+00 AP-2 complex subunit alpha OS=Anopheles gambiae GN=alpha-Adaptin PE=3 SV=4 PF02296//PF01347//PF02985//PF09090//PF02883//PF01602 Alpha adaptin AP2, C-terminal domain//Lipoprotein amino terminal region//HEAT repeat//MIF4G like//Adaptin C-terminal domain//Adaptin N terminal region GO:0015031//GO:0016192//GO:0006886//GO:0016070//GO:0006869 protein transport//vesicle-mediated transport//intracellular protein transport//RNA metabolic process//lipid transport GO:0008565//GO:0005515//GO:0005319 protein transporter activity//protein binding//lipid transporter activity GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.26508 BP_3 78.43 2.62 1733 478253848 ENN74140.1 681 1.2e-68 hypothetical protein YQE_09113, partial [Dendroctonus ponderosae]>gi|546684654|gb|ERL94271.1| hypothetical protein D910_11552 [Dendroctonus ponderosae] -- -- -- -- -- K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q29N38 565 1.4e-56 AP-2 complex subunit alpha OS=Drosophila pseudoobscura pseudoobscura GN=alpha-Adaptin PE=3 SV=1 PF02296//PF09066//PF02883 Alpha adaptin AP2, C-terminal domain//Beta2-adaptin appendage, C-terminal sub-domain//Adaptin C-terminal domain GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport -- -- GO:0030131 clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.26513 BP_3 3.74 1.57 405 642918318 XP_008191457.1 463 5.4e-44 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642918317 XM_008193235.1 137 1.18617e-63 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC656006), mRNA K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9VS29 218 5.7e-17 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26514 BP_3 473.09 4.02 5965 478257810 ENN77953.1 2106 2.4e-233 hypothetical protein YQE_05630, partial [Dendroctonus ponderosae] -- -- -- -- -- K14833 NOC2 nucleolar complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14833 Q9VIF0 1452 6.8e-159 Nucleolar complex protein 2 homolog OS=Drosophila melanogaster GN=CG9246 PE=1 SV=1 PF01292//PF00083//PF07690 Prokaryotic cytochrome b561//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006118 transmembrane transport//obsolete electron transport GO:0022857//GO:0009055 transmembrane transporter activity//electron carrier activity GO:0016021 integral component of membrane KOG2256 Predicted protein involved in nuclear export of pre-ribosomes Cluster-8309.26516 BP_3 6.00 1.51 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26517 BP_3 22.50 0.61 2074 270014308 EFA10756.1 1309 2.2e-141 cytochrome P450-like protein [Tribolium castaneum] 826490357 XM_012684512.1 42 4.19717e-10 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105838744), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 909 2.2e-96 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.26518 BP_3 192.94 4.22 2494 91094127 XP_968492.1 2115 9.2e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 4.0e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0030145//GO:0008235//GO:0004177 manganese ion binding//metalloexopeptidase activity//aminopeptidase activity GO:0005737//GO:0005622 cytoplasm//intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.2652 BP_3 1.00 0.69 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26520 BP_3 28.30 3.80 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26522 BP_3 741.50 10.34 3748 270010886 EFA07334.1 2927 0.0e+00 hypothetical protein TcasGA2_TC015930 [Tribolium castaneum] -- -- -- -- -- K05288 PIGO phosphatidylinositol glycan, class O http://www.genome.jp/dbget-bin/www_bget?ko:K05288 Q8TEQ8 805 4.5e-84 GPI ethanolamine phosphate transferase 3 OS=Homo sapiens GN=PIGO PE=1 SV=3 PF01676//PF01663//PF00884 Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824//GO:0046872 sulfuric ester hydrolase activity//catalytic activity//metal ion binding -- -- KOG2125 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.26527 BP_3 125.11 1.91 3457 91085733 XP_973505.1 2855 0.0e+00 PREDICTED: tRNA (cytosine(34)-C(5))-methyltransferase [Tribolium castaneum] -- -- -- -- -- K15335 NSUN2 tRNA (cytosine34-C5)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15335 Q9W4M9 1723 1.5e-190 tRNA (cytosine(34)-C(5))-methyltransferase OS=Drosophila melanogaster GN=Nsun2 PE=2 SV=1 PF01728//PF01189 FtsJ-like methyltransferase//16S rRNA methyltransferase RsmF GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2198 tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily Cluster-8309.26528 BP_3 52.54 0.41 6532 642936804 XP_008199623.1 6018 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 7.3e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF00910//PF08702//PF00307//PF10473//PF06160//PF07926//PF01832//PF16716//PF00004//PF13851//PF04111//PF01695//PF07728 RNA helicase//Fibrinogen alpha/beta chain family//Calponin homology (CH) domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//TPR/MLP1/MLP2-like protein//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//Bone marrow stromal antigen 2//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//Autophagy protein Apg6//IstB-like ATP binding protein//AAA domain (dynein-related subfamily) GO:0018874//GO:0000921//GO:0048870//GO:0006560//GO:0051607//GO:0030168//GO:0007165//GO:0006525//GO:0051258//GO:0006914//GO:0006568//GO:0006558//GO:0006606//GO:0042207 benzoate metabolic process//septin ring assembly//cell motility//proline metabolic process//defense response to virus//platelet activation//signal transduction//arginine metabolic process//protein polymerization//autophagy//tryptophan metabolic process//L-phenylalanine metabolic process//protein import into nucleus//styrene catabolic process GO:0003723//GO:0004040//GO:0005515//GO:0042803//GO:0030674//GO:0003724//GO:0005524//GO:0008134//GO:0045502//GO:0005102//GO:0016887 RNA binding//amidase activity//protein binding//protein homodimerization activity//protein binding, bridging//RNA helicase activity//ATP binding//transcription factor binding//dynein binding//receptor binding//ATPase activity GO:0030286//GO:0005667//GO:0031514//GO:0016021//GO:0005940//GO:0005577 dynein complex//transcription factor complex//motile cilium//integral component of membrane//septin ring//fibrinogen complex -- -- Cluster-8309.26530 BP_3 291.48 1.88 7763 642935642 XP_008198095.1 2468 3.3e-275 PREDICTED: rho GTPase-activating protein 21-B isoform X4 [Tribolium castaneum] 642935647 XM_008199876.1 210 6.46452e-103 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.3e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF11973//PF13180//PF00620//PF00595 Glycolipid transfer protein (GLTP)//NQRA C-terminal domain//PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF) GO:0055114//GO:0006118//GO:0046836//GO:0007165 oxidation-reduction process//obsolete electron transport//glycolipid transport//signal transduction GO:0016655//GO:0051861//GO:0005515//GO:0017089 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//glycolipid binding//protein binding//glycolipid transporter activity GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.26531 BP_3 15.16 0.44 1948 642927580 XP_008195323.1 2141 6.9e-238 PREDICTED: uncharacterized protein LOC661513 isoform X1 [Tribolium castaneum]>gi|642927582|ref|XP_008195324.1| PREDICTED: uncharacterized protein LOC661513 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08300 Hepatitis C virus non-structural 5a zinc finger domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.26532 BP_3 131.00 4.05 1849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26537 BP_3 507.69 2.65 9517 91089789 XP_968303.1 3082 0.0e+00 PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|642933751|ref|XP_008191514.1| PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|642933753|ref|XP_008191521.1| PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|270013600|gb|EFA10048.1| hypothetical protein TcasGA2_TC012222 [Tribolium castaneum] -- -- -- -- -- K08886 TNK2, ACK1 activated CDC42 kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08886 Q07912 1421 4.3e-155 Activated CDC42 kinase 1 OS=Homo sapiens GN=TNK2 PE=1 SV=3 PF00018//PF02845//PF02535//PF03153//PF05365//PF08115//PF00069//PF07714 SH3 domain//CUE domain//ZIP Zinc transporter//Transcription factor IIA, alpha/beta subunit//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//SFI toxin family//Protein kinase domain//Protein tyrosine kinase GO:0055085//GO:0009405//GO:0006468//GO:0006367//GO:0030001//GO:0006122 transmembrane transport//pathogenesis//protein phosphorylation//transcription initiation from RNA polymerase II promoter//metal ion transport//mitochondrial electron transport, ubiquinol to cytochrome c GO:0016301//GO:0005524//GO:0046873//GO:0004672//GO:0005515 kinase activity//ATP binding//metal ion transmembrane transporter activity//protein kinase activity//protein binding GO:0016020//GO:0005672//GO:0005576//GO:0005743//GO:0005750 membrane//transcription factor TFIIA complex//extracellular region//mitochondrial inner membrane//mitochondrial respiratory chain complex III KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.26538 BP_3 3.00 1.63 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26540 BP_3 2.00 6.41 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26542 BP_3 2.00 0.74 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26544 BP_3 1.00 3.21 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26545 BP_3 662.59 5.94 5671 195381919 XP_002049680.1 2495 1.8e-278 GJ20621 [Drosophila virilis]>gi|194144477|gb|EDW60873.1| GJ20621 [Drosophila virilis] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2489 3.7e-279 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF07714//PF00628//PF00433//PF07649//PF00069//PF00564//PF00130 Protein tyrosine kinase//PHD-finger//Protein kinase C terminal domain//C1-like domain//Protein kinase domain//PB1 domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0016310//GO:0009069//GO:0006468//GO:0055114//GO:0035556 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0008270//GO:0046872//GO:0047134//GO:0004672//GO:0004674 ATP binding//protein binding//zinc ion binding//metal ion binding//protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity GO:0005622 intracellular KOG0694 Serine/threonine protein kinase Cluster-8309.26546 BP_3 189.16 1.70 5653 807015446 XP_012155254.1 2269 2.9e-252 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101458667 [Ceratitis capitata] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2189 2.2e-244 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00130//PF00069//PF00628//PF07649//PF00433//PF07714 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase domain//PHD-finger//C1-like domain//Protein kinase C terminal domain//Protein tyrosine kinase GO:0055114//GO:0035556//GO:0009069//GO:0006468//GO:0016310 oxidation-reduction process//intracellular signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0047134//GO:0005515//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//protein-disulfide reductase activity//protein binding//ATP binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.26547 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26548 BP_3 42.23 0.45 4814 642920287 XP_008192284.1 3601 0.0e+00 PREDICTED: N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1 [Tribolium castaneum]>gi|642920289|ref|XP_008192285.1| PREDICTED: N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1 [Tribolium castaneum] 642920290 XM_970509.2 763 0 PREDICTED: Tribolium castaneum N-alpha-acetyltransferase 16, NatA auxiliary subunit (LOC664508), transcript variant X3, mRNA K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 Q5R4J9 2436 4.4e-273 N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Pongo abelii GN=NAA15 PE=2 SV=1 PF13174//PF03601//PF13181//PF13414//PF06552//PF13176//PF00515//PF13371 Tetratricopeptide repeat//Conserved hypothetical protein 698//Tetratricopeptide repeat//TPR repeat//Plant specific mitochondrial import receptor subunit TOM20//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0045040 protein import into mitochondrial outer membrane GO:0005515 protein binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane KOG1156 N-terminal acetyltransferase Cluster-8309.26549 BP_3 255.00 4.57 2980 478257510 ENN77666.1 2354 2.1e-262 hypothetical protein YQE_05960, partial [Dendroctonus ponderosae] -- -- -- -- -- K17387 KIF23 kinesin family member 23 http://www.genome.jp/dbget-bin/www_bget?ko:K17387 E9Q5G3 1125 2.8e-121 Kinesin-like protein KIF23 OS=Mus musculus GN=Kif23 PE=1 SV=1 PF00225//PF14833//PF08702 Kinesin motor domain//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//Fibrinogen alpha/beta chain family GO:0030168//GO:0007017//GO:0051258//GO:0007165//GO:0007018 platelet activation//microtubule-based process//protein polymerization//signal transduction//microtubule-based movement GO:0005102//GO:0008017//GO:0030674//GO:0003777//GO:0051287//GO:0005524 receptor binding//microtubule binding//protein binding, bridging//microtubule motor activity//NAD binding//ATP binding GO:0005577//GO:0045298//GO:0005874 fibrinogen complex//tubulin complex//microtubule KOG0247 Kinesin-like protein Cluster-8309.2655 BP_3 5.76 0.44 925 478253664 ENN73966.1 423 5.4e-39 hypothetical protein YQE_09422, partial [Dendroctonus ponderosae]>gi|546684439|gb|ERL94082.1| hypothetical protein D910_11364 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26553 BP_3 26.07 1.23 1317 270008369 EFA04817.1 339 4.2e-29 hypothetical protein TcasGA2_TC014867 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NPA5 233 3.4e-18 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF04988//PF13465//PF00096//PF06397 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain -- -- GO:0003677//GO:0046872//GO:0005506 DNA binding//metal ion binding//iron ion binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.26554 BP_3 631.08 6.23 5178 642922636 XP_971090.3 2313 2.1e-257 PREDICTED: uncharacterized protein LOC659719 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 Q6P7W0 366 5.0e-33 Sentrin-specific protease 6 OS=Mus musculus GN=Senp6 PE=2 SV=3 PF02902//PF02944 Ulp1 protease family, C-terminal catalytic domain//BESS motif GO:0006508 proteolysis GO:0008234//GO:0003677 cysteine-type peptidase activity//DNA binding -- -- KOG0779 Protease, Ulp1 family Cluster-8309.26558 BP_3 53.00 1.71 1790 642925105 XP_008194171.1 1052 1.2e-111 PREDICTED: decaprenyl-diphosphate synthase subunit 2-like [Tribolium castaneum]>gi|270008056|gb|EFA04504.1| hypothetical protein TcasGA2_TC014812 [Tribolium castaneum] -- -- -- -- -- K12505 PDSS2 decaprenyl-diphosphate synthase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12505 Q33DR3 506 1.0e-49 Decaprenyl-diphosphate synthase subunit 2 OS=Mus musculus GN=Pdss2 PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.26560 BP_3 1518.85 156.33 760 242017482 XP_002429217.1 419 1.3e-38 myotrophin, putative [Pediculus humanus corporis]>gi|212514106|gb|EEB16479.1| myotrophin, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q7T2B9 295 1.3e-25 Myotrophin OS=Danio rerio GN=mtpn PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26561 BP_3 1193.33 19.68 3214 478251696 ENN72150.1 1468 1.2e-159 hypothetical protein YQE_11207, partial [Dendroctonus ponderosae]>gi|546680948|gb|ERL91122.1| hypothetical protein D910_08463 [Dendroctonus ponderosae] -- -- -- -- -- K14308 NUP54, NUP57 nuclear pore complex protein Nup54 http://www.genome.jp/dbget-bin/www_bget?ko:K14308 Q8BTS4 726 5.6e-75 Nuclear pore complex protein Nup54 OS=Mus musculus GN=Nup54 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3091 Nuclear pore complex, p54 component (sc Nup57) Cluster-8309.26562 BP_3 16.20 0.53 1770 642912671 XP_969018.2 897 1.1e-93 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 P28039 495 1.9e-48 Acyloxyacyl hydrolase OS=Homo sapiens GN=AOAH PE=1 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26563 BP_3 17.14 0.54 1811 642912671 XP_969018.2 897 1.1e-93 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 O35298 533 7.6e-53 Acyloxyacyl hydrolase OS=Mus musculus GN=Aoah PE=2 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26565 BP_3 8.00 0.36 1375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26566 BP_3 59.70 1.23 2632 189238410 XP_001813192.1 388 1.7e-34 PREDICTED: uncharacterized protein LOC100141684 [Tribolium castaneum]>gi|270008536|gb|EFA04984.1| hypothetical protein TcasGA2_TC015062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26567 BP_3 15.75 0.31 2780 189239830 XP_001813387.1 1166 1.1e-124 PREDICTED: Meckel syndrome type 1 protein [Tribolium castaneum]>gi|270011929|gb|EFA08377.1| hypothetical protein TcasGA2_TC006020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXB0 503 3.5e-49 Meckel syndrome type 1 protein OS=Homo sapiens GN=MKS1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26569 BP_3 183.00 7.56 1458 91088189 XP_972722.1 975 8.3e-103 PREDICTED: dehydrodolichyl diphosphate synthase [Tribolium castaneum]>gi|270012136|gb|EFA08584.1| hypothetical protein TcasGA2_TC006239 [Tribolium castaneum] -- -- -- -- -- K11778 DHDDS, RER2, SRT1 ditrans,polycis-polyprenyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K11778 Q86SQ9 744 2.1e-77 Dehydrodolichyl diphosphate syntase complex subunit DHDDS OS=Homo sapiens GN=DHDDS PE=1 SV=3 PF01255//PF01991 Putative undecaprenyl diphosphate synthase//ATP synthase (E/31 kDa) subunit GO:0015991//GO:0015992//GO:0006119 ATP hydrolysis coupled proton transport//proton transport//oxidative phosphorylation GO:0046961//GO:0016765//GO:0016740 proton-transporting ATPase activity, rotational mechanism//transferase activity, transferring alkyl or aryl (other than methyl) groups//transferase activity GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1602 Cis-prenyltransferase Cluster-8309.26570 BP_3 26.63 0.35 4007 642934681 XP_008197767.1 796 1.3e-81 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X5 [Tribolium castaneum] 642934684 XM_008199547.1 208 4.29944e-102 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 217 7.4e-16 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26571 BP_3 921.47 2.31 19509 642929422 XP_008195833.1 3477 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] 642929421 XM_008197611.1 179 2.7838e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q7TMR0 1024 9.5e-109 Lysosomal Pro-X carboxypeptidase OS=Mus musculus GN=Prcp PE=2 SV=2 PF04574//PF00628//PF14634//PF00536//PF00130//PF00439//PF00400//PF00326//PF06638//PF02198//PF04564//PF07647//PF08926//PF01609//PF11789//PF01221//PF08273//PF01429//PF16367//PF00076//PF05577 Protein of unknown function (DUF592)//PHD-finger//zinc-RING finger domain//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain//WD domain, G-beta repeat//Prolyl oligopeptidase family//Strabismus protein//Sterile alpha motif (SAM)/Pointed domain//U-box domain//SAM domain (Sterile alpha motif)//Domain of unknown function (DUF1908)//Transposase DDE domain//Zinc-finger of the MIZ type in Nse subunit//Dynein light chain type 1//Zinc-binding domain of primase-helicase//Methyl-CpG binding domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Serine carboxypeptidase S28 GO:0006269//GO:0035556//GO:0007275//GO:0006342//GO:0016310//GO:0016567//GO:0006508//GO:0006468//GO:0009069//GO:0007017//GO:0006355//GO:0006476//GO:0006351//GO:0006313//GO:0006807 DNA replication, synthesis of RNA primer//intracellular signal transduction//multicellular organismal development//chromatin silencing//phosphorylation//protein ubiquitination//proteolysis//protein phosphorylation//serine family amino acid metabolic process//microtubule-based process//regulation of transcription, DNA-templated//protein deacetylation//transcription, DNA-templated//transposition, DNA-mediated//nitrogen compound metabolic process GO:0005524//GO:0004674//GO:0008236//GO:0004842//GO:0003676//GO:0004803//GO:0003896//GO:0016811//GO:0017136//GO:0043565//GO:0008270//GO:0003677//GO:0004386//GO:0005515//GO:0051287//GO:0000287 ATP binding//protein serine/threonine kinase activity//serine-type peptidase activity//ubiquitin-protein transferase activity//nucleic acid binding//transposase activity//DNA primase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//NAD-dependent histone deacetylase activity//sequence-specific DNA binding//zinc ion binding//DNA binding//helicase activity//protein binding//NAD binding//magnesium ion binding GO:0005730//GO:0000118//GO:0016021//GO:0005875//GO:0005634//GO:0005657 nucleolus//histone deacetylase complex//integral component of membrane//microtubule associated complex//nucleus//replication fork KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.26576 BP_3 214.82 1.49 7236 270013629 EFA10077.1 304 2.6e-24 hypothetical protein TcasGA2_TC012253 [Tribolium castaneum] -- -- -- -- -- K05668 ABCC5 ATP-binding cassette, subfamily C (CFTR/MRP), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05668 Q9R1X5 168 6.4e-10 Multidrug resistance-associated protein 5 OS=Mus musculus GN=Abcc5 PE=1 SV=2 PF00664//PF01799 ABC transporter transmembrane region//[2Fe-2S] binding domain GO:0055114//GO:0006810//GO:0055085 oxidation-reduction process//transport//transmembrane transport GO:0042626//GO:0046872//GO:0016491//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//metal ion binding//oxidoreductase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.26578 BP_3 49.45 0.82 3204 642933785 XP_008197283.1 3849 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933787|ref|XP_008197292.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933789|ref|XP_008197304.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2326 1.6e-260 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF00437//PF00664//PF13304//PF01926//PF00005//PF17001//PF03193 Type II/IV secretion system protein//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Protein of unknown function, DUF258 GO:0055085//GO:0009306//GO:0006810 transmembrane transport//protein secretion//transport GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.26579 BP_3 76.48 0.48 8026 642918353 XP_008199964.1 4724 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 F1M386 2376 6.6e-266 Rap guanine nucleotide exchange factor 2 OS=Rattus norvegicus GN=Rapgef2 PE=1 SV=2 PF00788//PF13180//PF00617//PF00595 Ras association (RalGDS/AF-6) domain//PDZ domain//RasGEF domain//PDZ domain (Also known as DHR or GLGF) GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.2658 BP_3 4.00 8.90 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26581 BP_3 13.00 0.33 2214 270016306 EFA12752.1 449 1.2e-41 hypothetical protein TcasGA2_TC010279 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26582 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26583 BP_3 426.32 6.50 3452 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.6e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26584 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26585 BP_3 85.30 0.77 5658 642921234 XP_008192774.1 1587 3.5e-173 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X3 [Tribolium castaneum] 642921235 XM_008194553.1 286 2.65731e-145 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 677 4.8e-69 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF00018//PF14604//PF00023//PF06971//PF13606 SH3 domain//Variant SH3 domain//Ankyrin repeat//Putative DNA-binding protein N-terminus//Ankyrin repeat GO:0045892//GO:0051775 negative regulation of transcription, DNA-templated//response to redox state GO:0005515 protein binding GO:0005737 cytoplasm KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.26587 BP_3 188.00 13.30 973 820805570 AKG92776.1 824 1.8e-85 enhancer of split mgamma protein 3 [Leptinotarsa decemlineata] 642932734 XM_967400.3 155 2.95113e-73 PREDICTED: Tribolium castaneum enhancer of split mgamma protein (LOC661225), mRNA K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 Q01069 345 2.6e-31 Enhancer of split mbeta protein OS=Drosophila melanogaster GN=HLHmbeta PE=2 SV=2 PF07527//PF00010 Hairy Orange//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.26588 BP_3 93.11 4.60 1268 642926860 XP_971810.2 262 3.4e-20 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20662 142 1.2e-07 Zinc finger Y-chromosomal protein 2 OS=Mus musculus GN=Zfy2 PE=2 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.26590 BP_3 54.77 1.80 1757 307166389 EFN60526.1 163 1.4e-08 Protein hunchback [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26592 BP_3 77.66 0.88 4556 642935051 XP_008199921.1 1091 9.2e-116 PREDICTED: cerebellar degeneration-related protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26594 BP_3 26.38 0.73 2037 642934605 XP_971300.2 424 9.0e-39 PREDICTED: CD63 antigen [Tribolium castaneum] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q61451 187 1.1e-12 Leukocyte surface antigen CD53 OS=Mus musculus GN=Cd53 PE=2 SV=2 PF00335//PF05149//PF03390//PF00115 Tetraspanin family//Paraflagellar rod protein//2-hydroxycarboxylate transporter family//Cytochrome C and Quinol oxidase polypeptide I GO:0006123//GO:0009060//GO:0015711//GO:0006118//GO:0055114//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration//organic anion transport//obsolete electron transport//oxidation-reduction process//proton transport GO:0005516//GO:0009055//GO:0008514//GO:0020037//GO:0004129//GO:0005506 calmodulin binding//electron carrier activity//organic anion transmembrane transporter activity//heme binding//cytochrome-c oxidase activity//iron ion binding GO:0016021//GO:0031514//GO:0045277 integral component of membrane//motile cilium//respiratory chain complex IV KOG3882 Tetraspanin family integral membrane protein Cluster-8309.26595 BP_3 983.00 27.19 2034 91085957 XP_971290.1 2324 4.3e-259 PREDICTED: phosphatidylinositide phosphatase SAC1 [Tribolium castaneum]>gi|270009938|gb|EFA06386.1| hypothetical protein TcasGA2_TC009264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0I6 1474 6.5e-162 Phosphatidylinositide phosphatase SAC1 OS=Drosophila melanogaster GN=Sac1 PE=2 SV=1 PF02383 SacI homology domain -- -- GO:0042578 phosphoric ester hydrolase activity -- -- KOG1889 Putative phosphoinositide phosphatase Cluster-8309.26598 BP_3 79.00 4.58 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01787 Ilarvirus coat protein GO:0006413 translational initiation GO:0003723 RNA binding GO:0019012 virion -- -- Cluster-8309.26599 BP_3 151.90 3.66 2292 642938614 XP_008199866.1 926 6.3e-97 PREDICTED: WAS protein family homolog 1 [Tribolium castaneum] -- -- -- -- -- K18461 WASH1 WAS protein family homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18461 A4IG59 527 4.8e-52 WAS protein family homolog 1 OS=Danio rerio GN=Wash1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.266 BP_3 3.00 0.64 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26600 BP_3 66.00 1.85 2011 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26601 BP_3 1.00 0.70 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26604 BP_3 71.36 0.73 5010 189238721 XP_970605.2 2192 2.2e-243 PREDICTED: collagen type IV alpha-3-binding protein isoform X1 [Tribolium castaneum]>gi|270010089|gb|EFA06537.1| hypothetical protein TcasGA2_TC009441 [Tribolium castaneum] 194753683 XM_001959104.1 36 2.2156e-06 Drosophila ananassae GF12210 (Dana\GF12210), mRNA K08283 COL4A3BP collagen type IV alpha-3-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08283 Q6VVX2 1273 3.3e-138 Collagen type IV alpha-3-binding protein OS=Cricetulus griseus GN=COL4A3BP PE=1 SV=1 PF01852 START domain -- -- GO:0005543//GO:0008289 phospholipid binding//lipid binding -- -- KOG1739 Serine/threonine protein kinase GPBP Cluster-8309.26605 BP_3 36.63 2.45 1012 546672885 ERL84608.1 887 9.2e-93 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 694 9.1e-72 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF08545//PF00108 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0006633//GO:0008152 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process//metabolic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.26606 BP_3 118.10 1.05 5723 642921136 XP_008192702.1 1068 5.4e-113 PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921138|ref|XP_008192703.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921140|ref|XP_008192704.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921142|ref|XP_008192706.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921144|ref|XP_008192707.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921146|ref|XP_008192708.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921148|ref|XP_008192709.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921150|ref|XP_008192710.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WVB4 224 1.6e-16 Slit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2 PF13855//PF13895//PF14991//PF15050 Leucine rich repeat//Immunoglobulin domain//Protein melan-A//SCIMP protein -- -- GO:0005515 protein binding GO:0042470//GO:0097197//GO:0016021//GO:0001772 melanosome//tetraspanin-enriched microdomain//integral component of membrane//immunological synapse -- -- Cluster-8309.26607 BP_3 1194.20 33.75 1997 478250939 ENN71423.1 362 1.4e-31 hypothetical protein YQE_11843, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V7U0 148 3.7e-08 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.26608 BP_3 216.61 2.98 3795 642918758 XP_008191571.1 825 5.3e-85 PREDICTED: ras association domain-containing protein 8 [Tribolium castaneum]>gi|270005673|gb|EFA02121.1| hypothetical protein TcasGA2_TC007768 [Tribolium castaneum] -- -- -- -- -- K09855 RASSF7_8 Ras association domain-containing protein 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K09855 Q8CJ96 306 3.3e-26 Ras association domain-containing protein 8 OS=Mus musculus GN=Rassf8 PE=2 SV=1 PF10186//PF00788//PF07851//PF10473 Vacuolar sorting 38 and autophagy-related subunit 14//Ras association (RalGDS/AF-6) domain//TMPIT-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0010508//GO:0007165 positive regulation of autophagy//signal transduction GO:0042803//GO:0008134//GO:0045502 protein homodimerization activity//transcription factor binding//dynein binding GO:0016021//GO:0030286//GO:0005667 integral component of membrane//dynein complex//transcription factor complex KOG1574 Predicted cell growth/differentiation regulator, contains RA domain Cluster-8309.26609 BP_3 191.81 2.92 3457 642918758 XP_008191571.1 1330 1.3e-143 PREDICTED: ras association domain-containing protein 8 [Tribolium castaneum]>gi|270005673|gb|EFA02121.1| hypothetical protein TcasGA2_TC007768 [Tribolium castaneum] -- -- -- -- -- K09855 RASSF7_8 Ras association domain-containing protein 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K09855 Q8CJ96 186 2.5e-12 Ras association domain-containing protein 8 OS=Mus musculus GN=Rassf8 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1574 Predicted cell growth/differentiation regulator, contains RA domain Cluster-8309.26610 BP_3 19.00 0.52 2052 642924686 XP_008194398.1 1528 8.8e-167 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD5 514 1.4e-50 Mitochondrial sodium/hydrogen exchanger 9B2 OS=Homo sapiens GN=SLC9B2 PE=1 SV=2 PF00999//PF09515//PF11770 Sodium/hydrogen exchanger family//Thiamine transporter protein (Thia_YuaJ)//GRB2-binding adapter (GAPT) GO:0015888//GO:0006812//GO:0006885//GO:0055085 thiamine transport//cation transport//regulation of pH//transmembrane transport GO:0015299//GO:0015234 solute:proton antiporter activity//thiamine transmembrane transporter activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.26616 BP_3 149.10 2.57 3088 549438529 AGX25153.1 1932 1.9e-213 sulfhydryl oxidase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q6AX23 834 1.6e-87 Sulfhydryl oxidase 2 OS=Xenopus laevis GN=qsox2 PE=2 SV=1 PF04777//PF00085 Erv1 / Alr family//Thioredoxin GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG1731 FAD-dependent sulfhydryl oxidase/quiescin and related proteins Cluster-8309.26617 BP_3 111.00 2.75 2239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26622 BP_3 11.92 0.32 2087 478259197 ENN79105.1 1285 1.3e-138 hypothetical protein YQE_04443, partial [Dendroctonus ponderosae] 642937798 XM_008202083.1 221 1.31876e-109 PREDICTED: Tribolium castaneum cleavage stimulation factor subunit 2 tau variant (LOC659353), mRNA K14407 CSTF2, RNA15 cleavage stimulation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14407 Q8HXM1 717 4.0e-74 Cleavage stimulation factor subunit 2 OS=Bos taurus GN=CSTF2 PE=2 SV=1 PF00076//PF16367//PF14304 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Transcription termination and cleavage factor C-terminal GO:0031124 mRNA 3'-end processing GO:0003676 nucleic acid binding -- -- KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15 Cluster-8309.26623 BP_3 19.22 1.21 1057 332372985 AEE61634.1 1287 4.0e-139 unknown [Dendroctonus ponderosae] 642937798 XM_008202083.1 221 6.57658e-110 PREDICTED: Tribolium castaneum cleavage stimulation factor subunit 2 tau variant (LOC659353), mRNA K14407 CSTF2, RNA15 cleavage stimulation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14407 Q8HXM1 717 2.0e-74 Cleavage stimulation factor subunit 2 OS=Bos taurus GN=CSTF2 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15 Cluster-8309.2663 BP_3 12.00 0.34 1983 546685307 ERL94834.1 747 3.1e-76 hypothetical protein D910_12107 [Dendroctonus ponderosae] -- -- -- -- -- K01059 LPL lipoprotein lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01059 Q8VBX1 467 3.7e-45 Endothelial lipase OS=Rattus norvegicus GN=Lipg PE=2 SV=2 PF02031//PF01764 Streptomyces extracellular neutral proteinase (M7) family//Lipase (class 3) GO:0006508//GO:0006629 proteolysis//lipid metabolic process GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0005576 extracellular region -- -- Cluster-8309.26633 BP_3 206.39 16.35 900 642922720 XP_008193296.1 744 3.1e-76 PREDICTED: LIM domain transcription factor LMO4.1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61968 471 5.8e-46 LIM domain transcription factor LMO4 OS=Homo sapiens GN=LMO4 PE=1 SV=1 PF01258//PF00412 Prokaryotic dksA/traR C4-type zinc finger//LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.26634 BP_3 51.94 6.21 695 642922720 XP_008193296.1 145 6.9e-07 PREDICTED: LIM domain transcription factor LMO4.1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05063 MT-A70 GO:0006139 nucleobase-containing compound metabolic process GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.26639 BP_3 116.36 2.49 2543 642932775 XP_008196978.1 1066 4.1e-113 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X2 [Tribolium castaneum] 642932786 XM_968738.3 205 1.26377e-100 PREDICTED: Tribolium castaneum dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (LOC662654), transcript variant X8, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 849 2.4e-89 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.26640 BP_3 163.78 2.88 3031 642932773 XP_008196977.1 3190 0.0e+00 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 759067243 XM_011344784.1 294 5.05559e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 6.2e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF13492//PF00233//PF01590//PF07533//PF13185 GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//BRK domain//GAF domain GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114//GO:0005515//GO:0016817 3',5'-cyclic-nucleotide phosphodiesterase activity//protein binding//hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.26641 BP_3 1.00 0.68 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26642 BP_3 527.74 9.47 2977 642932773 XP_008196977.1 1066 4.7e-113 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 642932786 XM_968738.3 205 1.48149e-100 PREDICTED: Tribolium castaneum dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (LOC662654), transcript variant X8, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 849 2.8e-89 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.26644 BP_3 17.16 0.39 2410 642932773 XP_008196977.1 3180 0.0e+00 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 759067243 XM_011344784.1 294 4.01028e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 4.9e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF13492//PF00233//PF01590//PF07533//PF13185 GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//BRK domain//GAF domain GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0005515//GO:0016817//GO:0004114 protein binding//hydrolase activity, acting on acid anhydrides//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.26647 BP_3 138.16 1.53 4642 546676723 ERL87679.1 1323 1.2e-142 hypothetical protein D910_05069 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24478 594 1.6e-59 Centrosome-associated zinc finger protein CP190 OS=Drosophila melanogaster GN=Cp190 PE=1 SV=2 PF00096//PF16622//PF00651 Zinc finger, C2H2 type//zinc-finger C2H2-type//BTB/POZ domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.2665 BP_3 105.00 7.36 979 478256362 ENN76552.1 270 3.1e-21 hypothetical protein YQE_07003, partial [Dendroctonus ponderosae]>gi|546680791|gb|ERL90997.1| hypothetical protein D910_08339 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.26650 BP_3 10.00 1.42 630 270015668 EFA12116.1 328 3.8e-28 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- K11162 RDH14 retinol dehydrogenase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11162 Q9HBH5 206 2.2e-15 Retinol dehydrogenase 14 OS=Homo sapiens GN=RDH14 PE=1 SV=1 PF00106//PF01733 short chain dehydrogenase//Nucleoside transporter GO:0015858//GO:0008152//GO:0006810 nucleoside transport//metabolic process//transport GO:0016491//GO:0005337 oxidoreductase activity//nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.26651 BP_3 19.54 0.42 2525 91077092 XP_970105.1 610 3.0e-60 PREDICTED: MYCBP-associated protein [Tribolium castaneum]>gi|270001731|gb|EEZ98178.1| hypothetical protein TcasGA2_TC000607 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q8UWA5 248 1.2e-19 Carbonic anhydrase 2 OS=Tribolodon hakonensis GN=ca2 PE=2 SV=3 PF01199 Ribosomal protein L34e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.26652 BP_3 12.80 3.89 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26654 BP_3 551.43 2.53 10795 642940144 XP_008200104.1 3309 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H269 1673 2.9e-184 Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens GN=VPS16 PE=1 SV=2 PF04841//PF04840 Vps16, N-terminal region//Vps16, C-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.26656 BP_3 1.00 0.93 336 478253725 ENN74024.1 165 1.6e-09 hypothetical protein YQE_09414, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03832 WSK motif GO:0006605//GO:0007165 protein targeting//signal transduction -- -- -- -- -- -- Cluster-8309.26657 BP_3 47.07 0.83 3041 270009008 EFA05456.1 2586 2.7e-289 hypothetical protein TcasGA2_TC015637 [Tribolium castaneum] 755951836 XM_011303587.1 50 2.20837e-14 PREDICTED: Fopius arisanus uncharacterized protein KIAA1109 (LOC105265834), transcript variant X9, mRNA -- -- -- -- A2AAE1 359 1.9e-32 Uncharacterized protein KIAA1109 OS=Mus musculus GN=Kiaa1109 PE=1 SV=4 PF08093 Magi 5 toxic peptide family GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.26660 BP_3 686.80 26.73 1530 91089889 XP_966960.1 1779 5.1e-196 PREDICTED: actin-like protein 6B [Tribolium castaneum]>gi|270013557|gb|EFA10005.1| hypothetical protein TcasGA2_TC012175 [Tribolium castaneum] 676438341 XM_009050250.1 51 3.05568e-15 Lottia gigantea hypothetical protein mRNA K11652 ACTL6B actin-like protein 6B http://www.genome.jp/dbget-bin/www_bget?ko:K11652 P86173 1118 9.4e-121 Actin-like protein 6B OS=Rattus norvegicus GN=Actl6b PE=1 SV=2 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0679 Actin-related protein - Arp4p/Act3p Cluster-8309.26662 BP_3 395.70 9.18 2370 270004866 EFA01314.1 634 4.7e-63 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 473 9.0e-46 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26663 BP_3 574.92 6.72 4414 332376575 AEE63427.1 1298 8.8e-140 unknown [Dendroctonus ponderosae]>gi|546673735|gb|ERL85291.1| hypothetical protein D910_02712 [Dendroctonus ponderosae] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q5FWL7 827 1.5e-86 Palmitoyltransferase ZDHHC15 OS=Xenopus laevis GN=zdhhc15 PE=2 SV=1 PF00219//PF01529//PF02714//PF01309 Insulin-like growth factor binding protein//DHHC palmitoyltransferase//Calcium-dependent channel, 7TM region, putative phosphate//Equine arteritis virus small envelope glycoprotein GO:0001558 regulation of cell growth GO:0005520//GO:0008270 insulin-like growth factor binding//zinc ion binding GO:0005576//GO:0016020//GO:0019031//GO:0016942 extracellular region//membrane//viral envelope//insulin-like growth factor binding protein complex KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.26664 BP_3 2.00 0.36 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26667 BP_3 117.30 1.43 4253 642935245 XP_008197928.1 4434 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 727 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1745 5.1e-193 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF16656//PF13895//PF00041//PF05506 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain//Domain of unknown function (DUF756) GO:0016042//GO:0006771//GO:0009395//GO:0019497 lipid catabolic process//riboflavin metabolic process//phospholipid catabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0004629//GO:0005515 acid phosphatase activity//metal ion binding//phospholipase C activity//protein binding -- -- -- -- Cluster-8309.26670 BP_3 716.00 6.20 5854 91094283 XP_970886.1 3594 0.0e+00 PREDICTED: BTB/POZ domain-containing protein 7 [Tribolium castaneum]>gi|270014398|gb|EFA10846.1| hypothetical protein TcasGA2_TC001623 [Tribolium castaneum] -- -- -- -- -- K10479 BTBD7 BTB/POZ domain-containing protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10479 Q9P203 1428 4.1e-156 BTB/POZ domain-containing protein 7 OS=Homo sapiens GN=BTBD7 PE=1 SV=3 PF07127//PF00651 Late nodulin protein//BTB/POZ domain GO:0009878 nodule morphogenesis GO:0005515//GO:0046872 protein binding//metal ion binding -- -- KOG2838 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.26672 BP_3 913.00 34.48 1568 91078056 XP_971325.1 1674 7.9e-184 PREDICTED: endoplasmic reticulum lectin 1 [Tribolium castaneum]>gi|270001404|gb|EEZ97851.1| hypothetical protein TcasGA2_TC000223 [Tribolium castaneum] -- -- -- -- -- K14008 ERLEC1, XTP3B endoplasmic reticulum lectin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14008 Q5R8S4 957 4.5e-102 Endoplasmic reticulum lectin 1 OS=Pongo abelii GN=ERLEC1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3394 Protein OS-9 Cluster-8309.26673 BP_3 26.39 0.89 1721 270010103 EFA06551.1 421 1.7e-38 hypothetical protein TcasGA2_TC009460 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5HZY0 235 2.6e-18 UBX domain-containing protein 4 OS=Rattus norvegicus GN=Ubxn4 PE=2 SV=1 PF05279//PF00789//PF05602 Aspartyl beta-hydroxylase N-terminal region//UBX domain//Cleft lip and palate transmembrane protein 1 (CLPTM1) -- -- GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains Cluster-8309.26674 BP_3 7.00 0.43 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26675 BP_3 33.00 1.77 1190 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26679 BP_3 2.00 51.99 220 768410654 XP_011559576.1 236 6.1e-18 PREDICTED: embryonic polarity protein dorsal-like isoform X1 [Plutella xylostella] -- -- -- -- -- K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 206 7.6e-16 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.2668 BP_3 63.10 0.83 3963 270015509 EFA11957.1 1503 1.3e-163 serine protease H82 [Tribolium castaneum] 641658676 XM_001951259.3 168 7.31897e-80 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- P03952 447 1.6e-42 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.26682 BP_3 2415.82 30.30 4135 642938616 XP_008199867.1 2131 2.1e-236 PREDICTED: epidermal growth factor receptor kinase substrate 8 [Tribolium castaneum] -- -- -- -- -- K17277 EPS8 epidermal growth factor receptor kinase substrate 8 http://www.genome.jp/dbget-bin/www_bget?ko:K17277 Q9H6S3 571 6.8e-57 Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Homo sapiens GN=EPS8L2 PE=1 SV=2 PF00536//PF08416//PF14604//PF00018//PF02198 SAM domain (Sterile alpha motif)//Phosphotyrosine-binding domain//Variant SH3 domain//SH3 domain//Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus KOG3557 Epidermal growth factor receptor kinase substrate Cluster-8309.26684 BP_3 175.89 12.57 966 91077764 XP_968340.1 874 2.8e-91 PREDICTED: semaphorin-2A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XZC8 664 2.6e-68 Semaphorin-2A OS=Schistocerca gregaria GN=SEMA-2A PE=2 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26687 BP_3 27.81 0.36 3991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26688 BP_3 36.19 0.55 3453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26689 BP_3 51.24 0.99 2783 189236857 XP_974302.2 1085 2.8e-115 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum] 541975047 XM_005440594.1 35 4.40089e-06 PREDICTED: Falco cherrug solute carrier family 36 (proton/amino acid symporter), member 1 (SLC36A1), mRNA K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 435 2.7e-41 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26693 BP_3 835.79 44.21 1203 91092692 XP_971829.1 397 7.2e-36 PREDICTED: uncharacterized protein LOC660509 [Tribolium castaneum]>gi|642911393|ref|XP_008199405.1| PREDICTED: uncharacterized protein LOC660509 [Tribolium castaneum]>gi|270015139|gb|EFA11587.1| immune deficiency [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00531//PF10541 Death domain//Nuclear envelope localisation domain GO:0007165 signal transduction GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.26695 BP_3 45.60 1.28 2007 270010378 EFA06826.1 2294 1.3e-255 hypothetical protein TcasGA2_TC009768 [Tribolium castaneum] 642928761 XM_008201551.1 641 0 PREDICTED: Tribolium castaneum nephrin (LOC663236), mRNA -- -- -- -- Q9R044 217 3.7e-16 Nephrin OS=Rattus norvegicus GN=Nphs1 PE=1 SV=2 PF04850//PF00041//PF13895 Baculovirus E66 occlusion-derived virus envelope protein//Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules Cluster-8309.26698 BP_3 319.25 3.89 4248 642938759 XP_008199876.1 658 1.4e-65 PREDICTED: protein transport protein Sec16B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2670 BP_3 12.00 0.92 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26700 BP_3 45.38 0.77 3120 282165752 NP_001164117.1 1262 9.3e-136 uncharacterized protein LOC100322888 [Tribolium castaneum]>gi|270013327|gb|EFA09775.1| hypothetical protein TcasGA2_TC011917 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26701 BP_3 12.10 0.47 1543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26703 BP_3 404.00 16.31 1486 91078538 XP_970648.1 1187 2.2e-127 PREDICTED: FIT family protein CG10671 [Tribolium castaneum]>gi|270003835|gb|EFA00283.1| hypothetical protein TcasGA2_TC003116 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRJ2 826 6.6e-87 FIT family protein CG10671 OS=Drosophila melanogaster GN=CG10671 PE=1 SV=1 PF10261 Inositol phospholipid synthesis and fat-storage-inducing TM GO:0019915 lipid storage -- -- GO:0005789 endoplasmic reticulum membrane KOG3750 Inositol phospholipid synthesis protein, Scs3p Cluster-8309.26704 BP_3 26.21 7.91 451 332376915 AEE63597.1 286 2.0e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02956 RP-S15, MRPS15, rpsO small subunit ribosomal protein S15 http://www.genome.jp/dbget-bin/www_bget?ko:K02956 Q8WTC1 224 1.3e-17 28S ribosomal protein S15, mitochondrial OS=Drosophila melanogaster GN=bonsai PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26705 BP_3 2.00 0.58 458 478261416 ENN80793.1 162 4.9e-09 hypothetical protein YQE_02802, partial [Dendroctonus ponderosae]>gi|546680989|gb|ERL91163.1| hypothetical protein D910_08503 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- -- -- Cluster-8309.26706 BP_3 28.00 5.16 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26708 BP_3 597.02 7.15 4319 642934390 XP_008197640.1 2987 0.0e+00 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Tribolium castaneum] 462277993 APGK01058794.1 35 6.86167e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 1000 1.3e-106 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF00620//PF01553 RhoGAP domain//Acyltransferase GO:0008152//GO:0007165 metabolic process//signal transduction GO:0016746 transferase activity, transferring acyl groups -- -- KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.26709 BP_3 41.68 0.49 4429 642934390 XP_008197640.1 2987 0.0e+00 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Tribolium castaneum] 462277993 APGK01058794.1 35 7.0379e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 1000 1.3e-106 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553//PF00620 Acyltransferase//RhoGAP domain GO:0007165//GO:0008152 signal transduction//metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.2671 BP_3 3.00 0.36 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26711 BP_3 149.79 2.92 2762 805816622 XP_003706959.2 1006 4.0e-106 PREDICTED: DNA-(apurinic or apyrimidinic site) lyase isoform X1 [Megachile rotundata] -- -- -- -- -- K10771 APEX1 AP endonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10771 P27864 853 9.1e-90 Recombination repair protein 1 OS=Drosophila melanogaster GN=Rrp1 PE=1 SV=2 PF10392//PF02214 Golgi transport complex subunit 5//BTB/POZ domain GO:0006891//GO:0051260 intra-Golgi vesicle-mediated transport//protein homooligomerization -- -- GO:0017119 Golgi transport complex KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes Cluster-8309.26714 BP_3 3680.82 83.09 2427 642930397 XP_008196382.1 1651 5.7e-181 PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930399|ref|XP_008196383.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930401|ref|XP_008196384.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|270010720|gb|EFA07168.1| hypothetical protein TcasGA2_TC010167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7JUY7 659 2.5e-67 PTB domain-containing adapter protein ced-6 OS=Drosophila melanogaster GN=ced-6 PE=1 SV=1 PF14719//PF00640//PF08416 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG3536 Adaptor protein CED-6, contains PTB domain Cluster-8309.26715 BP_3 10.10 0.48 1311 642930397 XP_008196382.1 245 3.3e-18 PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930399|ref|XP_008196383.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930401|ref|XP_008196384.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|270010720|gb|EFA07168.1| hypothetical protein TcasGA2_TC010167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26716 BP_3 276.48 1.31 10472 642911353 XP_008199386.1 4646 0.0e+00 PREDICTED: uncharacterized protein LOC659886 isoform X3 [Tribolium castaneum] 642911358 XM_008201167.1 137 3.32315e-62 PREDICTED: Tribolium castaneum uncharacterized LOC659886 (LOC659886), transcript variant X6, mRNA -- -- -- -- B6RSP1 355 1.9e-31 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 PF14978 Mitochondrial ribosome protein 63 -- -- -- -- GO:0005761 mitochondrial ribosome -- -- Cluster-8309.26717 BP_3 525.00 9.30 3014 817080920 XP_012262945.1 3395 0.0e+00 PREDICTED: DNA excision repair protein haywire [Athalia rosae] 242005968 XM_002423787.1 471 0 Pediculus humanus corporis DNA excision repair protein haywire, putative, mRNA K10843 ERCC3, XPB DNA excision repair protein ERCC-3 http://www.genome.jp/dbget-bin/www_bget?ko:K10843 Q02870 3254 0.0e+00 DNA excision repair protein haywire OS=Drosophila melanogaster GN=hay PE=1 SV=2 PF00270//PF00176//PF04851 DEAD/DEAH box helicase//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3'-5' helicase subunit SSL2 Cluster-8309.26718 BP_3 12.47 3.48 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26719 BP_3 506.89 6.46 4074 270297184 NP_001161900.1 672 3.2e-67 cuticular protein analogous to peritrophins 1-I precursor [Tribolium castaneum]>gi|268373732|gb|ACZ04319.1| CPAP1-I [Tribolium castaneum]>gi|270014341|gb|EFA10789.1| hypothetical protein TcasGA2_TC012766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05412 Equine arterivirus Nsp2-type cysteine proteinase GO:0016032//GO:0019082 viral process//viral protein processing -- -- -- -- -- -- Cluster-8309.26720 BP_3 16.00 1.87 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02902 Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- -- -- Cluster-8309.26721 BP_3 149.49 2.01 3869 642938137 XP_008199781.1 1838 1.9e-202 PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|642938140|ref|XP_008199782.1| PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|270016485|gb|EFA12931.1| hypothetical protein TcasGA2_TC010477 [Tribolium castaneum] 194750862 XM_001957713.1 248 2.41087e-124 Drosophila ananassae GF10569 (Dana\GF10569), mRNA K08827 PRPF4B serine/threonine-protein kinase PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K08827 Q13523 1338 7.3e-146 Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens GN=PRPF4B PE=1 SV=3 PF05445//PF07714//PF00069 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0670 U4/U6-associated splicing factor PRP4 Cluster-8309.26725 BP_3 5.26 0.41 914 478252006 ENN72441.1 205 1.0e-13 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- -- -- Cluster-8309.26726 BP_3 12.60 0.36 1973 642919569 XP_008191926.1 617 3.7e-61 PREDICTED: protein angel homolog 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q8VCU0 395 8.3e-37 Protein angel homolog 1 OS=Mus musculus GN=Angel1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.26727 BP_3 71.00 2.38 1731 642938732 XP_966846.2 813 6.0e-84 PREDICTED: methionine synthase reductase [Tribolium castaneum] -- -- -- -- -- K00597 MTRR methionine synthase reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00597 Q498R1 684 2.2e-70 Methionine synthase reductase OS=Rattus norvegicus GN=Mtrr PE=2 SV=2 PF00175//PF08030//PF00667 Oxidoreductase NAD-binding domain//Ferric reductase NAD binding domain//FAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.26728 BP_3 131.93 5.45 1458 478250608 ENN71100.1 1368 2.2e-148 hypothetical protein YQE_12033, partial [Dendroctonus ponderosae] -- -- -- -- -- K02328 POLD2 DNA polymerase delta subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02328 Q9W088 829 2.9e-87 DNA polymerase delta small subunit OS=Drosophila melanogaster GN=CG12018 PE=2 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG2732 DNA polymerase delta, regulatory subunit 55 Cluster-8309.26729 BP_3 7.00 0.86 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26731 BP_3 2517.77 40.91 3258 642932825 XP_008197001.1 2058 4.9e-228 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 1083 2.3e-116 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019//PF00957 Gamma-glutamyltranspeptidase//Synaptobrevin GO:0006693//GO:0006749//GO:0006691//GO:0019530//GO:0016192 prostaglandin metabolic process//glutathione metabolic process//leukotriene metabolic process//taurine metabolic process//vesicle-mediated transport GO:0003840 gamma-glutamyltransferase activity GO:0016021 integral component of membrane KOG2410 Gamma-glutamyltransferase Cluster-8309.26732 BP_3 371.64 5.60 3491 91089189 XP_974407.1 2024 4.6e-224 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 1083 2.4e-116 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019 Gamma-glutamyltranspeptidase GO:0019530//GO:0006691//GO:0006749//GO:0006693 taurine metabolic process//leukotriene metabolic process//glutathione metabolic process//prostaglandin metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.26735 BP_3 496.18 9.11 2916 546682502 ERL92425.1 1115 9.7e-119 hypothetical protein D910_09739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3T8J9 203 2.3e-14 GON-4-like protein OS=Homo sapiens GN=GON4L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26736 BP_3 4.36 0.51 708 270015041 EFA11489.1 391 2.1e-35 hypothetical protein TcasGA2_TC014202 [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 Q9V9S8 357 7.6e-33 Ferrochelatase, mitochondrial OS=Drosophila melanogaster GN=FeCh PE=2 SV=1 PF09117//PF00762 MiAMP1//Ferrochelatase GO:0015994//GO:0006783//GO:0006952//GO:0045926 chlorophyll metabolic process//heme biosynthetic process//defense response//negative regulation of growth GO:0004325 ferrochelatase activity -- -- KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26737 BP_3 21.65 2.23 759 478256641 ENN76823.1 351 9.8e-31 hypothetical protein YQE_06664, partial [Dendroctonus ponderosae]>gi|546685160|gb|ERL94687.1| hypothetical protein D910_11962 [Dendroctonus ponderosae] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 P22315 290 4.8e-25 Ferrochelatase, mitochondrial OS=Mus musculus GN=Fech PE=1 SV=2 PF00762 Ferrochelatase GO:0006783//GO:0015994 heme biosynthetic process//chlorophyll metabolic process GO:0004325 ferrochelatase activity -- -- KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26738 BP_3 505.99 32.95 1032 642910800 XP_008193416.1 984 5.3e-104 PREDICTED: ferrochelatase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 Q9V9S8 824 7.8e-87 Ferrochelatase, mitochondrial OS=Drosophila melanogaster GN=FeCh PE=2 SV=1 PF09117//PF00762 MiAMP1//Ferrochelatase GO:0045926//GO:0015994//GO:0006952//GO:0006783 negative regulation of growth//chlorophyll metabolic process//defense response//heme biosynthetic process GO:0004325 ferrochelatase activity -- -- KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26739 BP_3 439.29 2.00 10888 270000947 EEZ97394.1 648 5.1e-64 hypothetical protein TcasGA2_TC011220 [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 P10394 426 1.2e-39 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF13639//PF02861//PF01105//PF06988//PF04108//PF00762//PF08651//PF00209//PF05791 Ring finger domain//Clp amino terminal domain, pathogenicity island component//emp24/gp25L/p24 family/GOLD//NifT/FixU protein//Autophagy protein Apg17//Ferrochelatase//DASH complex subunit Duo1//Sodium:neurotransmitter symporter family//Bacillus haemolytic enterotoxin (HBL) GO:0006836//GO:0015994//GO:0006783//GO:0009399//GO:0009405//GO:0006810//GO:0006914//GO:0007067//GO:0006812//GO:0019538 neurotransmitter transport//chlorophyll metabolic process//heme biosynthetic process//nitrogen fixation//pathogenesis//transport//autophagy//mitotic nuclear division//cation transport//protein metabolic process GO:0004325//GO:0005515//GO:0005328//GO:0008270 ferrochelatase activity//protein binding//neurotransmitter:sodium symporter activity//zinc ion binding GO:0072686//GO:0016020//GO:0016021//GO:0042729 mitotic spindle//membrane//integral component of membrane//DASH complex KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.2674 BP_3 157.25 40.63 478 546672298 ERL84225.1 356 1.6e-31 hypothetical protein D910_01603 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 240 1.9e-19 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.26740 BP_3 230.00 3.96 3091 91076270 XP_967714.1 583 5.0e-57 PREDICTED: uncharacterized protein LOC656069 [Tribolium castaneum]>gi|270002519|gb|EEZ98966.1| hypothetical protein TcasGA2_TC004821 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26741 BP_3 492.62 2.24 10903 270000947 EEZ97394.1 627 1.4e-61 hypothetical protein TcasGA2_TC011220 [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 P10394 439 3.6e-41 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF05791//PF00209//PF06009//PF00762//PF08651//PF04108//PF06988//PF10044//PF01105//PF13639 Bacillus haemolytic enterotoxin (HBL)//Sodium:neurotransmitter symporter family//Laminin Domain II//Ferrochelatase//DASH complex subunit Duo1//Autophagy protein Apg17//NifT/FixU protein//Retinal tissue protein//emp24/gp25L/p24 family/GOLD//Ring finger domain GO:0006351//GO:0006836//GO:0015994//GO:0007155//GO:0006783//GO:0009399//GO:0009405//GO:0006914//GO:0006810//GO:0007067//GO:0006812//GO:0007049 transcription, DNA-templated//neurotransmitter transport//chlorophyll metabolic process//cell adhesion//heme biosynthetic process//nitrogen fixation//pathogenesis//autophagy//transport//mitotic nuclear division//cation transport//cell cycle GO:0004325//GO:0005515//GO:0005328//GO:0008270 ferrochelatase activity//protein binding//neurotransmitter:sodium symporter activity//zinc ion binding GO:0072686//GO:0016020//GO:0070176//GO:0016021//GO:0042729 mitotic spindle//membrane//DRM complex//integral component of membrane//DASH complex KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26743 BP_3 2480.36 89.53 1627 189237343 XP_001813445.1 1160 3.3e-124 PREDICTED: uncharacterized protein LOC100142172 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26744 BP_3 3.00 2.31 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26745 BP_3 10.70 0.59 1171 91079286 XP_972784.1 634 2.3e-63 PREDICTED: syntaxin-17 [Tribolium castaneum]>gi|270004314|gb|EFA00762.1| hypothetical protein TcasGA2_TC003648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D0I4 166 1.8e-10 Syntaxin-17 OS=Mus musculus GN=Stx17 PE=1 SV=1 PF04728//PF05531//PF06009//PF05739//PF00804//PF00816//PF03462 Lipoprotein leucine-zipper//Nucleopolyhedrovirus P10 protein//Laminin Domain II//SNARE domain//Syntaxin//H-NS histone family//PCRF domain GO:0006415//GO:0006355//GO:0007155//GO:0006449 translational termination//regulation of transcription, DNA-templated//cell adhesion//regulation of translational termination GO:0003677//GO:0016149//GO:0005515 DNA binding//translation release factor activity, codon specific//protein binding GO:0005622//GO:0016020//GO:0005840//GO:0005737//GO:0018444//GO:0019867//GO:0019028 intracellular//membrane//ribosome//cytoplasm//translation release factor complex//outer membrane//viral capsid -- -- Cluster-8309.26746 BP_3 46.76 594.06 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26747 BP_3 14.69 0.80 1180 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03694 Erg28 like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26748 BP_3 348.86 3.15 5635 642914535 XP_008201718.1 2050 7.1e-227 PREDICTED: Hermansky-Pudlak syndrome 1 protein homolog isoform X1 [Tribolium castaneum] 701432439 XM_010006117.1 50 4.1147e-14 PREDICTED: Chaetura pelagica kelch-like family member 5 (KLHL5), transcript variant X3, mRNA K10442 KLHL1_4_5 kelch-like protein 1/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10442 Q96PQ7 872 1.2e-91 Kelch-like protein 5 OS=Homo sapiens GN=KLHL5 PE=2 SV=3 PF07646//PF00651//PF10576//PF01344//PF03931 Kelch motif//BTB/POZ domain//Iron-sulfur binding domain of endonuclease III//Kelch motif//Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0051539//GO:0005515 4 iron, 4 sulfur cluster binding//protein binding -- -- -- -- Cluster-8309.26752 BP_3 20.00 0.33 3203 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26753 BP_3 458.14 14.01 1868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26755 BP_3 1154.52 10.87 5411 642936846 XP_008197874.1 4246 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase listerin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1C231 1009 1.4e-107 E3 ubiquitin-protein ligase listerin OS=Gallus gallus GN=LTN1 PE=3 SV=1 PF12861//PF13639//PF00097//PF12906//PF12678//PF00628//PF05225//PF07022//PF00130 Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//RING-variant domain//RING-H2 zinc finger//PHD-finger//helix-turn-helix, Psq domain//Bacteriophage CI repressor helix-turn-helix domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0016567//GO:0045892//GO:0035556 protein ubiquitination//negative regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0005515//GO:0004842//GO:0008270//GO:0046872 DNA binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding//metal ion binding GO:0005680 anaphase-promoting complex KOG0803 Predicted E3 ubiquitin ligase Cluster-8309.26756 BP_3 3802.48 50.44 3925 642916707 XP_008192271.1 5016 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0C6B8 862 1.2e-90 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus GN=Svep1 PE=1 SV=1 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.26758 BP_3 514.28 13.43 2137 91089541 XP_971419.1 817 2.5e-84 PREDICTED: protein canopy 4 [Tribolium castaneum]>gi|270012595|gb|EFA09043.1| hypothetical protein TcasGA2_TC006756 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2L6K8 521 2.2e-51 Protein canopy 4 OS=Danio rerio GN=cnpy4 PE=2 SV=1 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- KOG4052 Uncharacterized conserved protein Cluster-8309.26760 BP_3 216.23 5.22 2289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26762 BP_3 1002.00 37.14 1592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26763 BP_3 11.00 0.65 1105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26765 BP_3 2.00 16.77 248 642918391 XP_008200125.1 384 4.7e-35 PREDICTED: zinc finger protein 271-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF02892//PF02184//PF05191//PF16622//PF13465//PF00096 C2H2-type zinc finger//BED zinc finger//HAT (Half-A-TPR) repeat//Adenylate kinase, active site lid//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type GO:0046034//GO:0006144//GO:0006396 ATP metabolic process//purine nucleobase metabolic process//RNA processing GO:0004017//GO:0046872//GO:0003677 adenylate kinase activity//metal ion binding//DNA binding GO:0005622 intracellular -- -- Cluster-8309.26766 BP_3 22.00 2.24 765 571524111 XP_006562788.1 196 9.3e-13 PREDICTED: uncharacterized protein LOC724604 [Apis mellifera] 642918390 XM_008201903.1 49 1.93337e-14 PREDICTED: Tribolium castaneum zinc finger protein 271-like (LOC656007), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P52737 174 1.4e-11 Zinc finger protein 136 OS=Homo sapiens GN=ZNF136 PE=1 SV=1 PF00096//PF13465//PF15926//PF01780//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//E3 ubiquitin-protein ligase RNF220//Ribosomal L37ae protein family//BED zinc finger//C2H2-type zinc finger GO:0016567//GO:0006412//GO:0090263//GO:0042254 protein ubiquitination//translation//positive regulation of canonical Wnt signaling pathway//ribosome biogenesis GO:0003677//GO:0046872//GO:0003735 DNA binding//metal ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.26769 BP_3 36.15 0.38 4857 478257240 ENN77403.1 2157 2.4e-239 hypothetical protein YQE_06228, partial [Dendroctonus ponderosae] 768451728 XM_011569773.1 111 4.36166e-48 PREDICTED: Plutella xylostella GTPase-activating protein-like (LOC105397755), partial mRNA K12380 RASA3 Ras GTPase-activating protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12380 P48423 1378 2.1e-150 GTPase-activating protein OS=Drosophila melanogaster GN=RasGAP1 PE=1 SV=2 PF00779//PF00616//PF00168 BTK motif//GTPase-activator protein for Ras-like GTPase//C2 domain GO:0043087//GO:0035556 regulation of GTPase activity//intracellular signal transduction GO:0005515 protein binding -- -- KOG2059 Ras GTPase-activating protein Cluster-8309.26771 BP_3 134.68 2.31 3096 270005705 EFA02153.1 451 1.0e-41 hypothetical protein TcasGA2_TC007806 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26772 BP_3 25.02 0.83 1752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26773 BP_3 50.72 1.04 2648 642912820 XP_008201266.1 496 5.3e-47 PREDICTED: DNA damage-regulated autophagy modulator protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC48 289 2.2e-24 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 PF01825 GPCR proteolysis site, GPS, motif -- -- -- -- GO:0016020 membrane KOG4320 Uncharacterized conserved protein Cluster-8309.26775 BP_3 16.40 0.52 1818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26777 BP_3 11.15 0.33 1901 189238926 XP_001811313.1 607 5.1e-60 PREDICTED: acyl-CoA-binding domain-containing protein 5A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641E3 295 3.2e-25 Acyl-CoA-binding domain-containing protein 5 OS=Xenopus laevis GN=acbd5 PE=2 SV=1 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-8309.26779 BP_3 54.40 1.56 1973 642919618 XP_008191942.1 572 6.0e-56 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] 642919617 XM_008193720.1 76 5.01646e-29 PREDICTED: Tribolium castaneum protein kinase C and casein kinase substrate in neurons protein 1 (LOC103312632), mRNA -- -- -- -- Q9DDA9 294 4.3e-25 Protein kinase C and casein kinase substrate in neurons protein 2 OS=Xenopus laevis GN=pacsin2 PE=2 SV=1 PF15460//PF01786 Something about silencing, SAS, complex subunit 4//Alternative oxidase GO:0016573//GO:0006118//GO:0055114 histone acetylation//obsolete electron transport//oxidation-reduction process GO:0009916 alternative oxidase activity -- -- KOG2856 Adaptor protein PACSIN Cluster-8309.26782 BP_3 30.00 0.32 4757 572315406 XP_006623355.1 3836 0.0e+00 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit-like isoform X2 [Apis dorsata] 262305002 GQ887521.1 543 0 Libinia emarginata voucher LemMALA acetylglucosaminyl-transferase mRNA, partial cds K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 Q8CGY8 3511 0.0e+00 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Mus musculus GN=Ogt PE=1 SV=2 PF13414//PF13176//PF00857//PF13371//PF00515//PF13374//PF02259//PF13174//PF13181 TPR repeat//Tetratricopeptide repeat//Isochorismatase family//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0008152 metabolic process GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.26784 BP_3 20.00 0.67 1741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26785 BP_3 31.00 2.75 836 184198734 ACC76803.1 697 8.2e-71 Lit v 3 allergen myosin light chain [Litopenaeus vannamei] 184198733 EU449515.1 263 2.31541e-133 Litopenaeus vannamei Lit v 3 allergen myosin light chain mRNA, complete cds K10351 MYL2 myosin regulatory light chain 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10351 Q1HPS0 502 1.4e-49 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF01342//PF13499//PF13833//PF13405//PF00036//PF13202 SAND domain//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//EF hand -- -- GO:0005509//GO:0003677 calcium ion binding//DNA binding -- -- -- -- Cluster-8309.26787 BP_3 387.16 3.61 5467 91086191 XP_971352.1 1528 2.3e-166 PREDICTED: WD repeat-containing protein 92 [Tribolium castaneum]>gi|270010235|gb|EFA06683.1| hypothetical protein TcasGA2_TC009613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29RZ9 1178 3.7e-127 WD repeat-containing protein 92 OS=Bos taurus GN=WDR92 PE=2 SV=1 PF00400//PF02391//PF10741 WD domain, G-beta repeat//MoaE protein//Type II secretion system (T2SS), protein M subtype b GO:0006858//GO:0006777 extracellular transport//Mo-molybdopterin cofactor biosynthetic process GO:0005515 protein binding -- -- KOG3307 Molybdopterin converting factor subunit 2 Cluster-8309.26789 BP_3 38.88 1.31 1720 642919693 XP_008192024.1 389 8.7e-35 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- K06694 PSMD10 26S proteasome non-ATPase regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06694 Q108T9 210 2.0e-15 Cortactin-binding protein 2 OS=Loxodonta africana GN=CTTNBP2 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.2679 BP_3 6.43 0.37 1135 270004639 EFA01087.1 375 2.4e-33 hypothetical protein TcasGA2_TC004010 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V7U0 166 1.7e-10 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.26794 BP_3 18.25 0.87 1306 189240985 XP_001808932.1 867 2.5e-90 PREDICTED: probable cytosolic Fe-S cluster assembly factor CPIJ010948 [Tribolium castaneum]>gi|270012992|gb|EFA09440.1| hypothetical protein TcasGA2_TC010652 [Tribolium castaneum] 462325677 APGK01041744.1 51 2.59784e-15 Dendroctonus ponderosae Seq01041754, whole genome shotgun sequence -- -- -- -- B4MUM8 561 3.1e-56 Probable cytosolic Fe-S cluster assembly factor GK14772 OS=Drosophila willistoni GN=GK14772 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2439 Nuclear architecture related protein Cluster-8309.26795 BP_3 448.77 3.17 7107 642916946 XP_008199566.1 487 1.6e-45 PREDICTED: FGFR1 oncogene partner [Tribolium castaneum] 242023379 XM_002432067.1 93 6.48549e-38 Pediculus humanus corporis mitochondrial import inner membrane translocase subunit TIM13, putative, mRNA K17781 TIM13 mitochondrial import inner membrane translocase subunit TIM13 http://www.genome.jp/dbget-bin/www_bget?ko:K17781 Q8AVK1 314 7.4e-27 Mitochondrial import inner membrane translocase subunit Tim13-B OS=Xenopus laevis GN=timm13-b PE=3 SV=1 PF09398//PF01468//PF16045 FOP N terminal dimerisation domain//GA module//LisH GO:0009405//GO:0034453 pathogenesis//microtubule anchoring GO:0005515 protein binding GO:0005815 microtubule organizing center KOG1733 Mitochondrial import inner membrane translocase, subunit TIM13 Cluster-8309.26796 BP_3 22.00 2.65 692 642099317 CDQ77565.1 170 8.7e-10 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26798 BP_3 10.19 0.71 982 270010105 EFA06553.1 766 9.6e-79 hypothetical protein TcasGA2_TC009462 [Tribolium castaneum] -- -- -- -- -- K07890 RAB21 Ras-related protein Rab-21 http://www.genome.jp/dbget-bin/www_bget?ko:K07890 P55745 356 1.4e-32 Ras-related protein Rab-21 OS=Canis familiaris GN=RAB21 PE=3 SV=3 PF08477//PF00071//PF00025//PF04042 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family//DNA polymerase alpha/epsilon subunit B GO:0007264//GO:0006260 small GTPase mediated signal transduction//DNA replication GO:0003887//GO:0003677//GO:0005525 DNA-directed DNA polymerase activity//DNA binding//GTP binding GO:0042575 DNA polymerase complex KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.26799 BP_3 315.78 19.46 1074 91085709 XP_972846.1 843 1.2e-87 PREDICTED: ras-related protein RABF2b [Tribolium castaneum] -- -- -- -- -- K07890 RAB21 Ras-related protein Rab-21 http://www.genome.jp/dbget-bin/www_bget?ko:K07890 P55745 383 1.1e-35 Ras-related protein Rab-21 OS=Canis familiaris GN=RAB21 PE=3 SV=3 PF04670//PF00025//PF00071//PF01637//PF01926//PF03193//PF08477 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//Archaeal ATPase//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.268 BP_3 3.00 0.53 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26803 BP_3 271.00 5.66 2600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26806 BP_3 94.30 1.28 3848 270014679 EFA11127.1 546 1.2e-52 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 256 2.1e-20 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26807 BP_3 338.07 13.91 1463 91079170 XP_967650.1 875 3.3e-91 PREDICTED: viral IAP-associated factor homolog [Tribolium castaneum]>gi|270004241|gb|EFA00689.1| hypothetical protein TcasGA2_TC003566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MR62 659 1.5e-67 Viral IAP-associated factor homolog OS=Drosophila melanogaster GN=viaf PE=1 SV=1 PF00445//PF04104 Ribonuclease T2 family//Eukaryotic and archaeal DNA primase, large subunit GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0033897//GO:0003896//GO:0003723 ribonuclease T2 activity//DNA primase activity//RNA binding GO:0005730//GO:0005657 nucleolus//replication fork KOG3170 Conserved phosducin-like protein Cluster-8309.26809 BP_3 22.00 0.44 2682 498940560 XP_004521425.1 2559 3.2e-286 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [Ceratitis capitata] 827557300 XM_012694468.1 426 0 PREDICTED: Bombyx mori putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (LOC101743469), mRNA K12813 DHX16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 http://www.genome.jp/dbget-bin/www_bget?ko:K12813 Q767K6 2083 2.1e-232 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Sus scrofa GN=DHX16 PE=3 SV=1 PF14532//PF04408//PF00437//PF07652//PF00270//PF00448 Sigma-54 interaction domain//Helicase associated domain (HA2)//Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase//SRP54-type protein, GTPase domain GO:0006810//GO:0006614//GO:0019079//GO:0006355 transport//SRP-dependent cotranslational protein targeting to membrane//viral genome replication//regulation of transcription, DNA-templated GO:0008026//GO:0008134//GO:0004386//GO:0005524//GO:0005525//GO:0003676 ATP-dependent helicase activity//transcription factor binding//helicase activity//ATP binding//GTP binding//nucleic acid binding GO:0005667 transcription factor complex KOG0923 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.2681 BP_3 13.00 1.04 895 478254645 ENN74886.1 256 1.2e-19 hypothetical protein YQE_08465, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26811 BP_3 909.97 16.14 3009 91090594 XP_972814.1 2987 0.0e+00 PREDICTED: ATP-binding cassette sub-family F member 3 [Tribolium castaneum]>gi|270013337|gb|EFA09785.1| hypothetical protein TcasGA2_TC011927 [Tribolium castaneum] 755851249 XM_005175430.2 126 1.23383e-56 PREDICTED: Musca domestica ATP-binding cassette sub-family F member 3 (LOC101901338), mRNA K06158 ABCF3 ATP-binding cassette, subfamily F, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06158 Q8K268 2195 2.4e-245 ATP-binding cassette sub-family F member 3 OS=Mus musculus GN=Abcf3 PE=1 SV=1 PF00004//PF01926//PF13304//PF08477//PF00910//PF02601//PF10662//PF03205//PF02367//PF00005//PF03266//PF03193 ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase//RNA helicase//Exonuclease VII, large subunit//Ethanolamine utilisation - propanediol utilisation//Molybdopterin guanine dinucleotide synthesis protein B//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//NTPase//Protein of unknown function, DUF258 GO:0006308//GO:0007264//GO:0006777//GO:0002949//GO:0006200//GO:0006576 DNA catabolic process//small GTPase mediated signal transduction//Mo-molybdopterin cofactor biosynthetic process//tRNA threonylcarbamoyladenosine modification//obsolete ATP catabolic process//cellular biogenic amine metabolic process GO:0003724//GO:0016887//GO:0005525//GO:0003924//GO:0008855//GO:0098519//GO:0005524//GO:0003723 RNA helicase activity//ATPase activity//GTP binding//GTPase activity//exodeoxyribonuclease VII activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//RNA binding GO:0009318 exodeoxyribonuclease VII complex KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b Cluster-8309.26812 BP_3 460.16 5.27 4498 642931322 XP_008196531.1 3232 0.0e+00 PREDICTED: kinase suppressor of Ras 2 isoform X2 [Tribolium castaneum] 642931321 XM_008198309.1 207 1.73755e-101 PREDICTED: Tribolium castaneum kinase suppressor of Ras 2 (LOC661985), transcript variant X2, mRNA K18529 KSR2 kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18529 Q6VAB6 900 5.2e-95 Kinase suppressor of Ras 2 OS=Homo sapiens GN=KSR2 PE=1 SV=2 PF00069//PF06293//PF07714//PF07649//PF00130//PF01146 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Caveolin GO:0006468//GO:0070836//GO:0055114//GO:0035556 protein phosphorylation//caveola assembly//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0016773//GO:0004672//GO:0047134 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein-disulfide reductase activity GO:0016020 membrane KOG0193 Serine/threonine protein kinase RAF Cluster-8309.26813 BP_3 818.00 33.46 1470 91095001 XP_969305.1 1437 2.2e-156 PREDICTED: E3 ubiquitin-protein ligase RNF13 [Tribolium castaneum]>gi|270015391|gb|EFA11839.1| hypothetical protein TcasGA2_TC002100 [Tribolium castaneum] -- -- -- -- -- K15692 RNF13, RZF E3 ubiquitin-protein ligase RNF13 http://www.genome.jp/dbget-bin/www_bget?ko:K15692 Q5RCV8 568 5.4e-57 E3 ubiquitin-protein ligase RNF13 OS=Pongo abelii GN=RNF13 PE=2 SV=1 PF17122//PF00097//PF12906//PF12678//PF17123//PF00628//PF14634//PF11789//PF12861//PF13639 Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-variant domain//RING-H2 zinc finger//RING-like zinc finger//PHD-finger//zinc-RING finger domain//Zinc-finger of the MIZ type in Nse subunit//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG4628 Predicted E3 ubiquitin ligase Cluster-8309.26814 BP_3 45.00 15.18 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26816 BP_3 138.74 5.72 1460 724970788 XP_010357705.1 656 8.1e-66 PREDICTED: myosin light chain alkali-like [Rhinopithecus roxellana] 724970787 XM_010359403.1 392 0 PREDICTED: Rhinopithecus roxellana myosin light chain alkali-like (LOC104659290), mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24756 393 1.0e-36 Myosin light chain alkali OS=Drosophila virilis GN=Mlc1 PE=3 SV=1 PF13499//PF00036//PF13405 EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.26817 BP_3 113.87 1.17 4985 91094409 XP_967943.1 1484 2.7e-161 PREDICTED: acyl-CoA Delta(11) desaturase [Tribolium castaneum]>gi|270016351|gb|EFA12797.1| hypothetical protein TcasGA2_TC014819 [Tribolium castaneum]>gi|576636744|gb|AHH30814.1| fatty acid desaturase D7 [Tribolium castaneum] 817052910 XM_012403667.1 98 7.54557e-41 PREDICTED: Athalia rosae acyl-CoA Delta(11) desaturase (LOC105687776), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 902 3.4e-95 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 PF00096//PF00487 Zinc finger, C2H2 type//Fatty acid desaturase GO:0055114//GO:0006629//GO:0006633 oxidation-reduction process//lipid metabolic process//fatty acid biosynthetic process GO:0016717//GO:0046872 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water//metal ion binding GO:0016021 integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.2682 BP_3 2.00 2.32 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26820 BP_3 347.00 14.69 1430 91090790 XP_970204.1 1502 6.3e-164 PREDICTED: transmembrane protein 115 [Tribolium castaneum]>gi|270013973|gb|EFA10421.1| hypothetical protein TcasGA2_TC012661 [Tribolium castaneum] 665805825 XM_008552904.1 76 3.61092e-29 PREDICTED: Microplitis demolitor transmembrane protein 115 (LOC103573716), mRNA -- -- -- -- Q9WUH1 715 4.7e-74 Transmembrane protein 115 OS=Mus musculus GN=Tmem115 PE=1 SV=1 PF08551//PF01694 Eukaryotic integral membrane protein (DUF1751)//Rhomboid family GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2890 Predicted membrane protein Cluster-8309.26821 BP_3 38.20 1.19 1838 546676408 ERL87426.1 767 1.4e-78 hypothetical protein D910_04820 [Dendroctonus ponderosae] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q8VHB5 330 2.7e-29 Carbonic anhydrase 9 OS=Mus musculus GN=Ca9 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26823 BP_3 7.00 4.79 358 829084927 XP_012648878.1 442 1.3e-41 uncharacterized protein [Babesia microti strain RI]>gi|399217583|emb|CCF74470.1| unnamed protein product [Babesia microti strain RI] 308512649 HM449082.1 215 4.52403e-107 Eriocheir sinensis ubiquitin b mRNA, complete cds K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P0CH07 433 5.9e-42 Ubiquitin-60S ribosomal protein L40 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=uep1 PE=1 SV=1 PF00240//PF01020 Ubiquitin family//Ribosomal L40e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-8309.26824 BP_3 34.00 7.43 512 617378910 XP_007545873.1 393 8.9e-36 PREDICTED: polyubiquitin-B isoform X4 [Poecilia formosa] 260766534 GQ903729.1 508 0 Scylla paramamosain ubiquitin mRNA, complete cds K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 Q63429 385 3.1e-36 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560//PF01599 Ubiquitin family//Ubiquitin-like domain//Ribosomal protein S27a GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.26828 BP_3 9.00 0.74 876 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26830 BP_3 221.00 28.23 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08126 Propeptide_C25 GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.26831 BP_3 659.00 10.26 3387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04810 Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.26836 BP_3 66.15 0.33 9841 315570560 ADU33284.1 2378 1.2e-264 glycoside hydrolase family protein 48 [Chrysomela tremula] 642929104 XM_001810591.2 105 1.91939e-44 PREDICTED: Tribolium castaneum uncharacterized LOC100142047 (LOC100142047), mRNA K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 P50899 1891 1.4e-209 Exoglucanase B OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) GN=cbhB PE=1 SV=1 PF13180//PF15673//PF00595//PF08704//PF02011 PDZ domain//Domain of unknown function (DUF4664)//PDZ domain (Also known as DHR or GLGF)//tRNA methyltransferase complex GCD14 subunit//Glycosyl hydrolase family 48 GO:0005982//GO:0005985//GO:0030488//GO:0009451//GO:0030245//GO:0032922//GO:0005975//GO:0008033 starch metabolic process//sucrose metabolic process//tRNA methylation//RNA modification//cellulose catabolic process//circadian regulation of gene expression//carbohydrate metabolic process//tRNA processing GO:0008810//GO:0004553//GO:0016429//GO:0005515//GO:0000976 cellulase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//tRNA (adenine-N1-)-methyltransferase activity//protein binding//transcription regulatory region sequence-specific DNA binding GO:0031515 tRNA (m1A) methyltransferase complex KOG3528 FOG: PDZ domain Cluster-8309.26837 BP_3 284.91 1.44 9829 642929105 XP_001810643.2 3947 0.0e+00 PREDICTED: uncharacterized protein LOC100142047 [Tribolium castaneum] 642929104 XM_001810591.2 336 7.4206e-173 PREDICTED: Tribolium castaneum uncharacterized LOC100142047 (LOC100142047), mRNA K13804 INAD inactivation no afterpotential D protein http://www.genome.jp/dbget-bin/www_bget?ko:K13804 Q9NB04 802 2.6e-83 Patj homolog OS=Drosophila melanogaster GN=Patj PE=1 SV=2 PF05965//PF13180//PF00595 F/Y rich C-terminus//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding GO:0005634 nucleus KOG3528 FOG: PDZ domain Cluster-8309.26838 BP_3 47.65 3.17 1017 642929105 XP_001810643.2 611 9.3e-61 PREDICTED: uncharacterized protein LOC100142047 [Tribolium castaneum] -- -- -- -- -- K13804 INAD inactivation no afterpotential D protein http://www.genome.jp/dbget-bin/www_bget?ko:K13804 O75970 285 2.4e-24 Multiple PDZ domain protein OS=Homo sapiens GN=MPDZ PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.26841 BP_3 343.00 10.67 1841 642936415 XP_972550.2 310 1.4e-25 PREDICTED: suppression of tumorigenicity 5 protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0006118//GO:0006570//GO:0055114 obsolete electron transport//tyrosine metabolic process//oxidation-reduction process GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.26844 BP_3 3.00 2.00 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26845 BP_3 19.74 1.29 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26850 BP_3 29.81 0.85 1991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26851 BP_3 9.23 0.33 1660 332374670 AEE62476.1 724 1.2e-73 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9LZG0 383 1.7e-35 Adenosine kinase 2 OS=Arabidopsis thaliana GN=ADK2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.26852 BP_3 55.95 1.00 2996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26854 BP_3 664.11 5.91 5709 642928646 XP_008199719.1 1825 8.9e-201 PREDICTED: oxysterol-binding protein-related protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZF3 1247 3.9e-135 Oxysterol-binding protein-related protein 6 OS=Homo sapiens GN=OSBPL6 PE=1 SV=1 PF03623 Focal adhesion targeting region GO:0007172//GO:0006468//GO:0007165 signal complex assembly//protein phosphorylation//signal transduction GO:0004871//GO:0004713 signal transducer activity//protein tyrosine kinase activity GO:0005925 focal adhesion -- -- Cluster-8309.26856 BP_3 24.13 0.35 3584 478256574 ENN76756.1 1921 4.1e-212 hypothetical protein YQE_06597, partial [Dendroctonus ponderosae] -- -- -- -- -- K11652 ACTL6B actin-like protein 6B http://www.genome.jp/dbget-bin/www_bget?ko:K11652 Q99MR0 1271 4.0e-138 Actin-like protein 6B OS=Mus musculus GN=Actl6b PE=1 SV=1 PF07690//PF06723//PF02487 Major Facilitator Superfamily//MreB/Mbl protein//CLN3 protein GO:0000902//GO:0055085 cell morphogenesis//transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG0679 Actin-related protein - Arp4p/Act3p Cluster-8309.26857 BP_3 29.12 1.06 1621 546673667 ERL85231.1 1312 7.7e-142 hypothetical protein D910_02652 [Dendroctonus ponderosae] -- -- -- -- -- K06990 K06990 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06990 Q803S3 958 3.6e-102 Protein MEMO1 OS=Danio rerio GN=memo1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3086 Predicted dioxygenase Cluster-8309.26858 BP_3 2.00 0.84 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26859 BP_3 382.99 16.87 1386 91087295 XP_975560.1 596 7.0e-59 PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum]>gi|642929763|ref|XP_008195964.1| PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V968 522 1.1e-51 MIP18 family protein CG30152 OS=Drosophila melanogaster GN=CG30152 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3381 Uncharacterized conserved protein Cluster-8309.2686 BP_3 2.00 1.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01271 Granin (chromogranin or secretogranin) -- -- -- -- GO:0030141 secretory granule -- -- Cluster-8309.26860 BP_3 4176.05 40.60 5250 817211042 XP_012281638.1 3987 0.0e+00 PREDICTED: catenin alpha [Orussus abietinus]>gi|817211044|ref|XP_012281639.1| PREDICTED: catenin alpha [Orussus abietinus]>gi|817211046|ref|XP_012281640.1| PREDICTED: catenin alpha [Orussus abietinus] 642911688 XM_008202480.1 947 0 PREDICTED: Tribolium castaneum catenin alpha (LOC658703), transcript variant X3, mRNA K05691 CTNNA catenin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05691 P35220 3588 0.0e+00 Catenin alpha OS=Drosophila melanogaster GN=alpha-Cat PE=1 SV=2 PF00328//PF00639//PF03223//PF01044//PF03938//PF08919//PF00435//PF01608//PF04632 Histidine phosphatase superfamily (branch 2)//PPIC-type PPIASE domain//V-ATPase subunit C//Vinculin family//Outer membrane protein (OmpH-like)//F-actin binding//Spectrin repeat//I/LWEQ domain//Fusaric acid resistance protein family GO:0019497//GO:0006810//GO:0006468//GO:0015992//GO:0015991//GO:0006771//GO:0007155 hexachlorocyclohexane metabolic process//transport//protein phosphorylation//proton transport//ATP hydrolysis coupled proton transport//riboflavin metabolic process//cell adhesion GO:0005524//GO:0003779//GO:0015078//GO:0003993//GO:0051015//GO:0051082//GO:0004715//GO:0005515//GO:0016853 ATP binding//actin binding//hydrogen ion transmembrane transporter activity//acid phosphatase activity//actin filament binding//unfolded protein binding//non-membrane spanning protein tyrosine kinase activity//protein binding//isomerase activity GO:0033180//GO:0005886 proton-transporting V-type ATPase, V1 domain//plasma membrane KOG3681 Alpha-catenin Cluster-8309.26861 BP_3 391.00 22.64 1124 91084595 XP_974201.1 812 5.1e-84 PREDICTED: 39S ribosomal protein L44, mitochondrial [Tribolium castaneum]>gi|270008900|gb|EFA05348.1| hypothetical protein TcasGA2_TC015512 [Tribolium castaneum] -- -- -- -- -- K17425 MRPL44 large subunit ribosomal protein L44 http://www.genome.jp/dbget-bin/www_bget?ko:K17425 Q2KIS2 377 5.8e-35 39S ribosomal protein L44, mitochondrial OS=Bos taurus GN=MRPL44 PE=2 SV=1 PF14622 Ribonuclease-III-like GO:0006396//GO:0051252 RNA processing//regulation of RNA metabolic process GO:0004525//GO:0003723 ribonuclease III activity//RNA binding -- -- KOG3769 Ribonuclease III domain proteins Cluster-8309.26862 BP_3 39.86 0.97 2273 91081053 XP_975382.1 431 1.6e-39 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270005322|gb|EFA01770.1| hypothetical protein TcasGA2_TC007369 [Tribolium castaneum] -- -- -- -- -- K00019 E1.1.1.30, bdh 3-hydroxybutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00019 O16881 145 9.3e-08 3 beta-hydroxysteroid dehydrogenase dhs-16 OS=Caenorhabditis elegans GN=dhs-16 PE=2 SV=1 PF10729//PF00106 Cell division activator CedA//short chain dehydrogenase GO:0008152//GO:0051301//GO:0055114 metabolic process//cell division//oxidation-reduction process GO:0000166//GO:0003677//GO:0016491 nucleotide binding//DNA binding//oxidoreductase activity -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.26864 BP_3 289.86 34.64 695 478254757 ENN74994.1 180 6.0e-11 hypothetical protein YQE_08451, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7PSY2 164 1.8e-10 UPF0729 protein AGAP000931 OS=Anopheles gambiae GN=AGAP000931 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26866 BP_3 4311.50 123.31 1977 478252561 ENN72974.1 1491 1.7e-162 hypothetical protein YQE_10405, partial [Dendroctonus ponderosae] 827562517 XM_004933295.2 39 1.85986e-08 PREDICTED: Bombyx mori probable chitinase 2 (LOC101744821), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W092 1062 3.8e-114 Probable chitinase 2 OS=Drosophila melanogaster GN=Cht2 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.26869 BP_3 230.00 6.73 1938 642923549 XP_008193554.1 1209 8.1e-130 PREDICTED: zinc finger and SCAN domain-containing protein 2-like isoform X2 [Tribolium castaneum] 642923548 XM_008195332.1 36 8.4793e-07 PREDICTED: Tribolium castaneum zinc finger and SCAN domain-containing protein 2-like (LOC658870), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5VIY5 333 1.3e-29 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF07776//PF02178//PF00096//PF13465//PF00960//PF00982 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//AT hook motif//Zinc finger, C2H2 type//Zinc-finger double domain//Neocarzinostatin family//Glycosyltransferase family 20 GO:0006952//GO:0005992 defense response//trehalose biosynthetic process GO:0046872//GO:0003824//GO:0008270//GO:0003677 metal ion binding//catalytic activity//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.2687 BP_3 27.00 0.74 2062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26870 BP_3 207.00 10.52 1240 392499121 AFM75821.1 535 7.4e-52 myosin light chain 2 [Procambarus clarkii] 392499120 JX013934.1 281 3.42893e-143 Procambarus clarkii myosin light chain 2 mRNA, complete cds K12757 MYL12 myosin regulatory light chain 12 http://www.genome.jp/dbget-bin/www_bget?ko:K12757 Q1HPS0 372 2.4e-34 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF13202//PF03121//PF13405//PF00036//PF13833//PF13499 EF hand//Herpesviridae UL52/UL70 DNA primase//EF-hand domain//EF hand//EF-hand domain pair//EF-hand domain pair GO:0006269//GO:0006260//GO:0006351 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated GO:0003896//GO:0005509 DNA primase activity//calcium ion binding GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.26872 BP_3 5.00 1.02 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26873 BP_3 172.82 6.65 1544 546682476 ERL92399.1 1061 9.4e-113 hypothetical protein D910_09713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V0D5 589 2.1e-59 Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1 PF02615 Malate/L-lactate dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.26874 BP_3 13.26 0.77 1126 861637402 KMQ92152.1 159 2.7e-08 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26876 BP_3 76.29 3.91 1233 478264795 ENN82329.1 823 3.0e-85 hypothetical protein YQE_01295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 5.2e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.26877 BP_3 399.15 23.31 1117 189233768 XP_001814337.1 800 1.2e-82 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 581 1.3e-58 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086 Jagunal, ER re-organisation during oogenesis GO:0007029 endoplasmic reticulum organization -- -- GO:0005789 endoplasmic reticulum membrane KOG4054 Uncharacterized conserved protein Cluster-8309.26878 BP_3 296.39 7.00 2332 546683161 ERL93009.1 929 2.9e-97 hypothetical protein D910_10311 [Dendroctonus ponderosae] -- -- -- -- -- K04729 MYD88 myeloid differentiation primary response protein MyD88 http://www.genome.jp/dbget-bin/www_bget?ko:K04729 A8QMS7 316 1.4e-27 Myeloid differentiation primary response protein MyD88 OS=Takifugu rubripes GN=myd88 PE=2 SV=1 PF13676//PF01582//PF00531 TIR domain//TIR domain//Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.26879 BP_3 17.12 2.16 673 91092262 XP_967283.1 382 2.2e-34 PREDICTED: methionine aminopeptidase 1 [Tribolium castaneum]>gi|270001228|gb|EEZ97675.1| hypothetical protein TcasGA2_TC016220 [Tribolium castaneum] -- -- -- -- -- K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q5I0A0 313 9.1e-28 Methionine aminopeptidase 1 OS=Xenopus tropicalis GN=metap1 PE=2 SV=1 -- -- GO:0006508//GO:0009987 proteolysis//cellular process GO:0008235//GO:0008270//GO:0004177//GO:0046872 metalloexopeptidase activity//zinc ion binding//aminopeptidase activity//metal ion binding -- -- KOG2738 Putative methionine aminopeptidase Cluster-8309.26880 BP_3 692.04 17.31 2219 270014769 EFA11217.1 676 5.9e-68 hypothetical protein TcasGA2_TC005181 [Tribolium castaneum] 158299715 XM_319761.3 56 7.41712e-18 Anopheles gambiae str. PEST AGAP009016-PA (AgaP_AGAP009016) mRNA, complete cds K16673 LIX1L LIX1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K16673 Q8IVB5 542 8.4e-54 LIX1-like protein OS=Homo sapiens GN=LIX1L PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26884 BP_3 486.55 11.03 2418 642929003 XP_973340.3 1849 6.2e-204 PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|642929005|ref|XP_008195651.1| PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum] 642929004 XM_008197429.1 222 4.25809e-110 PREDICTED: Tribolium castaneum alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC662130), transcript variant X2, mRNA K00726 MGAT1 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00726 P27808 1188 1.1e-128 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat1 PE=2 SV=1 PF03071 GNT-I family GO:0006486 protein glycosylation GO:0008375 acetylglucosaminyltransferase activity -- -- KOG1413 N-acetylglucosaminyltransferase I Cluster-8309.26885 BP_3 141.77 0.40 17285 270012570 EFA09018.1 2931 0.0e+00 hypothetical protein TcasGA2_TC006727 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07929 194 1.5e-12 63 kDa sperm flagellar membrane protein OS=Strongylocentrotus purpuratus PE=2 SV=1 PF07645//PF00335//PF00008 Calcium-binding EGF domain//Tetraspanin family//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021 integral component of membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.26886 BP_3 64.00 3.09 1289 642923174 XP_008193640.1 910 2.5e-95 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- K10402 KIF20 kinesin family member 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10402 O95235 401 1.1e-37 Kinesin-like protein KIF20A OS=Homo sapiens GN=KIF20A PE=1 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule KOG0247 Kinesin-like protein Cluster-8309.26887 BP_3 2041.45 34.96 3106 642930988 XP_008196167.1 1409 8.4e-153 PREDICTED: multiple inositol polyphosphate phosphatase 1 [Tribolium castaneum] -- -- -- -- -- K03103 MINPP1 multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K03103 Q5R890 341 2.4e-30 Multiple inositol polyphosphate phosphatase 1 OS=Pongo abelii GN=MINPP1 PE=2 SV=1 PF00328//PF01529 Histidine phosphatase superfamily (branch 2)//DHHC palmitoyltransferase GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0008270 acid phosphatase activity//zinc ion binding -- -- KOG1382 Multiple inositol polyphosphate phosphatase Cluster-8309.26888 BP_3 638.00 26.41 1456 332375995 AEE63138.1 541 1.7e-52 unknown [Dendroctonus ponderosae]>gi|546680455|gb|ERL90721.1| hypothetical protein D910_08069 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6NYP0 324 1.0e-28 Transmembrane protein 208 OS=Danio rerio GN=tmem208 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3269 Predicted membrane protein Cluster-8309.26889 BP_3 965.00 19.79 2642 642913655 XP_008201106.1 3667 0.0e+00 PREDICTED: nuclear cap-binding protein subunit 1 [Tribolium castaneum] 665389593 NM_080011.3 260 3.50065e-131 Drosophila melanogaster cap binding protein 80 (Cbp80), transcript variant B, mRNA K12882 NCBP1, CBP80 nuclear cap-binding protein subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12882 Q7K4N3 3195 0.0e+00 Nuclear cap-binding protein subunit 1 OS=Drosophila melanogaster GN=Cbp80 PE=1 SV=1 PF00558//PF02854//PF09088//PF09090 Vpu protein//MIF4G domain//MIF4G like//MIF4G like GO:0006812//GO:0032801//GO:0016070//GO:0019076 cation transport//receptor catabolic process//RNA metabolic process//viral release from host cell GO:0003723//GO:0005261//GO:0005515 RNA binding//cation channel activity//protein binding GO:0033644 host cell membrane KOG1104 Nuclear cap-binding complex, subunit NCBP1/CBP80 Cluster-8309.2689 BP_3 9.00 0.52 1120 641678982 XP_008188370.1 461 2.5e-43 PREDICTED: piggyBac transposable element-derived protein 4-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q96DM1 228 1.1e-17 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF07562//PF01155 Nine Cysteines Domain of family 3 GPCR//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0007186 cellular protein modification process//G-protein coupled receptor signaling pathway GO:0016151//GO:0004930 nickel cation binding//G-protein coupled receptor activity -- -- -- -- Cluster-8309.26891 BP_3 96.15 1.27 3945 91094219 XP_973249.1 584 4.9e-57 PREDICTED: uncharacterized protein C9orf85 homolog isoform X2 [Tribolium castaneum]>gi|270016216|gb|EFA12662.1| hypothetical protein TcasGA2_TC002245 [Tribolium castaneum] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q5TZ51 379 1.2e-34 Protein Mpv17 OS=Danio rerio GN=mpv17 PE=2 SV=1 PF04117//PF01990 Mpv17 / PMP22 family//ATP synthase (F/14-kDa) subunit GO:0034220 ion transmembrane transport -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.26893 BP_3 13.52 0.31 2400 642930369 XP_008196368.1 2353 2.2e-262 PREDICTED: dymeclin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q293C2 1434 3.4e-157 Dymeclin OS=Drosophila pseudoobscura pseudoobscura GN=GA20914 PE=3 SV=1 PF04513//PF15499 Baculovirus polyhedron envelope protein, PEP, C terminus//Ubiquitin-specific peptidase-like, SUMO isopeptidase -- -- GO:0032183//GO:0070140//GO:0005198 SUMO binding//SUMO-specific isopeptidase activity//structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG2225 Proteins containing regions of low-complexity Cluster-8309.26896 BP_3 482.32 6.59 3818 91081335 XP_967042.1 5400 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X2 [Tribolium castaneum]>gi|270005182|gb|EFA01630.1| hypothetical protein TcasGA2_TC007200 [Tribolium castaneum] 820837636 XM_012494483.1 538 0 PREDICTED: Apis florea probable phosphorylase b kinase regulatory subunit alpha (LOC100865608), transcript variant X3, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 4434 0.0e+00 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 PF07525 SOCS box GO:0005975//GO:0035556//GO:0005977 carbohydrate metabolic process//intracellular signal transduction//glycogen metabolic process GO:0004553//GO:0005516 hydrolase activity, hydrolyzing O-glycosyl compounds//calmodulin binding -- -- KOG3635 Phosphorylase kinase Cluster-8309.26898 BP_3 27.00 3.23 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12125 D domain of beta-TrCP -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.26900 BP_3 543.96 2.22 12079 546675663 ERL86811.1 3043 0.0e+00 hypothetical protein D910_04215 [Dendroctonus ponderosae] -- -- -- -- -- K10848 ERCC4, XPF DNA excision repair protein ERCC-4 http://www.genome.jp/dbget-bin/www_bget?ko:K10848 P15215 2067 6.7e-230 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 PF06008//PF00927//PF02732//PF08496 Laminin Domain I//Transglutaminase family, C-terminal ig like domain//ERCC4 domain//Peptidase family S49 N-terminal GO:0018149//GO:0007165//GO:0030334//GO:0045995//GO:0030155 peptide cross-linking//signal transduction//regulation of cell migration//regulation of embryonic development//regulation of cell adhesion GO:0003677//GO:0004252//GO:0004518//GO:0005102//GO:0003810 DNA binding//serine-type endopeptidase activity//nuclease activity//receptor binding//protein-glutamine gamma-glutamyltransferase activity GO:0005886 plasma membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.26901 BP_3 84.76 0.78 5544 642911723 XP_008200714.1 359 8.5e-31 PREDICTED: scaffold attachment factor B2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80YR5 202 5.6e-14 Scaffold attachment factor B2 OS=Mus musculus GN=Safb2 PE=2 SV=2 PF06459//PF04111//PF09270//PF00076//PF02932 Ryanodine Receptor TM 4-6//Autophagy protein Apg6//Beta-trefoil DNA-binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Neurotransmitter-gated ion-channel transmembrane region GO:0006816//GO:0006914//GO:0006355//GO:0006811//GO:0006874 calcium ion transport//autophagy//regulation of transcription, DNA-templated//ion transport//cellular calcium ion homeostasis GO:0005219//GO:0003676//GO:0000982//GO:0000978 ryanodine-sensitive calcium-release channel activity//nucleic acid binding//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0005634//GO:0016021//GO:0005622//GO:0016020 nucleus//integral component of membrane//intracellular//membrane -- -- Cluster-8309.26904 BP_3 8.00 0.49 1081 260894289 BAI44499.1 493 4.8e-47 pectate lyase [Aphelenchus avenae]>gi|260894291|dbj|BAI44500.1| pectate lyase [Aphelenchus avenae] 697089108 XM_009659169.1 768 0 Verticillium dahliae VdLs.17 pectate lyase partial mRNA -- -- -- -- A1DBJ7 801 3.8e-84 Probable pectate lyase E OS=Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) GN=plyE PE=3 SV=1 PF03211 Pectate lyase -- -- GO:0030570 pectate lyase activity GO:0005576 extracellular region -- -- Cluster-8309.26906 BP_3 363.12 7.97 2489 332377021 AEE63650.1 2446 3.8e-273 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01303 APEH acylaminoacyl-peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01303 P13676 1008 8.7e-108 Acylamino-acid-releasing enzyme OS=Rattus norvegicus GN=Apeh PE=1 SV=1 PF00326//PF07859//PF02129 Prolyl oligopeptidase family//alpha/beta hydrolase fold//X-Pro dipeptidyl-peptidase (S15 family) GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.26907 BP_3 45.07 0.77 3121 642929021 XP_008195658.1 1369 3.7e-148 PREDICTED: RNA-binding protein Nova-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14944 NOVA RNA-binding protein Nova http://www.genome.jp/dbget-bin/www_bget?ko:K14944 Q2PFW9 486 3.7e-47 RNA-binding protein Nova-1 OS=Macaca fascicularis GN=NOVA1 PE=2 SV=1 PF13014//PF13184//PF00013//PF07650 KH domain//NusA-like KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2191 RNA-binding protein NOVA1/PASILLA and related KH domain proteins Cluster-8309.26908 BP_3 72.00 2.01 2015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2691 BP_3 16.04 0.56 1669 270008069 EFA04517.1 314 4.2e-26 hypothetical protein TcasGA2_TC016312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26911 BP_3 285.60 8.65 1883 91076690 XP_971724.1 1361 1.9e-147 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 126 7.67183e-57 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 A2APY7 818 7.1e-86 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Mus musculus GN=Ndufaf5 PE=2 SV=1 PF05175//PF08241//PF03492//PF01209 Methyltransferase small domain//Methyltransferase domain//SAM dependent carboxyl methyltransferase//ubiE/COQ5 methyltransferase family GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG2940 Predicted methyltransferase Cluster-8309.26912 BP_3 366.02 2.26 8111 642935644 XP_008198096.1 4262 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X5 [Tribolium castaneum] 642935647 XM_008199876.1 244 8.49522e-122 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.4e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF13180//PF00595//PF00620//PF08718 PDZ domain//PDZ domain (Also known as DHR or GLGF)//RhoGAP domain//Glycolipid transfer protein (GLTP) GO:0046836//GO:0007165 glycolipid transport//signal transduction GO:0005515//GO:0017089//GO:0051861 protein binding//glycolipid transporter activity//glycolipid binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.26914 BP_3 323.31 15.91 1271 478257005 ENN77169.1 372 6.0e-33 hypothetical protein YQE_06307, partial [Dendroctonus ponderosae]>gi|546683319|gb|ERL93146.1| hypothetical protein D910_10445 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00003//PF00520 7 transmembrane sweet-taste receptor of 3 GCPR//Ion transport protein GO:0006811//GO:0055085//GO:0007186 ion transport//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0005216 G-protein coupled receptor activity//ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.26916 BP_3 59.33 0.74 4155 642911219 XP_008199637.1 1875 1.0e-206 PREDICTED: FCH domain only protein 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502I9 789 3.6e-82 F-BAR domain only protein 2 OS=Danio rerio GN=fcho2 PE=2 SV=1 PF02050//PF13326//PF01442//PF02662 Flagellar FliJ protein//Photosystem II Pbs27//Apolipoprotein A1/A4/E domain//Methyl-viologen-reducing hydrogenase, delta subunit GO:0010207//GO:0055114//GO:0015948//GO:0006935//GO:0042157//GO:0071973//GO:0006869 photosystem II assembly//oxidation-reduction process//methanogenesis//chemotaxis//lipoprotein metabolic process//bacterial-type flagellum-dependent cell motility//lipid transport GO:0003774//GO:0008289 motor activity//lipid binding GO:0005576//GO:0009288//GO:0016020 extracellular region//bacterial-type flagellum//membrane KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.26917 BP_3 78.59 1.70 2519 861626561 KMQ88832.1 210 7.3e-14 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26920 BP_3 477.47 5.58 4417 642921248 XP_969543.2 924 2.1e-96 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 Q7KQM6 245 4.6e-19 PERQ amino acid-rich with GYF domain-containing protein CG11148 OS=Drosophila melanogaster GN=CG11148 PE=1 SV=2 PF02213 GYF domain -- -- GO:0005515 protein binding -- -- KOG1862 GYF domain containing proteins Cluster-8309.26922 BP_3 13.24 0.76 1131 242018452 XP_002429689.1 266 1.0e-20 fatty acid synthase, putative [Pediculus humanus corporis]>gi|212514692|gb|EEB16951.1| fatty acid synthase, putative [Pediculus humanus corporis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 191 2.1e-13 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- GO:0042967//GO:0008152//GO:0006633 acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process GO:0016297//GO:0016491 acyl-[acyl-carrier-protein] hydrolase activity//oxidoreductase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.26928 BP_3 52.81 3.26 1072 158301484 XP_321166.4 221 1.6e-15 AGAP001899-PA [Anopheles gambiae str. PEST]>gi|157012493|gb|EAA01044.4| AGAP001899-PA [Anopheles gambiae str. PEST] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 164 2.7e-10 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- GO:0003824 catalytic activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.26931 BP_3 13.00 4.42 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26932 BP_3 13.00 0.64 1275 755966256 XP_011305442.1 449 7.1e-42 PREDICTED: fatty acid synthase-like [Fopius arisanus]>gi|755966259|ref|XP_011305443.1| PREDICTED: fatty acid synthase-like [Fopius arisanus] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 306 1.1e-26 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF02424//PF08545//PF00108 ApbE family//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0017013//GO:0008152//GO:0006633//GO:0042967 protein flavinylation//metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.26934 BP_3 600.22 13.47 2439 642928086 XP_008200150.1 3289 0.0e+00 PREDICTED: cleavage and polyadenylation specificity factor 73 [Tribolium castaneum] 642928085 XM_008201928.1 582 0 PREDICTED: Tribolium castaneum cleavage and polyadenylation specificity factor 73 (LOC103314846), mRNA K14403 CPSF3, YSH1 cleavage and polyadenylation specificity factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14403 Q9VE51 2622 6.0e-295 Cleavage and polyadenylation specificity factor 73 OS=Drosophila melanogaster GN=Cpsf73 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1137 mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit) Cluster-8309.26938 BP_3 7.90 31.94 270 642923229 XP_008193666.1 440 1.7e-41 PREDICTED: chromodomain-helicase-DNA-binding protein 7 isoform X2 [Tribolium castaneum] 642923230 XM_008195445.1 162 9.57036e-78 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X3, mRNA K14438 CHD9 chromodomain-helicase-DNA-binding protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14438 Q8BYH8 209 4.2e-16 Chromodomain-helicase-DNA-binding protein 9 OS=Mus musculus GN=Chd9 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26939 BP_3 19.00 1.48 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26940 BP_3 144.00 3.57 2235 749779658 XP_011144362.1 243 9.7e-18 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X2 [Harpegnathos saltator] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 205 1.0e-14 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019//PF13691 Gamma-glutamyltranspeptidase//tRNase Z endonuclease GO:0019530//GO:0008033//GO:0006691//GO:0006693//GO:0006749 taurine metabolic process//tRNA processing//leukotriene metabolic process//prostaglandin metabolic process//glutathione metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.26941 BP_3 47.00 1.22 2145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01194 RNA polymerases N / 8 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.26942 BP_3 20.67 0.46 2451 91088039 XP_974446.1 1345 1.7e-145 PREDICTED: erlin-1 [Tribolium castaneum]>gi|270012079|gb|EFA08527.1| hypothetical protein TcasGA2_TC006180 [Tribolium castaneum] 827559147 XM_012695171.1 184 5.74476e-89 PREDICTED: Bombyx mori erlin-2-like (LOC101740340), transcript variant X3, mRNA -- -- -- -- Q28J34 987 2.3e-105 Erlin-2 OS=Xenopus tropicalis GN=erlin2 PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2962 Prohibitin-related membrane protease subunits Cluster-8309.26945 BP_3 19.83 0.67 1719 642912671 XP_969018.2 897 1.1e-93 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 O35298 829 3.4e-87 Acyloxyacyl hydrolase OS=Mus musculus GN=Aoah PE=2 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26946 BP_3 32.19 0.75 2351 642912671 XP_969018.2 1524 2.9e-166 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 P28039 932 5.3e-99 Acyloxyacyl hydrolase OS=Homo sapiens GN=AOAH PE=1 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26948 BP_3 128.00 9.30 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26949 BP_3 364.00 12.99 1642 91089913 XP_972686.1 1198 1.3e-128 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933954|ref|XP_008197580.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933957|ref|XP_008197581.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013662|gb|EFA10110.1| hypothetical protein TcasGA2_TC012289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 338 2.8e-30 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.26950 BP_3 1034.10 23.74 2391 642916580 XP_008191778.1 2115 8.8e-235 PREDICTED: heterogeneous nuclear ribonucleoprotein L [Tribolium castaneum] 642916579 XM_008193556.1 484 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein L (LOC657712), mRNA K13159 HNRNPL heterogeneous nuclear ribonucleoprotein L http://www.genome.jp/dbget-bin/www_bget?ko:K13159 Q8R081 799 1.4e-83 Heterogeneous nuclear ribonucleoprotein L OS=Mus musculus GN=Hnrnpl PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1456 Heterogeneous nuclear ribonucleoprotein L (contains RRM repeats) Cluster-8309.26952 BP_3 40.00 1.58 1514 817190070 XP_012270387.1 169 2.5e-09 PREDICTED: longitudinals lacking protein, isoform G isoform X41 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q06730 134 1.2e-06 Zinc finger protein 33A OS=Homo sapiens GN=ZNF33A PE=1 SV=3 PF16622//PF01428//PF02892//PF00096//PF13465 zinc-finger C2H2-type//AN1-like Zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.26954 BP_3 6836.17 157.48 2384 642930094 XP_008196249.1 3166 0.0e+00 PREDICTED: uncharacterized protein LOC655867 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 179 1.1e-11 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00095//PF01424//PF02822//PF12740 WAP-type (Whey Acidic Protein) 'four-disulfide core'//R3H domain//Antistasin family//Chlorophyllase enzyme GO:0015994//GO:0015996 chlorophyll metabolic process//chlorophyll catabolic process GO:0030414//GO:0004867//GO:0047746//GO:0003676 peptidase inhibitor activity//serine-type endopeptidase inhibitor activity//chlorophyllase activity//nucleic acid binding GO:0005576 extracellular region KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.26955 BP_3 6096.80 161.62 2110 642930094 XP_008196249.1 2451 8.4e-274 PREDICTED: uncharacterized protein LOC655867 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03610 212 1.5e-15 Uncharacterized protein ZC84.1 OS=Caenorhabditis elegans GN=ZC84.1 PE=3 SV=6 PF00014//PF02822 Kunitz/Bovine pancreatic trypsin inhibitor domain//Antistasin family -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.26958 BP_3 538.00 13.31 2240 642929069 XP_974078.2 1137 2.1e-121 PREDICTED: RING finger and CHY zinc finger domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K10144 RCHY1, PIRH2 RING finger and CHY zinc finger domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10144 Q9CR50 729 1.8e-75 RING finger and CHY zinc finger domain-containing protein 1 OS=Mus musculus GN=Rchy1 PE=1 SV=1 PF14634//PF13639//PF05495 zinc-RING finger domain//Ring finger domain//CHY zinc finger -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1940 Zn-finger protein Cluster-8309.26959 BP_3 4.00 4.18 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2696 BP_3 42.00 4.14 781 91090688 XP_974634.1 437 1.1e-40 PREDICTED: ribonuclease P/MRP protein subunit POP5 [Tribolium castaneum]>gi|270013940|gb|EFA10388.1| hypothetical protein TcasGA2_TC012619 [Tribolium castaneum] -- -- -- -- -- K03537 POP5 ribonuclease P/MRP protein subunit POP5 http://www.genome.jp/dbget-bin/www_bget?ko:K03537 Q5BJI6 191 1.5e-13 Ribonuclease P/MRP protein subunit POP5 OS=Danio rerio GN=pop5 PE=2 SV=1 PF01900 Rpp14/Pop5 family GO:0016070//GO:0051252//GO:0008033 RNA metabolic process//regulation of RNA metabolic process//tRNA processing GO:0004540 ribonuclease activity -- -- -- -- Cluster-8309.26960 BP_3 55.28 0.35 7823 91090704 XP_974824.1 197 7.3e-12 PREDICTED: putative acyl-CoA-binding protein [Tribolium castaneum]>gi|270013948|gb|EFA10396.1| hypothetical protein TcasGA2_TC012627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P31824 160 5.9e-09 Acyl-CoA-binding protein homolog OS=Manduca sexta PE=3 SV=1 PF05777//PF01613//PF03387 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab)//Flavin reductase like domain//Herpesvirus UL46 protein GO:0007617//GO:0006355 mating behavior//regulation of transcription, DNA-templated GO:0000062//GO:0010181 fatty-acyl-CoA binding//FMN binding GO:0005576 extracellular region KOG0817 Acyl-CoA-binding protein Cluster-8309.26964 BP_3 31.50 2.11 1011 332373824 AEE62053.1 803 5.1e-83 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 577 3.3e-58 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.26966 BP_3 368.00 30.99 864 91078414 XP_974638.1 508 7.0e-49 PREDICTED: huntingtin-interacting protein K [Tribolium castaneum]>gi|270004001|gb|EFA00449.1| hypothetical protein TcasGA2_TC003305 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2PFU1 328 2.1e-29 Huntingtin-interacting protein K OS=Macaca fascicularis GN=HYPK PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3450 Huntingtin interacting protein HYPK Cluster-8309.26967 BP_3 78.68 0.97 4216 642913615 XP_008201089.1 3016 0.0e+00 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X4 [Tribolium castaneum]>gi|270002050|gb|EEZ98497.1| hypothetical protein TcasGA2_TC000997 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q5PQN1 1653 2.4e-182 Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0941 E3 ubiquitin protein ligase Cluster-8309.26968 BP_3 26.55 0.31 4378 642913615 XP_008201089.1 2726 2.3e-305 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X4 [Tribolium castaneum]>gi|270002050|gb|EEZ98497.1| hypothetical protein TcasGA2_TC000997 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q5PQN1 1436 3.6e-157 Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0941 E3 ubiquitin protein ligase Cluster-8309.26969 BP_3 249.77 3.10 4178 642913613 XP_008201088.1 4144 0.0e+00 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X3 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q5PQN1 2368 2.9e-265 Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0941 E3 ubiquitin protein ligase Cluster-8309.26971 BP_3 915.47 11.93 3991 642939478 XP_008197026.1 2215 3.7e-246 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 830 6.1e-87 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF04923//PF07690 Ninjurin//Major Facilitator Superfamily GO:0042246//GO:0007155//GO:0055085 tissue regeneration//cell adhesion//transmembrane transport -- -- GO:0016021 integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.26972 BP_3 2.00 0.74 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26975 BP_3 776.82 7.20 5494 91075990 XP_970704.1 2621 4.3e-293 PREDICTED: synaptojanin-1 isoform X1 [Tribolium castaneum]>gi|270014666|gb|EFA11114.1| hypothetical protein TcasGA2_TC004712 [Tribolium castaneum] 642910454 XM_008192523.1 588 0 PREDICTED: Tribolium castaneum synaptojanin-1 (LOC659292), transcript variant X2, mRNA K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 O43426 1661 3.7e-183 Synaptojanin-1 OS=Homo sapiens GN=SYNJ1 PE=1 SV=2 PF02383 SacI homology domain GO:0046854 phosphatidylinositol phosphorylation GO:0042578//GO:0000166 phosphoric ester hydrolase activity//nucleotide binding -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.26976 BP_3 19.00 2.42 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26979 BP_3 277.80 30.90 725 270007276 EFA03724.1 319 4.8e-27 hypothetical protein TcasGA2_TC013829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22978 229 5.4e-18 Heat shock protein 67B2 OS=Drosophila melanogaster GN=Hsp67Bb PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1530 Rhodanese-related sulfurtransferase Cluster-8309.2698 BP_3 6.00 0.65 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26980 BP_3 29.16 2.56 841 270007276 EFA03724.1 142 1.9e-06 hypothetical protein TcasGA2_TC013829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26981 BP_3 547.00 35.66 1031 478261905 ENN80963.1 428 1.6e-39 hypothetical protein YQE_02626, partial [Dendroctonus ponderosae]>gi|546681991|gb|ERL91987.1| hypothetical protein D910_09310 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BRJ6 148 1.9e-08 Uncharacterized protein C7orf50 OS=Homo sapiens GN=C7orf50 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26986 BP_3 7997.78 109.57 3810 478255919 ENN76121.1 2740 4.7e-307 hypothetical protein YQE_07341, partial [Dendroctonus ponderosae]>gi|546676534|gb|ERL87528.1| hypothetical protein D910_04919 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26988 BP_3 988.59 6.70 7408 478253975 ENN74267.1 3685 0.0e+00 hypothetical protein YQE_09239, partial [Dendroctonus ponderosae] 642910904 XM_008195237.1 248 4.63473e-124 PREDICTED: Tribolium castaneum trithorax group protein osa (LOC100141527), mRNA K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 1475 1.8e-161 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 PF01388//PF00375//PF12031//PF15750 ARID/BRIGHT DNA binding domain//Sodium:dicarboxylate symporter family//Domain of unknown function (DUF3518)//Ubiquitin-binding zinc-finger GO:0006812//GO:0006835//GO:0006820//GO:0006338 cation transport//dicarboxylic acid transport//anion transport//chromatin remodeling GO:0017153//GO:0003677//GO:0043130 sodium:dicarboxylate symporter activity//DNA binding//ubiquitin binding GO:0090544//GO:0016020 BAF-type complex//membrane KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-8309.26989 BP_3 34.93 0.78 2462 270009092 EFA05540.1 1887 2.5e-208 hypothetical protein TcasGA2_TC015727 [Tribolium castaneum] 642926476 XM_008193752.1 368 0 PREDICTED: Tribolium castaneum protein suppressor of forked (LOC661644), mRNA K14408 CSTF3, RNA14 cleavage stimulation factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14408 Q99LI7 1383 2.8e-151 Cleavage stimulation factor subunit 3 OS=Mus musculus GN=Cstf3 PE=1 SV=1 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG1914 mRNA cleavage and polyadenylation factor I complex, subunit RNA14 Cluster-8309.2699 BP_3 11.10 0.49 1392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09496 Cenp-O kinetochore centromere component GO:0034508 centromere complex assembly -- -- GO:0000776 kinetochore -- -- Cluster-8309.26990 BP_3 428.78 6.03 3721 642911182 XP_008200615.1 3054 0.0e+00 PREDICTED: WD repeat-containing protein 35 [Tribolium castaneum] 780035245 XM_778124.4 37 4.56379e-07 PREDICTED: Strongylocentrotus purpuratus WD repeat-containing protein 35 (LOC577925), transcript variant X3, mRNA -- -- -- -- A6N6J5 2617 3.5e-294 WD repeat-containing protein 35 OS=Rattus norvegicus GN=Wdr35 PE=1 SV=1 PF13181//PF04053//PF00637 Tetratricopeptide repeat//Coatomer WD associated region//Region in Clathrin and VPS GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG2041 WD40 repeat protein Cluster-8309.26991 BP_3 201.16 1.64 6198 642934158 XP_968636.2 633 1.6e-62 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 378 2.4e-34 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151//PF01805 GNS1/SUR4 family//Surp module GO:0006396 RNA processing GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.26994 BP_3 259.26 11.82 1349 478256925 ENN77094.1 666 5.2e-67 hypothetical protein YQE_06429, partial [Dendroctonus ponderosae]>gi|546683033|gb|ERL92899.1| hypothetical protein D910_10204 [Dendroctonus ponderosae] -- -- -- -- -- K06963 TAN1, THUMPD1 tRNA acetyltransferase TAN1 http://www.genome.jp/dbget-bin/www_bget?ko:K06963 Q9VZD8 442 2.0e-42 THUMP domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG15014 PE=1 SV=2 PF02926//PF03526 THUMP domain//Colicin E1 (microcin) immunity protein GO:0030153//GO:0006955 bacteriocin immunity//immune response GO:0003723//GO:0015643 RNA binding//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.26996 BP_3 89.00 1.80 2673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26999 BP_3 94.00 2.93 1836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27 BP_3 19.00 0.45 2317 189236528 XP_975467.2 2723 2.7e-305 PREDICTED: uncharacterized protein LOC664366 [Tribolium castaneum]>gi|270005304|gb|EFA01752.1| hypothetical protein TcasGA2_TC007350 [Tribolium castaneum] 642920141 XM_970374.3 397 0 PREDICTED: Tribolium castaneum uncharacterized LOC664366 (LOC664366), mRNA -- -- -- -- Q801S4 616 2.3e-62 Uncharacterized protein KIAA0930 homolog OS=Xenopus laevis PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2465 Uncharacterized conserved protein Cluster-8309.2700 BP_3 79.90 20.43 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09496 Cenp-O kinetochore centromere component GO:0034508 centromere complex assembly -- -- GO:0000776 kinetochore -- -- Cluster-8309.27000 BP_3 78.21 1.69 2519 642918373 XP_008200053.1 3550 0.0e+00 PREDICTED: ankyrin-3-like isoform X4 [Tribolium castaneum] 462367530 APGK01026876.1 85 6.38444e-34 Dendroctonus ponderosae Seq01026886, whole genome shotgun sequence K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q01484 2610 1.5e-293 Ankyrin-2 OS=Homo sapiens GN=ANK2 PE=1 SV=4 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27002 BP_3 45.65 0.36 6321 642930587 XP_008198239.1 2586 5.6e-289 PREDICTED: sodium/potassium/calcium exchanger Nckx30C isoform X5 [Tribolium castaneum] 642930586 XM_008200017.1 858 0 PREDICTED: Tribolium castaneum sodium/potassium/calcium exchanger Nckx30C (LOC655611), transcript variant X5, mRNA K13750 SLC24A2, NCKX2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13750 Q9U6A0 2096 1.5e-233 Sodium/potassium/calcium exchanger Nckx30C OS=Drosophila melanogaster GN=Nckx30C PE=2 SV=4 PF05438//PF01699//PF02038//PF00105 Thyrotropin-releasing hormone (TRH)//Sodium/calcium exchanger protein//ATP1G1/PLM/MAT8 family//Zinc finger, C4 type (two domains) GO:0009755//GO:0055085//GO:0006811//GO:0006355//GO:0007218 hormone-mediated signaling pathway//transmembrane transport//ion transport//regulation of transcription, DNA-templated//neuropeptide signaling pathway GO:0005184//GO:0003700//GO:0005216//GO:0043565//GO:0008270 neuropeptide hormone activity//transcription factor activity, sequence-specific DNA binding//ion channel activity//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634//GO:0016021//GO:0005576//GO:0016020 transcription factor complex//nucleus//integral component of membrane//extracellular region//membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.27004 BP_3 38.47 0.84 2507 478253101 ENN73474.1 189 2.0e-11 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04508//PF12567 Viral A-type inclusion protein repeat//Leukocyte receptor CD45 GO:0050852//GO:0006570//GO:0006470//GO:0016032 T cell receptor signaling pathway//tyrosine metabolic process//protein dephosphorylation//viral process GO:0004725 protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.27005 BP_3 7.00 2.06 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27007 BP_3 29.70 0.43 3611 91082907 XP_972373.1 1236 1.1e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.7e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF00787//PF07224//PF12740//PF10503//PF00326 PX domain//Chlorophyllase//Chlorophyllase enzyme//Esterase PHB depolymerase//Prolyl oligopeptidase family GO:0006508//GO:0046294//GO:0015994//GO:0015996//GO:0015947 proteolysis//formaldehyde catabolic process//chlorophyll metabolic process//chlorophyll catabolic process//methane metabolic process GO:0008236//GO:0018738//GO:0035091//GO:0047746 serine-type peptidase activity//S-formylglutathione hydrolase activity//phosphatidylinositol binding//chlorophyllase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.2701 BP_3 11.00 0.71 1038 646717332 KDR20226.1 338 4.3e-29 hypothetical protein L798_05535, partial [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 316 6.3e-28 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF07535//PF02176//PF00096//PF13465//PF05191//PF02892//PF13912 DBF zinc finger//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//Adenylate kinase, active site lid//BED zinc finger//C2H2-type zinc finger GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0046872//GO:0004017//GO:0008270//GO:0003676//GO:0003677 metal ion binding//adenylate kinase activity//zinc ion binding//nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.27010 BP_3 150.00 10.92 954 -- -- -- -- -- 642924012 XM_970745.2 91 1.09273e-37 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27015 BP_3 647.84 12.19 2853 91087855 XP_968688.1 2489 4.5e-278 PREDICTED: vacuolar protein sorting-associated protein 33A [Tribolium castaneum]>gi|270012007|gb|EFA08455.1| hypothetical protein TcasGA2_TC006102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63615 1434 4.0e-157 Vacuolar protein sorting-associated protein 33A OS=Rattus norvegicus GN=Vps33a PE=1 SV=1 PF00995 Sec1 family GO:0006904//GO:0016192 vesicle docking involved in exocytosis//vesicle-mediated transport -- -- -- -- KOG1302 Vacuolar sorting protein VPS33/slp1 (Sec1 family) Cluster-8309.27016 BP_3 22.51 0.44 2736 91086011 XP_972761.1 2152 5.1e-239 PREDICTED: uncharacterized protein LOC661513 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08300 Hepatitis C virus non-structural 5a zinc finger domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.27017 BP_3 2560.00 107.65 1438 646714197 KDR18262.1 1480 2.3e-161 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [Zootermopsis nevadensis] 768953916 XM_011617434.1 209 4.22483e-103 PREDICTED: Takifugu rubripes STT3A, subunit of the oligosaccharyltransferase complex (catalytic) (stt3a), transcript variant X2, mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 P46977 1382 2.1e-151 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens GN=STT3A PE=1 SV=2 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016020 oligosaccharyltransferase complex//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.27018 BP_3 23.09 1.23 1198 642922873 XP_008200433.1 1207 8.5e-130 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [Tribolium castaneum]>gi|270006562|gb|EFA03010.1| hypothetical protein TcasGA2_TC010433 [Tribolium castaneum] 195346084 XM_002039563.1 222 2.07812e-110 Drosophila sechellia GM22642 (Dsec\GM22642), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q5RCE2 1030 1.2e-110 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Pongo abelii GN=STT3A PE=2 SV=1 PF02516//PF10034 Oligosaccharyl transferase STT3 subunit//Q-cell neuroblast polarisation GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016021//GO:0016020 oligosaccharyltransferase complex//integral component of membrane//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.27020 BP_3 83.00 19.01 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27021 BP_3 686.77 11.62 3140 270004099 EFA00547.1 894 4.4e-93 hypothetical protein TcasGA2_TC003413 [Tribolium castaneum] 442633737 NM_176374.2 163 3.48173e-77 Drosophila melanogaster knirps-like (knrl), mRNA K08706 NR0AN, kni nuclear receptor subfamily 0 group A http://www.genome.jp/dbget-bin/www_bget?ko:K08706 P13054 507 1.4e-49 Knirps-related protein OS=Drosophila melanogaster GN=knrl PE=2 SV=1 PF00105//PF00645 Zinc finger, C4 type (two domains)//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0008270//GO:0003700 DNA binding//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.27022 BP_3 13.00 0.59 1355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.27032 BP_3 97.12 2.59 2101 91092806 XP_967025.1 2066 3.7e-229 PREDICTED: protein henna [Tribolium castaneum]>gi|270003060|gb|EEZ99507.1| hypothetical protein TcasGA2_TC000087 [Tribolium castaneum] -- -- -- -- -- K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 1713 1.3e-189 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF01842//PF00351 ACT domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0008152//GO:0006559//GO:0009094//GO:0055114//GO:0006571//GO:0000162 metabolic process//L-phenylalanine catabolic process//L-phenylalanine biosynthetic process//oxidation-reduction process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0016714//GO:0016597//GO:0005506//GO:0004505 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//amino acid binding//iron ion binding//phenylalanine 4-monooxygenase activity -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.27034 BP_3 84.06 0.99 4383 642926286 XP_008194862.1 2477 1.7e-276 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like [Tribolium castaneum] 642926285 XM_008196640.1 273 3.46259e-138 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1579 9.4e-174 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF00069//PF01392//PF07714//PF13895 Protein kinase domain//Fz domain//Protein tyrosine kinase//Immunoglobulin domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.27035 BP_3 20.00 1.76 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27037 BP_3 53.88 1.69 1824 270008771 EFA05219.1 1061 1.1e-112 hypothetical protein TcasGA2_TC015360 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51814 395 7.7e-37 Zinc finger protein 41 OS=Homo sapiens GN=ZNF41 PE=1 SV=2 PF13912//PF02892//PF16622//PF07776//PF13465//PF00096//PF05443 C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//ROS/MUCR transcriptional regulator protein GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.27039 BP_3 254.92 5.38 2576 642933271 XP_008197352.1 668 5.8e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933270 XM_008199130.1 229 5.83199e-114 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X1, mRNA -- -- -- -- Q65Z95 602 1.1e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.27041 BP_3 1.00 1.43 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27042 BP_3 42.00 0.50 4326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27043 BP_3 8.00 1.09 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27047 BP_3 76.60 0.53 7200 270005904 EFA02352.1 2947 0.0e+00 hypothetical protein TcasGA2_TC008022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 754 7.1e-78 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3321 Mitochondrial ribosomal protein S10 Cluster-8309.27052 BP_3 16.29 1.63 774 189236834 XP_001812569.1 702 2.0e-71 PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|270005053|gb|EFA01501.1| hypothetical protein TcasGA2_TC007057 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0005488//GO:0008270//GO:0046872 binding//zinc ion binding//metal ion binding GO:0005634//GO:0005622 nucleus//intracellular -- -- Cluster-8309.27053 BP_3 864.10 6.73 6479 642918446 XP_008191478.1 2992 0.0e+00 PREDICTED: protein zer-1 homolog [Tribolium castaneum]>gi|270003243|gb|EEZ99690.1| hypothetical protein TcasGA2_TC002447 [Tribolium castaneum] 769838188 XM_011631947.1 151 3.38471e-70 PREDICTED: Pogonomyrmex barbatus probable deoxyhypusine synthase (LOC105422536), transcript variant X6, mRNA K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q9W0E8 1706 2.6e-188 Protein zer-1 homolog OS=Drosophila melanogaster GN=CG12084 PE=2 SV=2 PF01916//PF13855//PF00514//PF03792//PF00560 Deoxyhypusine synthase//Leucine rich repeat//Armadillo/beta-catenin-like repeat//PBC domain//Leucine Rich Repeat GO:0008612 peptidyl-lysine modification to peptidyl-hypusine GO:0003700//GO:0005515 transcription factor activity, sequence-specific DNA binding//protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG2924 Deoxyhypusine synthase Cluster-8309.27054 BP_3 32.72 2.07 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27056 BP_3 288.43 3.10 4770 332374190 AEE62236.1 1090 1.3e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02967 RP-S2, MRPS2, rpsB small subunit ribosomal protein S2 http://www.genome.jp/dbget-bin/www_bget?ko:K02967 Q9Y399 684 6.2e-70 28S ribosomal protein S2, mitochondrial OS=Homo sapiens GN=MRPS2 PE=1 SV=1 PF00318//PF02558//PF01370//PF00106 Ribosomal protein S2//Ketopantoate reductase PanE/ApbA//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0042254//GO:0055114//GO:0006412//GO:0015940//GO:0008152 ribosome biogenesis//oxidation-reduction process//translation//pantothenate biosynthetic process//metabolic process GO:0008677//GO:0003735//GO:0016491//GO:0050662//GO:0003824 2-dehydropantoate 2-reductase activity//structural constituent of ribosome//oxidoreductase activity//coenzyme binding//catalytic activity GO:0005622//GO:0005840 intracellular//ribosome KOG1205 Predicted dehydrogenase Cluster-8309.27057 BP_3 17.31 0.54 1840 546679701 ERL90124.1 140 7.0e-06 hypothetical protein D910_07478 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27059 BP_3 16.20 0.37 2381 642910579 XP_008200011.1 220 4.8e-15 PREDICTED: cap-n-collar isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2706 BP_3 17.44 0.34 2731 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27062 BP_3 910.23 8.14 5679 642933274 XP_008197353.1 3621 0.0e+00 PREDICTED: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 [Tribolium castaneum] 850480667 CP011888.1 37 6.98873e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 1848 7.8e-205 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF00443//PF09061//PF01612//PF03798//PF05868 Ubiquitin carboxyl-terminal hydrolase//Stirrup//3'-5' exonuclease//TLC domain//Rotavirus major outer capsid protein VP7 GO:0016579//GO:0006139 protein deubiquitination//nucleobase-containing compound metabolic process GO:0008408//GO:0003676//GO:0036459//GO:0016788 3'-5' exonuclease activity//nucleic acid binding//ubiquitinyl hydrolase activity//hydrolase activity, acting on ester bonds GO:0019012//GO:0016021 virion//integral component of membrane KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.27063 BP_3 633.51 14.03 2468 189233973 XP_975713.2 2235 1.1e-248 PREDICTED: serine/threonine-protein kinase 3 [Tribolium castaneum]>gi|270014571|gb|EFA11019.1| hypothetical protein TcasGA2_TC004606 [Tribolium castaneum] 156389256 XM_001634858.1 179 3.48178e-86 Nematostella vectensis predicted protein (NEMVEDRAFT_v1g241948) partial mRNA K04412 STK3, MST2 serine/threonine kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04412 Q6IP06 1497 1.7e-164 Serine/threonine-protein kinase 3 OS=Xenopus laevis GN=stk3 PE=2 SV=1 PF00069//PF07714//PF11629//PF16517 Protein kinase domain//Protein tyrosine kinase//C terminal SARAH domain of Mst1//Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain GO:0007165//GO:0006468//GO:0009069//GO:0016310 signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0574 STE20-like serine/threonine kinase MST Cluster-8309.27064 BP_3 1.00 4.57 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27066 BP_3 691.97 13.28 2804 642930412 XP_008196389.1 2518 1.9e-281 PREDICTED: beta-mannosidase-like [Tribolium castaneum] 537740069 HG315671.1 48 2.63141e-13 Formosa agariphila KMM 3901, complete genome K01192 E3.2.1.25, MANBA, manB beta-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01192 Q95327 1676 3.4e-185 Beta-mannosidase OS=Capra hircus GN=MANBA PE=2 SV=1 PF02837//PF00703//PF07527//PF02836 Glycosyl hydrolases family 2, sugar binding domain//Glycosyl hydrolases family 2//Hairy Orange//Glycosyl hydrolases family 2, TIM barrel domain GO:0006355//GO:0005975 regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0003677//GO:0004553 DNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2230 Predicted beta-mannosidase Cluster-8309.27068 BP_3 382.48 7.44 2768 478256149 ENN76347.1 3557 0.0e+00 hypothetical protein YQE_07124, partial [Dendroctonus ponderosae] 817202050 XM_012421374.1 256 6.13677e-129 PREDICTED: Orussus abietinus DNA replication licensing factor Mcm2 (LOC105697752), mRNA K02540 MCM2 DNA replication licensing factor MCM2 http://www.genome.jp/dbget-bin/www_bget?ko:K02540 P49735 3053 0.0e+00 DNA replication licensing factor Mcm2 OS=Drosophila melanogaster GN=Mcm2 PE=1 SV=1 PF00493//PF00004//PF12619//PF07728//PF07726//PF00158 MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//Mini-chromosome maintenance protein 2//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain GO:0006270//GO:0006355//GO:0006260 DNA replication initiation//regulation of transcription, DNA-templated//DNA replication GO:0003678//GO:0005524//GO:0003677//GO:0008134//GO:0016887 DNA helicase activity//ATP binding//DNA binding//transcription factor binding//ATPase activity GO:0005634//GO:0005657//GO:0005667//GO:0042555 nucleus//replication fork//transcription factor complex//MCM complex KOG0477 DNA replication licensing factor, MCM2 component Cluster-8309.27069 BP_3 11.00 0.72 1033 255522805 NP_001157315.1 162 1.1e-08 longitudinals lacking isoform 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.2707 BP_3 5.00 0.74 618 357614006 EHJ68851.1 327 4.9e-28 cuticular protein RR-2 motif 73 [Danaus plexippus] -- -- -- -- -- -- -- -- -- P80683 306 5.4e-27 Larval cuticle protein A3A OS=Tenebrio molitor PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.27070 BP_3 30.40 0.36 4374 642933797 XP_008197328.1 2022 9.8e-224 PREDICTED: multidrug resistance-associated protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q8HXQ5 1232 1.6e-133 Multidrug resistance-associated protein 1 OS=Bos taurus GN=ABCC1 PE=2 SV=1 PF13304//PF01926//PF00664//PF03193//PF00005//PF17001//PF06414//PF09547//PF01637//PF08603 AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Zeta toxin//Stage IV sporulation protein A (spore_IV_A)//Archaeal ATPase//Adenylate cyclase associated (CAP) C terminal GO:0009306//GO:0007010//GO:0006810//GO:0055085//GO:0043934 protein secretion//cytoskeleton organization//transport//transmembrane transport//sporulation GO:0003924//GO:0003779//GO:0005524//GO:0042626//GO:0005525//GO:0016887//GO:0016301 GTPase activity//actin binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.27073 BP_3 308.92 2.96 5318 91076774 XP_973840.1 1189 4.6e-127 PREDICTED: autophagy protein 5 [Tribolium castaneum]>gi|270001850|gb|EEZ98297.1| hypothetical protein TcasGA2_TC000747 [Tribolium castaneum] 170060949 XM_001865993.1 65 1.78062e-22 Culex quinquefasciatus Autophagy-specific protein, mRNA K08339 ATG5 autophagy-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08339 Q9W3R7 857 6.0e-90 Autophagy protein 5 OS=Drosophila melanogaster GN=Atg5 PE=2 SV=2 PF07728//PF04106//PF16094//PF06309//PF03135 AAA domain (dynein-related subfamily)//Autophagy protein Apg5//Proteasome assembly chaperone 4//Torsin//CagE, TrbE, VirB family, component of type IV transporter system GO:0043248//GO:0006914 proteasome assembly//autophagy GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0005737//GO:0005783 cytoplasm//endoplasmic reticulum KOG2170 ATPase of the AAA+ superfamily Cluster-8309.27075 BP_3 393.81 6.40 3257 91085763 XP_974155.1 2794 0.0e+00 PREDICTED: polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270009999|gb|EFA06447.1| hypothetical protein TcasGA2_TC009329 [Tribolium castaneum] -- -- -- -- -- K00962 pnp, PNPT1 polyribonucleotide nucleotidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00962 Q8TCS8 2002 6.2e-223 Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=PNPT1 PE=1 SV=2 PF03726//PF00013//PF00575 Polyribonucleotide nucleotidyltransferase, RNA binding domain//KH domain//S1 RNA binding domain GO:0006206//GO:0006396//GO:0051252//GO:0006402//GO:0006144 pyrimidine nucleobase metabolic process//RNA processing//regulation of RNA metabolic process//mRNA catabolic process//purine nucleobase metabolic process GO:0003676//GO:0003723//GO:0004654//GO:0000175 nucleic acid binding//RNA binding//polyribonucleotide nucleotidyltransferase activity//3'-5'-exoribonuclease activity -- -- KOG1067 Predicted RNA-binding polyribonucleotide nucleotidyltransferase Cluster-8309.27076 BP_3 1.54 0.34 513 478256535 ENN76719.1 418 1.1e-38 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8NB50 265 2.5e-22 Zinc finger protein 62 homolog OS=Homo sapiens GN=ZFP62 PE=2 SV=3 PF13465//PF00096//PF13912//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.27077 BP_3 113.22 3.36 1918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27078 BP_3 103.00 6.42 1065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2708 BP_3 1986.59 161.95 883 642930071 XP_008196238.1 169 1.5e-09 PREDICTED: proline-rich protein 4, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27080 BP_3 854.38 14.18 3196 642918916 XP_008191654.1 4256 0.0e+00 PREDICTED: apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1 [Tribolium castaneum] 194759777 XM_001962088.1 63 1.37802e-21 Drosophila ananassae GF14596 (Dana\GF14596), mRNA -- -- -- -- O15033 1602 1.5e-176 Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Homo sapiens GN=AREL1 PE=1 SV=3 PF00632//PF00536//PF07647 HECT-domain (ubiquitin-transferase)//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.27081 BP_3 52.03 1.22 2342 642918918 XP_008191656.1 1771 6.7e-195 PREDICTED: apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2 [Tribolium castaneum] 194759777 XM_001962088.1 63 1.00636e-21 Drosophila ananassae GF14596 (Dana\GF14596), mRNA -- -- -- -- Q8CHG5 397 5.8e-37 Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Mus musculus GN=Arel1 PE=2 SV=2 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27083 BP_3 78.24 0.78 5137 478251566 ENN72028.1 701 1.7e-70 hypothetical protein YQE_11319, partial [Dendroctonus ponderosae] 847108462 XR_001170156.1 36 2.27217e-06 PREDICTED: Xenopus (Silurana) tropicalis transmembrane protein 110 (tmem110), transcript variant X1, misc_RNA -- -- -- -- Q86TL2 352 2.1e-31 Transmembrane protein 110 OS=Homo sapiens GN=TMEM110 PE=2 SV=1 PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27084 BP_3 134.36 1.43 4816 642931607 XP_008196654.1 2938 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 639 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 2276 1.6e-254 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF02170//PF02171//PF04810 PAZ domain//Piwi domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270//GO:0005515 nucleic acid binding//zinc ion binding//protein binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.27085 BP_3 31.05 1.11 1640 642930414 XP_008196390.1 488 2.8e-46 PREDICTED: BAG family molecular chaperone regulator 2 [Tribolium castaneum]>gi|270009406|gb|EFA05854.1| hypothetical protein TcasGA2_TC008649 [Tribolium castaneum] -- -- -- -- -- K09556 BAG2 BCL2-associated athanogene 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09556 Q91YN9 217 3.0e-16 BAG family molecular chaperone regulator 2 OS=Mus musculus GN=Bag2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3633 BAG family molecular chaperone regulator 2 Cluster-8309.27086 BP_3 381.95 9.38 2255 478255733 ENN75942.1 1756 3.5e-193 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 789 2.0e-82 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 PF08119//PF00097 Scorpion acidic alpha-KTx toxin family//Zinc finger, C3HC4 type (RING finger) GO:0009405//GO:0006810 pathogenesis//transport GO:0046872//GO:0019870 metal ion binding//potassium channel inhibitor activity GO:0005576 extracellular region KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.27089 BP_3 166.73 2.84 3121 642935794 XP_008198177.1 372 1.5e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03823//PF00335//PF01694 Neurokinin B//Tetraspanin family//Rhomboid family GO:0007217 tachykinin receptor signaling pathway GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.27090 BP_3 72.00 2.53 1661 642937618 XP_008199124.1 681 1.2e-68 PREDICTED: barH-like 1 homeobox protein [Tribolium castaneum] 345483554 XM_003424793.1 113 1.13757e-49 PREDICTED: Nasonia vitripennis homeobox protein B-H2-like (LOC100679231), mRNA K09360 BARHL BarH-like http://www.genome.jp/dbget-bin/www_bget?ko:K09360 Q24255 513 1.4e-50 Homeobox protein B-H1 OS=Drosophila melanogaster GN=B-H1 PE=2 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0488 Transcription factor BarH and related HOX domain proteins Cluster-8309.27092 BP_3 89.03 12.46 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27093 BP_3 5.97 0.57 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27094 BP_3 128.13 2.28 3001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27095 BP_3 289.82 1.97 7372 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 8.7e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF08477//PF03810//PF01926//PF07817//PF02421//PF03193//PF00071//PF04548 Ras of Complex, Roc, domain of DAPkinase//Importin-beta N-terminal domain//50S ribosome-binding GTPase//GLE1-like protein//Ferrous iron transport protein B//Protein of unknown function, DUF258//Ras family//AIG1 family GO:0016973//GO:0006886//GO:0015031//GO:0015684//GO:0007264 poly(A)+ mRNA export from nucleus//intracellular protein transport//protein transport//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0008536//GO:0015093//GO:0008565//GO:0005525 GTPase activity//Ran GTPase binding//ferrous iron transmembrane transporter activity//protein transporter activity//GTP binding GO:0016021//GO:0005643 integral component of membrane//nuclear pore KOG3068 mRNA splicing factor Cluster-8309.27096 BP_3 144.43 0.93 7743 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 9.2e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF00071//PF02421//PF08477//PF03810//PF03193//PF01926//PF07817 Ras family//Ferrous iron transport protein B//Ras of Complex, Roc, domain of DAPkinase//Importin-beta N-terminal domain//Protein of unknown function, DUF258//50S ribosome-binding GTPase//GLE1-like protein GO:0007264//GO:0015031//GO:0015684//GO:0006886//GO:0016973 small GTPase mediated signal transduction//protein transport//ferrous iron transport//intracellular protein transport//poly(A)+ mRNA export from nucleus GO:0005525//GO:0008565//GO:0008536//GO:0003924//GO:0015093 GTP binding//protein transporter activity//Ran GTPase binding//GTPase activity//ferrous iron transmembrane transporter activity GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.27097 BP_3 1.00 0.50 387 123423385 XP_001306365.1 235 1.4e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121887935|gb|EAX93435.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 230 2.2e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27098 BP_3 4.00 1.20 452 780175874 XP_011661330.1 234 2.1e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q8ZWC4 220 3.7e-17 Putative ankyrin repeat protein PAE1861 OS=Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) GN=PAE1861 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27099 BP_3 4.00 4.18 329 642934266 XP_008200866.1 158 1.0e-08 PREDICTED: uncharacterized protein LOC103314998 isoform X26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2RXR6 147 7.9e-09 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Mus musculus GN=Ankrd44 PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27101 BP_3 49.78 0.76 3461 642915300 XP_008190561.1 1651 8.1e-181 PREDICTED: JNK-interacting protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60271 905 1.1e-95 C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens GN=SPAG9 PE=1 SV=4 PF10473//PF17082//PF00458//PF01763//PF06156//PF04111//PF01496//PF04508//PF10186 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Spindle Pole Component 29//WHEP-TRS domain//Herpesvirus UL6 like//Protein of unknown function (DUF972)//Autophagy protein Apg6//V-type ATPase 116kDa subunit family//Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0030474//GO:0015991//GO:0016032//GO:0006418//GO:0006914//GO:0006323//GO:0015992//GO:0010508//GO:0006260 spindle pole body duplication//ATP hydrolysis coupled proton transport//viral process//tRNA aminoacylation for protein translation//autophagy//DNA packaging//proton transport//positive regulation of autophagy//DNA replication GO:0042803//GO:0008134//GO:0045502//GO:0005524//GO:0004812//GO:0005200//GO:0015078 protein homodimerization activity//transcription factor binding//dynein binding//ATP binding//aminoacyl-tRNA ligase activity//structural constituent of cytoskeleton//hydrogen ion transmembrane transporter activity GO:0005667//GO:0005856//GO:0030286//GO:0033179//GO:0005823 transcription factor complex//cytoskeleton//dynein complex//proton-transporting V-type ATPase, V0 domain//central plaque of spindle pole body KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.27102 BP_3 3.00 0.39 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27103 BP_3 34.96 2.44 982 270004583 EFA01031.1 541 1.2e-52 hypothetical protein TcasGA2_TC003947 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P35789 481 4.4e-47 Zinc finger protein 93 OS=Homo sapiens GN=ZNF93 PE=2 SV=4 PF00096//PF13465//PF13912//PF01258 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.27105 BP_3 606.00 30.74 1242 91084417 XP_967827.1 582 2.6e-57 PREDICTED: chromobox protein homolog 3 [Tribolium castaneum]>gi|270008703|gb|EFA05151.1| hypothetical protein TcasGA2_TC015268 [Tribolium castaneum] -- -- -- -- -- K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83917 433 2.1e-41 Chromobox protein homolog 1 OS=Mus musculus GN=Cbx1 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.27106 BP_3 9.00 0.58 1044 646715617 KDR19153.1 141 3.0e-06 Aladin [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27107 BP_3 38.94 0.41 4838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27108 BP_3 36.37 0.31 5960 546684232 ERL93937.1 455 6.7e-42 hypothetical protein D910_11223 [Dendroctonus ponderosae] -- -- -- -- -- K19480 ANO5, GDD1, TMEM16E anoctamin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K19480 Q75V66 183 9.6e-12 Anoctamin-5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 PF01091//PF13939//PF16178 PTN/MK heparin-binding protein family, C-terminal domain//Toxin TisB, type I toxin-antitoxin system//Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0040007//GO:0007165//GO:0008283//GO:0009432//GO:0022611//GO:0006820 growth//signal transduction//cell proliferation//SOS response//dormancy process//anion transport GO:0008083//GO:0046983//GO:0005253 growth factor activity//protein dimerization activity//anion channel activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.2711 BP_3 41.00 0.98 2299 668460984 KFB48579.1 720 4.8e-73 AGAP007069-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- Q09225 325 1.3e-28 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF02687//PF01757 FtsX-like permease family//Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016020 membrane -- -- Cluster-8309.27111 BP_3 276.06 12.32 1372 546684237 ERL93942.1 377 1.7e-33 hypothetical protein D910_11228 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27112 BP_3 1.00 0.61 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27114 BP_3 17.54 2.96 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27115 BP_3 275.15 4.87 3013 91086463 XP_969857.1 1953 6.7e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1236 3.8e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.27116 BP_3 1146.33 20.56 2979 91086463 XP_969857.1 1953 6.7e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1236 3.8e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.27117 BP_3 550.28 8.61 3372 478251404 ENN71870.1 492 1.9e-46 hypothetical protein YQE_11485, partial [Dendroctonus ponderosae] 449102215 JX081307.1 150 6.30609e-70 Pleurobrachia bachei dynein light chain-2 mRNA, complete cds K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q78P75 465 1.1e-44 Dynein light chain 2, cytoplasmic OS=Rattus norvegicus GN=Dynll2 PE=1 SV=1 PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.27118 BP_3 87.38 1.35 3417 546685535 ERL95022.1 492 2.0e-46 hypothetical protein D910_12292 [Dendroctonus ponderosae] 449102215 JX081307.1 150 6.39115e-70 Pleurobrachia bachei dynein light chain-2 mRNA, complete cds K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q78P75 465 1.1e-44 Dynein light chain 2, cytoplasmic OS=Rattus norvegicus GN=Dynll2 PE=1 SV=1 PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.27119 BP_3 18.00 0.43 2296 478251404 ENN71870.1 195 3.6e-12 hypothetical protein YQE_11485, partial [Dendroctonus ponderosae] 642926604 XM_964175.3 67 5.89409e-24 PREDICTED: Tribolium castaneum dynein light chain D (LOC657733), mRNA K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q9D0M5 175 3.1e-11 Dynein light chain 2, cytoplasmic OS=Mus musculus GN=Dynll2 PE=1 SV=1 PF04542//PF01221 Sigma-70 region 2//Dynein light chain type 1 GO:0006352//GO:0007017//GO:0006355 DNA-templated transcription, initiation//microtubule-based process//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0016987 DNA binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667//GO:0005875 transcription factor complex//microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.27121 BP_3 2.21 0.39 565 642932174 XP_008196886.1 179 6.4e-11 PREDICTED: RE1-silencing transcription factor B-like [Tribolium castaneum]>gi|270011690|gb|EFA08138.1| hypothetical protein TcasGA2_TC005755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54963 160 4.2e-10 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.27122 BP_3 11.45 1.47 668 665792068 XP_008543619.1 200 2.8e-13 PREDICTED: zinc finger protein 888-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P17012 168 5.9e-11 Zinc finger X-chromosomal protein OS=Mus musculus GN=Zfx PE=1 SV=2 PF04988//PF01096//PF13465//PF00096//PF16622 A-kinase anchoring protein 95 (AKAP95)//Transcription factor S-II (TFIIS)//Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type GO:0006351 transcription, DNA-templated GO:0008270//GO:0003676//GO:0003677//GO:0046872 zinc ion binding//nucleic acid binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.27123 BP_3 2236.05 24.50 4690 546678980 ERL89513.1 1263 1.1e-135 hypothetical protein D910_06879 [Dendroctonus ponderosae] 850318596 XM_013007893.1 39 4.45575e-08 PREDICTED: Echinops telfairi L-lactate dehydrogenase A chain-like (LOC101645051), mRNA K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 1195 3.4e-129 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF00056//PF03721//PF02427//PF02737//PF02866 lactate/malate dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Photosystem I reaction centre subunit IV / PsaE//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0006552//GO:0006631//GO:0015979//GO:0018874//GO:0006633//GO:0006554//GO:0055114//GO:0006568//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//photosynthesis//benzoate metabolic process//fatty acid biosynthetic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//valine catabolic process//isoleucine catabolic process GO:0016491//GO:0051287//GO:0003857//GO:0016616 oxidoreductase activity//NAD binding//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0009538//GO:0009522 photosystem I reaction center//photosystem I KOG1495 Lactate dehydrogenase Cluster-8309.27124 BP_3 278.47 2.13 6607 642921412 XP_008192854.1 1035 4.1e-109 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.59356e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 747 4.2e-77 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.27125 BP_3 672.00 30.09 1368 642931070 XP_008196199.1 579 6.4e-57 PREDICTED: uncharacterized protein LOC103313796 [Tribolium castaneum]>gi|270012066|gb|EFA08514.1| hypothetical protein TcasGA2_TC006167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27126 BP_3 233.40 13.75 1110 817079505 XP_012262173.1 280 2.5e-22 PREDICTED: zinc finger protein 706-like [Athalia rosae]>gi|817079507|ref|XP_012262174.1| PREDICTED: zinc finger protein 706-like [Athalia rosae] 389609616 AK401798.1 81 4.62922e-32 Papilio xuthus mRNA for similar to CG15715, complete cds, sequence id: Px-1382 -- -- -- -- Q5ZMM5 201 1.5e-14 Zinc finger protein 706 OS=Gallus gallus GN=ZNF706 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4118 Uncharacterized conserved protein Cluster-8309.27127 BP_3 244.12 9.43 1540 332372985 AEE61634.1 1497 2.6e-163 unknown [Dendroctonus ponderosae] 642937798 XM_008202083.1 221 9.67218e-110 PREDICTED: Tribolium castaneum cleavage stimulation factor subunit 2 tau variant (LOC659353), mRNA K14407 CSTF2, RNA15 cleavage stimulation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14407 Q8HXM1 717 3.0e-74 Cleavage stimulation factor subunit 2 OS=Bos taurus GN=CSTF2 PE=2 SV=1 PF00076//PF16367//PF14304 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Transcription termination and cleavage factor C-terminal GO:0031124 mRNA 3'-end processing GO:0003676 nucleic acid binding -- -- KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15 Cluster-8309.27129 BP_3 1681.73 35.25 2591 642922164 XP_008193042.1 3107 0.0e+00 PREDICTED: glycine--tRNA ligase [Tribolium castaneum] 170050074 XM_001859151.1 174 2.20143e-83 Culex quinquefasciatus glycyl-tRNA synthetase, mRNA K01880 GARS, glyS1 glycyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01880 Q04451 2649 4.7e-298 Glycine--tRNA ligase OS=Bombyx mori PE=1 SV=2 PF00458//PF00587 WHEP-TRS domain//tRNA synthetase class II core domain (G, H, P, S and T) GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding -- -- KOG2298 Glycyl-tRNA synthetase and related class II tRNA synthetase Cluster-8309.27130 BP_3 693.51 6.08 5793 478255041 ENN75273.1 1173 3.6e-125 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 658861642 XM_008415365.1 133 3.06887e-60 PREDICTED: Poecilia reticulata phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 1058 3.2e-113 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF01409//PF00520//PF15461 tRNA synthetases class II core domain (F)//Ion transport protein//Beta-carotene 15,15'-dioxygenase GO:0055085//GO:0006811//GO:0055114//GO:0043039//GO:0006418 transmembrane transport//ion transport//oxidation-reduction process//tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0000049//GO:0016702//GO:0005524//GO:0004812//GO:0005216 tRNA binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//ATP binding//aminoacyl-tRNA ligase activity//ion channel activity GO:0005737//GO:0016020 cytoplasm//membrane KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.27131 BP_3 50.84 0.98 2788 91089737 XP_975124.1 1653 3.8e-181 PREDICTED: protein RFT1 homolog [Tribolium castaneum]>gi|270011306|gb|EFA07754.1| hypothetical protein TcasGA2_TC005308 [Tribolium castaneum] -- -- -- -- -- K06316 RFT1 oligosaccharide translocation protein RFT1 http://www.genome.jp/dbget-bin/www_bget?ko:K06316 Q9Y123 1075 1.7e-115 Protein RFT1 homolog OS=Drosophila melanogaster GN=CG3149 PE=2 SV=1 PF04506//PF01384 Rft protein//Phosphate transporter family GO:0006817//GO:0006869 phosphate ion transport//lipid transport GO:0005319//GO:0005315 lipid transporter activity//inorganic phosphate transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.27132 BP_3 5.77 0.52 825 820805582 AKG92782.1 139 4.1e-06 Pxs [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27134 BP_3 33.65 1.99 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.27136 BP_3 28.14 0.38 3853 270010252 EFA06700.1 399 1.4e-35 hypothetical protein TcasGA2_TC009631 [Tribolium castaneum] 5852161 AJ249388.1 65 1.28676e-22 Manduca sexta mRNA for vacuolar ATPase subunit C (mvC gene) K02148 ATPeV1C, ATP6C V-type H+-transporting ATPase subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K02148 Q9V7N5 364 6.4e-33 V-type proton ATPase subunit C OS=Drosophila melanogaster GN=Vha44 PE=2 SV=5 PF03223//PF12763 V-ATPase subunit C//Cytoskeletal-regulatory complex EF hand GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078//GO:0005515 hydrogen ion transmembrane transporter activity//protein binding GO:0033180 proton-transporting V-type ATPase, V1 domain KOG2909 Vacuolar H+-ATPase V1 sector, subunit C Cluster-8309.27139 BP_3 18.12 0.99 1172 332376146 AEE63213.1 517 8.5e-50 unknown [Dendroctonus ponderosae]>gi|478259623|gb|ENN79476.1| hypothetical protein YQE_04120, partial [Dendroctonus ponderosae]>gi|546679426|gb|ERL89890.1| hypothetical protein D910_07249 [Dendroctonus ponderosae] 815793034 XM_012361708.1 80 1.7588e-31 PREDICTED: Linepithema humile proteasome subunit alpha type-4 (LOC105668977), mRNA K02728 PSMA4 20S proteasome subunit alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02728 P21670 448 3.5e-43 Proteasome subunit alpha type-4 OS=Rattus norvegicus GN=Psma4 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0178 20S proteasome, regulatory subunit alpha type PSMA4/PRE9 Cluster-8309.2714 BP_3 14.00 0.83 1109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27143 BP_3 135.00 8.72 1038 91079592 XP_967810.1 678 1.6e-68 PREDICTED: transmembrane protein 223 [Tribolium castaneum]>gi|270003397|gb|EEZ99844.1| hypothetical protein TcasGA2_TC002625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DC58 304 1.6e-26 Transmembrane protein 223 OS=Danio rerio GN=tmem223 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27145 BP_3 2437.57 28.21 4457 642920612 XP_008192488.1 986 1.3e-103 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08777//PF02214 RNA binding motif//BTB/POZ domain GO:0051260 protein homooligomerization GO:0003723 RNA binding -- -- -- -- Cluster-8309.27147 BP_3 54.82 0.58 4857 -- -- -- -- -- 642912444 XM_008202641.1 328 1.02333e-168 PREDICTED: Tribolium castaneum serum response factor (Srf), transcript variant X1, mRNA K04378 SRF serum response factor http://www.genome.jp/dbget-bin/www_bget?ko:K04378 Q3SXZ3 139 9.9e-07 Zinc finger protein 718 OS=Homo sapiens GN=ZNF718 PE=2 SV=1 PF13912//PF00319//PF00096//PF13465 C2H2-type zinc finger//SRF-type transcription factor (DNA-binding and dimerisation domain)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0046983//GO:0003677 metal ion binding//protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.2715 BP_3 3.56 0.37 760 675366625 KFM59527.1 278 2.9e-22 Transposable element Tcb2 transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27150 BP_3 449.00 13.57 1886 91080201 XP_971515.1 1535 1.2e-167 PREDICTED: serine/threonine-protein kinase RIO1 [Tribolium castaneum]>gi|270005675|gb|EFA02123.1| hypothetical protein TcasGA2_TC007772 [Tribolium castaneum] 765148024 XM_004078884.2 59 1.35113e-19 PREDICTED: Oryzias latipes RIO kinase 1 (riok1), mRNA K07178 RIOK1 RIO kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07178 Q9BRS2 1042 7.5e-112 Serine/threonine-protein kinase RIO1 OS=Homo sapiens GN=RIOK1 PE=1 SV=2 PF09266 Viral DNA topoisomerase I, N-terminal GO:0006265 DNA topological change GO:0016301//GO:0003677//GO:0000166//GO:0003916 kinase activity//DNA binding//nucleotide binding//DNA topoisomerase activity -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.27151 BP_3 17.49 0.65 1594 642929512 XP_975068.2 1055 4.8e-112 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Tribolium castaneum] 727003473 XM_010393578.1 39 1.49306e-08 PREDICTED: Corvus cornix cornix 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA K01082 cysQ, MET22, BPNT1 3'(2'), 5'-bisphosphate nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01082 O95861 725 3.6e-75 3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens GN=BPNT1 PE=1 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.27154 BP_3 3.00 0.80 472 642914485 XP_008201694.1 168 1.0e-09 PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|642914487|ref|XP_008201695.1| PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|270001489|gb|EEZ97936.1| hypothetical protein TcasGA2_TC000324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27155 BP_3 703.57 15.60 2466 642914485 XP_008201694.1 673 1.5e-67 PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|642914487|ref|XP_008201695.1| PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|270001489|gb|EEZ97936.1| hypothetical protein TcasGA2_TC000324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BL31 320 5.2e-28 Uncharacterized protein C6orf106 homolog OS=Danio rerio GN=zgc:101577 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27156 BP_3 56.43 22.79 410 642914485 XP_008201694.1 317 4.6e-27 PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|642914487|ref|XP_008201695.1| PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|270001489|gb|EEZ97936.1| hypothetical protein TcasGA2_TC000324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BL31 177 3.3e-12 Uncharacterized protein C6orf106 homolog OS=Danio rerio GN=zgc:101577 PE=2 SV=1 PF03943 TAP C-terminal domain GO:0051028 mRNA transport -- -- GO:0005634 nucleus -- -- Cluster-8309.27160 BP_3 118.00 2.87 2271 642920486 XP_008192371.1 1180 2.2e-126 PREDICTED: testis-specific serine/threonine-protein kinase 1-like [Tribolium castaneum]>gi|270005224|gb|EFA01672.1| hypothetical protein TcasGA2_TC007244 [Tribolium castaneum] -- -- -- -- -- K08811 TSSK, STK22 testis-specific serine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08811 Q3SZW1 562 4.1e-56 Testis-specific serine/threonine-protein kinase 1 OS=Bos taurus GN=TSSK1B PE=2 SV=1 PF01193//PF06293//PF00069//PF07714 RNA polymerase Rpb3/Rpb11 dimerisation domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0006351 protein phosphorylation//transcription, DNA-templated GO:0046983//GO:0004672//GO:0005524//GO:0016773 protein dimerization activity//protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0583 Serine/threonine protein kinase Cluster-8309.27162 BP_3 14.52 0.31 2544 270011827 EFA08275.1 1674 1.3e-183 hypothetical protein TcasGA2_TC005909 [Tribolium castaneum] -- -- -- -- -- K15332 TRMT2A tRNA (uracil-5-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15332 Q8IZ69 966 6.6e-103 tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 PF00076//PF05401//PF01209//PF03602//PF05958//PF09445//PF02384//PF01135//PF05175//PF08241//PF02390 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Nodulation protein S (NodS)//ubiE/COQ5 methyltransferase family//Conserved hypothetical protein 95//tRNA (Uracil-5-)-methyltransferase//RNA cap guanine-N2 methyltransferase//N-6 DNA Methylase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Methyltransferase domain//Putative methyltransferase GO:0009312//GO:0006464//GO:0031167//GO:0008033//GO:0006396//GO:0001510//GO:0008152//GO:0009452//GO:0006479//GO:0009451//GO:0009877//GO:0046500//GO:0006306//GO:0006400 oligosaccharide biosynthetic process//cellular protein modification process//rRNA methylation//tRNA processing//RNA processing//RNA methylation//metabolic process//7-methylguanosine RNA capping//protein methylation//RNA modification//nodulation//S-adenosylmethionine metabolic process//DNA methylation//tRNA modification GO:0008170//GO:0008168//GO:0003677//GO:0008757//GO:0008173//GO:0008176//GO:0003676//GO:0004719 N-methyltransferase activity//methyltransferase activity//DNA binding//S-adenosylmethionine-dependent methyltransferase activity//RNA methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//nucleic acid binding//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity -- -- KOG2187 tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes Cluster-8309.27163 BP_3 103.67 1.54 3535 91090842 XP_972243.1 1069 2.5e-113 PREDICTED: large neutral amino acids transporter small subunit 1 [Tribolium castaneum]>gi|270013246|gb|EFA09694.1| hypothetical protein TcasGA2_TC011826 [Tribolium castaneum] 642935933 XM_967150.2 311 2.09446e-159 PREDICTED: Tribolium castaneum large neutral amino acids transporter small subunit 1 (LOC660956), mRNA K03450 SLC7A solute carrier family 7 (L-type amino acid transporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K03450 Q7YQK4 638 9.9e-65 Large neutral amino acids transporter small subunit 1 OS=Oryctolagus cuniculus GN=SLC7A5 PE=1 SV=1 PF00324//PF13520//PF04116//PF01384 Amino acid permease//Amino acid permease//Fatty acid hydroxylase superfamily//Phosphate transporter family GO:0006865//GO:0006633//GO:0055085//GO:0006817//GO:0006810//GO:0003333//GO:0055114 amino acid transport//fatty acid biosynthetic process//transmembrane transport//phosphate ion transport//transport//amino acid transmembrane transport//oxidation-reduction process GO:0015171//GO:0016491//GO:0005315//GO:0005506 amino acid transmembrane transporter activity//oxidoreductase activity//inorganic phosphate transmembrane transporter activity//iron ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1287 Amino acid transporters Cluster-8309.27164 BP_3 74.00 0.72 5214 478255334 ENN75560.1 280 1.2e-21 hypothetical protein YQE_07903, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0007186//GO:0006950 G-protein coupled receptor signaling pathway//response to stress GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.27165 BP_3 3.82 1.01 474 642919443 XP_974536.2 405 3.3e-37 PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum]>gi|642919445|ref|XP_008191871.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum] 768444263 XM_011565674.1 113 3.08722e-50 PREDICTED: Plutella xylostella putative ATP-dependent RNA helicase me31b (LOC105393859), mRNA K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 365 6.0e-34 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0326 ATP-dependent RNA helicase Cluster-8309.27170 BP_3 177.46 5.45 1862 642911933 XP_008199027.1 769 8.2e-79 PREDICTED: transmembrane protein 199 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N511 221 1.2e-16 Transmembrane protein 199 OS=Homo sapiens GN=TMEM199 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27171 BP_3 19.40 17.82 337 642911935 XP_008199028.1 315 6.5e-27 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 5-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZK77 131 5.8e-07 Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Gallus gallus GN=BLOC1S5 PE=2 SV=1 PF00558//PF14942 Vpu protein//Organelle biogenesis, Muted-like protein GO:0032801//GO:0019076//GO:0006812 receptor catabolic process//viral release from host cell//cation transport GO:0005261 cation channel activity GO:0031083//GO:0033644//GO:0030133 BLOC-1 complex//host cell membrane//transport vesicle -- -- Cluster-8309.27172 BP_3 15.00 1.66 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27175 BP_3 73.38 1.44 2753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27177 BP_3 681.00 20.76 1873 642912716 XP_008200973.1 517 1.4e-49 PREDICTED: uncharacterized protein LOC103315050 [Tribolium castaneum]>gi|270002368|gb|EEZ98815.1| hypothetical protein TcasGA2_TC004421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27178 BP_3 9.64 0.39 1475 642934633 XP_008197745.1 291 1.7e-23 PREDICTED: syntaxin-1A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05008//PF03811//PF07743//PF00804 Vesicle transport v-SNARE protein N-terminus//InsA N-terminal domain//HSCB C-terminal oligomerisation domain//Syntaxin GO:0051259//GO:0006886//GO:0006313 protein oligomerization//intracellular protein transport//transposition, DNA-mediated -- -- GO:0016020 membrane -- -- Cluster-8309.27179 BP_3 221.19 12.52 1143 642934633 XP_008197745.1 633 2.9e-63 PREDICTED: syntaxin-1A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24547 317 5.3e-28 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF05531//PF04111//PF00435//PF03811//PF07463//PF00804//PF00512//PF05008//PF05739 Nucleopolyhedrovirus P10 protein//Autophagy protein Apg6//Spectrin repeat//InsA N-terminal domain//NUMOD4 motif//Syntaxin//His Kinase A (phospho-acceptor) domain//Vesicle transport v-SNARE protein N-terminus//SNARE domain GO:0006914//GO:0006313//GO:0016310//GO:0006886//GO:0007165//GO:0000160 autophagy//transposition, DNA-mediated//phosphorylation//intracellular protein transport//signal transduction//phosphorelay signal transduction system GO:0005515//GO:0000155//GO:0016788 protein binding//phosphorelay sensor kinase activity//hydrolase activity, acting on ester bonds GO:0016020//GO:0009365//GO:0019028 membrane//protein histidine kinase complex//viral capsid KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.2718 BP_3 562.00 15.62 2026 642922078 XP_968360.2 395 2.1e-35 PREDICTED: cuticle protein 19 [Tribolium castaneum]>gi|270007259|gb|EFA03707.1| hypothetical protein TcasGA2_TC013812 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 329 3.8e-29 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.27181 BP_3 1043.54 29.24 2012 478262704 ENN81251.1 2158 7.6e-240 hypothetical protein YQE_02345, partial [Dendroctonus ponderosae]>gi|546679053|gb|ERL89576.1| hypothetical protein D910_06941 [Dendroctonus ponderosae] 759080227 XM_011351649.1 232 9.75278e-116 PREDICTED: Cerapachys biroi uncharacterized LOC105286595 (LOC105286595), transcript variant X5, mRNA K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 P70182 1209 3.5e-131 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Mus musculus GN=Pip5k1a PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.27184 BP_3 22.92 0.55 2286 270010381 EFA06829.1 868 3.3e-90 hypothetical protein TcasGA2_TC009771 [Tribolium castaneum] -- -- -- -- -- K14782 AATF, BFR2 protein AATF/BFR2 http://www.genome.jp/dbget-bin/www_bget?ko:K14782 Q5ZIM6 527 4.7e-52 Protein AATF OS=Gallus gallus GN=AATF PE=2 SV=1 PF08164//PF04410 Apoptosis-antagonizing transcription factor, C-terminal//Gar1/Naf1 RNA binding region GO:0042254//GO:0001522 ribosome biogenesis//pseudouridine synthesis -- -- GO:0005634 nucleus KOG2773 Apoptosis antagonizing transcription factor/protein transport protein Cluster-8309.27185 BP_3 489.28 35.72 952 91078236 XP_966494.1 759 6.0e-78 PREDICTED: ras-related protein Rab-21 [Tribolium castaneum]>gi|270003941|gb|EFA00389.1| hypothetical protein TcasGA2_TC003235 [Tribolium castaneum] -- -- -- -- -- K07890 RAB21 Ras-related protein Rab-21 http://www.genome.jp/dbget-bin/www_bget?ko:K07890 P55745 689 3.2e-71 Ras-related protein Rab-21 OS=Canis familiaris GN=RAB21 PE=3 SV=3 PF03193//PF00107//PF04670//PF10662//PF00071//PF08477//PF01926//PF00025 Protein of unknown function, DUF258//Zinc-binding dehydrogenase//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family GO:0007264//GO:0055114//GO:0015031//GO:0006576 small GTPase mediated signal transduction//oxidation-reduction process//protein transport//cellular biogenic amine metabolic process GO:0003924//GO:0005525//GO:0005524 GTPase activity//GTP binding//ATP binding -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.27188 BP_3 4.00 1.27 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27191 BP_3 1.00 4.87 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27192 BP_3 23.18 0.68 1935 -- -- -- -- -- 462313076 APGK01046348.1 42 3.91105e-10 Dendroctonus ponderosae Seq01046358, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27196 BP_3 1231.79 10.96 5708 642914968 XP_008190463.1 2570 3.6e-287 PREDICTED: kelch-like protein 5 [Tribolium castaneum] 701432439 XM_010006117.1 50 4.16835e-14 PREDICTED: Chaetura pelagica kelch-like family member 5 (KLHL5), transcript variant X3, mRNA K10442 KLHL1_4_5 kelch-like protein 1/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10442 Q96PQ7 1663 2.2e-183 Kelch-like protein 5 OS=Homo sapiens GN=KLHL5 PE=2 SV=3 PF03931//PF01344//PF10576//PF07646//PF00651 Skp1 family, tetramerisation domain//Kelch motif//Iron-sulfur binding domain of endonuclease III//Kelch motif//BTB/POZ domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515//GO:0051539 protein binding//4 iron, 4 sulfur cluster binding -- -- -- -- Cluster-8309.272 BP_3 1.00 0.34 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27202 BP_3 583.40 7.55 4017 91079024 XP_974902.1 614 1.7e-60 PREDICTED: methyltransferase-like protein 10 [Tribolium castaneum]>gi|642916302|ref|XP_008190967.1| PREDICTED: methyltransferase-like protein 10 [Tribolium castaneum]>gi|642916304|ref|XP_008190968.1| PREDICTED: methyltransferase-like protein 10 [Tribolium castaneum]>gi|270004177|gb|EFA00625.1| hypothetical protein TcasGA2_TC003501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D853 438 1.7e-41 Protein-lysine N-methyltransferase Mettl10 OS=Mus musculus GN=Mettl10 PE=2 SV=1 PF05958//PF02005//PF01234//PF08241//PF02390//PF05724//PF01135//PF05175//PF05401//PF07757 tRNA (Uracil-5-)-methyltransferase//N2,N2-dimethylguanosine tRNA methyltransferase//NNMT/PNMT/TEMT family//Methyltransferase domain//Putative methyltransferase//Thiopurine S-methyltransferase (TPMT)//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Nodulation protein S (NodS)//Predicted AdoMet-dependent methyltransferase GO:0008033//GO:0006396//GO:0009312//GO:0006464//GO:0046500//GO:0006400//GO:0006479//GO:0009451//GO:0009877//GO:0008152 tRNA processing//RNA processing//oligosaccharide biosynthetic process//cellular protein modification process//S-adenosylmethionine metabolic process//tRNA modification//protein methylation//RNA modification//nodulation//metabolic process GO:0004809//GO:0008168//GO:0004719//GO:0008176//GO:0008173//GO:0008757//GO:0003723 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//RNA methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//RNA binding -- -- KOG1271 Methyltransferases Cluster-8309.27203 BP_3 7.95 0.51 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27204 BP_3 774.61 9.38 4274 282158073 NP_001164080.1 2197 4.9e-244 saxophone precursor [Tribolium castaneum] -- -- -- -- -- K04675 ACVR1, ALK2 activin receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04675 P80201 1388 1.3e-151 Activin receptor type-1 OS=Rattus norvegicus GN=Acvr1 PE=2 SV=1 PF07714//PF01064//PF00069//PF08515//PF00087 Protein tyrosine kinase//Activin types I and II receptor domain//Protein kinase domain//Transforming growth factor beta type I GS-motif//Snake toxin GO:0007178//GO:0009405//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//pathogenesis//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004675//GO:0004672 ATP binding//transmembrane receptor protein serine/threonine kinase activity//protein kinase activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.27207 BP_3 5.00 0.89 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27208 BP_3 1439.79 67.16 1325 270008647 EFA05095.1 862 9.5e-90 hypothetical protein TcasGA2_TC015194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VBV3 286 2.4e-24 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27209 BP_3 19.45 0.40 2611 270008906 EFA05354.1 2417 9.2e-270 hypothetical protein TcasGA2_TC015519 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2057 2.1e-229 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654//PF00087//PF02934 Voltage gated chloride channel//Snake toxin//GatB/GatE catalytic domain GO:0006821//GO:0009405//GO:0055085 chloride transport//pathogenesis//transmembrane transport GO:0016874//GO:0005247 ligase activity//voltage-gated chloride channel activity GO:0005576//GO:0016020 extracellular region//membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.2721 BP_3 52.35 3.92 935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27210 BP_3 384.74 3.27 5957 642920179 XP_008192235.1 324 1.0e-26 PREDICTED: uncharacterized protein LOC103312687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04976//PF14972 DMSO reductase anchor subunit (DmsC)//Mitochondrial morphogenesis regulator GO:0019645//GO:0007005 anaerobic electron transport chain//mitochondrion organization -- -- GO:0016021//GO:0031305 integral component of membrane//integral component of mitochondrial inner membrane -- -- Cluster-8309.27212 BP_3 36.89 0.79 2534 642931119 XP_008201669.1 700 1.1e-70 PREDICTED: autism susceptibility gene 2 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00376 MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.27213 BP_3 86.23 0.84 5246 189233955 XP_967484.2 1368 8.0e-148 PREDICTED: uncharacterized protein LOC655828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-8309.27214 BP_3 189.00 2.04 4748 642923524 XP_008193545.1 3325 0.0e+00 PREDICTED: anoctamin-5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q32M45 1455 2.4e-159 Anoctamin-4 OS=Homo sapiens GN=ANO4 PE=2 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- KOG2514 Uncharacterized conserved protein Cluster-8309.27215 BP_3 4112.00 60.27 3580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27217 BP_3 518.00 68.54 656 91088959 XP_973975.1 325 8.8e-28 PREDICTED: ragulator complex protein LAMTOR4 homolog [Tribolium castaneum]>gi|270012374|gb|EFA08822.1| hypothetical protein TcasGA2_TC006518 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VZL6 218 9.2e-17 Ragulator complex protein LAMTOR4 homolog OS=Drosophila melanogaster GN=CG14977 PE=1 SV=2 PF16672 Ragulator complex protein LAMTOR5 GO:0043154//GO:0043066//GO:0019079 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//negative regulation of apoptotic process//viral genome replication -- -- GO:0005737//GO:0071986 cytoplasm//Ragulator complex -- -- Cluster-8309.27220 BP_3 2938.62 57.90 2738 189237377 XP_971339.2 1363 1.6e-147 PREDICTED: X-linked interleukin-1 receptor accessory protein-like 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13591 158 3.5e-09 Neural cell adhesion molecule 1 OS=Homo sapiens GN=NCAM1 PE=1 SV=3 PF01582//PF13676//PF13895 TIR domain//TIR domain//Immunoglobulin domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.27221 BP_3 394.92 9.27 2345 270001585 EEZ98032.1 339 7.5e-29 hypothetical protein TcasGA2_TC000433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27222 BP_3 193.42 2.79 3635 642919133 XP_008191750.1 205 4.0e-13 PREDICTED: tetratricopeptide repeat protein 18-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03176//PF13414//PF02780//PF13181//PF12235 MMPL family//TPR repeat//Transketolase, C-terminal domain//Tetratricopeptide repeat//Fragile X-related 1 protein core C terminal GO:0008152 metabolic process GO:0005515//GO:0003723//GO:0003824 protein binding//RNA binding//catalytic activity GO:0016020 membrane -- -- Cluster-8309.27223 BP_3 307.58 5.36 3056 642919133 XP_008191750.1 395 3.1e-35 PREDICTED: tetratricopeptide repeat protein 18-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0N1 173 7.1e-11 Cilia- and flagella-associated protein 70 OS=Homo sapiens GN=CFAP70 PE=2 SV=3 PF13414//PF03176//PF12235//PF02780//PF00515//PF13181 TPR repeat//MMPL family//Fragile X-related 1 protein core C terminal//Transketolase, C-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0008152 metabolic process GO:0005515//GO:0003824//GO:0003723 protein binding//catalytic activity//RNA binding GO:0016020 membrane -- -- Cluster-8309.27224 BP_3 2803.37 85.94 1864 642920046 XP_975305.2 1015 2.4e-107 PREDICTED: kielin/chordin-like protein [Tribolium castaneum]>gi|270005328|gb|EFA01776.1| hypothetical protein TcasGA2_TC007377 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28178 135 1.1e-06 Thrombospondin-1 OS=Bos taurus GN=THBS1 PE=2 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.27226 BP_3 156.66 1.19 6627 642935213 XP_008199692.1 1371 4.5e-148 PREDICTED: RNA-binding protein Musashi homolog Rbp6 isoform X2 [Tribolium castaneum] 642935212 XM_008201470.1 619 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog Rbp6 (LOC656553), transcript variant X2, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q9VVE5 1020 9.4e-109 RNA-binding protein Musashi homolog Rbp6 OS=Drosophila melanogaster GN=Rbp6 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.27227 BP_3 672.43 4.69 7204 642935221 XP_008199697.1 1816 1.2e-199 PREDICTED: RNA-binding protein Musashi homolog Rbp6 isoform X6 [Tribolium castaneum] 642935220 XM_008201475.1 846 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog Rbp6 (LOC656553), transcript variant X6, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q9VVE5 1513 7.0e-166 RNA-binding protein Musashi homolog Rbp6 OS=Drosophila melanogaster GN=Rbp6 PE=2 SV=3 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.27229 BP_3 683.55 6.23 5584 91078256 XP_970842.1 4504 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 558207907 XM_006132981.1 93 5.09092e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2891 0.0e+00 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF05743//PF05773//PF03810 UEV domain//RWD domain//Importin-beta N-terminal domain GO:0006886//GO:0015031//GO:0006464 intracellular protein transport//protein transport//cellular protein modification process GO:0005515//GO:0008536//GO:0008565 protein binding//Ran GTPase binding//protein transporter activity GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.2723 BP_3 3.00 0.86 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27230 BP_3 4.00 0.63 598 478257606 ENN77758.1 155 4.1e-08 hypothetical protein YQE_05730, partial [Dendroctonus ponderosae]>gi|546677510|gb|ERL88336.1| hypothetical protein D910_05723 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27232 BP_3 36.05 0.54 3538 642917446 XP_008191203.1 2066 6.2e-229 PREDICTED: maternal protein tudor isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25823 382 4.8e-35 Maternal protein tudor OS=Drosophila melanogaster GN=tud PE=1 SV=2 PF06003 Survival motor neuron protein (SMN) GO:0006397 mRNA processing GO:0003723 RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.27233 BP_3 69.48 1.02 3582 642922865 XP_008200429.1 2031 7.2e-225 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum]>gi|642922867|ref|XP_008200430.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1465 1.3e-160 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF01926//PF13304//PF00664//PF12844//PF00236 Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Helix-turn-helix domain//Glycoprotein hormone GO:0055085//GO:0007165//GO:0006810 transmembrane transport//signal transduction//transport GO:0016887//GO:0043565//GO:0005525//GO:0042626//GO:0005524//GO:0003924//GO:0005179 ATPase activity//sequence-specific DNA binding//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.27234 BP_3 215.05 1.61 6740 642910889 XP_008193451.1 3859 0.0e+00 PREDICTED: SLIT-ROBO Rho GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] 805778458 XM_012283126.1 285 1.13915e-144 PREDICTED: Megachile rotundata SLIT-ROBO Rho GTPase-activating protein 1 (LOC100883803), transcript variant X1, mRNA K07526 SRGAP SLIT-ROBO Rho GTPase activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K07526 Q7Z6B7 1641 9.4e-181 SLIT-ROBO Rho GTPase-activating protein 1 OS=Homo sapiens GN=SRGAP1 PE=1 SV=1 PF02321//PF16740//PF00620//PF14604//PF00018 Outer membrane efflux protein//Spindle and kinetochore-associated protein 2//RhoGAP domain//Variant SH3 domain//SH3 domain GO:0006810//GO:0007165//GO:0007059//GO:0007067//GO:0000090//GO:0031110//GO:0051301 transport//signal transduction//chromosome segregation//mitotic nuclear division//mitotic anaphase//regulation of microtubule polymerization or depolymerization//cell division GO:0005215//GO:0005515//GO:0008017 transporter activity//protein binding//microtubule binding GO:0045298//GO:0005876//GO:0000940 tubulin complex//spindle microtubule//condensed chromosome outer kinetochore -- -- Cluster-8309.27237 BP_3 10.46 4.00 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27238 BP_3 128.06 2.44 2822 817087360 XP_012266451.1 2016 3.1e-223 PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae]>gi|817087362|ref|XP_012266452.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae] 158299880 XM_319893.4 460 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1902 2.1e-211 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF00270//PF00096//PF08168//PF06221//PF08057 DEAD/DEAH box helicase//Zinc finger, C2H2 type//NUC205 domain//Putative zinc finger motif, C2HC5-type//Erythromycin resistance leader peptide GO:0046677//GO:0006355 response to antibiotic//regulation of transcription, DNA-templated GO:0046872//GO:0003676//GO:0005524//GO:0008270 metal ion binding//nucleic acid binding//ATP binding//zinc ion binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.27239 BP_3 678.10 8.65 4072 642931762 XP_008196718.1 2808 0.0e+00 PREDICTED: exocyst complex component 7 [Tribolium castaneum]>gi|270011742|gb|EFA08190.1| hypothetical protein TcasGA2_TC005817 [Tribolium castaneum] -- -- -- -- -- K07195 EXOC7, EXO70 exocyst complex component 7 http://www.genome.jp/dbget-bin/www_bget?ko:K07195 Q9VSJ8 1391 5.5e-152 Exocyst complex component 7 OS=Drosophila melanogaster GN=exo70 PE=1 SV=2 PF00700//PF03081//PF02214//PF10392 Bacterial flagellin C-terminal helical region//Exo70 exocyst complex subunit//BTB/POZ domain//Golgi transport complex subunit 5 GO:0051260//GO:0071973//GO:0006891//GO:0006887 protein homooligomerization//bacterial-type flagellum-dependent cell motility//intra-Golgi vesicle-mediated transport//exocytosis GO:0005198 structural molecule activity GO:0000145//GO:0017119 exocyst//Golgi transport complex KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes Cluster-8309.27240 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27241 BP_3 169.59 6.87 1482 91078514 XP_969613.1 1034 1.2e-109 PREDICTED: mediator of RNA polymerase II transcription subunit 24 [Tribolium castaneum]>gi|270004025|gb|EFA00473.1| hypothetical protein TcasGA2_TC003332 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16X15 218 2.1e-16 Mediator of RNA polymerase II transcription subunit 24 OS=Aedes aegypti GN=MED24 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27245 BP_3 3050.55 54.35 2997 478256729 ENN76910.1 1408 1.1e-152 hypothetical protein YQE_06557, partial [Dendroctonus ponderosae]>gi|546672603|gb|ERL84404.1| hypothetical protein D910_01837 [Dendroctonus ponderosae] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 436 2.2e-41 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF00083//PF04848 Major Facilitator Superfamily//Sugar (and other) transporter//Poxvirus A22 protein GO:0006310//GO:0006281//GO:0055085 DNA recombination//DNA repair//transmembrane transport GO:0000287//GO:0016788//GO:0022857//GO:0000400 magnesium ion binding//hydrolase activity, acting on ester bonds//transmembrane transporter activity//four-way junction DNA binding GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.27246 BP_3 2.00 17.39 247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27247 BP_3 3.00 17.18 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27250 BP_3 208.91 6.10 1943 642915754 XP_008200067.1 463 2.6e-43 PREDICTED: sprouty-related protein with EVH-1 domain isoform X1 [Tribolium castaneum] 642915753 XM_008201845.1 203 1.24369e-99 PREDICTED: Tribolium castaneum sprouty-related protein with EVH-1 domain (Spred), transcript variant X1, mRNA K04703 SPRED sprouty-related, EVH1 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04703 Q66JG9 272 1.5e-22 Sprouty-related, EVH1 domain-containing protein 1 OS=Xenopus tropicalis GN=spred1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27251 BP_3 157.00 7.31 1327 -- -- -- -- -- 689566069 LM032164.1 34 7.44694e-06 Soboliphyme baturini genome assembly S_baturini_Dall_Island ,scaffold SBAD_contig0003591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27252 BP_3 812.00 45.65 1149 91083777 XP_972333.1 572 3.5e-56 PREDICTED: mitochondrial fission 1 protein [Tribolium castaneum]>gi|270007915|gb|EFA04363.1| hypothetical protein TcasGA2_TC014659 [Tribolium castaneum] -- -- -- -- -- K17969 FIS1, TTC11, MDV2 mitochondrial fission 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K17969 Q9Y3D6 315 9.1e-28 Mitochondrial fission 1 protein OS=Homo sapiens GN=FIS1 PE=1 SV=2 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0016818//GO:0005524//GO:0003676 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//nucleic acid binding GO:0005634 nucleus KOG3364 Membrane protein involved in organellar division Cluster-8309.27253 BP_3 38.30 2.47 1039 91090728 XP_966926.1 287 3.5e-23 PREDICTED: uncharacterized protein LOC655305 isoform X2 [Tribolium castaneum]>gi|270013951|gb|EFA10399.1| hypothetical protein TcasGA2_TC012638 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.27254 BP_3 280.69 16.43 1115 91090728 XP_966926.1 405 7.9e-37 PREDICTED: uncharacterized protein LOC655305 isoform X2 [Tribolium castaneum]>gi|270013951|gb|EFA10399.1| hypothetical protein TcasGA2_TC012638 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.27259 BP_3 69.10 11.67 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2726 BP_3 9.28 0.44 1312 270003621 EFA00069.1 1316 2.1e-142 hypothetical protein TcasGA2_TC002883 [Tribolium castaneum] 642916526 XM_008192857.1 294 2.15627e-150 PREDICTED: Tribolium castaneum glutamate receptor ionotropic, kainate 2-like (LOC655107), mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P42260 789 1.1e-82 Glutamate receptor ionotropic, kainate 2 OS=Rattus norvegicus GN=Grik2 PE=1 SV=2 PF00060 Ligand-gated ion channel GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0004970 ionotropic glutamate receptor activity GO:0016020 membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-8309.27264 BP_3 742.96 5.47 6835 642935636 XP_008198092.1 4462 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 5.45165e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.0e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF00595//PF00620//PF13180//PF08718 PDZ domain (Also known as DHR or GLGF)//RhoGAP domain//PDZ domain//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0051861//GO:0017089//GO:0005515 glycolipid binding//glycolipid transporter activity//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.27265 BP_3 258.90 9.83 1561 270001097 EEZ97544.1 1487 3.8e-162 hypothetical protein TcasGA2_TC011394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27266 BP_3 1.24 2.45 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27267 BP_3 13.18 0.83 1058 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27271 BP_3 8.89 0.63 968 189240236 XP_001811057.1 779 2.9e-80 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 53 1.47624e-16 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q7ZYD5 532 5.3e-53 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Xenopus laevis GN=slc25a25 PE=2 SV=1 PF00451 Scorpion short toxin, BmKK2 GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region KOG0036 Predicted mitochondrial carrier protein Cluster-8309.27273 BP_3 6.01 0.58 790 568259248 ETN67215.1 402 1.2e-36 hypothetical protein AND_000981 [Anopheles darlingi] 551493589 XM_005798306.1 116 1.13717e-51 PREDICTED: Xiphophorus maculatus calmodulin-like (LOC102227246), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 Q95NR9 369 3.4e-34 Calmodulin OS=Metridium senile PE=1 SV=3 PF12763//PF10591//PF13405//PF13833//PF13499//PF02627//PF13202//PF00036 Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF-hand domain pair//Carboxymuconolactone decarboxylase family//EF hand//EF hand GO:0055114//GO:0007165 oxidation-reduction process//signal transduction GO:0005515//GO:0051920//GO:0005509 protein binding//peroxiredoxin activity//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.27274 BP_3 34.00 1.17 1698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27275 BP_3 8.86 0.41 1326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27276 BP_3 136.31 1.12 6146 642915402 XP_008190599.1 1753 2.1e-192 PREDICTED: nocturnin isoform X1 [Tribolium castaneum] -- -- -- -- -- K18764 CCRN4L nocturnin http://www.genome.jp/dbget-bin/www_bget?ko:K18764 Q9UK39 748 3.0e-77 Nocturnin OS=Homo sapiens GN=CCRN4L PE=2 SV=2 PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GO:0006633//GO:0006090 fatty acid biosynthetic process//pyruvate metabolic process GO:0003989 acetyl-CoA carboxylase activity GO:0009317 acetyl-CoA carboxylase complex KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.27278 BP_3 2000.68 46.62 2360 91079354 XP_969967.1 2114 1.1e-234 PREDICTED: eukaryotic translation initiation factor 3 subunit E [Tribolium castaneum]>gi|270003495|gb|EEZ99942.1| hypothetical protein TcasGA2_TC002738 [Tribolium castaneum] 820854748 XM_012489206.1 281 6.61599e-143 PREDICTED: Apis florea eukaryotic translation initiation factor 3 subunit E (LOC100869754), transcript variant X2, mRNA K03250 EIF3E, INT6 translation initiation factor 3 subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K03250 Q2F5R8 1688 1.2e-186 Eukaryotic translation initiation factor 3 subunit E OS=Bombyx mori GN=eIF3-S6 PE=2 SV=1 PF01399 PCI domain GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0005515//GO:0003743 protein binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG2758 Translation initiation factor 3, subunit e (eIF-3e) Cluster-8309.27285 BP_3 1636.86 46.18 2000 91079642 XP_968121.1 1922 1.8e-212 PREDICTED: vacuolar protein sorting-associated protein 4B [Tribolium castaneum]>gi|270004475|gb|EFA00923.1| hypothetical protein TcasGA2_TC003829 [Tribolium castaneum] 346710885 AK385938.1 304 9.1602e-156 Bombyx mori mRNA, clone: fphe14F12 K12196 VPS4 vacuolar protein-sorting-associated protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12196 Q9UN37 1614 3.7e-178 Vacuolar protein sorting-associated protein 4A OS=Homo sapiens GN=VPS4A PE=1 SV=1 PF07724//PF00004//PF04889//PF05496//PF00158//PF13304//PF06068//PF01695//PF14532//PF07728//PF00910//PF13414//PF02562//PF01637 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Cwf15/Cwc15 cell cycle control protein//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//TIP49 C-terminus//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//RNA helicase//TPR repeat//PhoH-like protein//Archaeal ATPase GO:0006310//GO:0006281//GO:0000398//GO:0006355 DNA recombination//DNA repair//mRNA splicing, via spliceosome//regulation of transcription, DNA-templated GO:0005515//GO:0003678//GO:0003723//GO:0017111//GO:0009378//GO:0003724//GO:0008134//GO:0005524//GO:0016887 protein binding//DNA helicase activity//RNA binding//nucleoside-triphosphatase activity//four-way junction helicase activity//RNA helicase activity//transcription factor binding//ATP binding//ATPase activity GO:0005681//GO:0005667//GO:0005657//GO:0009379 spliceosomal complex//transcription factor complex//replication fork//Holliday junction helicase complex KOG0739 AAA+-type ATPase Cluster-8309.27286 BP_3 8.00 1.56 539 662207644 XP_008477334.1 157 2.2e-08 PREDICTED: zinc finger protein 721-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF02176 Zinc-finger double domain//Zinc finger, C2H2 type//TRAF-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.27287 BP_3 889.17 18.96 2552 270013489 EFA09937.1 457 1.7e-42 hypothetical protein TcasGA2_TC012090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02687//PF01284 FtsX-like permease family//Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.27288 BP_3 166.57 5.25 1822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27289 BP_3 33.28 0.44 3900 91079999 XP_966589.1 1804 1.7e-198 PREDICTED: kelch domain-containing protein 4 [Tribolium castaneum]>gi|270003222|gb|EEZ99669.1| hypothetical protein TcasGA2_TC002426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q921I2 1056 3.7e-113 Kelch domain-containing protein 4 OS=Mus musculus GN=Klhdc4 PE=2 SV=2 PF01344//PF00096//PF13465//PF07646//PF13912 Kelch motif//Zinc finger, C2H2 type//Zinc-finger double domain//Kelch motif//C2H2-type zinc finger -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- KOG1230 Protein containing repeated kelch motifs Cluster-8309.2729 BP_3 1.00 9.36 245 390369787 XP_003731711.1 186 4.3e-12 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 143 1.7e-08 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27290 BP_3 483.15 10.38 2535 642933271 XP_008197352.1 668 5.7e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933272 XM_961737.3 247 5.65728e-124 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X2, mRNA -- -- -- -- Q65Z95 602 1.1e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.27292 BP_3 1411.40 11.35 6283 189241493 XP_967027.2 4503 0.0e+00 PREDICTED: ras GTPase-activating protein 1 [Tribolium castaneum]>gi|270001192|gb|EEZ97639.1| hypothetical protein TcasGA2_TC016087 [Tribolium castaneum] -- -- -- -- -- K04352 RASA1, RASGAP Ras GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04352 P50904 2049 4.3e-228 Ras GTPase-activating protein 1 OS=Rattus norvegicus GN=Rasa1 PE=3 SV=1 PF14604//PF00018//PF00168//PF00616 Variant SH3 domain//SH3 domain//C2 domain//GTPase-activator protein for Ras-like GTPase GO:0051056//GO:0043547//GO:0043087 regulation of small GTPase mediated signal transduction//positive regulation of GTPase activity//regulation of GTPase activity GO:0005096//GO:0005543//GO:0005515 GTPase activator activity//phospholipid binding//protein binding GO:0005622 intracellular KOG3508 GTPase-activating protein Cluster-8309.27295 BP_3 2048.09 35.82 3048 642928336 XP_008195540.1 2691 1.8e-301 PREDICTED: slit homolog 1 protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 294 6.6e-25 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27296 BP_3 8.00 1.87 498 -- -- -- -- -- 195964838 EU676338.1 96 9.17974e-41 Ocypode quadrata myosin heavy chain isoform 3 mRNA, partial cds -- -- -- -- -- -- -- -- PF00957//PF01576 Synaptobrevin//Myosin tail GO:0016192 vesicle-mediated transport GO:0003774 motor activity GO:0016021//GO:0016459 integral component of membrane//myosin complex -- -- Cluster-8309.27297 BP_3 88.90 1.12 4118 410509308 BAM65720.1 3886 0.0e+00 myosin heavy chain type 2 [Penaeus monodon] 343183154 AB613206.1 738 0 Marsupenaeus japonicus MYHb mRNA for myosin heavy chain type b, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 3776 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00612//PF01576//PF16716//PF00038 IQ calmodulin-binding motif//Myosin tail//Bone marrow stromal antigen 2//Intermediate filament protein GO:0051607 defense response to virus GO:0003774//GO:0005198//GO:0005515 motor activity//structural molecule activity//protein binding GO:0016459//GO:0005882 myosin complex//intermediate filament -- -- Cluster-8309.27298 BP_3 124.00 1.66 3898 410509308 BAM65720.1 3449 0.0e+00 myosin heavy chain type 2 [Penaeus monodon] 343183154 AB613206.1 552 0 Marsupenaeus japonicus MYHb mRNA for myosin heavy chain type b, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 3214 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF08702//PF00038//PF01576//PF00612//PF07926 Fibrinogen alpha/beta chain family//Intermediate filament protein//Myosin tail//IQ calmodulin-binding motif//TPR/MLP1/MLP2-like protein GO:0007165//GO:0051258//GO:0030168//GO:0006606 signal transduction//protein polymerization//platelet activation//protein import into nucleus GO:0005515//GO:0005198//GO:0003774//GO:0005102//GO:0030674 protein binding//structural molecule activity//motor activity//receptor binding//protein binding, bridging GO:0016459//GO:0005882//GO:0005577 myosin complex//intermediate filament//fibrinogen complex -- -- Cluster-8309.27299 BP_3 23.00 0.66 1981 410509312 BAM65722.1 1804 8.4e-199 myosin heavy chain type 2 [Litopenaeus vannamei] 37925238 AY232598.1 500 0 Homarus americanus slow muscle myosin S1 heavy chain mRNA, partial cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 1694 2.0e-187 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF06160//PF00523//PF08702//PF00038//PF04508//PF01576 Septation ring formation regulator, EzrA//Fusion glycoprotein F0//Fibrinogen alpha/beta chain family//Intermediate filament protein//Viral A-type inclusion protein repeat//Myosin tail GO:0000921//GO:0051258//GO:0016032//GO:0007165//GO:0006948//GO:0030168 septin ring assembly//protein polymerization//viral process//signal transduction//induction by virus of host cell-cell fusion//platelet activation GO:0005198//GO:0005102//GO:0003774//GO:0030674 structural molecule activity//receptor binding//motor activity//protein binding, bridging GO:0005940//GO:0005882//GO:0016459//GO:0016021//GO:0005577 septin ring//intermediate filament//myosin complex//integral component of membrane//fibrinogen complex -- -- Cluster-8309.27301 BP_3 24.01 0.42 3071 410509306 BAM65719.1 3021 0.0e+00 myosin heavy chain type 1 [Penaeus monodon] 37925238 AY232598.1 476 0 Homarus americanus slow muscle myosin S1 heavy chain mRNA, partial cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2828 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF10473//PF12844//PF01576//PF00038 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Helix-turn-helix domain//Myosin tail//Intermediate filament protein -- -- GO:0003774//GO:0043565//GO:0042803//GO:0045502//GO:0008134//GO:0005198 motor activity//sequence-specific DNA binding//protein homodimerization activity//dynein binding//transcription factor binding//structural molecule activity GO:0005882//GO:0005667//GO:0030286//GO:0016459 intermediate filament//transcription factor complex//dynein complex//myosin complex -- -- Cluster-8309.27302 BP_3 45.09 0.79 3058 410509306 BAM65719.1 2901 0.0e+00 myosin heavy chain type 1 [Penaeus monodon] 107098391 DQ534441.1 268 1.44874e-135 Ocypode quadrata myosin heavy chain isoform 2 mRNA, partial cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2731 1.7e-307 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00038//PF05046//PF16716//PF01576//PF06160//PF10473//PF07926 Intermediate filament protein//Mitochondrial large subunit ribosomal protein (Img2)//Bone marrow stromal antigen 2//Myosin tail//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein GO:0006412//GO:0000921//GO:0051607//GO:0042254//GO:0006606 translation//septin ring assembly//defense response to virus//ribosome biogenesis//protein import into nucleus GO:0003774//GO:0042803//GO:0045502//GO:0008134//GO:0005198//GO:0003735 motor activity//protein homodimerization activity//dynein binding//transcription factor binding//structural molecule activity//structural constituent of ribosome GO:0005667//GO:0030286//GO:0005940//GO:0005882//GO:0016459//GO:0016021//GO:0005622//GO:0005840 transcription factor complex//dynein complex//septin ring//intermediate filament//myosin complex//integral component of membrane//intracellular//ribosome -- -- Cluster-8309.27304 BP_3 82.02 2.01 2262 642921874 XP_008192925.1 1162 2.7e-124 PREDICTED: LIM domain-containing protein jub isoform X1 [Tribolium castaneum] 751784607 XM_011203301.1 69 4.48789e-25 PREDICTED: Bactrocera dorsalis LIM domain-containing protein jub (LOC105225003), mRNA K16682 AJUBA, LIMD1, WTIP LIM domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K16682 Q9VY77 432 4.9e-41 LIM domain-containing protein jub OS=Drosophila melanogaster GN=jub PE=1 SV=3 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.27306 BP_3 16.00 1.13 973 641672855 XP_008186090.1 179 1.1e-10 PREDICTED: transcription factor IIIA-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02701//PF13465//PF00096//PF05191 Dof domain, zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Adenylate kinase, active site lid GO:0006144//GO:0046034//GO:0006355 purine nucleobase metabolic process//ATP metabolic process//regulation of transcription, DNA-templated GO:0004017//GO:0046872//GO:0003677 adenylate kinase activity//metal ion binding//DNA binding -- -- -- -- Cluster-8309.27307 BP_3 598.01 29.28 1276 478262967 ENN81373.1 902 2.1e-94 hypothetical protein YQE_02190, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O16098 167 1.5e-10 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128 Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169 catalytic activity//cation binding -- -- -- -- Cluster-8309.27309 BP_3 42.07 0.55 3979 642935930 XP_008198233.1 4473 0.0e+00 PREDICTED: RRP12-like protein [Tribolium castaneum] 462473101 APGK01001802.1 98 6.01176e-41 Dendroctonus ponderosae Seq01001802, whole genome shotgun sequence K14794 RRP12 ribosomal RNA-processing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14794 Q5ZKD5 1815 3.7e-201 RRP12-like protein OS=Gallus gallus GN=RRP12 PE=2 SV=1 PF00552//PF01113//PF16782 Integrase DNA binding domain//Dihydrodipicolinate reductase, N-terminus//Nucleotide exchange factor SIL1 GO:0009089//GO:0009085//GO:0055114 lysine biosynthetic process via diaminopimelate//lysine biosynthetic process//oxidation-reduction process GO:0003676//GO:0000774//GO:0008839 nucleic acid binding//adenyl-nucleotide exchange factor activity//4-hydroxy-tetrahydrodipicolinate reductase GO:0005783 endoplasmic reticulum KOG1248 Uncharacterized conserved protein Cluster-8309.27310 BP_3 733.00 34.73 1309 91080019 XP_971957.1 514 2.1e-49 PREDICTED: uncharacterized protein LOC660651 isoform X1 [Tribolium castaneum]>gi|270003229|gb|EEZ99676.1| hypothetical protein TcasGA2_TC002433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00669//PF05051 Bacterial flagellin N-terminal helical region//Cytochrome C oxidase copper chaperone (COX17) GO:0006825//GO:0071973 copper ion transport//bacterial-type flagellum-dependent cell motility GO:0005198//GO:0016531//GO:0005507 structural molecule activity//copper chaperone activity//copper ion binding GO:0005758 mitochondrial intermembrane space -- -- Cluster-8309.27311 BP_3 27.79 0.50 2978 827556941 XP_012549781.1 867 5.7e-90 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27314 BP_3 258.92 2.17 6042 642911239 XP_008199721.1 3695 0.0e+00 PREDICTED: IQ motif and SEC7 domain-containing protein 1 isoform X1 [Tribolium castaneum] 641661643 XM_001945108.3 182 1.84679e-87 PREDICTED: Acyrthosiphon pisum IQ motif and SEC7 domain-containing protein 1 (LOC100162626), transcript variant X2, mRNA K12495 IQSEC IQ motif and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12495 Q6DN90 1182 1.4e-127 IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens GN=IQSEC1 PE=1 SV=1 PF01369//PF00612 Sec7 domain//IQ calmodulin-binding motif GO:0043087//GO:0032012 regulation of GTPase activity//regulation of ARF protein signal transduction GO:0005515//GO:0005086 protein binding//ARF guanyl-nucleotide exchange factor activity -- -- KOG0931 Predicted guanine nucleotide exchange factor, contains Sec7 domain Cluster-8309.27316 BP_3 11.00 0.39 1637 321475435 EFX86398.1 1032 2.3e-109 hypothetical protein DAPPUDRAFT_313180 [Daphnia pulex] -- -- -- -- -- K04520 APP amyloid beta A4 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04520 Q10651 767 5.0e-80 Beta-amyloid-like protein OS=Caenorhabditis elegans GN=apl-1 PE=1 SV=2 PF02177//PF12924//PF03938//PF03153 Amyloid A4 N-terminal heparin-binding//Copper-binding of amyloid precursor, CuBD//Outer membrane protein (OmpH-like)//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0008201//GO:0051082//GO:0046914 heparin binding//unfolded protein binding//transition metal ion binding GO:0005672 transcription factor TFIIA complex KOG3540 Beta amyloid precursor protein Cluster-8309.27318 BP_3 93.52 3.61 1541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27319 BP_3 309.69 6.51 2583 642933929 XP_008197571.1 903 3.3e-94 PREDICTED: nucleotide exchange factor SIL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUA7 500 7.3e-49 Nucleotide exchange factor SIL1 OS=Xenopus laevis GN=sil1 PE=2 SV=1 PF10389//PF11698//PF05479//PF12422 Bacteriophage coat protein B//V-ATPase subunit H//Photosystem I reaction centre subunit N (PSAN or PSI-N)//Condensin II non structural maintenance of chromosomes subunit GO:0015991//GO:0015979 ATP hydrolysis coupled proton transport//photosynthesis GO:0016820//GO:0005516 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//calmodulin binding GO:0000221//GO:0009522//GO:0005634//GO:0019028//GO:0042651 vacuolar proton-transporting V-type ATPase, V1 domain//photosystem I//nucleus//viral capsid//thylakoid membrane KOG2160 Armadillo/beta-catenin-like repeat-containing protein Cluster-8309.2732 BP_3 14.50 0.41 1993 642921890 XP_008192932.1 1687 3.1e-185 PREDICTED: cardioacceleratory peptide receptor 2 isoform X1 [Tribolium castaneum]>gi|296396897|gb|ADH10240.1| CCAP receptor 2 [Tribolium castaneum] -- -- -- -- -- K08376 NPSR1, GPR154 neuropeptide S receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08376 Q868T3 1070 4.5e-115 Cardioacceleratory peptide receptor OS=Drosophila melanogaster GN=CCAP-R PE=2 SV=3 PF00001//PF02118 7 transmembrane receptor (rhodopsin family)//Srg family chemoreceptor GO:0007186//GO:0007606//GO:0007187//GO:0007165 G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//signal transduction GO:0005000//GO:0004930//GO:0004888 vasopressin receptor activity//G-protein coupled receptor activity//transmembrane signaling receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.27320 BP_3 236.31 4.94 2599 642933929 XP_008197571.1 903 3.3e-94 PREDICTED: nucleotide exchange factor SIL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUA7 500 7.3e-49 Nucleotide exchange factor SIL1 OS=Xenopus laevis GN=sil1 PE=2 SV=1 PF12422//PF10389//PF11698//PF05479 Condensin II non structural maintenance of chromosomes subunit//Bacteriophage coat protein B//V-ATPase subunit H//Photosystem I reaction centre subunit N (PSAN or PSI-N) GO:0015979//GO:0015991 photosynthesis//ATP hydrolysis coupled proton transport GO:0005516//GO:0016820 calmodulin binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0019028//GO:0005634//GO:0042651//GO:0009522//GO:0000221 viral capsid//nucleus//thylakoid membrane//photosystem I//vacuolar proton-transporting V-type ATPase, V1 domain KOG2160 Armadillo/beta-catenin-like repeat-containing protein Cluster-8309.27323 BP_3 2200.38 51.03 2370 817084932 XP_012265132.1 661 3.5e-66 PREDICTED: protein SPT2 homolog [Athalia rosae] -- -- -- -- -- K15193 SPTY2D1, SPT2 protein SPT2 http://www.genome.jp/dbget-bin/www_bget?ko:K15193 Q8IMP6 227 3.0e-17 Protein SPT2 homolog OS=Drosophila melanogaster GN=CG5815 PE=1 SV=1 PF11648 C-terminal domain of RIG-I -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.27327 BP_3 7.05 0.33 1328 91093034 XP_970412.1 832 2.9e-86 PREDICTED: transmembrane protein 183 [Tribolium castaneum]>gi|270002700|gb|EEZ99147.1| hypothetical protein TcasGA2_TC012928 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IXX5 362 3.7e-33 Transmembrane protein 183A OS=Homo sapiens GN=TMEM183A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2733 BP_3 1.00 0.31 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27330 BP_3 502.03 18.26 1617 478257843 ENN77986.1 1014 2.8e-107 hypothetical protein YQE_05661, partial [Dendroctonus ponderosae] -- -- -- -- -- K00683 QPCT glutaminyl-peptide cyclotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00683 Q28120 632 2.2e-64 Glutaminyl-peptide cyclotransferase OS=Bos taurus GN=QPCT PE=1 SV=1 PF05450 Nicastrin GO:0016485 protein processing -- -- GO:0016021 integral component of membrane KOG3946 Glutaminyl cyclase Cluster-8309.27331 BP_3 822.33 23.87 1952 478257843 ENN77986.1 1016 2.0e-107 hypothetical protein YQE_05661, partial [Dendroctonus ponderosae] -- -- -- -- -- K00683 QPCT glutaminyl-peptide cyclotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00683 Q28120 632 2.7e-64 Glutaminyl-peptide cyclotransferase OS=Bos taurus GN=QPCT PE=1 SV=1 PF05450 Nicastrin GO:0016485 protein processing -- -- GO:0016021 integral component of membrane KOG3946 Glutaminyl cyclase Cluster-8309.27334 BP_3 40.06 0.45 4591 546678918 ERL89456.1 268 2.5e-20 hypothetical protein D910_06823 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 150 5.0e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF03470//PF13465//PF00096//PF03811//PF00643 XS zinc finger domain//Zinc-finger double domain//Zinc finger, C2H2 type//InsA N-terminal domain//B-box zinc finger GO:0006313//GO:0031047 transposition, DNA-mediated//gene silencing by RNA GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.27335 BP_3 345.81 3.00 5844 350414142 XP_003490218.1 2125 1.5e-235 PREDICTED: protein O-GlcNAcase isoform X3 [Bombus impatiens] 830022072 XM_012723671.1 44 9.23924e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 1092 3.7e-117 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 PF05418//PF09726//PF00736//PF06331//PF13673 Apovitellenin I (Apo-VLDL-II)//Transmembrane protein//EF-1 guanine nucleotide exchange domain//Transcription factor TFIIH complex subunit Tfb5//Acetyltransferase (GNAT) domain GO:0006355//GO:0006289//GO:0006414//GO:0006448//GO:0042967//GO:0006629 regulation of transcription, DNA-templated//nucleotide-excision repair//translational elongation//regulation of translational elongation//acyl-carrier-protein biosynthetic process//lipid metabolic process GO:0003746//GO:0008080//GO:0004857 translation elongation factor activity//N-acetyltransferase activity//enzyme inhibitor activity GO:0005853//GO:0005840//GO:0042627//GO:0000439//GO:0016021 eukaryotic translation elongation factor 1 complex//ribosome//chylomicron//core TFIIH complex//integral component of membrane KOG3698 Hyaluronoglucosaminidase Cluster-8309.27337 BP_3 281.01 7.42 2117 642920122 XP_008192215.1 371 1.3e-32 PREDICTED: microtubule-associated protein futsch isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00444 Ribosomal protein L36 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.27339 BP_3 659.00 19.64 1909 642924770 XP_008194433.1 1820 1.1e-200 PREDICTED: netrin receptor UNC5C isoform X1 [Tribolium castaneum] -- -- -- -- -- K07521 UNC5 netrin receptor unc-5 http://www.genome.jp/dbget-bin/www_bget?ko:K07521 Q8K1S4 563 2.7e-56 Netrin receptor UNC5A OS=Mus musculus GN=Unc5a PE=2 SV=1 PF01754//PF00531 A20-like zinc finger//Death domain GO:0007165 signal transduction GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding -- -- KOG1480 Netrin transmembrane receptor unc-5 Cluster-8309.2734 BP_3 7.43 0.67 829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27342 BP_3 31.63 0.55 3065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.27343 BP_3 759.46 9.30 4229 91079776 XP_967502.1 1323 1.1e-142 PREDICTED: coiled-coil domain-containing protein 50 [Tribolium castaneum]>gi|270004516|gb|EFA00964.1| hypothetical protein TcasGA2_TC003874 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IVM0 183 6.8e-12 Coiled-coil domain-containing protein 50 OS=Homo sapiens GN=CCDC50 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27345 BP_3 18.57 1.48 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27346 BP_3 17.00 2.04 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27348 BP_3 94.59 4.20 1378 642926052 XP_970129.2 648 6.5e-65 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41034 207 3.7e-15 Alpha-tocopherol transfer protein OS=Rattus norvegicus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2735 BP_3 1.00 0.85 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27352 BP_3 16.00 0.61 1558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27355 BP_3 2277.20 78.05 1698 91081049 XP_976170.1 580 6.1e-57 PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920368|ref|XP_008192316.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920370|ref|XP_008192317.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920372|ref|XP_008192318.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920374|ref|XP_008192319.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|270005238|gb|EFA01686.1| hypothetical protein TcasGA2_TC007261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27356 BP_3 39.63 1.41 1644 642930560 XP_008198137.1 285 9.6e-23 PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930562|ref|XP_008198139.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930564|ref|XP_008198145.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930566|ref|XP_008198152.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930568|ref|XP_008198158.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27359 BP_3 44.00 1.51 1699 568599608 AHE13799.1 269 7.1e-21 odorant binding protein [Lissorhoptrus oryzophilus] -- -- -- -- -- -- -- -- -- Q27017 158 2.2e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.2736 BP_3 3.37 0.32 795 795118357 XP_011831861.1 278 3.0e-22 PREDICTED: 40S ribosomal protein S26-like [Mandrillus leucophaeus] 768311752 CP010980.1 557 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 P21772 342 4.7e-31 40S ribosomal protein S26E OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-26 PE=3 SV=2 PF01283 Ribosomal protein S26e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1768 40s ribosomal protein S26 Cluster-8309.27360 BP_3 18.00 6.11 433 363498188 AEW24506.1 149 1.5e-07 Kazal-type protease inhibitor [Eriocheir sinensis] -- -- -- -- -- -- -- -- -- P0DKT1 145 1.8e-08 Turripeptide Pal9.2 OS=Polystira albida PE=2 SV=1 PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27361 BP_3 29.20 0.58 2729 91089737 XP_975124.1 1653 3.7e-181 PREDICTED: protein RFT1 homolog [Tribolium castaneum]>gi|270011306|gb|EFA07754.1| hypothetical protein TcasGA2_TC005308 [Tribolium castaneum] -- -- -- -- -- K06316 RFT1 oligosaccharide translocation protein RFT1 http://www.genome.jp/dbget-bin/www_bget?ko:K06316 Q9Y123 1075 1.6e-115 Protein RFT1 homolog OS=Drosophila melanogaster GN=CG3149 PE=2 SV=1 PF04506//PF01384 Rft protein//Phosphate transporter family GO:0006869//GO:0006817 lipid transport//phosphate ion transport GO:0005315//GO:0005319 inorganic phosphate transmembrane transporter activity//lipid transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.27363 BP_3 70.64 1.43 2671 478257449 ENN77605.1 1171 2.8e-125 hypothetical protein YQE_05900, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 553 5.4e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228 Stage II sporulation protein E (SpoIIE) -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.27364 BP_3 19.00 1.09 1130 641657806 XP_008180482.1 343 1.2e-29 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01322 Cytochrome C' GO:0006118 obsolete electron transport GO:0020037//GO:0005506//GO:0009055 heme binding//iron ion binding//electron carrier activity -- -- -- -- Cluster-8309.27365 BP_3 29.64 3.43 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27366 BP_3 82.77 2.97 1633 642939355 XP_008197126.1 746 3.3e-76 PREDICTED: N(6)-adenine-specific DNA methyltransferase 2 [Tribolium castaneum]>gi|270016449|gb|EFA12895.1| hypothetical protein TcasGA2_TC004409 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKT6 583 1.1e-58 Protein-lysine N-methyltransferase N6AMT2 OS=Gallus gallus GN=N6AMT2 PE=2 SV=1 PF10237//PF03602 Probable N6-adenine methyltransferase//Conserved hypothetical protein 95 GO:0031167//GO:0032259 rRNA methylation//methylation GO:0003676//GO:0008168 nucleic acid binding//methyltransferase activity -- -- KOG3350 Uncharacterized conserved protein Cluster-8309.27367 BP_3 424.90 11.15 2128 642939351 XP_008197109.1 761 7.9e-78 PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum]>gi|642939353|ref|XP_008197119.1| PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27368 BP_3 103.00 3.74 1619 642937257 XP_008198759.1 1340 4.4e-145 PREDICTED: serine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270001083|gb|EEZ97530.1| hypothetical protein TcasGA2_TC011377 [Tribolium castaneum] -- -- -- -- -- K01875 SARS, serS seryl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01875 Q9NP81 816 1.0e-85 Serine--tRNA ligase, mitochondrial OS=Homo sapiens GN=SARS2 PE=1 SV=1 PF00587//PF03260 tRNA synthetase class II core domain (G, H, P, S and T)//Lepidopteran low molecular weight (30 kD) lipoprotein GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//ATP binding//nucleotide binding GO:0005576 extracellular region KOG2509 Seryl-tRNA synthetase Cluster-8309.27369 BP_3 36.66 0.69 2859 332374922 AEE62602.1 644 3.9e-64 unknown [Dendroctonus ponderosae]>gi|478263079|gb|ENN81479.1| hypothetical protein YQE_02171, partial [Dendroctonus ponderosae]>gi|546682121|gb|ERL92102.1| hypothetical protein D910_09423 [Dendroctonus ponderosae] -- -- -- -- -- K09562 HSPBP1 hsp70-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K09562 Q6IMX7 163 9.6e-10 Hsp70-binding protein 1 OS=Rattus norvegicus GN=Hspbp1 PE=2 SV=1 PF02686//PF00514 Glu-tRNAGln amidotransferase C subunit//Armadillo/beta-catenin-like repeat GO:0006450 regulation of translational fidelity GO:0005515 protein binding -- -- KOG2160 Armadillo/beta-catenin-like repeat-containing protein Cluster-8309.2737 BP_3 1504.63 82.39 1172 815769669 XP_012234959.1 698 8.8e-71 PREDICTED: uncharacterized protein LOC105679478 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05408 Foot-and-mouth virus L-proteinase GO:0019082//GO:0006508//GO:0016032 viral protein processing//proteolysis//viral process GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.27370 BP_3 1773.00 55.02 1845 91085765 XP_974179.1 1335 1.9e-144 PREDICTED: F-actin-capping protein subunit alpha [Tribolium castaneum]>gi|270009998|gb|EFA06446.1| hypothetical protein TcasGA2_TC009328 [Tribolium castaneum] -- -- -- -- -- K10364 CAPZA capping protein (actin filament) muscle Z-line, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K10364 Q9W2N0 1129 6.0e-122 F-actin-capping protein subunit alpha OS=Drosophila melanogaster GN=cpa PE=2 SV=1 PF01267 F-actin capping protein alpha subunit GO:0051016//GO:0030036 barbed-end actin filament capping//actin cytoskeleton organization GO:0003779 actin binding GO:0008290 F-actin capping protein complex KOG0836 F-actin capping protein, alpha subunit Cluster-8309.27371 BP_3 50.00 5.20 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27372 BP_3 157.16 1.48 5401 642935917 XP_008198228.1 1808 7.9e-199 PREDICTED: dual specificity protein phosphatase Mpk3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9VVW5 860 2.7e-90 Dual specificity protein phosphatase Mpk3 OS=Drosophila melanogaster GN=Mkp3 PE=1 SV=2 PF04179//PF00782//PF05706//PF00102 Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0019988//GO:0006570//GO:0006470 charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0004721//GO:0008138//GO:0043399 protein tyrosine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity -- -- KOG1717 Dual specificity phosphatase Cluster-8309.27374 BP_3 1340.24 9.12 7373 642929628 XP_008195910.1 1232 6.6e-132 PREDICTED: integrin alpha-X-like [Tribolium castaneum] -- -- -- -- -- K06585 ITGA9 integrin alpha 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06585 O44386 633 7.8e-64 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.27376 BP_3 242.77 6.25 2164 642911000 XP_008193502.1 296 6.7e-24 PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum]>gi|642911002|ref|XP_008193503.1| PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05019//PF00191//PF16113 Coenzyme Q (ubiquinone) biosynthesis protein Coq4//Annexin//Enoyl-CoA hydratase/isomerase GO:0006744 ubiquinone biosynthetic process GO:0005544//GO:0016836//GO:0005509 calcium-dependent phospholipid binding//hydro-lyase activity//calcium ion binding -- -- -- -- Cluster-8309.27379 BP_3 186.84 65.74 428 817055776 XP_012268719.1 727 1.4e-74 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X2 [Athalia rosae] 665820405 XM_008560879.1 158 2.6691e-75 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 580 6.3e-59 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.2738 BP_3 152.00 7.39 1283 642910810 XP_008193419.1 1041 1.6e-110 PREDICTED: uncharacterized protein LOC103313033 [Tribolium castaneum]>gi|270014982|gb|EFA11430.1| hypothetical protein TcasGA2_TC013608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01686 Adenovirus penton base protein -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.27380 BP_3 10.28 0.67 1026 746851175 XP_011056100.1 720 2.2e-73 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X4 [Acromyrmex echinatior] 268574973 XM_002642420.1 87 1.97163e-35 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 601 5.6e-61 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01517//PF16326//PF04111//PF01496//PF00769 Hepatitis delta virus delta antigen//ABC transporter C-terminal domain//Autophagy protein Apg6//V-type ATPase 116kDa subunit family//Ezrin/radixin/moesin family GO:0015992//GO:0015991//GO:0006914 proton transport//ATP hydrolysis coupled proton transport//autophagy GO:0015078//GO:0003677//GO:0003723//GO:0008092 hydrogen ion transmembrane transporter activity//DNA binding//RNA binding//cytoskeletal protein binding GO:0005737//GO:0033179//GO:0042025//GO:0019898 cytoplasm//proton-transporting V-type ATPase, V0 domain//host cell nucleus//extrinsic component of membrane KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27381 BP_3 2078.92 65.14 1830 546681043 ERL91208.1 2252 8.7e-251 hypothetical protein D910_08546 [Dendroctonus ponderosae] 820861306 XM_012491990.1 156 1.56803e-73 PREDICTED: Apis florea V-type proton ATPase 116 kDa subunit a isoform 1-like (LOC100868664), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q29466 1515 1.0e-166 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Bos taurus GN=ATP6V0A1 PE=2 SV=1 PF01496 V-type ATPase 116kDa subunit family GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27382 BP_3 102.44 1.23 4309 642912101 XP_008200805.1 862 3.1e-89 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [Tribolium castaneum] 665820405 XM_008560879.1 190 4.69234e-92 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 604 1.1e-60 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27383 BP_3 8.24 1.79 513 768421708 XP_011551676.1 702 1.3e-71 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Plutella xylostella] 665820405 XM_008560879.1 157 1.16376e-74 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 561 1.2e-56 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27384 BP_3 766.99 7.26 5382 512921142 XP_004929807.1 2290 1.0e-254 PREDICTED: bestrophin-4 isoform X2 [Bombyx mori] 644995962 XM_001603356.3 234 2.03808e-116 PREDICTED: Nasonia vitripennis putative lysozyme-like protein (LOC100119673), transcript variant X1, mRNA -- -- -- -- Q6H1V1 898 1.1e-94 Bestrophin-3 OS=Mus musculus GN=Best3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.27385 BP_3 404.95 22.43 1162 749733307 XP_011145187.1 1537 4.5e-168 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X3 [Harpegnathos saltator] 665820405 XM_008560879.1 345 8.48578e-179 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 1199 2.9e-130 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF04111//PF03938//PF01517//PF01496 Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Hepatitis delta virus delta antigen//V-type ATPase 116kDa subunit family GO:0006914//GO:0015991//GO:0015992 autophagy//ATP hydrolysis coupled proton transport//proton transport GO:0003723//GO:0051082//GO:0015078 RNA binding//unfolded protein binding//hydrogen ion transmembrane transporter activity GO:0042025//GO:0033179 host cell nucleus//proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27387 BP_3 26.22 9.23 428 332374848 AEE62565.1 739 5.6e-76 unknown [Dendroctonus ponderosae] 665820405 XM_008560879.1 157 9.59979e-75 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 561 1.0e-56 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27390 BP_3 941.39 27.46 1944 91077186 XP_972614.1 1315 4.2e-142 PREDICTED: cyclin-K [Tribolium castaneum]>gi|270001704|gb|EEZ98151.1| hypothetical protein TcasGA2_TC000577 [Tribolium castaneum] 766919740 XM_011506006.1 277 9.09003e-141 PREDICTED: Ceratosolen solmsi marchali cyclin-K (LOC105367338), transcript variant X2, mRNA -- -- -- -- O75909 990 8.3e-106 Cyclin-K OS=Homo sapiens GN=CCNK PE=1 SV=2 PF02984 Cyclin, C-terminal domain GO:0000079//GO:0006355 regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0005634 nucleus KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.27394 BP_3 8.04 0.37 1353 91077326 XP_974776.1 962 2.5e-101 PREDICTED: pyrroline-5-carboxylate reductase 3 [Tribolium castaneum]>gi|270001668|gb|EEZ98115.1| hypothetical protein TcasGA2_TC000533 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q5SPD7 558 7.1e-56 Pyrroline-5-carboxylate reductase 3 OS=Danio rerio GN=pycrl PE=2 SV=1 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0019521//GO:0006561//GO:0006098//GO:0006525 oxidation-reduction process//D-gluconate metabolic process//proline biosynthetic process//pentose-phosphate shunt//arginine metabolic process GO:0000166//GO:0004616//GO:0004735 nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity//pyrroline-5-carboxylate reductase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.27395 BP_3 400.87 11.39 1988 91091868 XP_969098.1 1588 9.4e-174 PREDICTED: 26S proteasome non-ATPase regulatory subunit 5 [Tribolium castaneum]>gi|270001117|gb|EEZ97564.1| hypothetical protein TcasGA2_TC011419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16401 742 4.8e-77 26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens GN=PSMD5 PE=1 SV=3 PF02985//PF10508//PF11698//PF00514 HEAT repeat//Proteasome non-ATPase 26S subunit//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0015991//GO:0043248 ATP hydrolysis coupled proton transport//proteasome assembly GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.27396 BP_3 41.51 0.34 6095 189240296 XP_973610.2 2420 9.6e-270 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 P55156 727 8.2e-75 Microsomal triglyceride transfer protein large subunit (Fragment) OS=Bos taurus GN=MTTP PE=1 SV=1 PF01347//PF00019//PF00397 Lipoprotein amino terminal region//Transforming growth factor beta like domain//WW domain GO:0008283//GO:0006869//GO:0040007//GO:0007165 cell proliferation//lipid transport//growth//signal transduction GO:0005515//GO:0005319//GO:0008083 protein binding//lipid transporter activity//growth factor activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.27398 BP_3 69.05 0.61 5792 642918795 XP_008191588.1 293 4.0e-23 PREDICTED: uncharacterized protein LOC103312529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27399 BP_3 36.19 0.81 2438 642936610 XP_008198505.1 266 2.3e-20 PREDICTED: uncharacterized protein LOC661523 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2740 BP_3 837.77 22.39 2095 642917922 XP_008200616.1 1570 1.2e-171 PREDICTED: probable cytochrome P450 303a1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q9V399 1053 4.4e-113 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.27400 BP_3 97.21 1.02 4906 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27401 BP_3 713.00 54.10 927 91077738 XP_975157.1 534 7.2e-52 PREDICTED: prefoldin subunit 2 [Tribolium castaneum]>gi|270001520|gb|EEZ97967.1| hypothetical protein TcasGA2_TC000359 [Tribolium castaneum] -- -- -- -- -- K09549 PFDN2 prefoldin subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09549 A1A4P5 349 8.4e-32 Prefoldin subunit 2 OS=Bos taurus GN=PFDN2 PE=2 SV=1 PF01920 Prefoldin subunit GO:0006457 protein folding GO:0051082 unfolded protein binding GO:0016272 prefoldin complex KOG4098 Molecular chaperone Prefoldin, subunit 2 Cluster-8309.27404 BP_3 947.57 68.24 961 642939160 XP_969591.2 809 9.7e-84 PREDICTED: protein D3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 624 1.1e-63 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.27405 BP_3 1172.88 5.85 9956 478250015 ENN70521.1 4003 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 573901209 XM_006638269.1 121 2.47672e-53 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2864 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF06414//PF00063//PF00612//PF06017//PF00437 Zeta toxin//Myosin head (motor domain)//IQ calmodulin-binding motif//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0005524//GO:0003774//GO:0016301//GO:0005515 ATP binding//motor activity//kinase activity//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.27406 BP_3 779.26 3.93 9845 478250015 ENN70521.1 4003 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 573901209 XM_006638269.1 121 2.449e-53 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2864 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF06414//PF00063//PF00612//PF06017//PF00437 Zeta toxin//Myosin head (motor domain)//IQ calmodulin-binding motif//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0005515//GO:0016301//GO:0003774//GO:0005524 protein binding//kinase activity//motor activity//ATP binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.27409 BP_3 2885.44 17.84 8086 642936743 XP_008198562.1 5262 0.0e+00 PREDICTED: neurexin-4 isoform X1 [Tribolium castaneum] 662206951 XM_008478733.1 135 3.31584e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 4430 0.0e+00 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF03079//PF01106//PF00008//PF01648 ARD/ARD' family//NifU-like domain//EGF-like domain//4'-phosphopantetheinyl transferase superfamily GO:0055114//GO:0015940//GO:0016226 oxidation-reduction process//pantothenate biosynthetic process//iron-sulfur cluster assembly GO:0005506//GO:0000287//GO:0051536//GO:0008897//GO:0005515//GO:0010309 iron ion binding//magnesium ion binding//iron-sulfur cluster binding//holo-[acyl-carrier-protein] synthase activity//protein binding//acireductone dioxygenase [iron(II)-requiring] activity -- -- -- -- Cluster-8309.27410 BP_3 22.27 0.33 3567 642928840 XP_008195584.1 1446 4.9e-157 PREDICTED: dystrophin, isoform E-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDW6 528 5.7e-52 Dystrophin, isoforms A/C/F/G/H OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF00397//PF00569 WW domain//Zinc finger, ZZ type -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.27411 BP_3 313.89 3.78 4299 642921365 XP_972788.2 3505 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 2.24054e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1306 4.2e-142 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF12678//PF12861//PF00787//PF00097//PF13639 RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//PX domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0035091//GO:0004842//GO:0008270 metal ion binding//protein binding//phosphatidylinositol binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.27413 BP_3 21.58 1.36 1059 270001667 EEZ98114.1 763 2.3e-78 hypothetical protein TcasGA2_TC000532 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15757 Amelotin GO:0070175//GO:0042475 positive regulation of enamel mineralization//odontogenesis of dentin-containing tooth -- -- -- -- -- -- Cluster-8309.27416 BP_3 217.67 6.90 1813 642938101 XP_008199656.1 197 1.7e-12 PREDICTED: THAP domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.27417 BP_3 18.30 0.41 2419 100811805 BAE94685.1 2512 8.2e-281 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 754 2.4e-78 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.27418 BP_3 69.00 0.78 4546 805752828 XP_012154051.1 3786 0.0e+00 PREDICTED: alpha-actinin, sarcomeric isoform X2 [Megachile rotundata] 442614869 NM_001201604.2 882 0 Drosophila melanogaster alpha actinin (Actn), transcript variant I, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q7PKQ5 3704 0.0e+00 Alpha-actinin, sarcomeric OS=Anopheles gambiae GN=Actn PE=3 SV=2 PF00307//PF07934//PF13499//PF00296//PF00036//PF13405//PF00435 Calponin homology (CH) domain//8-oxoguanine DNA glycosylase, N-terminal domain//EF-hand domain pair//Luciferase-like monooxygenase//EF hand//EF-hand domain//Spectrin repeat GO:0006308//GO:0006289//GO:0055114//GO:0006285//GO:0006281 DNA catabolic process//nucleotide-excision repair//oxidation-reduction process//base-excision repair, AP site formation//DNA repair GO:0003684//GO:0008534//GO:0005509//GO:0005515//GO:0016705 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//calcium ion binding//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.27422 BP_3 40.00 5.40 649 459353537 AGG55290.1 798 1.2e-82 ribosomal protein L18 [Litopenaeus vannamei] 612061316 XM_007506695.1 40 1.63812e-09 PREDICTED: Monodelphis domestica ribosomal protein L18 (RPL18), mRNA K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q4GXG7 731 3.0e-76 60S ribosomal protein L18 OS=Timarcha balearica GN=RpL18 PE=2 SV=1 PF05039 Agouti protein GO:0009755 hormone-mediated signaling pathway -- -- GO:0005576 extracellular region KOG1714 60s ribosomal protein L18 Cluster-8309.27424 BP_3 21.00 0.41 2746 499037689 XP_004569491.1 613 1.5e-60 PREDICTED: zinc finger protein 883-like [Maylandia zebra] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6P5C7 548 2.1e-54 Zinc finger protein 728 OS=Mus musculus GN=Znf728 PE=2 SV=1 PF16622//PF05191//PF00412//PF02892//PF13912//PF13465//PF06467//PF00628//PF07649//PF01155//PF02069//PF00096 zinc-finger C2H2-type//Adenylate kinase, active site lid//LIM domain//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//MYM-type Zinc finger with FCS sequence motif//PHD-finger//C1-like domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Prokaryotic metallothionein//Zinc finger, C2H2 type GO:0055114//GO:0046034//GO:0006144//GO:0006464 oxidation-reduction process//ATP metabolic process//purine nucleobase metabolic process//cellular protein modification process GO:0004017//GO:0047134//GO:0046872//GO:0008270//GO:0016151//GO:0005515//GO:0003677 adenylate kinase activity//protein-disulfide reductase activity//metal ion binding//zinc ion binding//nickel cation binding//protein binding//DNA binding -- -- -- -- Cluster-8309.27425 BP_3 176.39 10.72 1085 91093429 XP_968933.1 554 4.1e-54 PREDICTED: uncharacterized protein LOC657376 [Tribolium castaneum]>gi|270015461|gb|EFA11909.1| hypothetical protein TcasGA2_TC004066 [Tribolium castaneum] -- -- -- -- -- K18157 TMEM126A transmembrane protein 126A http://www.genome.jp/dbget-bin/www_bget?ko:K18157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27426 BP_3 148.24 1.41 5363 546678750 ERL89302.1 1357 1.5e-146 hypothetical protein D910_06674 [Dendroctonus ponderosae] -- -- -- -- -- K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 -- -- -- -- PF12106//PF05656 Colicin C terminal ribonuclease domain//Protein of unknown function (DUF805) GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.2743 BP_3 301.25 4.66 3409 546686178 ERL95558.1 373 1.2e-32 hypothetical protein D910_12819 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27431 BP_3 6.00 1.03 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27435 BP_3 1653.55 58.21 1661 642930353 XP_008196361.1 1876 3.1e-207 PREDICTED: protein 4.1 homolog isoform X2 [Tribolium castaneum] 642930352 XM_008198139.1 476 0 PREDICTED: Tribolium castaneum protein 4.1 homolog (LOC662229), transcript variant X3, mRNA K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1380 4.2e-151 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27437 BP_3 38.37 1.09 1996 478255350 ENN75576.1 697 2.0e-70 hypothetical protein YQE_07919, partial [Dendroctonus ponderosae] -- -- -- -- -- K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q9VSD7 509 5.1e-50 Lariat debranching enzyme OS=Drosophila melanogaster GN=ldbr PE=1 SV=1 PF05011 Lariat debranching enzyme, C-terminal domain GO:0006397 mRNA processing GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2863 RNA lariat debranching enzyme Cluster-8309.27438 BP_3 1731.96 13.44 6501 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.2744 BP_3 20.00 1.73 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02891 MIZ/SP-RING zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.27440 BP_3 25.72 0.74 1977 642912940 XP_008201316.1 796 6.4e-82 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 531 1.4e-52 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27442 BP_3 424.58 4.18 5190 642920483 XP_008192370.1 2537 2.2e-283 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86W92 885 3.3e-93 Liprin-beta-1 OS=Homo sapiens GN=PPFIBP1 PE=1 SV=2 PF02601//PF01496//PF07647//PF00536//PF02198//PF01763 Exonuclease VII, large subunit//V-type ATPase 116kDa subunit family//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain//Herpesvirus UL6 like GO:0006308//GO:0015992//GO:0006323//GO:0015991 DNA catabolic process//proton transport//DNA packaging//ATP hydrolysis coupled proton transport GO:0015078//GO:0043565//GO:0005515//GO:0008855 hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//protein binding//exodeoxyribonuclease VII activity GO:0009318//GO:0033179//GO:0005634 exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain//nucleus KOG0249 LAR-interacting protein and related proteins Cluster-8309.27444 BP_3 22.07 0.54 2279 189237356 XP_969548.2 835 2.2e-86 PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|642923199|ref|XP_008193652.1| PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|270007091|gb|EFA03539.1| hypothetical protein TcasGA2_TC013542 [Tribolium castaneum] 734601940 XM_010729598.1 103 5.68656e-44 PREDICTED: Larimichthys crocea transmembrane 9 superfamily member 2-like (LOC104917993), transcript variant X2, mRNA K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q99805 705 1.1e-72 Transmembrane 9 superfamily member 2 OS=Homo sapiens GN=TM9SF2 PE=1 SV=1 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.27449 BP_3 58.72 1.68 1977 91094295 XP_971662.1 1667 6.4e-183 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 1449 5.0e-159 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF00441//PF02770//PF02771 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0006118//GO:0008152 oxidation-reduction process//obsolete electron transport//metabolic process GO:0016627//GO:0003995//GO:0050660 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.27451 BP_3 2.75 18.00 255 270014888 EFA11336.1 218 8.6e-16 hypothetical protein TcasGA2_TC010876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62951 127 1.3e-06 Dihydropyrimidinase-related protein 4 (Fragment) OS=Rattus norvegicus GN=Dpysl4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2584 Dihydroorotase and related enzymes Cluster-8309.27452 BP_3 40.00 1.08 2069 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27455 BP_3 56.32 0.64 4504 780649216 XP_011689959.1 1096 2.4e-116 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00589 Phage integrase family GO:0015074//GO:0006310 DNA integration//DNA recombination GO:0003677 DNA binding -- -- -- -- Cluster-8309.2746 BP_3 4.00 1.64 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27460 BP_3 3.00 0.46 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27462 BP_3 286.00 3.48 4254 821489447 XP_012407072.1 842 6.4e-87 PREDICTED: zinc finger protein 420-like [Sarcophilus harrisii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZN57 809 1.8e-84 Zinc finger protein 2 homolog OS=Homo sapiens GN=ZFP2 PE=1 SV=1 PF00076//PF13465//PF16622//PF00641//PF13912//PF00096//PF07776//PF01585 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc-finger double domain//zinc-finger C2H2-type//Zn-finger in Ran binding protein and others//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//G-patch domain -- -- GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.27466 BP_3 314.17 4.28 3828 91082137 XP_966595.1 1646 3.4e-180 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 178 1.95114e-85 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1351 2.3e-147 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.27469 BP_3 619.23 6.49 4888 270003267 EEZ99714.1 1734 2.7e-190 hypothetical protein TcasGA2_TC002475 [Tribolium castaneum] 642918335 XM_008198635.1 172 5.40409e-82 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tricorner (LOC655192), mRNA K08790 STK38, NDR serine/threonine kinase 38 http://www.genome.jp/dbget-bin/www_bget?ko:K08790 Q2LZZ7 1573 5.2e-173 Serine/threonine-protein kinase tricorner OS=Drosophila pseudoobscura pseudoobscura GN=trc PE=3 SV=1 PF07714//PF04096//PF00433//PF06293//PF00069//PF04998 Protein tyrosine kinase//Nucleoporin autopeptidase//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//RNA polymerase Rpb1, domain 5 GO:0006206//GO:0006351//GO:0016310//GO:0006144//GO:0006810//GO:0006468//GO:0009069 pyrimidine nucleobase metabolic process//transcription, DNA-templated//phosphorylation//purine nucleobase metabolic process//transport//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004672//GO:0003677//GO:0004674//GO:0003899//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//DNA binding//protein serine/threonine kinase activity//DNA-directed RNA polymerase activity//ATP binding GO:0016020//GO:0005643//GO:0005730 membrane//nuclear pore//nucleolus KOG0605 NDR and related serine/threonine kinases Cluster-8309.2747 BP_3 3.00 0.39 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27470 BP_3 105.23 3.11 1922 236468408 NP_001153625.1 896 1.6e-93 spaetzle 3 [Tribolium castaneum] 817194790 XM_012417488.1 155 5.92868e-73 PREDICTED: Orussus abietinus uncharacterized LOC105695690 (LOC105695690), mRNA -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.27473 BP_3 38.82 0.39 5127 91089951 XP_973444.1 1186 1.0e-126 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013551|gb|EFA09999.1| hypothetical protein TcasGA2_TC012169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q55EH8 440 1.3e-41 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF01061//PF13304//PF00005 ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter -- -- GO:0016887//GO:0005524//GO:0017111 ATPase activity//ATP binding//nucleoside-triphosphatase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.27475 BP_3 44.00 1.30 1917 91084359 XP_973264.1 1545 8.7e-169 PREDICTED: facilitated trehalose transporter Tret1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY3 534 6.1e-53 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF02200 Sugar (and other) transporter//Major Facilitator Superfamily//STE like transcription factor GO:0055085//GO:0006355 transmembrane transport//regulation of transcription, DNA-templated GO:0022857//GO:0003700 transmembrane transporter activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0016021//GO:0005667 nucleus//integral component of membrane//transcription factor complex KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.27477 BP_3 11.40 0.33 1979 642922261 XP_008193083.1 175 6.6e-10 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27478 BP_3 134.26 3.42 2185 642915291 XP_008190557.1 1450 1.0e-157 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 678 1.4e-69 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.27479 BP_3 112.24 3.95 1663 478255105 ENN75335.1 993 7.7e-105 hypothetical protein YQE_08111, partial [Dendroctonus ponderosae]>gi|546680135|gb|ERL90476.1| hypothetical protein D910_07825 [Dendroctonus ponderosae] 766923225 XM_011507925.1 101 5.33672e-43 PREDICTED: Ceratosolen solmsi marchali uracil phosphoribosyltransferase homolog (LOC105368798), transcript variant X2, mRNA K00761 upp, UPRT uracil phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00761 Q5ZIJ8 706 6.1e-73 Uracil phosphoribosyltransferase homolog OS=Gallus gallus GN=UPRT PE=2 SV=1 PF00156 Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process -- -- -- -- KOG1017 Predicted uracil phosphoribosyltransferase Cluster-8309.27480 BP_3 669.75 6.59 5189 91084319 XP_972276.1 1874 1.7e-206 PREDICTED: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum]>gi|270008807|gb|EFA05255.1| hypothetical protein TcasGA2_TC015407 [Tribolium castaneum] -- -- -- -- -- K03848 ALG6 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03848 Q802T2 1115 7.1e-120 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Gallus gallus GN=ALG6 PE=2 SV=1 PF00288//PF03155//PF04055 GHMP kinases N terminal domain//ALG6, ALG8 glycosyltransferase family//Radical SAM superfamily -- -- GO:0016758//GO:0005524//GO:0003824//GO:0051536 transferase activity, transferring hexosyl groups//ATP binding//catalytic activity//iron-sulfur cluster binding GO:0005789 endoplasmic reticulum membrane KOG2575 Glucosyltransferase - Alg6p Cluster-8309.27481 BP_3 482.71 8.47 3038 189238741 XP_972079.2 2951 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927110|ref|XP_008195141.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927112|ref|XP_008195142.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927115|ref|XP_008195143.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum] 699256288 XM_009863644.1 39 2.87412e-08 PREDICTED: Ciona intestinalis ubiquitin carboxyl-terminal hydrolase 20-like (LOC100184024), mRNA K11848 USP20_33 ubiquitin carboxyl-terminal hydrolase 20/33 http://www.genome.jp/dbget-bin/www_bget?ko:K11848 A0JM59 1233 8.6e-134 Ubiquitin carboxyl-terminal hydrolase 20 OS=Xenopus tropicalis GN=usp20 PE=2 SV=1 PF00443//PF17001//PF06337//PF02148 Ubiquitin carboxyl-terminal hydrolase//Type III secretion basal body protein I, YscI, HrpB, PscI//DUSP domain//Zn-finger in ubiquitin-hydrolases and other protein GO:0009306//GO:0016579//GO:0006508 protein secretion//protein deubiquitination//proteolysis GO:0036459//GO:0008270//GO:0004843 ubiquitinyl hydrolase activity//zinc ion binding//ubiquitin-specific protease activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.27482 BP_3 26.98 1.11 1467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27486 BP_3 14.00 0.38 2066 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27487 BP_3 167.12 1.33 6354 642912779 XP_008201247.1 4214 0.0e+00 PREDICTED: chaoptin isoform X1 [Tribolium castaneum] 759065584 XM_011343927.1 47 2.1592e-12 PREDICTED: Cerapachys biroi homeobox protein Hox-B1a-like (LOC105282160), mRNA -- -- -- -- P12024 2995 0.0e+00 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF13855//PF00046 Leucine Rich Repeat//Leucine rich repeat//Homeobox domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.27489 BP_3 20.13 0.35 3073 780626002 XP_011684334.1 531 5.3e-51 PREDICTED: uncharacterized protein LOC105447823 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27490 BP_3 122.76 2.50 2654 123227460 CAM27169.1 868 3.9e-90 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] 741950160 XM_010812049.1 36 1.16696e-06 PREDICTED: Bos taurus zinc finger and SCAN domain-containing protein 5B-like (LOC790324), partial mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8N8J6 853 8.7e-90 Zinc finger protein 615 OS=Homo sapiens GN=ZNF615 PE=2 SV=2 PF07776//PF13912//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.27491 BP_3 332.00 6.55 2735 642916469 XP_008191039.1 2873 0.0e+00 PREDICTED: anaphase-promoting complex subunit 2 [Tribolium castaneum]>gi|270003625|gb|EFA00073.1| hypothetical protein TcasGA2_TC002887 [Tribolium castaneum] -- -- -- -- -- K03349 APC2 anaphase-promoting complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03349 Q9UJX6 1367 2.2e-149 Anaphase-promoting complex subunit 2 OS=Homo sapiens GN=ANAPC2 PE=1 SV=1 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2165 Anaphase-promoting complex (APC), subunit 2 Cluster-8309.27493 BP_3 84.45 4.54 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646 F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27496 BP_3 108.61 2.67 2252 332372732 AEE61508.1 1086 1.7e-115 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 735 3.6e-76 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191//PF08294//PF00802 Annexin//TIM21//Pneumovirus attachment glycoprotein G GO:0030150 protein import into mitochondrial matrix GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding GO:0055036//GO:0005744 virion membrane//mitochondrial inner membrane presequence translocase complex KOG0819 Annexin Cluster-8309.27497 BP_3 12.27 0.63 1230 91078976 XP_974454.1 397 7.4e-36 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2750 BP_3 21.00 0.79 1572 642914257 XP_008201609.1 2342 2.7e-261 PREDICTED: transmembrane and TPR repeat-containing protein 1-like [Tribolium castaneum]>gi|270001551|gb|EEZ97998.1| hypothetical protein TcasGA2_TC000396 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UV71 790 1.0e-82 Transmembrane and TPR repeat-containing protein 1 OS=Mus musculus GN=Tmtc1 PE=2 SV=2 PF13414//PF13174//PF13176//PF00515//PF13374//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1124 FOG: TPR repeat Cluster-8309.27500 BP_3 130.63 1.08 6125 91089043 XP_969794.1 2493 3.3e-278 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] 657579724 XM_008295570.1 270 2.25656e-136 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 1895 3.0e-210 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.27501 BP_3 541.92 7.46 3791 91082211 XP_972371.1 1201 1.3e-128 PREDICTED: caspase-8 [Tribolium castaneum]>gi|270008200|gb|EFA04648.1| death related ced-3/Nedd2-like protein [Tribolium castaneum] -- -- -- -- -- K15275 SLC35B1 solute carrier family 35 (UDP-galactose transporter), member B1 http://www.genome.jp/dbget-bin/www_bget?ko:K15275 Q9VDD7 776 1.1e-80 Solute carrier family 35 member B1 homolog OS=Drosophila melanogaster GN=meigo PE=2 SV=1 PF08449//PF00656//PF00892 UAA transporter family//Caspase domain//EamA-like transporter family GO:0055085//GO:0006508 transmembrane transport//proteolysis GO:0004197 cysteine-type endopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1581 UDP-galactose transporter related protein Cluster-8309.27502 BP_3 551.00 19.40 1661 264667473 ACY71322.1 543 1.2e-52 non-histone chromosome protein 2 [Chrysomela tremula] 689542333 LL999135.1 61 9.17526e-21 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_contig0000068 K12845 SNU13, NHP2L U4/U6 small nuclear ribonucleoprotein SNU13 http://www.genome.jp/dbget-bin/www_bget?ko:K12845 Q5XH16 475 3.7e-46 NHP2-like protein 1 OS=Xenopus laevis GN=nhp2l1 PE=2 SV=1 PF07180 Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- -- -- KOG3387 60S ribosomal protein 15.5kD/SNU13, NHP2/L7A family (includes ribonuclease P subunit p38), involved in splicing Cluster-8309.27503 BP_3 3.00 0.46 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02976 DNA mismatch repair enzyme MutH -- -- GO:0003677//GO:0004519 DNA binding//endonuclease activity -- -- -- -- Cluster-8309.27507 BP_3 98.87 1.84 2877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00672//PF08783 HAMP domain//DWNN domain GO:0007165 signal transduction GO:0004871//GO:0008270 signal transducer activity//zinc ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.27508 BP_3 17.13 0.38 2459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08783//PF00672 DWNN domain//HAMP domain GO:0007165 signal transduction GO:0008270//GO:0004871 zinc ion binding//signal transducer activity GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.27509 BP_3 657.35 14.70 2447 91080725 XP_975392.1 2452 7.5e-274 PREDICTED: arginine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270005463|gb|EFA01911.1| hypothetical protein TcasGA2_TC007521 [Tribolium castaneum] 306980173 CP002198.1 65 8.13369e-23 Cyanothece sp. PCC 7822, complete genome K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 Q5ZM11 1964 1.2e-218 Arginine--tRNA ligase, cytoplasmic OS=Gallus gallus GN=RARS PE=2 SV=1 PF05746//PF00133//PF09334//PF03485//PF00750//PF07062 DALR anticodon binding domain//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Arginyl tRNA synthetase N terminal domain//tRNA synthetases class I (R)//Clc-like GO:0006525//GO:0006560//GO:0006420//GO:0006418 arginine metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0005524//GO:0004814//GO:0000166//GO:0004812 ATP binding//arginine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG4426 Arginyl-tRNA synthetase Cluster-8309.2751 BP_3 6.00 0.47 908 642914257 XP_008201609.1 192 3.2e-12 PREDICTED: transmembrane and TPR repeat-containing protein 1-like [Tribolium castaneum]>gi|270001551|gb|EEZ97998.1| hypothetical protein TcasGA2_TC000396 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27513 BP_3 692.37 8.69 4130 91086685 XP_969056.1 2107 1.3e-233 PREDICTED: ubiquitin carboxyl-terminal hydrolase 14 [Tribolium castaneum]>gi|270009745|gb|EFA06193.1| hypothetical protein TcasGA2_TC009042 [Tribolium castaneum] 871234385 XM_013082848.1 61 2.30945e-20 PREDICTED: Aplysia californica ubiquitin carboxyl-terminal hydrolase 14-like (LOC101847343), mRNA K11843 USP14, UBP6 ubiquitin carboxyl-terminal hydrolase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11843 Q9JMA1 1512 5.2e-166 Ubiquitin carboxyl-terminal hydrolase 14 OS=Mus musculus GN=Usp14 PE=1 SV=3 PF00240//PF15499//PF00443 Ubiquitin family//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0006511//GO:0006508 protein deubiquitination//ubiquitin-dependent protein catabolic process//proteolysis GO:0008234//GO:0004221//GO:0005515//GO:0036459//GO:0032183//GO:0070140 cysteine-type peptidase activity//obsolete ubiquitin thiolesterase activity//protein binding//ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity -- -- KOG1872 Ubiquitin-specific protease Cluster-8309.27514 BP_3 68.10 1.84 2073 189235221 XP_967494.2 169 3.4e-09 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27516 BP_3 7.19 0.48 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27518 BP_3 1399.11 10.63 6634 642919747 XP_008192048.1 4344 0.0e+00 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 1423 1.7e-155 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3321 Mitochondrial ribosomal protein S10 Cluster-8309.2752 BP_3 12.33 0.78 1053 642914257 XP_008201609.1 655 7.6e-66 PREDICTED: transmembrane and TPR repeat-containing protein 1-like [Tribolium castaneum]>gi|270001551|gb|EEZ97998.1| hypothetical protein TcasGA2_TC000396 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BRH0 351 5.6e-32 Transmembrane and TPR repeat-containing protein 3 OS=Mus musculus GN=Tmtc3 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27521 BP_3 44.00 7.59 571 91081821 XP_976452.1 173 3.2e-10 PREDICTED: uncharacterized protein LOC663436 isoform X2 [Tribolium castaneum]>gi|270006302|gb|EFA02750.1| hypothetical protein TcasGA2_TC008483 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27523 BP_3 13.00 2.43 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27525 BP_3 291.84 2.99 4995 642910386 XP_969301.3 1715 4.4e-188 PREDICTED: ribonucleases P/MRP protein subunit POP1, partial [Tribolium castaneum] -- -- -- -- -- K06128 LYPLA1 lysophospholipase I http://www.genome.jp/dbget-bin/www_bget?ko:K06128 Q5RBR7 628 2.0e-63 Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1 PF08170//PF06978//PF01764//PF00326//PF10503//PF05577//PF07859//PF01738//PF02230 POPLD (NUC188) domain//Ribonucleases P/MRP protein subunit POP1//Lipase (class 3)//Prolyl oligopeptidase family//Esterase PHB depolymerase//Serine carboxypeptidase S28//alpha/beta hydrolase fold//Dienelactone hydrolase family//Phospholipase/Carboxylesterase GO:0008152//GO:0006629//GO:0006508//GO:0001682//GO:0008033//GO:0051252//GO:0006396 metabolic process//lipid metabolic process//proteolysis//tRNA 5'-leader removal//tRNA processing//regulation of RNA metabolic process//RNA processing GO:0016787//GO:0004526//GO:0008236 hydrolase activity//ribonuclease P activity//serine-type peptidase activity GO:0030677//GO:0005576 ribonuclease P complex//extracellular region KOG2112 Lysophospholipase Cluster-8309.27528 BP_3 658.00 18.21 2033 642917706 XP_008191338.1 1628 2.2e-178 PREDICTED: WD repeat-containing protein 43 [Tribolium castaneum] -- -- -- -- -- K14546 UTP5, WDR43 U3 small nucleolar RNA-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K14546 Q15061 707 5.7e-73 WD repeat-containing protein 43 OS=Homo sapiens GN=WDR43 PE=1 SV=3 PF09384//PF00400 UTP15 C terminal//WD domain, G-beta repeat GO:0006364 rRNA processing GO:0005515 protein binding GO:0005730 nucleolus KOG4547 WD40 repeat-containing protein Cluster-8309.2753 BP_3 9.67 0.56 1127 642914257 XP_008201609.1 655 8.2e-66 PREDICTED: transmembrane and TPR repeat-containing protein 1-like [Tribolium castaneum]>gi|270001551|gb|EEZ97998.1| hypothetical protein TcasGA2_TC000396 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BRH0 351 6.0e-32 Transmembrane and TPR repeat-containing protein 3 OS=Mus musculus GN=Tmtc3 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27532 BP_3 75.00 8.40 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27534 BP_3 166.00 2.41 3617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.27535 BP_3 235.58 2.53 4788 642915090 XP_008190408.1 1130 2.9e-120 PREDICTED: probable uridine-cytidine kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q9VC99 910 3.9e-96 Probable uridine-cytidine kinase OS=Drosophila melanogaster GN=CG6364 PE=3 SV=1 PF03810//PF02224//PF00437//PF07690//PF00083//PF09547//PF06414//PF01121//PF00485 Importin-beta N-terminal domain//Cytidylate kinase//Type II/IV secretion system protein//Major Facilitator Superfamily//Sugar (and other) transporter//Stage IV sporulation protein A (spore_IV_A)//Zeta toxin//Dephospho-CoA kinase//Phosphoribulokinase / Uridine kinase family GO:0006206//GO:0043934//GO:0008152//GO:0015937//GO:0015940//GO:0055085//GO:0006886//GO:0006139//GO:0006810 pyrimidine nucleobase metabolic process//sporulation//metabolic process//coenzyme A biosynthetic process//pantothenate biosynthetic process//transmembrane transport//intracellular protein transport//nucleobase-containing compound metabolic process//transport GO:0004140//GO:0022857//GO:0008536//GO:0016887//GO:0004127//GO:0016301//GO:0005524 dephospho-CoA kinase activity//transmembrane transporter activity//Ran GTPase binding//ATPase activity//cytidylate kinase activity//kinase activity//ATP binding GO:0016021 integral component of membrane KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.27536 BP_3 8.03 0.44 1169 642915092 XP_969315.3 409 2.8e-37 PREDICTED: probable uridine-cytidine kinase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q9VC99 369 5.1e-34 Probable uridine-cytidine kinase OS=Drosophila melanogaster GN=CG6364 PE=3 SV=1 PF00485 Phosphoribulokinase / Uridine kinase family GO:0008152 metabolic process GO:0016301//GO:0005524 kinase activity//ATP binding -- -- KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.27537 BP_3 862.97 12.61 3590 91091508 XP_969167.1 1943 1.2e-214 PREDICTED: protein LMBR1L isoform X2 [Tribolium castaneum]>gi|270000933|gb|EEZ97380.1| hypothetical protein TcasGA2_TC011205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 905 1.1e-95 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.27538 BP_3 31.77 0.43 3826 642936854 XP_008197915.1 1215 3.2e-130 PREDICTED: protein LMBR1L isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 579 7.4e-58 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.27539 BP_3 1374.00 32.75 2314 86515348 NP_001034501.1 1526 1.7e-166 extradenticle [Tribolium castaneum]>gi|38490515|emb|CAD57734.1| extradenticle [Tribolium castaneum] 332672665 HM157269.1 87 4.52816e-35 Sepia officinalis pre-B-cell leukemia transcription factor 1 (PBX1) mRNA, partial cds K09355 PBX1 pre-B-cell leukemia transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09355 P40427 1323 2.4e-144 Homeobox protein extradenticle OS=Drosophila melanogaster GN=exd PE=1 SV=1 PF04218//PF03792//PF01381//PF12844//PF05920//PF00046//PF00443//PF13443 CENP-B N-terminal DNA-binding domain//PBC domain//Helix-turn-helix//Helix-turn-helix domain//Homeobox KN domain//Homeobox domain//Ubiquitin carboxyl-terminal hydrolase//Cro/C1-type HTH DNA-binding domain GO:0006355//GO:0016579 regulation of transcription, DNA-templated//protein deubiquitination GO:0043565//GO:0003700//GO:0003677//GO:0036459 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//ubiquitinyl hydrolase activity GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0774 Transcription factor PBX and related HOX domain proteins Cluster-8309.27540 BP_3 52.19 0.55 4857 270005503 EFA01951.1 635 7.4e-63 hypothetical protein TcasGA2_TC007566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09197//PF04272 Rap1, DNA-binding//Phospholamban GO:0006810//GO:0006816 transport//calcium ion transport GO:0042030//GO:0003677//GO:0005246 ATPase inhibitor activity//DNA binding//calcium channel regulator activity GO:0016020 membrane -- -- Cluster-8309.27541 BP_3 370.58 4.42 4337 189237077 XP_968819.2 4221 0.0e+00 PREDICTED: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase [Tribolium castaneum]>gi|642922088|ref|XP_008193012.1| PREDICTED: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase [Tribolium castaneum]>gi|270007422|gb|EFA03870.1| hypothetical protein TcasGA2_TC013993 [Tribolium castaneum] -- -- -- -- -- K02577 NDST2 heparan sulfate N-deacetylase/N-sulfotransferase NDST2 http://www.genome.jp/dbget-bin/www_bget?ko:K02577 Q9V3L1 3430 0.0e+00 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase OS=Drosophila melanogaster GN=sfl PE=1 SV=1 PF12062//PF00685 heparan sulfate-N-deacetylase//Sulfotransferase domain -- -- GO:0008146//GO:0016787//GO:0015016 sulfotransferase activity//hydrolase activity//[heparan sulfate]-glucosamine N-sulfotransferase activity -- -- KOG3703 Heparan sulfate N-deacetylase/N-sulfotransferase Cluster-8309.27544 BP_3 77.00 3.59 1325 642913536 XP_008201054.1 326 1.4e-27 PREDICTED: uncharacterized protein C1orf131 [Tribolium castaneum]>gi|270002041|gb|EEZ98488.1| hypothetical protein TcasGA2_TC000985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15064 Cation channel sperm-associated protein subunit gamma -- -- -- -- GO:0036128//GO:0097228 CatSper complex//sperm principal piece -- -- Cluster-8309.27545 BP_3 140.00 6.06 1405 642913536 XP_008201054.1 326 1.4e-27 PREDICTED: uncharacterized protein C1orf131 [Tribolium castaneum]>gi|270002041|gb|EEZ98488.1| hypothetical protein TcasGA2_TC000985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15064 Cation channel sperm-associated protein subunit gamma -- -- -- -- GO:0097228//GO:0036128 sperm principal piece//CatSper complex -- -- Cluster-8309.27548 BP_3 30.26 1.02 1720 478255841 ENN76049.1 1123 6.7e-120 hypothetical protein YQE_07422, partial [Dendroctonus ponderosae] -- -- -- -- -- K08669 HTRA2, PRSS25 HtrA serine peptidase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08669 B4JTT7 954 1.1e-101 Serine protease HTRA2, mitochondrial OS=Drosophila grimshawi GN=HtrA2 PE=3 SV=1 PF00089//PF05579//PF10459 Trypsin//Equine arteritis virus serine endopeptidase S32//Peptidase S46 GO:0006508//GO:0016032//GO:0019082 proteolysis//viral process//viral protein processing GO:0070009//GO:0008239//GO:0004252 serine-type aminopeptidase activity//dipeptidyl-peptidase activity//serine-type endopeptidase activity -- -- KOG1320 Serine protease Cluster-8309.2755 BP_3 32.51 1.09 1730 270011134 EFA07582.1 1117 3.4e-119 invected [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27551 BP_3 16.41 2.42 618 332375664 AEE62973.1 288 1.6e-23 unknown [Dendroctonus ponderosae]>gi|478254613|gb|ENN74856.1| hypothetical protein YQE_08626, partial [Dendroctonus ponderosae]>gi|546673364|gb|ERL84987.1| hypothetical protein D910_02410 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZC48 229 4.6e-18 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4320 Uncharacterized conserved protein Cluster-8309.27552 BP_3 352.22 10.92 1846 91089167 XP_974028.1 1509 1.3e-164 PREDICTED: DNA-directed RNA polymerase III subunit RPC5 [Tribolium castaneum]>gi|270011487|gb|EFA07935.1| hypothetical protein TcasGA2_TC005516 [Tribolium castaneum] -- -- -- -- -- K14721 RPC5, POLR3E DNA-directed RNA polymerase III subunit RPC5 http://www.genome.jp/dbget-bin/www_bget?ko:K14721 Q9NVU0 686 1.4e-70 DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens GN=POLR3E PE=1 SV=1 PF05132//PF04801 RNA polymerase III RPC4//Sin-like protein conserved region GO:0006206//GO:0006351//GO:0006383//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005666//GO:0005730//GO:0005634 DNA-directed RNA polymerase III complex//nucleolus//nucleus KOG2354 RNA Polymerase C (III) 37 kDa subunit Cluster-8309.27553 BP_3 114.19 6.18 1182 91079136 XP_975456.1 331 3.2e-28 PREDICTED: uncharacterized protein LOC664352 [Tribolium castaneum]>gi|270003627|gb|EFA00075.1| hypothetical protein TcasGA2_TC002890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27554 BP_3 605.50 4.53 6733 91076704 XP_972106.1 1365 2.3e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 7.1e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF00175//PF00892//PF01297//PF10147//PF13371//PF08449//PF08030//PF04142 Oxidoreductase NAD-binding domain//EamA-like transporter family//Zinc-uptake complex component A periplasmic//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//Tetratricopeptide repeat//UAA transporter family//Ferric reductase NAD binding domain//Nucleotide-sugar transporter GO:0008643//GO:0055114//GO:0007049//GO:0015780//GO:0055085//GO:0030001 carbohydrate transport//oxidation-reduction process//cell cycle//nucleotide-sugar transport//transmembrane transport//metal ion transport GO:0005338//GO:0046872//GO:0005515//GO:0016491//GO:0005351 nucleotide-sugar transmembrane transporter activity//metal ion binding//protein binding//oxidoreductase activity//sugar:proton symporter activity GO:0016020//GO:0000139//GO:0016021//GO:0005634 membrane//Golgi membrane//integral component of membrane//nucleus KOG2234 Predicted UDP-galactose transporter Cluster-8309.27556 BP_3 440.88 13.25 1896 642919850 XP_008192095.1 1809 2.1e-199 PREDICTED: protein tumorous imaginal discs, mitochondrial isoform X1 [Tribolium castaneum] 642919851 XM_968364.3 179 2.66321e-86 PREDICTED: Tribolium castaneum protein tumorous imaginal discs, mitochondrial (LOC662253), transcript variant X2, mRNA K09504 DNAJA3 DnaJ homolog subfamily A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09504 Q24331 1402 1.4e-153 Protein tumorous imaginal discs, mitochondrial OS=Drosophila virilis GN=l(2)tid PE=2 SV=1 PF00684 DnaJ central domain -- -- GO:0051082//GO:0031072 unfolded protein binding//heat shock protein binding -- -- KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.2756 BP_3 142.62 0.99 7265 642923970 XP_008193945.1 2257 9.1e-251 PREDICTED: hydrocephalus-inducing protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W93 1207 2.1e-130 Hydrocephalus-inducing protein OS=Mus musculus GN=Hydin PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27560 BP_3 2.00 0.53 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27562 BP_3 9.91 0.87 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27563 BP_3 18.70 0.63 1732 646710939 KDR16317.1 278 6.5e-22 Eukaryotic translation initiation factor 3 subunit G [Zootermopsis nevadensis] -- -- -- -- -- K03248 EIF3G translation initiation factor 3 subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K03248 Q9VDM6 248 8.1e-20 Eukaryotic translation initiation factor 3 subunit G-2 OS=Drosophila melanogaster GN=eIF3-S4-2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.27564 BP_3 585.17 28.25 1290 270011668 EFA08116.1 382 4.2e-34 hypothetical protein TcasGA2_TC005720 [Tribolium castaneum] -- -- -- -- -- K14325 RNPS1 RNA-binding protein with serine-rich domain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14325 Q3KPW1 288 1.4e-24 RNA-binding protein with serine-rich domain 1-B OS=Xenopus laevis GN=rnps1-b PE=2 SV=1 PF09726//PF00076//PF16367 Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.27565 BP_3 131.68 6.44 1278 270011668 EFA08116.1 382 4.2e-34 hypothetical protein TcasGA2_TC005720 [Tribolium castaneum] -- -- -- -- -- K14325 RNPS1 RNA-binding protein with serine-rich domain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14325 Q3KPW1 288 1.4e-24 RNA-binding protein with serine-rich domain 1-B OS=Xenopus laevis GN=rnps1-b PE=2 SV=1 PF10486//PF16367//PF00076//PF09726 Phosphoinositide 3-kinase gamma adapter protein p101 subunit//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein -- -- GO:0003676//GO:0046935 nucleic acid binding//1-phosphatidylinositol-3-kinase regulator activity GO:0005944//GO:0016021 phosphatidylinositol 3-kinase complex, class IB//integral component of membrane KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.27566 BP_3 8.25 0.36 1402 270011668 EFA08116.1 382 4.6e-34 hypothetical protein TcasGA2_TC005720 [Tribolium castaneum] -- -- -- -- -- K14325 RNPS1 RNA-binding protein with serine-rich domain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14325 Q3KPW1 288 1.5e-24 RNA-binding protein with serine-rich domain 1-B OS=Xenopus laevis GN=rnps1-b PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.27567 BP_3 173.22 2.02 4424 642937862 XP_008200329.1 2459 2.1e-274 PREDICTED: PHD finger protein 19 [Tribolium castaneum]>gi|270000755|gb|EEZ97202.1| hypothetical protein TcasGA2_TC004391 [Tribolium castaneum] -- -- -- -- -- K11485 MTF2, PCL2 polycomb-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11485 Q9Y483 739 2.4e-76 Metal-response element-binding transcription factor 2 OS=Homo sapiens GN=MTF2 PE=1 SV=2 PF00130//PF00628//PF05191 Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//Adenylate kinase, active site lid GO:0006144//GO:0035556//GO:0046034 purine nucleobase metabolic process//intracellular signal transduction//ATP metabolic process GO:0004017//GO:0005515 adenylate kinase activity//protein binding -- -- -- -- Cluster-8309.27571 BP_3 389.38 22.50 1126 189233795 XP_973362.2 594 9.7e-59 PREDICTED: FUN14 domain-containing protein 1-like isoform X1 [Tribolium castaneum]>gi|642910988|ref|XP_008193497.1| PREDICTED: FUN14 domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17986 FUNDC1 FUN14 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17986 Q4RY26 198 3.3e-14 FUN14 domain-containing protein 1 OS=Tetraodon nigroviridis GN=fundc1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4099 Predicted membrane protein Cluster-8309.27574 BP_3 197.58 6.40 1780 189240485 XP_967921.2 1610 2.4e-176 PREDICTED: poly(A)-specific ribonuclease PARN [Tribolium castaneum]>gi|270011407|gb|EFA07855.1| hypothetical protein TcasGA2_TC005425 [Tribolium castaneum] -- -- -- -- -- K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 P69341 1069 5.2e-115 Poly(A)-specific ribonuclease PARN OS=Bos taurus GN=PARN PE=1 SV=2 PF14993//PF04857//PF08675//PF05669//PF01424 Neuropeptide S precursor protein//CAF1 family ribonuclease//RNA binding domain//SOH1//R3H domain GO:0051252//GO:0006355//GO:0007218//GO:0006402 regulation of RNA metabolic process//regulation of transcription, DNA-templated//neuropeptide signaling pathway//mRNA catabolic process GO:0046872//GO:0003676//GO:0004535//GO:0003723//GO:0001104 metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity//RNA binding//RNA polymerase II transcription cofactor activity GO:0005737//GO:0005576//GO:0044424//GO:0016592//GO:0005634 cytoplasm//extracellular region//intracellular part//mediator complex//nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.27575 BP_3 9.93 0.36 1610 189240485 XP_967921.2 1230 2.5e-132 PREDICTED: poly(A)-specific ribonuclease PARN [Tribolium castaneum]>gi|270011407|gb|EFA07855.1| hypothetical protein TcasGA2_TC005425 [Tribolium castaneum] -- -- -- -- -- K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 Q90ZA1 812 3.0e-85 Poly(A)-specific ribonuclease PARN OS=Xenopus laevis GN=parn PE=1 SV=1 PF01424//PF04857 R3H domain//CAF1 family ribonuclease -- -- GO:0003676 nucleic acid binding GO:0005634//GO:0044424 nucleus//intracellular part KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.2758 BP_3 89.33 1.85 2618 642911634 XP_968416.2 2461 7.3e-275 PREDICTED: serine proteinase stubble [Tribolium castaneum] 815914183 XM_012386953.1 264 2.07274e-133 PREDICTED: Bombus impatiens serine proteinase stubble (LOC100748461), mRNA -- -- -- -- P03952 424 4.8e-40 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.27580 BP_3 36.65 0.80 2507 157121106 XP_001659828.1 222 2.9e-15 AAEL009212-PE [Aedes aegypti]>gi|108874721|gb|EAT38946.1| AAEL009212-PE [Aedes aegypti] -- -- -- -- -- -- -- -- -- P56671 137 8.7e-07 Myc-associated zinc finger protein OS=Mus musculus GN=Maz PE=1 SV=1 PF13465//PF00096//PF10403//PF05829//PF13912//PF00643//PF14634 Zinc-finger double domain//Zinc finger, C2H2 type//Rad4 beta-hairpin domain 1//Adenovirus late L2 mu core protein (Protein X)//C2H2-type zinc finger//B-box zinc finger//zinc-RING finger domain -- -- GO:0003677//GO:0008270//GO:0046872//GO:0005515 DNA binding//zinc ion binding//metal ion binding//protein binding GO:0005622//GO:0019013 intracellular//viral nucleocapsid KOG1721 FOG: Zn-finger Cluster-8309.27581 BP_3 16.90 0.64 1559 91095059 XP_972457.1 767 1.2e-78 PREDICTED: uroporphyrinogen decarboxylase [Tribolium castaneum] -- -- -- -- -- K01599 hemE, UROD uroporphyrinogen decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01599 Q9V595 590 1.6e-59 Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=3 SV=1 PF01208 Uroporphyrinogen decarboxylase (URO-D) GO:0006779//GO:0015994 porphyrin-containing compound biosynthetic process//chlorophyll metabolic process GO:0004853 uroporphyrinogen decarboxylase activity -- -- KOG2872 Uroporphyrinogen decarboxylase Cluster-8309.27582 BP_3 1121.38 48.81 1399 91095059 XP_972457.1 1421 1.5e-154 PREDICTED: uroporphyrinogen decarboxylase [Tribolium castaneum] -- -- -- -- -- K01599 hemE, UROD uroporphyrinogen decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01599 Q9V595 1159 1.5e-125 Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=3 SV=1 PF01208 Uroporphyrinogen decarboxylase (URO-D) GO:0015994//GO:0006779 chlorophyll metabolic process//porphyrin-containing compound biosynthetic process GO:0004853 uroporphyrinogen decarboxylase activity -- -- KOG2872 Uroporphyrinogen decarboxylase Cluster-8309.27583 BP_3 51.31 1.69 1754 91095059 XP_972457.1 1269 8.1e-137 PREDICTED: uroporphyrinogen decarboxylase [Tribolium castaneum] -- -- -- -- -- K01599 hemE, UROD uroporphyrinogen decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01599 Q9V595 1002 3.0e-107 Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=3 SV=1 PF01208 Uroporphyrinogen decarboxylase (URO-D) GO:0015994//GO:0006779 chlorophyll metabolic process//porphyrin-containing compound biosynthetic process GO:0004853 uroporphyrinogen decarboxylase activity -- -- KOG2872 Uroporphyrinogen decarboxylase Cluster-8309.27587 BP_3 29.83 0.43 3667 499003021 XP_004534983.1 376 6.0e-33 PREDICTED: estrogen sulfotransferase [Ceratitis capitata] -- -- -- -- -- K01025 E2.8.2.- -- http://www.genome.jp/dbget-bin/www_bget?ko:K01025 Q9WUW8 209 5.7e-15 Sulfotransferase 1C2 OS=Rattus norvegicus GN=Sult1c2 PE=2 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.27589 BP_3 147.02 5.60 1557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2759 BP_3 12.60 0.55 1400 642911411 XP_008199411.1 848 4.2e-88 PREDICTED: lachesin-like isoform X1 [Tribolium castaneum] 642911414 XM_008201191.1 46 1.67913e-12 PREDICTED: Tribolium castaneum lachesin-like (LOC661289), transcript variant X3, mRNA -- -- -- -- Q24372 196 7.0e-14 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27590 BP_3 45.00 1.64 1614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27591 BP_3 271.68 22.07 885 642921732 XP_008199304.1 654 8.4e-66 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 488 6.1e-48 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.27592 BP_3 9.97 0.99 777 91083773 XP_972220.1 272 1.5e-21 PREDICTED: uncharacterized protein LOC660933 [Tribolium castaneum]>gi|270006783|gb|EFA03231.1| hypothetical protein TcasGA2_TC013160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27593 BP_3 325.00 33.31 762 91086169 XP_970456.1 741 5.9e-76 PREDICTED: nucleolysin TIAR [Tribolium castaneum]>gi|270010230|gb|EFA06678.1| hypothetical protein TcasGA2_TC009608 [Tribolium castaneum] 642927790 XM_965363.2 109 8.52536e-48 PREDICTED: Tribolium castaneum nucleolysin TIAR (LOC659024), mRNA K13201 TIA1, TIAL1 nucleolysin TIA-1/TIAR http://www.genome.jp/dbget-bin/www_bget?ko:K13201 Q01085 451 1.0e-43 Nucleolysin TIAR OS=Homo sapiens GN=TIAL1 PE=1 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily) Cluster-8309.27595 BP_3 10.00 4.11 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27596 BP_3 272.37 1.84 7438 189241728 XP_966529.2 2295 3.7e-255 PREDICTED: polycomb protein Scm [Tribolium castaneum] 817209209 XM_012425227.1 101 2.42459e-42 PREDICTED: Orussus abietinus polycomb protein Scm-like (LOC105699853), transcript variant X3, mRNA K11461 SCMH1 polycomb protein SCMH1 http://www.genome.jp/dbget-bin/www_bget?ko:K11461 Q9VHA0 1384 6.5e-151 Polycomb protein Scm OS=Drosophila melanogaster GN=Scm PE=1 SV=2 PF07647//PF00536//PF02069//PF02820//PF03145//PF06467 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Prokaryotic metallothionein//mbt repeat//Seven in absentia protein family//MYM-type Zinc finger with FCS sequence motif GO:0006511//GO:0006355//GO:0007275 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated//multicellular organismal development GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.27598 BP_3 17.99 1.18 1028 768441002 XP_011562202.1 212 1.7e-14 PREDICTED: hyphally regulated cell wall protein 1-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.27599 BP_3 59.85 1.02 3110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.276 BP_3 6.00 2.50 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2760 BP_3 5.59 0.31 1156 260831005 XP_002610450.1 232 9.4e-17 hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae]>gi|229295816|gb|EEN66460.1| hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.27602 BP_3 221.06 2.78 4129 270001519 EEZ97966.1 2063 1.6e-228 hypothetical protein TcasGA2_TC000358 [Tribolium castaneum] 462381540 APGK01021978.1 59 2.98674e-19 Dendroctonus ponderosae Seq01021988, whole genome shotgun sequence K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 571 6.8e-57 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF07926//PF00005//PF08702//PF13851//PF06810//PF06160//PF10473//PF11365//PF00769//PF05557//PF06220//PF02050//PF04111//PF09730//PF13443//PF01576 TPR/MLP1/MLP2-like protein//ABC transporter//Fibrinogen alpha/beta chain family//Growth-arrest specific micro-tubule binding//Phage minor structural protein GP20//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Mitotic checkpoint protein//U1 zinc finger//Flagellar FliJ protein//Autophagy protein Apg6//Microtubule-associated protein Bicaudal-D//Cro/C1-type HTH DNA-binding domain//Myosin tail GO:0030168//GO:0006935//GO:0048870//GO:0000921//GO:0071973//GO:0006606//GO:0010506//GO:0007094//GO:0007165//GO:0006810//GO:0006914//GO:0051258 platelet activation//chemotaxis//cell motility//septin ring assembly//bacterial-type flagellum-dependent cell motility//protein import into nucleus//regulation of autophagy//mitotic spindle assembly checkpoint//signal transduction//transport//autophagy//protein polymerization GO:0003774//GO:0030674//GO:0008092//GO:0016887//GO:0005102//GO:0005524//GO:0045502//GO:0008134//GO:0042803//GO:0008270//GO:0043565//GO:0005198 motor activity//protein binding, bridging//cytoskeletal protein binding//ATPase activity//receptor binding//ATP binding//dynein binding//transcription factor binding//protein homodimerization activity//zinc ion binding//sequence-specific DNA binding//structural molecule activity GO:0030286//GO:0005667//GO:0009288//GO:0005577//GO:0005615//GO:0019898//GO:0005794//GO:0016020//GO:0005737//GO:0016459//GO:0031514//GO:0016021//GO:0005940 dynein complex//transcription factor complex//bacterial-type flagellum//fibrinogen complex//extracellular space//extrinsic component of membrane//Golgi apparatus//membrane//cytoplasm//myosin complex//motile cilium//integral component of membrane//septin ring -- -- Cluster-8309.27605 BP_3 62.81 0.35 8917 642926988 XP_008195092.1 1922 7.8e-212 PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum]>gi|642926990|ref|XP_008195093.1| PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum] 642926985 XM_008196869.1 122 6.16488e-54 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX27 (LOC103313489), mRNA K01320 F7 coagulation factor VII http://www.genome.jp/dbget-bin/www_bget?ko:K01320 P21902 337 2.0e-29 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF02468//PF00089 Photosystem II reaction centre N protein (psbN)//Trypsin GO:0006508//GO:0015979 proteolysis//photosynthesis GO:0004252 serine-type endopeptidase activity GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.27609 BP_3 8587.16 212.33 2241 546681042 ERL91207.1 2449 1.5e-273 hypothetical protein D910_08545 [Dendroctonus ponderosae] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10714 1662 1.1e-183 Angiotensin-converting enzyme OS=Drosophila melanogaster GN=Ance PE=1 SV=3 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.27610 BP_3 1472.52 17.61 4323 91076900 XP_975025.1 1414 3.1e-153 PREDICTED: Y+L amino acid transporter 2 [Tribolium castaneum] 817087970 XM_012411364.1 68 3.10625e-24 PREDICTED: Athalia rosae Y+L amino acid transporter 2 (LOC105692280), transcript variant X4, mRNA K13872 SLC7A6 solute carrier family 7 (L-type amino acid transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13872 Q8BGK6 858 3.7e-90 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF00324//PF01424//PF01990//PF13520 Amino acid permease//R3H domain//ATP synthase (F/14-kDa) subunit//Amino acid permease GO:0034220//GO:0006810//GO:0055085//GO:0006865//GO:0003333 ion transmembrane transport//transport//transmembrane transport//amino acid transport//amino acid transmembrane transport GO:0015171//GO:0003676 amino acid transmembrane transporter activity//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.27611 BP_3 534.16 4.25 6355 189237853 XP_974947.2 2561 4.5e-286 PREDICTED: protein abrupt isoform X1 [Tribolium castaneum]>gi|642924667|ref|XP_008194388.1| PREDICTED: protein abrupt isoform X1 [Tribolium castaneum]>gi|642924669|ref|XP_008194389.1| PREDICTED: protein abrupt isoform X1 [Tribolium castaneum]>gi|642924671|ref|XP_008194390.1| PREDICTED: protein abrupt isoform X1 [Tribolium castaneum] 642924672 XM_969854.3 737 0 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X4, mRNA -- -- -- -- Q24174 724 1.9e-74 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF00651//PF02892//PF00096 BTB/POZ domain//BED zinc finger//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.27612 BP_3 3.00 0.32 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27613 BP_3 134.34 4.81 1639 642912019 XP_008199062.1 1896 1.5e-209 PREDICTED: calcium uptake protein 3, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86XE3 901 1.5e-95 Calcium uptake protein 3, mitochondrial OS=Homo sapiens GN=MICU3 PE=2 SV=1 PF13405//PF13833//PF00036//PF13499//PF13202//PF12763 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27616 BP_3 710.69 5.23 6842 546681938 ERL91934.1 5335 0.0e+00 hypothetical protein D910_09257, partial [Dendroctonus ponderosae] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 O88572 3260 0.0e+00 Low-density lipoprotein receptor-related protein 6 OS=Mus musculus GN=Lrp6 PE=1 SV=1 PF06320//PF02244//PF12859//PF00057 GCN5-like protein 1 (GCN5L1)//Carboxypeptidase activation peptide//Anaphase-promoting complex subunit 1//Low-density lipoprotein receptor domain class A GO:0006508 proteolysis GO:0004180//GO:0005515 carboxypeptidase activity//protein binding GO:0031083//GO:0005680 BLOC-1 complex//anaphase-promoting complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.27618 BP_3 7.80 0.69 833 -- -- -- -- -- 642938590 XM_008201633.1 47 2.73362e-13 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF06459//PF15785 Ryanodine Receptor TM 4-6//Serine/threonine-protein kinase smg-1 GO:0016310//GO:0000184//GO:0009069//GO:0006816//GO:0006874 phosphorylation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//serine family amino acid metabolic process//calcium ion transport//cellular calcium ion homeostasis GO:0005219//GO:0004674 ryanodine-sensitive calcium-release channel activity//protein serine/threonine kinase activity GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.27619 BP_3 63.00 2.45 1530 478257211 ENN77374.1 627 2.0e-62 hypothetical protein YQE_06199, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6NRD5 176 1.6e-11 Exonuclease 3'-5' domain-containing protein 1 OS=Xenopus laevis GN=exd1 PE=2 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding -- -- -- -- Cluster-8309.2762 BP_3 45.41 1.82 1493 642930071 XP_008196238.1 169 2.5e-09 PREDICTED: proline-rich protein 4, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27620 BP_3 62.63 1.21 2780 646702398 KDR11610.1 775 2.5e-79 GTP-binding protein Rheb-like protein [Zootermopsis nevadensis] 556946329 XM_005986343.1 39 2.62711e-08 PREDICTED: Latimeria chalumnae GTP-binding protein Rheb-like (LOC102353752), mRNA K07208 RHEB Ras homolog enriched in brain http://www.genome.jp/dbget-bin/www_bget?ko:K07208 Q9VND8 675 4.0e-69 GTP-binding protein Rheb homolog OS=Drosophila melanogaster GN=Rheb PE=2 SV=1 PF00071//PF00025//PF01926//PF01637//PF08477//PF03193 Ras family//ADP-ribosylation factor family//50S ribosome-binding GTPase//Archaeal ATPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.27622 BP_3 1065.95 18.60 3054 328722814 XP_001942735.2 1153 4.0e-123 PREDICTED: endothelin-converting enzyme 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P42893 533 1.3e-52 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.27624 BP_3 68.96 1.98 1972 676472292 XP_009059444.1 402 3.1e-36 hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea]>gi|556101324|gb|ESO89976.1| hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea] -- -- -- -- -- -- -- -- -- Q5MCW4 395 8.3e-37 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF00096//PF13465//PF05443//PF13912//PF02892//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.27625 BP_3 19.55 1.09 1159 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15704 Mitochondrial ATP synthase subunit GO:0009555 pollen development -- -- -- -- -- -- Cluster-8309.27626 BP_3 689.06 4.17 8262 270016796 EFA13242.1 3554 0.0e+00 hypothetical protein TcasGA2_TC001512 [Tribolium castaneum] 642938255 XM_008199910.1 478 0 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O35598 1514 6.1e-166 Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus GN=Adam10 PE=1 SV=2 PF01562//PF07988//PF01421 Reprolysin family propeptide//LMSTEN motif//Reprolysin (M12B) family zinc metalloprotease GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.2763 BP_3 5.95 4.41 352 765144722 XP_011483321.1 226 1.4e-16 PREDICTED: transposase isoform X1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- Q9UJ78 191 6.7e-14 Zinc finger MYM-type protein 5 OS=Homo sapiens GN=ZMYM5 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27632 BP_3 2221.53 45.89 2625 642925731 XP_008201510.1 490 2.6e-46 PREDICTED: snRNA-activating protein complex subunit 1-like [Tribolium castaneum]>gi|270008917|gb|EFA05365.1| hypothetical protein TcasGA2_TC015530 [Tribolium castaneum] 830186132 XM_004692871.2 69 5.21942e-25 PREDICTED: Condylura cristata vesicle-associated membrane protein 1 (synaptobrevin 1) (VAMP1), mRNA K13505 VAMP3 vesicle-associated membrane protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13505 O02495 252 4.2e-20 Synaptobrevin-1 OS=Caenorhabditis elegans GN=snb-1 PE=1 SV=1 PF01555//PF10717//PF00957 DNA methylase//Occlusion-derived virus envelope protein ODV-E18//Synaptobrevin GO:0016192//GO:0006306 vesicle-mediated transport//DNA methylation GO:0003677//GO:0008170 DNA binding//N-methyltransferase activity GO:0016021//GO:0019031 integral component of membrane//viral envelope KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.27633 BP_3 120.75 2.62 2513 91082929 XP_972879.1 1013 5.6e-107 PREDICTED: ubiquitin-conjugating enzyme E2Q-like protein CG4502 [Tribolium castaneum]>gi|270007616|gb|EFA04064.1| hypothetical protein TcasGA2_TC014298 [Tribolium castaneum] 195117381 XM_002003190.1 85 6.36902e-34 Drosophila mojavensis GI17799 (Dmoj\GI17799), mRNA K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q9VM35 678 1.6e-69 Ubiquitin-conjugating enzyme E2Q-like protein CG4502 OS=Drosophila melanogaster GN=CG4502 PE=2 SV=1 PF05997 Nucleolar protein,Nop52 GO:0006364 rRNA processing GO:0016881 acid-amino acid ligase activity GO:0030688 preribosome, small subunit precursor KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.27634 BP_3 36.25 0.72 2727 91082929 XP_972879.1 1013 6.1e-107 PREDICTED: ubiquitin-conjugating enzyme E2Q-like protein CG4502 [Tribolium castaneum]>gi|270007616|gb|EFA04064.1| hypothetical protein TcasGA2_TC014298 [Tribolium castaneum] 195117381 XM_002003190.1 85 6.91431e-34 Drosophila mojavensis GI17799 (Dmoj\GI17799), mRNA K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q9VM35 678 1.8e-69 Ubiquitin-conjugating enzyme E2Q-like protein CG4502 OS=Drosophila melanogaster GN=CG4502 PE=2 SV=1 PF05997 Nucleolar protein,Nop52 GO:0006364 rRNA processing GO:0016881 acid-amino acid ligase activity GO:0030688 preribosome, small subunit precursor KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.27635 BP_3 1.00 1.65 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P81592 126 2.0e-06 Acaloleptin A OS=Acalolepta luxuriosa PE=1 SV=2 PF06286 Coleoptericin GO:0042742 defense response to bacterium -- -- GO:0005576 extracellular region -- -- Cluster-8309.27636 BP_3 10.00 39.26 271 642938419 XP_008199794.1 234 1.3e-17 PREDICTED: coleoptericin-like [Tribolium castaneum]>gi|270015406|gb|EFA11854.1| hypothetical protein TcasGA2_TC005096 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81592 444 2.4e-43 Acaloleptin A OS=Acalolepta luxuriosa PE=1 SV=2 PF06286 Coleoptericin GO:0042742 defense response to bacterium -- -- GO:0005576 extracellular region -- -- Cluster-8309.27639 BP_3 38.00 1.00 2121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2764 BP_3 1.05 0.63 369 765144722 XP_011483321.1 251 1.9e-19 PREDICTED: transposase isoform X1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- Q9UJ78 202 3.7e-15 Zinc finger MYM-type protein 5 OS=Homo sapiens GN=ZMYM5 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27640 BP_3 271.26 2.28 6037 642915750 XP_008190789.1 4116 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.37904e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.6e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.27642 BP_3 106.78 11.85 726 642922287 XP_008193094.1 465 5.7e-44 PREDICTED: calcium uptake protein 1 homolog, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2VEI2 313 9.8e-28 Calcium uptake protein 1 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4495 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27643 BP_3 525.92 5.99 4522 642922287 XP_008193094.1 1398 2.3e-151 PREDICTED: calcium uptake protein 1 homolog, mitochondrial isoform X2 [Tribolium castaneum] 827547479 XM_004926405.2 135 1.84862e-61 PREDICTED: Bombyx mori calcium uptake protein 1 homolog, mitochondrial-like (LOC101741664), mRNA -- -- -- -- A2VEI2 1235 7.5e-134 Calcium uptake protein 1 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4495 PE=2 SV=1 PF13202//PF03854//PF00036//PF12763//PF10591//PF13833//PF13405//PF13499 EF hand//P-11 zinc finger//EF hand//Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0008270//GO:0005509//GO:0003723//GO:0005515 zinc ion binding//calcium ion binding//RNA binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27644 BP_3 43.87 0.49 4597 642922287 XP_008193094.1 1219 1.3e-130 PREDICTED: calcium uptake protein 1 homolog, mitochondrial isoform X2 [Tribolium castaneum] 827547479 XM_004926405.2 135 1.87953e-61 PREDICTED: Bombyx mori calcium uptake protein 1 homolog, mitochondrial-like (LOC101741664), mRNA -- -- -- -- A2VEI2 1107 5.3e-119 Calcium uptake protein 1 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4495 PE=2 SV=1 PF12763//PF10591//PF13405//PF13833//PF13499//PF13202//PF00036//PF03854 Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF-hand domain pair//EF hand//EF hand//P-11 zinc finger GO:0007165 signal transduction GO:0005515//GO:0008270//GO:0005509//GO:0003723 protein binding//zinc ion binding//calcium ion binding//RNA binding GO:0005578 proteinaceous extracellular matrix KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27646 BP_3 32.34 0.39 4291 270007460 EFA03908.1 795 1.8e-81 hypothetical protein TcasGA2_TC014040 [Tribolium castaneum] 827547479 XM_004926405.2 87 8.45163e-35 PREDICTED: Bombyx mori calcium uptake protein 1 homolog, mitochondrial-like (LOC101741664), mRNA -- -- -- -- A2VEI2 697 1.7e-71 Calcium uptake protein 1 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4495 PE=2 SV=1 PF03854//PF13499//PF13833//PF00036//PF13405//PF13202 P-11 zinc finger//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//EF hand -- -- GO:0008270//GO:0003723//GO:0005509 zinc ion binding//RNA binding//calcium ion binding -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27649 BP_3 758.19 16.93 2450 642912453 XP_008200868.1 2147 1.7e-238 PREDICTED: transferrin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02942 730 1.5e-75 Transferrin OS=Blaberus discoidalis PE=1 SV=1 PF09445 RNA cap guanine-N2 methyltransferase GO:0009452//GO:0001510 7-methylguanosine RNA capping//RNA methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.2765 BP_3 6.00 1.79 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27653 BP_3 257.55 2.37 5538 189241624 XP_001807794.1 2521 1.7e-281 PREDICTED: chondroitin sulfate synthase 1 isoform X2 [Tribolium castaneum] 194768964 XM_001966545.1 131 3.79399e-59 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1685 6.1e-186 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF13506//PF05679//PF01762//PF02434 Glycosyl transferase family 21//Chondroitin N-acetylgalactosaminyltransferase//Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0008376//GO:0016757 galactosyltransferase activity//acetylgalactosaminyltransferase activity//transferase activity, transferring glycosyl groups GO:0032580//GO:0016020 Golgi cisterna membrane//membrane KOG3588 Chondroitin synthase 1 Cluster-8309.27654 BP_3 119.83 1.70 3684 270003083 EEZ99530.1 2054 1.6e-227 hypothetical protein TcasGA2_TC000112 [Tribolium castaneum] -- -- -- -- -- K13117 DHX35 ATP-dependent RNA helicase DDX35 http://www.genome.jp/dbget-bin/www_bget?ko:K13117 Q9H5Z1 1282 2.2e-139 Probable ATP-dependent RNA helicase DHX35 OS=Homo sapiens GN=DHX35 PE=1 SV=2 PF00400//PF04408//PF01436 WD domain, G-beta repeat//Helicase associated domain (HA2)//NHL repeat -- -- GO:0005515//GO:0004386 protein binding//helicase activity -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.27657 BP_3 814.24 2.07 19287 642929424 XP_008195834.1 3477 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X2 [Tribolium castaneum] 642929421 XM_008197611.1 179 2.75206e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q7TMR0 1024 9.4e-109 Lysosomal Pro-X carboxypeptidase OS=Mus musculus GN=Prcp PE=2 SV=2 PF00326//PF02891//PF00400//PF00130//PF00536//PF00439//PF00628//PF14634//PF04574//PF05577//PF16367//PF00076//PF04810//PF01221//PF08273//PF01429//PF07647//PF08926//PF11789//PF02198//PF04564//PF06638 Prolyl oligopeptidase family//MIZ/SP-RING zinc finger//WD domain, G-beta repeat//Phorbol esters/diacylglycerol binding domain (C1 domain)//SAM domain (Sterile alpha motif)//Bromodomain//PHD-finger//zinc-RING finger domain//Protein of unknown function (DUF592)//Serine carboxypeptidase S28//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Sec23/Sec24 zinc finger//Dynein light chain type 1//Zinc-binding domain of primase-helicase//Methyl-CpG binding domain//SAM domain (Sterile alpha motif)//Domain of unknown function (DUF1908)//Zinc-finger of the MIZ type in Nse subunit//Sterile alpha motif (SAM)/Pointed domain//U-box domain//Strabismus protein GO:0006468//GO:0009069//GO:0006886//GO:0007017//GO:0006355//GO:0006351//GO:0006476//GO:0006888//GO:0006807//GO:0006269//GO:0035556//GO:0006342//GO:0007275//GO:0016310//GO:0016567//GO:0006508 protein phosphorylation//serine family amino acid metabolic process//intracellular protein transport//microtubule-based process//regulation of transcription, DNA-templated//transcription, DNA-templated//protein deacetylation//ER to Golgi vesicle-mediated transport//nitrogen compound metabolic process//DNA replication, synthesis of RNA primer//intracellular signal transduction//chromatin silencing//multicellular organismal development//phosphorylation//protein ubiquitination//proteolysis GO:0016811//GO:0003896//GO:0017136//GO:0043565//GO:0008270//GO:0004386//GO:0003677//GO:0051287//GO:0005515//GO:0000287//GO:0005524//GO:0004674//GO:0008236//GO:0004842//GO:0003676 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//DNA primase activity//NAD-dependent histone deacetylase activity//sequence-specific DNA binding//zinc ion binding//helicase activity//DNA binding//NAD binding//protein binding//magnesium ion binding//ATP binding//protein serine/threonine kinase activity//serine-type peptidase activity//ubiquitin-protein transferase activity//nucleic acid binding GO:0005875//GO:0016021//GO:0030127//GO:0005657//GO:0005634//GO:0005730//GO:0000118 microtubule associated complex//integral component of membrane//COPII vesicle coat//replication fork//nucleus//nucleolus//histone deacetylase complex KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.27661 BP_3 762.26 8.04 4864 91090284 XP_971237.1 1565 1.1e-170 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q92667 500 1.4e-48 A-kinase anchor protein 1, mitochondrial OS=Homo sapiens GN=AKAP1 PE=1 SV=1 PF13014//PF00013 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.27662 BP_3 71.00 2.58 1616 642935122 XP_008197897.1 2599 4.5e-291 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 224 2.18388e-111 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 332 1.4e-29 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.27667 BP_3 94.94 1.52 3307 546685769 ERL95218.1 2384 7.8e-266 hypothetical protein D910_12485 [Dendroctonus ponderosae] 514694901 XM_004994965.1 65 1.10269e-22 Salpingoeca rosetta bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase mRNA K13811 PAPSS 3'-phosphoadenosine 5'-phosphosulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13811 O95340 2061 9.1e-230 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Homo sapiens GN=PAPSS2 PE=1 SV=2 PF01747//PF01583//PF01293 ATP-sulfurylase//Adenylylsulphate kinase//Phosphoenolpyruvate carboxykinase GO:0015976//GO:0006099//GO:0006094//GO:0006790//GO:0006144//GO:0000103 carbon utilization//tricarboxylic acid cycle//gluconeogenesis//sulfur compound metabolic process//purine nucleobase metabolic process//sulfate assimilation GO:0004612//GO:0005524//GO:0004781//GO:0004020 phosphoenolpyruvate carboxykinase (ATP) activity//ATP binding//sulfate adenylyltransferase (ATP) activity//adenylylsulfate kinase activity -- -- KOG4238 Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase Cluster-8309.27668 BP_3 471.26 2.85 8259 270002738 EEZ99185.1 1670 1.2e-182 serine protease H6 [Tribolium castaneum] 462358611 APGK01030035.1 93 7.54224e-38 Dendroctonus ponderosae Seq01030045, whole genome shotgun sequence -- -- -- -- E1BLP6 751 1.8e-77 AT-rich interactive domain-containing protein 5B OS=Bos taurus GN=ARID5B PE=3 SV=1 PF01388//PF04926//PF06090 ARID/BRIGHT DNA binding domain//Poly(A) polymerase predicted RNA binding domain//Inositol-pentakisphosphate 2-kinase GO:0043631 RNA polyadenylation GO:0003677//GO:0005524//GO:0003723//GO:0035299 DNA binding//ATP binding//RNA binding//inositol pentakisphosphate 2-kinase activity -- -- KOG2744 DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain Cluster-8309.27669 BP_3 19.07 0.64 1721 478258940 ENN78915.1 687 2.4e-69 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 Q5F4B1 410 1.3e-38 Phosphoglycolate phosphatase OS=Gallus gallus GN=PGP PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.27671 BP_3 283.45 5.80 2647 189239598 XP_967831.2 1055 8.0e-112 PREDICTED: CAAX prenyl protease 2 [Tribolium castaneum] -- -- -- -- -- K08658 RCE1, FACE2 prenyl protein peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08658 Q9U1H8 668 2.5e-68 CAAX prenyl protease 2 OS=Drosophila melanogaster GN=Sras PE=2 SV=3 PF02517 CAAX protease self-immunity -- -- -- -- GO:0016020 membrane KOG4130 Prenyl protein protease Cluster-8309.27678 BP_3 42.89 0.76 2996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27679 BP_3 10.00 0.63 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27680 BP_3 631.45 10.02 3328 91091390 XP_973483.1 1946 4.8e-215 PREDICTED: gametogenetin-binding protein 2-like [Tribolium castaneum]>gi|270014166|gb|EFA10614.1| hypothetical protein TcasGA2_TC012875 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNG1 907 6.0e-96 Gametogenetin-binding protein 2-like OS=Drosophila melanogaster GN=CG2182 PE=2 SV=3 PF15337 Vascular protein family Vasculin-like 1 GO:0006351//GO:0045893 transcription, DNA-templated//positive regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.27682 BP_3 1148.80 22.66 2735 642929623 XP_008195908.1 441 1.3e-40 PREDICTED: vegetative cell wall protein gp1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01132 Elongation factor P (EF-P) OB domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840 ribosome -- -- Cluster-8309.27683 BP_3 562.51 10.72 2822 91078176 XP_967241.1 2271 8.4e-253 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 1711 3.0e-189 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- GO:0006804//GO:0055114//GO:0006979 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress GO:0020037//GO:0004601 heme binding//peroxidase activity -- -- -- -- Cluster-8309.27684 BP_3 72.11 1.40 2776 242018392 XP_002429661.1 545 1.1e-52 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] 688552082 XM_009300990.1 38 9.43499e-08 PREDICTED: Danio rerio zinc finger protein 420-like (LOC100537687), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 O75373 527 5.8e-52 Zinc finger protein 737 OS=Homo sapiens GN=ZNF737 PE=2 SV=3 PF00096//PF13465//PF06467//PF13912//PF04810//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//MYM-type Zinc finger with FCS sequence motif//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.27686 BP_3 67.76 1.25 2914 189237508 XP_972374.2 634 5.8e-63 PREDICTED: protein D2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 484 5.9e-47 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.27687 BP_3 95.00 22.18 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01779 Ribosomal L29e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.27688 BP_3 34.37 2.84 874 642914372 XP_008201652.1 231 9.3e-17 PREDICTED: uncharacterized protein LOC659966 [Tribolium castaneum]>gi|270001589|gb|EEZ98036.1| hypothetical protein TcasGA2_TC000438 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.2769 BP_3 8.00 2.68 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27690 BP_3 49.78 2.04 1470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27694 BP_3 26.50 0.66 2220 642926100 XP_008194784.1 524 2.5e-50 PREDICTED: polycomb complex protein BMI-1-A [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 Q5R8L2 439 7.4e-42 Polycomb complex protein BMI-1 OS=Pongo abelii GN=BMI1 PE=2 SV=1 PF00946//PF03854//PF01213//PF10099//PF13639//PF03315//PF16685//PF00097//PF12678//PF14634//PF03341//PF11789 Mononegavirales RNA dependent RNA polymerase//P-11 zinc finger//Adenylate cyclase associated (CAP) N terminal//Anti-sigma-K factor rskA//Ring finger domain//Serine dehydratase beta chain//zinc RING finger of MSL2//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain//Poxvirus mRNA capping enzyme, small subunit//Zinc-finger of the MIZ type in Nse subunit GO:0006534//GO:0007010//GO:0006563//GO:0006094//GO:0006566//GO:0006144//GO:0006544//GO:0006370//GO:0009451 cysteine metabolic process//cytoskeleton organization//L-serine metabolic process//gluconeogenesis//threonine metabolic process//purine nucleobase metabolic process//glycine metabolic process//7-methylguanosine mRNA capping//RNA modification GO:0003779//GO:0005524//GO:0051539//GO:0003941//GO:0008270//GO:0061630//GO:0005515//GO:0003723//GO:0004482//GO:0046872//GO:0003968 actin binding//ATP binding//4 iron, 4 sulfur cluster binding//L-serine ammonia-lyase activity//zinc ion binding//ubiquitin protein ligase activity//protein binding//RNA binding//mRNA (guanine-N7-)-methyltransferase activity//metal ion binding//RNA-directed RNA polymerase activity GO:0016021//GO:0019012//GO:0005886//GO:0031379 integral component of membrane//virion//plasma membrane//RNA-directed RNA polymerase complex KOG2660 Locus-specific chromosome binding proteins Cluster-8309.27697 BP_3 258.39 3.02 4421 189240990 XP_968175.2 1469 1.3e-159 PREDICTED: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [Tribolium castaneum]>gi|270012986|gb|EFA09434.1| hypothetical protein TcasGA2_TC010646 [Tribolium castaneum] -- -- -- -- -- K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 P30153 728 4.5e-75 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens GN=PPP2R1A PE=1 SV=4 PF01365//PF06616//PF02985//PF03147 RIH domain//BsuBI/PstI restriction endonuclease C-terminus//HEAT repeat//Ferredoxin-fold anticodon binding domain GO:0006816//GO:0070588//GO:0009307//GO:0006571//GO:0008033//GO:0006432//GO:0009094//GO:0000162//GO:0006308 calcium ion transport//calcium ion transmembrane transport//DNA restriction-modification system//tyrosine biosynthetic process//tRNA processing//phenylalanyl-tRNA aminoacylation//L-phenylalanine biosynthetic process//tryptophan biosynthetic process//DNA catabolic process GO:0005524//GO:0005262//GO:0009036//GO:0003677//GO:0005515//GO:0000049//GO:0004826//GO:0000287 ATP binding//calcium channel activity//Type II site-specific deoxyribonuclease activity//DNA binding//protein binding//tRNA binding//phenylalanine-tRNA ligase activity//magnesium ion binding GO:0009328//GO:0009359//GO:0016020 phenylalanine-tRNA ligase complex//Type II site-specific deoxyribonuclease complex//membrane KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.27699 BP_3 77.00 3.80 1268 91091556 XP_966788.1 1132 4.5e-121 PREDICTED: coiled-coil domain-containing protein 130 homolog [Tribolium castaneum]>gi|270000917|gb|EEZ97364.1| hypothetical protein TcasGA2_TC011186 [Tribolium castaneum] -- -- -- -- -- K13115 CCDC130 coiled-coil domain-containing protein 130 http://www.genome.jp/dbget-bin/www_bget?ko:K13115 Q7K0F0 926 1.4e-98 Coiled-coil domain-containing protein 130 homolog OS=Drosophila melanogaster GN=CG15084 PE=2 SV=1 PF00569 Zinc finger, ZZ type -- -- GO:0008270 zinc ion binding -- -- KOG2990 C2C2-type Zn-finger protein Cluster-8309.2770 BP_3 2.00 0.87 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27702 BP_3 135.69 2.87 2568 642927029 XP_008195110.1 1077 2.2e-114 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U182 182 5.4e-12 CREB-regulated transcription coactivator 2 OS=Mus musculus GN=Crtc2 PE=1 SV=2 PF00170//PF12884 bZIP transcription factor//Transducer of regulated CREB activity, N terminus GO:0051289//GO:0006355 protein homotetramerization//regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0008140 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//cAMP response element binding protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.27704 BP_3 276.00 38.19 640 478259232 ENN79134.1 381 2.7e-34 hypothetical protein YQE_04320, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27706 BP_3 249.58 3.66 3580 642935662 XP_008198105.1 869 4.0e-90 PREDICTED: cytochrome b reductase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 2.7e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF01292//PF03188//PF00033 Prokaryotic cytochrome b561//Eukaryotic cytochrome b561//Cytochrome b/b6/petB GO:0006118//GO:0022904 obsolete electron transport//respiratory electron transport chain GO:0009055 electron carrier activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1619 Cytochrome b Cluster-8309.2771 BP_3 21.00 0.91 1403 694533759 XP_009494840.1 1411 2.2e-153 elongation factor 2 [Fonticula alba]>gi|627948416|gb|KCV70324.1| elongation factor 2 [Fonticula alba] 697069898 XM_009651838.1 1380 0 Verticillium dahliae VdLs.17 elongation factor 2 mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q96X45 1753 2.0e-194 Elongation factor 2 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cot-3 PE=3 SV=3 PF10662//PF01926 Ethanolamine utilisation - propanediol utilisation//50S ribosome-binding GTPase GO:0006576 cellular biogenic amine metabolic process GO:0005524//GO:0005525 ATP binding//GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8309.27710 BP_3 706.68 21.60 1869 282158077 NP_001164082.1 1654 2.0e-181 spatzle 6 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27711 BP_3 15.79 0.45 1993 642914252 XP_008201607.1 1658 7.2e-182 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|270001550|gb|EEZ97997.1| hypothetical protein TcasGA2_TC000395 [Tribolium castaneum] -- -- -- -- -- K00741 B3GNT1, B3GNT2 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00741 O43505 417 2.4e-39 Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens GN=B4GAT1 PE=1 SV=1 PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.27712 BP_3 180.89 17.19 799 91094239 XP_968325.1 484 3.9e-46 PREDICTED: ragulator complex protein LAMTOR3 [Tribolium castaneum]>gi|270016276|gb|EFA12722.1| hypothetical protein TcasGA2_TC002357 [Tribolium castaneum] -- -- -- -- -- K04370 MP1, MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04370 Q7T0V2 349 7.3e-32 Ragulator complex protein LAMTOR3-A OS=Xenopus laevis GN=lamtor3-a PE=2 SV=1 PF08923 Mitogen-activated protein kinase kinase 1 interacting GO:0032006 regulation of TOR signaling -- -- -- -- -- -- Cluster-8309.27717 BP_3 362.27 5.89 3255 332375404 AEE62843.1 1194 7.5e-128 unknown [Dendroctonus ponderosae] 642934692 XM_008199551.1 353 0 PREDICTED: Tribolium castaneum CUGBP Elav-like family member 1 (LOC660275), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q9IBD0 376 2.2e-34 CUGBP Elav-like family member 1 OS=Danio rerio GN=celf1 PE=1 SV=1 PF16367//PF08675//PF00076 RNA recognition motif//RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0003676//GO:0004535//GO:0046872//GO:0003723 nucleic acid binding//poly(A)-specific ribonuclease activity//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.27718 BP_3 32.66 0.42 4006 642926192 XP_008194823.1 1295 1.8e-139 PREDICTED: glycylpeptide N-tetradecanoyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K00671 E2.3.1.97, NMT glycylpeptide N-tetradecanoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00671 P30419 1051 1.4e-112 Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens GN=NMT1 PE=1 SV=2 PF07402//PF01233//PF13508//PF02799 Human herpesvirus U26 protein//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//Acetyltransferase (GNAT) domain//Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0004379 N-acetyltransferase activity//glycylpeptide N-tetradecanoyltransferase activity GO:0016021 integral component of membrane KOG2779 N-myristoyl transferase Cluster-8309.27719 BP_3 354.08 9.25 2137 642930395 XP_008196381.1 2106 8.7e-234 PREDICTED: SH3 domain-binding protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH82 583 1.4e-58 SH3 domain-binding protein 5-like OS=Xenopus tropicalis GN=sh3bp5l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.27720 BP_3 872.00 17.08 2753 642938847 XP_008200089.1 2696 4.3e-302 PREDICTED: pre-rRNA-processing protein TSR1 homolog [Tribolium castaneum]>gi|270016043|gb|EFA12491.1| hypothetical protein TcasGA2_TC012891 [Tribolium castaneum] 525018632 XM_005056799.1 48 2.58292e-13 PREDICTED: Ficedula albicollis TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (TSR1), transcript variant X2, mRNA K14799 TSR1 pre-rRNA-processing protein TSR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14799 Q2NL82 1661 1.8e-183 Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens GN=TSR1 PE=1 SV=1 PF08142//PF01749 AARP2CN (NUC121) domain//Importin beta binding domain GO:0042254//GO:0015031//GO:0006606 ribosome biogenesis//protein transport//protein import into nucleus GO:0008565 protein transporter activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG1980 Uncharacterized conserved protein Cluster-8309.27722 BP_3 116.33 1.62 3760 478253990 ENN74282.1 1734 2.1e-190 hypothetical protein YQE_09254, partial [Dendroctonus ponderosae]>gi|546673736|gb|ERL85292.1| hypothetical protein D910_02713 [Dendroctonus ponderosae] -- -- -- -- -- K06639 CDC14 cell division cycle 14 http://www.genome.jp/dbget-bin/www_bget?ko:K06639 Q6GQT0 1212 2.9e-131 Dual specificity protein phosphatase CDC14A OS=Mus musculus GN=Cdc14a PE=2 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.27725 BP_3 3.00 0.83 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27728 BP_3 137.69 5.19 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27730 BP_3 13.20 0.68 1233 91091818 XP_966528.1 682 6.6e-69 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 434 1.6e-41 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF00060 Ligand-gated ion channel GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0004970//GO:0005216 ionotropic glutamate receptor activity//ion channel activity GO:0016020 membrane -- -- Cluster-8309.27731 BP_3 2659.45 46.30 3060 270006239 EFA02687.1 3258 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1457 9.2e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02180//PF02854//PF02020 Bcl-2 homology region 4//MIF4G domain//eIF4-gamma/eIF5/eIF2-epsilon GO:0042981 regulation of apoptotic process GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.27733 BP_3 49.54 1.34 2075 478257813 ENN77956.1 1793 1.7e-197 hypothetical protein YQE_05633, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 325 1.1e-28 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27734 BP_3 238.50 2.73 4498 642937240 XP_008198752.1 2109 8.2e-234 PREDICTED: chondroitin sulfate synthase 1 isoform X1 [Tribolium castaneum] 194768964 XM_001966545.1 122 3.09869e-54 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1272 3.8e-138 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF02434//PF01762//PF05679//PF13506 Fringe-like//Galactosyltransferase//Chondroitin N-acetylgalactosaminyltransferase//Glycosyl transferase family 21 GO:0006486 protein glycosylation GO:0008378//GO:0008376//GO:0016757 galactosyltransferase activity//acetylgalactosaminyltransferase activity//transferase activity, transferring glycosyl groups GO:0032580//GO:0016020 Golgi cisterna membrane//membrane KOG3588 Chondroitin synthase 1 Cluster-8309.27736 BP_3 78.00 8.62 728 751795220 XP_011207369.1 345 4.7e-30 PREDICTED: uncharacterized protein LOC105229022 [Bactrocera dorsalis] -- -- -- -- -- K06560 MRC mannose receptor, C type http://www.genome.jp/dbget-bin/www_bget?ko:K06560 P22897 178 4.4e-12 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27737 BP_3 412.00 38.17 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27738 BP_3 134.39 5.37 1497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27739 BP_3 43.00 4.92 713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27740 BP_3 40.14 0.65 3246 189234454 XP_967960.2 146 2.5e-06 PREDICTED: aldehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270002022|gb|EEZ98469.1| hypothetical protein TcasGA2_TC000960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27741 BP_3 117.88 0.37 15772 826444743 XP_012531039.1 5876 0.0e+00 PREDICTED: voltage-dependent calcium channel type A subunit alpha-1 isoform X7 [Monomorium pharaonis] 259906454 NM_001165911.1 940 0 Tribolium castaneum cacophony A (Cac), mRNA >gnl|BL_ORD_ID|7385018 Tribolium castaneum cacophony A (CAC) mRNA, complete cds -- -- -- -- C9D7C2 3178 0.0e+00 Voltage-dependent calcium channel type A subunit alpha-1 OS=Apis mellifera GN=CAC PE=2 SV=1 PF00230//PF02561//PF14138//PF00036//PF13405//PF01635//PF00520 Major intrinsic protein//Flagellar protein FliS//Cytochrome c oxidase assembly protein COX16//EF hand//EF-hand domain//Coronavirus M matrix/glycoprotein//Ion transport protein GO:0006810//GO:0019058//GO:0055085//GO:0006811 transport//viral life cycle//transmembrane transport//ion transport GO:0005215//GO:0005216//GO:0005509 transporter activity//ion channel activity//calcium ion binding GO:0031966//GO:0016020//GO:0009288 mitochondrial membrane//membrane//bacterial-type flagellum KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.27742 BP_3 406.58 3.12 6568 642923720 XP_008193855.1 1439 5.9e-156 PREDICTED: extended synaptotagmin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0FGR8 565 5.4e-56 Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2 PE=1 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.27744 BP_3 1.00 0.50 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27745 BP_3 12.18 0.37 1866 189241787 XP_969759.2 1119 2.1e-119 PREDICTED: cell division cycle protein 16 homolog [Tribolium castaneum] -- -- -- -- -- K03353 APC6, CDC16 anaphase-promoting complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03353 Q8R349 476 3.2e-46 Cell division cycle protein 16 homolog OS=Mus musculus GN=Cdc16 PE=2 SV=1 PF13181//PF13174//PF13414//PF04049 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Anaphase promoting complex subunit 8 / Cdc23 GO:0030071 regulation of mitotic metaphase/anaphase transition GO:0005515 protein binding GO:0005680 anaphase-promoting complex KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit Cluster-8309.27746 BP_3 351.81 10.22 1951 546682805 ERL92694.1 1690 1.4e-185 hypothetical protein D910_10005 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01939 866 2.0e-91 Protein misato OS=Drosophila melanogaster GN=mst PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG2530 Members of tubulin/FtsZ family Cluster-8309.27747 BP_3 78.00 5.29 1003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27748 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11789 Zinc-finger of the MIZ type in Nse subunit -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.27750 BP_3 16.00 17.30 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27751 BP_3 391.01 5.50 3719 642930416 XP_008196392.1 1551 3.4e-169 PREDICTED: stAR-related lipid transfer protein 3 [Tribolium castaneum]>gi|270011106|gb|EFA07554.1| Start1 [Tribolium castaneum] 768450242 XM_011568950.1 44 5.85883e-11 PREDICTED: Plutella xylostella MLN64 N-terminal domain homolog (LOC105396938), mRNA -- -- -- -- Q9DFS4 623 5.7e-63 StAR-related lipid transfer protein 3 OS=Danio rerio GN=stard3 PE=2 SV=2 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG3845 MLN, STAR and related lipid-binding proteins Cluster-8309.27752 BP_3 6.40 3.41 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04824 Conserved region of Rad21 / Rec8 like protein -- -- -- -- GO:0000228 nuclear chromosome -- -- Cluster-8309.27753 BP_3 31.00 2.71 843 321473458 EFX84425.1 547 2.0e-53 hypothetical protein DAPPUDRAFT_230610 [Daphnia pulex] -- -- -- -- -- K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 P29522 499 3.1e-49 Elongation factor 1-beta' OS=Bombyx mori PE=1 SV=2 PF00736 EF-1 guanine nucleotide exchange domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005853//GO:0005840 eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.27754 BP_3 520.00 21.00 1485 644993225 XP_008203138.1 149 5.1e-07 PREDICTED: mucin-12 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- P35074 133 1.5e-06 DNA-directed RNA polymerase II subunit RPB1 OS=Caenorhabditis briggsae GN=rpb-1 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27757 BP_3 12.21 0.68 1152 642929207 XP_008195736.1 155 7.9e-08 PREDICTED: protein CDV3 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27758 BP_3 636.00 8.18 4040 546681035 ERL91200.1 1188 4.6e-127 hypothetical protein D910_08539 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8K1A0 628 1.6e-63 Methyltransferase-like protein 5 OS=Mus musculus GN=Mettl5 PE=2 SV=2 PF05175//PF02390//PF00628//PF15925//PF03602//PF02384//PF09445 Methyltransferase small domain//Putative methyltransferase//PHD-finger//SOSS complex subunit C//Conserved hypothetical protein 95//N-6 DNA Methylase//RNA cap guanine-N2 methyltransferase GO:0009451//GO:0006400//GO:0006306//GO:0009452//GO:0001510//GO:0008033//GO:0006974//GO:0031167//GO:0006281 RNA modification//tRNA modification//DNA methylation//7-methylguanosine RNA capping//RNA methylation//tRNA processing//cellular response to DNA damage stimulus//rRNA methylation//DNA repair GO:0008176//GO:0003677//GO:0005515//GO:0008168//GO:0008170 tRNA (guanine-N7-)-methyltransferase activity//DNA binding//protein binding//methyltransferase activity//N-methyltransferase activity GO:0005634//GO:0070876 nucleus//SOSS complex KOG3420 Predicted RNA methylase Cluster-8309.2776 BP_3 1.00 0.44 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27763 BP_3 245.00 7.29 1912 478257020 ENN77184.1 774 2.2e-79 hypothetical protein YQE_06322, partial [Dendroctonus ponderosae]>gi|546673257|gb|ERL84895.1| hypothetical protein D910_02318 [Dendroctonus ponderosae] -- -- -- -- -- K10580 UBE2N, BLU, UBC13 ubiquitin-conjugating enzyme E2 N http://www.genome.jp/dbget-bin/www_bget?ko:K10580 P35128 591 1.5e-59 Ubiquitin-conjugating enzyme E2 N OS=Drosophila melanogaster GN=ben PE=2 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.27764 BP_3 14.22 5.69 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27765 BP_3 13.19 0.38 1974 478256393 ENN76583.1 1676 5.8e-184 hypothetical protein YQE_07032, partial [Dendroctonus ponderosae]>gi|546680826|gb|ERL91032.1| hypothetical protein D910_08374 [Dendroctonus ponderosae] 167515085 EU267006.1 35 3.10739e-06 Aedes aegypti sodium-dependent nutrient amino acid transporter 8 (NAT8) mRNA, complete cds K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 B4MEG2 1183 3.5e-128 Sodium-dependent nutrient amino acid transporter 1 OS=Drosophila virilis GN=NAAT1 PE=3 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.27769 BP_3 36.38 6.26 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04851 Type III restriction enzyme, res subunit -- -- GO:0016787//GO:0003677//GO:0005524 hydrolase activity//DNA binding//ATP binding -- -- -- -- Cluster-8309.27772 BP_3 44.21 0.63 3675 642916459 XP_008191036.1 2113 2.3e-234 PREDICTED: sestrin homolog [Tribolium castaneum]>gi|642916461|ref|XP_008191037.1| PREDICTED: sestrin homolog [Tribolium castaneum] 642916460 XM_008192815.1 526 0 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 P58003 755 2.8e-78 Sestrin-1 OS=Xenopus laevis GN=sesn1 PE=2 SV=1 PF04636 PA26 p53-induced protein (sestrin) GO:1901031 regulation of response to reactive oxygen species -- -- GO:0005634 nucleus KOG3746 Uncharacterized conserved protein Cluster-8309.27774 BP_3 11.00 0.55 1258 82795527 ABB91677.1 647 7.7e-65 arthrodial cuticle protein AMP16.5 [Callinectes sapidus] 82795526 DQ288152.1 467 0 Callinectes sapidus arthrodial cuticle protein AMP16.5 mRNA, complete cds -- -- -- -- P81577 303 2.5e-26 Cuticle protein AM1199 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.27775 BP_3 43.00 5.55 665 -- -- -- -- -- 392303562 JX102595.1 278 8.35657e-142 Scylla paramamosain microsatellite Spm24 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27778 BP_3 139.00 4.61 1744 170051568 XP_001861822.1 233 1.1e-16 predicted protein [Culex quinquefasciatus]>gi|167872759|gb|EDS36142.1| predicted protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.27779 BP_3 1810.74 41.10 2415 91077394 XP_975293.1 2103 2.2e-233 PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|642913902|ref|XP_008201207.1| PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|270001645|gb|EEZ98092.1| hypothetical protein TcasGA2_TC000505 [Tribolium castaneum] -- -- -- -- -- K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 P52170 1420 1.4e-155 Importin subunit alpha-5 OS=Xenopus laevis GN=kpna1 PE=1 SV=2 PF11698//PF00514//PF01602//PF02985//PF01749//PF10508 V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//HEAT repeat//Importin beta binding domain//Proteasome non-ATPase 26S subunit GO:0043248//GO:0006606//GO:0015031//GO:0006886//GO:0015991//GO:0016192 proteasome assembly//protein import into nucleus//protein transport//intracellular protein transport//ATP hydrolysis coupled proton transport//vesicle-mediated transport GO:0008565//GO:0016820//GO:0005515 protein transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0005737//GO:0030117//GO:0005634//GO:0000221 cytoplasm//membrane coat//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain KOG0166 Karyopherin (importin) alpha Cluster-8309.2778 BP_3 23.00 0.99 1416 642919725 XP_008192040.1 958 7.5e-101 PREDICTED: uncharacterized protein LOC103312654 [Tribolium castaneum]>gi|270005899|gb|EFA02347.1| hypothetical protein TcasGA2_TC008017 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05393//PF07525 Human adenovirus early E3A glycoprotein//SOCS box GO:0035556 intracellular signal transduction -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27787 BP_3 58.00 2.13 1604 768956561 XP_003977419.2 688 1.7e-69 PREDICTED: LOW QUALITY PROTEIN: histone H3.3 [Takifugu rubripes] 835961372 XM_012922313.1 242 2.13686e-121 PREDICTED: Maylandia zebra histone H3.3 (LOC101481297), mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P84249 676 1.8e-69 Histone H3.3 OS=Drosophila melanogaster GN=His3.3A PE=1 SV=2 PF00125//PF15715 Core histone H2A/H2B/H3/H4//PCNA-associated factor GO:0006974//GO:0051726 cellular response to DNA damage stimulus//regulation of cell cycle GO:0003677 DNA binding -- -- KOG1745 Histones H3 and H4 Cluster-8309.27788 BP_3 35.23 1.13 1797 91089625 XP_973443.1 740 1.8e-75 PREDICTED: tudor and KH domain-containing protein [Tribolium castaneum]>gi|270012611|gb|EFA09059.1| hypothetical protein TcasGA2_TC006774 [Tribolium castaneum] -- -- -- -- -- K18406 TDRKH, TDRD2 tudor domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18406 Q9Y2W6 235 2.7e-18 Tudor and KH domain-containing protein OS=Homo sapiens GN=TDRKH PE=1 SV=2 PF07650//PF00013//PF13184//PF13014 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.27790 BP_3 21.13 0.39 2875 91078976 XP_974454.1 1214 3.2e-130 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q68CP4 679 1.4e-69 Heparan-alpha-glucosaminide N-acetyltransferase OS=Homo sapiens GN=HGSNAT PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4683 Uncharacterized conserved protein Cluster-8309.27791 BP_3 276.41 4.12 3529 546685279 ERL94806.1 3262 0.0e+00 hypothetical protein D910_12080 [Dendroctonus ponderosae] 815898007 XM_003485762.2 360 0 PREDICTED: Bombus impatiens cullin-4A (LOC100740815), mRNA K10609 CUL4 cullin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10609 A2A432 2575 2.4e-289 Cullin-4B OS=Mus musculus GN=Cul4b PE=1 SV=1 PF00888//PF07516 Cullin family//SecA Wing and Scaffold domain GO:0017038//GO:0006511 protein import//ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0016020 membrane KOG2166 Cullins Cluster-8309.27792 BP_3 439.04 6.46 3568 546685279 ERL94806.1 3262 0.0e+00 hypothetical protein D910_12080 [Dendroctonus ponderosae] 815898007 XM_003485762.2 360 0 PREDICTED: Bombus impatiens cullin-4A (LOC100740815), mRNA K10609 CUL4 cullin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10609 A2A432 2575 2.5e-289 Cullin-4B OS=Mus musculus GN=Cul4b PE=1 SV=1 PF07516//PF00888 SecA Wing and Scaffold domain//Cullin family GO:0006511//GO:0017038 ubiquitin-dependent protein catabolic process//protein import GO:0031625 ubiquitin protein ligase binding GO:0016020 membrane KOG2166 Cullins Cluster-8309.27793 BP_3 14.00 1.48 749 270001539 EEZ97986.1 181 5.0e-11 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] -- -- -- -- -- K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 -- -- -- -- -- -- -- -- -- -- -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.27796 BP_3 42.00 2.63 1060 871263751 XP_012943684.1 152 1.6e-07 PREDICTED: cell wall protein IFF6-like isoform X2 [Aplysia californica] -- -- -- -- -- -- -- -- -- O85467 132 1.4e-06 Spore germination protein GerIA OS=Bacillus cereus GN=gerIA PE=3 SV=1 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27798 BP_3 17.11 0.80 1327 820805582 AKG92782.1 332 2.7e-28 Pxs [Leptinotarsa decemlineata] 564234777 XM_006274259.1 76 3.34431e-29 PREDICTED: Alligator mississippiensis transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA K09070 TCF15, PARAXIS transcription factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09070 Q60539 244 1.8e-19 Transcription factor 15 OS=Mesocricetus auratus GN=TCF15 PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.27799 BP_3 6.01 0.81 648 91091194 XP_972244.1 205 7.1e-14 PREDICTED: superoxide dismutase [Cu-Zn] [Tribolium castaneum]>gi|270014236|gb|EFA10684.1| hypothetical protein TcasGA2_TC011675 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006801//GO:0055114 superoxide metabolic process//oxidation-reduction process GO:0046872//GO:0004784 metal ion binding//superoxide dismutase activity -- -- -- -- Cluster-8309.278 BP_3 11.00 0.37 1743 91087965 XP_973007.1 475 9.4e-45 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 [Tribolium castaneum]>gi|270012046|gb|EFA08494.1| hypothetical protein TcasGA2_TC006146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88703 217 3.2e-16 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Mus musculus GN=Hcn2 PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005737//GO:0005840 cytoplasm//ribosome KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain Cluster-8309.2780 BP_3 117.31 7.29 1067 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27802 BP_3 255.71 12.56 1273 91084021 XP_975350.1 307 2.1e-25 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 820852256 XM_003694739.2 73 1.49092e-27 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX23 (LOC100863532), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q5RC67 212 8.9e-16 Probable ATP-dependent RNA helicase DDX23 OS=Pongo abelii GN=DDX23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.27803 BP_3 234.00 17.43 939 91082839 XP_969776.1 693 2.7e-70 PREDICTED: 39S ribosomal protein L10, mitochondrial [Tribolium castaneum]>gi|270007593|gb|EFA04041.1| hypothetical protein TcasGA2_TC014272 [Tribolium castaneum] -- -- -- -- -- K02864 RP-L10, MRPL10, rplJ large subunit ribosomal protein L10 http://www.genome.jp/dbget-bin/www_bget?ko:K02864 Q29NV5 473 3.6e-46 39S ribosomal protein L10, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL10 PE=3 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular -- -- Cluster-8309.27805 BP_3 750.28 39.08 1217 189234118 XP_001811130.1 610 1.5e-60 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] 153907106 AK262902.1 41 8.75093e-10 Gryllus bimaculatus mRNA, GBcontig09763 -- -- -- -- -- -- -- -- PF05757 Oxygen evolving enhancer protein 3 (PsbQ) GO:0015979 photosynthesis GO:0005509 calcium ion binding GO:0009654//GO:0019898//GO:0009523 photosystem II oxygen evolving complex//extrinsic component of membrane//photosystem II -- -- Cluster-8309.27806 BP_3 398.76 6.04 3476 332373510 AEE61896.1 429 4.1e-39 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4QBN3 168 3.1e-10 Facilitated trehalose transporter Tret1-2 homolog OS=Drosophila simulans GN=Tret1-2 PE=3 SV=1 PF00636//PF08120//PF00083 Ribonuclease III domain//Tamulustoxin family//Sugar (and other) transporter GO:0055085//GO:0009405//GO:0006810//GO:0051252//GO:0006396 transmembrane transport//pathogenesis//transport//regulation of RNA metabolic process//RNA processing GO:0022857//GO:0003723//GO:0019870//GO:0004525 transmembrane transporter activity//RNA binding//potassium channel inhibitor activity//ribonuclease III activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.27807 BP_3 791.40 7.01 5732 642923519 XP_008193543.1 1676 1.7e-183 PREDICTED: coiled-coil domain-containing protein 6 isoform X1 [Tribolium castaneum] 817195200 XM_012417714.1 198 2.23384e-96 PREDICTED: Orussus abietinus coiled-coil domain-containing protein 6 (LOC105695793), mRNA K09288 CCDC6, PTC coiled-coil domain-containing protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09288 D3YZP9 962 4.3e-102 Coiled-coil domain-containing protein 6 OS=Mus musculus GN=Ccdc6 PE=1 SV=1 PF04434//PF04551//PF04647 SWIM zinc finger//GcpE protein//Accessory gene regulator B GO:0009372//GO:0055114//GO:0009405//GO:0016114 quorum sensing//oxidation-reduction process//pathogenesis//terpenoid biosynthetic process GO:0008270//GO:0008233//GO:0046429 zinc ion binding//peptidase activity//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity GO:0016021 integral component of membrane KOG2129 Uncharacterized conserved protein H4 Cluster-8309.27808 BP_3 10.00 19.74 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27809 BP_3 32.77 4.09 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2781 BP_3 4.00 0.38 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00878 Cation-independent mannose-6-phosphate receptor repeat GO:0006810 transport GO:0005215 transporter activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm -- -- Cluster-8309.27810 BP_3 214.44 2.10 5217 642916067 XP_970503.2 1479 1.1e-160 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270004116|gb|EFA00564.1| hypothetical protein TcasGA2_TC003434 [Tribolium castaneum] -- -- -- -- -- K14856 SDA1, SDAD1 protein SDA1 http://www.genome.jp/dbget-bin/www_bget?ko:K14856 Q7KKH3 1106 7.9e-119 Protein SDA1 homolog OS=Drosophila melanogaster GN=Mys45A PE=1 SV=1 PF07690//PF06839//PF01733//PF01306 Major Facilitator Superfamily//GRF zinc finger//Nucleoside transporter//LacY proton/sugar symporter GO:0055085//GO:0015858//GO:0006810 transmembrane transport//nucleoside transport//transport GO:0008270//GO:0005337 zinc ion binding//nucleoside transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2229 Protein required for actin cytoskeleton organization and cell cycle progression Cluster-8309.27814 BP_3 391.65 8.67 2469 642920044 XP_008192181.1 163 2.0e-08 PREDICTED: uncharacterized protein LOC103312680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.27819 BP_3 24.94 1.21 1284 459485591 AGG68958.1 1339 4.5e-145 prohibitin-1 [Leptinotarsa decemlineata] 459485590 JX275964.1 294 2.10899e-150 Leptinotarsa decemlineata prohibitin-1 mRNA, complete cds K17080 PHB1 prohibitin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17080 P24156 1162 6.2e-126 Protein l(2)37Cc OS=Drosophila melanogaster GN=l(2)37Cc PE=2 SV=2 PF03242 Late embryogenesis abundant protein GO:0006950 response to stress -- -- -- -- KOG3083 Prohibitin Cluster-8309.2782 BP_3 17.92 0.85 1311 91083843 XP_973852.1 327 1.0e-27 PREDICTED: larval cuticle protein LCP-30 [Tribolium castaneum]>gi|270006765|gb|EFA03213.1| hypothetical protein TcasGA2_TC013133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 239 6.8e-19 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF01588 Putative tRNA binding domain -- -- GO:0042302//GO:0000049 structural constituent of cuticle//tRNA binding -- -- -- -- Cluster-8309.27820 BP_3 183.00 9.67 1204 620695583 AHY22513.1 779 3.7e-80 ubiquitin C, partial [Dastarcus helophoroides] -- -- -- -- -- K06688 UBE2C, UBC11 ubiquitin-conjugating enzyme E2 C http://www.genome.jp/dbget-bin/www_bget?ko:K06688 Q9VTY6 588 2.1e-59 Ubiquitin-conjugating enzyme E2 C OS=Drosophila melanogaster GN=vih PE=1 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0005515 protein binding -- -- KOG0421 Ubiquitin-protein ligase Cluster-8309.27821 BP_3 54.36 0.69 4087 91080341 XP_974659.1 822 1.3e-84 PREDICTED: ADP-ribosylation factor GTPase-activating protein 2 [Tribolium castaneum]>gi|270005715|gb|EFA02163.1| hypothetical protein TcasGA2_TC007817 [Tribolium castaneum] -- -- -- -- -- K12493 ARFGAP2_3 ADP-ribosylation factor GTPase-activating protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12493 Q4R4C9 536 7.7e-53 ADP-ribosylation factor GTPase-activating protein 3 OS=Macaca fascicularis GN=ARFGAP3 PE=2 SV=1 PF01412//PF02130 Putative GTPase activating protein for Arf//Uncharacterized protein family UPF0054 GO:0006364 rRNA processing GO:0004222//GO:0005096 metalloendopeptidase activity//GTPase activator activity -- -- KOG0706 Predicted GTPase-activating protein Cluster-8309.27822 BP_3 72.00 4.22 1114 642923812 XP_974895.2 1188 1.3e-127 PREDICTED: probable tRNA(His) guanylyltransferase [Tribolium castaneum] -- -- -- -- -- K10761 THG1 tRNA(His) guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10761 Q9V3N8 855 2.1e-90 Probable tRNA(His) guanylyltransferase OS=Drosophila melanogaster GN=l(2)35Bc PE=2 SV=1 PF04446 tRNAHis guanylyltransferase GO:0006400 tRNA modification GO:0008193//GO:0000287 tRNA guanylyltransferase activity//magnesium ion binding -- -- KOG2721 Uncharacterized conserved protein Cluster-8309.27828 BP_3 52.16 0.40 6653 642931365 XP_008196548.1 4221 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X4 [Tribolium castaneum] 665401438 NM_166190.4 299 1.85502e-152 Drosophila melanogaster unc-104 ortholog (unc-104), transcript variant C, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 3274 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF05014//PF05171//PF10390//PF07353//PF06414//PF00498//PF00225 Nucleoside 2-deoxyribosyltransferase//Haemin-degrading HemS.ChuX domain//RNA polymerase II elongation factor ELL//Uroplakin II//Zeta toxin//FHA domain//Kinesin motor domain GO:0006826//GO:0061024//GO:0007017//GO:0009159//GO:0007018//GO:0006206//GO:0006368 iron ion transport//membrane organization//microtubule-based process//deoxyribonucleoside monophosphate catabolic process//microtubule-based movement//pyrimidine nucleobase metabolic process//transcription elongation from RNA polymerase II promoter GO:0016301//GO:0050144//GO:0005524//GO:0008017//GO:0003777//GO:0005515//GO:0070694 kinase activity//nucleoside deoxyribosyltransferase activity//ATP binding//microtubule binding//microtubule motor activity//protein binding//deoxyribonucleoside 5'-monophosphate N-glycosidase activity GO:0045298//GO:0005874//GO:0030176//GO:0008023 tubulin complex//microtubule//integral component of endoplasmic reticulum membrane//transcription elongation factor complex KOG0245 Kinesin-like protein Cluster-8309.27829 BP_3 1883.01 14.58 6515 91091256 XP_968850.1 1918 1.7e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.3e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF01398//PF00180//PF04117 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Isocitrate/isopropylmalate dehydrogenase//Mpv17 / PMP22 family GO:0006749//GO:0006102//GO:0019643//GO:0006099//GO:0055114 glutathione metabolic process//isocitrate metabolic process//reductive tricarboxylic acid cycle//tricarboxylic acid cycle//oxidation-reduction process GO:0005515//GO:0016616//GO:0051287//GO:0000287//GO:0004450 protein binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//magnesium ion binding//isocitrate dehydrogenase (NADP+) activity GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.27830 BP_3 39.00 2.56 1025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27831 BP_3 3.00 0.34 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27832 BP_3 24.33 0.77 1813 642926638 XP_008194951.1 1506 2.8e-164 PREDICTED: LOW QUALITY PROTEIN: DNA-binding protein Ets97D [Tribolium castaneum] -- -- -- -- -- K09441 GABPA GA-binding protein transcription factor, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K09441 Q04688 944 1.7e-100 DNA-binding protein Ets97D OS=Drosophila melanogaster GN=Ets97D PE=1 SV=2 PF02198//PF00178 Sterile alpha motif (SAM)/Pointed domain//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3806 Predicted transcription factor Cluster-8309.27833 BP_3 417.63 8.40 2687 642916843 XP_008199526.1 1113 1.5e-118 PREDICTED: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [Tribolium castaneum]>gi|270003073|gb|EEZ99520.1| hypothetical protein TcasGA2_TC000101 [Tribolium castaneum] 642916842 XM_008201304.1 242 3.60932e-121 PREDICTED: Tribolium castaneum N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (LOC656887), mRNA K01482 DDAH, ddaH dimethylargininase http://www.genome.jp/dbget-bin/www_bget?ko:K01482 O94760 547 2.7e-54 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Homo sapiens GN=DDAH1 PE=1 SV=3 PF03808 Glycosyl transferase WecB/TagA/CpsF family GO:0009058//GO:0006807 biosynthetic process//nitrogen compound metabolic process GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0005737 cytoplasm -- -- Cluster-8309.27838 BP_3 131.11 1.97 3496 642927860 XP_008195428.1 2686 7.9e-301 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X1 [Tribolium castaneum] 662183442 XM_008489250.1 117 1.44614e-51 PREDICTED: Diaphorina citri receptor-type tyrosine-protein phosphatase alpha (LOC103524239), mRNA K13297 PTPRT receptor-type tyrosine-protein phosphatase T http://www.genome.jp/dbget-bin/www_bget?ko:K13297 Q99M80 1000 1.0e-106 Receptor-type tyrosine-protein phosphatase T OS=Mus musculus GN=Ptprt PE=2 SV=2 PF00102//PF00041//PF00782//PF00641 Protein-tyrosine phosphatase//Fibronectin type III domain//Dual specificity phosphatase, catalytic domain//Zn-finger in Ran binding protein and others GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008270//GO:0005515//GO:0008138//GO:0004725 zinc ion binding//protein binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.2784 BP_3 42.23 0.39 5518 270010398 EFA06846.1 837 3.2e-86 hypothetical protein TcasGA2_TC009789 [Tribolium castaneum] 642928841 XM_008197363.1 164 1.70968e-77 PREDICTED: Tribolium castaneum uncharacterized LOC657427 (LOC657427), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF00951//PF01284 Arterivirus GL envelope glycoprotein//Membrane-associating domain -- -- -- -- GO:0016020//GO:0019031 membrane//viral envelope -- -- Cluster-8309.27840 BP_3 256.16 10.42 1477 270009427 EFA05875.1 831 4.2e-86 hypothetical protein TcasGA2_TC008684 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48815 257 6.2e-21 Alcohol dehydrogenase 2 OS=Ceratitis capitata GN=ADH2 PE=3 SV=1 PF01370//PF00106//PF01073 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008152//GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 metabolic process//estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.27843 BP_3 35.51 0.64 2968 642928356 XP_008195548.1 966 1.9e-101 PREDICTED: abhydrolase domain-containing protein 4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K13699 ABHD5, CGI-58 abhydrolase domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13699 Q9DBL9 560 9.2e-56 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 OS=Mus musculus GN=Abhd5 PE=1 SV=1 PF03403//PF07859//PF02230//PF07819//PF01764//PF16929 Platelet-activating factor acetylhydrolase, isoform II//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//PGAP1-like protein//Lipase (class 3)//Accessory Sec system GspB-transporter GO:0046486//GO:0015031//GO:0016042//GO:0006629//GO:0006886//GO:0008152//GO:0006505 glycerolipid metabolic process//protein transport//lipid catabolic process//lipid metabolic process//intracellular protein transport//metabolic process//GPI anchor metabolic process GO:0016788//GO:0003847//GO:0016787 hydrolase activity, acting on ester bonds//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.27845 BP_3 103.99 7.53 957 478252070 ENN72501.1 747 1.5e-76 hypothetical protein YQE_10842, partial [Dendroctonus ponderosae] 831293719 XM_012823057.1 42 1.90054e-10 PREDICTED: Clupea harengus cullin 2 (cul2), mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 553 1.9e-55 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.27846 BP_3 16.63 0.60 1631 91093477 XP_968017.1 1155 1.2e-123 PREDICTED: U5 small nuclear ribonucleoprotein 40 kDa protein [Tribolium castaneum]>gi|270012667|gb|EFA09115.1| hypothetical protein TcasGA2_TC015975 [Tribolium castaneum] -- -- -- -- -- K12857 SNRNP40, PRP8BP Prp8 binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K12857 Q96DI7 975 3.8e-104 U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens GN=SNRNP40 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0265 U5 snRNP-specific protein-like factor and related proteins Cluster-8309.27847 BP_3 5.00 2.41 390 154414622 XP_001580338.1 141 1.1e-06 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121914554|gb|EAY19352.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q5U312 147 9.3e-09 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.2785 BP_3 14.00 0.75 1193 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27852 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27853 BP_3 14.94 0.31 2623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27856 BP_3 85.00 2.27 2096 815923661 XP_012246577.1 144 2.7e-06 PREDICTED: piggyBac transposable element-derived protein 4-like [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27857 BP_3 66.90 1.40 2595 189238410 XP_001813192.1 388 1.7e-34 PREDICTED: uncharacterized protein LOC100141684 [Tribolium castaneum]>gi|270008536|gb|EFA04984.1| hypothetical protein TcasGA2_TC015062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27858 BP_3 49.27 0.88 2983 189238410 XP_001813192.1 320 1.5e-26 PREDICTED: uncharacterized protein LOC100141684 [Tribolium castaneum]>gi|270008536|gb|EFA04984.1| hypothetical protein TcasGA2_TC015062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27859 BP_3 609.39 6.78 4622 642923482 XP_008193528.1 1562 2.3e-170 PREDICTED: hyccin [Tribolium castaneum] 642923486 XM_008195309.1 166 1.10565e-78 PREDICTED: Tribolium castaneum RNA binding protein fox-1 homolog 3 (LOC655682), transcript variant X3, mRNA -- -- -- -- Q9BYI3 417 5.5e-39 Hyccin OS=Homo sapiens GN=FAM126A PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.27861 BP_3 11.00 9.95 338 123494860 XP_001326609.1 231 3.6e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 189 1.1e-13 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27863 BP_3 28.00 0.50 2971 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27864 BP_3 16.13 0.56 1686 91087837 XP_967757.1 1141 5.4e-122 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 536 3.2e-53 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.27866 BP_3 530.80 4.02 6650 642915750 XP_008190789.1 4165 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.82411e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.8e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.2787 BP_3 1395.00 17.00 4248 478262486 ENN81157.1 2543 3.7e-284 hypothetical protein YQE_02523, partial [Dendroctonus ponderosae]>gi|546672798|gb|ERL84554.1| hypothetical protein D910_01983 [Dendroctonus ponderosae] 662217201 XM_008484351.1 320 2.50347e-164 PREDICTED: Diaphorina citri uncharacterized LOC103519265 (LOC103519265), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27870 BP_3 376.29 3.30 5785 478251697 ENN72151.1 1102 6.2e-117 hypothetical protein YQE_11208, partial [Dendroctonus ponderosae]>gi|546680949|gb|ERL91123.1| hypothetical protein D910_08464 [Dendroctonus ponderosae] 817214294 XM_012427986.1 53 9.08091e-16 PREDICTED: Orussus abietinus F-box only protein 28 (LOC105701325), transcript variant X4, mRNA K10306 FBXO28 F-box protein 28 http://www.genome.jp/dbget-bin/www_bget?ko:K10306 Q9NVF7 311 1.3e-26 F-box only protein 28 OS=Homo sapiens GN=FBXO28 PE=1 SV=1 PF15966//PF00646//PF13013//PF02601//PF01702//PF12937//PF01496//PF10186 F-box//F-box domain//F-box-like domain//Exonuclease VII, large subunit//Queuine tRNA-ribosyltransferase//F-box-like//V-type ATPase 116kDa subunit family//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0015992//GO:0006308//GO:0006400//GO:0010508//GO:0015991//GO:0008616 proton transport//DNA catabolic process//tRNA modification//positive regulation of autophagy//ATP hydrolysis coupled proton transport//queuosine biosynthetic process GO:0015078//GO:0008855//GO:0005515//GO:0008479 hydrogen ion transmembrane transporter activity//exodeoxyribonuclease VII activity//protein binding//queuine tRNA-ribosyltransferase activity GO:0033179//GO:0009318 proton-transporting V-type ATPase, V0 domain//exodeoxyribonuclease VII complex -- -- Cluster-8309.27871 BP_3 2.22 0.39 564 270010103 EFA06551.1 206 4.8e-14 hypothetical protein TcasGA2_TC009460 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VCH8 131 9.7e-07 UBX domain-containing protein 4 OS=Mus musculus GN=Ubxn4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27872 BP_3 1425.98 17.22 4282 91089973 XP_973833.1 4993 0.0e+00 PREDICTED: exportin-1 [Tribolium castaneum]>gi|270013547|gb|EFA09995.1| hypothetical protein TcasGA2_TC012162 [Tribolium castaneum] 462343018 APGK01035523.1 865 0 Dendroctonus ponderosae Seq01035533, whole genome shotgun sequence K14290 XPO1, CRM1 exportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14290 Q80U96 4220 0.0e+00 Exportin-1 OS=Rattus norvegicus GN=Xpo1 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008536//GO:0008565 Ran GTPase binding//protein transporter activity GO:0005643 nuclear pore KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.27873 BP_3 1047.70 10.72 5004 642939010 XP_008197770.1 3998 0.0e+00 PREDICTED: exportin-4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0E2 1978 5.8e-220 Exportin-4 OS=Homo sapiens GN=XPO4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily) Cluster-8309.27874 BP_3 127.91 2.34 2930 478261784 ENN80919.1 1237 6.9e-133 hypothetical protein YQE_02668, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IUS5 436 2.2e-41 Epoxide hydrolase 4 OS=Homo sapiens GN=EPHX4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4178 Soluble epoxide hydrolase Cluster-8309.27875 BP_3 504.57 10.59 2589 546684133 ERL93838.1 1454 4.2e-158 hypothetical protein D910_11124, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IUS5 505 1.9e-49 Epoxide hydrolase 4 OS=Homo sapiens GN=EPHX4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4178 Soluble epoxide hydrolase Cluster-8309.27876 BP_3 1.00 13.75 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27877 BP_3 29.10 0.32 4728 642914198 XP_008201586.1 1943 1.5e-214 PREDICTED: uncharacterized protein LOC661711 isoform X2 [Tribolium castaneum] 642914197 XM_008203364.1 324 1.66658e-166 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.9e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF00018//PF15360//PF00536//PF07647 SH3 domain//APJ endogenous ligand//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0007165 signal transduction GO:0005515//GO:0005179//GO:0031704 protein binding//hormone activity//apelin receptor binding -- -- -- -- Cluster-8309.27878 BP_3 3.00 0.77 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27880 BP_3 116.75 12.72 734 642921130 XP_975383.3 522 1.4e-50 PREDICTED: glutaredoxin-related protein 5, mitochondrial [Tribolium castaneum] 705677805 XM_010119203.1 44 1.11424e-11 PREDICTED: Chlamydotis macqueenii glutaredoxin 5 (GLRX5), partial mRNA K07390 grxD, GLRX5 monothiol glutaredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K07390 Q86SX6 461 6.9e-45 Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens GN=GLRX5 PE=1 SV=2 PF00462 Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG0911 Glutaredoxin-related protein Cluster-8309.27881 BP_3 233.00 6.54 2009 780074942 XP_011672046.1 260 9.3e-20 PREDICTED: ankyrin repeat domain-containing protein 17-like [Strongylocentrotus purpuratus] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q4UMH6 215 6.3e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27882 BP_3 25.00 7.99 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27884 BP_3 115.78 9.44 883 91082383 XP_968748.1 728 2.2e-74 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 469 9.8e-46 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF10766//PF00664 Multidrug efflux pump-associated protein AcrZ//ABC transporter transmembrane region GO:0006810//GO:0006855//GO:0055085//GO:0015893 transport//drug transmembrane transport//transmembrane transport//drug transport GO:0015238//GO:0005524//GO:0017111//GO:0042626 drug transmembrane transporter activity//ATP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.27885 BP_3 28.51 0.55 2782 91082383 XP_968748.1 1577 2.5e-172 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1057 2.0e-113 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF10598//PF00437//PF00004//PF13304//PF00664//PF00931//PF02367//PF03193//PF00005 RNA recognition motif of the spliceosomal PrP8//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0055085//GO:0002949 transport//transmembrane transport//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0043531//GO:0005524//GO:0003723//GO:0017111//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ADP binding//ATP binding//RNA binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.27887 BP_3 120.77 0.85 7171 91089099 XP_971819.1 8644 0.0e+00 PREDICTED: serine/threonine-protein kinase mTOR [Tribolium castaneum]>gi|270011516|gb|EFA07964.1| hypothetical protein TcasGA2_TC005546 [Tribolium castaneum] 242011951 XM_002426662.1 83 2.37042e-32 Pediculus humanus corporis Phosphatidylinositol 3-kinase tor2, putative, mRNA K07203 FRAP FKBP12-rapamycin complex-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K07203 Q9VK45 6618 0.0e+00 Target of rapamycin OS=Drosophila melanogaster GN=Tor PE=1 SV=1 PF00454//PF08771//PF01602//PF13176//PF02260//PF02985//PF02259 Phosphatidylinositol 3- and 4-kinase//Rapamycin binding domain//Adaptin N terminal region//Tetratricopeptide repeat//FATC domain//HEAT repeat//FAT domain GO:0016310//GO:0006886//GO:0016192 phosphorylation//intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0008144//GO:0005524//GO:0016301//GO:0016773 protein binding//drug binding//ATP binding//kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0030117 membrane coat KOG0891 DNA-dependent protein kinase Cluster-8309.27888 BP_3 346.93 21.88 1056 546676952 ERL87876.1 1259 7.0e-136 hypothetical protein D910_05264 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 629 3.3e-64 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01700//PF01073//PF01370 Orbivirus VP3 (T2) protein//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008210 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//estrogen metabolic process GO:0003854//GO:0003824//GO:0050662//GO:0016616//GO:0005198 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural molecule activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.27891 BP_3 1582.48 40.29 2185 859132801 AKO63316.1 1777 1.3e-195 acetyl CoA acetyltransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 1402 1.6e-153 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF00108//PF02803 Thiolase, N-terminal domain//Thiolase, C-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.27892 BP_3 4.00 36.08 246 340385288 XP_003391142.1 196 3.0e-13 PREDICTED: ankyrin-1-like [Amphimedon queenslandica] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q8C8R3 168 2.2e-11 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27893 BP_3 79.10 0.97 4240 642927970 XP_972030.2 2630 3.0e-294 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 255552749 XM_002517372.1 35 6.73511e-06 Ricinus communis mannosidase alpha class 2a, putative, mRNA K01231 MAN2 alpha-mannosidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01231 Q24451 1715 1.5e-189 Alpha-mannosidase 2 OS=Drosophila melanogaster GN=alpha-Man-II PE=1 SV=2 PF09261//PF01074//PF08053//PF07748 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 N-terminal domain//Tryptophanase operon leader peptide//Glycosyl hydrolases family 38 C-terminal domain GO:0006013//GO:0005975//GO:0031556//GO:0031554 mannose metabolic process//carbohydrate metabolic process//transcriptional attenuation by ribosome//regulation of DNA-templated transcription, termination GO:0008270//GO:0004559//GO:0015923//GO:0004553 zinc ion binding//alpha-mannosidase activity//mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.27895 BP_3 3.25 0.38 704 642932789 XP_008196985.1 488 1.2e-46 PREDICTED: fibroblast growth factor 1-like [Tribolium castaneum]>gi|270012810|gb|EFA09258.1| fibroblast growth factor 1 [Tribolium castaneum] -- -- -- -- -- K18496 FGF1 fibroblast growth factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18496 P61148 227 8.9e-18 Fibroblast growth factor 1 OS=Mus musculus GN=Fgf1 PE=2 SV=1 PF00167//PF06268 Fibroblast growth factor//Fascin domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0030674//GO:0008083//GO:0051015 protein binding, bridging//growth factor activity//actin filament binding -- -- -- -- Cluster-8309.27898 BP_3 363.52 8.66 2316 189240973 XP_967534.2 2131 1.2e-236 PREDICTED: TNF receptor-associated factor 4 isoform X1 [Tribolium castaneum] 817199300 XM_012419904.1 272 6.53686e-138 PREDICTED: Orussus abietinus TNF receptor-associated factor 4 (LOC105696990), transcript variant X2, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 1116 2.4e-120 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF02176//PF00096//PF15965//PF03145 TRAF-type zinc finger//Zinc finger, C2H2 type//TRAF-like zinc-finger//Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG0297 TNF receptor-associated factor Cluster-8309.279 BP_3 17.00 1.59 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2790 BP_3 5.28 0.39 941 321465971 EFX76969.1 863 5.2e-90 hypothetical protein DAPPUDRAFT_321849 [Daphnia pulex] -- -- -- -- -- -- -- -- -- O02485 649 1.4e-66 Uncharacterized protein ZK1073.1 OS=Caenorhabditis elegans GN=ZK1073.1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.27900 BP_3 2.48 0.67 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27901 BP_3 52.78 1.96 1591 91092778 XP_973837.1 342 2.3e-29 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.27903 BP_3 7980.10 55.48 7224 546685128 ERL94655.1 4086 0.0e+00 hypothetical protein D910_11930, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24298 2999 0.0e+00 DE-cadherin OS=Drosophila melanogaster GN=shg PE=1 SV=2 PF00028//PF01049//PF00008 Cadherin domain//Cadherin cytoplasmic region//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.27904 BP_3 33.09 0.57 3089 642938535 XP_008199831.1 1373 1.2e-148 PREDICTED: uncharacterized protein LOC103314771 [Tribolium castaneum] 642938534 XM_008201609.1 224 4.21587e-111 PREDICTED: Tribolium castaneum uncharacterized LOC103314771 (LOC103314771), mRNA -- -- -- -- -- -- -- -- PF13833//PF00036//PF13405//PF13499//PF13202 EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.27908 BP_3 296.94 1.53 9637 91086935 XP_972534.1 3774 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2369 5.1e-265 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13958//PF14719//PF00664//PF13304//PF01926//PF00437//PF00005//PF05209//PF03193//PF02724//PF00640//PF00931 Toxin ToxN, type III toxin-antitoxin system//Phosphotyrosine interaction domain (PTB/PID)//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein//ABC transporter//Septum formation inhibitor MinC, N-terminal domain//Protein of unknown function, DUF258//CDC45-like protein//Phosphotyrosine interaction domain (PTB/PID)//NB-ARC domain GO:0051252//GO:0009987//GO:0051302//GO:0055085//GO:0006270//GO:0006810 regulation of RNA metabolic process//cellular process//regulation of cell division//transmembrane transport//DNA replication initiation//transport GO:0000166//GO:0016887//GO:0042626//GO:0005524//GO:0003924//GO:0004521//GO:0005525//GO:0003723//GO:0043531//GO:0005515 nucleotide binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//endoribonuclease activity//GTP binding//RNA binding//ADP binding//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.27909 BP_3 73.77 1.36 2906 642927029 XP_008195110.1 1013 6.5e-107 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AY04 189 9.4e-13 Uncharacterized protein C2orf47 homolog, mitochondrial OS=Rattus norvegicus PE=2 SV=1 PF07961//PF00170//PF12884 MBA1-like protein//bZIP transcription factor//Transducer of regulated CREB activity, N terminus GO:0051289//GO:0032979//GO:0006355 protein homotetramerization//protein insertion into mitochondrial membrane from inner side//regulation of transcription, DNA-templated GO:0008140//GO:0043565//GO:0003700 cAMP response element binding protein binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005743//GO:0005667 mitochondrial inner membrane//transcription factor complex -- -- Cluster-8309.2791 BP_3 29.80 1.06 1644 321465971 EFX76969.1 1014 2.8e-107 hypothetical protein DAPPUDRAFT_321849 [Daphnia pulex] -- -- -- -- -- -- -- -- -- O02485 764 1.1e-79 Uncharacterized protein ZK1073.1 OS=Caenorhabditis elegans GN=ZK1073.1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.27910 BP_3 334.03 3.64 4712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27911 BP_3 297.97 3.26 4697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27912 BP_3 36.18 0.47 3976 642915135 XP_008190425.1 2842 0.0e+00 PREDICTED: importin-11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UI26 1945 3.1e-216 Importin-11 OS=Homo sapiens GN=IPO11 PE=1 SV=1 PF03810//PF02985 Importin-beta N-terminal domain//HEAT repeat GO:0006886 intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding -- -- KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) Cluster-8309.27913 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27915 BP_3 85.28 0.90 4865 642912121 XP_008200815.1 1300 5.7e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1R3 469 5.4e-45 StAR-related lipid transfer protein 7, mitochondrial OS=Mus musculus GN=Stard7 PE=2 SV=2 PF01134//PF01852//PF07664//PF00070//PF00899//PF01266//PF00965//PF01593//PF12831//PF01494//PF07992//PF09452 Glucose inhibited division protein A//START domain//Ferrous iron transport protein B C terminus//Pyridine nucleotide-disulphide oxidoreductase//ThiF family//FAD dependent oxidoreductase//Tissue inhibitor of metalloproteinase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//ESCRT-I subunit Mvb12 GO:0032509//GO:0015684//GO:0008033//GO:0055114 endosome transport via multivesicular body sorting pathway//ferrous iron transport//tRNA processing//oxidation-reduction process GO:0008191//GO:0071949//GO:0043130//GO:0008289//GO:0015093//GO:0016491//GO:0050660//GO:0008641 metalloendopeptidase inhibitor activity//FAD binding//ubiquitin binding//lipid binding//ferrous iron transmembrane transporter activity//oxidoreductase activity//flavin adenine dinucleotide binding//small protein activating enzyme activity GO:0016021//GO:0000813 integral component of membrane//ESCRT I complex -- -- Cluster-8309.27916 BP_3 52.89 1.11 2582 642912121 XP_008200815.1 1300 3.0e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6QHF9 414 6.8e-39 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01266//PF01134//PF00899//PF07664//PF00070//PF01494//PF07992//PF02740//PF01593//PF12831 FAD dependent oxidoreductase//Glucose inhibited division protein A//ThiF family//Ferrous iron transport protein B C terminus//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Colipase, C-terminal domain//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase GO:0016042//GO:0008033//GO:0015684//GO:0055114//GO:0007586 lipid catabolic process//tRNA processing//ferrous iron transport//oxidation-reduction process//digestion GO:0050660//GO:0008047//GO:0008641//GO:0071949//GO:0015093//GO:0016491 flavin adenine dinucleotide binding//enzyme activator activity//small protein activating enzyme activity//FAD binding//ferrous iron transmembrane transporter activity//oxidoreductase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.27917 BP_3 4.00 0.50 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27918 BP_3 1265.99 23.10 2933 91077792 XP_969461.1 2655 2.6e-297 PREDICTED: E3 UFM1-protein ligase 1 homolog [Tribolium castaneum]>gi|270001494|gb|EEZ97941.1| hypothetical protein TcasGA2_TC000331 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IG18 1620 1.1e-178 E3 UFM1-protein ligase 1 homolog OS=Aedes aegypti GN=AAEL003536 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2235 Uncharacterized conserved protein Cluster-8309.27921 BP_3 121.69 1.81 3529 642918312 XP_008191454.1 2864 0.0e+00 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.25084e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1917 4.9e-213 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.27924 BP_3 13.42 0.42 1831 91079957 XP_969398.1 796 5.9e-82 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27926 BP_3 238.47 0.94 12521 642937614 XP_008199122.1 11693 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 491 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 O95714 3271 0.0e+00 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2 PF07236//PF02898//PF00569//PF06701 Phytoreovirus S7 protein//Nitric oxide synthase, oxygenase domain//Zinc finger, ZZ type//Mib_herc2 GO:0055114//GO:0016567//GO:0006809 oxidation-reduction process//protein ubiquitination//nitric oxide biosynthetic process GO:0046872//GO:0008270//GO:0004842//GO:0004517 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//nitric-oxide synthase activity GO:0019012 virion KOG1426 FOG: RCC1 domain Cluster-8309.27927 BP_3 100.08 0.42 11821 642937614 XP_008199122.1 13158 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 640826247 XM_008072077.1 90 5.02929e-36 PREDICTED: Tarsius syrichta E3 ubiquitin-protein ligase HERC2 (LOC103274643), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 O95714 3962 0.0e+00 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2 PF02898//PF00569//PF07236//PF06701 Nitric oxide synthase, oxygenase domain//Zinc finger, ZZ type//Phytoreovirus S7 protein//Mib_herc2 GO:0055114//GO:0016567//GO:0006809 oxidation-reduction process//protein ubiquitination//nitric oxide biosynthetic process GO:0046872//GO:0008270//GO:0004842//GO:0004517 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//nitric-oxide synthase activity GO:0019012 virion KOG1426 FOG: RCC1 domain Cluster-8309.27929 BP_3 10.00 0.87 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15088 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial -- -- -- -- GO:0005747//GO:0005739 mitochondrial respiratory chain complex I//mitochondrion -- -- Cluster-8309.27930 BP_3 34.30 1.14 1745 642920133 XP_975457.2 643 3.1e-64 PREDICTED: NEDD4 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NV92 274 7.9e-23 NEDD4 family-interacting protein 2 OS=Homo sapiens GN=NDFIP2 PE=1 SV=2 PF10176//PF04479 Protein of unknown function (DUF2370)//RTA1 like protein GO:0006950//GO:0030001//GO:0007034 response to stress//metal ion transport//vacuolar transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27931 BP_3 873.73 48.95 1152 642920133 XP_975457.2 825 1.6e-85 PREDICTED: NEDD4 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91ZP6 287 1.6e-24 NEDD4 family-interacting protein 2 (Fragment) OS=Mus musculus GN=Ndfip2 PE=1 SV=2 PF10176 Protein of unknown function (DUF2370) GO:0030001//GO:0007034 metal ion transport//vacuolar transport -- -- -- -- -- -- Cluster-8309.27933 BP_3 91.50 3.81 1449 91087659 XP_973571.1 948 1.1e-99 PREDICTED: proteasome subunit beta type-6 [Tribolium castaneum]>gi|270009417|gb|EFA05865.1| hypothetical protein TcasGA2_TC008665 [Tribolium castaneum] -- -- -- -- -- K02738 PSMB6 20S proteasome subunit beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02738 Q3MHN0 713 8.2e-74 Proteasome subunit beta type-6 OS=Bos taurus GN=PSMB6 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005634//GO:0005839//GO:0005737 nucleus//proteasome core complex//cytoplasm KOG0174 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 Cluster-8309.27934 BP_3 740.93 33.27 1365 91087659 XP_973571.1 948 1.1e-99 PREDICTED: proteasome subunit beta type-6 [Tribolium castaneum]>gi|270009417|gb|EFA05865.1| hypothetical protein TcasGA2_TC008665 [Tribolium castaneum] -- -- -- -- -- K02738 PSMB6 20S proteasome subunit beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02738 Q3MHN0 713 7.7e-74 Proteasome subunit beta type-6 OS=Bos taurus GN=PSMB6 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839//GO:0005634//GO:0005737 proteasome core complex//nucleus//cytoplasm KOG0174 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 Cluster-8309.27936 BP_3 1.00 0.64 363 642914190 XP_008201582.1 181 2.4e-11 PREDICTED: uncharacterized protein LOC661670 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27939 BP_3 431.00 14.15 1760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2794 BP_3 5.00 0.58 707 270016095 EFA12543.1 404 6.5e-37 hypothetical protein TcasGA2_TC016068 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27940 BP_3 17.37 0.41 2346 642923214 XP_008193658.1 1153 3.1e-123 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K04360 NTRK2, TRKB neurotrophic tyrosine kinase receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04360 Q24488 546 3.1e-54 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF00069//PF07714//PF02294 Protein kinase domain//Protein tyrosine kinase//7kD DNA-binding domain GO:0051252//GO:0006468 regulation of RNA metabolic process//protein phosphorylation GO:0004521//GO:0004672//GO:0003677//GO:0005524 endoribonuclease activity//protein kinase activity//DNA binding//ATP binding -- -- -- -- Cluster-8309.27943 BP_3 74.00 3.99 1185 642937675 XP_008198897.1 227 3.7e-16 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC655743 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus -- -- Cluster-8309.27945 BP_3 125.67 5.67 1361 91087735 XP_974721.1 297 3.2e-24 PREDICTED: synaptosomal-associated protein 25 isoform X3 [Tribolium castaneum] 827536800 XM_012689330.1 106 7.22236e-46 PREDICTED: Bombyx mori synaptosomal-associated protein 25 (LOC101739206), transcript variant X1, mRNA K08508 SNAP23 synaptosomal-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K08508 P36975 253 1.7e-20 Synaptosomal-associated protein 25 OS=Drosophila melanogaster GN=Snap25 PE=2 SV=1 PF05739 SNARE domain -- -- GO:0005515 protein binding -- -- KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.27946 BP_3 184.28 2.51 3824 642924301 XP_008194238.1 2952 0.0e+00 PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924303|ref|XP_008194239.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924305|ref|XP_008194240.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K00111 glpA, glpD glycerol-3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00111 A6QLU1 2140 7.3e-239 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Bos taurus GN=GPD2 PE=2 SV=1 PF12831//PF13202//PF07992//PF00036//PF02976//PF01134//PF12632//PF13499//PF01266//PF13833//PF13405 FAD dependent oxidoreductase//EF hand//Pyridine nucleotide-disulphide oxidoreductase//EF hand//DNA mismatch repair enzyme MutH//Glucose inhibited division protein A//Mysoin-binding motif of peroxisomes//EF-hand domain pair//FAD dependent oxidoreductase//EF-hand domain pair//EF-hand domain GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0016491//GO:0004519//GO:0003677//GO:0005509//GO:0050660//GO:0017022 oxidoreductase activity//endonuclease activity//DNA binding//calcium ion binding//flavin adenine dinucleotide binding//myosin binding GO:0016459 myosin complex KOG0042 Glycerol-3-phosphate dehydrogenase Cluster-8309.27947 BP_3 293.14 9.05 1853 478261514 ENN80859.1 712 3.3e-72 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 P13582 486 2.2e-47 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.27948 BP_3 1234.00 45.39 1602 91085959 XP_971351.1 940 1.0e-98 PREDICTED: RNA-binding protein pno1 [Tribolium castaneum]>gi|270010173|gb|EFA06621.1| hypothetical protein TcasGA2_TC009539 [Tribolium castaneum] 754410228 XM_011276050.1 55 1.91403e-17 Wickerhamomyces ciferrii Pre-rRNA-processing protein partial mRNA K11884 PNO1, DIM2 RNA-binding protein PNO1 http://www.genome.jp/dbget-bin/www_bget?ko:K11884 Q29IG6 762 1.9e-79 RNA-binding protein pno1 OS=Drosophila pseudoobscura pseudoobscura GN=l(1)G0004 PE=3 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG3273 Predicted RNA-binding protein Pno1p interacting with Nob1p and involved in 26S proteasome assembly Cluster-8309.27949 BP_3 29.03 0.74 2191 642922855 XP_008200424.1 1554 9.1e-170 PREDICTED: mRNA cap guanine-N7 methyltransferase [Tribolium castaneum] -- -- -- -- -- K00565 RNMT mRNA (guanine-N7-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00565 Q9VJQ4 976 3.9e-104 mRNA cap guanine-N7 methyltransferase OS=Drosophila melanogaster GN=l(2)35Bd PE=1 SV=2 PF09807//PF08241 Elongation complex protein 6//Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity GO:0033588 Elongator holoenzyme complex KOG1975 mRNA cap methyltransferase Cluster-8309.27950 BP_3 637.00 18.00 1997 642922855 XP_008200424.1 1554 8.2e-170 PREDICTED: mRNA cap guanine-N7 methyltransferase [Tribolium castaneum] -- -- -- -- -- K00565 RNMT mRNA (guanine-N7-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00565 Q9VJQ4 976 3.6e-104 mRNA cap guanine-N7 methyltransferase OS=Drosophila melanogaster GN=l(2)35Bd PE=1 SV=2 PF09807//PF08241 Elongation complex protein 6//Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity GO:0033588 Elongator holoenzyme complex KOG1975 mRNA cap methyltransferase Cluster-8309.27952 BP_3 318.18 15.29 1295 91094189 XP_971060.1 879 1.0e-91 PREDICTED: G protein pathway suppressor 2 isoform X1 [Tribolium castaneum]>gi|270010855|gb|EFA07303.1| hypothetical protein TcasGA2_TC015893 [Tribolium castaneum] -- -- -- -- -- K15307 GPS2 G protein pathway suppressor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15307 Q13227 149 1.8e-08 G protein pathway suppressor 2 OS=Homo sapiens GN=GPS2 PE=1 SV=3 PF15048 Organic solute transporter subunit beta protein GO:0015721//GO:0006810 bile acid and bile salt transport//transport GO:0046982//GO:0005215 protein heterodimerization activity//transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.27953 BP_3 159.65 7.33 1342 91094189 XP_971060.1 879 1.0e-91 PREDICTED: G protein pathway suppressor 2 isoform X1 [Tribolium castaneum]>gi|270010855|gb|EFA07303.1| hypothetical protein TcasGA2_TC015893 [Tribolium castaneum] -- -- -- -- -- K15307 GPS2 G protein pathway suppressor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15307 Q13227 149 1.9e-08 G protein pathway suppressor 2 OS=Homo sapiens GN=GPS2 PE=1 SV=3 PF15048 Organic solute transporter subunit beta protein GO:0006810//GO:0015721 transport//bile acid and bile salt transport GO:0046982//GO:0005215 protein heterodimerization activity//transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.27958 BP_3 311.06 24.21 911 478256130 ENN76329.1 942 3.5e-99 hypothetical protein YQE_07292, partial [Dendroctonus ponderosae]>gi|546675872|gb|ERL86977.1| hypothetical protein D910_04380 [Dendroctonus ponderosae] -- -- -- -- -- K07556 ATPeAF2, ATPAF2, ATP12 ATP synthase mitochondrial F1 complex assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07556 Q1LZ96 580 1.4e-58 ATP synthase mitochondrial F1 complex assembly factor 2 OS=Bos taurus GN=ATPAF2 PE=2 SV=1 PF07542 ATP12 chaperone protein GO:0043461 proton-transporting ATP synthase complex assembly -- -- -- -- KOG3015 F1-ATP synthase assembly protein Cluster-8309.2796 BP_3 22.00 2.27 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27960 BP_3 355.31 15.61 1389 91081511 XP_974643.1 958 7.4e-101 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 P70280 704 8.6e-73 Vesicle-associated membrane protein 7 OS=Mus musculus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.27961 BP_3 120.77 1.60 3934 91077466 XP_968191.1 636 4.6e-63 PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|642914015|ref|XP_008201511.1| PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|270002138|gb|EEZ98585.1| hypothetical protein TcasGA2_TC001099 [Tribolium castaneum] -- -- -- -- -- K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 Q5EB97 167 4.5e-10 Zinc finger CCHC domain-containing protein 10 OS=Rattus norvegicus GN=Zcchc10 PE=2 SV=2 PF02190//PF09726//PF04889//PF00098 ATP-dependent protease La (LON) substrate-binding domain//Transmembrane protein//Cwf15/Cwc15 cell cycle control protein//Zinc knuckle GO:0000398//GO:0006510//GO:0006508 mRNA splicing, via spliceosome//obsolete ATP-dependent proteolysis//proteolysis GO:0003676//GO:0004176//GO:0008270 nucleic acid binding//ATP-dependent peptidase activity//zinc ion binding GO:0005681//GO:0016021 spliceosomal complex//integral component of membrane KOG3116 Predicted C3H1-type Zn-finger protein Cluster-8309.27963 BP_3 26.49 0.95 1640 283046732 NP_001164313.1 1426 4.7e-155 peroxidase precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 1.7e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.27966 BP_3 1431.72 24.45 3114 642917502 XP_008191229.1 1994 1.2e-220 PREDICTED: uncharacterized protein LOC657403 [Tribolium castaneum] 642917501 XM_008193007.1 460 0 PREDICTED: Tribolium castaneum uncharacterized LOC657403 (LOC657403), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27967 BP_3 291.00 29.20 772 91089671 XP_974390.1 493 3.4e-47 PREDICTED: protein lethal(2)essential for life [Tribolium castaneum]>gi|270012628|gb|EFA09076.1| hypothetical protein TcasGA2_TC006793 [Tribolium castaneum] 817189789 XM_012414812.1 41 5.46549e-10 PREDICTED: Orussus abietinus protein lethal(2)essential for life-like (LOC105694292), mRNA K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 280 7.0e-24 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.27968 BP_3 95.58 0.98 5013 270012482 EFA08930.1 2066 8.8e-229 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 992 1.3e-105 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.27970 BP_3 27.53 0.80 1957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02121 Phosphatidylinositol transfer protein GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.27971 BP_3 258.63 7.86 1878 751799211 XP_011209556.1 688 2.0e-69 PREDICTED: methyltransferase-like protein 23 [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q5U312 190 4.7e-13 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF16367//PF00076//PF06839//PF13606//PF00887//PF00023 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//GRF zinc finger//Ankyrin repeat//Acyl CoA binding protein//Ankyrin repeat -- -- GO:0005515//GO:0003676//GO:0008270//GO:0000062 protein binding//nucleic acid binding//zinc ion binding//fatty-acyl-CoA binding -- -- -- -- Cluster-8309.27974 BP_3 4.00 0.62 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27976 BP_3 62.27 3.40 1175 -- -- -- -- -- 462299627 APGK01051253.1 52 6.47851e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27977 BP_3 28.11 1.04 1590 642936948 XP_008198624.1 1463 2.3e-159 PREDICTED: transmembrane protein 39A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NV64 653 8.1e-67 Transmembrane protein 39A OS=Homo sapiens GN=TMEM39A PE=2 SV=1 PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- KOG3828 Uncharacterized conserved protein Cluster-8309.27978 BP_3 32.17 1.15 1642 642936948 XP_008198624.1 1226 7.3e-132 PREDICTED: transmembrane protein 39A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NV64 541 8.1e-54 Transmembrane protein 39A OS=Homo sapiens GN=TMEM39A PE=2 SV=1 PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- KOG3828 Uncharacterized conserved protein Cluster-8309.27980 BP_3 61.27 0.69 4552 727098876 AIY54294.1 1897 3.2e-209 actin 2 [Colaphellus bowringi] 605059338 KJ187399.1 270 1.67362e-136 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1829 1.0e-202 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186//PF00278 Vacuolar sorting 38 and autophagy-related subunit 14//Pyridoxal-dependent decarboxylase, C-terminal sheet domain GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.27981 BP_3 320.36 2.43 6649 478258659 ENN78709.1 2012 2.1e-222 hypothetical protein YQE_04881, partial [Dendroctonus ponderosae] 478512620 XM_004430515.1 38 2.27608e-07 PREDICTED: Ceratotherium simum simum death inducer-obliterator 1 (DIDO1), mRNA -- -- -- -- Q8BFT6 770 9.2e-80 JmjC domain-containing protein 4 OS=Mus musculus GN=Jmjd4 PE=2 SV=1 PF07500//PF00628//PF07533//PF06427 Transcription factor S-II (TFIIS), central domain//PHD-finger//BRK domain//UDP-glucose:Glycoprotein Glucosyltransferase GO:0006351//GO:0006486 transcription, DNA-templated//protein glycosylation GO:0016817//GO:0003980//GO:0005515 hydrolase activity, acting on acid anhydrides//UDP-glucose:glycoprotein glucosyltransferase activity//protein binding -- -- KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.27983 BP_3 144.14 1.97 3811 642933538 XP_008197461.1 1923 2.6e-212 PREDICTED: tyrosine-protein phosphatase non-receptor type 4 [Tribolium castaneum]>gi|270011334|gb|EFA07782.1| hypothetical protein TcasGA2_TC005339 [Tribolium castaneum] 817186761 XM_012432473.1 151 1.98406e-70 PREDICTED: Orussus abietinus tyrosine-protein phosphatase non-receptor type 4 (LOC105703795), transcript variant X5, mRNA K18037 PTPN4, MEG tyrosine-protein phosphatase non-receptor type 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18037 Q9WU22 988 2.8e-105 Tyrosine-protein phosphatase non-receptor type 4 OS=Mus musculus GN=Ptpn4 PE=1 SV=2 PF00102//PF05891//PF00782 Protein-tyrosine phosphatase//AdoMet dependent proline di-methyltransferase//Dual specificity phosphatase, catalytic domain GO:0035335//GO:0006480//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//N-terminal protein amino acid methylation//protein dephosphorylation//tyrosine metabolic process GO:0008168//GO:0004725//GO:0008138 methyltransferase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity GO:0005856 cytoskeleton KOG0792 Protein tyrosine phosphatase PTPMEG, contains FERM domain Cluster-8309.27987 BP_3 634.65 8.73 3796 189236660 XP_970787.2 998 4.7e-105 PREDICTED: ras-related protein Rab-30 [Tribolium castaneum] 755966246 XM_011307137.1 176 2.50266e-84 PREDICTED: Fopius arisanus ras-related protein Rab-30 (LOC105267941), mRNA K07917 RAB30 Ras-related protein Rab-30 http://www.genome.jp/dbget-bin/www_bget?ko:K07917 Q17QB7 701 5.3e-72 Ras-related protein Rab-30 OS=Bos taurus GN=RAB30 PE=2 SV=1 PF04670//PF00071//PF02367//PF03193//PF00176//PF00025//PF02421//PF00004//PF01926//PF08477//PF07728 Gtr1/RagA G protein conserved region//Ras family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//SNF2 family N-terminal domain//ADP-ribosylation factor family//Ferrous iron transport protein B//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily) GO:0002949//GO:0007264//GO:0015684 tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0016887//GO:0015093//GO:0005524//GO:0003924 GTP binding//ATPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0095 GTPase Rab30, small G protein superfamily Cluster-8309.27988 BP_3 42.35 0.57 3861 478257033 ENN77197.1 873 1.5e-90 hypothetical protein YQE_06335, partial [Dendroctonus ponderosae]>gi|546676062|gb|ERL87139.1| hypothetical protein D910_04539 [Dendroctonus ponderosae] 755966246 XM_011307137.1 166 9.22178e-79 PREDICTED: Fopius arisanus ras-related protein Rab-30 (LOC105267941), mRNA K07917 RAB30 Ras-related protein Rab-30 http://www.genome.jp/dbget-bin/www_bget?ko:K07917 Q923S9 682 8.5e-70 Ras-related protein Rab-30 OS=Mus musculus GN=Rab30 PE=2 SV=1 PF08477//PF07728//PF01926//PF00004//PF02421//PF00025//PF00176//PF03193//PF02367//PF00071//PF04670 Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Ferrous iron transport protein B//ADP-ribosylation factor family//SNF2 family N-terminal domain//Protein of unknown function, DUF258//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Ras family//Gtr1/RagA G protein conserved region GO:0015684//GO:0007264//GO:0002949 ferrous iron transport//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification GO:0016887//GO:0005525//GO:0003924//GO:0015093//GO:0005524 ATPase activity//GTP binding//GTPase activity//ferrous iron transmembrane transporter activity//ATP binding GO:0016021 integral component of membrane KOG0095 GTPase Rab30, small G protein superfamily Cluster-8309.27989 BP_3 116.27 1.03 5725 164698398 NP_001106936.1 2363 3.7e-263 timeless isoform B [Tribolium castaneum]>gi|140270876|gb|ABO86541.1| TIMELESS isoform B [Tribolium castaneum] -- -- -- -- -- K12074 TIM timeless http://www.genome.jp/dbget-bin/www_bget?ko:K12074 P49021 1629 2.0e-179 Protein timeless OS=Drosophila melanogaster GN=tim PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27990 BP_3 19.61 0.69 1658 255522797 NP_001157311.1 324 2.9e-27 longitudinals lacking isoform 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 142 1.5e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF05191//PF01780//PF07649//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Adenylate kinase, active site lid//Ribosomal L37ae protein family//C1-like domain//BED zinc finger GO:0042254//GO:0055114//GO:0046034//GO:0006144//GO:0006412 ribosome biogenesis//oxidation-reduction process//ATP metabolic process//purine nucleobase metabolic process//translation GO:0003735//GO:0004017//GO:0046872//GO:0047134//GO:0003677 structural constituent of ribosome//adenylate kinase activity//metal ion binding//protein-disulfide reductase activity//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.27991 BP_3 504.87 10.84 2536 642929814 XP_008195987.1 1125 5.8e-120 PREDICTED: E3 ubiquitin-protein ligase Topors-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10631 TOPORS E3 ubiquitin-protein ligase Topors http://www.genome.jp/dbget-bin/www_bget?ko:K10631 Q9V8P9 487 2.3e-47 E3 ubiquitin-protein ligase Topors OS=Drosophila melanogaster GN=Topors PE=1 SV=1 PF01480//PF13639//PF16685//PF12678//PF14634//PF12861//PF00097 PWI domain//Ring finger domain//zinc RING finger of MSL2//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger) GO:0006397//GO:0016567 mRNA processing//protein ubiquitination GO:0008270//GO:0046872//GO:0061630//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG4430 Topoisomerase I-binding arginine-serine-rich protein Cluster-8309.27992 BP_3 605.71 11.72 2783 642936148 XP_008198317.1 2326 3.5e-259 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Tribolium castaneum] 571506739 XM_397111.4 230 1.75242e-114 PREDICTED: Apis mellifera f-box/LRR-repeat protein 2-like (LOC413670), transcript variant X1, mRNA -- -- -- -- Q8BH16 205 1.3e-14 F-box/LRR-repeat protein 2 OS=Mus musculus GN=Fbxl2 PE=1 SV=1 PF00646//PF15966//PF13639//PF12937 F-box domain//F-box//Ring finger domain//F-box-like -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.27994 BP_3 178.34 1.12 7955 642926648 XP_970736.2 988 1.4e-103 PREDICTED: elongator complex protein 1 [Tribolium castaneum] 642911902 XM_008200793.1 91 9.39577e-37 PREDICTED: Tribolium castaneum heat shock factor protein-like (LOC103314511), transcript variant X4, mRNA K09418 HSFN heat shock transcription factor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09418 Q9VGK7 484 1.6e-46 Putative elongator complex protein 1 OS=Drosophila melanogaster GN=Elp1 PE=1 SV=2 PF00447//PF00637 HSF-type DNA-binding//Region in Clathrin and VPS GO:0006355//GO:0006886//GO:0016192 regulation of transcription, DNA-templated//intracellular protein transport//vesicle-mediated transport GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0627 Heat shock transcription factor Cluster-8309.27999 BP_3 318.00 4.59 3632 642928127 XP_970826.2 344 3.0e-29 PREDICTED: uncharacterized protein LOC659425 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03598 CO dehydrogenase/acetyl-CoA synthase complex beta subunit GO:0006084//GO:0015947 acetyl-CoA metabolic process//methane metabolic process GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity -- -- -- -- Cluster-8309.28 BP_3 8.86 0.39 1399 341904444 EGT60277.1 717 6.6e-73 CBN-SODH-1 protein [Caenorhabditis brenneri] 768311756 CP010984.1 1215 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence K13953 adhP alcohol dehydrogenase, propanol-preferring http://www.genome.jp/dbget-bin/www_bget?ko:K13953 Q9P6C8 1464 6.5e-161 Alcohol dehydrogenase 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=adh-1 PE=3 SV=1 PF00107//PF00899//PF02826//PF08240//PF15096 Zinc-binding dehydrogenase//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Alcohol dehydrogenase GroES-like domain//G6B family GO:0055114 oxidation-reduction process GO:0051287//GO:0008641 NAD binding//small protein activating enzyme activity GO:0016021 integral component of membrane KOG0023 Alcohol dehydrogenase, class V Cluster-8309.280 BP_3 7.00 0.67 793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28000 BP_3 152.00 7.50 1268 91079036 XP_974974.1 1426 3.6e-155 PREDICTED: mediator of RNA polymerase II transcription subunit 27 [Tribolium castaneum]>gi|270003666|gb|EFA00114.1| hypothetical protein TcasGA2_TC002930 [Tribolium castaneum] -- -- -- -- -- K15170 MED27 mediator of RNA polymerase II transcription subunit 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15170 Q7QCJ9 854 3.2e-90 Mediator of RNA polymerase II transcription subunit 27 OS=Anopheles gambiae GN=MED27 PE=3 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28002 BP_3 6.00 1.64 468 260815961 XP_002602741.1 139 2.3e-06 hypothetical protein BRAFLDRAFT_233840 [Branchiostoma floridae]>gi|229288052|gb|EEN58753.1| hypothetical protein BRAFLDRAFT_233840, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04988//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.28003 BP_3 81.73 3.04 1587 546673009 ERL84695.1 199 8.7e-13 hypothetical protein D910_02121 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- C3XVM1 144 8.5e-08 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Branchiostoma floridae GN=BRAFLDRAFT_270748 PE=3 SV=1 PF02686 Glu-tRNAGln amidotransferase C subunit GO:0006450 regulation of translational fidelity -- -- -- -- -- -- Cluster-8309.28006 BP_3 70.26 0.76 4738 642931654 XP_008196673.1 2461 1.3e-274 PREDICTED: rap1 GTPase-activating protein 1 isoform X1 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.55181e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 4.2e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF02188//PF07836//PF02145//PF13851 GoLoco motif//DmpG-like communication domain//Rap/ran-GAP//Growth-arrest specific micro-tubule binding GO:0048870//GO:0051056//GO:0019439 cell motility//regulation of small GTPase mediated signal transduction//aromatic compound catabolic process GO:0016833//GO:0005096//GO:0030695 oxo-acid-lyase activity//GTPase activator activity//GTPase regulator activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.28008 BP_3 18.00 2.59 627 478254316 ENN74570.1 289 1.3e-23 hypothetical protein YQE_08892, partial [Dendroctonus ponderosae]>gi|546674045|gb|ERL85533.1| hypothetical protein D910_02952 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2801 BP_3 171.56 2.94 3105 270004597 EFA01045.1 342 4.4e-29 hypothetical protein TcasGA2_TC003961 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28010 BP_3 114.00 4.36 1551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28013 BP_3 437.57 3.60 6152 642936704 XP_008198546.1 1663 5.8e-182 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P07207 158 7.9e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF13895//PF02793//PF00008 Immunoglobulin domain//Hormone receptor domain//EGF-like domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016020 membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.28014 BP_3 24.00 1.48 1072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02118 Srg family chemoreceptor GO:0007165//GO:0007606 signal transduction//sensory perception of chemical stimulus GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.28015 BP_3 48.14 0.42 5862 642934494 XP_008197688.1 4624 0.0e+00 PREDICTED: proteasome-associated protein ECM29 homolog [Tribolium castaneum] -- -- -- -- -- K11886 ECM29 proteasome component ECM29 http://www.genome.jp/dbget-bin/www_bget?ko:K11886 Q5VYK3 2160 5.4e-241 Proteasome-associated protein ECM29 homolog OS=Homo sapiens GN=ECM29 PE=1 SV=2 PF05184//PF02985 Saposin-like type B, region 1//HEAT repeat GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG0915 Uncharacterized conserved protein Cluster-8309.28016 BP_3 461.79 10.55 2401 642916627 XP_008191963.1 1621 1.7e-177 PREDICTED: GPI mannosyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K05284 PIGM phosphatidylinositol glycan, class M http://www.genome.jp/dbget-bin/www_bget?ko:K05284 Q7S4Z3 538 2.6e-53 GPI mannosyltransferase 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gim-1 PE=3 SV=1 PF16622//PF05051//PF06728//PF05007 zinc-finger C2H2-type//Cytochrome C oxidase copper chaperone (COX17)//GPI transamidase subunit PIG-U//Mannosyltransferase (PIG-M) GO:0006825//GO:0006506 copper ion transport//GPI anchor biosynthetic process GO:0005507//GO:0016531//GO:0016758//GO:0046872 copper ion binding//copper chaperone activity//transferase activity, transferring hexosyl groups//metal ion binding GO:0016021//GO:0005758 integral component of membrane//mitochondrial intermembrane space KOG3893 Mannosyltransferase Cluster-8309.28017 BP_3 134.21 3.19 2317 642916627 XP_008191963.1 1621 1.6e-177 PREDICTED: GPI mannosyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K05284 PIGM phosphatidylinositol glycan, class M http://www.genome.jp/dbget-bin/www_bget?ko:K05284 Q7S4Z3 538 2.6e-53 GPI mannosyltransferase 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gim-1 PE=3 SV=1 PF06728//PF05051//PF16622//PF05007 GPI transamidase subunit PIG-U//Cytochrome C oxidase copper chaperone (COX17)//zinc-finger C2H2-type//Mannosyltransferase (PIG-M) GO:0006825//GO:0006506 copper ion transport//GPI anchor biosynthetic process GO:0005507//GO:0016531//GO:0016758//GO:0046872 copper ion binding//copper chaperone activity//transferase activity, transferring hexosyl groups//metal ion binding GO:0016021//GO:0005758 integral component of membrane//mitochondrial intermembrane space KOG3893 Mannosyltransferase Cluster-8309.28019 BP_3 1197.55 19.24 3292 270008994 EFA05442.1 170 4.1e-09 hypothetical protein TcasGA2_TC015621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF08038 Ligand-gated ion channel//TOM7 family GO:0007165//GO:0007268//GO:0030150//GO:0006811 signal transduction//synaptic transmission//protein import into mitochondrial matrix//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016020//GO:0005742 membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.28020 BP_3 310.00 3.48 4580 189238821 XP_968538.2 715 3.7e-72 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|642927448|ref|XP_008195277.1| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|270010156|gb|EFA06604.1| hypothetical protein TcasGA2_TC009519 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 360 2.2e-32 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF13184//PF13014//PF00013//PF07650 NusA-like KH domain//KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.28021 BP_3 50.03 1.82 1617 546678918 ERL89456.1 328 9.7e-28 hypothetical protein D910_06823 [Dendroctonus ponderosae] 462304277 APGK01049550.1 97 8.6779e-41 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q7KQZ4 197 6.2e-14 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.28022 BP_3 171.00 9.41 1168 642929008 XP_008195652.1 996 2.4e-105 PREDICTED: mediator of RNA polymerase II transcription subunit 8 [Tribolium castaneum]>gi|270010446|gb|EFA06894.1| hypothetical protein TcasGA2_TC009839 [Tribolium castaneum] -- -- -- -- -- K15129 MED8 mediator of RNA polymerase II transcription subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K15129 Q16RR7 652 7.8e-67 Mediator of RNA polymerase II transcription subunit 8 OS=Aedes aegypti GN=MED8 PE=3 SV=1 PF10232//PF16969 Mediator of RNA polymerase II transcription complex subunit 8//RNA-binding signal recognition particle 68 GO:0006614//GO:0006357 SRP-dependent cotranslational protein targeting to membrane//regulation of transcription from RNA polymerase II promoter GO:0030942//GO:0001104//GO:0008312//GO:0005047 endoplasmic reticulum signal peptide binding//RNA polymerase II transcription cofactor activity//7S RNA binding//signal recognition particle binding GO:0016592//GO:0005786 mediator complex//signal recognition particle, endoplasmic reticulum targeting KOG3583 Uncharacterized conserved protein Cluster-8309.28023 BP_3 23.56 1.75 942 91085093 XP_967751.1 409 2.3e-37 PREDICTED: uridine diphosphate glucose pyrophosphatase [Tribolium castaneum]>gi|270008500|gb|EFA04948.1| hypothetical protein TcasGA2_TC015015 [Tribolium castaneum] -- -- -- -- -- K08077 NUDT14 UDP-sugar diphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K08077 Q05B60 139 1.9e-07 Uridine diphosphate glucose pyrophosphatase OS=Bos taurus GN=NUDT14 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4432 Uncharacterized NUDIX family hydrolase Cluster-8309.28026 BP_3 11.50 0.31 2091 642921374 XP_008192840.1 1115 6.9e-119 PREDICTED: translation initiation factor eIF-2B subunit epsilon isoform X2 [Tribolium castaneum] -- -- -- -- -- K03240 EIF2B5 translation initiation factor eIF-2B subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K03240 P47823 579 4.1e-58 Translation initiation factor eIF-2B subunit epsilon OS=Oryctolagus cuniculus GN=EIF2B5 PE=1 SV=1 PF00483//PF07959//PF02020 Nucleotidyl transferase//L-fucokinase//eIF4-gamma/eIF5/eIF2-epsilon GO:0009058 biosynthetic process GO:0005515//GO:0016779//GO:0016772 protein binding//nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6) Cluster-8309.28027 BP_3 23.00 2.62 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28029 BP_3 120.17 3.67 1870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07726 ATPase family associated with various cellular activities (AAA) -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- -- -- Cluster-8309.28030 BP_3 90.72 1.93 2563 478249755 ENN70263.1 495 6.7e-47 hypothetical protein YQE_13046, partial [Dendroctonus ponderosae] -- -- -- -- -- K06695 PSMC3IP 26S proteasome regulatory subunit, ATPase 3, interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K06695 Q63ZL2 310 7.7e-27 Homologous-pairing protein 2 homolog OS=Xenopus laevis GN=psmc3ip PE=2 SV=1 PF03647//PF03965//PF06156//PF08702//PF02601//PF10186 Transmembrane proteins 14C//Penicillinase repressor//Protein of unknown function (DUF972)//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006308//GO:0010508//GO:0030168//GO:0006260//GO:0045892//GO:0051258//GO:0007165 DNA catabolic process//positive regulation of autophagy//platelet activation//DNA replication//negative regulation of transcription, DNA-templated//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0008855//GO:0003677 receptor binding//protein binding, bridging//exodeoxyribonuclease VII activity//DNA binding GO:0005577//GO:0016020//GO:0009318 fibrinogen complex//membrane//exodeoxyribonuclease VII complex KOG4603 TBP-1 interacting protein Cluster-8309.28031 BP_3 618.00 20.77 1726 478250897 ENN71383.1 1324 3.3e-143 hypothetical protein YQE_11930, partial [Dendroctonus ponderosae]>gi|546671861|gb|ERL83988.1| hypothetical protein D910_01304 [Dendroctonus ponderosae]>gi|546671866|gb|ERL83991.1| hypothetical protein D910_01307 [Dendroctonus ponderosae]>gi|546678247|gb|ERL88919.1| hypothetical protein D910_06297 [Dendroctonus ponderosae] 751451367 XM_011181705.1 63 7.37645e-22 PREDICTED: Bactrocera cucurbitae partitioning defective protein 6 (LOC105210628), mRNA K06093 PARD6 partitioning defective protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06093 Q9JK83 737 1.6e-76 Partitioning defective 6 homolog beta OS=Mus musculus GN=Pard6b PE=1 SV=2 PF00595//PF13180//PF00564 PDZ domain (Also known as DHR or GLGF)//PDZ domain//PB1 domain -- -- GO:0005515 protein binding -- -- KOG3606 Cell polarity protein PAR6 Cluster-8309.28033 BP_3 40.39 0.44 4758 642931932 XP_973544.3 2688 6.3e-301 PREDICTED: structural maintenance of chromosomes protein 6 [Tribolium castaneum]>gi|270012741|gb|EFA09189.1| structural maintenance of chromosomes 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9I7 928 3.1e-98 Structural maintenance of chromosomes protein 6 OS=Xenopus laevis GN=smc6 PE=2 SV=1 PF13851//PF04632//PF04336//PF01146//PF00038//PF08702//PF03193//PF00005//PF16716//PF04108//PF08925//PF04111//PF13304//PF00430//PF01580//PF06160//PF10473 Growth-arrest specific micro-tubule binding//Fusaric acid resistance protein family//Protein of unknown function, DUF479//Caveolin//Intermediate filament protein//Fibrinogen alpha/beta chain family//Protein of unknown function, DUF258//ABC transporter//Bone marrow stromal antigen 2//Autophagy protein Apg17//Domain of Unknown Function (DUF1907)//Autophagy protein Apg6//AAA domain, putative AbiEii toxin, Type IV TA system//ATP synthase B/B' CF(0)//FtsK/SpoIIIE family//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0048870//GO:0000921//GO:0006633//GO:0030168//GO:0015992//GO:0051607//GO:0015986//GO:0070836//GO:0006810//GO:0051258//GO:0006914//GO:0015940//GO:0007165 cell motility//septin ring assembly//fatty acid biosynthetic process//platelet activation//proton transport//defense response to virus//ATP synthesis coupled proton transport//caveola assembly//transport//protein polymerization//autophagy//pantothenate biosynthetic process//signal transduction GO:0030674//GO:0003924//GO:0008134//GO:0045502//GO:0005524//GO:0005102//GO:0016887//GO:0003677//GO:0042803//GO:0005525//GO:0005198//GO:0008770//GO:0015078//GO:0000166 protein binding, bridging//GTPase activity//transcription factor binding//dynein binding//ATP binding//receptor binding//ATPase activity//DNA binding//protein homodimerization activity//GTP binding//structural molecule activity//[acyl-carrier-protein] phosphodiesterase activity//hydrogen ion transmembrane transporter activity//nucleotide binding GO:0005667//GO:0030286//GO:0005882//GO:0005577//GO:0005886//GO:0005634//GO:0005940//GO:0031514//GO:0016021//GO:0045263 transcription factor complex//dynein complex//intermediate filament//fibrinogen complex//plasma membrane//nucleus//septin ring//motile cilium//integral component of membrane//proton-transporting ATP synthase complex, coupling factor F(o) KOG0250 DNA repair protein RAD18 (SMC family protein) Cluster-8309.28034 BP_3 66.30 0.83 4147 642910771 XP_008193403.1 2110 5.8e-234 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.1e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF10297//PF00620 Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.28035 BP_3 612.05 8.20 3889 642910771 XP_008193403.1 2225 2.5e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 9.9e-58 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00150//PF10297//PF00620 Cellulase (glycosyl hydrolase family 5)//Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0007165//GO:0006355//GO:0005975 signal transduction//regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0003677//GO:0004553 DNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.28036 BP_3 27.78 0.38 3806 642910771 XP_008193403.1 2225 2.5e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 9.7e-58 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF10297//PF00620 Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.28037 BP_3 39.21 0.50 4074 642910771 XP_008193403.1 2225 2.6e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.0e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00150//PF10297//PF00620 Cellulase (glycosyl hydrolase family 5)//Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0006355//GO:0007165//GO:0005975 regulation of transcription, DNA-templated//signal transduction//carbohydrate metabolic process GO:0004553//GO:0003677 hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.28038 BP_3 647.00 53.93 870 91087931 XP_971703.1 683 3.6e-69 PREDICTED: suppressor of G2 allele of SKP1 homolog [Tribolium castaneum]>gi|270012029|gb|EFA08477.1| hypothetical protein TcasGA2_TC006127 [Tribolium castaneum] -- -- -- -- -- K12795 SUGT1, SGT1 suppressor of G2 allele of SKP1 http://www.genome.jp/dbget-bin/www_bget?ko:K12795 B0BN85 468 1.3e-45 Protein SGT1 homolog OS=Rattus norvegicus GN=Sugt1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1309 Suppressor of G2 allele of skp1 Cluster-8309.28040 BP_3 1487.40 37.30 2214 478251133 ENN71609.1 2456 2.3e-274 hypothetical protein YQE_11708, partial [Dendroctonus ponderosae]>gi|546680326|gb|ERL90612.1| hypothetical protein D910_07959 [Dendroctonus ponderosae] 769832105 XM_011642084.1 121 5.44426e-54 PREDICTED: Pogonomyrmex barbatus SUMO-activating enzyme subunit 2 (LOC105429240), mRNA K10685 UBLE1B, SAE2, UBA2 ubiquitin-like 1-activating enzyme E1 B http://www.genome.jp/dbget-bin/www_bget?ko:K10685 Q28GH3 1625 2.2e-179 SUMO-activating enzyme subunit 2 OS=Xenopus tropicalis GN=uba2 PE=2 SV=1 PF13241//PF03435//PF07818//PF00899 Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//HCNGP-like protein//ThiF family GO:0055114//GO:0006779//GO:0019354//GO:0006355 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//regulation of transcription, DNA-templated GO:0016491//GO:0008641//GO:0043115 oxidoreductase activity//small protein activating enzyme activity//precorrin-2 dehydrogenase activity -- -- KOG2013 SMT3/SUMO-activating complex, catalytic component UBA2 Cluster-8309.28044 BP_3 429.62 51.22 696 642912103 XP_008200806.1 754 1.7e-77 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X2 [Tribolium castaneum] 268574973 XM_002642420.1 89 1.01713e-36 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 600 5.0e-61 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF16326//PF04111//PF03938//PF01517//PF00769//PF01496 ABC transporter C-terminal domain//Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Hepatitis delta virus delta antigen//Ezrin/radixin/moesin family//V-type ATPase 116kDa subunit family GO:0015992//GO:0015991//GO:0006914 proton transport//ATP hydrolysis coupled proton transport//autophagy GO:0015078//GO:0051082//GO:0003677//GO:0003723//GO:0008092 hydrogen ion transmembrane transporter activity//unfolded protein binding//DNA binding//RNA binding//cytoskeletal protein binding GO:0005737//GO:0033179//GO:0042025//GO:0019898 cytoplasm//proton-transporting V-type ATPase, V0 domain//host cell nucleus//extrinsic component of membrane KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.28045 BP_3 417.29 6.01 3641 91089205 XP_966919.1 864 1.5e-89 PREDICTED: SPRY domain-containing SOCS box protein 3 [Tribolium castaneum]>gi|270012469|gb|EFA08917.1| hypothetical protein TcasGA2_TC006623 [Tribolium castaneum] -- -- -- -- -- K10345 SPSB3, SSB3 SPRY domain-containing SOCS box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10345 Q6PJ21 421 1.5e-39 SPRY domain-containing SOCS box protein 3 OS=Homo sapiens GN=SPSB3 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28046 BP_3 65.02 1.03 3339 642933817 XP_008197388.1 569 2.3e-55 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00288//PF03325 GHMP kinases N terminal domain//Herpesvirus polymerase accessory protein GO:0006260//GO:0019079 DNA replication//viral genome replication GO:0030337//GO:0005524 DNA polymerase processivity factor activity//ATP binding GO:0042575 DNA polymerase complex KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.28052 BP_3 18.19 0.53 1942 642919171 XP_967331.2 613 1.0e-60 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q5RFL4 454 1.2e-43 Zinc finger FYVE domain-containing protein 1 OS=Pongo abelii GN=ZFYVE1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.28053 BP_3 17.39 0.45 2146 86515330 NP_001034490.1 285 1.2e-22 pangolin [Tribolium castaneum]>gi|55832420|gb|AAV66724.1| pangolin [Tribolium castaneum] 55832417 AY800246.1 158 1.42555e-74 Tribolium castaneum pangolin gene, partial cds K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 Q9NQB0 206 7.4e-15 Transcription factor 7-like 2 OS=Homo sapiens GN=TCF7L2 PE=1 SV=2 -- -- GO:0016055 Wnt signaling pathway -- -- -- -- KOG3248 Transcription factor TCF-4 Cluster-8309.28056 BP_3 180.97 2.63 3603 91091508 XP_969167.1 1943 1.2e-214 PREDICTED: protein LMBR1L isoform X2 [Tribolium castaneum]>gi|270000933|gb|EEZ97380.1| hypothetical protein TcasGA2_TC011205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 905 1.1e-95 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.28057 BP_3 578.72 8.36 3629 91091508 XP_969167.1 1943 1.2e-214 PREDICTED: protein LMBR1L isoform X2 [Tribolium castaneum]>gi|270000933|gb|EEZ97380.1| hypothetical protein TcasGA2_TC011205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 905 1.1e-95 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.28058 BP_3 90.94 2.25 2238 642936854 XP_008197915.1 1215 1.9e-130 PREDICTED: protein LMBR1L isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 579 4.3e-58 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.28059 BP_3 146.05 1.86 4067 546676181 ERL87248.1 2281 8.4e-254 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9J0 409 4.1e-38 Mycosubtilin synthase subunit B OS=Bacillus subtilis GN=mycB PE=3 SV=1 PF00501//PF02733 AMP-binding enzyme//Dak1 domain GO:0008152//GO:0006071//GO:0046486 metabolic process//glycerol metabolic process//glycerolipid metabolic process GO:0003824//GO:0004371 catalytic activity//glycerone kinase activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.28063 BP_3 2119.00 183.28 849 546685100 ERL94627.1 290 1.3e-23 hypothetical protein D910_11902 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28064 BP_3 467.34 23.53 1249 270006897 EFA03345.1 533 1.3e-51 hypothetical protein TcasGA2_TC013325 [Tribolium castaneum] -- -- -- -- -- K18732 SARNP, CIP29, THO1 SAP domain-containing ribonucleoprotein http://www.genome.jp/dbget-bin/www_bget?ko:K18732 Q498U4 223 4.6e-17 SAP domain-containing ribonucleoprotein OS=Rattus norvegicus GN=Sarnp PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4259 Putative nucleic acid-binding protein Hcc-1/proliferation associated cytokine-inducible protein, contains SAP domain Cluster-8309.28066 BP_3 395.25 11.20 1992 642915192 XP_008190512.1 1457 1.5e-158 PREDICTED: protein phosphatase 1 regulatory subunit 12B-like isoform X2 [Tribolium castaneum]>gi|270003919|gb|EFA00367.1| hypothetical protein TcasGA2_TC003209 [Tribolium castaneum] 242023035 XM_002431897.1 52 1.11214e-15 Pediculus humanus corporis protein phosphatase 1 regulatory subunit 12B, putative, mRNA K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q90623 954 1.3e-101 Protein phosphatase 1 regulatory subunit 12A OS=Gallus gallus GN=PPP1R12A PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.28068 BP_3 5.81 0.47 884 546685993 ERL95399.1 223 7.9e-16 hypothetical protein D910_12663 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28069 BP_3 19.83 1.77 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2807 BP_3 1785.00 50.42 1998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01114 Colipase, N-terminal domain GO:0007586//GO:0016042 digestion//lipid catabolic process GO:0008047 enzyme activator activity GO:0005576 extracellular region -- -- Cluster-8309.28070 BP_3 99.98 3.26 1771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28071 BP_3 100.36 1.33 3931 546676985 ERL87909.1 599 8.9e-59 hypothetical protein D910_05297 [Dendroctonus ponderosae] -- -- -- -- -- K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 O61374 367 2.9e-33 Sex-lethal homolog OS=Ceratitis capitata GN=SXL PE=2 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.2808 BP_3 29.63 0.70 2320 642920562 XP_001816430.2 1349 5.7e-146 PREDICTED: uncharacterized protein LOC100141961 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 441 4.5e-42 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF01738//PF01764//PF04083 Dienelactone hydrolase family//Lipase (class 3)//Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.28083 BP_3 91.59 0.69 6645 642928921 XP_008195617.1 7734 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] 642928920 XM_008197395.1 1208 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 4429 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF11744//PF00443//PF05395//PF01080//PF02724//PF02985 Aluminium activated malate transporter//Ubiquitin carboxyl-terminal hydrolase//Protein phosphatase inhibitor 1/DARPP-32//Presenilin//CDC45-like protein//HEAT repeat GO:0016579//GO:0015743//GO:0006270//GO:0007165 protein deubiquitination//malate transport//DNA replication initiation//signal transduction GO:0005515//GO:0004864//GO:0036459//GO:0004190 protein binding//protein phosphatase inhibitor activity//ubiquitinyl hydrolase activity//aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28084 BP_3 29.39 0.38 3987 642928921 XP_008195617.1 2875 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 1119 1.9e-120 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.28087 BP_3 152.79 2.00 3976 642928921 XP_008195617.1 5039 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 1091 3.3e-117 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.28089 BP_3 50.06 0.41 6224 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 1.22045e-39 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 2.7e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF10417//PF03099//PF01496 C-terminal domain of 1-Cys peroxiredoxin//Biotin/lipoate A/B protein ligase family//V-type ATPase 116kDa subunit family GO:0006464//GO:0055114//GO:0015992//GO:0015991 cellular protein modification process//oxidation-reduction process//proton transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0051920 hydrogen ion transmembrane transporter activity//peroxiredoxin activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.2809 BP_3 515.99 18.16 1661 642920562 XP_001816430.2 1521 4.6e-166 PREDICTED: uncharacterized protein LOC100141961 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 475 3.7e-46 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083//PF01764//PF02129//PF01738 Partial alpha/beta-hydrolase lipase region//Lipase (class 3)//X-Pro dipeptidyl-peptidase (S15 family)//Dienelactone hydrolase family GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.28091 BP_3 58.00 1.94 1734 478257106 ENN77269.1 374 4.8e-33 hypothetical protein YQE_06097, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28092 BP_3 1058.57 22.81 2529 642923214 XP_008193658.1 1853 2.2e-204 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K04360 NTRK2, TRKB neurotrophic tyrosine kinase receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04360 Q24488 711 2.4e-73 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.28093 BP_3 61.93 3.94 1050 478256643 ENN76825.1 205 1.2e-13 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N3L3 145 4.3e-08 Beta-taxilin OS=Homo sapiens GN=TXLNB PE=1 SV=3 PF09728//PF00548 Myosin-like coiled-coil protein//3C cysteine protease (picornain 3C) GO:0006508 proteolysis GO:0019905//GO:0004197 syntaxin binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.28095 BP_3 741.78 22.41 1887 646708450 KDR14762.1 1095 1.3e-116 60S acidic ribosomal protein P0 [Zootermopsis nevadensis] 262401274 FJ774819.1 384 0 Scylla paramamosain acidic p0 ribosomal protein mRNA, partial cds K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 P47826 1060 6.1e-114 60S acidic ribosomal protein P0 OS=Gallus gallus GN=RPLP0 PE=2 SV=1 PF00637//PF09507//PF00466//PF02932//PF06459//PF02724 Region in Clathrin and VPS//DNA polymerase subunit Cdc27//Ribosomal protein L10//Neurotransmitter-gated ion-channel transmembrane region//Ryanodine Receptor TM 4-6//CDC45-like protein GO:0042254//GO:0006811//GO:0006874//GO:0006260//GO:0006886//GO:0006270//GO:0016192//GO:0006816 ribosome biogenesis//ion transport//cellular calcium ion homeostasis//DNA replication//intracellular protein transport//DNA replication initiation//vesicle-mediated transport//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016020//GO:0005634//GO:0016021 intracellular//membrane//nucleus//integral component of membrane KOG0815 60S acidic ribosomal protein P0 Cluster-8309.28096 BP_3 18.28 3.86 520 478269658 ENN83378.1 269 2.2e-21 hypothetical protein YQE_00263, partial [Dendroctonus ponderosae] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 134 4.0e-07 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862 DDHD domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.28098 BP_3 40.19 0.80 2710 642934951 XP_008195932.1 1438 3.2e-156 PREDICTED: protein MTO1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03495 gidA, mnmG, MTO1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K03495 Q4R4P6 1045 4.8e-112 Protein MTO1 homolog, mitochondrial OS=Macaca fascicularis GN=MTO1 PE=2 SV=1 PF01059//PF01134//PF12831//PF00070//PF01494//PF05834//PF07992 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Glucose inhibited division protein A//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0008033//GO:0016117//GO:0006120 oxidation-reduction process//tRNA processing//carotenoid biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0050660//GO:0016491//GO:0016705//GO:0071949 flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding -- -- KOG2311 NAD/FAD-utilizing protein possibly involved in translation Cluster-8309.281 BP_3 2.00 0.47 497 83628250 ABC26005.1 455 5.6e-43 arthrodial cuticle protein AMP16.3 [Callinectes sapidus] 83628249 DQ310582.1 343 4.52223e-178 Callinectes sapidus arthrodial cuticle protein AMP16.3 mRNA, complete cds -- -- -- -- P81384 236 5.7e-19 Cuticle protein AMP1A OS=Homarus americanus PE=1 SV=1 PF03869//PF00379 Arc-like DNA binding domain//Insect cuticle protein -- -- GO:0042302//GO:0003677 structural constituent of cuticle//DNA binding -- -- -- -- Cluster-8309.2810 BP_3 14.00 1.42 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04147 Nop14-like family -- -- -- -- GO:0032040 small-subunit processome -- -- Cluster-8309.28101 BP_3 162.79 4.96 1873 642932331 XP_008197068.1 394 2.5e-35 PREDICTED: uncharacterized protein LOC103314051 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06624//PF01284//PF07947 Ribosome associated membrane protein RAMP4//Membrane-associating domain//YhhN-like protein -- -- -- -- GO:0005783//GO:0016020//GO:0016021 endoplasmic reticulum//membrane//integral component of membrane -- -- Cluster-8309.28102 BP_3 1.00 0.51 384 270015682 EFA12130.1 539 7.8e-53 hypothetical protein TcasGA2_TC002276 [Tribolium castaneum] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 303 7.5e-27 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF01384 Phosphate transporter family GO:0006817 phosphate ion transport GO:0005315 inorganic phosphate transmembrane transporter activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28103 BP_3 206.65 5.79 2011 642937978 XP_008199153.1 1992 1.4e-220 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 827549661 XM_012691461.1 35 3.16669e-06 PREDICTED: Bombyx mori ATP-binding cassette sub-family A member 1-like (LOC101740368), transcript variant X2, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 1002 3.5e-107 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF13304 AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28106 BP_3 28.61 0.78 2049 642937970 XP_008199149.1 1647 1.4e-180 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X2 [Tribolium castaneum] 827549661 XM_012691461.1 35 3.22758e-06 PREDICTED: Bombyx mori ATP-binding cassette sub-family A member 1-like (LOC101740368), transcript variant X2, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 855 3.9e-90 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF13304 AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28107 BP_3 11.13 1.96 566 642937978 XP_008199153.1 278 2.1e-22 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28108 BP_3 27.59 0.74 2092 642937970 XP_008199149.1 1954 3.6e-216 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X2 [Tribolium castaneum] 827549661 XM_012691461.1 35 3.2965e-06 PREDICTED: Bombyx mori ATP-binding cassette sub-family A member 1-like (LOC101740368), transcript variant X2, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 994 3.1e-106 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF01061//PF13304 ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28109 BP_3 18.73 0.51 2066 642937972 XP_008199150.1 1486 6.5e-162 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X3 [Tribolium castaneum] 827549661 XM_012691461.1 35 3.25483e-06 PREDICTED: Bombyx mori ATP-binding cassette sub-family A member 1-like (LOC101740368), transcript variant X2, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 758 7.0e-79 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF13304 AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28110 BP_3 193.84 1.68 5862 642937978 XP_008199153.1 5110 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 76 1.50757e-28 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 2835 0.0e+00 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00448//PF06414//PF13304//PF00005//PF04310//PF03193 SRP54-type protein, GTPase domain//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//MukB N-terminal//Protein of unknown function, DUF258 GO:0007059//GO:0030261//GO:0006614 chromosome segregation//chromosome condensation//SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0016887//GO:0016301//GO:0005524//GO:0003677//GO:0003924 GTP binding//ATPase activity//kinase activity//ATP binding//DNA binding//GTPase activity GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28111 BP_3 8.54 0.46 1178 642937968 XP_008199148.1 823 2.8e-85 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 374 1.3e-34 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF12513 Mitochondrial degradasome RNA helicase subunit C terminal -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28112 BP_3 13.00 6.78 382 780089478 XP_011673857.1 240 3.7e-18 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- K15503 ANKRD44 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K15503 Q4UMH6 234 7.5e-19 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28113 BP_3 9.89 0.50 1247 282403503 NP_001164147.1 1020 4.3e-108 fumble isoform 1 [Tribolium castaneum]>gi|642912441|ref|XP_008200861.1| PREDICTED: fumble isoform X1 [Tribolium castaneum] 746854770 XM_011059724.1 66 1.13636e-23 PREDICTED: Acromyrmex echinatior pantothenate kinase 3 (LOC105148170), transcript variant X9, mRNA K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q8K4K6 623 1.9e-63 Pantothenate kinase 1 OS=Mus musculus GN=Pank1 PE=1 SV=1 PF03630 Fumble GO:0015937//GO:0015940 coenzyme A biosynthetic process//pantothenate biosynthetic process GO:0004594//GO:0005524 pantothenate kinase activity//ATP binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.28114 BP_3 54.50 0.54 5121 282403503 NP_001164147.1 540 8.1e-52 fumble isoform 1 [Tribolium castaneum]>gi|642912441|ref|XP_008200861.1| PREDICTED: fumble isoform X1 [Tribolium castaneum] 746854770 XM_011059724.1 35 8.14653e-06 PREDICTED: Acromyrmex echinatior pantothenate kinase 3 (LOC105148170), transcript variant X9, mRNA K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q9BZ23 398 9.7e-37 Pantothenate kinase 2, mitochondrial OS=Homo sapiens GN=PANK2 PE=1 SV=3 PF00588//PF04433//PF03630 SpoU rRNA Methylase family//SWIRM domain//Fumble GO:0015937//GO:0006396//GO:0009451//GO:0015940 coenzyme A biosynthetic process//RNA processing//RNA modification//pantothenate biosynthetic process GO:0005515//GO:0008173//GO:0005524//GO:0004594//GO:0003723 protein binding//RNA methyltransferase activity//ATP binding//pantothenate kinase activity//RNA binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.28115 BP_3 8.00 9.80 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28116 BP_3 2.00 0.41 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28120 BP_3 2.00 2.06 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28121 BP_3 128.38 4.12 1794 332374190 AEE62236.1 1090 4.7e-116 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11165 DHRS7 dehydrogenase/reductase SDR family member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11165 Q9Y394 508 5.9e-50 Dehydrogenase/reductase SDR family member 7 OS=Homo sapiens GN=DHRS7 PE=1 SV=1 PF02558//PF01370//PF00106 Ketopantoate reductase PanE/ApbA//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152//GO:0015940 oxidation-reduction process//metabolic process//pantothenate biosynthetic process GO:0016491//GO:0050662//GO:0003824//GO:0008677 oxidoreductase activity//coenzyme binding//catalytic activity//2-dehydropantoate 2-reductase activity -- -- KOG1205 Predicted dehydrogenase Cluster-8309.28124 BP_3 569.02 10.83 2824 668449787 KFB39135.1 3530 0.0e+00 ATP-dependent RNA helicase [Anopheles sinensis] 572262617 XM_006609496.1 638 0 PREDICTED: Apis dorsata putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16-like (LOC102678016), mRNA K12813 DHX16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 http://www.genome.jp/dbget-bin/www_bget?ko:K12813 Q767K6 2853 0.0e+00 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Sus scrofa GN=DHX16 PE=3 SV=1 PF04408//PF14532//PF00448//PF07652//PF00437//PF00270 Helicase associated domain (HA2)//Sigma-54 interaction domain//SRP54-type protein, GTPase domain//Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase GO:0006355//GO:0006810//GO:0019079//GO:0006614 regulation of transcription, DNA-templated//transport//viral genome replication//SRP-dependent cotranslational protein targeting to membrane GO:0003676//GO:0005525//GO:0008134//GO:0008026//GO:0004386//GO:0005524 nucleic acid binding//GTP binding//transcription factor binding//ATP-dependent helicase activity//helicase activity//ATP binding GO:0005667 transcription factor complex KOG0923 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.28126 BP_3 161.00 1.81 4569 270006522 EFA02970.1 1613 2.7e-176 hypothetical protein TcasGA2_TC030691, partial [Tribolium castaneum] -- -- -- -- -- K16743 ASPM, ASP abnormal spindle-like microcephaly-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K16743 Q9VC45 1454 3.1e-159 Protein abnormal spindle OS=Drosophila melanogaster GN=asp PE=1 SV=3 PF00612//PF00307 IQ calmodulin-binding motif//Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0160 Myosin class V heavy chain Cluster-8309.28130 BP_3 280.19 4.31 3428 642937035 XP_008198661.1 2836 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X2 [Tribolium castaneum] 642937034 XM_008200439.1 587 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X2, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 2028 6.3e-226 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF00400//PF09266//PF11540 WD domain, G-beta repeat//Viral DNA topoisomerase I, N-terminal//Cytoplasmic dynein 1 intermediate chain 2 GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0003916//GO:0005515//GO:0003677 DNA topoisomerase activity//protein binding//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.28131 BP_3 1776.14 48.01 2075 642920385 XP_008192323.1 2134 4.8e-237 PREDICTED: UDP-glucuronosyltransferase 2C1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36514 641 2.6e-65 UDP-glucuronosyltransferase 2C1 (Fragment) OS=Oryctolagus cuniculus GN=UGT2C1 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.28132 BP_3 979.18 17.03 3063 642929465 XP_974907.2 1251 1.7e-134 PREDICTED: armadillo repeat-containing protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K486 859 2.0e-90 Armadillo repeat-containing protein 6 homolog OS=Drosophila melanogaster GN=CG5721 PE=1 SV=1 PF00514//PF02671 Armadillo/beta-catenin-like repeat//Paired amphipathic helix repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- KOG4199 Uncharacterized conserved protein Cluster-8309.28133 BP_3 40.00 1.94 1286 642932624 XP_008196925.1 916 5.1e-96 PREDICTED: prohormone-2-like [Tribolium castaneum]>gi|270012715|gb|EFA09163.1| NVP-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28136 BP_3 31.55 1.50 1308 91086913 XP_971407.1 729 2.5e-74 PREDICTED: serine/threonine-protein phosphatase 5 [Tribolium castaneum]>gi|270009672|gb|EFA06120.1| hypothetical protein TcasGA2_TC008963 [Tribolium castaneum] 817223205 XM_012431486.1 112 3.20319e-49 PREDICTED: Orussus abietinus serine/threonine-protein phosphatase 5 (LOC105703243), transcript variant X2, mRNA K04460 PPP5C serine/threonine-protein phosphatase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04460 P53041 622 2.6e-63 Serine/threonine-protein phosphatase 5 OS=Homo sapiens GN=PPP5C PE=1 SV=1 PF00149 Calcineurin-like phosphoesterase GO:0006470 protein dephosphorylation GO:0004721//GO:0046872//GO:0016787 phosphoprotein phosphatase activity//metal ion binding//hydrolase activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.2814 BP_3 4.59 0.38 871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03009 Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:0008081 phosphoric diester hydrolase activity -- -- -- -- Cluster-8309.28140 BP_3 7.92 0.44 1169 642932818 XP_008196998.1 1242 7.3e-134 PREDICTED: protein CLEC16A isoform X6 [Tribolium castaneum] -- -- -- -- -- K19513 CLEC16A protein CLEC16A http://www.genome.jp/dbget-bin/www_bget?ko:K19513 Q2KHT3 981 5.5e-105 Protein CLEC16A OS=Homo sapiens GN=CLEC16A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2219 Uncharacterized conserved protein Cluster-8309.28144 BP_3 142.11 1.22 5924 642926198 XP_008194826.1 5083 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein castor homolog 1-like [Tribolium castaneum] 645021609 XM_008209379.1 386 0 PREDICTED: Nasonia vitripennis zinc finger protein castor homolog 1-like (LOC100116283), partial mRNA -- -- -- -- Q7M3M8 884 4.9e-93 Transcription factor castor OS=Drosophila melanogaster GN=cas PE=1 SV=2 PF09026//PF06734//PF02178 Centromere protein B dimerisation domain//UL97//AT hook motif GO:0016032//GO:0006355 viral process//regulation of transcription, DNA-templated GO:0005524//GO:0003677//GO:0003682//GO:0004672 ATP binding//DNA binding//chromatin binding//protein kinase activity GO:0005634//GO:0000785//GO:0000775 nucleus//chromatin//chromosome, centromeric region -- -- Cluster-8309.28145 BP_3 20.00 0.81 1480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16422 Transcription factor COE1 DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.28148 BP_3 15.66 0.39 2216 189237118 XP_972118.2 2106 9.0e-234 PREDICTED: serine/threonine-protein kinase polo [Tribolium castaneum]>gi|270008199|gb|EFA04647.1| polo [Tribolium castaneum] -- -- -- -- -- K06631 PLK1 polo-like kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06631 P52304 1516 9.6e-167 Serine/threonine-protein kinase polo OS=Drosophila melanogaster GN=polo PE=1 SV=2 PF00659//PF07714//PF00069 POLO box duplicated region//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG0575 Polo-like serine/threonine protein kinase Cluster-8309.28149 BP_3 192.74 1.78 5503 642927663 XP_008195354.1 1331 1.6e-143 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 A0JNC2 395 2.3e-36 R3H domain-containing protein 2 OS=Bos taurus GN=R3HDM2 PE=2 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.2815 BP_3 414.58 14.88 1635 642921128 XP_008192699.1 1146 1.4e-122 PREDICTED: uncharacterized protein LOC664266 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16917 Biotin/lipoate A/B protein ligase family GO:0006464 cellular protein modification process -- -- -- -- -- -- Cluster-8309.28151 BP_3 781.52 6.59 6009 189241444 XP_972982.2 3186 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X1 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.3658e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 8.2e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF02346//PF01166 Chordopoxvirus multifunctional envelope protein A27//TSC-22/dip/bun family GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0019031//GO:0005667 viral envelope//transcription factor complex -- -- Cluster-8309.28155 BP_3 134.48 2.28 3129 642927580 XP_008195323.1 2471 6.0e-276 PREDICTED: uncharacterized protein LOC661513 isoform X1 [Tribolium castaneum]>gi|642927582|ref|XP_008195324.1| PREDICTED: uncharacterized protein LOC661513 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08622 Svf1-like GO:0006979 response to oxidative stress -- -- -- -- -- -- Cluster-8309.28157 BP_3 181.00 5.37 1917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28159 BP_3 836.00 42.36 1243 332375697 AEE62989.1 772 2.4e-79 unknown [Dendroctonus ponderosae] -- -- -- -- -- K04448 JUN transcription factor AP-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04448 P18289 373 1.9e-34 Transcription factor AP-1 OS=Drosophila melanogaster GN=Jra PE=1 SV=2 PF02544//PF03131//PF07716//PF00170//PF05853 3-oxo-5-alpha-steroid 4-dehydrogenase//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor//3-keto-5-aminohexanoate cleavage enzyme GO:0019475//GO:0006629//GO:0006355 L-lysine catabolic process to acetate//lipid metabolic process//regulation of transcription, DNA-templated GO:0016740//GO:0003677//GO:0043565//GO:0003700//GO:0016627 transferase activity//DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005634//GO:0005667//GO:0005737 integral component of membrane//nucleus//transcription factor complex//cytoplasm KOG0837 Transcriptional activator of the JUN family Cluster-8309.2816 BP_3 7.09 0.41 1130 642921128 XP_008192699.1 588 4.8e-58 PREDICTED: uncharacterized protein LOC664266 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28160 BP_3 6.00 0.37 1065 91089739 XP_975135.1 161 1.5e-08 PREDICTED: S-adenosylmethionine mitochondrial carrier protein homolog [Tribolium castaneum]>gi|270012648|gb|EFA09096.1| hypothetical protein TcasGA2_TC006818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.28162 BP_3 1353.01 20.33 3499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05241 Emopamil binding protein GO:0016125//GO:0006694 sterol metabolic process//steroid biosynthetic process GO:0047750 cholestenol delta-isomerase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28164 BP_3 4137.03 140.50 1711 57791222 AAW56441.1 199 9.3e-13 PR-5-like protein [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q9FSG7 165 3.4e-10 Thaumatin-like protein 1a OS=Malus domestica GN=TL1 PE=1 SV=1 PF05241 Emopamil binding protein GO:0006694//GO:0016125 steroid biosynthetic process//sterol metabolic process GO:0047750 cholestenol delta-isomerase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28166 BP_3 231.07 9.19 1504 478257322 ENN77482.1 595 9.9e-59 hypothetical protein YQE_06010, partial [Dendroctonus ponderosae]>gi|546679551|gb|ERL89999.1| hypothetical protein D910_07358 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VCG3 471 9.7e-46 Putative OPA3-like protein CG13603 OS=Drosophila melanogaster GN=CG13601 PE=2 SV=1 PF09429//PF05443//PF04218 WW domain binding protein 11//ROS/MUCR transcriptional regulator protein//CENP-B N-terminal DNA-binding domain GO:0006396//GO:0006355 RNA processing//regulation of transcription, DNA-templated GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- KOG3335 Predicted coiled-coil protein Cluster-8309.28169 BP_3 726.84 11.75 3272 91083107 XP_969706.1 1373 1.3e-148 PREDICTED: mitochondrial translocator assembly and maintenance protein 41 homolog [Tribolium castaneum] -- -- -- -- -- K17807 TAM41, MMP37 mitochondrial translocator assembly and maintenance protein 41 http://www.genome.jp/dbget-bin/www_bget?ko:K17807 Q3B7H2 731 1.5e-75 Phosphatidate cytidylyltransferase, mitochondrial OS=Danio rerio GN=tamm41 PE=2 SV=1 PF06687//PF06638 SUR7/PalI family//Strabismus protein GO:0007275 multicellular organismal development -- -- GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2986 Uncharacterized conserved protein Cluster-8309.2817 BP_3 3.00 0.87 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28170 BP_3 278.27 4.23 3462 642911313 XP_008199366.1 1106 1.3e-117 PREDICTED: ubiquitin carboxyl-terminal hydrolase 8-like isoform X1 [Tribolium castaneum]>gi|270014853|gb|EFA11301.1| hypothetical protein TcasGA2_TC010838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O57429 296 4.4e-25 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF00443//PF04805 Ubiquitin carboxyl-terminal hydrolase//E10-like protein conserved region GO:0055114//GO:0016579 oxidation-reduction process//protein deubiquitination GO:0016972//GO:0036459 thiol oxidase activity//ubiquitinyl hydrolase activity -- -- KOG1868 Ubiquitin C-terminal hydrolase Cluster-8309.28172 BP_3 63.73 0.66 4945 642922648 XP_008193260.1 1997 8.7e-221 PREDICTED: coiled-coil and C2 domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18260 CC2D1 coiled-coil and C2 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18260 Q29M42 1387 1.9e-151 Coiled-coil and C2 domain-containing protein 1-like OS=Drosophila pseudoobscura pseudoobscura GN=GA18377 PE=3 SV=2 PF00168//PF00711//PF04097 C2 domain//Beta defensin//Nup93/Nic96 GO:0006952//GO:0006810 defense response//transport GO:0005515 protein binding GO:0005576//GO:0005643 extracellular region//nuclear pore KOG3837 Uncharacterized conserved protein, contains DM14 and C2 domains Cluster-8309.28173 BP_3 1780.42 31.33 3031 571522843 XP_006560646.1 2547 9.0e-285 PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X1 [Apis mellifera]>gi|571522847|ref|XP_006560647.1| PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X2 [Apis mellifera]>gi|572299841|ref|XP_006616036.1| PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X1 [Apis dorsata]>gi|820834520|ref|XP_012348758.1| PREDICTED: zinc finger SWIM domain-containing protein 8 isoform X1 [Apis florea]>gi|820834522|ref|XP_012348809.1| PREDICTED: zinc finger SWIM domain-containing protein 8 isoform X1 [Apis florea] 642937303 XM_008200556.1 590 0 PREDICTED: Tribolium castaneum zinc finger SWIM domain-containing protein 8 (LOC659149), mRNA -- -- -- -- A7E2V4 1570 7.2e-173 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- KOG3615 Uncharacterized conserved protein Cluster-8309.28174 BP_3 2304.02 13.39 8586 642937304 XP_008198778.1 1898 4.6e-209 PREDICTED: zinc finger SWIM domain-containing protein 8 [Tribolium castaneum] 194892748 XM_001977686.1 154 9.6544e-72 Drosophila erecta GG19197 (Dere\GG19197), mRNA -- -- -- -- A7E2V4 868 5.1e-91 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 PF06554//PF02024 Olfactory marker protein//Leptin GO:0007165//GO:0007608 signal transduction//sensory perception of smell GO:0004871//GO:0005179 signal transducer activity//hormone activity GO:0005576 extracellular region KOG3615 Uncharacterized conserved protein Cluster-8309.28175 BP_3 87.28 0.79 5587 646717479 KDR20323.1 3194 0.0e+00 Adenylate cyclase type 2 [Zootermopsis nevadensis] 769847817 XM_011636959.1 159 1.04192e-74 PREDICTED: Pogonomyrmex barbatus adenylate cyclase type 2 (LOC105425936), transcript variant X4, mRNA K08042 ADCY2 adenylate cyclase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08042 Q08462 1839 8.5e-204 Adenylate cyclase type 2 OS=Homo sapiens GN=ADCY2 PE=1 SV=5 PF00211//PF07701//PF06327 Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated//Domain of Unknown Function (DUF1053) GO:0009190//GO:0035556//GO:0006171//GO:0006144//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//cAMP biosynthetic process//purine nucleobase metabolic process//GTP metabolic process//cGMP biosynthetic process GO:0004016//GO:0016849//GO:0004383 adenylate cyclase activity//phosphorus-oxygen lyase activity//guanylate cyclase activity GO:0005886 plasma membrane -- -- Cluster-8309.28176 BP_3 2499.70 24.10 5291 642918882 XP_008191626.1 2269 2.7e-252 PREDICTED: E3 ubiquitin-protein ligase TRIM33-like [Tribolium castaneum] 817217743 XM_012429361.1 488 0 PREDICTED: Orussus abietinus serine/threonine-protein kinase minibrain (LOC105702083), transcript variant X2, mRNA K08825 DYRK1 dual specificity tyrosine-phosphorylation-regulated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08825 P49657 1844 2.1e-204 Serine/threonine-protein kinase minibrain OS=Drosophila melanogaster GN=mnb PE=2 SV=2 PF07714//PF06180//PF01399//PF00069 Protein tyrosine kinase//Cobalt chelatase (CbiK)//PCI domain//Protein kinase domain GO:0006468//GO:0006783//GO:0019251 protein phosphorylation//heme biosynthetic process//anaerobic cobalamin biosynthetic process GO:0004672//GO:0005515//GO:0016852//GO:0005524 protein kinase activity//protein binding//sirohydrochlorin cobaltochelatase activity//ATP binding -- -- KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.28180 BP_3 1285.81 21.49 3175 91087645 XP_973337.1 857 8.7e-89 PREDICTED: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein [Tribolium castaneum]>gi|270010715|gb|EFA07163.1| hypothetical protein TcasGA2_TC010160 [Tribolium castaneum] -- -- -- -- -- K10904 TIPIN TIMELESS-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K10904 Q9BSE4 309 1.3e-26 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein OS=Homo sapiens GN=HERPUD2 PE=1 SV=2 PF03153//PF03623//PF00240//PF04513//PF05238//PF07962 Transcription factor IIA, alpha/beta subunit//Focal adhesion targeting region//Ubiquitin family//Baculovirus polyhedron envelope protein, PEP, C terminus//Kinetochore protein CHL4 like//Replication Fork Protection Component Swi3 GO:0007172//GO:0006367//GO:0007165//GO:0006468//GO:0006974//GO:0034508//GO:0007049//GO:0007059//GO:0048478 signal complex assembly//transcription initiation from RNA polymerase II promoter//signal transduction//protein phosphorylation//cellular response to DNA damage stimulus//centromere complex assembly//cell cycle//chromosome segregation//replication fork protection GO:0004713//GO:0005515//GO:0004871//GO:0005198 protein tyrosine kinase activity//protein binding//signal transducer activity//structural molecule activity GO:0005634//GO:0019031//GO:0005672//GO:0019028//GO:0005925 nucleus//viral envelope//transcription factor TFIIA complex//viral capsid//focal adhesion KOG3004 Meiotic chromosome segregation protein Cluster-8309.28181 BP_3 133.82 3.26 2271 642927745 XP_008195389.1 592 3.3e-58 PREDICTED: trafficking protein particle complex subunit 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXJ6 389 4.7e-36 Trafficking protein particle complex subunit 2-like protein OS=Taeniopygia guttata GN=TRAPPC2L PE=2 SV=1 PF13506//PF04628//PF04099 Glycosyl transferase family 21//Sedlin, N-terminal conserved region//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport GO:0016757 transferase activity, transferring glycosyl groups GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3444 Uncharacterized conserved protein Cluster-8309.28182 BP_3 308.12 8.69 2000 642927745 XP_008195389.1 646 1.6e-64 PREDICTED: trafficking protein particle complex subunit 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXJ6 429 9.6e-41 Trafficking protein particle complex subunit 2-like protein OS=Taeniopygia guttata GN=TRAPPC2L PE=2 SV=1 PF04099//PF04628 Sybindin-like family//Sedlin, N-terminal conserved region GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3444 Uncharacterized conserved protein Cluster-8309.28183 BP_3 2.06 0.31 612 642927745 XP_008195389.1 204 8.8e-14 PREDICTED: trafficking protein particle complex subunit 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXJ6 132 8.1e-07 Trafficking protein particle complex subunit 2-like protein OS=Taeniopygia guttata GN=TRAPPC2L PE=2 SV=1 PF04099//PF04628 Sybindin-like family//Sedlin, N-terminal conserved region GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005801//GO:0005622 cis-Golgi network//intracellular -- -- Cluster-8309.28185 BP_3 777.10 22.38 1965 91080393 XP_966637.1 1661 3.2e-182 PREDICTED: rab proteins geranylgeranyltransferase component A 1 [Tribolium castaneum]>gi|270005742|gb|EFA02190.1| hypothetical protein TcasGA2_TC007846 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V8W3 797 2.0e-83 Rab proteins geranylgeranyltransferase component A OS=Drosophila melanogaster GN=Rep PE=2 SV=1 PF12831 FAD dependent oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG4405 GDP dissociation inhibitor Cluster-8309.28187 BP_3 195.43 1.78 5586 373159263 AEY63781.1 2431 4.7e-271 ecdysone receptor isoform B [Monochamus alternatus] 373159262 JN616375.1 1222 0 Monochamus alternatus ecdysone receptor isoform B mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 O18531 1337 1.4e-145 Ecdysone receptor OS=Lucilia cuprina GN=EcR PE=2 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.28189 BP_3 18.95 1.16 1076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2819 BP_3 84.00 2.91 1685 91092662 XP_970551.1 677 3.4e-68 PREDICTED: suppressor protein SRP40 [Tribolium castaneum]>gi|270014855|gb|EFA11303.1| hypothetical protein TcasGA2_TC010840 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395//PF05793//PF02950 7tm Chemosensory receptor//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Conotoxin GO:0006367//GO:0050909//GO:0006810//GO:0032968//GO:0009405 transcription initiation from RNA polymerase II promoter//sensory perception of taste//transport//positive regulation of transcription elongation from RNA polymerase II promoter//pathogenesis GO:0008200//GO:0003677 ion channel inhibitor activity//DNA binding GO:0005576//GO:0016021//GO:0005634 extracellular region//integral component of membrane//nucleus -- -- Cluster-8309.28190 BP_3 53.07 0.46 5871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.28192 BP_3 2.00 1.15 373 642937480 XP_008198856.1 250 2.5e-19 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28194 BP_3 49.10 0.84 3121 642913640 XP_008201099.1 2668 8.6e-299 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum]>gi|642913648|ref|XP_008201103.1| PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 2.7e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF03539//PF01055 Spumavirus aspartic protease (A9)//Glycosyl hydrolases family 31 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004553//GO:0004190 hydrolase activity, hydrolyzing O-glycosyl compounds//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.28196 BP_3 48.73 0.48 5136 642912135 XP_008200821.1 2369 6.6e-264 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3-like [Tribolium castaneum] -- -- -- -- -- K08619 ADAMTS3 a disintegrin and metalloproteinase with thrombospondin motifs 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08619 O95450 1169 3.8e-126 A disintegrin and metalloproteinase with thrombospondin motifs 2 OS=Homo sapiens GN=ADAMTS2 PE=2 SV=2 PF05372//PF01421//PF08686 Delta lysin family//Reprolysin (M12B) family zinc metalloprotease//PLAC (protease and lacunin) domain GO:0019836//GO:0006508 hemolysis by symbiont of host erythrocytes//proteolysis GO:0004222//GO:0008233 metalloendopeptidase activity//peptidase activity GO:0005576 extracellular region -- -- Cluster-8309.28200 BP_3 521.37 2.43 10613 478253985 ENN74277.1 1811 6.9e-199 hypothetical protein YQE_09249, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7Z026 362 3.0e-32 Protein phosphatase 1 regulatory subunit 37 OS=Bos taurus GN=PPP1R37 PE=2 SV=1 PF14604//PF00560//PF00018//PF07123//PF13516//PF13855 Variant SH3 domain//Leucine Rich Repeat//SH3 domain//Photosystem II reaction centre W protein (PsbW)//Leucine Rich repeat//Leucine rich repeat GO:0015979 photosynthesis GO:0005515 protein binding GO:0009523//GO:0009507 photosystem II//chloroplast -- -- Cluster-8309.28204 BP_3 110.00 1.70 3414 270004166 EFA00614.1 166 1.3e-08 hypothetical protein TcasGA2_TC003489 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28208 BP_3 33.00 0.62 2863 642937480 XP_008198856.1 200 1.2e-12 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2821 BP_3 30.00 2.19 951 646720341 KDR22099.1 433 3.8e-40 Protein takeout [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O76879 253 1.2e-20 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28213 BP_3 1009.00 28.76 1983 91081015 XP_975227.1 621 1.3e-61 PREDICTED: uncharacterized protein LOC664119 [Tribolium castaneum]>gi|270005332|gb|EFA01780.1| hypothetical protein TcasGA2_TC007381 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00020//PF03839 TNFR/NGFR cysteine-rich region//Translocation protein Sec62 GO:0015031 protein transport GO:0005515//GO:0008565 protein binding//protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.28214 BP_3 37.00 0.73 2739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28216 BP_3 6.00 0.64 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28217 BP_3 830.82 3.02 13544 189234010 XP_972656.2 5202 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X4 [Tribolium castaneum]>gi|270014736|gb|EFA11184.1| hypothetical protein TcasGA2_TC004792 [Tribolium castaneum] 642911788 XM_967563.3 622 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 O15021 2428 1.0e-271 Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens GN=MAST4 PE=1 SV=3 PF08926//PF00069//PF06293//PF00595//PF00412//PF07714//PF13180 Domain of unknown function (DUF1908)//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PDZ domain (Also known as DHR or GLGF)//LIM domain//Protein tyrosine kinase//PDZ domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0004674//GO:0000287//GO:0008270//GO:0016773 protein binding//ATP binding//protein kinase activity//protein serine/threonine kinase activity//magnesium ion binding//zinc ion binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.2822 BP_3 294.00 6.31 2538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08131 Defensin-like peptide family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.28221 BP_3 7.86 0.88 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28222 BP_3 42.17 5.47 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28223 BP_3 231.80 4.57 2738 642935026 XP_008199911.1 218 9.4e-15 PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|642935028|ref|XP_008199912.1| PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|270012981|gb|EFA09429.1| hypothetical protein TcasGA2_TC010640 [Tribolium castaneum] -- -- -- -- -- K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q3T106 141 3.3e-07 Serine/arginine-rich splicing factor 7 OS=Bos taurus GN=SRSF7 PE=2 SV=1 PF01080//PF00098 Presenilin//Zinc knuckle -- -- GO:0005488//GO:0008270//GO:0003676//GO:0004190 binding//zinc ion binding//nucleic acid binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28224 BP_3 361.18 19.55 1182 642936522 XP_008198471.1 738 2.0e-75 PREDICTED: BRCA1-A complex subunit BRE-like [Tribolium castaneum]>gi|270014127|gb|EFA10575.1| hypothetical protein TcasGA2_TC012831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6SP92 375 1.0e-34 BRCA1-A complex subunit BRE OS=Mesocricetus auratus GN=Bre PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28225 BP_3 1270.10 18.88 3535 642923099 XP_008193609.1 2159 1.0e-239 PREDICTED: STE20/SPS1-related proline-alanine-rich protein kinase [Tribolium castaneum] 826417085 XM_012667875.1 233 4.79769e-116 PREDICTED: Monomorium pharaonis serine/threonine-protein kinase OSR1 (LOC105829196), transcript variant X2, mRNA K08835 OXSR1, STK39 serine/threonine-protein kinase OSR1/STK39 http://www.genome.jp/dbget-bin/www_bget?ko:K08835 Q863I2 1131 6.7e-122 Serine/threonine-protein kinase OSR1 OS=Sus scrofa GN=OXSR1 PE=2 SV=1 PF00069//PF07714//PF12202 Protein kinase domain//Protein tyrosine kinase//Oxidative-stress-responsive kinase 1 C terminal GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0582 Ste20-like serine/threonine protein kinase Cluster-8309.28226 BP_3 2744.71 31.59 4480 642934408 XP_008197648.1 2057 8.7e-228 PREDICTED: transport and Golgi organization protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VMA7 461 4.2e-44 Transport and Golgi organization protein 1 OS=Drosophila melanogaster GN=Tango1 PE=1 SV=2 PF05791//PF00038//PF00734 Bacillus haemolytic enterotoxin (HBL)//Intermediate filament protein//Fungal cellulose binding domain GO:0009405//GO:0005975 pathogenesis//carbohydrate metabolic process GO:0005198//GO:0004553//GO:0030248 structural molecule activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cellulose binding GO:0005882//GO:0016020//GO:0005576 intermediate filament//membrane//extracellular region -- -- Cluster-8309.28228 BP_3 169.87 1.22 7030 91078242 XP_970298.1 3559 0.0e+00 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 642939064 XM_008201985.1 402 0 PREDICTED: Tribolium castaneum xenotropic and polytropic retrovirus receptor 1 (LOC100142189), transcript variant X2, mRNA -- -- -- -- Q9UBH6 1815 6.5e-201 Xenotropic and polytropic retrovirus receptor 1 OS=Homo sapiens GN=XPR1 PE=1 SV=1 PF01504//PF03124 Phosphatidylinositol-4-phosphate 5-Kinase//EXS family GO:0046488 phosphatidylinositol metabolic process GO:0043167//GO:0016307 ion binding//phosphatidylinositol phosphate kinase activity GO:0016021 integral component of membrane KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.28230 BP_3 80.45 0.81 5086 642926029 XP_969555.3 1862 4.1e-205 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 3.71124e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 3.1e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28231 BP_3 184.13 1.12 8240 189234173 XP_968418.2 1427 1.8e-154 PREDICTED: RNA-binding protein Musashi homolog 2 isoform X2 [Tribolium castaneum] 642912293 XM_963325.3 503 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog 2 (LOC656824), transcript variant X2, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q96DH6 622 1.7e-62 RNA-binding protein Musashi homolog 2 OS=Homo sapiens GN=MSI2 PE=1 SV=1 PF00076//PF16367//PF01692//PF01371//PF01213//PF05014//PF08777//PF03852 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Paramyxovirus non-structural protein C//Trp repressor protein//Adenylate cyclase associated (CAP) N terminal//Nucleoside 2-deoxyribosyltransferase//RNA binding motif//DNA mismatch endonuclease Vsr GO:0006298//GO:0009159//GO:0007010//GO:0006355//GO:0030683//GO:0006206 mismatch repair//deoxyribonucleoside monophosphate catabolic process//cytoskeleton organization//regulation of transcription, DNA-templated//evasion or tolerance by virus of host immune response//pyrimidine nucleobase metabolic process GO:0003723//GO:0004519//GO:0070694//GO:0050144//GO:0003779//GO:0003676//GO:0003700 RNA binding//endonuclease activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//nucleoside deoxyribosyltransferase activity//actin binding//nucleic acid binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.28233 BP_3 52.00 15.31 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28234 BP_3 2283.24 41.09 2970 642916978 XP_008199580.1 1215 2.5e-130 PREDICTED: leukocyte receptor cluster member 8 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32NW2 800 1.4e-83 Leukocyte receptor cluster member 8 homolog OS=Xenopus laevis GN=leng8 PE=2 SV=1 PF01785//PF02978 Closterovirus coat protein//Signal peptide binding domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500//GO:0019012 signal recognition particle//virion KOG1861 Leucine permease transcriptional regulator Cluster-8309.28237 BP_3 2794.48 27.89 5121 642916974 XP_008199578.1 1043 3.8e-110 PREDICTED: leukocyte receptor cluster member 8 homolog isoform X1 [Tribolium castaneum]>gi|642916976|ref|XP_008199579.1| PREDICTED: leukocyte receptor cluster member 8 homolog isoform X1 [Tribolium castaneum]>gi|270003023|gb|EEZ99470.1| hypothetical protein TcasGA2_TC000041 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CBY3 733 1.4e-75 Leukocyte receptor cluster member 8 homolog OS=Mus musculus GN=Leng8 PE=1 SV=1 PF02978//PF01785 Signal peptide binding domain//Closterovirus coat protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500//GO:0019012 signal recognition particle//virion KOG1861 Leucine permease transcriptional regulator Cluster-8309.28238 BP_3 41.00 0.71 3058 642919488 XP_008191892.1 765 3.9e-78 PREDICTED: neuroglobin [Tribolium castaneum] 642919487 XM_008193670.1 226 3.22598e-112 PREDICTED: Tribolium castaneum neuroglobin (LOC663615), mRNA -- -- -- -- -- -- -- -- PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- -- -- Cluster-8309.2824 BP_3 102.59 8.34 885 642928441 XP_008193786.1 414 5.7e-38 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28240 BP_3 329.72 12.87 1527 91094389 XP_971252.1 775 1.4e-79 PREDICTED: DNA polymerase epsilon subunit C [Tribolium castaneum] 642910354 XM_966159.2 148 3.6495e-69 PREDICTED: Tribolium castaneum DNA polymerase epsilon subunit C (LOC659892), mRNA -- -- -- -- Q2YDP3 375 1.3e-34 Dr1-associated corepressor OS=Bos taurus GN=DRAP1 PE=2 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1659 Class 2 transcription repressor NC2, alpha subunit (DRAP1) Cluster-8309.28242 BP_3 192.00 2.97 3410 642912548 XP_008200908.1 187 4.6e-11 PREDICTED: collagen and calcium-binding EGF domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28243 BP_3 77.12 2.99 1533 270004866 EFA01314.1 291 1.8e-23 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K05465 ANGPT1 angiopoietin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05465 O18920 240 6.1e-19 Angiopoietin-1 OS=Bos taurus GN=ANGPT1 PE=2 SV=3 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.28245 BP_3 288.22 2.58 5678 478257634 ENN77786.1 3093 0.0e+00 hypothetical protein YQE_05757, partial [Dendroctonus ponderosae] -- -- -- -- -- K16602 TTLL5, TTLL10 tubulin polyglutamylase TTLL5 http://www.genome.jp/dbget-bin/www_bget?ko:K16602 Q8CHB8 1216 1.5e-131 Tubulin polyglutamylase TTLL5 OS=Mus musculus GN=Ttll5 PE=2 SV=3 PF02655//PF03133 ATP-grasp domain//Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process GO:0046872//GO:0005524 metal ion binding//ATP binding -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.28247 BP_3 496.68 4.47 5650 478257634 ENN77786.1 3093 0.0e+00 hypothetical protein YQE_05757, partial [Dendroctonus ponderosae] -- -- -- -- -- K16602 TTLL5, TTLL10 tubulin polyglutamylase TTLL5 http://www.genome.jp/dbget-bin/www_bget?ko:K16602 Q8CHB8 1216 1.5e-131 Tubulin polyglutamylase TTLL5 OS=Mus musculus GN=Ttll5 PE=2 SV=3 PF03133//PF02655 Tubulin-tyrosine ligase family//ATP-grasp domain GO:0006464 cellular protein modification process GO:0005524//GO:0046872 ATP binding//metal ion binding -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.28249 BP_3 2131.98 49.73 2358 86515378 NP_001034514.1 2289 5.8e-255 laccase 1 [Tribolium castaneum]>gi|642912767|ref|XP_008201239.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|642912769|ref|XP_008201241.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|642912771|ref|XP_008201242.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|68137818|gb|AAX84206.1| laccase 1 [Tribolium castaneum]>gi|270001917|gb|EEZ98364.1| hypothetical protein TcasGA2_TC000821 [Tribolium castaneum] 645006023 XM_008206069.1 60 4.71459e-20 PREDICTED: Nasonia vitripennis L-ascorbate oxidase-like (LOC100121373), mRNA -- -- -- -- Q96WM9 432 5.1e-41 Laccase-2 OS=Botryotinia fuckeliana GN=lcc2 PE=2 SV=1 PF07731//PF07732//PF00394 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0005507 metal ion binding//oxidoreductase activity//copper ion binding -- -- KOG1263 Multicopper oxidases Cluster-8309.2825 BP_3 154.90 12.27 900 642928441 XP_008193786.1 414 5.8e-38 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28252 BP_3 4.00 0.42 751 478255652 ENN75864.1 329 3.5e-28 hypothetical protein YQE_07593, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TD84 140 1.2e-07 Down syndrome cell adhesion molecule-like protein 1 OS=Homo sapiens GN=DSCAML1 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28254 BP_3 32.46 0.42 3989 189238033 XP_966902.2 1468 1.5e-159 PREDICTED: transmembrane protein 185A [Tribolium castaneum]>gi|270008773|gb|EFA05221.1| hypothetical protein TcasGA2_TC015362 [Tribolium castaneum] 642925153 XM_961809.3 242 5.38199e-121 PREDICTED: Tribolium castaneum transmembrane protein 185A (LOC655280), mRNA -- -- -- -- Q8R3R5 844 1.4e-88 Transmembrane protein 185B OS=Mus musculus GN=Tmem185b PE=2 SV=1 PF05443//PF02535 ROS/MUCR transcriptional regulator protein//ZIP Zinc transporter GO:0055085//GO:0006355//GO:0030001 transmembrane transport//regulation of transcription, DNA-templated//metal ion transport GO:0046873//GO:0003677//GO:0008270 metal ion transmembrane transporter activity//DNA binding//zinc ion binding GO:0016020 membrane KOG3879 Predicted membrane protein Cluster-8309.28257 BP_3 9.00 0.54 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.2826 BP_3 4.00 0.50 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28260 BP_3 379.99 10.72 2000 91078258 XP_970899.1 1875 5.0e-207 PREDICTED: conserved oligomeric Golgi complex subunit 6 [Tribolium castaneum]>gi|270003921|gb|EFA00369.1| hypothetical protein TcasGA2_TC003211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V564 1377 1.1e-150 Conserved oligomeric Golgi complex subunit 6 OS=Drosophila melanogaster GN=CG1968 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3758 Uncharacterized conserved protein Cluster-8309.28262 BP_3 210.96 5.24 2232 642910457 XP_008190746.1 2112 1.8e-234 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum]>gi|642910459|ref|XP_008190747.1| PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum] 462340826 APGK01036266.1 75 2.04536e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q09147 1216 5.9e-132 Fibroblast growth factor receptor homolog 2 OS=Drosophila melanogaster GN=btl PE=2 SV=3 PF13895//PF02313//PF00069//PF06305//PF07714 Immunoglobulin domain//Fumarate reductase subunit D//Protein kinase domain//Protein of unknown function (DUF1049)//Protein tyrosine kinase GO:0006106//GO:0006468 fumarate metabolic process//protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity GO:0016020//GO:0005887 membrane//integral component of plasma membrane -- -- Cluster-8309.28263 BP_3 184.93 10.41 1148 642910457 XP_008190746.1 468 4.0e-44 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum]>gi|642910459|ref|XP_008190747.1| PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 268 2.6e-22 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28264 BP_3 44.75 0.80 3002 642910461 XP_008190748.1 2005 6.3e-222 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] 462340826 APGK01036266.1 75 2.76042e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1199 7.5e-130 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF02313//PF00069//PF07714//PF06305 Fumarate reductase subunit D//Protein kinase domain//Protein tyrosine kinase//Protein of unknown function (DUF1049) GO:0006106//GO:0006468 fumarate metabolic process//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.28266 BP_3 2.00 2.06 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28267 BP_3 4.00 1.25 445 270015126 EFA11574.1 153 5.2e-08 heartless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28269 BP_3 297.00 7.56 2186 91081337 XP_970723.1 999 2.0e-105 PREDICTED: retinol dehydrogenase 12 [Tribolium castaneum]>gi|270006107|gb|EFA02555.1| hypothetical protein TcasGA2_TC008262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5I4 408 2.9e-38 Dehydrogenase/reductase SDR family member on chromosome X OS=Homo sapiens GN=DHRSX PE=2 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.2827 BP_3 30.00 1.55 1223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28270 BP_3 378.00 30.45 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28271 BP_3 237.75 2.68 4561 642910521 XP_008200247.1 918 1.1e-95 PREDICTED: muscle M-line assembly protein unc-89-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28272 BP_3 110.76 1.68 3478 546674875 ERL86161.1 2677 8.7e-300 hypothetical protein D910_03574 [Dendroctonus ponderosae] -- -- -- -- -- K12796 ERBB2IP, ERBIN erbb2-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12796 Q9V780 795 6.1e-83 Protein lap1 OS=Drosophila melanogaster GN=Lap1 PE=2 SV=1 PF13855//PF13180//PF00595//PF00560 Leucine rich repeat//PDZ domain//PDZ domain (Also known as DHR or GLGF)//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.28273 BP_3 64.08 1.26 2737 91088333 XP_970609.1 1155 2.1e-123 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 706 1.0e-72 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF00083//PF15281 Major Facilitator Superfamily//Sugar (and other) transporter//Consortin C-terminus GO:0042998//GO:0055085 positive regulation of Golgi to plasma membrane protein transport//transmembrane transport GO:0071253//GO:0022857 connexin binding//transmembrane transporter activity GO:0005802//GO:0016021 trans-Golgi network//integral component of membrane -- -- Cluster-8309.28277 BP_3 164.58 1.21 6865 478256710 ENN76892.1 1622 3.7e-177 hypothetical protein YQE_06733, partial [Dendroctonus ponderosae]>gi|546685091|gb|ERL94618.1| hypothetical protein D910_11895 [Dendroctonus ponderosae] 749732005 XM_011139608.1 229 1.56615e-113 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1333 4.9e-145 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF06293//PF00069//PF02434//PF07714//PF01762//PF13414 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Fringe-like//Protein tyrosine kinase//Galactosyltransferase//TPR repeat GO:0006468//GO:0006486 protein phosphorylation//protein glycosylation GO:0016757//GO:0005524//GO:0005515//GO:0016773//GO:0004672//GO:0008378 transferase activity, transferring glycosyl groups//ATP binding//protein binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//galactosyltransferase activity GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.28279 BP_3 13.23 0.31 2344 91085211 XP_972225.1 1563 8.8e-171 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009079|gb|EFA05527.1| hypothetical protein TcasGA2_TC015714 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 951 3.3e-101 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF07992//PF05834//PF00732//PF01266//PF00070//PF05199//PF02254 Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0006813//GO:0055114 carotenoid biosynthetic process//potassium ion transport//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.28281 BP_3 284.00 17.06 1094 642919584 XP_975311.2 687 1.5e-69 PREDICTED: probable trafficking protein particle complex subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUZ1 531 7.8e-53 Probable trafficking protein particle complex subunit 2 OS=Drosophila melanogaster GN=Trs20 PE=2 SV=2 PF04628//PF04099 Sedlin, N-terminal conserved region//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3487 TRAPP 20 K subunit Cluster-8309.28282 BP_3 131.94 2.58 2757 91085407 XP_967344.1 1098 8.6e-117 PREDICTED: peroxisome assembly protein 12 [Tribolium castaneum] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 2.0e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF07685//PF13639//PF12678//PF00097 CobB/CobQ-like glutamine amidotransferase domain//Ring finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0046872//GO:0008270//GO:0003824 protein binding//metal ion binding//zinc ion binding//catalytic activity -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.28283 BP_3 1.00 8.38 248 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28286 BP_3 106.52 1.43 3892 642925008 XP_008194132.1 2136 5.2e-237 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X2 [Tribolium castaneum] 687916150 LK995546.1 47 1.31843e-12 Rhabditophanes sp. KR3021 genome assembly Rhabditophanes_sp_KR3021 ,scaffold RSKR_scaffold0000001 K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 1763 3.9e-195 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03485//PF05236//PF15014//PF03540 Arginyl tRNA synthetase N terminal domain//Transcription initiation factor TFIID component TAF4 family//Ceroid-lipofuscinosis neuronal protein 5//Transcription initiation factor TFIID 23-30kDa subunit GO:0006352//GO:0006420//GO:0006560//GO:0022008//GO:0006525 DNA-templated transcription, initiation//arginyl-tRNA aminoacylation//proline metabolic process//neurogenesis//arginine metabolic process GO:0000166//GO:0004814//GO:0005524 nucleotide binding//arginine-tRNA ligase activity//ATP binding GO:0005737//GO:0005669//GO:0005764//GO:0005634 cytoplasm//transcription factor TFIID complex//lysosome//nucleus KOG3635 Phosphorylase kinase Cluster-8309.28287 BP_3 227.69 3.61 3332 642929247 XP_008195752.1 173 1.9e-09 PREDICTED: uncharacterized protein LOC103313669 [Tribolium castaneum]>gi|270010484|gb|EFA06932.1| hypothetical protein TcasGA2_TC009882 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09788 Transmembrane protein 55A GO:0046856 phosphatidylinositol dephosphorylation GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity -- -- -- -- Cluster-8309.28288 BP_3 652.20 8.10 4174 642925626 XP_008194646.1 3000 0.0e+00 PREDICTED: endothelin-converting enzyme 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 P42893 1657 8.1e-183 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF05649//PF01447//PF01431 Peptidase family M13//Thermolysin metallopeptidase, catalytic domain//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.28290 BP_3 616.20 7.11 4471 642912875 XP_008201292.1 4481 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X9 [Tribolium castaneum]>gi|270001881|gb|EEZ98328.1| hypothetical protein TcasGA2_TC000782 [Tribolium castaneum] 642912874 XM_008203070.1 1050 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1712 3.6e-189 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00609//PF00788//PF00076//PF00781 Diacylglycerol kinase accessory domain//Ras association (RalGDS/AF-6) domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase catalytic domain GO:0009395//GO:0007205//GO:0007165//GO:0046486//GO:0035556 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//signal transduction//glycerolipid metabolic process//intracellular signal transduction GO:0004143//GO:0046872//GO:0003676//GO:0016301//GO:0000166 diacylglycerol kinase activity//metal ion binding//nucleic acid binding//kinase activity//nucleotide binding GO:0005622 intracellular KOG1169 Diacylglycerol kinase Cluster-8309.28293 BP_3 42.75 0.67 3363 642926733 XP_008194990.1 2284 3.1e-254 PREDICTED: protein Malvolio isoform X2 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1804 5.9e-200 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF01566//PF08089//PF15168 Natural resistance-associated macrophage protein//Huwentoxin-II family//Triple QxxK/R motif-containing protein family GO:0009405//GO:0006810 pathogenesis//transport GO:0005215 transporter activity GO:0005576//GO:0016020//GO:0005789 extracellular region//membrane//endoplasmic reticulum membrane KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.28294 BP_3 110.00 12.15 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28295 BP_3 98.57 7.49 926 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28296 BP_3 199.01 1.33 7482 91081101 XP_975504.1 3888 0.0e+00 PREDICTED: DNA topoisomerase 3-beta-1 [Tribolium castaneum]>gi|270005298|gb|EFA01746.1| hypothetical protein TcasGA2_TC007344 [Tribolium castaneum] -- -- -- -- -- K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 O95985 2923 0.0e+00 DNA topoisomerase 3-beta-1 OS=Homo sapiens GN=TOP3B PE=1 SV=1 PF13855//PF04421//PF01131//PF00560 Leucine rich repeat//Mss4 protein//DNA topoisomerase//Leucine Rich Repeat GO:0006265//GO:0007264//GO:0043087 DNA topological change//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005515//GO:0003916//GO:0003677//GO:0003917//GO:0005085 protein binding//DNA topoisomerase activity//DNA binding//DNA topoisomerase type I activity//guanyl-nucleotide exchange factor activity GO:0005694 chromosome KOG1956 DNA topoisomerase III alpha Cluster-8309.28299 BP_3 13.75 0.55 1496 820805576 AKG92779.1 314 3.8e-26 dimmed [Leptinotarsa decemlineata] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 200 2.6e-14 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.283 BP_3 4.00 0.77 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2830 BP_3 2247.46 42.31 2852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28300 BP_3 1008.01 20.31 2684 270012119 EFA08567.1 489 3.5e-46 hypothetical protein TcasGA2_TC006222 [Tribolium castaneum] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 193 3.0e-13 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.28301 BP_3 459.36 17.71 1542 91094739 XP_971002.1 702 4.0e-71 PREDICTED: uncharacterized protein LOC659618 [Tribolium castaneum]>gi|270010786|gb|EFA07234.1| hypothetical protein TcasGA2_TC010591 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BN57 213 8.3e-16 Protein C3orf33 homolog OS=Mus musculus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28304 BP_3 308.10 5.25 3119 546679851 ERL90239.1 1039 6.7e-110 hypothetical protein D910_07592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83548 613 6.9e-62 Vanin-like protein 3 OS=Drosophila melanogaster GN=CG32750 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.28305 BP_3 252.55 4.50 2994 270007326 EFA03774.1 1530 7.5e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 843 1.4e-88 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF02456//PF01612//PF08066 Adenovirus IVa2 protein//3'-5' exonuclease//PMC2NT (NUC016) domain GO:0006139//GO:0006396//GO:0019083 nucleobase-containing compound metabolic process//RNA processing//viral transcription GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.28306 BP_3 163.98 1.88 4485 189237458 XP_967667.2 1458 2.5e-158 PREDICTED: solute carrier family 35 member E2-like [Tribolium castaneum] -- -- -- -- -- K15284 SLC35E2 solute carrier family 35, member E2 http://www.genome.jp/dbget-bin/www_bget?ko:K15284 Q8C811 857 5.1e-90 Solute carrier family 35 member E2 OS=Mus musculus GN=Slc35e2 PE=2 SV=1 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.28309 BP_3 25.45 0.64 2215 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28311 BP_3 280.18 2.13 6637 675379920 KFM72822.1 1258 5.8e-135 Transposable element P transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF07967 THAP domain//C3HC zinc finger-like -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28313 BP_3 229.98 1.70 6798 546680752 ERL90967.1 872 3.4e-90 hypothetical protein D910_08309 [Dendroctonus ponderosae] 225543471 NM_001145912.1 198 2.65067e-96 Tribolium castaneum synaptotagmin 1 (Syt1), mRNA K15290 SYT1 synaptotagmin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15290 P21521 764 4.7e-79 Synaptotagmin 1 OS=Drosophila melanogaster GN=Syt1 PE=1 SV=3 PF03821//PF05478//PF00168 Golgi 4-transmembrane spanning transporter//Prominin//C2 domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.28314 BP_3 644.00 11.88 2904 332374358 AEE62320.1 1962 5.9e-217 unknown [Dendroctonus ponderosae]>gi|478257144|gb|ENN77307.1| hypothetical protein YQE_06133, partial [Dendroctonus ponderosae]>gi|546681450|gb|ERL91547.1| hypothetical protein D910_08877 [Dendroctonus ponderosae] -- -- -- -- -- K14406 CSTF1 cleavage stimulation factor subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14406 Q05048 1272 2.5e-138 Cleavage stimulation factor subunit 1 OS=Homo sapiens GN=CSTF1 PE=1 SV=1 PF00578//PF00085//PF02532//PF01323//PF00400//PF01400 AhpC/TSA family//Thioredoxin//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//DSBA-like thioredoxin domain//WD domain, G-beta repeat//Astacin (Peptidase family M12A) GO:0015979//GO:0006118//GO:0006508//GO:0055114//GO:0045454 photosynthesis//obsolete electron transport//proteolysis//oxidation-reduction process//cell redox homeostasis GO:0004222//GO:0005515//GO:0016491//GO:0016209//GO:0015035 metalloendopeptidase activity//protein binding//oxidoreductase activity//antioxidant activity//protein disulfide oxidoreductase activity GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center KOG0640 mRNA cleavage stimulating factor complex; subunit 1 Cluster-8309.28315 BP_3 253.00 9.36 1594 795014013 XP_011883732.1 194 3.3e-12 PREDICTED: uncharacterized protein LOC105570890 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q9SDW0 127 8.0e-06 Trihelix transcription factor GT-3a OS=Arabidopsis thaliana GN=GT-3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28319 BP_3 302.05 2.54 6034 270011049 EFA07497.1 1806 1.5e-198 schnurri [Tribolium castaneum] -- -- -- -- -- K09239 HIVEP human immunodeficiency virus type I enhancer-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09239 A2A884 339 7.9e-30 Transcription factor HIVEP3 OS=Mus musculus GN=Hivep3 PE=1 SV=1 PF00096//PF13465//PF00651 Zinc finger, C2H2 type//Zinc-finger double domain//BTB/POZ domain -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- -- -- Cluster-8309.28320 BP_3 301.64 7.51 2228 820805528 AKG92755.1 1053 1.1e-111 hairy [Leptinotarsa decemlineata] 529156840 KC999046.1 46 2.69768e-12 Platynereis dumerilii hairy enhancer of split 8 (Hes8) mRNA, complete cds K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 P14003 574 1.6e-57 Protein hairy OS=Drosophila melanogaster GN=h PE=1 SV=2 PF00010//PF07527 Helix-loop-helix DNA-binding domain//Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.28321 BP_3 15.73 0.36 2407 820805528 AKG92755.1 963 3.4e-101 hairy [Leptinotarsa decemlineata] 529156840 KC999046.1 42 4.88264e-10 Platynereis dumerilii hairy enhancer of split 8 (Hes8) mRNA, complete cds K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 P14003 560 7.5e-56 Protein hairy OS=Drosophila melanogaster GN=h PE=1 SV=2 PF07527//PF00010 Hairy Orange//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.28322 BP_3 11.63 0.34 1921 820805528 AKG92755.1 800 2.1e-82 hairy [Leptinotarsa decemlineata] -- -- -- -- -- K09090 HESN hairy and enhancer of split, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09090 P14003 403 9.6e-38 Protein hairy OS=Drosophila melanogaster GN=h PE=1 SV=2 PF07527 Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.28323 BP_3 14.44 0.40 2050 91094295 XP_971662.1 1658 7.4e-182 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 1449 5.2e-159 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF02770//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.28324 BP_3 38.00 0.76 2694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01254//PF06495//PF04940 Nuclear transition protein 2//Fruit fly transformer protein//Sensors of blue-light using FAD GO:0007283//GO:0046660//GO:0006397//GO:0007165 spermatogenesis//female sex differentiation//mRNA processing//signal transduction GO:0071949//GO:0003677//GO:0009882 FAD binding//DNA binding//blue light photoreceptor activity GO:0000786//GO:0005634 nucleosome//nucleus -- -- Cluster-8309.28325 BP_3 1493.30 474.22 443 270016365 EFA12811.1 175 1.5e-10 hypothetical protein TcasGA2_TC001876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28327 BP_3 472.00 16.79 1647 91079450 XP_969249.1 1799 2.7e-198 PREDICTED: venom serine carboxypeptidase [Tribolium castaneum]>gi|270016070|gb|EFA12518.1| hypothetical protein TcasGA2_TC002692 [Tribolium castaneum] -- -- -- -- -- K09645 CPVL vitellogenic carboxypeptidase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K09645 C9WMM5 1369 7.9e-150 Venom serine carboxypeptidase OS=Apis mellifera PE=2 SV=1 PF00450 Serine carboxypeptidase GO:0006508 proteolysis GO:0004185 serine-type carboxypeptidase activity -- -- KOG1282 Serine carboxypeptidases (lysosomal cathepsin A) Cluster-8309.28328 BP_3 128.00 1.86 3606 478254748 ENN74985.1 1310 2.9e-141 hypothetical protein YQE_08442, partial [Dendroctonus ponderosae] 198455838 XM_001360087.2 43 2.04256e-10 Drosophila pseudoobscura pseudoobscura GA17177 (Dpse\GA17177), partial mRNA K04577 CALCRL calcitonin receptor-like http://www.genome.jp/dbget-bin/www_bget?ko:K04577 Q8AXU4 529 4.4e-52 Calcitonin gene-related peptide type 1 receptor OS=Oncorhynchus gorbuscha GN=calcrl PE=2 SV=1 PF00002//PF09384//PF02793 7 transmembrane receptor (Secretin family)//UTP15 C terminal//Hormone receptor domain GO:0006364//GO:0007186 rRNA processing//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021//GO:0005730 membrane//integral component of membrane//nucleolus -- -- Cluster-8309.28330 BP_3 251.00 1.96 6466 768438384 XP_011560772.1 315 1.3e-25 PREDICTED: transient receptor potential cation channel protein painless [Plutella xylostella]>gi|768438386|ref|XP_011560773.1| PREDICTED: transient receptor potential cation channel protein painless [Plutella xylostella] -- -- -- -- -- -- -- -- -- O90760 163 2.2e-09 Putative ankyrin repeat protein FPV031 OS=Fowlpox virus (strain NVSL) GN=ANK3 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28332 BP_3 324.94 4.76 3579 642918959 XP_008191673.1 1817 4.7e-200 PREDICTED: NEDD8 ultimate buster 1-like [Tribolium castaneum]>gi|270005608|gb|EFA02056.1| hypothetical protein TcasGA2_TC007685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54729 611 1.4e-61 NEDD8 ultimate buster 1 OS=Mus musculus GN=Nub1 PE=1 SV=2 PF13374//PF00240//PF17050//PF13414//PF03711 Tetratricopeptide repeat//Ubiquitin family//Altered inheritance of mitochondria 5//TPR repeat//Orn/Lys/Arg decarboxylase, C-terminal domain GO:0042407 cristae formation GO:0003824//GO:0005515 catalytic activity//protein binding GO:0061617//GO:0044284 MICOS complex//mitochondrial crista junction KOG2561 Adaptor protein NUB1, contains UBA domain Cluster-8309.28333 BP_3 25.00 10.01 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28336 BP_3 141.46 1.60 4541 478251870 ENN72309.1 1219 1.3e-130 hypothetical protein YQE_11052, partial [Dendroctonus ponderosae] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 943 5.5e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF08241//PF08245//PF09445//PF14750//PF02875//PF02086 Methyltransferase domain//Mur ligase middle domain//RNA cap guanine-N2 methyltransferase//Integrator complex subunit 2//Mur ligase family, glutamate ligase domain//D12 class N6 adenine-specific DNA methyltransferase GO:0001510//GO:0009452//GO:0032775//GO:0008152//GO:0006306//GO:0009058 RNA methylation//7-methylguanosine RNA capping//DNA methylation on adenine//metabolic process//DNA methylation//biosynthetic process GO:0005524//GO:0016874//GO:0008168//GO:0009007 ATP binding//ligase activity//methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity GO:0032039 integrator complex KOG2525 Folylpolyglutamate synthase Cluster-8309.28337 BP_3 233.96 2.60 4621 478251870 ENN72309.1 1219 1.3e-130 hypothetical protein YQE_11052, partial [Dendroctonus ponderosae] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 943 5.6e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF08241//PF08245//PF14750//PF09445//PF02086//PF02875 Methyltransferase domain//Mur ligase middle domain//Integrator complex subunit 2//RNA cap guanine-N2 methyltransferase//D12 class N6 adenine-specific DNA methyltransferase//Mur ligase family, glutamate ligase domain GO:0008152//GO:0032775//GO:0009452//GO:0001510//GO:0009058//GO:0006306 metabolic process//DNA methylation on adenine//7-methylguanosine RNA capping//RNA methylation//biosynthetic process//DNA methylation GO:0016874//GO:0005524//GO:0009007//GO:0008168 ligase activity//ATP binding//site-specific DNA-methyltransferase (adenine-specific) activity//methyltransferase activity GO:0032039 integrator complex KOG2525 Folylpolyglutamate synthase Cluster-8309.28346 BP_3 1079.40 8.44 6455 546682046 ERL92032.1 1889 3.8e-208 hypothetical protein D910_09354, partial [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.29464e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.8e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF00400//PF01435//PF03650//PF06784//PF03598//PF12317 WD domain, G-beta repeat//Peptidase family M48//Uncharacterised protein family (UPF0041)//Uncharacterised protein family (UPF0240)//CO dehydrogenase/acetyl-CoA synthase complex beta subunit//Intraflagellar transport complex B protein 46 C terminal GO:0006508//GO:0032981//GO:0042073//GO:0015947//GO:0006084//GO:0006850 proteolysis//mitochondrial respiratory chain complex I assembly//intraciliary transport//methane metabolic process//acetyl-CoA metabolic process//mitochondrial pyruvate transport GO:0018492//GO:0004222//GO:0005515 carbon-monoxide dehydrogenase (acceptor) activity//metalloendopeptidase activity//protein binding GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.28347 BP_3 122.35 0.94 6579 332373884 AEE62083.1 1889 3.9e-208 unknown [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.39693e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.9e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF06784//PF12317//PF03598//PF00400//PF01435//PF03650 Uncharacterised protein family (UPF0240)//Intraflagellar transport complex B protein 46 C terminal//CO dehydrogenase/acetyl-CoA synthase complex beta subunit//WD domain, G-beta repeat//Peptidase family M48//Uncharacterised protein family (UPF0041) GO:0006850//GO:0015947//GO:0006084//GO:0042073//GO:0032981//GO:0006508 mitochondrial pyruvate transport//methane metabolic process//acetyl-CoA metabolic process//intraciliary transport//mitochondrial respiratory chain complex I assembly//proteolysis GO:0005515//GO:0004222//GO:0018492 protein binding//metalloendopeptidase activity//carbon-monoxide dehydrogenase (acceptor) activity GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.28349 BP_3 675.01 5.33 6396 478255559 ENN75776.1 1889 3.8e-208 hypothetical protein YQE_07733, partial [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.24597e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.8e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF06784//PF12317//PF03598//PF00400//PF03650//PF01435 Uncharacterised protein family (UPF0240)//Intraflagellar transport complex B protein 46 C terminal//CO dehydrogenase/acetyl-CoA synthase complex beta subunit//WD domain, G-beta repeat//Uncharacterised protein family (UPF0041)//Peptidase family M48 GO:0006084//GO:0015947//GO:0006850//GO:0032981//GO:0006508//GO:0042073 acetyl-CoA metabolic process//methane metabolic process//mitochondrial pyruvate transport//mitochondrial respiratory chain complex I assembly//proteolysis//intraciliary transport GO:0004222//GO:0005515//GO:0018492 metalloendopeptidase activity//protein binding//carbon-monoxide dehydrogenase (acceptor) activity GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.28351 BP_3 733.94 14.14 2794 642914462 XP_008201687.1 952 7.4e-100 PREDICTED: potassium channel subfamily K member 6-like isoform X1 [Tribolium castaneum]>gi|270001497|gb|EEZ97944.1| hypothetical protein TcasGA2_TC000334 [Tribolium castaneum] -- -- -- -- -- K04912 KCNK1 potassium channel subfamily K member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04912 O00180 470 2.4e-45 Potassium channel subfamily K member 1 OS=Homo sapiens GN=KCNK1 PE=1 SV=1 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.28354 BP_3 133.60 0.71 9351 642937629 XP_008198876.1 4353 0.0e+00 PREDICTED: tubby-related protein 4 [Tribolium castaneum] 462288762 APGK01055065.1 72 4.03176e-26 Dendroctonus ponderosae Seq01055075, whole genome shotgun sequence -- -- -- -- Q9JIL5 1348 1.2e-146 Tubby-related protein 4 OS=Mus musculus GN=Tulp4 PE=2 SV=1 PF07525//PF00961 SOCS box//LAGLIDADG endonuclease GO:0035556 intracellular signal transduction GO:0004519 endonuclease activity -- -- KOG2503 Tubby superfamily protein TULP4 Cluster-8309.28355 BP_3 316.66 1.31 11906 642937629 XP_008198876.1 4353 0.0e+00 PREDICTED: tubby-related protein 4 [Tribolium castaneum] 462288762 APGK01055065.1 72 5.13775e-26 Dendroctonus ponderosae Seq01055075, whole genome shotgun sequence -- -- -- -- Q9JIL5 1348 1.6e-146 Tubby-related protein 4 OS=Mus musculus GN=Tulp4 PE=2 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- KOG2503 Tubby superfamily protein TULP4 Cluster-8309.28357 BP_3 2.00 0.41 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363//PF07776//PF05191//PF03943 FYVE zinc finger//Zinc-finger associated domain (zf-AD)//Adenylate kinase, active site lid//TAP C-terminal domain GO:0006144//GO:0051028//GO:0046034 purine nucleobase metabolic process//mRNA transport//ATP metabolic process GO:0008270//GO:0004017//GO:0046872 zinc ion binding//adenylate kinase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.28358 BP_3 9.00 21.56 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28359 BP_3 1.00 14.32 234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2836 BP_3 82.87 1.46 3027 642927347 XP_008195231.1 726 1.3e-73 PREDICTED: uncharacterized protein C1orf112 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NSG2 157 5.0e-09 Uncharacterized protein C1orf112 OS=Homo sapiens GN=C1orf112 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28360 BP_3 6.00 1.88 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28362 BP_3 2.00 0.40 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28364 BP_3 245.92 22.10 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF06784 Zinc-finger associated domain (zf-AD)//Uncharacterised protein family (UPF0240) GO:0032981 mitochondrial respiratory chain complex I assembly GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28365 BP_3 2.00 0.48 494 260810939 XP_002600180.1 203 9.2e-14 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- G3V893 126 3.2e-06 Zinc finger protein 335 OS=Rattus norvegicus GN=Znf335 PE=1 SV=1 PF00096//PF01155//PF07649 Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//C1-like domain GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0016151//GO:0046872//GO:0047134 nickel cation binding//metal ion binding//protein-disulfide reductase activity -- -- -- -- Cluster-8309.28367 BP_3 213.60 9.30 1399 642930375 XP_008196372.1 617 2.6e-61 PREDICTED: myosin-2 essential light chain isoform X1 [Tribolium castaneum] 389608774 AK401377.1 83 4.53502e-33 Papilio xuthus mRNA for myosin light chain cytoplasmic, complete cds, sequence id: Px-0488 K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 P54357 466 3.4e-45 Myosin-2 essential light chain OS=Drosophila melanogaster GN=Mlc-c PE=1 SV=1 PF13202//PF13833//PF13405//PF00036//PF13499 EF hand//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.28368 BP_3 5801.07 146.52 2200 160333785 NP_001103903.1 2227 8.3e-248 chitin deacetylase 4 precursor [Tribolium castaneum]>gi|158562480|gb|ABW74146.1| chitin deacetylase 4 [Tribolium castaneum]>gi|270005565|gb|EFA02013.1| hypothetical protein TcasGA2_TC007635 [Tribolium castaneum] 645033089 XM_001607939.3 188 3.07641e-91 PREDICTED: Nasonia vitripennis uncharacterized LOC100123586 (LOC100123586), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0005975//GO:0006807//GO:0006030 carbohydrate metabolic process//nitrogen compound metabolic process//chitin metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.28369 BP_3 1.00 21.77 224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28370 BP_3 17.70 2.88 588 546685505 ERL95003.1 282 7.6e-23 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836 RasGAP C-terminus GO:0007264 small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.28371 BP_3 31.30 5.40 571 546685505 ERL95003.1 252 2.2e-19 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836 RasGAP C-terminus GO:0007264 small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.28372 BP_3 39.53 4.46 719 546685504 ERL95002.1 335 6.7e-29 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836 RasGAP C-terminus GO:0007264 small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.28374 BP_3 388.76 4.04 4926 642912875 XP_008201292.1 4481 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X9 [Tribolium castaneum]>gi|270001881|gb|EEZ98328.1| hypothetical protein TcasGA2_TC000782 [Tribolium castaneum] 642912874 XM_008203070.1 1049 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1713 3.1e-189 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00781//PF00076//PF00130//PF00788//PF00609//PF07649 Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain//Diacylglycerol kinase accessory domain//C1-like domain GO:0046486//GO:0035556//GO:0055114//GO:0007205//GO:0009395//GO:0007165 glycerolipid metabolic process//intracellular signal transduction//oxidation-reduction process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//signal transduction GO:0003676//GO:0016301//GO:0000166//GO:0047134//GO:0046872//GO:0004143 nucleic acid binding//kinase activity//nucleotide binding//protein-disulfide reductase activity//metal ion binding//diacylglycerol kinase activity GO:0005622 intracellular KOG1169 Diacylglycerol kinase Cluster-8309.28375 BP_3 120.00 1.85 3412 91082935 XP_973029.1 2245 1.1e-249 PREDICTED: probable G-protein coupled receptor 158 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BBQ2 593 1.6e-59 Probable G-protein coupled receptor 158 OS=Bos taurus GN=GPR158 PE=3 SV=2 PF03188//PF11057//PF00003//PF06070//PF02780 Eukaryotic cytochrome b561//Cortexin of kidney//7 transmembrane sweet-taste receptor of 3 GCPR//Herpesvirus large structural phosphoprotein UL32//Transketolase, C-terminal domain GO:0007186//GO:0008152 G-protein coupled receptor signaling pathway//metabolic process GO:0003824//GO:0004930//GO:0005198 catalytic activity//G-protein coupled receptor activity//structural molecule activity GO:0016021//GO:0031224 integral component of membrane//intrinsic component of membrane KOG4418 Predicted membrane protein Cluster-8309.28376 BP_3 2.97 0.88 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28377 BP_3 29.00 0.66 2416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28378 BP_3 59175.00 2784.63 1316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28379 BP_3 2.00 2.24 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28381 BP_3 82.58 0.89 4776 642928567 XP_008199961.1 759 3.0e-77 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 580 7.1e-58 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067//PF09520//PF05316 Cytochrome P450//Type II restriction endonuclease, TdeIII//Mitochondrial ribosomal protein (VAR1) GO:0006412//GO:0055114//GO:0006308//GO:0042254//GO:0009307 translation//oxidation-reduction process//DNA catabolic process//ribosome biogenesis//DNA restriction-modification system GO:0016705//GO:0003677//GO:0009036//GO:0020037//GO:0005506//GO:0003735 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//DNA binding//Type II site-specific deoxyribonuclease activity//heme binding//iron ion binding//structural constituent of ribosome GO:0009359//GO:0005840//GO:0005761 Type II site-specific deoxyribonuclease complex//ribosome//mitochondrial ribosome -- -- Cluster-8309.28385 BP_3 26.00 2.34 828 642927254 XP_008195196.1 383 2.1e-34 PREDICTED: protein ACN9 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SZ16 295 1.4e-25 Succinate dehydrogenase assembly factor 3, mitochondrial OS=Drosophila melanogaster GN=Sdhaf3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4100 Uncharacterized conserved protein Cluster-8309.28386 BP_3 17.75 1.20 1002 288860140 NP_001165842.1 638 6.8e-64 uracil-DNA degrading factor [Tribolium castaneum]>gi|270002992|gb|EEZ99439.1| hypothetical protein TcasGA2_TC030651 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28388 BP_3 97.98 1.20 4239 642934439 XP_008197663.1 2147 3.0e-238 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 642934440 XM_008199442.1 78 8.40762e-30 PREDICTED: Tribolium castaneum nucleosome-remodeling factor subunit NURF301 (LOC100141790), transcript variant X3, mRNA K11728 BPTF, E(bx) nucleosome-remodeling factor subunit BPTF http://www.genome.jp/dbget-bin/www_bget?ko:K11728 Q9W0T1 685 4.2e-70 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG1473 Nucleosome remodeling factor, subunit NURF301/BPTF Cluster-8309.2839 BP_3 3.00 0.37 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28390 BP_3 402.51 2.92 6941 549438529 AGX25153.1 1932 4.2e-213 sulfhydryl oxidase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- O61491 815 5.8e-85 Flotillin-1 OS=Drosophila melanogaster GN=Flo-1 PE=2 SV=1 PF01743//PF00085//PF04777 Poly A polymerase head domain//Thioredoxin//Erv1 / Alr family GO:0006396//GO:0055114//GO:0045454 RNA processing//oxidation-reduction process//cell redox homeostasis GO:0003723//GO:0016972//GO:0016779 RNA binding//thiol oxidase activity//nucleotidyltransferase activity -- -- KOG1731 FAD-dependent sulfhydryl oxidase/quiescin and related proteins Cluster-8309.28393 BP_3 19.44 0.98 1245 91077058 XP_968505.1 1132 4.4e-121 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0V7M0 929 6.3e-99 Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1 PF02985//PF16006//PF01749//PF00514 HEAT repeat//Nucleolar and spindle-associated protein//Importin beta binding domain//Armadillo/beta-catenin-like repeat GO:0040001//GO:0015031//GO:0000281//GO:0000226//GO:0006606 establishment of mitotic spindle localization//protein transport//mitotic cytokinesis//microtubule cytoskeleton organization//protein import into nucleus GO:0005515//GO:0008565 protein binding//protein transporter activity GO:0005874//GO:0005634//GO:0005737//GO:0005819 microtubule//nucleus//cytoplasm//spindle KOG0166 Karyopherin (importin) alpha Cluster-8309.28394 BP_3 149.74 0.71 10524 91088841 XP_970807.1 2162 1.4e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.65015e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 6.1e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF01853//PF00538//PF00628//PF13508//PF01160//PF06431 MOZ/SAS family//linker histone H1 and H5 family//PHD-finger//Acetyltransferase (GNAT) domain//Vertebrate endogenous opioids neuropeptide//Polyomavirus large T antigen C-terminus GO:0042967//GO:0006334//GO:0006260//GO:0007218//GO:0006355 acyl-carrier-protein biosynthetic process//nucleosome assembly//DNA replication//neuropeptide signaling pathway//regulation of transcription, DNA-templated GO:0005515//GO:0008080//GO:0003677//GO:0005524//GO:0016747//GO:0005488 protein binding//N-acetyltransferase activity//DNA binding//ATP binding//transferase activity, transferring acyl groups other than amino-acyl groups//binding GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.28396 BP_3 25.42 0.95 1579 195470156 XP_002087374.1 190 9.5e-12 GE16582 [Drosophila yakuba]>gi|194173475|gb|EDW87086.1| GE16582 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- P18298 145 6.5e-08 S-adenosylmethionine synthase isoform type-2 OS=Rattus norvegicus GN=Mat2a PE=1 SV=1 -- -- GO:0006556//GO:0006730//GO:0015948//GO:0006555 S-adenosylmethionine biosynthetic process//one-carbon metabolic process//methanogenesis//methionine metabolic process GO:0004478//GO:0005524//GO:0046872 methionine adenosyltransferase activity//ATP binding//metal ion binding -- -- KOG1506 S-adenosylmethionine synthetase Cluster-8309.28397 BP_3 2323.07 44.87 2787 642926864 XP_008195044.1 2346 1.7e-261 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum] 748585115 LC002996.1 39 2.63381e-08 Ostrinia furnacalis gene for hypothetical protein, partial cds, note: entry16 -- -- -- -- O18824 615 3.6e-62 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.28398 BP_3 4.00 1.67 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2840 BP_3 222.00 70.50 443 91091646 XP_970895.1 282 5.7e-23 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000889|gb|EEZ97336.1| hypothetical protein TcasGA2_TC011148 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 200 7.6e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.28400 BP_3 256.26 6.26 2266 270006529 EFA02977.1 1090 6.0e-116 hypothetical protein TcasGA2_TC030780 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O77649 291 1.1e-24 UDP-glucuronosyltransferase 2B20 OS=Macaca fascicularis GN=UGT2B20 PE=1 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.28401 BP_3 350.60 2.59 6824 546681968 ERL91964.1 676 1.8e-67 hypothetical protein D910_09287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 139 1.4e-06 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF09472//PF04838 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Baculoviridae late expression factor 5 GO:0046656//GO:0015948//GO:0006355 folic acid biosynthetic process//methanogenesis//regulation of transcription, DNA-templated GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane -- -- Cluster-8309.28402 BP_3 9.89 1.30 657 549438545 AGX25161.1 143 1.1e-06 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28403 BP_3 571.62 10.09 3021 270014969 EFA11417.1 3432 0.0e+00 hypothetical protein TcasGA2_TC013593 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1262 3.7e-137 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF00103//PF08123//PF02390 Somatotropin hormone family//Histone methylation protein DOT1//Putative methyltransferase GO:0007165//GO:0009451//GO:0006479//GO:0006400//GO:0008033//GO:0006554 signal transduction//RNA modification//protein methylation//tRNA modification//tRNA processing//lysine catabolic process GO:0018024//GO:0005179//GO:0008176 histone-lysine N-methyltransferase activity//hormone activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.28404 BP_3 225.00 21.29 801 642917175 XP_008191150.1 821 3.3e-85 PREDICTED: pangolin isoform X2 [Tribolium castaneum] 642917174 XM_008192928.1 309 5.94277e-159 PREDICTED: Tribolium castaneum pangolin (Pan), transcript variant X2, mRNA K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 P91943 438 3.5e-42 Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28406 BP_3 76.51 0.83 4719 642932794 XP_974082.2 1528 2.0e-166 PREDICTED: dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [Tribolium castaneum] 755973707 XM_011308799.1 131 3.22924e-59 PREDICTED: Fopius arisanus dual specificity mitogen-activated protein kinase kinase 4-like (LOC105268902), mRNA K04430 MAP2K4, MKK4 mitogen-activated protein kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04430 P47809 1129 1.5e-121 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 PF04196//PF00069//PF07714 Bunyavirus RNA dependent RNA polymerase//Protein kinase domain//Protein tyrosine kinase GO:0006351//GO:0019079//GO:0006468//GO:0006144 transcription, DNA-templated//viral genome replication//protein phosphorylation//purine nucleobase metabolic process GO:0005524//GO:0003968//GO:0004672 ATP binding//RNA-directed RNA polymerase activity//protein kinase activity GO:0031379 RNA-directed RNA polymerase complex KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4 Cluster-8309.28407 BP_3 595.73 9.22 3405 91078826 XP_971080.1 2362 2.9e-263 PREDICTED: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [Tribolium castaneum]>gi|270003721|gb|EFA00169.1| hypothetical protein TcasGA2_TC002991 [Tribolium castaneum] 347970839 XM_308110.5 56 1.14379e-17 Anopheles gambiae str. PEST AGAP003884-PA (AgaP_AGAP003884) mRNA, complete cds K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 Q9UKM7 1389 7.9e-152 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Homo sapiens GN=MAN1B1 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2431 1, 2-alpha-mannosidase Cluster-8309.28408 BP_3 169.00 15.33 823 332376336 AEE63308.1 495 2.1e-47 unknown [Dendroctonus ponderosae]>gi|478250761|gb|ENN71253.1| hypothetical protein YQE_12180, partial [Dendroctonus ponderosae]>gi|546671401|gb|ERL83726.1| hypothetical protein D910_00939 [Dendroctonus ponderosae]>gi|546673039|gb|ERL84725.1| hypothetical protein D910_02150 [Dendroctonus ponderosae]>gi|546675545|gb|ERL86718.1| hypothetical protein D910_04124 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y6G5 212 5.7e-16 COMM domain-containing protein 10 OS=Homo sapiens GN=COMMD10 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28409 BP_3 674.00 32.25 1299 123445779 XP_001311646.1 205 1.4e-13 hypothetical protein [Trichomonas vaginalis G3]>gi|121893464|gb|EAX98716.1| hypothetical protein TVAG_480920 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54J55 170 6.7e-11 Myb-like protein X OS=Dictyostelium discoideum GN=mybX PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2841 BP_3 7.00 0.40 1132 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28413 BP_3 86.68 0.94 4740 642927044 XP_008195115.1 1565 1.0e-170 PREDICTED: LOW QUALITY PROTEIN: transmembrane protein 214-B [Tribolium castaneum] -- -- -- -- -- K03424 tatD TatD DNase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03424 Q148G4 699 1.1e-71 Putative deoxyribonuclease TATDN1 OS=Bos taurus GN=TATDN1 PE=2 SV=1 PF01026 TatD related DNase GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3020 TatD-related DNase Cluster-8309.28415 BP_3 264.82 9.19 1681 478251541 ENN72003.1 878 1.7e-91 hypothetical protein YQE_11294, partial [Dendroctonus ponderosae]>gi|546681207|gb|ERL91342.1| hypothetical protein D910_08674 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q98943 360 8.1e-33 Caspase-2 OS=Gallus gallus GN=CASP2 PE=2 SV=2 PF00656//PF02735//PF00619 Caspase domain//Ku70/Ku80 beta-barrel domain//Caspase recruitment domain GO:0006303//GO:0042981//GO:0006508 double-strand break repair via nonhomologous end joining//regulation of apoptotic process//proteolysis GO:0004197//GO:0003677 cysteine-type endopeptidase activity//DNA binding -- -- KOG3573 Caspase, apoptotic cysteine protease Cluster-8309.28417 BP_3 3869.29 29.11 6698 642934517 XP_008197696.1 5483 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein Mi-2 homolog isoform X1 [Tribolium castaneum]>gi|270013510|gb|EFA09958.1| hypothetical protein TcasGA2_TC012115 [Tribolium castaneum] 815926192 XM_012392264.1 601 0 PREDICTED: Bombus impatiens chromodomain-helicase-DNA-binding protein Mi-2 homolog (LOC100740721), transcript variant X10, mRNA K11643 CHD4, MI2B chromodomain-helicase-DNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11643 O97159 4696 0.0e+00 Chromodomain-helicase-DNA-binding protein Mi-2 homolog OS=Drosophila melanogaster GN=Mi-2 PE=1 SV=2 PF08074//PF00270//PF04851//PF00641//PF00176//PF08073//PF00130//PF00628//PF00001//PF06357 CHDCT2 (NUC038) domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//Zn-finger in Ran binding protein and others//SNF2 family N-terminal domain//CHDNT (NUC034) domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//7 transmembrane receptor (rhodopsin family)//Omega-atracotoxin GO:0006952//GO:0006810//GO:0009405//GO:0035556//GO:0006355//GO:0007186 defense response//transport//pathogenesis//intracellular signal transduction//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway GO:0005524//GO:0016787//GO:0019855//GO:0016818//GO:0008270//GO:0005515//GO:0004386//GO:0004930//GO:0003677//GO:0043169//GO:0003676 ATP binding//hydrolase activity//calcium channel inhibitor activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//protein binding//helicase activity//G-protein coupled receptor activity//DNA binding//cation binding//nucleic acid binding GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG0383 Predicted helicase Cluster-8309.28420 BP_3 324.00 9.63 1913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02740 Colipase, C-terminal domain GO:0016042//GO:0007586 lipid catabolic process//digestion GO:0008047 enzyme activator activity GO:0005576 extracellular region -- -- Cluster-8309.28423 BP_3 30.35 2.03 1012 189235321 XP_975176.2 857 2.8e-89 PREDICTED: methyltransferase-like protein 22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUU2 221 6.4e-17 Methyltransferase-like protein 22 OS=Homo sapiens GN=METTL22 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28424 BP_3 9.84 0.53 1179 646705170 KDR13037.1 288 3.1e-23 hypothetical protein L798_13305 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W3T5 273 6.9e-23 Small integral membrane protein 4 OS=Drosophila melanogaster GN=CG32736 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28426 BP_3 1137.03 37.63 1748 642914052 XP_969243.3 1720 4.1e-189 PREDICTED: sorting nexin-6 isoform X2 [Tribolium castaneum]>gi|270001606|gb|EEZ98053.1| hypothetical protein TcasGA2_TC000458 [Tribolium castaneum] 697469095 XM_009669926.1 81 7.36744e-32 PREDICTED: Struthio camelus australis sorting nexin 6 (SNX6), transcript variant X2, mRNA K17920 SNX5_6_32 sorting nexin-5/6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K17920 Q5R613 1053 3.7e-113 Sorting nexin-6 OS=Pongo abelii GN=SNX6 PE=2 SV=1 PF04632//PF00787 Fusaric acid resistance protein family//PX domain GO:0007154//GO:0006810 cell communication//transport GO:0035091 phosphatidylinositol binding GO:0005886 plasma membrane KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.28428 BP_3 461.22 13.37 1955 189237918 XP_001811805.1 2173 1.3e-241 PREDICTED: transcription initiation factor TFIID subunit 6 [Tribolium castaneum]>gi|270006675|gb|EFA03123.1| hypothetical protein TcasGA2_TC013033 [Tribolium castaneum] 762091727 XM_011429969.1 66 1.80017e-23 PREDICTED: Crassostrea gigas transcription initiation factor TFIID subunit 6-like (LOC105328924), mRNA K03131 TAF6 transcription initiation factor TFIID subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03131 P49847 1567 1.0e-172 Transcription initiation factor TFIID subunit 6 OS=Drosophila melanogaster GN=Taf6 PE=1 SV=2 PF02969//PF07571//PF08769//PF00125 TATA box binding protein associated factor (TAF)//TAF6 C-terminal HEAT repeat domain//Sporulation initiation factor Spo0A C terminal//Core histone H2A/H2B/H3/H4 GO:0006355//GO:0042173//GO:0006352//GO:0051090 regulation of transcription, DNA-templated//regulation of sporulation resulting in formation of a cellular spore//DNA-templated transcription, initiation//regulation of sequence-specific DNA binding transcription factor activity GO:0005509//GO:0003700//GO:0003677//GO:0046982 calcium ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding//protein heterodimerization activity GO:0005737//GO:0005634//GO:0005667 cytoplasm//nucleus//transcription factor complex KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.28429 BP_3 5.61 0.37 1024 546681137 ERL91287.1 264 1.6e-20 hypothetical protein D910_08620 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28430 BP_3 24.00 3.73 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28431 BP_3 662.01 4.00 8271 270002738 EEZ99185.1 1670 1.2e-182 serine protease H6 [Tribolium castaneum] 462358611 APGK01030035.1 93 7.55325e-38 Dendroctonus ponderosae Seq01030045, whole genome shotgun sequence -- -- -- -- E1BLP6 751 1.8e-77 AT-rich interactive domain-containing protein 5B OS=Bos taurus GN=ARID5B PE=3 SV=1 PF06090//PF04926//PF01388 Inositol-pentakisphosphate 2-kinase//Poly(A) polymerase predicted RNA binding domain//ARID/BRIGHT DNA binding domain GO:0043631 RNA polyadenylation GO:0003723//GO:0005524//GO:0003677//GO:0035299 RNA binding//ATP binding//DNA binding//inositol pentakisphosphate 2-kinase activity -- -- KOG2744 DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain Cluster-8309.28433 BP_3 226.50 19.01 866 642912857 XP_008201282.1 795 3.7e-82 PREDICTED: AP-1 complex subunit sigma-2 isoform X2 [Tribolium castaneum] 642912856 XM_008203060.1 207 3.24194e-102 PREDICTED: Tribolium castaneum AP-1 complex subunit sigma-2 (LOC659702), transcript variant X2, mRNA K12394 AP1S1_2 AP-1 complex subunit sigma 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12394 Q3ZBS3 673 2.1e-69 AP-1 complex subunit sigma-2 OS=Bos taurus GN=AP1S2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0934 Clathrin adaptor complex, small subunit Cluster-8309.28434 BP_3 691.48 3.37 10191 -- -- -- -- -- 642912856 XM_008203060.1 43 5.80774e-10 PREDICTED: Tribolium castaneum AP-1 complex subunit sigma-2 (LOC659702), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28435 BP_3 14.00 0.91 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28436 BP_3 6.00 0.81 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28437 BP_3 1307.77 30.39 2366 189235165 XP_968097.2 1371 1.6e-148 PREDICTED: RNA polymerase-associated protein Rtf1 [Tribolium castaneum] -- -- -- -- -- K15178 RTF1 RNA polymerase-associated protein RTF1 http://www.genome.jp/dbget-bin/www_bget?ko:K15178 Q9W261 946 1.3e-100 RNA polymerase-associated protein Rtf1 OS=Drosophila melanogaster GN=Rtf1 PE=1 SV=1 PF03126 Plus-3 domain -- -- GO:0003677 DNA binding -- -- KOG2402 Paf1/RNA polymerase II complex, RTF1 component (involved in regulation of TATA box-binding protein) Cluster-8309.28438 BP_3 7.00 14.15 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28439 BP_3 219.08 3.81 3065 91092584 XP_969806.1 1985 1.3e-219 PREDICTED: F-box only protein 42 [Tribolium castaneum] 642921791 XM_964713.2 183 2.58961e-88 PREDICTED: Tribolium castaneum F-box only protein 42 (LOC658311), mRNA K10317 FBXO42 F-box protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K10317 Q6PDJ6 755 2.3e-78 F-box only protein 42 OS=Mus musculus GN=Fbxo42 PE=2 SV=1 PF12937//PF01344//PF07646//PF00646 F-box-like//Kelch motif//Kelch motif//F-box domain -- -- GO:0005515 protein binding -- -- KOG0379 Kelch repeat-containing proteins Cluster-8309.2844 BP_3 6.00 0.91 610 827547769 XP_012546165.1 197 5.7e-13 PREDICTED: uncharacterized protein LOC101737154 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01388//PF08707 ARID/BRIGHT DNA binding domain//Primase C terminal 2 (PriCT-2) -- -- GO:0003677//GO:0016817 DNA binding//hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.28441 BP_3 501.92 11.32 2429 189236145 XP_974763.2 2325 4.0e-259 PREDICTED: diphthine--ammonia ligase [Tribolium castaneum]>gi|270005602|gb|EFA02050.1| hypothetical protein TcasGA2_TC007678 [Tribolium castaneum] -- -- -- -- -- K06927 DPH6 diphthine-ammonia ligase http://www.genome.jp/dbget-bin/www_bget?ko:K06927 Q9USQ7 917 3.0e-97 Diphthine--ammonia ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mug71 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2316 Predicted ATPase (PP-loop superfamily) Cluster-8309.28442 BP_3 162.51 0.66 12139 546678376 ERL89009.1 14883 0.0e+00 hypothetical protein D910_06387 [Dendroctonus ponderosae] 861437320 XM_013072408.1 160 6.31372e-75 PREDICTED: Heterocephalus glaber dynein, axonemal, heavy chain 5 (Dnah5), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q96JB1 10648 0.0e+00 Dynein heavy chain 8, axonemal OS=Homo sapiens GN=DNAH8 PE=1 SV=2 PF11112//PF09520//PF07728//PF00910//PF00004//PF03028 Pyocin activator protein PrtN//Type II restriction endonuclease, TdeIII//AAA domain (dynein-related subfamily)//RNA helicase//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor GO:0007017//GO:0006355//GO:0009307//GO:0006308//GO:0007018 microtubule-based process//regulation of transcription, DNA-templated//DNA restriction-modification system//DNA catabolic process//microtubule-based movement GO:0016887//GO:0003724//GO:0005524//GO:0003723//GO:0003677//GO:0009036//GO:0003777 ATPase activity//RNA helicase activity//ATP binding//RNA binding//DNA binding//Type II site-specific deoxyribonuclease activity//microtubule motor activity GO:0009359//GO:0030286//GO:0005874 Type II site-specific deoxyribonuclease complex//dynein complex//microtubule -- -- Cluster-8309.28444 BP_3 7.35 0.31 1438 642929416 XP_008195830.1 398 6.6e-36 PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929418|ref|XP_008195831.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929420|ref|XP_008195832.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI6 267 4.2e-22 Transcription factor CP2-like protein 1 OS=Homo sapiens GN=TFCP2L1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.28446 BP_3 168.00 10.04 1098 91077690 XP_974728.1 1017 8.4e-108 PREDICTED: transcriptional adapter 1 [Tribolium castaneum]>gi|270001530|gb|EEZ97977.1| hypothetical protein TcasGA2_TC000372 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99LM9 254 1.0e-20 Transcriptional adapter 1 OS=Mus musculus GN=Tada1 PE=2 SV=1 PF12767//PF05236 Transcriptional regulator of RNA polII, SAGA, subunit//Transcription initiation factor TFIID component TAF4 family GO:0006352 DNA-templated transcription, initiation -- -- GO:0070461//GO:0005669 SAGA-type complex//transcription factor TFIID complex -- -- Cluster-8309.28447 BP_3 98.00 3.24 1750 642918336 XP_008196857.1 262 4.7e-20 PREDICTED: serine/threonine-protein kinase tricorner [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28449 BP_3 62.18 1.98 1802 478254833 ENN75069.1 881 8.1e-92 hypothetical protein YQE_08382, partial [Dendroctonus ponderosae] -- -- -- -- -- K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P85973 738 1.3e-76 Purine nucleoside phosphorylase OS=Rattus norvegicus GN=Pnp PE=1 SV=1 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-8309.28450 BP_3 60.02 0.55 5521 642911714 XP_008200711.1 682 3.0e-68 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 557 3.8e-55 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF01118//PF09339 short chain dehydrogenase//Semialdehyde dehydrogenase, NAD binding domain//IclR helix-turn-helix domain GO:0006355//GO:0008152//GO:0055114 regulation of transcription, DNA-templated//metabolic process//oxidation-reduction process GO:0003677//GO:0051287//GO:0016491//GO:0016620 DNA binding//NAD binding//oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.28451 BP_3 16.86 0.50 1915 478258090 ENN78228.1 907 8.4e-95 hypothetical protein YQE_05379, partial [Dendroctonus ponderosae] -- -- -- -- -- K08271 STRADA, LYK5 STE20-related kinase adapter protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08271 Q5ZK47 444 1.7e-42 STE20-related kinase adapter protein alpha OS=Gallus gallus GN=STRADA PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0582 Ste20-like serine/threonine protein kinase Cluster-8309.28452 BP_3 28.47 0.34 4349 270011364 EFA07812.1 378 4.2e-33 hypothetical protein TcasGA2_TC005373 [Tribolium castaneum] -- -- -- -- -- K12811 DDX46, PRP5 ATP-dependent RNA helicase DDX46/PRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K12811 Q7L014 269 7.5e-22 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens GN=DDX46 PE=1 SV=2 PF12179 I-kappa-kinase-beta NEMO binding domain GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0008384 IkappaB kinase activity GO:0008385 IkappaB kinase complex KOG0334 RNA helicase Cluster-8309.28453 BP_3 319.10 2.40 6709 270001519 EEZ97966.1 3745 0.0e+00 hypothetical protein TcasGA2_TC000358 [Tribolium castaneum] 462381540 APGK01021978.1 59 4.86715e-19 Dendroctonus ponderosae Seq01021988, whole genome shotgun sequence K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 1088 1.2e-116 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF04111//PF10473//PF16331//PF11365 Autophagy protein Apg6//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TolA binding protein trimerisation//Protein of unknown function (DUF3166) GO:0006914//GO:0070206//GO:0010506 autophagy//protein trimerization//regulation of autophagy GO:0042803//GO:0045502//GO:0008134 protein homodimerization activity//dynein binding//transcription factor binding GO:0005615//GO:0005667//GO:0030286 extracellular space//transcription factor complex//dynein complex -- -- Cluster-8309.28455 BP_3 100.24 0.95 5360 642918446 XP_008191478.1 2992 0.0e+00 PREDICTED: protein zer-1 homolog [Tribolium castaneum]>gi|270003243|gb|EEZ99690.1| hypothetical protein TcasGA2_TC002447 [Tribolium castaneum] 826411946 XM_012687571.1 108 2.24101e-46 PREDICTED: Monomorium pharaonis TBC1 domain family member 13 (LOC105840594), transcript variant X2, mRNA K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q9W0E8 1706 2.2e-188 Protein zer-1 homolog OS=Drosophila melanogaster GN=CG12084 PE=2 SV=2 PF00560//PF13855//PF00514 Leucine Rich Repeat//Leucine rich repeat//Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- KOG4567 GTPase-activating protein Cluster-8309.28456 BP_3 10.00 1.80 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28457 BP_3 308.00 68.59 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28459 BP_3 4.00 2.48 366 -- -- -- -- -- 462282290 APGK01057357.1 43 1.90704e-11 Dendroctonus ponderosae Seq01057367, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2846 BP_3 1.00 0.79 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28461 BP_3 10.31 0.53 1233 642938308 XP_008192812.1 431 8.4e-40 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X4 [Tribolium castaneum] 642938313 XM_008194605.1 103 3.03587e-44 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X8, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28462 BP_3 1064.34 6.07 8741 270014238 EFA10686.1 640 3.5e-63 Syntaxin 1A [Tribolium castaneum] 820846584 XM_012485784.1 129 7.76162e-58 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X4, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 565 7.1e-56 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF15898//PF04136//PF04799//PF01499//PF09003//PF05739//PF09177//PF00804//PF11744//PF00443//PF04632//PF05478//PF02485//PF07851//PF04111 cGMP-dependent protein kinase interacting domain//Sec34-like family//fzo-like conserved region//Herpesvirus UL25 family//Bacteriophage lambda integrase, N-terminal domain//SNARE domain//Syntaxin 6, N-terminal//Syntaxin//Aluminium activated malate transporter//Ubiquitin carboxyl-terminal hydrolase//Fusaric acid resistance protein family//Prominin//Core-2/I-Branching enzyme//TMPIT-like protein//Autophagy protein Apg6 GO:0006886//GO:0006810//GO:0006914//GO:0019072//GO:0016579//GO:0048193//GO:0015743//GO:0015074//GO:0008053 intracellular protein transport//transport//autophagy//viral genome packaging//protein deubiquitination//Golgi vesicle transport//malate transport//DNA integration//mitochondrial fusion GO:0003924//GO:0008375//GO:0036459//GO:0019901//GO:0005515//GO:0003677//GO:0008907 GTPase activity//acetylglucosaminyltransferase activity//ubiquitinyl hydrolase activity//protein kinase binding//protein binding//DNA binding//integrase activity GO:0042025//GO:0016021//GO:0005801//GO:0005886//GO:0016020//GO:0005741 host cell nucleus//integral component of membrane//cis-Golgi network//plasma membrane//membrane//mitochondrial outer membrane KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.28463 BP_3 10.47 0.74 976 270010211 EFA06659.1 300 1.0e-24 hypothetical protein TcasGA2_TC009585 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28464 BP_3 710.14 5.29 6760 642916006 XP_008190854.1 2795 0.0e+00 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96923 134 5.2e-06 Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum GN=gnrA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28468 BP_3 136.45 2.36 3079 642915313 XP_008190567.1 874 9.0e-91 PREDICTED: dosage compensation regulator isoform X1 [Tribolium castaneum] 765148185 XM_011486434.1 95 2.15858e-39 PREDICTED: Oryzias latipes DEAH (Asp-Glu-Ala-His) box helicase 9 (dhx9), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 736 3.7e-76 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF03060//PF00270//PF00437//PF03368 Nitronate monooxygenase//DEAD/DEAH box helicase//Type II/IV secretion system protein//Dicer dimerisation domain GO:0051252//GO:0006807//GO:0055114//GO:0006810 regulation of RNA metabolic process//nitrogen compound metabolic process//oxidation-reduction process//transport GO:0016891//GO:0003676//GO:0018580//GO:0005524 endoribonuclease activity, producing 5'-phosphomonoesters//nucleic acid binding//nitronate monooxygenase activity//ATP binding -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.28469 BP_3 612.62 17.91 1940 270003897 EFA00345.1 2375 5.1e-265 hypothetical protein TcasGA2_TC003184 [Tribolium castaneum] 766920220 XM_011506269.1 107 2.88492e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1725 4.9e-191 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF00270//PF00437//PF03060//PF03368 DEAD/DEAH box helicase//Type II/IV secretion system protein//Nitronate monooxygenase//Dicer dimerisation domain GO:0006810//GO:0006807//GO:0055114//GO:0051252 transport//nitrogen compound metabolic process//oxidation-reduction process//regulation of RNA metabolic process GO:0018580//GO:0005524//GO:0016891//GO:0003676 nitronate monooxygenase activity//ATP binding//endoribonuclease activity, producing 5'-phosphomonoesters//nucleic acid binding -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.2847 BP_3 6.00 1.09 556 -- -- -- -- -- 768311752 CP010980.1 509 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28471 BP_3 804.96 13.09 3255 91082551 XP_973940.1 2212 6.8e-246 PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|642922810|ref|XP_008193334.1| PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|642922812|ref|XP_008193335.1| PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|270007563|gb|EFA04011.1| hypothetical protein TcasGA2_TC014160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83097 782 1.8e-81 Putative tyrosine-protein kinase Wsck OS=Drosophila melanogaster GN=Wsck PE=2 SV=2 PF00069//PF07714//PF00041 Protein kinase domain//Protein tyrosine kinase//Fibronectin type III domain GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.28472 BP_3 201.11 0.87 11384 642923391 XP_008193728.1 8407 0.0e+00 PREDICTED: protein still life, isoform SIF type 1 [Tribolium castaneum] 642923390 XM_008195506.1 1824 0 PREDICTED: Tribolium castaneum protein still life, isoform SIF type 1 (LOC662876), mRNA -- -- -- -- P91621 6459 0.0e+00 Protein still life, isoform SIF type 1 OS=Drosophila melanogaster GN=sif PE=2 SV=2 PF00595//PF00621//PF02724//PF13180//PF02196//PF05453 PDZ domain (Also known as DHR or GLGF)//RhoGEF domain//CDC45-like protein//PDZ domain//Raf-like Ras-binding domain//BmTXKS1/BmP02 toxin family GO:0035023//GO:0007165//GO:0009405//GO:0006270//GO:0006810//GO:0043087 regulation of Rho protein signal transduction//signal transduction//pathogenesis//DNA replication initiation//transport//regulation of GTPase activity GO:0008200//GO:0005057//GO:0005515//GO:0005089 ion channel inhibitor activity//receptor signaling protein activity//protein binding//Rho guanyl-nucleotide exchange factor activity GO:0005576 extracellular region KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases Cluster-8309.28474 BP_3 236.67 3.99 3152 91085411 XP_967521.1 2281 6.5e-254 PREDICTED: protein Malvolio isoform X1 [Tribolium castaneum]>gi|270008404|gb|EFA04852.1| hypothetical protein TcasGA2_TC014904 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1804 5.5e-200 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF01566//PF08089//PF15168 Natural resistance-associated macrophage protein//Huwentoxin-II family//Triple QxxK/R motif-containing protein family GO:0009405//GO:0006810 pathogenesis//transport GO:0005215 transporter activity GO:0016020//GO:0005789//GO:0005576 membrane//endoplasmic reticulum membrane//extracellular region KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.28476 BP_3 1601.41 25.49 3320 91085411 XP_967521.1 2312 1.7e-257 PREDICTED: protein Malvolio isoform X1 [Tribolium castaneum]>gi|270008404|gb|EFA04852.1| hypothetical protein TcasGA2_TC014904 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1804 5.8e-200 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF08089//PF15168//PF01566 Huwentoxin-II family//Triple QxxK/R motif-containing protein family//Natural resistance-associated macrophage protein GO:0009405//GO:0006810 pathogenesis//transport GO:0005215 transporter activity GO:0005789//GO:0016020//GO:0005576 endoplasmic reticulum membrane//membrane//extracellular region KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.28477 BP_3 5.41 0.40 946 642926735 XP_008194991.1 556 2.1e-54 PREDICTED: protein Malvolio isoform X3 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 527 2.0e-52 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF11808//PF01566 Domain of unknown function (DUF3329)//Natural resistance-associated macrophage protein GO:0006810//GO:0016310 transport//phosphorylation GO:0004673//GO:0005215 protein histidine kinase activity//transporter activity GO:0016020//GO:0009365 membrane//protein histidine kinase complex KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.28478 BP_3 46.00 2.91 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2848 BP_3 14.00 1.19 860 -- -- -- -- -- 768311752 CP010980.1 377 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28481 BP_3 77.70 3.37 1404 642937410 XP_008198824.1 862 1.0e-89 PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|642937412|ref|XP_008198826.1| PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|270000810|gb|EEZ97257.1| hypothetical protein TcasGA2_TC011057 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 380 3.2e-35 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0008152//GO:0008654//GO:0046486//GO:0042967 metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.28482 BP_3 579.95 50.80 842 642923289 XP_008193692.1 459 3.3e-43 PREDICTED: uncharacterized protein LOC103313098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28484 BP_3 4.00 0.93 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28486 BP_3 87.97 5.89 1012 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28487 BP_3 166.27 3.91 2341 642924686 XP_008194398.1 2217 1.3e-246 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD5 734 4.8e-76 Mitochondrial sodium/hydrogen exchanger 9B2 OS=Homo sapiens GN=SLC9B2 PE=1 SV=2 PF00999//PF07086 Sodium/hydrogen exchanger family//Jagunal, ER re-organisation during oogenesis GO:0006885//GO:0055085//GO:0006812//GO:0007029 regulation of pH//transmembrane transport//cation transport//endoplasmic reticulum organization GO:0015299 solute:proton antiporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG3826 Na+/H+ antiporter Cluster-8309.28488 BP_3 2.37 0.34 633 478251401 ENN71867.1 278 2.4e-22 hypothetical protein YQE_11482, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28489 BP_3 36.71 1.81 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2849 BP_3 652.00 7.72 4363 642930054 XP_008196230.1 1627 6.2e-178 PREDICTED: uncharacterized protein LOC662737 [Tribolium castaneum] 642930053 XM_008198008.1 161 6.27848e-76 PREDICTED: Tribolium castaneum uncharacterized LOC662737 (LOC662737), mRNA -- -- -- -- Q05319 619 1.9e-62 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089//PF00856 Trypsin//SET domain GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.28490 BP_3 596.20 8.54 3657 478255072 ENN75302.1 3267 0.0e+00 hypothetical protein YQE_08079, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1260 7.7e-137 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.28491 BP_3 4.03 0.73 556 546684786 ERL94381.1 354 3.2e-31 hypothetical protein D910_11660 [Dendroctonus ponderosae] 414073107 JQ885989.1 96 1.03018e-40 Misgurnus anguillicaudatus HSC70 mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 350 3.9e-32 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.28492 BP_3 189.53 2.78 3572 91091508 XP_969167.1 1943 1.2e-214 PREDICTED: protein LMBR1L isoform X2 [Tribolium castaneum]>gi|270000933|gb|EEZ97380.1| hypothetical protein TcasGA2_TC011205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 905 1.1e-95 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.28493 BP_3 81.24 10.81 654 189241548 XP_971070.2 353 4.9e-31 PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|642936933|ref|XP_008194513.1| PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|270001278|gb|EEZ97725.1| spatzle 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28494 BP_3 42.82 0.90 2588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28495 BP_3 25.01 1.03 1459 642918268 XP_008191439.1 1176 4.1e-126 PREDICTED: methoprene-tolerant isoform X1 [Tribolium castaneum]>gi|207367000|dbj|BAG71980.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97460 221 9.2e-17 Neuronal PAS domain-containing protein 2 OS=Mus musculus GN=Npas2 PE=1 SV=1 PF00989//PF08447 PAS fold//PAS fold GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0046983//GO:0004871//GO:0003700 DNA binding//protein binding//protein dimerization activity//signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.28496 BP_3 90.97 1.65 2953 642914975 XP_008190466.1 1090 7.8e-116 PREDICTED: sialic acid synthase [Tribolium castaneum]>gi|270001379|gb|EEZ97826.1| hypothetical protein TcasGA2_TC000193 [Tribolium castaneum] -- -- -- -- -- K05304 NANS, SAS sialic acid synthase http://www.genome.jp/dbget-bin/www_bget?ko:K05304 Q9NR45 957 8.5e-102 Sialic acid synthase OS=Homo sapiens GN=NANS PE=1 SV=2 PF03102//PF03998 NeuB family//Utp11 protein GO:0016051//GO:0006364 carbohydrate biosynthetic process//rRNA processing -- -- GO:0032040 small-subunit processome KOG3237 Uncharacterized conserved protein Cluster-8309.28497 BP_3 1189.74 23.60 2722 642914975 XP_008190466.1 1090 7.2e-116 PREDICTED: sialic acid synthase [Tribolium castaneum]>gi|270001379|gb|EEZ97826.1| hypothetical protein TcasGA2_TC000193 [Tribolium castaneum] -- -- -- -- -- K05304 NANS, SAS sialic acid synthase http://www.genome.jp/dbget-bin/www_bget?ko:K05304 Q9NR45 957 7.8e-102 Sialic acid synthase OS=Homo sapiens GN=NANS PE=1 SV=2 PF03102//PF03998 NeuB family//Utp11 protein GO:0016051//GO:0006364 carbohydrate biosynthetic process//rRNA processing -- -- GO:0032040 small-subunit processome KOG3237 Uncharacterized conserved protein Cluster-8309.28500 BP_3 111.91 5.66 1245 642933391 XP_008197397.1 350 2.1e-30 PREDICTED: cyclin-dependent kinase 2-associated protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49119 216 3.0e-16 Cyclin-dependent kinase 2-associated protein 1 OS=Mesocricetus auratus GN=CDK2AP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4713 Cyclin-dependent kinase 2-associated protein Cluster-8309.28501 BP_3 510.69 9.48 2889 237681141 NP_001153713.1 2130 1.9e-236 glycerol kinase-like [Tribolium castaneum]>gi|270003063|gb|EEZ99510.1| hypothetical protein TcasGA2_TC000091 [Tribolium castaneum] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q14409 1486 3.8e-163 Putative glycerol kinase 3 OS=Homo sapiens GN=GK3P PE=5 SV=2 PF02782//PF00370 FGGY family of carbohydrate kinases, C-terminal domain//FGGY family of carbohydrate kinases, N-terminal domain GO:0006072//GO:0016310//GO:0005975//GO:0046486 glycerol-3-phosphate metabolic process//phosphorylation//carbohydrate metabolic process//glycerolipid metabolic process GO:0016773//GO:0004370 phosphotransferase activity, alcohol group as acceptor//glycerol kinase activity -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.28502 BP_3 15.18 0.42 2053 478256565 ENN76749.1 468 7.2e-44 hypothetical protein YQE_06814, partial [Dendroctonus ponderosae] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q4R4D5 335 7.8e-30 Glycerol kinase 2 OS=Macaca fascicularis GN=GK2 PE=2 SV=1 PF02782 FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.28503 BP_3 18.91 0.74 1516 91086851 XP_974311.1 638 1.0e-63 PREDICTED: vacuolar protein-sorting-associated protein 25 [Tribolium castaneum]>gi|270010461|gb|EFA06909.1| hypothetical protein TcasGA2_TC009858 [Tribolium castaneum] -- -- -- -- -- K12189 VPS25, EAP20 ESCRT-II complex subunit VPS25 http://www.genome.jp/dbget-bin/www_bget?ko:K12189 Q6NWF4 431 4.3e-41 Vacuolar protein-sorting-associated protein 25 OS=Danio rerio GN=vps25 PE=2 SV=2 PF07749 Endoplasmic reticulum protein ERp29, C-terminal domain -- -- -- -- GO:0005783 endoplasmic reticulum KOG4068 Uncharacterized conserved protein Cluster-8309.28505 BP_3 13.00 2.77 518 642938802 XP_008199892.1 355 2.3e-31 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- K09641 TMPRSS11D transmembrane protease, serine 11D http://www.genome.jp/dbget-bin/www_bget?ko:K09641 P05049 305 5.9e-27 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.28506 BP_3 899.00 11.54 4045 91086457 XP_969562.1 2035 2.8e-225 PREDICTED: vacuolar fusion protein MON1 homolog A [Tribolium castaneum]>gi|270009814|gb|EFA06262.1| hypothetical protein TcasGA2_TC009122 [Tribolium castaneum] 820858498 XM_003696673.2 207 1.56115e-101 PREDICTED: Apis florea pre-mRNA-splicing factor 38A (LOC100871075), mRNA -- -- -- -- Q5ZIH2 1009 1.1e-107 Vacuolar fusion protein MON1 homolog A OS=Gallus gallus GN=MON1A PE=2 SV=1 PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG0997 Uncharacterized conserved protein Sand Cluster-8309.28508 BP_3 38.72 0.51 3934 642937864 XP_008200330.1 2824 0.0e+00 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEP1 1762 5.1e-195 Protein FAM91A1 OS=Danio rerio GN=fam91a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.2851 BP_3 5.00 2.07 407 795056175 XP_011871767.1 189 3.2e-12 PREDICTED: uncharacterized protein LOC105564172 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28510 BP_3 47.71 0.60 4115 91077536 XP_971011.1 565 8.2e-55 PREDICTED: extensin isoform X1 [Tribolium castaneum]>gi|270002152|gb|EEZ98599.1| hypothetical protein TcasGA2_TC001118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28511 BP_3 75.74 1.62 2548 642931147 XP_008196461.1 1360 3.3e-147 PREDICTED: arginyl-tRNA--protein transferase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K00685 ATE1, ate1 arginine-tRNA-protein transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00685 Q9Z2A5 968 3.9e-103 Arginyl-tRNA--protein transferase 1 OS=Mus musculus GN=Ate1 PE=1 SV=2 PF04376//PF04377 Arginine-tRNA-protein transferase, N terminus//Arginine-tRNA-protein transferase, C terminus GO:0016598 protein arginylation GO:0004057 arginyltransferase activity -- -- KOG1193 Arginyl-tRNA-protein transferase Cluster-8309.28513 BP_3 122.99 3.04 2244 91088073 XP_968074.1 1399 8.7e-152 PREDICTED: arginyl-tRNA--protein transferase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00685 ATE1, ate1 arginine-tRNA-protein transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00685 Q9Z2A5 1028 3.8e-110 Arginyl-tRNA--protein transferase 1 OS=Mus musculus GN=Ate1 PE=1 SV=2 PF04377//PF04376 Arginine-tRNA-protein transferase, C terminus//Arginine-tRNA-protein transferase, N terminus GO:0016598 protein arginylation GO:0004057 arginyltransferase activity -- -- KOG1193 Arginyl-tRNA-protein transferase Cluster-8309.28515 BP_3 67.58 0.70 4917 642935897 XP_008198219.1 1075 7.1e-114 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X2 [Tribolium castaneum] 688627348 LL261331.1 74 1.63384e-27 Echinostoma caproni genome assembly E_caproni_Egypt ,scaffold ECPE_scaffold0027233 K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 Q8NA58 360 2.4e-32 Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 OS=Homo sapiens GN=PNLDC1 PE=2 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.28516 BP_3 1128.87 19.94 3021 642932072 XP_008196845.1 1734 1.7e-190 PREDICTED: thioredoxin domain-containing protein 11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4FUW8 385 1.8e-35 Thioredoxin domain-containing protein 11 OS=Bos taurus GN=TXNDC11 PE=2 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- -- -- Cluster-8309.28517 BP_3 183.63 4.06 2473 642914301 XP_008201628.1 200 1.0e-12 PREDICTED: mediator of RNA polymerase II transcription subunit 28 isoform X1 [Tribolium castaneum] 462293333 APGK01053470.1 36 1.08631e-06 Dendroctonus ponderosae Seq01053480, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF06888//PF02723//PF03153//PF03938 Putative Phosphatase//Non-structural protein NS3/Small envelope protein E//Transcription factor IIA, alpha/beta subunit//Outer membrane protein (OmpH-like) GO:0006367//GO:0008152 transcription initiation from RNA polymerase II promoter//metabolic process GO:0016791//GO:0051082 phosphatase activity//unfolded protein binding GO:0005672//GO:0016020 transcription factor TFIIA complex//membrane -- -- Cluster-8309.28519 BP_3 141.00 25.42 559 642914303 XP_001815546.2 567 6.5e-56 PREDICTED: mediator of RNA polymerase II transcription subunit 28 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15141 MED28 mediator of RNA polymerase II transcription subunit 28 http://www.genome.jp/dbget-bin/www_bget?ko:K15141 Q17P98 351 3.0e-32 Mediator of RNA polymerase II transcription subunit 28 OS=Aedes aegypti GN=MED28 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2852 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28520 BP_3 1006.49 72.18 964 546684237 ERL93942.1 434 3.0e-40 hypothetical protein D910_11228 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28523 BP_3 279.00 9.19 1755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28524 BP_3 601.85 10.64 3019 642933781 XP_008197271.1 3154 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 16 isoform X2 [Tribolium castaneum]>gi|270013594|gb|EFA10042.1| hypothetical protein TcasGA2_TC012214 [Tribolium castaneum] -- -- -- -- -- K09536 DNAJC16 DnaJ homolog subfamily C member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K09536 Q5RCM7 839 4.2e-88 DnaJ homolog subfamily C member 16 OS=Pongo abelii GN=DNAJC16 PE=2 SV=1 PF02180//PF08534//PF00085//PF00578 Bcl-2 homology region 4//Redoxin//Thioredoxin//AhpC/TSA family GO:0006457//GO:0055114//GO:0045454//GO:0042981 protein folding//oxidation-reduction process//cell redox homeostasis//regulation of apoptotic process GO:0031072//GO:0016491//GO:0051082//GO:0016209 heat shock protein binding//oxidoreductase activity//unfolded protein binding//antioxidant activity -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.28527 BP_3 2006.00 25.02 4156 642913636 XP_008201097.1 3169 0.0e+00 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum]>gi|270002053|gb|EEZ98500.1| hypothetical protein TcasGA2_TC001001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W596 1752 7.8e-194 Microtubule-associated protein futsch OS=Drosophila melanogaster GN=futsch PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2853 BP_3 3541.00 494.27 637 478259935 ENN79737.1 154 5.7e-08 hypothetical protein YQE_03793, partial [Dendroctonus ponderosae]>gi|546674730|gb|ERL86039.1| hypothetical protein D910_03453 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28532 BP_3 329472.69 14175.53 1412 270007275 EFA03723.1 344 1.2e-29 hypothetical protein TcasGA2_TC013828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 363 3.0e-33 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.28534 BP_3 4.94 0.75 609 189237918 XP_001811805.1 225 3.2e-16 PREDICTED: transcription initiation factor TFIID subunit 6 [Tribolium castaneum]>gi|270006675|gb|EFA03123.1| hypothetical protein TcasGA2_TC013033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28535 BP_3 6.70 1.82 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28539 BP_3 142.07 7.14 1251 332372700 AEE61492.1 947 1.3e-99 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7QBJ0 606 1.8e-61 UPF0483 protein AGAP003155 OS=Anopheles gambiae GN=AGAP003155 PE=3 SV=3 PF02230//PF06821 Phospholipase/Carboxylesterase//Serine hydrolase -- -- GO:0016787 hydrolase activity -- -- KOG2551 Phospholipase/carboxyhydrolase Cluster-8309.28541 BP_3 87.56 0.92 4898 642914971 XP_008190464.1 1011 1.9e-106 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 2.10528e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 392 4.6e-36 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF01585//PF00322//PF05680//PF06703 G-patch domain//Endothelin family//ATP synthase E chain//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465//GO:0019229//GO:0015992//GO:0015986 signal peptide processing//regulation of vasoconstriction//proton transport//ATP synthesis coupled proton transport GO:0008233//GO:0015078//GO:0003676 peptidase activity//hydrogen ion transmembrane transporter activity//nucleic acid binding GO:0016021//GO:0005787//GO:0000276//GO:0005576 integral component of membrane//signal peptidase complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//extracellular region -- -- Cluster-8309.28542 BP_3 25.28 0.64 2203 321458007 EFX69083.1 2648 1.3e-296 hypothetical protein DAPPUDRAFT_329474 [Daphnia pulex] 657566975 XM_008288631.1 186 3.98511e-90 PREDICTED: Stegastes partitus glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (LOC103362312), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q4KMC4 2263 2.3e-253 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Rattus norvegicus GN=Gfpt2 PE=2 SV=3 PF01380//PF13580 SIS domain//SIS domain GO:0005975 carbohydrate metabolic process GO:0030246 carbohydrate binding -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.28543 BP_3 32.72 0.83 2188 321458007 EFX69083.1 2650 7.4e-297 hypothetical protein DAPPUDRAFT_329474 [Daphnia pulex] 657566975 XM_008288631.1 186 3.95753e-90 PREDICTED: Stegastes partitus glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (LOC103362312), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q4KMC4 2266 1.0e-253 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Rattus norvegicus GN=Gfpt2 PE=2 SV=3 PF13580//PF01380 SIS domain//SIS domain GO:0005975 carbohydrate metabolic process GO:0030246 carbohydrate binding -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.28544 BP_3 45.00 1.22 2074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28545 BP_3 1.00 0.39 413 240849643 NP_001155867.1 196 5.0e-13 translocase of outer mitochondrial membrane 7 homolog [Nasonia vitripennis]>gi|645004190|ref|XP_008208148.1| PREDICTED: translocase of outer mitochondrial membrane 7 homolog isoform X1 [Nasonia vitripennis]>gi|645004192|ref|XP_008208152.1| PREDICTED: translocase of outer mitochondrial membrane 7 homolog isoform X1 [Nasonia vitripennis]>gi|645004194|ref|XP_008208156.1| PREDICTED: translocase of outer mitochondrial membrane 7 homolog isoform X1 [Nasonia vitripennis] -- -- -- -- -- K17771 TOM7 mitochondrial import receptor subunit TOM7 http://www.genome.jp/dbget-bin/www_bget?ko:K17771 Q2KI08 158 5.2e-10 Mitochondrial import receptor subunit TOM7 homolog OS=Bos taurus GN=TOMM7 PE=3 SV=1 PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex KOG4449 Translocase of outer mitochondrial membrane complex, subunit TOM7 Cluster-8309.28548 BP_3 389.01 1.77 10879 270008428 EFA04876.1 8979 0.0e+00 hypothetical protein TcasGA2_TC014935 [Tribolium castaneum] -- -- -- -- -- K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 P42356 4952 0.0e+00 Phosphatidylinositol 4-kinase alpha OS=Homo sapiens GN=PI4KA PE=1 SV=3 PF00107//PF13414//PF00515//PF13374//PF00106//PF00454//PF00899//PF08240//PF13181//PF07721 Zinc-binding dehydrogenase//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//short chain dehydrogenase//Phosphatidylinositol 3- and 4-kinase//ThiF family//Alcohol dehydrogenase GroES-like domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0042802//GO:0016773//GO:0016491//GO:0008641//GO:0005515 identical protein binding//phosphotransferase activity, alcohol group as acceptor//oxidoreductase activity//small protein activating enzyme activity//protein binding -- -- KOG0902 Phosphatidylinositol 4-kinase Cluster-8309.2855 BP_3 5.00 0.32 1037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28550 BP_3 338.04 6.50 2800 270003257 EEZ99704.1 685 6.8e-69 hypothetical protein TcasGA2_TC002465 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q60HE9 463 1.5e-44 Lysosomal alpha-mannosidase OS=Macaca fascicularis GN=MAN2B1 PE=2 SV=1 PF07748 Glycosyl hydrolases family 38 C-terminal domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0015923 mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.28552 BP_3 13.73 0.63 1336 189240443 XP_972854.2 423 7.7e-39 PREDICTED: lysosomal-associated transmembrane protein 4B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00599 Influenza Matrix protein (M2) GO:0015992 proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036 host cell membrane//virion membrane -- -- Cluster-8309.28553 BP_3 435.84 6.65 3449 91078712 XP_966534.1 1635 5.8e-179 PREDICTED: ethanolamine-phosphate cytidylyltransferase [Tribolium castaneum]>gi|270003752|gb|EFA00200.1| hypothetical protein TcasGA2_TC003025 [Tribolium castaneum] -- -- -- -- -- K00967 PCYT2 ethanolamine-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00967 Q5EA75 1228 3.7e-133 Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus GN=PCYT2 PE=2 SV=1 PF01467//PF06574//PF00154//PF02569 Cytidylyltransferase-like//FAD synthetase//recA bacterial DNA recombination protein//Pantoate-beta-alanine ligase GO:0019482//GO:0009058//GO:0006771//GO:0009432//GO:0009231//GO:0006281//GO:0015940 beta-alanine metabolic process//biosynthetic process//riboflavin metabolic process//SOS response//riboflavin biosynthetic process//DNA repair//pantothenate biosynthetic process GO:0016779//GO:0003919//GO:0004592//GO:0005524//GO:0003824//GO:0003697 nucleotidyltransferase activity//FMN adenylyltransferase activity//pantoate-beta-alanine ligase activity//ATP binding//catalytic activity//single-stranded DNA binding -- -- KOG2803 Choline phosphate cytidylyltransferase/Predicted CDP-ethanolamine synthase Cluster-8309.28554 BP_3 823.21 8.47 4979 270005907 EFA02355.1 4597 0.0e+00 hypothetical protein TcasGA2_TC008027 [Tribolium castaneum] 665808556 XM_008554384.1 193 1.16669e-93 PREDICTED: Microplitis demolitor 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase-like (LOC103574835), mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 P13217 3579 0.0e+00 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Drosophila melanogaster GN=norpA PE=1 SV=4 PF00387//PF00168 Phosphatidylinositol-specific phospholipase C, Y domain//C2 domain GO:0006629//GO:0035556//GO:0009395//GO:0046339//GO:0007165 lipid metabolic process//intracellular signal transduction//phospholipid catabolic process//diacylglycerol metabolic process//signal transduction GO:0005515//GO:0004435 protein binding//phosphatidylinositol phospholipase C activity -- -- KOG1265 Phospholipase C Cluster-8309.28555 BP_3 24.45 0.38 3363 189236409 XP_001812701.1 2221 6.3e-247 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase isoform X1 [Tribolium castaneum] 665808556 XM_008554384.1 189 1.31403e-91 PREDICTED: Microplitis demolitor 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase-like (LOC103574835), mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 P13217 1745 4.1e-193 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Drosophila melanogaster GN=norpA PE=1 SV=4 PF00168//PF00387 C2 domain//Phosphatidylinositol-specific phospholipase C, Y domain GO:0006629//GO:0035556//GO:0009395//GO:0007165//GO:0046339 lipid metabolic process//intracellular signal transduction//phospholipid catabolic process//signal transduction//diacylglycerol metabolic process GO:0005515//GO:0004435 protein binding//phosphatidylinositol phospholipase C activity -- -- KOG1265 Phospholipase C Cluster-8309.28556 BP_3 71.76 0.78 4738 189236409 XP_001812701.1 4597 0.0e+00 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase isoform X1 [Tribolium castaneum] 665808556 XM_008554384.1 193 1.10981e-93 PREDICTED: Microplitis demolitor 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase-like (LOC103574835), mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 P13217 3579 0.0e+00 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Drosophila melanogaster GN=norpA PE=1 SV=4 PF00387//PF00168 Phosphatidylinositol-specific phospholipase C, Y domain//C2 domain GO:0007165//GO:0046339//GO:0009395//GO:0035556//GO:0006629 signal transduction//diacylglycerol metabolic process//phospholipid catabolic process//intracellular signal transduction//lipid metabolic process GO:0004435//GO:0005515 phosphatidylinositol phospholipase C activity//protein binding -- -- KOG1265 Phospholipase C Cluster-8309.28558 BP_3 18.42 0.40 2536 91076404 XP_969308.1 1608 5.7e-176 PREDICTED: protein RMD5 homolog A [Tribolium castaneum]>gi|270002561|gb|EEZ99008.1| hypothetical protein TcasGA2_TC004876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H871 995 2.8e-106 Protein RMD5 homolog A OS=Homo sapiens GN=RMND5A PE=1 SV=1 PF16740//PF07926//PF07352//PF04977//PF09177//PF10473 Spindle and kinetochore-associated protein 2//TPR/MLP1/MLP2-like protein//Bacteriophage Mu Gam like protein//Septum formation initiator//Syntaxin 6, N-terminal//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0000090//GO:0006606//GO:0007067//GO:0051301//GO:0031110//GO:0007049//GO:0007059//GO:0042262//GO:0048193 mitotic anaphase//protein import into nucleus//mitotic nuclear division//cell division//regulation of microtubule polymerization or depolymerization//cell cycle//chromosome segregation//DNA protection//Golgi vesicle transport GO:0008134//GO:0045502//GO:0042803//GO:0008017//GO:0003690 transcription factor binding//dynein binding//protein homodimerization activity//microtubule binding//double-stranded DNA binding GO:0005876//GO:0045298//GO:0000940//GO:0016020//GO:0030286//GO:0005667 spindle microtubule//tubulin complex//condensed chromosome outer kinetochore//membrane//dynein complex//transcription factor complex KOG2817 Predicted E3 ubiquitin ligase Cluster-8309.2856 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28561 BP_3 97.28 1.92 2733 270011386 EFA07834.1 320 1.4e-26 hypothetical protein TcasGA2_TC005403 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- -- -- Cluster-8309.28562 BP_3 1826.16 39.68 2510 546681672 ERL91720.1 1516 2.6e-165 hypothetical protein D910_09047 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855//PF01465//PF05478//PF02041 Leucine rich repeat//GRIP domain//Prominin//Auxin binding protein GO:0007165//GO:0000042 signal transduction//protein targeting to Golgi GO:0004872//GO:0005515 receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.28564 BP_3 548.98 86.38 598 91078074 XP_971898.1 262 1.6e-20 PREDICTED: V-type proton ATPase subunit e 2 [Tribolium castaneum] -- -- -- -- -- K02153 ATPeV0E, ATP6H V-type H+-transporting ATPase subunit e http://www.genome.jp/dbget-bin/www_bget?ko:K02153 Q20591 156 1.3e-09 V-type proton ATPase subunit e OS=Caenorhabditis elegans GN=vha-17 PE=3 SV=2 PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG3500 Vacuolar H+-ATPase V0 sector, subunit M9.7 (M9.2) Cluster-8309.28565 BP_3 33.69 1.72 1238 642931814 XP_008196744.1 782 1.7e-80 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 565 1.0e-56 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF06584 Cytochrome P450//DIRP GO:0007049//GO:0055114//GO:0006351 cell cycle//oxidation-reduction process//transcription, DNA-templated GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0017053 transcriptional repressor complex -- -- Cluster-8309.28571 BP_3 640.80 7.70 4303 642923337 XP_008193707.1 2548 9.7e-285 PREDICTED: uncharacterized protein LOC103313102 [Tribolium castaneum]>gi|270007619|gb|EFA04067.1| hypothetical protein TcasGA2_TC014301 [Tribolium castaneum] 170035242 XM_001845428.1 49 1.12784e-13 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- P22792 295 7.1e-25 Carboxypeptidase N subunit 2 OS=Homo sapiens GN=CPN2 PE=1 SV=3 PF00560//PF14999//PF13855 Leucine Rich Repeat//Shadow of prion protein, neuroprotective//Leucine rich repeat -- -- GO:0005515 protein binding GO:0031225 anchored component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.28572 BP_3 424.00 196.71 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28573 BP_3 302.00 7.35 2272 221061293 XP_002262216.1 142 5.0e-06 hypothetical protein, conserved in Plasmodium species [Plasmodium knowlesi strain H]>gi|193811366|emb|CAQ42094.1| hypothetical protein, conserved in Plasmodium species [Plasmodium knowlesi strain H] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28575 BP_3 768.87 10.65 3773 642935735 XP_008198150.1 3183 0.0e+00 PREDICTED: RNA polymerase II-associated protein 1 [Tribolium castaneum]>gi|270013972|gb|EFA10420.1| hypothetical protein TcasGA2_TC012660 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JN53 513 3.3e-50 RNA polymerase II-associated protein 1 OS=Bos taurus GN=RPAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4732 Uncharacterized conserved protein Cluster-8309.28576 BP_3 13.58 0.75 1170 805773862 XP_012137327.1 692 4.4e-70 PREDICTED: papilin isoform X1 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q868Z9 605 2.2e-61 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.28577 BP_3 29.48 1.16 1514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28578 BP_3 788.13 21.00 2101 478251367 ENN71833.1 848 6.4e-88 hypothetical protein YQE_11453, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0P4W3 355 3.8e-32 Regulator of microtubule dynamics protein 2 OS=Xenopus tropicalis GN=rmdn2 PE=2 SV=1 PF13414//PF16740 TPR repeat//Spindle and kinetochore-associated protein 2 GO:0031110//GO:0051301//GO:0007067//GO:0000090//GO:0007059 regulation of microtubule polymerization or depolymerization//cell division//mitotic nuclear division//mitotic anaphase//chromosome segregation GO:0008017//GO:0005515 microtubule binding//protein binding GO:0000940//GO:0005876//GO:0045298 condensed chromosome outer kinetochore//spindle microtubule//tubulin complex -- -- Cluster-8309.28579 BP_3 765.90 10.02 3975 91093345 XP_967700.1 926 1.1e-96 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X9 [Tribolium castaneum] 642938317 XM_962607.3 325 3.89006e-167 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 P81269 205 1.8e-14 Cyclic AMP-dependent transcription factor ATF-1 OS=Mus musculus GN=Atf1 PE=1 SV=1 PF00170//PF07716//PF02173//PF03131 bZIP transcription factor//Basic region leucine zipper//pKID domain//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0005515//GO:0003700 DNA binding//sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.28580 BP_3 19.28 0.37 2809 91091700 XP_972740.1 2698 2.6e-302 PREDICTED: mannosyl-oligosaccharide glucosidase [Tribolium castaneum]>gi|270001063|gb|EEZ97510.1| hypothetical protein TcasGA2_TC011354 [Tribolium castaneum] -- -- -- -- -- K01228 GCS1 mannosyl-oligosaccharide glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01228 F4HTM3 1493 5.7e-164 Mannosyl-oligosaccharide glucosidase GCS1 OS=Arabidopsis thaliana GN=GCS1 PE=1 SV=1 -- -- GO:0009311 oligosaccharide metabolic process GO:0004573 mannosyl-oligosaccharide glucosidase activity -- -- KOG2161 Glucosidase I Cluster-8309.28581 BP_3 25.10 0.92 1606 642910653 XP_968714.2 260 7.4e-20 PREDICTED: polyadenylate-binding protein-interacting protein 2B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28586 BP_3 23.89 1.08 1355 546677930 ERL88668.1 547 3.3e-53 hypothetical protein D910_06052, partial [Dendroctonus ponderosae] -- -- -- -- -- K08495 GOSR1, GOS1 golgi SNAP receptor complex member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08495 Q9VE50 294 2.9e-25 Golgi SNAP receptor complex member 1 OS=Drosophila melanogaster GN=Gos28 PE=2 SV=1 PF08912//PF10384//PF04632 Rho Binding//Centromere protein Scm3//Fusaric acid resistance protein family GO:0006810 transport GO:0017048//GO:0042393 Rho GTPase binding//histone binding GO:0005886//GO:0005634 plasma membrane//nucleus KOG3208 SNARE protein GS28 Cluster-8309.28587 BP_3 231.11 11.03 1302 91084689 XP_968899.1 885 2.0e-92 PREDICTED: Golgi SNAP receptor complex member 1 [Tribolium castaneum]>gi|270008620|gb|EFA05068.1| hypothetical protein TcasGA2_TC015165 [Tribolium castaneum] -- -- -- -- -- K08495 GOSR1, GOS1 golgi SNAP receptor complex member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08495 Q9VE50 576 5.6e-58 Golgi SNAP receptor complex member 1 OS=Drosophila melanogaster GN=Gos28 PE=2 SV=1 PF08912//PF04632 Rho Binding//Fusaric acid resistance protein family GO:0006888//GO:0006810//GO:0015031 ER to Golgi vesicle-mediated transport//transport//protein transport GO:0017048 Rho GTPase binding GO:0005886//GO:0016021//GO:0005801//GO:0000139 plasma membrane//integral component of membrane//cis-Golgi network//Golgi membrane KOG3208 SNARE protein GS28 Cluster-8309.28588 BP_3 158.05 3.85 2271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28590 BP_3 521.69 21.92 1439 546681363 ERL91473.1 1521 4.0e-166 hypothetical protein D910_08803 [Dendroctonus ponderosae] 817195914 XM_012418095.1 260 1.88527e-131 PREDICTED: Orussus abietinus cAMP-dependent protein kinase type I regulatory subunit (LOC105695993), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P16905 1373 2.4e-150 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.28591 BP_3 247.69 1.81 6887 270012867 EFA09315.1 1048 1.3e-110 hypothetical protein TcasGA2_TC030748 [Tribolium castaneum] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 532 3.8e-52 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 PF04420//PF08288//PF07830 CHD5-like protein//PIGA (GPI anchor biosynthesis)//Protein serine/threonine phosphatase 2C, C-terminal domain GO:0006506//GO:0071816//GO:0006470 GPI anchor biosynthetic process//tail-anchored membrane protein insertion into ER membrane//protein dephosphorylation GO:0000287//GO:0004721//GO:0030145 magnesium ion binding//phosphoprotein phosphatase activity//manganese ion binding -- -- KOG2687 Spindle pole body protein, contains UNC-84 domain Cluster-8309.28593 BP_3 16.80 0.31 2932 642928862 XP_008195593.1 1089 1.0e-115 PREDICTED: probable ATP-dependent RNA helicase DDX43 [Tribolium castaneum] -- -- -- -- -- K17043 DDX43 ATP-dependent RNA helicase DDX43 http://www.genome.jp/dbget-bin/www_bget?ko:K17043 Q9NXZ2 762 3.4e-79 Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens GN=DDX43 PE=2 SV=2 PF07650//PF00270//PF04851//PF13014//PF00176//PF02730//PF00013 KH domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//KH domain//SNF2 family N-terminal domain//Aldehyde ferredoxin oxidoreductase, N-terminal domain//KH domain GO:0055114 oxidation-reduction process GO:0016491//GO:0003723//GO:0005524//GO:0003677//GO:0016787//GO:0016625//GO:0051536//GO:0003676 oxidoreductase activity//RNA binding//ATP binding//DNA binding//hydrolase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//iron-sulfur cluster binding//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.28594 BP_3 8.00 0.33 1462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28596 BP_3 135.26 1.46 4769 642914654 XP_008190301.1 1656 2.9e-181 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.73957e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.3e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF00170//PF07716 bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.28597 BP_3 4.00 0.55 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28598 BP_3 14.99 0.55 1617 478258605 ENN78655.1 928 2.6e-97 hypothetical protein YQE_04828, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.286 BP_3 3.00 0.70 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28600 BP_3 108.86 1.44 3948 642919036 XP_008191706.1 1793 3.2e-197 PREDICTED: uncharacterized protein LOC663686 isoform X2 [Tribolium castaneum] 749755207 XM_011141773.1 86 2.79471e-34 PREDICTED: Harpegnathos saltator uncharacterized LOC105183546 (LOC105183546), mRNA -- -- -- -- -- -- -- -- PF01160 Vertebrate endogenous opioids neuropeptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.28601 BP_3 54.53 1.08 2729 189239830 XP_001813387.1 1186 5.3e-127 PREDICTED: Meckel syndrome type 1 protein [Tribolium castaneum]>gi|270011929|gb|EFA08377.1| hypothetical protein TcasGA2_TC006020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXB0 512 3.1e-50 Meckel syndrome type 1 protein OS=Homo sapiens GN=MKS1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28603 BP_3 13.68 0.48 1663 665820747 XP_008559286.1 1588 7.8e-174 PREDICTED: guanine nucleotide-binding protein subunit beta-5 [Microplitis demolitor] 807025222 XM_004523529.2 188 2.31335e-91 PREDICTED: Ceratitis capitata guanine nucleotide-binding protein subunit beta-5 (LOC101456443), mRNA K04539 GNB5 guanine nucleotide-binding protein subunit beta-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04539 Q6PNB6 1295 3.0e-141 Guanine nucleotide-binding protein subunit beta-5 OS=Oryctolagus cuniculus GN=GNB5 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.28604 BP_3 23.59 0.36 3421 270016432 EFA12878.1 1083 5.8e-115 hypothetical protein TcasGA2_TC011556 [Tribolium castaneum] 642939326 XM_008202184.1 254 9.83584e-128 PREDICTED: Tribolium castaneum DCN1-like protein 4 (LOC657768), mRNA K17824 DCUN1D4_5 DCN1-like protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K17824 Q5RHX6 774 1.6e-80 DCN1-like protein 4 OS=Danio rerio GN=dcun1d4 PE=3 SV=2 PF06268 Fascin domain -- -- GO:0030674//GO:0051015 protein binding, bridging//actin filament binding -- -- KOG3962 Predicted actin-bundling protein Cluster-8309.28605 BP_3 47.00 1.03 2484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28606 BP_3 54.18 2.27 1444 642936242 XP_008198362.1 1627 2.0e-178 PREDICTED: polypyrimidine tract-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 781 1.1e-81 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.28607 BP_3 327.33 3.71 4547 270013160 EFA09608.1 920 6.2e-96 hypothetical protein TcasGA2_TC011728 [Tribolium castaneum] 642936249 XM_008200144.1 221 2.89817e-109 PREDICTED: Tribolium castaneum polypyrimidine tract-binding protein 1 (LOC654951), transcript variant X5, mRNA K14948 PTBP2, NPTB polypyrimidine tract-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14948 Q00438 675 6.5e-69 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF08675//PF01405//PF00076 RNA binding domain//Photosystem II reaction centre T protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0051252//GO:0015979//GO:0006402 regulation of RNA metabolic process//photosynthesis//mRNA catabolic process GO:0046872//GO:0003676//GO:0004535//GO:0003723 metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity//RNA binding GO:0009539//GO:0005737//GO:0009523//GO:0016020//GO:0005634 photosystem II reaction center//cytoplasm//photosystem II//membrane//nucleus KOG1190 Polypyrimidine tract-binding protein Cluster-8309.28609 BP_3 318.18 2.76 5844 642939380 XP_008193163.1 2484 3.5e-277 PREDICTED: hemicentin-1 isoform X3 [Tribolium castaneum] 642939379 XM_008194941.1 107 8.79284e-46 PREDICTED: Tribolium castaneum hemicentin-1 (LOC660515), transcript variant X3, mRNA -- -- -- -- Q8WZ42 332 5.0e-29 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF00558//PF00895//PF05510//PF13895//PF06377//PF00957 Vpu protein//ATP synthase protein 8//Sarcoglycan alpha/epsilon//Immunoglobulin domain//Adipokinetic hormone//Synaptobrevin GO:0015992//GO:0032801//GO:0006812//GO:0015986//GO:0016192//GO:0019076//GO:0007165 proton transport//receptor catabolic process//cation transport//ATP synthesis coupled proton transport//vesicle-mediated transport//viral release from host cell//signal transduction GO:0015078//GO:0005179//GO:0005261//GO:0005515 hydrogen ion transmembrane transporter activity//hormone activity//cation channel activity//protein binding GO:0033644//GO:0016012//GO:0000276//GO:0016021 host cell membrane//sarcoglycan complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.2861 BP_3 4.00 0.60 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28610 BP_3 3457.85 47.92 3770 189242341 XP_001807206.1 2621 2.9e-293 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270016565|gb|EFA13011.1| hypothetical protein TcasGA2_TC001976 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 314 3.9e-27 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28613 BP_3 88.90 2.79 1830 478263026 ENN81426.1 1545 8.4e-169 hypothetical protein YQE_02120, partial [Dendroctonus ponderosae]>gi|546686068|gb|ERL95468.1| hypothetical protein D910_12730 [Dendroctonus ponderosae] 56251666 CR676700.2 57 1.69492e-18 Tetraodon nigroviridis full-length cDNA K10755 RFC2_4 replication factor C subunit 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10755 P53033 1260 3.8e-137 Replication factor C subunit 2 OS=Gallus gallus GN=RFC2 PE=2 SV=1 PF07728//PF05496//PF01443//PF00004//PF06144//PF07726//PF03266//PF00005//PF00270//PF00910 AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//ATPase family associated with various cellular activities (AAA)//DNA polymerase III, delta subunit//ATPase family associated with various cellular activities (AAA)//NTPase//ABC transporter//DEAD/DEAH box helicase//RNA helicase GO:0006310//GO:0006281//GO:0006260 DNA recombination//DNA repair//DNA replication GO:0003723//GO:0003677//GO:0003887//GO:0003676//GO:0009378//GO:0003724//GO:0005524//GO:0098519//GO:0016887 RNA binding//DNA binding//DNA-directed DNA polymerase activity//nucleic acid binding//four-way junction helicase activity//RNA helicase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//ATPase activity GO:0005657//GO:0009360//GO:0009379//GO:0042575 replication fork//DNA polymerase III complex//Holliday junction helicase complex//DNA polymerase complex KOG0991 Replication factor C, subunit RFC2 Cluster-8309.28615 BP_3 65.93 1.01 3439 91078790 XP_969765.1 2074 7.2e-230 PREDICTED: retinoblastoma-binding protein 5 [Tribolium castaneum]>gi|270003731|gb|EFA00179.1| hypothetical protein TcasGA2_TC003004 [Tribolium castaneum] 815929092 XM_003494688.2 345 2.56149e-178 PREDICTED: Bombus impatiens retinoblastoma-binding protein 5 homolog (LOC100746759), mRNA K14961 RBBP5, SWD1, CPS50 COMPASS component SWD1 http://www.genome.jp/dbget-bin/www_bget?ko:K14961 Q9VPH8 1792 1.5e-198 Retinoblastoma-binding protein 5 homolog OS=Drosophila melanogaster GN=Rbbp5 PE=1 SV=2 PF01459//PF01239//PF00400 Eukaryotic porin//Protein prenyltransferase alpha subunit repeat//WD domain, G-beta repeat GO:0018342//GO:0055085 protein prenylation//transmembrane transport GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity GO:0005741 mitochondrial outer membrane KOG1273 WD40 repeat protein Cluster-8309.28620 BP_3 9.00 4.60 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28622 BP_3 1.00 0.51 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28624 BP_3 2.00 0.84 405 478252918 ENN73302.1 158 1.2e-08 hypothetical protein YQE_10066, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03504 Chlamydia cysteine-rich outer membrane protein 6 -- -- GO:0005201 extracellular matrix structural constituent GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.28628 BP_3 32.79 0.93 1991 642917175 XP_008191150.1 285 1.2e-22 PREDICTED: pangolin isoform X2 [Tribolium castaneum] 55832417 AY800246.1 158 1.32088e-74 Tribolium castaneum pangolin gene, partial cds K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 Q9NQB0 206 6.9e-15 Transcription factor 7-like 2 OS=Homo sapiens GN=TCF7L2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3248 Transcription factor TCF-4 Cluster-8309.28629 BP_3 6.17 0.33 1207 546683825 ERL93578.1 502 4.8e-48 hypothetical protein D910_10866 [Dendroctonus ponderosae] -- -- -- -- -- K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q06190 158 1.5e-09 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha OS=Homo sapiens GN=PPP2R3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28631 BP_3 103.01 1.84 2988 573875180 XP_006625928.1 321 1.2e-26 PREDICTED: serine/threonine-protein kinase Nek2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- O35942 287 4.2e-24 Serine/threonine-protein kinase Nek2 OS=Mus musculus GN=Nek2 PE=1 SV=2 PF08040//PF00800//PF07714//PF00069 MNLL subunit//Prephenate dehydratase//Protein tyrosine kinase//Protein kinase domain GO:0006118//GO:0009094//GO:0000162//GO:0006571//GO:0006468 obsolete electron transport//L-phenylalanine biosynthetic process//tryptophan biosynthetic process//tyrosine biosynthetic process//protein phosphorylation GO:0004672//GO:0005524//GO:0004664//GO:0003954 protein kinase activity//ATP binding//prephenate dehydratase activity//NADH dehydrogenase activity GO:0005739 mitochondrion -- -- Cluster-8309.28634 BP_3 76.81 0.80 4892 642921170 XP_008192744.1 2383 1.5e-265 PREDICTED: ATP-binding cassette sub-family B member 10, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K05657 ABCB10 ATP-binding cassette, subfamily B (MDR/TAP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05657 Q9NRK6 1543 1.6e-169 ATP-binding cassette sub-family B member 10, mitochondrial OS=Homo sapiens GN=ABCB10 PE=1 SV=2 PF14991//PF00005//PF03193//PF07728//PF00664//PF06414//PF13304 Protein melan-A//ABC transporter//Protein of unknown function, DUF258//AAA domain (dynein-related subfamily)//ABC transporter transmembrane region//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626 ATP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0042470 integral component of membrane//melanosome KOG0058 Peptide exporter, ABC superfamily Cluster-8309.28636 BP_3 560.44 16.79 1901 270013779 EFA10227.1 582 4.0e-57 hypothetical protein TcasGA2_TC012423 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20241 232 6.4e-18 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- KOG3513 Neural cell adhesion molecule L1 Cluster-8309.2864 BP_3 612.00 50.92 871 270007265 EFA03713.1 353 6.6e-31 hypothetical protein TcasGA2_TC013818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 243 1.5e-19 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.28643 BP_3 1448.90 18.40 4087 189241411 XP_970340.2 5384 0.0e+00 PREDICTED: attractin-like protein 1 [Tribolium castaneum]>gi|270014130|gb|EFA10578.1| hypothetical protein TcasGA2_TC012834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6A051 1305 5.2e-142 Attractin-like protein 1 OS=Mus musculus GN=Atrnl1 PE=1 SV=2 PF01344//PF01437//PF07646 Kelch motif//Plexin repeat//Kelch motif -- -- GO:0005515 protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG1388 Attractin and platelet-activating factor acetylhydrolase Cluster-8309.28644 BP_3 35.10 0.32 5654 189241411 XP_970340.2 4840 0.0e+00 PREDICTED: attractin-like protein 1 [Tribolium castaneum]>gi|270014130|gb|EFA10578.1| hypothetical protein TcasGA2_TC012834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6A051 1305 7.2e-142 Attractin-like protein 1 OS=Mus musculus GN=Atrnl1 PE=1 SV=2 PF07646//PF01344//PF01437 Kelch motif//Kelch motif//Plexin repeat -- -- GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1388 Attractin and platelet-activating factor acetylhydrolase Cluster-8309.28645 BP_3 146.91 0.90 8151 642920053 XP_008192184.1 1927 1.9e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 2.75388e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 2.7e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF08159//PF03822//PF08445//PF13508//PF00583//PF02297//PF03396//PF13673//PF00159 NUC153 domain//NAF domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Cytochrome oxidase c subunit VIb//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide GO:0019083//GO:0007165//GO:0006123//GO:0042967//GO:0015992//GO:0006351//GO:0006144//GO:0006206 viral transcription//signal transduction//mitochondrial electron transport, cytochrome c to oxygen//acyl-carrier-protein biosynthetic process//proton transport//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005179//GO:0008080//GO:0016747//GO:0004129 DNA-directed RNA polymerase activity//DNA binding//hormone activity//N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity GO:0005739//GO:0005730//GO:0005634//GO:0045277//GO:0005576 mitochondrion//nucleolus//nucleus//respiratory chain complex IV//extracellular region KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.28646 BP_3 292.14 1.25 11531 642920053 XP_008192184.1 2013 2.8e-222 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.90105e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.9e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF03822//PF08159//PF08445//PF13508//PF00583//PF08112//PF02297//PF00159//PF13673 NAF domain//NUC153 domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//ATP synthase epsilon subunit//Cytochrome oxidase c subunit VIb//Pancreatic hormone peptide//Acetyltransferase (GNAT) domain GO:0015986//GO:0015992//GO:0006810//GO:0042967//GO:0006123//GO:0007165 ATP synthesis coupled proton transport//proton transport//transport//acyl-carrier-protein biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//signal transduction GO:0004129//GO:0016747//GO:0008080//GO:0005179//GO:0042626 cytochrome-c oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//hormone activity//ATPase activity, coupled to transmembrane movement of substances GO:0005576//GO:0045277//GO:0005634//GO:0005739//GO:0033178 extracellular region//respiratory chain complex IV//nucleus//mitochondrion//proton-transporting two-sector ATPase complex, catalytic domain KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.28647 BP_3 138.64 1.58 4519 478261514 ENN80859.1 815 9.2e-84 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K08648 HABP2 hyaluronan binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08648 P13582 508 1.5e-49 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.28648 BP_3 8.16 0.34 1447 642927692 XP_008196560.1 729 2.8e-74 PREDICTED: DNA-directed RNA polymerase I subunit RPA49-like [Tribolium castaneum]>gi|270009901|gb|EFA06349.1| hypothetical protein TcasGA2_TC009224 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06870 A49-like RNA polymerase I associated factor GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.28649 BP_3 129.84 5.68 1393 642927692 XP_008196560.1 758 1.2e-77 PREDICTED: DNA-directed RNA polymerase I subunit RPA49-like [Tribolium castaneum]>gi|270009901|gb|EFA06349.1| hypothetical protein TcasGA2_TC009224 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06870 A49-like RNA polymerase I associated factor GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.2865 BP_3 7.00 1.14 588 642915846 XP_970956.2 355 2.6e-31 PREDICTED: uncharacterized protein LOC659571 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.28650 BP_3 158.35 1.55 5229 642920483 XP_008192370.1 2537 2.2e-283 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86W92 885 3.3e-93 Liprin-beta-1 OS=Homo sapiens GN=PPFIBP1 PE=1 SV=2 PF07647//PF01496//PF02601//PF00536//PF01763//PF02198 SAM domain (Sterile alpha motif)//V-type ATPase 116kDa subunit family//Exonuclease VII, large subunit//SAM domain (Sterile alpha motif)//Herpesvirus UL6 like//Sterile alpha motif (SAM)/Pointed domain GO:0015992//GO:0006308//GO:0006323//GO:0015991 proton transport//DNA catabolic process//DNA packaging//ATP hydrolysis coupled proton transport GO:0015078//GO:0043565//GO:0005515//GO:0008855 hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//protein binding//exodeoxyribonuclease VII activity GO:0009318//GO:0033179//GO:0005634 exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain//nucleus KOG0249 LAR-interacting protein and related proteins Cluster-8309.28651 BP_3 116.98 0.65 8907 642910256 XP_008198577.1 1690 6.3e-185 PREDICTED: protein capicua homolog isoform X3 [Tribolium castaneum] 642910255 XM_008200355.1 145 1.0088e-66 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X3, mRNA -- -- -- -- Q96RK0 381 1.6e-34 Protein capicua homolog OS=Homo sapiens GN=CIC PE=1 SV=2 PF08288 PIGA (GPI anchor biosynthesis) GO:0006506 GPI anchor biosynthetic process -- -- -- -- KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.28652 BP_3 51.66 0.35 7313 641654113 XP_008179076.1 1316 1.2e-141 PREDICTED: putative transcription factor capicua isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q924A2 381 1.3e-34 Protein capicua homolog OS=Mus musculus GN=Cic PE=1 SV=2 PF08288//PF00737 PIGA (GPI anchor biosynthesis)//Photosystem II 10 kDa phosphoprotein GO:0006506//GO:0050821//GO:0015979 GPI anchor biosynthetic process//protein stabilization//photosynthesis GO:0042301 phosphate ion binding GO:0016020//GO:0009523 membrane//photosystem II KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.28653 BP_3 1076.46 6.17 8705 189233577 XP_968497.2 1756 1.4e-192 PREDICTED: protein capicua homolog isoform X1 [Tribolium castaneum]>gi|270015125|gb|EFA11573.1| capicua [Tribolium castaneum] 642910253 XM_008200351.1 160 4.52217e-75 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X2, mRNA -- -- -- -- Q96RK0 381 1.5e-34 Protein capicua homolog OS=Homo sapiens GN=CIC PE=1 SV=2 PF08288 PIGA (GPI anchor biosynthesis) GO:0006506 GPI anchor biosynthetic process -- -- -- -- KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.28654 BP_3 5025.35 135.52 2079 478250009 ENN70515.1 538 5.6e-52 hypothetical protein YQE_12691, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VTI8 332 1.8e-29 Protein charybde OS=Drosophila melanogaster GN=chrb PE=2 SV=2 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.28655 BP_3 25.53 1.77 988 -- -- -- -- -- 820855726 XM_012489619.1 67 2.48772e-24 PREDICTED: Apis florea hepatic leukemia factor (LOC100863581), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28659 BP_3 2676.03 72.05 2082 270014846 EFA11294.1 1705 2.7e-187 hypothetical protein TcasGA2_TC010831 [Tribolium castaneum] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 P41239 1033 9.2e-111 Tyrosine-protein kinase CSK OS=Gallus gallus GN=CSK PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.2866 BP_3 3.00 0.68 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28661 BP_3 182.14 3.14 3088 91075916 XP_966441.1 3317 0.0e+00 PREDICTED: exocyst complex component 2 [Tribolium castaneum]>gi|270014638|gb|EFA11086.1| hypothetical protein TcasGA2_TC004683 [Tribolium castaneum] -- -- -- -- -- K17637 EXOC2, SEC5 exocyst complex component 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17637 Q9VQQ9 1888 9.8e-210 Exocyst complex component 2 OS=Drosophila melanogaster GN=sec5 PE=2 SV=1 PF04437//PF01833 RINT-1 / TIP-1 family//IPT/TIG domain GO:0048193 Golgi vesicle transport GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG2347 Sec5 subunit of exocyst complex Cluster-8309.28662 BP_3 208.85 3.05 3587 642936999 XP_968421.2 962 6.6e-101 PREDICTED: 60 kDa SS-A/Ro ribonucleoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42700 346 7.3e-31 60 kDa SS-A/Ro ribonucleoprotein OS=Xenopus laevis GN=trove2 PE=1 SV=1 PF02285//PF05731 Cytochrome oxidase c subunit VIII//TROVE domain GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003723 cytochrome-c oxidase activity//RNA binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.28666 BP_3 404.06 4.53 4588 270005308 EFA01756.1 572 1.4e-55 hypothetical protein TcasGA2_TC007354 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- -- -- Cluster-8309.28670 BP_3 619.16 10.71 3078 91088947 XP_973771.1 2772 7.2e-311 PREDICTED: exocyst complex component 3 [Tribolium castaneum]>gi|270012371|gb|EFA08819.1| hypothetical protein TcasGA2_TC006514 [Tribolium castaneum] -- -- -- -- -- K06110 EXOC3, SEC6L1 exocyst complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06110 Q9V8K2 1730 2.0e-191 Exocyst complex component 3 OS=Drosophila melanogaster GN=sec6 PE=2 SV=2 PF05192//PF03283//PF06046 MutS domain III//Pectinacetylesterase//Exocyst complex component Sec6 GO:0006887//GO:0006298 exocytosis//mismatch repair GO:0016787//GO:0030983//GO:0005524 hydrolase activity//mismatched DNA binding//ATP binding GO:0000145 exocyst KOG2286 Exocyst complex subunit SEC6 Cluster-8309.28671 BP_3 100.28 1.40 3743 546683632 ERL93420.1 1145 4.1e-122 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 P57095 334 1.9e-29 Axin-2 OS=Danio rerio GN=axin2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28672 BP_3 50.45 3.07 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28673 BP_3 7.00 1.15 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28674 BP_3 6.25 0.34 1170 478260763 ENN80436.1 660 2.2e-66 hypothetical protein YQE_03140, partial [Dendroctonus ponderosae]>gi|546683758|gb|ERL93523.1| hypothetical protein D910_10812 [Dendroctonus ponderosae] 685042175 LN590700.1 37 1.40611e-07 Cyprinus carpio genome assembly common carp genome ,scaffold LG10 K12165 UFC1 ufm1-conjugating enzyme 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12165 C1BZU2 631 2.1e-64 Ubiquitin-fold modifier-conjugating enzyme 1 OS=Esox lucius GN=ufc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3357 Uncharacterized conserved protein Cluster-8309.28675 BP_3 673.91 8.12 4294 189241218 XP_971240.2 3957 0.0e+00 PREDICTED: trafficking protein particle complex subunit 11 isoform X1 [Tribolium castaneum] 805824905 XM_003708183.2 71 6.63129e-26 PREDICTED: Megachile rotundata trafficking protein particle complex subunit 11 (LOC100881733), mRNA -- -- -- -- Q7Z392 2179 2.5e-243 Trafficking protein particle complex subunit 11 OS=Homo sapiens GN=TRAPPC11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4386 Uncharacterized conserved protein Cluster-8309.28676 BP_3 156.33 9.64 1073 91090510 XP_969573.1 1015 1.4e-107 PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum]>gi|642935364|ref|XP_008197982.1| PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q8IYP9 147 2.6e-08 Palmitoyltransferase ZDHHC23 OS=Homo sapiens GN=ZDHHC23 PE=1 SV=3 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.28677 BP_3 7.27 0.55 928 61394183 AAX45784.1 605 4.2e-60 glucose-6-phosphate dehydrogenase isoform A [Ips typographus] 689948381 LM437039.1 35 1.43315e-06 Nippostrongylus brasiliensis genome assembly N_brasiliensis_RM07_v1_5_4 ,scaffold NBR_contig0000216 K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P41571 543 2.7e-54 Glucose-6-phosphate 1-dehydrogenase OS=Ceratitis capitata GN=ZW PE=2 SV=1 PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain GO:0055114//GO:0006098//GO:0006749//GO:0006006 oxidation-reduction process//pentose-phosphate shunt//glutathione metabolic process//glucose metabolic process GO:0004345//GO:0050661 glucose-6-phosphate dehydrogenase activity//NADP binding -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.28678 BP_3 19.02 0.36 2805 91078996 XP_974675.1 283 2.8e-22 PREDICTED: zinc transporter ZIP1 [Tribolium castaneum]>gi|270003679|gb|EFA00127.1| hypothetical protein TcasGA2_TC002943 [Tribolium castaneum] -- -- -- -- -- K14709 SLC39A1_2_3, ZIP1_2_3 solute carrier family 39 (zinc transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14709 -- -- -- -- PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.28679 BP_3 23.39 0.36 3398 91091374 XP_973014.1 2065 7.8e-229 PREDICTED: FACT complex subunit Ssrp1 [Tribolium castaneum] 759066034 XM_011344158.1 265 7.49867e-134 PREDICTED: Cerapachys biroi FACT complex subunit Ssrp1 (LOC105282288), mRNA K09272 SSRP1 structure-specific recognition protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09272 Q293F6 1703 3.0e-188 FACT complex subunit Ssrp1 OS=Drosophila pseudoobscura pseudoobscura GN=Ssrp PE=3 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG0526 Nucleosome-binding factor SPN, POB3 subunit Cluster-8309.2868 BP_3 33.00 0.96 1955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- -- -- Cluster-8309.28680 BP_3 671.08 9.44 3719 546684921 ERL94503.1 2397 2.7e-267 hypothetical protein D910_11780 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96MT7 747 2.4e-77 Cilia- and flagella-associated protein 44 OS=Homo sapiens GN=CFAP44 PE=1 SV=1 PF00400//PF00591 WD domain, G-beta repeat//Glycosyl transferase family, a/b domain GO:0008152 metabolic process GO:0005515//GO:0016757 protein binding//transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.28681 BP_3 301.40 4.94 3233 642924596 XP_008194357.1 2788 0.0e+00 PREDICTED: putative ATP-dependent RNA helicase DHX33 [Tribolium castaneum]>gi|270006741|gb|EFA03189.1| hypothetical protein TcasGA2_TC013109 [Tribolium castaneum] -- -- -- -- -- K17820 DHX33 ATP-dependent RNA helicase DHX33 http://www.genome.jp/dbget-bin/www_bget?ko:K17820 Q80VY9 1714 1.5e-189 Putative ATP-dependent RNA helicase DHX33 OS=Mus musculus GN=Dhx33 PE=1 SV=1 PF04408//PF01637//PF04851//PF00005//PF07652//PF00270//PF00437 Helicase associated domain (HA2)//Archaeal ATPase//Type III restriction enzyme, res subunit//ABC transporter//Flavivirus DEAD domain//DEAD/DEAH box helicase//Type II/IV secretion system protein GO:0006810//GO:0019079 transport//viral genome replication GO:0008026//GO:0005524//GO:0004386//GO:0016787//GO:0003677//GO:0003676//GO:0016887 ATP-dependent helicase activity//ATP binding//helicase activity//hydrolase activity//DNA binding//nucleic acid binding//ATPase activity -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.28682 BP_3 591.89 14.88 2209 332373870 AEE62076.1 1566 3.7e-171 unknown [Dendroctonus ponderosae] 198456406 XM_001360273.2 35 3.484e-06 Drosophila pseudoobscura pseudoobscura GA13487 (Dpse\GA13487), partial mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 909 2.3e-96 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.28685 BP_3 265.48 5.27 2722 91083281 XP_974400.1 2330 1.2e-259 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|270007725|gb|EFA04173.1| hypothetical protein TcasGA2_TC014422 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.28686 BP_3 27.21 0.52 2817 270004278 EFA00726.1 299 3.9e-24 hypothetical protein TcasGA2_TC003607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28687 BP_3 125.90 1.65 3973 642916650 XP_008192038.1 229 7.2e-16 PREDICTED: uncharacterized protein LOC103312652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28691 BP_3 14.91 0.50 1732 642917767 XP_008191359.1 1648 9.0e-181 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 588 3.0e-59 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF01266//PF07992//PF05834//PF00732 GMC oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase GO:0055114//GO:0016117//GO:0044710 oxidation-reduction process//carotenoid biosynthetic process//single-organism metabolic process GO:0016491//GO:0016705//GO:0016614//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.28692 BP_3 973.23 15.05 3408 270297180 NP_001161912.1 858 7.2e-89 cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|268309002|gb|ACY95467.1| cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|270001714|gb|EEZ98161.1| hypothetical protein TcasGA2_TC000587 [Tribolium castaneum] 817213894 XM_012427772.1 132 6.46497e-60 PREDICTED: Orussus abietinus uncharacterized LOC105701218 (LOC105701218), mRNA -- -- -- -- -- -- -- -- PF01607//PF02975 Chitin binding Peritrophin-A domain//Methylamine dehydrogenase, L chain GO:0006030//GO:0009308//GO:0055114 chitin metabolic process//amine metabolic process//oxidation-reduction process GO:0008061//GO:0016638 chitin binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0005576//GO:0042597 extracellular region//periplasmic space -- -- Cluster-8309.28693 BP_3 1153.04 17.66 3439 189237964 XP_001813896.1 3338 0.0e+00 PREDICTED: Golgi apparatus protein 1 [Tribolium castaneum]>gi|270006658|gb|EFA03106.1| hypothetical protein TcasGA2_TC013016 [Tribolium castaneum] -- -- -- -- -- K06816 GLG1, ESL1 golgi apparatus protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06816 Q02391 2052 1.0e-228 Golgi apparatus protein 1 OS=Gallus gallus GN=GLG1 PE=1 SV=1 PF00839 Cysteine rich repeat -- -- -- -- GO:0016020 membrane KOG3648 Golgi apparatus protein (cysteine-rich fibroblast growth factor receptor) Cluster-8309.28694 BP_3 52.43 0.71 3865 189237964 XP_001813896.1 2199 2.6e-244 PREDICTED: Golgi apparatus protein 1 [Tribolium castaneum]>gi|270006658|gb|EFA03106.1| hypothetical protein TcasGA2_TC013016 [Tribolium castaneum] -- -- -- -- -- K06816 GLG1, ESL1 golgi apparatus protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06816 Q02391 1443 4.9e-158 Golgi apparatus protein 1 OS=Gallus gallus GN=GLG1 PE=1 SV=1 PF11791//PF10723//PF00839 Aconitate B N-terminal domain//Replication regulatory protein RepB//Cysteine rich repeat GO:0046487//GO:0019643//GO:0006276//GO:0006099 glyoxylate metabolic process//reductive tricarboxylic acid cycle//plasmid maintenance//tricarboxylic acid cycle GO:0003994 aconitate hydratase activity GO:0016020 membrane KOG3648 Golgi apparatus protein (cysteine-rich fibroblast growth factor receptor) Cluster-8309.28696 BP_3 60.63 5.65 809 641647727 XP_008179395.1 242 4.6e-18 PREDICTED: jerky protein homolog-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF05720 helix-turn-helix, Psq domain//Cell-cell adhesion domain GO:0007155 cell adhesion GO:0003677 DNA binding -- -- -- -- Cluster-8309.28697 BP_3 1623.00 57.01 1664 270009554 EFA06002.1 986 5.0e-104 hypothetical protein TcasGA2_TC008828 [Tribolium castaneum] -- -- -- -- -- K08742 SIAH2 E3 ubiquitin-protein ligase SIAH2 http://www.genome.jp/dbget-bin/www_bget?ko:K08742 A8X679 278 2.6e-23 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis briggsae GN=siah-1 PE=3 SV=2 PF15965//PF00097//PF03145//PF02891 TRAF-like zinc-finger//Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//MIZ/SP-RING zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.28698 BP_3 621.50 7.12 4500 642930899 XP_008196132.1 1295 2.0e-139 PREDICTED: protein suppressor of sable isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22293 356 6.3e-32 Protein suppressor of sable OS=Drosophila melanogaster GN=su(s) PE=1 SV=2 PF00642//PF06440 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//DNA polymerase III, theta subunit GO:0006260 DNA replication GO:0003887//GO:0046872//GO:0003677 DNA-directed DNA polymerase activity//metal ion binding//DNA binding GO:0042575 DNA polymerase complex KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.287 BP_3 131.00 4.45 1712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2870 BP_3 4.00 0.71 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28700 BP_3 15.20 0.43 1981 642915929 XP_008190815.1 150 5.2e-07 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05531//PF16331 Nucleopolyhedrovirus P10 protein//TolA binding protein trimerisation GO:0070206 protein trimerization -- -- GO:0019028 viral capsid -- -- Cluster-8309.28701 BP_3 179.00 16.81 805 270009937 EFA06385.1 346 4.0e-30 hypothetical protein TcasGA2_TC009263 [Tribolium castaneum] -- -- -- -- -- K08493 VTI1 vesicle transport through interaction with t-SNAREs 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08493 Q9UEU0 192 1.2e-13 Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens GN=VTI1B PE=1 SV=3 PF00523 Fusion glycoprotein F0 GO:0006948 induction by virus of host cell-cell fusion -- -- -- -- KOG1666 V-SNARE Cluster-8309.28706 BP_3 457.25 3.53 6542 642924126 XP_008194016.1 8939 0.0e+00 PREDICTED: neural-cadherin isoform X1 [Tribolium castaneum] 642924129 XM_008195796.1 2108 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X3, mRNA -- -- -- -- O15943 8312 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF01049//PF00028//PF00008 Cadherin cytoplasmic region//Cadherin domain//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.28707 BP_3 1249.22 9.63 6542 642924132 XP_008194019.1 8991 0.0e+00 PREDICTED: neural-cadherin isoform X4 [Tribolium castaneum] 642924131 XM_008195797.1 2150 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X4, mRNA -- -- -- -- O15943 8442 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF00008//PF01049//PF00028 EGF-like domain//Cadherin cytoplasmic region//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.2871 BP_3 206.20 2.18 4841 642928842 XP_008195585.1 1151 1.1e-122 PREDICTED: uncharacterized protein LOC657427 isoform X1 [Tribolium castaneum] 642928841 XM_008197363.1 271 4.95106e-137 PREDICTED: Tribolium castaneum uncharacterized LOC657427 (LOC657427), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF00951//PF01284 Arterivirus GL envelope glycoprotein//Membrane-associating domain -- -- -- -- GO:0019031//GO:0016020 viral envelope//membrane -- -- Cluster-8309.28711 BP_3 40.86 0.59 3615 91078858 XP_972061.1 1822 1.3e-200 PREDICTED: putative serine protease K12H4.7 [Tribolium castaneum] 642916112 XM_966968.2 67 9.32699e-24 PREDICTED: Tribolium castaneum putative serine protease K12H4.7 (LOC660762), mRNA -- -- -- -- P90893 781 2.6e-81 Putative serine protease F56F10.1 OS=Caenorhabditis elegans GN=F56F10.1 PE=1 SV=2 PF09138//PF05577 Urm1 (Ubiquitin related modifier)//Serine carboxypeptidase S28 GO:0006508//GO:0034227 proteolysis//tRNA thio-modification GO:0008236 serine-type peptidase activity GO:0005737 cytoplasm KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.28712 BP_3 658.31 10.91 3201 91078858 XP_972061.1 1822 1.1e-200 PREDICTED: putative serine protease K12H4.7 [Tribolium castaneum] 642916112 XM_966968.2 67 8.24809e-24 PREDICTED: Tribolium castaneum putative serine protease K12H4.7 (LOC660762), mRNA -- -- -- -- P90893 781 2.3e-81 Putative serine protease F56F10.1 OS=Caenorhabditis elegans GN=F56F10.1 PE=1 SV=2 PF02080//PF05577//PF09138 TrkA-C domain//Serine carboxypeptidase S28//Urm1 (Ubiquitin related modifier) GO:0034227//GO:0006508//GO:0006812//GO:0006813 tRNA thio-modification//proteolysis//cation transport//potassium ion transport GO:0008324//GO:0008236 cation transmembrane transporter activity//serine-type peptidase activity GO:0005737 cytoplasm KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.28713 BP_3 75.00 21.82 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28715 BP_3 828.75 19.04 2390 642939327 XP_008200406.1 1139 1.3e-121 PREDICTED: DCN1-like protein 4 [Tribolium castaneum] 642939326 XM_008202184.1 281 6.70136e-143 PREDICTED: Tribolium castaneum DCN1-like protein 4 (LOC657768), mRNA K17824 DCUN1D4_5 DCN1-like protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K17824 Q5RHX6 783 1.0e-81 DCN1-like protein 4 OS=Danio rerio GN=dcun1d4 PE=3 SV=2 PF06268 Fascin domain -- -- GO:0051015//GO:0030674 actin filament binding//protein binding, bridging -- -- KOG3962 Predicted actin-bundling protein Cluster-8309.28716 BP_3 136.00 14.37 748 478254809 ENN75045.1 438 7.9e-41 hypothetical protein YQE_08360, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1LZ79 159 7.3e-10 Gem-associated protein 8 OS=Bos taurus GN=GEMIN8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28717 BP_3 1600.51 12.27 6578 589060792 AHK26789.1 2872 0.0e+00 pyruvate carboxylase, partial [Epicauta chinensis] 817070062 XM_012401613.1 189 2.58262e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 2262 8.9e-253 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF02786//PF07478//PF02655//PF05896//PF00682 Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus//ATP-grasp domain//Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//HMGL-like GO:0009252//GO:0055114//GO:0006814//GO:0006118//GO:0046436 peptidoglycan biosynthetic process//oxidation-reduction process//sodium ion transport//obsolete electron transport//D-alanine metabolic process GO:0046872//GO:0008716//GO:0016655//GO:0003824//GO:0005524 metal ion binding//D-alanine-D-alanine ligase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//catalytic activity//ATP binding -- -- KOG0369 Pyruvate carboxylase Cluster-8309.28718 BP_3 376.29 4.33 4480 642916588 XP_008191804.1 545 1.9e-52 PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum]>gi|642916590|ref|XP_008191810.1| PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12597 AIR1_2 protein AIR1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12597 A1L2T6 239 2.3e-18 Zinc finger CCHC domain-containing protein 7 OS=Xenopus laevis GN=zcchc7 PE=2 SV=2 PF06331 Transcription factor TFIIH complex subunit Tfb5 GO:0006289//GO:0006355 nucleotide-excision repair//regulation of transcription, DNA-templated -- -- GO:0000439 core TFIIH complex KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.28719 BP_3 130.00 4.56 1666 642916638 XP_970958.2 1851 2.5e-204 PREDICTED: glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02434 gatB, PET112 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02434 B0W3H3 1386 8.6e-152 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Culex quinquefasciatus GN=CPIJ001717 PE=3 SV=1 PF02637//PF02934 GatB domain//GatB/GatE catalytic domain -- -- GO:0016884//GO:0016874 carbon-nitrogen ligase activity, with glutamine as amido-N-donor//ligase activity -- -- KOG2438 Glutamyl-tRNA amidotransferase subunit B Cluster-8309.2872 BP_3 9.00 0.35 1535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28722 BP_3 43.79 2.34 1192 270004583 EFA01031.1 622 5.8e-62 hypothetical protein TcasGA2_TC003947 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 503 1.5e-49 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.28724 BP_3 25.17 1.33 1206 749773946 XP_011142301.1 194 2.5e-12 PREDICTED: uncharacterized protein LOC105184888 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28725 BP_3 10.05 0.87 848 749773946 XP_011142301.1 194 1.8e-12 PREDICTED: uncharacterized protein LOC105184888 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28726 BP_3 240.17 8.52 1651 815820103 XP_012231256.1 188 1.7e-11 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13851//PF05485//PF04977 Growth-arrest specific micro-tubule binding//THAP domain//Septum formation initiator GO:0007049//GO:0048870 cell cycle//cell motility GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.28727 BP_3 13.88 0.55 1519 332376773 AEE63526.1 619 1.6e-61 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02884 RP-L19, MRPL19, rplS large subunit ribosomal protein L19 http://www.genome.jp/dbget-bin/www_bget?ko:K02884 Q9VHN6 563 2.1e-56 39S ribosomal protein L19, mitochondrial OS=Drosophila melanogaster GN=mRpL19 PE=2 SV=1 PF01245 Ribosomal protein L19 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1698 Mitochondrial/chloroplast ribosomal protein L19 Cluster-8309.28729 BP_3 5192.66 67.20 4016 270012816 EFA09264.1 1894 6.2e-209 matrix metalloproteinase 2 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q3U435 485 6.2e-47 Matrix metalloproteinase-25 OS=Mus musculus GN=Mmp25 PE=2 SV=1 PF02691//PF00413//PF10462//PF07998//PF01400 Vacuolating cyotoxin//Matrixin//Peptidase M66//Peptidase family M54//Astacin (Peptidase family M12A) GO:0009405//GO:0006508 pathogenesis//proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012//GO:0005576 extracellular matrix//extracellular region -- -- Cluster-8309.28731 BP_3 117.00 15.03 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28732 BP_3 360.05 7.33 2660 642914785 XP_008190351.1 1898 1.4e-209 PREDICTED: LIM domain-binding protein 2 isoform X6 [Tribolium castaneum] 642914784 XM_008192129.1 927 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X6, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 Q9W676 1309 1.2e-142 LIM domain-binding protein 2 OS=Gallus gallus GN=LDB2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.28733 BP_3 70.82 1.10 3400 642914785 XP_008190351.1 1898 1.8e-209 PREDICTED: LIM domain-binding protein 2 isoform X6 [Tribolium castaneum] 642914784 XM_008192129.1 947 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X6, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 Q9W676 1309 1.5e-142 LIM domain-binding protein 2 OS=Gallus gallus GN=LDB2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.28734 BP_3 750.41 5.77 6562 91077990 XP_968879.1 2384 1.5e-265 PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp3 [Tribolium castaneum]>gi|270001423|gb|EEZ97870.1| hypothetical protein TcasGA2_TC000245 [Tribolium castaneum] 642914786 XM_008192130.1 262 6.76895e-132 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X7, mRNA K12843 PRPF3, PRP3 U4/U6 small nuclear ribonucleoprotein PRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K12843 Q922U1 1295 1.2e-140 U4/U6 small nuclear ribonucleoprotein Prp3 OS=Mus musculus GN=Prpf3 PE=2 SV=1 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2769 Putative u4/u6 small nuclear ribonucleoprotein Cluster-8309.28736 BP_3 40.81 0.46 4612 546678917 ERL89455.1 261 1.6e-19 hypothetical protein D910_06822 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 138 1.2e-06 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF08996//PF03604//PF13465//PF00111//PF13912//PF01363//PF16622 Zinc finger, C2H2 type//DNA Polymerase alpha zinc finger//DNA directed RNA polymerase, 7 kDa subunit//Zinc-finger double domain//2Fe-2S iron-sulfur cluster binding domain//C2H2-type zinc finger//FYVE zinc finger//zinc-finger C2H2-type GO:0006260//GO:0006206//GO:0006118//GO:0006351//GO:0006144 DNA replication//pyrimidine nucleobase metabolic process//obsolete electron transport//transcription, DNA-templated//purine nucleobase metabolic process GO:0051536//GO:0009055//GO:0046872//GO:0001882//GO:0003677//GO:0003899//GO:0003887 iron-sulfur cluster binding//electron carrier activity//metal ion binding//nucleoside binding//DNA binding//DNA-directed RNA polymerase activity//DNA-directed DNA polymerase activity GO:0005730//GO:0042575 nucleolus//DNA polymerase complex -- -- Cluster-8309.28737 BP_3 16.25 0.66 1481 642930342 XP_008196356.1 862 1.1e-89 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 273 1.15217e-138 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- Q6PH08 136 6.7e-07 ERC protein 2 OS=Mus musculus GN=Erc2 PE=2 SV=2 PF10473//PF10174 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//RIM-binding protein of the cytomatrix active zone -- -- GO:0042803//GO:0045502//GO:0008134 protein homodimerization activity//dynein binding//transcription factor binding GO:0030286//GO:0048786//GO:0005667 dynein complex//presynaptic active zone//transcription factor complex -- -- Cluster-8309.28738 BP_3 17.62 3.26 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28739 BP_3 816.93 21.61 2114 646700389 KDR10550.1 1766 2.3e-194 V-type proton ATPase subunit C [Zootermopsis nevadensis] 571527272 XM_006562096.1 219 1.72837e-108 PREDICTED: Apis mellifera vacuolar H[+] ATPase 44kD C subunit (Vha44), transcript variant X2, mRNA K02148 ATPeV1C, ATP6C V-type H+-transporting ATPase subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K02148 Q9U5N1 1628 9.4e-180 V-type proton ATPase subunit C OS=Manduca sexta PE=2 SV=1 PF04513//PF03223//PF04799 Baculovirus polyhedron envelope protein, PEP, C terminus//V-ATPase subunit C//fzo-like conserved region GO:0015991//GO:0015992//GO:0008053 ATP hydrolysis coupled proton transport//proton transport//mitochondrial fusion GO:0003924//GO:0005198//GO:0015078 GTPase activity//structural molecule activity//hydrogen ion transmembrane transporter activity GO:0019031//GO:0033180//GO:0019028//GO:0016021//GO:0005741 viral envelope//proton-transporting V-type ATPase, V1 domain//viral capsid//integral component of membrane//mitochondrial outer membrane KOG2909 Vacuolar H+-ATPase V1 sector, subunit C Cluster-8309.28741 BP_3 37.00 1.44 1531 642924897 XP_008194088.1 558 2.0e-54 PREDICTED: laminin subunit alpha-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 Q2QI47 479 1.2e-46 Usherin OS=Mus musculus GN=Ush2A PE=1 SV=2 PF00424//PF00806 REV protein (anti-repression trans-activator protein)//Pumilio-family RNA binding repeat GO:0006355 regulation of transcription, DNA-templated GO:0003723//GO:0003700 RNA binding//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.28742 BP_3 24.07 0.63 2124 642918767 XP_008191575.1 728 5.3e-74 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9Y251 380 4.9e-35 Heparanase OS=Homo sapiens GN=HPSE PE=1 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.28743 BP_3 503.09 17.83 1652 91090466 XP_966605.1 1746 3.7e-192 PREDICTED: macrophage erythroblast attacher [Tribolium castaneum] -- -- -- -- -- K18624 MAEA, EMP macrophage erythroblast attacher http://www.genome.jp/dbget-bin/www_bget?ko:K18624 Q5F398 1163 6.1e-126 Macrophage erythroblast attacher OS=Gallus gallus GN=MAEA PE=2 SV=1 PF08513//PF06291 LisH//Bor protein -- -- GO:0005515 protein binding GO:0009279 cell outer membrane KOG0396 Uncharacterized conserved protein Cluster-8309.28745 BP_3 1.67 9.92 258 642913374 XP_008195452.1 423 1.5e-39 PREDICTED: uncharacterized protein LOC657396 isoform X1 [Tribolium castaneum]>gi|642913376|ref|XP_008195457.1| PREDICTED: uncharacterized protein LOC657396 isoform X1 [Tribolium castaneum] 195480065 XM_002101088.1 121 5.62518e-55 Drosophila yakuba GE15793 (Dyak\GE15793), partial mRNA -- -- -- -- -- -- -- -- PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.28747 BP_3 180.00 3.79 2582 642920873 XP_008192595.1 2587 1.8e-289 PREDICTED: protein turtle isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q967D7 903 1.3e-95 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF16656//PF00041//PF13895 Tissue factor//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-8309.28749 BP_3 36.00 0.45 4169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28750 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28752 BP_3 2027.20 54.31 2091 478262708 ENN81255.1 592 3.1e-58 hypothetical protein YQE_02349, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1KKR9 422 6.5e-40 Protein lunapark-B OS=Takifugu rubripes GN=lnpb PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2846 Predicted membrane protein Cluster-8309.28755 BP_3 48.77 1.64 1721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2876 BP_3 430.28 77.57 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28760 BP_3 76.42 1.10 3636 642924494 XP_008194318.1 1947 4.0e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 9.1e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.28761 BP_3 24.15 0.37 3453 642924494 XP_008194318.1 1947 3.8e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 8.6e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.28762 BP_3 1620.82 36.03 2460 731275672 XP_010606850.1 328 1.5e-27 PREDICTED: macrophage mannose receptor 1-like [Fukomys damarensis]>gi|676265405|gb|KFO21624.1| Macrophage mannose receptor 1 [Fukomys damarensis] -- -- -- -- -- -- -- -- -- P22897 252 4.0e-20 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF02944//PF07740 BESS motif//Ion channel inhibitory toxin GO:0006810//GO:0009405 transport//pathogenesis GO:0003677//GO:0008200 DNA binding//ion channel inhibitor activity GO:0005576 extracellular region KOG4297 C-type lectin Cluster-8309.28763 BP_3 291.79 2.89 5166 642934648 XP_972393.2 2127 7.7e-236 PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934650|ref|XP_008197751.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934652|ref|XP_008197752.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96NJ5 550 2.3e-54 Kelch-like protein 32 OS=Homo sapiens GN=KLHL32 PE=2 SV=2 PF07646//PF00651//PF01344 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28766 BP_3 71.47 1.19 3193 91088135 XP_970927.1 2643 7.0e-296 PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum]>gi|642931216|ref|XP_008196487.1| PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum] -- -- -- -- -- K14015 NPLOC4, NPL4 nuclear protein localization protein 4 homolog http://www.genome.jp/dbget-bin/www_bget?ko:K14015 Q9VBP9 1974 1.1e-219 Nuclear protein localization protein 4 homolog OS=Drosophila melanogaster GN=Npl4 PE=1 SV=3 PF02565//PF15957//PF00641 Recombination protein O C terminal//Commissureless//Zn-finger in Ran binding protein and others GO:0006310//GO:0007411//GO:0006281 DNA recombination//axon guidance//DNA repair GO:0008270 zinc ion binding -- -- KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4) Cluster-8309.28769 BP_3 306.00 14.83 1286 91085985 XP_972080.1 729 2.5e-74 PREDICTED: RNA-binding motif protein, X-linked 2 [Tribolium castaneum]>gi|270010180|gb|EFA06628.1| hypothetical protein TcasGA2_TC009547 [Tribolium castaneum] -- -- -- -- -- K13107 RBMX2, IST3 RNA-binding motif protein, X-linked 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13107 B0BN49 523 7.8e-52 RNA-binding motif protein, X-linked 2 OS=Rattus norvegicus GN=Rbmx2 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0126 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.28773 BP_3 216.00 4.71 2503 189233729 XP_970857.2 1013 5.6e-107 PREDICTED: protein giant-lens [Tribolium castaneum] -- -- -- -- -- K02104 ARGOS giant-lens protein precursor (argos protein) http://www.genome.jp/dbget-bin/www_bget?ko:K02104 Q00805 564 2.7e-56 Protein giant-lens OS=Drosophila melanogaster GN=aos PE=1 SV=2 PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.28774 BP_3 1270.98 44.84 1658 91095259 XP_973683.1 1207 1.2e-129 PREDICTED: senecionine N-oxygenase [Tribolium castaneum]>gi|270017047|gb|EFA13493.1| hypothetical protein TcasGA2_TC016303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MP06 524 7.7e-52 Senecionine N-oxygenase OS=Tyria jacobaeae GN=sno1 PE=1 SV=1 PF01266//PF05834//PF00070//PF01210//PF01134//PF00743//PF07992//PF01494//PF02789//PF01593 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Glucose inhibited division protein A//Flavin-binding monooxygenase-like//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Cytosol aminopeptidase family, N-terminal domain//Flavin containing amine oxidoreductase GO:0046168//GO:0006508//GO:0016117//GO:0008033//GO:0055114 glycerol-3-phosphate catabolic process//proteolysis//carotenoid biosynthetic process//tRNA processing//oxidation-reduction process GO:0004499//GO:0050661//GO:0071949//GO:0016705//GO:0016491//GO:0016616//GO:0051287//GO:0050660//GO:0004177 N,N-dimethylaniline monooxygenase activity//NADP binding//FAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//flavin adenine dinucleotide binding//aminopeptidase activity GO:0005622 intracellular -- -- Cluster-8309.28775 BP_3 1737.84 24.75 3676 91095259 XP_973683.1 1213 5.3e-130 PREDICTED: senecionine N-oxygenase [Tribolium castaneum]>gi|270017047|gb|EFA13493.1| hypothetical protein TcasGA2_TC016303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MP06 479 2.8e-46 Senecionine N-oxygenase OS=Tyria jacobaeae GN=sno1 PE=1 SV=1 PF02789//PF00070//PF01593//PF01266//PF00743//PF05834//PF07992 Cytosol aminopeptidase family, N-terminal domain//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Flavin-binding monooxygenase-like//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0006508//GO:0016117 oxidation-reduction process//proteolysis//carotenoid biosynthetic process GO:0050660//GO:0004177//GO:0016491//GO:0004499//GO:0050661//GO:0016705 flavin adenine dinucleotide binding//aminopeptidase activity//oxidoreductase activity//N,N-dimethylaniline monooxygenase activity//NADP binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005622 intracellular -- -- Cluster-8309.28776 BP_3 10.00 1.35 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28777 BP_3 24.00 7.03 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28779 BP_3 694.78 15.83 2407 91076592 XP_968333.1 932 1.3e-97 PREDICTED: charged multivesicular body protein 5 [Tribolium castaneum]>gi|270002380|gb|EEZ98827.1| hypothetical protein TcasGA2_TC004434 [Tribolium castaneum] 642912650 XM_963240.2 181 2.6241e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K12198 CHMP5, VPS60 charged multivesicular body protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12198 Q9VVI9 706 8.8e-73 Charged multivesicular body protein 5 OS=Drosophila melanogaster GN=Vps60 PE=1 SV=2 PF07544//PF00462//PF01920//PF03357//PF04871//PF04632//PF16326//PF04111//PF05531 RNA polymerase II transcription mediator complex subunit 9//Glutaredoxin//Prefoldin subunit//Snf7//Uso1 / p115 like vesicle tethering protein, C terminal region//Fusaric acid resistance protein family//ABC transporter C-terminal domain//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein GO:0006810//GO:0006886//GO:0006914//GO:0006357//GO:0006118//GO:0015031//GO:0007034//GO:0006457//GO:0045454 transport//intracellular protein transport//autophagy//regulation of transcription from RNA polymerase II promoter//obsolete electron transport//protein transport//vacuolar transport//protein folding//cell redox homeostasis GO:0008565//GO:0051082//GO:0003677//GO:0001104//GO:0015035//GO:0009055 protein transporter activity//unfolded protein binding//DNA binding//RNA polymerase II transcription cofactor activity//protein disulfide oxidoreductase activity//electron carrier activity GO:0019028//GO:0016272//GO:0005737//GO:0005886//GO:0016592//GO:0016020 viral capsid//prefoldin complex//cytoplasm//plasma membrane//mediator complex//membrane KOG1655 Protein involved in vacuolar protein sorting Cluster-8309.28781 BP_3 4.49 0.35 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28782 BP_3 150.65 3.44 2405 189242134 XP_968235.2 1493 1.2e-162 PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 7.3e-112 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF00515//PF05118//PF13176//PF13414//PF04812//PF13181//PF05470//PF04147//PF04557//PF13174 Tetratricopeptide repeat//Aspartyl/Asparaginyl beta-hydroxylase//Tetratricopeptide repeat//TPR repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//Tetratricopeptide repeat//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Nop14-like family//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//Tetratricopeptide repeat GO:0045893//GO:0006425//GO:0006413//GO:0018193//GO:0006446 positive regulation of transcription, DNA-templated//glutaminyl-tRNA aminoacylation//translational initiation//peptidyl-amino acid modification//regulation of translational initiation GO:0000166//GO:0003743//GO:0005524//GO:0004819//GO:0031369//GO:0005515 nucleotide binding//translation initiation factor activity//ATP binding//glutamine-tRNA ligase activity//translation initiation factor binding//protein binding GO:0005737//GO:0032040//GO:0005840//GO:0005852//GO:0005634 cytoplasm//small-subunit processome//ribosome//eukaryotic translation initiation factor 3 complex//nucleus KOG3696 Aspartyl beta-hydroxylase Cluster-8309.28784 BP_3 2.01 0.83 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28785 BP_3 395.38 22.63 1134 91082333 XP_974678.1 805 3.3e-83 PREDICTED: sugar transporter SWEET1 [Tribolium castaneum]>gi|270008305|gb|EFA04753.1| hypothetical protein TcasGA2_TC030574 [Tribolium castaneum] -- -- -- -- -- K15382 SLC50A, SWEET solute carrier family 50 (sugar transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K15382 Q7JVE7 590 1.2e-59 Sugar transporter SWEET1 OS=Drosophila melanogaster GN=slv PE=1 SV=1 PF03083//PF02293 Sugar efflux transporter for intercellular exchange//AmiS/UreI family transporter GO:0006310//GO:0006810//GO:0008643 DNA recombination//transport//carbohydrate transport -- -- GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane KOG1623 Multitransmembrane protein Cluster-8309.28786 BP_3 8.53 0.34 1488 91079056 XP_975139.1 583 2.4e-57 PREDICTED: uncharacterized protein LOC664025 [Tribolium castaneum]>gi|270004195|gb|EFA00643.1| hypothetical protein TcasGA2_TC003519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28787 BP_3 103.70 2.37 2404 642915809 XP_008200087.1 1148 1.2e-122 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 466 5.9e-45 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.28789 BP_3 47.57 4.94 756 91092902 XP_971056.1 742 4.5e-76 PREDICTED: N-acetyltransferase 9-like protein [Tribolium castaneum]>gi|270003097|gb|EEZ99544.1| hypothetical protein TcasGA2_TC000126 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7SLC8 468 1.1e-45 N-acetyltransferase 9-like protein OS=Nematostella vectensis GN=nat9 PE=3 SV=1 PF13302 Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG4135 Predicted phosphoglucosamine acetyltransferase Cluster-8309.2879 BP_3 4.83 0.65 649 546677206 ERL88085.1 201 2.1e-13 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28791 BP_3 171.72 1.12 7709 805759871 XP_012153123.1 3655 0.0e+00 PREDICTED: uncharacterized protein LOC100877606 isoform X2 [Megachile rotundata] 805759873 XM_012297744.1 247 1.73502e-123 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 3.2e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF14604//PF00018//PF00621 Variant SH3 domain//SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.28792 BP_3 578.36 18.67 1785 91081985 XP_968673.1 604 1.1e-59 PREDICTED: protein LZIC [Tribolium castaneum]>gi|270007372|gb|EFA03820.1| hypothetical protein TcasGA2_TC013935 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DHH7 386 8.3e-36 Protein LZIC OS=Danio rerio GN=lzic PE=1 SV=1 PF06384//PF04632 Beta-catenin-interacting protein ICAT//Fusaric acid resistance protein family GO:0006810 transport GO:0008013 beta-catenin binding GO:0005886//GO:0016342 plasma membrane//catenin complex -- -- Cluster-8309.28795 BP_3 154.98 4.69 1885 478263077 ENN81477.1 469 5.1e-44 hypothetical protein YQE_02169, partial [Dendroctonus ponderosae]>gi|546682119|gb|ERL92100.1| hypothetical protein D910_09421 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10729 Cell division activator CedA GO:0051301 cell division GO:0003677 DNA binding -- -- -- -- Cluster-8309.28796 BP_3 2.88 0.33 714 741829858 AJA91073.1 520 2.3e-50 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 363 1.5e-33 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF06584//PF00067 DIRP//Cytochrome P450 GO:0006351//GO:0007049//GO:0055114 transcription, DNA-templated//cell cycle//oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding GO:0017053 transcriptional repressor complex -- -- Cluster-8309.28800 BP_3 25.10 3.98 596 642933931 XP_008197572.1 383 1.5e-34 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 141 7.1e-08 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28805 BP_3 9.98 0.42 1448 642931814 XP_008196744.1 1106 5.3e-118 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 804 2.3e-84 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.28806 BP_3 372.00 14.25 1550 91095041 XP_971778.1 1382 5.6e-150 PREDICTED: cysteine-rich with EGF-like domain protein 2 [Tribolium castaneum]>gi|270014762|gb|EFA11210.1| hypothetical protein TcasGA2_TC005174 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXF6 729 1.2e-75 Cysteine-rich with EGF-like domain protein 2 OS=Danio rerio GN=creld2 PE=2 SV=2 PF07645//PF06298 Calcium-binding EGF domain//Photosystem II protein Y (PsbY) GO:0015979 photosynthesis GO:0005509//GO:0030145 calcium ion binding//manganese ion binding GO:0016021//GO:0009523 integral component of membrane//photosystem II KOG4260 Uncharacterized conserved protein Cluster-8309.28807 BP_3 35.68 1.47 1463 91078688 XP_971079.1 929 1.8e-97 PREDICTED: pentatricopeptide repeat-containing protein 1, mitochondrial [Tribolium castaneum]>gi|270004076|gb|EFA00524.1| hypothetical protein TcasGA2_TC003389 [Tribolium castaneum] -- -- -- -- -- K17710 PTCD1 pentatricopeptide repeat domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17710 O75127 465 4.7e-45 Pentatricopeptide repeat-containing protein 1, mitochondrial OS=Homo sapiens GN=PTCD1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4197 FOG: PPR repeat Cluster-8309.28809 BP_3 1283.95 17.09 3912 478251380 ENN71846.1 1036 1.9e-109 hypothetical protein YQE_11464, partial [Dendroctonus ponderosae] -- -- -- -- -- K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 Q7ZXE9 429 1.9e-40 Testin OS=Xenopus laevis GN=tes PE=2 SV=1 PF00412//PF06297 LIM domain//PET Domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.28810 BP_3 21.66 0.64 1925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28811 BP_3 2.10 0.43 530 478250183 ENN70686.1 338 2.2e-29 hypothetical protein YQE_12631, partial [Dendroctonus ponderosae]>gi|546682381|gb|ERL92323.1| hypothetical protein D910_09640 [Dendroctonus ponderosae] -- -- -- -- -- K03952 NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28812 BP_3 58.00 9.76 578 -- -- -- -- -- 642914215 XM_968004.2 43 3.11443e-11 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC661872), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28813 BP_3 4170.36 105.34 2200 269995911 NP_001161778.1 1536 1.1e-167 yellow-c precursor [Tribolium castaneum]>gi|270014214|gb|EFA10662.1| hypothetical protein TcasGA2_TC016299 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02437 819 6.3e-86 Protein yellow OS=Drosophila subobscura GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28814 BP_3 63.76 0.53 6122 642935129 XP_008197899.1 458 3.1e-42 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- K14651 TAF15, NPL3 transcription initiation factor TFIID subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14651 Q27294 374 7.0e-34 RNA-binding protein cabeza OS=Drosophila melanogaster GN=caz PE=2 SV=2 PF00641//PF00076 Zn-finger in Ran binding protein and others//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG1995 Conserved Zn-finger protein Cluster-8309.28817 BP_3 191.00 43.34 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28818 BP_3 985.74 8.61 5812 478257262 ENN77425.1 4009 0.0e+00 hypothetical protein YQE_06250, partial [Dendroctonus ponderosae]>gi|546683816|gb|ERL93569.1| hypothetical protein D910_10857 [Dendroctonus ponderosae] 801384853 XM_012200272.1 35 9.25356e-06 PREDICTED: Atta cephalotes tyrosine-protein phosphatase non-receptor type 23 (LOC105618741), mRNA K18040 PTPN23 tyrosine-protein phosphatase non-receptor type 23 http://www.genome.jp/dbget-bin/www_bget?ko:K18040 Q6PB44 1409 6.4e-154 Tyrosine-protein phosphatase non-receptor type 23 OS=Mus musculus GN=Ptpn23 PE=1 SV=2 PF13949//PF00102//PF00782//PF04632 ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Fusaric acid resistance protein family GO:0006570//GO:0006810//GO:0006470 tyrosine metabolic process//transport//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding GO:0005886 plasma membrane KOG2220 Predicted signal transduction protein Cluster-8309.28819 BP_3 289.80 2.54 5791 478257262 ENN77425.1 4013 0.0e+00 hypothetical protein YQE_06250, partial [Dendroctonus ponderosae]>gi|546683816|gb|ERL93569.1| hypothetical protein D910_10857 [Dendroctonus ponderosae] 801384853 XM_012200272.1 35 9.21992e-06 PREDICTED: Atta cephalotes tyrosine-protein phosphatase non-receptor type 23 (LOC105618741), mRNA K18040 PTPN23 tyrosine-protein phosphatase non-receptor type 23 http://www.genome.jp/dbget-bin/www_bget?ko:K18040 Q6PB44 1409 6.4e-154 Tyrosine-protein phosphatase non-receptor type 23 OS=Mus musculus GN=Ptpn23 PE=1 SV=2 PF04632//PF00782//PF13949//PF00102 Fusaric acid resistance protein family//Dual specificity phosphatase, catalytic domain//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase GO:0006470//GO:0006570//GO:0006810 protein dephosphorylation//tyrosine metabolic process//transport GO:0008138//GO:0005515//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity GO:0005886 plasma membrane KOG2220 Predicted signal transduction protein Cluster-8309.28820 BP_3 206.51 3.77 2929 332374228 AEE62255.1 922 2.3e-96 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D3D0 225 6.4e-17 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28822 BP_3 672.35 3.23 10328 642935247 XP_008197929.1 5669 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 1017 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1750 3.3e-193 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05506//PF13443//PF16656//PF00041//PF13895 Domain of unknown function (DUF756)//Cro/C1-type HTH DNA-binding domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0016042//GO:0006771//GO:0009395//GO:0019497 lipid catabolic process//riboflavin metabolic process//phospholipid catabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0043565//GO:0004629//GO:0046872//GO:0005515 acid phosphatase activity//sequence-specific DNA binding//phospholipase C activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.28823 BP_3 262.03 7.11 2069 546671283 ERL83661.1 930 1.9e-97 hypothetical protein D910_00828 [Dendroctonus ponderosae]>gi|546671285|gb|ERL83662.1| hypothetical protein D910_00829 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00637 Region in Clathrin and VPS GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport -- -- -- -- -- -- Cluster-8309.28824 BP_3 3.00 2.31 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28826 BP_3 678.96 24.25 1641 91088651 XP_974484.1 1325 2.4e-143 PREDICTED: beta-1,4-galactosyltransferase 4 [Tribolium castaneum]>gi|270012269|gb|EFA08717.1| hypothetical protein TcasGA2_TC006388 [Tribolium castaneum] -- -- -- -- -- K07968 B4GALT3 beta-1,4-galactosyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07968 Q9GUM2 694 1.5e-71 Beta-1,4-N-acetylgalactosaminyltransferase bre-4 OS=Caenorhabditis elegans GN=bre-4 PE=1 SV=1 PF04421 Mss4 protein GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.28827 BP_3 271.22 3.43 4100 91077400 XP_975316.1 3136 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X2 [Tribolium castaneum]>gi|270002116|gb|EEZ98563.1| hypothetical protein TcasGA2_TC001074 [Tribolium castaneum] 755870656 XM_005181954.2 137 1.29464e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 Q63531 2117 3.6e-236 Ribosomal protein S6 kinase alpha-1 OS=Rattus norvegicus GN=Rps6ka1 PE=1 SV=1 PF07714//PF00433//PF00069//PF06293 Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0000287//GO:0004672//GO:0004674//GO:0016773 ATP binding//magnesium ion binding//protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.28828 BP_3 73.28 1.08 3556 817209795 XP_012280960.1 2388 2.9e-266 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Orussus abietinus] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q6WQJ1 1365 5.0e-149 Sn1-specific diacylglycerol lipase alpha OS=Mus musculus GN=Dagla PE=1 SV=2 PF02411//PF01764//PF07168 MerT mercuric transport protein//Lipase (class 3)//Ureide permease GO:0071705//GO:0015694//GO:0006629 nitrogen compound transport//mercury ion transport//lipid metabolic process GO:0015097 mercury ion transmembrane transporter activity GO:0016020 membrane KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.28829 BP_3 216.78 3.10 3660 -- -- -- -- -- 642912790 XM_008203032.1 91 4.30171e-37 PREDICTED: Tribolium castaneum max-interacting protein 1-like (LOC100142502), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28830 BP_3 632.00 9.66 3445 817209795 XP_012280960.1 2392 9.6e-267 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Orussus abietinus] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q6WQJ1 1369 1.7e-149 Sn1-specific diacylglycerol lipase alpha OS=Mus musculus GN=Dagla PE=1 SV=2 PF02411//PF01764//PF07168 MerT mercuric transport protein//Lipase (class 3)//Ureide permease GO:0006629//GO:0015694//GO:0071705 lipid metabolic process//mercury ion transport//nitrogen compound transport GO:0015097 mercury ion transmembrane transporter activity GO:0016020 membrane KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.28831 BP_3 254.11 4.56 2978 817209795 XP_012280960.1 2209 1.4e-245 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Orussus abietinus] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q6WQJ1 1261 4.8e-137 Sn1-specific diacylglycerol lipase alpha OS=Mus musculus GN=Dagla PE=1 SV=2 PF02411//PF01764//PF07168 MerT mercuric transport protein//Lipase (class 3)//Ureide permease GO:0006629//GO:0071705//GO:0015694 lipid metabolic process//nitrogen compound transport//mercury ion transport GO:0015097 mercury ion transmembrane transporter activity GO:0016020 membrane KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.28833 BP_3 133.86 1.38 4952 642929898 XP_975679.2 1290 8.4e-139 PREDICTED: protein CASC3 [Tribolium castaneum] -- -- -- -- -- K07951 ARL6, BBS3 ADP-ribosylation factor-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K07951 Q5M9P8 512 5.6e-50 ADP-ribosylation factor-like protein 6 OS=Danio rerio GN=arl6 PE=2 SV=1 PF01580//PF04670//PF00071//PF00503//PF01926//PF04995//PF08477//PF02421//PF00025 FtsK/SpoIIIE family//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//50S ribosome-binding GTPase//Heme exporter protein D (CcmD)//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family GO:0017004//GO:0007186//GO:0015684//GO:0007165//GO:0007264//GO:0015886 cytochrome complex assembly//G-protein coupled receptor signaling pathway//ferrous iron transport//signal transduction//small GTPase mediated signal transduction//heme transport GO:0019001//GO:0000166//GO:0031683//GO:0005524//GO:0003924//GO:0004871//GO:0005525//GO:0003677//GO:0015093 guanyl nucleotide binding//nucleotide binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//signal transducer activity//GTP binding//DNA binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.28834 BP_3 389.89 3.49 5675 91091388 XP_973447.1 1899 2.3e-209 PREDICTED: sorting nexin-29 isoform X1 [Tribolium castaneum]>gi|270014165|gb|EFA10613.1| hypothetical protein TcasGA2_TC012874 [Tribolium castaneum] -- -- -- -- -- K17935 SNX29 sorting nexin-29 http://www.genome.jp/dbget-bin/www_bget?ko:K17935 Q08DX0 463 3.1e-44 Sorting nexin-29 OS=Bos taurus GN=SNX29 PE=2 SV=1 PF00957//PF04977//PF00787 Synaptobrevin//Septum formation initiator//PX domain GO:0007049//GO:0016192 cell cycle//vesicle-mediated transport GO:0035091 phosphatidylinositol binding GO:0016021 integral component of membrane KOG4381 RUN domain-containing protein Cluster-8309.28835 BP_3 278.43 1.35 10214 642918082 XP_008193932.1 1793 8.2e-197 PREDICTED: protein disulfide-isomerase TMX3 [Tribolium castaneum] 795019206 XM_012004108.1 291 7.99005e-148 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556990 (LOC105556990), mRNA K09585 TXNDC10 thioredoxin domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09585 Q9VPF8 987 9.7e-105 Transmembrane protein 104 homolog OS=Drosophila melanogaster GN=CG5262 PE=2 SV=2 PF00085//PF01984//PF03222//PF01428//PF00400//PF02073//PF00578//PF00659//PF01216 Thioredoxin//Double-stranded DNA-binding domain//Tryptophan/tyrosine permease family//AN1-like Zinc finger//WD domain, G-beta repeat//Thermophilic metalloprotease (M29)//AhpC/TSA family//POLO box duplicated region//Calsequestrin GO:0006508//GO:0003333//GO:0045454//GO:0055114 proteolysis//amino acid transmembrane transport//cell redox homeostasis//oxidation-reduction process GO:0003677//GO:0005515//GO:0016491//GO:0004177//GO:0008270//GO:0005509//GO:0016209 DNA binding//protein binding//oxidoreductase activity//aminopeptidase activity//zinc ion binding//calcium ion binding//antioxidant activity -- -- KOG4277 Uncharacterized conserved protein, contains thioredoxin domain Cluster-8309.28836 BP_3 126.84 8.52 1009 646700481 KDR10610.1 304 3.7e-25 hypothetical protein L798_15138 [Zootermopsis nevadensis] 194893660 XM_001977880.1 36 4.34572e-07 Drosophila erecta GG19306 (Dere\GG19306), mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 -- -- -- -- PF12920 TcdA/TcdB pore forming domain GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.28837 BP_3 43.56 0.52 4303 478253163 ENN73534.1 187 5.8e-11 hypothetical protein YQE_09785, partial [Dendroctonus ponderosae] -- -- -- -- -- K09370 ISL1 insulin gene enhancer protein ISL-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09370 P61371 178 2.6e-11 Insulin gene enhancer protein ISL-1 OS=Homo sapiens GN=ISL1 PE=1 SV=1 PF02892//PF00412//PF02701//PF13465//PF05920//PF05495//PF00096//PF00046 BED zinc finger//LIM domain//Dof domain, zinc finger//Zinc-finger double domain//Homeobox KN domain//CHY zinc finger//Zinc finger, C2H2 type//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding -- -- KOG4577 Transcription factor LIM3, contains LIM and HOX domains Cluster-8309.28838 BP_3 180.85 4.37 2288 642938529 XP_967703.2 2004 6.2e-222 PREDICTED: RUN domain-containing protein 1-like [Tribolium castaneum]>gi|270015593|gb|EFA12041.1| hypothetical protein TcasGA2_TC001458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96C34 819 6.6e-86 RUN domain-containing protein 1 OS=Homo sapiens GN=RUNDC1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3759 Uncharacterized RUN domain protein Cluster-8309.28839 BP_3 177.82 9.31 1212 91086565 XP_967047.1 816 1.9e-84 PREDICTED: zinc finger protein-like 1 [Tribolium castaneum]>gi|270009770|gb|EFA06218.1| hypothetical protein TcasGA2_TC009067 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VFM0 368 6.9e-34 Zinc finger protein-like 1 OS=Xenopus tropicalis GN=zfpl1 PE=2 SV=1 PF13639//PF00628//PF00643 Ring finger domain//PHD-finger//B-box zinc finger -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005622 intracellular KOG3970 Predicted E3 ubiquitin ligase Cluster-8309.2884 BP_3 14.52 1.17 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28840 BP_3 2.00 0.84 405 270005976 EFA02424.1 428 6.1e-40 hypothetical protein TcasGA2_TC008109 [Tribolium castaneum] -- -- -- -- -- K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q27802 268 9.0e-23 Cytoplasmic dynein 2 heavy chain 1 OS=Tripneustes gratilla GN=DYH1B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3595 Dyneins, heavy chain Cluster-8309.28841 BP_3 41.00 2.60 1052 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28842 BP_3 201.00 10.16 1245 91089781 XP_967683.1 889 6.6e-93 PREDICTED: 39S ribosomal protein L16, mitochondrial [Tribolium castaneum]>gi|91094701|ref|XP_969519.1| PREDICTED: 39S ribosomal protein L16, mitochondrial [Tribolium castaneum]>gi|270013618|gb|EFA10066.1| hypothetical protein TcasGA2_TC012240 [Tribolium castaneum]>gi|270016519|gb|EFA12965.1| hypothetical protein TcasGA2_TC001416 [Tribolium castaneum] -- -- -- -- -- K02878 RP-L16, MRPL16, rplP large subunit ribosomal protein L16 http://www.genome.jp/dbget-bin/www_bget?ko:K02878 Q9NX20 493 2.3e-48 39S ribosomal protein L16, mitochondrial OS=Homo sapiens GN=MRPL16 PE=1 SV=1 PF00252//PF02297 Ribosomal protein L16p/L10e//Cytochrome oxidase c subunit VIb GO:0006412//GO:0006123//GO:0042254//GO:0015992 translation//mitochondrial electron transport, cytochrome c to oxygen//ribosome biogenesis//proton transport GO:0004129//GO:0019843//GO:0003735 cytochrome-c oxidase activity//rRNA binding//structural constituent of ribosome GO:0045277//GO:0005739//GO:0005840 respiratory chain complex IV//mitochondrion//ribosome KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.28844 BP_3 14.96 0.35 2358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28845 BP_3 730.00 69.50 798 91080375 XP_975028.1 563 2.7e-55 PREDICTED: single-stranded DNA-binding protein, mitochondrial [Tribolium castaneum]>gi|270005728|gb|EFA02176.1| hypothetical protein TcasGA2_TC007832 [Tribolium castaneum] -- -- -- -- -- K03111 ssb single-strand DNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03111 P54622 407 1.4e-38 Single-stranded DNA-binding protein, mitochondrial OS=Drosophila melanogaster GN=mtSSB PE=1 SV=2 PF00436 Single-strand binding protein family GO:0006260 DNA replication GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.28848 BP_3 128.36 0.71 8972 242018392 XP_002429661.1 599 2.0e-58 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q80W31 563 1.2e-55 Zinc finger protein 569 OS=Mus musculus GN=Znf569 PE=2 SV=2 PF13465//PF12937//PF09174//PF01363//PF13912//PF00412//PF00320//PF00646//PF05191//PF16622//PF00096//PF01155 Zinc-finger double domain//F-box-like//Maf1 regulator//FYVE zinc finger//C2H2-type zinc finger//LIM domain//GATA zinc finger//F-box domain//Adenylate kinase, active site lid//zinc-finger C2H2-type//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006144//GO:0046034//GO:0016480//GO:0006464//GO:0006355 purine nucleobase metabolic process//ATP metabolic process//negative regulation of transcription from RNA polymerase III promoter//cellular protein modification process//regulation of transcription, DNA-templated GO:0016151//GO:0005515//GO:0003700//GO:0046872//GO:0004017//GO:0008270//GO:0043565 nickel cation binding//protein binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//adenylate kinase activity//zinc ion binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.28851 BP_3 17.00 0.58 1702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28853 BP_3 13.93 0.46 1747 642919618 XP_008191942.1 923 1.1e-96 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4V920 522 1.4e-51 Protein kinase C and casein kinase substrate in neurons protein 1 OS=Danio rerio GN=pacsin1b PE=1 SV=1 PF00303//PF02173//PF08397 Thymidylate synthase//pKID domain//IRSp53/MIM homology domain GO:0006206//GO:0007009//GO:0006355//GO:0006231 pyrimidine nucleobase metabolic process//plasma membrane organization//regulation of transcription, DNA-templated//dTMP biosynthetic process GO:0005515//GO:0004799 protein binding//thymidylate synthase activity -- -- KOG2856 Adaptor protein PACSIN Cluster-8309.28854 BP_3 162.78 7.16 1388 642911402 XP_972355.3 1344 1.3e-145 PREDICTED: probable G-protein coupled receptor CG31760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKA4 347 2.1e-31 Probable G-protein coupled receptor CG31760 OS=Drosophila melanogaster GN=CG31760 PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.28855 BP_3 89.40 1.66 2892 338224398 AEI88080.1 332 6.0e-28 midline fasciclin [Scylla paramamosain] 338224397 HM217842.1 193 6.741e-94 Scylla paramamosain isolate 1 midline fasciclin mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28857 BP_3 75.49 0.68 5612 91095029 XP_966439.1 766 5.5e-78 PREDICTED: ubiquitin-conjugating enzyme E2 H [Tribolium castaneum]>gi|270014763|gb|EFA11211.1| hypothetical protein TcasGA2_TC005175 [Tribolium castaneum] 462332992 APGK01039128.1 63 2.43159e-21 Dendroctonus ponderosae Seq01039138, whole genome shotgun sequence K10576 UBE2H, UBC8 ubiquitin-conjugating enzyme E2 H http://www.genome.jp/dbget-bin/www_bget?ko:K10576 Q32LN1 669 4.0e-68 Ubiquitin-conjugating enzyme E2 H OS=Bos taurus GN=UBE2H PE=2 SV=1 PF05426 Alginate lyase -- -- GO:0005524//GO:0016881//GO:0016829 ATP binding//acid-amino acid ligase activity//lyase activity GO:0042597 periplasmic space KOG0416 Ubiquitin-protein ligase Cluster-8309.28858 BP_3 198.27 44.77 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2886 BP_3 46.06 2.38 1224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363//PF07776 FYVE zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.28860 BP_3 230.55 5.12 2462 642919569 XP_008191926.1 1099 5.9e-117 PREDICTED: protein angel homolog 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q5VTE6 613 5.5e-62 Protein angel homolog 2 OS=Homo sapiens GN=ANGEL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.28862 BP_3 24.41 0.45 2878 478251404 ENN71870.1 492 1.7e-46 hypothetical protein YQE_11485, partial [Dendroctonus ponderosae] 449102215 JX081307.1 150 5.37227e-70 Pleurobrachia bachei dynein light chain-2 mRNA, complete cds K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q78P75 465 9.3e-45 Dynein light chain 2, cytoplasmic OS=Rattus norvegicus GN=Dynll2 PE=1 SV=1 PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.28863 BP_3 1254.53 12.33 5197 270013807 EFA10255.1 2967 0.0e+00 hypothetical protein TcasGA2_TC012455 [Tribolium castaneum] -- -- -- -- -- K04648 DCTN1 dynactin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04648 P13496 1855 1.1e-205 Dynactin subunit 1 OS=Drosophila melanogaster GN=Gl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0971 Microtubule-associated protein dynactin DCTN1/Glued Cluster-8309.28864 BP_3 1802.27 91.51 1241 91081359 XP_971395.1 1355 6.1e-147 PREDICTED: tumor suppressor candidate 3 [Tribolium castaneum]>gi|270005188|gb|EFA01636.1| hypothetical protein TcasGA2_TC007206 [Tribolium castaneum] 571501133 XM_395605.5 180 4.79855e-87 PREDICTED: Apis mellifera magnesium transporter protein 1-like (LOC412141), mRNA K12669 OST3, OST6 oligosaccharyltransferase complex subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K12669 Q8BTV1 1013 1.1e-108 Tumor suppressor candidate 3 OS=Mus musculus GN=Tusc3 PE=2 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2603 Oligosaccharyltransferase, gamma subunit Cluster-8309.28865 BP_3 34.00 0.41 4259 642922447 XP_008193174.1 2066 7.5e-229 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0051536//GO:0009055 iron-sulfur cluster binding//electron carrier activity -- -- -- -- Cluster-8309.28866 BP_3 638.93 14.66 2392 270001539 EEZ97986.1 2022 5.3e-224 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 5.14831e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1093 1.2e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.28868 BP_3 14.54 8.72 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28869 BP_3 8.46 4.80 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28871 BP_3 366.96 2.80 6611 642919657 XP_008192010.1 2486 2.3e-277 PREDICTED: kinesin light chain isoform X2 [Tribolium castaneum]>gi|270005876|gb|EFA02324.1| hypothetical protein TcasGA2_TC007992 [Tribolium castaneum] 817205684 XM_012423337.1 333 2.31786e-171 PREDICTED: Orussus abietinus kinesin light chain (LOC105698786), transcript variant X2, mRNA K10407 KLC kinesin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10407 P46824 1708 1.6e-188 Kinesin light chain OS=Drosophila melanogaster GN=Klc PE=1 SV=1 PF00637//PF13414//PF11365//PF13176//PF03836//PF00515//PF13374//PF13174//PF01239//PF13181//PF06156 Region in Clathrin and VPS//TPR repeat//Protein of unknown function (DUF3166)//Tetratricopeptide repeat//RasGAP C-terminus//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Protein prenyltransferase alpha subunit repeat//Tetratricopeptide repeat//Protein of unknown function (DUF972) GO:0007264//GO:0006260//GO:0007017//GO:0006886//GO:0016192//GO:0018342//GO:0010506 small GTPase mediated signal transduction//DNA replication//microtubule-based process//intracellular protein transport//vesicle-mediated transport//protein prenylation//regulation of autophagy GO:0008318//GO:0003777//GO:0005515//GO:0005096 protein prenyltransferase activity//microtubule motor activity//protein binding//GTPase activator activity GO:0005615//GO:0005871//GO:0005874 extracellular space//kinesin complex//microtubule KOG1840 Kinesin light chain Cluster-8309.28873 BP_3 5444.62 34.31 7941 642924213 XP_972838.2 5278 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum] 807042282 XM_004536355.2 42 1.62597e-09 PREDICTED: Ceratitis capitata GPI transamidase component PIG-T (LOC101449963), mRNA K06530 CD109 CD109 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06530 Q6YHK3 1504 8.5e-165 CD109 antigen OS=Homo sapiens GN=CD109 PE=1 SV=2 PF04113//PF00432//PF00207//PF07678//PF06756//PF01835//PF07677 Gpi16 subunit, GPI transamidase component//Prenyltransferase and squalene oxidase repeat//Alpha-2-macroglobulin family//A-macroglobulin complement component//Chorion protein S19 C-terminal//MG2 domain//A-macroglobulin receptor GO:0016255//GO:0007275 attachment of GPI anchor to protein//multicellular organismal development GO:0004866//GO:0003824 endopeptidase inhibitor activity//catalytic activity GO:0042600//GO:0042765//GO:0005615//GO:0005576 chorion//GPI-anchor transamidase complex//extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.28875 BP_3 153.80 3.41 2467 642919825 XP_008192085.1 297 5.8e-24 PREDICTED: uncharacterized protein LOC103312661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.28876 BP_3 612.05 8.28 3854 642922650 XP_008193261.1 2300 5.0e-256 PREDICTED: coiled-coil and C2 domain-containing protein 1-like isoform X2 [Tribolium castaneum]>gi|270007151|gb|EFA03599.1| hypothetical protein TcasGA2_TC013686 [Tribolium castaneum] -- -- -- -- -- K18260 CC2D1 coiled-coil and C2 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18260 Q29M42 1660 3.3e-183 Coiled-coil and C2 domain-containing protein 1-like OS=Drosophila pseudoobscura pseudoobscura GN=GA18377 PE=3 SV=2 PF00168//PF04097//PF00711 C2 domain//Nup93/Nic96//Beta defensin GO:0006952//GO:0006810 defense response//transport GO:0005515 protein binding GO:0005576//GO:0005643 extracellular region//nuclear pore KOG3837 Uncharacterized conserved protein, contains DM14 and C2 domains Cluster-8309.28877 BP_3 61.95 0.46 6759 642932607 XP_008196920.1 1408 2.4e-152 PREDICTED: slowpoke-binding protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q8IPH9 476 1.2e-45 Slowpoke-binding protein OS=Drosophila melanogaster GN=Slob PE=1 SV=2 PF01799 [2Fe-2S] binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.28878 BP_3 98.91 3.73 1570 642932605 XP_008196919.1 1550 1.9e-169 PREDICTED: slowpoke-binding protein isoform X3 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q8IPH9 524 7.3e-52 Slowpoke-binding protein OS=Drosophila melanogaster GN=Slob PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2888 BP_3 5.00 0.42 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28881 BP_3 137.72 17.98 661 91089491 XP_969723.1 538 1.8e-52 PREDICTED: U6 snRNA-associated Sm-like protein LSm7 [Tribolium castaneum] -- -- -- -- -- K12626 LSM7 U6 snRNA-associated Sm-like protein LSm7 http://www.genome.jp/dbget-bin/www_bget?ko:K12626 Q9UK45 433 1.1e-41 U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens GN=LSM7 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1781 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.28882 BP_3 70.41 0.83 4384 642931601 XP_008196651.1 2197 5.0e-244 PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum]>gi|642931603|ref|XP_008196652.1| PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum] 170039524 XM_001847530.1 513 0 Culex quinquefasciatus eukaryotic translation initiation factor 2C 2, mRNA K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 1775 1.8e-196 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF03554//PF04810//PF02171 UL73 viral envelope glycoprotein//Sec23/Sec24 zinc finger//Piwi domain GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0030127//GO:0019031 COPII vesicle coat//viral envelope KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.28883 BP_3 1.00 0.33 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.28884 BP_3 496.00 11.73 2330 91076160 XP_966582.1 1288 6.7e-139 PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911736|ref|XP_008200719.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911739|ref|XP_008200720.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911741|ref|XP_008200721.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|270014726|gb|EFA11174.1| hypothetical protein TcasGA2_TC004781 [Tribolium castaneum] -- -- -- -- -- K04523 UBQLN, DSK2 ubiquilin http://www.genome.jp/dbget-bin/www_bget?ko:K04523 Q8R317 668 2.2e-68 Ubiquilin-1 OS=Mus musculus GN=Ubqln1 PE=1 SV=1 PF00240//PF03710//PF06559 Ubiquitin family//Glutamate-ammonia ligase adenylyltransferase//2'-deoxycytidine 5'-triphosphate deaminase (DCD) GO:0006206//GO:0006807//GO:0009394 pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//2'-deoxyribonucleotide metabolic process GO:0008829//GO:0008882//GO:0005515 dCTP deaminase activity//[glutamate-ammonia-ligase] adenylyltransferase activity//protein binding -- -- KOG0010 Ubiquitin-like protein Cluster-8309.28886 BP_3 146.93 1.86 4104 642911589 XP_008200663.1 794 2.3e-81 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 415 8.3e-39 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28887 BP_3 133.19 1.55 4439 642911589 XP_008200663.1 794 2.5e-81 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] 462386057 APGK01020367.1 60 8.9332e-20 Dendroctonus ponderosae Seq01020377, whole genome shotgun sequence -- -- -- -- A6MHQ4 362 1.3e-32 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28888 BP_3 431.32 4.63 4777 270010132 EFA06580.1 1966 3.3e-217 hypothetical protein TcasGA2_TC009492 [Tribolium castaneum] 795059302 XM_012017418.1 258 8.23256e-130 PREDICTED: Vollenhovia emeryi F-box/LRR-repeat protein 14 (LOC105564772), mRNA K10280 FBXL14 F-box and leucine-rich repeat protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K10280 Q8N1E6 1336 1.5e-145 F-box/LRR-repeat protein 14 OS=Homo sapiens GN=FBXL14 PE=1 SV=1 PF04091//PF00646//PF00560//PF01529//PF13516//PF13855//PF12937 Exocyst complex subunit Sec15-like//F-box domain//Leucine Rich Repeat//DHHC palmitoyltransferase//Leucine Rich repeat//Leucine rich repeat//F-box-like GO:0006904 vesicle docking involved in exocytosis GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0000145 exocyst KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.28893 BP_3 33.49 0.40 4315 642918803 XP_008191592.1 1707 3.2e-187 PREDICTED: mitochondrial import receptor subunit TOM70 [Tribolium castaneum]>gi|270005628|gb|EFA02076.1| hypothetical protein TcasGA2_TC007711 [Tribolium castaneum] -- -- -- -- -- K17768 TOM70 mitochondrial import receptor subunit TOM70 http://www.genome.jp/dbget-bin/www_bget?ko:K17768 Q75Q39 1021 4.7e-109 Mitochondrial import receptor subunit TOM70 OS=Rattus norvegicus GN=Tomm70a PE=1 SV=1 PF06888//PF13414//PF13176//PF05822//PF00515//PF13374//PF13371//PF13174//PF13181 Putative Phosphatase//TPR repeat//Tetratricopeptide repeat//Pyrimidine 5'-nucleotidase (UMPH-1)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0008152 metabolic process GO:0005515//GO:0000287//GO:0016791//GO:0008253 protein binding//magnesium ion binding//phosphatase activity//5'-nucleotidase activity GO:0005737 cytoplasm KOG1615 Phosphoserine phosphatase Cluster-8309.28895 BP_3 5.00 1.08 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28896 BP_3 1210.87 25.88 2547 91081197 XP_975607.1 1380 1.6e-149 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270005269|gb|EFA01717.1| hypothetical protein TcasGA2_TC007297 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 504 2.5e-49 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- GO:0016020 membrane KOG1304 Amino acid transporters Cluster-8309.28897 BP_3 92.00 7.36 894 642922166 XP_008193043.1 323 2.0e-27 PREDICTED: uncharacterized protein LOC103312926 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00258 134 6.9e-07 Tail-anchored protein insertion receptor WRB OS=Homo sapiens GN=WRB PE=1 SV=2 PF04420 CHD5-like protein GO:0071816 tail-anchored membrane protein insertion into ER membrane -- -- -- -- -- -- Cluster-8309.28899 BP_3 3.00 1.47 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28900 BP_3 25.90 0.80 1848 478257549 ENN77703.1 470 3.8e-44 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 169 1.2e-10 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- -- -- Cluster-8309.28904 BP_3 503.17 23.82 1310 642931818 XP_008196746.1 1127 1.8e-120 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] 551546037 XM_005760895.1 51 2.60602e-15 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 861 5.1e-91 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF00733//PF01507//PF00764//PF07722//PF02568 Asparagine synthase//Phosphoadenosine phosphosulfate reductase family//Arginosuccinate synthase//Peptidase C26//Thiamine biosynthesis protein (ThiI) GO:0006522//GO:0006541//GO:0008033//GO:0006526//GO:0008152//GO:0006529//GO:0006531//GO:0006560 alanine metabolic process//glutamine metabolic process//tRNA processing//arginine biosynthetic process//metabolic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process GO:0004066//GO:0003824//GO:0005524//GO:0004810//GO:0016787//GO:0004055 asparagine synthase (glutamine-hydrolyzing) activity//catalytic activity//ATP binding//tRNA adenylyltransferase activity//hydrolase activity//argininosuccinate synthase activity -- -- KOG1622 GMP synthase Cluster-8309.28906 BP_3 169.24 1.21 7050 189239891 XP_969420.2 6778 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Tribolium castaneum] 752863719 XM_011269923.1 159 1.31592e-74 PREDICTED: Camponotus floridanus E3 ubiquitin-protein ligase UBR3 (LOC105258579), mRNA K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 1589 1.0e-174 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF02323//PF12678//PF02207 Egg-laying hormone precursor//RING-H2 zinc finger//Putative zinc finger in N-recognin (UBR box) GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0008270//GO:0005179 zinc ion binding//hormone activity GO:0005576 extracellular region KOG1139 Predicted ubiquitin-protein ligase of the N-recognin family Cluster-8309.28907 BP_3 42.00 0.85 2661 270002150 EEZ98597.1 1422 2.2e-154 hypothetical protein TcasGA2_TC001116 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 955 1.3e-101 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728//PF13465 Glycosyl hydrolase family 20, catalytic domain//Zinc-finger double domain GO:0005975 carbohydrate metabolic process GO:0046872//GO:0004553 metal ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.28908 BP_3 347.89 4.05 4427 642929609 XP_008195902.1 1940 3.2e-214 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UNN5 797 4.5e-83 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF00240//PF09230//PF09226 Ubiquitin family//DNA fragmentation factor 40 kDa//Restriction endonuclease HincII GO:0006309//GO:0006308//GO:0009307 apoptotic DNA fragmentation//DNA catabolic process//DNA restriction-modification system GO:0005515//GO:0009036//GO:0003677//GO:0016787 protein binding//Type II site-specific deoxyribonuclease activity//DNA binding//hydrolase activity GO:0005634//GO:0005737//GO:0009359 nucleus//cytoplasm//Type II site-specific deoxyribonuclease complex KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.28909 BP_3 412.95 18.56 1364 546682999 ERL92871.1 737 3.1e-75 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28910 BP_3 395.36 3.75 5380 642920483 XP_008192370.1 2715 5.3e-304 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K03680 EIF2B4 translation initiation factor eIF-2B subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K03680 Q63186 925 7.9e-98 Translation initiation factor eIF-2B subunit delta OS=Rattus norvegicus GN=Eif2b4 PE=2 SV=1 PF00536//PF02601//PF01496//PF07647//PF01763//PF01008//PF02198 SAM domain (Sterile alpha motif)//Exonuclease VII, large subunit//V-type ATPase 116kDa subunit family//SAM domain (Sterile alpha motif)//Herpesvirus UL6 like//Initiation factor 2 subunit family//Sterile alpha motif (SAM)/Pointed domain GO:0006323//GO:0015992//GO:0006308//GO:0015991//GO:0044237 DNA packaging//proton transport//DNA catabolic process//ATP hydrolysis coupled proton transport//cellular metabolic process GO:0043565//GO:0015078//GO:0008855//GO:0005515 sequence-specific DNA binding//hydrogen ion transmembrane transporter activity//exodeoxyribonuclease VII activity//protein binding GO:0033179//GO:0009318//GO:0005634 proton-transporting V-type ATPase, V0 domain//exodeoxyribonuclease VII complex//nucleus KOG1467 Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2) Cluster-8309.28911 BP_3 75.29 1.43 2824 546682999 ERL92871.1 726 1.2e-73 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28912 BP_3 45.95 0.39 6035 91088309 XP_969421.1 1779 2.0e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 808 3.3e-84 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF02254//PF05199//PF01266//PF07992//PF00732//PF05834 TrkA-N domain//GMC oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein GO:0006813//GO:0055114//GO:0016117 potassium ion transport//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016705//GO:0016614 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.28913 BP_3 34.67 0.63 2935 189238157 XP_976123.2 1140 1.2e-121 PREDICTED: adiponectin receptor protein isoform X2 [Tribolium castaneum] 462291785 APGK01053980.1 177 5.36494e-85 Dendroctonus ponderosae Seq01053990, whole genome shotgun sequence K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 933 5.1e-99 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.28914 BP_3 44.71 0.70 3384 642925798 XP_008190328.1 1952 9.9e-216 PREDICTED: protein PAT1 homolog 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5DF93 310 1.0e-26 Protein PAT1 homolog 1 OS=Rattus norvegicus GN=Patl1 PE=2 SV=1 PF12558 ATP-binding cassette cobalt transporter -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- -- -- Cluster-8309.28915 BP_3 9373.00 173.87 2890 642920354 XP_008192311.1 338 1.2e-28 PREDICTED: uncharacterized protein LOC103312712 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28916 BP_3 16.91 0.42 2230 478257843 ENN77986.1 741 1.7e-75 hypothetical protein YQE_05661, partial [Dendroctonus ponderosae] -- -- -- -- -- K00683 QPCT glutaminyl-peptide cyclotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00683 Q9CYK2 378 8.8e-35 Glutaminyl-peptide cyclotransferase OS=Mus musculus GN=Qpct PE=1 SV=2 PF05450 Nicastrin GO:0016485 protein processing -- -- GO:0016021 integral component of membrane KOG3946 Glutaminyl cyclase Cluster-8309.28919 BP_3 1044.00 25.96 2230 642936500 XP_008198463.1 455 2.5e-42 PREDICTED: uncharacterized protein LOC103312129 [Tribolium castaneum]>gi|270014115|gb|EFA10563.1| hypothetical protein TcasGA2_TC012819 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2892 BP_3 49.21 0.70 3692 642937090 XP_008198688.1 885 5.7e-92 PREDICTED: nose resistant to fluoxetine protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 330 5.4e-29 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.28921 BP_3 226.78 9.22 1477 478259251 ENN79153.1 428 2.3e-39 hypothetical protein YQE_04339, partial [Dendroctonus ponderosae]>gi|546678413|gb|ERL89036.1| hypothetical protein D910_06414 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4MPK3 202 1.5e-14 Protein kintoun OS=Drosophila willistoni GN=Ppi20 PE=3 SV=1 PF03286 Pox virus Ag35 surface protein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.28922 BP_3 536.00 14.77 2041 478259251 ENN79153.1 1512 6.3e-165 hypothetical protein YQE_04339, partial [Dendroctonus ponderosae]>gi|546678413|gb|ERL89036.1| hypothetical protein D910_06414 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B3N9E4 1018 4.9e-109 Protein kintoun OS=Drosophila erecta GN=Ppi20 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28928 BP_3 2.00 14.04 253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28929 BP_3 84.19 0.88 4882 91086137 XP_968906.1 5668 0.0e+00 PREDICTED: sister chromatid cohesion protein PDS5 homolog B isoform X1 [Tribolium castaneum]>gi|270010223|gb|EFA06671.1| hypothetical protein TcasGA2_TC009599 [Tribolium castaneum] 170044604 XM_001849880.1 125 7.23337e-56 Culex quinquefasciatus androgen induced inhibitor of proliferation / pds5, mRNA K11267 PDS5 sister chromatid cohesion protein PDS5 http://www.genome.jp/dbget-bin/www_bget?ko:K11267 Q5F3U9 2271 6.0e-254 Sister chromatid cohesion protein PDS5 homolog B OS=Gallus gallus GN=PDS5B PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1525 Sister chromatid cohesion complex Cohesin, subunit PDS5 Cluster-8309.2893 BP_3 2188.75 47.45 2515 642937090 XP_008198688.1 1300 2.9e-140 PREDICTED: nose resistant to fluoxetine protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 385 1.5e-35 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.28930 BP_3 195.00 2.54 3992 642925248 XP_008194481.1 1349 9.7e-146 PREDICTED: lysocardiolipin acyltransferase 1-like [Tribolium castaneum] -- -- -- -- -- K13513 LCLAT1, AGPAT8 lysocardiolipin and lysophospholipid acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13513 Q6UWP7 634 3.2e-64 Lysocardiolipin acyltransferase 1 OS=Homo sapiens GN=LCLAT1 PE=1 SV=1 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.28932 BP_3 67.00 46.44 357 189238225 XP_970862.2 257 3.7e-20 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414 TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28933 BP_3 470.28 29.89 1050 189238225 XP_970862.2 508 8.5e-49 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- K11291 NASP nuclear autoantigenic sperm protein http://www.genome.jp/dbget-bin/www_bget?ko:K11291 Q02508 290 6.6e-25 Protein HGV2 OS=Halocynthia roretzi GN=HGV2 PE=2 SV=1 PF08631//PF01080//PF13181//PF13174//PF00515//PF02724//PF13414//PF13176 Meiosis protein SPO22/ZIP4 like//Presenilin//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//CDC45-like protein//TPR repeat//Tetratricopeptide repeat GO:0051321//GO:0006270 meiotic cell cycle//DNA replication initiation GO:0005515//GO:0004190 protein binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG4563 Cell cycle-regulated histone H1-binding protein Cluster-8309.28934 BP_3 403.72 12.54 1843 189238225 XP_970862.2 533 1.9e-51 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- K11291 NASP nuclear autoantigenic sperm protein http://www.genome.jp/dbget-bin/www_bget?ko:K11291 Q02508 290 1.2e-24 Protein HGV2 OS=Halocynthia roretzi GN=HGV2 PE=2 SV=1 PF00515//PF13181//PF13414//PF13174//PF13176//PF08702 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0030168 protein polymerization//signal transduction//platelet activation GO:0005515//GO:0030674//GO:0005102 protein binding//protein binding, bridging//receptor binding GO:0005577 fibrinogen complex KOG4563 Cell cycle-regulated histone H1-binding protein Cluster-8309.28936 BP_3 81.00 0.74 5590 546678918 ERL89456.1 203 1.0e-12 hypothetical protein D910_06823 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9N003 142 5.1e-07 Zinc finger protein 425 (Fragment) OS=Macaca fascicularis GN=ZNF425 PE=2 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.28937 BP_3 5.95 0.37 1064 546685593 ERL95080.1 545 4.4e-53 hypothetical protein D910_12350 [Dendroctonus ponderosae] 831293719 XM_012823057.1 42 2.12087e-10 PREDICTED: Clupea harengus cullin 2 (cul2), mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q5RCF3 413 3.7e-39 Cullin-2 OS=Pongo abelii GN=CUL2 PE=2 SV=1 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.28938 BP_3 39.66 0.67 3143 642912647 XP_008200948.1 315 6.1e-26 PREDICTED: CREB/ATF bZIP transcription factor-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00170//PF07716//PF01166//PF05791//PF01253//PF13631 bZIP transcription factor//Basic region leucine zipper//TSC-22/dip/bun family//Bacillus haemolytic enterotoxin (HBL)//Translation initiation factor SUI1//Cytochrome b(N-terminal)/b6/petB GO:0009405//GO:0006446//GO:0006118//GO:0006355//GO:0006413 pathogenesis//regulation of translational initiation//obsolete electron transport//regulation of transcription, DNA-templated//translational initiation GO:0003743//GO:0016491//GO:0009055//GO:0043565//GO:0003700 translation initiation factor activity//oxidoreductase activity//electron carrier activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005840//GO:0016020 transcription factor complex//ribosome//membrane -- -- Cluster-8309.28940 BP_3 91.91 3.86 1440 642934319 XP_008198599.1 370 1.2e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28941 BP_3 185.59 2.54 3810 270012902 EFA09350.1 371 2.4e-32 hypothetical protein TcasGA2_TC001676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28942 BP_3 70.98 1.07 3487 642934319 XP_008198599.1 370 2.8e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28944 BP_3 95.00 13.90 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28945 BP_3 64.02 2.72 1428 91089983 XP_974005.1 1138 1.0e-121 PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934014|ref|XP_008197604.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934016|ref|XP_008197605.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|270013684|gb|EFA10132.1| hypothetical protein TcasGA2_TC012312 [Tribolium castaneum] -- -- -- -- -- K15779 PGM2 phosphoglucomutase / phosphopentomutase http://www.genome.jp/dbget-bin/www_bget?ko:K15779 Q96G03 877 7.7e-93 Phosphoglucomutase-2 OS=Homo sapiens GN=PGM2 PE=1 SV=4 PF02880//PF02879//PF00408 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, C-terminal domain GO:0005975//GO:0071704 carbohydrate metabolic process//organic substance metabolic process GO:0046872//GO:0016868 metal ion binding//intramolecular transferase activity, phosphotransferases -- -- KOG1220 Phosphoglucomutase/phosphomannomutase Cluster-8309.28947 BP_3 856.16 6.91 6260 642918509 XP_008191502.1 7202 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 [Tribolium castaneum]>gi|270003219|gb|EEZ99666.1| hypothetical protein TcasGA2_TC002423 [Tribolium castaneum] 585685897 XM_006820162.1 110 2.0243e-47 PREDICTED: Saccoglossus kowalevskii brefeldin A-inhibited guanine nucleotide-exchange protein 1-like (LOC100366823), mRNA K18442 ARFGEF, BIG brefeldin A-inhibited guanine nucleotide-exchange protein http://www.genome.jp/dbget-bin/www_bget?ko:K18442 Q9Y6D5 5314 0.0e+00 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens GN=ARFGEF2 PE=1 SV=3 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity GO:0005622 intracellular KOG0929 Guanine nucleotide exchange factor Cluster-8309.28948 BP_3 286.00 13.84 1288 91078278 XP_971673.1 1321 5.5e-143 PREDICTED: probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial [Tribolium castaneum]>gi|270003914|gb|EFA00362.1| hypothetical protein TcasGA2_TC003204 [Tribolium castaneum] -- -- -- -- -- K00645 fabD http://www.genome.jp/dbget-bin/www_bget?ko:K00645 Q8T3L6 936 1.0e-99 Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Drosophila melanogaster GN=beg PE=2 SV=2 PF02617 ATP-dependent Clp protease adaptor protein ClpS GO:0030163//GO:0008152 protein catabolic process//metabolic process GO:0016740 transferase activity -- -- KOG2926 Malonyl-CoA:ACP transacylase Cluster-8309.2895 BP_3 136.00 57.74 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28950 BP_3 25.00 0.88 1656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28952 BP_3 2001.60 15.71 6434 642928921 XP_008195617.1 9069 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] 642928920 XM_008197395.1 1391 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 4872 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF01080//PF02985//PF00443//PF05395 Presenilin//HEAT repeat//Ubiquitin carboxyl-terminal hydrolase//Protein phosphatase inhibitor 1/DARPP-32 GO:0007165//GO:0016579 signal transduction//protein deubiquitination GO:0004190//GO:0004864//GO:0036459//GO:0005515 aspartic-type endopeptidase activity//protein phosphatase inhibitor activity//ubiquitinyl hydrolase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.28953 BP_3 681.73 5.24 6567 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.28954 BP_3 768.68 44.84 1118 91090252 XP_969934.1 425 3.8e-39 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 Q9CPQ3 236 1.3e-18 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=2 SV=3 PF04281 Mitochondrial import receptor subunit Tom22 GO:0006886 intracellular protein transport -- -- GO:0005741 mitochondrial outer membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.28956 BP_3 14.95 1.35 826 91087755 XP_974940.1 633 2.1e-63 PREDICTED: protein FAM50 homolog [Tribolium castaneum]>gi|270009391|gb|EFA05839.1| hypothetical protein TcasGA2_TC008623 [Tribolium castaneum] -- -- -- -- -- K13119 FAM50, XAP5 protein FAM50 http://www.genome.jp/dbget-bin/www_bget?ko:K13119 Q299F9 492 2.0e-48 Protein FAM50 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA11514 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2894 Uncharacterized conserved protein XAP-5 Cluster-8309.28959 BP_3 266.69 4.75 2997 91085405 XP_967263.1 739 4.0e-75 PREDICTED: serine/arginine-rich splicing factor 1A [Tribolium castaneum]>gi|270009156|gb|EFA05604.1| hypothetical protein TcasGA2_TC015810 [Tribolium castaneum] -- -- -- -- -- K12890 SFRS1_9 splicing factor, arginine/serine-rich 1/9 http://www.genome.jp/dbget-bin/www_bget?ko:K12890 Q5ZML3 597 4.8e-60 Serine/arginine-rich splicing factor 1 OS=Gallus gallus GN=SRSF1 PE=1 SV=3 PF00076//PF06929//PF08675//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Rotavirus VP3 protein//RNA binding domain//RNA recognition motif//RNA binding motif GO:0016032//GO:0006402//GO:0051252 viral process//mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0005525//GO:0000166//GO:0003676//GO:0004535//GO:0046872 RNA binding//GTP binding//nucleotide binding//nucleic acid binding//poly(A)-specific ribonuclease activity//metal ion binding GO:0005634//GO:0019013//GO:0005737 nucleus//viral nucleocapsid//cytoplasm KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily) Cluster-8309.28960 BP_3 1758.31 36.75 2598 91085405 XP_967263.1 788 7.1e-81 PREDICTED: serine/arginine-rich splicing factor 1A [Tribolium castaneum]>gi|270009156|gb|EFA05604.1| hypothetical protein TcasGA2_TC015810 [Tribolium castaneum] -- -- -- -- -- K12890 SFRS1_9 splicing factor, arginine/serine-rich 1/9 http://www.genome.jp/dbget-bin/www_bget?ko:K12890 Q5ZML3 634 2.1e-64 Serine/arginine-rich splicing factor 1 OS=Gallus gallus GN=SRSF1 PE=1 SV=3 PF16367//PF06929//PF00076//PF08777 RNA recognition motif//Rotavirus VP3 protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0016032 viral process GO:0005525//GO:0000166//GO:0003723//GO:0003676 GTP binding//nucleotide binding//RNA binding//nucleic acid binding GO:0019013 viral nucleocapsid KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily) Cluster-8309.28961 BP_3 17.00 1.49 840 91084049 XP_967339.1 202 2.1e-13 PREDICTED: 40S ribosomal protein S8 [Tribolium castaneum]>gi|270008005|gb|EFA04453.1| hypothetical protein TcasGA2_TC014757 [Tribolium castaneum] 70909496 AM048935.1 55 9.84806e-18 Agriotes lineatus mRNA for ribosomal protein S8e (rpS8e gene) K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 Q8WQI5 183 1.3e-12 40S ribosomal protein S8 OS=Spodoptera frugiperda GN=RpS8 PE=2 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3283 40S ribosomal protein S8 Cluster-8309.28962 BP_3 240.60 6.45 2089 270013707 EFA10155.1 2383 6.4e-266 hypothetical protein TcasGA2_TC012343 [Tribolium castaneum] -- -- -- -- -- K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 1696 1.2e-187 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 PF10662//PF00071//PF04670//PF00910//PF07231//PF03193//PF00005//PF13202//PF02367//PF00036//PF00025//PF00004//PF01926//PF07475//PF08477//PF13405//PF00735//PF07728//PF01695//PF13499 Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region//RNA helicase//Hs1pro-1 N-terminus//Protein of unknown function, DUF258//ABC transporter//EF hand//Threonylcarbamoyl adenosine biosynthesis protein TsaE//EF hand//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//HPr Serine kinase C-terminal domain//Ras of Complex, Roc, domain of DAPkinase//EF-hand domain//Septin//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//EF-hand domain pair GO:0006952//GO:0006109//GO:0000160//GO:0007264//GO:0002949//GO:0016310//GO:0006576 defense response//regulation of carbohydrate metabolic process//phosphorelay signal transduction system//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//phosphorylation//cellular biogenic amine metabolic process GO:0016887//GO:0003924//GO:0005524//GO:0000155//GO:0004672//GO:0003724//GO:0005525//GO:0005509//GO:0003723 ATPase activity//GTPase activity//ATP binding//phosphorelay sensor kinase activity//protein kinase activity//RNA helicase activity//GTP binding//calcium ion binding//RNA binding GO:0009365 protein histidine kinase complex KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.28963 BP_3 95.58 2.99 1832 270013707 EFA10155.1 376 3.0e-33 hypothetical protein TcasGA2_TC012343 [Tribolium castaneum] 642934429 XM_008199437.1 54 7.8945e-17 PREDICTED: Tribolium castaneum mitochondrial Rho GTPase (LOC657284), transcript variant X1, mRNA K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 270 2.4e-22 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.28965 BP_3 94.66 1.76 2890 642934418 XP_008197653.1 541 3.5e-52 PREDICTED: transformer-2 protein homolog beta isoform X4 [Tribolium castaneum] 642934411 XM_008199428.1 282 2.25732e-143 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X1, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 2.5e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.28966 BP_3 707.66 4.86 7314 642910921 XP_008193465.1 2693 2.5e-301 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha [Tribolium castaneum] -- -- -- -- -- K02649 PIK3R phosphoinositide-3-kinase, regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02649 Q63787 1128 3.1e-121 Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Rattus norvegicus GN=Pik3r1 PE=1 SV=1 PF07647//PF00536//PF00130//PF02198//PF02631//PF06815//PF14604//PF00620//PF00018 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Sterile alpha motif (SAM)/Pointed domain//RecX family//Reverse transcriptase connection domain//Variant SH3 domain//RhoGAP domain//SH3 domain GO:0035556//GO:0006278//GO:0007165//GO:0006282 intracellular signal transduction//RNA-dependent DNA replication//signal transduction//regulation of DNA repair GO:0043565//GO:0005515//GO:0003964 sequence-specific DNA binding//protein binding//RNA-directed DNA polymerase activity GO:0005634 nucleus KOG4637 Adaptor for phosphoinositide 3-kinase Cluster-8309.28967 BP_3 744.34 4.89 7632 642910921 XP_008193465.1 2830 0.0e+00 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha [Tribolium castaneum] -- -- -- -- -- K02649 PIK3R phosphoinositide-3-kinase, regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02649 Q63787 1128 3.2e-121 Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Rattus norvegicus GN=Pik3r1 PE=1 SV=1 PF02198//PF02631//PF00620//PF07647//PF06815//PF00130//PF00536 Sterile alpha motif (SAM)/Pointed domain//RecX family//RhoGAP domain//SAM domain (Sterile alpha motif)//Reverse transcriptase connection domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//SAM domain (Sterile alpha motif) GO:0035556//GO:0007165//GO:0006282//GO:0006278 intracellular signal transduction//signal transduction//regulation of DNA repair//RNA-dependent DNA replication GO:0043565//GO:0003964//GO:0005515 sequence-specific DNA binding//RNA-directed DNA polymerase activity//protein binding GO:0005634 nucleus KOG4637 Adaptor for phosphoinositide 3-kinase Cluster-8309.28968 BP_3 436.62 7.89 2958 478253953 ENN74245.1 1772 6.4e-195 hypothetical protein YQE_09217, partial [Dendroctonus ponderosae]>gi|546674841|gb|ERL86127.1| hypothetical protein D910_03541 [Dendroctonus ponderosae] 150013142 CP000743.1 37 3.61883e-07 Methanococcus aeolicus Nankai-3, complete genome K07767 KATNA1 katanin p60 ATPase-containing subunit A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07767 B4USW8 1439 1.1e-157 Katanin p60 ATPase-containing subunit A-like 1 OS=Otolemur garnettii GN=KATNAL1 PE=3 SV=1 PF02367//PF02562//PF00910//PF01080//PF06068//PF05496//PF07728//PF01695//PF07724//PF03286//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//RNA helicase//Presenilin//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//Pox virus Ag35 surface protein//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0002949//GO:0006281 DNA recombination//tRNA threonylcarbamoyladenosine modification//DNA repair GO:0016887//GO:0003724//GO:0009378//GO:0003723//GO:0005524//GO:0003678//GO:0004190 ATPase activity//RNA helicase activity//four-way junction helicase activity//RNA binding//ATP binding//DNA helicase activity//aspartic-type endopeptidase activity GO:0005657//GO:0009379//GO:0016021//GO:0019031 replication fork//Holliday junction helicase complex//integral component of membrane//viral envelope KOG0738 AAA+-type ATPase Cluster-8309.28969 BP_3 333.92 8.86 2109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2897 BP_3 7.00 0.48 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28970 BP_3 249.29 2.24 5662 189240823 XP_001811917.1 3289 0.0e+00 PREDICTED: ATP-dependent RNA helicase SUV3 homolog, mitochondrial [Tribolium castaneum]>gi|270013711|gb|EFA10159.1| hypothetical protein TcasGA2_TC012348 [Tribolium castaneum] 755880618 XM_005185469.2 352 0 PREDICTED: Musca domestica ATP-dependent RNA helicase SUV3 homolog, mitochondrial (LOC101900390), mRNA K17675 SUPV3L1, SUV3 ATP-dependent RNA helicase SUPV3L1/SUV3 http://www.genome.jp/dbget-bin/www_bget?ko:K17675 Q9VN03 2699 1.6e-303 ATP-dependent RNA helicase SUV3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG9791 PE=2 SV=3 PF12513//PF11965//PF00001 Mitochondrial degradasome RNA helicase subunit C terminal//Domain of unknown function (DUF3479)//7 transmembrane receptor (rhodopsin family) GO:0015994//GO:0007186 chlorophyll metabolic process//G-protein coupled receptor signaling pathway GO:0004930//GO:0004386//GO:0005524//GO:0003676//GO:0016817//GO:0016851 G-protein coupled receptor activity//helicase activity//ATP binding//nucleic acid binding//hydrolase activity, acting on acid anhydrides//magnesium chelatase activity GO:0010007//GO:0016021 magnesium chelatase complex//integral component of membrane KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily Cluster-8309.28972 BP_3 26.57 9.02 433 642930589 XP_008198247.1 314 1.1e-26 PREDICTED: threonine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum] -- -- -- -- -- K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q3ZBV8 204 2.6e-15 Threonine--tRNA ligase, cytoplasmic OS=Bos taurus GN=TARS PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.28973 BP_3 21.78 0.70 1786 642912959 XP_008201326.1 1150 5.2e-123 PREDICTED: programmed cell death 6-interacting protein [Tribolium castaneum]>gi|270001905|gb|EEZ98352.1| hypothetical protein TcasGA2_TC000807 [Tribolium castaneum] -- -- -- -- -- K12200 PDCD6IP, ALIX, RIM20 programmed cell death 6-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12200 Q9WU78 559 7.2e-56 Programmed cell death 6-interacting protein OS=Mus musculus GN=Pdcd6ip PE=1 SV=3 PF13949//PF06005//PF03462//PF14817//PF04111//PF17082//PF07926//PF10473//PF03938 ALIX V-shaped domain binding to HIV//Protein of unknown function (DUF904)//PCRF domain//HAUS augmin-like complex subunit 5//Autophagy protein Apg6//Spindle Pole Component 29//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Outer membrane protein (OmpH-like) GO:0006914//GO:0006606//GO:0006415//GO:0051225//GO:0006449//GO:0030474//GO:0000917//GO:0043093 autophagy//protein import into nucleus//translational termination//spindle assembly//regulation of translational termination//spindle pole body duplication//barrier septum assembly//FtsZ-dependent cytokinesis GO:0008134//GO:0045502//GO:0005200//GO:0051082//GO:0005515//GO:0016149//GO:0042803 transcription factor binding//dynein binding//structural constituent of cytoskeleton//unfolded protein binding//protein binding//translation release factor activity, codon specific//protein homodimerization activity GO:0005840//GO:0005823//GO:0018444//GO:0005737//GO:0070652//GO:0005856//GO:0030286//GO:0005667 ribosome//central plaque of spindle pole body//translation release factor complex//cytoplasm//HAUS complex//cytoskeleton//dynein complex//transcription factor complex KOG2220 Predicted signal transduction protein Cluster-8309.28975 BP_3 155.74 3.60 2375 546678596 ERL89178.1 1501 1.4e-163 hypothetical protein D910_06552 [Dendroctonus ponderosae] -- -- -- -- -- K14440 SMARCAL1, HARP SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14440 Q8MNV7 943 2.9e-100 Putative SMARCAL1-like protein OS=Caenorhabditis elegans GN=C16A3.1 PE=3 SV=1 PF00270//PF13949//PF01291//PF00176//PF04851 DEAD/DEAH box helicase//ALIX V-shaped domain binding to HIV//LIF / OSM family//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0007165//GO:0006955 signal transduction//immune response GO:0005515//GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0005125 protein binding//ATP binding//DNA binding//hydrolase activity//nucleic acid binding//cytokine activity GO:0005576 extracellular region KOG1000 Chromatin remodeling protein HARP/SMARCAL1, DEAD-box superfamily Cluster-8309.28977 BP_3 398.04 2.40 8286 642934565 XP_008197717.1 3886 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF01533//PF07714//PF06293//PF00069 Tospovirus nucleocapsid protein//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0016772//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//transferase activity, transferring phosphorus-containing groups//protein kinase activity GO:0016020//GO:0019013 membrane//viral nucleocapsid KOG0611 Predicted serine/threonine protein kinase Cluster-8309.2898 BP_3 353.93 10.65 1893 668457816 KFB45806.1 375 4.0e-33 AGAP006828-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- P45583 290 1.2e-24 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.28980 BP_3 146.70 0.93 7876 189241335 XP_001809545.1 1176 2.2e-125 PREDICTED: innexin inx3 [Tribolium castaneum]>gi|270013143|gb|EFA09591.1| hypothetical protein TcasGA2_TC011709 [Tribolium castaneum] 642936310 XM_001809493.2 154 8.8526e-72 PREDICTED: Tribolium castaneum innexin inx3 (LOC100141896), mRNA -- -- -- -- Q9VAS7 794 1.8e-82 Innexin inx3 OS=Drosophila melanogaster GN=Inx3 PE=1 SV=1 PF00876//PF06662//PF01292 Innexin//D-glucuronyl C5-epimerase C-terminus//Prokaryotic cytochrome b561 GO:0006118//GO:0006024 obsolete electron transport//glycosaminoglycan biosynthetic process GO:0016857//GO:0009055 racemase and epimerase activity, acting on carbohydrates and derivatives//electron carrier activity GO:0005921//GO:0016021 gap junction//integral component of membrane -- -- Cluster-8309.28982 BP_3 11.07 0.59 1193 91087501 XP_968536.1 559 1.2e-54 PREDICTED: DNA replication complex GINS protein PSF3 [Tribolium castaneum]>gi|270010665|gb|EFA07113.1| hypothetical protein TcasGA2_TC010104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDV0 242 2.8e-19 DNA replication complex GINS protein PSF3 OS=Pongo abelii GN=GINS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28983 BP_3 12.00 0.56 1330 546685745 ERL95200.1 213 1.7e-14 hypothetical protein D910_12468 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28985 BP_3 8.46 0.32 1559 91080723 XP_975387.1 284 1.2e-22 PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919596|ref|XP_008191933.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919599|ref|XP_008191934.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|270005868|gb|EFA02316.1| hypothetical protein TcasGA2_TC007982 [Tribolium castaneum] -- -- -- -- -- K16779 RAB3IP, RABIN8 Rab-3A-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K16779 Q2KJ58 164 4.0e-10 Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus GN=RAB3IL1 PE=2 SV=1 PF04627 Mitochondrial ATP synthase epsilon chain GO:0015986//GO:0015992//GO:0006119 ATP synthesis coupled proton transport//proton transport//oxidative phosphorylation GO:0046933//GO:0046961 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.28986 BP_3 28.46 0.49 3094 768410076 XP_011556278.1 421 3.1e-38 PREDICTED: uncharacterized protein LOC105387270 [Plutella xylostella] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q95SX7 267 9.1e-22 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28987 BP_3 23.04 0.39 3138 270012872 EFA09320.1 264 5.0e-20 hypothetical protein TcasGA2_TC001646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10394 Histone acetyl transferase HAT1 N-terminus GO:0016568//GO:0042967 chromatin modification//acyl-carrier-protein biosynthetic process GO:0004402 histone acetyltransferase activity GO:0000123 histone acetyltransferase complex -- -- Cluster-8309.28989 BP_3 36.97 0.38 4958 91093137 XP_969665.1 1842 8.2e-203 PREDICTED: breast cancer anti-estrogen resistance protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16832 NEDD9, HEF1, CASL enhancer of filamentation 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16832 Q61140 506 2.8e-49 Breast cancer anti-estrogen resistance protein 1 OS=Mus musculus GN=Bcar1 PE=1 SV=2 PF09726//PF01282 Transmembrane protein//Ribosomal protein S24e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0016021//GO:0005622 ribosome//integral component of membrane//intracellular -- -- Cluster-8309.28994 BP_3 1638.08 56.75 1683 478260112 ENN79897.1 1512 5.2e-165 hypothetical protein YQE_03716, partial [Dendroctonus ponderosae]>gi|546679495|gb|ERL89954.1| hypothetical protein D910_07313 [Dendroctonus ponderosae] -- -- -- -- -- K00415 QCR2, UQCRC2 ubiquinol-cytochrome c reductase core subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K00415 Q9DB77 705 8.0e-73 Cytochrome b-c1 complex subunit 2, mitochondrial OS=Mus musculus GN=Uqcrc2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2583 Ubiquinol cytochrome c reductase, subunit QCR2 Cluster-8309.28996 BP_3 23.30 0.81 1670 642914748 XP_008190336.1 1749 1.7e-192 PREDICTED: potassium channel subfamily T member 2 [Tribolium castaneum] 642914747 XM_008192114.1 474 0 PREDICTED: Tribolium castaneum potassium channel subfamily T member 2 (LOC655919), mRNA K04947 KCNT2 potassium channel subfamily T member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04947 Q6UVM4 500 4.7e-49 Potassium channel subfamily T member 2 OS=Rattus norvegicus GN=Kcnt2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3193 K+ channel subunit Cluster-8309.28998 BP_3 74.00 3.94 1196 91084843 XP_966905.1 737 2.7e-75 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 531 8.5e-53 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 PF01073//PF01118//PF01370//PF03435 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0016491//GO:0051287//GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.29002 BP_3 30.55 1.78 1121 91081971 XP_967978.1 860 1.4e-89 PREDICTED: plexin domain-containing protein 2 [Tribolium castaneum]>gi|270007319|gb|EFA03767.1| hypothetical protein TcasGA2_TC013878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DC11 499 4.1e-49 Plexin domain-containing protein 2 OS=Mus musculus GN=Plxdc2 PE=1 SV=1 PF01437 Plexin repeat -- -- -- -- GO:0016020 membrane KOG3848 Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) Cluster-8309.29003 BP_3 170.13 2.48 3597 642922441 XP_008193170.1 2357 1.1e-262 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 642922836 XM_008195125.1 329 2.10162e-169 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X1, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1929 2.0e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF00180//PF02781//PF00479 Isocitrate/isopropylmalate dehydrogenase//Glucose-6-phosphate dehydrogenase, C-terminal domain//Glucose-6-phosphate dehydrogenase, NAD binding domain GO:0006006//GO:0006749//GO:0006098//GO:0055114 glucose metabolic process//glutathione metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0016616//GO:0004345 NADP binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glucose-6-phosphate dehydrogenase activity -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.29005 BP_3 9163.07 144.89 3340 270014491 EFA10939.1 2273 5.9e-253 hypothetical protein TcasGA2_TC001770 [Tribolium castaneum] 751473836 XM_011193984.1 157 8.02224e-74 PREDICTED: Bactrocera cucurbitae endochitinase (LOC105218422), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 P36362 1808 2.0e-200 Endochitinase OS=Manduca sexta PE=2 SV=1 PF01607//PF00704//PF01757 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18//Acyltransferase family GO:0006030//GO:0005975 chitin metabolic process//carbohydrate metabolic process GO:0004553//GO:0008061//GO:0016747 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005576 extracellular region -- -- Cluster-8309.29008 BP_3 28.00 0.72 2179 546682094 ERL92080.1 359 3.3e-31 hypothetical protein D910_09402, partial [Dendroctonus ponderosae] -- -- -- -- -- K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 P48809 324 1.6e-28 Heterogeneous nuclear ribonucleoprotein 27C OS=Drosophila melanogaster GN=Hrb27C PE=1 SV=2 PF00076//PF16367//PF15150 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Phorbol-12-myristate-13-acetate-induced GO:0006919//GO:0006915//GO:0006974//GO:0001836 activation of cysteine-type endopeptidase activity involved in apoptotic process//apoptotic process//cellular response to DNA damage stimulus//release of cytochrome c from mitochondria GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.29012 BP_3 4.00 0.33 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29014 BP_3 17.91 0.45 2213 478253168 ENN73539.1 316 3.3e-26 hypothetical protein YQE_09790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q867Z4 288 2.4e-24 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01155//PF00096//PF13465//PF01428//PF16622//PF02892//PF01363 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Zinc-finger double domain//AN1-like Zinc finger//zinc-finger C2H2-type//BED zinc finger//FYVE zinc finger GO:0006464 cellular protein modification process GO:0008270//GO:0003677//GO:0016151//GO:0046872 zinc ion binding//DNA binding//nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.29015 BP_3 41.95 4.12 782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29018 BP_3 172.00 20.46 697 642927242 XP_008195193.1 154 6.3e-08 PREDICTED: uncharacterized protein LOC103313523 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29020 BP_3 95.15 1.20 4110 642912971 XP_008201333.1 1018 2.4e-107 PREDICTED: claspin homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29021 BP_3 40.85 0.55 3881 642912965 XP_008201330.1 1050 4.4e-111 PREDICTED: claspin homolog isoform X1 [Tribolium castaneum]>gi|642912967|ref|XP_008201331.1| PREDICTED: claspin homolog isoform X1 [Tribolium castaneum]>gi|642912969|ref|XP_008201332.1| PREDICTED: claspin homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29023 BP_3 648.21 8.38 4020 189236877 XP_974696.2 4794 0.0e+00 PREDICTED: exportin-5 [Tribolium castaneum] -- -- -- -- -- K14289 XPO5 exportin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K14289 Q9HAV4 1864 7.7e-207 Exportin-5 OS=Homo sapiens GN=XPO5 PE=1 SV=1 PF05236//PF03810//PF00822 Transcription initiation factor TFIID component TAF4 family//Importin-beta N-terminal domain//PMP-22/EMP/MP20/Claudin family GO:0006352//GO:0006886 DNA-templated transcription, initiation//intracellular protein transport GO:0008536 Ran GTPase binding GO:0016021//GO:0005669 integral component of membrane//transcription factor TFIID complex KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.29025 BP_3 1866.00 55.30 1918 642919394 XP_008191854.1 1370 1.7e-148 PREDICTED: apoptosis inhibitor 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35841 852 8.2e-90 Apoptosis inhibitor 5 OS=Mus musculus GN=Api5 PE=1 SV=2 PF01031//PF00714 Dynamin central region//Interferon gamma GO:0007165//GO:0006955 signal transduction//immune response GO:0005133//GO:0005525 interferon-gamma receptor binding//GTP binding GO:0005576 extracellular region KOG2213 Apoptosis inhibitor 5/fibroblast growth factor 2-interacting factor 2, and related proteins Cluster-8309.29029 BP_3 113.58 0.73 7794 642928597 XP_008199971.1 5532 0.0e+00 PREDICTED: autophagy-related protein 2 homolog A isoform X3 [Tribolium castaneum] -- -- -- -- -- K17906 ATG2 autophagy-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17906 Q80XK6 1999 3.3e-222 Autophagy-related protein 2 homolog B OS=Mus musculus GN=Atg2b PE=1 SV=3 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG2993 Cytoplasm to vacuole targeting protein Cluster-8309.2903 BP_3 69.00 28.80 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00965 Tissue inhibitor of metalloproteinase -- -- GO:0008191 metalloendopeptidase inhibitor activity -- -- -- -- Cluster-8309.29034 BP_3 2242.75 44.41 2726 91094851 XP_972051.1 2113 1.7e-234 PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating [Tribolium castaneum]>gi|270006577|gb|EFA03025.1| hypothetical protein TcasGA2_TC010448 [Tribolium castaneum] 808352053 KR024162.1 90 1.14842e-36 Drosophila melanogaster strain ZK398 ph-p-RA (ph-p) gene, partial sequence; CG3835 (CG3835) and Pgd (Pgd) genes, complete cds, alternatively spliced; bcn92-RA (bcn92) gene, complete cds; wapl (wapl) and Cyp4d1 (Cyp4d1) genes, complete cds, alternatively spliced; and CG3630-RD (CG3630) gene, partial sequence K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00033 P41570 1734 6.2e-192 6-phosphogluconate dehydrogenase, decarboxylating OS=Ceratitis capitata GN=Pgd PE=2 SV=1 PF14833//PF03446//PF00393 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//NAD binding domain of 6-phosphogluconate dehydrogenase//6-phosphogluconate dehydrogenase, C-terminal domain GO:0019521//GO:0006098//GO:0055114 D-gluconate metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0004616//GO:0051287 NADP binding//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding -- -- KOG2653 6-phosphogluconate dehydrogenase Cluster-8309.29035 BP_3 311.74 6.82 2496 91083363 XP_975142.1 1914 1.9e-211 PREDICTED: diacylglycerol O-acyltransferase 1 [Tribolium castaneum]>gi|270007773|gb|EFA04221.1| hypothetical protein TcasGA2_TC014471 [Tribolium castaneum] -- -- -- -- -- K11155 DGAT1 diacylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11155 Q9Z2A7 996 2.1e-106 Diacylglycerol O-acyltransferase 1 OS=Mus musculus GN=Dgat1 PE=1 SV=1 -- -- GO:0042967 acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG0380 Sterol O-acyltransferase/Diacylglycerol O-acyltransferase Cluster-8309.29036 BP_3 19.00 5.96 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29039 BP_3 325.25 3.85 4361 642913301 XP_008201476.1 1372 2.3e-148 PREDICTED: chymotrypsin-like elastase family member 2A isoform X2 [Tribolium castaneum]>gi|270002775|gb|EEZ99222.1| serine protease P16 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY7 451 5.9e-43 Ovochymase-1 OS=Homo sapiens GN=OVCH1 PE=2 SV=2 PF01130//PF00089 CD36 family//Trypsin GO:0006508//GO:0007155 proteolysis//cell adhesion GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.2904 BP_3 83.00 2.14 2158 478259312 ENN79214.1 1107 6.1e-118 hypothetical protein YQE_04398, partial [Dendroctonus ponderosae]>gi|546675050|gb|ERL86305.1| hypothetical protein D910_03713 [Dendroctonus ponderosae] 817186034 XM_012432081.1 87 4.2182e-35 PREDICTED: Orussus abietinus uncharacterized LOC105703587 (LOC105703587), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29040 BP_3 850.80 14.17 3186 91088135 XP_970927.1 2676 1.0e-299 PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum]>gi|642931216|ref|XP_008196487.1| PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum] -- -- -- -- -- K14015 NPLOC4, NPL4 nuclear protein localization protein 4 homolog http://www.genome.jp/dbget-bin/www_bget?ko:K14015 Q9VBP9 1976 6.3e-220 Nuclear protein localization protein 4 homolog OS=Drosophila melanogaster GN=Npl4 PE=1 SV=3 PF02565//PF15957//PF00641 Recombination protein O C terminal//Commissureless//Zn-finger in Ran binding protein and others GO:0007411//GO:0006310//GO:0006281 axon guidance//DNA recombination//DNA repair GO:0008270 zinc ion binding -- -- KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4) Cluster-8309.29041 BP_3 10.02 0.94 803 57868645 AAW57431.1 376 1.3e-33 10G08 [Ips pini] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29046 BP_3 344.45 4.14 4299 642912121 XP_008200815.1 1303 2.3e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1R3 469 4.7e-45 StAR-related lipid transfer protein 7, mitochondrial OS=Mus musculus GN=Stard7 PE=2 SV=2 PF01593//PF12831//PF07992//PF09452//PF01494//PF08264//PF01852//PF01134//PF01266//PF00965 Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//ESCRT-I subunit Mvb12//FAD binding domain//Anticodon-binding domain of tRNA//START domain//Glucose inhibited division protein A//FAD dependent oxidoreductase//Tissue inhibitor of metalloproteinase GO:0006418//GO:0055114//GO:0008033//GO:0032509 tRNA aminoacylation for protein translation//oxidation-reduction process//tRNA processing//endosome transport via multivesicular body sorting pathway GO:0000166//GO:0050660//GO:0043130//GO:0008289//GO:0008191//GO:0071949//GO:0016491 nucleotide binding//flavin adenine dinucleotide binding//ubiquitin binding//lipid binding//metalloendopeptidase inhibitor activity//FAD binding//oxidoreductase activity GO:0000813 ESCRT I complex KOG0685 Flavin-containing amine oxidase Cluster-8309.29049 BP_3 227.09 5.59 2249 91079304 XP_966317.1 1435 5.8e-156 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 648 4.4e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.2905 BP_3 5.91 0.36 1075 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29050 BP_3 409.71 10.96 2094 91079304 XP_966317.1 1435 5.4e-156 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 648 4.1e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.29052 BP_3 121.78 9.15 933 546676446 ERL87451.1 215 7.1e-15 hypothetical protein D910_04843 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29054 BP_3 2.16 3.97 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29055 BP_3 31.41 0.51 3271 642932518 XP_008197147.1 3114 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B isoform X3 [Tribolium castaneum] 642932517 XM_008198925.1 692 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03043 2566 2.5e-288 cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster GN=for PE=1 SV=3 PF07714//PF00069//PF17082 Protein tyrosine kinase//Protein kinase domain//Spindle Pole Component 29 GO:0030474//GO:0006468 spindle pole body duplication//protein phosphorylation GO:0004672//GO:0005524//GO:0005200 protein kinase activity//ATP binding//structural constituent of cytoskeleton GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG0614 cGMP-dependent protein kinase Cluster-8309.29056 BP_3 92.65 1.26 3849 642932512 XP_008197144.1 2530 1.1e-282 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum]>gi|642932514|ref|XP_008197145.1| PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum] 642932517 XM_008198925.1 605 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 P32023 2142 4.3e-239 cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 OS=Drosophila melanogaster GN=for PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.29057 BP_3 461.70 8.15 3023 478252036 ENN72467.1 917 9.1e-96 hypothetical protein YQE_10809, partial [Dendroctonus ponderosae] 586460488 XM_006860838.1 137 9.51545e-63 PREDICTED: Chrysochloris asiatica NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (NDUFS8), mRNA K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 P42028 772 2.4e-80 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Bos taurus GN=NDUFS8 PE=1 SV=1 PF08782//PF05187//PF03194 c-SKI Smad4 binding domain//Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S//LUC7 N_terminus GO:0006376//GO:0055114 mRNA splice site selection//oxidation-reduction process GO:0004174//GO:0046332//GO:0003729 electron-transferring-flavoprotein dehydrogenase activity//SMAD binding//mRNA binding GO:0005685 U1 snRNP KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit Cluster-8309.29058 BP_3 4.00 1.87 393 546682595 ERL92514.1 286 1.7e-23 hypothetical protein D910_09827 [Dendroctonus ponderosae] 318037409 NM_001201142.1 52 2.04713e-16 Ictalurus punctatus serine/threonine-protein phosphatase 2a regulatory subunit b' (ptpa), mRNA >gnl|BL_ORD_ID|9527029 Ictalurus punctatus clone CBPN47522 serine/threonine-protein phosphatase 2a regulatory subunit b' (PTPA) mRNA, complete cds K17605 PPP2R4, PTPA serine/threonine-protein phosphatase 2A activator http://www.genome.jp/dbget-bin/www_bget?ko:K17605 Q2KJ44 223 1.4e-17 Serine/threonine-protein phosphatase 2A activator OS=Bos taurus GN=PPP2R4 PE=2 SV=1 PF03095 Phosphotyrosyl phosphate activator (PTPA) protein -- -- GO:0019211 phosphatase activator activity -- -- KOG2867 Phosphotyrosyl phosphatase activator Cluster-8309.29059 BP_3 2162.10 19.38 5670 642922255 XP_008193081.1 3697 0.0e+00 PREDICTED: sodium bicarbonate cotransporter 3 isoform X2 [Tribolium castaneum] 642922254 XM_008194859.1 405 0 PREDICTED: Tribolium castaneum sodium bicarbonate cotransporter 3 (LOC661759), transcript variant X4, mRNA -- -- -- -- Q32LP4 2294 1.5e-256 Sodium-driven chloride bicarbonate exchanger OS=Bos taurus GN=SLC4A10 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.2906 BP_3 38.00 1.23 1777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29060 BP_3 23.38 0.68 1948 478262459 ENN81130.1 1047 5.0e-111 hypothetical protein YQE_02498, partial [Dendroctonus ponderosae]>gi|546672773|gb|ERL84529.1| hypothetical protein D910_01959 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T8L8 591 1.5e-59 Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Drosophila melanogaster GN=Alg10 PE=2 SV=1 PF04922 DIE2/ALG10 family GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0005789 endoplasmic reticulum membrane KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator Cluster-8309.29063 BP_3 766.31 11.47 3511 91088615 XP_974002.1 834 4.5e-86 PREDICTED: sepiapterin reductase [Tribolium castaneum]>gi|270012265|gb|EFA08713.1| hypothetical protein TcasGA2_TC006384 [Tribolium castaneum] -- -- -- -- -- K00072 SPR sepiapterin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00072 P35270 313 4.8e-27 Sepiapterin reductase OS=Homo sapiens GN=SPR PE=1 SV=1 PF00769//PF05130//PF12242//PF00106 Ezrin/radixin/moesin family//FlgN protein//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase GO:0055114//GO:0008152//GO:0044780 oxidation-reduction process//metabolic process//bacterial-type flagellum assembly GO:0016491//GO:0008092 oxidoreductase activity//cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane KOG1204 Predicted dehydrogenase Cluster-8309.29065 BP_3 132.00 1.60 4267 478253167 ENN73538.1 399 1.5e-35 hypothetical protein YQE_09789, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y2L8 139 8.7e-07 Zinc finger protein with KRAB and SCAN domains 5 OS=Homo sapiens GN=ZKSCAN5 PE=1 SV=1 PF13465//PF00096//PF05191//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Adenylate kinase, active site lid//C2H2-type zinc finger GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.29067 BP_3 1148.00 199.51 569 288558760 NP_001165744.1 289 1.1e-23 ecdysis triggering hormone preproprotein [Tribolium castaneum]>gi|270011044|gb|EFA07492.1| ecdysis triggering hormone [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29069 BP_3 26.52 0.60 2405 815806339 XP_012223941.1 320 1.2e-26 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105673125 [Linepithema humile] 642916990 XM_967678.2 157 5.75626e-74 PREDICTED: Tribolium castaneum protein translation factor SUI1 homolog (LOC661525), mRNA K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 P42678 292 8.9e-25 Protein translation factor SUI1 homolog OS=Anopheles gambiae GN=AGAP006459 PE=3 SV=1 PF01253 Translation initiation factor SUI1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.2907 BP_3 8.81 1.36 603 675376035 KFM68937.1 136 6.7e-06 hypothetical protein X975_27108, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.29070 BP_3 57.58 1.94 1720 642921367 XP_008192837.1 1077 1.5e-114 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K12375 ARSI_J arylsulfatase I/J http://www.genome.jp/dbget-bin/www_bget?ko:K12375 Q5FYB1 296 2.2e-25 Arylsulfatase I OS=Homo sapiens GN=ARSI PE=1 SV=1 PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- KOG3867 Sulfatase Cluster-8309.29074 BP_3 75.00 5.38 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29075 BP_3 456.03 20.46 1366 642921592 XP_008192437.1 1154 1.4e-123 PREDICTED: peptidyl-prolyl cis-trans isomerase D [Tribolium castaneum]>gi|270005014|gb|EFA01462.1| hypothetical protein TcasGA2_TC007008 [Tribolium castaneum] -- -- -- -- -- K05864 PPID, CYPD peptidyl-prolyl isomerase D http://www.genome.jp/dbget-bin/www_bget?ko:K05864 Q9CR16 774 6.5e-81 Peptidyl-prolyl cis-trans isomerase D OS=Mus musculus GN=Ppid PE=1 SV=3 PF13181//PF00515//PF13371//PF00160//PF13174//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Tetratricopeptide repeat//TPR repeat GO:0044267//GO:0000413//GO:0006457 cellular protein metabolic process//protein peptidyl-prolyl isomerization//protein folding GO:0005515//GO:0016853//GO:0003755 protein binding//isomerase activity//peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.29078 BP_3 44.34 6.32 630 642920229 XP_008192257.1 441 3.0e-41 PREDICTED: 60S ribosomal protein L10a isoform X1 [Tribolium castaneum] 315115352 HQ424705.1 140 4.0834e-65 Euphydryas aurinia ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 404 2.4e-38 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00468 Ribosomal protein L34 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1570 60S ribosomal protein L10A Cluster-8309.29080 BP_3 9.72 0.37 1561 91092412 XP_967539.1 1725 9.6e-190 PREDICTED: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [Tribolium castaneum]>gi|270004747|gb|EFA01195.1| hypothetical protein TcasGA2_TC010522 [Tribolium castaneum] -- -- -- -- -- K05542 DUS1 tRNA-dihydrouridine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05542 Q6P1R4 1055 1.9e-113 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens GN=DUS1L PE=1 SV=1 PF01207//PF00977//PF04309//PF03060//PF01680 Dihydrouridine synthase (Dus)//Histidine biosynthesis protein//Glycerol-3-phosphate responsive antiterminator//Nitronate monooxygenase//SOR/SNZ family GO:0006355//GO:0042823//GO:0009607//GO:0055114//GO:0006807//GO:0000105//GO:0042819//GO:0008033//GO:0002943 regulation of transcription, DNA-templated//pyridoxal phosphate biosynthetic process//response to biotic stimulus//oxidation-reduction process//nitrogen compound metabolic process//histidine biosynthetic process//vitamin B6 biosynthetic process//tRNA processing//tRNA dihydrouridine synthesis GO:0050660//GO:0018580//GO:0017150 flavin adenine dinucleotide binding//nitronate monooxygenase activity//tRNA dihydrouridine synthase activity -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.29082 BP_3 48.61 0.36 6775 189240413 XP_969795.2 2244 2.7e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.40971e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.5e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00250//PF00498 Forkhead domain//FHA domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.29083 BP_3 2215.00 29.18 3951 768431235 XP_011556884.1 5698 0.0e+00 PREDICTED: DNA-directed RNA polymerase II subunit RPB2 [Plutella xylostella] 324120671 AB597621.1 1401 0 Lucidina biplagiata RPB2 mRNA for RNA polymerase II second largest subunit, complete cds, isolate: E-19 K03010 RPB2, POLR2B DNA-directed RNA polymerase II subunit RPB2 http://www.genome.jp/dbget-bin/www_bget?ko:K03010 P30876 5320 0.0e+00 DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens GN=POLR2B PE=1 SV=1 PF04563//PF00562//PF04560//PF04566//PF04565//PF04561//PF04567 RNA polymerase beta subunit//RNA polymerase Rpb2, domain 6//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 4//RNA polymerase Rpb2, domain 3//RNA polymerase Rpb2, domain 2//RNA polymerase Rpb2, domain 5 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG0214 RNA polymerase II, second largest subunit Cluster-8309.29085 BP_3 958.04 22.51 2343 91094449 XP_966613.1 1311 1.5e-141 PREDICTED: 8-oxo-dGDP phosphatase NUDT18 [Tribolium castaneum]>gi|270000740|gb|EEZ97187.1| hypothetical protein TcasGA2_TC004374 [Tribolium castaneum] -- -- -- -- -- K17817 NUDT18, MTH3 8-oxo-dGDP phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17817 Q6ZVK8 397 5.8e-37 8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens GN=NUDT18 PE=1 SV=3 PF00293//PF13869 NUDIX domain//Nucleotide hydrolase GO:0006378 mRNA polyadenylation GO:0003729//GO:0016787 mRNA binding//hydrolase activity GO:0005849 mRNA cleavage factor complex KOG0648 Predicted NUDIX hydrolase FGF-2 and related proteins Cluster-8309.29087 BP_3 16.00 1.36 859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29089 BP_3 151.00 18.74 680 -- -- -- -- -- 642923232 XM_008195446.1 143 9.51301e-67 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2909 BP_3 223.60 8.16 1613 270003645 EFA00093.1 528 6.2e-51 hypothetical protein TcasGA2_TC002908 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80681 209 2.5e-15 Larval cuticle protein A1A OS=Tenebrio molitor PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29090 BP_3 10.80 0.44 1463 91085415 XP_967672.1 543 1.0e-52 PREDICTED: ell-associated factor Eaf [Tribolium castaneum]>gi|642926746|ref|XP_008194996.1| PREDICTED: ell-associated factor Eaf [Tribolium castaneum]>gi|270009158|gb|EFA05606.1| hypothetical protein TcasGA2_TC015812 [Tribolium castaneum] 642926744 XM_962579.2 42 2.93946e-10 PREDICTED: Tribolium castaneum ell-associated factor Eaf (LOC656023), transcript variant X1, mRNA K15186 EAF ELL-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15186 B4MR74 412 6.6e-39 Ell-associated factor Eaf OS=Drosophila willistoni GN=Eaf PE=3 SV=1 PF09726//PF07943 Transmembrane protein//Penicillin-binding protein 5, C-terminal domain GO:0006508 proteolysis GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity GO:0016021 integral component of membrane KOG4795 Protein associated with transcriptional elongation factor ELL Cluster-8309.29092 BP_3 2284.00 81.95 1635 91083571 XP_967903.1 1714 1.9e-188 PREDICTED: bystin [Tribolium castaneum]>gi|270006847|gb|EFA03295.1| hypothetical protein TcasGA2_TC013235 [Tribolium castaneum] 749731347 XM_011156599.1 191 4.8867e-93 PREDICTED: Harpegnathos saltator bystin (LOC105192443), mRNA K14797 ENP1, BYSL essential nuclear protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14797 Q5E9N0 1252 2.9e-136 Bystin OS=Bos taurus GN=BYSL PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3871 Cell adhesion complex protein bystin Cluster-8309.29093 BP_3 634.20 8.51 3884 546682290 ERL92248.1 263 8.0e-20 hypothetical protein D910_09565 [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 203 3.0e-14 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.29094 BP_3 294.15 3.97 3866 478255594 ENN75808.1 263 8.0e-20 hypothetical protein YQE_07644, partial [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 203 3.0e-14 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.29095 BP_3 20.10 0.45 2451 749749994 XP_011137233.1 350 4.1e-30 PREDICTED: ninjurin-1-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- P70617 178 1.5e-11 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF04923//PF01080//PF06424//PF02724 Ninjurin//Presenilin//PRP1 splicing factor, N-terminal//CDC45-like protein GO:0007155//GO:0000398//GO:0006270//GO:0042246 cell adhesion//mRNA splicing, via spliceosome//DNA replication initiation//tissue regeneration GO:0004190 aspartic-type endopeptidase activity GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.29096 BP_3 1.00 0.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29097 BP_3 216.07 6.19 1974 270009512 EFA05960.1 1428 3.3e-155 hypothetical protein TcasGA2_TC008778 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P20060 1177 1.7e-127 Beta-hexosaminidase subunit beta OS=Mus musculus GN=Hexb PE=2 SV=2 PF09328//PF08013//PF00728//PF08085 Domain of unknown function (DUF1984)//Tagatose 6 phosphate kinase//Glycosyl hydrolase family 20, catalytic domain//Entericidin EcnA/B family GO:0010038//GO:0009636//GO:0019402//GO:0005975//GO:0046938 response to metal ion//response to toxic substance//galactitol metabolic process//carbohydrate metabolic process//phytochelatin biosynthetic process GO:0004553//GO:0016756//GO:0046872 hydrolase activity, hydrolyzing O-glycosyl compounds//glutathione gamma-glutamylcysteinyltransferase activity//metal ion binding GO:0016020 membrane KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.29099 BP_3 110.09 0.80 6955 91089789 XP_968303.1 2953 0.0e+00 PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|642933751|ref|XP_008191514.1| PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|642933753|ref|XP_008191521.1| PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|270013600|gb|EFA10048.1| hypothetical protein TcasGA2_TC012222 [Tribolium castaneum] -- -- -- -- -- K08886 TNK2, ACK1 activated CDC42 kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08886 Q07912 1421 3.1e-155 Activated CDC42 kinase 1 OS=Homo sapiens GN=TNK2 PE=1 SV=3 PF00069//PF02535//PF00018//PF07714//PF03153//PF05365 Protein kinase domain//ZIP Zinc transporter//SH3 domain//Protein tyrosine kinase//Transcription factor IIA, alpha/beta subunit//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006367//GO:0006468//GO:0055085//GO:0030001//GO:0006122 transcription initiation from RNA polymerase II promoter//protein phosphorylation//transmembrane transport//metal ion transport//mitochondrial electron transport, ubiquinol to cytochrome c GO:0004672//GO:0046873//GO:0016301//GO:0005515//GO:0005524 protein kinase activity//metal ion transmembrane transporter activity//kinase activity//protein binding//ATP binding GO:0016020//GO:0005672//GO:0005750//GO:0005743 membrane//transcription factor TFIIA complex//mitochondrial respiratory chain complex III//mitochondrial inner membrane KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.291 BP_3 12.00 1.09 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2910 BP_3 379.01 5.21 3798 157134302 XP_001663232.1 306 8.1e-25 AAEL003112-PA [Aedes aegypti]>gi|108881397|gb|EAT45622.1| AAEL003112-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- P80681 186 2.7e-12 Larval cuticle protein A1A OS=Tenebrio molitor PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.29100 BP_3 52.16 0.57 4733 478255442 ENN75663.1 2224 4.0e-247 hypothetical protein YQE_07761, partial [Dendroctonus ponderosae] -- -- -- -- -- K08886 TNK2, ACK1 activated CDC42 kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08886 Q07912 1412 2.4e-154 Activated CDC42 kinase 1 OS=Homo sapiens GN=TNK2 PE=1 SV=3 PF05365//PF00069//PF07714//PF00018//PF14604//PF06293//PF02535//PF03153 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Protein kinase domain//Protein tyrosine kinase//SH3 domain//Variant SH3 domain//Lipopolysaccharide kinase (Kdo/WaaP) family//ZIP Zinc transporter//Transcription factor IIA, alpha/beta subunit GO:0006468//GO:0055085//GO:0006122//GO:0030001//GO:0006367 protein phosphorylation//transmembrane transport//mitochondrial electron transport, ubiquinol to cytochrome c//metal ion transport//transcription initiation from RNA polymerase II promoter GO:0005515//GO:0005524//GO:0004672//GO:0046873//GO:0016773 protein binding//ATP binding//protein kinase activity//metal ion transmembrane transporter activity//phosphotransferase activity, alcohol group as acceptor GO:0005750//GO:0005743//GO:0016020//GO:0005672 mitochondrial respiratory chain complex III//mitochondrial inner membrane//membrane//transcription factor TFIIA complex KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.29101 BP_3 189.00 10.38 1169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29106 BP_3 157.15 2.29 3603 642939073 XP_008200211.1 1985 1.6e-219 PREDICTED: DEAD-box ATP-dependent RNA helicase 20-like isoform X2 [Tribolium castaneum] 158300605 XM_320481.4 215 4.96062e-106 Anopheles gambiae str. PEST AGAP012045-PA (AgaP_AGAP012045) mRNA, complete cds K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1374 4.6e-150 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF04851//PF03328//PF00816//PF00270 Type III restriction enzyme, res subunit//HpcH/HpaI aldolase/citrate lyase family//H-NS histone family//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0016787//GO:0003677//GO:0003676//GO:0005524//GO:0003824 hydrolase activity//DNA binding//nucleic acid binding//ATP binding//catalytic activity GO:0005622 intracellular KOG0331 ATP-dependent RNA helicase Cluster-8309.29107 BP_3 13.00 1.14 841 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02148 Zn-finger in ubiquitin-hydrolases and other protein -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.29108 BP_3 3.00 0.47 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29112 BP_3 16.62 0.98 1106 478252538 ENN72954.1 1071 4.6e-114 hypothetical protein YQE_10425, partial [Dendroctonus ponderosae] 642913068 XM_008203154.1 168 1.9992e-80 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 O08648 670 6.0e-69 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.29116 BP_3 15.16 0.49 1784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29117 BP_3 108.89 1.60 3579 642930355 XP_008196362.1 1871 2.6e-206 PREDICTED: protein 4.1 homolog isoform X3 [Tribolium castaneum] 642930354 XM_008198140.1 468 0 PREDICTED: Tribolium castaneum protein 4.1 homolog (LOC662229), transcript variant X4, mRNA K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1380 9.1e-151 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29118 BP_3 37.14 0.81 2490 270009420 EFA05868.1 1871 1.8e-206 hypothetical protein TcasGA2_TC008668 [Tribolium castaneum] 642930354 XM_008198140.1 487 0 PREDICTED: Tribolium castaneum protein 4.1 homolog (LOC662229), transcript variant X4, mRNA K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1380 6.4e-151 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2912 BP_3 810.00 43.13 1197 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29120 BP_3 356.74 18.62 1215 270006529 EFA02977.1 1107 3.4e-118 hypothetical protein TcasGA2_TC030780 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64676 327 3.9e-29 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Mus musculus GN=Ugt8 PE=2 SV=2 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.29121 BP_3 18.87 0.43 2389 189236219 XP_971626.2 367 4.3e-32 PREDICTED: UDP-glucuronosyltransferase 1-3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64633 220 2.0e-16 UDP-glucuronosyltransferase 1-7 OS=Rattus norvegicus GN=Ugt1a7c PE=2 SV=1 PF15060//PF00201//PF04101//PF02531 Differentiation and proliferation regulator//UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain//PsaD GO:0015979//GO:0007275//GO:0030154//GO:0008152 photosynthesis//multicellular organismal development//cell differentiation//metabolic process GO:0016758 transferase activity, transferring hexosyl groups GO:0009522//GO:0009538 photosystem I//photosystem I reaction center -- -- Cluster-8309.29125 BP_3 2288.29 25.00 4703 189237690 XP_969477.2 3405 0.0e+00 PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|642924144|ref|XP_008194025.1| PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|270008133|gb|EFA04581.1| signal-transducer and activator of transcription protein [Tribolium castaneum] 642924143 XM_008195803.1 434 0 PREDICTED: Tribolium castaneum signal-transducer and activator of transcription protein (LOC657965), transcript variant X2, mRNA K11224 STAT5B signal transducer and activator of transcription 5B http://www.genome.jp/dbget-bin/www_bget?ko:K11224 Q9TUZ0 1741 1.7e-192 Signal transducer and activator of transcription 5B OS=Sus scrofa GN=STAT5B PE=2 SV=1 PF01017//PF02865//PF02864 STAT protein, all-alpha domain//STAT protein, protein interaction domain//STAT protein, DNA binding domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0004871//GO:0005509//GO:0003700 signal transducer activity//calcium ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.29126 BP_3 28.00 636.97 223 478251023 ENN71504.1 389 1.1e-35 hypothetical protein YQE_11797, partial [Dendroctonus ponderosae] 725566855 XM_010338088.1 145 2.17569e-68 PREDICTED: Saimiri boliviensis boliviensis tubulin beta chain-like (LOC101051381), mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 P08841 380 5.1e-36 Tubulin beta-3 chain OS=Drosophila melanogaster GN=betaTub60D PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1375 Beta tubulin Cluster-8309.29127 BP_3 140.94 4.57 1778 189237989 XP_001812744.1 753 5.6e-77 PREDICTED: ceramide-1-phosphate transfer protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DBQ8 353 5.5e-32 Ceramide-1-phosphate transfer protein OS=Danio rerio GN=cptp PE=2 SV=1 PF13603//PF08718 Leucyl-tRNA synthetase, Domain 2//Glycolipid transfer protein (GLTP) GO:0006418//GO:0046836 tRNA aminoacylation for protein translation//glycolipid transport GO:0051861//GO:0017089//GO:0002161 glycolipid binding//glycolipid transporter activity//aminoacyl-tRNA editing activity GO:0005737 cytoplasm KOG4189 Uncharacterized conserved protein Cluster-8309.29129 BP_3 4284.15 307.15 964 546684237 ERL93942.1 434 3.0e-40 hypothetical protein D910_11228 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29131 BP_3 39.84 0.63 3353 478254650 ENN74891.1 1311 2.1e-141 hypothetical protein YQE_08470, partial [Dendroctonus ponderosae] 195480065 XM_002101088.1 119 1.07173e-52 Drosophila yakuba GE15793 (Dyak\GE15793), partial mRNA -- -- -- -- -- -- -- -- PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.29135 BP_3 552.00 9.97 2959 91089793 XP_968467.1 2220 7.2e-247 PREDICTED: hexosaminidase D isoform X1 [Tribolium castaneum]>gi|270013626|gb|EFA10074.1| hypothetical protein TcasGA2_TC012248 [Tribolium castaneum] 642933757 XM_008193321.1 239 1.85155e-119 PREDICTED: Tribolium castaneum hexosaminidase D (LOC656874), transcript variant X2, mRNA K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q3U4H6 819 8.5e-86 Hexosaminidase D OS=Mus musculus GN=Hexdc PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0006355//GO:0005975 regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0004553//GO:0043169//GO:0043565//GO:0003700 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.29137 BP_3 15.61 0.55 1661 642920923 XP_008192617.1 1079 8.2e-115 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q5ZK84 582 1.4e-58 Alcohol dehydrogenase [NADP(+)] OS=Gallus gallus GN=AKR1A1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.29138 BP_3 379.00 41.68 730 91093647 XP_967704.1 765 9.3e-79 PREDICTED: protein mago nashi [Tribolium castaneum]>gi|270015823|gb|EFA12271.1| mago nashi [Tribolium castaneum] -- -- -- -- -- K12877 MAGOH protein mago nashi http://www.genome.jp/dbget-bin/www_bget?ko:K12877 P49028 716 1.8e-74 Protein mago nashi OS=Drosophila melanogaster GN=mago PE=1 SV=1 PF02792 Mago nashi protein -- -- -- -- GO:0005634 nucleus KOG3392 Exon-exon junction complex, Magoh component Cluster-8309.29139 BP_3 16.03 0.82 1235 332372492 AEE61388.1 440 7.6e-41 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PHE8 302 3.2e-26 Coiled-coil domain-containing protein 124 OS=Danio rerio GN=ccdc124 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3223 Uncharacterized conserved protein Cluster-8309.2914 BP_3 10.07 0.43 1415 189239958 XP_973407.2 1245 4.0e-134 PREDICTED: carboxypeptidase B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04069 758 4.8e-79 Carboxypeptidase B OS=Astacus astacus PE=1 SV=1 PF00246//PF04952//PF02244 Zinc carboxypeptidase//Succinylglutamate desuccinylase / Aspartoacylase family//Carboxypeptidase activation peptide GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016788//GO:0008270//GO:0004181//GO:0004180 hydrolase activity, acting on ester bonds//zinc ion binding//metallocarboxypeptidase activity//carboxypeptidase activity -- -- -- -- Cluster-8309.29141 BP_3 45.89 0.38 6151 270005549 EFA01997.1 4656 0.0e+00 hypothetical protein TcasGA2_TC007618 [Tribolium castaneum] 557024300 XM_006012274.1 56 2.07607e-17 PREDICTED: Latimeria chalumnae signal-induced proliferation-associated 1 like 1 (SIPA1L1), partial mRNA K17702 SIPA1L2, SPAL2 signal-induced proliferation-associated 1 like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17702 Q80TE4 1803 1.4e-199 Signal-induced proliferation-associated 1-like protein 2 OS=Mus musculus GN=Sipa1l2 PE=1 SV=3 PF06221//PF02145//PF04799//PF00595//PF06005 Putative zinc finger motif, C2HC5-type//Rap/ran-GAP//fzo-like conserved region//PDZ domain (Also known as DHR or GLGF)//Protein of unknown function (DUF904) GO:0008053//GO:0051056//GO:0006355//GO:0000917//GO:0043093 mitochondrial fusion//regulation of small GTPase mediated signal transduction//regulation of transcription, DNA-templated//barrier septum assembly//FtsZ-dependent cytokinesis GO:0008270//GO:0005096//GO:0003924//GO:0005515 zinc ion binding//GTPase activator activity//GTPase activity//protein binding GO:0005741//GO:0005737//GO:0005634//GO:0016021 mitochondrial outer membrane//cytoplasm//nucleus//integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.29143 BP_3 1369.48 13.87 5051 546681087 ERL91243.1 3068 0.0e+00 hypothetical protein D910_08578 [Dendroctonus ponderosae] -- -- -- -- -- K16685 WWC1 protein KIBRA http://www.genome.jp/dbget-bin/www_bget?ko:K16685 B4K6I9 1037 7.6e-111 Protein kibra OS=Drosophila mojavensis GN=Kibra PE=3 SV=1 PF05180//PF00168//PF00397//PF01253 DNL zinc finger//C2 domain//WW domain//Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0005515//GO:0003743//GO:0008270 protein binding//translation initiation factor activity//zinc ion binding GO:0005840 ribosome -- -- Cluster-8309.29144 BP_3 126.40 1.05 6076 642925611 XP_008194640.1 2652 1.2e-296 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 2.6e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29147 BP_3 10.12 1.01 776 478250454 ENN70949.1 316 1.1e-26 hypothetical protein YQE_12350, partial [Dendroctonus ponderosae]>gi|546677323|gb|ERL88180.1| hypothetical protein D910_05568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29150 BP_3 66.08 0.36 9041 642920053 XP_008192184.1 1927 2.1e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.05594e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.0e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF03396//PF02297//PF13673//PF00159//PF08159//PF03822//PF13508//PF00583//PF08445 Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Cytochrome oxidase c subunit VIb//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide//NUC153 domain//NAF domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein GO:0015992//GO:0019083//GO:0006123//GO:0007165//GO:0042967//GO:0006206//GO:0006351//GO:0006144 proton transport//viral transcription//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//acyl-carrier-protein biosynthetic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0016747//GO:0004129//GO:0003677//GO:0008080//GO:0005179 DNA-directed RNA polymerase activity//transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity//DNA binding//N-acetyltransferase activity//hormone activity GO:0005730//GO:0005739//GO:0005576//GO:0005634//GO:0045277 nucleolus//mitochondrion//extracellular region//nucleus//respiratory chain complex IV KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.29151 BP_3 254.44 1.58 8068 642920053 XP_008192184.1 2013 2.0e-222 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 2.72571e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 2.7e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF00159//PF13673//PF03396//PF02297//PF08112//PF00583//PF13508//PF13302//PF08445//PF08159//PF03822 Pancreatic hormone peptide//Acetyltransferase (GNAT) domain//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Cytochrome oxidase c subunit VIb//ATP synthase epsilon subunit//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//NUC153 domain//NAF domain GO:0015992//GO:0042967//GO:0006810//GO:0006123//GO:0007165//GO:0019083//GO:0006206//GO:0015986//GO:0006144//GO:0006351 proton transport//acyl-carrier-protein biosynthetic process//transport//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//viral transcription//pyrimidine nucleobase metabolic process//ATP synthesis coupled proton transport//purine nucleobase metabolic process//transcription, DNA-templated GO:0042626//GO:0003899//GO:0004129//GO:0016747//GO:0008080//GO:0005179//GO:0003677 ATPase activity, coupled to transmembrane movement of substances//DNA-directed RNA polymerase activity//cytochrome-c oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//hormone activity//DNA binding GO:0005730//GO:0005739//GO:0033178//GO:0005576//GO:0045277//GO:0005634 nucleolus//mitochondrion//proton-transporting two-sector ATPase complex, catalytic domain//extracellular region//respiratory chain complex IV//nucleus KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.29157 BP_3 366.64 30.88 864 332374938 AEE62610.1 1083 1.5e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03943 NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03943 Q0MQI8 808 4.7e-85 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Gorilla gorilla gorilla GN=NDUFV2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3196 NADH:ubiquinone oxidoreductase, NDUFV2/24 kD subunit Cluster-8309.2916 BP_3 374.13 20.01 1193 189239958 XP_973407.2 1376 2.2e-149 PREDICTED: carboxypeptidase B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04069 758 4.1e-79 Carboxypeptidase B OS=Astacus astacus PE=1 SV=1 PF04952//PF02244//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Carboxypeptidase activation peptide//Zinc carboxypeptidase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004180//GO:0004181//GO:0008270//GO:0016788 carboxypeptidase activity//metallocarboxypeptidase activity//zinc ion binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.29160 BP_3 1011.00 60.07 1103 91080511 XP_975872.1 992 6.7e-105 PREDICTED: V-type proton ATPase subunit D [Tribolium castaneum]>gi|270005793|gb|EFA02241.1| hypothetical protein TcasGA2_TC007903 [Tribolium castaneum] 571550213 XM_394769.5 200 3.24293e-98 PREDICTED: Apis mellifera v-type proton ATPase subunit D 1-like (LOC411295), transcript variant 1, mRNA K02149 ATPeV1D, ATP6M V-type H+-transporting ATPase subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K02149 Q9V7D2 962 8.3e-103 V-type proton ATPase subunit D 1 OS=Drosophila melanogaster GN=Vha36-1 PE=2 SV=1 PF01813//PF05261//PF00542 ATP synthase subunit D//TraM protein, DNA-binding//Ribosomal protein L7/L12 C-terminal domain GO:0006810//GO:0006412//GO:0042254//GO:0000746 transport//translation//ribosome biogenesis//conjugation GO:0003677//GO:0003735//GO:0042626 DNA binding//structural constituent of ribosome//ATPase activity, coupled to transmembrane movement of substances GO:0005840 ribosome KOG1647 Vacuolar H+-ATPase V1 sector, subunit D Cluster-8309.29161 BP_3 3505.84 76.38 2504 91092348 XP_971306.1 1591 5.3e-174 PREDICTED: uncharacterized protein LOC659947 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0061025//GO:0046813 membrane fusion//receptor-mediated virion attachment to host cell -- -- GO:0016021//GO:0019031 integral component of membrane//viral envelope -- -- Cluster-8309.29163 BP_3 140.93 3.21 2411 642937453 XP_008198842.1 569 1.6e-55 PREDICTED: protein tramtrack, beta isoform-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29165 BP_3 14.00 0.66 1316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29168 BP_3 151.00 6.83 1357 91083243 XP_973851.1 1583 2.4e-173 PREDICTED: guanine nucleotide-binding protein subunit beta-2 [Tribolium castaneum]>gi|270007716|gb|EFA04164.1| hypothetical protein TcasGA2_TC014410 [Tribolium castaneum] -- -- -- -- -- K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 P29829 1209 2.3e-131 Guanine nucleotide-binding protein subunit beta-2 OS=Drosophila melanogaster GN=Gbeta76C PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.29169 BP_3 7.00 0.97 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2917 BP_3 74.00 18.06 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29171 BP_3 128.62 1.61 4150 675381743 KFM74645.1 366 9.8e-32 Zinc finger protein 729, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A0JNB1 314 4.3e-27 Zinc finger protein 227 OS=Bos taurus GN=ZNF227 PE=2 SV=1 PF13465//PF00096//PF07975//PF13912//PF04810//PF00412//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain//C2H2-type zinc finger//Sec23/Sec24 zinc finger//LIM domain//BED zinc finger GO:0006281//GO:0006888//GO:0006886 DNA repair//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.29172 BP_3 64.77 2.39 1600 642936826 XP_008197806.1 1259 1.1e-135 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1 [Tribolium castaneum]>gi|270000937|gb|EEZ97384.1| hypothetical protein TcasGA2_TC011210 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 1045 2.9e-112 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.29173 BP_3 23.00 20.18 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29176 BP_3 1140.00 21.16 2888 -- -- -- -- -- 642937526 XM_008200861.1 124 1.5311e-55 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF09462 Mus7/MMS22 family GO:0031297//GO:0006281//GO:0006974 replication fork processing//DNA repair//cellular response to DNA damage stimulus -- -- GO:0005634 nucleus -- -- Cluster-8309.29177 BP_3 87.57 1.30 3548 642920410 XP_008192336.1 513 7.5e-49 PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum]>gi|642920412|ref|XP_008192337.1| PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum]>gi|642920414|ref|XP_008192338.1| PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29179 BP_3 133.06 2.78 2602 642917903 XP_008191376.1 1043 1.9e-110 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 270 3.4e-22 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29181 BP_3 2.00 0.64 442 795111383 XP_011882465.1 178 6.5e-11 PREDICTED: gastrula zinc finger protein xFG20-1-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7KQZ4 133 4.4e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF03470//PF07975 Zinc finger, C2H2 type//Zinc-finger double domain//XS zinc finger domain//TFIIH C1-like domain GO:0006281//GO:0031047 DNA repair//gene silencing by RNA GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.29184 BP_3 7.80 0.37 1302 642923918 XP_969405.2 342 1.9e-29 PREDICTED: serine/threonine-protein phosphatase 2A activator [Tribolium castaneum] -- -- -- -- -- K17605 PPP2R4, PTPA serine/threonine-protein phosphatase 2A activator http://www.genome.jp/dbget-bin/www_bget?ko:K17605 Q2KJ44 252 2.1e-20 Serine/threonine-protein phosphatase 2A activator OS=Bos taurus GN=PPP2R4 PE=2 SV=1 PF09572//PF03095 XamI restriction endonuclease//Phosphotyrosyl phosphate activator (PTPA) protein GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036//GO:0019211 DNA binding//Type II site-specific deoxyribonuclease activity//phosphatase activator activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG2867 Phosphotyrosyl phosphatase activator Cluster-8309.29185 BP_3 161.12 4.95 1862 478252475 ENN72897.1 849 4.3e-88 hypothetical protein YQE_10467, partial [Dendroctonus ponderosae] 318037409 NM_001201142.1 54 8.02629e-17 Ictalurus punctatus serine/threonine-protein phosphatase 2a regulatory subunit b' (ptpa), mRNA >gnl|BL_ORD_ID|9527029 Ictalurus punctatus clone CBPN47522 serine/threonine-protein phosphatase 2a regulatory subunit b' (PTPA) mRNA, complete cds K17605 PPP2R4, PTPA serine/threonine-protein phosphatase 2A activator http://www.genome.jp/dbget-bin/www_bget?ko:K17605 Q2KJ44 651 1.6e-66 Serine/threonine-protein phosphatase 2A activator OS=Bos taurus GN=PPP2R4 PE=2 SV=1 PF03095 Phosphotyrosyl phosphate activator (PTPA) protein -- -- GO:0019211 phosphatase activator activity -- -- KOG2867 Phosphotyrosyl phosphatase activator Cluster-8309.29186 BP_3 140.70 1.45 4983 688550711 XP_009299041.1 812 2.3e-83 PREDICTED: gastrula zinc finger protein XlCGF57.1-like, partial [Danio rerio] -- -- -- -- -- -- -- -- -- P52742 790 3.3e-82 Zinc finger protein 135 OS=Homo sapiens GN=ZNF135 PE=2 SV=3 PF07776//PF04931//PF06524//PF00096//PF16622//PF13912//PF12131//PF02178//PF13465 Zinc-finger associated domain (zf-AD)//DNA polymerase phi//NOA36 protein//Zinc finger, C2H2 type//zinc-finger C2H2-type//C2H2-type zinc finger//Protein of unknown function (DUF3586)//AT hook motif//Zinc-finger double domain GO:0006351//GO:0006508//GO:0006260 transcription, DNA-templated//proteolysis//DNA replication GO:0003887//GO:0003677//GO:0004197//GO:0046872//GO:0008270 DNA-directed DNA polymerase activity//DNA binding//cysteine-type endopeptidase activity//metal ion binding//zinc ion binding GO:0042575//GO:0005634 DNA polymerase complex//nucleus -- -- Cluster-8309.29187 BP_3 1097.06 21.62 2737 332375098 AEE62690.1 1294 1.6e-139 unknown [Dendroctonus ponderosae]>gi|478257120|gb|ENN77283.1| hypothetical protein YQE_06109, partial [Dendroctonus ponderosae]>gi|546683344|gb|ERL93166.1| hypothetical protein D910_10463 [Dendroctonus ponderosae] -- -- -- -- -- K08343 ATG3 ubiquitin-like-conjugating enzyme ATG3 http://www.genome.jp/dbget-bin/www_bget?ko:K08343 Q6PFS7 1020 3.9e-109 Ubiquitin-like-conjugating enzyme ATG3 OS=Danio rerio GN=atg3 PE=2 SV=1 PF06524//PF12131//PF04931 NOA36 protein//Protein of unknown function (DUF3586)//DNA polymerase phi GO:0006260//GO:0006508//GO:0006351 DNA replication//proteolysis//transcription, DNA-templated GO:0004197//GO:0008270//GO:0003887//GO:0003677 cysteine-type endopeptidase activity//zinc ion binding//DNA-directed DNA polymerase activity//DNA binding GO:0042575//GO:0005634 DNA polymerase complex//nucleus KOG2981 Protein involved in autophagocytosis during starvation Cluster-8309.29188 BP_3 83.64 3.42 1470 642916772 XP_008192547.1 685 3.5e-69 PREDICTED: peptidoglycan-recognition protein LE-like [Tribolium castaneum]>gi|270004832|gb|EFA01280.1| hypothetical protein TcasGA2_TC002790 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9VXN9 410 1.1e-38 Peptidoglycan-recognition protein LE OS=Drosophila melanogaster GN=PGRP-LE PE=1 SV=1 PF01510//PF05093 N-acetylmuramoyl-L-alanine amidase//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0009252//GO:0006807//GO:0009253//GO:0016226 peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process//iron-sulfur cluster assembly GO:0051536//GO:0008745 iron-sulfur cluster binding//N-acetylmuramoyl-L-alanine amidase activity GO:0005737 cytoplasm -- -- Cluster-8309.29190 BP_3 80.01 1.23 3425 91085889 XP_967833.1 1273 5.4e-137 PREDICTED: UPF0183 protein CG7083 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSH9 993 6.6e-106 UPF0183 protein CG7083 OS=Drosophila melanogaster GN=CG7083 PE=2 SV=1 PF05094 Late expression factor 9 (LEF-9) GO:0019083 viral transcription -- -- -- -- KOG2819 Uncharacterized conserved protein Cluster-8309.29191 BP_3 101.00 1.65 3238 642916369 XP_008190992.1 1504 8.4e-164 PREDICTED: TOM1-like protein 2 isoform X1 [Tribolium castaneum]>gi|270004201|gb|EFA00649.1| hypothetical protein TcasGA2_TC003525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRX1 828 8.4e-87 TOM1-like protein 2 OS=Mus musculus GN=Tom1l2 PE=2 SV=1 PF00790//PF03127 VHS domain//GAT domain GO:0006886 intracellular protein transport -- -- GO:0005622 intracellular KOG1087 Cytosolic sorting protein GGA2/TOM1 Cluster-8309.29194 BP_3 76.57 0.82 4769 189240067 XP_970199.2 2407 2.4e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.21611e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 4.8e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690//PF08040//PF00083//PF05480 Major Facilitator Superfamily//MNLL subunit//Sugar (and other) transporter//Staphylococcus haemolytic protein GO:0006118//GO:0009405//GO:0055085 obsolete electron transport//pathogenesis//transmembrane transport GO:0003954//GO:0022857 NADH dehydrogenase activity//transmembrane transporter activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.29196 BP_3 398.38 4.49 4564 332375078 AEE62680.1 1122 2.3e-119 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14458 MOGAT1, MGAT1 2-acylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14458 Q70VZ7 706 1.7e-72 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.29198 BP_3 30.67 0.37 4253 332375078 AEE62680.1 1234 2.2e-132 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14457 MOGAT2, MGAT2 2-acylglycerol O-acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14457 Q70VZ7 681 1.2e-69 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.29200 BP_3 24.00 0.68 1992 642923366 XP_973695.2 1701 7.4e-187 PREDICTED: uncharacterized protein LOC662511 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.29202 BP_3 102.32 3.33 1774 642920753 XP_008192548.1 1472 2.4e-160 PREDICTED: probable asparagine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270005193|gb|EFA01641.1| hypothetical protein TcasGA2_TC007211 [Tribolium castaneum] -- -- -- -- -- K01893 NARS, asnS asparaginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01893 Q96I59 1088 3.3e-117 Probable asparagine--tRNA ligase, mitochondrial OS=Homo sapiens GN=NARS2 PE=1 SV=3 PF01336//PF01409//PF00152 OB-fold nucleic acid binding domain//tRNA synthetases class II core domain (F)//tRNA synthetases class II (D, K and N) GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0003676//GO:0000166//GO:0004812//GO:0005524//GO:0000049 nucleic acid binding//nucleotide binding//aminoacyl-tRNA ligase activity//ATP binding//tRNA binding GO:0005737 cytoplasm KOG0554 Asparaginyl-tRNA synthetase (mitochondrial) Cluster-8309.29203 BP_3 105.00 3.29 1830 546684751 ERL94361.1 1480 2.9e-161 hypothetical protein D910_11641 [Dendroctonus ponderosae] 462299794 APGK01051198.1 45 7.9417e-12 Dendroctonus ponderosae Seq01051208, whole genome shotgun sequence -- -- -- -- Q7PIR5 662 8.4e-68 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083//PF05770 Major Facilitator Superfamily//Sugar (and other) transporter//Inositol 1, 3, 4-trisphosphate 5/6-kinase GO:0055085//GO:0032957 transmembrane transport//inositol trisphosphate metabolic process GO:0022857//GO:0052726//GO:0005524//GO:0047325//GO:0052725//GO:0000287 transmembrane transporter activity//inositol-1,3,4-trisphosphate 5-kinase activity//ATP binding//inositol tetrakisphosphate 1-kinase activity//inositol-1,3,4-trisphosphate 6-kinase activity//magnesium ion binding GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.29204 BP_3 13.35 0.98 946 270008326 EFA04774.1 241 7.0e-18 hypothetical protein TcasGA2_TC030735 [Tribolium castaneum] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 Q9JI18 189 3.1e-13 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.2921 BP_3 93.04 2.27 2269 270012638 EFA09086.1 284 1.7e-22 hypothetical protein TcasGA2_TC006806 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13851//PF07527//PF04362 Growth-arrest specific micro-tubule binding//Hairy Orange//Bacterial Fe(2+) trafficking GO:0006355//GO:0048870 regulation of transcription, DNA-templated//cell motility GO:0003677//GO:0005506 DNA binding//iron ion binding GO:0031514 motile cilium -- -- Cluster-8309.29210 BP_3 95.31 1.59 3183 688549951 XP_009298913.1 991 2.5e-104 PREDICTED: zinc finger protein 721-like, partial [Danio rerio] 847046770 XM_012952304.1 39 3.01294e-08 PREDICTED: Jaculus jaculus zinc finger protein 791-like (LOC101594745), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 920 1.8e-97 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF02487//PF16622//PF04810//PF13912//PF12326//PF13465//PF01586//PF11744//PF00096 CLN3 protein//zinc-finger C2H2-type//Sec23/Sec24 zinc finger//C2H2-type zinc finger//N-glycosylation protein//Zinc-finger double domain//Myogenic Basic domain//Aluminium activated malate transporter//Zinc finger, C2H2 type GO:0006355//GO:0034599//GO:0007517//GO:0015743//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//cellular response to oxidative stress//muscle organ development//malate transport//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0046872//GO:0003677 zinc ion binding//metal ion binding//DNA binding GO:0016020//GO:0030127//GO:0005634//GO:0005789 membrane//COPII vesicle coat//nucleus//endoplasmic reticulum membrane -- -- Cluster-8309.29211 BP_3 80.64 1.27 3363 91080709 XP_975318.1 1500 2.5e-163 PREDICTED: protein sly1 homolog [Tribolium castaneum]>gi|270005472|gb|EFA01920.1| hypothetical protein TcasGA2_TC007530 [Tribolium castaneum] 820837626 XM_003690680.2 92 1.09802e-37 PREDICTED: Apis florea syntaxin-5 (LOC100868396), mRNA -- -- -- -- Q24179 1253 4.6e-136 Protein sly1 homolog OS=Drosophila melanogaster GN=Slh PE=2 SV=4 PF16519//PF00804//PF00995//PF05739//PF00992 Tetramerisation domain of TRPM//Syntaxin//Sec1 family//SNARE domain//Troponin GO:0051262//GO:0006904//GO:0016192 protein tetramerization//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0005515 protein binding GO:0016020//GO:0005861 membrane//troponin complex KOG1301 Vesicle trafficking protein Sly1 (Sec1 family) Cluster-8309.29212 BP_3 51.61 0.59 4514 546681097 ERL91253.1 2467 2.5e-275 hypothetical protein D910_08588 [Dendroctonus ponderosae] 820837626 XM_003690680.2 92 1.47788e-37 PREDICTED: Apis florea syntaxin-5 (LOC100868396), mRNA -- -- -- -- Q24179 1971 3.4e-219 Protein sly1 homolog OS=Drosophila melanogaster GN=Slh PE=2 SV=4 PF00804//PF16519//PF00992//PF05739//PF08131//PF00995 Syntaxin//Tetramerisation domain of TRPM//Troponin//SNARE domain//Defensin-like peptide family//Sec1 family GO:0051262//GO:0016192//GO:0006904 protein tetramerization//vesicle-mediated transport//vesicle docking involved in exocytosis GO:0005515 protein binding GO:0016020//GO:0005576//GO:0005861 membrane//extracellular region//troponin complex KOG1301 Vesicle trafficking protein Sly1 (Sec1 family) Cluster-8309.29215 BP_3 76.00 27.74 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29216 BP_3 46.37 0.52 4596 749735954 XP_011154161.1 2960 0.0e+00 PREDICTED: armadillo segment polarity protein isoform X2 [Harpegnathos saltator] 642934622 XM_008199520.1 538 0 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X2, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 2862 0.0e+00 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 PF02985//PF07646//PF10508//PF01344//PF00514//PF01602 HEAT repeat//Kelch motif//Proteasome non-ATPase 26S subunit//Kelch motif//Armadillo/beta-catenin-like repeat//Adaptin N terminal region GO:0043248//GO:0016192//GO:0006886 proteasome assembly//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.29217 BP_3 68.47 2.65 1535 546673846 ERL85378.1 536 7.0e-52 hypothetical protein D910_02798 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09239 Topoisomerase VI B subunit, transducer GO:0006265 DNA topological change GO:0003677//GO:0003918 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity -- -- -- -- Cluster-8309.29219 BP_3 11.00 0.42 1567 255522801 NP_001157313.1 189 1.2e-11 longitudinals lacking isoform 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2BID7 132 2.1e-06 PR domain zinc finger protein 10 OS=Danio rerio GN=prdm10 PE=3 SV=2 PF05191//PF16622//PF02892//PF13912//PF05443//PF01096//PF13465//PF02148//PF00096 Adenylate kinase, active site lid//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//ROS/MUCR transcriptional regulator protein//Transcription factor S-II (TFIIS)//Zinc-finger double domain//Zn-finger in ubiquitin-hydrolases and other protein//Zinc finger, C2H2 type GO:0006355//GO:0006351//GO:0006144//GO:0046034 regulation of transcription, DNA-templated//transcription, DNA-templated//purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0003676//GO:0004017//GO:0046872//GO:0003677 zinc ion binding//nucleic acid binding//adenylate kinase activity//metal ion binding//DNA binding -- -- -- -- Cluster-8309.29220 BP_3 24.98 0.40 3268 642932613 XP_968153.2 4055 0.0e+00 PREDICTED: uncharacterized protein LOC656535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.29222 BP_3 525.00 6.73 4053 642915933 XP_008190817.1 1231 4.8e-132 PREDICTED: ras-related protein Rap-2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96D21 358 3.3e-32 GTP-binding protein Rhes OS=Homo sapiens GN=RASD2 PE=1 SV=1 PF00071//PF00025//PF04670//PF00503//PF01926//PF03193//PF08477 Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0019001//GO:0004871//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0395 Ras-related GTPase Cluster-8309.29223 BP_3 280.86 2.72 5273 91078468 XP_967964.1 2089 2.0e-231 PREDICTED: integral membrane protein GPR180 isoform X1 [Tribolium castaneum]>gi|270003859|gb|EFA00307.1| hypothetical protein TcasGA2_TC003142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q976I0 277 1.1e-22 Peptidyl-tRNA hydrolase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=pth PE=3 SV=1 PF10192//PF01981//PF02891//PF05051 Rhodopsin-like GPCR transmembrane domain//Peptidyl-tRNA hydrolase PTH2//MIZ/SP-RING zinc finger//Cytochrome C oxidase copper chaperone (COX17) GO:0006825//GO:0007186//GO:0019236 copper ion transport//G-protein coupled receptor signaling pathway//response to pheromone GO:0016531//GO:0005507//GO:0004045//GO:0008270 copper chaperone activity//copper ion binding//aminoacyl-tRNA hydrolase activity//zinc ion binding GO:0005758 mitochondrial intermembrane space KOG3282 Uncharacterized conserved protein Cluster-8309.29227 BP_3 178.57 3.07 3097 270009865 EFA06313.1 1914 2.3e-211 hypothetical protein TcasGA2_TC009182 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REG1 740 1.3e-76 Squamous cell carcinoma antigen recognized by T-cells 3 OS=Pongo abelii GN=SART3 PE=2 SV=1 PF12052//PF05843//PF00076//PF16367//PF13174//PF08777 Voltage gated calcium channel subunit beta domain 4Aa N terminal//Suppressor of forked protein (Suf)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Tetratricopeptide repeat//RNA binding motif GO:0006397//GO:0006816//GO:0070588 mRNA processing//calcium ion transport//calcium ion transmembrane transport GO:0003723//GO:0005515//GO:0003676//GO:0005245 RNA binding//protein binding//nucleic acid binding//voltage-gated calcium channel activity GO:0005634//GO:0005891 nucleus//voltage-gated calcium channel complex KOG0128 RNA-binding protein SART3 (RRM superfamily) Cluster-8309.29229 BP_3 101.00 6.39 1053 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29233 BP_3 31.25 0.53 3127 546685504 ERL95002.1 830 1.2e-85 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29235 BP_3 72.68 0.80 4663 642935249 XP_008197930.1 1729 9.8e-190 PREDICTED: cdk10/11-like protein isoform X1 [Tribolium castaneum] 808133727 XM_012313986.1 209 1.39288e-102 PREDICTED: Bombus terrestris cyclin-dependent kinase 11B (LOC100650971), transcript variant X6, mRNA K08818 CDC2L cell division cycle 2-like http://www.genome.jp/dbget-bin/www_bget?ko:K08818 Q9VPC0 1397 1.3e-152 Serine/threonine-protein kinase PITSLRE OS=Drosophila melanogaster GN=Pitslre PE=1 SV=1 PF05324//PF00069//PF01166//PF04987//PF07714 Sperm antigen HE2//Protein kinase domain//TSC-22/dip/bun family//Phosphatidylinositolglycan class N (PIG-N)//Protein tyrosine kinase GO:0006355//GO:0006506//GO:0006468 regulation of transcription, DNA-templated//GPI anchor biosynthetic process//protein phosphorylation GO:0003700//GO:0004672//GO:0005524//GO:0016740 transcription factor activity, sequence-specific DNA binding//protein kinase activity//ATP binding//transferase activity GO:0005576//GO:0005667//GO:0005789 extracellular region//transcription factor complex//endoplasmic reticulum membrane -- -- Cluster-8309.29236 BP_3 18.53 0.45 2274 642935249 XP_008197930.1 1176 6.4e-126 PREDICTED: cdk10/11-like protein isoform X1 [Tribolium castaneum] 808133727 XM_012313986.1 202 5.24909e-99 PREDICTED: Bombus terrestris cyclin-dependent kinase 11B (LOC100650971), transcript variant X6, mRNA K08818 CDC2L cell division cycle 2-like http://www.genome.jp/dbget-bin/www_bget?ko:K08818 Q9VPC0 1032 1.3e-110 Serine/threonine-protein kinase PITSLRE OS=Drosophila melanogaster GN=Pitslre PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.2924 BP_3 6.00 0.66 727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29240 BP_3 22.33 0.44 2734 478256154 ENN76352.1 1753 9.5e-193 hypothetical protein YQE_07129, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BTK5 172 8.3e-11 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF13181//PF00515//PF13414//PF00856 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.29241 BP_3 1278.75 9.65 6677 642910859 XP_008193438.1 1525 6.4e-166 PREDICTED: mitogen-activated protein kinase 14B-like [Tribolium castaneum] 749732005 XM_011139608.1 229 1.52303e-113 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1333 4.8e-145 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF06293//PF00069//PF02434//PF01762//PF07714//PF13414 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Fringe-like//Galactosyltransferase//Protein tyrosine kinase//TPR repeat GO:0006486//GO:0006468 protein glycosylation//protein phosphorylation GO:0016773//GO:0008378//GO:0004672//GO:0005524//GO:0016757//GO:0005515 phosphotransferase activity, alcohol group as acceptor//galactosyltransferase activity//protein kinase activity//ATP binding//transferase activity, transferring glycosyl groups//protein binding GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.29242 BP_3 279.95 1.83 7662 642911971 XP_008199044.1 6534 0.0e+00 PREDICTED: endoribonuclease Dcr-1 [Tribolium castaneum]>gi|642911973|ref|XP_008199045.1| PREDICTED: endoribonuclease Dcr-1 [Tribolium castaneum] 755864608 XM_005179866.2 182 2.34388e-87 PREDICTED: Musca domestica endoribonuclease Dcr-1 (LOC101896691), mRNA K11592 DICER1, DCR1 endoribonuclease Dicer http://www.genome.jp/dbget-bin/www_bget?ko:K11592 Q9VCU9 1952 9.2e-217 Endoribonuclease Dcr-1 OS=Drosophila melanogaster GN=Dcr-1 PE=1 SV=1 PF00636//PF02723//PF03368//PF02170//PF14622 Ribonuclease III domain//Non-structural protein NS3/Small envelope protein E//Dicer dimerisation domain//PAZ domain//Ribonuclease-III-like GO:0051252//GO:0006396 regulation of RNA metabolic process//RNA processing GO:0005515//GO:0016891//GO:0003723//GO:0004525 protein binding//endoribonuclease activity, producing 5'-phosphomonoesters//RNA binding//ribonuclease III activity GO:0016020 membrane KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.29243 BP_3 2087.40 31.50 3486 91088287 XP_968620.1 2906 0.0e+00 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [Tribolium castaneum]>gi|270012778|gb|EFA09226.1| hypothetical protein TcasGA2_TC006271 [Tribolium castaneum] 830244945 XM_012734906.1 514 0 PREDICTED: Condylura cristata succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), mRNA K00234 SDHA, SDH1 succinate dehydrogenase (ubiquinone) flavoprotein subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00234 Q9YHT1 2618 2.5e-294 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Gallus gallus GN=SDHA PE=1 SV=2 PF01494//PF02910//PF07992//PF01266//PF01134 FAD binding domain//Fumarate reductase flavoprotein C-term//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Glucose inhibited division protein A GO:0008033//GO:0055114//GO:0022900//GO:0006099 tRNA processing//oxidation-reduction process//electron transport chain//tricarboxylic acid cycle GO:0016491//GO:0071949//GO:0016627//GO:0050660 oxidoreductase activity//FAD binding//oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding -- -- KOG2403 Succinate dehydrogenase, flavoprotein subunit Cluster-8309.29244 BP_3 446.78 4.55 5023 642938700 XP_008196774.1 1653 6.9e-181 PREDICTED: PWWP domain-containing protein 2A-like isoform X1 [Tribolium castaneum]>gi|270015802|gb|EFA12250.1| hypothetical protein TcasGA2_TC016110 [Tribolium castaneum] -- -- -- -- -- K10732 GINS1, PSF1 GINS complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10732 Q14691 515 2.6e-50 DNA replication complex GINS protein PSF1 OS=Homo sapiens GN=GINS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3303 Predicted alpha-helical protein, potentially involved in replication/repair Cluster-8309.29245 BP_3 194.20 2.94 3472 478252986 ENN73368.1 2585 4.0e-289 hypothetical protein YQE_10018, partial [Dendroctonus ponderosae] 847107195 XM_012958238.1 37 4.25541e-07 PREDICTED: Xenopus (Silurana) tropicalis piwi-like RNA-mediated gene silencing 4 (piwil4), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 Q7PLK0 1621 1.0e-178 Protein argonaute-3 OS=Drosophila melanogaster GN=AGO3 PE=1 SV=3 PF02171//PF02170 Piwi domain//PAZ domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.29246 BP_3 490.88 5.93 4280 642911817 XP_008200757.1 2677 1.1e-299 PREDICTED: histone-arginine methyltransferase CARMER isoform X1 [Tribolium castaneum]>gi|270014548|gb|EFA10996.1| hypothetical protein TcasGA2_TC004581 [Tribolium castaneum] -- -- -- -- -- K05931 CARM1, PRMT4 histone-arginine methyltransferase CARM1 http://www.genome.jp/dbget-bin/www_bget?ko:K05931 Q174R2 1725 1.1e-190 Histone-arginine methyltransferase CARMER OS=Aedes aegypti GN=CARM1 PE=3 SV=1 PF08241//PF05175//PF03602//PF05185 Methyltransferase domain//Methyltransferase small domain//Conserved hypothetical protein 95//PRMT5 arginine-N-methyltransferase GO:0008152//GO:0006479//GO:0031167 metabolic process//protein methylation//rRNA methylation GO:0008168 methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.29248 BP_3 138.56 1.05 6661 478256920 ENN77089.1 1979 1.4e-218 hypothetical protein YQE_06424, partial [Dendroctonus ponderosae] -- -- -- -- -- K09257 NFKBIL2 NF-kappa-B inhibitor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09257 Q9VSA4 748 3.3e-77 Tonsoku-like protein OS=Drosophila melanogaster GN=CG7457 PE=1 SV=1 PF13174//PF13181//PF13606//PF13176//PF13414//PF00515//PF13374//PF02827//PF00023 Tetratricopeptide repeat//Tetratricopeptide repeat//Ankyrin repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Ankyrin repeat GO:0045859//GO:0006469 regulation of protein kinase activity//negative regulation of protein kinase activity GO:0005515//GO:0004862 protein binding//cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex KOG4177 Ankyrin Cluster-8309.29249 BP_3 32.39 0.32 5217 642935257 XP_008197935.1 1801 4.9e-198 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q6NRG5 1144 3.1e-123 NADPH-dependent diflavin oxidoreductase 1 OS=Xenopus laevis GN=ndor1 PE=2 SV=1 PF01771//PF07646//PF00258//PF00667//PF00175//PF12641//PF01344 Herpesvirus alkaline exonuclease//Kelch motif//Flavodoxin//FAD binding domain//Oxidoreductase NAD-binding domain//Flavodoxin domain//Kelch motif GO:0055114 oxidation-reduction process GO:0003677//GO:0004527//GO:0010181//GO:0016491//GO:0005515 DNA binding//exonuclease activity//FMN binding//oxidoreductase activity//protein binding -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.29250 BP_3 40.69 1.70 1445 189233571 XP_967872.2 638 9.8e-64 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96B67 176 1.5e-11 Arrestin domain-containing protein 3 OS=Homo sapiens GN=ARRDC3 PE=1 SV=1 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0051287 NAD binding -- -- -- -- Cluster-8309.29253 BP_3 9.00 0.52 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29254 BP_3 82.16 1.04 4095 642913301 XP_008201476.1 1372 2.2e-148 PREDICTED: chymotrypsin-like elastase family member 2A isoform X2 [Tribolium castaneum]>gi|270002775|gb|EEZ99222.1| serine protease P16 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O18824 474 1.2e-45 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130//PF00089 CD36 family//Trypsin GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.29256 BP_3 149.00 10.86 953 91092096 XP_971769.1 652 1.5e-65 PREDICTED: ribosomal RNA-processing protein 7 homolog A [Tribolium castaneum]>gi|270004673|gb|EFA01121.1| hypothetical protein TcasGA2_TC010334 [Tribolium castaneum] -- -- -- -- -- K14545 RRP7 ribosomal RNA-processing protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14545 Q5RA17 435 9.2e-42 Ribosomal RNA-processing protein 7 homolog A OS=Pongo abelii GN=RRP7A PE=2 SV=1 PF00076//PF04928 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Poly(A) polymerase central domain GO:0043631 RNA polyadenylation GO:0004652//GO:0003676 polynucleotide adenylyltransferase activity//nucleic acid binding -- -- KOG4008 rRNA processing protein RRP7 Cluster-8309.29257 BP_3 526.14 16.77 1804 478257213 ENN77376.1 2060 1.6e-228 hypothetical protein YQE_06201, partial [Dendroctonus ponderosae] -- -- -- -- -- K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q6TGS6 1969 2.3e-219 Tyrosine--tRNA ligase, cytoplasmic OS=Danio rerio GN=yars PE=2 SV=2 PF01588//PF00579//PF08039 Putative tRNA binding domain//tRNA synthetases class I (W and Y)//Mitochondrial proteolipid GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0000049//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//tRNA binding//nucleotide binding//ATP binding GO:0005739 mitochondrion KOG2144 Tyrosyl-tRNA synthetase, cytoplasmic Cluster-8309.29259 BP_3 289.13 4.33 3510 642915779 XP_008200075.1 2249 3.7e-250 PREDICTED: uncharacterized protein LOC103314829 [Tribolium castaneum]>gi|270003127|gb|EEZ99574.1| hypothetical protein TcasGA2_TC001560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02525 135 2.1e-06 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00096//PF13912//PF07776 Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.29261 BP_3 2.00 0.70 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02477 Nucleocapsid N protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.29262 BP_3 85.00 7.35 849 91087541 XP_970326.1 181 5.7e-11 PREDICTED: V-type proton ATPase subunit G [Tribolium castaneum]>gi|270009446|gb|EFA05894.1| hypothetical protein TcasGA2_TC008706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XZH6 132 1.1e-06 V-type proton ATPase subunit G OS=Drosophila melanogaster GN=Vha13 PE=3 SV=1 PF03938//PF04111//PF01086//PF03040//PF01442//PF00833 Outer membrane protein (OmpH-like)//Autophagy protein Apg6//Clathrin light chain//CemA family//Apolipoprotein A1/A4/E domain//Ribosomal S17 GO:0042157//GO:0006869//GO:0006412//GO:0042254//GO:0006914//GO:0016192//GO:0006886 lipoprotein metabolic process//lipid transport//translation//ribosome biogenesis//autophagy//vesicle-mediated transport//intracellular protein transport GO:0008289//GO:0003735//GO:0051082//GO:0005198 lipid binding//structural constituent of ribosome//unfolded protein binding//structural molecule activity GO:0005576//GO:0005840//GO:0005622//GO:0030130//GO:0016021//GO:0030132 extracellular region//ribosome//intracellular//clathrin coat of trans-Golgi network vesicle//integral component of membrane//clathrin coat of coated pit -- -- Cluster-8309.29263 BP_3 15.07 2.55 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03396 Poxvirus DNA-directed RNA polymerase, 35 kD subunit GO:0019083//GO:0006206//GO:0006351//GO:0006144 viral transcription//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.29264 BP_3 4.38 0.59 650 478250527 ENN71022.1 140 2.5e-06 hypothetical protein YQE_12421, partial [Dendroctonus ponderosae]>gi|546678988|gb|ERL89521.1| hypothetical protein D910_06887 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03396 Poxvirus DNA-directed RNA polymerase, 35 kD subunit GO:0006144//GO:0006351//GO:0019083//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//viral transcription//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.29265 BP_3 1031.20 14.77 3657 189234163 XP_967233.2 958 1.9e-100 PREDICTED: receptor expression-enhancing protein 4-like [Tribolium castaneum] 482684005 XM_001361907.3 101 1.18662e-42 Drosophila pseudoobscura pseudoobscura GA30269, transcript variant B (Dpse\GA30269), mRNA K17338 REEP1_2_3_4 receptor expression-enhancing protein 1/2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17338 Q8VCD6 543 1.1e-53 Receptor expression-enhancing protein 2 OS=Mus musculus GN=Reep2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.29266 BP_3 106.75 21.14 535 91089079 XP_971357.1 280 1.2e-22 PREDICTED: DNA-directed RNA polymerase III subunit RPC9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VHM6 126 3.5e-06 DNA-directed RNA polymerase III subunit RPC9 OS=Rattus norvegicus GN=Crcp PE=2 SV=1 PF03874 RNA polymerase Rpb4 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.29267 BP_3 1.00 0.51 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29268 BP_3 129.13 3.75 1953 642925360 XP_008194517.1 1929 2.6e-213 PREDICTED: adiponectin receptor protein isoform X1 [Tribolium castaneum]>gi|642925362|ref|XP_008194518.1| PREDICTED: adiponectin receptor protein isoform X1 [Tribolium castaneum]>gi|270008824|gb|EFA05272.1| hypothetical protein TcasGA2_TC015429 [Tribolium castaneum] 332372817 BT126587.1 431 0 Dendroctonus ponderosae clone DPO1421_D03 unknown mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 1453 1.7e-159 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF00060//PF03006 Ligand-gated ion channel//Haemolysin-III related GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.29269 BP_3 412.87 12.59 1872 546680534 ERL90794.1 1833 3.4e-202 hypothetical protein D910_08140 [Dendroctonus ponderosae] 332372817 BT126587.1 453 0 Dendroctonus ponderosae clone DPO1421_D03 unknown mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 1470 1.7e-161 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF00060//PF03006 Ligand-gated ion channel//Haemolysin-III related GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.29270 BP_3 8.68 0.40 1331 478259433 ENN79323.1 390 5.2e-35 hypothetical protein YQE_04232, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N2E2 151 1.1e-08 von Willebrand factor D and EGF domain-containing protein OS=Homo sapiens GN=VWDE PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29271 BP_3 212.31 2.12 5114 91084209 XP_968139.1 2200 2.6e-244 PREDICTED: uncharacterized protein LOC656520 [Tribolium castaneum]>gi|642925194|ref|XP_008194464.1| PREDICTED: uncharacterized protein LOC656520 [Tribolium castaneum]>gi|270008783|gb|EFA05231.1| hypothetical protein TcasGA2_TC015377 [Tribolium castaneum] -- -- -- -- -- K04458 PTPRR receptor-type tyrosine-protein phosphatase R http://www.genome.jp/dbget-bin/www_bget?ko:K04458 P54829 272 3.9e-22 Tyrosine-protein phosphatase non-receptor type 5 OS=Homo sapiens GN=PTPN5 PE=1 SV=4 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.29272 BP_3 142.00 4.55 1796 642940140 XP_008192185.1 221 2.8e-15 PREDICTED: uncharacterized protein LOC103312673 [Tribolium castaneum]>gi|270017232|gb|EFA13678.1| hypothetical protein TcasGA2_TC001394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29273 BP_3 70.61 0.68 5312 270012222 EFA08670.1 2246 1.3e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06974//PF03007 Protein of unknown function (DUF1298)//Wax ester synthase-like Acyl-CoA acyltransferase domain GO:0046486//GO:0042967//GO:0045017 glycerolipid metabolic process//acyl-carrier-protein biosynthetic process//glycerolipid biosynthetic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.29274 BP_3 1471.73 9.57 7701 642923476 XP_008193526.1 2358 1.9e-262 PREDICTED: nuclear pore complex protein Nup214 [Tribolium castaneum] -- -- -- -- -- K14863 YTM1, WDR12 ribosome biogenesis protein YTM1 http://www.genome.jp/dbget-bin/www_bget?ko:K14863 Q17BB0 1090 8.3e-117 Ribosome biogenesis protein WDR12 homolog OS=Aedes aegypti GN=AAEL005041 PE=3 SV=1 PF00400//PF08024 WD domain, G-beta repeat//Ant antimicrobial peptide GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515 protein binding GO:0005576 extracellular region KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats) Cluster-8309.29280 BP_3 1.27 0.46 424 659495114 AID66668.1 354 2.5e-31 short-chain specific acyl-CoA dehydrogenase [Agrotis segetum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q07417 290 2.7e-25 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acads PE=1 SV=2 PF00441 Acyl-CoA dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.29281 BP_3 34.91 0.54 3386 546685504 ERL95002.1 827 2.8e-85 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29282 BP_3 189.97 1.60 6017 642936806 XP_008199624.1 5536 0.0e+00 PREDICTED: protein sickie isoform X2 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 6.7e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF00910//PF08702//PF07926//PF10473//PF06160//PF00004//PF13851//PF01832//PF16716//PF07728//PF01695//PF04111//PF16326 RNA helicase//Fibrinogen alpha/beta chain family//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//Bone marrow stromal antigen 2//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Autophagy protein Apg6//ABC transporter C-terminal domain GO:0018874//GO:0006560//GO:0048870//GO:0000921//GO:0051607//GO:0030168//GO:0007165//GO:0006525//GO:0006914//GO:0051258//GO:0006558//GO:0006568//GO:0006606//GO:0042207 benzoate metabolic process//proline metabolic process//cell motility//septin ring assembly//defense response to virus//platelet activation//signal transduction//arginine metabolic process//autophagy//protein polymerization//L-phenylalanine metabolic process//tryptophan metabolic process//protein import into nucleus//styrene catabolic process GO:0003677//GO:0003723//GO:0004040//GO:0030674//GO:0042803//GO:0003724//GO:0005524//GO:0045502//GO:0008134//GO:0005102//GO:0016887 DNA binding//RNA binding//amidase activity//protein binding, bridging//protein homodimerization activity//RNA helicase activity//ATP binding//dynein binding//transcription factor binding//receptor binding//ATPase activity GO:0030286//GO:0005667//GO:0031514//GO:0016021//GO:0005940//GO:0005577 dynein complex//transcription factor complex//motile cilium//integral component of membrane//septin ring//fibrinogen complex -- -- Cluster-8309.29283 BP_3 365.45 2.83 6515 642936804 XP_008199623.1 6018 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 7.3e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF00307//PF00910//PF08702//PF07926//PF10473//PF06160//PF13851//PF00004//PF16716//PF01832//PF07728//PF01695//PF04111 Calponin homology (CH) domain//RNA helicase//Fibrinogen alpha/beta chain family//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Growth-arrest specific micro-tubule binding//ATPase family associated with various cellular activities (AAA)//Bone marrow stromal antigen 2//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Autophagy protein Apg6 GO:0006525//GO:0007165//GO:0051258//GO:0006914//GO:0006606//GO:0006568//GO:0006558//GO:0042207//GO:0018874//GO:0051607//GO:0000921//GO:0048870//GO:0006560//GO:0030168 arginine metabolic process//signal transduction//protein polymerization//autophagy//protein import into nucleus//tryptophan metabolic process//L-phenylalanine metabolic process//styrene catabolic process//benzoate metabolic process//defense response to virus//septin ring assembly//cell motility//proline metabolic process//platelet activation GO:0005524//GO:0008134//GO:0045502//GO:0016887//GO:0005102//GO:0003723//GO:0004040//GO:0005515//GO:0030674//GO:0042803//GO:0003724 ATP binding//transcription factor binding//dynein binding//ATPase activity//receptor binding//RNA binding//amidase activity//protein binding//protein binding, bridging//protein homodimerization activity//RNA helicase activity GO:0016021//GO:0031514//GO:0005940//GO:0005577//GO:0030286//GO:0005667 integral component of membrane//motile cilium//septin ring//fibrinogen complex//dynein complex//transcription factor complex -- -- Cluster-8309.29285 BP_3 19.35 1.38 970 546681721 ERL91758.1 188 1.0e-11 hypothetical protein D910_09084, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29286 BP_3 354.00 16.00 1358 91078340 XP_973522.1 1336 1.1e-144 PREDICTED: palmitoyltransferase ZDHHC3 [Tribolium castaneum]>gi|270003971|gb|EFA00419.1| hypothetical protein TcasGA2_TC003270 [Tribolium castaneum] 808125672 XM_012310529.1 179 1.8933e-86 PREDICTED: Bombus terrestris palmitoyltransferase ZDHHC3 (LOC100642519), mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9NYG2 863 3.1e-91 Palmitoyltransferase ZDHHC3 OS=Homo sapiens GN=ZDHHC3 PE=1 SV=2 PF01529//PF03600 DHHC palmitoyltransferase//Citrate transporter GO:0055085 transmembrane transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0016021 integral component of membrane KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.29288 BP_3 263.42 3.22 4240 357625687 EHJ76049.1 1321 1.8e-142 dimethyladenosine transferase [Danaus plexippus] 505801989 XM_004608470.1 131 2.89894e-59 PREDICTED: Sorex araneus DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) (DIMT1), mRNA K14191 DIM1 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14191 Q9VAQ5 1179 2.2e-127 Probable dimethyladenosine transferase OS=Drosophila melanogaster GN=CG11837 PE=2 SV=1 PF05958//PF09445//PF08123//PF02390//PF08241//PF01135//PF05175//PF05401//PF01209 tRNA (Uracil-5-)-methyltransferase//RNA cap guanine-N2 methyltransferase//Histone methylation protein DOT1//Putative methyltransferase//Methyltransferase domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Nodulation protein S (NodS)//ubiE/COQ5 methyltransferase family GO:0006396//GO:0008033//GO:0006554//GO:0006464//GO:0009312//GO:0009877//GO:0006479//GO:0009451//GO:0006400//GO:0046500//GO:0008152//GO:0009452//GO:0001510 RNA processing//tRNA processing//lysine catabolic process//cellular protein modification process//oligosaccharide biosynthetic process//nodulation//protein methylation//RNA modification//tRNA modification//S-adenosylmethionine metabolic process//metabolic process//7-methylguanosine RNA capping//RNA methylation GO:0008168//GO:0008176//GO:0004719//GO:0018024//GO:0008757//GO:0008173 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//histone-lysine N-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//RNA methyltransferase activity -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.29289 BP_3 12.00 27.35 291 226968624 YP_002808573.1 474 2.1e-45 cytochrome b [Scylla paramamosain]>gi|225697860|gb|ACO07227.1| cytochrome b [Scylla paramamosain]>gi|403311099|gb|AFR34058.1| cytochrome b (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 291 2.02812e-149 Scylla paramamosain mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 Q9MDZ9 396 9.4e-38 Cytochrome b OS=Drosophila simulans GN=mt:Cyt-b PE=3 SV=1 -- -- GO:0022904//GO:0006118 respiratory electron transport chain//obsolete electron transport GO:0016491//GO:0046872//GO:0009055 oxidoreductase activity//metal ion binding//electron carrier activity GO:0016021//GO:0070469//GO:0005739 integral component of membrane//respiratory chain//mitochondrion KOG4663 Cytochrome b Cluster-8309.2929 BP_3 128.07 2.75 2534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29290 BP_3 672.84 9.25 3797 646712353 KDR17135.1 1800 4.7e-198 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [Zootermopsis nevadensis] 755992161 XM_011314822.1 149 2.55702e-69 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 1401 3.6e-153 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00549 CoA-ligase GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.29291 BP_3 15.22 0.54 1647 642918534 XP_008191512.1 363 8.6e-32 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 82 1.92765e-32 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- O01761 139 3.4e-07 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF02570 Immunoglobulin domain//Precorrin-8X methylmutase GO:0009236//GO:0015994 cobalamin biosynthetic process//chlorophyll metabolic process GO:0005515//GO:0016993 protein binding//precorrin-8X methylmutase activity -- -- -- -- Cluster-8309.29293 BP_3 510.00 7.94 3388 642910465 XP_008200225.1 441 1.6e-40 PREDICTED: uncharacterized protein LOC103314871 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03810 Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0008536 Ran GTPase binding -- -- -- -- Cluster-8309.29295 BP_3 214.43 3.86 2969 270014518 EFA10966.1 358 5.9e-31 hypothetical protein TcasGA2_TC004128 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.29296 BP_3 31.14 0.90 1955 642930026 XP_008196217.1 1535 1.3e-167 PREDICTED: homothorax isoform X1 [Tribolium castaneum] 675893071 XM_009033790.1 110 6.24956e-48 Helobdella robusta hypothetical protein mRNA K15613 MEIS1 homeobox protein Meis1 http://www.genome.jp/dbget-bin/www_bget?ko:K15613 O46339 1130 4.9e-122 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.29297 BP_3 1350.04 23.29 3086 478257505 ENN77661.1 3915 0.0e+00 hypothetical protein YQE_05955, partial [Dendroctonus ponderosae] 195398740 XM_002057943.1 488 0 Drosophila virilis GJ15746 (Dvir\GJ15746), mRNA K12392 AP1B1 AP-1 complex subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12392 Q10567 2480 2.2e-278 AP-1 complex subunit beta-1 OS=Homo sapiens GN=AP1B1 PE=1 SV=2 PF02883//PF09066//PF02985//PF00514//PF08802//PF03094//PF01602 Adaptin C-terminal domain//Beta2-adaptin appendage, C-terminal sub-domain//HEAT repeat//Armadillo/beta-catenin-like repeat//Cytochrome B6-F complex Fe-S subunit//Mlo family//Adaptin N terminal region GO:0006118//GO:0055114//GO:0016192//GO:0006886//GO:0006952 obsolete electron transport//oxidation-reduction process//vesicle-mediated transport//intracellular protein transport//defense response GO:0009496//GO:0051537//GO:0005515 plastoquinol--plastocyanin reductase activity//2 iron, 2 sulfur cluster binding//protein binding GO:0030117//GO:0009512//GO:0016021//GO:0042651//GO:0030131 membrane coat//cytochrome b6f complex//integral component of membrane//thylakoid membrane//clathrin adaptor complex KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit Cluster-8309.29301 BP_3 40.42 2.38 1110 546680487 ERL90753.1 191 5.1e-12 hypothetical protein D910_08100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29302 BP_3 259.80 10.16 1524 478259251 ENN79153.1 428 2.3e-39 hypothetical protein YQE_04339, partial [Dendroctonus ponderosae]>gi|546678413|gb|ERL89036.1| hypothetical protein D910_06414 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4MPK3 202 1.5e-14 Protein kintoun OS=Drosophila willistoni GN=Ppi20 PE=3 SV=1 PF03286 Pox virus Ag35 surface protein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.29303 BP_3 32.76 0.65 2726 270000737 EEZ97184.1 1575 4.1e-172 hypothetical protein TcasGA2_TC004371 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14AW5 222 1.3e-16 Putative methyltransferase NSUN7 OS=Mus musculus GN=Nsun7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29304 BP_3 27.68 3.92 632 642919827 XP_001814264.2 241 4.6e-18 PREDICTED: vascular endothelial growth factor A-A-like [Tribolium castaneum]>gi|270005397|gb|EFA01845.1| hypothetical protein TcasGA2_TC007448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-8309.29305 BP_3 375.10 9.98 2103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895 Signal transducing histidine kinase, homodimeric domain GO:0006935//GO:0000160//GO:0016310 chemotaxis//phosphorelay signal transduction system//phosphorylation GO:0004673//GO:0000155 protein histidine kinase activity//phosphorelay sensor kinase activity GO:0009365//GO:0005737 protein histidine kinase complex//cytoplasm -- -- Cluster-8309.29307 BP_3 322.02 3.30 4991 642937100 XP_008198691.1 1294 2.9e-139 PREDICTED: uncharacterized protein LOC659764 [Tribolium castaneum] -- -- -- -- -- K16315 GSG2 serine/threonine-protein kinase haspin http://www.genome.jp/dbget-bin/www_bget?ko:K16315 P83103 759 1.3e-78 Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster GN=Haspin PE=2 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG2464 Serine/threonine kinase (haspin family) Cluster-8309.2931 BP_3 8.00 0.46 1137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29316 BP_3 506.23 26.89 1199 91082061 XP_972013.1 763 2.6e-78 PREDICTED: nucleoporin NUP53 [Tribolium castaneum]>gi|270007411|gb|EFA03859.1| hypothetical protein TcasGA2_TC013975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFH5 259 3.0e-21 Nucleoporin NUP53 OS=Homo sapiens GN=NUP35 PE=1 SV=1 PF02458 Transferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG4285 Mitotic phosphoprotein Cluster-8309.29317 BP_3 29.00 6.71 500 -- -- -- -- -- 380041533 JQ407437.1 281 1.32972e-143 Austinograea rodriguezensis 28S large subunit ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29318 BP_3 206.00 34.08 583 270010451 EFA06899.1 789 1.2e-81 hypothetical protein TcasGA2_TC009846 [Tribolium castaneum] 801393574 XM_012202706.1 111 4.97004e-49 PREDICTED: Atta cephalotes 5'-3' exoribonuclease 2 homolog (LOC105621236), mRNA K12619 XRN2, RAT1 5'-3' exoribonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12619 Q9DBR1 671 2.4e-69 5'-3' exoribonuclease 2 OS=Mus musculus GN=Xrn2 PE=1 SV=1 PF03615//PF03159 GCM motif protein//XRN 5'-3' exonuclease N-terminus GO:0006355 regulation of transcription, DNA-templated GO:0004527//GO:0003676//GO:0003677 exonuclease activity//nucleic acid binding//DNA binding -- -- KOG2044 5'-3' exonuclease HKE1/RAT1 Cluster-8309.29319 BP_3 16.00 1.93 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2932 BP_3 29.11 2.88 779 642924223 XP_008194205.1 487 1.7e-46 PREDICTED: endocuticle structural glycoprotein SgAbd-8-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 289 6.4e-25 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- -- -- Cluster-8309.29320 BP_3 98.57 0.70 7059 642939955 XP_008200728.1 3180 0.0e+00 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 484 1.4e-46 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF02214//PF00617//PF04900 BTB/POZ domain//RasGEF domain//Fcf1 GO:0043087//GO:0007264//GO:0051260 regulation of GTPase activity//small GTPase mediated signal transduction//protein homooligomerization GO:0005085 guanyl-nucleotide exchange factor activity GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.29321 BP_3 234.91 1.56 7566 642939957 XP_008200788.1 3180 0.0e+00 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939959|ref|XP_008200850.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939961|ref|XP_008200899.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939963|ref|XP_008200939.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939965|ref|XP_008200984.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939967|ref|XP_008201036.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 484 1.5e-46 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF04900//PF00617//PF00536//PF02214//PF07647 Fcf1//RasGEF domain//SAM domain (Sterile alpha motif)//BTB/POZ domain//SAM domain (Sterile alpha motif) GO:0043087//GO:0007264//GO:0051260 regulation of GTPase activity//small GTPase mediated signal transduction//protein homooligomerization GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.29324 BP_3 62.83 0.42 7562 642939957 XP_008200788.1 2230 1.3e-247 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939959|ref|XP_008200850.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939961|ref|XP_008200899.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939963|ref|XP_008200939.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939965|ref|XP_008200984.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939967|ref|XP_008201036.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 484 1.5e-46 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF02214//PF00536//PF07647//PF04900//PF00617 BTB/POZ domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Fcf1//RasGEF domain GO:0043087//GO:0007264//GO:0051260 regulation of GTPase activity//small GTPase mediated signal transduction//protein homooligomerization GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.29325 BP_3 268.86 1.79 7537 642939957 XP_008200788.1 3180 0.0e+00 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939959|ref|XP_008200850.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939961|ref|XP_008200899.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939963|ref|XP_008200939.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939965|ref|XP_008200984.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939967|ref|XP_008201036.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 484 1.5e-46 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF07647//PF00536//PF02214//PF00617//PF04900 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//BTB/POZ domain//RasGEF domain//Fcf1 GO:0043087//GO:0007264//GO:0051260 regulation of GTPase activity//small GTPase mediated signal transduction//protein homooligomerization GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.29326 BP_3 136.41 8.52 1063 642936884 XP_969823.3 473 9.8e-45 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 214 4.4e-16 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29327 BP_3 23.84 1.08 1359 270001017 EEZ97464.1 324 2.4e-27 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 258 4.4e-21 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF02137//PF07964 Adenosine-deaminase (editase) domain//Rec10 / Red1 GO:0006144//GO:0051598//GO:0007131//GO:0006807//GO:0006396 purine nucleobase metabolic process//meiotic recombination checkpoint//reciprocal meiotic recombination//nitrogen compound metabolic process//RNA processing GO:0003723//GO:0005198//GO:0004000 RNA binding//structural molecule activity//adenosine deaminase activity -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.29329 BP_3 42.12 0.84 2716 642923611 XP_972526.2 825 3.8e-85 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X1 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.16046e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 625 2.4e-63 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.2933 BP_3 74.03 0.45 8256 242005002 XP_002423364.1 1571 3.6e-171 hormone receptor hr3, putative [Pediculus humanus corporis]>gi|212506394|gb|EEB10626.1| hormone receptor hr3, putative [Pediculus humanus corporis] 642929407 XM_008197603.1 379 0 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X3, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P49868 753 1.1e-77 Probable nuclear hormone receptor HR3 OS=Galleria mellonella GN=HR3 PE=2 SV=1 PF00105//PF00104//PF07998 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor//Peptidase family M54 GO:0009987//GO:0006355//GO:0043401 cellular process//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0005488//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4216 Steroid hormone nuclear receptor Cluster-8309.29330 BP_3 308.00 12.26 1503 642922640 XP_008193258.1 720 3.2e-73 PREDICTED: probable RNA polymerase II nuclear localization protein SLC7A6OS isoform X2 [Tribolium castaneum]>gi|270007526|gb|EFA03974.1| hypothetical protein TcasGA2_TC014121 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2BDB7 163 5.0e-10 Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Xenopus laevis GN=slc7a6os PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29332 BP_3 61.11 0.61 5112 642938910 XP_008195559.1 1869 6.3e-206 PREDICTED: DENN domain-containing protein 1B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 912 2.4e-96 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.29333 BP_3 38.98 0.45 4486 642917522 XP_008191238.1 157 1.8e-07 PREDICTED: fragile X mental retardation syndrome-related protein 1 isoform X5 [Tribolium castaneum] 642917523 XM_008193017.1 66 4.17097e-23 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29334 BP_3 50.12 2.65 1204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29335 BP_3 27.57 0.40 3621 478251486 ENN71949.1 495 9.4e-47 hypothetical protein YQE_11383, partial [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q08DK4 299 2.1e-25 Mitochondrial glutamate carrier 1 OS=Bos taurus GN=SLC25A22 PE=2 SV=1 PF00519 Papillomavirus helicase GO:0006260 DNA replication GO:0004003//GO:0003677//GO:0005524 ATP-dependent DNA helicase activity//DNA binding//ATP binding GO:0005657 replication fork KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.29338 BP_3 1006.00 48.48 1292 -- -- -- -- -- 462473955 APGK01001494.1 40 3.3471e-09 Dendroctonus ponderosae Seq01001494, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2934 BP_3 634.12 3.88 8177 242005002 XP_002423364.1 1702 2.3e-186 hormone receptor hr3, putative [Pediculus humanus corporis]>gi|212506394|gb|EEB10626.1| hormone receptor hr3, putative [Pediculus humanus corporis] 642929407 XM_008197603.1 666 0 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X3, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P49868 753 1.1e-77 Probable nuclear hormone receptor HR3 OS=Galleria mellonella GN=HR3 PE=2 SV=1 PF00105//PF07998//PF00104 Zinc finger, C4 type (two domains)//Peptidase family M54//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401//GO:0009987 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//cellular process GO:0008270//GO:0005488//GO:0043565//GO:0003700 zinc ion binding//binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.29342 BP_3 1.00 3.70 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29347 BP_3 49.79 0.44 5772 270008949 EFA05397.1 1318 5.5e-142 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 704 3.6e-72 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF13855//PF06385 Leucine rich repeat//Baculovirus LEF-11 protein GO:0019058//GO:0006355 viral life cycle//regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-8309.29349 BP_3 56.42 1.12 2714 270008949 EFA05397.1 1205 3.3e-129 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 630 6.4e-64 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.2935 BP_3 7796.95 49.45 7892 189239421 XP_974561.2 2215 7.3e-246 PREDICTED: probable nuclear hormone receptor HR3 isoform X1 [Tribolium castaneum] 642929404 XM_969468.3 895 0 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X1, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P31396 1437 5.0e-157 Probable nuclear hormone receptor HR3 OS=Drosophila melanogaster GN=Hr46 PE=2 SV=1 PF00104//PF07998//PF00105 Ligand-binding domain of nuclear hormone receptor//Peptidase family M54//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.29352 BP_3 223.15 5.73 2168 646682520 KDR02319.1 1568 2.1e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.51483e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.0e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF00937//PF07714//PF00069 Coronavirus nucleocapsid protein//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.29353 BP_3 84.22 0.84 5142 642930106 XP_008196254.1 1585 5.4e-173 PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum]>gi|642930108|ref|XP_008196255.1| PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q5R7H0 1066 3.4e-114 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Pongo abelii GN=DHTKD1 PE=2 SV=1 PF00676//PF09412 Dehydrogenase E1 component//Endoribonuclease XendoU GO:0008152 metabolic process GO:0016624//GO:0016788 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//hydrolase activity, acting on ester bonds -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.29354 BP_3 78.29 0.50 7780 270009468 EFA05916.1 2024 1.0e-223 hypothetical protein TcasGA2_TC008732 [Tribolium castaneum] 686207191 AP014521.1 40 2.06049e-08 Candidatus Tachikawaea gelatinosa DNA, complete genome K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q96HY7 1540 5.6e-169 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Homo sapiens GN=DHTKD1 PE=1 SV=2 PF00676//PF09412 Dehydrogenase E1 component//Endoribonuclease XendoU GO:0008152 metabolic process GO:0016788//GO:0016624 hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.29356 BP_3 10.41 0.31 1906 478250163 ENN70666.1 732 1.6e-74 hypothetical protein YQE_12611, partial [Dendroctonus ponderosae] -- -- -- -- -- K14648 ENDOU, PP11 poly(U)-specific endoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K14648 Q9VZ49 504 1.8e-49 Poly(U)-specific endoribonuclease homolog OS=Drosophila melanogaster GN=CG2145 PE=1 SV=1 PF09412 Endoribonuclease XendoU -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2849 Placental protein 11 Cluster-8309.29357 BP_3 13.49 0.57 1441 332376793 AEE63536.1 639 7.5e-64 unknown [Dendroctonus ponderosae] -- -- -- -- -- K09569 FKBP2 FK506-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09569 Q54SR7 402 9.4e-38 FK506-binding protein 2 OS=Dictyostelium discoideum GN=fkbp2 PE=3 SV=1 PF00254//PF13202//PF13405//PF13833//PF00036//PF13499 FKBP-type peptidyl-prolyl cis-trans isomerase//EF hand//EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair GO:0006457 protein folding GO:0005509 calcium ion binding -- -- KOG0549 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.29358 BP_3 19.85 0.34 3133 157125087 XP_001660614.1 880 1.8e-91 AAEL010071-PA [Aedes aegypti]>gi|108873773|gb|EAT37998.1| AAEL010071-PA [Aedes aegypti] -- -- -- -- -- K00797 speE, SRM spermidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00797 Q64674 778 5.1e-81 Spermidine synthase OS=Mus musculus GN=Srm PE=2 SV=1 -- -- GO:0008152 metabolic process GO:0016740 transferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.29360 BP_3 15.00 0.45 1910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29366 BP_3 26.13 1.20 1339 852805968 XP_012891429.1 277 6.6e-22 PREDICTED: zinc finger protein 33B-like [Dipodomys ordii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q32M78 277 2.7e-23 Zinc finger protein 699 OS=Homo sapiens GN=ZNF699 PE=1 SV=1 PF05443//PF13465//PF00096//PF02146//PF16622//PF13912 ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//Zinc finger, C2H2 type//Sir2 family//zinc-finger C2H2-type//C2H2-type zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0070403//GO:0003677//GO:0008270 metal ion binding//NAD+ binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.29368 BP_3 230.00 2.18 5381 642929988 XP_008196055.1 1781 1.1e-195 PREDICTED: patj homolog [Tribolium castaneum] -- -- -- -- -- K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 Q9NB04 727 7.2e-75 Patj homolog OS=Drosophila melanogaster GN=Patj PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.29370 BP_3 25.31 0.54 2565 642917183 XP_008191154.1 360 3.0e-31 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05140 133 2.6e-06 Clathrin coat assembly protein AP180 OS=Rattus norvegicus GN=Snap91 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29371 BP_3 32.00 2.28 968 478256533 ENN76717.1 813 3.4e-84 hypothetical protein YQE_06782, partial [Dendroctonus ponderosae]>gi|546679994|gb|ERL90356.1| hypothetical protein D910_07705 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q14588 289 8.0e-25 Zinc finger protein 234 OS=Homo sapiens GN=ZNF234 PE=2 SV=3 PF06467//PF03067//PF00830//PF00096//PF05180//PF13912//PF02892//PF04810//PF00301//PF13465 MYM-type Zinc finger with FCS sequence motif//Chitin binding domain//Ribosomal L28 family//Zinc finger, C2H2 type//DNL zinc finger//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger//Rubredoxin//Zinc-finger double domain GO:0042254//GO:0006888//GO:0006886 ribosome biogenesis//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0005506//GO:0003735//GO:0008270//GO:0003677 metal ion binding//iron ion binding//structural constituent of ribosome//zinc ion binding//DNA binding GO:0005840//GO:0019028//GO:0030127 ribosome//viral capsid//COPII vesicle coat -- -- Cluster-8309.29372 BP_3 726.45 39.11 1187 91076410 XP_969526.1 1356 4.5e-147 PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002563|gb|EEZ99010.1| hypothetical protein TcasGA2_TC004878 [Tribolium castaneum] 731510745 XM_010600440.1 62 1.8074e-21 PREDICTED: Loxodonta africana aldose reductase-related protein 2-like (LOC100673621), mRNA K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15122 972 6.2e-104 Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.29373 BP_3 17.56 0.72 1473 270011235 EFA07683.1 313 4.9e-26 hypothetical protein TcasGA2_TC030729 [Tribolium castaneum] -- -- -- -- -- K13114 PNN pinin http://www.genome.jp/dbget-bin/www_bget?ko:K13114 P79149 146 4.6e-08 Pinin OS=Canis familiaris GN=PNN PE=2 SV=3 PF00787//PF15225 PX domain//Interleukin 32 GO:0006955 immune response GO:0035091 phosphatidylinositol binding -- -- -- -- Cluster-8309.29383 BP_3 76.00 1.21 3315 546672912 ERL84628.1 663 2.8e-66 hypothetical protein D910_02056 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35416 300 1.4e-25 Paramyosin, short form OS=Drosophila melanogaster GN=Prm PE=2 SV=2 PF15745//PF12678 AP-1 complex-associated regulatory protein//RING-H2 zinc finger GO:1900025//GO:2000146//GO:0048203//GO:0034315 negative regulation of substrate adhesion-dependent cell spreading//negative regulation of cell motility//vesicle targeting, trans-Golgi to endosome//regulation of Arp2/3 complex-mediated actin nucleation GO:0008270//GO:0035650 zinc ion binding//AP-1 adaptor complex binding -- -- -- -- Cluster-8309.29384 BP_3 27.40 0.54 2745 91087957 XP_972849.1 2550 3.6e-285 PREDICTED: eukaryotic translation initiation factor 3 subunit B [Tribolium castaneum]>gi|270011918|gb|EFA08366.1| hypothetical protein TcasGA2_TC006009 [Tribolium castaneum] 759033163 XM_011349720.1 153 1.10066e-71 PREDICTED: Cerapachys biroi eukaryotic translation initiation factor 3 subunit B (LOC105285460), mRNA K03253 EIF3B translation initiation factor 3 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K03253 Q1HDZ5 2003 4.0e-223 Eukaryotic translation initiation factor 3 subunit B OS=Bombyx mori GN=eIF3-S9 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0000166//GO:0003676//GO:0003743 nucleotide binding//nucleic acid binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG2314 Translation initiation factor 3, subunit b (eIF-3b) Cluster-8309.29386 BP_3 1000.27 15.99 3307 91087179 XP_975411.1 869 3.7e-90 PREDICTED: flavin reductase (NADPH) [Tribolium castaneum]>gi|270010563|gb|EFA07011.1| hypothetical protein TcasGA2_TC009981 [Tribolium castaneum] -- -- -- -- -- K05901 BLVRB biliverdin reductase / flavin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K05901 P30043 441 6.5e-42 Flavin reductase (NADPH) OS=Homo sapiens GN=BLVRB PE=1 SV=3 PF13508//PF00583//PF13302//PF13673//PF01370 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//NAD dependent epimerase/dehydratase family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0000166//GO:0003824//GO:0050662 N-acetyltransferase activity//nucleotide binding//catalytic activity//coenzyme binding -- -- KOG3397 Acetyltransferases Cluster-8309.29388 BP_3 123.82 1.31 4845 91090806 XP_970749.1 4647 0.0e+00 PREDICTED: ubiquitin-protein ligase E3B [Tribolium castaneum]>gi|270013259|gb|EFA09707.1| hypothetical protein TcasGA2_TC011840 [Tribolium castaneum] 573905099 XM_006640208.1 158 3.24648e-74 PREDICTED: Lepisosteus oculatus ubiquitin-protein ligase E3B-like (LOC102687052), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q08CZ0 2767 1.9e-311 Ubiquitin-protein ligase E3B OS=Xenopus tropicalis GN=ube3b PE=2 SV=1 PF00632//PF00612 HECT-domain (ubiquitin-transferase)//IQ calmodulin-binding motif GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.29389 BP_3 76.54 0.81 4846 91090806 XP_970749.1 3178 0.0e+00 PREDICTED: ubiquitin-protein ligase E3B [Tribolium castaneum]>gi|270013259|gb|EFA09707.1| hypothetical protein TcasGA2_TC011840 [Tribolium castaneum] 642935863 XM_965656.2 317 1.33012e-162 PREDICTED: Tribolium castaneum ubiquitin-protein ligase E3B (LOC659339), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q08CZ0 1607 5.9e-177 Ubiquitin-protein ligase E3B OS=Xenopus tropicalis GN=ube3b PE=2 SV=1 PF00632//PF00612 HECT-domain (ubiquitin-transferase)//IQ calmodulin-binding motif GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.2939 BP_3 16868.09 400.45 2322 91078176 XP_967241.1 2499 2.5e-279 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 1807 1.8e-200 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- GO:0006979//GO:0006804//GO:0055114 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004601//GO:0020037 peroxidase activity//heme binding -- -- -- -- Cluster-8309.29390 BP_3 67.44 1.44 2548 91091700 XP_972740.1 2485 1.2e-277 PREDICTED: mannosyl-oligosaccharide glucosidase [Tribolium castaneum]>gi|270001063|gb|EEZ97510.1| hypothetical protein TcasGA2_TC011354 [Tribolium castaneum] -- -- -- -- -- K01228 GCS1 mannosyl-oligosaccharide glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01228 F4HTM3 1377 1.4e-150 Mannosyl-oligosaccharide glucosidase GCS1 OS=Arabidopsis thaliana GN=GCS1 PE=1 SV=1 -- -- GO:0009311 oligosaccharide metabolic process GO:0004573 mannosyl-oligosaccharide glucosidase activity -- -- KOG2161 Glucosidase I Cluster-8309.29393 BP_3 149.44 5.96 1501 642917757 XP_008191356.1 636 1.7e-63 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 92 4.83979e-38 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.29394 BP_3 1382.00 62.88 1351 642934996 XP_008199899.1 498 1.6e-47 PREDICTED: pre-mRNA-splicing ATP-dependent RNA helicase PRP28-like [Tribolium castaneum]>gi|642934998|ref|XP_008199900.1| PREDICTED: pre-mRNA-splicing ATP-dependent RNA helicase PRP28-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29395 BP_3 682.00 61.87 823 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2940 BP_3 36.91 1.67 1358 91078176 XP_967241.1 1045 5.9e-111 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 645 5.9e-66 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29401 BP_3 3023.05 28.18 5463 189242442 XP_001807060.1 1958 3.2e-216 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- K19599 DOME cytokine receptor domeless http://www.genome.jp/dbget-bin/www_bget?ko:K19599 Q9VWE0 500 1.5e-48 Cytokine receptor OS=Drosophila melanogaster GN=dome PE=1 SV=1 PF00041//PF16794 Fibronectin type III domain//Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29402 BP_3 565.27 193.34 432 91094205 XP_971661.1 161 6.0e-09 PREDICTED: cytochrome c oxidase subunit 7A1, mitochondrial [Tribolium castaneum]>gi|270011120|gb|EFA07568.1| hypothetical protein TcasGA2_TC015888 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VHS2 122 8.2e-06 Probable cytochrome c oxidase subunit 7A, mitochondrial OS=Drosophila melanogaster GN=CG9603 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29404 BP_3 226.00 12.75 1146 91080179 XP_970720.1 1130 6.9e-121 PREDICTED: inhibitor of growth protein 1 [Tribolium castaneum]>gi|270005646|gb|EFA02094.1| hypothetical protein TcasGA2_TC007731 [Tribolium castaneum] -- -- -- -- -- K19197 ING1 inhibitor of growth protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19197 Q9QXV3 463 6.3e-45 Inhibitor of growth protein 1 OS=Mus musculus GN=Ing1 PE=2 SV=1 PF00628 PHD-finger -- -- GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.29405 BP_3 14.00 5.94 404 170321839 BAG14264.1 314 1.0e-26 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P28175 142 3.7e-08 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.29406 BP_3 18.00 2.27 674 642912272 XP_008200632.1 230 9.3e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 124 7.5e-06 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29407 BP_3 1.00 7.27 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29408 BP_3 898.68 24.73 2043 332376384 AEE63332.1 290 3.1e-23 unknown [Dendroctonus ponderosae]>gi|478255402|gb|ENN75624.1| hypothetical protein YQE_07802, partial [Dendroctonus ponderosae]>gi|546675094|gb|ERL86344.1| hypothetical protein D910_03752 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00307//PF05497 Calponin homology (CH) domain//Destabilase GO:0005975 carbohydrate metabolic process GO:0005515//GO:0003796 protein binding//lysozyme activity -- -- -- -- Cluster-8309.2941 BP_3 1383.00 73.64 1197 268607726 NP_001161320.1 467 5.5e-44 cuticle protein precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 129 3.5e-06 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.29410 BP_3 18.78 0.42 2453 91090594 XP_972814.1 1985 1.1e-219 PREDICTED: ATP-binding cassette sub-family F member 3 [Tribolium castaneum]>gi|270013337|gb|EFA09785.1| hypothetical protein TcasGA2_TC011927 [Tribolium castaneum] 755851249 XM_005175430.2 126 1.00381e-56 PREDICTED: Musca domestica ATP-binding cassette sub-family F member 3 (LOC101901338), mRNA K06158 ABCF3 ATP-binding cassette, subfamily F, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06158 Q8K268 1603 8.7e-177 ATP-binding cassette sub-family F member 3 OS=Mus musculus GN=Abcf3 PE=1 SV=1 PF01926//PF13304//PF08477//PF02465//PF02367//PF03266//PF00005//PF00485 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase//Flagellar hook-associated protein 2 N-terminus//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NTPase//ABC transporter//Phosphoribulokinase / Uridine kinase family GO:0007264//GO:0002949//GO:0006200//GO:0008152 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//obsolete ATP catabolic process//metabolic process GO:0005525//GO:0016887//GO:0016301//GO:0005524//GO:0098519 GTP binding//ATPase activity//kinase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides GO:0009424 bacterial-type flagellum hook KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b Cluster-8309.29412 BP_3 307.00 13.55 1384 91081317 XP_969842.1 1282 2.0e-138 PREDICTED: KRR1 small subunit processome component homolog [Tribolium castaneum] 769851452 XM_011638863.1 153 5.48266e-72 PREDICTED: Pogonomyrmex barbatus KRR1 small subunit processome component homolog (LOC105427209), mRNA K06961 KRR1 ribosomal RNA assembly protein http://www.genome.jp/dbget-bin/www_bget?ko:K06961 B4N0P7 1070 3.1e-115 KRR1 small subunit processome component homolog OS=Drosophila willistoni GN=dbe PE=3 SV=1 PF13014//PF00013 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2874 rRNA processing protein Cluster-8309.29413 BP_3 1196.28 13.26 4640 573884393 XP_006630279.1 261 1.6e-19 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 729-like [Lepisosteus oculatus] 642937236 XM_008200529.1 145 5.23786e-67 PREDICTED: Tribolium castaneum zinc finger protein 1 (LOC100141776), transcript variant X4, mRNA K09299 ZEB1_2 zinc finger homeobox protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K09299 Q03936 256 2.6e-20 Zinc finger protein 92 OS=Homo sapiens GN=ZNF92 PE=2 SV=2 PF00046//PF00096//PF13465//PF01155//PF05920//PF13912 Homeobox domain//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Homeobox KN domain//C2H2-type zinc finger GO:0006355//GO:0006464 regulation of transcription, DNA-templated//cellular protein modification process GO:0003677//GO:0046872//GO:0016151 DNA binding//metal ion binding//nickel cation binding -- -- -- -- Cluster-8309.29416 BP_3 21.15 0.58 2059 546678918 ERL89456.1 328 1.2e-27 hypothetical protein D910_06823 [Dendroctonus ponderosae] 462304277 APGK01049550.1 97 1.11024e-40 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q7KQZ4 197 7.9e-14 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF00649 Zinc finger, C2H2 type//Zinc-finger double domain//Copper fist DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003700//GO:0003677//GO:0005507 metal ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding//copper ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.29417 BP_3 3.00 0.35 705 478255334 ENN75560.1 258 5.6e-20 hypothetical protein YQE_07903, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29418 BP_3 496.71 36.70 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29419 BP_3 67.95 2.00 1932 478259274 ENN79176.1 258 1.5e-19 hypothetical protein YQE_04360, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.29423 BP_3 5.00 0.31 1063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29425 BP_3 68.11 0.45 7513 478252915 ENN73299.1 1417 2.4e-153 hypothetical protein YQE_10063, partial [Dendroctonus ponderosae]>gi|546681594|gb|ERL91658.1| hypothetical protein D910_08986, partial [Dendroctonus ponderosae] -- -- -- -- -- K16526 AKAP10 A-kinase anchor protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16526 O88845 730 4.5e-75 A-kinase anchor protein 10, mitochondrial OS=Mus musculus GN=Akap10 PE=1 SV=3 PF02101//PF00002 Ocular albinism type 1 protein//7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.29428 BP_3 108.15 1.55 3661 642936574 XP_008198491.1 1031 6.7e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 3.2e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF10590//PF01243//PF12766//PF02252//PF05175//PF02251 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Proteasome activator pa28 beta subunit//Methyltransferase small domain//Proteasome activator pa28 alpha subunit GO:0008615//GO:0055114 pyridoxine biosynthetic process//oxidation-reduction process GO:0008168//GO:0010181//GO:0004733//GO:0016638 methyltransferase activity//FMN binding//pyridoxamine-phosphate oxidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.29432 BP_3 104.12 2.75 2115 642914509 XP_008201706.1 571 8.4e-56 PREDICTED: transcriptional enhancer factor TEF-1 isoform X1 [Tribolium castaneum] 768436108 XM_011561220.1 138 1.84288e-63 PREDICTED: Plutella xylostella protein scalloped (LOC105390007), transcript variant X4, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P30052 502 3.5e-49 Protein scalloped OS=Drosophila melanogaster GN=sd PE=1 SV=1 PF01285//PF00424 TEA/ATTS domain family//REV protein (anti-repression trans-activator protein) GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005634//GO:0005667 host cell nucleus//nucleus//transcription factor complex KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.29433 BP_3 122.29 2.65 2513 642919790 XP_008192068.1 687 3.6e-69 PREDICTED: uncharacterized protein LOC661416 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12162 UFM1 ubiquitin-fold modifier 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12162 Q7PXE2 221 1.6e-16 Ubiquitin-fold modifier 1 OS=Anopheles gambiae GN=AGAP001364 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3483 Uncharacterized conserved protein Cluster-8309.29434 BP_3 1136.67 14.67 4026 820805540 AKG92761.1 526 2.7e-50 mnt2 [Leptinotarsa decemlineata] 642912790 XM_008203032.1 213 7.17794e-105 PREDICTED: Tribolium castaneum max-interacting protein 1-like (LOC100142502), mRNA K09114 MXD, MAD MAX dimerization protein http://www.genome.jp/dbget-bin/www_bget?ko:K09114 P50538 270 5.3e-22 Max dimerization protein 1 OS=Mus musculus GN=Mxd1 PE=1 SV=2 PF00010//PF07448 Helix-loop-helix DNA-binding domain//Secreted phosphoprotein 24 (Spp-24) GO:0046849 bone remodeling GO:0046983 protein dimerization activity GO:0005576 extracellular region KOG2483 Upstream transcription factor 2/L-myc-2 protein Cluster-8309.29435 BP_3 6.14 0.48 906 91076006 XP_966406.1 279 2.6e-22 PREDICTED: very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014595|gb|EFA11043.1| hypothetical protein TcasGA2_TC004634 [Tribolium castaneum] -- -- -- -- -- K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 P45953 234 1.8e-18 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Acadvl PE=1 SV=1 -- -- GO:0008152 metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.29436 BP_3 19.00 0.44 2350 512921334 XP_004929851.1 1800 2.9e-198 PREDICTED: probable citrate synthase 2, mitochondrial [Bombyx mori] 729734967 XM_010565183.1 411 0 PREDICTED: Haliaeetus leucocephalus citrate synthase (CS), mRNA K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q17GM7 1795 4.5e-199 Probable citrate synthase 1, mitochondrial OS=Aedes aegypti GN=AAEL002956 PE=3 SV=1 PF00285 Citrate synthase -- -- GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer -- -- KOG2617 Citrate synthase Cluster-8309.29438 BP_3 421.00 10.26 2269 224922687 BAH28836.1 2193 7.5e-244 elongation factor 1-alpha [Marsupenaeus japonicus] 393395825 JQ824130.1 1499 0 Scylla paramamosain elongation factor 1A mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P29520 1911 1.5e-212 Elongation factor 1-alpha OS=Bombyx mori PE=2 SV=1 PF04670//PF01926//PF03144 Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.29439 BP_3 25.00 0.36 3633 820839080 XP_012350534.1 349 8.0e-30 PREDICTED: uncharacterized protein LOC100872082 isoform X2 [Apis florea] 262401334 FJ774849.1 242 4.8973e-121 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF04135 Nucleolar RNA-binding protein, Nop10p family GO:0001522//GO:0042254 pseudouridine synthesis//ribosome biogenesis GO:0030515 snoRNA binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.2944 BP_3 39.00 0.71 2926 546674374 ERL85761.1 234 1.4e-16 hypothetical protein D910_03176 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00157 Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.29440 BP_3 25150.39 549.95 2496 546676129 ERL87196.1 501 1.3e-47 hypothetical protein D910_04595 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.29442 BP_3 539.00 6.35 4383 642937102 XP_008198692.1 879 3.4e-91 PREDICTED: uncharacterized protein LOC659902 [Tribolium castaneum]>gi|642937104|ref|XP_008198693.1| PREDICTED: uncharacterized protein LOC659902 [Tribolium castaneum]>gi|270000885|gb|EEZ97332.1| hypothetical protein TcasGA2_TC011144 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DIJ5 210 5.2e-15 High mobility group protein 20A OS=Xenopus tropicalis GN=hmg20a PE=2 SV=1 PF09726//PF00628//PF04111//PF06220 Transmembrane protein//PHD-finger//Autophagy protein Apg6//U1 zinc finger GO:0006914 autophagy GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.29443 BP_3 36.17 1.22 1721 642915724 XP_008190776.1 1099 4.1e-117 PREDICTED: serine/threonine-protein kinase VRK1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q32PI1 400 1.9e-37 Serine/threonine-protein kinase VRK1 OS=Bos taurus GN=VRK1 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.29450 BP_3 121.20 0.77 7920 91091444 XP_972566.1 1855 4.1e-204 PREDICTED: succinate-semialdehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270000977|gb|EEZ97424.1| hypothetical protein TcasGA2_TC011254 [Tribolium castaneum] -- -- -- -- -- K00139 ALDH5A1 succinate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00139 Q3MSM3 1320 1.8e-143 Succinate-semialdehyde dehydrogenase, mitochondrial OS=Hylobates lar GN=ALDH5A1 PE=2 SV=1 PF00171//PF00013 Aldehyde dehydrogenase family//KH domain GO:0006570//GO:0055114//GO:0009450//GO:0008152 tyrosine metabolic process//oxidation-reduction process//gamma-aminobutyric acid catabolic process//metabolic process GO:0016491//GO:0009013//GO:0003723 oxidoreductase activity//succinate-semialdehyde dehydrogenase [NAD(P)+] activity//RNA binding -- -- KOG2451 Aldehyde dehydrogenase Cluster-8309.29451 BP_3 70.72 2.29 1778 91084999 XP_973197.1 1693 5.6e-186 PREDICTED: TBC1 domain family member 10A [Tribolium castaneum]>gi|270009019|gb|EFA05467.1| hypothetical protein TcasGA2_TC015650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHL3 888 5.1e-94 TBC1 domain family member 10B OS=Mus musculus GN=Tbc1d10b PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634//GO:0005622 nucleus//intracellular KOG2221 PDZ-domain interacting protein EPI64, contains TBC domain Cluster-8309.29452 BP_3 417.92 14.02 1728 91084999 XP_973197.1 1693 5.4e-186 PREDICTED: TBC1 domain family member 10A [Tribolium castaneum]>gi|270009019|gb|EFA05467.1| hypothetical protein TcasGA2_TC015650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHL3 888 4.9e-94 TBC1 domain family member 10B OS=Mus musculus GN=Tbc1d10b PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634//GO:0005622 nucleus//intracellular KOG2221 PDZ-domain interacting protein EPI64, contains TBC domain Cluster-8309.29455 BP_3 1136.34 30.07 2113 91078976 XP_974454.1 2314 6.5e-258 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 1006 1.3e-107 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4683 Uncharacterized conserved protein Cluster-8309.29456 BP_3 4.25 0.53 679 91078976 XP_974454.1 619 7.4e-62 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 339 8.9e-31 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4683 Uncharacterized conserved protein Cluster-8309.29458 BP_3 2298.28 70.91 1854 91083699 XP_969478.1 1354 1.2e-146 PREDICTED: periostin [Tribolium castaneum]>gi|270007879|gb|EFA04327.1| hypothetical protein TcasGA2_TC014621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O11780 130 4.2e-06 Transforming growth factor-beta-induced protein ig-h3 OS=Sus scrofa GN=TGFBI PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29461 BP_3 26.96 0.43 3348 642917749 XP_008191355.1 2622 2.0e-293 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q179T2 933 5.8e-99 Exonuclease mut-7 homolog OS=Aedes aegypti GN=AAEL005527 PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding -- -- KOG4373 Predicted 3'-5' exonuclease Cluster-8309.29463 BP_3 30.15 0.50 3173 531447909 AGT57849.1 1618 5.0e-177 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 1015 1.7e-108 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.29465 BP_3 66.90 1.11 3185 531447909 AGT57849.1 1618 5.0e-177 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 1015 1.7e-108 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.29467 BP_3 23.00 1.86 888 642923631 XP_008193582.1 1061 5.4e-113 PREDICTED: aromatic-L-amino-acid decarboxylase-like [Tribolium castaneum]>gi|270006966|gb|EFA03414.1| hypothetical protein TcasGA2_TC013401 [Tribolium castaneum] 158451428 EU032808.1 73 1.02879e-27 Erythromeris flexilineata voucher Eflex putative dopa decarboxylase protein mRNA, partial cds K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 O96571 808 4.8e-85 Aromatic-L-amino-acid decarboxylase (Fragment) OS=Drosophila lebanonensis GN=Ddc PE=3 SV=1 PF05889//PF00155//PF00282//PF01212 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//Aminotransferase class I and II//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase GO:0019752//GO:0009058//GO:0006520 carboxylic acid metabolic process//biosynthetic process//cellular amino acid metabolic process GO:0016831//GO:0016740//GO:0016829//GO:0030170 carboxy-lyase activity//transferase activity//lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.29468 BP_3 15.00 1.46 787 478256140 ENN76339.1 720 1.7e-73 hypothetical protein YQE_07302, partial [Dendroctonus ponderosae] -- -- -- -- -- K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P18486 564 8.3e-57 Alpha-methyldopa hypersensitive protein OS=Drosophila melanogaster GN=amd PE=2 SV=2 PF00282 Pyridoxal-dependent decarboxylase conserved domain GO:0019752 carboxylic acid metabolic process GO:0016831//GO:0030170 carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.29471 BP_3 863.68 6.07 7147 642929299 XP_008195778.1 9649 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 6488 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF00223//PF10152//PF00647//PF08040//PF00514 Photosystem I psaA/psaB protein//Predicted coiled-coil domain-containing protein (DUF2360)//Elongation factor 1 gamma, conserved domain//MNLL subunit//Armadillo/beta-catenin-like repeat GO:0006414//GO:0015979//GO:0006448//GO:0006118 translational elongation//photosynthesis//regulation of translational elongation//obsolete electron transport GO:0005515//GO:0003954//GO:0003746 protein binding//NADH dehydrogenase activity//translation elongation factor activity GO:0016021//GO:0009522//GO:0005840//GO:0071203//GO:0009579//GO:0005739 integral component of membrane//photosystem I//ribosome//WASH complex//thylakoid//mitochondrion KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.29472 BP_3 35.67 0.38 4833 478263448 ENN81809.1 1706 4.7e-187 hypothetical protein YQE_01814, partial [Dendroctonus ponderosae]>gi|478263929|gb|ENN82095.1| hypothetical protein YQE_01527, partial [Dendroctonus ponderosae] 817188109 XM_012433187.1 139 1.18133e-63 PREDICTED: Orussus abietinus tubulin alpha chain-like (LOC105704177), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P81947 862 1.4e-90 Tubulin alpha-1B chain OS=Bos taurus PE=1 SV=2 PF13014//PF05440 KH domain//Tetrahydromethanopterin S-methyltransferase subunit B GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269//GO:0003723 tetrahydromethanopterin S-methyltransferase activity//RNA binding GO:0016021 integral component of membrane KOG1376 Alpha tubulin Cluster-8309.29474 BP_3 42.00 2.46 1113 241671010 XP_002399960.1 527 5.6e-51 60S ribosomal protein L23, putative [Ixodes scapularis]>gi|215506218|gb|EEC15712.1| 60S ribosomal protein L23, putative [Ixodes scapularis] 821485126 XM_003770029.2 91 1.28159e-37 PREDICTED: Sarcophilus harrisii ribosomal protein L23a (RPL23A), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 495 1.2e-48 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0000166 structural constituent of ribosome//nucleotide binding GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.29476 BP_3 165.38 0.92 8952 189233577 XP_968497.2 1756 1.4e-192 PREDICTED: protein capicua homolog isoform X1 [Tribolium castaneum]>gi|270015125|gb|EFA11573.1| capicua [Tribolium castaneum] 642910253 XM_008200351.1 160 4.65104e-75 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X2, mRNA -- -- -- -- Q96RK0 381 1.6e-34 Protein capicua homolog OS=Homo sapiens GN=CIC PE=1 SV=2 PF08288 PIGA (GPI anchor biosynthesis) GO:0006506 GPI anchor biosynthetic process -- -- -- -- KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.29477 BP_3 89.25 1.77 2721 189240236 XP_001811057.1 1062 1.3e-112 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 55 3.27859e-17 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q7ZYD5 739 1.5e-76 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Xenopus laevis GN=slc25a25 PE=2 SV=1 PF03832 WSK motif GO:0007165//GO:0006605 signal transduction//protein targeting -- -- -- -- KOG0036 Predicted mitochondrial carrier protein Cluster-8309.29479 BP_3 93.60 1.73 2892 91076992 XP_975474.1 1215 2.4e-130 PREDICTED: ras-like protein 3 [Tribolium castaneum]>gi|270001761|gb|EEZ98208.1| hypothetical protein TcasGA2_TC000640 [Tribolium castaneum] 195387773 XM_002052531.1 54 1.25429e-16 Drosophila virilis GJ17614 (Dvir\GJ17614), mRNA K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 F1NHE9 770 4.0e-80 ATP-sensitive inward rectifier potassium channel 12 OS=Gallus gallus GN=KCNJ12 PE=1 SV=1 PF08477//PF03193//PF01926//PF00503//PF00025//PF00071//PF01007 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//G-protein alpha subunit//ADP-ribosylation factor family//Ras family//Inward rectifier potassium channel GO:0007264//GO:0007186//GO:0006184//GO:0006813//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//obsolete GTP catabolic process//potassium ion transport//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0005242//GO:0003924//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//inward rectifier potassium channel activity//GTPase activity//G-protein beta/gamma-subunit complex binding GO:0008076//GO:0016020//GO:0016021 voltage-gated potassium channel complex//membrane//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.29480 BP_3 20.42 0.35 3140 189237964 XP_001813896.1 1211 7.7e-130 PREDICTED: Golgi apparatus protein 1 [Tribolium castaneum]>gi|270006658|gb|EFA03106.1| hypothetical protein TcasGA2_TC013016 [Tribolium castaneum] -- -- -- -- -- K06816 GLG1, ESL1 golgi apparatus protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06816 Q92896 757 1.4e-78 Golgi apparatus protein 1 OS=Homo sapiens GN=GLG1 PE=1 SV=2 PF00839//PF12009 Cysteine rich repeat//Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity GO:0016020 membrane KOG3648 Golgi apparatus protein (cysteine-rich fibroblast growth factor receptor) Cluster-8309.29481 BP_3 329.72 9.96 1888 91091366 XP_972690.1 965 1.6e-101 PREDICTED: tRNA methyltransferase 10 homolog A [Tribolium castaneum]>gi|270014152|gb|EFA10600.1| hypothetical protein TcasGA2_TC012861 [Tribolium castaneum] -- -- -- -- -- K15445 TRMT10A, TRM10, RG9MTD2 tRNA (guanine9-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15445 Q8TBZ6 466 4.6e-45 tRNA methyltransferase 10 homolog A OS=Homo sapiens GN=TRMT10A PE=1 SV=1 -- -- GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2967 Uncharacterized conserved protein Cluster-8309.29482 BP_3 26.23 0.61 2365 546685745 ERL95200.1 301 1.9e-24 hypothetical protein D910_12468 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08463 EcoEI R protein C-terminal GO:0006304 DNA modification GO:0003677//GO:0003824 DNA binding//catalytic activity -- -- -- -- Cluster-8309.29483 BP_3 1010.71 6.74 7516 642939434 XP_008200389.1 4154 0.0e+00 PREDICTED: pumilio homolog 2 isoform X2 [Tribolium castaneum] 642939433 XM_008202167.1 727 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806//PF02422 CPL (NUC119) domain//Pumilio-family RNA binding repeat//Keratin -- -- GO:0003723//GO:0005200 RNA binding//structural constituent of cytoskeleton GO:0005882//GO:0005856 intermediate filament//cytoskeleton KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.29484 BP_3 32124.00 8818.32 467 16226511 AAL16187.1 447 4.4e-42 larval cuticle protein precursor [Apriona germari] 16226510 AF428097.1 245 1.27123e-123 Apriona germari larval cuticle protein precursor (LCP10.7) mRNA, complete cds -- -- -- -- P45589 303 9.1e-27 Flexible cuticle protein 12 OS=Hyalophora cecropia GN=CP12 PE=2 SV=1 PF13545//PF00379 Crp-like helix-turn-helix domain//Insect cuticle protein GO:0006355 regulation of transcription, DNA-templated GO:0042302//GO:0003677 structural constituent of cuticle//DNA binding -- -- -- -- Cluster-8309.29486 BP_3 18.36 0.48 2138 642921732 XP_008199304.1 436 3.9e-40 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 338 3.7e-30 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.29487 BP_3 32.98 0.58 3038 478253166 ENN73537.1 200 1.3e-12 hypothetical protein YQE_09788, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 158 3.9e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF04183//PF02892 Zinc finger, C2H2 type//IucA / IucC family//BED zinc finger GO:0019290//GO:0006826 siderophore biosynthetic process//iron ion transport GO:0003677//GO:0015343//GO:0046872 DNA binding//siderophore transmembrane transporter activity//metal ion binding -- -- -- -- Cluster-8309.29489 BP_3 7.00 0.42 1086 751461201 XP_011185396.1 178 1.6e-10 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- D2WKD9 130 2.4e-06 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2949 BP_3 2737.46 35.74 3983 546684191 ERL93896.1 1257 4.5e-135 hypothetical protein D910_11182, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P54316 373 6.0e-34 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29490 BP_3 137.31 7.66 1156 642926052 XP_970129.2 670 1.5e-67 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 222 5.6e-17 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29491 BP_3 2.51 0.35 635 270004614 EFA01062.1 289 1.3e-23 hypothetical protein TcasGA2_TC003980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q76LL6 171 2.5e-11 FH1/FH2 domain-containing protein 3 OS=Mus musculus GN=Fhod3 PE=1 SV=1 PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family -- -- GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1925 Rac1 GTPase effector FHOS Cluster-8309.29492 BP_3 5142.61 88.77 3084 478263298 ENN81679.1 668 7.0e-67 hypothetical protein YQE_01931, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF10717//PF03110 Chitin binding Peritrophin-A domain//Occlusion-derived virus envelope protein ODV-E18//SBP domain GO:0006030 chitin metabolic process GO:0008061//GO:0003677 chitin binding//DNA binding GO:0019031//GO:0005634//GO:0005576 viral envelope//nucleus//extracellular region -- -- Cluster-8309.29493 BP_3 1279.66 111.48 845 270297218 NP_001161918.1 687 1.2e-69 cuticular protein analogous to peritrophins 1-H precursor [Tribolium castaneum]>gi|642929138|ref|XP_008195708.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|642929140|ref|XP_008195709.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|268309014|gb|ACY95473.1| cuticular protein analogous to peritrophins 1-H [Tribolium castaneum]>gi|270010495|gb|EFA06943.1| hypothetical protein TcasGA2_TC009894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.29496 BP_3 60.55 1.26 2615 332376210 AEE63245.1 1434 8.9e-156 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XJP1 768 6.2e-80 Protein TSSC1 OS=Danio rerio GN=tssc1 PE=2 SV=1 PF00400//PF03121//PF01215 WD domain, G-beta repeat//Herpesviridae UL52/UL70 DNA primase//Cytochrome c oxidase subunit Vb GO:0006269//GO:0006260//GO:0015992//GO:0006351//GO:0006123 DNA replication, synthesis of RNA primer//DNA replication//proton transport//transcription, DNA-templated//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003896//GO:0005515 cytochrome-c oxidase activity//DNA primase activity//protein binding GO:0005740//GO:0005730//GO:0005657//GO:0045277 mitochondrial envelope//nucleolus//replication fork//respiratory chain complex IV KOG1007 WD repeat protein TSSC1, WD repeat superfamily Cluster-8309.29498 BP_3 522.58 11.17 2547 332376210 AEE63245.1 1539 5.8e-168 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XJP1 844 9.2e-89 Protein TSSC1 OS=Danio rerio GN=tssc1 PE=2 SV=1 PF00400//PF01215 WD domain, G-beta repeat//Cytochrome c oxidase subunit Vb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0005515 cytochrome-c oxidase activity//protein binding GO:0045277//GO:0005740 respiratory chain complex IV//mitochondrial envelope KOG1007 WD repeat protein TSSC1, WD repeat superfamily Cluster-8309.295 BP_3 6.00 0.33 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29500 BP_3 12.00 1.37 713 642931274 XP_008196509.1 326 7.3e-28 PREDICTED: myosin heavy chain, muscle isoform X3 [Tribolium castaneum] 755853805 XM_011297467.1 128 2.17976e-58 PREDICTED: Musca domestica myosin heavy chain, muscle (LOC101893508), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 309 2.8e-27 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0161 Myosin class II heavy chain Cluster-8309.29502 BP_3 1284.17 14.69 4506 642916693 XP_008192186.1 4445 0.0e+00 PREDICTED: membrane-bound transcription factor site-1 protease isoform X2 [Tribolium castaneum] 768954933 XM_003976835.2 102 4.07281e-43 PREDICTED: Takifugu rubripes membrane-bound transcription factor site-1 protease-like (LOC101078346), partial mRNA K08653 MBTPS1 membrane-bound transcription factor site-1 protease http://www.genome.jp/dbget-bin/www_bget?ko:K08653 Q9Z2A8 3338 0.0e+00 Membrane-bound transcription factor site-1 protease OS=Cricetulus griseus GN=MBTPS1 PE=1 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.29504 BP_3 498.49 6.75 3853 189240839 XP_001812334.1 2667 1.4e-298 PREDICTED: SWI/SNF complex subunit SMARCC2 [Tribolium castaneum]>gi|270013718|gb|EFA10166.1| hypothetical protein TcasGA2_TC012356 [Tribolium castaneum] 585702584 XM_006897683.1 41 2.82503e-09 PREDICTED: Elephantulus edwardii SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), mRNA K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q92922 1625 3.8e-179 SWI/SNF complex subunit SMARCC1 OS=Homo sapiens GN=SMARCC1 PE=1 SV=3 PF04433 SWIRM domain -- -- GO:0005488//GO:0005515 binding//protein binding -- -- KOG1279 Chromatin remodeling factor subunit and related transcription factors Cluster-8309.29509 BP_3 35.53 0.40 4551 642923468 XP_008193757.1 632 1.5e-62 PREDICTED: glia maturation factor beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49858 447 1.8e-42 Protein cornichon OS=Drosophila melanogaster GN=cni PE=1 SV=1 PF00241//PF03311 Cofilin/tropomyosin-type actin-binding protein//Cornichon protein GO:0035556 intracellular signal transduction GO:0003779 actin binding GO:0016020//GO:0005622 membrane//intracellular KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.2951 BP_3 1516.32 20.08 3931 270005705 EFA02153.1 583 6.4e-57 hypothetical protein TcasGA2_TC007806 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29510 BP_3 27.00 4.32 593 189238225 XP_970862.2 257 6.1e-20 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414 TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29511 BP_3 436.55 5.72 3972 546685279 ERL94806.1 3262 0.0e+00 hypothetical protein D910_12080 [Dendroctonus ponderosae] 815898007 XM_003485762.2 360 0 PREDICTED: Bombus impatiens cullin-4A (LOC100740815), mRNA K10609 CUL4 cullin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10609 A2A432 2575 2.7e-289 Cullin-4B OS=Mus musculus GN=Cul4b PE=1 SV=1 PF00888//PF07516 Cullin family//SecA Wing and Scaffold domain GO:0006511//GO:0017038 ubiquitin-dependent protein catabolic process//protein import GO:0031625 ubiquitin protein ligase binding GO:0016020 membrane KOG2166 Cullins Cluster-8309.29512 BP_3 59.71 1.18 2728 642932076 XP_008196848.1 1166 1.1e-124 PREDICTED: pre-mRNA-splicing regulator female-lethal(2)D [Tribolium castaneum]>gi|270011667|gb|EFA08115.1| hypothetical protein TcasGA2_TC005719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y091 702 2.9e-72 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila melanogaster GN=fl(2)d PE=1 SV=2 PF02932//PF05791//PF17098//PF03233//PF09298//PF07361//PF02050//PF09177 Neurotransmitter-gated ion-channel transmembrane region//Bacillus haemolytic enterotoxin (HBL)//Pre-mRNA-splicing regulator WTAP//Aphid transmission protein//Fumarylacetoacetase N-terminal//Cytochrome b562//Flagellar FliJ protein//Syntaxin 6, N-terminal GO:0006570//GO:0009405//GO:0042207//GO:0022900//GO:0006118//GO:0009072//GO:0071973//GO:0048193//GO:0019089//GO:0006935//GO:0006811//GO:0048024 tyrosine metabolic process//pathogenesis//styrene catabolic process//electron transport chain//obsolete electron transport//aromatic amino acid family metabolic process//bacterial-type flagellum-dependent cell motility//Golgi vesicle transport//transmission of virus//chemotaxis//ion transport//regulation of mRNA splicing, via spliceosome GO:0005506//GO:0020037//GO:0004334//GO:0009055//GO:0003774 iron ion binding//heme binding//fumarylacetoacetase activity//electron carrier activity//motor activity GO:0042597//GO:0009288//GO:0005634//GO:0016020 periplasmic space//bacterial-type flagellum//nucleus//membrane KOG2991 Splicing regulator Cluster-8309.29513 BP_3 364.32 5.83 3305 478257765 ENN77908.1 1133 9.0e-121 hypothetical protein YQE_05585, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y091 696 1.7e-71 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila melanogaster GN=fl(2)d PE=1 SV=2 PF17098//PF04977//PF05791//PF06156//PF01496//PF11744//PF06005//PF09177//PF04799 Pre-mRNA-splicing regulator WTAP//Septum formation initiator//Bacillus haemolytic enterotoxin (HBL)//Protein of unknown function (DUF972)//V-type ATPase 116kDa subunit family//Aluminium activated malate transporter//Protein of unknown function (DUF904)//Syntaxin 6, N-terminal//fzo-like conserved region GO:0015991//GO:0048193//GO:0015743//GO:0000917//GO:0043093//GO:0048024//GO:0008053//GO:0009405//GO:0007049//GO:0015992//GO:0006260 ATP hydrolysis coupled proton transport//Golgi vesicle transport//malate transport//barrier septum assembly//FtsZ-dependent cytokinesis//regulation of mRNA splicing, via spliceosome//mitochondrial fusion//pathogenesis//cell cycle//proton transport//DNA replication GO:0003924//GO:0015078 GTPase activity//hydrogen ion transmembrane transporter activity GO:0005634//GO:0033179//GO:0016020//GO:0005741//GO:0016021//GO:0005737 nucleus//proton-transporting V-type ATPase, V0 domain//membrane//mitochondrial outer membrane//integral component of membrane//cytoplasm KOG2991 Splicing regulator Cluster-8309.29514 BP_3 5324.08 246.21 1334 264667437 ACY71304.1 658 4.3e-66 ribosomal protein S17 [Chrysomela tremula] 780657916 XM_011693770.1 153 5.27945e-72 PREDICTED: Wasmannia auropunctata 40S ribosomal protein S17 (LOC105452559), mRNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 Q962R2 595 3.6e-60 40S ribosomal protein S17 OS=Spodoptera frugiperda GN=RpS17 PE=2 SV=3 PF02175//PF00833 Serpentine type 7TM GPCR chemoreceptor Srb//Ribosomal S17 GO:0007606//GO:0042254//GO:0007165//GO:0006412 sensory perception of chemical stimulus//ribosome biogenesis//signal transduction//translation GO:0003735//GO:0004888 structural constituent of ribosome//transmembrane signaling receptor activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG0187 40S ribosomal protein S17 Cluster-8309.29515 BP_3 18.98 0.35 2917 642928332 XP_008195538.1 982 2.6e-103 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81139 364 4.8e-33 Pancreatic lipase-related protein 2 OS=Cavia porcellus GN=PNLIPRP2 PE=1 SV=1 PF01764//PF07859//PF06821//PF00326//PF07819//PF00975 Lipase (class 3)//alpha/beta hydrolase fold//Serine hydrolase//Prolyl oligopeptidase family//PGAP1-like protein//Thioesterase domain GO:0006505//GO:0008152//GO:0006629//GO:0006886//GO:0006508//GO:0009058 GPI anchor metabolic process//metabolic process//lipid metabolic process//intracellular protein transport//proteolysis//biosynthetic process GO:0016788//GO:0003824//GO:0016787//GO:0008236 hydrolase activity, acting on ester bonds//catalytic activity//hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.29517 BP_3 16.61 0.77 1329 642927976 XP_008195469.1 559 1.3e-54 PREDICTED: leptin receptor gene-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3Y064 375 1.2e-34 Leptin receptor gene-related protein OS=Takifugu rubripes GN=leprot PE=2 SV=1 PF07440//PF07155 Caerin 1 protein//ECF-type riboflavin transporter, S component -- -- -- -- GO:0016020//GO:0005576 membrane//extracellular region KOG2174 Leptin receptor gene-related protein Cluster-8309.29518 BP_3 752.77 8.46 4580 91094045 XP_968644.1 1387 4.4e-150 PREDICTED: RNA-binding protein 12 [Tribolium castaneum]>gi|270003124|gb|EEZ99571.1| hypothetical protein TcasGA2_TC001555 [Tribolium castaneum] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 Q9VHR6 650 5.2e-66 Autophagy-related protein 13 homolog OS=Drosophila melanogaster GN=Atg13 PE=1 SV=1 PF06459//PF00076//PF08777 Ryanodine Receptor TM 4-6//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219//GO:0003723//GO:0003676 ryanodine-sensitive calcium-release channel activity//RNA binding//nucleic acid binding GO:0016021//GO:0005622 integral component of membrane//intracellular KOG4307 RNA binding protein RBM12/SWAN Cluster-8309.2952 BP_3 2.59 0.65 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00242 DNA polymerase (viral) N-terminal domain GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.29520 BP_3 1504.64 29.39 2759 91089337 XP_972494.1 2610 4.0e-292 PREDICTED: protein singed [Tribolium castaneum]>gi|270012518|gb|EFA08966.1| hypothetical protein TcasGA2_TC006673 [Tribolium castaneum] 642933078 XM_967401.2 574 0 PREDICTED: Tribolium castaneum protein singed (LOC661226), mRNA K17455 FSCN1_2 fascin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17455 Q24524 1954 1.9e-217 Protein singed OS=Drosophila melanogaster GN=sn PE=3 SV=1 PF01786//PF06268//PF00167 Alternative oxidase//Fascin domain//Fibroblast growth factor GO:0055114//GO:0006118//GO:0008283//GO:0007165//GO:0040007 oxidation-reduction process//obsolete electron transport//cell proliferation//signal transduction//growth GO:0051015//GO:0030674//GO:0009916//GO:0008083 actin filament binding//protein binding, bridging//alternative oxidase activity//growth factor activity -- -- -- -- Cluster-8309.29521 BP_3 38.13 4.91 666 642939867 XP_969882.2 715 5.3e-73 PREDICTED: alpha-aminoadipic semialdehyde dehydrogenase [Tribolium castaneum] -- -- -- -- -- K14085 ALDH7A1 aldehyde dehydrogenase family 7 member A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14085 P46562 537 9.6e-54 Putative aldehyde dehydrogenase family 7 member A1 homolog OS=Caenorhabditis elegans GN=alh-9 PE=3 SV=2 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2453 Aldehyde dehydrogenase Cluster-8309.29524 BP_3 39.00 9.42 491 642915198 XP_008190515.1 286 2.2e-23 PREDICTED: protein phosphatase 1 regulatory subunit 12B-like isoform X5 [Tribolium castaneum] 642915197 XM_008192293.1 159 8.60471e-76 PREDICTED: Tribolium castaneum protein phosphatase 1 regulatory subunit 12B-like (LOC659634), transcript variant X5, mRNA K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 O60237 160 3.7e-10 Protein phosphatase 1 regulatory subunit 12B OS=Homo sapiens GN=PPP1R12B PE=1 SV=2 PF04612//PF15898//PF03462//PF06495//PF06156//PF04111//PF02183//PF08912//PF05837//PF03938//PF03480//PF08172//PF16326//PF04977//PF05478//PF02662 Type II secretion system (T2SS), protein M//cGMP-dependent protein kinase interacting domain//PCRF domain//Fruit fly transformer protein//Protein of unknown function (DUF972)//Autophagy protein Apg6//Homeobox associated leucine zipper//Rho Binding//Centromere protein H (CENP-H)//Outer membrane protein (OmpH-like)//Bacterial extracellular solute-binding protein, family 7//CASP C terminal//ABC transporter C-terminal domain//Septum formation initiator//Prominin//Methyl-viologen-reducing hydrogenase, delta subunit GO:0006891//GO:0006397//GO:0015948//GO:0006449//GO:0051382//GO:0006810//GO:0006914//GO:0006260//GO:0006415//GO:0006355//GO:0006858//GO:0007049//GO:0055114//GO:0046660 intra-Golgi vesicle-mediated transport//mRNA processing//methanogenesis//regulation of translational termination//kinetochore assembly//transport//autophagy//DNA replication//translational termination//regulation of transcription, DNA-templated//extracellular transport//cell cycle//oxidation-reduction process//female sex differentiation GO:0003677//GO:0016149//GO:0017048//GO:0019901//GO:0043565//GO:0051082//GO:0003700 DNA binding//translation release factor activity, codon specific//Rho GTPase binding//protein kinase binding//sequence-specific DNA binding//unfolded protein binding//transcription factor activity, sequence-specific DNA binding GO:0030288//GO:0005634//GO:0005667//GO:0030173//GO:0000776//GO:0016021//GO:0005840//GO:0005737//GO:0018444 outer membrane-bounded periplasmic space//nucleus//transcription factor complex//integral component of Golgi membrane//kinetochore//integral component of membrane//ribosome//cytoplasm//translation release factor complex KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.29525 BP_3 32.00 5.35 580 665788819 XP_008560020.1 135 8.3e-06 PREDICTED: protein phosphatase 1 regulatory subunit 12A-like isoform X4 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29526 BP_3 1300.88 9.13 7162 91087897 XP_970459.1 859 1.2e-88 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270012016|gb|EFA08464.1| hypothetical protein TcasGA2_TC006113 [Tribolium castaneum] 642930872 XM_965366.2 96 1.40481e-39 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 1.6e-16 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF05495//PF11808 CHY zinc finger//Domain of unknown function (DUF3329) GO:0016310 phosphorylation GO:0008270//GO:0004673 zinc ion binding//protein histidine kinase activity GO:0009365 protein histidine kinase complex -- -- Cluster-8309.29527 BP_3 852.76 21.21 2230 478258110 ENN78248.1 2252 1.1e-250 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] -- -- -- -- -- K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 Q6S9C8 1436 1.8e-157 Leukotriene A-4 hydrolase OS=Chinchilla lanigera GN=LTA4H PE=2 SV=3 PF09127//PF01433//PF01435 Leukotriene A4 hydrolase, C-terminal//Peptidase family M1//Peptidase family M48 GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0004222//GO:0008270//GO:0008237 metalloendopeptidase activity//zinc ion binding//metallopeptidase activity -- -- KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.29529 BP_3 281.20 3.21 4512 478258110 ENN78248.1 2446 6.9e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 3.64182e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 2.6e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF09127//PF01433//PF01435//PF00400//PF08063 Leukotriene A4 hydrolase, C-terminal//Peptidase family M1//Peptidase family M48//WD domain, G-beta repeat//PADR1 (NUC008) domain GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0005515//GO:0004222//GO:0003950//GO:0008270//GO:0008237 protein binding//metalloendopeptidase activity//NAD+ ADP-ribosyltransferase activity//zinc ion binding//metallopeptidase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.2953 BP_3 4747.00 1341.04 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29532 BP_3 140.03 2.84 2670 546676927 ERL87851.1 1793 2.1e-197 hypothetical protein D910_05239 [Dendroctonus ponderosae] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 728 2.7e-75 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.29533 BP_3 25.08 0.35 3746 642922443 XP_008193171.1 1690 2.6e-185 PREDICTED: glucose-6-phosphate dehydrogenase isoform X2 [Tribolium castaneum] 642922836 XM_008195125.1 330 6.08779e-170 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X1, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P41571 1444 3.6e-158 Glucose-6-phosphate 1-dehydrogenase OS=Ceratitis capitata GN=ZW PE=2 SV=1 PF00479//PF00180//PF02781 Glucose-6-phosphate dehydrogenase, NAD binding domain//Isocitrate/isopropylmalate dehydrogenase//Glucose-6-phosphate dehydrogenase, C-terminal domain GO:0055114//GO:0006098//GO:0006749//GO:0006006 oxidation-reduction process//pentose-phosphate shunt//glutathione metabolic process//glucose metabolic process GO:0016616//GO:0004345//GO:0050661 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glucose-6-phosphate dehydrogenase activity//NADP binding -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.29534 BP_3 52.98 1.96 1595 642922837 XP_008193347.1 1287 6.0e-139 PREDICTED: isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like isoform X1 [Tribolium castaneum]>gi|270007569|gb|EFA04017.1| hypothetical protein TcasGA2_TC014166 [Tribolium castaneum] 642922838 XM_968977.2 264 1.25183e-133 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X2, mRNA K00030 IDH3 isocitrate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00030 P41565 732 5.6e-76 Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial OS=Rattus norvegicus GN=Idh3g PE=2 SV=2 PF00180 Isocitrate/isopropylmalate dehydrogenase GO:0055114//GO:0006099 oxidation-reduction process//tricarboxylic acid cycle GO:0000287//GO:0004449//GO:0016616//GO:0051287 magnesium ion binding//isocitrate dehydrogenase (NAD+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG0784 Isocitrate dehydrogenase, gamma subunit Cluster-8309.29535 BP_3 2.00 0.73 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29537 BP_3 88.52 1.29 3605 642936574 XP_008198491.1 1031 6.6e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 3.1e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF05175//PF02251//PF01243//PF12766//PF02252//PF10590 Methyltransferase small domain//Proteasome activator pa28 alpha subunit//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Proteasome activator pa28 beta subunit//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region GO:0055114//GO:0008615 oxidation-reduction process//pyridoxine biosynthetic process GO:0004733//GO:0016638//GO:0010181//GO:0008168 pyridoxamine-phosphate oxidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//FMN binding//methyltransferase activity GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.29540 BP_3 42.85 0.57 3910 642932262 XP_008197037.1 3714 0.0e+00 PREDICTED: exosome complex exonuclease RRP44 [Tribolium castaneum]>gi|270012315|gb|EFA08763.1| hypothetical protein TcasGA2_TC006450 [Tribolium castaneum] 642932261 XM_008198815.1 517 0 PREDICTED: Tribolium castaneum exosome complex exonuclease RRP44 (LOC655788), mRNA K12585 DIS3, RRP44 exosome complex exonuclease DIS3/RRP44 http://www.genome.jp/dbget-bin/www_bget?ko:K12585 Q9Y2L1 2458 1.0e-275 Exosome complex exonuclease RRP44 OS=Homo sapiens GN=DIS3 PE=1 SV=2 -- -- GO:0051252 regulation of RNA metabolic process GO:0004540//GO:0003723 ribonuclease activity//RNA binding -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-8309.29541 BP_3 138.29 1.88 3839 642932262 XP_008197037.1 3943 0.0e+00 PREDICTED: exosome complex exonuclease RRP44 [Tribolium castaneum]>gi|270012315|gb|EFA08763.1| hypothetical protein TcasGA2_TC006450 [Tribolium castaneum] 642932261 XM_008198815.1 549 0 PREDICTED: Tribolium castaneum exosome complex exonuclease RRP44 (LOC655788), mRNA K12585 DIS3, RRP44 exosome complex exonuclease DIS3/RRP44 http://www.genome.jp/dbget-bin/www_bget?ko:K12585 Q9Y2L1 2571 7.7e-289 Exosome complex exonuclease RRP44 OS=Homo sapiens GN=DIS3 PE=1 SV=2 -- -- GO:0051252 regulation of RNA metabolic process GO:0003723//GO:0004540 RNA binding//ribonuclease activity -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-8309.29542 BP_3 1.00 0.34 433 332374764 AEE62523.1 261 1.5e-20 unknown [Dendroctonus ponderosae] -- -- -- -- -- K06126 COQ6 ubiquinone biosynthesis monooxygenase Coq6 http://www.genome.jp/dbget-bin/www_bget?ko:K06126 Q6DF46 185 4.1e-13 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Xenopus tropicalis GN=coq6 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3855 Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis Cluster-8309.29544 BP_3 689.68 9.63 3745 859132811 AKO63319.1 3478 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2391 5.6e-268 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF00368//PF00487//PF02460 Hydroxymethylglutaryl-coenzyme A reductase//Fatty acid desaturase//Patched family GO:0007165//GO:0006629//GO:0006694//GO:0055114//GO:0015936 signal transduction//lipid metabolic process//steroid biosynthetic process//oxidation-reduction process//coenzyme A metabolic process GO:0050662//GO:0008158//GO:0004420 coenzyme binding//hedgehog receptor activity//hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0016020 membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.29545 BP_3 27.43 0.75 2058 642914174 XP_008201575.1 477 6.5e-45 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15182 Otospiralin GO:0007605 sensory perception of sound -- -- -- -- -- -- Cluster-8309.29547 BP_3 382.18 4.90 4050 642938314 XP_008192827.1 891 1.3e-92 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X7 [Tribolium castaneum] 642938313 XM_008194605.1 199 4.37685e-97 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X8, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 Q9VWW0 282 2.2e-23 Cyclic AMP response element-binding protein B OS=Drosophila melanogaster GN=CrebB PE=1 SV=1 PF02173//PF00170//PF07716//PF03131 pKID domain//bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700//GO:0005515 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.29548 BP_3 9.00 0.31 1710 642920914 XP_008192613.1 325 2.3e-27 PREDICTED: outer dense fiber protein 3-B isoform X2 [Tribolium castaneum]>gi|270006132|gb|EFA02580.1| hypothetical protein TcasGA2_TC008298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 149 2.4e-08 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.29549 BP_3 60.70 1.59 2133 642934494 XP_008197688.1 2299 3.6e-256 PREDICTED: proteasome-associated protein ECM29 homolog [Tribolium castaneum] -- -- -- -- -- K11886 ECM29 proteasome component ECM29 http://www.genome.jp/dbget-bin/www_bget?ko:K11886 Q5VYK3 1105 4.2e-119 Proteasome-associated protein ECM29 homolog OS=Homo sapiens GN=ECM29 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0915 Uncharacterized conserved protein Cluster-8309.2955 BP_3 111.01 16.25 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03967 Photosynthetic reaction centre, H-chain N-terminal region GO:0019684//GO:0006118 photosynthesis, light reaction//obsolete electron transport GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GO:0030077 plasma membrane light-harvesting complex -- -- Cluster-8309.29550 BP_3 1342.01 12.04 5662 642934494 XP_008197688.1 6774 0.0e+00 PREDICTED: proteasome-associated protein ECM29 homolog [Tribolium castaneum] -- -- -- -- -- K11886 ECM29 proteasome component ECM29 http://www.genome.jp/dbget-bin/www_bget?ko:K11886 Q5VYK3 3099 0.0e+00 Proteasome-associated protein ECM29 homolog OS=Homo sapiens GN=ECM29 PE=1 SV=2 PF08064//PF02985 UME (NUC010) domain//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0005515 protein serine/threonine kinase activity//protein binding -- -- KOG0915 Uncharacterized conserved protein Cluster-8309.29551 BP_3 44.75 0.39 5780 642934494 XP_008197688.1 6070 0.0e+00 PREDICTED: proteasome-associated protein ECM29 homolog [Tribolium castaneum] -- -- -- -- -- K11886 ECM29 proteasome component ECM29 http://www.genome.jp/dbget-bin/www_bget?ko:K11886 Q5VYK3 2864 0.0e+00 Proteasome-associated protein ECM29 homolog OS=Homo sapiens GN=ECM29 PE=1 SV=2 PF08064//PF02985//PF01602//PF00121 UME (NUC010) domain//HEAT repeat//Adaptin N terminal region//Triosephosphate isomerase GO:0015976//GO:0006013//GO:0008152//GO:0006020//GO:0016310//GO:0006094//GO:0046486//GO:0006000//GO:0006096//GO:0016192//GO:0006886//GO:0009069 carbon utilization//mannose metabolic process//metabolic process//inositol metabolic process//phosphorylation//gluconeogenesis//glycerolipid metabolic process//fructose metabolic process//glycolytic process//vesicle-mediated transport//intracellular protein transport//serine family amino acid metabolic process GO:0005515//GO:0004674//GO:0004807 protein binding//protein serine/threonine kinase activity//triose-phosphate isomerase activity GO:0030117 membrane coat KOG0915 Uncharacterized conserved protein Cluster-8309.29555 BP_3 74.89 4.92 1025 91087501 XP_968536.1 536 4.7e-52 PREDICTED: DNA replication complex GINS protein PSF3 [Tribolium castaneum]>gi|270010665|gb|EFA07113.1| hypothetical protein TcasGA2_TC010104 [Tribolium castaneum] -- -- -- -- -- K10734 GINS3 GINS complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10734 Q5RDV0 230 5.8e-18 DNA replication complex GINS protein PSF3 OS=Pongo abelii GN=GINS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29557 BP_3 184.60 4.36 2334 478259929 ENN79731.1 755 4.3e-77 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 408 3.1e-38 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.29558 BP_3 15.34 0.60 1516 642912660 XP_008200953.1 883 4.0e-92 PREDICTED: aldose reductase-like [Tribolium castaneum]>gi|270002625|gb|EEZ99072.1| hypothetical protein TcasGA2_TC004950 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 Q91WR5 436 1.1e-41 Aldo-keto reductase family 1 member C21 OS=Mus musculus GN=Akr1c21 PE=1 SV=2 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.29559 BP_3 217.78 3.04 3743 91090802 XP_970620.1 877 4.9e-91 PREDICTED: ran-binding protein 3 isoform X1 [Tribolium castaneum]>gi|270013975|gb|EFA10423.1| hypothetical protein TcasGA2_TC012664 [Tribolium castaneum] -- -- -- -- -- K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 Q5ZMQ9 522 3.0e-51 Peroxisomal targeting signal 1 receptor OS=Gallus gallus GN=PEX5 PE=2 SV=1 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG1125 TPR repeat-containing protein Cluster-8309.29560 BP_3 15.72 1.29 878 478253691 ENN73990.1 304 3.2e-25 hypothetical protein YQE_09380, partial [Dendroctonus ponderosae]>gi|546682630|gb|ERL92545.1| hypothetical protein D910_09858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.29561 BP_3 37.20 0.40 4796 642923524 XP_008193545.1 3298 0.0e+00 PREDICTED: anoctamin-5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q32M45 1428 3.3e-156 Anoctamin-4 OS=Homo sapiens GN=ANO4 PE=2 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- KOG2514 Uncharacterized conserved protein Cluster-8309.29564 BP_3 179.97 2.73 3466 478254798 ENN75034.1 1443 1.1e-156 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 167 2.29922e-79 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 980 2.1e-104 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.29565 BP_3 1487.61 29.81 2697 383864945 XP_003707938.1 1685 7.2e-185 PREDICTED: guanine nucleotide-binding protein G(i) subunit alpha [Megachile rotundata] 766921600 XM_011507026.1 214 1.33099e-105 PREDICTED: Ceratosolen solmsi marchali guanine nucleotide-binding protein G(i) subunit alpha-like (LOC105368111), mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 P41776 1581 3.4e-174 Guanine nucleotide-binding protein G(i) subunit alpha OS=Homarus americanus PE=2 SV=2 PF00503//PF00025//PF04670//PF08477 G-protein alpha subunit//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0019001//GO:0004871//GO:0005525//GO:0031683//GO:0003924 guanyl nucleotide binding//signal transducer activity//GTP binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.29566 BP_3 4.00 1.19 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29568 BP_3 59.06 0.65 4675 642919028 XP_008191703.1 2327 4.5e-259 PREDICTED: MAGUK p55 subfamily member 5-A isoform X1 [Tribolium castaneum] 642919029 XM_008193482.1 122 3.22161e-54 PREDICTED: Tribolium castaneum MAGUK p55 subfamily member 5-A (LOC663614), transcript variant X2, mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 Q8N3R9 1150 5.6e-124 MAGUK p55 subfamily member 5 OS=Homo sapiens GN=MPP5 PE=1 SV=3 PF13180//PF14604//PF00018//PF00595 PDZ domain//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.2957 BP_3 13.00 0.47 1618 91084843 XP_966905.1 1303 8.5e-141 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 787 2.4e-82 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 PF03015//PF01073//PF05413//PF01118//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//Putative closterovirus papain-like endopeptidase//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0006144//GO:0008210//GO:0019079//GO:0008209//GO:0055114//GO:0006694//GO:0008207 purine nucleobase metabolic process//estrogen metabolic process//viral genome replication//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0051287//GO:0003824//GO:0003723//GO:0003968//GO:0016616//GO:0005524//GO:0050662//GO:0003854//GO:0016620//GO:0080019 NAD binding//catalytic activity//RNA binding//RNA-directed RNA polymerase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//ATP binding//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity GO:0031379 RNA-directed RNA polymerase complex KOG1221 Acyl-CoA reductase Cluster-8309.29571 BP_3 66.52 0.36 9291 91076206 XP_972459.1 2316 1.7e-257 PREDICTED: KN motif and ankyrin repeat domain-containing protein 2 [Tribolium castaneum]>gi|270014552|gb|EFA11000.1| hypothetical protein TcasGA2_TC004585 [Tribolium castaneum] 759076887 XM_011349892.1 70 5.18182e-25 PREDICTED: Cerapachys biroi KN motif and ankyrin repeat domain-containing protein 2-like (LOC105285603), transcript variant X3, mRNA -- -- -- -- Q14678 663 3.3e-67 KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens GN=KANK1 PE=1 SV=3 PF15182//PF00628//PF07649//PF13606//PF00130//PF13939//PF00023//PF15898//PF01300 Otospiralin//PHD-finger//C1-like domain//Ankyrin repeat//Phorbol esters/diacylglycerol binding domain (C1 domain)//Toxin TisB, type I toxin-antitoxin system//Ankyrin repeat//cGMP-dependent protein kinase interacting domain//Telomere recombination GO:0007605//GO:0009432//GO:0006820//GO:0022611//GO:0055114//GO:0035556 sensory perception of sound//SOS response//anion transport//dormancy process//oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0019901//GO:0005253//GO:0047134//GO:0003725 protein binding//protein kinase binding//anion channel activity//protein-disulfide reductase activity//double-stranded RNA binding GO:0005887 integral component of plasma membrane KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.29573 BP_3 62.75 0.35 8952 91076206 XP_972459.1 2316 1.6e-257 PREDICTED: KN motif and ankyrin repeat domain-containing protein 2 [Tribolium castaneum]>gi|270014552|gb|EFA11000.1| hypothetical protein TcasGA2_TC004585 [Tribolium castaneum] 759076887 XM_011349892.1 70 4.99199e-25 PREDICTED: Cerapachys biroi KN motif and ankyrin repeat domain-containing protein 2-like (LOC105285603), transcript variant X3, mRNA -- -- -- -- Q14678 663 3.2e-67 KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens GN=KANK1 PE=1 SV=3 PF00130//PF13606//PF07649//PF00628//PF15182//PF01300//PF01096//PF02150//PF15898//PF00023//PF13939 Phorbol esters/diacylglycerol binding domain (C1 domain)//Ankyrin repeat//C1-like domain//PHD-finger//Otospiralin//Telomere recombination//Transcription factor S-II (TFIIS)//RNA polymerases M/15 Kd subunit//cGMP-dependent protein kinase interacting domain//Ankyrin repeat//Toxin TisB, type I toxin-antitoxin system GO:0006206//GO:0009432//GO:0006820//GO:0006351//GO:0006144//GO:0035556//GO:0055114//GO:0022611//GO:0007605 pyrimidine nucleobase metabolic process//SOS response//anion transport//transcription, DNA-templated//purine nucleobase metabolic process//intracellular signal transduction//oxidation-reduction process//dormancy process//sensory perception of sound GO:0003676//GO:0003677//GO:0005515//GO:0008270//GO:0005253//GO:0019901//GO:0003725//GO:0047134//GO:0003899 nucleic acid binding//DNA binding//protein binding//zinc ion binding//anion channel activity//protein kinase binding//double-stranded RNA binding//protein-disulfide reductase activity//DNA-directed RNA polymerase activity GO:0005730//GO:0005887 nucleolus//integral component of plasma membrane KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.29574 BP_3 388.67 15.54 1497 91083613 XP_969708.1 722 1.8e-73 PREDICTED: calmodulin [Tribolium castaneum]>gi|270007842|gb|EFA04290.1| hypothetical protein TcasGA2_TC014581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T0E8 267 4.4e-22 Calmodulin-like protein 4 OS=Bos taurus GN=CALML4 PE=2 SV=1 PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.29576 BP_3 388.14 2.00 9624 642911194 XP_008199555.1 11323 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X2 [Tribolium castaneum] 805816096 XM_012293285.1 501 0 PREDICTED: Megachile rotundata inositol 1,4,5-trisphosphate receptor (LOC100879087), transcript variant X4, mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 8649 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF00520//PF01365//PF02815 Ion transport protein//RIH domain//MIR domain GO:0070588//GO:0006811//GO:0006816//GO:0055085 calcium ion transmembrane transport//ion transport//calcium ion transport//transmembrane transport GO:0005216//GO:0005262 ion channel activity//calcium channel activity GO:0016020 membrane KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.29577 BP_3 597.78 5.20 5831 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29579 BP_3 77.00 1.67 2518 642918788 XP_008191584.1 2363 1.6e-263 PREDICTED: uncharacterized protein LOC660407 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O61366 230 1.4e-17 Serine-enriched protein OS=Drosophila melanogaster GN=gprs PE=3 SV=3 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.29580 BP_3 152521.72 12186.12 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29583 BP_3 324.99 2.08 7831 546684330 ERL94035.1 2717 4.5e-304 hypothetical protein D910_11318 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R189 532 4.3e-52 Protein unc-13 homolog D OS=Rattus norvegicus GN=Unc13d PE=2 SV=1 PF00168//PF01688//PF08392 C2 domain//Alphaherpesvirus glycoprotein I//FAE1/Type III polyketide synthase-like protein GO:0006633 fatty acid biosynthetic process GO:0016747//GO:0005515 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding GO:0043657//GO:0016020 host cell//membrane KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.29587 BP_3 1173.44 6.16 9470 546684330 ERL94035.1 3979 0.0e+00 hypothetical protein D910_11318 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O94812 756 5.5e-78 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF02947//PF00168//PF08392//PF01688 flt3 ligand//C2 domain//FAE1/Type III polyketide synthase-like protein//Alphaherpesvirus glycoprotein I GO:0007165//GO:0006633 signal transduction//fatty acid biosynthetic process GO:0005125//GO:0016747//GO:0005515 cytokine activity//transferase activity, transferring acyl groups other than amino-acyl groups//protein binding GO:0016020//GO:0043657 membrane//host cell KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.29591 BP_3 17.33 1.10 1050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29592 BP_3 7.43 0.90 688 741829858 AJA91073.1 505 1.2e-48 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 407 1.2e-38 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.29594 BP_3 165.76 2.80 3145 91088147 XP_971356.1 1233 2.2e-132 PREDICTED: platelet-activating factor acetylhydrolase [Tribolium castaneum]>gi|270012120|gb|EFA08568.1| hypothetical protein TcasGA2_TC006223 [Tribolium castaneum] -- -- -- -- -- K05961 dnk deoxynucleoside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05961 P70683 551 1.1e-54 Platelet-activating factor acetylhydrolase OS=Cavia porcellus GN=PLA2G7 PE=2 SV=1 PF03403//PF00005//PF01121//PF02367 Platelet-activating factor acetylhydrolase, isoform II//ABC transporter//Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0015940//GO:0015937//GO:0046486//GO:0002949//GO:0016042 pantothenate biosynthetic process//coenzyme A biosynthetic process//glycerolipid metabolic process//tRNA threonylcarbamoyladenosine modification//lipid catabolic process GO:0005524//GO:0003847//GO:0004140//GO:0016887 ATP binding//1-alkyl-2-acetylglycerophosphocholine esterase activity//dephospho-CoA kinase activity//ATPase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4235 Mitochondrial thymidine kinase 2/deoxyguanosine kinase Cluster-8309.29595 BP_3 159.10 1.19 6738 270012147 EFA08595.1 7412 0.0e+00 hypothetical protein TcasGA2_TC006253 [Tribolium castaneum] 665401438 NM_166190.4 299 1.87886e-152 Drosophila melanogaster unc-104 ortholog (unc-104), transcript variant C, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5457 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF00959//PF00498//PF00225//PF05014//PF05171//PF10390//PF07353 Phage lysozyme//FHA domain//Kinesin motor domain//Nucleoside 2-deoxyribosyltransferase//Haemin-degrading HemS.ChuX domain//RNA polymerase II elongation factor ELL//Uroplakin II GO:0006206//GO:0006368//GO:0016998//GO:0007017//GO:0061024//GO:0005975//GO:0006826//GO:0007018//GO:0009159//GO:0009253 pyrimidine nucleobase metabolic process//transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process//microtubule-based process//membrane organization//carbohydrate metabolic process//iron ion transport//microtubule-based movement//deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process GO:0008017//GO:0003777//GO:0005515//GO:0003796//GO:0070694//GO:0005524//GO:0050144 microtubule binding//microtubule motor activity//protein binding//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//ATP binding//nucleoside deoxyribosyltransferase activity GO:0030176//GO:0008023//GO:0005874//GO:0045298 integral component of endoplasmic reticulum membrane//transcription elongation factor complex//microtubule//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.29596 BP_3 24.30 1.36 1155 332375791 AEE63036.1 260 5.3e-20 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 156 2.5e-09 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.29598 BP_3 25.40 1.10 1403 270002027 EEZ98474.1 424 6.2e-39 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02176 TRAF-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.29599 BP_3 48.28 0.52 4764 478254095 ENN74383.1 3675 0.0e+00 hypothetical protein YQE_09040, partial [Dendroctonus ponderosae] -- -- -- -- -- K02332 POLG1 DNA polymerase gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02332 Q27607 2892 0.0e+00 DNA polymerase subunit gamma-1, mitochondrial OS=Drosophila melanogaster GN=tam PE=1 SV=2 PF01176//PF07834//PF01300//PF00476//PF01612 Translation initiation factor 1A / IF-1//RanGAP1 C-terminal domain//Telomere recombination//DNA polymerase family A//3'-5' exonuclease GO:0007165//GO:0006446//GO:0006139//GO:0006413//GO:0006260 signal transduction//regulation of translational initiation//nucleobase-containing compound metabolic process//translational initiation//DNA replication GO:0003677//GO:0005096//GO:0003743//GO:0003723//GO:0003887//GO:0008408//GO:0003676//GO:0003725 DNA binding//GTPase activator activity//translation initiation factor activity//RNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//nucleic acid binding//double-stranded RNA binding GO:0042575//GO:0005840 DNA polymerase complex//ribosome KOG3657 Mitochondrial DNA polymerase gamma, catalytic subunit Cluster-8309.296 BP_3 9.00 2.28 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29601 BP_3 688.76 6.86 5131 546675851 ERL86956.1 1551 4.7e-169 hypothetical protein D910_04359 [Dendroctonus ponderosae] 676491074 XM_009067230.1 96 1.00488e-39 Lottia gigantea hypothetical protein mRNA K12179 COPS6, CSN6 COP9 signalosome complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12179 Q9VCY3 1146 1.8e-123 COP9 signalosome complex subunit 6 OS=Drosophila melanogaster GN=CSN6 PE=1 SV=1 PF00848//PF01398//PF05028 Ring hydroxylating alpha subunit (catalytic domain)//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Poly (ADP-ribose) glycohydrolase (PARG) GO:0019439//GO:0055114//GO:0005975 aromatic compound catabolic process//oxidation-reduction process//carbohydrate metabolic process GO:0005515//GO:0051537//GO:0005506//GO:0004649//GO:0016708 protein binding//2 iron, 2 sulfur cluster binding//iron ion binding//poly(ADP-ribose) glycohydrolase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor -- -- KOG3050 COP9 signalosome, subunit CSN6 Cluster-8309.29602 BP_3 25.88 0.39 3531 91078836 XP_971451.1 1905 2.9e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 1.86307e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.4e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01120//PF01546 Alpha-L-fucosidase//Peptidase family M20/M25/M40 GO:0005975//GO:0006508//GO:0008152 carbohydrate metabolic process//proteolysis//metabolic process GO:0016805//GO:0008237//GO:0034701//GO:0004560//GO:0016787 dipeptidase activity//metallopeptidase activity//tripeptidase activity//alpha-L-fucosidase activity//hydrolase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.29604 BP_3 196.03 4.80 2261 642923289 XP_008193692.1 459 8.8e-43 PREDICTED: uncharacterized protein LOC103313098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.29605 BP_3 66.00 3.96 1095 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29606 BP_3 113.60 1.43 4124 642921841 XP_008199342.1 4742 0.0e+00 PREDICTED: adenylate cyclase type 6 [Tribolium castaneum] 195135626 XM_002012198.1 231 7.25092e-115 Drosophila mojavensis GI16861 (Dmoj\GI16861), mRNA K08045 ADCY5 adenylate cyclase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08045 P40144 2163 1.7e-241 Adenylate cyclase type 5 OS=Oryctolagus cuniculus GN=ADCY5 PE=1 SV=1 PF00211//PF07086//PF06327//PF07701 Adenylate and Guanylate cyclase catalytic domain//Jagunal, ER re-organisation during oogenesis//Domain of Unknown Function (DUF1053)//Heme NO binding associated GO:0009190//GO:0035556//GO:0006171//GO:0007029//GO:0006144//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//cAMP biosynthetic process//endoplasmic reticulum organization//purine nucleobase metabolic process//GTP metabolic process//cGMP biosynthetic process GO:0016849//GO:0004016//GO:0004383 phosphorus-oxygen lyase activity//adenylate cyclase activity//guanylate cyclase activity GO:0005886//GO:0005789 plasma membrane//endoplasmic reticulum membrane KOG3619 Adenylate/guanylate cyclase Cluster-8309.29609 BP_3 5.00 1.77 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2961 BP_3 153.35 3.21 2591 189239830 XP_001813387.1 1116 6.6e-119 PREDICTED: Meckel syndrome type 1 protein [Tribolium castaneum]>gi|270011929|gb|EFA08377.1| hypothetical protein TcasGA2_TC006020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXB0 512 3.0e-50 Meckel syndrome type 1 protein OS=Homo sapiens GN=MKS1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29611 BP_3 145.00 11.60 894 91086395 XP_974833.1 474 6.3e-45 PREDICTED: THAP domain-containing protein 4 [Tribolium castaneum]>gi|270009830|gb|EFA06278.1| hypothetical protein TcasGA2_TC009144 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q642B6 320 1.9e-28 THAP domain-containing protein 4 OS=Rattus norvegicus GN=Thap4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29612 BP_3 306.11 21.75 970 766935896 XP_011500333.1 177 1.9e-10 PREDICTED: THAP domain-containing protein 1 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02344//PF10186//PF05485//PF14817 Myc leucine zipper domain//Vacuolar sorting 38 and autophagy-related subunit 14//THAP domain//HAUS augmin-like complex subunit 5 GO:0010508//GO:0006355//GO:0051225 positive regulation of autophagy//regulation of transcription, DNA-templated//spindle assembly GO:0003700//GO:0003676 transcription factor activity, sequence-specific DNA binding//nucleic acid binding GO:0070652//GO:0005667//GO:0005634 HAUS complex//transcription factor complex//nucleus -- -- Cluster-8309.29614 BP_3 58.89 1.40 2324 91076316 XP_969753.1 1330 9.0e-144 PREDICTED: xylulose kinase [Tribolium castaneum]>gi|270002483|gb|EEZ98930.1| hypothetical protein TcasGA2_TC004550 [Tribolium castaneum] -- -- -- -- -- K00854 xylB, XYLB xylulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00854 O75191 1006 1.4e-107 Xylulose kinase OS=Homo sapiens GN=XYLB PE=1 SV=3 PF02782//PF08114//PF00370 FGGY family of carbohydrate kinases, C-terminal domain//ATPase proteolipid family//FGGY family of carbohydrate kinases, N-terminal domain GO:0005975//GO:0050790 carbohydrate metabolic process//regulation of catalytic activity GO:0016773//GO:0030234 phosphotransferase activity, alcohol group as acceptor//enzyme regulator activity -- -- KOG2531 Sugar (pentulose and hexulose) kinases Cluster-8309.29616 BP_3 76.83 3.16 1462 607361803 EZA56073.1 149 5.0e-07 hypothetical protein X777_03918 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.29617 BP_3 342.32 6.32 2903 270001368 EEZ97815.1 2124 9.6e-236 hypothetical protein TcasGA2_TC000182 [Tribolium castaneum] 170046948 XM_001850953.1 142 1.51753e-65 Culex quinquefasciatus tyrosine phosphatase n9, mRNA K18038 PTPN9, MEG2 tyrosine-protein phosphatase non-receptor type 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18038 Q641Z2 948 9.2e-101 Tyrosine-protein phosphatase non-receptor type 9 OS=Rattus norvegicus GN=Ptpn9 PE=2 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.2962 BP_3 505.00 11.97 2326 642933875 XP_008197548.1 1327 2.0e-143 PREDICTED: phospholipase A1 member A-like [Tribolium castaneum]>gi|270013537|gb|EFA09985.1| hypothetical protein TcasGA2_TC012150 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02157 208 4.7e-15 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 PF01058//PF04434 NADH ubiquinone oxidoreductase, 20 Kd subunit//SWIM zinc finger GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process GO:0051536//GO:0008270//GO:0016787 iron-sulfur cluster binding//zinc ion binding//hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.29620 BP_3 175.00 5.75 1759 642911670 XP_008200694.1 402 2.8e-36 PREDICTED: chondroitin sulfate proteoglycan 4 isoform X2 [Tribolium castaneum]>gi|642911672|ref|XP_008200695.1| PREDICTED: chondroitin sulfate proteoglycan 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29621 BP_3 353.48 6.74 2818 642934752 XP_008197796.1 1204 4.5e-129 PREDICTED: transmembrane protein 129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IJ33 690 7.4e-71 E3 ubiquitin-protein ligase TM129 OS=Xenopus tropicalis GN=tmem129 PE=2 SV=1 PF00181//PF05203 Ribosomal Proteins L2, RNA binding domain//Hom_end-associated Hint GO:0006412//GO:0030908//GO:0042254 translation//protein splicing//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.29622 BP_3 1386.67 140.33 768 478250587 ENN71079.1 424 3.4e-39 hypothetical protein YQE_12013, partial [Dendroctonus ponderosae]>gi|546672941|gb|ERL84649.1| hypothetical protein D910_02077 [Dendroctonus ponderosae] -- -- -- -- -- K03676 grxC, GLRX, GLRX2 glutaredoxin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03676 Q8LFQ6 270 1.0e-22 Glutaredoxin-C4 OS=Arabidopsis thaliana GN=GRXC4 PE=2 SV=2 PF00462//PF00085//PF01323 Glutaredoxin//Thioredoxin//DSBA-like thioredoxin domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG1752 Glutaredoxin and related proteins Cluster-8309.29624 BP_3 32.89 0.63 2815 270003257 EEZ99704.1 685 6.8e-69 hypothetical protein TcasGA2_TC002465 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q60HE9 463 1.5e-44 Lysosomal alpha-mannosidase OS=Macaca fascicularis GN=MAN2B1 PE=2 SV=1 PF07748 Glycosyl hydrolases family 38 C-terminal domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0015923 mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.29625 BP_3 15.00 0.31 2590 642921119 XP_975344.2 2219 8.3e-247 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum]>gi|270006197|gb|EFA02645.1| hypothetical protein TcasGA2_TC008366 [Tribolium castaneum] -- -- -- -- -- K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 Q0VD19 1161 1.6e-125 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.29628 BP_3 14.19 1.37 790 478256190 ENN76386.1 402 1.2e-36 hypothetical protein YQE_07108, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2963 BP_3 10.00 0.73 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29632 BP_3 105.48 1.76 3178 642934019 XP_008197606.1 669 5.5e-67 PREDICTED: PCTP-like protein isoform X1 [Tribolium castaneum] 642934018 XM_008199384.1 149 2.13618e-69 PREDICTED: Tribolium castaneum phosphatidylcholine transfer protein (LOC662808), transcript variant X1, mRNA -- -- -- -- Q9Y365 309 1.3e-26 PCTP-like protein OS=Homo sapiens GN=STARD10 PE=1 SV=2 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.29634 BP_3 13.83 0.51 1588 642919443 XP_974536.2 934 5.1e-98 PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum]>gi|642919445|ref|XP_008191871.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum] 158299880 XM_319893.4 229 3.56438e-114 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 800 7.3e-84 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF08168//PF06221//PF00270 NUC205 domain//Putative zinc finger motif, C2HC5-type//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0008270//GO:0003676 ATP binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.29636 BP_3 63.34 1.06 3166 91093871 XP_967859.1 694 6.9e-70 PREDICTED: OTU domain-containing protein 5-A [Tribolium castaneum]>gi|270014527|gb|EFA10975.1| hypothetical protein TcasGA2_TC004141 [Tribolium castaneum] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q7ZX21 197 1.2e-13 OTU domain-containing protein 5-A OS=Xenopus laevis GN=otud5-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.29639 BP_3 446.79 9.27 2614 189233731 XP_971025.2 2325 4.3e-259 PREDICTED: kinesin-like protein KIF3A [Tribolium castaneum]>gi|270015046|gb|EFA11494.1| hypothetical protein TcasGA2_TC014207 [Tribolium castaneum] -- -- -- -- -- K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q9Y496 1393 2.1e-152 Kinesin-like protein KIF3A OS=Homo sapiens GN=KIF3A PE=1 SV=4 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0005875//GO:0005874//GO:0045298 microtubule associated complex//microtubule//tubulin complex KOG4280 Kinesin-like protein Cluster-8309.2964 BP_3 699.74 19.34 2036 642928441 XP_008193786.1 225 1.1e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29641 BP_3 220.00 4.97 2425 270001693 EEZ98140.1 1845 1.8e-203 hypothetical protein TcasGA2_TC000565 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLI3 832 2.2e-87 Membrane metallo-endopeptidase-like 1 OS=Mus musculus GN=Mmel1 PE=1 SV=1 PF01431//PF00233//PF05649 Peptidase family M13//3'5'-cyclic nucleotide phosphodiesterase//Peptidase family M13 GO:0006144//GO:0007165//GO:0006508 purine nucleobase metabolic process//signal transduction//proteolysis GO:0004114//GO:0004222 3',5'-cyclic-nucleotide phosphodiesterase activity//metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.29644 BP_3 182.37 1.46 6312 546678980 ERL89513.1 1263 1.4e-135 hypothetical protein D910_06879 [Dendroctonus ponderosae] 850318596 XM_013007893.1 39 6.00581e-08 PREDICTED: Echinops telfairi L-lactate dehydrogenase A chain-like (LOC101645051), mRNA K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 1195 4.6e-129 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF03721//PF00056//PF02866//PF02737 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//lactate/malate dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0006631//GO:0006568//GO:0006554//GO:0006552//GO:0055114//GO:0006550//GO:0006574//GO:0006633//GO:0018874 fatty acid metabolic process//tryptophan metabolic process//lysine catabolic process//leucine catabolic process//oxidation-reduction process//isoleucine catabolic process//valine catabolic process//fatty acid biosynthetic process//benzoate metabolic process GO:0003857//GO:0016491//GO:0016616//GO:0051287 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1495 Lactate dehydrogenase Cluster-8309.29645 BP_3 5.27 0.40 923 646713645 KDR17927.1 356 3.1e-31 hypothetical protein L798_08003 [Zootermopsis nevadensis] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 145 3.8e-08 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29646 BP_3 16.38 0.63 1550 91092160 XP_967690.1 701 5.2e-71 PREDICTED: RNA-binding protein 24-B [Tribolium castaneum]>gi|270014448|gb|EFA10896.1| hypothetical protein TcasGA2_TC001720 [Tribolium castaneum] 462310806 APGK01047199.1 66 1.42045e-23 Dendroctonus ponderosae Seq01047209, whole genome shotgun sequence -- -- -- -- Q9I8B3 420 8.2e-40 RNA-binding protein 24-B OS=Xenopus laevis GN=rbm24-b PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily) Cluster-8309.29647 BP_3 99.00 7.49 929 91093429 XP_968933.1 257 9.5e-20 PREDICTED: uncharacterized protein LOC657376 [Tribolium castaneum]>gi|270015461|gb|EFA11909.1| hypothetical protein TcasGA2_TC004066 [Tribolium castaneum] -- -- -- -- -- K18157 TMEM126A transmembrane protein 126A http://www.genome.jp/dbget-bin/www_bget?ko:K18157 -- -- -- -- PF03554 UL73 viral envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.29648 BP_3 158.32 2.39 3482 91092160 XP_967690.1 781 6.2e-80 PREDICTED: RNA-binding protein 24-B [Tribolium castaneum]>gi|270014448|gb|EFA10896.1| hypothetical protein TcasGA2_TC001720 [Tribolium castaneum] 645005484 XM_001606127.3 58 9.04415e-19 PREDICTED: Nasonia vitripennis RNA-binding protein 24-A-like (LOC100122565), transcript variant X3, mRNA -- -- -- -- Q9I8B3 420 1.8e-39 RNA-binding protein 24-B OS=Xenopus laevis GN=rbm24-b PE=2 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily) Cluster-8309.29649 BP_3 122.87 2.29 2881 478258529 ENN78604.1 491 2.2e-46 hypothetical protein YQE_04971, partial [Dendroctonus ponderosae] -- -- -- -- -- K10694 ZNRF1_2 E3 ubiquitin-protein ligase ZNRF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10694 F7EP40 390 4.6e-36 E3 ubiquitin-protein ligase znrf1 OS=Xenopus tropicalis GN=znrf1 PE=3 SV=1 PF00097//PF12678//PF08120//PF17123//PF12906//PF14634//PF13639//PF15926//PF01612 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//Tamulustoxin family//RING-like zinc finger//RING-variant domain//zinc-RING finger domain//Ring finger domain//E3 ubiquitin-protein ligase RNF220//3'-5' exonuclease GO:0006810//GO:0016567//GO:0006139//GO:0090263//GO:0009405 transport//protein ubiquitination//nucleobase-containing compound metabolic process//positive regulation of canonical Wnt signaling pathway//pathogenesis GO:0005515//GO:0019870//GO:0046872//GO:0008408//GO:0003676//GO:0008270 protein binding//potassium channel inhibitor activity//metal ion binding//3'-5' exonuclease activity//nucleic acid binding//zinc ion binding GO:0005576 extracellular region KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.2965 BP_3 13.00 1.08 872 861641274 KMQ93498.1 160 1.6e-08 peroxidase 12 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29651 BP_3 213.36 1.91 5688 189242051 XP_968641.2 3234 0.0e+00 PREDICTED: DNA replication licensing factor Mcm3 [Tribolium castaneum]>gi|270015933|gb|EFA12381.1| hypothetical protein TcasGA2_TC002088 [Tribolium castaneum] 752884597 XM_011261744.1 285 9.60837e-145 PREDICTED: Camponotus floridanus DNA replication licensing factor Mcm3 (LOC105253613), transcript variant X2, mRNA K02541 MCM3 DNA replication licensing factor MCM3 http://www.genome.jp/dbget-bin/www_bget?ko:K02541 Q9XYU1 2771 7.3e-312 DNA replication licensing factor Mcm3 OS=Drosophila melanogaster GN=Mcm3 PE=1 SV=1 PF00493//PF07726//PF07728 MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily) GO:0006260//GO:0006270 DNA replication//DNA replication initiation GO:0003677//GO:0016887//GO:0005524//GO:0017111 DNA binding//ATPase activity//ATP binding//nucleoside-triphosphatase activity GO:0005634 nucleus KOG0479 DNA replication licensing factor, MCM3 component Cluster-8309.29652 BP_3 36.45 1.64 1361 642931818 XP_008196746.1 1472 1.8e-160 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q5RA96 1114 2.4e-120 GMP synthase [glutamine-hydrolyzing] OS=Pongo abelii GN=GMPS PE=2 SV=1 PF00958 GMP synthase C terminal domain GO:0006536//GO:0006144//GO:0006164//GO:0006177 glutamate metabolic process//purine nucleobase metabolic process//purine nucleotide biosynthetic process//GMP biosynthetic process GO:0003922//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//ATP binding -- -- KOG1622 GMP synthase Cluster-8309.29653 BP_3 977.01 8.39 5904 189233727 XP_970593.2 2892 0.0e+00 PREDICTED: AP-3 complex subunit beta-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12397 AP3B AP-3 complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12397 Q13367 2115 8.9e-236 AP-3 complex subunit beta-2 OS=Homo sapiens GN=AP3B2 PE=1 SV=2 PF13181//PF08492//PF13174//PF01602//PF02985//PF02535//PF00330//PF13371//PF13374//PF00515//PF09726//PF02862//PF13414//PF02486 Tetratricopeptide repeat//SRP72 RNA-binding domain//Tetratricopeptide repeat//Adaptin N terminal region//HEAT repeat//ZIP Zinc transporter//Aconitase family (aconitate hydratase)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Transmembrane protein//DDHD domain//TPR repeat//Replication initiation factor GO:0030001//GO:0008152//GO:0006265//GO:0055085//GO:0006614//GO:0006270//GO:0016192//GO:0006886 metal ion transport//metabolic process//DNA topological change//transmembrane transport//SRP-dependent cotranslational protein targeting to membrane//DNA replication initiation//vesicle-mediated transport//intracellular protein transport GO:0046873//GO:0008312//GO:0046872//GO:0003677//GO:0005515//GO:0003916 metal ion transmembrane transporter activity//7S RNA binding//metal ion binding//DNA binding//protein binding//DNA topoisomerase activity GO:0016020//GO:0030117//GO:0016021//GO:0048500 membrane//membrane coat//integral component of membrane//signal recognition particle KOG1060 Vesicle coat complex AP-3, beta subunit Cluster-8309.29654 BP_3 202.16 2.89 3659 642912135 XP_008200821.1 3329 0.0e+00 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3-like [Tribolium castaneum] -- -- -- -- -- K08628 ADAMTS14 a disintegrin and metalloproteinase with thrombospondin motifs 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08628 Q8WXS8 1504 3.9e-165 A disintegrin and metalloproteinase with thrombospondin motifs 14 OS=Homo sapiens GN=ADAMTS14 PE=2 SV=2 PF08686//PF01421//PF05372//PF00413 PLAC (protease and lacunin) domain//Reprolysin (M12B) family zinc metalloprotease//Delta lysin family//Matrixin GO:0019836//GO:0006508 hemolysis by symbiont of host erythrocytes//proteolysis GO:0008270//GO:0004222//GO:0008233 zinc ion binding//metalloendopeptidase activity//peptidase activity GO:0031012//GO:0005576 extracellular matrix//extracellular region -- -- Cluster-8309.29657 BP_3 11.73 2.05 567 662207644 XP_008477334.1 178 8.4e-11 PREDICTED: zinc finger protein 721-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 160 4.2e-10 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.29658 BP_3 79.01 0.74 5416 546678611 ERL89193.1 1404 5.5e-152 hypothetical protein D910_06567 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U481 630 1.3e-63 Major facilitator superfamily domain-containing protein 12 OS=Mus musculus GN=Mfsd12 PE=1 SV=1 PF07690//PF00171//PF04827 Major Facilitator Superfamily//Aldehyde dehydrogenase family//Plant transposon protein GO:0008152//GO:0055085//GO:0055114 metabolic process//transmembrane transport//oxidation-reduction process GO:0016788//GO:0016491 hydrolase activity, acting on ester bonds//oxidoreductase activity GO:0016021 integral component of membrane KOG4830 Predicted sugar transporter Cluster-8309.2966 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29661 BP_3 1496.62 10.72 7023 642926249 XP_974073.3 1626 1.3e-177 PREDICTED: mannose-1-phosphate guanyltransferase beta [Tribolium castaneum]>gi|270009027|gb|EFA05475.1| hypothetical protein TcasGA2_TC015659 [Tribolium castaneum] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q295Y7 1534 2.5e-168 Mannose-1-phosphate guanyltransferase beta OS=Drosophila pseudoobscura pseudoobscura GN=GA10892 PE=3 SV=1 PF09270//PF01128//PF02932//PF00483//PF08671//PF06459//PF07959//PF00076 Beta-trefoil DNA-binding domain//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//Neurotransmitter-gated ion-channel transmembrane region//Nucleotidyl transferase//Anti-repressor SinI//Ryanodine Receptor TM 4-6//L-fucokinase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006816//GO:0008299//GO:0006355//GO:0006694//GO:0006874//GO:0009058//GO:0006811 calcium ion transport//isoprenoid biosynthetic process//regulation of transcription, DNA-templated//steroid biosynthetic process//cellular calcium ion homeostasis//biosynthetic process//ion transport GO:0000982//GO:0016772//GO:0000978//GO:0016779//GO:0050518//GO:0046983//GO:0005219//GO:0003676 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//transferase activity, transferring phosphorus-containing groups//RNA polymerase II core promoter proximal region sequence-specific DNA binding//nucleotidyltransferase activity//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//protein dimerization activity//ryanodine-sensitive calcium-release channel activity//nucleic acid binding GO:0016021//GO:0005622//GO:0005634//GO:0016020 integral component of membrane//intracellular//nucleus//membrane KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.29665 BP_3 1015.10 7.97 6428 642928935 XP_008195623.1 3946 0.0e+00 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K17426 MRPL45 large subunit ribosomal protein L45 http://www.genome.jp/dbget-bin/www_bget?ko:K17426 Q9VCX1 1021 7.0e-109 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF00595//PF02188//PF13180//PF07961//PF02196 PDZ domain (Also known as DHR or GLGF)//GoLoco motif//PDZ domain//MBA1-like protein//Raf-like Ras-binding domain GO:0032979//GO:0007165 protein insertion into mitochondrial membrane from inner side//signal transduction GO:0005515//GO:0030695//GO:0005057 protein binding//GTPase regulator activity//receptor signaling protein activity GO:0005743 mitochondrial inner membrane KOG4599 Putative mitochondrial/chloroplast ribosomal protein L45 Cluster-8309.29666 BP_3 57.48 0.41 6989 642928935 XP_008195623.1 2124 2.3e-235 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K17426 MRPL45 large subunit ribosomal protein L45 http://www.genome.jp/dbget-bin/www_bget?ko:K17426 Q9VCX1 1021 7.6e-109 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF00788//PF02196//PF07961//PF13180//PF02188//PF00595 Ras association (RalGDS/AF-6) domain//Raf-like Ras-binding domain//MBA1-like protein//PDZ domain//GoLoco motif//PDZ domain (Also known as DHR or GLGF) GO:0007165//GO:0032979 signal transduction//protein insertion into mitochondrial membrane from inner side GO:0005057//GO:0030695//GO:0005515 receptor signaling protein activity//GTPase regulator activity//protein binding GO:0005743 mitochondrial inner membrane KOG4599 Putative mitochondrial/chloroplast ribosomal protein L45 Cluster-8309.29667 BP_3 250.00 9.31 1586 332373850 AEE62066.1 699 9.1e-71 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13239 PECI peroxisomal 3,2-trans-enoyl-CoA isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K13239 Q5XIC0 481 7.1e-47 Enoyl-CoA delta isomerase 2, mitochondrial OS=Rattus norvegicus GN=Eci2 PE=1 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG0016 Enoyl-CoA hydratase/isomerase Cluster-8309.29668 BP_3 420.79 10.64 2198 478254032 ENN74324.1 1869 2.7e-206 hypothetical protein YQE_09295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29669 BP_3 256.34 11.88 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2967 BP_3 175.81 196.84 325 22901764 AAN10061.1 154 2.9e-08 Kunitz-like protease inhibitor precursor [Ancylostoma caninum] -- -- -- -- -- -- -- -- -- P10280 151 2.7e-09 Kunitz-type proteinase inhibitor 5 II OS=Anemonia sulcata PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.29670 BP_3 56.09 0.57 5007 642913638 XP_008201098.1 2668 1.4e-298 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 4.4e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF01055//PF03539 Glycosyl hydrolases family 31//Spumavirus aspartic protease (A9) GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004553//GO:0004190 hydrolase activity, hydrolyzing O-glycosyl compounds//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.29672 BP_3 93.12 0.89 5326 642932474 XP_008197131.1 1105 2.6e-117 PREDICTED: uncharacterized protein LOC662025 isoform X1 [Tribolium castaneum] 642932473 XM_008198909.1 191 1.61516e-92 PREDICTED: Tribolium castaneum uncharacterized LOC662025 (LOC662025), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29673 BP_3 51.70 0.51 5151 642932474 XP_008197131.1 1105 2.5e-117 PREDICTED: uncharacterized protein LOC662025 isoform X1 [Tribolium castaneum] 642932473 XM_008198909.1 191 1.56173e-92 PREDICTED: Tribolium castaneum uncharacterized LOC662025 (LOC662025), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29674 BP_3 429.22 2.74 7846 642910328 XP_008200285.1 9638 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum]>gi|270014917|gb|EFA11365.1| hypothetical protein TcasGA2_TC011522 [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 2979 0.0e+00 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF08545//PF00108//PF00107//PF02052//PF00975//PF00106 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain//Zinc-binding dehydrogenase//Gallidermin//Thioesterase domain//short chain dehydrogenase GO:0008152//GO:0006633//GO:0009058//GO:0055114//GO:0042742//GO:0042967 metabolic process//fatty acid biosynthetic process//biosynthetic process//oxidation-reduction process//defense response to bacterium//acyl-carrier-protein biosynthetic process GO:0004316//GO:0016747//GO:0004319//GO:0016788//GO:0004320//GO:0016491//GO:0016295//GO:0000166//GO:0008270//GO:0016296//GO:0004314//GO:0004313//GO:0004315//GO:0004317 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity//transferase activity, transferring acyl groups other than amino-acyl groups//enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity//hydrolase activity, acting on ester bonds//oleoyl-[acyl-carrier-protein] hydrolase activity//oxidoreductase activity//myristoyl-[acyl-carrier-protein] hydrolase activity//nucleotide binding//zinc ion binding//palmitoyl-[acyl-carrier-protein] hydrolase activity//[acyl-carrier-protein] S-malonyltransferase activity//[acyl-carrier-protein] S-acetyltransferase activity//3-oxoacyl-[acyl-carrier-protein] synthase activity//3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0005576//GO:0005835 extracellular region//fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.29675 BP_3 98.10 0.76 6539 123407101 XP_001302933.1 225 3.5e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.1e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29677 BP_3 1137.84 10.76 5389 642935919 XP_008198229.1 1824 1.1e-200 PREDICTED: dual specificity protein phosphatase Mpk3 isoform X2 [Tribolium castaneum]>gi|270013985|gb|EFA10433.1| hypothetical protein TcasGA2_TC012676 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9VVW5 864 9.4e-91 Dual specificity protein phosphatase Mpk3 OS=Drosophila melanogaster GN=Mkp3 PE=1 SV=2 PF05706//PF00102//PF04179//PF00782//PF00020 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain//TNFR/NGFR cysteine-rich region GO:0019988//GO:0006570//GO:0006470//GO:0035335 charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation//peptidyl-tyrosine dephosphorylation GO:0004725//GO:0005515//GO:0008138//GO:0017017//GO:0043399//GO:0004721 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//MAP kinase tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity//phosphoprotein phosphatase activity -- -- KOG1717 Dual specificity phosphatase Cluster-8309.29679 BP_3 80.59 0.92 4498 546676381 ERL87403.1 602 4.6e-59 hypothetical protein D910_04798 [Dendroctonus ponderosae] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 359 2.8e-32 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF00155//PF01212 Aminotransferase class I and II//Beta-eliminating lyase GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG1368 Threonine aldolase Cluster-8309.2968 BP_3 2239.88 135.58 1088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29680 BP_3 346.91 8.26 2315 642910317 XP_008200281.1 1312 1.1e-141 PREDICTED: dimethyladenosine transferase 1, mitochondrial [Tribolium castaneum] -- -- -- -- -- K15266 TFB1M dimethyladenosine transferase 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K15266 Q7T0W5 857 2.6e-90 Dimethyladenosine transferase 1, mitochondrial OS=Xenopus laevis GN=tfb1m PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.29683 BP_3 306.23 1.54 9907 478250015 ENN70521.1 4003 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 573901209 XM_006638269.1 121 2.46448e-53 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2864 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF00612//PF06414//PF00063//PF00437//PF06017 IQ calmodulin-binding motif//Zeta toxin//Myosin head (motor domain)//Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding GO:0006810 transport GO:0005515//GO:0005524//GO:0016301//GO:0003774 protein binding//ATP binding//kinase activity//motor activity GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.29684 BP_3 48.00 2.04 1424 270006713 EFA03161.1 906 8.1e-95 hypothetical protein TcasGA2_TC013080 [Tribolium castaneum] -- -- -- -- -- K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 P35428 315 1.1e-27 Transcription factor HES-1 OS=Mus musculus GN=Hes1 PE=1 SV=1 PF07527//PF00010 Hairy Orange//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- KOG4304 Transcriptional repressors of the hairy/E(spl) family (contains HLH) Cluster-8309.29685 BP_3 1089.82 63.04 1125 642937160 XP_969386.2 1065 2.3e-113 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] -- -- -- -- -- K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 Q1RMU3 561 2.7e-56 Prolyl 4-hydroxylase subunit alpha-1 OS=Bos taurus GN=P4HA1 PE=1 SV=1 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0018401//GO:0006525//GO:0006560//GO:0055114 peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process//proline metabolic process//oxidation-reduction process GO:0004656//GO:0016702 procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005783 endoplasmic reticulum KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.29686 BP_3 2070.59 63.84 1855 91084199 XP_967748.1 2385 3.3e-266 PREDICTED: T-complex protein 1 subunit zeta [Tribolium castaneum]>gi|270009362|gb|EFA05810.1| hypothetical protein TcasGA2_TC030760 [Tribolium castaneum] 242013594 XM_002427443.1 191 5.55863e-93 Pediculus humanus corporis T-complex protein 1 subunit zeta, putative, mRNA K09498 CCT6 T-complex protein 1 subunit zeta http://www.genome.jp/dbget-bin/www_bget?ko:K09498 P80317 1984 4.3e-221 T-complex protein 1 subunit zeta OS=Mus musculus GN=Cct6a PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0005737 cytoplasm KOG0359 Chaperonin complex component, TCP-1 zeta subunit (CCT6) Cluster-8309.29687 BP_3 1401.63 29.69 2567 91086165 XP_970259.1 2753 9.8e-309 PREDICTED: ATP-dependent zinc metalloprotease YME1 homolog [Tribolium castaneum]>gi|270009883|gb|EFA06331.1| hypothetical protein TcasGA2_TC009202 [Tribolium castaneum] 759074133 XM_011348443.1 98 3.86167e-41 PREDICTED: Cerapachys biroi ATP-dependent zinc metalloprotease YME1 homolog (LOC105284713), transcript variant X3, mRNA K08955 YME1 ATP-dependent metalloprotease http://www.genome.jp/dbget-bin/www_bget?ko:K08955 P54813 1417 3.4e-155 ATP-dependent zinc metalloprotease YME1 homolog OS=Caenorhabditis elegans GN=ymel-1 PE=3 SV=2 PF00004//PF01434//PF05496//PF00158//PF06068//PF01695//PF07728//PF02562//PF06414//PF02367 ATPase family associated with various cellular activities (AAA)//Peptidase family M41//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006355//GO:0006281//GO:0030163//GO:0002949//GO:0006310//GO:0006508 regulation of transcription, DNA-templated//DNA repair//protein catabolic process//tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis GO:0016301//GO:0016887//GO:0008134//GO:0005524//GO:0004222//GO:0009378//GO:0017111//GO:0003678 kinase activity//ATPase activity//transcription factor binding//ATP binding//metalloendopeptidase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//DNA helicase activity GO:0009379//GO:0016020//GO:0005667//GO:0005657 Holliday junction helicase complex//membrane//transcription factor complex//replication fork KOG0734 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.29690 BP_3 455.67 8.17 2980 478251696 ENN72150.1 1472 4.0e-160 hypothetical protein YQE_11207, partial [Dendroctonus ponderosae]>gi|546680948|gb|ERL91122.1| hypothetical protein D910_08463 [Dendroctonus ponderosae] -- -- -- -- -- K14308 NUP54, NUP57 nuclear pore complex protein Nup54 http://www.genome.jp/dbget-bin/www_bget?ko:K14308 Q8BTS4 726 5.2e-75 Nuclear pore complex protein Nup54 OS=Mus musculus GN=Nup54 PE=1 SV=1 PF00969 Class II histocompatibility antigen, beta domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG3091 Nuclear pore complex, p54 component (sc Nup57) Cluster-8309.29691 BP_3 23.00 0.64 2019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00951 Arterivirus GL envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.29695 BP_3 447.00 15.07 1721 91085067 XP_966737.1 821 7.0e-85 PREDICTED: actin-related protein 2/3 complex subunit 4 [Tribolium castaneum]>gi|270009038|gb|EFA05486.1| hypothetical protein TcasGA2_TC015671 [Tribolium castaneum] 241714781 XM_002413479.1 117 7.04899e-52 Ixodes scapularis conserved hypothetical protein, mRNA K05755 ARPC4 actin related protein 2/3 complex, subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05755 Q148J6 749 6.5e-78 Actin-related protein 2/3 complex subunit 4 OS=Bos taurus GN=ARPC4 PE=1 SV=3 PF04114//PF05856 Gaa1-like, GPI transamidase component//ARP2/3 complex 20 kDa subunit (ARPC4) GO:0030041//GO:0034314 actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0016021//GO:0015629//GO:0005885//GO:0005856//GO:0042765 integral component of membrane//actin cytoskeleton//Arp2/3 protein complex//cytoskeleton//GPI-anchor transamidase complex KOG1876 Actin-related protein Arp2/3 complex, subunit ARPC4 Cluster-8309.29697 BP_3 47.87 1.04 2521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.2970 BP_3 738.51 38.64 1213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29700 BP_3 19.00 1.84 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29701 BP_3 198.41 2.04 4981 642933730 XP_008197339.1 4432 0.0e+00 PREDICTED: transmembrane protein 132B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q14DG7 701 6.9e-72 Transmembrane protein 132B OS=Homo sapiens GN=TMEM132B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4789 Uncharacterized conserved protein Cluster-8309.29702 BP_3 1163.71 36.00 1850 91076404 XP_969308.1 1708 1.1e-187 PREDICTED: protein RMD5 homolog A [Tribolium castaneum]>gi|270002561|gb|EEZ99008.1| hypothetical protein TcasGA2_TC004876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H871 1091 1.5e-117 Protein RMD5 homolog A OS=Homo sapiens GN=RMND5A PE=1 SV=1 PF16740//PF07352//PF07926//PF04977//PF09177//PF10473 Spindle and kinetochore-associated protein 2//Bacteriophage Mu Gam like protein//TPR/MLP1/MLP2-like protein//Septum formation initiator//Syntaxin 6, N-terminal//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0048193//GO:0042262//GO:0007049//GO:0007059//GO:0007067//GO:0006606//GO:0000090//GO:0031110//GO:0051301 Golgi vesicle transport//DNA protection//cell cycle//chromosome segregation//mitotic nuclear division//protein import into nucleus//mitotic anaphase//regulation of microtubule polymerization or depolymerization//cell division GO:0003690//GO:0042803//GO:0008017//GO:0045502//GO:0008134 double-stranded DNA binding//protein homodimerization activity//microtubule binding//dynein binding//transcription factor binding GO:0005667//GO:0030286//GO:0016020//GO:0000940//GO:0045298//GO:0005876 transcription factor complex//dynein complex//membrane//condensed chromosome outer kinetochore//tubulin complex//spindle microtubule KOG2817 Predicted E3 ubiquitin ligase Cluster-8309.29703 BP_3 157.92 3.24 2639 91076500 XP_973094.1 2588 1.4e-289 PREDICTED: alkaline phosphatase-like [Tribolium castaneum] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 Q92058 1041 1.4e-111 Alkaline phosphatase, tissue-nonspecific isozyme OS=Gallus gallus GN=ALPL PE=2 SV=1 PF08170//PF01676//PF00549//PF00245 POPLD (NUC188) domain//Metalloenzyme superfamily//CoA-ligase//Alkaline phosphatase GO:0008152//GO:0051252//GO:0006396//GO:0008033 metabolic process//regulation of RNA metabolic process//RNA processing//tRNA processing GO:0003824//GO:0016791//GO:0004526//GO:0046872 catalytic activity//phosphatase activity//ribonuclease P activity//metal ion binding GO:0030677 ribonuclease P complex -- -- Cluster-8309.29705 BP_3 188.69 1.64 5850 642917952 XP_008198956.1 1655 4.7e-181 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 728 6.0e-75 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.29706 BP_3 336.99 3.16 5429 91082499 XP_972877.1 1497 9.1e-163 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU29 852 2.3e-89 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF04097//PF04121//PF00569//PF02066//PF16276//PF00637//PF06701 Nup93/Nic96//Nuclear pore protein 84 / 107//Zinc finger, ZZ type//Metallothionein family 11//Nucleophosmin C-terminal domain//Region in Clathrin and VPS//Mib_herc2 GO:0016567//GO:0006810//GO:0016192//GO:0006886 protein ubiquitination//transport//vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270//GO:0046872//GO:0005507//GO:0004842 nucleic acid binding//zinc ion binding//metal ion binding//copper ion binding//ubiquitin-protein transferase activity GO:0005643 nuclear pore -- -- Cluster-8309.29709 BP_3 342.00 12.98 1562 91076846 XP_974788.1 2012 5.0e-223 PREDICTED: DDB1- and CUL4-associated factor 13 [Tribolium castaneum]>gi|270001818|gb|EEZ98265.1| hypothetical protein TcasGA2_TC000707 [Tribolium castaneum] -- -- -- -- -- K11806 WDSOF1 WD repeat and SOF domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11806 Q5ZLK1 1550 7.7e-171 DDB1- and CUL4-associated factor 13 OS=Gallus gallus GN=DCAF13 PE=2 SV=1 PF00400//PF08023//PF04053 WD domain, G-beta repeat//Frog antimicrobial peptide//Coatomer WD associated region GO:0006886//GO:0016192//GO:0006952 intracellular protein transport//vesicle-mediated transport//defense response GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0005576//GO:0030117 extracellular region//membrane coat KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats) Cluster-8309.2971 BP_3 41.00 6.58 592 642910810 XP_008193419.1 163 4.8e-09 PREDICTED: uncharacterized protein LOC103313033 [Tribolium castaneum]>gi|270014982|gb|EFA11430.1| hypothetical protein TcasGA2_TC013608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29710 BP_3 983.98 9.51 5278 91082499 XP_972877.1 1497 8.9e-163 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU29 852 2.3e-89 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF00637//PF06701//PF16276//PF02066//PF04121//PF00569//PF04097 Region in Clathrin and VPS//Mib_herc2//Nucleophosmin C-terminal domain//Metallothionein family 11//Nuclear pore protein 84 / 107//Zinc finger, ZZ type//Nup93/Nic96 GO:0016567//GO:0006810//GO:0016192//GO:0006886 protein ubiquitination//transport//vesicle-mediated transport//intracellular protein transport GO:0004842//GO:0005507//GO:0046872//GO:0003676//GO:0008270 ubiquitin-protein transferase activity//copper ion binding//metal ion binding//nucleic acid binding//zinc ion binding GO:0005643 nuclear pore -- -- Cluster-8309.29714 BP_3 7.00 1.13 591 91081147 XP_975562.1 188 6.1e-12 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270006377|gb|EFA02825.1| cytochrome P450 6BQ12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4U9 129 1.7e-06 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0016705//GO:0009055//GO:0005506//GO:0004497//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity//iron ion binding//monooxygenase activity//heme binding -- -- -- -- Cluster-8309.29716 BP_3 3489.84 92.92 2102 189234482 XP_970034.2 1101 2.9e-117 PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|270001732|gb|EEZ98179.1| hypothetical protein TcasGA2_TC000608 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q8UWA5 340 2.1e-30 Carbonic anhydrase 2 OS=Tribolodon hakonensis GN=ca2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29718 BP_3 644.68 4.13 7814 642929402 XP_008195823.1 7372 0.0e+00 PREDICTED: unconventional myosin-Va isoform X2 [Tribolium castaneum] 766917087 XM_011503499.1 99 3.29574e-41 PREDICTED: Ceratosolen solmsi marchali unconventional myosin-Va (LOC105365325), mRNA K10357 MYO5 myosin V http://www.genome.jp/dbget-bin/www_bget?ko:K10357 Q9QYF3 4233 0.0e+00 Unconventional myosin-Va OS=Rattus norvegicus GN=Myo5a PE=1 SV=1 PF05902//PF01890//PF00612//PF11857//PF08437//PF00063 4.1 protein C-terminal domain (CTD)//Cobalamin synthesis G C-terminus//IQ calmodulin-binding motif//Domain of unknown function (DUF3377)//Glycosyl transferase family 8 C-terminal//Myosin head (motor domain) GO:0009103//GO:0009236 lipopolysaccharide biosynthetic process//cobalamin biosynthetic process GO:0005524//GO:0004222//GO:0005198//GO:0005515//GO:0003779//GO:0003774//GO:0008918 ATP binding//metalloendopeptidase activity//structural molecule activity//protein binding//actin binding//motor activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG0160 Myosin class V heavy chain Cluster-8309.29719 BP_3 3.00 0.88 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29725 BP_3 94.16 1.27 3853 91083301 XP_974629.1 1378 4.1e-149 PREDICTED: alpha-methylacyl-CoA racemase [Tribolium castaneum]>gi|270007738|gb|EFA04186.1| hypothetical protein TcasGA2_TC014435 [Tribolium castaneum] -- -- -- -- -- K01796 E5.1.99.4, AMACR, mcr alpha-methylacyl-CoA racemase http://www.genome.jp/dbget-bin/www_bget?ko:K01796 O09174 1099 3.8e-118 Alpha-methylacyl-CoA racemase OS=Mus musculus GN=Amacr PE=1 SV=4 PF00536//PF04178//PF07647//PF02515 SAM domain (Sterile alpha motif)//Got1/Sft2-like family//SAM domain (Sterile alpha motif)//CoA-transferase family III GO:0008152//GO:0016192 metabolic process//vesicle-mediated transport GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.29726 BP_3 45.89 3.78 877 237820629 NP_001153782.1 889 4.7e-93 transmembrane protein 120B [Tribolium castaneum]>gi|270004540|gb|EFA00988.1| hypothetical protein TcasGA2_TC003901 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9U1M2 770 1.2e-80 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851//PF16326 TMPIT-like protein//ABC transporter C-terminal domain -- -- GO:0003677 DNA binding GO:0016021 integral component of membrane KOG4758 Predicted membrane protein Cluster-8309.29727 BP_3 34.53 1.79 1221 91076494 XP_972946.1 372 5.8e-33 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 277 2.5e-23 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29728 BP_3 19.97 0.89 1375 91076494 XP_972946.1 541 1.7e-52 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 394 7.6e-37 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2973 BP_3 9062.00 2075.53 502 642915881 XP_008196364.1 178 7.5e-11 PREDICTED: cuticle protein 65-like [Tribolium castaneum]>gi|270004064|gb|EFA00512.1| hypothetical protein TcasGA2_TC003376 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29730 BP_3 50.88 0.99 2770 91076494 XP_972946.1 289 5.5e-23 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 221 1.8e-16 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29731 BP_3 1657.00 21.81 3953 642921132 XP_008192700.1 4757 0.0e+00 PREDICTED: leucine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270006203|gb|EFA02651.1| hypothetical protein TcasGA2_TC008372 [Tribolium castaneum] 684411112 XM_009178024.1 39 3.75014e-08 Opisthorchis viverrini hypothetical protein partial mRNA K01869 LARS, leuS leucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01869 Q9P2J5 3732 0.0e+00 Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=LARS PE=1 SV=2 PF08264//PF00133//PF09334 Anticodon-binding domain of tRNA//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0009098//GO:0009097//GO:0006418//GO:0006429//GO:0006450//GO:0009099 leucine biosynthetic process//isoleucine biosynthetic process//tRNA aminoacylation for protein translation//leucyl-tRNA aminoacylation//regulation of translational fidelity//valine biosynthetic process GO:0005524//GO:0004823//GO:0000166//GO:0004812//GO:0002161 ATP binding//leucine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity GO:0005737 cytoplasm KOG0437 Leucyl-tRNA synthetase Cluster-8309.29732 BP_3 13.05 0.32 2279 642927675 XP_008195360.1 1255 4.4e-135 PREDICTED: NAD kinase 2, mitochondrial, partial [Tribolium castaneum] -- -- -- -- -- K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 Q1HCL7 635 1.4e-64 NAD kinase 2, mitochondrial OS=Rattus norvegicus GN=Nadk2 PE=2 SV=1 PF03575//PF01513//PF00781 Peptidase family S51//ATP-NAD kinase//Diacylglycerol kinase catalytic domain GO:0008152//GO:0046497//GO:0006741//GO:0006508//GO:0006769 metabolic process//nicotinate nucleotide metabolic process//NADP biosynthetic process//proteolysis//nicotinamide metabolic process GO:0003951//GO:0016301//GO:0008236 NAD+ kinase activity//kinase activity//serine-type peptidase activity -- -- KOG4180 Predicted kinase Cluster-8309.29733 BP_3 456.99 25.81 1145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29734 BP_3 74.09 1.24 3172 478257125 ENN77288.1 488 5.3e-46 hypothetical protein YQE_06114, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0P5B9 244 4.3e-19 Ankyrin repeat domain-containing protein 39 OS=Bos taurus GN=ANKRD39 PE=2 SV=1 PF06399//PF13606//PF00023 GTP cyclohydrolase I feedback regulatory protein (GFRP)//Ankyrin repeat//Ankyrin repeat GO:0009890 negative regulation of biosynthetic process GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.29735 BP_3 128.25 0.64 10014 478255038 ENN75270.1 2558 1.6e-285 hypothetical protein YQE_08186, partial [Dendroctonus ponderosae]>gi|546673325|gb|ERL84953.1| hypothetical protein D910_02376 [Dendroctonus ponderosae] -- -- -- -- -- K14301 NUP107, NUP84 nuclear pore complex protein Nup107 http://www.genome.jp/dbget-bin/www_bget?ko:K14301 Q8BH74 1282 5.9e-139 Nuclear pore complex protein Nup107 OS=Mus musculus GN=Nup107 PE=2 SV=1 PF04121 Nuclear pore protein 84 / 107 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1964 Nuclear pore complex, rNup107 component (sc Nup84) Cluster-8309.29736 BP_3 799.00 112.51 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29737 BP_3 121.00 71.73 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29738 BP_3 31.85 1.77 1161 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2974 BP_3 66.23 2.22 1732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29740 BP_3 1207.13 20.24 3166 270012489 EFA08937.1 358 6.3e-31 hypothetical protein TcasGA2_TC006644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JMD0 137 1.1e-06 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Mus musculus GN=Znf207 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29741 BP_3 359.57 3.71 4967 642932977 XP_008197213.1 329 2.3e-27 PREDICTED: BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JMD0 137 1.7e-06 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Mus musculus GN=Znf207 PE=2 SV=1 PF06003//PF10403 Survival motor neuron protein (SMN)//Rad4 beta-hairpin domain 1 GO:0006397 mRNA processing GO:0003677//GO:0003723 DNA binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.29742 BP_3 16.94 0.70 1455 91076222 XP_972737.1 577 1.2e-56 PREDICTED: protein phosphatase methylesterase 1 [Tribolium castaneum]>gi|270014549|gb|EFA10997.1| hypothetical protein TcasGA2_TC004582 [Tribolium castaneum] -- -- -- -- -- K13617 PPME1 protein phosphatase methylesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13617 Q4FZT2 336 4.3e-30 Protein phosphatase methylesterase 1 OS=Rattus norvegicus GN=Ppme1 PE=1 SV=2 PF12740//PF01764//PF07819//PF00975 Chlorophyllase enzyme//Lipase (class 3)//PGAP1-like protein//Thioesterase domain GO:0009058//GO:0006505//GO:0015996//GO:0015994//GO:0006886//GO:0006629 biosynthetic process//GPI anchor metabolic process//chlorophyll catabolic process//chlorophyll metabolic process//intracellular protein transport//lipid metabolic process GO:0016788//GO:0016787//GO:0047746 hydrolase activity, acting on ester bonds//hydrolase activity//chlorophyllase activity -- -- KOG2564 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold Cluster-8309.29744 BP_3 2.00 0.69 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29747 BP_3 423.14 9.06 2544 189238410 XP_001813192.1 393 4.4e-35 PREDICTED: uncharacterized protein LOC100141684 [Tribolium castaneum]>gi|270008536|gb|EFA04984.1| hypothetical protein TcasGA2_TC015062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29752 BP_3 13.83 0.44 1812 270001107 EEZ97554.1 1785 1.2e-196 hypothetical protein TcasGA2_TC011404 [Tribolium castaneum] 195447877 XM_002071375.1 63 7.7516e-22 Drosophila willistoni GK25150 (Dwil\GK25150), mRNA K04365 BRAF B-Raf proto-oncogene serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04365 P11346 1376 1.3e-150 Raf homolog serine/threonine-protein kinase phl OS=Drosophila melanogaster GN=phl PE=1 SV=6 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0193 Serine/threonine protein kinase RAF Cluster-8309.29753 BP_3 521.00 14.50 2023 749786148 XP_011146725.1 471 3.2e-44 PREDICTED: vesicle transport protein SFT2B isoform X2 [Harpegnathos saltator]>gi|307199039|gb|EFN79763.1| Vesicle transport protein SFT2B [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- Q5SSN7 349 1.8e-31 Vesicle transport protein SFT2A OS=Mus musculus GN=Sft2d1 PE=1 SV=1 PF04178 Got1/Sft2-like family GO:0016192 vesicle-mediated transport -- -- -- -- KOG2887 Membrane protein involved in ER to Golgi transport Cluster-8309.29755 BP_3 11.16 0.73 1026 91089873 XP_971596.1 949 6.0e-100 PREDICTED: ruvB-like helicase 1 [Tribolium castaneum]>gi|270014274|gb|EFA10722.1| pontin [Tribolium castaneum] 552828675 XM_005847470.1 59 7.24335e-20 Chlorella variabilis hypothetical protein (CHLNCDRAFT_48800) mRNA, complete cds K04499 RUVBL1, RVB1, INO80H RuvB-like protein 1 (pontin 52) http://www.genome.jp/dbget-bin/www_bget?ko:K04499 Q0IFL2 827 3.5e-87 RuvB-like helicase 1 OS=Aedes aegypti GN=pont PE=3 SV=1 PF06068//PF05496//PF00004 TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0032508//GO:0006281 DNA recombination//DNA duplex unwinding//DNA repair GO:0009378//GO:0005524//GO:0003678 four-way junction helicase activity//ATP binding//DNA helicase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG1942 DNA helicase, TBP-interacting protein Cluster-8309.29757 BP_3 3596.61 39.43 4688 91089655 XP_974084.1 2180 5.0e-242 PREDICTED: protein wntless [Tribolium castaneum]>gi|270011339|gb|EFA07787.1| hypothetical protein TcasGA2_TC005345 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4LC58 1542 2.0e-169 Protein wntless OS=Drosophila virilis GN=wls PE=3 SV=1 PF00651 BTB/POZ domain GO:0016055 Wnt signaling pathway GO:0017147//GO:0005515 Wnt-protein binding//protein binding -- -- -- -- Cluster-8309.29758 BP_3 81.42 0.62 6665 478249797 ENN70304.1 1981 8.4e-219 hypothetical protein YQE_12815, partial [Dendroctonus ponderosae] -- -- -- -- -- K17785 IMMT, FCJ1, MNOS2 mitofilin http://www.genome.jp/dbget-bin/www_bget?ko:K17785 P91928 1173 1.7e-126 MICOS complex subunit Mic60 OS=Drosophila melanogaster GN=Mitofilin PE=1 SV=4 PF10759//PF01557//PF01632 Protein of unknown function (DUF2587)//Fumarylacetoacetate (FAA) hydrolase family//Ribosomal protein L35 GO:0061136//GO:0008152//GO:0006412//GO:0042254 regulation of proteasomal protein catabolic process//metabolic process//translation//ribosome biogenesis GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1854 Mitochondrial inner membrane protein (mitofilin) Cluster-8309.2976 BP_3 934.22 14.25 3451 189237068 XP_001809825.1 330 1.2e-27 PREDICTED: cuticle protein 7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 263 2.9e-21 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.29760 BP_3 9.99 0.93 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04508 Viral A-type inclusion protein repeat GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.29761 BP_3 3323.81 42.82 4033 91094941 XP_967472.1 5527 0.0e+00 PREDICTED: coatomer subunit alpha [Tribolium castaneum]>gi|270016760|gb|EFA13206.1| hypothetical protein TcasGA2_TC016033 [Tribolium castaneum] 642939609 XM_962379.3 577 0 PREDICTED: Tribolium castaneum coatomer subunit alpha (LOC655819), mRNA K05236 COPA coatomer protein complex, subunit alpha (xenin) http://www.genome.jp/dbget-bin/www_bget?ko:K05236 P53621 4596 0.0e+00 Coatomer subunit alpha OS=Homo sapiens GN=COPA PE=1 SV=2 PF00400//PF06957//PF13414//PF04053 WD domain, G-beta repeat//Coatomer (COPI) alpha subunit C-terminus//TPR repeat//Coatomer WD associated region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG0292 Vesicle coat complex COPI, alpha subunit Cluster-8309.29762 BP_3 679.56 7.09 4909 642914151 XP_008201566.1 5261 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04426 MAP3K5, ASK1 mitogen-activated protein kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04426 Q6ZN16 2572 7.5e-289 Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens GN=MAP3K15 PE=1 SV=2 PF07647//PF07714//PF00069 SAM domain (Sterile alpha motif)//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG4279 Serine/threonine protein kinase Cluster-8309.29764 BP_3 21.44 0.61 1977 332376416 AEE63348.1 742 1.2e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 343 8.9e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.29765 BP_3 25.70 0.69 2097 478254618 ENN74861.1 748 2.5e-76 hypothetical protein YQE_08631, partial [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 343 9.5e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF07043//PF06687//PF00230//PF05094 Protein of unknown function (DUF1328)//SUR7/PalI family//Major intrinsic protein//Late expression factor 9 (LEF-9) GO:0006810//GO:0019083 transport//viral transcription GO:0005215 transporter activity GO:0016020//GO:0005886 membrane//plasma membrane -- -- Cluster-8309.29767 BP_3 8.31 0.44 1197 91087325 XP_975591.1 363 6.3e-32 PREDICTED: ribonuclease kappa [Tribolium castaneum]>gi|270009525|gb|EFA05973.1| hypothetical protein TcasGA2_TC008797 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSF5 272 9.2e-23 Ribonuclease kappa OS=Drosophila melanogaster GN=CG40127 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29768 BP_3 1934.69 113.96 1110 91087325 XP_975591.1 403 1.3e-36 PREDICTED: ribonuclease kappa [Tribolium castaneum]>gi|270009525|gb|EFA05973.1| hypothetical protein TcasGA2_TC008797 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSF5 312 2.0e-27 Ribonuclease kappa OS=Drosophila melanogaster GN=CG40127 PE=3 SV=1 PF00649 Copper fist DNA binding domain GO:0009303//GO:0006355//GO:0051252 rRNA transcription//regulation of transcription, DNA-templated//regulation of RNA metabolic process GO:0003677//GO:0005507//GO:0004521//GO:0003700 DNA binding//copper ion binding//endoribonuclease activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.2977 BP_3 97.13 8.65 833 642928075 XP_008200145.1 322 2.5e-27 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270010867|gb|EFA07315.1| hypothetical protein TcasGA2_TC015908 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 267 2.4e-22 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.29772 BP_3 680.14 16.45 2284 189240899 XP_972980.2 1372 1.2e-148 PREDICTED: protein numb isoform X1 [Tribolium castaneum] 642934703 XM_008199556.1 373 0 PREDICTED: Tribolium castaneum protein numb (LOC661741), transcript variant X2, mRNA K06057 NUMBL numb http://www.genome.jp/dbget-bin/www_bget?ko:K06057 P16554 1074 1.8e-115 Protein numb OS=Drosophila melanogaster GN=numb PE=1 SV=2 PF07353//PF00640//PF14719//PF08168 Uroplakin II//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID)//NUC205 domain GO:0061024 membrane organization GO:0005515 protein binding GO:0030176//GO:0005634 integral component of endoplasmic reticulum membrane//nucleus KOG3537 Adaptor protein NUMB Cluster-8309.29773 BP_3 360.00 7.79 2520 189238529 XP_972715.2 1384 5.4e-150 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009088|gb|EFA05536.1| hypothetical protein TcasGA2_TC015723 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 749 9.5e-78 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF01266//PF00732//PF07992//PF05834//PF05199 FAD dependent oxidoreductase//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.29774 BP_3 77.00 1.94 2203 91094133 XP_966520.1 2156 1.4e-239 PREDICTED: delta(24)-sterol reductase [Tribolium castaneum]>gi|270010866|gb|EFA07314.1| hypothetical protein TcasGA2_TC015907 [Tribolium castaneum] -- -- -- -- -- K09828 DHCR24 delta24-sterol reductase http://www.genome.jp/dbget-bin/www_bget?ko:K09828 Q15392 917 2.7e-97 Delta(24)-sterol reductase OS=Homo sapiens GN=DHCR24 PE=1 SV=2 PF01565 FAD binding domain GO:0006040//GO:0055114 amino sugar metabolic process//oxidation-reduction process GO:0050660//GO:0008762//GO:0016491 flavin adenine dinucleotide binding//UDP-N-acetylmuramate dehydrogenase activity//oxidoreductase activity -- -- KOG1262 FAD-binding protein DIMINUTO Cluster-8309.29775 BP_3 18.24 0.42 2396 478253990 ENN74282.1 275 2.0e-21 hypothetical protein YQE_09254, partial [Dendroctonus ponderosae]>gi|546673736|gb|ERL85292.1| hypothetical protein D910_02713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29777 BP_3 570.21 11.03 2784 642939522 XP_008190961.1 1874 9.0e-207 PREDICTED: dual specificity protein phosphatase CDC14B isoform X1 [Tribolium castaneum]>gi|642939524|ref|XP_008190966.1| PREDICTED: dual specificity protein phosphatase CDC14B isoform X1 [Tribolium castaneum] -- -- -- -- -- K06639 CDC14 cell division cycle 14 http://www.genome.jp/dbget-bin/www_bget?ko:K06639 Q6GQT0 1212 2.1e-131 Dual specificity protein phosphatase CDC14A OS=Mus musculus GN=Cdc14a PE=2 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.29778 BP_3 40.85 3.51 853 478251481 ENN71944.1 320 4.3e-27 hypothetical protein YQE_11378, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2978 BP_3 39.49 0.79 2705 270006363 EFA02811.1 1275 2.5e-137 eyegone [Tribolium castaneum] -- -- -- -- -- K15608 PAX2 paired box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15608 P06601 328 6.7e-29 Segmentation protein paired OS=Drosophila melanogaster GN=prd PE=1 SV=1 PF00046//PF00292 Homeobox domain//'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.29780 BP_3 468.39 10.65 2412 642927926 XP_001814448.2 1898 1.3e-209 PREDICTED: LOW QUALITY PROTEIN: membralin [Tribolium castaneum] 642927925 XM_001814396.2 309 1.84114e-158 PREDICTED: Tribolium castaneum membralin (LOC663408), mRNA -- -- -- -- Q4ZIN3 1161 1.5e-125 Membralin OS=Homo sapiens GN=TMEM259 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2092 Uncharacterized conserved protein Cluster-8309.29781 BP_3 79.60 13.26 581 642935129 XP_008197899.1 152 8.9e-08 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29782 BP_3 1093.79 8.58 6436 642938747 XP_008199872.1 2423 4.6e-270 PREDICTED: cytosolic purine 5'-nucleotidase isoform X2 [Tribolium castaneum] 41393060 NM_201427.1 39 6.12449e-08 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1766 2.9e-195 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.29785 BP_3 1649.00 23.34 3697 189233949 XP_001815164.1 3461 0.0e+00 PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911540|ref|XP_008199465.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911543|ref|XP_008199466.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum] 801398844 XM_012204509.1 230 2.33549e-114 PREDICTED: Atta cephalotes striatin-interacting protein 1 (LOC105623108), mRNA -- -- -- -- Q5VSL9 2171 1.8e-242 Striatin-interacting protein 1 OS=Homo sapiens GN=STRIP1 PE=1 SV=1 PF07462//PF02428 Merozoite surface protein 1 (MSP1) C-terminus//Potato type II proteinase inhibitor family GO:0009405 pathogenesis GO:0004867 serine-type endopeptidase inhibitor activity GO:0016020 membrane KOG3680 Uncharacterized conserved protein Cluster-8309.29786 BP_3 937.43 17.48 2876 91083819 XP_973530.1 1648 1.5e-180 PREDICTED: trifunctional enzyme subunit alpha, mitochondrial [Tribolium castaneum] -- -- -- -- -- K07515 HADHA enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07515 P40939 1176 3.3e-127 Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2 PF03446//PF00725//PF01210//PF02609//PF02737//PF16113//PF00378 NAD binding domain of 6-phosphogluconate dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Exonuclease VII small subunit//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0006574//GO:0006550//GO:0019521//GO:0006568//GO:0055114//GO:0006554//GO:0008152//GO:0006098//GO:0006633//GO:0018874//GO:0046168//GO:0006631//GO:0006308//GO:0006552 valine catabolic process//isoleucine catabolic process//D-gluconate metabolic process//tryptophan metabolic process//oxidation-reduction process//lysine catabolic process//metabolic process//pentose-phosphate shunt//fatty acid biosynthetic process//benzoate metabolic process//glycerol-3-phosphate catabolic process//fatty acid metabolic process//DNA catabolic process//leucine catabolic process GO:0016616//GO:0003857//GO:0004616//GO:0003824//GO:0016836//GO:0051287//GO:0008855//GO:0016491 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity//catalytic activity//hydro-lyase activity//NAD binding//exodeoxyribonuclease VII activity//oxidoreductase activity GO:0009318 exodeoxyribonuclease VII complex KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.29787 BP_3 12.30 0.40 1771 642924529 XP_008194333.1 1090 4.7e-116 PREDICTED: kinesin-like protein Klp10A [Tribolium castaneum] -- -- -- -- -- K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 P28740 768 4.2e-80 Kinesin-like protein KIF2A OS=Mus musculus GN=Kif2a PE=1 SV=2 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule KOG0246 Kinesin-like protein Cluster-8309.29789 BP_3 1611.48 44.00 2057 91088839 XP_970745.1 1383 5.7e-150 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] 642932363 XM_965652.3 444 0 PREDICTED: Tribolium castaneum RNA-binding protein lark (LOC659335), mRNA K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q94901 914 5.7e-97 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF00098//PF08777//PF00076//PF01788//PF16367 Zinc knuckle//RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PsbJ//RNA recognition motif GO:0015979 photosynthesis GO:0003723//GO:0000166//GO:0008270//GO:0003676//GO:0046872 RNA binding//nucleotide binding//zinc ion binding//nucleic acid binding//metal ion binding GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-8309.2979 BP_3 48.51 0.96 2722 270006363 EFA02811.1 1738 5.2e-191 eyegone [Tribolium castaneum] 194869840 XM_001972496.1 82 3.21094e-32 Drosophila erecta GG13832 (Dere\GG13832), mRNA K15608 PAX2 paired box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15608 P06601 380 6.3e-35 Segmentation protein paired OS=Drosophila melanogaster GN=prd PE=1 SV=1 PF05920//PF00292//PF00046 Homeobox KN domain//'Paired box' domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.29790 BP_3 1453.84 69.71 1297 478256475 ENN76660.1 1125 3.0e-120 hypothetical protein YQE_06839, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C854 499 4.7e-49 Myelin expression factor 2 OS=Mus musculus GN=Myef2 PE=1 SV=1 PF03468//PF00076 XS domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0031047 gene silencing by RNA GO:0003676 nucleic acid binding -- -- KOG4212 RNA-binding protein hnRNP-M Cluster-8309.29792 BP_3 26.72 0.62 2364 91081249 XP_975650.1 377 3.0e-33 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q5XIU9 280 2.2e-23 Membrane-associated progesterone receptor component 2 OS=Rattus norvegicus GN=Pgrmc2 PE=2 SV=1 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.29793 BP_3 7.00 17.64 287 108794573 ABG20822.1 339 9.1e-30 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 273 1.7e-23 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.29795 BP_3 6.43 0.31 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.29796 BP_3 54.33 4.43 883 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29797 BP_3 120.86 1.21 5107 91078490 XP_968588.1 2030 1.3e-224 PREDICTED: COP9 signalosome complex subunit 1 [Tribolium castaneum]>gi|270004016|gb|EFA00464.1| hypothetical protein TcasGA2_TC003322 [Tribolium castaneum] 642915516 XM_963495.3 360 0 PREDICTED: Tribolium castaneum COP9 signalosome complex subunit 1 (LOC657006), mRNA K12175 GPS1, COPS1, CSN1 COP9 signalosome complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12175 Q99LD4 1580 8.4e-174 COP9 signalosome complex subunit 1 OS=Mus musculus GN=Gps1 PE=1 SV=1 PF00515//PF01399//PF13414 Tetratricopeptide repeat//PCI domain//TPR repeat -- -- GO:0005515 protein binding -- -- KOG0686 COP9 signalosome, subunit CSN1 Cluster-8309.29799 BP_3 2816.26 23.96 5958 642932582 XP_008196911.1 6827 0.0e+00 PREDICTED: transcription elongation factor SPT6 isoform X1 [Tribolium castaneum]>gi|270011547|gb|EFA07995.1| hypothetical protein TcasGA2_TC005584 [Tribolium castaneum] 571562785 XM_006570424.1 121 1.47915e-53 PREDICTED: Apis mellifera transcription elongation factor SPT6-like (LOC410274), mRNA K11292 SUPT6H, SPT6 transcription elongation factor SPT6 http://www.genome.jp/dbget-bin/www_bget?ko:K11292 Q9W420 4243 0.0e+00 Transcription elongation factor SPT6 OS=Drosophila melanogaster GN=Spt6 PE=1 SV=1 PF00575//PF14641 S1 RNA binding domain//Helix-turn-helix DNA-binding domain of SPT6 GO:0006357//GO:0032784 regulation of transcription from RNA polymerase II promoter//regulation of DNA-templated transcription, elongation GO:0016788//GO:0003723//GO:0003676//GO:0003677 hydrolase activity, acting on ester bonds//RNA binding//nucleic acid binding//DNA binding -- -- KOG1856 Transcription elongation factor SPT6 Cluster-8309.298 BP_3 3.92 0.56 632 817186065 XP_012287521.1 464 6.4e-44 PREDICTED: uncharacterized protein LOC105703602 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29803 BP_3 9.19 0.34 1581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.29805 BP_3 514.00 18.62 1622 478251321 ENN71789.1 1307 2.9e-141 hypothetical protein YQE_11523, partial [Dendroctonus ponderosae]>gi|546673509|gb|ERL85095.1| hypothetical protein D910_02517 [Dendroctonus ponderosae] -- -- -- -- -- K09521 DNAJC1 DnaJ homolog subfamily C member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09521 Q61712 496 1.3e-48 DnaJ homolog subfamily C member 1 OS=Mus musculus GN=Dnajc1 PE=1 SV=1 PF07074 Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0006613 cotranslational protein targeting to membrane -- -- GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex KOG0724 Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains Cluster-8309.29806 BP_3 1076.72 30.40 1999 91076860 XP_974922.1 944 4.5e-99 PREDICTED: zinc finger protein Noc [Tribolium castaneum]>gi|270002778|gb|EEZ99225.1| no ocelli [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24423 499 7.3e-49 Zinc finger protein Noc OS=Drosophila melanogaster GN=noc PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.29807 BP_3 18.05 0.63 1670 91076860 XP_974922.1 827 1.4e-85 PREDICTED: zinc finger protein Noc [Tribolium castaneum]>gi|270002778|gb|EEZ99225.1| no ocelli [Tribolium castaneum] 242006977 XM_002424274.1 34 9.42395e-06 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- Q24423 407 2.9e-38 Zinc finger protein Noc OS=Drosophila melanogaster GN=noc PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.29808 BP_3 381.58 4.40 4468 642919809 XP_008192077.1 4552 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X2 [Tribolium castaneum] 642919808 XM_008193855.1 741 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X2, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1839 6.8e-204 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF05445//PF07714//PF00069//PF06293 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.29809 BP_3 2.00 18.03 246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29810 BP_3 44.52 1.42 1800 642911285 XP_008199356.1 1588 8.5e-174 PREDICTED: tyrosine-protein kinase CSK isoform X1 [Tribolium castaneum] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 P41239 1015 9.7e-109 Tyrosine-protein kinase CSK OS=Gallus gallus GN=CSK PE=2 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.29812 BP_3 1327.34 36.62 2039 91081755 XP_972918.1 2214 2.5e-246 PREDICTED: translation initiation factor eIF-2B subunit epsilon isoform X1 [Tribolium castaneum]>gi|270006269|gb|EFA02717.1| hypothetical protein TcasGA2_TC008441 [Tribolium castaneum] -- -- -- -- -- K03240 EIF2B5 translation initiation factor eIF-2B subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K03240 Q13144 922 6.7e-98 Translation initiation factor eIF-2B subunit epsilon OS=Homo sapiens GN=EIF2B5 PE=1 SV=3 PF02020//PF07959//PF00483 eIF4-gamma/eIF5/eIF2-epsilon//L-fucokinase//Nucleotidyl transferase GO:0016070//GO:0009058 RNA metabolic process//biosynthetic process GO:0016772//GO:0016740//GO:0016779//GO:0005515 transferase activity, transferring phosphorus-containing groups//transferase activity//nucleotidyltransferase activity//protein binding -- -- KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6) Cluster-8309.29815 BP_3 14.00 0.70 1257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29817 BP_3 11.21 0.93 873 642927459 XP_968905.2 454 1.3e-42 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q28719 289 7.2e-25 Prostaglandin reductase 1 OS=Oryctolagus cuniculus GN=PTGR1 PE=2 SV=1 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.29822 BP_3 490.38 5.08 4946 642928077 XP_008200146.1 1753 1.7e-192 PREDICTED: homer protein homolog 2 [Tribolium castaneum]>gi|270010897|gb|EFA07345.1| hypothetical protein TcasGA2_TC015941 [Tribolium castaneum] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 Q9QWW1 681 1.4e-69 Homer protein homolog 2 OS=Mus musculus GN=Homer2 PE=1 SV=1 PF16716//PF06703//PF13851//PF06810//PF10473//PF07989//PF03938//PF07926//PF00038//PF16940//PF15898 Bone marrow stromal antigen 2//Microsomal signal peptidase 25 kDa subunit (SPC25)//Growth-arrest specific micro-tubule binding//Phage minor structural protein GP20//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Outer membrane protein (OmpH-like)//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Chloroplast envelope transporter//cGMP-dependent protein kinase interacting domain GO:0051607//GO:0006465//GO:0048870//GO:0006606 defense response to virus//signal peptide processing//cell motility//protein import into nucleus GO:0042803//GO:0051082//GO:0019901//GO:0008233//GO:0005198//GO:0045502//GO:0008134 protein homodimerization activity//unfolded protein binding//protein kinase binding//peptidase activity//structural molecule activity//dynein binding//transcription factor binding GO:0030286//GO:0005667//GO:0009507//GO:0005787//GO:0016021//GO:0005815//GO:0031514//GO:0005882 dynein complex//transcription factor complex//chloroplast//signal peptidase complex//integral component of membrane//microtubule organizing center//motile cilium//intermediate filament -- -- Cluster-8309.29824 BP_3 74.29 1.64 2472 642916843 XP_008199526.1 668 5.6e-67 PREDICTED: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [Tribolium castaneum]>gi|270003073|gb|EEZ99520.1| hypothetical protein TcasGA2_TC000101 [Tribolium castaneum] -- -- -- -- -- K01482 DDAH, ddaH dimethylargininase http://www.genome.jp/dbget-bin/www_bget?ko:K01482 O08557 304 3.7e-26 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Rattus norvegicus GN=Ddah1 PE=1 SV=3 -- -- GO:0006807 nitrogen compound metabolic process GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0005737 cytoplasm -- -- Cluster-8309.29829 BP_3 15.11 0.55 1608 642935990 XP_008198259.1 455 1.8e-42 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 390 2.6e-36 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.29830 BP_3 14.00 1.48 748 478250947 ENN71431.1 331 2.0e-28 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MHZ9 133 7.6e-07 Collectin-46 OS=Bos taurus GN=CL46 PE=2 SV=1 PF04166//PF00211 Pyridoxal phosphate biosynthetic protein PdxA//Adenylate and Guanylate cyclase catalytic domain GO:0008615//GO:0035556//GO:0055114//GO:0009190//GO:0042816 pyridoxine biosynthetic process//intracellular signal transduction//oxidation-reduction process//cyclic nucleotide biosynthetic process//vitamin B6 metabolic process GO:0050570//GO:0016849//GO:0051287 4-hydroxythreonine-4-phosphate dehydrogenase activity//phosphorus-oxygen lyase activity//NAD binding -- -- -- -- Cluster-8309.29831 BP_3 60.40 1.28 2565 189239691 XP_974700.2 1611 2.6e-176 PREDICTED: probable phenylalanine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270010728|gb|EFA07176.1| hypothetical protein TcasGA2_TC010176 [Tribolium castaneum] -- -- -- -- -- K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 O16129 1377 1.5e-150 Probable phenylalanine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-phe PE=2 SV=3 PF01409//PF00152//PF03147 tRNA synthetases class II core domain (F)//tRNA synthetases class II (D, K and N)//Ferredoxin-fold anticodon binding domain GO:0043039//GO:0006571//GO:0000162//GO:0008033//GO:0009094//GO:0006418//GO:0006432 tRNA aminoacylation//tyrosine biosynthetic process//tryptophan biosynthetic process//tRNA processing//L-phenylalanine biosynthetic process//tRNA aminoacylation for protein translation//phenylalanyl-tRNA aminoacylation GO:0004812//GO:0000287//GO:0000166//GO:0004826//GO:0000049//GO:0005524 aminoacyl-tRNA ligase activity//magnesium ion binding//nucleotide binding//phenylalanine-tRNA ligase activity//tRNA binding//ATP binding GO:0005737//GO:0009328 cytoplasm//phenylalanine-tRNA ligase complex KOG2783 Phenylalanyl-tRNA synthetase Cluster-8309.29832 BP_3 167.00 5.04 1890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29833 BP_3 793.90 6.12 6540 91085969 XP_971641.1 2307 1.3e-256 PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927542|ref|XP_008195309.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927544|ref|XP_008195310.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927547|ref|XP_008195311.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum] -- -- -- -- -- K09239 HIVEP human immunodeficiency virus type I enhancer-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09239 A2A884 339 8.6e-30 Transcription factor HIVEP3 OS=Mus musculus GN=Hivep3 PE=1 SV=1 PF00651//PF00320//PF13465//PF00096 BTB/POZ domain//GATA zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0005515//GO:0003700//GO:0043565//GO:0008270 metal ion binding//protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667 transcription factor complex KOG1721 FOG: Zn-finger Cluster-8309.29834 BP_3 454.61 3.76 6125 91085969 XP_971641.1 2307 1.2e-256 PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927542|ref|XP_008195309.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927544|ref|XP_008195310.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927547|ref|XP_008195311.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum] -- -- -- -- -- K09239 HIVEP human immunodeficiency virus type I enhancer-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09239 A2A884 339 8.0e-30 Transcription factor HIVEP3 OS=Mus musculus GN=Hivep3 PE=1 SV=1 PF00096//PF13465//PF00651 Zinc finger, C2H2 type//Zinc-finger double domain//BTB/POZ domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.29835 BP_3 45.76 1.30 1989 642930094 XP_008196249.1 2272 4.6e-253 PREDICTED: uncharacterized protein LOC655867 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P01267 128 7.6e-06 Thyroglobulin OS=Bos taurus GN=TG PE=1 SV=1 PF01424//PF00095//PF12740//PF02822 R3H domain//WAP-type (Whey Acidic Protein) 'four-disulfide core'//Chlorophyllase enzyme//Antistasin family GO:0015996//GO:0015994 chlorophyll catabolic process//chlorophyll metabolic process GO:0003676//GO:0047746//GO:0004867//GO:0030414 nucleic acid binding//chlorophyllase activity//serine-type endopeptidase inhibitor activity//peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.29838 BP_3 784.20 22.47 1974 332375851 AEE63066.1 1156 1.2e-123 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 P17439 819 5.7e-86 Glucosylceramidase OS=Mus musculus GN=Gba PE=1 SV=1 PF02806//PF02055 Alpha amylase, C-terminal all-beta domain//O-Glycosyl hydrolase family 30 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348//GO:0043169//GO:0003824 glucosylceramidase activity//cation binding//catalytic activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.2984 BP_3 82.91 8.93 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29842 BP_3 26.00 1.03 1512 332374088 AEE62185.1 881 6.8e-92 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8CAK1 377 7.8e-35 Putative transferase CAF17 homolog, mitochondrial OS=Mus musculus GN=Iba57 PE=1 SV=1 PF09128//PF04053 Regulator of G protein signalling-like domain//Coatomer WD associated region GO:0043087//GO:0016192//GO:0006886 regulation of GTPase activity//vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005089 structural molecule activity//Rho guanyl-nucleotide exchange factor activity GO:0030117//GO:0005737 membrane coat//cytoplasm KOG2929 Transcription factor, component of CCR4 transcriptional complex Cluster-8309.29844 BP_3 33.31 0.58 3083 642929332 XP_973791.2 2166 1.4e-240 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum]>gi|270010511|gb|EFA06959.1| hypothetical protein TcasGA2_TC009917 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.29847 BP_3 42.00 1.02 2280 91084407 XP_967001.1 633 5.9e-63 PREDICTED: uncharacterized protein LOC655368 [Tribolium castaneum]>gi|270008706|gb|EFA05154.1| hypothetical protein TcasGA2_TC015272 [Tribolium castaneum] 797056887 HG313992.1 77 1.61571e-29 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 14 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29848 BP_3 80.00 5.07 1053 642911178 XP_008200613.1 269 4.4e-21 PREDICTED: DNA-directed RNA polymerase II subunit GRINL1A [Tribolium castaneum]>gi|270014682|gb|EFA11130.1| hypothetical protein TcasGA2_TC004731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15328//PF00527 Putative GRINL1B complex locus protein 2//E7 protein, Early protein GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0016591 transcription factor complex//DNA-directed RNA polymerase II, holoenzyme -- -- Cluster-8309.2985 BP_3 169.45 9.93 1114 478255888 ENN76095.1 152 1.7e-07 hypothetical protein YQE_07378, partial [Dendroctonus ponderosae]>gi|478266978|gb|ENN82965.1| hypothetical protein YQE_00671, partial [Dendroctonus ponderosae]>gi|478269605|gb|ENN83363.1| hypothetical protein YQE_00278, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P11734 143 7.8e-08 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29850 BP_3 39.35 10.56 471 642930498 XP_008196429.1 461 1.1e-43 PREDICTED: CLIP-associating protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q9NBD7 274 2.1e-23 CLIP-associating protein OS=Drosophila melanogaster GN=chb PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29852 BP_3 102.62 3.78 1602 642925526 XP_008194587.1 1323 4.0e-143 PREDICTED: probable low-specificity L-threonine aldolase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 727 2.1e-75 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF01053//PF01212//PF00155 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG1368 Threonine aldolase Cluster-8309.29859 BP_3 190.36 16.06 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29860 BP_3 39.77 1.26 1810 270007657 EFA04105.1 866 4.5e-90 hypothetical protein TcasGA2_TC014342 [Tribolium castaneum] -- -- -- -- -- K11406 HDAC4_5 histone deacetylase 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11406 Q9Z2V6 180 6.5e-12 Histone deacetylase 5 OS=Mus musculus GN=Hdac5 PE=1 SV=2 PF12899//PF00481//PF04216 Alkaline and neutral invertase//Protein phosphatase 2C//Protein involved in formate dehydrogenase formation -- -- GO:0033926//GO:0003824 glycopeptide alpha-N-acetylgalactosaminidase activity//catalytic activity GO:0005737 cytoplasm -- -- Cluster-8309.29861 BP_3 747.53 12.07 3276 270007657 EFA04105.1 3170 0.0e+00 hypothetical protein TcasGA2_TC014342 [Tribolium castaneum] 642923488 XM_962332.3 720 0 PREDICTED: Tribolium castaneum histone deacetylase 7 (LOC655770), mRNA K11406 HDAC4_5 histone deacetylase 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11406 Q9Z2V6 1410 2.8e-154 Histone deacetylase 5 OS=Mus musculus GN=Hdac5 PE=1 SV=2 PF12899//PF00481 Alkaline and neutral invertase//Protein phosphatase 2C -- -- GO:0033926//GO:0003824 glycopeptide alpha-N-acetylgalactosaminidase activity//catalytic activity -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.29862 BP_3 1162.64 8.53 6864 642925954 XP_008195644.1 2092 1.2e-231 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 1367 5.6e-149 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF01480//PF03015//PF01370//PF00076//PF00309//PF01400//PF01429//PF00642//PF01073 PWI domain//Male sterility protein//NAD dependent epimerase/dehydratase family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Sigma-54 factor, Activator interacting domain (AID)//Astacin (Peptidase family M12A)//Methyl-CpG binding domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0006206//GO:0006508//GO:0006352//GO:0006351//GO:0006397//GO:0008210//GO:0006144//GO:0006355//GO:0008207//GO:0055114//GO:0006694//GO:0008209 pyrimidine nucleobase metabolic process//proteolysis//DNA-templated transcription, initiation//transcription, DNA-templated//mRNA processing//estrogen metabolic process//purine nucleobase metabolic process//regulation of transcription, DNA-templated//C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process GO:0003676//GO:0016987//GO:0046872//GO:0003824//GO:0003677//GO:0080019//GO:0003700//GO:0004222//GO:0003854//GO:0003899//GO:0050662//GO:0016616 nucleic acid binding//sigma factor activity//metal ion binding//catalytic activity//DNA binding//fatty-acyl-CoA reductase (alcohol-forming) activity//transcription factor activity, sequence-specific DNA binding//metalloendopeptidase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//DNA-directed RNA polymerase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005634//GO:0005667//GO:0005730 nucleus//transcription factor complex//nucleolus KOG1221 Acyl-CoA reductase Cluster-8309.29865 BP_3 329.00 9.61 1941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29866 BP_3 26.39 0.35 3912 642922441 XP_008193170.1 2349 1.1e-261 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 642922836 XM_008195125.1 330 6.36018e-170 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X1, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1931 1.3e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF00479//PF02781//PF00180//PF10538 Glucose-6-phosphate dehydrogenase, NAD binding domain//Glucose-6-phosphate dehydrogenase, C-terminal domain//Isocitrate/isopropylmalate dehydrogenase//Immunoreceptor tyrosine-based activation motif GO:0006006//GO:0006749//GO:0006098//GO:0007165//GO:0055114 glucose metabolic process//glutathione metabolic process//pentose-phosphate shunt//signal transduction//oxidation-reduction process GO:0050661//GO:0016616//GO:0004345 NADP binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glucose-6-phosphate dehydrogenase activity -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.29867 BP_3 182.83 1.53 6046 546675274 ERL86510.1 3789 0.0e+00 hypothetical protein D910_03914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR5 714 2.6e-73 GTPase-activating protein and VPS9 domain-containing protein 1 OS=Mus musculus GN=Gapvd1 PE=1 SV=2 PF00616//PF02881 GTPase-activator protein for Ras-like GTPase//SRP54-type protein, helical bundle domain GO:0043087//GO:0006614 regulation of GTPase activity//SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.29869 BP_3 66.00 8.83 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29870 BP_3 119.07 2.28 2812 642917912 XP_008191379.1 679 3.4e-68 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P36512 332 2.4e-29 UDP-glucuronosyltransferase 2B13 OS=Oryctolagus cuniculus GN=UGT2B13 PE=2 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.29871 BP_3 413.90 10.62 2170 642917912 XP_008191379.1 1038 6.1e-110 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 569 6.1e-57 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.29872 BP_3 20.00 1.17 1116 642928708 XP_008199749.1 260 5.1e-20 PREDICTED: uncharacterized protein LOC662585 isoform X11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29873 BP_3 318.00 19.69 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29877 BP_3 45.48 0.76 3183 91092214 XP_969938.1 2127 4.7e-236 PREDICTED: uncharacterized protein LOC658457 [Tribolium castaneum]>gi|270014434|gb|EFA10882.1| hypothetical protein TcasGA2_TC001706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48613 198 9.3e-14 Protein tipE OS=Drosophila melanogaster GN=tipE PE=2 SV=1 PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.29878 BP_3 3.20 0.71 509 357606614 EHJ65136.1 469 1.4e-44 hypothetical protein KGM_05509 [Danaus plexippus] 795059903 XM_012017609.1 129 4.24997e-59 PREDICTED: Vollenhovia emeryi uncharacterized LOC105564872 (LOC105564872), mRNA -- -- -- -- A1ZA47 426 5.4e-41 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.29879 BP_3 116.81 4.44 1561 642913680 XP_008201115.1 852 1.6e-88 PREDICTED: protein amalgam-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29882 BP_3 269.89 9.58 1649 546681591 ERL91655.1 1100 3.0e-117 hypothetical protein D910_08983, partial [Dendroctonus ponderosae] 642917222 XM_963027.2 298 1.62865e-152 PREDICTED: Tribolium castaneum splicing factor 3B subunit 4 (LOC656501), mRNA K12831 SF3B4, SAP49 splicing factor 3B subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12831 Q15427 1030 1.6e-110 Splicing factor 3B subunit 4 OS=Homo sapiens GN=SF3B4 PE=1 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0131 Splicing factor 3b, subunit 4 Cluster-8309.29884 BP_3 1721.10 53.34 1847 478251864 ENN72303.1 1127 2.5e-120 hypothetical protein YQE_11046, partial [Dendroctonus ponderosae]>gi|546674377|gb|ERL85764.1| hypothetical protein D910_03179 [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 1.2e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.29886 BP_3 492.44 1.34 17964 642935122 XP_008197897.1 26028 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 1002 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q61555 1378 7.8e-150 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF06553//PF07645//PF00008 BNIP3//Calcium-binding EGF domain//EGF-like domain GO:0043065 positive regulation of apoptotic process GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.29887 BP_3 570.07 10.10 3011 478250663 ENN71155.1 1488 5.6e-162 hypothetical protein YQE_12086, partial [Dendroctonus ponderosae]>gi|546677247|gb|ERL88116.1| hypothetical protein D910_05505 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 801 1.1e-83 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF00487//PF08320 Fatty acid desaturase//PIG-X / PBN1 GO:0006506//GO:0006629 GPI anchor biosynthetic process//lipid metabolic process -- -- GO:0005789 endoplasmic reticulum membrane KOG0537 Cytochrome b5 Cluster-8309.29888 BP_3 508.02 4.56 5657 642933837 XP_008197529.1 1903 7.9e-210 PREDICTED: epsin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q3SZ63 1185 5.9e-128 Nucleolar protein 56 OS=Bos taurus GN=NOP56 PE=2 SV=1 PF02376//PF05557 CUT domain//Mitotic checkpoint protein GO:0007094 mitotic spindle assembly checkpoint GO:0003677 DNA binding -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-8309.29891 BP_3 88.15 1.57 2995 642925692 XP_008194672.1 1905 2.5e-210 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 4.51149e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q9NP58 1393 2.4e-152 ATP-binding cassette sub-family B member 6, mitochondrial OS=Homo sapiens GN=ABCB6 PE=1 SV=1 PF00503//PF00005//PF03193//PF06414//PF00004//PF02224//PF01583//PF07728//PF00664//PF13304//PF01926 G-protein alpha subunit//ABC transporter//Protein of unknown function, DUF258//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0007165//GO:0055085//GO:0006139//GO:0006810//GO:0006200//GO:0007186//GO:0006144//GO:0000103//GO:0006206 signal transduction//transmembrane transport//nucleobase-containing compound metabolic process//transport//obsolete ATP catabolic process//G-protein coupled receptor signaling pathway//purine nucleobase metabolic process//sulfate assimilation//pyrimidine nucleobase metabolic process GO:0005524//GO:0031683//GO:0003924//GO:0004127//GO:0019001//GO:0016887//GO:0016301//GO:0042626//GO:0004020//GO:0005525//GO:0004871 ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//cytidylate kinase activity//guanyl nucleotide binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//adenylylsulfate kinase activity//GTP binding//signal transducer activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29892 BP_3 695.00 30.98 1373 332374126 AEE62204.1 1134 2.9e-121 unknown [Dendroctonus ponderosae]>gi|478256630|gb|ENN76812.1| hypothetical protein YQE_06653, partial [Dendroctonus ponderosae]>gi|546685174|gb|ERL94701.1| hypothetical protein D910_11975 [Dendroctonus ponderosae] -- -- -- -- -- K10258 TER, TSC13, CER10 very-long-chain enoyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10258 Q9N5Y2 847 2.2e-89 Probable very-long-chain enoyl-CoA reductase art-1 OS=Caenorhabditis elegans GN=art-1 PE=3 SV=1 PF00240//PF02544 Ubiquitin family//3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627//GO:0005515 oxidoreductase activity, acting on the CH-CH group of donors//protein binding GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG1639 Steroid reductase required for elongation of the very long chain fatty acids Cluster-8309.29893 BP_3 100.04 5.72 1135 642925692 XP_008194672.1 736 3.3e-75 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] -- -- -- -- -- K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 561 2.7e-56 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF00005 ABC transporter GO:0006200//GO:0006810//GO:0055085 obsolete ATP catabolic process//transport//transmembrane transport GO:0042626//GO:0005524//GO:0016887 ATPase activity, coupled to transmembrane movement of substances//ATP binding//ATPase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29894 BP_3 179.00 2.89 3277 642925692 XP_008194672.1 3452 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 4.94144e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 2168 3.5e-242 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF00005//PF03193//PF06414//PF07728//PF01583//PF00664//PF01926//PF13304//PF00004//PF02224 ABC transporter//Protein of unknown function, DUF258//Zeta toxin//AAA domain (dynein-related subfamily)//Adenylylsulphate kinase//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase GO:0006206//GO:0000103//GO:0006144//GO:0055085//GO:0006139//GO:0006200//GO:0006810 pyrimidine nucleobase metabolic process//sulfate assimilation//purine nucleobase metabolic process//transmembrane transport//nucleobase-containing compound metabolic process//obsolete ATP catabolic process//transport GO:0005525//GO:0004020//GO:0016301//GO:0016887//GO:0004127//GO:0042626//GO:0005524//GO:0003924 GTP binding//adenylylsulfate kinase activity//kinase activity//ATPase activity//cytidylate kinase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29895 BP_3 112.43 1.78 3331 642925692 XP_008194672.1 3452 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 5.02378e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 2168 3.6e-242 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF02224//PF00004//PF01583//PF07728//PF01926//PF13304//PF00664//PF03193//PF00005//PF06414 Cytidylate kinase//ATPase family associated with various cellular activities (AAA)//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter//Zeta toxin GO:0006144//GO:0000103//GO:0006206//GO:0006810//GO:0006139//GO:0006200//GO:0055085 purine nucleobase metabolic process//sulfate assimilation//pyrimidine nucleobase metabolic process//transport//nucleobase-containing compound metabolic process//obsolete ATP catabolic process//transmembrane transport GO:0004020//GO:0005525//GO:0003924//GO:0005524//GO:0042626//GO:0016301//GO:0004127//GO:0016887 adenylylsulfate kinase activity//GTP binding//GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//kinase activity//cytidylate kinase activity//ATPase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29896 BP_3 948.38 17.31 2933 642925692 XP_008194672.1 3452 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 4.41696e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 2168 3.2e-242 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF00664//PF13304//PF01926//PF01583//PF07728//PF00004//PF02224//PF06414//PF00005//PF03193 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0006139//GO:0006200//GO:0055085//GO:0006206//GO:0006144//GO:0000103 transport//nucleobase-containing compound metabolic process//obsolete ATP catabolic process//transmembrane transport//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//sulfate assimilation GO:0042626//GO:0016887//GO:0004127//GO:0016301//GO:0003924//GO:0005524//GO:0005525//GO:0004020 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//cytidylate kinase activity//kinase activity//GTPase activity//ATP binding//GTP binding//adenylylsulfate kinase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29898 BP_3 247.00 14.51 1112 332372905 AEE61594.1 639 5.8e-64 unknown [Dendroctonus ponderosae]>gi|546674532|gb|ERL85892.1| hypothetical protein D910_03307 [Dendroctonus ponderosae] -- -- -- -- -- K17412 MRPS34 small subunit ribosomal protein S34 http://www.genome.jp/dbget-bin/www_bget?ko:K17412 P82929 157 1.9e-09 28S ribosomal protein S34, mitochondrial OS=Bos taurus GN=MRPS34 PE=1 SV=2 PF16053 Mitochondrial 28S ribosomal protein S34 GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0005739 ribosome//mitochondrion -- -- Cluster-8309.299 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08407 Chitin synthase N-terminal GO:0006031 chitin biosynthetic process GO:0004100 chitin synthase activity -- -- -- -- Cluster-8309.29900 BP_3 6348.00 35.53 8903 642937796 XP_008200304.1 11335 0.0e+00 PREDICTED: notch isoform X1 [Tribolium castaneum] 665794822 XM_008546906.1 396 0 PREDICTED: Microplitis demolitor neurogenic locus Notch protein (LOC103569561), transcript variant X2, mRNA K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 P07207 7969 0.0e+00 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF00023//PF07684//PF13606//PF00008//PF06816//PF07645 Ankyrin repeat//NOTCH protein//Ankyrin repeat//EGF-like domain//NOTCH protein//Calcium-binding EGF domain GO:0007275//GO:0030154//GO:0007219 multicellular organismal development//cell differentiation//Notch signaling pathway GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.29901 BP_3 171.00 4.47 2136 91085389 XP_966562.1 1515 2.9e-165 PREDICTED: solute carrier family 35 member G1 [Tribolium castaneum]>gi|270009150|gb|EFA05598.1| hypothetical protein TcasGA2_TC015802 [Tribolium castaneum] 815768624 XM_012376721.1 50 1.54451e-14 PREDICTED: Linepithema humile solute carrier family 35 member G1-like (LOC105677844), mRNA -- -- -- -- Q2M3R5 586 6.4e-59 Solute carrier family 35 member G1 OS=Homo sapiens GN=SLC35G1 PE=1 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4510 Permease of the drug/metabolite transporter (DMT) superfamily Cluster-8309.29903 BP_3 545.00 17.19 1820 642928295 XP_008195522.1 628 1.8e-62 PREDICTED: calponin homology domain-containing protein DDB_G0272472-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29904 BP_3 28.25 1.14 1490 546680624 ERL90862.1 233 9.3e-17 hypothetical protein D910_08207 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF01663//PF00539 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Transactivating regulatory protein (Tat) GO:0008152//GO:0006355 metabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0008484//GO:0003824 transcription factor activity, sequence-specific DNA binding//sulfuric ester hydrolase activity//catalytic activity GO:0005667//GO:0042025 transcription factor complex//host cell nucleus -- -- Cluster-8309.29905 BP_3 31.74 0.34 4806 270010125 EFA06573.1 1283 5.3e-138 hypothetical protein TcasGA2_TC009484 [Tribolium castaneum] 642927258 XM_969189.2 139 1.17468e-63 PREDICTED: Tribolium castaneum uncharacterized LOC663129 (LOC663129), mRNA K17776 MTX metaxin http://www.genome.jp/dbget-bin/www_bget?ko:K17776 Q2L969 681 1.4e-69 Metaxin-2 OS=Sus scrofa GN=MTX2 PE=2 SV=1 PF13903//PF10568 PMP-22/EMP/MP20/Claudin tight junction//Outer mitochondrial membrane transport complex protein GO:0006626 protein targeting to mitochondrion -- -- GO:0016021//GO:0005741 integral component of membrane//mitochondrial outer membrane KOG3027 Mitochondrial outer membrane protein Metaxin 2, Metaxin 1-binding protein Cluster-8309.29910 BP_3 699.02 8.23 4385 642926721 XP_008194985.1 1671 4.9e-183 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 552 1.2e-54 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.29912 BP_3 94.05 2.98 1814 642928919 XP_008195616.1 1164 1.3e-124 PREDICTED: beclin-1-like protein [Tribolium castaneum] 831317244 XM_012835846.1 40 4.73707e-09 PREDICTED: Clupea harengus beclin 1, autophagy related (becn1), transcript variant X2, mRNA K08334 BECN1, VPS30, ATG6 beclin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08334 Q9VCE1 897 4.7e-95 Beclin-1-like protein OS=Drosophila melanogaster GN=Atg6 PE=2 SV=1 PF04420//PF04111//PF07851//PF06156 CHD5-like protein//Autophagy protein Apg6//TMPIT-like protein//Protein of unknown function (DUF972) GO:0006914//GO:0071816//GO:0006260 autophagy//tail-anchored membrane protein insertion into ER membrane//DNA replication -- -- GO:0016021 integral component of membrane KOG2751 Beclin-like protein Cluster-8309.29913 BP_3 8.64 0.31 1642 189241335 XP_001809545.1 1796 5.9e-198 PREDICTED: innexin inx3 [Tribolium castaneum]>gi|270013143|gb|EFA09591.1| hypothetical protein TcasGA2_TC011709 [Tribolium castaneum] 642936310 XM_001809493.2 422 0 PREDICTED: Tribolium castaneum innexin inx3 (LOC100141896), mRNA -- -- -- -- Q9VAS7 1318 6.5e-144 Innexin inx3 OS=Drosophila melanogaster GN=Inx3 PE=1 SV=1 PF06662//PF01292//PF00876 D-glucuronyl C5-epimerase C-terminus//Prokaryotic cytochrome b561//Innexin GO:0006024//GO:0006118 glycosaminoglycan biosynthetic process//obsolete electron transport GO:0009055//GO:0016857 electron carrier activity//racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016021//GO:0005921 integral component of membrane//gap junction -- -- Cluster-8309.29918 BP_3 150.17 3.87 2162 646682520 KDR02319.1 1568 2.1e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.50775e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.0e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF00937//PF07714//PF00069 Coronavirus nucleocapsid protein//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.29919 BP_3 1081.54 14.99 3770 270014920 EFA11368.1 3829 0.0e+00 hypothetical protein TcasGA2_TC011526 [Tribolium castaneum] 701357390 XM_010007485.1 90 1.59413e-36 PREDICTED: Chaetura pelagica ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), mRNA K01537 E3.6.3.8 Ca2+-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01537 Q80XR2 2536 8.7e-285 Calcium-transporting ATPase type 2C member 1 OS=Mus musculus GN=Atp2c1 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.29920 BP_3 20.32 0.69 1706 91080235 XP_972829.1 164 1.1e-08 PREDICTED: caprin homolog [Tribolium castaneum]>gi|270005626|gb|EFA02074.1| hypothetical protein TcasGA2_TC007709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0003333//GO:0006865 amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.29921 BP_3 1288.86 15.14 4394 642935654 XP_008198101.1 3404 0.0e+00 PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935656|ref|XP_008198102.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935658|ref|XP_008198103.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum] 817215019 XM_012428261.1 140 2.98394e-64 PREDICTED: Orussus abietinus uncharacterized LOC105701487 (LOC105701487), mRNA K07817 PTPRN receptor-type tyrosine-protein phosphatase N http://www.genome.jp/dbget-bin/www_bget?ko:K07817 O02695 1329 9.2e-145 Receptor-type tyrosine-protein phosphatase N2 OS=Macaca nemestrina GN=PTPRN2 PE=2 SV=1 PF00782//PF00102//PF10590 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region GO:0006570//GO:0006470//GO:0055114 tyrosine metabolic process//protein dephosphorylation//oxidation-reduction process GO:0004725//GO:0016638//GO:0008138 protein tyrosine phosphatase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//protein tyrosine/serine/threonine phosphatase activity -- -- KOG0793 Protein tyrosine phosphatase Cluster-8309.29922 BP_3 3.00 5.53 300 -- -- -- -- -- 642935657 XM_008199881.1 66 2.50494e-24 PREDICTED: Tribolium castaneum receptor-type tyrosine-protein phosphatase N2 (LOC663427), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29923 BP_3 1699.31 17.53 4963 642917633 XP_008193409.1 5050 0.0e+00 PREDICTED: DNA topoisomerase 2 [Tribolium castaneum] 158299571 XM_319665.4 602 0 Anopheles gambiae str. PEST AGAP008917-PA (AgaP_AGAP008917) mRNA, partial cds K03164 TOP2 DNA topoisomerase II http://www.genome.jp/dbget-bin/www_bget?ko:K03164 O16140 4530 0.0e+00 DNA topoisomerase 2 OS=Bombyx mori GN=TOP2 PE=2 SV=1 PF00204//PF02969//PF00521 DNA gyrase B//TATA box binding protein associated factor (TAF)//DNA gyrase/topoisomerase IV, subunit A GO:0006265//GO:0006352 DNA topological change//DNA-templated transcription, initiation GO:0003677//GO:0003918//GO:0005524 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding GO:0005634 nucleus KOG0355 DNA topoisomerase type II Cluster-8309.29926 BP_3 586.16 4.56 6485 478255038 ENN75270.1 2558 1.0e-285 hypothetical protein YQE_08186, partial [Dendroctonus ponderosae]>gi|546673325|gb|ERL84953.1| hypothetical protein D910_02376 [Dendroctonus ponderosae] -- -- -- -- -- K14301 NUP107, NUP84 nuclear pore complex protein Nup107 http://www.genome.jp/dbget-bin/www_bget?ko:K14301 Q8BH74 1282 3.8e-139 Nuclear pore complex protein Nup107 OS=Mus musculus GN=Nup107 PE=2 SV=1 PF00514//PF04121//PF01465 Armadillo/beta-catenin-like repeat//Nuclear pore protein 84 / 107//GRIP domain GO:0006810//GO:0000042 transport//protein targeting to Golgi GO:0005515 protein binding GO:0005643 nuclear pore KOG1964 Nuclear pore complex, rNup107 component (sc Nup84) Cluster-8309.29927 BP_3 815.17 14.18 3063 642934707 XP_973046.2 3089 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 54 [Tribolium castaneum] -- -- -- -- -- K17600 VPS54 vacuolar protein sorting-associated protein 54 http://www.genome.jp/dbget-bin/www_bget?ko:K17600 Q9VLC0 1746 2.8e-193 Vacuolar protein sorting-associated protein 54 OS=Drosophila melanogaster GN=scat PE=1 SV=1 PF07928//PF04048 Vps54-like protein//Sec8 exocyst complex component specific domain GO:0006904//GO:0015031//GO:0042147 vesicle docking involved in exocytosis//protein transport//retrograde transport, endosome to Golgi -- -- GO:0000145 exocyst KOG2115 Vacuolar sorting protein VPS45 Cluster-8309.29928 BP_3 87.83 1.58 2971 642934707 XP_973046.2 3085 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 54 [Tribolium castaneum] -- -- -- -- -- K17600 VPS54 vacuolar protein sorting-associated protein 54 http://www.genome.jp/dbget-bin/www_bget?ko:K17600 Q9VLC0 1746 2.7e-193 Vacuolar protein sorting-associated protein 54 OS=Drosophila melanogaster GN=scat PE=1 SV=1 PF04048//PF07928 Sec8 exocyst complex component specific domain//Vps54-like protein GO:0006904//GO:0042147//GO:0015031 vesicle docking involved in exocytosis//retrograde transport, endosome to Golgi//protein transport -- -- GO:0000145 exocyst KOG2115 Vacuolar sorting protein VPS45 Cluster-8309.29929 BP_3 8802.96 157.83 2980 546678277 ERL88938.1 2764 6.1e-310 hypothetical protein D910_06316 [Dendroctonus ponderosae] 676485074 XM_009065298.1 66 2.7594e-23 Lottia gigantea hypothetical protein partial mRNA K11141 ENPEP glutamyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11141 Q07075 1739 1.8e-192 Glutamyl aminopeptidase OS=Homo sapiens GN=ENPEP PE=1 SV=3 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.29930 BP_3 39.00 0.67 3079 546678277 ERL88938.1 2704 5.7e-303 hypothetical protein D910_06316 [Dendroctonus ponderosae] 676485074 XM_009065298.1 66 2.85219e-23 Lottia gigantea hypothetical protein partial mRNA K11141 ENPEP glutamyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11141 Q07075 1680 1.3e-185 Glutamyl aminopeptidase OS=Homo sapiens GN=ENPEP PE=1 SV=3 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.29931 BP_3 6.51 0.46 968 91079340 XP_969318.1 910 1.9e-95 PREDICTED: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [Tribolium castaneum]>gi|270004890|gb|EFA01338.1| NADH dehydrogenase (ubiquinone) flavoprotein 2 [Tribolium castaneum] -- -- -- -- -- K03943 NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03943 Q0MQI8 706 3.5e-73 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Gorilla gorilla gorilla GN=NDUFV2 PE=2 SV=1 -- -- GO:0055114 oxidation-reduction process GO:0016491//GO:0046872//GO:0051537 oxidoreductase activity//metal ion binding//2 iron, 2 sulfur cluster binding -- -- KOG3196 NADH:ubiquinone oxidoreductase, NDUFV2/24 kD subunit Cluster-8309.29932 BP_3 600.55 15.64 2143 642916941 XP_008199564.1 845 1.4e-87 PREDICTED: mitochondrial import inner membrane translocase subunit Tim23 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17794 TIM23 mitochondrial import inner membrane translocase subunit TIM23 http://www.genome.jp/dbget-bin/www_bget?ko:K17794 Q9WTQ8 390 3.4e-36 Mitochondrial import inner membrane translocase subunit Tim23 OS=Mus musculus GN=Timm23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3324 Mitochondrial import inner membrane translocase, subunit TIM23 Cluster-8309.29933 BP_3 13.73 0.33 2322 332376863 AEE63571.1 693 6.6e-70 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17794 TIM23 mitochondrial import inner membrane translocase subunit TIM23 http://www.genome.jp/dbget-bin/www_bget?ko:K17794 Q9WTQ8 339 3.0e-30 Mitochondrial import inner membrane translocase subunit Tim23 OS=Mus musculus GN=Timm23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3324 Mitochondrial import inner membrane translocase, subunit TIM23 Cluster-8309.29934 BP_3 6.21 0.43 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29935 BP_3 507.00 13.75 2069 478255559 ENN75776.1 567 2.4e-55 hypothetical protein YQE_07733, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VB74 523 1.3e-51 UPF0396 protein CG6066 OS=Drosophila melanogaster GN=CG6066 PE=1 SV=1 PF08290 Hepatitis core protein, putative zinc finger GO:0009405 pathogenesis GO:0005198 structural molecule activity -- -- KOG2812 Uncharacterized conserved protein Cluster-8309.29936 BP_3 12462.65 102.98 6125 826464184 XP_012534808.1 1355 3.0e-146 PREDICTED: titin [Monomorium pharaonis] 642936078 XM_008200072.1 229 1.39708e-113 PREDICTED: Tribolium castaneum titin (LOC663321), transcript variant X2, mRNA -- -- -- -- Q9I7U4 184 7.6e-12 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29937 BP_3 13.00 2.70 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29939 BP_3 132.30 4.69 1652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29940 BP_3 54.70 1.87 1702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29941 BP_3 215.00 2.36 4675 189233655 XP_967467.2 2575 7.8e-288 PREDICTED: potassium voltage-gated channel protein Shal [Tribolium castaneum]>gi|270014520|gb|EFA10968.1| hypothetical protein TcasGA2_TC004130 [Tribolium castaneum] 642910598 XM_962374.3 735 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shal (LOC655814), mRNA K05321 KCNDN potassium voltage-gated channel Shal-related subfamily D, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05321 P17971 2411 3.4e-270 Potassium voltage-gated channel protein Shal OS=Drosophila melanogaster GN=Shal PE=1 SV=2 PF00520//PF02214 Ion transport protein//BTB/POZ domain GO:0055085//GO:0071805//GO:0051260//GO:0006813//GO:0006811//GO:0034765 transmembrane transport//potassium ion transmembrane transport//protein homooligomerization//potassium ion transport//ion transport//regulation of ion transmembrane transport GO:0005216//GO:0005249 ion channel activity//voltage-gated potassium channel activity GO:0016020//GO:0008076 membrane//voltage-gated potassium channel complex KOG4390 Voltage-gated A-type K+ channel KCND Cluster-8309.29942 BP_3 30.02 2.42 889 642934609 XP_008197736.1 681 6.2e-69 PREDICTED: corepressor interacting with RBPJ 1 [Tribolium castaneum]>gi|270013741|gb|EFA10189.1| hypothetical protein TcasGA2_TC012381 [Tribolium castaneum] 815894066 XM_012381482.1 149 5.81661e-70 PREDICTED: Bombus impatiens corepressor interacting with RBPJ 1 (LOC100748315), mRNA K06066 CIR CBF1 interacting corepressor http://www.genome.jp/dbget-bin/www_bget?ko:K06066 Q5ZI03 430 3.3e-41 Corepressor interacting with RBPJ 1 OS=Gallus gallus GN=CIR1 PE=2 SV=1 PF07496 CW-type Zinc Finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG3794 CBF1-interacting corepressor CIR and related proteins Cluster-8309.29945 BP_3 155.96 4.10 2125 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29946 BP_3 344.00 11.07 1790 642911762 XP_008200730.1 1745 5.3e-192 PREDICTED: major facilitator superfamily domain-containing protein 12-like isoform X1 [Tribolium castaneum]>gi|270014551|gb|EFA10999.1| hypothetical protein TcasGA2_TC004584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUT3 833 1.2e-87 Major facilitator superfamily domain-containing protein 12 OS=Homo sapiens GN=MFSD12 PE=1 SV=2 PF02674//PF00083//PF07690 Colicin V production protein//Sugar (and other) transporter//Major Facilitator Superfamily GO:0009403//GO:0055085 toxin biosynthetic process//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG4830 Predicted sugar transporter Cluster-8309.29948 BP_3 67.00 1.36 2673 546680798 ERL91004.1 1903 3.8e-210 hypothetical protein D910_08346 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q91WR3 248 1.3e-19 Activating signal cointegrator 1 complex subunit 2 OS=Mus musculus GN=Ascc2 PE=2 SV=1 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29949 BP_3 192.60 3.64 2839 642927274 XP_008195202.1 896 2.3e-93 PREDICTED: protein N-terminal glutamine amidohydrolase isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q968 652 1.9e-66 Protein N-terminal glutamine amidohydrolase OS=Anopheles gambiae GN=tun PE=3 SV=3 PF09764 N-terminal glutamine amidase GO:0006807 nitrogen compound metabolic process GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides -- -- KOG3261 Uncharacterized conserved protein Cluster-8309.29950 BP_3 51.48 2.10 1476 91083261 XP_966859.1 720 3.1e-73 PREDICTED: uncharacterized protein LOC663006 [Tribolium castaneum]>gi|270007764|gb|EFA04212.1| hypothetical protein TcasGA2_TC014461 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF00822//PF13903//PF05039 Clc-like//PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction//Agouti protein GO:0009755 hormone-mediated signaling pathway -- -- GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.29951 BP_3 2683.52 114.54 1421 332375068 AEE62675.1 1019 6.4e-108 unknown [Dendroctonus ponderosae]>gi|478252468|gb|ENN72890.1| hypothetical protein YQE_10460, partial [Dendroctonus ponderosae]>gi|546682586|gb|ERL92505.1| hypothetical protein D910_09818 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF13903//PF05039 Clc-like//PMP-22/EMP/MP20/Claudin tight junction//Agouti protein GO:0009755 hormone-mediated signaling pathway -- -- GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.29952 BP_3 135.65 1.50 4662 642914151 XP_008201566.1 5110 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04426 MAP3K5, ASK1 mitogen-activated protein kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04426 Q6ZN16 2507 2.5e-281 Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens GN=MAP3K15 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG4279 Serine/threonine protein kinase Cluster-8309.29953 BP_3 6.00 1.27 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29956 BP_3 110.02 1.70 3420 478257812 ENN77955.1 340 8.3e-29 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0042254//GO:0001522 cellular protein modification process//ribosome biogenesis//pseudouridine synthesis GO:0030515//GO:0016151 snoRNA binding//nickel cation binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.29957 BP_3 477.18 5.75 4294 642912192 XP_008200846.1 742 2.5e-75 PREDICTED: transmembrane protein 127-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGP5 217 7.9e-16 Transmembrane protein 127 OS=Mus musculus GN=Tmem127 PE=2 SV=1 PF00515//PF04799 Tetratricopeptide repeat//fzo-like conserved region GO:0008053 mitochondrial fusion GO:0005515//GO:0003924 protein binding//GTPase activity GO:0016021//GO:0005741 integral component of membrane//mitochondrial outer membrane -- -- Cluster-8309.29958 BP_3 31.42 1.06 1717 478250751 ENN71243.1 328 1.0e-27 hypothetical protein YQE_12170, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2996 BP_3 10.00 0.33 1743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01828 Peptidase A4 family GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.29961 BP_3 5.00 0.33 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29962 BP_3 22.02 0.98 1375 478257926 ENN78065.1 145 1.4e-06 hypothetical protein YQE_05459, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29963 BP_3 55.57 0.68 4225 549438535 AGX25156.1 1145 4.7e-122 thiol-disulfide isomerase [Leptinotarsa decemlineata] 157137765 XM_001663984.1 86 2.9926e-34 Aedes aegypti AAEL013845-RA partial mRNA K17264 ERP44, TXNDC4 endoplasmic reticulum resident protein 44 http://www.genome.jp/dbget-bin/www_bget?ko:K17264 Q9D1Q6 663 1.5e-67 Endoplasmic reticulum resident protein 44 OS=Mus musculus GN=Erp44 PE=1 SV=1 PF00085//PF01216 Thioredoxin//Calsequestrin GO:0045454 cell redox homeostasis GO:0005509 calcium ion binding -- -- KOG0912 Thiol-disulfide isomerase and thioredoxin Cluster-8309.29964 BP_3 130.42 1.70 3990 642933365 XP_008197385.1 4600 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29966 BP_3 233.89 8.87 1563 728416984 AIY68330.1 1381 7.4e-150 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 621 4.1e-63 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.29967 BP_3 475.66 22.15 1327 403234001 AFR31785.1 1037 4.9e-110 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P08836 486 1.6e-47 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.29969 BP_3 193.09 5.99 1846 546686194 ERL95574.1 592 2.7e-58 hypothetical protein D910_12835 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 242 4.3e-19 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF07776//PF06467//PF11648//PF00096//PF16622//PF01428//PF01844//PF13912//PF02892//PF00412//PF07975//PF13465 Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//C-terminal domain of RIG-I//Zinc finger, C2H2 type//zinc-finger C2H2-type//AN1-like Zinc finger//HNH endonuclease//C2H2-type zinc finger//BED zinc finger//LIM domain//TFIIH C1-like domain//Zinc-finger double domain GO:0006281 DNA repair GO:0003677//GO:0004519//GO:0003676//GO:0008270//GO:0046872//GO:0016817 DNA binding//endonuclease activity//nucleic acid binding//zinc ion binding//metal ion binding//hydrolase activity, acting on acid anhydrides GO:0005634 nucleus -- -- Cluster-8309.29970 BP_3 7533.20 30.80 12081 642920697 XP_008192527.1 625 2.6e-61 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202//PF04443//PF09726 Adipogenin//Acyl-protein synthetase, LuxE//Transmembrane protein GO:0008218//GO:0045444 bioluminescence//fat cell differentiation GO:0047474 long-chain fatty acid luciferin component ligase activity GO:0016021 integral component of membrane -- -- Cluster-8309.29971 BP_3 59.04 1.10 2885 189238011 XP_001813334.1 378 2.8e-33 PREDICTED: SH3 domain-binding glutamic acid-rich protein homolog [Tribolium castaneum]>gi|270008052|gb|EFA04500.1| hypothetical protein TcasGA2_TC014808 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NFP5 353 9.0e-32 SH3 domain-binding glutamic acid-rich protein homolog OS=Drosophila melanogaster GN=Sh3beta PE=1 SV=2 PF02798//PF00462 Glutathione S-transferase, N-terminal domain//Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG4023 Uncharacterized conserved protein Cluster-8309.29972 BP_3 2.00 0.49 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29973 BP_3 613.03 4.53 6814 642921666 XP_008192914.1 2161 1.2e-239 PREDICTED: polycomb protein Asx isoform X1 [Tribolium castaneum]>gi|270007351|gb|EFA03799.1| hypothetical protein TcasGA2_TC013912 [Tribolium castaneum] -- -- -- -- -- K11471 ASXL additional sex combs-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11471 Q9V727 566 4.3e-56 Polycomb protein Asx OS=Drosophila melanogaster GN=Asx PE=1 SV=1 PF13922//PF12515 PHD domain of transcriptional enhancer, Asx//Ca2+-ATPase N terminal autoinhibitory domain -- -- GO:0005516//GO:0003677 calmodulin binding//DNA binding -- -- -- -- Cluster-8309.29974 BP_3 103.68 1.56 3485 642915698 XP_008190764.1 3282 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X2 [Tribolium castaneum] 642915697 XM_008192542.1 550 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X2, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 5.3e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.29975 BP_3 23.31 0.55 2345 478252719 ENN73114.1 1091 4.7e-116 hypothetical protein YQE_10255, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q62418 624 2.8e-63 Drebrin-like protein OS=Mus musculus GN=Dbnl PE=1 SV=2 PF00241//PF00957//PF14604//PF00018 Cofilin/tropomyosin-type actin-binding protein//Synaptobrevin//Variant SH3 domain//SH3 domain GO:0016192 vesicle-mediated transport GO:0005515//GO:0003779 protein binding//actin binding GO:0005622//GO:0016021 intracellular//integral component of membrane KOG3655 Drebrins and related actin binding proteins Cluster-8309.29977 BP_3 1396.00 110.80 899 282158103 NP_001164095.1 377 1.1e-33 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 P19109 273 5.3e-23 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.29980 BP_3 388.63 5.35 3794 91083631 XP_970382.1 3795 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.50541e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2955 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF00005//PF02233//PF00107//PF07074//PF00205//PF02826//PF03188//PF01752 ABC transporter//NAD(P) transhydrogenase beta subunit//Zinc-binding dehydrogenase//Translocon-associated protein, gamma subunit (TRAP-gamma)//Thiamine pyrophosphate enzyme, central domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Collagenase GO:0006508//GO:0015992//GO:0006769//GO:0055114//GO:0006613//GO:0046497 proteolysis//proton transport//nicotinamide metabolic process//oxidation-reduction process//cotranslational protein targeting to membrane//nicotinate nucleotide metabolic process GO:0030976//GO:0000287//GO:0050661//GO:0051287//GO:0008270//GO:0016887//GO:0004252//GO:0005524//GO:0008750 thiamine pyrophosphate binding//magnesium ion binding//NADP binding//NAD binding//zinc ion binding//ATPase activity//serine-type endopeptidase activity//ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity GO:0005576//GO:0030176//GO:0005784//GO:0016021 extracellular region//integral component of endoplasmic reticulum membrane//Sec61 translocon complex//integral component of membrane -- -- Cluster-8309.29981 BP_3 2.00 0.35 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023 Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29982 BP_3 352.00 33.38 800 91086587 XP_973540.1 618 1.1e-61 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [Tribolium castaneum]>gi|270011002|gb|EFA07450.1| hypothetical protein TcasGA2_TC009080 [Tribolium castaneum] -- -- -- -- -- K03965 NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03965 Q9CQJ8 339 1.0e-30 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Mus musculus GN=Ndufb9 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3466 NADH:ubiquinone oxidoreductase, NDUFB9/B22 subunit Cluster-8309.29985 BP_3 336.11 5.87 3051 91079394 XP_971791.1 765 3.9e-78 PREDICTED: centrosomin isoform X2 [Tribolium castaneum] -- -- -- -- -- K16542 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16542 Q9BE52 259 7.6e-21 CDK5 regulatory subunit-associated protein 2 OS=Macaca fascicularis GN=CDK5RAP2 PE=2 SV=1 PF01221//PF07989//PF00769//PF02183 Dynein light chain type 1//Centrosomin N-terminal motif 1//Ezrin/radixin/moesin family//Homeobox associated leucine zipper GO:0006355//GO:0007017 regulation of transcription, DNA-templated//microtubule-based process GO:0008092//GO:0043565//GO:0003700 cytoskeletal protein binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0019898//GO:0005875//GO:0005815//GO:0005667//GO:0005737 extrinsic component of membrane//microtubule associated complex//microtubule organizing center//transcription factor complex//cytoplasm -- -- Cluster-8309.29986 BP_3 841.88 25.73 1869 817216800 XP_012284405.1 719 5.2e-73 PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus]>gi|817216802|ref|XP_012284407.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q9TU03 480 1.1e-46 Rho GDP-dissociation inhibitor 2 OS=Bos taurus GN=ARHGDIB PE=2 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.29993 BP_3 615.68 10.86 3025 91082539 XP_973726.1 1448 2.4e-157 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 800 1.4e-83 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29994 BP_3 118.21 1.02 5886 270014769 EFA11217.1 1194 1.4e-127 hypothetical protein TcasGA2_TC005181 [Tribolium castaneum] 158299715 XM_319761.3 144 2.39371e-66 Anopheles gambiae str. PEST AGAP009016-PA (AgaP_AGAP009016) mRNA, complete cds K16673 LIX1L LIX1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K16673 Q8IVB5 1021 6.4e-109 LIX1-like protein OS=Homo sapiens GN=LIX1L PE=2 SV=1 PF05887//PF03368 Procyclic acidic repetitive protein (PARP)//Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GO:0016020 membrane -- -- Cluster-8309.29996 BP_3 3476.09 42.38 4245 642911211 XP_008199614.1 1434 1.4e-155 PREDICTED: LIX1-like protein [Tribolium castaneum] 158299715 XM_319761.3 144 1.72224e-66 Anopheles gambiae str. PEST AGAP009016-PA (AgaP_AGAP009016) mRNA, complete cds K16673 LIX1L LIX1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K16673 Q8IVB5 1016 1.8e-108 LIX1-like protein OS=Homo sapiens GN=LIX1L PE=2 SV=1 PF03368//PF05887 Dicer dimerisation domain//Procyclic acidic repetitive protein (PARP) GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GO:0016020 membrane -- -- Cluster-8309.29997 BP_3 66.66 0.55 6181 642911211 XP_008199614.1 676 1.6e-67 PREDICTED: LIX1-like protein [Tribolium castaneum] 158299715 XM_319761.3 94 1.56778e-38 Anopheles gambiae str. PEST AGAP009016-PA (AgaP_AGAP009016) mRNA, complete cds K16673 LIX1L LIX1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K16673 Q8IVB5 542 2.3e-53 LIX1-like protein OS=Homo sapiens GN=LIX1L PE=2 SV=1 PF05887//PF03368 Procyclic acidic repetitive protein (PARP)//Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GO:0016020 membrane -- -- Cluster-8309.29998 BP_3 86.47 0.99 4498 546681097 ERL91253.1 2497 8.4e-279 hypothetical protein D910_08588 [Dendroctonus ponderosae] 820837626 XM_003690680.2 92 1.4726e-37 PREDICTED: Apis florea syntaxin-5 (LOC100868396), mRNA -- -- -- -- Q24179 2001 1.1e-222 Protein sly1 homolog OS=Drosophila melanogaster GN=Slh PE=2 SV=4 PF00995//PF00992//PF08131//PF05739//PF16519//PF00804 Sec1 family//Troponin//Defensin-like peptide family//SNARE domain//Tetramerisation domain of TRPM//Syntaxin GO:0051262//GO:0016192//GO:0006904 protein tetramerization//vesicle-mediated transport//vesicle docking involved in exocytosis GO:0005515 protein binding GO:0016020//GO:0005576//GO:0005861 membrane//extracellular region//troponin complex KOG1301 Vesicle trafficking protein Sly1 (Sec1 family) Cluster-8309.300 BP_3 2.00 0.42 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30001 BP_3 14.54 1.02 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05281 Neuroendocrine protein 7B2 precursor (Secretogranin V) GO:0007218 neuropeptide signaling pathway -- -- GO:0030141 secretory granule -- -- Cluster-8309.30004 BP_3 14.00 1.79 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30005 BP_3 112.67 0.87 6513 646700010 KDR10365.1 926 1.8e-96 Angiopoietin-related protein 1 [Zootermopsis nevadensis] 578359011 KJ186851.1 44 1.02986e-10 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-4) mRNA, complete cds -- -- -- -- Q9UKU9 544 1.4e-53 Angiopoietin-related protein 2 OS=Homo sapiens GN=ANGPTL2 PE=2 SV=1 PF04513//PF01607//PF04136//PF06009 Baculovirus polyhedron envelope protein, PEP, C terminus//Chitin binding Peritrophin-A domain//Sec34-like family//Laminin Domain II GO:0006886//GO:0006030//GO:0007155 intracellular protein transport//chitin metabolic process//cell adhesion GO:0005198//GO:0008061 structural molecule activity//chitin binding GO:0019031//GO:0019028//GO:0016020//GO:0005801//GO:0005576 viral envelope//viral capsid//membrane//cis-Golgi network//extracellular region -- -- Cluster-8309.30006 BP_3 36.00 2.08 1125 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30007 BP_3 110.35 4.50 1474 642915333 XP_008190576.1 324 2.6e-27 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K03904 FGB fibrinogen beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K03904 O95841 230 8.4e-18 Angiopoietin-related protein 1 OS=Homo sapiens GN=ANGPTL1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30008 BP_3 203.98 1.74 5936 646700010 KDR10365.1 926 1.6e-96 Angiopoietin-related protein 1 [Zootermopsis nevadensis] 578359011 KJ186851.1 49 1.55947e-13 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-4) mRNA, complete cds -- -- -- -- Q9UKU9 544 1.3e-53 Angiopoietin-related protein 2 OS=Homo sapiens GN=ANGPTL2 PE=2 SV=1 PF04136//PF01607//PF06009//PF04513 Sec34-like family//Chitin binding Peritrophin-A domain//Laminin Domain II//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007155//GO:0006886//GO:0006030 cell adhesion//intracellular protein transport//chitin metabolic process GO:0008061//GO:0005198 chitin binding//structural molecule activity GO:0005576//GO:0016020//GO:0005801//GO:0019031//GO:0019028 extracellular region//membrane//cis-Golgi network//viral envelope//viral capsid -- -- Cluster-8309.30009 BP_3 1.00 21.77 224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3001 BP_3 6.00 0.33 1173 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04061 ORMDL family -- -- -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.30011 BP_3 5.85 0.74 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30012 BP_3 595.64 7.37 4186 642933107 XP_008197261.1 1670 6.1e-183 PREDICTED: prominin-like protein isoform X1 [Tribolium castaneum]>gi|270011437|gb|EFA07885.1| hypothetical protein TcasGA2_TC005459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 530 3.9e-52 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF05356//PF01442//PF05478//PF02417//PF13903//PF07464//PF07926//PF04513 Phage Coat protein B//Apolipoprotein A1/A4/E domain//Prominin//Chromate transporter//PMP-22/EMP/MP20/Claudin tight junction//Apolipophorin-III precursor (apoLp-III)//TPR/MLP1/MLP2-like protein//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0006606//GO:0006869//GO:0015703//GO:0042157 protein import into nucleus//lipid transport//chromate transport//lipoprotein metabolic process GO:0015109//GO:0005198//GO:0008289 chromate transmembrane transporter activity//structural molecule activity//lipid binding GO:0005576//GO:0019031//GO:0016021//GO:0019028 extracellular region//viral envelope//integral component of membrane//viral capsid KOG4331 Polytopic membrane protein Prominin Cluster-8309.30013 BP_3 486.76 6.13 4118 642928027 XP_008200126.1 1921 4.7e-212 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.91441e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 993 7.9e-106 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF13202//PF04728//PF03836//PF00036//PF12763//PF10186//PF01920//PF07851//PF16326//PF04111//PF05531//PF13499//PF13833//PF13405 EF hand//Lipoprotein leucine-zipper//RasGAP C-terminus//EF hand//Cytoskeletal-regulatory complex EF hand//Vacuolar sorting 38 and autophagy-related subunit 14//Prefoldin subunit//TMPIT-like protein//ABC transporter C-terminal domain//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein//EF-hand domain pair//EF-hand domain pair//EF-hand domain GO:0006914//GO:0006457//GO:0010508//GO:0007264 autophagy//protein folding//positive regulation of autophagy//small GTPase mediated signal transduction GO:0005515//GO:0003677//GO:0005096//GO:0051082//GO:0005509 protein binding//DNA binding//GTPase activator activity//unfolded protein binding//calcium ion binding GO:0019028//GO:0016021//GO:0019867//GO:0016272 viral capsid//integral component of membrane//outer membrane//prefoldin complex KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.30017 BP_3 21.17 0.51 2306 91082885 XP_971739.1 758 1.9e-77 PREDICTED: leucine-rich repeat extensin-like protein 3 [Tribolium castaneum]>gi|270007607|gb|EFA04055.1| hypothetical protein TcasGA2_TC014287 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0B9 157 3.8e-09 Zinc finger CCHC domain-containing protein 2 OS=Homo sapiens GN=ZCCHC2 PE=1 SV=6 PF03608 PTS system enzyme II sorbitol-specific factor GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0016021 integral component of membrane -- -- Cluster-8309.30019 BP_3 1112.45 17.45 3365 91093116 XP_967543.1 2214 4.1e-246 PREDICTED: serine/threonine-protein kinase GL21140 [Tribolium castaneum]>gi|270001184|gb|EEZ97631.1| hypothetical protein TcasGA2_TC016079 [Tribolium castaneum] -- -- -- -- -- K08805 DCLK1_2 doublecortin-like kinase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08805 B4IT27 1235 5.6e-134 Serine/threonine-protein kinase GE16371 OS=Drosophila yakuba GN=GE16371 PE=3 SV=2 PF06293//PF00069//PF07714//PF03607//PF00292 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Doublecortin//'Paired box' domain GO:0006355//GO:0035556//GO:0006468//GO:0009069//GO:0016310 regulation of transcription, DNA-templated//intracellular signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0004674//GO:0004672//GO:0005524//GO:0003677 phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity//ATP binding//DNA binding GO:0005622//GO:0016020 intracellular//membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.30024 BP_3 1930.18 35.40 2920 91076148 XP_970492.1 943 8.5e-99 PREDICTED: yorkie homolog isoform X1 [Tribolium castaneum]>gi|270014715|gb|EFA11163.1| hypothetical protein TcasGA2_TC004769 [Tribolium castaneum] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q45VV3 309 1.2e-26 Transcriptional coactivator yorkie OS=Drosophila melanogaster GN=yki PE=1 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.30025 BP_3 976.26 24.42 2219 478250226 ENN70727.1 932 1.2e-97 hypothetical protein YQE_12557, partial [Dendroctonus ponderosae]>gi|478270147|gb|ENN83468.1| hypothetical protein YQE_00176, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RBL0 456 7.9e-44 Protein YIPF1 OS=Pongo abelii GN=YIPF1 PE=2 SV=1 PF04893//PF15454//PF13291 Yip1 domain//Late endosomal/lysosomal adaptor and MAPK and MTOR activator//ACT domain GO:0001919//GO:0042632//GO:0043410//GO:0007040//GO:0032439//GO:0008152//GO:0071230//GO:0032008 regulation of receptor recycling//cholesterol homeostasis//positive regulation of MAPK cascade//lysosome organization//endosome localization//metabolic process//cellular response to amino acid stimulus//positive regulation of TOR signaling GO:0016597 amino acid binding GO:0045121//GO:0016020//GO:0031902//GO:0071986 membrane raft//membrane//late endosome membrane//Ragulator complex KOG3114 Uncharacterized conserved protein Cluster-8309.30026 BP_3 181.74 4.72 2149 478250226 ENN70727.1 932 1.2e-97 hypothetical protein YQE_12557, partial [Dendroctonus ponderosae]>gi|478270147|gb|ENN83468.1| hypothetical protein YQE_00176, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RBL0 456 7.6e-44 Protein YIPF1 OS=Pongo abelii GN=YIPF1 PE=2 SV=1 PF04893//PF15454//PF13291 Yip1 domain//Late endosomal/lysosomal adaptor and MAPK and MTOR activator//ACT domain GO:0042632//GO:0001919//GO:0043410//GO:0007040//GO:0071230//GO:0008152//GO:0032008//GO:0032439 cholesterol homeostasis//regulation of receptor recycling//positive regulation of MAPK cascade//lysosome organization//cellular response to amino acid stimulus//metabolic process//positive regulation of TOR signaling//endosome localization GO:0016597 amino acid binding GO:0045121//GO:0016020//GO:0031902//GO:0071986 membrane raft//membrane//late endosome membrane//Ragulator complex KOG3114 Uncharacterized conserved protein Cluster-8309.30028 BP_3 38.49 0.45 4444 642915079 XP_008190402.1 3503 0.0e+00 PREDICTED: unconventional myosin-IXa isoform X2 [Tribolium castaneum] 768442001 XM_011564452.1 506 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q9Z1N3 1894 2.8e-210 Unconventional myosin-IXa OS=Rattus norvegicus GN=Myo9a PE=1 SV=1 PF00788//PF00437//PF01990//PF00063//PF15177 Ras association (RalGDS/AF-6) domain//Type II/IV secretion system protein//ATP synthase (F/14-kDa) subunit//Myosin head (motor domain)//Interleukin-28A GO:0007165//GO:0007259//GO:0051607//GO:0050778//GO:0034220//GO:0006810 signal transduction//JAK-STAT cascade//defense response to virus//positive regulation of immune response//ion transmembrane transport//transport GO:0003774//GO:0005125//GO:0005524 motor activity//cytokine activity//ATP binding GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.30030 BP_3 441.53 5.00 4551 642928153 XP_008200179.1 3557 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 1A isoform X2 [Tribolium castaneum] -- -- -- -- -- K11655 BAZ1A, ACF1 bromodomain adjacent to zinc finger domain protein 1A http://www.genome.jp/dbget-bin/www_bget?ko:K11655 Q9NRL2 535 1.1e-52 Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens GN=BAZ1A PE=1 SV=2 PF00628//PF00439 PHD-finger//Bromodomain -- -- GO:0005515 protein binding -- -- KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.30031 BP_3 300.05 8.02 2096 91083309 XP_974698.1 2406 1.4e-268 PREDICTED: xaa-Pro aminopeptidase 1 [Tribolium castaneum]>gi|270007740|gb|EFA04188.1| hypothetical protein TcasGA2_TC014437 [Tribolium castaneum] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q9NQW7 1788 2.6e-198 Xaa-Pro aminopeptidase 1 OS=Homo sapiens GN=XPNPEP1 PE=1 SV=3 PF01321 Creatinase/Prolidase N-terminal domain GO:0009987 cellular process GO:0016787//GO:0046872 hydrolase activity//metal ion binding -- -- KOG2413 Xaa-Pro aminopeptidase Cluster-8309.30032 BP_3 1055.95 29.10 2041 91083309 XP_974698.1 2406 1.4e-268 PREDICTED: xaa-Pro aminopeptidase 1 [Tribolium castaneum]>gi|270007740|gb|EFA04188.1| hypothetical protein TcasGA2_TC014437 [Tribolium castaneum] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q9NQW7 1788 2.5e-198 Xaa-Pro aminopeptidase 1 OS=Homo sapiens GN=XPNPEP1 PE=1 SV=3 PF01321 Creatinase/Prolidase N-terminal domain GO:0009987 cellular process GO:0046872//GO:0016787 metal ion binding//hydrolase activity -- -- KOG2413 Xaa-Pro aminopeptidase Cluster-8309.30033 BP_3 189.05 1.10 8606 642923695 XP_008193847.1 5437 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 1636 4.5e-180 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF15723 Motility quorum-sensing regulator, toxin of MqsA GO:0009372//GO:0017148//GO:0042710 quorum sensing//negative regulation of translation//biofilm formation -- -- -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.30034 BP_3 1.45 0.47 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30035 BP_3 1189.28 7.13 8329 642923693 XP_008193845.1 4235 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 2136 4.6e-238 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF15723//PF03361 Motility quorum-sensing regulator, toxin of MqsA//Herpes virus intermediate/early protein 2/3 GO:0017148//GO:0042710//GO:0009372//GO:0006355 negative regulation of translation//biofilm formation//quorum sensing//regulation of transcription, DNA-templated -- -- -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.30036 BP_3 1538.97 9.00 8536 642923695 XP_008193847.1 6957 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 2117 7.6e-236 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF05927//PF03361//PF15723 Penaeidin//Herpes virus intermediate/early protein 2/3//Motility quorum-sensing regulator, toxin of MqsA GO:0009372//GO:0042710//GO:0017148//GO:0006355 quorum sensing//biofilm formation//negative regulation of translation//regulation of transcription, DNA-templated GO:0008061 chitin binding GO:0005737 cytoplasm KOG1893 Uncharacterized conserved protein Cluster-8309.30037 BP_3 24.86 1.48 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30038 BP_3 192.77 1.10 8766 642923695 XP_008193847.1 5437 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 1636 4.6e-180 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF15723 Motility quorum-sensing regulator, toxin of MqsA GO:0009372//GO:0042710//GO:0017148 quorum sensing//biofilm formation//negative regulation of translation -- -- -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.30039 BP_3 359.05 8.78 2263 91077058 XP_968505.1 2308 3.5e-257 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] 665802087 XM_008550863.1 127 2.57167e-57 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 Q0V7M0 1916 4.1e-213 Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1 PF02985//PF01749//PF16006//PF10508//PF11698//PF00514//PF01602 HEAT repeat//Importin beta binding domain//Nucleolar and spindle-associated protein//Proteasome non-ATPase 26S subunit//V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region GO:0043248//GO:0006606//GO:0015031//GO:0016192//GO:0006886//GO:0000281//GO:0000226//GO:0040001//GO:0015991 proteasome assembly//protein import into nucleus//protein transport//vesicle-mediated transport//intracellular protein transport//mitotic cytokinesis//microtubule cytoskeleton organization//establishment of mitotic spindle localization//ATP hydrolysis coupled proton transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0005737//GO:0030117//GO:0005819//GO:0005634//GO:0005874//GO:0000221 cytoplasm//membrane coat//spindle//nucleus//microtubule//vacuolar proton-transporting V-type ATPase, V1 domain KOG0166 Karyopherin (importin) alpha Cluster-8309.30040 BP_3 47.75 1.53 1792 91090512 XP_969653.1 670 2.4e-67 PREDICTED: transmembrane protein 177 [Tribolium castaneum]>gi|270013871|gb|EFA10319.1| hypothetical protein TcasGA2_TC012535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BPE4 262 2.0e-21 Transmembrane protein 177 OS=Mus musculus GN=Tmem177 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30041 BP_3 78.89 3.03 1547 91090512 XP_969653.1 798 2.9e-82 PREDICTED: transmembrane protein 177 [Tribolium castaneum]>gi|270013871|gb|EFA10319.1| hypothetical protein TcasGA2_TC012535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q53S58 308 8.0e-27 Transmembrane protein 177 OS=Homo sapiens GN=TMEM177 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30044 BP_3 4.00 0.61 606 642928380 XP_008192720.1 226 2.4e-16 PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|642928382|ref|XP_008192721.1| PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|270010784|gb|EFA07232.1| hypothetical protein TcasGA2_TC010589 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30045 BP_3 219.17 3.81 3064 91076900 XP_975025.1 1726 1.4e-189 PREDICTED: Y+L amino acid transporter 2 [Tribolium castaneum] 817087970 XM_012411364.1 77 2.17854e-29 PREDICTED: Athalia rosae Y+L amino acid transporter 2 (LOC105692280), transcript variant X4, mRNA K13872 SLC7A6 solute carrier family 7 (L-type amino acid transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13872 Q9UHI5 1043 9.3e-112 Large neutral amino acids transporter small subunit 2 OS=Homo sapiens GN=SLC7A8 PE=1 SV=1 PF01424//PF00324//PF13520//PF01990 R3H domain//Amino acid permease//Amino acid permease//ATP synthase (F/14-kDa) subunit GO:0003333//GO:0006865//GO:0055085//GO:0034220//GO:0006810 amino acid transmembrane transport//amino acid transport//transmembrane transport//ion transmembrane transport//transport GO:0003676//GO:0015171 nucleic acid binding//amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.30047 BP_3 11.21 0.35 1858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30048 BP_3 11.54 0.74 1044 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30050 BP_3 690.13 5.78 6045 642936704 XP_008198546.1 2616 1.8e-292 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P07207 158 7.7e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF00008//PF02793//PF13895 EGF-like domain//Hormone receptor domain//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016020 membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.30051 BP_3 46.00 1.08 2352 270004837 EFA01285.1 1617 4.8e-177 hypothetical protein TcasGA2_TC002917 [Tribolium castaneum] 751780154 XM_011200889.1 36 1.0324e-06 PREDICTED: Bactrocera dorsalis probable G-protein coupled receptor 139 (LOC105223237), mRNA -- -- -- -- Q8SWR3 1176 2.7e-127 Sex peptide receptor OS=Drosophila melanogaster GN=SPR PE=1 SV=1 PF00001//PF15491 7 transmembrane receptor (rhodopsin family)//CST, telomere maintenance, complex subunit CTC1 GO:0007186//GO:0000723 G-protein coupled receptor signaling pathway//telomere maintenance GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.30054 BP_3 321.00 9.57 1909 642935937 XP_008198237.1 1534 1.6e-167 PREDICTED: guanine nucleotide-binding protein subunit alpha homolog [Tribolium castaneum] -- -- -- -- -- K04346 GNA12 guanine nucleotide-binding protein subunit alpha-12 http://www.genome.jp/dbget-bin/www_bget?ko:K04346 P25157 1248 9.8e-136 Guanine nucleotide-binding protein subunit alpha homolog OS=Drosophila melanogaster GN=cta PE=2 SV=1 PF00503//PF00025//PF01580//PF04670//PF08477//PF01926 G-protein alpha subunit//ADP-ribosylation factor family//FtsK/SpoIIIE family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0031683//GO:0003677//GO:0005524//GO:0003924//GO:0019001//GO:0004871//GO:0000166//GO:0005525 G-protein beta/gamma-subunit complex binding//DNA binding//ATP binding//GTPase activity//guanyl nucleotide binding//signal transducer activity//nucleotide binding//GTP binding -- -- -- -- Cluster-8309.30056 BP_3 151.00 28.50 547 478254770 ENN75006.1 233 3.4e-17 hypothetical protein YQE_08323, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30057 BP_3 149.74 8.26 1165 -- -- -- -- -- 642917523 XM_008193017.1 66 1.05948e-23 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF03964 Chorion family 2 GO:0007275 multicellular organismal development -- -- GO:0042600 chorion -- -- Cluster-8309.30058 BP_3 10.67 0.50 1319 817193593 XP_012272264.1 146 1.0e-06 PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193595|ref|XP_012272265.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193597|ref|XP_012272266.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.30059 BP_3 204.35 1.53 6744 642928254 XP_008195509.1 3216 0.0e+00 PREDICTED: bifunctional glutamate/proline--tRNA ligase [Tribolium castaneum] 170063636 XM_001867153.1 194 4.40008e-94 Culex quinquefasciatus bifunctional aminoacyl-tRNA synthetase, mRNA K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 P28668 2719 9.3e-306 Bifunctional glutamate/proline--tRNA ligase OS=Drosophila melanogaster GN=Aats-glupro PE=1 SV=2 PF00992//PF00749//PF00587//PF02146//PF00458//PF09180//PF03012//PF03950 Troponin//tRNA synthetases class I (E and Q), catalytic domain//tRNA synthetase class II core domain (G, H, P, S and T)//Sir2 family//WHEP-TRS domain//Prolyl-tRNA synthetase, C-terminal//Phosphoprotein//tRNA synthetases class I (E and Q), anti-codon binding domain GO:0019083//GO:0006525//GO:0006433//GO:0006418//GO:0043039//GO:0006560//GO:0006144 viral transcription//arginine metabolic process//prolyl-tRNA aminoacylation//tRNA aminoacylation for protein translation//tRNA aminoacylation//proline metabolic process//purine nucleobase metabolic process GO:0000166//GO:0016876//GO:0004812//GO:0005524//GO:0004827//GO:0003968//GO:0070403 nucleotide binding//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity//ATP binding//proline-tRNA ligase activity//RNA-directed RNA polymerase activity//NAD+ binding GO:0005737//GO:0031379//GO:0005861 cytoplasm//RNA-directed RNA polymerase complex//troponin complex KOG4163 Prolyl-tRNA synthetase Cluster-8309.30061 BP_3 14.42 0.54 1574 91088179 XP_972438.1 1054 6.2e-112 PREDICTED: hydroxyacylglutathione hydrolase, mitochondrial [Tribolium castaneum]>gi|270012133|gb|EFA08581.1| hypothetical protein TcasGA2_TC006236 [Tribolium castaneum] -- -- -- -- -- K01069 E3.1.2.6, gloB hydroxyacylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01069 Q6P963 764 1.1e-79 Hydroxyacylglutathione hydrolase, mitochondrial OS=Danio rerio GN=hagh PE=2 SV=2 -- -- GO:0006750//GO:0006090 glutathione biosynthetic process//pyruvate metabolic process GO:0004416//GO:0008270 hydroxyacylglutathione hydrolase activity//zinc ion binding -- -- KOG0813 Glyoxylase Cluster-8309.30062 BP_3 703.70 21.63 1860 642910469 XP_008200226.1 1071 7.8e-114 PREDICTED: uncharacterized protein LOC659133 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZR8 242 4.3e-19 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.30065 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30069 BP_3 122.90 7.27 1107 478262394 ENN81065.1 271 2.7e-21 hypothetical protein YQE_02434, partial [Dendroctonus ponderosae]>gi|546673614|gb|ERL85178.1| hypothetical protein D910_02600 [Dendroctonus ponderosae] -- -- -- -- -- K16365 SGTA small glutamine-rich tetratricopeptide repeat-containing protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16365 O43765 144 5.9e-08 Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens GN=SGTA PE=1 SV=1 PF13414//PF00515 TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0553 TPR repeat-containing protein Cluster-8309.30072 BP_3 1143.79 19.02 3191 642917789 XP_008191287.1 901 6.9e-94 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1 [Tribolium castaneum] 403179775 XM_003338024.2 42 6.49236e-10 Puccinia graminis f. sp. tritici CRL 75-36-700-3 glucosamine-fructose-6-phosphate aminotransferase (PGTG_19602), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 P47856 629 9.9e-64 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Mus musculus GN=Gfpt1 PE=1 SV=3 PF11593 Mediator complex subunit 3 fungal GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.30073 BP_3 301.08 2.48 6154 642917793 XP_008191289.1 2136 8.3e-237 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X3 [Tribolium castaneum] 768412757 XM_011570168.1 425 0 PREDICTED: Plutella xylostella glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1-like (LOC105398114), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q4KMC4 1723 2.6e-190 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Rattus norvegicus GN=Gfpt2 PE=2 SV=3 PF11593//PF13580//PF01380 Mediator complex subunit 3 fungal//SIS domain//SIS domain GO:0005975//GO:0006357 carbohydrate metabolic process//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0030246 RNA polymerase II transcription cofactor activity//carbohydrate binding GO:0016592 mediator complex KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.30074 BP_3 1012.95 16.59 3234 642928365 XP_008192713.1 1314 9.0e-142 PREDICTED: uncharacterized protein LOC103312832 isoform X1 [Tribolium castaneum]>gi|270010785|gb|EFA07233.1| hypothetical protein TcasGA2_TC010590 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRJ8 423 7.7e-40 Protein Asterix OS=Drosophila melanogaster GN=CG10674 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3462 Predicted membrane protein Cluster-8309.30076 BP_3 377.37 4.17 4652 642928280 XP_008195517.1 1862 3.7e-205 PREDICTED: uncharacterized protein LOC658443 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12737 SDCCAG10 peptidyl-prolyl cis-trans isomerase SDCCAG10 http://www.genome.jp/dbget-bin/www_bget?ko:K12737 Q6UX04 644 2.6e-65 Peptidyl-prolyl cis-trans isomerase CWC27 homolog OS=Homo sapiens GN=CWC27 PE=1 SV=1 PF00160//PF02601 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Exonuclease VII, large subunit GO:0006457//GO:0006308//GO:0000413 protein folding//DNA catabolic process//protein peptidyl-prolyl isomerization GO:0003755//GO:0008855 peptidyl-prolyl cis-trans isomerase activity//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG0885 Peptidyl-prolyl cis-trans isomerase Cluster-8309.30077 BP_3 83.77 1.67 2704 642928762 XP_008199773.1 2901 0.0e+00 PREDICTED: nephrin [Tribolium castaneum] 642928761 XM_008201551.1 611 0 PREDICTED: Tribolium castaneum nephrin (LOC663236), mRNA -- -- -- -- Q8WZ42 241 8.2e-19 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF13895//PF04850//PF00041 Immunoglobulin domain//Baculovirus E66 occlusion-derived virus envelope protein//Fibronectin type III domain -- -- GO:0005515 protein binding GO:0019031 viral envelope -- -- Cluster-8309.30078 BP_3 521.19 11.14 2546 642927700 XP_008196611.1 1675 9.8e-184 PREDICTED: LOW QUALITY PROTEIN: oxidative stress-induced growth inhibitor 2-like [Tribolium castaneum] 642927699 XM_008198389.1 99 1.06478e-41 PREDICTED: Tribolium castaneum oxidative stress-induced growth inhibitor 2-like (LOC655536), mRNA -- -- -- -- Q9UJX0 433 4.2e-41 Oxidative stress-induced growth inhibitor 1 OS=Homo sapiens GN=OSGIN1 PE=1 SV=3 PF07992//PF01494//PF00070 Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491//GO:0071949 oxidoreductase activity//FAD binding -- -- -- -- Cluster-8309.30079 BP_3 86.72 1.27 3570 91083575 XP_968060.1 685 8.6e-69 PREDICTED: ribonuclease H2 subunit B [Tribolium castaneum]>gi|270007823|gb|EFA04271.1| hypothetical protein TcasGA2_TC014561 [Tribolium castaneum] -- -- -- -- -- K10744 RNASEH2B ribonuclease H2 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10744 Q28GD9 228 3.5e-17 Ribonuclease H2 subunit B OS=Xenopus tropicalis GN=rnaseh2b PE=2 SV=1 PF01786 Alternative oxidase GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009916 alternative oxidase activity GO:0005634 nucleus -- -- Cluster-8309.30083 BP_3 23.84 0.90 1571 589094703 AHK59785.1 521 3.9e-50 major facilitator superfamily protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.30087 BP_3 526.00 10.70 2661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30089 BP_3 108.16 1.02 5405 827548948 XP_012546635.1 2755 1.2e-308 PREDICTED: von Willebrand factor A domain-containing protein 8 [Bombyx mori] -- -- -- -- -- -- -- -- -- Q8CC88 2294 1.4e-256 von Willebrand factor A domain-containing protein 8 OS=Mus musculus GN=Vwa8 PE=2 SV=2 PF02562//PF00421//PF00004//PF00158//PF01926//PF07728//PF08477//PF01695//PF00910//PF00493//PF00006//PF01637//PF03193//PF07726//PF00005//PF07724//PF01443 PhoH-like protein//Photosystem II protein//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//IstB-like ATP binding protein//RNA helicase//MCM2/3/5 family//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//AAA domain (Cdc48 subfamily)//Viral (Superfamily 1) RNA helicase GO:0009767//GO:0007264//GO:0006355//GO:0006260//GO:0019684 photosynthetic electron transport chain//small GTPase mediated signal transduction//regulation of transcription, DNA-templated//DNA replication//photosynthesis, light reaction GO:0003723//GO:0003677//GO:0005525//GO:0003724//GO:0005524//GO:0016168//GO:0008134//GO:0003924//GO:0016887 RNA binding//DNA binding//GTP binding//RNA helicase activity//ATP binding//chlorophyll binding//transcription factor binding//GTPase activity//ATPase activity GO:0005667//GO:0016020//GO:0009521 transcription factor complex//membrane//photosystem KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.30090 BP_3 53.48 0.47 5806 91095331 XP_975275.1 3625 0.0e+00 PREDICTED: von Willebrand factor A domain-containing protein 8 [Tribolium castaneum]>gi|270017220|gb|EFA13666.1| hypothetical protein TcasGA2_TC004261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CC88 2294 1.5e-256 von Willebrand factor A domain-containing protein 8 OS=Mus musculus GN=Vwa8 PE=2 SV=2 PF08477//PF07728//PF01695//PF01926//PF00158//PF00421//PF00004//PF03193//PF07726//PF00005//PF00006//PF01637//PF00493//PF04670//PF00910//PF01443//PF07724 Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//50S ribosome-binding GTPase//Sigma-54 interaction domain//Photosystem II protein//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//MCM2/3/5 family//Gtr1/RagA G protein conserved region//RNA helicase//Viral (Superfamily 1) RNA helicase//AAA domain (Cdc48 subfamily) GO:0019684//GO:0006355//GO:0006260//GO:0007264//GO:0009767 photosynthesis, light reaction//regulation of transcription, DNA-templated//DNA replication//small GTPase mediated signal transduction//photosynthetic electron transport chain GO:0000166//GO:0016887//GO:0003924//GO:0008134//GO:0005524//GO:0016168//GO:0003724//GO:0017111//GO:0005525//GO:0003723//GO:0003677 nucleotide binding//ATPase activity//GTPase activity//transcription factor binding//ATP binding//chlorophyll binding//RNA helicase activity//nucleoside-triphosphatase activity//GTP binding//RNA binding//DNA binding GO:0009521//GO:0016020//GO:0005667 photosystem//membrane//transcription factor complex KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.30091 BP_3 218.10 1.11 9748 642928397 XP_008192729.1 3555 0.0e+00 PREDICTED: homeobox protein prospero isoform X3 [Tribolium castaneum] 642928396 XM_008194507.1 1300 0 PREDICTED: Tribolium castaneum homeobox protein prospero (LOC660328), transcript variant X4, mRNA -- -- -- -- P29617 965 3.3e-102 Homeobox protein prospero OS=Drosophila melanogaster GN=pros PE=1 SV=3 PF15556//PF13855//PF00560//PF05044 ZW10 interactor//Leucine rich repeat//Leucine Rich Repeat//Homeo-prospero domain GO:0007093 mitotic cell cycle checkpoint GO:0003677//GO:0005515 DNA binding//protein binding GO:0000776 kinetochore KOG3779 Homeobox transcription factor prospero Cluster-8309.30094 BP_3 10.74 0.77 964 91087357 XP_975625.1 742 5.7e-76 PREDICTED: ADP-ribosylation factor-like protein 2 [Tribolium castaneum]>gi|270010616|gb|EFA07064.1| hypothetical protein TcasGA2_TC010041 [Tribolium castaneum] -- -- -- -- -- K07943 ARL2 ADP-ribosylation factor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07943 P36404 659 9.9e-68 ADP-ribosylation factor-like protein 2 OS=Homo sapiens GN=ARL2 PE=1 SV=4 PF08477//PF00503//PF04670//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0031683//GO:0003924//GO:0005525//GO:0019001//GO:0004871 G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//guanyl nucleotide binding//signal transducer activity GO:0005622 intracellular KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2 Cluster-8309.30095 BP_3 102.00 8.19 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30097 BP_3 84.00 7.27 849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30098 BP_3 74.76 1.68 2431 478257402 ENN77558.1 757 2.6e-77 hypothetical protein YQE_05854, partial [Dendroctonus ponderosae] -- -- -- -- -- K17757 CARKD ATP-dependent NAD(P)H-hydrate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K17757 E3XDZ8 539 2.0e-53 ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Anopheles darlingi GN=AND_21715 PE=3 SV=1 PF01256 Carbohydrate kinase -- -- GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity -- -- KOG3974 Predicted sugar kinase Cluster-8309.30103 BP_3 2454.74 14.27 8585 642931063 XP_008196196.1 1688 1.0e-184 PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|642931065|ref|XP_008196197.1| PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|270011892|gb|EFA08340.1| hypothetical protein TcasGA2_TC005983 [Tribolium castaneum] 195484142 XM_002090535.1 90 3.6482e-36 Drosophila yakuba RpS26 (Dyak\RpS26), partial mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 Q9GT45 503 1.1e-48 40S ribosomal protein S26 OS=Anopheles gambiae GN=RpS26 PE=3 SV=2 PF15473//PF01283 PEST, proteolytic signal-containing nuclear protein family//Ribosomal protein S26e GO:0042254//GO:0016567//GO:0006412 ribosome biogenesis//protein ubiquitination//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1768 40s ribosomal protein S26 Cluster-8309.30104 BP_3 1124.31 4.45 12458 270006541 EFA02989.1 7387 0.0e+00 hypothetical protein TcasGA2_TC010408 [Tribolium castaneum] 642922985 XM_008202260.1 1251 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase TRIP12 (LOC658915), transcript variant X4, mRNA K10590 TRIP12 E3 ubiquitin-protein ligase TRIP12 http://www.genome.jp/dbget-bin/www_bget?ko:K10590 G5E870 4375 0.0e+00 E3 ubiquitin-protein ligase TRIP12 OS=Mus musculus GN=Trip12 PE=1 SV=1 PF13174//PF00632//PF00514//PF04049//PF12470//PF13181//PF13414//PF13176//PF13374//PF00515//PF13371 Tetratricopeptide repeat//HECT-domain (ubiquitin-transferase)//Armadillo/beta-catenin-like repeat//Anaphase promoting complex subunit 8 / Cdc23//Suppressor of Fused Gli/Ci N terminal binding domain//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0016567//GO:0030071 protein ubiquitination//regulation of mitotic metaphase/anaphase transition GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0170 E3 ubiquitin protein ligase Cluster-8309.30105 BP_3 39.53 0.33 5989 478257262 ENN77425.1 3529 0.0e+00 hypothetical protein YQE_06250, partial [Dendroctonus ponderosae]>gi|546683816|gb|ERL93569.1| hypothetical protein D910_10857 [Dendroctonus ponderosae] 801384853 XM_012200272.1 35 9.53713e-06 PREDICTED: Atta cephalotes tyrosine-protein phosphatase non-receptor type 23 (LOC105618741), mRNA K18040 PTPN23 tyrosine-protein phosphatase non-receptor type 23 http://www.genome.jp/dbget-bin/www_bget?ko:K18040 Q6PB44 1409 6.6e-154 Tyrosine-protein phosphatase non-receptor type 23 OS=Mus musculus GN=Ptpn23 PE=1 SV=2 PF00102//PF13949//PF15178//PF04632 Protein-tyrosine phosphatase//ALIX V-shaped domain binding to HIV//Mitochondrial import receptor subunit TOM5 homolog//Fusaric acid resistance protein family GO:0006570//GO:0006470//GO:0006810 tyrosine metabolic process//protein dephosphorylation//transport GO:0005515//GO:0004725 protein binding//protein tyrosine phosphatase activity GO:0005886//GO:0005742 plasma membrane//mitochondrial outer membrane translocase complex KOG2220 Predicted signal transduction protein Cluster-8309.30107 BP_3 12.98 97.74 251 642932342 XP_008197073.1 182 1.3e-11 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30108 BP_3 124.28 3.50 2005 270001371 EEZ97818.1 1190 1.3e-127 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914994 XM_008192253.1 391 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X5, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 O60506 769 3.6e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens GN=SYNCRIP PE=1 SV=2 PF16622//PF00076//PF16367 zinc-finger C2H2-type//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.30109 BP_3 105.00 6.38 1085 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30110 BP_3 45.49 1.03 2419 805784346 XP_012140054.1 374 6.7e-33 PREDICTED: DNA primase large subunit-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q84WJ2 220 2.0e-16 Probable DNA primase large subunit OS=Arabidopsis thaliana GN=At1g67320 PE=2 SV=2 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896 DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.30112 BP_3 838.98 24.28 1957 546686493 ERL95715.1 920 2.7e-96 hypothetical protein D910_00153 [Dendroctonus ponderosae]>gi|546687391|gb|ERL96116.1| hypothetical protein D910_01091 [Dendroctonus ponderosae] 665801637 XM_008550618.1 178 9.89258e-86 PREDICTED: Microplitis demolitor corepressor interacting with RBPJ 1 (LOC103572157), mRNA K06066 CIR CBF1 interacting corepressor http://www.genome.jp/dbget-bin/www_bget?ko:K06066 Q86X95 503 2.5e-49 Corepressor interacting with RBPJ 1 OS=Homo sapiens GN=CIR1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3794 CBF1-interacting corepressor CIR and related proteins Cluster-8309.30114 BP_3 268.44 8.69 1781 642933417 XP_008197409.1 1625 4.3e-178 PREDICTED: cytochrome P450 9e2-like [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1073 1.8e-115 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30115 BP_3 345.12 10.68 1850 642933417 XP_008197409.1 1607 5.5e-176 PREDICTED: cytochrome P450 9e2-like [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1081 2.2e-116 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30117 BP_3 555.95 3.32 8355 91082665 XP_971149.1 1312 4.0e-141 PREDICTED: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [Tribolium castaneum]>gi|270015048|gb|EFA11496.1| hypothetical protein TcasGA2_TC014209 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q920M9 1094 3.1e-117 E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 PE=1 SV=2 PF03145//PF02817//PF05191//PF00097//PF00198//PF02224 Seven in absentia protein family//e3 binding domain//Adenylate kinase, active site lid//Zinc finger, C3HC4 type (RING finger)//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Cytidylate kinase GO:0006511//GO:0006206//GO:0008152//GO:0007275//GO:0006144//GO:0046034//GO:0006139 ubiquitin-dependent protein catabolic process//pyrimidine nucleobase metabolic process//metabolic process//multicellular organismal development//purine nucleobase metabolic process//ATP metabolic process//nucleobase-containing compound metabolic process GO:0004127//GO:0004017//GO:0046872//GO:0005524//GO:0016746 cytidylate kinase activity//adenylate kinase activity//metal ion binding//ATP binding//transferase activity, transferring acyl groups GO:0005634 nucleus KOG0558 Dihydrolipoamide transacylase (alpha-keto acid dehydrogenase E2 subunit) Cluster-8309.30118 BP_3 40.05 0.47 4412 91092696 XP_971938.1 2316 8.0e-258 PREDICTED: trafficking protein particle complex subunit 8 [Tribolium castaneum]>gi|270014865|gb|EFA11313.1| hypothetical protein TcasGA2_TC010852 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2L5 1365 6.2e-149 Trafficking protein particle complex subunit 8 OS=Homo sapiens GN=TRAPPC8 PE=1 SV=2 PF02883//PF13181//PF00515//PF00377//PF13414 Adaptin C-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Prion/Doppel alpha-helical domain//TPR repeat GO:0051260//GO:0006886//GO:0016192 protein homooligomerization//intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030131//GO:0016020 clathrin adaptor complex//membrane KOG1938 Protein with predicted involvement in meiosis (GSG1) Cluster-8309.30120 BP_3 675.76 20.80 1858 189237581 XP_974946.2 1126 3.3e-120 PREDICTED: glypican-6 [Tribolium castaneum] -- -- -- -- -- K08110 GPC4 glypican 4 (K-glypican) http://www.genome.jp/dbget-bin/www_bget?ko:K08110 Q5RE54 627 9.8e-64 Glypican-6 OS=Pongo abelii GN=GPC6 PE=2 SV=1 PF01153 Glypican -- -- GO:0043395 heparan sulfate proteoglycan binding GO:0005578//GO:0016020 proteinaceous extracellular matrix//membrane KOG3821 Heparin sulfate cell surface proteoglycan Cluster-8309.30121 BP_3 1033.37 7.84 6641 91076250 XP_966964.1 1806 1.6e-198 PREDICTED: testican-2 [Tribolium castaneum] 642912114 XM_961871.3 78 1.32064e-29 PREDICTED: Tribolium castaneum testican-2 (LOC655329), mRNA -- -- -- -- Q9ER58 343 3.0e-30 Testican-2 OS=Mus musculus GN=Spock2 PE=2 SV=1 PF15009//PF07648//PF08527//PF00050//PF13833//PF00036//PF10591 Transmembrane protein 173//Kazal-type serine protease inhibitor domain//Protein-arginine deiminase (PAD) middle domain//Kazal-type serine protease inhibitor domain//EF-hand domain pair//EF hand//Secreted protein acidic and rich in cysteine Ca binding region GO:0007165//GO:0018101//GO:0002218//GO:0006807//GO:0032481 signal transduction//protein citrullination//activation of innate immune response//nitrogen compound metabolic process//positive regulation of type I interferon production GO:0005515//GO:0005509//GO:0004668 protein binding//calcium ion binding//protein-arginine deiminase activity GO:0005578//GO:0005737 proteinaceous extracellular matrix//cytoplasm KOG3555 Ca2+-binding proteoglycan Testican Cluster-8309.30125 BP_3 307.28 8.29 2079 478255293 ENN75519.1 1572 7.0e-172 hypothetical protein YQE_07863, partial [Dendroctonus ponderosae]>gi|546683153|gb|ERL93004.1| hypothetical protein D910_10306 [Dendroctonus ponderosae] 820848257 XM_012486488.1 41 1.51327e-09 PREDICTED: Apis florea PAB-dependent poly(A)-specific ribonuclease subunit PAN3 (LOC100865909), transcript variant X4, mRNA K12572 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12572 Q95RR8 1019 3.8e-109 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Drosophila melanogaster GN=CG11486 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG3741 Poly(A) ribonuclease subunit Cluster-8309.30126 BP_3 3.00 0.54 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30127 BP_3 119.00 7.31 1076 91080531 XP_966681.1 1492 6.9e-163 PREDICTED: protein mab-21 [Tribolium castaneum]>gi|270005805|gb|EFA02253.1| hypothetical protein TcasGA2_TC007916 [Tribolium castaneum] 805787052 XM_003703263.2 308 2.90374e-158 PREDICTED: Megachile rotundata protein mab-21 (LOC100883216), mRNA -- -- -- -- Q5TW90 1384 9.4e-152 Protein mab-21 OS=Anopheles gambiae GN=mab-21 PE=3 SV=3 -- -- GO:0045165 cell fate commitment -- -- -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.30130 BP_3 105.00 7.20 995 478254655 ENN74896.1 171 9.6e-10 hypothetical protein YQE_08474, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02133//PF05454//PF00335 Permease for cytosine/purines, uracil, thiamine, allantoin//Dystroglycan (Dystrophin-associated glycoprotein 1)//Tetraspanin family GO:0007016//GO:0055085//GO:0006810 cytoskeletal anchoring at plasma membrane//transmembrane transport//transport GO:0005215 transporter activity GO:0016021//GO:0016010//GO:0016020 integral component of membrane//dystrophin-associated glycoprotein complex//membrane -- -- Cluster-8309.30131 BP_3 264.52 4.20 3327 642910948 XP_008193477.1 3019 0.0e+00 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 2124 4.5e-237 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF00326//PF02897 Prolyl oligopeptidase family//Prolyl oligopeptidase, N-terminal beta-propeller domain GO:0006508 proteolysis GO:0070008//GO:0004252//GO:0008236 serine-type exopeptidase activity//serine-type endopeptidase activity//serine-type peptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.30132 BP_3 51.06 0.64 4113 642910948 XP_008193477.1 1972 5.8e-218 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 1403 2.3e-153 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF00326//PF02897 Prolyl oligopeptidase family//Prolyl oligopeptidase, N-terminal beta-propeller domain GO:0006508 proteolysis GO:0008236//GO:0004252//GO:0070008 serine-type peptidase activity//serine-type endopeptidase activity//serine-type exopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.30134 BP_3 147.00 3.04 2619 -- -- -- -- -- 642929258 XM_008197536.1 81 1.11135e-31 PREDICTED: Tribolium castaneum translin (LOC103313671), mRNA -- -- -- -- -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- -- -- Cluster-8309.30136 BP_3 25.00 7.69 448 642915333 XP_008190576.1 137 3.8e-06 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30138 BP_3 96.00 9.05 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30140 BP_3 100.59 1.13 4589 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.63133e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 2.0e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186//PF00278 Vacuolar sorting 38 and autophagy-related subunit 14//Pyridoxal-dependent decarboxylase, C-terminal sheet domain GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.30145 BP_3 51.19 1.54 1894 642923143 XP_008193628.1 241 1.4e-17 PREDICTED: nuclear receptor coactivator 3 isoform X7 [Tribolium castaneum] 642923146 XM_008195408.1 242 2.53181e-121 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30146 BP_3 72.75 0.89 4232 642938764 XP_008199878.1 658 1.4e-65 PREDICTED: uncharacterized protein LOC656472 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30147 BP_3 366.27 9.69 2113 642921500 XP_001811085.2 1096 1.1e-116 PREDICTED: venom acid phosphatase Acph-1-like [Tribolium castaneum]>gi|270006248|gb|EFA02696.1| hypothetical protein TcasGA2_TC008418 [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q5BLY5 645 9.1e-66 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.30148 BP_3 44.64 0.60 3904 642930728 XP_008200003.1 1104 2.4e-117 PREDICTED: sorting nexin-8 [Tribolium castaneum] -- -- -- -- -- K17922 SNX8, MVP1 sorting nexin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K17922 Q2KHV6 543 1.1e-53 Sorting nexin-8 OS=Bos taurus GN=SNX8 PE=2 SV=1 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- -- -- Cluster-8309.30150 BP_3 791.61 13.57 3104 91082031 XP_970514.1 1373 1.2e-148 PREDICTED: elongation of very long chain fatty acids protein 6 [Tribolium castaneum]>gi|270007304|gb|EFA03752.1| hypothetical protein TcasGA2_TC013861 [Tribolium castaneum] 642921969 XM_965421.3 282 2.42658e-143 PREDICTED: Tribolium castaneum elongation of very long chain fatty acids protein 6 (LOC659089), mRNA K10203 ELOVL6 elongation of very long chain fatty acids protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10203 Q5ZJR8 682 6.9e-70 Elongation of very long chain fatty acids protein 6 OS=Gallus gallus GN=ELOVL6 PE=2 SV=1 PF08273//PF01151 Zinc-binding domain of primase-helicase//GNS1/SUR4 family GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0008270//GO:0003896//GO:0004386 zinc ion binding//DNA primase activity//helicase activity GO:0005730//GO:0005657//GO:0016021 nucleolus//replication fork//integral component of membrane KOG3072 Long chain fatty acid elongase Cluster-8309.30154 BP_3 43.04 0.81 2853 557332086 XP_006038864.1 379 2.1e-33 PREDICTED: zinc finger protein 850-like [Alligator sinensis] -- -- -- -- -- K09229 ZKSCAN KRAB and SCAN domains-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09229 Q9EQB9 365 3.6e-33 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF07975//PF13465//PF02701//PF16622//PF02892//PF13912//PF01155//PF02772//PF00096 TFIIH C1-like domain//Zinc-finger double domain//Dof domain, zinc finger//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//S-adenosylmethionine synthetase, central domain//Zinc finger, C2H2 type GO:0006464//GO:0006281//GO:0006355//GO:0006556//GO:0006555 cellular protein modification process//DNA repair//regulation of transcription, DNA-templated//S-adenosylmethionine biosynthetic process//methionine metabolic process GO:0003677//GO:0004478//GO:0016151//GO:0008270//GO:0046872 DNA binding//methionine adenosyltransferase activity//nickel cation binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.30156 BP_3 23.17 1.14 1273 91086137 XP_968906.1 154 1.1e-07 PREDICTED: sister chromatid cohesion protein PDS5 homolog B isoform X1 [Tribolium castaneum]>gi|270010223|gb|EFA06671.1| hypothetical protein TcasGA2_TC009599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30157 BP_3 16.83 0.51 1893 332374148 AEE62215.1 1067 2.3e-113 unknown [Dendroctonus ponderosae]>gi|546676817|gb|ERL87763.1| hypothetical protein D910_05152 [Dendroctonus ponderosae] -- -- -- -- -- K17885 MTCH mitochondrial carrier http://www.genome.jp/dbget-bin/www_bget?ko:K17885 Q791V5 591 1.5e-59 Mitochondrial carrier homolog 2 OS=Mus musculus GN=Mtch2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2745 Mitochondrial carrier protein Cluster-8309.30161 BP_3 1169.00 30.50 2139 568253343 ETN62507.1 1616 5.7e-177 GTP-binding protein alpha subunit, gna [Anopheles darlingi] 662190831 XM_008469977.1 185 1.39099e-89 PREDICTED: Diaphorina citri guanine nucleotide-binding protein G(s) subunit alpha (LOC103505624), mRNA K04632 GNAS guanine nucleotide-binding protein G(s) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04632 Q7PD79 1612 6.8e-178 Guanine nucleotide-binding protein G(s) subunit alpha OS=Anopheles gambiae GN=G-s-alpha-60A PE=2 SV=1 PF04670//PF00025//PF00503//PF08477 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//G-protein alpha subunit//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0031683//GO:0003924//GO:0005525//GO:0004871//GO:0019001 G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0099 G protein subunit Galphas, small G protein superfamily Cluster-8309.30162 BP_3 334.73 13.41 1495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30164 BP_3 315.32 3.65 4452 221115973 XP_002165005.1 1003 1.4e-105 PREDICTED: uncharacterized protein LOC100209733 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- Q52V16 273 2.6e-22 Zinc finger Y-chromosomal protein OS=Gorilla gorilla gorilla GN=ZFY PE=3 SV=1 PF02150//PF06397//PF00096//PF13465//PF03184 RNA polymerases M/15 Kd subunit//Desulfoferrodoxin, N-terminal domain//Zinc finger, C2H2 type//Zinc-finger double domain//DDE superfamily endonuclease GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0003676//GO:0005506//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//nucleic acid binding//iron ion binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.30166 BP_3 138.92 4.40 1812 91093218 XP_967029.1 379 1.3e-33 PREDICTED: GTP cyclohydrolase 1 isoform X1 [Tribolium castaneum]>gi|270016588|gb|EFA13034.1| hypothetical protein TcasGA2_TC010564 [Tribolium castaneum] 241989293 AK336271.1 118 2.06566e-52 Triticum aestivum cDNA, clone: SET3_K11, cultivar: Chinese Spring -- -- -- -- P48596 277 3.7e-23 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2698 GTP cyclohydrolase I Cluster-8309.30168 BP_3 470.86 30.37 1039 270010086 EFA06534.1 506 1.4e-48 hypothetical protein TcasGA2_TC009438 [Tribolium castaneum] 312094587 XM_003148025.1 56 3.41417e-18 Loa loa 40S ribosomal protein S11 (LOAG_12512) mRNA, complete cds K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P62282 485 1.6e-47 40S ribosomal protein S11 OS=Rattus norvegicus GN=Rps11 PE=1 SV=3 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.30170 BP_3 222.65 1.53 7327 332375100 AEE62691.1 2046 2.7e-226 unknown [Dendroctonus ponderosae] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 1064 8.2e-114 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF01695//PF00005//PF03193//PF01061//PF13304//PF01926//PF08031 IstB-like ATP binding protein//ABC transporter//Protein of unknown function, DUF258//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Berberine and berberine like GO:0055114 oxidation-reduction process GO:0005524//GO:0003924//GO:0016491//GO:0016887//GO:0050660//GO:0005525 ATP binding//GTPase activity//oxidoreductase activity//ATPase activity//flavin adenine dinucleotide binding//GTP binding GO:0016020 membrane -- -- Cluster-8309.30173 BP_3 84.18 0.54 7806 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 9.3e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF01926//PF08477//PF03193//PF03810//PF00071//PF02421 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Importin-beta N-terminal domain//Ras family//Ferrous iron transport protein B GO:0015684//GO:0015031//GO:0007264//GO:0006886 ferrous iron transport//protein transport//small GTPase mediated signal transduction//intracellular protein transport GO:0008565//GO:0005525//GO:0015093//GO:0003924//GO:0008536 protein transporter activity//GTP binding//ferrous iron transmembrane transporter activity//GTPase activity//Ran GTPase binding GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.30174 BP_3 781.17 24.15 1851 642910658 XP_008200046.1 2157 9.1e-240 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7TMY8 1827 6.9e-203 E3 ubiquitin-protein ligase HUWE1 OS=Mus musculus GN=Huwe1 PE=1 SV=5 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30175 BP_3 789.35 3.35 11655 642910658 XP_008200046.1 10432 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3569 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30176 BP_3 69.39 1.79 2159 642910658 XP_008200046.1 1974 1.8e-218 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 1692 3.7e-187 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30178 BP_3 128.28 0.53 11947 642910658 XP_008200046.1 8538 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30179 BP_3 210.86 2.69 4071 91090296 XP_971651.1 1831 1.3e-201 PREDICTED: nitric oxide-associated protein 1 [Tribolium castaneum]>gi|270013800|gb|EFA10248.1| hypothetical protein TcasGA2_TC012448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NC60 908 5.6e-96 Nitric oxide-associated protein 1 OS=Homo sapiens GN=NOA1 PE=1 SV=2 PF08477//PF03193//PF01926//PF07817//PF00071//PF02421 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//GLE1-like protein//Ras family//Ferrous iron transport protein B GO:0007264//GO:0015684//GO:0016973 small GTPase mediated signal transduction//ferrous iron transport//poly(A)+ mRNA export from nucleus GO:0005525//GO:0003924//GO:0015093 GTP binding//GTPase activity//ferrous iron transmembrane transporter activity GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.30180 BP_3 485.57 6.33 3989 478259301 ENN79203.1 377 5.0e-33 hypothetical protein YQE_04387, partial [Dendroctonus ponderosae]>gi|546681743|gb|ERL91775.1| hypothetical protein D910_09101 [Dendroctonus ponderosae] 642935837 XM_964044.3 107 5.98452e-46 PREDICTED: Tribolium castaneum transmembrane protein 47 (LOC657593), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG4671 Brain cell membrane protein 1 (BCMP1) Cluster-8309.30181 BP_3 479.15 4.92 4982 189241194 XP_969137.2 697 4.9e-70 PREDICTED: transmembrane protein 47 [Tribolium castaneum] 642935837 XM_964044.3 167 3.31543e-79 PREDICTED: Tribolium castaneum transmembrane protein 47 (LOC657593), mRNA -- -- -- -- -- -- -- -- PF00517//PF00822//PF00957//PF13903 Retroviral envelope protein//PMP-22/EMP/MP20/Claudin family//Synaptobrevin//PMP-22/EMP/MP20/Claudin tight junction GO:0016192 vesicle-mediated transport GO:0005198 structural molecule activity GO:0016021//GO:0019031 integral component of membrane//viral envelope KOG4671 Brain cell membrane protein 1 (BCMP1) Cluster-8309.30182 BP_3 1465.05 15.40 4877 270013966 EFA10414.1 684 1.5e-68 hypothetical protein TcasGA2_TC012654 [Tribolium castaneum] 642935837 XM_964044.3 164 1.50977e-77 PREDICTED: Tribolium castaneum transmembrane protein 47 (LOC657593), mRNA -- -- -- -- -- -- -- -- PF00517//PF06687//PF13903//PF06072//PF00957//PF00822 Retroviral envelope protein//SUR7/PalI family//PMP-22/EMP/MP20/Claudin tight junction//Alphaherpesvirus tegument protein US9//Synaptobrevin//PMP-22/EMP/MP20/Claudin family GO:0016192 vesicle-mediated transport GO:0005198 structural molecule activity GO:0005886//GO:0016021//GO:0019033//GO:0019031 plasma membrane//integral component of membrane//viral tegument//viral envelope KOG4671 Brain cell membrane protein 1 (BCMP1) Cluster-8309.30183 BP_3 200.18 2.01 5090 646719272 KDR21444.1 638 3.5e-63 hypothetical protein L798_04146 [Zootermopsis nevadensis] 642935837 XM_964044.3 166 1.21848e-78 PREDICTED: Tribolium castaneum transmembrane protein 47 (LOC657593), mRNA -- -- -- -- -- -- -- -- PF00517//PF00822//PF13903 Retroviral envelope protein//PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction -- -- GO:0005198 structural molecule activity GO:0016021//GO:0019031 integral component of membrane//viral envelope KOG4671 Brain cell membrane protein 1 (BCMP1) Cluster-8309.30185 BP_3 263.35 2.09 6363 642934045 XP_008197618.1 1078 4.1e-114 PREDICTED: kelch-like protein 38 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 237 5.6e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF01344//PF00023//PF01370//PF00651//PF07992//PF07646//PF13606 Kelch motif//Ankyrin repeat//NAD dependent epimerase/dehydratase family//BTB/POZ domain//Pyridine nucleotide-disulphide oxidoreductase//Kelch motif//Ankyrin repeat GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0003824//GO:0050662 oxidoreductase activity//protein binding//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.30186 BP_3 248.98 4.42 3007 642917749 XP_008191355.1 3019 0.0e+00 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q179T2 933 5.2e-99 Exonuclease mut-7 homolog OS=Aedes aegypti GN=AAEL005527 PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- KOG4373 Predicted 3'-5' exonuclease Cluster-8309.30189 BP_3 39.39 2.89 948 100811805 BAE94685.1 1081 2.8e-115 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 402 6.1e-38 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00740//PF00326//PF07859 Parvovirus coat protein VP2//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0005198//GO:0016787 serine-type peptidase activity//structural molecule activity//hydrolase activity GO:0019028 viral capsid -- -- Cluster-8309.30190 BP_3 174.96 3.07 3040 642913836 XP_001815393.2 1519 1.4e-165 PREDICTED: engulfment and cell motility protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92556 411 1.8e-38 Engulfment and cell motility protein 1 OS=Homo sapiens GN=ELMO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30192 BP_3 8.90 0.35 1505 546681897 ERL91906.1 877 2.0e-91 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 468 2.2e-45 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.30196 BP_3 1134.11 10.37 5562 642924920 XP_008194097.1 1312 2.6e-141 PREDICTED: microtubule-associated protein futsch isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMF0 209 8.7e-15 Cordon-bleu protein-like 1 OS=Mus musculus GN=Cobll1 PE=1 SV=2 PF02205//PF02196 WH2 motif//Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057//GO:0003779 receptor signaling protein activity//actin binding -- -- -- -- Cluster-8309.302 BP_3 13.63 0.37 2048 766932491 XP_011498465.1 280 4.5e-22 PREDICTED: probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014//PF01607 Kunitz/Bovine pancreatic trypsin inhibitor domain//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0004867//GO:0008061 serine-type endopeptidase inhibitor activity//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.30201 BP_3 40.68 0.78 2800 91084625 XP_974579.1 1191 1.4e-127 PREDICTED: cullin-2 [Tribolium castaneum]>gi|270008911|gb|EFA05359.1| hypothetical protein TcasGA2_TC015524 [Tribolium castaneum] -- -- -- -- -- K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 638 7.8e-65 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2284 E3 ubiquitin ligase, Cullin 2 component Cluster-8309.30204 BP_3 1480.69 9.35 7924 546681997 ERL91993.1 4107 0.0e+00 hypothetical protein D910_09315 [Dendroctonus ponderosae] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 2242 2.2e-250 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF09026//PF05456//PF06701 Centromere protein B dimerisation domain//Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Mib_herc2 GO:0016567//GO:0045947//GO:0006355 protein ubiquitination//negative regulation of translational initiation//regulation of transcription, DNA-templated GO:0004842//GO:0003677//GO:0008190//GO:0003682//GO:0046872 ubiquitin-protein transferase activity//DNA binding//eukaryotic initiation factor 4E binding//chromatin binding//metal ion binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region KOG4276 Predicted hormone receptor interactor Cluster-8309.30206 BP_3 26.00 5.35 526 -- -- -- -- -- 697086957 XM_009658096.1 508 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.30207 BP_3 104.64 0.68 7714 861506711 XP_012924037.1 689 6.4e-69 PREDICTED: zinc finger protein 227 isoform X5 [Heterocephalus glaber] 297723644 NM_001187257.1 43 4.39098e-10 Oryza sativa Japonica Group Os05g0117798 (Os05g0117798) mRNA, complete cds K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q14590 681 2.2e-69 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF13465//PF07975//PF13912//PF01428//PF00225//PF16622//PF00096//PF05531//PF06467//PF07776 Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//AN1-like Zinc finger//Kinesin motor domain//zinc-finger C2H2-type//Zinc finger, C2H2 type//Nucleopolyhedrovirus P10 protein//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD) GO:0007017//GO:0006281//GO:0007018 microtubule-based process//DNA repair//microtubule-based movement GO:0046872//GO:0008270//GO:0008017//GO:0003777//GO:0005524 metal ion binding//zinc ion binding//microtubule binding//microtubule motor activity//ATP binding GO:0005874//GO:0045298//GO:0005634//GO:0019028 microtubule//tubulin complex//nucleus//viral capsid -- -- Cluster-8309.30208 BP_3 566.65 2.78 10111 642933099 XP_973043.3 2910 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.2e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF14572//PF08587 Phosphoribosyl transferase domain//Phosphoribosyl synthetase-associated domain//Ubiquitin associated domain (UBA) GO:0009116//GO:0009069//GO:0006144//GO:0009165//GO:0016310//GO:0006098 nucleoside metabolic process//serine family amino acid metabolic process//purine nucleobase metabolic process//nucleotide biosynthetic process//phosphorylation//pentose-phosphate shunt GO:0004749//GO:0000287//GO:0004674 ribose phosphate diphosphokinase activity//magnesium ion binding//protein serine/threonine kinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.30211 BP_3 620.76 2.73 11237 642933099 XP_973043.3 3459 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.3e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF08587//PF14572//PF00076 Phosphoribosyl transferase domain//Ubiquitin associated domain (UBA)//Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0009116//GO:0006144//GO:0009069//GO:0009165//GO:0016310//GO:0006098 nucleoside metabolic process//purine nucleobase metabolic process//serine family amino acid metabolic process//nucleotide biosynthetic process//phosphorylation//pentose-phosphate shunt GO:0004749//GO:0004674//GO:0000287//GO:0003676 ribose phosphate diphosphokinase activity//protein serine/threonine kinase activity//magnesium ion binding//nucleic acid binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.30212 BP_3 741.01 3.08 11893 642933099 XP_973043.3 2380 8.2e-265 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA -- -- -- -- Q5ZL26 1288 1.4e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF08587//PF00076//PF14572//PF00156 Ubiquitin associated domain (UBA)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Phosphoribosyl synthetase-associated domain//Phosphoribosyl transferase domain GO:0009116//GO:0016310//GO:0009165//GO:0009069//GO:0006144//GO:0006098 nucleoside metabolic process//phosphorylation//nucleotide biosynthetic process//serine family amino acid metabolic process//purine nucleobase metabolic process//pentose-phosphate shunt GO:0000287//GO:0004674//GO:0004749//GO:0003676 magnesium ion binding//protein serine/threonine kinase activity//ribose phosphate diphosphokinase activity//nucleic acid binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.30213 BP_3 275.04 1.17 11659 642933099 XP_973043.3 2372 6.8e-264 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA -- -- -- -- Q5ZL26 1288 1.4e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF14572//PF00076//PF08587//PF00156 Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ubiquitin associated domain (UBA)//Phosphoribosyl transferase domain GO:0016310//GO:0009165//GO:0009069//GO:0006144//GO:0006098//GO:0009116 phosphorylation//nucleotide biosynthetic process//serine family amino acid metabolic process//purine nucleobase metabolic process//pentose-phosphate shunt//nucleoside metabolic process GO:0000287//GO:0004674//GO:0004749//GO:0003676 magnesium ion binding//protein serine/threonine kinase activity//ribose phosphate diphosphokinase activity//nucleic acid binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.30215 BP_3 2637.57 81.37 1854 91077396 XP_975299.1 2446 2.8e-273 PREDICTED: T-complex protein 1 subunit theta [Tribolium castaneum]>gi|270002115|gb|EEZ98562.1| hypothetical protein TcasGA2_TC001073 [Tribolium castaneum] -- -- -- -- -- K09500 CCT8 T-complex protein 1 subunit theta http://www.genome.jp/dbget-bin/www_bget?ko:K09500 Q6EE31 1813 2.9e-201 T-complex protein 1 subunit theta OS=Gallus gallus GN=CCT8 PE=1 SV=3 PF00118//PF06389 TCP-1/cpn60 chaperonin family//Filovirus membrane-associated protein VP24 GO:0006457//GO:0016032 protein folding//viral process GO:0005198//GO:0005524//GO:0051082 structural molecule activity//ATP binding//unfolded protein binding GO:0005737//GO:0016020 cytoplasm//membrane KOG0362 Chaperonin complex component, TCP-1 theta subunit (CCT8) Cluster-8309.30216 BP_3 118.96 4.64 1527 91091700 XP_972740.1 779 4.6e-80 PREDICTED: mannosyl-oligosaccharide glucosidase [Tribolium castaneum]>gi|270001063|gb|EEZ97510.1| hypothetical protein TcasGA2_TC011354 [Tribolium castaneum] -- -- -- -- -- K01228 GCS1 mannosyl-oligosaccharide glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01228 Q13724 349 1.4e-31 Mannosyl-oligosaccharide glucosidase OS=Homo sapiens GN=MOGS PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2161 Glucosidase I Cluster-8309.30218 BP_3 838.12 33.71 1490 189235746 XP_967247.2 727 4.8e-74 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 395 6.3e-37 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137 Adenosine-deaminase (editase) domain GO:0006396//GO:0006144//GO:0006807 RNA processing//purine nucleobase metabolic process//nitrogen compound metabolic process GO:0004000//GO:0003723 adenosine deaminase activity//RNA binding -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.30219 BP_3 1995.49 90.12 1359 91082701 XP_971906.1 1077 1.1e-114 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] 332375702 BT128031.1 171 5.30546e-82 Dendroctonus ponderosae clone DPO089_M20 unknown mRNA -- -- -- -- O15126 498 6.5e-49 Secretory carrier-associated membrane protein 1 OS=Homo sapiens GN=SCAMP1 PE=1 SV=2 PF04144//PF00049 SCAMP family//Insulin/IGF/Relaxin family GO:0007165//GO:0015031 signal transduction//protein transport GO:0005179 hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3088 Secretory carrier membrane protein Cluster-8309.30220 BP_3 37.75 1.52 1488 91082701 XP_971906.1 687 2.1e-69 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] 332375702 BT128031.1 143 2.13902e-66 Dendroctonus ponderosae clone DPO089_M20 unknown mRNA -- -- -- -- O15126 337 3.3e-30 Secretory carrier-associated membrane protein 1 OS=Homo sapiens GN=SCAMP1 PE=1 SV=2 PF00049//PF04144 Insulin/IGF/Relaxin family//SCAMP family GO:0015031//GO:0007165 protein transport//signal transduction GO:0005179 hormone activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG3088 Secretory carrier membrane protein Cluster-8309.30221 BP_3 30.47 2.22 953 91082701 XP_971906.1 216 5.6e-15 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28F21 162 4.2e-10 Secretory carrier-associated membrane protein 5 OS=Xenopus tropicalis GN=scamp5 PE=2 SV=1 PF04144 SCAMP family GO:0015031 protein transport -- -- GO:0016021 integral component of membrane KOG3088 Secretory carrier membrane protein Cluster-8309.30222 BP_3 37.74 0.38 5042 91086147 XP_969343.1 2917 0.0e+00 PREDICTED: integrator complex subunit 11 [Tribolium castaneum]>gi|270009886|gb|EFA06334.1| hypothetical protein TcasGA2_TC009205 [Tribolium castaneum] 826440986 XM_012674849.1 377 0 PREDICTED: Monomorium pharaonis integrator complex subunit 11 (LOC105833262), transcript variant X4, mRNA K13148 CPSF3L, INTS11 integrator complex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13148 Q5ZIH0 2284 1.9e-255 Integrator complex subunit 11 OS=Gallus gallus GN=CPSF3L PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.30225 BP_3 506.31 3.02 8363 642930342 XP_008196356.1 4733 0.0e+00 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 986 0 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- P35580 408 1.1e-37 Myosin-10 OS=Homo sapiens GN=MYH10 PE=1 SV=3 PF08702//PF02183//PF10473//PF07989//PF09730//PF10174//PF05550//PF05531//PF06156//PF04111//PF04048 Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Microtubule-associated protein Bicaudal-D//RIM-binding protein of the cytomatrix active zone//Pestivirus Npro endopeptidase C53//Nucleopolyhedrovirus P10 protein//Protein of unknown function (DUF972)//Autophagy protein Apg6//Sec8 exocyst complex component specific domain GO:0007165//GO:0051258//GO:0006914//GO:0006810//GO:0019082//GO:0006355//GO:0006260//GO:0015031//GO:0016032//GO:0006904//GO:0030168 signal transduction//protein polymerization//autophagy//transport//viral protein processing//regulation of transcription, DNA-templated//DNA replication//protein transport//viral process//vesicle docking involved in exocytosis//platelet activation GO:0008134//GO:0045502//GO:0043565//GO:0005102//GO:0003700//GO:0030674//GO:0042803 transcription factor binding//dynein binding//sequence-specific DNA binding//receptor binding//transcription factor activity, sequence-specific DNA binding//protein binding, bridging//protein homodimerization activity GO:0005815//GO:0019028//GO:0005794//GO:0048786//GO:0005577//GO:0030286//GO:0005667//GO:0000145 microtubule organizing center//viral capsid//Golgi apparatus//presynaptic active zone//fibrinogen complex//dynein complex//transcription factor complex//exocyst -- -- Cluster-8309.30226 BP_3 28.00 2.31 877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30227 BP_3 58.63 0.56 5351 642918584 XP_966986.2 1643 1.1e-179 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVD5 252 8.6e-20 Leucine-rich repeat-containing G-protein coupled receptor 6 OS=Mus musculus GN=Lgr6 PE=2 SV=1 PF07926//PF00560//PF16331//PF04977//PF13855//PF06005//PF10392 TPR/MLP1/MLP2-like protein//Leucine Rich Repeat//TolA binding protein trimerisation//Septum formation initiator//Leucine rich repeat//Protein of unknown function (DUF904)//Golgi transport complex subunit 5 GO:0006606//GO:0007049//GO:0000917//GO:0043093//GO:0006891//GO:0070206 protein import into nucleus//cell cycle//barrier septum assembly//FtsZ-dependent cytokinesis//intra-Golgi vesicle-mediated transport//protein trimerization GO:0005515 protein binding GO:0017119//GO:0005737 Golgi transport complex//cytoplasm KOG0619 FOG: Leucine rich repeat Cluster-8309.30230 BP_3 30.47 0.87 1977 642936794 XP_008199618.1 252 7.7e-19 PREDICTED: protein kish-A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWH8 231 8.7e-18 Protein kish OS=Drosophila melanogaster GN=ksh PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30231 BP_3 127.00 9.11 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30233 BP_3 33.00 1.16 1661 91076616 XP_969309.1 1481 2.0e-161 PREDICTED: uncharacterized protein LOC657780 [Tribolium castaneum]>gi|270002630|gb|EEZ99077.1| hypothetical protein TcasGA2_TC004956 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30234 BP_3 126.88 0.99 6486 189240413 XP_969795.2 2244 2.6e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.34924e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.4e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00498//PF00250 FHA domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0005515 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.30235 BP_3 115.90 0.89 6553 189240413 XP_969795.2 2244 2.6e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.36326e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.4e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00250//PF00498 Forkhead domain//FHA domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0005515//GO:0003700 sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.30239 BP_3 90.94 1.88 2621 242018392 XP_002429661.1 645 2.7e-64 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 529 3.2e-52 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.30240 BP_3 11.00 0.35 1817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30241 BP_3 290.04 2.05 7112 642931401 XP_008196564.1 7544 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 [Tribolium castaneum] 170051315 XM_001861674.1 59 5.16114e-19 Culex quinquefasciatus BIG3, mRNA K17572 ARFGEF3, KEPI brefeldin A-inhibited guanine nucleotide-exchange protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17572 Q3UGY8 1258 2.5e-136 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Mus musculus GN=Arfgef3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0929 Guanine nucleotide exchange factor Cluster-8309.30244 BP_3 23.24 0.80 1690 546685590 ERL95077.1 1823 4.5e-201 hypothetical protein D910_12347 [Dendroctonus ponderosae] 347969081 XM_003436308.1 562 0 Anopheles gambiae str. PEST AGAP003021-PB (AgaP_AGAP003021) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 1626 1.3e-179 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF09268//PF00637 Clathrin, heavy-chain linker//Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198 structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.30246 BP_3 7.00 0.61 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30247 BP_3 105.00 5.33 1241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17097 Spindle pole body component -- -- -- -- GO:0000775 chromosome, centromeric region -- -- Cluster-8309.30248 BP_3 284.28 3.66 4032 189240877 XP_971050.2 855 1.9e-88 PREDICTED: leucine-rich repeat flightless-interacting protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4V7E8 407 6.9e-38 Leucine-rich repeat flightless-interacting protein 2 OS=Rattus norvegicus GN=Lrrfip2 PE=2 SV=1 PF05557//PF00769 Mitotic checkpoint protein//Ezrin/radixin/moesin family GO:0007094 mitotic spindle assembly checkpoint GO:0008092 cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane KOG2010 Double stranded RNA binding protein Cluster-8309.30249 BP_3 30.91 0.63 2653 270012313 EFA08761.1 390 1.0e-34 hypothetical protein TcasGA2_TC006440 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q93373 201 3.5e-14 Leucine-rich repeat-containing protein let-4 OS=Caenorhabditis elegans GN=let-4 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.3025 BP_3 44.69 1.26 1996 -- -- -- -- -- 642915699 XM_008192543.1 136 2.24753e-62 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF05210 Sprouty protein (Spry) GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development -- -- GO:0016020 membrane -- -- Cluster-8309.30257 BP_3 1992.89 51.25 2166 817063934 XP_012253687.1 2161 3.7e-240 PREDICTED: histone deacetylase Rpd3 [Athalia rosae] 642917923 XM_961540.2 542 0 PREDICTED: Tribolium castaneum histone deacetylase Rpd3 (LOC655044), mRNA K06067 HDAC1_2 histone deacetylase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06067 Q94517 2126 1.7e-237 Histone deacetylase Rpd3 OS=Drosophila melanogaster GN=Rpd3 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.30258 BP_3 77.27 1.64 2558 817063934 XP_012253687.1 2127 3.8e-236 PREDICTED: histone deacetylase Rpd3 [Athalia rosae] 642917923 XM_961540.2 542 0 PREDICTED: Tribolium castaneum histone deacetylase Rpd3 (LOC655044), mRNA K06067 HDAC1_2 histone deacetylase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06067 Q94517 2124 3.5e-237 Histone deacetylase Rpd3 OS=Drosophila melanogaster GN=Rpd3 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.30259 BP_3 622.69 15.60 2216 861650871 KMQ97471.1 2131 1.1e-236 histone deacetylase rpd3 [Lasius niger] 642917923 XM_961540.2 542 0 PREDICTED: Tribolium castaneum histone deacetylase Rpd3 (LOC655044), mRNA K06067 HDAC1_2 histone deacetylase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06067 Q94517 2124 3.0e-237 Histone deacetylase Rpd3 OS=Drosophila melanogaster GN=Rpd3 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.30262 BP_3 12.51 0.45 1618 642923453 XP_008193751.1 1009 1.1e-106 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QM06 393 1.2e-36 Sterol regulatory element-binding protein cleavage-activating protein OS=Bos taurus GN=SCAP PE=2 SV=1 PF00400//PF07569//PF01437 WD domain, G-beta repeat//TUP1-like enhancer of split//Plexin repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020//GO:0005634 membrane//nucleus KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.30263 BP_3 260.23 2.25 5856 642923453 XP_008193751.1 4355 0.0e+00 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1597 1.0e-175 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF02460//PF00400 Patched family//WD domain, G-beta repeat GO:0007165 signal transduction GO:0008158//GO:0005515 hedgehog receptor activity//protein binding GO:0016020 membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.30265 BP_3 17.35 0.40 2361 91079020 XP_974879.1 654 2.2e-65 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q7ZT42 387 8.4e-36 Staphylococcal nuclease domain-containing protein 1 OS=Danio rerio GN=snd1 PE=2 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.30266 BP_3 1311.00 27.01 2631 91083669 XP_968061.1 2736 9.4e-307 PREDICTED: transmembrane 9 superfamily member 4 [Tribolium castaneum]>gi|642924284|ref|XP_008194231.1| PREDICTED: transmembrane 9 superfamily member 4 [Tribolium castaneum] -- -- -- -- -- K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q5RDY2 1922 9.5e-214 Transmembrane 9 superfamily member 4 OS=Pongo abelii GN=TM9SF4 PE=2 SV=1 PF01445//PF02990 Viral small hydrophobic protein//Endomembrane protein 70 -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.30267 BP_3 171.87 2.50 3610 91088055 XP_967186.1 1525 3.4e-166 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 111 3.23347e-48 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q2NL29 1296 5.1e-141 Inositol-3-phosphate synthase 1 OS=Bos taurus GN=ISYNA1 PE=2 SV=1 PF13912//PF07994//PF13762 C2H2-type zinc finger//Myo-inositol-1-phosphate synthase//Mitochondrial splicing apparatus component GO:0006021//GO:0000372//GO:0019872//GO:0008654 inositol biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//phospholipid biosynthetic process GO:0046872//GO:0004512//GO:0000166 metal ion binding//inositol-3-phosphate synthase activity//nucleotide binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.30268 BP_3 1354.29 23.88 3025 91088055 XP_967186.1 2083 5.7e-231 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 138 2.64742e-63 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q7ZXY0 1709 5.5e-189 Inositol-3-phosphate synthase 1-A OS=Xenopus laevis GN=isyna1-a PE=2 SV=1 PF13762//PF07994//PF13912 Mitochondrial splicing apparatus component//Myo-inositol-1-phosphate synthase//C2H2-type zinc finger GO:0008654//GO:0000372//GO:0019872//GO:0006021 phospholipid biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//inositol biosynthetic process GO:0000166//GO:0004512//GO:0046872 nucleotide binding//inositol-3-phosphate synthase activity//metal ion binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.30271 BP_3 2037.61 5.94 16820 270001730 EEZ98177.1 6767 0.0e+00 hypothetical protein TcasGA2_TC000606 [Tribolium castaneum] 807039419 XM_004534701.2 145 1.90805e-66 PREDICTED: Ceratitis capitata histone-lysine N-methyltransferase trr (LOC101450744), mRNA K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8IRW8 1972 9.7e-219 Histone-lysine N-methyltransferase trr OS=Drosophila melanogaster GN=trr PE=1 SV=2 PF00856//PF05965//PF00628//PF07155//PF05964 SET domain//F/Y rich C-terminus//PHD-finger//ECF-type riboflavin transporter, S component//F/Y-rich N-terminus -- -- GO:0005515 protein binding GO:0016020//GO:0005634 membrane//nucleus KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8309.30272 BP_3 1278.00 24.31 2826 642933328 XP_969796.2 1081 8.2e-115 PREDICTED: glucose-induced degradation protein 4 homolog [Tribolium castaneum] 170048717 XM_001870712.1 115 1.50845e-50 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q8IVV7 887 1.1e-93 Glucose-induced degradation protein 4 homolog OS=Homo sapiens GN=GID4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4635 Vacuolar import and degradation protein Cluster-8309.30273 BP_3 11.00 0.90 883 642927984 XP_008195472.1 421 8.7e-39 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30274 BP_3 4.00 0.50 677 642927984 XP_008195472.1 338 2.8e-29 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30276 BP_3 73.42 1.13 3434 642923787 XP_008193883.1 478 8.3e-45 PREDICTED: uncharacterized protein F13E6.1 [Tribolium castaneum]>gi|642923789|ref|XP_008193884.1| PREDICTED: uncharacterized protein F13E6.1 [Tribolium castaneum]>gi|270006945|gb|EFA03393.1| hypothetical protein TcasGA2_TC013379 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55326 172 1.0e-10 Uncharacterized protein F13E6.1 OS=Caenorhabditis elegans GN=F13E6.1 PE=3 SV=2 PF08603 Adenylate cyclase associated (CAP) C terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG4010 Coiled-coil protein TPD52 Cluster-8309.30279 BP_3 633.00 13.91 2485 91095021 XP_970287.1 743 1.1e-75 PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|642939790|ref|XP_008193677.1| PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|642939793|ref|XP_008193686.1| PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|642939795|ref|XP_008193689.1| PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|270015434|gb|EFA11882.1| hypothetical protein TcasGA2_TC004296 [Tribolium castaneum] -- -- -- -- -- K11980 RNF11 E3 ubiquitin-protein ligase RNF11 http://www.genome.jp/dbget-bin/www_bget?ko:K11980 Q08DI6 520 3.3e-51 RING finger protein 11 OS=Bos taurus GN=RNF11 PE=2 SV=1 PF13639//PF00097//PF01021//PF12861//PF14634//PF12678//PF17123 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//TYA transposon protein//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//RING-H2 zinc finger//RING-like zinc finger GO:0016567 protein ubiquitination GO:0003723//GO:0004842//GO:0005515//GO:0008270//GO:0046872 RNA binding//ubiquitin-protein transferase activity//protein binding//zinc ion binding//metal ion binding GO:0005680//GO:0005737 anaphase-promoting complex//cytoplasm KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.30281 BP_3 199.35 3.53 3011 478263377 ENN81749.1 1019 1.4e-107 hypothetical protein YQE_01842, partial [Dendroctonus ponderosae] 642918138 XM_008193161.1 274 6.58872e-139 PREDICTED: Tribolium castaneum hepatic leukemia factor-like (LOC655431), partial mRNA K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q64709 418 2.7e-39 Hepatic leukemia factor OS=Rattus norvegicus GN=Hlf PE=2 SV=1 PF09726//PF03131//PF00170//PF07716 Transmembrane protein//bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634//GO:0016021 transcription factor complex//nucleus//integral component of membrane KOG3119 Basic region leucine zipper transcription factor Cluster-8309.30283 BP_3 27.19 0.31 4476 478263377 ENN81749.1 477 1.4e-44 hypothetical protein YQE_01842, partial [Dendroctonus ponderosae] 642918138 XM_008193161.1 146 1.40445e-67 PREDICTED: Tribolium castaneum hepatic leukemia factor-like (LOC655431), partial mRNA K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q64709 310 1.4e-26 Hepatic leukemia factor OS=Rattus norvegicus GN=Hlf PE=2 SV=1 PF00170//PF07716//PF09726//PF03131 bZIP transcription factor//Basic region leucine zipper//Transmembrane protein//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus -- -- Cluster-8309.30284 BP_3 164.98 30.43 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30285 BP_3 1.00 0.35 428 642931489 XP_008196607.1 149 1.5e-07 PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931491|ref|XP_967441.2| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931493|ref|XP_008196608.1| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07393 Exocyst complex component Sec10 GO:0048278//GO:0006887 vesicle docking//exocytosis -- -- GO:0005737 cytoplasm -- -- Cluster-8309.30286 BP_3 15.53 1.49 793 642931489 XP_008196607.1 358 1.6e-31 PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931491|ref|XP_967441.2| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931493|ref|XP_008196608.1| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum] 572309161 XM_006620318.1 61 4.28426e-21 PREDICTED: Apis dorsata nitrogen permease regulator 2-like protein-like (LOC102670637), transcript variant X2, mRNA -- -- -- -- Q9WUE4 206 2.7e-15 Nitrogen permease regulator 2-like protein OS=Mus musculus GN=Nprl2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30287 BP_3 329.34 11.49 1673 642931489 XP_008196607.1 1654 1.8e-181 PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931491|ref|XP_967441.2| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931493|ref|XP_008196608.1| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum] 572309161 XM_006620318.1 113 1.14596e-49 PREDICTED: Apis dorsata nitrogen permease regulator 2-like protein-like (LOC102670637), transcript variant X2, mRNA -- -- -- -- Q5E9U9 960 2.1e-102 Nitrogen permease regulator 2-like protein OS=Bos taurus GN=NPRL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3789 Nitrogen permease regulator NLRG/NPR2 Cluster-8309.30288 BP_3 13.38 3.28 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30289 BP_3 11.00 0.49 1370 506968727 AGM32707.1 215 1.0e-14 hypothetical protein, partial [Coptotermes formosanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3029 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30291 BP_3 268.12 2.63 5199 642912011 XP_008199059.1 1218 2.0e-130 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30292 BP_3 889.31 4.38 10071 642912009 XP_008199058.1 2159 2.9e-239 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X1 [Tribolium castaneum]>gi|270014484|gb|EFA10932.1| hypothetical protein TcasGA2_TC001759 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96PE2 1043 3.1e-111 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 PF03185//PF01020//PF00621//PF01007 Calcium-activated potassium channel, beta subunit//Ribosomal L40e family//RhoGEF domain//Inward rectifier potassium channel GO:0043087//GO:0042254//GO:0035023//GO:0006813//GO:0006412 regulation of GTPase activity//ribosome biogenesis//regulation of Rho protein signal transduction//potassium ion transport//translation GO:0003735//GO:0005089//GO:0005242//GO:0015269 structural constituent of ribosome//Rho guanyl-nucleotide exchange factor activity//inward rectifier potassium channel activity//calcium-activated potassium channel activity GO:0005840//GO:0016020//GO:0005622//GO:0008076//GO:0016021 ribosome//membrane//intracellular//voltage-gated potassium channel complex//integral component of membrane KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.30294 BP_3 43.45 0.41 5366 642912011 XP_008199059.1 1160 1.1e-123 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05373//PF02892 L-proline 3-hydroxylase, C-terminal//BED zinc finger GO:0055114 oxidation-reduction process GO:0016706//GO:0003677 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//DNA binding -- -- -- -- Cluster-8309.30297 BP_3 319.54 7.66 2302 373842654 AEY77316.1 404 2.1e-36 extracellular Cu/Zn-superoxide dismutase [Phaedon cochleariae] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P24704 315 1.8e-27 Superoxide dismutase [Cu-Zn] 1 OS=Arabidopsis thaliana GN=CSD1 PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.30298 BP_3 55.78 8.53 607 194889650 XP_001977128.1 676 1.6e-68 GG18414 [Drosophila erecta]>gi|190648777|gb|EDV46055.1| GG18414 [Drosophila erecta] 755966671 XM_011307276.1 101 1.87893e-43 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X10, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 552 1.6e-55 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.30299 BP_3 471.00 13.49 1975 546673345 ERL84971.1 868 2.9e-90 hypothetical protein D910_02394 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q91W39 329 3.7e-29 Nuclear receptor coactivator 5 OS=Mus musculus GN=Ncoa5 PE=1 SV=1 PF00076//PF08675 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0046872//GO:0003676//GO:0004535 RNA binding//metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.303 BP_3 19.37 0.54 2018 766932491 XP_011498465.1 280 4.5e-22 PREDICTED: probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.30300 BP_3 158.00 2.18 3791 642923421 XP_008193737.1 1737 9.4e-191 PREDICTED: uncharacterized protein LOC103313112 [Tribolium castaneum]>gi|270008224|gb|EFA04672.1| hypothetical protein TcasGA2_TC014328 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06308 23S rRNA methylase leader peptide (ErmC) GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.30303 BP_3 230.76 9.06 1520 642931807 XP_008196739.1 1528 6.5e-167 PREDICTED: uncharacterized protein LOC658297 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCX1 145 6.2e-08 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30304 BP_3 5.00 37.66 251 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30305 BP_3 1066.11 10.84 5033 642917385 XP_008199669.1 1771 1.4e-194 PREDICTED: uncharacterized protein LOC658463 [Tribolium castaneum]>gi|270003013|gb|EEZ99460.1| hypothetical protein TcasGA2_TC000026 [Tribolium castaneum] -- -- -- -- -- K18586 COQ4 ubiquinone biosynthesis protein COQ4 http://www.genome.jp/dbget-bin/www_bget?ko:K18586 Q1HPV1 735 8.0e-76 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial OS=Bombyx mori PE=2 SV=1 PF05271//PF05019 Tobravirus 2B protein//Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GO:0006744//GO:0019089 ubiquinone biosynthetic process//transmission of virus -- -- -- -- KOG3244 Protein involved in ubiquinone biosynthesis Cluster-8309.30306 BP_3 22.00 4.09 551 817078679 XP_012261722.1 184 1.6e-11 PREDICTED: longitudinals lacking protein, isoform G isoform X25 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF01428 Zinc finger, C2H2 type//Zinc-finger double domain//AN1-like Zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.30307 BP_3 70.76 1.96 2028 91089699 XP_974834.1 1182 1.1e-126 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum]>gi|270011321|gb|EFA07769.1| hypothetical protein TcasGA2_TC005323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 173 4.7e-11 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF00856//PF13414 SET domain//TPR repeat -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.30308 BP_3 3.00 1.10 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30309 BP_3 499.74 5.54 4643 91081241 XP_975643.1 1992 3.1e-220 PREDICTED: interference hedgehog-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 861 1.8e-90 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF13895//PF00041//PF16656//PF02480 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity GO:0016020 membrane -- -- Cluster-8309.30313 BP_3 451.00 19.10 1430 642911124 XP_008200590.1 706 1.3e-71 PREDICTED: peflin [Tribolium castaneum]>gi|270014674|gb|EFA11122.1| hypothetical protein TcasGA2_TC004722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UBV8 385 8.7e-36 Peflin OS=Homo sapiens GN=PEF1 PE=1 SV=1 PF13202//PF13499//PF13405//PF13833//PF00036 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0037 Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.30315 BP_3 836.00 11.22 3883 91093266 XP_971119.1 4978 0.0e+00 PREDICTED: membrane-associated protein Hem [Tribolium castaneum]>gi|270016828|gb|EFA13274.1| Hem [Tribolium castaneum] 462292279 APGK01053803.1 446 0 Dendroctonus ponderosae Seq01053813, whole genome shotgun sequence K05750 NCKAP1, NAP125 NCK-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05750 P55162 4212 0.0e+00 Membrane-associated protein Hem OS=Drosophila melanogaster GN=Hem PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1917 Membrane-associated hematopoietic protein Cluster-8309.30317 BP_3 223.52 2.84 4083 149588751 NP_001092296.1 2699 2.9e-302 fused lobes [Tribolium castaneum]>gi|642928772|ref|XP_008195555.1| PREDICTED: fused lobes isoform X1 [Tribolium castaneum]>gi|148611482|gb|ABQ95985.1| beta-N-acetylglucosaminidase FDL [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 1351 2.4e-147 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0001575//GO:0006027//GO:0005975//GO:0006040 globoside metabolic process//glycosaminoglycan catabolic process//carbohydrate metabolic process//amino sugar metabolic process GO:0004553//GO:0043169//GO:0004563 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//beta-N-acetylhexosaminidase activity -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.30318 BP_3 1003.30 14.99 3518 91087975 XP_973241.1 1156 2.1e-123 PREDICTED: wiskott-Aldrich syndrome protein family member 3 [Tribolium castaneum]>gi|270012052|gb|EFA08500.1| hypothetical protein TcasGA2_TC006152 [Tribolium castaneum] -- -- -- -- -- K06220 WASF WAS protein family http://www.genome.jp/dbget-bin/www_bget?ko:K06220 Q9UPY6 478 3.5e-46 Wiskott-Aldrich syndrome protein family member 3 OS=Homo sapiens GN=WASF3 PE=1 SV=2 PF03358//PF02205//PF07415 NADPH-dependent FMN reductase//WH2 motif//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency GO:0003779//GO:0016491 actin binding//oxidoreductase activity GO:0033644 host cell membrane KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.30319 BP_3 3601.00 62.20 3082 642916521 XP_008191077.1 3677 0.0e+00 PREDICTED: neutral alpha-glucosidase AB isoform X1 [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q8BHN3 2247 2.3e-251 Neutral alpha-glucosidase AB OS=Mus musculus GN=Ganab PE=1 SV=1 PF04049//PF01055 Anaphase promoting complex subunit 8 / Cdc23//Glycosyl hydrolases family 31 GO:0005975//GO:0030071 carbohydrate metabolic process//regulation of mitotic metaphase/anaphase transition GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005680 anaphase-promoting complex KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.30320 BP_3 199.57 4.96 2230 270014846 EFA11294.1 1725 1.4e-189 hypothetical protein TcasGA2_TC010831 [Tribolium castaneum] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 P41239 1033 9.8e-111 Tyrosine-protein kinase CSK OS=Gallus gallus GN=CSK PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.30322 BP_3 1466.36 40.97 2017 270013857 EFA10305.1 162 2.2e-08 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03529 Otx1 transcription factor GO:0007275 multicellular organismal development GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.30324 BP_3 4.00 0.89 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30325 BP_3 63.02 0.31 10191 91078110 XP_973023.1 3894 0.0e+00 PREDICTED: erythroid differentiation-related factor 1 [Tribolium castaneum]>gi|642914959|ref|XP_008190459.1| PREDICTED: erythroid differentiation-related factor 1 [Tribolium castaneum] 749773613 XM_011143880.1 258 1.76265e-129 PREDICTED: Harpegnathos saltator exportin-7 (LOC105184822), transcript variant X8, mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 2233 3.2e-249 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 PF13414//PF03810 TPR repeat//Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0005515//GO:0008536 protein binding//Ran GTPase binding -- -- KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.30328 BP_3 5.00 1.17 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30329 BP_3 74.24 1.51 2664 270001480 EEZ97927.1 1023 4.1e-108 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M3K2 412 1.2e-38 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF01025 GrpE GO:0006457 protein folding GO:0000774//GO:0042803//GO:0051087 adenyl-nucleotide exchange factor activity//protein homodimerization activity//chaperone binding -- -- -- -- Cluster-8309.30330 BP_3 55.46 1.21 2494 795029505 XP_011862965.1 792 2.4e-81 PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi]>gi|795029508|ref|XP_011862966.1| PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi]>gi|795029511|ref|XP_011862967.1| PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi]>gi|795029514|ref|XP_011862968.1| PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 232 8.3e-18 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30334 BP_3 97.07 2.21 2408 531445261 AGT57839.1 675 8.4e-68 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V6D6 388 6.6e-36 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.30335 BP_3 17.00 15.62 337 531445261 AGT57839.1 323 7.7e-28 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V6D6 273 2.0e-23 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.30336 BP_3 80.16 1.75 2497 531445261 AGT57839.1 756 3.5e-77 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 Q9VE01 534 8.0e-53 Probable cytochrome P450 12a5, mitochondrial OS=Drosophila melanogaster GN=Cyp12a5 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.30337 BP_3 116.47 14.96 667 642928567 XP_008199961.1 583 1.1e-57 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 478 6.7e-47 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30342 BP_3 405.59 11.52 1989 189236494 XP_001816015.1 970 4.3e-102 PREDICTED: uncharacterized protein LOC100142441 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12337 MRVI1, IRAG inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate http://www.genome.jp/dbget-bin/www_bget?ko:K12337 Q5RHB5 170 1.0e-10 Lymphoid-restricted membrane protein OS=Danio rerio GN=lrmp PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30343 BP_3 154.15 2.65 3092 189239791 XP_001811527.1 2655 2.7e-297 PREDICTED: oxysterol-binding protein 1 isoform X2 [Tribolium castaneum] 642930859 XM_001811475.2 237 2.50411e-118 PREDICTED: Tribolium castaneum oxysterol-binding protein 1 (LOC657071), transcript variant X2, mRNA -- -- -- -- P22059 1584 1.7e-174 Oxysterol-binding protein 1 OS=Homo sapiens GN=OSBP PE=1 SV=1 PF02371 Transposase IS116/IS110/IS902 family GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- KOG1737 Oxysterol-binding protein Cluster-8309.30346 BP_3 1429.57 60.16 1437 642916928 XP_008199558.1 1741 1.2e-191 PREDICTED: actin-related protein 2/3 complex subunit 1A isoform X2 [Tribolium castaneum] 332376918 BT128642.1 178 7.21613e-86 Dendroctonus ponderosae clone DPO1115_K05 unknown mRNA K05757 ARPC1A_B actin related protein 2/3 complex, subunit 1A/1B http://www.genome.jp/dbget-bin/www_bget?ko:K05757 Q9R0Q6 1232 5.3e-134 Actin-related protein 2/3 complex subunit 1A OS=Mus musculus GN=Arpc1a PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC Cluster-8309.30347 BP_3 26.43 0.97 1600 642916928 XP_008199558.1 1613 9.5e-177 PREDICTED: actin-related protein 2/3 complex subunit 1A isoform X2 [Tribolium castaneum] 332376918 BT128642.1 46 1.92516e-12 Dendroctonus ponderosae clone DPO1115_K05 unknown mRNA K05757 ARPC1A_B actin related protein 2/3 complex, subunit 1A/1B http://www.genome.jp/dbget-bin/www_bget?ko:K05757 Q9R0Q6 1159 1.7e-125 Actin-related protein 2/3 complex subunit 1A OS=Mus musculus GN=Arpc1a PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC Cluster-8309.30348 BP_3 2844.99 41.47 3598 642931661 XP_008196677.1 2801 0.0e+00 PREDICTED: rap1 GTPase-activating protein 1 isoform X5 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.17558e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 3.2e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF09726//PF07836//PF02145 Transmembrane protein//DmpG-like communication domain//Rap/ran-GAP GO:0019439//GO:0051056 aromatic compound catabolic process//regulation of small GTPase mediated signal transduction GO:0016833//GO:0005096 oxo-acid-lyase activity//GTPase activator activity GO:0016021 integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.30349 BP_3 21.62 0.50 2389 270001544 EEZ97991.1 156 1.3e-07 hypothetical protein TcasGA2_TC000388 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30350 BP_3 574.37 2.65 10756 642914280 XP_008201619.1 1367 2.1e-147 PREDICTED: cyclic AMP-dependent transcription factor ATF-6 beta [Tribolium castaneum] 332375533 BT127946.1 81 4.60724e-31 Dendroctonus ponderosae clone DPO1025_H21 unknown mRNA K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q6GM78 703 8.7e-72 Isoaspartyl peptidase/L-asparaginase OS=Xenopus laevis GN=asrgl1 PE=2 SV=1 PF04977//PF04275//PF16866//PF07776//PF14861//PF01112//PF13465//PF03453//PF06156//PF03604//PF00170//PF00096//PF06005//PF01363//PF13912//PF03131//PF01166//PF07716//PF12356//PF07975 Septum formation initiator//Phosphomevalonate kinase//PHD-finger//Zinc-finger associated domain (zf-AD)//Plant antimicrobial peptide//Asparaginase//Zinc-finger double domain//MoeA N-terminal region (domain I and II)//Protein of unknown function (DUF972)//DNA directed RNA polymerase, 7 kDa subunit//bZIP transcription factor//Zinc finger, C2H2 type//Protein of unknown function (DUF904)//FYVE zinc finger//C2H2-type zinc finger//bZIP Maf transcription factor//TSC-22/dip/bun family//Basic region leucine zipper//Protein of unknown function (DUF3643)//TFIIH C1-like domain GO:0006144//GO:0016567//GO:0006351//GO:0032324//GO:0006695//GO:0000917//GO:0043093//GO:0006206//GO:0032465//GO:0006281//GO:0050832//GO:0007049//GO:0006694//GO:0006915//GO:0006355//GO:0006260 purine nucleobase metabolic process//protein ubiquitination//transcription, DNA-templated//molybdopterin cofactor biosynthetic process//cholesterol biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis//pyrimidine nucleobase metabolic process//regulation of cytokinesis//DNA repair//defense response to fungus//cell cycle//steroid biosynthetic process//apoptotic process//regulation of transcription, DNA-templated//DNA replication GO:0004842//GO:0005515//GO:0003677//GO:0046872//GO:0003899//GO:0016787//GO:0003700//GO:0004631//GO:0043565//GO:0008270 ubiquitin-protein transferase activity//protein binding//DNA binding//metal ion binding//DNA-directed RNA polymerase activity//hydrolase activity//transcription factor activity, sequence-specific DNA binding//phosphomevalonate kinase activity//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634//GO:0005737//GO:0005730 transcription factor complex//nucleus//cytoplasm//nucleolus KOG1592 Asparaginase Cluster-8309.30352 BP_3 95.16 0.69 6903 642931369 XP_008196550.1 7220 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931368 XM_008198328.1 1020 0 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X6, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5900 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF10390//PF07353//PF05171//PF05014//PF00225//PF00498//PF00959 RNA polymerase II elongation factor ELL//Uroplakin II//Haemin-degrading HemS.ChuX domain//Nucleoside 2-deoxyribosyltransferase//Kinesin motor domain//FHA domain//Phage lysozyme GO:0009159//GO:0009253//GO:0007018//GO:0006826//GO:0005975//GO:0061024//GO:0007017//GO:0006368//GO:0016998//GO:0006206 deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process//microtubule-based movement//iron ion transport//carbohydrate metabolic process//membrane organization//microtubule-based process//transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process//pyrimidine nucleobase metabolic process GO:0050144//GO:0005524//GO:0005515//GO:0003777//GO:0003796//GO:0070694//GO:0008017 nucleoside deoxyribosyltransferase activity//ATP binding//protein binding//microtubule motor activity//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//microtubule binding GO:0045298//GO:0005874//GO:0030176//GO:0008023 tubulin complex//microtubule//integral component of endoplasmic reticulum membrane//transcription elongation factor complex KOG0245 Kinesin-like protein Cluster-8309.30354 BP_3 135.28 1.64 4272 755874784 XP_011292472.1 2373 1.9e-264 PREDICTED: E3 ubiquitin-protein ligase Nedd-4 isoform X4 [Musca domestica] -- -- -- -- -- K10591 NEDD4, RSP5 E3 ubiquitin-protein ligase NEDD4 http://www.genome.jp/dbget-bin/www_bget?ko:K10591 Q9VVI3 2157 8.7e-241 E3 ubiquitin-protein ligase Nedd-4 OS=Drosophila melanogaster GN=Nedd4 PE=1 SV=2 PF00632//PF00397//PF00168 HECT-domain (ubiquitin-transferase)//WW domain//C2 domain GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.30355 BP_3 139.00 9.69 983 478261092 ENN80647.1 349 2.2e-30 hypothetical protein YQE_02934, partial [Dendroctonus ponderosae]>gi|546679162|gb|ERL89664.1| hypothetical protein D910_07027 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14978//PF01612 Mitochondrial ribosome protein 63//3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding GO:0005761 mitochondrial ribosome -- -- Cluster-8309.30356 BP_3 45.97 0.63 3832 642925170 XP_008194455.1 1287 1.4e-138 PREDICTED: endoglucanase 5-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26224 615 5.0e-62 Endoglucanase F OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) GN=celF PE=3 SV=1 PF09204//PF00759 Bacterial self-protective colicin-like immunity//Glycosyl hydrolase family 9 GO:0006955//GO:0030153//GO:0005975 immune response//bacteriocin immunity//carbohydrate metabolic process GO:0004553//GO:0015643 hydrolase activity, hydrolyzing O-glycosyl compounds//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.30358 BP_3 5.54 0.43 915 780114121 XP_011676955.1 368 1.3e-32 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 328 2.3e-29 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF08052 Ankyrin repeat//Ankyrin repeat//PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process GO:0005515 protein binding -- -- -- -- Cluster-8309.30359 BP_3 29.00 10.13 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30360 BP_3 377.25 5.74 3458 270007492 EFA03940.1 4135 0.0e+00 hypothetical protein TcasGA2_TC014081 [Tribolium castaneum] -- -- -- -- -- K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1972 2.0e-219 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF04625//PF11547 DEC-1 protein, N-terminal region//E3 ubiquitin ligase EDD GO:0007304 chorion-containing eggshell formation GO:0005213//GO:0043130 structural constituent of chorion//ubiquitin binding GO:0005576//GO:0042600 extracellular region//chorion KOG0943 Predicted ubiquitin-protein ligase/hyperplastic discs protein, HECT superfamily Cluster-8309.30361 BP_3 52.40 4.37 870 270004579 EFA01027.1 154 7.9e-08 hypothetical protein TcasGA2_TC003942 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30362 BP_3 6.00 0.34 1154 189239253 XP_001807041.1 810 8.9e-84 PREDICTED: uncharacterized protein LOC100141764 [Tribolium castaneum]>gi|270010382|gb|EFA06830.1| hypothetical protein TcasGA2_TC009773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30364 BP_3 80.50 0.68 5988 642932082 XP_008196850.1 2434 2.2e-271 PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 1037 9.1e-111 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 PF13912//PF08465//PF00096//PF13465 C2H2-type zinc finger//Thymidine kinase from Herpesvirus C-terminal//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006230 pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0005524//GO:0004797//GO:0046872 ATP binding//thymidine kinase activity//metal ion binding -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.30367 BP_3 419.10 1.90 10903 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.30370 BP_3 7.40 0.42 1151 642931035 XP_008196187.1 199 6.3e-13 PREDICTED: uncharacterized protein LOC103313793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00520//PF06305 Ion transport protein//Protein of unknown function (DUF1049) GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.30375 BP_3 112.69 2.50 2467 478250520 ENN71015.1 808 3.2e-83 hypothetical protein YQE_12415, partial [Dendroctonus ponderosae] 850318596 XM_013007893.1 39 2.32913e-08 PREDICTED: Echinops telfairi L-lactate dehydrogenase A chain-like (LOC101645051), mRNA K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 724 7.3e-75 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF02427//PF00056//PF03721//PF08686//PF02737//PF02866 Photosystem I reaction centre subunit IV / PsaE//lactate/malate dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//PLAC (protease and lacunin) domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0006552//GO:0006631//GO:0015979//GO:0018874//GO:0006633//GO:0006554//GO:0055114//GO:0006568//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//photosynthesis//benzoate metabolic process//fatty acid biosynthetic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//valine catabolic process//isoleucine catabolic process GO:0016491//GO:0051287//GO:0008233//GO:0003857//GO:0016616 oxidoreductase activity//NAD binding//peptidase activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0009538//GO:0009522 photosystem I reaction center//photosystem I KOG1495 Lactate dehydrogenase Cluster-8309.30376 BP_3 286.35 4.83 3150 283046718 NP_001164305.1 2081 1.0e-230 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 432 0 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q91YT0 1897 9.0e-211 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus GN=Ndufv1 PE=1 SV=1 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region GO:0006120//GO:0006744//GO:0006814//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//proton transport//oxidation-reduction process GO:0010181//GO:0051287//GO:0008137//GO:0051539 FMN binding//NAD binding//NADH dehydrogenase (ubiquinone) activity//4 iron, 4 sulfur cluster binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.30378 BP_3 56.57 3.45 1081 91094163 XP_970089.1 440 6.7e-41 PREDICTED: neuralized-like protein 2 [Tribolium castaneum]>gi|270010902|gb|EFA07350.1| hypothetical protein TcasGA2_TC015949 [Tribolium castaneum] -- -- -- -- -- K16782 NEURL2 neuralized-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16782 Q9D0S4 188 4.6e-13 Neuralized-like protein 2 OS=Mus musculus GN=Neurl2 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- GO:0005622 intracellular -- -- Cluster-8309.30379 BP_3 120.67 4.15 1692 332374134 AEE62208.1 733 1.1e-74 unknown [Dendroctonus ponderosae]>gi|478257958|gb|ENN78096.1| hypothetical protein YQE_05250, partial [Dendroctonus ponderosae]>gi|546676502|gb|ERL87500.1| hypothetical protein D910_04892 [Dendroctonus ponderosae] -- -- -- -- -- K16782 NEURL2 neuralized-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16782 Q9D0S4 382 2.3e-35 Neuralized-like protein 2 OS=Mus musculus GN=Neurl2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.30386 BP_3 8.00 0.82 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30390 BP_3 255.00 7.07 2029 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane -- -- Cluster-8309.30391 BP_3 375.10 25.14 1011 642911665 XP_969599.2 616 2.4e-61 PREDICTED: uncharacterized protein C45G9.7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09506 313 1.4e-27 Uncharacterized protein C45G9.7 OS=Caenorhabditis elegans GN=C45G9.7 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3553 Tax interaction protein TIP1 Cluster-8309.30392 BP_3 13.60 0.53 1539 642911665 XP_969599.2 311 8.6e-26 PREDICTED: uncharacterized protein C45G9.7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09506 182 3.2e-12 Uncharacterized protein C45G9.7 OS=Caenorhabditis elegans GN=C45G9.7 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3553 Tax interaction protein TIP1 Cluster-8309.30393 BP_3 351.00 15.29 1398 478252105 ENN72536.1 459 5.4e-43 hypothetical protein YQE_10876, partial [Dendroctonus ponderosae]>gi|546683902|gb|ERL93650.1| hypothetical protein D910_10938 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30394 BP_3 121.61 2.24 2906 557332086 XP_006038864.1 379 2.1e-33 PREDICTED: zinc finger protein 850-like [Alligator sinensis] -- -- -- -- -- K09229 ZKSCAN KRAB and SCAN domains-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09229 Q9EQB9 365 3.7e-33 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF02701//PF13465//PF07975//PF13912//PF02892//PF16622//PF00096//PF02772//PF01155 Dof domain, zinc finger//Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//S-adenosylmethionine synthetase, central domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006555//GO:0006556//GO:0006355//GO:0006281//GO:0006464 methionine metabolic process//S-adenosylmethionine biosynthetic process//regulation of transcription, DNA-templated//DNA repair//cellular protein modification process GO:0046872//GO:0008270//GO:0016151//GO:0004478//GO:0003677 metal ion binding//zinc ion binding//nickel cation binding//methionine adenosyltransferase activity//DNA binding -- -- -- -- Cluster-8309.30395 BP_3 645912.95 27447.32 1426 642922021 XP_008192988.1 358 2.8e-31 PREDICTED: adult-specific cuticular protein ACP-20-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 360 6.9e-33 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30396 BP_3 255.85 2.39 5446 642927078 XP_008195127.1 1453 1.2e-157 PREDICTED: probable G-protein coupled receptor Mth-like 5 [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VGG8 1038 6.3e-111 Probable G-protein coupled receptor Mth-like 5 OS=Drosophila melanogaster GN=mthl5 PE=2 SV=2 PF00001//PF02742//PF00002 7 transmembrane receptor (rhodopsin family)//Iron dependent repressor, metal binding and dimerisation domain//7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0046914//GO:0046983 G-protein coupled receptor activity//transition metal ion binding//protein dimerization activity GO:0016021 integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.30398 BP_3 721.96 39.85 1165 91094297 XP_971720.1 1187 1.7e-127 PREDICTED: estradiol 17-beta-dehydrogenase 12 [Tribolium castaneum]>gi|270014405|gb|EFA10853.1| hypothetical protein TcasGA2_TC001630 [Tribolium castaneum] -- -- -- -- -- K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10251 Q28IU1 690 3.0e-71 Very-long-chain 3-oxoacyl-CoA reductase OS=Xenopus tropicalis GN=hsd17b12 PE=2 SV=1 PF02882//PF00106//PF02737//PF03435//PF01370 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family GO:0046487//GO:0009396//GO:0006574//GO:0006550//GO:0055114//GO:0006554//GO:0006568//GO:0008152//GO:0006633//GO:0018874//GO:0006552//GO:0006631 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//valine catabolic process//isoleucine catabolic process//oxidation-reduction process//lysine catabolic process//tryptophan metabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//leucine catabolic process//fatty acid metabolic process GO:0004488//GO:0050662//GO:0003857//GO:0000166//GO:0016491//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//coenzyme binding//3-hydroxyacyl-CoA dehydrogenase activity//nucleotide binding//oxidoreductase activity//catalytic activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.30399 BP_3 258.02 11.69 1356 91089719 XP_974982.1 1687 2.1e-185 PREDICTED: methyltransferase-like protein 14 homolog [Tribolium castaneum]>gi|270012642|gb|EFA09090.1| hypothetical protein TcasGA2_TC006811 [Tribolium castaneum] 768446739 XM_011567022.1 116 1.98641e-51 PREDICTED: Plutella xylostella methyltransferase-like protein 14 homolog (LOC105395098), mRNA K05925 METTL3_14 mRNA (2'-O-methyladenosine-N6-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05925 Q9VLP7 1399 2.2e-153 Methyltransferase-like protein 14 homolog OS=Drosophila melanogaster GN=CG7818 PE=2 SV=1 PF05063 MT-A70 GO:0032259//GO:0006139 methylation//nucleobase-containing compound metabolic process GO:0008168 methyltransferase activity -- -- KOG2097 Predicted N6-adenine methylase involved in transcription regulation Cluster-8309.304 BP_3 7.00 0.63 825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30400 BP_3 6.00 3.77 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30402 BP_3 1152.00 24.23 2583 478251189 ENN71665.1 2418 6.9e-270 hypothetical protein YQE_11763, partial [Dendroctonus ponderosae] -- -- -- -- -- K03419 CHPF2 chondroitin polymerizing factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03419 Q6IQX7 665 5.3e-68 Chondroitin sulfate synthase 2 OS=Mus musculus GN=Chpf PE=1 SV=1 PF05679//PF03526 Chondroitin N-acetylgalactosaminyltransferase//Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0008376//GO:0015643 acetylgalactosaminyltransferase activity//toxic substance binding GO:0019814//GO:0032580 immunoglobulin complex//Golgi cisterna membrane KOG3708 Uncharacterized conserved protein Cluster-8309.30403 BP_3 295.00 12.50 1429 91080237 XP_972872.1 450 6.1e-42 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30404 BP_3 114.11 1.20 4874 478252635 ENN73040.1 2511 2.2e-280 hypothetical protein YQE_10375, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q07139 1014 3.4e-108 Protein ECT2 OS=Mus musculus GN=Ect2 PE=1 SV=2 PF00621//PF02419 RhoGEF domain//PsbL protein GO:0035023//GO:0043087//GO:0015979 regulation of Rho protein signal transduction//regulation of GTPase activity//photosynthesis GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE) Cluster-8309.30409 BP_3 1600.00 99.99 1063 91095009 XP_969881.1 670 1.4e-67 PREDICTED: translocon-associated protein subunit gamma [Tribolium castaneum]>gi|270015431|gb|EFA11879.1| hypothetical protein TcasGA2_TC004293 [Tribolium castaneum] 769843857 XM_011634857.1 98 1.56987e-41 PREDICTED: Pogonomyrmex barbatus translocon-associated protein subunit gamma (LOC105424561), mRNA K13251 SSR3 translocon-associated protein subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K13251 Q9UNL2 502 1.8e-49 Translocon-associated protein subunit gamma OS=Homo sapiens GN=SSR3 PE=1 SV=1 PF05298//PF15048//PF07074 Bombinin//Organic solute transporter subunit beta protein//Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0006810//GO:0015721//GO:0006613//GO:0042742 transport//bile acid and bile salt transport//cotranslational protein targeting to membrane//defense response to bacterium GO:0005215//GO:0046982 transporter activity//protein heterodimerization activity GO:0005784//GO:0030176//GO:0005886//GO:0005576 Sec61 translocon complex//integral component of endoplasmic reticulum membrane//plasma membrane//extracellular region KOG4490 Translocon-associated complex TRAP, gamma subunit Cluster-8309.30410 BP_3 2327.85 15.66 7457 642939202 XP_008200380.1 3478 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 167 4.97226e-79 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1288 8.9e-140 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF03547//PF00002//PF02617//PF02140//PF01825//PF02793 Membrane transport protein//7 transmembrane receptor (Secretin family)//ATP-dependent Clp protease adaptor protein ClpS//Galactose binding lectin domain//GPCR proteolysis site, GPS, motif//Hormone receptor domain GO:0030163//GO:0007186//GO:0055085 protein catabolic process//G-protein coupled receptor signaling pathway//transmembrane transport GO:0030246//GO:0004930 carbohydrate binding//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG4193 G protein-coupled receptors Cluster-8309.30411 BP_3 362.81 7.28 2694 270007885 EFA04333.1 652 4.4e-65 hypothetical protein TcasGA2_TC014627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7K0 382 3.6e-35 Inactive hydroxysteroid dehydrogenase-like protein 1 OS=Pongo abelii GN=HSDL1 PE=2 SV=1 PF00709//PF00106//PF02737//PF01356//PF12242 Adenylosuccinate synthetase//short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Alpha amylase inhibitor//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0006531//GO:0006144//GO:0018874//GO:0006633//GO:0008152//GO:0006552//GO:0006522//GO:0006631//GO:0006164//GO:0006550//GO:0006574//GO:0055114//GO:0006554//GO:0006568 aspartate metabolic process//purine nucleobase metabolic process//benzoate metabolic process//fatty acid biosynthetic process//metabolic process//leucine catabolic process//alanine metabolic process//fatty acid metabolic process//purine nucleotide biosynthetic process//isoleucine catabolic process//valine catabolic process//oxidation-reduction process//lysine catabolic process//tryptophan metabolic process GO:0016491//GO:0005525//GO:0004019//GO:0003857//GO:0015066 oxidoreductase activity//GTP binding//adenylosuccinate synthase activity//3-hydroxyacyl-CoA dehydrogenase activity//alpha-amylase inhibitor activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.30412 BP_3 1013.85 42.04 1454 478259232 ENN79134.1 2074 3.0e-230 hypothetical protein YQE_04320, partial [Dendroctonus ponderosae] 462360259 APGK01029452.1 244 1.49397e-122 Dendroctonus ponderosae Seq01029462, whole genome shotgun sequence K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 Q95ZS2 1542 6.1e-170 Tyrosine decarboxylase OS=Caenorhabditis elegans GN=tdc-1 PE=2 SV=1 PF04655//PF00282 Aminoglycoside/hydroxyurea antibiotic resistance kinase//Pyridoxal-dependent decarboxylase conserved domain GO:0019748//GO:0006468//GO:0019752 secondary metabolic process//protein phosphorylation//carboxylic acid metabolic process GO:0016773//GO:0016831//GO:0030170 phosphotransferase activity, alcohol group as acceptor//carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.30413 BP_3 183.00 1.71 5435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30414 BP_3 62.55 0.70 4578 642926929 XP_008195061.1 1125 1.1e-119 PREDICTED: uncharacterized protein LOC100141786 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30416 BP_3 28.13 0.55 2769 270006157 EFA02605.1 2133 8.3e-237 hypothetical protein TcasGA2_TC008324 [Tribolium castaneum] 332375782 BT128071.1 218 8.16925e-108 Dendroctonus ponderosae clone DPO116_B20 unknown mRNA K01892 HARS, hisS histidyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01892 Q61035 1637 1.1e-180 Histidine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Hars PE=2 SV=2 PF00587//PF00152//PF00458 tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N)//WHEP-TRS domain GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//ATP binding//nucleotide binding -- -- KOG1936 Histidyl-tRNA synthetase Cluster-8309.30417 BP_3 5983.78 84.05 3723 546673598 ERL85162.1 1169 6.8e-125 hypothetical protein D910_02584, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R5M3 279 4.4e-23 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30418 BP_3 1993.62 41.88 2586 91087843 XP_968073.1 1529 8.5e-167 PREDICTED: ceramide synthase 6-like [Tribolium castaneum] 347966517 XM_321321.5 153 1.03679e-71 Anopheles gambiae str. PEST AGAP001761-PA (AgaP_AGAP001761) mRNA, complete cds K04710 CERS ceramide synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K04710 Q8C172 760 5.2e-79 Ceramide synthase 6 OS=Mus musculus GN=Cers6 PE=1 SV=1 PF03798//PF12766//PF00046 TLC domain//Pyridoxamine 5'-phosphate oxidase//Homeobox domain -- -- GO:0003677//GO:0010181 DNA binding//FMN binding GO:0016021 integral component of membrane KOG1607 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.30419 BP_3 473.00 8.33 3030 189233641 XP_001814986.1 2204 5.3e-245 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 817217362 XM_012429207.1 113 2.09398e-49 PREDICTED: Orussus abietinus nicotinate phosphoribosyltransferase (LOC105702012), transcript variant X3, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2042 1.3e-227 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain -- -- GO:0016763 transferase activity, transferring pentosyl groups -- -- KOG2511 Nicotinic acid phosphoribosyltransferase Cluster-8309.30420 BP_3 52.25 0.82 3379 642927450 XP_008195278.1 715 2.7e-72 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X2 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 360 1.6e-32 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF07650//PF00013//PF13184//PF13014 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.30422 BP_3 2458.80 35.07 3671 642911714 XP_008200711.1 876 6.3e-91 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 704 2.3e-72 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.30423 BP_3 2569.00 33.03 4041 91083057 XP_966898.1 5003 0.0e+00 PREDICTED: cohesin subunit SA-1 [Tribolium castaneum] 815802185 XM_012366342.1 297 1.45307e-151 PREDICTED: Linepithema humile cohesin subunit SA-2 (LOC105671847), mRNA K06671 STAG1_2, SCC3, IRR1 cohesin complex subunit SA-1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06671 Q8WVM7 2531 3.5e-284 Cohesin subunit SA-1 OS=Homo sapiens GN=STAG1 PE=1 SV=3 PF09236//PF00858 Alpha-haemoglobin stabilising protein//Amiloride-sensitive sodium channel GO:0006814//GO:0020027//GO:0030097//GO:0006457//GO:0050821 sodium ion transport//hemoglobin metabolic process//hemopoiesis//protein folding//protein stabilization GO:0005272//GO:0030492 sodium channel activity//hemoglobin binding GO:0016020//GO:0005833 membrane//hemoglobin complex KOG2011 Sister chromatid cohesion complex Cohesin, subunit STAG/IRR1/SCC3 Cluster-8309.30424 BP_3 28.02 1.35 1290 91078580 XP_971846.1 727 4.2e-74 PREDICTED: UDP-N-acetylglucosamine transferase subunit ALG14 homolog [Tribolium castaneum]>gi|270004042|gb|EFA00490.1| hypothetical protein TcasGA2_TC003350 [Tribolium castaneum] -- -- -- -- -- K07441 ALG14 beta-1,4-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07441 Q9D081 457 3.5e-44 UDP-N-acetylglucosamine transferase subunit ALG14 homolog OS=Mus musculus GN=Alg14 PE=2 SV=1 PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0005634//GO:0000775 nucleus//chromosome, centromeric region KOG3339 Predicted glycosyltransferase Cluster-8309.30425 BP_3 50.33 0.38 6673 91086487 XP_970606.1 1037 2.5e-109 PREDICTED: putative Rab-43-like protein ENSP00000330714 [Tribolium castaneum]>gi|270009806|gb|EFA06254.1| hypothetical protein TcasGA2_TC009113 [Tribolium castaneum] -- -- -- -- -- K07930 RAB43 Ras-related protein Rab-43 http://www.genome.jp/dbget-bin/www_bget?ko:K07930 Q86YS6 619 3.0e-62 Ras-related protein Rab-43 OS=Homo sapiens GN=RAB43 PE=1 SV=1 PF04670//PF10662//PF00071//PF02367//PF00025//PF14991//PF00096//PF08710//PF01926//PF08513//PF08477 Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ADP-ribosylation factor family//Protein melan-A//Zinc finger, C2H2 type//nsp9 replicase//50S ribosome-binding GTPase//LisH//Ras of Complex, Roc, domain of DAPkinase GO:0019079//GO:0006576//GO:0002949//GO:0007264//GO:0015031 viral genome replication//cellular biogenic amine metabolic process//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction//protein transport GO:0003723//GO:0005524//GO:0005515//GO:0005525//GO:0046872 RNA binding//ATP binding//protein binding//GTP binding//metal ion binding GO:0042470 melanosome KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.30427 BP_3 326.00 7.40 2415 189238877 XP_973702.2 2065 5.6e-229 PREDICTED: transcription factor IIIB 90 kDa subunit [Tribolium castaneum] 645033290 XM_008216720.1 92 7.85724e-38 PREDICTED: Nasonia vitripennis transcription factor IIIB 90 kDa subunit (LOC100123706), transcript variant X4, mRNA K15196 BRF1, GTF3B transcription factor IIIB 90 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15196 Q8CFK2 1199 6.0e-130 Transcription factor IIIB 90 kDa subunit OS=Mus musculus GN=Brf1 PE=2 SV=1 PF00382 Transcription factor TFIIB repeat -- -- GO:0017025 TBP-class protein binding -- -- KOG1598 Transcription initiation factor TFIIIB, Brf1 subunit Cluster-8309.30428 BP_3 2.31 0.56 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30429 BP_3 20.71 0.57 2028 91088191 XP_972764.1 335 1.9e-28 PREDICTED: ribonuclease UK114 [Tribolium castaneum]>gi|270012137|gb|EFA08585.1| hypothetical protein TcasGA2_TC006240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52759 285 4.9e-24 Ribonuclease UK114 OS=Rattus norvegicus GN=Hrsp12 PE=1 SV=3 PF08675 RNA binding domain GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0046872//GO:0003723//GO:0004535 metal ion binding//RNA binding//poly(A)-specific ribonuclease activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG2317 Putative translation initiation inhibitor UK114/IBM1 Cluster-8309.30430 BP_3 95.94 1.17 4238 642913457 XP_008201020.1 3244 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.3e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00784//PF00023 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.30431 BP_3 39.30 0.48 4222 91093345 XP_967700.1 926 1.2e-96 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X9 [Tribolium castaneum] 642938317 XM_962607.3 231 7.42474e-115 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 P81269 205 1.9e-14 Cyclic AMP-dependent transcription factor ATF-1 OS=Mus musculus GN=Atf1 PE=1 SV=1 PF03131//PF00170//PF07716//PF02173 bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper//pKID domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700//GO:0005515 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.30432 BP_3 2.00 1.65 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30433 BP_3 3790.42 20.08 9392 642937160 XP_969386.2 1135 1.5e-120 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] 242018355 XM_002429598.1 78 1.87077e-29 Pediculus humanus corporis Prolyl 4-hydroxylase alpha-1 subunit precursor, putative, mRNA K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 Q5RAG8 833 6.4e-87 Prolyl 4-hydroxylase subunit alpha-1 OS=Pongo abelii GN=P4HA1 PE=2 SV=1 PF08476//PF08336//PF13640//PF03171//PF00312 Viral D10 N-terminal//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//2OG-Fe(II) oxygenase superfamily//2OG-Fe(II) oxygenase superfamily//Ribosomal protein S15 GO:0006412//GO:0006560//GO:0006525//GO:0018401//GO:0055114//GO:0042254 translation//proline metabolic process//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//oxidation-reduction process//ribosome biogenesis GO:0016702//GO:0016791//GO:0016491//GO:0004656//GO:0003735 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//phosphatase activity//oxidoreductase activity//procollagen-proline 4-dioxygenase activity//structural constituent of ribosome GO:0005783//GO:0005840//GO:0005622 endoplasmic reticulum//ribosome//intracellular KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.30434 BP_3 95.14 0.47 10023 642937160 XP_969386.2 1135 1.6e-120 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] 242018355 XM_002429598.1 78 1.99696e-29 Pediculus humanus corporis Prolyl 4-hydroxylase alpha-1 subunit precursor, putative, mRNA K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 P13674 833 6.9e-87 Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens GN=P4HA1 PE=1 SV=2 PF03171//PF08336//PF08476//PF13640 2OG-Fe(II) oxygenase superfamily//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Viral D10 N-terminal//2OG-Fe(II) oxygenase superfamily GO:0006560//GO:0006525//GO:0018401//GO:0055114 proline metabolic process//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//oxidation-reduction process GO:0016702//GO:0016791//GO:0016491//GO:0004656 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//phosphatase activity//oxidoreductase activity//procollagen-proline 4-dioxygenase activity GO:0005783 endoplasmic reticulum KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.30437 BP_3 841.60 5.06 8306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05399//PF04805 Ectropic viral integration site 2A protein (EVI2A)//E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30438 BP_3 90.40 0.54 8291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05399//PF04805 Ectropic viral integration site 2A protein (EVI2A)//E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30439 BP_3 84.00 2.46 1935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30440 BP_3 2.00 0.39 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30441 BP_3 233.98 7.36 1825 801404410 XP_012061865.1 1863 1.1e-205 PREDICTED: 26S protease regulatory subunit 6B [Atta cephalotes] 194762611 XM_001963392.1 392 0 Drosophila ananassae GF20295 (Dana\GF20295), mRNA K03063 PSMC4, RPT3 26S proteasome regulatory subunit T3 http://www.genome.jp/dbget-bin/www_bget?ko:K03063 P46507 1847 3.3e-205 26S protease regulatory subunit 6B OS=Manduca sexta PE=2 SV=1 PF05496//PF06068//PF07724//PF00005//PF03266//PF07726//PF01637//PF00910//PF01695//PF07728//PF01057//PF00158//PF00004//PF02367//PF06414//PF00931 Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//AAA domain (Cdc48 subfamily)//ABC transporter//NTPase//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//RNA helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//NB-ARC domain GO:0019079//GO:0006281//GO:0006355//GO:0006310//GO:0002949 viral genome replication//DNA repair//regulation of transcription, DNA-templated//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0098519//GO:0008134//GO:0016887//GO:0016301//GO:0003723//GO:0003678//GO:0043531//GO:0003724//GO:0009378 ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//ATPase activity//kinase activity//RNA binding//DNA helicase activity//ADP binding//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0727 26S proteasome regulatory complex, ATPase RPT3 Cluster-8309.30445 BP_3 2.00 0.78 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30446 BP_3 103.15 1.37 3926 642928921 XP_008195617.1 3655 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 939 1.4e-99 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.30447 BP_3 231.43 4.15 2978 270009865 EFA06313.1 2023 5.1e-224 hypothetical protein TcasGA2_TC009182 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REG1 838 5.4e-88 Squamous cell carcinoma antigen recognized by T-cells 3 OS=Pongo abelii GN=SART3 PE=2 SV=1 PF13174//PF16367//PF13414//PF00076//PF05843//PF08777 Tetratricopeptide repeat//RNA recognition motif//TPR repeat//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Suppressor of forked protein (Suf)//RNA binding motif GO:0006397 mRNA processing GO:0005515//GO:0003723//GO:0003676 protein binding//RNA binding//nucleic acid binding GO:0005634 nucleus KOG0128 RNA-binding protein SART3 (RRM superfamily) Cluster-8309.30449 BP_3 113.34 3.09 2061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30451 BP_3 301.33 2.58 5914 91088827 XP_970265.1 2242 4.1e-249 PREDICTED: THO complex subunit 1 [Tribolium castaneum]>gi|270012332|gb|EFA08780.1| hypothetical protein TcasGA2_TC006470 [Tribolium castaneum] 805773091 XM_003701730.2 90 2.50946e-36 PREDICTED: Megachile rotundata THO complex subunit 1 (LOC100880227), mRNA K12878 THOC1 THO complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12878 Q96FV9 1053 1.2e-112 THO complex subunit 1 OS=Homo sapiens GN=THOC1 PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2491 Nuclear matrix protein Cluster-8309.30452 BP_3 68.96 0.59 5932 91088827 XP_970265.1 2242 4.1e-249 PREDICTED: THO complex subunit 1 [Tribolium castaneum]>gi|270012332|gb|EFA08780.1| hypothetical protein TcasGA2_TC006470 [Tribolium castaneum] 805773091 XM_003701730.2 90 2.51714e-36 PREDICTED: Megachile rotundata THO complex subunit 1 (LOC100880227), mRNA K12878 THOC1 THO complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12878 Q96FV9 1053 1.3e-112 THO complex subunit 1 OS=Homo sapiens GN=THOC1 PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2491 Nuclear matrix protein Cluster-8309.30453 BP_3 3.00 0.49 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30455 BP_3 428.06 8.91 2607 91083569 XP_967824.1 831 7.4e-86 PREDICTED: transport and Golgi organization protein 11 [Tribolium castaneum]>gi|270007821|gb|EFA04269.1| hypothetical protein TcasGA2_TC014559 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q961C9 347 4.0e-31 Transport and Golgi organization protein 11 OS=Drosophila melanogaster GN=Tango11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30456 BP_3 84.45 1.29 3448 546678918 ERL89456.1 350 5.8e-30 hypothetical protein D910_06823 [Dendroctonus ponderosae] 462304277 APGK01049550.1 107 5.16549e-46 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q867Z4 288 3.7e-24 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00444//PF16622//PF01428//PF04926//PF02892//PF01155//PF00096 Zinc-finger double domain//Ribosomal protein L36//zinc-finger C2H2-type//AN1-like Zinc finger//Poly(A) polymerase predicted RNA binding domain//BED zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type GO:0042254//GO:0006412//GO:0006464//GO:0043631 ribosome biogenesis//translation//cellular protein modification process//RNA polyadenylation GO:0046872//GO:0003735//GO:0008270//GO:0016151//GO:0003723//GO:0003677 metal ion binding//structural constituent of ribosome//zinc ion binding//nickel cation binding//RNA binding//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.30457 BP_3 342.07 3.37 5181 270004788 EFA01236.1 630 3.0e-62 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30458 BP_3 393.86 5.81 3561 642935103 XP_008197888.1 1698 3.0e-186 PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935105|ref|XP_008197889.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935107|ref|XP_008197890.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935109|ref|XP_008197891.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935111|ref|XP_008197892.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.30459 BP_3 225.57 8.25 1610 478250982 ENN71466.1 427 3.2e-39 hypothetical protein YQE_11883, partial [Dendroctonus ponderosae]>gi|546682648|gb|ERL92560.1| hypothetical protein D910_09873 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30461 BP_3 427.83 4.87 4523 91079298 XP_966796.1 1790 8.1e-197 PREDICTED: putative sodium-coupled neutral amino acid transporter 10 [Tribolium castaneum]>gi|270004319|gb|EFA00767.1| hypothetical protein TcasGA2_TC003653 [Tribolium castaneum] -- -- -- -- -- K14996 SLC38A10 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14996 Q6PCF9 774 2.1e-80 Putative sodium-coupled neutral amino acid transporter 10 OS=Xenopus laevis GN=slc38a10 PE=2 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1305 Amino acid transporter protein Cluster-8309.30462 BP_3 367.92 3.23 5776 642923025 XP_008200500.1 3006 0.0e+00 PREDICTED: protein eyes shut [Tribolium castaneum]>gi|270006587|gb|EFA03035.1| hypothetical protein TcasGA2_TC010461 [Tribolium castaneum] -- -- -- -- -- K14996 SLC38A10 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14996 A0A1F4 1380 1.5e-150 Protein eyes shut OS=Drosophila melanogaster GN=eys PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.30463 BP_3 375.24 3.41 5601 642923025 XP_008200500.1 1797 1.5e-197 PREDICTED: protein eyes shut [Tribolium castaneum]>gi|270006587|gb|EFA03035.1| hypothetical protein TcasGA2_TC010461 [Tribolium castaneum] -- -- -- -- -- K14996 SLC38A10 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14996 Q6PCF9 774 2.7e-80 Putative sodium-coupled neutral amino acid transporter 10 OS=Xenopus laevis GN=slc38a10 PE=2 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.30464 BP_3 38.03 0.39 5048 642938298 XP_008192776.1 2206 5.2e-245 PREDICTED: late secretory pathway protein AVL9 homolog [Tribolium castaneum] 820839237 XM_012495150.1 158 3.38353e-74 PREDICTED: Apis florea late secretory pathway protein AVL9 homolog (LOC100871294), mRNA -- -- -- -- Q80U56 1140 8.7e-123 Late secretory pathway protein AVL9 homolog OS=Mus musculus GN=Avl9 PE=2 SV=2 PF01767 Birnavirus VP3 protein -- -- GO:0005198 structural molecule activity -- -- KOG3823 Uncharacterized conserved protein Cluster-8309.30465 BP_3 10.67 0.51 1295 642925464 XP_008194565.1 397 7.8e-36 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.30467 BP_3 4.39 0.38 842 642937495 XP_008198863.1 148 3.8e-07 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30468 BP_3 180.79 1.62 5666 642913872 XP_008201198.1 1400 1.7e-151 PREDICTED: SH3 domain-containing kinase-binding protein 1 isoform X2 [Tribolium castaneum] 23589286 AK116679.1 38 1.93865e-07 Ciona intestinalis cDNA, clone:cieg003e24, full insert sequence K12470 SH3KBP1, CIN85 SH3 domain-containing kinase-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12470 Q925Q9 306 5.0e-26 SH3 domain-containing kinase-binding protein 1 OS=Rattus norvegicus GN=Sh3kbp1 PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4348 Adaptor protein CMS/SETA Cluster-8309.30469 BP_3 74.80 0.67 5650 642913872 XP_008201198.1 1400 1.7e-151 PREDICTED: SH3 domain-containing kinase-binding protein 1 isoform X2 [Tribolium castaneum] 23589286 AK116679.1 38 1.93314e-07 Ciona intestinalis cDNA, clone:cieg003e24, full insert sequence K12470 SH3KBP1, CIN85 SH3 domain-containing kinase-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12470 Q925Q9 306 5.0e-26 SH3 domain-containing kinase-binding protein 1 OS=Rattus norvegicus GN=Sh3kbp1 PE=1 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4348 Adaptor protein CMS/SETA Cluster-8309.30472 BP_3 151.00 42.17 464 91080431 XP_968599.1 326 4.7e-28 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30473 BP_3 593.28 18.88 1806 91094379 XP_970941.1 1077 1.5e-114 PREDICTED: 39S ribosomal protein L4, mitochondrial [Tribolium castaneum]>gi|270014913|gb|EFA11361.1| hypothetical protein TcasGA2_TC011518 [Tribolium castaneum] -- -- -- -- -- K02926 RP-L4, MRPL4, rplD large subunit ribosomal protein L4 http://www.genome.jp/dbget-bin/www_bget?ko:K02926 Q32PI6 676 2.0e-69 39S ribosomal protein L4, mitochondrial OS=Bos taurus GN=MRPL4 PE=1 SV=1 PF00573//PF03497//PF01084 Ribosomal protein L4/L1 family//Anthrax toxin LF subunit//Ribosomal protein S18 GO:0042254//GO:0006171//GO:0006412//GO:0009405 ribosome biogenesis//cAMP biosynthetic process//translation//pathogenesis GO:0003735//GO:0008294 structural constituent of ribosome//calcium- and calmodulin-responsive adenylate cyclase activity GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1624 Mitochondrial/chloroplast ribosomal protein L4 Cluster-8309.30474 BP_3 15.12 0.57 1579 546684056 ERL93779.1 1363 9.2e-148 hypothetical protein D910_11065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P97535 308 8.1e-27 Phospholipase A1 member A OS=Rattus norvegicus GN=Pla1a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30478 BP_3 62.21 0.79 4089 91094941 XP_967472.1 2771 1.3e-310 PREDICTED: coatomer subunit alpha [Tribolium castaneum]>gi|270016760|gb|EFA13206.1| hypothetical protein TcasGA2_TC016033 [Tribolium castaneum] 817054142 XM_012410510.1 255 3.2744e-128 PREDICTED: Athalia rosae coatomer subunit alpha (LOC105691786), mRNA K05236 COPA coatomer protein complex, subunit alpha (xenin) http://www.genome.jp/dbget-bin/www_bget?ko:K05236 Q8CIE6 2469 5.5e-277 Coatomer subunit alpha OS=Mus musculus GN=Copa PE=1 SV=2 PF06957//PF00400//PF04053//PF13414 Coatomer (COPI) alpha subunit C-terminus//WD domain, G-beta repeat//Coatomer WD associated region//TPR repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG0292 Vesicle coat complex COPI, alpha subunit Cluster-8309.30479 BP_3 291.60 6.71 2386 270015207 EFA11655.1 939 2.0e-98 hypothetical protein TcasGA2_TC004080 [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 A6QNP3 340 2.4e-30 Protein phosphatase 1 regulatory subunit 3B OS=Bos taurus GN=PPP1R3B PE=2 SV=1 PF16760//PF03370 Starch/carbohydrate-binding module (family 53)//Carbohydrate/starch-binding module (family 21) -- -- GO:0005515//GO:2001070 protein binding//starch binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.30480 BP_3 15.58 0.38 2275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30482 BP_3 31.45 0.77 2249 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30484 BP_3 165.71 6.96 1440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.30485 BP_3 1750.25 46.96 2088 478255296 ENN75522.1 1701 7.8e-187 hypothetical protein YQE_07866, partial [Dendroctonus ponderosae]>gi|546683150|gb|ERL93001.1| hypothetical protein D910_10303 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 583 1.4e-58 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.30489 BP_3 182.18 7.35 1486 399108175 AFP20535.1 597 5.7e-59 splicing factor 3b subunit 1 [Rhyzopertha dominica] 642934611 XM_008199516.1 94 3.70311e-39 PREDICTED: Tribolium castaneum splicing factor 3B subunit 1 (LOC660131), transcript variant X2, mRNA K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O57683 368 8.4e-34 Splicing factor 3B subunit 1 OS=Xenopus laevis GN=sf3b1 PE=2 SV=1 PF04162 Gyrovirus capsid protein (VP1) -- -- -- -- GO:0019028 viral capsid KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.30492 BP_3 159.15 1.97 4181 478257956 ENN78094.1 1229 8.4e-132 hypothetical protein YQE_05248, partial [Dendroctonus ponderosae]>gi|546676500|gb|ERL87498.1| hypothetical protein D910_04890, partial [Dendroctonus ponderosae] -- -- -- -- -- K04640 GNA guanine nucleotide-binding protein subunit alpha, other http://www.genome.jp/dbget-bin/www_bget?ko:K04640 Q05337 799 2.5e-83 Guanine nucleotide-binding protein G(f) subunit alpha OS=Drosophila melanogaster GN=Galphaf PE=2 SV=1 PF00503//PF00025//PF04670//PF07992//PF08477 G-protein alpha subunit//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Pyridine nucleotide-disulphide oxidoreductase//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0007264//GO:0055114//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//oxidation-reduction process//signal transduction GO:0004871//GO:0019001//GO:0005525//GO:0031683//GO:0016491//GO:0003924 signal transducer activity//guanyl nucleotide binding//GTP binding//G-protein beta/gamma-subunit complex binding//oxidoreductase activity//GTPase activity -- -- KOG0099 G protein subunit Galphas, small G protein superfamily Cluster-8309.30494 BP_3 172.80 2.07 4311 307173098 EFN64217.1 1138 3.1e-121 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 568 1.6e-56 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF05485//PF04977//PF13851//PF00619 THAP domain//Septum formation initiator//Growth-arrest specific micro-tubule binding//Caspase recruitment domain GO:0042981//GO:0048870//GO:0007049 regulation of apoptotic process//cell motility//cell cycle GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.30495 BP_3 2.00 2.16 327 91078028 XP_970713.1 272 6.1e-22 PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914852|ref|XP_008195047.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914854|ref|XP_008195052.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|270002305|gb|EEZ98752.1| hypothetical protein TcasGA2_TC001316 [Tribolium castaneum] -- -- -- -- -- K17218 sqr sulfide:quinone oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K17218 Q9Y6N5 205 1.5e-15 Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1 PF03402 Vomeronasal organ pheromone receptor family, V1R GO:0007186//GO:0055114//GO:0007606//GO:0019236 G-protein coupled receptor signaling pathway//oxidation-reduction process//sensory perception of chemical stimulus//response to pheromone GO:0016503//GO:0016491 pheromone receptor activity//oxidoreductase activity GO:0016021 integral component of membrane KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein Cluster-8309.30497 BP_3 330.42 4.67 3702 478257956 ENN78094.1 665 1.9e-66 hypothetical protein YQE_05248, partial [Dendroctonus ponderosae]>gi|546676500|gb|ERL87498.1| hypothetical protein D910_04890, partial [Dendroctonus ponderosae] -- -- -- -- -- K17218 sqr sulfide:quinone oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K17218 Q9R112 486 4.4e-47 Sulfide:quinone oxidoreductase, mitochondrial OS=Mus musculus GN=Sqrdl PE=1 SV=3 PF10662//PF00025//PF00503//PF08477//PF07992 Ethanolamine utilisation - propanediol utilisation//ADP-ribosylation factor family//G-protein alpha subunit//Ras of Complex, Roc, domain of DAPkinase//Pyridine nucleotide-disulphide oxidoreductase GO:0007264//GO:0055114//GO:0007186//GO:0006576//GO:0007165 small GTPase mediated signal transduction//oxidation-reduction process//G-protein coupled receptor signaling pathway//cellular biogenic amine metabolic process//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0016491//GO:0003924//GO:0005524//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//oxidoreductase activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding -- -- KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein Cluster-8309.30498 BP_3 420.00 18.52 1385 91078028 XP_970713.1 951 4.8e-100 PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914852|ref|XP_008195047.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914854|ref|XP_008195052.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|270002305|gb|EEZ98752.1| hypothetical protein TcasGA2_TC001316 [Tribolium castaneum] -- -- -- -- -- K17218 sqr sulfide:quinone oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K17218 Q9Y6N5 677 1.2e-69 Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1 PF03402//PF01266//PF05834//PF07992//PF03521//PF03529//PF00070 Vomeronasal organ pheromone receptor family, V1R//FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Kv2 voltage-gated K+ channel//Otx1 transcription factor//Pyridine nucleotide-disulphide oxidoreductase GO:0006813//GO:0007275//GO:0019236//GO:0016117//GO:0007606//GO:0055114//GO:0007186 potassium ion transport//multicellular organismal development//response to pheromone//carotenoid biosynthetic process//sensory perception of chemical stimulus//oxidation-reduction process//G-protein coupled receptor signaling pathway GO:0016491//GO:0016705//GO:0016503//GO:0005249//GO:0003700 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//pheromone receptor activity//voltage-gated potassium channel activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634//GO:0016021//GO:0008076 transcription factor complex//nucleus//integral component of membrane//voltage-gated potassium channel complex KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein Cluster-8309.305 BP_3 8.00 1.06 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30501 BP_3 22.52 0.69 1858 332373366 AEE61824.1 1459 8.0e-159 unknown [Dendroctonus ponderosae]>gi|478258142|gb|ENN78280.1| hypothetical protein YQE_05431, partial [Dendroctonus ponderosae] 391342831 XM_003745671.1 69 3.67374e-25 PREDICTED: Metaseiulus occidentalis GMP reductase 2-like (LOC100902322), mRNA K00364 E1.7.1.7, guaC GMP reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00364 Q9DCZ1 1295 3.4e-141 GMP reductase 1 OS=Mus musculus GN=Gmpr PE=2 SV=1 PF01081//PF00478//PF01070 KDPG and KHG aldolase//IMP dehydrogenase / GMP reductase domain//FMN-dependent dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0016829//GO:0003824 oxidoreductase activity//lyase activity//catalytic activity -- -- KOG2550 IMP dehydrogenase/GMP reductase Cluster-8309.30502 BP_3 18.80 1.38 948 158562470 ABW74141.1 463 1.3e-43 cuticular protein Ld-CP1v2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30503 BP_3 819.20 165.63 530 158562470 ABW74141.1 451 1.7e-42 cuticular protein Ld-CP1v2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q8T635 124 5.9e-06 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30505 BP_3 832.88 16.59 2712 332373700 AEE61991.1 1453 5.8e-158 unknown [Dendroctonus ponderosae]>gi|478250001|gb|ENN70507.1| hypothetical protein YQE_12683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 732 9.5e-76 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF01053//PF01212//PF00155 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG1368 Threonine aldolase Cluster-8309.30507 BP_3 47.12 0.64 3846 642925796 XP_008190317.1 3356 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1706 1.5e-188 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.30509 BP_3 2240.84 161.87 959 642936307 XP_008198389.1 517 7.0e-50 PREDICTED: protein FAM107B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI00 145 3.9e-08 Protein FAM107B OS=Bos taurus GN=FAM107B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30510 BP_3 126.34 3.81 1889 642936307 XP_008198389.1 506 2.6e-48 PREDICTED: protein FAM107B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H098 145 7.7e-08 Protein FAM107B OS=Homo sapiens GN=FAM107B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30513 BP_3 191.92 3.36 3042 86515428 NP_001034540.1 994 1.1e-104 protein decapentaplegic precursor [Tribolium castaneum]>gi|642921157|ref|XP_008192737.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921159|ref|XP_008192738.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921161|ref|XP_008192739.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|2501171|sp|Q26974.1|DECA_TRICA RecName: Full=Protein decapentaplegic; Flags: Precursor>gi|1458196|gb|AAB38392.1| decapentaplegic protein [Tribolium castaneum]>gi|270006465|gb|EFA02913.1| decapentaplegic [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 Q26974 994 4.5e-106 Protein decapentaplegic OS=Tribolium castaneum GN=dpp PE=3 SV=1 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity -- -- -- -- Cluster-8309.30514 BP_3 253.74 4.57 2965 91081321 XP_969973.1 585 2.8e-57 PREDICTED: CD2 antigen cytoplasmic tail-binding protein 2 homolog [Tribolium castaneum]>gi|270005202|gb|EFA01650.1| hypothetical protein TcasGA2_TC007221 [Tribolium castaneum] -- -- -- -- -- K13099 CD2BP2, PPP1R59 CD2 antigen cytoplasmic tail-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13099 Q9VKV5 482 1.0e-46 CD2 antigen cytoplasmic tail-binding protein 2 homolog OS=Drosophila melanogaster GN=holn1 PE=1 SV=1 PF02213 GYF domain -- -- GO:0005515 protein binding -- -- KOG2950 Uncharacterized protein involved in protein-protein interaction, contains polyproline-binding GYF domain Cluster-8309.30515 BP_3 117.00 3.47 1918 91078380 XP_974219.1 322 5.7e-27 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q7ZVG6 204 1.1e-14 E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1 PE=2 SV=2 PF03145 Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.3052 BP_3 7.00 0.88 673 441594244 XP_003272212.2 891 2.1e-93 PREDICTED: HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [Nomascus leucogenys]>gi|820971294|ref|XP_012358651.1| PREDICTED: HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [Nomascus leucogenys] 694915785 XM_009451001.1 628 0 PREDICTED: Pan troglodytes major histocompatibility complex, class II, DP alpha 1 (PATR-DPA1), transcript variant X2, mRNA K06752 MHC2 major histocompatibility complex, class II http://www.genome.jp/dbget-bin/www_bget?ko:K06752 P20036 785 1.7e-82 HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens GN=HLA-DPA1 PE=1 SV=1 PF00993//PF13895 Class II histocompatibility antigen, alpha domain//Immunoglobulin domain GO:0019882//GO:0006955 antigen processing and presentation//immune response GO:0005515 protein binding GO:0016020//GO:0042613 membrane//MHC class II protein complex -- -- Cluster-8309.30522 BP_3 457.58 14.44 1819 649572303 NP_001280516.1 2217 9.9e-247 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 649572302 NM_001293587.1 425 0 Tribolium castaneum V-type proton ATPase subunit H (VhaSFD), mRNA >gnl|BL_ORD_ID|19160614 Tribolium castaneum strain Georgia-1 V-type proton ATPase subunit H variant-2 (VhaSFD) mRNA, complete cds, alternatively spliced K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1591 1.6e-175 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF11698//PF00514//PF01602//PF02985 V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//HEAT repeat GO:0015992//GO:0006119//GO:0015991//GO:0006886//GO:0016192 proton transport//oxidative phosphorylation//ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle-mediated transport GO:0046961//GO:0016820//GO:0005515 proton-transporting ATPase activity, rotational mechanism//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0030117//GO:0000221 membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.30523 BP_3 796.65 31.73 1502 91092262 XP_967283.1 1903 2.1e-210 PREDICTED: methionine aminopeptidase 1 [Tribolium castaneum]>gi|270001228|gb|EEZ97675.1| hypothetical protein TcasGA2_TC016220 [Tribolium castaneum] 746858202 XM_011061556.1 236 4.32478e-118 PREDICTED: Acromyrmex echinatior methionine aminopeptidase 1 (LOC105149265), transcript variant X2, mRNA K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q4QRK0 1429 8.0e-157 Methionine aminopeptidase 1 OS=Danio rerio GN=metap1 PE=2 SV=2 -- -- GO:0009987//GO:0006508 cellular process//proteolysis GO:0046872//GO:0004177//GO:0008270//GO:0008235 metal ion binding//aminopeptidase activity//zinc ion binding//metalloexopeptidase activity -- -- KOG2738 Putative methionine aminopeptidase Cluster-8309.30527 BP_3 5.00 0.36 966 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30529 BP_3 32.90 4.79 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30531 BP_3 51.70 3.04 1112 642939241 XP_008194774.1 1159 2.9e-124 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q4JM44 411 6.5e-39 Phosphatidylcholine:ceramide cholinephosphotransferase 2 OS=Rattus norvegicus GN=Sgms2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.30532 BP_3 1180.48 9.66 6179 189242464 XP_968866.2 1250 4.6e-134 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|642939237|ref|XP_008194772.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|642939239|ref|XP_008194773.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|270016396|gb|EFA12842.1| hypothetical protein TcasGA2_TC006942 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q7T3T4 694 5.5e-71 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Gallus gallus GN=SGMS1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.30533 BP_3 118.05 0.97 6153 91090886 XP_973247.1 4721 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X1 [Tribolium castaneum]>gi|270013232|gb|EFA09680.1| hypothetical protein TcasGA2_TC011808 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 2203 5.8e-246 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0006464 protein ubiquitination//cellular protein modification process GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.30535 BP_3 69.75 1.58 2420 642919790 XP_008192068.1 687 3.4e-69 PREDICTED: uncharacterized protein LOC661416 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12162 UFM1 ubiquitin-fold modifier 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12162 Q7PXE2 319 6.6e-28 Ubiquitin-fold modifier 1 OS=Anopheles gambiae GN=AGAP001364 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3483 Uncharacterized conserved protein Cluster-8309.30537 BP_3 12.86 0.92 963 3915087 Q25009.1 1516 1.0e-165 RecName: Full=Tubulin beta-1 chain; AltName: Full=Beta-I tubulin [Homarus americanus]>gi|1272242|gb|AAC47306.1| beta-I tubulin [Homarus americanus] 1272241 U41811.1 454 0 HAU41811 Homarus americanus beta-I tubulin mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q25009 1516 4.2e-167 Tubulin beta-1 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- -- -- Cluster-8309.30538 BP_3 4.00 1.95 389 338224435 AEI88096.1 563 1.3e-55 tubulin beta-1 chain [Scylla paramamosain] 338224434 HM217863.1 337 7.51045e-175 Scylla paramamosain isolate 2 tubulin beta-1 chain mRNA, partial cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q25009 563 5.4e-57 Tubulin beta-1 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.30539 BP_3 15.00 0.84 1148 642927632 XP_008195342.1 379 8.4e-34 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q6NT99 230 6.6e-18 Dual specificity protein phosphatase 23 OS=Mus musculus GN=Dusp23 PE=2 SV=1 PF00782//PF00102//PF05706 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.30542 BP_3 335.00 4.27 4077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30544 BP_3 821.00 54.56 1017 91079114 XP_975377.1 393 1.8e-35 PREDICTED: protein lethal(2)essential for life [Tribolium castaneum]>gi|270004217|gb|EFA00665.1| hypothetical protein TcasGA2_TC003541 [Tribolium castaneum] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P02517 226 1.7e-17 Heat shock protein 26 OS=Drosophila melanogaster GN=Hsp26 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.30546 BP_3 3543.00 213.39 1092 801383453 XP_012054888.1 296 3.4e-24 PREDICTED: tubulin alpha-1 chain-like [Atta cephalotes] 837820915 XM_012928918.1 142 5.60361e-66 PREDICTED: Ochotona princeps tubulin alpha chain, testis-specific-like (LOC101519453), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q68FR8 296 1.4e-25 Tubulin alpha-3 chain OS=Rattus norvegicus GN=Tuba3a PE=2 SV=1 PF13545 Crp-like helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG1376 Alpha tubulin Cluster-8309.30548 BP_3 3.00 0.49 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30549 BP_3 723.71 16.32 2429 478257813 ENN77956.1 1797 6.7e-198 hypothetical protein YQE_05633, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 325 1.3e-28 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30550 BP_3 7.12 0.59 874 91094895 XP_973250.1 718 3.1e-73 PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923028|ref|XP_008200501.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923030|ref|XP_008200502.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- H3BPM6 258 2.8e-21 MKRN2 opposite strand protein OS=Homo sapiens GN=MKRN2OS PE=4 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.30552 BP_3 499.00 2.49 9945 642926098 XP_008194783.1 5687 0.0e+00 PREDICTED: uncharacterized protein KIAA1109 [Tribolium castaneum] 755951836 XM_011303587.1 50 7.2791e-14 PREDICTED: Fopius arisanus uncharacterized protein KIAA1109 (LOC105265834), transcript variant X9, mRNA -- -- -- -- A2AAE1 1928 7.2e-214 Uncharacterized protein KIAA1109 OS=Mus musculus GN=Kiaa1109 PE=1 SV=4 PF08093 Magi 5 toxic peptide family GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG3596 Uncharacterized conserved protein Cluster-8309.30553 BP_3 11.00 0.50 1348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30554 BP_3 20.00 156.07 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30556 BP_3 734.75 43.82 1100 478260763 ENN80436.1 851 1.5e-88 hypothetical protein YQE_03140, partial [Dendroctonus ponderosae]>gi|546683758|gb|ERL93523.1| hypothetical protein D910_10812 [Dendroctonus ponderosae] 685042175 LN590700.1 37 1.32105e-07 Cyprinus carpio genome assembly common carp genome ,scaffold LG10 K12165 UFC1 ufm1-conjugating enzyme 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12165 Q178A5 815 9.2e-86 Ubiquitin-fold modifier-conjugating enzyme 1 OS=Aedes aegypti GN=AAEL005968 PE=3 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG3357 Uncharacterized conserved protein Cluster-8309.30557 BP_3 71.15 0.34 10397 642911559 XP_970343.3 5242 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4083 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF00176//PF04851//PF03808//PF00640//PF08074//PF04689 SNF2 family N-terminal domain//Type III restriction enzyme, res subunit//Glycosyl transferase WecB/TagA/CpsF family//Phosphotyrosine interaction domain (PTB/PID)//CHDCT2 (NUC038) domain//DNA binding protein S1FA GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0008270//GO:0016818//GO:0005524//GO:0003677//GO:0016787//GO:0005515 zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//DNA binding//hydrolase activity//protein binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.30559 BP_3 939.69 23.32 2234 642918250 XP_008191430.1 2398 1.3e-267 PREDICTED: CCR4-NOT transcription complex subunit 3 [Tribolium castaneum] 780625043 XM_011709899.1 203 1.43337e-99 PREDICTED: Wasmannia auropunctata CCR4-NOT transcription complex subunit 3 (LOC105462953), mRNA K12580 CNOT3, NOT3 CCR4-NOT transcription complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12580 O75175 858 1.9e-90 CCR4-NOT transcription complex subunit 3 OS=Homo sapiens GN=CNOT3 PE=1 SV=1 PF04153//PF07352//PF04065 NOT2 / NOT3 / NOT5 family//Bacteriophage Mu Gam like protein//Not1 N-terminal domain, CCR4-Not complex component GO:0006355//GO:0042262 regulation of transcription, DNA-templated//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG2150 CCR4-NOT transcriptional regulation complex, NOT5 subunit Cluster-8309.30560 BP_3 79.59 1.43 2974 478256729 ENN76910.1 1408 1.0e-152 hypothetical protein YQE_06557, partial [Dendroctonus ponderosae]>gi|546672603|gb|ERL84404.1| hypothetical protein D910_01837 [Dendroctonus ponderosae] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 436 2.2e-41 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF04848//PF00083 Major Facilitator Superfamily//Poxvirus A22 protein//Sugar (and other) transporter GO:0006310//GO:0006281//GO:0055085 DNA recombination//DNA repair//transmembrane transport GO:0000287//GO:0016788//GO:0000400//GO:0022857 magnesium ion binding//hydrolase activity, acting on ester bonds//four-way junction DNA binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.30562 BP_3 1020.23 13.76 3866 91077466 XP_968191.1 636 4.5e-63 PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|642914015|ref|XP_008201511.1| PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|270002138|gb|EEZ98585.1| hypothetical protein TcasGA2_TC001099 [Tribolium castaneum] -- -- -- -- -- K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 Q5EB97 167 4.5e-10 Zinc finger CCHC domain-containing protein 10 OS=Rattus norvegicus GN=Zcchc10 PE=2 SV=2 PF04889//PF09726//PF00098//PF02190 Cwf15/Cwc15 cell cycle control protein//Transmembrane protein//Zinc knuckle//ATP-dependent protease La (LON) substrate-binding domain GO:0006508//GO:0006510//GO:0000398 proteolysis//obsolete ATP-dependent proteolysis//mRNA splicing, via spliceosome GO:0008270//GO:0004176//GO:0003676 zinc ion binding//ATP-dependent peptidase activity//nucleic acid binding GO:0016021//GO:0005681 integral component of membrane//spliceosomal complex KOG3116 Predicted C3H1-type Zn-finger protein Cluster-8309.30565 BP_3 1776.74 61.55 1683 91085589 XP_968685.1 1955 2.2e-216 PREDICTED: selenide, water dikinase [Tribolium castaneum]>gi|270010074|gb|EFA06522.1| hypothetical protein TcasGA2_TC009425 [Tribolium castaneum] -- -- -- -- -- K01008 selD, SEPHS selenide, water dikinase http://www.genome.jp/dbget-bin/www_bget?ko:K01008 O18373 1747 1.2e-193 Selenide, water dikinase OS=Drosophila melanogaster GN=SelD PE=2 SV=1 -- -- GO:0008152 metabolic process GO:0005524//GO:0004756 ATP binding//selenide, water dikinase activity -- -- KOG3939 Selenophosphate synthetase Cluster-8309.30566 BP_3 1277.26 20.08 3358 91085219 XP_972532.1 2370 3.3e-264 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009084|gb|EFA05532.1| hypothetical protein TcasGA2_TC015719 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 1008 1.2e-107 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05834//PF07992//PF00732//PF01266//PF05199//PF02254 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0006813//GO:0006066//GO:0006563//GO:0055114//GO:0006544//GO:0006566//GO:0016117 potassium ion transport//alcohol metabolic process//L-serine metabolic process//oxidation-reduction process//glycine metabolic process//threonine metabolic process//carotenoid biosynthetic process GO:0016491//GO:0016614//GO:0016705//GO:0050660//GO:0008812 oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding//choline dehydrogenase activity -- -- -- -- Cluster-8309.30567 BP_3 51.39 1.40 2062 478270254 ENN83480.1 344 1.7e-29 hypothetical protein YQE_00162, partial [Dendroctonus ponderosae] -- -- -- -- -- K08370 CYBRD1 cytochrome b reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08370 Q6DDR3 159 2.0e-09 Cytochrome b reductase 1 OS=Xenopus laevis GN=cybrd1 PE=2 SV=2 PF00033//PF03188 Cytochrome b/b6/petB//Eukaryotic cytochrome b561 GO:0022904 respiratory electron transport chain -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1619 Cytochrome b Cluster-8309.30568 BP_3 14.38 2.20 607 332375664 AEE62973.1 154 5.5e-08 unknown [Dendroctonus ponderosae]>gi|478254613|gb|ENN74856.1| hypothetical protein YQE_08626, partial [Dendroctonus ponderosae]>gi|546673364|gb|ERL84987.1| hypothetical protein D910_02410 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30569 BP_3 30.67 0.72 2348 189235165 XP_968097.2 1048 4.6e-111 PREDICTED: RNA polymerase-associated protein Rtf1 [Tribolium castaneum] -- -- -- -- -- K15178 RTF1 RNA polymerase-associated protein RTF1 http://www.genome.jp/dbget-bin/www_bget?ko:K15178 Q9W261 769 4.2e-80 RNA polymerase-associated protein Rtf1 OS=Drosophila melanogaster GN=Rtf1 PE=1 SV=1 PF03126 Plus-3 domain -- -- GO:0003677 DNA binding -- -- KOG2402 Paf1/RNA polymerase II complex, RTF1 component (involved in regulation of TATA box-binding protein) Cluster-8309.30570 BP_3 13.00 3.95 450 741829858 AJA91073.1 280 9.9e-23 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 243 7.9e-20 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30572 BP_3 431.00 99.18 501 91091114 XP_966512.1 340 1.2e-29 PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|91091116|ref|XP_975893.1| PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|270014090|gb|EFA10538.1| hypothetical protein TcasGA2_TC012793 [Tribolium castaneum] 645014666 XM_008205354.1 95 3.32292e-40 PREDICTED: Nasonia vitripennis GTP-binding nuclear protein Ran (LOC100114116), transcript variant X4, mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 Q9VZ23 295 8.3e-26 GTP-binding nuclear protein Ran OS=Drosophila melanogaster GN=ran PE=1 SV=1 -- -- GO:0006184//GO:0006913//GO:0006886//GO:0007264 obsolete GTP catabolic process//nucleocytoplasmic transport//intracellular protein transport//small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005622 intracellular KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-8309.30573 BP_3 207.67 3.75 2961 189234074 XP_970690.2 1301 2.7e-140 PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum]>gi|642912025|ref|XP_008199064.1| PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01785 galM, GALM aldose 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01785 Q66HG4 743 5.5e-77 Aldose 1-epimerase OS=Rattus norvegicus GN=Galm PE=1 SV=1 PF01263//PF05365 Aldose 1-epimerase//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0005975//GO:0006122 carbohydrate metabolic process//mitochondrial electron transport, ubiquinol to cytochrome c GO:0016853 isomerase activity GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane KOG1604 Predicted mutarotase Cluster-8309.30574 BP_3 323.10 11.21 1681 91081119 XP_975527.1 1499 1.7e-163 PREDICTED: lipoyl synthase, mitochondrial [Tribolium castaneum]>gi|270006027|gb|EFA02475.1| hypothetical protein TcasGA2_TC008166 [Tribolium castaneum] 675228061 LK023128.1 51 3.36432e-15 Plasmodium berghei ANKA genome assembly PBANKA01, chromosome : 13 K03644 lipA lipoic acid synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K03644 B4KYY0 1406 4.1e-154 Lipoyl synthase, mitochondrial OS=Drosophila mojavensis GN=Las PE=3 SV=1 PF04055 Radical SAM superfamily GO:0009107//GO:0009249 lipoate biosynthetic process//protein lipoylation GO:0003824//GO:0051536//GO:0016992//GO:0051539//GO:0046872 catalytic activity//iron-sulfur cluster binding//lipoate synthase activity//4 iron, 4 sulfur cluster binding//metal ion binding GO:0005739 mitochondrion KOG2672 Lipoate synthase Cluster-8309.30575 BP_3 63.25 2.12 1733 270014888 EFA11336.1 180 1.5e-10 hypothetical protein TcasGA2_TC010876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30576 BP_3 976.00 12.31 4112 641732547 XP_008156641.1 410 7.7e-37 PREDICTED: zinc finger protein 226-like [Eptesicus fuscus] -- -- -- -- -- K09215 OSR, ODD odd-skipped http://www.genome.jp/dbget-bin/www_bget?ko:K09215 Q6ZR52 402 2.7e-37 Zinc finger protein 493 OS=Homo sapiens GN=ZNF493 PE=2 SV=3 PF01428//PF13912//PF10588//PF07975//PF00096//PF13465 AN1-like Zinc finger//C2H2-type zinc finger//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281//GO:0055114 DNA repair//oxidation-reduction process GO:0008270//GO:0016491//GO:0046872 zinc ion binding//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.30577 BP_3 173.64 4.91 1995 91076406 XP_969383.1 1230 3.1e-132 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 768 4.7e-80 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.30578 BP_3 241.22 5.14 2555 91076406 XP_969383.1 1230 3.9e-132 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 768 6.0e-80 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.30579 BP_3 127.08 0.53 11888 642918833 XP_008191605.1 6388 0.0e+00 PREDICTED: myotubularin-related protein 13 isoform X4 [Tribolium castaneum]>gi|270005687|gb|EFA02135.1| hypothetical protein TcasGA2_TC007785 [Tribolium castaneum] 642918832 XM_008193383.1 1109 0 PREDICTED: Tribolium castaneum myotubularin-related protein 13 (LOC659622), transcript variant X4, mRNA K18061 SBF1_2, MTMR5_13 myotubularin-related protein 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K18061 Q86WG5 2338 2.5e-261 Myotubularin-related protein 13 OS=Homo sapiens GN=SBF2 PE=1 SV=1 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0016311 intracellular signal transduction//dephosphorylation GO:0046872//GO:0016791//GO:0005543 metal ion binding//phosphatase activity//phospholipid binding GO:0005622 intracellular KOG1090 Predicted dual-specificity phosphatase Cluster-8309.30582 BP_3 181.71 2.81 3405 642920934 XP_001814127.2 1388 2.5e-150 PREDICTED: yemanuclein-alpha isoform X2 [Tribolium castaneum] -- -- -- -- -- K17492 UBN ubinuclein http://www.genome.jp/dbget-bin/www_bget?ko:K17492 Q80WC1 453 2.7e-43 Ubinuclein-2 OS=Mus musculus GN=Ubn2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30585 BP_3 32.74 0.65 2726 91089361 XP_973125.1 1452 7.6e-158 PREDICTED: zinc finger protein 598 [Tribolium castaneum]>gi|270011436|gb|EFA07884.1| hypothetical protein TcasGA2_TC005458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFK1 789 2.4e-82 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 PF13639//PF05395//PF00096//PF01122//PF00097//PF08119 Ring finger domain//Protein phosphatase inhibitor 1/DARPP-32//Zinc finger, C2H2 type//Eukaryotic cobalamin-binding protein//Zinc finger, C3HC4 type (RING finger)//Scorpion acidic alpha-KTx toxin family GO:0015889//GO:0006810//GO:0007165//GO:0009405 cobalamin transport//transport//signal transduction//pathogenesis GO:0046872//GO:0031419//GO:0008270//GO:0005515//GO:0019870//GO:0004864 metal ion binding//cobalamin binding//zinc ion binding//protein binding//potassium channel inhibitor activity//protein phosphatase inhibitor activity GO:0005576 extracellular region KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.30589 BP_3 19.72 0.77 1520 189234116 XP_968417.2 1175 5.6e-126 PREDICTED: uridine phosphorylase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 P52624 627 8.0e-64 Uridine phosphorylase 1 OS=Mus musculus GN=Upp1 PE=1 SV=2 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3728 Uridine phosphorylase Cluster-8309.3059 BP_3 8.00 0.42 1217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30590 BP_3 34.44 0.43 4191 91090196 XP_967193.1 1917 1.4e-211 PREDICTED: cyclin-G-associated kinase [Tribolium castaneum]>gi|270013468|gb|EFA09916.1| hypothetical protein TcasGA2_TC012067 [Tribolium castaneum] -- -- -- -- -- K08855 GAK cyclin G-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08855 P97874 1662 2.1e-183 Cyclin-G-associated kinase OS=Rattus norvegicus GN=Gak PE=2 SV=1 PF07714//PF00782//PF00069 Protein tyrosine kinase//Dual specificity phosphatase, catalytic domain//Protein kinase domain GO:0006470//GO:0016310//GO:0006468 protein dephosphorylation//phosphorylation//protein phosphorylation GO:0000166//GO:0005524//GO:0008138//GO:0004672 nucleotide binding//ATP binding//protein tyrosine/serine/threonine phosphatase activity//protein kinase activity -- -- KOG1989 ARK protein kinase family Cluster-8309.30591 BP_3 661.97 35.84 1182 332372492 AEE61388.1 524 1.3e-50 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D8X2 376 7.9e-35 Coiled-coil domain-containing protein 124 OS=Mus musculus GN=Ccdc124 PE=2 SV=1 PF03552 Cellulose synthase GO:0030244//GO:0005985//GO:0005982//GO:0006011 cellulose biosynthetic process//sucrose metabolic process//starch metabolic process//UDP-glucose metabolic process GO:0016760 cellulose synthase (UDP-forming) activity GO:0016020 membrane KOG3223 Uncharacterized conserved protein Cluster-8309.30592 BP_3 477.04 6.69 3728 642929673 XP_008195930.1 1810 3.2e-199 PREDICTED: DNA methyltransferase 1-associated protein 1 [Tribolium castaneum] -- -- -- -- -- K11324 DMAP1, SWC4, EAF2 DNA methyltransferase 1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11324 Q9JI44 1178 2.5e-127 DNA methyltransferase 1-associated protein 1 OS=Mus musculus GN=Dmap1 PE=1 SV=1 PF05499 DNA methyltransferase 1-associated protein 1 (DMAP1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2656 DNA methyltransferase 1-associated protein-1 Cluster-8309.30593 BP_3 689.00 20.16 1939 642931132 XP_008201675.1 792 1.8e-81 PREDICTED: uncharacterized protein DDB_G0286299-like [Tribolium castaneum]>gi|270011877|gb|EFA08325.1| hypothetical protein TcasGA2_TC005967 [Tribolium castaneum] -- -- -- -- -- K17578 ZCCHC9 zinc finger CCHC domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K17578 Q8N567 323 1.8e-28 Zinc finger CCHC domain-containing protein 9 OS=Homo sapiens GN=ZCCHC9 PE=2 SV=2 PF00098 Zinc knuckle -- -- GO:0003676//GO:0005488//GO:0008270 nucleic acid binding//binding//zinc ion binding -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.30595 BP_3 249.00 18.37 945 91095123 XP_970890.1 871 6.1e-91 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 646 3.1e-66 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF00106//PF01073//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0008210//GO:0008152 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//estrogen metabolic process//metabolic process GO:0000166//GO:0016491//GO:0016616//GO:0003824//GO:0050662//GO:0003854 nucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- -- -- Cluster-8309.30598 BP_3 3065.38 18.52 8270 546680590 ERL90833.1 6072 0.0e+00 hypothetical protein D910_08178 [Dendroctonus ponderosae] 642925848 XM_008192328.1 61 4.64283e-20 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- Q6DFF9 2133 1.0e-237 Mitogen-activated protein kinase-binding protein 1 OS=Xenopus laevis GN=mapkbp1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1408 WD40 repeat protein Cluster-8309.30602 BP_3 19.00 0.55 1967 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30605 BP_3 7.00 0.74 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30606 BP_3 53.94 0.85 3341 642920404 XP_008192334.1 397 2.0e-35 PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum]>gi|642920406|ref|XP_967709.2| PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30607 BP_3 248.00 11.56 1326 91076178 XP_971722.1 1024 1.6e-108 PREDICTED: uncharacterized protein LOC660398 [Tribolium castaneum]>gi|270014727|gb|EFA11175.1| hypothetical protein TcasGA2_TC004782 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-8309.30608 BP_3 20.00 3.26 587 270015462 EFA11910.1 268 3.2e-21 hypothetical protein TcasGA2_TC004067 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060 Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.30609 BP_3 795.36 24.54 1854 91084337 XP_972793.1 863 1.0e-89 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 3.43956e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 559 7.5e-56 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 -- -- -- -- GO:0005515 protein binding -- -- KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.30610 BP_3 22.97 1.37 1097 642926860 XP_971810.2 259 6.6e-20 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20662 157 1.8e-09 Zinc finger Y-chromosomal protein 2 OS=Mus musculus GN=Zfy2 PE=2 SV=2 PF02150//PF13465//PF00096 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//metal ion binding GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.30611 BP_3 38.04 0.44 4442 642936291 XP_008198385.1 2574 9.7e-288 PREDICTED: nuclear pore complex protein Nup160 homolog [Tribolium castaneum] -- -- -- -- -- K14303 NUP160, NUP120 nuclear pore complex protein Nup160 http://www.genome.jp/dbget-bin/www_bget?ko:K14303 Q9VKJ3 927 3.8e-98 Nuclear pore complex protein Nup160 homolog OS=Drosophila melanogaster GN=Nup160 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30613 BP_3 29.18 0.91 1833 642914885 XP_008190430.1 598 5.4e-59 PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914887|ref|XP_008190431.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914889|ref|XP_008190432.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 333 1.2e-29 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.30615 BP_3 165.05 2.44 3558 642932799 XP_008196988.1 3582 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X2 [Tribolium castaneum]>gi|270012453|gb|EFA08901.1| hypothetical protein TcasGA2_TC006604 [Tribolium castaneum] 642932798 XM_008198766.1 304 1.64133e-155 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1786 7.6e-198 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF13639//PF00637//PF14634//PF17123//PF17122//PF00097 Ring finger domain//Region in Clathrin and VPS//zinc-RING finger domain//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger) GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005622 intracellular KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.30617 BP_3 17.11 0.60 1670 189237651 XP_001813448.1 675 5.8e-68 PREDICTED: N-acetylneuraminate lyase-like [Tribolium castaneum] -- -- -- -- -- K01639 E4.1.3.3, nanA, NPL N-acetylneuraminate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01639 Q5RDY1 336 4.9e-30 N-acetylneuraminate lyase OS=Pongo abelii GN=NPL PE=2 SV=1 PF00959//PF00701 Phage lysozyme//Dihydrodipicolinate synthetase family GO:0016998//GO:0009253//GO:0005975//GO:0008152 cell wall macromolecule catabolic process//peptidoglycan catabolic process//carbohydrate metabolic process//metabolic process GO:0003796//GO:0016829 lysozyme activity//lyase activity -- -- -- -- Cluster-8309.30618 BP_3 17.00 6.65 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30619 BP_3 46.00 13.97 450 478256535 ENN76719.1 477 1.4e-45 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NK53 223 1.7e-17 Zinc finger protein 233 OS=Homo sapiens GN=ZNF233 PE=2 SV=3 PF13895//PF13465//PF00096//PF06397//PF00628//PF04810 Immunoglobulin domain//Zinc-finger double domain//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain//PHD-finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0005506//GO:0005515//GO:0008270 metal ion binding//iron ion binding//protein binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.3062 BP_3 3.00 0.33 727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30620 BP_3 369.50 2.05 8987 642911702 XP_008200708.1 4760 0.0e+00 PREDICTED: histone-lysine N-methyltransferase trithorax [Tribolium castaneum] -- -- -- -- -- K09186 MLL1 histone-lysine N-methyltransferase MLL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09186 Q24742 1546 1.3e-169 Histone-lysine N-methyltransferase trithorax OS=Drosophila virilis GN=trx PE=3 SV=1 PF05001//PF00856//PF06221//PF00628//PF16866//PF05964//PF05965//PF00439 RNA polymerase Rpb1 C-terminal repeat//SET domain//Putative zinc finger motif, C2HC5-type//PHD-finger//PHD-finger//F/Y-rich N-terminus//F/Y rich C-terminus//Bromodomain GO:0006366//GO:0006355 transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0008270 protein binding//DNA binding//zinc ion binding GO:0005665//GO:0005634 DNA-directed RNA polymerase II, core complex//nucleus KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.30622 BP_3 37.28 1.22 1765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01701//PF01578//PF13520//PF12199 Photosystem I reaction centre subunit IX / PsaJ//Cytochrome C assembly protein//Amino acid permease//Extracellular fibrinogen binding protein C terminal GO:0017004//GO:0003333//GO:0006865//GO:0015979 cytochrome complex assembly//amino acid transmembrane transport//amino acid transport//photosynthesis GO:0020037//GO:0001848//GO:0015171 heme binding//complement binding//amino acid transmembrane transporter activity GO:0005615//GO:0016020//GO:0009522 extracellular space//membrane//photosystem I -- -- Cluster-8309.30623 BP_3 693.00 11.94 3090 328719107 XP_003246665.1 255 5.4e-19 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 462318967 APGK01044227.1 110 9.93758e-48 Dendroctonus ponderosae Seq01044237, whole genome shotgun sequence K15605 KLF3 krueppel-like factor 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15605 P15620 221 2.0e-16 Zinc finger protein 271 OS=Mus musculus GN=Znf271 PE=2 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.30624 BP_3 73.60 0.93 4102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30625 BP_3 20.67 0.31 3480 478263518 ENN81868.1 504 8.2e-48 hypothetical protein YQE_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0JZV4 262 3.9e-21 Cytosolic carboxypeptidase-like protein 5 OS=Xenopus tropicalis GN=agbl5 PE=2 SV=1 PF06638//PF05656 Strabismus protein//Protein of unknown function (DUF805) GO:0007275 multicellular organismal development -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.30626 BP_3 813.36 31.23 1547 189234028 XP_973216.2 1787 6.1e-197 PREDICTED: dual specificity mitogen-activated protein kinase kinase dSOR1 [Tribolium castaneum]>gi|270014747|gb|EFA11195.1| hypothetical protein TcasGA2_TC004803 [Tribolium castaneum] -- -- -- -- -- K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q24324 1479 1.3e-162 Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster GN=Dsor1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0581 Mitogen-activated protein kinase kinase (MAP2K) Cluster-8309.30627 BP_3 27.51 0.78 1993 478254017 ENN74309.1 1123 7.8e-120 hypothetical protein YQE_09280, partial [Dendroctonus ponderosae]>gi|546686168|gb|ERL95554.1| hypothetical protein D910_12815 [Dendroctonus ponderosae] -- -- -- -- -- K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q24324 944 1.8e-100 Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster GN=Dsor1 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0581 Mitogen-activated protein kinase kinase (MAP2K) Cluster-8309.30630 BP_3 1.00 0.41 407 642917800 XP_008191291.1 276 2.6e-22 PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|642917802|ref|XP_008191292.1| PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|270004486|gb|EFA00934.1| hypothetical protein TcasGA2_TC003840 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0PGJ6 151 3.4e-09 Aldo-keto reductase family 4 member C9 OS=Arabidopsis thaliana GN=AKR4C9 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.30634 BP_3 37.39 0.51 3814 270004551 EFA00999.1 2835 0.0e+00 hypothetical protein TcasGA2_TC003912 [Tribolium castaneum] 642918311 XM_008193232.1 116 5.67926e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1905 1.3e-211 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.30635 BP_3 55.78 2.05 1601 91086669 XP_968223.1 832 3.5e-86 PREDICTED: proteasomal ubiquitin receptor ADRM1 [Tribolium castaneum]>gi|270010393|gb|EFA06841.1| hypothetical protein TcasGA2_TC009784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K2G1 548 1.2e-54 Proteasomal ubiquitin receptor ADRM1 homolog OS=Drosophila melanogaster GN=Rpn13 PE=1 SV=1 PF04683//PF09026//PF03999//PF05460 Proteasome complex subunit Rpn13 ubiquitin receptor//Centromere protein B dimerisation domain//Microtubule associated protein (MAP65/ASE1 family)//Origin recognition complex subunit 6 (ORC6) GO:0000226//GO:0006355//GO:0006260//GO:0000910 microtubule cytoskeleton organization//regulation of transcription, DNA-templated//DNA replication//cytokinesis GO:0003682//GO:0008017//GO:0003677 chromatin binding//microtubule binding//DNA binding GO:0005737//GO:0000775//GO:0045298//GO:0005664//GO:0000785//GO:0005634 cytoplasm//chromosome, centromeric region//tubulin complex//nuclear origin of replication recognition complex//chromatin//nucleus KOG3037 Cell membrane glycoprotein Cluster-8309.30636 BP_3 675.69 6.68 5167 817052050 XP_012254225.1 1951 2.0e-215 PREDICTED: cGMP-dependent 3',5'-cyclic phosphodiesterase-like isoform X2 [Athalia rosae] -- -- -- -- -- K18283 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K18283 P14099 1564 6.1e-172 cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Bos taurus GN=PDE2A PE=1 SV=2 PF05699//PF11590//PF13185//PF00494//PF00233//PF01590//PF13492 hAT family C-terminal dimerisation region//DNA polymerase catalytic subunit Pol//GAF domain//Squalene/phytoene synthase//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain GO:0007165//GO:0006144//GO:0006260//GO:0009058//GO:0051252 signal transduction//purine nucleobase metabolic process//DNA replication//biosynthetic process//regulation of RNA metabolic process GO:0016740//GO:0004114//GO:0005515//GO:0003887//GO:0046983//GO:0004523 transferase activity//3',5'-cyclic-nucleotide phosphodiesterase activity//protein binding//DNA-directed DNA polymerase activity//protein dimerization activity//RNA-DNA hybrid ribonuclease activity GO:0042575 DNA polymerase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.30637 BP_3 19.01 0.68 1636 91086669 XP_968223.1 442 5.9e-41 PREDICTED: proteasomal ubiquitin receptor ADRM1 [Tribolium castaneum]>gi|270010393|gb|EFA06841.1| hypothetical protein TcasGA2_TC009784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q98SH3 328 4.0e-29 Proteasomal ubiquitin receptor ADRM1 OS=Gallus gallus GN=ADRM1 PE=2 SV=1 PF04683 Proteasome complex subunit Rpn13 ubiquitin receptor -- -- -- -- GO:0005634//GO:0044424//GO:0005737 nucleus//intracellular part//cytoplasm KOG3037 Cell membrane glycoprotein Cluster-8309.30639 BP_3 232.02 2.74 4377 478251314 ENN71782.1 3517 0.0e+00 hypothetical protein YQE_11516, partial [Dendroctonus ponderosae]>gi|546673516|gb|ERL85102.1| hypothetical protein D910_02524 [Dendroctonus ponderosae] -- -- -- -- -- K14569 BMS1 ribosome biogenesis protein BMS1 http://www.genome.jp/dbget-bin/www_bget?ko:K14569 Q14692 1364 8.0e-149 Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens GN=BMS1 PE=1 SV=1 PF00910//PF10662//PF00004//PF01926//PF08142 RNA helicase//Ethanolamine utilisation - propanediol utilisation//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AARP2CN (NUC121) domain GO:0006576//GO:0042254 cellular biogenic amine metabolic process//ribosome biogenesis GO:0005524//GO:0005525//GO:0003723//GO:0003724 ATP binding//GTP binding//RNA binding//RNA helicase activity GO:0005634 nucleus KOG1951 GTP-binding protein AARP2 involved in 40S ribosome biogenesis Cluster-8309.30640 BP_3 709.65 8.50 4318 478251314 ENN71782.1 3517 0.0e+00 hypothetical protein YQE_11516, partial [Dendroctonus ponderosae]>gi|546673516|gb|ERL85102.1| hypothetical protein D910_02524 [Dendroctonus ponderosae] -- -- -- -- -- K14569 BMS1 ribosome biogenesis protein BMS1 http://www.genome.jp/dbget-bin/www_bget?ko:K14569 Q14692 1364 7.9e-149 Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens GN=BMS1 PE=1 SV=1 PF00910//PF10662//PF00004//PF01926//PF08142 RNA helicase//Ethanolamine utilisation - propanediol utilisation//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AARP2CN (NUC121) domain GO:0006576//GO:0042254 cellular biogenic amine metabolic process//ribosome biogenesis GO:0003723//GO:0005525//GO:0005524//GO:0003724 RNA binding//GTP binding//ATP binding//RNA helicase activity GO:0005634 nucleus KOG1951 GTP-binding protein AARP2 involved in 40S ribosome biogenesis Cluster-8309.30641 BP_3 4.00 5.28 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30642 BP_3 10.93 0.64 1110 642935348 XP_008197977.1 417 3.2e-38 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q02157 259 2.7e-21 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30644 BP_3 15.58 0.75 1293 642927027 XP_008195109.1 719 3.6e-73 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00170 bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.30646 BP_3 185.02 3.64 2741 642927029 XP_008195110.1 1072 8.8e-114 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AY04 189 8.9e-13 Uncharacterized protein C2orf47 homolog, mitochondrial OS=Rattus norvegicus PE=2 SV=1 PF07961//PF12884//PF00170 MBA1-like protein//Transducer of regulated CREB activity, N terminus//bZIP transcription factor GO:0032979//GO:0051289//GO:0006355 protein insertion into mitochondrial membrane from inner side//protein homotetramerization//regulation of transcription, DNA-templated GO:0008140//GO:0003700//GO:0043565 cAMP response element binding protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005743 transcription factor complex//mitochondrial inner membrane -- -- Cluster-8309.30648 BP_3 426.72 5.05 4361 642918051 XP_972552.3 3722 0.0e+00 PREDICTED: uncharacterized protein LOC661288 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CXE0 285 1.0e-23 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.30649 BP_3 8.11 0.36 1373 270010675 EFA07123.1 351 1.8e-30 hypothetical protein TcasGA2_TC010114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17122//PF06807 Zinc-finger//Pre-mRNA cleavage complex II protein Clp1 GO:0031124 mRNA 3'-end processing GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.30651 BP_3 28.00 4.12 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30652 BP_3 31.97 0.48 3495 91092132 XP_975744.1 454 5.1e-42 PREDICTED: transportin-1 [Tribolium castaneum] 805820211 XM_012294805.1 58 9.07827e-19 PREDICTED: Megachile rotundata transportin-1 (LOC100876705), transcript variant X3, mRNA K18752 TNPO1 transportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K18752 Q99LG2 403 1.7e-37 Transportin-2 OS=Mus musculus GN=Tnpo2 PE=2 SV=1 PF08831 Class II MHC-associated invariant chain trimerisation domain GO:0006886//GO:0006955//GO:0019882//GO:0007165 intracellular protein transport//immune response//antigen processing and presentation//signal transduction GO:0042289 MHC class II protein binding GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) Cluster-8309.30654 BP_3 5.00 2.04 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30655 BP_3 368.52 26.30 967 546682783 ERL92672.1 487 2.1e-46 hypothetical protein D910_09984 [Dendroctonus ponderosae] 642927307 XM_008196993.1 99 3.9576e-42 PREDICTED: Tribolium castaneum hydroxysteroid (17-beta) dehydrogenase 4 (LOC663655), transcript variant X2, mRNA K12405 HSD17B4 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K12405 P97852 207 2.6e-15 Peroxisomal multifunctional enzyme type 2 OS=Rattus norvegicus GN=Hsd17b4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4170 2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/Peroxisomal 3-ketoacyl-CoA-thiolase, sterol-binding domain and related enzymes Cluster-8309.30656 BP_3 507.86 7.80 3431 91075916 XP_966441.1 3317 0.0e+00 PREDICTED: exocyst complex component 2 [Tribolium castaneum]>gi|270014638|gb|EFA11086.1| hypothetical protein TcasGA2_TC004683 [Tribolium castaneum] -- -- -- -- -- K17637 EXOC2, SEC5 exocyst complex component 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17637 Q9VQQ9 1888 1.1e-209 Exocyst complex component 2 OS=Drosophila melanogaster GN=sec5 PE=2 SV=1 PF04437//PF01833 RINT-1 / TIP-1 family//IPT/TIG domain GO:0048193 Golgi vesicle transport GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG2347 Sec5 subunit of exocyst complex Cluster-8309.30657 BP_3 86.30 0.60 7241 642911196 XP_008199563.1 2708 4.6e-303 PREDICTED: solute carrier family 12 member 4 isoform X1 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.36005e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2008 2.8e-223 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF05038//PF00324//PF03522//PF13520 Cytochrome Cytochrome b558 alpha-subunit//Amino acid permease//Solute carrier family 12//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0003333//GO:0006811 transmembrane transport//amino acid transport//transport//amino acid transmembrane transport//ion transport GO:0015171//GO:0005215//GO:0020037 amino acid transmembrane transporter activity//transporter activity//heme binding GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.30658 BP_3 23.50 1.46 1068 478251086 ENN71562.1 770 3.6e-79 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K04552 UBE2L3, UBCH7 ubiquitin-conjugating enzyme E2 L3 http://www.genome.jp/dbget-bin/www_bget?ko:K04552 Q3MHP1 685 1.1e-70 Ubiquitin-conjugating enzyme E2 L3 OS=Bos taurus GN=UBE2L3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0422 Ubiquitin-protein ligase Cluster-8309.30659 BP_3 1419.11 109.57 916 478251087 ENN71563.1 809 9.2e-84 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K04552 UBE2L3, UBCH7 ubiquitin-conjugating enzyme E2 L3 http://www.genome.jp/dbget-bin/www_bget?ko:K04552 P68036 711 8.8e-74 Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens GN=UBE2L3 PE=1 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG0422 Ubiquitin-protein ligase Cluster-8309.30660 BP_3 429.00 31.04 958 642921952 XP_008192957.1 501 5.0e-48 PREDICTED: uncharacterized protein LOC103312899 [Tribolium castaneum]>gi|642921954|ref|XP_008192958.1| PREDICTED: uncharacterized protein LOC103312899 [Tribolium castaneum]>gi|270007380|gb|EFA03828.1| hypothetical protein TcasGA2_TC013943 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30663 BP_3 874.04 8.37 5324 642935831 XP_008198194.1 4497 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 3.7e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00360//PF00621 Phytochrome region//RhoGEF domain GO:0043087//GO:0035023//GO:0009584//GO:0018298//GO:0006355 regulation of GTPase activity//regulation of Rho protein signal transduction//detection of visible light//protein-chromophore linkage//regulation of transcription, DNA-templated GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.30664 BP_3 93.27 3.11 1737 478263397 ENN81769.1 863 9.6e-90 hypothetical protein YQE_01862, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26474 259 4.3e-21 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF00041//PF13895//PF16656//PF01108 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Tissue factor GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.30666 BP_3 334.00 26.25 905 91077864 XP_972466.1 754 2.2e-77 PREDICTED: glutaredoxin-3 [Tribolium castaneum]>gi|270001471|gb|EEZ97918.1| hypothetical protein TcasGA2_TC000304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28ID3 534 2.9e-53 Glutaredoxin-3 OS=Xenopus tropicalis GN=glrx3 PE=2 SV=2 PF02966//PF05183//PF00462//PF00085 Mitosis protein DIM1//RNA dependent RNA polymerase//Glutaredoxin//Thioredoxin GO:0000398//GO:0045454//GO:0006118//GO:0006144 mRNA splicing, via spliceosome//cell redox homeostasis//obsolete electron transport//purine nucleobase metabolic process GO:0015035//GO:0009055//GO:0003968 protein disulfide oxidoreductase activity//electron carrier activity//RNA-directed RNA polymerase activity GO:0031379//GO:0005681 RNA-directed RNA polymerase complex//spliceosomal complex KOG0911 Glutaredoxin-related protein Cluster-8309.30669 BP_3 388.31 4.46 4488 91090558 XP_971487.1 1772 9.8e-195 PREDICTED: translation initiation factor eIF-2B subunit gamma [Tribolium castaneum]>gi|270013887|gb|EFA10335.1| hypothetical protein TcasGA2_TC012553 [Tribolium castaneum] 751447204 XM_011179427.1 197 6.27962e-96 PREDICTED: Bactrocera cucurbitae elongation of very long chain fatty acids protein AAEL008004 (LOC105209165), transcript variant X2, mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1017 1.4e-108 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01128//PF01151//PF07959//PF00483 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//GNS1/SUR4 family//L-fucokinase//Nucleotidyl transferase GO:0008299//GO:0009058//GO:0006694 isoprenoid biosynthetic process//biosynthetic process//steroid biosynthetic process GO:0050518//GO:0016779//GO:0016772 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups GO:0016021 integral component of membrane -- -- Cluster-8309.3067 BP_3 37.46 0.83 2464 270004641 EFA01089.1 597 9.5e-59 hypothetical protein TcasGA2_TC004012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4GZT3 243 4.4e-19 Polycystin-2 OS=Bos taurus GN=PKD2 PE=2 SV=1 PF00520//PF15050 Ion transport protein//SCIMP protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0097197//GO:0016021//GO:0016020//GO:0001772 tetraspanin-enriched microdomain//integral component of membrane//membrane//immunological synapse KOG3599 Ca2+-modulated nonselective cation channel polycystin Cluster-8309.30670 BP_3 3.34 0.55 583 332375022 AEE62652.1 276 3.7e-22 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q94519 131 1.0e-06 Acyl carrier protein, mitochondrial OS=Drosophila melanogaster GN=mtacp1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-8309.30672 BP_3 462.34 6.89 3524 646706689 KDR13796.1 370 2.9e-32 PDZ domain-containing protein 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O54824 231 1.5e-17 Pro-interleukin-16 OS=Mus musculus GN=Il16 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30673 BP_3 51.00 3.02 1105 642920140 XP_001816345.2 346 5.4e-30 PREDICTED: uncharacterized protein LOC100141670 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03376 139 2.3e-07 Balbiani ring protein 3 OS=Chironomus tentans GN=BR3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30675 BP_3 896.00 30.36 1714 189234686 XP_001811600.1 344 1.4e-29 PREDICTED: regulator of nonsense transcripts 1 [Tribolium castaneum]>gi|270002149|gb|EEZ98596.1| hypothetical protein TcasGA2_TC001115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30676 BP_3 61.71 0.32 9648 642924594 XP_008194356.1 1112 7.1e-118 PREDICTED: schwannomin-interacting protein 1-like [Tribolium castaneum]>gi|270007957|gb|EFA04405.1| hypothetical protein TcasGA2_TC014704 [Tribolium castaneum] 642924593 XM_008196134.1 241 4.70484e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.8e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 PF04647 Accessory gene regulator B GO:0009405//GO:0009372 pathogenesis//quorum sensing GO:0008233 peptidase activity GO:0016021 integral component of membrane KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.30678 BP_3 265.25 2.56 5291 642918584 XP_966986.2 1643 1.0e-179 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVD5 252 8.5e-20 Leucine-rich repeat-containing G-protein coupled receptor 6 OS=Mus musculus GN=Lgr6 PE=2 SV=1 PF07926//PF00560//PF04977//PF16331//PF10392//PF00892//PF13855//PF06005 TPR/MLP1/MLP2-like protein//Leucine Rich Repeat//Septum formation initiator//TolA binding protein trimerisation//Golgi transport complex subunit 5//EamA-like transporter family//Leucine rich repeat//Protein of unknown function (DUF904) GO:0007049//GO:0000917//GO:0043093//GO:0006606//GO:0070206//GO:0006891 cell cycle//barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//protein trimerization//intra-Golgi vesicle-mediated transport GO:0005515 protein binding GO:0005737//GO:0017119//GO:0016020//GO:0016021 cytoplasm//Golgi transport complex//membrane//integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.30680 BP_3 442.17 7.80 3025 642916733 XP_008192400.1 1772 6.6e-195 PREDICTED: homeobox protein araucan isoform X1 [Tribolium castaneum] 642916732 XM_008194178.1 767 0 PREDICTED: Tribolium castaneum homeobox protein araucan (LOC652944), transcript variant X1, mRNA -- -- -- -- Q24248 725 6.9e-75 Homeobox protein araucan OS=Drosophila melanogaster GN=ara PE=1 SV=2 PF00046//PF05920//PF00335//PF04931 Homeobox domain//Homeobox KN domain//Tetraspanin family//DNA polymerase phi GO:0006260//GO:0006351//GO:0006355 DNA replication//transcription, DNA-templated//regulation of transcription, DNA-templated GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0016021//GO:0042575 integral component of membrane//DNA polymerase complex KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.30682 BP_3 44.06 0.56 4093 189235133 XP_966882.2 2395 5.1e-267 PREDICTED: EH domain-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270003802|gb|EFA00250.1| hypothetical protein TcasGA2_TC003079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDI1 547 4.1e-54 EH domain-binding protein 1 OS=Homo sapiens GN=EHBP1 PE=1 SV=3 PF00307//PF05366 Calponin homology (CH) domain//Sarcolipin -- -- GO:0005515//GO:0030234 protein binding//enzyme regulator activity GO:0016020 membrane -- -- Cluster-8309.30683 BP_3 61.36 5.24 856 642921730 XP_008199303.1 710 2.6e-72 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 540 5.5e-54 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.30684 BP_3 30.29 0.32 4791 270005002 EFA01450.1 1248 6.0e-134 hypothetical protein TcasGA2_TC030784, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1L258 1033 2.1e-110 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF08558//PF02913 Telomere repeat binding factor (TRF)//FAD linked oxidases, C-terminal domain -- -- GO:0042162//GO:0050660//GO:0042803//GO:0003824 telomeric DNA binding//flavin adenine dinucleotide binding//protein homodimerization activity//catalytic activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.30685 BP_3 124.59 2.32 2876 642917429 XP_008191194.1 977 9.6e-103 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P84850 780 2.8e-81 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=D2hgdh PE=3 SV=1 PF01565//PF08558//PF02913 FAD binding domain//Telomere repeat binding factor (TRF)//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0042162//GO:0003824//GO:0042803//GO:0050660 oxidoreductase activity//telomeric DNA binding//catalytic activity//protein homodimerization activity//flavin adenine dinucleotide binding -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.30690 BP_3 57.01 1.04 2939 478252633 ENN73038.1 1480 4.6e-161 hypothetical protein YQE_10373, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P48594 545 5.0e-54 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30691 BP_3 637.72 13.83 2515 91089527 XP_971048.1 1743 1.3e-191 PREDICTED: protein penguin [Tribolium castaneum]>gi|270012590|gb|EFA09038.1| hypothetical protein TcasGA2_TC006751 [Tribolium castaneum] -- -- -- -- -- K14844 PUF6 pumilio homology domain family member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14844 O61345 780 2.4e-81 Protein penguin OS=Drosophila melanogaster GN=pen PE=2 SV=1 PF00651//PF08144//PF00806 BTB/POZ domain//CPL (NUC119) domain//Pumilio-family RNA binding repeat -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2050 Puf family RNA-binding protein Cluster-8309.30692 BP_3 96.65 1.18 4230 728416984 AIY68330.1 1038 1.2e-109 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 450 7.5e-43 Esterase FE4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30694 BP_3 256.31 5.56 2513 91076424 XP_976077.1 2690 1.9e-301 PREDICTED: exostosin-2 [Tribolium castaneum]>gi|270002589|gb|EEZ99036.1| hypothetical protein TcasGA2_TC004910 [Tribolium castaneum] 795266858 XM_012001352.1 75 2.30697e-28 PREDICTED: Mandrillus leucophaeus exostosin glycosyltransferase 2 (EXT2), transcript variant X2, mRNA K02367 EXT2 glucuronyl/N-acetylglucosaminyl transferase EXT2 http://www.genome.jp/dbget-bin/www_bget?ko:K02367 Q9Y169 1909 2.9e-212 Exostosin-2 OS=Drosophila melanogaster GN=Ext2 PE=1 SV=1 PF09258//PF02891 Glycosyl transferase family 64 domain//MIZ/SP-RING zinc finger GO:0015012//GO:0006024 heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process GO:0008270//GO:0016758 zinc ion binding//transferase activity, transferring hexosyl groups GO:0031227//GO:0016021 intrinsic component of endoplasmic reticulum membrane//integral component of membrane KOG1021 Acetylglucosaminyltransferase EXT1/exostosin 1 Cluster-8309.30695 BP_3 3.00 0.94 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30698 BP_3 51.71 0.31 8391 270016796 EFA13242.1 3559 0.0e+00 hypothetical protein TcasGA2_TC001512 [Tribolium castaneum] 642938255 XM_008199910.1 478 0 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O35598 1514 6.2e-166 Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus GN=Adam10 PE=1 SV=2 PF01562//PF01421 Reprolysin family propeptide//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.30699 BP_3 55.16 0.32 8483 270016796 EFA13242.1 2994 0.0e+00 hypothetical protein TcasGA2_TC001512 [Tribolium castaneum] 642938255 XM_008199910.1 393 0 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O35598 1227 1.2e-132 Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus GN=Adam10 PE=1 SV=2 PF01421//PF01562 Reprolysin (M12B) family zinc metalloprotease//Reprolysin family propeptide GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.307 BP_3 31.63 0.68 2544 642928807 XP_008195570.1 513 5.4e-49 PREDICTED: uncharacterized protein LOC103313618 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.3070 BP_3 1340.06 60.80 1354 91091644 XP_970770.1 270 4.3e-21 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000890|gb|EEZ97337.1| hypothetical protein TcasGA2_TC011149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 198 4.0e-14 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30700 BP_3 119.76 0.74 8049 649572303 NP_001280516.1 1401 1.8e-151 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 642931552 XM_961600.3 337 1.68815e-173 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1298 6.6e-141 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF02297//PF01974//PF02985//PF01602//PF00514//PF11698//PF02778 Cytochrome oxidase c subunit VIb//tRNA intron endonuclease, catalytic C-terminal domain//HEAT repeat//Adaptin N terminal region//Armadillo/beta-catenin-like repeat//V-ATPase subunit H//tRNA intron endonuclease, N-terminal domain GO:0015992//GO:0051252//GO:0006123//GO:0016192//GO:0006886//GO:0006388//GO:0006119//GO:0015991 proton transport//regulation of RNA metabolic process//mitochondrial electron transport, cytochrome c to oxygen//vesicle-mediated transport//intracellular protein transport//tRNA splicing, via endonucleolytic cleavage and ligation//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961//GO:0004129//GO:0000213//GO:0005515//GO:0016820 proton-transporting ATPase activity, rotational mechanism//cytochrome-c oxidase activity//tRNA-intron endonuclease activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0005739//GO:0000214//GO:0030117//GO:0000221//GO:0045277 mitochondrion//tRNA-intron endonuclease complex//membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain//respiratory chain complex IV KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.30702 BP_3 4778.78 40.61 5963 642917952 XP_008198956.1 1655 4.8e-181 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 728 6.1e-75 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.30703 BP_3 72.00 2.73 1564 270015258 EFA11706.1 147 9.1e-07 hypothetical protein TcasGA2_TC001793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01159 Ribosomal protein L6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.30708 BP_3 2.00 8.34 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30710 BP_3 3.00 0.94 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30711 BP_3 322.22 1.39 11441 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.70168e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF01059//PF00128//PF00069//PF04043//PF07714//PF09162 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Alpha amylase, catalytic domain//Protein kinase domain//Plant invertase/pectin methylesterase inhibitor//Protein tyrosine kinase//Tap, RNA-binding GO:0005975//GO:0055114//GO:0006120//GO:0006406//GO:0006468 carbohydrate metabolic process//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone//mRNA export from nucleus//protein phosphorylation GO:0043169//GO:0004672//GO:0005524//GO:0003824//GO:0003723//GO:0004857 cation binding//protein kinase activity//ATP binding//catalytic activity//RNA binding//enzyme inhibitor activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG3625 Alpha amylase Cluster-8309.30713 BP_3 178.95 1.15 7817 642919612 XP_008191939.1 2017 6.6e-223 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X4 [Tribolium castaneum] 642919611 XM_008193717.1 171 3.1156e-81 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.6e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF01388//PF12031//PF02257 ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518)//RFX DNA-binding domain GO:0006338//GO:0006355 chromatin remodeling//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0090544 BAF-type complex -- -- Cluster-8309.30714 BP_3 485.00 8.68 2986 189240234 XP_968546.2 3226 0.0e+00 PREDICTED: roquin-1 [Tribolium castaneum] 571504095 XM_006569527.1 254 8.57185e-128 PREDICTED: Apis mellifera roquin (roq), mRNA K15690 RC3H RING finger and CCCH-type zinc finger domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K15690 Q4VGL6 1584 1.7e-174 Roquin-1 OS=Mus musculus GN=Rc3h1 PE=1 SV=1 PF16685//PF13639//PF00097//PF05138//PF14634//PF00642 zinc RING finger of MSL2//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Phenylacetic acid catabolic protein//zinc-RING finger domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0010124 phenylacetate catabolic process GO:0008270//GO:0061630//GO:0046872//GO:0005515 zinc ion binding//ubiquitin protein ligase activity//metal ion binding//protein binding -- -- KOG3161 Predicted E3 ubiquitin ligase Cluster-8309.30716 BP_3 15.00 1.11 946 642931814 XP_008196744.1 982 8.3e-104 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 761 1.4e-79 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30717 BP_3 57.00 0.61 4792 86604731 NP_001034510.1 1110 6.0e-118 transcription factor deformed [Tribolium castaneum]>gi|13241682|gb|AAK16423.1|AF321227_3 Dfd [Tribolium castaneum]>gi|1754686|gb|AAB39355.1| transcription factor Deformed [Tribolium castaneum]>gi|270002806|gb|EEZ99253.1| deformed [Tribolium castaneum] 676432024 XM_009048192.1 82 5.68549e-32 Lottia gigantea hypothetical protein partial mRNA K09304 HOX_4 homeobox protein HoxA/B/C/D4 http://www.genome.jp/dbget-bin/www_bget?ko:K09304 P07548 503 6.0e-49 Homeotic protein deformed OS=Drosophila melanogaster GN=Dfd PE=1 SV=2 PF07244//PF00046 Surface antigen variable number repeat//Homeobox domain -- -- GO:0003677 DNA binding GO:0019867 outer membrane -- -- Cluster-8309.30719 BP_3 92.00 4.87 1203 642913811 XP_008201169.1 727 3.9e-74 PREDICTED: paired mesoderm homeobox protein 2 [Tribolium castaneum]>gi|270002762|gb|EEZ99209.1| hypothetical protein TcasGA2_TC000527 [Tribolium castaneum] -- -- -- -- -- K09329 PRRX, PMX paired mesoderm homeobox protein http://www.genome.jp/dbget-bin/www_bget?ko:K09329 P54821 294 2.6e-25 Paired mesoderm homeobox protein 1 OS=Homo sapiens GN=PRRX1 PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.30721 BP_3 1217.00 59.06 1285 642932726 XP_971981.2 749 1.2e-76 PREDICTED: EF-hand domain-containing protein D2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VJ26 523 7.8e-52 EF-hand domain-containing protein D2 homolog OS=Drosophila melanogaster GN=Swip-1 PE=2 SV=1 PF12763//PF13202//PF13499//PF10591//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0041 Predicted Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.30722 BP_3 82.92 1.59 2800 642911817 XP_008200757.1 2573 8.0e-288 PREDICTED: histone-arginine methyltransferase CARMER isoform X1 [Tribolium castaneum]>gi|270014548|gb|EFA10996.1| hypothetical protein TcasGA2_TC004581 [Tribolium castaneum] -- -- -- -- -- K05931 CARM1, PRMT4 histone-arginine methyltransferase CARM1 http://www.genome.jp/dbget-bin/www_bget?ko:K05931 Q174R2 1725 7.1e-191 Histone-arginine methyltransferase CARMER OS=Aedes aegypti GN=CARM1 PE=3 SV=1 PF06484//PF05175//PF08241//PF02932//PF03602//PF03153//PF09606//PF05185 Teneurin Intracellular Region//Methyltransferase small domain//Methyltransferase domain//Neurotransmitter-gated ion-channel transmembrane region//Conserved hypothetical protein 95//Transcription factor IIA, alpha/beta subunit//ARC105 or Med15 subunit of Mediator complex non-fungal//PRMT5 arginine-N-methyltransferase GO:0008152//GO:0007165//GO:0031167//GO:0006479//GO:0006357//GO:0006811//GO:0006367 metabolic process//signal transduction//rRNA methylation//protein methylation//regulation of transcription from RNA polymerase II promoter//ion transport//transcription initiation from RNA polymerase II promoter GO:0001104//GO:0008168 RNA polymerase II transcription cofactor activity//methyltransferase activity GO:0016021//GO:0016592//GO:0016020//GO:0005672 integral component of membrane//mediator complex//membrane//transcription factor TFIIA complex KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.30725 BP_3 34.30 0.32 5448 91089283 XP_970929.1 506 7.5e-48 PREDICTED: protein phosphatase PTC7 homolog [Tribolium castaneum]>gi|270012497|gb|EFA08945.1| hypothetical protein TcasGA2_TC006652 [Tribolium castaneum] 768444891 XM_011566017.1 92 1.78613e-37 PREDICTED: Plutella xylostella protein phosphatase PTC7 homolog (LOC105394173), mRNA -- -- -- -- Q5U3N5 348 6.5e-31 Protein phosphatase PTC7 homolog OS=Danio rerio GN=pptc7 PE=2 SV=1 PF00481//PF07228 Protein phosphatase 2C//Stage II sporulation protein E (SpoIIE) GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1379 Serine/threonine protein phosphatase Cluster-8309.30727 BP_3 49.49 0.89 2974 332373670 AEE61976.1 400 8.0e-36 unknown [Dendroctonus ponderosae]>gi|478257673|gb|ENN77820.1| hypothetical protein YQE_05704, partial [Dendroctonus ponderosae] -- -- -- -- -- K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q8BNI4 334 1.5e-29 Derlin-2 OS=Mus musculus GN=Derl2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0858 Predicted membrane protein Cluster-8309.30730 BP_3 19.26 1.70 838 642915229 XP_008190531.1 250 5.6e-19 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 158 1.1e-09 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30732 BP_3 28.11 1.06 1575 91087093 XP_975012.1 944 3.5e-99 PREDICTED: hydroxylysine kinase [Tribolium castaneum]>gi|270009602|gb|EFA06050.1| hypothetical protein TcasGA2_TC008883 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2RU49 521 1.6e-51 Hydroxylysine kinase OS=Homo sapiens GN=HYKK PE=1 SV=2 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.30733 BP_3 292.89 12.32 1438 91087093 XP_975012.1 944 3.2e-99 PREDICTED: hydroxylysine kinase [Tribolium castaneum]>gi|270009602|gb|EFA06050.1| hypothetical protein TcasGA2_TC008883 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2RU49 521 1.5e-51 Hydroxylysine kinase OS=Homo sapiens GN=HYKK PE=1 SV=2 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.30737 BP_3 15.00 0.36 2284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30738 BP_3 3.06 0.40 661 270010687 EFA07135.1 308 8.3e-26 hypothetical protein TcasGA2_TC010126 [Tribolium castaneum] -- -- -- -- -- K01974 RTCA, rtcA RNA 3'-terminal phosphate cyclase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K01974 Q9D7H3 208 1.3e-15 RNA 3'-terminal phosphate cyclase OS=Mus musculus GN=RtcA PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30740 BP_3 126.00 5.52 1392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30742 BP_3 23.55 0.38 3271 817199200 XP_012275275.1 876 5.6e-91 PREDICTED: 4-hydroxyphenylpyruvate dioxygenase [Orussus abietinus] -- -- -- -- -- K00457 HPD, hppD 4-hydroxyphenylpyruvate dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00457 P32755 766 1.3e-79 4-hydroxyphenylpyruvate dioxygenase OS=Rattus norvegicus GN=Hpd PE=1 SV=3 PF00631//PF02050 GGL domain//Flagellar FliJ protein GO:0007186//GO:0006935//GO:0007165//GO:0071973 G-protein coupled receptor signaling pathway//chemotaxis//signal transduction//bacterial-type flagellum-dependent cell motility GO:0003774//GO:0004871 motor activity//signal transducer activity GO:0016020//GO:0009288//GO:0005834 membrane//bacterial-type flagellum//heterotrimeric G-protein complex KOG0638 4-hydroxyphenylpyruvate dioxygenase Cluster-8309.30743 BP_3 35.05 0.55 3367 355785806 EHH65989.1 174 1.5e-09 hypothetical protein EGM_02875, partial [Macaca fascicularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30744 BP_3 49.23 2.15 1394 478250865 ENN71354.1 245 3.5e-18 hypothetical protein YQE_11969, partial [Dendroctonus ponderosae] -- -- -- -- -- K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 Q29I35 212 9.7e-16 Armadillo segment polarity protein OS=Drosophila pseudoobscura pseudoobscura GN=arm PE=3 SV=2 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.30746 BP_3 6.89 0.42 1084 642931814 XP_008196744.1 1235 4.4e-133 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 884 9.0e-94 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF06584//PF00067 DIRP//Cytochrome P450 GO:0006351//GO:0055114//GO:0007049 transcription, DNA-templated//oxidation-reduction process//cell cycle GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding GO:0017053 transcriptional repressor complex -- -- Cluster-8309.30747 BP_3 2060.38 16.47 6321 780653487 XP_011691003.1 1653 8.7e-181 PREDICTED: pescadillo homolog [Wasmannia auropunctata] 704508966 XM_010081703.1 86 4.48784e-34 PREDICTED: Pterocles gutturalis pelota homolog (Drosophila) (PELO), mRNA K06965 PELO, DOM34, pelA protein pelota http://www.genome.jp/dbget-bin/www_bget?ko:K06965 P48612 1549 4.1e-170 Protein pelota OS=Drosophila melanogaster GN=pelo PE=2 SV=2 PF06732 Pescadillo N-terminus GO:0042254 ribosome biogenesis -- -- GO:0005730 nucleolus KOG2869 Meiotic cell division protein Pelota/DOM34 Cluster-8309.30748 BP_3 277.89 2.42 5816 546671147 ERL83597.1 1894 9.0e-209 hypothetical protein D910_00703 [Dendroctonus ponderosae]>gi|546674557|gb|ERL85913.1| hypothetical protein D910_03328 [Dendroctonus ponderosae] 704508966 XM_010081703.1 62 9.06551e-21 PREDICTED: Pterocles gutturalis pelota homolog (Drosophila) (PELO), mRNA K14843 PES1, NOP7 pescadillo http://www.genome.jp/dbget-bin/www_bget?ko:K14843 B4KID9 1462 4.6e-160 Pescadillo homolog OS=Drosophila mojavensis GN=GI18209 PE=3 SV=1 PF06732 Pescadillo N-terminus GO:0042254 ribosome biogenesis -- -- GO:0005730 nucleolus KOG2481 Protein required for normal rRNA processing Cluster-8309.30749 BP_3 460.17 6.81 3549 91084469 XP_970666.1 1416 1.5e-153 PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925528|ref|XP_008194588.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925531|ref|XP_008194589.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum] 817200928 XM_012420774.1 171 1.40727e-81 PREDICTED: Orussus abietinus transcription factor Sp1-like (LOC105697447), transcript variant X5, mRNA -- -- -- -- P18722 282 1.9e-23 Gastrula zinc finger protein XlCGF46.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF00096//PF13465//PF13912//PF05191 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Adenylate kinase, active site lid GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0046872//GO:0004017 metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.30753 BP_3 115.69 2.41 2607 300303952 ADJ97385.1 1183 1.1e-126 star [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42519 539 2.2e-53 Protein Star OS=Drosophila melanogaster GN=S PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30754 BP_3 898.52 38.49 1417 642923427 XP_008193740.1 1289 3.1e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6JFQ6 393 1.0e-36 Clavesin-1 OS=Rattus norvegicus GN=Clvs1 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.30755 BP_3 806.72 68.18 862 211939884 ACJ13424.1 598 2.5e-59 serpin [Sphenophorus levis] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 426 9.2e-41 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.30756 BP_3 689.28 35.22 1235 211939884 ACJ13424.1 598 3.6e-59 serpin [Sphenophorus levis] -- -- -- -- -- -- -- -- -- P22922 426 1.3e-40 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.30759 BP_3 97.71 1.72 3033 134131322 BAF49604.1 893 5.6e-93 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 490 1.2e-47 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00089//PF00704 Trypsin//Glycosyl hydrolases family 18 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004252//GO:0004553 serine-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.30761 BP_3 119.93 0.77 7751 478261414 ENN80791.1 4569 0.0e+00 hypothetical protein YQE_02800, partial [Dendroctonus ponderosae]>gi|546680987|gb|ERL91161.1| hypothetical protein D910_08501 [Dendroctonus ponderosae] 815771795 XM_012380628.1 476 0 PREDICTED: Linepithema humile ATP-dependent helicase brm (LOC105680160), mRNA K11647 SMARCA2_4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K11647 Q3TKT4 3297 0.0e+00 Transcription activator BRG1 OS=Mus musculus GN=Smarca4 PE=1 SV=1 PF08880//PF00439//PF14619//PF07533//PF00069//PF00270//PF04851//PF00176 QLQ//Bromodomain//Snf2-ATP coupling, chromatin remodelling complex//BRK domain//Protein kinase domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain GO:0006468//GO:0006355 protein phosphorylation//regulation of transcription, DNA-templated GO:0003677//GO:0016787//GO:0005524//GO:0005515//GO:0042393//GO:0003676//GO:0004672//GO:0016817 DNA binding//hydrolase activity//ATP binding//protein binding//histone binding//nucleic acid binding//protein kinase activity//hydrolase activity, acting on acid anhydrides GO:0005634 nucleus KOG0386 Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) Cluster-8309.30763 BP_3 647.29 11.27 3059 91079058 XP_975148.1 1112 2.3e-118 PREDICTED: ubiquitin domain-containing protein UBFD1 isoform X2 [Tribolium castaneum]>gi|270004196|gb|EFA00644.1| hypothetical protein TcasGA2_TC003520 [Tribolium castaneum] 769860810 XM_011643855.1 58 7.93397e-19 PREDICTED: Pogonomyrmex barbatus ubiquitin domain-containing protein UBFD1-like (LOC105430337), transcript variant X3, mRNA -- -- -- -- Q78JW9 727 4.1e-75 Ubiquitin domain-containing protein UBFD1 OS=Mus musculus GN=Ubfd1 PE=1 SV=2 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG3289 Uncharacterized conserved protein encoded by sequence overlapping the COX4 gene Cluster-8309.30766 BP_3 37.16 0.91 2254 91076316 XP_969753.1 695 3.8e-70 PREDICTED: xylulose kinase [Tribolium castaneum]>gi|270002483|gb|EEZ98930.1| hypothetical protein TcasGA2_TC004550 [Tribolium castaneum] -- -- -- -- -- K00854 xylB, XYLB xylulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00854 O75191 451 3.0e-43 Xylulose kinase OS=Homo sapiens GN=XYLB PE=1 SV=3 PF02782 FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2531 Sugar (pentulose and hexulose) kinases Cluster-8309.30768 BP_3 90.08 10.11 721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3077 BP_3 60.27 2.07 1695 642936411 XP_972396.2 620 1.4e-61 PREDICTED: zinc finger protein 714 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A2VDP4 326 7.1e-29 Zinc finger protein 567 OS=Bos taurus GN=ZNF567 PE=2 SV=1 PF00649//PF07776//PF00096//PF13912//PF04810//PF02892//PF16622//PF13465 Copper fist DNA binding domain//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc-finger double domain GO:0006355//GO:0006888//GO:0006886 regulation of transcription, DNA-templated//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0003700//GO:0046872//GO:0003677//GO:0005507 zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//DNA binding//copper ion binding GO:0005634//GO:0030127//GO:0005667 nucleus//COPII vesicle coat//transcription factor complex -- -- Cluster-8309.30771 BP_3 62.08 1.34 2528 478260276 ENN80028.1 271 6.2e-21 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2EI20 183 4.1e-12 RE1-silencing transcription factor OS=Danio rerio GN=rest PE=2 SV=1 PF02150//PF00096//PF13465//PF04988//PF03348//PF06309//PF07649 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//Serine incorporator (Serinc)//Torsin//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0005524//GO:0003899//GO:0003677//GO:0046872//GO:0047134 ATP binding//DNA-directed RNA polymerase activity//DNA binding//metal ion binding//protein-disulfide reductase activity GO:0005634//GO:0005730//GO:0016020 nucleus//nucleolus//membrane KOG1721 FOG: Zn-finger Cluster-8309.30772 BP_3 664.72 18.37 2036 332372963 AEE61623.1 1106 7.5e-118 unknown [Dendroctonus ponderosae]>gi|478254924|gb|ENN75158.1| hypothetical protein YQE_08271, partial [Dendroctonus ponderosae]>gi|546673351|gb|ERL84977.1| hypothetical protein D910_02400 [Dendroctonus ponderosae] 195122951 XM_002005938.1 132 3.83762e-60 Drosophila mojavensis GI20775 (Dmoj\GI20775), mRNA -- -- -- -- Q28Y69 882 2.9e-93 Zinc finger CCCH domain-containing protein 15 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA21225 PE=3 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- KOG1763 Uncharacterized conserved protein, contains CCCH-type Zn-finger Cluster-8309.30773 BP_3 54.00 2.90 1188 478255831 ENN76039.1 889 6.3e-93 hypothetical protein YQE_07412, partial [Dendroctonus ponderosae] -- -- -- -- -- K15456 KTI12 protein KTI12 http://www.genome.jp/dbget-bin/www_bget?ko:K15456 Q0P457 497 7.4e-49 Protein KTI12 homolog OS=Danio rerio GN=kti12 PE=2 SV=2 PF00437//PF01591//PF01583 Type II/IV secretion system protein//6-phosphofructo-2-kinase//Adenylylsulphate kinase GO:0006144//GO:0000103//GO:0006810//GO:0006013//GO:0006000 purine nucleobase metabolic process//sulfate assimilation//transport//mannose metabolic process//fructose metabolic process GO:0005524//GO:0003873//GO:0004020 ATP binding//6-phosphofructo-2-kinase activity//adenylylsulfate kinase activity -- -- KOG3062 RNA polymerase II elongator associated protein Cluster-8309.30774 BP_3 402.00 18.29 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30775 BP_3 326.74 3.38 4946 270007830 EFA04278.1 3034 0.0e+00 hypothetical protein TcasGA2_TC014568 [Tribolium castaneum] 642924109 XM_008195787.1 538 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1466 1.3e-160 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF07714//PF00069//PF06293//PF07463 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//NUMOD4 motif GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016788//GO:0016773 protein kinase activity//ATP binding//hydrolase activity, acting on ester bonds//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.30778 BP_3 1385.19 7.64 9033 270006069 EFA02517.1 3497 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 703 0 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 Q92793 2346 2.2e-262 CREB-binding protein OS=Homo sapiens GN=CREBBP PE=1 SV=3 PF02135//PF09030//PF08214//PF16987//PF02172//PF06371//PF09468//PF00569//PF07711//PF12437//PF00439 TAZ zinc finger//Creb binding//Histone acetylation protein//KIX domain//KIX domain//Diaphanous GTPase-binding Domain//Ydr279p protein family (RNase H2 complex component)//Zinc finger, ZZ type//Rab geranylgeranyl transferase alpha-subunit, insert domain//Glutamine synthetase type III N terminal//Bromodomain GO:0009252//GO:0006807//GO:0030036//GO:0006355//GO:0042967//GO:0016573 peptidoglycan biosynthetic process//nitrogen compound metabolic process//actin cytoskeleton organization//regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process//histone acetylation GO:0017048//GO:0004402//GO:0005515//GO:0003713//GO:0004356//GO:0004663//GO:0003712//GO:0008270//GO:0003779 Rho GTPase binding//histone acetyltransferase activity//protein binding//transcription coactivator activity//glutamate-ammonia ligase activity//Rab geranylgeranyltransferase activity//transcription cofactor activity//zinc ion binding//actin binding GO:0000123//GO:0005968//GO:0005667//GO:0005634 histone acetyltransferase complex//Rab-protein geranylgeranyltransferase complex//transcription factor complex//nucleus KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.30780 BP_3 1525.09 23.37 3437 91078836 XP_971451.1 1905 2.8e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 1.81296e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.4e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0005975//GO:0006508//GO:0008152 carbohydrate metabolic process//proteolysis//metabolic process GO:0016805//GO:0008237//GO:0034701//GO:0016787//GO:0004560 dipeptidase activity//metallopeptidase activity//tripeptidase activity//hydrolase activity//alpha-L-fucosidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.30782 BP_3 26.17 0.69 2121 189241276 XP_974567.2 911 3.2e-95 PREDICTED: guanine nucleotide-binding protein-like 3 homolog [Tribolium castaneum]>gi|270014031|gb|EFA10479.1| hypothetical protein TcasGA2_TC012725 [Tribolium castaneum] -- -- -- -- -- K14538 NUG1, GNL3 nuclear GTP-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14538 Q8MT06 685 2.1e-70 Guanine nucleotide-binding protein-like 3 homolog OS=Drosophila melanogaster GN=Ns1 PE=1 SV=2 PF00025//PF02421//PF01926//PF08692//PF03193//PF08477 ADP-ribosylation factor family//Ferrous iron transport protein B//50S ribosome-binding GTPase//Mitochondrial protein Pet20//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0015093//GO:0003924 GTP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021//GO:0005739 integral component of membrane//mitochondrion KOG2484 GTPase Cluster-8309.30785 BP_3 15.00 4.96 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30786 BP_3 728.95 7.26 5129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30788 BP_3 5.00 3.56 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30789 BP_3 18.64 0.52 2035 91080597 XP_973963.1 1403 2.7e-152 PREDICTED: vacuolar protein-sorting-associated protein 36 [Tribolium castaneum]>gi|270005813|gb|EFA02261.1| hypothetical protein TcasGA2_TC007925 [Tribolium castaneum] -- -- -- -- -- K12190 VPS36, EAP45 ESCRT-II complex subunit VPS36 http://www.genome.jp/dbget-bin/www_bget?ko:K12190 Q9VU87 927 1.8e-98 Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0032266//GO:0043130 phosphatidylinositol-3-phosphate binding//ubiquitin binding -- -- KOG2760 Vacuolar sorting protein VPS36 Cluster-8309.30792 BP_3 782.48 7.22 5515 478258247 ENN78376.1 8921 0.0e+00 hypothetical protein YQE_05177, partial [Dendroctonus ponderosae] 642938178 XM_961838.2 1843 0 PREDICTED: Tribolium castaneum pre-mRNA-processing-splicing factor 8 (LOC655310), mRNA K12856 PRPF8, PRP8 pre-mRNA-processing factor 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12856 Q6P2Q9 8605 0.0e+00 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens GN=PRPF8 PE=1 SV=2 PF01398//PF08083//PF10596//PF10147//PF10597//PF10598 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//PROCN (NUC071) domain//U6-snRNA interacting domain of PrP8//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//U5-snRNA binding site 2 of PrP8//RNA recognition motif of the spliceosomal PrP8 GO:0007049//GO:0000398 cell cycle//mRNA splicing, via spliceosome GO:0003723//GO:0017070//GO:0030623//GO:0005515 RNA binding//U6 snRNA binding//U5 snRNA binding//protein binding GO:0005634 nucleus KOG1795 U5 snRNP spliceosome subunit Cluster-8309.30793 BP_3 144.47 2.88 2707 91084685 XP_968610.1 2003 9.6e-222 PREDICTED: uncharacterized protein CG3556 [Tribolium castaneum]>gi|270008929|gb|EFA05377.1| hypothetical protein TcasGA2_TC015544 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W4K2 1115 3.7e-120 Uncharacterized protein CG3556 OS=Drosophila melanogaster GN=CG3556 PE=2 SV=1 PF07678//PF00983//PF01122//PF00432 A-macroglobulin complement component//Tymovirus coat protein//Eukaryotic cobalamin-binding protein//Prenyltransferase and squalene oxidase repeat GO:0015889 cobalamin transport GO:0003824//GO:0031419//GO:0005198 catalytic activity//cobalamin binding//structural molecule activity GO:0019028//GO:0005615 viral capsid//extracellular space -- -- Cluster-8309.30794 BP_3 31.53 2.12 1010 91084685 XP_968610.1 1182 5.7e-127 PREDICTED: uncharacterized protein CG3556 [Tribolium castaneum]>gi|270008929|gb|EFA05377.1| hypothetical protein TcasGA2_TC015544 [Tribolium castaneum] -- -- -- -- -- K14615 GIF, IF gastric intrinsic factor http://www.genome.jp/dbget-bin/www_bget?ko:K14615 Q9W4K2 600 7.2e-61 Uncharacterized protein CG3556 OS=Drosophila melanogaster GN=CG3556 PE=2 SV=1 PF07678//PF00983//PF00432//PF01122 A-macroglobulin complement component//Tymovirus coat protein//Prenyltransferase and squalene oxidase repeat//Eukaryotic cobalamin-binding protein GO:0015889 cobalamin transport GO:0005198//GO:0031419//GO:0003824 structural molecule activity//cobalamin binding//catalytic activity GO:0005615//GO:0019028 extracellular space//viral capsid -- -- Cluster-8309.30795 BP_3 75.85 1.18 3390 642914172 XP_008201574.1 2030 8.9e-225 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 826 1.5e-86 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF15182//PF01738 Otospiralin//Dienelactone hydrolase family GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.30796 BP_3 32.49 0.60 2903 642914172 XP_008201574.1 1663 2.8e-182 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 574 2.1e-57 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF15182//PF01738 Otospiralin//Dienelactone hydrolase family GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.30798 BP_3 43.83 0.56 4068 820805580 AKG92781.1 3212 0.0e+00 trachealess [Leptinotarsa decemlineata] 820805579 KP147944.1 644 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1107 4.7e-119 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF00010//PF04551//PF08447//PF00989 Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold//PAS fold GO:0006355//GO:0016114//GO:0055114 regulation of transcription, DNA-templated//terpenoid biosynthetic process//oxidation-reduction process GO:0046983//GO:0005515//GO:0046429 protein dimerization activity//protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity -- -- -- -- Cluster-8309.308 BP_3 30.19 0.86 1982 642928807 XP_008195570.1 330 7.0e-28 PREDICTED: uncharacterized protein LOC103313618 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.30803 BP_3 133.91 1.48 4656 91088399 XP_972896.1 2473 5.2e-276 PREDICTED: rap1 GTPase-activating protein 1 isoform X2 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.52475e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 4.1e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF13851//PF02188//PF07836//PF02145 Growth-arrest specific micro-tubule binding//GoLoco motif//DmpG-like communication domain//Rap/ran-GAP GO:0048870//GO:0051056//GO:0019439 cell motility//regulation of small GTPase mediated signal transduction//aromatic compound catabolic process GO:0016833//GO:0030695//GO:0005096 oxo-acid-lyase activity//GTPase regulator activity//GTPase activator activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.30804 BP_3 553.27 5.11 5510 642918562 XP_008199292.1 1526 4.0e-166 PREDICTED: large proline-rich protein BAG6 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH17 362 1.6e-32 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF07469//PF00240//PF14560 Domain of unknown function (DUF1518)//Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4248 Ubiquitin-like protein, regulator of apoptosis Cluster-8309.30809 BP_3 42.00 0.75 3006 -- -- -- -- -- 462464129 APGK01005035.1 75 2.76414e-28 Dendroctonus ponderosae Seq01005037, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30810 BP_3 494.65 6.50 3958 91078836 XP_971451.1 1905 3.3e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 2.09069e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.6e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0006508//GO:0005975//GO:0008152 proteolysis//carbohydrate metabolic process//metabolic process GO:0008237//GO:0016805//GO:0004560//GO:0016787//GO:0034701 metallopeptidase activity//dipeptidase activity//alpha-L-fucosidase activity//hydrolase activity//tripeptidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.30811 BP_3 502.99 42.59 861 91087767 XP_975031.1 1032 1.2e-109 PREDICTED: vacuolar protein sorting-associated protein 28 homolog [Tribolium castaneum]>gi|270010745|gb|EFA07193.1| hypothetical protein TcasGA2_TC010199 [Tribolium castaneum] -- -- -- -- -- K12184 VPS28 ESCRT-I complex subunit VPS28 http://www.genome.jp/dbget-bin/www_bget?ko:K12184 Q9V359 850 6.3e-90 Vacuolar protein sorting-associated protein 28 homolog OS=Drosophila melanogaster GN=Vps28 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3284 Vacuolar sorting protein VPS28 Cluster-8309.30812 BP_3 1.00 1.46 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30813 BP_3 6.15 0.61 780 73921478 AAZ94269.1 218 2.7e-15 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 169 5.3e-11 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.30814 BP_3 352.51 8.86 2210 731286412 XP_010611509.1 690 1.4e-69 PREDICTED: LOW QUALITY PROTEIN: histone H3.3 [Fukomys damarensis] 805824145 XM_003708049.2 153 8.83973e-72 PREDICTED: Megachile rotundata histone H3.3 (LOC100883938), mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 Q6P823 676 2.4e-69 Histone H3.3 OS=Xenopus tropicalis GN=TGas113e22.1 PE=1 SV=3 PF00125//PF15715//PF08219 Core histone H2A/H2B/H3/H4//PCNA-associated factor//Outer membrane protein TOM13 GO:0006974//GO:0051726 cellular response to DNA damage stimulus//regulation of cell cycle GO:0003677 DNA binding GO:0005741 mitochondrial outer membrane KOG1745 Histones H3 and H4 Cluster-8309.30815 BP_3 36.85 3.49 800 642931814 XP_008196744.1 829 3.9e-86 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 546 1.0e-54 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.30816 BP_3 48.25 2.56 1200 741829858 AJA91073.1 806 2.7e-83 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 517 3.6e-51 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF08127 Cytochrome P450//Peptidase family C1 propeptide GO:0050790//GO:0055114//GO:0006508 regulation of catalytic activity//oxidation-reduction process//proteolysis GO:0005506//GO:0004197//GO:0020037//GO:0016705 iron ion binding//cysteine-type endopeptidase activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30817 BP_3 945.62 60.51 1045 189236526 XP_975464.2 474 7.4e-45 PREDICTED: spondin-1 [Tribolium castaneum]>gi|270005305|gb|EFA01753.1| hypothetical protein TcasGA2_TC007351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 143 7.3e-08 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 -- -- -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.30818 BP_3 209.61 1.81 5865 270004045 EFA00493.1 1898 3.1e-209 hypothetical protein TcasGA2_TC003353 [Tribolium castaneum] 642915649 XM_967018.2 68 4.22354e-24 PREDICTED: Tribolium castaneum tyrosine-protein kinase-like otk (LOC660815), mRNA K05127 PTK7, CCK4 PTK7 protein tyrosine kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05127 B4GBH0 1000 1.7e-106 Tyrosine-protein kinase-like otk OS=Drosophila persimilis GN=otk PE=3 SV=1 PF13895//PF00069//PF01135//PF07714 Immunoglobulin domain//Protein kinase domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Protein tyrosine kinase GO:0046500//GO:0006479//GO:0006468//GO:0006464 S-adenosylmethionine metabolic process//protein methylation//protein phosphorylation//cellular protein modification process GO:0004672//GO:0004719//GO:0005515//GO:0005524 protein kinase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.30819 BP_3 74.96 1.08 3644 478252006 ENN72441.1 2780 0.0e+00 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1406 9.0e-154 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF05173//PF01433 Dihydrodipicolinate reductase, C-terminus//Peptidase family M1 GO:0055114//GO:0009085//GO:0009089 oxidation-reduction process//lysine biosynthetic process//lysine biosynthetic process via diaminopimelate GO:0008270//GO:0008237//GO:0008839 zinc ion binding//metallopeptidase activity//4-hydroxy-tetrahydrodipicolinate reductase -- -- -- -- Cluster-8309.30820 BP_3 36.95 0.59 3313 642929984 XP_008196053.1 2642 9.5e-296 PREDICTED: atrial natriuretic peptide receptor 1 [Tribolium castaneum] 642929983 XM_008197831.1 317 9.06196e-163 PREDICTED: Tribolium castaneum atrial natriuretic peptide receptor 1 (LOC664507), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18910 1596 7.6e-176 Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus GN=Npr1 PE=1 SV=1 PF00211//PF07714//PF00069//PF06330//PF07701 Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase//Protein kinase domain//Trichodiene synthase (TRI5)//Heme NO binding associated GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0016114//GO:0006144//GO:0006468//GO:0016106 cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//terpenoid biosynthetic process//purine nucleobase metabolic process//protein phosphorylation//sesquiterpenoid biosynthetic process GO:0004383//GO:0016849//GO:0004672//GO:0045482//GO:0005524 guanylate cyclase activity//phosphorus-oxygen lyase activity//protein kinase activity//trichodiene synthase activity//ATP binding -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30821 BP_3 93.00 1.95 2591 270009782 EFA06230.1 311 1.5e-25 hypothetical protein TcasGA2_TC009079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.30823 BP_3 31312.00 1280.88 1470 21218350 AAM44045.1 2268 9.8e-253 arylphorin-like hexamerin [Apriona germari] 21218349 AF509880.1 841 0 Apriona germari arylphorin-like hexamerin mRNA, complete cds -- -- -- -- Q25641 812 2.7e-85 Allergen Cr-PI OS=Periplaneta americana PE=1 SV=1 PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-8309.30824 BP_3 1289.90 32.08 2230 642913109 XP_008201396.1 803 1.1e-82 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 167 1.47183e-79 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 651 1.9e-66 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4406 CDC42 Rho GTPase-activating protein Cluster-8309.30825 BP_3 48.28 0.73 3482 642913109 XP_008201396.1 2378 4.1e-265 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 186 6.33227e-90 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 1430 1.4e-156 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.30828 BP_3 3351.42 107.10 1800 642927471 XP_008195286.1 1450 8.5e-158 PREDICTED: peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K18200 PAL peptidylamidoglycolate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K18200 Q9W1L5 1013 1.7e-108 Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 OS=Drosophila melanogaster GN=Pal2 PE=1 SV=2 PF11837//PF01436//PF01983 Domain of unknown function (DUF3357)//NHL repeat//Guanylyl transferase CofC like GO:0006012//GO:0005985//GO:0005982 galactose metabolic process//sucrose metabolic process//starch metabolic process GO:0004564//GO:0016779//GO:0005515//GO:0004575 beta-fructofuranosidase activity//nucleotidyltransferase activity//protein binding//sucrose alpha-glucosidase activity GO:0017177 glucosidase II complex KOG3567 Peptidylglycine alpha-amidating monooxygenase Cluster-8309.30829 BP_3 24.00 3.23 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3083 BP_3 2.00 1.42 355 194374393 BAG57092.1 435 8.3e-41 unnamed protein product [Homo sapiens] 223890142 NG_005980.3 355 0 Homo sapiens ribosomal protein S28 pseudogene 7 (RPS28P7) on chromosome 11 K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 Q6QAT1 276 9.4e-24 40S ribosomal protein S28 OS=Sus scrofa GN=RPS28 PE=1 SV=2 PF01200 Ribosomal protein S28e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-8309.30832 BP_3 58.32 1.02 3049 662209763 XP_008478495.1 561 1.8e-54 PREDICTED: uncharacterized protein LOC103515333 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30834 BP_3 34.35 0.39 4535 642918982 XP_008191684.1 4714 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.41308e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.30835 BP_3 132.14 1.29 5228 642918984 XP_008191685.1 4728 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X6 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.63074e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122//PF05109 E1-E2 ATPase//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058 viral life cycle GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.30836 BP_3 120.55 4.96 1464 642936428 XP_008198430.1 773 2.2e-79 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462294748 APGK01052997.1 59 1.0431e-19 Dendroctonus ponderosae Seq01053007, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 246 1.2e-19 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.30837 BP_3 120.09 3.44 1974 642923135 XP_008193624.1 380 1.1e-33 PREDICTED: nuclear receptor coactivator 2 isoform X3 [Tribolium castaneum] 642923144 XM_008195407.1 257 1.21137e-129 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X8, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30839 BP_3 166.26 1.87 4570 642925855 XP_008190573.1 1956 4.6e-216 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K06171 NCSTN nicastrin http://www.genome.jp/dbget-bin/www_bget?ko:K06171 Q9VC27 1092 2.9e-117 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF05450//PF00328 Nicastrin//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0016485//GO:0006771 hexachlorocyclohexane metabolic process//protein processing//riboflavin metabolic process GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30841 BP_3 1191.26 12.17 5008 270010959 EFA07407.1 3013 0.0e+00 protein C kinase 98E-like protein [Tribolium castaneum] 817193422 XM_012416747.1 273 3.96043e-138 PREDICTED: Orussus abietinus protein kinase C (LOC105695297), transcript variant X5, mRNA K18050 PRKCE novel protein kinase C epsilon type http://www.genome.jp/dbget-bin/www_bget?ko:K18050 Q16975 2286 1.1e-255 Calcium-independent protein kinase C OS=Aplysia californica GN=PRKC2 PE=1 SV=1 PF00130//PF00069//PF06293//PF00433//PF00628//PF07714//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//PHD-finger//Protein tyrosine kinase//C2 domain GO:0035556//GO:0016310//GO:0006468//GO:0009069 intracellular signal transduction//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0004672//GO:0016773//GO:0005515//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//protein binding//ATP binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.30843 BP_3 457.62 14.39 1825 478249999 ENN70505.1 1859 3.2e-205 hypothetical protein YQE_12681, partial [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 761 2.8e-79 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.30845 BP_3 18.00 1.77 783 642922790 XP_008193326.1 136 8.6e-06 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06357 Omega-atracotoxin GO:0009405//GO:0006952//GO:0006810 pathogenesis//defense response//transport GO:0019855 calcium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.30846 BP_3 50.11 2.63 1209 478255595 ENN75809.1 687 1.7e-69 hypothetical protein YQE_07645, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.30848 BP_3 1.85 0.65 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01842 ACT domain GO:0008152 metabolic process GO:0016597 amino acid binding -- -- -- -- Cluster-8309.3085 BP_3 66.09 1.18 3001 270002642 EEZ99089.1 3070 0.0e+00 hypothetical protein TcasGA2_TC004970, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NEN9 534 9.6e-53 PDZ domain-containing protein 8 OS=Homo sapiens GN=PDZD8 PE=1 SV=1 PF04689//PF00130//PF13180//PF01484//PF00595 DNA binding protein S1FA//Phorbol esters/diacylglycerol binding domain (C1 domain)//PDZ domain//Nematode cuticle collagen N-terminal domain//PDZ domain (Also known as DHR or GLGF) GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0042302//GO:0005515 DNA binding//structural constituent of cuticle//protein binding GO:0005634 nucleus KOG3532 Predicted protein kinase Cluster-8309.30853 BP_3 107.68 0.80 6782 642930933 XP_008196147.1 1403 9.1e-152 PREDICTED: RILP-like protein homolog [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 O76878 987 6.4e-105 RILP-like protein homolog OS=Drosophila melanogaster GN=CG11448 PE=2 SV=1 PF10473//PF01166//PF01401//PF04728//PF00038//PF00769//PF17060//PF04617//PF04111//PF07851//PF04632//PF02465//PF04508 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TSC-22/dip/bun family//Angiotensin-converting enzyme//Lipoprotein leucine-zipper//Intermediate filament protein//Ezrin/radixin/moesin family//Monopolar spindle protein 2//Hox9 activation region//Autophagy protein Apg6//TMPIT-like protein//Fusaric acid resistance protein family//Flagellar hook-associated protein 2 N-terminus//Viral A-type inclusion protein repeat GO:0006914//GO:0006810//GO:0006355//GO:0006351//GO:0016032//GO:0030474//GO:0071988//GO:0006508 autophagy//transport//regulation of transcription, DNA-templated//transcription, DNA-templated//viral process//spindle pole body duplication//protein localization to spindle pole body//proteolysis GO:0005198//GO:0008134//GO:0045502//GO:0008241//GO:0003700//GO:0008092//GO:0042803//GO:0008237 structural molecule activity//transcription factor binding//dynein binding//peptidyl-dipeptidase activity//transcription factor activity, sequence-specific DNA binding//cytoskeletal protein binding//protein homodimerization activity//metallopeptidase activity GO:0019898//GO:0016021//GO:0005882//GO:0005737//GO:0005634//GO:0030286//GO:0005886//GO:0019867//GO:0005667//GO:0009424//GO:0016020 extrinsic component of membrane//integral component of membrane//intermediate filament//cytoplasm//nucleus//dynein complex//plasma membrane//outer membrane//transcription factor complex//bacterial-type flagellum hook//membrane KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.30855 BP_3 46.82 0.70 3527 478258440 ENN78530.1 845 2.4e-87 hypothetical protein YQE_05004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q55BM1 131 6.1e-06 Probable inactive protein kinase DDB_G0270444 OS=Dictyostelium discoideum GN=DDB_G0270444 PE=1 SV=1 PF07851//PF05279//PF01442//PF05478//PF01496//PF03938//PF07464//PF08030//PF02601//PF08702 TMPIT-like protein//Aspartyl beta-hydroxylase N-terminal region//Apolipoprotein A1/A4/E domain//Prominin//V-type ATPase 116kDa subunit family//Outer membrane protein (OmpH-like)//Apolipophorin-III precursor (apoLp-III)//Ferric reductase NAD binding domain//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0055114//GO:0015992//GO:0006869//GO:0015991//GO:0042157//GO:0006308//GO:0030168 protein polymerization//signal transduction//oxidation-reduction process//proton transport//lipid transport//ATP hydrolysis coupled proton transport//lipoprotein metabolic process//DNA catabolic process//platelet activation GO:0051082//GO:0015078//GO:0005102//GO:0008855//GO:0016491//GO:0008289//GO:0030674 unfolded protein binding//hydrogen ion transmembrane transporter activity//receptor binding//exodeoxyribonuclease VII activity//oxidoreductase activity//lipid binding//protein binding, bridging GO:0016021//GO:0005577//GO:0009318//GO:0033179//GO:0005576//GO:0016020 integral component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain//extracellular region//membrane -- -- Cluster-8309.30857 BP_3 770.55 9.15 4351 607367304 EZA61451.1 490 4.3e-46 Serine/arginine-rich splicing factor, partial [Cerapachys biroi] 195401199 XM_002059166.1 102 3.93159e-43 Drosophila virilis GJ16161 (Dvir\GJ16161), mRNA K12891 SFRS2 splicing factor, arginine/serine-rich 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12891 Q06A98 418 3.9e-39 Serine/arginine-rich splicing factor 2 OS=Sus scrofa GN=SRSF2 PE=2 SV=1 PF00076//PF03106//PF00042//PF04805//PF06495//PF05001 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//WRKY DNA -binding domain//Globin//E10-like protein conserved region//Fruit fly transformer protein//RNA polymerase Rpb1 C-terminal repeat GO:0006355//GO:0055114//GO:0046660//GO:0006397//GO:0006366 regulation of transcription, DNA-templated//oxidation-reduction process//female sex differentiation//mRNA processing//transcription from RNA polymerase II promoter GO:0003676//GO:0043565//GO:0016972//GO:0003700//GO:0020037//GO:0003677//GO:0019825 nucleic acid binding//sequence-specific DNA binding//thiol oxidase activity//transcription factor activity, sequence-specific DNA binding//heme binding//DNA binding//oxygen binding GO:0005634//GO:0005665//GO:0005667 nucleus//DNA-directed RNA polymerase II, core complex//transcription factor complex KOG4207 Predicted splicing factor, SR protein superfamily Cluster-8309.30858 BP_3 152.11 1.52 5121 546671618 ERL83852.1 1520 1.9e-165 hypothetical protein D910_01119, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30859 BP_3 145.21 2.99 2631 642918375 XP_008200060.1 2382 1.1e-265 PREDICTED: ankyrin-2-like isoform X5 [Tribolium castaneum] 836709203 XM_012933675.1 92 8.57033e-38 PREDICTED: Sorex araneus ankyrin 2, neuronal (ANK2), mRNA K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 G5E8K5 1191 5.5e-129 Ankyrin-3 OS=Mus musculus GN=Ank3 PE=1 SV=1 PF00531//PF04281 Death domain//Mitochondrial import receptor subunit Tom22 GO:0006886//GO:0007165 intracellular protein transport//signal transduction GO:0005515 protein binding GO:0005741 mitochondrial outer membrane KOG4177 Ankyrin Cluster-8309.30861 BP_3 1383.91 6.63 10346 642928433 XP_008193783.1 6548 0.0e+00 PREDICTED: proteasome activator complex subunit 4 [Tribolium castaneum]>gi|270010813|gb|EFA07261.1| hypothetical protein TcasGA2_TC013292 [Tribolium castaneum] -- -- -- -- -- K06699 PSME4 proteasome activator subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06699 Q14997 3168 0.0e+00 Proteasome activator complex subunit 4 OS=Homo sapiens GN=PSME4 PE=1 SV=2 PF02985//PF01193//PF06743//PF01000 HEAT repeat//RNA polymerase Rpb3/Rpb11 dimerisation domain//FAST kinase-like protein, subdomain 1//RNA polymerase Rpb3/RpoA insert domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0004672//GO:0003899//GO:0046983//GO:0005515 protein kinase activity//DNA-directed RNA polymerase activity//protein dimerization activity//protein binding GO:0005730 nucleolus KOG1521 RNA polymerase I and III, subunit RPA40/RPC40 Cluster-8309.30862 BP_3 2.15 2.25 329 332372889 AEE61586.1 201 1.0e-13 unknown [Dendroctonus ponderosae]>gi|478253022|gb|ENN73402.1| hypothetical protein YQE_09964, partial [Dendroctonus ponderosae] -- -- -- -- -- K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q99437 176 3.4e-12 V-type proton ATPase 21 kDa proteolipid subunit OS=Homo sapiens GN=ATP6V0B PE=2 SV=1 PF00137//PF00771 ATP synthase subunit C//FHIPEP family GO:0015991//GO:0009306//GO:0015992 ATP hydrolysis coupled proton transport//protein secretion//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0016020//GO:0033177 membrane//proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.30863 BP_3 11.38 0.57 1256 332372889 AEE61586.1 526 8.3e-51 unknown [Dendroctonus ponderosae]>gi|478253022|gb|ENN73402.1| hypothetical protein YQE_09964, partial [Dendroctonus ponderosae] -- -- -- -- -- K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q91V37 427 1.0e-40 V-type proton ATPase 21 kDa proteolipid subunit OS=Mus musculus GN=Atp6v0b PE=1 SV=1 PF00137//PF16954//PF00771 ATP synthase subunit C//Haem-transporter, endosomal/lysosomal, haem-responsive gene//FHIPEP family GO:0015992//GO:0015991//GO:0015886//GO:0009306 proton transport//ATP hydrolysis coupled proton transport//heme transport//protein secretion GO:0015078//GO:0015232 hydrogen ion transmembrane transporter activity//heme transporter activity GO:0016020//GO:0033177 membrane//proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.30864 BP_3 492.76 5.30 4772 478256425 ENN76612.1 690 3.0e-69 hypothetical protein YQE_06869, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1LWH4 352 1.9e-31 Fanconi-associated nuclease 1 OS=Danio rerio GN=fan1 PE=2 SV=2 PF00829//PF08774 Ribosomal prokaryotic L21 protein//VRR-NUC domain -- -- GO:0016788 hydrolase activity, acting on ester bonds GO:0005840 ribosome KOG2143 Uncharacterized conserved protein Cluster-8309.30865 BP_3 252.22 47.42 548 642920083 XP_008192197.1 437 7.5e-41 PREDICTED: glycogen synthase kinase-3 beta isoform X2 [Tribolium castaneum] 645029971 XM_008210300.1 55 6.28028e-18 PREDICTED: Nasonia vitripennis glycogen synthase kinase-3 beta (LOC100117808), transcript variant X7, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P49841 319 1.5e-28 Glycogen synthase kinase-3 beta OS=Homo sapiens GN=GSK3B PE=1 SV=2 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0658 Glycogen synthase kinase-3 Cluster-8309.30867 BP_3 1255.70 14.57 4445 91081429 XP_973458.1 2939 0.0e+00 PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|642920877|ref|XP_008192597.1| PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|270006127|gb|EFA02575.1| hypothetical protein TcasGA2_TC008293 [Tribolium castaneum] 749790449 XM_011150162.1 133 2.35029e-60 PREDICTED: Harpegnathos saltator ATP-binding cassette sub-family G member 4 (LOC105188614), mRNA K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 Q9H172 1631 8.9e-180 ATP-binding cassette sub-family G member 4 OS=Homo sapiens GN=ABCG4 PE=1 SV=2 PF03193//PF00005//PF13304//PF01926//PF01061 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter GO:0006200 obsolete ATP catabolic process GO:0016887//GO:0005525//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATP binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.30868 BP_3 456.00 8.62 2841 91095245 XP_970564.1 805 8.3e-83 PREDICTED: E3 ubiquitin-protein ligase RING1 [Tribolium castaneum]>gi|270017230|gb|EFA13676.1| hypothetical protein TcasGA2_TC001392 [Tribolium castaneum] 560952652 XM_006198790.1 113 1.9618e-49 PREDICTED: Vicugna pacos ring finger protein 2 (RNF2), mRNA K10695 RNF1_2 E3 ubiquitin-protein ligase RNF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10695 Q66J69 674 5.3e-69 E3 ubiquitin-protein ligase RING2-A OS=Xenopus laevis GN=rnf2-a PE=2 SV=1 PF02891//PF01396//PF06624//PF13639//PF17123//PF12678//PF14634//PF14372//PF17121//PF00097//PF11789 MIZ/SP-RING zinc finger//Topoisomerase DNA binding C4 zinc finger//Ribosome associated membrane protein RAMP4//Ring finger domain//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Domain of unknown function (DUF4413)//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit GO:0006265 DNA topological change GO:0008270//GO:0046872//GO:0003677//GO:0005515//GO:0003916 zinc ion binding//metal ion binding//DNA binding//protein binding//DNA topoisomerase activity GO:0005694//GO:0005783 chromosome//endoplasmic reticulum KOG0311 Predicted E3 ubiquitin ligase Cluster-8309.30869 BP_3 684.76 7.64 4612 255918127 NP_001157610.1 1687 7.2e-185 tramtrack [Tribolium castaneum]>gi|642921896|ref|XP_008192935.1| PREDICTED: tramtrack isoform X1 [Tribolium castaneum] 751794272 XR_852685.1 49 1.20951e-13 PREDICTED: Bactrocera dorsalis polyhomeotic-proximal chromatin protein-like (LOC105228656), transcript variant X5, misc_RNA K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 578 1.2e-57 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF13912//PF02178//PF13465//PF00096 BTB/POZ domain//C2H2-type zinc finger//AT hook motif//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0005515//GO:0046872 DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.30870 BP_3 456.26 2.91 7849 270000975 EEZ97422.1 5016 0.0e+00 hypothetical protein TcasGA2_TC011252 [Tribolium castaneum] 662206951 XM_008478733.1 135 3.21821e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 4249 0.0e+00 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF03079//PF01648//PF00008//PF01106 ARD/ARD' family//4'-phosphopantetheinyl transferase superfamily//EGF-like domain//NifU-like domain GO:0015940//GO:0016226//GO:0055114 pantothenate biosynthetic process//iron-sulfur cluster assembly//oxidation-reduction process GO:0008897//GO:0005515//GO:0010309//GO:0005506//GO:0000287//GO:0051536 holo-[acyl-carrier-protein] synthase activity//protein binding//acireductone dioxygenase [iron(II)-requiring] activity//iron ion binding//magnesium ion binding//iron-sulfur cluster binding -- -- -- -- Cluster-8309.30871 BP_3 3793.44 48.99 4024 642936745 XP_008198563.1 3125 0.0e+00 PREDICTED: neurexin-4 isoform X2 [Tribolium castaneum] 662206951 XM_008478733.1 135 1.6434e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 2433 8.1e-273 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF00008//PF00190//PF01106//PF03079 EGF-like domain//Cupin//NifU-like domain//ARD/ARD' family GO:0016226//GO:0055114 iron-sulfur cluster assembly//oxidation-reduction process GO:0051536//GO:0045735//GO:0010309//GO:0005506//GO:0005515 iron-sulfur cluster binding//nutrient reservoir activity//acireductone dioxygenase [iron(II)-requiring] activity//iron ion binding//protein binding -- -- -- -- Cluster-8309.30872 BP_3 139.56 6.97 1257 642933598 XP_008197488.1 929 1.5e-97 PREDICTED: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4IMF6 780 1.2e-81 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Drosophila sechellia GN=GM13534 PE=3 SV=1 PF01106 NifU-like domain GO:0016226 iron-sulfur cluster assembly GO:0051536//GO:0005506 iron-sulfur cluster binding//iron ion binding -- -- KOG2358 NifU-like domain-containing proteins Cluster-8309.30873 BP_3 943.99 487.03 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15178 Mitochondrial import receptor subunit TOM5 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.30875 BP_3 91.25 0.95 4943 478260665 ENN80362.1 1376 8.9e-149 hypothetical protein YQE_03221, partial [Dendroctonus ponderosae]>gi|478269621|gb|ENN83368.1| hypothetical protein YQE_00276, partial [Dendroctonus ponderosae]>gi|546683697|gb|ERL93475.1| hypothetical protein D910_10766 [Dendroctonus ponderosae] -- -- -- -- -- K08592 SENP1 sentrin-specific protease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08592 Q9VXP4 724 1.5e-74 Platelet-activating factor acetylhydrolase IB subunit beta homolog OS=Drosophila melanogaster GN=Paf-AHalpha PE=1 SV=1 PF00770//PF00657//PF02902 Adenovirus endoprotease//GDSL-like Lipase/Acylhydrolase//Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0016788//GO:0008234//GO:0004197 hydrolase activity, acting on ester bonds//cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG0778 Protease, Ulp1 family Cluster-8309.30876 BP_3 1985.95 181.20 820 546681029 ERL91194.1 353 6.2e-31 hypothetical protein D910_08533 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P26352 128 3.1e-06 Thymosin beta-12 OS=Oncorhynchus mykiss PE=1 SV=2 PF01290 Thymosin beta-4 family GO:0007015 actin filament organization GO:0003785 actin monomer binding -- -- KOG4794 Thymosin beta Cluster-8309.30880 BP_3 77.03 2.56 1741 189234116 XP_968417.2 1151 3.9e-123 PREDICTED: uridine phosphorylase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 P52624 626 1.2e-63 Uridine phosphorylase 1 OS=Mus musculus GN=Upp1 PE=1 SV=2 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3728 Uridine phosphorylase Cluster-8309.30883 BP_3 13.68 0.42 1852 270002846 EEZ99293.1 1759 1.3e-193 sevenless [Tribolium castaneum] 695158202 XM_009508869.1 44 2.89135e-11 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P13368 634 1.5e-64 Protein sevenless OS=Drosophila melanogaster GN=sev PE=1 SV=2 PF07714//PF00069//PF00041//PF16656 Protein tyrosine kinase//Protein kinase domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006468//GO:0006771 hexachlorocyclohexane metabolic process//protein phosphorylation//riboflavin metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0046872//GO:0003993 protein binding//ATP binding//protein kinase activity//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-8309.30884 BP_3 522.11 4.65 5700 642936624 XP_008198511.1 2726 3.0e-305 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.08822e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.8e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF01166//PF02346 TSC-22/dip/bun family//Chordopoxvirus multifunctional envelope protein A27 GO:0006355//GO:0019064 regulation of transcription, DNA-templated//fusion of virus membrane with host plasma membrane GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.30886 BP_3 26.96 0.85 1814 642927984 XP_008195472.1 735 7.0e-75 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30887 BP_3 3.64 0.33 820 642930121 XP_008196261.1 257 8.4e-20 PREDICTED: acylphosphatase-1-like [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 P56544 204 4.8e-15 Acylphosphatase-1 OS=Drosophila melanogaster GN=Acyp PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30888 BP_3 2119.01 24.30 4494 91088575 XP_973165.1 4337 0.0e+00 PREDICTED: ubiquitin conjugation factor E4 B [Tribolium castaneum]>gi|270011701|gb|EFA08149.1| hypothetical protein TcasGA2_TC005767 [Tribolium castaneum] -- -- -- -- -- K10597 UBE4B, UFD2 ubiquitin conjugation factor E4 B http://www.genome.jp/dbget-bin/www_bget?ko:K10597 Q9ES00 2276 1.5e-254 Ubiquitin conjugation factor E4 B OS=Mus musculus GN=Ube4b PE=1 SV=3 PF04564//PF10408 U-box domain//Ubiquitin elongating factor core GO:0006511//GO:0016567 ubiquitin-dependent protein catabolic process//protein ubiquitination GO:0004842//GO:0034450 ubiquitin-protein transferase activity//ubiquitin-ubiquitin ligase activity GO:0000151 ubiquitin ligase complex KOG2042 Ubiquitin fusion degradation protein-2 Cluster-8309.30890 BP_3 618.31 5.68 5537 642937775 XP_008198940.1 5800 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X2 [Tribolium castaneum] 665815760 XM_008558331.1 166 1.32625e-78 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 3294 0.0e+00 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0206 P-type ATPase Cluster-8309.30891 BP_3 1.00 0.39 413 157129974 XP_001655497.1 154 3.7e-08 AAEL000375-PA [Aedes aegypti]>gi|108884380|gb|EAT48605.1| AAEL000375-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- P0DM55 124 4.6e-06 Venom peptide SjAPI OS=Scorpiops jendeki PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30893 BP_3 16.27 0.46 2004 91095219 XP_969883.1 641 6.1e-64 PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940081|ref|XP_008192927.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940083|ref|XP_008192931.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|270016019|gb|EFA12467.1| hypothetical protein TcasGA2_TC010611 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q765P3 488 1.4e-47 Peptidoglycan-recognition protein 2 OS=Holotrichia diomphalia GN=PGRP-2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30894 BP_3 181.27 4.54 2217 91086813 XP_973672.1 221 3.4e-15 PREDICTED: neutral and basic amino acid transport protein rBAT [Tribolium castaneum]>gi|270010450|gb|EFA06898.1| hypothetical protein TcasGA2_TC009845 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30895 BP_3 608.48 6.01 5174 642928927 XP_008195620.1 2199 3.5e-244 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 282 4.0638e-143 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 559 2.1e-55 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30897 BP_3 797.07 9.82 4202 642932106 XP_008196856.1 1545 1.9e-168 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X5 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.38468e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 5.4e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF01213//PF07525//PF00622 Adenylate cyclase associated (CAP) N terminal//SOCS box//SPRY domain GO:0035556//GO:0007010 intracellular signal transduction//cytoskeleton organization GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.30898 BP_3 259.65 0.84 15222 642934437 XP_008197662.1 5595 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X1 [Tribolium castaneum]>gi|270013709|gb|EFA10157.1| hypothetical protein TcasGA2_TC012345 [Tribolium castaneum] 642934440 XM_008199442.1 135 6.25319e-61 PREDICTED: Tribolium castaneum nucleosome-remodeling factor subunit NURF301 (LOC100141790), transcript variant X3, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1598 2.0e-175 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF12125//PF02178//PF00155//PF13639//PF16866//PF00628//PF00202//PF00439 D domain of beta-TrCP//AT hook motif//Aminotransferase class I and II//Ring finger domain//PHD-finger//PHD-finger//Aminotransferase class-III//Bromodomain GO:0009058 biosynthetic process GO:0005488//GO:0008270//GO:0008483//GO:0005515//GO:0046983//GO:0030170//GO:0003677 binding//zinc ion binding//transaminase activity//protein binding//protein dimerization activity//pyridoxal phosphate binding//DNA binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.30899 BP_3 4.22 0.49 708 270016290 EFA12736.1 180 6.2e-11 hypothetical protein TcasGA2_TC002373 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30900 BP_3 794.95 9.72 4235 158299912 XP_319921.4 2480 7.4e-277 AGAP009160-PA [Anopheles gambiae str. PEST]>gi|157013746|gb|EAA14733.4| AGAP009160-PA [Anopheles gambiae str. PEST] 701339117 XM_009982980.1 98 6.40207e-41 PREDICTED: Tauraco erythrolophus arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like (LOC104376406), partial mRNA K12491 AGAP1_3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12491 Q9NGC3 1460 5.7e-160 Centaurin-gamma-1A OS=Drosophila melanogaster GN=CenG1A PE=2 SV=2 PF00071//PF01412//PF13606//PF08477//PF00023 Ras family//Putative GTPase activating protein for Arf//Ankyrin repeat//Ras of Complex, Roc, domain of DAPkinase//Ankyrin repeat GO:0007264//GO:0050794 small GTPase mediated signal transduction//regulation of cellular process GO:0005515//GO:0005488//GO:0005525//GO:0005096 protein binding//binding//GTP binding//GTPase activator activity -- -- KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains) Cluster-8309.30901 BP_3 62.00 10.70 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30902 BP_3 2.00 1.96 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30903 BP_3 45.81 0.79 3072 642937652 XP_966876.3 559 3.0e-54 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N4W9 383 3.2e-35 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF00096//PF13465//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.30905 BP_3 38.87 0.55 3707 642937018 XP_008198655.1 2034 3.4e-225 PREDICTED: neutral ceramidase-like [Tribolium castaneum] -- -- -- -- -- K12349 ASAH2 neutral ceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K12349 Q29C43 1486 4.8e-163 Neutral ceramidase OS=Drosophila pseudoobscura pseudoobscura GN=CDase PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2232 Ceramidases Cluster-8309.30907 BP_3 345.00 7.96 2381 478256547 ENN76731.1 2406 1.6e-268 hypothetical protein YQE_06796, partial [Dendroctonus ponderosae] -- -- -- -- -- K11438 PRMT7 protein arginine N-methyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11438 Q16NS8 1542 1.0e-169 Protein arginine N-methyltransferase 7 OS=Aedes aegypti GN=Art7 PE=3 SV=1 PF08241//PF02390//PF00965//PF05175//PF03602 Methyltransferase domain//Putative methyltransferase//Tissue inhibitor of metalloproteinase//Methyltransferase small domain//Conserved hypothetical protein 95 GO:0008152//GO:0031167//GO:0009451//GO:0008033//GO:0006400 metabolic process//rRNA methylation//RNA modification//tRNA processing//tRNA modification GO:0008191//GO:0008176//GO:0008168 metalloendopeptidase inhibitor activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.30908 BP_3 13.88 0.52 1571 478260112 ENN79897.1 1268 9.5e-137 hypothetical protein YQE_03716, partial [Dendroctonus ponderosae]>gi|546679495|gb|ERL89954.1| hypothetical protein D910_07313 [Dendroctonus ponderosae] -- -- -- -- -- K00415 QCR2, UQCRC2 ubiquinol-cytochrome c reductase core subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K00415 Q9DB77 586 4.7e-59 Cytochrome b-c1 complex subunit 2, mitochondrial OS=Mus musculus GN=Uqcrc2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2583 Ubiquinol cytochrome c reductase, subunit QCR2 Cluster-8309.30909 BP_3 14.03 0.46 1771 478260112 ENN79897.1 628 1.7e-62 hypothetical protein YQE_03716, partial [Dendroctonus ponderosae]>gi|546679495|gb|ERL89954.1| hypothetical protein D910_07313 [Dendroctonus ponderosae] -- -- -- -- -- K00415 QCR2, UQCRC2 ubiquinol-cytochrome c reductase core subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K00415 Q9DB77 299 1.0e-25 Cytochrome b-c1 complex subunit 2, mitochondrial OS=Mus musculus GN=Uqcrc2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2583 Ubiquinol cytochrome c reductase, subunit QCR2 Cluster-8309.30911 BP_3 3.00 1.80 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30912 BP_3 85.67 0.75 5833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.30913 BP_3 19.29 1.06 1169 270016897 EFA13343.1 199 6.4e-13 hypothetical protein TcasGA2_TC005298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- -- -- Cluster-8309.30916 BP_3 623.83 4.44 7057 642935775 XP_008198168.1 1750 5.5e-192 PREDICTED: integrin alpha-PS3-like [Tribolium castaneum] -- -- -- -- -- K17595 SPATA2 spermatogenesis-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17595 O44386 660 5.5e-67 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 PF00641//PF08516 Zn-finger in Ran binding protein and others//ADAM cysteine-rich GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.30917 BP_3 149.00 31.44 520 642919151 XP_008191758.1 268 2.8e-21 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95209 122 9.9e-06 Sortilin-related receptor OS=Oryctolagus cuniculus GN=SORL1 PE=2 SV=1 PF00866 Ring hydroxylating beta subunit GO:0055114//GO:0006725 oxidation-reduction process//cellular aromatic compound metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.30918 BP_3 1390.74 8.62 8070 768420852 XP_011551210.1 1115 2.7e-118 PREDICTED: E3 ubiquitin-protein ligase SIAH1-like [Plutella xylostella] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q920M9 1094 3.0e-117 E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 PE=1 SV=2 PF00198//PF05191//PF00097//PF03145//PF02817 2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Adenylate kinase, active site lid//Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//e3 binding domain GO:0006511//GO:0008152//GO:0007275//GO:0006144//GO:0046034 ubiquitin-dependent protein catabolic process//metabolic process//multicellular organismal development//purine nucleobase metabolic process//ATP metabolic process GO:0004017//GO:0046872//GO:0016746 adenylate kinase activity//metal ion binding//transferase activity, transferring acyl groups GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.30919 BP_3 131.60 1.84 3747 642932076 XP_008196848.1 834 4.8e-86 PREDICTED: pre-mRNA-splicing regulator female-lethal(2)D [Tribolium castaneum]>gi|270011667|gb|EFA08115.1| hypothetical protein TcasGA2_TC005719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28XY0 591 3.0e-59 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila pseudoobscura pseudoobscura GN=fl(2)d PE=3 SV=2 PF04799//PF09177//PF04977//PF06156//PF05791//PF17098//PF06005//PF11744//PF01496 fzo-like conserved region//Syntaxin 6, N-terminal//Septum formation initiator//Protein of unknown function (DUF972)//Bacillus haemolytic enterotoxin (HBL)//Pre-mRNA-splicing regulator WTAP//Protein of unknown function (DUF904)//Aluminium activated malate transporter//V-type ATPase 116kDa subunit family GO:0048024//GO:0008053//GO:0043093//GO:0000917//GO:0048193//GO:0015991//GO:0015743//GO:0006260//GO:0015992//GO:0007049//GO:0009405 regulation of mRNA splicing, via spliceosome//mitochondrial fusion//FtsZ-dependent cytokinesis//barrier septum assembly//Golgi vesicle transport//ATP hydrolysis coupled proton transport//malate transport//DNA replication//proton transport//cell cycle//pathogenesis GO:0015078//GO:0003924 hydrogen ion transmembrane transporter activity//GTPase activity GO:0016020//GO:0005741//GO:0033179//GO:0005634//GO:0005737//GO:0016021 membrane//mitochondrial outer membrane//proton-transporting V-type ATPase, V0 domain//nucleus//cytoplasm//integral component of membrane KOG2991 Splicing regulator Cluster-8309.30921 BP_3 238.60 3.09 4018 642932892 XP_008197175.1 730 5.9e-74 PREDICTED: uncharacterized protein LOC103314074 [Tribolium castaneum]>gi|270011476|gb|EFA07924.1| hypothetical protein TcasGA2_TC005502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30922 BP_3 57.00 59.59 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30923 BP_3 13.99 0.42 1880 859132814 AKO63320.1 441 8.9e-41 mevalonate kinase [Leptinotarsa decemlineata] -- -- -- -- -- K00869 E2.7.1.36, MVK, mvaK1 mevalonate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00869 P46086 207 5.0e-15 Mevalonate kinase OS=Arabidopsis thaliana GN=At5g27450 PE=2 SV=1 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- KOG1511 Mevalonate kinase MVK/ERG12 Cluster-8309.30926 BP_3 5.59 0.58 759 642913478 XP_008201029.1 472 9.1e-45 PREDICTED: dolichol kinase [Tribolium castaneum] -- -- -- -- -- K00902 E2.7.1.108 dolichol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00902 Q8R2Y3 281 5.3e-24 Dolichol kinase OS=Mus musculus GN=Dolk PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2468 Dolichol kinase Cluster-8309.30929 BP_3 368.97 18.07 1276 91081235 XP_975638.1 1065 2.7e-113 PREDICTED: ubiquitin thioesterase otubain-like [Tribolium castaneum]>gi|270006065|gb|EFA02513.1| hypothetical protein TcasGA2_TC008217 [Tribolium castaneum] -- -- -- -- -- K09602 OTUB1 ubiquitin thioesterase protein OTUB1 http://www.genome.jp/dbget-bin/www_bget?ko:K09602 Q9VL00 739 6.9e-77 Ubiquitin thioesterase otubain-like OS=Drosophila melanogaster GN=CG4968 PE=2 SV=1 -- -- GO:0019538 protein metabolic process GO:0008242 omega peptidase activity -- -- KOG3991 Uncharacterized conserved protein Cluster-8309.30930 BP_3 22.48 0.54 2308 270016209 EFA12655.1 234 1.1e-16 aminopeptidase-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VZH2 128 8.9e-06 Aminopeptidase M1 OS=Arabidopsis thaliana GN=APM1 PE=1 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.30932 BP_3 68.00 8.97 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30933 BP_3 27.08 0.54 2703 642914145 XP_008201564.1 333 4.3e-28 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30935 BP_3 35.34 0.61 3072 546684665 ERL94282.1 285 1.8e-22 hypothetical protein D910_11563 [Dendroctonus ponderosae] -- -- -- -- -- K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 A4QNI8 198 9.0e-14 ELAV-like protein 4 OS=Xenopus tropicalis GN=elavl4 PE=2 SV=1 PF00076//PF01534 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Frizzled/Smoothened family membrane region GO:0007166 cell surface receptor signaling pathway GO:0003676 nucleic acid binding GO:0016020 membrane KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.30937 BP_3 1019.68 61.80 1087 91080235 XP_972829.1 191 5.0e-12 PREDICTED: caprin homolog [Tribolium castaneum]>gi|270005626|gb|EFA02074.1| hypothetical protein TcasGA2_TC007709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0006865//GO:0003333 amino acid transport//amino acid transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.30938 BP_3 5184.00 62.40 4296 237681147 NP_001153720.1 2487 1.2e-277 semaphorin-1a [Tribolium castaneum]>gi|270015157|gb|EFA11605.1| semaphorin-1a-like protein [Tribolium castaneum] -- -- -- -- -- K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q26972 2358 4.3e-264 Semaphorin-1A OS=Tribolium confusum GN=SEMA-1A PE=2 SV=1 PF01403//PF01437 Sema domain//Plexin repeat GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0005515//GO:0004872 protein binding//receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3611 Semaphorins Cluster-8309.30939 BP_3 1063.97 34.67 1771 642936923 XP_970894.2 1001 9.7e-106 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 264 1.2e-21 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF03776//PF13606//PF00023//PF09494 Septum formation topological specificity factor MinE//Ankyrin repeat//Ankyrin repeat//Slx4 endonuclease GO:0051301//GO:0006260//GO:0032955//GO:0006308//GO:0006281 cell division//DNA replication//regulation of barrier septum assembly//DNA catabolic process//DNA repair GO:0005515//GO:0017108 protein binding//5'-flap endonuclease activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus -- -- Cluster-8309.30941 BP_3 862.67 8.67 5086 91089275 XP_970398.1 2665 3.1e-298 PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase 9 isoform X1 [Tribolium castaneum] 642933027 XM_965305.2 493 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 2186 4.5e-244 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.30942 BP_3 1756.93 46.04 2131 189237581 XP_974946.2 1234 1.1e-132 PREDICTED: glypican-6 [Tribolium castaneum] -- -- -- -- -- K08110 GPC4 glypican 4 (K-glypican) http://www.genome.jp/dbget-bin/www_bget?ko:K08110 Q5RE54 675 3.0e-69 Glypican-6 OS=Pongo abelii GN=GPC6 PE=2 SV=1 PF12906//PF01153//PF02404 RING-variant domain//Glypican//Stem cell factor GO:0007165//GO:0007155 signal transduction//cell adhesion GO:0005173//GO:0008270//GO:0043395 stem cell factor receptor binding//zinc ion binding//heparan sulfate proteoglycan binding GO:0016020//GO:0005578 membrane//proteinaceous extracellular matrix KOG3821 Heparin sulfate cell surface proteoglycan Cluster-8309.30944 BP_3 131.15 6.58 1252 189235871 XP_001811450.1 819 8.7e-85 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30946 BP_3 3.00 7.56 287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30947 BP_3 431.31 3.37 6460 270014138 EFA10586.1 5229 0.0e+00 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936567 XM_008200267.1 595 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X1, mRNA -- -- -- -- Q07553 1915 1.5e-212 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00069//PF00211//PF07714//PF00558//PF07701 Protein kinase domain//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase//Vpu protein//Heme NO binding associated GO:0006812//GO:0032801//GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0019076//GO:0006144//GO:0006468 cation transport//receptor catabolic process//cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//viral release from host cell//purine nucleobase metabolic process//protein phosphorylation GO:0004383//GO:0016849//GO:0004672//GO:0005524//GO:0005261 guanylate cyclase activity//phosphorus-oxygen lyase activity//protein kinase activity//ATP binding//cation channel activity GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30948 BP_3 495.04 2.68 9198 270014138 EFA10586.1 4698 0.0e+00 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936567 XM_008200267.1 579 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X1, mRNA -- -- -- -- Q07553 1915 2.2e-212 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF15427//PF01073//PF07701//PF00558//PF07714//PF00211//PF02866//PF00069//PF00056 S100P-binding protein//3-beta hydroxysteroid dehydrogenase/isomerase family//Heme NO binding associated//Vpu protein//Protein tyrosine kinase//Adenylate and Guanylate cyclase catalytic domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Protein kinase domain//lactate/malate dehydrogenase, NAD binding domain GO:0006182//GO:0008210//GO:0006144//GO:0019076//GO:0032801//GO:0046039//GO:0006468//GO:0006812//GO:0008207//GO:0035556//GO:0006694//GO:0055114//GO:0008209//GO:0009190 cGMP biosynthetic process//estrogen metabolic process//purine nucleobase metabolic process//viral release from host cell//receptor catabolic process//GTP metabolic process//protein phosphorylation//cation transport//C21-steroid hormone metabolic process//intracellular signal transduction//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//cyclic nucleotide biosynthetic process GO:0016491//GO:0004672//GO:0016849//GO:0003854//GO:0005524//GO:0005261//GO:0016616//GO:0004383//GO:0048306 oxidoreductase activity//protein kinase activity//phosphorus-oxygen lyase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//ATP binding//cation channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//guanylate cyclase activity//calcium-dependent protein binding GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30949 BP_3 265.93 2.51 5398 270014138 EFA10586.1 2956 0.0e+00 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936569 XM_008200268.1 293 3.25536e-149 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X2, mRNA -- -- -- -- Q07553 1001 1.2e-106 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00558//PF07701//PF00211//PF07714//PF00069 Vpu protein//Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase//Protein kinase domain GO:0006182//GO:0046039//GO:0019076//GO:0006144//GO:0006468//GO:0006812//GO:0035556//GO:0032801//GO:0009190 cGMP biosynthetic process//GTP metabolic process//viral release from host cell//purine nucleobase metabolic process//protein phosphorylation//cation transport//intracellular signal transduction//receptor catabolic process//cyclic nucleotide biosynthetic process GO:0005524//GO:0005261//GO:0004383//GO:0004672//GO:0016849 ATP binding//cation channel activity//guanylate cyclase activity//protein kinase activity//phosphorus-oxygen lyase activity GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30953 BP_3 3.51 0.35 776 91077456 XP_967801.1 471 1.2e-44 PREDICTED: sine oculis-binding protein homolog [Tribolium castaneum]>gi|270002754|gb|EEZ99201.1| sine oculis-binding protein [Tribolium castaneum] 768434667 XM_011560449.1 63 3.23776e-22 PREDICTED: Plutella xylostella sine oculis-binding protein homolog (LOC105389350), partial mRNA -- -- -- -- Q0P5V2 130 1.7e-06 Sine oculis-binding protein homolog OS=Mus musculus GN=Sobp PE=2 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.30954 BP_3 626.79 12.67 2676 662209763 XP_008478495.1 561 1.5e-54 PREDICTED: uncharacterized protein LOC103515333 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30959 BP_3 5.00 0.99 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30960 BP_3 38.61 0.85 2490 332375851 AEE63066.1 1156 1.5e-123 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 P17439 819 7.2e-86 Glucosylceramidase OS=Mus musculus GN=Gba PE=1 SV=1 PF02055//PF02806 O-Glycosyl hydrolase family 30//Alpha amylase, C-terminal all-beta domain GO:0005975//GO:0006687//GO:0006807//GO:0006665 carbohydrate metabolic process//glycosphingolipid metabolic process//nitrogen compound metabolic process//sphingolipid metabolic process GO:0004348//GO:0043169//GO:0003824 glucosylceramidase activity//cation binding//catalytic activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.30962 BP_3 2667.42 13.84 9580 546684972 ERL94546.1 4054 0.0e+00 hypothetical protein D910_11823 [Dendroctonus ponderosae] 768442001 XM_011564452.1 512 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q9Z1N3 1894 6.1e-210 Unconventional myosin-IXa OS=Rattus norvegicus GN=Myo9a PE=1 SV=1 PF00437//PF00130//PF15177//PF00612//PF12678//PF00628//PF07649//PF00063//PF00788//PF02954//PF09280//PF00620 Type II/IV secretion system protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Interleukin-28A//IQ calmodulin-binding motif//RING-H2 zinc finger//PHD-finger//C1-like domain//Myosin head (motor domain)//Ras association (RalGDS/AF-6) domain//Bacterial regulatory protein, Fis family//XPC-binding domain//RhoGAP domain GO:0006281//GO:0006810//GO:0007165//GO:0055114//GO:0035556//GO:0051607//GO:0050778//GO:0007259//GO:0043161//GO:0006289 DNA repair//transport//signal transduction//oxidation-reduction process//intracellular signal transduction//defense response to virus//positive regulation of immune response//JAK-STAT cascade//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair GO:0005524//GO:0047134//GO:0005125//GO:0043565//GO:0008270//GO:0005515//GO:0003684//GO:0003774 ATP binding//protein-disulfide reductase activity//cytokine activity//sequence-specific DNA binding//zinc ion binding//protein binding//damaged DNA binding//motor activity GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.30964 BP_3 8.00 1.61 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30965 BP_3 29.62 1.81 1079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30969 BP_3 3.00 46.59 232 1168338 P45521.1 202 5.7e-14 RecName: Full=Actin, partial [Procambarus clarkii] 724908519 XM_010380427.1 103 5.073e-45 PREDICTED: Rhinopithecus roxellana actin, muscle-like (LOC104675775), transcript variant X2, mRNA K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 P45521 202 2.3e-15 Actin (Fragment) OS=Procambarus clarkii PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.30970 BP_3 48.40 0.51 4908 91086115 XP_968072.1 1323 1.2e-142 PREDICTED: sister chromatid cohesion protein DCC1 [Tribolium castaneum] -- -- -- -- -- K11271 DSCC1, DCC1 sister chromatid cohesion protein DCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K11271 Q6GMB0 633 5.2e-64 Sister chromatid cohesion protein DCC1 OS=Xenopus laevis GN=dscc1 PE=2 SV=1 PF00018//PF14604//PF04088//PF04421 SH3 domain//Variant SH3 domain//Peroxin 13, N-terminal region//Mss4 protein GO:0007264//GO:0016560//GO:0043087 small GTPase mediated signal transduction//protein import into peroxisome matrix, docking//regulation of GTPase activity GO:0005515//GO:0005085 protein binding//guanyl-nucleotide exchange factor activity GO:0005777//GO:0016021 peroxisome//integral component of membrane KOG3875 Peroxisomal biogenesis protein peroxin Cluster-8309.30973 BP_3 228.60 5.80 2191 546684096 ERL93815.1 355 9.7e-31 hypothetical protein D910_11101 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P49096 197 8.4e-14 Cytochrome b5 OS=Musca domestica GN=Cyt-b5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0537 Cytochrome b5 Cluster-8309.30975 BP_3 93.74 4.19 1369 642913555 XP_008201060.1 1209 5.7e-130 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X1 [Tribolium castaneum] 642913554 XM_008202838.1 344 3.61261e-178 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X1, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 P82252 649 2.0e-66 b(0,+)-type amino acid transporter 1 OS=Rattus norvegicus GN=Slc7a9 PE=1 SV=1 PF03222//PF00324//PF04544//PF13520 Tryptophan/tyrosine permease family//Amino acid permease//Herpesvirus egress protein UL20//Amino acid permease GO:0003333//GO:0055085//GO:0006865//GO:0006810//GO:0019058 amino acid transmembrane transport//transmembrane transport//amino acid transport//transport//viral life cycle GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.30976 BP_3 51.84 2.96 1135 642936307 XP_008198389.1 509 7.0e-49 PREDICTED: protein FAM107B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI00 145 4.6e-08 Protein FAM107B OS=Bos taurus GN=FAM107B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30977 BP_3 7026.27 78.12 4627 189241000 XP_968712.2 3471 0.0e+00 PREDICTED: protein Skeletor, isoforms B/C isoform X1 [Tribolium castaneum]>gi|557470278|gb|AHA05989.1| knickkopf 3 [Tribolium castaneum] 642935031 XM_008201691.1 245 1.34348e-122 PREDICTED: Tribolium castaneum knickkopf 3 (LOC657143), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 2281 3.9e-255 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.30978 BP_3 6.00 0.82 643 642928696 XP_008199742.1 450 2.8e-42 PREDICTED: uncharacterized protein LOC662585 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30979 BP_3 4.00 0.48 692 557745700 AHA33380.1 732 5.9e-75 odorant-binding protein 2 [Batocera horsfieldi] 557745699 KC461116.1 405 0 Batocera horsfieldi odorant-binding protein 2 (obp2) mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.30980 BP_3 197.00 2.81 3667 765527265 AJS10721.1 581 1.0e-56 14-3-3 epsilon [Tenebrio molitor] 346713643 AK386529.1 218 1.08535e-107 Bombyx mori mRNA, clone: fprW12H08 K06630 YWHAE 14-3-3 protein epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K06630 P62262 573 3.5e-57 14-3-3 protein epsilon OS=Ovis aries GN=YWHAE PE=1 SV=1 PF00060//PF08038 Ligand-gated ion channel//TOM7 family GO:0006811//GO:0030150//GO:0007268//GO:0007165 ion transport//protein import into mitochondrial matrix//synaptic transmission//signal transduction GO:0004970 ionotropic glutamate receptor activity GO:0005742//GO:0016020 mitochondrial outer membrane translocase complex//membrane KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.30984 BP_3 50.81 1.16 2406 478263070 ENN81470.1 1555 7.6e-170 hypothetical protein YQE_02162, partial [Dendroctonus ponderosae]>gi|546686023|gb|ERL95423.1| hypothetical protein D910_12687 [Dendroctonus ponderosae] 620970074 XM_001518444.3 46 2.91664e-12 PREDICTED: Ornithorhynchus anatinus carbohydrate sulfotransferase 13-like (LOC100088952), partial mRNA K01017 CHST11 chondroitin 4-sulfotransferase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K01017 Q7T3S3 541 1.2e-53 Carbohydrate sulfotransferase 11 OS=Danio rerio GN=chst11 PE=2 SV=1 PF00240//PF03567 Ubiquitin family//Sulfotransferase family -- -- GO:0005515//GO:0008146 protein binding//sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30985 BP_3 43.28 1.05 2286 478263070 ENN81470.1 1555 7.2e-170 hypothetical protein YQE_02162, partial [Dendroctonus ponderosae]>gi|546686023|gb|ERL95423.1| hypothetical protein D910_12687 [Dendroctonus ponderosae] 620970074 XM_001518444.3 46 2.76903e-12 PREDICTED: Ornithorhynchus anatinus carbohydrate sulfotransferase 13-like (LOC100088952), partial mRNA K01017 CHST11 chondroitin 4-sulfotransferase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K01017 Q7T3S3 541 1.1e-53 Carbohydrate sulfotransferase 11 OS=Danio rerio GN=chst11 PE=2 SV=1 PF00240//PF03567 Ubiquitin family//Sulfotransferase family -- -- GO:0008146//GO:0005515 sulfotransferase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.30986 BP_3 67.91 1.63 2299 478263070 ENN81470.1 1555 7.3e-170 hypothetical protein YQE_02162, partial [Dendroctonus ponderosae]>gi|546686023|gb|ERL95423.1| hypothetical protein D910_12687 [Dendroctonus ponderosae] 620970074 XM_001518444.3 46 2.78502e-12 PREDICTED: Ornithorhynchus anatinus carbohydrate sulfotransferase 13-like (LOC100088952), partial mRNA K01017 CHST11 chondroitin 4-sulfotransferase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K01017 Q7T3S3 541 1.1e-53 Carbohydrate sulfotransferase 11 OS=Danio rerio GN=chst11 PE=2 SV=1 PF03567//PF00240 Sulfotransferase family//Ubiquitin family -- -- GO:0008146//GO:0005515 sulfotransferase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.30987 BP_3 30.89 0.82 2101 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03851 UV-endonuclease UvdE GO:0006289//GO:0009411 nucleotide-excision repair//response to UV GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.30988 BP_3 30.56 0.83 2056 91082695 XP_971685.1 967 9.9e-102 PREDICTED: protein disulfide-isomerase A3 [Tribolium castaneum]>gi|270014973|gb|EFA11421.1| hypothetical protein TcasGA2_TC013598 [Tribolium castaneum] 354548260 HE605209.1 38 6.96135e-08 Candida parapsilosis strain CDC317 annotated contig 006110 K08056 PDIA3, GRP58 protein disulfide isomerase family A, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08056 Q8JG64 501 4.4e-49 Protein disulfide-isomerase A3 OS=Gallus gallus GN=PDIA3 PE=2 SV=1 PF00085//PF00578 Thioredoxin//AhpC/TSA family GO:0006662//GO:0006118//GO:0045454//GO:0055114 glycerol ether metabolic process//obsolete electron transport//cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0016853//GO:0015035//GO:0016209//GO:0009055 oxidoreductase activity//isomerase activity//protein disulfide oxidoreductase activity//antioxidant activity//electron carrier activity GO:0005783 endoplasmic reticulum KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.30989 BP_3 7556.77 165.01 2499 91082695 XP_971685.1 2147 1.8e-238 PREDICTED: protein disulfide-isomerase A3 [Tribolium castaneum]>gi|270014973|gb|EFA11421.1| hypothetical protein TcasGA2_TC013598 [Tribolium castaneum] 354548260 HE605209.1 38 8.48727e-08 Candida parapsilosis strain CDC317 annotated contig 006110 K08056 PDIA3, GRP58 protein disulfide isomerase family A, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08056 Q8JG64 1232 9.2e-134 Protein disulfide-isomerase A3 OS=Gallus gallus GN=PDIA3 PE=2 SV=1 PF08534//PF00085//PF00462//PF00578 Redoxin//Thioredoxin//Glutaredoxin//AhpC/TSA family GO:0006118//GO:0055114//GO:0045454//GO:0006662 obsolete electron transport//oxidation-reduction process//cell redox homeostasis//glycerol ether metabolic process GO:0009055//GO:0016209//GO:0015035//GO:0016853//GO:0016491 electron carrier activity//antioxidant activity//protein disulfide oxidoreductase activity//isomerase activity//oxidoreductase activity GO:0005783 endoplasmic reticulum KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.30991 BP_3 1622.00 16.25 5103 478255672 ENN75884.1 2568 5.5e-287 hypothetical protein YQE_07613, partial [Dendroctonus ponderosae]>gi|546678103|gb|ERL88812.1| hypothetical protein D910_06194 [Dendroctonus ponderosae]>gi|546687720|gb|ERL96280.1| hypothetical protein D910_01703 [Dendroctonus ponderosae] -- -- -- -- -- K06515 SLC44A1, CDW92 solute carrier family 44 (choline transporter-like protein), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06515 Q9VZE7 1555 6.6e-171 CTL-like protein 1 OS=Drosophila melanogaster GN=CG1311 PE=2 SV=1 PF02112 cAMP phosphodiesterases class-II GO:0006198 cAMP catabolic process GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity -- -- KOG2971 RNA-binding protein required for biogenesis of the ribosomal 60S subunit Cluster-8309.30992 BP_3 34.73 0.45 3982 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04805//PF00042//PF03106 E10-like protein conserved region//Globin//WRKY DNA -binding domain GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0019825//GO:0016972//GO:0020037//GO:0003700//GO:0043565 oxygen binding//thiol oxidase activity//heme binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.30993 BP_3 43.07 0.34 6438 642929205 XP_008195735.1 3696 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 554 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q9Y4E6 1822 9.2e-202 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF00784//PF00400//PF01506//PF07569 MyTH4 domain//WD domain, G-beta repeat//Hepatitis C virus non-structural 5a protein membrane anchor//TUP1-like enhancer of split GO:0006355//GO:0006508//GO:0006144 regulation of transcription, DNA-templated//proteolysis//purine nucleobase metabolic process GO:0004197//GO:0017111//GO:0004252//GO:0003968//GO:0005515 cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//RNA-directed RNA polymerase activity//protein binding GO:0031379//GO:0005634//GO:0005856 RNA-directed RNA polymerase complex//nucleus//cytoskeleton KOG4155 FOG: WD40 repeat Cluster-8309.30994 BP_3 25.00 1.71 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30996 BP_3 8625.49 166.81 2784 91089337 XP_972494.1 2610 4.1e-292 PREDICTED: protein singed [Tribolium castaneum]>gi|270012518|gb|EFA08966.1| hypothetical protein TcasGA2_TC006673 [Tribolium castaneum] 642933078 XM_967401.2 574 0 PREDICTED: Tribolium castaneum protein singed (LOC661226), mRNA K17455 FSCN1_2 fascin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17455 Q24524 1954 2.0e-217 Protein singed OS=Drosophila melanogaster GN=sn PE=3 SV=1 PF00167//PF06268//PF01529//PF01786 Fibroblast growth factor//Fascin domain//DHHC palmitoyltransferase//Alternative oxidase GO:0040007//GO:0007165//GO:0008283//GO:0006118//GO:0055114 growth//signal transduction//cell proliferation//obsolete electron transport//oxidation-reduction process GO:0008083//GO:0009916//GO:0051015//GO:0008270//GO:0030674 growth factor activity//alternative oxidase activity//actin filament binding//zinc ion binding//protein binding, bridging -- -- -- -- Cluster-8309.30997 BP_3 10.38 1.48 630 478255100 ENN75330.1 460 1.9e-43 hypothetical protein YQE_08107, partial [Dendroctonus ponderosae] -- -- -- -- -- K01890 FARSB, pheT phenylalanyl-tRNA synthetase beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K01890 Q9VCA5 399 9.1e-38 Phenylalanine--tRNA ligase beta subunit OS=Drosophila melanogaster GN=beta-PheRS PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2472 Phenylalanyl-tRNA synthetase beta subunit Cluster-8309.31 BP_3 20.10 0.72 1628 831314739 XP_012689951.1 272 3.0e-21 PREDICTED: protein-tyrosine kinase 6-like [Clupea harengus] -- -- -- -- -- -- -- -- -- O08680 258 5.3e-21 Ephrin type-A receptor 3 OS=Rattus norvegicus GN=Epha3 PE=2 SV=1 PF07714//PF00069//PF01007 Protein tyrosine kinase//Protein kinase domain//Inward rectifier potassium channel GO:0006468//GO:0006813 protein phosphorylation//potassium ion transport GO:0005524//GO:0005242//GO:0004672 ATP binding//inward rectifier potassium channel activity//protein kinase activity GO:0016021//GO:0008076 integral component of membrane//voltage-gated potassium channel complex -- -- Cluster-8309.310 BP_3 18.00 1.15 1044 641649457 XP_008186020.1 480 1.5e-45 PREDICTED: uncharacterized protein LOC103310231 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.31000 BP_3 55.43 1.90 1699 91087061 XP_974794.1 923 1.0e-96 PREDICTED: retrograde Golgi transport protein RGP1 homolog [Tribolium castaneum]>gi|270010531|gb|EFA06979.1| hypothetical protein TcasGA2_TC009939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9P3 346 3.4e-31 RAB6A-GEF complex partner protein 2 OS=Bos taurus GN=RGP1 PE=2 SV=1 PF04216 Protein involved in formate dehydrogenase formation -- -- -- -- GO:0005737 cytoplasm -- -- Cluster-8309.31001 BP_3 32.00 0.99 1855 642910336 XP_008200288.1 2075 3.0e-230 PREDICTED: equilibrative nucleoside transporter 4 [Tribolium castaneum]>gi|270014915|gb|EFA11363.1| hypothetical protein TcasGA2_TC011520 [Tribolium castaneum] -- -- -- -- -- K03323 SLC29A4, ENT4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03323 A1L272 877 1.0e-92 Equilibrative nucleoside transporter 4 OS=Danio rerio GN=slc29a4 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.31002 BP_3 2260.37 33.96 3500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00977 Histidine biosynthesis protein GO:0000105 histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.31004 BP_3 196.40 1.52 6516 642932520 XP_008197148.1 1026 4.5e-108 PREDICTED: LOW QUALITY PROTEIN: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00627 DLAT, aceF, pdhC pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) http://www.genome.jp/dbget-bin/www_bget?ko:K00627 P08461 786 1.3e-81 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Rattus norvegicus GN=Dlat PE=1 SV=3 PF06314//PF00198//PF01588//PF02817 Acetoacetate decarboxylase (ADC)//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Putative tRNA binding domain//e3 binding domain GO:0008152 metabolic process GO:0000049//GO:0016829//GO:0016746 tRNA binding//lyase activity//transferase activity, transferring acyl groups -- -- KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.31005 BP_3 1.00 2.65 285 641649148 XP_008184923.1 135 4.1e-06 PREDICTED: uncharacterized protein K02A2.6-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31006 BP_3 27.13 0.64 2324 26324131 AAN77377.1 2702 7.3e-303 smooth endoplasmic reticulum calcium ATPase [Porcellio scaber] 378947922 JN986572.1 801 0 Litopenaeus vannamei sarco/endoplasmic reticulum Ca2+-ATPase mRNA, complete cds K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 Q7PPA5 2456 1.0e-275 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Anopheles gambiae GN=Ca-P60A PE=3 SV=5 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.31008 BP_3 293.49 1.64 8901 617652370 XP_007534385.1 565 1.8e-54 PREDICTED: zinc finger protein 14-like [Erinaceus europaeus] -- -- -- -- -- -- -- -- -- Q03938 512 1.0e-49 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF16622//PF07776//PF13912//PF00230//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Major intrinsic protein//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006810 transport GO:0008270//GO:0046872//GO:0005215 zinc ion binding//metal ion binding//transporter activity GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.31009 BP_3 90.90 1.32 3603 189237997 XP_001812912.1 1051 3.2e-111 PREDICTED: dehydrogenase/reductase SDR family protein 7-like [Tribolium castaneum]>gi|270006651|gb|EFA03099.1| hypothetical protein TcasGA2_TC013008 [Tribolium castaneum] -- -- -- -- -- K11166 DHRS7B dehydrogenase/reductase SDR family member 7B http://www.genome.jp/dbget-bin/www_bget?ko:K11166 Q7Q732 796 4.8e-83 Dehydrogenase/reductase SDR family protein 7-like OS=Anopheles gambiae GN=AGAP005532 PE=3 SV=3 PF14972//PF01370//PF00106//PF02882//PF12242//PF02558 Mitochondrial morphogenesis regulator//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Ketopantoate reductase PanE/ApbA GO:0007005//GO:0055114//GO:0009396//GO:0046487//GO:0008152//GO:0015940 mitochondrion organization//oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//metabolic process//pantothenate biosynthetic process GO:0008677//GO:0016491//GO:0004488//GO:0050662//GO:0003824 2-dehydropantoate 2-reductase activity//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//coenzyme binding//catalytic activity GO:0031305 integral component of mitochondrial inner membrane KOG1205 Predicted dehydrogenase Cluster-8309.31010 BP_3 176.02 6.59 1580 189242434 XP_967120.2 498 1.8e-47 PREDICTED: thioredoxin domain-containing protein 17-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DBT3 289 1.3e-24 Thioredoxin domain-containing protein 17 OS=Danio rerio GN=txndc17 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3425 Uncharacterized conserved protein Cluster-8309.31011 BP_3 62.60 1.15 2916 91092242 XP_971366.1 1543 2.3e-168 PREDICTED: protein ariadne-2 [Tribolium castaneum]>gi|270014427|gb|EFA10875.1| hypothetical protein TcasGA2_TC001697 [Tribolium castaneum] 462373241 APGK01024814.1 149 1.95805e-69 Dendroctonus ponderosae Seq01024824, whole genome shotgun sequence K11969 ARIH2 ariadne-2 http://www.genome.jp/dbget-bin/www_bget?ko:K11969 O76924 1271 3.2e-138 Protein ariadne-2 OS=Drosophila melanogaster GN=ari-2 PE=2 SV=1 PF00097//PF09749//PF14634//PF13639 Zinc finger, C3HC4 type (RING finger)//Uncharacterised conserved protein//zinc-RING finger domain//Ring finger domain GO:0034477 U6 snRNA 3'-end processing GO:0008270//GO:0004518//GO:0046872//GO:0005515 zinc ion binding//nuclease activity//metal ion binding//protein binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.31012 BP_3 382.40 2.93 6572 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 3.1e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF00448//PF03193//PF00005//PF02367//PF13304//PF01926 SRP54-type protein, GTPase domain//Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006614//GO:0002949//GO:0006200 SRP-dependent cotranslational protein targeting to membrane//tRNA threonylcarbamoyladenosine modification//obsolete ATP catabolic process GO:0016887//GO:0005525//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATP binding//GTPase activity -- -- -- -- Cluster-8309.31013 BP_3 62.76 0.46 6853 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 3.2e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF00448//PF02367//PF01926//PF13304//PF03193//PF00005 SRP54-type protein, GTPase domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function, DUF258//ABC transporter GO:0002949//GO:0006614//GO:0006200 tRNA threonylcarbamoyladenosine modification//SRP-dependent cotranslational protein targeting to membrane//obsolete ATP catabolic process GO:0016887//GO:0005524//GO:0005525//GO:0003924 ATPase activity//ATP binding//GTP binding//GTPase activity -- -- -- -- Cluster-8309.31014 BP_3 591.11 4.61 6477 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 3.0e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF13304//PF02367//PF01926//PF03193//PF00005//PF00448 AAA domain, putative AbiEii toxin, Type IV TA system//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase//Protein of unknown function, DUF258//ABC transporter//SRP54-type protein, GTPase domain GO:0006200//GO:0006614//GO:0002949 obsolete ATP catabolic process//SRP-dependent cotranslational protein targeting to membrane//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0005525//GO:0005524//GO:0016887 GTPase activity//GTP binding//ATP binding//ATPase activity -- -- -- -- Cluster-8309.31015 BP_3 133.24 1.12 6032 642923453 XP_008193751.1 3987 0.0e+00 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1409 6.7e-154 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF00400//PF02460 WD domain, G-beta repeat//Patched family GO:0007165 signal transduction GO:0005515//GO:0008158 protein binding//hedgehog receptor activity GO:0016020 membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.31016 BP_3 408.70 10.54 2160 478257576 ENN77730.1 2153 3.1e-239 hypothetical protein YQE_05801, partial [Dendroctonus ponderosae] -- -- -- -- -- K12261 HACL1 2-hydroxyacyl-CoA lyase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12261 Q8CHM7 1444 2.1e-158 2-hydroxyacyl-CoA lyase 1 OS=Rattus norvegicus GN=Hacl1 PE=1 SV=1 PF02776//PF02775//PF00205//PF02552 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Thiamine pyrophosphate enzyme, central domain//CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit GO:0019385 methanogenesis, from acetate GO:0030976//GO:0000287//GO:0003824 thiamine pyrophosphate binding//magnesium ion binding//catalytic activity -- -- KOG1185 Thiamine pyrophosphate-requiring enzyme Cluster-8309.31017 BP_3 147.93 1.27 5895 91082033 XP_970590.1 2741 5.6e-307 PREDICTED: tyrosine-protein phosphatase non-receptor type 23 [Tribolium castaneum]>gi|642921972|ref|XP_008192966.1| PREDICTED: tyrosine-protein phosphatase non-receptor type 23 [Tribolium castaneum] 801384853 XM_012200272.1 35 9.38654e-06 PREDICTED: Atta cephalotes tyrosine-protein phosphatase non-receptor type 23 (LOC105618741), mRNA K18040 PTPN23 tyrosine-protein phosphatase non-receptor type 23 http://www.genome.jp/dbget-bin/www_bget?ko:K18040 Q6PB44 1409 6.5e-154 Tyrosine-protein phosphatase non-receptor type 23 OS=Mus musculus GN=Ptpn23 PE=1 SV=2 PF00102//PF13949//PF00782 Protein-tyrosine phosphatase//ALIX V-shaped domain binding to HIV//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding -- -- KOG2220 Predicted signal transduction protein Cluster-8309.31020 BP_3 400.56 6.73 3161 642926739 XP_008194992.1 1564 9.0e-171 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X2 [Tribolium castaneum] 611988503 XM_007481079.1 71 4.86678e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 960 4.1e-102 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF13180//PF00595//PF00610 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG3571 Dishevelled 3 and related proteins Cluster-8309.31021 BP_3 156.00 3.05 2753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31022 BP_3 65.66 0.45 7294 642918310 XP_008191453.1 3445 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] 731493282 XM_010593680.1 38 2.49811e-07 PREDICTED: Loxodonta africana inositol polyphosphate-4-phosphatase, type I, 107kDa (INPP4A), mRNA K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 O15327 545 1.2e-53 Type II inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4B PE=2 SV=4 PF00010//PF01017//PF00168//PF01530//PF02106 Helix-loop-helix DNA-binding domain//STAT protein, all-alpha domain//C2 domain//Zinc finger, C2HC type//Fanconi anaemia group C protein GO:0007165//GO:0006281//GO:0006355 signal transduction//DNA repair//regulation of transcription, DNA-templated GO:0005515//GO:0046983//GO:0004871//GO:0008270//GO:0003700 protein binding//protein dimerization activity//signal transducer activity//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.31025 BP_3 13.84 0.45 1774 642938573 XP_969296.2 970 3.8e-102 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum]>gi|642938575|ref|XP_008199847.1| PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 720 1.5e-74 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.31028 BP_3 644.81 7.15 4637 817068525 XP_012256206.1 1118 6.9e-119 PREDICTED: matrix metalloproteinase-25-like [Athalia rosae] -- -- -- -- -- K07997 MMP17 matrix metalloproteinase-17 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07997 Q3U435 412 2.1e-38 Matrix metalloproteinase-25 OS=Mus musculus GN=Mmp25 PE=2 SV=1 PF10462//PF00413//PF01400 Peptidase M66//Matrixin//Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.31029 BP_3 280.00 5.92 2571 642917332 XP_008199257.1 1708 1.5e-187 PREDICTED: rac GTPase-activating protein 1 [Tribolium castaneum]>gi|642917334|ref|XP_008199258.1| PREDICTED: rac GTPase-activating protein 1 [Tribolium castaneum] -- -- -- -- -- K16733 RACGAP1, Tum Rac GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16733 Q9H0H5 913 9.3e-97 Rac GTPase-activating protein 1 OS=Homo sapiens GN=RACGAP1 PE=1 SV=1 PF00620//PF00130//PF15898 RhoGAP domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//cGMP-dependent protein kinase interacting domain GO:0035556//GO:0007165 intracellular signal transduction//signal transduction GO:0019901 protein kinase binding -- -- KOG3564 GTPase-activating protein Cluster-8309.31035 BP_3 981.00 25.95 2114 642922153 XP_008193036.1 996 4.4e-105 PREDICTED: afadin isoform X1 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31036 BP_3 65.01 0.90 3765 642922155 XP_008193037.1 3957 0.0e+00 PREDICTED: afadin isoform X2 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 Q9QZQ1 1341 3.2e-146 Afadin OS=Mus musculus GN=Mllt4 PE=1 SV=3 PF00595//PF00498//PF13180//PF16011 PDZ domain (Also known as DHR or GLGF)//FHA domain//PDZ domain//Carbohydrate-binding family 9 GO:0005975//GO:0016052 carbohydrate metabolic process//carbohydrate catabolic process GO:0005515//GO:0030246//GO:0004553 protein binding//carbohydrate binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1892 Actin filament-binding protein Afadin Cluster-8309.31037 BP_3 60.19 0.69 4468 642922153 XP_008193036.1 4275 0.0e+00 PREDICTED: afadin isoform X1 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 Q9QZQ1 1399 7.1e-153 Afadin OS=Mus musculus GN=Mllt4 PE=1 SV=3 PF13180//PF00595//PF00498//PF16011 PDZ domain//PDZ domain (Also known as DHR or GLGF)//FHA domain//Carbohydrate-binding family 9 GO:0016052//GO:0005975 carbohydrate catabolic process//carbohydrate metabolic process GO:0004553//GO:0030246//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding//protein binding -- -- KOG1892 Actin filament-binding protein Afadin Cluster-8309.31038 BP_3 760.85 5.78 6638 642922153 XP_008193036.1 5647 0.0e+00 PREDICTED: afadin isoform X1 [Tribolium castaneum] 462316425 APGK01045079.1 64 8.001e-22 Dendroctonus ponderosae Seq01045089, whole genome shotgun sequence K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 P55196 2099 7.2e-234 Afadin OS=Homo sapiens GN=MLLT4 PE=1 SV=3 PF16011//PF00788//PF08272//PF00595//PF00498//PF13180//PF04977 Carbohydrate-binding family 9//Ras association (RalGDS/AF-6) domain//Topoisomerase I zinc-ribbon-like//PDZ domain (Also known as DHR or GLGF)//FHA domain//PDZ domain//Septum formation initiator GO:0016052//GO:0007049//GO:0006265//GO:0005975//GO:0007165 carbohydrate catabolic process//cell cycle//DNA topological change//carbohydrate metabolic process//signal transduction GO:0003918//GO:0030246//GO:0005515//GO:0004553//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//carbohydrate binding//protein binding//hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding GO:0005694 chromosome KOG1892 Actin filament-binding protein Afadin Cluster-8309.3104 BP_3 11.00 0.66 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31043 BP_3 461.00 19.94 1406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31045 BP_3 1722.88 22.54 3976 189242201 XP_972508.2 887 3.6e-92 PREDICTED: protein suppressor of white apricot, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12297 432 8.6e-41 Protein suppressor of white apricot OS=Drosophila melanogaster GN=su(w[a]) PE=1 SV=3 PF01805//PF04277//PF07127 Surp module//Oxaloacetate decarboxylase, gamma chain//Late nodulin protein GO:0006525//GO:0006560//GO:0006090//GO:0009878//GO:0071436//GO:0006814//GO:0006396 arginine metabolic process//proline metabolic process//pyruvate metabolic process//nodule morphogenesis//sodium ion export//sodium ion transport//RNA processing GO:0003723//GO:0008948//GO:0046872//GO:0015081 RNA binding//oxaloacetate decarboxylase activity//metal ion binding//sodium ion transmembrane transporter activity GO:0016020 membrane KOG1847 mRNA splicing factor Cluster-8309.31049 BP_3 341.00 19.33 1142 270001371 EEZ97818.1 226 4.6e-16 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914994 XM_008192253.1 106 6.03687e-46 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X5, mRNA -- -- -- -- Q7TMK9 139 2.3e-07 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.31050 BP_3 950.79 14.92 3363 91093162 XP_967461.1 1758 3.1e-193 PREDICTED: nucleolar complex protein 4 homolog B [Tribolium castaneum]>gi|270012948|gb|EFA09396.1| hypothetical protein TcasGA2_TC004314 [Tribolium castaneum] -- -- -- -- -- K14771 NOC4, UTP19 U3 small nucleolar RNA-associated protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K14771 Q6NRQ2 650 3.8e-66 Nucleolar complex protein 4 homolog A OS=Xenopus laevis GN=noc4l-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2154 Predicted nucleolar protein involved in ribosome biogenesis Cluster-8309.31051 BP_3 40.76 0.55 3875 91082907 XP_972373.1 1236 1.2e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.9e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF12740//PF00326//PF10503//PF00787//PF07224 Chlorophyllase enzyme//Prolyl oligopeptidase family//Esterase PHB depolymerase//PX domain//Chlorophyllase GO:0006508//GO:0046294//GO:0015994//GO:0015996//GO:0015947 proteolysis//formaldehyde catabolic process//chlorophyll metabolic process//chlorophyll catabolic process//methane metabolic process GO:0008236//GO:0018738//GO:0035091//GO:0047746 serine-type peptidase activity//S-formylglutathione hydrolase activity//phosphatidylinositol binding//chlorophyllase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.31052 BP_3 17.22 1.36 904 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31053 BP_3 36.00 0.39 4795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31054 BP_3 95.94 2.26 2335 642939351 XP_008197109.1 804 9.0e-83 PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum]>gi|642939353|ref|XP_008197119.1| PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31055 BP_3 363.85 41.43 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31056 BP_3 30.97 0.96 1847 91085997 XP_972384.1 838 8.1e-87 PREDICTED: cyclin-related protein FAM58A [Tribolium castaneum]>gi|270010183|gb|EFA06631.1| hypothetical protein TcasGA2_TC009550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4QQW5 397 4.6e-37 Cyclin-related protein FAM58A OS=Rattus norvegicus GN=Fam58a PE=2 SV=1 PF02984 Cyclin, C-terminal domain GO:0000079//GO:0006355 regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0005634 nucleus -- -- Cluster-8309.31060 BP_3 3014.76 127.55 1431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03286//PF02178 Pox virus Ag35 surface protein//AT hook motif -- -- GO:0003677 DNA binding GO:0019031 viral envelope -- -- Cluster-8309.31062 BP_3 547.00 29.09 1198 873236768 CEL98446.1 637 1.1e-63 unnamed protein product [Vitrella brassicaformis CCMP3155] 70909910 AM049142.1 149 7.90946e-70 Carabus granulatus mRNA for ribosomal protein Ubq/L40e (ubiquitin/rpL40e gene) K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P0CH06 621 3.1e-63 Ubiquitin-60S ribosomal protein L40 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubi1 PE=1 SV=1 PF01020//PF14560//PF00240 Ribosomal L40e family//Ubiquitin-like domain//Ubiquitin family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-8309.31065 BP_3 306.10 5.83 2821 91080457 XP_969840.1 1905 2.3e-210 PREDICTED: TBC1 domain family member 15 [Tribolium castaneum]>gi|270005762|gb|EFA02210.1| hypothetical protein TcasGA2_TC007868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CXF4 982 1.0e-104 TBC1 domain family member 15 OS=Mus musculus GN=Tbc1d15 PE=1 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.31066 BP_3 290.95 10.57 1619 478250454 ENN70949.1 770 5.4e-79 hypothetical protein YQE_12350, partial [Dendroctonus ponderosae]>gi|546677323|gb|ERL88180.1| hypothetical protein D910_05568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31067 BP_3 21.94 1.70 912 478250454 ENN70949.1 223 8.2e-16 hypothetical protein YQE_12350, partial [Dendroctonus ponderosae]>gi|546677323|gb|ERL88180.1| hypothetical protein D910_05568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31068 BP_3 20.03 1.39 987 642931239 XP_971757.2 452 2.5e-42 PREDICTED: enoyl-CoA hydratase, mitochondrial [Tribolium castaneum] 589950009 XM_006987599.1 41 7.05774e-10 PREDICTED: Peromyscus maniculatus bairdii enoyl CoA hydratase, short chain, 1, mitochondrial (Echs1), mRNA K07511 ECHS1 enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K07511 P14604 348 1.2e-31 Enoyl-CoA hydratase, mitochondrial OS=Rattus norvegicus GN=Echs1 PE=1 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.3107 BP_3 37.10 2.07 1154 642914631 XP_008190292.1 393 2.0e-35 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0003676//GO:0016787//GO:0046872 nucleic acid binding//hydrolase activity//metal ion binding -- -- -- -- Cluster-8309.31071 BP_3 9.00 0.86 795 642927986 XP_008195473.1 293 5.5e-24 PREDICTED: uncharacterized protein LOC103313592 [Tribolium castaneum]>gi|270010273|gb|EFA06721.1| hypothetical protein TcasGA2_TC009652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31072 BP_3 64.00 3.36 1210 478257154 ENN77317.1 341 2.3e-29 hypothetical protein YQE_06143, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31074 BP_3 94.40 2.55 2079 642915202 XP_008190517.1 275 1.7e-21 PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum]>gi|642915204|ref|XP_008190519.1| PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31075 BP_3 302.00 49.46 586 91078158 XP_973931.1 545 2.4e-53 PREDICTED: 14 kDa phosphohistidine phosphatase [Tribolium castaneum]>gi|270002348|gb|EEZ98795.1| hypothetical protein TcasGA2_TC001359 [Tribolium castaneum] -- -- -- -- -- K01112 PHPT1 phosphohistidine phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01112 Q32PA4 311 1.4e-27 14 kDa phosphohistidine phosphatase OS=Bos taurus GN=PHPT1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31076 BP_3 241.17 5.89 2265 478262409 ENN81080.1 851 3.1e-88 hypothetical protein YQE_02449, partial [Dendroctonus ponderosae] -- -- -- -- -- K06633 PKMYT membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06633 Q9NI63 527 4.7e-52 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase OS=Drosophila melanogaster GN=Myt1 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0601 Cyclin-dependent kinase WEE1 Cluster-8309.31077 BP_3 326.83 6.62 2671 478262409 ENN81080.1 851 3.6e-88 hypothetical protein YQE_02449, partial [Dendroctonus ponderosae] -- -- -- -- -- K06633 PKMYT membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06633 Q9NI63 527 5.5e-52 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase OS=Drosophila melanogaster GN=Myt1 PE=1 SV=2 PF00069//PF08138//PF07714 Protein kinase domain//Sex peptide (SP) family//Protein tyrosine kinase GO:0006468//GO:0046008//GO:0007165 protein phosphorylation//regulation of female receptivity, post-mating//signal transduction GO:0004672//GO:0005179//GO:0005524 protein kinase activity//hormone activity//ATP binding GO:0005576 extracellular region KOG0601 Cyclin-dependent kinase WEE1 Cluster-8309.31078 BP_3 113.26 4.65 1466 724970788 XP_010357705.1 695 2.4e-70 PREDICTED: myosin light chain alkali-like [Rhinopithecus roxellana] 724970787 XM_010359403.1 423 0 PREDICTED: Rhinopithecus roxellana myosin light chain alkali-like (LOC104659290), mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24756 399 2.1e-37 Myosin light chain alkali OS=Drosophila virilis GN=Mlc1 PE=3 SV=1 PF00036//PF13405//PF13499 EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.31079 BP_3 837.45 21.64 2157 642931776 XP_008196723.1 2390 1.0e-266 PREDICTED: alkyldihydroxyacetonephosphate synthase [Tribolium castaneum]>gi|270012218|gb|EFA08666.1| hypothetical protein TcasGA2_TC006332 [Tribolium castaneum] -- -- -- -- -- K00803 AGPS, agpS alkyldihydroxyacetonephosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00803 Q9V778 1848 3.0e-205 Alkyldihydroxyacetonephosphate synthase OS=Drosophila melanogaster GN=CG10253 PE=2 SV=1 PF02913//PF01565 FAD linked oxidases, C-terminal domain//FAD binding domain GO:0046486//GO:0055114//GO:0008610//GO:0006040 glycerolipid metabolic process//oxidation-reduction process//lipid biosynthetic process//amino sugar metabolic process GO:0050660//GO:0008762//GO:0016491//GO:0008609//GO:0003824 flavin adenine dinucleotide binding//UDP-N-acetylmuramate dehydrogenase activity//oxidoreductase activity//alkylglycerone-phosphate synthase activity//catalytic activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.3108 BP_3 45.53 2.17 1304 642914631 XP_008190292.1 393 2.3e-35 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0046872//GO:0003676//GO:0016787 metal ion binding//nucleic acid binding//hydrolase activity -- -- -- -- Cluster-8309.31081 BP_3 50.99 10.14 534 642912272 XP_008200632.1 255 9.3e-20 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 130 1.2e-06 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31083 BP_3 234.32 4.05 3083 642912272 XP_008200632.1 657 1.3e-65 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 279 3.7e-23 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF00757 Trypsin//Furin-like cysteine rich region GO:0006508//GO:0006468//GO:0007169 proteolysis//protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0004252//GO:0004714 ATP binding//serine-type endopeptidase activity//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane -- -- Cluster-8309.31085 BP_3 4.00 1.71 403 170321839 BAG14264.1 168 8.6e-10 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31086 BP_3 35.05 1.83 1216 150416593 ABF60889.2 189 9.6e-12 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31089 BP_3 1041.15 6.64 7852 642918656 XP_008191524.1 2229 1.7e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.2e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF00069//PF01799//PF00433//PF07714//PF07535//PF06220//PF00463 Protein kinase domain//[2Fe-2S] binding domain//Protein kinase C terminal domain//Protein tyrosine kinase//DBF zinc finger//U1 zinc finger//Isocitrate lyase family GO:0006097//GO:0055114//GO:0006468//GO:0009069//GO:0016310//GO:0019752 glyoxylate cycle//oxidation-reduction process//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//carboxylic acid metabolic process GO:0008270//GO:0003676//GO:0046872//GO:0004674//GO:0004672//GO:0005524//GO:0005543//GO:0016491//GO:0004451 zinc ion binding//nucleic acid binding//metal ion binding//protein serine/threonine kinase activity//protein kinase activity//ATP binding//phospholipid binding//oxidoreductase activity//isocitrate lyase activity -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.31091 BP_3 1050.58 42.98 1470 820848889 XP_012342205.1 150 3.9e-07 PREDICTED: LOW QUALITY PROTEIN: thyroid transcription factor 1-associated protein 26 [Apis florea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31093 BP_3 197.90 2.40 4272 91085875 XP_966911.1 1172 3.5e-125 PREDICTED: pentatricopeptide repeat-containing protein 2, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ55 357 4.6e-32 Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus GN=PTCD2 PE=2 SV=1 PF05049//PF04750//PF11380 Interferon-inducible GTPase (IIGP)//FAR-17a/AIG1-like protein//Stealth protein CR2, conserved region 2 -- -- GO:0005525//GO:0016772 GTP binding//transferase activity, transferring phosphorus-containing groups GO:0016021//GO:0016020 integral component of membrane//membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.31094 BP_3 10.00 5.73 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00757 Furin-like cysteine rich region GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0004714 ATP binding//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane -- -- Cluster-8309.31095 BP_3 66.00 4.99 929 768450756 XP_011567537.1 309 8.9e-26 PREDICTED: coagulation factor IX-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q90WD8 210 1.1e-15 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31096 BP_3 556.00 21.54 1536 642935236 XP_968858.3 1047 3.9e-111 PREDICTED: RNA methyltransferase-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q566V3 473 5.8e-46 rRNA methyltransferase 3A, mitochondrial OS=Danio rerio GN=rnmtl1a PE=2 SV=1 PF08032//PF00588 RNA 2'-O ribose methyltransferase substrate binding//SpoU rRNA Methylase family GO:0006396//GO:0009451 RNA processing//RNA modification GO:0008173//GO:0003723//GO:0008168 RNA methyltransferase activity//RNA binding//methyltransferase activity -- -- -- -- Cluster-8309.31097 BP_3 21.43 0.38 3010 190702371 ACE75264.1 1332 6.9e-144 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- P10582 133 3.0e-06 DNA polymerase OS=Zea mays PE=3 SV=1 PF03175//PF06220 DNA polymerase type B, organellar and viral//U1 zinc finger GO:0006260 DNA replication GO:0003677//GO:0008408//GO:0000166//GO:0008270//GO:0003887 DNA binding//3'-5' exonuclease activity//nucleotide binding//zinc ion binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.31098 BP_3 127.41 1.20 5400 270015831 EFA12279.1 790 8.7e-81 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09106//PF08398 Elongation factor SelB, winged helix//Parvovirus coat protein VP1 GO:0006448//GO:0001514 regulation of translational elongation//selenocysteine incorporation GO:0005198//GO:0003723//GO:0003746//GO:0005525 structural molecule activity//RNA binding//translation elongation factor activity//GTP binding GO:0019028//GO:0005737//GO:0005840 viral capsid//cytoplasm//ribosome -- -- Cluster-8309.31099 BP_3 69.21 2.33 1724 642927770 XP_008195398.1 656 9.6e-66 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 145 7.1e-08 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.31100 BP_3 157.50 5.53 1664 642927770 XP_008195398.1 685 4.0e-69 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 145 6.8e-08 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.31103 BP_3 974.00 31.67 1774 91079690 XP_968122.1 1780 4.6e-196 PREDICTED: CDK5 regulatory subunit-associated protein 3 [Tribolium castaneum]>gi|270004493|gb|EFA00941.1| hypothetical protein TcasGA2_TC003848 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLH7 991 5.8e-106 CDK5 regulatory subunit-associated protein 3 OS=Rattus norvegicus GN=Cdk5rap3 PE=1 SV=1 PF10018//PF04152//PF04977 Vitamin-D-receptor interacting Mediator subunit 4//Mre11 DNA-binding presumed domain//Septum formation initiator GO:0007049//GO:0006302//GO:0006357 cell cycle//double-strand break repair//regulation of transcription from RNA polymerase II promoter GO:0030145//GO:0004519//GO:0001104 manganese ion binding//endonuclease activity//RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592 nucleus//mediator complex KOG2607 CDK5 activator-binding protein Cluster-8309.31104 BP_3 47.00 11.36 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31105 BP_3 107.96 0.90 6073 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31106 BP_3 882.70 22.54 2179 170321839 BAG14264.1 720 4.6e-73 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8CFG8 240 8.6e-19 Complement C1s-B subcomponent OS=Mus musculus GN=C1sb PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31107 BP_3 44.00 10.42 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03609 PTS system sorbose-specific iic component GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31108 BP_3 205.98 6.39 1846 642916020 XP_008190860.1 1276 1.3e-137 PREDICTED: GTP-binding protein GEM [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55040 254 1.7e-20 GTP-binding protein GEM OS=Homo sapiens GN=GEM PE=1 SV=1 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.31111 BP_3 53.02 2.04 1543 642916020 XP_008190860.1 1254 3.9e-135 PREDICTED: GTP-binding protein GEM [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55040 254 1.5e-20 GTP-binding protein GEM OS=Homo sapiens GN=GEM PE=1 SV=1 PF08477//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.31113 BP_3 16.20 0.66 1480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06416 Protein of unknown function (DUF1076) GO:0016567//GO:0072519 protein ubiquitination//parasitism GO:0004842 ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.31114 BP_3 43.80 2.40 1172 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06416 Protein of unknown function (DUF1076) GO:0016567//GO:0072519 protein ubiquitination//parasitism GO:0004842 ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.31116 BP_3 16.00 30.86 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31117 BP_3 1762.97 46.07 2136 385845164 AFI81409.1 1440 1.5e-156 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 57 1.98386e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 586 6.4e-59 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF08127//PF03099 Peptidase family C1 propeptide//Biotin/lipoate A/B protein ligase family GO:0006464//GO:0006508//GO:0050790 cellular protein modification process//proteolysis//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.3112 BP_3 4.00 0.52 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31120 BP_3 886.30 18.39 2615 546683891 ERL93639.1 1009 1.7e-106 hypothetical protein D910_10927 [Dendroctonus ponderosae] -- -- -- -- -- K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 Q9NZR2 179 1.2e-11 Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens GN=LRP1B PE=1 SV=2 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.31121 BP_3 336.85 4.16 4191 270010219 EFA06667.1 2551 4.3e-285 hypothetical protein TcasGA2_TC009594 [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 951 5.9e-101 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.31122 BP_3 0.98 0.62 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31124 BP_3 603.00 4.24 7141 102939 2519 3.7e-281 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1517 2.4e-166 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF03539 Integrase core domain//Spumavirus aspartic protease (A9) GO:0006508//GO:0015074 proteolysis//DNA integration GO:0004190 aspartic-type endopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.31125 BP_3 66.24 0.98 3539 91092208 XP_969730.1 777 1.8e-79 PREDICTED: protein unc-50 homolog [Tribolium castaneum]>gi|270014482|gb|EFA10930.1| hypothetical protein TcasGA2_TC001757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VHN5 706 1.3e-72 Protein unc-50 homolog OS=Drosophila melanogaster GN=CG9773 PE=1 SV=1 PF02703 Early E1A protein GO:0019048//GO:0006355 modulation by virus of host morphology or physiology//regulation of transcription, DNA-templated -- -- -- -- KOG3012 Uncharacterized conserved protein Cluster-8309.31126 BP_3 2719.42 71.50 2125 91090858 XP_967143.1 786 1.0e-80 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 603 6.8e-61 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF04546//PF00191 Sigma-70, non-essential region//Annexin GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0016987//GO:0005509//GO:0003700//GO:0005544//GO:0003677 sigma factor activity//calcium ion binding//transcription factor activity, sequence-specific DNA binding//calcium-dependent phospholipid binding//DNA binding GO:0005667 transcription factor complex KOG0819 Annexin Cluster-8309.31127 BP_3 202.91 7.37 1618 91078920 XP_973689.1 883 4.3e-92 PREDICTED: ubiquitin-conjugating enzyme E2 G2 [Tribolium castaneum]>gi|270004881|gb|EFA01329.1| courtless [Tribolium castaneum] 827562182 XM_004933089.2 186 2.90979e-90 PREDICTED: Bombyx mori ubiquitin-conjugating enzyme E2 G2 (LOC101745353), mRNA K04555 UBE2G2, UBC7 ubiquitin-conjugating enzyme E2 G2 http://www.genome.jp/dbget-bin/www_bget?ko:K04555 Q5RF84 769 2.9e-80 Ubiquitin-conjugating enzyme E2 G2 OS=Pongo abelii GN=UBE2G2 PE=2 SV=1 PF05615 Tho complex subunit 7 GO:0006397 mRNA processing GO:0005524//GO:0016881 ATP binding//acid-amino acid ligase activity GO:0000445 THO complex part of transcription export complex KOG0426 Ubiquitin-protein ligase Cluster-8309.31128 BP_3 1906.00 24.21 4086 291463256 NP_001167547.1 3312 0.0e+00 uncharacterized protein LOC100381254 precursor [Tribolium castaneum]>gi|270014696|gb|EFA11144.1| hypothetical protein TcasGA2_TC004746 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GQT9 1063 6.0e-114 Nodal modulator 1 OS=Mus musculus GN=Nomo1 PE=1 SV=1 PF00041//PF00775//PF01105 Fibronectin type III domain//Dioxygenase//emp24/gp25L/p24 family/GOLD GO:0055114//GO:0006725//GO:0006810 oxidation-reduction process//cellular aromatic compound metabolic process//transport GO:0005515//GO:0008199//GO:0003824 protein binding//ferric iron binding//catalytic activity GO:0016021 integral component of membrane KOG1948 Metalloproteinase-related collagenase pM5 Cluster-8309.31132 BP_3 110.41 0.91 6115 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.1e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF13606//PF00023//PF01331//PF09266//PF01279 Ankyrin repeat//Ankyrin repeat//mRNA capping enzyme, catalytic domain//Viral DNA topoisomerase I, N-terminal//Parathyroid hormone family GO:0006397//GO:0007165//GO:0006370//GO:0006265 mRNA processing//signal transduction//7-methylguanosine mRNA capping//DNA topological change GO:0003677//GO:0004484//GO:0005515//GO:0005179//GO:0003916 DNA binding//mRNA guanylyltransferase activity//protein binding//hormone activity//DNA topoisomerase activity GO:0005576 extracellular region -- -- Cluster-8309.31136 BP_3 43.05 0.75 3052 91077436 XP_966791.1 2251 1.9e-250 PREDICTED: WD repeat-containing protein 36 [Tribolium castaneum]>gi|270001624|gb|EEZ98071.1| hypothetical protein TcasGA2_TC000478 [Tribolium castaneum] -- -- -- -- -- K14554 UTP21, WDR36 U3 small nucleolar RNA-associated protein 21 http://www.genome.jp/dbget-bin/www_bget?ko:K14554 Q8NI36 1315 2.7e-143 WD repeat-containing protein 36 OS=Homo sapiens GN=WDR36 PE=1 SV=1 PF04192//PF00400//PF00355 Utp21 specific WD40 associated putative domain//WD domain, G-beta repeat//Rieske [2Fe-2S] domain GO:0055114//GO:0006364 oxidation-reduction process//rRNA processing GO:0016491//GO:0005515//GO:0051537 oxidoreductase activity//protein binding//2 iron, 2 sulfur cluster binding GO:0032040 small-subunit processome KOG1539 WD repeat protein Cluster-8309.31137 BP_3 205.67 3.05 3546 642936430 XP_008198431.1 1069 2.5e-113 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X3 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.17492e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 447 1.4e-42 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31139 BP_3 91.00 1.45 3309 189240813 XP_001811587.1 1811 2.2e-199 PREDICTED: 4-aminobutyrate aminotransferase, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 P61922 1303 7.2e-142 4-aminobutyrate aminotransferase, mitochondrial OS=Mus musculus GN=Abat PE=1 SV=1 PF01335//PF00202//PF00155 Death effector domain//Aminotransferase class-III//Aminotransferase class I and II GO:0009058//GO:0042981 biosynthetic process//regulation of apoptotic process GO:0005515//GO:0008483//GO:0030170 protein binding//transaminase activity//pyridoxal phosphate binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.3114 BP_3 2.00 0.48 494 803217189 XP_011968949.1 768 2.8e-79 PREDICTED: 40S ribosomal protein S23 isoform X2 [Ovis aries musimon] 426349371 XM_004042233.1 494 0 PREDICTED: Gorilla gorilla gorilla ribosomal protein S23 (RPS23), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 P62298 745 5.4e-78 40S ribosomal protein S23 OS=Chinchilla lanigera GN=RPS23 PE=2 SV=1 PF00164 Ribosomal protein S12/S23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1749 40S ribosomal protein S23 Cluster-8309.31140 BP_3 507.93 3.02 8409 91085437 XP_968834.1 1867 1.8e-205 PREDICTED: protein zyg-11 homolog [Tribolium castaneum]>gi|270009168|gb|EFA05616.1| hypothetical protein TcasGA2_TC015823 [Tribolium castaneum] 462389525 APGK01019132.1 136 9.58924e-62 Dendroctonus ponderosae Seq01019142, whole genome shotgun sequence K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q3UFS0 750 2.4e-77 Protein zyg-11 homolog B OS=Mus musculus GN=Zyg11b PE=2 SV=2 PF13855//PF00073//PF02985//PF08711 Leucine rich repeat//picornavirus capsid protein//HEAT repeat//TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677//GO:0005515//GO:0005198 DNA binding//protein binding//structural molecule activity GO:0005634//GO:0019028 nucleus//viral capsid KOG3665 ZYG-1-like serine/threonine protein kinases Cluster-8309.31143 BP_3 376.00 6.54 3061 270016487 EFA12933.1 2989 0.0e+00 hypothetical protein TcasGA2_TC010479 [Tribolium castaneum] 551663104 XM_005834260.1 42 6.22485e-10 Guillardia theta CCMP2712 hypothetical protein (GUITHDRAFT_157624) mRNA, complete cds K01895 ACSS, acs acetyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01895 Q9VP61 2713 2.1e-305 Acetyl-coenzyme A synthetase OS=Drosophila melanogaster GN=AcCoAS PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.31144 BP_3 565.89 3.61 7840 642930792 XP_008196093.1 1558 1.1e-169 PREDICTED: ski oncogene [Tribolium castaneum] 759170310 XM_011377342.1 126 3.23732e-56 PREDICTED: Pteropus vampyrus SKI proto-oncogene (SKI), partial mRNA -- -- -- -- P49140 698 2.4e-71 Ski oncogene OS=Gallus gallus GN=SKI PE=1 SV=1 PF11365//PF08782 Protein of unknown function (DUF3166)//c-SKI Smad4 binding domain GO:0010506 regulation of autophagy GO:0046332 SMAD binding GO:0005615 extracellular space -- -- Cluster-8309.31145 BP_3 637.00 24.86 1527 546676940 ERL87864.1 798 2.9e-82 hypothetical protein D910_05252 [Dendroctonus ponderosae] -- -- -- -- -- K08509 SNAP29 synaptosomal-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K08509 Q9ERB0 266 5.8e-22 Synaptosomal-associated protein 29 OS=Mus musculus GN=Snap29 PE=2 SV=1 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.31146 BP_3 22.96 0.41 2967 91081621 XP_966892.1 951 1.0e-99 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P31684 456 1.1e-43 4-coumarate--CoA ligase 1 OS=Solanum tuberosum GN=4CL1 PE=3 SV=1 PF00501//PF03144 AMP-binding enzyme//Elongation factor Tu domain 2 GO:0008152 metabolic process GO:0005525//GO:0003824 GTP binding//catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.31148 BP_3 417.89 30.83 945 91083623 XP_970124.1 998 1.2e-105 PREDICTED: probable citrate synthase 2, mitochondrial [Tribolium castaneum]>gi|270006831|gb|EFA03279.1| hypothetical protein TcasGA2_TC013214 [Tribolium castaneum] -- -- -- -- -- K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q16P20 888 2.7e-94 Probable citrate synthase 2, mitochondrial OS=Aedes aegypti GN=AAEL011789 PE=3 SV=1 PF00285 Citrate synthase GO:0006099//GO:0044262//GO:0046487 tricarboxylic acid cycle//cellular carbohydrate metabolic process//glyoxylate metabolic process GO:0046912//GO:0004108 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer//citrate (Si)-synthase activity -- -- KOG2617 Citrate synthase Cluster-8309.31149 BP_3 898.62 6.37 7093 478254018 ENN74310.1 6609 0.0e+00 hypothetical protein YQE_09281, partial [Dendroctonus ponderosae] 242005974 XM_002423790.1 223 3.50332e-110 Pediculus humanus corporis jumonji/arid domain-containing protein, putative, mRNA K11446 KDM5, JARID1 histone demethylase JARID1 http://www.genome.jp/dbget-bin/www_bget?ko:K11446 Q9VMJ7 3573 0.0e+00 Lysine-specific demethylase lid OS=Drosophila melanogaster GN=lid PE=1 SV=1 PF08429//PF01388//PF00628 PLU-1-like protein//ARID/BRIGHT DNA binding domain//PHD-finger GO:0055114 oxidation-reduction process GO:0003677//GO:0016706//GO:0005515 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.3115 BP_3 2.00 3.77 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31151 BP_3 181.57 2.13 4403 91093481 XP_968172.1 1641 1.5e-179 PREDICTED: WD repeat domain phosphoinositide-interacting protein 3 [Tribolium castaneum]>gi|270012665|gb|EFA09113.1| hypothetical protein TcasGA2_TC015973 [Tribolium castaneum] 766932181 XM_011500000.1 121 1.09076e-53 PREDICTED: Ceratosolen solmsi marchali WD repeat domain phosphoinositide-interacting protein 3 (LOC105362539), mRNA -- -- -- -- Q9CR39 1375 4.3e-150 WD repeat domain phosphoinositide-interacting protein 3 OS=Mus musculus GN=Wdr45b PE=2 SV=2 PF04584//PF00240//PF03178//PF14560//PF00400 Poxvirus A28 family//Ubiquitin family//CPSF A subunit region//Ubiquitin-like domain//WD domain, G-beta repeat GO:0016032 viral process GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0019031//GO:0005634 viral envelope//nucleus KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.31152 BP_3 697.00 43.67 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31155 BP_3 31.00 15.37 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31159 BP_3 39.00 3.23 874 91087735 XP_974721.1 500 6.0e-48 PREDICTED: synaptosomal-associated protein 25 isoform X3 [Tribolium castaneum] 642930445 XM_969628.2 155 2.63998e-73 PREDICTED: Tribolium castaneum synaptosomal-associated protein 25 (LOC663588), transcript variant X3, mRNA K18211 SNAP25 synaptosomal-associated protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K18211 P36975 377 4.5e-35 Synaptosomal-associated protein 25 OS=Drosophila melanogaster GN=Snap25 PE=2 SV=1 PF02321//PF05739 Outer membrane efflux protein//SNARE domain GO:0006810 transport GO:0005515//GO:0005215 protein binding//transporter activity -- -- KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.31161 BP_3 475.85 3.49 6867 91077500 XP_969314.1 3473 0.0e+00 PREDICTED: exocyst complex component 1 [Tribolium castaneum]>gi|270002145|gb|EEZ98592.1| hypothetical protein TcasGA2_TC001107 [Tribolium castaneum] 805812953 XM_012292417.1 89 1.04841e-35 PREDICTED: Megachile rotundata exocyst complex component 1 (LOC100878684), transcript variant X4, mRNA -- -- -- -- Q9VVG4 2093 3.7e-233 Exocyst complex component 1 OS=Drosophila melanogaster GN=sec3 PE=1 SV=2 PF00588//PF07544 SpoU rRNA Methylase family//RNA polymerase II transcription mediator complex subunit 9 GO:0009451//GO:0006357//GO:0006396 RNA modification//regulation of transcription from RNA polymerase II promoter//RNA processing GO:0001104//GO:0003723//GO:0008173 RNA polymerase II transcription cofactor activity//RNA binding//RNA methyltransferase activity GO:0016592 mediator complex KOG2148 Exocyst protein Sec3 Cluster-8309.31162 BP_3 35.19 0.91 2155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31163 BP_3 1444.05 9.92 7305 270008334 EFA04782.1 2089 2.8e-231 hypothetical protein TcasGA2_TC030779 [Tribolium castaneum] -- -- -- -- -- K10630 RBCK1, HOIL1 RanBP-type and C3HC4-type zinc finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10630 E6ZIJ1 896 2.5e-94 RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Dicentrarchus labrax GN=rbck1 PE=3 SV=1 PF13639//PF09174//PF00641//PF14634//PF00240//PF00097 Ring finger domain//Maf1 regulator//Zn-finger in Ran binding protein and others//zinc-RING finger domain//Ubiquitin family//Zinc finger, C3HC4 type (RING finger) GO:0016480 negative regulation of transcription from RNA polymerase III promoter GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.31164 BP_3 457.79 9.78 2547 91085733 XP_973505.1 2855 0.0e+00 PREDICTED: tRNA (cytosine(34)-C(5))-methyltransferase [Tribolium castaneum] -- -- -- -- -- K15335 NSUN2 tRNA (cytosine34-C5)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15335 Q9W4M9 1723 1.1e-190 tRNA (cytosine(34)-C(5))-methyltransferase OS=Drosophila melanogaster GN=Nsun2 PE=2 SV=1 PF01728//PF01189 FtsJ-like methyltransferase//16S rRNA methyltransferase RsmF GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2198 tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily Cluster-8309.31165 BP_3 205.55 18.93 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31168 BP_3 111.00 5.76 1221 332374600 AEE62441.1 441 5.8e-41 unknown [Dendroctonus ponderosae]>gi|478260324|gb|ENN80075.1| hypothetical protein YQE_03491, partial [Dendroctonus ponderosae] 723569508 XM_010306612.1 99 5.0292e-42 PREDICTED: Balearica regulorum gibbericeps protein mab-21-like 2 (LOC104638742), mRNA -- -- -- -- Q5TW90 402 7.9e-38 Protein mab-21 OS=Anopheles gambiae GN=mab-21 PE=3 SV=3 PF08476 Viral D10 N-terminal -- -- GO:0016791 phosphatase activity -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.31170 BP_3 763.00 46.71 1079 91079744 XP_970506.1 444 2.3e-41 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 170043821 XM_001849518.1 105 2.04779e-45 Culex quinquefasciatus acyl-coa dehydrogenase, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 404 4.1e-38 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF00441 Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.31175 BP_3 348.00 33.53 792 -- -- -- -- -- 642938586 XM_008201631.1 46 9.32733e-13 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31176 BP_3 270.75 6.77 2218 642938587 XP_008199853.1 2711 6.3e-304 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X2 [Tribolium castaneum] 642938586 XM_008201631.1 732 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X6, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 Q16720 1836 7.5e-204 Plasma membrane calcium-transporting ATPase 3 OS=Homo sapiens GN=ATP2B3 PE=1 SV=3 PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0005388 calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum KOG0204 Calcium transporting ATPase Cluster-8309.31180 BP_3 95.25 1.44 3480 642938000 XP_008199165.1 535 2.1e-51 PREDICTED: uncharacterized protein LOC103314560 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 197 1.3e-13 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31181 BP_3 556.48 13.25 2316 642938000 XP_008199165.1 624 6.6e-62 PREDICTED: uncharacterized protein LOC103314560 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 197 8.9e-14 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31183 BP_3 515.77 3.03 8506 270012222 EFA08670.1 2246 2.0e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTX9 413 2.9e-38 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF06974//PF03376//PF00083//PF01277//PF04661//PF07690//PF03007 Protein of unknown function (DUF1298)//Adenovirus E3B protein//Sugar (and other) transporter//Oleosin//Poxvirus I3 ssDNA-binding protein//Major Facilitator Superfamily//Wax ester synthase-like Acyl-CoA acyltransferase domain GO:0045017//GO:0055085//GO:0042967//GO:0046486 glycerolipid biosynthetic process//transmembrane transport//acyl-carrier-protein biosynthetic process//glycerolipid metabolic process GO:0003697//GO:0022857//GO:0004144 single-stranded DNA binding//transmembrane transporter activity//diacylglycerol O-acyltransferase activity GO:0016021//GO:0012511//GO:0016020 integral component of membrane//monolayer-surrounded lipid storage body//membrane KOG2504 Monocarboxylate transporter Cluster-8309.31185 BP_3 114.71 1.56 3843 642937984 XP_008199157.1 261 1.4e-19 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 178 2.4e-11 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 PF08294//PF07535//PF00957 TIM21//DBF zinc finger//Synaptobrevin GO:0030150//GO:0016192 protein import into mitochondrial matrix//vesicle-mediated transport GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0016021//GO:0005744 integral component of membrane//mitochondrial inner membrane presequence translocase complex KOG1362 Choline transporter-like protein Cluster-8309.31187 BP_3 419.11 13.03 1842 91087867 XP_969419.1 2113 1.2e-234 PREDICTED: histone deacetylase 3 [Tribolium castaneum]>gi|270012009|gb|EFA08457.1| hypothetical protein TcasGA2_TC006104 [Tribolium castaneum] 195568433 XM_002102185.1 244 1.90246e-122 Drosophila simulans GD19615 (Dsim\GD19615), mRNA K11404 HDAC3 histone deacetylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11404 Q28DV3 1671 8.5e-185 Histone deacetylase 3 OS=Xenopus tropicalis GN=hdac3 PE=2 SV=1 -- -- GO:0070933//GO:0070932//GO:0006807//GO:0006355 histone H4 deacetylation//histone H3 deacetylation//nitrogen compound metabolic process//regulation of transcription, DNA-templated GO:0032041//GO:0046970//GO:0046969//GO:0097372 NAD-dependent histone deacetylase activity (H3-K14 specific)//NAD-dependent histone deacetylase activity (H4-K16 specific)//NAD-dependent histone deacetylase activity (H3-K9 specific)//NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0005634//GO:0000118 nucleus//histone deacetylase complex KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.31189 BP_3 71.72 4.26 1103 642915807 XP_008200086.1 1563 4.1e-171 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 766926462 XM_011496875.1 210 8.95299e-104 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- Q8CGF6 945 7.8e-101 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.31191 BP_3 311.57 2.52 6240 642923135 XP_008193624.1 2610 9.2e-292 PREDICTED: nuclear receptor coactivator 2 isoform X3 [Tribolium castaneum] 642923146 XM_008195408.1 389 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.2e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- -- -- Cluster-8309.31192 BP_3 182.42 3.13 3102 642910837 XP_971522.2 2676 1.0e-299 PREDICTED: probable DNA mismatch repair protein Msh6 [Tribolium castaneum] -- -- -- -- -- K08737 MSH6 DNA mismatch repair protein MSH6 http://www.genome.jp/dbget-bin/www_bget?ko:K08737 Q9VUM0 1766 1.4e-195 Probable DNA mismatch repair protein Msh6 OS=Drosophila melanogaster GN=Msh6 PE=1 SV=2 PF00995//PF00488//PF05188//PF05190//PF05192//PF01624 Sec1 family//MutS domain V//MutS domain II//MutS family domain IV//MutS domain III//MutS domain I GO:0006298//GO:0006904//GO:0016192 mismatch repair//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- KOG0217 Mismatch repair ATPase MSH6 (MutS family) Cluster-8309.31193 BP_3 1860.96 34.43 2897 264667471 ACY71321.1 794 1.6e-81 ribosomal biogenesis protein RLP24 [Chrysomela tremula] -- -- -- -- -- K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q9VGN9 595 7.8e-60 Probable ribosome biogenesis protein RLP24 OS=Drosophila melanogaster GN=RpL24-like PE=1 SV=1 PF06177//PF06305//PF02535 QueT transporter//Protein of unknown function (DUF1049)//ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0005887//GO:0005886//GO:0016020 integral component of plasma membrane//plasma membrane//membrane KOG1723 60s ribosomal protein L30 isolog Cluster-8309.31194 BP_3 60.59 0.57 5393 91078510 XP_969463.1 2698 4.9e-302 PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|642915541|ref|XP_008190658.1| PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|270003849|gb|EFA00297.1| hypothetical protein TcasGA2_TC003130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82094 626 3.7e-63 TATA element modulatory factor OS=Homo sapiens GN=TMF1 PE=1 SV=2 PF07926//PF02185//PF04871//PF00769//PF03376 TPR/MLP1/MLP2-like protein//Hr1 repeat//Uso1 / p115 like vesicle tethering protein, C terminal region//Ezrin/radixin/moesin family//Adenovirus E3B protein GO:0006606//GO:0015031//GO:0007165//GO:0006886 protein import into nucleus//protein transport//signal transduction//intracellular protein transport GO:0008565//GO:0008092 protein transporter activity//cytoskeletal protein binding GO:0016020//GO:0005737//GO:0019898 membrane//cytoplasm//extrinsic component of membrane KOG4673 Transcription factor TMF, TATA element modulatory factor Cluster-8309.31195 BP_3 422.34 4.03 5344 91078510 XP_969463.1 3397 0.0e+00 PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|642915541|ref|XP_008190658.1| PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|270003849|gb|EFA00297.1| hypothetical protein TcasGA2_TC003130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82094 856 7.9e-90 TATA element modulatory factor OS=Homo sapiens GN=TMF1 PE=1 SV=2 PF03376 Adenovirus E3B protein -- -- -- -- GO:0016020 membrane KOG4673 Transcription factor TMF, TATA element modulatory factor Cluster-8309.31197 BP_3 2.00 0.35 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31198 BP_3 1839.00 198.17 739 332377007 AEE63643.1 578 4.6e-57 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] 61651649 AB207213.1 74 2.36136e-28 Gastrophysa atrocyanea hsp 21 mRNA for small heat shock protein 21, complete cds K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 250 2.0e-20 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0006413//GO:0006446//GO:0007423 translational initiation//regulation of translational initiation//sensory organ development GO:0003743//GO:0005212 translation initiation factor activity//structural constituent of eye lens GO:0005840 ribosome -- -- Cluster-8309.312 BP_3 1.00 0.93 336 119623977 EAX03572.1 316 4.9e-27 tenascin XB, isoform CRA_a [Homo sapiens] 46358450 AC148664.1 302 1.82832e-155 Macaca mulatta Major Histocompatibility Complex BAC MMU021E24, complete sequence K06252 TN tenascin http://www.genome.jp/dbget-bin/www_bget?ko:K06252 P22105 316 2.0e-28 Tenascin-X OS=Homo sapiens GN=TNXB PE=1 SV=4 PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.3120 BP_3 4.00 1.31 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31200 BP_3 36.28 0.52 3644 741829513 AJA91072.1 1393 7.0e-151 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 937 2.2e-99 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0055114//GO:0051249//GO:0006955 oxidation-reduction process//regulation of lymphocyte activation//immune response GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.31202 BP_3 776.42 11.27 3611 642919917 XP_008192124.1 1147 2.3e-122 PREDICTED: transmembrane 7 superfamily member 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS93 526 9.8e-52 Transmembrane 7 superfamily member 3 OS=Homo sapiens GN=TM7SF3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31203 BP_3 440.94 14.25 1783 478251095 ENN71571.1 2088 8.8e-232 hypothetical protein YQE_11671, partial [Dendroctonus ponderosae]>gi|546683211|gb|ERL93051.1| hypothetical protein D910_10353 [Dendroctonus ponderosae] 795042442 XM_012011877.1 144 7.15473e-67 PREDICTED: Vollenhovia emeryi CXXC-type zinc finger protein 1-like (LOC105561680), transcript variant X2, mRNA K14960 CXXC1, SPP1, CPS40 COMPASS component SPP1 http://www.genome.jp/dbget-bin/www_bget?ko:K14960 Q9W352 1023 1.1e-109 CXXC-type zinc finger protein 1 OS=Drosophila melanogaster GN=Cfp1 PE=1 SV=1 PF00628//PF02008 PHD-finger//CXXC zinc finger domain -- -- GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding -- -- KOG1632 Uncharacterized PHD Zn-finger protein Cluster-8309.31204 BP_3 232.80 3.57 3435 91081375 XP_972116.1 4324 0.0e+00 PREDICTED: chromatin-remodeling complex ATPase chain Iswi [Tribolium castaneum]>gi|270005181|gb|EFA01629.1| hypothetical protein TcasGA2_TC007199 [Tribolium castaneum] 815799995 XR_001100589.1 645 0 PREDICTED: Linepithema humile chromatin-remodeling complex ATPase chain Iswi (LOC105671246), transcript variant X2, misc_RNA K11654 SMARCA5, SNF2H, ISWI SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11654 Q24368 3747 0.0e+00 Chromatin-remodeling complex ATPase chain Iswi OS=Drosophila melanogaster GN=Iswi PE=1 SV=1 PF09111//PF04851//PF05416//PF06422//PF00176//PF09110//PF13892//PF00270 SLIDE//Type III restriction enzyme, res subunit//Southampton virus-type processing peptidase//CDR ABC transporter//SNF2 family N-terminal domain//HAND//DNA-binding domain//DEAD/DEAH box helicase GO:0006508//GO:0043044//GO:0006810//GO:0006338 proteolysis//ATP-dependent chromatin remodeling//transport//chromatin remodeling GO:0003676//GO:0004197//GO:0003677//GO:0004386//GO:0031491//GO:0042626//GO:0016818//GO:0016787//GO:0005524 nucleic acid binding//cysteine-type endopeptidase activity//DNA binding//helicase activity//nucleosome binding//ATPase activity, coupled to transmembrane movement of substances//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//hydrolase activity//ATP binding GO:0000785//GO:0005634//GO:0016021//GO:0016585 chromatin//nucleus//integral component of membrane//obsolete chromatin remodeling complex KOG0385 Chromatin remodeling complex WSTF-ISWI, small subunit Cluster-8309.31206 BP_3 1959.47 37.86 2786 189235208 XP_001808961.1 811 1.6e-83 PREDICTED: BTB/POZ domain-containing protein 2 [Tribolium castaneum]>gi|270003755|gb|EFA00203.1| hypothetical protein TcasGA2_TC003028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TZE1 140 4.3e-07 BTB/POZ domain-containing protein 6-B OS=Danio rerio GN=btbd6b PE=2 SV=1 PF15171 Neuropeptide secretory protein family, NPQ, spexin GO:0007218 neuropeptide signaling pathway GO:0005184 neuropeptide hormone activity -- -- -- -- Cluster-8309.31208 BP_3 14.63 4.44 450 642925507 XP_008194579.1 268 2.5e-21 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane -- -- Cluster-8309.31209 BP_3 342.02 11.66 1706 642923918 XP_969405.2 1124 5.1e-120 PREDICTED: serine/threonine-protein phosphatase 2A activator [Tribolium castaneum] 318037409 NM_001201142.1 54 7.34096e-17 Ictalurus punctatus serine/threonine-protein phosphatase 2a regulatory subunit b' (ptpa), mRNA >gnl|BL_ORD_ID|9527029 Ictalurus punctatus clone CBPN47522 serine/threonine-protein phosphatase 2a regulatory subunit b' (PTPA) mRNA, complete cds K17605 PPP2R4, PTPA serine/threonine-protein phosphatase 2A activator http://www.genome.jp/dbget-bin/www_bget?ko:K17605 Q2KJ44 899 2.6e-95 Serine/threonine-protein phosphatase 2A activator OS=Bos taurus GN=PPP2R4 PE=2 SV=1 PF03095 Phosphotyrosyl phosphate activator (PTPA) protein -- -- GO:0019211 phosphatase activator activity -- -- KOG2867 Phosphotyrosyl phosphatase activator Cluster-8309.3121 BP_3 6.11 0.33 1175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31210 BP_3 195.75 5.74 1935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31212 BP_3 114.01 1.25 4677 478255334 ENN75560.1 246 9.1e-18 hypothetical protein YQE_07903, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.31213 BP_3 8.03 0.67 865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03069 Acetamidase/Formamidase family GO:0006807 nitrogen compound metabolic process GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides -- -- -- -- Cluster-8309.31214 BP_3 30.46 0.86 1998 642920914 XP_008192613.1 174 8.6e-10 PREDICTED: outer dense fiber protein 3-B isoform X2 [Tribolium castaneum]>gi|270006132|gb|EFA02580.1| hypothetical protein TcasGA2_TC008298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31216 BP_3 14.33 0.47 1763 91086851 XP_974311.1 638 1.2e-63 PREDICTED: vacuolar protein-sorting-associated protein 25 [Tribolium castaneum]>gi|270010461|gb|EFA06909.1| hypothetical protein TcasGA2_TC009858 [Tribolium castaneum] -- -- -- -- -- K12189 VPS25, EAP20 ESCRT-II complex subunit VPS25 http://www.genome.jp/dbget-bin/www_bget?ko:K12189 Q6NWF4 431 5.0e-41 Vacuolar protein-sorting-associated protein 25 OS=Danio rerio GN=vps25 PE=2 SV=2 PF07749 Endoplasmic reticulum protein ERp29, C-terminal domain -- -- -- -- GO:0005783 endoplasmic reticulum KOG4068 Uncharacterized conserved protein Cluster-8309.31217 BP_3 454.00 6.26 3786 270009782 EFA06230.1 221 5.8e-15 hypothetical protein TcasGA2_TC009079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.31220 BP_3 47.63 5.68 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31223 BP_3 44.36 0.72 3280 157126475 XP_001660898.1 773 4.9e-79 AAEL010538-PA [Aedes aegypti]>gi|108873249|gb|EAT37474.1| AAEL010538-PA [Aedes aegypti] -- -- -- -- -- K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q9VU70 394 1.8e-36 Tetratricopeptide repeat protein 36 homolog OS=Drosophila melanogaster GN=CG14105 PE=1 SV=1 PF03169//PF05132//PF13181//PF03839//PF13414//PF13371//PF00515//PF13374 OPT oligopeptide transporter protein//RNA polymerase III RPC4//Tetratricopeptide repeat//Translocation protein Sec62//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006144//GO:0055085//GO:0006383//GO:0006351//GO:0015031//GO:0006206 purine nucleobase metabolic process//transmembrane transport//transcription from RNA polymerase III promoter//transcription, DNA-templated//protein transport//pyrimidine nucleobase metabolic process GO:0005515//GO:0003677//GO:0003899//GO:0008565 protein binding//DNA binding//DNA-directed RNA polymerase activity//protein transporter activity GO:0016021//GO:0005730//GO:0005666 integral component of membrane//nucleolus//DNA-directed RNA polymerase III complex KOG2927 Membrane component of ER protein translocation complex Cluster-8309.31226 BP_3 5.00 1.29 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31228 BP_3 272.00 13.93 1233 189235480 XP_967613.2 643 2.2e-64 PREDICTED: nucleolar protein 16 [Tribolium castaneum]>gi|270003065|gb|EEZ99512.1| hypothetical protein TcasGA2_TC000093 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CPT5 297 1.2e-25 Nucleolar protein 16 OS=Mus musculus GN=Nop16 PE=2 SV=1 PF10176 Protein of unknown function (DUF2370) GO:0030001//GO:0007034 metal ion transport//vacuolar transport -- -- -- -- KOG4706 Uncharacterized conserved protein Cluster-8309.31229 BP_3 71.00 2.11 1914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.31230 BP_3 179.92 2.16 4301 642931657 XP_008196674.1 2456 4.5e-274 PREDICTED: rap1 GTPase-activating protein 1 isoform X3 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.40759e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 3.8e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF13851//PF07836//PF02145//PF02188 Growth-arrest specific micro-tubule binding//DmpG-like communication domain//Rap/ran-GAP//GoLoco motif GO:0048870//GO:0051056//GO:0019439 cell motility//regulation of small GTPase mediated signal transduction//aromatic compound catabolic process GO:0016833//GO:0005096//GO:0030695 oxo-acid-lyase activity//GTPase activator activity//GTPase regulator activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.31231 BP_3 46.08 1.00 2514 91088273 XP_967838.1 497 3.8e-47 PREDICTED: protein scylla [Tribolium castaneum]>gi|270012158|gb|EFA08606.1| hypothetical protein TcasGA2_TC006266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTH4 254 2.4e-20 Protein scylla OS=Drosophila melanogaster GN=scyl PE=2 SV=1 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.31232 BP_3 295.12 12.55 1425 642922280 XP_008193091.1 142 3.2e-06 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31233 BP_3 178.88 5.04 2004 642922278 XP_008193090.1 283 2.0e-22 PREDICTED: UPF0544 protein C5orf45 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32PP1 197 7.7e-14 UPF0544 protein C5orf45 homolog OS=Danio rerio GN=zgc:123335 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31234 BP_3 90.58 0.61 7468 642915750 XP_008190789.1 4116 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 768311758 CP010986.1 610 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 2.0e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.31235 BP_3 374.26 7.19 2802 546676927 ERL87851.1 1793 2.2e-197 hypothetical protein D910_05239 [Dendroctonus ponderosae] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 728 2.9e-75 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.31237 BP_3 1774.21 42.29 2314 91090858 XP_967143.1 1222 3.0e-131 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 912 1.1e-96 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- KOG0819 Annexin Cluster-8309.31238 BP_3 25.00 8.15 439 4506605 NP_000969.1 610 5.3e-61 60S ribosomal protein L23 [Homo sapiens]>gi|12584986|ref|NP_075029.1| 60S ribosomal protein L23 [Mus musculus]>gi|56090279|ref|NP_001007600.1| 60S ribosomal protein L23 [Rattus norvegicus]>gi|58332166|ref|NP_001011231.1| 60S ribosomal protein L23 [Xenopus (Silurana) tropicalis]>gi|194018720|ref|NP_001123427.1| 60S ribosomal protein L23 [Sus scrofa]>gi|318760126|ref|NP_001187049.1| 60S ribosomal protein L23 [Ictalurus punctatus]>gi|388490440|ref|NP_001253138.1| 60S ribosomal protein L23 [Macaca mulatta]>gi|756140997|ref|NP_001291852.1| ribosomal protein L23 [Ailuropoda melanoleuca]>gi|114667757|ref|XP_511444.2| PREDICTED: 60S ribosomal protein L23 [Pan troglodytes]>gi|126308182|ref|XP_001366590.1| PREDICTED: 60S ribosomal protein L23 [Monodelphis domestica]>gi|296202685|ref|XP_002748553.1| PREDICTED: 60S ribosomal protein L23 [Callithrix jacchus]>gi|327275650|ref|XP_003222586.1| PREDICTED: 60S ribosomal protein L23 [Anolis carolinensis]>gi|332258346|ref|XP_003278259.1| PREDICTED: 60S ribosomal protein L23 [Nomascus leucogenys]>gi|332258358|ref|XP_003278265.1| PREDICTED: 60S ribosomal protein L23 [Nomascus leucogenys]>gi|338710897|ref|XP_003362441.1| PREDICTED: 60S ribosomal protein L23 [Equus caballus]>gi|344285963|ref|XP_003414729.1| PREDICTED: 60S ribosomal protein L23 [Loxodonta africana]>gi|345319092|ref|XP_001509789.2| PREDICTED: 60S ribosomal protein L23 [Ornithorhynchus anatinus]>gi|348517843|ref|XP_003446442.1| PREDICTED: 60S ribosomal protein L23-like [Oreochromis niloticus]>gi|348562313|ref|XP_003466955.1| PREDICTED: 60S ribosomal protein L23 [Cavia porcellus]>gi|354474813|ref|XP_003499624.1| PREDICTED: 60S ribosomal protein L23 [Cricetulus griseus]>gi|363743473|ref|XP_418122.3| PREDICTED: 60S ribosomal protein L23 isoformX2 [Gallus gallus]>gi|377837128|ref|XP_003688806.1| PREDICTED: 60S ribosomal protein L23 [Mus musculus]>gi|377837258|ref|XP_003689266.1| PREDICTED: 60S ribosomal protein L23 isoform X2 [Mus musculus]>gi|395532530|ref|XP_003768323.1| PREDICTED: 60S ribosomal protein L23 [Sarcophilus harrisii]>gi|395826550|ref|XP_003786480.1| PREDICTED: 60S ribosomal protein L23 [Otolemur garnettii]>gi|397477028|ref|XP_003809888.1| PREDICTED: 60S ribosomal protein L23 [Pan paniscus]>gi|402855371|ref|XP_003892299.1| PREDICTED: 60S ribosomal protein L23 [Papio anubis]>gi|402899985|ref|XP_003912963.1| PREDICTED: 60S ribosomal protein L23 [Papio anubis]>gi|410980905|ref|XP_003996814.1| PREDICTED: 60S ribosomal protein L23 [Felis catus]>gi|426348537|ref|XP_004041890.1| PREDICTED: 60S ribosomal protein L23 [Gorilla gorilla gorilla]>gi|432960814|ref|XP_004086478.1| PREDICTED: 60S ribosomal protein L23 [Oryzias latipes]>gi|471380551|ref|XP_004378071.1| PREDICTED: 60S ribosomal protein L23 [Trichechus manatus latirostris]>gi|472350883|ref|XP_004395126.1| PREDICTED: 60S ribosomal protein L23 [Odobenus rosmarus divergens]>gi|478520865|ref|XP_004434646.1| PREDICTED: 60S ribosomal protein L23 [Ceratotherium simum simum]>gi|488526322|ref|XP_004454995.1| PREDICTED: 60S ribosomal protein L23 [Dasypus novemcinctus]>gi|499035979|ref|XP_004568658.1| PREDICTED: 60S ribosomal protein L23 [Maylandia zebra]>gi|504159898|ref|XP_004591186.1| PREDICTED: 60S ribosomal protein L23 [Ochotona princeps]>gi|505802875|ref|XP_004608777.1| PREDICTED: 60S ribosomal protein L23 [Sorex araneus]>gi|507543109|ref|XP_004655546.1| PREDICTED: 60S ribosomal protein L23 [Jaculus jaculus]>gi|507664755|ref|XP_004707161.1| PREDICTED: 60S ribosomal protein L23 [Echinops telfairi]>gi|507952684|ref|XP_004684321.1| PREDICTED: 60S ribosomal protein L23 [Condylura cristata]>gi|511890070|ref|XP_004764745.1| PREDICTED: 60S ribosomal protein L23 [Mustela putorius furo]>gi|512995994|ref|XP_004859587.1| PREDICTED: 60S ribosomal protein L23 [Heterocephalus glaber]>gi|524951944|ref|XP_005075973.1| PREDICTED: 60S ribosomal protein L23 [Mesocricetus auratus]>gi|527244975|ref|XP_005140830.1| PREDICTED: 60S ribosomal protein L23 [Melopsittacus undulatus]>gi|530624681|ref|XP_005301894.1| PREDICTED: 60S ribosomal protein L23 [Chrysemys picta bellii]>gi|532071999|ref|XP_005321819.1| PREDICTED: 60S ribosomal protein L23 [Ictidomys tridecemlineatus]>gi|533160995|ref|XP_005394345.1| PREDICTED: 60S ribosomal protein L23 [Chinchilla lanigera]>gi|543376513|ref|XP_005531465.1| PREDICTED: 60S ribosomal protein L23 [Pseudopodoces humilis]>gi|543734608|ref|XP_005508298.1| PREDICTED: 60S ribosomal protein L23 [Columba livia]>gi|548539238|ref|XP_005752845.1| PREDICTED: 60S ribosomal protein L23-like [Pundamilia nyererei]>gi|551531771|ref|XP_005817333.1| PREDICTED: 60S ribosomal protein L23-like [Xiphophorus maculatus]>gi|554880449|ref|XP_005950010.1| PREDICTED: 60S ribosomal protein L23-like [Haplochromis burtoni]>gi|555972075|ref|XP_005898045.1| PREDICTED: 60S ribosomal protein L23 [Bos mutus]>gi|556738430|ref|XP_005964788.1| PREDICTED: 60S ribosomal protein L23 [Pantholops hodgsonii]>gi|557279173|ref|XP_006022629.1| PREDICTED: 60S ribosomal protein L23 [Alligator sinensis]>gi|558215710|ref|XP_006108626.1| PREDICTED: 60S ribosomal protein L23-like [Myotis lucifugus]>gi|560900027|ref|XP_006176435.1| PREDICTED: 60S ribosomal protein L23 [Camelus ferus]>gi|560984157|ref|XP_006214292.1| PREDICTED: 60S ribosomal protein L23 [Vicugna pacos]>gi|562854662|ref|XP_006155929.1| PREDICTED: 60S ribosomal protein L23 [Tupaia chinensis]>gi|564236289|ref|XP_006275052.1| PREDICTED: 60S ribosomal protein L23 [Alligator mississippiensis]>gi|573901345|ref|XP_006638399.1| PREDICTED: 60S ribosomal protein L23-like [Lepisosteus oculatus]>gi|584023253|ref|XP_006806271.1| PREDICTED: 60S ribosomal protein L23-like [Neolamprologus brichardi]>gi|584059750|ref|XP_006774353.1| PREDICTED: 60S ribosomal protein L23 [Myotis davidii]>gi|585183569|ref|XP_006743370.1| PREDICTED: 60S ribosomal protein L23 [Leptonychotes weddellii]>gi|585671995|ref|XP_006889432.1| PREDICTED: 60S ribosomal protein L23 [Elephantulus edwardii]>gi|586448839|ref|XP_006832600.1| PREDICTED: 60S ribosomal protein L23 [Chrysochloris asiatica]>gi|586539893|ref|XP_006924783.1| PREDICTED: 60S ribosomal protein L23 [Pteropus alecto]>gi|589917216|ref|XP_006971922.1| PREDICTED: 60S ribosomal protein L23 [Peromyscus maniculatus bairdii]>gi|591319181|ref|XP_007085828.1| PREDICTED: 60S ribosomal protein L23 [Panthera tigris altaica]>gi|591374654|ref|XP_007062013.1| PREDICTED: 60S ribosomal protein L23 [Chelonia mydas]>gi|593734344|ref|XP_007112625.1| PREDICTED: 60S ribosomal protein L23 [Physeter catodon]>gi|594042833|ref|XP_006045943.1| PREDICTED: 60S ribosomal protein L23 [Bubalus bubalis]>gi|594658549|ref|XP_007177585.1| PREDICTED: 60S ribosomal protein L23 [Balaenoptera acutorostrata scammoni]>gi|602646944|ref|XP_007429902.1| PREDICTED: 60S ribosomal protein L23 [Python bivittatus]>gi|602709914|ref|XP_007465209.1| PREDICTED: 60S ribosomal protein L23 [Lipotes vexillifer]>gi|617471823|ref|XP_007575658.1| PREDICTED: 60S ribosomal protein L23 [Poecilia formosa]>gi|617524455|ref|XP_007544921.1| PREDICTED: 60S ribosomal protein L23 [Poecilia formosa]>gi|617637767|ref|XP_007530989.1| PREDICTED: 60S ribosomal protein L23 [Erinaceus europaeus]>gi|625248473|ref|XP_007615524.1| PREDICTED: 60S ribosomal protein L23 [Cricetulus griseus]>gi|634851396|ref|XP_007940203.1| PREDICTED: 60S ribosomal protein L23 [Orycteropus afer afer]>gi|640813814|ref|XP_008063617.1| PREDICTED: 60S ribosomal protein L23 [Tarsius syrichta]>gi|641724256|ref|XP_008152011.1| PREDICTED: 60S ribosomal protein L23 [Eptesicus fuscus]>gi|657596416|ref|XP_008302910.1| PREDICTED: 60S ribosomal protein L23 [Stegastes partitus]>gi|657803419|ref|XP_008328798.1| PREDICTED: 60S ribosomal protein L23 [Cynoglossus semilaevis]>gi|658861016|ref|XP_008413270.1| PREDICTED: 60S ribosomal protein L23 [Poecilia reticulata]>gi|664728631|ref|XP_008521501.1| PREDICTED: 60S ribosomal protein L23 [Equus przewalskii]>gi|670977783|ref|XP_008687238.1| PREDICTED: 60S ribosomal protein L23 [Ursus maritimus]>gi|674072617|ref|XP_008843500.1| PREDICTED: 60S ribosomal protein L23 [Nannospalax galili]>gi|699674330|ref|XP_009885393.1| PREDICTED: 60S ribosomal protein L23 [Charadrius vociferus]>gi|724903239|ref|XP_010377635.1| PREDICTED: 60S ribosomal protein L23 [Rhinopithecus roxellana]>gi|729725815|ref|XP_010583836.1| PREDICTED: 60S ribosomal protein L23 [Haliaeetus leucocephalus]>gi|734629155|ref|XP_010742852.1| PREDICTED: 60S ribosomal protein L23 [Larimichthys crocea]>gi|742135727|ref|XP_010840991.1| PREDICTED: 60S ribosomal protein L23 [Bison bison bison]>gi|742149732|ref|XP_010844046.1| PREDICTED: 60S ribosomal protein L23 [Bison bison bison]>gi|743729410|ref|XP_010958797.1| PREDICTED: 60S ribosomal protein L23 [Camelus bactrianus]>gi|744599820|ref|XP_010990145.1| PREDICTED: 60S ribosomal protein L23 [Camelus dromedarius]>gi|759190308|ref|XP_011382607.1| PREDICTED: 60S ribosomal protein L23 [Pteropus vampyrus]>gi|768393400|ref|XP_011592359.1| PREDICTED: 60S ribosomal protein L23 [Aquila chrysaetos canadensis]>gi|795158697|ref|XP_011840103.1| PREDICTED: 60S ribosomal protein L23 [Mandrillus leucophaeus]>gi|795295577|ref|XP_011815217.1| PREDICTED: 60S ribosomal protein L23 [Colobus angolensis palliatus]>gi|795295584|ref|XP_011815218.1| PREDICTED: 60S ribosomal protein L23 [Colobus angolensis palliatus]>gi|795526735|ref|XP_011901790.1| PREDICTED: 60S ribosomal protein L23 isoform X2 [Cercocebus atys]>gi|795582893|ref|XP_011723658.1| PREDICTED: 60S ribosomal protein L23 [Macaca nemestrina]>gi|803120744|ref|XP_012041406.1| PREDICTED: 60S ribosomal protein L23 [Ovis aries]>gi|803275253|ref|XP_011997302.1| PREDICTED: 60S ribosomal protein L23 [Ovis aries musimon]>gi|817274545|ref|XP_012307344.1| PREDICTED: 60S ribosomal protein L23 [Aotus nancymaae]>gi|826272564|ref|XP_012517968.1| PREDICTED: 60S ribosomal protein L23 [Propithecus coquereli]>gi|826293327|ref|XP_012499631.1| PREDICTED: 60S ribosomal protein L23 [Propithecus coquereli]>gi|829772259|ref|XP_012621394.1| PREDICTED: 60S ribosomal protein L23 [Microcebus murinus]>gi|852733226|ref|XP_012893563.1| PREDICTED: 60S ribosomal protein L23 [Dipodomys ordii]>gi|46577102|sp|Q90YU5.2|RL23_ICTPU RecName: Full=60S ribosomal protein L23 [Ictalurus punctatus]>gi|51338616|sp|P62831.1|RL23_PIG RecName: Full=60S ribosomal protein L23; AltName: Full=Ribosomal protein L17>gi|51338617|sp|P62832.1|RL23_RAT RecName: Full=60S ribosomal protein L23>gi|51338639|sp|P62829.1|RL23_HUMAN RecName: Full=60S ribosomal protein L23; AltName: Full=60S ribosomal protein L17>gi|51338640|sp|P62830.1|RL23_MOUSE RecName: Full=60S ribosomal protein L23>gi|190356062|sp|Q3T057.2|RL23_BOVIN RecName: Full=60S ribosomal protein L23>gi|187609309|pdb|2ZKR|KK Chain k, Structure Of A Mammalian Ribosomal 60s Subunit Within An 80s Complex Obtained By Docking Homology Models Of The Rna And Proteins Into An 8.7 A Cryo-em Map>gi|485601426|pdb|3J3B|V Chain V, Structure Of The Human 60s Ribosomal Proteins>gi|665764279|pdb|4CXD|V Chain V, Regulation Of The Mammalian Elongation Cycle By 40s Subunit Rolling: A Eukaryotic-specific Ribosome Rearrangement>gi|672884396|pdb|4UPX|V Chain V, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Pre-like State>gi|672884448|pdb|4UQ1|V Chain V, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Post-like State>gi|675970148|pdb|4W20|V Chain V, Structure Of The Mammalian 60s Ribosomal Subunit (this Entry Contains The Large Ribosomal Proteins)>gi|675970199|pdb|4W22|V Chain V, Structure Of The 80s Mammalian Ribosome Bound To Eef2 (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970290|pdb|4W25|V Chain V, Structure Of The Idle Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970343|pdb|4W27|V Chain V, Structure Of The Translating Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|5354205|gb|AAD42413.1|AF158022_1 ribosomal protein L23 [Mus musculus]>gi|9502282|gb|AAF88071.1|AF287271_1 ribosomal protein L23 [Mus musculus]>gi|24762286|gb|AAK95149.2|AF401577_1 ribosomal protein L23 [Ictalurus punctatus]>gi|34194|emb|CAA39417.1| HL23 ribosomal protein [Homo sapiens]>gi|36126|emb|CAA37023.1| ribosomal protein L17 [Homo sapiens]>gi|57688|emb|CAA41177.1| ribosomal protein L23 [Rattus rattus]>gi|12846298|dbj|BAB27112.1| unnamed protein product [Mus musculus]>gi|12858591|dbj|BAB31373.1| unnamed protein product [Mus musculus]>gi|14603313|gb|AAH10114.1| Ribosomal protein L23 [Homo sapiens]>gi|17932948|dbj|BAB79465.1| ribosomal protein L23 [Homo sapiens]>gi|19484155|gb|AAH25918.1| Ribosomal protein L23 [Mus musculus]>gi|37231757|gb|AAH58500.1| Ribosomal protein L23 [Rattus norvegicus]>gi|51980397|gb|AAH81448.1| Ribosomal protein L23 [Mus musculus]>gi|56611168|gb|AAH87796.1| ribosomal protein L23 [Xenopus (Silurana) tropicalis]>gi|74177908|dbj|BAE29753.1| unnamed protein product [Mus musculus]>gi|74207716|dbj|BAE40102.1| unnamed protein product [Mus musculus]>gi|74356227|gb|AAI04652.1| Ribosomal protein L23 [Homo sapiens]>gi|76780073|gb|AAI06062.1| RPL23 protein [Homo sapiens]>gi|89268196|emb|CAJ82654.1| ribosomal protein L23 [Xenopus (Silurana) tropicalis]>gi|117661026|gb|ABK55650.1| RPL23 [Sus scrofa]>gi|119580944|gb|EAW60540.1| ribosomal protein L23, isoform CRA_b [Homo sapiens]>gi|119580945|gb|EAW60541.1| ribosomal protein L23, isoform CRA_b [Homo sapiens]>gi|123993085|gb|ABM84144.1| ribosomal protein L23 [synthetic construct]>gi|124000075|gb|ABM87546.1| ribosomal protein L23 [synthetic construct]>gi|148684153|gb|EDL16100.1| ribosomal protein L23, isoform CRA_b [Mus musculus]>gi|149054067|gb|EDM05884.1| rCG34264, isoform CRA_b [Rattus norvegicus]>gi|151556408|gb|AAI48015.1| Ribosomal protein L23 [Bos taurus]>gi|164690981|dbj|BAF98673.1| ribosomal protein L23 [Solea senegalensis]>gi|206558008|gb|ACI12870.1| ribosomal protein L23 [Gillichthys mirabilis]>gi|261860426|dbj|BAI46735.1| ribosomal protein L23 [synthetic construct]>gi|296476465|tpg|DAA18580.1| TPA: 60S ribosomal protein L23 [Bos taurus]>gi|327239298|gb|AEA39516.1| ribosomal protein L23 [Ailuropoda melanoleuca]>gi|327239400|gb|AEA39567.1| ribosomal protein L23 [Ailuropoda melanoleuca]>gi|344249178|gb|EGW05282.1| 60S ribosomal protein L23 [Cricetulus griseus]>gi|351706759|gb|EHB09678.1| 60S ribosomal protein L23 [Heterocephalus glaber]>gi|444713983|gb|ELW54871.1| 60S ribosomal protein L23 [Tupaia chinensis]>gi|465974411|gb|EMP33812.1| 60S ribosomal protein L23 [Chelonia mydas]>gi|649105273|gb|AIC50337.1| RPL23, partial [synthetic construct]>gi|808848118|gb|KKF09104.1| 60S ribosomal protein L23 [Larimichthys crocea] 694833446 XM_009475846.1 159 7.62775e-76 PREDICTED: Nipponia nippon ribosomal protein L23 (RPL23), mRNA K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P62832 610 2.2e-62 60S ribosomal protein L23 OS=Rattus norvegicus GN=Rpl23 PE=2 SV=1 PF00238 Ribosomal protein L14p/L23e GO:0042254//GO:0006415//GO:0006413//GO:0000184//GO:0006412//GO:0006414//GO:0006614//GO:0006610//GO:0019083 ribosome biogenesis//translational termination//translational initiation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//translation//translational elongation//SRP-dependent cotranslational protein targeting to membrane//ribosomal protein import into nucleus//viral transcription GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005730//GO:0005840//GO:0022625 nucleolus//ribosome//cytosolic large ribosomal subunit KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.31239 BP_3 205.79 8.50 1459 443725752 ELU13203.1 1077 1.2e-114 hypothetical protein CAPTEDRAFT_149382 [Capitella teleta] -- -- -- -- -- K01805 xylA xylose isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01805 Q9FKK7 810 4.6e-85 Xylose isomerase OS=Arabidopsis thaliana GN=XYLA PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31244 BP_3 116.12 1.03 5702 642928449 XP_008193790.1 3616 0.0e+00 PREDICTED: transcriptional-regulating factor 1 isoform X2 [Tribolium castaneum] 642928448 XM_008195568.1 503 0 PREDICTED: Tribolium castaneum transcriptional-regulating factor 1 (LOC103313127), transcript variant X2, mRNA -- -- -- -- Q08DG8 213 3.1e-15 Zinc finger protein 135 OS=Bos taurus GN=ZNF135 PE=2 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.31245 BP_3 38.07 1.45 1556 -- -- -- -- -- 642928448 XM_008195568.1 132 2.91705e-60 PREDICTED: Tribolium castaneum transcriptional-regulating factor 1 (LOC103313127), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31246 BP_3 14.30 0.33 2391 91095137 XP_972151.1 803 1.2e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.01487e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.1e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.31247 BP_3 233.55 5.22 2447 91095137 XP_972151.1 803 1.2e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.06276e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.2e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.31250 BP_3 688.00 19.85 1962 642940045 XP_972775.2 1228 5.1e-132 PREDICTED: ankyrin repeat and MYND domain-containing protein 2 [Tribolium castaneum]>gi|270015900|gb|EFA12348.1| hypothetical protein TcasGA2_TC004088 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMD2 678 1.3e-69 Ankyrin repeat and MYND domain-containing protein 2 OS=Gallus gallus GN=ANKMY2 PE=2 SV=1 PF13597//PF13606//PF00023 Anaerobic ribonucleoside-triphosphate reductase//Ankyrin repeat//Ankyrin repeat GO:0055114//GO:0006206//GO:0006260 oxidation-reduction process//pyrimidine nucleobase metabolic process//DNA replication GO:0016491//GO:0005515//GO:0043169//GO:0008998 oxidoreductase activity//protein binding//cation binding//ribonucleoside-triphosphate reductase activity -- -- KOG1710 MYND Zn-finger and ankyrin repeat protein Cluster-8309.31254 BP_3 219.33 1.72 6449 91085823 XP_974821.1 3077 0.0e+00 PREDICTED: bone morphogenetic protein receptor type-2 [Tribolium castaneum]>gi|270011027|gb|EFA07475.1| wishful thinking [Tribolium castaneum] -- -- -- -- -- K04671 BMPR2 bone morphogenetic protein receptor type-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04671 O35607 801 2.3e-83 Bone morphogenetic protein receptor type-2 OS=Mus musculus GN=Bmpr2 PE=1 SV=1 PF03829//PF06221//PF07714//PF00069//PF01064//PF03460 PTS system glucitol/sorbitol-specific IIA component//Putative zinc finger motif, C2HC5-type//Protein tyrosine kinase//Protein kinase domain//Activin types I and II receptor domain//Nitrite/Sulfite reductase ferredoxin-like half domain GO:0016310//GO:0008643//GO:0023014//GO:0009069//GO:0006468//GO:0007178//GO:0055114//GO:0006355//GO:0009401 phosphorylation//carbohydrate transport//signal transduction by protein phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//oxidation-reduction process//regulation of transcription, DNA-templated//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0016491//GO:0004672//GO:0005024//GO:0008982//GO:0004675//GO:0004702//GO:0005524//GO:0008270 oxidoreductase activity//protein kinase activity//transforming growth factor beta-activated receptor activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//transmembrane receptor protein serine/threonine kinase activity//receptor signaling protein serine/threonine kinase activity//ATP binding//zinc ion binding GO:0005634//GO:0016020//GO:0005737//GO:0009357 nucleus//membrane//cytoplasm//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex -- -- Cluster-8309.31255 BP_3 362.40 5.84 3284 91086089 XP_967008.1 1467 1.7e-159 PREDICTED: XK-related protein 7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q49LS8 310 9.9e-27 XK-related protein 6 OS=Tetraodon nigroviridis GN=xkr6 PE=2 SV=1 PF03694//PF09815 Erg28 like protein//XK-related protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31256 BP_3 88.00 5.18 1110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31258 BP_3 13.55 0.42 1833 189240075 XP_001812636.1 712 3.3e-72 PREDICTED: protein singed wings 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SXT3 297 1.8e-25 Protein singed wings 2 OS=Drosophila melanogaster GN=swi2 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31260 BP_3 42.47 0.63 3532 642933227 XP_008197316.1 2898 0.0e+00 PREDICTED: uncharacterized protein LOC103314106 [Tribolium castaneum]>gi|270011449|gb|EFA07897.1| hypothetical protein TcasGA2_TC005472 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31263 BP_3 1388.85 7.87 8801 478262399 ENN81070.1 2351 1.4e-261 hypothetical protein YQE_02439, partial [Dendroctonus ponderosae]>gi|546673619|gb|ERL85183.1| hypothetical protein D910_02605 [Dendroctonus ponderosae] 830109730 XM_012729993.1 95 6.21486e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1140 1.5e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.31264 BP_3 191.48 5.55 1954 642915929 XP_008190815.1 330 6.9e-28 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050//PF01920//PF02895//PF01025//PF10473//PF05531//PF03938 Flagellar FliJ protein//Prefoldin subunit//Signal transducing histidine kinase, homodimeric domain//GrpE//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Nucleopolyhedrovirus P10 protein//Outer membrane protein (OmpH-like) GO:0000160//GO:0006457//GO:0006935//GO:0071973//GO:0016310 phosphorelay signal transduction system//protein folding//chemotaxis//bacterial-type flagellum-dependent cell motility//phosphorylation GO:0051087//GO:0051082//GO:0004673//GO:0000774//GO:0000155//GO:0008134//GO:0045502//GO:0042803//GO:0003774 chaperone binding//unfolded protein binding//protein histidine kinase activity//adenyl-nucleotide exchange factor activity//phosphorelay sensor kinase activity//transcription factor binding//dynein binding//protein homodimerization activity//motor activity GO:0009288//GO:0005737//GO:0016272//GO:0019028//GO:0016020//GO:0030286//GO:0005667//GO:0009365 bacterial-type flagellum//cytoplasm//prefoldin complex//viral capsid//membrane//dynein complex//transcription factor complex//protein histidine kinase complex -- -- Cluster-8309.31265 BP_3 149.00 5.10 1700 91083889 XP_974460.1 1221 2.9e-131 PREDICTED: UPF0553 protein C9orf64 homolog [Tribolium castaneum]>gi|270006749|gb|EFA03197.1| hypothetical protein TcasGA2_TC013117 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1JP73 727 2.3e-75 UPF0553 protein C9orf64 homolog OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2524 Cobyrinic acid a,c-diamide synthase Cluster-8309.31266 BP_3 213.79 11.43 1193 91077852 XP_971951.1 372 5.7e-33 PREDICTED: uncharacterized protein LOC660645 [Tribolium castaneum]>gi|270002261|gb|EEZ98708.1| hypothetical protein TcasGA2_TC001249 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06910 Male enhanced antigen 1 (MEA1) GO:0007283 spermatogenesis -- -- -- -- -- -- Cluster-8309.31269 BP_3 38.80 2.05 1202 642919747 XP_008192048.1 231 1.3e-16 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31270 BP_3 11.00 16.70 309 270004868 EFA01316.1 209 1.2e-14 hypothetical protein TcasGA2_TC003278 [Tribolium castaneum] -- -- -- -- -- K05465 ANGPT1 angiopoietin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05465 Q9WVH6 162 1.3e-10 Angiopoietin-4 OS=Mus musculus GN=Angpt4 PE=1 SV=1 PF00034 Cytochrome c GO:0006118 obsolete electron transport GO:0009055//GO:0020037 electron carrier activity//heme binding -- -- -- -- Cluster-8309.31271 BP_3 41.39 1.23 1912 189234413 XP_975276.2 833 3.2e-86 PREDICTED: uncharacterized protein LOC664170 isoform X1 [Tribolium castaneum] 642913234 XM_008203228.1 83 6.24065e-33 PREDICTED: Tribolium castaneum uncharacterized LOC664170 (LOC664170), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31273 BP_3 98.64 8.04 883 270001970 EEZ98417.1 662 9.9e-67 hypothetical protein TcasGA2_TC000885 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31275 BP_3 6.00 0.37 1074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31277 BP_3 1441.87 47.99 1740 642939867 XP_969882.2 2279 6.1e-254 PREDICTED: alpha-aminoadipic semialdehyde dehydrogenase [Tribolium castaneum] -- -- -- -- -- K14085 ALDH7A1 aldehyde dehydrogenase family 7 member A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14085 Q2KJC9 1753 2.5e-194 Alpha-aminoadipic semialdehyde dehydrogenase OS=Bos taurus GN=ALDH7A1 PE=2 SV=4 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.31278 BP_3 43.50 0.87 2697 478259695 ENN79539.1 871 1.8e-90 hypothetical protein YQE_04002, partial [Dendroctonus ponderosae]>gi|546679825|gb|ERL90217.1| hypothetical protein D910_07570 [Dendroctonus ponderosae] -- -- -- -- -- K05995 pepE dipeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K05995 Q91642 664 7.3e-68 Alpha-aspartyl dipeptidase OS=Xenopus laevis GN=aad-a PE=1 SV=1 PF03575 Peptidase family S51 GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- -- -- Cluster-8309.31279 BP_3 602.17 10.31 3106 270003083 EEZ99530.1 2513 8.1e-281 hypothetical protein TcasGA2_TC000112 [Tribolium castaneum] -- -- -- -- -- K13117 DHX35 ATP-dependent RNA helicase DDX35 http://www.genome.jp/dbget-bin/www_bget?ko:K13117 Q9H5Z1 1590 3.5e-175 Probable ATP-dependent RNA helicase DHX35 OS=Homo sapiens GN=DHX35 PE=1 SV=2 PF04408//PF00400//PF01436 Helicase associated domain (HA2)//WD domain, G-beta repeat//NHL repeat -- -- GO:0005515//GO:0004386 protein binding//helicase activity -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.3128 BP_3 4.00 0.31 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31280 BP_3 21.03 0.59 1997 642911571 XP_008199480.1 1995 6.0e-221 PREDICTED: solute carrier family 41 member 1-like [Tribolium castaneum] 642911570 XM_008201258.1 432 0 PREDICTED: Tribolium castaneum solute carrier family 41 member 1-like (LOC662863), mRNA K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1136 1.0e-122 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF04093 Divalent cation transporter//rod shape-determining protein MreD GO:0008360//GO:0006812 regulation of cell shape//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG3788 Predicted divalent cation transporter Cluster-8309.31281 BP_3 44.00 12.22 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.31282 BP_3 8.55 0.48 1157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31283 BP_3 7.56 0.44 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31284 BP_3 24.10 1.08 1372 91093675 XP_969585.1 997 2.2e-105 PREDICTED: traB domain-containing protein [Tribolium castaneum]>gi|270008075|gb|EFA04523.1| hypothetical protein TcasGA2_TC016318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99JY4 594 4.9e-60 TraB domain-containing protein OS=Mus musculus GN=Trabd PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2860 Uncharacterized conserved protein, contains TraB domain Cluster-8309.31285 BP_3 100.32 2.49 2237 91085939 XP_970530.1 645 2.3e-64 PREDICTED: longitudinals lacking protein-like [Tribolium castaneum]>gi|270010169|gb|EFA06617.1| hypothetical protein TcasGA2_TC009535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KRI2 601 1.2e-60 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31287 BP_3 76.00 2.39 1825 91076154 XP_970766.1 1141 5.9e-122 PREDICTED: venom protease [Tribolium castaneum]>gi|270015133|gb|EFA11581.1| serine protease P55 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5U2W0 758 6.2e-79 Venom serine protease Bi-VSP OS=Bombus ignitus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008236 serine-type endopeptidase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.31288 BP_3 5.98 0.34 1133 91089719 XP_974982.1 1497 1.9e-163 PREDICTED: methyltransferase-like protein 14 homolog [Tribolium castaneum]>gi|270012642|gb|EFA09090.1| hypothetical protein TcasGA2_TC006811 [Tribolium castaneum] 768446739 XM_011567022.1 103 2.78587e-44 PREDICTED: Plutella xylostella methyltransferase-like protein 14 homolog (LOC105395098), mRNA K05925 METTL3_14 mRNA (2'-O-methyladenosine-N6-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05925 Q9VLP7 1282 6.7e-140 Methyltransferase-like protein 14 homolog OS=Drosophila melanogaster GN=CG7818 PE=2 SV=1 PF05063 MT-A70 GO:0006139//GO:0032259 nucleobase-containing compound metabolic process//methylation GO:0008168 methyltransferase activity -- -- KOG2097 Predicted N6-adenine methylase involved in transcription regulation Cluster-8309.31291 BP_3 54.06 3.77 983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31292 BP_3 175.24 3.87 2472 546685044 ERL94598.1 1467 1.3e-159 hypothetical protein D910_11875 [Dendroctonus ponderosae] 768419811 XM_011552337.1 173 7.54912e-83 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P06801 1037 3.7e-111 NADP-dependent malic enzyme OS=Mus musculus GN=Me1 PE=1 SV=2 PF00390//PF03949//PF01420 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain//Type I restriction modification DNA specificity domain GO:0006090//GO:0006099//GO:0015976//GO:0006108//GO:0006304//GO:0055114 pyruvate metabolic process//tricarboxylic acid cycle//carbon utilization//malate metabolic process//DNA modification//oxidation-reduction process GO:0003677//GO:0051287//GO:0004471 DNA binding//NAD binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.31294 BP_3 1558.00 40.24 2158 91089627 XP_973479.1 2276 1.7e-253 PREDICTED: histone-binding protein RBBP4 [Tribolium castaneum]>gi|270012612|gb|EFA09060.1| hypothetical protein TcasGA2_TC006775 [Tribolium castaneum] 820847485 XM_003693377.2 567 0 PREDICTED: Apis florea probable histone-binding protein Caf1 (LOC100871885), mRNA K10752 RBBP4, HAT2, CAF1, MIS16 histone-binding protein RBBP4 http://www.genome.jp/dbget-bin/www_bget?ko:K10752 Q24572 2179 1.2e-243 Probable histone-binding protein Caf1 OS=Drosophila melanogaster GN=Caf1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding GO:0005634 nucleus KOG0264 Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 Cluster-8309.31296 BP_3 94.75 3.51 1594 189234066 XP_970272.2 1824 3.2e-201 PREDICTED: calcium uptake protein 3, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CD10 707 4.4e-73 Calcium uptake protein 2, mitochondrial OS=Mus musculus GN=Micu2 PE=1 SV=2 PF12763//PF13202//PF13499//PF00036//PF13405//PF13833 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.31297 BP_3 73.00 0.86 4371 270009864 EFA06312.1 3062 0.0e+00 hypothetical protein TcasGA2_TC009181 [Tribolium castaneum] 755980909 XM_011311102.1 314 5.57732e-161 PREDICTED: Fopius arisanus neuroendocrine convertase 2 (LOC105270270), mRNA K01360 PCSK2 proprotein convertase subtilisin/kexin type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K01360 P28841 1959 8.1e-218 Neuroendocrine convertase 2 OS=Rattus norvegicus GN=Pcsk2 PE=1 SV=1 PF01483//PF00082 Proprotein convertase P-domain//Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3526 Subtilisin-like proprotein convertase Cluster-8309.31298 BP_3 674.77 15.43 2399 332372937 AEE61610.1 1260 1.2e-135 unknown [Dendroctonus ponderosae]>gi|546684868|gb|ERL94450.1| hypothetical protein D910_11727 [Dendroctonus ponderosae] 758277713 KP113812.1 111 2.13943e-48 Acraea encedon voucher fj55_3 cytosolic malate dehydrogenase (Cmdh) gene, partial cds K00025 MDH1 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00025 Q5ZME2 1033 1.1e-110 Malate dehydrogenase, cytoplasmic OS=Gallus gallus GN=MDH1 PE=2 SV=1 PF00056//PF02866 lactate/malate dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114 oxidation-reduction process GO:0016616//GO:0016491 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1496 Malate dehydrogenase Cluster-8309.31299 BP_3 701.13 24.79 1655 91090526 XP_970144.1 693 4.7e-70 PREDICTED: UBX domain-containing protein 1 [Tribolium castaneum]>gi|270013875|gb|EFA10323.1| hypothetical protein TcasGA2_TC012540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GL77 271 1.7e-22 UBX domain-containing protein 1 OS=Xenopus tropicalis GN=ubxn1 PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG2689 Predicted ubiquitin regulatory protein Cluster-8309.31300 BP_3 15.92 0.74 1334 642917749 XP_008191355.1 1095 9.2e-117 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N9H8 421 5.4e-40 Exonuclease mut-7 homolog OS=Homo sapiens GN=EXD3 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2207 Predicted 3'-5' exonuclease Cluster-8309.31303 BP_3 63.00 3.31 1208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31304 BP_3 327.37 3.13 5329 270005044 EFA01492.1 6586 0.0e+00 hypothetical protein TcasGA2_TC007046 [Tribolium castaneum] 884965815 XM_010892944.2 162 2.13537e-76 PREDICTED: Esox lucius HECT domain containing E3 ubiquitin protein ligase 1 (hectd1), transcript variant X6, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 4691 0.0e+00 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF00023//PF13606//PF06701 Ankyrin repeat//Ankyrin repeat//Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872 ubiquitin-protein transferase activity//protein binding//metal ion binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.31307 BP_3 21.79 0.51 2357 91084421 XP_968215.1 911 3.5e-95 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 P35502 652 1.6e-66 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06467//PF07425//PF00326//PF07859 MYM-type Zinc finger with FCS sequence motif//Pardaxin//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0008270//GO:0016787 serine-type peptidase activity//zinc ion binding//hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.31308 BP_3 74.51 2.17 1950 189238236 XP_972123.2 193 5.3e-12 PREDICTED: guanine nucleotide-binding protein subunit gamma-e [Tribolium castaneum]>gi|270008671|gb|EFA05119.1| hypothetical protein TcasGA2_TC015232 [Tribolium castaneum] 743280388 KM065747.1 90 8.17816e-37 Culex quinquefasciatus clone C2B G-protein gamma-subunit mRNA, complete cds K04547 GNG13 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 http://www.genome.jp/dbget-bin/www_bget?ko:K04547 Q9NFZ2 179 9.1e-12 Guanine nucleotide-binding protein subunit gamma-e OS=Calliphora vicina PE=3 SV=1 PF00631 GGL domain GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex -- -- Cluster-8309.31310 BP_3 39.37 0.72 2917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.31311 BP_3 31.57 0.87 2049 270013069 EFA09517.1 847 8.1e-88 hypothetical protein TcasGA2_TC011619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXB0 698 6.3e-72 NECAP-like protein CG9132 OS=Drosophila melanogaster GN=CG9132 PE=2 SV=1 PF07933 Protein of unknown function (DUF1681) GO:0006897 endocytosis -- -- GO:0016020 membrane KOG2500 Uncharacterized conserved protein Cluster-8309.31312 BP_3 210.81 3.03 3645 642922869 XP_008200431.1 2031 7.4e-225 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1465 1.3e-160 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF03193//PF00664//PF01926//PF13304//PF12844//PF00236 ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Helix-turn-helix domain//Glycoprotein hormone GO:0007165//GO:0055085//GO:0006810 signal transduction//transmembrane transport//transport GO:0005525//GO:0043565//GO:0016887//GO:0042626//GO:0005524//GO:0005179//GO:0003924 GTP binding//sequence-specific DNA binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//hormone activity//GTPase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.31314 BP_3 9.00 0.69 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31315 BP_3 69.10 3.41 1268 642920261 XP_008192272.1 619 1.4e-61 PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920263|ref|XP_008192273.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920265|ref|XP_008192274.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920267|ref|XP_008192275.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|270005277|gb|EFA01725.1| hypothetical protein TcasGA2_TC007305 [Tribolium castaneum] -- -- -- -- -- K19480 ANO5, GDD1, TMEM16E anoctamin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K19480 Q75V66 183 2.0e-12 Anoctamin-5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 PF01091//PF16178 PTN/MK heparin-binding protein family, C-terminal domain//Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0008283//GO:0007165//GO:0040007//GO:0006811 cell proliferation//signal transduction//growth//ion transport GO:0046983//GO:0008083//GO:0005216 protein dimerization activity//growth factor activity//ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.31317 BP_3 12.38 0.54 1406 270009583 EFA06031.1 842 2.1e-87 hypothetical protein TcasGA2_TC008861 [Tribolium castaneum] -- -- -- -- -- K09646 SCPEP1 serine carboxypeptidase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09646 Q920A6 646 4.6e-66 Retinoid-inducible serine carboxypeptidase OS=Rattus norvegicus GN=Scpep1 PE=2 SV=1 PF00450 Serine carboxypeptidase GO:0006508 proteolysis GO:0004185 serine-type carboxypeptidase activity -- -- KOG1283 Serine carboxypeptidases Cluster-8309.31318 BP_3 81.79 0.74 5626 478257589 ENN77743.1 1238 1.0e-132 hypothetical protein YQE_05813, partial [Dendroctonus ponderosae]>gi|546677142|gb|ERL88039.1| hypothetical protein D910_05428 [Dendroctonus ponderosae] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 792 2.2e-82 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF02254//PF00389//PF00899//PF03446//PF02826//PF08783//PF15453//PF03435//PF02325//PF13241//PF01408 TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//ThiF family//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//DWNN domain//Protein incorporated later into Tight Junctions//Saccharopine dehydrogenase NADP binding domain//YGGT family//Putative NAD(P)-binding//Oxidoreductase family, NAD-binding Rossmann fold GO:0055114//GO:0006779//GO:0019521//GO:0006813//GO:0006098//GO:0008152//GO:0019354 oxidation-reduction process//porphyrin-containing compound biosynthetic process//D-gluconate metabolic process//potassium ion transport//pentose-phosphate shunt//metabolic process//siroheme biosynthetic process GO:0016616//GO:0004616//GO:0008270//GO:0051287//GO:0016491//GO:0043115//GO:0008641 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//zinc ion binding//NAD binding//oxidoreductase activity//precorrin-2 dehydrogenase activity//small protein activating enzyme activity GO:0005923//GO:0005634//GO:0016020 bicellular tight junction//nucleus//membrane -- -- Cluster-8309.31320 BP_3 9.00 0.88 784 641672832 XP_008186080.1 171 7.5e-10 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q867Z4 141 9.3e-08 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF01155//PF06524//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//NOA36 protein//BED zinc finger GO:0006464 cellular protein modification process GO:0046872//GO:0016151//GO:0003677//GO:0008270 metal ion binding//nickel cation binding//DNA binding//zinc ion binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.31322 BP_3 568.03 15.83 2021 642934979 XP_008199895.1 798 3.8e-82 PREDICTED: disintegrin and metalloproteinase domain-containing protein 12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31323 BP_3 35.85 0.91 2201 270012994 EFA09442.1 809 2.2e-83 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] 690066085 LM584766.1 40 5.76756e-09 Haemonchus placei genome assembly H_placei_MHpl1 ,scaffold HPLM_scaffold0001704 K06834 ADAM9 disintegrin and metalloproteinase domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06834 Q61072 287 3.1e-24 Disintegrin and metalloproteinase domain-containing protein 9 OS=Mus musculus GN=Adam9 PE=1 SV=2 PF06701 Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0046872 ubiquitin-protein transferase activity//metal ion binding -- -- KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family Cluster-8309.31324 BP_3 51.00 256.39 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31325 BP_3 14.65 1.66 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31327 BP_3 573.22 11.09 2782 189239791 XP_001811527.1 2811 0.0e+00 PREDICTED: oxysterol-binding protein 1 isoform X2 [Tribolium castaneum] 642930859 XM_001811475.2 237 2.2501e-118 PREDICTED: Tribolium castaneum oxysterol-binding protein 1 (LOC657071), transcript variant X2, mRNA -- -- -- -- P22059 1739 1.7e-192 Oxysterol-binding protein 1 OS=Homo sapiens GN=OSBP PE=1 SV=1 PF05854//PF02371 Non-histone chromosomal protein MC1//Transposase IS116/IS110/IS902 family GO:0042262//GO:0006313 DNA protection//transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- KOG1737 Oxysterol-binding protein Cluster-8309.31328 BP_3 826.06 14.54 3030 270003538 EEZ99985.1 2520 1.2e-281 hypothetical protein TcasGA2_TC002784 [Tribolium castaneum] 124087411 XM_001346809.1 35 4.7966e-06 Paramecium tetraurelia strain d4-2 >gnl|BL_ORD_ID|3811472 Paramecium tetraurelia hypothetical protein (GSPATT00000539001) partial mRNA K14571 RIX7, NVL ribosome biogenesis ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14571 O15381 1068 1.2e-114 Nuclear valosin-containing protein-like OS=Homo sapiens GN=NVL PE=1 SV=1 PF00910//PF10662//PF00005//PF07726//PF01118//PF01637//PF00437//PF07724//PF14532//PF05496//PF01443//PF06068//PF00931//PF02562//PF06414//PF02367//PF00004//PF01695//PF07728//PF01057//PF00158 RNA helicase//Ethanolamine utilisation - propanediol utilisation//ABC transporter//ATPase family associated with various cellular activities (AAA)//Semialdehyde dehydrogenase, NAD binding domain//Archaeal ATPase//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//TIP49 C-terminus//NB-ARC domain//PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain GO:0006281//GO:0006810//GO:0019079//GO:0055114//GO:0006355//GO:0006576//GO:0006310//GO:0002949 DNA repair//transport//viral genome replication//oxidation-reduction process//regulation of transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0005524//GO:0016620//GO:0016887//GO:0016301//GO:0043531//GO:0051287//GO:0003723//GO:0003678//GO:0003724//GO:0009378 transcription factor binding//ATP binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//ATPase activity//kinase activity//ADP binding//NAD binding//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005667//GO:0005657 Holliday junction helicase complex//transcription factor complex//replication fork KOG0733 Nuclear AAA ATPase (VCP subfamily) Cluster-8309.31329 BP_3 14.00 12.10 341 270004866 EFA01314.1 291 4.0e-24 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K06252 TN tenascin http://www.genome.jp/dbget-bin/www_bget?ko:K06252 A2AV25 217 6.2e-17 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31330 BP_3 84.55 3.94 1327 189235591 XP_968043.2 925 4.7e-97 PREDICTED: uncharacterized protein LOC656417 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31332 BP_3 1904.33 14.59 6581 478260541 ENN80244.1 792 6.2e-81 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 1.30864e-29 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q93096 517 2.0e-50 Protein tyrosine phosphatase type IVA 1 OS=Homo sapiens GN=PTP4A1 PE=1 SV=2 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.31333 BP_3 686.17 24.81 1625 270008621 EFA05069.1 151 3.3e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.31334 BP_3 351.41 3.14 5692 642919375 XP_008191845.1 1782 8.6e-196 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P35969 566 3.6e-56 Vascular endothelial growth factor receptor 1 OS=Mus musculus GN=Flt1 PE=1 SV=1 PF07714//PF06293//PF00069//PF01325//PF13895//PF02480 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Iron dependent repressor, N-terminal DNA binding domain//Immunoglobulin domain//Alphaherpesvirus glycoprotein E GO:0006468 protein phosphorylation GO:0003677//GO:0005524//GO:0016773//GO:0004672//GO:0005515 DNA binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.31335 BP_3 177.67 2.16 4264 642919375 XP_008191845.1 3290 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 831 5.0e-87 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF02480//PF13895//PF01325//PF00069//PF07714 Alphaherpesvirus glycoprotein E//Immunoglobulin domain//Iron dependent repressor, N-terminal DNA binding domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0003677//GO:0005524//GO:0005515//GO:0004672 DNA binding//ATP binding//protein binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.31337 BP_3 56.00 6.59 701 642940094 XP_008192960.1 524 7.9e-51 PREDICTED: paxillin isoform X5 [Tribolium castaneum] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8VI36 430 2.6e-41 Paxillin OS=Mus musculus GN=Pxn PE=1 SV=1 PF00412//PF00097 LIM domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.31338 BP_3 588.52 5.87 5128 546676645 ERL87609.1 2223 5.6e-247 hypothetical protein D910_05000, partial [Dendroctonus ponderosae] -- -- -- -- -- K04659 THBS2S thrombospondin 2/3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04659 P49747 1725 1.3e-190 Cartilage oligomeric matrix protein OS=Homo sapiens GN=COMP PE=1 SV=2 PF07645//PF00008//PF02412//PF05735 Calcium-binding EGF domain//EGF-like domain//Thrombospondin type 3 repeat//Thrombospondin C-terminal region GO:0007155 cell adhesion GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.31340 BP_3 42.15 0.96 2406 573896974 XP_006636225.1 151 4.8e-07 PREDICTED: tissue factor pathway inhibitor 2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- C0HJF3 141 2.9e-07 Analgesic polypeptide HC3 OS=Heteractis crispa PE=1 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.31344 BP_3 4663.52 47.79 4995 749735952 XP_011154160.1 3469 0.0e+00 PREDICTED: armadillo segment polarity protein isoform X1 [Harpegnathos saltator]>gi|307212553|gb|EFN88276.1| Armadillo segment polarity protein [Harpegnathos saltator] 642934620 XM_008199519.1 694 0 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 3286 0.0e+00 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 PF07646//PF02985//PF10508//PF01344//PF00514//PF01602 Kelch motif//HEAT repeat//Proteasome non-ATPase 26S subunit//Kelch motif//Armadillo/beta-catenin-like repeat//Adaptin N terminal region GO:0043248//GO:0016192//GO:0006886 proteasome assembly//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.31346 BP_3 23.00 1.49 1036 699253217 XP_009861051.1 140 3.9e-06 PREDICTED: ovochymase-1-like [Ciona intestinalis] -- -- -- -- -- -- -- -- -- Q90WD8 138 2.7e-07 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31347 BP_3 28.95 2.64 821 642931082 XP_008196202.1 474 5.8e-45 PREDICTED: aquaporin-12 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31348 BP_3 66.15 7.91 695 270012071 EFA08519.1 525 6.0e-51 hypothetical protein TcasGA2_TC006172 [Tribolium castaneum] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 -- -- -- -- PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.31349 BP_3 30.31 0.69 2404 332373408 AEE61845.1 1537 9.3e-168 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 563 3.3e-56 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.3135 BP_3 3.00 0.68 503 817328905 XP_012291424.1 516 4.8e-50 PREDICTED: 40S ribosomal protein S15 isoform X1 [Aotus nancymaae] 815891094 NM_001018.4 487 0 Homo sapiens ribosomal protein S15 (RPS15), transcript variant 2, mRNA K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 Q5RDI7 483 1.3e-47 40S ribosomal protein S15 OS=Pongo abelii GN=RPS15 PE=2 SV=3 PF03999//PF02450//PF00203 Microtubule associated protein (MAP65/ASE1 family)//Lecithin:cholesterol acyltransferase//Ribosomal protein S19 GO:0042967//GO:0006412//GO:0006629//GO:0000910//GO:0042254//GO:0000226 acyl-carrier-protein biosynthetic process//translation//lipid metabolic process//cytokinesis//ribosome biogenesis//microtubule cytoskeleton organization GO:0008374//GO:0003735//GO:0008017 O-acyltransferase activity//structural constituent of ribosome//microtubule binding GO:0045298//GO:0005840 tubulin complex//ribosome KOG0898 40S ribosomal protein S15 Cluster-8309.31350 BP_3 12.85 0.40 1834 270012071 EFA08519.1 269 7.7e-21 hypothetical protein TcasGA2_TC006172 [Tribolium castaneum] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 -- -- -- -- PF01914//PF01967 MarC family integral membrane protein//MoaC family GO:0006777 Mo-molybdopterin cofactor biosynthetic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31351 BP_3 4.33 0.41 800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31354 BP_3 2668.05 122.09 1345 478251082 ENN71558.1 897 8.5e-94 hypothetical protein YQE_11660, partial [Dendroctonus ponderosae]>gi|546671909|gb|ERL84016.1| hypothetical protein D910_01335 [Dendroctonus ponderosae]>gi|546671968|gb|ERL84050.1| hypothetical protein D910_01379 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P04572 289 1.1e-24 Sarcoplasmic calcium-binding protein OS=Perinereis vancaurica tetradentata PE=1 SV=1 PF13499//PF05983//PF10591//PF13833//PF00036//PF13405//PF13202 EF-hand domain pair//MED7 protein//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF hand GO:0007165//GO:0006357 signal transduction//regulation of transcription from RNA polymerase II promoter GO:0005509//GO:0001104 calcium ion binding//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005578 mediator complex//proteinaceous extracellular matrix -- -- Cluster-8309.31355 BP_3 29.70 0.72 2287 642913868 XP_008201196.1 827 1.9e-85 PREDICTED: leucine-rich repeat-containing protein C10orf11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D9B4 539 1.9e-53 Leucine-rich repeat-containing protein C10orf11 homolog OS=Mus musculus PE=2 SV=1 PF02963//PF13855//PF05955//PF00560 Restriction endonuclease EcoRI//Leucine rich repeat//Equine herpesvirus glycoprotein gp2//Leucine Rich Repeat GO:0006308//GO:0009307//GO:0016032 DNA catabolic process//DNA restriction-modification system//viral process GO:0000287//GO:0005515//GO:0009036//GO:0003677 magnesium ion binding//protein binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359//GO:0016021 Type II site-specific deoxyribonuclease complex//integral component of membrane KOG1644 U2-associated snRNP A' protein Cluster-8309.31357 BP_3 1063.89 93.19 842 642919270 XP_008191803.1 234 4.0e-17 PREDICTED: copper transport protein ATOX1 [Tribolium castaneum] -- -- -- -- -- K07213 ATOX1, ATX1, copZ, golB copper chaperone http://www.genome.jp/dbget-bin/www_bget?ko:K07213 Q94BT9 163 2.8e-10 Copper transport protein ATX1 OS=Arabidopsis thaliana GN=ATX1 PE=1 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG1603 Copper chaperone Cluster-8309.31360 BP_3 608.35 5.66 5469 91082253 XP_973026.1 3234 0.0e+00 PREDICTED: elongation factor G, mitochondrial [Tribolium castaneum] 170040110 XM_001847803.1 294 9.17096e-150 Culex quinquefasciatus elongation factor G 1, mitochondrial, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 Q9VM33 3037 0.0e+00 Elongation factor G, mitochondrial OS=Drosophila melanogaster GN=ico PE=2 SV=2 PF03764//PF04548//PF00922//PF03144//PF05485//PF01926 Elongation factor G, domain IV//AIG1 family//Vesiculovirus phosphoprotein//Elongation factor Tu domain 2//THAP domain//50S ribosome-binding GTPase GO:0006144 purine nucleobase metabolic process GO:0003676//GO:0005525//GO:0003968 nucleic acid binding//GTP binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG0465 Mitochondrial elongation factor Cluster-8309.31362 BP_3 167.00 12.44 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31363 BP_3 96.67 4.78 1267 642913478 XP_008201029.1 407 5.2e-37 PREDICTED: dolichol kinase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31365 BP_3 132.00 3.04 2387 641661214 XP_008181794.1 635 3.6e-63 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q03923 613 5.3e-62 Zinc finger protein 85 OS=Homo sapiens GN=ZNF85 PE=1 SV=3 PF13465//PF00096//PF13912//PF00999//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Sodium/hydrogen exchanger family//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0055085//GO:0006885//GO:0006812 transmembrane transport//regulation of pH//cation transport GO:0015299//GO:0008270//GO:0046872 solute:proton antiporter activity//zinc ion binding//metal ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.31366 BP_3 12.03 0.56 1330 193596505 XP_001945593.1 330 4.7e-28 PREDICTED: 26S protease regulatory subunit 6B [Acyrthosiphon pisum] 195350827 XM_002041904.1 113 9.05997e-50 Drosophila sechellia GM11458 (Dsec\GM11458), mRNA K03063 PSMC4, RPT3 26S proteasome regulatory subunit T3 http://www.genome.jp/dbget-bin/www_bget?ko:K03063 P46507 308 6.8e-27 26S protease regulatory subunit 6B OS=Manduca sexta PE=2 SV=1 PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- KOG0727 26S proteasome regulatory complex, ATPase RPT3 Cluster-8309.31369 BP_3 459.79 7.45 3266 642935994 XP_008198261.1 2201 1.3e-244 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X4 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1685 3.6e-186 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.3137 BP_3 3.00 0.33 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31370 BP_3 11.41 0.55 1297 91081359 XP_971395.1 1297 3.4e-140 PREDICTED: tumor suppressor candidate 3 [Tribolium castaneum]>gi|270005188|gb|EFA01636.1| hypothetical protein TcasGA2_TC007206 [Tribolium castaneum] 571501133 XM_395605.5 180 5.02136e-87 PREDICTED: Apis mellifera magnesium transporter protein 1-like (LOC412141), mRNA K12669 OST3, OST6 oligosaccharyltransferase complex subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K12669 Q8BTV1 993 2.5e-106 Tumor suppressor candidate 3 OS=Mus musculus GN=Tusc3 PE=2 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2603 Oligosaccharyltransferase, gamma subunit Cluster-8309.31371 BP_3 656.88 9.55 3606 642928339 XP_008195541.1 1614 1.6e-176 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog-like isoform X1 [Tribolium castaneum] 571531697 XM_006570187.1 76 9.23795e-29 PREDICTED: Apis mellifera synaptic vesicle membrane protein VAT-1 homolog-like (LOC409207), mRNA -- -- -- -- Q9HCJ6 992 9.0e-106 Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens GN=VAT1L PE=1 SV=2 PF10152//PF08240//PF00951//PF02862//PF01118//PF02724//PF06459//PF00107 Predicted coiled-coil domain-containing protein (DUF2360)//Alcohol dehydrogenase GroES-like domain//Arterivirus GL envelope glycoprotein//DDHD domain//Semialdehyde dehydrogenase, NAD binding domain//CDC45-like protein//Ryanodine Receptor TM 4-6//Zinc-binding dehydrogenase GO:0055114//GO:0006874//GO:0006270//GO:0006816 oxidation-reduction process//cellular calcium ion homeostasis//DNA replication initiation//calcium ion transport GO:0046872//GO:0016620//GO:0051287//GO:0005219 metal ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding//ryanodine-sensitive calcium-release channel activity GO:0071203//GO:0005622//GO:0019031//GO:0016021 WASH complex//intracellular//viral envelope//integral component of membrane KOG1197 Predicted quinone oxidoreductase Cluster-8309.31373 BP_3 92.81 1.22 3953 642918588 XP_008197437.1 1427 8.7e-155 PREDICTED: RNA-binding Raly-like protein [Tribolium castaneum] 642918587 XM_008199215.1 344 1.06043e-177 PREDICTED: Tribolium castaneum RNA-binding Raly-like protein (LOC103314137), mRNA -- -- -- -- P19600 314 4.1e-27 Heterogeneous nuclear ribonucleoprotein C OS=Xenopus laevis GN=hnrnpc PE=2 SV=1 PF00096//PF00076 Zinc finger, C2H2 type//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0046872 nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.31374 BP_3 211.11 6.43 1874 478255055 ENN75285.1 838 8.2e-87 hypothetical protein YQE_08062, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31379 BP_3 9.00 0.39 1395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31380 BP_3 114.38 1.28 4589 642913880 XP_008201199.1 1003 1.5e-105 PREDICTED: uncharacterized protein LOC664073 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q99N48 187 2.5e-12 Synaptotagmin-like protein 3 OS=Mus musculus GN=Sytl3 PE=1 SV=2 PF01363//PF05715 FYVE zinc finger//Piccolo Zn-finger -- -- GO:0046872 metal ion binding GO:0045202 synapse -- -- Cluster-8309.31381 BP_3 195.06 1.24 7904 642913878 XP_975183.2 7115 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X1 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.54017e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q96C24 760 1.6e-78 Synaptotagmin-like protein 4 OS=Homo sapiens GN=SYTL4 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.31382 BP_3 416.16 2.12 9766 642929667 XP_008195928.1 6968 0.0e+00 PREDICTED: probable Rho GTPase-activating protein CG5521 isoform X1 [Tribolium castaneum] 642929668 XM_970393.2 238 2.21583e-118 PREDICTED: Tribolium castaneum probable Rho GTPase-activating protein CG5521 (LOC664386), transcript variant X2, mRNA -- -- -- -- Q9VB98 2114 1.9e-235 Probable Rho GTPase-activating protein CG5521 OS=Drosophila melanogaster GN=CG5521 PE=1 SV=2 PF02145//PF03367//PF04135//PF03110//PF00130//PF01155 Rap/ran-GAP//ZPR1 zinc-finger domain//Nucleolar RNA-binding protein, Nop10p family//SBP domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0042254//GO:0035556//GO:0001522//GO:0051056 cellular protein modification process//ribosome biogenesis//intracellular signal transduction//pseudouridine synthesis//regulation of small GTPase mediated signal transduction GO:0016151//GO:0030515//GO:0005096//GO:0003677//GO:0008270 nickel cation binding//snoRNA binding//GTPase activator activity//DNA binding//zinc ion binding GO:0005634//GO:0072588 nucleus//box H/ACA RNP complex KOG2703 C4-type Zn-finger protein Cluster-8309.31383 BP_3 8463.50 24.47 16960 270012570 EFA09018.1 2931 0.0e+00 hypothetical protein TcasGA2_TC006727 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07929 194 1.4e-12 63 kDa sperm flagellar membrane protein OS=Strongylocentrotus purpuratus PE=2 SV=1 PF00008//PF00335//PF07645 EGF-like domain//Tetraspanin family//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021 integral component of membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.31386 BP_3 442.00 20.86 1313 189235452 XP_971512.2 1546 4.6e-169 PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum]>gi|642916717|ref|XP_008192324.1| PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum] 831223446 XM_012804270.1 56 4.34024e-18 PREDICTED: Otolemur garnettii coiled-coil domain containing 102B (CCDC102B), mRNA K16759 CCDC102A coiled-coil domain-containing protein 102A http://www.genome.jp/dbget-bin/www_bget?ko:K16759 Q6NZW0 743 2.4e-77 Coiled-coil domain-containing protein 102A OS=Danio rerio GN=ccdc102a PE=2 SV=1 PF04513//PF00038//PF04111 Baculovirus polyhedron envelope protein, PEP, C terminus//Intermediate filament protein//Autophagy protein Apg6 GO:0006914 autophagy GO:0005198 structural molecule activity GO:0019028//GO:0005882//GO:0019031 viral capsid//intermediate filament//viral envelope -- -- Cluster-8309.31388 BP_3 868.63 5.67 7677 91082255 XP_973064.1 2364 3.8e-263 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62046 915 1.6e-96 Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Mus musculus GN=Lrch1 PE=1 SV=2 PF00307//PF13855//PF00560 Calponin homology (CH) domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.31390 BP_3 53.03 1.09 2644 642927864 XP_008195430.1 2022 5.9e-224 PREDICTED: inhibitor of Bruton tyrosine kinase [Tribolium castaneum]>gi|270010253|gb|EFA06701.1| hypothetical protein TcasGA2_TC009632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPR6 1122 5.6e-121 Inhibitor of Bruton tyrosine kinase OS=Mus musculus GN=Ibtk PE=1 SV=3 PF13606//PF05224//PF00651//PF00023 Ankyrin repeat//NDT80 / PhoG like DNA-binding family//BTB/POZ domain//Ankyrin repeat -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0783 Uncharacterized conserved protein, contains ankyrin and BTB/POZ domains Cluster-8309.31392 BP_3 8.16 0.51 1069 642913226 XP_975254.2 496 2.1e-47 PREDICTED: protein CutA homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K03926 cutA periplasmic divalent cation tolerance protein http://www.genome.jp/dbget-bin/www_bget?ko:K03926 Q66KY3 390 1.7e-36 Protein CutA homolog OS=Xenopus laevis GN=cuta PE=2 SV=2 PF03091 CutA1 divalent ion tolerance protein GO:0010038 response to metal ion -- -- -- -- KOG3338 Divalent cation tolerance-related protein Cluster-8309.31393 BP_3 5097.14 34.92 7327 91085649 XP_970922.1 6731 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum]>gi|270011037|gb|EFA07485.1| hypothetical protein TcasGA2_TC009375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R422 759 1.9e-78 CD109 antigen OS=Mus musculus GN=Cd109 PE=2 SV=1 PF00057//PF00432//PF00207//PF07678//PF01835//PF06617//PF07677 Low-density lipoprotein receptor domain class A//Prenyltransferase and squalene oxidase repeat//Alpha-2-macroglobulin family//A-macroglobulin complement component//MG2 domain//M-phase inducer phosphatase//A-macroglobulin receptor GO:0010951//GO:0006570//GO:0000087//GO:0006470 negative regulation of endopeptidase activity//tyrosine metabolic process//mitotic M phase//protein dephosphorylation GO:0003824//GO:0004866//GO:0005515//GO:0004725 catalytic activity//endopeptidase inhibitor activity//protein binding//protein tyrosine phosphatase activity GO:0005576//GO:0005622//GO:0005615 extracellular region//intracellular//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.31395 BP_3 121.00 4.56 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31396 BP_3 159.36 4.88 1866 91091818 XP_966528.1 1362 1.4e-147 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 961 1.8e-102 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007268//GO:0006811//GO:0007165 synaptic transmission//ion transport//signal transduction GO:0004970//GO:0005234//GO:0005216 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity//ion channel activity GO:0016020 membrane -- -- Cluster-8309.31397 BP_3 172.00 5.04 1936 91081383 XP_972269.1 910 3.8e-95 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 1 [Tribolium castaneum]>gi|642920804|ref|XP_008192568.1| PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 1 [Tribolium castaneum]>gi|642920806|ref|XP_008192569.1| PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 1 [Tribolium castaneum]>gi|270006117|gb|EFA02565.1| hypothetical protein TcasGA2_TC008275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 264 1.3e-21 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.31398 BP_3 198.00 21.87 728 91080781 XP_968744.1 585 6.9e-58 PREDICTED: 40S ribosomal protein S12, mitochondrial [Tribolium castaneum]>gi|270005434|gb|EFA01882.1| hypothetical protein TcasGA2_TC007491 [Tribolium castaneum] -- -- -- -- -- K02950 RP-S12, MRPS12, rpsL small subunit ribosomal protein S12 http://www.genome.jp/dbget-bin/www_bget?ko:K02950 P10735 447 2.9e-43 40S ribosomal protein S12, mitochondrial OS=Drosophila melanogaster GN=tko PE=1 SV=1 PF00164 Ribosomal protein S12/S23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0015935//GO:0005840 intracellular//small ribosomal subunit//ribosome KOG1750 Mitochondrial/chloroplast ribosomal protein S12 Cluster-8309.31403 BP_3 17.00 2.47 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- O81338 132 8.2e-07 Antimicrobial peptide 1 OS=Mesembryanthemum crystallinum PE=3 SV=1 PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31404 BP_3 16.36 1.81 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31405 BP_3 34.89 0.38 4739 270001801 EEZ98248.1 687 6.7e-69 hypothetical protein TcasGA2_TC000687 [Tribolium castaneum] -- -- -- -- -- K13781 SLC7A8, LAT2 solute carrier family 7 (L-type amino acid transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13781 Q9N1Q4 456 1.7e-43 Large neutral amino acids transporter small subunit 2 OS=Oryctolagus cuniculus GN=SLC7A8 PE=1 SV=1 PF13520//PF01990//PF01424//PF00324 Amino acid permease//ATP synthase (F/14-kDa) subunit//R3H domain//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0034220//GO:0003333 transmembrane transport//amino acid transport//transport//ion transmembrane transport//amino acid transmembrane transport GO:0015171//GO:0003676 amino acid transmembrane transporter activity//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.3141 BP_3 2.05 0.34 578 332376166 AEE63223.1 396 4.5e-36 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q86BN8 297 5.6e-26 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Drosophila melanogaster GN=Plip PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1719 Dual specificity phosphatase Cluster-8309.31410 BP_3 59.04 6.68 718 91083623 XP_970124.1 965 5.9e-102 PREDICTED: probable citrate synthase 2, mitochondrial [Tribolium castaneum]>gi|270006831|gb|EFA03279.1| hypothetical protein TcasGA2_TC013214 [Tribolium castaneum] 755984491 XM_011312239.1 134 1.01441e-61 PREDICTED: Fopius arisanus probable citrate synthase 2, mitochondrial (LOC105270973), transcript variant X2, mRNA K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q16P20 896 2.4e-95 Probable citrate synthase 2, mitochondrial OS=Aedes aegypti GN=AAEL011789 PE=3 SV=1 PF00285 Citrate synthase GO:0046487//GO:0006099//GO:0044262 glyoxylate metabolic process//tricarboxylic acid cycle//cellular carbohydrate metabolic process GO:0004108//GO:0046912 citrate (Si)-synthase activity//transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer -- -- KOG2617 Citrate synthase Cluster-8309.31411 BP_3 966.27 16.33 3143 91083623 XP_970124.1 1221 5.3e-131 PREDICTED: probable citrate synthase 2, mitochondrial [Tribolium castaneum]>gi|270006831|gb|EFA03279.1| hypothetical protein TcasGA2_TC013214 [Tribolium castaneum] 332373859 BT127109.1 235 3.29333e-117 Dendroctonus ponderosae clone DPO016_K18 unknown mRNA K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q17GM7 1151 2.9e-124 Probable citrate synthase 1, mitochondrial OS=Aedes aegypti GN=AAEL002956 PE=3 SV=1 PF00285//PF02892//PF16622//PF01429//PF00320//PF00096//PF13465 Citrate synthase//BED zinc finger//zinc-finger C2H2-type//Methyl-CpG binding domain//GATA zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006099//GO:0006355//GO:0044262//GO:0046487 tricarboxylic acid cycle//regulation of transcription, DNA-templated//cellular carbohydrate metabolic process//glyoxylate metabolic process GO:0008270//GO:0043565//GO:0004108//GO:0003700//GO:0046872//GO:0046912//GO:0003677 zinc ion binding//sequence-specific DNA binding//citrate (Si)-synthase activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer//DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG2617 Citrate synthase Cluster-8309.31412 BP_3 58.64 1.41 2290 642937652 XP_966876.3 580 8.3e-57 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17010 364 3.8e-33 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF07776//PF02751//PF05401//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Transcription initiation factor IIA, gamma subunit//Nodulation protein S (NodS)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0009877//GO:0006367//GO:0009312 nodulation//transcription initiation from RNA polymerase II promoter//oligosaccharide biosynthetic process GO:0008270//GO:0046872//GO:0008757 zinc ion binding//metal ion binding//S-adenosylmethionine-dependent methyltransferase activity GO:0005672//GO:0005634 transcription factor TFIIA complex//nucleus -- -- Cluster-8309.31414 BP_3 111.00 19.15 571 642920639 XP_008192499.1 329 2.6e-28 PREDICTED: uncharacterized protein LOC103312788 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31417 BP_3 12.00 0.85 970 780089478 XP_011673857.1 343 1.1e-29 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 249 3.5e-20 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31419 BP_3 15.00 1.85 683 780089478 XP_011673857.1 246 1.3e-18 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q8N8A2 204 4.0e-15 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens GN=ANKRD44 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31420 BP_3 3.00 0.56 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31421 BP_3 3426.77 71.31 2608 91078216 XP_969175.1 1172 2.1e-125 PREDICTED: surfeit locus protein 4 homolog [Tribolium castaneum]>gi|270001352|gb|EEZ97799.1| hypothetical protein TcasGA2_TC000161 [Tribolium castaneum] 225718617 BT080731.1 73 3.09866e-27 Caligus clemensi clone ccle-evs-519-002 Surfeit locus protein 4 homolog putative mRNA, complete cds K03593 mrp, NUBPL ATP-binding protein involved in chromosome partitioning http://www.genome.jp/dbget-bin/www_bget?ko:K03593 O18405 988 1.9e-105 Surfeit locus protein 4 homolog OS=Drosophila melanogaster GN=Surf4 PE=2 SV=1 PF02077//PF03419 SURF4 family//Sporulation factor SpoIIGA GO:0030436//GO:0006508 asexual sporulation//proteolysis GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.31423 BP_3 194.00 165.21 342 501298484 BAN21346.1 219 8.9e-16 unkown protein [Riptortus pedestris] -- -- -- -- -- K00419 QCR9, UCRC ubiquinol-cytochrome c reductase subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K00419 P00130 178 2.1e-12 Cytochrome b-c1 complex subunit 9 OS=Bos taurus GN=UQCR10 PE=1 SV=3 PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005743//GO:0005750 mitochondrial inner membrane//mitochondrial respiratory chain complex III -- -- Cluster-8309.31424 BP_3 40.04 0.80 2697 91089013 XP_968301.1 2664 2.2e-298 PREDICTED: RINT1-like protein [Tribolium castaneum]>gi|270011539|gb|EFA07987.1| hypothetical protein TcasGA2_TC005574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUQ1 1052 7.4e-113 RAD50-interacting protein 1 OS=Homo sapiens GN=RINT1 PE=1 SV=1 PF08702//PF04437//PF05384//PF06008 Fibrinogen alpha/beta chain family//RINT-1 / TIP-1 family//Sensor protein DegS//Laminin Domain I GO:0051258//GO:0048193//GO:0007165//GO:0030334//GO:0045995//GO:0030155//GO:0030168 protein polymerization//Golgi vesicle transport//signal transduction//regulation of cell migration//regulation of embryonic development//regulation of cell adhesion//platelet activation GO:0030674//GO:0005102//GO:0016301 protein binding, bridging//receptor binding//kinase activity GO:0005783//GO:0005577 endoplasmic reticulum//fibrinogen complex -- -- Cluster-8309.31425 BP_3 177.56 18.24 761 91080601 XP_974038.1 569 5.2e-56 PREDICTED: mediator of RNA polymerase II transcription subunit 7 [Tribolium castaneum]>gi|270005511|gb|EFA01959.1| hypothetical protein TcasGA2_TC007575 [Tribolium castaneum] -- -- -- -- -- K15148 MED7 mediator of RNA polymerase II transcription subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15148 Q7PR68 365 9.6e-34 Mediator of RNA polymerase II transcription subunit 7 OS=Anopheles gambiae GN=MED7 PE=3 SV=2 PF00042 Globin GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0020037//GO:0001104//GO:0019825 heme binding//RNA polymerase II transcription cofactor activity//oxygen binding GO:0016592 mediator complex KOG0570 Transcriptional coactivator Cluster-8309.31426 BP_3 195.84 1.48 6663 817053828 XP_012264100.1 1826 7.9e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935876 XR_511652.1 647 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X4, misc_RNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 Q9UBE8 1597 1.2e-175 Serine/threonine-protein kinase NLK OS=Homo sapiens GN=NLK PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.31429 BP_3 25.13 0.36 3618 270003759 EFA00207.1 1136 4.4e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.31245e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.3e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.31432 BP_3 49.82 1.28 2173 91083611 XP_969629.1 878 2.2e-91 PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|642924148|ref|XP_008194028.1| PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|270006834|gb|EFA03282.1| hypothetical protein TcasGA2_TC013217 [Tribolium castaneum] -- -- -- -- -- K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 Q86VD7 558 1.1e-55 Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens GN=SLC25A42 PE=2 SV=2 -- -- GO:0006810 transport -- -- GO:0016020 membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.31434 BP_3 26.61 0.61 2384 642910653 XP_968714.2 283 2.4e-22 PREDICTED: polyadenylate-binding protein-interacting protein 2B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31435 BP_3 78.00 1.87 2305 91091370 XP_972940.1 1297 6.0e-140 PREDICTED: radical S-adenosyl methionine domain-containing protein 2 [Tribolium castaneum]>gi|270013064|gb|EFA09512.1| hypothetical protein TcasGA2_TC011614 [Tribolium castaneum] -- -- -- -- -- K15045 RSAD2 radical S-adenosyl methionine domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15045 Q2HJF9 1128 9.8e-122 Radical S-adenosyl methionine domain-containing protein 2 OS=Bos taurus GN=RSAD2 PE=2 SV=1 PF04055 Radical SAM superfamily GO:0008152//GO:0051607 metabolic process//defense response to virus GO:0051536//GO:0003824 iron-sulfur cluster binding//catalytic activity GO:0005789//GO:0005811 endoplasmic reticulum membrane//lipid particle -- -- Cluster-8309.31436 BP_3 42.00 3.67 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31439 BP_3 16.72 0.76 1351 270002027 EEZ98474.1 452 3.4e-42 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWD0 135 8.0e-07 Gametocyte-specific factor 1-like OS=Mus musculus GN=Gtsf1l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4376 Uncharacterized conserved protein Cluster-8309.3144 BP_3 13.66 0.44 1773 91093355 XP_969078.1 1073 4.4e-114 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IWG1 378 7.0e-35 WD repeat-containing protein 63 OS=Homo sapiens GN=WDR63 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.31440 BP_3 212.09 1.34 7948 642911937 XP_008199029.1 3496 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 610 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1868 5.3e-207 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF03114//PF14604//PF00023//PF00018//PF08397//PF07043//PF00885//PF13606//PF00465//PF01412 BAR domain//Variant SH3 domain//Ankyrin repeat//SH3 domain//IRSp53/MIM homology domain//Protein of unknown function (DUF1328)//6,7-dimethyl-8-ribityllumazine synthase//Ankyrin repeat//Iron-containing alcohol dehydrogenase//Putative GTPase activating protein for Arf GO:0009231//GO:0007009//GO:0055114 riboflavin biosynthetic process//plasma membrane organization//oxidation-reduction process GO:0005096//GO:0005515//GO:0016491//GO:0046872 GTPase activator activity//protein binding//oxidoreductase activity//metal ion binding GO:0005886//GO:0009349//GO:0005737 plasma membrane//riboflavin synthase complex//cytoplasm KOG3857 Alcohol dehydrogenase, class IV Cluster-8309.31442 BP_3 1123.21 7.44 7568 642917303 XP_008199243.1 7219 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X4 [Tribolium castaneum] 642917302 XM_008201021.1 1251 0 PREDICTED: Tribolium castaneum disco-interacting protein 2 (LOC657292), transcript variant X4, mRNA -- -- -- -- Q9W0S9 5111 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF17096//PF06464//PF00501 Altered inheritance of mitochondria protein 3//DMAP1-binding Domain//AMP-binding enzyme GO:0051016//GO:0008152 barbed-end actin filament capping//metabolic process GO:0003824//GO:0008134 catalytic activity//transcription factor binding GO:0030479//GO:0005634//GO:0005667 actin cortical patch//nucleus//transcription factor complex KOG3628 Predicted AMP-binding protein Cluster-8309.31443 BP_3 1364.00 51.19 1576 189239379 XP_971918.2 694 3.4e-70 PREDICTED: receptor expression-enhancing protein 5 [Tribolium castaneum]>gi|270009667|gb|EFA06115.1| hypothetical protein TcasGA2_TC008958 [Tribolium castaneum] -- -- -- -- -- K17279 REEP5_6 receptor expression-enhancing protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K17279 Q5RE33 493 2.9e-48 Receptor expression-enhancing protein 5 OS=Pongo abelii GN=REEP5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.31446 BP_3 991.91 5.52 8953 642917303 XP_008199243.1 7005 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X4 [Tribolium castaneum] 665815961 XM_008558446.1 643 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3668 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF06464//PF02710//PF02784//PF00501 DMAP1-binding Domain//Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein//Pyridoxal-dependent decarboxylase, pyridoxal binding domain//AMP-binding enzyme GO:0007165//GO:0008152//GO:0019064 signal transduction//metabolic process//fusion of virus membrane with host plasma membrane GO:0046789//GO:0003824//GO:0016788//GO:0008134 host cell surface receptor binding//catalytic activity//hydrolase activity, acting on ester bonds//transcription factor binding GO:0009986//GO:0005634//GO:0005667//GO:0019031 cell surface//nucleus//transcription factor complex//viral envelope KOG3628 Predicted AMP-binding protein Cluster-8309.31448 BP_3 107.65 5.42 1249 91083635 XP_970519.1 1462 2.4e-159 PREDICTED: hydroxyacid oxidase 1 [Tribolium castaneum] -- -- -- -- -- K11517 HAO (S)-2-hydroxy-acid oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K11517 Q9UJM8 1028 2.1e-110 Hydroxyacid oxidase 1 OS=Homo sapiens GN=HAO1 PE=1 SV=1 PF00977//PF00478//PF03060//PF04309//PF01070//PF01645//PF01180 Histidine biosynthesis protein//IMP dehydrogenase / GMP reductase domain//Nitronate monooxygenase//Glycerol-3-phosphate responsive antiterminator//FMN-dependent dehydrogenase//Conserved region in glutamate synthase//Dihydroorotate dehydrogenase GO:0009607//GO:0006355//GO:0000105//GO:0006807//GO:0055114//GO:0006537 response to biotic stimulus//regulation of transcription, DNA-templated//histidine biosynthetic process//nitrogen compound metabolic process//oxidation-reduction process//glutamate biosynthetic process GO:0016638//GO:0015930//GO:0016627//GO:0018580//GO:0003824//GO:0016491 oxidoreductase activity, acting on the CH-NH2 group of donors//glutamate synthase activity//oxidoreductase activity, acting on the CH-CH group of donors//nitronate monooxygenase activity//catalytic activity//oxidoreductase activity GO:0005737 cytoplasm KOG0538 Glycolate oxidase Cluster-8309.31449 BP_3 615.00 6.76 4677 189234745 XP_974217.2 4064 0.0e+00 PREDICTED: tetratricopeptide repeat protein 21B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z4L5 2203 4.4e-246 Tetratricopeptide repeat protein 21B OS=Homo sapiens GN=TTC21B PE=1 SV=2 PF13414//PF13174//PF13176//PF13371//PF00515//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31450 BP_3 18273.38 618.83 1715 270004718 EFA01166.1 2156 1.1e-239 hypothetical protein TcasGA2_TC010489 [Tribolium castaneum] 156481745 EU093075.1 889 0 Monochamus alternatus laccase 2 mRNA, complete cds -- -- -- -- Q99056 454 1.0e-43 Laccase-5 OS=Trametes villosa GN=LCC5 PE=3 SV=2 PF00394//PF07732//PF07731 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- KOG1263 Multicopper oxidases Cluster-8309.31451 BP_3 60.68 1.74 1969 91076790 XP_974060.1 878 2.0e-91 PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|642913035|ref|XP_008201360.1| PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|270001925|gb|EEZ98372.1| hypothetical protein TcasGA2_TC000831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9H8 465 6.3e-45 Apoptotic protease-activating factor 1 OS=Danio rerio GN=apaf1 PE=2 SV=1 PF00931//PF02020 NB-ARC domain//eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515//GO:0043531 protein binding//ADP binding -- -- -- -- Cluster-8309.31452 BP_3 12.58 0.46 1597 270012861 EFA09309.1 929 2.0e-97 hypothetical protein TcasGA2_TC030652 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q80UG8 659 1.6e-67 Tubulin polyglutamylase TTLL4 OS=Mus musculus GN=Ttll4 PE=2 SV=3 PF03171//PF03133 2OG-Fe(II) oxygenase superfamily//Tubulin-tyrosine ligase family GO:0055114//GO:0006464 oxidation-reduction process//cellular protein modification process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31458 BP_3 76.12 3.60 1312 642933084 XP_008197253.1 1531 2.5e-167 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 1005 1.0e-107 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03171//PF03133 2OG-Fe(II) oxygenase superfamily//Tubulin-tyrosine ligase family GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31459 BP_3 195.35 14.55 939 478250603 ENN71095.1 798 1.8e-82 hypothetical protein YQE_12028, partial [Dendroctonus ponderosae] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 311 2.2e-27 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.31460 BP_3 16.20 0.34 2562 546673099 ERL84768.1 749 2.3e-76 hypothetical protein D910_02193 [Dendroctonus ponderosae] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 311 5.9e-27 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.31461 BP_3 191.05 2.43 4076 546673598 ERL85162.1 1169 7.4e-125 hypothetical protein D910_02584, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R5M3 279 4.8e-23 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31462 BP_3 82.01 1.74 2561 285403695 NP_001164137.1 1348 8.2e-146 Wnt6 protein precursor [Tribolium castaneum] -- -- -- -- -- K00445 WNT6 wingless-type MMTV integration site family, member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00445 Q9Y6F9 924 4.9e-98 Protein Wnt-6 OS=Homo sapiens GN=WNT6 PE=1 SV=2 PF00110 wnt family GO:0007275//GO:0016055//GO:0007165 multicellular organismal development//Wnt signaling pathway//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.31463 BP_3 132.99 2.89 2507 285403695 NP_001164137.1 1348 8.0e-146 Wnt6 protein precursor [Tribolium castaneum] -- -- -- -- -- K00445 WNT6 wingless-type MMTV integration site family, member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00445 Q9Y6F9 924 4.8e-98 Protein Wnt-6 OS=Homo sapiens GN=WNT6 PE=1 SV=2 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.31464 BP_3 116.00 11.76 767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31465 BP_3 879.69 14.72 3172 642928263 XP_001812997.2 1813 1.2e-199 PREDICTED: cyclin-T [Tribolium castaneum] -- -- -- -- -- K15188 CCNT cyclin T http://www.genome.jp/dbget-bin/www_bget?ko:K15188 O96433 749 1.2e-77 Cyclin-T OS=Drosophila melanogaster GN=CycT PE=1 SV=2 PF00528//PF02317 Binding-protein-dependent transport system inner membrane component//NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain GO:0055114//GO:0006810 oxidation-reduction process//transport GO:0016491//GO:0050662 oxidoreductase activity//coenzyme binding GO:0016020 membrane KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.31468 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31473 BP_3 852.44 7.02 6147 642935193 XP_008199686.1 2675 2.6e-299 PREDICTED: ATP-dependent RNA helicase abstrakt [Tribolium castaneum] 665786806 XM_008556015.1 412 0 PREDICTED: Microplitis demolitor ATP-dependent RNA helicase abstrakt (LOC103575994), mRNA K13116 DDX41, ABS ATP-dependent RNA helicase DDX41 http://www.genome.jp/dbget-bin/www_bget?ko:K13116 Q9V3C0 2220 6.2e-248 ATP-dependent RNA helicase abstrakt OS=Drosophila melanogaster GN=abs PE=1 SV=1 PF04851//PF00098//PF06862//PF01805//PF00096//PF06220//PF00270 Type III restriction enzyme, res subunit//Zinc knuckle//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//Surp module//Zinc finger, C2H2 type//U1 zinc finger//DEAD/DEAH box helicase GO:0006396 RNA processing GO:0008270//GO:0003676//GO:0046872//GO:0005524//GO:0003723//GO:0003677//GO:0016787 zinc ion binding//nucleic acid binding//metal ion binding//ATP binding//RNA binding//DNA binding//hydrolase activity GO:0005634 nucleus KOG0341 DEAD-box protein abstrakt Cluster-8309.31474 BP_3 5301.00 381.20 962 -- -- -- -- -- 826416851 XM_012667750.1 40 2.47183e-09 PREDICTED: Monomorium pharaonis tubulin beta chain (LOC105829097), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31475 BP_3 418.07 13.99 1732 91079210 XP_966588.1 982 1.5e-103 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [Tribolium castaneum]>gi|270004834|gb|EFA01282.1| hypothetical protein TcasGA2_TC002817 [Tribolium castaneum] 699239055 XM_002131725.3 75 1.57987e-28 PREDICTED: Ciona intestinalis NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (LOC100183052), mRNA K03936 NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03936 P23709 791 8.8e-83 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Bos taurus GN=NDUFS3 PE=1 SV=1 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit GO:0015992//GO:0055114//GO:0006814//GO:0006120//GO:0006744 proton transport//oxidation-reduction process//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- KOG1713 NADH-ubiquinone oxidoreductase, NDUFS3/30 kDa subunit Cluster-8309.31476 BP_3 383.00 12.25 1799 546686189 ERL95569.1 1395 2.0e-151 hypothetical protein D910_12830 [Dendroctonus ponderosae] -- -- -- -- -- K09881 AGK acylglycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09881 Q53H12 619 8.0e-63 Acylglycerol kinase, mitochondrial OS=Homo sapiens GN=AGK PE=1 SV=2 PF00781 Diacylglycerol kinase catalytic domain -- -- GO:0016301 kinase activity -- -- KOG4435 Predicted lipid kinase Cluster-8309.31478 BP_3 17.42 0.39 2447 270001858 EEZ98305.1 1631 1.2e-178 hypothetical protein TcasGA2_TC000758 [Tribolium castaneum] -- -- -- -- -- K13147 INTS10 integrator complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13147 Q6TNU3 462 1.8e-44 Integrator complex subunit 10 OS=Danio rerio GN=ints10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31479 BP_3 521.31 15.03 1963 91082963 XP_973727.1 1606 7.6e-176 PREDICTED: dnaJ homolog subfamily B member 11 [Tribolium castaneum] 820854133 XM_003695391.2 191 5.88848e-93 PREDICTED: Apis florea dnaJ homolog subfamily B member 11 (LOC100870508), mRNA K09517 DNAJB11 DnaJ homolog subfamily B member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09517 Q5RAJ6 1131 3.7e-122 DnaJ homolog subfamily B member 11 OS=Pongo abelii GN=DNAJB11 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.3148 BP_3 211.42 2.88 3824 642920186 XP_008192239.1 4929 0.0e+00 PREDICTED: lutropin-choriogonadotropic hormone receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K08399 LGR6 leucine-rich repeat-containing G protein-coupled receptor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08399 D4AC13 1110 2.0e-119 Leucine-rich repeat-containing G-protein coupled receptor 5 OS=Rattus norvegicus GN=Lgr5 PE=3 SV=1 PF00001//PF00560//PF13855 7 transmembrane receptor (rhodopsin family)//Leucine Rich Repeat//Leucine rich repeat GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.31482 BP_3 262.29 3.83 3589 642918856 XP_008191616.1 1737 8.9e-191 PREDICTED: pericentriolar material 1 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76329 142 3.3e-07 Interaptin OS=Dictyostelium discoideum GN=abpD PE=1 SV=1 PF01414//PF04434 Delta serrate ligand//SWIM zinc finger GO:0007154 cell communication GO:0008270 zinc ion binding GO:0016020 membrane -- -- Cluster-8309.31483 BP_3 97.00 2.41 2231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31484 BP_3 23.00 6.11 473 642913166 XP_008201418.1 283 4.7e-23 PREDICTED: 39S ribosomal protein L33, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02913 RP-L33, MRPL33, rpmG large subunit ribosomal protein L33 http://www.genome.jp/dbget-bin/www_bget?ko:K02913 Q7PYH1 243 8.4e-20 39S ribosomal protein L33, mitochondrial OS=Anopheles gambiae GN=mRpL33 PE=3 SV=2 PF00471 Ribosomal protein L33 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.31487 BP_3 77.45 0.68 5784 642921963 XP_008192963.1 2834 0.0e+00 PREDICTED: uncharacterized protein LOC658725 [Tribolium castaneum]>gi|270007382|gb|EFA03830.1| hypothetical protein TcasGA2_TC013946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.31488 BP_3 984.20 33.61 1703 91088443 XP_968621.1 1541 2.3e-168 PREDICTED: coiled-coil domain-containing protein 47 [Tribolium castaneum]>gi|270011745|gb|EFA08193.1| hypothetical protein TcasGA2_TC005820 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC50 931 5.0e-99 Coiled-coil domain-containing protein 47 OS=Bos taurus GN=CCDC47 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2357 Uncharacterized conserved protein Cluster-8309.31489 BP_3 370.82 11.97 1785 478251900 ENN72338.1 2230 3.0e-248 hypothetical protein YQE_10973, partial [Dendroctonus ponderosae]>gi|546680877|gb|ERL91063.1| hypothetical protein D910_08405 [Dendroctonus ponderosae] 170071688 XM_001869946.1 223 8.69425e-111 Culex quinquefasciatus dihydrolipoamide dehydrogenase, mRNA K00382 DLD, lpd, pdhD dihydrolipoamide dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00382 P09623 1847 3.2e-205 Dihydrolipoyl dehydrogenase, mitochondrial OS=Sus scrofa GN=DLD PE=1 SV=1 PF02852//PF07992//PF01494//PF00070 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0071949//GO:0016491 FAD binding//oxidoreductase activity -- -- KOG1335 Dihydrolipoamide dehydrogenase Cluster-8309.3149 BP_3 6.00 0.66 729 642920186 XP_008192239.1 201 2.3e-13 PREDICTED: lutropin-choriogonadotropic hormone receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31490 BP_3 783.47 47.31 1090 91077352 XP_975026.1 692 4.0e-70 PREDICTED: V-type proton ATPase 21 kDa proteolipid subunit [Tribolium castaneum]>gi|642913832|ref|XP_008201179.1| PREDICTED: V-type proton ATPase 21 kDa proteolipid subunit [Tribolium castaneum]>gi|270002761|gb|EEZ99208.1| VhaPPA1-1 [Tribolium castaneum] -- -- -- -- -- K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q91V37 478 1.1e-46 V-type proton ATPase 21 kDa proteolipid subunit OS=Mus musculus GN=Atp6v0b PE=1 SV=1 PF00137 ATP synthase subunit C GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.31493 BP_3 51.44 0.70 3819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04216 Protein involved in formate dehydrogenase formation -- -- -- -- GO:0005737 cytoplasm -- -- Cluster-8309.31494 BP_3 17.00 2.99 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31495 BP_3 15.01 0.32 2542 815805772 XP_012223637.1 245 6.4e-18 PREDICTED: 60S ribosomal protein L37 isoform X1 [Linepithema humile] 70909882 AM049128.1 84 2.31752e-33 Sphaerius sp. APV-2005 mRNA for ribosomal protein L37e (rpL37e gene) K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q962S7 240 1.0e-18 60S ribosomal protein L37 OS=Spodoptera frugiperda GN=RpL37 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3475 60S ribosomal protein L37 Cluster-8309.31496 BP_3 2.00 0.36 560 -- -- -- -- -- 768311756 CP010984.1 424 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence -- -- -- -- Q9Y7K0 179 2.6e-12 UPF0659 protein C216.03 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC216.03 PE=3 SV=1 PF01370 NAD dependent epimerase/dehydratase family -- -- GO:0050662//GO:0003824 coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.31497 BP_3 77.65 0.66 5971 642938278 XP_008192712.1 3281 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 958 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.3e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF12142//PF00069//PF07714 Polyphenol oxidase middle domain//Protein kinase domain//Protein tyrosine kinase GO:0006118//GO:0006570//GO:0055114//GO:0006468 obsolete electron transport//tyrosine metabolic process//oxidation-reduction process//protein phosphorylation GO:0005524//GO:0004672//GO:0004097 ATP binding//protein kinase activity//catechol oxidase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.31498 BP_3 6.01 0.60 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31499 BP_3 37.10 1.19 1794 554879053 XP_005949345.1 151 3.6e-07 PREDICTED: low-density lipoprotein receptor-related protein 2-like [Haplochromis burtoni] -- -- -- -- -- -- -- -- -- P98164 140 2.8e-07 Low-density lipoprotein receptor-related protein 2 OS=Homo sapiens GN=LRP2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.315 BP_3 1.00 0.41 408 573907447 XP_006641443.1 401 8.4e-37 PREDICTED: vacuolar protein sorting-associated protein 35-like [Lepisosteus oculatus] 768311757 CP010985.1 402 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence K18468 VPS35 vacuolar protein sorting-associated protein 35 http://www.genome.jp/dbget-bin/www_bget?ko:K18468 Q9EQH3 395 1.7e-37 Vacuolar protein sorting-associated protein 35 OS=Mus musculus GN=Vps35 PE=1 SV=1 PF03635 Vacuolar protein sorting-associated protein 35 GO:0015031//GO:0042147 protein transport//retrograde transport, endosome to Golgi GO:0008565 protein transporter activity GO:0030904 retromer complex KOG1107 Membrane coat complex Retromer, subunit VPS35 Cluster-8309.3150 BP_3 29.29 0.38 4053 642920186 XP_008192239.1 2753 1.6e-308 PREDICTED: lutropin-choriogonadotropic hormone receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K08399 LGR6 leucine-rich repeat-containing G protein-coupled receptor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08399 Q7ZTV5 766 1.6e-79 Follicle-stimulating hormone receptor OS=Cairina moschata GN=FSHR PE=2 SV=1 PF13855//PF00560//PF00001 Leucine rich repeat//Leucine Rich Repeat//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.31500 BP_3 198.00 14.09 969 91078296 XP_972110.1 751 5.2e-77 PREDICTED: presqualene diphosphate phosphatase [Tribolium castaneum]>gi|270003950|gb|EFA00398.1| hypothetical protein TcasGA2_TC003248 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TZ07 224 2.7e-17 Presqualene diphosphate phosphatase OS=Danio rerio GN=ppapdc2 PE=2 SV=1 PF01899 Na+/H+ ion antiporter subunit GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG4268 Uncharacterized conserved protein containing PAP2 domain Cluster-8309.31501 BP_3 363.30 18.41 1243 478259624 ENN79477.1 979 2.4e-103 hypothetical protein YQE_04121, partial [Dendroctonus ponderosae] -- -- -- -- -- K13982 DDX4, VASA probable ATP-dependent RNA helicase DDX4 http://www.genome.jp/dbget-bin/www_bget?ko:K13982 P09052 700 2.2e-72 ATP-dependent RNA helicase vasa, isoform A OS=Drosophila melanogaster GN=vas PE=1 SV=3 PF01297//PF06862 Zinc-uptake complex component A periplasmic//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 GO:0030001 metal ion transport GO:0046872 metal ion binding GO:0005634 nucleus KOG0335 ATP-dependent RNA helicase Cluster-8309.31502 BP_3 64.00 0.99 3400 91082195 XP_971684.1 1399 1.3e-151 PREDICTED: nipped-B-like protein B [Tribolium castaneum]>gi|270007443|gb|EFA03891.1| hypothetical protein TcasGA2_TC014015 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03176 MMPL family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.31503 BP_3 18.62 0.33 3013 332373358 AEE61820.1 1190 2.0e-127 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02737 PSMB5 20S proteasome subunit beta 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02737 Q54BC8 729 2.4e-75 Proteasome subunit beta type-5 OS=Dictyostelium discoideum GN=psmB5 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0175 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 Cluster-8309.31504 BP_3 624.88 9.95 3319 478256311 ENN76501.1 492 1.9e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31506 BP_3 98.69 1.33 3873 642921818 XP_008199331.1 2491 3.6e-278 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] 665798678 XM_008549002.1 56 1.30268e-17 PREDICTED: Microplitis demolitor vitamin K-dependent gamma-carboxylase (LOC103571031), transcript variant X3, mRNA K10106 GGCX vitamin K-dependent gamma-carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10106 Q9MYY3 1371 1.1e-149 Vitamin K-dependent gamma-carboxylase OS=Delphinapterus leucas GN=GGCX PE=2 SV=1 PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.3151 BP_3 64.99 0.92 3680 642920188 XP_008192240.1 4767 0.0e+00 PREDICTED: lutropin-choriogonadotropic hormone receptor isoform X2 [Tribolium castaneum] -- -- -- -- -- K08399 LGR6 leucine-rich repeat-containing G protein-coupled receptor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08399 D4AC13 964 1.6e-102 Leucine-rich repeat-containing G-protein coupled receptor 5 OS=Rattus norvegicus GN=Lgr5 PE=3 SV=1 PF13855//PF00560//PF00001 Leucine rich repeat//Leucine Rich Repeat//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.31510 BP_3 2.00 0.87 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31511 BP_3 494.00 44.15 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31512 BP_3 50.00 3.78 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31513 BP_3 2015.61 30.72 3454 642935527 XP_973346.2 2065 8.0e-229 PREDICTED: phosphoacetylglucosamine mutase [Tribolium castaneum] 629692694 XM_007813448.1 35 5.47588e-06 Metarhizium acridum CQMa 102 N-acetylglucosamine-phosphate mutase partial mRNA K01836 E5.4.2.3 phosphoacetylglucosamine mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01836 O95394 1416 5.9e-155 Phosphoacetylglucosamine mutase OS=Homo sapiens GN=PGM3 PE=1 SV=1 PF00408//PF02879//PF02878//PF02880//PF05698 Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Bacterial trigger factor protein (TF) C-terminus GO:0015031//GO:0005975//GO:0006457//GO:0071704 protein transport//carbohydrate metabolic process//protein folding//organic substance metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG2537 Phosphoglucomutase/phosphomannomutase Cluster-8309.31519 BP_3 739.88 4.58 8077 546673207 ERL84861.1 1263 1.8e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.2e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF04632//PF01066//PF05529//PF00437//PF07989//PF03193//PF00005//PF04548//PF02183//PF15458//PF17078//PF06156//PF04111//PF06005//PF01166//PF03824//PF00503 Fusaric acid resistance protein family//CDP-alcohol phosphatidyltransferase//B-cell receptor-associated protein 31-like//Type II/IV secretion system protein//Centrosomin N-terminal motif 1//Protein of unknown function, DUF258//ABC transporter//AIG1 family//Homeobox associated leucine zipper//Nineteen complex-related protein 2//SWI5-dependent HO expression protein 3//Protein of unknown function (DUF972)//Autophagy protein Apg6//Protein of unknown function (DUF904)//TSC-22/dip/bun family//High-affinity nickel-transport protein//G-protein alpha subunit GO:0000917//GO:0008654//GO:0043093//GO:0007165//GO:0006914//GO:0006886//GO:0006810//GO:0007186//GO:0000390//GO:0006355//GO:0015675//GO:0051028//GO:0048309//GO:0035444//GO:0006260 barrier septum assembly//phospholipid biosynthetic process//FtsZ-dependent cytokinesis//signal transduction//autophagy//intracellular protein transport//transport//G-protein coupled receptor signaling pathway//spliceosomal complex disassembly//regulation of transcription, DNA-templated//nickel cation transport//mRNA transport//endoplasmic reticulum inheritance//nickel cation transmembrane transport//DNA replication GO:0016780//GO:0015099//GO:0005525//GO:0004871//GO:0043565//GO:0046872//GO:0005524//GO:0031683//GO:0003924//GO:0019001//GO:0016887//GO:0003700 phosphotransferase activity, for other substituted phosphate groups//nickel cation transmembrane transporter activity//GTP binding//signal transducer activity//sequence-specific DNA binding//metal ion binding//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//guanyl nucleotide binding//ATPase activity//transcription factor activity, sequence-specific DNA binding GO:0005886//GO:0005783//GO:0016020//GO:0005815//GO:0016021//GO:0005737//GO:0071008//GO:0005667 plasma membrane//endoplasmic reticulum//membrane//microtubule organizing center//integral component of membrane//cytoplasm//U2-type post-mRNA release spliceosomal complex//transcription factor complex KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.3152 BP_3 329.86 1.91 8624 642911448 XP_008199427.1 3378 0.0e+00 PREDICTED: atrial natriuretic peptide-converting enzyme-like [Tribolium castaneum] 642911447 XM_008201205.1 584 0 PREDICTED: Tribolium castaneum atrial natriuretic peptide-converting enzyme-like (LOC661781), mRNA K09614 CORIN corin http://www.genome.jp/dbget-bin/www_bget?ko:K09614 P98073 535 2.1e-52 Enteropeptidase OS=Homo sapiens GN=TMPRSS15 PE=1 SV=3 PF01392//PF00057//PF00089//PF15494 Fz domain//Low-density lipoprotein receptor domain class A//Trypsin//Scavenger receptor cysteine-rich domain GO:0006508 proteolysis GO:0005515//GO:0004252 protein binding//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.31520 BP_3 192.44 1.18 8183 546673207 ERL84861.1 1263 1.9e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.2e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF07989//PF03193//PF00005//PF02183//PF04548//PF15458//PF17078//PF04632//PF01066//PF05529//PF00437//PF01166//PF03824//PF00503//PF04111//PF06156//PF06005 Centrosomin N-terminal motif 1//Protein of unknown function, DUF258//ABC transporter//Homeobox associated leucine zipper//AIG1 family//Nineteen complex-related protein 2//SWI5-dependent HO expression protein 3//Fusaric acid resistance protein family//CDP-alcohol phosphatidyltransferase//B-cell receptor-associated protein 31-like//Type II/IV secretion system protein//TSC-22/dip/bun family//High-affinity nickel-transport protein//G-protein alpha subunit//Autophagy protein Apg6//Protein of unknown function (DUF972)//Protein of unknown function (DUF904) GO:0007186//GO:0000390//GO:0006355//GO:0015675//GO:0007165//GO:0006886//GO:0006810//GO:0006914//GO:0000917//GO:0008654//GO:0043093//GO:0006260//GO:0035444//GO:0048309//GO:0051028 G-protein coupled receptor signaling pathway//spliceosomal complex disassembly//regulation of transcription, DNA-templated//nickel cation transport//signal transduction//intracellular protein transport//transport//autophagy//barrier septum assembly//phospholipid biosynthetic process//FtsZ-dependent cytokinesis//DNA replication//nickel cation transmembrane transport//endoplasmic reticulum inheritance//mRNA transport GO:0043565//GO:0004871//GO:0015099//GO:0005525//GO:0016780//GO:0019001//GO:0016887//GO:0003700//GO:0031683//GO:0005524//GO:0003924//GO:0046872 sequence-specific DNA binding//signal transducer activity//nickel cation transmembrane transporter activity//GTP binding//phosphotransferase activity, for other substituted phosphate groups//guanyl nucleotide binding//ATPase activity//transcription factor activity, sequence-specific DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//metal ion binding GO:0005737//GO:0005815//GO:0016021//GO:0016020//GO:0005886//GO:0005783//GO:0071008//GO:0005667 cytoplasm//microtubule organizing center//integral component of membrane//membrane//plasma membrane//endoplasmic reticulum//U2-type post-mRNA release spliceosomal complex//transcription factor complex KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.31521 BP_3 1322.71 19.18 3616 91093755 XP_969513.1 2176 1.1e-241 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270012977|gb|EFA09425.1| hypothetical protein TcasGA2_TC010636 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 O15254 1461 3.7e-160 Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens GN=ACOX3 PE=1 SV=2 PF01756//PF00107//PF07716//PF05139//PF00441//PF07544//PF02770 Acyl-CoA oxidase//Zinc-binding dehydrogenase//Basic region leucine zipper//Erythromycin esterase//Acyl-CoA dehydrogenase, C-terminal domain//RNA polymerase II transcription mediator complex subunit 9//Acyl-CoA dehydrogenase, middle domain GO:0006637//GO:0055114//GO:0006355//GO:0006118//GO:0006357//GO:0006635//GO:0046677//GO:0006631 acyl-CoA metabolic process//oxidation-reduction process//regulation of transcription, DNA-templated//obsolete electron transport//regulation of transcription from RNA polymerase II promoter//fatty acid beta-oxidation//response to antibiotic//fatty acid metabolic process GO:0003995//GO:0003700//GO:0016627//GO:0043565//GO:0001104//GO:0003997 acyl-CoA dehydrogenase activity//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//sequence-specific DNA binding//RNA polymerase II transcription cofactor activity//acyl-CoA oxidase activity GO:0005667//GO:0005777//GO:0016592 transcription factor complex//peroxisome//mediator complex KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.31522 BP_3 84.71 2.34 2034 642936925 XP_008194485.1 1059 2.1e-112 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X2 [Tribolium castaneum] -- -- -- -- -- K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 235 3.1e-18 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF00023//PF13606//PF03776//PF09494 Ankyrin repeat//Ankyrin repeat//Septum formation topological specificity factor MinE//Slx4 endonuclease GO:0006308//GO:0032955//GO:0051301//GO:0006260//GO:0006281 DNA catabolic process//regulation of barrier septum assembly//cell division//DNA replication//DNA repair GO:0005515//GO:0017108 protein binding//5'-flap endonuclease activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus -- -- Cluster-8309.31524 BP_3 677.00 6.93 4999 642921594 XP_008192439.1 1804 2.1e-198 PREDICTED: protein xmas-2 [Tribolium castaneum]>gi|270006333|gb|EFA02781.1| hypothetical protein TcasGA2_TC008518 [Tribolium castaneum] 170067749 XM_001868570.1 97 2.72155e-40 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q9U3V9 1089 7.1e-117 Protein xmas-2 OS=Drosophila melanogaster GN=xmas-2 PE=1 SV=3 PF09468 Ydr279p protein family (RNase H2 complex component) -- -- -- -- GO:0005634 nucleus KOG1860 Nuclear protein export factor Cluster-8309.31525 BP_3 855.77 29.56 1687 642918520 XP_008191507.1 692 6.3e-70 PREDICTED: uncharacterized protein CG1161 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNA4 351 9.0e-32 Uncharacterized protein CG1161 OS=Drosophila melanogaster GN=CG1161 PE=3 SV=1 PF01708//PF05434 Geminivirus putative movement protein//TMEM9 GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane KOG4007 Uncharacterized conserved protein Cluster-8309.31527 BP_3 62.16 0.50 6305 642924902 XP_008194090.1 1523 1.0e-165 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.65622e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 1.1e-114 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13833//PF10591//PF13405//PF13499//PF02022//PF00036//PF08332//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//Integrase Zinc binding domain//EF hand//Calcium/calmodulin dependent protein kinase II association domain//EF hand GO:0007165//GO:0016310//GO:0006468//GO:0009069 signal transduction//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005516//GO:0004683//GO:0005509//GO:0008270 calmodulin binding//calmodulin-dependent protein kinase activity//calcium ion binding//zinc ion binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.31528 BP_3 26.07 0.32 4220 189241229 XP_971878.2 771 1.1e-78 PREDICTED: DNA primase large subunit [Tribolium castaneum]>gi|270013987|gb|EFA10435.1| hypothetical protein TcasGA2_TC012678 [Tribolium castaneum] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 P33610 646 1.4e-65 DNA primase large subunit OS=Mus musculus GN=Prim2 PE=1 SV=1 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896 DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.3153 BP_3 120.15 0.66 9055 642911448 XP_008199427.1 3581 0.0e+00 PREDICTED: atrial natriuretic peptide-converting enzyme-like [Tribolium castaneum] 642911447 XM_008201205.1 584 0 PREDICTED: Tribolium castaneum atrial natriuretic peptide-converting enzyme-like (LOC661781), mRNA K09614 CORIN corin http://www.genome.jp/dbget-bin/www_bget?ko:K09614 P98073 535 2.2e-52 Enteropeptidase OS=Homo sapiens GN=TMPRSS15 PE=1 SV=3 PF00057//PF01392//PF00089//PF15494 Low-density lipoprotein receptor domain class A//Fz domain//Trypsin//Scavenger receptor cysteine-rich domain GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.31530 BP_3 1774.31 41.98 2329 189238821 XP_968538.2 947 2.3e-99 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|642927448|ref|XP_008195277.1| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|270010156|gb|EFA06604.1| hypothetical protein TcasGA2_TC009519 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 455 1.1e-43 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF07650//PF13184//PF13014//PF00013 KH domain//NusA-like KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.31532 BP_3 177.38 8.51 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31535 BP_3 872.24 7.85 5648 642913636 XP_008201097.1 848 1.7e-87 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum]>gi|270002053|gb|EEZ98500.1| hypothetical protein TcasGA2_TC001001 [Tribolium castaneum] 642913635 XM_008202875.1 61 3.16577e-20 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC661669), mRNA -- -- -- -- Q9W596 677 4.7e-69 Microtubule-associated protein futsch OS=Drosophila melanogaster GN=futsch PE=1 SV=4 PF05923//PF02187//PF01825 APC cysteine-rich region//Growth-Arrest-Specific Protein 2 Domain//GPCR proteolysis site, GPS, motif GO:0007050//GO:0016055 cell cycle arrest//Wnt signaling pathway -- -- GO:0016020 membrane -- -- Cluster-8309.31537 BP_3 209.00 11.86 1141 478263036 ENN81436.1 706 1.0e-71 hypothetical protein YQE_02129, partial [Dendroctonus ponderosae] -- -- -- -- -- K13154 ZCRB1 U11/U12 small nuclear ribonucleoprotein 31 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13154 Q6DJI9 532 6.2e-53 Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Xenopus laevis GN=zcrb1 PE=2 SV=1 PF00076//PF16367//PF00098 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG0118 FOG: RRM domain Cluster-8309.31538 BP_3 412.77 6.23 3484 642931800 XP_008196735.1 1799 5.6e-198 PREDICTED: probable tRNA (guanine(26)-N(2))-dimethyltransferase [Tribolium castaneum] 805826840 XM_012297893.1 36 1.53586e-06 PREDICTED: Megachile rotundata probable tRNA (guanine(26)-N(2))-dimethyltransferase (LOC105664233), mRNA K00555 TRMT1, trm1 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00555 Q9VK89 1497 2.4e-164 Probable tRNA (guanine(26)-N(2))-dimethyltransferase OS=Drosophila melanogaster GN=CG6388 PE=2 SV=1 PF02005//PF05958//PF03602//PF05175 N2,N2-dimethylguanosine tRNA methyltransferase//tRNA (Uracil-5-)-methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain GO:0008033//GO:0006396//GO:0009451//GO:0031167 tRNA processing//RNA processing//RNA modification//rRNA methylation GO:0004809//GO:0008168//GO:0008173//GO:0003723 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//RNA methyltransferase activity//RNA binding -- -- KOG1253 tRNA methyltransferase Cluster-8309.31539 BP_3 35.00 8.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31540 BP_3 1237.91 26.01 2586 642928778 XP_008195558.1 2110 3.6e-234 PREDICTED: hexosaminidase 1 isoform X2 [Tribolium castaneum] 462295813 APGK01052604.1 77 1.83594e-29 Dendroctonus ponderosae Seq01052614, whole genome shotgun sequence K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P49010 1696 1.5e-187 Chitooligosaccharidolytic beta-N-acetylglucosaminidase OS=Bombyx mori PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.31541 BP_3 1245.83 14.68 4382 91095065 XP_972609.1 4037 0.0e+00 PREDICTED: IQ motif and SEC7 domain-containing protein 1 isoform X2 [Tribolium castaneum]>gi|270014755|gb|EFA11203.1| hypothetical protein TcasGA2_TC005167 [Tribolium castaneum] 641661643 XM_001945108.3 182 1.33636e-87 PREDICTED: Acyrthosiphon pisum IQ motif and SEC7 domain-containing protein 1 (LOC100162626), transcript variant X2, mRNA K12495 IQSEC IQ motif and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12495 Q6DN90 1206 1.7e-130 IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens GN=IQSEC1 PE=1 SV=1 PF01369//PF04977//PF00612 Sec7 domain//Septum formation initiator//IQ calmodulin-binding motif GO:0007049//GO:0043087//GO:0032012 cell cycle//regulation of GTPase activity//regulation of ARF protein signal transduction GO:0005515//GO:0005086//GO:0005543 protein binding//ARF guanyl-nucleotide exchange factor activity//phospholipid binding GO:0005622 intracellular KOG0931 Predicted guanine nucleotide exchange factor, contains Sec7 domain Cluster-8309.31542 BP_3 349.28 9.37 2089 189241787 XP_969759.2 2313 8.4e-258 PREDICTED: cell division cycle protein 16 homolog [Tribolium castaneum] -- -- -- -- -- K03353 APC6, CDC16 anaphase-promoting complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03353 Q13042 1075 1.2e-115 Cell division cycle protein 16 homolog OS=Homo sapiens GN=CDC16 PE=1 SV=2 PF04097//PF13181//PF13174//PF04049//PF13374//PF00515//PF13371//PF13414//PF13176 Nup93/Nic96//Tetratricopeptide repeat//Tetratricopeptide repeat//Anaphase promoting complex subunit 8 / Cdc23//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006810//GO:0030071 transport//regulation of mitotic metaphase/anaphase transition GO:0005515 protein binding GO:0005680//GO:0005643 anaphase-promoting complex//nuclear pore KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit Cluster-8309.31544 BP_3 8.46 1.16 644 642932806 XP_008196991.1 535 3.8e-52 PREDICTED: myosin heavy chain, non-muscle isoform X2 [Tribolium castaneum] -- -- -- -- -- K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q61879 419 4.5e-40 Myosin-10 OS=Mus musculus GN=Myh10 PE=1 SV=2 PF00063//PF02736 Myosin head (motor domain)//Myosin N-terminal SH3-like domain -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.31545 BP_3 5.00 0.81 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31551 BP_3 816.02 7.33 5657 478252773 ENN73166.1 3703 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1864 1.1e-206 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31552 BP_3 2300.53 13.82 8318 478252773 ENN73166.1 3703 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1864 1.6e-206 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF16965//PF02209 Ceramide synthase regulator//Villin headpiece domain GO:0007010//GO:0006874 cytoskeleton organization//cellular calcium ion homeostasis GO:0003779//GO:0030234 actin binding//enzyme regulator activity GO:0030176 integral component of endoplasmic reticulum membrane KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31554 BP_3 67.28 0.35 9444 478252773 ENN73166.1 3484 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1831 1.2e-202 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31555 BP_3 1993.72 20.10 5072 478252773 ENN73166.1 3672 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1864 9.8e-207 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31556 BP_3 3113.84 40.28 4018 270297188 NP_001161909.1 1041 5.1e-110 cuticular protein analogous to peritrophins 3-A2 precursor [Tribolium castaneum]>gi|268309020|gb|ACY95476.1| cuticular protein analogous to peritrophins 3-A2 [Tribolium castaneum]>gi|270000883|gb|EEZ97330.1| hypothetical protein TcasGA2_TC011141 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76217 139 8.2e-07 Peritrophin-1 OS=Anopheles gambiae GN=Aper1 PE=2 SV=2 PF06941//PF01607 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)//Chitin binding Peritrophin-A domain GO:0009264//GO:0006030 deoxyribonucleotide catabolic process//chitin metabolic process GO:0008253//GO:0008061 5'-nucleotidase activity//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.31558 BP_3 2661.88 19.42 6898 270008035 EFA04483.1 2949 0.0e+00 hypothetical protein TcasGA2_TC014788 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q9ES28 909 7.3e-96 Rho guanine nucleotide exchange factor 7 OS=Mus musculus GN=Arhgef7 PE=1 SV=2 PF10280//PF00621//PF14604//PF00018 Mediator complex protein//RhoGEF domain//Variant SH3 domain//SH3 domain GO:0043087//GO:0035023//GO:0006357 regulation of GTPase activity//regulation of Rho protein signal transduction//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0005089//GO:0001104 protein binding//Rho guanyl-nucleotide exchange factor activity//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2070 Guanine nucleotide exchange factor Cluster-8309.31559 BP_3 2347.74 16.50 7148 642927132 XP_008195151.1 2005 1.5e-221 PREDICTED: far upstream element-binding protein 1 isoform X2 [Tribolium castaneum] 755783784 XM_006939555.2 43 4.06725e-10 PREDICTED: Felis catus far upstream element (FUSE) binding protein 3 (FUBP3), transcript variant X2, mRNA K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 1.8e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF13014//PF13184//PF00013//PF07650//PF10192 KH domain//NusA-like KH domain//KH domain//KH domain//Rhodopsin-like GPCR transmembrane domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.31560 BP_3 18.00 13.68 350 642925135 XP_008194182.1 228 8.3e-17 PREDICTED: rho guanine nucleotide exchange factor 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31562 BP_3 914.00 18.74 2643 91081187 XP_975598.1 1544 1.6e-168 PREDICTED: GAS2-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43903 349 2.4e-31 Growth arrest-specific protein 2 OS=Homo sapiens GN=GAS2 PE=1 SV=1 PF00307//PF02187 Calponin homology (CH) domain//Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.31564 BP_3 227.94 1.06 10640 642926389 XP_008194905.1 4856 0.0e+00 PREDICTED: citron Rho-interacting kinase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14578 2071 2.0e-230 Citron Rho-interacting kinase OS=Homo sapiens GN=CIT PE=1 SV=2 PF00069//PF07714//PF00130//PF13851//PF00827//PF15367//PF01326//PF00433 Protein kinase domain//Protein tyrosine kinase//Phorbol esters/diacylglycerol binding domain (C1 domain)//Growth-arrest specific micro-tubule binding//Ribosomal L15//Calcium-binding and spermatid-specific protein 1//Pyruvate phosphate dikinase, PEP/pyruvate binding domain//Protein kinase C terminal domain GO:0016310//GO:0048870//GO:0006412//GO:0007283//GO:0035556//GO:0042254//GO:0006468//GO:0009069 phosphorylation//cell motility//translation//spermatogenesis//intracellular signal transduction//ribosome biogenesis//protein phosphorylation//serine family amino acid metabolic process GO:0005509//GO:0004672//GO:0016301//GO:0003735//GO:0004674//GO:0005524 calcium ion binding//protein kinase activity//kinase activity//structural constituent of ribosome//protein serine/threonine kinase activity//ATP binding GO:0005840//GO:0031514 ribosome//motile cilium KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.31566 BP_3 161.32 17.08 747 642920229 XP_008192257.1 440 4.6e-41 PREDICTED: 60S ribosomal protein L10a isoform X1 [Tribolium castaneum] 315115352 HQ424705.1 140 4.88501e-65 Euphydryas aurinia ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 403 3.7e-38 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00468 Ribosomal protein L34 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1570 60S ribosomal protein L10A Cluster-8309.31568 BP_3 762.00 10.22 3886 189240214 XP_001807190.1 826 4.2e-85 PREDICTED: uncharacterized protein LOC100142448 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01445//PF08826//PF01166 Viral small hydrophobic protein//DMPK coiled coil domain like//TSC-22/dip/bun family GO:0006355//GO:0016310//GO:0009069//GO:0006468 regulation of transcription, DNA-templated//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004674//GO:0003700//GO:0005524 protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//ATP binding GO:0016020//GO:0005667 membrane//transcription factor complex -- -- Cluster-8309.3157 BP_3 257.64 3.38 3963 642910681 XP_008200058.1 923 2.4e-96 PREDICTED: Kv channel-interacting protein 4-like isoform X2 [Tribolium castaneum] 642910680 XM_008201836.1 229 9.01025e-114 PREDICTED: Tribolium castaneum Kv channel-interacting protein 4-like (LOC657688), transcript variant X2, mRNA -- -- -- -- Q99MG9 580 5.9e-58 Kv channel-interacting protein 4 OS=Rattus norvegicus GN=Kcnip4 PE=1 SV=1 PF12763//PF10591//PF13833//PF13405//PF03802//PF13499//PF13202//PF13762//PF00036 Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase//EF-hand domain pair//EF hand//Mitochondrial splicing apparatus component//EF hand GO:0051191//GO:0000372//GO:0007165 prosthetic group biosynthetic process//Group I intron splicing//signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0030529//GO:0005578 intracellular ribonucleoprotein complex//proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.31570 BP_3 703.00 37.85 1187 478254407 ENN74659.1 543 8.4e-53 hypothetical protein YQE_08776, partial [Dendroctonus ponderosae]>gi|546682348|gb|ERL92296.1| hypothetical protein D910_09613 [Dendroctonus ponderosae] -- -- -- -- -- K07554 ATPeF0S, ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s http://www.genome.jp/dbget-bin/www_bget?ko:K07554 P22027 343 5.3e-31 ATP synthase subunit s, mitochondrial OS=Bos taurus GN=ATP5S PE=1 SV=2 PF10152 Predicted coiled-coil domain-containing protein (DUF2360) -- -- -- -- GO:0071203 WASH complex KOG3864 Uncharacterized conserved protein Cluster-8309.31571 BP_3 21.83 0.48 2476 498940560 XP_004521425.1 2552 1.9e-285 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [Ceratitis capitata] 827557300 XM_012694468.1 426 0 PREDICTED: Bombyx mori putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (LOC101743469), mRNA K12813 DHX16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 http://www.genome.jp/dbget-bin/www_bget?ko:K12813 Q767K6 2076 1.2e-231 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Sus scrofa GN=DHX16 PE=3 SV=1 PF00448//PF07652//PF00270//PF00437//PF04408//PF14532 SRP54-type protein, GTPase domain//Flavivirus DEAD domain//DEAD/DEAH box helicase//Type II/IV secretion system protein//Helicase associated domain (HA2)//Sigma-54 interaction domain GO:0006355//GO:0019079//GO:0006614//GO:0006810 regulation of transcription, DNA-templated//viral genome replication//SRP-dependent cotranslational protein targeting to membrane//transport GO:0003676//GO:0005525//GO:0005524//GO:0004386//GO:0008134//GO:0008026 nucleic acid binding//GTP binding//ATP binding//helicase activity//transcription factor binding//ATP-dependent helicase activity GO:0005667 transcription factor complex KOG0923 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.31572 BP_3 342.07 6.45 2849 642934752 XP_008197796.1 1257 3.2e-135 PREDICTED: transmembrane protein 129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IJ33 730 1.7e-75 E3 ubiquitin-protein ligase TM129 OS=Xenopus tropicalis GN=tmem129 PE=2 SV=1 PF00181//PF05203 Ribosomal Proteins L2, RNA binding domain//Hom_end-associated Hint GO:0042254//GO:0006412//GO:0030908 ribosome biogenesis//translation//protein splicing GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.31574 BP_3 495.70 13.47 2066 642937320 XP_008198786.1 1306 4.9e-141 PREDICTED: venom carboxylesterase-6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 970 1.8e-103 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.31575 BP_3 395.50 2.14 9200 642911702 XP_008200708.1 3335 0.0e+00 PREDICTED: histone-lysine N-methyltransferase trithorax [Tribolium castaneum] -- -- -- -- -- K09186 MLL1 histone-lysine N-methyltransferase MLL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09186 Q24742 1435 9.8e-157 Histone-lysine N-methyltransferase trithorax OS=Drosophila virilis GN=trx PE=3 SV=1 PF00439//PF05965//PF00856//PF05001//PF05964//PF06221//PF00628 Bromodomain//F/Y rich C-terminus//SET domain//RNA polymerase Rpb1 C-terminal repeat//F/Y-rich N-terminus//Putative zinc finger motif, C2HC5-type//PHD-finger GO:0006355//GO:0006366 regulation of transcription, DNA-templated//transcription from RNA polymerase II promoter GO:0008270//GO:0003677//GO:0005515 zinc ion binding//DNA binding//protein binding GO:0005634//GO:0005665 nucleus//DNA-directed RNA polymerase II, core complex KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.31576 BP_3 1772.75 17.45 5189 642919375 XP_008191845.1 3545 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 831 6.1e-87 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF02480//PF01325//PF13895//PF00069//PF07714 Alphaherpesvirus glycoprotein E//Iron dependent repressor, N-terminal DNA binding domain//Immunoglobulin domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0003677//GO:0005524 protein kinase activity//protein binding//DNA binding//ATP binding GO:0016020 membrane -- -- Cluster-8309.31577 BP_3 10.00 0.61 1076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00387 Phosphatidylinositol-specific phospholipase C, Y domain GO:0035556//GO:0006629//GO:0007165//GO:0046339//GO:0009395 intracellular signal transduction//lipid metabolic process//signal transduction//diacylglycerol metabolic process//phospholipid catabolic process GO:0004435 phosphatidylinositol phospholipase C activity -- -- -- -- Cluster-8309.31578 BP_3 520.00 81.56 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31579 BP_3 20.11 0.58 1973 264667463 ACY71317.1 234 9.4e-17 ribosomal protein L22 [Chrysomela tremula] 751203339 XM_011176882.1 46 2.384e-12 PREDICTED: Solenopsis invicta 60S ribosomal protein L22-like (LOC105207442), mRNA -- -- -- -- P50887 131 3.4e-06 60S ribosomal protein L22 OS=Drosophila melanogaster GN=RpL22 PE=1 SV=2 PF01776 Ribosomal L22e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.31580 BP_3 5.00 0.42 861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31583 BP_3 2184.95 30.12 3788 478260934 ENN80551.1 251 1.9e-18 hypothetical protein YQE_03030, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09807//PF02234 Elongation complex protein 6//Cyclin-dependent kinase inhibitor GO:0045859//GO:0007050 regulation of protein kinase activity//cell cycle arrest GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634//GO:0033588 nucleus//Elongator holoenzyme complex -- -- Cluster-8309.31586 BP_3 668.79 10.77 3285 642921092 XP_008192688.1 1903 4.6e-210 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q9VDR1 538 3.6e-53 Mediator of RNA polymerase II transcription subunit 25 OS=Drosophila melanogaster GN=MED25 PE=2 SV=1 PF00643//PF09398 B-box zinc finger//FOP N terminal dimerisation domain GO:0034453 microtubule anchoring GO:0008270 zinc ion binding GO:0005622//GO:0005815 intracellular//microtubule organizing center -- -- Cluster-8309.31588 BP_3 13.38 0.59 1390 270007898 EFA04346.1 1133 3.8e-121 hypothetical protein TcasGA2_TC014642 [Tribolium castaneum] -- -- -- -- -- K16600 TTLL2 tubulin polyglutamylase TTLL2 http://www.genome.jp/dbget-bin/www_bget?ko:K16600 Q9BWV7 553 2.8e-55 Probable tubulin polyglutamylase TTLL2 OS=Homo sapiens GN=TTLL2 PE=5 SV=3 PF03133//PF01430 Tubulin-tyrosine ligase family//Hsp33 protein GO:0006457//GO:0006464 protein folding//cellular protein modification process GO:0051082 unfolded protein binding GO:0005737 cytoplasm KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31589 BP_3 700.62 32.18 1341 189237761 XP_001812872.1 1398 6.8e-152 PREDICTED: probable tubulin polyglutamylase TTLL2 [Tribolium castaneum] -- -- -- -- -- K16600 TTLL2 tubulin polyglutamylase TTLL2 http://www.genome.jp/dbget-bin/www_bget?ko:K16600 Q9BWV7 553 2.7e-55 Probable tubulin polyglutamylase TTLL2 OS=Homo sapiens GN=TTLL2 PE=5 SV=3 PF01430//PF03133 Hsp33 protein//Tubulin-tyrosine ligase family GO:0006464//GO:0006457 cellular protein modification process//protein folding GO:0051082 unfolded protein binding GO:0005737 cytoplasm KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31591 BP_3 3.76 0.40 750 189237761 XP_001812872.1 756 1.1e-77 PREDICTED: probable tubulin polyglutamylase TTLL2 [Tribolium castaneum] -- -- -- -- -- K16600 TTLL2 tubulin polyglutamylase TTLL2 http://www.genome.jp/dbget-bin/www_bget?ko:K16600 Q9BWV7 291 3.6e-25 Probable tubulin polyglutamylase TTLL2 OS=Homo sapiens GN=TTLL2 PE=5 SV=3 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- -- -- Cluster-8309.31595 BP_3 24.46 0.67 2051 91079642 XP_968121.1 1930 2.1e-213 PREDICTED: vacuolar protein sorting-associated protein 4B [Tribolium castaneum]>gi|270004475|gb|EFA00923.1| hypothetical protein TcasGA2_TC003829 [Tribolium castaneum] 346710885 AK385938.1 85 5.18158e-34 Bombyx mori mRNA, clone: fphe14F12 K12196 VPS4 vacuolar protein-sorting-associated protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12196 Q0VD48 1601 1.2e-176 Vacuolar protein sorting-associated protein 4B OS=Bos taurus GN=VPS4B PE=2 SV=1 PF13176//PF00004//PF13414//PF00515 Tetratricopeptide repeat//ATPase family associated with various cellular activities (AAA)//TPR repeat//Tetratricopeptide repeat -- -- GO:0005524//GO:0005515//GO:0017111 ATP binding//protein binding//nucleoside-triphosphatase activity -- -- KOG0739 AAA+-type ATPase Cluster-8309.31596 BP_3 638.84 17.26 2076 91082807 XP_968134.1 1136 2.5e-121 PREDICTED: general transcription factor IIF subunit 2 [Tribolium castaneum]>gi|270007102|gb|EFA03550.1| hypothetical protein TcasGA2_TC013555 [Tribolium castaneum] 755881816 XM_005185870.2 95 1.44825e-39 PREDICTED: Musca domestica general transcription factor IIF subunit 2 (LOC101901202), mRNA K03139 TFIIF2, GTF2F2, TFG2 transcription initiation factor TFIIF subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03139 P41900 871 5.6e-92 General transcription factor IIF subunit 2 OS=Drosophila melanogaster GN=TfIIFbeta PE=2 SV=2 PF02270 Transcription initiation factor IIF, beta subunit GO:0006367//GO:0006366 transcription initiation from RNA polymerase II promoter//transcription from RNA polymerase II promoter GO:0005524//GO:0003824 ATP binding//catalytic activity GO:0005674 transcription factor TFIIF complex KOG2905 Transcription initiation factor IIF, small subunit (RAP30) Cluster-8309.31599 BP_3 171.48 2.51 3590 242018392 XP_002429661.1 645 3.8e-64 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 529 4.4e-52 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.316 BP_3 3.00 0.39 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31601 BP_3 58.24 0.41 7148 649572237 NP_001280538.1 2012 2.3e-222 5-hydroxytryptamine receptor [Tribolium castaneum]>gi|510960964|gb|AGN56420.1| serotonin receptor type 1 [Tribolium castaneum] 195584787 XM_002082150.1 80 1.09929e-30 Drosophila simulans GD11428 (Dsim\GD11428), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25190 1208 1.6e-130 5-hydroxytryptamine receptor OS=Heliothis virescens PE=2 SV=1 PF00974//PF00001 Rhabdovirus spike glycoprotein//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.31602 BP_3 81.07 0.57 7115 649572237 NP_001280538.1 2012 2.3e-222 5-hydroxytryptamine receptor [Tribolium castaneum]>gi|510960964|gb|AGN56420.1| serotonin receptor type 1 [Tribolium castaneum] 195584787 XM_002082150.1 80 1.09419e-30 Drosophila simulans GD11428 (Dsim\GD11428), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25190 1208 1.6e-130 5-hydroxytryptamine receptor OS=Heliothis virescens PE=2 SV=1 PF00001//PF00974 7 transmembrane receptor (rhodopsin family)//Rhabdovirus spike glycoprotein GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0019031 integral component of membrane//viral envelope KOG3656 FOG: 7 transmembrane receptor Cluster-8309.31603 BP_3 29.77 0.41 3801 189235428 XP_001812612.1 2394 6.2e-267 PREDICTED: importin-4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEX9 771 4.0e-80 Importin-4 OS=Homo sapiens GN=IPO4 PE=1 SV=2 PF03810//PF02985//PF07836 Importin-beta N-terminal domain//HEAT repeat//DmpG-like communication domain GO:0006886//GO:0019439 intracellular protein transport//aromatic compound catabolic process GO:0005515//GO:0016833//GO:0008536 protein binding//oxo-acid-lyase activity//Ran GTPase binding -- -- KOG2171 Karyopherin (importin) beta 3 Cluster-8309.31605 BP_3 217.38 5.54 2184 642937984 XP_008199157.1 325 2.9e-27 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.31607 BP_3 402.67 16.66 1457 642921101 XP_975194.2 1033 1.6e-109 PREDICTED: something about silencing protein 10 [Tribolium castaneum] -- -- -- -- -- K14767 UTP3, SAS10 U3 small nucleolar RNA-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14767 Q9I7W5 561 3.5e-56 Something about silencing protein 10 OS=Drosophila melanogaster GN=Sas10 PE=1 SV=2 PF03165 MH1 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3118 Disrupter of silencing SAS10 Cluster-8309.31608 BP_3 595.17 9.95 3175 642924616 XP_008194365.1 1944 7.8e-215 PREDICTED: uncharacterized protein LOC663601 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 4.4e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.3161 BP_3 11.00 0.32 1954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31612 BP_3 11.05 0.44 1490 642925464 XP_008194565.1 397 8.9e-36 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome -- -- Cluster-8309.31616 BP_3 211.48 22.00 755 642925667 XP_008194662.1 866 1.9e-90 PREDICTED: uncharacterized protein LOC663019 isoform X2 [Tribolium castaneum]>gi|270008899|gb|EFA05347.1| hypothetical protein TcasGA2_TC015511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31618 BP_3 36.06 2.09 1123 642925667 XP_008194662.1 838 4.9e-87 PREDICTED: uncharacterized protein LOC663019 isoform X2 [Tribolium castaneum]>gi|270008899|gb|EFA05347.1| hypothetical protein TcasGA2_TC015511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31620 BP_3 122.09 0.56 10864 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.61558e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF00069//PF09162//PF07714//PF04043//PF01059 Protein kinase domain//Tap, RNA-binding//Protein tyrosine kinase//Plant invertase/pectin methylesterase inhibitor//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006120//GO:0006468//GO:0006406//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//protein phosphorylation//mRNA export from nucleus//oxidation-reduction process GO:0003723//GO:0005524//GO:0004857//GO:0004672 RNA binding//ATP binding//enzyme inhibitor activity//protein kinase activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG3625 Alpha amylase Cluster-8309.31621 BP_3 5978.31 32.06 9280 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.37922e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF09162//PF04043 Tap, RNA-binding//Plant invertase/pectin methylesterase inhibitor GO:0006406 mRNA export from nucleus GO:0003723//GO:0004857 RNA binding//enzyme inhibitor activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG3625 Alpha amylase Cluster-8309.31622 BP_3 3399.85 58.21 3107 264667361 ACY71266.1 379 2.3e-33 ribosomal protein S25 [Chrysomela tremula] 525546292 KC480143.1 89 4.71549e-36 Dolomedes mizhoanus isolate DM-283 putative 40S ribosomal protein S25 gene, complete cds K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q962Q5 344 1.1e-30 40S ribosomal protein S25 OS=Spodoptera frugiperda GN=RpS25 PE=3 SV=1 PF15050//PF06632//PF09302 SCIMP protein//DNA double-strand break repair and V(D)J recombination protein XRCC4//XLF-Cernunnos, XRcc4-like factor, NHEJ component GO:0006302//GO:0006310 double-strand break repair//DNA recombination GO:0003677 DNA binding GO:0097197//GO:0016021//GO:0005634//GO:0001772 tetraspanin-enriched microdomain//integral component of membrane//nucleus//immunological synapse KOG1767 40S ribosomal protein S25 Cluster-8309.31624 BP_3 178.90 3.53 2737 478249731 ENN70239.1 482 2.3e-45 hypothetical protein YQE_13023, partial [Dendroctonus ponderosae]>gi|546677413|gb|ERL88250.1| hypothetical protein D910_05638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y639 172 8.3e-11 Neuroplastin OS=Homo sapiens GN=NPTN PE=1 SV=2 PF13895//PF08120 Immunoglobulin domain//Tamulustoxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870//GO:0005515 potassium channel inhibitor activity//protein binding GO:0005576 extracellular region -- -- Cluster-8309.31625 BP_3 11.00 6.04 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31626 BP_3 1363.63 9.79 7003 150170685 NP_001092812.1 1789 1.6e-196 methoprene-tolerant [Tribolium castaneum]>gi|149384881|gb|ABR25244.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- K13125 NOSIP nitric oxide synthase-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K13125 Q9VWV8 928 4.6e-98 Nitric oxide synthase-interacting protein homolog OS=Drosophila melanogaster GN=CG6179 PE=3 SV=1 PF00989//PF04564//PF00010//PF11789//PF08447 PAS fold//U-box domain//Helix-loop-helix DNA-binding domain//Zinc-finger of the MIZ type in Nse subunit//PAS fold GO:0016567//GO:0007165//GO:0006355 protein ubiquitination//signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0004842//GO:0046983//GO:0003677//GO:0003700//GO:0004871//GO:0008270 protein binding//ubiquitin-protein transferase activity//protein dimerization activity//DNA binding//transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm KOG3039 Uncharacterized conserved protein Cluster-8309.31629 BP_3 51.29 0.36 7145 150170685 NP_001092812.1 1789 1.7e-196 methoprene-tolerant [Tribolium castaneum]>gi|149384881|gb|ABR25244.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- K13125 NOSIP nitric oxide synthase-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K13125 Q9VWV8 589 9.6e-59 Nitric oxide synthase-interacting protein homolog OS=Drosophila melanogaster GN=CG6179 PE=3 SV=1 PF00010//PF11789//PF08447//PF04564//PF00989 Helix-loop-helix DNA-binding domain//Zinc-finger of the MIZ type in Nse subunit//PAS fold//U-box domain//PAS fold GO:0006355//GO:0016567//GO:0007165 regulation of transcription, DNA-templated//protein ubiquitination//signal transduction GO:0003700//GO:0004871//GO:0008270//GO:0005515//GO:0046983//GO:0004842//GO:0003677 transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding//protein binding//protein dimerization activity//ubiquitin-protein transferase activity//DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG3039 Uncharacterized conserved protein Cluster-8309.31631 BP_3 1.00 2.80 283 642915337 XP_008190578.1 345 1.8e-30 PREDICTED: fibrinogen C domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 O95841 255 2.0e-21 Angiopoietin-related protein 1 OS=Homo sapiens GN=ANGPTL1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31632 BP_3 649.24 10.01 3418 332373100 AEE61691.1 1619 4.1e-177 unknown [Dendroctonus ponderosae] 632980128 XM_007908668.1 273 2.69392e-138 PREDICTED: Callorhinchus milii casein kinase 2, alpha 1 polypeptide (csnk2a1), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 3.1e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.31633 BP_3 691.90 10.10 3593 332373100 AEE61691.1 1682 2.1e-184 unknown [Dendroctonus ponderosae] 642911564 XM_008201254.1 402 0 PREDICTED: Tribolium castaneum casein kinase II subunit alpha-like (LOC660746), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 3.2e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.31634 BP_3 272.43 6.35 2358 91089723 XP_975024.1 1451 8.6e-158 PREDICTED: ATPase family AAA domain-containing protein 1-B [Tribolium castaneum]>gi|270011311|gb|EFA07759.1| hypothetical protein TcasGA2_TC005313 [Tribolium castaneum] 768421023 XM_011553001.1 182 7.14525e-88 PREDICTED: Plutella xylostella ATPase family AAA domain-containing protein 1-A (LOC105383005), mRNA -- -- -- -- Q503W7 1051 8.5e-113 ATPase family AAA domain-containing protein 1-B OS=Danio rerio GN=atad1b PE=2 SV=2 PF00910//PF02562//PF06414//PF02367//PF00004//PF07724//PF01695//PF07728//PF05496//PF06068//PF00158 RNA helicase//PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//Sigma-54 interaction domain GO:0006310//GO:0002949//GO:0006355//GO:0006281 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair GO:0003724//GO:0009378//GO:0017111//GO:0003723//GO:0003678//GO:0016887//GO:0016301//GO:0005524//GO:0008134 RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//RNA binding//DNA helicase activity//ATPase activity//kinase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0737 AAA+-type ATPase Cluster-8309.31635 BP_3 312.42 2.70 5876 642938770 XP_008199881.1 1708 3.4e-187 PREDICTED: protein transport protein Sec16B-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15027 945 4.1e-100 Protein transport protein Sec16A OS=Homo sapiens GN=SEC16A PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1913 Regucalcin gene promoter region-related protein (RGPR) Cluster-8309.31638 BP_3 17.04 0.37 2500 642914452 XP_008201682.1 1236 7.7e-133 PREDICTED: GRAM domain-containing protein 1B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3KR37 322 3.1e-28 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31639 BP_3 356.71 5.78 3267 646710326 KDR15870.1 2260 1.8e-251 Dual serine/threonine and tyrosine protein kinase, partial [Zootermopsis nevadensis] -- -- -- -- -- K16288 RIPK5, DSTYK receptor-interacting serine/threonine-protein kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16288 Q1L6Q1 2010 7.4e-224 Dual serine/threonine and tyrosine protein kinase OS=Apis mellifera GN=DSTYK PE=2 SV=1 PF07714//PF06293//PF01442//PF00069//PF04614 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Apolipoprotein A1/A4/E domain//Protein kinase domain//Pex19 protein family GO:0042157//GO:0006869//GO:0006468 lipoprotein metabolic process//lipid transport//protein phosphorylation GO:0008289//GO:0005524//GO:0016773//GO:0004672 lipid binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0005777//GO:0016020//GO:0005576 peroxisome//membrane//extracellular region -- -- Cluster-8309.31641 BP_3 5.74 0.67 704 642914953 XP_008190456.1 267 5.0e-21 PREDICTED: uncharacterized protein LOC661624 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31642 BP_3 235.13 2.58 4686 -- -- -- -- -- 86515329 NM_001039401.1 63 2.02778e-21 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.31643 BP_3 89.53 2.23 2224 642927566 XP_972340.2 565 4.4e-55 PREDICTED: 40S ribosomal protein S12 [Tribolium castaneum] -- -- -- -- -- K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P80455 426 2.4e-40 40S ribosomal protein S12 OS=Drosophila melanogaster GN=RpS12 PE=1 SV=2 PF02065 Melibiase GO:0006012//GO:0046486//GO:0005975//GO:0001575 galactose metabolic process//glycerolipid metabolic process//carbohydrate metabolic process//globoside metabolic process GO:0004557 alpha-galactosidase activity -- -- KOG3406 40S ribosomal protein S12 Cluster-8309.31645 BP_3 92.24 1.52 3209 149588751 NP_001092296.1 2699 2.3e-302 fused lobes [Tribolium castaneum]>gi|642928772|ref|XP_008195555.1| PREDICTED: fused lobes isoform X1 [Tribolium castaneum]>gi|148611482|gb|ABQ95985.1| beta-N-acetylglucosaminidase FDL [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 1351 1.9e-147 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975//GO:0006027//GO:0001575//GO:0006040 carbohydrate metabolic process//glycosaminoglycan catabolic process//globoside metabolic process//amino sugar metabolic process GO:0004563//GO:0004553//GO:0043169 beta-N-acetylhexosaminidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.31646 BP_3 10278.56 79.99 6485 546685142 ERL94669.1 5047 0.0e+00 hypothetical protein D910_11944 [Dendroctonus ponderosae] 665804316 XM_008552072.1 92 2.12738e-37 PREDICTED: Microplitis demolitor neuroglian (LOC103573142), mRNA -- -- -- -- P20241 3670 0.0e+00 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF16656//PF02979//PF00041//PF13895//PF01108 Purple acid Phosphatase, N-terminal domain//Nitrile hydratase, alpha chain//Fibronectin type III domain//Immunoglobulin domain//Tissue factor GO:0019497//GO:0006771//GO:0006807 hexachlorocyclohexane metabolic process//riboflavin metabolic process//nitrogen compound metabolic process GO:0046914//GO:0003824//GO:0005515//GO:0003993//GO:0046872 transition metal ion binding//catalytic activity//protein binding//acid phosphatase activity//metal ion binding -- -- KOG3513 Neural cell adhesion molecule L1 Cluster-8309.31649 BP_3 2381.30 33.01 3769 270002548 EEZ98995.1 917 1.1e-95 hypothetical protein TcasGA2_TC004856 [Tribolium castaneum] 482684012 XM_004444488.1 108 1.57132e-46 Drosophila pseudoobscura pseudoobscura GA30269, transcript variant G (Dpse\GA30269), partial mRNA K17338 REEP1_2_3_4 receptor expression-enhancing protein 1/2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17338 Q4KMI4 510 7.3e-50 Receptor expression-enhancing protein 2 OS=Danio rerio GN=reep2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.31650 BP_3 27.49 0.41 3487 270002548 EEZ98995.1 220 7.0e-15 hypothetical protein TcasGA2_TC004856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31653 BP_3 631.45 15.19 2296 645001540 XP_008209577.1 493 1.0e-46 PREDICTED: uncharacterized protein LOC100119670 isoform X2 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q0P5B9 259 5.7e-21 Ankyrin repeat domain-containing protein 39 OS=Bos taurus GN=ANKRD39 PE=2 SV=1 PF00023//PF13606//PF06399 Ankyrin repeat//Ankyrin repeat//GTP cyclohydrolase I feedback regulatory protein (GFRP) GO:0009890 negative regulation of biosynthetic process GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.31656 BP_3 70.00 1.71 2266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31658 BP_3 1458.80 47.79 1763 478250970 ENN71454.1 937 2.6e-98 hypothetical protein YQE_11872, partial [Dendroctonus ponderosae]>gi|546682661|gb|ERL92573.1| hypothetical protein D910_09886 [Dendroctonus ponderosae] -- -- -- -- -- K15143 MED30 mediator of RNA polymerase II transcription subunit 30 http://www.genome.jp/dbget-bin/www_bget?ko:K15143 Q172Y1 539 1.5e-53 Mediator of RNA polymerase II transcription subunit 30 OS=Aedes aegypti GN=MED30 PE=3 SV=1 PF04546//PF03153 Sigma-70, non-essential region//Transcription factor IIA, alpha/beta subunit GO:0006367//GO:0006352//GO:0006355 transcription initiation from RNA polymerase II promoter//DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0016987//GO:0003677 transcription factor activity, sequence-specific DNA binding//sigma factor activity//DNA binding GO:0005672//GO:0005667 transcription factor TFIIA complex//transcription factor complex -- -- Cluster-8309.31660 BP_3 25.53 0.93 1614 91094373 XP_970761.1 1477 5.7e-161 PREDICTED: COP9 signalosome complex subunit 3 [Tribolium castaneum]>gi|270014914|gb|EFA11362.1| hypothetical protein TcasGA2_TC011519 [Tribolium castaneum] -- -- -- -- -- K12177 COPS3, CSN3 COP9 signalosome complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12177 Q6P2U9 1059 6.9e-114 COP9 signalosome complex subunit 3 OS=Danio rerio GN=cops3 PE=2 SV=1 PF01399//PF03791 PCI domain//KNOX2 domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus KOG2582 COP9 signalosome, subunit CSN3 Cluster-8309.31662 BP_3 210.99 1.23 8554 642911061 XP_008200558.1 3598 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2982 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00813//PF00520 FliP family//Ion transport protein GO:0006811//GO:0009306//GO:0055085 ion transport//protein secretion//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.31663 BP_3 17.00 20.44 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11057 Cortexin of kidney -- -- -- -- GO:0031224 intrinsic component of membrane -- -- Cluster-8309.31665 BP_3 96.00 7.25 930 189237799 XP_001814012.1 437 1.3e-40 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 35A [Tribolium castaneum]>gi|270008127|gb|EFA04575.1| PNR-like protein [Tribolium castaneum] -- -- -- -- -- K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MVS5 256 5.1e-21 Polypeptide N-acetylgalactosaminyltransferase 35A OS=Drosophila melanogaster GN=Pgant35A PE=1 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus -- -- Cluster-8309.31666 BP_3 35.65 1.00 2003 478262459 ENN81130.1 869 2.2e-90 hypothetical protein YQE_02498, partial [Dendroctonus ponderosae]>gi|546672773|gb|ERL84529.1| hypothetical protein D910_01959 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T8L8 489 1.1e-47 Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Drosophila melanogaster GN=Alg10 PE=2 SV=1 PF04922 DIE2/ALG10 family GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0005789 endoplasmic reticulum membrane KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator Cluster-8309.31667 BP_3 679.96 20.39 1899 478262459 ENN81130.1 1176 5.3e-126 hypothetical protein YQE_02498, partial [Dendroctonus ponderosae]>gi|546672773|gb|ERL84529.1| hypothetical protein D910_01959 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T8L8 664 5.1e-68 Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Drosophila melanogaster GN=Alg10 PE=2 SV=1 PF04922 DIE2/ALG10 family GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0005789 endoplasmic reticulum membrane KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator Cluster-8309.31670 BP_3 622.62 9.17 3564 270011486 EFA07934.1 1655 2.9e-181 hypothetical protein TcasGA2_TC005515 [Tribolium castaneum] 755973707 XM_011308799.1 131 2.43279e-59 PREDICTED: Fopius arisanus dual specificity mitogen-activated protein kinase kinase 4-like (LOC105268902), mRNA K04430 MAP2K4, MKK4 mitogen-activated protein kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04430 P47809 1129 1.2e-121 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 PF07714//PF00069//PF04196 Protein tyrosine kinase//Protein kinase domain//Bunyavirus RNA dependent RNA polymerase GO:0006468//GO:0006144//GO:0006351//GO:0019079 protein phosphorylation//purine nucleobase metabolic process//transcription, DNA-templated//viral genome replication GO:0004672//GO:0003968//GO:0005524 protein kinase activity//RNA-directed RNA polymerase activity//ATP binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.31671 BP_3 317.00 12.79 1486 642935823 XP_008198190.1 1395 1.7e-151 PREDICTED: serine--pyruvate aminotransferase, mitochondrial [Tribolium castaneum]>gi|270013276|gb|EFA09724.1| hypothetical protein TcasGA2_TC011857 [Tribolium castaneum] -- -- -- -- -- K00830 AGXT alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00830 P31029 1051 5.4e-113 Serine--pyruvate aminotransferase, mitochondrial OS=Callithrix jacchus GN=AGXT PE=2 SV=1 PF01053//PF00282//PF04083 Cys/Met metabolism PLP-dependent enzyme//Pyridoxal-dependent decarboxylase conserved domain//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0019752//GO:0008152 lipid metabolic process//carboxylic acid metabolic process//metabolic process GO:0030170//GO:0003824//GO:0016831 pyridoxal phosphate binding//catalytic activity//carboxy-lyase activity -- -- KOG2862 Alanine-glyoxylate aminotransferase AGT1 Cluster-8309.31673 BP_3 326.81 6.68 2650 270014262 EFA10710.1 1378 2.8e-149 domino [Tribolium castaneum] 760445496 XM_011401515.1 99 1.10888e-41 Auxenochlorella protothecoides Helicase swr1 partial mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 667 3.2e-68 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.31675 BP_3 1876.18 11.25 8329 642930614 XP_008199194.1 1174 4.0e-125 PREDICTED: protein winged eye isoform X1 [Tribolium castaneum]>gi|642930616|ref|XP_967104.2| PREDICTED: protein winged eye isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3LHL9 631 1.5e-63 Protein winged eye OS=Drosophila melanogaster GN=wge PE=1 SV=1 PF13181//PF01426 Tetratricopeptide repeat//BAH domain -- -- GO:0005515//GO:0003682 protein binding//chromatin binding GO:0000785 chromatin -- -- Cluster-8309.31677 BP_3 1883.46 14.17 6700 642922229 XP_008193071.1 1543 5.2e-168 PREDICTED: thiamine transporter 2-like [Tribolium castaneum]>gi|270007226|gb|EFA03674.1| hypothetical protein TcasGA2_TC013776 [Tribolium castaneum] 642922228 XM_008194849.1 161 9.66499e-76 PREDICTED: Tribolium castaneum thiamine transporter 2-like (LOC661148), mRNA K14610 SLC19A2_3, THTR solute carrier family 19 (thiamine transporter), member 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14610 Q22931 693 7.9e-71 Folate-like transporter 3 OS=Caenorhabditis elegans GN=folt-3 PE=3 SV=3 PF01770//PF00639//PF13145//PF01384 Reduced folate carrier//PPIC-type PPIASE domain//PPIC-type PPIASE domain//Phosphate transporter family GO:0006817//GO:0006810 phosphate ion transport//transport GO:0008518//GO:0016853//GO:0005542//GO:0005315 reduced folate carrier activity//isomerase activity//folic acid binding//inorganic phosphate transmembrane transporter activity GO:0016020 membrane KOG3810 Micronutrient transporters (folate transporter family) Cluster-8309.31678 BP_3 1797.00 49.49 2042 642925653 XP_008194657.1 238 3.3e-17 PREDICTED: uncharacterized protein LOC662907 [Tribolium castaneum]>gi|270008896|gb|EFA05344.1| hypothetical protein TcasGA2_TC015508 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31681 BP_3 1224.78 22.44 2923 332376234 AEE63257.1 1256 4.3e-135 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02867 RP-L11, MRPL11, rplK large subunit ribosomal protein L11 http://www.genome.jp/dbget-bin/www_bget?ko:K02867 Q9VFJ2 460 3.6e-44 39S ribosomal protein L11, mitochondrial OS=Drosophila melanogaster GN=mRpL11 PE=1 SV=1 PF00298//PF01064//PF00106 Ribosomal protein L11, RNA binding domain//Activin types I and II receptor domain//short chain dehydrogenase GO:0006412//GO:0016310//GO:0009069//GO:0008152//GO:0007178//GO:0042254 translation//phosphorylation//serine family amino acid metabolic process//metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway//ribosome biogenesis GO:0016491//GO:0004675//GO:0003735 oxidoreductase activity//transmembrane receptor protein serine/threonine kinase activity//structural constituent of ribosome GO:0016020//GO:0005840 membrane//ribosome KOG3257 Mitochondrial/chloroplast ribosomal protein L11 Cluster-8309.31682 BP_3 18.00 11.17 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31683 BP_3 1281.78 14.61 4519 642932410 XP_008197100.1 2437 7.6e-272 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AK53 362 1.3e-32 Espin OS=Homo sapiens GN=ESPN PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31684 BP_3 2216.13 40.92 2902 642923207 XP_969908.2 1738 5.5e-191 PREDICTED: dnaJ homolog subfamily C member 7 [Tribolium castaneum] -- -- -- -- -- K09527 DNAJC7 DnaJ homolog subfamily C member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09527 Q99615 1231 1.4e-133 DnaJ homolog subfamily C member 7 OS=Homo sapiens GN=DNAJC7 PE=1 SV=2 PF13174//PF13181//PF14863//PF06061//PF04196//PF13176//PF13414//PF13374//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Alkyl sulfatase dimerisation//Baculoviridae ME53//Bunyavirus RNA dependent RNA polymerase//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019079//GO:0006351//GO:0006144 viral genome replication//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0046983//GO:0005515//GO:0008270//GO:0003968 DNA binding//protein dimerization activity//protein binding//zinc ion binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG0550 Molecular chaperone (DnaJ superfamily) Cluster-8309.31685 BP_3 2.00 0.44 512 167444206 ABZ80664.1 379 3.7e-34 c-type lysozyme [Sitophilus zeamais] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 P12067 290 3.2e-25 Lysozyme C-1 OS=Sus scrofa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31687 BP_3 38.03 0.47 4183 270003819 EFA00267.1 170 5.3e-09 hypothetical protein TcasGA2_TC003100 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 147 1.0e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31688 BP_3 724.82 76.23 750 332374164 AEE62223.1 605 3.4e-60 unknown [Dendroctonus ponderosae] 821464696 XM_003759701.2 149 4.87098e-70 PREDICTED: Sarcophilus harrisii transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant X2, mRNA K03872 TCEB1 transcription elongation factor B, polypeptide 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03872 Q2KII4 552 2.0e-55 Transcription elongation factor B polypeptide 1 OS=Bos taurus GN=TCEB1 PE=3 SV=1 PF03931 Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process -- -- -- -- KOG3473 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin C Cluster-8309.31689 BP_3 167.32 1.57 5442 642912602 XP_008200928.1 1127 7.3e-120 PREDICTED: poly(A) RNA polymerase gld-2 homolog A-like [Tribolium castaneum]>gi|270002400|gb|EEZ98847.1| hypothetical protein TcasGA2_TC004457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW4 846 1.2e-88 ER membrane protein complex subunit 3 OS=Danio rerio GN=emc3 PE=2 SV=1 PF01956//PF06596//PF01909 Integral membrane protein DUF106//Photosystem II reaction centre X protein (PsbX)//Nucleotidyltransferase domain GO:0015979 photosynthesis GO:0016779 nucleotidyltransferase activity GO:0009523//GO:0016020 photosystem II//membrane KOG3188 Uncharacterized conserved protein Cluster-8309.31694 BP_3 1476.01 10.64 6979 91091256 XP_968850.1 1918 1.8e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.6e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF04117//PF00180//PF01398 Mpv17 / PMP22 family//Isocitrate/isopropylmalate dehydrogenase//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0006099//GO:0055114//GO:0006102//GO:0006749//GO:0019643 tricarboxylic acid cycle//oxidation-reduction process//isocitrate metabolic process//glutathione metabolic process//reductive tricarboxylic acid cycle GO:0000287//GO:0004450//GO:0016616//GO:0051287//GO:0005515 magnesium ion binding//isocitrate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//protein binding GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.31695 BP_3 3.00 0.53 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00895 ATP synthase protein 8 GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.31699 BP_3 8.00 3.01 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.317 BP_3 2.00 0.71 427 270017192 EFA13638.1 209 1.6e-14 hypothetical protein TcasGA2_TC005207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3170 BP_3 2.08 1.22 371 270003038 EEZ99485.1 382 1.2e-34 hypothetical protein TcasGA2_TC000060 [Tribolium castaneum] -- -- -- -- -- K00791 miaA, TRIT1 tRNA dimethylallyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00791 Q9H3H1 274 1.7e-23 tRNA dimethylallyltransferase, mitochondrial OS=Homo sapiens GN=TRIT1 PE=1 SV=1 PF01715 IPP transferase GO:0008033 tRNA processing -- -- -- -- KOG1384 tRNA delta(2)-isopentenylpyrophosphate transferase Cluster-8309.31701 BP_3 40.41 0.46 4545 642916252 XP_008190947.1 1220 1.0e-130 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15811 617 3.5e-62 Intersectin-1 OS=Homo sapiens GN=ITSN1 PE=1 SV=3 PF13181//PF00621 Tetratricopeptide repeat//RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.31702 BP_3 294.37 23.68 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31704 BP_3 501.00 30.40 1086 91086169 XP_970456.1 653 1.3e-65 PREDICTED: nucleolysin TIAR [Tribolium castaneum]>gi|270010230|gb|EFA06678.1| hypothetical protein TcasGA2_TC009608 [Tribolium castaneum] 759044574 XM_011332906.1 67 2.74327e-24 PREDICTED: Cerapachys biroi nucleolysin TIAR (LOC105275801), mRNA K13201 TIA1, TIAL1 nucleolysin TIA-1/TIAR http://www.genome.jp/dbget-bin/www_bget?ko:K13201 P31483 418 9.8e-40 Nucleolysin TIA-1 isoform p40 OS=Homo sapiens GN=TIA1 PE=1 SV=3 PF04995//PF08777//PF00076 Heme exporter protein D (CcmD)//RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0017004//GO:0015886 cytochrome complex assembly//heme transport GO:0003723//GO:0000166//GO:0003676 RNA binding//nucleotide binding//nucleic acid binding GO:0016021 integral component of membrane KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily) Cluster-8309.31705 BP_3 21.69 0.32 3586 577754854 AHH86056.1 1979 7.8e-219 glycoside hydrolase family 31 [Phaedon cochleariae] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 875 3.3e-92 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055//PF01607 Glycosyl hydrolases family 31//Chitin binding Peritrophin-A domain GO:0006030//GO:0005975 chitin metabolic process//carbohydrate metabolic process GO:0004553//GO:0008061 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding GO:0005576 extracellular region KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.31707 BP_3 4.00 0.71 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31713 BP_3 42.24 0.33 6527 546682046 ERL92032.1 1889 3.9e-208 hypothetical protein D910_09354, partial [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.35404e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.8e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF12317//PF03598//PF06784//PF01435//PF03650//PF00400 Intraflagellar transport complex B protein 46 C terminal//CO dehydrogenase/acetyl-CoA synthase complex beta subunit//Uncharacterised protein family (UPF0240)//Peptidase family M48//Uncharacterised protein family (UPF0041)//WD domain, G-beta repeat GO:0006084//GO:0015947//GO:0006850//GO:0032981//GO:0006508//GO:0042073 acetyl-CoA metabolic process//methane metabolic process//mitochondrial pyruvate transport//mitochondrial respiratory chain complex I assembly//proteolysis//intraciliary transport GO:0004222//GO:0005515//GO:0018492 metalloendopeptidase activity//protein binding//carbon-monoxide dehydrogenase (acceptor) activity GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.31714 BP_3 3.00 0.31 758 102939 390 2.9e-35 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P20825 334 3.8e-30 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31716 BP_3 238.50 6.32 2110 642915291 XP_008190557.1 1179 2.7e-126 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 605 4.0e-61 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.31718 BP_3 24.42 0.49 2712 728416984 AIY68330.1 1206 2.5e-129 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 580 4.0e-58 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.31719 BP_3 39.60 1.68 1428 478254827 ENN75063.1 680 1.3e-68 hypothetical protein YQE_08376, partial [Dendroctonus ponderosae] -- -- -- -- -- K15700 RNF146 E3 ubiquitin-protein ligase RNF146 http://www.genome.jp/dbget-bin/www_bget?ko:K15700 Q2PFU6 451 1.9e-43 E3 ubiquitin-protein ligase RNF146 OS=Macaca fascicularis GN=RNF146 PE=2 SV=1 PF14634//PF12678//PF00097//PF16685//PF13639 zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//zinc RING finger of MSL2//Ring finger domain -- -- GO:0061630//GO:0046872//GO:0005515//GO:0008270 ubiquitin protein ligase activity//metal ion binding//protein binding//zinc ion binding -- -- KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein Cluster-8309.31721 BP_3 39.88 0.73 2940 478259203 ENN79109.1 488 4.9e-46 hypothetical protein YQE_04432, partial [Dendroctonus ponderosae] -- -- -- -- -- K11187 PRDX5 peroxiredoxin 5, atypical 2-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11187 Q24491 318 1.1e-27 RNA-binding protein Rsf1 OS=Drosophila melanogaster GN=Rsf1 PE=1 SV=1 PF01848//PF00076//PF16367//PF08534//PF00578 Hok/gef family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Redoxin//AhpC/TSA family GO:0055114 oxidation-reduction process GO:0016209//GO:0003676//GO:0016491 antioxidant activity//nucleic acid binding//oxidoreductase activity GO:0016020 membrane KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin Cluster-8309.31722 BP_3 1259.45 13.75 4705 91084835 XP_966560.1 1369 5.5e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 6.7e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00892//PF13895//PF00114//PF06027//PF08449//PF04142//PF00893 EamA-like transporter family//Immunoglobulin domain//Pilin (bacterial filament)//Solute carrier family 35//UAA transporter family//Nucleotide-sugar transporter//Small Multidrug Resistance protein GO:0055085//GO:0006810//GO:0007155//GO:0008643 transmembrane transport//transport//cell adhesion//carbohydrate transport GO:0005351//GO:0005515 sugar:proton symporter activity//protein binding GO:0016021//GO:0009289//GO:0016020//GO:0000139 integral component of membrane//pilus//membrane//Golgi membrane KOG3912 Predicted integral membrane protein Cluster-8309.31723 BP_3 465.95 2.73 8510 642914685 XP_008190314.1 3692 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum] 695158202 XM_009508869.1 44 1.34744e-10 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08941 1375 8.3e-150 Proto-oncogene tyrosine-protein kinase ROS OS=Gallus gallus GN=ROS1 PE=1 SV=3 PF16656//PF00041//PF00069//PF07714 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0019497//GO:0006771 protein phosphorylation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0046872//GO:0003993 protein binding//ATP binding//protein kinase activity//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-8309.31724 BP_3 103.67 2.71 2137 91076522 XP_973518.1 1440 1.5e-156 PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|642912580|ref|XP_008200918.1| PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|270002610|gb|EEZ99057.1| hypothetical protein TcasGA2_TC004932 [Tribolium castaneum] 669193686 KF516645.1 38 7.24036e-08 Paracyclopina nana programmed cell death protein 4 mRNA, partial cds K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 606 3.1e-61 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.31725 BP_3 5069.30 166.19 1762 91076522 XP_973518.1 1440 1.2e-156 PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|642912580|ref|XP_008200918.1| PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|270002610|gb|EEZ99057.1| hypothetical protein TcasGA2_TC004932 [Tribolium castaneum] 669193686 KF516645.1 38 5.94867e-08 Paracyclopina nana programmed cell death protein 4 mRNA, partial cds K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 606 2.5e-61 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.31726 BP_3 203.71 2.71 3921 91088785 XP_967679.1 5125 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 1A [Tribolium castaneum]>gi|270011628|gb|EFA08076.1| hypothetical protein TcasGA2_TC005672 [Tribolium castaneum] 700253021 KM397468.1 42 7.99456e-10 Dioscorea oppositifolia structural maintenance of chromosomes protein 1 mRNA, partial cds K06636 SMC1 structural maintenance of chromosome 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06636 Q9CU62 2985 0.0e+00 Structural maintenance of chromosomes protein 1A OS=Mus musculus GN=Smc1a PE=1 SV=4 PF06470//PF13304//PF02984//PF04513 SMC proteins Flexible Hinge Domain//AAA domain, putative AbiEii toxin, Type IV TA system//Cyclin, C-terminal domain//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0030261//GO:0007062//GO:0006310//GO:0006281//GO:0051276 chromosome condensation//sister chromatid cohesion//DNA recombination//DNA repair//chromosome organization GO:0005198//GO:0005515//GO:0005524 structural molecule activity//protein binding//ATP binding GO:0005694//GO:0019031//GO:0019028//GO:0005634 chromosome//viral envelope//viral capsid//nucleus KOG0018 Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin, subunit SMC1) Cluster-8309.31728 BP_3 305.91 14.05 1341 156547143 XP_001603315.1 923 8.2e-97 PREDICTED: etoposide-induced protein 2.4 homolog [Nasonia vitripennis] -- -- -- -- -- K10134 EI24 etoposide-induced 2.4 mRNA http://www.genome.jp/dbget-bin/www_bget?ko:K10134 Q08DE5 659 1.4e-67 Etoposide-induced protein 2.4 homolog OS=Bos taurus GN=EI24 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3966 p53-mediated apoptosis protein EI24/PIG8 Cluster-8309.31729 BP_3 533.98 27.40 1231 91078580 XP_971846.1 727 4.0e-74 PREDICTED: UDP-N-acetylglucosamine transferase subunit ALG14 homolog [Tribolium castaneum]>gi|270004042|gb|EFA00490.1| hypothetical protein TcasGA2_TC003350 [Tribolium castaneum] -- -- -- -- -- K07441 ALG14 beta-1,4-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07441 Q9D081 457 3.3e-44 UDP-N-acetylglucosamine transferase subunit ALG14 homolog OS=Mus musculus GN=Alg14 PE=2 SV=1 PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0000775//GO:0005634 chromosome, centromeric region//nucleus KOG3339 Predicted glycosyltransferase Cluster-8309.31732 BP_3 88.32 1.63 2910 91078706 XP_971901.1 1904 3.1e-210 PREDICTED: putative RNA exonuclease NEF-sp [Tribolium castaneum]>gi|270003754|gb|EFA00202.1| hypothetical protein TcasGA2_TC003027 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q4R9F7 466 7.2e-45 Putative RNA exonuclease NEF-sp OS=Macaca fascicularis GN=QtsA-10054 PE=2 SV=1 -- -- -- -- GO:0003676//GO:0004527 nucleic acid binding//exonuclease activity GO:0005622 intracellular KOG2248 3'-5' exonuclease Cluster-8309.31733 BP_3 578.71 10.41 2970 91078706 XP_971901.1 1958 1.7e-216 PREDICTED: putative RNA exonuclease NEF-sp [Tribolium castaneum]>gi|270003754|gb|EFA00202.1| hypothetical protein TcasGA2_TC003027 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q4R9F7 466 7.3e-45 Putative RNA exonuclease NEF-sp OS=Macaca fascicularis GN=QtsA-10054 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2248 3'-5' exonuclease Cluster-8309.31736 BP_3 1474.69 10.94 6789 642929749 XP_008195960.1 2170 1.0e-240 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] 242020070 XM_002430435.1 38 2.32427e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05887//PF05433//PF03067//PF09172 Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain//Chitin binding domain//Domain of unknown function (DUF1943) GO:0006869 lipid transport GO:0005319 lipid transporter activity GO:0016020//GO:0019867//GO:0019028 membrane//outer membrane//viral capsid -- -- Cluster-8309.31737 BP_3 483.27 7.55 3378 91078826 XP_971080.1 2362 2.8e-263 PREDICTED: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [Tribolium castaneum]>gi|270003721|gb|EFA00169.1| hypothetical protein TcasGA2_TC002991 [Tribolium castaneum] 347970839 XM_308110.5 56 1.13463e-17 Anopheles gambiae str. PEST AGAP003884-PA (AgaP_AGAP003884) mRNA, complete cds K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 Q9UKM7 1389 7.8e-152 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Homo sapiens GN=MAN1B1 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0016020 membrane KOG2431 1, 2-alpha-mannosidase Cluster-8309.31740 BP_3 188.26 2.81 3516 189240719 XP_974316.2 757 3.8e-77 PREDICTED: TBC1 domain family member 9, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z1A9 220 2.9e-16 TBC1 domain family member 8 OS=Mus musculus GN=Tbc1d8 PE=2 SV=2 PF01213//PF10637 Adenylate cyclase associated (CAP) N terminal//Oxoglutarate and iron-dependent oxygenase degradation C-term GO:0055114//GO:0007010 oxidation-reduction process//cytoskeleton organization GO:0005506//GO:0003779//GO:0031418//GO:0016706 iron ion binding//actin binding//L-ascorbic acid binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.31743 BP_3 91.94 1.39 3472 546679558 ERL90006.1 570 1.8e-55 hypothetical protein D910_07364 [Dendroctonus ponderosae] 194753683 XM_001959104.1 36 1.53052e-06 Drosophila ananassae GF12210 (Dana\GF12210), mRNA K08283 COL4A3BP collagen type IV alpha-3-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08283 Q9GKI7 272 2.7e-22 Collagen type IV alpha-3-binding protein OS=Bos taurus GN=COL4A3BP PE=2 SV=1 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG1739 Serine/threonine protein kinase GPBP Cluster-8309.31744 BP_3 45.83 2.47 1186 270004586 EFA01034.1 632 4.0e-63 hypothetical protein TcasGA2_TC003950 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q4V348 548 9.1e-55 Zinc finger protein 658B OS=Homo sapiens GN=ZNF658B PE=2 SV=1 PF02892//PF13912//PF16622//PF00096//PF13465 BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.31745 BP_3 2108.45 16.23 6553 642914575 XP_971897.2 4166 0.0e+00 PREDICTED: insulin-degrading enzyme [Tribolium castaneum] -- -- -- -- -- K01408 IDE, ide insulysin http://www.genome.jp/dbget-bin/www_bget?ko:K01408 Q24K02 2825 0.0e+00 Insulin-degrading enzyme OS=Bos taurus GN=IDE PE=2 SV=1 PF14560 Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.31746 BP_3 1.01 0.39 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31747 BP_3 64.01 3.52 1168 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31749 BP_3 7.99 1.38 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3175 BP_3 9.00 0.38 1422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31750 BP_3 3203.27 144.26 1362 91079082 XP_975256.1 821 5.6e-85 PREDICTED: translocon-associated protein subunit alpha [Tribolium castaneum]>gi|270004205|gb|EFA00653.1| hypothetical protein TcasGA2_TC003529 [Tribolium castaneum] -- -- -- -- -- K13249 SSR1 translocon-associated protein subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13249 Q9CY50 444 1.2e-42 Translocon-associated protein subunit alpha OS=Mus musculus GN=Ssr1 PE=1 SV=1 PF03896 Translocon-associated protein (TRAP), alpha subunit -- -- -- -- GO:0005783//GO:0005789 endoplasmic reticulum//endoplasmic reticulum membrane KOG1631 Translocon-associated complex TRAP, alpha subunit Cluster-8309.31751 BP_3 132.81 5.04 1561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.31752 BP_3 70.45 0.95 3872 189240740 XP_968238.2 2467 2.2e-275 PREDICTED: phospholipase A-2-activating protein [Tribolium castaneum] -- -- -- -- -- K14018 PLAA, DOA1, UFD3 phospholipase A-2-activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K14018 Q9Y263 1082 3.5e-116 Phospholipase A-2-activating protein OS=Homo sapiens GN=PLAA PE=1 SV=2 PF00400//PF05676 WD domain, G-beta repeat//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GO:0006120//GO:0015992//GO:0006744//GO:0006814//GO:0006118 mitochondrial electron transport, NADH to ubiquinone//proton transport//ubiquinone biosynthetic process//sodium ion transport//obsolete electron transport GO:0003954//GO:0005515//GO:0008137 NADH dehydrogenase activity//protein binding//NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion KOG0301 Phospholipase A2-activating protein (contains WD40 repeats) Cluster-8309.31753 BP_3 16.06 0.39 2274 642925776 XP_008201712.1 1713 3.4e-188 PREDICTED: solute carrier family 26 member 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q9BEG8 641 2.9e-65 Sulfate transporter OS=Bos taurus GN=SLC26A2 PE=3 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.31754 BP_3 7.15 0.35 1266 189242341 XP_001807206.1 465 9.9e-44 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270016565|gb|EFA13011.1| hypothetical protein TcasGA2_TC001976 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31756 BP_3 34.99 0.83 2315 752899225 XP_011267995.1 654 2.2e-65 PREDICTED: coatomer subunit zeta-1 [Camponotus floridanus] 346709586 AK384066.1 60 4.62732e-20 Bombyx mori mRNA, clone: fcaL06G10 K03626 EGD2, NACA nascent polypeptide-associated complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03626 Q94518 536 4.4e-53 Nascent polypeptide-associated complex subunit alpha OS=Drosophila melanogaster GN=Nacalpha PE=1 SV=2 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG3343 Vesicle coat complex COPI, zeta subunit Cluster-8309.31757 BP_3 267.05 6.52 2266 270009732 EFA06180.1 698 1.7e-70 hypothetical protein TcasGA2_TC009027 [Tribolium castaneum] 346709586 AK384066.1 60 4.52787e-20 Bombyx mori mRNA, clone: fcaL06G10 K03626 EGD2, NACA nascent polypeptide-associated complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03626 Q94518 536 4.3e-53 Nascent polypeptide-associated complex subunit alpha OS=Drosophila melanogaster GN=Nacalpha PE=1 SV=2 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG3343 Vesicle coat complex COPI, zeta subunit Cluster-8309.31761 BP_3 2005.76 16.00 6335 642921944 XP_008192953.1 8292 0.0e+00 PREDICTED: dedicator of cytokinesis protein 7 [Tribolium castaneum] 769853772 XM_011640095.1 123 1.21568e-54 PREDICTED: Pogonomyrmex barbatus dedicator of cytokinesis protein 7 (LOC105428043), mRNA -- -- -- -- Q96N67 4645 0.0e+00 Dedicator of cytokinesis protein 7 OS=Homo sapiens GN=DOCK7 PE=1 SV=4 PF05412 Equine arterivirus Nsp2-type cysteine proteinase GO:0019082//GO:0016032 viral protein processing//viral process -- -- -- -- KOG1997 PH domain-containing protein Cluster-8309.31762 BP_3 272.97 3.81 3746 91089675 XP_974428.1 1381 1.8e-149 PREDICTED: probable trans-2-enoyl-CoA reductase, mitochondrial [Tribolium castaneum]>gi|270012629|gb|EFA09077.1| hypothetical protein TcasGA2_TC006794 [Tribolium castaneum] -- -- -- -- -- K07512 MECR, NRBF1 mitochondrial trans-2-enoyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07512 Q9V6U9 1031 2.8e-110 Probable trans-2-enoyl-CoA reductase, mitochondrial OS=Drosophila melanogaster GN=CG16935 PE=3 SV=2 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0000166//GO:0008270//GO:0016491 nucleotide binding//zinc ion binding//oxidoreductase activity -- -- KOG0025 Zn2+-binding dehydrogenase (nuclear receptor binding factor-1) Cluster-8309.31763 BP_3 4.51 0.35 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31765 BP_3 295.83 2.16 6885 549438529 AGX25153.1 1932 4.2e-213 sulfhydryl oxidase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- O61491 815 5.8e-85 Flotillin-1 OS=Drosophila melanogaster GN=Flo-1 PE=2 SV=1 PF01743//PF00085//PF04777 Poly A polymerase head domain//Thioredoxin//Erv1 / Alr family GO:0045454//GO:0055114//GO:0006396 cell redox homeostasis//oxidation-reduction process//RNA processing GO:0016779//GO:0016972//GO:0003723 nucleotidyltransferase activity//thiol oxidase activity//RNA binding -- -- KOG1731 FAD-dependent sulfhydryl oxidase/quiescin and related proteins Cluster-8309.31767 BP_3 1212.70 11.56 5348 549438529 AGX25153.1 1932 3.3e-213 sulfhydryl oxidase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61491 1566 3.7e-172 Flotillin-1 OS=Drosophila melanogaster GN=Flo-1 PE=2 SV=1 PF01743//PF04777//PF00085 Poly A polymerase head domain//Erv1 / Alr family//Thioredoxin GO:0006396//GO:0045454//GO:0055114 RNA processing//cell redox homeostasis//oxidation-reduction process GO:0016972//GO:0016779//GO:0003723 thiol oxidase activity//nucleotidyltransferase activity//RNA binding -- -- KOG1731 FAD-dependent sulfhydryl oxidase/quiescin and related proteins Cluster-8309.31769 BP_3 55.00 1.76 1799 91093509 XP_969295.1 1113 1.0e-118 PREDICTED: ras-related protein Rab-39B [Tribolium castaneum]>gi|270002676|gb|EEZ99123.1| hypothetical protein TcasGA2_TC005229 [Tribolium castaneum] -- -- -- -- -- K07925 RAB39B Ras-related protein Rab-39B http://www.genome.jp/dbget-bin/www_bget?ko:K07925 Q8BHD0 613 4.0e-62 Ras-related protein Rab-39A OS=Mus musculus GN=Rab39a PE=1 SV=1 PF08477//PF03193//PF01926//PF04670//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family GO:0015031//GO:0007264 protein transport//small GTPase mediated signal transduction GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.31771 BP_3 213.94 8.52 1502 478254830 ENN75066.1 466 9.0e-44 hypothetical protein YQE_08379, partial [Dendroctonus ponderosae] -- -- -- -- -- K16833 PPP1R2, IPP2 protein phosphatase inhibitor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16833 P11845 230 8.6e-18 Protein phosphatase inhibitor 2 OS=Oryctolagus cuniculus GN=PPP1R2 PE=1 SV=3 PF04979//PF04272 Protein phosphatase inhibitor 2 (IPP-2)//Phospholamban GO:0043666//GO:0006816//GO:0009966//GO:0006810 regulation of phosphoprotein phosphatase activity//calcium ion transport//regulation of signal transduction//transport GO:0005246//GO:0004864//GO:0042030 calcium channel regulator activity//protein phosphatase inhibitor activity//ATPase inhibitor activity GO:0016020 membrane KOG4041 Protein phosphatase 1, regulatory (inhibitor) subunit PPP1R2 Cluster-8309.31772 BP_3 148.71 5.77 1534 642918287 XP_008191445.1 486 4.4e-46 PREDICTED: uncharacterized protein LOC655985 isoform X1 [Tribolium castaneum]>gi|270003276|gb|EEZ99723.1| hypothetical protein TcasGA2_TC002488 [Tribolium castaneum] -- -- -- -- -- K07127 uraH, pucM, hiuH 5-hydroxyisourate hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07127 Q9CRB3 246 1.2e-19 5-hydroxyisourate hydrolase OS=Mus musculus GN=Urah PE=1 SV=1 PF01060 Transthyretin-like family GO:0006144//GO:0006810 purine nucleobase metabolic process//transport GO:0033971 hydroxyisourate hydrolase activity GO:0005615 extracellular space KOG3006 Transthyretin and related proteins Cluster-8309.31774 BP_3 819.33 29.71 1621 546683249 ERL93081.1 583 2.6e-57 hypothetical protein D910_10383 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q71RG4 208 3.3e-15 Transmembrane and ubiquitin-like domain-containing protein 2 OS=Homo sapiens GN=TMUB2 PE=1 SV=2 PF00240//PF00032 Ubiquitin family//Cytochrome b(C-terminal)/b6/petD GO:0006118 obsolete electron transport GO:0005515//GO:0016491//GO:0009055 protein binding//oxidoreductase activity//electron carrier activity GO:0016020 membrane -- -- Cluster-8309.31777 BP_3 137.84 4.89 1650 642922919 XP_008200452.1 634 3.3e-63 PREDICTED: uncharacterized protein LOC103314926 [Tribolium castaneum] -- -- -- -- -- K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9BX70 222 8.0e-17 BTB/POZ domain-containing protein 2 OS=Homo sapiens GN=BTBD2 PE=1 SV=1 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.31778 BP_3 20.04 0.79 1509 91093619 XP_972048.1 417 4.3e-38 PREDICTED: 60S ribosomal protein L26 [Tribolium castaneum]>gi|270015756|gb|EFA12204.1| hypothetical protein TcasGA2_TC005120 [Tribolium castaneum] 70909792 AM049083.1 162 5.94846e-77 Curculio glandium mRNA for ribosomal protein L26e (rpL26e gene) K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P61256 378 5.9e-35 60S ribosomal protein L26 OS=Macaca fascicularis GN=RPL26 PE=2 SV=1 PF16906 Ribosomal proteins L26 eukaryotic, L24P archaeal GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit KOG3401 60S ribosomal protein L26 Cluster-8309.31779 BP_3 16.90 0.32 2848 646705100 KDR12979.1 280 6.3e-22 hypothetical protein L798_13185 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- A7E3W5 156 6.2e-09 Synaptogyrin-2 OS=Bos taurus GN=SYNGR2 PE=2 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.31780 BP_3 409.00 60.60 617 -- -- -- -- -- 820857101 XM_003696473.2 71 9.08518e-27 PREDICTED: Apis florea 26S proteasome complex subunit DSS1 (LOC100863585), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31782 BP_3 516.71 43.90 859 642915202 XP_008190517.1 420 1.1e-38 PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum]>gi|642915204|ref|XP_008190519.1| PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31783 BP_3 15.71 0.33 2590 642915200 XP_008190516.1 1322 8.5e-143 PREDICTED: myb-like protein X isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULV3 169 1.8e-10 Cip1-interacting zinc finger protein OS=Homo sapiens GN=CIZ1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31784 BP_3 77.00 19.69 480 197927108 NP_001128195.1 164 3.0e-09 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 [Tribolium castaneum]>gi|642929132|ref|XP_008195704.1| PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3MFK1 124 5.4e-06 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 OS=Drosophila ananassae GN=GF13081 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31786 BP_3 809.41 11.80 3598 91085981 XP_971976.1 3595 0.0e+00 PREDICTED: cullin-1 [Tribolium castaneum]>gi|642927556|ref|XP_008195314.1| PREDICTED: cullin-1 [Tribolium castaneum] -- -- -- -- -- K03347 CUL1, CDC53 cullin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03347 Q9WTX6 3029 0.0e+00 Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1 PF00888//PF03965 Cullin family//Penicillinase repressor GO:0045892//GO:0006511 negative regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process GO:0031625//GO:0003677 ubiquitin protein ligase binding//DNA binding -- -- KOG2166 Cullins Cluster-8309.31788 BP_3 8.16 1.58 540 385199976 AFI45036.1 161 7.5e-09 cytochrome P450 CYP6DG1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.31790 BP_3 94.78 1.38 3603 189237709 XP_001810287.1 1203 7.5e-129 PREDICTED: protein brambleberry-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I6V1W0 541 1.8e-53 Protein brambleberry OS=Danio rerio GN=bmb PE=2 SV=1 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.31791 BP_3 231.22 3.06 3935 642924296 XP_008194236.1 1397 2.6e-151 PREDICTED: protein brambleberry-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I6V1W0 604 9.6e-61 Protein brambleberry OS=Danio rerio GN=bmb PE=2 SV=1 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.31792 BP_3 64.50 1.79 2032 270014557 EFA11005.1 293 1.4e-23 hypothetical protein TcasGA2_TC004590 [Tribolium castaneum] 642911747 XM_008202503.1 179 2.85784e-86 PREDICTED: Tribolium castaneum 14-3-3 protein zeta (LOC660150), mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 260 3.9e-21 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.31794 BP_3 6.00 1.20 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31795 BP_3 446.84 15.74 1660 642937984 XP_008199157.1 397 1.0e-35 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5PK40 281 1.2e-23 Choline transporter-like protein 3 OS=Bos taurus GN=SLC44A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.31796 BP_3 1666.67 24.53 3567 91089279 XP_970539.1 2343 4.8e-261 PREDICTED: serine/threonine-protein kinase unc-51 isoform X1 [Tribolium castaneum]>gi|270011454|gb|EFA07902.1| hypothetical protein TcasGA2_TC005477 [Tribolium castaneum] 820865549 XM_003698790.2 61 1.99186e-20 PREDICTED: Apis florea serine/threonine-protein kinase unc-51 (LOC100864929), transcript variant X1, mRNA K08269 ULK1_2_3, ATG1 serine/threonine-protein kinase ULK/ATG1 http://www.genome.jp/dbget-bin/www_bget?ko:K08269 Q8IYT8 967 7.1e-103 Serine/threonine-protein kinase ULK2 OS=Homo sapiens GN=ULK2 PE=1 SV=3 PF07714//PF12063//PF06293//PF00069 Protein tyrosine kinase//Domain of unknown function (DUF3543)//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0000166//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//nucleotide binding//ATP binding GO:0016020 membrane KOG0595 Serine/threonine-protein kinase involved in autophagy Cluster-8309.31798 BP_3 1380.87 14.43 4903 189236467 XP_974325.2 3327 0.0e+00 PREDICTED: protein transport protein Sec24A [Tribolium castaneum]>gi|642919906|ref|XP_008192119.1| PREDICTED: protein transport protein Sec24A [Tribolium castaneum]>gi|270005372|gb|EFA01820.1| hypothetical protein TcasGA2_TC007422 [Tribolium castaneum] -- -- -- -- -- K14007 SEC24 protein transport protein SEC24 http://www.genome.jp/dbget-bin/www_bget?ko:K14007 O95487 2150 6.5e-240 Protein transport protein Sec24B OS=Homo sapiens GN=SEC24B PE=1 SV=2 PF04811//PF04810//PF04815 Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1985 Vesicle coat complex COPII, subunit SEC24/subunit SFB2 Cluster-8309.31800 BP_3 1029.43 14.07 3818 189240740 XP_968238.2 2495 1.2e-278 PREDICTED: phospholipase A-2-activating protein [Tribolium castaneum] -- -- -- -- -- K14018 PLAA, DOA1, UFD3 phospholipase A-2-activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K14018 Q9Y263 1106 5.8e-119 Phospholipase A-2-activating protein OS=Homo sapiens GN=PLAA PE=1 SV=2 PF05676//PF00400 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//WD domain, G-beta repeat GO:0006120//GO:0006744//GO:0006814//GO:0006118//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//obsolete electron transport//proton transport GO:0003954//GO:0005515//GO:0008137 NADH dehydrogenase activity//protein binding//NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion KOG0301 Phospholipase A2-activating protein (contains WD40 repeats) Cluster-8309.31803 BP_3 6.31 0.31 1283 751231546 XP_011169340.1 514 2.1e-49 PREDICTED: cdc42 homolog isoform X1 [Solenopsis invicta] 755890983 XM_005189166.2 106 6.79752e-46 PREDICTED: Musca domestica cdc42 homolog (LOC101898849), transcript variant X2, mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 P40793 505 9.5e-50 Cdc42 homolog OS=Drosophila melanogaster GN=Cdc42 PE=1 SV=1 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.31804 BP_3 218.18 7.71 1656 340711564 XP_003394345.1 1024 2.0e-108 PREDICTED: zinc finger CCCH-type with G patch domain-containing protein [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q17CQ8 998 8.3e-107 Zinc finger CCCH-type with G patch domain-containing protein OS=Aedes aegypti GN=AAEL004458 PE=3 SV=1 PF01585//PF00642 G-patch domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0003676//GO:0046872 nucleic acid binding//metal ion binding -- -- KOG2185 Predicted RNA-processing protein, contains G-patch domain Cluster-8309.31805 BP_3 84.32 3.01 1644 270014745 EFA11193.1 194 3.4e-12 hypothetical protein TcasGA2_TC004801 [Tribolium castaneum] -- -- -- -- -- K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I1A6 171 6.5e-11 Endophilin-A OS=Drosophila willistoni GN=endoA PE=3 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation Cluster-8309.31806 BP_3 85.85 0.99 4470 189234578 XP_974655.2 1464 5.0e-159 PREDICTED: glucosidase 2 subunit beta [Tribolium castaneum] 760445822 XM_011401678.1 38 1.52682e-07 Auxenochlorella protothecoides Protein disulfide-isomerase 1 partial mRNA K08288 PRKCSH protein kinase C substrate 80K-H http://www.genome.jp/dbget-bin/www_bget?ko:K08288 O08795 931 1.3e-98 Glucosidase 2 subunit beta OS=Mus musculus GN=Prkcsh PE=1 SV=1 PF13499//PF04147//PF13833//PF13405//PF00057//PF04111//PF00085//PF03015//PF00036//PF13202 EF-hand domain pair//Nop14-like family//EF-hand domain pair//EF-hand domain//Low-density lipoprotein receptor domain class A//Autophagy protein Apg6//Thioredoxin//Male sterility protein//EF hand//EF hand GO:0045454//GO:0006914 cell redox homeostasis//autophagy GO:0005515//GO:0080019//GO:0005509 protein binding//fatty-acyl-CoA reductase (alcohol-forming) activity//calcium ion binding GO:0032040 small-subunit processome KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.31808 BP_3 392.46 5.34 3833 642911025 XP_008193513.1 3368 0.0e+00 PREDICTED: contactin [Tribolium castaneum] 817219709 XM_012430138.1 110 1.23553e-47 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 2249 1.7e-251 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF13895//PF01618//PF00041//PF16656 Immunoglobulin domain//MotA/TolQ/ExbB proton channel family//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006810//GO:0019497//GO:0015031//GO:0006771 transport//hexachlorocyclohexane metabolic process//protein transport//riboflavin metabolic process GO:0005515//GO:0046872//GO:0008565//GO:0003993 protein binding//metal ion binding//protein transporter activity//acid phosphatase activity GO:0016020 membrane -- -- Cluster-8309.31811 BP_3 2031.91 36.10 3005 91081871 XP_968443.1 3058 0.0e+00 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q9UL12 1899 5.0e-211 Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1 PF12831//PF01134//PF01266//PF07992//PF11501//PF13241//PF01494 FAD dependent oxidoreductase//Glucose inhibited division protein A//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Non structural protein Nsp1//Putative NAD(P)-binding//FAD binding domain GO:0044710//GO:0019354//GO:0006508//GO:0008033//GO:0006779//GO:0055114 single-organism metabolic process//siroheme biosynthetic process//proteolysis//tRNA processing//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0016491//GO:0043115//GO:0008242//GO:0003824//GO:0016788//GO:0016817//GO:0004197//GO:0050660//GO:0016740//GO:0071949 oxidoreductase activity//precorrin-2 dehydrogenase activity//omega peptidase activity//catalytic activity//hydrolase activity, acting on ester bonds//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//flavin adenine dinucleotide binding//transferase activity//FAD binding -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.31814 BP_3 955.81 12.15 4084 546676948 ERL87872.1 1823 1.1e-200 hypothetical protein D910_05260 [Dendroctonus ponderosae] -- -- -- -- -- K10416 DYNC1LI, DNCLI dynein light intermediate chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10416 O43237 989 2.3e-105 Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens GN=DYNC1LI2 PE=1 SV=1 PF00005//PF08477//PF02892//PF00503//PF00025//PF10662//PF13465 ABC transporter//Ras of Complex, Roc, domain of DAPkinase//BED zinc finger//G-protein alpha subunit//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation//Zinc-finger double domain GO:0007165//GO:0006576//GO:0007186//GO:0007264 signal transduction//cellular biogenic amine metabolic process//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0003677//GO:0031683//GO:0005524//GO:0003924//GO:0016887//GO:0019001//GO:0004871//GO:0005525//GO:0046872 DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//ATPase activity//guanyl nucleotide binding//signal transducer activity//GTP binding//metal ion binding -- -- KOG2482 Predicted C2H2-type Zn-finger protein Cluster-8309.31815 BP_3 713.62 17.47 2261 642940150 XP_008194838.1 698 1.7e-70 PREDICTED: protein SPT2 homolog [Tribolium castaneum]>gi|270016871|gb|EFA13317.1| hypothetical protein TcasGA2_TC006901 [Tribolium castaneum] -- -- -- -- -- K15193 SPTY2D1, SPT2 protein SPT2 http://www.genome.jp/dbget-bin/www_bget?ko:K15193 Q8IMP6 253 2.8e-20 Protein SPT2 homolog OS=Drosophila melanogaster GN=CG5815 PE=1 SV=1 PF13971 Meiosis-specific protein Mei4 GO:0006310//GO:0042138 DNA recombination//meiotic DNA double-strand break formation -- -- -- -- -- -- Cluster-8309.31818 BP_3 25.00 6.10 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31819 BP_3 4593.48 350.73 923 189235487 XP_968396.2 1031 1.7e-109 PREDICTED: failed axon connections isoform X1 [Tribolium castaneum] 645031495 XM_008211925.1 220 2.05553e-109 PREDICTED: Nasonia vitripennis failed axon connections (LOC100123191), transcript variant X3, mRNA -- -- -- -- Q95RI5 877 5.0e-93 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF13417 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG4244 Failed axon connections (fax) protein/glutathione S-transferase-like protein Cluster-8309.31820 BP_3 3308.25 46.99 3685 642920513 XP_008192381.1 2781 0.0e+00 PREDICTED: eukaryotic translation initiation factor 5B [Tribolium castaneum] 665796798 XM_008547981.1 498 0 PREDICTED: Microplitis demolitor eukaryotic translation initiation factor 5B (LOC103570285), mRNA K03243 EIF5B translation initiation factor 5B http://www.genome.jp/dbget-bin/www_bget?ko:K03243 O60841 2249 1.6e-251 Eukaryotic translation initiation factor 5B OS=Homo sapiens GN=EIF5B PE=1 SV=4 PF01926//PF03144//PF08477//PF03376 50S ribosome-binding GTPase//Elongation factor Tu domain 2//Ras of Complex, Roc, domain of DAPkinase//Adenovirus E3B protein GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0016020 membrane KOG1144 Translation initiation factor 5B (eIF-5B) Cluster-8309.31826 BP_3 479.20 7.61 3326 668458814 KFB46677.1 1068 3.1e-113 hypothetical protein ZHAS_00014689 [Anopheles sinensis] -- -- -- -- -- K13577 SLC25A10, DIC solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13577 Q9UBX3 826 1.5e-86 Mitochondrial dicarboxylate carrier OS=Homo sapiens GN=SLC25A10 PE=1 SV=2 PF10483//PF09807 Elongator subunit Iki1//Elongation complex protein 6 -- -- -- -- GO:0033588 Elongator holoenzyme complex KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.31830 BP_3 1460.17 75.09 1229 291170322 ADD82417.1 552 7.8e-54 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 321 1.97378e-165 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.31832 BP_3 280.85 4.06 3628 91089961 XP_973612.1 1197 3.7e-128 PREDICTED: beta-1,4-galactosyltransferase 7 [Tribolium castaneum]>gi|270013550|gb|EFA09998.1| hypothetical protein TcasGA2_TC012167 [Tribolium castaneum] -- -- -- -- -- K00733 B4GALT7 xylosylprotein 4-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00733 Q8R087 728 3.7e-75 Beta-1,4-galactosyltransferase 7 OS=Mus musculus GN=B4galt7 PE=2 SV=1 -- -- GO:0005975 carbohydrate metabolic process GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.31833 BP_3 298.06 3.00 5073 546675851 ERL86956.1 2661 9.1e-298 hypothetical protein D910_04359 [Dendroctonus ponderosae] 676491074 XM_009067230.1 96 9.93438e-40 Lottia gigantea hypothetical protein mRNA K12179 COPS6, CSN6 COP9 signalosome complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12179 Q9VCY3 1146 1.8e-123 COP9 signalosome complex subunit 6 OS=Drosophila melanogaster GN=CSN6 PE=1 SV=1 PF05028//PF01398//PF00848 Poly (ADP-ribose) glycohydrolase (PARG)//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Ring hydroxylating alpha subunit (catalytic domain) GO:0019439//GO:0005975//GO:0055114 aromatic compound catabolic process//carbohydrate metabolic process//oxidation-reduction process GO:0051537//GO:0005515//GO:0016708//GO:0005506//GO:0004649 2 iron, 2 sulfur cluster binding//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor//iron ion binding//poly(ADP-ribose) glycohydrolase activity -- -- KOG3050 COP9 signalosome, subunit CSN6 Cluster-8309.31836 BP_3 2663.26 78.02 1937 91089983 XP_974005.1 2115 7.1e-235 PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934014|ref|XP_008197604.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934016|ref|XP_008197605.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|270013684|gb|EFA10132.1| hypothetical protein TcasGA2_TC012312 [Tribolium castaneum] -- -- -- -- -- K15779 PGM2 phosphoglucomutase / phosphopentomutase http://www.genome.jp/dbget-bin/www_bget?ko:K15779 Q96G03 1526 5.8e-168 Phosphoglucomutase-2 OS=Homo sapiens GN=PGM2 PE=1 SV=4 PF02878//PF00408//PF02879//PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III GO:0071704//GO:0005975 organic substance metabolic process//carbohydrate metabolic process GO:0016868//GO:0000287 intramolecular transferase activity, phosphotransferases//magnesium ion binding -- -- KOG1220 Phosphoglucomutase/phosphomannomutase Cluster-8309.31837 BP_3 1271.68 15.87 4154 642913764 XP_008201151.1 5037 0.0e+00 PREDICTED: neuropathy target esterase sws isoform X3 [Tribolium castaneum] -- -- -- -- -- K14676 NTE, NRE lysophospholipid hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14676 B4IL64 3174 0.0e+00 Neuropathy target esterase sws OS=Drosophila sechellia GN=sws PE=3 SV=1 PF12387//PF01734 Pestivirus NS2 peptidase//Patatin-like phospholipase GO:0006508//GO:0006629//GO:0006144 proteolysis//lipid metabolic process//purine nucleobase metabolic process GO:0017111//GO:0004252//GO:0016817//GO:0004197//GO:0070008//GO:0003968 nucleoside-triphosphatase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//serine-type exopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG2968 Predicted esterase of the alpha-beta hydrolase superfamily (Neuropathy target esterase), contains cAMP-binding domains Cluster-8309.31843 BP_3 1578.45 10.97 7224 642935013 XP_008199906.1 2193 2.4e-243 PREDICTED: helicase ARIP4 isoform X1 [Tribolium castaneum] 751217932 XM_011163680.1 98 1.09543e-40 PREDICTED: Solenopsis invicta uncharacterized LOC105197370 (LOC105197370), transcript variant X2, mRNA K10876 RAD54L2 RAD54-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10876 A4IHD2 1326 3.4e-144 Helicase ARIP4 OS=Xenopus tropicalis GN=rad54l2 PE=2 SV=1 PF01284//PF04851//PF00176 Membrane-associating domain//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding GO:0016020 membrane KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.31844 BP_3 78.41 0.59 6682 189241560 XP_001809966.1 1592 1.1e-173 PREDICTED: rab GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ17 914 1.9e-96 Rab GTPase-activating protein 1-like OS=Gallus gallus GN=RABGAP1L PE=2 SV=1 PF07776//PF14719//PF00096//PF07660//PF16622//PF02892//PF13912//PF05443//PF00640//PF13465 Zinc-finger associated domain (zf-AD)//Phosphotyrosine interaction domain (PTB/PID)//Zinc finger, C2H2 type//Secretin and TonB N terminus short domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//ROS/MUCR transcriptional regulator protein//Phosphotyrosine interaction domain (PTB/PID)//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0005515//GO:0003677//GO:0008270 metal ion binding//protein binding//DNA binding//zinc ion binding GO:0019867//GO:0005634 outer membrane//nucleus -- -- Cluster-8309.31845 BP_3 56.62 2.03 1635 270004594 EFA01042.1 1514 2.9e-165 hypothetical protein TcasGA2_TC003958 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q80W31 563 2.3e-56 Zinc finger protein 569 OS=Mus musculus GN=Znf569 PE=2 SV=2 PF13465//PF00096//PF01155//PF13912//PF01363 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//C2H2-type zinc finger//FYVE zinc finger GO:0006464 cellular protein modification process GO:0016151//GO:0046872 nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.31846 BP_3 408.00 20.42 1255 332373030 AEE61656.1 476 5.2e-45 unknown [Dendroctonus ponderosae]>gi|478251479|gb|ENN71942.1| hypothetical protein YQE_11376, partial [Dendroctonus ponderosae]>gi|546681844|gb|ERL91859.1| hypothetical protein D910_09183 [Dendroctonus ponderosae] -- -- -- -- -- K10419 DYNLRB, DNCL2 dynein light chain roadblock-type http://www.genome.jp/dbget-bin/www_bget?ko:K10419 Q32P85 391 1.5e-36 Dynein light chain roadblock-type 2 OS=Bos taurus GN=DYNLRB2 PE=3 SV=1 PF16672 Ragulator complex protein LAMTOR5 GO:0019079//GO:0043066//GO:0043154 viral genome replication//negative regulation of apoptotic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process -- -- GO:0071986//GO:0005737 Ragulator complex//cytoplasm KOG4115 Dynein-associated protein Roadblock Cluster-8309.31847 BP_3 137.59 8.85 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31849 BP_3 2048.56 41.00 2700 478251931 ENN72369.1 3261 0.0e+00 hypothetical protein YQE_11004, partial [Dendroctonus ponderosae] 195498296 XM_002096426.1 190 2.92544e-92 Drosophila yakuba GE25042 (Dyak\GE25042), partial mRNA -- -- -- -- Q8C419 156 5.9e-09 Probable G-protein coupled receptor 158 OS=Mus musculus GN=Gpr158 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.31850 BP_3 108.16 0.75 7269 91075968 XP_969381.1 1380 4.5e-149 PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|642910393|ref|XP_008190714.1| PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|270014619|gb|EFA11067.1| hypothetical protein TcasGA2_TC004663 [Tribolium castaneum] -- -- -- -- -- K03522 fixB, etfA electron transfer flavoprotein alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03522 P13803 751 1.6e-77 Electron transfer flavoprotein subunit alpha, mitochondrial OS=Rattus norvegicus GN=Etfa PE=1 SV=4 PF04083//PF12740//PF16987//PF03403//PF00326//PF07819//PF07224//PF02230//PF06821//PF15453 Partial alpha/beta-hydrolase lipase region//Chlorophyllase enzyme//KIX domain//Platelet-activating factor acetylhydrolase, isoform II//Prolyl oligopeptidase family//PGAP1-like protein//Chlorophyllase//Phospholipase/Carboxylesterase//Serine hydrolase//Protein incorporated later into Tight Junctions GO:0006508//GO:0016042//GO:0006629//GO:0015994//GO:0006355//GO:0046486//GO:0015996//GO:0006505//GO:0006886 proteolysis//lipid catabolic process//lipid metabolic process//chlorophyll metabolic process//regulation of transcription, DNA-templated//glycerolipid metabolic process//chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport GO:0016788//GO:0047746//GO:0003712//GO:0008236//GO:0003847//GO:0016787 hydrolase activity, acting on ester bonds//chlorophyllase activity//transcription cofactor activity//serine-type peptidase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247//GO:0005667//GO:0005923 1-alkyl-2-acetylglycerophosphocholine esterase complex//transcription factor complex//bicellular tight junction KOG3954 Electron transfer flavoprotein, alpha subunit Cluster-8309.31851 BP_3 3376.00 445.45 657 91081217 XP_975622.1 483 4.2e-46 PREDICTED: ecdysteroid-regulated 16 kDa protein [Tribolium castaneum]>gi|270006449|gb|EFA02897.1| hypothetical protein TcasGA2_TC008202 [Tribolium castaneum] -- -- -- -- -- K13443 NPC2 Niemann-Pick C2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K13443 Q9VQ62 378 2.6e-35 Protein NPC2 homolog OS=Drosophila melanogaster GN=Npc2a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31855 BP_3 966.67 14.89 3420 546682487 ERL92410.1 2376 6.8e-265 hypothetical protein D910_09724 [Dendroctonus ponderosae] 198451987 XM_001358537.2 567 0 Drosophila pseudoobscura pseudoobscura GA21805 (Dpse\GA21805), partial mRNA K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q86XK2 2044 8.8e-228 F-box only protein 11 OS=Homo sapiens GN=FBXO11 PE=1 SV=3 PF03284//PF02207 Phenazine biosynthesis protein A/B//Putative zinc finger in N-recognin (UBR box) GO:0017000 antibiotic biosynthetic process GO:0008270 zinc ion binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.31856 BP_3 537.36 6.11 4534 270010664 EFA07112.1 2150 1.5e-238 hypothetical protein TcasGA2_TC010102 [Tribolium castaneum] -- -- -- -- -- K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q7TPD1 1170 2.6e-126 F-box only protein 11 OS=Mus musculus GN=Fbxo11 PE=1 SV=3 PF12937//PF00646//PF15966 F-box-like//F-box domain//F-box -- -- GO:0005515 protein binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.31857 BP_3 320.56 4.07 4086 546682487 ERL92410.1 2376 8.2e-265 hypothetical protein D910_09724 [Dendroctonus ponderosae] 198451987 XM_001358537.2 567 0 Drosophila pseudoobscura pseudoobscura GA21805 (Dpse\GA21805), partial mRNA K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q86XK2 2044 1.1e-227 F-box only protein 11 OS=Homo sapiens GN=FBXO11 PE=1 SV=3 PF03284//PF02207//PF07839 Phenazine biosynthesis protein A/B//Putative zinc finger in N-recognin (UBR box)//Plant calmodulin-binding domain GO:0017000 antibiotic biosynthetic process GO:0008270//GO:0005516 zinc ion binding//calmodulin binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.31858 BP_3 31.30 2.87 817 270005507 EFA01955.1 248 9.3e-19 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P30104 170 4.2e-11 Glutathione S-transferase 1-1 OS=Drosophila erecta GN=GstD1 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31860 BP_3 272.00 29.38 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31861 BP_3 159.26 8.30 1217 91084021 XP_975350.1 307 2.0e-25 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 820852256 XM_003694739.2 73 1.42348e-27 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX23 (LOC100863532), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q5RC67 212 8.5e-16 Probable ATP-dependent RNA helicase DDX23 OS=Pongo abelii GN=DDX23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.31864 BP_3 930.20 14.76 3330 91089287 XP_971047.1 1012 9.7e-107 PREDICTED: derlin-2 [Tribolium castaneum]>gi|270012498|gb|EFA08946.1| hypothetical protein TcasGA2_TC006653 [Tribolium castaneum] 762105781 XR_901040.1 45 1.45692e-11 PREDICTED: Crassostrea gigas derlin-2-like (LOC105333927), transcript variant X2, misc_RNA K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q8BNI4 871 8.9e-92 Derlin-2 OS=Mus musculus GN=Derl2 PE=1 SV=2 PF01694//PF01277 Rhomboid family//Oleosin -- -- GO:0004252 serine-type endopeptidase activity GO:0016021//GO:0012511 integral component of membrane//monolayer-surrounded lipid storage body KOG0858 Predicted membrane protein Cluster-8309.31866 BP_3 767.14 7.78 5044 546674614 ERL85963.1 835 4.9e-86 hypothetical protein D910_03378 [Dendroctonus ponderosae] 597798758 XM_007260859.1 49 1.3237e-13 PREDICTED: Astyanax mexicanus superoxide dismutase 2, mitochondrial (sod2), mRNA K04564 SOD2 superoxide dismutase, Fe-Mn family http://www.genome.jp/dbget-bin/www_bget?ko:K04564 P31161 726 8.8e-75 Superoxide dismutase [Mn] 1, mitochondrial OS=Caenorhabditis elegans GN=sod-2 PE=1 SV=1 PF02777//PF02285//PF04506//PF16672//PF00081 Iron/manganese superoxide dismutases, C-terminal domain//Cytochrome oxidase c subunit VIII//Rft protein//Ragulator complex protein LAMTOR5//Iron/manganese superoxide dismutases, alpha-hairpin domain GO:0019079//GO:0006123//GO:0055114//GO:0015992//GO:0006869//GO:0043066//GO:0043154//GO:0006801 viral genome replication//mitochondrial electron transport, cytochrome c to oxygen//oxidation-reduction process//proton transport//lipid transport//negative regulation of apoptotic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//superoxide metabolic process GO:0004784//GO:0005319//GO:0046872//GO:0004129 superoxide dismutase activity//lipid transporter activity//metal ion binding//cytochrome-c oxidase activity GO:0016021//GO:0005737//GO:0045277//GO:0071986 integral component of membrane//cytoplasm//respiratory chain complex IV//Ragulator complex KOG0876 Manganese superoxide dismutase Cluster-8309.31867 BP_3 1187.41 14.66 4196 546674614 ERL85963.1 835 4.1e-86 hypothetical protein D910_03378 [Dendroctonus ponderosae] 597798758 XM_007260859.1 49 1.09956e-13 PREDICTED: Astyanax mexicanus superoxide dismutase 2, mitochondrial (sod2), mRNA K04564 SOD2 superoxide dismutase, Fe-Mn family http://www.genome.jp/dbget-bin/www_bget?ko:K04564 P31161 726 7.3e-75 Superoxide dismutase [Mn] 1, mitochondrial OS=Caenorhabditis elegans GN=sod-2 PE=1 SV=1 PF16672//PF00081//PF04923//PF02777//PF04506 Ragulator complex protein LAMTOR5//Iron/manganese superoxide dismutases, alpha-hairpin domain//Ninjurin//Iron/manganese superoxide dismutases, C-terminal domain//Rft protein GO:0006801//GO:0007155//GO:0055114//GO:0043154//GO:0019079//GO:0006869//GO:0043066//GO:0042246 superoxide metabolic process//cell adhesion//oxidation-reduction process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//viral genome replication//lipid transport//negative regulation of apoptotic process//tissue regeneration GO:0046872//GO:0005319//GO:0004784 metal ion binding//lipid transporter activity//superoxide dismutase activity GO:0005737//GO:0016021//GO:0071986 cytoplasm//integral component of membrane//Ragulator complex KOG0876 Manganese superoxide dismutase Cluster-8309.31869 BP_3 967.49 91.93 799 332372879 AEE61581.1 508 6.4e-49 unknown [Dendroctonus ponderosae]>gi|478254197|gb|ENN74466.1| hypothetical protein YQE_08957, partial [Dendroctonus ponderosae] 665790676 XM_008562812.1 141 1.45727e-65 PREDICTED: Microplitis demolitor histone H2A.V (LOC103580890), mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P08991 492 1.9e-48 Histone H2A.V (Fragment) OS=Strongylocentrotus purpuratus GN=H2A.F/Z PE=1 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1757 Histone 2A Cluster-8309.3187 BP_3 34.88 0.87 2219 642931828 XP_971231.2 1133 6.0e-121 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q0VD31 378 8.7e-35 F-box/LRR-repeat protein 4 OS=Bos taurus GN=FBXL4 PE=2 SV=1 PF15966//PF00646//PF00560//PF12937//PF13516 F-box//F-box domain//Leucine Rich Repeat//F-box-like//Leucine Rich repeat -- -- GO:0005515 protein binding -- -- KOG4341 F-box protein containing LRR Cluster-8309.31871 BP_3 322.00 7.37 2398 642929315 XP_008195783.1 1357 6.9e-147 PREDICTED: uncharacterized protein LOC103312132 [Tribolium castaneum]>gi|270009640|gb|EFA06088.1| hypothetical protein TcasGA2_TC008925 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31872 BP_3 2020.98 21.81 4758 642932256 XP_008197035.1 1291 6.2e-139 PREDICTED: uncharacterized protein CG7065 homolog isoform X2 [Tribolium castaneum] 805785462 XM_012284975.1 63 2.05918e-21 PREDICTED: Megachile rotundata uncharacterized protein CG7065-like (LOC100874663), transcript variant X3, mRNA -- -- -- -- Q7YZA2 382 6.4e-35 Uncharacterized protein CG7065 OS=Drosophila melanogaster GN=CG7065 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31874 BP_3 36.62 1.99 1180 704178438 XP_010134461.1 314 3.0e-26 PREDICTED: ras-related protein Rab-2A isoform X2 [Buceros rhinoceros silvestris] -- -- -- -- -- K07877 RAB2A Ras-related protein Rab-2A http://www.genome.jp/dbget-bin/www_bget?ko:K07877 P53994 301 3.9e-26 Ras-related protein Rab-2A OS=Mus musculus GN=Rab2a PE=1 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.31875 BP_3 1402.38 13.29 5377 642940400 XP_008200547.1 1877 7.8e-207 PREDICTED: chitin deacetylase 5 isoform X8 [Tribolium castaneum] 827560342 XM_012695639.1 297 1.93779e-151 PREDICTED: Bombyx mori uncharacterized LOC101740429 (LOC101740429), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0006807//GO:0005975//GO:0006030 nitrogen compound metabolic process//carbohydrate metabolic process//chitin metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.31876 BP_3 712.14 4.81 7426 642932804 XP_008196990.1 7051 0.0e+00 PREDICTED: myosin heavy chain, non-muscle isoform X1 [Tribolium castaneum] 462326123 APGK01041549.1 824 0 Dendroctonus ponderosae Seq01041559, whole genome shotgun sequence K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 5930 0.0e+00 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF08471//PF01576//PF00612//PF00063 Class II vitamin B12-dependent ribonucleotide reductase//Myosin tail//IQ calmodulin-binding motif//Myosin head (motor domain) GO:0006206//GO:0055114//GO:0009186//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process GO:0003774//GO:0050897//GO:0005524//GO:0004748//GO:0005515 motor activity//cobalt ion binding//ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//protein binding GO:0016459//GO:0005971 myosin complex//ribonucleoside-diphosphate reductase complex KOG0161 Myosin class II heavy chain Cluster-8309.31877 BP_3 35.00 0.42 4314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31878 BP_3 1156.00 92.21 896 91077462 XP_968036.1 713 1.2e-72 PREDICTED: prefoldin subunit 3 [Tribolium castaneum]>gi|270002137|gb|EEZ98584.1| hypothetical protein TcasGA2_TC001098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGP6 476 1.5e-46 Prefoldin subunit 3 OS=Drosophila melanogaster GN=mgr PE=1 SV=3 PF01920//PF12761 Prefoldin subunit//Actin cytoskeleton-regulatory complex protein END3 GO:0006897//GO:0007015//GO:0006457 endocytosis//actin filament organization//protein folding GO:0051082 unfolded protein binding GO:0016272 prefoldin complex KOG3313 Molecular chaperone Prefoldin, subunit 3 Cluster-8309.31879 BP_3 640.66 6.31 5184 642934658 XP_008197755.1 4283 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.05189e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 531 3.7e-52 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF08727//PF01702//PF00595 Poliovirus 3A protein like//Queuine tRNA-ribosyltransferase//PDZ domain (Also known as DHR or GLGF) GO:0006144//GO:0008616//GO:0006400//GO:0006508 purine nucleobase metabolic process//queuosine biosynthetic process//tRNA modification//proteolysis GO:0005515//GO:0008479//GO:0004197//GO:0017111//GO:0003968 protein binding//queuine tRNA-ribosyltransferase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.31880 BP_3 653.00 17.79 2061 91087075 XP_974896.1 1525 2.0e-166 PREDICTED: nucleoporin GLE1 [Tribolium castaneum]>gi|642929462|ref|XP_008195850.1| PREDICTED: nucleoporin GLE1 [Tribolium castaneum]>gi|270009615|gb|EFA06063.1| hypothetical protein TcasGA2_TC008898 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4W1 583 1.4e-58 Nucleoporin GLE1 OS=Drosophila melanogaster GN=GLE1 PE=2 SV=1 PF07817 GLE1-like protein GO:0016973 poly(A)+ mRNA export from nucleus -- -- GO:0005643 nuclear pore KOG2412 Nuclear-export-signal (NES)-containing protein/polyadenylated-RNA export factor Cluster-8309.31882 BP_3 112.03 9.96 834 91076494 XP_972946.1 541 1.0e-52 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 394 4.6e-37 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31884 BP_3 31.00 0.95 1862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03051 Peptidase C1-like family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.31886 BP_3 1696.70 32.13 2837 91092168 XP_968081.1 571 1.1e-55 PREDICTED: uncharacterized protein LOC656458 [Tribolium castaneum]>gi|270014443|gb|EFA10891.1| hypothetical protein TcasGA2_TC001715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31887 BP_3 464.01 15.18 1765 91090488 XP_968919.1 1931 1.4e-213 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X2 [Tribolium castaneum]>gi|270013864|gb|EFA10312.1| hypothetical protein TcasGA2_TC012528 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q02157 633 1.9e-64 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 -- -- GO:0016042//GO:0046486//GO:0006629 lipid catabolic process//glycerolipid metabolic process//lipid metabolic process GO:0004806 triglyceride lipase activity GO:0005576 extracellular region -- -- Cluster-8309.31889 BP_3 44.67 0.47 4900 642934565 XP_008197717.1 3673 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 7.0e-93 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF00069//PF06293//PF04265//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Thiamin pyrophosphokinase, vitamin B1 binding domain//Protein tyrosine kinase GO:0009229//GO:0006468 thiamine diphosphate biosynthetic process//protein phosphorylation GO:0000166//GO:0016773//GO:0004672//GO:0030975//GO:0005524 nucleotide binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//thiamine binding//ATP binding GO:0016020 membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.31890 BP_3 872.10 6.92 6370 91078794 XP_970038.1 3616 0.0e+00 PREDICTED: WD repeat-containing protein 3 [Tribolium castaneum]>gi|270003730|gb|EFA00178.1| hypothetical protein TcasGA2_TC003001 [Tribolium castaneum] 642916053 XR_511345.1 322 2.90894e-165 PREDICTED: Tribolium castaneum uncharacterized LOC100141824 (LOC100141824), transcript variant X2, misc_RNA K14556 DIP2, UTP12, WDR3 U3 small nucleolar RNA-associated protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14556 Q9UNX4 2070 1.6e-230 WD repeat-containing protein 3 OS=Homo sapiens GN=WDR3 PE=1 SV=1 PF00400//PF00008//PF04494 WD domain, G-beta repeat//EGF-like domain//WD40 associated region in TFIID subunit, NTD2 domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.31891 BP_3 60.00 1.05 3034 254939725 ACT88125.1 765 3.9e-78 AT15141p [Drosophila melanogaster] 427776119 JX855312.1 1811 0 Portunus trituberculatus calmodulin (CaM) mRNA, complete cds K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P62153 758 1.0e-78 Calmodulin-A OS=Halocynthia roretzi PE=1 SV=2 PF02627//PF13499//PF13833//PF10591//PF13405//PF12763//PF02563//PF00036//PF03874//PF13202 Carboxymuconolactone decarboxylase family//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Cytoskeletal-regulatory complex EF hand//Polysaccharide biosynthesis/export protein//EF hand//RNA polymerase Rpb4//EF hand GO:0007165//GO:0006351//GO:0015774//GO:0006144//GO:0006206//GO:0055114 signal transduction//transcription, DNA-templated//polysaccharide transport//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0051920//GO:0003899//GO:0005515//GO:0015159//GO:0005509 peroxiredoxin activity//DNA-directed RNA polymerase activity//protein binding//polysaccharide transmembrane transporter activity//calcium ion binding GO:0016020//GO:0005578//GO:0005730 membrane//proteinaceous extracellular matrix//nucleolus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.31892 BP_3 4797.16 102.12 2556 332372973 AEE61628.1 1568 2.5e-171 unknown [Dendroctonus ponderosae]>gi|478253498|gb|ENN73825.1| hypothetical protein YQE_09603, partial [Dendroctonus ponderosae]>gi|546679120|gb|ERL89625.1| hypothetical protein D910_06990 [Dendroctonus ponderosae] 815776040 XM_012358994.1 116 3.79087e-51 PREDICTED: Linepithema humile innexin inx1 (LOC105680188), mRNA -- -- -- -- Q9XYN0 1453 2.2e-159 Innexin inx1 OS=Schistocerca americana GN=inx1 PE=1 SV=1 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.31895 BP_3 21.28 1.68 902 195131405 XP_002010141.1 220 1.8e-15 GI15765 [Drosophila mojavensis]>gi|193908591|gb|EDW07458.1| GI15765 [Drosophila mojavensis] -- -- -- -- -- K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 -- -- -- -- PF03051 Peptidase C1-like family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.31896 BP_3 28.63 0.34 4324 189238112 XP_001814047.1 373 1.6e-32 PREDICTED: bleomycin hydrolase [Tribolium castaneum]>gi|270008738|gb|EFA05186.1| hypothetical protein TcasGA2_TC015316 [Tribolium castaneum] 767931498 XM_005262871.3 83 1.42523e-32 PREDICTED: Homo sapiens KIAA0922 (KIAA0922), transcript variant X5, mRNA K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 P87362 321 6.9e-28 Bleomycin hydrolase OS=Gallus gallus GN=BLMH PE=1 SV=1 PF08485//PF03051//PF00112 Polysaccharide biosynthesis protein C-terminal//Peptidase C1-like family//Papain family cysteine protease GO:0006508//GO:0009225//GO:0009117//GO:0006012//GO:0009103 proteolysis//nucleotide-sugar metabolic process//nucleotide metabolic process//galactose metabolic process//lipopolysaccharide biosynthetic process GO:0004197//GO:0008234//GO:0003978 cysteine-type endopeptidase activity//cysteine-type peptidase activity//UDP-glucose 4-epimerase activity -- -- KOG4128 Bleomycin hydrolases and aminopeptidases of cysteine protease family Cluster-8309.31898 BP_3 87.61 3.42 1528 189240395 XP_967842.2 1865 5.5e-206 PREDICTED: lissencephaly-1 homolog [Tribolium castaneum] 195056833 XM_001995131.1 83 4.96392e-33 Drosophila grimshawi GH22777 (Dgri\GH22777), mRNA K16794 PAFAH1B1, LIS1 platelet-activating factor acetylhydrolase IB subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16794 Q7KNS3 1709 2.8e-189 Lissencephaly-1 homolog OS=Drosophila melanogaster GN=Lis-1 PE=1 SV=2 PF04508//PF08513//PF00400 Viral A-type inclusion protein repeat//LisH//WD domain, G-beta repeat GO:0016032 viral process GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.31899 BP_3 17.05 0.42 2255 332372580 AEE61432.1 1838 1.1e-202 unknown [Dendroctonus ponderosae]>gi|478260722|gb|ENN80403.1| hypothetical protein YQE_03175, partial [Dendroctonus ponderosae] -- -- -- -- -- K00825 AADAT, KAT2 kynurenine/2-aminoadipate aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00825 Q5E9N4 891 2.9e-94 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial OS=Bos taurus GN=AADAT PE=2 SV=1 PF00155//PF01212//PF01053 Aminotransferase class I and II//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0634 Aromatic amino acid aminotransferase and related proteins Cluster-8309.31901 BP_3 38.92 0.46 4395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02901 Pyruvate formate lyase-like -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.31905 BP_3 3.00 2.67 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31906 BP_3 1185.86 11.66 5192 642918013 XP_008198979.1 1028 2.1e-108 PREDICTED: cytochrome c1, heme protein, mitochondrial [Tribolium castaneum]>gi|270004913|gb|EFA01361.1| mitochondrial cytochrome c1 [Tribolium castaneum] -- -- -- -- -- K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 744 7.4e-77 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF00034//PF02167//PF13442 Cytochrome c//Cytochrome C1 family//Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0005488//GO:0009055//GO:0020037 binding//electron carrier activity//heme binding -- -- KOG3052 Cytochrome c1 Cluster-8309.31907 BP_3 238.46 6.48 2065 642923805 XP_008193890.1 1839 7.6e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 4.0e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.31908 BP_3 28.25 0.76 2093 642913503 XP_008201041.1 960 6.5e-101 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 Q91YJ2 499 7.7e-49 Sorting nexin-4 OS=Mus musculus GN=Snx4 PE=2 SV=1 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.31909 BP_3 328.42 2.23 7388 642918367 XP_008200036.1 2521 2.3e-281 PREDICTED: titin-like isoform X1 [Tribolium castaneum] 462348959 APGK01033436.1 65 2.47733e-22 Dendroctonus ponderosae Seq01033446, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31910 BP_3 293.37 8.08 2041 642913503 XP_008201041.1 1630 1.3e-178 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 A1A4L0 873 3.2e-92 Sorting nexin-4 OS=Bos taurus GN=SNX4 PE=2 SV=1 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.31912 BP_3 3.00 0.38 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31915 BP_3 9.92 1.04 753 478255840 ENN76048.1 275 6.3e-22 hypothetical protein YQE_07421, partial [Dendroctonus ponderosae]>gi|546680467|gb|ERL90733.1| hypothetical protein D910_08080 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16692 Folliculin C-terminal domain GO:0043087 regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.31917 BP_3 63.78 0.87 3826 91083817 XP_973463.1 602 3.9e-59 PREDICTED: large neutral amino acids transporter small subunit 2 [Tribolium castaneum]>gi|270006773|gb|EFA03221.1| hypothetical protein TcasGA2_TC013142 [Tribolium castaneum] -- -- -- -- -- K13780 SLC7A5, LAT1 solute carrier family 7 (L-type amino acid transporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13780 Q01650 398 7.2e-37 Large neutral amino acids transporter small subunit 1 OS=Homo sapiens GN=SLC7A5 PE=1 SV=2 PF13520//PF03222//PF00324 Amino acid permease//Tryptophan/tyrosine permease family//Amino acid permease GO:0006865//GO:0055085//GO:0003333//GO:0006810 amino acid transport//transmembrane transport//amino acid transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1287 Amino acid transporters Cluster-8309.31918 BP_3 5.00 0.59 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31919 BP_3 69.74 47.73 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00719 Inorganic pyrophosphatase GO:0006796//GO:0006119 phosphate-containing compound metabolic process//oxidative phosphorylation GO:0004427//GO:0000287 inorganic diphosphatase activity//magnesium ion binding GO:0005737 cytoplasm -- -- Cluster-8309.31920 BP_3 41.26 1.59 1544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31923 BP_3 1623.50 10.44 7788 189241335 XP_001809545.1 1796 2.8e-197 PREDICTED: innexin inx3 [Tribolium castaneum]>gi|270013143|gb|EFA09591.1| hypothetical protein TcasGA2_TC011709 [Tribolium castaneum] 642936310 XM_001809493.2 416 0 PREDICTED: Tribolium castaneum innexin inx3 (LOC100141896), mRNA -- -- -- -- Q9VAS7 1318 3.1e-143 Innexin inx3 OS=Drosophila melanogaster GN=Inx3 PE=1 SV=1 PF06662//PF01292//PF00876 D-glucuronyl C5-epimerase C-terminus//Prokaryotic cytochrome b561//Innexin GO:0006024//GO:0006118 glycosaminoglycan biosynthetic process//obsolete electron transport GO:0016857//GO:0009055 racemase and epimerase activity, acting on carbohydrates and derivatives//electron carrier activity GO:0005921//GO:0016021 gap junction//integral component of membrane -- -- Cluster-8309.31924 BP_3 2332.56 35.28 3478 642938660 XP_972301.2 1732 3.3e-190 PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum]>gi|642938662|ref|XP_008197697.1| PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum]>gi|642938664|ref|XP_008197706.1| PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00819 rocD, OAT ornithine--oxo-acid transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00819 Q9VW26 1401 3.3e-153 Ornithine aminotransferase, mitochondrial OS=Drosophila melanogaster GN=Oat PE=2 SV=1 PF00202 Aminotransferase class-III -- -- GO:0008483//GO:0030170 transaminase activity//pyridoxal phosphate binding -- -- KOG1402 Ornithine aminotransferase Cluster-8309.31925 BP_3 548.78 11.38 2616 189238377 XP_001808976.1 1154 2.6e-123 PREDICTED: uncharacterized protein LOC100141756 [Tribolium castaneum]>gi|270008562|gb|EFA05010.1| hypothetical protein TcasGA2_TC015091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31926 BP_3 274.62 2.81 4995 91084129 XP_969781.1 3731 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 75 4.61528e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1271 5.6e-138 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF01926//PF13304//PF07728//PF02456//PF00005//PF03193//PF06552 ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//AAA domain (dynein-related subfamily)//Adenovirus IVa2 protein//ABC transporter//Protein of unknown function, DUF258//Plant specific mitochondrial import receptor subunit TOM20 GO:0045040//GO:0009987//GO:0019083//GO:0055085//GO:0006810 protein import into mitochondrial outer membrane//cellular process//viral transcription//transmembrane transport//transport GO:0005525//GO:0000166//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//nucleotide binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane -- -- Cluster-8309.31931 BP_3 2.76 0.36 656 642917231 XP_008191173.1 324 1.1e-27 PREDICTED: thioredoxin reductase 2, mitochondrial isoform X2 [Tribolium castaneum] 195396538 XM_002056853.1 42 1.28076e-10 Drosophila virilis GJ16646 (Dvir\GJ16646), mRNA K00384 trxB thioredoxin reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00384 Q9NNW7 244 8.9e-20 Thioredoxin reductase 2, mitochondrial OS=Homo sapiens GN=TXNRD2 PE=1 SV=3 PF01266//PF05834//PF00070//PF01134//PF07992//PF01494//PF00106//PF12831 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//short chain dehydrogenase//FAD dependent oxidoreductase GO:0016117//GO:0055114//GO:0008033//GO:0008152 carotenoid biosynthetic process//oxidation-reduction process//tRNA processing//metabolic process GO:0050660//GO:0016705//GO:0071949//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oxidoreductase activity -- -- KOG4716 Thioredoxin reductase Cluster-8309.31932 BP_3 566.30 3.81 7452 642917231 XP_008191173.1 2074 1.6e-229 PREDICTED: thioredoxin reductase 2, mitochondrial isoform X2 [Tribolium castaneum] 195396538 XM_002056853.1 42 1.52538e-09 Drosophila virilis GJ16646 (Dvir\GJ16646), mRNA K00384 trxB thioredoxin reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00384 P91938 1574 6.1e-173 Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 PE=1 SV=2 PF12831//PF00106//PF01494//PF02852//PF07992//PF01296//PF01134//PF02558//PF04369//PF00070//PF06268//PF01979//PF03435//PF01266//PF05699 FAD dependent oxidoreductase//short chain dehydrogenase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//Pyridine nucleotide-disulphide oxidoreductase//Galanin//Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//Lactococcin-like family//Pyridine nucleotide-disulphide oxidoreductase//Fascin domain//Amidohydrolase family//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//hAT family C-terminal dimerisation region GO:0055114//GO:0008033//GO:0007165//GO:0015940//GO:0042742//GO:0045454//GO:0008152 oxidation-reduction process//tRNA processing//signal transduction//pantothenate biosynthetic process//defense response to bacterium//cell redox homeostasis//metabolic process GO:0051015//GO:0071949//GO:0016787//GO:0030674//GO:0050660//GO:0008677//GO:0046983//GO:0005179//GO:0016491 actin filament binding//FAD binding//hydrolase activity//protein binding, bridging//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//protein dimerization activity//hormone activity//oxidoreductase activity GO:0005576 extracellular region KOG4716 Thioredoxin reductase Cluster-8309.31933 BP_3 53.32 0.35 7645 642917231 XP_008191173.1 1402 1.3e-151 PREDICTED: thioredoxin reductase 2, mitochondrial isoform X2 [Tribolium castaneum] 195396538 XM_002056853.1 42 1.56508e-09 Drosophila virilis GJ16646 (Dvir\GJ16646), mRNA K00384 trxB thioredoxin reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00384 P91938 995 8.6e-106 Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 PE=1 SV=2 PF02826//PF00070//PF04369//PF01134//PF01979//PF03435//PF05699//PF01266//PF13241//PF06268//PF12831//PF01296//PF07992//PF00106//PF01494 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Lactococcin-like family//Glucose inhibited division protein A//Amidohydrolase family//Saccharopine dehydrogenase NADP binding domain//hAT family C-terminal dimerisation region//FAD dependent oxidoreductase//Putative NAD(P)-binding//Fascin domain//FAD dependent oxidoreductase//Galanin//Pyridine nucleotide-disulphide oxidoreductase//short chain dehydrogenase//FAD binding domain GO:0008152//GO:0019354//GO:0042742//GO:0007165//GO:0006779//GO:0008033//GO:0055114 metabolic process//siroheme biosynthetic process//defense response to bacterium//signal transduction//porphyrin-containing compound biosynthetic process//tRNA processing//oxidation-reduction process GO:0043115//GO:0016491//GO:0051287//GO:0046983//GO:0005179//GO:0050660//GO:0030674//GO:0016787//GO:0071949//GO:0051015 precorrin-2 dehydrogenase activity//oxidoreductase activity//NAD binding//protein dimerization activity//hormone activity//flavin adenine dinucleotide binding//protein binding, bridging//hydrolase activity//FAD binding//actin filament binding GO:0005576 extracellular region KOG4716 Thioredoxin reductase Cluster-8309.31936 BP_3 1030.80 11.93 4457 546681097 ERL91253.1 2497 8.3e-279 hypothetical protein D910_08588 [Dendroctonus ponderosae] 820837626 XM_003690680.2 92 1.45907e-37 PREDICTED: Apis florea syntaxin-5 (LOC100868396), mRNA -- -- -- -- Q24179 2001 1.1e-222 Protein sly1 homolog OS=Drosophila melanogaster GN=Slh PE=2 SV=4 PF16519//PF00804//PF00995//PF05739//PF08131//PF00992 Tetramerisation domain of TRPM//Syntaxin//Sec1 family//SNARE domain//Defensin-like peptide family//Troponin GO:0051262//GO:0016192//GO:0006904 protein tetramerization//vesicle-mediated transport//vesicle docking involved in exocytosis GO:0005515 protein binding GO:0016020//GO:0005576//GO:0005861 membrane//extracellular region//troponin complex KOG1301 Vesicle trafficking protein Sly1 (Sec1 family) Cluster-8309.31937 BP_3 636.79 8.06 4102 642925014 XP_008194135.1 4669 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X5 [Tribolium castaneum] 759033714 XM_011331771.1 146 1.28614e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X2, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3858 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03293//PF15014//PF03485//PF05236//PF03540 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Ceroid-lipofuscinosis neuronal protein 5//Arginyl tRNA synthetase N terminal domain//Transcription initiation factor TFIID component TAF4 family//Transcription initiation factor TFIID 23-30kDa subunit GO:0006420//GO:0006525//GO:0019083//GO:0022008//GO:0006206//GO:0006352//GO:0006351//GO:0006144//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//viral transcription//neurogenesis//pyrimidine nucleobase metabolic process//DNA-templated transcription, initiation//transcription, DNA-templated//purine nucleobase metabolic process//proline metabolic process GO:0000166//GO:0005524//GO:0003899//GO:0003677//GO:0004814 nucleotide binding//ATP binding//DNA-directed RNA polymerase activity//DNA binding//arginine-tRNA ligase activity GO:0005764//GO:0005669//GO:0005730//GO:0005737//GO:0005634 lysosome//transcription factor TFIID complex//nucleolus//cytoplasm//nucleus KOG3635 Phosphorylase kinase Cluster-8309.31939 BP_3 3496.00 72.25 2624 91078628 XP_966496.1 2433 1.3e-271 PREDICTED: septin-7 [Tribolium castaneum]>gi|270004061|gb|EFA00509.1| hypothetical protein TcasGA2_TC003373 [Tribolium castaneum] 508228 U08103.1 245 7.57868e-123 DMU08103 Drosophila melanogaster Peanut (pnut) mRNA, complete cds K16944 SEPT7, CDC3 septin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K16944 P40797 1589 3.9e-175 Protein peanut OS=Drosophila melanogaster GN=pnut PE=1 SV=2 PF03193//PF00735//PF00005//PF01926//PF10186//PF04548//PF00071 Protein of unknown function, DUF258//Septin//ABC transporter//50S ribosome-binding GTPase//Vacuolar sorting 38 and autophagy-related subunit 14//AIG1 family//Ras family GO:0010508//GO:0007264//GO:0007049 positive regulation of autophagy//small GTPase mediated signal transduction//cell cycle GO:0003924//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ATP binding//GTP binding//ATPase activity -- -- KOG2655 Septin family protein (P-loop GTPase) Cluster-8309.31942 BP_3 716.73 7.69 4786 189237113 XP_971629.2 1209 2.0e-129 PREDICTED: xyloside xylosyltransferase 1 [Tribolium castaneum]>gi|270007231|gb|EFA03679.1| hypothetical protein TcasGA2_TC013781 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBI6 600 3.4e-60 Xyloside xylosyltransferase 1 OS=Homo sapiens GN=XXYLT1 PE=1 SV=1 PF13499//PF13405//PF13833//PF00036//PF12763//PF13202 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0016757//GO:0005509//GO:0005515 transferase activity, transferring glycosyl groups//calcium ion binding//protein binding -- -- KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.31944 BP_3 38285.00 5454.56 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.31946 BP_3 173.67 4.66 2089 189233943 XP_974086.2 1977 7.7e-219 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R5X9 220 1.7e-16 SET and MYND domain-containing protein 4 OS=Pongo abelii GN=SMYD4 PE=2 SV=1 PF00856//PF13414//PF13181 SET domain//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.31948 BP_3 296.37 7.98 2081 478256367 ENN76557.1 2591 4.9e-290 hypothetical protein YQE_07008, partial [Dendroctonus ponderosae] -- -- -- -- -- K10455 KLHL18 kelch-like protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K10455 O94889 1471 1.5e-161 Kelch-like protein 18 OS=Homo sapiens GN=KLHL18 PE=1 SV=3 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.31949 BP_3 218.24 3.17 3611 642936594 XP_008198499.1 1421 3.9e-154 PREDICTED: solute carrier family 2, facilitated glucose transporter member 1-like isoform X2 [Tribolium castaneum]>gi|270014149|gb|EFA10597.1| hypothetical protein TcasGA2_TC012857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13355 670 2.0e-68 Solute carrier family 2, facilitated glucose transporter member 1 OS=Oryctolagus cuniculus GN=SLC2A1 PE=2 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.31951 BP_3 9.82 1.12 715 642922046 XP_008192998.1 213 9.3e-15 PREDICTED: lysosome-associated membrane glycoprotein 1, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11857//PF01299 Domain of unknown function (DUF3377)//Lysosome-associated membrane glycoprotein (Lamp) -- -- GO:0004222 metalloendopeptidase activity GO:0016020 membrane -- -- Cluster-8309.31952 BP_3 6.00 0.70 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31954 BP_3 74.43 0.55 6797 642920318 XP_008192297.1 1522 1.4e-165 PREDICTED: uncharacterized protein LOC664527 isoform X1 [Tribolium castaneum] 642920319 XM_008194076.1 157 1.64084e-73 PREDICTED: Tribolium castaneum uncharacterized LOC664527 (LOC664527), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00646//PF01429//PF12937//PF13855 F-box domain//Methyl-CpG binding domain//F-box-like//Leucine rich repeat -- -- GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.31955 BP_3 125.97 2.09 3193 546681102 ERL91258.1 1088 1.4e-115 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P34410 177 2.6e-11 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF01573 Bromovirus movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0044156 host cell junction -- -- Cluster-8309.31957 BP_3 472.43 7.22 3447 642933985 XP_008197592.1 1968 1.4e-217 PREDICTED: histone acetyltransferase KAT6A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3YXK1 194 2.9e-13 Atherin OS=Mus musculus GN=Samd1 PE=1 SV=1 PF00628//PF16866//PF02198//PF05715//PF13639//PF00536 PHD-finger//PHD-finger//Sterile alpha motif (SAM)/Pointed domain//Piccolo Zn-finger//Ring finger domain//SAM domain (Sterile alpha motif) -- -- GO:0043565//GO:0008270//GO:0046872//GO:0005515 sequence-specific DNA binding//zinc ion binding//metal ion binding//protein binding GO:0005634//GO:0045202 nucleus//synapse -- -- Cluster-8309.31958 BP_3 474.38 4.61 5256 642914506 XP_008201705.1 1739 7.7e-191 PREDICTED: protein RUFY3 isoform X4 [Tribolium castaneum]>gi|270001486|gb|EEZ97933.1| hypothetical protein TcasGA2_TC000321 [Tribolium castaneum] 749749484 XM_011138657.1 86 3.72914e-34 PREDICTED: Harpegnathos saltator protein RUFY3 (LOC105181701), transcript variant X2, mRNA -- -- -- -- Q5R5R4 925 7.7e-98 RUN and FYVE domain-containing protein 2 OS=Pongo abelii GN=RUFY2 PE=2 SV=1 PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.3196 BP_3 5.00 0.47 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31961 BP_3 158.85 8.69 1173 642927772 XP_008195399.1 282 1.5e-22 PREDICTED: receptor-type tyrosine-protein phosphatase F-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MBJ4 165 2.3e-10 Receptor-type tyrosine-protein phosphatase F OS=Bos taurus GN=PTPRF PE=2 SV=1 PF16656//PF00041//PF03425 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Carbohydrate binding domain (family 11) GO:0019497//GO:0005982//GO:0005985//GO:0030245//GO:0006771 hexachlorocyclohexane metabolic process//starch metabolic process//sucrose metabolic process//cellulose catabolic process//riboflavin metabolic process GO:0005515//GO:0008810//GO:0046872//GO:0003993 protein binding//cellulase activity//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-8309.31962 BP_3 9.00 2.62 457 642927770 XP_008195398.1 146 3.5e-07 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31963 BP_3 85.77 0.83 5278 665804096 XP_008550173.1 2041 7.4e-226 PREDICTED: potassium voltage-gated channel protein Shab isoform X2 [Microplitis demolitor] 189008483 EU616810.1 323 6.6967e-166 Tribolium castaneum shaker cognate b (Shab) gene, exon 2 and partial cds K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1859 3.9e-206 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF13374//PF01092//PF00520//PF00060//PF02214 Tetratricopeptide repeat//Ribosomal protein S6e//Ion transport protein//Ligand-gated ion channel//BTB/POZ domain GO:0055085//GO:0007165//GO:0006412//GO:0051260//GO:0007268//GO:0006811//GO:0042254 transmembrane transport//signal transduction//translation//protein homooligomerization//synaptic transmission//ion transport//ribosome biogenesis GO:0005515//GO:0004970//GO:0005216//GO:0003735 protein binding//ionotropic glutamate receptor activity//ion channel activity//structural constituent of ribosome GO:0016020//GO:0005622//GO:0005840 membrane//intracellular//ribosome -- -- Cluster-8309.31966 BP_3 415.00 11.59 2017 91086887 XP_970325.1 1279 6.4e-138 PREDICTED: dnaJ homolog subfamily C member 21 [Tribolium castaneum]>gi|270010477|gb|EFA06925.1| hypothetical protein TcasGA2_TC009874 [Tribolium castaneum] 690018598 LM525836.1 44 3.15391e-11 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_contig0000215 K09506 DNAJA5 DnaJ homolog subfamily A member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09506 Q5F1R6 873 3.2e-92 DnaJ homolog subfamily C member 21 OS=Homo sapiens GN=DNAJC21 PE=1 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- KOG0717 Molecular chaperone (DnaJ superfamily) Cluster-8309.31967 BP_3 2004.23 41.63 2612 91085817 XP_974784.1 2646 2.6e-296 PREDICTED: peroxisomal multifunctional enzyme type 2 isoform X1 [Tribolium castaneum]>gi|270011047|gb|EFA07495.1| hydroxysteroid (17-beta) dehydrogenase 4 [Tribolium castaneum] 642927307 XM_008196993.1 99 1.09277e-41 PREDICTED: Tribolium castaneum hydroxysteroid (17-beta) dehydrogenase 4 (LOC663655), transcript variant X2, mRNA K12405 HSD17B4 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K12405 Q9VXJ0 1734 6.0e-192 Peroxisomal multifunctional enzyme type 2 OS=Drosophila melanogaster GN=Mfe2 PE=1 SV=1 PF02737//PF00106 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//short chain dehydrogenase GO:0006568//GO:0006631//GO:0006552//GO:0006554//GO:0055114//GO:0006574//GO:0006550//GO:0008152//GO:0018874//GO:0006633 tryptophan metabolic process//fatty acid metabolic process//leucine catabolic process//lysine catabolic process//oxidation-reduction process//valine catabolic process//isoleucine catabolic process//metabolic process//benzoate metabolic process//fatty acid biosynthetic process GO:0003857//GO:0000166//GO:0032934//GO:0016491 3-hydroxyacyl-CoA dehydrogenase activity//nucleotide binding//sterol binding//oxidoreductase activity -- -- KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes Cluster-8309.31968 BP_3 1599.65 18.94 4363 642921136 XP_008192702.1 1068 4.1e-113 PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921138|ref|XP_008192703.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921140|ref|XP_008192704.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921142|ref|XP_008192706.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921144|ref|XP_008192707.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921146|ref|XP_008192708.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921148|ref|XP_008192709.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921150|ref|XP_008192710.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WVB4 224 1.2e-16 Slit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2 PF13895//PF14991//PF15050//PF13855 Immunoglobulin domain//Protein melan-A//SCIMP protein//Leucine rich repeat -- -- GO:0005515 protein binding GO:0016021//GO:0001772//GO:0042470//GO:0097197 integral component of membrane//immunological synapse//melanosome//tetraspanin-enriched microdomain -- -- Cluster-8309.31971 BP_3 912.77 8.60 5408 91094249 XP_968795.1 1078 3.5e-114 PREDICTED: neurofilament heavy polypeptide [Tribolium castaneum]>gi|270016266|gb|EFA12712.1| hypothetical protein TcasGA2_TC002346 [Tribolium castaneum] -- -- -- -- -- K00653 CDY chromodomain protein Y http://www.genome.jp/dbget-bin/www_bget?ko:K00653 Q9D5D8 286 9.9e-24 Chromodomain Y-like protein 2 OS=Mus musculus GN=Cdyl2 PE=1 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG0016 Enoyl-CoA hydratase/isomerase Cluster-8309.31972 BP_3 212.00 5.92 2017 478254874 ENN75110.1 805 5.9e-83 hypothetical protein YQE_08423, partial [Dendroctonus ponderosae] -- -- -- -- -- K07573 CSL4, EXOSC1 exosome complex component CSL4 http://www.genome.jp/dbget-bin/www_bget?ko:K07573 Q9DAA6 489 1.1e-47 Exosome complex component CSL4 OS=Mus musculus GN=Exosc1 PE=2 SV=1 PF10447 Exosome component EXOSC1/CSL4 -- -- GO:0003723 RNA binding GO:0000178 exosome (RNase complex) KOG3409 Exosomal 3'-5' exoribonuclease complex, subunit ski4 (Csl4) Cluster-8309.31975 BP_3 1734.14 23.19 3896 642921248 XP_969543.2 1439 3.5e-156 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 O75420 250 1.1e-19 PERQ amino acid-rich with GYF domain-containing protein 1 OS=Homo sapiens GN=GIGYF1 PE=1 SV=2 PF02213 GYF domain -- -- GO:0005515 protein binding -- -- KOG1862 GYF domain containing proteins Cluster-8309.31977 BP_3 35.30 0.75 2565 270003285 EEZ99732.1 1425 9.6e-155 hypothetical protein TcasGA2_TC002501 [Tribolium castaneum] 780625043 XM_011709899.1 203 1.64912e-99 PREDICTED: Wasmannia auropunctata CCR4-NOT transcription complex subunit 3 (LOC105462953), mRNA K12580 CNOT3, NOT3 CCR4-NOT transcription complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12580 O75175 858 2.2e-90 CCR4-NOT transcription complex subunit 3 OS=Homo sapiens GN=CNOT3 PE=1 SV=1 PF04065//PF07352//PF04153 Not1 N-terminal domain, CCR4-Not complex component//Bacteriophage Mu Gam like protein//NOT2 / NOT3 / NOT5 family GO:0006355//GO:0042262 regulation of transcription, DNA-templated//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG2150 CCR4-NOT transcriptional regulation complex, NOT5 subunit Cluster-8309.31978 BP_3 292.18 5.65 2784 270012236 EFA08684.1 956 2.5e-100 hypothetical protein TcasGA2_TC006354 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVV5 418 2.5e-39 Androgen-induced gene 1 protein OS=Homo sapiens GN=AIG1 PE=1 SV=2 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.31979 BP_3 538.09 16.93 1824 91088493 XP_975965.1 800 2.0e-82 PREDICTED: androgen-induced gene 1 protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVV5 420 9.7e-40 Androgen-induced gene 1 protein OS=Homo sapiens GN=AIG1 PE=1 SV=2 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.31980 BP_3 432.71 18.73 1405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04210 Tetrahydromethanopterin S-methyltransferase, subunit G GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.31981 BP_3 114.00 7.28 1047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31983 BP_3 387.48 7.30 2851 642937018 XP_008198655.1 2482 2.9e-277 PREDICTED: neutral ceramidase-like [Tribolium castaneum] -- -- -- -- -- K12349 ASAH2 neutral ceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K12349 Q9VA70 1845 8.8e-205 Neutral ceramidase OS=Drosophila melanogaster GN=CDase PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2232 Ceramidases Cluster-8309.31984 BP_3 157.66 1.18 6751 91090364 XP_968231.1 1148 3.3e-122 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18459 587 1.5e-58 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00097//PF14634//PF11789//PF04728//PF01363//PF02891//PF00351//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Zinc-finger of the MIZ type in Nse subunit//Lipoprotein leucine-zipper//FYVE zinc finger//MIZ/SP-RING zinc finger//Biopterin-dependent aromatic amino acid hydroxylase//Ring finger domain GO:0055114 oxidation-reduction process GO:0005515//GO:0046872//GO:0008270//GO:0016714 protein binding//metal ion binding//zinc ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0019867 outer membrane KOG3820 Aromatic amino acid hydroxylase Cluster-8309.31985 BP_3 835.38 6.78 6228 91090364 XP_968231.1 1683 2.8e-184 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5U6 614 1.1e-61 RING finger protein 10 OS=Homo sapiens GN=RNF10 PE=1 SV=2 PF13639//PF00351//PF04728//PF00097//PF02891//PF14634 Ring finger domain//Biopterin-dependent aromatic amino acid hydroxylase//Lipoprotein leucine-zipper//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger//zinc-RING finger domain GO:0055114 oxidation-reduction process GO:0016714//GO:0008270//GO:0005515//GO:0046872 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//zinc ion binding//protein binding//metal ion binding GO:0019867 outer membrane KOG2164 Predicted E3 ubiquitin ligase Cluster-8309.31986 BP_3 200.00 8.44 1434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31987 BP_3 133.00 8.79 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31988 BP_3 312.37 1.90 8204 817053828 XP_012264100.1 1826 9.8e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935876 XR_511652.1 647 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X4, misc_RNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 Q9UBE8 1597 1.4e-175 Serine/threonine-protein kinase NLK OS=Homo sapiens GN=NLK PE=1 SV=2 PF06293//PF00069//PF07714//PF04505 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Interferon-induced transmembrane protein GO:0009607//GO:0006468 response to biotic stimulus//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.31989 BP_3 5.61 0.47 869 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.31990 BP_3 36.00 0.69 2813 270003816 EFA00264.1 191 1.3e-11 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF02176//PF13465//PF00096 C2H2-type zinc finger//TRAF-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.31991 BP_3 1744.00 18.63 4803 91084227 XP_969046.1 2331 1.6e-259 PREDICTED: uncharacterized protein LOC657496 [Tribolium castaneum]>gi|270009271|gb|EFA05719.1| egalitarian [Tribolium castaneum] 391343176 XM_003745841.1 42 9.80954e-10 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100902998 (LOC100902998), mRNA K18740 EXD1, EGL exonuclease 3'-5' domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18740 Q6NRD5 136 2.2e-06 Exonuclease 3'-5' domain-containing protein 1 OS=Xenopus laevis GN=exd1 PE=2 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- KOG2405 Predicted 3'-5' exonuclease Cluster-8309.31992 BP_3 2757.01 72.60 2122 91087227 XP_975491.1 2614 1.1e-292 PREDICTED: probable nucleolar GTP-binding protein 1 [Tribolium castaneum]>gi|270009559|gb|EFA06007.1| hypothetical protein TcasGA2_TC008833 [Tribolium castaneum] 820858813 XM_012490940.1 361 0 PREDICTED: Apis florea probable nucleolar GTP-binding protein 1 (LOC100863188), transcript variant X2, mRNA K06943 NOG1 nucleolar GTP-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K06943 Q9V411 2299 1.5e-257 Probable nucleolar GTP-binding protein 1 OS=Drosophila melanogaster GN=CG8801 PE=2 SV=1 PF02421//PF04548//PF06858//PF01926//PF08063//PF03193//PF08477 Ferrous iron transport protein B//AIG1 family//Nucleolar GTP-binding protein 1 (NOG1)//50S ribosome-binding GTPase//PADR1 (NUC008) domain//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0042254//GO:0007264//GO:0015684 ribosome biogenesis//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0003950//GO:0015093//GO:0003924 GTP binding//NAD+ ADP-ribosyltransferase activity//ferrous iron transmembrane transporter activity//GTPase activity GO:0005730//GO:0016021//GO:0005634 nucleolus//integral component of membrane//nucleus KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily) Cluster-8309.31993 BP_3 8669.69 98.04 4554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31994 BP_3 4608.31 114.54 2231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31995 BP_3 2750.96 111.87 1477 189238011 XP_001813334.1 454 2.2e-42 PREDICTED: SH3 domain-binding glutamic acid-rich protein homolog [Tribolium castaneum]>gi|270008052|gb|EFA04500.1| hypothetical protein TcasGA2_TC014808 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NFP5 386 6.9e-36 SH3 domain-binding glutamic acid-rich protein homolog OS=Drosophila melanogaster GN=Sh3beta PE=1 SV=2 PF02932//PF00462 Neurotransmitter-gated ion-channel transmembrane region//Glutaredoxin GO:0006118//GO:0045454//GO:0006811 obsolete electron transport//cell redox homeostasis//ion transport GO:0009055//GO:0015035 electron carrier activity//protein disulfide oxidoreductase activity GO:0016020 membrane KOG4023 Uncharacterized conserved protein Cluster-8309.31996 BP_3 1017.18 13.19 4008 642930846 XP_008196111.1 677 8.2e-68 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31997 BP_3 53.46 2.91 1176 270015668 EFA12116.1 318 1.0e-26 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- K11162 RDH14 retinol dehydrogenase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11162 Q9HBH5 203 9.1e-15 Retinol dehydrogenase 14 OS=Homo sapiens GN=RDH14 PE=1 SV=1 PF00106//PF01733 short chain dehydrogenase//Nucleoside transporter GO:0006810//GO:0008152//GO:0015858 transport//metabolic process//nucleoside transport GO:0005337//GO:0016491 nucleoside transmembrane transporter activity//oxidoreductase activity GO:0016021 integral component of membrane KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.31999 BP_3 28.00 0.93 1746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32 BP_3 57.83 2.39 1457 831314739 XP_012689951.1 272 2.7e-21 PREDICTED: protein-tyrosine kinase 6-like [Clupea harengus] -- -- -- -- -- -- -- -- -- O08680 258 4.7e-21 Ephrin type-A receptor 3 OS=Rattus norvegicus GN=Epha3 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.3200 BP_3 2.50 0.66 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32000 BP_3 59.00 0.78 3926 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32002 BP_3 160.75 3.18 2729 642934848 XP_008197836.1 1564 7.8e-171 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JR59 239 1.4e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32003 BP_3 1227.82 14.26 4442 642928339 XP_008195541.1 872 2.2e-90 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog-like isoform X1 [Tribolium castaneum] 571531697 XM_006570187.1 53 6.95955e-16 PREDICTED: Apis mellifera synaptic vesicle membrane protein VAT-1 homolog-like (LOC409207), mRNA -- -- -- -- Q80TB8 598 5.4e-60 Synaptic vesicle membrane protein VAT-1 homolog-like OS=Mus musculus GN=Vat1l PE=2 SV=2 PF06213//PF05038//PF06459//PF10152//PF01080//PF03286//PF00951//PF05132 Cobalamin biosynthesis protein CobT//Cytochrome Cytochrome b558 alpha-subunit//Ryanodine Receptor TM 4-6//Predicted coiled-coil domain-containing protein (DUF2360)//Presenilin//Pox virus Ag35 surface protein//Arterivirus GL envelope glycoprotein//RNA polymerase III RPC4 GO:0006874//GO:0009236//GO:0006816//GO:0006206//GO:0006144//GO:0006383//GO:0006351 cellular calcium ion homeostasis//cobalamin biosynthetic process//calcium ion transport//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated GO:0003899//GO:0020037//GO:0005219//GO:0004190//GO:0003677 DNA-directed RNA polymerase activity//heme binding//ryanodine-sensitive calcium-release channel activity//aspartic-type endopeptidase activity//DNA binding GO:0071203//GO:0005730//GO:0005666//GO:0005622//GO:0016021//GO:0019031 WASH complex//nucleolus//DNA-directed RNA polymerase III complex//intracellular//integral component of membrane//viral envelope -- -- Cluster-8309.32005 BP_3 53.64 1.65 1861 642917912 XP_008191379.1 813 6.4e-84 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GLD9 394 1.0e-36 UDP-glucuronosyltransferase 2B33 OS=Macaca mulatta GN=UGT2B33 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.32006 BP_3 23.01 0.73 1811 189239791 XP_001811527.1 819 1.3e-84 PREDICTED: oxysterol-binding protein 1 isoform X2 [Tribolium castaneum] 642930859 XM_001811475.2 182 5.46275e-88 PREDICTED: Tribolium castaneum oxysterol-binding protein 1 (LOC657071), transcript variant X2, mRNA -- -- -- -- P16258 520 2.4e-51 Oxysterol-binding protein 1 OS=Oryctolagus cuniculus GN=OSBP PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1737 Oxysterol-binding protein Cluster-8309.32007 BP_3 512.45 16.50 1789 332374316 AEE62299.1 1062 8.3e-113 unknown [Dendroctonus ponderosae]>gi|478255157|gb|ENN75386.1| hypothetical protein YQE_07938, partial [Dendroctonus ponderosae]>gi|546677194|gb|ERL88076.1| hypothetical protein D910_05465 [Dendroctonus ponderosae] 820849703 XM_003694070.2 155 5.51081e-73 PREDICTED: Apis florea cytochrome c-type heme lyase (LOC100866108), mRNA K01764 E4.4.1.17 cytochrome c heme-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01764 Q5F339 774 8.5e-81 Cytochrome c-type heme lyase OS=Gallus gallus GN=HCCS PE=2 SV=1 PF01265 Cytochrome c/c1 heme lyase GO:0015994 chlorophyll metabolic process GO:0004408 holocytochrome-c synthase activity GO:0005739 mitochondrion KOG3996 Holocytochrome c synthase/heme-lyase Cluster-8309.32008 BP_3 384.00 9.60 2220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32009 BP_3 334.91 3.86 4473 189235133 XP_966882.2 3252 0.0e+00 PREDICTED: EH domain-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270003802|gb|EFA00250.1| hypothetical protein TcasGA2_TC003079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDI1 547 4.5e-54 EH domain-binding protein 1 OS=Homo sapiens GN=EHBP1 PE=1 SV=3 PF05366//PF00307 Sarcolipin//Calponin homology (CH) domain -- -- GO:0005515//GO:0030234 protein binding//enzyme regulator activity GO:0016020 membrane -- -- Cluster-8309.32011 BP_3 70.94 1.31 2907 642934675 XP_008197763.1 2080 1.2e-230 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 556762122 XM_005976302.1 125 4.28539e-56 PREDICTED: Pantholops hodgsonii adenylate cyclase 1 (brain) (ADCY1), mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1448 9.7e-159 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556 cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.32014 BP_3 591.00 14.90 2203 642921888 XP_008192930.1 829 1.1e-85 PREDICTED: exosome component 10 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 367 1.6e-33 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF00570 HRDC domain -- -- GO:0003676 nucleic acid binding GO:0005622 intracellular KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.32016 BP_3 331.83 7.10 2544 390198530 AFL70632.1 2664 2.0e-298 putative hypoxia-inducible factor 1 beta [Callosobruchus maculatus] 820805517 KP147913.1 529 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1818 1.1e-201 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF00989//PF00010//PF08447 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.32017 BP_3 68.18 1.74 2175 91090182 XP_966481.1 1041 2.8e-110 PREDICTED: methenyltetrahydrofolate synthase domain-containing protein [Tribolium castaneum]>gi|270013764|gb|EFA10212.1| hypothetical protein TcasGA2_TC012407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M296 578 5.5e-58 Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens GN=MTHFSD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4410 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.32018 BP_3 212.00 2.48 4409 270014232 EFA10680.1 1855 2.3e-204 hypothetical protein TcasGA2_TC011653 [Tribolium castaneum] 642936472 XM_008200228.1 150 8.26635e-70 PREDICTED: Tribolium castaneum lysyl oxidase homolog 3 (LOC656295), mRNA K00280 LOXL2_3_4 lysyl oxidase-like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00280 Q9Z175 939 1.5e-99 Lysyl oxidase homolog 3 OS=Mus musculus GN=Loxl3 PE=2 SV=2 PF00111//PF01186//PF15494//PF00530 2Fe-2S iron-sulfur cluster binding domain//Lysyl oxidase//Scavenger receptor cysteine-rich domain//Scavenger receptor cysteine-rich domain GO:0055114//GO:0006118//GO:0007165 oxidation-reduction process//obsolete electron transport//signal transduction GO:0009055//GO:0051536//GO:0016641//GO:0005044//GO:0005507 electron carrier activity//iron-sulfur cluster binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//scavenger receptor activity//copper ion binding GO:0016020 membrane -- -- Cluster-8309.32019 BP_3 579.58 8.40 3616 642925776 XP_008201712.1 2315 8.5e-258 PREDICTED: solute carrier family 26 member 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 9.1e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.32021 BP_3 1245.11 17.38 3745 642910971 XP_008193488.1 686 6.9e-69 PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910973|ref|XP_008193489.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910975|ref|XP_008193490.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910977|ref|XP_008193491.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910979|ref|XP_008193492.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|270015145|gb|EFA11593.1| transforming acidic coiled-coil protein [Tribolium castaneum] -- -- -- -- -- K14281 TACC1 transforming acidic coiled-coil-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14281 O75410 289 3.1e-24 Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens GN=TACC1 PE=1 SV=2 PF07224//PF08702//PF12740 Chlorophyllase//Fibrinogen alpha/beta chain family//Chlorophyllase enzyme GO:0030168//GO:0051258//GO:0015994//GO:0015996//GO:0007165 platelet activation//protein polymerization//chlorophyll metabolic process//chlorophyll catabolic process//signal transduction GO:0005102//GO:0030674//GO:0047746 receptor binding//protein binding, bridging//chlorophyllase activity GO:0005577 fibrinogen complex -- -- Cluster-8309.32022 BP_3 36.79 0.98 2092 546685583 ERL95070.1 2353 1.9e-262 hypothetical protein D910_12340 [Dendroctonus ponderosae] 766942063 XM_011505379.1 266 1.27603e-134 PREDICTED: Ceratosolen solmsi marchali ubiquitin-like modifier-activating enzyme 1 (LOC105366815), mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 A3KMV5 1955 1.1e-217 Ubiquitin-like modifier-activating enzyme 1 OS=Bos taurus GN=UBA1 PE=2 SV=1 PF00899//PF02170//PF09162 ThiF family//PAZ domain//Tap, RNA-binding GO:0006406 mRNA export from nucleus GO:0008641//GO:0005515//GO:0003723 small protein activating enzyme activity//protein binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG2012 Ubiquitin activating enzyme UBA1 Cluster-8309.32024 BP_3 503.00 24.00 1302 332373766 AEE62024.1 978 3.3e-103 unknown [Dendroctonus ponderosae]>gi|546680371|gb|ERL90650.1| hypothetical protein D910_07997 [Dendroctonus ponderosae] -- -- -- -- -- K08964 mtnB methylthioribulose-1-phosphate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K08964 Q6NU29 827 4.4e-87 Methylthioribulose-1-phosphate dehydratase OS=Xenopus laevis GN=apip PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2631 Class II aldolase/adducin N-terminal domain protein Cluster-8309.32025 BP_3 405.86 4.52 4620 91077318 XP_974708.1 1200 2.1e-128 PREDICTED: mitochondrial folate transporter/carrier [Tribolium castaneum]>gi|270002089|gb|EEZ98536.1| hypothetical protein TcasGA2_TC001040 [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q95J75 880 1.1e-92 Mitochondrial folate transporter/carrier OS=Macaca fascicularis GN=SLC25A32 PE=2 SV=1 PF01150//PF04194 GDA1/CD39 (nucleoside phosphatase) family//Programmed cell death protein 2, C-terminal putative domain GO:0055085 transmembrane transport GO:0016787 hydrolase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG0764 Mitochondrial FAD carrier protein Cluster-8309.32027 BP_3 25.62 0.37 3667 229892267 NP_001153545.1 1380 2.3e-149 uncharacterized MFS-type transporter [Tribolium castaneum]>gi|270007334|gb|EFA03782.1| hypothetical protein TcasGA2_TC013893 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NT16 373 5.5e-34 MFS-type transporter SLC18B1 OS=Homo sapiens GN=SLC18B1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.32028 BP_3 120.28 1.29 4790 332374190 AEE62236.1 1087 2.8e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02967 RP-S2, MRPS2, rpsB small subunit ribosomal protein S2 http://www.genome.jp/dbget-bin/www_bget?ko:K02967 Q9Y399 684 6.2e-70 28S ribosomal protein S2, mitochondrial OS=Homo sapiens GN=MRPS2 PE=1 SV=1 PF00318//PF02558//PF01370//PF00106 Ribosomal protein S2//Ketopantoate reductase PanE/ApbA//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0042254//GO:0055114//GO:0015940//GO:0008152//GO:0006412 ribosome biogenesis//oxidation-reduction process//pantothenate biosynthetic process//metabolic process//translation GO:0008677//GO:0003735//GO:0003824//GO:0050662//GO:0016491 2-dehydropantoate 2-reductase activity//structural constituent of ribosome//catalytic activity//coenzyme binding//oxidoreductase activity GO:0005622//GO:0005840 intracellular//ribosome KOG1205 Predicted dehydrogenase Cluster-8309.32030 BP_3 27.09 0.65 2288 642931433 XP_008196581.1 268 1.2e-20 PREDICTED: uncharacterized protein LOC662685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00036//PF13833//PF05497 EF hand//EF-hand domain pair//Destabilase GO:0005975 carbohydrate metabolic process GO:0003796//GO:0005509 lysozyme activity//calcium ion binding -- -- -- -- Cluster-8309.32031 BP_3 444.00 9.10 2644 478252395 ENN72821.1 871 1.7e-90 hypothetical protein YQE_10624, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VWD4 350 1.8e-31 Probable RNA-binding protein CG14230 OS=Drosophila melanogaster GN=CG14230 PE=1 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.32032 BP_3 137.00 9.79 966 642921958 XP_008192961.1 701 3.2e-71 PREDICTED: histone deacetylase complex subunit SAP130 [Tribolium castaneum]>gi|642921960|ref|XP_008192962.1| PREDICTED: histone deacetylase complex subunit SAP130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32034 BP_3 55.71 1.99 1638 734641965 XP_010749894.1 426 4.3e-39 PREDICTED: zinc finger protein 135-like [Larimichthys crocea] -- -- -- -- -- -- -- -- -- Q6ZMW2 404 6.2e-38 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF13465//PF01363//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//FYVE zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.32035 BP_3 228.70 3.12 3829 642922280 XP_008193091.1 2505 8.4e-280 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.7e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- KOG3731 Sulfatases Cluster-8309.32037 BP_3 28.42 0.60 2588 91083675 XP_968367.1 1695 4.8e-186 PREDICTED: serine/threonine-protein kinase PINK1, mitochondrial [Tribolium castaneum]>gi|270006820|gb|EFA03268.1| hypothetical protein TcasGA2_TC013202 [Tribolium castaneum] -- -- -- -- -- K05688 PINK1 PTEN induced putative kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05688 Q9BXM7 680 9.8e-70 Serine/threonine-protein kinase PINK1, mitochondrial OS=Homo sapiens GN=PINK1 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG4158 BRPK/PTEN-induced protein kinase Cluster-8309.32038 BP_3 68.10 1.04 3443 307173098 EFN64217.1 811 2.0e-83 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 428 2.2e-40 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF04977//PF05485//PF13851//PF00619 Septum formation initiator//THAP domain//Growth-arrest specific micro-tubule binding//Caspase recruitment domain GO:0007049//GO:0042981//GO:0048870 cell cycle//regulation of apoptotic process//cell motility GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.32039 BP_3 12830.51 143.78 4593 307173098 EFN64217.1 1138 3.3e-121 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 568 1.7e-56 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF05485//PF04977//PF13851 THAP domain//Septum formation initiator//Growth-arrest specific micro-tubule binding GO:0048870//GO:0007049 cell motility//cell cycle GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.3204 BP_3 173.11 10.45 1090 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32041 BP_3 18.23 0.37 2661 -- -- -- -- -- 642926883 XM_967083.3 40 6.99243e-09 PREDICTED: Tribolium castaneum neuroblastoma, suppression of tumorigenicity 1 (LOC660885), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32043 BP_3 239.00 9.94 1451 347962987 XP_311155.4 166 5.3e-09 AGAP000005-PA [Anopheles gambiae str. PEST]>gi|333467412|gb|EAA06432.5| AGAP000005-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.32045 BP_3 463.97 4.99 4777 642919809 XP_008192077.1 4749 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X2 [Tribolium castaneum] 642919808 XM_008193855.1 775 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X2, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1894 3.1e-210 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF07714//PF00069//PF06293//PF05445 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.32046 BP_3 222.84 2.58 4456 642919813 XP_008192079.1 4516 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X4 [Tribolium castaneum] 642919812 XM_008193857.1 725 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X4, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1839 6.8e-204 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF07714//PF00069//PF06293//PF05445 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.32047 BP_3 85.98 0.90 4918 861599125 KMQ83546.1 366 1.2e-31 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF13404 Transposase//AsnC-type helix-turn-helix domain GO:0006355//GO:0015074//GO:0006313 regulation of transcription, DNA-templated//DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.32048 BP_3 34.11 0.36 4898 861599125 KMQ83546.1 571 2.0e-55 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-8309.32049 BP_3 627.50 7.02 4598 607362259 EZA56517.1 336 3.3e-28 hypothetical protein X777_03552 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32050 BP_3 106.52 3.21 1892 91079236 XP_970901.1 1361 1.9e-147 PREDICTED: tubulin-specific chaperone E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KS0 795 3.3e-83 Tubulin-specific chaperone E OS=Bos taurus GN=TBCE PE=2 SV=1 PF00564//PF13855 PB1 domain//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG3207 Beta-tubulin folding cofactor E Cluster-8309.32051 BP_3 156.00 12.14 911 332375248 AEE62765.1 1172 7.4e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 Q5ZK84 896 3.1e-95 Alcohol dehydrogenase [NADP(+)] OS=Gallus gallus GN=AKR1A1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.32053 BP_3 49.95 0.67 3883 642915807 XP_008200086.1 3638 0.0e+00 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 572308789 XM_006620141.1 286 1.81833e-145 PREDICTED: Apis dorsata WD repeat-containing protein 47-like (LOC102670854), mRNA -- -- -- -- Q8CGF6 964 1.7e-102 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.32054 BP_3 36.92 0.96 2143 642914025 XP_968806.3 2881 0.0e+00 PREDICTED: cullin-5 [Tribolium castaneum] 642914024 XM_963713.3 606 0 PREDICTED: Tribolium castaneum cullin-5 (LOC657244), mRNA K10612 CUL5 cullin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10612 Q93034 2226 4.4e-249 Cullin-5 OS=Homo sapiens GN=CUL5 PE=1 SV=4 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.32055 BP_3 778.56 14.57 2867 642914025 XP_968806.3 3744 0.0e+00 PREDICTED: cullin-5 [Tribolium castaneum] 642914024 XM_963713.3 763 0 PREDICTED: Tribolium castaneum cullin-5 (LOC657244), mRNA K10612 CUL5 cullin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10612 Q93034 2839 0.0e+00 Cullin-5 OS=Homo sapiens GN=CUL5 PE=1 SV=4 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.32056 BP_3 96.00 18.63 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32057 BP_3 412.00 19.77 1296 443732396 ELU17138.1 187 1.7e-11 hypothetical protein CAPTEDRAFT_92072 [Capitella teleta] -- -- -- -- -- -- -- -- -- O70210 198 3.8e-14 Chondroadherin OS=Rattus norvegicus GN=Chad PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.32058 BP_3 140.04 3.26 2363 91087517 XP_969270.1 1320 1.3e-142 PREDICTED: phosphatidylinositol glycan anchor biosynthesis class U protein [Tribolium castaneum]>gi|270010669|gb|EFA07117.1| hypothetical protein TcasGA2_TC010108 [Tribolium castaneum] -- -- -- -- -- K05293 PIGU phosphatidylinositol glycan, class U http://www.genome.jp/dbget-bin/www_bget?ko:K05293 Q9H490 702 2.5e-72 Phosphatidylinositol glycan anchor biosynthesis class U protein OS=Homo sapiens GN=PIGU PE=1 SV=3 PF06728 GPI transamidase subunit PIG-U GO:0006506 GPI anchor biosynthetic process -- -- GO:0044425//GO:0016021 membrane part//integral component of membrane KOG2552 Major facilitator superfamily permease - Cdc91p Cluster-8309.3206 BP_3 6.00 0.43 969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32060 BP_3 685.12 42.65 1066 546684932 ERL94514.1 976 4.6e-103 hypothetical protein D910_11791 [Dendroctonus ponderosae] -- -- -- -- -- K02884 RP-L19, MRPL19, rplS large subunit ribosomal protein L19 http://www.genome.jp/dbget-bin/www_bget?ko:K02884 Q9VHN6 822 1.4e-86 39S ribosomal protein L19, mitochondrial OS=Drosophila melanogaster GN=mRpL19 PE=2 SV=1 PF01245 Ribosomal protein L19 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1698 Mitochondrial/chloroplast ribosomal protein L19 Cluster-8309.32061 BP_3 1637.84 36.73 2441 91088839 XP_970745.1 1385 4.0e-150 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] 642932363 XM_965652.3 445 0 PREDICTED: Tribolium castaneum RNA-binding protein lark (LOC659335), mRNA K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q94901 914 6.8e-97 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF08777//PF16367//PF00076//PF00098 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc knuckle -- -- GO:0043169//GO:0003676//GO:1901363//GO:0008270//GO:0003723//GO:0097159 cation binding//nucleic acid binding//heterocyclic compound binding//zinc ion binding//RNA binding//organic cyclic compound binding -- -- KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-8309.32062 BP_3 23.00 1.26 1172 642928001 XP_008195479.1 1671 1.3e-183 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] 642928000 XM_008197257.1 464 0 PREDICTED: Tribolium castaneum neurexin-1 (LOC663759), mRNA -- -- -- -- Q9Y4C0 510 2.3e-50 Neurexin-3 OS=Homo sapiens GN=NRXN3 PE=1 SV=4 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.32063 BP_3 1693.13 21.72 4049 642920320 XP_008192298.1 2616 1.2e-292 PREDICTED: uncharacterized protein LOC664527 isoform X2 [Tribolium castaneum]>gi|270005259|gb|EFA01707.1| hypothetical protein TcasGA2_TC007283 [Tribolium castaneum] 642920319 XM_008194076.1 157 9.74372e-74 PREDICTED: Tribolium castaneum uncharacterized LOC664527 (LOC664527), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00646//PF01429//PF12937//PF00130 F-box domain//Methyl-CpG binding domain//F-box-like//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.32065 BP_3 21.06 0.49 2359 478252924 ENN73308.1 272 4.4e-21 hypothetical protein YQE_10072, partial [Dendroctonus ponderosae]>gi|546681601|gb|ERL91665.1| hypothetical protein D910_08993 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5S1U6 148 4.3e-08 Interferon-related developmental regulator 1 OS=Sus scrofa GN=IFRD1 PE=2 SV=1 PF04973 Nicotinamide mononucleotide transporter GO:0034258 nicotinamide riboside transport GO:0034257 nicotinamide riboside transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.32066 BP_3 383.00 11.19 1942 189237080 XP_969040.2 1869 2.4e-206 PREDICTED: E3 ubiquitin-protein ligase parkin [Tribolium castaneum] -- -- -- -- -- K04556 PARK2 parkin http://www.genome.jp/dbget-bin/www_bget?ko:K04556 Q9JK66 1007 8.8e-108 E3 ubiquitin-protein ligase parkin OS=Rattus norvegicus GN=Park2 PE=1 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0006 E3 ubiquitin-protein ligase (Parkin protein) Cluster-8309.32067 BP_3 1104.55 15.88 3644 297139749 NP_001171929.1 2729 8.5e-306 LMBR1 domain-containing protein 2 homolog [Tribolium castaneum]>gi|270013548|gb|EFA09996.1| hypothetical protein TcasGA2_TC012164 [Tribolium castaneum] 815824957 XM_012378416.1 68 2.61426e-24 PREDICTED: Linepithema humile LMBR1 domain-containing protein 2 homolog (LOC105678779), mRNA -- -- -- -- Q8MRQ4 1775 1.5e-196 LMBR1 domain-containing protein 2 homolog OS=Drosophila melanogaster GN=CG8135 PE=2 SV=2 PF14777//PF01852 Cilia BBSome complex subunit 10//START domain GO:0042384 cilium assembly GO:0008289 lipid binding GO:0016021//GO:0034464 integral component of membrane//BBSome KOG2296 Integral membrane protein Cluster-8309.32068 BP_3 2849.00 63.65 2449 270006421 EFA02869.1 1344 2.3e-145 serpin peptidase inhibitor 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2I7M9 309 9.7e-27 Serpin A3-2 OS=Bos taurus GN=SERPINA3-2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32069 BP_3 1.00 1.16 323 546686467 ERL95704.1 334 3.9e-29 hypothetical protein D910_00138, partial [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 270 4.2e-23 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32071 BP_3 31.82 1.28 1491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32073 BP_3 75.08 1.18 3348 270001532 EEZ97979.1 2452 1.0e-273 hypothetical protein TcasGA2_TC000374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61627 319 9.2e-28 Glutamate receptor ionotropic, delta-1 OS=Mus musculus GN=Grid1 PE=1 SV=2 PF07826//PF10613//PF00060 IMP cyclohydrolase-like protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006807//GO:0006811//GO:0007165//GO:0006188//GO:0006144//GO:0007268//GO:0006164 nitrogen compound metabolic process//ion transport//signal transduction//IMP biosynthetic process//purine nucleobase metabolic process//synaptic transmission//purine nucleotide biosynthetic process GO:0003937//GO:0005234//GO:0004970 IMP cyclohydrolase activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0042720//GO:0016020 mitochondrial inner membrane peptidase complex//membrane -- -- Cluster-8309.32074 BP_3 676.00 56.64 867 91085133 XP_969714.1 636 1.0e-63 PREDICTED: probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [Tribolium castaneum]>gi|270009297|gb|EFA05745.1| hypothetical protein TcasGA2_TC015691 [Tribolium castaneum] 815819816 XM_012375678.1 42 1.71522e-10 PREDICTED: Linepithema humile probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (LOC105677223), transcript variant X2, mRNA K11352 NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11352 Q9N2W7 347 1.3e-31 Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 OS=Caenorhabditis elegans GN=Y94H6A.8 PE=3 SV=2 PF05071//PF00387 NADH ubiquinone oxidoreductase subunit NDUFA12//Phosphatidylinositol-specific phospholipase C, Y domain GO:0006629//GO:0007165//GO:0046339//GO:0006120//GO:0009395//GO:0015992//GO:0035556//GO:0006118//GO:0006814//GO:0006744 lipid metabolic process//signal transduction//diacylglycerol metabolic process//mitochondrial electron transport, NADH to ubiquinone//phospholipid catabolic process//proton transport//intracellular signal transduction//obsolete electron transport//sodium ion transport//ubiquinone biosynthetic process GO:0004435//GO:0008137//GO:0009055 phosphatidylinositol phospholipase C activity//NADH dehydrogenase (ubiquinone) activity//electron carrier activity GO:0016020 membrane KOG3382 NADH:ubiquinone oxidoreductase, B17.2 subunit Cluster-8309.32075 BP_3 1871.41 17.43 5468 642913773 XP_008201155.1 5985 0.0e+00 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6H8H2 2020 8.6e-225 DENN domain-containing protein 4C OS=Mus musculus GN=Dennd4c PE=1 SV=1 PF02055//PF02861 O-Glycosyl hydrolase family 30//Clp amino terminal domain, pathogenicity island component GO:0006687//GO:0019538//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//protein metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity -- -- KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.32078 BP_3 477.60 9.72 2660 728418853 AIY68384.1 1994 1.0e-220 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 678 1.7e-69 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.3208 BP_3 5.00 1.06 519 859746458 XP_004737878.2 755 9.5e-78 PREDICTED: 40S ribosomal protein S14 [Mustela putorius furo] 675791485 XM_003829021.2 519 0 PREDICTED: Pan paniscus ribosomal protein S14 (RPS14), transcript variant X1, mRNA >gnl|BL_ORD_ID|21104180 PREDICTED: Pan troglodytes ribosomal protein S14 (RPS14), mRNA K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 P62263 710 6.5e-74 40S ribosomal protein S14 OS=Homo sapiens GN=RPS14 PE=1 SV=3 PF03423//PF00411 Carbohydrate binding domain (family 25)//Ribosomal protein S11 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:2001070 structural constituent of ribosome//starch binding GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-8309.32081 BP_3 33.00 4.59 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32082 BP_3 706.06 11.84 3167 91087321 XP_975587.1 918 7.3e-96 PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|642929809|ref|XP_008195985.1| PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|270009526|gb|EFA05974.1| hypothetical protein TcasGA2_TC008799 [Tribolium castaneum] 186969251 EU616728.1 55 3.82319e-17 Kryptolebias marmoratus R-ras3 mRNA, complete cds K07830 RRAS2, TC21 Ras-related protein R-Ras2 http://www.genome.jp/dbget-bin/www_bget?ko:K07830 P04388 727 4.2e-75 Ras-like protein 2 OS=Drosophila melanogaster GN=Ras64B PE=1 SV=2 PF08477//PF01926//PF02421//PF00025//PF03193//PF08469//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ferrous iron transport protein B//ADP-ribosylation factor family//Protein of unknown function, DUF258//Nucleoside triphosphatase I C-terminal//Gtr1/RagA G protein conserved region//Ras family GO:0006351//GO:0015684//GO:0007264//GO:0006184 transcription, DNA-templated//ferrous iron transport//small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005524//GO:0015093//GO:0017111//GO:0005525 GTPase activity//ATP binding//ferrous iron transmembrane transporter activity//nucleoside-triphosphatase activity//GTP binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0395 Ras-related GTPase Cluster-8309.32083 BP_3 121.48 2.19 2962 91087321 XP_975587.1 825 4.2e-85 PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|642929809|ref|XP_008195985.1| PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|270009526|gb|EFA05974.1| hypothetical protein TcasGA2_TC008799 [Tribolium castaneum] 186969251 EU616728.1 55 3.57287e-17 Kryptolebias marmoratus R-ras3 mRNA, complete cds K07830 RRAS2, TC21 Ras-related protein R-Ras2 http://www.genome.jp/dbget-bin/www_bget?ko:K07830 P04388 659 3.0e-67 Ras-like protein 2 OS=Drosophila melanogaster GN=Ras64B PE=1 SV=2 PF08477//PF00071//PF00025//PF08469 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family//Nucleoside triphosphatase I C-terminal GO:0007264//GO:0006184//GO:0006351 small GTPase mediated signal transduction//obsolete GTP catabolic process//transcription, DNA-templated GO:0017111//GO:0005525//GO:0003924//GO:0005524 nucleoside-triphosphatase activity//GTP binding//GTPase activity//ATP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.32084 BP_3 316.83 2.98 5424 91092978 XP_967458.1 1021 1.4e-107 PREDICTED: type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [Tribolium castaneum]>gi|270004800|gb|EFA01248.1| hypothetical protein TcasGA2_TC002125 [Tribolium castaneum] 827558552 XM_012694950.1 58 1.4141e-18 PREDICTED: Bombyx mori TPPP family protein CG45057-like (LOC101741645), transcript variant X2, mRNA K13084 TMEM55 phosphatidylinositol-4,5-bisphosphate 4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K13084 Q4R6W2 542 2.1e-53 Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Macaca fascicularis GN=TMEM55B PE=2 SV=1 PF13903//PF02892//PF09788 PMP-22/EMP/MP20/Claudin tight junction//BED zinc finger//Transmembrane protein 55A GO:0046856 phosphatidylinositol dephosphorylation GO:0034597//GO:0003677 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//DNA binding GO:0016021 integral component of membrane KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger Cluster-8309.32086 BP_3 19.62 4.39 507 270007709 EFA04157.1 494 1.7e-47 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 365 6.4e-34 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF02456//PF13304//PF01926//PF00005//PF00735//PF03193//PF00931 Adenovirus IVa2 protein//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Septin//Protein of unknown function, DUF258//NB-ARC domain GO:0019083 viral transcription GO:0016887//GO:0005525//GO:0005524//GO:0003924//GO:0043531 ATPase activity//GTP binding//ATP binding//GTPase activity//ADP binding -- -- -- -- Cluster-8309.32087 BP_3 108.21 0.82 6676 642924128 XP_008194017.1 4857 0.0e+00 PREDICTED: neural-cadherin isoform X2 [Tribolium castaneum] 826495863 XM_012685575.1 613 0 PREDICTED: Monomorium pharaonis neural-cadherin (LOC105839332), transcript variant X5, mRNA -- -- -- -- O15943 4102 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF13413//PF03222//PF00028//PF00868 Helix-turn-helix domain//Tryptophan/tyrosine permease family//Cadherin domain//Transglutaminase family GO:0003333//GO:0007156//GO:0018149 amino acid transmembrane transport//homophilic cell adhesion via plasma membrane adhesion molecules//peptide cross-linking GO:0003677//GO:0005509 DNA binding//calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.32089 BP_3 21.29 17.36 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3209 BP_3 3.00 0.60 532 270015525 EFA11973.1 140 2.0e-06 hypothetical protein TcasGA2_TC004054 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32090 BP_3 31.71 48.13 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32091 BP_3 160.95 0.82 9809 270017072 EFA13518.1 1224 7.5e-131 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1016 4.0e-108 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF00098//PF09207 Integrase core domain//Zinc knuckle//Yeast killer toxin GO:0015074//GO:0008219//GO:0009405 DNA integration//cell death//pathogenesis GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.32093 BP_3 47.10 1.62 1690 91086227 XP_972385.1 1037 6.2e-110 PREDICTED: putative GPI-anchor transamidase [Tribolium castaneum] 820835140 XM_012484551.1 235 1.7548e-117 PREDICTED: Apis florea putative GPI-anchor transamidase (LOC105735008), mRNA K05290 PIGK phosphatidylinositol glycan, class K http://www.genome.jp/dbget-bin/www_bget?ko:K05290 Q8T4E1 909 1.8e-96 Putative GPI-anchor transamidase OS=Drosophila melanogaster GN=CG4406 PE=2 SV=1 PF01650 Peptidase C13 family GO:0006508 proteolysis GO:0008233 peptidase activity -- -- KOG1349 Gpi-anchor transamidase Cluster-8309.32097 BP_3 107.54 1.85 3087 642934677 XP_008197764.1 2325 5.0e-259 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X3 [Tribolium castaneum] 556762122 XM_005976302.1 125 4.55407e-56 PREDICTED: Pantholops hodgsonii adenylate cyclase 1 (brain) (ADCY1), mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1565 2.8e-172 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.32098 BP_3 724.81 9.94 3808 642934673 XP_008197762.1 915 2.0e-95 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X1 [Tribolium castaneum] 642934684 XM_008199547.1 208 4.08398e-102 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 220 3.1e-16 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF03594 Benzoate membrane transport protein GO:0042919//GO:0006810 benzoate transport//transport GO:0042925 benzoate transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.32099 BP_3 285.49 1.96 7327 642934675 XP_008197763.1 4436 0.0e+00 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 642934684 XM_008199547.1 110 2.37139e-47 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1584 4.1e-174 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF02542//PF00211 YgbB family//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0016114 cyclic nucleotide biosynthetic process//intracellular signal transduction//terpenoid biosynthetic process GO:0016849//GO:0008685 phosphorus-oxygen lyase activity//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity -- -- -- -- Cluster-8309.32100 BP_3 4.71 0.33 977 478251739 ENN72191.1 247 1.4e-18 hypothetical protein YQE_11151, partial [Dendroctonus ponderosae]>gi|546670640|gb|ERL83324.1| hypothetical protein D910_00219 [Dendroctonus ponderosae]>gi|546672556|gb|ERL84373.1| hypothetical protein D910_01801 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32104 BP_3 565.30 14.39 2185 91076782 XP_967792.1 2163 2.2e-240 PREDICTED: sphingosine-1-phosphate lyase [Tribolium castaneum]>gi|270001960|gb|EEZ98407.1| hypothetical protein TcasGA2_TC000875 [Tribolium castaneum] -- -- -- -- -- K01634 SGPL1, DPL1 sphinganine-1-phosphate aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01634 Q9V7Y2 1803 5.0e-200 Sphingosine-1-phosphate lyase OS=Drosophila melanogaster GN=Sply PE=2 SV=1 PF01053//PF01212//PF00282//PF00155//PF05889//PF04099//PF07497 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain//Aminotransferase class I and II//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//Sybindin-like family//Rho termination factor, RNA-binding domain GO:0019752//GO:0006888//GO:0006520//GO:0009058//GO:0006353 carboxylic acid metabolic process//ER to Golgi vesicle-mediated transport//cellular amino acid metabolic process//biosynthetic process//DNA-templated transcription, termination GO:0030170//GO:0003723//GO:0016831//GO:0016740//GO:0016829 pyridoxal phosphate binding//RNA binding//carboxy-lyase activity//transferase activity//lyase activity GO:0005801 cis-Golgi network KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase Cluster-8309.32105 BP_3 879.87 120.72 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32108 BP_3 1728.05 26.93 3385 642912309 XP_008200644.1 1969 1.1e-217 PREDICTED: glycerol-3-phosphate acyltransferase 4 isoform X2 [Tribolium castaneum] 545878863 XM_005672663.1 113 2.34226e-49 PREDICTED: Sus scrofa 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (AGPAT6), transcript variant X2, mRNA K13506 GPAT3_4, AGPAT9, AGPAT6 glycerol-3-phosphate O-acyltransferase 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13506 Q8K2C8 1146 1.2e-123 Glycerol-3-phosphate acyltransferase 4 OS=Mus musculus GN=Agpat6 PE=2 SV=1 PF01553//PF00481 Acyltransferase//Protein phosphatase 2C GO:0008152 metabolic process GO:0003824//GO:0016746 catalytic activity//transferase activity, transferring acyl groups -- -- KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.3211 BP_3 9.00 0.65 957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32110 BP_3 71.09 2.31 1778 642915553 XP_008190664.1 1295 7.9e-140 PREDICTED: RNA-binding protein 25 isoform X3 [Tribolium castaneum] 564267634 XM_006272560.1 54 7.65727e-17 PREDICTED: Alligator mississippiensis RNA binding motif protein 25 (RBM25), mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 1.4e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.32111 BP_3 430.06 3.07 7036 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 4.89351e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 1.6e-26 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF13895//PF13855//PF03526//PF00560 Immunoglobulin domain//Leucine rich repeat//Colicin E1 (microcin) immunity protein//Leucine Rich Repeat GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643//GO:0005515 toxic substance binding//protein binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.32112 BP_3 143.35 2.02 3715 642915551 XP_008190663.1 1295 1.7e-139 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 71 5.72957e-26 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 2.9e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.32115 BP_3 224.00 4.68 2601 642923875 XP_966553.2 1626 4.8e-178 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC654991 [Tribolium castaneum] -- -- -- -- -- K06129 LYPLA3 lysophospholipase III http://www.genome.jp/dbget-bin/www_bget?ko:K06129 Q8NCC3 1002 4.5e-107 Group XV phospholipase A2 OS=Homo sapiens GN=PLA2G15 PE=1 SV=2 PF01674//PF02450//PF07819 Lipase (class 2)//Lecithin:cholesterol acyltransferase//PGAP1-like protein GO:0042967//GO:0006886//GO:0006629//GO:0006505 acyl-carrier-protein biosynthetic process//intracellular protein transport//lipid metabolic process//GPI anchor metabolic process GO:0008374//GO:0016787//GO:0016788 O-acyltransferase activity//hydrolase activity//hydrolase activity, acting on ester bonds -- -- KOG2369 Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase Cluster-8309.32117 BP_3 18.15 0.56 1848 546685827 ERL95270.1 1821 8.4e-201 hypothetical protein D910_12536 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NRA2 656 4.2e-67 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32120 BP_3 1066.34 22.89 2537 91076230 XP_972985.1 678 4.0e-68 PREDICTED: synaptoporin [Tribolium castaneum]>gi|642911829|ref|XP_008200762.1| PREDICTED: synaptoporin [Tribolium castaneum]>gi|270014547|gb|EFA10995.1| hypothetical protein TcasGA2_TC004580 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5YJC1 397 6.3e-37 Synaptophysin OS=Spermophilus citellus GN=SYP PE=2 SV=1 PF01284//PF00654 Membrane-associating domain//Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane -- -- Cluster-8309.32121 BP_3 45.95 0.38 6096 642913346 XP_967720.2 5481 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270002774|gb|EEZ99221.1| hypothetical protein TcasGA2_TC000625 [Tribolium castaneum] 759033122 XM_011346822.1 60 1.22951e-19 PREDICTED: Cerapachys biroi chaoptin-like (LOC105283719), transcript variant X2, mRNA -- -- -- -- P12024 466 1.5e-44 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF00041//PF13855 Leucine Rich Repeat//Fibronectin type III domain//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.32122 BP_3 972.46 27.75 1981 91085293 XP_968143.1 1388 1.5e-150 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 P52788 700 3.6e-72 Spermine synthase OS=Homo sapiens GN=SMS PE=1 SV=2 PF00891//PF03602//PF05175//PF02390//PF08241 O-methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain//Putative methyltransferase//Methyltransferase domain GO:0006400//GO:0019482//GO:0006597//GO:0008033//GO:0009451//GO:0006560//GO:0031167//GO:0006525//GO:0008152 tRNA modification//beta-alanine metabolic process//spermine biosynthetic process//tRNA processing//RNA modification//proline metabolic process//rRNA methylation//arginine metabolic process//metabolic process GO:0008168//GO:0008176//GO:0016768//GO:0008171 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//spermine synthase activity//O-methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.32123 BP_3 229.55 6.32 2042 91085293 XP_968143.1 1224 1.6e-131 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 P52788 627 1.1e-63 Spermine synthase OS=Homo sapiens GN=SMS PE=1 SV=2 PF08241//PF01728//PF02390//PF05175//PF03602//PF00891 Methyltransferase domain//FtsJ-like methyltransferase//Putative methyltransferase//Methyltransferase small domain//Conserved hypothetical protein 95//O-methyltransferase GO:0006525//GO:0008152//GO:0031167//GO:0006560//GO:0009451//GO:0006597//GO:0008033//GO:0019482//GO:0032259//GO:0006400 arginine metabolic process//metabolic process//rRNA methylation//proline metabolic process//RNA modification//spermine biosynthetic process//tRNA processing//beta-alanine metabolic process//methylation//tRNA modification GO:0008171//GO:0016768//GO:0008176//GO:0008168 O-methyltransferase activity//spermine synthase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.32124 BP_3 29.30 0.53 2956 91085293 XP_968143.1 1025 2.7e-108 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 P52788 607 3.3e-61 Spermine synthase OS=Homo sapiens GN=SMS PE=1 SV=2 PF00891//PF05175//PF01728//PF02390//PF08241//PF03602 O-methyltransferase//Methyltransferase small domain//FtsJ-like methyltransferase//Putative methyltransferase//Methyltransferase domain//Conserved hypothetical protein 95 GO:0031167//GO:0006560//GO:0008152//GO:0006525//GO:0019482//GO:0032259//GO:0006400//GO:0006597//GO:0008033//GO:0009451 rRNA methylation//proline metabolic process//metabolic process//arginine metabolic process//beta-alanine metabolic process//methylation//tRNA modification//spermine biosynthetic process//tRNA processing//RNA modification GO:0008171//GO:0008168//GO:0016768//GO:0008176 O-methyltransferase activity//methyltransferase activity//spermine synthase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.32127 BP_3 50.00 1.74 1674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF01777//PF13912//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Ribosomal L27e protein family//C2H2-type zinc finger//BED zinc finger GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0046872//GO:0003735//GO:0003677 metal ion binding//structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.32129 BP_3 118.79 2.15 2951 861626561 KMQ88832.1 811 1.7e-83 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225 DDE superfamily endonuclease//helix-turn-helix, Psq domain -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.32131 BP_3 55.88 0.74 3929 270010165 EFA06613.1 761 1.5e-77 hypothetical protein TcasGA2_TC009528 [Tribolium castaneum] -- -- -- -- -- K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 -- -- -- -- PF03427 Carbohydrate binding domain (family 19) GO:0006032 chitin catabolic process GO:0008061 chitin binding -- -- -- -- Cluster-8309.32133 BP_3 42.00 4.62 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32134 BP_3 275.30 4.56 3202 642921094 XP_008192689.1 2519 1.7e-281 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q6GP15 789 2.8e-82 Mediator of RNA polymerase II transcription subunit 25 OS=Xenopus laevis GN=med25 PE=2 SV=1 PF09398//PF00643 FOP N terminal dimerisation domain//B-box zinc finger GO:0034453 microtubule anchoring GO:0008270 zinc ion binding GO:0005815//GO:0005622 microtubule organizing center//intracellular -- -- Cluster-8309.32135 BP_3 36.04 0.58 3262 642921092 XP_008192688.1 2512 1.1e-280 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q6GP15 789 2.8e-82 Mediator of RNA polymerase II transcription subunit 25 OS=Xenopus laevis GN=med25 PE=2 SV=1 PF09398//PF00643 FOP N terminal dimerisation domain//B-box zinc finger GO:0034453 microtubule anchoring GO:0008270 zinc ion binding GO:0005622//GO:0005815 intracellular//microtubule organizing center -- -- Cluster-8309.32136 BP_3 3073.05 20.15 7642 642916293 XP_008190963.1 10096 0.0e+00 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X1 [Tribolium castaneum]>gi|270004176|gb|EFA00624.1| hypothetical protein TcasGA2_TC003500 [Tribolium castaneum] 642916292 XM_008192741.1 1474 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 1 (LOC663739), transcript variant X1, mRNA K12604 CNOT1, NOT1 CCR4-NOT transcription complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12604 Q6ZQ08 6499 0.0e+00 CCR4-NOT transcription complex subunit 1 OS=Mus musculus GN=Cnot1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1831 Negative regulator of transcription Cluster-8309.32140 BP_3 24.00 94.22 271 291170322 ADD82417.1 305 7.5e-26 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 135 9.81689e-63 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32141 BP_3 9057.02 1317.63 623 91078856 XP_972007.1 532 8.3e-52 PREDICTED: 60S ribosomal protein L36 [Tribolium castaneum]>gi|270003715|gb|EFA00163.1| hypothetical protein TcasGA2_TC002985 [Tribolium castaneum] -- -- -- -- -- K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 P49630 426 6.6e-41 60S ribosomal protein L36 OS=Drosophila melanogaster GN=RpL36 PE=1 SV=1 PF01158 Ribosomal protein L36e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3452 60S ribosomal protein L36 Cluster-8309.32143 BP_3 105.20 1.06 5071 270011060 EFA07508.1 3831 0.0e+00 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20742 1230 3.2e-133 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 PF07677//PF01835//PF07678//PF01483//PF00207 A-macroglobulin receptor//MG2 domain//A-macroglobulin complement component//Proprotein convertase P-domain//Alpha-2-macroglobulin family GO:0006508 proteolysis GO:0004252//GO:0004866 serine-type endopeptidase activity//endopeptidase inhibitor activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.32144 BP_3 4.05 0.42 755 646703952 KDR12362.1 358 1.5e-31 Superoxide dismutase [Cu-Zn] [Zootermopsis nevadensis] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P41973 326 3.2e-29 Superoxide dismutase [Cu-Zn] OS=Drosophila willistoni GN=Sod PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.32146 BP_3 56.00 0.97 3076 91078182 XP_967647.1 2377 4.7e-265 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NCI6 1013 2.8e-108 Beta-galactosidase-1-like protein 3 OS=Homo sapiens GN=GLB1L3 PE=2 SV=3 PF02449 Beta-galactosidase GO:0006687//GO:0005975//GO:0046486//GO:0006027//GO:0006012 glycosphingolipid metabolic process//carbohydrate metabolic process//glycerolipid metabolic process//glycosaminoglycan catabolic process//galactose metabolic process GO:0043169//GO:0004565 cation binding//beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.32149 BP_3 299.44 3.41 4523 642911078 XP_008200566.1 2414 3.5e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 4.1e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF00076//PF11648//PF01585//PF01080//PF07808//PF00641//PF13442 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C-terminal domain of RIG-I//G-patch domain//Presenilin//RED-like protein N-terminal region//Zn-finger in Ran binding protein and others//Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0004190//GO:0003676//GO:0009055//GO:0008270//GO:0000166//GO:0016817//GO:0020037 aspartic-type endopeptidase activity//nucleic acid binding//electron carrier activity//zinc ion binding//nucleotide binding//hydrolase activity, acting on acid anhydrides//heme binding GO:0005634//GO:0016021//GO:0005622 nucleus//integral component of membrane//intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.32150 BP_3 195.91 3.72 2827 642914797 XP_008190357.1 1046 9.4e-111 PREDICTED: poly(rC)-binding protein 3 isoform X1 [Tribolium castaneum]>gi|642914799|ref|XP_008190358.1| PREDICTED: poly(rC)-binding protein 3 isoform X1 [Tribolium castaneum]>gi|642914801|ref|XP_008190359.1| PREDICTED: poly(rC)-binding protein 3 isoform X1 [Tribolium castaneum] 642914800 XM_008192137.1 406 0 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X3, mRNA K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 P57721 738 2.0e-76 Poly(rC)-binding protein 3 OS=Homo sapiens GN=PCBP3 PE=2 SV=2 PF07650//PF06326//PF00013//PF13184//PF13014 KH domain//Vesiculovirus matrix protein//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723//GO:0005198 RNA binding//structural molecule activity GO:0019031 viral envelope KOG2190 PolyC-binding proteins alphaCP-1 and related KH domain proteins Cluster-8309.32152 BP_3 17.00 8.35 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32153 BP_3 606.69 23.31 1546 189239344 XP_973859.2 1727 5.6e-190 PREDICTED: 28S ribosomal protein S5, mitochondrial [Tribolium castaneum]>gi|270010452|gb|EFA06900.1| hypothetical protein TcasGA2_TC009847 [Tribolium castaneum] -- -- -- -- -- K02988 RP-S5, MRPS5, rpsE small subunit ribosomal protein S5 http://www.genome.jp/dbget-bin/www_bget?ko:K02988 Q2KID9 705 7.4e-73 28S ribosomal protein S5, mitochondrial OS=Bos taurus GN=MRPS5 PE=1 SV=1 PF03719//PF00333 Ribosomal protein S5, C-terminal domain//Ribosomal protein S5, N-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840 ribosome KOG2646 Ribosomal protein S5 Cluster-8309.32154 BP_3 505.00 11.32 2442 642910741 XP_008193389.1 2229 5.4e-248 PREDICTED: UPF0518 protein AGAP011705 [Tribolium castaneum]>gi|270015022|gb|EFA11470.1| hypothetical protein TcasGA2_TC014180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PZ36 1341 2.1e-146 UPF0518 protein AGAP011705 OS=Anopheles gambiae GN=AGAP011705 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG3695 Uncharacterized conserved protein Cluster-8309.32157 BP_3 153.38 1.78 4449 546683810 ERL93563.1 2164 3.4e-240 hypothetical protein D910_10852 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1388 1.3e-151 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF01637//PF02367//PF00005//PF03193//PF00931//PF00664//PF13304//PF01926//PF01695//PF00437//PF00004 Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258//NB-ARC domain//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//IstB-like ATP binding protein//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0002949//GO:0055085//GO:0006810 tRNA threonylcarbamoyladenosine modification//transmembrane transport//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924//GO:0043531 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//ADP binding GO:0016021 integral component of membrane -- -- Cluster-8309.32158 BP_3 33.00 1.38 1447 556728350 XP_005959908.1 524 1.6e-50 PREDICTED: zinc finger protein 836-like [Pantholops hodgsonii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 489 7.7e-48 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF13465//PF00096//PF13912//PF02892//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.32160 BP_3 233.76 9.14 1524 642928886 XP_008195603.1 400 4.1e-36 PREDICTED: junctional adhesion molecule B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32161 BP_3 15.20 0.81 1191 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32162 BP_3 8.00 0.58 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32163 BP_3 804.38 28.36 1659 91091550 XP_971130.1 810 1.3e-83 PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Tribolium castaneum]>gi|270000919|gb|EEZ97366.1| hypothetical protein TcasGA2_TC011188 [Tribolium castaneum]>gi|332373990|gb|AEE62136.1| unknown [Dendroctonus ponderosae]>gi|546685461|gb|ERL94965.1| hypothetical protein D910_12237 [Dendroctonus ponderosae] 657798762 XM_008328253.1 115 8.78313e-51 PREDICTED: Cynoglossus semilaevis ubiquitin-conjugating enzyme E2 A (LOC103391826), mRNA K10573 UBE2A, UBC2, RAD6A ubiquitin-conjugating enzyme E2 A http://www.genome.jp/dbget-bin/www_bget?ko:K10573 P25153 791 8.4e-83 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=UbcD6 PE=2 SV=2 PF05773//PF05743 RWD domain//UEV domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0005524//GO:0016881//GO:0005515 ATP binding//acid-amino acid ligase activity//protein binding -- -- KOG0419 Ubiquitin-protein ligase Cluster-8309.32164 BP_3 28.38 1.52 1192 91090398 XP_970402.1 897 7.5e-94 PREDICTED: mediator of RNA polymerase II transcription subunit 19 [Tribolium castaneum]>gi|270013384|gb|EFA09832.1| hypothetical protein TcasGA2_TC011979 [Tribolium castaneum] 665785746 XM_008550626.1 219 9.61867e-109 PREDICTED: Microplitis demolitor mediator of RNA polymerase II transcription subunit 19 (LOC103572159), mRNA K15137 MED19 mediator of RNA polymerase II transcription subunit 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15137 Q174D3 697 4.8e-72 Mediator of RNA polymerase II transcription subunit 19 OS=Aedes aegypti GN=MED19 PE=3 SV=1 PF02932//PF06459//PF10278 Neurotransmitter-gated ion-channel transmembrane region//Ryanodine Receptor TM 4-6//Mediator of RNA pol II transcription subunit 19 GO:0006357//GO:0006874//GO:0006811//GO:0006816 regulation of transcription from RNA polymerase II promoter//cellular calcium ion homeostasis//ion transport//calcium ion transport GO:0001104//GO:0005219 RNA polymerase II transcription cofactor activity//ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016020//GO:0016592//GO:0016021 intracellular//membrane//mediator complex//integral component of membrane -- -- Cluster-8309.32166 BP_3 2228.54 169.35 926 91079212 XP_966680.1 897 5.8e-94 PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|642916704|ref|XP_008192258.1| PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|270004989|gb|EFA01437.1| hypothetical protein TcasGA2_TC030667 [Tribolium castaneum] 665815702 XM_008558299.1 225 3.4269e-112 PREDICTED: Microplitis demolitor myosin regulatory light chain sqh (LOC103577593), mRNA K12755 MYL9 myosin regulatory light chain 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12755 P40423 847 1.5e-89 Myosin regulatory light chain sqh OS=Drosophila melanogaster GN=sqh PE=1 SV=1 PF13499//PF13833//PF10591//PF13405//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.32167 BP_3 23.00 15.94 357 91094065 XP_969875.1 240 3.4e-18 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270016181|gb|EFA12629.1| cytochrome P450 6BR1 [Tribolium castaneum] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964R1 200 6.1e-15 Cytochrome P450 6j1 OS=Blattella germanica GN=CYP6J1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506//GO:0016491//GO:0046872 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.32168 BP_3 268.00 10.36 1539 73921480 AAZ94270.1 1112 1.1e-118 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 698 4.7e-72 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005488//GO:0016705//GO:0016491//GO:0005506//GO:0020037 binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//iron ion binding//heme binding -- -- -- -- Cluster-8309.32169 BP_3 240.00 13.72 1135 -- -- -- -- -- 642934086 XM_008198387.1 57 1.03994e-18 PREDICTED: Tribolium castaneum phosphatase and actin regulator 1 (LOC656132), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32172 BP_3 2134.72 25.37 4348 91083141 XP_971340.1 615 1.4e-60 PREDICTED: akirin [Tribolium castaneum]>gi|270007685|gb|EFA04133.1| hypothetical protein TcasGA2_TC014377 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS59 340 4.4e-30 Akirin OS=Drosophila melanogaster GN=akirin PE=1 SV=1 PF00056 lactate/malate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG4330 Uncharacterized conserved protein Cluster-8309.32175 BP_3 286.25 12.81 1369 642939095 XP_008200219.1 1259 9.1e-136 PREDICTED: AH receptor-interacting protein [Tribolium castaneum]>gi|270016257|gb|EFA12703.1| hypothetical protein TcasGA2_TC002337 [Tribolium castaneum] -- -- -- -- -- K17767 AIP, XAP2 AH receptor-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17767 O00170 685 1.4e-70 AH receptor-interacting protein OS=Homo sapiens GN=AIP PE=1 SV=2 PF13414//PF00254//PF08631//PF00515//PF13181 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0051321//GO:0006457 meiotic cell cycle//protein folding GO:0005515 protein binding -- -- KOG0545 Aryl-hydrocarbon receptor-interacting protein Cluster-8309.32176 BP_3 9.47 0.40 1438 642939095 XP_008200219.1 1172 1.2e-125 PREDICTED: AH receptor-interacting protein [Tribolium castaneum]>gi|270016257|gb|EFA12703.1| hypothetical protein TcasGA2_TC002337 [Tribolium castaneum] -- -- -- -- -- K17767 AIP, XAP2 AH receptor-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17767 O00170 646 4.7e-66 AH receptor-interacting protein OS=Homo sapiens GN=AIP PE=1 SV=2 PF13181//PF00515//PF08631//PF00254//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Meiosis protein SPO22/ZIP4 like//FKBP-type peptidyl-prolyl cis-trans isomerase//TPR repeat GO:0051321//GO:0006457 meiotic cell cycle//protein folding GO:0005515 protein binding -- -- KOG0545 Aryl-hydrocarbon receptor-interacting protein Cluster-8309.32177 BP_3 44.30 1.18 2103 642915809 XP_008200087.1 1148 1.0e-122 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 475 4.7e-46 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.32178 BP_3 432.92 12.43 1971 642937291 XP_008198773.1 2091 4.4e-232 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X2 [Tribolium castaneum]>gi|270000838|gb|EEZ97285.1| hypothetical protein TcasGA2_TC011089 [Tribolium castaneum] 195481875 XM_002101781.1 176 1.28901e-84 Drosophila yakuba GE15405 (Dyak\GE15405), partial mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 1700 3.9e-188 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.32179 BP_3 552.00 23.54 1422 478250943 ENN71427.1 497 2.2e-47 hypothetical protein YQE_11846, partial [Dendroctonus ponderosae]>gi|546682689|gb|ERL92601.1| hypothetical protein D910_09914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVA0 347 2.2e-31 Cold shock domain-containing protein CG9705 OS=Drosophila melanogaster GN=CG9705 PE=1 SV=1 PF00313 'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.32180 BP_3 132.00 1.82 3795 642939400 XP_008193248.1 252 1.5e-18 PREDICTED: uncharacterized protein LOC103312106 [Tribolium castaneum]>gi|270016475|gb|EFA12921.1| hypothetical protein TcasGA2_TC006991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32183 BP_3 1805.04 56.05 1844 478258843 ENN78848.1 421 1.8e-38 hypothetical protein YQE_04696, partial [Dendroctonus ponderosae]>gi|546684143|gb|ERL93848.1| hypothetical protein D910_11134 [Dendroctonus ponderosae] -- -- -- -- -- K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P38410 396 5.9e-37 Guanine nucleotide-binding protein G(q) subunit alpha OS=Xenopus laevis GN=gnaq PE=2 SV=2 PF00503 G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0031683//GO:0019001//GO:0004871//GO:0003924 G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32184 BP_3 23.81 0.56 2324 815825480 XP_012234117.1 752 9.5e-77 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X5 [Linepithema humile] 768434415 XM_011560315.1 190 2.51443e-92 PREDICTED: Plutella xylostella guanine nucleotide-binding protein G(q) subunit alpha (LOC105389225), transcript variant X4, mRNA K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P23625 678 1.5e-69 G protein alpha q subunit OS=Drosophila melanogaster GN=Galphaq PE=2 SV=2 PF00503//PF00025 G-protein alpha subunit//ADP-ribosylation factor family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0031683//GO:0019001//GO:0004871//GO:0003924 GTP binding//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32185 BP_3 2250.19 96.47 1416 642913315 XP_008195239.1 1358 3.1e-147 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [Tribolium castaneum] 462426418 APGK01016400.1 327 1.05465e-168 Dendroctonus ponderosae Seq01016410, whole genome shotgun sequence K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P23625 1246 1.2e-135 G protein alpha q subunit OS=Drosophila melanogaster GN=Galphaq PE=2 SV=2 PF01926//PF08477//PF00025//PF04670//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0031683//GO:0003924 GTP binding//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32186 BP_3 6.01 0.50 869 815825474 XP_012234113.1 291 1.0e-23 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [Linepithema humile] -- -- -- -- -- K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P50148 278 1.3e-23 Guanine nucleotide-binding protein G(q) subunit alpha OS=Homo sapiens GN=GNAQ PE=1 SV=4 PF00503 G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0019001//GO:0004871//GO:0031683//GO:0003924 guanyl nucleotide binding//signal transducer activity//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32187 BP_3 150.94 1.05 7211 478256710 ENN76892.1 1622 3.9e-177 hypothetical protein YQE_06733, partial [Dendroctonus ponderosae]>gi|546685091|gb|ERL94618.1| hypothetical protein D910_11895 [Dendroctonus ponderosae] 749732005 XM_011139608.1 229 1.64551e-113 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1333 5.2e-145 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF13414//PF06293//PF02434//PF00069//PF07714//PF01762 TPR repeat//Lipopolysaccharide kinase (Kdo/WaaP) family//Fringe-like//Protein kinase domain//Protein tyrosine kinase//Galactosyltransferase GO:0006468//GO:0006486 protein phosphorylation//protein glycosylation GO:0005524//GO:0016757//GO:0005515//GO:0016773//GO:0008378//GO:0004672 ATP binding//transferase activity, transferring glycosyl groups//protein binding//phosphotransferase activity, alcohol group as acceptor//galactosyltransferase activity//protein kinase activity GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.32188 BP_3 29.22 1.00 1697 831573204 XP_012735619.1 786 7.9e-81 PREDICTED: glycogenin-1 isoform X2 [Fundulus heteroclitus] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 Q9R062 740 7.1e-77 Glycogenin-1 OS=Mus musculus GN=Gyg1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.32189 BP_3 225.79 3.01 3903 642928336 XP_008195540.1 2691 2.3e-301 PREDICTED: slit homolog 1 protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 294 8.5e-25 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32193 BP_3 6086.16 129.33 2560 642911289 XP_008199357.1 1942 1.1e-214 PREDICTED: uncharacterized protein LOC657053 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10401//PF03166 Interferon-regulatory factor 3//MH2 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex -- -- Cluster-8309.32194 BP_3 362.38 9.09 2213 642911289 XP_008199357.1 1942 9.3e-215 PREDICTED: uncharacterized protein LOC657053 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10401//PF03166 Interferon-regulatory factor 3//MH2 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular -- -- Cluster-8309.32195 BP_3 573.13 16.25 1992 642916772 XP_008192547.1 853 1.6e-88 PREDICTED: peptidoglycan-recognition protein LE-like [Tribolium castaneum]>gi|270004832|gb|EFA01280.1| hypothetical protein TcasGA2_TC002790 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9VXN9 410 1.5e-38 Peptidoglycan-recognition protein LE OS=Drosophila melanogaster GN=PGRP-LE PE=1 SV=1 PF05093//PF01510 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//N-acetylmuramoyl-L-alanine amidase GO:0016226//GO:0009252//GO:0006807//GO:0009253 iron-sulfur cluster assembly//peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0051536//GO:0008745 iron-sulfur cluster binding//N-acetylmuramoyl-L-alanine amidase activity GO:0005737 cytoplasm -- -- Cluster-8309.32196 BP_3 53.13 1.50 2003 642914834 XP_008194983.1 1329 1.0e-143 PREDICTED: inhibitor of growth protein 3 isoform X1 [Tribolium castaneum] 795091176 XM_012024084.1 91 2.33676e-37 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q9NXR8 715 6.6e-74 Inhibitor of growth protein 3 OS=Homo sapiens GN=ING3 PE=1 SV=2 PF00160//PF10280//PF01576//PF00628//PF12090 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Mediator complex protein//Myosin tail//PHD-finger//Spt20 family GO:0000413//GO:0006357//GO:0006457 protein peptidyl-prolyl isomerization//regulation of transcription from RNA polymerase II promoter//protein folding GO:0003755//GO:0003712//GO:0003774//GO:0005515//GO:0001104 peptidyl-prolyl cis-trans isomerase activity//transcription cofactor activity//motor activity//protein binding//RNA polymerase II transcription cofactor activity GO:0005667//GO:0000124//GO:0016592//GO:0016459 transcription factor complex//SAGA complex//mediator complex//myosin complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.32197 BP_3 256.56 10.62 1456 642914834 XP_008194983.1 729 2.8e-74 PREDICTED: inhibitor of growth protein 3 isoform X1 [Tribolium castaneum] 795091176 XM_012024084.1 91 1.68727e-37 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q8VEK6 331 1.6e-29 Inhibitor of growth protein 3 OS=Mus musculus GN=Ing3 PE=1 SV=2 PF00628//PF12090 PHD-finger//Spt20 family -- -- GO:0005515//GO:0003712 protein binding//transcription cofactor activity GO:0005667//GO:0000124 transcription factor complex//SAGA complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.32198 BP_3 8.13 0.32 1524 642916772 XP_008192547.1 686 2.8e-69 PREDICTED: peptidoglycan-recognition protein LE-like [Tribolium castaneum]>gi|270004832|gb|EFA01280.1| hypothetical protein TcasGA2_TC002790 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9VXN9 410 1.2e-38 Peptidoglycan-recognition protein LE OS=Drosophila melanogaster GN=PGRP-LE PE=1 SV=1 PF05093 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0016226 iron-sulfur cluster assembly GO:0051536 iron-sulfur cluster binding GO:0005737 cytoplasm -- -- Cluster-8309.3220 BP_3 15.97 0.80 1250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.32200 BP_3 194.13 2.92 3492 642916254 XP_008190948.1 1579 1.8e-172 PREDICTED: intersectin-2-like isoform X2 [Tribolium castaneum] 746842857 XM_011053352.1 94 8.81731e-39 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- O42287 496 2.9e-48 Intersectin-1 OS=Xenopus laevis GN=itsn1 PE=1 SV=1 PF12763//PF13499//PF14604//PF00018//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Variant SH3 domain//SH3 domain//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.32203 BP_3 726.78 12.25 3151 642939797 XP_970220.2 1795 1.5e-197 PREDICTED: uncharacterized protein LOC658765 [Tribolium castaneum] 642939796 XM_965127.2 668 0 PREDICTED: Tribolium castaneum uncharacterized LOC658765 (LOC658765), mRNA K03649 MUG, TDG TDG/mug DNA glycosylase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03649 Q13569 615 4.1e-62 G/T mismatch-specific thymine DNA glycosylase OS=Homo sapiens GN=TDG PE=1 SV=2 PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- KOG4120 G/T mismatch-specific thymine DNA glycosylase Cluster-8309.32204 BP_3 366.30 5.77 3351 823397613 XP_012412169.1 387 2.9e-34 PREDICTED: macrophage mannose receptor 1 [Trichechus manatus latirostris] -- -- -- -- -- -- -- -- -- P22897 349 3.0e-31 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03791//PF07840 KNOX2 domain//FadR C-terminal domain GO:0019217 regulation of fatty acid metabolic process GO:0003677//GO:0000062 DNA binding//fatty-acyl-CoA binding GO:0005634 nucleus KOG4297 C-type lectin Cluster-8309.32206 BP_3 19.00 2.27 696 642922790 XP_008193326.1 171 6.7e-10 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32208 BP_3 89.65 1.42 3332 270009742 EFA06190.1 1089 1.1e-115 hypothetical protein TcasGA2_TC009039 [Tribolium castaneum] -- -- -- -- -- K17043 DDX43 ATP-dependent RNA helicase DDX43 http://www.genome.jp/dbget-bin/www_bget?ko:K17043 Q9NXZ2 762 3.9e-79 Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens GN=DDX43 PE=2 SV=2 PF00270//PF07650//PF00013//PF02730//PF04851//PF13014 DEAD/DEAH box helicase//KH domain//KH domain//Aldehyde ferredoxin oxidoreductase, N-terminal domain//Type III restriction enzyme, res subunit//KH domain GO:0055114 oxidation-reduction process GO:0005524//GO:0003723//GO:0016625//GO:0003677//GO:0016787//GO:0016491//GO:0051536//GO:0003676 ATP binding//RNA binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//DNA binding//hydrolase activity//oxidoreductase activity//iron-sulfur cluster binding//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.32209 BP_3 55.43 0.84 3486 189235651 XP_969031.2 2273 6.1e-253 PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917505|ref|XP_008191230.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917507|ref|XP_008191231.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917509|ref|XP_008191232.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum] 389611492 AK402738.1 219 2.86724e-108 Papilio xuthus mRNA for dusky, partial cds, sequence id: Px-0224, expressed in epidermis -- -- -- -- O59832 460 4.3e-44 Uncharacterized dipeptidase C965.12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC965.12 PE=3 SV=1 PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- KOG4127 Renal dipeptidase Cluster-8309.3221 BP_3 6.00 0.32 1206 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32210 BP_3 2307.38 15.08 7666 533200262 XP_005412710.1 597 3.0e-58 PREDICTED: zinc finger protein 347-like isoform X2 [Chinchilla lanigera] 642926231 XM_008196617.1 95 5.40999e-39 PREDICTED: Tribolium castaneum transcriptional activator protein Pur-alpha (LOC662482), transcript variant X2, mRNA -- -- -- -- A6NK75 565 6.3e-56 Zinc finger protein 98 OS=Homo sapiens GN=ZNF98 PE=2 SV=4 PF13912//PF03248//PF16622//PF00096//PF13465 C2H2-type zinc finger//Rer1 family//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.32213 BP_3 180.20 1.32 6864 349584988 BAL03254.1 1877 1.0e-206 93 kDa serpin [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8TMP0 426 7.3e-40 Uncharacterized serpin-like protein MA_2613/MA_2612 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=MA_2613/MA_2612 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32214 BP_3 79.56 2.36 1916 270013779 EFA10227.1 582 4.1e-57 hypothetical protein TcasGA2_TC012423 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20241 222 9.3e-17 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.32216 BP_3 20.79 1.07 1224 642918767 XP_008191575.1 522 2.4e-50 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q71RP1 371 3.1e-34 Heparanase OS=Rattus norvegicus GN=Hpse PE=2 SV=1 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.32217 BP_3 14.00 0.85 1088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32218 BP_3 10.16 0.69 1006 157114447 XP_001652275.1 848 3.0e-88 AAEL006866-PA [Aedes aegypti]>gi|108877265|gb|EAT41490.1| AAEL006866-PA [Aedes aegypti] 229608898 NM_001159998.1 46 1.19606e-12 Nasonia vitripennis muscle LIM protein (LOC100122977), transcript variant 2, mRNA K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 771 1.1e-80 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412//PF09297 LIM domain//NADH pyrophosphatase zinc ribbon domain -- -- GO:0046872//GO:0008270//GO:0016787 metal ion binding//zinc ion binding//hydrolase activity -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.32219 BP_3 525.35 6.38 4262 91084191 XP_967340.1 2840 0.0e+00 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270008779|gb|EFA05227.1| hypothetical protein TcasGA2_TC015371 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 2117 3.8e-236 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF10399//PF07992//PF05834//PF00732 GMC oxidoreductase//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase GO:0006119//GO:0006066//GO:0006563//GO:0015992//GO:0006544//GO:0055114//GO:0006118//GO:0006566//GO:0016117 oxidative phosphorylation//alcohol metabolic process//L-serine metabolic process//proton transport//glycine metabolic process//oxidation-reduction process//obsolete electron transport//threonine metabolic process//carotenoid biosynthetic process GO:0008121//GO:0016491//GO:0016705//GO:0016614//GO:0008812//GO:0050660 ubiquinol-cytochrome-c reductase activity//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.32220 BP_3 140.76 11.46 884 642920912 XP_008192612.1 980 1.3e-103 PREDICTED: outer dense fiber protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8AVY1 287 1.2e-24 Outer dense fiber protein 3 OS=Xenopus laevis GN=odf3 PE=2 SV=1 PF05953 Allatostatin GO:0007218 neuropeptide signaling pathway GO:0005184 neuropeptide hormone activity -- -- -- -- Cluster-8309.32221 BP_3 28.36 1.26 1381 642920916 XP_008192614.1 292 1.2e-23 PREDICTED: outer dense fiber protein 3 isoform X3 [Tribolium castaneum] 462345164 APGK01034774.1 40 3.58409e-09 Dendroctonus ponderosae Seq01034784, whole genome shotgun sequence -- -- -- -- Q5EB30 133 1.4e-06 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32222 BP_3 68.16 5.77 861 642920912 XP_008192612.1 717 4.0e-73 PREDICTED: outer dense fiber protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 274 3.9e-23 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32224 BP_3 1912.04 90.24 1313 91086893 XP_970527.1 602 1.3e-59 PREDICTED: protein CDV3 homolog isoform X2 [Tribolium castaneum]>gi|270009679|gb|EFA06127.1| hypothetical protein TcasGA2_TC008970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16053 153 6.4e-09 Protein CDV3 homolog OS=Drosophila yakuba GN=GE14456 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32225 BP_3 770.15 32.55 1432 820841547 XP_012339133.1 508 1.2e-48 PREDICTED: LOW QUALITY PROTEIN: tryptase-2-like [Apis florea] -- -- -- -- -- -- -- -- -- P00750 272 1.1e-22 Tissue-type plasminogen activator OS=Homo sapiens GN=PLAT PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32226 BP_3 11.23 0.45 1492 820841547 XP_012339133.1 481 1.6e-45 PREDICTED: LOW QUALITY PROTEIN: tryptase-2-like [Apis florea] -- -- -- -- -- -- -- -- -- P00750 249 5.3e-20 Tissue-type plasminogen activator OS=Homo sapiens GN=PLAT PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32228 BP_3 51.56 0.46 5676 270006679 EFA03127.1 574 1.0e-55 hypothetical protein TcasGA2_TC013038 [Tribolium castaneum] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM92 384 4.5e-35 Tubulin glycylase 3B OS=Drosophila melanogaster GN=TTLL3B PE=1 SV=2 PF04111//PF06156//PF03194//PF03255//PF07478//PF02601//PF03133 Autophagy protein Apg6//Protein of unknown function (DUF972)//LUC7 N_terminus//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//D-ala D-ala ligase C-terminus//Exonuclease VII, large subunit//Tubulin-tyrosine ligase family GO:0006260//GO:0006090//GO:0006464//GO:0006376//GO:0006914//GO:0006308//GO:0009252//GO:0006633//GO:0046436 DNA replication//pyruvate metabolic process//cellular protein modification process//mRNA splice site selection//autophagy//DNA catabolic process//peptidoglycan biosynthetic process//fatty acid biosynthetic process//D-alanine metabolic process GO:0003729//GO:0008716//GO:0003989//GO:0008855 mRNA binding//D-alanine-D-alanine ligase activity//acetyl-CoA carboxylase activity//exodeoxyribonuclease VII activity GO:0009318//GO:0009317//GO:0005685 exodeoxyribonuclease VII complex//acetyl-CoA carboxylase complex//U1 snRNP KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.32229 BP_3 1.00 0.32 442 828177632 AKK25139.1 192 1.6e-12 odorant binding protein 15 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.32231 BP_3 819.69 17.20 2589 332373408 AEE61845.1 1534 2.2e-167 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 563 3.6e-56 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32234 BP_3 1888.40 17.70 5435 283046718 NP_001164305.1 2081 1.7e-230 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 432 0 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q91YT0 1897 1.6e-210 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus GN=Ndufv1 PE=1 SV=1 PF10589//PF04177 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region//TAP42-like family GO:0055114//GO:0015992//GO:0006814//GO:0006744//GO:0009966//GO:0006120 oxidation-reduction process//proton transport//sodium ion transport//ubiquinone biosynthetic process//regulation of signal transduction//mitochondrial electron transport, NADH to ubiquinone GO:0051539//GO:0008137//GO:0051287//GO:0010181 4 iron, 4 sulfur cluster binding//NADH dehydrogenase (ubiquinone) activity//NAD binding//FMN binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.32235 BP_3 25.62 0.83 1785 642940077 XP_008192917.1 1067 2.2e-113 PREDICTED: UPF0489 protein C5orf22 homolog isoform X1 [Tribolium castaneum]>gi|270016013|gb|EFA12461.1| hypothetical protein TcasGA2_TC010608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PAE6 584 9.1e-59 UPF0489 protein C5orf22 homolog OS=Xenopus laevis PE=2 SV=1 PF01668 SmpB protein -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.32237 BP_3 729.43 5.39 6814 546681938 ERL91934.1 5306 0.0e+00 hypothetical protein D910_09257, partial [Dendroctonus ponderosae] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 O88572 3260 0.0e+00 Low-density lipoprotein receptor-related protein 6 OS=Mus musculus GN=Lrp6 PE=1 SV=1 PF06320//PF02244//PF12859//PF00057 GCN5-like protein 1 (GCN5L1)//Carboxypeptidase activation peptide//Anaphase-promoting complex subunit 1//Low-density lipoprotein receptor domain class A GO:0006508 proteolysis GO:0005515//GO:0004180 protein binding//carboxypeptidase activity GO:0005680//GO:0031083 anaphase-promoting complex//BLOC-1 complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.32239 BP_3 89.84 2.17 2288 546681042 ERL91207.1 2449 1.6e-273 hypothetical protein D910_08545 [Dendroctonus ponderosae] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10714 1662 1.2e-183 Angiotensin-converting enzyme OS=Drosophila melanogaster GN=Ance PE=1 SV=3 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.32240 BP_3 7503.61 236.34 1822 642912940 XP_008201316.1 860 2.2e-89 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80034 565 1.5e-56 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32241 BP_3 44.29 0.34 6492 270000843 EEZ97290.1 1515 8.9e-165 hypothetical protein TcasGA2_TC011095 [Tribolium castaneum] 642937273 XM_008200545.1 236 1.90177e-117 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X2, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 763 5.8e-79 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF00595//PF16867//PF01369 PDZ domain (Also known as DHR or GLGF)//Dimethlysulfonioproprionate lyase//Sec7 domain GO:0043087//GO:0032012 regulation of GTPase activity//regulation of ARF protein signal transduction GO:0047869//GO:0005086//GO:0005515 dimethylpropiothetin dethiomethylase activity//ARF guanyl-nucleotide exchange factor activity//protein binding -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.32243 BP_3 441.25 15.04 1706 91080051 XP_973222.1 891 5.3e-93 PREDICTED: protein lin-7 homolog C [Tribolium castaneum]>gi|270003212|gb|EEZ99659.1| hypothetical protein TcasGA2_TC002416 [Tribolium castaneum] 805812653 XM_012292327.1 199 1.82262e-97 PREDICTED: Megachile rotundata protein lin-7 homolog C (LOC100884077), transcript variant X5, mRNA -- -- -- -- Q5F425 746 1.4e-77 Protein lin-7 homolog C OS=Gallus gallus GN=LIN7C PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.32244 BP_3 73.00 2.11 1959 332374712 AEE62497.1 1511 7.8e-165 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O02437 716 4.9e-74 Protein yellow OS=Drosophila subobscura GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32245 BP_3 16.98 0.65 1545 189235643 XP_967729.2 1430 1.5e-155 PREDICTED: metallophosphoesterase 1 [Tribolium castaneum]>gi|270004406|gb|EFA00854.1| hypothetical protein TcasGA2_TC003757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZK82 748 7.6e-78 Metallophosphoesterase 1 OS=Gallus gallus GN=MPPE1 PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3662 Cell division control protein/predicted DNA repair exonuclease Cluster-8309.32246 BP_3 362.77 11.55 1805 91092240 XP_971305.1 1651 4.2e-181 PREDICTED: lysosomal Pro-X carboxypeptidase [Tribolium castaneum]>gi|270014428|gb|EFA10876.1| hypothetical protein TcasGA2_TC001698 [Tribolium castaneum] -- -- -- -- -- K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q2TA14 1163 6.7e-126 Lysosomal Pro-X carboxypeptidase OS=Bos taurus GN=PRCP PE=2 SV=1 PF05577//PF10403//PF00326 Serine carboxypeptidase S28//Rad4 beta-hairpin domain 1//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236//GO:0003677 serine-type peptidase activity//DNA binding -- -- KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.32249 BP_3 483.00 66.46 642 189240098 XP_972684.2 717 3.0e-73 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [Tribolium castaneum]>gi|270012783|gb|EFA09231.1| hypothetical protein TcasGA2_TC006357 [Tribolium castaneum] -- -- -- -- -- K03966 NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03966 Q1HPL8 531 4.6e-53 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4009 NADH-ubiquinone oxidoreductase, subunit NDUFB10/PDSW Cluster-8309.32250 BP_3 22.00 10.40 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32253 BP_3 893.45 29.07 1773 642937779 XP_008198942.1 1221 3.0e-131 PREDICTED: 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [Tribolium castaneum] 642937778 XM_008200720.1 197 2.45225e-96 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 4 (LOC658092), transcript variant X1, mRNA K03029 PSMD4, RPN10 26S proteasome regulatory subunit N10 http://www.genome.jp/dbget-bin/www_bget?ko:K03029 Q58DA0 880 4.3e-93 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus GN=PSMD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2884 26S proteasome regulatory complex, subunit RPN10/PSMD4 Cluster-8309.32254 BP_3 10.07 1.26 678 91085373 XP_971748.1 361 6.1e-32 PREDICTED: CDGSH iron-sulfur domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|270008416|gb|EFA04864.1| hypothetical protein TcasGA2_TC014918 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AR13 222 3.3e-17 CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Mus musculus GN=Cisd3 PE=1 SV=1 -- -- -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG4605 Uncharacterized conserved protein containing CDGSH-type Zn-finger Cluster-8309.32257 BP_3 832.83 4.06 10170 642927132 XP_008195151.1 2005 2.1e-221 PREDICTED: far upstream element-binding protein 1 isoform X2 [Tribolium castaneum] 755783784 XM_006939555.2 43 5.79573e-10 PREDICTED: Felis catus far upstream element (FUSE) binding protein 3 (FUBP3), transcript variant X2, mRNA K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 2.6e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF13014//PF13184//PF00013//PF08053//PF07650//PF10192 KH domain//NusA-like KH domain//KH domain//Tryptophanase operon leader peptide//KH domain//Rhodopsin-like GPCR transmembrane domain GO:0019236//GO:0031554//GO:0007186//GO:0031556 response to pheromone//regulation of DNA-templated transcription, termination//G-protein coupled receptor signaling pathway//transcriptional attenuation by ribosome GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.32258 BP_3 102.18 3.29 1787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.32259 BP_3 16.67 3.29 536 642920087 XP_008192199.1 416 2.0e-38 PREDICTED: glycogen synthase kinase-3 beta isoform X4 [Tribolium castaneum]>gi|346654995|gb|AEO44887.1| shaggy [Tribolium castaneum] 645029971 XM_008210300.1 65 1.69336e-23 PREDICTED: Nasonia vitripennis glycogen synthase kinase-3 beta (LOC100117808), transcript variant X7, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P18431 334 2.7e-30 Protein kinase shaggy OS=Drosophila melanogaster GN=sgg PE=1 SV=3 PF00069 Protein kinase domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0658 Glycogen synthase kinase-3 Cluster-8309.3226 BP_3 75.00 4.70 1061 642926497 XP_008191980.1 643 1.9e-64 PREDICTED: iron-sulfur cluster co-chaperone protein HscB, mitochondrial [Tribolium castaneum]>gi|270008449|gb|EFA04897.1| hypothetical protein TcasGA2_TC014961 [Tribolium castaneum] -- -- -- -- -- K04082 hscB, HSCB, HSC20 molecular chaperone HscB http://www.genome.jp/dbget-bin/www_bget?ko:K04082 Q8IWL3 305 1.2e-26 Iron-sulfur cluster co-chaperone protein HscB, mitochondrial OS=Homo sapiens GN=HSCB PE=1 SV=3 PF07743//PF03965 HSCB C-terminal oligomerisation domain//Penicillinase repressor GO:0051259//GO:0045892 protein oligomerization//negative regulation of transcription, DNA-templated GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG3192 Mitochondrial J-type chaperone Cluster-8309.32260 BP_3 194.08 3.39 3053 86515428 NP_001034540.1 994 1.1e-104 protein decapentaplegic precursor [Tribolium castaneum]>gi|642921157|ref|XP_008192737.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921159|ref|XP_008192738.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921161|ref|XP_008192739.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|2501171|sp|Q26974.1|DECA_TRICA RecName: Full=Protein decapentaplegic; Flags: Precursor>gi|1458196|gb|AAB38392.1| decapentaplegic protein [Tribolium castaneum]>gi|270006465|gb|EFA02913.1| decapentaplegic [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 Q26974 994 4.5e-106 Protein decapentaplegic OS=Tribolium castaneum GN=dpp PE=3 SV=1 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity -- -- -- -- Cluster-8309.32262 BP_3 368.32 30.08 882 642914766 XP_008190343.1 385 1.3e-34 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P19236 194 7.5e-14 Mastin OS=Canis familiaris PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32263 BP_3 22.41 0.37 3181 817058472 XP_012250699.1 325 4.3e-27 PREDICTED: tryptase beta-2-like [Athalia rosae] -- -- -- -- -- K01340 E3.4.21.59 tryptase http://www.genome.jp/dbget-bin/www_bget?ko:K01340 P19236 175 4.3e-11 Mastin OS=Canis familiaris PE=1 SV=2 PF00089//PF00647//PF03609 Trypsin//Elongation factor 1 gamma, conserved domain//PTS system sorbose-specific iic component GO:0006508//GO:0009401//GO:0006448//GO:0006414 proteolysis//phosphoenolpyruvate-dependent sugar phosphotransferase system//regulation of translational elongation//translational elongation GO:0004252//GO:0003746 serine-type endopeptidase activity//translation elongation factor activity GO:0005840//GO:0016021 ribosome//integral component of membrane -- -- Cluster-8309.32266 BP_3 332.56 4.46 3889 189235515 XP_970821.2 1626 7.2e-178 PREDICTED: G patch domain-containing protein 1 [Tribolium castaneum]>gi|270003037|gb|EEZ99484.1| hypothetical protein TcasGA2_TC000059 [Tribolium castaneum] -- -- -- -- -- K13123 GPATCH1 G patch domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13123 Q9VUA0 503 4.9e-49 G patch domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG8833 PE=2 SV=1 PF00462//PF07689//PF00085//PF08534//PF02966//PF01323 Glutaredoxin//KaiB domain//Thioredoxin//Redoxin//Mitosis protein DIM1//DSBA-like thioredoxin domain GO:0048511//GO:0000398//GO:0045454//GO:0006118 rhythmic process//mRNA splicing, via spliceosome//cell redox homeostasis//obsolete electron transport GO:0016491//GO:0015035//GO:0009055 oxidoreductase activity//protein disulfide oxidoreductase activity//electron carrier activity GO:0005681 spliceosomal complex KOG2138 Predicted RNA binding protein, contains G-patch domain Cluster-8309.32268 BP_3 118.37 4.89 1458 91082161 XP_970591.1 962 2.7e-101 PREDICTED: reticulocalbin-2 [Tribolium castaneum]>gi|270007433|gb|EFA03881.1| hypothetical protein TcasGA2_TC014005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X186 396 4.7e-37 Calumenin-A OS=Salmo salar GN=calua PE=2 SV=1 PF13202//PF13499//PF10591//PF00036//PF13833//PF13405 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain pair//EF-hand domain GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.32269 BP_3 334.71 13.05 1528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32270 BP_3 826.00 13.61 3217 91080073 XP_967657.1 2374 1.1e-264 PREDICTED: ER membrane protein complex subunit 1 [Tribolium castaneum]>gi|270003203|gb|EEZ99650.1| hypothetical protein TcasGA2_TC002407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N766 1029 4.1e-110 ER membrane protein complex subunit 1 OS=Homo sapiens GN=EMC1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2103 Uncharacterized conserved protein Cluster-8309.32271 BP_3 168.88 1.44 5950 642933239 XP_008197324.1 860 7.3e-89 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32279 BP_3 374.17 42.31 718 332373648 AEE61965.1 531 1.2e-51 unknown [Dendroctonus ponderosae]>gi|478253491|gb|ENN73818.1| hypothetical protein YQE_09596, partial [Dendroctonus ponderosae]>gi|546679126|gb|ERL89631.1| hypothetical protein D910_06996 [Dendroctonus ponderosae] -- -- -- -- -- K00236 SDHC, SDH3 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00236 Q99643 268 1.6e-22 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial OS=Homo sapiens GN=SDHC PE=1 SV=1 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0449 Succinate dehydrogenase, cytochrome b subunit Cluster-8309.3228 BP_3 7.10 0.38 1203 642926380 XP_008194901.1 577 9.7e-57 PREDICTED: uncharacterized protein LOC655777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03611 141 1.4e-07 Cyclic nucleotide-gated cation channel OS=Caenorhabditis elegans GN=tax-4 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.32281 BP_3 360.42 46.66 664 642930496 XP_008196428.1 735 2.5e-75 PREDICTED: CLIP-associating protein isoform X3 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q9NBD7 466 1.6e-45 CLIP-associating protein OS=Drosophila melanogaster GN=chb PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32284 BP_3 103.65 3.00 1956 546679304 ERL89791.1 641 6.0e-64 hypothetical protein D910_07152 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03188 Eukaryotic cytochrome b561 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32285 BP_3 58.97 1.14 2795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10220//PF07225 Uncharacterized conserved protein (DUF2146)//NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0006120//GO:0006744//GO:0006814//GO:0000184//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion -- -- Cluster-8309.32287 BP_3 13.37 0.51 1555 642929303 XP_008195780.1 1194 3.6e-128 PREDICTED: neural cell adhesion molecule 2-like [Tribolium castaneum] 642929302 XM_008197558.1 252 5.71513e-127 PREDICTED: Tribolium castaneum neural cell adhesion molecule 2-like (LOC662052), mRNA -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32288 BP_3 1959.19 33.57 3105 642919756 XP_008192053.1 2379 2.8e-265 PREDICTED: ATP-binding cassette sub-family G member 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 1126 2.2e-121 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF01061//PF01926//PF13304//PF00437//PF01079//PF00005//PF03193//PF01637//PF06414 ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Type II/IV secretion system protein//Hint module//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Zeta toxin GO:0006508//GO:0006810 proteolysis//transport GO:0005525//GO:0016887//GO:0016301//GO:0008233//GO:0005524//GO:0003924 GTP binding//ATPase activity//kinase activity//peptidase activity//ATP binding//GTPase activity GO:0016020 membrane -- -- Cluster-8309.32289 BP_3 54.98 0.71 4006 189236397 XP_971210.2 1202 1.1e-128 PREDICTED: ATP-binding cassette sub-family G member 1 isoform X2 [Tribolium castaneum]>gi|642919759|ref|XP_008192054.1| PREDICTED: ATP-binding cassette sub-family G member 1 isoform X2 [Tribolium castaneum]>gi|270005417|gb|EFA01865.1| hypothetical protein TcasGA2_TC007470 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 714 1.7e-73 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF01061//PF01926//PF13304//PF00437//PF01079//PF01637//PF06414//PF00005//PF03193 ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Type II/IV secretion system protein//Hint module//Archaeal ATPase//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0006200//GO:0006508 transport//obsolete ATP catabolic process//proteolysis GO:0005524//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0008233 ATP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//peptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.32293 BP_3 471.38 6.68 3692 91090748 XP_967687.1 314 9.3e-26 PREDICTED: tetraspanin-8 [Tribolium castaneum]>gi|270013954|gb|EFA10402.1| hypothetical protein TcasGA2_TC012641 [Tribolium castaneum] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q26499 193 4.1e-13 23 kDa integral membrane protein OS=Schistosoma haematobium PE=2 SV=1 PF02076//PF01757//PF04144//PF00335 Pheromone A receptor//Acyltransferase family//SCAMP family//Tetraspanin family GO:0007606//GO:0015031//GO:0019236//GO:0007186 sensory perception of chemical stimulus//protein transport//response to pheromone//G-protein coupled receptor signaling pathway GO:0016747//GO:0004932 transferase activity, transferring acyl groups other than amino-acyl groups//mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.32295 BP_3 91.00 5.86 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32297 BP_3 162.92 12.68 911 226968624 YP_002808573.1 942 3.5e-99 cytochrome b [Scylla paramamosain]>gi|225697860|gb|ACO07227.1| cytochrome b [Scylla paramamosain]>gi|403311099|gb|AFR34058.1| cytochrome b (mitochondrion) [Scylla paramamosain] 225697849 FJ827761.1 911 0 Scylla paramamosain mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 B0FWD7 792 3.5e-83 Cytochrome b OS=Aedes aegypti GN=mt:Cyt-b PE=3 SV=1 -- -- -- -- -- -- GO:0016020 membrane KOG4663 Cytochrome b Cluster-8309.32299 BP_3 57.15 5.12 830 642935430 XP_008198007.1 515 1.0e-49 PREDICTED: LOW QUALITY PROTEIN: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 388 2.3e-36 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32301 BP_3 3.45 1.04 451 307179877 EFN68034.1 151 9.1e-08 Zinc finger protein 569 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q6PGE4 140 7.0e-08 Zinc finger protein 316 OS=Mus musculus GN=Znf316 PE=2 SV=1 PF05191//PF13912//PF00130//PF07975//PF00096//PF13465 Adenylate kinase, active site lid//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281//GO:0046034//GO:0006144//GO:0035556 DNA repair//ATP metabolic process//purine nucleobase metabolic process//intracellular signal transduction GO:0008270//GO:0046872//GO:0004017 zinc ion binding//metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.32302 BP_3 151.48 4.98 1758 225543476 NP_001139385.1 1555 5.6e-170 ventral vein lacking [Tribolium castaneum]>gi|270008227|gb|EFA04675.1| ventral veins lacking [Tribolium castaneum] 225543475 NM_001145913.1 483 0 Tribolium castaneum ventral vein lacking (Vvl), mRNA K09365 POU3F, OTF POU domain transcription factor, class 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09365 P16241 1007 8.0e-108 POU domain protein CF1A OS=Drosophila melanogaster GN=vvl PE=2 SV=5 PF05920//PF00157//PF00046 Homeobox KN domain//Pou domain - N-terminal to homeobox domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.32306 BP_3 212.51 0.72 14435 642916328 XP_008190975.1 1331 4.3e-143 PREDICTED: glucose transporter type 1 isoform X2 [Tribolium castaneum] 642916327 XM_008192753.1 491 0 PREDICTED: Tribolium castaneum glucose transporter type 1 (LOC663886), transcript variant X2, mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 Q8IRI6 1268 3.6e-137 Glucose transporter type 1 OS=Drosophila melanogaster GN=Glut1 PE=2 SV=4 PF07690//PF00083//PF04440 Major Facilitator Superfamily//Sugar (and other) transporter//Dysbindin (Dystrobrevin binding protein 1) GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG0569 Permease of the major facilitator superfamily Cluster-8309.32307 BP_3 1188.22 7.09 8369 270012359 EFA08807.1 1914 6.2e-211 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.2e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF00198//PF13639//PF04564//PF00098//PF14634//PF02817//PF00097//PF01588//PF08783 2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Ring finger domain//U-box domain//Zinc knuckle//zinc-RING finger domain//e3 binding domain//Zinc finger, C3HC4 type (RING finger)//Putative tRNA binding domain//DWNN domain GO:0008152//GO:0016567 metabolic process//protein ubiquitination GO:0016746//GO:0004842//GO:0000049//GO:0005515//GO:0008270//GO:0003676//GO:0046872 transferase activity, transferring acyl groups//ubiquitin-protein transferase activity//tRNA binding//protein binding//zinc ion binding//nucleic acid binding//metal ion binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.32308 BP_3 39.00 6.68 573 817061123 XP_012252151.1 259 3.4e-20 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.32310 BP_3 31.18 1.38 1383 91083531 XP_973193.1 367 2.5e-32 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q8K354 165 2.7e-10 Carbonyl reductase [NADPH] 3 OS=Mus musculus GN=Cbr3 PE=2 SV=1 PF06112 Gammaherpesvirus capsid protein GO:0055114 oxidation-reduction process GO:0000166//GO:0016491 nucleotide binding//oxidoreductase activity GO:0019028 viral capsid -- -- Cluster-8309.32312 BP_3 934.31 7.29 6465 642924534 XP_008194335.1 2139 3.9e-237 PREDICTED: junctophilin-1 isoform X2 [Tribolium castaneum] 642924533 XM_008196113.1 493 0 PREDICTED: Tribolium castaneum junctophilin-1 (LOC662408), transcript variant X2, mRNA K19530 JPH junctophilin http://www.genome.jp/dbget-bin/www_bget?ko:K19530 Q9ET80 1235 1.1e-133 Junctophilin-1 OS=Mus musculus GN=Jph1 PE=2 SV=1 PF06112//PF04072//PF01022 Gammaherpesvirus capsid protein//Leucine carboxyl methyltransferase//Bacterial regulatory protein, arsR family GO:0006355//GO:0032259 regulation of transcription, DNA-templated//methylation GO:0008168//GO:0003700 methyltransferase activity//transcription factor activity, sequence-specific DNA binding GO:0019028//GO:0005667 viral capsid//transcription factor complex KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.32313 BP_3 342.92 37.20 736 478251713 ENN72167.1 337 4.0e-29 hypothetical protein YQE_11223, partial [Dendroctonus ponderosae]>gi|546680962|gb|ERL91136.1| hypothetical protein D910_08476 [Dendroctonus ponderosae] -- -- -- -- -- K03960 NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03960 -- -- -- -- PF07225 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0015992//GO:0006814//GO:0006744//GO:0006120 proton transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion -- -- Cluster-8309.32316 BP_3 641.14 57.20 832 759040576 XP_011329079.1 207 5.4e-14 PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi]>gi|759040578|ref|XP_011329080.1| PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi]>gi|759040580|ref|XP_011329081.1| PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi]>gi|759040582|ref|XP_011329082.1| PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- O76080 130 1.9e-06 AN1-type zinc finger protein 5 OS=Homo sapiens GN=ZFAND5 PE=1 SV=1 PF01754 A20-like zinc finger -- -- GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- KOG3173 Predicted Zn-finger protein Cluster-8309.32318 BP_3 3.00 0.71 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3232 BP_3 12.18 0.47 1552 642927181 XP_008195169.1 1100 2.8e-117 PREDICTED: synaptic vesicle glycoprotein 2B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZS6 197 5.9e-14 Synaptic vesicle glycoprotein 2C OS=Mus musculus GN=Sv2c PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32321 BP_3 341.00 6.44 2843 642940062 XP_967869.2 1528 1.2e-166 PREDICTED: synembryn-A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29IC2 762 3.3e-79 Synembryn OS=Drosophila pseudoobscura pseudoobscura GN=ric8a PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4464 Signaling protein RIC-8/synembryn (regulates neurotransmitter secretion) Cluster-8309.32322 BP_3 134.12 4.36 1773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32328 BP_3 1428.76 19.06 3904 91095209 XP_968413.1 1384 8.3e-150 PREDICTED: mitochondrial inner membrane protein OXA1L [Tribolium castaneum]>gi|270015977|gb|EFA12425.1| hypothetical protein TcasGA2_TC001816 [Tribolium castaneum] -- -- -- -- -- K03217 yidC, spoIIIJ, OXA1 YidC/Oxa1 family membrane protein insertase http://www.genome.jp/dbget-bin/www_bget?ko:K03217 Q8BGA9 736 4.7e-76 Mitochondrial inner membrane protein OXA1L OS=Mus musculus GN=Oxa1l PE=2 SV=1 PF02096//PF02703 60Kd inner membrane protein//Early E1A protein GO:0006355//GO:0051205//GO:0019048 regulation of transcription, DNA-templated//protein insertion into membrane//modulation by virus of host morphology or physiology -- -- GO:0016021 integral component of membrane KOG3012 Uncharacterized conserved protein Cluster-8309.3233 BP_3 524.75 7.47 3678 91092448 XP_969433.1 4557 0.0e+00 PREDICTED: unconventional myosin-IXa [Tribolium castaneum] 665794026 XM_008546468.1 291 2.86026e-148 PREDICTED: Microplitis demolitor unconventional myosin-IXb (LOC103569255), transcript variant X2, mRNA K16677 DACHS dachs http://www.genome.jp/dbget-bin/www_bget?ko:K16677 O43795 598 4.5e-60 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF00063//PF06414//PF00612 Myosin head (motor domain)//Zeta toxin//IQ calmodulin-binding motif -- -- GO:0003774//GO:0016301//GO:0005524//GO:0005515 motor activity//kinase activity//ATP binding//protein binding GO:0016459 myosin complex KOG0160 Myosin class V heavy chain Cluster-8309.32330 BP_3 1648.40 16.20 5195 91084663 XP_967750.1 2228 1.5e-247 PREDICTED: ubiquitin carboxyl-terminal hydrolase 4 isoform X1 [Tribolium castaneum]>gi|270008628|gb|EFA05076.1| hypothetical protein TcasGA2_TC015173 [Tribolium castaneum] 698430595 XM_009698856.1 46 6.34426e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K11833 USP2_21 ubiquitin carboxyl-terminal hydrolase 2/21 http://www.genome.jp/dbget-bin/www_bget?ko:K11833 O57429 1001 1.2e-106 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF15957//PF12422//PF05427//PF00443 Commissureless//Condensin II non structural maintenance of chromosomes subunit//Acidic fibroblast growth factor binding (FIBP)//Ubiquitin carboxyl-terminal hydrolase GO:0007411//GO:0016579 axon guidance//protein deubiquitination GO:0036459//GO:0017134//GO:0016787 ubiquitinyl hydrolase activity//fibroblast growth factor binding//hydrolase activity GO:0005634 nucleus -- -- Cluster-8309.32331 BP_3 1346.17 11.93 5730 642925017 XP_008194137.1 3852 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X1 [Tribolium castaneum] 462328174 APGK01040787.1 46 7.00218e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.9e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.32332 BP_3 333.21 4.64 3751 91077138 XP_971446.1 1025 3.4e-108 PREDICTED: dnaJ homolog subfamily A member 1 [Tribolium castaneum]>gi|270001716|gb|EEZ98163.1| hypothetical protein TcasGA2_TC000590 [Tribolium castaneum] 817197334 XM_012418859.1 104 2.61669e-44 PREDICTED: Orussus abietinus dnaJ homolog subfamily A member 1 (LOC105696421), transcript variant X2, mRNA K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 P63037 769 6.8e-80 DnaJ homolog subfamily A member 1 OS=Mus musculus GN=Dnaja1 PE=1 SV=1 PF00684//PF01155//PF16685//PF05209//PF00018 DnaJ central domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//zinc RING finger of MSL2//Septum formation inhibitor MinC, N-terminal domain//SH3 domain GO:0006260//GO:0009408//GO:0006464//GO:0006457//GO:0051302 DNA replication//response to heat//cellular protein modification process//protein folding//regulation of cell division GO:0046872//GO:0051082//GO:0061630//GO:0016151//GO:0005515//GO:0005524//GO:0031072 metal ion binding//unfolded protein binding//ubiquitin protein ligase activity//nickel cation binding//protein binding//ATP binding//heat shock protein binding GO:0005737 cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.32333 BP_3 232.00 9.91 1420 91088847 XP_970872.1 1342 2.2e-145 PREDICTED: adenosine kinase [Tribolium castaneum]>gi|270011602|gb|EFA08050.1| hypothetical protein TcasGA2_TC005644 [Tribolium castaneum] -- -- -- -- -- K00856 E2.7.1.20, ADK adenosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00856 P55264 930 5.5e-99 Adenosine kinase OS=Mus musculus GN=Adk PE=1 SV=2 PF00113 Enolase, C-terminal TIM barrel domain GO:0006096//GO:0006144//GO:0006167//GO:0006166//GO:0006094//GO:0009094//GO:0006571//GO:0000162 glycolytic process//purine nucleobase metabolic process//AMP biosynthetic process//purine ribonucleoside salvage//gluconeogenesis//L-phenylalanine biosynthetic process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0004001//GO:0004634//GO:0016773//GO:0000287 adenosine kinase activity//phosphopyruvate hydratase activity//phosphotransferase activity, alcohol group as acceptor//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.32334 BP_3 23.75 0.83 1677 91089445 XP_966341.1 696 2.1e-70 PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|91089447|ref|XP_975797.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|270012573|gb|EFA09021.1| hypothetical protein TcasGA2_TC006730 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q99PT1 419 1.2e-39 Rho GDP-dissociation inhibitor 1 OS=Mus musculus GN=Arhgdia PE=1 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.32335 BP_3 54.57 4.44 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.32336 BP_3 85.31 0.37 11303 478258020 ENN78158.1 1072 3.6e-113 hypothetical protein YQE_05312, partial [Dendroctonus ponderosae] 665797669 XM_008548452.1 38 3.87815e-07 PREDICTED: Microplitis demolitor nucleosomal histone kinase 1-like (LOC103570647), mRNA K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q7KRY6 882 1.6e-92 Nucleosomal histone kinase 1 OS=Drosophila melanogaster GN=ball PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.32337 BP_3 131.24 0.91 7279 478258020 ENN78158.1 1072 2.3e-113 hypothetical protein YQE_05312, partial [Dendroctonus ponderosae] 665797669 XM_008548452.1 38 2.49295e-07 PREDICTED: Microplitis demolitor nucleosomal histone kinase 1-like (LOC103570647), mRNA K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q7KRY6 882 1.0e-92 Nucleosomal histone kinase 1 OS=Drosophila melanogaster GN=ball PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.32338 BP_3 44.24 0.44 5101 546684532 ERL94163.1 2127 7.6e-236 hypothetical protein D910_11445 [Dendroctonus ponderosae] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 641 6.4e-65 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00782 Dual specificity phosphatase, catalytic domain GO:0006470 protein dephosphorylation GO:0008138 protein tyrosine/serine/threonine phosphatase activity -- -- KOG1716 Dual specificity phosphatase Cluster-8309.32339 BP_3 700.15 10.88 3393 642929984 XP_008196053.1 2642 9.7e-296 PREDICTED: atrial natriuretic peptide receptor 1 [Tribolium castaneum] 642929983 XM_008197831.1 317 9.28318e-163 PREDICTED: Tribolium castaneum atrial natriuretic peptide receptor 1 (LOC664507), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18910 1596 7.8e-176 Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus GN=Npr1 PE=1 SV=1 PF07701//PF06330//PF00069//PF07714//PF00211 Heme NO binding associated//Trichodiene synthase (TRI5)//Protein kinase domain//Protein tyrosine kinase//Adenylate and Guanylate cyclase catalytic domain GO:0046039//GO:0006182//GO:0016114//GO:0006144//GO:0006468//GO:0016106//GO:0009190//GO:0035556 GTP metabolic process//cGMP biosynthetic process//terpenoid biosynthetic process//purine nucleobase metabolic process//protein phosphorylation//sesquiterpenoid biosynthetic process//cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0005524//GO:0004383//GO:0016849//GO:0045482//GO:0004672 ATP binding//guanylate cyclase activity//phosphorus-oxygen lyase activity//trichodiene synthase activity//protein kinase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.32340 BP_3 1711.97 47.83 2017 270011245 EFA07693.1 1446 2.8e-157 hypothetical protein TcasGA2_TC030782, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZIF1 469 2.2e-45 Adipocyte plasma membrane-associated protein OS=Gallus gallus GN=APMAP PE=2 SV=1 PF01731//PF01436//PF03088 Arylesterase//NHL repeat//Strictosidine synthase GO:0016114//GO:0009058//GO:0042432 terpenoid biosynthetic process//biosynthetic process//indole biosynthetic process GO:0016844//GO:0004064//GO:0005515 strictosidine synthase activity//arylesterase activity//protein binding -- -- KOG1520 Predicted alkaloid synthase/Surface mucin Hemomucin Cluster-8309.32341 BP_3 1908.85 6.98 13468 189234010 XP_972656.2 5133 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X4 [Tribolium castaneum]>gi|270014736|gb|EFA11184.1| hypothetical protein TcasGA2_TC004792 [Tribolium castaneum] 642911788 XM_967563.3 622 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 O15021 2424 3.0e-271 Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens GN=MAST4 PE=1 SV=3 PF08926//PF00412//PF07714//PF13180//PF00069//PF06293//PF00595 Domain of unknown function (DUF1908)//LIM domain//Protein tyrosine kinase//PDZ domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PDZ domain (Also known as DHR or GLGF) GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0008270//GO:0016773//GO:0000287//GO:0004674//GO:0004672//GO:0005524//GO:0005515 zinc ion binding//phosphotransferase activity, alcohol group as acceptor//magnesium ion binding//protein serine/threonine kinase activity//protein kinase activity//ATP binding//protein binding GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.32342 BP_3 2619.90 9.54 13526 189234010 XP_972656.2 5202 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X4 [Tribolium castaneum]>gi|270014736|gb|EFA11184.1| hypothetical protein TcasGA2_TC004792 [Tribolium castaneum] 642911788 XM_967563.3 622 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 O15021 2428 1.0e-271 Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens GN=MAST4 PE=1 SV=3 PF00069//PF06293//PF00595//PF07714//PF00412//PF13180//PF08926 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PDZ domain (Also known as DHR or GLGF)//Protein tyrosine kinase//LIM domain//PDZ domain//Domain of unknown function (DUF1908) GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0005515//GO:0016773//GO:0008270//GO:0004674//GO:0004672//GO:0000287 ATP binding//protein binding//phosphotransferase activity, alcohol group as acceptor//zinc ion binding//protein serine/threonine kinase activity//protein kinase activity//magnesium ion binding GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.32343 BP_3 26.50 0.58 2486 642914836 XP_008194989.1 590 6.2e-58 PREDICTED: inhibitor of growth protein 3 isoform X2 [Tribolium castaneum] 795091176 XM_012024084.1 94 6.25521e-39 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q5ZK36 398 4.7e-37 Inhibitor of growth protein 3 OS=Gallus gallus GN=ING3 PE=2 SV=1 PF00628//PF04437//PF10280//PF00160//PF08066 PHD-finger//RINT-1 / TIP-1 family//Mediator complex protein//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//PMC2NT (NUC016) domain GO:0006396//GO:0000413//GO:0006357//GO:0048193//GO:0006457 RNA processing//protein peptidyl-prolyl isomerization//regulation of transcription from RNA polymerase II promoter//Golgi vesicle transport//protein folding GO:0003755//GO:0005515//GO:0001104 peptidyl-prolyl cis-trans isomerase activity//protein binding//RNA polymerase II transcription cofactor activity GO:0000176//GO:0005783//GO:0016592 nuclear exosome (RNase complex)//endoplasmic reticulum//mediator complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.32345 BP_3 22.68 3.31 622 642933218 XP_008197312.1 483 4.0e-46 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 269 1.1e-22 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF00083//PF05363 Major Facilitator Superfamily//Sugar (and other) transporter//Herpesvirus US12 family GO:0055085//GO:0019049 transmembrane transport//evasion or tolerance of host defenses by virus GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.32346 BP_3 390.95 3.30 6007 642911031 XP_008193516.1 826 6.5e-85 PREDICTED: cytoplasmic polyadenylation element-binding protein 2 [Tribolium castaneum] 462332955 APGK01039143.1 249 1.0442e-124 Dendroctonus ponderosae Seq01039153, whole genome shotgun sequence K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 Q9VSR3 737 5.6e-76 Probable RNA-binding protein orb2 OS=Drosophila melanogaster GN=orb2 PE=1 SV=1 PF00643//PF16367//PF00076 B-box zinc finger//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular KOG0129 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.32347 BP_3 63.88 0.99 3415 642923285 XP_008193690.1 1709 1.5e-187 PREDICTED: venom dipeptidyl peptidase 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 953 2.8e-101 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF00326//PF02129//PF03583//PF00930 Prolyl oligopeptidase family//X-Pro dipeptidyl-peptidase (S15 family)//Secretory lipase//Dipeptidyl peptidase IV (DPP IV) N-terminal region GO:0006508//GO:0016042//GO:0046486 proteolysis//lipid catabolic process//glycerolipid metabolic process GO:0016787//GO:0008236//GO:0004806 hydrolase activity//serine-type peptidase activity//triglyceride lipase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.32349 BP_3 3.33 0.47 635 546678916 ERL89454.1 149 2.2e-07 hypothetical protein D910_06821 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 142 5.8e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01363//PF13912//PF00096//PF13465 FYVE zinc finger//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.32350 BP_3 741.00 53.93 954 91078168 XP_966793.1 719 2.6e-73 PREDICTED: J domain-containing protein CG6693 [Tribolium castaneum]>gi|270002352|gb|EEZ98799.1| hypothetical protein TcasGA2_TC001365 [Tribolium castaneum] -- -- -- -- -- K09529 DNAJC9 DnaJ homolog subfamily C member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K09529 Q8WXX5 426 1.0e-40 DnaJ homolog subfamily C member 9 OS=Homo sapiens GN=DNAJC9 PE=1 SV=1 PF03461 TRCF domain GO:0006281 DNA repair -- -- -- -- KOG0719 Molecular chaperone (DnaJ superfamily) Cluster-8309.32351 BP_3 177.00 10.57 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32352 BP_3 34.06 0.53 3366 642932460 XP_008197124.1 987 7.8e-104 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase epsilon [Tribolium castaneum] -- -- -- -- -- K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q9R1C6 545 5.7e-54 Diacylglycerol kinase epsilon OS=Mus musculus GN=Dgke PE=2 SV=1 PF00939//PF00130//PF00609 Sodium:sulfate symporter transmembrane region//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain GO:0009395//GO:0007205//GO:0055085//GO:0006810//GO:0006814//GO:0046486//GO:0035556 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//transmembrane transport//transport//sodium ion transport//glycerolipid metabolic process//intracellular signal transduction GO:0004143//GO:0005215 diacylglycerol kinase activity//transporter activity GO:0016020 membrane KOG1169 Diacylglycerol kinase Cluster-8309.32353 BP_3 37.12 0.60 3272 642932460 XP_008197124.1 2101 5.0e-233 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase epsilon [Tribolium castaneum] -- -- -- -- -- K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q9R1C6 967 6.5e-103 Diacylglycerol kinase epsilon OS=Mus musculus GN=Dgke PE=2 SV=1 PF00781//PF00609//PF00130 Diacylglycerol kinase catalytic domain//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0046486//GO:0035556//GO:0007205//GO:0009395 glycerolipid metabolic process//intracellular signal transduction//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process GO:0016301//GO:0004143 kinase activity//diacylglycerol kinase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.32354 BP_3 533.00 6.50 4245 642913805 XP_008201166.1 2763 1.1e-309 PREDICTED: protein wings apart-like isoform X1 [Tribolium castaneum]>gi|270002763|gb|EEZ99210.1| wings apart-like protein [Tribolium castaneum] 662196926 XM_008473295.1 131 2.90238e-59 PREDICTED: Diaphorina citri protein wings apart-like (LOC103508723), mRNA -- -- -- -- Q9W517 1304 7.0e-142 Protein wings apart-like OS=Drosophila melanogaster GN=wapl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2152 Sister chromatid cohesion protein Cluster-8309.32355 BP_3 2458.41 26.20 4814 642924809 XP_008194049.1 4188 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X1 [Tribolium castaneum] 749755570 XM_011141969.1 132 9.16063e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 6.0e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.32359 BP_3 762.84 8.15 4802 546676723 ERL87679.1 1323 1.2e-142 hypothetical protein D910_05069 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24478 594 1.7e-59 Centrosome-associated zinc finger protein CP190 OS=Drosophila melanogaster GN=Cp190 PE=1 SV=2 PF16622//PF00651//PF00096 zinc-finger C2H2-type//BTB/POZ domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.32360 BP_3 157.15 0.93 8408 189233577 XP_968497.2 1756 1.3e-192 PREDICTED: protein capicua homolog isoform X1 [Tribolium castaneum]>gi|270015125|gb|EFA11573.1| capicua [Tribolium castaneum] 642910253 XM_008200351.1 160 4.36723e-75 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X2, mRNA -- -- -- -- Q96RK0 381 1.5e-34 Protein capicua homolog OS=Homo sapiens GN=CIC PE=1 SV=2 PF08288 PIGA (GPI anchor biosynthesis) GO:0006506 GPI anchor biosynthetic process -- -- -- -- KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.32363 BP_3 3294.00 70.37 2548 332376402 AEE63341.1 2678 4.9e-300 unknown [Dendroctonus ponderosae] 642915759 XM_962024.2 567 0 PREDICTED: Tribolium castaneum transmembrane 9 superfamily member 3 (LOC655481), mRNA K17087 TM9SF3 transmembrane 9 superfamily member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17087 Q9ET30 2315 2.5e-259 Transmembrane 9 superfamily member 3 OS=Mus musculus GN=Tm9sf3 PE=1 SV=1 PF02990//PF12297 Endomembrane protein 70//Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- GO:0016021 integral component of membrane KOG1277 Endosomal membrane proteins, EMP70 Cluster-8309.32365 BP_3 35.00 0.89 2180 478256535 ENN76719.1 356 7.4e-31 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 573890600 XM_006632998.1 35 3.43752e-06 PREDICTED: Lepisosteus oculatus zinc finger protein ZIC 5-like (LOC102698757), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 296 2.8e-25 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF02892//PF13912//PF00096//PF02176//PF13465//PF00130 BED zinc finger//C2H2-type zinc finger//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.32366 BP_3 1262.92 10.57 6048 642929749 XP_008195960.1 2131 3.1e-236 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] 242020070 XM_002430435.1 38 2.07019e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF00008//PF06112//PF03067//PF09172//PF05887//PF05433 EGF-like domain//Gammaherpesvirus capsid protein//Chitin binding domain//Domain of unknown function (DUF1943)//Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain GO:0006869 lipid transport GO:0005319//GO:0005515 lipid transporter activity//protein binding GO:0019028//GO:0016020//GO:0019867 viral capsid//membrane//outer membrane -- -- Cluster-8309.32367 BP_3 1010.94 25.98 2167 642915291 XP_008190557.1 1455 2.7e-158 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 676 2.4e-69 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.32368 BP_3 223.71 3.46 3404 642922826 XP_008193342.1 988 6.0e-104 PREDICTED: rhodopsin, GQ-coupled isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P43119 167 3.9e-10 Prostacyclin receptor OS=Homo sapiens GN=PTGIR PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.32374 BP_3 100.00 15.53 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32375 BP_3 370.87 1.03 17722 642928205 XP_008195489.1 16413 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal [Tribolium castaneum] 620960012 XM_007666944.1 166 4.2608e-78 PREDICTED: Ornithorhynchus anatinus dynein, axonemal, heavy chain 10 (DNAH10), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8IVF4 11107 0.0e+00 Dynein heavy chain 10, axonemal OS=Homo sapiens GN=DNAH10 PE=1 SV=4 PF07728//PF15957//PF05197//PF03028//PF02877//PF00004//PF02602//PF03938//PF02562 AAA domain (dynein-related subfamily)//Commissureless//TRIC channel//Dynein heavy chain and region D6 of dynein motor//Poly(ADP-ribose) polymerase, regulatory domain//ATPase family associated with various cellular activities (AAA)//Uroporphyrinogen-III synthase HemD//Outer membrane protein (OmpH-like)//PhoH-like protein GO:0033014//GO:0015994//GO:0006783//GO:0006471//GO:0007018//GO:0007411//GO:0015672//GO:0006812//GO:0007017 tetrapyrrole biosynthetic process//chlorophyll metabolic process//heme biosynthetic process//protein ADP-ribosylation//microtubule-based movement//axon guidance//monovalent inorganic cation transport//cation transport//microtubule-based process GO:0003777//GO:0003950//GO:0005261//GO:0005524//GO:0004852//GO:0051082//GO:0016887 microtubule motor activity//NAD+ ADP-ribosyltransferase activity//cation channel activity//ATP binding//uroporphyrinogen-III synthase activity//unfolded protein binding//ATPase activity GO:0005874//GO:0030286//GO:0016020 microtubule//dynein complex//membrane -- -- Cluster-8309.32378 BP_3 883.69 2.45 17666 270010335 EFA06783.1 17262 0.0e+00 hypothetical protein TcasGA2_TC009719 [Tribolium castaneum] 620960012 XM_007666944.1 166 4.2473e-78 PREDICTED: Ornithorhynchus anatinus dynein, axonemal, heavy chain 10 (DNAH10), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8IVF4 11107 0.0e+00 Dynein heavy chain 10, axonemal OS=Homo sapiens GN=DNAH10 PE=1 SV=4 PF03028//PF05197//PF02877//PF00004//PF02602//PF07728//PF15957//PF02562 Dynein heavy chain and region D6 of dynein motor//TRIC channel//Poly(ADP-ribose) polymerase, regulatory domain//ATPase family associated with various cellular activities (AAA)//Uroporphyrinogen-III synthase HemD//AAA domain (dynein-related subfamily)//Commissureless//PhoH-like protein GO:0006812//GO:0007017//GO:0015672//GO:0007018//GO:0007411//GO:0006471//GO:0006783//GO:0033014//GO:0015994 cation transport//microtubule-based process//monovalent inorganic cation transport//microtubule-based movement//axon guidance//protein ADP-ribosylation//heme biosynthetic process//tetrapyrrole biosynthetic process//chlorophyll metabolic process GO:0016887//GO:0004852//GO:0005524//GO:0005261//GO:0003950//GO:0003777 ATPase activity//uroporphyrinogen-III synthase activity//ATP binding//cation channel activity//NAD+ ADP-ribosyltransferase activity//microtubule motor activity GO:0016020//GO:0030286//GO:0005874 membrane//dynein complex//microtubule -- -- Cluster-8309.32379 BP_3 19.44 0.59 1880 91085239 XP_973002.1 1470 4.3e-160 PREDICTED: 26S proteasome non-ATPase regulatory subunit 13 [Tribolium castaneum]>gi|270009093|gb|EFA05541.1| hypothetical protein TcasGA2_TC015728 [Tribolium castaneum] -- -- -- -- -- K03039 PSMD13, RPN9 26S proteasome regulatory subunit N9 http://www.genome.jp/dbget-bin/www_bget?ko:K03039 P84169 878 7.8e-93 26S proteasome non-ATPase regulatory subunit 13 OS=Gallus gallus GN=PSMD13 PE=1 SV=1 PF00616//PF01399 GTPase-activator protein for Ras-like GTPase//PCI domain GO:0043087 regulation of GTPase activity GO:0005515 protein binding -- -- KOG2908 26S proteasome regulatory complex, subunit RPN9/PSMD13 Cluster-8309.3238 BP_3 45.69 0.89 2755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32383 BP_3 174.36 10.33 1105 736247237 XP_010786870.1 142 2.4e-06 PREDICTED: golgin subfamily A member 6-like protein 22 [Notothenia coriiceps] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32385 BP_3 39.53 0.38 5334 390362249 XP_001190749.2 755 9.8e-77 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 713 3.0e-73 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.32386 BP_3 63.69 60.37 335 91083251 XP_974045.1 525 2.9e-51 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 780659103 XM_011694063.1 116 4.54408e-52 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 471 2.2e-46 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF00270 DEAD/DEAH box helicase -- -- GO:0003676//GO:0005524//GO:0008026 nucleic acid binding//ATP binding//ATP-dependent helicase activity -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.32387 BP_3 149.06 13.45 826 332376787 AEE63533.1 838 3.6e-87 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 617645164 XM_007532444.1 182 2.43686e-88 PREDICTED: Erinaceus europaeus DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A (DDX39A), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 804 1.3e-84 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.32388 BP_3 1450.95 86.74 1098 332376787 AEE63533.1 700 4.8e-71 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 617645164 XM_007532444.1 165 9.23197e-79 PREDICTED: Erinaceus europaeus DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A (DDX39A), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 666 1.7e-68 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.3239 BP_3 3.00 0.81 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32390 BP_3 7.11 0.70 785 91086139 XP_968980.1 363 4.1e-32 PREDICTED: uncharacterized protein LOC657426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02952 L-fucose isomerase, C-terminal domain GO:0006004//GO:0006000//GO:0006013 fucose metabolic process//fructose metabolic process//mannose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm -- -- Cluster-8309.32391 BP_3 35.89 3.18 835 91086139 XP_968980.1 363 4.4e-32 PREDICTED: uncharacterized protein LOC657426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02952 L-fucose isomerase, C-terminal domain GO:0006000//GO:0006013//GO:0006004 fructose metabolic process//mannose metabolic process//fucose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm -- -- Cluster-8309.32395 BP_3 32.10 0.53 3214 546684320 ERL94025.1 191 1.5e-11 hypothetical protein D910_11309 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32398 BP_3 401.45 10.71 2098 332375618 AEE62950.1 1358 4.6e-147 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02175 BRN putative enzyme (brainiac) http://www.genome.jp/dbget-bin/www_bget?ko:K02175 Q24157 635 1.3e-64 Beta-1,3-galactosyltransferase brn OS=Drosophila melanogaster GN=brn PE=2 SV=2 PF12919//PF01762//PF02434//PF11365 TcdA/TcdB catalytic glycosyltransferase domain//Galactosyltransferase//Fringe-like//Protein of unknown function (DUF3166) GO:0006486//GO:0010506 protein glycosylation//regulation of autophagy GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020//GO:0005615 membrane//extracellular space -- -- Cluster-8309.32399 BP_3 315.89 2.29 6927 91091256 XP_968850.1 1918 1.8e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.6e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF00180//PF04117//PF01398 Isocitrate/isopropylmalate dehydrogenase//Mpv17 / PMP22 family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0006102//GO:0006749//GO:0019643//GO:0006099//GO:0055114 isocitrate metabolic process//glutathione metabolic process//reductive tricarboxylic acid cycle//tricarboxylic acid cycle//oxidation-reduction process GO:0016616//GO:0051287//GO:0005515//GO:0004450//GO:0000287 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//protein binding//isocitrate dehydrogenase (NADP+) activity//magnesium ion binding GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.32400 BP_3 23.68 5.15 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32401 BP_3 3.18 0.48 608 642937451 XP_008198841.1 326 6.2e-28 PREDICTED: protein tramtrack, beta isoform-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32402 BP_3 1754.98 63.83 1617 663070911 NP_001284604.1 1060 1.3e-112 ras-related protein Rab-7a [Tribolium castaneum]>gi|642930896|ref|XP_008196131.1| PREDICTED: ras-related protein Rab-7a [Tribolium castaneum]>gi|629511287|gb|AHY84717.1| ras-related protein Rab-7a [Tribolium castaneum] -- -- -- -- -- K07897 RAB7A Ras-related protein Rab-7A http://www.genome.jp/dbget-bin/www_bget?ko:K07897 P09527 880 3.9e-93 Ras-related protein Rab-7a OS=Rattus norvegicus GN=Rab7a PE=1 SV=2 PF03193//PF01637//PF04670//PF00071//PF00735//PF08477//PF01926//PF00025 Protein of unknown function, DUF258//Archaeal ATPase//Gtr1/RagA G protein conserved region//Ras family//Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding -- -- KOG0394 Ras-related GTPase Cluster-8309.32403 BP_3 123.00 7.04 1134 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32404 BP_3 232.00 37.74 588 91090444 XP_966925.1 587 3.3e-58 PREDICTED: DNA-directed RNA polymerase II subunit RPB11 [Tribolium castaneum]>gi|270013848|gb|EFA10296.1| hypothetical protein TcasGA2_TC012511 [Tribolium castaneum] -- -- -- -- -- K03008 RPB11, POLR2J DNA-directed RNA polymerase II subunit RPB11 http://www.genome.jp/dbget-bin/www_bget?ko:K03008 Q9VJE4 549 3.4e-55 DNA-directed RNA polymerase II subunit RPB11 OS=Drosophila melanogaster GN=Rpb11 PE=3 SV=1 PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046983 DNA binding//DNA-directed RNA polymerase activity//protein dimerization activity GO:0005730 nucleolus KOG4392 RNA polymerase, subunit L Cluster-8309.32406 BP_3 210.00 12.34 1112 674304018 AIL23540.1 547 2.7e-53 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 408 1.5e-38 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 PF02798//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32409 BP_3 846.00 22.22 2127 478253644 ENN73948.1 447 2.0e-41 hypothetical protein YQE_09450, partial [Dendroctonus ponderosae]>gi|546684551|gb|ERL94179.1| hypothetical protein D910_11461 [Dendroctonus ponderosae] -- -- -- -- -- K14527 RPP20, POP7 ribonuclease P/MRP protein subunit RPP20 http://www.genome.jp/dbget-bin/www_bget?ko:K14527 Q969S6 233 5.5e-18 Transmembrane protein 203 OS=Homo sapiens GN=TMEM203 PE=2 SV=1 PF12861//PF12328//PF04564//PF02891//PF11789//PF01918 Anaphase-promoting complex subunit 11 RING-H2 finger//Rpp20 subunit of nuclear RNase MRP and P//U-box domain//MIZ/SP-RING zinc finger//Zinc-finger of the MIZ type in Nse subunit//Alba GO:0051252//GO:0008033//GO:0016567 regulation of RNA metabolic process//tRNA processing//protein ubiquitination GO:0003676//GO:0008270//GO:0004842//GO:0004526 nucleic acid binding//zinc ion binding//ubiquitin-protein transferase activity//ribonuclease P activity GO:0005680//GO:0030677//GO:0005634 anaphase-promoting complex//ribonuclease P complex//nucleus KOG2979 Protein involved in DNA repair Cluster-8309.32410 BP_3 569.45 5.99 4875 642935314 XP_008197964.1 2079 2.7e-230 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X13 [Tribolium castaneum] 780158183 XM_011684374.1 51 9.8875e-15 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 O42184 1135 3.2e-122 CAP-Gly domain-containing linker protein 1 OS=Gallus gallus GN=CLIP1 PE=2 SV=1 PF00038//PF10186 Intermediate filament protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy GO:0005198 structural molecule activity GO:0005882 intermediate filament -- -- Cluster-8309.32411 BP_3 837.00 16.96 2671 91091768 XP_969459.1 560 2.0e-54 PREDICTED: CDGSH iron-sulfur domain-containing protein 2 homolog [Tribolium castaneum]>gi|270001086|gb|EEZ97533.1| hypothetical protein TcasGA2_TC011381 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JYJ2 499 9.8e-49 CDGSH iron-sulfur domain-containing protein 2 homolog OS=Drosophila grimshawi GN=GH14305 PE=3 SV=1 PF10660//PF09360 Iron-containing outer mitochondrial membrane protein N-terminus//Iron-binding zinc finger CDGSH type -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG3461 CDGSH-type Zn-finger containing protein Cluster-8309.32413 BP_3 388.35 63.38 587 546677100 ERL88001.1 626 9.8e-63 hypothetical protein D910_05390 [Dendroctonus ponderosae] 641661239 XM_008183586.1 194 3.63134e-95 PREDICTED: Acyrthosiphon pisum chromatin modifying protein 2A (Chmp2a), transcript variant X7, mRNA K12191 CHMP2A charged multivesicular body protein 2A http://www.genome.jp/dbget-bin/www_bget?ko:K12191 Q6IP52 544 1.3e-54 Charged multivesicular body protein 2a OS=Xenopus laevis GN=chmp2a PE=2 SV=1 PF01346//PF03357//PF11698 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Snf7//V-ATPase subunit H GO:0007034//GO:0015991//GO:0006457 vacuolar transport//ATP hydrolysis coupled proton transport//protein folding GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.32414 BP_3 83.34 0.80 5314 769848297 XP_011635512.1 1496 1.2e-162 PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus]>gi|769848299|ref|XP_011635513.1| PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus] 572314861 XM_006623032.1 428 0 PREDICTED: Apis dorsata developmentally-regulated GTP-binding protein 2-like (LOC102680357), transcript variant X1, mRNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 1333 3.8e-145 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF03006//PF02421//PF03193//PF00176//PF01926 Haemolysin-III related//Ferrous iron transport protein B//Protein of unknown function, DUF258//SNF2 family N-terminal domain//50S ribosome-binding GTPase GO:0015684 ferrous iron transport GO:0003924//GO:0005525//GO:0005524//GO:0015093 GTPase activity//GTP binding//ATP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.32417 BP_3 6.66 0.31 1321 642933527 XP_008197456.1 275 1.1e-21 PREDICTED: protein alan shepard isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3242 BP_3 219.94 46.21 521 91091644 XP_970770.1 263 1.1e-20 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000890|gb|EEZ97337.1| hypothetical protein TcasGA2_TC011149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 198 1.5e-14 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.32420 BP_3 5901.56 235.42 1500 91093044 XP_966517.1 1581 4.6e-173 PREDICTED: lysosomal aspartic protease [Tribolium castaneum]>gi|270002651|gb|EEZ99098.1| hypothetical protein TcasGA2_TC004989 [Tribolium castaneum] 17981529 AF454831.1 697 0 AF454831 Apriona germari cathepsin D mRNA, complete cds K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 1436 1.2e-157 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF07966//PF00026 A1 Propeptide//Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG1339 Aspartyl protease Cluster-8309.32421 BP_3 33.94 1.02 1891 329754204 AEC03508.1 1158 6.5e-124 cathepsin-D [Polyrhachis vicina] 17981529 AF454831.1 494 0 AF454831 Apriona germari cathepsin D mRNA, complete cds K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 1096 4.1e-118 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF07966//PF00026 A1 Propeptide//Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG1339 Aspartyl protease Cluster-8309.32425 BP_3 218.00 43.17 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09604//PF01741 F subunit of K+-transporting ATPase (Potass_KdpF)//Large-conductance mechanosensitive channel, MscL GO:0006813//GO:0006810//GO:0043462//GO:0006811 potassium ion transport//transport//regulation of ATPase activity//ion transport GO:0008556//GO:0005216 potassium-transporting ATPase activity//ion channel activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.32426 BP_3 5647.84 67.70 4313 91094647 XP_971886.1 3678 0.0e+00 PREDICTED: protein transport protein Sec24C [Tribolium castaneum]>gi|270016466|gb|EFA12912.1| hypothetical protein TcasGA2_TC006982 [Tribolium castaneum] 751205538 XM_011178054.1 47 1.46237e-12 PREDICTED: Solenopsis invicta protein transport protein Sec24C (LOC105208248), mRNA K14007 SEC24 protein transport protein SEC24 http://www.genome.jp/dbget-bin/www_bget?ko:K14007 P53992 2462 3.8e-276 Protein transport protein Sec24C OS=Homo sapiens GN=SEC24C PE=1 SV=3 PF04811//PF04810//PF04815 Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1984 Vesicle coat complex COPII, subunit SFB3 Cluster-8309.32427 BP_3 34.33 0.60 3064 546682375 ERL92317.1 1068 2.9e-113 hypothetical protein D910_09634 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V771 749 1.2e-77 Probable cytochrome P450 6a23 OS=Drosophila melanogaster GN=Cyp6a23 PE=2 SV=2 PF02428//PF00067 Potato type II proteinase inhibitor family//Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0004867//GO:0020037//GO:0016705 iron ion binding//serine-type endopeptidase inhibitor activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.32428 BP_3 1996.00 27.27 3820 478256803 ENN76978.1 958 2.0e-100 hypothetical protein YQE_06473, partial [Dendroctonus ponderosae]>gi|546673971|gb|ERL85479.1| hypothetical protein D910_02898 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZJH7 413 1.3e-38 Protein CNPPD1 OS=Gallus gallus GN=CNPPD1 PE=2 SV=1 PF05504//PF08613 Spore germination B3/ GerAC like, C-terminal//Cyclin GO:0009847//GO:0000079 spore germination//regulation of cyclin-dependent protein serine/threonine kinase activity GO:0019901 protein kinase binding GO:0016020 membrane -- -- Cluster-8309.32432 BP_3 431.45 9.95 2382 546671969 ERL84051.1 1670 3.5e-183 hypothetical protein D910_01380 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9GYU8 747 1.5e-77 Nuclear pore complex protein Nup88 OS=Drosophila melanogaster GN=mbo PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32433 BP_3 1074.39 44.86 1446 817065788 XP_012254705.1 1861 1.5e-205 PREDICTED: eukaryotic initiation factor 4A-III [Athalia rosae] 642929692 XM_970418.2 426 0 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4A-III (LOC664411), mRNA K13025 EIF4A3, FAL1 ATP-dependent RNA helicase http://www.genome.jp/dbget-bin/www_bget?ko:K13025 A6M931 1772 1.3e-196 Eukaryotic initiation factor 4A-III OS=Sus scrofa GN=EIF4A3 PE=2 SV=1 PF06862//PF00270//PF04851//PF00580 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//UvrD/REP helicase N-terminal domain -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding GO:0005634 nucleus KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily Cluster-8309.32434 BP_3 117.00 35.53 450 -- -- -- -- -- 778682640 XM_004148526.2 56 1.41707e-18 PREDICTED: Cucumis sativus eukaryotic initiation factor 4A-3 (LOC101222664), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32436 BP_3 6.15 0.90 623 642937505 XP_008198869.1 223 5.6e-16 PREDICTED: protein tramtrack, beta isoform-like isoform X29 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32437 BP_3 50.78 2.40 1313 642935018 XP_968403.2 1137 1.2e-121 PREDICTED: WD repeat-containing protein 91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZLL7 523 7.9e-52 WD repeat-containing protein 91 OS=Gallus gallus GN=WDR91 PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.32439 BP_3 46.79 0.63 3889 642926882 XP_008195051.1 2942 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 isoform X3 [Tribolium castaneum] 759064686 XM_011343453.1 68 2.79178e-24 PREDICTED: Cerapachys biroi probable cation-transporting ATPase 13A3 (LOC105281898), transcript variant X2, mRNA K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 1454 2.6e-159 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF00122 P5-type ATPase cation transporter//E1-E2 ATPase GO:0006812 cation transport GO:0046872//GO:0000166//GO:0016887 metal ion binding//nucleotide binding//ATPase activity GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.32441 BP_3 266.00 17.60 1020 91083327 XP_974883.1 1200 4.7e-129 PREDICTED: 39S ribosomal protein L15, mitochondrial [Tribolium castaneum]>gi|270007756|gb|EFA04204.1| hypothetical protein TcasGA2_TC014453 [Tribolium castaneum] 820844262 XM_003692379.2 89 1.51494e-36 PREDICTED: Apis florea 39S ribosomal protein L15, mitochondrial (LOC100868950), mRNA K02876 RP-L15, MRPL15, rplO large subunit ribosomal protein L15 http://www.genome.jp/dbget-bin/www_bget?ko:K02876 Q5ZKT8 755 7.7e-79 39S ribosomal protein L15, mitochondrial OS=Gallus gallus GN=MRPL15 PE=2 SV=1 -- -- GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit KOG0846 Mitochondrial/chloroplast ribosomal protein L15/L10 Cluster-8309.32442 BP_3 19.00 2.39 675 701219148 AIV43008.1 610 8.1e-61 pheromone binding protein PBP1 [Batocera horsfieldi] 701219147 KM222577.1 402 0 Batocera horsfieldi pheromone binding protein PBP1 mRNA, complete cds -- -- -- -- P54193 190 1.7e-13 General odorant-binding protein 83a OS=Drosophila melanogaster GN=Obp83a PE=1 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.32444 BP_3 131.21 4.82 1603 642926100 XP_008194784.1 875 3.6e-91 PREDICTED: polycomb complex protein BMI-1-A [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 Q91648 604 3.9e-61 Polycomb complex protein BMI-1-A OS=Xenopus laevis GN=bmi1a PE=1 SV=1 PF13639//PF03315//PF03854//PF01213//PF10099//PF03341//PF11789//PF00097//PF12678//PF14634 Ring finger domain//Serine dehydratase beta chain//P-11 zinc finger//Adenylate cyclase associated (CAP) N terminal//Anti-sigma-K factor rskA//Poxvirus mRNA capping enzyme, small subunit//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain GO:0006094//GO:0006566//GO:0006534//GO:0007010//GO:0006563//GO:0006544//GO:0006370//GO:0009451 gluconeogenesis//threonine metabolic process//cysteine metabolic process//cytoskeleton organization//L-serine metabolic process//glycine metabolic process//7-methylguanosine mRNA capping//RNA modification GO:0051539//GO:0003941//GO:0008270//GO:0003779//GO:0046872//GO:0005515//GO:0003723//GO:0004482 4 iron, 4 sulfur cluster binding//L-serine ammonia-lyase activity//zinc ion binding//actin binding//metal ion binding//protein binding//RNA binding//mRNA (guanine-N7-)-methyltransferase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2660 Locus-specific chromosome binding proteins Cluster-8309.32445 BP_3 9.94 0.36 1607 642928322 XP_008195533.1 577 1.3e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.3e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.32446 BP_3 99.84 3.04 1876 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32449 BP_3 713.63 5.25 6846 332376224 AEE63252.1 1345 4.9e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 Q9Y4P3 750 2.0e-77 Transducin beta-like protein 2 OS=Homo sapiens GN=TBL2 PE=1 SV=1 PF01612//PF00930//PF00400 3'-5' exonuclease//Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006139//GO:0006508 nucleobase-containing compound metabolic process//proteolysis GO:0005515//GO:0008408//GO:0003676 protein binding//3'-5' exonuclease activity//nucleic acid binding -- -- KOG2248 3'-5' exonuclease Cluster-8309.32450 BP_3 1013.87 11.46 4555 642920007 XP_975159.2 1845 3.4e-203 PREDICTED: stromal interaction molecule homolog isoform X2 [Tribolium castaneum]>gi|270005983|gb|EFA02431.1| hypothetical protein TcasGA2_TC008118 [Tribolium castaneum] -- -- -- -- -- K16059 STIM1 stromal interaction molecule 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16059 P83094 1377 2.6e-150 Stromal interaction molecule homolog OS=Drosophila melanogaster GN=Stim PE=1 SV=1 PF05478//PF02203//PF15291//PF00536//PF07647//PF05384//PF07926//PF10473 Prominin//Tar ligand binding domain homologue//Dermcidin, antibiotic peptide//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sensor protein DegS//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006935//GO:0006606//GO:0031640//GO:0007165 chemotaxis//protein import into nucleus//killing of cells of other organism//signal transduction GO:0042803//GO:0004888//GO:0005515//GO:0016301//GO:0008233//GO:0008134//GO:0045502 protein homodimerization activity//transmembrane signaling receptor activity//protein binding//kinase activity//peptidase activity//transcription factor binding//dynein binding GO:0016020//GO:0005576//GO:0030286//GO:0005667//GO:0016021 membrane//extracellular region//dynein complex//transcription factor complex//integral component of membrane KOG4403 Cell surface glycoprotein STIM, contains SAM domain Cluster-8309.32452 BP_3 49.89 3.26 1030 642930199 XP_969558.2 351 1.3e-30 PREDICTED: uncharacterized protein LOC658052 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17122//PF06807 Zinc-finger//Pre-mRNA cleavage complex II protein Clp1 GO:0031124 mRNA 3'-end processing GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.32456 BP_3 38.23 4.88 669 642931818 XP_008196746.1 346 3.3e-30 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 282 3.6e-24 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF00958 GMP synthase C terminal domain GO:0006164//GO:0006144//GO:0006536//GO:0006177 purine nucleotide biosynthetic process//purine nucleobase metabolic process//glutamate metabolic process//GMP biosynthetic process GO:0005524//GO:0003922 ATP binding//GMP synthase (glutamine-hydrolyzing) activity -- -- KOG1622 GMP synthase Cluster-8309.32459 BP_3 1602.00 20.95 3978 478257031 ENN77195.1 1576 4.6e-172 hypothetical protein YQE_06333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q08379 338 6.8e-30 Golgin subfamily A member 2 OS=Homo sapiens GN=GOLGA2 PE=1 SV=3 PF06422//PF04508//PF15070 CDR ABC transporter//Viral A-type inclusion protein repeat//Putative golgin subfamily A member 2-like protein 5 GO:0006810//GO:0016032 transport//viral process GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG4725 Uncharacterized conserved protein Cluster-8309.3246 BP_3 3.00 0.42 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32461 BP_3 17.70 0.40 2447 170060164 XP_001865682.1 188 2.5e-11 galactose-specific C-type lectin [Culex quinquefasciatus]>gi|167878689|gb|EDS42072.1| galactose-specific C-type lectin [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32462 BP_3 858.68 27.08 1820 642937660 XP_008198889.1 867 3.5e-90 PREDICTED: tetraspanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17353 TSPAN18 tetraspanin-18 http://www.genome.jp/dbget-bin/www_bget?ko:K17353 Q6AYR9 287 2.6e-24 Tetraspanin-1 OS=Rattus norvegicus GN=Tspan1 PE=2 SV=1 PF01788//PF00335 PsbJ//Tetraspanin family GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020//GO:0016021 photosystem II//photosystem II reaction center//membrane//integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.32463 BP_3 244.82 4.71 2799 270012323 EFA08771.1 360 3.3e-31 hypothetical protein TcasGA2_TC006460 [Tribolium castaneum] -- -- -- -- -- K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q19529 245 2.9e-19 Probable calcium-binding mitochondrial carrier F17E5.2 OS=Caenorhabditis elegans GN=F17E5.2 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG0036 Predicted mitochondrial carrier protein Cluster-8309.32464 BP_3 201.91 6.35 1824 642923711 XP_974199.2 2254 5.1e-251 PREDICTED: protein smg8 [Tribolium castaneum] -- -- -- -- -- K18734 SMG8 protein SMG8 http://www.genome.jp/dbget-bin/www_bget?ko:K18734 B0W730 645 7.9e-66 Protein SMG8 OS=Culex quinquefasciatus GN=CPIJ003128 PE=3 SV=1 PF08653//PF10220 DASH complex subunit Dam1//Uncharacterized conserved protein (DUF2146) GO:0008608//GO:0000184 attachment of spindle microtubules to kinetochore//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex KOG3692 Uncharacterized conserved protein Cluster-8309.32466 BP_3 30931.65 1813.15 1114 270297210 NP_001161910.1 1080 4.2e-115 cuticular protein analogous to peritrophins 3-A1 precursor [Tribolium castaneum]>gi|268309018|gb|ACY95475.1| cuticular protein analogous to peritrophins 3-A1 [Tribolium castaneum]>gi|270000882|gb|EEZ97329.1| hypothetical protein TcasGA2_TC011140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.32468 BP_3 765.00 167.28 512 642929535 XP_008195878.1 435 1.2e-40 PREDICTED: cytochrome b-c1 complex subunit 7 [Tribolium castaneum]>gi|270011087|gb|EFA07535.1| hypothetical protein TcasGA2_TC009966 [Tribolium castaneum] -- -- -- -- -- K00417 QCR7, UQCRB ubiquinol-cytochrome c reductase subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00417 Q5RC24 317 2.4e-28 Cytochrome b-c1 complex subunit 7 OS=Pongo abelii GN=UQCRB PE=3 SV=3 PF02271 Ubiquinol-cytochrome C reductase complex 14kD subunit GO:0006122//GO:0006118//GO:0015992//GO:0006119 mitochondrial electron transport, ubiquinol to cytochrome c//obsolete electron transport//proton transport//oxidative phosphorylation GO:0008121 ubiquinol-cytochrome-c reductase activity GO:0005750 mitochondrial respiratory chain complex III KOG3440 Ubiquinol cytochrome c reductase, subunit QCR7 Cluster-8309.32469 BP_3 134.56 2.04 3478 91088287 XP_968620.1 2906 0.0e+00 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [Tribolium castaneum]>gi|270012778|gb|EFA09226.1| hypothetical protein TcasGA2_TC006271 [Tribolium castaneum] 830244945 XM_012734906.1 514 0 PREDICTED: Condylura cristata succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), mRNA K00234 SDHA, SDH1 succinate dehydrogenase (ubiquinone) flavoprotein subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00234 Q9YHT1 2618 2.5e-294 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Gallus gallus GN=SDHA PE=1 SV=2 PF07992//PF01266//PF01494//PF02910//PF01134 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//FAD binding domain//Fumarate reductase flavoprotein C-term//Glucose inhibited division protein A GO:0008033//GO:0055114//GO:0006099//GO:0022900 tRNA processing//oxidation-reduction process//tricarboxylic acid cycle//electron transport chain GO:0016627//GO:0050660//GO:0016491//GO:0071949 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity//FAD binding -- -- KOG2403 Succinate dehydrogenase, flavoprotein subunit Cluster-8309.3247 BP_3 8.00 1.99 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32470 BP_3 418.01 11.40 2059 642915063 XP_008190394.1 1382 7.5e-150 PREDICTED: acyl-CoA dehydrogenase family member 9, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZN5 631 3.7e-64 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 PF00441//PF02771//PF02770//PF09057 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Second Mitochondria-derived Activator of Caspases GO:0008152//GO:0055114//GO:0006915//GO:0006919//GO:0006118 metabolic process//oxidation-reduction process//apoptotic process//activation of cysteine-type endopeptidase activity involved in apoptotic process//obsolete electron transport GO:0003995//GO:0016627//GO:0050660 acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding GO:0005739 mitochondrion KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.32471 BP_3 3762.00 35.86 5348 91079092 XP_975294.1 3398 0.0e+00 PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916387|ref|XP_008191000.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916389|ref|XP_008191001.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916391|ref|XP_008191002.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916393|ref|XP_008191003.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|270003651|gb|EFA00099.1| hypothetical protein TcasGA2_TC002914 [Tribolium castaneum] 642916394 XM_970201.3 683 0 PREDICTED: Tribolium castaneum irregular chiasm C-roughest protein (LOC664188), transcript variant X5, mRNA -- -- -- -- Q08180 1769 1.1e-195 Irregular chiasm C-roughest protein OS=Drosophila melanogaster GN=rst PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.32472 BP_3 9142.30 315.14 1690 332375414 AEE62848.1 1924 8.7e-213 unknown [Dendroctonus ponderosae]>gi|478252245|gb|ENN72673.1| hypothetical protein YQE_10771, partial [Dendroctonus ponderosae]>gi|546675733|gb|ERL86865.1| hypothetical protein D910_04268 [Dendroctonus ponderosae] 751469686 XM_011191737.1 379 0 PREDICTED: Bactrocera cucurbitae enolase (LOC105216959), mRNA K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 P15007 1744 2.7e-193 Enolase OS=Drosophila melanogaster GN=Eno PE=1 SV=2 PF00113//PF03952//PF00817 Enolase, C-terminal TIM barrel domain//Enolase, N-terminal domain//impB/mucB/samB family GO:0006096//GO:0006281//GO:0006094//GO:0009094//GO:0000162//GO:0006571 glycolytic process//DNA repair//gluconeogenesis//L-phenylalanine biosynthetic process//tryptophan biosynthetic process//tyrosine biosynthetic process GO:0004634//GO:0000287 phosphopyruvate hydratase activity//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-8309.32474 BP_3 8.04 0.48 1103 602672786 XP_007441894.1 332 2.3e-28 PREDICTED: 60S ribosomal protein L3-like, partial [Python bivittatus] 532165023 KF018925.1 71 1.66588e-26 Aphis gossypii 60S ribosomal protein L3 mRNA, complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 263 9.4e-22 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.32475 BP_3 30.03 1.21 1489 861652644 KMQ98436.1 372 7.1e-33 60s ribosomal protein l3 [Lasius niger] 268306351 GU084264.1 102 1.32522e-43 Manduca sexta ribosomal protein L3 (rpl3) mRNA, complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 359 9.4e-33 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF10389//PF00297 Bacteriophage coat protein B//Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0019028 intracellular//ribosome//viral capsid KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.32476 BP_3 113.93 1.48 3999 646696398 KDR08721.1 1292 4.0e-139 Nucleolar protein 14 [Zootermopsis nevadensis] -- -- -- -- -- K14766 NOP14, UTP2 nucleolar protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K14766 Q9VEJ2 921 1.7e-97 Nucleolar protein 14 homolog OS=Drosophila melanogaster GN=l(3)07882 PE=2 SV=2 PF15549//PF04147//PF05859//PF08361 PGC7/Stella/Dppa3 domain//Nop14-like family//Mis12 protein//MAATS-type transcriptional repressor, C-terminal region GO:0007067//GO:0007049 mitotic nuclear division//cell cycle GO:0003677//GO:0035064 DNA binding//methylated histone binding GO:0005634//GO:0000775//GO:0032040 nucleus//chromosome, centromeric region//small-subunit processome KOG2147 Nucleolar protein involved in 40S ribosome biogenesis Cluster-8309.32477 BP_3 320.00 11.04 1689 91092926 XP_971772.1 204 2.4e-13 PREDICTED: brain protein I3 [Tribolium castaneum]>gi|270003102|gb|EEZ99549.1| hypothetical protein TcasGA2_TC000131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28662 128 6.5e-06 Brain protein I3 OS=Mus musculus GN=Bri3 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32478 BP_3 319.00 15.33 1295 332375134 AEE62708.1 547 3.1e-53 unknown [Dendroctonus ponderosae]>gi|478270808|gb|ENN83562.1| hypothetical protein YQE_00085, partial [Dendroctonus ponderosae]>gi|546673460|gb|ERL85058.1| hypothetical protein D910_02481 [Dendroctonus ponderosae] 805798271 XM_012288404.1 100 1.48555e-42 PREDICTED: Megachile rotundata dynein light chain Tctex-type 1 (LOC100879789), transcript variant X2, mRNA K10420 DYNLT dynein light chain Tctex-type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10420 Q94524 440 3.3e-42 Dynein light chain Tctex-type OS=Drosophila melanogaster GN=Dlc90F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4081 Dynein light chain Cluster-8309.32479 BP_3 478.30 5.37 4584 642923911 XP_008193924.1 2383 1.4e-265 PREDICTED: nucleolar protein 10 [Tribolium castaneum]>gi|270007790|gb|EFA04238.1| hypothetical protein TcasGA2_TC014492 [Tribolium castaneum] 817185075 XM_012429433.1 102 4.14388e-43 PREDICTED: Orussus abietinus nucleolar protein 10 (LOC105702116), transcript variant X1, mRNA K14788 NOL10, ENP2 ribosome biogenesis protein ENP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14788 Q7T0Q5 1808 2.7e-200 Nucleolar protein 10 OS=Xenopus laevis GN=nol10 PE=2 SV=1 PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus KOG2321 WD40 repeat protein Cluster-8309.32480 BP_3 26.46 0.83 1836 734641965 XP_010749894.1 426 4.8e-39 PREDICTED: zinc finger protein 135-like [Larimichthys crocea] -- -- -- -- -- -- -- -- -- Q6ZMW2 404 7.0e-38 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13465//PF00096//PF01363//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//FYVE zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.32481 BP_3 281.43 8.43 1900 642919169 XP_008191766.1 1427 4.2e-155 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q810J8 982 6.9e-105 Zinc finger FYVE domain-containing protein 1 OS=Mus musculus GN=Zfyve1 PE=2 SV=2 PF02263//PF04548//PF01926 Guanylate-binding protein, N-terminal domain//AIG1 family//50S ribosome-binding GTPase -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- -- -- Cluster-8309.32482 BP_3 447.81 20.36 1352 642919171 XP_967331.2 660 2.6e-66 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q5RFL4 488 9.3e-48 Zinc finger FYVE domain-containing protein 1 OS=Pongo abelii GN=ZFYVE1 PE=2 SV=1 PF01667//PF01363//PF08782//PF12678 Ribosomal protein S27//FYVE zinc finger//c-SKI Smad4 binding domain//RING-H2 zinc finger GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008270//GO:0003735//GO:0046332//GO:0046872 zinc ion binding//structural constituent of ribosome//SMAD binding//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.32483 BP_3 301.00 6.08 2679 478254828 ENN75064.1 3423 0.0e+00 hypothetical protein YQE_08377, partial [Dendroctonus ponderosae] 195469995 XM_002099885.1 153 1.07384e-71 Drosophila yakuba GE16763 (Dyak\GE16763), partial mRNA K02542 MCM6 DNA replication licensing factor MCM6 http://www.genome.jp/dbget-bin/www_bget?ko:K02542 Q29JI9 2972 0.0e+00 DNA replication licensing factor Mcm6 OS=Drosophila pseudoobscura pseudoobscura GN=Mcm6 PE=3 SV=1 PF07726//PF07728//PF00158//PF00493//PF05184 ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//MCM2/3/5 family//Saposin-like type B, region 1 GO:0006260//GO:0006355//GO:0006629 DNA replication//regulation of transcription, DNA-templated//lipid metabolic process GO:0016887//GO:0003677//GO:0005524//GO:0008134 ATPase activity//DNA binding//ATP binding//transcription factor binding GO:0005667 transcription factor complex KOG0480 DNA replication licensing factor, MCM6 component Cluster-8309.32485 BP_3 986.33 10.21 4949 642930728 XP_008200003.1 1770 1.8e-194 PREDICTED: sorting nexin-8 [Tribolium castaneum] -- -- -- -- -- K17922 SNX8, MVP1 sorting nexin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K17922 Q2KHV6 733 1.3e-75 Sorting nexin-8 OS=Bos taurus GN=SNX8 PE=2 SV=1 PF00107//PF00787//PF01118 Zinc-binding dehydrogenase//PX domain//Semialdehyde dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016620//GO:0035091//GO:0051287 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//phosphatidylinositol binding//NAD binding -- -- KOG1196 Predicted NAD-dependent oxidoreductase Cluster-8309.32486 BP_3 374.33 7.70 2635 642918946 XP_008191669.1 594 2.3e-58 PREDICTED: transcriptional regulator ATRX homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09036 Bcr-Abl oncoprotein oligomerisation domain GO:0006468//GO:0009069//GO:0016310//GO:0007165 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//signal transduction GO:0004674//GO:0005096 protein serine/threonine kinase activity//GTPase activator activity -- -- -- -- Cluster-8309.32487 BP_3 13.23 0.59 1378 91092240 XP_971305.1 870 1.2e-90 PREDICTED: lysosomal Pro-X carboxypeptidase [Tribolium castaneum]>gi|270014428|gb|EFA10876.1| hypothetical protein TcasGA2_TC001698 [Tribolium castaneum] -- -- -- -- -- K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q2TA14 618 8.0e-63 Lysosomal Pro-X carboxypeptidase OS=Bos taurus GN=PRCP PE=2 SV=1 PF00326//PF10403//PF05577 Prolyl oligopeptidase family//Rad4 beta-hairpin domain 1//Serine carboxypeptidase S28 GO:0006508 proteolysis GO:0003677//GO:0008236 DNA binding//serine-type peptidase activity -- -- KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.32490 BP_3 525.57 2.01 12890 255522799 NP_001157312.1 417 3.7e-37 longitudinals lacking isoform 3 [Tribolium castaneum] 805821658 XM_012295481.1 73 1.54691e-26 PREDICTED: Megachile rotundata zinc finger protein OZF-like (LOC105663827), mRNA -- -- -- -- Q7KQZ4 215 4.0e-15 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF02176//PF00096//PF13465//PF04988 TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.32492 BP_3 550.00 4.12 6724 478259590 ENN79443.1 1869 8.3e-206 hypothetical protein YQE_04087, partial [Dendroctonus ponderosae] 471223427 XM_004030445.1 37 8.2791e-07 Ichthyophthirius multifiliis hypothetical protein (IMG5_159830) mRNA, complete cds K10901 BLM, RECQL3, SGS1 bloom syndrome protein http://www.genome.jp/dbget-bin/www_bget?ko:K10901 Q9VGI8 1306 6.5e-142 Bloom syndrome protein homolog OS=Drosophila melanogaster GN=Blm PE=1 SV=1 PF00270//PF00570//PF09382//PF08503//PF00069//PF07714//PF04851 DEAD/DEAH box helicase//HRDC domain//RQC domain//Tetrahydrodipicolinate succinyltransferase N-terminal//Protein kinase domain//Protein tyrosine kinase//Type III restriction enzyme, res subunit GO:0006281//GO:0042967//GO:0006531//GO:0006468//GO:0006260//GO:0006522 DNA repair//acyl-carrier-protein biosynthetic process//aspartate metabolic process//protein phosphorylation//DNA replication//alanine metabolic process GO:0003677//GO:0016787//GO:0047200//GO:0005524//GO:0003676//GO:0004672//GO:0043140 DNA binding//hydrolase activity//tetrahydrodipicolinate N-acetyltransferase activity//ATP binding//nucleic acid binding//protein kinase activity//ATP-dependent 3'-5' DNA helicase activity GO:0005657//GO:0005622 replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.32493 BP_3 880.99 9.65 4693 642920083 XP_008192197.1 1427 1.0e-154 PREDICTED: glycogen synthase kinase-3 beta isoform X2 [Tribolium castaneum] 642920086 XM_008193977.1 296 6.07698e-151 PREDICTED: Tribolium castaneum shaggy (LOC664299), transcript variant X4, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P18431 1208 1.1e-130 Protein kinase shaggy OS=Drosophila melanogaster GN=sgg PE=1 SV=3 PF06293//PF00069//PF07714//PF14552 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Tautomerase enzyme GO:0006725//GO:0006468 cellular aromatic compound metabolic process//protein phosphorylation GO:0004672//GO:0016853//GO:0005524//GO:0016773 protein kinase activity//isomerase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0658 Glycogen synthase kinase-3 Cluster-8309.32494 BP_3 495.00 9.66 2761 91083595 XP_968896.1 1885 4.7e-208 PREDICTED: autophagy-related protein 9A [Tribolium castaneum]>gi|270006840|gb|EFA03288.1| hypothetical protein TcasGA2_TC013228 [Tribolium castaneum] 642924119 XM_963803.2 67 7.10144e-24 PREDICTED: Tribolium castaneum autophagy-related protein 9A (LOC657338), mRNA K17907 ATG9 autophagy-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K17907 Q3T904 1464 1.3e-160 Autophagy-related protein 9A OS=Bos taurus GN=ATG9A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2173 Integral membrane protein Cluster-8309.32495 BP_3 63.00 17.59 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32496 BP_3 200.23 7.19 1634 642915402 XP_008190599.1 1563 6.1e-171 PREDICTED: nocturnin isoform X1 [Tribolium castaneum] -- -- -- -- -- K18764 CCRN4L nocturnin http://www.genome.jp/dbget-bin/www_bget?ko:K18764 Q9UK39 750 4.7e-78 Nocturnin OS=Homo sapiens GN=CCRN4L PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.32498 BP_3 1739.93 73.29 1436 91081785 XP_973657.1 1265 1.9e-136 PREDICTED: putative E3 ubiquitin-protein ligase UBR7 [Tribolium castaneum]>gi|270005043|gb|EFA01491.1| hypothetical protein TcasGA2_TC007045 [Tribolium castaneum] -- -- -- -- -- K11979 UBR7 E3 ubiquitin-protein ligase UBR7 http://www.genome.jp/dbget-bin/www_bget?ko:K11979 Q8BU04 682 3.2e-70 Putative E3 ubiquitin-protein ligase UBR7 OS=Mus musculus GN=Ubr7 PE=1 SV=1 PF02207//PF00628 Putative zinc finger in N-recognin (UBR box)//PHD-finger GO:0016567 protein ubiquitination GO:0008270//GO:0005515//GO:0046872//GO:0004842 zinc ion binding//protein binding//metal ion binding//ubiquitin-protein transferase activity -- -- KOG2752 Uncharacterized conserved protein, contains N-recognin-type Zn-finger Cluster-8309.32499 BP_3 7.64 0.35 1333 642925292 XP_001814214.2 352 1.3e-30 PREDICTED: uncharacterized protein LOC100142468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32500 BP_3 81.83 1.99 2277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32502 BP_3 887.06 81.55 816 642937737 XP_008198926.1 722 1.0e-73 PREDICTED: tropomyosin-1, isoforms 9A/A/B isoform X19 [Tribolium castaneum] 780660612 XM_011694428.1 172 8.71527e-83 PREDICTED: Wasmannia auropunctata tropomyosin (LOC105452880), transcript variant X18, mRNA K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 P06754 566 5.1e-57 Tropomyosin-1, isoforms 9A/A/B OS=Drosophila melanogaster GN=Tm1 PE=2 SV=2 PF06009//PF02185//PF14073//PF02601//PF16716//PF00769//PF10186 Laminin Domain II//Hr1 repeat//Centrosome localisation domain of Cep57//Exonuclease VII, large subunit//Bone marrow stromal antigen 2//Ezrin/radixin/moesin family//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006308//GO:0010508//GO:0007155//GO:0051607//GO:0007165 DNA catabolic process//positive regulation of autophagy//cell adhesion//defense response to virus//signal transduction GO:0043015//GO:0008855//GO:0008092//GO:0042802 gamma-tubulin binding//exodeoxyribonuclease VII activity//cytoskeletal protein binding//identical protein binding GO:0005737//GO:0009318//GO:0045298//GO:0019898 cytoplasm//exodeoxyribonuclease VII complex//tubulin complex//extrinsic component of membrane KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.32503 BP_3 2697.62 46.87 3066 642932293 XP_008197052.1 806 6.9e-83 PREDICTED: epidermal growth factor-like protein 8 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9Y5W5 249 1.1e-19 Wnt inhibitory factor 1 OS=Homo sapiens GN=WIF1 PE=1 SV=3 PF11698//PF05531//PF16326//PF07645//PF00008 V-ATPase subunit H//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//Calcium-binding EGF domain//EGF-like domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005515//GO:0005509//GO:0003677 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//calcium ion binding//DNA binding GO:0000221//GO:0019028 vacuolar proton-transporting V-type ATPase, V1 domain//viral capsid KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.32505 BP_3 520.11 5.21 5107 270004497 EFA00945.1 2146 4.8e-238 hypothetical protein TcasGA2_TC003854 [Tribolium castaneum] -- -- -- -- -- K14416 HBS1 elongation factor 1 alpha-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K14416 Q69ZS7 1399 8.2e-153 HBS1-like protein OS=Mus musculus GN=Hbs1l PE=1 SV=2 PF01926//PF05773//PF03144//PF13495 50S ribosome-binding GTPase//RWD domain//Elongation factor Tu domain 2//Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677//GO:0005525//GO:0005515 DNA binding//GTP binding//protein binding -- -- KOG0458 Elongation factor 1 alpha Cluster-8309.32506 BP_3 42.07 0.82 2769 91088613 XP_973949.1 1122 1.4e-119 PREDICTED: pseudouridylate synthase 7 homolog [Tribolium castaneum]>gi|270011693|gb|EFA08141.1| hypothetical protein TcasGA2_TC005758 [Tribolium castaneum] -- -- -- -- -- K06176 truD, PUS7 tRNA pseudouridine13 synthase http://www.genome.jp/dbget-bin/www_bget?ko:K06176 Q96PZ0 568 1.0e-56 Pseudouridylate synthase 7 homolog OS=Homo sapiens GN=PUS7 PE=1 SV=2 PF01142//PF01353 tRNA pseudouridine synthase D (TruD)//Green fluorescent protein GO:0008218//GO:0001522//GO:0009451 bioluminescence//pseudouridine synthesis//RNA modification GO:0009982//GO:0003723 pseudouridine synthase activity//RNA binding -- -- KOG2339 Uncharacterized conserved protein Cluster-8309.32507 BP_3 213.10 4.36 2646 91088147 XP_971356.1 1186 5.1e-127 PREDICTED: platelet-activating factor acetylhydrolase [Tribolium castaneum]>gi|270012120|gb|EFA08568.1| hypothetical protein TcasGA2_TC006223 [Tribolium castaneum] -- -- -- -- -- K05961 dnk deoxynucleoside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05961 P70683 536 5.0e-53 Platelet-activating factor acetylhydrolase OS=Cavia porcellus GN=PLA2G7 PE=2 SV=1 PF03403//PF00005//PF01121//PF02367 Platelet-activating factor acetylhydrolase, isoform II//ABC transporter//Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0016042//GO:0002949//GO:0046486//GO:0015937//GO:0015940 lipid catabolic process//tRNA threonylcarbamoyladenosine modification//glycerolipid metabolic process//coenzyme A biosynthetic process//pantothenate biosynthetic process GO:0016887//GO:0004140//GO:0003847//GO:0005524 ATPase activity//dephospho-CoA kinase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//ATP binding GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4235 Mitochondrial thymidine kinase 2/deoxyguanosine kinase Cluster-8309.32508 BP_3 81.07 2.43 1902 270010983 EFA07431.1 1357 5.5e-147 cactin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUQ7 873 3.0e-92 Cactin OS=Homo sapiens GN=CACTIN PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2370 Cactin Cluster-8309.32511 BP_3 1211.76 110.98 818 478253481 ENN73808.1 879 6.3e-92 hypothetical protein YQE_09586, partial [Dendroctonus ponderosae]>gi|546679135|gb|ERL89640.1| hypothetical protein D910_07005 [Dendroctonus ponderosae] -- -- -- -- -- K13280 SEC11, sipW signal peptidase, endoplasmic reticulum-type http://www.genome.jp/dbget-bin/www_bget?ko:K13280 Q5R9C7 750 2.4e-78 Signal peptidase complex catalytic subunit SEC11A OS=Pongo abelii GN=SEC11A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3342 Signal peptidase I Cluster-8309.32512 BP_3 1246.24 10.46 6033 91093431 XP_969079.1 1185 1.5e-126 PREDICTED: AMMECR1-like protein [Tribolium castaneum]>gi|270015455|gb|EFA11903.1| hypothetical protein TcasGA2_TC004060 [Tribolium castaneum] 880861289 XM_005065312.2 74 2.00741e-27 PREDICTED: Mesocricetus auratus AMMECR1-like (Ammecr1l), transcript variant X3, mRNA -- -- -- -- Q5RAS7 774 2.9e-80 AMME syndrome candidate gene 1 protein homolog OS=Pongo abelii GN=AMMECR1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3274 Uncharacterized conserved protein, AMMECR1 Cluster-8309.32514 BP_3 52.78 1.48 2005 91083463 XP_971028.1 494 6.8e-47 PREDICTED: peptidyl-prolyl cis-trans isomerase B [Tribolium castaneum]>gi|270010823|gb|EFA07271.1| hypothetical protein TcasGA2_TC014505 [Tribolium castaneum] 698383907 XM_009815040.1 65 6.64318e-23 PREDICTED: Gavia stellata peptidylprolyl isomerase C (cyclophilin C) (PPIC), mRNA K03768 PPIB, ppiB peptidyl-prolyl cis-trans isomerase B (cyclophilin B) http://www.genome.jp/dbget-bin/www_bget?ko:K03768 P24367 436 1.5e-41 Peptidyl-prolyl cis-trans isomerase B OS=Gallus gallus GN=PPIB PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0880 Peptidyl-prolyl cis-trans isomerase Cluster-8309.32516 BP_3 467.64 23.40 1255 820836809 XP_012347035.1 266 1.2e-20 PREDICTED: multiple coagulation factor deficiency protein 2 homolog [Apis florea] 820836808 XM_012491581.1 84 1.12779e-33 PREDICTED: Apis florea multiple coagulation factor deficiency protein 2 homolog (LOC100872590), mRNA -- -- -- -- Q8NI22 133 1.3e-06 Multiple coagulation factor deficiency protein 2 OS=Homo sapiens GN=MCFD2 PE=1 SV=1 PF03133//PF13405//PF00036//PF13499 Tubulin-tyrosine ligase family//EF-hand domain//EF hand//EF-hand domain pair GO:0006464 cellular protein modification process GO:0005509 calcium ion binding -- -- KOG4065 Uncharacterized conserved protein Cluster-8309.32519 BP_3 853.33 23.33 2055 91089555 XP_971709.1 365 6.3e-32 PREDICTED: uncharacterized protein LOC660380 [Tribolium castaneum]>gi|270011380|gb|EFA07828.1| hypothetical protein TcasGA2_TC005397 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32520 BP_3 140.49 4.10 1945 91083175 XP_972331.1 975 1.1e-102 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 633 2.1e-64 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 PF15182 Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.32521 BP_3 437.45 3.12 7043 91087491 XP_968373.1 1498 9.1e-163 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] 462366872 APGK01027093.1 51 1.43108e-14 Dendroctonus ponderosae Seq01027103, whole genome shotgun sequence K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 P42765 1147 1.9e-123 3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens GN=ACAA2 PE=1 SV=2 PF02803//PF00108//PF05699 Thiolase, C-terminal domain//Thiolase, N-terminal domain//hAT family C-terminal dimerisation region GO:0008152 metabolic process GO:0016747//GO:0046983 transferase activity, transferring acyl groups other than amino-acyl groups//protein dimerization activity -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.32522 BP_3 785.08 18.34 2355 642916843 XP_008199526.1 1297 6.1e-140 PREDICTED: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [Tribolium castaneum]>gi|270003073|gb|EEZ99520.1| hypothetical protein TcasGA2_TC000101 [Tribolium castaneum] 642916842 XM_008201304.1 269 3.09331e-136 PREDICTED: Tribolium castaneum N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (LOC656887), mRNA K01482 DDAH, ddaH dimethylargininase http://www.genome.jp/dbget-bin/www_bget?ko:K01482 O94760 569 6.6e-57 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Homo sapiens GN=DDAH1 PE=1 SV=3 PF03808 Glycosyl transferase WecB/TagA/CpsF family GO:0006807//GO:0009058 nitrogen compound metabolic process//biosynthetic process GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0005737 cytoplasm -- -- Cluster-8309.32523 BP_3 54.70 0.72 3957 642914519 XP_008201711.1 844 3.5e-87 PREDICTED: post-GPI attachment to proteins factor 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWK6 535 9.7e-53 Post-GPI attachment to proteins factor 2-like OS=Drosophila melanogaster GN=CG7990 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG3979 FGF receptor activating protein 1 Cluster-8309.32525 BP_3 90.00 48.89 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32526 BP_3 693.66 92.03 655 478251510 ENN71973.1 414 4.2e-38 hypothetical protein YQE_11406, partial [Dendroctonus ponderosae]>gi|546670932|gb|ERL83482.1| hypothetical protein D910_00493 [Dendroctonus ponderosae]>gi|546672184|gb|ERL84166.1| hypothetical protein D910_01539 [Dendroctonus ponderosae]>gi|546673231|gb|ERL84880.1| hypothetical protein D910_02303 [Dendroctonus ponderosae]>gi|546679973|gb|ERL90339.1| hypothetical protein D910_07688 [Dendroctonus ponderosae] -- -- -- -- -- K04078 groES, HSPE1 chaperonin GroES http://www.genome.jp/dbget-bin/www_bget?ko:K04078 Q5DC69 321 1.0e-28 10 kDa heat shock protein, mitochondrial OS=Schistosoma japonicum GN=SJCHGC01960 PE=3 SV=2 PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm KOG1641 Mitochondrial chaperonin Cluster-8309.32530 BP_3 33.00 0.97 1929 557765835 XP_005182615.1 1540 3.3e-168 PREDICTED: fructose-bisphosphate aldolase isoform X2 [Musca domestica]>gi|755904857|ref|XP_011295962.1| PREDICTED: fructose-bisphosphate aldolase isoform X2 [Musca domestica] 659114129 KJ686589.1 557 0 Fenneropenaeus chinensis fructose 1,6-biphosphate-aldolase A mRNA, complete cds K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P05065 1259 5.3e-137 Fructose-bisphosphate aldolase A OS=Rattus norvegicus GN=Aldoa PE=1 SV=2 PF01545//PF00274 Cation efflux family//Fructose-bisphosphate aldolase class-I GO:0006020//GO:0006096//GO:0006098//GO:0055085//GO:0006013//GO:0006000//GO:0006812//GO:0006094//GO:0015976 inositol metabolic process//glycolytic process//pentose-phosphate shunt//transmembrane transport//mannose metabolic process//fructose metabolic process//cation transport//gluconeogenesis//carbon utilization GO:0004332//GO:0008324 fructose-bisphosphate aldolase activity//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1557 Fructose-biphosphate aldolase Cluster-8309.32531 BP_3 631.06 3.74 8425 820805550 AKG92766.1 2666 4.0e-298 Mlx interactor [Leptinotarsa decemlineata] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9HAP2 562 1.5e-55 MLX-interacting protein OS=Homo sapiens GN=MLXIP PE=1 SV=2 PF13180//PF00595//PF00010//PF06005 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Helix-loop-helix DNA-binding domain//Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly GO:0046983//GO:0005515 protein dimerization activity//protein binding GO:0005737 cytoplasm KOG3582 Mlx interactors and related transcription factors Cluster-8309.32534 BP_3 604.60 83.19 642 646705170 KDR13037.1 288 1.7e-23 hypothetical protein L798_13305 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W3T5 273 3.8e-23 Small integral membrane protein 4 OS=Drosophila melanogaster GN=CG32736 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32535 BP_3 177.41 1.22 7329 91094517 XP_971992.1 691 3.6e-69 PREDICTED: protein TEX261 isoform X2 [Tribolium castaneum] 665817572 XM_008559342.1 66 6.83262e-23 PREDICTED: Microplitis demolitor iron-sulfur cluster assembly 1 homolog, mitochondrial (LOC103578320), partial mRNA K13628 iscA, ISCA1 iron-sulfur cluster assembly protein http://www.genome.jp/dbget-bin/www_bget?ko:K13628 Q4QRC6 514 4.9e-50 Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Danio rerio GN=isca1 PE=2 SV=1 PF07882//PF12317 L-fucose isomerase, second N-terminal domain//Intraflagellar transport complex B protein 46 C terminal GO:0006004//GO:0006000//GO:0042073//GO:0006013 fucose metabolic process//fructose metabolic process//intraciliary transport//mannose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm KOG1120 Fe-S cluster biosynthesis protein ISA1 (contains a HesB-like domain) Cluster-8309.32538 BP_3 3727.67 65.26 3045 189236779 XP_967166.2 953 6.2e-100 PREDICTED: reticulon-1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 482 1.0e-46 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF01442//PF00834 Apolipoprotein A1/A4/E domain//Ribulose-phosphate 3 epimerase family GO:0006869//GO:0005975//GO:0042157 lipid transport//carbohydrate metabolic process//lipoprotein metabolic process GO:0008289//GO:0016857 lipid binding//racemase and epimerase activity, acting on carbohydrates and derivatives GO:0005576 extracellular region KOG1792 Reticulon Cluster-8309.32539 BP_3 290.00 6.53 2432 546683583 ERL93378.1 1257 2.8e-135 hypothetical protein D910_10670 [Dendroctonus ponderosae] 631238985 XM_007916224.1 78 4.79643e-30 Togninia minima UCRPA7 putative casein kinase ii subunit alpha protein mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 P21868 991 7.9e-106 Casein kinase II subunit alpha OS=Gallus gallus GN=CSNK2A1 PE=2 SV=1 PF00075//PF06293//PF00069//PF07714 RNase H//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0051252//GO:0006468 regulation of RNA metabolic process//protein phosphorylation GO:0004523//GO:0004672//GO:0016773//GO:0003676//GO:0005524 RNA-DNA hybrid ribonuclease activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//nucleic acid binding//ATP binding GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.3254 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32541 BP_3 168.10 5.57 1747 642930226 XP_008196308.1 1679 2.3e-184 PREDICTED: threo-3-hydroxyaspartate ammonia-lyase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01754 E4.3.1.19, ilvA, tdcB threonine dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01754 Q74FW6 606 2.5e-61 L-threonine ammonia-lyase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=tdcB PE=1 SV=1 PF01842 ACT domain GO:0008152 metabolic process GO:0016597 amino acid binding -- -- KOG1250 Threonine/serine dehydratases Cluster-8309.32542 BP_3 1256.00 62.20 1265 91085651 XP_970979.1 693 3.6e-70 PREDICTED: ER membrane protein complex subunit 7 homolog [Tribolium castaneum]>gi|270010092|gb|EFA06540.1| hypothetical protein TcasGA2_TC009444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R5V2 373 1.9e-34 ER membrane protein complex subunit 7 OS=Macaca fascicularis GN=EMC7 PE=2 SV=1 PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region KOG3306 Predicted membrane protein Cluster-8309.32543 BP_3 113.38 2.19 2784 478256531 ENN76715.1 706 2.5e-71 hypothetical protein YQE_06780, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R8X1 405 8.1e-38 Zinc finger protein 665 OS=Pongo abelii GN=ZNF665 PE=2 SV=1 PF16622//PF13912//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.32548 BP_3 15.76 0.54 1693 642928387 XP_008192723.1 425 5.8e-39 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00658 DLST, sucB 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) http://www.genome.jp/dbget-bin/www_bget?ko:K00658 P36957 267 5.0e-22 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens GN=DLST PE=1 SV=4 PF01213//PF07831 Adenylate cyclase associated (CAP) N terminal//Pyrimidine nucleoside phosphorylase C-terminal domain GO:0007010//GO:0006213 cytoskeleton organization//pyrimidine nucleoside metabolic process GO:0016763//GO:0003779 transferase activity, transferring pentosyl groups//actin binding -- -- KOG0559 Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) Cluster-8309.32550 BP_3 109.36 4.01 1606 91079260 XP_971902.1 1542 1.6e-168 PREDICTED: N-acetylgalactosamine kinase [Tribolium castaneum]>gi|270004305|gb|EFA00753.1| hypothetical protein TcasGA2_TC003637 [Tribolium castaneum] -- -- -- -- -- K18674 GALK2 N-acetylgalactosamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K18674 Q68FH4 976 2.9e-104 N-acetylgalactosamine kinase OS=Mus musculus GN=Galk2 PE=1 SV=1 PF00288 GHMP kinases N terminal domain GO:0046835//GO:0006012 carbohydrate phosphorylation//galactose metabolic process GO:0005524//GO:0004335 ATP binding//galactokinase activity GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.32551 BP_3 62.48 1.63 2137 642918890 XP_973456.3 989 2.9e-104 PREDICTED: persulfide dioxygenase ETHE1, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17725 ETHE1 sulfur dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K17725 Q9DCM0 746 1.8e-77 Persulfide dioxygenase ETHE1, mitochondrial OS=Mus musculus GN=Ethe1 PE=1 SV=2 PF15221 Lens epithelial cell protein LEP503 GO:0007275 multicellular organismal development -- -- -- -- KOG0813 Glyoxylase Cluster-8309.32552 BP_3 1866.35 106.17 1139 642922873 XP_008200433.1 1743 5.7e-192 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [Tribolium castaneum]>gi|270006562|gb|EFA03010.1| hypothetical protein TcasGA2_TC010433 [Tribolium castaneum] 195346084 XM_002039563.1 309 8.56162e-159 Drosophila sechellia GM22642 (Dsec\GM22642), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q5RCE2 1485 1.9e-163 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Pongo abelii GN=STT3A PE=2 SV=1 PF10034//PF02516 Q-cell neuroblast polarisation//Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0016021//GO:0016020//GO:0008250 integral component of membrane//membrane//oligosaccharyltransferase complex KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.32553 BP_3 1133.73 33.07 1944 478251087 ENN71563.1 634 3.8e-63 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 1.4e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF08465//PF07685 Thymidine kinase from Herpesvirus C-terminal//CobB/CobQ-like glutamine amidotransferase domain GO:0006230//GO:0006206//GO:0009236 TMP biosynthetic process//pyrimidine nucleobase metabolic process//cobalamin biosynthetic process GO:0004797//GO:0003824//GO:0005524 thymidine kinase activity//catalytic activity//ATP binding -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.32557 BP_3 845.58 34.89 1460 642922684 XP_008193279.1 482 1.2e-45 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X11 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 224 4.1e-17 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF10717//PF00057 Occlusion-derived virus envelope protein ODV-E18//Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.32559 BP_3 83.82 1.77 2574 642918045 XP_008198993.1 330 9.1e-28 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5PK40 259 6.4e-21 Choline transporter-like protein 3 OS=Bos taurus GN=SLC44A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.32564 BP_3 50.11 1.14 2405 478253016 ENN73396.1 2434 9.0e-272 hypothetical protein YQE_09958, partial [Dendroctonus ponderosae] 346709294 AK382373.1 419 0 Bombyx mori mRNA, clone: fdpe16B03 K11968 ARIH1 ariadne-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11968 Q94981 1973 1.1e-219 Protein ariadne-1 OS=Drosophila melanogaster GN=ari-1 PE=1 SV=2 PF14634//PF17123//PF00097//PF13639 zinc-RING finger domain//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.32565 BP_3 337.89 7.57 2444 478253016 ENN73396.1 2434 9.2e-272 hypothetical protein YQE_09958, partial [Dendroctonus ponderosae] 346709294 AK382373.1 419 0 Bombyx mori mRNA, clone: fdpe16B03 K11968 ARIH1 ariadne-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11968 Q94981 1973 1.1e-219 Protein ariadne-1 OS=Drosophila melanogaster GN=ari-1 PE=1 SV=2 PF00097//PF17123//PF14634//PF13639 Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//zinc-RING finger domain//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.32566 BP_3 116.42 2.40 2625 332376294 AEE63287.1 1800 3.2e-198 unknown [Dendroctonus ponderosae]>gi|478257770|gb|ENN77913.1| hypothetical protein YQE_05590, partial [Dendroctonus ponderosae] 642933156 XM_968826.3 47 8.85839e-13 PREDICTED: Tribolium castaneum trehalase (LOC662746), transcript variant X2, mRNA K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1648 5.6e-182 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.32568 BP_3 20.97 0.33 3319 91081621 XP_966892.1 951 1.1e-99 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P31684 456 1.2e-43 4-coumarate--CoA ligase 1 OS=Solanum tuberosum GN=4CL1 PE=3 SV=1 PF15151//PF03144//PF00501 Response gene to complement 32 protein family//Elongation factor Tu domain 2//AMP-binding enzyme GO:0051726//GO:0008152 regulation of cell cycle//metabolic process GO:0003824//GO:0005525 catalytic activity//GTP binding -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.32569 BP_3 1468.08 15.45 4871 91094409 XP_967943.1 1484 2.6e-161 PREDICTED: acyl-CoA Delta(11) desaturase [Tribolium castaneum]>gi|270016351|gb|EFA12797.1| hypothetical protein TcasGA2_TC014819 [Tribolium castaneum]>gi|576636744|gb|AHH30814.1| fatty acid desaturase D7 [Tribolium castaneum] 817052910 XM_012403667.1 98 7.37176e-41 PREDICTED: Athalia rosae acyl-CoA Delta(11) desaturase (LOC105687776), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 902 3.3e-95 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 PF00487//PF00096 Fatty acid desaturase//Zinc finger, C2H2 type GO:0006633//GO:0006629//GO:0055114 fatty acid biosynthetic process//lipid metabolic process//oxidation-reduction process GO:0046872//GO:0016717 metal ion binding//oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0016021 integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.32570 BP_3 296.00 10.12 1701 91088695 XP_975014.1 1682 1.0e-184 PREDICTED: pre-mRNA-splicing factor RBM22 [Tribolium castaneum]>gi|270012288|gb|EFA08736.1| hypothetical protein TcasGA2_TC006411 [Tribolium castaneum] 768442180 XM_011564550.1 131 1.14918e-59 PREDICTED: Plutella xylostella pre-mRNA-splicing factor RBM22 (LOC105392866), mRNA K12872 RBM22, SLT11 pre-mRNA-splicing factor RBM22/SLT11 http://www.genome.jp/dbget-bin/www_bget?ko:K12872 Q8BHS3 1371 4.8e-150 Pre-mRNA-splicing factor RBM22 OS=Mus musculus GN=Rbm22 PE=1 SV=1 PF00076//PF08777//PF01363//PF00642 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif//FYVE zinc finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0003723//GO:0008270//GO:0000166//GO:0003676 metal ion binding//RNA binding//zinc ion binding//nucleotide binding//nucleic acid binding -- -- KOG0153 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.32571 BP_3 3384.35 193.90 1133 546683906 ERL93654.1 312 4.9e-26 hypothetical protein D910_10942 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32572 BP_3 68.35 2.34 1702 642929992 XP_975639.2 782 2.3e-80 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QQM4 345 4.5e-31 Zinc finger protein 474 OS=Bos taurus GN=ZNF474 PE=2 SV=1 PF13465//PF00096//PF08782 Zinc-finger double domain//Zinc finger, C2H2 type//c-SKI Smad4 binding domain -- -- GO:0046872//GO:0046332 metal ion binding//SMAD binding -- -- -- -- Cluster-8309.32573 BP_3 17.00 1.75 761 345452847 AEN94575.1 803 3.8e-83 cyclophilin A [Scylla paramamosain]>gi|402536590|gb|AFQ62796.1| cyclophilin A [Scylla paramamosain] 345452846 HQ260921.1 757 0 Scylla paramamosain cyclophilin A mRNA, complete cds K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 P25007 648 1.5e-66 Peptidyl-prolyl cis-trans isomerase OS=Drosophila melanogaster GN=Cyp1 PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.32574 BP_3 12.35 0.67 1175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32576 BP_3 76.17 1.00 3958 642916252 XP_008190947.1 2331 1.3e-259 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 86 2.80185e-34 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 582 3.4e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF13499//PF14604//PF00018//PF00036//PF13405//PF12763 EF-hand domain pair//Variant SH3 domain//SH3 domain//EF hand//EF-hand domain//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.32577 BP_3 6.00 0.51 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32579 BP_3 39.43 4.58 707 642919747 XP_008192048.1 232 5.7e-17 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32581 BP_3 13.00 1.32 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32582 BP_3 74.51 3.21 1411 270005904 EFA02352.1 233 8.8e-17 hypothetical protein TcasGA2_TC008022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32584 BP_3 100.00 18.16 557 91085371 XP_971695.1 382 1.8e-34 PREDICTED: mitochondrial import inner membrane translocase subunit TIM16 [Tribolium castaneum]>gi|270009135|gb|EFA05583.1| hypothetical protein TcasGA2_TC015786 [Tribolium castaneum] -- -- -- -- -- K17805 PAM16, TIM16 mitochondrial import inner membrane translocase subunit TIM16 http://www.genome.jp/dbget-bin/www_bget?ko:K17805 Q6PBL0 276 1.5e-23 Mitochondrial import inner membrane translocase subunit tim16 OS=Danio rerio GN=pam16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3442 Uncharacterized conserved protein Cluster-8309.32585 BP_3 38.84 1.03 2110 642933468 XP_973513.2 1908 7.8e-211 PREDICTED: homogentisate 1,2-dioxygenase [Tribolium castaneum] 687022014 LM523162.1 170 2.99054e-81 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000005 K00451 HGD, hmgA homogentisate 1,2-dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00451 O09173 1652 1.6e-182 Homogentisate 1,2-dioxygenase OS=Mus musculus GN=Hgd PE=1 SV=2 PF04209 homogentisate 1,2-dioxygenase GO:0006559//GO:0006570//GO:0055114//GO:0042207 L-phenylalanine catabolic process//tyrosine metabolic process//oxidation-reduction process//styrene catabolic process GO:0004411 homogentisate 1,2-dioxygenase activity -- -- KOG1417 Homogentisate 1,2-dioxygenase Cluster-8309.32586 BP_3 23.00 0.90 1521 795010007 XP_011864749.1 696 1.9e-70 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32588 BP_3 98.73 6.32 1045 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32591 BP_3 270.23 3.64 3873 642916252 XP_008190947.1 2337 2.6e-260 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 94 9.78936e-39 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 580 5.8e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF00036//PF13405//PF13499//PF14604//PF00018//PF12763 EF hand//EF-hand domain//EF-hand domain pair//Variant SH3 domain//SH3 domain//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.32593 BP_3 228.98 2.36 4968 270004168 EFA00616.1 1791 6.8e-197 hypothetical protein TcasGA2_TC003491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15811 853 1.6e-89 Intersectin-1 OS=Homo sapiens GN=ITSN1 PE=1 SV=3 PF13181//PF00168//PF00621 Tetratricopeptide repeat//C2 domain//RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.32597 BP_3 64.00 6.69 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32601 BP_3 219.49 1.56 7089 642915712 XP_008190771.1 2157 3.5e-239 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 2.3e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF02454//PF00621 Sigma 1s protein//RhoGEF domain GO:0043087//GO:0035023//GO:0019048 regulation of GTPase activity//regulation of Rho protein signal transduction//modulation by virus of host morphology or physiology GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.32602 BP_3 208.03 7.26 1672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32604 BP_3 699.12 15.77 2429 91076548 XP_966358.1 499 2.2e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.6e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF11095//PF07716//PF00010//PF05093 Gem-associated protein 7 (Gemin7)//Basic region leucine zipper//Helix-loop-helix DNA-binding domain//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0006355//GO:0016226 regulation of transcription, DNA-templated//iron-sulfur cluster assembly GO:0003700//GO:0043565//GO:0051536//GO:0046983 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//iron-sulfur cluster binding//protein dimerization activity GO:0032797//GO:0005737//GO:0005667 SMN complex//cytoplasm//transcription factor complex KOG4020 Protein DRE2, required for cell viability Cluster-8309.32605 BP_3 82.09 0.69 6014 642919377 XP_008191846.1 1787 2.4e-196 PREDICTED: vascular endothelial growth factor receptor 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P35969 400 6.7e-37 Vascular endothelial growth factor receptor 1 OS=Mus musculus GN=Flt1 PE=1 SV=1 PF00069//PF07714//PF02480//PF13895//PF01325 Protein kinase domain//Protein tyrosine kinase//Alphaherpesvirus glycoprotein E//Immunoglobulin domain//Iron dependent repressor, N-terminal DNA binding domain GO:0006468 protein phosphorylation GO:0005524//GO:0003677//GO:0005515//GO:0004672 ATP binding//DNA binding//protein binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.32606 BP_3 187.08 2.77 3545 642923805 XP_008193890.1 1839 1.3e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 6.9e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0003723//GO:0000166 nucleic acid binding//RNA binding//nucleotide binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.32607 BP_3 219.69 1.98 5631 91092490 XP_968084.1 602 5.7e-59 PREDICTED: protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [Tribolium castaneum]>gi|270012934|gb|EFA09382.1| hypothetical protein TcasGA2_TC001944 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMR3 558 3.0e-55 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Gallus gallus GN=PCMTD1 PE=2 SV=1 PF07664//PF07525//PF08704//PF01135//PF08123 Ferrous iron transport protein B C terminus//SOCS box//tRNA methyltransferase complex GCD14 subunit//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Histone methylation protein DOT1 GO:0030488//GO:0006464//GO:0006554//GO:0015684//GO:0008033//GO:0046500//GO:0035556//GO:0006479//GO:0009451 tRNA methylation//cellular protein modification process//lysine catabolic process//ferrous iron transport//tRNA processing//S-adenosylmethionine metabolic process//intracellular signal transduction//protein methylation//RNA modification GO:0016429//GO:0018024//GO:0015093//GO:0004719 tRNA (adenine-N1-)-methyltransferase activity//histone-lysine N-methyltransferase activity//ferrous iron transmembrane transporter activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0016021//GO:0031515 integral component of membrane//tRNA (m1A) methyltransferase complex KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.32608 BP_3 11.54 0.51 1377 332376847 AEE63563.1 1353 1.2e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01555 FAH, fahA fumarylacetoacetase http://www.genome.jp/dbget-bin/www_bget?ko:K01555 A5PKH3 1077 4.8e-116 Fumarylacetoacetase OS=Bos taurus GN=FAH PE=2 SV=1 PF01557//PF09298 Fumarylacetoacetate (FAA) hydrolase family//Fumarylacetoacetase N-terminal GO:0009072//GO:0008152//GO:0006570//GO:0042207 aromatic amino acid family metabolic process//metabolic process//tyrosine metabolic process//styrene catabolic process GO:0003824//GO:0004334 catalytic activity//fumarylacetoacetase activity -- -- KOG2843 Fumarylacetoacetase Cluster-8309.32609 BP_3 77253.74 3505.32 1354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32610 BP_3 30.00 0.70 2356 815810143 XP_012225962.1 189 1.9e-11 PREDICTED: zinc finger protein 467-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q7KQZ4 162 1.0e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF06467//PF01155//PF02150//PF13465//PF00096 MYM-type Zinc finger with FCS sequence motif//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006206//GO:0006144//GO:0006351//GO:0006464 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//cellular protein modification process GO:0046872//GO:0008270//GO:0016151//GO:0003677//GO:0003899 metal ion binding//zinc ion binding//nickel cation binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.32613 BP_3 182.99 3.80 2614 642927700 XP_008196611.1 1675 1.0e-183 PREDICTED: LOW QUALITY PROTEIN: oxidative stress-induced growth inhibitor 2-like [Tribolium castaneum] 642927699 XM_008198389.1 99 1.09362e-41 PREDICTED: Tribolium castaneum oxidative stress-induced growth inhibitor 2-like (LOC655536), mRNA -- -- -- -- Q9UJX0 433 4.3e-41 Oxidative stress-induced growth inhibitor 1 OS=Homo sapiens GN=OSGIN1 PE=1 SV=3 PF07992//PF01494//PF00070 Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491//GO:0071949 oxidoreductase activity//FAD binding -- -- -- -- Cluster-8309.32614 BP_3 4098.36 106.76 2142 91085703 XP_972591.1 1384 4.6e-150 PREDICTED: uncharacterized protein LOC661334 isoform X2 [Tribolium castaneum]>gi|270010100|gb|EFA06548.1| hypothetical protein TcasGA2_TC009456 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11890 Domain of unknown function (DUF3410) -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.32615 BP_3 1830.01 26.04 3679 91087131 XP_975238.1 1903 5.2e-210 PREDICTED: trifunctional enzyme subunit beta, mitochondrial [Tribolium castaneum]>gi|270009593|gb|EFA06041.1| hypothetical protein TcasGA2_TC008872 [Tribolium castaneum] -- -- -- -- -- K07509 HADHB acetyl-CoA acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07509 O46629 1462 2.9e-160 Trifunctional enzyme subunit beta, mitochondrial OS=Bos taurus GN=HADHB PE=2 SV=1 PF08541//PF02803//PF08545//PF00108 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//Thiolase, C-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0008152//GO:0006633//GO:0008610 acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process//lipid biosynthetic process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1068 Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases Cluster-8309.32616 BP_3 1388.93 26.41 2827 478256813 ENN76988.1 1692 1.2e-185 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] 195439161 XM_002067464.1 61 1.57442e-20 Drosophila willistoni GK16160 (Dwil\GK16160), mRNA K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 Q9NFT7 1051 1.0e-112 Hexokinase type 2 OS=Drosophila melanogaster GN=Hex-t2 PE=2 SV=4 PF00349//PF03727 Hexokinase//Hexokinase GO:0005975 carbohydrate metabolic process GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG1369 Hexokinase Cluster-8309.32617 BP_3 70.05 0.66 5444 478256813 ENN76988.1 971 9.0e-102 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] 195439161 XM_002067464.1 46 6.65047e-12 Drosophila willistoni GK16160 (Dwil\GK16160), mRNA K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 Q9NFT7 577 1.8e-57 Hexokinase type 2 OS=Drosophila melanogaster GN=Hex-t2 PE=2 SV=4 PF03727//PF00349 Hexokinase//Hexokinase GO:0005975 carbohydrate metabolic process GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG1369 Hexokinase Cluster-8309.32618 BP_3 31.71 0.41 4042 478256813 ENN76988.1 226 1.6e-15 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] -- -- -- -- -- K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 -- -- -- -- PF00349 Hexokinase GO:0005975 carbohydrate metabolic process GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.32619 BP_3 177.29 2.18 4211 478256813 ENN76988.1 271 1.0e-20 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] -- -- -- -- -- K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 -- -- -- -- PF00349 Hexokinase GO:0005975 carbohydrate metabolic process GO:0016773//GO:0005524 phosphotransferase activity, alcohol group as acceptor//ATP binding -- -- -- -- Cluster-8309.3262 BP_3 1.00 0.52 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32620 BP_3 325.51 4.87 3516 91082907 XP_972373.1 1236 1.1e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.6e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF07224//PF00787//PF00326//PF10503//PF12740 Chlorophyllase//PX domain//Prolyl oligopeptidase family//Esterase PHB depolymerase//Chlorophyllase enzyme GO:0006508//GO:0015996//GO:0015947//GO:0046294//GO:0015994 proteolysis//chlorophyll catabolic process//methane metabolic process//formaldehyde catabolic process//chlorophyll metabolic process GO:0008236//GO:0018738//GO:0035091//GO:0047746 serine-type peptidase activity//S-formylglutathione hydrolase activity//phosphatidylinositol binding//chlorophyllase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.32621 BP_3 47.42 0.71 3518 91082907 XP_972373.1 1236 1.1e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.6e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF12740//PF10503//PF00326//PF00787//PF07224 Chlorophyllase enzyme//Esterase PHB depolymerase//Prolyl oligopeptidase family//PX domain//Chlorophyllase GO:0015947//GO:0015996//GO:0015994//GO:0046294//GO:0006508 methane metabolic process//chlorophyll catabolic process//chlorophyll metabolic process//formaldehyde catabolic process//proteolysis GO:0035091//GO:0047746//GO:0018738//GO:0008236 phosphatidylinositol binding//chlorophyllase activity//S-formylglutathione hydrolase activity//serine-type peptidase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.32622 BP_3 1574.19 66.72 1429 91090428 XP_971598.1 650 3.9e-65 PREDICTED: THO complex subunit 4 [Tribolium castaneum]>gi|270013379|gb|EFA09827.1| hypothetical protein TcasGA2_TC011974 [Tribolium castaneum] -- -- -- -- -- K12881 THOC4, ALY THO complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12881 Q58EA2 383 1.5e-35 THO complex subunit 4-A OS=Xenopus laevis GN=alyref-a PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.32623 BP_3 1005.64 20.14 2698 91080851 XP_971681.1 2083 5.1e-231 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005416|gb|EFA01864.1| hypothetical protein TcasGA2_TC007467 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 1203 2.3e-130 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF13304//PF01637//PF01061//PF03193//PF00005//PF00004 AAA domain, putative AbiEii toxin, Type IV TA system//Archaeal ATPase//ABC-2 type transporter//Protein of unknown function, DUF258//ABC transporter//ATPase family associated with various cellular activities (AAA) -- -- GO:0016887//GO:0005525//GO:0005524//GO:0000166//GO:0017111//GO:0003924 ATPase activity//GTP binding//ATP binding//nucleotide binding//nucleoside-triphosphatase activity//GTPase activity GO:0016020 membrane -- -- Cluster-8309.32625 BP_3 211.00 5.26 2226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32626 BP_3 30.22 4.90 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32627 BP_3 7.72 1.70 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32629 BP_3 457.36 13.24 1957 270004866 EFA01314.1 659 4.9e-66 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 484 3.9e-47 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 PF00034 Cytochrome c GO:0006118 obsolete electron transport GO:0020037//GO:0009055 heme binding//electron carrier activity -- -- -- -- Cluster-8309.32632 BP_3 247.41 5.43 2488 478256780 ENN76958.1 397 1.5e-35 hypothetical protein YQE_06526, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00727 Interleukin 4 GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0008083//GO:0005136 growth factor activity//interleukin-4 receptor binding GO:0005576//GO:0016516 extracellular region//interleukin-4 receptor complex -- -- Cluster-8309.32633 BP_3 1374.55 17.00 4189 91084825 XP_973466.1 1748 5.5e-192 PREDICTED: GAS2-like protein 2 [Tribolium castaneum]>gi|642925938|ref|XP_008194703.1| PREDICTED: GAS2-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZP9 712 3.1e-73 GAS2-like protein 1 OS=Mus musculus GN=Gas2l1 PE=2 SV=1 PF02187//PF00307 Growth-Arrest-Specific Protein 2 Domain//Calponin homology (CH) domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.32634 BP_3 26.61 0.98 1601 189235746 XP_967247.2 510 7.6e-49 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 307 1.1e-26 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137//PF08117 Adenosine-deaminase (editase) domain//Ptu family GO:0006810//GO:0006144//GO:0009405//GO:0006396//GO:0006807 transport//purine nucleobase metabolic process//pathogenesis//RNA processing//nitrogen compound metabolic process GO:0004000//GO:0003723//GO:0019855 adenosine deaminase activity//RNA binding//calcium channel inhibitor activity GO:0005576 extracellular region KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.32635 BP_3 690.84 7.34 4826 270006379 EFA02827.1 1550 5.8e-169 plenty of SH3s [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.0e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF17123//PF14634//PF00097//PF02891//PF09360//PF14604//PF00018//PF13639//PF16685 RING-like zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger//Iron-binding zinc finger CDGSH type//Variant SH3 domain//SH3 domain//Ring finger domain//zinc RING finger of MSL2 -- -- GO:0046872//GO:0005515//GO:0061630//GO:0051537//GO:0008270 metal ion binding//protein binding//ubiquitin protein ligase activity//2 iron, 2 sulfur cluster binding//zinc ion binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.32636 BP_3 247.00 11.40 1336 270007614 EFA04062.1 1060 1.1e-112 hypothetical protein TcasGA2_TC014295 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5HZI9 647 3.4e-66 Solute carrier family 25 member 51 OS=Mus musculus GN=Slc25a51 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1519 Predicted mitochondrial carrier protein Cluster-8309.32638 BP_3 139.15 0.77 9026 642923445 XP_008193747.1 789 1.9e-80 PREDICTED: COP9 signalosome complex subunit 8 [Tribolium castaneum]>gi|270008317|gb|EFA04765.1| hypothetical protein TcasGA2_TC030655 [Tribolium castaneum] -- -- -- -- -- K12181 COPS8, CSN8 COP9 signalosome complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12181 Q6GQA6 469 1.0e-44 COP9 signalosome complex subunit 8 OS=Xenopus laevis GN=csn8 PE=2 SV=2 PF04069//PF01399 Substrate binding domain of ABC-type glycine betaine transport system//PCI domain GO:0006810 transport GO:0005515//GO:0005215 protein binding//transporter activity -- -- -- -- Cluster-8309.32639 BP_3 1577.19 29.67 2854 642915300 XP_008190561.1 2869 0.0e+00 PREDICTED: JNK-interacting protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29EP6 1279 3.7e-139 JNK-interacting protein 3 OS=Drosophila pseudoobscura pseudoobscura GN=syd PE=3 SV=2 PF10186//PF04508//PF01763 Vacuolar sorting 38 and autophagy-related subunit 14//Viral A-type inclusion protein repeat//Herpesvirus UL6 like GO:0016032//GO:0006323//GO:0010508 viral process//DNA packaging//positive regulation of autophagy -- -- -- -- KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.3264 BP_3 5.00 0.44 836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32640 BP_3 89.49 5.14 1131 478251739 ENN72191.1 347 4.3e-30 hypothetical protein YQE_11151, partial [Dendroctonus ponderosae]>gi|546670640|gb|ERL83324.1| hypothetical protein D910_00219 [Dendroctonus ponderosae]>gi|546672556|gb|ERL84373.1| hypothetical protein D910_01801 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32642 BP_3 30.86 0.45 3565 189242201 XP_972508.2 346 1.8e-29 PREDICTED: protein suppressor of white apricot, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127//PF01805//PF04277 Late nodulin protein//Surp module//Oxaloacetate decarboxylase, gamma chain GO:0006525//GO:0006560//GO:0006814//GO:0071436//GO:0009878//GO:0006090//GO:0006396 arginine metabolic process//proline metabolic process//sodium ion transport//sodium ion export//nodule morphogenesis//pyruvate metabolic process//RNA processing GO:0003723//GO:0008948//GO:0015081//GO:0046872 RNA binding//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.32650 BP_3 140.27 1.04 6803 642914427 XP_008201492.1 5265 0.0e+00 PREDICTED: rootletin [Tribolium castaneum] 462381540 APGK01021978.1 59 4.93573e-19 Dendroctonus ponderosae Seq01021988, whole genome shotgun sequence K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 1416 1.2e-154 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF16331//PF10473//PF07851//PF16326//PF04111//PF07926 TolA binding protein trimerisation//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TMPIT-like protein//ABC transporter C-terminal domain//Autophagy protein Apg6//TPR/MLP1/MLP2-like protein GO:0070206//GO:0006914//GO:0006606 protein trimerization//autophagy//protein import into nucleus GO:0003677//GO:0045502//GO:0008134//GO:0042803 DNA binding//dynein binding//transcription factor binding//protein homodimerization activity GO:0030286//GO:0016021//GO:0005667 dynein complex//integral component of membrane//transcription factor complex -- -- Cluster-8309.32651 BP_3 425.56 9.28 2501 546682338 ERL92286.1 1156 1.5e-123 hypothetical protein D910_09603 [Dendroctonus ponderosae] -- -- -- -- -- K15728 LPIN phosphatidate phosphatase LPIN http://www.genome.jp/dbget-bin/www_bget?ko:K15728 Q99PI4 385 1.5e-35 Phosphatidate phosphatase LPIN3 OS=Mus musculus GN=Lpin3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2116 Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism Cluster-8309.32653 BP_3 16.85 1.44 854 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32654 BP_3 2.00 0.61 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32655 BP_3 456.97 8.18 2985 270006239 EFA02687.1 3258 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1457 9.0e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02020//PF02854//PF02180 eIF4-gamma/eIF5/eIF2-epsilon//MIF4G domain//Bcl-2 homology region 4 GO:0042981 regulation of apoptotic process GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.32656 BP_3 89.00 11.84 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32657 BP_3 439.92 8.40 2816 270006239 EFA02687.1 3258 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1457 8.5e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02854//PF02020 MIF4G domain//eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.32658 BP_3 198.65 3.47 3048 270006239 EFA02687.1 3303 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1459 5.4e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02854//PF02180//PF02020//PF00763 MIF4G domain//Bcl-2 homology region 4//eIF4-gamma/eIF5/eIF2-epsilon//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0046487//GO:0009396//GO:0055114//GO:0042981 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process//regulation of apoptotic process GO:0004488//GO:0005515//GO:0003723//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//protein binding//RNA binding//catalytic activity -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.32659 BP_3 6.00 3.44 373 734614522 XP_010734822.1 217 1.7e-15 PREDICTED: polyubiquitin-B isoform X6 [Larimichthys crocea] 462370374 APGK01025878.1 75 3.16732e-29 Dendroctonus ponderosae Seq01025888, whole genome shotgun sequence K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 212 2.6e-16 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.32660 BP_3 160.19 2.12 3933 642911078 XP_008200566.1 2414 3.1e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 3.5e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF00641//PF07808//PF01585//PF13442//PF11648 Zn-finger in Ran binding protein and others//RED-like protein N-terminal region//G-patch domain//Cytochrome C oxidase, cbb3-type, subunit III//C-terminal domain of RIG-I GO:0006118 obsolete electron transport GO:0008270//GO:0000166//GO:0009055//GO:0003676//GO:0020037//GO:0016817 zinc ion binding//nucleotide binding//electron carrier activity//nucleic acid binding//heme binding//hydrolase activity, acting on acid anhydrides GO:0005634//GO:0005622 nucleus//intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.32661 BP_3 36.41 0.40 4643 642911078 XP_008200566.1 2195 9.0e-244 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 686 3.5e-70 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF01080//PF07808//PF01585//PF00641//PF13442//PF00076//PF11648 Presenilin//RED-like protein N-terminal region//G-patch domain//Zn-finger in Ran binding protein and others//Cytochrome C oxidase, cbb3-type, subunit III//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C-terminal domain of RIG-I GO:0006118 obsolete electron transport GO:0003676//GO:1901363//GO:0008270//GO:0097159//GO:0009055//GO:0016817//GO:0020037//GO:0004190 nucleic acid binding//heterocyclic compound binding//zinc ion binding//organic cyclic compound binding//electron carrier activity//hydrolase activity, acting on acid anhydrides//heme binding//aspartic-type endopeptidase activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.32667 BP_3 78.08 4.00 1232 478256542 ENN76726.1 203 2.3e-13 hypothetical protein YQE_06791, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q52KB5 152 7.8e-09 Zinc finger and BTB domain-containing protein 24 OS=Danio rerio GN=zbtb24 PE=2 SV=1 PF16622//PF00096 zinc-finger C2H2-type//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.32670 BP_3 79.00 14.35 557 332373602 AEE61942.1 475 3.0e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm -- -- Cluster-8309.32672 BP_3 43.00 1.45 1723 642918391 XP_008200125.1 965 1.4e-101 PREDICTED: zinc finger protein 271-like [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q61116 507 7.5e-50 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF01155//PF13465//PF00096//PF04810//PF01584//PF13912 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-finger double domain//Zinc finger, C2H2 type//Sec23/Sec24 zinc finger//CheW-like domain//C2H2-type zinc finger GO:0006888//GO:0006886//GO:0006935//GO:0006464//GO:0007165 ER to Golgi vesicle-mediated transport//intracellular protein transport//chemotaxis//cellular protein modification process//signal transduction GO:0016151//GO:0046872//GO:0004871//GO:0008270 nickel cation binding//metal ion binding//signal transducer activity//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.32673 BP_3 63.50 1.69 2098 471396316 XP_004381787.1 595 1.4e-58 PREDICTED: zinc finger protein 615 isoform X1 [Trichechus manatus latirostris] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 554 3.2e-55 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF01197//PF13465//PF00096//PF16622//PF02350//PF13912 Ribosomal protein L31//Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//UDP-N-acetylglucosamine 2-epimerase//C2H2-type zinc finger GO:0006047//GO:0042254//GO:0006412 UDP-N-acetylglucosamine metabolic process//ribosome biogenesis//translation GO:0003735//GO:0046872 structural constituent of ribosome//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.32674 BP_3 11.00 0.59 1197 646717332 KDR20226.1 527 6.1e-51 hypothetical protein L798_05535, partial [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q4R4C7 461 1.1e-44 Zinc finger protein 14 OS=Macaca fascicularis GN=ZNF14 PE=2 SV=1 PF00096//PF13465//PF02892//PF13912//PF05191 Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0003677//GO:0046872//GO:0004017 DNA binding//metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.32675 BP_3 43.00 7.45 570 478256535 ENN76719.1 425 1.9e-39 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6QLU5 201 7.5e-15 Zinc finger protein 184 OS=Bos taurus GN=ZNF184 PE=2 SV=1 PF13465//PF00096//PF07535//PF01363//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//DBF zinc finger//FYVE zinc finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.32677 BP_3 1643.43 10.88 7570 478256535 ENN76719.1 1038 2.1e-109 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 683942502 XM_009101103.1 36 3.35441e-06 PREDICTED: Serinus canaria zinc finger protein 329-like (LOC103825865), partial mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 629 2.3e-63 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13465//PF12142//PF07975//PF04810//PF13912//PF01428//PF16622//PF05191//PF00096//PF00130//PF01155//PF06397//PF04889//PF07776 Zinc-finger double domain//Polyphenol oxidase middle domain//TFIIH C1-like domain//Sec23/Sec24 zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Desulfoferrodoxin, N-terminal domain//Cwf15/Cwc15 cell cycle control protein//Zinc-finger associated domain (zf-AD) GO:0006464//GO:0006570//GO:0006281//GO:0006886//GO:0046034//GO:0006118//GO:0000398//GO:0035556//GO:0055114//GO:0006888//GO:0006144 cellular protein modification process//tyrosine metabolic process//DNA repair//intracellular protein transport//ATP metabolic process//obsolete electron transport//mRNA splicing, via spliceosome//intracellular signal transduction//oxidation-reduction process//ER to Golgi vesicle-mediated transport//purine nucleobase metabolic process GO:0004097//GO:0008270//GO:0005506//GO:0004017//GO:0016151//GO:0046872 catechol oxidase activity//zinc ion binding//iron ion binding//adenylate kinase activity//nickel cation binding//metal ion binding GO:0030127//GO:0005634//GO:0005681 COPII vesicle coat//nucleus//spliceosomal complex -- -- Cluster-8309.32679 BP_3 10.00 0.34 1722 478256535 ENN76719.1 352 1.7e-30 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6PF04 308 8.9e-27 Zinc finger protein 613 OS=Homo sapiens GN=ZNF613 PE=2 SV=2 PF13465//PF16622//PF13912//PF01155//PF00830//PF00096//PF00518//PF02207 Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Ribosomal L28 family//Zinc finger, C2H2 type//Early Protein (E6)//Putative zinc finger in N-recognin (UBR box) GO:0006464//GO:0042254 cellular protein modification process//ribosome biogenesis GO:0016151//GO:0003677//GO:0046872//GO:0003735//GO:0008270 nickel cation binding//DNA binding//metal ion binding//structural constituent of ribosome//zinc ion binding GO:0042025//GO:0005840 host cell nucleus//ribosome -- -- Cluster-8309.32681 BP_3 74.99 1.96 2139 524894604 XP_005103798.1 196 2.6e-12 PREDICTED: zinc finger protein 431-like [Aplysia californica] -- -- -- -- -- -- -- -- -- Q08876 138 5.7e-07 Protein suppressor of hairy wing OS=Drosophila virilis GN=su(Hw) PE=2 SV=1 PF13912//PF02290//PF00096//PF13465 C2H2-type zinc finger//Signal recognition particle 14kD protein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0046872//GO:0008312//GO:0030942 metal ion binding//7S RNA binding//endoplasmic reticulum signal peptide binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting -- -- Cluster-8309.32682 BP_3 823.00 13.00 3344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32683 BP_3 1108.50 5.43 10127 478256535 ENN76719.1 1015 1.3e-106 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86WZ6 552 2.7e-54 Zinc finger protein 227 OS=Homo sapiens GN=ZNF227 PE=1 SV=1 PF07776//PF01256//PF00412//PF13912//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Carbohydrate kinase//LIM domain//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0052855//GO:0008270//GO:0046872 ADP-dependent NAD(P)H-hydrate dehydratase activity//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.32684 BP_3 6.94 0.46 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02262 CBL proto-oncogene N-terminal domain 1 GO:0007166//GO:0007165 cell surface receptor signaling pathway//signal transduction GO:0004871 signal transducer activity GO:0005634 nucleus -- -- Cluster-8309.32686 BP_3 2828.97 163.84 1124 189236533 XP_975493.2 1064 3.1e-113 PREDICTED: triosephosphate isomerase [Tribolium castaneum]>gi|270005300|gb|EFA01748.1| hypothetical protein TcasGA2_TC007346 [Tribolium castaneum] 440200132 JQ784063.1 57 1.02955e-18 Eriocraniella aurosparsella voucher Erau triosephosphate isomerase mRNA, partial cds K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P30741 972 5.9e-104 Triosephosphate isomerase OS=Culex tarsalis GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006094//GO:0015976//GO:0046486//GO:0006000//GO:0006013//GO:0008152//GO:0006096//GO:0006020 gluconeogenesis//carbon utilization//glycerolipid metabolic process//fructose metabolic process//mannose metabolic process//metabolic process//glycolytic process//inositol metabolic process GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.32687 BP_3 96.19 0.77 6313 642917185 XP_966369.3 1730 1.0e-189 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 944 5.8e-100 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF07651 ANTH domain -- -- GO:0005543 phospholipid binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.32689 BP_3 792.76 4.28 9229 642937658 XP_008198888.1 5159 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 14 [Tribolium castaneum] 157132702 XM_001662569.1 146 2.90667e-67 Aedes aegypti AAEL012490-RA partial mRNA K15156 MED14, RGR1 mediator of RNA polymerase II transcription subunit 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15156 Q16U49 3484 0.0e+00 Mediator of RNA polymerase II transcription subunit 14 OS=Aedes aegypti GN=MED14 PE=3 SV=2 PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1875 Thyroid hormone receptor-associated coactivator complex component (TRAP170) Cluster-8309.32690 BP_3 388.11 19.58 1247 189238165 XP_973195.2 697 1.2e-70 PREDICTED: serine protease gd-like [Tribolium castaneum]>gi|642925379|ref|XP_008194524.1| PREDICTED: serine protease gd-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 493 2.3e-48 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32692 BP_3 202.31 2.25 4626 642932474 XP_008197131.1 1119 5.3e-119 PREDICTED: uncharacterized protein LOC662025 isoform X1 [Tribolium castaneum] 642932473 XM_008198909.1 192 3.89651e-93 PREDICTED: Tribolium castaneum uncharacterized LOC662025 (LOC662025), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32694 BP_3 57.69 9.58 582 741829858 AJA91073.1 625 1.3e-62 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 500 1.6e-49 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.32697 BP_3 43.28 1.08 2223 642911484 XP_008199443.1 1321 9.6e-143 PREDICTED: uncharacterized protein LOC662426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15599 151 1.8e-08 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens GN=SLC9A3R2 PE=1 SV=2 PF00595//PF13180//PF03145//PF14634//PF13639 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Seven in absentia protein family//zinc-RING finger domain//Ring finger domain GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.32698 BP_3 82.00 2.41 1934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3270 BP_3 103.90 9.34 828 91092914 XP_971430.1 888 5.8e-93 PREDICTED: DNA-directed RNA polymerase III subunit RPC8 [Tribolium castaneum]>gi|642916922|ref|XP_008199556.1| PREDICTED: DNA-directed RNA polymerase III subunit RPC8 [Tribolium castaneum]>gi|270003098|gb|EEZ99545.1| hypothetical protein TcasGA2_TC000127 [Tribolium castaneum] -- -- -- -- -- K03022 RPC8, POLR3H DNA-directed RNA polymerase III subunit RPC8 http://www.genome.jp/dbget-bin/www_bget?ko:K03022 Q9D2C6 642 7.9e-66 DNA-directed RNA polymerase III subunit RPC8 OS=Mus musculus GN=Polr3h PE=2 SV=2 PF03876 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3297 DNA-directed RNA polymerase subunit E' Cluster-8309.32703 BP_3 538.55 4.07 6674 91090320 XP_972446.1 3083 0.0e+00 PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|642934930|ref|XP_008197867.1| PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|270013809|gb|EFA10257.1| hypothetical protein TcasGA2_TC012457 [Tribolium castaneum] 642934932 XM_967353.2 859 0 PREDICTED: Tribolium castaneum rho-related BTB domain-containing protein 2 (LOC661174), transcript variant X3, mRNA K07868 RHOBTB1_2 Rho-related BTB domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07868 Q9DAK3 1118 4.1e-120 Rho-related BTB domain-containing protein 1 OS=Mus musculus GN=Rhobtb1 PE=1 SV=2 PF00071//PF08477//PF00651 Ras family//Ras of Complex, Roc, domain of DAPkinase//BTB/POZ domain GO:0007264 small GTPase mediated signal transduction GO:0005515//GO:0005525 protein binding//GTP binding GO:0005622 intracellular -- -- Cluster-8309.32708 BP_3 8.00 0.61 926 642925814 XP_970128.3 386 1.0e-34 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 227 1.2e-17 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01370//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0050662//GO:0003824 oxidoreductase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.32709 BP_3 878.46 11.44 3992 91081955 XP_967420.1 3702 0.0e+00 PREDICTED: cullin-3 [Tribolium castaneum]>gi|270007361|gb|EFA03809.1| hypothetical protein TcasGA2_TC013922 [Tribolium castaneum] 755982854 XM_011311736.1 344 1.07099e-177 PREDICTED: Fopius arisanus cullin-3 (LOC105270650), mRNA K03869 CUL3 cullin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03869 B5DF89 3025 0.0e+00 Cullin-3 OS=Rattus norvegicus GN=Cul3 PE=1 SV=2 PF02023//PF00888//PF12422 SCAN domain//Cullin family//Condensin II non structural maintenance of chromosomes subunit GO:0006511//GO:0006355 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0031625 transcription factor activity, sequence-specific DNA binding//ubiquitin protein ligase binding GO:0005667//GO:0005634//GO:0031461 transcription factor complex//nucleus//cullin-RING ubiquitin ligase complex KOG2166 Cullins Cluster-8309.32712 BP_3 54.59 2.69 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32713 BP_3 2521.50 54.84 2508 478263397 ENN81769.1 862 1.8e-89 hypothetical protein YQE_01862, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NDA2 232 8.4e-18 Hemicentin-2 OS=Homo sapiens GN=HMCN2 PE=2 SV=2 PF01108//PF13895//PF15491//PF00041//PF16656 Tissue factor//Immunoglobulin domain//CST, telomere maintenance, complex subunit CTC1//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0000723//GO:0006771//GO:0019497 telomere maintenance//riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.32715 BP_3 32.15 1.48 1336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32716 BP_3 7.00 18.10 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32717 BP_3 1364.82 36.38 2100 91076586 XP_968109.1 1304 8.5e-141 PREDICTED: ras suppressor protein 1 [Tribolium castaneum] 642912649 XM_963016.3 201 1.74119e-98 PREDICTED: Tribolium castaneum ras suppressor protein 1 (LOC656490), mRNA -- -- -- -- Q5E9C0 888 6.0e-94 Ras suppressor protein 1 OS=Bos taurus GN=RSU1 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.32720 BP_3 15.00 10.81 354 642937488 XP_008198860.1 261 1.2e-20 PREDICTED: protein tramtrack, beta isoform-like isoform X21 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32721 BP_3 1188.87 48.92 1463 91081331 XP_970657.1 1014 2.5e-107 PREDICTED: Krueppel homolog 2 [Tribolium castaneum]>gi|270005195|gb|EFA01643.1| hypothetical protein TcasGA2_TC007213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V447 663 5.2e-68 Krueppel homolog 2 OS=Drosophila melanogaster GN=Kr-h2 PE=1 SV=1 PF03661 Uncharacterised protein family (UPF0121) -- -- -- -- GO:0016021 integral component of membrane KOG4002 Uncharacterized integral membrane protein Cluster-8309.32722 BP_3 134.18 10.72 895 91083773 XP_972220.1 361 8.0e-32 PREDICTED: uncharacterized protein LOC660933 [Tribolium castaneum]>gi|270006783|gb|EFA03231.1| hypothetical protein TcasGA2_TC013160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01084//PF01395//PF00335 Ribosomal protein S18//PBP/GOBP family//Tetraspanin family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005549 structural constituent of ribosome//odorant binding GO:0005840//GO:0016021//GO:0005622 ribosome//integral component of membrane//intracellular -- -- Cluster-8309.32723 BP_3 25.50 0.44 3096 91077034 XP_967567.1 1173 1.9e-125 PREDICTED: cysteine and histidine-rich domain-containing protein [Tribolium castaneum]>gi|270001750|gb|EEZ98197.1| hypothetical protein TcasGA2_TC000627 [Tribolium castaneum] -- -- -- -- -- K16729 CHORDC1, CHP1 cysteine and histidine-rich domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16729 Q9VCC0 980 1.9e-104 Cysteine and histidine-rich domain-containing protein OS=Drosophila melanogaster GN=CHORD PE=1 SV=1 PF03473//PF00779//PF01082 MOSC domain//BTK motif//Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0003824//GO:0005507//GO:0030170//GO:0004497//GO:0030151//GO:0016715 catalytic activity//copper ion binding//pyridoxal phosphate binding//monooxygenase activity//molybdenum ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.32724 BP_3 710.00 11.96 3152 546678469 ERL89077.1 1054 1.2e-111 hypothetical protein D910_06454 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF06881 F-box domain//RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.32725 BP_3 1266.02 11.34 5673 642927080 XP_008195128.1 5567 0.0e+00 PREDICTED: intron-binding protein aquarius [Tribolium castaneum] 602701425 XM_007462507.1 236 1.66129e-117 PREDICTED: Lipotes vexillifer aquarius intron-binding spliceosomal factor (AQR), mRNA K12874 AQR intron-binding protein aquarius http://www.genome.jp/dbget-bin/www_bget?ko:K12874 O60306 4522 0.0e+00 Intron-binding protein aquarius OS=Homo sapiens GN=AQR PE=1 SV=4 PF00004//PF00154//PF07728//PF03796//PF01057//PF00270//PF02337//PF00580//PF02562//PF04851//PF06414 ATPase family associated with various cellular activities (AAA)//recA bacterial DNA recombination protein//AAA domain (dynein-related subfamily)//DnaB-like helicase C terminal domain//Parvovirus non-structural protein NS1//DEAD/DEAH box helicase//Retroviral GAG p10 protein//UvrD/REP helicase N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit//Zeta toxin GO:0009432//GO:0006260//GO:0006281//GO:0019079 SOS response//DNA replication//DNA repair//viral genome replication GO:0016887//GO:0016301//GO:0003676//GO:0005198//GO:0003678//GO:0005524//GO:0016787//GO:0003677//GO:0003697 ATPase activity//kinase activity//nucleic acid binding//structural molecule activity//DNA helicase activity//ATP binding//hydrolase activity//DNA binding//single-stranded DNA binding GO:0005657//GO:0019028 replication fork//viral capsid KOG1806 DEAD box containing helicases Cluster-8309.32726 BP_3 133.98 2.60 2778 642927080 XP_008195128.1 3495 0.0e+00 PREDICTED: intron-binding protein aquarius [Tribolium castaneum] 564234202 XM_006273981.1 149 1.86423e-69 PREDICTED: Alligator mississippiensis aquarius intron-binding spliceosomal factor (AQR), mRNA K12874 AQR intron-binding protein aquarius http://www.genome.jp/dbget-bin/www_bget?ko:K12874 O60306 2535 8.3e-285 Intron-binding protein aquarius OS=Homo sapiens GN=AQR PE=1 SV=4 PF00270//PF00910//PF02337//PF00580//PF02456//PF02562//PF06414//PF04851//PF00004//PF07728//PF01057//PF05496//PF03796//PF06068 DEAD/DEAH box helicase//RNA helicase//Retroviral GAG p10 protein//UvrD/REP helicase N-terminal domain//Adenovirus IVa2 protein//PhoH-like protein//Zeta toxin//Type III restriction enzyme, res subunit//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//DnaB-like helicase C terminal domain//TIP49 C-terminus GO:0006310//GO:0006260//GO:0019079//GO:0019083//GO:0006281 DNA recombination//DNA replication//viral genome replication//viral transcription//DNA repair GO:0003676//GO:0009378//GO:0003724//GO:0003678//GO:0003723//GO:0003677//GO:0016301//GO:0016887//GO:0005524//GO:0016787//GO:0005198 nucleic acid binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding//DNA binding//kinase activity//ATPase activity//ATP binding//hydrolase activity//structural molecule activity GO:0005657//GO:0009379//GO:0019028 replication fork//Holliday junction helicase complex//viral capsid KOG1806 DEAD box containing helicases Cluster-8309.32727 BP_3 16.00 94.73 258 332376611 AEE63445.1 154 2.3e-08 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32728 BP_3 75.48 1.51 2701 642928332 XP_008195538.1 754 6.5e-77 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 P81139 302 6.9e-26 Pancreatic lipase-related protein 2 OS=Cavia porcellus GN=PNLIPRP2 PE=1 SV=1 PF01764//PF12740//PF07859//PF07819//PF00326//PF06821//PF00975 Lipase (class 3)//Chlorophyllase enzyme//alpha/beta hydrolase fold//PGAP1-like protein//Prolyl oligopeptidase family//Serine hydrolase//Thioesterase domain GO:0008152//GO:0006505//GO:0015996//GO:0015994//GO:0006886//GO:0006629//GO:0006508//GO:0009058 metabolic process//GPI anchor metabolic process//chlorophyll catabolic process//chlorophyll metabolic process//intracellular protein transport//lipid metabolic process//proteolysis//biosynthetic process GO:0016788//GO:0016787//GO:0047746//GO:0008236 hydrolase activity, acting on ester bonds//hydrolase activity//chlorophyllase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.32729 BP_3 237.03 7.06 1909 332373514 AEE61898.1 538 5.1e-52 unknown [Dendroctonus ponderosae] 642934342 XM_008200388.1 93 1.72015e-38 PREDICTED: Tribolium castaneum uncharacterized LOC103314398 (LOC103314398), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32730 BP_3 7.06 0.42 1095 332373222 AEE61752.1 378 1.0e-33 unknown [Dendroctonus ponderosae] 70909738 AM049056.1 123 2.04993e-55 Timarcha balearica mRNA for ribosomal protein L18e (rpL18e gene) K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q4GXG7 372 2.1e-34 60S ribosomal protein L18 OS=Timarcha balearica GN=RpL18 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1714 60s ribosomal protein L18 Cluster-8309.32731 BP_3 320.00 22.15 988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32732 BP_3 316.05 4.13 3977 146411532 ABQ39970.1 2297 1.1e-255 heat shock protein 70 [Anatolica polita borealis] 645000994 XM_001599723.3 308 1.09755e-157 PREDICTED: Nasonia vitripennis heat shock protein 68-like (LOC100114907), mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P41825 2118 2.7e-236 Heat shock protein 70 A1 OS=Anopheles albimanus GN=HSP70A1 PE=3 SV=1 PF01968//PF00560//PF02782//PF13855//PF06723 Hydantoinase/oxoprolinase//Leucine Rich Repeat//FGGY family of carbohydrate kinases, C-terminal domain//Leucine rich repeat//MreB/Mbl protein GO:0000902//GO:0005975 cell morphogenesis//carbohydrate metabolic process GO:0016787//GO:0016773//GO:0005515 hydrolase activity//phosphotransferase activity, alcohol group as acceptor//protein binding -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.32733 BP_3 414.23 3.50 5989 642936804 XP_008199623.1 5539 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 6.7e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF07926//PF10473//PF06160//PF08702//PF00910//PF01695//PF07728//PF04111//PF16326//PF00004//PF13851//PF16716//PF01832 TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Fibrinogen alpha/beta chain family//RNA helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Autophagy protein Apg6//ABC transporter C-terminal domain//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//Bone marrow stromal antigen 2//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase GO:0030168//GO:0018874//GO:0048870//GO:0000921//GO:0006560//GO:0051607//GO:0006568//GO:0006558//GO:0006606//GO:0042207//GO:0006525//GO:0007165//GO:0051258//GO:0006914 platelet activation//benzoate metabolic process//cell motility//septin ring assembly//proline metabolic process//defense response to virus//tryptophan metabolic process//L-phenylalanine metabolic process//protein import into nucleus//styrene catabolic process//arginine metabolic process//signal transduction//protein polymerization//autophagy GO:0030674//GO:0042803//GO:0003724//GO:0003677//GO:0003723//GO:0004040//GO:0005102//GO:0016887//GO:0005524//GO:0008134//GO:0045502 protein binding, bridging//protein homodimerization activity//RNA helicase activity//DNA binding//RNA binding//amidase activity//receptor binding//ATPase activity//ATP binding//transcription factor binding//dynein binding GO:0030286//GO:0005667//GO:0005577//GO:0031514//GO:0016021//GO:0005940 dynein complex//transcription factor complex//fibrinogen complex//motile cilium//integral component of membrane//septin ring -- -- Cluster-8309.32735 BP_3 909.18 20.06 2476 642920452 XP_008192356.1 1383 6.9e-150 PREDICTED: protein croquemort isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 956 9.3e-102 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.32737 BP_3 284.45 19.58 992 817194376 XP_012272686.1 1072 3.2e-114 PREDICTED: 40S ribosomal protein S4 [Orussus abietinus] 264667394 GU120433.1 298 9.66998e-153 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 1090 1.1e-117 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.32738 BP_3 67.87 0.63 5478 688589261 XP_009290233.1 275 4.6e-21 PREDICTED: zinc finger and SCAN domain containing 2-like isoform X1 [Danio rerio] 817210508 XM_012425923.1 150 1.02871e-69 PREDICTED: Orussus abietinus uncharacterized LOC105700249 (LOC105700249), mRNA K09203 EGR1 early growth response protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09203 Q99676 246 4.4e-19 Zinc finger protein 184 OS=Homo sapiens GN=ZNF184 PE=1 SV=4 PF13465//PF00076//PF16367//PF13912//PF02892//PF00096//PF05495//PF03868//PF02207//PF05478 Zinc-finger double domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//CHY zinc finger//Ribosomal protein L6, N-terminal domain//Putative zinc finger in N-recognin (UBR box)//Prominin GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735//GO:0003676//GO:0046872//GO:0003677 zinc ion binding//structural constituent of ribosome//nucleic acid binding//metal ion binding//DNA binding GO:0005840//GO:0005622//GO:0016021 ribosome//intracellular//integral component of membrane -- -- Cluster-8309.32741 BP_3 438.06 37.35 857 264667363 ACY71267.1 534 6.7e-52 ribosomal protein S24 [Chrysomela tremula] 642917806 XM_962484.3 218 2.46159e-108 PREDICTED: Tribolium castaneum 40S ribosomal protein S24 (LOC655928), mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 Q962Q6 511 1.3e-50 40S ribosomal protein S24 OS=Spodoptera frugiperda GN=RpS24 PE=2 SV=1 PF01282//PF00276 Ribosomal protein S24e//Ribosomal protein L23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3424 40S ribosomal protein S24 Cluster-8309.32742 BP_3 1752.36 11.00 7971 642926973 XP_008195085.1 3274 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 8.7e-77 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF00130//PF05529//PF00621//PF03650//PF07649//PF05791//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//B-cell receptor-associated protein 31-like//RhoGEF domain//Uncharacterised protein family (UPF0041)//C1-like domain//Bacillus haemolytic enterotoxin (HBL)//PHD-finger GO:0006850//GO:0006886//GO:0009405//GO:0035023//GO:0055114//GO:0035556//GO:0043087 mitochondrial pyruvate transport//intracellular protein transport//pathogenesis//regulation of Rho protein signal transduction//oxidation-reduction process//intracellular signal transduction//regulation of GTPase activity GO:0005515//GO:0005089//GO:0047134 protein binding//Rho guanyl-nucleotide exchange factor activity//protein-disulfide reductase activity GO:0005783//GO:0016021//GO:0005743//GO:0016020 endoplasmic reticulum//integral component of membrane//mitochondrial inner membrane//membrane -- -- Cluster-8309.32743 BP_3 180.00 5.41 1896 642921071 XP_008192680.1 188 2.0e-11 PREDICTED: muscle LIM protein Mlp84B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24400 137 6.6e-07 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32744 BP_3 92.21 0.49 9449 642926969 XP_008195083.1 2249 1.0e-249 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X1 [Tribolium castaneum]>gi|642926971|ref|XP_008195084.1| PREDICTED: rho guanine nucleotide exchange factor 18 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 1.0e-76 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF06206//PF00621//PF05791//PF03650//PF10186//PF08031 CpeT/CpcT family (DUF1001)//RhoGEF domain//Bacillus haemolytic enterotoxin (HBL)//Uncharacterised protein family (UPF0041)//Vacuolar sorting 38 and autophagy-related subunit 14//Berberine and berberine like GO:0055114//GO:0017009//GO:0010508//GO:0043087//GO:0006850//GO:0035023//GO:0009405 oxidation-reduction process//protein-phycocyanobilin linkage//positive regulation of autophagy//regulation of GTPase activity//mitochondrial pyruvate transport//regulation of Rho protein signal transduction//pathogenesis GO:0005089//GO:0050660//GO:0016491 Rho guanyl-nucleotide exchange factor activity//flavin adenine dinucleotide binding//oxidoreductase activity GO:0016020//GO:0005743 membrane//mitochondrial inner membrane -- -- Cluster-8309.32746 BP_3 140.70 4.80 1705 91084999 XP_973197.1 1693 5.4e-186 PREDICTED: TBC1 domain family member 10A [Tribolium castaneum]>gi|270009019|gb|EFA05467.1| hypothetical protein TcasGA2_TC015650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHL3 888 4.9e-94 TBC1 domain family member 10B OS=Mus musculus GN=Tbc1d10b PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634//GO:0005622 nucleus//intracellular KOG2221 PDZ-domain interacting protein EPI64, contains TBC domain Cluster-8309.32747 BP_3 1016.27 29.08 1976 642916102 XP_971729.2 1781 3.9e-196 PREDICTED: DDB1- and CUL4-associated factor 11 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q5E9I8 1238 1.5e-134 DDB1- and CUL4-associated factor 11 OS=Bos taurus GN=DCAF11 PE=2 SV=1 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG0266 WD40 repeat-containing protein Cluster-8309.32748 BP_3 1098.00 116.50 746 91077450 XP_967239.1 323 1.7e-27 PREDICTED: guanine nucleotide-binding protein subunit gamma-1 [Tribolium castaneum]>gi|270002133|gb|EEZ98580.1| hypothetical protein TcasGA2_TC001094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P38040 231 3.3e-18 Guanine nucleotide-binding protein subunit gamma-1 OS=Drosophila melanogaster GN=Ggamma1 PE=2 SV=1 PF00631 GGL domain GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex -- -- Cluster-8309.3275 BP_3 2.00 1.20 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32751 BP_3 413.47 4.57 4653 270012482 EFA08930.1 2066 8.2e-229 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 992 1.2e-105 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.32752 BP_3 185.41 1.89 5009 270012482 EFA08930.1 2066 8.8e-229 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 992 1.3e-105 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.32753 BP_3 556.35 12.06 2515 642935097 XP_008197884.1 1820 1.5e-200 PREDICTED: probable RNA methyltransferase bin3 isoform X1 [Tribolium castaneum]>gi|270013396|gb|EFA09844.1| hypothetical protein TcasGA2_TC011992 [Tribolium castaneum] -- -- -- -- -- K15190 MEPCE, BCDIN3 7SK snRNA methylphosphate capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15190 Q8K3A9 597 4.0e-60 7SK snRNA methylphosphate capping enzyme OS=Mus musculus GN=Mepce PE=1 SV=2 PF05958//PF08241//PF02390//PF05175//PF03810//PF01135//PF08123//PF05401//PF06859 tRNA (Uracil-5-)-methyltransferase//Methyltransferase domain//Putative methyltransferase//Methyltransferase small domain//Importin-beta N-terminal domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Histone methylation protein DOT1//Nodulation protein S (NodS)//Bicoid-interacting protein 3 (Bin3) GO:0009877//GO:0009451//GO:0006479//GO:0006400//GO:0046500//GO:0008152//GO:0008033//GO:0006396//GO:0006554//GO:0006464//GO:0009312//GO:0006886 nodulation//RNA modification//protein methylation//tRNA modification//S-adenosylmethionine metabolic process//metabolic process//tRNA processing//RNA processing//lysine catabolic process//cellular protein modification process//oligosaccharide biosynthetic process//intracellular protein transport GO:0008176//GO:0004719//GO:0018024//GO:0008757//GO:0008536//GO:0008173//GO:0008168 tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//histone-lysine N-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//Ran GTPase binding//RNA methyltransferase activity//methyltransferase activity -- -- KOG2899 Predicted methyltransferase Cluster-8309.32754 BP_3 353.00 14.49 1466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32755 BP_3 878.00 22.32 2188 546676390 ERL87412.1 1604 1.4e-175 hypothetical protein D910_04807 [Dendroctonus ponderosae] -- -- -- -- -- K18726 FAF2, UBXD8 FAS-associated factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18726 Q28BP9 840 2.3e-88 FAS-associated factor 2 OS=Xenopus tropicalis GN=faf2 PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.32756 BP_3 506.69 4.15 6183 642911068 XP_008200561.1 1643 1.2e-179 PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum]>gi|642911070|ref|XP_008200562.1| PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum] 642911069 XM_008202340.1 599 0 PREDICTED: Tribolium castaneum ELAV-like protein 4 (LOC659897), transcript variant X2, mRNA K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 Q28GD4 1057 4.5e-113 ELAV-like protein 2 OS=Xenopus tropicalis GN=elavl2 PE=2 SV=2 PF08675//PF00076//PF16367//PF08777 RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.32757 BP_3 24.34 0.79 1785 270010830 EFA07278.1 1128 1.8e-120 hypothetical protein TcasGA2_TC014512 [Tribolium castaneum] 299884466 FP926002.1 78 3.50177e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51023 606 2.6e-61 ETS-like protein pointed, isoform P2/D OS=Drosophila melanogaster GN=pnt PE=2 SV=2 PF00447//PF00178 HSF-type DNA-binding//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.32760 BP_3 254.85 0.80 15586 642914058 XP_008201527.1 14432 0.0e+00 PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3114 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00307//PF11616//PF00018//PF14604//PF00435 Calponin homology (CH) domain//WD repeat binding protein EZH2//SH3 domain//Variant SH3 domain//Spectrin repeat GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.32761 BP_3 4153.24 19.74 10435 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436//PF07442 NHL repeat//Ponericin -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.32762 BP_3 19.68 0.69 1660 189235746 XP_967247.2 510 7.8e-49 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 307 1.1e-26 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF08117//PF02137 Ptu family//Adenosine-deaminase (editase) domain GO:0006807//GO:0006396//GO:0009405//GO:0006144//GO:0006810 nitrogen compound metabolic process//RNA processing//pathogenesis//purine nucleobase metabolic process//transport GO:0019855//GO:0003723//GO:0004000 calcium channel inhibitor activity//RNA binding//adenosine deaminase activity GO:0005576 extracellular region KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.32763 BP_3 35.57 0.55 3434 642926401 XP_008191947.1 2363 2.2e-263 PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|642926403|ref|XP_008191948.1| PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|270009223|gb|EFA05671.1| hormone receptor in 39-like protein [Tribolium castaneum] 642926402 XM_008193726.1 91 4.03345e-37 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 beta (LOC658947), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 Q05192 989 1.9e-105 Nuclear hormone receptor FTZ-F1 beta OS=Drosophila melanogaster GN=Hr39 PE=1 SV=3 PF00104//PF00105//PF03846 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains)//Cell division inhibitor SulA GO:0007165//GO:0009432//GO:0051782//GO:0006355//GO:0043401 signal transduction//SOS response//negative regulation of cell division//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003707//GO:0046872//GO:0003700//GO:0008270//GO:0043565 steroid hormone receptor activity//metal ion binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0009276//GO:0005634 transcription factor complex//Gram-negative-bacterium-type cell wall//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.32764 BP_3 134.56 5.27 1522 478251030 ENN71511.1 1526 1.1e-166 hypothetical protein YQE_11804, partial [Dendroctonus ponderosae]>gi|546679470|gb|ERL89934.1| hypothetical protein D910_07293 [Dendroctonus ponderosae] -- -- -- -- -- K16815 PNPLA8 calcium-independent phospholipase A2-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16815 Q9NP80 974 4.7e-104 Calcium-independent phospholipase A2-gamma OS=Homo sapiens GN=PNPLA8 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.32766 BP_3 1486.00 86.16 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32767 BP_3 191.09 2.74 3654 91084659 XP_967590.1 881 1.7e-91 PREDICTED: protein GUCD1 isoform X2 [Tribolium castaneum]>gi|270008923|gb|EFA05371.1| hypothetical protein TcasGA2_TC015537 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 1.5e-39 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284//PF03412 Cytochrome c oxidase subunit Va//Peptidase C39 family GO:0006123//GO:0015992//GO:0006508 mitochondrial electron transport, cytochrome c to oxygen//proton transport//proteolysis GO:0005524//GO:0008233//GO:0004129 ATP binding//peptidase activity//cytochrome-c oxidase activity GO:0045277//GO:0005743//GO:0016021 respiratory chain complex IV//mitochondrial inner membrane//integral component of membrane KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.32769 BP_3 5.00 3.00 369 390369787 XP_003731711.1 236 1.0e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 198 1.1e-14 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.32770 BP_3 658.27 27.07 1464 91093034 XP_970412.1 1010 7.3e-107 PREDICTED: transmembrane protein 183 [Tribolium castaneum]>gi|270002700|gb|EEZ99147.1| hypothetical protein TcasGA2_TC012928 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R8D5 475 3.3e-46 Transmembrane protein 183 OS=Pongo abelii GN=TMEM183 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32774 BP_3 602.86 4.58 6640 270007202 EFA03650.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013744 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.90452e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 O88477 954 4.2e-101 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Mus musculus GN=Igf2bp1 PE=1 SV=1 PF00076//PF07650//PF04061//PF00013//PF13014//PF13184 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//KH domain//ORMDL family//KH domain//KH domain//NusA-like KH domain -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.32779 BP_3 66.15 1.39 2591 91092388 XP_968476.1 2123 1.1e-235 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 1.11497e-21 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32780 BP_3 132.14 1.13 5929 189236651 XP_969621.2 1951 2.3e-215 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 2 [Tribolium castaneum]>gi|270005204|gb|EFA01652.1| hypothetical protein TcasGA2_TC007223 [Tribolium castaneum] 642920726 XM_964528.3 359 0 PREDICTED: Tribolium castaneum polypeptide N-acetylgalactosaminyltransferase 2 (LOC658118), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV19 1535 1.6e-168 Polypeptide N-acetylgalactosaminyltransferase 2 OS=Drosophila melanogaster GN=pgant2 PE=2 SV=2 PF13855//PF00558//PF00560 Leucine rich repeat//Vpu protein//Leucine Rich Repeat GO:0019076//GO:0006486//GO:0006812//GO:0032801 viral release from host cell//protein glycosylation//cation transport//receptor catabolic process GO:0016757//GO:0005261//GO:0005515 transferase activity, transferring glycosyl groups//cation channel activity//protein binding GO:0016021//GO:0005794//GO:0033644 integral component of membrane//Golgi apparatus//host cell membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.32781 BP_3 62.18 1.18 2840 642927136 XP_972282.2 1000 2.0e-105 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6QHF9 273 1.7e-22 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593//PF00858 Flavin containing amine oxidoreductase//Amiloride-sensitive sodium channel GO:0006814//GO:0055114 sodium ion transport//oxidation-reduction process GO:0005272//GO:0016491 sodium channel activity//oxidoreductase activity GO:0016020 membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.32784 BP_3 3.00 1.70 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32785 BP_3 12.27 0.44 1642 478250645 ENN71137.1 868 2.4e-90 hypothetical protein YQE_12068, partial [Dendroctonus ponderosae] -- -- -- -- -- K17525 CHID1 chitinase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17525 A0JPQ9 497 1.0e-48 Chitinase domain-containing protein 1 OS=Rattus norvegicus GN=Chid1 PE=2 SV=2 PF00704//PF03644 Glycosyl hydrolases family 18//Glycosyl hydrolase family 85 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0033925 hydrolase activity, hydrolyzing O-glycosyl compounds//mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2091 Predicted member of glycosyl hydrolase family 18 Cluster-8309.32787 BP_3 548.76 21.82 1504 91086851 XP_974311.1 638 1.0e-63 PREDICTED: vacuolar protein-sorting-associated protein 25 [Tribolium castaneum]>gi|270010461|gb|EFA06909.1| hypothetical protein TcasGA2_TC009858 [Tribolium castaneum] -- -- -- -- -- K12189 VPS25, EAP20 ESCRT-II complex subunit VPS25 http://www.genome.jp/dbget-bin/www_bget?ko:K12189 Q6NWF4 431 4.2e-41 Vacuolar protein-sorting-associated protein 25 OS=Danio rerio GN=vps25 PE=2 SV=2 PF07749 Endoplasmic reticulum protein ERp29, C-terminal domain -- -- -- -- GO:0005783 endoplasmic reticulum KOG4068 Uncharacterized conserved protein Cluster-8309.32788 BP_3 15.38 0.43 2020 642928992 XP_008195647.1 1526 1.5e-166 PREDICTED: endoplasmic reticulum metallopeptidase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVK0 775 7.3e-81 Endoplasmic reticulum metallopeptidase 1 OS=Mus musculus GN=Ermp1 PE=2 SV=2 PF01546//PF15168 Peptidase family M20/M25/M40//Triple QxxK/R motif-containing protein family GO:0008152 metabolic process GO:0016787 hydrolase activity GO:0005789 endoplasmic reticulum membrane KOG2194 Aminopeptidases of the M20 family Cluster-8309.32789 BP_3 14.10 0.38 2077 332374052 AEE62167.1 903 2.6e-94 unknown [Dendroctonus ponderosae]>gi|478263264|gb|ENN81648.1| hypothetical protein YQE_01946, partial [Dendroctonus ponderosae]>gi|546673295|gb|ERL84927.1| hypothetical protein D910_02350 [Dendroctonus ponderosae] 551506028 XM_005804490.1 134 3.02745e-61 PREDICTED: Xiphophorus maculatus ubiquitin-conjugating enzyme E2 E2-like (LOC102229941), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P52485 836 6.4e-88 Ubiquitin-conjugating enzyme E2-24 kDa OS=Drosophila melanogaster GN=UbcD2 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.32791 BP_3 97.59 1.35 3776 512892422 XP_004922927.1 1009 2.5e-106 PREDICTED: uncharacterized protein LOC101739908 [Bombyx mori] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 388 1.0e-35 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.32792 BP_3 505.00 18.39 1615 91083221 XP_973529.1 638 1.1e-63 PREDICTED: DNA replication complex GINS protein SLD5 [Tribolium castaneum]>gi|270006961|gb|EFA03409.1| hypothetical protein TcasGA2_TC013396 [Tribolium castaneum] -- -- -- -- -- K10735 GINS4, SLD5 GINS complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10735 Q99LZ3 407 2.8e-38 DNA replication complex GINS protein SLD5 OS=Mus musculus GN=Gins4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3176 Predicted alpha-helical protein, potentially involved in replication/repair Cluster-8309.32793 BP_3 537.20 5.06 5409 642929544 XP_975258.3 1155 4.1e-123 PREDICTED: KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14942 KHDRBS3, SLM2 KH domain-containing, RNA-binding, signal transduction-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14942 Q5VWX1 417 6.4e-39 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Homo sapiens GN=KHDRBS2 PE=1 SV=1 PF13014//PF00013//PF06667 KH domain//KH domain//Phage shock protein B GO:0006355//GO:0009271 regulation of transcription, DNA-templated//phage shock GO:0003723 RNA binding -- -- -- -- Cluster-8309.32794 BP_3 134.47 4.43 1754 478250772 ENN71264.1 1759 1.2e-193 hypothetical protein YQE_12190, partial [Dendroctonus ponderosae] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q5F485 1207 5.1e-131 ATP-dependent RNA helicase DDX42 OS=Gallus gallus GN=DDX42 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0339 ATP-dependent RNA helicase Cluster-8309.32795 BP_3 38.79 0.44 4549 642910503 XP_008200242.1 2679 6.6e-300 PREDICTED: phospholipase DDHD2 isoform X1 [Tribolium castaneum] 826487484 XM_012683938.1 80 6.97887e-31 PREDICTED: Monomorium pharaonis SEC23-interacting protein-like (LOC105838396), transcript variant X4, mRNA -- -- -- -- Q9Y6Y8 1018 1.1e-108 SEC23-interacting protein OS=Homo sapiens GN=SEC23IP PE=1 SV=1 PF13724//PF02862 DNA-binding domain//DDHD domain -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.32796 BP_3 10080.26 274.46 2062 91092312 XP_969869.1 565 4.1e-55 PREDICTED: transcriptional regulator DEF1 [Tribolium castaneum]>gi|270015692|gb|EFA12140.1| hypothetical protein TcasGA2_TC002287 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32797 BP_3 189.66 5.63 1914 91081331 XP_970657.1 567 2.2e-55 PREDICTED: Krueppel homolog 2 [Tribolium castaneum]>gi|270005195|gb|EFA01643.1| hypothetical protein TcasGA2_TC007213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V447 370 6.4e-34 Krueppel homolog 2 OS=Drosophila melanogaster GN=Kr-h2 PE=1 SV=1 PF03661 Uncharacterised protein family (UPF0121) -- -- -- -- GO:0016021 integral component of membrane KOG4002 Uncharacterized integral membrane protein Cluster-8309.32799 BP_3 48.02 2.13 1380 -- -- -- -- -- 768311757 CP010985.1 1304 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32801 BP_3 92.76 0.54 8629 270011427 EFA07875.1 6305 0.0e+00 hypothetical protein TcasGA2_TC005449 [Tribolium castaneum] 642933139 XM_008199051.1 245 2.51352e-122 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 3.2e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF06333//PF14672//PF02671 Mediator complex subunit 13 C-terminal//Late cornified envelope//Paired amphipathic helix repeat GO:0008544//GO:0006355//GO:0006357 epidermis development//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.32803 BP_3 308.60 6.39 2618 189239691 XP_974700.2 1611 2.7e-176 PREDICTED: probable phenylalanine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270010728|gb|EFA07176.1| hypothetical protein TcasGA2_TC010176 [Tribolium castaneum] -- -- -- -- -- K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 O16129 1377 1.5e-150 Probable phenylalanine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-phe PE=2 SV=3 PF00152//PF03147//PF01409 tRNA synthetases class II (D, K and N)//Ferredoxin-fold anticodon binding domain//tRNA synthetases class II core domain (F) GO:0006432//GO:0000162//GO:0006571//GO:0043039//GO:0008033//GO:0009094//GO:0006418 phenylalanyl-tRNA aminoacylation//tryptophan biosynthetic process//tyrosine biosynthetic process//tRNA aminoacylation//tRNA processing//L-phenylalanine biosynthetic process//tRNA aminoacylation for protein translation GO:0000049//GO:0004826//GO:0005524//GO:0004812//GO:0000287//GO:0000166 tRNA binding//phenylalanine-tRNA ligase activity//ATP binding//aminoacyl-tRNA ligase activity//magnesium ion binding//nucleotide binding GO:0005737//GO:0009328 cytoplasm//phenylalanine-tRNA ligase complex KOG2783 Phenylalanyl-tRNA synthetase Cluster-8309.32804 BP_3 156.52 3.15 2686 642935171 XP_008199676.1 280 5.9e-22 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q9JLJ5 169 1.8e-10 Elongation of very long chain fatty acids protein 1 OS=Mus musculus GN=Elovl1 PE=2 SV=1 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32805 BP_3 1022.86 15.21 3534 389611375 BAM19299.1 995 9.6e-105 elongase [Papilio polytes] 642935170 XM_008201454.1 67 9.1159e-24 PREDICTED: Tribolium castaneum elongation of very long chain fatty acids protein AAEL008004 (LOC655397), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 726 6.2e-75 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32806 BP_3 260.33 1.83 7150 642933564 XP_008197473.1 1589 2.6e-173 PREDICTED: serine-enriched protein isoform X6 [Tribolium castaneum] 749773347 XM_011143789.1 272 2.03716e-137 PREDICTED: Harpegnathos saltator serine-enriched protein-like (LOC105184770), partial mRNA -- -- -- -- O61366 1396 2.5e-152 Serine-enriched protein OS=Drosophila melanogaster GN=gprs PE=3 SV=3 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.32807 BP_3 1331.00 63.94 1295 91091954 XP_968265.1 1695 2.4e-186 PREDICTED: eukaryotic translation initiation factor 3 subunit M [Tribolium castaneum]>gi|270000777|gb|EEZ97224.1| hypothetical protein TcasGA2_TC011022 [Tribolium castaneum] 766938025 XM_011503194.1 111 1.14031e-48 PREDICTED: Ceratosolen solmsi marchali eukaryotic translation initiation factor 3 subunit M (LOC105365102), mRNA K15030 EIF3M translation initiation factor 3 subunit M http://www.genome.jp/dbget-bin/www_bget?ko:K15030 Q17D30 1397 3.5e-153 Eukaryotic translation initiation factor 3 subunit M OS=Aedes aegypti GN=AAEL004347 PE=3 SV=1 PF02637//PF01399 GatB domain//PCI domain -- -- GO:0016884//GO:0005515 carbon-nitrogen ligase activity, with glutamine as amido-N-donor//protein binding -- -- KOG2753 Uncharacterized conserved protein, contains PCI domain Cluster-8309.32808 BP_3 39.02 0.60 3434 642935023 XP_008199910.1 1215 2.9e-130 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 770 4.7e-80 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF08925//PF16367//PF11547//PF00076 Domain of Unknown Function (DUF1907)//RNA recognition motif//E3 ubiquitin ligase EDD//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0043130 nucleic acid binding//ubiquitin binding GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.32809 BP_3 1822.01 78.53 1410 237681162 NP_001153726.1 927 2.9e-97 glyoxylate reductase/hydroxypyruvate reductase-like [Tribolium castaneum]>gi|270012386|gb|EFA08834.1| LOW QUALITY PROTEIN: hypothetical protein TcasGA2_TC006532 [Tribolium castaneum] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q91Z53 551 4.8e-55 Glyoxylate reductase/hydroxypyruvate reductase OS=Mus musculus GN=Grhpr PE=1 SV=1 PF03446//PF00899//PF02826//PF00389 NAD binding domain of 6-phosphogluconate dehydrogenase//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0055114//GO:0019521//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//metabolic process//pentose-phosphate shunt GO:0048037//GO:0008641//GO:0004616//GO:0000166//GO:0051287//GO:0016616 cofactor binding//small protein activating enzyme activity//phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.32811 BP_3 548.95 32.82 1098 642913868 XP_008201196.1 827 9.0e-86 PREDICTED: leucine-rich repeat-containing protein C10orf11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D9B4 539 9.2e-54 Leucine-rich repeat-containing protein C10orf11 homolog OS=Mus musculus PE=2 SV=1 PF02963//PF13855//PF05955//PF00560 Restriction endonuclease EcoRI//Leucine rich repeat//Equine herpesvirus glycoprotein gp2//Leucine Rich Repeat GO:0006308//GO:0009307//GO:0016032 DNA catabolic process//DNA restriction-modification system//viral process GO:0000287//GO:0005515//GO:0003677//GO:0009036 magnesium ion binding//protein binding//DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359//GO:0016021 Type II site-specific deoxyribonuclease complex//integral component of membrane KOG1644 U2-associated snRNP A' protein Cluster-8309.32812 BP_3 764.11 7.05 5514 91092090 XP_971602.1 1246 1.2e-133 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 Q0P678 341 4.2e-30 Zinc finger CCCH domain-containing protein 18 OS=Mus musculus GN=Zc3h18 PE=1 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- -- -- Cluster-8309.32814 BP_3 27.62 1.01 1613 478249963 ENN70470.1 498 1.9e-47 hypothetical protein YQE_12973, partial [Dendroctonus ponderosae] -- -- -- -- -- K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q9H000 401 1.4e-37 Probable E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens GN=MKRN2 PE=1 SV=2 PF14634//PF08152//PF15332//PF17123//PF12678//PF00097//PF13639//PF12861//PF00642 zinc-RING finger domain//GUCT (NUC152) domain//Lck-interacting transmembrane adapter 1//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0050853//GO:0050852//GO:0016567 B cell receptor signaling pathway//T cell receptor signaling pathway//protein ubiquitination GO:0008270//GO:0046872//GO:0005524//GO:0003723//GO:0004386//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ATP binding//RNA binding//helicase activity//ubiquitin-protein transferase activity//protein binding GO:0005634//GO:0005680 nucleus//anaphase-promoting complex -- -- Cluster-8309.32817 BP_3 326.00 10.16 1839 642935974 XP_008198253.1 1686 3.8e-185 PREDICTED: inositol-trisphosphate 3-kinase A isoform X2 [Tribolium castaneum]>gi|270013997|gb|EFA10445.1| hypothetical protein TcasGA2_TC012691 [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P17105 586 5.5e-59 Inositol-trisphosphate 3-kinase A OS=Rattus norvegicus GN=Itpka PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.32818 BP_3 16.34 0.31 2873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32819 BP_3 1184.31 30.15 2185 642918045 XP_008198993.1 696 2.8e-70 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9B9 423 5.2e-40 Choline transporter-like protein 1 OS=Torpedo marmorata GN=slc44a1 PE=1 SV=1 PF05786//PF06350 Condensin complex subunit 2//Hormone-sensitive lipase (HSL) N-terminus GO:0016042//GO:0007076//GO:0008203 lipid catabolic process//mitotic chromosome condensation//cholesterol metabolic process GO:0016298 lipase activity GO:0000796 condensin complex KOG1362 Choline transporter-like protein Cluster-8309.32823 BP_3 16.00 1.68 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32824 BP_3 18.99 0.36 2814 642919248 XP_008191793.1 772 5.5e-79 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|642919250|ref|XP_008191794.1| PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|270005765|gb|EFA02213.1| hypothetical protein TcasGA2_TC007872 [Tribolium castaneum] 170068618 XM_001868902.1 84 2.56723e-33 Culex quinquefasciatus cation efflux protein/ zinc transporter, mRNA K14688 SLC30A1, ZNT1 solute carrier family 30 (zinc transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14688 P20107 302 7.2e-26 Zinc/cadmium resistance protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZRC1 PE=1 SV=2 PF01545//PF03741 Cation efflux family//Integral membrane protein TerC family GO:0006812//GO:0044765//GO:0055085 cation transport//single-organism transport//transmembrane transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.32826 BP_3 75.00 4.59 1080 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32828 BP_3 45.56 1.08 2321 642919704 XP_008192030.1 434 7.1e-40 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15925 SOSS complex subunit C GO:0006974//GO:0006281 cellular response to DNA damage stimulus//DNA repair GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0005634//GO:0070876 nucleus//SOSS complex -- -- Cluster-8309.32829 BP_3 1846.91 34.99 2836 91081249 XP_975650.1 638 1.9e-63 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q5ZKN2 387 1.0e-35 Membrane-associated progesterone receptor component 1 OS=Gallus gallus GN=PGRMC1 PE=2 SV=3 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.32830 BP_3 359.93 5.20 3629 755951729 XP_011301857.1 550 3.9e-53 PREDICTED: guanine nucleotide-binding protein subunit beta-like protein isoform X2 [Fopius arisanus] -- -- -- -- -- K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 502 6.0e-49 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.32835 BP_3 180.65 2.54 3722 642939572 XP_008200536.1 588 1.6e-57 PREDICTED: uncharacterized protein LOC103314960 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32836 BP_3 1304.34 47.51 1615 91085165 XP_970735.1 1533 1.8e-167 PREDICTED: septin-1 [Tribolium castaneum]>gi|270008471|gb|EFA04919.1| hypothetical protein TcasGA2_TC014984 [Tribolium castaneum] 213514885 NM_001140440.1 121 3.94765e-54 Salmo salar septin 2 (sept2), mRNA >gnl|BL_ORD_ID|5992956 Salmo salar clone ssal-rgf-535-071 Septin-2 putative mRNA, complete cds K16942 SEPT2 septin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16942 P42207 1401 1.5e-153 Septin-1 OS=Drosophila melanogaster GN=Sep1 PE=1 SV=1 PF00005//PF03193//PF04670//PF01580//PF04548//PF00071//PF08477//PF00735//PF01926//PF05049 ABC transporter//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//FtsK/SpoIIIE family//AIG1 family//Ras family//Ras of Complex, Roc, domain of DAPkinase//Septin//50S ribosome-binding GTPase//Interferon-inducible GTPase (IIGP) GO:0007264//GO:0007049 small GTPase mediated signal transduction//cell cycle GO:0005525//GO:0000166//GO:0016887//GO:0003924//GO:0005524//GO:0003677 GTP binding//nucleotide binding//ATPase activity//GTPase activity//ATP binding//DNA binding GO:0031105//GO:0016020 septin complex//membrane -- -- Cluster-8309.32838 BP_3 3.00 1.46 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32839 BP_3 42.03 1.00 2315 91083675 XP_968367.1 1831 7.3e-202 PREDICTED: serine/threonine-protein kinase PINK1, mitochondrial [Tribolium castaneum]>gi|270006820|gb|EFA03268.1| hypothetical protein TcasGA2_TC013202 [Tribolium castaneum] -- -- -- -- -- K05688 PINK1 PTEN induced putative kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05688 Q9BXM7 729 1.8e-75 Serine/threonine-protein kinase PINK1, mitochondrial OS=Homo sapiens GN=PINK1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG4158 BRPK/PTEN-induced protein kinase Cluster-8309.32841 BP_3 76.09 0.47 8174 641658099 XP_008180596.1 929 1.0e-96 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 642920823 XM_008194352.1 69 1.63875e-24 PREDICTED: Tribolium castaneum transcription factor SPT20 homolog (LOC661459), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 867 6.4e-91 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00096//PF12833//PF04810//PF02892//PF13912//PF12090//PF16622//PF13465 Zinc finger, C2H2 type//Helix-turn-helix domain//Sec23/Sec24 zinc finger//BED zinc finger//C2H2-type zinc finger//Spt20 family//zinc-finger C2H2-type//Zinc-finger double domain GO:0006355//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0003700//GO:0046872//GO:0008270//GO:0043565//GO:0003712//GO:0003677 transcription factor activity, sequence-specific DNA binding//metal ion binding//zinc ion binding//sequence-specific DNA binding//transcription cofactor activity//DNA binding GO:0000124//GO:0005667//GO:0030127 SAGA complex//transcription factor complex//COPII vesicle coat -- -- Cluster-8309.32843 BP_3 1021.18 70.49 990 642931867 XP_008196761.1 474 7.0e-45 PREDICTED: 46 kDa FK506-binding nuclear protein [Tribolium castaneum]>gi|270011711|gb|EFA08159.1| hypothetical protein TcasGA2_TC005779 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q26486 441 1.9e-42 46 kDa FK506-binding nuclear protein OS=Spodoptera frugiperda GN=FKBP46 PE=2 SV=1 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase GO:0000412//GO:0006457 histone peptidyl-prolyl isomerization//protein folding GO:0005528//GO:0003755 FK506 binding//peptidyl-prolyl cis-trans isomerase activity GO:0005730 nucleolus KOG0552 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.32844 BP_3 401.72 10.58 2121 91089541 XP_971419.1 818 1.9e-84 PREDICTED: protein canopy 4 [Tribolium castaneum]>gi|270012595|gb|EFA09043.1| hypothetical protein TcasGA2_TC006756 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2L6K8 520 2.9e-51 Protein canopy 4 OS=Danio rerio GN=cnpy4 PE=2 SV=1 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- KOG4052 Uncharacterized conserved protein Cluster-8309.32845 BP_3 547.73 9.40 3101 751797551 XP_011208646.1 373 1.1e-32 PREDICTED: 39 kDa FK506-binding nuclear protein [Bactrocera dorsalis] -- -- -- -- -- K14826 FPR3_4 FK506-binding nuclear protein http://www.genome.jp/dbget-bin/www_bget?ko:K14826 Q26486 368 1.8e-33 46 kDa FK506-binding nuclear protein OS=Spodoptera frugiperda GN=FKBP46 PE=2 SV=1 PF08052//PF00254 PyrBI operon leader peptide//FKBP-type peptidyl-prolyl cis-trans isomerase GO:0019856//GO:0006457 pyrimidine nucleobase biosynthetic process//protein folding -- -- -- -- KOG0552 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.32846 BP_3 1464.50 12.68 5859 642914541 XP_008201720.1 2081 1.9e-230 PREDICTED: organic cation transporter protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 857 6.6e-90 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083//PF04847 Major Facilitator Superfamily//Sugar (and other) transporter//Calcipressin GO:0055085//GO:0019722 transmembrane transport//calcium-mediated signaling GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.32847 BP_3 243.59 13.57 1157 91093175 XP_968014.1 866 2.9e-90 PREDICTED: ankyrin repeat domain-containing protein 29 [Tribolium castaneum]>gi|270012951|gb|EFA09399.1| hypothetical protein TcasGA2_TC004317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502M6 439 3.8e-42 Ankyrin repeat domain-containing protein 29 OS=Danio rerio GN=ankrd29 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32848 BP_3 33.00 5.55 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32849 BP_3 62.09 0.98 3331 91093162 XP_967461.1 1758 3.0e-193 PREDICTED: nucleolar complex protein 4 homolog B [Tribolium castaneum]>gi|270012948|gb|EFA09396.1| hypothetical protein TcasGA2_TC004314 [Tribolium castaneum] -- -- -- -- -- K14771 NOC4, UTP19 U3 small nucleolar RNA-associated protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K14771 Q6NRQ2 650 3.8e-66 Nucleolar complex protein 4 homolog A OS=Xenopus laevis GN=noc4l-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2154 Predicted nucleolar protein involved in ribosome biogenesis Cluster-8309.32851 BP_3 1546.00 28.86 2874 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08127 Peptidase family C1 propeptide GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.32852 BP_3 977.15 37.11 1561 189235436 XP_001812776.1 872 7.8e-91 PREDICTED: protein twisted gastrulation [Tribolium castaneum]>gi|270004290|gb|EFA00738.1| hypothetical protein TcasGA2_TC003620 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54356 495 1.7e-48 Protein twisted gastrulation OS=Drosophila melanogaster GN=tsg PE=1 SV=1 PF03627 PapG carbohydrate binding domain GO:0007155 cell adhesion GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.32854 BP_3 13.04 0.99 924 478262344 ENN81050.1 347 3.5e-30 hypothetical protein YQE_02544, partial [Dendroctonus ponderosae]>gi|546686568|gb|ERL95746.1| hypothetical protein D910_00204 [Dendroctonus ponderosae]>gi|546687019|gb|ERL95951.1| hypothetical protein D910_00665 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P2X9 154 3.4e-09 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32855 BP_3 1688.03 36.08 2547 189234663 XP_969172.2 1961 6.7e-217 PREDICTED: monocarboxylate transporter 10 [Tribolium castaneum]>gi|642914047|ref|XP_008201523.1| PREDICTED: monocarboxylate transporter 10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K1C7 300 1.1e-25 Monocarboxylate transporter 14 OS=Mus musculus GN=Slc16a14 PE=2 SV=1 PF02308//PF07690 MgtC family//Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.32856 BP_3 268.07 18.22 1001 91090398 XP_970402.1 897 6.3e-94 PREDICTED: mediator of RNA polymerase II transcription subunit 19 [Tribolium castaneum]>gi|270013384|gb|EFA09832.1| hypothetical protein TcasGA2_TC011979 [Tribolium castaneum] 665785746 XM_008550626.1 219 8.04164e-109 PREDICTED: Microplitis demolitor mediator of RNA polymerase II transcription subunit 19 (LOC103572159), mRNA K15137 MED19 mediator of RNA polymerase II transcription subunit 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15137 Q174D3 697 4.0e-72 Mediator of RNA polymerase II transcription subunit 19 OS=Aedes aegypti GN=MED19 PE=3 SV=1 PF06459//PF10278//PF02932 Ryanodine Receptor TM 4-6//Mediator of RNA pol II transcription subunit 19//Neurotransmitter-gated ion-channel transmembrane region GO:0006357//GO:0006874//GO:0006811//GO:0006816 regulation of transcription from RNA polymerase II promoter//cellular calcium ion homeostasis//ion transport//calcium ion transport GO:0001104//GO:0005219 RNA polymerase II transcription cofactor activity//ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016020//GO:0016592//GO:0016021 intracellular//membrane//mediator complex//integral component of membrane -- -- Cluster-8309.32857 BP_3 264.56 1.83 7257 91076984 XP_975463.1 1357 2.1e-146 PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913260|ref|XP_008201461.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913262|ref|XP_008201462.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|270001993|gb|EEZ98440.1| hypothetical protein TcasGA2_TC000929 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97379 370 2.4e-33 Ras GTPase-activating protein-binding protein 2 OS=Mus musculus GN=G3bp2 PE=1 SV=2 PF02136//PF16367//PF15886//PF00076 Nuclear transport factor 2 (NTF2) domain//RNA recognition motif//Carbohydrate binding domain (family 32)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006810 transport GO:0030246//GO:0003676 carbohydrate binding//nucleic acid binding GO:0005622 intracellular KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains Cluster-8309.32865 BP_3 132.34 6.36 1294 642924152 XP_008194029.1 432 6.8e-40 PREDICTED: endothelin-converting enzyme-like 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.32866 BP_3 117.70 4.02 1702 134131322 BAF49604.1 483 1.1e-45 chitinase [Monochamus alternatus] -- -- -- -- -- K17523 CHI3L1_2 chitinase-3-like protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17523 P36362 245 1.8e-19 Endochitinase OS=Manduca sexta PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.32867 BP_3 95.86 2.90 1886 170321839 BAG14264.1 714 2.0e-72 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8CFG8 240 7.5e-19 Complement C1s-B subcomponent OS=Mus musculus GN=C1sb PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32869 BP_3 24.39 0.44 2991 642924917 XP_008194096.1 3268 0.0e+00 PREDICTED: neprilysin-2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08635 MMEL1 membrane metallo-endopeptidase-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08635 O16796 1289 2.7e-140 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.3287 BP_3 13.00 0.40 1863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32870 BP_3 1131.14 17.96 3328 282720985 NP_001164243.1 2817 0.0e+00 angiotensin-converting enzyme 3 precursor [Tribolium castaneum]>gi|270015941|gb|EFA12389.1| Ance-3 [Tribolium castaneum] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 1438 1.6e-157 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.32873 BP_3 78.00 1.33 3129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32874 BP_3 42.27 0.33 6546 91082437 XP_970911.1 820 3.5e-84 PREDICTED: tribbles homolog 2 [Tribolium castaneum] 645019257 XM_001600513.3 42 1.339e-09 PREDICTED: Nasonia vitripennis tribbles homolog 2-like (LOC100115993), mRNA K08814 TRIB1_2 tribbles homolog 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08814 Q5R669 460 8.0e-44 Tribbles homolog 2 OS=Pongo abelii GN=TRIB2 PE=2 SV=1 PF00069//PF07714//PF08755//PF03283//PF00539 Protein kinase domain//Protein tyrosine kinase//Hemimethylated DNA-binding protein YccV like//Pectinacetylesterase//Transactivating regulatory protein (Tat) GO:0006468//GO:0006355 protein phosphorylation//regulation of transcription, DNA-templated GO:0005524//GO:0016787//GO:0003677//GO:0003700//GO:0004672 ATP binding//hydrolase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//protein kinase activity GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG0583 Serine/threonine protein kinase Cluster-8309.32876 BP_3 931.00 10.88 4415 91076474 XP_972312.1 5444 0.0e+00 PREDICTED: protein toll [Tribolium castaneum]>gi|270002908|gb|EEZ99355.1| toll-7-like protein [Tribolium castaneum] 642912519 XM_967219.2 872 0 PREDICTED: Tribolium castaneum toll-7-like protein (LOC661030), mRNA -- -- -- -- O75094 449 1.0e-42 Slit homolog 3 protein OS=Homo sapiens GN=SLIT3 PE=2 SV=3 PF13855//PF01582//PF00560//PF13676 Leucine rich repeat//TIR domain//Leucine Rich Repeat//TIR domain GO:0007165 signal transduction GO:0005515 protein binding GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.32877 BP_3 129.45 6.18 1301 642932482 XP_008197132.1 902 2.2e-94 PREDICTED: nucleoside diphosphate-linked moiety X motif 6 isoform X2 [Tribolium castaneum]>gi|642932484|ref|XP_008197133.1| PREDICTED: nucleoside diphosphate-linked moiety X motif 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8L7W2 380 3.0e-35 Nudix hydrolase 8 OS=Arabidopsis thaliana GN=NUDT8 PE=2 SV=2 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG0648 Predicted NUDIX hydrolase FGF-2 and related proteins Cluster-8309.32878 BP_3 19.85 0.79 1506 642932480 XP_973309.2 914 1.0e-95 PREDICTED: nudix hydrolase 8 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8L7W2 380 3.5e-35 Nudix hydrolase 8 OS=Arabidopsis thaliana GN=NUDT8 PE=2 SV=2 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG0648 Predicted NUDIX hydrolase FGF-2 and related proteins Cluster-8309.3288 BP_3 1.00 3.59 274 16903179 AAK61417.1 209 1.0e-14 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32880 BP_3 31.19 0.55 3028 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09003 Bacteriophage lambda integrase, N-terminal domain GO:0015074 DNA integration GO:0003677//GO:0008907 DNA binding//integrase activity -- -- -- -- Cluster-8309.32884 BP_3 1990.10 27.37 3796 642911078 XP_008200566.1 2414 3.0e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 3.4e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF13442//PF01585//PF07808//PF00641//PF00076//PF11648 Cytochrome C oxidase, cbb3-type, subunit III//G-patch domain//RED-like protein N-terminal region//Zn-finger in Ran binding protein and others//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C-terminal domain of RIG-I GO:0006118 obsolete electron transport GO:0020037//GO:0016817//GO:0008270//GO:0000166//GO:0009055//GO:0003676 heme binding//hydrolase activity, acting on acid anhydrides//zinc ion binding//nucleotide binding//electron carrier activity//nucleic acid binding GO:0005622//GO:0005634 intracellular//nucleus KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.32885 BP_3 340.05 5.20 3443 546672307 ERL84230.1 1819 2.7e-200 hypothetical protein D910_01607 [Dendroctonus ponderosae]>gi|546672574|gb|ERL84383.1| hypothetical protein D910_01813 [Dendroctonus ponderosae] 642933834 XM_008192574.1 146 1.07769e-67 PREDICTED: Tribolium castaneum leucine-rich repeat-containing protein let-4 (LOC659033), mRNA -- -- -- -- Q8R5M3 339 4.5e-30 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF00322//PF00560//PF13855 Endothelin family//Leucine Rich Repeat//Leucine rich repeat GO:0019229 regulation of vasoconstriction GO:0005515 protein binding GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.32887 BP_3 963.96 12.94 3881 642931167 XP_969130.2 3383 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 31 [Tribolium castaneum] 194757190 XM_001960812.1 46 4.72837e-12 Drosophila ananassae GF13568 (Dana\GF13568), mRNA K11852 USP31 ubiquitin carboxyl-terminal hydrolase 31 http://www.genome.jp/dbget-bin/www_bget?ko:K11852 Q8BUM9 1056 3.7e-113 Ubiquitin carboxyl-terminal hydrolase 43 OS=Mus musculus GN=Usp43 PE=2 SV=2 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.32888 BP_3 106.04 1.23 4439 642931167 XP_969130.2 3325 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 31 [Tribolium castaneum] 194757190 XM_001960812.1 46 5.41457e-12 Drosophila ananassae GF13568 (Dana\GF13568), mRNA K11852 USP31 ubiquitin carboxyl-terminal hydrolase 31 http://www.genome.jp/dbget-bin/www_bget?ko:K11852 Q8BUM9 1044 1.0e-111 Ubiquitin carboxyl-terminal hydrolase 43 OS=Mus musculus GN=Usp43 PE=2 SV=2 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.32890 BP_3 16.14 0.45 2010 642936612 XP_008198506.1 556 4.4e-54 PREDICTED: uncharacterized protein LOC661523 isoform X2 [Tribolium castaneum]>gi|270013067|gb|EFA09515.1| hypothetical protein TcasGA2_TC011617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32891 BP_3 623.85 18.88 1884 642926542 XP_008194914.1 1316 3.1e-142 PREDICTED: LOW QUALITY PROTEIN: arginine-glutamic acid dipeptide repeats protein [Tribolium castaneum] 766941684 XM_011505186.1 56 6.27942e-18 PREDICTED: Ceratosolen solmsi marchali arginine-glutamic acid dipeptide repeats protein (LOC105366667), mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q80TZ9 151 1.6e-08 Arginine-glutamic acid dipeptide repeats protein OS=Mus musculus GN=Rere PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32892 BP_3 181.00 8.11 1367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32893 BP_3 67.33 1.90 2001 642926542 XP_008194914.1 1288 5.8e-139 PREDICTED: LOW QUALITY PROTEIN: arginine-glutamic acid dipeptide repeats protein [Tribolium castaneum] 766941684 XM_011505186.1 56 6.67676e-18 PREDICTED: Ceratosolen solmsi marchali arginine-glutamic acid dipeptide repeats protein (LOC105366667), mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q80TZ9 151 1.7e-08 Arginine-glutamic acid dipeptide repeats protein OS=Mus musculus GN=Rere PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32895 BP_3 850.00 17.97 2571 478253235 ENN73606.1 1674 1.3e-183 hypothetical protein YQE_09853, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SSM3 743 4.8e-77 Rho GTPase-activating protein 44 OS=Mus musculus GN=Arhgap44 PE=1 SV=1 PF03114//PF00620 BAR domain//RhoGAP domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005737 cytoplasm KOG4270 GTPase-activator protein Cluster-8309.32897 BP_3 86.00 10.41 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32898 BP_3 115.45 1.25 4745 642922405 XP_008193143.1 994 1.7e-104 PREDICTED: tetratricopeptide repeat protein 14 isoform X2 [Tribolium castaneum] 642922404 XM_008194921.1 225 1.80798e-111 PREDICTED: Tribolium castaneum tetratricopeptide repeat protein 14 (LOC663177), transcript variant X2, mRNA -- -- -- -- Q9VGU5 596 9.8e-60 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF01080//PF13181//PF13174//PF05053//PF11744//PF15741//PF13371//PF09726//PF02724//PF13374//PF00515//PF13414//PF13176//PF10486 Presenilin//Tetratricopeptide repeat//Tetratricopeptide repeat//Menin//Aluminium activated malate transporter//Ligand-dependent nuclear receptor-interacting factor 1//Tetratricopeptide repeat//Transmembrane protein//CDC45-like protein//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Phosphoinositide 3-kinase gamma adapter protein p101 subunit GO:0006355//GO:0015743//GO:0006270//GO:0007165 regulation of transcription, DNA-templated//malate transport//DNA replication initiation//signal transduction GO:0046935//GO:0042974//GO:0005515//GO:0004190 1-phosphatidylinositol-3-kinase regulator activity//retinoic acid receptor binding//protein binding//aspartic-type endopeptidase activity GO:0005944//GO:0005667//GO:0005634//GO:0016021 phosphatidylinositol 3-kinase complex, class IB//transcription factor complex//nucleus//integral component of membrane -- -- Cluster-8309.32899 BP_3 5402.21 37.80 7180 546676276 ERL87322.1 1518 4.4e-165 hypothetical protein D910_04717 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGU5 692 1.1e-70 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF13414//PF13176//PF08515//PF07688//PF13371//PF03145//PF13374//PF00515//PF13174//PF13181 TPR repeat//Tetratricopeptide repeat//Transforming growth factor beta type I GS-motif//KaiA domain//Tetratricopeptide repeat//Seven in absentia protein family//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0016310//GO:0006468//GO:0009069//GO:0007623//GO:0007275//GO:0007178//GO:0006511 phosphorylation//protein phosphorylation//serine family amino acid metabolic process//circadian rhythm//multicellular organismal development//transmembrane receptor protein serine/threonine kinase signaling pathway//ubiquitin-dependent protein catabolic process GO:0005515//GO:0005524//GO:0004675 protein binding//ATP binding//transmembrane receptor protein serine/threonine kinase activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.32900 BP_3 626.54 11.76 2860 91092242 XP_971366.1 2149 1.2e-238 PREDICTED: protein ariadne-2 [Tribolium castaneum]>gi|270014427|gb|EFA10875.1| hypothetical protein TcasGA2_TC001697 [Tribolium castaneum] 462373241 APGK01024814.1 200 8.56154e-98 Dendroctonus ponderosae Seq01024824, whole genome shotgun sequence K11969 ARIH2 ariadne-2 http://www.genome.jp/dbget-bin/www_bget?ko:K11969 O76924 1831 3.7e-203 Protein ariadne-2 OS=Drosophila melanogaster GN=ari-2 PE=2 SV=1 PF00097//PF14634//PF09749//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Uncharacterised conserved protein//Ring finger domain GO:0034477 U6 snRNA 3'-end processing GO:0004518//GO:0005515//GO:0046872//GO:0008270 nuclease activity//protein binding//metal ion binding//zinc ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.32903 BP_3 486.72 10.76 2473 546680452 ERL90718.1 1948 2.1e-215 hypothetical protein D910_08065 [Dendroctonus ponderosae] -- -- -- -- -- K11854 USP35_38 ubiquitin carboxyl-terminal hydrolase 35/38 http://www.genome.jp/dbget-bin/www_bget?ko:K11854 Q8NB14 527 5.1e-52 Ubiquitin carboxyl-terminal hydrolase 38 OS=Homo sapiens GN=USP38 PE=1 SV=2 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.32904 BP_3 26.15 2.10 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32905 BP_3 1617.91 7.56 10602 817185266 XP_012285919.1 6615 0.0e+00 PREDICTED: neurobeachin isoform X10 [Orussus abietinus] 642919353 XM_008193614.1 1061 0 PREDICTED: Tribolium castaneum neurobeachin (LOC662147), transcript variant X2, mRNA -- -- -- -- Q9W4E2 4768 0.0e+00 Neurobeachin OS=Drosophila melanogaster GN=rg PE=1 SV=3 PF07127//PF10508//PF00400//PF15088 Late nodulin protein//Proteasome non-ATPase 26S subunit//WD domain, G-beta repeat//NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial GO:0009878//GO:0043248 nodule morphogenesis//proteasome assembly GO:0046872//GO:0005515 metal ion binding//protein binding GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.32907 BP_3 1420.01 6.81 10339 189238427 XP_973569.2 3930 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase DHX34 [Tribolium castaneum]>gi|270008523|gb|EFA04971.1| hypothetical protein TcasGA2_TC015049 [Tribolium castaneum] 642925354 XM_008196294.1 497 0 PREDICTED: Tribolium castaneum integrator complex subunit 2 (LOC661595), mRNA K13139 INTS2 integrator complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13139 Q14147 2048 9.2e-228 Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens GN=DHX34 PE=1 SV=2 PF00023//PF04851//PF03391//PF07527//PF14750//PF00270//PF04857//PF04408//PF13606//PF02399 Ankyrin repeat//Type III restriction enzyme, res subunit//Nepovirus coat protein, central domain//Hairy Orange//Integrator complex subunit 2//DEAD/DEAH box helicase//CAF1 family ribonuclease//Helicase associated domain (HA2)//Ankyrin repeat//Origin of replication binding protein GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003676//GO:0005515//GO:0008026//GO:0005198//GO:0016787//GO:0003677//GO:0003688//GO:0004386//GO:0005524 nucleic acid binding//protein binding//ATP-dependent helicase activity//structural molecule activity//hydrolase activity//DNA binding//DNA replication origin binding//helicase activity//ATP binding GO:0046809//GO:0032039//GO:0005634//GO:0019028 replication compartment//integrator complex//nucleus//viral capsid KOG4177 Ankyrin Cluster-8309.32908 BP_3 84.56 0.40 10533 817185266 XP_012285919.1 6615 0.0e+00 PREDICTED: neurobeachin isoform X10 [Orussus abietinus] 642919353 XM_008193614.1 1061 0 PREDICTED: Tribolium castaneum neurobeachin (LOC662147), transcript variant X2, mRNA -- -- -- -- Q9W4E2 4768 0.0e+00 Neurobeachin OS=Drosophila melanogaster GN=rg PE=1 SV=3 PF15088//PF07127//PF10508//PF00400 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial//Late nodulin protein//Proteasome non-ATPase 26S subunit//WD domain, G-beta repeat GO:0043248//GO:0009878 proteasome assembly//nodule morphogenesis GO:0005515//GO:0046872 protein binding//metal ion binding GO:0005747//GO:0005739 mitochondrial respiratory chain complex I//mitochondrion KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.32910 BP_3 456.35 4.89 4787 642913783 XP_008201159.1 1925 1.9e-212 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 1.59033e-27 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 1739 2.9e-192 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF04750//PF01562//PF10462//PF00413 FAR-17a/AIG1-like protein//Reprolysin family propeptide//Peptidase M66//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0016021//GO:0031012 integral component of membrane//extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.32911 BP_3 3237.44 204.98 1053 478252267 ENN72695.1 178 1.6e-10 hypothetical protein YQE_10790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V7U0 155 3.0e-09 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32912 BP_3 546.24 5.94 4726 478252002 ENN72437.1 1353 4.0e-146 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 143 6.90217e-66 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 919 3.4e-97 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF00098//PF13014//PF00013//PF08273 Zinc knuckle//KH domain//KH domain//Zinc-binding domain of primase-helicase GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896//GO:0004386//GO:0003723//GO:0003676//GO:0008270 DNA primase activity//helicase activity//RNA binding//nucleic acid binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.32913 BP_3 1376.96 47.98 1675 478252002 ENN72437.1 1609 2.9e-176 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 143 2.41431e-66 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 1084 9.0e-117 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF13014//PF00098//PF08273//PF00013 KH domain//Zinc knuckle//Zinc-binding domain of primase-helicase//KH domain GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896//GO:0003723//GO:0004386//GO:0003676//GO:0008270 DNA primase activity//RNA binding//helicase activity//nucleic acid binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.32915 BP_3 142.27 1.77 4175 642916479 XP_008191061.1 1715 3.7e-188 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TUF1 1179 2.2e-127 Serrate RNA effector molecule homolog OS=Anopheles gambiae GN=Ars2 PE=3 SV=3 PF09726//PF00076 Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding GO:0016021 integral component of membrane KOG2295 C2H2 Zn-finger protein Cluster-8309.32916 BP_3 70.05 0.88 4148 642916479 XP_008191061.1 1579 2.2e-172 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17FR9 1136 2.1e-122 Serrate RNA effector molecule homolog OS=Aedes aegypti GN=Ars2 PE=3 SV=1 PF00076//PF09726 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG2295 C2H2 Zn-finger protein Cluster-8309.32923 BP_3 801.28 34.94 1397 761901546 XP_011404925.1 340 3.4e-29 PREDICTED: uncharacterized protein LOC100639010 [Amphimedon queenslandica] -- -- -- -- -- -- -- -- -- Q1RK13 304 2.1e-26 Putative ankyrin repeat protein RBE_0220 OS=Rickettsia bellii (strain RML369-C) GN=RBE_0220 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32924 BP_3 1926.19 34.82 2958 91077984 XP_968658.1 1421 3.2e-154 PREDICTED: serine protease 42 [Tribolium castaneum]>gi|270002734|gb|EEZ99181.1| serine protease H2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 440 7.5e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.32925 BP_3 506.42 13.48 2103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32929 BP_3 15.03 0.44 1939 755929777 XP_011311847.1 286 8.6e-23 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Fopius arisanus] -- -- -- -- -- K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 Q3T0R7 237 1.7e-18 3-ketoacyl-CoA thiolase, mitochondrial OS=Bos taurus GN=ACAA2 PE=2 SV=1 PF02803 Thiolase, C-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1391 Acetyl-CoA acetyltransferase Cluster-8309.3293 BP_3 3.00 0.54 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32930 BP_3 109.33 0.50 10855 642911435 XP_008199422.1 2576 1.4e-287 PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911437|ref|XP_008199423.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911439|ref|XP_008199424.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum] -- -- -- -- -- K01349 FURIN, PCSK3 furin http://www.genome.jp/dbget-bin/www_bget?ko:K01349 P30430 1965 4.1e-218 Furin-like protease 1, isoform 1-CRR OS=Drosophila melanogaster GN=Fur1 PE=2 SV=2 PF00082//PF08496//PF01483//PF09458 Subtilase family//Peptidase family S49 N-terminal//Proprotein convertase P-domain//H-type lectin domain GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252//GO:0030246 serine-type endopeptidase activity//carbohydrate binding GO:0005886 plasma membrane KOG3525 Subtilisin-like proprotein convertase Cluster-8309.32931 BP_3 267.13 9.22 1688 642913141 XP_008201410.1 1406 1.0e-152 PREDICTED: C-5 sterol desaturase erg31-like [Tribolium castaneum] -- -- -- -- -- K00227 SC5DL, ERG3 delta7-sterol 5-desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K00227 Q7SBB6 242 3.9e-19 Probable C-5 sterol desaturase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=NCU06207 PE=3 SV=1 PF03419//PF04116 Sporulation factor SpoIIGA//Fatty acid hydroxylase superfamily GO:0055114//GO:0006508//GO:0030436//GO:0006633 oxidation-reduction process//proteolysis//asexual sporulation//fatty acid biosynthetic process GO:0016491//GO:0005506//GO:0004190 oxidoreductase activity//iron ion binding//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.32933 BP_3 34.94 0.36 4934 546678918 ERL89456.1 268 2.7e-20 hypothetical protein D910_06823 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 155 1.4e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF00643 Zinc finger, C2H2 type//Zinc-finger double domain//B-box zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.32935 BP_3 517.30 25.10 1285 134131322 BAF49604.1 829 6.2e-86 chitinase [Monochamus alternatus] -- -- -- -- -- -- -- -- -- P36362 460 1.6e-44 Endochitinase OS=Manduca sexta PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.32936 BP_3 3.00 5.79 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32937 BP_3 96.00 6.87 965 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83652 196 4.8e-14 Antimicrobial peptide Alo-2 OS=Acrocinus longimanus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32938 BP_3 3.65 0.88 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32939 BP_3 27.59 0.50 2933 478256793 ENN76971.1 289 5.9e-23 hypothetical protein YQE_06539, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32941 BP_3 38.91 9.08 498 38114661 AAH08955.2 233 3.1e-17 UBC protein, partial [Homo sapiens] 168028715 XM_001766821.1 87 9.24492e-36 Physcomitrella patens subsp. patens predicted protein (PHYPADRAFT_80683) mRNA, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 219 5.4e-17 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.32942 BP_3 290.02 9.49 1765 642928919 XP_008195616.1 1705 2.3e-187 PREDICTED: beclin-1-like protein [Tribolium castaneum] 831317244 XM_012835846.1 40 4.60659e-09 PREDICTED: Clupea harengus beclin 1, autophagy related (becn1), transcript variant X2, mRNA K08334 BECN1, VPS30, ATG6 beclin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08334 Q9VCE1 1285 4.7e-140 Beclin-1-like protein OS=Drosophila melanogaster GN=Atg6 PE=2 SV=1 PF04111//PF07851//PF04420 Autophagy protein Apg6//TMPIT-like protein//CHD5-like protein GO:0006914//GO:0071816 autophagy//tail-anchored membrane protein insertion into ER membrane -- -- GO:0016021 integral component of membrane KOG2751 Beclin-like protein Cluster-8309.32944 BP_3 59.65 0.44 6838 642936990 XP_008198645.1 1443 2.1e-156 PREDICTED: gamma-glutamyltransferase 7-like [Tribolium castaneum]>gi|642936992|ref|XP_008198647.1| PREDICTED: gamma-glutamyltransferase 7-like [Tribolium castaneum]>gi|270001032|gb|EEZ97479.1| hypothetical protein TcasGA2_TC011313 [Tribolium castaneum] 642939072 XM_008201989.1 129 6.06466e-58 PREDICTED: Tribolium castaneum DEAD-box ATP-dependent RNA helicase 20-like (LOC103312134), transcript variant X2, mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 841 5.5e-88 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF01019//PF04851//PF00270 Gamma-glutamyltranspeptidase//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0006693//GO:0006691//GO:0006749//GO:0019530 prostaglandin metabolic process//leukotriene metabolic process//glutathione metabolic process//taurine metabolic process GO:0003676//GO:0003840//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//gamma-glutamyltransferase activity//hydrolase activity//DNA binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.32945 BP_3 25.00 0.59 2323 642917850 XP_008191312.1 286 1.0e-22 PREDICTED: serine/threonine-protein kinase MARK2 isoform X10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32946 BP_3 60.34 0.65 4781 270013073 EFA09521.1 1113 2.7e-118 hypothetical protein TcasGA2_TC011623 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 Q5SWT3 770 6.6e-80 Solute carrier family 25 member 35 OS=Mus musculus GN=Slc25a35 PE=2 SV=2 PF00069//PF01674//PF07714 Protein kinase domain//Lipase (class 2)//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016787//GO:0004672 ATP binding//hydrolase activity//protein kinase activity -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.32947 BP_3 2800.00 35.22 4124 820805532 AKG92757.1 3460 0.0e+00 helix loop helix protein 106 [Leptinotarsa decemlineata] -- -- -- -- -- K07197 SREBP1, SREBF1 sterol regulatory element-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07197 Q60416 1235 6.9e-134 Sterol regulatory element-binding protein 1 OS=Cricetulus griseus GN=SREBF1 PE=2 SV=1 PF00010//PF15898//PF01166 Helix-loop-helix DNA-binding domain//cGMP-dependent protein kinase interacting domain//TSC-22/dip/bun family GO:0006355 regulation of transcription, DNA-templated GO:0019901//GO:0003700//GO:0046983 protein kinase binding//transcription factor activity, sequence-specific DNA binding//protein dimerization activity GO:0005667 transcription factor complex KOG2588 Predicted DNA-binding protein Cluster-8309.32950 BP_3 522.22 3.60 7285 478252889 ENN73274.1 3683 0.0e+00 hypothetical protein YQE_10104, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.8e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.32954 BP_3 52.75 0.44 6063 827549501 XP_012546855.1 724 4.4e-73 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.8e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.32955 BP_3 32.25 0.60 2904 91083299 XP_974608.1 2229 6.4e-248 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 7.1e-194 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2558 Negative regulator of histones Cluster-8309.32956 BP_3 93.29 2.79 1905 283046732 NP_001164313.1 1426 5.5e-155 peroxidase precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 2.0e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.32958 BP_3 72.00 1.57 2502 642923214 XP_008193658.1 1854 1.7e-204 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K04360 NTRK2, TRKB neurotrophic tyrosine kinase receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04360 Q24488 711 2.4e-73 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.32959 BP_3 48.85 1.42 1945 270007066 EFA03514.1 1118 2.9e-119 hypothetical protein TcasGA2_TC013516 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 B0BNE5 821 3.3e-86 S-formylglutathione hydrolase OS=Rattus norvegicus GN=Esd PE=2 SV=1 PF12740//PF01764//PF01694//PF07819//PF00326//PF10503//PF07578//PF07224 Chlorophyllase enzyme//Lipase (class 3)//Rhomboid family//PGAP1-like protein//Prolyl oligopeptidase family//Esterase PHB depolymerase//Lipid A Biosynthesis N-terminal domain//Chlorophyllase GO:0006508//GO:0009245//GO:0015996//GO:0006505//GO:0006886//GO:0006629//GO:0015994 proteolysis//lipid A biosynthetic process//chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport//lipid metabolic process//chlorophyll metabolic process GO:0008236//GO:0008915//GO:0004252//GO:0016788//GO:0047746 serine-type peptidase activity//lipid-A-disaccharide synthase activity//serine-type endopeptidase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3101 Esterase D Cluster-8309.3296 BP_3 3.00 0.36 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32961 BP_3 20.84 0.50 2309 91091818 XP_966528.1 932 1.3e-97 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 Q38PU3 681 6.7e-70 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007268//GO:0006810//GO:0007165//GO:0006811//GO:0044699 synaptic transmission//transport//signal transduction//ion transport//single-organism process GO:0005234//GO:0004970//GO:0004872//GO:0005230 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//receptor activity//extracellular ligand-gated ion channel activity GO:0071944//GO:0045202//GO:0016020 cell periphery//synapse//membrane -- -- Cluster-8309.32963 BP_3 13.65 1.00 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32964 BP_3 64.10 16.47 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32965 BP_3 376.88 22.04 1116 642921560 XP_008192424.1 280 2.5e-22 PREDICTED: RISC-loading complex subunit tarbp2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09239//PF04098 Topoisomerase VI B subunit, transducer//Rad52/22 family double-strand break repair protein GO:0006310//GO:0006281//GO:0006265 DNA recombination//DNA repair//DNA topological change GO:0003918//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding -- -- -- -- Cluster-8309.32966 BP_3 156.00 33.21 518 270003494 EEZ99941.1 251 2.6e-19 hypothetical protein TcasGA2_TC002737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- -- -- Cluster-8309.32967 BP_3 2773.08 33.54 4277 91077758 XP_967802.1 1416 1.8e-153 PREDICTED: fructose-1,6-bisphosphatase 1 [Tribolium castaneum]>gi|270002228|gb|EEZ98675.1| hypothetical protein TcasGA2_TC001209 [Tribolium castaneum] 229367525 BT083036.1 55 5.17859e-17 Anoplopoma fimbria clone afim-evh-526-250 Fructose-1,6-bisphosphatase 1 putative mRNA, complete cds K03841 FBP, fbp fructose-1,6-bisphosphatase I http://www.genome.jp/dbget-bin/www_bget?ko:K03841 Q3SZB7 1017 1.3e-108 Fructose-1,6-bisphosphatase 1 OS=Bos taurus GN=FBP1 PE=2 SV=3 PF13181//PF00515//PF00459//PF00316//PF13174//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Inositol monophosphatase family//Fructose-1-6-bisphosphatase//Tetratricopeptide repeat//TPR repeat GO:0006098//GO:0006096//GO:0005975//GO:0006000//GO:0046854//GO:0006013//GO:0015976//GO:0006094 pentose-phosphate shunt//glycolytic process//carbohydrate metabolic process//fructose metabolic process//phosphatidylinositol phosphorylation//mannose metabolic process//carbon utilization//gluconeogenesis GO:0042132//GO:0005515//GO:0042578 fructose 1,6-bisphosphate 1-phosphatase activity//protein binding//phosphoric ester hydrolase activity -- -- KOG1458 Fructose-1,6-bisphosphatase Cluster-8309.32968 BP_3 178.41 3.01 3151 91078902 XP_973455.1 1013 7.0e-107 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q3ZBT5 504 3.0e-49 Syntaxin-7 OS=Bos taurus GN=STX7 PE=2 SV=1 PF05739//PF00015//PF00804//PF08597//PF00957//PF05531//PF02561//PF04632 SNARE domain//Methyl-accepting chemotaxis protein (MCP) signalling domain//Syntaxin//Translation initiation factor eIF3 subunit//Synaptobrevin//Nucleopolyhedrovirus P10 protein//Flagellar protein FliS//Fusaric acid resistance protein family GO:0006446//GO:0016192//GO:0006810//GO:0007165 regulation of translational initiation//vesicle-mediated transport//transport//signal transduction GO:0004871//GO:0005515//GO:0003743 signal transducer activity//protein binding//translation initiation factor activity GO:0005852//GO:0005737//GO:0009288//GO:0005840//GO:0016020//GO:0016021//GO:0019028//GO:0005886 eukaryotic translation initiation factor 3 complex//cytoplasm//bacterial-type flagellum//ribosome//membrane//integral component of membrane//viral capsid//plasma membrane KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.32970 BP_3 81.42 0.77 5403 478258110 ENN78248.1 2446 8.2e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 209 1.61565e-102 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 3.2e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF08063//PF00400//PF01435//PF01018//PF01433//PF09127 PADR1 (NUC008) domain//WD domain, G-beta repeat//Peptidase family M48//GTP1/OBG//Peptidase family M1//Leukotriene A4 hydrolase, C-terminal GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0005515//GO:0004222//GO:0003950//GO:0008237//GO:0005525//GO:0008270 protein binding//metalloendopeptidase activity//NAD+ ADP-ribosyltransferase activity//metallopeptidase activity//GTP binding//zinc ion binding GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.32972 BP_3 232.00 3.52 3467 270014909 EFA11357.1 2170 5.3e-241 hypothetical protein TcasGA2_TC011514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4Z9 1089 4.9e-117 Protein lines OS=Drosophila melanogaster GN=lin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32973 BP_3 13.00 1.18 825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32974 BP_3 167.00 1.70 5020 332373494 AEE61888.1 1056 1.2e-111 unknown [Dendroctonus ponderosae] -- -- -- -- -- K07855 RERG Ras-related and estrogen-regulated growth inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K07855 Q8R367 325 2.8e-28 Ras-related and estrogen-regulated growth inhibitor OS=Mus musculus GN=Rerg PE=2 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG0395 Ras-related GTPase Cluster-8309.32975 BP_3 144.17 1.77 4222 642921287 XP_008192801.1 4438 0.0e+00 PREDICTED: disheveled-associated activator of morphogenesis 1 isoform X1 [Tribolium castaneum] 642921292 XM_008194582.1 488 0 PREDICTED: Tribolium castaneum disheveled-associated activator of morphogenesis 1 (LOC658864), transcript variant X4, mRNA K04512 DAAM dishevelled associated activator of morphogenesis http://www.genome.jp/dbget-bin/www_bget?ko:K04512 Q8BPM0 1369 2.0e-149 Disheveled-associated activator of morphogenesis 1 OS=Mus musculus GN=Daam1 PE=1 SV=4 PF06371//PF06367//PF01763//PF04561 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain//Herpesvirus UL6 like//RNA polymerase Rpb2, domain 2 GO:0006351//GO:0006144//GO:0016043//GO:0006206//GO:0006323//GO:0030036 transcription, DNA-templated//purine nucleobase metabolic process//cellular component organization//pyrimidine nucleobase metabolic process//DNA packaging//actin cytoskeleton organization GO:0003899//GO:0003677//GO:0003779//GO:0017048 DNA-directed RNA polymerase activity//DNA binding//actin binding//Rho GTPase binding GO:0005730 nucleolus KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.32976 BP_3 85.00 6.15 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32980 BP_3 125.20 7.76 1069 642935026 XP_008199911.1 274 1.2e-21 PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|642935028|ref|XP_008199912.1| PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|270012981|gb|EFA09429.1| hypothetical protein TcasGA2_TC010640 [Tribolium castaneum] -- -- -- -- -- K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q3T106 166 1.6e-10 Serine/arginine-rich splicing factor 7 OS=Bos taurus GN=SRSF7 PE=2 SV=1 PF00098 Zinc knuckle -- -- GO:1901363//GO:0043169//GO:0003676//GO:0097159//GO:0008270 heterocyclic compound binding//cation binding//nucleic acid binding//organic cyclic compound binding//zinc ion binding -- -- -- -- Cluster-8309.32984 BP_3 5.13 0.69 652 817088791 XP_012267229.1 139 3.2e-06 PREDICTED: cAMP-dependent protein kinase type I regulatory subunit isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- P16905 132 8.6e-07 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32985 BP_3 296.39 1.73 8544 642935636 XP_008198092.1 4543 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 6.82218e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.5e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF13180//PF00595//PF00620//PF08718 PDZ domain//PDZ domain (Also known as DHR or GLGF)//RhoGAP domain//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0051861//GO:0017089//GO:0005515 glycolipid binding//glycolipid transporter activity//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.32987 BP_3 263.60 6.55 2230 642913773 XP_008201155.1 1695 4.1e-186 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z401 330 3.2e-29 C-myc promoter-binding protein OS=Homo sapiens GN=DENND4A PE=1 SV=2 PF02055//PF01844//PF02861 O-Glycosyl hydrolase family 30//HNH endonuclease//Clp amino terminal domain, pathogenicity island component GO:0019538//GO:0006687//GO:0005975//GO:0006807//GO:0006665 protein metabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process//sphingolipid metabolic process GO:0003676//GO:0004348//GO:0004519 nucleic acid binding//glucosylceramidase activity//endonuclease activity -- -- KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.32989 BP_3 19.55 0.55 2004 642910564 XP_008200268.1 427 4.0e-39 PREDICTED: arrestin red cell isoform 2 isoform X3 [Tribolium castaneum] 642910565 XM_967463.3 117 8.23218e-52 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X4, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P51485 202 2.0e-14 Probable beta-arrestin OS=Caenorhabditis elegans GN=arr-1 PE=3 SV=2 PF05326 Seminal vesicle autoantigen (SVA) -- -- -- -- GO:0005576 extracellular region KOG3865 Arrestin Cluster-8309.32991 BP_3 41.35 0.55 3928 546678692 ERL89260.1 3267 0.0e+00 hypothetical protein D910_06633, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1260 8.2e-137 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.32992 BP_3 1286.24 21.38 3192 642910776 XP_008193405.1 2509 2.4e-280 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 2.23873e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1134 2.7e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.32993 BP_3 527.42 3.70 7164 642910776 XP_008193405.1 2410 1.6e-268 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 5.05401e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1140 1.2e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.32995 BP_3 1568.14 15.32 5226 478255927 ENN76129.1 1966 3.6e-217 hypothetical protein YQE_07349, partial [Dendroctonus ponderosae]>gi|546676523|gb|ERL87517.1| hypothetical protein D910_04909 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NRA2 315 4.2e-27 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF00379//PF07690 Insect cuticle protein//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.32997 BP_3 11.00 1.85 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32999 BP_3 756.57 7.75 4998 478260665 ENN80362.1 1376 9.0e-149 hypothetical protein YQE_03221, partial [Dendroctonus ponderosae]>gi|478269621|gb|ENN83368.1| hypothetical protein YQE_00276, partial [Dendroctonus ponderosae]>gi|546683697|gb|ERL93475.1| hypothetical protein D910_10766 [Dendroctonus ponderosae] -- -- -- -- -- K08592 SENP1 sentrin-specific protease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08592 Q9VXP4 724 1.5e-74 Platelet-activating factor acetylhydrolase IB subunit beta homolog OS=Drosophila melanogaster GN=Paf-AHalpha PE=1 SV=1 PF02902//PF00657//PF00770 Ulp1 protease family, C-terminal catalytic domain//GDSL-like Lipase/Acylhydrolase//Adenovirus endoprotease GO:0006508 proteolysis GO:0008234//GO:0016788//GO:0004197 cysteine-type peptidase activity//hydrolase activity, acting on ester bonds//cysteine-type endopeptidase activity -- -- KOG0778 Protease, Ulp1 family Cluster-8309.33001 BP_3 2682.77 65.04 2280 546674950 ERL86223.1 2254 6.4e-251 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 8.62217e-112 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1691 5.0e-187 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF03949//PF00390 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0006108//GO:0055114//GO:0015976//GO:0006099//GO:0006090 malate metabolic process//oxidation-reduction process//carbon utilization//tricarboxylic acid cycle//pyruvate metabolic process GO:0051287//GO:0004471 NAD binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.33005 BP_3 35.03 0.67 2821 91078042 XP_966587.1 612 2.0e-60 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCI3 419 2.0e-39 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33006 BP_3 1624.00 22.74 3734 642928515 XP_008193823.1 150 9.8e-07 PREDICTED: protein C-ets-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.33008 BP_3 403.65 18.20 1361 91088839 XP_970745.1 252 5.3e-19 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01788 PsbJ GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.33011 BP_3 70.12 4.74 1005 189238660 XP_972432.2 1257 1.1e-135 PREDICTED: ribosome biogenesis methyltransferase WBSCR22 [Tribolium castaneum]>gi|270008360|gb|EFA04808.1| hypothetical protein TcasGA2_TC014857 [Tribolium castaneum] -- -- -- -- -- K19306 BUD23 18S rRNA (guanine1575-N7)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K19306 Q9CY21 913 3.6e-97 Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Mus musculus GN=Wbscr22 PE=2 SV=1 PF01555//PF08241//PF07757 DNA methylase//Methyltransferase domain//Predicted AdoMet-dependent methyltransferase GO:0008152//GO:0032259//GO:0006306 metabolic process//methylation//DNA methylation GO:0008168//GO:0008170//GO:0003677 methyltransferase activity//N-methyltransferase activity//DNA binding -- -- KOG1541 Predicted protein carboxyl methylase Cluster-8309.33012 BP_3 25.69 0.34 3882 642920301 XP_008192289.1 526 2.6e-50 PREDICTED: interferon regulatory factor 2-binding protein 2 isoform X3 [Tribolium castaneum] 642920300 XM_008194067.1 94 9.81232e-39 PREDICTED: Tribolium castaneum interferon regulatory factor 2-binding protein 2 (LOC664517), transcript variant X3, mRNA -- -- -- -- Q7Z5L9 405 1.1e-37 Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens GN=IRF2BP2 PE=1 SV=2 PF00097//PF02778 Zinc finger, C3HC4 type (RING finger)//tRNA intron endonuclease, N-terminal domain GO:0051252//GO:0006388 regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0000213//GO:0046872 tRNA-intron endonuclease activity//metal ion binding GO:0000214 tRNA-intron endonuclease complex KOG3579 Predicted E3 ubiquitin ligase Cluster-8309.33013 BP_3 101.72 1.37 3866 642936487 XP_008198457.1 1993 2.0e-220 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.74337e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1098 4.9e-118 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF05699//PF10613//PF00060//PF01699 hAT family C-terminal dimerisation region//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//Sodium/calcium exchanger protein GO:0044699//GO:0006811//GO:0055085//GO:0007165//GO:0006810//GO:0007268 single-organism process//ion transport//transmembrane transport//signal transduction//transport//synaptic transmission GO:0005230//GO:0005234//GO:0004970//GO:0004872//GO:0046983 extracellular ligand-gated ion channel activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//receptor activity//protein dimerization activity GO:0016020//GO:0045202//GO:0071944//GO:0016021 membrane//synapse//cell periphery//integral component of membrane -- -- Cluster-8309.33016 BP_3 10.00 0.58 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33017 BP_3 880.44 4.70 9328 642938737 XP_008199868.1 1649 3.7e-180 PREDICTED: RNA polymerase II elongation factor ELL [Tribolium castaneum] 642938736 XM_008201646.1 257 5.8008e-129 PREDICTED: Tribolium castaneum RNA polymerase II elongation factor ELL (LOC655479), mRNA K15183 ELL RNA polymerase II elongation factor ELL http://www.genome.jp/dbget-bin/www_bget?ko:K15183 O08856 320 2.0e-27 RNA polymerase II elongation factor ELL OS=Mus musculus GN=Ell PE=2 SV=2 PF10390//PF05732 RNA polymerase II elongation factor ELL//Firmicute plasmid replication protein (RepL) GO:0006260//GO:0006276//GO:0006368 DNA replication//plasmid maintenance//transcription elongation from RNA polymerase II promoter -- -- GO:0008023 transcription elongation factor complex -- -- Cluster-8309.33022 BP_3 147.62 2.10 3685 642930462 XP_008196413.1 2488 7.6e-278 PREDICTED: phosphofurin acidic cluster sorting protein 1 [Tribolium castaneum]>gi|270009398|gb|EFA05846.1| hypothetical protein TcasGA2_TC008635 [Tribolium castaneum] 558214452 XM_006108296.1 57 3.44448e-18 PREDICTED: Myotis lucifugus phosphofurin acidic cluster sorting protein 2 (PACS2), partial mRNA -- -- -- -- Q9NP66 503 4.6e-49 High mobility group protein 20A OS=Homo sapiens GN=HMG20A PE=1 SV=1 PF07851//PF01166//PF01496 TMPIT-like protein//TSC-22/dip/bun family//V-type ATPase 116kDa subunit family GO:0015991//GO:0006355//GO:0015992 ATP hydrolysis coupled proton transport//regulation of transcription, DNA-templated//proton transport GO:0015078//GO:0003700 hydrogen ion transmembrane transporter activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667//GO:0033179 integral component of membrane//transcription factor complex//proton-transporting V-type ATPase, V0 domain KOG0381 HMG box-containing protein Cluster-8309.33025 BP_3 2886.07 75.30 2139 642910530 XP_008200251.1 1534 1.8e-167 PREDICTED: adenylyl cyclase-associated protein 1 isoform X1 [Tribolium castaneum] 332373619 BT126989.1 136 2.41142e-62 Dendroctonus ponderosae clone DPO019_B13 unknown mRNA K17261 CAP1_2, SRV2 adenylyl cyclase-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17261 P40123 1019 4.0e-109 Adenylyl cyclase-associated protein 2 OS=Homo sapiens GN=CAP2 PE=1 SV=1 PF01213//PF02205//PF08603 Adenylate cyclase associated (CAP) N terminal//WH2 motif//Adenylate cyclase associated (CAP) C terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.33026 BP_3 563.44 8.01 3681 642936428 XP_008198430.1 1447 3.9e-157 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.22011e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 535 9.0e-53 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.33028 BP_3 1318.00 25.19 2814 270007965 EFA04413.1 1862 2.2e-205 hypothetical protein TcasGA2_TC014713 [Tribolium castaneum] 642924630 XM_008196149.1 178 1.42939e-85 PREDICTED: Tribolium castaneum uncharacterized LOC663690 (LOC663690), transcript variant X3, mRNA K17494 CSRNP cysteine/serine-rich nuclear protein http://www.genome.jp/dbget-bin/www_bget?ko:K17494 Q8WYN3 588 4.9e-59 Cysteine/serine-rich nuclear protein 3 OS=Homo sapiens GN=CSRNP3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33030 BP_3 11.16 0.64 1132 642928291 XP_008195520.1 443 3.1e-41 PREDICTED: helicase SKI2W [Tribolium castaneum] -- -- -- -- -- K12599 SKI2, SKIV2L antiviral helicase SKI2 http://www.genome.jp/dbget-bin/www_bget?ko:K12599 Q15477 269 1.9e-22 Helicase SKI2W OS=Homo sapiens GN=SKIV2L PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0948 Nuclear exosomal RNA helicase MTR4, DEAD-box superfamily Cluster-8309.33032 BP_3 396.21 20.01 1246 642921313 XP_008192815.1 504 2.9e-48 PREDICTED: proteasome maturation protein [Tribolium castaneum] -- -- -- -- -- K11599 POMP, UMP1 proteasome maturation protein http://www.genome.jp/dbget-bin/www_bget?ko:K11599 Q5R9L9 288 1.3e-24 Proteasome maturation protein OS=Pongo abelii GN=POMP PE=2 SV=1 PF02230//PF00326//PF03583//PF01738 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Secretory lipase//Dienelactone hydrolase family GO:0046486//GO:0006508//GO:0016042 glycerolipid metabolic process//proteolysis//lipid catabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG2112 Lysophospholipase Cluster-8309.33033 BP_3 24.92 0.97 1527 91094775 XP_968026.1 488 2.6e-46 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9I1 145 6.3e-08 Cyclin-G1 OS=Bos taurus GN=CCNG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33037 BP_3 40.09 2.59 1038 149675209 ABR27686.1 1018 6.1e-108 cuticle proprotein proCP5.1 [Callinectes sapidus] 149675208 EF639838.1 359 0 Callinectes sapidus cuticle proprotein proCP5.1 mRNA, complete cds -- -- -- -- P81582 356 1.5e-32 Cuticle protein CP1246 OS=Cancer pagurus PE=1 SV=1 PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.33039 BP_3 38.65 0.31 6277 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 1.23032e-39 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 2.7e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF10417//PF03099//PF01496 C-terminal domain of 1-Cys peroxiredoxin//Biotin/lipoate A/B protein ligase family//V-type ATPase 116kDa subunit family GO:0015992//GO:0055114//GO:0015991//GO:0006464 proton transport//oxidation-reduction process//ATP hydrolysis coupled proton transport//cellular protein modification process GO:0051920//GO:0015078 peroxiredoxin activity//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.33040 BP_3 12.04 0.44 1607 91077822 XP_970776.1 974 1.2e-102 PREDICTED: uncharacterized protein LOC659370 [Tribolium castaneum]>gi|642914539|ref|XP_008201719.1| PREDICTED: uncharacterized protein LOC659370 [Tribolium castaneum]>gi|270001483|gb|EEZ97930.1| hypothetical protein TcasGA2_TC000317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02254//PF00056//PF00106//PF00999//PF01073//PF03435//PF01370 TrkA-N domain//lactate/malate dehydrogenase, NAD binding domain//short chain dehydrogenase//Sodium/hydrogen exchanger family//3-beta hydroxysteroid dehydrogenase/isomerase family//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family GO:0006813//GO:0008210//GO:0008152//GO:0044237//GO:0055085//GO:0055114//GO:0006694//GO:0008209//GO:0008207//GO:0006885//GO:0006812 potassium ion transport//estrogen metabolic process//metabolic process//cellular metabolic process//transmembrane transport//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process//regulation of pH//cation transport GO:0016491//GO:0015299//GO:0003824//GO:0016616//GO:0003854//GO:0050662//GO:0000166 oxidoreductase activity//solute:proton antiporter activity//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.33042 BP_3 59.37 0.60 5060 642932233 XP_008194634.1 902 8.4e-94 PREDICTED: centrosomal protein of 290 kDa-like isoform X1 [Tribolium castaneum]>gi|642932235|ref|XP_008194635.1| PREDICTED: centrosomal protein of 290 kDa-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01445//PF01166 Viral small hydrophobic protein//TSC-22/dip/bun family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0016020 transcription factor complex//membrane -- -- Cluster-8309.33043 BP_3 38.14 0.72 2840 642920970 XP_974457.2 2321 1.4e-258 PREDICTED: serine palmitoyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K00654 SPT serine palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00654 P97363 1348 3.7e-147 Serine palmitoyltransferase 2 OS=Mus musculus GN=Sptlc2 PE=2 SV=2 PF00155//PF04805//PF01212 Aminotransferase class I and II//E10-like protein conserved region//Beta-eliminating lyase GO:0055114//GO:0009058//GO:0006520 oxidation-reduction process//biosynthetic process//cellular amino acid metabolic process GO:0030170//GO:0016829//GO:0016972 pyridoxal phosphate binding//lyase activity//thiol oxidase activity -- -- KOG1357 Serine palmitoyltransferase Cluster-8309.33045 BP_3 40.45 1.18 1940 642916102 XP_971729.2 801 1.7e-82 PREDICTED: DDB1- and CUL4-associated factor 11 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q5E9I8 522 1.5e-51 DDB1- and CUL4-associated factor 11 OS=Bos taurus GN=DCAF11 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.33046 BP_3 287.00 4.41 3425 91078224 XP_969612.1 1164 2.4e-124 PREDICTED: cell division cycle protein 20 homolog [Tribolium castaneum]>gi|270002363|gb|EEZ98810.1| hypothetical protein TcasGA2_TC001383 [Tribolium castaneum] -- -- -- -- -- K03363 CDC20 cell division cycle 20, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03363 Q62623 887 1.3e-93 Cell division cycle protein 20 homolog OS=Rattus norvegicus GN=Cdc20 PE=1 SV=2 PF00498//PF00400 FHA domain//WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.33047 BP_3 7.75 1.27 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33048 BP_3 1656.38 58.56 1655 478249963 ENN70470.1 498 1.9e-47 hypothetical protein YQE_12973, partial [Dendroctonus ponderosae] -- -- -- -- -- K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q9H000 401 1.4e-37 Probable E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens GN=MKRN2 PE=1 SV=2 PF00097//PF15332//PF17123//PF12678//PF14634//PF08152//PF13639//PF00642//PF12861 Zinc finger, C3HC4 type (RING finger)//Lck-interacting transmembrane adapter 1//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//GUCT (NUC152) domain//Ring finger domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0050853//GO:0016567//GO:0050852 B cell receptor signaling pathway//protein ubiquitination//T cell receptor signaling pathway GO:0008270//GO:0046872//GO:0005524//GO:0004386//GO:0003723//GO:0005515//GO:0004842 zinc ion binding//metal ion binding//ATP binding//helicase activity//RNA binding//protein binding//ubiquitin-protein transferase activity GO:0005634//GO:0005680 nucleus//anaphase-promoting complex -- -- Cluster-8309.33049 BP_3 163.03 6.52 1497 642926721 XP_008194985.1 1279 4.8e-138 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4J913 413 5.1e-39 Facilitated trehalose transporter Tret1 OS=Drosophila grimshawi GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.3305 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.33050 BP_3 29.55 0.44 3505 478260834 ENN80486.1 1804 1.5e-198 hypothetical protein YQE_03090, partial [Dendroctonus ponderosae] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q5F364 1548 3.0e-170 Multidrug resistance-associated protein 1 OS=Gallus gallus GN=ABCC1 PE=2 SV=1 PF03193//PF00005//PF13304//PF01926//PF00664 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.33052 BP_3 471.02 5.29 4582 642910971 XP_008193488.1 686 8.5e-69 PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910973|ref|XP_008193489.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910975|ref|XP_008193490.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910977|ref|XP_008193491.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910979|ref|XP_008193492.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|270015145|gb|EFA11593.1| transforming acidic coiled-coil protein [Tribolium castaneum] -- -- -- -- -- K14281 TACC1 transforming acidic coiled-coil-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14281 O75410 289 3.8e-24 Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens GN=TACC1 PE=1 SV=2 PF10186//PF12740//PF13851//PF00038//PF08702//PF01509//PF07224 Vacuolar sorting 38 and autophagy-related subunit 14//Chlorophyllase enzyme//Growth-arrest specific micro-tubule binding//Intermediate filament protein//Fibrinogen alpha/beta chain family//TruB family pseudouridylate synthase (N terminal domain)//Chlorophyllase GO:0030168//GO:0010508//GO:0006396//GO:0007165//GO:0015996//GO:0015994//GO:0051258//GO:0048870 platelet activation//positive regulation of autophagy//RNA processing//signal transduction//chlorophyll catabolic process//chlorophyll metabolic process//protein polymerization//cell motility GO:0030674//GO:0005102//GO:0005198//GO:0047746 protein binding, bridging//receptor binding//structural molecule activity//chlorophyllase activity GO:0005577//GO:0031514//GO:0005882 fibrinogen complex//motile cilium//intermediate filament -- -- Cluster-8309.33053 BP_3 4.69 0.95 530 808127964 XP_012166893.1 156 2.8e-08 PREDICTED: longitudinals lacking protein, isoform G-like isoform X40 [Bombus terrestris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF13912//PF00412//PF01155//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//LIM domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006464 cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.33054 BP_3 63.61 0.88 3794 189241141 XP_973953.2 1608 8.6e-176 PREDICTED: probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [Tribolium castaneum]>gi|270013913|gb|EFA10361.1| hypothetical protein TcasGA2_TC012587 [Tribolium castaneum] 768410303 XM_011559102.1 284 2.29774e-144 PREDICTED: Plutella xylostella casein kinase I isoform alpha-like (LOC105388216), transcript variant X2, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67827 1103 1.3e-118 Casein kinase I isoform alpha OS=Bos taurus GN=CSNK1A1 PE=1 SV=1 PF07850//PF05445//PF00180//PF07714//PF00069 Renin receptor-like protein//Poxvirus serine/threonine protein kinase//Isocitrate/isopropylmalate dehydrogenase//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0007165//GO:0055114//GO:0006099 protein phosphorylation//signal transduction//oxidation-reduction process//tricarboxylic acid cycle GO:0016616//GO:0051287//GO:0004872//GO:0005524//GO:0000287//GO:0004449//GO:0004672 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//receptor activity//ATP binding//magnesium ion binding//isocitrate dehydrogenase (NAD+) activity//protein kinase activity GO:0016021 integral component of membrane KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.33055 BP_3 31.00 3.24 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33056 BP_3 97.00 4.59 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07716 Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.33057 BP_3 4.73 0.35 949 546677394 ERL88240.1 141 2.7e-06 hypothetical protein D910_05628, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03811//PF01007 InsA N-terminal domain//Inward rectifier potassium channel GO:0006813//GO:0006313 potassium ion transport//transposition, DNA-mediated GO:0005242 inward rectifier potassium channel activity GO:0008076//GO:0016021 voltage-gated potassium channel complex//integral component of membrane -- -- Cluster-8309.33059 BP_3 714.93 30.14 1435 546677394 ERL88240.1 324 2.5e-27 hypothetical protein D910_05628, partial [Dendroctonus ponderosae] -- -- -- -- -- K19363 LITAF lipopolysaccharide-induced tumor necrosis factor-alpha factor http://www.genome.jp/dbget-bin/www_bget?ko:K19363 Q99732 176 1.5e-11 Lipopolysaccharide-induced tumor necrosis factor-alpha factor OS=Homo sapiens GN=LITAF PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33061 BP_3 17152.29 337.68 2740 642924917 XP_008194096.1 3260 0.0e+00 PREDICTED: neprilysin-2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08635 MMEL1 membrane metallo-endopeptidase-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08635 O16796 1280 2.8e-139 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.33063 BP_3 24.27 0.44 2965 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33064 BP_3 46.57 0.64 3821 642910790 XP_008193412.1 598 1.1e-58 PREDICTED: COMM domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35779 409 3.8e-38 Venom allergen 3 OS=Solenopsis richteri PE=1 SV=2 PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33065 BP_3 278.00 16.79 1090 332376859 AEE63569.1 795 4.6e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K07555 ATPeAF1, ATPAF1, ATP11 ATP synthase mitochondrial F1 complex assembly factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07555 Q1L987 410 8.3e-39 ATP synthase mitochondrial F1 complex assembly factor 1 OS=Danio rerio GN=atpaf1 PE=2 SV=2 PF03717//PF06644 Penicillin-binding Protein dimerisation domain//ATP11 protein GO:0006461 protein complex assembly GO:0008658 penicillin binding GO:0005739 mitochondrion -- -- Cluster-8309.33066 BP_3 63.61 0.81 4070 478262631 ENN81195.1 1169 7.4e-125 hypothetical protein YQE_02385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R5M3 279 4.8e-23 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33067 BP_3 949.16 16.14 3127 642923201 XP_008193653.1 960 9.8e-101 PREDICTED: apoptotic chromatin condensation inducer in the nucleus [Tribolium castaneum]>gi|270007592|gb|EFA04040.1| hypothetical protein TcasGA2_TC014271 [Tribolium castaneum] -- -- -- -- -- K12875 ACIN1, ACINUS apoptotic chromatin condensation inducer in the nucleus http://www.genome.jp/dbget-bin/www_bget?ko:K12875 Q9JIX8 284 9.8e-24 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus GN=Acin1 PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2416 Acinus (induces apoptotic chromatin condensation) Cluster-8309.33070 BP_3 405.55 5.22 4036 642926470 XP_008191971.1 1644 6.1e-180 PREDICTED: flotillin-2 isoform X1 [Tribolium castaneum] 645037638 XM_008207769.1 344 1.0829e-177 PREDICTED: Nasonia vitripennis flotillin-2 (LOC103316081), mRNA K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61492 1513 3.9e-166 Flotillin-2 OS=Drosophila melanogaster GN=Flo-2 PE=2 SV=3 PF12052 Voltage gated calcium channel subunit beta domain 4Aa N terminal GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005245 voltage-gated calcium channel activity GO:0005891 voltage-gated calcium channel complex -- -- Cluster-8309.33074 BP_3 16147.99 691.68 1417 823432435 XP_012422688.1 237 3.0e-17 PREDICTED: LOW QUALITY PROTEIN: NAC-alpha domain-containing protein 1 [Odobenus rosmarus divergens] -- -- -- -- -- -- -- -- -- O77788 184 1.7e-12 Neurofilament medium polypeptide OS=Bos taurus GN=NEFM PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33075 BP_3 388.00 8.57 2474 642924825 XP_967668.2 889 1.3e-92 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I922 428 1.6e-40 Regucalcin OS=Xenopus laevis GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33076 BP_3 4.00 0.72 558 780637233 XP_011687047.1 166 2.0e-09 PREDICTED: zinc finger protein 90-like [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04988//PF13465//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.33077 BP_3 333.68 3.78 4544 332374512 AEE62397.1 1661 7.4e-182 unknown [Dendroctonus ponderosae]>gi|478256842|gb|ENN77017.1| hypothetical protein YQE_06511, partial [Dendroctonus ponderosae]>gi|546673798|gb|ERL85342.1| hypothetical protein D910_02762 [Dendroctonus ponderosae] 557020770 XM_006010638.1 35 7.22214e-06 PREDICTED: Latimeria chalumnae alcohol dehydrogenase class-3-like (LOC102353852), mRNA K00121 frmA, ADH5, adhC S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00121 P79896 1475 1.1e-161 Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1 PF02826//PF09174//PF03721//PF00107//PF00637//PF08240//PF08097 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Maf1 regulator//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Zinc-binding dehydrogenase//Region in Clathrin and VPS//Alcohol dehydrogenase GroES-like domain//Conotoxin T-superfamily GO:0006886//GO:0016480//GO:0016192//GO:0055114 intracellular protein transport//negative regulation of transcription from RNA polymerase III promoter//vesicle-mediated transport//oxidation-reduction process GO:0051287//GO:0016616 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005576 extracellular region KOG0022 Alcohol dehydrogenase, class III Cluster-8309.33078 BP_3 548.00 16.89 1856 91082011 XP_969843.1 1533 2.1e-167 PREDICTED: aladin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NRG9 609 1.2e-61 Aladin OS=Homo sapiens GN=AAAS PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33079 BP_3 98.72 1.70 3095 478253436 ENN73776.1 1496 6.8e-163 hypothetical protein YQE_09622, partial [Dendroctonus ponderosae] 676485074 XM_009065298.1 66 2.86719e-23 Lottia gigantea hypothetical protein partial mRNA K11141 ENPEP glutamyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11141 Q32LQ0 1079 6.3e-116 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433//PF08040 Peptidase family M1//MNLL subunit GO:0006118 obsolete electron transport GO:0003954//GO:0008237//GO:0008270 NADH dehydrogenase activity//metallopeptidase activity//zinc ion binding GO:0005739 mitochondrion -- -- Cluster-8309.33080 BP_3 212.00 39.55 550 478263054 ENN81454.1 250 3.7e-19 hypothetical protein YQE_02147, partial [Dendroctonus ponderosae]>gi|546686038|gb|ERL95438.1| hypothetical protein D910_12701 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09074//PF01255 Mer2//Putative undecaprenyl diphosphate synthase GO:0007131 reciprocal meiotic recombination GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0000794 condensed nuclear chromosome -- -- Cluster-8309.33081 BP_3 41.00 15.66 417 557771946 XP_005185631.1 158 1.3e-08 PREDICTED: uncharacterized protein LOC101888893 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33085 BP_3 1423.00 54.51 1550 91078136 XP_973521.1 1959 7.0e-217 PREDICTED: heat shock 70 kDa protein cognate 2 [Tribolium castaneum]>gi|270001374|gb|EEZ97821.1| hypothetical protein TcasGA2_TC000188 [Tribolium castaneum] 254578007 XM_002494945.1 143 2.23029e-66 Zygosaccharomyces rouxii hypothetical protein (ZYRO0B00836g) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11146 1746 1.4e-193 Heat shock 70 kDa protein cognate 2 OS=Drosophila melanogaster GN=Hsc70-2 PE=1 SV=2 PF06723//PF02782//PF01968 MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//Hydantoinase/oxoprolinase GO:0005975//GO:0000902 carbohydrate metabolic process//cell morphogenesis GO:0005524//GO:0016773//GO:0016787 ATP binding//phosphotransferase activity, alcohol group as acceptor//hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.33088 BP_3 784.89 12.28 3373 91078144 XP_973718.1 3646 0.0e+00 PREDICTED: uncharacterized protein LOC662535 [Tribolium castaneum]>gi|270002344|gb|EEZ98791.1| hypothetical protein TcasGA2_TC001355 [Tribolium castaneum] 195498296 XM_002096426.1 190 3.66448e-92 Drosophila yakuba GE25042 (Dyak\GE25042), partial mRNA -- -- -- -- Q8C419 198 9.9e-14 Probable G-protein coupled receptor 158 OS=Mus musculus GN=Gpr158 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.33089 BP_3 1084.55 23.45 2521 478251931 ENN72369.1 1766 2.7e-194 hypothetical protein YQE_11004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C419 198 7.4e-14 Probable G-protein coupled receptor 158 OS=Mus musculus GN=Gpr158 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.33090 BP_3 213.99 4.06 2835 478258160 ENN78298.1 1141 9.1e-122 hypothetical protein YQE_05448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZV5 894 1.6e-94 Cysteine and histidine-rich protein 1 homolog OS=Drosophila melanogaster GN=CG32486 PE=2 SV=2 PF02176//PF14634//PF03145 TRAF-type zinc finger//zinc-RING finger domain//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.33091 BP_3 1139.70 14.29 4137 270007410 EFA03858.1 1820 2.4e-200 hypothetical protein TcasGA2_TC013974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33092 BP_3 265.31 4.53 3113 134131322 BAF49604.1 893 5.7e-93 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 490 1.3e-47 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00089//PF00704 Trypsin//Glycosyl hydrolases family 18 GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004252 hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type endopeptidase activity -- -- KOG2806 Chitinase Cluster-8309.33094 BP_3 578.50 8.17 3704 91084469 XP_970666.1 1691 2.0e-185 PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925528|ref|XP_008194588.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925531|ref|XP_008194589.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum] 817200928 XM_012420774.1 171 1.46936e-81 PREDICTED: Orussus abietinus transcription factor Sp1-like (LOC105697447), transcript variant X5, mRNA -- -- -- -- P18722 282 2.0e-23 Gastrula zinc finger protein XlCGF46.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF05191//PF13465//PF00096 Adenylate kinase, active site lid//Zinc-finger double domain//Zinc finger, C2H2 type GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.33095 BP_3 381.84 3.52 5519 664763595 XP_008539455.1 327 4.3e-27 PREDICTED: macrophage mannose receptor 1 [Equus przewalskii] -- -- -- -- -- -- -- -- -- P22897 311 1.3e-26 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03161//PF03791 LAGLIDADG DNA endonuclease family//KNOX2 domain -- -- GO:0004519//GO:0003677 endonuclease activity//DNA binding GO:0005634 nucleus -- -- Cluster-8309.33096 BP_3 933.00 85.61 817 674304034 AIL23548.1 633 2.1e-63 glutathione S-transferase sigma [Tenebrio molitor] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 568 3.0e-57 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13409//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.33097 BP_3 33.29 1.59 1299 189235746 XP_967247.2 500 8.9e-48 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 297 1.3e-25 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137//PF08117 Adenosine-deaminase (editase) domain//Ptu family GO:0006396//GO:0006807//GO:0009405//GO:0006810//GO:0006144 RNA processing//nitrogen compound metabolic process//pathogenesis//transport//purine nucleobase metabolic process GO:0019855//GO:0003723//GO:0004000 calcium channel inhibitor activity//RNA binding//adenosine deaminase activity GO:0005576 extracellular region KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.33099 BP_3 2504.00 239.81 795 546684965 ERL94539.1 362 5.4e-32 hypothetical protein D910_11816 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q17015 270 1.0e-22 Cuticle protein OS=Anopheles gambiae GN=Ccp84Ab PE=2 SV=3 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.3310 BP_3 270.77 10.80 1500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33100 BP_3 10.26 0.50 1273 478256929 ENN77098.1 214 1.3e-14 hypothetical protein YQE_06433, partial [Dendroctonus ponderosae]>gi|546683037|gb|ERL92903.1| hypothetical protein D910_10208 [Dendroctonus ponderosae] -- -- -- -- -- K11587 CBX5, HP1A chromobox protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11587 P45973 155 3.6e-09 Chromobox protein homolog 5 OS=Homo sapiens GN=CBX5 PE=1 SV=1 PF05432 Bone sialoprotein II (BSP-II) GO:0007155//GO:0001503 cell adhesion//ossification -- -- GO:0005576 extracellular region KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.33102 BP_3 18119.76 1236.59 998 332374430 AEE62356.1 617 1.8e-61 unknown [Dendroctonus ponderosae] 347967155 XM_003435977.1 105 1.88906e-45 Anopheles gambiae str. PEST AGAP002085-PC (AgaP_AGAP002085) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33104 BP_3 920.19 39.35 1419 332375458 AEE62870.1 1441 7.4e-157 unknown [Dendroctonus ponderosae]>gi|478250250|gb|ENN70750.1| hypothetical protein YQE_12539, partial [Dendroctonus ponderosae]>gi|546685945|gb|ERL95359.1| hypothetical protein D910_12624 [Dendroctonus ponderosae] -- -- -- -- -- K10424 DCTN2 dynactin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10424 Q1HQF2 837 3.3e-88 Probable dynactin subunit 2 OS=Aedes aegypti GN=Dmn PE=2 SV=2 PF07536//PF01544//PF04513//PF15724//PF08702 HWE histidine kinase//CorA-like Mg2+ transporter protein//Baculovirus polyhedron envelope protein, PEP, C terminus//TMEM119 family//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0001503//GO:0055085//GO:0030168//GO:0016310//GO:0030001 protein polymerization//signal transduction//ossification//transmembrane transport//platelet activation//phosphorylation//metal ion transport GO:0004673//GO:0005102//GO:0005198//GO:0030674//GO:0046873 protein histidine kinase activity//receptor binding//structural molecule activity//protein binding, bridging//metal ion transmembrane transporter activity GO:0005577//GO:0019028//GO:0016020//GO:0019031//GO:0009365 fibrinogen complex//viral capsid//membrane//viral envelope//protein histidine kinase complex KOG3958 Putative dynamitin Cluster-8309.33105 BP_3 549.15 4.68 5953 91088115 XP_969791.1 1930 6.2e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.9e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF04851//PF01105//PF00270 Type III restriction enzyme, res subunit//emp24/gp25L/p24 family/GOLD//DEAD/DEAH box helicase GO:0006810 transport GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0008026 ATP binding//nucleic acid binding//DNA binding//hydrolase activity//ATP-dependent helicase activity GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.33106 BP_3 995.73 13.36 3885 646705667 KDR13254.1 541 4.7e-52 hypothetical protein L798_12642, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- B4DXR9 470 3.3e-45 Zinc finger protein 732 OS=Homo sapiens GN=ZNF732 PE=2 SV=1 PF13465//PF16622//PF00122//PF13912//PF07664//PF00096//PF01077//PF07776 Zinc-finger double domain//zinc-finger C2H2-type//E1-E2 ATPase//C2H2-type zinc finger//Ferrous iron transport protein B C terminus//Zinc finger, C2H2 type//Nitrite and sulphite reductase 4Fe-4S domain//Zinc-finger associated domain (zf-AD) GO:0055114//GO:0015684 oxidation-reduction process//ferrous iron transport GO:0015093//GO:0016491//GO:0051536//GO:0000166//GO:0008270//GO:0020037//GO:0046872 ferrous iron transmembrane transporter activity//oxidoreductase activity//iron-sulfur cluster binding//nucleotide binding//zinc ion binding//heme binding//metal ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.33108 BP_3 1263.66 43.84 1681 91085165 XP_970735.1 1565 3.7e-171 PREDICTED: septin-1 [Tribolium castaneum]>gi|270008471|gb|EFA04919.1| hypothetical protein TcasGA2_TC014984 [Tribolium castaneum] 213514885 NM_001140440.1 121 4.11255e-54 Salmo salar septin 2 (sept2), mRNA >gnl|BL_ORD_ID|5992956 Salmo salar clone ssal-rgf-535-071 Septin-2 putative mRNA, complete cds K16942 SEPT2 septin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16942 P42207 1406 4.1e-154 Septin-1 OS=Drosophila melanogaster GN=Sep1 PE=1 SV=1 PF03193//PF00005//PF04548//PF00071//PF04670//PF00735//PF08477//PF01926//PF05049 Protein of unknown function, DUF258//ABC transporter//AIG1 family//Ras family//Gtr1/RagA G protein conserved region//Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Interferon-inducible GTPase (IIGP) GO:0007049//GO:0007264 cell cycle//small GTPase mediated signal transduction GO:0005524//GO:0003924//GO:0005525//GO:0016887 ATP binding//GTPase activity//GTP binding//ATPase activity GO:0031105//GO:0016020 septin complex//membrane -- -- Cluster-8309.3311 BP_3 2.00 0.87 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33110 BP_3 803.96 32.15 1497 189238926 XP_001811313.1 931 1.1e-97 PREDICTED: acyl-CoA-binding domain-containing protein 5A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641E3 357 1.6e-32 Acyl-CoA-binding domain-containing protein 5 OS=Xenopus laevis GN=acbd5 PE=2 SV=1 PF00887//PF09177//PF04728 Acyl CoA binding protein//Syntaxin 6, N-terminal//Lipoprotein leucine-zipper GO:0048193 Golgi vesicle transport GO:0000062 fatty-acyl-CoA binding GO:0019867//GO:0016020 outer membrane//membrane KOG0817 Acyl-CoA-binding protein Cluster-8309.33111 BP_3 621.38 11.41 2917 91086235 XP_966692.1 3186 0.0e+00 PREDICTED: transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum]>gi|270011017|gb|EFA07465.1| transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum] 817081112 XM_012407627.1 596 0 PREDICTED: Athalia rosae transitional endoplasmic reticulum ATPase TER94 (LOC105690094), transcript variant X2, mRNA K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q7KN62 2968 0.0e+00 Transitional endoplasmic reticulum ATPase TER94 OS=Drosophila melanogaster GN=TER94 PE=1 SV=1 PF07728//PF01695//PF00158//PF01057//PF00004//PF02367//PF06414//PF02562//PF00931//PF14532//PF06068//PF01443//PF05496//PF00437//PF07724//PF07726//PF03266//PF00005//PF04851//PF01637//PF02456//PF00910 AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein//NB-ARC domain//Sigma-54 interaction domain//TIP49 C-terminus//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//NTPase//ABC transporter//Type III restriction enzyme, res subunit//Archaeal ATPase//Adenovirus IVa2 protein//RNA helicase GO:0006310//GO:0002949//GO:0006355//GO:0006281//GO:0006810//GO:0019079//GO:0019083 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair//transport//viral genome replication//viral transcription GO:0003724//GO:0017111//GO:0009378//GO:0043531//GO:0003723//GO:0003678//GO:0003677//GO:0016887//GO:0016301//GO:0008134//GO:0005524//GO:0016787//GO:0098519 RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//ADP binding//RNA binding//DNA helicase activity//DNA binding//ATPase activity//kinase activity//transcription factor binding//ATP binding//hydrolase activity//nucleotide phosphatase activity, acting on free nucleotides GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0730 AAA+-type ATPase Cluster-8309.33112 BP_3 390.80 2.98 6604 189237519 XP_973030.2 3420 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.7e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF05485//PF03470//PF01667//PF13465//PF09367 THAP domain//XS zinc finger domain//Ribosomal protein S27//Zinc-finger double domain//CpeS-like protein GO:0017009//GO:0042254//GO:0031047//GO:0006412 protein-phycocyanobilin linkage//ribosome biogenesis//gene silencing by RNA//translation GO:0046872//GO:0003735//GO:0003676 metal ion binding//structural constituent of ribosome//nucleic acid binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.33116 BP_3 13.19 0.68 1228 642937482 XP_008198857.1 257 1.3e-19 PREDICTED: protein tramtrack, beta isoform-like isoform X18 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33117 BP_3 264.00 4.13 3374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33118 BP_3 146.33 2.79 2819 189238157 XP_976123.2 1599 7.0e-175 PREDICTED: adiponectin receptor protein isoform X2 [Tribolium castaneum] 332372817 BT126587.1 395 0 Dendroctonus ponderosae clone DPO1421_D03 unknown mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 1306 2.7e-142 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF03006//PF00060 Haemolysin-III related//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.33120 BP_3 2760.96 47.12 3116 270000732 EEZ97179.1 2876 0.0e+00 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] 642937909 XM_008202132.1 344 8.33833e-178 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 1179 1.6e-127 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 PF06220//PF00096 U1 zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.33126 BP_3 13.00 0.33 2189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03094 Mlo family GO:0006952 defense response -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33128 BP_3 1648.34 47.26 1973 642934812 XP_008197820.1 552 1.3e-53 PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934814|ref|XP_008197821.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934816|ref|XP_008197822.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934818|ref|XP_008197823.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum] -- -- -- -- -- K17555 PPP1R14B protein phosphatase 1 regulatory subunit 14B http://www.genome.jp/dbget-bin/www_bget?ko:K17555 -- -- -- -- PF05361 PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation -- -- GO:0005737 cytoplasm -- -- Cluster-8309.33131 BP_3 28.37 0.77 2075 91076690 XP_971724.1 912 2.4e-95 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 110 6.64015e-48 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 B2GV71 595 5.6e-60 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Rattus norvegicus GN=Ndufaf5 PE=2 SV=1 PF05175 Methyltransferase small domain -- -- GO:0008168 methyltransferase activity -- -- KOG2940 Predicted methyltransferase Cluster-8309.33132 BP_3 38.95 0.36 5463 642927835 XP_972081.2 781 9.7e-80 PREDICTED: LOW QUALITY PROTEIN: probable glucosamine 6-phosphate N-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00621 GNPNAT1, GNA1 glucosamine-phosphate N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00621 Q9VAI0 611 2.1e-61 Probable glucosamine 6-phosphate N-acetyltransferase OS=Drosophila melanogaster GN=CG1969 PE=2 SV=1 PF00583//PF13508//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3396 Glucosamine-phosphate N-acetyltransferase Cluster-8309.33133 BP_3 29.16 0.48 3216 662212467 XP_008479970.1 231 3.4e-16 PREDICTED: zinc finger protein 425-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF08063//PF13465//PF00096 BED zinc finger//PADR1 (NUC008) domain//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003950//GO:0046872//GO:0003677 NAD+ ADP-ribosyltransferase activity//metal ion binding//DNA binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.33134 BP_3 859.00 22.46 2135 91087123 XP_975206.1 1775 2.1e-195 PREDICTED: mRNA export factor [Tribolium castaneum]>gi|270011088|gb|EFA07536.1| RAE1 RNA export 1 homolog [Tribolium castaneum] 807019675 XM_004520208.2 175 5.02882e-84 PREDICTED: Ceratitis capitata mRNA export factor (LOC101455898), mRNA K14298 RAE1, GLE2 mRNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14298 Q7ZWF0 1424 4.3e-156 mRNA export factor OS=Danio rerio GN=rae1 PE=2 SV=2 PF08122//PF00400 NADH-ubiquinone oxidoreductase B12 subunit family//WD domain, G-beta repeat GO:0022900 electron transport chain GO:0005515 protein binding GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG0647 mRNA export protein (contains WD40 repeats) Cluster-8309.33135 BP_3 65.63 0.89 3834 402535161 AFQ62107.1 809 3.9e-83 female-specific doublesex isoform f2 [Tribolium castaneum] 642928399 XR_511419.1 167 2.5459e-79 PREDICTED: Tribolium castaneum male-specific doublesex isoform m (LOC660453), transcript variant X2, misc_RNA K19488 DMRT1 doublesex- and mab-3-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19488 P23023 260 7.3e-21 Protein doublesex OS=Drosophila melanogaster GN=dsx PE=1 SV=1 PF00751//PF01104 DM DNA binding domain//Bunyavirus non-structural protein NS-s GO:0006355//GO:0016032 regulation of transcription, DNA-templated//viral process GO:0043565 sequence-specific DNA binding -- -- KOG3815 Transcription factor Doublesex Cluster-8309.33136 BP_3 5775.78 48.51 6030 642929745 XP_008195958.1 2579 3.5e-288 PREDICTED: uncharacterized protein LOC664426 isoform X1 [Tribolium castaneum]>gi|270010581|gb|EFA07029.1| hypothetical protein TcasGA2_TC010001 [Tribolium castaneum] 242020070 XM_002430435.1 44 9.53512e-11 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF00008//PF06112//PF03067//PF09172//PF05887//PF05433 EGF-like domain//Gammaherpesvirus capsid protein//Chitin binding domain//Domain of unknown function (DUF1943)//Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain GO:0006869 lipid transport GO:0005515//GO:0005319 protein binding//lipid transporter activity GO:0019867//GO:0016020//GO:0019028 outer membrane//membrane//viral capsid -- -- Cluster-8309.33137 BP_3 40.11 0.32 6351 642935437 XP_971822.3 1690 4.5e-185 PREDICTED: pancreatic triacylglycerol lipase [Tribolium castaneum] -- -- -- -- -- K11092 SNRPA1 U2 small nuclear ribonucleoprotein A' http://www.genome.jp/dbget-bin/www_bget?ko:K11092 Q4R8Y8 702 6.7e-72 U2 small nuclear ribonucleoprotein A' OS=Macaca fascicularis GN=SNRPA1 PE=2 SV=1 PF02230//PF13855//PF07714//PF00975//PF00069 Phospholipase/Carboxylesterase//Leucine rich repeat//Protein tyrosine kinase//Thioesterase domain//Protein kinase domain GO:0006468//GO:0009058 protein phosphorylation//biosynthetic process GO:0004672//GO:0005515//GO:0016788//GO:0005524//GO:0016787 protein kinase activity//protein binding//hydrolase activity, acting on ester bonds//ATP binding//hydrolase activity -- -- KOG1644 U2-associated snRNP A' protein Cluster-8309.33141 BP_3 99.00 6.29 1050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33142 BP_3 408.87 9.06 2468 91085407 XP_967344.1 1098 7.7e-117 PREDICTED: peroxisome assembly protein 12 [Tribolium castaneum] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 1.8e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF07685//PF13639//PF12678//PF00097 CobB/CobQ-like glutamine amidotransferase domain//Ring finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0046872//GO:0003824//GO:0008270 protein binding//metal ion binding//catalytic activity//zinc ion binding -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.33144 BP_3 503.27 7.33 3599 642933582 XP_008197481.1 1654 3.8e-181 PREDICTED: protein 5NUC-like [Tribolium castaneum]>gi|270011322|gb|EFA07770.1| hypothetical protein TcasGA2_TC005324 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q9XZ43 1159 3.9e-125 Protein 5NUC OS=Lutzomyia longipalpis GN=5NUC PE=1 SV=1 PF03615//PF00149//PF02872 GCM motif protein//Calcineurin-like phosphoesterase//5'-nucleotidase, C-terminal domain GO:0006355//GO:0009166 regulation of transcription, DNA-templated//nucleotide catabolic process GO:0005488//GO:0003677//GO:0016787 binding//DNA binding//hydrolase activity -- -- -- -- Cluster-8309.33146 BP_3 11.00 5.79 381 546677957 ERL88690.1 200 1.6e-13 hypothetical protein D910_06073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33147 BP_3 64.00 4.30 1009 170321839 BAG14264.1 383 2.5e-34 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P16295 155 2.9e-09 Coagulation factor IX (Fragment) OS=Cavia porcellus GN=F9 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33149 BP_3 13.50 0.34 2181 642912278 XP_967486.2 462 3.8e-43 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BJR6 139 4.4e-07 Serine protease 27 OS=Mus musculus GN=Prss27 PE=2 SV=1 PF00757//PF00089//PF00296 Furin-like cysteine rich region//Trypsin//Luciferase-like monooxygenase GO:0006468//GO:0007169//GO:0055114//GO:0006508 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway//oxidation-reduction process//proteolysis GO:0016705//GO:0005524//GO:0004714//GO:0004252 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ATP binding//transmembrane receptor protein tyrosine kinase activity//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.3315 BP_3 2.00 0.45 507 874446720 XP_012955380.1 646 4.1e-65 PREDICTED: LOW QUALITY PROTEIN: 60S ribosomal protein L23a [Anas platyrhynchos] 694967839 XM_511361.4 507 0 PREDICTED: Pan troglodytes ribosomal protein L23a (RPL23A), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62750 646 1.7e-66 60S ribosomal protein L23a OS=Homo sapiens GN=RPL23A PE=1 SV=1 PF00276//PF00347 Ribosomal protein L23//Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.33150 BP_3 355.52 7.81 2485 642919219 XP_969254.2 711 5.8e-72 PREDICTED: peroxiredoxin-5, mitochondrial [Tribolium castaneum] -- -- -- -- -- K11187 PRDX5 peroxiredoxin 5, atypical 2-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11187 Q9GLW9 460 3.0e-44 Peroxiredoxin-5, mitochondrial OS=Papio hamadryas GN=PRDX5 PE=2 SV=1 PF00578//PF16367//PF08534//PF01848//PF00076 AhpC/TSA family//RNA recognition motif//Redoxin//Hok/gef family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0055114 oxidation-reduction process GO:0016209//GO:0003676//GO:0016491 antioxidant activity//nucleic acid binding//oxidoreductase activity GO:0016020 membrane KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin Cluster-8309.33154 BP_3 581.15 15.11 2145 642939420 XP_008200384.1 2172 1.9e-241 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha isoform X1 [Tribolium castaneum]>gi|270016503|gb|EFA12949.1| hypothetical protein TcasGA2_TC005069 [Tribolium castaneum] 801401384 XM_012205696.1 102 1.92312e-43 PREDICTED: Atta cephalotes phosphatidylinositol 4-kinase type 2-alpha (LOC105624338), mRNA K13711 PI4K2 phosphatidylinositol 4-kinase type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13711 Q6DCQ8 1416 3.7e-155 Phosphatidylinositol 4-kinase type 2-beta OS=Xenopus laevis GN=pi4k2b PE=2 SV=1 PF07945//PF14987//PF00454//PF17050 Janus-atracotoxin//NADH dehydrogenase 1 alpha subcomplex subunit 3//Phosphatidylinositol 3- and 4-kinase//Altered inheritance of mitochondria 5 GO:0042407//GO:0009405 cristae formation//pathogenesis GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0005576//GO:0005747//GO:0061617//GO:0005743//GO:0044284 extracellular region//mitochondrial respiratory chain complex I//MICOS complex//mitochondrial inner membrane//mitochondrial crista junction KOG2381 Phosphatidylinositol 4-kinase Cluster-8309.33155 BP_3 718.49 15.09 2587 283046740 NP_001164317.1 1036 1.2e-109 TAK1-associated binding protein 2 isoform B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K90 180 9.3e-12 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Mus musculus GN=Tab2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.33156 BP_3 251.19 1.92 6600 642931369 XP_008196550.1 7220 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931368 XM_008198328.1 1020 0 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X6, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5900 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF00225//PF00498//PF00959//PF07353//PF10390//PF05171//PF05014 Kinesin motor domain//FHA domain//Phage lysozyme//Uroplakin II//RNA polymerase II elongation factor ELL//Haemin-degrading HemS.ChuX domain//Nucleoside 2-deoxyribosyltransferase GO:0006206//GO:0016998//GO:0006368//GO:0005975//GO:0006826//GO:0061024//GO:0007017//GO:0009253//GO:0009159//GO:0007018 pyrimidine nucleobase metabolic process//cell wall macromolecule catabolic process//transcription elongation from RNA polymerase II promoter//carbohydrate metabolic process//iron ion transport//membrane organization//microtubule-based process//peptidoglycan catabolic process//deoxyribonucleoside monophosphate catabolic process//microtubule-based movement GO:0008017//GO:0003796//GO:0070694//GO:0003777//GO:0005515//GO:0050144//GO:0005524 microtubule binding//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//microtubule motor activity//protein binding//nucleoside deoxyribosyltransferase activity//ATP binding GO:0005874//GO:0008023//GO:0030176//GO:0045298 microtubule//transcription elongation factor complex//integral component of endoplasmic reticulum membrane//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.33157 BP_3 654.00 11.57 3017 270014262 EFA10710.1 289 6.0e-23 domino [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33158 BP_3 532.00 51.57 789 546674022 ERL85515.1 346 3.9e-30 hypothetical protein D910_02934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15330 126 5.2e-06 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF02909 Tetracyclin repressor, C-terminal all-alpha domain GO:0045892 negative regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.33159 BP_3 314.00 105.92 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33162 BP_3 1899.98 21.41 4570 91088509 XP_971592.1 4199 0.0e+00 PREDICTED: pre-mRNA-processing factor 6 [Tribolium castaneum]>gi|270011722|gb|EFA08170.1| hypothetical protein TcasGA2_TC005794 [Tribolium castaneum] 542217355 XM_003439025.2 118 5.26887e-52 PREDICTED: Oreochromis niloticus pre-mRNA-processing factor 6-like (LOC100696507), mRNA K12855 PRPF6, PRP6 pre-mRNA-processing factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12855 O94906 3341 0.0e+00 Pre-mRNA-processing factor 6 OS=Homo sapiens GN=PRPF6 PE=1 SV=1 PF13414//PF01267//PF01115//PF13371//PF00515//PF02259//PF05843//PF02099//PF13181//PF06424 TPR repeat//F-actin capping protein alpha subunit//F-actin capping protein, beta subunit//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Suppressor of forked protein (Suf)//Josephin//Tetratricopeptide repeat//PRP1 splicing factor, N-terminal GO:0000398//GO:0051016//GO:0006397 mRNA splicing, via spliceosome//barbed-end actin filament capping//mRNA processing GO:0005515//GO:0008242 protein binding//omega peptidase activity GO:0008290//GO:0005634 F-actin capping protein complex//nucleus KOG0495 HAT repeat protein Cluster-8309.33163 BP_3 13.79 0.57 1451 642919440 XP_008191870.1 1118 2.2e-119 PREDICTED: striatin-3 [Tribolium castaneum] 241676655 XM_002412520.1 89 2.17494e-36 Ixodes scapularis striatin, putative, mRNA K17608 STRN1_3_4 striatin 1/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17608 Q13033 782 8.1e-82 Striatin-3 OS=Homo sapiens GN=STRN3 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats Cluster-8309.33164 BP_3 849.21 20.87 2253 642919440 XP_008191870.1 2286 1.2e-254 PREDICTED: striatin-3 [Tribolium castaneum] 768432640 XM_011559352.1 116 3.33525e-51 PREDICTED: Plutella xylostella striatin-3 (LOC105388449), mRNA K17608 STRN1_3_4 striatin 1/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17608 Q13033 782 1.3e-81 Striatin-3 OS=Homo sapiens GN=STRN3 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats Cluster-8309.33165 BP_3 112.52 2.98 2113 546678779 ERL89331.1 640 8.4e-64 hypothetical protein D910_06703 [Dendroctonus ponderosae] 291201233 FP340408.1 101 6.81186e-43 33G08_SfBAC_fin, Spodoptera frugiperda BAC, egg DNA K17608 STRN1_3_4 striatin 1/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17608 Q9ERG2 549 1.2e-54 Striatin-3 OS=Mus musculus GN=Strn3 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0295 WD40 repeat-containing protein Cluster-8309.33166 BP_3 288.48 7.70 2098 546678779 ERL89331.1 640 8.4e-64 hypothetical protein D910_06703 [Dendroctonus ponderosae] 291201233 FP340408.1 101 6.76269e-43 33G08_SfBAC_fin, Spodoptera frugiperda BAC, egg DNA K17608 STRN1_3_4 striatin 1/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17608 Q9ERG2 549 1.2e-54 Striatin-3 OS=Mus musculus GN=Strn3 PE=1 SV=1 PF00400//PF14304 WD domain, G-beta repeat//Transcription termination and cleavage factor C-terminal GO:0031124 mRNA 3'-end processing GO:0005515 protein binding -- -- KOG0295 WD40 repeat-containing protein Cluster-8309.33167 BP_3 70.11 0.63 5680 270003643 EFA00091.1 2511 2.5e-280 hypothetical protein TcasGA2_TC002906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54K36 150 6.1e-08 Uncharacterized protein DDB_G0287625 OS=Dictyostelium discoideum GN=DDB_G0287625 PE=4 SV=1 PF08397//PF14604//PF00018 IRSp53/MIM homology domain//Variant SH3 domain//SH3 domain GO:0007009 plasma membrane organization GO:0005515 protein binding -- -- -- -- Cluster-8309.33169 BP_3 1020.48 25.73 2203 478251878 ENN72317.1 1686 4.5e-185 hypothetical protein YQE_11060, partial [Dendroctonus ponderosae] -- -- -- -- -- K02216 CHK1 serine/threonine-protein kinase Chk1 http://www.genome.jp/dbget-bin/www_bget?ko:K02216 O61661 1014 1.5e-108 Serine/threonine-protein kinase grp OS=Drosophila melanogaster GN=grp PE=1 SV=2 PF00069//PF07714//PF00924 Protein kinase domain//Protein tyrosine kinase//Mechanosensitive ion channel GO:0055085//GO:0006468 transmembrane transport//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016020 membrane KOG0590 Checkpoint kinase and related serine/threonine protein kinases Cluster-8309.33171 BP_3 104.31 5.43 1217 91083379 XP_967173.1 375 2.6e-33 PREDICTED: heat shock factor-binding protein 1 [Tribolium castaneum]>gi|270007782|gb|EFA04230.1| hypothetical protein TcasGA2_TC014481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDI2 225 2.6e-17 Heat shock factor-binding protein 1 OS=Pongo abelii GN=HSBP1 PE=3 SV=1 PF02865//PF04513//PF00103//PF06152//PF05478//PF06008 STAT protein, protein interaction domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Somatotropin hormone family//Phage minor capsid protein 2//Prominin//Laminin Domain I GO:0007165//GO:0030334//GO:0045995//GO:0006355//GO:0030155 signal transduction//regulation of cell migration//regulation of embryonic development//regulation of transcription, DNA-templated//regulation of cell adhesion GO:0005179//GO:0005198//GO:0003700//GO:0004871//GO:0005102 hormone activity//structural molecule activity//transcription factor activity, sequence-specific DNA binding//signal transducer activity//receptor binding GO:0005667//GO:0019031//GO:0019028//GO:0016021//GO:0005576 transcription factor complex//viral envelope//viral capsid//integral component of membrane//extracellular region KOG4117 Heat shock factor binding protein Cluster-8309.33172 BP_3 50.00 1.08 2528 91087217 XP_975478.1 949 1.5e-99 PREDICTED: paired box pox-meso protein [Tribolium castaneum] 9967368 AB039660.1 138 2.2088e-63 Lethenteron camtschaticum Pax-9 mRNA for paired box protein, complete cds K09382 PAX1_9 paired box protein 1/9 http://www.genome.jp/dbget-bin/www_bget?ko:K09382 P23757 650 2.9e-66 Paired box pox-meso protein OS=Drosophila melanogaster GN=Poxm PE=2 SV=3 PF02751//PF00292 Transcription initiation factor IIA, gamma subunit//'Paired box' domain GO:0006355//GO:0006367 regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005672 transcription factor TFIIA complex KOG3517 Transcription factor PAX1/9 Cluster-8309.33174 BP_3 2234.29 23.83 4811 478254660 ENN74901.1 1230 7.4e-132 hypothetical protein YQE_08479, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12109 CXCR4 Chemokine receptor N terminal -- -- GO:0019955 cytokine binding -- -- -- -- Cluster-8309.33178 BP_3 29.00 0.36 4145 766918859 XP_011500740.1 184 1.2e-10 PREDICTED: zinc finger protein 534-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- Q7KQZ4 159 4.0e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF02176//PF00096 TRAF-type zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.33179 BP_3 75.01 4.42 1110 642931814 XP_008196744.1 1242 6.9e-134 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 894 6.4e-95 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF06584//PF00067 DIRP//Cytochrome P450 GO:0006351//GO:0007049//GO:0055114 transcription, DNA-templated//cell cycle//oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding GO:0017053 transcriptional repressor complex -- -- Cluster-8309.3318 BP_3 16.37 0.83 1247 642929001 XP_008195650.1 501 6.5e-48 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- K08630 ADAMTS16 a disintegrin and metalloproteinase with thrombospondin motifs 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08630 Q8TE57 236 1.4e-18 A disintegrin and metalloproteinase with thrombospondin motifs 16 OS=Homo sapiens GN=ADAMTS16 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33180 BP_3 580.54 25.34 1396 642930414 XP_008196390.1 760 6.8e-78 PREDICTED: BAG family molecular chaperone regulator 2 [Tribolium castaneum]>gi|270009406|gb|EFA05854.1| hypothetical protein TcasGA2_TC008649 [Tribolium castaneum] -- -- -- -- -- K09556 BAG2 BCL2-associated athanogene 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09556 Q91YN9 304 2.1e-26 BAG family molecular chaperone regulator 2 OS=Mus musculus GN=Bag2 PE=1 SV=1 PF06005 Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly -- -- GO:0005737 cytoplasm KOG3633 BAG family molecular chaperone regulator 2 Cluster-8309.33181 BP_3 50.41 2.16 1417 642930414 XP_008196390.1 488 2.4e-46 PREDICTED: BAG family molecular chaperone regulator 2 [Tribolium castaneum]>gi|270009406|gb|EFA05854.1| hypothetical protein TcasGA2_TC008649 [Tribolium castaneum] -- -- -- -- -- K09556 BAG2 BCL2-associated athanogene 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09556 Q91YN9 217 2.6e-16 BAG family molecular chaperone regulator 2 OS=Mus musculus GN=Bag2 PE=1 SV=1 PF01544 CorA-like Mg2+ transporter protein GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG3633 BAG family molecular chaperone regulator 2 Cluster-8309.33182 BP_3 803.36 4.16 9602 91091742 XP_966408.1 1295 4.3e-139 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 953 8.0e-101 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF03431//PF02424//PF05372//PF00202 RNA replicase, beta-chain//ApbE family//Delta lysin family//Aminotransferase class-III GO:0006144//GO:0019079//GO:0008152//GO:0017013//GO:0019836 purine nucleobase metabolic process//viral genome replication//metabolic process//protein flavinylation//hemolysis by symbiont of host erythrocytes GO:0030170//GO:0008483//GO:0003968 pyridoxal phosphate binding//transaminase activity//RNA-directed RNA polymerase activity GO:0031379//GO:0005576 RNA-directed RNA polymerase complex//extracellular region KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.33183 BP_3 73.82 0.51 7311 642911280 XP_008199354.1 1164 5.1e-124 PREDICTED: glutamate-gated chloride channel isoform X4 [Tribolium castaneum] 462373324 APGK01024787.1 67 1.89503e-23 Dendroctonus ponderosae Seq01024797, whole genome shotgun sequence K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 1000 2.2e-106 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.33184 BP_3 201.93 2.76 3823 642936594 XP_008198499.1 1421 4.2e-154 PREDICTED: solute carrier family 2, facilitated glucose transporter member 1-like isoform X2 [Tribolium castaneum]>gi|270014149|gb|EFA10597.1| hypothetical protein TcasGA2_TC012857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13355 670 2.1e-68 Solute carrier family 2, facilitated glucose transporter member 1 OS=Oryctolagus cuniculus GN=SLC2A1 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.33185 BP_3 15.00 1.17 910 -- -- -- -- -- 817197946 XM_012419174.1 34 5.05075e-06 PREDICTED: Orussus abietinus eukaryotic initiation factor 4A-I (LOC105696595), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33186 BP_3 332.59 7.38 2465 91094219 XP_973249.1 584 3.1e-57 PREDICTED: uncharacterized protein C9orf85 homolog isoform X2 [Tribolium castaneum]>gi|270016216|gb|EFA12662.1| hypothetical protein TcasGA2_TC002245 [Tribolium castaneum] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q5TZ51 297 2.4e-25 Protein Mpv17 OS=Danio rerio GN=mpv17 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.33187 BP_3 6948.00 35.84 9636 642913145 XP_008201411.1 14553 0.0e+00 PREDICTED: uncharacterized protein LOC663838 isoform X1 [Tribolium castaneum] 642913144 XM_008203189.1 1767 0 PREDICTED: Tribolium castaneum uncharacterized LOC663838 (LOC663838), transcript variant X1, mRNA -- -- -- -- P10079 1340 1.1e-145 Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.33188 BP_3 218.00 23.03 748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33189 BP_3 620.00 26.68 1412 642913147 XP_008201412.1 1842 2.3e-203 PREDICTED: uncharacterized protein LOC663838 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLB4 254 1.3e-20 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF03146//PF00057 Agrin NtA domain//Low-density lipoprotein receptor domain class A GO:0043113//GO:0007213 receptor clustering//G-protein coupled acetylcholine receptor signaling pathway GO:0043236//GO:0005515 laminin binding//protein binding -- -- -- -- Cluster-8309.33191 BP_3 295.00 7.21 2263 642919122 XP_972010.2 1641 7.6e-180 PREDICTED: uncharacterized protein LOC660708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXT5 1126 1.6e-121 CWF19-like protein 2 homolog OS=Drosophila melanogaster GN=CG9213 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2477 Uncharacterized conserved protein Cluster-8309.33193 BP_3 3096.67 25.53 6137 91088413 XP_966659.1 6133 0.0e+00 PREDICTED: TATA-binding protein-associated factor 172 [Tribolium castaneum]>gi|270011757|gb|EFA08205.1| hypothetical protein TcasGA2_TC005832 [Tribolium castaneum] 347966666 XM_321235.5 345 4.59232e-178 Anopheles gambiae str. PEST AGAP001820-PA (AgaP_AGAP001820) mRNA, complete cds K15192 BTAF1, MOT1 TATA-binding protein-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15192 O14981 3145 0.0e+00 TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 PF00176//PF02985//PF02262//PF15247 SNF2 family N-terminal domain//HEAT repeat//CBL proto-oncogene N-terminal domain 1//Histone RNA hairpin-binding protein RNA-binding domain GO:0007166//GO:0007165 cell surface receptor signaling pathway//signal transduction GO:0004871//GO:0005515//GO:0003677//GO:0005524//GO:0003723//GO:0004386 signal transducer activity//protein binding//DNA binding//ATP binding//RNA binding//helicase activity GO:0005634 nucleus KOG0392 SNF2 family DNA-dependent ATPase domain-containing protein Cluster-8309.33194 BP_3 345.28 2.14 8079 91085649 XP_970922.1 6731 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum]>gi|270011037|gb|EFA07485.1| hypothetical protein TcasGA2_TC009375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R422 759 2.1e-78 CD109 antigen OS=Mus musculus GN=Cd109 PE=2 SV=1 PF07678//PF13639//PF01835//PF00432//PF02033//PF07677//PF00057//PF00207 A-macroglobulin complement component//Ring finger domain//MG2 domain//Prenyltransferase and squalene oxidase repeat//Ribosome-binding factor A//A-macroglobulin receptor//Low-density lipoprotein receptor domain class A//Alpha-2-macroglobulin family GO:0006364//GO:0010951 rRNA processing//negative regulation of endopeptidase activity GO:0008270//GO:0004866//GO:0005515//GO:0003824 zinc ion binding//endopeptidase inhibitor activity//protein binding//catalytic activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.33195 BP_3 1104.36 8.48 6571 91088413 XP_966659.1 4714 0.0e+00 PREDICTED: TATA-binding protein-associated factor 172 [Tribolium castaneum]>gi|270011757|gb|EFA08205.1| hypothetical protein TcasGA2_TC005832 [Tribolium castaneum] 831521961 XM_012862362.1 239 4.13761e-119 PREDICTED: Fundulus heteroclitus BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (btaf1), mRNA K15192 BTAF1, MOT1 TATA-binding protein-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15192 O14981 2080 1.1e-231 TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 PF00176//PF02985//PF07571//PF02262 SNF2 family N-terminal domain//HEAT repeat//TAF6 C-terminal HEAT repeat domain//CBL proto-oncogene N-terminal domain 1 GO:0007166//GO:0051090//GO:0007165 cell surface receptor signaling pathway//regulation of sequence-specific DNA binding transcription factor activity//signal transduction GO:0004871//GO:0005515//GO:0003677//GO:0005524//GO:0004386 signal transducer activity//protein binding//DNA binding//ATP binding//helicase activity GO:0005634 nucleus KOG0392 SNF2 family DNA-dependent ATPase domain-containing protein Cluster-8309.33197 BP_3 359.89 3.34 5484 642933562 XP_008197472.1 1789 1.3e-196 PREDICTED: serine-enriched protein isoform X5 [Tribolium castaneum] 642933561 XM_008199250.1 510 0 PREDICTED: Tribolium castaneum serine-enriched protein (LOC100142243), transcript variant X5, mRNA -- -- -- -- O61366 1469 6.7e-161 Serine-enriched protein OS=Drosophila melanogaster GN=gprs PE=3 SV=3 PF02214//PF00651 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.33198 BP_3 10.51 0.91 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33199 BP_3 500.46 16.61 1744 646716704 KDR19844.1 661 2.6e-66 hypothetical protein L798_05910 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W440 592 1.1e-59 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.332 BP_3 11.00 0.41 1577 270015294 EFA11742.1 759 1.0e-77 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3320 BP_3 2.00 1.10 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33200 BP_3 2.00 1.90 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33201 BP_3 155.58 0.88 8842 642917305 XP_008199244.1 6926 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X5 [Tribolium castaneum] 665815961 XM_008558446.1 643 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3643 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF06464//PF02710//PF02784//PF00501 DMAP1-binding Domain//Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein//Pyridoxal-dependent decarboxylase, pyridoxal binding domain//AMP-binding enzyme GO:0019064//GO:0007165//GO:0008152 fusion of virus membrane with host plasma membrane//signal transduction//metabolic process GO:0008134//GO:0003824//GO:0016788//GO:0046789 transcription factor binding//catalytic activity//hydrolase activity, acting on ester bonds//host cell surface receptor binding GO:0005667//GO:0019031//GO:0005634//GO:0009986 transcription factor complex//viral envelope//nucleus//cell surface KOG3628 Predicted AMP-binding protein Cluster-8309.33202 BP_3 1762.86 22.91 4001 642911681 XP_008200699.1 3110 0.0e+00 PREDICTED: stAR-related lipid transfer protein 13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q923Q2 1160 3.3e-125 StAR-related lipid transfer protein 13 OS=Mus musculus GN=Stard13 PE=1 SV=5 PF03121//PF00620//PF07647//PF01852 Herpesviridae UL52/UL70 DNA primase//RhoGAP domain//SAM domain (Sterile alpha motif)//START domain GO:0006351//GO:0007165//GO:0006269//GO:0006260 transcription, DNA-templated//signal transduction//DNA replication, synthesis of RNA primer//DNA replication GO:0008289//GO:0003896//GO:0005515 lipid binding//DNA primase activity//protein binding GO:0005657//GO:0005730 replication fork//nucleolus KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 Cluster-8309.33203 BP_3 16.00 0.48 1909 642912793 XP_972568.2 1791 2.6e-197 PREDICTED: uncharacterized protein LOC661310 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 B3A0N5 1334 1.1e-145 Apyrase OS=Tabanus yao PE=1 SV=1 PF00149//PF02872 Calcineurin-like phosphoesterase//5'-nucleotidase, C-terminal domain GO:0009166 nucleotide catabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.33204 BP_3 7.00 1.94 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.33205 BP_3 13.14 0.60 1341 642937480 XP_008198856.1 211 3.0e-14 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08254//PF01006 Threonine leader peptide//Hepatitis C virus non-structural protein NS4a GO:0031554//GO:0031556//GO:0009088//GO:0016032 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome//threonine biosynthetic process//viral process -- -- GO:0019012 virion -- -- Cluster-8309.33207 BP_3 320.71 2.64 6148 642935825 XP_008198191.1 5274 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum]>gi|642935827|ref|XP_008198192.1| PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum]>gi|642935829|ref|XP_008198193.1| PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 4.3e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.33208 BP_3 152.89 6.70 1392 91079436 XP_968348.1 1081 4.0e-115 PREDICTED: solute carrier family 25 member 35 [Tribolium castaneum]>gi|270004397|gb|EFA00845.1| hypothetical protein TcasGA2_TC003733 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 A3KPP4 787 2.1e-82 Solute carrier family 25 member 35 OS=Danio rerio GN=slc25a35 PE=2 SV=1 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.33212 BP_3 622.94 6.40 4983 349584990 BAL03255.1 1077 4.2e-114 93 kDa serpin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JJ64 477 6.5e-46 Uncharacterized serpin-like protein TK1782 OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=TK1782 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33218 BP_3 2075.35 19.29 5477 642926494 XP_008191978.1 1005 1.0e-105 PREDICTED: ribosomal RNA processing protein 1 homolog [Tribolium castaneum] -- -- -- -- -- K14849 RRP1 ribosomal RNA-processing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14849 Q9VJZ7 595 1.5e-59 Ribosomal RNA processing protein 1 homolog OS=Drosophila melanogaster GN=Nnp-1 PE=1 SV=1 PF02865//PF04614//PF05997//PF01347//PF00435 STAT protein, protein interaction domain//Pex19 protein family//Nucleolar protein,Nop52//Lipoprotein amino terminal region//Spectrin repeat GO:0006364//GO:0006355//GO:0007165//GO:0006869 rRNA processing//regulation of transcription, DNA-templated//signal transduction//lipid transport GO:0004871//GO:0003700//GO:0005515//GO:0005319 signal transducer activity//transcription factor activity, sequence-specific DNA binding//protein binding//lipid transporter activity GO:0030688//GO:0005667//GO:0005777 preribosome, small subunit precursor//transcription factor complex//peroxisome KOG3911 Nucleolar protein NOP52/RRP1 Cluster-8309.33219 BP_3 62.25 0.70 4552 642939310 XP_008200401.1 1203 9.4e-129 PREDICTED: tRNA (guanine(37)-N1)-methyltransferase [Tribolium castaneum] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 942 7.1e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF08241//PF08245//PF14750//PF09445//PF02875//PF02086 Methyltransferase domain//Mur ligase middle domain//Integrator complex subunit 2//RNA cap guanine-N2 methyltransferase//Mur ligase family, glutamate ligase domain//D12 class N6 adenine-specific DNA methyltransferase GO:0006306//GO:0009058//GO:0001510//GO:0032775//GO:0009452//GO:0008152 DNA methylation//biosynthetic process//RNA methylation//DNA methylation on adenine//7-methylguanosine RNA capping//metabolic process GO:0008168//GO:0009007//GO:0005524//GO:0016874 methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//ATP binding//ligase activity GO:0032039 integrator complex KOG2525 Folylpolyglutamate synthase Cluster-8309.33220 BP_3 1501.00 12.85 5922 91079969 XP_969838.1 970 1.3e-101 PREDICTED: beta-1,3-galactosyltransferase 5 [Tribolium castaneum]>gi|270004605|gb|EFA01053.1| hypothetical protein TcasGA2_TC003969 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N293 329 1.1e-28 Beta-1,3-galactosyltransferase 5 (Fragment) OS=Gorilla gorilla gorilla GN=B3GALT5 PE=3 SV=2 PF00119//PF13762//PF01762 ATP synthase A chain//Mitochondrial splicing apparatus component//Galactosyltransferase GO:0000372//GO:0006486//GO:0015986//GO:0015992 Group I intron splicing//protein glycosylation//ATP synthesis coupled proton transport//proton transport GO:0016740//GO:0015078//GO:0008378 transferase activity//hydrogen ion transmembrane transporter activity//galactosyltransferase activity GO:0030529//GO:0016020 intracellular ribonucleoprotein complex//membrane -- -- Cluster-8309.33221 BP_3 258.17 17.04 1022 546676446 ERL87451.1 215 7.8e-15 hypothetical protein D910_04843 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33222 BP_3 86.32 1.18 3828 642937984 XP_008199157.1 261 1.4e-19 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 178 2.3e-11 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 PF00957//PF07535//PF08294 Synaptobrevin//DBF zinc finger//TIM21 GO:0030150//GO:0016192 protein import into mitochondrial matrix//vesicle-mediated transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005744//GO:0016021 mitochondrial inner membrane presequence translocase complex//integral component of membrane KOG1362 Choline transporter-like protein Cluster-8309.33223 BP_3 665.46 18.86 1992 642937984 XP_008199157.1 347 7.5e-30 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 161 1.1e-09 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33225 BP_3 232.70 3.35 3643 347966510 XP_321327.5 366 8.6e-32 AGAP001756-PA [Anopheles gambiae str. PEST]>gi|333470028|gb|EAA01239.5| AGAP001756-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- A5PK40 287 5.1e-24 Choline transporter-like protein 3 OS=Bos taurus GN=SLC44A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.33228 BP_3 587.00 12.81 2501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33229 BP_3 70.00 1.79 2178 270001300 EEZ97747.1 413 1.8e-37 nimrod A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 214 8.9e-16 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF07546 EMI domain -- -- GO:0005515 protein binding -- -- KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.33230 BP_3 9761.00 151.51 3397 91086973 XP_973336.1 1777 1.9e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 1048 2.7e-112 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF02254//PF00732//PF07992//PF05834 GMC oxidoreductase//TrkA-N domain//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein GO:0006813//GO:0055114//GO:0016117 potassium ion transport//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016705//GO:0016614 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.33233 BP_3 386.39 2.93 6638 91090320 XP_972446.1 2561 4.7e-286 PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|642934930|ref|XP_008197867.1| PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|270013809|gb|EFA10257.1| hypothetical protein TcasGA2_TC012457 [Tribolium castaneum] 642934931 XR_511636.1 696 0 PREDICTED: Tribolium castaneum rho-related BTB domain-containing protein 2 (LOC661174), transcript variant X2, misc_RNA K07868 RHOBTB1_2 Rho-related BTB domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07868 Q9DAK3 906 1.6e-95 Rho-related BTB domain-containing protein 1 OS=Mus musculus GN=Rhobtb1 PE=1 SV=2 PF08477//PF00651//PF00071 Ras of Complex, Roc, domain of DAPkinase//BTB/POZ domain//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005515//GO:0005525 protein binding//GTP binding GO:0005622 intracellular -- -- Cluster-8309.33238 BP_3 33.29 2.68 890 642912272 XP_008200632.1 281 1.5e-22 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTZ1 125 7.6e-06 Ovochymase-2 OS=Homo sapiens GN=OVCH2 PE=3 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.3324 BP_3 1.00 0.33 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33240 BP_3 682.00 19.59 1970 572316441 XP_006623846.1 481 2.1e-45 PREDICTED: serine proteinase stubble-like isoform X1 [Apis dorsata]>gi|572316443|ref|XP_006623847.1| PREDICTED: serine proteinase stubble-like isoform X2 [Apis dorsata] -- -- -- -- -- -- -- -- -- Q2KJ63 275 6.8e-23 Plasma kallikrein OS=Bos taurus GN=KLKB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33241 BP_3 674.35 9.80 3607 546679553 ERL90001.1 1213 5.2e-130 hypothetical protein D910_07360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08283 Geminivirus rep protein central domain GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.33242 BP_3 24.99 0.55 2480 642916405 XP_008191009.1 615 7.8e-61 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GMN2 183 4.0e-12 Brain-specific angiogenesis inhibitor 1-associated protein 2 OS=Rattus norvegicus GN=Baiap2 PE=1 SV=1 PF03114//PF08397 BAR domain//IRSp53/MIM homology domain GO:0007009 plasma membrane organization GO:0005515 protein binding GO:0005737 cytoplasm -- -- Cluster-8309.33243 BP_3 149.22 1.10 6859 642916405 XP_008191009.1 2357 2.2e-262 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.8e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF00018//PF14604//PF03114//PF09360 IRSp53/MIM homology domain//SH3 domain//Variant SH3 domain//BAR domain//Iron-binding zinc finger CDGSH type GO:0007009 plasma membrane organization GO:0005515//GO:0051537 protein binding//2 iron, 2 sulfur cluster binding GO:0005737//GO:0043231 cytoplasm//intracellular membrane-bounded organelle -- -- Cluster-8309.33244 BP_3 801.91 5.79 6966 642916405 XP_008191009.1 2357 2.2e-262 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.8e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF03114//PF09360//PF00018//PF14604 IRSp53/MIM homology domain//BAR domain//Iron-binding zinc finger CDGSH type//SH3 domain//Variant SH3 domain GO:0007009 plasma membrane organization GO:0005515//GO:0051537 protein binding//2 iron, 2 sulfur cluster binding GO:0005737//GO:0043231 cytoplasm//intracellular membrane-bounded organelle -- -- Cluster-8309.33246 BP_3 112.56 0.62 9111 642911061 XP_008200558.1 3908 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 575 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2828 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00520//PF00813//PF00057 Ion transport protein//FliP family//Low-density lipoprotein receptor domain class A GO:0055085//GO:0009306//GO:0006811 transmembrane transport//protein secretion//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.33248 BP_3 23.51 0.75 1795 91090210 XP_967762.1 1509 1.2e-164 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9XT55 625 1.6e-63 UDP-glucuronosyltransferase 2B19 OS=Macaca fascicularis GN=UGT2B19 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016740//GO:0016758 transferase activity//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.33251 BP_3 304.73 1.73 8789 817054227 XP_012266426.1 1648 4.6e-180 PREDICTED: phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1 [Athalia rosae] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA -- -- -- -- Q5ZL26 1288 1.0e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF14572//PF00156 Phosphoribosyl synthetase-associated domain//Phosphoribosyl transferase domain GO:0006098//GO:0009116//GO:0006144//GO:0009165 pentose-phosphate shunt//nucleoside metabolic process//purine nucleobase metabolic process//nucleotide biosynthetic process GO:0004749//GO:0000287 ribose phosphate diphosphokinase activity//magnesium ion binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.33253 BP_3 960.86 17.72 2906 642913255 XP_008201459.1 819 2.0e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 6.87057e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.3e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.33256 BP_3 3.00 0.43 630 91080173 XP_970371.1 229 1.1e-16 PREDICTED: cytochrome b-c1 complex subunit 8 [Tribolium castaneum]>gi|270006414|gb|EFA02862.1| ubiquinol-cytochrome c reductase, complex III subunit VII [Tribolium castaneum] -- -- -- -- -- K00418 QCR8, UQCRQ ubiquinol-cytochrome c reductase subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K00418 Q2L897 146 2.0e-08 Cytochrome b-c1 complex subunit 8 OS=Ailuropoda melanoleuca GN=UQCRQ PE=3 SV=3 PF02939 UcrQ family GO:0015992//GO:0006119//GO:0006118 proton transport//oxidative phosphorylation//obsolete electron transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.33258 BP_3 27.00 15.15 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33260 BP_3 497.63 7.46 3507 642933032 XP_008197237.1 2247 6.4e-250 PREDICTED: serine/threonine-protein kinase unc-51 isoform X2 [Tribolium castaneum] 820865549 XM_003698790.2 61 1.95802e-20 PREDICTED: Apis florea serine/threonine-protein kinase unc-51 (LOC100864929), transcript variant X1, mRNA K08269 ULK1_2_3, ATG1 serine/threonine-protein kinase ULK/ATG1 http://www.genome.jp/dbget-bin/www_bget?ko:K08269 Q8IYT8 913 1.3e-96 Serine/threonine-protein kinase ULK2 OS=Homo sapiens GN=ULK2 PE=1 SV=3 PF00069//PF06293//PF07714//PF12063 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Domain of unknown function (DUF3543) GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0595 Serine/threonine-protein kinase involved in autophagy Cluster-8309.33261 BP_3 435.67 28.68 1024 91090900 XP_973581.1 767 7.7e-79 PREDICTED: peroxisomal membrane protein PMP22 [Tribolium castaneum]>gi|270013225|gb|EFA09673.1| hypothetical protein TcasGA2_TC011801 [Tribolium castaneum] -- -- -- -- -- K13347 PXMP2, PMP22 peroxisomal membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13347 Q9ZS51 231 4.5e-18 Peroxisomal membrane protein PMP22 OS=Arabidopsis thaliana GN=PMP22 PE=1 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.33262 BP_3 361.97 15.94 1386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33263 BP_3 134.04 8.13 1086 270012506 EFA08954.1 1063 3.9e-113 hypothetical protein TcasGA2_TC006661 [Tribolium castaneum] 768434472 XM_011560346.1 38 3.62476e-08 PREDICTED: Plutella xylostella atrial natriuretic peptide receptor 1 (LOC105389255), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P16066 622 2.2e-63 Atrial natriuretic peptide receptor 1 OS=Homo sapiens GN=NPR1 PE=1 SV=1 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.33264 BP_3 1922.69 43.00 2447 642932067 XP_008196844.1 2877 0.0e+00 PREDICTED: actin-interacting protein 1 [Tribolium castaneum]>gi|270011670|gb|EFA08118.1| hypothetical protein TcasGA2_TC005722 [Tribolium castaneum] 755951689 XM_011303542.1 201 2.03378e-98 PREDICTED: Fopius arisanus actin-interacting protein 1 (LOC105265810), mRNA -- -- -- -- Q9VU68 2356 4.2e-264 Actin-interacting protein 1 OS=Drosophila melanogaster GN=flr PE=2 SV=1 PF04053//PF03178//PF00400 Coatomer WD associated region//CPSF A subunit region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198//GO:0003676 protein binding//structural molecule activity//nucleic acid binding GO:0030117//GO:0005634 membrane coat//nucleus KOG0318 WD40 repeat stress protein/actin interacting protein Cluster-8309.33265 BP_3 238.76 4.92 2630 91089737 XP_975124.1 1653 3.6e-181 PREDICTED: protein RFT1 homolog [Tribolium castaneum]>gi|270011306|gb|EFA07754.1| hypothetical protein TcasGA2_TC005308 [Tribolium castaneum] -- -- -- -- -- K06316 RFT1 oligosaccharide translocation protein RFT1 http://www.genome.jp/dbget-bin/www_bget?ko:K06316 Q9Y123 1075 1.6e-115 Protein RFT1 homolog OS=Drosophila melanogaster GN=CG3149 PE=2 SV=1 PF01384//PF04506 Phosphate transporter family//Rft protein GO:0006817//GO:0006869 phosphate ion transport//lipid transport GO:0005319//GO:0005315 lipid transporter activity//inorganic phosphate transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.33266 BP_3 587.00 10.39 3016 644993549 XP_008213019.1 157 1.2e-07 PREDICTED: probable phospholipid-transporting ATPase IA isoform X3 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33268 BP_3 95.52 1.00 4888 642931172 XP_008196469.1 2267 4.3e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33269 BP_3 1012.41 8.79 5842 642931172 XP_008196469.1 2267 5.1e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33270 BP_3 586.15 9.98 3123 478250396 ENN70891.1 1074 5.9e-114 hypothetical protein YQE_12296, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8AWW5 248 1.5e-19 Cysteine-rich motor neuron 1 protein OS=Gallus gallus GN=CRIM1 PE=2 SV=1 PF02822//PF00093 Antistasin family//von Willebrand factor type C domain -- -- GO:0004867//GO:0005515 serine-type endopeptidase inhibitor activity//protein binding -- -- KOG1216 von Willebrand factor and related coagulation proteins Cluster-8309.33272 BP_3 669.40 6.69 5112 642921170 XP_008192744.1 2383 1.6e-265 PREDICTED: ATP-binding cassette sub-family B member 10, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K05657 ABCB10 ATP-binding cassette, subfamily B (MDR/TAP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05657 Q9NRK6 1543 1.6e-169 ATP-binding cassette sub-family B member 10, mitochondrial OS=Homo sapiens GN=ABCB10 PE=1 SV=2 PF14991//PF07728//PF13304//PF00664//PF03193//PF10288//PF00005//PF06414 Protein melan-A//AAA domain (dynein-related subfamily)//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//Cytoplasmic tRNA 2-thiolation protein 2//ABC transporter//Zeta toxin GO:0006810//GO:0002098//GO:0055085//GO:0034227 transport//tRNA wobble uridine modification//transmembrane transport//tRNA thio-modification GO:0042626//GO:0016301//GO:0016887//GO:0005525//GO:0000049//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//GTP binding//tRNA binding//GTPase activity//ATP binding GO:0042470//GO:0016021 melanosome//integral component of membrane KOG0058 Peptide exporter, ABC superfamily Cluster-8309.33274 BP_3 177.56 1.48 6079 642914773 XP_008190345.1 1450 2.9e-157 PREDICTED: protein SERAC1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SNQ7 389 1.3e-35 Protein SERAC1 OS=Danio rerio GN=serac1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33275 BP_3 5517.82 57.90 4885 24646906 NP_731941.1 804 1.9e-82 effete, isoform A [Drosophila melanogaster]>gi|187117170|ref|NP_001119686.1| effete [Acyrthosiphon pisum]>gi|442619106|ref|NP_001262578.1| effete, isoform B [Drosophila melanogaster]>gi|442619108|ref|NP_001262579.1| effete, isoform C [Drosophila melanogaster]>gi|58381090|ref|XP_310998.2| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|91077526|ref|XP_970430.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Tribolium castaneum]>gi|156550189|ref|XP_001605481.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Nasonia vitripennis]>gi|157134117|ref|XP_001663154.1| AAEL003103-PA [Aedes aegypti]>gi|194743322|ref|XP_001954149.1| GF18131 [Drosophila ananassae]>gi|194900836|ref|XP_001979961.1| GG21088 [Drosophila erecta]>gi|195061220|ref|XP_001995948.1| GH14086 [Drosophila grimshawi]>gi|195113175|ref|XP_002001144.1| GI10619 [Drosophila mojavensis]>gi|195143851|ref|XP_002012910.1| GL23670 [Drosophila persimilis]>gi|195328929|ref|XP_002031164.1| GM25828 [Drosophila sechellia]>gi|195390905|ref|XP_002054107.1| GJ22971 [Drosophila virilis]>gi|195444200|ref|XP_002069759.1| GK11688 [Drosophila willistoni]>gi|195501528|ref|XP_002097834.1| eff [Drosophila yakuba]>gi|195570846|ref|XP_002103415.1| GD20402 [Drosophila simulans]>gi|198451027|ref|XP_002137205.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|498939690|ref|XP_004521259.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|498939696|ref|XP_004521261.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|557775059|ref|XP_005187176.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Musca domestica]>gi|746860060|ref|XP_011060857.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Acromyrmex echinatior]>gi|749733753|ref|XP_011147642.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Harpegnathos saltator]>gi|751469127|ref|XP_011189731.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera cucurbitae]>gi|751776279|ref|XP_011214825.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|751776281|ref|XP_011214826.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|755991226|ref|XP_011312803.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Fopius arisanus]>gi|759038025|ref|XP_011351525.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Cerapachys biroi]>gi|766937511|ref|XP_011501212.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratosolen solmsi marchali]>gi|769846059|ref|XP_011634316.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Pogonomyrmex barbatus]>gi|780635308|ref|XP_011686505.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Wasmannia auropunctata]>gi|795091706|ref|XP_011879556.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Vollenhovia emeryi]>gi|801395562|ref|XP_012058392.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Atta cephalotes]>gi|815791114|ref|XP_012216125.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Linepithema humile]>gi|817074138|ref|XP_012259245.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Athalia rosae]>gi|817201924|ref|XP_012276729.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Orussus abietinus]>gi|826426802|ref|XP_012527496.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Monomorium pharaonis]>gi|136643|sp|P25867.1|UBCD1_DROME RecName: Full=Ubiquitin-conjugating enzyme E2-17 kDa; AltName: Full=Protein effete; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-protein ligase>gi|8783|emb|CAA44453.1| ubiquitin-conjugating enzyme [Drosophila melanogaster]>gi|7299919|gb|AAF55093.1| effete, isoform A [Drosophila melanogaster]>gi|16648156|gb|AAL25343.1| GH14739p [Drosophila melanogaster]>gi|46561756|gb|AAT01083.1| putative ubiquitin-conjugating enzyme [Homalodisca vitripennis]>gi|55243675|gb|EAA06420.3| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|89473748|gb|ABD72686.1| putative ubiquitin-conjugating enzyme [Acyrthosiphon pisum]>gi|94468952|gb|ABF18325.1| ubiquitin-conjugating enzyme [Aedes aegypti]>gi|108881406|gb|EAT45631.1| AAEL003103-PA [Aedes aegypti]>gi|190627186|gb|EDV42710.1| GF18131 [Drosophila ananassae]>gi|190651664|gb|EDV48919.1| GG21088 [Drosophila erecta]>gi|193891740|gb|EDV90606.1| GH14086 [Drosophila grimshawi]>gi|193917738|gb|EDW16605.1| GI10619 [Drosophila mojavensis]>gi|194101853|gb|EDW23896.1| GL23670 [Drosophila persimilis]>gi|194120107|gb|EDW42150.1| GM25828 [Drosophila sechellia]>gi|194152193|gb|EDW67627.1| GJ22971 [Drosophila virilis]>gi|194165844|gb|EDW80745.1| GK11688 [Drosophila willistoni]>gi|194183935|gb|EDW97546.1| eff [Drosophila yakuba]>gi|194199342|gb|EDX12918.1| GD20402 [Drosophila simulans]>gi|198131302|gb|EDY67763.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|220945198|gb|ACL85142.1| eff-PA, partial [synthetic construct]>gi|220955014|gb|ACL90050.1| eff-PA [synthetic construct]>gi|239791033|dbj|BAH72034.1| ACYPI000078 [Acyrthosiphon pisum]>gi|270002752|gb|EEZ99199.1| effete [Tribolium castaneum]>gi|332375666|gb|AEE62974.1| unknown [Dendroctonus ponderosae]>gi|440217433|gb|AGB95959.1| effete, isoform B [Drosophila melanogaster]>gi|440217434|gb|AGB95960.1| effete, isoform C [Drosophila melanogaster]>gi|478262539|gb|ENN81177.1| hypothetical protein YQE_02422, partial [Dendroctonus ponderosae]>gi|546683237|gb|ERL93069.1| hypothetical protein D910_10371 [Dendroctonus ponderosae]>gi|646714335|gb|KDR18345.1| Ubiquitin-conjugating enzyme E2-17 kDa [Zootermopsis nevadensis]>gi|861642908|gb|KMQ94120.1| ubiquitin-conjugating enzyme [Lasius niger]>gi|900914055|gb|KMZ03557.1| uncharacterized protein Dsimw501_GD20402 [Drosophila simulans] 642914089 XM_965337.3 556 0 PREDICTED: Tribolium castaneum effete (LOC658996), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P25867 804 7.7e-84 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=eff PE=2 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0015031//GO:0007067//GO:0007140//GO:0030718//GO:0045676//GO:0048132//GO:0006464//GO:0016322//GO:0031647//GO:0007286//GO:0008054//GO:0016567//GO:0051276 protein transport//mitotic nuclear division//male meiosis//germ-line stem cell population maintenance//regulation of R7 cell differentiation//female germ-line stem cell asymmetric division//cellular protein modification process//neuron remodeling//regulation of protein stability//spermatid development//negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation//protein ubiquitination//chromosome organization GO:0005524//GO:0004842//GO:0005515 ATP binding//ubiquitin-protein transferase activity//protein binding GO:0005875 microtubule associated complex KOG0417 Ubiquitin-protein ligase Cluster-8309.33276 BP_3 44.68 2.73 1082 189239183 XP_966847.2 761 4.0e-78 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q7KT91 626 7.4e-64 Non-lysosomal glucosylceramidase OS=Drosophila melanogaster GN=CG33090 PE=1 SV=1 PF01204//PF04685 Trehalase//Protein of unknown function, DUF608 GO:0005991//GO:0006665//GO:0005985//GO:0005982//GO:0005975//GO:0006687//GO:0006680//GO:0006807 trehalose metabolic process//sphingolipid metabolic process//sucrose metabolic process//starch metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//glucosylceramide catabolic process//nitrogen compound metabolic process GO:0004555//GO:0004348 alpha,alpha-trehalase activity//glucosylceramidase activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.33277 BP_3 202.53 4.51 2457 123227460 CAM27169.1 250 1.6e-18 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] -- -- -- -- -- K09194 SP4 transcription factor Sp4 http://www.genome.jp/dbget-bin/www_bget?ko:K09194 Q8TC21 239 1.3e-18 Zinc finger protein 596 OS=Homo sapiens GN=ZNF596 PE=2 SV=2 PF13465//PF00096//PF00993//PF01644//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Class II histocompatibility antigen, alpha domain//Chitin synthase//C2H2-type zinc finger GO:0006031//GO:0019882//GO:0006955 chitin biosynthetic process//antigen processing and presentation//immune response GO:0046872//GO:0004100 metal ion binding//chitin synthase activity GO:0042613//GO:0016020 MHC class II protein complex//membrane -- -- Cluster-8309.33278 BP_3 82.31 2.21 2090 91089709 XP_974931.1 354 1.2e-30 PREDICTED: eukaryotic translation initiation factor 4E-binding protein 2 [Tribolium castaneum]>gi|270012640|gb|EFA09088.1| hypothetical protein TcasGA2_TC006808 [Tribolium castaneum] -- -- -- -- -- K18644 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18644 P56649 235 3.1e-18 Glyceraldehyde-3-phosphate dehydrogenase OS=Panulirus versicolor PE=1 SV=1 PF05456//PF02800//PF02768//PF09771//PF00044 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//DNA polymerase III beta subunit, C-terminal domain//Transmembrane protein 188//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0035307//GO:0045947//GO:0006260//GO:0055114 positive regulation of protein dephosphorylation//negative regulation of translational initiation//DNA replication//oxidation-reduction process GO:0003677//GO:0003887//GO:0008408//GO:0016620//GO:0008190 DNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//eukaryotic initiation factor 4E binding GO:0009360//GO:0042575//GO:0071595 DNA polymerase III complex//DNA polymerase complex//Nem1-Spo7 phosphatase complex KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.33279 BP_3 115.35 2.81 2269 91079828 XP_970042.1 661 3.3e-66 PREDICTED: aprataxin [Tribolium castaneum]>gi|642918234|ref|XP_008191423.1| PREDICTED: aprataxin [Tribolium castaneum]>gi|270004538|gb|EFA00986.1| hypothetical protein TcasGA2_TC003899 [Tribolium castaneum] -- -- -- -- -- K10863 APTX aprataxin http://www.genome.jp/dbget-bin/www_bget?ko:K10863 P61799 437 1.3e-41 Aprataxin OS=Danio rerio GN=aptx PE=2 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG0562 Predicted hydrolase (HIT family) Cluster-8309.33280 BP_3 1198.00 29.88 2224 91083597 XP_968968.1 941 1.1e-98 PREDICTED: Golgi reassembly-stacking protein 2 [Tribolium castaneum]>gi|270007834|gb|EFA04282.1| hypothetical protein TcasGA2_TC014572 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99JX3 799 1.3e-83 Golgi reassembly-stacking protein 2 OS=Mus musculus GN=Gorasp2 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3834 Golgi reassembly stacking protein GRASP65, contains PDZ domain Cluster-8309.33281 BP_3 1397.51 11.60 6100 546675274 ERL86510.1 3807 0.0e+00 hypothetical protein D910_03914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR5 714 2.6e-73 GTPase-activating protein and VPS9 domain-containing protein 1 OS=Mus musculus GN=Gapvd1 PE=1 SV=2 PF02881//PF00616 SRP54-type protein, helical bundle domain//GTPase-activator protein for Ras-like GTPase GO:0043087//GO:0006614 regulation of GTPase activity//SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.33282 BP_3 74.07 0.95 4035 642913258 XP_008201460.1 819 2.8e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 175 9.57331e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 1.0e-73 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.33283 BP_3 3466.68 65.49 2843 642913255 XP_008201459.1 819 2.0e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 6.71975e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.2e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF01024//PF16367//PF00076 Colicin pore forming domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding GO:0016021 integral component of membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.33286 BP_3 37.54 0.73 2767 478260541 ENN80244.1 467 1.3e-43 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 5.46305e-30 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q12974 310 8.4e-27 Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens GN=PTP4A2 PE=1 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.33287 BP_3 452.57 9.13 2680 91095137 XP_972151.1 803 1.3e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.26046e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.7e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.33288 BP_3 931.00 17.58 2844 91081701 XP_970909.1 655 2.1e-65 PREDICTED: uncharacterized protein LOC659516 [Tribolium castaneum]>gi|642921305|ref|XP_008192810.1| PREDICTED: uncharacterized protein LOC659516 [Tribolium castaneum]>gi|642921307|ref|XP_008192811.1| PREDICTED: uncharacterized protein LOC659516 [Tribolium castaneum]>gi|270006461|gb|EFA02909.1| PDGF- and VEGF-related factor 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- C0K3N1 137 9.9e-07 Snake venom vascular endothelial growth factor toxin barietin OS=Bitis arietans PE=1 SV=1 PF00341 PDGF/VEGF domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.33289 BP_3 30.26 0.35 4457 642937480 XP_008198856.1 273 6.4e-21 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33290 BP_3 43.64 0.33 6759 642937480 XP_008198856.1 248 7.7e-18 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33292 BP_3 1097.23 10.02 5571 642922760 XP_008193313.1 2754 1.6e-308 PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X2 [Tribolium castaneum] 751220523 XM_011165095.1 223 2.749e-110 PREDICTED: Solenopsis invicta RNA pseudouridylate synthase domain-containing protein 2-like (LOC105198399), transcript variant X3, mRNA -- -- -- -- Q8IZ73 1040 3.8e-111 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF00849//PF00951//PF13895 RNA pseudouridylate synthase//Arterivirus GL envelope glycoprotein//Immunoglobulin domain GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982//GO:0005515 RNA binding//pseudouridine synthase activity//protein binding GO:0019031 viral envelope KOG1919 RNA pseudouridylate synthases Cluster-8309.33293 BP_3 7152.77 75.58 4853 642913622 XP_008201092.1 2545 2.5e-284 PREDICTED: moesin/ezrin/radixin homolog 1 isoform X3 [Tribolium castaneum] 347964053 XM_003436981.1 595 0 Anopheles gambiae str. PEST AGAP000562-PB (MOEH_ANOGA) mRNA, complete cds K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 2316 3.6e-259 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF06456//PF03114//PF14604//PF00018//PF00769//PF02255//PF00887//PF05531 Arfaptin-like domain//BAR domain//Variant SH3 domain//SH3 domain//Ezrin/radixin/moesin family//PTS system, Lactose/Cellobiose specific IIA subunit//Acyl CoA binding protein//Nucleopolyhedrovirus P10 protein GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0000062//GO:0019904//GO:0008092//GO:0005515 fatty-acyl-CoA binding//protein domain specific binding//cytoskeletal protein binding//protein binding GO:0005737//GO:0019898//GO:0019028 cytoplasm//extrinsic component of membrane//viral capsid KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.33295 BP_3 571.05 8.89 3389 546682082 ERL92068.1 2477 1.3e-276 hypothetical protein D910_09390 [Dendroctonus ponderosae] -- -- -- -- -- K12487 GIT2 G protein-coupled receptor kinase interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12487 Q14161 1018 8.2e-109 ARF GTPase-activating protein GIT2 OS=Homo sapiens GN=GIT2 PE=1 SV=2 PF06005//PF01412//PF13851//PF10392//PF06156//PF13606//PF03836//PF00023//PF01166 Protein of unknown function (DUF904)//Putative GTPase activating protein for Arf//Growth-arrest specific micro-tubule binding//Golgi transport complex subunit 5//Protein of unknown function (DUF972)//Ankyrin repeat//RasGAP C-terminus//Ankyrin repeat//TSC-22/dip/bun family GO:0048870//GO:0006891//GO:0007264//GO:0043093//GO:0000917//GO:0006355//GO:0006260 cell motility//intra-Golgi vesicle-mediated transport//small GTPase mediated signal transduction//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of transcription, DNA-templated//DNA replication GO:0005515//GO:0005096//GO:0003700 protein binding//GTPase activator activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0031514//GO:0005737//GO:0017119 transcription factor complex//motile cilium//cytoplasm//Golgi transport complex KOG0818 GTPase-activating proteins of the GIT family Cluster-8309.33296 BP_3 329.93 4.32 3975 642940398 XP_008200546.1 1113 2.3e-118 PREDICTED: chitin deacetylase 5 isoform X7 [Tribolium castaneum] 642940399 XM_008202325.1 70 2.20635e-25 PREDICTED: Tribolium castaneum chitin deacetylase 5 (Cda5), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.33297 BP_3 1676.14 22.18 3934 91078996 XP_974675.1 1185 1.0e-126 PREDICTED: zinc transporter ZIP1 [Tribolium castaneum]>gi|270003679|gb|EFA00127.1| hypothetical protein TcasGA2_TC002943 [Tribolium castaneum] -- -- -- -- -- K14709 SLC39A1_2_3, ZIP1_2_3 solute carrier family 39 (zinc transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14709 P59889 292 1.5e-24 Zinc transporter ZIP1 OS=Danio rerio GN=slc39a1 PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0044765//GO:0055085 metal ion transport//single-organism transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.33298 BP_3 411.71 3.19 6512 642924598 XP_008194358.1 2023 1.1e-223 PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924600|ref|XP_008194359.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924602|ref|XP_008194360.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum] 827557233 XM_012694434.1 87 1.28571e-34 PREDICTED: Bombyx mori Rho-associated protein kinase (rock1), transcript variant X1, mRNA K17388 ROCK2 Rho-associated protein kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17388 M3TYT0 1033 2.9e-110 Rho-associated protein kinase 2 OS=Sus scrofa GN=ROCK2 PE=1 SV=1 PF08912//PF00130//PF01420//PF00769//PF04513 Rho Binding//Phorbol esters/diacylglycerol binding domain (C1 domain)//Type I restriction modification DNA specificity domain//Ezrin/radixin/moesin family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0006304//GO:0035556 DNA modification//intracellular signal transduction GO:0017048//GO:0005198//GO:0003677//GO:0008092 Rho GTPase binding//structural molecule activity//DNA binding//cytoskeletal protein binding GO:0005737//GO:0019031//GO:0019898//GO:0019028 cytoplasm//viral envelope//extrinsic component of membrane//viral capsid KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.33299 BP_3 649.00 6.79 4901 642921392 XP_008192848.1 1098 1.5e-116 PREDICTED: cell adhesion molecule 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03490//PF13895 Variant-surface-glycoprotein phospholipase C//Immunoglobulin domain GO:0006650 glycerophospholipid metabolic process GO:0005515//GO:0047396 protein binding//glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.33301 BP_3 1313.29 14.29 4722 91084835 XP_966560.1 1369 5.5e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 6.8e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00114//PF04142//PF08449//PF06027//PF00893//PF00892//PF13895 Pilin (bacterial filament)//Nucleotide-sugar transporter//UAA transporter family//Solute carrier family 35//Small Multidrug Resistance protein//EamA-like transporter family//Immunoglobulin domain GO:0008643//GO:0007155//GO:0006810//GO:0055085 carbohydrate transport//cell adhesion//transport//transmembrane transport GO:0005515//GO:0005351 protein binding//sugar:proton symporter activity GO:0016020//GO:0000139//GO:0009289//GO:0016021 membrane//Golgi membrane//pilus//integral component of membrane KOG3912 Predicted integral membrane protein Cluster-8309.33305 BP_3 416.84 27.70 1017 549438521 AGX25149.1 1278 4.2e-138 purple acid phosphatase-like protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- A5D6U8 929 5.1e-99 Iron/zinc purple acid phosphatase-like protein OS=Danio rerio GN=papl PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG1378 Purple acid phosphatase Cluster-8309.33308 BP_3 13.00 2.17 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33311 BP_3 253.93 57.88 503 157112956 XP_001657696.1 485 1.9e-46 AAEL000138-PA [Aedes aegypti]>gi|108884662|gb|EAT48887.1| AAEL000138-PA [Aedes aegypti] -- -- -- -- -- K03950 NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03950 Q02366 311 1.2e-27 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Bos taurus GN=NDUFA6 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3426 NADH:ubiquinone oxidoreductase, NDUFA6/B14 subunit Cluster-8309.33314 BP_3 1227.56 10.47 5944 642926801 XP_969339.3 2263 1.5e-251 PREDICTED: histone-lysine N-methyltransferase SETD1B [Tribolium castaneum] 768423227 XM_011554208.1 242 8.04371e-121 PREDICTED: Plutella xylostella histone-lysine N-methyltransferase SETD1-like (LOC105384048), mRNA K11422 SETD1, SET1 histone-lysine N-methyltransferase SETD1 http://www.genome.jp/dbget-bin/www_bget?ko:K11422 Q5LJZ2 1105 1.2e-118 Histone-lysine N-methyltransferase SETD1 OS=Drosophila melanogaster GN=Set1 PE=1 SV=1 PF00856//PF00076//PF03490 SET domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0003676//GO:0005515//GO:0047396 nucleic acid binding//protein binding//glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.33315 BP_3 419.13 24.13 1129 91089683 XP_974633.1 613 6.1e-61 PREDICTED: survival of motor neuron-related-splicing factor 30 [Tribolium castaneum]>gi|270011328|gb|EFA07776.1| hypothetical protein TcasGA2_TC005331 [Tribolium castaneum] -- -- -- -- -- K12839 SMNDC1, SPF30 survival of motor neuron-related-splicing factor 30 http://www.genome.jp/dbget-bin/www_bget?ko:K12839 Q7ZV80 181 3.1e-12 Survival of motor neuron-related-splicing factor 30 OS=Danio rerio GN=smndc1 PE=2 SV=1 PF06003 Survival motor neuron protein (SMN) GO:0006397 mRNA processing GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG3026 Splicing factor SPF30 Cluster-8309.33317 BP_3 1472.87 29.39 2707 478258665 ENN78715.1 1719 8.2e-189 hypothetical protein YQE_04887, partial [Dendroctonus ponderosae]>gi|546674937|gb|ERL86214.1| hypothetical protein D910_03625 [Dendroctonus ponderosae] -- -- -- -- -- K09527 DNAJC7 DnaJ homolog subfamily C member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09527 Q99615 1161 1.7e-125 DnaJ homolog subfamily C member 7 OS=Homo sapiens GN=DNAJC7 PE=1 SV=2 PF04196//PF13181//PF13174//PF13371//PF00515//PF13374//PF13414//PF13176 Bunyavirus RNA dependent RNA polymerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006351//GO:0019079//GO:0006144 transcription, DNA-templated//viral genome replication//purine nucleobase metabolic process GO:0003968//GO:0005515 RNA-directed RNA polymerase activity//protein binding GO:0031379 RNA-directed RNA polymerase complex KOG0550 Molecular chaperone (DnaJ superfamily) Cluster-8309.33319 BP_3 1322.37 30.29 2396 189238404 XP_001812043.1 1142 5.9e-122 PREDICTED: uncharacterized protein LOC100142307 [Tribolium castaneum]>gi|270009293|gb|EFA05741.1| hypothetical protein TcasGA2_TC015640 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3EWZ6 361 8.8e-33 MAM and LDL-receptor class A domain-containing protein 2 (Fragment) OS=Acropora millepora PE=1 SV=1 PF01033//PF00629 Somatomedin B domain//MAM domain, meprin/A5/mu GO:0006955//GO:0007165 immune response//signal transduction GO:0030247//GO:0005044 polysaccharide binding//scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.33320 BP_3 179.52 2.53 3710 642916768 XP_008192537.1 418 8.2e-38 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V3B7 326 1.6e-28 Peptidoglycan-recognition protein SC1a/b OS=Drosophila melanogaster GN=PGRP-SC1a PE=1 SV=1 PF01480//PF01510 PWI domain//N-acetylmuramoyl-L-alanine amidase GO:0006397//GO:0009253//GO:0006807//GO:0009252 mRNA processing//peptidoglycan catabolic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.33321 BP_3 215.76 2.66 4197 270009832 EFA06280.1 3210 0.0e+00 hypothetical protein TcasGA2_TC009146 [Tribolium castaneum] 686484113 KM036513.1 210 3.4827e-103 Locusta migratoria Mcm5 mRNA, complete cds K02209 MCM5, CDC46 DNA replication licensing factor MCM5 http://www.genome.jp/dbget-bin/www_bget?ko:K02209 Q9VGW6 2924 0.0e+00 DNA replication licensing factor Mcm5 OS=Drosophila melanogaster GN=Mcm5 PE=1 SV=1 PF00493//PF07728//PF07726//PF00158 MCM2/3/5 family//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003677//GO:0016887//GO:0005524//GO:0008134 DNA binding//ATPase activity//ATP binding//transcription factor binding GO:0005667 transcription factor complex KOG0481 DNA replication licensing factor, MCM5 component Cluster-8309.33322 BP_3 138.19 4.03 1946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33323 BP_3 638.00 115.89 557 -- -- -- -- -- 642939072 XM_008201989.1 71 8.15017e-27 PREDICTED: Tribolium castaneum DEAD-box ATP-dependent RNA helicase 20-like (LOC103312134), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33324 BP_3 648.34 4.98 6571 642939071 XP_008200210.1 2224 5.5e-247 PREDICTED: DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [Tribolium castaneum] 158300605 XM_320481.4 215 9.08398e-106 Anopheles gambiae str. PEST AGAP012045-PA (AgaP_AGAP012045) mRNA, complete cds K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1374 8.3e-150 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF00270//PF00816//PF03328//PF04851 DEAD/DEAH box helicase//H-NS histone family//HpcH/HpaI aldolase/citrate lyase family//Type III restriction enzyme, res subunit GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0003824//GO:0003676//GO:0003677//GO:0016787 ATP binding//catalytic activity//nucleic acid binding//DNA binding//hydrolase activity GO:0005622 intracellular KOG0331 ATP-dependent RNA helicase Cluster-8309.33325 BP_3 1760.72 17.18 5231 270016924 EFA13370.1 2629 4.8e-294 hypothetical protein TcasGA2_TC001907 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMW5 1504 5.6e-165 Rho GTPase-activating protein 26 OS=Gallus gallus GN=ARHGAP26 PE=1 SV=2 PF03114//PF01297//PF00018//PF14604//PF00620//PF01956//PF03155 BAR domain//Zinc-uptake complex component A periplasmic//SH3 domain//Variant SH3 domain//RhoGAP domain//Integral membrane protein DUF106//ALG6, ALG8 glycosyltransferase family GO:0030001//GO:0007165 metal ion transport//signal transduction GO:0016758//GO:0005515//GO:0046872 transferase activity, transferring hexosyl groups//protein binding//metal ion binding GO:0005789//GO:0016020//GO:0005737 endoplasmic reticulum membrane//membrane//cytoplasm KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins Cluster-8309.33327 BP_3 152.34 6.88 1359 91076690 XP_971724.1 912 1.6e-95 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 110 4.30959e-48 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 B2GV71 595 3.7e-60 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Rattus norvegicus GN=Ndufaf5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2940 Predicted methyltransferase Cluster-8309.33328 BP_3 632.30 19.48 1856 91076690 XP_971724.1 1361 1.8e-147 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 126 7.55974e-57 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 A2APY7 818 7.0e-86 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Mus musculus GN=Ndufaf5 PE=2 SV=1 PF01209//PF03492//PF05175//PF08241 ubiE/COQ5 methyltransferase family//SAM dependent carboxyl methyltransferase//Methyltransferase small domain//Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG2940 Predicted methyltransferase Cluster-8309.33329 BP_3 714.00 6.00 6023 91093752 XP_969444.1 1063 2.1e-112 PREDICTED: glyoxalase domain-containing protein 4 [Tribolium castaneum]>gi|270013016|gb|EFA09464.1| hypothetical protein TcasGA2_TC010680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5I0D1 786 1.2e-81 Glyoxalase domain-containing protein 4 OS=Rattus norvegicus GN=Glod4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2943 Predicted glyoxalase Cluster-8309.3333 BP_3 4.00 0.53 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09732 Cactus-binding C-terminus of cactin protein -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33330 BP_3 16.00 0.78 1282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33334 BP_3 790.00 42.44 1189 -- -- -- -- -- 642938152 XM_964275.2 92 3.80977e-38 PREDICTED: Tribolium castaneum neurocalcin homolog (LOC657840), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33335 BP_3 41.31 0.95 2385 91093203 XP_969368.1 329 1.1e-27 PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|642938151|ref|XP_008199786.1| PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|270016483|gb|EFA12929.1| hypothetical protein TcasGA2_TC010475 [Tribolium castaneum] 170043832 XM_001849523.1 124 1.262e-55 Culex quinquefasciatus hippocalcin, mRNA -- -- -- -- P42325 321 3.8e-28 Neurocalcin homolog OS=Drosophila melanogaster GN=Nca PE=1 SV=2 PF13405//PF13833//PF00036//PF13499//PF13202 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.33338 BP_3 20.25 1.13 1153 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33339 BP_3 642.87 4.16 7746 642918353 XP_008199964.1 4772 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 F1PBJ0 2374 1.1e-265 Rap guanine nucleotide exchange factor 2 OS=Canis familiaris GN=RAPGEF2 PE=1 SV=2 PF00788//PF13180//PF00617//PF00595 Ras association (RalGDS/AF-6) domain//PDZ domain//RasGEF domain//PDZ domain (Also known as DHR or GLGF) GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.33340 BP_3 42.33 1.68 1508 642918353 XP_008199964.1 209 5.7e-14 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33342 BP_3 44.95 0.94 2608 546678936 ERL89474.1 1255 5.1e-135 hypothetical protein D910_06840 [Dendroctonus ponderosae] 462304202 APGK01049574.1 91 3.05513e-37 Dendroctonus ponderosae Seq01049584, whole genome shotgun sequence K14206 SLC15A1, PEPT1 solute carrier family 15 (oligopeptide transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14206 P91679 673 6.4e-69 Peptide transporter family 1 OS=Drosophila melanogaster GN=yin PE=1 SV=2 PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1237 H+/oligopeptide symporter Cluster-8309.33344 BP_3 254.02 3.18 4143 642924817 XP_008194053.1 3651 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X5 [Tribolium castaneum] 749755570 XM_011141969.1 132 7.87415e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.2e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.33348 BP_3 37.16 0.47 4099 642921429 XP_974248.2 660 7.8e-66 PREDICTED: uncharacterized protein LOC663094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5VYS8 154 1.5e-08 Terminal uridylyltransferase 7 OS=Homo sapiens GN=ZCCHC6 PE=1 SV=1 PF09128//PF08039//PF09249 Regulator of G protein signalling-like domain//Mitochondrial proteolipid//tRNA nucleotidyltransferase, second domain GO:0043087//GO:0008033 regulation of GTPase activity//tRNA processing GO:0004810//GO:0016437//GO:0005089 tRNA adenylyltransferase activity//tRNA cytidylyltransferase activity//Rho guanyl-nucleotide exchange factor activity GO:0005739//GO:0005737 mitochondrion//cytoplasm KOG2277 S-M checkpoint control protein CID1 and related nucleotidyltransferases Cluster-8309.33350 BP_3 184.86 5.99 1779 270014882 EFA11330.1 1355 8.7e-147 hypothetical protein TcasGA2_TC010869 [Tribolium castaneum] -- -- -- -- -- K01349 FURIN, PCSK3 furin http://www.genome.jp/dbget-bin/www_bget?ko:K01349 P26016 1028 3.0e-110 Furin-like protease 1, isoforms 1/1-X/2 OS=Drosophila melanogaster GN=Fur1 PE=2 SV=2 PF01483//PF00082 Proprotein convertase P-domain//Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3525 Subtilisin-like proprotein convertase Cluster-8309.33351 BP_3 34.69 11.47 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33352 BP_3 3517.92 108.12 1860 332374558 AEE62420.1 2409 5.5e-269 unknown [Dendroctonus ponderosae] 871221006 XM_013080402.1 252 6.86192e-127 PREDICTED: Aplysia californica T-complex protein 1 subunit alpha-like (LOC101853150), mRNA K09493 CCT1, TCP1 T-complex protein 1 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K09493 P12613 2275 7.8e-255 T-complex protein 1 subunit alpha OS=Drosophila melanogaster GN=T-cp1 PE=2 SV=2 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0360 Chaperonin complex component, TCP-1 alpha subunit (CCT1) Cluster-8309.33355 BP_3 939.77 38.61 1465 91076380 XP_968185.1 1749 1.5e-192 PREDICTED: interleukin enhancer-binding factor 2 homolog [Tribolium castaneum]>gi|270002554|gb|EEZ99001.1| hypothetical protein TcasGA2_TC004865 [Tribolium castaneum] 332373637 BT126998.1 276 2.44902e-140 Dendroctonus ponderosae clone DPO1124_K05 unknown mRNA K13089 ILF2 interleukin enhancer-binding factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13089 Q9VG73 1299 9.2e-142 Interleukin enhancer-binding factor 2 homolog OS=Drosophila melanogaster GN=CG5641 PE=2 SV=1 -- -- GO:0006955 immune response GO:0016740//GO:0003723//GO:0005524 transferase activity//RNA binding//ATP binding -- -- KOG3793 Transcription factor NFAT, subunit NF45 Cluster-8309.33356 BP_3 191.66 6.00 1832 91090252 XP_969934.1 425 6.2e-39 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 Q9CPQ3 236 2.1e-18 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=2 SV=3 PF04281 Mitochondrial import receptor subunit Tom22 GO:0006886 intracellular protein transport -- -- GO:0005741 mitochondrial outer membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.33360 BP_3 495.04 8.19 3206 642911078 XP_008200566.1 2414 2.5e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 2.9e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF13442//PF00641//PF01585//PF07808//PF11648//PF00076 Cytochrome C oxidase, cbb3-type, subunit III//Zn-finger in Ran binding protein and others//G-patch domain//RED-like protein N-terminal region//C-terminal domain of RIG-I//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006118 obsolete electron transport GO:0003676//GO:0000166//GO:0008270//GO:0009055//GO:0016817//GO:0020037 nucleic acid binding//nucleotide binding//zinc ion binding//electron carrier activity//hydrolase activity, acting on acid anhydrides//heme binding GO:0005634//GO:0005622 nucleus//intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.33361 BP_3 45.13 1.00 2476 91090986 XP_974863.1 1688 3.0e-185 PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936123|ref|XP_008198309.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936125|ref|XP_008198310.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|270013188|gb|EFA09636.1| hypothetical protein TcasGA2_TC011759 [Tribolium castaneum] 642936121 XM_969770.3 61 1.37742e-20 PREDICTED: Tribolium castaneum ubiquitin thioesterase trabid (LOC663735), transcript variant X1, mRNA K11862 ZRANB1, TRABID ubiquitin thioesterase ZRANB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11862 Q9VH90 1055 3.1e-113 Ubiquitin thioesterase trabid OS=Drosophila melanogaster GN=trbd PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG4345 NF-kappa B regulator AP20/Cezanne Cluster-8309.33362 BP_3 161.00 11.03 995 801370811 XP_012060089.1 150 2.6e-07 PREDICTED: uncharacterized protein LOC105623298 [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33364 BP_3 461.62 6.50 3716 270010575 EFA07023.1 1789 8.6e-197 hypothetical protein TcasGA2_TC009994 [Tribolium castaneum] -- -- -- -- -- K11324 DMAP1, SWC4, EAF2 DNA methyltransferase 1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11324 Q9JI44 1182 8.6e-128 DNA methyltransferase 1-associated protein 1 OS=Mus musculus GN=Dmap1 PE=1 SV=1 PF05499 DNA methyltransferase 1-associated protein 1 (DMAP1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2656 DNA methyltransferase 1-associated protein-1 Cluster-8309.33365 BP_3 61.44 0.82 3897 478257309 ENN77469.1 1230 6.0e-132 hypothetical protein YQE_05997, partial [Dendroctonus ponderosae] -- -- -- -- -- K11324 DMAP1, SWC4, EAF2 DNA methyltransferase 1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11324 Q9NPF5 849 3.7e-89 DNA methyltransferase 1-associated protein 1 OS=Homo sapiens GN=DMAP1 PE=1 SV=1 PF05499 DNA methyltransferase 1-associated protein 1 (DMAP1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2656 DNA methyltransferase 1-associated protein-1 Cluster-8309.33366 BP_3 21.82 0.80 1608 332374052 AEE62167.1 738 2.8e-75 unknown [Dendroctonus ponderosae]>gi|478263264|gb|ENN81648.1| hypothetical protein YQE_01946, partial [Dendroctonus ponderosae]>gi|546673295|gb|ERL84927.1| hypothetical protein D910_02350 [Dendroctonus ponderosae] 831570078 XM_012879141.1 114 3.05977e-50 PREDICTED: Fundulus heteroclitus ubiquitin-conjugating enzyme E2E 1 (ube2e1), transcript variant X2, mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P52485 668 1.5e-68 Ubiquitin-conjugating enzyme E2-24 kDa OS=Drosophila melanogaster GN=UbcD2 PE=2 SV=1 PF05773//PF02060 RWD domain//Slow voltage-gated potassium channel GO:0006811//GO:0006813 ion transport//potassium ion transport GO:0005515//GO:0005249 protein binding//voltage-gated potassium channel activity GO:0008076//GO:0016020 voltage-gated potassium channel complex//membrane KOG0417 Ubiquitin-protein ligase Cluster-8309.33367 BP_3 4359.59 152.90 1666 332374052 AEE62167.1 903 2.1e-94 unknown [Dendroctonus ponderosae]>gi|478263264|gb|ENN81648.1| hypothetical protein YQE_01946, partial [Dendroctonus ponderosae]>gi|546673295|gb|ERL84927.1| hypothetical protein D910_02350 [Dendroctonus ponderosae] 551506028 XM_005804490.1 134 2.41811e-61 PREDICTED: Xiphophorus maculatus ubiquitin-conjugating enzyme E2 E2-like (LOC102229941), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P52485 836 5.1e-88 Ubiquitin-conjugating enzyme E2-24 kDa OS=Drosophila melanogaster GN=UbcD2 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.33368 BP_3 25.30 0.43 3098 332374052 AEE62167.1 738 5.3e-75 unknown [Dendroctonus ponderosae]>gi|478263264|gb|ENN81648.1| hypothetical protein YQE_01946, partial [Dendroctonus ponderosae]>gi|546673295|gb|ERL84927.1| hypothetical protein D910_02350 [Dendroctonus ponderosae] 831570078 XM_012879141.1 114 5.95428e-50 PREDICTED: Fundulus heteroclitus ubiquitin-conjugating enzyme E2E 1 (ube2e1), transcript variant X2, mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P52485 668 2.9e-68 Ubiquitin-conjugating enzyme E2-24 kDa OS=Drosophila melanogaster GN=UbcD2 PE=2 SV=1 PF02060//PF05773 Slow voltage-gated potassium channel//RWD domain GO:0006813//GO:0006811 potassium ion transport//ion transport GO:0005249//GO:0005515 voltage-gated potassium channel activity//protein binding GO:0008076//GO:0016020 voltage-gated potassium channel complex//membrane KOG0417 Ubiquitin-protein ligase Cluster-8309.33370 BP_3 138.00 5.50 1501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33371 BP_3 12.87 0.35 2079 91094295 XP_971662.1 1530 5.2e-167 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 P81140 1353 7.2e-148 Glutaryl-CoA dehydrogenase, mitochondrial (Fragment) OS=Sus scrofa GN=GCDH PE=1 SV=1 PF00441//PF07180//PF02771//PF02770 Acyl-CoA dehydrogenase, C-terminal domain//Protein of unknown function (DUF1401)//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0006118//GO:0006351//GO:0008152//GO:0055114 obsolete electron transport//transcription, DNA-templated//metabolic process//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.33372 BP_3 166.96 6.11 1609 91094295 XP_971662.1 1667 5.2e-183 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 1449 4.1e-159 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.33374 BP_3 1.00 24.86 221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33378 BP_3 261.60 1.15 11294 642936312 XP_008198391.1 8183 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 9.75812e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3630 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF14604//PF00018//PF01608//PF07651//PF03822 Variant SH3 domain//SH3 domain//I/LWEQ domain//ANTH domain//NAF domain GO:0007165 signal transduction GO:0003779//GO:0005515//GO:0005543 actin binding//protein binding//phospholipid binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.33379 BP_3 851.70 4.28 9873 642936312 XP_008198391.1 6193 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 8.52633e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 2619 5.4e-294 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF07651//PF01608//PF03822 ANTH domain//I/LWEQ domain//NAF domain GO:0007165 signal transduction GO:0005543//GO:0003779 phospholipid binding//actin binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.33380 BP_3 280.19 4.43 3343 642916840 XP_008199525.1 1090 8.8e-116 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X3 [Tribolium castaneum] 170068311 XM_001868784.1 204 5.99147e-100 Culex quinquefasciatus serine/threonine-protein phosphatase 2B catalytic subunit 2, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 933 5.8e-99 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.33381 BP_3 65.77 1.58 2303 642916834 XP_008199522.1 590 5.8e-58 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum]>gi|642916836|ref|XP_008199523.1| PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum] 642916835 XM_008201301.1 191 6.9269e-93 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2B catalytic subunit 2-like (LOC657135), transcript variant X2, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 460 2.8e-44 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.33382 BP_3 325.32 4.54 3742 642916840 XP_008199525.1 456 3.2e-42 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X3 [Tribolium castaneum] 170068311 XM_001868784.1 137 1.18059e-62 Culex quinquefasciatus serine/threonine-protein phosphatase 2B catalytic subunit 2, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 P48454 401 3.2e-37 Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform OS=Homo sapiens GN=PPP3CC PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.33383 BP_3 49.07 1.59 1780 642923490 XP_008193532.1 1769 8.6e-195 PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum]>gi|642923492|ref|XP_967512.2| PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum] 198474593 XM_002132688.1 75 1.62456e-28 Drosophila pseudoobscura pseudoobscura GA25723 (Dpse\GA25723), partial mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 1234 3.9e-134 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008417 fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.33384 BP_3 67.66 0.61 5622 642924099 XP_008194004.1 1477 2.0e-160 PREDICTED: division abnormally delayed protein [Tribolium castaneum] 642924098 XM_008195782.1 56 1.89647e-17 PREDICTED: Tribolium castaneum division abnormally delayed protein (LOC656854), mRNA K02306 DALLY dally http://www.genome.jp/dbget-bin/www_bget?ko:K02306 Q24114 730 3.4e-75 Division abnormally delayed protein OS=Drosophila melanogaster GN=dally PE=1 SV=1 PF07657//PF01153//PF01392 N terminus of Notch ligand//Glypican//Fz domain GO:0007275//GO:0007219 multicellular organismal development//Notch signaling pathway GO:0043395//GO:0005515 heparan sulfate proteoglycan binding//protein binding GO:0005578//GO:0016020//GO:0016021 proteinaceous extracellular matrix//membrane//integral component of membrane -- -- Cluster-8309.33385 BP_3 2064.83 18.68 5620 642924099 XP_008194004.1 1477 2.0e-160 PREDICTED: division abnormally delayed protein [Tribolium castaneum] 642924098 XM_008195782.1 56 1.8958e-17 PREDICTED: Tribolium castaneum division abnormally delayed protein (LOC656854), mRNA K02306 DALLY dally http://www.genome.jp/dbget-bin/www_bget?ko:K02306 Q24114 730 3.4e-75 Division abnormally delayed protein OS=Drosophila melanogaster GN=dally PE=1 SV=1 PF07657//PF01392//PF01153 N terminus of Notch ligand//Fz domain//Glypican GO:0007219//GO:0007275 Notch signaling pathway//multicellular organismal development GO:0005515//GO:0043395 protein binding//heparan sulfate proteoglycan binding GO:0016021//GO:0005578//GO:0016020 integral component of membrane//proteinaceous extracellular matrix//membrane -- -- Cluster-8309.33387 BP_3 319.00 5.58 3045 642922001 XP_008192976.1 1182 1.7e-126 PREDICTED: homeobox protein SIX2 [Tribolium castaneum] 699693291 XM_009891221.1 243 1.13905e-121 PREDICTED: Charadrius vociferus SIX homeobox 1 (SIX1), partial mRNA K15614 SIX1 homeobox protein SIX1 http://www.genome.jp/dbget-bin/www_bget?ko:K15614 Q27350 935 3.1e-99 Protein sine oculis OS=Drosophila melanogaster GN=so PE=2 SV=1 PF05920//PF02159//PF01381//PF00046//PF03964 Homeobox KN domain//Oestrogen receptor//Helix-turn-helix//Homeobox domain//Chorion family 2 GO:0007165//GO:0007275//GO:0006355//GO:0043401 signal transduction//multicellular organismal development//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003677//GO:0005496//GO:0030284//GO:0043565 DNA binding//steroid binding//estrogen receptor activity//sequence-specific DNA binding GO:0005634//GO:0042600 nucleus//chorion KOG0775 Transcription factor SIX and related HOX domain proteins Cluster-8309.33389 BP_3 77.26 2.56 1745 478263077 ENN81477.1 469 4.7e-44 hypothetical protein YQE_02169, partial [Dendroctonus ponderosae]>gi|546682119|gb|ERL92100.1| hypothetical protein D910_09421 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33391 BP_3 79.46 1.41 3001 91087321 XP_975587.1 665 1.5e-66 PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|642929809|ref|XP_008195985.1| PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|270009526|gb|EFA05974.1| hypothetical protein TcasGA2_TC008799 [Tribolium castaneum] 186969251 EU616728.1 55 3.62049e-17 Kryptolebias marmoratus R-ras3 mRNA, complete cds K07830 RRAS2, TC21 Ras-related protein R-Ras2 http://www.genome.jp/dbget-bin/www_bget?ko:K07830 P04388 507 1.3e-49 Ras-like protein 2 OS=Drosophila melanogaster GN=Ras64B PE=1 SV=2 PF08477//PF08469//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Nucleoside triphosphatase I C-terminal//ADP-ribosylation factor family//Ras family GO:0006351//GO:0007264//GO:0006184 transcription, DNA-templated//small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005524//GO:0017111//GO:0005525 GTPase activity//ATP binding//nucleoside-triphosphatase activity//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.33392 BP_3 47.88 16.97 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33393 BP_3 314.31 4.33 3791 642924780 XP_975331.2 997 6.1e-105 PREDICTED: protein FAM122A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZLN7 147 9.1e-08 Protein FAM122A OS=Gallus gallus GN=FAM122A PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33397 BP_3 827.39 35.95 1401 642937984 XP_008199157.1 229 2.5e-16 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33398 BP_3 27.00 0.91 1726 642930472 XP_008196416.1 937 2.5e-98 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 777 3.7e-81 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.334 BP_3 2.15 0.65 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33402 BP_3 1131.00 5.26 10649 642911064 XP_008200559.1 6648 0.0e+00 PREDICTED: nipped-B-like protein isoform X1 [Tribolium castaneum]>gi|270014671|gb|EFA11119.1| hypothetical protein TcasGA2_TC004719 [Tribolium castaneum] 766925181 XM_011496172.1 131 7.31538e-59 PREDICTED: Ceratosolen solmsi marchali nipped-B-like protein A (LOC105359557), mRNA K06672 SCC2, NIPBL cohesin loading factor subunit SCC2 http://www.genome.jp/dbget-bin/www_bget?ko:K06672 Q6KC79 3335 0.0e+00 Nipped-B-like protein OS=Homo sapiens GN=NIPBL PE=1 SV=2 PF02985//PF05875//PF02532 HEAT repeat//Ceramidase//Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979//GO:0006672//GO:0006807 photosynthesis//ceramide metabolic process//nitrogen compound metabolic process GO:0016811//GO:0005515 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//protein binding GO:0016021//GO:0016020//GO:0009523//GO:0009539 integral component of membrane//membrane//photosystem II//photosystem II reaction center KOG1020 Sister chromatid cohesion protein SCC2/Nipped-B Cluster-8309.33407 BP_3 250.00 9.15 1609 642912027 XP_008199065.1 1139 8.8e-122 PREDICTED: aldose 1-epimerase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K01785 galM, GALM aldose 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01785 Q5EA79 798 1.3e-83 Aldose 1-epimerase OS=Bos taurus GN=GALM PE=2 SV=1 PF01263 Aldose 1-epimerase GO:0005975 carbohydrate metabolic process GO:0016853 isomerase activity -- -- KOG1604 Predicted mutarotase Cluster-8309.33410 BP_3 1051.56 27.41 2141 91085815 XP_974770.1 1408 7.5e-153 PREDICTED: maternal protein exuperantia-1 [Tribolium castaneum]>gi|270011046|gb|EFA07494.1| exuperantia [Tribolium castaneum] -- -- -- -- -- K18745 EXU maternal protein exuperantia http://www.genome.jp/dbget-bin/www_bget?ko:K18745 Q24747 596 4.4e-60 Maternal protein exuperantia OS=Drosophila virilis GN=exu PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33411 BP_3 68.92 0.43 8071 91094409 XP_967943.1 1273 1.3e-136 PREDICTED: acyl-CoA Delta(11) desaturase [Tribolium castaneum]>gi|270016351|gb|EFA12797.1| hypothetical protein TcasGA2_TC014819 [Tribolium castaneum]>gi|576636744|gb|AHH30814.1| fatty acid desaturase D7 [Tribolium castaneum] 817052910 XM_012403667.1 98 1.22453e-40 PREDICTED: Athalia rosae acyl-CoA Delta(11) desaturase (LOC105687776), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 780 7.7e-81 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 PF04863//PF00323//PF00487 Alliinase EGF-like domain//Mammalian defensin//Fatty acid desaturase GO:0055114//GO:0006633//GO:0006952//GO:0006629 oxidation-reduction process//fatty acid biosynthetic process//defense response//lipid metabolic process GO:0016846//GO:0016717 carbon-sulfur lyase activity//oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.33415 BP_3 151.45 1.60 4862 91092640 XP_969145.1 2951 0.0e+00 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1246 4.3e-135 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 PF00628 PHD-finger -- -- GO:0043169//GO:0005515 cation binding//protein binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.33416 BP_3 38.08 0.38 5065 189236304 XP_975050.2 846 2.6e-87 PREDICTED: alkaline phosphatase 4 [Tribolium castaneum]>gi|270005478|gb|EFA01926.1| hypothetical protein TcasGA2_TC007539 [Tribolium castaneum] 642919537 XM_969957.3 79 2.79704e-30 PREDICTED: Tribolium castaneum alkaline phosphatase 4 (LOC663929), mRNA K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 Q24238 564 5.4e-56 Alkaline phosphatase 4 OS=Drosophila melanogaster GN=Aph-4 PE=2 SV=3 PF01676//PF00245 Metalloenzyme superfamily//Alkaline phosphatase GO:0008152 metabolic process GO:0016787//GO:0003824//GO:0046872//GO:0016791 hydrolase activity//catalytic activity//metal ion binding//phosphatase activity -- -- -- -- Cluster-8309.33417 BP_3 132.27 1.63 4214 170032167 XP_001843954.1 913 3.7e-95 conserved hypothetical protein [Culex quinquefasciatus]>gi|167871903|gb|EDS35286.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P30839 745 4.6e-77 Fatty aldehyde dehydrogenase OS=Rattus norvegicus GN=Aldh3a2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0006570//GO:0006081//GO:0008152//GO:0006096//GO:0055114//GO:0006547//GO:0006094//GO:0006558 tyrosine metabolic process//cellular aldehyde metabolic process//metabolic process//glycolytic process//oxidation-reduction process//histidine metabolic process//gluconeogenesis//L-phenylalanine metabolic process GO:0016491//GO:0004030 oxidoreductase activity//aldehyde dehydrogenase [NAD(P)+] activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.33418 BP_3 11.88 0.32 2091 642930433 XP_008196400.1 386 2.4e-34 PREDICTED: death-associated protein 1 [Tribolium castaneum]>gi|270010727|gb|EFA07175.1| hypothetical protein TcasGA2_TC010175 [Tribolium castaneum] -- -- -- -- -- K03104 SRP14 signal recognition particle subunit SRP14 http://www.genome.jp/dbget-bin/www_bget?ko:K03104 A6QQL9 236 2.4e-18 Signal recognition particle 14 kDa protein OS=Bos taurus GN=SRP14 PE=3 SV=1 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0030942 7S RNA binding//endoplasmic reticulum signal peptide binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG1761 Signal recognition particle, subunit Srp14 Cluster-8309.33419 BP_3 2506.12 91.42 1613 642930433 XP_008196400.1 445 2.6e-41 PREDICTED: death-associated protein 1 [Tribolium castaneum]>gi|270010727|gb|EFA07175.1| hypothetical protein TcasGA2_TC010175 [Tribolium castaneum] -- -- -- -- -- K03104 SRP14 signal recognition particle subunit SRP14 http://www.genome.jp/dbget-bin/www_bget?ko:K03104 A6QQL9 236 1.9e-18 Signal recognition particle 14 kDa protein OS=Bos taurus GN=SRP14 PE=3 SV=1 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0030942//GO:0008312 endoplasmic reticulum signal peptide binding//7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG1761 Signal recognition particle, subunit Srp14 Cluster-8309.33422 BP_3 50.00 0.82 3241 478253163 ENN73534.1 191 1.5e-11 hypothetical protein YQE_09785, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF13912//PF16622//PF13465//PF02701//PF07503//PF03811//PF00096//PF02176//PF05495 BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Dof domain, zinc finger//HypF finger//InsA N-terminal domain//Zinc finger, C2H2 type//TRAF-type zinc finger//CHY zinc finger GO:0006355//GO:0006313 regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.33425 BP_3 817.52 11.22 3805 270010190 EFA06638.1 2387 4.0e-266 hypothetical protein TcasGA2_TC009560, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UH06 502 6.3e-49 Ras-responsive element-binding protein 1 OS=Mus musculus GN=Rreb1 PE=1 SV=2 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.33426 BP_3 9.31 0.34 1628 189239344 XP_973859.2 1418 4.0e-154 PREDICTED: 28S ribosomal protein S5, mitochondrial [Tribolium castaneum]>gi|270010452|gb|EFA06900.1| hypothetical protein TcasGA2_TC009847 [Tribolium castaneum] -- -- -- -- -- K02988 RP-S5, MRPS5, rpsE small subunit ribosomal protein S5 http://www.genome.jp/dbget-bin/www_bget?ko:K02988 Q2KID9 566 1.0e-56 28S ribosomal protein S5, mitochondrial OS=Bos taurus GN=MRPS5 PE=1 SV=1 PF00333//PF03719 Ribosomal protein S5, N-terminal domain//Ribosomal protein S5, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840 ribosome KOG2646 Ribosomal protein S5 Cluster-8309.33428 BP_3 163.00 4.11 2205 642912957 XP_008201325.1 377 2.8e-33 PREDICTED: leucine-rich repeat-containing protein let-4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TJ59 205 1.0e-14 Toll-like receptor 3 OS=Bos taurus GN=TLR3 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33429 BP_3 178.26 2.54 3672 91079026 XP_974912.1 1817 4.8e-200 PREDICTED: rap1 GTPase-GDP dissociation stimulator 1-B [Tribolium castaneum]>gi|270003670|gb|EFA00118.1| hypothetical protein TcasGA2_TC002934 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52306 590 3.8e-59 Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens GN=RAP1GDS1 PE=1 SV=3 PF11698//PF00514 V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.33430 BP_3 13.86 0.35 2225 642925464 XP_008194565.1 397 1.3e-35 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.33433 BP_3 75.44 1.84 2266 478252289 ENN72716.1 268 1.2e-20 hypothetical protein YQE_10654, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7M4F1 184 2.8e-12 Endocuticle structural glycoprotein SgAbd-4 OS=Schistocerca gregaria PE=1 SV=1 PF13184 NusA-like KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.33434 BP_3 2742.00 85.92 1830 91078026 XP_970646.1 2311 1.3e-257 PREDICTED: T-complex protein 1 subunit beta [Tribolium castaneum]>gi|270001410|gb|EEZ97857.1| hypothetical protein TcasGA2_TC000229 [Tribolium castaneum] 167526083 XM_001747324.1 111 1.62448e-48 Monosiga brevicollis MX1 predicted protein MONBRDRAFT_33089 mRNA, complete cds K09494 CCT2 T-complex protein 1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K09494 Q3ZBH0 1941 4.1e-216 T-complex protein 1 subunit beta OS=Bos taurus GN=CCT2 PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding GO:0005737 cytoplasm KOG0363 Chaperonin complex component, TCP-1 beta subunit (CCT2) Cluster-8309.33436 BP_3 2.00 1.11 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33437 BP_3 525.00 13.98 2102 91094301 XP_971831.1 650 5.8e-65 PREDICTED: uncharacterized protein LOC660513 [Tribolium castaneum]>gi|270014382|gb|EFA10830.1| hypothetical protein TcasGA2_TC001606 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33438 BP_3 66012.00 2052.37 1842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33440 BP_3 494.10 33.53 1002 332372870 AEE61577.1 250 6.7e-19 unknown [Dendroctonus ponderosae]>gi|478256263|gb|ENN76453.1| hypothetical protein YQE_06907, partial [Dendroctonus ponderosae]>gi|546679245|gb|ERL89739.1| hypothetical protein D910_07100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D1L0 168 8.8e-11 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Mus musculus GN=Chchd2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4090 Uncharacterized conserved protein Cluster-8309.33441 BP_3 2131.56 63.49 1910 189239542 XP_001816493.1 505 3.4e-48 PREDICTED: uncharacterized protein LOC100141605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33443 BP_3 288.87 7.95 2043 642912011 XP_008199059.1 951 7.0e-100 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96PE2 530 1.9e-52 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.33444 BP_3 1108.71 19.62 3015 478262467 ENN81138.1 1903 4.2e-210 hypothetical protein YQE_02505, partial [Dendroctonus ponderosae] -- -- -- -- -- K14258 TRET1 facilitated trehalose transporter http://www.genome.jp/dbget-bin/www_bget?ko:K14258 Q17NV8 1407 5.7e-154 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF00083//PF07690//PF06849 Sugar (and other) transporter//Major Facilitator Superfamily//Protein of unknown function (DUF1246) GO:0006188//GO:0055085 IMP biosynthetic process//transmembrane transport GO:0000287//GO:0016879//GO:0022857//GO:0005524 magnesium ion binding//ligase activity, forming carbon-nitrogen bonds//transmembrane transporter activity//ATP binding GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33447 BP_3 104.14 1.43 3799 91079594 XP_967887.1 1746 8.6e-192 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X1 [Tribolium castaneum]>gi|270003396|gb|EEZ99843.1| hypothetical protein TcasGA2_TC002624 [Tribolium castaneum] 194884182 XM_001976139.1 162 1.51812e-76 Drosophila erecta GG22721 (Dere\GG22721), mRNA K11975 RNF144 E3 ubiquitin-protein ligase RNF144 http://www.genome.jp/dbget-bin/www_bget?ko:K11975 Q925F3 770 5.3e-80 E3 ubiquitin-protein ligase RNF144A OS=Mus musculus GN=Rnf144a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.33448 BP_3 329.43 4.56 3774 91079594 XP_967887.1 1746 8.5e-192 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X1 [Tribolium castaneum]>gi|270003396|gb|EEZ99843.1| hypothetical protein TcasGA2_TC002624 [Tribolium castaneum] 194884182 XM_001976139.1 162 1.50803e-76 Drosophila erecta GG22721 (Dere\GG22721), mRNA K11975 RNF144 E3 ubiquitin-protein ligase RNF144 http://www.genome.jp/dbget-bin/www_bget?ko:K11975 Q925F3 770 5.2e-80 E3 ubiquitin-protein ligase RNF144A OS=Mus musculus GN=Rnf144a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.33450 BP_3 108.68 1.63 3497 642917640 XP_008193443.1 1580 1.4e-172 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X2 [Tribolium castaneum] 194884182 XM_001976139.1 162 1.39628e-76 Drosophila erecta GG22721 (Dere\GG22721), mRNA K11975 RNF144 E3 ubiquitin-protein ligase RNF144 http://www.genome.jp/dbget-bin/www_bget?ko:K11975 Q925F3 770 4.8e-80 E3 ubiquitin-protein ligase RNF144A OS=Mus musculus GN=Rnf144a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.33451 BP_3 154.32 1.27 6155 478252889 ENN73274.1 3178 0.0e+00 hypothetical protein YQE_10104, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 6.6e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.33452 BP_3 265.27 5.18 2760 270004742 EFA01190.1 2041 3.9e-226 hypothetical protein TcasGA2_TC010516 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 1586 9.1e-175 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006525//GO:0006560//GO:0006814//GO:0071436//GO:0006090 arginine metabolic process//proline metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane KOG3097 Predicted membrane protein Cluster-8309.33453 BP_3 100.20 3.03 1887 478250970 ENN71454.1 862 1.4e-89 hypothetical protein YQE_11872, partial [Dendroctonus ponderosae]>gi|546682661|gb|ERL92573.1| hypothetical protein D910_09886 [Dendroctonus ponderosae] -- -- -- -- -- K15143 MED30 mediator of RNA polymerase II transcription subunit 30 http://www.genome.jp/dbget-bin/www_bget?ko:K15143 Q172Y1 530 1.8e-52 Mediator of RNA polymerase II transcription subunit 30 OS=Aedes aegypti GN=MED30 PE=3 SV=1 PF04546//PF03153 Sigma-70, non-essential region//Transcription factor IIA, alpha/beta subunit GO:0006355//GO:0006352//GO:0006367 regulation of transcription, DNA-templated//DNA-templated transcription, initiation//transcription initiation from RNA polymerase II promoter GO:0003677//GO:0016987//GO:0003700 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005672 transcription factor complex//transcription factor TFIIA complex -- -- Cluster-8309.33455 BP_3 76.44 2.60 1707 478250970 ENN71454.1 937 2.5e-98 hypothetical protein YQE_11872, partial [Dendroctonus ponderosae]>gi|546682661|gb|ERL92573.1| hypothetical protein D910_09886 [Dendroctonus ponderosae] -- -- -- -- -- K15143 MED30 mediator of RNA polymerase II transcription subunit 30 http://www.genome.jp/dbget-bin/www_bget?ko:K15143 Q172Y1 539 1.4e-53 Mediator of RNA polymerase II transcription subunit 30 OS=Aedes aegypti GN=MED30 PE=3 SV=1 PF03153//PF04546 Transcription factor IIA, alpha/beta subunit//Sigma-70, non-essential region GO:0006355//GO:0006367//GO:0006352 regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0003700 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005672 transcription factor complex//transcription factor TFIIA complex -- -- Cluster-8309.33456 BP_3 1055.00 16.69 3338 642927268 XP_008195200.1 1817 4.4e-200 PREDICTED: poly(A) RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270009992|gb|EFA06440.1| hypothetical protein TcasGA2_TC009322 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDN6 793 9.9e-83 Thioredoxin-like protein 1 OS=Mus musculus GN=Txnl1 PE=2 SV=3 PF01909//PF00085//PF00578 Nucleotidyltransferase domain//Thioredoxin//AhpC/TSA family GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0016491//GO:0016779 antioxidant activity//oxidoreductase activity//nucleotidyltransferase activity -- -- KOG0908 Thioredoxin-like protein Cluster-8309.33457 BP_3 2000.89 46.38 2371 91092940 XP_972197.1 1829 1.3e-201 PREDICTED: ubiquitin carboxyl-terminal hydrolase 10 [Tribolium castaneum]>gi|270004786|gb|EFA01234.1| ubiquitin-specific protease [Tribolium castaneum] 769845732 XM_011635837.1 42 4.80853e-10 PREDICTED: Pogonomyrmex barbatus ubiquitin carboxyl-terminal hydrolase 10 (LOC105425187), mRNA K11841 USP10, UBP3 ubiquitin carboxyl-terminal hydrolase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K11841 Q5ZJN4 889 5.2e-94 Ubiquitin carboxyl-terminal hydrolase 10 OS=Gallus gallus GN=USP10 PE=2 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0006511//GO:0016579 ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0036459//GO:0004221//GO:0008233 ubiquitinyl hydrolase activity//obsolete ubiquitin thiolesterase activity//peptidase activity -- -- KOG1871 Ubiquitin-specific protease Cluster-8309.33459 BP_3 209.01 9.01 1410 642922794 XP_008193328.1 1036 6.8e-110 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 572 1.8e-57 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.3346 BP_3 5.00 1.25 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33460 BP_3 19.40 0.58 1908 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33461 BP_3 112.05 1.15 4997 642911773 XP_008200735.1 1282 7.2e-138 PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911775|ref|XP_008200736.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911777|ref|XP_008200737.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911779|ref|XP_008200738.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|270014735|gb|EFA11183.1| hypothetical protein TcasGA2_TC004791 [Tribolium castaneum] 397560823 JX204291.1 39 4.74967e-08 Sogatella furcifera membrane-bound trehalase mRNA, complete cds K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 A8J4S9 1039 4.4e-111 Trehalase OS=Apis mellifera PE=1 SV=1 PF01204 Trehalase GO:0005991//GO:0005985//GO:0005982 trehalose metabolic process//sucrose metabolic process//starch metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.33463 BP_3 421.50 6.18 3579 91082533 XP_973629.1 1814 1.0e-199 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X1 [Tribolium castaneum]>gi|270007557|gb|EFA04005.1| hypothetical protein TcasGA2_TC014154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 879 1.1e-92 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.33464 BP_3 157.39 1.84 4423 478251314 ENN71782.1 3494 0.0e+00 hypothetical protein YQE_11516, partial [Dendroctonus ponderosae]>gi|546673516|gb|ERL85102.1| hypothetical protein D910_02524 [Dendroctonus ponderosae] -- -- -- -- -- K14569 BMS1 ribosome biogenesis protein BMS1 http://www.genome.jp/dbget-bin/www_bget?ko:K14569 Q14692 1364 8.1e-149 Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens GN=BMS1 PE=1 SV=1 PF08142 AARP2CN (NUC121) domain GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1951 GTP-binding protein AARP2 involved in 40S ribosome biogenesis Cluster-8309.33467 BP_3 13.00 0.57 1390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33468 BP_3 1251.00 32.05 2173 91093403 XP_966518.1 2192 9.4e-244 PREDICTED: inosine-5'-monophosphate dehydrogenase [Tribolium castaneum]>gi|270015409|gb|EFA11857.1| hypothetical protein TcasGA2_TC005099 [Tribolium castaneum] 389612629 AK403490.1 77 1.5387e-29 Papilio xuthus mRNA, raspberry, sequence id: Px-1664, expressed in epidermis K00088 guaB IMP dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00088 Q07152 1975 5.6e-220 Inosine-5'-monophosphate dehydrogenase OS=Drosophila melanogaster GN=ras PE=1 SV=1 PF00218//PF00977//PF01081//PF04309//PF03060//PF01070//PF00478//PF01645//PF04131//PF01180 Indole-3-glycerol phosphate synthase//Histidine biosynthesis protein//KDPG and KHG aldolase//Glycerol-3-phosphate responsive antiterminator//Nitronate monooxygenase//FMN-dependent dehydrogenase//IMP dehydrogenase / GMP reductase domain//Conserved region in glutamate synthase//Putative N-acetylmannosamine-6-phosphate epimerase//Dihydroorotate dehydrogenase GO:0006537//GO:0006571//GO:0055114//GO:0006355//GO:0009607//GO:0006177//GO:0006051//GO:0006144//GO:0008152//GO:0006040//GO:0006807//GO:0000105//GO:0000162//GO:0009094 glutamate biosynthetic process//tyrosine biosynthetic process//oxidation-reduction process//regulation of transcription, DNA-templated//response to biotic stimulus//GMP biosynthetic process//N-acetylmannosamine metabolic process//purine nucleobase metabolic process//metabolic process//amino sugar metabolic process//nitrogen compound metabolic process//histidine biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process GO:0018580//GO:0004425//GO:0047465//GO:0016627//GO:0016638//GO:0003938//GO:0016829//GO:0000166//GO:0016491//GO:0003824//GO:0015930//GO:0046872 nitronate monooxygenase activity//indole-3-glycerol-phosphate synthase activity//N-acylglucosamine-6-phosphate 2-epimerase activity//oxidoreductase activity, acting on the CH-CH group of donors//oxidoreductase activity, acting on the CH-NH2 group of donors//IMP dehydrogenase activity//lyase activity//nucleotide binding//oxidoreductase activity//catalytic activity//glutamate synthase activity//metal ion binding GO:0005737//GO:0042720 cytoplasm//mitochondrial inner membrane peptidase complex KOG2550 IMP dehydrogenase/GMP reductase Cluster-8309.33470 BP_3 4.00 0.40 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33471 BP_3 1572.99 128.45 882 91084965 XP_971914.1 889 4.7e-93 PREDICTED: transmembrane emp24 domain-containing protein 2 [Tribolium castaneum]>gi|270009004|gb|EFA05452.1| hypothetical protein TcasGA2_TC015633 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7SXK3 719 1.0e-74 Transmembrane emp24 domain-containing protein OS=Nematostella vectensis GN=v1g194562 PE=3 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1692 Putative cargo transport protein EMP24 (p24 protein family) Cluster-8309.33474 BP_3 288.52 7.43 2163 270013786 EFA10234.1 1624 6.8e-178 hypothetical protein TcasGA2_TC012431 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JR59 232 7.2e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33475 BP_3 1424.21 59.73 1441 642933527 XP_008197456.1 898 7.0e-94 PREDICTED: protein alan shepard isoform X3 [Tribolium castaneum] 462283408 APGK01056946.1 55 1.71737e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 4.2e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF00076//PF09726//PF07267 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein//Nucleopolyhedrovirus capsid protein P87 -- -- GO:0003676 nucleic acid binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG4733 FOG: RRM domain Cluster-8309.33476 BP_3 17.78 0.42 2320 642916176 XP_008190917.1 2246 5.5e-250 PREDICTED: transcription factor 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BQ70 1132 3.4e-122 Transcription factor 25 OS=Homo sapiens GN=TCF25 PE=1 SV=1 PF06783 Uncharacterised protein family (UPF0239) -- -- -- -- GO:0016021 integral component of membrane KOG2422 Uncharacterized conserved protein Cluster-8309.33477 BP_3 192.71 1.19 8130 642923740 XP_008193866.1 1948 6.9e-215 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X8 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O35547 1209 1.4e-130 Long-chain-fatty-acid--CoA ligase 4 OS=Rattus norvegicus GN=Acsl4 PE=1 SV=1 PF09259//PF06624//PF00908//PF15138//PF00501 Fungal immunomodulatory protein Fve//Ribosome associated membrane protein RAMP4//dTDP-4-dehydrorhamnose 3,5-epimerase//Syncollin//AMP-binding enzyme GO:0002682//GO:0006887//GO:0009117//GO:0019872//GO:0008152//GO:0030639 regulation of immune system process//exocytosis//nucleotide metabolic process//streptomycin biosynthetic process//metabolic process//polyketide biosynthetic process GO:0008830//GO:0030246//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//carbohydrate binding//catalytic activity GO:0005783//GO:0030667 endoplasmic reticulum//secretory granule membrane KOG1180 Acyl-CoA synthetase Cluster-8309.33479 BP_3 2177.90 40.14 2907 642923730 XP_008193860.1 3102 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X3 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O95573 1652 2.1e-182 Long-chain-fatty-acid--CoA ligase 3 OS=Homo sapiens GN=ACSL3 PE=1 SV=3 PF00501//PF00908 AMP-binding enzyme//dTDP-4-dehydrorhamnose 3,5-epimerase GO:0008152//GO:0019872//GO:0030639//GO:0009117 metabolic process//streptomycin biosynthetic process//polyketide biosynthetic process//nucleotide metabolic process GO:0008830//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//catalytic activity -- -- KOG1180 Acyl-CoA synthetase Cluster-8309.33480 BP_3 1779.00 18.90 4829 817051760 XP_012252721.1 4480 0.0e+00 PREDICTED: protein strawberry notch isoform X2 [Athalia rosae] 751787619 XM_011204931.1 333 1.69045e-171 PREDICTED: Bactrocera dorsalis protein strawberry notch (LOC105226145), transcript variant X2, mRNA -- -- -- -- A3KN83 3450 0.0e+00 Protein strawberry notch homolog 1 OS=Homo sapiens GN=SBNO1 PE=1 SV=1 PF04851 Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding -- -- KOG1513 Nuclear helicase MOP-3/SNO (DEAD-box superfamily) Cluster-8309.33482 BP_3 221.42 1.32 8366 546677296 ERL88157.1 1170 1.2e-124 hypothetical protein D910_05545 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 376 5.6e-34 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33484 BP_3 11.00 2.06 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33486 BP_3 28.45 8.09 461 642912272 XP_008200632.1 155 3.2e-08 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.33489 BP_3 248.64 14.14 1139 579339789 EUT90581.1 143 1.9e-06 hypothetical protein PFAG_00937 [Plasmodium falciparum Santa Lucia] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33490 BP_3 1879.00 29.39 3373 270005992 EFA02440.1 870 2.9e-90 hypothetical protein TcasGA2_TC008127 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33491 BP_3 139.51 4.57 1762 260780876 XP_002585561.1 655 1.3e-65 hypothetical protein BRAFLDRAFT_133163 [Branchiostoma floridae]>gi|229270566|gb|EEN41572.1| hypothetical protein BRAFLDRAFT_133163 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96IR2 588 3.1e-59 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.33492 BP_3 28.30 0.74 2147 91089397 XP_974004.1 1576 2.5e-172 PREDICTED: pyridoxal-dependent decarboxylase domain-containing protein 1 [Tribolium castaneum]>gi|270011423|gb|EFA07871.1| hypothetical protein TcasGA2_TC005445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K01 450 3.8e-43 Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Mus musculus GN=Pdxdc1 PE=1 SV=2 PF00964 Elicitin GO:0019752//GO:0006952//GO:0009405 carboxylic acid metabolic process//defense response//pathogenesis GO:0030170//GO:0016831 pyridoxal phosphate binding//carboxy-lyase activity GO:0005576 extracellular region -- -- Cluster-8309.33494 BP_3 34.75 0.47 3874 91091444 XP_972566.1 1578 2.6e-172 PREDICTED: succinate-semialdehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270000977|gb|EEZ97424.1| hypothetical protein TcasGA2_TC011254 [Tribolium castaneum] -- -- -- -- -- K00139 ALDH5A1 succinate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00139 Q3MSM3 1099 3.8e-118 Succinate-semialdehyde dehydrogenase, mitochondrial OS=Hylobates lar GN=ALDH5A1 PE=2 SV=1 PF00171//PF00013 Aldehyde dehydrogenase family//KH domain GO:0008152//GO:0009450//GO:0055114//GO:0006570 metabolic process//gamma-aminobutyric acid catabolic process//oxidation-reduction process//tyrosine metabolic process GO:0009013//GO:0003723//GO:0016491 succinate-semialdehyde dehydrogenase [NAD(P)+] activity//RNA binding//oxidoreductase activity -- -- KOG2451 Aldehyde dehydrogenase Cluster-8309.33497 BP_3 245.69 2.37 5296 91090764 XP_969066.1 4523 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X3 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 3.7e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.33498 BP_3 308.00 29.67 792 762109106 XP_011437202.1 265 9.6e-21 PREDICTED: actin-like [Crassostrea gigas] 9501242 AJ292554.1 129 6.76568e-59 Daphnia magna mRNA for actin K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 O42161 265 3.9e-22 Actin, cytoplasmic 1 OS=Salmo salar GN=actb PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.33499 BP_3 710.00 18.55 2137 91077514 XP_969829.1 2169 4.3e-241 PREDICTED: ras association domain-containing protein 4 [Tribolium castaneum] 642914070 XM_964736.3 180 8.36363e-87 PREDICTED: Tribolium castaneum ras association domain-containing protein 4 (LOC658338), mRNA K09851 RASSF2_4 Ras association domain-containing protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K09851 Q566C5 331 2.4e-29 Ras association domain-containing protein 4 OS=Rattus norvegicus GN=Rassf4 PE=2 SV=1 PF16517//PF00788//PF00412 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain//Ras association (RalGDS/AF-6) domain//LIM domain GO:0007165 signal transduction GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.335 BP_3 7.00 0.39 1163 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33500 BP_3 22.88 0.70 1874 642940167 XP_008194639.1 623 7.0e-62 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXM1 253 2.3e-20 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens GN=LRIG3 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33501 BP_3 182.68 6.28 1694 642929884 XP_008196012.1 683 7.0e-69 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 214 6.9e-16 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33502 BP_3 258.22 16.31 1055 642915229 XP_008190531.1 936 2.0e-98 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 548 8.0e-55 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33503 BP_3 177.05 1.46 6138 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.1e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF01331//PF09266//PF01279//PF13606//PF00023 mRNA capping enzyme, catalytic domain//Viral DNA topoisomerase I, N-terminal//Parathyroid hormone family//Ankyrin repeat//Ankyrin repeat GO:0006397//GO:0007165//GO:0006265//GO:0006370 mRNA processing//signal transduction//DNA topological change//7-methylguanosine mRNA capping GO:0004484//GO:0005515//GO:0005179//GO:0003916//GO:0003677 mRNA guanylyltransferase activity//protein binding//hormone activity//DNA topoisomerase activity//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.33506 BP_3 794.00 37.22 1320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02109 DAD family GO:0018279 protein N-linked glycosylation via asparagine GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex -- -- Cluster-8309.33507 BP_3 69.00 2.91 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33509 BP_3 853.00 28.71 1724 270005400 EFA01848.1 166 6.3e-09 hypothetical protein TcasGA2_TC007451 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02234 Cyclin-dependent kinase inhibitor GO:0007050//GO:0045859 cell cycle arrest//regulation of protein kinase activity GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634 nucleus -- -- Cluster-8309.3351 BP_3 2.00 0.64 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33510 BP_3 3657.95 97.72 2096 642928891 XP_008195605.1 745 5.6e-76 PREDICTED: coatomer subunit zeta-1 [Tribolium castaneum] 346709586 AK384066.1 60 4.18285e-20 Bombyx mori mRNA, clone: fcaL06G10 -- -- -- -- P61923 549 1.2e-54 Coatomer subunit zeta-1 OS=Homo sapiens GN=COPZ1 PE=1 SV=1 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG3343 Vesicle coat complex COPI, zeta subunit Cluster-8309.33512 BP_3 262.98 2.42 5525 546686097 ERL95494.1 1149 2.1e-122 hypothetical protein D910_12756 [Dendroctonus ponderosae] 807033242 XM_004529566.2 72 2.37678e-26 PREDICTED: Ceratitis capitata TM2 domain-containing protein almondex (LOC101449885), mRNA -- -- -- -- Q9U4H5 654 2.2e-66 TM2 domain-containing protein almondex OS=Drosophila melanogaster GN=amx PE=2 SV=1 PF06743//PF05733 FAST kinase-like protein, subdomain 1//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0003723//GO:0004672 RNA binding//protein kinase activity GO:0019013 viral nucleocapsid KOG4272 Predicted GTP-binding protein Cluster-8309.33514 BP_3 145.50 1.80 4196 478257812 ENN77955.1 359 6.4e-31 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01155//PF04135 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Nucleolar RNA-binding protein, Nop10p family GO:0006464//GO:0001522//GO:0042254 cellular protein modification process//pseudouridine synthesis//ribosome biogenesis GO:0030515//GO:0016151 snoRNA binding//nickel cation binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.33515 BP_3 1383.31 12.33 5700 478263085 ENN81485.1 1571 2.5e-171 hypothetical protein YQE_02177, partial [Dendroctonus ponderosae] -- -- -- -- -- K03509 POLH DNA polymerase eta http://www.genome.jp/dbget-bin/www_bget?ko:K03509 Q9Y253 864 9.9e-91 DNA polymerase eta OS=Homo sapiens GN=POLH PE=1 SV=1 PF11799//PF00096//PF00817 impB/mucB/samB family C-terminal domain//Zinc finger, C2H2 type//impB/mucB/samB family GO:0006281 DNA repair GO:0003684//GO:0046872 damaged DNA binding//metal ion binding -- -- KOG2095 DNA polymerase iota/DNA damage inducible protein Cluster-8309.33518 BP_3 26.22 0.76 1957 642939029 XP_008200194.1 621 1.2e-61 PREDICTED: uncharacterized protein LOC103314860 [Tribolium castaneum]>gi|270016275|gb|EFA12721.1| hypothetical protein TcasGA2_TC002356 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D722 128 7.5e-06 Oxidative stress-responsive serine-rich protein 1 OS=Mus musculus GN=Oser1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33521 BP_3 8.02 0.33 1449 189234413 XP_975276.2 676 3.9e-68 PREDICTED: uncharacterized protein LOC664170 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33522 BP_3 1593.36 23.28 3590 642913459 XP_008201021.1 968 1.3e-101 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] -- -- -- -- -- K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q99K85 573 3.5e-57 Phosphoserine aminotransferase OS=Mus musculus GN=Psat1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.33525 BP_3 86.00 1.06 4220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08152 GUCT (NUC152) domain -- -- GO:0003723//GO:0004386//GO:0005524 RNA binding//helicase activity//ATP binding GO:0005634 nucleus -- -- Cluster-8309.33526 BP_3 978.00 8.62 5761 642923580 XP_008193569.1 3308 0.0e+00 PREDICTED: ankyrin-3 [Tribolium castaneum]>gi|642923582|ref|XP_008193570.1| PREDICTED: ankyrin-3 [Tribolium castaneum]>gi|270007684|gb|EFA04132.1| hypothetical protein TcasGA2_TC014376 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12955 235 8.7e-18 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF07525//PF16320//PF00023//PF13606//PF17076 SOCS box//Ribosomal protein L7/L12 dimerisation domain//Ankyrin repeat//Ankyrin repeat//SBE2, cell-qall formation GO:0006412//GO:0035556//GO:0042254//GO:0031505 translation//intracellular signal transduction//ribosome biogenesis//fungal-type cell wall organization GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG4177 Ankyrin Cluster-8309.33529 BP_3 415.00 44.82 738 91087993 XP_973641.1 512 2.0e-49 PREDICTED: protein aveugle [Tribolium castaneum]>gi|270011900|gb|EFA08348.1| hypothetical protein TcasGA2_TC005991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8ML92 316 4.5e-28 Protein aveugle OS=Drosophila melanogaster GN=ave PE=1 SV=1 PF07647//PF00536//PF02198 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.33530 BP_3 5587.94 23.40 11801 478257615 ENN77767.1 2921 0.0e+00 hypothetical protein YQE_05739, partial [Dendroctonus ponderosae]>gi|546673589|gb|ERL85158.1| hypothetical protein D910_02580 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VI25 2070 2.9e-230 Neurochondrin homolog OS=Drosophila melanogaster GN=Neurochondrin PE=2 SV=1 PF02028//PF00240//PF03810//PF01383//PF14560//PF03840//PF01728 BCCT, betaine/carnitine/choline family transporter//Ubiquitin family//Importin-beta N-terminal domain//CpcD/allophycocyanin linker domain//Ubiquitin-like domain//Preprotein translocase SecG subunit//FtsJ-like methyltransferase GO:0009306//GO:0006886//GO:0006810//GO:0032259//GO:0015031 protein secretion//intracellular protein transport//transport//methylation//protein transport GO:0005215//GO:0008536//GO:0005515//GO:0015450//GO:0008168 transporter activity//Ran GTPase binding//protein binding//P-P-bond-hydrolysis-driven protein transmembrane transporter activity//methyltransferase activity GO:0016021//GO:0009941//GO:0030089//GO:0016020 integral component of membrane//chloroplast envelope//phycobilisome//membrane KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ Cluster-8309.33531 BP_3 154.29 1.26 6191 478251874 ENN72313.1 897 3.9e-93 hypothetical protein YQE_11056, partial [Dendroctonus ponderosae] -- -- -- -- -- K13337 PEX19 peroxin-19 http://www.genome.jp/dbget-bin/www_bget?ko:K13337 Q9VJZ7 458 1.3e-43 Ribosomal RNA processing protein 1 homolog OS=Drosophila melanogaster GN=Nnp-1 PE=1 SV=1 PF00435//PF01347//PF05997//PF04614//PF02865 Spectrin repeat//Lipoprotein amino terminal region//Nucleolar protein,Nop52//Pex19 protein family//STAT protein, protein interaction domain GO:0006364//GO:0006355//GO:0006869//GO:0007165 rRNA processing//regulation of transcription, DNA-templated//lipid transport//signal transduction GO:0003700//GO:0004871//GO:0005515//GO:0005319 transcription factor activity, sequence-specific DNA binding//signal transducer activity//protein binding//lipid transporter activity GO:0005777//GO:0005667//GO:0030688 peroxisome//transcription factor complex//preribosome, small subunit precursor KOG3911 Nucleolar protein NOP52/RRP1 Cluster-8309.33532 BP_3 39.00 6.18 596 -- -- -- -- -- 58197573 AC154128.3 58 1.47591e-19 Tribolium castaneum BAC T.cast_C36A24 (Clemson University Genomics Institute Tribolium castaneum BAC Library (Red Flour Beetle)) complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33533 BP_3 266.76 56.05 521 91084415 XP_967749.1 497 7.9e-48 PREDICTED: macrophage migration inhibitory factor homolog [Tribolium castaneum]>gi|270008846|gb|EFA05294.1| hypothetical protein TcasGA2_TC015451 [Tribolium castaneum] -- -- -- -- -- K07253 MIF phenylpyruvate tautomerase http://www.genome.jp/dbget-bin/www_bget?ko:K07253 P91850 244 7.1e-20 Macrophage migration inhibitory factor homolog OS=Brugia malayi GN=Bm1_28435 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1759 Macrophage migration inhibitory factor Cluster-8309.33535 BP_3 152.81 16.32 743 642931962 XP_008196796.1 425 2.5e-39 PREDICTED: glutaredoxin-C4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K03676 grxC, GLRX, GLRX2 glutaredoxin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03676 Q8LFQ6 275 2.6e-23 Glutaredoxin-C4 OS=Arabidopsis thaliana GN=GRXC4 PE=2 SV=2 PF01323//PF00462//PF00085 DSBA-like thioredoxin domain//Glutaredoxin//Thioredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0009055//GO:0015035 electron carrier activity//protein disulfide oxidoreductase activity -- -- KOG1752 Glutaredoxin and related proteins Cluster-8309.33536 BP_3 85.47 6.27 949 478250587 ENN71079.1 476 3.9e-45 hypothetical protein YQE_12013, partial [Dendroctonus ponderosae]>gi|546672941|gb|ERL84649.1| hypothetical protein D910_02077 [Dendroctonus ponderosae] -- -- -- -- -- K03676 grxC, GLRX, GLRX2 glutaredoxin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03676 Q8LFQ6 277 1.9e-23 Glutaredoxin-C4 OS=Arabidopsis thaliana GN=GRXC4 PE=2 SV=2 PF01323//PF00462//PF00085 DSBA-like thioredoxin domain//Glutaredoxin//Thioredoxin GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG1752 Glutaredoxin and related proteins Cluster-8309.33537 BP_3 43.81 0.49 4613 642934565 XP_008197717.1 3558 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 847 7.5e-89 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0000166//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//nucleotide binding//protein kinase activity GO:0016020 membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.33538 BP_3 433.00 16.61 1548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33539 BP_3 58.19 1.04 2981 642919702 XP_008192028.1 2010 1.6e-222 PREDICTED: inositol-trisphosphate 3-kinase A-like [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 900 3.5e-95 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.33541 BP_3 858.00 63.31 945 332376134 AEE63207.1 824 1.7e-85 unknown [Dendroctonus ponderosae] 665816885 XM_008558965.1 93 8.3647e-39 PREDICTED: Microplitis demolitor ADP-ribosylation factor 1 (LOC103578032), mRNA K07939 ARF4 ADP-ribosylation factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K07939 P51644 765 4.9e-80 ADP-ribosylation factor 4 OS=Xenopus laevis GN=arf4 PE=1 SV=2 PF00025//PF04670//PF00071//PF00503//PF01591//PF01926//PF08477 ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//6-phosphofructo-2-kinase//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0007186//GO:0006013//GO:0007264//GO:0006000 signal transduction//G-protein coupled receptor signaling pathway//mannose metabolic process//small GTPase mediated signal transduction//fructose metabolic process GO:0005524//GO:0031683//GO:0003873//GO:0003924//GO:0005525//GO:0019001//GO:0004871 ATP binding//G-protein beta/gamma-subunit complex binding//6-phosphofructo-2-kinase activity//GTPase activity//GTP binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.33542 BP_3 55.67 0.70 4144 642911681 XP_008200699.1 3110 0.0e+00 PREDICTED: stAR-related lipid transfer protein 13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q923Q2 1160 3.4e-125 StAR-related lipid transfer protein 13 OS=Mus musculus GN=Stard13 PE=1 SV=5 PF01852//PF07647//PF00620//PF03121 START domain//SAM domain (Sterile alpha motif)//RhoGAP domain//Herpesviridae UL52/UL70 DNA primase GO:0006260//GO:0006269//GO:0006351//GO:0007165 DNA replication//DNA replication, synthesis of RNA primer//transcription, DNA-templated//signal transduction GO:0003896//GO:0008289//GO:0005515 DNA primase activity//lipid binding//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 Cluster-8309.33543 BP_3 407.88 6.12 3503 558201797 XP_006131692.1 250 2.3e-18 PREDICTED: zinc finger protein 135-like, partial [Pelodiscus sinensis] 667677333 AE014297.3 36 1.54433e-06 Drosophila melanogaster chromosome 3R K09208 KLF9S, BTEB krueppel-like factor 9/13/14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K09208 Q9Y2Y9 455 1.6e-43 Krueppel-like factor 13 OS=Homo sapiens GN=KLF13 PE=1 SV=1 PF13912//PF13465//PF02176//PF00096 C2H2-type zinc finger//Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.33545 BP_3 8.71 0.46 1206 642934605 XP_971300.2 782 1.6e-80 PREDICTED: CD63 antigen [Tribolium castaneum] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q9XSK2 375 1.1e-34 CD63 antigen OS=Bos taurus GN=CD63 PE=2 SV=4 PF13520//PF00335//PF05149//PF00115//PF09004 Amino acid permease//Tetraspanin family//Paraflagellar rod protein//Cytochrome C and Quinol oxidase polypeptide I//Domain of unknown function (DUF1891) GO:0003333//GO:0006865//GO:0015992//GO:0055114//GO:0006118//GO:0009060//GO:0006123 amino acid transmembrane transport//amino acid transport//proton transport//oxidation-reduction process//obsolete electron transport//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0020037//GO:0016706//GO:0009055//GO:0005506//GO:0008168//GO:0015171//GO:0005516 cytochrome-c oxidase activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//electron carrier activity//iron ion binding//methyltransferase activity//amino acid transmembrane transporter activity//calmodulin binding GO:0016020//GO:0045277//GO:0031514//GO:0016021 membrane//respiratory chain complex IV//motile cilium//integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.33547 BP_3 117.77 6.52 1162 642938589 XP_008199854.1 397 7.0e-36 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X3 [Tribolium castaneum] 642938588 XM_008201632.1 200 3.41781e-98 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0005388 calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum -- -- Cluster-8309.33548 BP_3 10505.21 457.29 1399 642912129 XP_966308.2 889 7.5e-93 PREDICTED: peptidyl-prolyl cis-trans isomerase [Tribolium castaneum] 755876427 XM_005183940.2 169 7.07038e-81 PREDICTED: Musca domestica peptidyl-prolyl cis-trans isomerase (LOC101898665), mRNA K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 P54985 780 1.3e-81 Peptidyl-prolyl cis-trans isomerase OS=Blattella germanica GN=CYPA PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.33550 BP_3 273.00 18.74 994 189234428 XP_001816488.1 642 2.3e-64 PREDICTED: coatomer subunit beta [Tribolium castaneum]>gi|270001762|gb|EEZ98209.1| hypothetical protein TcasGA2_TC000641 [Tribolium castaneum] -- -- -- -- -- K17301 COPB1, SEC26 coatomer, subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17301 Q5ZIA5 545 1.7e-54 Coatomer subunit beta OS=Gallus gallus GN=COPB1 PE=2 SV=1 PF01602 Adaptin N terminal region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198 structural molecule activity GO:0030126//GO:0030117 COPI vesicle coat//membrane coat KOG1058 Vesicle coat complex COPI, beta subunit Cluster-8309.33551 BP_3 2290.42 48.65 2561 189234428 XP_001816488.1 3625 0.0e+00 PREDICTED: coatomer subunit beta [Tribolium castaneum]>gi|270001762|gb|EEZ98209.1| hypothetical protein TcasGA2_TC000641 [Tribolium castaneum] 821408518 XM_004279158.2 125 3.77161e-56 PREDICTED: Orcinus orca coatomer protein complex, subunit beta 1 (COPB1), mRNA K17301 COPB1, SEC26 coatomer, subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17301 P45437 2916 0.0e+00 Coatomer subunit beta OS=Drosophila melanogaster GN=betaCop PE=2 SV=2 PF02985//PF01602//PF07718//PF00514 HEAT repeat//Adaptin N terminal region//Coatomer beta C-terminal region//Armadillo/beta-catenin-like repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG1058 Vesicle coat complex COPI, beta subunit Cluster-8309.33552 BP_3 183.26 2.32 4101 642931115 XP_008201667.1 421 4.1e-38 PREDICTED: autism susceptibility gene 2 protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08597//PF06459//PF04617 Translation initiation factor eIF3 subunit//Ryanodine Receptor TM 4-6//Hox9 activation region GO:0006446//GO:0006816//GO:0006351//GO:0006874 regulation of translational initiation//calcium ion transport//transcription, DNA-templated//cellular calcium ion homeostasis GO:0005219//GO:0003743 ryanodine-sensitive calcium-release channel activity//translation initiation factor activity GO:0016021//GO:0005634//GO:0005737//GO:0005852//GO:0005622//GO:0005840 integral component of membrane//nucleus//cytoplasm//eukaryotic translation initiation factor 3 complex//intracellular//ribosome -- -- Cluster-8309.33553 BP_3 25.16 0.56 2444 91077452 XP_967401.1 1566 4.1e-171 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270001620|gb|EEZ98067.1| hypothetical protein TcasGA2_TC000474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02338 463 1.3e-44 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3 PF13676//PF01370//PF00106 TIR domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152//GO:0007165//GO:0055114 metabolic process//signal transduction//oxidation-reduction process GO:0003824//GO:0050662//GO:0005515//GO:0016491//GO:0000166 catalytic activity//coenzyme binding//protein binding//oxidoreductase activity//nucleotide binding -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.33554 BP_3 18.00 1.71 798 348509041 XP_003442060.1 499 7.1e-48 PREDICTED: 60S ribosomal protein L19-like [Oreochromis niloticus]>gi|498991023|ref|XP_004552409.1| PREDICTED: 60S ribosomal protein L19 [Maylandia zebra]>gi|548347617|ref|XP_005726204.1| PREDICTED: 60S ribosomal protein L19-like [Pundamilia nyererei]>gi|554822560|ref|XP_005921974.1| PREDICTED: 60S ribosomal protein L19-like [Haplochromis burtoni]>gi|584006766|ref|XP_006798361.1| PREDICTED: 60S ribosomal protein L19-like [Neolamprologus brichardi] 697089560 XM_009659394.1 736 0 Verticillium dahliae VdLs.17 60S ribosomal protein L19 mRNA K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 O42699 544 1.8e-54 60S ribosomal protein L19-B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl1902 PE=2 SV=2 PF01280 Ribosomal protein L19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1696 60s ribosomal protein L19 Cluster-8309.33557 BP_3 111.32 0.93 6063 332372732 AEE61508.1 572 1.9e-55 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 396 2.0e-36 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF03370//PF15826//PF02936//PF08294//PF00191 Carbohydrate/starch-binding module (family 21)//Bcl-2-binding component 3, p53 upregulated modulator of apoptosis//Cytochrome c oxidase subunit IV//TIM21//Annexin GO:0043065//GO:0015992//GO:0090200//GO:0006123//GO:0097193//GO:0030150 positive regulation of apoptotic process//proton transport//positive regulation of release of cytochrome c from mitochondria//mitochondrial electron transport, cytochrome c to oxygen//intrinsic apoptotic signaling pathway//protein import into mitochondrial matrix GO:0005509//GO:0004129//GO:0005544//GO:0005515 calcium ion binding//cytochrome-c oxidase activity//calcium-dependent phospholipid binding//protein binding GO:0005739//GO:0005744//GO:0045277 mitochondrion//mitochondrial inner membrane presequence translocase complex//respiratory chain complex IV KOG0819 Annexin Cluster-8309.33558 BP_3 100.61 0.87 5861 332372732 AEE61508.1 681 4.1e-68 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 464 2.5e-44 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF08294//PF02936//PF00191//PF15826//PF03370 TIM21//Cytochrome c oxidase subunit IV//Annexin//Bcl-2-binding component 3, p53 upregulated modulator of apoptosis//Carbohydrate/starch-binding module (family 21) GO:0030150//GO:0097193//GO:0006123//GO:0043065//GO:0090200//GO:0015992 protein import into mitochondrial matrix//intrinsic apoptotic signaling pathway//mitochondrial electron transport, cytochrome c to oxygen//positive regulation of apoptotic process//positive regulation of release of cytochrome c from mitochondria//proton transport GO:0005515//GO:0005544//GO:0004129//GO:0005509 protein binding//calcium-dependent phospholipid binding//cytochrome-c oxidase activity//calcium ion binding GO:0045277//GO:0005744//GO:0005739 respiratory chain complex IV//mitochondrial inner membrane presequence translocase complex//mitochondrion KOG0819 Annexin Cluster-8309.33559 BP_3 21.00 0.42 2727 646719839 KDR21809.1 174 1.2e-09 hypothetical protein L798_02611, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q7KQZ4 154 1.0e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF16622//PF00253 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0046872 structural constituent of ribosome//metal ion binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.33560 BP_3 21.23 0.57 2092 642935333 XP_008197972.1 674 9.5e-68 PREDICTED: uncharacterized protein LOC100142013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 404 8.0e-38 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 PF02170 PAZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33561 BP_3 387.50 28.33 951 150416593 ABF60889.2 161 1.3e-08 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07941 Potassium channel Kv1.4 tandem inactivation domain GO:0006813 potassium ion transport GO:0005249//GO:0030955 voltage-gated potassium channel activity//potassium ion binding GO:0008076//GO:0016021 voltage-gated potassium channel complex//integral component of membrane -- -- Cluster-8309.33562 BP_3 17.47 0.41 2339 91087837 XP_967757.1 988 4.1e-104 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 691 4.7e-71 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF06756//PF01370//PF01118//PF01073 Chorion protein S19 C-terminal//NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0007275//GO:0008210//GO:0008207//GO:0055114//GO:0006694//GO:0008209 multicellular organismal development//estrogen metabolic process//C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process GO:0003854//GO:0050662//GO:0003824//GO:0051287//GO:0016616//GO:0016620 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0042600 chorion -- -- Cluster-8309.33563 BP_3 1325.39 45.30 1702 91087837 XP_967757.1 1441 8.9e-157 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 783 7.3e-82 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF06756//PF01118//PF01073//PF01370 Male sterility protein//Chorion protein S19 C-terminal//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008210//GO:0007275//GO:0008207//GO:0006694//GO:0055114//GO:0008209 estrogen metabolic process//multicellular organismal development//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process GO:0003854//GO:0003824//GO:0050662//GO:0051287//GO:0016616//GO:0080019//GO:0016620 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0042600 chorion -- -- Cluster-8309.33564 BP_3 69.82 1.05 3489 91078972 XP_974414.1 2195 6.8e-244 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 Q05187 1344 1.3e-146 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.33565 BP_3 2699.92 28.47 4863 546683392 ERL93211.1 2662 6.7e-298 hypothetical protein D910_10507, partial [Dendroctonus ponderosae] 795040839 XM_012011345.1 78 9.65586e-30 PREDICTED: Vollenhovia emeryi integrin beta-PS (LOC105561398), transcript variant X2, mRNA K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 2143 4.2e-239 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 PF03325//PF01437 Herpesvirus polymerase accessory protein//Plexin repeat GO:0019079//GO:0006260 viral genome replication//DNA replication GO:0030337 DNA polymerase processivity factor activity GO:0042575//GO:0016020 DNA polymerase complex//membrane KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.33567 BP_3 96.89 3.29 1711 646710939 KDR16317.1 278 6.5e-22 Eukaryotic translation initiation factor 3 subunit G [Zootermopsis nevadensis] -- -- -- -- -- K03248 EIF3G translation initiation factor 3 subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K03248 Q9VDM6 248 8.0e-20 Eukaryotic translation initiation factor 3 subunit G-2 OS=Drosophila melanogaster GN=eIF3-S4-2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.33568 BP_3 40.69 1.31 1784 546681436 ERL91533.1 629 1.3e-62 hypothetical protein D910_08863 [Dendroctonus ponderosae] -- -- -- -- -- K12199 VTA1, LIP5 vacuolar protein sorting-associated protein VTA1 http://www.genome.jp/dbget-bin/www_bget?ko:K12199 Q32L63 405 5.2e-38 Vacuolar protein sorting-associated protein VTA1 homolog OS=Bos taurus GN=VTA1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0917 Uncharacterized conserved protein Cluster-8309.33570 BP_3 20.19 0.56 2045 189234402 XP_974971.2 2606 8.7e-292 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96KG7 1504 2.2e-165 Multiple epidermal growth factor-like domains protein 10 OS=Homo sapiens GN=MEGF10 PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.33571 BP_3 1415.60 38.85 2048 189238048 XP_001811309.1 1728 5.6e-190 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 1.4e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF01370//PF01073//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0003854//GO:0050662//GO:0003824//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.33574 BP_3 2705.00 72.58 2088 282165699 NP_001107796.2 2156 1.3e-239 Sterol carrier protein X-related thiolase [Tribolium castaneum]>gi|270015166|gb|EFA11614.1| sterol carrier protein x [Tribolium castaneum] 666417103 LL712009.1 38 7.07158e-08 Elaeophora elaphi genome assembly E_elaphi ,scaffold EEL_contig0000408 K08764 SCP2, SCPX sterol carrier protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08764 O62742 1615 3.0e-178 Non-specific lipid-transfer protein OS=Oryctolagus cuniculus GN=SCP2 PE=1 SV=1 PF08545//PF00108//PF02803 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain//Thiolase, C-terminal domain GO:0006633//GO:0008152//GO:0042967 fatty acid biosynthetic process//metabolic process//acyl-carrier-protein biosynthetic process GO:0032934//GO:0004315//GO:0016747 sterol binding//3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1406 Peroxisomal 3-ketoacyl-CoA-thiolase P-44/SCP2 Cluster-8309.33576 BP_3 21.83 0.31 3720 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 7.2e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00989//PF00072//PF05504//PF00233//PF09771 PAS fold//Response regulator receiver domain//Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188 GO:0007165//GO:0000160//GO:0035307//GO:0006144//GO:0009847//GO:0006355 signal transduction//phosphorelay signal transduction system//positive regulation of protein dephosphorylation//purine nucleobase metabolic process//spore germination//regulation of transcription, DNA-templated GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0016020//GO:0071595 membrane//Nem1-Spo7 phosphatase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.33578 BP_3 217.55 14.60 1010 642922332 XP_008193116.1 1025 9.1e-109 PREDICTED: prickle-like protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43900 436 7.5e-42 Prickle-like protein 3 OS=Homo sapiens GN=PRICKLE3 PE=1 SV=2 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.33579 BP_3 66.74 0.89 3918 91088343 XP_971105.1 967 1.9e-101 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] 755959155 XM_011306001.1 66 3.63858e-23 PREDICTED: Fopius arisanus 60S ribosomal protein L38 (LOC105267271), mRNA K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 670 2.1e-68 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF02737//PF11857//PF01370//PF01781//PF02826//PF02882//PF12242 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Domain of unknown function (DUF3377)//NAD dependent epimerase/dehydratase family//Ribosomal L38e protein family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0006412//GO:0008152//GO:0006633//GO:0018874//GO:0006552//GO:0006631//GO:0046487//GO:0009396//GO:0006574//GO:0006550//GO:0055114//GO:0042254//GO:0006554//GO:0006568 translation//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//leucine catabolic process//fatty acid metabolic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//valine catabolic process//isoleucine catabolic process//oxidation-reduction process//ribosome biogenesis//lysine catabolic process//tryptophan metabolic process GO:0051287//GO:0016491//GO:0003824//GO:0004488//GO:0004222//GO:0050662//GO:0003735//GO:0000166//GO:0003857 NAD binding//oxidoreductase activity//catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//metalloendopeptidase activity//coenzyme binding//structural constituent of ribosome//nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.33580 BP_3 177.07 4.17 2337 91078348 XP_973652.1 1386 2.9e-150 PREDICTED: prostaglandin E synthase 2 [Tribolium castaneum]>gi|270003893|gb|EFA00341.1| hypothetical protein TcasGA2_TC003180 [Tribolium castaneum] -- -- -- -- -- K05309 PTGES2 microsomal prostaglandin-E synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05309 Q9N0A4 674 4.4e-69 Prostaglandin E synthase 2 OS=Macaca fascicularis GN=PTGES2 PE=1 SV=1 PF02798//PF00462//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG3029 Glutathione S-transferase-related protein Cluster-8309.33581 BP_3 512.90 8.33 3258 91077232 XP_968256.1 2161 5.5e-240 PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|642913746|ref|XP_008201143.1| PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|270002085|gb|EEZ98532.1| hypothetical protein TcasGA2_TC001036 [Tribolium castaneum] 780675948 XM_011698114.1 402 0 PREDICTED: Wasmannia auropunctata fizzy-related protein homolog (LOC105455066), mRNA K03364 CDH1 cell division cycle 20-like protein 1, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03364 Q9R1K5 1593 1.7e-175 Fizzy-related protein homolog OS=Mus musculus GN=Fzr1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.33582 BP_3 399.00 6.94 3061 332373526 AEE61904.1 1352 3.3e-146 unknown [Dendroctonus ponderosae]>gi|478254046|gb|ENN74338.1| hypothetical protein YQE_09308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBX0 704 1.9e-72 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF00106//PF03435//PF01370 short chain dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG2733 Uncharacterized membrane protein Cluster-8309.33583 BP_3 587.99 3.06 9555 332373526 AEE61904.1 1287 3.6e-138 unknown [Dendroctonus ponderosae]>gi|478254046|gb|ENN74338.1| hypothetical protein YQE_09308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBX0 654 3.7e-66 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF01728//PF07941//PF01370//PF03435//PF00089//PF01073//PF00106//PF05706 FtsJ-like methyltransferase//Potassium channel Kv1.4 tandem inactivation domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//Trypsin//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006508//GO:0032259//GO:0008152//GO:0008210//GO:0006813//GO:0006470//GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0006570 proteolysis//methylation//metabolic process//estrogen metabolic process//potassium ion transport//protein dephosphorylation//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//tyrosine metabolic process GO:0004721//GO:0030955//GO:0003824//GO:0004725//GO:0016491//GO:0008168//GO:0005249//GO:0004252//GO:0003854//GO:0050662//GO:0016616 phosphoprotein phosphatase activity//potassium ion binding//catalytic activity//protein tyrosine phosphatase activity//oxidoreductase activity//methyltransferase activity//voltage-gated potassium channel activity//serine-type endopeptidase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0008076//GO:0016021 voltage-gated potassium channel complex//integral component of membrane KOG2733 Uncharacterized membrane protein Cluster-8309.33585 BP_3 96.81 3.22 1741 91086225 XP_972341.1 2192 7.5e-244 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 766937068 XM_011502671.1 253 1.78347e-127 PREDICTED: Ceratosolen solmsi marchali dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (LOC105364681), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 1784 6.3e-198 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016020 oligosaccharyltransferase complex//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.33586 BP_3 3717.45 76.30 2640 91086225 XP_972341.1 3634 0.0e+00 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 766937068 XM_011502671.1 253 2.72329e-127 PREDICTED: Ceratosolen solmsi marchali dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (LOC105364681), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 2940 0.0e+00 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0016020//GO:0008250 membrane//oligosaccharyltransferase complex KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.33587 BP_3 179.12 8.16 1350 642917784 XP_008191285.1 1610 1.8e-176 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X2 [Tribolium castaneum] 170065886 XM_001868022.1 344 3.56115e-178 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 1558 7.9e-172 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.33588 BP_3 92.39 2.57 2022 642916687 XP_001813051.2 1031 3.7e-109 PREDICTED: putative hydroxypyruvate isomerase [Tribolium castaneum]>gi|642916689|ref|XP_008192173.1| PREDICTED: putative hydroxypyruvate isomerase [Tribolium castaneum]>gi|270004988|gb|EFA01436.1| hypothetical protein TcasGA2_TC030659 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 5.1e-58 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 -- -- GO:0046487 glyoxylate metabolic process GO:0008903 hydroxypyruvate isomerase activity -- -- KOG4518 Hydroxypyruvate isomerase Cluster-8309.33591 BP_3 56.56 3.90 991 642932529 XP_008197152.1 340 2.4e-29 PREDICTED: type-1 angiotensin II receptor-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33592 BP_3 6.00 3.06 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33594 BP_3 57.00 5.94 754 642938165 XP_008190990.1 225 4.0e-16 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.33595 BP_3 16.30 0.55 1717 189235434 XP_001813433.1 1605 8.7e-176 PREDICTED: paraplegin [Tribolium castaneum]>gi|270004289|gb|EFA00737.1| hypothetical protein TcasGA2_TC003619 [Tribolium castaneum] 242019804 XM_002430304.1 38 5.79366e-08 Pediculus humanus corporis conserved hypothetical protein, mRNA K09552 SPG7 spastic paraplegia 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09552 Q9UQ90 1125 1.6e-121 Paraplegin OS=Homo sapiens GN=SPG7 PE=1 SV=2 PF01434//PF00004 Peptidase family M41//ATPase family associated with various cellular activities (AAA) GO:0030163//GO:0006508 protein catabolic process//proteolysis GO:0017111//GO:0008270//GO:0005524//GO:0004222 nucleoside-triphosphatase activity//zinc ion binding//ATP binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.33596 BP_3 6.00 0.88 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33598 BP_3 39.25 0.54 3764 91081301 XP_968960.1 3902 0.0e+00 PREDICTED: glycogen phosphorylase [Tribolium castaneum]>gi|270006093|gb|EFA02541.1| hypothetical protein TcasGA2_TC008246 [Tribolium castaneum] 817087305 XM_012410997.1 451 0 PREDICTED: Athalia rosae glycogen phosphorylase (LOC105692065), mRNA K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 P11216 3201 0.0e+00 Glycogen phosphorylase, brain form OS=Homo sapiens GN=PYGB PE=1 SV=5 PF00343 Carbohydrate phosphorylase GO:0005975 carbohydrate metabolic process GO:0008184//GO:0030170 glycogen phosphorylase activity//pyridoxal phosphate binding -- -- KOG2099 Glycogen phosphorylase Cluster-8309.33600 BP_3 434.00 49.07 718 91081077 XP_975460.1 633 1.9e-63 PREDICTED: UPF0587 protein CG4646 [Tribolium castaneum]>gi|642920128|ref|XP_008192218.1| PREDICTED: UPF0587 protein CG4646 [Tribolium castaneum]>gi|642920130|ref|XP_008192219.1| PREDICTED: UPF0587 protein CG4646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9A2 477 9.4e-47 UPF0587 protein CG4646 OS=Drosophila melanogaster GN=CG4646 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1296 Uncharacterized conserved protein Cluster-8309.33602 BP_3 401.71 7.62 2834 642925355 XP_008194516.1 3769 0.0e+00 PREDICTED: integrator complex subunit 2 [Tribolium castaneum]>gi|270008723|gb|EFA05171.1| hypothetical protein TcasGA2_TC015300 [Tribolium castaneum] 642925354 XM_008196294.1 497 0 PREDICTED: Tribolium castaneum integrator complex subunit 2 (LOC661595), mRNA K13139 INTS2 integrator complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13139 Q9H0H0 1934 4.2e-215 Integrator complex subunit 2 OS=Homo sapiens GN=INTS2 PE=1 SV=2 PF03391//PF14750//PF07527 Nepovirus coat protein, central domain//Integrator complex subunit 2//Hairy Orange GO:0016180//GO:0006355 snRNA processing//regulation of transcription, DNA-templated GO:0005198//GO:0003677 structural molecule activity//DNA binding GO:0019028//GO:0032039 viral capsid//integrator complex -- -- Cluster-8309.33606 BP_3 86.98 1.70 2762 546686007 ERL95413.1 3162 0.0e+00 hypothetical protein D910_12677 [Dendroctonus ponderosae] 288872186 NM_001172404.1 254 7.92097e-128 Apis mellifera NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (Ndufs1), mRNA K03934 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03934 Q94511 2538 3.7e-285 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND75 PE=2 SV=3 PF00384//PF00205//PF00211//PF10588//PF00111//PF09326 Molybdopterin oxidoreductase//Thiamine pyrophosphate enzyme, central domain//Adenylate and Guanylate cyclase catalytic domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//2Fe-2S iron-sulfur cluster binding domain//NADH-ubiquinone oxidoreductase subunit G, C-terminal GO:0009190//GO:0055114//GO:0035556//GO:0006118 cyclic nucleotide biosynthetic process//oxidation-reduction process//intracellular signal transduction//obsolete electron transport GO:0030976//GO:0000287//GO:0016849//GO:0051536//GO:0009055//GO:0016491//GO:0016651 thiamine pyrophosphate binding//magnesium ion binding//phosphorus-oxygen lyase activity//iron-sulfur cluster binding//electron carrier activity//oxidoreductase activity//oxidoreductase activity, acting on NAD(P)H -- -- KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit Cluster-8309.33610 BP_3 1095.50 30.86 2003 642923805 XP_008193890.1 1839 7.4e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 3.9e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.33611 BP_3 393.85 8.75 2462 642927244 XP_974103.2 1078 1.6e-114 PREDICTED: stromal membrane-associated protein 1-like [Tribolium castaneum] -- -- -- -- -- K12486 SMAP stromal membrane-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K12486 Q5EA00 525 8.7e-52 Stromal membrane-associated protein 2 OS=Bos taurus GN=SMAP2 PE=2 SV=1 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0703 Predicted GTPase-activating protein Cluster-8309.33612 BP_3 140.30 1.21 5865 752891325 XP_011263696.1 1451 2.1e-157 PREDICTED: uncharacterized protein LOC105255869 [Camponotus floridanus] 752891324 XM_011265394.1 390 0 PREDICTED: Camponotus floridanus uncharacterized LOC105255869 (LOC105255869), mRNA -- -- -- -- -- -- -- -- PF07927 HicA toxin of bacterial toxin-antitoxin, -- -- GO:0003729 mRNA binding -- -- -- -- Cluster-8309.33613 BP_3 28.00 4.54 589 501291907 BAN20426.1 620 4.9e-62 ribosomal protein L17 [Riptortus pedestris] -- -- -- -- -- K02880 RP-L17e, RPL17 large subunit ribosomal protein L17e http://www.genome.jp/dbget-bin/www_bget?ko:K02880 A8CAG3 592 3.5e-60 60S ribosomal protein L17 OS=Phlebotomus papatasi GN=RpL17 PE=2 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3353 60S ribosomal protein L22 Cluster-8309.33614 BP_3 1569.00 88.11 1150 270012376 EFA08824.1 491 8.7e-47 hypothetical protein TcasGA2_TC006521 [Tribolium castaneum] 734646853 XM_010754281.1 52 6.34411e-16 PREDICTED: Larimichthys crocea cytochrome c oxidase subunit 6A, mitochondrial-like (LOC104937958), mRNA K02266 COX6A cytochrome c oxidase subunit 6a http://www.genome.jp/dbget-bin/www_bget?ko:K02266 P12074 286 2.1e-24 Cytochrome c oxidase subunit 6A1, mitochondrial OS=Homo sapiens GN=COX6A1 PE=1 SV=4 PF02046 Cytochrome c oxidase subunit VIa GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0005751//GO:0045277 mitochondrial inner membrane//mitochondrial respiratory chain complex IV//respiratory chain complex IV KOG3469 Cytochrome c oxidase, subunit VIa/COX13 Cluster-8309.33616 BP_3 159.47 2.83 3011 478256359 ENN76549.1 1496 6.6e-163 hypothetical protein YQE_07000, partial [Dendroctonus ponderosae]>gi|546680788|gb|ERL90994.1| hypothetical protein D910_08336 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 274 1.4e-22 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33617 BP_3 2481.19 32.42 3980 91092324 XP_970273.1 2461 1.1e-274 PREDICTED: vacuolar protein sorting-associated protein 45 [Tribolium castaneum]>gi|270015700|gb|EFA12148.1| hypothetical protein TcasGA2_TC002297 [Tribolium castaneum] -- -- -- -- -- K12479 VPS45 vacuolar protein sorting-associated protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K12479 P97390 1725 1.0e-190 Vacuolar protein sorting-associated protein 45 OS=Mus musculus GN=Vps45 PE=1 SV=1 PF02840//PF01546//PF00995//PF15184 Prp18 domain//Peptidase family M20/M25/M40//Sec1 family//Mitochondrial import receptor subunit TOM6 homolog GO:0008152//GO:0006281//GO:0016192//GO:0008380//GO:0006904 metabolic process//DNA repair//vesicle-mediated transport//RNA splicing//vesicle docking involved in exocytosis GO:0003677//GO:0016787 DNA binding//hydrolase activity GO:0005681//GO:0005742 spliceosomal complex//mitochondrial outer membrane translocase complex KOG2276 Metalloexopeptidases Cluster-8309.33619 BP_3 54.74 0.58 4842 642926741 XP_008194993.1 1564 1.4e-170 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X3 [Tribolium castaneum] 611988503 XM_007481079.1 71 7.48473e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 960 6.2e-102 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF00610//PF08001//PF00595//PF13180 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//CMV US//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0030683//GO:0035556 evasion or tolerance by virus of host immune response//intracellular signal transduction GO:0005515 protein binding GO:0044386 integral to host endoplasmic reticulum membrane KOG3571 Dishevelled 3 and related proteins Cluster-8309.33622 BP_3 47.60 0.69 3600 861660122 KMR04875.1 183 1.4e-10 longitudinals lacking isoforms a b d l [Lasius niger] -- -- -- -- -- -- -- -- -- Q7KQZ4 149 5.1e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF17123//PF13912//PF16622//PF01096//PF00096//PF13465//PF01155 RING-like zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006351 cellular protein modification process//transcription, DNA-templated GO:0003676//GO:0008270//GO:0046872//GO:0005515//GO:0016151 nucleic acid binding//zinc ion binding//metal ion binding//protein binding//nickel cation binding -- -- -- -- Cluster-8309.33625 BP_3 564.58 8.74 3404 270003289 EEZ99736.1 3087 0.0e+00 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.12739e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00130//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.33628 BP_3 18.24 0.49 2085 332376817 AEE63548.1 657 8.9e-66 unknown [Dendroctonus ponderosae] -- -- -- -- -- K19373 DNAJC28 DnaJ homolog subfamily C member 28 http://www.genome.jp/dbget-bin/www_bget?ko:K19373 Q8VCE1 341 1.6e-30 DnaJ homolog subfamily C member 28 OS=Mus musculus GN=Dnajc28 PE=2 SV=2 PF07574 Nse1 non-SMC component of SMC5-6 complex GO:0006281 DNA repair -- -- GO:0030915 Smc5-Smc6 complex KOG0568 Molecular chaperone (DnaJ superfamily) Cluster-8309.3363 BP_3 2.00 0.41 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33630 BP_3 65.39 1.31 2689 478256386 ENN76576.1 571 1.1e-55 hypothetical protein YQE_07025, partial [Dendroctonus ponderosae]>gi|546680818|gb|ERL91024.1| hypothetical protein D910_08366 [Dendroctonus ponderosae] -- -- -- -- -- K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q9VU70 394 1.5e-36 Tetratricopeptide repeat protein 36 homolog OS=Drosophila melanogaster GN=CG14105 PE=1 SV=1 PF13371//PF00515//PF13374//PF13414//PF05887//PF03839//PF13181//PF01414//PF05434 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Procyclic acidic repetitive protein (PARP)//Translocation protein Sec62//Tetratricopeptide repeat//Delta serrate ligand//TMEM9 GO:0015031//GO:0007154 protein transport//cell communication GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG2927 Membrane component of ER protein translocation complex Cluster-8309.33632 BP_3 3615.55 79.24 2491 157135017 XP_001656503.1 773 3.8e-79 AAEL013226-PA [Aedes aegypti]>gi|108870320|gb|EAT34545.1| AAEL013226-PA [Aedes aegypti] -- -- -- -- -- K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q9VU70 394 1.4e-36 Tetratricopeptide repeat protein 36 homolog OS=Drosophila melanogaster GN=CG14105 PE=1 SV=1 PF05887//PF13414//PF00515//PF13374//PF13371//PF05434//PF03169//PF05132//PF13181//PF03839 Procyclic acidic repetitive protein (PARP)//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TMEM9//OPT oligopeptide transporter protein//RNA polymerase III RPC4//Tetratricopeptide repeat//Translocation protein Sec62 GO:0006144//GO:0006383//GO:0006351//GO:0055085//GO:0015031//GO:0006206 purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//transmembrane transport//protein transport//pyrimidine nucleobase metabolic process GO:0005515//GO:0003899//GO:0003677//GO:0008565 protein binding//DNA-directed RNA polymerase activity//DNA binding//protein transporter activity GO:0016021//GO:0005730//GO:0005666//GO:0016020 integral component of membrane//nucleolus//DNA-directed RNA polymerase III complex//membrane KOG2927 Membrane component of ER protein translocation complex Cluster-8309.33633 BP_3 65.47 1.53 2350 478256696 ENN76878.1 1106 8.6e-118 hypothetical protein YQE_06719, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5E9V4 469 2.6e-45 Protein RRNAD1 OS=Bos taurus GN=RRNAD1 PE=2 SV=1 PF08123 Histone methylation protein DOT1 GO:0006479//GO:0006554 protein methylation//lysine catabolic process GO:0018024 histone-lysine N-methyltransferase activity -- -- KOG2651 rRNA adenine N-6-methyltransferase Cluster-8309.33634 BP_3 432.00 16.13 1583 642928334 XP_008195539.1 388 1.0e-34 PREDICTED: lysozyme-like [Tribolium castaneum] -- -- -- -- -- K01185 E3.2.1.17 lysozyme http://www.genome.jp/dbget-bin/www_bget?ko:K01185 P48816 297 1.5e-25 Lysozyme OS=Bombyx mori PE=1 SV=1 PF01874//PF00646 ATP:dephospho-CoA triphosphoribosyl transferase//F-box domain GO:0016310 phosphorylation GO:0046917//GO:0005515//GO:0005524 triphosphoribosyl-dephospho-CoA synthase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.33635 BP_3 380.69 18.29 1295 91083379 XP_967173.1 375 2.8e-33 PREDICTED: heat shock factor-binding protein 1 [Tribolium castaneum]>gi|270007782|gb|EFA04230.1| hypothetical protein TcasGA2_TC014481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDI2 225 2.8e-17 Heat shock factor-binding protein 1 OS=Pongo abelii GN=HSBP1 PE=3 SV=1 PF02865//PF04513//PF00103//PF06152//PF05478//PF06008 STAT protein, protein interaction domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Somatotropin hormone family//Phage minor capsid protein 2//Prominin//Laminin Domain I GO:0030334//GO:0007165//GO:0045995//GO:0030155//GO:0006355 regulation of cell migration//signal transduction//regulation of embryonic development//regulation of cell adhesion//regulation of transcription, DNA-templated GO:0005198//GO:0005179//GO:0003700//GO:0005102//GO:0004871 structural molecule activity//hormone activity//transcription factor activity, sequence-specific DNA binding//receptor binding//signal transducer activity GO:0019031//GO:0005667//GO:0016021//GO:0019028//GO:0005576 viral envelope//transcription factor complex//integral component of membrane//viral capsid//extracellular region KOG4117 Heat shock factor binding protein Cluster-8309.33636 BP_3 51.19 0.57 4586 546678917 ERL89455.1 261 1.6e-19 hypothetical protein D910_06822 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 138 1.2e-06 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF03604//PF08996//PF00111//PF13465//PF16622//PF01363//PF13912 Zinc finger, C2H2 type//DNA directed RNA polymerase, 7 kDa subunit//DNA Polymerase alpha zinc finger//2Fe-2S iron-sulfur cluster binding domain//Zinc-finger double domain//zinc-finger C2H2-type//FYVE zinc finger//C2H2-type zinc finger GO:0006206//GO:0006260//GO:0006118//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//DNA replication//obsolete electron transport//transcription, DNA-templated//purine nucleobase metabolic process GO:0009055//GO:0051536//GO:0046872//GO:0001882//GO:0003677//GO:0003899//GO:0003887 electron carrier activity//iron-sulfur cluster binding//metal ion binding//nucleoside binding//DNA binding//DNA-directed RNA polymerase activity//DNA-directed DNA polymerase activity GO:0005730//GO:0042575 nucleolus//DNA polymerase complex -- -- Cluster-8309.33637 BP_3 2545.63 30.14 4362 642921956 XP_008192959.1 3973 0.0e+00 PREDICTED: coatomer subunit beta' [Tribolium castaneum]>gi|270007308|gb|EFA03756.1| hypothetical protein TcasGA2_TC013867 [Tribolium castaneum] 820849966 XM_003694119.2 415 0 PREDICTED: Apis florea coatomer subunit beta' (LOC100872730), mRNA K17302 COPB2, SEC27 coatomer, subunit beta' http://www.genome.jp/dbget-bin/www_bget?ko:K17302 O62621 3297 0.0e+00 Coatomer subunit beta' OS=Drosophila melanogaster GN=beta'Cop PE=2 SV=2 PF13181//PF00400//PF04053 Tetratricopeptide repeat//WD domain, G-beta repeat//Coatomer WD associated region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0276 Vesicle coat complex COPI, beta' subunit Cluster-8309.33638 BP_3 562.28 2.14 12956 270007509 EFA03957.1 1887 1.3e-207 hypothetical protein TcasGA2_TC014101 [Tribolium castaneum] 332374221 BT127290.1 481 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 733 3.5e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF01607//PF00642//PF02198//PF01522//PF03176 Chitin binding Peritrophin-A domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Sterile alpha motif (SAM)/Pointed domain//Polysaccharide deacetylase//MMPL family GO:0006030//GO:0005975//GO:0006807 chitin metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0043565//GO:0046872//GO:0008061//GO:0016810 sequence-specific DNA binding//metal ion binding//chitin binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0005634//GO:0016020//GO:0005576 nucleus//membrane//extracellular region -- -- Cluster-8309.33639 BP_3 131.89 0.63 10445 642927132 XP_008195151.1 2005 2.2e-221 PREDICTED: far upstream element-binding protein 1 isoform X2 [Tribolium castaneum] 755783784 XM_006939555.2 43 5.95302e-10 PREDICTED: Felis catus far upstream element (FUSE) binding protein 3 (FUBP3), transcript variant X2, mRNA K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 2.6e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF00013//PF13014//PF13184//PF10192//PF07650 KH domain//KH domain//NusA-like KH domain//Rhodopsin-like GPCR transmembrane domain//KH domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.33642 BP_3 164.21 3.59 2495 642921890 XP_008192932.1 1662 3.1e-182 PREDICTED: cardioacceleratory peptide receptor 2 isoform X1 [Tribolium castaneum]>gi|296396897|gb|ADH10240.1| CCAP receptor 2 [Tribolium castaneum] -- -- -- -- -- K08376 NPSR1, GPR154 neuropeptide S receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08376 Q868T3 1047 2.6e-112 Cardioacceleratory peptide receptor OS=Drosophila melanogaster GN=CCAP-R PE=2 SV=3 PF02118//PF00001 Srg family chemoreceptor//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0007165//GO:0007606 G-protein coupled receptor signaling pathway//signal transduction//sensory perception of chemical stimulus GO:0004888//GO:0004930 transmembrane signaling receptor activity//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.33644 BP_3 44.28 0.49 4644 642923524 XP_008193545.1 3325 0.0e+00 PREDICTED: anoctamin-5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q32M45 1455 2.4e-159 Anoctamin-4 OS=Homo sapiens GN=ANO4 PE=2 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- KOG2514 Uncharacterized conserved protein Cluster-8309.33645 BP_3 1898.44 69.41 1610 91083251 XP_974045.1 485 6.0e-46 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 780659103 XM_011694063.1 107 2.38517e-46 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 436 1.2e-41 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF00270//PF02776 DEAD/DEAH box helicase//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain -- -- GO:0003676//GO:0005524//GO:0030976//GO:0008026 nucleic acid binding//ATP binding//thiamine pyrophosphate binding//ATP-dependent helicase activity -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.33646 BP_3 1832.98 54.93 1900 91083251 XP_974045.1 697 1.9e-70 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 442626186 NM_001273171.1 169 9.66735e-81 Drosophila melanogaster helicase at 25E (Hel25E), transcript variant D, mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q63413 618 1.1e-62 Spliceosome RNA helicase Ddx39b OS=Rattus norvegicus GN=Ddx39b PE=2 SV=3 PF00270//PF00765//PF00128//PF02391//PF04851 DEAD/DEAH box helicase//Autoinducer synthase//Alpha amylase, catalytic domain//MoaE protein//Type III restriction enzyme, res subunit GO:0006777//GO:0005975 Mo-molybdopterin cofactor biosynthetic process//carbohydrate metabolic process GO:0005524//GO:0003824//GO:0016740//GO:0016787//GO:0003677//GO:0008026//GO:0003676//GO:0043169 ATP binding//catalytic activity//transferase activity//hydrolase activity//DNA binding//ATP-dependent helicase activity//nucleic acid binding//cation binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.33647 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02262 CBL proto-oncogene N-terminal domain 1 GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0004871 signal transducer activity GO:0005634 nucleus -- -- Cluster-8309.33650 BP_3 22.64 0.66 1955 264667463 ACY71317.1 234 9.3e-17 ribosomal protein L22 [Chrysomela tremula] 751203339 XM_011176882.1 46 2.36185e-12 PREDICTED: Solenopsis invicta 60S ribosomal protein L22-like (LOC105207442), mRNA -- -- -- -- P50887 131 3.4e-06 60S ribosomal protein L22 OS=Drosophila melanogaster GN=RpL22 PE=1 SV=2 PF01776 Ribosomal L22e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.33651 BP_3 951.94 5.23 9071 642930846 XP_008196111.1 677 1.9e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33653 BP_3 98.16 4.61 1317 642937410 XP_008198824.1 862 9.5e-90 PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|642937412|ref|XP_008198826.1| PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|270000810|gb|EEZ97257.1| hypothetical protein TcasGA2_TC011057 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 380 3.0e-35 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0008152//GO:0008654//GO:0046486//GO:0042967 metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.33654 BP_3 1492.08 35.35 2326 91089723 XP_975024.1 1451 8.4e-158 PREDICTED: ATPase family AAA domain-containing protein 1-B [Tribolium castaneum]>gi|270011311|gb|EFA07759.1| hypothetical protein TcasGA2_TC005313 [Tribolium castaneum] 768421023 XM_011553001.1 182 7.04683e-88 PREDICTED: Plutella xylostella ATPase family AAA domain-containing protein 1-A (LOC105383005), mRNA -- -- -- -- Q503W7 1051 8.4e-113 ATPase family AAA domain-containing protein 1-B OS=Danio rerio GN=atad1b PE=2 SV=2 PF02562//PF02367//PF06414//PF00910//PF05496//PF00158//PF06068//PF01695//PF07728//PF07724//PF00004 PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//RNA helicase//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0002949//GO:0006310//GO:0006355//GO:0006281 tRNA threonylcarbamoyladenosine modification//DNA recombination//regulation of transcription, DNA-templated//DNA repair GO:0009378//GO:0017111//GO:0003724//GO:0003678//GO:0003723//GO:0016301//GO:0016887//GO:0008134//GO:0005524 four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity//DNA helicase activity//RNA binding//kinase activity//ATPase activity//transcription factor binding//ATP binding GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0737 AAA+-type ATPase Cluster-8309.33655 BP_3 2096.06 41.59 2721 349584988 BAL03254.1 1164 1.9e-124 93 kDa serpin [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q5JJ64 501 5.9e-49 Uncharacterized serpin-like protein TK1782 OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=TK1782 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.33656 BP_3 1437.19 20.18 3725 270014262 EFA10710.1 1560 3.1e-170 domino [Tribolium castaneum] 760445496 XM_011401515.1 99 1.56382e-41 Auxenochlorella protothecoides Helicase swr1 partial mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 667 4.5e-68 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF07088//PF01637//PF03796//PF00176//PF05625//PF00154//PF00004 GvpD gas vesicle protein//Archaeal ATPase//DnaB-like helicase C terminal domain//SNF2 family N-terminal domain//PAXNEB protein//recA bacterial DNA recombination protein//ATPase family associated with various cellular activities (AAA) GO:0006281//GO:0006260//GO:0009432 DNA repair//DNA replication//SOS response GO:0005524//GO:0003678//GO:0003697 ATP binding//DNA helicase activity//single-stranded DNA binding GO:0005657//GO:0033588 replication fork//Elongator holoenzyme complex KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.33658 BP_3 3.00 0.31 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.33660 BP_3 10.00 5.67 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33661 BP_3 25.17 0.94 1589 546680707 ERL90933.1 674 7.2e-68 hypothetical protein D910_08275 [Dendroctonus ponderosae] 27616447 BX043166.1 94 3.96597e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC15CD01 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K03521 fixA, etfB electron transfer flavoprotein beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03521 Q9DCW4 573 1.5e-57 Electron transfer flavoprotein subunit beta OS=Mus musculus GN=Etfb PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3180 Electron transfer flavoprotein, beta subunit Cluster-8309.33662 BP_3 405.47 5.82 3649 225543455 NP_001139378.1 1092 5.6e-116 daughters against dpp [Tribolium castaneum] -- -- -- -- -- K04677 SMAD6_7 mothers against decapentaplegic homolog 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04677 O43541 570 7.8e-57 Mothers against decapentaplegic homolog 6 OS=Homo sapiens GN=SMAD6 PE=1 SV=2 PF03165//PF04795//PF03166 MH1 domain//PAPA-1-like conserved region//MH2 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0031011//GO:0005622 Ino80 complex//intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.33665 BP_3 406.50 4.21 4942 642931127 XP_008201673.1 1322 1.6e-142 PREDICTED: uncharacterized protein LOC655872 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02734 DAK2 domain GO:0046486//GO:0006071 glycerolipid metabolic process//glycerol metabolic process GO:0004371 glycerone kinase activity -- -- -- -- Cluster-8309.33666 BP_3 1091.91 11.11 5028 642919614 XP_008191940.1 948 3.9e-99 PREDICTED: serine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K14821 BUD20 bud site selection protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K14821 Q9W3Y0 403 2.5e-37 Zinc finger protein 593 homolog OS=Drosophila melanogaster GN=CG3224 PE=2 SV=1 PF00587//PF17122 tRNA synthetase class II core domain (G, H, P, S and T)//Zinc-finger GO:0006418 tRNA aminoacylation for protein translation GO:0005515//GO:0004812//GO:0008270//GO:0005524//GO:0000166 protein binding//aminoacyl-tRNA ligase activity//zinc ion binding//ATP binding//nucleotide binding -- -- KOG3408 U1-like Zn-finger-containing protein, probabl erole in RNA processing/splicing Cluster-8309.33669 BP_3 28.23 1.22 1408 478258160 ENN78298.1 1097 5.7e-117 hypothetical protein YQE_05448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZV5 799 8.4e-84 Cysteine and histidine-rich protein 1 homolog OS=Drosophila melanogaster GN=CG32486 PE=2 SV=2 PF00097//PF03145//PF02176 Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//TRAF-type zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.33670 BP_3 216.25 29.42 646 167444204 ABZ80663.1 385 9.5e-35 hypothetical antimicrobial peptide [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.33671 BP_3 4.00 1.87 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33672 BP_3 1525.00 15.88 4920 91087491 XP_968373.1 1415 2.7e-153 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] 462366872 APGK01027093.1 51 9.97945e-15 Dendroctonus ponderosae Seq01027103, whole genome shotgun sequence K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 P42765 1078 1.3e-115 3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens GN=ACAA2 PE=1 SV=2 PF05699//PF02803//PF00108 hAT family C-terminal dimerisation region//Thiolase, C-terminal domain//Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747//GO:0046983 transferase activity, transferring acyl groups other than amino-acyl groups//protein dimerization activity -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.33673 BP_3 55.62 0.70 4095 91078908 XP_967303.1 587 2.3e-57 PREDICTED: U1 small nuclear ribonucleoprotein 70 kDa [Tribolium castaneum]>gi|270003669|gb|EFA00117.1| hypothetical protein TcasGA2_TC002933 [Tribolium castaneum] 766937927 XM_011503139.1 111 3.67226e-48 PREDICTED: Ceratosolen solmsi marchali U1 small nuclear ribonucleoprotein 70 kDa-like (LOC105365059), mRNA K11093 SNRP70 U1 small nuclear ribonucleoprotein 70kDa http://www.genome.jp/dbget-bin/www_bget?ko:K11093 P17133 503 5.2e-49 U1 small nuclear ribonucleoprotein 70 kDa OS=Drosophila melanogaster GN=snRNP-U1-70K PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:1901363//GO:0003676//GO:0097159 heterocyclic compound binding//nucleic acid binding//organic cyclic compound binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.33674 BP_3 62.16 1.43 2380 641651338 XP_003241056.2 1368 3.6e-148 PREDICTED: uncharacterized protein LOC100574409 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.33675 BP_3 2612.68 104.83 1493 332376979 AEE63629.1 1831 4.7e-202 unknown [Dendroctonus ponderosae]>gi|478249843|gb|ENN70350.1| hypothetical protein YQE_12858, partial [Dendroctonus ponderosae]>gi|546674164|gb|ERL85616.1| hypothetical protein D910_03035 [Dendroctonus ponderosae] 158296763 XM_317113.3 386 0 Anopheles gambiae str. PEST AGAP008345-PA (AgaP_AGAP008345) mRNA, complete cds K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q3ZC89 1528 2.6e-168 Methionine aminopeptidase 2 OS=Bos taurus GN=METAP2 PE=2 SV=1 PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- KOG2775 Metallopeptidase Cluster-8309.33676 BP_3 913.38 36.59 1495 478250728 ENN71220.1 832 3.2e-86 hypothetical protein YQE_12148, partial [Dendroctonus ponderosae]>gi|546678591|gb|ERL89173.1| hypothetical protein D910_06548 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4LFQ9 737 1.4e-76 Protein alan shepard OS=Drosophila virilis GN=shep PE=3 SV=2 PF09726//PF00076 Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG4733 FOG: RRM domain Cluster-8309.33678 BP_3 36.06 0.40 4653 642938616 XP_008199867.1 1598 1.5e-174 PREDICTED: epidermal growth factor receptor kinase substrate 8 [Tribolium castaneum] -- -- -- -- -- K17277 EPS8 epidermal growth factor receptor kinase substrate 8 http://www.genome.jp/dbget-bin/www_bget?ko:K17277 Q12929 465 1.5e-44 Epidermal growth factor receptor kinase substrate 8 OS=Homo sapiens GN=EPS8 PE=1 SV=1 PF08416//PF00536//PF02198//PF00018//PF14604 Phosphotyrosine-binding domain//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain//SH3 domain//Variant SH3 domain -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus KOG3557 Epidermal growth factor receptor kinase substrate Cluster-8309.33679 BP_3 15.64 0.70 1367 642930375 XP_008196372.1 535 8.2e-52 PREDICTED: myosin-2 essential light chain isoform X1 [Tribolium castaneum] 389608774 AK401377.1 81 5.7288e-32 Papilio xuthus mRNA for myosin light chain cytoplasmic, complete cds, sequence id: Px-0488 K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 P54357 465 4.4e-45 Myosin-2 essential light chain OS=Drosophila melanogaster GN=Mlc-c PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.33680 BP_3 653.56 4.59 7148 332375668 AEE62975.1 2213 1.1e-245 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03544 clpX, CLPX ATP-dependent Clp protease ATP-binding subunit ClpX http://www.genome.jp/dbget-bin/www_bget?ko:K03544 Q5U2U0 1522 6.2e-167 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Rattus norvegicus GN=Clpx PE=2 SV=1 PF07724//PF00437//PF00004//PF00158//PF06068//PF01057//PF05496//PF07728//PF01695//PF14532//PF10662//PF00270//PF02367//PF02562//PF00005 AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Ethanolamine utilisation - propanediol utilisation//DEAD/DEAH box helicase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ABC transporter GO:0006576//GO:0006310//GO:0002949//GO:0019079//GO:0006281//GO:0006810//GO:0006355 cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification//viral genome replication//DNA repair//transport//regulation of transcription, DNA-templated GO:0003678//GO:0003676//GO:0009378//GO:0005524//GO:0008134//GO:0016887 DNA helicase activity//nucleic acid binding//four-way junction helicase activity//ATP binding//transcription factor binding//ATPase activity GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0745 Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) Cluster-8309.33681 BP_3 283.04 2.63 5471 642934848 XP_008197836.1 2731 7.5e-306 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.67958e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA K10423 CLIP3_4 CAP-Gly domain-containing linker protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10423 Q5JR59 254 5.2e-20 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33682 BP_3 57.00 1.25 2488 332374040 AEE62161.1 1406 1.5e-152 unknown [Dendroctonus ponderosae]>gi|478259932|gb|ENN79734.1| hypothetical protein YQE_03790, partial [Dendroctonus ponderosae]>gi|546674727|gb|ERL86036.1| hypothetical protein D910_03450 [Dendroctonus ponderosae] -- -- -- -- -- K00965 galT, GALT UDPglucose--hexose-1-phosphate uridylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00965 Q9VMA2 1039 2.2e-111 Probable galactose-1-phosphate uridylyltransferase OS=Drosophila melanogaster GN=Galt PE=2 SV=2 PF01087//PF02744//PF07074 Galactose-1-phosphate uridyl transferase, N-terminal domain//Galactose-1-phosphate uridyl transferase, C-terminal domain//Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0006012//GO:0006613//GO:0009117 galactose metabolic process//cotranslational protein targeting to membrane//nucleotide metabolic process GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex KOG2958 Galactose-1-phosphate uridylyltransferase Cluster-8309.33683 BP_3 4350.00 56.99 3971 91086963 XP_973116.1 884 8.1e-92 PREDICTED: protein SOX-15-like isoform X1 [Tribolium castaneum] 642929295 XM_008197554.1 135 1.62156e-61 PREDICTED: Tribolium castaneum protein SOX-15-like (LOC661892), transcript variant X2, mRNA K09268 SOX4_11_12 transcription factor SOX4/11/12 (SOX group C) http://www.genome.jp/dbget-bin/www_bget?ko:K09268 P40656 411 2.3e-38 Putative transcription factor SOX-14 OS=Drosophila melanogaster GN=Sox14 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.33684 BP_3 892.55 11.65 3984 478257987 ENN78125.1 2376 8.0e-265 hypothetical protein YQE_05279, partial [Dendroctonus ponderosae] 198451987 XM_001358537.2 567 0 Drosophila pseudoobscura pseudoobscura GA21805 (Dpse\GA21805), partial mRNA K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q86XK2 2044 1.0e-227 F-box only protein 11 OS=Homo sapiens GN=FBXO11 PE=1 SV=3 PF07839//PF02207//PF03284 Plant calmodulin-binding domain//Putative zinc finger in N-recognin (UBR box)//Phenazine biosynthesis protein A/B GO:0017000 antibiotic biosynthetic process GO:0008270//GO:0005516 zinc ion binding//calmodulin binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.33685 BP_3 761.00 17.67 2367 91089295 XP_971418.1 1381 1.1e-149 PREDICTED: membrane-bound alkaline phosphatase [Tribolium castaneum]>gi|270012503|gb|EFA08951.1| hypothetical protein TcasGA2_TC006658 [Tribolium castaneum] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 1073 2.4e-115 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF00245//PF01663//PF01676 Alkaline phosphatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Metalloenzyme superfamily GO:0008152 metabolic process GO:0016787//GO:0003824//GO:0016791//GO:0046872 hydrolase activity//catalytic activity//phosphatase activity//metal ion binding -- -- -- -- Cluster-8309.33687 BP_3 24.62 0.53 2541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33691 BP_3 390.68 4.23 4748 642915350 XP_008190583.1 277 2.3e-21 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q86MW9 234 9.3e-18 E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni GN=SINA PE=1 SV=1 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.33692 BP_3 167.65 1.31 6448 91089955 XP_973514.1 1912 8.2e-211 PREDICTED: nucleolar protein 56 [Tribolium castaneum]>gi|270013678|gb|EFA10126.1| hypothetical protein TcasGA2_TC012306 [Tribolium castaneum] -- -- -- -- -- K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q3SZ63 1499 2.6e-164 Nucleolar protein 56 OS=Bos taurus GN=NOP56 PE=2 SV=1 PF05557//PF02376 Mitotic checkpoint protein//CUT domain GO:0007094 mitotic spindle assembly checkpoint GO:0003677 DNA binding -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-8309.33693 BP_3 3100.32 30.43 5203 91089955 XP_973514.1 1912 6.6e-211 PREDICTED: nucleolar protein 56 [Tribolium castaneum]>gi|270013678|gb|EFA10126.1| hypothetical protein TcasGA2_TC012306 [Tribolium castaneum] 642933836 XM_008199307.1 189 2.04076e-91 PREDICTED: Tribolium castaneum epsin-like protein (LOC662353), transcript variant X1, mRNA K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q3SZ63 1499 2.1e-164 Nucleolar protein 56 OS=Bos taurus GN=NOP56 PE=2 SV=1 PF07651 ANTH domain -- -- GO:0005543 phospholipid binding -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-8309.33695 BP_3 4220.05 112.55 2099 642930890 XP_008196128.1 375 4.5e-33 PREDICTED: protein-methionine sulfoxide oxidase MICAL3 isoform X8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 208 4.3e-15 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33696 BP_3 285.72 2.79 5225 478262788 ENN81305.1 4123 0.0e+00 hypothetical protein YQE_02273, partial [Dendroctonus ponderosae]>gi|546672906|gb|ERL84622.1| hypothetical protein D910_02050 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2V2M9 1512 6.6e-166 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF06371 Diaphanous GTPase-binding Domain GO:0030036 actin cytoskeleton organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.33697 BP_3 1363.30 18.15 3913 91089461 XP_968383.1 1941 2.2e-214 PREDICTED: fatty-acid amide hydrolase 2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6GMR7 1103 1.3e-118 Fatty-acid amide hydrolase 2 OS=Homo sapiens GN=FAAH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.33699 BP_3 304.59 14.65 1294 270010524 EFA06972.1 1424 6.3e-155 hypothetical protein TcasGA2_TC009932 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI7 662 6.0e-68 Upstream-binding protein 1 OS=Homo sapiens GN=UBP1 PE=1 SV=1 PF00918 Gastrin/cholecystokinin family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region KOG4091 Transcription factor Cluster-8309.337 BP_3 3.00 1.34 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33701 BP_3 977.39 25.88 2112 478251082 ENN71558.1 894 3.0e-93 hypothetical protein YQE_11660, partial [Dendroctonus ponderosae]>gi|546671909|gb|ERL84016.1| hypothetical protein D910_01335 [Dendroctonus ponderosae]>gi|546671968|gb|ERL84050.1| hypothetical protein D910_01379 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P04572 289 1.7e-24 Sarcoplasmic calcium-binding protein OS=Perinereis vancaurica tetradentata PE=1 SV=1 PF13202//PF00036//PF08119//PF10591//PF13833//PF13405//PF05983//PF13499 EF hand//EF hand//Scorpion acidic alpha-KTx toxin family//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//MED7 protein//EF-hand domain pair GO:0006357//GO:0009405//GO:0007165//GO:0006810 regulation of transcription from RNA polymerase II promoter//pathogenesis//signal transduction//transport GO:0005509//GO:0001104//GO:0019870 calcium ion binding//RNA polymerase II transcription cofactor activity//potassium channel inhibitor activity GO:0005576//GO:0005578//GO:0016592 extracellular region//proteinaceous extracellular matrix//mediator complex -- -- Cluster-8309.33704 BP_3 485.64 6.79 3738 478262788 ENN81305.1 4017 0.0e+00 hypothetical protein YQE_02273, partial [Dendroctonus ponderosae]>gi|546672906|gb|ERL84622.1| hypothetical protein D910_02050 [Dendroctonus ponderosae] 642918459 XM_008193262.1 377 0 PREDICTED: Tribolium castaneum FH1/FH2 domain-containing protein 3 (LOC659452), transcript variant X5, mRNA -- -- -- -- Q2V2M9 1472 2.0e-161 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF06371//PF01059 Diaphanous GTPase-binding Domain//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0055114//GO:0030036//GO:0006120 oxidation-reduction process//actin cytoskeleton organization//mitochondrial electron transport, NADH to ubiquinone GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.33706 BP_3 448.25 4.86 4736 642918460 XP_008191484.1 4422 0.0e+00 PREDICTED: FH1/FH2 domain-containing protein 3 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2V2M9 1472 2.6e-161 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF06371//PF01059 Diaphanous GTPase-binding Domain//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006120//GO:0030036//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//actin cytoskeleton organization//oxidation-reduction process GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.33707 BP_3 444.72 5.22 4396 607367304 EZA61451.1 490 4.3e-46 Serine/arginine-rich splicing factor, partial [Cerapachys biroi] 195401199 XM_002059166.1 102 3.97259e-43 Drosophila virilis GJ16161 (Dvir\GJ16161), mRNA K12891 SFRS2 splicing factor, arginine/serine-rich 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12891 Q06A98 418 4.0e-39 Serine/arginine-rich splicing factor 2 OS=Sus scrofa GN=SRSF2 PE=2 SV=1 PF03106//PF04805//PF00042//PF00076//PF05001 WRKY DNA -binding domain//E10-like protein conserved region//Globin//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA polymerase Rpb1 C-terminal repeat GO:0006366//GO:0055114//GO:0006355 transcription from RNA polymerase II promoter//oxidation-reduction process//regulation of transcription, DNA-templated GO:0019825//GO:0003677//GO:0003700//GO:0020037//GO:0016972//GO:0043565//GO:0003676 oxygen binding//DNA binding//transcription factor activity, sequence-specific DNA binding//heme binding//thiol oxidase activity//sequence-specific DNA binding//nucleic acid binding GO:0005667//GO:0005665 transcription factor complex//DNA-directed RNA polymerase II, core complex KOG4207 Predicted splicing factor, SR protein superfamily Cluster-8309.33709 BP_3 6.00 0.33 1176 119628207 EAX07802.1 464 1.2e-43 high-mobility group nucleosomal binding domain 2, isoform CRA_a [Homo sapiens]>gi|119628210|gb|EAX07805.1| high-mobility group nucleosomal binding domain 2, isoform CRA_a [Homo sapiens] 45708368 BC003050.1 1171 0 Homo sapiens high-mobility group nucleosomal binding domain 2, mRNA (cDNA clone MGC:750 IMAGE:3543809), complete cds K11300 HMGN2 high-mobility group nucleosome-binding domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11300 Q86SG4 363 2.5e-33 Putative Dresden prostate carcinoma protein 2 OS=Homo sapiens GN=HMGN2P46 PE=5 SV=1 PF01101//PF03600 HMG14 and HMG17//Citrate transporter GO:0055085 transmembrane transport GO:0031492 nucleosomal DNA binding GO:0000785//GO:0005634//GO:0016021 chromatin//nucleus//integral component of membrane -- -- Cluster-8309.33710 BP_3 10.00 0.97 791 831575288 XP_012736362.1 690 5.0e-70 PREDICTED: elongation factor 2-like [Fundulus heteroclitus] 697069898 XM_009651838.1 782 0 Verticillium dahliae VdLs.17 elongation factor 2 mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q96X45 877 4.3e-93 Elongation factor 2 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cot-3 PE=3 SV=3 PF03764 Elongation factor G, domain IV -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8309.33711 BP_3 9.00 0.81 829 470237334 XP_004350624.1 1032 1.2e-109 elongation factor 2 [Dictyostelium fasciculatum]>gi|328865530|gb|EGG13916.1| elongation factor 2 [Dictyostelium fasciculatum] 768311753 CP010981.1 814 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q96X45 1285 2.2e-140 Elongation factor 2 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cot-3 PE=3 SV=3 PF03144//PF03764 Elongation factor Tu domain 2//Elongation factor G, domain IV GO:0006414//GO:0006184//GO:0006448 translational elongation//obsolete GTP catabolic process//regulation of translational elongation GO:0005525//GO:0003746//GO:0003924 GTP binding//translation elongation factor activity//GTPase activity GO:0005840 ribosome KOG0469 Elongation factor 2 Cluster-8309.33712 BP_3 363.51 4.71 4010 642928023 XP_008200123.1 3052 0.0e+00 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X1 [Tribolium castaneum]>gi|270010887|gb|EFA07335.1| hypothetical protein TcasGA2_TC015931 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.78438e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q60902 1273 2.6e-138 Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus GN=Eps15l1 PE=1 SV=3 PF10186//PF12763//PF13833//PF13405//PF13499//PF00750//PF13202//PF00036 Vacuolar sorting 38 and autophagy-related subunit 14//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//tRNA synthetases class I (R)//EF hand//EF hand GO:0006525//GO:0006560//GO:0006420//GO:0010508 arginine metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//positive regulation of autophagy GO:0005524//GO:0005515//GO:0004814//GO:0005509 ATP binding//protein binding//arginine-tRNA ligase activity//calcium ion binding -- -- KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.33714 BP_3 3880.81 146.56 1568 642936658 XP_973680.2 469 4.2e-44 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC662495 [Tribolium castaneum] -- -- -- -- -- K09027 XBP1 X box-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09027 Q3SZZ2 213 8.4e-16 X-box-binding protein 1 OS=Bos taurus GN=XBP1 PE=2 SV=1 PF06005//PF01496//PF00170//PF04632//PF06156//PF07716//PF12767//PF02601//PF03131 Protein of unknown function (DUF904)//V-type ATPase 116kDa subunit family//bZIP transcription factor//Fusaric acid resistance protein family//Protein of unknown function (DUF972)//Basic region leucine zipper//Transcriptional regulator of RNA polII, SAGA, subunit//Exonuclease VII, large subunit//bZIP Maf transcription factor GO:0006810//GO:0006260//GO:0006355//GO:0015992//GO:0015991//GO:0000917//GO:0043093//GO:0006308 transport//DNA replication//regulation of transcription, DNA-templated//proton transport//ATP hydrolysis coupled proton transport//barrier septum assembly//FtsZ-dependent cytokinesis//DNA catabolic process GO:0015078//GO:0043565//GO:0003700//GO:0003677//GO:0008855 hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//exodeoxyribonuclease VII activity GO:0009318//GO:0005737//GO:0005886//GO:0005634//GO:0070461//GO:0005667//GO:0033179 exodeoxyribonuclease VII complex//cytoplasm//plasma membrane//nucleus//SAGA-type complex//transcription factor complex//proton-transporting V-type ATPase, V0 domain KOG4005 Transcription factor XBP-1 Cluster-8309.33715 BP_3 21.61 0.49 2438 642916256 XP_008190949.1 1280 6.0e-138 PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum]>gi|642916258|ref|XP_008190950.1| PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.6e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.33716 BP_3 2132.40 28.25 3930 642918803 XP_008191592.1 1891 1.4e-208 PREDICTED: mitochondrial import receptor subunit TOM70 [Tribolium castaneum]>gi|270005628|gb|EFA02076.1| hypothetical protein TcasGA2_TC007711 [Tribolium castaneum] -- -- -- -- -- K17768 TOM70 mitochondrial import receptor subunit TOM70 http://www.genome.jp/dbget-bin/www_bget?ko:K17768 Q75Q39 1167 5.0e-126 Mitochondrial import receptor subunit TOM70 OS=Rattus norvegicus GN=Tomm70a PE=1 SV=1 PF13181//PF13371//PF13374//PF00515//PF13414//PF06888//PF13176//PF05822 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Putative Phosphatase//Tetratricopeptide repeat//Pyrimidine 5'-nucleotidase (UMPH-1) GO:0008152 metabolic process GO:0008253//GO:0016791//GO:0005515//GO:0000287 5'-nucleotidase activity//phosphatase activity//protein binding//magnesium ion binding GO:0005737 cytoplasm KOG1615 Phosphoserine phosphatase Cluster-8309.33718 BP_3 228.00 4.88 2543 478260826 ENN80478.1 2360 3.6e-263 hypothetical protein YQE_03083, partial [Dendroctonus ponderosae]>gi|546672566|gb|ERL84378.1| hypothetical protein D910_01808 [Dendroctonus ponderosae]>gi|546672569|gb|ERL84379.1| hypothetical protein D910_01809 [Dendroctonus ponderosae]>gi|546672573|gb|ERL84382.1| hypothetical protein D910_01812 [Dendroctonus ponderosae] -- -- -- -- -- K05034 SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA) member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05034 P31648 1300 1.2e-141 Sodium- and chloride-dependent GABA transporter 1 OS=Mus musculus GN=Slc6a1 PE=1 SV=2 PF00209//PF06955//PF06596 Sodium:neurotransmitter symporter family//Xyloglucan endo-transglycosylase (XET) C-terminus//Photosystem II reaction centre X protein (PsbX) GO:0006073//GO:0006812//GO:0006836//GO:0015979 cellular glucan metabolic process//cation transport//neurotransmitter transport//photosynthesis GO:0016762//GO:0005328 xyloglucan:xyloglucosyl transferase activity//neurotransmitter:sodium symporter activity GO:0016020//GO:0009523//GO:0016021//GO:0005618//GO:0048046 membrane//photosystem II//integral component of membrane//cell wall//apoplast -- -- Cluster-8309.33722 BP_3 123.64 1.82 3572 91089929 XP_973045.1 210 1.0e-13 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08114//PF15168//PF02935 ATPase proteolipid family//Triple QxxK/R motif-containing protein family//Cytochrome c oxidase subunit VIIc GO:0006123//GO:0050790//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//regulation of catalytic activity//proton transport GO:0030234//GO:0004129 enzyme regulator activity//cytochrome-c oxidase activity GO:0005789//GO:0045277 endoplasmic reticulum membrane//respiratory chain complex IV -- -- Cluster-8309.33723 BP_3 21.56 0.87 1483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.33724 BP_3 315.00 19.33 1077 91083189 XP_972753.1 649 3.9e-65 PREDICTED: protein CWC15 homolog [Tribolium castaneum]>gi|270006973|gb|EFA03421.1| hypothetical protein TcasGA2_TC013408 [Tribolium castaneum] 617435114 XM_007563115.1 44 1.66022e-11 PREDICTED: Poecilia formosa CWC15 spliceosome-associated protein homolog (S. cerevisiae) (cwc15), mRNA K12863 CWC15 protein CWC15 http://www.genome.jp/dbget-bin/www_bget?ko:K12863 Q5RE65 416 1.7e-39 Spliceosome-associated protein CWC15 homolog OS=Pongo abelii GN=CWC15 PE=2 SV=1 PF04889 Cwf15/Cwc15 cell cycle control protein GO:0000398 mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex KOG3228 Uncharacterized conserved protein Cluster-8309.33725 BP_3 149.01 1.17 6413 642912052 XP_008199072.1 2483 5.0e-277 PREDICTED: nuclear factor 1 B-type isoform X4 [Tribolium castaneum] 58037658 AC152508.3 177 1.17958e-84 Tribolium castaneum BAC T.cast_C29K22 (Clemson University Genomics Institute Tribolium castaneum BAC Library (Red Flour Beetle)) complete sequence K09172 NFIN nuclear factor I, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09172 Q02780 750 1.8e-77 Nuclear factor 1 A-type OS=Mus musculus GN=Nfia PE=1 SV=1 PF03165//PF00859 MH1 domain//CTF/NF-I family transcription modulation region GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005634//GO:0005667 intracellular//nucleus//transcription factor complex KOG3663 Nuclear factor I Cluster-8309.33726 BP_3 81.00 4.36 1188 201023367 NP_001128425.1 678 1.9e-68 R2D2 protein [Tribolium castaneum]>gi|642930022|ref|XP_008196215.1| PREDICTED: R2D2 protein isoform X1 [Tribolium castaneum]>gi|642930024|ref|XP_008196216.1| PREDICTED: R2D2 protein isoform X1 [Tribolium castaneum]>gi|270009455|gb|EFA05903.1| hypothetical protein TcasGA2_TC008716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXR1 226 2.0e-17 RISC-loading complex subunit tarbp2 OS=Danio rerio GN=tarbp2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33727 BP_3 5478.22 179.22 1765 91083463 XP_971028.1 842 2.7e-87 PREDICTED: peptidyl-prolyl cis-trans isomerase B [Tribolium castaneum]>gi|270010823|gb|EFA07271.1| hypothetical protein TcasGA2_TC014505 [Tribolium castaneum] 699705106 XM_009893823.1 91 2.05417e-37 PREDICTED: Charadrius vociferus peptidylprolyl isomerase C (cyclophilin C) (PPIC), mRNA K03768 PPIB, ppiB peptidyl-prolyl cis-trans isomerase B (cyclophilin B) http://www.genome.jp/dbget-bin/www_bget?ko:K03768 P80311 679 8.7e-70 Peptidyl-prolyl cis-trans isomerase B OS=Bos taurus GN=PPIB PE=1 SV=4 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0880 Peptidyl-prolyl cis-trans isomerase Cluster-8309.33728 BP_3 690.58 26.56 1545 157116634 XP_001658586.1 229 2.8e-16 AAEL007679-PA [Aedes aegypti]>gi|108876369|gb|EAT40594.1| AAEL007679-PA [Aedes aegypti] -- -- -- -- -- K17553 PPP1R11 protein phosphatase 1 regulatory subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K17553 Q568K2 176 1.6e-11 Protein phosphatase 1 regulatory subunit 11 OS=Danio rerio GN=ppp1r11 PE=1 SV=1 PF06800 Sugar transport protein GO:0008643//GO:0034219 carbohydrate transport//carbohydrate transmembrane transport GO:0015144 carbohydrate transmembrane transporter activity GO:0016021 integral component of membrane KOG4102 Uncharacterized conserved protein Cluster-8309.33729 BP_3 4.04 0.42 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33730 BP_3 19.77 0.31 3386 642934081 XP_008196456.1 1036 1.6e-109 PREDICTED: phosphatase and actin regulator 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.5e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00344//PF00957 SecY translocase//Synaptobrevin GO:0015031//GO:0016192 protein transport//vesicle-mediated transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.33731 BP_3 9760.33 109.65 4582 642927501 XP_008195294.1 965 3.8e-101 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26, partial [Tribolium castaneum] -- -- -- -- -- K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 -- -- -- -- PF03427 Carbohydrate binding domain (family 19) GO:0006032 chitin catabolic process GO:0008061 chitin binding -- -- -- -- Cluster-8309.33732 BP_3 339.00 13.80 1476 332375018 AEE62650.1 531 2.6e-51 unknown [Dendroctonus ponderosae]>gi|478263507|gb|ENN81860.1| hypothetical protein YQE_01753, partial [Dendroctonus ponderosae]>gi|478263508|gb|ENN81861.1| hypothetical protein YQE_01753, partial [Dendroctonus ponderosae]>gi|546674179|gb|ERL85624.1| hypothetical protein D910_03043 [Dendroctonus ponderosae] -- -- -- -- -- K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q95108 267 4.3e-22 Thioredoxin, mitochondrial OS=Bos taurus GN=TXN2 PE=1 SV=2 PF00122//PF06645//PF00085//PF00578//PF00003//PF07689 E1-E2 ATPase//Microsomal signal peptidase 12 kDa subunit (SPC12)//Thioredoxin//AhpC/TSA family//7 transmembrane sweet-taste receptor of 3 GCPR//KaiB domain GO:0006465//GO:0048511//GO:0045454//GO:0055114//GO:0007186 signal peptide processing//rhythmic process//cell redox homeostasis//oxidation-reduction process//G-protein coupled receptor signaling pathway GO:0016491//GO:0004930//GO:0008233//GO:0046872//GO:0000166//GO:0016209 oxidoreductase activity//G-protein coupled receptor activity//peptidase activity//metal ion binding//nucleotide binding//antioxidant activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex KOG0910 Thioredoxin-like protein Cluster-8309.33737 BP_3 42.10 1.00 2312 642916772 XP_008192547.1 853 1.8e-88 PREDICTED: peptidoglycan-recognition protein LE-like [Tribolium castaneum]>gi|270004832|gb|EFA01280.1| hypothetical protein TcasGA2_TC002790 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9VXN9 410 1.8e-38 Peptidoglycan-recognition protein LE OS=Drosophila melanogaster GN=PGRP-LE PE=1 SV=1 PF05093//PF01510 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//N-acetylmuramoyl-L-alanine amidase GO:0009253//GO:0006807//GO:0009252//GO:0016226 peptidoglycan catabolic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process//iron-sulfur cluster assembly GO:0051536//GO:0008745 iron-sulfur cluster binding//N-acetylmuramoyl-L-alanine amidase activity GO:0005737 cytoplasm -- -- Cluster-8309.33738 BP_3 1150.97 42.37 1601 642931239 XP_971757.2 1136 2.0e-121 PREDICTED: enoyl-CoA hydratase, mitochondrial [Tribolium castaneum] 589950009 XM_006987599.1 62 2.45693e-21 PREDICTED: Peromyscus maniculatus bairdii enoyl CoA hydratase, short chain, 1, mitochondrial (Echs1), mRNA K07511 ECHS1 enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K07511 P34559 892 1.6e-94 Probable enoyl-CoA hydratase, mitochondrial OS=Caenorhabditis elegans GN=ech-6 PE=3 SV=1 PF01343//PF00378//PF16113 Peptidase family S49//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0003824//GO:0016836//GO:0008233 catalytic activity//hydro-lyase activity//peptidase activity -- -- KOG1679 Enoyl-CoA hydratase Cluster-8309.33739 BP_3 60.42 0.46 6631 642925135 XP_008194182.1 2153 9.5e-239 PREDICTED: rho guanine nucleotide exchange factor 7 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q9ES28 559 2.7e-55 Rho guanine nucleotide exchange factor 7 OS=Mus musculus GN=Arhgef7 PE=1 SV=2 PF00018//PF14604//PF00621//PF10280 SH3 domain//Variant SH3 domain//RhoGEF domain//Mediator complex protein GO:0006357//GO:0035023//GO:0043087 regulation of transcription from RNA polymerase II promoter//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515//GO:0001104 Rho guanyl-nucleotide exchange factor activity//protein binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.3374 BP_3 7.00 0.39 1158 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33741 BP_3 59.00 21.22 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33742 BP_3 581.00 23.65 1476 91094707 XP_969750.1 1419 2.7e-154 PREDICTED: geranylgeranyl transferase type-2 subunit beta [Tribolium castaneum]>gi|270016521|gb|EFA12967.1| hypothetical protein TcasGA2_TC001418 [Tribolium castaneum] -- -- -- -- -- K05956 RABGGTB geranylgeranyl transferase type-2 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K05956 P53611 1160 1.2e-125 Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens GN=RABGGTB PE=1 SV=2 PF00432 Prenyltransferase and squalene oxidase repeat GO:0018344 protein geranylgeranylation GO:0003824//GO:0004663 catalytic activity//Rab geranylgeranyltransferase activity GO:0005968 Rab-protein geranylgeranyltransferase complex KOG0366 Protein geranylgeranyltransferase type II, beta subunit Cluster-8309.33743 BP_3 181.12 0.95 9466 91091582 XP_968188.1 2520 3.8e-281 PREDICTED: leucine-rich repeat protein soc-2 homolog [Tribolium castaneum]>gi|270001034|gb|EEZ97481.1| hypothetical protein TcasGA2_TC011315 [Tribolium castaneum] 170032990 XM_001844311.1 225 3.61904e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 8.7e-217 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF13180//PF00412//PF14304//PF10468//PF00560//PF00595//PF13855 PDZ domain//LIM domain//Transcription termination and cleavage factor C-terminal//Carboxypeptidase inhibitor I68//Leucine Rich Repeat//PDZ domain (Also known as DHR or GLGF)//Leucine rich repeat GO:0007596//GO:0031124//GO:0010951 blood coagulation//mRNA 3'-end processing//negative regulation of endopeptidase activity GO:0008191//GO:0008270//GO:0005515 metalloendopeptidase inhibitor activity//zinc ion binding//protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33746 BP_3 167.29 29.94 561 91087535 XP_970133.1 754 1.4e-77 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] 642930219 XM_965040.2 199 5.75e-98 PREDICTED: Tribolium castaneum DNA-directed RNA polymerases I, II, and III subunit RPABC3 (LOC658676), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 559 2.3e-56 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.33747 BP_3 564.50 22.96 1477 642923778 XP_008193880.1 997 2.4e-105 PREDICTED: zinc finger protein 395 isoform X1 [Tribolium castaneum] 462336375 APGK01037911.1 36 6.4252e-07 Dendroctonus ponderosae Seq01037921, whole genome shotgun sequence -- -- -- -- Q6DFC8 154 5.5e-09 Zinc finger protein 395 OS=Xenopus laevis GN=znf395 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33749 BP_3 80.00 11.43 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.33753 BP_3 2251.41 33.21 3559 270003477 EEZ99924.1 1744 1.4e-191 hypothetical protein TcasGA2_TC002717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 947 1.5e-100 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF13417//PF07651 Glutathione S-transferase, N-terminal domain//ANTH domain -- -- GO:0005543//GO:0005515 phospholipid binding//protein binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.33756 BP_3 1908.21 15.31 6301 642917185 XP_966369.3 1730 1.0e-189 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like isoform X2 [Tribolium castaneum] 642919330 XM_008193606.1 90 2.67341e-36 PREDICTED: Tribolium castaneum phosphatidylinositol-binding clathrin assembly protein LAP-like (LOC103312595), mRNA -- -- -- -- Q9VI75 944 5.8e-100 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF07651 ANTH domain -- -- GO:0005543 phospholipid binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.33757 BP_3 390.23 7.30 2867 270016160 EFA12608.1 391 8.5e-35 hypothetical protein TcasGA2_TC006849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33758 BP_3 3380.16 31.54 5458 478253683 ENN73984.1 622 2.7e-61 hypothetical protein YQE_09419, partial [Dendroctonus ponderosae]>gi|478266021|gb|ENN82657.1| hypothetical protein YQE_00972, partial [Dendroctonus ponderosae] 617660876 XM_007537263.1 115 2.93148e-50 PREDICTED: Erinaceus europaeus ZFP36 ring finger protein-like 2 (ZFP36L2), mRNA K18753 ZFP36L butyrate response factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18753 P47980 385 3.3e-35 Protein TIS11 OS=Drosophila melanogaster GN=Tis11 PE=2 SV=2 PF08352//PF00642 Oligopeptide/dipeptide transporter, C-terminal region//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0015833 peptide transport GO:0046872//GO:0000166//GO:0005524 metal ion binding//nucleotide binding//ATP binding -- -- KOG1677 CCCH-type Zn-finger protein Cluster-8309.33759 BP_3 585.00 33.64 1130 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33760 BP_3 93.00 6.43 989 570341954 AHE77375.1 537 3.5e-52 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 247 6.0e-20 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0006413//GO:0007423//GO:0006446 translational initiation//sensory organ development//regulation of translational initiation GO:0003743//GO:0005212 translation initiation factor activity//structural constituent of eye lens GO:0005840 ribosome -- -- Cluster-8309.33761 BP_3 13.50 0.33 2240 478256359 ENN76549.1 2332 5.6e-260 hypothetical protein YQE_07000, partial [Dendroctonus ponderosae]>gi|546680788|gb|ERL90994.1| hypothetical protein D910_08336 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 274 1.0e-22 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33764 BP_3 20.61 1.29 1061 -- -- -- -- -- 462299627 APGK01051253.1 52 5.83817e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33765 BP_3 368.64 5.83 3340 642914391 XP_008201658.1 2481 4.4e-277 PREDICTED: glutamate receptor ionotropic, delta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62640 330 4.8e-29 Glutamate receptor ionotropic, delta-1 OS=Rattus norvegicus GN=Grid1 PE=2 SV=1 PF00060//PF10613//PF07826 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//IMP cyclohydrolase-like protein GO:0006807//GO:0006811//GO:0006144//GO:0006164//GO:0007268//GO:0007165//GO:0006188 nitrogen compound metabolic process//ion transport//purine nucleobase metabolic process//purine nucleotide biosynthetic process//synaptic transmission//signal transduction//IMP biosynthetic process GO:0003937//GO:0005234//GO:0004970 IMP cyclohydrolase activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0042720//GO:0016020 mitochondrial inner membrane peptidase complex//membrane -- -- Cluster-8309.33766 BP_3 639.55 17.43 2060 478250623 ENN71115.1 494 7.0e-47 hypothetical protein YQE_12048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:1903818//GO:0030431//GO:0032222 positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.33767 BP_3 8.00 2.25 463 170321839 BAG14264.1 295 1.9e-24 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P19221 143 3.2e-08 Prothrombin OS=Mus musculus GN=F2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33772 BP_3 777.84 5.62 6965 270011709 EFA08157.1 1968 2.8e-217 hypothetical protein TcasGA2_TC005777 [Tribolium castaneum] 642931878 XM_967548.3 364 0 PREDICTED: Tribolium castaneum casein kinase I isoform delta-A (LOC661388), transcript variant X2, mRNA K08959 CSNK1D casein kinase 1, delta http://www.genome.jp/dbget-bin/www_bget?ko:K08959 Q9DC28 1532 4.2e-168 Casein kinase I isoform delta OS=Mus musculus GN=Csnk1d PE=1 SV=2 PF05445//PF00069//PF07714 Poxvirus serine/threonine protein kinase//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.33776 BP_3 21.08 0.34 3243 642924646 XP_008194378.1 232 2.6e-16 PREDICTED: tensin isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855//PF16686 Leucine rich repeat//ssDNA-binding domain of telomere protection protein -- -- GO:0005515//GO:0043047 protein binding//single-stranded telomeric DNA binding -- -- -- -- Cluster-8309.33778 BP_3 219.45 1.18 9255 189238003 XP_969912.2 3006 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925068|ref|XP_008194156.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925070|ref|XP_008194157.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|270008050|gb|EFA04498.1| hypothetical protein TcasGA2_TC014806 [Tribolium castaneum] 642925074 XM_008195937.1 248 5.79608e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 252 1.5e-19 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF00715//PF05792//PF02196//PF00096//PF13465//PF04988 Interleukin 2//Candida agglutinin-like (ALS)//Raf-like Ras-binding domain//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) GO:0007155//GO:0006955//GO:0008283//GO:0040007//GO:0007165 cell adhesion//immune response//cell proliferation//growth//signal transduction GO:0005134//GO:0046872//GO:0008083//GO:0003677//GO:0005057 interleukin-2 receptor binding//metal ion binding//growth factor activity//DNA binding//receptor signaling protein activity GO:0005893//GO:0005576//GO:0005634 interleukin-2 receptor complex//extracellular region//nucleus -- -- Cluster-8309.33781 BP_3 1014.17 19.49 2800 642915045 XP_008190387.1 557 4.7e-54 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like isoform X2 [Tribolium castaneum]>gi|270001363|gb|EEZ97810.1| hypothetical protein TcasGA2_TC000174 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QPN6 268 6.3e-22 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 PF00859 CTF/NF-I family transcription modulation region GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.33783 BP_3 77.49 4.18 1186 642930146 XP_008196271.1 1234 6.2e-133 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X5 [Tribolium castaneum] 189164165 EU545256.1 262 1.19478e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 893 8.9e-95 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.33786 BP_3 92.44 2.12 2396 642937283 XP_008198771.1 222 2.8e-15 PREDICTED: uncharacterized protein LOC103314450 isoform X2 [Tribolium castaneum]>gi|270000842|gb|EEZ97289.1| hypothetical protein TcasGA2_TC011094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33787 BP_3 704.06 8.15 4457 642913045 XP_008201364.1 6278 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] 642913044 XM_008203142.1 597 0 PREDICTED: Tribolium castaneum fibrillin-2 (LOC663193), mRNA -- -- -- -- Q61555 3315 0.0e+00 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.33788 BP_3 1769.94 19.83 4593 642919030 XP_008191704.1 2644 7.7e-296 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 642919029 XM_008193482.1 520 0 PREDICTED: Tribolium castaneum MAGUK p55 subfamily member 5-A (LOC663614), transcript variant X2, mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 Q8JHF4 1340 5.1e-146 MAGUK p55 subfamily member 5-A OS=Danio rerio GN=mpp5a PE=1 SV=2 PF13180//PF00018//PF14604//PF00595 PDZ domain//SH3 domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.33790 BP_3 46.13 3.56 916 189240524 XP_971875.2 546 2.9e-53 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] 808139336 XM_003400646.2 154 9.96983e-73 PREDICTED: Bombus terrestris 60S ribosomal protein L3 (LOC100646559), mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 498 4.4e-49 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.33791 BP_3 254.22 10.57 1451 761901546 XP_011404925.1 340 3.5e-29 PREDICTED: uncharacterized protein LOC100639010 [Amphimedon queenslandica] -- -- -- -- -- -- -- -- -- Q1RK13 304 2.2e-26 Putative ankyrin repeat protein RBE_0220 OS=Rickettsia bellii (strain RML369-C) GN=RBE_0220 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33794 BP_3 663.96 10.17 3439 478252006 ENN72441.1 2826 0.0e+00 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1423 9.1e-156 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF05173//PF01433 Dihydrodipicolinate reductase, C-terminus//Peptidase family M1 GO:0009089//GO:0009085//GO:0055114 lysine biosynthetic process via diaminopimelate//lysine biosynthetic process//oxidation-reduction process GO:0008839//GO:0008237//GO:0008270 4-hydroxy-tetrahydrodipicolinate reductase//metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.33797 BP_3 28.84 0.85 1932 91086655 XP_967836.1 1633 5.5e-179 PREDICTED: minor histocompatibility antigen H13 [Tribolium castaneum]>gi|270010389|gb|EFA06837.1| hypothetical protein TcasGA2_TC009780 [Tribolium castaneum] -- -- -- -- -- K09595 HM13 minor histocompatibility antigen H13 http://www.genome.jp/dbget-bin/www_bget?ko:K09595 Q8TCT9 1155 6.1e-125 Minor histocompatibility antigen H13 OS=Homo sapiens GN=HM13 PE=1 SV=1 PF01080//PF04258 Presenilin//Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.33799 BP_3 30.00 1.05 1664 215274049 ACJ64922.1 323 3.8e-27 nicotinic acetylcholine receptor alpha 8 [Leptinotarsa decemlineata] -- -- -- -- -- K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P25162 239 8.6e-19 Acetylcholine receptor subunit beta-like 2 OS=Drosophila melanogaster GN=nAChRbeta2 PE=2 SV=3 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.33803 BP_3 5883.84 194.08 1753 91087113 XP_975150.1 1013 3.9e-107 PREDICTED: ras-related protein Rab-1A [Tribolium castaneum]>gi|270010550|gb|EFA06998.1| hypothetical protein TcasGA2_TC009965 [Tribolium castaneum] 121543894 EF070546.1 188 2.44124e-91 Maconellicoccus hirsutus clone WHMH3840 putative RAB1 mRNA, complete cds K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q05974 930 6.8e-99 Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1 PF03193//PF00005//PF00071//PF10662//PF04670//PF01926//PF08477//PF07728//PF02421//PF00025//PF00004 Protein of unknown function, DUF258//ABC transporter//Ras family//Ethanolamine utilisation - propanediol utilisation//Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//Ferrous iron transport protein B//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA) GO:0006576//GO:0015031//GO:0015684//GO:0007264 cellular biogenic amine metabolic process//protein transport//ferrous iron transport//small GTPase mediated signal transduction GO:0005524//GO:0015093//GO:0003924//GO:0016887//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.33804 BP_3 2561.81 178.89 982 91091622 XP_969824.1 279 2.8e-22 PREDICTED: waprin-Rha1 [Tribolium castaneum]>gi|270001284|gb|EEZ97731.1| WAP four-disulfide core domain-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.33805 BP_3 36.66 0.57 3399 642919577 XP_008191928.1 2294 2.2e-255 PREDICTED: heat shock 70 kDa protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09485 HSP110 heat shock protein 110kDa http://www.genome.jp/dbget-bin/www_bget?ko:K09485 Q5R606 1519 6.6e-167 Heat shock protein 105 kDa OS=Pongo abelii GN=HSPH1 PE=2 SV=1 PF04355//PF06723 SmpA / OmlA family//MreB/Mbl protein GO:0000902 cell morphogenesis -- -- GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.33807 BP_3 35.73 0.82 2384 546674013 ERL85506.1 883 6.3e-92 hypothetical protein D910_02925 [Dendroctonus ponderosae] -- -- -- -- -- K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q06068 423 5.7e-40 97 kDa heat shock protein OS=Strongylocentrotus purpuratus PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.33808 BP_3 58.98 3.51 1102 91092196 XP_969285.1 382 3.6e-34 PREDICTED: plasminogen receptor (KT) isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HBL7 162 4.8e-10 Plasminogen receptor (KT) OS=Homo sapiens GN=PLGRKT PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33809 BP_3 691.35 7.64 4652 283046738 NP_001164316.1 941 2.3e-98 TAK1-associated binding protein 2 isoform A [Tribolium castaneum]>gi|270012754|gb|EFA09202.1| Tab2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K90 180 1.7e-11 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Mus musculus GN=Tab2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.33810 BP_3 22.17 0.73 1759 546683303 ERL93135.1 670 2.3e-67 hypothetical protein D910_10435 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 428 1.1e-40 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF06305 Trypsin//Protein of unknown function (DUF1049) GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.33811 BP_3 257.20 4.21 3234 546682290 ERL92248.1 263 6.7e-20 hypothetical protein D910_09565 [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 203 2.5e-14 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.33812 BP_3 5647.00 204.30 1624 91079180 XP_968196.1 313 5.4e-26 PREDICTED: cylicin-2 [Tribolium castaneum]>gi|270004244|gb|EFA00692.1| hypothetical protein TcasGA2_TC003571 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00951//PF06624 Arterivirus GL envelope glycoprotein//Ribosome associated membrane protein RAMP4 -- -- -- -- GO:0005783//GO:0019031 endoplasmic reticulum//viral envelope -- -- Cluster-8309.33814 BP_3 14.50 0.57 1525 91082991 XP_974304.1 320 7.8e-27 PREDICTED: 60S ribosomal protein L13a [Tribolium castaneum]>gi|270007030|gb|EFA03478.1| hypothetical protein TcasGA2_TC013477 [Tribolium castaneum] -- -- -- -- -- K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 Q962U0 236 1.8e-18 60S ribosomal protein L13a OS=Spodoptera frugiperda GN=RpL13A PE=2 SV=1 PF00707 Translation initiation factor IF-3, C-terminal domain GO:0042254//GO:0006412//GO:0006413 ribosome biogenesis//translation//translational initiation GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG3204 60S ribosomal protein L13a Cluster-8309.33815 BP_3 393.00 20.30 1225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.33816 BP_3 191.09 3.43 2975 546672114 ERL84135.1 1143 5.6e-122 hypothetical protein D910_01486 [Dendroctonus ponderosae]>gi|546675290|gb|ERL86521.1| hypothetical protein D910_03927 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NAG6 531 2.1e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.33817 BP_3 284.36 10.39 1611 91077474 XP_968267.1 2241 1.4e-249 PREDICTED: pleiotropic regulator 1 [Tribolium castaneum]>gi|642914017|ref|XP_008201512.1| PREDICTED: pleiotropic regulator 1 [Tribolium castaneum]>gi|270002139|gb|EEZ98586.1| hypothetical protein TcasGA2_TC001100 [Tribolium castaneum] -- -- -- -- -- K12862 PLRG1, PRL1, PRP46 pleiotropic regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12862 Q922V4 1517 5.3e-167 Pleiotropic regulator 1 OS=Mus musculus GN=Plrg1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0285 Pleiotropic regulator 1 Cluster-8309.33819 BP_3 13.16 1.10 867 195335719 XP_002034511.1 360 1.0e-31 GM21919 [Drosophila sechellia]>gi|194126481|gb|EDW48524.1| GM21919 [Drosophila sechellia] 195335718 XM_002034475.1 84 7.70282e-34 Drosophila sechellia GM21919 (Dsec\GM21919), mRNA K17081 PHB2 prohibitin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17081 O35129 304 1.3e-26 Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1 PF09367 CpeS-like protein GO:0017009 protein-phycocyanobilin linkage -- -- -- -- KOG3090 Prohibitin-like protein Cluster-8309.33820 BP_3 590.98 33.11 1152 91085035 XP_974101.1 1303 6.1e-141 PREDICTED: prohibitin-2 isoform X1 [Tribolium castaneum]>gi|270009028|gb|EFA05476.1| hypothetical protein TcasGA2_TC015660 [Tribolium castaneum] 195487314 XM_002091822.1 126 4.64275e-57 Drosophila yakuba GE12002 (Dyak\GE12002), partial mRNA K17081 PHB2 prohibitin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17081 Q99623 1042 4.6e-112 Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 -- -- -- -- -- -- GO:0016020 membrane KOG3090 Prohibitin-like protein Cluster-8309.33821 BP_3 10.07 0.34 1727 642910690 XP_008200062.1 440 1.1e-40 PREDICTED: serine protease snake [Tribolium castaneum]>gi|270015111|gb|EFA11559.1| serine protease P44 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 289 1.4e-24 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089//PF03340 Trypsin//Poxvirus rifampicin resistance protein GO:0046677//GO:0006508 response to antibiotic//proteolysis GO:0008236//GO:0004252 serine-type peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.33822 BP_3 314.00 4.22 3875 759068314 XP_011343656.1 171 3.7e-09 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X4 [Cerapachys biroi] 407731587 JQ771511.1 89 5.89475e-36 Labidomera clivicollis Na+,K+ ATPase alpha-subunit 1 mRNA, partial cds -- -- -- -- P28774 153 1.9e-08 Sodium/potassium-transporting ATPase subunit alpha-B OS=Artemia franciscana PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.33823 BP_3 211.00 7.07 1731 728418110 AIY68357.1 1347 7.2e-146 esterase [Leptinotarsa decemlineata] 685824196 LN609396.1 36 7.55696e-07 Strongyloides ratti genome assembly S_ratti_ED321 ,scaffold srae_chrx_scaffold0000002 -- -- -- -- B2D0J5 583 1.2e-58 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.33825 BP_3 302.44 3.19 4868 642935825 XP_008198191.1 4802 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum]>gi|642935827|ref|XP_008198192.1| PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum]>gi|642935829|ref|XP_008198193.1| PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 3.4e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.33826 BP_3 62.16 1.15 2893 332376827 AEE63553.1 2731 4.0e-306 unknown [Dendroctonus ponderosae] 759182915 XM_011381699.1 369 0 PREDICTED: Pteropus vampyrus protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant X1, mRNA K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 Q76MZ3 2356 5.0e-264 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus GN=Ppp2r1a PE=1 SV=3 PF02985//PF01602 HEAT repeat//Adaptin N terminal region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117 membrane coat KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.33827 BP_3 1480.47 31.71 2542 478255194 ENN75423.1 2734 1.6e-306 hypothetical protein YQE_07974, partial [Dendroctonus ponderosae] 759182915 XM_011381699.1 369 0 PREDICTED: Pteropus vampyrus protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant X1, mRNA K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 Q76MZ3 2356 4.3e-264 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus GN=Ppp2r1a PE=1 SV=3 PF02985//PF01602 HEAT repeat//Adaptin N terminal region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117 membrane coat KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.33829 BP_3 10640.22 131.93 4179 478251222 ENN71696.1 1228 1.1e-131 hypothetical protein YQE_11619, partial [Dendroctonus ponderosae] 315115388 HQ424723.1 158 2.79688e-74 Euphydryas aurinia ribosomal protein S15 (RpS15) mRNA, complete cds K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 Q9W6S3 537 6.0e-53 Target of rapamycin complex 2 subunit MAPKAP1 OS=Gallus gallus GN=MAPKAP1 PE=2 SV=1 PF00203//PF04145//PF00654 Ribosomal protein S19//Ctr copper transporter family//Voltage gated chloride channel GO:0006821//GO:0006825//GO:0006412//GO:0055085//GO:0042254//GO:0035434 chloride transport//copper ion transport//translation//transmembrane transport//ribosome biogenesis//copper ion transmembrane transport GO:0005375//GO:0003735//GO:0005247 copper ion transmembrane transporter activity//structural constituent of ribosome//voltage-gated chloride channel activity GO:0016021//GO:0005840//GO:0016020 integral component of membrane//ribosome//membrane KOG0898 40S ribosomal protein S15 Cluster-8309.33830 BP_3 542.97 33.67 1069 642937828 XP_008200318.1 731 1.2e-74 PREDICTED: ethanolamine kinase 2 [Tribolium castaneum] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 P54352 576 4.6e-58 Ethanolamine kinase OS=Drosophila melanogaster GN=eas PE=1 SV=2 PF05296 Taste receptor protein (TAS2R) GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4720 Ethanolamine kinase Cluster-8309.33831 BP_3 683.51 8.61 4119 642937828 XP_008200318.1 862 3.0e-89 PREDICTED: ethanolamine kinase 2 [Tribolium castaneum] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 P54352 835 1.7e-87 Ethanolamine kinase OS=Drosophila melanogaster GN=eas PE=1 SV=2 PF05296 Taste receptor protein (TAS2R) GO:0050909//GO:0007186 sensory perception of taste//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4720 Ethanolamine kinase Cluster-8309.33833 BP_3 42.37 0.96 2427 642933276 XP_008197354.1 1014 4.1e-107 PREDICTED: cell wall protein RBR3 isoform X1 [Tribolium castaneum] 817211936 XM_012426709.1 59 1.74603e-19 PREDICTED: Orussus abietinus uncharacterized LOC105700657 (LOC105700657), mRNA -- -- -- -- Q96NU1 194 2.1e-13 Sterile alpha motif domain-containing protein 11 OS=Homo sapiens GN=SAMD11 PE=2 SV=3 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33835 BP_3 52.00 16.73 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33838 BP_3 125.12 1.11 5732 546675238 ERL86474.1 1956 5.8e-216 hypothetical protein D910_03880 [Dendroctonus ponderosae] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q54G06 923 1.4e-97 Xaa-Pro aminopeptidase 1 OS=Dictyostelium discoideum GN=xpnpep1 PE=3 SV=1 PF01398//PF04961//PF02723//PF10278//PF01321 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//Non-structural protein NS3/Small envelope protein E//Mediator of RNA pol II transcription subunit 19//Creatinase/Prolidase N-terminal domain GO:0044237//GO:0006357 cellular metabolic process//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0016787//GO:0001104//GO:0003824 protein binding//hydrolase activity//RNA polymerase II transcription cofactor activity//catalytic activity GO:0016592//GO:0016020 mediator complex//membrane KOG2413 Xaa-Pro aminopeptidase Cluster-8309.33839 BP_3 1258.00 32.08 2182 -- -- -- -- -- 301172695 NR_036272.1 47 7.34323e-13 Tribolium castaneum microRNA mir-1 (Mir1), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33840 BP_3 289.10 5.84 2677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33841 BP_3 275.29 2.80 5032 270002885 EEZ99332.1 703 9.9e-71 serine protease P46 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75096 311 1.2e-26 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF03875//PF00057//PF07415//PF00089 Statherin//Low-density lipoprotein receptor domain class A//Gammaherpesvirus latent membrane protein (LMP2) protein//Trypsin GO:0030500//GO:0042742//GO:0019042//GO:0006508 regulation of bone mineralization//defense response to bacterium//viral latency//proteolysis GO:0046848//GO:0005515//GO:0004252 hydroxyapatite binding//protein binding//serine-type endopeptidase activity GO:0005576//GO:0033644 extracellular region//host cell membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.33843 BP_3 235.90 29.82 673 478250183 ENN70686.1 762 1.9e-78 hypothetical protein YQE_12631, partial [Dendroctonus ponderosae]>gi|546682381|gb|ERL92323.1| hypothetical protein D910_09640 [Dendroctonus ponderosae] -- -- -- -- -- K03952 NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03952 Q9DCJ5 352 2.7e-32 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Mus musculus GN=Ndufa8 PE=1 SV=3 PF05676//PF02297 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Cytochrome oxidase c subunit VIb GO:0015992//GO:0006814//GO:0006118//GO:0006744//GO:0006123//GO:0006120 proton transport//sodium ion transport//obsolete electron transport//ubiquinone biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//mitochondrial electron transport, NADH to ubiquinone GO:0004129//GO:0008137//GO:0003954 cytochrome-c oxidase activity//NADH dehydrogenase (ubiquinone) activity//NADH dehydrogenase activity GO:0005739//GO:0045277 mitochondrion//respiratory chain complex IV KOG3458 NADH:ubiquinone oxidoreductase, NDUFA8/PGIV/19 kDa subunit Cluster-8309.33844 BP_3 425.03 5.19 4236 91081353 XP_971021.1 1303 2.2e-140 PREDICTED: protein FAM114A2 [Tribolium castaneum]>gi|270005192|gb|EFA01640.1| hypothetical protein TcasGA2_TC007210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDV3 509 1.1e-49 Probable nucleoporin Nup58 OS=Drosophila melanogaster GN=Nup58 PE=2 SV=1 PF14620//PF08515//PF04029//PF00435 YpeB sporulation//Transforming growth factor beta type I GS-motif//2-phosphosulpholactate phosphatase//Spectrin repeat GO:0009847//GO:0016310//GO:0006468//GO:0009069//GO:0007178 spore germination//phosphorylation//protein phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0000287//GO:0050532//GO:0004675//GO:0005515//GO:0005524 magnesium ion binding//2-phosphosulfolactate phosphatase activity//transmembrane receptor protein serine/threonine kinase activity//protein binding//ATP binding GO:0016020 membrane KOG0845 Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) Cluster-8309.33846 BP_3 977.60 58.30 1100 91077560 XP_972368.1 1371 7.5e-149 PREDICTED: sorbitol dehydrogenase [Tribolium castaneum]>gi|270002168|gb|EEZ98615.1| hypothetical protein TcasGA2_TC001137 [Tribolium castaneum] -- -- -- -- -- K00008 SORD, gutB L-iditol 2-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00008 Q58D31 981 5.2e-105 Sorbitol dehydrogenase OS=Bos taurus GN=SORD PE=2 SV=3 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0008270//GO:0000166//GO:0016491//GO:0046872 zinc ion binding//nucleotide binding//oxidoreductase activity//metal ion binding -- -- KOG0024 Sorbitol dehydrogenase Cluster-8309.33847 BP_3 1889.24 47.49 2209 332374856 AEE62569.1 2227 8.3e-248 unknown [Dendroctonus ponderosae] 769836104 XM_011649878.1 162 8.77338e-77 PREDICTED: Pogonomyrmex barbatus T-complex protein 1 subunit epsilon (LOC105434223), mRNA K09497 CCT5 T-complex protein 1 subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09497 Q4R6V2 1924 4.7e-214 T-complex protein 1 subunit epsilon OS=Macaca fascicularis GN=CCT5 PE=2 SV=1 PF00118//PF07546 TCP-1/cpn60 chaperonin family//EMI domain -- -- GO:0005515//GO:0005524 protein binding//ATP binding -- -- KOG0357 Chaperonin complex component, TCP-1 epsilon subunit (CCT5) Cluster-8309.33848 BP_3 1020.84 21.10 2624 91087475 XP_967673.1 2015 3.8e-223 PREDICTED: 26S protease regulatory subunit 6A-B [Tribolium castaneum]>gi|270010662|gb|EFA07110.1| hypothetical protein TcasGA2_TC010100 [Tribolium castaneum] 54287935 AY750868.1 407 0 Toxoptera citricida putative 26S protease regulatory subunit 6A mRNA, complete cds K03065 PSMC3, RPT5 26S proteasome regulatory subunit T5 http://www.genome.jp/dbget-bin/www_bget?ko:K03065 Q63569 1805 3.5e-200 26S protease regulatory subunit 6A OS=Rattus norvegicus GN=Psmc3 PE=2 SV=1 PF00005//PF02562//PF00910//PF07728//PF01695//PF00158//PF05496//PF00004//PF07724 ABC transporter//PhoH-like protein//RNA helicase//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily) GO:0006281//GO:0006355//GO:0006310//GO:0030163 DNA repair//regulation of transcription, DNA-templated//DNA recombination//protein catabolic process GO:0005524//GO:0003723//GO:0008134//GO:0016887//GO:0017111//GO:0009378//GO:0003724 ATP binding//RNA binding//transcription factor binding//ATPase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//RNA helicase activity GO:0005657//GO:0009379//GO:0005667//GO:0005737 replication fork//Holliday junction helicase complex//transcription factor complex//cytoplasm KOG0652 26S proteasome regulatory complex, ATPase RPT5 Cluster-8309.33851 BP_3 487.80 3.20 7647 642933138 XP_008197272.1 7873 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 13 isoform X1 [Tribolium castaneum] 642933139 XM_008199051.1 239 4.81898e-119 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 2.8e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF14672//PF06333//PF02671 Late cornified envelope//Mediator complex subunit 13 C-terminal//Paired amphipathic helix repeat GO:0006355//GO:0006357//GO:0008544 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//epidermis development GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.33852 BP_3 14.53 0.35 2302 546676160 ERL87227.1 599 5.2e-59 hypothetical protein D910_04625 [Dendroctonus ponderosae] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 Q8TF62 275 8.0e-23 Probable phospholipid-transporting ATPase IM OS=Homo sapiens GN=ATP8B4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0206 P-type ATPase Cluster-8309.33853 BP_3 21396.87 236.85 4646 91078972 XP_974414.1 2664 3.7e-298 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 1610 2.5e-177 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0046872//GO:0003810 metal ion binding//protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.33855 BP_3 54.23 0.82 3478 91078972 XP_974414.1 2195 6.8e-244 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 Q05187 1344 1.3e-146 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.33856 BP_3 1332.86 12.05 5624 642937777 XP_008198941.1 5493 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X3 [Tribolium castaneum] 665815760 XM_008558331.1 166 1.34722e-78 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 3294 0.0e+00 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0206 P-type ATPase Cluster-8309.33857 BP_3 4663.37 349.42 935 642925507 XP_008194579.1 284 7.1e-23 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane -- -- Cluster-8309.33858 BP_3 657.06 12.42 2842 642925507 XP_008194579.1 1060 2.3e-112 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.42634e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 773 1.8e-80 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.33859 BP_3 703.31 8.42 4320 642937760 XP_008198934.1 1304 1.7e-140 PREDICTED: mortality factor 4-like protein 1 [Tribolium castaneum]>gi|270001152|gb|EEZ97599.1| hypothetical protein TcasGA2_TC011468 [Tribolium castaneum] 807018879 XM_004519732.2 70 2.3996e-25 PREDICTED: Ceratitis capitata nuA4 complex subunit EAF3 homolog (LOC101448544), mRNA K11339 MORF4L1, MRG15, EAF3 mortality factor 4-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11339 Q6AYU1 950 8.0e-101 Mortality factor 4-like protein 1 OS=Rattus norvegicus GN=Morf4l1 PE=2 SV=1 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.33860 BP_3 125.68 5.00 1503 91086669 XP_968223.1 832 3.3e-86 PREDICTED: proteasomal ubiquitin receptor ADRM1 [Tribolium castaneum]>gi|270010393|gb|EFA06841.1| hypothetical protein TcasGA2_TC009784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K2G1 548 1.1e-54 Proteasomal ubiquitin receptor ADRM1 homolog OS=Drosophila melanogaster GN=Rpn13 PE=1 SV=1 PF04683//PF05460//PF03999 Proteasome complex subunit Rpn13 ubiquitin receptor//Origin recognition complex subunit 6 (ORC6)//Microtubule associated protein (MAP65/ASE1 family) GO:0000226//GO:0006260//GO:0000910 microtubule cytoskeleton organization//DNA replication//cytokinesis GO:0008017//GO:0003677 microtubule binding//DNA binding GO:0005737//GO:0045298//GO:0005664//GO:0005634 cytoplasm//tubulin complex//nuclear origin of replication recognition complex//nucleus KOG3037 Cell membrane glycoprotein Cluster-8309.33861 BP_3 199.58 7.93 1505 642936042 XP_008198279.1 685 3.6e-69 PREDICTED: annexin B9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 525 5.3e-52 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF04546//PF00191 Sigma-70, non-essential region//Annexin GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0005544//GO:0003700//GO:0005509//GO:0016987//GO:0003677 calcium-dependent phospholipid binding//transcription factor activity, sequence-specific DNA binding//calcium ion binding//sigma factor activity//DNA binding GO:0005667 transcription factor complex KOG0819 Annexin Cluster-8309.33862 BP_3 101.69 1.06 4911 91092640 XP_969145.1 1955 6.4e-216 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1246 4.3e-135 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 PF00628 PHD-finger -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005634 nucleus KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.33866 BP_3 4178.70 125.86 1892 332373948 AEE62115.1 1084 2.5e-115 unknown [Dendroctonus ponderosae]>gi|478255033|gb|ENN75265.1| hypothetical protein YQE_08181, partial [Dendroctonus ponderosae]>gi|546673321|gb|ERL84949.1| hypothetical protein D910_02372 [Dendroctonus ponderosae] 332373947 BT127153.1 266 1.15196e-134 Dendroctonus ponderosae clone DPO1136_C15 unknown mRNA K07904 RAB11A Ras-related protein Rab-11A http://www.genome.jp/dbget-bin/www_bget?ko:K07904 P62493 907 3.4e-96 Ras-related protein Rab-11A OS=Oryctolagus cuniculus GN=RAB11A PE=2 SV=3 PF01926//PF07728//PF08477//PF02421//PF00025//PF03193//PF00005//PF10662//PF00071//PF04670 50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//Protein of unknown function, DUF258//ABC transporter//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region GO:0015684//GO:0007264//GO:0006576 ferrous iron transport//small GTPase mediated signal transduction//cellular biogenic amine metabolic process GO:0016887//GO:0005525//GO:0005524//GO:0015093//GO:0003924 ATPase activity//GTP binding//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG0087 GTPase Rab11/YPT3, small G protein superfamily Cluster-8309.33867 BP_3 498.87 15.74 1819 642919181 XP_008191771.1 737 4.1e-75 PREDICTED: uncharacterized protein LOC103312580 isoform X1 [Tribolium castaneum]>gi|270005582|gb|EFA02030.1| hypothetical protein TcasGA2_TC007655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33868 BP_3 187.39 4.78 2182 642913109 XP_008201396.1 838 9.6e-87 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 746862007 XM_011063600.1 170 3.09431e-81 PREDICTED: Acromyrmex echinatior protein GDAP2 homolog (LOC105150477), mRNA -- -- -- -- Q7JUR6 686 1.7e-70 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.33872 BP_3 6752.98 291.59 1408 91082141 XP_969473.1 765 1.8e-78 PREDICTED: integral membrane protein 2A [Tribolium castaneum]>gi|270007252|gb|EFA03700.1| hypothetical protein TcasGA2_TC013805 [Tribolium castaneum] -- -- -- -- -- K18264 ITM2B integral membrane protein 2B http://www.genome.jp/dbget-bin/www_bget?ko:K18264 Q3T0P7 179 6.6e-12 Integral membrane protein 2B OS=Bos taurus GN=ITM2B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4681 Uncharacterized conserved protein Cluster-8309.33873 BP_3 950.00 27.35 1966 478260661 ENN80358.1 1568 1.9e-171 hypothetical protein YQE_03217, partial [Dendroctonus ponderosae]>gi|546683693|gb|ERL93471.1| hypothetical protein D910_10762 [Dendroctonus ponderosae] 766923044 XM_011507823.1 252 7.26048e-127 PREDICTED: Ceratosolen solmsi marchali protein Mo25 (LOC105368736), transcript variant X2, mRNA K08272 CAB39, MO25 calcium binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K08272 P91891 1408 2.8e-154 Protein Mo25 OS=Drosophila melanogaster GN=Mo25 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1566 Conserved protein Mo25 Cluster-8309.33875 BP_3 27.18 0.31 4469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33876 BP_3 69.61 0.62 5670 752876259 XP_011255518.1 494 1.9e-46 PREDICTED: 60S ribosomal protein L44 [Camponotus floridanus] 642918893 XM_968530.2 160 2.94023e-75 PREDICTED: Tribolium castaneum 60S ribosomal protein L44 (LOC662436), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q9NB33 450 1.0e-42 60S ribosomal protein L44 OS=Ochlerotatus triseriatus GN=RpL44 PE=3 SV=3 PF00935//PF10152//PF02150 Ribosomal protein L44//Predicted coiled-coil domain-containing protein (DUF2360)//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006412//GO:0006206//GO:0042254 transcription, DNA-templated//purine nucleobase metabolic process//translation//pyrimidine nucleobase metabolic process//ribosome biogenesis GO:0003899//GO:0003677//GO:0003735 DNA-directed RNA polymerase activity//DNA binding//structural constituent of ribosome GO:0005840//GO:0005622//GO:0071203//GO:0005730 ribosome//intracellular//WASH complex//nucleolus KOG3464 60S ribosomal protein L44 Cluster-8309.33878 BP_3 3101.00 35.75 4473 91076478 XP_972409.1 5369 0.0e+00 PREDICTED: slit homolog 3 protein [Tribolium castaneum]>gi|270002880|gb|EEZ99327.1| toll-7-like protein [Tribolium castaneum] 642912522 XM_967316.2 956 0 PREDICTED: Tribolium castaneum toll-like receptor 7 (LOC661135), mRNA -- -- -- -- P35859 435 4.3e-41 Insulin-like growth factor-binding protein complex acid labile subunit OS=Rattus norvegicus GN=Igfals PE=1 SV=1 PF01582//PF00560//PF13676//PF13855 TIR domain//Leucine Rich Repeat//TIR domain//Leucine rich repeat GO:0007165 signal transduction GO:0005515 protein binding GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.33880 BP_3 604.56 5.86 5262 270002723 EEZ99170.1 3733 0.0e+00 aminopeptidase-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P79098 740 2.2e-76 Aminopeptidase N OS=Bos taurus GN=ANPEP PE=2 SV=4 PF01433//PF02671 Peptidase family M1//Paired amphipathic helix repeat GO:0006355 regulation of transcription, DNA-templated GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.33881 BP_3 374.97 1.95 9573 642922938 XP_008200459.1 3758 0.0e+00 PREDICTED: symplekin [Tribolium castaneum]>gi|270006545|gb|EFA02993.1| hypothetical protein TcasGA2_TC010414 [Tribolium castaneum] -- -- -- -- -- K06100 SYMPK symplekin http://www.genome.jp/dbget-bin/www_bget?ko:K06100 Q8IYB9 457 2.6e-43 Zinc finger protein 595 OS=Homo sapiens GN=ZNF595 PE=2 SV=1 PF00096//PF00312//PF12689//PF14764//PF13465//PF01025//PF13912//PF03938//PF10018 Zinc finger, C2H2 type//Ribosomal protein S15//Acid Phosphatase//AP-5 complex subunit, vesicle trafficking//Zinc-finger double domain//GrpE//C2H2-type zinc finger//Outer membrane protein (OmpH-like)//Vitamin-D-receptor interacting Mediator subunit 4 GO:0042254//GO:0006357//GO:0006412//GO:0006457 ribosome biogenesis//regulation of transcription from RNA polymerase II promoter//translation//protein folding GO:0003735//GO:0051087//GO:0051082//GO:0000774//GO:0016791//GO:0001104//GO:0046872//GO:0042803 structural constituent of ribosome//chaperone binding//unfolded protein binding//adenyl-nucleotide exchange factor activity//phosphatase activity//RNA polymerase II transcription cofactor activity//metal ion binding//protein homodimerization activity GO:0005840//GO:0005622//GO:0044599//GO:0016592 ribosome//intracellular//AP-5 adaptor complex//mediator complex -- -- Cluster-8309.33882 BP_3 71.76 2.11 1933 546673062 ERL84739.1 956 1.8e-100 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AYT7 425 2.7e-40 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF10503//PF07859//PF01764//PF11112 Esterase PHB depolymerase//alpha/beta hydrolase fold//Lipase (class 3)//Pyocin activator protein PrtN GO:0006355//GO:0008152//GO:0006629 regulation of transcription, DNA-templated//metabolic process//lipid metabolic process GO:0016787 hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.33884 BP_3 313.99 8.03 2177 91080457 XP_969840.1 2089 8.3e-232 PREDICTED: TBC1 domain family member 15 [Tribolium castaneum]>gi|270005762|gb|EFA02210.1| hypothetical protein TcasGA2_TC007868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TC07 946 1.2e-100 TBC1 domain family member 15 OS=Homo sapiens GN=TBC1D15 PE=1 SV=2 -- -- -- -- -- -- GO:0005622 intracellular KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.33885 BP_3 577.11 8.91 3412 91080457 XP_969840.1 2275 3.5e-253 PREDICTED: TBC1 domain family member 15 [Tribolium castaneum]>gi|270005762|gb|EFA02210.1| hypothetical protein TcasGA2_TC007868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CXF4 1015 1.8e-108 TBC1 domain family member 15 OS=Mus musculus GN=Tbc1d15 PE=1 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.33887 BP_3 545.68 3.51 7795 546673544 ERL85123.1 3649 0.0e+00 hypothetical protein D910_02545 [Dendroctonus ponderosae] 156845530 XM_001645606.1 61 4.37497e-20 Vanderwaltozyma polyspora DSM 70294 hypothetical protein (Kpol_541p40) partial mRNA K12618 XRN1, SEP1, KEM1 5'-3' exoribonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12618 P97789 2567 4.6e-288 5'-3' exoribonuclease 1 OS=Mus musculus GN=Xrn1 PE=1 SV=1 PF03159//PF04117 XRN 5'-3' exonuclease N-terminus//Mpv17 / PMP22 family -- -- GO:0004527//GO:0003676 exonuclease activity//nucleic acid binding GO:0016021 integral component of membrane KOG2044 5'-3' exonuclease HKE1/RAT1 Cluster-8309.33888 BP_3 39.00 0.83 2547 478252680 ENN73076.1 265 3.1e-20 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3389 BP_3 9.49 0.63 1018 642919879 XP_973964.2 335 9.4e-29 PREDICTED: ganglioside GM2 activator [Tribolium castaneum] -- -- -- -- -- K12383 GM2A ganglioside GM2 activator http://www.genome.jp/dbget-bin/www_bget?ko:K12383 Q8HXX6 174 1.8e-11 Ganglioside GM2 activator OS=Macaca fascicularis GN=GM2A PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33890 BP_3 1354.00 50.19 1592 642910713 XP_008200528.1 734 8.0e-75 PREDICTED: serine-arginine protein 55-like isoform X1 [Tribolium castaneum] 462281002 APGK01057804.1 120 1.39916e-53 Dendroctonus ponderosae Seq01057814, whole genome shotgun sequence K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 629 4.9e-64 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF16367//PF11744//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Aluminium activated malate transporter//RNA binding motif GO:0015743 malate transport GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.33891 BP_3 206.99 3.64 3032 478250426 ENN70921.1 505 5.4e-48 hypothetical protein YQE_12323, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BLW3 163 1.0e-09 Leucine-rich repeat-containing G-protein coupled receptor 4 OS=Xenopus tropicalis GN=lgr4 PE=1 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33892 BP_3 23.00 0.72 1822 642914825 XP_008194954.1 756 2.6e-77 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q8VI78 354 4.3e-32 Phospholipase A1 member A OS=Mus musculus GN=Pla1a PE=2 SV=3 PF02230 Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.33893 BP_3 205.00 26.19 669 288860140 NP_001165842.1 181 4.5e-11 uracil-DNA degrading factor [Tribolium castaneum]>gi|270002992|gb|EEZ99439.1| hypothetical protein TcasGA2_TC030651 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05470//PF06213//PF01080//PF02724//PF03985 Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Cobalamin biosynthesis protein CobT//Presenilin//CDC45-like protein//Paf1 GO:0006368//GO:0006446//GO:0006270//GO:0009236//GO:0006413//GO:0016570 transcription elongation from RNA polymerase II promoter//regulation of translational initiation//DNA replication initiation//cobalamin biosynthetic process//translational initiation//histone modification GO:0004190//GO:0003743//GO:0031369 aspartic-type endopeptidase activity//translation initiation factor activity//translation initiation factor binding GO:0016593//GO:0016021//GO:0005852//GO:0005840 Cdc73/Paf1 complex//integral component of membrane//eukaryotic translation initiation factor 3 complex//ribosome -- -- Cluster-8309.33895 BP_3 22.00 0.72 1768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33897 BP_3 20.16 0.72 1637 189234454 XP_967960.2 1786 8.5e-197 PREDICTED: aldehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270002022|gb|EEZ98469.1| hypothetical protein TcasGA2_TC000960 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 Q5RF00 1447 7.1e-159 Aldehyde dehydrogenase, mitochondrial OS=Pongo abelii GN=ALDH2 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0016620 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.33899 BP_3 189.59 1.91 5065 546681087 ERL91243.1 3068 0.0e+00 hypothetical protein D910_08578 [Dendroctonus ponderosae] -- -- -- -- -- K16685 WWC1 protein KIBRA http://www.genome.jp/dbget-bin/www_bget?ko:K16685 B4K6I9 1037 7.7e-111 Protein kibra OS=Drosophila mojavensis GN=Kibra PE=3 SV=1 PF05180//PF01253//PF00397//PF00168 DNL zinc finger//Translation initiation factor SUI1//WW domain//C2 domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0008270//GO:0003743//GO:0005515 zinc ion binding//translation initiation factor activity//protein binding GO:0005840 ribosome -- -- Cluster-8309.339 BP_3 3.00 2.19 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3390 BP_3 6.51 0.38 1109 642919879 XP_973964.2 335 1.0e-28 PREDICTED: ganglioside GM2 activator [Tribolium castaneum] -- -- -- -- -- K12383 GM2A ganglioside GM2 activator http://www.genome.jp/dbget-bin/www_bget?ko:K12383 Q8HXX6 174 2.0e-11 Ganglioside GM2 activator OS=Macaca fascicularis GN=GM2A PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33900 BP_3 31.92 0.33 4999 546681087 ERL91243.1 3130 0.0e+00 hypothetical protein D910_08578 [Dendroctonus ponderosae] -- -- -- -- -- K16685 WWC1 protein KIBRA http://www.genome.jp/dbget-bin/www_bget?ko:K16685 B4M5X4 786 9.6e-82 Protein kibra OS=Drosophila virilis GN=Kibra PE=3 SV=1 PF00168//PF01253//PF05180 C2 domain//Translation initiation factor SUI1//DNL zinc finger GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743//GO:0008270//GO:0005515 translation initiation factor activity//zinc ion binding//protein binding GO:0005840 ribosome -- -- Cluster-8309.33901 BP_3 566.84 5.47 5287 642925611 XP_008194640.1 2652 1.0e-296 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 2.3e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33903 BP_3 2270.43 52.35 2382 91080995 XP_975051.1 1985 1.0e-219 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 731415861 XM_010661396.1 41 1.7376e-09 PREDICTED: Vitis vinifera calreticulin (LOC100256319), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P27824 1374 3.0e-150 Calnexin OS=Homo sapiens GN=CANX PE=1 SV=2 PF13965//PF03348//PF02535//PF03896//PF05699//PF00262 dsRNA-gated channel SID-1//Serine incorporator (Serinc)//ZIP Zinc transporter//Translocon-associated protein (TRAP), alpha subunit//hAT family C-terminal dimerisation region//Calreticulin family GO:0033227//GO:0015931//GO:0030001//GO:0006457//GO:0055085 dsRNA transport//nucleobase-containing compound transport//metal ion transport//protein folding//transmembrane transport GO:0005509//GO:0051082//GO:0051033//GO:0046873//GO:0046983 calcium ion binding//unfolded protein binding//RNA transmembrane transporter activity//metal ion transmembrane transporter activity//protein dimerization activity GO:0016020//GO:0016021//GO:0005789//GO:0005783 membrane//integral component of membrane//endoplasmic reticulum membrane//endoplasmic reticulum KOG0675 Calnexin Cluster-8309.33904 BP_3 56.19 1.25 2464 91080995 XP_975051.1 1067 3.0e-113 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 641647106 XM_003240040.2 39 2.32626e-08 PREDICTED: Acyrthosiphon pisum calreticulin-like (LOC100161399), mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 Q5R440 738 1.7e-76 Calnexin OS=Pongo abelii GN=CANX PE=2 SV=2 PF00262//PF02535//PF02487//PF07850//PF13965//PF01080//PF04147//PF05699//PF02932//PF03348 Calreticulin family//ZIP Zinc transporter//CLN3 protein//Renin receptor-like protein//dsRNA-gated channel SID-1//Presenilin//Nop14-like family//hAT family C-terminal dimerisation region//Neurotransmitter-gated ion-channel transmembrane region//Serine incorporator (Serinc) GO:0033227//GO:0055085//GO:0015931//GO:0007165//GO:0006811//GO:0006457//GO:0030001 dsRNA transport//transmembrane transport//nucleobase-containing compound transport//signal transduction//ion transport//protein folding//metal ion transport GO:0051082//GO:0051033//GO:0046873//GO:0005509//GO:0004872//GO:0046983//GO:0004190 unfolded protein binding//RNA transmembrane transporter activity//metal ion transmembrane transporter activity//calcium ion binding//receptor activity//protein dimerization activity//aspartic-type endopeptidase activity GO:0032040//GO:0016021//GO:0016020//GO:0005783 small-subunit processome//integral component of membrane//membrane//endoplasmic reticulum KOG0675 Calnexin Cluster-8309.33905 BP_3 72.72 1.69 2367 91080995 XP_975051.1 1818 2.4e-200 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 731415861 XM_010661396.1 41 1.72649e-09 PREDICTED: Vitis vinifera calreticulin (LOC100256319), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P35565 1345 6.9e-147 Calnexin OS=Rattus norvegicus GN=Canx PE=1 SV=1 PF02487//PF03896//PF02535//PF00262//PF01080 CLN3 protein//Translocon-associated protein (TRAP), alpha subunit//ZIP Zinc transporter//Calreticulin family//Presenilin GO:0030001//GO:0055085//GO:0006457 metal ion transport//transmembrane transport//protein folding GO:0004190//GO:0005488//GO:0051082//GO:0005509//GO:0046873 aspartic-type endopeptidase activity//binding//unfolded protein binding//calcium ion binding//metal ion transmembrane transporter activity GO:0016021//GO:0005789//GO:0005783//GO:0016020 integral component of membrane//endoplasmic reticulum membrane//endoplasmic reticulum//membrane KOG0675 Calnexin Cluster-8309.33906 BP_3 93.17 1.17 4130 478255030 ENN75262.1 1413 3.8e-153 hypothetical protein YQE_08178, partial [Dendroctonus ponderosae]>gi|546673318|gb|ERL84946.1| hypothetical protein D910_02369 [Dendroctonus ponderosae] 663266156 XM_008495200.1 48 3.89197e-13 PREDICTED: Calypte anna p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), mRNA K04409 PAK1 p21-activated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04409 Q29502 862 1.2e-90 Serine/threonine-protein kinase PAK 2 OS=Oryctolagus cuniculus GN=PAK2 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.33907 BP_3 1549.83 23.71 3442 478255030 ENN75262.1 1806 8.6e-199 hypothetical protein YQE_08178, partial [Dendroctonus ponderosae]>gi|546673318|gb|ERL84946.1| hypothetical protein D910_02369 [Dendroctonus ponderosae] 663266156 XM_008495200.1 48 3.23792e-13 PREDICTED: Calypte anna p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), mRNA K04409 PAK1 p21-activated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04409 P35465 928 2.3e-98 Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.33908 BP_3 1504.55 5.15 14380 189237595 XP_966729.2 2234 8.4e-248 PREDICTED: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [Tribolium castaneum] 642910997 XM_008195279.1 320 8.52233e-164 PREDICTED: Tribolium castaneum single-stranded DNA-binding protein 3 (LOC662190), transcript variant X4, mRNA K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 P49071 1432 3.4e-156 MAP kinase-activated protein kinase 2 OS=Drosophila melanogaster GN=MAPk-Ak2 PE=2 SV=1 PF00069//PF09029//PF07714//PF06293//PF01212//PF01053//PF00155//PF08001//PF06016 Protein kinase domain//5-aminolevulinate synthase presequence//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II//CMV US//Reovirus core-spike protein lambda-2 (L2) GO:0006520//GO:0006544//GO:0006783//GO:0030683//GO:0009451//GO:0006370//GO:0009058//GO:0006566//GO:0006778//GO:0042967//GO:0006468//GO:0006563 cellular amino acid metabolic process//glycine metabolic process//heme biosynthetic process//evasion or tolerance by virus of host immune response//RNA modification//7-methylguanosine mRNA capping//biosynthetic process//threonine metabolic process//porphyrin-containing compound metabolic process//acyl-carrier-protein biosynthetic process//protein phosphorylation//L-serine metabolic process GO:0004672//GO:0016773//GO:0004484//GO:0003870//GO:0030170//GO:0004482//GO:0016829//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//mRNA guanylyltransferase activity//5-aminolevulinate synthase activity//pyridoxal phosphate binding//mRNA (guanine-N7-)-methyltransferase activity//lyase activity//ATP binding GO:0005759//GO:0016020//GO:0044386//GO:0019028 mitochondrial matrix//membrane//integral to host endoplasmic reticulum membrane//viral capsid KOG0604 MAP kinase-activated protein kinase 2 Cluster-8309.33910 BP_3 63.14 1.23 2764 443707618 ELU03131.1 1019 1.2e-107 hypothetical protein CAPTEDRAFT_198317 [Capitella teleta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 935 2.8e-99 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF01842//PF13465//PF00096//PF16622//PF13912 ACT domain//Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//C2H2-type zinc finger GO:0008152 metabolic process GO:0016597//GO:0046872 amino acid binding//metal ion binding -- -- -- -- Cluster-8309.33912 BP_3 267.00 17.67 1020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33914 BP_3 101.41 6.48 1046 91082539 XP_973726.1 660 2.0e-66 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 1.6e-23 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.33915 BP_3 586.14 13.92 2322 332377013 AEE63646.1 1104 1.5e-117 unknown [Dendroctonus ponderosae]>gi|478253342|gb|ENN73703.1| hypothetical protein YQE_09700, partial [Dendroctonus ponderosae]>gi|546673935|gb|ERL85446.1| hypothetical protein D910_02865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VD07 261 3.4e-21 Neuronal membrane glycoprotein M6-a OS=Bos taurus GN=GPM6A PE=2 SV=1 PF01275 Myelin proteolipid protein (PLP or lipophilin) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33916 BP_3 390.12 7.35 2851 642933386 XP_008197395.1 2403 4.2e-268 PREDICTED: HEAT repeat-containing protein 2 [Tribolium castaneum]>gi|270011379|gb|EFA07827.1| hypothetical protein TcasGA2_TC005396 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q86Y56 978 3.0e-104 Dynein assembly factor 5, axonemal OS=Homo sapiens GN=DNAAF5 PE=1 SV=4 PF11640//PF02985 Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0005515 protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.33919 BP_3 668.04 14.86 2458 91087167 XP_975374.1 1359 4.2e-147 PREDICTED: putative deoxyribonuclease TATDN1 [Tribolium castaneum]>gi|270010559|gb|EFA07007.1| hypothetical protein TcasGA2_TC009977 [Tribolium castaneum] -- -- -- -- -- K03424 tatD TatD DNase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03424 Q9L6M2 559 1.0e-55 Tat-linked quality control protein TatD OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=tatD PE=3 SV=1 PF01026 TatD related DNase GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3020 TatD-related DNase Cluster-8309.33920 BP_3 389.81 6.88 3023 642918838 XP_008191608.1 2515 4.6e-281 PREDICTED: breast carcinoma-amplified sequence 3 homolog isoform X1 [Tribolium castaneum] 642918839 XM_008193387.1 255 2.41319e-128 PREDICTED: Tribolium castaneum breast carcinoma-amplified sequence 3 homolog (LOC661755), transcript variant X2, mRNA -- -- -- -- Q8SY41 1526 9.1e-168 Breast carcinoma-amplified sequence 3 homolog OS=Drosophila melanogaster GN=rudhira PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2109 WD40 repeat protein Cluster-8309.33921 BP_3 778.24 22.18 1983 642930944 XP_008196151.1 1847 8.7e-204 PREDICTED: protein diaphanous isoform X1 [Tribolium castaneum] -- -- -- -- -- K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 1365 2.8e-149 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF08586//PF11744//PF01207 RSC complex, Rsc14/Ldb7 subunit//Aluminium activated malate transporter//Dihydrouridine synthase (Dus) GO:0015743//GO:0055114//GO:0043044//GO:0008033 malate transport//oxidation-reduction process//ATP-dependent chromatin remodeling//tRNA processing GO:0017150//GO:0050660 tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding GO:0016586 RSC complex KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.33922 BP_3 292.46 7.77 2105 478260742 ENN80421.1 1508 1.9e-164 hypothetical protein YQE_03169, partial [Dendroctonus ponderosae] 642930947 XM_008197931.1 56 7.02996e-18 PREDICTED: Tribolium castaneum protein diaphanous (LOC660495), transcript variant X3, mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 749 7.9e-78 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF06367//PF06371//PF10508 Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain//Proteasome non-ATPase 26S subunit GO:0043248//GO:0016043//GO:0030036 proteasome assembly//cellular component organization//actin cytoskeleton organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1924 RhoA GTPase effector DIA/Diaphanous Cluster-8309.33924 BP_3 761.00 75.28 779 189234669 XP_001810780.1 281 1.3e-22 PREDICTED: uncharacterized protein LOC100141906 [Tribolium castaneum]>gi|270001601|gb|EEZ98048.1| hypothetical protein TcasGA2_TC000453 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33926 BP_3 38.71 2.76 968 270002885 EEZ99332.1 219 2.5e-15 serine protease P46 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33927 BP_3 86.00 9.86 712 170321839 BAG14264.1 488 1.2e-46 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P28175 274 3.2e-23 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33928 BP_3 4.00 150.97 212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33929 BP_3 14.00 3.93 463 642912278 XP_967486.2 179 5.3e-11 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07778 Mis6 GO:0034508 centromere complex assembly -- -- GO:0000776 kinetochore -- -- Cluster-8309.33930 BP_3 2893.87 104.38 1628 270010243 EFA06691.1 735 6.3e-75 hypothetical protein TcasGA2_TC009622 [Tribolium castaneum] -- -- -- -- -- K09250 CNBP cellular nucleic acid-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09250 Q8T8R1 419 1.1e-39 CCHC-type zinc finger protein CG3800 OS=Drosophila melanogaster GN=CG3800 PE=1 SV=1 PF00098//PF05733 Zinc knuckle//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0003676//GO:0003723//GO:0008270 nucleic acid binding//RNA binding//zinc ion binding GO:0019013 viral nucleocapsid KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.33931 BP_3 79.46 0.79 5157 91079020 XP_974879.1 3612 0.0e+00 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q5REU4 2079 1.2e-231 Staphylococcal nuclease domain-containing protein 1 OS=Pongo abelii GN=SND1 PE=2 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.33933 BP_3 478.09 12.57 2125 642923845 XP_008193902.1 1333 3.7e-144 PREDICTED: uncharacterized protein LOC662374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82198 175 2.9e-11 Transforming growth factor-beta-induced protein ig-h3 OS=Mus musculus GN=Tgfbi PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33934 BP_3 55.09 0.78 3704 642923758 XP_008193872.1 438 3.9e-40 PREDICTED: activating signal cointegrator 1 complex subunit 1-like [Tribolium castaneum]>gi|270006936|gb|EFA03384.1| hypothetical protein TcasGA2_TC013370 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLU6 316 2.3e-27 Succinate dehydrogenase assembly factor 4, mitochondrial OS=Drosophila melanogaster GN=Sirup PE=3 SV=2 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG2814 Transcription coactivator complex, P50 component (LigT RNA ligase/phosphodiesterase family) Cluster-8309.33935 BP_3 3.00 1.37 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33936 BP_3 310.72 2.47 6358 478251817 ENN72263.1 1263 1.5e-135 hypothetical protein YQE_11124, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 528 1.0e-51 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF02654 Sugar (and other) transporter//Major Facilitator Superfamily//Cobalamin-5-phosphate synthase GO:0055085//GO:0009236 transmembrane transport//cobalamin biosynthetic process GO:0008818//GO:0022857//GO:0051073 cobalamin 5'-phosphate synthase activity//transmembrane transporter activity//adenosylcobinamide-GDP ribazoletransferase activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33937 BP_3 164.19 1.13 7323 478251817 ENN72263.1 1262 2.2e-135 hypothetical protein YQE_11124, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 528 1.2e-51 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF02654//PF00083//PF07690 Cobalamin-5-phosphate synthase//Sugar (and other) transporter//Major Facilitator Superfamily GO:0009236//GO:0055085 cobalamin biosynthetic process//transmembrane transport GO:0008818//GO:0022857//GO:0051073 cobalamin 5'-phosphate synthase activity//transmembrane transporter activity//adenosylcobinamide-GDP ribazoletransferase activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33938 BP_3 46.59 0.36 6529 189241560 XP_001809966.1 2944 0.0e+00 PREDICTED: rab GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RAN1 1631 1.3e-179 Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1 PF14719//PF07776//PF00096//PF02892//PF13912//PF16622//PF13465//PF05443//PF00640 Phosphotyrosine interaction domain (PTB/PID)//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//Phosphotyrosine interaction domain (PTB/PID) GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046872//GO:0008270//GO:0003677 protein binding//metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.33939 BP_3 205.12 1.52 6783 642911031 XP_008193516.1 1571 3.0e-171 PREDICTED: cytoplasmic polyadenylation element-binding protein 2 [Tribolium castaneum] 462332955 APGK01039143.1 249 1.17936e-124 Dendroctonus ponderosae Seq01039153, whole genome shotgun sequence K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 Q9VSR3 737 6.3e-76 Probable RNA-binding protein orb2 OS=Drosophila melanogaster GN=orb2 PE=1 SV=1 PF00643//PF16367//PF00076 B-box zinc finger//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005622 intracellular KOG0129 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.3394 BP_3 64.47 0.59 5603 565660789 CDK37791.1 3344 0.0e+00 metabotropic GABA-B receptor subtype 1 [Periplaneta americana] 13160941 AF318272.1 279 2.04857e-141 AF318272 Drosophila melanogaster metabotropic GABA-B receptor subtype 1 (GABA-B-R1) mRNA, complete cds K04615 GABBR gamma-aminobutyric acid type B receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04615 Q9UBS5 2015 3.3e-224 Gamma-aminobutyric acid type B receptor subunit 1 OS=Homo sapiens GN=GABBR1 PE=1 SV=1 PF00003//PF01769 7 transmembrane sweet-taste receptor of 3 GCPR//Divalent cation transporter GO:0007186//GO:0006812 G-protein coupled receptor signaling pathway//cation transport GO:0004930//GO:0008324 G-protein coupled receptor activity//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1055 GABA-B ion channel receptor subunit GABABR1 and related subunits, G-protein coupled receptor superfamily Cluster-8309.33942 BP_3 249.94 3.85 3424 642938815 XP_008199930.1 763 7.5e-78 PREDICTED: uncharacterized protein LOC103314794 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-8309.33943 BP_3 1443.64 30.28 2590 91081545 XP_974976.1 1293 2.0e-139 PREDICTED: calumenin [Tribolium castaneum]>gi|270006175|gb|EFA02623.1| hypothetical protein TcasGA2_TC008343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDD8 880 6.3e-93 Calumenin OS=Pongo abelii GN=CALU PE=2 SV=1 PF13202//PF13499//PF08707//PF10591//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//Primase C terminal 2 (PriCT-2)//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.33945 BP_3 8.00 0.40 1262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33947 BP_3 839.00 54.19 1038 189237685 XP_969117.2 1150 3.0e-123 PREDICTED: proteasome subunit alpha type-7-1 [Tribolium castaneum]>gi|270007836|gb|EFA04284.1| hypothetical protein TcasGA2_TC014574 [Tribolium castaneum] 817185130 XM_012429758.1 219 8.34933e-109 PREDICTED: Orussus abietinus proteasome subunit alpha type-7 (LOC105702287), mRNA K02731 PSMA7 20S proteasome subunit alpha 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02731 P22769 985 1.7e-105 Proteasome subunit alpha type-7-1 OS=Drosophila melanogaster GN=Prosalpha4 PE=1 SV=2 PF10584//PF00227 Proteasome subunit A N-terminal signature//Proteasome subunit GO:0006511//GO:0051603 ubiquitin-dependent protein catabolic process//proteolysis involved in cellular protein catabolic process GO:0004175//GO:0004298 endopeptidase activity//threonine-type endopeptidase activity GO:0005634//GO:0005839//GO:0019773//GO:0005737 nucleus//proteasome core complex//proteasome core complex, alpha-subunit complex//cytoplasm KOG0183 20S proteasome, regulatory subunit alpha type PSMA7/PRE6 Cluster-8309.33948 BP_3 2.00 0.36 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33949 BP_3 3383.00 88.94 2125 478263440 ENN81801.1 2031 4.3e-225 hypothetical protein YQE_01807, partial [Dendroctonus ponderosae] 642913020 XM_008203132.1 388 0 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase pitchoune (LOC662696), mRNA K13179 DDX18, HAS1 ATP-dependent RNA helicase DDX18/HAS1 http://www.genome.jp/dbget-bin/www_bget?ko:K13179 Q9VD51 1856 3.5e-206 Probable ATP-dependent RNA helicase pitchoune OS=Drosophila melanogaster GN=pit PE=2 SV=2 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding -- -- KOG0342 ATP-dependent RNA helicase pitchoune Cluster-8309.3395 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13333 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.33950 BP_3 6916.72 67.16 5256 642927920 XP_008195448.1 2122 3.0e-235 PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927922|ref|XP_008195449.1| PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927924|ref|XP_974516.2| PREDICTED: dystroglycan [Tribolium castaneum] 642927923 XM_969423.3 68 3.78228e-24 PREDICTED: Tribolium castaneum dystroglycan (LOC663372), transcript variant X3, mRNA K06265 DAG1 dystroglycan 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06265 Q9TSZ6 506 3.0e-49 Dystroglycan OS=Canis familiaris GN=DAG1 PE=3 SV=1 PF03176//PF05454 MMPL family//Dystroglycan (Dystrophin-associated glycoprotein 1) GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016020//GO:0016010 membrane//dystrophin-associated glycoprotein complex KOG3781 Dystroglycan Cluster-8309.33951 BP_3 690.89 3.59 9565 642930211 XP_008196303.1 2766 1.1e-309 PREDICTED: protein aubergine [Tribolium castaneum]>gi|642930213|ref|XP_008196304.1| PREDICTED: protein aubergine [Tribolium castaneum]>gi|270010977|gb|EFA07425.1| piwi [Tribolium castaneum] 820846169 XM_003692874.2 149 6.47584e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 1682 2.3e-185 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF07859//PF09494//PF15384//PF01764//PF02186//PF02170//PF02230//PF02171//PF04636 alpha/beta hydrolase fold//Slx4 endonuclease//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//Lipase (class 3)//TFIIE beta subunit core domain//PAZ domain//Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin) GO:0006308//GO:1901031//GO:0006367//GO:0006260//GO:0006629//GO:0006281//GO:0006303//GO:0008152 DNA catabolic process//regulation of response to reactive oxygen species//transcription initiation from RNA polymerase II promoter//DNA replication//lipid metabolic process//DNA repair//double-strand break repair via nonhomologous end joining//metabolic process GO:0003676//GO:0005515//GO:0017108//GO:0016787 nucleic acid binding//protein binding//5'-flap endonuclease activity//hydrolase activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.33952 BP_3 584.36 7.47 4063 642933496 XP_974029.2 2621 3.2e-293 PREDICTED: rho GTPase-activating protein 20-like isoform X1 [Tribolium castaneum]>gi|642933498|ref|XP_008197442.1| PREDICTED: rho GTPase-activating protein 20-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2F6 386 1.9e-35 Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2 PF00788//PF00620 Ras association (RalGDS/AF-6) domain//RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.33953 BP_3 228.00 5.90 2155 642914709 XP_008199908.1 364 8.7e-32 PREDICTED: protein slit-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 180 7.7e-12 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF04159//PF13855//PF00560 NB glycoprotein//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.33954 BP_3 214.53 4.96 2377 642931392 XP_008196559.1 1015 3.1e-107 PREDICTED: paramyosin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33955 BP_3 29.35 0.38 4021 270003335 EEZ99782.1 1451 1.5e-157 hypothetical protein TcasGA2_TC002561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ERD6 793 1.2e-82 Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Mus musculus GN=Ralgps2 PE=1 SV=2 PF05767//PF00617//PF04636 Poxvirus virion envelope protein A14//RasGEF domain//PA26 p53-induced protein (sestrin) GO:0043087//GO:1901031//GO:0007264 regulation of GTPase activity//regulation of response to reactive oxygen species//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity GO:0005634//GO:0019031 nucleus//viral envelope KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.33956 BP_3 204.82 1.30 7883 270016265 EFA12711.1 933 3.3e-97 hypothetical protein TcasGA2_TC002345 [Tribolium castaneum] 642939045 XM_963847.3 205 3.95107e-100 PREDICTED: Tribolium castaneum palmitoyltransferase ZDHHC5 (LOC657384), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33957 BP_3 175.55 4.15 2329 549438543 AGX25160.1 1034 1.9e-109 cathepsin B precursor [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P90850 544 5.2e-54 Uncharacterized peptidase C1-like protein F26E4.3 OS=Caenorhabditis elegans GN=F26E4.3 PE=1 SV=3 PF01033//PF00112//PF03051 Somatomedin B domain//Papain family cysteine protease//Peptidase C1-like family GO:0007165//GO:0006508//GO:0006955 signal transduction//proteolysis//immune response GO:0008234//GO:0005044//GO:0030247//GO:0004197 cysteine-type peptidase activity//scavenger receptor activity//polysaccharide binding//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.33958 BP_3 29.81 0.61 2654 478252022 ENN72453.1 1291 3.4e-139 hypothetical protein YQE_10796, partial [Dendroctonus ponderosae] -- -- -- -- -- K10838 XPC xeroderma pigmentosum group C-complementing protein http://www.genome.jp/dbget-bin/www_bget?ko:K10838 Q24595 1054 4.3e-113 DNA repair protein complementing XP-C cells homolog OS=Drosophila melanogaster GN=mus210 PE=1 SV=2 PF08070//PF10405 DTHCT (NUC029) region//Rad4 beta-hairpin domain 3 GO:0006265 DNA topological change GO:0003918//GO:0005524//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding//DNA binding GO:0005634 nucleus KOG2179 Nucleotide excision repair complex XPC-HR23B, subunit XPC/DPB11 Cluster-8309.33959 BP_3 840.06 17.62 2590 91082539 XP_973726.1 2206 2.7e-245 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 839 3.6e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF03357//PF08496//PF06905//PF11965 Snf7//Peptidase family S49 N-terminal//Fas apoptotic inhibitory molecule (FAIM1)//Domain of unknown function (DUF3479) GO:0015994//GO:0007034//GO:0043066 chlorophyll metabolic process//vacuolar transport//negative regulation of apoptotic process GO:0016851//GO:0004252 magnesium chelatase activity//serine-type endopeptidase activity GO:0005886//GO:0010007 plasma membrane//magnesium chelatase complex -- -- Cluster-8309.3396 BP_3 1.00 0.40 411 189235363 XP_001808147.1 237 8.8e-18 PREDICTED: uncharacterized protein LOC100142009 [Tribolium castaneum]>gi|270003618|gb|EFA00066.1| hypothetical protein TcasGA2_TC002880 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33960 BP_3 268.10 4.89 2936 642915507 XP_008190646.1 500 2.0e-47 PREDICTED: suppressor of cytokine signaling 6 [Tribolium castaneum]>gi|270004015|gb|EFA00463.1| hypothetical protein TcasGA2_TC003320 [Tribolium castaneum] -- -- -- -- -- K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q9JLY0 390 4.7e-36 Suppressor of cytokine signaling 6 OS=Mus musculus GN=Socs6 PE=1 SV=2 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.33961 BP_3 33.45 0.36 4752 642918534 XP_008191512.1 3217 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7P4 637 1.7e-64 SEC14 domain and spectrin repeat-containing protein 1 OS=Xenopus tropicalis GN=sestd1 PE=2 SV=1 PF00435//PF00260//PF00536 Spectrin repeat//Protamine P1//SAM domain (Sterile alpha motif) GO:0007283 spermatogenesis GO:0003677//GO:0005515 DNA binding//protein binding GO:0000786//GO:0005634 nucleosome//nucleus KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.33963 BP_3 630.00 16.24 2162 642938245 XP_008198127.1 1026 1.5e-108 PREDICTED: chromatin assembly factor 1 subunit A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JMK9 309 8.5e-27 Chromatin assembly factor 1 subunit A OS=Danio rerio GN=chaf1a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4364 Chromatin assembly factor-I Cluster-8309.33964 BP_3 601.35 4.60 6591 642938247 XP_008198128.1 1652 1.2e-180 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 405 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 1386 3.4e-151 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF17096//PF02932//PF05445//PF06553//PF03293//PF07714//PF01080//PF00069 Altered inheritance of mitochondria protein 3//Neurotransmitter-gated ion-channel transmembrane region//Poxvirus serine/threonine protein kinase//BNIP3//Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Protein tyrosine kinase//Presenilin//Protein kinase domain GO:0006144//GO:0006351//GO:0006811//GO:0051016//GO:0006206//GO:0006468//GO:0019083//GO:0043065 purine nucleobase metabolic process//transcription, DNA-templated//ion transport//barbed-end actin filament capping//pyrimidine nucleobase metabolic process//protein phosphorylation//viral transcription//positive regulation of apoptotic process GO:0004190//GO:0003677//GO:0004672//GO:0005524//GO:0003899 aspartic-type endopeptidase activity//DNA binding//protein kinase activity//ATP binding//DNA-directed RNA polymerase activity GO:0016020//GO:0030479//GO:0016021//GO:0005730//GO:0005740 membrane//actin cortical patch//integral component of membrane//nucleolus//mitochondrial envelope KOG0671 LAMMER dual specificity kinases Cluster-8309.33965 BP_3 1599.26 17.69 4648 642926401 XP_008191947.1 3150 0.0e+00 PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|642926403|ref|XP_008191948.1| PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|270009223|gb|EFA05671.1| hormone receptor in 39-like protein [Tribolium castaneum] 642926402 XM_008193726.1 635 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 beta (LOC658947), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 Q05192 1612 1.5e-177 Nuclear hormone receptor FTZ-F1 beta OS=Drosophila melanogaster GN=Hr39 PE=1 SV=3 PF03846//PF00105//PF00104 Cell division inhibitor SulA//Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0051782//GO:0006355//GO:0009432//GO:0007165 steroid hormone mediated signaling pathway//negative regulation of cell division//regulation of transcription, DNA-templated//SOS response//signal transduction GO:0043565//GO:0008270//GO:0003700//GO:0046872//GO:0003707 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//steroid hormone receptor activity GO:0005634//GO:0009276//GO:0005667 nucleus//Gram-negative-bacterium-type cell wall//transcription factor complex -- -- Cluster-8309.33966 BP_3 141.90 1.94 3815 571533289 XP_006561360.1 595 2.5e-58 PREDICTED: uncharacterized protein LOC725964 isoform X1 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88281 393 2.7e-36 Multiple epidermal growth factor-like domains protein 6 OS=Rattus norvegicus GN=Megf6 PE=1 SV=1 PF02793//PF07645 Hormone receptor domain//Calcium-binding EGF domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005509 G-protein coupled receptor activity//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.33967 BP_3 33.13 0.44 3961 270006563 EFA03011.1 2199 2.6e-244 hypothetical protein TcasGA2_TC010434 [Tribolium castaneum] 768439826 XM_011563263.1 40 1.04481e-08 PREDICTED: Plutella xylostella probable multidrug resistance-associated protein lethal(2)03659 (LOC105391726), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1104 1.0e-118 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF13304//PF00664//PF01637 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Archaeal ATPase GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.33968 BP_3 13.00 1.29 776 751233858 XP_011170631.1 330 2.7e-28 PREDICTED: uncharacterized protein LOC105203526 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33969 BP_3 2296.00 61.99 2077 642926440 XP_972024.2 378 2.0e-33 PREDICTED: eukaryotic translation initiation factor 4H [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WUK2 275 7.2e-23 Eukaryotic translation initiation factor 4H OS=Mus musculus GN=Eif4h PE=1 SV=3 PF00076//PF05432 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Bone sialoprotein II (BSP-II) GO:0001503//GO:0007155 ossification//cell adhesion GO:0003676 nucleic acid binding GO:0005576 extracellular region KOG0118 FOG: RRM domain Cluster-8309.3397 BP_3 80.48 2.44 1880 642933166 XP_008197284.1 1918 4.8e-212 PREDICTED: hexosaminidase D-like [Tribolium castaneum]>gi|270012547|gb|EFA08995.1| hypothetical protein TcasGA2_TC006702 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 680 7.1e-70 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- -- -- Cluster-8309.33970 BP_3 456.86 13.17 1964 478255591 ENN75805.1 2200 1.0e-244 hypothetical protein YQE_07641, partial [Dendroctonus ponderosae]>gi|546682293|gb|ERL92251.1| hypothetical protein D910_09568 [Dendroctonus ponderosae] 704290140 XM_010177591.1 138 1.70909e-63 PREDICTED: Caprimulgus carolinensis SNW domain containing 1 (SNW1), partial mRNA K06063 SNW1, SKIIP, SKIP SNW domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06063 P39736 1642 2.1e-181 Puff-specific protein Bx42 OS=Drosophila melanogaster GN=Bx42 PE=1 SV=1 PF02731//PF02841 SKIP/SNW domain//Guanylate-binding protein, C-terminal domain GO:0000398 mRNA splicing, via spliceosome GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005681 spliceosomal complex KOG2441 mRNA splicing factor/probable chromatin binding snw family nuclear protein Cluster-8309.33973 BP_3 504.72 15.04 1909 478256415 ENN76602.1 1537 7.4e-168 hypothetical protein YQE_06860, partial [Dendroctonus ponderosae]>gi|546677585|gb|ERL88390.1| hypothetical protein D910_05776 [Dendroctonus ponderosae] -- -- -- -- -- K04427 MAP3K7, TAK1 mitogen-activated protein kinase kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04427 Q5RFL3 896 6.5e-95 Mitogen-activated protein kinase kinase kinase 7 OS=Pongo abelii GN=MAP3K7 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0192 Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs Cluster-8309.33974 BP_3 184.76 4.87 2122 642915291 XP_008190557.1 1402 3.7e-152 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 656 4.8e-67 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.33975 BP_3 1053.00 62.87 1099 332374658 AEE62470.1 853 8.8e-89 unknown [Dendroctonus ponderosae]>gi|478259682|gb|ENN79526.1| hypothetical protein YQE_03989, partial [Dendroctonus ponderosae]>gi|546682953|gb|ERL92832.1| hypothetical protein D910_10140 [Dendroctonus ponderosae] 346708051 AK378343.1 163 1.19535e-77 Bombyx mori mRNA, clone: fmgV32H08 K12197 CHMP1, VPS46, DID2 charged multivesicular body protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12197 Q5ZKX1 645 4.7e-66 Charged multivesicular body protein 1b OS=Gallus gallus GN=CHMP1B PE=2 SV=1 PF13413//PF03357//PF00443 Helix-turn-helix domain//Snf7//Ubiquitin carboxyl-terminal hydrolase GO:0007034//GO:0016579 vacuolar transport//protein deubiquitination GO:0036459//GO:0003677 ubiquitinyl hydrolase activity//DNA binding -- -- KOG3232 Vacuolar assembly/sorting protein DID2 Cluster-8309.33976 BP_3 35759.54 1964.73 1169 158562474 ABW74143.1 489 1.5e-46 cuticular protein Ld-CP3 [Leptinotarsa decemlineata] 766935802 XM_011501981.1 36 5.05283e-07 PREDICTED: Ceratosolen solmsi marchali endocuticle structural glycoprotein SgAbd-8-like (LOC105364117), mRNA -- -- -- -- Q7M4F3 319 3.2e-28 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.33978 BP_3 2413.86 41.74 3079 642932474 XP_008197131.1 1327 2.7e-143 PREDICTED: uncharacterized protein LOC662025 isoform X1 [Tribolium castaneum] 642932473 XM_008198909.1 261 1.13573e-131 PREDICTED: Tribolium castaneum uncharacterized LOC662025 (LOC662025), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33979 BP_3 12.98 0.62 1307 189239912 XP_971042.2 392 3.0e-35 PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|642931218|ref|XP_008196488.1| PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|270012116|gb|EFA08564.1| hypothetical protein TcasGA2_TC006219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQT7 256 7.2e-21 Desumoylating isopeptidase 1 OS=Mus musculus GN=Desi1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.3398 BP_3 5.00 0.53 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33980 BP_3 910.00 36.09 1507 478256232 ENN76426.1 1870 1.4e-206 hypothetical protein YQE_07087, partial [Dendroctonus ponderosae]>gi|478268074|gb|ENN83141.1| hypothetical protein YQE_00495, partial [Dendroctonus ponderosae]>gi|546684450|gb|ERL94089.1| hypothetical protein D910_11371 [Dendroctonus ponderosae] -- -- -- -- -- K16575 ACTR1, ARP1 centractin http://www.genome.jp/dbget-bin/www_bget?ko:K16575 Q8R5C5 1676 1.8e-185 Beta-centractin OS=Mus musculus GN=Actr1b PE=1 SV=1 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.33982 BP_3 1511.00 95.54 1054 91077414 XP_975386.1 1035 6.6e-110 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 551522690 XM_005812776.1 214 5.10508e-106 PREDICTED: Xiphophorus maculatus stress-70 protein, mitochondrial-like (LOC102235937), mRNA K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 Q5ZM98 945 7.4e-101 Stress-70 protein, mitochondrial OS=Gallus gallus GN=HSPA9 PE=1 SV=1 -- -- GO:0006457 protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding -- -- KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.33983 BP_3 597.56 16.13 2077 755943442 XP_011299119.1 935 5.1e-98 PREDICTED: 14-3-3 protein zeta isoform X2 [Fopius arisanus] 642911747 XM_008202503.1 179 2.92223e-86 PREDICTED: Tribolium castaneum 14-3-3 protein zeta (LOC660150), mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 878 8.6e-93 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 PF05823//PF02154 Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Flagellar motor switch protein FliM GO:0071973 bacterial-type flagellum-dependent cell motility GO:0008289//GO:0003774 lipid binding//motor activity GO:0009425 bacterial-type flagellum basal body -- -- Cluster-8309.33984 BP_3 306.61 14.91 1283 642923427 XP_008193740.1 1291 1.7e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUQ0 385 7.8e-36 Clavesin-1 OS=Homo sapiens GN=CLVS1 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.33985 BP_3 1171.77 48.30 1461 642939156 XP_008200359.1 1798 3.1e-198 PREDICTED: host cell factor 2 isoform X1 [Tribolium castaneum] 642939157 XM_964209.2 291 1.12027e-148 PREDICTED: Tribolium castaneum host cell factor 2 (LOC657767), transcript variant X2, mRNA K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q61191 1463 8.8e-161 Host cell factor 1 OS=Mus musculus GN=Hcfc1 PE=1 SV=2 PF07646//PF01344 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.33986 BP_3 8.23 0.32 1520 642939156 XP_008200359.1 1263 3.5e-136 PREDICTED: host cell factor 2 isoform X1 [Tribolium castaneum] 642939157 XM_964209.2 139 3.65816e-64 PREDICTED: Tribolium castaneum host cell factor 2 (LOC657767), transcript variant X2, mRNA K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q61191 1005 1.2e-107 Host cell factor 1 OS=Mus musculus GN=Hcfc1 PE=1 SV=2 PF01344//PF07646 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.33987 BP_3 769.71 11.66 3474 91094425 XP_969302.1 2010 1.9e-222 PREDICTED: host cell factor 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q9V4C8 647 8.8e-66 Host cell factor OS=Drosophila melanogaster GN=Hcf PE=1 SV=2 PF11722//PF00041//PF16656 CCCH zinc finger in TRM13 protein//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0008168//GO:0003993//GO:0046872//GO:0005515 methyltransferase activity//acid phosphatase activity//metal ion binding//protein binding -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.33988 BP_3 69.93 1.55 2460 91094425 XP_969302.1 1411 3.9e-153 PREDICTED: host cell factor 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q61191 443 2.8e-42 Host cell factor 1 OS=Mus musculus GN=Hcfc1 PE=1 SV=2 PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.33989 BP_3 148.98 1.31 5781 478253875 ENN74167.1 2124 1.9e-235 hypothetical protein YQE_09140, partial [Dendroctonus ponderosae] 642911731 XM_008202495.1 40 1.52928e-08 PREDICTED: Tribolium castaneum uncharacterized LOC660279 (LOC660279), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33990 BP_3 60.84 0.61 5128 642927623 XP_008195338.1 1388 3.8e-150 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] 560970175 XM_006207391.1 80 7.87423e-31 PREDICTED: Vicugna pacos BTB (POZ) domain containing 3 (BTBD3), transcript variant X2, mRNA K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 1014 3.6e-108 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF00651//PF10501 BTB/POZ domain//Ribosomal subunit 39S -- -- GO:0005515 protein binding GO:0005739 mitochondrion KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.33993 BP_3 3834.26 54.10 3708 91094023 XP_967468.1 757 4.0e-77 PREDICTED: protein BTG1-like [Tribolium castaneum] 642915766 XM_962375.2 127 4.23708e-57 PREDICTED: Tribolium castaneum protein BTG1-like (LOC655815), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 P50615 292 1.4e-24 Protein BTG3 OS=Mus musculus GN=Btg3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33996 BP_3 374.00 10.06 2084 642933476 XP_008197433.1 1033 2.2e-109 PREDICTED: cytochrome P450 9e2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q964T2 774 9.9e-81 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.33998 BP_3 124.00 14.36 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33999 BP_3 7537.63 45.58 8263 156481746 ABU68466.1 2057 1.6e-227 laccase 2 [Monochamus alternatus] 156481745 EU093075.1 794 0 Monochamus alternatus laccase 2 mRNA, complete cds -- -- -- -- Q99056 454 5.0e-43 Laccase-5 OS=Trametes villosa GN=LCC5 PE=3 SV=2 PF07732//PF00394//PF07731 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- KOG1263 Multicopper oxidases Cluster-8309.34 BP_3 4.00 0.86 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.340 BP_3 4.00 0.58 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34000 BP_3 13922.36 90.17 7734 156481746 ABU68466.1 2057 1.5e-227 laccase 2 [Monochamus alternatus] 156481745 EU093075.1 794 0 Monochamus alternatus laccase 2 mRNA, complete cds -- -- -- -- Q99056 454 4.7e-43 Laccase-5 OS=Trametes villosa GN=LCC5 PE=3 SV=2 PF07731//PF00394//PF07732 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0005507//GO:0016491 copper ion binding//oxidoreductase activity -- -- KOG1263 Multicopper oxidases Cluster-8309.34001 BP_3 176.21 3.17 2968 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34002 BP_3 46.48 2.64 1141 820805582 AKG92782.1 561 6.6e-55 Pxs [Leptinotarsa decemlineata] 543263651 XM_005422191.1 85 2.84613e-34 PREDICTED: Geospiza fortis transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA K09070 TCF15, PARAXIS transcription factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09070 Q60539 292 4.2e-25 Transcription factor 15 OS=Mesocricetus auratus GN=TCF15 PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.34004 BP_3 1826.43 31.11 3121 642912272 XP_008200632.1 945 5.3e-99 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 7.7e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF01414//PF00089 Delta serrate ligand//Trypsin GO:0007154//GO:0006508 cell communication//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.34005 BP_3 1250.44 52.86 1432 751447415 XP_011177845.1 246 2.8e-18 PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751447417|ref|XP_011177846.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751797807|ref|XP_011208789.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera dorsalis] -- -- -- -- -- K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P00430 136 6.5e-07 Cytochrome c oxidase subunit 7C, mitochondrial OS=Bos taurus GN=COX7C PE=1 SV=3 PF02935 Cytochrome c oxidase subunit VIIc GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.34006 BP_3 33.94 0.96 1994 91085815 XP_974770.1 279 5.8e-22 PREDICTED: maternal protein exuperantia-1 [Tribolium castaneum]>gi|270011046|gb|EFA07494.1| exuperantia [Tribolium castaneum] -- -- -- -- -- K18745 EXU maternal protein exuperantia http://www.genome.jp/dbget-bin/www_bget?ko:K18745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34007 BP_3 6.00 0.58 788 255522801 NP_001157313.1 199 4.3e-13 longitudinals lacking isoform 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF13912//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.34011 BP_3 1060.82 8.52 6293 189239910 XP_001811161.1 2656 4.3e-297 PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|642931213|ref|XP_008196486.1| PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|270012115|gb|EFA08563.1| hypothetical protein TcasGA2_TC006218 [Tribolium castaneum] 642931212 XM_008198264.1 80 9.67119e-31 PREDICTED: Tribolium castaneum uncharacterized LOC100142394 (LOC100142394), transcript variant X2, mRNA -- -- -- -- P91791 286 1.2e-23 Peptidyl-prolyl cis-trans isomerase OS=Hemicentrotus pulcherrimus PE=2 SV=1 PF00097//PF01363//PF00643//PF14634//PF13639//PF00160 Zinc finger, C3HC4 type (RING finger)//FYVE zinc finger//B-box zinc finger//zinc-RING finger domain//Ring finger domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0008270//GO:0003755//GO:0005515//GO:0046872 zinc ion binding//peptidyl-prolyl cis-trans isomerase activity//protein binding//metal ion binding GO:0005622 intracellular KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.34012 BP_3 210.02 4.94 2342 642938126 XP_969076.2 1038 6.6e-110 PREDICTED: inositol monophosphatase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 P20456 674 4.4e-69 Inositol monophosphatase 1 OS=Bos taurus GN=IMPA1 PE=1 SV=1 PF02399//PF00459 Origin of replication binding protein//Inositol monophosphatase family GO:0046854//GO:0006260 phosphatidylinositol phosphorylation//DNA replication GO:0003688//GO:0005524 DNA replication origin binding//ATP binding GO:0046809 replication compartment KOG2951 Inositol monophosphatase Cluster-8309.34014 BP_3 723.41 23.63 1767 383855940 XP_003703468.1 637 1.6e-63 PREDICTED: trypsin 3A1-like isoform X3 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q27081 352 7.2e-32 Clotting factor B OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34017 BP_3 506.24 89.27 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34018 BP_3 305.72 2.56 6043 827549501 XP_012546855.1 724 4.4e-73 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.8e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.3402 BP_3 17.75 0.90 1244 642936663 XP_008198528.1 726 5.3e-74 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10859 ALKBH2 alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10859 Q6P6J4 550 5.6e-55 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 OS=Mus musculus GN=Alkbh2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34020 BP_3 294.36 20.89 971 642928426 XP_971688.3 700 4.3e-71 PREDICTED: RRP15-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VFE6 418 8.8e-40 RRP15-like protein OS=Drosophila melanogaster GN=CG3817 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2974 Uncharacterized conserved protein Cluster-8309.34022 BP_3 32.00 5.56 569 -- -- -- -- -- 403311088 JX457150.1 551 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34023 BP_3 28.08 0.50 2999 91094851 XP_972051.1 2107 9.3e-234 PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating [Tribolium castaneum]>gi|270006577|gb|EFA03025.1| hypothetical protein TcasGA2_TC010448 [Tribolium castaneum] 808352053 KR024162.1 90 1.26498e-36 Drosophila melanogaster strain ZK398 ph-p-RA (ph-p) gene, partial sequence; CG3835 (CG3835) and Pgd (Pgd) genes, complete cds, alternatively spliced; bcn92-RA (bcn92) gene, complete cds; wapl (wapl) and Cyp4d1 (Cyp4d1) genes, complete cds, alternatively spliced; and CG3630-RD (CG3630) gene, partial sequence K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00033 P41570 1725 7.6e-191 6-phosphogluconate dehydrogenase, decarboxylating OS=Ceratitis capitata GN=Pgd PE=2 SV=1 PF03446//PF14833//PF00393 NAD binding domain of 6-phosphogluconate dehydrogenase//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//6-phosphogluconate dehydrogenase, C-terminal domain GO:0006098//GO:0019521//GO:0055114 pentose-phosphate shunt//D-gluconate metabolic process//oxidation-reduction process GO:0004616//GO:0050661//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//NADP binding//NAD binding -- -- KOG2653 6-phosphogluconate dehydrogenase Cluster-8309.34024 BP_3 77.07 1.23 3317 577754854 AHH86056.1 1979 7.2e-219 glycoside hydrolase family 31 [Phaedon cochleariae] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 875 3.1e-92 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.34027 BP_3 4055.59 47.71 4389 91080259 XP_973356.1 2901 0.0e+00 PREDICTED: TBC1 domain family member 23 [Tribolium castaneum]>gi|270005620|gb|EFA02068.1| hypothetical protein TcasGA2_TC007702 [Tribolium castaneum] 641791443 XM_005305637.2 106 2.37022e-45 PREDICTED: Chrysemys picta bellii chaperonin containing TCP1, subunit 4 (delta) (CCT4), mRNA K09496 CCT4 T-complex protein 1 subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K09496 Q9NB32 2088 9.0e-233 T-complex protein 1 subunit delta OS=Ochlerotatus triseriatus PE=2 SV=1 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding GO:0005622 intracellular KOG0358 Chaperonin complex component, TCP-1 delta subunit (CCT4) Cluster-8309.34028 BP_3 246.43 2.89 4403 642932431 XP_008197110.1 2076 5.4e-230 PREDICTED: uncharacterized protein LOC100141760 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34030 BP_3 110.46 2.94 2104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34032 BP_3 28.00 1.49 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34036 BP_3 578.82 1.52 18694 642929802 XP_008195983.1 15974 0.0e+00 PREDICTED: dynein heavy chain, cytoplasmic isoform X2 [Tribolium castaneum] 642929801 XM_008197761.1 2865 0 PREDICTED: Tribolium castaneum dynein heavy chain (LOC664489), transcript variant X2, mRNA K10413 DYNC1H dynein heavy chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10413 P37276 14248 0.0e+00 Dynein heavy chain, cytoplasmic OS=Drosophila melanogaster GN=Dhc64C PE=2 SV=2 PF01695//PF07728//PF04111//PF05791//PF00004//PF02932//PF10473//PF01031//PF01580//PF07851//PF13851//PF00437//PF01496//PF05529//PF14943//PF07926//PF07168//PF03938//PF00910//PF06156//PF05073//PF06160//PF06008//PF05496//PF06009//PF12106//PF03028//PF06810//PF03767//PF00005//PF04513//PF08702 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Autophagy protein Apg6//Bacillus haemolytic enterotoxin (HBL)//ATPase family associated with various cellular activities (AAA)//Neurotransmitter-gated ion-channel transmembrane region//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Dynamin central region//FtsK/SpoIIIE family//TMPIT-like protein//Growth-arrest specific micro-tubule binding//Type II/IV secretion system protein//V-type ATPase 116kDa subunit family//B-cell receptor-associated protein 31-like//Mitochondrial ribosome subunit S26//TPR/MLP1/MLP2-like protein//Ureide permease//Outer membrane protein (OmpH-like)//RNA helicase//Protein of unknown function (DUF972)//Baculovirus P24 capsid protein//Septation ring formation regulator, EzrA//Laminin Domain I//Holliday junction DNA helicase ruvB N-terminus//Laminin Domain II//Colicin C terminal ribonuclease domain//Dynein heavy chain and region D6 of dynein motor//Phage minor structural protein GP20//HAD superfamily, subfamily IIIB (Acid phosphatase)//ABC transporter//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family GO:0007017//GO:0051252//GO:0007018//GO:0030334//GO:0007165//GO:0009405//GO:0006914//GO:0051258//GO:0006810//GO:0006281//GO:0006886//GO:0007155//GO:0030155//GO:0006811//GO:0071705//GO:0015991//GO:0006606//GO:0006260//GO:0015992//GO:0045995//GO:0019497//GO:0006310//GO:0030168//GO:0006771//GO:0048870//GO:0000921 microtubule-based process//regulation of RNA metabolic process//microtubule-based movement//regulation of cell migration//signal transduction//pathogenesis//autophagy//protein polymerization//transport//DNA repair//intracellular protein transport//cell adhesion//regulation of cell adhesion//ion transport//nitrogen compound transport//ATP hydrolysis coupled proton transport//protein import into nucleus//DNA replication//proton transport//regulation of embryonic development//hexachlorocyclohexane metabolic process//DNA recombination//platelet activation//riboflavin metabolic process//cell motility//septin ring assembly GO:0000166//GO:0015078//GO:0005198//GO:0004540//GO:0005525//GO:0042803//GO:0009378//GO:0003724//GO:0003723//GO:0003677//GO:0051082//GO:0003993//GO:0016887//GO:0005102//GO:0005524//GO:0045502//GO:0008134//GO:0030674//GO:0003777 nucleotide binding//hydrogen ion transmembrane transporter activity//structural molecule activity//ribonuclease activity//GTP binding//protein homodimerization activity//four-way junction helicase activity//RNA helicase activity//RNA binding//DNA binding//unfolded protein binding//acid phosphatase activity//ATPase activity//receptor binding//ATP binding//dynein binding//transcription factor binding//protein binding, bridging//microtubule motor activity GO:0016021//GO:0009379//GO:0031514//GO:0005940//GO:0016020//GO:0033179//GO:0005657//GO:0005763//GO:0005783//GO:0005874//GO:0019031//GO:0005577//GO:0019028//GO:0030286//GO:0005667 integral component of membrane//Holliday junction helicase complex//motile cilium//septin ring//membrane//proton-transporting V-type ATPase, V0 domain//replication fork//mitochondrial small ribosomal subunit//endoplasmic reticulum//microtubule//viral envelope//fibrinogen complex//viral capsid//dynein complex//transcription factor complex KOG3595 Dyneins, heavy chain Cluster-8309.3404 BP_3 6.00 0.43 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34040 BP_3 1.00 0.69 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34045 BP_3 2448.38 54.15 2471 478255194 ENN75423.1 2734 1.5e-306 hypothetical protein YQE_07974, partial [Dendroctonus ponderosae] 759182915 XM_011381699.1 369 0 PREDICTED: Pteropus vampyrus protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant X1, mRNA K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 Q76MZ3 2356 4.2e-264 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus GN=Ppp2r1a PE=1 SV=3 PF02985//PF01602 HEAT repeat//Adaptin N terminal region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.34046 BP_3 29.71 0.57 2824 91077036 XP_967646.1 794 1.6e-81 PREDICTED: molybdenum cofactor sulfurase 1 [Tribolium castaneum]>gi|270001749|gb|EEZ98196.1| hypothetical protein TcasGA2_TC000626 [Tribolium castaneum] -- -- -- -- -- K15631 ABA3 molybdenum cofactor sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15631 Q8IU29 599 2.6e-60 Molybdenum cofactor sulfurase OS=Bombyx mori GN=mal PE=2 SV=1 PF01082//PF03473 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//MOSC domain GO:0055114 oxidation-reduction process GO:0003824//GO:0005507//GO:0030170//GO:0004497//GO:0016715//GO:0030151 catalytic activity//copper ion binding//pyridoxal phosphate binding//monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//molybdenum ion binding -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.34047 BP_3 379.25 6.26 3213 91077036 XP_967646.1 1648 1.7e-180 PREDICTED: molybdenum cofactor sulfurase 1 [Tribolium castaneum]>gi|270001749|gb|EEZ98196.1| hypothetical protein TcasGA2_TC000626 [Tribolium castaneum] -- -- -- -- -- K15631 ABA3 molybdenum cofactor sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15631 Q8IU29 1184 4.4e-128 Molybdenum cofactor sulfurase OS=Bombyx mori GN=mal PE=2 SV=1 PF01082//PF00779//PF03473 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//BTK motif//MOSC domain GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0016715//GO:0003824//GO:0005507//GO:0030170//GO:0004497//GO:0030151 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//catalytic activity//copper ion binding//pyridoxal phosphate binding//monooxygenase activity//molybdenum ion binding -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.34048 BP_3 134.90 1.68 4152 270015509 EFA11957.1 1503 1.4e-163 serine protease H82 [Tribolium castaneum] 641658676 XM_001951259.3 168 7.67122e-80 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- Q96EN8 486 4.9e-47 Molybdenum cofactor sulfurase OS=Homo sapiens GN=MOCOS PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34049 BP_3 24.00 5.39 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34053 BP_3 1023.39 16.33 3312 642930597 XP_008198288.1 3539 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 35 isoform X1 [Tribolium castaneum] 874486365 XM_013103861.1 127 3.78014e-57 PREDICTED: Anas platyrhynchos VPS35 retromer complex component (VPS35), transcript variant X2, mRNA K18468 VPS35 vacuolar protein sorting-associated protein 35 http://www.genome.jp/dbget-bin/www_bget?ko:K18468 Q2HJG5 2694 3.6e-303 Vacuolar protein sorting-associated protein 35 OS=Bos taurus GN=VPS35 PE=2 SV=1 PF03635 Vacuolar protein sorting-associated protein 35 GO:0042147//GO:0015031 retrograde transport, endosome to Golgi//protein transport GO:0008565 protein transporter activity GO:0030904 retromer complex KOG1107 Membrane coat complex Retromer, subunit VPS35 Cluster-8309.34054 BP_3 168.00 14.38 855 642914652 XP_973930.2 663 7.3e-67 PREDICTED: protein DPCD [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5D8N2 414 2.2e-39 Protein DPCD OS=Xenopus laevis GN=dpcd PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34055 BP_3 242.00 9.18 1563 478263634 ENN81940.1 1413 1.4e-153 hypothetical protein YQE_01651, partial [Dendroctonus ponderosae]>gi|546672370|gb|ERL84269.1| hypothetical protein D910_01650 [Dendroctonus ponderosae]>gi|546682305|gb|ERL92258.1| hypothetical protein D910_09575 [Dendroctonus ponderosae] -- -- -- -- -- K14793 RRP9 ribosomal RNA-processing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14793 O43818 871 4.2e-92 U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens GN=RRP9 PE=1 SV=1 PF00400//PF01621 WD domain, G-beta repeat//Cell fusion glycoprotein K -- -- GO:0005515 protein binding GO:0016020 membrane KOG0299 U3 snoRNP-associated protein (contains WD40 repeats) Cluster-8309.34056 BP_3 26.00 1.38 1197 91090912 XP_973979.1 222 1.4e-15 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47948 199 2.7e-14 Troponin C, isoform 2 OS=Drosophila melanogaster GN=TpnC47D PE=2 SV=2 PF13833//PF13405//PF00036//PF13499//PF13202 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.34057 BP_3 159.68 1.50 5439 642921494 XP_968130.3 3788 0.0e+00 PREDICTED: uncharacterized protein LOC656511 [Tribolium castaneum]>gi|270006226|gb|EFA02674.1| hypothetical protein TcasGA2_TC008395 [Tribolium castaneum] 642921493 XM_963037.3 224 7.46098e-111 PREDICTED: Tribolium castaneum uncharacterized LOC656511 (LOC656511), mRNA -- -- -- -- O43182 480 3.2e-46 Rho GTPase-activating protein 6 OS=Homo sapiens GN=ARHGAP6 PE=1 SV=3 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG2710 Rho GTPase-activating protein Cluster-8309.34058 BP_3 16.39 0.87 1203 353231251 CCD77669.1 928 1.9e-97 putative ubiquitin (ribosomal protein L40) [Schistosoma mansoni] 260830118 XM_002609963.1 308 3.25385e-158 Branchiostoma floridae hypothetical protein, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 923 3.0e-98 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF04452//PF14560//PF00240 RNA methyltransferase//Ubiquitin-like domain//Ubiquitin family GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.34061 BP_3 5.00 1.13 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34065 BP_3 1210.38 22.85 2845 642930858 XP_008196115.1 2856 0.0e+00 PREDICTED: oxysterol-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270012012|gb|EFA08460.1| hypothetical protein TcasGA2_TC006108 [Tribolium castaneum] 642930857 XM_008197893.1 257 1.75434e-129 PREDICTED: Tribolium castaneum oxysterol-binding protein 1 (LOC657071), transcript variant X1, mRNA -- -- -- -- P22059 1707 8.8e-189 Oxysterol-binding protein 1 OS=Homo sapiens GN=OSBP PE=1 SV=1 PF02371//PF05854 Transposase IS116/IS110/IS902 family//Non-histone chromosomal protein MC1 GO:0042262//GO:0006313 DNA protection//transposition, DNA-mediated GO:0003677//GO:0005543//GO:0004803 DNA binding//phospholipid binding//transposase activity -- -- KOG1737 Oxysterol-binding protein Cluster-8309.34067 BP_3 864.69 5.66 7661 189236457 XP_973878.2 4529 0.0e+00 PREDICTED: UHRF1-binding protein 1-like isoform X2 [Tribolium castaneum]>gi|270005939|gb|EFA02387.1| hypothetical protein TcasGA2_TC008067 [Tribolium castaneum] 507533084 XM_004650550.1 41 5.64088e-09 PREDICTED: Jaculus jaculus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA -- -- -- -- A0JNW5 989 4.3e-105 UHRF1-binding protein 1-like OS=Homo sapiens GN=UHRF1BP1L PE=1 SV=2 PF09208 Restriction endonuclease MspI GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG4109 Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30 Cluster-8309.34068 BP_3 68.38 0.41 8333 189236457 XP_973878.2 2851 0.0e+00 PREDICTED: UHRF1-binding protein 1-like isoform X2 [Tribolium castaneum]>gi|270005939|gb|EFA02387.1| hypothetical protein TcasGA2_TC008067 [Tribolium castaneum] 507533084 XM_004650550.1 41 6.13808e-09 PREDICTED: Jaculus jaculus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA -- -- -- -- Q6NRZ1 751 1.8e-77 UHRF1-binding protein 1-like OS=Xenopus laevis GN=uhrf1bp1l PE=2 SV=1 PF09208 Restriction endonuclease MspI GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0009036//GO:0003677 Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex KOG4109 Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30 Cluster-8309.34069 BP_3 261.88 21.38 882 478255334 ENN75560.1 281 1.5e-22 hypothetical protein YQE_07903, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00917 MATH domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34073 BP_3 187.58 0.90 10381 270003689 EFA00137.1 2063 4.1e-228 hypothetical protein TcasGA2_TC002957 [Tribolium castaneum] 642916224 XM_008192715.1 270 3.83225e-136 PREDICTED: Tribolium castaneum uncharacterized LOC662985 (LOC662985), mRNA -- -- -- -- Q9V5L3 503 1.3e-48 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00439//PF00067//PF00631//PF02459 Bromodomain//Cytochrome P450//GGL domain//Adenoviral DNA terminal protein GO:0007165//GO:0006260//GO:0007186//GO:0055114 signal transduction//DNA replication//G-protein coupled receptor signaling pathway//oxidation-reduction process GO:0003677//GO:0016705//GO:0005515//GO:0004871//GO:0005506//GO:0020037 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//protein binding//signal transducer activity//iron ion binding//heme binding GO:0005834 heterotrimeric G-protein complex KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.34074 BP_3 4.10 0.34 882 662212463 XP_008479968.1 169 1.5e-09 PREDICTED: zinc finger protein 37-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.34075 BP_3 58.68 7.26 681 332373676 AEE61979.1 285 4.0e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34078 BP_3 519.45 6.90 3922 642918534 XP_008191512.1 3754 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 401 0 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q6ZP82 504 3.8e-49 Coiled-coil domain-containing protein 141 OS=Homo sapiens GN=CCDC141 PE=1 SV=2 PF01544//PF00435 CorA-like Mg2+ transporter protein//Spectrin repeat GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873//GO:0005515 metal ion transmembrane transporter activity//protein binding GO:0016020 membrane -- -- Cluster-8309.34081 BP_3 325.16 12.63 1533 546681897 ERL91906.1 906 8.7e-95 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 487 1.4e-47 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34082 BP_3 3.00 0.34 719 156320549 XP_001618200.1 218 2.5e-15 hypothetical protein NEMVEDRAFT_v1g155353 [Nematostella vectensis]>gi|156330400|ref|XP_001619109.1| hypothetical protein NEMVEDRAFT_v1g152336 [Nematostella vectensis]>gi|156197983|gb|EDO26100.1| predicted protein, partial [Nematostella vectensis]>gi|156201630|gb|EDO27009.1| predicted protein, partial [Nematostella vectensis] 496297311 KC573784.1 418 0 Carcinus maenas 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM6 180 2.6e-12 Protein TAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAR1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34083 BP_3 307.15 4.46 3610 91079594 XP_967887.1 1746 8.1e-192 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X1 [Tribolium castaneum]>gi|270003396|gb|EEZ99843.1| hypothetical protein TcasGA2_TC002624 [Tribolium castaneum] 194884182 XM_001976139.1 162 1.44187e-76 Drosophila erecta GG22721 (Dere\GG22721), mRNA K11975 RNF144 E3 ubiquitin-protein ligase RNF144 http://www.genome.jp/dbget-bin/www_bget?ko:K11975 Q925F3 770 5.0e-80 E3 ubiquitin-protein ligase RNF144A OS=Mus musculus GN=Rnf144a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.34084 BP_3 467.87 3.05 7696 642919872 XP_008192104.1 4568 0.0e+00 PREDICTED: UHRF1-binding protein 1-like isoform X1 [Tribolium castaneum] 507533084 XM_004650550.1 41 5.66677e-09 PREDICTED: Jaculus jaculus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA -- -- -- -- A0JNW5 972 4.0e-103 UHRF1-binding protein 1-like OS=Homo sapiens GN=UHRF1BP1L PE=1 SV=2 PF09208 Restriction endonuclease MspI GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG4109 Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30 Cluster-8309.34085 BP_3 2987.66 106.41 1645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34086 BP_3 326.88 4.63 3692 91084469 XP_970666.1 1690 2.6e-185 PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925528|ref|XP_008194588.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925531|ref|XP_008194589.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum] 817200928 XM_012420774.1 171 1.46455e-81 PREDICTED: Orussus abietinus transcription factor Sp1-like (LOC105697447), transcript variant X5, mRNA -- -- -- -- P18722 282 2.0e-23 Gastrula zinc finger protein XlCGF46.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF05191//PF00096//PF13465 Adenylate kinase, active site lid//Zinc finger, C2H2 type//Zinc-finger double domain GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.34088 BP_3 18.01 1.03 1138 817063822 XP_012253629.1 858 2.4e-89 PREDICTED: etoposide-induced protein 2.4 homolog [Athalia rosae] -- -- -- -- -- K10134 EI24 etoposide-induced 2.4 mRNA http://www.genome.jp/dbget-bin/www_bget?ko:K10134 Q08DE5 636 5.4e-65 Etoposide-induced protein 2.4 homolog OS=Bos taurus GN=EI24 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3966 p53-mediated apoptosis protein EI24/PIG8 Cluster-8309.34089 BP_3 329.45 9.48 1966 91083483 XP_971803.1 1750 1.5e-192 PREDICTED: tubulin polyglutamylase TTLL4 [Tribolium castaneum]>gi|270010834|gb|EFA07282.1| hypothetical protein TcasGA2_TC014517 [Tribolium castaneum] -- -- -- -- -- K16610 TTLL15 tubulin monoglycylase TTLL15 http://www.genome.jp/dbget-bin/www_bget?ko:K16610 A4Q9E8 267 5.7e-22 Tubulin polyglutamylase TTLL6 OS=Mus musculus GN=Ttll6 PE=2 SV=1 PF03133//PF07478 Tubulin-tyrosine ligase family//D-ala D-ala ligase C-terminus GO:0006464//GO:0046436//GO:0009252 cellular protein modification process//D-alanine metabolic process//peptidoglycan biosynthetic process GO:0008716 D-alanine-D-alanine ligase activity -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.34090 BP_3 42.03 15.81 419 642922682 XP_008193278.1 379 3.1e-34 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X10 [Tribolium castaneum] -- -- -- -- -- K04550 LRP1, CD91 low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor) http://www.genome.jp/dbget-bin/www_bget?ko:K04550 Q9JI18 316 2.5e-28 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34092 BP_3 5.20 0.37 964 662207644 XP_008477334.1 170 1.2e-09 PREDICTED: zinc finger protein 721-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 142 8.8e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF00643//PF04988//PF13465//PF02892//PF13912//PF01844//PF01428//PF00935//PF16622 Zinc finger, C2H2 type//B-box zinc finger//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//HNH endonuclease//AN1-like Zinc finger//Ribosomal protein L44//zinc-finger C2H2-type GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003676//GO:0003735//GO:0008270//GO:0046872//GO:0003677//GO:0004519 nucleic acid binding//structural constituent of ribosome//zinc ion binding//metal ion binding//DNA binding//endonuclease activity GO:0005622//GO:0005840//GO:0005634 intracellular//ribosome//nucleus -- -- Cluster-8309.34093 BP_3 47.20 6.33 651 478251391 ENN71857.1 257 6.7e-20 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 O74803 149 9.2e-09 UV excision repair protein rhp23 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rhp23 PE=1 SV=1 PF00995//PF09280 Sec1 family//XPC-binding domain GO:0006289//GO:0006904//GO:0016192//GO:0043161//GO:0006281 nucleotide-excision repair//vesicle docking involved in exocytosis//vesicle-mediated transport//proteasome-mediated ubiquitin-dependent protein catabolic process//DNA repair GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.34094 BP_3 517.53 4.93 5350 642920893 XP_973626.3 1474 4.2e-160 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09668 LARGE glycosyltransferase-like protein LARGE http://www.genome.jp/dbget-bin/www_bget?ko:K09668 Q66PG3 757 2.4e-78 Glycosyltransferase-like protein LARGE1 OS=Gallus gallus GN=LARGE PE=2 SV=1 PF00711//PF01545//PF01501//PF02844 Beta defensin//Cation efflux family//Glycosyl transferase family 8//Phosphoribosylglycinamide synthetase, N domain GO:0006812//GO:0055085//GO:0006144//GO:0006952//GO:0009113 cation transport//transmembrane transport//purine nucleobase metabolic process//defense response//purine nucleobase biosynthetic process GO:0008324//GO:0004637//GO:0016757 cation transmembrane transporter activity//phosphoribosylamine-glycine ligase activity//transferase activity, transferring glycosyl groups GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.34095 BP_3 123.15 13.54 730 91076494 XP_972946.1 560 5.5e-55 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 341 5.6e-31 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 PF01243 Pyridoxamine 5'-phosphate oxidase GO:0055114//GO:0008615 oxidation-reduction process//pyridoxine biosynthetic process GO:0004733//GO:0016491//GO:0010181 pyridoxamine-phosphate oxidase activity//oxidoreductase activity//FMN binding -- -- KOG3374 Cellular repressor of transcription Cluster-8309.34096 BP_3 107.00 9.78 819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34097 BP_3 724.89 7.60 4892 189238112 XP_001814047.1 481 5.3e-45 PREDICTED: bleomycin hydrolase [Tribolium castaneum]>gi|270008738|gb|EFA05186.1| hypothetical protein TcasGA2_TC015316 [Tribolium castaneum] 767931498 XM_005262871.3 83 1.61401e-32 PREDICTED: Homo sapiens KIAA0922 (KIAA0922), transcript variant X5, mRNA K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 Q8R016 366 4.7e-33 Bleomycin hydrolase OS=Mus musculus GN=Blmh PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG4128 Bleomycin hydrolases and aminopeptidases of cysteine protease family Cluster-8309.34098 BP_3 1686.40 21.88 4007 642911078 XP_008200566.1 2834 0.0e+00 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 913 1.5e-96 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF01585//PF00641//PF00076 G-patch domain//Zn-finger in Ran binding protein and others//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166//GO:0008270 nucleic acid binding//nucleotide binding//zinc ion binding GO:0005622 intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.34099 BP_3 268.48 2.79 4929 642919308 XP_008191819.1 4470 0.0e+00 PREDICTED: signal-induced proliferation-associated 1-like protein 2 isoform X2 [Tribolium castaneum] 642919307 XM_008193597.1 101 1.60346e-42 PREDICTED: Tribolium castaneum signal-induced proliferation-associated 1-like protein 2 (LOC660473), transcript variant X2, mRNA K17702 SIPA1L2, SPAL2 signal-induced proliferation-associated 1 like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17702 Q80TE4 1803 1.1e-199 Signal-induced proliferation-associated 1-like protein 2 OS=Mus musculus GN=Sipa1l2 PE=1 SV=3 PF06221//PF02145//PF00595 Putative zinc finger motif, C2HC5-type//Rap/ran-GAP//PDZ domain (Also known as DHR or GLGF) GO:0006355//GO:0051056 regulation of transcription, DNA-templated//regulation of small GTPase mediated signal transduction GO:0008270//GO:0005096//GO:0005515 zinc ion binding//GTPase activator activity//protein binding GO:0005634 nucleus KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.34100 BP_3 23.00 6.61 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34101 BP_3 1098.39 27.08 2247 478263357 ENN81733.1 230 3.1e-16 hypothetical protein YQE_01872, partial [Dendroctonus ponderosae]>gi|546681305|gb|ERL91419.1| hypothetical protein D910_08751 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:1903818//GO:0030431//GO:0032222 positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.34102 BP_3 171.27 1.79 4893 642938455 XP_008199810.1 4126 0.0e+00 PREDICTED: Niemann-Pick C1 protein isoform X1 [Tribolium castaneum] 657584210 XM_008298026.1 55 5.93077e-17 PREDICTED: Stegastes partitus Niemann-Pick disease, type C1 (npc1), transcript variant X2, mRNA K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 P56941 2256 3.3e-252 Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1 PF03176//PF02460//PF07677 MMPL family//Patched family//A-macroglobulin receptor GO:0007165 signal transduction GO:0008158 hedgehog receptor activity GO:0016020//GO:0005576 membrane//extracellular region KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.34104 BP_3 20.02 0.35 3065 91090594 XP_972814.1 2724 2.7e-305 PREDICTED: ATP-binding cassette sub-family F member 3 [Tribolium castaneum]>gi|270013337|gb|EFA09785.1| hypothetical protein TcasGA2_TC011927 [Tribolium castaneum] 755851249 XM_005175430.2 126 1.25707e-56 PREDICTED: Musca domestica ATP-binding cassette sub-family F member 3 (LOC101901338), mRNA K06158 ABCF3 ATP-binding cassette, subfamily F, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06158 Q8K268 2065 2.9e-230 ATP-binding cassette sub-family F member 3 OS=Mus musculus GN=Abcf3 PE=1 SV=1 PF02367//PF03205//PF03193//PF03266//PF00005//PF10662//PF00910//PF01926//PF13304//PF08477//PF01920//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//Molybdopterin guanine dinucleotide synthesis protein B//Protein of unknown function, DUF258//NTPase//ABC transporter//Ethanolamine utilisation - propanediol utilisation//RNA helicase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase//Prefoldin subunit//ATPase family associated with various cellular activities (AAA) GO:0007264//GO:0002949//GO:0006777//GO:0006200//GO:0006576//GO:0006457 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//Mo-molybdopterin cofactor biosynthetic process//obsolete ATP catabolic process//cellular biogenic amine metabolic process//protein folding GO:0003724//GO:0051082//GO:0005525//GO:0016887//GO:0003924//GO:0003723//GO:0005524//GO:0098519 RNA helicase activity//unfolded protein binding//GTP binding//ATPase activity//GTPase activity//RNA binding//ATP binding//nucleotide phosphatase activity, acting on free nucleotides GO:0016272 prefoldin complex KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b Cluster-8309.34106 BP_3 162.52 0.89 9053 642930846 XP_008196111.1 677 1.8e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34107 BP_3 196.93 3.59 2936 642929021 XP_008195658.1 2251 1.8e-250 PREDICTED: RNA-binding protein Nova-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14944 NOVA RNA-binding protein Nova http://www.genome.jp/dbget-bin/www_bget?ko:K14944 Q9UNW9 825 1.7e-86 RNA-binding protein Nova-2 OS=Homo sapiens GN=NOVA2 PE=1 SV=1 PF13184//PF13014//PF00013//PF07650 NusA-like KH domain//KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2191 RNA-binding protein NOVA1/PASILLA and related KH domain proteins Cluster-8309.34108 BP_3 3253.17 120.04 1598 91089503 XP_970142.1 1262 4.8e-136 PREDICTED: chloride intracellular channel exc-4 [Tribolium castaneum]>gi|270011391|gb|EFA07839.1| hypothetical protein TcasGA2_TC005408 [Tribolium castaneum] 642933335 XM_965049.3 275 9.62747e-140 PREDICTED: Tribolium castaneum chloride intracellular channel exc-4 (LOC658685), mRNA -- -- -- -- Q8WQA4 439 5.3e-42 Chloride intracellular channel exc-4 OS=Caenorhabditis elegans GN=exc-4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1422 Intracellular Cl- channel CLIC, contains GST domain Cluster-8309.34110 BP_3 627.57 6.30 5090 91084129 XP_969781.1 3082 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 76 1.3078e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1310 1.7e-142 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF06552//PF00005//PF03193//PF02456//PF00664//PF13304//PF01926 Plant specific mitochondrial import receptor subunit TOM20//ABC transporter//Protein of unknown function, DUF258//Adenovirus IVa2 protein//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0055085//GO:0019083//GO:0006810//GO:0006200//GO:0045040 transmembrane transport//viral transcription//transport//obsolete ATP catabolic process//protein import into mitochondrial outer membrane GO:0005524//GO:0003924//GO:0016887//GO:0005525//GO:0042626 ATP binding//GTPase activity//ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0005742 integral component of membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.34112 BP_3 267.27 9.01 1722 488510886 XP_004447524.1 544 9.3e-53 PREDICTED: zinc finger protein 227 [Dasypus novemcinctus]>gi|488510888|ref|XP_004447525.1| PREDICTED: zinc finger protein 227 [Dasypus novemcinctus]>gi|821099212|ref|XP_012380376.1| PREDICTED: zinc finger protein 227 [Dasypus novemcinctus] 880968524 XM_013125934.1 35 2.70354e-06 PREDICTED: Mesocricetus auratus zinc finger protein 431-like (LOC101825632), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86WZ6 527 3.6e-52 Zinc finger protein 227 OS=Homo sapiens GN=ZNF227 PE=1 SV=1 PF13465//PF00096//PF07776//PF16622//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.34113 BP_3 83.81 4.36 1219 91082225 XP_976021.1 1003 3.9e-106 PREDICTED: four and a half LIM domains protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 O43900 375 1.1e-34 Prickle-like protein 3 OS=Homo sapiens GN=PRICKLE3 PE=1 SV=2 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.34114 BP_3 123.29 2.90 2339 91080595 XP_973935.1 1079 1.2e-114 PREDICTED: caseinolytic peptidase B protein homolog [Tribolium castaneum]>gi|270005512|gb|EFA01960.1| hypothetical protein TcasGA2_TC007578 [Tribolium castaneum] 612023545 XM_007491044.1 80 3.56401e-31 PREDICTED: Monodelphis domestica ClpB caseinolytic peptidase B homolog (E. coli) (CLPB), transcript variant X4, mRNA K03695 clpB ATP-dependent Clp protease ATP-binding subunit ClpB http://www.genome.jp/dbget-bin/www_bget?ko:K03695 Q9H078 847 3.8e-89 Caseinolytic peptidase B protein homolog OS=Homo sapiens GN=CLPB PE=1 SV=1 PF06414//PF03193//PF00023//PF00910//PF00158//PF13606//PF05496//PF08477//PF07728//PF00448//PF07724//PF06309//PF00004 Zeta toxin//Protein of unknown function, DUF258//Ankyrin repeat//RNA helicase//Sigma-54 interaction domain//Ankyrin repeat//Holliday junction DNA helicase ruvB N-terminus//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//SRP54-type protein, GTPase domain//AAA domain (Cdc48 subfamily)//Torsin//ATPase family associated with various cellular activities (AAA) GO:0007264//GO:0006310//GO:0006355//GO:0006281//GO:0006614 small GTPase mediated signal transduction//DNA recombination//regulation of transcription, DNA-templated//DNA repair//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0009378//GO:0017111//GO:0005525//GO:0005515//GO:0003723//GO:0016887//GO:0016301//GO:0003924//GO:0008134//GO:0005524 RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//GTP binding//protein binding//RNA binding//ATPase activity//kinase activity//GTPase activity//transcription factor binding//ATP binding GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases Cluster-8309.34115 BP_3 330.58 7.60 2387 91081621 XP_966892.1 1489 3.4e-162 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 862 7.1e-91 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.34124 BP_3 7.53 0.57 929 264667319 ACY71245.1 426 2.4e-39 ribosomal protein L12 [Chrysomela tremula] -- -- -- -- -- K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P23358 380 2.1e-35 60S ribosomal protein L12 OS=Rattus norvegicus GN=Rpl12 PE=2 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-8309.34126 BP_3 1713.12 38.24 2451 642919618 XP_008191942.1 2169 4.9e-241 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] 642919617 XM_008193720.1 423 0 PREDICTED: Tribolium castaneum protein kinase C and casein kinase substrate in neurons protein 1 (LOC103312632), mRNA -- -- -- -- Q4V920 1060 8.0e-114 Protein kinase C and casein kinase substrate in neurons protein 1 OS=Danio rerio GN=pacsin1b PE=1 SV=1 PF03938//PF01623//PF00018//PF14604//PF08397//PF03947 Outer membrane protein (OmpH-like)//Carlavirus putative nucleic acid binding protein//SH3 domain//Variant SH3 domain//IRSp53/MIM homology domain//Ribosomal Proteins L2, C-terminal domain GO:0042254//GO:0006355//GO:0007009//GO:0006412 ribosome biogenesis//regulation of transcription, DNA-templated//plasma membrane organization//translation GO:0003735//GO:0051082//GO:0003676//GO:0005515 structural constituent of ribosome//unfolded protein binding//nucleic acid binding//protein binding GO:0005840 ribosome KOG2856 Adaptor protein PACSIN Cluster-8309.34127 BP_3 665.13 4.52 7388 642929723 XP_008195952.1 2535 5.4e-283 PREDICTED: spastin [Tribolium castaneum]>gi|270010589|gb|EFA07037.1| hypothetical protein TcasGA2_TC010011 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.44896e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q14738 2003 1.1e-222 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens GN=PPP2R5D PE=1 SV=1 PF00004//PF07724//PF01695//PF07728//PF05496//PF01603//PF06068 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//TIP49 C-terminus GO:0007165//GO:0006281//GO:0006310 signal transduction//DNA repair//DNA recombination GO:0008601//GO:0008568//GO:0005524//GO:0003678//GO:0016887//GO:0009378 protein phosphatase type 2A regulator activity//microtubule-severing ATPase activity//ATP binding//DNA helicase activity//ATPase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0000159 Holliday junction helicase complex//replication fork//protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.34128 BP_3 15.31 1.37 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34129 BP_3 113.43 9.29 880 642910991 XP_008193498.1 509 5.4e-49 PREDICTED: FUN14 domain-containing protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17986 FUNDC1 FUN14 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17986 Q6DFJ3 245 9.2e-20 FUN14 domain-containing protein 1B OS=Xenopus laevis GN=fundc1-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4099 Predicted membrane protein Cluster-8309.34130 BP_3 652.89 21.32 1768 642938587 XP_008199853.1 144 2.3e-06 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X2 [Tribolium castaneum] 642938586 XM_008201631.1 130 4.2994e-59 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF01235 Sodium:alanine symporter family GO:0015846//GO:0006814//GO:0032328//GO:0015804 polyamine transport//sodium ion transport//alanine transport//neutral amino acid transport GO:0015655 alanine:sodium symporter activity GO:0016020 membrane -- -- Cluster-8309.34131 BP_3 18.98 1.21 1050 91085777 XP_974360.1 549 1.5e-53 PREDICTED: 60S ribosomal protein L23 [Tribolium castaneum]>gi|270010126|gb|EFA06574.1| hypothetical protein TcasGA2_TC009485 [Tribolium castaneum] 110671519 DQ673438.1 126 4.21917e-57 Diaphorina citri putative ribosomal protein L17/23 mRNA, complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P48159 523 6.3e-52 60S ribosomal protein L23 OS=Drosophila melanogaster GN=RpL23 PE=1 SV=2 PF09254//PF17123//PF00238 Restriction endonuclease FokI, C terminal//RING-like zinc finger//Ribosomal protein L14p/L23e GO:0006308//GO:0042254//GO:0009307//GO:0006412 DNA catabolic process//ribosome biogenesis//DNA restriction-modification system//translation GO:0003735//GO:0008270//GO:0005515//GO:0009036//GO:0003677 structural constituent of ribosome//zinc ion binding//protein binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359//GO:0005840 Type II site-specific deoxyribonuclease complex//ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.34135 BP_3 656.54 7.23 4669 91090558 XP_971487.1 1781 9.2e-196 PREDICTED: translation initiation factor eIF-2B subunit gamma [Tribolium castaneum]>gi|270013887|gb|EFA10335.1| hypothetical protein TcasGA2_TC012553 [Tribolium castaneum] 751447204 XM_011179427.1 197 6.53492e-96 PREDICTED: Bactrocera cucurbitae elongation of very long chain fatty acids protein AAEL008004 (LOC105209165), transcript variant X2, mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1017 1.5e-108 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF07959//PF00483//PF01128//PF01151 L-fucokinase//Nucleotidyl transferase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//GNS1/SUR4 family GO:0009058//GO:0008299//GO:0006694 biosynthetic process//isoprenoid biosynthetic process//steroid biosynthetic process GO:0016772//GO:0050518//GO:0016779 transferase activity, transferring phosphorus-containing groups//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.34136 BP_3 58.88 0.64 4720 91091704 XP_972821.1 3072 0.0e+00 PREDICTED: phosphatidylinositol 4-kinase beta [Tribolium castaneum]>gi|270001265|gb|EEZ97712.1| four wheel drive [Tribolium castaneum] 830114741 XM_004689541.2 193 1.10556e-93 PREDICTED: Condylura cristata phosphatidylinositol 4-kinase, catalytic, beta (PI4KB), transcript variant X2, mRNA K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 B4UT09 1741 1.7e-192 Phosphatidylinositol 4-kinase beta OS=Otolemur garnettii GN=PI4KB PE=3 SV=1 PF08288//PF07415//PF00454 PIGA (GPI anchor biosynthesis)//Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphatidylinositol 3- and 4-kinase GO:0016310//GO:0006506//GO:0019042//GO:0046488 phosphorylation//GPI anchor biosynthetic process//viral latency//phosphatidylinositol metabolic process GO:0016301//GO:0016773 kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0033644 host cell membrane KOG0903 Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion Cluster-8309.34137 BP_3 3123.11 34.84 4612 91091704 XP_972821.1 3200 0.0e+00 PREDICTED: phosphatidylinositol 4-kinase beta [Tribolium castaneum]>gi|270001265|gb|EEZ97712.1| four wheel drive [Tribolium castaneum] 830114741 XM_004689541.2 199 4.98965e-97 PREDICTED: Condylura cristata phosphatidylinositol 4-kinase, catalytic, beta (PI4KB), transcript variant X2, mRNA K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 B4UT09 1840 5.4e-204 Phosphatidylinositol 4-kinase beta OS=Otolemur garnettii GN=PI4KB PE=3 SV=1 PF08288//PF07415//PF00454 PIGA (GPI anchor biosynthesis)//Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphatidylinositol 3- and 4-kinase GO:0016310//GO:0006506//GO:0019042//GO:0046488 phosphorylation//GPI anchor biosynthetic process//viral latency//phosphatidylinositol metabolic process GO:0016301//GO:0016773 kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0033644 host cell membrane KOG0903 Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion Cluster-8309.34138 BP_3 958.58 10.87 4542 642923932 XP_008193933.1 1449 2.8e-157 PREDICTED: choline-phosphate cytidylyltransferase A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K00968 PCYT1 choline-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00968 P49585 808 2.5e-84 Choline-phosphate cytidylyltransferase A OS=Homo sapiens GN=PCYT1A PE=1 SV=2 PF01733//PF12326//PF01467//PF00600 Nucleoside transporter//N-glycosylation protein//Cytidylyltransferase-like//Influenza non-structural protein (NS1) GO:0009058//GO:0034599//GO:0006810//GO:0015858 biosynthetic process//cellular response to oxidative stress//transport//nucleoside transport GO:0005337//GO:0003723//GO:0003824 nucleoside transmembrane transporter activity//RNA binding//catalytic activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-8309.34139 BP_3 13.42 0.65 1289 91094297 XP_971720.1 1036 6.2e-110 PREDICTED: estradiol 17-beta-dehydrogenase 12 [Tribolium castaneum]>gi|270014405|gb|EFA10853.1| hypothetical protein TcasGA2_TC001630 [Tribolium castaneum] -- -- -- -- -- K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10251 Q28IU1 666 2.0e-68 Very-long-chain 3-oxoacyl-CoA reductase OS=Xenopus tropicalis GN=hsd17b12 PE=2 SV=1 PF00106//PF02737//PF01370//PF03435 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain GO:0006568//GO:0006631//GO:0055114//GO:0006552//GO:0006554//GO:0008152//GO:0018874//GO:0006633//GO:0006550//GO:0006574 tryptophan metabolic process//fatty acid metabolic process//oxidation-reduction process//leucine catabolic process//lysine catabolic process//metabolic process//benzoate metabolic process//fatty acid biosynthetic process//isoleucine catabolic process//valine catabolic process GO:0000166//GO:0003857//GO:0050662//GO:0003824//GO:0016491 nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.34141 BP_3 199.83 2.11 4866 642924963 XP_008194117.1 2699 3.4e-302 PREDICTED: coiled-coil domain-containing protein AGAP005037 isoform X9 [Tribolium castaneum] 795104299 XM_012026023.1 48 4.59165e-13 PREDICTED: Vollenhovia emeryi coiled-coil domain-containing protein CG32809 (LOC105569508), mRNA -- -- -- -- Q7PQ25 850 3.6e-89 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF01025//PF02970//PF07989 GrpE//Tubulin binding cofactor A//Centrosomin N-terminal motif 1 GO:0007021//GO:0006457 tubulin complex assembly//protein folding GO:0042803//GO:0051087//GO:0051082//GO:0000774//GO:0015631 protein homodimerization activity//chaperone binding//unfolded protein binding//adenyl-nucleotide exchange factor activity//tubulin binding GO:0045298//GO:0005815 tubulin complex//microtubule organizing center -- -- Cluster-8309.34143 BP_3 3.00 1.27 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01101 HMG14 and HMG17 -- -- GO:0031492 nucleosomal DNA binding GO:0000785//GO:0005634 chromatin//nucleus -- -- Cluster-8309.34145 BP_3 383.57 7.59 2727 91091018 XP_975107.1 2378 3.2e-265 PREDICTED: F-box/LRR-repeat protein 2 isoform X1 [Tribolium castaneum]>gi|270013173|gb|EFA09621.1| hypothetical protein TcasGA2_TC011742 [Tribolium castaneum] 571506739 XM_397111.4 233 3.68979e-116 PREDICTED: Apis mellifera f-box/LRR-repeat protein 2-like (LOC413670), transcript variant X1, mRNA -- -- -- -- Q8BH16 206 9.4e-15 F-box/LRR-repeat protein 2 OS=Mus musculus GN=Fbxl2 PE=1 SV=1 PF12937//PF13639//PF15966//PF00646 F-box-like//Ring finger domain//F-box//F-box domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.34146 BP_3 48.15 0.55 4506 642923468 XP_008193757.1 594 3.9e-58 PREDICTED: glia maturation factor beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49858 447 1.8e-42 Protein cornichon OS=Drosophila melanogaster GN=cni PE=1 SV=1 PF03311//PF00241 Cornichon protein//Cofilin/tropomyosin-type actin-binding protein GO:0035556 intracellular signal transduction GO:0003779 actin binding GO:0005622//GO:0016020 intracellular//membrane KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.34147 BP_3 12.44 0.56 1357 861660122 KMR04875.1 183 5.3e-11 longitudinals lacking isoforms a b d l [Lasius niger] -- -- -- -- -- -- -- -- -- Q7KQZ4 149 1.9e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF01096//PF13912//PF17123 Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//C2H2-type zinc finger//RING-like zinc finger GO:0006351 transcription, DNA-templated GO:0005515//GO:0046872//GO:0008270//GO:0003676 protein binding//metal ion binding//zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.34148 BP_3 3.14 0.98 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34149 BP_3 3000.64 55.56 2895 761896177 AJP75146.1 2147 2.1e-238 alanine aminotransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 Q6NYL5 1513 2.8e-166 Alanine aminotransferase 2-like OS=Danio rerio GN=gpt2l PE=2 SV=2 PF01212//PF00155 Beta-eliminating lyase//Aminotransferase class I and II GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0258 Alanine aminotransferase Cluster-8309.34150 BP_3 46.53 0.34 6857 642935257 XP_008197935.1 1463 1.0e-158 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 424 1.3e-39 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.34151 BP_3 51.68 0.89 3102 91089337 XP_972494.1 1132 1.1e-120 PREDICTED: protein singed [Tribolium castaneum]>gi|270012518|gb|EFA08966.1| hypothetical protein TcasGA2_TC006673 [Tribolium castaneum] 642933078 XM_967401.2 245 8.97217e-123 PREDICTED: Tribolium castaneum protein singed (LOC661226), mRNA K17455 FSCN1_2 fascin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17455 Q24524 774 1.5e-80 Protein singed OS=Drosophila melanogaster GN=sn PE=3 SV=1 PF01786//PF00167//PF06268//PF01529 Alternative oxidase//Fibroblast growth factor//Fascin domain//DHHC palmitoyltransferase GO:0055114//GO:0006118//GO:0008283//GO:0007165//GO:0040007 oxidation-reduction process//obsolete electron transport//cell proliferation//signal transduction//growth GO:0030674//GO:0008270//GO:0051015//GO:0009916//GO:0008083 protein binding, bridging//zinc ion binding//actin filament binding//alternative oxidase activity//growth factor activity -- -- -- -- Cluster-8309.34154 BP_3 79.32 1.11 3733 332372548 AEE61416.1 588 1.6e-57 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IZJ3 200 6.4e-14 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 OS=Homo sapiens GN=CPAMD8 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34155 BP_3 697.29 13.88 2714 642934848 XP_008197836.1 1564 7.8e-171 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JR59 239 1.4e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34156 BP_3 20.78 1.60 918 642920332 XP_975626.2 404 8.5e-37 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17078//PF04048 SWI5-dependent HO expression protein 3//Sec8 exocyst complex component specific domain GO:0051028//GO:0006904//GO:0048309//GO:0015031 mRNA transport//vesicle docking involved in exocytosis//endoplasmic reticulum inheritance//protein transport -- -- GO:0000145 exocyst KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.34158 BP_3 633.80 46.27 952 91078932 XP_967475.1 352 9.4e-31 PREDICTED: glutathione S-transferase [Tribolium castaneum]>gi|642916286|ref|XP_008190960.1| PREDICTED: glutathione S-transferase [Tribolium castaneum]>gi|270004172|gb|EFA00620.1| hypothetical protein TcasGA2_TC003496 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 O18598 347 1.5e-31 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3416 BP_3 9.00 1.33 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34160 BP_3 631.36 18.61 1927 674304034 AIL23548.1 668 4.3e-67 glutathione S-transferase sigma [Tenebrio molitor] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 607 2.1e-61 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.34161 BP_3 30.64 0.70 2406 674304034 AIL23548.1 668 5.4e-67 glutathione S-transferase sigma [Tenebrio molitor] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 602 1.0e-60 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.34162 BP_3 37.15 0.78 2578 91078932 XP_967475.1 323 5.9e-27 PREDICTED: glutathione S-transferase [Tribolium castaneum]>gi|642916286|ref|XP_008190960.1| PREDICTED: glutathione S-transferase [Tribolium castaneum]>gi|270004172|gb|EFA00620.1| hypothetical protein TcasGA2_TC003496 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O18598 316 1.6e-27 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.34164 BP_3 40.07 1.20 1906 642917782 XP_008191284.1 1769 9.2e-195 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [Tribolium castaneum] 170065886 XM_001868022.1 354 0 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 1661 1.3e-183 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.34166 BP_3 1615.94 119.23 945 91090704 XP_974824.1 366 2.2e-32 PREDICTED: putative acyl-CoA-binding protein [Tribolium castaneum]>gi|270013948|gb|EFA10396.1| hypothetical protein TcasGA2_TC012627 [Tribolium castaneum] -- -- -- -- -- K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) http://www.genome.jp/dbget-bin/www_bget?ko:K08762 P31824 305 1.1e-26 Acyl-CoA-binding protein homolog OS=Manduca sexta PE=3 SV=1 PF00887//PF01613 Acyl CoA binding protein//Flavin reductase like domain -- -- GO:0000062//GO:0010181 fatty-acyl-CoA binding//FMN binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-8309.34168 BP_3 914.72 14.50 3332 570341948 AHE77372.1 614 1.4e-60 small heat shock protein [Lissorhoptrus oryzophilus] 570341961 KC620429.1 60 6.68722e-20 Lissorhoptrus oryzophilus small heat shock protein (HSP27e) mRNA, partial cds K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 351 1.8e-31 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF09066//PF01873//PF00525 Beta2-adaptin appendage, C-terminal sub-domain//Domain found in IF2B/IF5//Alpha crystallin A chain, N terminal GO:0007423//GO:0016192//GO:0006446//GO:0006886//GO:0006413 sensory organ development//vesicle-mediated transport//regulation of translational initiation//intracellular protein transport//translational initiation GO:0003743//GO:0005212 translation initiation factor activity//structural constituent of eye lens GO:0030131//GO:0005840 clathrin adaptor complex//ribosome -- -- Cluster-8309.34169 BP_3 2940.58 468.81 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3417 BP_3 93.03 3.25 1671 607353521 EZA48267.1 198 1.2e-12 hypothetical protein X777_14099 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34170 BP_3 1224.00 26.68 2503 270013282 EFA09730.1 639 1.3e-63 hypothetical protein TcasGA2_TC011863 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0BM39 160 1.9e-09 Tetraspanin-9 OS=Xenopus tropicalis GN=tspan9 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.34172 BP_3 156.49 3.31 2572 546675568 ERL86737.1 1448 2.1e-157 hypothetical protein D910_04143 [Dendroctonus ponderosae] -- -- -- -- -- K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 605 4.8e-61 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF16622//PF02892//PF13912//PF13465//PF00096 BTB/POZ domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872//GO:0005515 DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.34173 BP_3 69.91 0.75 4808 642923522 XP_008193544.1 3348 0.0e+00 PREDICTED: anoctamin-4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q32M45 1447 2.1e-158 Anoctamin-4 OS=Homo sapiens GN=ANO4 PE=2 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- KOG2514 Uncharacterized conserved protein Cluster-8309.34174 BP_3 541.75 8.67 3302 478256841 ENN77016.1 1079 1.6e-114 hypothetical protein YQE_06510, partial [Dendroctonus ponderosae]>gi|546673799|gb|ERL85343.1| hypothetical protein D910_02763 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V785 768 7.8e-80 SH3 domain-binding protein 5 homolog OS=Drosophila melanogaster GN=pcs PE=1 SV=4 PF07851//PF01484 TMPIT-like protein//Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.34178 BP_3 546.20 14.16 2151 91088951 XP_973830.1 922 1.7e-96 PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|642932526|ref|XP_008197151.1| PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011559|gb|EFA08007.1| hypothetical protein TcasGA2_TC005596 [Tribolium castaneum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 P16219 704 1.3e-72 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADS PE=1 SV=1 PF02770//PF00441//PF02771 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0006118//GO:0008152 oxidation-reduction process//obsolete electron transport//metabolic process GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.34179 BP_3 72.74 1.04 3677 91088951 XP_973830.1 871 2.4e-90 PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|642932526|ref|XP_008197151.1| PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011559|gb|EFA08007.1| hypothetical protein TcasGA2_TC005596 [Tribolium castaneum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 P16219 662 1.7e-67 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADS PE=1 SV=1 PF00441//PF02771//PF02770 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.34180 BP_3 16.18 0.51 1816 642937100 XP_008198691.1 689 1.5e-69 PREDICTED: uncharacterized protein LOC659764 [Tribolium castaneum] -- -- -- -- -- K16315 GSG2 serine/threonine-protein kinase haspin http://www.genome.jp/dbget-bin/www_bget?ko:K16315 P83103 405 5.3e-38 Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster GN=Haspin PE=2 SV=1 PF00069//PF03121 Protein kinase domain//Herpesviridae UL52/UL70 DNA primase GO:0006468//GO:0006351//GO:0006260//GO:0006269 protein phosphorylation//transcription, DNA-templated//DNA replication//DNA replication, synthesis of RNA primer GO:0005524//GO:0003896//GO:0004672 ATP binding//DNA primase activity//protein kinase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2464 Serine/threonine kinase (haspin family) Cluster-8309.34181 BP_3 71.34 1.00 3743 270013391 EFA09839.1 785 2.3e-80 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 194893319 XM_001977817.1 90 1.58261e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- P08897 240 1.5e-18 Collagenase OS=Hypoderma lineatum PE=1 SV=3 PF00008//PF06373//PF00089 EGF-like domain//Cocaine and amphetamine regulated transcript protein (CART)//Trypsin GO:0009267//GO:0007186//GO:0000186//GO:0006508//GO:0001678//GO:0008343//GO:0032099 cellular response to starvation//G-protein coupled receptor signaling pathway//activation of MAPKK activity//proteolysis//cellular glucose homeostasis//adult feeding behavior//negative regulation of appetite GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding GO:0005615 extracellular space -- -- Cluster-8309.34186 BP_3 412.00 8.70 2573 642910945 XP_008193476.1 725 1.4e-73 PREDICTED: regulator of G-protein signaling 17 [Tribolium castaneum] 642910944 XM_008195254.1 78 5.07857e-30 PREDICTED: Tribolium castaneum regulator of G-protein signaling 17 (LOC661591), mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9PWA1 541 1.3e-53 Regulator of G-protein signaling 20 OS=Gallus gallus GN=RGS20 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3589 G protein signaling regulators Cluster-8309.34190 BP_3 710.10 6.16 5850 270002665 EEZ99112.1 1303 3.1e-140 hypothetical protein TcasGA2_TC005005 [Tribolium castaneum] 817188844 XM_012433587.1 77 4.18298e-29 PREDICTED: Orussus abietinus RING finger protein 44 (LOC105704395), partial mRNA K19041 RNF38_44 E3 ubiquitin-protein ligase RNF38/44 http://www.genome.jp/dbget-bin/www_bget?ko:K19041 Q08CG8 412 2.6e-38 RING finger protein 44 OS=Danio rerio GN=rnf44 PE=2 SV=1 PF17123//PF12906//PF12678//PF14634//PF00097//PF00287//PF12861//PF13639 RING-like zinc finger//RING-variant domain//RING-H2 zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Sodium / potassium ATPase beta chain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0006814//GO:0006813//GO:0016567 sodium ion transport//potassium ion transport//protein ubiquitination GO:0008270//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005890//GO:0005680 sodium:potassium-exchanging ATPase complex//anaphase-promoting complex -- -- Cluster-8309.34191 BP_3 616.90 17.22 2018 91094775 XP_968026.1 302 1.3e-24 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- K10146 CCNG2 cyclin G2 http://www.genome.jp/dbget-bin/www_bget?ko:K10146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34195 BP_3 1342.45 33.14 2244 478263405 ENN81776.1 907 9.8e-95 hypothetical protein YQE_01836, partial [Dendroctonus ponderosae]>gi|546671271|gb|ERL83654.1| hypothetical protein D910_00815 [Dendroctonus ponderosae] 642926418 XM_965939.2 289 2.24487e-147 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2 G1 (LOC659653), mRNA K10575 UBE2G1, UBC7 ubiquitin-conjugating enzyme E2 G1 http://www.genome.jp/dbget-bin/www_bget?ko:K10575 P62253 784 7.4e-82 Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens GN=UBE2G1 PE=1 SV=3 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0425 Ubiquitin-protein ligase Cluster-8309.34196 BP_3 430.58 3.20 6780 270007202 EFA03650.1 2336 5.9e-260 hypothetical protein TcasGA2_TC013744 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.9449e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 Q5SF07 1014 4.8e-108 Insulin-like growth factor 2 mRNA-binding protein 2 OS=Mus musculus GN=Igf2bp2 PE=1 SV=1 PF00076//PF07650//PF04061//PF00013//PF13014//PF13184 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//KH domain//ORMDL family//KH domain//KH domain//NusA-like KH domain -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.34197 BP_3 26.11 0.88 1727 332376633 AEE63456.1 1888 1.3e-208 unknown [Dendroctonus ponderosae] 195434135 XM_002065023.1 48 1.60901e-13 Drosophila willistoni GK15257 (Dwil\GK15257), mRNA -- -- -- -- Q96P53 1203 1.5e-130 WD repeat and FYVE domain-containing protein 2 OS=Homo sapiens GN=WDFY2 PE=2 SV=2 PF07365//PF01363//PF00400 Alpha conotoxin precursor//FYVE zinc finger//WD domain, G-beta repeat GO:0009405//GO:0007165//GO:0007268 pathogenesis//signal transduction//synaptic transmission GO:0005515//GO:0030550//GO:0046872 protein binding//acetylcholine receptor inhibitor activity//metal ion binding GO:0005576 extracellular region KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.34199 BP_3 1987.00 50.19 2200 189234794 XP_001807213.1 1185 5.6e-127 PREDICTED: protein SMG5 [Tribolium castaneum] 642914408 XM_001807161.2 172 2.4121e-82 PREDICTED: Tribolium castaneum protein SMG5 (LOC100142092), mRNA K11125 SMG5, EST1B protein SMG5 http://www.genome.jp/dbget-bin/www_bget?ko:K11125 Q9UPR3 453 1.7e-43 Protein SMG5 OS=Homo sapiens GN=SMG5 PE=1 SV=3 PF13414//PF00515 TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG3300 NADH:ubiquinone oxidoreductase, B16.6 subunit/cell death-regulatory protein Cluster-8309.3420 BP_3 4.00 0.33 883 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34200 BP_3 1222.67 5.16 11719 270011779 EFA08227.1 2250 9.5e-250 hypothetical protein TcasGA2_TC005854 [Tribolium castaneum] 642931619 XM_966443.2 176 7.77311e-84 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 Q92523 1265 6.5e-137 Carnitine O-palmitoyltransferase 1, muscle isoform OS=Homo sapiens GN=CPT1B PE=1 SV=2 PF00755//PF01532 Choline/Carnitine o-acyltransferase//Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571//GO:0016746 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2430 Glycosyl hydrolase, family 47 Cluster-8309.34201 BP_3 20.59 0.35 3163 91091818 XP_966528.1 1397 2.1e-151 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 970 2.8e-103 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF03594//PF02321//PF10613//PF00060 Benzoate membrane transport protein//Outer membrane efflux protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006811//GO:0007268//GO:0006810//GO:0007165//GO:0042919 ion transport//synaptic transmission//transport//signal transduction//benzoate transport GO:0005216//GO:0042925//GO:0005215//GO:0005234//GO:0004970 ion channel activity//benzoate transporter activity//transporter activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.34205 BP_3 951.82 91.89 791 642920914 XP_008192613.1 845 5.3e-88 PREDICTED: outer dense fiber protein 3-B isoform X2 [Tribolium castaneum]>gi|270006132|gb|EFA02580.1| hypothetical protein TcasGA2_TC008298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 266 3.0e-22 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 PF05953 Allatostatin GO:0007218 neuropeptide signaling pathway GO:0005184 neuropeptide hormone activity -- -- -- -- Cluster-8309.34206 BP_3 10703.00 982.12 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02935//PF00684 Cytochrome c oxidase subunit VIIc//DnaJ central domain GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0031072//GO:0051082 cytochrome-c oxidase activity//heat shock protein binding//unfolded protein binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.34207 BP_3 10.36 0.66 1049 91076434 XP_971068.1 378 1.0e-33 PREDICTED: U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [Tribolium castaneum]>gi|270002571|gb|EEZ99018.1| hypothetical protein TcasGA2_TC004886 [Tribolium castaneum] -- -- -- -- -- K12846 SNRNP27 U4/U6.U5 tri-snRNP-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12846 Q8WVK2 239 5.4e-19 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens GN=SNRNP27 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3263 Nucleic acid binding protein Cluster-8309.34208 BP_3 562.64 40.52 961 91076434 XP_971068.1 378 9.2e-34 PREDICTED: U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [Tribolium castaneum]>gi|270002571|gb|EEZ99018.1| hypothetical protein TcasGA2_TC004886 [Tribolium castaneum] -- -- -- -- -- K12846 SNRNP27 U4/U6.U5 tri-snRNP-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12846 Q8WVK2 239 4.9e-19 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens GN=SNRNP27 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3263 Nucleic acid binding protein Cluster-8309.34210 BP_3 37.24 1.73 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34212 BP_3 369.88 26.84 956 332376981 AEE63630.1 250 6.4e-19 unknown [Dendroctonus ponderosae]>gi|478249889|gb|ENN70396.1| hypothetical protein YQE_12902, partial [Dendroctonus ponderosae]>gi|546683395|gb|ERL93214.1| hypothetical protein D910_10510 [Dendroctonus ponderosae] -- -- -- -- -- K17784 MINOS1, MOS1 mitochondrial inner membrane organizing system protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17784 Q5TGZ0 152 6.0e-09 MICOS complex subunit MIC10 OS=Homo sapiens GN=MINOS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4604 Uncharacterized conserved protein Cluster-8309.34215 BP_3 927.00 14.33 3409 668453610 KFB42261.1 1592 5.5e-174 AGAP009649-PA-like protein [Anopheles sinensis] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9NRA2 826 1.5e-86 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690//PF06963//PF00083 Major Facilitator Superfamily//Ferroportin1 (FPN1)//Sugar (and other) transporter GO:0006826//GO:0034755//GO:0055085 iron ion transport//iron ion transmembrane transport//transmembrane transport GO:0022857//GO:0005381 transmembrane transporter activity//iron ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.34216 BP_3 69.80 2.34 1730 642928374 XP_008192717.1 944 3.9e-99 PREDICTED: C-1-tetrahydrofolate synthase, cytoplasmic isoform X1 [Tribolium castaneum] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 O96553 852 7.4e-90 C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster GN=pug PE=1 SV=4 PF02882//PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.34217 BP_3 1549.83 9.58 8092 642925750 XP_008201602.1 1207 5.8e-129 PREDICTED: micronuclear linker histone polyprotein-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00999 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00999 O14735 640 1.3e-64 CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Homo sapiens GN=CDIPT PE=1 SV=1 PF03967//PF01066 Photosynthetic reaction centre, H-chain N-terminal region//CDP-alcohol phosphatidyltransferase GO:0019684//GO:0008654//GO:0006118 photosynthesis, light reaction//phospholipid biosynthetic process//obsolete electron transport GO:0045156//GO:0016780 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//phosphotransferase activity, for other substituted phosphate groups GO:0030077//GO:0016020 plasma membrane light-harvesting complex//membrane KOG3240 Phosphatidylinositol synthase Cluster-8309.34218 BP_3 19.78 0.40 2668 332374254 AEE62268.1 1201 9.4e-129 unknown [Dendroctonus ponderosae]>gi|546686166|gb|ERL95552.1| hypothetical protein D910_12813 [Dendroctonus ponderosae] -- -- -- -- -- K09507 DNAJB1 DnaJ homolog subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09507 Q24133 767 8.2e-80 DnaJ protein homolog 1 OS=Drosophila melanogaster GN=DnaJ-1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.3422 BP_3 3.00 4.12 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34221 BP_3 34.58 0.96 2027 91082507 XP_973065.1 1516 2.1e-165 PREDICTED: protein kinase DC2 [Tribolium castaneum]>gi|270007546|gb|EFA03994.1| hypothetical protein TcasGA2_TC014143 [Tribolium castaneum] 645007450 XM_008218052.1 132 3.82036e-60 PREDICTED: Nasonia vitripennis protein kinase DC2 (LOC100119822), transcript variant X4, mRNA K19584 PRKX protein kinase X http://www.genome.jp/dbget-bin/www_bget?ko:K19584 P16912 1277 4.5e-139 Protein kinase DC2 OS=Drosophila melanogaster GN=Pka-C3 PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA) Cluster-8309.34224 BP_3 10.00 0.74 946 189237508 XP_972374.2 584 1.2e-57 PREDICTED: protein D2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 471 6.1e-46 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.34225 BP_3 303.00 4.16 3805 642937943 XP_969804.2 1363 2.2e-147 PREDICTED: YTH domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96MU7 584 1.9e-58 YTH domain-containing protein 1 OS=Homo sapiens GN=YTHDC1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1902 Putative signal transduction protein involved in RNA splicing Cluster-8309.34226 BP_3 8.00 1.10 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34227 BP_3 4333.14 446.96 759 332375004 AEE62643.1 598 2.2e-59 unknown [Dendroctonus ponderosae]>gi|478258425|gb|ENN78519.1| hypothetical protein YQE_05012, partial [Dendroctonus ponderosae]>gi|546676434|gb|ERL87445.1| hypothetical protein D910_04837 [Dendroctonus ponderosae] -- -- -- -- -- K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 268 1.7e-22 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 PF02936 Cytochrome c oxidase subunit IV GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.34229 BP_3 152.60 1.00 7670 642938169 XP_008190998.1 1045 3.3e-110 PREDICTED: G-protein coupled receptor Mth2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NQ0 440 2.0e-41 G-protein coupled receptor Mth2 OS=Drosophila simulans GN=mth2 PE=3 SV=1 PF00002//PF06652//PF00001//PF04644 7 transmembrane receptor (Secretin family)//Methuselah N-terminus//7 transmembrane receptor (rhodopsin family)//Motilin/ghrelin GO:0007165//GO:0007186//GO:0006950 signal transduction//G-protein coupled receptor signaling pathway//response to stress GO:0004930//GO:0005179 G-protein coupled receptor activity//hormone activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.3423 BP_3 49.00 2.09 1420 91080329 XP_974555.1 1129 1.1e-120 PREDICTED: mitochondrial ornithine transporter 1 [Tribolium castaneum]>gi|270005604|gb|EFA02052.1| hypothetical protein TcasGA2_TC007680 [Tribolium castaneum] -- -- -- -- -- K15101 SLC25A2_15, ORNT solute carrier family 25 (mitochondrial ornithine transporter) member 2/15 http://www.genome.jp/dbget-bin/www_bget?ko:K15101 Q9Y619 683 2.4e-70 Mitochondrial ornithine transporter 1 OS=Homo sapiens GN=SLC25A15 PE=1 SV=1 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG0758 Mitochondrial carnitine-acylcarnitine carrier protein Cluster-8309.34230 BP_3 469.97 3.92 6065 91080927 XP_974039.1 6560 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3107 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF04183//PF02207//PF02617//PF01599 IucA / IucC family//Putative zinc finger in N-recognin (UBR box)//ATP-dependent Clp protease adaptor protein ClpS//Ribosomal protein S27a GO:0016567//GO:0006412//GO:0019290//GO:0006826//GO:0030163//GO:0042254 protein ubiquitination//translation//siderophore biosynthetic process//iron ion transport//protein catabolic process//ribosome biogenesis GO:0004842//GO:0015343//GO:0008270//GO:0003735 ubiquitin-protein transferase activity//siderophore transmembrane transporter activity//zinc ion binding//structural constituent of ribosome GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.34232 BP_3 135.82 1.06 6460 642938175 XP_008191019.1 799 9.4e-82 PREDICTED: G-protein coupled receptor Mth2-like isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 333 4.2e-29 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF04644//PF00002 Motilin/ghrelin//7 transmembrane receptor (Secretin family) GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0004930//GO:0005179 G-protein coupled receptor activity//hormone activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.34234 BP_3 17.00 3.77 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34236 BP_3 17.00 0.92 1178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34237 BP_3 25.13 0.31 4249 478253163 ENN73534.1 187 5.7e-11 hypothetical protein YQE_09785, partial [Dendroctonus ponderosae] -- -- -- -- -- K09370 ISL1 insulin gene enhancer protein ISL-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09370 P61371 178 2.6e-11 Insulin gene enhancer protein ISL-1 OS=Homo sapiens GN=ISL1 PE=1 SV=1 PF02701//PF13465//PF00412//PF02892//PF05495//PF00096//PF00046//PF05920 Dof domain, zinc finger//Zinc-finger double domain//LIM domain//BED zinc finger//CHY zinc finger//Zinc finger, C2H2 type//Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding -- -- KOG4577 Transcription factor LIM3, contains LIM and HOX domains Cluster-8309.34241 BP_3 30.94 0.71 2398 357605001 EHJ64416.1 1263 5.5e-136 putative mitochondrial solute carrier [Danaus plexippus] -- -- -- -- -- K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q9VA73 1209 4.1e-131 Calcium-binding mitochondrial carrier protein Aralar1 OS=Drosophila melanogaster GN=aralar1 PE=2 SV=1 PF13833 EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.34242 BP_3 219.00 18.91 850 642913424 XP_008201005.1 193 2.3e-12 PREDICTED: calcium-binding mitochondrial carrier protein Aralar1 [Tribolium castaneum] -- -- -- -- -- K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q21153 156 1.8e-09 Probable calcium-binding mitochondrial carrier K02F3.2 OS=Caenorhabditis elegans GN=K02F3.2 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.34243 BP_3 261.19 15.52 1103 189237141 XP_973425.2 674 5.0e-68 PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like isoform X2 [Tribolium castaneum] 665410487 NM_176340.3 35 1.71369e-06 Drosophila melanogaster neural conserved at 73EF (Nc73EF), transcript variant F, mRNA K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q6P6Z8 323 1.0e-28 2-oxoglutarate dehydrogenase, mitochondrial OS=Xenopus laevis GN=ogdh PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.34244 BP_3 3.00 0.36 689 478251302 ENN71770.1 174 3.0e-10 hypothetical protein YQE_11505, partial [Dendroctonus ponderosae]>gi|546678660|gb|ERL89232.1| hypothetical protein D910_06606 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34245 BP_3 655.89 7.64 4430 478252433 ENN72856.1 1892 1.2e-208 hypothetical protein YQE_10505, partial [Dendroctonus ponderosae]>gi|478264876|gb|ENN82355.1| hypothetical protein YQE_01270, partial [Dendroctonus ponderosae] 157136696 XM_001656830.1 41 3.25207e-09 Aedes aegypti AAEL013617-RA partial mRNA -- -- -- -- P52757 923 1.1e-97 Beta-chimaerin OS=Homo sapiens GN=CHN2 PE=1 SV=2 PF00130//PF00620//PF04434//PF01363 Phorbol esters/diacylglycerol binding domain (C1 domain)//RhoGAP domain//SWIM zinc finger//FYVE zinc finger GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.34246 BP_3 2561.18 12.42 10231 642911435 XP_008199422.1 2703 2.5e-302 PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911437|ref|XP_008199423.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911439|ref|XP_008199424.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum] -- -- -- -- -- K01349 FURIN, PCSK3 furin http://www.genome.jp/dbget-bin/www_bget?ko:K01349 P30430 1976 2.0e-219 Furin-like protease 1, isoform 1-CRR OS=Drosophila melanogaster GN=Fur1 PE=2 SV=2 PF08496//PF00082//PF09458//PF01483 Peptidase family S49 N-terminal//Subtilase family//H-type lectin domain//Proprotein convertase P-domain GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252//GO:0030246 serine-type endopeptidase activity//carbohydrate binding GO:0005886 plasma membrane KOG3525 Subtilisin-like proprotein convertase Cluster-8309.34247 BP_3 93.15 2.07 2459 478256664 ENN76846.1 1026 1.7e-108 hypothetical protein YQE_06687, partial [Dendroctonus ponderosae]>gi|546685138|gb|ERL94665.1| hypothetical protein D910_11940 [Dendroctonus ponderosae] 815782412 XM_012359088.1 110 7.89006e-48 PREDICTED: Linepithema humile adenylate kinase (LOC105667343), mRNA K00939 adk, AK adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00939 Q9U915 954 1.6e-101 Adenylate kinase OS=Drosophila melanogaster GN=Adk2 PE=1 SV=1 PF02224//PF02892//PF05191 Cytidylate kinase//BED zinc finger//Adenylate kinase, active site lid GO:0006206//GO:0006139//GO:0046034//GO:0006144 pyrimidine nucleobase metabolic process//nucleobase-containing compound metabolic process//ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0004127//GO:0003677//GO:0005524 adenylate kinase activity//cytidylate kinase activity//DNA binding//ATP binding -- -- KOG3078 Adenylate kinase Cluster-8309.34248 BP_3 619.19 14.28 2381 478256664 ENN76846.1 1026 1.7e-108 hypothetical protein YQE_06687, partial [Dendroctonus ponderosae]>gi|546685138|gb|ERL94665.1| hypothetical protein D910_11940 [Dendroctonus ponderosae] 815782412 XM_012359088.1 110 7.63618e-48 PREDICTED: Linepithema humile adenylate kinase (LOC105667343), mRNA K00939 adk, AK adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00939 Q9U915 954 1.5e-101 Adenylate kinase OS=Drosophila melanogaster GN=Adk2 PE=1 SV=1 PF05191//PF02892//PF02224 Adenylate kinase, active site lid//BED zinc finger//Cytidylate kinase GO:0006139//GO:0046034//GO:0006144//GO:0006206 nucleobase-containing compound metabolic process//ATP metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0005524//GO:0004017//GO:0004127 DNA binding//ATP binding//adenylate kinase activity//cytidylate kinase activity -- -- KOG3078 Adenylate kinase Cluster-8309.34249 BP_3 404.00 23.60 1117 91081671 XP_969903.1 758 9.2e-78 PREDICTED: malignant T-cell-amplified sequence 1-A [Tribolium castaneum]>gi|270006240|gb|EFA02688.1| hypothetical protein TcasGA2_TC008409 [Tribolium castaneum] -- -- -- -- -- K07575 K07575 PUA domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K07575 Q9W445 624 1.3e-63 Malignant T-cell-amplified sequence 1 homolog OS=Drosophila melanogaster GN=MCTS1 PE=1 SV=1 PF01472 PUA domain -- -- GO:0003723 RNA binding -- -- KOG2523 Predicted RNA-binding protein with PUA domain Cluster-8309.3425 BP_3 48.40 2.51 1222 642923225 XP_008193663.1 759 7.7e-78 PREDICTED: ribonuclease P protein subunit p30 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P78346 265 6.1e-22 Ribonuclease P protein subunit p30 OS=Homo sapiens GN=RPP30 PE=1 SV=1 PF01876 RNase P subunit p30 GO:0051252//GO:0008033 regulation of RNA metabolic process//tRNA processing GO:0004540 ribonuclease activity -- -- KOG2363 Protein subunit of nuclear ribonuclease P (RNase P) Cluster-8309.34250 BP_3 36.68 1.10 1902 642915291 XP_008190557.1 1102 2.0e-117 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 768 4.5e-80 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF10410//PF02985//PF00311//PF01602 DnaB-helicase binding domain of primase//HEAT repeat//Phosphoenolpyruvate carboxylase//Adaptin N terminal region GO:0015977//GO:0019643//GO:0006886//GO:0016192//GO:0006094//GO:0006099 carbon fixation//reductive tricarboxylic acid cycle//intracellular protein transport//vesicle-mediated transport//gluconeogenesis//tricarboxylic acid cycle GO:0008964//GO:0005515//GO:0016779 phosphoenolpyruvate carboxylase activity//protein binding//nucleotidyltransferase activity GO:0030117 membrane coat -- -- Cluster-8309.34252 BP_3 284.88 4.34 3457 642935594 XP_008198075.1 2999 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I isoform X13 [Tribolium castaneum] 642935593 XM_008199853.1 1016 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X15, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 Q9W4T4 2498 2.0e-280 cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I OS=Drosophila melanogaster GN=dnc PE=1 SV=2 PF07469//PF00233 Domain of unknown function (DUF1518)//3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.34253 BP_3 946.18 10.25 4742 478255214 ENN75443.1 905 3.5e-94 hypothetical protein YQE_07994, partial [Dendroctonus ponderosae]>gi|546675119|gb|ERL86366.1| hypothetical protein D910_03774 [Dendroctonus ponderosae] 805772222 XM_012281473.1 98 7.17508e-41 PREDICTED: Megachile rotundata probable protein phosphatase CG10417 (LOC100882395), mRNA K17499 PPM1G, PP2CG protein phosphatase 1G http://www.genome.jp/dbget-bin/www_bget?ko:K17499 Q7K4Q5 760 9.5e-79 Probable protein phosphatase CG10417 OS=Drosophila melanogaster GN=CG10417 PE=1 SV=1 PF00481//PF01251//PF07228 Protein phosphatase 2C//Ribosomal protein S7e//Stage II sporulation protein E (SpoIIE) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0698 Serine/threonine protein phosphatase Cluster-8309.34254 BP_3 368.26 22.81 1070 642924642 XP_008194376.1 626 1.8e-62 PREDICTED: tensin isoform X2 [Tribolium castaneum] -- -- -- -- -- K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 -- -- -- -- PF00130//PF01688 Phorbol esters/diacylglycerol binding domain (C1 domain)//Alphaherpesvirus glycoprotein I GO:0035556 intracellular signal transduction -- -- GO:0043657 host cell -- -- Cluster-8309.34255 BP_3 14.84 0.39 2141 270013857 EFA10305.1 172 1.6e-09 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13181 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34257 BP_3 1577.00 155.04 782 91077486 XP_968733.1 780 1.8e-80 PREDICTED: ATP synthase subunit O, mitochondrial [Tribolium castaneum]>gi|270002753|gb|EEZ99200.1| oligomycin sensitivity-conferring protein [Tribolium castaneum] -- -- -- -- -- K02137 ATPeF0O, ATP5O, ATP5 F-type H+-transporting ATPase subunit O http://www.genome.jp/dbget-bin/www_bget?ko:K02137 Q24439 605 1.5e-61 ATP synthase subunit O, mitochondrial OS=Drosophila melanogaster GN=Oscp PE=2 SV=2 PF00213 ATP synthase delta (OSCP) subunit GO:0015986 ATP synthesis coupled proton transport GO:0046933 proton-transporting ATP synthase activity, rotational mechanism GO:0045259 proton-transporting ATP synthase complex KOG1662 Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 Cluster-8309.34259 BP_3 61.27 1.66 2076 642921732 XP_008199304.1 436 3.7e-40 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 338 3.6e-30 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.34260 BP_3 67.73 0.83 4221 642923755 XP_008193870.1 933 1.8e-97 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 574 3.1e-57 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- GO:0051302//GO:0051726//GO:0045859 regulation of cell division//regulation of cell cycle//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.34261 BP_3 159.70 1.44 5651 642923755 XP_008193870.1 936 1.1e-97 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 1.2e-56 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- GO:0045859//GO:0051302//GO:0051726 regulation of protein kinase activity//regulation of cell division//regulation of cell cycle GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.34262 BP_3 288.97 2.58 5693 642923755 XP_008193870.1 936 1.1e-97 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 1.2e-56 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- GO:0051302//GO:0051726//GO:0045859 regulation of cell division//regulation of cell cycle//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.34265 BP_3 659.51 21.12 1797 642915949 XP_967806.3 1385 2.9e-150 PREDICTED: protein halfway isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 863 4.1e-91 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF15549//PF13855//PF00560 PGC7/Stella/Dppa3 domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0035064//GO:0005515 methylated histone binding//protein binding -- -- -- -- Cluster-8309.34266 BP_3 1014.00 46.54 1342 91088601 XP_973643.1 1864 6.3e-206 PREDICTED: 26S proteasome non-ATPase regulatory subunit 6 [Tribolium castaneum]>gi|270012256|gb|EFA08704.1| hypothetical protein TcasGA2_TC006375 [Tribolium castaneum] 632955242 XM_007895182.1 74 4.37636e-28 PREDICTED: Callorhinchus milii proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (psmd6), mRNA K03037 PSMD6, RPN7 26S proteasome regulatory subunit N7 http://www.genome.jp/dbget-bin/www_bget?ko:K03037 Q9V3G7 1486 1.8e-163 26S proteasome non-ATPase regulatory subunit 6 OS=Drosophila melanogaster GN=Rpn7 PE=2 SV=1 PF13181//PF01399//PF13176 Tetratricopeptide repeat//PCI domain//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0687 26S proteasome regulatory complex, subunit RPN7/PSMD6 Cluster-8309.34267 BP_3 202.91 4.72 2364 546673188 ERL84846.1 773 3.6e-79 hypothetical protein D910_02270 [Dendroctonus ponderosae] -- -- -- -- -- K07910 RAB18 Ras-related protein Rab-18 http://www.genome.jp/dbget-bin/www_bget?ko:K07910 Q5ZLG1 643 1.7e-65 Ras-related protein Rab-18 OS=Gallus gallus GN=RAB18 PE=2 SV=1 PF00005//PF03193//PF04670//PF00071//PF00076//PF07475//PF01926//PF07728//PF00735//PF08477//PF00025 ABC transporter//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//HPr Serine kinase C-terminal domain//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family GO:0000160//GO:0016310//GO:0006109//GO:0007264 phosphorelay signal transduction system//phosphorylation//regulation of carbohydrate metabolic process//small GTPase mediated signal transduction GO:0005524//GO:0000155//GO:0003924//GO:0005525//GO:0003676//GO:0016887//GO:0004672 ATP binding//phosphorelay sensor kinase activity//GTPase activity//GTP binding//nucleic acid binding//ATPase activity//protein kinase activity GO:0009365 protein histidine kinase complex KOG0080 GTPase Rab18, small G protein superfamily Cluster-8309.34268 BP_3 1612.71 96.89 1094 91086693 XP_969563.1 542 1.0e-52 PREDICTED: 12 kDa FK506-binding protein [Tribolium castaneum]>gi|270010405|gb|EFA06853.1| hypothetical protein TcasGA2_TC009796 [Tribolium castaneum] -- -- -- -- -- K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 P18203 475 2.4e-46 Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Bos taurus GN=FKBP1A PE=1 SV=2 PF01581//PF00254 FMRFamide related peptide family//FKBP-type peptidyl-prolyl cis-trans isomerase GO:0006457//GO:0007218//GO:0000413 protein folding//neuropeptide signaling pathway//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.34270 BP_3 18.00 1.54 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF08107 Arthropod defensin//Pleurocidin family GO:0042742//GO:0006952 defense response to bacterium//defense response -- -- -- -- -- -- Cluster-8309.34273 BP_3 21.06 0.81 1552 478251391 ENN71857.1 247 2.3e-18 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 O74803 186 1.1e-12 UV excision repair protein rhp23 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rhp23 PE=1 SV=1 PF09280//PF00995 XPC-binding domain//Sec1 family GO:0016192//GO:0043161//GO:0006281//GO:0006904//GO:0006289 vesicle-mediated transport//proteasome-mediated ubiquitin-dependent protein catabolic process//DNA repair//vesicle docking involved in exocytosis//nucleotide-excision repair GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.34276 BP_3 12.12 0.39 1801 546684637 ERL94254.1 1892 4.8e-209 hypothetical protein D910_11535 [Dendroctonus ponderosae] 676425561 XM_009046107.1 164 5.5094e-78 Lottia gigantea hypothetical protein partial mRNA K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 Q8HXY7 1561 4.7e-172 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Macaca fascicularis GN=ACADVL PE=2 SV=1 PF02770//PF00441//PF02771 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0008152//GO:0006118 oxidation-reduction process//metabolic process//obsolete electron transport GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity -- -- KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.34278 BP_3 120.93 3.52 1949 270011937 EFA08385.1 1820 1.2e-200 hypothetical protein TcasGA2_TC006029 [Tribolium castaneum] -- -- -- -- -- K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 1338 3.7e-146 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF11744//PF01207 Aluminium activated malate transporter//Dihydrouridine synthase (Dus) GO:0055114//GO:0015743//GO:0008033 oxidation-reduction process//malate transport//tRNA processing GO:0017150//GO:0050660 tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.34279 BP_3 1120.01 12.48 4617 642910583 XP_008200013.1 3042 0.0e+00 PREDICTED: cap-n-collar isoform X4 [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 6.6e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF03131//PF03126//PF00170//PF07716 bZIP Maf transcription factor//Plus-3 domain//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3863 bZIP transcription factor NRF1 Cluster-8309.3428 BP_3 25.00 1.32 1203 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34280 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34281 BP_3 2468.71 43.68 3016 332376933 AEE63606.1 1622 1.6e-177 unknown [Dendroctonus ponderosae] 827538802 XM_012696885.1 74 9.97511e-28 PREDICTED: Bombyx mori phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (LOC101743489), transcript variant X3, mRNA K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 Q01604 1393 2.4e-152 Phosphoglycerate kinase OS=Drosophila melanogaster GN=Pgk PE=2 SV=2 PF00162//PF00069 Phosphoglycerate kinase//Protein kinase domain GO:0015976//GO:0006094//GO:0006096//GO:0006468//GO:0016310 carbon utilization//gluconeogenesis//glycolytic process//protein phosphorylation//phosphorylation GO:0004672//GO:0005524//GO:0004618 protein kinase activity//ATP binding//phosphoglycerate kinase activity -- -- KOG1367 3-phosphoglycerate kinase Cluster-8309.34282 BP_3 766.13 8.97 4407 91082905 XP_972330.1 2058 6.6e-228 PREDICTED: eukaryotic translation initiation factor 2A [Tribolium castaneum]>gi|270007067|gb|EFA03515.1| hypothetical protein TcasGA2_TC013517 [Tribolium castaneum] -- -- -- -- -- K15026 EIF2A translation initiation factor 2A http://www.genome.jp/dbget-bin/www_bget?ko:K15026 Q7ZY11 1191 9.3e-129 Eukaryotic translation initiation factor 2A OS=Xenopus laevis GN=eif2a PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.34283 BP_3 103.71 3.67 1653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34286 BP_3 277.00 20.66 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34287 BP_3 113.78 0.86 6659 642914575 XP_971897.2 4166 0.0e+00 PREDICTED: insulin-degrading enzyme [Tribolium castaneum] -- -- -- -- -- K01408 IDE, ide insulysin http://www.genome.jp/dbget-bin/www_bget?ko:K01408 Q24K02 2825 0.0e+00 Insulin-degrading enzyme OS=Bos taurus GN=IDE PE=2 SV=1 PF14560 Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.34288 BP_3 291.16 7.92 2064 546682276 ERL92237.1 1300 2.4e-140 hypothetical protein D910_09554 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5BKL1 595 5.6e-60 UPF0415 protein C7orf25 homolog OS=Xenopus tropicalis GN=TGas015c11.1 PE=2 SV=1 PF04987 Phosphatidylinositolglycan class N (PIG-N) GO:0006506 GPI anchor biosynthetic process GO:0016740 transferase activity GO:0005789 endoplasmic reticulum membrane KOG4529 Uncharacterized conserved protein Cluster-8309.3429 BP_3 3.00 0.45 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34290 BP_3 2936.97 29.92 5023 642915428 XP_008190611.1 5803 0.0e+00 PREDICTED: clustered mitochondria protein homolog [Tribolium castaneum]>gi|270004006|gb|EFA00454.1| hypothetical protein TcasGA2_TC003310 [Tribolium castaneum] 571519225 XM_006563927.1 413 0 PREDICTED: Apis mellifera protein KIAA0664 homolog (LOC552519), transcript variant X1, mRNA K03255 TIF31, CLU1 protein TIF31 http://www.genome.jp/dbget-bin/www_bget?ko:K03255 Q17N71 4738 0.0e+00 Clustered mitochondria protein homolog OS=Aedes aegypti GN=AAEL000794 PE=3 SV=1 PF13181//PF13374//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG1839 Uncharacterized protein CLU1/cluA/TIF31 involved in mitochondrial morphology/distribution, also found associated with eIF-3 Cluster-8309.34291 BP_3 92.64 3.24 1669 332372728 AEE61506.1 1350 3.1e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K18660 ACSF3 malonyl-CoA/methylmalonyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K18660 Q6GLK6 706 6.1e-73 Acyl-CoA synthetase family member 3, mitochondrial OS=Xenopus laevis GN=acsf3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.34292 BP_3 683.00 57.33 866 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34293 BP_3 265.46 4.76 2981 546677419 ERL88256.1 1003 9.6e-106 hypothetical protein D910_05644 [Dendroctonus ponderosae] -- -- -- -- -- K18660 ACSF3 malonyl-CoA/methylmalonyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K18660 Q3URE1 634 2.4e-64 Acyl-CoA synthetase family member 3, mitochondrial OS=Mus musculus GN=Acsf3 PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.34294 BP_3 412.44 8.32 2682 332374778 AEE62530.1 3000 0.0e+00 unknown [Dendroctonus ponderosae]>gi|478257113|gb|ENN77276.1| hypothetical protein YQE_06103, partial [Dendroctonus ponderosae]>gi|546683351|gb|ERL93173.1| hypothetical protein D910_10470 [Dendroctonus ponderosae] 264667372 GU120422.1 126 1.09812e-56 Chrysomela tremulae ribosomal protein S18 (RpS18) mRNA, complete cds -- -- -- -- Q5TJF0 1789 2.6e-198 Vacuolar protein sorting-associated protein 52 homolog OS=Canis familiaris GN=VPS52 PE=3 SV=1 PF08716//PF00416//PF05192 nsp7 replicase//Ribosomal protein S13/S18//MutS domain III GO:0006412//GO:0006298//GO:0042254//GO:0006508 translation//mismatch repair//ribosome biogenesis//proteolysis GO:0008242//GO:0016740//GO:0003723//GO:0005524//GO:0004197//GO:0030983//GO:0003735 omega peptidase activity//transferase activity//RNA binding//ATP binding//cysteine-type endopeptidase activity//mismatched DNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1961 Vacuolar sorting protein VPS52/suppressor of actin Sac2 Cluster-8309.34295 BP_3 1452.43 81.00 1156 642931531 XP_008196624.1 391 3.4e-35 PREDICTED: 28 kDa heat- and acid-stable phosphoprotein-like [Tribolium castaneum]>gi|270011801|gb|EFA08249.1| hypothetical protein TcasGA2_TC005877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UHX2 193 1.3e-13 28 kDa heat- and acid-stable phosphoprotein OS=Mus musculus GN=Pdap1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3375 Phosphoprotein/predicted coiled-coil protein Cluster-8309.34296 BP_3 3.00 5.06 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.343 BP_3 4.00 0.39 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34300 BP_3 100.82 1.71 3136 268370140 NP_001161251.1 1811 2.0e-199 uncharacterized protein LOC100141687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWK7 159 3.1e-09 RING finger protein 145 OS=Mus musculus GN=Rnf145 PE=2 SV=1 PF17123//PF12678//PF12861//PF14634//PF00097//PF11789//PF13639 RING-like zinc finger//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Ring finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//metal ion binding//protein binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.34303 BP_3 850.76 14.75 3072 91084169 XP_971096.1 2333 5.9e-260 PREDICTED: alpha-1,2-mannosyltransferase ALG9 [Tribolium castaneum]>gi|270006637|gb|EFA03085.1| hypothetical protein TcasGA2_TC012991 [Tribolium castaneum] -- -- -- -- -- K03846 ALG9 alpha-1,2-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03846 Q8VDI9 1411 2.0e-154 Alpha-1,2-mannosyltransferase ALG9 OS=Mus musculus GN=Alg9 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2515 Mannosyltransferase Cluster-8309.34304 BP_3 828.26 12.42 3506 270002756 EEZ99203.1 1025 3.2e-108 serine protease P8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 670 1.9e-68 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34305 BP_3 1052.77 31.71 1892 642935333 XP_008197972.1 674 8.6e-68 PREDICTED: uncharacterized protein LOC100142013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 412 8.5e-39 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 PF02170 PAZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34311 BP_3 79.16 0.47 8357 546676129 ERL87196.1 501 4.4e-47 hypothetical protein D910_04595 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34312 BP_3 3287.00 250.58 924 91093965 XP_968405.1 512 2.6e-49 PREDICTED: epididymal secretory protein E1 [Tribolium castaneum]>gi|270011130|gb|EFA07578.1| hypothetical protein TcasGA2_TC016351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61916 194 7.9e-14 Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34314 BP_3 353.13 5.01 3686 91078854 XP_971956.1 810 2.8e-83 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit C [Tribolium castaneum]>gi|270004131|gb|EFA00579.1| hypothetical protein TcasGA2_TC003449 [Tribolium castaneum] 242023017 XM_002431888.1 35 5.84756e-06 Pediculus humanus corporis Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative, mRNA K03859 PIGC, GPI2 phosphatidylinositol glycan, class C http://www.genome.jp/dbget-bin/www_bget?ko:K03859 Q92535 456 1.3e-43 Phosphatidylinositol N-acetylglucosaminyltransferase subunit C OS=Homo sapiens GN=PIGC PE=2 SV=1 PF01158//PF06432 Ribosomal protein L36e//Phosphatidylinositol N-acetylglucosaminyltransferase GO:0006412//GO:0006506//GO:0042254 translation//GPI anchor biosynthetic process//ribosome biogenesis GO:0017176//GO:0003735 phosphatidylinositol N-acetylglucosaminyltransferase activity//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622 integral component of membrane//ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-8309.34316 BP_3 5029.05 25.07 9959 546672491 ERL84327.1 5266 0.0e+00 hypothetical protein D910_01746, partial [Dendroctonus ponderosae] 642918533 XM_008193290.1 175 2.37451e-83 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- O01761 764 6.8e-79 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF13897//PF02480 Immunoglobulin domain//Golgi-dynamics membrane-trafficking//Alphaherpesvirus glycoprotein E GO:0006810 transport GO:0005515 protein binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.34318 BP_3 25.00 0.62 2248 642916176 XP_008190917.1 2269 1.1e-252 PREDICTED: transcription factor 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BQ70 1107 2.6e-119 Transcription factor 25 OS=Homo sapiens GN=TCF25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2422 Uncharacterized conserved protein Cluster-8309.34320 BP_3 184.04 1.29 7147 642919008 XP_008191694.1 4125 0.0e+00 PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum]>gi|642919010|ref|XP_008191695.1| PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum] 742179525 XM_010889443.1 55 8.67913e-17 PREDICTED: Esox lucius adenylate cyclase 9 (adcy9), transcript variant X2, mRNA K08049 ADCY9 adenylate cyclase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08049 P51830 1008 2.5e-107 Adenylate cyclase type 9 OS=Mus musculus GN=Adcy9 PE=1 SV=1 PF06327//PF07701//PF00211 Domain of Unknown Function (DUF1053)//Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0006144//GO:0006171 cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//purine nucleobase metabolic process//cAMP biosynthetic process GO:0004383//GO:0016849//GO:0004016 guanylate cyclase activity//phosphorus-oxygen lyase activity//adenylate cyclase activity GO:0005886 plasma membrane KOG3618 Adenylyl cyclase Cluster-8309.34321 BP_3 11469.76 53.53 10619 642913459 XP_008201021.1 2877 0.0e+00 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] 642913458 XM_008202799.1 192 8.98037e-93 PREDICTED: Tribolium castaneum uncharacterized LOC103315067 (LOC103315067), mRNA K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q9VAN0 1068 4.1e-114 Probable phosphoserine aminotransferase OS=Drosophila melanogaster GN=CG11899 PE=2 SV=1 PF03334//PF03581//PF03169 Na+/H+ antiporter subunit//Herpesvirus UL33-like protein//OPT oligopeptide transporter protein GO:0015672//GO:0055085//GO:0015992//GO:0019073 monovalent inorganic cation transport//transmembrane transport//proton transport//viral DNA genome packaging GO:0005451 monovalent cation:proton antiporter activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.34322 BP_3 171.99 11.79 995 642915041 XP_008190385.1 562 4.4e-55 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like [Tribolium castaneum] -- -- -- -- -- K08059 IFI30, GILT interferon, gamma-inducible protein 30 http://www.genome.jp/dbget-bin/www_bget?ko:K08059 A6QPN6 281 6.9e-24 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.34323 BP_3 31.45 0.86 2053 189240075 XP_001812636.1 1261 8.0e-136 PREDICTED: protein singed wings 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SXT3 593 9.5e-60 Protein singed wings 2 OS=Drosophila melanogaster GN=swi2 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34326 BP_3 2.00 7.85 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34327 BP_3 11.61 0.31 2109 189242016 XP_001807518.1 1879 1.8e-207 PREDICTED: carboxypeptidase E-like [Tribolium castaneum] 37787288 AY214171.1 41 1.53548e-09 Paralichthys olivaceus carboxypeptidase H mRNA, complete cds K01294 CPE carboxypeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01294 P37892 1035 5.4e-111 Carboxypeptidase E OS=Lophius americanus GN=cpe PE=2 SV=1 PF00246//PF04952 Zinc carboxypeptidase//Succinylglutamate desuccinylase / Aspartoacylase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004181//GO:0008270//GO:0016788 metallocarboxypeptidase activity//zinc ion binding//hydrolase activity, acting on ester bonds -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.34329 BP_3 2446.60 88.18 1629 642935043 XP_969003.2 1763 3.9e-194 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [Tribolium castaneum] -- -- -- -- -- K12670 WBP1 oligosaccharyltransferase complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12670 Q24319 1462 1.3e-160 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Drosophila melanogaster GN=Ost48 PE=2 SV=2 PF03345 Oligosaccharyltransferase 48 kDa subunit beta GO:0018279 protein N-linked glycosylation via asparagine -- -- GO:0005789 endoplasmic reticulum membrane KOG2754 Oligosaccharyltransferase, beta subunit Cluster-8309.34333 BP_3 6.00 0.54 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34335 BP_3 1297.95 26.19 2680 91077358 XP_975083.1 383 6.8e-34 PREDICTED: protein spaetzle isoform X2 [Tribolium castaneum]>gi|642913850|ref|XP_008201187.1| PREDICTED: protein spaetzle isoform X1 [Tribolium castaneum]>gi|642913852|ref|XP_008201188.1| PREDICTED: protein spaetzle isoform X1 [Tribolium castaneum]>gi|270002760|gb|EEZ99207.1| spaetzle [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48607 219 2.9e-16 Protein spaetzle OS=Drosophila melanogaster GN=spz PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34336 BP_3 11.00 0.33 1885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34337 BP_3 7.00 0.93 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3434 BP_3 15.00 0.46 1871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15149 Cation channel sperm-associated protein subunit beta protein family -- -- -- -- GO:0036128 CatSper complex -- -- Cluster-8309.34345 BP_3 433.35 7.25 3172 642929001 XP_008195650.1 2752 1.6e-308 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 999 1.2e-106 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF05986//PF08686 ADAM-TS Spacer 1//PLAC (protease and lacunin) domain -- -- GO:0004222//GO:0008233 metalloendopeptidase activity//peptidase activity GO:0031012 extracellular matrix KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.34347 BP_3 190.61 1.41 6812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00894//PF00641 Luteovirus coat protein//Zn-finger in Ran binding protein and others -- -- GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.34348 BP_3 699.00 19.49 2020 189239065 XP_971190.2 918 4.7e-96 PREDICTED: putative phosphatidate phosphatase isoform X1 [Tribolium castaneum]>gi|270010853|gb|EFA07301.1| hypothetical protein TcasGA2_TC015891 [Tribolium castaneum] 817069832 XM_012401489.1 36 8.84467e-07 PREDICTED: Athalia rosae putative phosphatidate phosphatase (LOC105686556), mRNA K01080 PPAP2 phosphatidate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01080 Q9V576 693 2.4e-71 Putative phosphatidate phosphatase OS=Drosophila melanogaster GN=wun PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3030 Lipid phosphate phosphatase and related enzymes of the PAP2 family Cluster-8309.34349 BP_3 77.00 9.18 696 332372472 AEE61378.1 708 3.6e-72 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00020 E1.1.1.31, mmsB 3-hydroxyisobutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00020 P31937 596 1.4e-60 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2 PF14833//PF03446 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0006098//GO:0019521 oxidation-reduction process//pentose-phosphate shunt//D-gluconate metabolic process GO:0051287//GO:0004616 NAD binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG0409 Predicted dehydrogenase Cluster-8309.3435 BP_3 5.00 0.31 1072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03127 GAT domain GO:0006886 intracellular protein transport -- -- GO:0005622 intracellular -- -- Cluster-8309.34350 BP_3 1091.00 54.25 1261 189241537 XP_970292.2 1695 2.3e-186 PREDICTED: tropomodulin isoform X2 [Tribolium castaneum] 642936890 XR_511484.1 397 0 PREDICTED: Tribolium castaneum tropomodulin (LOC658846), transcript variant X2, misc_RNA K10370 TMOD tropomodulin http://www.genome.jp/dbget-bin/www_bget?ko:K10370 O01479 645 5.4e-66 Tropomodulin OS=Caenorhabditis elegans GN=unc-94 PE=1 SV=2 PF03250 Tropomodulin GO:0051694 pointed-end actin filament capping GO:0005523 tropomyosin binding -- -- KOG3735 Tropomodulin and leiomodulin Cluster-8309.34353 BP_3 35.38 1.00 2004 642930397 XP_008196382.1 1526 1.5e-166 PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930399|ref|XP_008196383.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930401|ref|XP_008196384.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|270010720|gb|EFA07168.1| hypothetical protein TcasGA2_TC010167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7JUY7 636 9.6e-65 PTB domain-containing adapter protein ced-6 OS=Drosophila melanogaster GN=ced-6 PE=1 SV=1 PF00640//PF08416//PF14719 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG3536 Adaptor protein CED-6, contains PTB domain Cluster-8309.34354 BP_3 1223.31 6.42 9474 642922513 XP_008193205.1 10415 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase hyd isoform X4 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.424e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1848 1.3e-204 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF04625//PF00658//PF00632//PF11547 DEC-1 protein, N-terminal region//Poly-adenylate binding protein, unique domain//HECT-domain (ubiquitin-transferase)//E3 ubiquitin ligase EDD GO:0007304//GO:0016567 chorion-containing eggshell formation//protein ubiquitination GO:0043130//GO:0005213//GO:0003723//GO:0004842 ubiquitin binding//structural constituent of chorion//RNA binding//ubiquitin-protein transferase activity GO:0005576//GO:0042600 extracellular region//chorion KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.34355 BP_3 631.43 15.63 2239 642923934 XP_969778.3 1124 6.7e-120 PREDICTED: choline-phosphate cytidylyltransferase A-like isoform X2 [Tribolium castaneum]>gi|270006886|gb|EFA03334.1| hypothetical protein TcasGA2_TC013311 [Tribolium castaneum] -- -- -- -- -- K00968 PCYT1 choline-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00968 P49585 756 1.3e-78 Choline-phosphate cytidylyltransferase A OS=Homo sapiens GN=PCYT1A PE=1 SV=2 PF06574//PF01467 FAD synthetase//Cytidylyltransferase-like GO:0009058//GO:0009231//GO:0006771 biosynthetic process//riboflavin biosynthetic process//riboflavin metabolic process GO:0003919//GO:0003824 FMN adenylyltransferase activity//catalytic activity -- -- KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-8309.34357 BP_3 659.54 62.30 802 642932804 XP_008196990.1 639 4.2e-64 PREDICTED: myosin heavy chain, non-muscle isoform X1 [Tribolium castaneum] -- -- -- -- -- K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 444 7.0e-43 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF00063//PF02736 Myosin head (motor domain)//Myosin N-terminal SH3-like domain -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.34358 BP_3 430.98 4.56 4845 91084547 XP_973113.1 3577 0.0e+00 PREDICTED: protein unc-45 homolog B [Tribolium castaneum]>gi|270009248|gb|EFA05696.1| translocase of outer membrane 34 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F64 1674 1.0e-184 Protein unc-45 homolog B OS=Xenopus laevis GN=unc45b PE=2 SV=1 PF00515//PF13374//PF13371//PF08718//PF03152//PF13176//PF13414//PF13181//PF00839//PF00514 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Glycolipid transfer protein (GLTP)//Ubiquitin fusion degradation protein UFD1//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Cysteine rich repeat//Armadillo/beta-catenin-like repeat GO:0046836//GO:0006511 glycolipid transport//ubiquitin-dependent protein catabolic process GO:0005515//GO:0051861//GO:0017089 protein binding//glycolipid binding//glycolipid transporter activity GO:0005737//GO:0016020 cytoplasm//membrane KOG1816 Ubiquitin fusion-degradation protein Cluster-8309.34359 BP_3 2436.70 132.67 1177 820805538 AKG92760.1 637 1.0e-63 extra macrochaetae [Leptinotarsa decemlineata] 195428687 XM_002062365.1 43 6.53595e-11 Drosophila willistoni GK17519 (Dwil\GK17519), mRNA K17696 EMC DNA-binding protein inhibitor ID, other http://www.genome.jp/dbget-bin/www_bget?ko:K17696 P18491 259 2.9e-21 Protein extra-macrochaetae OS=Drosophila melanogaster GN=emc PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.34361 BP_3 51.67 0.65 4103 91085815 XP_974770.1 991 3.3e-104 PREDICTED: maternal protein exuperantia-1 [Tribolium castaneum]>gi|270011046|gb|EFA07494.1| exuperantia [Tribolium castaneum] -- -- -- -- -- K18745 EXU maternal protein exuperantia http://www.genome.jp/dbget-bin/www_bget?ko:K18745 P28750 459 6.5e-44 Maternal protein exuperantia OS=Drosophila melanogaster GN=exu PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34363 BP_3 10.28 0.32 1827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34364 BP_3 184.58 5.30 1969 478258333 ENN78452.1 1152 3.3e-123 hypothetical protein YQE_05090, partial [Dendroctonus ponderosae]>gi|546677055|gb|ERL87964.1| hypothetical protein D910_05352 [Dendroctonus ponderosae] 197259972 EU921225.1 117 8.08585e-52 Thermonectus marmoratus putative long wavelength opsin mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q17292 1006 1.2e-107 Rhodopsin OS=Camponotus atriceps PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.34365 BP_3 650.36 1.61 19750 646716100 KDR19487.1 3053 0.0e+00 E3 ubiquitin-protein ligase MARCH6 [Zootermopsis nevadensis] 847042359 XM_012951711.1 93 1.80766e-37 PREDICTED: Jaculus jaculus membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (March6), mRNA K10661 MARCH6, DOA10 E3 ubiquitin-protein ligase MARCH6 http://www.genome.jp/dbget-bin/www_bget?ko:K10661 O60337 1868 1.3e-206 E3 ubiquitin-protein ligase MARCH6 OS=Homo sapiens GN=MARCH6 PE=1 SV=2 PF00400//PF12906//PF03165//PF13639//PF00004 WD domain, G-beta repeat//RING-variant domain//MH1 domain//Ring finger domain//ATPase family associated with various cellular activities (AAA) GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0008270//GO:0005524 protein binding//zinc ion binding//ATP binding GO:0005622 intracellular KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.34366 BP_3 192.66 0.48 19720 752870810 XP_011252574.1 2792 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MARCH6 [Camponotus floridanus] 847042359 XM_012951711.1 93 1.80491e-37 PREDICTED: Jaculus jaculus membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (March6), mRNA K18758 DIS3L2 DIS3-like exonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18758 Q8CI75 1227 2.8e-132 DIS3-like exonuclease 2 OS=Mus musculus GN=Dis3l2 PE=1 SV=1 PF13639//PF00004//PF00400//PF03165//PF12906 Ring finger domain//ATPase family associated with various cellular activities (AAA)//WD domain, G-beta repeat//MH1 domain//RING-variant domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0008270//GO:0005515 ATP binding//zinc ion binding//protein binding GO:0005622 intracellular KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-8309.34367 BP_3 1441.02 6.75 10587 91084143 XP_970053.1 9179 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X2 [Tribolium castaneum]>gi|270006644|gb|EFA03092.1| hypothetical protein TcasGA2_TC013000 [Tribolium castaneum] 642925099 XM_964960.2 1389 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9LV03 5399 0.0e+00 Glutamate synthase 1 [NADH], chloroplastic OS=Arabidopsis thaliana GN=GLT1 PE=2 SV=2 PF00833//PF07992//PF01494//PF00287//PF00869//PF01134//PF05834//PF13241//PF01593//PF12831//PF00743//PF04898//PF01070//PF00070//PF01493//PF01210//PF01266//PF04183//PF01645 Ribosomal S17//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Sodium / potassium ATPase beta chain//Flavivirus glycoprotein, central and dimerisation domains//Glucose inhibited division protein A//Lycopene cyclase protein//Putative NAD(P)-binding//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Flavin-binding monooxygenase-like//Glutamate synthase central domain//FMN-dependent dehydrogenase//Pyridine nucleotide-disulphide oxidoreductase//GXGXG motif//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//FAD dependent oxidoreductase//IucA / IucC family//Conserved region in glutamate synthase GO:0042254//GO:0055114//GO:0006779//GO:0006118//GO:0006814//GO:0008152//GO:0019354//GO:0046168//GO:0019290//GO:0016117//GO:0006537//GO:0006826//GO:0008033//GO:0006813//GO:0006412//GO:0006807 ribosome biogenesis//oxidation-reduction process//porphyrin-containing compound biosynthetic process//obsolete electron transport//sodium ion transport//metabolic process//siroheme biosynthetic process//glycerol-3-phosphate catabolic process//siderophore biosynthetic process//carotenoid biosynthetic process//glutamate biosynthetic process//iron ion transport//tRNA processing//potassium ion transport//translation//nitrogen compound metabolic process GO:0016616//GO:0010181//GO:0005506//GO:0003735//GO:0046983//GO:0016491//GO:0043115//GO:0015930//GO:0071949//GO:0016638//GO:0015343//GO:0051536//GO:0051287//GO:0016705//GO:0004499//GO:0050661//GO:0016040//GO:0050660 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//FMN binding//iron ion binding//structural constituent of ribosome//protein dimerization activity//oxidoreductase activity//precorrin-2 dehydrogenase activity//glutamate synthase activity//FAD binding//oxidoreductase activity, acting on the CH-NH2 group of donors//siderophore transmembrane transporter activity//iron-sulfur cluster binding//NAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//N,N-dimethylaniline monooxygenase activity//NADP binding//glutamate synthase (NADH) activity//flavin adenine dinucleotide binding GO:0005890//GO:0005840//GO:0005622 sodium:potassium-exchanging ATPase complex//ribosome//intracellular KOG0399 Glutamate synthase Cluster-8309.34368 BP_3 2481.90 15.11 8211 642925096 XP_008194167.1 6812 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum]>gi|642925098|ref|XP_008194168.1| PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum] 642925095 XM_008195945.1 465 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X1, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q0JKD0 4214 0.0e+00 Glutamate synthase 1 [NADH], chloroplastic OS=Oryza sativa subsp. japonica GN=Os01g0681900 PE=2 SV=1 PF05834//PF13241//PF01134//PF00869//PF01494//PF00287//PF07992//PF01645//PF01266//PF01210//PF01493//PF00070//PF01070//PF04898//PF00743//PF12831//PF01593 Lycopene cyclase protein//Putative NAD(P)-binding//Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains//FAD binding domain//Sodium / potassium ATPase beta chain//Pyridine nucleotide-disulphide oxidoreductase//Conserved region in glutamate synthase//FAD dependent oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//GXGXG motif//Pyridine nucleotide-disulphide oxidoreductase//FMN-dependent dehydrogenase//Glutamate synthase central domain//Flavin-binding monooxygenase-like//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase GO:0006537//GO:0006814//GO:0055114//GO:0008033//GO:0006779//GO:0019354//GO:0008152//GO:0046168//GO:0006813//GO:0016117//GO:0006807 glutamate biosynthetic process//sodium ion transport//oxidation-reduction process//tRNA processing//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//metabolic process//glycerol-3-phosphate catabolic process//potassium ion transport//carotenoid biosynthetic process//nitrogen compound metabolic process GO:0071949//GO:0016616//GO:0016638//GO:0016705//GO:0050661//GO:0004499//GO:0043115//GO:0051287//GO:0046983//GO:0016491//GO:0050660//GO:0015930 FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the CH-NH2 group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//NADP binding//N,N-dimethylaniline monooxygenase activity//precorrin-2 dehydrogenase activity//NAD binding//protein dimerization activity//oxidoreductase activity//flavin adenine dinucleotide binding//glutamate synthase activity GO:0005890 sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.34369 BP_3 145.67 0.85 8555 642925096 XP_008194167.1 6812 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum]>gi|642925098|ref|XP_008194168.1| PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum] 642925099 XM_964960.2 404 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9C102 4214 0.0e+00 Putative glutamate synthase [NADPH] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=glt1 PE=2 SV=1 PF01645//PF01266//PF01210//PF01493//PF00070//PF01070//PF04898//PF00743//PF01593//PF12831//PF13241//PF05834//PF01134//PF00869//PF01494//PF00287//PF07992 Conserved region in glutamate synthase//FAD dependent oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//GXGXG motif//Pyridine nucleotide-disulphide oxidoreductase//FMN-dependent dehydrogenase//Glutamate synthase central domain//Flavin-binding monooxygenase-like//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Putative NAD(P)-binding//Lycopene cyclase protein//Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains//FAD binding domain//Sodium / potassium ATPase beta chain//Pyridine nucleotide-disulphide oxidoreductase GO:0006813//GO:0019354//GO:0008152//GO:0046168//GO:0006807//GO:0016117//GO:0006537//GO:0055114//GO:0006779//GO:0008033//GO:0006814 potassium ion transport//siroheme biosynthetic process//metabolic process//glycerol-3-phosphate catabolic process//nitrogen compound metabolic process//carotenoid biosynthetic process//glutamate biosynthetic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//tRNA processing//sodium ion transport GO:0051287//GO:0046983//GO:0016491//GO:0016705//GO:0050661//GO:0043115//GO:0004499//GO:0015930//GO:0050660//GO:0016616//GO:0071949//GO:0016638 NAD binding//protein dimerization activity//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//NADP binding//precorrin-2 dehydrogenase activity//N,N-dimethylaniline monooxygenase activity//glutamate synthase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//FAD binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0005890 sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.34371 BP_3 263.87 1.45 9069 478260541 ENN80244.1 792 8.6e-81 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 1.80618e-29 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q9TSM6 517 2.7e-50 Protein tyrosine phosphatase type IVA 1 OS=Macaca fascicularis GN=PTP4A1 PE=1 SV=1 PF00782//PF01686//PF15750//PF00102 Dual specificity phosphatase, catalytic domain//Adenovirus penton base protein//Ubiquitin-binding zinc-finger//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0005198//GO:0008138//GO:0004725//GO:0043130 structural molecule activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//ubiquitin binding -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.34372 BP_3 7.04 0.44 1063 -- -- -- -- -- 642911796 XM_008202524.1 77 7.40796e-30 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34373 BP_3 27.80 0.41 3574 478257295 ENN77458.1 2459 1.7e-274 hypothetical protein YQE_06282, partial [Dendroctonus ponderosae] 572316028 XM_006623585.1 146 1.11913e-67 PREDICTED: Apis dorsata uncharacterized LOC102670726 (LOC102670726), transcript variant X2, mRNA -- -- -- -- P48053 735 5.6e-76 Uncharacterized protein C05D11.1 OS=Caenorhabditis elegans GN=C05D11.1 PE=4 SV=2 PF04987//PF08367 Phosphatidylinositolglycan class N (PIG-N)//Peptidase M16C associated GO:0006508//GO:0006506 proteolysis//GPI anchor biosynthetic process GO:0016740 transferase activity GO:0005789 endoplasmic reticulum membrane KOG2019 Metalloendoprotease HMP1 (insulinase superfamily) Cluster-8309.34374 BP_3 224.23 1.08 10292 546685894 ERL95319.1 1919 2.0e-211 hypothetical protein D910_12585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MSS1 515 5.3e-50 Protein lava lamp OS=Drosophila melanogaster GN=lva PE=1 SV=2 PF06463//PF10186 Molybdenum Cofactor Synthesis C//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006777//GO:0010508 Mo-molybdopterin cofactor biosynthetic process//positive regulation of autophagy GO:0051539 4 iron, 4 sulfur cluster binding GO:0019008 molybdopterin synthase complex KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.34376 BP_3 17.87 0.34 2812 91084625 XP_974579.1 1191 1.4e-127 PREDICTED: cullin-2 [Tribolium castaneum]>gi|270008911|gb|EFA05359.1| hypothetical protein TcasGA2_TC015524 [Tribolium castaneum] -- -- -- -- -- K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 638 7.9e-65 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2284 E3 ubiquitin ligase, Cullin 2 component Cluster-8309.34378 BP_3 389.67 13.79 1654 478252070 ENN72501.1 1998 2.2e-221 hypothetical protein YQE_10842, partial [Dendroctonus ponderosae] 768414731 XM_011549582.1 84 1.49663e-33 PREDICTED: Plutella xylostella uncharacterized LOC105380086 (LOC105380086), mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q9D4H8 1432 3.9e-157 Cullin-2 OS=Mus musculus GN=Cul2 PE=1 SV=2 PF08469//PF00888 Nucleoside triphosphatase I C-terminal//Cullin family GO:0006351//GO:0006511 transcription, DNA-templated//ubiquitin-dependent protein catabolic process GO:0031625//GO:0005524//GO:0017111 ubiquitin protein ligase binding//ATP binding//nucleoside-triphosphatase activity -- -- KOG2166 Cullins Cluster-8309.34379 BP_3 46.73 2.24 1298 642934319 XP_008198599.1 370 1.1e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34380 BP_3 1295.82 38.31 1922 332376935 AEE63607.1 1628 2.1e-178 unknown [Dendroctonus ponderosae]>gi|478259710|gb|ENN79554.1| hypothetical protein YQE_04016, partial [Dendroctonus ponderosae]>gi|546676265|gb|ERL87311.1| hypothetical protein D910_04706 [Dendroctonus ponderosae] 758206659 XM_011327360.1 36 8.40801e-07 Fusarium graminearum PH-1 aspartate aminotransferase partial mRNA K14454 GOT1 aspartate aminotransferase, cytoplasmic http://www.genome.jp/dbget-bin/www_bget?ko:K14454 P13221 1240 8.4e-135 Aspartate aminotransferase, cytoplasmic OS=Rattus norvegicus GN=Got1 PE=1 SV=3 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.34381 BP_3 1859.83 10.93 8496 91083999 XP_975264.1 1320 4.8e-142 PREDICTED: protein FAM13A [Tribolium castaneum]>gi|270006707|gb|EFA03155.1| hypothetical protein TcasGA2_TC013074 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYW0 267 2.5e-21 Protein FAM13A OS=Bos taurus GN=FAM13A PE=2 SV=1 PF11365 Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy -- -- GO:0005615 extracellular space -- -- Cluster-8309.34382 BP_3 13.00 2.62 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34383 BP_3 724.99 21.23 1938 646723788 KDR24282.1 1204 3.1e-129 Serine hydroxymethyltransferase, cytosolic [Zootermopsis nevadensis] 242024281 XM_002432512.1 73 2.29178e-27 Pediculus humanus corporis serine hydroxymethyltransferase, cytosolic, putative, mRNA K00600 glyA, SHMT glycine hydroxymethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00600 P34896 1024 9.4e-110 Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens GN=SHMT1 PE=1 SV=1 PF00464 Serine hydroxymethyltransferase -- -- GO:0016740 transferase activity -- -- KOG2467 Glycine/serine hydroxymethyltransferase Cluster-8309.34384 BP_3 372.21 15.42 1455 642933530 XP_008197457.1 904 1.4e-94 PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933532|ref|XP_008197458.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933534|ref|XP_008197459.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum] 462283408 APGK01056946.1 55 1.73447e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 4.2e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF09726//PF01080//PF07267//PF00076 Transmembrane protein//Presenilin//Nucleopolyhedrovirus capsid protein P87//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4733 FOG: RRM domain Cluster-8309.34386 BP_3 357.00 24.82 985 91091618 XP_969683.1 307 1.6e-25 PREDICTED: receptor-binding cancer antigen expressed on SiSo cells [Tribolium castaneum]>gi|270000900|gb|EEZ97347.1| hypothetical protein TcasGA2_TC011163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34387 BP_3 153.00 8.62 1147 270008456 EFA04904.1 572 3.5e-56 hypothetical protein TcasGA2_TC014968 [Tribolium castaneum] -- -- -- -- -- K13206 CCDC55 coiled-coil domain-containing protein 55 http://www.genome.jp/dbget-bin/www_bget?ko:K13206 Q568R1 273 6.8e-23 Nuclear speckle splicing regulatory protein 1 OS=Danio rerio GN=nsrp1 PE=1 SV=2 PF10717//PF02950 Occlusion-derived virus envelope protein ODV-E18//Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576//GO:0019031 extracellular region//viral envelope KOG2117 Uncharacterized conserved protein Cluster-8309.34388 BP_3 337.00 13.72 1476 859132827 AKO63324.1 1340 4.0e-145 geranylgeranyl pyrophosphate synthase [Leptinotarsa decemlineata] -- -- -- -- -- K00804 GGPS1 geranylgeranyl diphosphate synthase, type III http://www.genome.jp/dbget-bin/www_bget?ko:K00804 P56966 949 3.6e-101 Geranylgeranyl pyrophosphate synthase OS=Bos taurus GN=GGPS1 PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.34389 BP_3 940.27 16.28 3075 189237987 XP_001812710.1 3253 0.0e+00 PREDICTED: solute carrier family 12 member 9 [Tribolium castaneum] 632984903 XM_007911190.1 52 1.72649e-15 PREDICTED: Callorhinchus milii solute carrier family 12, member 9 (slc12a9), mRNA K14429 SLC12A9, CCC6 solute carrier family 12 (potassium/chloride transporters), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14429 A2BFP5 1750 9.8e-194 Solute carrier family 12 member 9 OS=Danio rerio GN=slc12a9 PE=3 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006810//GO:0006811//GO:0055085 transport//ion transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG1288 Amino acid transporters Cluster-8309.3439 BP_3 6.00 0.45 931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34391 BP_3 177.98 1.49 6063 91086459 XP_969641.1 1106 2.2e-117 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Tribolium castaneum] -- -- -- -- -- K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 P57093 721 4.0e-74 Phytanoyl-CoA dioxygenase, peroxisomal OS=Rattus norvegicus GN=Phyh PE=1 SV=2 PF12326 N-glycosylation protein GO:0034599 cellular response to oxidative stress -- -- GO:0005789 endoplasmic reticulum membrane KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.34395 BP_3 354.87 1.64 10721 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.34396 BP_3 23.00 0.31 3862 189236750 XP_975130.2 1692 1.6e-185 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 491 1.2e-47 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.34399 BP_3 2787.20 48.46 3064 270002486 EEZ98933.1 3164 0.0e+00 hypothetical protein TcasGA2_TC004554 [Tribolium castaneum] 749758627 XM_011142875.1 143 4.45624e-66 PREDICTED: Harpegnathos saltator furin-like protease 2 (LOC105184226), transcript variant X4, mRNA -- -- -- -- P30432 1916 5.5e-213 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00757//PF01483 Furin-like cysteine rich region//Proprotein convertase P-domain GO:0006508//GO:0007169//GO:0006468 proteolysis//transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0004714//GO:0004252 ATP binding//transmembrane receptor protein tyrosine kinase activity//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.34400 BP_3 20.39 0.44 2519 270002486 EEZ98933.1 1570 1.5e-171 hypothetical protein TcasGA2_TC004554 [Tribolium castaneum] 642912184 XM_964214.2 116 3.73523e-51 PREDICTED: Tribolium castaneum furin-like protease 2 (LOC657778), mRNA -- -- -- -- P30432 795 4.4e-83 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00757 Furin-like cysteine rich region GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0004714 ATP binding//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane -- -- Cluster-8309.34401 BP_3 699.00 8.21 4397 642921623 XP_008192451.1 1982 4.3e-219 PREDICTED: WD repeat-containing protein 6 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NNW5 648 8.5e-66 WD repeat-containing protein 6 OS=Homo sapiens GN=WDR6 PE=1 SV=1 PF00400//PF02932//PF07569 WD domain, G-beta repeat//Neurotransmitter-gated ion-channel transmembrane region//TUP1-like enhancer of split GO:0006811//GO:0006355 ion transport//regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0016020 nucleus//membrane KOG3113 Uncharacterized conserved protein Cluster-8309.34403 BP_3 954.29 6.59 7273 270003541 EEZ99988.1 3167 0.0e+00 hypothetical protein TcasGA2_TC002791 [Tribolium castaneum] 805798528 XM_012288489.1 131 4.98813e-59 PREDICTED: Megachile rotundata calponin homology domain-containing protein DDB_G0272472 (LOC100882081), transcript variant X2, mRNA K11478 JARID2, JMJ protein Jumonji http://www.genome.jp/dbget-bin/www_bget?ko:K11478 Q5F363 922 2.4e-97 Protein Jumonji OS=Gallus gallus GN=JARID2 PE=2 SV=1 PF02861//PF01388 Clp amino terminal domain, pathogenicity island component//ARID/BRIGHT DNA binding domain GO:0019538 protein metabolic process GO:0003677 DNA binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.34405 BP_3 2198.39 8.59 12629 270001906 EEZ98353.1 491 9.5e-46 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03131//PF04384//PF00170//PF07716//PF10541 bZIP Maf transcription factor//Iron-sulphur cluster assembly//bZIP transcription factor//Basic region leucine zipper//Nuclear envelope localisation domain GO:0006355//GO:0016226 regulation of transcription, DNA-templated//iron-sulfur cluster assembly GO:0043565//GO:0003700//GO:0003677 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005634//GO:0016021//GO:0005667 nucleus//integral component of membrane//transcription factor complex -- -- Cluster-8309.34407 BP_3 206.41 8.06 1526 646710939 KDR16317.1 278 5.8e-22 Eukaryotic translation initiation factor 3 subunit G [Zootermopsis nevadensis] -- -- -- -- -- K03248 EIF3G translation initiation factor 3 subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K03248 Q9VDM6 248 7.1e-20 Eukaryotic translation initiation factor 3 subunit G-2 OS=Drosophila melanogaster GN=eIF3-S4-2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.34408 BP_3 2184.75 98.21 1364 91080821 XP_966682.1 378 1.3e-33 PREDICTED: uncharacterized protein LOC658984 [Tribolium castaneum]>gi|270005906|gb|EFA02354.1| hypothetical protein TcasGA2_TC008024 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EF78 144 7.3e-08 Icarapin OS=Apis mellifera carnica PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34409 BP_3 7.00 2.46 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34410 BP_3 383.02 2.93 6594 642911773 XP_008200735.1 2345 5.2e-261 PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911775|ref|XP_008200736.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911777|ref|XP_008200737.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911779|ref|XP_008200738.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|270014735|gb|EFA11183.1| hypothetical protein TcasGA2_TC004791 [Tribolium castaneum] 397560823 JX204291.1 38 2.25715e-07 Sogatella furcifera membrane-bound trehalase mRNA, complete cds K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 A8J4S9 1814 8.0e-201 Trehalase OS=Apis mellifera PE=1 SV=1 PF01204 Trehalase GO:0005991//GO:0005982//GO:0005985 trehalose metabolic process//starch metabolic process//sucrose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.34411 BP_3 1947.05 31.95 3229 546676114 ERL87181.1 3057 0.0e+00 hypothetical protein D910_04581 [Dendroctonus ponderosae] 642913385 XM_964220.3 357 0 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q9H8M5 1371 9.1e-150 Metal transporter CNNM2 OS=Homo sapiens GN=CNNM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.34412 BP_3 82.46 1.22 3541 546676114 ERL87181.1 2895 0.0e+00 hypothetical protein D910_04581 [Dendroctonus ponderosae] 642913385 XM_964220.3 344 9.48891e-178 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q9H8M5 1369 1.7e-149 Metal transporter CNNM2 OS=Homo sapiens GN=CNNM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.34413 BP_3 955.33 24.33 2184 478250402 ENN70897.1 2544 1.4e-284 hypothetical protein YQE_12302, partial [Dendroctonus ponderosae] 751219340 XM_011164448.1 192 1.82489e-93 PREDICTED: Solenopsis invicta calpain-A-like (LOC105197860), transcript variant X10, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 2023 1.5e-225 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.34414 BP_3 373.98 8.43 2429 642923254 XP_008193679.1 700 1.1e-70 PREDICTED: DNA repair protein XRCC3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q08DH8 411 1.4e-38 DNA repair protein XRCC3 OS=Bos taurus GN=XRCC3 PE=2 SV=1 PF03796//PF00154 DnaB-like helicase C terminal domain//recA bacterial DNA recombination protein GO:0009432//GO:0006260//GO:0006281 SOS response//DNA replication//DNA repair GO:0003697//GO:0003678//GO:0005524 single-stranded DNA binding//DNA helicase activity//ATP binding GO:0005657 replication fork KOG1564 DNA repair protein RHP57 Cluster-8309.34416 BP_3 6676.01 46.29 7243 642934807 XP_008197818.1 2312 3.8e-257 PREDICTED: ninein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2I6 514 4.8e-50 Ninein-like protein OS=Homo sapiens GN=NINL PE=1 SV=2 PF00170//PF04977//PF13405//PF13499//PF15070//PF04479//PF01176//PF10473//PF05837 bZIP transcription factor//Septum formation initiator//EF-hand domain//EF-hand domain pair//Putative golgin subfamily A member 2-like protein 5//RTA1 like protein//Translation initiation factor 1A / IF-1//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centromere protein H (CENP-H) GO:0051382//GO:0007049//GO:0006355//GO:0006446//GO:0006950//GO:0006413 kinetochore assembly//cell cycle//regulation of transcription, DNA-templated//regulation of translational initiation//response to stress//translational initiation GO:0008134//GO:0045502//GO:0003743//GO:0003700//GO:0043565//GO:0003723//GO:0005509//GO:0042803 transcription factor binding//dynein binding//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//RNA binding//calcium ion binding//protein homodimerization activity GO:0005794//GO:0016021//GO:0005840//GO:0005667//GO:0030286//GO:0000776 Golgi apparatus//integral component of membrane//ribosome//transcription factor complex//dynein complex//kinetochore -- -- Cluster-8309.34417 BP_3 3065.94 61.88 2680 642934807 XP_008197818.1 1734 1.5e-190 PREDICTED: ninein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11929 237 2.4e-18 Blastoderm-specific protein 25D OS=Drosophila melanogaster GN=Bsg25D PE=1 SV=2 PF00170//PF06005 bZIP transcription factor//Protein of unknown function (DUF904) GO:0043093//GO:0000917//GO:0006355 FtsZ-dependent cytokinesis//barrier septum assembly//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.34418 BP_3 5.78 0.35 1093 642925687 XP_008194670.1 147 6.4e-07 PREDICTED: cytochrome b561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34419 BP_3 1025.65 8.25 6283 189241799 XP_970228.2 3095 0.0e+00 PREDICTED: inverted formin-2 [Tribolium castaneum]>gi|270001160|gb|EEZ97607.1| hypothetical protein TcasGA2_TC011477 [Tribolium castaneum] 642925592 XM_008196391.1 434 0 PREDICTED: Tribolium castaneum uncharacterized LOC658801 (LOC658801), mRNA -- -- -- -- Q9C0D6 714 2.7e-73 FH2 domain-containing protein 1 OS=Homo sapiens GN=FHDC1 PE=1 SV=2 PF06367//PF06371 Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0030036//GO:0016043 actin cytoskeleton organization//cellular component organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.34420 BP_3 863.53 33.29 1542 91086669 XP_968223.1 832 3.4e-86 PREDICTED: proteasomal ubiquitin receptor ADRM1 [Tribolium castaneum]>gi|270010393|gb|EFA06841.1| hypothetical protein TcasGA2_TC009784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NZ09 579 3.0e-58 Proteasomal ubiquitin receptor ADRM1 OS=Danio rerio GN=adrm1b PE=1 SV=1 PF04683 Proteasome complex subunit Rpn13 ubiquitin receptor -- -- -- -- GO:0005634//GO:0005737 nucleus//cytoplasm KOG3037 Cell membrane glycoprotein Cluster-8309.34423 BP_3 636.17 7.65 4302 642912316 XP_969236.2 2540 8.3e-284 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BZW8 1281 3.3e-139 NHL repeat-containing protein 2 OS=Mus musculus GN=Nhlrc2 PE=2 SV=1 PF01731//PF00085//PF01436 Arylesterase//Thioredoxin//NHL repeat GO:0045454 cell redox homeostasis GO:0004064//GO:0005515 arylesterase activity//protein binding -- -- -- -- Cluster-8309.34427 BP_3 2304.05 60.64 2123 478250669 ENN71161.1 1170 3.0e-125 hypothetical protein YQE_12091, partial [Dendroctonus ponderosae]>gi|546677253|gb|ERL88122.1| hypothetical protein D910_05510 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI23 736 2.6e-76 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34429 BP_3 11.00 1.38 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34431 BP_3 108.02 4.09 1565 91094739 XP_971002.1 702 4.0e-71 PREDICTED: uncharacterized protein LOC659618 [Tribolium castaneum]>gi|270010786|gb|EFA07234.1| hypothetical protein TcasGA2_TC010591 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BN57 213 8.4e-16 Protein C3orf33 homolog OS=Mus musculus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34435 BP_3 426.53 2.90 7386 642930106 XP_008196254.1 2024 9.7e-224 PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum]>gi|642930108|ref|XP_008196255.1| PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum] 686207191 AP014521.1 40 1.95564e-08 Candidatus Tachikawaea gelatinosa DNA, complete genome K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q96HY7 1540 5.3e-169 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Homo sapiens GN=DHTKD1 PE=1 SV=2 PF09412//PF00676 Endoribonuclease XendoU//Dehydrogenase E1 component GO:0008152 metabolic process GO:0016788//GO:0016624 hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.34436 BP_3 11.99 1.42 699 264667337 ACY71254.1 443 1.9e-41 ribosomal protein L11 [Chrysomela tremula] 769837621 XM_011631699.1 104 4.68692e-45 PREDICTED: Pogonomyrmex barbatus 60S ribosomal protein L11-like (LOC105422357), mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 P46222 440 1.8e-42 60S ribosomal protein L11 OS=Drosophila melanogaster GN=RpL11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-8309.34439 BP_3 85.28 0.65 6645 91092436 XP_968632.1 3814 0.0e+00 PREDICTED: laminin subunit gamma-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 3105 0.0e+00 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 PF02346//PF01466//PF06008//PF04632 Chordopoxvirus multifunctional envelope protein A27//Skp1 family, dimerisation domain//Laminin Domain I//Fusaric acid resistance protein family GO:0019064//GO:0006810//GO:0007165//GO:0030334//GO:0045995//GO:0006511//GO:0030155 fusion of virus membrane with host plasma membrane//transport//signal transduction//regulation of cell migration//regulation of embryonic development//ubiquitin-dependent protein catabolic process//regulation of cell adhesion GO:0005102 receptor binding GO:0019031//GO:0005886 viral envelope//plasma membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.34440 BP_3 120.78 1.30 4764 646704092 KDR12447.1 965 3.9e-101 Autophagy-related protein 13-like protein [Zootermopsis nevadensis] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 Q9VHR6 650 5.4e-66 Autophagy-related protein 13 homolog OS=Drosophila melanogaster GN=Atg13 PE=1 SV=1 PF09452//PF06667 ESCRT-I subunit Mvb12//Phage shock protein B GO:0006355//GO:0009271//GO:0032509 regulation of transcription, DNA-templated//phage shock//endosome transport via multivesicular body sorting pathway GO:0043130 ubiquitin binding GO:0000813 ESCRT I complex KOG3874 Uncharacterized conserved protein Cluster-8309.34444 BP_3 195.14 5.81 1910 478255591 ENN75805.1 2200 9.8e-245 hypothetical protein YQE_07641, partial [Dendroctonus ponderosae]>gi|546682293|gb|ERL92251.1| hypothetical protein D910_09568 [Dendroctonus ponderosae] 704290140 XM_010177591.1 138 1.66125e-63 PREDICTED: Caprimulgus carolinensis SNW domain containing 1 (SNW1), partial mRNA K06063 SNW1, SKIIP, SKIP SNW domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06063 P39736 1642 2.0e-181 Puff-specific protein Bx42 OS=Drosophila melanogaster GN=Bx42 PE=1 SV=1 PF02841//PF02731 Guanylate-binding protein, C-terminal domain//SKIP/SNW domain GO:0000398 mRNA splicing, via spliceosome GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005681 spliceosomal complex KOG2441 mRNA splicing factor/probable chromatin binding snw family nuclear protein Cluster-8309.34447 BP_3 412.36 2.42 8508 642918656 XP_008191524.1 2229 1.9e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.2e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF00433//PF01799//PF07714//PF00069//PF00463//PF07535//PF06220 Protein kinase C terminal domain//[2Fe-2S] binding domain//Protein tyrosine kinase//Protein kinase domain//Isocitrate lyase family//DBF zinc finger//U1 zinc finger GO:0019752//GO:0016310//GO:0009069//GO:0006468//GO:0006097//GO:0055114 carboxylic acid metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//glyoxylate cycle//oxidation-reduction process GO:0005524//GO:0016491//GO:0004451//GO:0005543//GO:0003676//GO:0008270//GO:0004672//GO:0046872//GO:0004674 ATP binding//oxidoreductase activity//isocitrate lyase activity//phospholipid binding//nucleic acid binding//zinc ion binding//protein kinase activity//metal ion binding//protein serine/threonine kinase activity -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.34448 BP_3 35.38 0.34 5293 642934019 XP_008197606.1 1061 3.2e-112 PREDICTED: PCTP-like protein isoform X1 [Tribolium castaneum] 642934018 XM_008199384.1 192 4.46273e-93 PREDICTED: Tribolium castaneum phosphatidylcholine transfer protein (LOC662808), transcript variant X1, mRNA -- -- -- -- Q9JMD3 495 5.7e-48 PCTP-like protein OS=Mus musculus GN=Stard10 PE=1 SV=1 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.34449 BP_3 1437.66 21.86 3461 642914288 XP_008201623.1 1679 4.6e-184 PREDICTED: ubiquitin-conjugating enzyme E2 Q2 [Tribolium castaneum] -- -- -- -- -- K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q7TSS2 992 8.7e-106 Ubiquitin-conjugating enzyme E2 Q1 OS=Mus musculus GN=Ube2q1 PE=1 SV=2 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.34450 BP_3 149.45 4.06 2067 642913818 XP_008201172.1 643 3.7e-64 PREDICTED: myosin light chain alkali isoform X1 [Tribolium castaneum] 642913817 XM_008202950.1 253 2.12427e-127 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 449 4.8e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13499//PF13405//PF00036 EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.34451 BP_3 107.32 4.50 1442 642929884 XP_008196012.1 683 5.9e-69 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 214 5.9e-16 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.34452 BP_3 401.75 15.99 1503 91083361 XP_975131.1 976 6.6e-103 PREDICTED: protein slowmo [Tribolium castaneum]>gi|270007772|gb|EFA04220.1| hypothetical protein TcasGA2_TC014470 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3U9 785 3.8e-82 Protein slowmo OS=Drosophila melanogaster GN=slmo PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3336 Predicted member of the intramitochondrial sorting protein family Cluster-8309.34453 BP_3 920.44 14.07 3445 642914288 XP_008201623.1 1693 1.1e-185 PREDICTED: ubiquitin-conjugating enzyme E2 Q2 [Tribolium castaneum] -- -- -- -- -- K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q7TSS2 988 2.5e-105 Ubiquitin-conjugating enzyme E2 Q1 OS=Mus musculus GN=Ube2q1 PE=1 SV=2 PF07973//PF05773 Threonyl and Alanyl tRNA synthetase second additional domain//RWD domain GO:0043039 tRNA aminoacylation GO:0005524//GO:0016876//GO:0005515 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//protein binding -- -- KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.34454 BP_3 48.28 1.10 2403 642914288 XP_008201623.1 387 2.1e-34 PREDICTED: ubiquitin-conjugating enzyme E2 Q2 [Tribolium castaneum] -- -- -- -- -- K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q7Z7E8 314 2.5e-27 Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens GN=UBE2Q1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.34456 BP_3 665.15 48.19 957 91076150 XP_970566.1 886 1.1e-92 PREDICTED: transmembrane protein 205 [Tribolium castaneum]>gi|270014570|gb|EFA11018.1| hypothetical protein TcasGA2_TC004605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GPW4 198 2.8e-14 Transmembrane protein 205 OS=Xenopus laevis GN=tmem205 PE=2 SV=1 PF05374 Mu-Conotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG2886 Uncharacterized conserved protein Cluster-8309.34458 BP_3 520.62 10.23 2745 861649070 KMQ96644.1 2150 8.8e-239 tyrosine-protein phosphatase non-receptor type 4 [Lasius niger] 817186761 XM_012432473.1 150 5.12086e-70 PREDICTED: Orussus abietinus tyrosine-protein phosphatase non-receptor type 4 (LOC105703795), transcript variant X5, mRNA K18037 PTPN4, MEG tyrosine-protein phosphatase non-receptor type 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18037 Q9WU22 1000 8.1e-107 Tyrosine-protein phosphatase non-receptor type 4 OS=Mus musculus GN=Ptpn4 PE=1 SV=2 PF00595//PF00782//PF13180//PF00102 PDZ domain (Also known as DHR or GLGF)//Dual specificity phosphatase, catalytic domain//PDZ domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding -- -- KOG0792 Protein tyrosine phosphatase PTPMEG, contains FERM domain Cluster-8309.34459 BP_3 1843.86 94.12 1236 642926253 XP_008194845.1 1301 1.1e-140 PREDICTED: prohibitin-2 isoform X2 [Tribolium castaneum] 195487314 XM_002091822.1 126 4.98586e-57 Drosophila yakuba GE12002 (Dyak\GE12002), partial mRNA K17081 PHB2 prohibitin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17081 Q99623 1045 2.2e-112 Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3090 Prohibitin-like protein Cluster-8309.34461 BP_3 7582.79 248.25 1764 478256938 ENN77107.1 746 3.6e-76 hypothetical protein YQE_06442, partial [Dendroctonus ponderosae] 642915784 XM_963085.2 242 2.35476e-121 PREDICTED: Tribolium castaneum cofilin/actin-depolymerizing factor homolog (LOC656560), mRNA K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 678 1.1e-69 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF07361//PF00241 Cytochrome b562//Cofilin/tropomyosin-type actin-binding protein GO:0022900//GO:0006118 electron transport chain//obsolete electron transport GO:0003779//GO:0005506//GO:0020037//GO:0009055 actin binding//iron ion binding//heme binding//electron carrier activity GO:0042597//GO:0005622 periplasmic space//intracellular KOG1735 Actin depolymerizing factor Cluster-8309.34463 BP_3 292.88 7.88 2084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895 Signal transducing histidine kinase, homodimeric domain GO:0000160//GO:0006935//GO:0016310 phosphorelay signal transduction system//chemotaxis//phosphorylation GO:0000155//GO:0004673 phosphorelay sensor kinase activity//protein histidine kinase activity GO:0005737//GO:0009365 cytoplasm//protein histidine kinase complex -- -- Cluster-8309.34464 BP_3 421.63 11.17 2111 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895 Signal transducing histidine kinase, homodimeric domain GO:0006935//GO:0000160//GO:0016310 chemotaxis//phosphorelay signal transduction system//phosphorylation GO:0004673//GO:0000155 protein histidine kinase activity//phosphorelay sensor kinase activity GO:0009365//GO:0005737 protein histidine kinase complex//cytoplasm -- -- Cluster-8309.34469 BP_3 42.14 0.38 5656 642927459 XP_968905.2 1211 1.4e-129 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q9EQZ5 716 1.4e-73 Prostaglandin reductase 1 OS=Cavia porcellus GN=Ptgr1 PE=1 SV=1 PF00787//PF01118//PF00107//PF12763 PX domain//Semialdehyde dehydrogenase, NAD binding domain//Zinc-binding dehydrogenase//Cytoskeletal-regulatory complex EF hand GO:0055114 oxidation-reduction process GO:0051287//GO:0016620//GO:0035091//GO:0005515 NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//phosphatidylinositol binding//protein binding -- -- KOG1196 Predicted NAD-dependent oxidoreductase Cluster-8309.34470 BP_3 4933.82 54.24 4676 189235452 XP_971512.2 641 1.4e-63 PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum]>gi|642916717|ref|XP_008192324.1| PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum] -- -- -- -- -- K16759 CCDC102A coiled-coil domain-containing protein 102A http://www.genome.jp/dbget-bin/www_bget?ko:K16759 Q96A19 379 1.4e-34 Coiled-coil domain-containing protein 102A OS=Homo sapiens GN=CCDC102A PE=1 SV=2 PF04136//PF00015//PF07464//PF10473//PF02050//PF07544//PF17082//PF04048//PF04111//PF01576//PF09728//PF07926//PF03938//PF11403//PF02601//PF03233//PF00038//PF07058//PF04632//PF08287//PF07851//PF01920//PF13851//PF10392//PF08395//PF06160//PF05557//PF08397//PF11365//PF00769//PF11802//PF03836//PF04799//PF07989//PF05837//PF08702//PF04513//PF06008//PF06009//PF04977//PF16331//PF06810//PF10174//PF04508 Sec34-like family//Methyl-accepting chemotaxis protein (MCP) signalling domain//Apolipophorin-III precursor (apoLp-III)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Flagellar FliJ protein//RNA polymerase II transcription mediator complex subunit 9//Spindle Pole Component 29//Sec8 exocyst complex component specific domain//Autophagy protein Apg6//Myosin tail//Myosin-like coiled-coil protein//TPR/MLP1/MLP2-like protein//Outer membrane protein (OmpH-like)//Yeast metallothionein//Exonuclease VII, large subunit//Aphid transmission protein//Intermediate filament protein//Microtubule-associated protein 70//Fusaric acid resistance protein family//Spc19//TMPIT-like protein//Prefoldin subunit//Growth-arrest specific micro-tubule binding//Golgi transport complex subunit 5//7tm Chemosensory receptor//Septation ring formation regulator, EzrA//Mitotic checkpoint protein//IRSp53/MIM homology domain//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Centromere-associated protein K//RasGAP C-terminus//fzo-like conserved region//Centrosomin N-terminal motif 1//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Laminin Domain I//Laminin Domain II//Septum formation initiator//TolA binding protein trimerisation//Phage minor structural protein GP20//RIM-binding protein of the cytomatrix active zone//Viral A-type inclusion protein repeat GO:0030155//GO:0007155//GO:0007009//GO:0006308//GO:0006869//GO:0010273//GO:0030334//GO:0051258//GO:0071585//GO:0008053//GO:0006935//GO:0071973//GO:0006904//GO:0030474//GO:0000921//GO:0006606//GO:0045995//GO:0050909//GO:0007094//GO:0006457//GO:0007049//GO:0015031//GO:0007165//GO:0006914//GO:0006886//GO:0007010//GO:0070206//GO:0006810//GO:0030168//GO:0007264//GO:0016032//GO:0006891//GO:0048870//GO:0019089//GO:0008608//GO:0006357//GO:0010506//GO:0051382 regulation of cell adhesion//cell adhesion//plasma membrane organization//DNA catabolic process//lipid transport//detoxification of copper ion//regulation of cell migration//protein polymerization//detoxification of cadmium ion//mitochondrial fusion//chemotaxis//bacterial-type flagellum-dependent cell motility//vesicle docking involved in exocytosis//spindle pole body duplication//septin ring assembly//protein import into nucleus//regulation of embryonic development//sensory perception of taste//mitotic spindle assembly checkpoint//protein folding//cell cycle//protein transport//signal transduction//autophagy//intracellular protein transport//cytoskeleton organization//protein trimerization//transport//platelet activation//small GTPase mediated signal transduction//viral process//intra-Golgi vesicle-mediated transport//cell motility//transmission of virus//attachment of spindle microtubules to kinetochore//regulation of transcription from RNA polymerase II promoter//regulation of autophagy//kinetochore assembly GO:0004871//GO:0005507//GO:0008855//GO:0005096//GO:0005198//GO:0008092//GO:0008289//GO:0005200//GO:0008134//GO:0042803//GO:0008017//GO:0030674//GO:0003774//GO:0001104//GO:0019905//GO:0051082//GO:0005102//GO:0046870//GO:0003924//GO:0045502 signal transducer activity//copper ion binding//exodeoxyribonuclease VII activity//GTPase activator activity//structural molecule activity//cytoskeletal protein binding//lipid binding//structural constituent of cytoskeleton//transcription factor binding//protein homodimerization activity//microtubule binding//protein binding, bridging//motor activity//RNA polymerase II transcription cofactor activity//syntaxin binding//unfolded protein binding//receptor binding//cadmium ion binding//GTPase activity//dynein binding GO:0005576//GO:0000145//GO:0019031//GO:0005823//GO:0042729//GO:0005737//GO:0005876//GO:0005815//GO:0016021//GO:0016459//GO:0005940//GO:0016592//GO:0030286//GO:0009318//GO:0048786//GO:0005577//GO:0019898//GO:0005882//GO:0005741//GO:0017119//GO:0016020//GO:0005634//GO:0005856//GO:0005886//GO:0005801//GO:0031514//GO:0000776//GO:0005667//GO:0009288//GO:0005615//GO:0016272//GO:0019028//GO:0045298 extracellular region//exocyst//viral envelope//central plaque of spindle pole body//DASH complex//cytoplasm//spindle microtubule//microtubule organizing center//integral component of membrane//myosin complex//septin ring//mediator complex//dynein complex//exodeoxyribonuclease VII complex//presynaptic active zone//fibrinogen complex//extrinsic component of membrane//intermediate filament//mitochondrial outer membrane//Golgi transport complex//membrane//nucleus//cytoskeleton//plasma membrane//cis-Golgi network//motile cilium//kinetochore//transcription factor complex//bacterial-type flagellum//extracellular space//prefoldin complex//viral capsid//tubulin complex -- -- Cluster-8309.34471 BP_3 178.77 1.37 6572 642936804 XP_008199623.1 5937 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 7.3e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF10473//PF06160//PF07926//PF08702//PF00910//PF00307//PF16326//PF04111//PF07728//PF01695//PF01832//PF16716//PF00004//PF13851 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//TPR/MLP1/MLP2-like protein//Fibrinogen alpha/beta chain family//RNA helicase//Calponin homology (CH) domain//ABC transporter C-terminal domain//Autophagy protein Apg6//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//Bone marrow stromal antigen 2//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding GO:0007165//GO:0006914//GO:0051258//GO:0006558//GO:0042207//GO:0006560//GO:0051607//GO:0006525//GO:0006568//GO:0006606//GO:0018874//GO:0000921//GO:0048870//GO:0030168 signal transduction//autophagy//protein polymerization//L-phenylalanine metabolic process//styrene catabolic process//proline metabolic process//defense response to virus//arginine metabolic process//tryptophan metabolic process//protein import into nucleus//benzoate metabolic process//septin ring assembly//cell motility//platelet activation GO:0003677//GO:0004040//GO:0003723//GO:0005515//GO:0042803//GO:0003724//GO:0005524//GO:0045502//GO:0008134//GO:0005102//GO:0016887//GO:0030674 DNA binding//amidase activity//RNA binding//protein binding//protein homodimerization activity//RNA helicase activity//ATP binding//dynein binding//transcription factor binding//receptor binding//ATPase activity//protein binding, bridging GO:0031514//GO:0016021//GO:0005940//GO:0005577//GO:0030286//GO:0005667 motile cilium//integral component of membrane//septin ring//fibrinogen complex//dynein complex//transcription factor complex -- -- Cluster-8309.34472 BP_3 212.99 36.88 570 91083531 XP_973193.1 501 3.0e-48 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q28960 221 3.6e-17 Carbonyl reductase [NADPH] 1 OS=Sus scrofa GN=CBR1 PE=1 SV=3 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.34476 BP_3 1354.27 18.04 3910 91084587 XP_974100.1 2514 7.8e-281 PREDICTED: zinc finger FYVE domain-containing protein 9 [Tribolium castaneum]>gi|270008651|gb|EFA05099.1| hypothetical protein TcasGA2_TC015198 [Tribolium castaneum] -- -- -- -- -- K04679 MADHIP, SARA MAD, mothers against decapentaplegic interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K04679 O95405 1383 4.5e-151 Zinc finger FYVE domain-containing protein 9 OS=Homo sapiens GN=ZFYVE9 PE=1 SV=2 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1841 Smad anchor for receptor activation Cluster-8309.34477 BP_3 613.64 4.52 6837 332376178 AEE63229.1 915 3.5e-95 unknown [Dendroctonus ponderosae] 642924593 XM_008196134.1 241 3.32878e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.3e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 PF06810 Phage minor structural protein GP20 -- -- GO:0005198 structural molecule activity -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.34479 BP_3 68.82 2.03 1924 642936774 XP_008198575.1 406 1.0e-36 PREDICTED: uncharacterized protein LOC661827 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.3448 BP_3 3.50 0.33 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34480 BP_3 5486.49 120.19 2492 731286412 XP_010611509.1 690 1.6e-69 PREDICTED: LOW QUALITY PROTEIN: histone H3.3 [Fukomys damarensis] 805824145 XM_003708049.2 153 9.98584e-72 PREDICTED: Megachile rotundata histone H3.3 (LOC100883938), mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P84246 676 2.7e-69 Histone H3.3 OS=Oryctolagus cuniculus GN=H3F3A PE=2 SV=2 PF15715//PF00125 PCNA-associated factor//Core histone H2A/H2B/H3/H4 GO:0051726//GO:0006974 regulation of cell cycle//cellular response to DNA damage stimulus GO:0003677 DNA binding -- -- KOG1745 Histones H3 and H4 Cluster-8309.34481 BP_3 233.13 3.82 3233 642933939 XP_008197575.1 2048 7.0e-227 PREDICTED: ADP-ribosylation factor-binding protein GGA3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12404 GGA ADP-ribosylation factor-binding protein GGA http://www.genome.jp/dbget-bin/www_bget?ko:K12404 Q8R0H9 662 1.5e-67 ADP-ribosylation factor-binding protein GGA1 OS=Mus musculus GN=Gga1 PE=1 SV=1 PF03127//PF00790//PF15009//PF02883 GAT domain//VHS domain//Transmembrane protein 173//Adaptin C-terminal domain GO:0016192//GO:0032481//GO:0006886//GO:0002218 vesicle-mediated transport//positive regulation of type I interferon production//intracellular protein transport//activation of innate immune response -- -- GO:0005622//GO:0030131 intracellular//clathrin adaptor complex KOG1086 Cytosolic sorting protein/ADP-ribosylation factor effector GGA Cluster-8309.34482 BP_3 36.66 0.49 3886 270015601 EFA12049.1 1924 2.0e-212 hypothetical protein TcasGA2_TC001466 [Tribolium castaneum] -- -- -- -- -- K17277 EPS8 epidermal growth factor receptor kinase substrate 8 http://www.genome.jp/dbget-bin/www_bget?ko:K17277 Q8TE68 506 2.2e-49 Epidermal growth factor receptor kinase substrate 8-like protein 1 OS=Homo sapiens GN=EPS8L1 PE=1 SV=3 PF08416//PF09286//PF14604//PF00018 Phosphotyrosine-binding domain//Pro-kumamolisin, activation domain//Variant SH3 domain//SH3 domain -- -- GO:0005515//GO:0008236 protein binding//serine-type peptidase activity -- -- KOG3557 Epidermal growth factor receptor kinase substrate Cluster-8309.34484 BP_3 1330.41 31.09 2354 642931172 XP_008196469.1 1319 1.7e-142 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34485 BP_3 820.00 61.16 938 91086729 XP_971227.1 469 2.5e-44 PREDICTED: uncharacterized protein LOC659867 [Tribolium castaneum]>gi|270009730|gb|EFA06178.1| hypothetical protein TcasGA2_TC009025 [Tribolium castaneum] -- -- -- -- -- K03956 NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K03956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34487 BP_3 490.42 10.01 2654 642928356 XP_008195548.1 1493 1.3e-162 PREDICTED: abhydrolase domain-containing protein 4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K13699 ABHD5, CGI-58 abhydrolase domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13699 Q5RBI4 855 5.1e-90 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 OS=Pongo abelii GN=ABHD5 PE=2 SV=1 PF01055//PF02230//PF00975//PF01764//PF16929//PF07819//PF07859//PF03403 Glycosyl hydrolases family 31//Phospholipase/Carboxylesterase//Thioesterase domain//Lipase (class 3)//Accessory Sec system GspB-transporter//PGAP1-like protein//alpha/beta hydrolase fold//Platelet-activating factor acetylhydrolase, isoform II GO:0016042//GO:0046486//GO:0009058//GO:0005975//GO:0015031//GO:0008152//GO:0006505//GO:0006629//GO:0006886 lipid catabolic process//glycerolipid metabolic process//biosynthetic process//carbohydrate metabolic process//protein transport//metabolic process//GPI anchor metabolic process//lipid metabolic process//intracellular protein transport GO:0016787//GO:0003847//GO:0004553//GO:0016788 hydrolase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.34488 BP_3 732.00 8.08 4657 -- -- -- -- -- 642927804 XM_966071.3 102 4.2104e-43 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (LOC659798), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34489 BP_3 80.10 0.65 6220 642935794 XP_008198177.1 369 6.6e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00864//PF00335 ATP P2X receptor//Tetraspanin family GO:0007165//GO:0006812//GO:0033198//GO:0098655 signal transduction//cation transport//response to ATP//cation transmembrane transport GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane -- -- Cluster-8309.34490 BP_3 10.10 0.85 863 546679897 ERL90285.1 401 1.8e-36 hypothetical protein D910_07637 [Dendroctonus ponderosae] 264667356 GU120414.1 95 5.88427e-40 Chrysomela tremulae ribosomal protein S27 (RpS27) mRNA, complete cds K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 Q6ZWU9 289 7.1e-25 40S ribosomal protein S27 OS=Mus musculus GN=Rps27 PE=1 SV=3 PF01667 Ribosomal protein S27 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1779 40s ribosomal protein S27 Cluster-8309.34491 BP_3 888.00 23.68 2099 189240498 XP_001810958.1 950 9.5e-100 PREDICTED: uncharacterized protein LOC657358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34493 BP_3 2638.00 35.65 3858 91082073 XP_966419.1 3806 0.0e+00 PREDICTED: 26S proteasome non-ATPase regulatory subunit 1 [Tribolium castaneum] 195341140 XM_002037134.1 390 0 Drosophila sechellia GM12772 (Dsec\GM12772), mRNA K03032 PSMD1, RPN2 26S proteasome regulatory subunit N2 http://www.genome.jp/dbget-bin/www_bget?ko:K03032 Q9V3P6 3237 0.0e+00 26S proteasome non-ATPase regulatory subunit 1 OS=Drosophila melanogaster GN=Rpn2 PE=1 SV=1 PF02985//PF05132 HEAT repeat//RNA polymerase III RPC4 GO:0006206//GO:0006351//GO:0006383//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005666//GO:0005730 DNA-directed RNA polymerase III complex//nucleolus KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1 Cluster-8309.34495 BP_3 28.75 1.49 1223 646718601 KDR21013.1 277 6.0e-22 hypothetical protein L798_04525 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6NZZ4 210 1.5e-15 Transmembrane protein 107 OS=Danio rerio GN=tmem107 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.345 BP_3 4.00 0.32 888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3450 BP_3 3.00 0.57 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34500 BP_3 402.00 13.63 1713 189233602 XP_001810921.1 1256 2.5e-135 PREDICTED: F-box only protein 28 [Tribolium castaneum] -- -- -- -- -- K10306 FBXO28 F-box protein 28 http://www.genome.jp/dbget-bin/www_bget?ko:K10306 Q2NL16 558 9.1e-56 F-box only protein 28 OS=Bos taurus GN=FBXO28 PE=2 SV=1 PF07851//PF00646//PF11744//PF12937//PF04108//PF10778//PF17060 TMPIT-like protein//F-box domain//Aluminium activated malate transporter//F-box-like//Autophagy protein Apg17//Halocarboxylic acid dehydrogenase DehI//Monopolar spindle protein 2 GO:0030474//GO:0006914//GO:0015743//GO:0071988 spindle pole body duplication//autophagy//malate transport//protein localization to spindle pole body GO:0005515//GO:0019120 protein binding//hydrolase activity, acting on acid halide bonds, in C-halide compounds GO:0016021 integral component of membrane -- -- Cluster-8309.34502 BP_3 188.13 2.34 4159 642918967 XP_008191677.1 4787 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918969|ref|XP_008191678.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918971|ref|XP_008191679.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918973|ref|XP_008191680.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918975|ref|XP_008191681.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.29498e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3178 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122//PF05109 E1-E2 ATPase//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058 viral life cycle GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.34503 BP_3 284.00 35.16 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34504 BP_3 313.10 8.13 2149 91080419 XP_968050.1 1723 2.2e-189 PREDICTED: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [Tribolium castaneum]>gi|270005750|gb|EFA02198.1| hypothetical protein TcasGA2_TC007854 [Tribolium castaneum] -- -- -- -- -- K01001 ALG7 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01001 Q9H3H5 1192 3.5e-129 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase OS=Homo sapiens GN=DPAGT1 PE=1 SV=2 PF00953 Glycosyl transferase family 4 GO:0009252//GO:0006629 peptidoglycan biosynthetic process//lipid metabolic process GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GO:0016021 integral component of membrane KOG2788 Glycosyltransferase Cluster-8309.34505 BP_3 687.00 40.47 1110 91080581 XP_973561.1 1144 1.6e-122 PREDICTED: splicing factor 3A subunit 2 [Tribolium castaneum]>gi|270005516|gb|EFA01964.1| hypothetical protein TcasGA2_TC007585 [Tribolium castaneum] 648215768 NM_001293501.1 234 4.10465e-117 Acyrthosiphon pisum splicing factor 3A subunit 2 (LOC100159176), mRNA >gnl|BL_ORD_ID|6893865 Acyrthosiphon pisum ACYPI000572 mRNA, clone: 636K7, complete cds, full-insert cDNA sequence based on the ESTs (5'-EST:FF319503, 3'-EST:FF320245) K12826 SF3A2, SAP62 splicing factor 3A subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12826 Q6AXT8 982 4.0e-105 Splicing factor 3A subunit 2 OS=Rattus norvegicus GN=Sf3a2 PE=2 SV=1 PF09732 Cactus-binding C-terminus of cactin protein -- -- GO:0005515//GO:0046872//GO:0008270//GO:0003676 protein binding//metal ion binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0227 Splicing factor 3a, subunit 2 Cluster-8309.34506 BP_3 746.88 44.21 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34507 BP_3 1372.14 13.09 5346 189239912 XP_971042.2 1378 5.7e-149 PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|642931218|ref|XP_008196488.1| PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|270012116|gb|EFA08564.1| hypothetical protein TcasGA2_TC006219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GLM5 222 2.6e-16 Desumoylating isopeptidase 1 OS=Xenopus laevis GN=desi1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.34508 BP_3 16.08 0.61 1570 332372618 AEE61451.1 836 1.2e-86 unknown [Dendroctonus ponderosae]>gi|478254395|gb|ENN74647.1| hypothetical protein YQE_08765, partial [Dendroctonus ponderosae]>gi|546682357|gb|ERL92305.1| hypothetical protein D910_09622 [Dendroctonus ponderosae] -- -- -- -- -- K15433 CGI99, CLE7, RLLM1 RLL motif containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15433 Q9Y224 417 1.9e-39 UPF0568 protein C14orf166 OS=Homo sapiens GN=C14orf166 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4380 Carnitine deficiency associated protein Cluster-8309.34509 BP_3 55.50 0.51 5564 642927190 XP_008195173.1 6794 0.0e+00 PREDICTED: DNA-directed RNA polymerase II subunit RPB1 [Tribolium castaneum]>gi|270010112|gb|EFA06560.1| hypothetical protein TcasGA2_TC009471 [Tribolium castaneum] 820864249 XM_012493280.1 1732 0 PREDICTED: Apis florea DNA-directed RNA polymerase II subunit RPB1-like (LOC100870960), mRNA K03006 RPB1, POLR2A DNA-directed RNA polymerase II subunit RPB1 http://www.genome.jp/dbget-bin/www_bget?ko:K03006 P04052 6343 0.0e+00 DNA-directed RNA polymerase II subunit RPB1 OS=Drosophila melanogaster GN=RpII215 PE=3 SV=4 PF04990//PF05000//PF04983//PF04998//PF01381//PF04997//PF00623//PF05001//PF04992 RNA polymerase Rpb1, domain 7//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 5//Helix-turn-helix//RNA polymerase Rpb1, domain 1//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1 C-terminal repeat//RNA polymerase Rpb1, domain 6 GO:0006144//GO:0006366//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription from RNA polymerase II promoter//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0043565 DNA-directed RNA polymerase activity//DNA binding//sequence-specific DNA binding GO:0005665//GO:0005730 DNA-directed RNA polymerase II, core complex//nucleolus KOG0260 RNA polymerase II, large subunit Cluster-8309.34510 BP_3 37040.85 1270.46 1697 662186144 XP_008480683.1 1100 3.1e-117 PREDICTED: tubulin beta-1 chain [Diaphorina citri] 164683615 EU373305.1 709 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q24560 1099 1.7e-118 Tubulin beta-1 chain OS=Drosophila melanogaster GN=betaTub56D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1375 Beta tubulin Cluster-8309.34511 BP_3 15.64 0.31 2739 332376166 AEE63223.1 796 8.9e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q86BN8 611 1.0e-61 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Drosophila melanogaster GN=Plip PE=2 SV=1 PF00782//PF07062//PF00102 Dual specificity phosphatase, catalytic domain//Clc-like//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity GO:0016021 integral component of membrane KOG1719 Dual specificity phosphatase Cluster-8309.34514 BP_3 288.67 9.09 1823 189239156 XP_971579.2 1213 2.6e-130 PREDICTED: 39S ribosomal protein L37, mitochondrial [Tribolium castaneum]>gi|270010833|gb|EFA07281.1| hypothetical protein TcasGA2_TC014515 [Tribolium castaneum] -- -- -- -- -- K17418 MRPL37 large subunit ribosomal protein L37 http://www.genome.jp/dbget-bin/www_bget?ko:K17418 Q9BZE1 239 9.4e-19 39S ribosomal protein L37, mitochondrial OS=Homo sapiens GN=MRPL37 PE=1 SV=2 PF07147 Mitochondrial 28S ribosomal protein S30 (PDCD9) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005739//GO:0043229//GO:0044444//GO:0005840 mitochondrion//intracellular organelle//cytoplasmic part//ribosome -- -- Cluster-8309.34515 BP_3 21.47 1.16 1183 189239156 XP_971579.2 1064 3.2e-113 PREDICTED: 39S ribosomal protein L37, mitochondrial [Tribolium castaneum]>gi|270010833|gb|EFA07281.1| hypothetical protein TcasGA2_TC014515 [Tribolium castaneum] -- -- -- -- -- K17418 MRPL37 large subunit ribosomal protein L37 http://www.genome.jp/dbget-bin/www_bget?ko:K17418 Q9BZE1 220 9.8e-17 39S ribosomal protein L37, mitochondrial OS=Homo sapiens GN=MRPL37 PE=1 SV=2 -- -- -- -- -- -- GO:0044444//GO:0043229 cytoplasmic part//intracellular organelle -- -- Cluster-8309.34516 BP_3 1208.86 14.32 4361 642936108 XP_974757.2 1282 6.3e-138 PREDICTED: fumarylacetoacetate hydrolase domain-containing protein 2A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96GK7 823 4.3e-86 Fumarylacetoacetate hydrolase domain-containing protein 2A OS=Homo sapiens GN=FAHD2A PE=1 SV=1 PF01632//PF01557 Ribosomal protein L35//Fumarylacetoacetate (FAA) hydrolase family GO:0042254//GO:0006412//GO:0008152 ribosome biogenesis//translation//metabolic process GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG1535 Predicted fumarylacetoacetate hydralase Cluster-8309.34518 BP_3 206.57 22.06 743 91091878 XP_969758.1 559 7.3e-55 PREDICTED: von Willebrand factor D and EGF domain-containing protein [Tribolium castaneum]>gi|270001301|gb|EEZ97748.1| nimrod B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2E2 169 5.0e-11 von Willebrand factor D and EGF domain-containing protein OS=Homo sapiens GN=VWDE PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34519 BP_3 263.00 9.24 1663 332376717 AEE63498.1 1208 9.1e-130 unknown [Dendroctonus ponderosae]>gi|478259809|gb|ENN79637.1| hypothetical protein YQE_03926, partial [Dendroctonus ponderosae]>gi|546676567|gb|ERL87551.1| hypothetical protein D910_04942 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5BLY5 636 7.9e-65 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.34520 BP_3 54.43 0.49 5646 827549501 XP_012546855.1 643 1.0e-63 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.6e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.34521 BP_3 29.35 0.51 3061 91081871 XP_968443.1 1594 2.9e-174 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q99LB7 1137 1.2e-122 Sarcosine dehydrogenase, mitochondrial OS=Mus musculus GN=Sardh PE=1 SV=1 PF11501//PF07992//PF01494//PF12831//PF01266//PF13241//PF02558//PF01134 Non structural protein Nsp1//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Putative NAD(P)-binding//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A GO:0006508//GO:0044710//GO:0019354//GO:0008033//GO:0006779//GO:0055114//GO:0015940 proteolysis//single-organism metabolic process//siroheme biosynthetic process//tRNA processing//porphyrin-containing compound biosynthetic process//oxidation-reduction process//pantothenate biosynthetic process GO:0016817//GO:0004197//GO:0050660//GO:0008677//GO:0016491//GO:0043115//GO:0008242//GO:0016788//GO:0003824//GO:0016740//GO:0071949 hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//oxidoreductase activity//precorrin-2 dehydrogenase activity//omega peptidase activity//hydrolase activity, acting on ester bonds//catalytic activity//transferase activity//FAD binding -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.34522 BP_3 182.25 3.18 3054 91081871 XP_968443.1 2434 1.1e-271 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q64380 1609 2.2e-177 Sarcosine dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Sardh PE=1 SV=2 PF01494//PF07992//PF11501//PF12831//PF01266//PF13241//PF02558//PF01134 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Non structural protein Nsp1//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Putative NAD(P)-binding//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A GO:0006508//GO:0019354//GO:0044710//GO:0055114//GO:0008033//GO:0006779//GO:0015940 proteolysis//siroheme biosynthetic process//single-organism metabolic process//oxidation-reduction process//tRNA processing//porphyrin-containing compound biosynthetic process//pantothenate biosynthetic process GO:0050660//GO:0008677//GO:0004197//GO:0016817//GO:0016788//GO:0003824//GO:0008242//GO:0043115//GO:0016491//GO:0071949//GO:0016740 flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//cysteine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//hydrolase activity, acting on ester bonds//catalytic activity//omega peptidase activity//precorrin-2 dehydrogenase activity//oxidoreductase activity//FAD binding//transferase activity -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.34526 BP_3 272.55 4.69 3092 642931035 XP_008196187.1 394 4.1e-35 PREDICTED: uncharacterized protein LOC103313793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09297//PF05497 NADH pyrophosphatase zinc ribbon domain//Destabilase GO:0005975 carbohydrate metabolic process GO:0016787//GO:0003796//GO:0046872 hydrolase activity//lysozyme activity//metal ion binding -- -- -- -- Cluster-8309.34527 BP_3 73.37 0.69 5387 189239886 XP_969203.2 1791 7.3e-197 PREDICTED: protein tweety [Tribolium castaneum] 642931168 XM_964110.3 243 2.0256e-121 PREDICTED: Tribolium castaneum protein tweety (LOC657663), mRNA -- -- -- -- Q9U6L4 1074 4.2e-115 Protein tweety OS=Drosophila melanogaster GN=tty PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.34528 BP_3 119.37 11.55 790 755966405 XP_011305489.1 219 2.1e-15 PREDICTED: 60S acidic ribosomal protein P1 [Fopius arisanus] 642922948 XM_967363.3 83 2.51434e-33 PREDICTED: Tribolium castaneum 60S acidic ribosomal protein P1 (LOC661185), mRNA K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P08570 208 1.6e-15 60S acidic ribosomal protein P1 OS=Drosophila melanogaster GN=RpLP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1762 60s acidic ribosomal protein P1 Cluster-8309.34530 BP_3 470.14 7.38 3361 642937688 XP_008198902.1 1087 2.0e-115 PREDICTED: E3 ubiquitin-protein ligase RNF126 isoform X1 [Tribolium castaneum] 170048596 XM_001870670.1 46 4.08891e-12 Culex quinquefasciatus RING finger protein 126-B, mRNA K11982 RNF115_126 E3 ubiquitin-protein ligase RNF115/126 http://www.genome.jp/dbget-bin/www_bget?ko:K11982 Q91YL2 436 2.5e-41 E3 ubiquitin-protein ligase RNF126 OS=Mus musculus GN=Rnf126 PE=1 SV=1 PF13639//PF01155//PF00097//PF12678//PF17123//PF12861//PF14634 Ring finger domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain GO:0016567//GO:0006464 protein ubiquitination//cellular protein modification process GO:0046872//GO:0008270//GO:0016151//GO:0004842//GO:0005515 metal ion binding//zinc ion binding//nickel cation binding//ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.34532 BP_3 4.00 2.74 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34533 BP_3 178.00 3.31 2884 478260599 ENN80302.1 1505 5.7e-164 hypothetical protein YQE_03295, partial [Dendroctonus ponderosae]>gi|546685269|gb|ERL94796.1| hypothetical protein D910_12070 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5TFE4 526 7.8e-52 5'-nucleotidase domain-containing protein 1 OS=Homo sapiens GN=NT5DC1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2470 Similar to IMP-GMP specific 5'-nucleotidase Cluster-8309.34534 BP_3 122.69 0.85 7212 91087491 XP_968373.1 1415 3.9e-153 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] 462366872 APGK01027093.1 51 1.4656e-14 Dendroctonus ponderosae Seq01027103, whole genome shotgun sequence K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 P42765 1078 1.9e-115 3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens GN=ACAA2 PE=1 SV=2 PF02803//PF00108//PF05699 Thiolase, C-terminal domain//Thiolase, N-terminal domain//hAT family C-terminal dimerisation region GO:0008152 metabolic process GO:0046983//GO:0016747 protein dimerization activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.34535 BP_3 4.00 83.40 225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34536 BP_3 1058.00 22.72 2536 91076080 XP_967713.1 925 9.1e-97 PREDICTED: ADP-ribosylation factor 6 [Tribolium castaneum]>gi|270014695|gb|EFA11143.1| hypothetical protein TcasGA2_TC004744 [Tribolium castaneum] 462311205 APGK01047050.1 264 2.00694e-133 Dendroctonus ponderosae Seq01047060, whole genome shotgun sequence K07941 ARF6 ADP-ribosylation factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K07941 P26990 906 5.9e-96 ADP-ribosylation factor 6 OS=Gallus gallus GN=ARF6 PE=2 SV=3 PF01926//PF08477//PF00025//PF01591//PF04881//PF04670//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//6-phosphofructo-2-kinase//Adenovirus GP19K//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit GO:0007165//GO:0050690//GO:0007186//GO:0006000//GO:0006013//GO:0007264 signal transduction//regulation of defense response to virus by virus//G-protein coupled receptor signaling pathway//fructose metabolic process//mannose metabolic process//small GTPase mediated signal transduction GO:0031683//GO:0005537//GO:0005524//GO:0003924//GO:0003873//GO:0004871//GO:0019001//GO:0005525 G-protein beta/gamma-subunit complex binding//mannose binding//ATP binding//GTPase activity//6-phosphofructo-2-kinase activity//signal transducer activity//guanyl nucleotide binding//GTP binding GO:0005622 intracellular KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3) Cluster-8309.34542 BP_3 20.19 0.83 1464 478251391 ENN71857.1 403 1.8e-36 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 P54726 280 1.3e-23 UV excision repair protein RAD23 homolog A OS=Mus musculus GN=Rad23a PE=1 SV=2 PF00995//PF09280 Sec1 family//XPC-binding domain GO:0006904//GO:0006289//GO:0043161//GO:0006281//GO:0016192 vesicle docking involved in exocytosis//nucleotide-excision repair//proteasome-mediated ubiquitin-dependent protein catabolic process//DNA repair//vesicle-mediated transport GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.34544 BP_3 12.00 0.49 1479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12567 Leukocyte receptor CD45 GO:0006470//GO:0006570//GO:0050852 protein dephosphorylation//tyrosine metabolic process//T cell receptor signaling pathway GO:0004725 protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.34545 BP_3 37.25 0.35 5461 478251732 ENN72185.1 487 1.2e-45 hypothetical protein YQE_11170, partial [Dendroctonus ponderosae]>gi|546682227|gb|ERL92188.1| hypothetical protein D910_09508 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q09564 147 1.3e-07 Protein phosphatase PHLPP-like protein OS=Caenorhabditis elegans GN=F43C1.1 PE=3 SV=2 PF02052//PF13855//PF00560 Gallidermin//Leucine rich repeat//Leucine Rich Repeat GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.34546 BP_3 48.00 8.22 573 270013391 EFA09839.1 816 8.9e-85 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 145 2.4e-08 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.34548 BP_3 66.30 0.54 6167 91092168 XP_968081.1 571 2.5e-55 PREDICTED: uncharacterized protein LOC656458 [Tribolium castaneum]>gi|270014443|gb|EFA10891.1| hypothetical protein TcasGA2_TC001715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34549 BP_3 103.09 1.72 3180 642933795 XP_008197323.1 3601 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2199 8.7e-246 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF00437//PF01637//PF00664//PF13304//PF01926//PF00005//PF03193 Type II/IV secretion system protein//Archaeal ATPase//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258 GO:0055085//GO:0006810 transmembrane transport//transport GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.34551 BP_3 9309.16 1947.46 522 91085777 XP_974360.1 705 6.0e-72 PREDICTED: 60S ribosomal protein L23 [Tribolium castaneum]>gi|270010126|gb|EFA06574.1| hypothetical protein TcasGA2_TC009485 [Tribolium castaneum] 110671519 DQ673438.1 168 9.10085e-81 Diaphorina citri putative ribosomal protein L17/23 mRNA, complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 Q9GNE2 669 3.7e-69 60S ribosomal protein L23 OS=Aedes aegypti GN=RpL23-A PE=2 SV=1 PF00238 Ribosomal protein L14p/L23e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.34555 BP_3 47.93 1.86 1537 91079965 XP_969696.1 445 2.5e-41 PREDICTED: 60S ribosomal protein L14 [Tribolium castaneum]>gi|270004603|gb|EFA01051.1| hypothetical protein TcasGA2_TC003967 [Tribolium castaneum] -- -- -- -- -- K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 Q95ZE8 331 1.7e-29 60S ribosomal protein L14 OS=Drosophila virilis GN=RpL14 PE=3 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3421 60S ribosomal protein L14 Cluster-8309.34556 BP_3 169.00 5.09 1893 642910655 XP_008200044.1 1960 6.5e-217 PREDICTED: uncharacterized protein C12orf4 homolog isoform X1 [Tribolium castaneum]>gi|270014514|gb|EFA10962.1| hypothetical protein TcasGA2_TC004122 [Tribolium castaneum] 571513850 XM_394347.5 51 3.79763e-15 PREDICTED: Apis mellifera uncharacterized protein C12orf4 homolog (LOC410871), mRNA -- -- -- -- Q5RD58 930 7.3e-99 Protein C12orf4 homolog OS=Pongo abelii PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4506 Uncharacterized conserved protein Cluster-8309.34557 BP_3 830.60 12.56 3480 805776063 XP_012137915.1 1666 1.5e-182 PREDICTED: eukaryotic translation initiation factor 2-alpha kinase isoform X1 [Megachile rotundata]>gi|805776066|ref|XP_012137916.1| PREDICTED: eukaryotic translation initiation factor 2-alpha kinase isoform X1 [Megachile rotundata] -- -- -- -- -- K08860 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08860 Q9Z1Z1 685 3.5e-70 Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Rattus norvegicus GN=Eif2ak3 PE=1 SV=1 PF10588//PF07714//PF00069//PF06293 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0055114 protein phosphorylation//oxidation-reduction process GO:0016773//GO:0005524//GO:0016491//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//oxidoreductase activity//protein kinase activity GO:0016020 membrane KOG1035 eIF-2alpha kinase GCN2 Cluster-8309.34558 BP_3 94.55 0.93 5207 642925960 XP_008195671.1 2730 9.3e-306 PREDICTED: neurotrypsin-like [Tribolium castaneum]>gi|270009237|gb|EFA05685.1| serine protease P153 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08762 744 7.4e-77 Neurotrypsin OS=Mus musculus GN=Prss12 PE=2 SV=1 PF01380//PF02449//PF15494//PF00089//PF04178//PF00057//PF01607//PF00530 SIS domain//Beta-galactosidase//Scavenger receptor cysteine-rich domain//Trypsin//Got1/Sft2-like family//Low-density lipoprotein receptor domain class A//Chitin binding Peritrophin-A domain//Scavenger receptor cysteine-rich domain GO:0016192//GO:0006030//GO:0007165//GO:0046486//GO:0005975//GO:0006687//GO:0006027//GO:0006012//GO:0006508 vesicle-mediated transport//chitin metabolic process//signal transduction//glycerolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//glycosaminoglycan catabolic process//galactose metabolic process//proteolysis GO:0004565//GO:0004252//GO:0008233//GO:0030246//GO:0005515//GO:0005044//GO:0008061 beta-galactosidase activity//serine-type endopeptidase activity//peptidase activity//carbohydrate binding//protein binding//scavenger receptor activity//chitin binding GO:0009341//GO:0016020//GO:0005576 beta-galactosidase complex//membrane//extracellular region -- -- Cluster-8309.34559 BP_3 2317.95 46.49 2695 478252633 ENN73038.1 1480 4.2e-161 hypothetical protein YQE_10373, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P48594 545 4.6e-54 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34560 BP_3 510.00 20.00 1521 642936612 XP_008198506.1 730 2.2e-74 PREDICTED: uncharacterized protein LOC661523 isoform X2 [Tribolium castaneum]>gi|270013067|gb|EFA09515.1| hypothetical protein TcasGA2_TC011617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34561 BP_3 566.31 7.74 3820 350406035 XP_003487634.1 231 4.1e-16 PREDICTED: pro-resilin [Bombus impatiens] 642925500 XM_963805.3 51 7.73182e-15 PREDICTED: Tribolium castaneum pro-resilin (LOC657340), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34562 BP_3 1235.69 32.63 2117 642916373 XP_008190993.1 925 7.6e-97 PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum]>gi|642916375|ref|XP_008190995.1| PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q6P6R0 539 1.8e-53 Protein lifeguard 1 OS=Rattus norvegicus GN=Grina PE=2 SV=1 PF05393 Human adenovirus early E3A glycoprotein -- -- -- -- GO:0016021 integral component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.34564 BP_3 59.91 1.14 2832 270002093 EEZ98540.1 1018 1.7e-107 hypothetical protein TcasGA2_TC001044 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34565 BP_3 1007.90 22.93 2410 332376166 AEE63223.1 797 6.0e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q86BN8 610 1.2e-61 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Drosophila melanogaster GN=Plip PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1719 Dual specificity phosphatase Cluster-8309.34566 BP_3 6.00 0.42 988 642929422 XP_008195833.1 274 1.1e-21 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02761 CBL proto-oncogene N-terminus, EF hand-like domain -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.34567 BP_3 154.16 1.30 5996 189240170 XP_975082.2 2046 2.2e-226 PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X1 [Tribolium castaneum]>gi|642932079|ref|XP_008196849.1| PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 1037 9.1e-111 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 PF08465//PF13465//PF00096 Thymidine kinase from Herpesvirus C-terminal//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006230//GO:0006206 TMP biosynthetic process//pyrimidine nucleobase metabolic process GO:0046872//GO:0005524//GO:0004797 metal ion binding//ATP binding//thymidine kinase activity -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.34568 BP_3 121.08 4.13 1706 91088707 XP_975095.1 293 1.2e-23 PREDICTED: mitochondrial 2-oxoglutarate/malate carrier protein [Tribolium castaneum]>gi|270012291|gb|EFA08739.1| hypothetical protein TcasGA2_TC006414 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 247 1.0e-19 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.34569 BP_3 598.12 7.41 4181 270014508 EFA10956.1 1385 6.8e-150 hypothetical protein TcasGA2_TC004116 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 P05049 565 3.4e-56 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089//PF01529//PF12422 Trypsin//DHHC palmitoyltransferase//Condensin II non structural maintenance of chromosomes subunit GO:0006508 proteolysis GO:0008270//GO:0004252 zinc ion binding//serine-type endopeptidase activity GO:0005634 nucleus -- -- Cluster-8309.34570 BP_3 1295.02 11.08 5924 270016366 EFA12812.1 392 1.4e-34 hypothetical protein TcasGA2_TC001877 [Tribolium castaneum] 642933104 XM_008199038.1 222 1.05177e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF03485 Arginyl tRNA synthetase N terminal domain GO:0006560//GO:0006525//GO:0006420 proline metabolic process//arginine metabolic process//arginyl-tRNA aminoacylation GO:0004814//GO:0000166//GO:0005524 arginine-tRNA ligase activity//nucleotide binding//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.34572 BP_3 3131.46 34.96 4609 642922013 XP_008192985.1 2785 0.0e+00 PREDICTED: argonaute-2b isoform X1 [Tribolium castaneum] -- -- -- -- -- K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 1392 4.8e-152 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF02926//PF02170//PF02171 THUMP domain//PAZ domain//Piwi domain -- -- GO:0003676//GO:0003723//GO:0005515 nucleic acid binding//RNA binding//protein binding -- -- KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.34573 BP_3 5.00 0.51 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34574 BP_3 230.75 1.29 8940 642934775 XP_008197803.1 5864 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 411 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 3079 0.0e+00 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.34575 BP_3 677.00 9.44 3750 751657251 AJF94884.1 846 1.9e-87 C1 family cathepsin O12 [Tenebrio molitor] -- -- -- -- -- K01374 CTSO cathepsin O http://www.genome.jp/dbget-bin/www_bget?ko:K01374 P43234 529 4.6e-52 Cathepsin O OS=Homo sapiens GN=CTSO PE=2 SV=1 PF03051//PF00112//PF05739//PF05130//PF03661 Peptidase C1-like family//Papain family cysteine protease//SNARE domain//FlgN protein//Uncharacterised protein family (UPF0121) GO:0044780//GO:0006508 bacterial-type flagellum assembly//proteolysis GO:0004197//GO:0005515//GO:0008234 cysteine-type endopeptidase activity//protein binding//cysteine-type peptidase activity GO:0016021 integral component of membrane KOG1542 Cysteine proteinase Cathepsin F Cluster-8309.34576 BP_3 908.94 23.55 2152 646700389 KDR10550.1 1766 2.3e-194 V-type proton ATPase subunit C [Zootermopsis nevadensis] 571527272 XM_006562096.1 219 1.75996e-108 PREDICTED: Apis mellifera vacuolar H[+] ATPase 44kD C subunit (Vha44), transcript variant X2, mRNA K02148 ATPeV1C, ATP6C V-type H+-transporting ATPase subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K02148 Q9U5N1 1628 9.6e-180 V-type proton ATPase subunit C OS=Manduca sexta PE=2 SV=1 PF04799//PF04513//PF03223 fzo-like conserved region//Baculovirus polyhedron envelope protein, PEP, C terminus//V-ATPase subunit C GO:0015991//GO:0008053//GO:0015992 ATP hydrolysis coupled proton transport//mitochondrial fusion//proton transport GO:0003924//GO:0005198//GO:0015078 GTPase activity//structural molecule activity//hydrogen ion transmembrane transporter activity GO:0033180//GO:0019028//GO:0016021//GO:0019031//GO:0005741 proton-transporting V-type ATPase, V1 domain//viral capsid//integral component of membrane//viral envelope//mitochondrial outer membrane KOG2909 Vacuolar H+-ATPase V1 sector, subunit C Cluster-8309.34577 BP_3 62.88 1.35 2535 478257427 ENN77583.1 2415 1.5e-269 hypothetical protein YQE_05879, partial [Dendroctonus ponderosae]>gi|546685706|gb|ERL95167.1| hypothetical protein D910_12436 [Dendroctonus ponderosae] -- -- -- -- -- K00294 E1.2.1.88 1-pyrroline-5-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00294 P30038 1685 2.8e-186 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens GN=ALDH4A1 PE=1 SV=3 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2455 Delta-1-pyrroline-5-carboxylate dehydrogenase Cluster-8309.34578 BP_3 1230.94 33.27 2075 91094127 XP_968492.1 2115 7.6e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 3.3e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0030145//GO:0004177//GO:0008235 manganese ion binding//aminopeptidase activity//metalloexopeptidase activity GO:0005737//GO:0005622 cytoplasm//intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.34579 BP_3 13.00 2.70 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34580 BP_3 834.79 67.37 889 211939884 ACJ13424.1 445 1.4e-41 serpin [Sphenophorus levis] -- -- -- -- -- K04525 SERPINA serpin peptidase inhibitor, clade A http://www.genome.jp/dbget-bin/www_bget?ko:K04525 P22922 299 5.1e-26 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34581 BP_3 46.13 0.70 3467 270010243 EFA06691.1 735 1.3e-74 hypothetical protein TcasGA2_TC009622 [Tribolium castaneum] -- -- -- -- -- K09250 CNBP cellular nucleic acid-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09250 Q8T8R1 419 2.4e-39 CCHC-type zinc finger protein CG3800 OS=Drosophila melanogaster GN=CG3800 PE=1 SV=1 PF00098//PF05733 Zinc knuckle//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0003676//GO:0008270//GO:0003723 nucleic acid binding//zinc ion binding//RNA binding GO:0019013 viral nucleocapsid KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.34582 BP_3 2276.66 23.72 4917 546673472 ERL85070.1 2710 1.8e-303 hypothetical protein D910_02493 [Dendroctonus ponderosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 Q27772 2377 3.1e-266 C-1-tetrahydrofolate synthase, cytoplasmic OS=Spodoptera frugiperda PE=2 SV=3 PF01189//PF09445//PF02882//PF01795//PF05175//PF01268 16S rRNA methyltransferase RsmF//RNA cap guanine-N2 methyltransferase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//MraW methylase family//Methyltransferase small domain//Formate--tetrahydrofolate ligase GO:0055114//GO:0009396//GO:0046487//GO:0001510//GO:0009452 oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//RNA methylation//7-methylguanosine RNA capping GO:0008168//GO:0004488//GO:0003824//GO:0005524//GO:0004329 methyltransferase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//ATP binding//formate-tetrahydrofolate ligase activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.34584 BP_3 18.72 2.28 688 312306040 ADQ73873.1 532 9.1e-52 receptor for activated protein kinase C [Laodelphax striatella] -- -- -- -- -- K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 455 3.2e-44 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400//PF16974 WD domain, G-beta repeat//High-affinity nitrate transporter accessory GO:0010167//GO:0015706 response to nitrate//nitrate transport GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.34585 BP_3 110.78 1.48 3889 91089633 XP_973579.1 1641 1.3e-179 PREDICTED: guanine nucleotide-binding protein subunit beta-like protein isoform X1 [Tribolium castaneum]>gi|270012613|gb|EFA09061.1| hypothetical protein TcasGA2_TC006776 [Tribolium castaneum] 389610732 AK402355.1 167 2.58277e-79 Papilio polytes mRNA for receptor of activated protein kinase C 1, complete cds, sequence id: Pp-0111 K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1482 1.5e-162 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.34586 BP_3 296.00 2.59 5806 3123007 Q05808.1 3676 0.0e+00 RecName: Full=Vitellogenin; Contains: RecName: Full=YP47; Contains: RecName: Full=YP160; Flags: Precursor [Anthonomus grandis]>gi|155708|gb|AAA27740.1| vitellogenin [Anthonomus grandis] -- -- -- -- -- -- -- -- -- Q05808 3676 0.0e+00 Vitellogenin OS=Anthonomus grandis GN=VTG PE=3 SV=1 PF04551//PF09172//PF01347 GcpE protein//Domain of unknown function (DUF1943)//Lipoprotein amino terminal region GO:0016114//GO:0055114//GO:0006869 terpenoid biosynthetic process//oxidation-reduction process//lipid transport GO:0046429//GO:0005319 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//lipid transporter activity -- -- -- -- Cluster-8309.34588 BP_3 3308.00 96.62 1942 91093052 XP_967459.1 2418 5.2e-270 PREDICTED: T-complex protein 1 subunit eta [Tribolium castaneum]>gi|270002664|gb|EEZ99111.1| hypothetical protein TcasGA2_TC005004 [Tribolium castaneum] 545560918 XM_003640315.2 61 1.07609e-20 PREDICTED: Canis lupus familiaris T-complex protein 1 subunit eta-like (LOC100856782), mRNA K09499 CCT7 T-complex protein 1 subunit eta http://www.genome.jp/dbget-bin/www_bget?ko:K09499 Q5ZJK8 2081 2.6e-232 T-complex protein 1 subunit eta OS=Gallus gallus GN=CCT7 PE=1 SV=1 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0005737 cytoplasm KOG0361 Chaperonin complex component, TCP-1 eta subunit (CCT7) Cluster-8309.34589 BP_3 43.58 0.65 3507 546684212 ERL93917.1 726 1.5e-73 hypothetical protein D910_11203 [Dendroctonus ponderosae] -- -- -- -- -- K03258 EIF4B translation initiation factor 4B http://www.genome.jp/dbget-bin/www_bget?ko:K03258 P23588 385 2.1e-35 Eukaryotic translation initiation factor 4B OS=Homo sapiens GN=EIF4B PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.34590 BP_3 541.85 18.47 1706 780582621 AJZ68869.1 1775 1.7e-195 nicotinic acetylcholine receptor alpha 10 [Leptinotarsa decemlineata] -- -- -- -- -- K04809 CHRNA7 nicotinic acetylcholine receptor alpha-7 http://www.genome.jp/dbget-bin/www_bget?ko:K04809 P48180 545 2.9e-54 Acetylcholine receptor subunit alpha-type acr-16 OS=Caenorhabditis elegans GN=acr-16 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3646 Acetylcholine receptor Cluster-8309.34592 BP_3 123.14 1.05 5970 642918534 XP_008191512.1 3568 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 2440 1.9e-273 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02480//PF16656//PF00041//PF13895//PF00018//PF16794//PF14604 Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//SH3 domain//Fibronectin-III type domain//Variant SH3 domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding GO:0016020 membrane -- -- Cluster-8309.34593 BP_3 114.56 0.79 7238 478257411 ENN77567.1 2274 9.7e-253 hypothetical protein YQE_05863, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9I7U4 1475 1.8e-161 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF16794//PF02480//PF08145//PF14604//PF00018//PF13895//PF00041//PF16656 Fibronectin-III type domain//Alphaherpesvirus glycoprotein E//BOP1NT (NUC169) domain//Variant SH3 domain//SH3 domain//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006364//GO:0006771//GO:0019497 rRNA processing//riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding GO:0016020 membrane -- -- Cluster-8309.34594 BP_3 1165.42 24.17 2616 91081923 XP_970724.1 1473 2.7e-160 PREDICTED: dnaJ homolog subfamily A member 2 [Tribolium castaneum]>gi|270007352|gb|EFA03800.1| hypothetical protein TcasGA2_TC013913 [Tribolium castaneum] 642921669 XM_965631.3 47 8.82761e-13 PREDICTED: Tribolium castaneum dnaJ homolog subfamily A member 2 (LOC659314), mRNA K09503 DNAJA2 DnaJ homolog subfamily A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09503 O60884 1120 9.4e-121 DnaJ homolog subfamily A member 2 OS=Homo sapiens GN=DNAJA2 PE=1 SV=1 PF00684//PF01155//PF11023 DnaJ central domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-ribbon containing domain GO:0009408//GO:0006457//GO:0006464//GO:0006260 response to heat//protein folding//cellular protein modification process//DNA replication GO:0016151//GO:0031072//GO:0005524//GO:0046872//GO:0051082 nickel cation binding//heat shock protein binding//ATP binding//metal ion binding//unfolded protein binding GO:0005887//GO:0005737 integral component of plasma membrane//cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.34595 BP_3 5537.84 27.02 10172 270003787 EFA00235.1 2422 9.4e-270 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 462304009 APGK01049651.1 110 3.29685e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 871 2.7e-91 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF03193//PF00005//PF02899//PF08176//PF01637//PF16656//PF13895//PF00041//PF00621//PF00069//PF13304//PF01926//PF01061//PF07714//PF03931 Protein of unknown function, DUF258//ABC transporter//Phage integrase, N-terminal SAM-like domain//Small acid-soluble spore protein K family//Archaeal ATPase//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain//RhoGEF domain//Protein kinase domain//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter//Protein tyrosine kinase//Skp1 family, tetramerisation domain GO:0015074//GO:0006511//GO:0043087//GO:0006771//GO:0030436//GO:0006468//GO:0019497//GO:0035023 DNA integration//ubiquitin-dependent protein catabolic process//regulation of GTPase activity//riboflavin metabolic process//asexual sporulation//protein phosphorylation//hexachlorocyclohexane metabolic process//regulation of Rho protein signal transduction GO:0005089//GO:0004672//GO:0046872//GO:0005525//GO:0005515//GO:0003677//GO:0003993//GO:0016887//GO:0003924//GO:0005524 Rho guanyl-nucleotide exchange factor activity//protein kinase activity//metal ion binding//GTP binding//protein binding//DNA binding//acid phosphatase activity//ATPase activity//GTPase activity//ATP binding GO:0016020//GO:0042601 membrane//endospore-forming forespore -- -- Cluster-8309.34596 BP_3 7.00 1.01 627 546676782 ERL87728.1 287 2.1e-23 hypothetical protein D910_05118 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34597 BP_3 1025.19 21.92 2546 642917018 XP_008199599.1 757 2.8e-77 PREDICTED: uncharacterized protein LOC661444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y530 373 3.8e-34 O-acetyl-ADP-ribose deacetylase 1 OS=Homo sapiens GN=OARD1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34598 BP_3 503.00 18.91 1574 625199970 XP_007641880.1 177 3.1e-10 PREDICTED: putative uncharacterized protein DDB_G0282133 isoform X1 [Cricetulus griseus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34600 BP_3 860.51 40.45 1317 546681897 ERL91906.1 554 4.9e-54 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 364 2.2e-33 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34602 BP_3 28.16 3.99 632 91080277 XP_973754.1 673 3.7e-68 PREDICTED: iron/zinc purple acid phosphatase-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5D6U8 467 1.2e-45 Iron/zinc purple acid phosphatase-like protein OS=Danio rerio GN=papl PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1378 Purple acid phosphatase Cluster-8309.34604 BP_3 890.60 21.33 2304 642928317 XP_971226.2 1703 5.0e-187 PREDICTED: protein arginine N-methyltransferase 1 isoform X1 [Tribolium castaneum] 795023681 XM_012005633.1 138 2.01033e-63 PREDICTED: Vollenhovia emeryi protein arginine N-methyltransferase 1 (LOC105558112), transcript variant X2, mRNA K11434 PRMT1 protein arginine N-methyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11434 Q99873 1351 1.4e-147 Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=1 SV=2 PF05175//PF01135//PF08241//PF02390 Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase domain//Putative methyltransferase GO:0009451//GO:0006479//GO:0046500//GO:0008033//GO:0006400//GO:0008152//GO:0006464 RNA modification//protein methylation//S-adenosylmethionine metabolic process//tRNA processing//tRNA modification//metabolic process//cellular protein modification process GO:0004719//GO:0008176//GO:0008168 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.34605 BP_3 1045.00 171.71 585 357625019 EHJ75575.1 277 2.9e-22 ribosomal protein L39 [Danaus plexippus] -- -- -- -- -- K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 Q962S4 271 5.9e-23 60S ribosomal protein L39 OS=Spodoptera frugiperda GN=RpL39 PE=3 SV=1 PF00832 Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0002 60s ribosomal protein L39 Cluster-8309.34606 BP_3 3200.10 32.95 4973 642938457 XP_008199811.1 4218 0.0e+00 PREDICTED: Niemann-Pick C1 protein isoform X2 [Tribolium castaneum] 657584210 XM_008298026.1 55 6.02846e-17 PREDICTED: Stegastes partitus Niemann-Pick disease, type C1 (npc1), transcript variant X2, mRNA K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 P56941 2274 2.7e-254 Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1 PF03176//PF02460//PF07677 MMPL family//Patched family//A-macroglobulin receptor GO:0007165 signal transduction GO:0008158 hedgehog receptor activity GO:0005576//GO:0016020 extracellular region//membrane KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.34608 BP_3 39.18 0.35 5695 642934848 XP_008197836.1 1626 1.1e-177 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.87245e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA -- -- -- -- Q5JR59 239 2.9e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34609 BP_3 187.74 4.81 2173 642913197 XP_008201432.1 1434 7.4e-156 PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913199|ref|XP_008201433.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913201|ref|XP_008201434.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 790 1.4e-82 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.34613 BP_3 326.00 4.56 3736 664776039 XP_008507292.1 315 7.2e-26 PREDICTED: zinc finger protein 709-like isoform X1 [Equus przewalskii] 817207063 XM_012424074.1 162 1.4927e-76 PREDICTED: Orussus abietinus zinc finger protein 628 (LOC105699228), transcript variant X3, mRNA K09219 SCRT scratch http://www.genome.jp/dbget-bin/www_bget?ko:K09219 Q13360 288 4.0e-24 Zinc finger protein 177 OS=Homo sapiens GN=ZNF177 PE=1 SV=4 PF02892//PF13912//PF16622//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.34614 BP_3 1101.07 9.56 5842 642915997 XP_008190849.1 3607 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 306 2.09165e-156 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 919 4.3e-97 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF07714//PF06293//PF00069//PF13895//PF00041//PF02480//PF16656 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Immunoglobulin domain//Fibronectin type III domain//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497//GO:0006468 riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0004672//GO:0046872//GO:0003993//GO:0016773//GO:0005515//GO:0005524 protein kinase activity//metal ion binding//acid phosphatase activity//phosphotransferase activity, alcohol group as acceptor//protein binding//ATP binding GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.34615 BP_3 6.00 0.36 1099 332372558 AEE61421.1 573 2.6e-56 unknown [Dendroctonus ponderosae] 755974447 XM_011309028.1 82 1.27394e-32 PREDICTED: Fopius arisanus troponin C, isoform 1-like (LOC105269052), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47947 525 3.9e-52 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF13202//PF08771//PF00036//PF11504//PF12763//PF13833//PF13405//PF13499 EF hand//Rapamycin binding domain//EF hand//Colicin Ia//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0005515//GO:0008144//GO:0005509 protein binding//drug binding//calcium ion binding GO:0016021 integral component of membrane KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.34616 BP_3 588.00 21.98 1581 332373530 AEE61906.1 1598 5.2e-175 unknown [Dendroctonus ponderosae] 695145358 XM_009501769.1 74 5.17663e-28 PREDICTED: Phalacrocorax carbo polymerase (DNA-directed), delta interacting protein 2 (POLDIP2), partial mRNA K17809 POLDIP2 polymerase delta-interacting protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17809 Q91VA6 1137 6.1e-123 Polymerase delta-interacting protein 2 OS=Mus musculus GN=Poldip2 PE=2 SV=1 PF08755 Hemimethylated DNA-binding protein YccV like -- -- GO:0003677 DNA binding -- -- KOG4408 Putative Mg2+ and Co2+ transporter CorD Cluster-8309.34617 BP_3 6229.76 113.25 2943 189235372 XP_968511.2 1112 2.2e-118 PREDICTED: nucleobindin-2 [Tribolium castaneum]>gi|270004247|gb|EFA00695.1| hypothetical protein TcasGA2_TC003574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80303 492 7.0e-48 Nucleobindin-2 OS=Homo sapiens GN=NUCB2 PE=1 SV=2 PF13499//PF13405//PF13833//PF00036//PF13202 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG3866 DNA-binding protein of the nucleobindin family Cluster-8309.34618 BP_3 1654.33 39.14 2329 546684814 ERL94396.1 1115 7.7e-119 hypothetical protein D910_11675 [Dendroctonus ponderosae] 242003302 XM_002422642.1 118 2.66665e-52 Pediculus humanus corporis histone deacetylase complex subunit SAP30, putative, mRNA K03678 RRP45, EXOSC9 exosome complex component RRP45 http://www.genome.jp/dbget-bin/www_bget?ko:K03678 Q4QR75 726 4.1e-75 Exosome complex component RRP45 OS=Rattus norvegicus GN=Exosc9 PE=2 SV=1 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.34620 BP_3 1229.03 41.02 1736 189238341 XP_966817.2 1777 9.9e-196 PREDICTED: sorting and assembly machinery component 50 homolog [Tribolium castaneum] -- -- -- -- -- K07277 SAM50, TOB55, bamA outer membrane protein insertion porin family http://www.genome.jp/dbget-bin/www_bget?ko:K07277 Q6PA35 910 1.4e-96 Sorting and assembly machinery component 50 homolog B OS=Xenopus laevis GN=samm50-b PE=2 SV=1 PF01103 Surface antigen -- -- -- -- GO:0019867 outer membrane KOG2602 Predicted cell surface protein homologous to bacterial outer membrane proteins Cluster-8309.34622 BP_3 49.54 0.73 3583 674656867 AIL26080.1 753 1.1e-76 muscle LIM protein, partial [Monochamus alternatus] 674656866 KJ872589.1 285 6.02988e-145 Monochamus alternatus muscle LIM protein mRNA, partial cds K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 531 2.6e-52 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.34623 BP_3 8.00 0.47 1115 755929162 XP_011309787.1 1069 8.0e-114 PREDICTED: rap guanine nucleotide exchange factor 6-like isoform X6 [Fopius arisanus] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 Q9Y4G8 846 2.4e-89 Rap guanine nucleotide exchange factor 2 OS=Homo sapiens GN=RAPGEF2 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.34624 BP_3 184.15 5.63 1868 478251528 ENN71990.1 1720 4.4e-189 hypothetical protein YQE_11281, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H8E8 659 1.9e-67 Cysteine-rich protein 2-binding protein OS=Homo sapiens GN=CSRP2BP PE=1 SV=3 PF13673//PF02576//PF00130//PF00628//PF16866//PF00583//PF13508//PF08445 Acetyltransferase (GNAT) domain//Putative ribosome maturation factor RimP//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//PHD-finger//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967//GO:0035556//GO:0042274 acyl-carrier-protein biosynthetic process//intracellular signal transduction//ribosomal small subunit biogenesis GO:0016747//GO:0005515//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//N-acetyltransferase activity -- -- -- -- Cluster-8309.34625 BP_3 24.38 0.32 3967 270003759 EFA00207.1 1132 1.4e-120 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.73262e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.34626 BP_3 24.09 0.57 2311 91088343 XP_971105.1 967 1.1e-101 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] 755959155 XM_011306001.1 54 9.99882e-17 PREDICTED: Fopius arisanus 60S ribosomal protein L38 (LOC105267271), mRNA K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 670 1.3e-68 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF01370//PF01781//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ribosomal L38e protein family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0042254//GO:0008152//GO:0006412 oxidation-reduction process//ribosome biogenesis//metabolic process//translation GO:0003735//GO:0000166//GO:0003824//GO:0050662//GO:0016491 structural constituent of ribosome//nucleotide binding//catalytic activity//coenzyme binding//oxidoreductase activity GO:0005622//GO:0005840 intracellular//ribosome KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.34628 BP_3 36.73 1.80 1278 332374670 AEE62476.1 724 9.3e-74 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9LZG0 383 1.3e-35 Adenosine kinase 2 OS=Arabidopsis thaliana GN=ADK2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.34629 BP_3 155.87 1.77 4535 340723524 XP_003400139.1 296 1.4e-23 PREDICTED: NF-kappa-B essential modulator [Bombus terrestris]>gi|808137173|ref|XP_012170874.1| PREDICTED: NF-kappa-B essential modulator [Bombus terrestris]>gi|808137175|ref|XP_012170875.1| PREDICTED: NF-kappa-B essential modulator [Bombus terrestris] -- -- -- -- -- -- -- -- -- O88522 176 4.7e-11 NF-kappa-B essential modulator OS=Mus musculus GN=Ikbkg PE=1 SV=2 PF06160//PF13912//PF07651//PF02183//PF08287//PF00096//PF10186//PF13851 Septation ring formation regulator, EzrA//C2H2-type zinc finger//ANTH domain//Homeobox associated leucine zipper//Spc19//Zinc finger, C2H2 type//Vacuolar sorting 38 and autophagy-related subunit 14//Growth-arrest specific micro-tubule binding GO:0010508//GO:0008608//GO:0006355//GO:0048870//GO:0000921 positive regulation of autophagy//attachment of spindle microtubules to kinetochore//regulation of transcription, DNA-templated//cell motility//septin ring assembly GO:0046872//GO:0003700//GO:0043565//GO:0005543 metal ion binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//phospholipid binding GO:0005876//GO:0042729//GO:0005940//GO:0005667//GO:0031514//GO:0016021 spindle microtubule//DASH complex//septin ring//transcription factor complex//motile cilium//integral component of membrane -- -- Cluster-8309.34631 BP_3 9.32 0.63 1010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34632 BP_3 4829.76 218.32 1358 817216753 XP_012284387.1 893 2.5e-93 PREDICTED: peroxiredoxin 1 [Orussus abietinus]>gi|817216756|ref|XP_012284388.1| PREDICTED: peroxiredoxin 1 [Orussus abietinus] 533529372 KC197034.1 70 7.41285e-26 Rhodeus uyekii peroxiredoxin 1 mRNA, complete cds K13279 PRDX1 peroxiredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13279 Q9V3P0 799 8.1e-84 Peroxiredoxin 1 OS=Drosophila melanogaster GN=Jafrac1 PE=1 SV=1 PF00578//PF08534//PF10417 AhpC/TSA family//Redoxin//C-terminal domain of 1-Cys peroxiredoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0051920//GO:0016491 antioxidant activity//peroxiredoxin activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.34634 BP_3 722.15 44.33 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34636 BP_3 6.00 0.86 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34637 BP_3 1088.78 7.10 7688 642918117 XP_008194070.1 4807 0.0e+00 PREDICTED: ALK tyrosine kinase receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 1478 8.5e-162 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 PF00069//PF00629//PF07714//PF00057 Protein kinase domain//MAM domain, meprin/A5/mu//Protein tyrosine kinase//Low-density lipoprotein receptor domain class A GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding GO:0016020 membrane KOG1095 Protein tyrosine kinase Cluster-8309.34638 BP_3 2.00 1.52 350 108794573 ABG20822.1 338 1.4e-29 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 266 1.3e-22 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.34639 BP_3 4204.37 35.05 6073 91090364 XP_968231.1 1683 2.8e-184 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5U6 614 1.0e-61 RING finger protein 10 OS=Homo sapiens GN=RNF10 PE=1 SV=2 PF04728//PF00097//PF02891//PF14634//PF13639//PF00351 Lipoprotein leucine-zipper//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger//zinc-RING finger domain//Ring finger domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0055114 oxidation-reduction process GO:0005515//GO:0046872//GO:0008270//GO:0016714 protein binding//metal ion binding//zinc ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0019867 outer membrane KOG2164 Predicted E3 ubiquitin ligase Cluster-8309.34640 BP_3 68.25 1.10 3274 350419978 XP_003492359.1 3053 0.0e+00 PREDICTED: leucine-zipper-like transcriptional regulator 1 [Bombus impatiens] 527245427 XM_005140996.1 147 2.84775e-68 PREDICTED: Melopsittacus undulatus leucine-zipper-like transcription regulator 1 (LOC101875977), partial mRNA -- -- -- -- Q8N653 1423 8.6e-156 Leucine-zipper-like transcriptional regulator 1 OS=Homo sapiens GN=LZTR1 PE=1 SV=2 PF03089//PF11648//PF01344//PF00651//PF07646 Recombination activating protein 2//C-terminal domain of RIG-I//Kelch motif//BTB/POZ domain//Kelch motif GO:0006310 DNA recombination GO:0003677//GO:0005515//GO:0016817 DNA binding//protein binding//hydrolase activity, acting on acid anhydrides GO:0005634 nucleus KOG0379 Kelch repeat-containing proteins Cluster-8309.34641 BP_3 23.68 0.32 3909 91088677 XP_974860.1 1600 7.5e-175 PREDICTED: probable aconitate hydratase, mitochondrial [Tribolium castaneum]>gi|270011673|gb|EFA08121.1| hypothetical protein TcasGA2_TC005725 [Tribolium castaneum] 198476819 XM_001357457.2 167 2.59617e-79 Drosophila pseudoobscura pseudoobscura GA21639 (Dpse\GA21639), partial mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 Q99KI0 1429 2.1e-156 Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1 PF00694 Aconitase C-terminal domain GO:0008152//GO:0006099//GO:0046487//GO:0019643 metabolic process//tricarboxylic acid cycle//glyoxylate metabolic process//reductive tricarboxylic acid cycle GO:0003994//GO:0051539 aconitate hydratase activity//4 iron, 4 sulfur cluster binding -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.34643 BP_3 370.11 8.80 2318 91083815 XP_973428.1 297 5.5e-24 PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924518|ref|XP_008194328.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924520|ref|XP_008194329.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|270007930|gb|EFA04378.1| hypothetical protein TcasGA2_TC014676 [Tribolium castaneum] 242011614 XM_002426498.1 39 2.18643e-08 Pediculus humanus corporis hypothetical protein, mRNA K11587 CBX5, HP1A chromobox protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11587 P45973 246 1.8e-19 Chromobox protein homolog 5 OS=Homo sapiens GN=CBX5 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.34645 BP_3 111.57 1.63 3598 242005288 XP_002423502.1 747 5.6e-76 beat protein, putative [Pediculus humanus corporis]>gi|212506606|gb|EEB10764.1| beat protein, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.34646 BP_3 53.99 1.14 2565 642920869 XP_008192593.1 2055 8.5e-228 PREDICTED: protein turtle isoform X8 [Tribolium castaneum] 642920870 XM_008194372.1 186 4.65052e-90 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X14, mRNA -- -- -- -- Q967D7 747 1.6e-77 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF00041//PF07353 Tissue factor//Fibronectin type III domain//Uroplakin II GO:0061024 membrane organization GO:0005515 protein binding GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.34647 BP_3 339.00 3.86 4525 642924813 XP_008194051.1 4008 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X3 [Tribolium castaneum] 749755570 XM_011141969.1 132 8.60654e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.7e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 PF01092//PF00569 Ribosomal protein S6e//Zinc finger, ZZ type GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2372 Oxidation resistance protein Cluster-8309.34648 BP_3 1439.16 21.11 3578 91079020 XP_974879.1 2869 0.0e+00 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q863B3 1618 2.3e-178 Staphylococcal nuclease domain-containing protein 1 OS=Bos taurus GN=SND1 PE=1 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.34651 BP_3 2149.31 36.95 3095 91077276 XP_974294.1 519 1.3e-49 PREDICTED: cytochrome b5 [Tribolium castaneum]>gi|270002076|gb|EEZ98523.1| hypothetical protein TcasGA2_TC001027 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4N3 380 7.1e-35 Cytochrome b5 OS=Drosophila melanogaster GN=Cyt-b5 PE=2 SV=1 -- -- -- -- GO:0020037//GO:0046872 heme binding//metal ion binding -- -- KOG0537 Cytochrome b5 Cluster-8309.34652 BP_3 757.96 252.19 436 646721191 KDR22661.1 265 5.3e-21 Protein transport protein Sec61 subunit gamma [Zootermopsis nevadensis] -- -- -- -- -- K07342 SEC61G, SSS1, secE protein transport protein SEC61 subunit gamma and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K07342 Q7Z1B8 266 1.7e-22 Protein transport protein Sec61 subunit gamma OS=Gryllotalpa orientalis GN=SEC61G PE=3 SV=1 PF00584 SecE/Sec61-gamma subunits of protein translocation complex GO:0006886//GO:0006605 intracellular protein transport//protein targeting -- -- GO:0016020 membrane KOG3498 Preprotein translocase, gamma subunit Cluster-8309.34653 BP_3 9.30 0.46 1276 91086581 XP_973438.1 571 5.1e-56 PREDICTED: derlin-1 [Tribolium castaneum]>gi|270010357|gb|EFA06805.1| hypothetical protein TcasGA2_TC009744 [Tribolium castaneum] -- -- -- -- -- K11519 DERL1 Derlin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11519 Q99J56 445 8.5e-43 Derlin-1 OS=Mus musculus GN=Derl1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0858 Predicted membrane protein Cluster-8309.34654 BP_3 86.13 0.64 6828 642922371 XP_008193129.1 2275 7.0e-253 PREDICTED: insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.95874e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 O88477 962 5.1e-102 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Mus musculus GN=Igf2bp1 PE=1 SV=1 PF00013//PF13184//PF13014//PF00076//PF04061//PF07650 KH domain//NusA-like KH domain//KH domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//ORMDL family//KH domain -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.34655 BP_3 80.00 15.40 542 443709651 ELU04243.1 290 8.3e-24 hypothetical protein CAPTEDRAFT_219882 [Capitella teleta] -- -- -- -- -- -- -- -- -- Q868Z9 261 7.9e-22 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.34657 BP_3 276.00 67.70 488 332374588 AEE62435.1 392 1.1e-35 unknown [Dendroctonus ponderosae]>gi|546684934|gb|ERL94516.1| hypothetical protein D910_11793 [Dendroctonus ponderosae] -- -- -- -- -- K17780 TIM8 mitochondrial import inner membrane translocase subunit TIM8 http://www.genome.jp/dbget-bin/www_bget?ko:K17780 Q9Y1A3 324 3.5e-29 Mitochondrial import inner membrane translocase subunit Tim8 OS=Drosophila melanogaster GN=Tim8 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3489 Mitochondrial import inner membrane translocase, subunit TIM8 Cluster-8309.34660 BP_3 806.30 6.03 6739 642919776 XP_008192060.1 5683 0.0e+00 PREDICTED: multidrug resistance-associated protein 7 [Tribolium castaneum] -- -- -- -- -- K05674 ABCC10 ATP-binding cassette, subfamily C (CFTR/MRP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05674 Q5T3U5 2041 3.9e-227 Multidrug resistance-associated protein 7 OS=Homo sapiens GN=ABCC10 PE=1 SV=1 PF03193//PF00005//PF13304//PF01926//PF00664//PF00004 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//ATPase family associated with various cellular activities (AAA) GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.34661 BP_3 8033.78 1411.44 566 478255228 ENN75457.1 681 4.0e-69 hypothetical protein YQE_08007, partial [Dendroctonus ponderosae] 677286677 KJ930032.1 338 3.11957e-175 Monochamus alternatus ribosomal protein S15A (RpS15A) mRNA, complete cds K02957 RP-S15Ae, RPS15A small subunit ribosomal protein S15Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02957 Q6XIM8 652 3.8e-67 40S ribosomal protein S15a OS=Drosophila yakuba GN=RpS15Aa PE=2 SV=3 PF00410 Ribosomal protein S8 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1754 40S ribosomal protein S15/S22 Cluster-8309.34662 BP_3 69.17 1.63 2341 91084337 XP_972793.1 670 3.1e-67 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 4.36043e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 476 4.0e-46 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 PF05478 Prominin GO:0006457 protein folding GO:0031072//GO:0051082 heat shock protein binding//unfolded protein binding GO:0016021 integral component of membrane KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.34665 BP_3 34.50 1.96 1140 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34667 BP_3 73.83 0.92 4171 546671568 ERL83830.1 695 7.0e-70 hypothetical protein D910_01082, partial [Dendroctonus ponderosae] -- -- -- -- -- K17552 PPP1R10 protein phosphatase 1 regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K17552 O55000 234 8.2e-18 Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Rattus norvegicus GN=Ppp1r10 PE=1 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.34668 BP_3 2273.81 30.28 3911 546671568 ERL83830.1 695 6.5e-70 hypothetical protein D910_01082, partial [Dendroctonus ponderosae] -- -- -- -- -- K17552 PPP1R10 protein phosphatase 1 regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K17552 O55000 234 7.7e-18 Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Rattus norvegicus GN=Ppp1r10 PE=1 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.34669 BP_3 3077.44 47.58 3409 91081301 XP_968960.1 3902 0.0e+00 PREDICTED: glycogen phosphorylase [Tribolium castaneum]>gi|270006093|gb|EFA02541.1| hypothetical protein TcasGA2_TC008246 [Tribolium castaneum] 817087305 XM_012410997.1 451 0 PREDICTED: Athalia rosae glycogen phosphorylase (LOC105692065), mRNA K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 P11216 3201 0.0e+00 Glycogen phosphorylase, brain form OS=Homo sapiens GN=PYGB PE=1 SV=5 PF00343 Carbohydrate phosphorylase GO:0005975 carbohydrate metabolic process GO:0030170//GO:0008184 pyridoxal phosphate binding//glycogen phosphorylase activity -- -- KOG2099 Glycogen phosphorylase Cluster-8309.34670 BP_3 38.61 0.36 5465 332375705 AEE62993.1 1310 4.4e-141 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01619 deoC, DERA deoxyribose-phosphate aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01619 Q9Y315 954 3.5e-101 Deoxyribose-phosphate aldolase OS=Homo sapiens GN=DERA PE=1 SV=2 PF01791//PF00651//PF00096 DeoC/LacD family aldolase//BTB/POZ domain//Zinc finger, C2H2 type -- -- GO:0016829//GO:0005515//GO:0046872 lyase activity//protein binding//metal ion binding -- -- KOG3981 Deoxyribose-phosphate aldolase Cluster-8309.34672 BP_3 7806.36 170.00 2505 270006955 EFA03403.1 2958 0.0e+00 hypothetical protein TcasGA2_TC013390 [Tribolium castaneum] 347966055 XM_321614.4 107 3.74055e-46 Anopheles gambiae str. PEST AGAP001507-PA (AgaP_AGAP001507) mRNA, complete cds K13647 PLODN procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K13647 Q5U367 1892 2.7e-210 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 OS=Rattus norvegicus GN=Plod3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1971 Lysyl hydroxylase Cluster-8309.34673 BP_3 927.29 59.81 1039 817079505 XP_012262173.1 280 2.3e-22 PREDICTED: zinc finger protein 706-like [Athalia rosae]>gi|817079507|ref|XP_012262174.1| PREDICTED: zinc finger protein 706-like [Athalia rosae] 389609616 AK401798.1 81 4.32376e-32 Papilio xuthus mRNA for similar to CG15715, complete cds, sequence id: Px-1382 -- -- -- -- Q5ZMM5 201 1.4e-14 Zinc finger protein 706 OS=Gallus gallus GN=ZNF706 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4118 Uncharacterized conserved protein Cluster-8309.34675 BP_3 15.00 27.03 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34676 BP_3 49.19 0.62 4139 642915549 XP_008190662.1 1295 1.8e-139 PREDICTED: RNA-binding protein 25 isoform X1 [Tribolium castaneum]>gi|270003846|gb|EFA00294.1| hypothetical protein TcasGA2_TC003127 [Tribolium castaneum] 572312960 XM_006622122.1 71 6.38989e-26 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 3.3e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076//PF01480 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PWI domain GO:0006397 mRNA processing GO:0003676 nucleic acid binding -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.34677 BP_3 237.00 17.15 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34679 BP_3 1573.00 21.26 3858 91076160 XP_966582.1 1501 2.2e-163 PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911736|ref|XP_008200719.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911739|ref|XP_008200720.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911741|ref|XP_008200721.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|270014726|gb|EFA11174.1| hypothetical protein TcasGA2_TC004781 [Tribolium castaneum] 501299748 AK418324.1 84 3.53202e-33 Riptortus pedestris mRNA for ubiquilin 1,2, partial cds, sequence id: Rped-0553, expressed in midgut K04523 UBQLN, DSK2 ubiquilin http://www.genome.jp/dbget-bin/www_bget?ko:K04523 Q5R684 899 5.9e-95 Ubiquilin-1 OS=Pongo abelii GN=UBQLN1 PE=2 SV=1 PF01801//PF00240//PF06112 Cytomegalovirus glycoprotein L//Ubiquitin family//Gammaherpesvirus capsid protein GO:0016032 viral process GO:0005515 protein binding GO:0019028//GO:0019031 viral capsid//viral envelope KOG0010 Ubiquitin-like protein Cluster-8309.34680 BP_3 1187.52 5.13 11455 642935540 XP_008198051.1 1716 7.8e-188 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X5 [Tribolium castaneum] 755889203 XM_005188558.2 102 1.04002e-42 PREDICTED: Musca domestica vesicular integral-membrane protein VIP36 (LOC101894935), mRNA K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q7L273 996 9.8e-106 BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens GN=KCTD9 PE=1 SV=1 PF00139//PF02214//PF03388//PF03120 Legume lectin domain//BTB/POZ domain//Legume-like lectin family//NAD-dependent DNA ligase OB-fold domain GO:0006260//GO:0006281//GO:0051260 DNA replication//DNA repair//protein homooligomerization GO:0030246//GO:0003911 carbohydrate binding//DNA ligase (NAD+) activity GO:0016020 membrane KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.34681 BP_3 1178.15 6.76 8690 270014822 EFA11270.1 5242 0.0e+00 hypothetical protein TcasGA2_TC010805 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4083 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF04689//PF03808//PF08074//PF04851//PF00176 DNA binding protein S1FA//Glycosyl transferase WecB/TagA/CpsF family//CHDCT2 (NUC038) domain//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain GO:0009058//GO:0006355 biosynthetic process//regulation of transcription, DNA-templated GO:0005524//GO:0016787//GO:0003677//GO:0016818//GO:0008270 ATP binding//hydrolase activity//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.34682 BP_3 1325.86 20.55 3401 642928069 XP_968571.3 1658 1.2e-181 PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|642928071|ref|XP_008200143.1| PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|270010871|gb|EFA07319.1| hypothetical protein TcasGA2_TC015912 [Tribolium castaneum] -- -- -- -- -- K01581 E4.1.1.17, ODC1, speC, speF ornithine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01581 P27117 1033 1.5e-110 Ornithine decarboxylase OS=Bos taurus GN=ODC1 PE=2 SV=1 PF00278//PF02784 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Pyridoxal-dependent decarboxylase, pyridoxal binding domain GO:0006596 polyamine biosynthetic process GO:0003824 catalytic activity -- -- KOG0622 Ornithine decarboxylase Cluster-8309.34684 BP_3 6.72 0.56 873 478260464 ENN80184.1 268 4.8e-21 hypothetical protein YQE_03380, partial [Dendroctonus ponderosae]>gi|546674446|gb|ERL85820.1| hypothetical protein D910_03235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34686 BP_3 42.78 0.47 4641 642915700 XP_008190765.1 3282 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X3 [Tribolium castaneum] 642915699 XM_008192543.1 222 8.22592e-110 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 7.1e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.34687 BP_3 173.27 2.49 3652 402535159 AFQ62106.1 841 7.2e-87 female-specific doublesex isoform f1 [Tribolium castaneum] 642928399 XR_511419.1 167 2.4239e-79 PREDICTED: Tribolium castaneum male-specific doublesex isoform m (LOC660453), transcript variant X2, misc_RNA K19488 DMRT1 doublesex- and mab-3-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19488 P23023 260 6.9e-21 Protein doublesex OS=Drosophila melanogaster GN=dsx PE=1 SV=1 PF01104//PF00751 Bunyavirus non-structural protein NS-s//DM DNA binding domain GO:0016032//GO:0006355 viral process//regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- KOG3815 Transcription factor Doublesex Cluster-8309.34688 BP_3 6588.27 124.47 2843 91086235 XP_966692.1 3707 0.0e+00 PREDICTED: transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum]>gi|270011017|gb|EFA07465.1| transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum] 817081112 XM_012407627.1 680 0 PREDICTED: Athalia rosae transitional endoplasmic reticulum ATPase TER94 (LOC105690094), transcript variant X2, mRNA K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q7KN62 3444 0.0e+00 Transitional endoplasmic reticulum ATPase TER94 OS=Drosophila melanogaster GN=TER94 PE=1 SV=1 PF02562//PF06414//PF02367//PF03152//PF00931//PF01057//PF00158//PF01695//PF07728//PF00004//PF01637//PF02456//PF04851//PF00005//PF03266//PF07726//PF00910//PF01443//PF05496//PF06068//PF14532//PF07724//PF00437 PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Ubiquitin fusion degradation protein UFD1//NB-ARC domain//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Adenovirus IVa2 protein//Type III restriction enzyme, res subunit//ABC transporter//NTPase//ATPase family associated with various cellular activities (AAA)//RNA helicase//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//Sigma-54 interaction domain//AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein GO:0019079//GO:0019083//GO:0006281//GO:0006810//GO:0006355//GO:0006511//GO:0006310//GO:0002949 viral genome replication//viral transcription//DNA repair//transport//regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0016787//GO:0098519//GO:0008134//GO:0016887//GO:0016301//GO:0003723//GO:0003678//GO:0003677//GO:0043531//GO:0003724//GO:0009378//GO:0017111 ATP binding//hydrolase activity//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//ATPase activity//kinase activity//RNA binding//DNA helicase activity//DNA binding//ADP binding//RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0730 AAA+-type ATPase Cluster-8309.34689 BP_3 114.00 5.71 1254 642921081 XP_975078.2 890 5.1e-93 PREDICTED: anaphase-promoting complex subunit 10 [Tribolium castaneum] -- -- -- -- -- K03357 APC10, DOC1 anaphase-promoting complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03357 Q9V831 691 2.5e-71 Anaphase-promoting complex subunit 10 OS=Drosophila melanogaster GN=APC10 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3437 Anaphase-promoting complex (APC), subunit 10 Cluster-8309.34690 BP_3 1638.65 13.23 6260 642914541 XP_008201720.1 2081 2.0e-230 PREDICTED: organic cation transporter protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 857 7.1e-90 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF04847//PF00083//PF07690 Calcipressin//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0019722 transmembrane transport//calcium-mediated signaling GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.34692 BP_3 26.27 1.63 1067 91081323 XP_970047.1 1025 9.7e-109 PREDICTED: uncharacterized oxidoreductase C115.03 [Tribolium castaneum]>gi|270005200|gb|EFA01648.1| hypothetical protein TcasGA2_TC007219 [Tribolium castaneum] -- -- -- -- -- K00010 iolG myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00010 O05389 437 6.0e-42 Uncharacterized oxidoreductase YrbE OS=Bacillus subtilis (strain 168) GN=yrbE PE=3 SV=2 PF01408//PF02894 Oxidoreductase family, NAD-binding Rossmann fold//Oxidoreductase family, C-terminal alpha/beta domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.34696 BP_3 46.66 4.37 806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34699 BP_3 343.93 6.95 2678 642925731 XP_008201510.1 470 5.5e-44 PREDICTED: snRNA-activating protein complex subunit 1-like [Tribolium castaneum]>gi|270008917|gb|EFA05365.1| hypothetical protein TcasGA2_TC015530 [Tribolium castaneum] 830186132 XM_004692871.2 69 5.32254e-25 PREDICTED: Condylura cristata vesicle-associated membrane protein 1 (synaptobrevin 1) (VAMP1), mRNA K13505 VAMP3 vesicle-associated membrane protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13505 O02495 252 4.3e-20 Synaptobrevin-1 OS=Caenorhabditis elegans GN=snb-1 PE=1 SV=1 PF00957//PF13851//PF10717 Synaptobrevin//Growth-arrest specific micro-tubule binding//Occlusion-derived virus envelope protein ODV-E18 GO:0016192//GO:0048870 vesicle-mediated transport//cell motility -- -- GO:0016021//GO:0031514//GO:0019031 integral component of membrane//motile cilium//viral envelope KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.34700 BP_3 4.97 1.50 451 546685274 ERL94801.1 401 9.3e-37 hypothetical protein D910_12075, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34701 BP_3 54.74 0.81 3542 195447626 XP_002071298.1 274 3.9e-21 GK25716 [Drosophila willistoni]>gi|194167383|gb|EDW82284.1| GK25716 [Drosophila willistoni] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 P54352 248 1.7e-19 Ethanolamine kinase OS=Drosophila melanogaster GN=eas PE=1 SV=2 -- -- GO:0006796 phosphate-containing compound metabolic process GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.34702 BP_3 196.78 11.34 1128 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34703 BP_3 737.00 28.03 1559 642925338 XP_001814375.2 1958 9.2e-217 PREDICTED: probable anion transporter 2, chloroplastic [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q652N5 604 3.8e-61 Probable anion transporter 4, chloroplastic OS=Oryza sativa subsp. japonica GN=PHT4;4 PE=2 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.34706 BP_3 24.71 1.26 1236 642924457 XP_008194306.1 1091 2.5e-116 PREDICTED: 60S ribosomal protein L4 [Tribolium castaneum]>gi|270006788|gb|EFA03236.1| hypothetical protein TcasGA2_TC013168 [Tribolium castaneum] 70909604 AM048989.1 230 7.66405e-115 Eucinetus sp. APV-2005 mRNA for ribosomal protein L4e (rpL4e gene) K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P09180 908 1.7e-96 60S ribosomal protein L4 OS=Drosophila melanogaster GN=RpL4 PE=1 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-8309.34707 BP_3 7454.71 78.36 4877 270001371 EEZ97818.1 1944 1.2e-214 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914992 XM_008192252.1 1023 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X4, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 O60506 1275 1.9e-138 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens GN=SYNCRIP PE=1 SV=2 PF00076//PF08675//PF16367//PF08777//PF00023//PF07648 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain//RNA recognition motif//RNA binding motif//Ankyrin repeat//Kazal-type serine protease inhibitor domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0005515//GO:0003723//GO:0046872//GO:0004535//GO:0003676 protein binding//RNA binding//metal ion binding//poly(A)-specific ribonuclease activity//nucleic acid binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.34708 BP_3 638.14 25.41 1502 270001371 EEZ97818.1 1186 2.9e-127 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914986 XM_008192248.1 413 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X1, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 Q7TMK9 769 2.7e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.34710 BP_3 48.08 1.42 1926 270000972 EEZ97419.1 470 4.0e-44 hypothetical protein TcasGA2_TC011249 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8AWF5 205 8.7e-15 Kinetochore protein NDC80 homolog OS=Xenopus laevis GN=ndc80 PE=1 SV=2 PF00765//PF00170//PF00700//PF03836//PF05791 Autoinducer synthase//bZIP transcription factor//Bacterial flagellin C-terminal helical region//RasGAP C-terminus//Bacillus haemolytic enterotoxin (HBL) GO:0006355//GO:0007264//GO:0009405//GO:0071973 regulation of transcription, DNA-templated//small GTPase mediated signal transduction//pathogenesis//bacterial-type flagellum-dependent cell motility GO:0043565//GO:0003700//GO:0005096//GO:0016740//GO:0005198 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//GTPase activator activity//transferase activity//structural molecule activity GO:0016020//GO:0005667 membrane//transcription factor complex -- -- Cluster-8309.34711 BP_3 324.32 1.80 8990 270003434 EEZ99881.1 5772 0.0e+00 hypothetical protein TcasGA2_TC002665 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.81589e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.6e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF00023//PF01637//PF02376//PF13414//PF13639//PF07728//PF13606//PF00004 Ankyrin repeat//Archaeal ATPase//CUT domain//TPR repeat//Ring finger domain//AAA domain (dynein-related subfamily)//Ankyrin repeat//ATPase family associated with various cellular activities (AAA) -- -- GO:0005524//GO:0008270//GO:0003677//GO:0016887//GO:0005515 ATP binding//zinc ion binding//DNA binding//ATPase activity//protein binding -- -- -- -- Cluster-8309.34712 BP_3 284.36 2.86 5082 826411269 XP_012542660.1 269 2.1e-20 PREDICTED: 23 kDa integral membrane protein-like [Monomorium pharaonis] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q26499 193 5.7e-13 23 kDa integral membrane protein OS=Schistosoma haematobium PE=2 SV=1 PF02076//PF01757//PF03600//PF04144//PF00335 Pheromone A receptor//Acyltransferase family//Citrate transporter//SCAMP family//Tetraspanin family GO:0055085//GO:0007186//GO:0007606//GO:0015031//GO:0019236 transmembrane transport//G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//protein transport//response to pheromone GO:0016747//GO:0004932 transferase activity, transferring acyl groups other than amino-acyl groups//mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.34714 BP_3 58.40 1.36 2364 478258626 ENN78676.1 1384 5.0e-150 hypothetical protein YQE_04848, partial [Dendroctonus ponderosae]>gi|546685782|gb|ERL95231.1| hypothetical protein D910_12498, partial [Dendroctonus ponderosae] 124303520 DQ872653.2 144 9.53282e-67 Carassius auratus HSP60 mRNA, complete cds K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 O02649 1205 1.2e-130 60 kDa heat shock protein, mitochondrial OS=Drosophila melanogaster GN=Hsp60 PE=1 SV=3 PF00118//PF02912 TCP-1/cpn60 chaperonin family//Aminoacyl tRNA synthetase class II, N-terminal domain GO:0006571//GO:0000162//GO:0009094//GO:0006432 tyrosine biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process//phenylalanyl-tRNA aminoacylation GO:0000166//GO:0004826//GO:0005524 nucleotide binding//phenylalanine-tRNA ligase activity//ATP binding GO:0005737//GO:0009328 cytoplasm//phenylalanine-tRNA ligase complex KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-8309.34715 BP_3 4846.76 107.74 2460 91090031 XP_967844.1 2473 2.8e-276 PREDICTED: V-type proton ATPase subunit B [Tribolium castaneum]>gi|270014269|gb|EFA10717.1| hypothetical protein TcasGA2_TC012133 [Tribolium castaneum] 9713 X64354.1 700 0 M.sexta mRNA for vacuolar ATPase subunit B K02147 ATPeV1B, ATP6B V-type H+-transporting ATPase subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02147 P31409 2463 1.6e-276 V-type proton ATPase subunit B OS=Drosophila melanogaster GN=Vha55 PE=2 SV=1 PF00306//PF00006//PF03893//PF02874 ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, nucleotide-binding domain//Lipase 3 N-terminal region//ATP synthase alpha/beta family, beta-barrel domain GO:0046034//GO:0015991//GO:0016042//GO:0015992 ATP metabolic process//ATP hydrolysis coupled proton transport//lipid catabolic process//proton transport GO:0005524//GO:0016820 ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033180//GO:0033178 proton-transporting V-type ATPase, V1 domain//proton-transporting two-sector ATPase complex, catalytic domain KOG1351 Vacuolar H+-ATPase V1 sector, subunit B Cluster-8309.34716 BP_3 379.45 6.50 3107 478257505 ENN77661.1 3265 0.0e+00 hypothetical protein YQE_05955, partial [Dendroctonus ponderosae] 195398740 XM_002057943.1 332 3.89557e-171 Drosophila virilis GJ15746 (Dvir\GJ15746), mRNA K12392 AP1B1 AP-1 complex subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12392 Q10567 1843 1.6e-204 AP-1 complex subunit beta-1 OS=Homo sapiens GN=AP1B1 PE=1 SV=2 PF02883//PF02985//PF09066//PF00514//PF08802//PF03094//PF01602 Adaptin C-terminal domain//HEAT repeat//Beta2-adaptin appendage, C-terminal sub-domain//Armadillo/beta-catenin-like repeat//Cytochrome B6-F complex Fe-S subunit//Mlo family//Adaptin N terminal region GO:0016192//GO:0006886//GO:0006952//GO:0006118//GO:0055114 vesicle-mediated transport//intracellular protein transport//defense response//obsolete electron transport//oxidation-reduction process GO:0051537//GO:0005515//GO:0009496 2 iron, 2 sulfur cluster binding//protein binding//plastoquinol--plastocyanin reductase activity GO:0009512//GO:0016021//GO:0042651//GO:0030131//GO:0030117 cytochrome b6f complex//integral component of membrane//thylakoid membrane//clathrin adaptor complex//membrane coat KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit Cluster-8309.34717 BP_3 736.51 12.82 3061 478257505 ENN77661.1 3915 0.0e+00 hypothetical protein YQE_05955, partial [Dendroctonus ponderosae] 195398740 XM_002057943.1 488 0 Drosophila virilis GJ15746 (Dvir\GJ15746), mRNA K12392 AP1B1 AP-1 complex subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12392 Q10567 2480 2.2e-278 AP-1 complex subunit beta-1 OS=Homo sapiens GN=AP1B1 PE=1 SV=2 PF02883//PF02985//PF09066//PF08802//PF01602//PF03094//PF00514 Adaptin C-terminal domain//HEAT repeat//Beta2-adaptin appendage, C-terminal sub-domain//Cytochrome B6-F complex Fe-S subunit//Adaptin N terminal region//Mlo family//Armadillo/beta-catenin-like repeat GO:0006118//GO:0055114//GO:0016192//GO:0006886//GO:0006952 obsolete electron transport//oxidation-reduction process//vesicle-mediated transport//intracellular protein transport//defense response GO:0009496//GO:0051537//GO:0005515 plastoquinol--plastocyanin reductase activity//2 iron, 2 sulfur cluster binding//protein binding GO:0030117//GO:0009512//GO:0016021//GO:0042651//GO:0030131 membrane coat//cytochrome b6f complex//integral component of membrane//thylakoid membrane//clathrin adaptor complex KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit Cluster-8309.34718 BP_3 10027.01 1006.29 772 91081145 XP_975558.1 993 3.6e-105 PREDICTED: 60S ribosomal protein L10a isoform X2 [Tribolium castaneum]>gi|270005283|gb|EFA01731.1| hypothetical protein TcasGA2_TC007324 [Tribolium castaneum] 264667338 GU120405.1 269 9.843e-137 Chrysomela tremulae ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 921 3.3e-98 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG1570 60S ribosomal protein L10A Cluster-8309.34719 BP_3 37.53 0.96 2181 283046732 NP_001164313.1 1426 6.3e-155 peroxidase precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 2.2e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.34720 BP_3 16.31 0.42 2179 283046732 NP_001164313.1 1439 1.9e-156 peroxidase precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 2.2e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.34723 BP_3 28.74 2.26 905 642926225 XP_008194836.1 498 1.1e-47 PREDICTED: 60S ribosomal protein L22 [Tribolium castaneum]>gi|270009023|gb|EFA05471.1| hypothetical protein TcasGA2_TC015654 [Tribolium castaneum] 762137041 XM_011453508.1 50 6.40499e-15 PREDICTED: Crassostrea gigas 60S ribosomal protein L22-like (LOC105345379), mRNA K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 309 3.6e-27 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG3434 60S ribosomal protein L22 Cluster-8309.34726 BP_3 1485.85 216.16 623 478250208 ENN70711.1 561 3.6e-55 hypothetical protein YQE_12656, partial [Dendroctonus ponderosae]>gi|546683976|gb|ERL93710.1| hypothetical protein D910_10997 [Dendroctonus ponderosae] 805772113 XM_003701659.2 54 2.58838e-17 PREDICTED: Megachile rotundata protein lethal(2)essential for life-like (LOC100881460), mRNA K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 430 2.3e-41 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF04209//PF00525 homogentisate 1,2-dioxygenase//Alpha crystallin A chain, N terminal GO:0007423//GO:0055114//GO:0042207//GO:0006570//GO:0006559 sensory organ development//oxidation-reduction process//styrene catabolic process//tyrosine metabolic process//L-phenylalanine catabolic process GO:0005212//GO:0004411 structural constituent of eye lens//homogentisate 1,2-dioxygenase activity -- -- -- -- Cluster-8309.34728 BP_3 67.70 1.61 2317 270015207 EFA11655.1 1075 3.3e-114 hypothetical protein TcasGA2_TC004080 [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 A6QNP3 340 2.3e-30 Protein phosphatase 1 regulatory subunit 3B OS=Bos taurus GN=PPP1R3B PE=2 SV=1 PF03370//PF16760 Carbohydrate/starch-binding module (family 21)//Starch/carbohydrate-binding module (family 53) -- -- GO:2001070//GO:0005515 starch binding//protein binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.34729 BP_3 508.00 43.63 853 91089531 XP_966781.1 777 4.4e-80 PREDICTED: protein BUD31 homolog [Tribolium castaneum]>gi|270011373|gb|EFA07821.1| hypothetical protein TcasGA2_TC005390 [Tribolium castaneum] 665805374 XM_008552656.1 137 2.61066e-63 PREDICTED: Microplitis demolitor protein BUD31 homolog (LOC103573515), mRNA K12873 BUD31, G10 bud site selection protein 31 http://www.genome.jp/dbget-bin/www_bget?ko:K12873 Q962X9 754 8.4e-79 Protein BUD31 homolog OS=Branchiostoma belcheri PE=2 SV=1 PF01125 G10 protein -- -- -- -- GO:0005634 nucleus KOG3404 G10 protein/predicted nuclear transcription regulator Cluster-8309.34731 BP_3 601.08 37.37 1067 546674972 ERL86242.1 595 7.0e-59 hypothetical protein D910_03652 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZBE7 522 8.4e-52 Protein yippee-like 5 OS=Bos taurus GN=YPEL5 PE=2 SV=1 PF07127//PF01641//PF11648 Late nodulin protein//SelR domain//C-terminal domain of RIG-I GO:0009878//GO:0055114 nodule morphogenesis//oxidation-reduction process GO:0033743//GO:0016817//GO:0046872 peptide-methionine (R)-S-oxide reductase activity//hydrolase activity, acting on acid anhydrides//metal ion binding -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.34732 BP_3 3.01 0.54 559 91093173 XP_967937.1 309 5.4e-26 PREDICTED: 40S ribosomal protein S21 [Tribolium castaneum]>gi|270012942|gb|EFA09390.1| hypothetical protein TcasGA2_TC004308 [Tribolium castaneum] -- -- -- -- -- K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q4GXP2 301 1.9e-26 40S ribosomal protein S21 OS=Biphyllus lunatus GN=RpS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-8309.34734 BP_3 1146.72 101.18 838 91091114 XP_966512.1 833 1.4e-86 PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|91091116|ref|XP_975893.1| PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|270014090|gb|EFA10538.1| hypothetical protein TcasGA2_TC012793 [Tribolium castaneum] 768428971 XM_011557345.1 188 1.14282e-91 PREDICTED: Plutella xylostella GTP-binding nuclear protein Ran (LOC105386728), mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 Q9VZ23 810 2.7e-85 GTP-binding nuclear protein Ran OS=Drosophila melanogaster GN=ran PE=1 SV=1 PF00071//PF04670//PF00910//PF00503//PF02367//PF03193//PF00025//PF01926//PF08477 Ras family//Gtr1/RagA G protein conserved region//RNA helicase//G-protein alpha subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0002949//GO:0006184//GO:0007264//GO:0007165//GO:0006913//GO:0006886 G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification//obsolete GTP catabolic process//small GTPase mediated signal transduction//signal transduction//nucleocytoplasmic transport//intracellular protein transport GO:0005525//GO:0019001//GO:0004871//GO:0003724//GO:0003723//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//RNA helicase activity//RNA binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0005622 intracellular KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-8309.34735 BP_3 86.00 18.89 511 642938415 XP_008199791.1 291 6.0e-24 PREDICTED: coleoptericin-like [Tribolium castaneum]>gi|270015418|gb|EFA11866.1| hypothetical protein TcasGA2_TC005093 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81592 458 1.1e-44 Acaloleptin A OS=Acalolepta luxuriosa PE=1 SV=2 PF06286 Coleoptericin GO:0042742 defense response to bacterium -- -- GO:0005576 extracellular region -- -- Cluster-8309.34736 BP_3 651.00 22.49 1687 674304048 AIL23555.1 425 5.7e-39 microsomal glutathione S-transferase [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8HZJ2 174 3.0e-11 Prostaglandin E synthase OS=Equus caballus GN=PTGES PE=2 SV=1 PF02109 DAD family GO:0018279 protein N-linked glycosylation via asparagine GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0008250//GO:0016021 oligosaccharyltransferase complex//integral component of membrane -- -- Cluster-8309.34737 BP_3 2131.44 76.03 1643 728418241 AIY68362.1 976 7.2e-103 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 485 2.5e-47 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.34740 BP_3 2006.71 19.31 5300 642935129 XP_008197899.1 458 2.7e-42 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- K14651 TAF15, NPL3 transcription initiation factor TFIID subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14651 Q27294 374 6.1e-34 RNA-binding protein cabeza OS=Drosophila melanogaster GN=caz PE=2 SV=2 PF00076//PF00641 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zn-finger in Ran binding protein and others -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG1995 Conserved Zn-finger protein Cluster-8309.34741 BP_3 84.87 0.34 12498 270013018 EFA09466.1 6307 0.0e+00 hypothetical protein TcasGA2_TC010960 [Tribolium castaneum] 168029506 XM_001767215.1 50 9.1547e-14 Physcomitrella patens subsp. patens predicted protein (PHYPADRAFT_131838) mRNA, complete cds K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8WXX0 4321 0.0e+00 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 PF00158//PF07728//PF01695//PF07724//PF03028//PF00004//PF00437//PF04851//PF01637//PF00580//PF05418//PF02601//PF00910 Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//Dynein heavy chain and region D6 of dynein motor//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Type III restriction enzyme, res subunit//Archaeal ATPase//UvrD/REP helicase N-terminal domain//Apovitellenin I (Apo-VLDL-II)//Exonuclease VII, large subunit//RNA helicase GO:0006629//GO:0006308//GO:0007018//GO:0006810//GO:0006355//GO:0007017 lipid metabolic process//DNA catabolic process//microtubule-based movement//transport//regulation of transcription, DNA-templated//microtubule-based process GO:0003723//GO:0003677//GO:0008855//GO:0004857//GO:0003777//GO:0003724//GO:0005524//GO:0016787//GO:0008134//GO:0016887 RNA binding//DNA binding//exodeoxyribonuclease VII activity//enzyme inhibitor activity//microtubule motor activity//RNA helicase activity//ATP binding//hydrolase activity//transcription factor binding//ATPase activity GO:0030286//GO:0005874//GO:0005667//GO:0009318//GO:0042627 dynein complex//microtubule//transcription factor complex//exodeoxyribonuclease VII complex//chylomicron -- -- Cluster-8309.34742 BP_3 910.21 12.12 3911 642934648 XP_972393.2 1463 5.8e-159 PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934650|ref|XP_008197751.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934652|ref|XP_008197752.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10463 KLHL26 kelch-like protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K10463 Q8BGY4 392 3.7e-36 Kelch-like protein 26 OS=Mus musculus GN=Klhl26 PE=2 SV=1 PF00651//PF07646//PF01344 BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34743 BP_3 966.50 14.68 3464 91080681 XP_975202.1 1354 2.2e-146 PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|642919555|ref|XP_008191921.1| PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|270005851|gb|EFA02299.1| hypothetical protein TcasGA2_TC007964 [Tribolium castaneum] 665800505 XM_008549999.1 212 2.21802e-104 PREDICTED: Microplitis demolitor CCR4-NOT transcription complex subunit 7 (LOC103571729), transcript variant X3, mRNA K12581 CNOT7_8, CAF1, POP2 CCR4-NOT transcription complex subunit 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12581 Q9UIV1 1046 4.7e-112 CCR4-NOT transcription complex subunit 7 OS=Homo sapiens GN=CNOT7 PE=1 SV=3 PF04857//PF13482 CAF1 family ribonuclease//RNase_H superfamily -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG0304 mRNA deadenylase subunit Cluster-8309.34744 BP_3 453.00 12.24 2075 91093669 XP_969370.1 1982 2.0e-219 PREDICTED: phosphatidylserine synthase 1 [Tribolium castaneum]>gi|270008072|gb|EFA04520.1| hypothetical protein TcasGA2_TC016315 [Tribolium castaneum] 755857845 XM_011298312.1 116 3.06758e-51 PREDICTED: Musca domestica phosphatidylserine synthase 1 (LOC101896380), transcript variant X3, mRNA K08729 PTDSS1 phosphatidylserine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08729 Q5ZM65 1307 1.5e-142 Phosphatidylserine synthase 1 OS=Gallus gallus GN=PTDSS1 PE=2 SV=2 PF03034//PF01371 Phosphatidyl serine synthase//Trp repressor protein GO:0006355//GO:0006659 regulation of transcription, DNA-templated//phosphatidylserine biosynthetic process GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG2735 Phosphatidylserine synthase Cluster-8309.34745 BP_3 322.99 8.07 2222 546682142 ERL92123.1 1937 3.6e-214 hypothetical protein D910_09443 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NFD2 274 1.0e-22 Ankyrin repeat and protein kinase domain-containing protein 1 OS=Homo sapiens GN=ANKK1 PE=2 SV=1 PF13606//PF00023//PF11616//PF07525 Ankyrin repeat//Ankyrin repeat//WD repeat binding protein EZH2//SOCS box GO:0006554//GO:0035556//GO:0006479 lysine catabolic process//intracellular signal transduction//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG4177 Ankyrin Cluster-8309.34746 BP_3 2629.49 658.38 484 727098952 AIY54301.1 682 2.6e-69 ribosomal protein L32e [Colaphellus bowringi] 727098951 KJ534560.1 204 8.17871e-101 Colaphellus bowringi ribosomal protein L32e (RPL32e) mRNA, complete cds K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q8WRF3 637 1.8e-65 60S ribosomal protein L32 OS=Apis mellifera GN=RpL32 PE=2 SV=1 PF01655 Ribosomal protein L32 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0878 60S ribosomal protein L32 Cluster-8309.34747 BP_3 390.33 1.55 12451 642937614 XP_008199122.1 15377 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 792 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 O95714 5609 0.0e+00 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2 PF06701//PF02898//PF07236//PF00569 Mib_herc2//Nitric oxide synthase, oxygenase domain//Phytoreovirus S7 protein//Zinc finger, ZZ type GO:0055114//GO:0006809//GO:0016567 oxidation-reduction process//nitric oxide biosynthetic process//protein ubiquitination GO:0008270//GO:0046872//GO:0004517//GO:0004842 zinc ion binding//metal ion binding//nitric-oxide synthase activity//ubiquitin-protein transferase activity GO:0019012 virion KOG1426 FOG: RCC1 domain Cluster-8309.3475 BP_3 5.00 0.55 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34750 BP_3 2549.00 116.32 1348 148469568 ABQ65713.1 181 9.0e-11 encapsulation-relating protein variant a [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06391 CDK-activating kinase assembly factor MAT1 GO:0007049 cell cycle -- -- GO:0005634 nucleus -- -- Cluster-8309.34754 BP_3 273.00 13.26 1284 270013885 EFA10333.1 858 2.7e-89 hypothetical protein TcasGA2_TC012551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4LDE5 185 1.2e-12 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens GN=SVEP1 PE=1 SV=3 PF05001//PF07271 RNA polymerase Rpb1 C-terminal repeat//Cytadhesin P30/P32 GO:0009405//GO:0006366//GO:0007157 pathogenesis//transcription from RNA polymerase II promoter//heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0003677 DNA binding GO:0016021//GO:0005665 integral component of membrane//DNA-directed RNA polymerase II, core complex -- -- Cluster-8309.34757 BP_3 2571.58 57.70 2440 91081923 XP_970724.1 1566 4.1e-171 PREDICTED: dnaJ homolog subfamily A member 2 [Tribolium castaneum]>gi|270007352|gb|EFA03800.1| hypothetical protein TcasGA2_TC013913 [Tribolium castaneum] 642921669 XM_965631.3 188 3.41745e-91 PREDICTED: Tribolium castaneum dnaJ homolog subfamily A member 2 (LOC659314), mRNA K09503 DNAJA2 DnaJ homolog subfamily A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09503 O60884 1192 3.9e-129 DnaJ homolog subfamily A member 2 OS=Homo sapiens GN=DNAJA2 PE=1 SV=1 PF00684//PF01155//PF11023 DnaJ central domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-ribbon containing domain GO:0006260//GO:0009408//GO:0006457//GO:0006464 DNA replication//response to heat//protein folding//cellular protein modification process GO:0046872//GO:0051082//GO:0016151//GO:0031072//GO:0005524 metal ion binding//unfolded protein binding//nickel cation binding//heat shock protein binding//ATP binding GO:0005737//GO:0005887 cytoplasm//integral component of plasma membrane KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.34758 BP_3 348.81 46.53 653 282721116 NP_001164230.1 530 1.5e-51 mitochondrial acyl carrier protein 1 isoform B [Tribolium castaneum]>gi|270012710|gb|EFA09158.1| mitochondrial acyl carrier protein 1 isoform A [Tribolium castaneum] -- -- -- -- -- K03955 NDUFAB1 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03955 Q94519 311 1.5e-27 Acyl carrier protein, mitochondrial OS=Drosophila melanogaster GN=mtacp1 PE=2 SV=1 -- -- GO:0006633 fatty acid biosynthetic process -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-8309.34759 BP_3 1192.73 141.85 697 270011246 EFA07694.1 449 3.9e-42 hypothetical protein TcasGA2_TC030783 [Tribolium castaneum] 642929327 XM_968543.2 196 3.36559e-96 PREDICTED: Tribolium castaneum protein krasavietz (LOC662449), mRNA -- -- -- -- Q9VNE2 351 3.7e-32 Protein krasavietz OS=Drosophila melanogaster GN=kra PE=1 SV=1 PF16782//PF02020 Nucleotide exchange factor SIL1//eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515//GO:0000774 protein binding//adenyl-nucleotide exchange factor activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.34760 BP_3 10521.89 114.21 4732 91094123 XP_968324.1 1235 1.9e-132 PREDICTED: zinc transporter 7 [Tribolium castaneum] 213521413 FJ430679.1 90 2.00483e-36 Lutzomyia shannoni clone LZ-A35 small ribosomal subunit S25 mRNA, complete cds K14692 SLC30A5_7, ZNT5_7, MTP, MSC2 solute carrier family 30 (zinc transporter), member 5/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14692 Q52KD7 474 1.4e-45 Zinc transporter 7-A OS=Xenopus laevis GN=slc30a7-a PE=2 SV=1 PF09302//PF06632//PF01325//PF01545 XLF-Cernunnos, XRcc4-like factor, NHEJ component//DNA double-strand break repair and V(D)J recombination protein XRCC4//Iron dependent repressor, N-terminal DNA binding domain//Cation efflux family GO:0006302//GO:0006812//GO:0006310//GO:0055085 double-strand break repair//cation transport//DNA recombination//transmembrane transport GO:0008324//GO:0003677 cation transmembrane transporter activity//DNA binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion facilitator superfamily) Cluster-8309.34761 BP_3 72.86 2.93 1491 546682999 ERL92871.1 322 4.4e-27 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C8U0 170 7.7e-11 Liprin-beta-1 OS=Mus musculus GN=Ppfibp1 PE=1 SV=3 PF02601//PF01763//PF04111 Exonuclease VII, large subunit//Herpesvirus UL6 like//Autophagy protein Apg6 GO:0006308//GO:0006914//GO:0006323 DNA catabolic process//autophagy//DNA packaging GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG1899 LAR transmembrane tyrosine phosphatase-interacting protein liprin Cluster-8309.34762 BP_3 1434.49 10.00 7205 642920483 XP_008192370.1 2835 0.0e+00 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K03680 EIF2B4 translation initiation factor eIF-2B subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K03680 Q63186 925 1.1e-97 Translation initiation factor eIF-2B subunit delta OS=Rattus norvegicus GN=Eif2b4 PE=2 SV=1 PF01008//PF01763//PF02198//PF00536//PF07647//PF01496//PF02601 Initiation factor 2 subunit family//Herpesvirus UL6 like//Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//V-type ATPase 116kDa subunit family//Exonuclease VII, large subunit GO:0015991//GO:0044237//GO:0006323//GO:0015992//GO:0006308 ATP hydrolysis coupled proton transport//cellular metabolic process//DNA packaging//proton transport//DNA catabolic process GO:0008855//GO:0005515//GO:0043565//GO:0015078 exodeoxyribonuclease VII activity//protein binding//sequence-specific DNA binding//hydrogen ion transmembrane transporter activity GO:0005634//GO:0033179//GO:0009318 nucleus//proton-transporting V-type ATPase, V0 domain//exodeoxyribonuclease VII complex KOG1467 Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2) Cluster-8309.34763 BP_3 295.25 13.27 1364 546682999 ERL92871.1 737 3.1e-75 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34764 BP_3 5.75 0.51 830 167444204 ABZ80663.1 326 8.5e-28 hypothetical antimicrobial peptide [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.34765 BP_3 473.69 3.93 6097 646718907 KDR21210.1 2675 2.6e-299 Calcium-transporting ATPase type 2C member 1 [Zootermopsis nevadensis] 701357390 XM_010007485.1 90 2.58758e-36 PREDICTED: Chaetura pelagica ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), mRNA K01537 E3.6.3.8 Ca2+-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01537 P57709 2088 1.2e-232 Calcium-transporting ATPase type 2C member 1 OS=Bos taurus GN=ATP2C1 PE=2 SV=1 PF06450//PF13912//PF16622//PF00122//PF00096 Bacterial Na+/H+ antiporter B (NhaB)//C2H2-type zinc finger//zinc-finger C2H2-type//E1-E2 ATPase//Zinc finger, C2H2 type GO:0015992//GO:0006814//GO:0006885 proton transport//sodium ion transport//regulation of pH GO:0046872//GO:0015385//GO:0000166 metal ion binding//sodium:proton antiporter activity//nucleotide binding GO:0016021 integral component of membrane KOG0202 Ca2+ transporting ATPase Cluster-8309.34768 BP_3 174.00 9.79 1148 189239759 XP_001807559.1 534 8.9e-52 PREDICTED: transcription factor MafK [Tribolium castaneum]>gi|270012669|gb|EFA09117.1| hypothetical protein TcasGA2_TC015977 [Tribolium castaneum] -- -- -- -- -- K09037 MAFF_G_K transcription factor MAFF/G/K http://www.genome.jp/dbget-bin/www_bget?ko:K09037 O60675 274 5.2e-23 Transcription factor MafK OS=Homo sapiens GN=MAFK PE=1 SV=1 PF04111//PF03131//PF00170//PF03404 Autophagy protein Apg6//bZIP Maf transcription factor//bZIP transcription factor//Mo-co oxidoreductase dimerisation domain GO:0006914//GO:0006355//GO:0055114 autophagy//regulation of transcription, DNA-templated//oxidation-reduction process GO:0003677//GO:0016491//GO:0030151//GO:0043565//GO:0003700 DNA binding//oxidoreductase activity//molybdenum ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.34770 BP_3 450.78 7.31 3265 478256311 ENN76501.1 492 1.9e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34772 BP_3 7.65 1.20 599 332373738 AEE62010.1 511 2.2e-49 unknown [Dendroctonus ponderosae]>gi|478251939|gb|ENN72377.1| hypothetical protein YQE_11012, partial [Dendroctonus ponderosae]>gi|546673071|gb|ERL84744.1| hypothetical protein D910_02169 [Dendroctonus ponderosae] -- -- -- -- -- K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P46223 428 3.7e-41 60S ribosomal protein L7a OS=Drosophila melanogaster GN=RpL7A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8309.34774 BP_3 130.16 1.84 3699 91085981 XP_971976.1 3595 0.0e+00 PREDICTED: cullin-1 [Tribolium castaneum]>gi|642927556|ref|XP_008195314.1| PREDICTED: cullin-1 [Tribolium castaneum] -- -- -- -- -- K03347 CUL1, CDC53 cullin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03347 Q9WTX6 3029 0.0e+00 Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1 PF03965//PF00888 Penicillinase repressor//Cullin family GO:0045892//GO:0006511 negative regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process GO:0031625//GO:0003677 ubiquitin protein ligase binding//DNA binding -- -- KOG2166 Cullins Cluster-8309.34775 BP_3 662.00 15.53 2346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34776 BP_3 83.07 0.69 6069 546674425 ERL85803.1 1221 1.0e-130 hypothetical protein D910_03219, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34777 BP_3 30.54 0.56 2941 478252250 ENN72678.1 169 4.8e-09 hypothetical protein YQE_10776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34779 BP_3 219.70 15.94 956 730049052 AIZ08896.1 464 9.7e-44 takeout, partial [Locusta migratoria] -- -- -- -- -- -- -- -- -- Q9VBV3 236 1.1e-18 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34782 BP_3 14609.06 515.38 1658 55978158 AAV68692.1 1713 2.5e-188 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q2PQM7 1163 6.1e-126 Chitinase-like protein Idgf4 OS=Glossina morsitans morsitans GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.34783 BP_3 1949.90 51.13 2130 645020577 XP_001608013.2 409 5.2e-37 PREDICTED: uncharacterized protein LOC100123516 isoform X2 [Nasonia vitripennis] 749773869 XM_011143970.1 77 1.50776e-29 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X2, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.34788 BP_3 1104.57 22.60 2647 642920332 XP_975626.2 1689 2.4e-185 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] 195397078 XM_002057120.1 100 3.07957e-42 Drosophila virilis GJ16936 (Dvir\GJ16936), mRNA -- -- -- -- Q6TYB5 554 4.1e-55 Fasciculation and elongation protein zeta-2 OS=Mus musculus GN=Fez2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.34789 BP_3 1877.00 465.16 486 751464756 XP_011187336.1 495 1.3e-47 PREDICTED: putative ATP synthase subunit f, mitochondrial [Bactrocera cucurbitae] -- -- -- -- -- K02130 ATPeF0F, ATP5J2 F-type H+-transporting ATPase subunit f http://www.genome.jp/dbget-bin/www_bget?ko:K02130 Q9W141 476 8.2e-47 Putative ATP synthase subunit f, mitochondrial OS=Drosophila melanogaster GN=CG4692 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4092 Mitochondrial F1F0-ATP synthase, subunit f Cluster-8309.3479 BP_3 13.00 1.48 715 270017036 EFA13482.1 235 2.6e-17 hypothetical protein TcasGA2_TC002033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34791 BP_3 904.79 14.21 3361 91088019 XP_974107.1 390 1.3e-34 PREDICTED: transcription factor A, mitochondrial [Tribolium castaneum]>gi|270012067|gb|EFA08515.1| hypothetical protein TcasGA2_TC006168 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4H0T5 227 4.3e-17 Transcription factor A, mitochondrial OS=Trachypithecus cristatus GN=TFAM PE=2 SV=1 PF05369//PF03612//PF04690 Monomethylamine methyltransferase MtmB//Sorbitol phosphotransferase enzyme II N-terminus//YABBY protein GO:0032259//GO:0008643//GO:0009401//GO:0007275 methylation//carbohydrate transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//multicellular organismal development GO:0008168//GO:0008982 methyltransferase activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357//GO:0016021 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.34793 BP_3 292.39 4.15 3688 665816435 XP_008556934.1 2575 6.2e-288 PREDICTED: cartilage oligomeric matrix protein [Microplitis demolitor] -- -- -- -- -- K04659 THBS2S thrombospondin 2/3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04659 P49747 1741 1.3e-192 Cartilage oligomeric matrix protein OS=Homo sapiens GN=COMP PE=1 SV=2 PF02412//PF05735//PF07645//PF00008//PF03327 Thrombospondin type 3 repeat//Thrombospondin C-terminal region//Calcium-binding EGF domain//EGF-like domain//Herpesvirus capsid shell protein VP19C GO:0007155//GO:0019069 cell adhesion//viral capsid assembly GO:0003677//GO:0005509//GO:0005515 DNA binding//calcium ion binding//protein binding GO:0005576 extracellular region KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.34797 BP_3 621.82 26.78 1411 91088325 XP_970263.1 1720 3.3e-189 PREDICTED: GTP-binding protein 128up [Tribolium castaneum]>gi|270011791|gb|EFA08239.1| hypothetical protein TcasGA2_TC005867 [Tribolium castaneum] 527259203 XM_005147801.1 223 6.83616e-111 PREDICTED: Melopsittacus undulatus developmentally regulated GTP binding protein 1 (LOC101878172), mRNA -- -- -- -- P32234 1604 3.8e-177 GTP-binding protein 128up OS=Drosophila melanogaster GN=128up PE=2 SV=2 PF02421//PF01926 Ferrous iron transport protein B//50S ribosome-binding GTPase GO:0015684 ferrous iron transport GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG1487 GTP-binding protein DRG1 (ODN superfamily) Cluster-8309.34799 BP_3 295.50 6.44 2502 91095137 XP_972151.1 803 1.3e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.1098e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.4e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.348 BP_3 15.00 0.47 1816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34800 BP_3 756.87 16.39 2517 642916311 XP_008190969.1 767 1.9e-78 PREDICTED: nurim homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q296J9 414 6.6e-39 Nurim homolog OS=Drosophila pseudoobscura pseudoobscura GN=nrm PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34801 BP_3 36.13 0.79 2498 642916311 XP_008190969.1 708 1.3e-71 PREDICTED: nurim homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q296J9 401 2.1e-37 Nurim homolog OS=Drosophila pseudoobscura pseudoobscura GN=nrm PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34802 BP_3 3924.78 76.42 2767 642930232 XP_008196309.1 2918 0.0e+00 PREDICTED: unc-112-related protein-like isoform X1 [Tribolium castaneum]>gi|270010684|gb|EFA07132.1| hypothetical protein TcasGA2_TC010123 [Tribolium castaneum] -- -- -- -- -- K17083 FERMT2, KIND2 kindlin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17083 Q9VZI3 2148 6.2e-240 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 -- -- -- -- GO:0005543 phospholipid binding -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.34803 BP_3 10.00 0.96 795 642930232 XP_008196309.1 366 1.9e-32 PREDICTED: unc-112-related protein-like isoform X1 [Tribolium castaneum]>gi|270010684|gb|EFA07132.1| hypothetical protein TcasGA2_TC010123 [Tribolium castaneum] -- -- -- -- -- K17082 FERMT1, KIND1 kindlin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17082 Q9VZI3 315 6.3e-28 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 -- -- -- -- GO:0005543 phospholipid binding -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.34804 BP_3 8.99 0.47 1217 91078694 XP_971269.1 963 1.7e-101 PREDICTED: mitochondrial inner membrane protease ATP23 homolog [Tribolium castaneum]>gi|270003760|gb|EFA00208.1| hypothetical protein TcasGA2_TC003033 [Tribolium castaneum] -- -- -- -- -- K18156 ATP23, XRCC6BP1 mitochondrial inner membrane protease ATP23 http://www.genome.jp/dbget-bin/www_bget?ko:K18156 A4IGF3 406 2.7e-38 Mitochondrial inner membrane protease ATP23 homolog OS=Danio rerio GN=zgc:162885 PE=2 SV=1 PF09044//PF09768 Kp4//Peptidase M76 family GO:0009405 pathogenesis GO:0004222 metalloendopeptidase activity GO:0005576 extracellular region KOG3314 Ku70-binding protein Cluster-8309.34807 BP_3 1767.67 37.41 2569 91080939 XP_974274.1 791 3.2e-81 PREDICTED: signal peptidase complex subunit 3 [Tribolium castaneum]>gi|270005949|gb|EFA02397.1| hypothetical protein TcasGA2_TC008077 [Tribolium castaneum] -- -- -- -- -- K12948 SPCS3, SPC3 signal peptidase complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12948 Q9VCA9 701 3.6e-72 Signal peptidase complex subunit 3 OS=Drosophila melanogaster GN=Spase22-23 PE=2 SV=1 PF03493//PF03468//PF07544//PF02372//PF02601//PF04573//PF08519 Calcium-activated BK potassium channel alpha subunit//XS domain//RNA polymerase II transcription mediator complex subunit 9//Interleukin 15//Exonuclease VII, large subunit//Signal peptidase subunit//Replication factor RFC1 C terminal domain GO:0006955//GO:0006260//GO:0006357//GO:0031047//GO:0007165//GO:0006308//GO:0006465//GO:0006813 immune response//DNA replication//regulation of transcription from RNA polymerase II promoter//gene silencing by RNA//signal transduction//DNA catabolic process//signal peptide processing//potassium ion transport GO:0003689//GO:0005126//GO:0008233//GO:0005524//GO:0015269//GO:0001104//GO:0008855 DNA clamp loader activity//cytokine receptor binding//peptidase activity//ATP binding//calcium-activated potassium channel activity//RNA polymerase II transcription cofactor activity//exodeoxyribonuclease VII activity GO:0009318//GO:0005787//GO:0016021//GO:0042575//GO:0005663//GO:0016020//GO:0005576//GO:0016592 exodeoxyribonuclease VII complex//signal peptidase complex//integral component of membrane//DNA polymerase complex//DNA replication factor C complex//membrane//extracellular region//mediator complex KOG3372 Signal peptidase complex subunit Cluster-8309.34810 BP_3 323.69 12.88 1503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04210 Tetrahydromethanopterin S-methyltransferase, subunit G GO:0015948//GO:0046656 methanogenesis//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.34812 BP_3 685.44 7.21 4873 91085983 XP_972029.1 1888 3.8e-208 PREDICTED: TBC1 domain family member 31 [Tribolium castaneum]>gi|270010179|gb|EFA06627.1| hypothetical protein TcasGA2_TC009546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DN5 1045 8.7e-112 TBC1 domain family member 31 OS=Homo sapiens GN=TBC1D31 PE=2 SV=2 PF00156//PF03091//PF06689//PF03310 Phosphoribosyl transferase domain//CutA1 divalent ion tolerance protein//ClpX C4-type zinc finger//Caulimovirus DNA-binding protein GO:0010038//GO:0009116 response to metal ion//nucleoside metabolic process GO:0008270//GO:0003677//GO:0046983 zinc ion binding//DNA binding//protein dimerization activity -- -- KOG1712 Adenine phosphoribosyl transferases Cluster-8309.34813 BP_3 292.32 5.25 2977 642917564 XP_008191258.1 2874 0.0e+00 PREDICTED: NF-X1-type zinc finger protein NFXL1 [Tribolium castaneum] -- -- -- -- -- K15683 NFXL1, OZFP NF-X1-type zinc finger protein NFXL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15683 Q6ZNB6 1845 9.1e-205 NF-X1-type zinc finger protein NFXL1 OS=Homo sapiens GN=NFXL1 PE=1 SV=2 PF01422//PF08771 NF-X1 type zinc finger//Rapamycin binding domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003700//GO:0008144 zinc ion binding//transcription factor activity, sequence-specific DNA binding//drug binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.34814 BP_3 72.65 1.50 2632 270004742 EFA01190.1 2045 1.3e-226 hypothetical protein TcasGA2_TC010516 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 1586 8.7e-175 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006090//GO:0071436//GO:0006814//GO:0006525//GO:0006560 pyruvate metabolic process//sodium ion export//sodium ion transport//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane KOG3097 Predicted membrane protein Cluster-8309.34815 BP_3 695.85 27.71 1502 642922684 XP_008193279.1 497 2.3e-47 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X11 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 224 4.3e-17 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF00057//PF10717 Low-density lipoprotein receptor domain class A//Occlusion-derived virus envelope protein ODV-E18 -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.34816 BP_3 150.56 5.84 1535 642922680 XP_008193277.1 347 5.8e-30 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X9 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 224 4.4e-17 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF00057//PF10717 Low-density lipoprotein receptor domain class A//Occlusion-derived virus envelope protein ODV-E18 -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.34819 BP_3 14525.57 413.96 1983 642920402 XP_008192333.1 471 3.1e-44 PREDICTED: uncharacterized protein LOC664268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34820 BP_3 3797.67 214.78 1144 91090754 XP_968387.1 801 9.8e-83 PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935819|ref|XP_008198188.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935821|ref|XP_008198189.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|270013960|gb|EFA10408.1| hypothetical protein TcasGA2_TC012647 [Tribolium castaneum] 642935820 XM_008199967.1 264 8.91003e-134 PREDICTED: Tribolium castaneum ADP-ribosylation factor 1 (LOC656788), transcript variant X3, mRNA K07937 ARF1 ADP-ribosylation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07937 P61209 794 2.6e-83 ADP-ribosylation factor 1 OS=Drosophila melanogaster GN=Arf79F PE=2 SV=2 PF01926//PF08477//PF04670//PF00025//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//G-protein alpha subunit GO:0007264//GO:0007186//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0003924//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//GTPase activity//G-protein beta/gamma-subunit complex binding GO:0005622 intracellular KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.34823 BP_3 56.00 1.01 2952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06662 D-glucuronyl C5-epimerase C-terminus GO:0006024 glycosaminoglycan biosynthetic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016021 integral component of membrane -- -- Cluster-8309.34825 BP_3 33.50 4.89 622 546683491 ERL93297.1 202 1.5e-13 hypothetical protein D910_10592 [Dendroctonus ponderosae] 642939025 XR_511766.1 46 7.23545e-13 PREDICTED: Tribolium castaneum ATP-dependent RNA helicase p62 (Rm62), transcript variant X2, misc_RNA K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 A5A6J2 178 3.8e-12 Probable ATP-dependent RNA helicase DDX5 OS=Pan troglodytes GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.34826 BP_3 33.50 4.89 622 546683491 ERL93297.1 202 1.5e-13 hypothetical protein D910_10592 [Dendroctonus ponderosae] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 A5A6J2 178 3.8e-12 Probable ATP-dependent RNA helicase DDX5 OS=Pan troglodytes GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.34827 BP_3 758.95 8.03 4846 642916747 XP_972619.2 2490 5.8e-278 PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916749|ref|XP_008192467.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916751|ref|XP_008192470.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04422 MAP3K13, LZK mitogen-activated protein kinase kinase kinase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K04422 Q12852 1037 7.3e-111 Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens GN=MAP3K12 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG4721 Serine/threonine protein kinase, contains leucine zipper domain Cluster-8309.34830 BP_3 323.05 2.72 6008 642911450 XP_973171.3 2535 4.4e-283 PREDICTED: cullin-associated NEDD8-dissociated protein 1 [Tribolium castaneum]>gi|270014883|gb|EFA11331.1| hypothetical protein TcasGA2_TC010870 [Tribolium castaneum] -- -- -- -- -- K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 2076 3.0e-231 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985//PF08064//PF07571//PF11698//PF01602//PF00443//PF07062//PF00790 HEAT repeat//UME (NUC010) domain//TAF6 C-terminal HEAT repeat domain//V-ATPase subunit H//Adaptin N terminal region//Ubiquitin carboxyl-terminal hydrolase//Clc-like//VHS domain GO:0016192//GO:0016310//GO:0051090//GO:0015991//GO:0006886//GO:0009069//GO:0016579 vesicle-mediated transport//phosphorylation//regulation of sequence-specific DNA binding transcription factor activity//ATP hydrolysis coupled proton transport//intracellular protein transport//serine family amino acid metabolic process//protein deubiquitination GO:0036459//GO:0005515//GO:0016820//GO:0004674 ubiquitinyl hydrolase activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein serine/threonine kinase activity GO:0016021//GO:0005634//GO:0000221//GO:0030117 integral component of membrane//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain//membrane coat KOG1824 TATA-binding protein-interacting protein Cluster-8309.34832 BP_3 794.27 29.97 1569 642934971 XP_008196003.1 1679 2.1e-184 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] -- -- -- -- -- K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 Q8WY54 679 7.7e-70 Protein phosphatase 1E OS=Homo sapiens GN=PPM1E PE=1 SV=2 PF07228//PF01090//PF00481 Stage II sporulation protein E (SpoIIE)//Ribosomal protein S19e//Protein phosphatase 2C GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840 ribosome KOG0698 Serine/threonine protein phosphatase Cluster-8309.34833 BP_3 2779.46 31.54 4539 642915997 XP_008190849.1 4040 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 381 0 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 1194 4.3e-129 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF13895//PF00041//PF16656//PF02480//PF07714//PF06293//PF00069 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0019497//GO:0006771 protein phosphorylation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0046872//GO:0016773//GO:0003993 protein binding//ATP binding//protein kinase activity//metal ion binding//phosphotransferase activity, alcohol group as acceptor//acid phosphatase activity GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.34834 BP_3 127.00 4.66 1604 478250168 ENN70671.1 1344 1.5e-145 hypothetical protein YQE_12616, partial [Dendroctonus ponderosae]>gi|478270479|gb|ENN83517.1| hypothetical protein YQE_00124, partial [Dendroctonus ponderosae] -- -- -- -- -- K10348 LRR1, PPIL5 LRR-repeat protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10348 Q96L50 475 3.6e-46 Leucine-rich repeat protein 1 OS=Homo sapiens GN=LRR1 PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.34837 BP_3 1472.00 40.51 2043 642917560 XP_008191257.1 1405 1.6e-152 PREDICTED: F-box only protein 25 [Tribolium castaneum] 642917559 XM_008193035.1 256 4.51189e-129 PREDICTED: Tribolium castaneum F-box only protein 25 (LOC659307), mRNA K10305 FBXO25_32 F-box protein 25/32 http://www.genome.jp/dbget-bin/www_bget?ko:K10305 Q1RMS8 382 2.8e-35 F-box only protein 25 OS=Bos taurus GN=FBXO25 PE=2 SV=1 PF00646//PF05864//PF12937//PF01194 F-box domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//F-box-like//RNA polymerases N / 8 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005515 DNA binding//DNA-directed RNA polymerase activity//protein binding GO:0005730 nucleolus KOG3497 DNA-directed RNA polymerase, subunit RPB10 Cluster-8309.34838 BP_3 42.74 0.50 4425 91092696 XP_971938.1 3825 0.0e+00 PREDICTED: trafficking protein particle complex subunit 8 [Tribolium castaneum]>gi|270014865|gb|EFA11313.1| hypothetical protein TcasGA2_TC010852 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2L5 1703 4.0e-188 Trafficking protein particle complex subunit 8 OS=Homo sapiens GN=TRAPPC8 PE=1 SV=2 PF13181//PF00515//PF00377//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Prion/Doppel alpha-helical domain//TPR repeat GO:0051260 protein homooligomerization GO:0005515 protein binding GO:0016020 membrane KOG1938 Protein with predicted involvement in meiosis (GSG1) Cluster-8309.34839 BP_3 17.63 0.33 2856 91083931 XP_974830.1 737 6.4e-75 PREDICTED: N-acetylserotonin O-methyltransferase-like protein [Tribolium castaneum]>gi|270007966|gb|EFA04414.1| hypothetical protein TcasGA2_TC014714 [Tribolium castaneum] -- -- -- -- -- K06287 maf septum formation protein http://www.genome.jp/dbget-bin/www_bget?ko:K06287 Q5KWN2 293 8.1e-25 Septum formation protein Maf OS=Geobacillus kaustophilus (strain HTA426) GN=maf PE=3 SV=1 PF02545//PF15937 Maf-like protein//prlF antitoxin for toxin YhaV_toxin GO:0001558 regulation of cell growth GO:0097351//GO:0003700 toxin-antitoxin pair type II binding//transcription factor activity, sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG1509 Predicted nucleic acid-binding protein ASMTL Cluster-8309.34840 BP_3 251.93 2.56 5035 642912047 XP_008199070.1 2587 3.4e-289 PREDICTED: nuclear factor 1 C-type isoform X1 [Tribolium castaneum]>gi|270014496|gb|EFA10944.1| hypothetical protein TcasGA2_TC001775 [Tribolium castaneum] 642912046 XM_008200848.1 750 0 PREDICTED: Tribolium castaneum nuclear factor 1 C-type (LOC660261), transcript variant X1, mRNA K09172 NFIN nuclear factor I, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09172 P09414 752 8.5e-78 Nuclear factor 1 A-type OS=Rattus norvegicus GN=Nfia PE=1 SV=2 PF03165//PF00859 MH1 domain//CTF/NF-I family transcription modulation region GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634//GO:0005622 transcription factor complex//nucleus//intracellular KOG3663 Nuclear factor I Cluster-8309.34842 BP_3 18.18 0.75 1453 642928117 XP_008200164.1 422 1.1e-38 PREDICTED: protein anoxia up-regulated isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34846 BP_3 279.26 2.08 6763 189234221 XP_972511.2 927 1.4e-96 PREDICTED: zinc finger C4H2 domain-containing protein isoform X1 [Tribolium castaneum] 752869764 XM_011253703.1 65 2.2667e-22 PREDICTED: Camponotus floridanus zinc finger C4H2 domain-containing protein (LOC105248746), transcript variant X4, mRNA -- -- -- -- Q9NQZ6 480 4.0e-46 Zinc finger C4H2 domain-containing protein OS=Homo sapiens GN=ZC4H2 PE=1 SV=1 PF00769//PF03229//PF03854//PF02251 Ezrin/radixin/moesin family//Alphavirus glycoprotein J//P-11 zinc finger//Proteasome activator pa28 alpha subunit GO:0019050 suppression by virus of host apoptotic process GO:0008270//GO:0008092//GO:0003723 zinc ion binding//cytoskeletal protein binding//RNA binding GO:0008537//GO:0005737//GO:0019898 proteasome activator complex//cytoplasm//extrinsic component of membrane -- -- Cluster-8309.34848 BP_3 29.01 2.26 910 91083633 XP_970446.1 331 2.5e-28 PREDICTED: isocitrate dehydrogenase [NADP], mitochondrial [Tribolium castaneum]>gi|270007851|gb|EFA04299.1| hypothetical protein TcasGA2_TC014590 [Tribolium castaneum] -- -- -- -- -- K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 Q04467 304 1.4e-26 Isocitrate dehydrogenase [NADP], mitochondrial OS=Bos taurus GN=IDH2 PE=1 SV=2 PF00180 Isocitrate/isopropylmalate dehydrogenase GO:0006099//GO:0055114//GO:0006749//GO:0006102//GO:0019643 tricarboxylic acid cycle//oxidation-reduction process//glutathione metabolic process//isocitrate metabolic process//reductive tricarboxylic acid cycle GO:0004450//GO:0000287//GO:0051287//GO:0016616 isocitrate dehydrogenase (NADP+) activity//magnesium ion binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.34849 BP_3 6028.57 244.12 1482 91083633 XP_970446.1 1855 7.6e-205 PREDICTED: isocitrate dehydrogenase [NADP], mitochondrial [Tribolium castaneum]>gi|270007851|gb|EFA04299.1| hypothetical protein TcasGA2_TC014590 [Tribolium castaneum] 254582836 XM_002499105.1 96 2.85479e-40 Zygosaccharomyces rouxii hypothetical protein (ZYRO0E05016g) mRNA, complete cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P54071 1580 2.4e-174 Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus GN=Idh2 PE=1 SV=3 PF00180 Isocitrate/isopropylmalate dehydrogenase GO:0055114//GO:0006099//GO:0019643//GO:0006102//GO:0006749 oxidation-reduction process//tricarboxylic acid cycle//reductive tricarboxylic acid cycle//isocitrate metabolic process//glutathione metabolic process GO:0000287//GO:0004450//GO:0016616//GO:0051287 magnesium ion binding//isocitrate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.34850 BP_3 1014.56 36.95 1615 91085239 XP_973002.1 1673 1.1e-183 PREDICTED: 26S proteasome non-ATPase regulatory subunit 13 [Tribolium castaneum]>gi|270009093|gb|EFA05541.1| hypothetical protein TcasGA2_TC015728 [Tribolium castaneum] -- -- -- -- -- K03039 PSMD13, RPN9 26S proteasome regulatory subunit N9 http://www.genome.jp/dbget-bin/www_bget?ko:K03039 P84169 999 6.2e-107 26S proteasome non-ATPase regulatory subunit 13 OS=Gallus gallus GN=PSMD13 PE=1 SV=1 PF00616//PF01399 GTPase-activator protein for Ras-like GTPase//PCI domain GO:0043087 regulation of GTPase activity GO:0005515 protein binding -- -- KOG2908 26S proteasome regulatory complex, subunit RPN9/PSMD13 Cluster-8309.34851 BP_3 42.59 0.85 2707 642937984 XP_008199157.1 245 6.9e-18 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 157 4.5e-09 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34852 BP_3 16.75 0.33 2765 642937984 XP_008199157.1 245 7.0e-18 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 157 4.6e-09 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34854 BP_3 50.85 0.51 5122 347966510 XP_321327.5 384 9.9e-34 AGAP001756-PA [Anopheles gambiae str. PEST]>gi|333470028|gb|EAA01239.5| AGAP001756-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- Q8N4M1 290 3.2e-24 Choline transporter-like protein 3 OS=Homo sapiens GN=SLC44A3 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.34855 BP_3 657.00 18.17 2035 189237849 XP_974842.2 1185 5.2e-127 PREDICTED: uncharacterized protein LOC663715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.34856 BP_3 4.18 2.37 374 91077314 XP_974673.1 680 3.4e-69 PREDICTED: ADAM 17-like protease isoform X2 [Tribolium castaneum]>gi|270002088|gb|EEZ98535.1| hypothetical protein TcasGA2_TC001039 [Tribolium castaneum] -- -- -- -- -- K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 672 1.2e-69 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF01421//PF00413 Reprolysin (M12B) family zinc metalloprotease//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270//GO:0046872 metalloendopeptidase activity//zinc ion binding//metal ion binding GO:0031012 extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.34858 BP_3 526.47 12.63 2301 91090858 XP_967143.1 1222 3.0e-131 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 912 1.1e-96 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- KOG0819 Annexin Cluster-8309.34859 BP_3 321.00 20.93 1031 260832366 XP_002611128.1 221 1.6e-15 hypothetical protein BRAFLDRAFT_88473 [Branchiostoma floridae]>gi|229296499|gb|EEN67138.1| hypothetical protein BRAFLDRAFT_88473 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P82963 159 1.0e-09 Chaoptin (Fragment) OS=Tribolium castaneum GN=CHP PE=2 SV=1 PF00560//PF00001//PF13855 Leucine Rich Repeat//7 transmembrane receptor (rhodopsin family)//Leucine rich repeat GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.34860 BP_3 63.46 1.21 2820 642928510 XP_008193821.1 2484 1.7e-277 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DN14 1091 2.3e-117 Multiple C2 and transmembrane domain-containing protein 1 OS=Homo sapiens GN=MCTP1 PE=2 SV=2 PF00606//PF00168 Herpesvirus Glycoprotein B//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane KOG1030 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.34861 BP_3 54.24 0.72 3900 642923755 XP_008193870.1 936 7.4e-98 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 8.4e-57 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- GO:0051726//GO:0051302//GO:0045859 regulation of cell cycle//regulation of cell division//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.34862 BP_3 667.00 23.21 1677 170056139 XP_001863897.1 842 2.5e-87 3,2-trans-enoyl-CoA isomerase, mitochondrial [Culex quinquefasciatus]>gi|167875865|gb|EDS39248.1| 3,2-trans-enoyl-CoA isomerase, mitochondrial [Culex quinquefasciatus] -- -- -- -- -- K13238 DCI 3,2-trans-enoyl-CoA isomerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K13238 P42125 527 3.5e-52 Enoyl-CoA delta isomerase 1, mitochondrial OS=Mus musculus GN=Eci1 PE=1 SV=2 PF01343//PF16113//PF00378 Peptidase family S49//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016836//GO:0003824//GO:0008233 hydro-lyase activity//catalytic activity//peptidase activity -- -- KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.34863 BP_3 2.00 15.61 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34865 BP_3 4823.92 1031.50 517 264667371 ACY71271.1 744 1.8e-76 ribosomal protein S19 [Chrysomela tremula] -- -- -- -- -- K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 P39018 541 2.6e-54 40S ribosomal protein S19a OS=Drosophila melanogaster GN=RpS19a PE=1 SV=3 PF01090 Ribosomal protein S19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.34866 BP_3 347.67 27.46 902 264667389 ACY71280.1 925 3.2e-97 ribosomal protein S7 [Chrysomela tremula] 752878389 XM_011258375.1 129 7.74751e-59 PREDICTED: Camponotus floridanus 40S ribosomal protein S7-like (LOC105251512), mRNA K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 Q962S0 854 2.3e-90 40S ribosomal protein S7 OS=Spodoptera frugiperda GN=RpS7 PE=2 SV=1 PF01251 Ribosomal protein S7e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3320 40S ribosomal protein S7 Cluster-8309.34867 BP_3 1280.00 41.96 1762 546682654 ERL92566.1 1824 3.6e-201 hypothetical protein D910_09879 [Dendroctonus ponderosae] 674054595 XM_008835479.1 56 5.86509e-18 PREDICTED: Nannospalax galili IK cytokine, down-regulator of HLA II (Ik), mRNA K13109 IK, RED, RER IK cytokine http://www.genome.jp/dbget-bin/www_bget?ko:K13109 Q9Z1M8 738 1.3e-76 Protein Red OS=Mus musculus GN=Ik PE=1 SV=2 PF01496//PF00639//PF07808 V-type ATPase 116kDa subunit family//PPIC-type PPIASE domain//RED-like protein N-terminal region GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0016853//GO:0015078 isomerase activity//hydrogen ion transmembrane transporter activity GO:0033179//GO:0005634 proton-transporting V-type ATPase, V0 domain//nucleus KOG2498 IK cytokine down-regulator of HLA class II Cluster-8309.34868 BP_3 865.80 18.02 2607 642928513 XP_008193822.1 1635 4.4e-179 PREDICTED: uncharacterized protein LOC659984 [Tribolium castaneum] 299884466 FP926002.1 78 5.14661e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51023 606 3.7e-61 ETS-like protein pointed, isoform P2/D OS=Drosophila melanogaster GN=pnt PE=2 SV=2 PF00178//PF00447//PF02198 Ets-domain//HSF-type DNA-binding//Sterile alpha motif (SAM)/Pointed domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.34869 BP_3 751.69 8.80 4408 91080113 XP_967415.1 1588 2.1e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit I [Tribolium castaneum]>gi|270003188|gb|EEZ99635.1| hypothetical protein TcasGA2_TC002391 [Tribolium castaneum] 642918634 XM_962322.2 236 1.28848e-117 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 3 subunit I (LOC655760), mRNA K03246 EIF3I translation initiation factor 3 subunit I http://www.genome.jp/dbget-bin/www_bget?ko:K03246 Q1HPW4 1315 3.9e-143 Eukaryotic translation initiation factor 3 subunit I OS=Bombyx mori PE=2 SV=1 PF04053//PF00400//PF10505//PF10766 Coatomer WD associated region//WD domain, G-beta repeat//NMDA receptor-regulated gene protein 2 C-terminus//Multidrug efflux pump-associated protein AcrZ GO:0006855//GO:0006886//GO:0016192//GO:0015893 drug transmembrane transport//intracellular protein transport//vesicle-mediated transport//drug transport GO:0005198//GO:0015238//GO:0005515 structural molecule activity//drug transmembrane transporter activity//protein binding GO:0030117//GO:0008023//GO:0005886 membrane coat//transcription elongation factor complex//plasma membrane KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) Cluster-8309.34870 BP_3 515.00 316.01 367 91092288 XP_968701.1 166 1.3e-09 PREDICTED: up-regulated during skeletal muscle growth protein 5 [Tribolium castaneum]>gi|270001315|gb|EEZ97762.1| Neb-cGP [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.34871 BP_3 14.57 1.06 956 642931531 XP_008196624.1 276 6.1e-22 PREDICTED: 28 kDa heat- and acid-stable phosphoprotein-like [Tribolium castaneum]>gi|270011801|gb|EFA08249.1| hypothetical protein TcasGA2_TC005877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q13442 179 4.5e-12 28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens GN=PDAP1 PE=1 SV=1 PF03985 Paf1 GO:0006368//GO:0016570 transcription elongation from RNA polymerase II promoter//histone modification -- -- GO:0016593 Cdc73/Paf1 complex KOG3375 Phosphoprotein/predicted coiled-coil protein Cluster-8309.34873 BP_3 281.53 3.06 4731 642916721 XP_008192340.1 738 8.2e-75 PREDICTED: coiled-coil domain-containing protein 102A isoform X3 [Tribolium castaneum]>gi|270004300|gb|EFA00748.1| hypothetical protein TcasGA2_TC003630 [Tribolium castaneum] -- -- -- -- -- K16759 CCDC102A coiled-coil domain-containing protein 102A http://www.genome.jp/dbget-bin/www_bget?ko:K16759 Q96A19 384 3.8e-35 Coiled-coil domain-containing protein 102A OS=Homo sapiens GN=CCDC102A PE=1 SV=2 PF16331//PF06009//PF04977//PF06008//PF04508//PF06810//PF00509//PF10174//PF05837//PF07989//PF04799//PF08702//PF04513//PF04871//PF06160//PF11365//PF00769//PF05557//PF07851//PF08287//PF05478//PF04632//PF07058//PF10392//PF13851//PF01920//PF03938//PF07926//PF09728//PF02601//PF11403//PF03233//PF00038//PF04111//PF04048//PF01576//PF06005//PF10473//PF00015//PF04136//PF02050 TolA binding protein trimerisation//Laminin Domain II//Septum formation initiator//Laminin Domain I//Viral A-type inclusion protein repeat//Phage minor structural protein GP20//Haemagglutinin//RIM-binding protein of the cytomatrix active zone//Centromere protein H (CENP-H)//Centrosomin N-terminal motif 1//fzo-like conserved region//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Uso1 / p115 like vesicle tethering protein, C terminal region//Septation ring formation regulator, EzrA//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Mitotic checkpoint protein//TMPIT-like protein//Spc19//Prominin//Fusaric acid resistance protein family//Microtubule-associated protein 70//Golgi transport complex subunit 5//Growth-arrest specific micro-tubule binding//Prefoldin subunit//Outer membrane protein (OmpH-like)//TPR/MLP1/MLP2-like protein//Myosin-like coiled-coil protein//Exonuclease VII, large subunit//Yeast metallothionein//Aphid transmission protein//Intermediate filament protein//Autophagy protein Apg6//Sec8 exocyst complex component specific domain//Myosin tail//Protein of unknown function (DUF904)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family//Flagellar FliJ protein GO:0008608//GO:0010506//GO:0051382//GO:0030168//GO:0006891//GO:0016032//GO:0019089//GO:0048870//GO:0015031//GO:0007049//GO:0007165//GO:0006810//GO:0007010//GO:0070206//GO:0006886//GO:0006914//GO:0007094//GO:0043093//GO:0000917//GO:0006457//GO:0019064//GO:0006606//GO:0045995//GO:0008053//GO:0006935//GO:0000921//GO:0006904//GO:0071973//GO:0010273//GO:0030334//GO:0071585//GO:0051258//GO:0007155//GO:0030155//GO:0006308 attachment of spindle microtubules to kinetochore//regulation of autophagy//kinetochore assembly//platelet activation//intra-Golgi vesicle-mediated transport//viral process//transmission of virus//cell motility//protein transport//cell cycle//signal transduction//transport//cytoskeleton organization//protein trimerization//intracellular protein transport//autophagy//mitotic spindle assembly checkpoint//FtsZ-dependent cytokinesis//barrier septum assembly//protein folding//fusion of virus membrane with host plasma membrane//protein import into nucleus//regulation of embryonic development//mitochondrial fusion//chemotaxis//septin ring assembly//vesicle docking involved in exocytosis//bacterial-type flagellum-dependent cell motility//detoxification of copper ion//regulation of cell migration//detoxification of cadmium ion//protein polymerization//cell adhesion//regulation of cell adhesion//DNA catabolic process GO:0005102//GO:0051082//GO:0046870//GO:0045502//GO:0003924//GO:0003774//GO:0030674//GO:0019905//GO:0008565//GO:0008017//GO:0042803//GO:0008134//GO:0008092//GO:0005198//GO:0004871//GO:0046789//GO:0005507//GO:0008855 receptor binding//unfolded protein binding//cadmium ion binding//dynein binding//GTPase activity//motor activity//protein binding, bridging//syntaxin binding//protein transporter activity//microtubule binding//protein homodimerization activity//transcription factor binding//cytoskeletal protein binding//structural molecule activity//signal transducer activity//host cell surface receptor binding//copper ion binding//exodeoxyribonuclease VII activity GO:0009288//GO:0016272//GO:0005615//GO:0019028//GO:0045298//GO:0000776//GO:0005667//GO:0005801//GO:0031514//GO:0016020//GO:0017119//GO:0005741//GO:0005886//GO:0009318//GO:0048786//GO:0005577//GO:0019898//GO:0005882//GO:0009986//GO:0030286//GO:0042729//GO:0005737//GO:0005876//GO:0016459//GO:0016021//GO:0005815//GO:0005940//GO:0000145//GO:0019031 bacterial-type flagellum//prefoldin complex//extracellular space//viral capsid//tubulin complex//kinetochore//transcription factor complex//cis-Golgi network//motile cilium//membrane//Golgi transport complex//mitochondrial outer membrane//plasma membrane//exodeoxyribonuclease VII complex//presynaptic active zone//fibrinogen complex//extrinsic component of membrane//intermediate filament//cell surface//dynein complex//DASH complex//cytoplasm//spindle microtubule//myosin complex//integral component of membrane//microtubule organizing center//septin ring//exocyst//viral envelope -- -- Cluster-8309.34876 BP_3 1549.76 15.80 5020 642914078 XP_969963.3 2013 1.2e-222 PREDICTED: uncharacterized protein LOC658486 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15898//PF17078//PF05529//PF15177 cGMP-dependent protein kinase interacting domain//SWI5-dependent HO expression protein 3//B-cell receptor-associated protein 31-like//Interleukin-28A GO:0051028//GO:0051607//GO:0050778//GO:0006886//GO:0048309//GO:0007165//GO:0007259 mRNA transport//defense response to virus//positive regulation of immune response//intracellular protein transport//endoplasmic reticulum inheritance//signal transduction//JAK-STAT cascade GO:0019901//GO:0005125 protein kinase binding//cytokine activity GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane -- -- Cluster-8309.34878 BP_3 130.45 1.90 3596 571568658 XP_006565113.1 324 6.3e-27 PREDICTED: optineurin isoform X2 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88522 179 1.7e-11 NF-kappa-B essential modulator OS=Mus musculus GN=Ikbkg PE=1 SV=2 PF08287//PF06160//PF07651//PF10186//PF13851//PF02183 Spc19//Septation ring formation regulator, EzrA//ANTH domain//Vacuolar sorting 38 and autophagy-related subunit 14//Growth-arrest specific micro-tubule binding//Homeobox associated leucine zipper GO:0008608//GO:0006355//GO:0010508//GO:0048870//GO:0000921 attachment of spindle microtubules to kinetochore//regulation of transcription, DNA-templated//positive regulation of autophagy//cell motility//septin ring assembly GO:0043565//GO:0003700//GO:0005543 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//phospholipid binding GO:0042729//GO:0005876//GO:0016021//GO:0031514//GO:0005667//GO:0005940 DASH complex//spindle microtubule//integral component of membrane//motile cilium//transcription factor complex//septin ring -- -- Cluster-8309.34879 BP_3 18.43 0.36 2791 478256708 ENN76890.1 2352 3.4e-262 hypothetical protein YQE_06731, partial [Dendroctonus ponderosae] -- -- -- -- -- K08766 CPT2 carnitine O-palmitoyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08766 Q5U3U3 1577 1.0e-173 Carnitine O-palmitoyltransferase 2, mitochondrial OS=Danio rerio GN=cpt2 PE=2 SV=2 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3719 Carnitine O-acyltransferase CPT2/YAT1 Cluster-8309.34880 BP_3 9.85 0.34 1672 332373138 AEE61710.1 1814 4.9e-200 unknown [Dendroctonus ponderosae] 374719504 JN671475.1 117 6.84413e-52 Buccinum sp. JV-2012 catalase (cat) gene, partial cds K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P04040 1494 2.6e-164 Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 PF00199 Catalase GO:0006568//GO:0015947//GO:0006979//GO:0055114//GO:0006804 tryptophan metabolic process//methane metabolic process//response to oxidative stress//oxidation-reduction process//obsolete peroxidase reaction GO:0004096//GO:0020037 catalase activity//heme binding -- -- KOG0047 Catalase Cluster-8309.34882 BP_3 1171.75 20.26 3080 385845164 AFI81409.1 1440 2.1e-156 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 57 2.87339e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 586 9.2e-59 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF03099//PF08127 Biotin/lipoate A/B protein ligase family//Peptidase family C1 propeptide GO:0006508//GO:0006464//GO:0050790 proteolysis//cellular protein modification process//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.34884 BP_3 120.71 2.36 2761 281345976 EFB21560.1 509 1.7e-48 hypothetical protein PANDA_020762 [Ailuropoda melanoleuca] -- -- -- -- -- -- -- -- -- Q6ZMW2 488 1.9e-47 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF04810//PF01363//PF02776//PF13912//PF01428//PF01844//PF02072//PF10503//PF06467//PF00130//PF01155//PF00412//PF02892//PF16622//PF05191//PF13465 Zinc finger, C2H2 type//Sec23/Sec24 zinc finger//FYVE zinc finger//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//C2H2-type zinc finger//AN1-like Zinc finger//HNH endonuclease//Prepro-orexin//Esterase PHB depolymerase//MYM-type Zinc finger with FCS sequence motif//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//LIM domain//BED zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc-finger double domain GO:0006464//GO:0007631//GO:0046034//GO:0006886//GO:0035556//GO:0006144//GO:0006888//GO:0007218 cellular protein modification process//feeding behavior//ATP metabolic process//intracellular protein transport//intracellular signal transduction//purine nucleobase metabolic process//ER to Golgi vesicle-mediated transport//neuropeptide signaling pathway GO:0008270//GO:0004017//GO:0004519//GO:0003677//GO:0016151//GO:0003676//GO:0046872//GO:0030976 zinc ion binding//adenylate kinase activity//endonuclease activity//DNA binding//nickel cation binding//nucleic acid binding//metal ion binding//thiamine pyrophosphate binding GO:0030127//GO:0005576 COPII vesicle coat//extracellular region -- -- Cluster-8309.34886 BP_3 2.00 0.60 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34887 BP_3 877.17 5.13 8530 91088973 XP_966480.1 3207 0.0e+00 PREDICTED: G protein-coupled receptor kinase 1 [Tribolium castaneum]>gi|270011553|gb|EFA08001.1| hypothetical protein TcasGA2_TC005590 [Tribolium castaneum] 642932569 XM_961387.2 842 0 PREDICTED: Tribolium castaneum G protein-coupled receptor kinase 1 (LOC654946), mRNA K00910 ADRBK, GRK beta-adrenergic-receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00910 P32865 2867 0.0e+00 G protein-coupled receptor kinase 1 OS=Drosophila melanogaster GN=Gprk1 PE=2 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0016310//GO:0006468//GO:0009069//GO:0038032 phosphorylation//protein phosphorylation//serine family amino acid metabolic process//termination of G-protein coupled receptor signaling pathway GO:0004672//GO:0004703//GO:0016773//GO:0005524 protein kinase activity//G-protein coupled receptor kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0986 G protein-coupled receptor kinase Cluster-8309.34889 BP_3 306.00 5.57 2939 270015239 EFA11687.1 612 2.1e-60 hypothetical protein TcasGA2_TC008551 [Tribolium castaneum] -- -- -- -- -- K16804 DLGAP5, DLG7 disks large-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16804 Q7K3L1 284 9.2e-24 Guanylate kinase-associated protein mars OS=Drosophila melanogaster GN=mars PE=1 SV=1 PF03359 Guanylate-kinase-associated protein (GKAP) protein GO:0023052 signaling -- -- -- -- -- -- Cluster-8309.34890 BP_3 111.82 5.04 1361 -- -- -- -- -- 99029204 DQ515965.1 46 1.63116e-12 Leptinotarsa decemlineata putative glycine-rich protein (GRP1) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34891 BP_3 26.00 3.78 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34892 BP_3 34.61 0.74 2549 642929562 XP_008195885.1 3634 0.0e+00 PREDICTED: ankyrin repeat and IBR domain-containing protein 1-like [Tribolium castaneum]>gi|270010556|gb|EFA07004.1| hypothetical protein TcasGA2_TC009974 [Tribolium castaneum] -- -- -- -- -- K11967 ANKIB1 ankyrin repeat and IBR domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11967 Q6ZPS6 1901 2.5e-211 Ankyrin repeat and IBR domain-containing protein 1 OS=Mus musculus GN=Ankib1 PE=1 SV=2 PF00097//PF00023//PF14634//PF13606//PF13639 Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//zinc-RING finger domain//Ankyrin repeat//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.34894 BP_3 81.00 21.86 470 -- -- -- -- -- 56968035 AY859581.1 206 6.12627e-102 Homarus americanus internal transcribed spacer 2 and 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34896 BP_3 361.67 5.65 3376 270006170 EFA02618.1 2777 2.6e-311 hypothetical protein TcasGA2_TC008338 [Tribolium castaneum] -- -- -- -- -- K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 A8Y236 1566 2.3e-172 Putative polypeptide N-acetylgalactosaminyltransferase 10 OS=Caenorhabditis briggsae GN=gly-10 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.34897 BP_3 14.57 0.32 2505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.34898 BP_3 450.61 4.62 4994 478252696 ENN73092.1 2419 1.0e-269 hypothetical protein YQE_10296, partial [Dendroctonus ponderosae] -- -- -- -- -- K04681 RBL1 retinoblastoma-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04681 Q64701 1034 1.7e-110 Retinoblastoma-like protein 1 OS=Mus musculus GN=Rbl1 PE=1 SV=3 PF01857//PF01858 Retinoblastoma-associated protein B domain//Retinoblastoma-associated protein A domain GO:0051726 regulation of cell cycle -- -- GO:0005634 nucleus KOG1010 Rb (Retinoblastoma tumor suppressor)-related protein Cluster-8309.34899 BP_3 7.51 0.83 729 264667323 ACY71247.1 710 2.2e-72 ribosomal protein S13 [Chrysomela tremula] 26190492 AY174891.1 105 1.36193e-45 Plutella xylostella ribosomal protein S13 mRNA, complete cds K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 Q962R6 667 8.8e-69 40S ribosomal protein S13 OS=Spodoptera frugiperda GN=RpS13 PE=2 SV=3 PF08069//PF00312 Ribosomal S13/S15 N-terminal domain//Ribosomal protein S15 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0400 40S ribosomal protein S13 Cluster-8309.3490 BP_3 2.07 0.31 616 270010586 EFA07034.1 434 1.9e-40 hypothetical protein TcasGA2_TC010006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34900 BP_3 1183.29 7.75 7654 642912355 XP_008199607.1 1480 1.2e-160 PREDICTED: PHD and RING finger domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270002669|gb|EEZ99116.1| hypothetical protein TcasGA2_TC005009 [Tribolium castaneum] -- -- -- -- -- K17586 PHRF1 PHD and RING finger domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17586 Q9P1Y6 556 6.9e-55 PHD and RING finger domain-containing protein 1 OS=Homo sapiens GN=PHRF1 PE=1 SV=3 PF13639//PF13994//PF12861//PF00130//PF00628//PF14634//PF12678//PF00097 Ring finger domain//PgaD-like protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0042710//GO:0035556 protein ubiquitination//biofilm formation//intracellular signal transduction GO:0005515//GO:0004842//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0825 PHD Zn-finger protein Cluster-8309.34901 BP_3 9487.40 120.01 4102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03893 Lipase 3 N-terminal region GO:0016042 lipid catabolic process -- -- -- -- -- -- Cluster-8309.34902 BP_3 310.82 5.84 2855 642925940 XP_008194704.1 1419 5.3e-154 PREDICTED: alpha-1D adrenergic receptor [Tribolium castaneum]>gi|270009238|gb|EFA05686.1| hypothetical protein TcasGA2_TC015120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TTM9 138 7.6e-07 Alpha-1D adrenergic receptor OS=Sus scrofa GN=ADRA1D PE=3 SV=1 PF08099//PF00001 Scorpion calcine family//7 transmembrane receptor (rhodopsin family) GO:0009405//GO:0007186//GO:0006810 pathogenesis//G-protein coupled receptor signaling pathway//transport GO:0004930//GO:0019855 G-protein coupled receptor activity//calcium channel inhibitor activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.34904 BP_3 841.00 17.23 2645 189240338 XP_970612.2 996 5.5e-105 PREDICTED: probable phosphomannomutase [Tribolium castaneum] -- -- -- -- -- K17497 PMM phosphomannomutase http://www.genome.jp/dbget-bin/www_bget?ko:K17497 Q9VTZ6 770 3.7e-80 Probable phosphomannomutase OS=Drosophila melanogaster GN=CG10688 PE=2 SV=1 PF03332//PF16113//PF00378//PF01972 Eukaryotic phosphomannomutase//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//Serine dehydrogenase proteinase GO:0006000//GO:0006013//GO:0009298//GO:0008152 fructose metabolic process//mannose metabolic process//GDP-mannose biosynthetic process//metabolic process GO:0004615//GO:0016836//GO:0003824 phosphomannomutase activity//hydro-lyase activity//catalytic activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane KOG3189 Phosphomannomutase Cluster-8309.34905 BP_3 1355.75 10.51 6512 546679248 ERL89742.1 2986 0.0e+00 hypothetical protein D910_07103 [Dendroctonus ponderosae] 641702319 XM_008141598.1 150 1.22359e-69 PREDICTED: Eptesicus fuscus ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), transcript variant X3, mRNA K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 2217 1.5e-247 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 PF15499//PF00917//PF00443 Ubiquitin-specific peptidase-like, SUMO isopeptidase//MATH domain//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0032183//GO:0070140//GO:0005515 ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity//protein binding -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.34907 BP_3 475.28 14.64 1857 478250085 ENN70591.1 1469 5.5e-160 hypothetical protein YQE_12766, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 322 2.3e-28 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856//PF11744 SET domain//Aluminium activated malate transporter GO:0015743 malate transport GO:0005515 protein binding -- -- -- -- Cluster-8309.34909 BP_3 17.00 0.98 1132 91095123 XP_970890.1 587 6.3e-58 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 397 2.8e-37 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF16794//PF00106 Fibronectin-III type domain//short chain dehydrogenase GO:0008152 metabolic process GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- -- -- Cluster-8309.34911 BP_3 82.87 5.21 1059 91089683 XP_974633.1 496 2.1e-47 PREDICTED: survival of motor neuron-related-splicing factor 30 [Tribolium castaneum]>gi|270011328|gb|EFA07776.1| hypothetical protein TcasGA2_TC005331 [Tribolium castaneum] -- -- -- -- -- K12839 SMNDC1, SPF30 survival of motor neuron-related-splicing factor 30 http://www.genome.jp/dbget-bin/www_bget?ko:K12839 Q7ZV80 162 4.6e-10 Survival of motor neuron-related-splicing factor 30 OS=Danio rerio GN=smndc1 PE=2 SV=1 PF06003//PF03039//PF02294 Survival motor neuron protein (SMN)//Interleukin-12 alpha subunit//7kD DNA-binding domain GO:0006955//GO:0051252//GO:0040007//GO:0007165//GO:0006397//GO:0008283 immune response//regulation of RNA metabolic process//growth//signal transduction//mRNA processing//cell proliferation GO:0005143//GO:0003723//GO:0008083//GO:0003677//GO:0004521 interleukin-12 receptor binding//RNA binding//growth factor activity//DNA binding//endoribonuclease activity GO:0005576//GO:0005737//GO:0005634//GO:0042022 extracellular region//cytoplasm//nucleus//interleukin-12 receptor complex -- -- Cluster-8309.34913 BP_3 0.82 9.62 239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34916 BP_3 57.82 2.98 1228 642910461 XP_008190748.1 505 2.2e-48 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 298 9.1e-26 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34919 BP_3 183.93 11.33 1074 91077504 XP_966852.1 517 7.8e-50 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 O13035 298 8.0e-26 Proactivator polypeptide OS=Gallus gallus GN=PSAP PE=1 SV=1 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.34920 BP_3 856.17 8.37 5220 91092978 XP_967458.1 1021 1.4e-107 PREDICTED: type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [Tribolium castaneum]>gi|270004800|gb|EFA01248.1| hypothetical protein TcasGA2_TC002125 [Tribolium castaneum] 827558552 XM_012694950.1 58 1.36056e-18 PREDICTED: Bombyx mori TPPP family protein CG45057-like (LOC101741645), transcript variant X2, mRNA K13084 TMEM55 phosphatidylinositol-4,5-bisphosphate 4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K13084 Q4R6W2 542 2.0e-53 Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Macaca fascicularis GN=TMEM55B PE=2 SV=1 PF09788//PF13903//PF02892 Transmembrane protein 55A//PMP-22/EMP/MP20/Claudin tight junction//BED zinc finger GO:0046856 phosphatidylinositol dephosphorylation GO:0003677//GO:0034597 DNA binding//phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity GO:0016021 integral component of membrane KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger Cluster-8309.34921 BP_3 78.49 0.48 8102 478254915 ENN75149.1 2582 2.1e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.68734e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.7e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF00665//PF13683//PF01534//PF01392//PF08465 Integrase core domain//Integrase core domain//Frizzled/Smoothened family membrane region//Fz domain//Thymidine kinase from Herpesvirus C-terminal GO:0006206//GO:0015074//GO:0007166//GO:0006230 pyrimidine nucleobase metabolic process//DNA integration//cell surface receptor signaling pathway//TMP biosynthetic process GO:0004797//GO:0005524//GO:0005515 thymidine kinase activity//ATP binding//protein binding GO:0016020 membrane -- -- Cluster-8309.34923 BP_3 40.00 7.27 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34924 BP_3 15.00 2.97 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34925 BP_3 1721.03 118.97 989 91092672 XP_971117.1 1205 1.2e-129 PREDICTED: phosphoglycerate mutase 1 [Tribolium castaneum]>gi|270014862|gb|EFA11310.1| hypothetical protein TcasGA2_TC010847 [Tribolium castaneum] -- -- -- -- -- K01834 PGAM, gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01834 Q3SZ62 915 2.1e-97 Phosphoglycerate mutase 1 OS=Bos taurus GN=PGAM1 PE=2 SV=3 -- -- GO:0006094//GO:0006096 gluconeogenesis//glycolytic process GO:0004619 phosphoglycerate mutase activity -- -- KOG0235 Phosphoglycerate mutase Cluster-8309.34926 BP_3 1881.00 1000.99 380 557007445 XP_006005038.1 484 1.9e-46 PREDICTED: ubiquitin-60S ribosomal protein L40-like [Latimeria chalumnae] 462366006 APGK01027402.1 124 1.86463e-56 Dendroctonus ponderosae Seq01027412, whole genome shotgun sequence K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P0CH06 474 1.1e-46 Ubiquitin-60S ribosomal protein L40 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubi1 PE=1 SV=1 PF00240//PF01020 Ubiquitin family//Ribosomal L40e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-8309.34927 BP_3 4.00 1.63 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34928 BP_3 2326.96 40.65 3051 642913496 XP_008201037.1 1087 1.8e-115 PREDICTED: uncharacterized protein LOC100142275 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34930 BP_3 734.00 194.87 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34931 BP_3 16658.18 580.45 1675 -- -- -- -- -- 99029204 DQ515965.1 46 2.01742e-12 Leptinotarsa decemlineata putative glycine-rich protein (GRP1) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34932 BP_3 544.89 45.03 875 270011202 EFA07650.1 694 1.9e-70 hypothetical protein TcasGA2_TC030561 [Tribolium castaneum] -- -- -- -- -- K10428 DCTN6 dynactin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10428 Q5R7D8 443 1.0e-42 Dynactin subunit 6 OS=Pongo abelii GN=DCTN6 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- KOG4042 Dynactin subunit p27/WS-3, involved in transport of organelles along microtubules Cluster-8309.34933 BP_3 270.84 5.27 2771 642924584 XP_008194352.1 3907 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 8 isoform X2 [Tribolium castaneum] 462337280 APGK01037611.1 80 4.22938e-31 Dendroctonus ponderosae Seq01037621, whole genome shotgun sequence -- -- -- -- P60882 1400 3.4e-153 Multiple epidermal growth factor-like domains protein 8 OS=Mus musculus GN=Megf8 PE=2 SV=2 PF01437//PF01344//PF07645//PF07646 Plexin repeat//Kelch motif//Calcium-binding EGF domain//Kelch motif -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.34934 BP_3 20.00 1.97 781 642913522 XP_008201049.1 522 1.5e-50 PREDICTED: venom allergen 3-like [Tribolium castaneum]>gi|270001720|gb|EEZ98167.1| hypothetical protein TcasGA2_TC000596 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- W4VS53 269 1.3e-22 CRISP/Allergen/PR-1 OS=Trittame loki PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3017 Defense-related protein containing SCP domain Cluster-8309.34935 BP_3 5.00 0.97 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34936 BP_3 955.00 25.08 2127 189233693 XP_969378.2 1908 7.9e-211 PREDICTED: sorting nexin-17 [Tribolium castaneum]>gi|642910711|ref|XP_008200527.1| PREDICTED: sorting nexin-17 [Tribolium castaneum] -- -- -- -- -- K17929 SNX17 sorting nexin-17 http://www.genome.jp/dbget-bin/www_bget?ko:K17929 Q5RID7 1024 1.0e-109 Sorting nexin-17 OS=Danio rerio GN=snx17 PE=2 SV=1 PF00787//PF04574 PX domain//Protein of unknown function (DUF592) GO:0006355//GO:0006807//GO:0006476//GO:0006342 regulation of transcription, DNA-templated//nitrogen compound metabolic process//protein deacetylation//chromatin silencing GO:0008270//GO:0016811//GO:0035091//GO:0017136//GO:0051287 zinc ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//phosphatidylinositol binding//NAD-dependent histone deacetylase activity//NAD binding GO:0000118 histone deacetylase complex KOG3784 Sorting nexin protein SNX27 Cluster-8309.34937 BP_3 132.72 3.08 2369 270008370 EFA04818.1 1154 2.4e-123 hypothetical protein TcasGA2_TC014868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SWR8 600 1.7e-60 Ataxin-2 homolog OS=Drosophila melanogaster GN=Atx2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2375 Protein interacting with poly(A)-binding protein Cluster-8309.34938 BP_3 3297.46 43.10 3979 270012994 EFA09442.1 3262 0.0e+00 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61824 1131 7.6e-122 Disintegrin and metalloproteinase domain-containing protein 12 OS=Mus musculus GN=Adam12 PE=1 SV=2 PF01562//PF06701//PF10462//PF00413//PF07998//PF08516//PF01421 Reprolysin family propeptide//Mib_herc2//Peptidase M66//Matrixin//Peptidase family M54//ADAM cysteine-rich//Reprolysin (M12B) family zinc metalloprotease GO:0016567//GO:0006508 protein ubiquitination//proteolysis GO:0004842//GO:0046872//GO:0008270//GO:0004222 ubiquitin-protein transferase activity//metal ion binding//zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family Cluster-8309.34940 BP_3 1.00 9.36 245 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34941 BP_3 2786.80 37.72 3853 642934754 XP_967096.2 1811 2.5e-199 PREDICTED: sorting nexin-30 [Tribolium castaneum] 642934008 XM_008199379.1 181 4.22135e-87 PREDICTED: Tribolium castaneum interferon-related developmental regulator 2 (LOC662460), mRNA K17921 SNX7_30 sorting nexin-7/30 http://www.genome.jp/dbget-bin/www_bget?ko:K17921 Q12894 597 6.1e-60 Interferon-related developmental regulator 2 OS=Homo sapiens GN=IFRD2 PE=1 SV=3 PF03114//PF02985//PF00787 BAR domain//HEAT repeat//PX domain -- -- GO:0035091//GO:0005515 phosphatidylinositol binding//protein binding GO:0005737 cytoplasm KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.34942 BP_3 1831.22 41.59 2414 332374254 AEE62268.1 1568 2.4e-171 unknown [Dendroctonus ponderosae]>gi|546686166|gb|ERL95552.1| hypothetical protein D910_12813 [Dendroctonus ponderosae] -- -- -- -- -- K09507 DNAJB1 DnaJ homolog subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09507 Q24133 1004 2.4e-107 DnaJ protein homolog 1 OS=Drosophila melanogaster GN=DnaJ-1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.34943 BP_3 49.28 0.46 5405 91094647 XP_971886.1 3461 0.0e+00 PREDICTED: protein transport protein Sec24C [Tribolium castaneum]>gi|270016466|gb|EFA12912.1| hypothetical protein TcasGA2_TC006982 [Tribolium castaneum] 751205538 XM_011178054.1 47 1.83574e-12 PREDICTED: Solenopsis invicta protein transport protein Sec24C (LOC105208248), mRNA K14007 SEC24 protein transport protein SEC24 http://www.genome.jp/dbget-bin/www_bget?ko:K14007 P53992 2289 5.4e-256 Protein transport protein Sec24C OS=Homo sapiens GN=SEC24C PE=1 SV=3 PF04811//PF04810//PF04815 Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger//Sec23/Sec24 helical domain GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1984 Vesicle coat complex COPII, subunit SFB3 Cluster-8309.34944 BP_3 507.98 3.79 6750 189237751 XP_001812575.1 3801 0.0e+00 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 1.0e-81 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF00787//PF04769//PF08070 PX domain//Mating-type protein MAT alpha 1 HMG-box//DTHCT (NUC029) region GO:0007531//GO:0006265//GO:0045895 mating type determination//DNA topological change//positive regulation of mating-type specific transcription, DNA-templated GO:0035091//GO:0003677//GO:0005524//GO:0008301//GO:0003918 phosphatidylinositol binding//DNA binding//ATP binding//DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.34946 BP_3 195.27 0.51 18570 612342210 AHW99830.1 23489 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1528 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 19793 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00622//PF00520//PF01365//PF00487//PF06423//PF06459//PF02815 SPRY domain//Ion transport protein//RIH domain//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//MIR domain GO:0006874//GO:0070588//GO:0006816//GO:0055085//GO:0006811//GO:0006506//GO:0006629 cellular calcium ion homeostasis//calcium ion transmembrane transport//calcium ion transport//transmembrane transport//ion transport//GPI anchor biosynthetic process//lipid metabolic process GO:0005216//GO:0005515//GO:0005219//GO:0016746//GO:0005262 ion channel activity//protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium channel activity GO:0005622//GO:0016021//GO:0016020//GO:0005789 intracellular//integral component of membrane//membrane//endoplasmic reticulum membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.34947 BP_3 14.50 0.54 1578 17981530 AAL51056.1 1700 7.7e-187 cathepsin D [Apriona germari] 17981529 AF454831.1 166 3.72122e-79 AF454831 Apriona germari cathepsin D mRNA, complete cds K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 1399 2.5e-153 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF07966//PF00026 A1 Propeptide//Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG1339 Aspartyl protease Cluster-8309.34949 BP_3 532.33 9.96 2868 642926986 XP_008195091.1 2065 6.6e-229 PREDICTED: probable ATP-dependent RNA helicase DDX27 [Tribolium castaneum]>gi|270010045|gb|EFA06493.1| hypothetical protein TcasGA2_TC009390 [Tribolium castaneum] -- -- -- -- -- K13181 DDX27, DRS1 ATP-dependent RNA helicase DDX27 http://www.genome.jp/dbget-bin/www_bget?ko:K13181 A1A4H6 1365 4.0e-149 Probable ATP-dependent RNA helicase DDX27 OS=Bos taurus GN=DDX27 PE=2 SV=1 PF00270//PF02068//PF01459 DEAD/DEAH box helicase//Plant PEC family metallothionein//Eukaryotic porin GO:0055085 transmembrane transport GO:0005524//GO:0008270//GO:0000166//GO:0004386//GO:0003676 ATP binding//zinc ion binding//nucleotide binding//helicase activity//nucleic acid binding GO:0005741 mitochondrial outer membrane KOG0338 ATP-dependent RNA helicase Cluster-8309.34950 BP_3 231.86 3.55 3440 642911103 XP_008200578.1 2635 6.4e-295 PREDICTED: twitchin isoform X6 [Tribolium castaneum] 642911108 XM_008202360.1 709 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X9, mRNA -- -- -- -- Q23551 419 2.4e-39 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF13895//PF02480 Immunoglobulin domain//Alphaherpesvirus glycoprotein E -- -- GO:0005515 protein binding GO:0016020 membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.34951 BP_3 42.25 0.51 4303 642911095 XP_008200574.1 2030 1.1e-224 PREDICTED: twitchin isoform X2 [Tribolium castaneum] 642911110 XM_008202361.1 549 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- O01761 403 2.1e-37 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF02480//PF13895 Alphaherpesvirus glycoprotein E//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.34954 BP_3 7.97 0.51 1050 91092672 XP_971117.1 975 6.0e-103 PREDICTED: phosphoglycerate mutase 1 [Tribolium castaneum]>gi|270014862|gb|EFA11310.1| hypothetical protein TcasGA2_TC010847 [Tribolium castaneum] -- -- -- -- -- K01834 PGAM, gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01834 P15259 715 3.5e-74 Phosphoglycerate mutase 2 OS=Homo sapiens GN=PGAM2 PE=1 SV=3 -- -- GO:0006096//GO:0006094 glycolytic process//gluconeogenesis GO:0004619 phosphoglycerate mutase activity -- -- KOG0235 Phosphoglycerate mutase Cluster-8309.34955 BP_3 27.58 0.33 4338 589060794 AHK26790.1 1854 2.9e-204 heat shock 70 kDa protein cognate 5-like protein [Epicauta chinensis] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 5.6e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF15281//PF12634//PF13414//PF02782//PF06723//PF00516 Consortin C-terminus//Inheritance of peroxisomes protein 1//TPR repeat//FGGY family of carbohydrate kinases, C-terminal domain//MreB/Mbl protein//Envelope glycoprotein GP120 GO:0045033//GO:0000902//GO:0005975//GO:0042998 peroxisome inheritance//cell morphogenesis//carbohydrate metabolic process//positive regulation of Golgi to plasma membrane protein transport GO:0016773//GO:0005515//GO:0071253 phosphotransferase activity, alcohol group as acceptor//protein binding//connexin binding GO:0005780//GO:0005802//GO:0019031 extrinsic component of intraperoxisomal membrane//trans-Golgi network//viral envelope KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.34956 BP_3 2747.02 93.95 1701 270010395 EFA06843.1 2157 8.4e-240 hypothetical protein TcasGA2_TC009786 [Tribolium castaneum] 752877329 XM_011257793.1 256 3.74343e-129 PREDICTED: Camponotus floridanus serine--tRNA ligase, cytoplasmic (LOC105251197), mRNA K01875 SARS, serS seryl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01875 P26638 1727 2.5e-191 Serine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Sars PE=2 SV=3 PF00587 tRNA synthetase class II core domain (G, H, P, S and T) GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//ATP binding//nucleotide binding -- -- KOG2509 Seryl-tRNA synthetase Cluster-8309.34958 BP_3 305.59 9.18 1896 91083955 XP_975011.1 1667 6.2e-183 PREDICTED: prolactin regulatory element-binding protein isoform X1 [Tribolium castaneum]>gi|270007977|gb|EFA04425.1| hypothetical protein TcasGA2_TC014725 [Tribolium castaneum] -- -- -- -- -- K14003 PREB, SEC12 prolactin regulatory element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14003 Q9HCU5 487 1.7e-47 Prolactin regulatory element-binding protein OS=Homo sapiens GN=PREB PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p Cluster-8309.3496 BP_3 21.14 1.32 1064 642929979 XP_008196051.1 516 1.0e-49 PREDICTED: centromere-associated protein E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34963 BP_3 1455.32 14.30 5197 642932227 XP_008194631.1 501 2.7e-47 PREDICTED: transforming growth factor beta-1-induced transcript 1 protein-like isoform X4 [Tribolium castaneum] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 247 3.2e-19 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF01853//PF01258//PF00412 MOZ/SAS family//Prokaryotic dksA/traR C4-type zinc finger//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0016747//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.34966 BP_3 135.05 1.63 4293 270016407 EFA12853.1 2602 5.3e-291 hypothetical protein TcasGA2_TC000150 [Tribolium castaneum] -- -- -- -- -- K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 O76083 900 5.0e-95 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens GN=PDE9A PE=1 SV=1 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.3497 BP_3 51.83 0.49 5410 642929979 XP_008196051.1 1148 2.7e-122 PREDICTED: centromere-associated protein E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34972 BP_3 170.71 5.24 1863 568599616 AHE13803.1 391 5.5e-35 chemosensory protein 8 [Lissorhoptrus oryzophilus] 329762923 HQ587041.1 381 0 Batocera horsfieldi chemosensory protein (CSP2) mRNA, complete cds -- -- -- -- Q9W1C9 295 3.1e-25 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF00660 Seripauperin and TIP1 family GO:0006950 response to stress -- -- -- -- -- -- Cluster-8309.34973 BP_3 20.00 0.59 1915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34974 BP_3 50.62 0.83 3245 91079134 XP_975446.1 995 8.9e-105 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|642916464|ref|XP_008191038.1| PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270004224|gb|EFA00672.1| hypothetical protein TcasGA2_TC003549 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 P80034 579 6.3e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 PF03446//PF01408 NAD binding domain of 6-phosphogluconate dehydrogenase//Oxidoreductase family, NAD-binding Rossmann fold GO:0006525//GO:0006098//GO:0055129//GO:0006561//GO:0019521//GO:0055114 arginine metabolic process//pentose-phosphate shunt//L-proline biosynthetic process//proline biosynthetic process//D-gluconate metabolic process//oxidation-reduction process GO:0004735//GO:0016491//GO:0000166//GO:0004616 pyrroline-5-carboxylate reductase activity//oxidoreductase activity//nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.34976 BP_3 9.00 0.91 767 817061123 XP_012252151.1 183 3.0e-11 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.34977 BP_3 385.35 4.45 4461 91085615 XP_969560.1 283 4.4e-22 PREDICTED: ubiquitin-conjugating enzyme E2 R2 [Tribolium castaneum]>gi|270010080|gb|EFA06528.1| hypothetical protein TcasGA2_TC009432 [Tribolium castaneum] 332372777 BT126567.1 86 3.1612e-34 Dendroctonus ponderosae clone DPO1125_N09 unknown mRNA -- -- -- -- Q712K3 135 2.6e-06 Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens GN=UBE2R2 PE=1 SV=1 PF06524 NOA36 protein -- -- GO:0016874//GO:0000166//GO:0008270 ligase activity//nucleotide binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.34979 BP_3 21.84 0.71 1780 307201205 EFN81111.1 925 6.3e-97 Tubulin beta-1 chain [Harpegnathos saltator] 164683615 EU373305.1 452 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 923 4.5e-98 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 PF00091//PF04816 Tubulin/FtsZ family, GTPase domain//tRNA (adenine(22)-N(1))-methyltransferase GO:0009451//GO:0008033 RNA modification//tRNA processing GO:0003924//GO:0016429 GTPase activity//tRNA (adenine-N1-)-methyltransferase activity -- -- KOG1375 Beta tubulin Cluster-8309.34980 BP_3 804.00 13.76 3108 91082745 XP_973149.1 1238 5.6e-133 PREDICTED: soluble NSF attachment protein [Tribolium castaneum]>gi|270014950|gb|EFA11398.1| hypothetical protein TcasGA2_TC013571 [Tribolium castaneum] -- -- -- -- -- K15296 NAPA, SNAPA, SEC17 alpha-soluble NSF attachment protein http://www.genome.jp/dbget-bin/www_bget?ko:K15296 Q23983 1032 1.8e-110 Soluble NSF attachment protein OS=Drosophila melanogaster GN=Snap PE=1 SV=1 PF13176//PF09204//PF13414//PF13174//PF13181//PF00515//PF02609 Tetratricopeptide repeat//Bacterial self-protective colicin-like immunity//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Exonuclease VII small subunit GO:0006308//GO:0006955//GO:0030153//GO:0006886 DNA catabolic process//immune response//bacteriocin immunity//intracellular protein transport GO:0015643//GO:0008855//GO:0005515 toxic substance binding//exodeoxyribonuclease VII activity//protein binding GO:0009318//GO:0005622//GO:0019814 exodeoxyribonuclease VII complex//intracellular//immunoglobulin complex KOG1586 Protein required for fusion of vesicles in vesicular transport, alpha-SNAP Cluster-8309.34981 BP_3 3470.00 184.55 1198 -- -- -- -- -- 462332881 APGK01039173.1 34 6.7034e-06 Dendroctonus ponderosae Seq01039183, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34985 BP_3 606.00 63.74 750 91082035 XP_970659.1 811 4.4e-84 PREDICTED: transmembrane and coiled-coil domain-containing protein 1 [Tribolium castaneum]>gi|270007385|gb|EFA03833.1| hypothetical protein TcasGA2_TC013949 [Tribolium castaneum] 805816325 XM_003706745.2 194 4.7017e-95 PREDICTED: Megachile rotundata transmembrane and coiled-coil domain-containing protein 1 (LOC100881658), mRNA -- -- -- -- Q3T0N3 623 1.2e-63 Transmembrane and coiled-coil domain-containing protein 1 OS=Bos taurus GN=TMCO1 PE=2 SV=1 PF01733//PF02601//PF01956//PF00558//PF02096 Nucleoside transporter//Exonuclease VII, large subunit//Integral membrane protein DUF106//Vpu protein//60Kd inner membrane protein GO:0015858//GO:0051205//GO:0019076//GO:0006810//GO:0006812//GO:0006308//GO:0032801 nucleoside transport//protein insertion into membrane//viral release from host cell//transport//cation transport//DNA catabolic process//receptor catabolic process GO:0005261//GO:0008855//GO:0005337 cation channel activity//exodeoxyribonuclease VII activity//nucleoside transmembrane transporter activity GO:0016021//GO:0009318//GO:0016020//GO:0033644 integral component of membrane//exodeoxyribonuclease VII complex//membrane//host cell membrane KOG3312 Predicted membrane protein Cluster-8309.34986 BP_3 2825.00 176.09 1065 769865040 XP_011644434.1 1793 8.5e-198 PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus]>gi|769865042|ref|XP_011644435.1| PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus]>gi|769865044|ref|XP_011644436.1| PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus]>gi|769865046|ref|XP_011644437.1| PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus] 410810328 HE962191.1 501 0 Phaedon cochleariae mRNA for elongation factor 1 alpha (ef1alpha gene) K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P05303 1772 9.5e-197 Elongation factor 1-alpha 2 OS=Drosophila melanogaster GN=Ef1alpha100E PE=2 SV=2 PF04670//PF01926//PF03144 Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.34987 BP_3 17.00 2.59 608 328899696 AEB54645.1 674 2.8e-68 ribosomal protein L9 [Procambarus clarkii] 262401370 FJ774867.1 286 2.71478e-146 Scylla paramamosain RPL9 protein-like protein mRNA, partial cds K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 P50882 537 8.7e-54 60S ribosomal protein L9 OS=Drosophila melanogaster GN=RpL9 PE=1 SV=2 PF00347//PF15510 Ribosomal protein L6//Centromere kinetochore component W GO:0006412//GO:0051382//GO:0042254//GO:0007067 translation//kinetochore assembly//ribosome biogenesis//mitotic nuclear division GO:0003677//GO:0019843//GO:0003735 DNA binding//rRNA binding//structural constituent of ribosome GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-8309.34988 BP_3 345.19 3.45 5113 91094587 XP_970350.1 3321 0.0e+00 PREDICTED: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [Tribolium castaneum] 642939259 XM_965257.2 500 0 PREDICTED: Tribolium castaneum high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (LOC658906), mRNA K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 O70628 911 3.2e-96 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Mus musculus GN=Pde9a PE=1 SV=1 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.34990 BP_3 90.85 1.43 3348 642933488 XP_008197439.1 1228 8.8e-132 PREDICTED: solute carrier family 25 member 38-A isoform X1 [Tribolium castaneum] -- -- -- -- -- K15118 SLC25A38 solute carrier family 25, member 38 http://www.genome.jp/dbget-bin/www_bget?ko:K15118 Q08CI8 776 9.3e-81 Solute carrier family 25 member 38-A OS=Danio rerio GN=slc25a38a PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0766 Predicted mitochondrial carrier protein Cluster-8309.34991 BP_3 355.25 10.29 1956 642933488 XP_008197439.1 1259 1.3e-135 PREDICTED: solute carrier family 25 member 38-A isoform X1 [Tribolium castaneum] -- -- -- -- -- K15118 SLC25A38 solute carrier family 25, member 38 http://www.genome.jp/dbget-bin/www_bget?ko:K15118 Q08CI8 776 5.4e-81 Solute carrier family 25 member 38-A OS=Danio rerio GN=slc25a38a PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0766 Predicted mitochondrial carrier protein Cluster-8309.34993 BP_3 11330.00 1127.67 776 91080583 XP_973590.1 661 1.1e-66 PREDICTED: 60S ribosomal protein L27a [Tribolium castaneum]>gi|270005809|gb|EFA02257.1| hypothetical protein TcasGA2_TC007920 [Tribolium castaneum] 70909818 AM049096.1 177 1.37402e-85 Agriotes lineatus mRNA for ribosomal protein L27Ae (rpL27Ae gene) K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 Q27021 563 1.1e-56 60S ribosomal protein L27a OS=Tenebrio molitor GN=RpL27A PE=2 SV=1 -- -- GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1742 60s ribosomal protein L15/L27 Cluster-8309.34994 BP_3 16.43 0.34 2630 642921394 XP_008192849.1 1690 1.8e-185 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270006281|gb|EFA02729.1| hypothetical protein TcasGA2_TC008454 [Tribolium castaneum] -- -- -- -- -- K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 P45844 984 5.6e-105 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF01061 ABC-2 type transporter GO:0006200 obsolete ATP catabolic process GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.34995 BP_3 690.91 24.87 1631 478254720 ENN74961.1 2325 2.7e-259 hypothetical protein YQE_08537, partial [Dendroctonus ponderosae]>gi|546682080|gb|ERL92066.1| hypothetical protein D910_09388 [Dendroctonus ponderosae] -- -- -- -- -- K10599 PRPF19, PRP19 pre-mRNA-processing factor 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10599 Q9UMS4 1726 3.1e-191 Pre-mRNA-processing factor 19 OS=Homo sapiens GN=PRPF19 PE=1 SV=1 PF00400//PF04564//PF11716//PF11789 WD domain, G-beta repeat//U-box domain//Mycothiol maleylpyruvate isomerase N-terminal domain//Zinc-finger of the MIZ type in Nse subunit GO:0016567 protein ubiquitination GO:0005515//GO:0046872//GO:0004842//GO:0008270 protein binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding -- -- KOG0289 mRNA splicing factor Cluster-8309.34998 BP_3 243.15 9.57 1516 642912278 XP_967486.2 591 2.9e-58 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] 224922973 AC235209.1 34 8.53631e-06 Glycine max strain Williams 82 clone GM_WBb0018O23, complete sequence K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 P98164 194 1.3e-13 Low-density lipoprotein receptor-related protein 2 OS=Homo sapiens GN=LRP2 PE=1 SV=3 PF00089//PF05460//PF00057 Trypsin//Origin recognition complex subunit 6 (ORC6)//Low-density lipoprotein receptor domain class A GO:0006260//GO:0006508 DNA replication//proteolysis GO:0003677//GO:0004252//GO:0005515 DNA binding//serine-type endopeptidase activity//protein binding GO:0005664 nuclear origin of replication recognition complex -- -- Cluster-8309.34999 BP_3 1423.05 17.05 4314 270002885 EEZ99332.1 703 8.5e-71 serine protease P46 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75096 311 1.0e-26 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF03875//PF00057//PF07415//PF00089 Statherin//Low-density lipoprotein receptor domain class A//Gammaherpesvirus latent membrane protein (LMP2) protein//Trypsin GO:0030500//GO:0042742//GO:0006508//GO:0019042 regulation of bone mineralization//defense response to bacterium//proteolysis//viral latency GO:0005515//GO:0046848//GO:0004252 protein binding//hydroxyapatite binding//serine-type endopeptidase activity GO:0033644//GO:0005576 host cell membrane//extracellular region KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.350 BP_3 2.00 0.40 533 646696618 KDR08794.1 547 1.3e-53 Transient receptor potential cation channel subfamily A member 1 [Zootermopsis nevadensis] -- -- -- -- -- K04984 TRPA1, ANKTM1 transient receptor potential cation channel subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04984 Q7Z020 519 9.4e-52 Transient receptor potential cation channel subfamily A member 1 OS=Drosophila melanogaster GN=TrpA1 PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3500 BP_3 6.00 0.45 928 607355113 EZA49708.1 210 2.7e-14 hypothetical protein X777_11794 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35000 BP_3 701.73 24.79 1656 646714971 KDR18744.1 1884 3.7e-208 26S protease regulatory subunit 6B [Zootermopsis nevadensis] 194762611 XM_001963392.1 392 0 Drosophila ananassae GF20295 (Dana\GF20295), mRNA K03063 PSMC4, RPT3 26S proteasome regulatory subunit T3 http://www.genome.jp/dbget-bin/www_bget?ko:K03063 P46507 1866 1.9e-207 26S protease regulatory subunit 6B OS=Manduca sexta PE=2 SV=1 PF01695//PF07728//PF01057//PF00158//PF00004//PF06414//PF02367//PF00931//PF05496//PF06068//PF07724//PF00005//PF03266//PF07726//PF01637//PF00910 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//AAA domain (Cdc48 subfamily)//ABC transporter//NTPase//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//RNA helicase GO:0019079//GO:0006281//GO:0006355//GO:0006310//GO:0002949 viral genome replication//DNA repair//regulation of transcription, DNA-templated//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0098519//GO:0008134//GO:0016887//GO:0016301//GO:0003723//GO:0003678//GO:0043531//GO:0003724//GO:0009378 ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//ATPase activity//kinase activity//RNA binding//DNA helicase activity//ADP binding//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0727 26S proteasome regulatory complex, ATPase RPT3 Cluster-8309.35001 BP_3 533.75 2.82 9413 546672491 ERL84327.1 5266 0.0e+00 hypothetical protein D910_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 764 6.5e-79 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF02480//PF13895 Alphaherpesvirus glycoprotein E//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.35003 BP_3 2563.74 90.78 1653 91079342 XP_969395.1 573 3.9e-56 PREDICTED: chromobox protein homolog 1 [Tribolium castaneum]>gi|270004356|gb|EFA00804.1| hypothetical protein TcasGA2_TC003691 [Tribolium castaneum] -- -- -- -- -- K11587 CBX5, HP1A chromobox protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11587 P45973 162 7.2e-10 Chromobox protein homolog 5 OS=Homo sapiens GN=CBX5 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.35004 BP_3 13669.90 714.42 1214 642936067 XP_008198289.1 667 3.6e-67 PREDICTED: 60S ribosomal protein L23a-like [Tribolium castaneum]>gi|270014014|gb|EFA10462.1| hypothetical protein TcasGA2_TC012708 [Tribolium castaneum] 807017617 XM_004518966.2 104 8.30698e-45 PREDICTED: Ceratitis capitata 60S ribosomal protein L23a (LOC101463395), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 486 1.4e-47 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0000166//GO:0003735 nucleotide binding//structural constituent of ribosome GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.35005 BP_3 343.33 1.60 10620 817185266 XP_012285919.1 6598 0.0e+00 PREDICTED: neurobeachin isoform X10 [Orussus abietinus] 642919353 XM_008193614.1 1061 0 PREDICTED: Tribolium castaneum neurobeachin (LOC662147), transcript variant X2, mRNA -- -- -- -- Q9W4E2 4768 0.0e+00 Neurobeachin OS=Drosophila melanogaster GN=rg PE=1 SV=3 PF15088//PF10508//PF07127//PF00400 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial//Proteasome non-ATPase 26S subunit//Late nodulin protein//WD domain, G-beta repeat GO:0009878//GO:0043248 nodule morphogenesis//proteasome assembly GO:0046872//GO:0005515 metal ion binding//protein binding GO:0005747//GO:0005739 mitochondrial respiratory chain complex I//mitochondrion KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.35006 BP_3 2010.00 48.60 2285 91078330 XP_973321.1 650 6.3e-65 PREDICTED: 15 kDa selenoprotein [Tribolium castaneum]>gi|270003970|gb|EFA00418.1| hypothetical protein TcasGA2_TC003269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z623 364 3.8e-33 15 kDa selenoprotein OS=Sus scrofa GN=SEP15 PE=2 SV=2 PF00096//PF02724 Zinc finger, C2H2 type//CDC45-like protein GO:0006270 DNA replication initiation GO:0046872 metal ion binding -- -- KOG2186 Cell growth-regulating nucleolar protein Cluster-8309.35007 BP_3 501.05 7.41 3550 91076582 XP_967875.1 1990 4.1e-220 PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912638|ref|XP_008200944.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912640|ref|XP_008200945.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|270002383|gb|EEZ98830.1| hypothetical protein TcasGA2_TC004437 [Tribolium castaneum] 751777425 XM_011199416.1 237 2.8794e-118 PREDICTED: Bactrocera dorsalis probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (LOC105222196), transcript variant X2, mRNA K00602 purH phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K00602 P31335 1697 1.6e-187 Bifunctional purine biosynthesis protein PURH OS=Gallus gallus GN=ATIC PE=1 SV=1 PF01808//PF00180 AICARFT/IMPCHase bienzyme//Isocitrate/isopropylmalate dehydrogenase GO:0006164//GO:0006144//GO:0055114//GO:0006807 purine nucleotide biosynthetic process//purine nucleobase metabolic process//oxidation-reduction process//nitrogen compound metabolic process GO:0016616//GO:0003937//GO:0004643 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//IMP cyclohydrolase activity//phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG2555 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase Cluster-8309.35009 BP_3 479.04 12.39 2155 91094127 XP_968492.1 2115 7.9e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 3.4e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0008235//GO:0004177//GO:0030145 metalloexopeptidase activity//aminopeptidase activity//manganese ion binding GO:0005622//GO:0005737 intracellular//cytoplasm KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.35011 BP_3 483.45 5.01 4940 478258110 ENN78248.1 2446 7.5e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 3.99005e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 2.9e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF01433//PF09127//PF08063//PF00400//PF01435 Peptidase family M1//Leukotriene A4 hydrolase, C-terminal//PADR1 (NUC008) domain//WD domain, G-beta repeat//Peptidase family M48 GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0005515//GO:0004222//GO:0003950//GO:0008270//GO:0008237 protein binding//metalloendopeptidase activity//NAD+ ADP-ribosyltransferase activity//zinc ion binding//metallopeptidase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.35015 BP_3 921.03 9.12 5162 642919377 XP_008191846.1 3550 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 831 6.0e-87 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF07714//PF00069//PF01325//PF13895//PF02480 Protein tyrosine kinase//Protein kinase domain//Iron dependent repressor, N-terminal DNA binding domain//Immunoglobulin domain//Alphaherpesvirus glycoprotein E GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0003677 protein binding//protein kinase activity//ATP binding//DNA binding GO:0016020 membrane -- -- Cluster-8309.35016 BP_3 489.00 8.48 3072 642923339 XP_008193708.1 3006 0.0e+00 PREDICTED: rab3 GTPase-activating protein catalytic subunit [Tribolium castaneum] -- -- -- -- -- K18270 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K18270 Q15042 1544 7.5e-170 Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens GN=RAB3GAP1 PE=1 SV=3 PF02025//PF13890 Interleukin 5//Rab3 GTPase-activating protein catalytic subunit GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0005137//GO:0005096//GO:0008083 interleukin-5 receptor binding//GTPase activator activity//growth factor activity GO:0005576//GO:0005895 extracellular region//interleukin-5 receptor complex KOG2390 Uncharacterized conserved protein Cluster-8309.35017 BP_3 44.00 18.52 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35018 BP_3 1705.04 53.15 1838 642938919 XP_008195595.1 932 1.0e-97 PREDICTED: suppressor protein SRP40-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03884 Domain of unknown function (DUF329) -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.35019 BP_3 605.00 7.48 4188 91080143 XP_968598.1 3802 0.0e+00 PREDICTED: transient-receptor-potential-like protein [Tribolium castaneum]>gi|270006411|gb|EFA02859.1| TRP gamma [Tribolium castaneum] 826443874 XM_012675413.1 168 7.73832e-80 PREDICTED: Monomorium pharaonis transient-receptor-potential-like protein (LOC105833576), transcript variant X2, mRNA K13803 TRPL transient-receptor-potential-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K13803 P48994 2688 2.3e-302 Transient-receptor-potential-like protein OS=Drosophila melanogaster GN=trpl PE=1 SV=2 PF00520//PF13606 Ion transport protein//Ankyrin repeat GO:0070588//GO:0055085//GO:0006816//GO:0006811 calcium ion transmembrane transport//transmembrane transport//calcium ion transport//ion transport GO:0005515//GO:0005262//GO:0005216 protein binding//calcium channel activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3609 Receptor-activated Ca2+-permeable cation channels (STRPC family) Cluster-8309.35020 BP_3 410.05 9.73 2323 91087969 XP_973121.1 1160 4.7e-124 PREDICTED: mitochondrial import inner membrane translocase subunit TIM50-C [Tribolium castaneum]>gi|270012048|gb|EFA08496.1| hypothetical protein TcasGA2_TC006148 [Tribolium castaneum] -- -- -- -- -- K17496 TIM50 mitochondrial import inner membrane translocase subunit TIM50 http://www.genome.jp/dbget-bin/www_bget?ko:K17496 Q9W4V8 812 4.3e-85 Mitochondrial import inner membrane translocase subunit TIM50-C OS=Drosophila melanogaster GN=ttm50 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2832 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.35022 BP_3 176.35 6.61 1578 91092934 XP_971990.1 855 7.4e-89 PREDICTED: mitochondrial import inner membrane translocase subunit Tim23 isoform X2 [Tribolium castaneum]>gi|270003027|gb|EEZ99474.1| hypothetical protein TcasGA2_TC000047 [Tribolium castaneum] -- -- -- -- -- K17794 TIM23 mitochondrial import inner membrane translocase subunit TIM23 http://www.genome.jp/dbget-bin/www_bget?ko:K17794 Q9WTQ8 390 2.5e-36 Mitochondrial import inner membrane translocase subunit Tim23 OS=Mus musculus GN=Timm23 PE=2 SV=1 -- -- -- -- -- -- GO:0016021 integral component of membrane KOG3324 Mitochondrial import inner membrane translocase, subunit TIM23 Cluster-8309.35024 BP_3 67.34 1.56 2376 91086235 XP_966692.1 2970 0.0e+00 PREDICTED: transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum]>gi|270011017|gb|EFA07465.1| transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum] 817081112 XM_012407627.1 599 0 PREDICTED: Athalia rosae transitional endoplasmic reticulum ATPase TER94 (LOC105690094), transcript variant X2, mRNA K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q7KN62 2819 0.0e+00 Transitional endoplasmic reticulum ATPase TER94 OS=Drosophila melanogaster GN=TER94 PE=1 SV=1 PF00931//PF03152//PF02562//PF02367//PF06414//PF00004//PF01057//PF00158//PF01695//PF07728//PF00910//PF02456//PF01637//PF04851//PF00005//PF07726//PF03266//PF07724//PF00437//PF01443//PF05496//PF06068//PF14532 NB-ARC domain//Ubiquitin fusion degradation protein UFD1//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//RNA helicase//Adenovirus IVa2 protein//Archaeal ATPase//Type III restriction enzyme, res subunit//ABC transporter//ATPase family associated with various cellular activities (AAA)//NTPase//AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//Sigma-54 interaction domain GO:0006310//GO:0006511//GO:0002949//GO:0019083//GO:0019079//GO:0006281//GO:0006810//GO:0006355 DNA recombination//ubiquitin-dependent protein catabolic process//tRNA threonylcarbamoyladenosine modification//viral transcription//viral genome replication//DNA repair//transport//regulation of transcription, DNA-templated GO:0003677//GO:0003723//GO:0003678//GO:0043531//GO:0003724//GO:0017111//GO:0009378//GO:0016787//GO:0098519//GO:0005524//GO:0008134//GO:0016887//GO:0016301 DNA binding//RNA binding//DNA helicase activity//ADP binding//RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//hydrolase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//transcription factor binding//ATPase activity//kinase activity GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0730 AAA+-type ATPase Cluster-8309.35025 BP_3 12.19 0.50 1463 808884880 KKF31755.1 178 2.2e-10 Elongation factor 1-alpha [Larimichthys crocea] 196014369 XM_002117008.1 66 1.33888e-23 Trichoplax adhaerens elongation factor 1 alpha, mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q9YIC0 176 1.5e-11 Elongation factor 1-alpha OS=Oryzias latipes GN=eef1a PE=2 SV=1 PF00503//PF01580 G-protein alpha subunit//FtsK/SpoIIIE family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0000166//GO:0004871//GO:0019001//GO:0005524//GO:0003677//GO:0031683//GO:0003924 nucleotide binding//signal transducer activity//guanyl nucleotide binding//ATP binding//DNA binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.35026 BP_3 193.42 7.24 1580 91093173 XP_967937.1 401 3.3e-36 PREDICTED: 40S ribosomal protein S21 [Tribolium castaneum]>gi|270012942|gb|EFA09390.1| hypothetical protein TcasGA2_TC004308 [Tribolium castaneum] 645004566 XM_001604620.3 87 3.06977e-35 PREDICTED: Nasonia vitripennis 40S ribosomal protein S21 (LOC100114107), mRNA K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q4GXP2 393 1.1e-36 40S ribosomal protein S21 OS=Biphyllus lunatus GN=RpS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-8309.35027 BP_3 192.00 5.01 2140 815907605 XP_012239531.1 192 7.6e-12 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01022 Bacterial regulatory protein, arsR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.35028 BP_3 7.00 1.34 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35029 BP_3 11.58 0.35 1907 332372941 AEE61612.1 1001 1.0e-105 unknown [Dendroctonus ponderosae] 642917730 XM_008193127.1 149 1.27313e-69 PREDICTED: Tribolium castaneum glutamine synthetase 2 cytoplasmic (LOC656087), transcript variant X4, mRNA K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 P20478 834 1.0e-87 Glutamine synthetase 2 cytoplasmic OS=Drosophila melanogaster GN=Gs2 PE=2 SV=3 PF03951//PF01844//PF00120 Glutamine synthetase, beta-Grasp domain//HNH endonuclease//Glutamine synthetase, catalytic domain GO:0006542//GO:0009252//GO:0006807 glutamine biosynthetic process//peptidoglycan biosynthetic process//nitrogen compound metabolic process GO:0003676//GO:0004356//GO:0004519 nucleic acid binding//glutamate-ammonia ligase activity//endonuclease activity -- -- KOG0683 Glutamine synthetase Cluster-8309.35030 BP_3 122.00 4.46 1610 642922960 XP_008200469.1 284 1.2e-22 PREDICTED: uncharacterized protein LOC100142444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35031 BP_3 225.58 4.19 2888 270009512 EFA05960.1 1547 7.7e-169 hypothetical protein TcasGA2_TC008778 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P20060 1183 5.1e-128 Beta-hexosaminidase subunit beta OS=Mus musculus GN=Hexb PE=2 SV=2 PF08085//PF00728//PF09328//PF08013 Entericidin EcnA/B family//Glycosyl hydrolase family 20, catalytic domain//Domain of unknown function (DUF1984)//Tagatose 6 phosphate kinase GO:0005975//GO:0046938//GO:0010038//GO:0019402//GO:0009636 carbohydrate metabolic process//phytochelatin biosynthetic process//response to metal ion//galactitol metabolic process//response to toxic substance GO:0046872//GO:0016756//GO:0004553 metal ion binding//glutathione gamma-glutamylcysteinyltransferase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016020 membrane KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.35033 BP_3 281.27 1.05 13172 642918534 XP_008191512.1 3762 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.80773e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1207 3.9e-130 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02383//PF13895//PF05461 SacI homology domain//Immunoglobulin domain//Apolipoprotein L GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0042578//GO:0008289 protein binding//phosphoric ester hydrolase activity//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.35035 BP_3 1050.00 23.79 2419 189235234 XP_001812254.1 2120 2.3e-235 PREDICTED: SRSF protein kinase 1 [Tribolium castaneum]>gi|270003734|gb|EFA00182.1| hypothetical protein TcasGA2_TC003007 [Tribolium castaneum] 462288448 APGK01055188.1 316 2.37184e-162 Dendroctonus ponderosae Seq01055198, whole genome shotgun sequence K15409 SRPK1 serine/threonine-protein kinase SRPK1 http://www.genome.jp/dbget-bin/www_bget?ko:K15409 Q03563 1217 4.9e-132 Serine/threonine-protein kinase spk-1 OS=Caenorhabditis elegans GN=spk-1 PE=2 SV=3 PF00069//PF07714//PF09201//PF01233 Protein kinase domain//Protein tyrosine kinase//SRX, signal recognition particle receptor alpha subunit//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain GO:0006468//GO:0009069//GO:0016310//GO:0042967 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//acyl-carrier-protein biosynthetic process GO:0004674//GO:0004672//GO:0004379//GO:0005515//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//glycylpeptide N-tetradecanoyltransferase activity//protein binding//ATP binding -- -- KOG1290 Serine/threonine protein kinase Cluster-8309.35036 BP_3 1670.00 20.95 4134 91076582 XP_967875.1 2548 9.4e-285 PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912638|ref|XP_008200944.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912640|ref|XP_008200945.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|270002383|gb|EEZ98830.1| hypothetical protein TcasGA2_TC004437 [Tribolium castaneum] 751777425 XM_011199416.1 237 3.35794e-118 PREDICTED: Bactrocera dorsalis probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (LOC105222196), transcript variant X2, mRNA K00602 purH phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K00602 P31335 2131 8.7e-238 Bifunctional purine biosynthesis protein PURH OS=Gallus gallus GN=ATIC PE=1 SV=1 PF00180//PF01808 Isocitrate/isopropylmalate dehydrogenase//AICARFT/IMPCHase bienzyme GO:0006807//GO:0055114//GO:0006164//GO:0006144 nitrogen compound metabolic process//oxidation-reduction process//purine nucleotide biosynthetic process//purine nucleobase metabolic process GO:0003937//GO:0004643//GO:0016616 IMP cyclohydrolase activity//phosphoribosylaminoimidazolecarboxamide formyltransferase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0042720 mitochondrial inner membrane peptidase complex KOG2555 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase Cluster-8309.35037 BP_3 94.54 2.19 2375 546680705 ERL90931.1 2504 6.8e-280 hypothetical protein D910_08274, partial [Dendroctonus ponderosae] 642930215 XM_965099.2 283 5.14747e-144 PREDICTED: Tribolium castaneum protein UBASH3A homolog (LOC658737), transcript variant X1, mRNA K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 1265 1.3e-137 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.35038 BP_3 424.95 5.03 4366 642926721 XP_008194985.1 1671 4.9e-183 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 552 1.1e-54 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.35039 BP_3 1733.54 71.03 1468 642926721 XP_008194985.1 1279 4.7e-138 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4J913 413 5.0e-39 Facilitated trehalose transporter Tret1 OS=Drosophila grimshawi GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.3504 BP_3 25.89 1.78 992 478251152 ENN71628.1 591 1.9e-58 hypothetical protein YQE_11727, partial [Dendroctonus ponderosae]>gi|546685814|gb|ERL95257.1| hypothetical protein D910_12524 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A0JNG4 276 2.6e-23 RING finger protein 207 OS=Bos taurus GN=RNF207 PE=2 SV=1 PF00097//PF00643//PF14634//PF13639//PF16685 Zinc finger, C3HC4 type (RING finger)//B-box zinc finger//zinc-RING finger domain//Ring finger domain//zinc RING finger of MSL2 -- -- GO:0008270//GO:0061630//GO:0005515//GO:0046872 zinc ion binding//ubiquitin protein ligase activity//protein binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.35040 BP_3 102.88 1.73 3156 642918440 XP_008191474.1 1171 3.4e-125 PREDICTED: band 7 protein AGAP004871 isoform X3 [Tribolium castaneum] 157115716 XM_001658225.1 192 2.64861e-93 Aedes aegypti AAEL007320-RA partial mRNA K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q7PPU9 967 6.3e-103 Band 7 protein AGAP004871 OS=Anopheles gambiae GN=AGAP004871 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.35041 BP_3 20.97 0.53 2197 817079106 XP_012261949.1 591 4.2e-58 PREDICTED: nascent polypeptide-associated complex subunit alpha [Athalia rosae]>gi|817079108|ref|XP_012261950.1| PREDICTED: nascent polypeptide-associated complex subunit alpha [Athalia rosae] 346709586 AK384066.1 60 4.38784e-20 Bombyx mori mRNA, clone: fcaL06G10 K03626 EGD2, NACA nascent polypeptide-associated complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03626 Q94518 536 4.1e-53 Nascent polypeptide-associated complex subunit alpha OS=Drosophila melanogaster GN=Nacalpha PE=1 SV=2 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG2239 Transcription factor containing NAC and TS-N domains Cluster-8309.35043 BP_3 311.71 15.23 1278 478250485 ENN70980.1 1257 1.5e-135 hypothetical protein YQE_12380, partial [Dendroctonus ponderosae] 157115716 XM_001658225.1 214 6.21924e-106 Aedes aegypti AAEL007320-RA partial mRNA K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q7PPU9 1044 3.0e-112 Band 7 protein AGAP004871 OS=Anopheles gambiae GN=AGAP004871 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.35044 BP_3 156.58 1.62 4962 478250485 ENN70980.1 1238 9.0e-133 hypothetical protein YQE_12380, partial [Dendroctonus ponderosae] 157115716 XM_001658225.1 210 4.12299e-103 Aedes aegypti AAEL007320-RA partial mRNA K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q7PPU9 1036 9.8e-111 Band 7 protein AGAP004871 OS=Anopheles gambiae GN=AGAP004871 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.35045 BP_3 47.00 3.52 936 780089478 XP_011673857.1 278 3.5e-22 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q8N8A2 220 7.7e-17 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens GN=ANKRD44 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35047 BP_3 4.29 0.48 721 91080615 XP_974171.1 778 2.9e-80 PREDICTED: 60S ribosomal protein L21 [Tribolium castaneum]>gi|270005820|gb|EFA02268.1| hypothetical protein TcasGA2_TC007932 [Tribolium castaneum] -- -- -- -- -- K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 P46778 571 1.2e-57 60S ribosomal protein L21 OS=Homo sapiens GN=RPL21 PE=1 SV=2 PF01157 Ribosomal protein L21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.35048 BP_3 486.78 15.32 1823 91092778 XP_973837.1 667 5.4e-67 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.35050 BP_3 212.33 3.39 3315 91078902 XP_973455.1 765 4.2e-78 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q3ZBT5 352 1.4e-31 Syntaxin-7 OS=Bos taurus GN=STX7 PE=2 SV=1 PF01829//PF08597//PF04632//PF02561//PF05531 Peptidase A6 family//Translation initiation factor eIF3 subunit//Fusaric acid resistance protein family//Flagellar protein FliS//Nucleopolyhedrovirus P10 protein GO:0006508//GO:0006810//GO:0006446 proteolysis//transport//regulation of translational initiation GO:0004190//GO:0003743 aspartic-type endopeptidase activity//translation initiation factor activity GO:0005840//GO:0009288//GO:0005737//GO:0005852//GO:0005886//GO:0019028 ribosome//bacterial-type flagellum//cytoplasm//eukaryotic translation initiation factor 3 complex//plasma membrane//viral capsid KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.35051 BP_3 430.78 11.84 2046 642930028 XP_008196218.1 696 2.6e-70 PREDICTED: homothorax isoform X2 [Tribolium castaneum] 642930027 XM_008197996.1 422 0 PREDICTED: Tribolium castaneum homothorax (Hth), transcript variant X2, mRNA K15613 MEIS1 homeobox protein Meis1 http://www.genome.jp/dbget-bin/www_bget?ko:K15613 O46339 557 1.4e-55 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 PF05920//PF05739//PF00046 Homeobox KN domain//SNARE domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.35052 BP_3 1393.00 17.51 4127 642938258 XP_008198133.1 2006 6.6e-222 PREDICTED: rab-like protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U3K5 754 4.1e-78 Rab-like protein 6 OS=Mus musculus GN=Rabl6 PE=1 SV=2 PF00025//PF00071//PF08477//PF09749//PF02724//PF01926 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//Uncharacterised conserved protein//CDC45-like protein//50S ribosome-binding GTPase GO:0007264//GO:0034477//GO:0006270 small GTPase mediated signal transduction//U6 snRNA 3'-end processing//DNA replication initiation GO:0005525//GO:0004518 GTP binding//nuclease activity -- -- -- -- Cluster-8309.35054 BP_3 35.06 0.55 3389 642913910 XP_008201210.1 214 3.4e-14 PREDICTED: uncharacterized protein LOC663390 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01290 Thymosin beta-4 family GO:0007015 actin filament organization GO:0003785 actin monomer binding -- -- -- -- Cluster-8309.35055 BP_3 4932.32 164.15 1740 642933037 XP_008197238.1 659 4.3e-66 PREDICTED: troponin C-like [Tribolium castaneum] 242006313 XM_002423952.1 34 9.82742e-06 Pediculus humanus corporis Troponin C, putative, mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P15159 435 1.7e-41 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF13499//PF13833//PF00036//PF13405//PF12763//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35056 BP_3 982.43 20.23 2632 642935906 XP_008198223.1 2244 1.1e-249 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 645001298 XM_008211242.1 690 0 PREDICTED: Nasonia vitripennis calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC100113791), transcript variant X6, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2094 1.1e-233 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF00122//PF09264 E1-E2 ATPase//Vibrio cholerae sialidase, lectin insertion -- -- GO:0046872//GO:0033691//GO:0000166 metal ion binding//sialic acid binding//nucleotide binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.35059 BP_3 117.19 0.79 7444 642934874 XP_008197845.1 2625 2.0e-293 PREDICTED: ecdysone-induced protein 75B, isoforms C/D isoform X4 [Tribolium castaneum] 443682249 KC020244.1 254 2.15159e-127 Monochamus alternatus ecdysone-induced protein 75-like protein (E75) mRNA, partial cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1308 4.2e-142 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4846 Nuclear receptor Cluster-8309.35060 BP_3 180.87 8.43 1326 642924915 XP_008194095.1 540 2.1e-52 PREDICTED: neprilysin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 O16796 329 2.5e-29 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.35061 BP_3 64.03 0.59 5485 270002665 EEZ99112.1 1144 7.9e-122 hypothetical protein TcasGA2_TC005005 [Tribolium castaneum] 817188844 XM_012433587.1 77 3.92037e-29 PREDICTED: Orussus abietinus RING finger protein 44 (LOC105704395), partial mRNA K19041 RNF38_44 E3 ubiquitin-protein ligase RNF38/44 http://www.genome.jp/dbget-bin/www_bget?ko:K19041 Q08CG8 412 2.5e-38 RING finger protein 44 OS=Danio rerio GN=rnf44 PE=2 SV=1 PF13639//PF12861//PF00287//PF12678//PF12906//PF17123//PF14634//PF00097 Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Sodium / potassium ATPase beta chain//RING-H2 zinc finger//RING-variant domain//RING-like zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) GO:0006814//GO:0006813//GO:0016567 sodium ion transport//potassium ion transport//protein ubiquitination GO:0046872//GO:0008270//GO:0004842//GO:0005515 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding GO:0005890//GO:0005680 sodium:potassium-exchanging ATPase complex//anaphase-promoting complex -- -- Cluster-8309.35062 BP_3 434.30 6.13 3708 91092348 XP_971306.1 1293 2.8e-139 PREDICTED: uncharacterized protein LOC659947 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0046813//GO:0061025 receptor-mediated virion attachment to host cell//membrane fusion -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-8309.35063 BP_3 193.01 3.41 3018 478250426 ENN70921.1 505 5.4e-48 hypothetical protein YQE_12323, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BLW3 163 1.0e-09 Leucine-rich repeat-containing G-protein coupled receptor 4 OS=Xenopus tropicalis GN=lgr4 PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.35064 BP_3 4103.31 370.18 826 264667363 ACY71267.1 534 6.4e-52 ribosomal protein S24 [Chrysomela tremula] 642917806 XM_962484.3 221 5.09154e-110 PREDICTED: Tribolium castaneum 40S ribosomal protein S24 (LOC655928), mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 Q962Q6 511 1.2e-50 40S ribosomal protein S24 OS=Spodoptera frugiperda GN=RpS24 PE=2 SV=1 PF01282 Ribosomal protein S24e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3424 40S ribosomal protein S24 Cluster-8309.35065 BP_3 2579.48 95.77 1590 642935906 XP_008198223.1 2248 2.2e-250 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 645001298 XM_008211242.1 690 0 PREDICTED: Nasonia vitripennis calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC100113791), transcript variant X6, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2098 2.2e-234 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF09264//PF00122 Vibrio cholerae sialidase, lectin insertion//E1-E2 ATPase -- -- GO:0000166//GO:0033691//GO:0046872 nucleotide binding//sialic acid binding//metal ion binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.35066 BP_3 51.54 2.18 1429 546680707 ERL90933.1 789 3.0e-81 hypothetical protein D910_08275 [Dendroctonus ponderosae] 27616447 BX043166.1 94 3.55764e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC15CD01 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K03521 fixA, etfB electron transfer flavoprotein beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03521 Q9DCW4 646 4.7e-66 Electron transfer flavoprotein subunit beta OS=Mus musculus GN=Etfb PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3180 Electron transfer flavoprotein, beta subunit Cluster-8309.35067 BP_3 1276.30 58.41 1345 478252371 ENN72797.1 853 1.1e-88 hypothetical protein YQE_10601, partial [Dendroctonus ponderosae] 27616447 BX043166.1 94 3.34326e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC15CD01 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K03521 fixA, etfB electron transfer flavoprotein beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03521 Q9DCW4 679 6.6e-70 Electron transfer flavoprotein subunit beta OS=Mus musculus GN=Etfb PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3180 Electron transfer flavoprotein, beta subunit Cluster-8309.35069 BP_3 1060.59 15.13 3670 189234829 XP_001811696.1 2732 3.8e-306 PREDICTED: protein fem-1 homolog CG6966 isoform X1 [Tribolium castaneum]>gi|270001481|gb|EEZ97928.1| hypothetical protein TcasGA2_TC000315 [Tribolium castaneum] 751210067 XM_011159412.1 147 3.19602e-68 PREDICTED: Solenopsis invicta protein fem-1 homolog CG6966 (LOC105194484), transcript variant X2, mRNA -- -- -- -- Q9VFD5 1696 2.1e-187 Protein fem-1 homolog CG6966 OS=Drosophila melanogaster GN=CG6966 PE=2 SV=2 PF13374//PF13606//PF00023 Tetratricopeptide repeat//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35071 BP_3 84.15 1.50 3004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35072 BP_3 446.40 3.92 5778 642924882 XP_008194082.1 2220 1.4e-246 PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|642924884|ref|XP_008194083.1| PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|270008015|gb|EFA04463.1| hypothetical protein TcasGA2_TC014767 [Tribolium castaneum] 795080210 XM_012021821.1 347 3.34119e-179 PREDICTED: Vollenhovia emeryi serine/threonine-protein kinase 25 (LOC105567182), transcript variant X6, mRNA K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 B0LT89 1090 6.3e-117 Serine/threonine-protein kinase 24 OS=Rattus norvegicus GN=Stk24 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0201 Serine/threonine protein kinase Cluster-8309.35074 BP_3 495.73 16.92 1704 546678022 ERL88746.1 1595 1.2e-174 hypothetical protein D910_06128 [Dendroctonus ponderosae] 642927752 XM_963523.2 171 6.68792e-82 PREDICTED: Tribolium castaneum probable UDP-glucose 4-epimerase (LOC657035), transcript variant X2, mRNA K01784 galE, GALE UDP-glucose 4-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01784 Q9W0P5 1177 1.5e-127 UDP-glucose 4-epimerase OS=Drosophila melanogaster GN=Gale PE=1 SV=1 PF00106//PF01073//PF01370//PF03435//PF02254 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//TrkA-N domain GO:0008210//GO:0008152//GO:0006813//GO:0008207//GO:0008209//GO:0055114//GO:0006694 estrogen metabolic process//metabolic process//potassium ion transport//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0050662//GO:0003824//GO:0003854//GO:0016491//GO:0016616 coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase Cluster-8309.35075 BP_3 44.41 1.07 2299 571330970 AHF27417.1 1691 1.2e-185 putative sugar transporter 4_1 [Phaedon cochleariae] 195586810 XM_002083125.1 43 1.29574e-10 Drosophila simulans GD13586 (Dsim\GD13586), mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 P20303 941 4.7e-100 Solute carrier family 2, facilitated glucose transporter member 1 OS=Sus scrofa GN=SLC2A1 PE=2 SV=2 PF07690//PF08157//PF00083 Major Facilitator Superfamily//NUC129 domain//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0569 Permease of the major facilitator superfamily Cluster-8309.35076 BP_3 7503.00 1258.60 579 264667439 ACY71305.1 721 9.4e-74 ribosomal protein S10 [Chrysomela tremula] 70909510 AM048942.1 119 1.76201e-53 Agriotes lineatus mRNA for ribosomal protein S10e (rpS10e gene) K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 Q962R9 585 2.3e-59 40S ribosomal protein S10 OS=Spodoptera frugiperda GN=RpS10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3344 40s ribosomal protein s10 Cluster-8309.35077 BP_3 100.49 0.85 5968 91077054 XP_966585.1 1457 4.4e-158 PREDICTED: probable transaldolase [Tribolium castaneum]>gi|270001740|gb|EEZ98187.1| hypothetical protein TcasGA2_TC000616 [Tribolium castaneum] 746851965 XM_011058220.1 116 8.91725e-51 PREDICTED: Acromyrmex echinatior probable transaldolase (LOC105147307), mRNA K00616 E2.2.1.2, talA, talB transaldolase http://www.genome.jp/dbget-bin/www_bget?ko:K00616 Q9EQS0 1175 9.0e-127 Transaldolase OS=Rattus norvegicus GN=Taldo1 PE=1 SV=2 PF13855//PF02428//PF00923 Leucine rich repeat//Potato type II proteinase inhibitor family//Transaldolase GO:0006098//GO:0005975 pentose-phosphate shunt//carbohydrate metabolic process GO:0004867//GO:0005515//GO:0004801 serine-type endopeptidase inhibitor activity//protein binding//sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity GO:0005737 cytoplasm KOG2772 Transaldolase Cluster-8309.35078 BP_3 523.68 10.08 2797 546676952 ERL87876.1 1563 1.0e-170 hypothetical protein D910_05264 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 803 5.8e-84 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01700//PF03015//PF08685//PF01370//PF01073 Orbivirus VP3 (T2) protein//Male sterility protein//GON domain//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0005198//GO:0016616//GO:0004222//GO:0003854//GO:0050662//GO:0003824//GO:0080019//GO:0008270 structural molecule activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//metalloendopeptidase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//fatty-acyl-CoA reductase (alcohol-forming) activity//zinc ion binding -- -- -- -- Cluster-8309.35079 BP_3 501.08 6.51 4001 332375078 AEE62680.1 1234 2.1e-132 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14457 MOGAT2, MGAT2 2-acylglycerol O-acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14457 Q70VZ7 681 1.2e-69 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.35080 BP_3 1269.00 60.97 1295 820805568 AKG92775.1 812 5.9e-84 enhancer of split mgamma protein 2 [Leptinotarsa decemlineata] 820805567 KP147938.1 220 2.91243e-109 Leptinotarsa decemlineata enhancer of split mgamma protein 2 mRNA, complete cds K09090 HESN hairy and enhancer of split, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09090 Q01069 380 3.0e-35 Enhancer of split mbeta protein OS=Drosophila melanogaster GN=HLHmbeta PE=2 SV=2 PF00010//PF07527 Helix-loop-helix DNA-binding domain//Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.35081 BP_3 92.48 1.01 4700 270011694 EFA08142.1 1444 1.1e-156 hypothetical protein TcasGA2_TC005759 [Tribolium castaneum] 170045052 XM_001850085.1 49 1.23277e-13 Culex quinquefasciatus heparan sulfate glucosamine 3-O-sulfotransferase 3B1, mRNA K07809 HS3ST3 http://www.genome.jp/dbget-bin/www_bget?ko:K07809 Q9QZS6 961 4.6e-102 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 OS=Mus musculus GN=Hs3st3b1 PE=2 SV=2 PF00685//PF00160 Sulfotransferase domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755//GO:0008146 peptidyl-prolyl cis-trans isomerase activity//sulfotransferase activity -- -- KOG3704 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase Cluster-8309.35082 BP_3 231.51 0.87 13098 642926407 XP_008191950.1 4404 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.18848e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.7e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF03699//PF03325//PF05920//PF02121//PF00046//PF10541//PF02376 Uncharacterised protein family (UPF0182)//Herpesvirus polymerase accessory protein//Homeobox KN domain//Phosphatidylinositol transfer protein//Homeobox domain//Nuclear envelope localisation domain//CUT domain GO:0006355//GO:0006260//GO:0006810//GO:0019079 regulation of transcription, DNA-templated//DNA replication//transport//viral genome replication GO:0030337//GO:0003677 DNA polymerase processivity factor activity//DNA binding GO:0005622//GO:0042575//GO:0016021 intracellular//DNA polymerase complex//integral component of membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.35084 BP_3 10.33 0.90 842 642920229 XP_008192257.1 440 5.2e-41 PREDICTED: 60S ribosomal protein L10a isoform X1 [Tribolium castaneum] 315115352 HQ424705.1 140 5.53589e-65 Euphydryas aurinia ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 403 4.2e-38 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00468 Ribosomal protein L34 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1570 60S ribosomal protein L10A Cluster-8309.35091 BP_3 14.58 0.59 1475 264667337 ACY71254.1 469 4.0e-44 ribosomal protein L11 [Chrysomela tremula] 769837621 XM_011631699.1 112 3.6234e-49 PREDICTED: Pogonomyrmex barbatus 60S ribosomal protein L11-like (LOC105422357), mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 P46222 458 3.1e-44 60S ribosomal protein L11 OS=Drosophila melanogaster GN=RpL11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-8309.35092 BP_3 314.26 3.11 5168 642924648 XP_008194379.1 4458 0.0e+00 PREDICTED: tensin isoform X5 [Tribolium castaneum] 642924647 XM_008196157.1 148 1.25492e-68 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X5, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 818 1.9e-85 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.35093 BP_3 64.43 1.00 3385 642922441 XP_008193170.1 2357 1.1e-262 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 751218000 XM_011163716.1 121 8.36489e-54 PREDICTED: Solenopsis invicta isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (LOC105197396), mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1929 1.9e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF00479//PF02781//PF00180 Glucose-6-phosphate dehydrogenase, NAD binding domain//Glucose-6-phosphate dehydrogenase, C-terminal domain//Isocitrate/isopropylmalate dehydrogenase GO:0006006//GO:0006749//GO:0006098//GO:0055114 glucose metabolic process//glutathione metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0004345//GO:0016616 NADP binding//glucose-6-phosphate dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.35094 BP_3 413.00 9.93 2296 91080035 XP_972573.1 1102 2.4e-117 PREDICTED: sprT-like domain-containing protein Spartan [Tribolium castaneum]>gi|270004629|gb|EFA01077.1| hypothetical protein TcasGA2_TC003998 [Tribolium castaneum] 194768994 XM_001966557.1 35 3.62342e-06 Drosophila ananassae GF22256 (Dana\GF22256), mRNA -- -- -- -- Q9H040 842 1.4e-88 SprT-like domain-containing protein Spartan OS=Homo sapiens GN=SPRTN PE=1 SV=2 PF15926//PF00942 E3 ubiquitin-protein ligase RNF220//Cellulose binding domain GO:0016567//GO:0005975//GO:0006281//GO:0090263 protein ubiquitination//carbohydrate metabolic process//DNA repair//positive regulation of canonical Wnt signaling pathway GO:0003677//GO:0030248 DNA binding//cellulose binding -- -- KOG3931 Uncharacterized conserved protein Cluster-8309.35095 BP_3 199.41 8.68 1399 478256793 ENN76971.1 289 2.8e-23 hypothetical protein YQE_06539, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35096 BP_3 354.65 2.52 7078 270006664 EFA03112.1 343 7.8e-29 hypothetical protein TcasGA2_TC013022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15001 AP-5 complex subunit sigma-1 GO:0000724//GO:0016197 double-strand break repair via homologous recombination//endosomal transport -- -- GO:0030119 AP-type membrane coat adaptor complex -- -- Cluster-8309.35097 BP_3 6743.96 48.54 6988 646710887 KDR16277.1 5752 0.0e+00 Myosin-XVIIIa, partial [Zootermopsis nevadensis] 817181759 XM_012425868.1 44 1.1054e-10 PREDICTED: Orussus abietinus unconventional myosin-XVIIIa (LOC105699960), transcript variant X6, mRNA K10362 MYO18 myosin XVIII http://www.genome.jp/dbget-bin/www_bget?ko:K10362 Q92614 3235 0.0e+00 Unconventional myosin-XVIIIa OS=Homo sapiens GN=MYO18A PE=1 SV=3 PF13180//PF01213//PF01418//PF00005//PF01576//PF00063//PF00612//PF00595 PDZ domain//Adenylate cyclase associated (CAP) N terminal//Helix-turn-helix domain, rpiR family//ABC transporter//Myosin tail//Myosin head (motor domain)//IQ calmodulin-binding motif//PDZ domain (Also known as DHR or GLGF) GO:0007010//GO:0006355 cytoskeleton organization//regulation of transcription, DNA-templated GO:0005515//GO:0003779//GO:0005524//GO:0003700//GO:0003774//GO:0016887 protein binding//actin binding//ATP binding//transcription factor activity, sequence-specific DNA binding//motor activity//ATPase activity GO:0005667//GO:0016459 transcription factor complex//myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.35099 BP_3 182.62 3.11 3122 189236205 XP_970721.2 1657 1.5e-181 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] 569534448 KF724681.1 71 4.80605e-26 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q91WW7 529 3.8e-52 Patatin-like phospholipase domain-containing protein 3 OS=Mus musculus GN=Pnpla3 PE=2 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.35100 BP_3 34.00 0.59 3056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35102 BP_3 166.30 3.82 2388 820805538 AKG92760.1 581 6.6e-57 extra macrochaetae [Leptinotarsa decemlineata] 195428687 XM_002062365.1 43 1.34668e-10 Drosophila willistoni GK17519 (Dwil\GK17519), mRNA K17696 EMC DNA-binding protein inhibitor ID, other http://www.genome.jp/dbget-bin/www_bget?ko:K17696 P18491 260 4.5e-21 Protein extra-macrochaetae OS=Drosophila melanogaster GN=emc PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.35103 BP_3 497.00 11.95 2296 91076862 XP_974945.1 1190 1.5e-127 PREDICTED: zinc finger protein Elbow [Tribolium castaneum]>gi|270002797|gb|EEZ99244.1| elbow B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UFS5 332 2.0e-29 Zinc finger protein 503 OS=Danio rerio GN=znf503 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.35104 BP_3 28.29 0.74 2127 642918909 XP_008191651.1 191 9.8e-12 PREDICTED: interaptin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35106 BP_3 45.48 0.56 4206 642928027 XP_008200126.1 1921 4.8e-212 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 5.02035e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 993 8.1e-106 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF05531//PF07851//PF16326//PF04111//PF13499//PF13833//PF13405//PF12763//PF10186//PF01920//PF04728//PF03836//PF00036//PF13202 Nucleopolyhedrovirus P10 protein//TMPIT-like protein//ABC transporter C-terminal domain//Autophagy protein Apg6//EF-hand domain pair//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand//Vacuolar sorting 38 and autophagy-related subunit 14//Prefoldin subunit//Lipoprotein leucine-zipper//RasGAP C-terminus//EF hand//EF hand GO:0010508//GO:0007264//GO:0006914//GO:0006457 positive regulation of autophagy//small GTPase mediated signal transduction//autophagy//protein folding GO:0005509//GO:0051082//GO:0005515//GO:0005096//GO:0003677 calcium ion binding//unfolded protein binding//protein binding//GTPase activator activity//DNA binding GO:0016272//GO:0019867//GO:0016021//GO:0019028 prefoldin complex//outer membrane//integral component of membrane//viral capsid KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.35107 BP_3 1060.16 28.70 2072 642932259 XP_008197036.1 1125 4.8e-120 PREDICTED: ancient ubiquitous protein 1-like [Tribolium castaneum]>gi|270012314|gb|EFA08762.1| hypothetical protein TcasGA2_TC006447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBN5 367 1.5e-33 Ancient ubiquitous protein 1 OS=Danio rerio GN=aup1 PE=2 SV=2 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35108 BP_3 147.68 1.32 5678 91087085 XP_974959.1 1184 1.9e-126 PREDICTED: phytepsin [Tribolium castaneum]>gi|270010541|gb|EFA06989.1| hypothetical protein TcasGA2_TC009950 [Tribolium castaneum] -- -- -- -- -- K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 593 2.6e-59 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF03145//PF01186//PF00026//PF02176 Seven in absentia protein family//Lysyl oxidase//Eukaryotic aspartyl protease//TRAF-type zinc finger GO:0006508//GO:0006511//GO:0055114//GO:0007275 proteolysis//ubiquitin-dependent protein catabolic process//oxidation-reduction process//multicellular organismal development GO:0008270//GO:0004190//GO:0005507//GO:0016641 zinc ion binding//aspartic-type endopeptidase activity//copper ion binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0005634 nucleus KOG1339 Aspartyl protease Cluster-8309.3511 BP_3 5.34 0.44 872 795066599 XP_011874447.1 156 4.6e-08 PREDICTED: acylphosphatase-1-like isoform X3 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35111 BP_3 66.92 0.35 9639 815914229 XP_012242394.1 2221 1.8e-246 PREDICTED: uncharacterized protein LOC100740589 isoform X1 [Bombus impatiens] 642918459 XM_008193262.1 304 4.47333e-155 PREDICTED: Tribolium castaneum FH1/FH2 domain-containing protein 3 (LOC659452), transcript variant X5, mRNA -- -- -- -- Q76LL6 1232 3.6e-133 FH1/FH2 domain-containing protein 3 OS=Mus musculus GN=Fhod3 PE=1 SV=1 PF00895//PF01059 ATP synthase protein 8//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006120//GO:0015986//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled proton transport//proton transport//oxidation-reduction process GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG1925 Rac1 GTPase effector FHOS Cluster-8309.35112 BP_3 165.15 1.61 5223 91094043 XP_968570.1 2945 0.0e+00 PREDICTED: peroxidasin [Tribolium castaneum]>gi|270004795|gb|EFA01243.1| peroxidasin [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q9VZZ4 2310 1.9e-258 Peroxidasin OS=Drosophila melanogaster GN=Pxn PE=1 SV=1 PF13855//PF02480//PF07354//PF13895//PF02918//PF09728 Leucine rich repeat//Alphaherpesvirus glycoprotein E//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Pertussis toxin, subunit 2 and 3, C-terminal domain//Myosin-like coiled-coil protein GO:0006804//GO:0007339//GO:0006979//GO:0009405//GO:0055114 obsolete peroxidase reaction//binding of sperm to zona pellucida//response to oxidative stress//pathogenesis//oxidation-reduction process GO:0019905//GO:0005515//GO:0020037//GO:0004601 syntaxin binding//protein binding//heme binding//peroxidase activity GO:0005576//GO:0016020 extracellular region//membrane KOG2408 Peroxidase/oxygenase Cluster-8309.35114 BP_3 134.11 0.81 8228 91088689 XP_974981.1 866 2.0e-89 PREDICTED: protein phosphatase 1 regulatory subunit 7 [Tribolium castaneum] 665810299 XM_008555343.1 133 4.36498e-60 PREDICTED: Microplitis demolitor eukaryotic translation initiation factor 5A (LOC103575518), transcript variant X2, mRNA K17550 PPP1R7, SDS22 protein phosphatase 1 regulatory subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17550 Q5HZV9 606 1.2e-60 Protein phosphatase 1 regulatory subunit 7 OS=Rattus norvegicus GN=Ppp1r7 PE=1 SV=1 PF01287//PF13912//PF00560//PF00651//PF00096//PF13855 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//C2H2-type zinc finger//Leucine Rich Repeat//BTB/POZ domain//Zinc finger, C2H2 type//Leucine rich repeat GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0005515//GO:0043022//GO:0003723//GO:0046872//GO:0003746 protein binding//ribosome binding//RNA binding//metal ion binding//translation elongation factor activity GO:0005840 ribosome KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.35115 BP_3 139.61 3.64 2142 270012283 EFA08731.1 783 2.2e-80 hypothetical protein TcasGA2_TC006406 [Tribolium castaneum] 665810299 XM_008555343.1 133 1.12353e-60 PREDICTED: Microplitis demolitor eukaryotic translation initiation factor 5A (LOC103575518), transcript variant X2, mRNA K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 P62924 727 2.9e-75 Eukaryotic translation initiation factor 5A OS=Spodoptera exigua GN=eIF-5A PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0003723//GO:0043022//GO:0003746 RNA binding//ribosome binding//translation elongation factor activity GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-8309.35116 BP_3 149.26 1.81 4267 478263754 ENN82050.1 1654 4.5e-181 hypothetical protein YQE_01563, partial [Dendroctonus ponderosae] -- -- -- -- -- K17083 FERMT2, KIND2 kindlin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17083 Q9VZI3 1152 3.0e-124 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.35119 BP_3 760.80 4.81 7911 642911937 XP_008199029.1 3528 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 585 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1858 7.6e-206 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF07043//PF08397//PF00885//PF03114//PF00018//PF14604//PF00023//PF00465//PF01412//PF13606 Protein of unknown function (DUF1328)//IRSp53/MIM homology domain//6,7-dimethyl-8-ribityllumazine synthase//BAR domain//SH3 domain//Variant SH3 domain//Ankyrin repeat//Iron-containing alcohol dehydrogenase//Putative GTPase activating protein for Arf//Ankyrin repeat GO:0009231//GO:0007009//GO:0055114 riboflavin biosynthetic process//plasma membrane organization//oxidation-reduction process GO:0005096//GO:0005515//GO:0016491//GO:0046872 GTPase activator activity//protein binding//oxidoreductase activity//metal ion binding GO:0005886//GO:0009349//GO:0005737 plasma membrane//riboflavin synthase complex//cytoplasm KOG3857 Alcohol dehydrogenase, class IV Cluster-8309.3512 BP_3 5.00 2.77 376 642922420 XP_008193148.1 246 7.3e-19 PREDICTED: protein lifeguard 3-like [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q8BJZ3 169 2.5e-11 Protein lifeguard 3 OS=Mus musculus GN=Tmbim1 PE=1 SV=1 PF05313 Poxvirus P21 membrane protein -- -- -- -- GO:0016021 integral component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.35120 BP_3 668.33 6.36 5356 91094499 XP_971436.1 1375 1.3e-148 PREDICTED: phosphopantothenate--cysteine ligase [Tribolium castaneum]>gi|270000749|gb|EEZ97196.1| hypothetical protein TcasGA2_TC004384 [Tribolium castaneum] -- -- -- -- -- K01922 PPCS, coaB phosphopantothenate-cysteine ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01922 Q9HAB8 616 5.3e-62 Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2728 Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase Cluster-8309.35122 BP_3 139.60 1.00 7047 91086487 XP_970606.1 1037 2.6e-109 PREDICTED: putative Rab-43-like protein ENSP00000330714 [Tribolium castaneum]>gi|270009806|gb|EFA06254.1| hypothetical protein TcasGA2_TC009113 [Tribolium castaneum] -- -- -- -- -- K07930 RAB43 Ras-related protein Rab-43 http://www.genome.jp/dbget-bin/www_bget?ko:K07930 Q86YS6 619 3.1e-62 Ras-related protein Rab-43 OS=Homo sapiens GN=RAB43 PE=1 SV=1 PF00096//PF00025//PF08513//PF01926//PF08710//PF08477//PF00071//PF10662//PF04670//PF02367 Zinc finger, C2H2 type//ADP-ribosylation factor family//LisH//50S ribosome-binding GTPase//nsp9 replicase//Ras of Complex, Roc, domain of DAPkinase//Ras family//Ethanolamine utilisation - propanediol utilisation//Gtr1/RagA G protein conserved region//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0007264//GO:0015031//GO:0002949//GO:0006576//GO:0019079 small GTPase mediated signal transduction//protein transport//tRNA threonylcarbamoyladenosine modification//cellular biogenic amine metabolic process//viral genome replication GO:0046872//GO:0005525//GO:0005515//GO:0005524//GO:0003723 metal ion binding//GTP binding//protein binding//ATP binding//RNA binding -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.35123 BP_3 65.05 6.39 782 642922066 XP_966808.3 208 3.9e-14 PREDICTED: putative thiosulfate sulfurtransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q10215 162 3.4e-10 Putative thiosulfate sulfurtransferase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4H3.07c PE=3 SV=2 PF09030 Creb binding GO:0006355//GO:0016573//GO:0042967 regulation of transcription, DNA-templated//histone acetylation//acyl-carrier-protein biosynthetic process GO:0004402//GO:0003713 histone acetyltransferase activity//transcription coactivator activity GO:0000123//GO:0005634//GO:0005667 histone acetyltransferase complex//nucleus//transcription factor complex -- -- Cluster-8309.35124 BP_3 1629.00 245.89 611 91094797 XP_966355.1 389 3.1e-35 PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|642922944|ref|XP_008200463.1| PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|642922946|ref|XP_008200464.1| PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|270006580|gb|EFA03028.1| hypothetical protein TcasGA2_TC010452 [Tribolium castaneum] 759061379 XM_011341716.1 114 1.12272e-50 PREDICTED: Cerapachys biroi elongation factor 1-alpha (LOC105280864), transcript variant X2, mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P19039 371 1.6e-34 Elongation factor 1-alpha OS=Apis mellifera PE=3 SV=1 PF02615 Malate/L-lactate dehydrogenase GO:0055114//GO:0006184//GO:0006448//GO:0008152//GO:0006414 oxidation-reduction process//obsolete GTP catabolic process//regulation of translational elongation//metabolic process//translational elongation GO:0003746//GO:0005525//GO:0003924//GO:0016491 translation elongation factor activity//GTP binding//GTPase activity//oxidoreductase activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.35126 BP_3 424.00 35.28 871 -- -- -- -- -- 403311088 JX457150.1 811 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35127 BP_3 216.80 3.39 3377 546674506 ERL85871.1 220 6.8e-15 hypothetical protein D910_03286 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35128 BP_3 11197.52 44.05 12544 270007509 EFA03957.1 1887 1.3e-207 hypothetical protein TcasGA2_TC014101 [Tribolium castaneum] 332374221 BT127290.1 481 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA -- -- -- -- O16011 771 1.3e-79 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF01522//PF02198//PF00642//PF01607 MMPL family//Polysaccharide deacetylase//Sterile alpha motif (SAM)/Pointed domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Chitin binding Peritrophin-A domain GO:0006030//GO:0006807//GO:0005975 chitin metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process GO:0016810//GO:0008061//GO:0046872//GO:0043565 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding//metal ion binding//sequence-specific DNA binding GO:0005634//GO:0005576//GO:0016020 nucleus//extracellular region//membrane KOG2494 C3H1-type Zn-finger protein Cluster-8309.35129 BP_3 981.00 19.93 2664 642923423 XP_008193738.1 589 8.7e-58 PREDICTED: transmembrane protein 18 [Tribolium castaneum]>gi|270007022|gb|EFA03470.1| hypothetical protein TcasGA2_TC013466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641M3 284 8.3e-24 Transmembrane protein 18 OS=Danio rerio GN=tmem18 PE=2 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.35130 BP_3 52.32 2.92 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35131 BP_3 1305.40 29.44 2429 642938996 XP_008200109.1 1048 4.7e-111 PREDICTED: serine protease inhibitor 3/4-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 579 4.7e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35132 BP_3 209.21 3.89 2884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115 SFI toxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.35133 BP_3 496.19 3.12 7949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03611//PF08115 PTS system sugar-specific permease component//SFI toxin family GO:0009405//GO:0009401 pathogenesis//phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.35135 BP_3 16.24 0.45 2014 642922332 XP_008193116.1 630 1.2e-62 PREDICTED: prickle-like protein 3 isoform X1 [Tribolium castaneum] 642922338 XM_970895.3 209 5.95932e-103 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X5, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 O35115 451 2.7e-43 Four and a half LIM domains protein 2 OS=Rattus norvegicus GN=Fhl2 PE=1 SV=1 PF14634//PF02502//PF00412 zinc-RING finger domain//Ribose/Galactose Isomerase//LIM domain GO:0005975 carbohydrate metabolic process GO:0008270//GO:0005515//GO:0016853 zinc ion binding//protein binding//isomerase activity -- -- KOG1704 FOG: LIM domain Cluster-8309.35136 BP_3 1024.93 186.17 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35137 BP_3 461.74 28.16 1082 642922334 XP_008193117.1 1034 8.9e-110 PREDICTED: four and a half LIM domains protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43900 436 8.0e-42 Prickle-like protein 3 OS=Homo sapiens GN=PRICKLE3 PE=1 SV=2 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.35139 BP_3 1396.02 32.55 2359 642922332 XP_008193116.1 1680 2.4e-184 PREDICTED: prickle-like protein 3 isoform X1 [Tribolium castaneum] 642922336 XM_008194896.1 488 0 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X4, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 1001 5.3e-107 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF07562//PF00412 Nine Cysteines Domain of family 3 GPCR//LIM domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0008270 G-protein coupled receptor activity//zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.35142 BP_3 3213.24 8.02 19592 646716100 KDR19487.1 3053 0.0e+00 E3 ubiquitin-protein ligase MARCH6 [Zootermopsis nevadensis] 847042359 XM_012951711.1 93 1.79317e-37 PREDICTED: Jaculus jaculus membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (March6), mRNA K10661 MARCH6, DOA10 E3 ubiquitin-protein ligase MARCH6 http://www.genome.jp/dbget-bin/www_bget?ko:K10661 O60337 1868 1.3e-206 E3 ubiquitin-protein ligase MARCH6 OS=Homo sapiens GN=MARCH6 PE=1 SV=2 PF12906//PF03165//PF00400//PF00004//PF13639 RING-variant domain//MH1 domain//WD domain, G-beta repeat//ATPase family associated with various cellular activities (AAA)//Ring finger domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0008270//GO:0005515 ATP binding//zinc ion binding//protein binding GO:0005622 intracellular KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.35145 BP_3 42.20 0.67 3348 91077070 XP_969313.1 2463 5.5e-275 PREDICTED: metal transporter CNNM4 [Tribolium castaneum]>gi|270002030|gb|EEZ98477.1| hypothetical protein TcasGA2_TC000970 [Tribolium castaneum] 642913385 XM_964220.3 350 0 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q9H8M5 1341 2.8e-146 Metal transporter CNNM2 OS=Homo sapiens GN=CNNM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.35146 BP_3 9.61 0.92 796 642915229 XP_008190531.1 386 9.0e-35 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 233 2.0e-18 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35150 BP_3 13.00 1.78 643 189240245 XP_001810808.1 198 4.6e-13 PREDICTED: uncharacterized protein LOC100141766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35151 BP_3 77.63 3.06 1516 642939160 XP_969591.2 880 8.9e-92 PREDICTED: protein D3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 625 1.4e-63 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.35152 BP_3 87.37 2.29 2132 91089929 XP_973045.1 495 5.5e-47 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04309//PF00436 Glycerol-3-phosphate responsive antiterminator//Single-strand binding protein family GO:0009607//GO:0006355 response to biotic stimulus//regulation of transcription, DNA-templated GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.35153 BP_3 1037.72 3.94 12998 642931031 XP_008196185.1 5935 0.0e+00 PREDICTED: Ig-like and fibronectin type-III domain-containing protein T04A11.3 [Tribolium castaneum] -- -- -- -- -- K00109 E1.1.99.2 2-hydroxyglutarate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00109 Q964T2 917 1.6e-96 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF13895//PF00041//PF04893//PF16656//PF01313//PF01108//PF04142//PF00892//PF01266//PF00067 Immunoglobulin domain//Fibronectin type III domain//Yip1 domain//Purple acid Phosphatase, N-terminal domain//Bacterial export proteins, family 3//Tissue factor//Nucleotide-sugar transporter//EamA-like transporter family//FAD dependent oxidoreductase//Cytochrome P450 GO:0019497//GO:0009306//GO:0055114//GO:0008643//GO:0006771 hexachlorocyclohexane metabolic process//protein secretion//oxidation-reduction process//carbohydrate transport//riboflavin metabolic process GO:0005351//GO:0005506//GO:0003993//GO:0016491//GO:0005515//GO:0016705//GO:0046872//GO:0020037 sugar:proton symporter activity//iron ion binding//acid phosphatase activity//oxidoreductase activity//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//metal ion binding//heme binding GO:0016021//GO:0016020//GO:0000139 integral component of membrane//membrane//Golgi membrane -- -- Cluster-8309.35160 BP_3 1676.69 16.45 5204 642911559 XP_970343.3 5016 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4083 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF01080//PF06333//PF08074//PF02535//PF00176//PF01874//PF04851//PF02724 Presenilin//Mediator complex subunit 13 C-terminal//CHDCT2 (NUC038) domain//ZIP Zinc transporter//SNF2 family N-terminal domain//ATP:dephospho-CoA triphosphoribosyl transferase//Type III restriction enzyme, res subunit//CDC45-like protein GO:0006270//GO:0055085//GO:0006357//GO:0006355//GO:0016310//GO:0030001 DNA replication initiation//transmembrane transport//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//phosphorylation//metal ion transport GO:0016787//GO:0005524//GO:0016818//GO:0008270//GO:0046917//GO:0004190//GO:0001104//GO:0003677//GO:0046873 hydrolase activity//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//triphosphoribosyl-dephospho-CoA synthase activity//aspartic-type endopeptidase activity//RNA polymerase II transcription cofactor activity//DNA binding//metal ion transmembrane transporter activity GO:0016021//GO:0016592//GO:0005634//GO:0016020 integral component of membrane//mediator complex//nucleus//membrane KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.35164 BP_3 699.10 32.61 1325 642936067 XP_008198289.1 667 3.9e-67 PREDICTED: 60S ribosomal protein L23a-like [Tribolium castaneum]>gi|270014014|gb|EFA10462.1| hypothetical protein TcasGA2_TC012708 [Tribolium castaneum] 807017617 XM_004518966.2 104 9.08907e-45 PREDICTED: Ceratitis capitata 60S ribosomal protein L23a (LOC101463395), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 486 1.6e-47 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0000166 structural constituent of ribosome//nucleotide binding GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.35165 BP_3 633.09 15.11 2311 646707196 KDR14057.1 746 4.7e-76 Ras-related protein Rab-18-B [Zootermopsis nevadensis] -- -- -- -- -- K07910 RAB18 Ras-related protein Rab-18 http://www.genome.jp/dbget-bin/www_bget?ko:K07910 Q6DHC1 723 9.0e-75 Ras-related protein Rab-18-B OS=Danio rerio GN=rab18b PE=2 SV=1 PF00025//PF07475//PF01926//PF08477//PF00735//PF04670//PF00071//PF10662//PF00493//PF00076//PF00005//PF03193 ADP-ribosylation factor family//HPr Serine kinase C-terminal domain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//MCM2/3/5 family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//ABC transporter//Protein of unknown function, DUF258 GO:0006260//GO:0007264//GO:0006576//GO:0000160//GO:0016310//GO:0006109 DNA replication//small GTPase mediated signal transduction//cellular biogenic amine metabolic process//phosphorelay signal transduction system//phosphorylation//regulation of carbohydrate metabolic process GO:0005525//GO:0003676//GO:0016887//GO:0004672//GO:0005524//GO:0000155//GO:0003677//GO:0003924 GTP binding//nucleic acid binding//ATPase activity//protein kinase activity//ATP binding//phosphorelay sensor kinase activity//DNA binding//GTPase activity GO:0009365 protein histidine kinase complex KOG0080 GTPase Rab18, small G protein superfamily Cluster-8309.35166 BP_3 550.95 7.51 3830 642917906 XP_970904.3 3304 0.0e+00 PREDICTED: probable 3',5'-cyclic phosphodiesterase pde-5 isoform X1 [Tribolium castaneum]>gi|270003323|gb|EEZ99770.1| hypothetical protein TcasGA2_TC002545 [Tribolium castaneum] -- -- -- -- -- K18438 PDE10 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18438 P91119 1631 7.7e-180 Probable 3',5'-cyclic phosphodiesterase pde-5 OS=Caenorhabditis elegans GN=pde-5 PE=3 SV=3 PF13185//PF13492//PF00233//PF01590 GAF domain//GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain GO:0007165//GO:0008152//GO:0006144 signal transduction//metabolic process//purine nucleobase metabolic process GO:0004114//GO:0046872//GO:0005515 3',5'-cyclic-nucleotide phosphodiesterase activity//metal ion binding//protein binding -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.35167 BP_3 7.83 0.47 1091 642913579 XP_008201071.1 283 1.1e-22 PREDICTED: succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K00236 SDHC, SDH3 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00236 Q99643 190 2.7e-13 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial OS=Homo sapiens GN=SDHC PE=1 SV=1 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0449 Succinate dehydrogenase, cytochrome b subunit Cluster-8309.35168 BP_3 1707.00 64.37 1570 546677591 ERL88396.1 886 1.9e-92 hypothetical protein D910_05782 [Dendroctonus ponderosae] -- -- -- -- -- K17292 TBCA tubulin-specific chaperone A http://www.genome.jp/dbget-bin/www_bget?ko:K17292 Q6PEC1 277 3.2e-23 Tubulin-specific chaperone A OS=Rattus norvegicus GN=Tbca PE=1 SV=1 PF02970 Tubulin binding cofactor A GO:0007021 tubulin complex assembly GO:0015631//GO:0051082 tubulin binding//unfolded protein binding GO:0045298 tubulin complex KOG3470 Beta-tubulin folding cofactor A Cluster-8309.35169 BP_3 209.52 5.04 2295 270006792 EFA03240.1 481 2.5e-45 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZA47 308 1.2e-26 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF07994 Myo-inositol-1-phosphate synthase GO:0008654//GO:0006021//GO:0019872 phospholipid biosynthetic process//inositol biosynthetic process//streptomycin biosynthetic process GO:0004512 inositol-3-phosphate synthase activity -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35171 BP_3 773.97 33.06 1420 478257902 ENN78042.1 440 8.8e-41 hypothetical protein YQE_05479, partial [Dendroctonus ponderosae] -- -- -- -- -- K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 -- -- -- -- PF10408 Ubiquitin elongating factor core GO:0016567//GO:0006511 protein ubiquitination//ubiquitin-dependent protein catabolic process GO:0034450 ubiquitin-ubiquitin ligase activity GO:0000151 ubiquitin ligase complex -- -- Cluster-8309.35172 BP_3 1392.47 128.76 813 642937735 XP_008198925.1 703 1.6e-71 PREDICTED: tropomyosin-1, isoforms 9A/A/B isoform X18 [Tribolium castaneum] 780660607 XM_011694427.1 174 6.71147e-84 PREDICTED: Wasmannia auropunctata tropomyosin (LOC105452880), transcript variant X17, mRNA K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 P06754 574 6.0e-58 Tropomyosin-1, isoforms 9A/A/B OS=Drosophila melanogaster GN=Tm1 PE=2 SV=2 PF10186//PF00769//PF16716//PF07926//PF02185//PF06009 Vacuolar sorting 38 and autophagy-related subunit 14//Ezrin/radixin/moesin family//Bone marrow stromal antigen 2//TPR/MLP1/MLP2-like protein//Hr1 repeat//Laminin Domain II GO:0051607//GO:0007165//GO:0010508//GO:0006606//GO:0007155 defense response to virus//signal transduction//positive regulation of autophagy//protein import into nucleus//cell adhesion GO:0008092 cytoskeletal protein binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.35175 BP_3 52.72 3.96 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35176 BP_3 669.50 4.87 6918 642918310 XP_008191453.1 3659 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] -- -- -- -- -- K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 Q96PE3 739 3.8e-76 Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 PF00168//PF01530//PF01017 C2 domain//Zinc finger, C2HC type//STAT protein, all-alpha domain GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0008270//GO:0004871 protein binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//signal transducer activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.35177 BP_3 627.67 2.43 12719 817208819 XP_012280436.1 6915 0.0e+00 PREDICTED: uncharacterized protein LOC105699757 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q9U943 866 1.3e-90 Apolipophorins OS=Locusta migratoria PE=1 SV=2 PF06448//PF01347//PF09172 Domain of Unknown Function (DUF1081)//Lipoprotein amino terminal region//Domain of unknown function (DUF1943) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- KOG4338 Predicted lipoprotein Cluster-8309.35178 BP_3 94.17 3.36 1644 642912151 XP_008200828.1 1158 5.6e-124 PREDICTED: uridine phosphorylase 1-like isoform X1 [Tribolium castaneum]>gi|270002489|gb|EEZ98936.1| hypothetical protein TcasGA2_TC004559 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 P52624 626 1.1e-63 Uridine phosphorylase 1 OS=Mus musculus GN=Upp1 PE=1 SV=2 PF01048 Phosphorylase superfamily GO:0006206//GO:0009116//GO:0009166 pyrimidine nucleobase metabolic process//nucleoside metabolic process//nucleotide catabolic process GO:0004850//GO:0003824 uridine phosphorylase activity//catalytic activity GO:0005737 cytoplasm KOG3728 Uridine phosphorylase Cluster-8309.35179 BP_3 605.07 4.40 6917 642930669 XP_008199217.1 1785 4.7e-196 PREDICTED: uncharacterized protein LOC657834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12036 282 3.7e-23 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF03007 Wax ester synthase-like Acyl-CoA acyltransferase domain GO:0045017//GO:0046486//GO:0042967 glycerolipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.35180 BP_3 14.72 0.64 1397 264667427 ACY71299.1 985 5.5e-104 ribosomal protein L7A [Chrysomela tremula] 161015754 EU259814.1 143 2.00505e-66 Spodoptera exigua ribosomal protein L7A (RpL7A) mRNA, complete cds K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P46223 854 3.5e-90 60S ribosomal protein L7a OS=Drosophila melanogaster GN=RpL7A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8309.35181 BP_3 123.15 7.46 1087 332374344 AEE62313.1 1081 3.2e-115 unknown [Dendroctonus ponderosae]>gi|478253634|gb|ENN73938.1| hypothetical protein YQE_09440, partial [Dendroctonus ponderosae]>gi|546684541|gb|ERL94169.1| hypothetical protein D910_11451 [Dendroctonus ponderosae] -- -- -- -- -- K01069 E3.1.2.6, gloB hydroxyacylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01069 Q3B7M2 858 9.4e-91 Hydroxyacylglutathione hydrolase, mitochondrial OS=Bos taurus GN=HAGH PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0813 Glyoxylase Cluster-8309.35183 BP_3 7407.96 106.16 3655 91088385 XP_972387.1 1045 1.6e-110 PREDICTED: cytosolic Fe-S cluster assembly factor NUBP2 homolog [Tribolium castaneum]>gi|270011770|gb|EFA08218.1| hypothetical protein TcasGA2_TC005845 [Tribolium castaneum] 53830697 AY725779.1 166 8.72513e-79 Oncometopia nigricans putative cytoplasmic actin A3a1 mRNA, complete cds -- -- -- -- Q16H50 904 1.5e-95 Cytosolic Fe-S cluster assembly factor NUBP2 homolog OS=Aedes aegypti GN=AAEL008143 PE=3 SV=1 PF13181//PF01583//PF00448//PF13174//PF03205//PF00515//PF06414//PF13371//PF03266//PF03193//PF00931//PF13176//PF13414 Tetratricopeptide repeat//Adenylylsulphate kinase//SRP54-type protein, GTPase domain//Tetratricopeptide repeat//Molybdopterin guanine dinucleotide synthesis protein B//Tetratricopeptide repeat//Zeta toxin//Tetratricopeptide repeat//NTPase//Protein of unknown function, DUF258//NB-ARC domain//Tetratricopeptide repeat//TPR repeat GO:0000103//GO:0006144//GO:0006614//GO:0006777 sulfate assimilation//purine nucleobase metabolic process//SRP-dependent cotranslational protein targeting to membrane//Mo-molybdopterin cofactor biosynthetic process GO:0003924//GO:0004020//GO:0005515//GO:0043531//GO:0098519//GO:0005524//GO:0016301//GO:0005525 GTPase activity//adenylylsulfate kinase activity//protein binding//ADP binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//kinase activity//GTP binding -- -- KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.35184 BP_3 1993.57 18.90 5375 642924658 XP_008194384.1 4650 0.0e+00 PREDICTED: tensin isoform X10 [Tribolium castaneum] 642924663 XM_008196165.1 42 1.09866e-09 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X13, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q04205 811 1.3e-84 Tensin OS=Gallus gallus GN=TNS PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.35185 BP_3 241.66 3.48 3641 91083607 XP_969406.1 1301 3.3e-140 PREDICTED: solute carrier family 25 member 44 [Tribolium castaneum]>gi|270007841|gb|EFA04289.1| hypothetical protein TcasGA2_TC014580 [Tribolium castaneum] -- -- -- -- -- K15121 SLC25A44 solute carrier family 25, member 44 http://www.genome.jp/dbget-bin/www_bget?ko:K15121 Q5RD67 658 4.9e-67 Solute carrier family 25 member 44 OS=Pongo abelii GN=SLC25A44 PE=2 SV=2 PF03689//PF00096 Nepovirus coat protein, N-terminal domain//Zinc finger, C2H2 type GO:0055085 transmembrane transport GO:0046872 metal ion binding GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG0765 Predicted mitochondrial carrier protein Cluster-8309.35187 BP_3 18.72 0.46 2266 642922975 XP_008200476.1 1247 3.7e-134 PREDICTED: growth hormone-regulated TBC protein 1 [Tribolium castaneum]>gi|270006542|gb|EFA02990.1| hypothetical protein TcasGA2_TC010409 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TC63 719 2.6e-74 Growth hormone-regulated TBC protein 1 OS=Homo sapiens GN=GRTP1 PE=1 SV=4 PF00947 Picornavirus core protein 2A GO:0006508//GO:0016032 proteolysis//viral process GO:0008233 peptidase activity GO:0005622 intracellular KOG2058 Ypt/Rab GTPase activating protein Cluster-8309.35188 BP_3 43.18 0.89 2624 255522799 NP_001157312.1 288 6.9e-23 longitudinals lacking isoform 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 263 2.2e-21 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01155//PF02176//PF13465//PF00096//PF05191 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TRAF-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Adenylate kinase, active site lid GO:0006464//GO:0046034//GO:0006144 cellular protein modification process//ATP metabolic process//purine nucleobase metabolic process GO:0008270//GO:0016151//GO:0004017//GO:0046872 zinc ion binding//nickel cation binding//adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.35189 BP_3 102.70 2.60 2196 761896177 AJP75146.1 1663 2.1e-182 alanine aminotransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 Q6GM82 1162 1.1e-125 Alanine aminotransferase 2 OS=Xenopus laevis GN=gpt2 PE=2 SV=1 PF01212//PF00155 Beta-eliminating lyase//Aminotransferase class I and II GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG0258 Alanine aminotransferase Cluster-8309.3519 BP_3 12.63 0.40 1828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35190 BP_3 283.00 3.53 4153 642919333 XP_008191829.1 1602 4.7e-175 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AVA0 285 9.9e-24 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus GN=Svep1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35191 BP_3 5159.00 362.34 978 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35192 BP_3 322.92 12.78 1510 270006122 EFA02570.1 416 5.7e-38 hypothetical protein TcasGA2_TC008280 [Tribolium castaneum] -- -- -- -- -- K06850 SLIT3 slit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06850 O75094 173 3.5e-11 Slit homolog 3 protein OS=Homo sapiens GN=SLIT3 PE=2 SV=3 PF13413//PF00560//PF13516//PF13855 Helix-turn-helix domain//Leucine Rich Repeat//Leucine Rich repeat//Leucine rich repeat -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.35193 BP_3 31.00 2.70 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35195 BP_3 1714.20 35.50 2619 546670831 ERL83427.1 3655 0.0e+00 hypothetical protein D910_00401 [Dendroctonus ponderosae] 242021484 XM_002431130.1 400 0 Pediculus humanus corporis protein transport protein Sec23A, putative, mRNA K14006 SEC23 protein transport protein SEC23 http://www.genome.jp/dbget-bin/www_bget?ko:K14006 Q01405 3143 0.0e+00 Protein transport protein Sec23A OS=Mus musculus GN=Sec23a PE=1 SV=2 PF04810//PF04811//PF04815 Sec23/Sec24 zinc finger//Sec23/Sec24 trunk domain//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1986 Vesicle coat complex COPII, subunit SEC23 Cluster-8309.35196 BP_3 1112.77 23.29 2595 478257623 ENN77775.1 3674 0.0e+00 hypothetical protein YQE_05747, partial [Dendroctonus ponderosae] 242021484 XM_002431130.1 426 0 Pediculus humanus corporis protein transport protein Sec23A, putative, mRNA K14006 SEC23 protein transport protein SEC23 http://www.genome.jp/dbget-bin/www_bget?ko:K14006 Q01405 3162 0.0e+00 Protein transport protein Sec23A OS=Mus musculus GN=Sec23a PE=1 SV=2 PF04810//PF04811//PF04815 Sec23/Sec24 zinc finger//Sec23/Sec24 trunk domain//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1986 Vesicle coat complex COPII, subunit SEC23 Cluster-8309.35198 BP_3 2288.26 160.95 977 156523066 NP_001095946.1 269 4.1e-21 chitin deacetylase 1 precursor [Tribolium castaneum]>gi|155675830|gb|ABU25223.1| chitin deacetylase 1 [Tribolium castaneum]>gi|270007508|gb|EFA03956.1| hypothetical protein TcasGA2_TC014100 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005975//GO:0006040//GO:0006030 carbohydrate metabolic process//amino sugar metabolic process//chitin metabolic process GO:0008061//GO:0004099 chitin binding//chitin deacetylase activity GO:0005576 extracellular region -- -- Cluster-8309.35199 BP_3 45.52 1.14 2213 91081961 XP_966594.1 184 6.6e-11 PREDICTED: Y-box factor homolog isoform X1 [Tribolium castaneum]>gi|270007364|gb|EFA03812.1| hypothetical protein TcasGA2_TC013925 [Tribolium castaneum] 462328436 APGK01040697.1 43 1.24652e-10 Dendroctonus ponderosae Seq01040707, whole genome shotgun sequence K09276 YBX1, NSEP1 Y-box-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09276 P41824 173 5.1e-11 Y-box factor homolog OS=Aplysia californica PE=2 SV=1 PF00313 'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.352 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3520 BP_3 14.94 0.53 1656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35200 BP_3 552.73 4.91 5723 546675647 ERL86797.1 3344 0.0e+00 hypothetical protein D910_04202 [Dendroctonus ponderosae] 170039960 XM_001847732.1 106 3.09658e-45 Culex quinquefasciatus phosphatidylinositol 3-kinase 1, mRNA K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 O35904 2100 4.7e-234 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus GN=Pik3cd PE=1 SV=2 PF02888//PF00454 Calmodulin binding domain//Phosphatidylinositol 3- and 4-kinase GO:0006813 potassium ion transport GO:0015269//GO:0016773//GO:0005516 calcium-activated potassium channel activity//phosphotransferase activity, alcohol group as acceptor//calmodulin binding GO:0016021 integral component of membrane KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110) Cluster-8309.35203 BP_3 819.00 11.87 3616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35204 BP_3 19.28 0.59 1870 270013707 EFA10155.1 376 3.1e-33 hypothetical protein TcasGA2_TC012343 [Tribolium castaneum] 642934429 XM_008199437.1 54 8.06144e-17 PREDICTED: Tribolium castaneum mitochondrial Rho GTPase (LOC657284), transcript variant X1, mRNA K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 270 2.5e-22 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.35205 BP_3 30.39 0.92 1888 91094775 XP_968026.1 520 6.2e-50 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9I1 145 7.7e-08 Cyclin-G1 OS=Bos taurus GN=CCNG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35207 BP_3 27.45 0.54 2747 642933037 XP_008197238.1 625 6.0e-62 PREDICTED: troponin C-like [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P15159 412 1.2e-38 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF12763//PF13202//PF13499//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35209 BP_3 22.52 0.32 3707 642926858 XP_008195042.1 912 4.3e-95 PREDICTED: RIMS-binding protein 2 [Tribolium castaneum] 642916156 XM_008192687.1 95 2.60405e-39 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X5, mRNA K17591 RIMBP2 RIMS-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17591 O15034 456 1.3e-43 RIMS-binding protein 2 OS=Homo sapiens GN=RIMBP2 PE=1 SV=3 PF06236//PF14604//PF00018//PF03153 Tyrosinase co-factor MelC1//Variant SH3 domain//SH3 domain//Transcription factor IIA, alpha/beta subunit GO:0042438//GO:0006367 melanin biosynthetic process//transcription initiation from RNA polymerase II promoter GO:0005507//GO:0005515 copper ion binding//protein binding GO:0005672 transcription factor TFIIA complex KOG3632 Peripheral benzodiazepine receptor PRAX-1 Cluster-8309.35210 BP_3 988.96 9.94 5086 189235271 XP_973061.2 1267 4.0e-136 PREDICTED: MKL/myocardin-like protein 2 isoform X1 [Tribolium castaneum] 642916156 XM_008192687.1 95 3.58226e-39 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X5, mRNA -- -- -- -- Q8K4J6 314 5.3e-27 MKL/myocardin-like protein 1 OS=Mus musculus GN=Mkl1 PE=1 SV=2 PF11744 Aluminium activated malate transporter GO:0015743 malate transport -- -- -- -- -- -- Cluster-8309.35212 BP_3 152.00 4.94 1775 2654204 AAC63079.1 999 1.7e-105 putative juvenile hormone esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35213 BP_3 20.59 0.43 2576 91077058 XP_968505.1 2308 3.9e-257 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] 665802087 XM_008550863.1 127 2.93295e-57 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 Q0V7M0 1916 4.6e-213 Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1 PF00514//PF11698//PF01602//PF02985//PF10508//PF16006//PF01749 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region//HEAT repeat//Proteasome non-ATPase 26S subunit//Nucleolar and spindle-associated protein//Importin beta binding domain GO:0006606//GO:0043248//GO:0015031//GO:0006886//GO:0016192//GO:0000281//GO:0000226//GO:0015991//GO:0040001 protein import into nucleus//proteasome assembly//protein transport//intracellular protein transport//vesicle-mediated transport//mitotic cytokinesis//microtubule cytoskeleton organization//ATP hydrolysis coupled proton transport//establishment of mitotic spindle localization GO:0008565//GO:0016820//GO:0005515 protein transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0005737//GO:0030117//GO:0005819//GO:0005634//GO:0000221//GO:0005874 cytoplasm//membrane coat//spindle//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain//microtubule KOG0166 Karyopherin (importin) alpha Cluster-8309.35214 BP_3 3493.98 81.66 2354 332374512 AEE62397.1 1661 3.8e-182 unknown [Dendroctonus ponderosae]>gi|478256842|gb|ENN77017.1| hypothetical protein YQE_06511, partial [Dendroctonus ponderosae]>gi|546673798|gb|ERL85342.1| hypothetical protein D910_02762 [Dendroctonus ponderosae] 557020770 XM_006010638.1 35 3.71637e-06 PREDICTED: Latimeria chalumnae alcohol dehydrogenase class-3-like (LOC102353852), mRNA K00121 frmA, ADH5, adhC S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00121 P79896 1475 5.8e-162 Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1 PF08240//PF02826//PF03721//PF00107 Alcohol dehydrogenase GroES-like domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0051287//GO:0016616 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG0022 Alcohol dehydrogenase, class III Cluster-8309.35215 BP_3 6224.96 689.30 727 91093619 XP_972048.1 469 2.0e-44 PREDICTED: 60S ribosomal protein L26 [Tribolium castaneum]>gi|270015756|gb|EFA12204.1| hypothetical protein TcasGA2_TC005120 [Tribolium castaneum] 70909792 AM049083.1 215 9.6436e-107 Curculio glandium mRNA for ribosomal protein L26e (rpL26e gene) K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P61254 391 8.9e-37 60S ribosomal protein L26 OS=Homo sapiens GN=RPL26 PE=1 SV=1 PF16906 Ribosomal proteins L26 eukaryotic, L24P archaeal GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG3401 60S ribosomal protein L26 Cluster-8309.35217 BP_3 735.00 18.78 2178 189241091 XP_001811274.1 1894 3.4e-209 PREDICTED: 4F2 cell-surface antigen heavy chain [Tribolium castaneum]>gi|270013351|gb|EFA09799.1| hypothetical protein TcasGA2_TC011942 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10852 254 2.0e-20 4F2 cell-surface antigen heavy chain OS=Mus musculus GN=Slc3a2 PE=1 SV=1 PF00128//PF00443 Alpha amylase, catalytic domain//Ubiquitin carboxyl-terminal hydrolase GO:0005975//GO:0016579 carbohydrate metabolic process//protein deubiquitination GO:0003824//GO:0036459//GO:0043169 catalytic activity//ubiquitinyl hydrolase activity//cation binding -- -- KOG0471 Alpha-amylase Cluster-8309.35218 BP_3 19.00 0.62 1773 669214630 CDW61305.1 238 2.9e-17 hypothetical protein TTRE_0000975601 [Trichuris trichiura] 56968029 AY859575.1 418 0 Gaetice depressus 5.8S ribosomal RNA gene, partial sequence; internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM6 197 6.8e-14 Protein TAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAR1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35219 BP_3 1025.42 15.66 3447 642921485 XP_966806.2 2283 4.2e-254 PREDICTED: uncharacterized protein LOC655197 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9S777 822 4.4e-86 4-coumarate--CoA ligase 3 OS=Arabidopsis thaliana GN=4CL3 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.35221 BP_3 12.00 1.37 715 194767015 XP_001965614.1 183 2.8e-11 GF22361 [Drosophila ananassae]>gi|190619605|gb|EDV35129.1| GF22361 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- D2WKD9 171 2.8e-11 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 -- -- GO:0008152 metabolic process -- -- -- -- -- -- Cluster-8309.35223 BP_3 302.28 2.93 5266 91082885 XP_971739.1 1098 1.6e-116 PREDICTED: leucine-rich repeat extensin-like protein 3 [Tribolium castaneum]>gi|270007607|gb|EFA04055.1| hypothetical protein TcasGA2_TC014287 [Tribolium castaneum] 642923275 XM_966646.2 63 2.28071e-21 PREDICTED: Tribolium castaneum leucine-rich repeat extensin-like protein 3 (LOC660415), mRNA -- -- -- -- Q9C0B9 157 8.8e-09 Zinc finger CCHC domain-containing protein 2 OS=Homo sapiens GN=ZCCHC2 PE=1 SV=6 PF00098//PF03608 Zinc knuckle//PTS system enzyme II sorbitol-specific factor GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.35225 BP_3 8579.28 402.93 1318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35227 BP_3 615.44 13.52 2486 546682338 ERL92286.1 1172 2.0e-125 hypothetical protein D910_09603 [Dendroctonus ponderosae] -- -- -- -- -- K15728 LPIN phosphatidate phosphatase LPIN http://www.genome.jp/dbget-bin/www_bget?ko:K15728 Q7TNN8 385 1.5e-35 Phosphatidate phosphatase LPIN3 OS=Mus spretus GN=Lpin3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2116 Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism Cluster-8309.35228 BP_3 223.91 10.12 1358 833654169 AKM28424.1 837 7.8e-87 fatty acid synthase 2 [Aphis gossypii] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 522 1.1e-51 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF16093//PF00975//PF00025 Proteasome assembly chaperone 4//Thioesterase domain//ADP-ribosylation factor family GO:0009058//GO:0043248 biosynthetic process//proteasome assembly GO:0016788//GO:0005525 hydrolase activity, acting on ester bonds//GTP binding -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.35229 BP_3 72.26 3.83 1200 546672885 ERL84608.1 1032 1.7e-109 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 859 7.9e-91 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00106//PF00107 short chain dehydrogenase//Zinc-binding dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.35231 BP_3 914.19 6.45 7118 270001906 EEZ98353.1 206 6.0e-13 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35232 BP_3 223.00 30.42 645 642920635 XP_008192497.1 153 7.6e-08 PREDICTED: cuticle protein 63 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35233 BP_3 48.69 0.69 3704 91083623 XP_970124.1 1221 6.3e-131 PREDICTED: probable citrate synthase 2, mitochondrial [Tribolium castaneum]>gi|270006831|gb|EFA03279.1| hypothetical protein TcasGA2_TC013214 [Tribolium castaneum] 332373859 BT127109.1 235 3.88798e-117 Dendroctonus ponderosae clone DPO016_K18 unknown mRNA K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q17GM7 1151 3.4e-124 Probable citrate synthase 1, mitochondrial OS=Aedes aegypti GN=AAEL002956 PE=3 SV=1 PF00285//PF01155//PF00096//PF01429//PF16622//PF03367//PF13912//PF01363//PF13465 Citrate synthase//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Methyl-CpG binding domain//zinc-finger C2H2-type//ZPR1 zinc-finger domain//C2H2-type zinc finger//FYVE zinc finger//Zinc-finger double domain GO:0046487//GO:0006464//GO:0006099//GO:0044262 glyoxylate metabolic process//cellular protein modification process//tricarboxylic acid cycle//cellular carbohydrate metabolic process GO:0016151//GO:0046912//GO:0003677//GO:0004108//GO:0046872//GO:0008270 nickel cation binding//transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer//DNA binding//citrate (Si)-synthase activity//metal ion binding//zinc ion binding GO:0005634 nucleus KOG2617 Citrate synthase Cluster-8309.35234 BP_3 252.29 5.15 2651 91076170 XP_971503.1 2162 3.5e-240 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 401 0 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 503 3.3e-49 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.35235 BP_3 294.71 3.38 4491 91083703 XP_969630.1 2122 2.5e-235 PREDICTED: monocarboxylate transporter 5 [Tribolium castaneum]>gi|270007880|gb|EFA04328.1| hypothetical protein TcasGA2_TC014622 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GM59 412 2.0e-38 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.35236 BP_3 1914.00 32.05 3170 478250492 ENN70987.1 2095 2.4e-232 hypothetical protein YQE_12387, partial [Dendroctonus ponderosae] 332372497 BT126427.1 262 3.25219e-132 Dendroctonus ponderosae clone DPO016_I09 unknown mRNA K06272 ILK integrin-linked kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06272 Q5R5V4 1513 3.1e-166 Integrin-linked protein kinase OS=Pongo abelii GN=ILK PE=2 SV=1 PF13606//PF07714//PF00023//PF00069 Ankyrin repeat//Protein tyrosine kinase//Ankyrin repeat//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- KOG0195 Integrin-linked kinase Cluster-8309.35237 BP_3 2492.13 12.01 10295 270001965 EEZ98412.1 2469 3.4e-275 hypothetical protein TcasGA2_TC000880 [Tribolium castaneum] 551500202 XM_005801594.1 175 2.45492e-83 PREDICTED: Xiphophorus maculatus zinc finger MIZ domain-containing protein 1-like (LOC102237688), mRNA -- -- -- -- Q6P1E1 1311 2.6e-142 Zinc finger MIZ domain-containing protein 1 OS=Mus musculus GN=Zmiz1 PE=2 SV=1 PF11789//PF03917//PF03199//PF02891 Zinc-finger of the MIZ type in Nse subunit//Eukaryotic glutathione synthase, ATP binding domain//Eukaryotic glutathione synthase//MIZ/SP-RING zinc finger GO:0006750 glutathione biosynthetic process GO:0004363//GO:0005524//GO:0008270 glutathione synthase activity//ATP binding//zinc ion binding -- -- KOG0021 Glutathione synthetase Cluster-8309.35238 BP_3 154.27 0.81 9446 642911235 XP_008199694.1 6755 0.0e+00 PREDICTED: laminin subunit beta-1 [Tribolium castaneum] 198455549 XM_001360008.2 44 1.49629e-10 Drosophila pseudoobscura pseudoobscura GA20347 (Dpse\GA20347), partial mRNA K05636 LAMB1 laminin, beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05636 P11046 4487 0.0e+00 Laminin subunit beta-1 OS=Drosophila melanogaster GN=LanB1 PE=1 SV=4 PF03523//PF00874//PF05384//PF01133//PF00089//PF05007//PF10440//PF03554 Macrophage scavenger receptor//PRD domain//Sensor protein DegS//Enhancer of rudimentary//Trypsin//Mannosyltransferase (PIG-M)//Ubiquitin-binding WIYLD domain//UL73 viral envelope glycoprotein GO:0006479//GO:0006506//GO:0006508//GO:0006221//GO:0006898//GO:0007049//GO:0006554//GO:0006355//GO:0007165//GO:0045747 protein methylation//GPI anchor biosynthetic process//proteolysis//pyrimidine nucleotide biosynthetic process//receptor-mediated endocytosis//cell cycle//lysine catabolic process//regulation of transcription, DNA-templated//signal transduction//positive regulation of Notch signaling pathway GO:0018024//GO:0005044//GO:0004252//GO:0016301//GO:0016758 histone-lysine N-methyltransferase activity//scavenger receptor activity//serine-type endopeptidase activity//kinase activity//transferase activity, transferring hexosyl groups GO:0016020//GO:0019031//GO:0016021 membrane//viral envelope//integral component of membrane KOG0994 Extracellular matrix glycoprotein Laminin subunit beta Cluster-8309.3524 BP_3 7.00 0.31 1376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35240 BP_3 175.59 2.18 4172 91080257 XP_973323.1 2311 2.9e-257 PREDICTED: T-complex protein 1 subunit delta [Tribolium castaneum]>gi|270005693|gb|EFA02141.1| hypothetical protein TcasGA2_TC007791 [Tribolium castaneum] 641791443 XM_005305637.2 106 2.25206e-45 PREDICTED: Chrysemys picta bellii chaperonin containing TCP1, subunit 4 (delta) (CCT4), mRNA K09496 CCT4 T-complex protein 1 subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K09496 Q9NB32 2088 8.5e-233 T-complex protein 1 subunit delta OS=Ochlerotatus triseriatus PE=2 SV=1 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding GO:0005737 cytoplasm KOG0358 Chaperonin complex component, TCP-1 delta subunit (CCT4) Cluster-8309.35241 BP_3 1115.70 47.08 1434 91078908 XP_967303.1 743 6.5e-76 PREDICTED: U1 small nuclear ribonucleoprotein 70 kDa [Tribolium castaneum]>gi|270003669|gb|EFA00117.1| hypothetical protein TcasGA2_TC002933 [Tribolium castaneum] 766937927 XM_011503139.1 112 3.52024e-49 PREDICTED: Ceratosolen solmsi marchali U1 small nuclear ribonucleoprotein 70 kDa-like (LOC105365059), mRNA K11093 SNRP70 U1 small nuclear ribonucleoprotein 70kDa http://www.genome.jp/dbget-bin/www_bget?ko:K11093 P17133 635 8.9e-65 U1 small nuclear ribonucleoprotein 70 kDa OS=Drosophila melanogaster GN=snRNP-U1-70K PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0097159//GO:0003676//GO:1901363 organic cyclic compound binding//nucleic acid binding//heterocyclic compound binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.35243 BP_3 142.00 13.47 800 642927327 XP_008195222.1 560 6.0e-55 PREDICTED: protein canopy homolog 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXT0 247 4.9e-20 Protein canopy homolog 2 OS=Mus musculus GN=Cnpy2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3782 Predicted membrane protein, contains type II SA sequence Cluster-8309.35244 BP_3 1039.86 10.06 5274 642930359 XP_008196365.1 725 2.9e-73 PREDICTED: protein DEK isoform X1 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.71562e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.35245 BP_3 2147.25 17.47 6217 546682799 ERL92688.1 323 1.4e-26 hypothetical protein D910_09999 [Dendroctonus ponderosae] -- -- -- -- -- K13189 RBM14 RNA-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13189 Q96PK6 166 9.4e-10 RNA-binding protein 14 OS=Homo sapiens GN=RBM14 PE=1 SV=2 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.35248 BP_3 31.02 1.24 1494 642933931 XP_008197572.1 565 3.0e-55 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 233 3.8e-18 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35249 BP_3 39.05 0.84 2534 270010086 EFA06534.1 365 7.8e-32 hypothetical protein TcasGA2_TC009438 [Tribolium castaneum] 565446497 XM_006284601.1 38 8.60783e-08 Capsella rubella hypothetical protein (CARUB_v10005922mg) mRNA, complete cds K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 Q9XSU4 349 2.3e-31 40S ribosomal protein S11 OS=Canis familiaris GN=RPS11 PE=1 SV=2 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.35250 BP_3 560.30 26.86 1297 478255948 ENN76149.1 612 9.1e-61 hypothetical protein YQE_07321, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35252 BP_3 1234.82 84.51 996 642914876 XP_008190427.1 634 2.0e-63 PREDICTED: tropomyosin alpha-1 chain [Tribolium castaneum]>gi|270001406|gb|EEZ97853.1| hypothetical protein TcasGA2_TC000225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O67124 133 1.0e-06 Probable DNA double-strand break repair Rad50 ATPase OS=Aquifex aeolicus (strain VF5) GN=rad50 PE=3 SV=1 PF08702//PF03936//PF06009 Fibrinogen alpha/beta chain family//Terpene synthase family, metal binding domain//Laminin Domain II GO:0007155//GO:0030168//GO:0051258//GO:0007165 cell adhesion//platelet activation//protein polymerization//signal transduction GO:0010333//GO:0016829//GO:0000287//GO:0030674//GO:0005102 terpene synthase activity//lyase activity//magnesium ion binding//protein binding, bridging//receptor binding GO:0005577 fibrinogen complex -- -- Cluster-8309.35253 BP_3 5106.26 41.98 6154 642928768 XP_008195553.1 4946 0.0e+00 PREDICTED: ATPase, class II, type 9B isoform X2 [Tribolium castaneum] 342356458 JF265057.1 79 3.40272e-30 Heliconius melpomene cythera ribosomal protein L29 (RpL29) mRNA, complete cds K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3572 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF00122//PF10473//PF01779 E1-E2 ATPase//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Ribosomal L29e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008134//GO:0045502//GO:0003735//GO:0042803//GO:0000166//GO:0046872 transcription factor binding//dynein binding//structural constituent of ribosome//protein homodimerization activity//nucleotide binding//metal ion binding GO:0030286//GO:0005667//GO:0005840//GO:0005622 dynein complex//transcription factor complex//ribosome//intracellular KOG0210 P-type ATPase Cluster-8309.35254 BP_3 144.95 0.74 9774 642924959 XP_008194115.1 2763 2.6e-309 PREDICTED: coiled-coil domain-containing protein CG32809 isoform X7 [Tribolium castaneum] 642924968 XM_008195898.1 229 2.23339e-113 PREDICTED: Tribolium castaneum coiled-coil domain-containing protein AGAP005037 (LOC100141714), transcript variant X12, mRNA -- -- -- -- Q7PQ25 1220 8.9e-132 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF15724//PF01025//PF07945//PF02970//PF07989 TMEM119 family//GrpE//Janus-atracotoxin//Tubulin binding cofactor A//Centrosomin N-terminal motif 1 GO:0007021//GO:0009405//GO:0001503//GO:0006457 tubulin complex assembly//pathogenesis//ossification//protein folding GO:0051087//GO:0042803//GO:0051082//GO:0000774//GO:0015631 chaperone binding//protein homodimerization activity//unfolded protein binding//adenyl-nucleotide exchange factor activity//tubulin binding GO:0005576//GO:0005815//GO:0045298 extracellular region//microtubule organizing center//tubulin complex -- -- Cluster-8309.35255 BP_3 48.90 1.39 1992 270013360 EFA09808.1 1271 5.4e-137 hypothetical protein TcasGA2_TC011953 [Tribolium castaneum] -- -- -- -- -- K18624 MAEA, EMP macrophage erythroblast attacher http://www.genome.jp/dbget-bin/www_bget?ko:K18624 Q6GR10 861 7.7e-91 Macrophage erythroblast attacher OS=Xenopus laevis GN=maea PE=2 SV=2 PF06291//PF08513 Bor protein//LisH -- -- GO:0005515 protein binding GO:0009279 cell outer membrane KOG0396 Uncharacterized conserved protein Cluster-8309.35256 BP_3 3.00 11.43 272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35258 BP_3 1694.31 52.75 1840 642911947 XP_008199033.1 1184 6.1e-127 PREDICTED: phospholipid scramblase 2 isoform X1 [Tribolium castaneum] 462310482 APGK01047306.1 73 2.17376e-27 Dendroctonus ponderosae Seq01047316, whole genome shotgun sequence -- -- -- -- O15162 796 2.5e-83 Phospholipid scramblase 1 OS=Homo sapiens GN=PLSCR1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0621 Phospholipid scramblase Cluster-8309.35259 BP_3 199.87 5.31 2107 91084421 XP_968215.1 1625 5.1e-178 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 980 1.3e-104 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326//PF06467 alpha/beta hydrolase fold//Prolyl oligopeptidase family//MYM-type Zinc finger with FCS sequence motif GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008270//GO:0016787//GO:0008236 zinc ion binding//hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.35261 BP_3 359.75 5.38 3516 642930868 XP_008196118.1 1543 2.7e-168 PREDICTED: homeobox protein PKNOX2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96KN3 713 2.0e-73 Homeobox protein PKNOX2 OS=Homo sapiens GN=PKNOX2 PE=2 SV=2 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.35262 BP_3 5386.96 287.46 1195 270014475 EFA10923.1 726 5.1e-74 hypothetical protein TcasGA2_TC001749 [Tribolium castaneum] -- -- -- -- -- K15410 EEF1D elongation factor 1-delta http://www.genome.jp/dbget-bin/www_bget?ko:K15410 Q9VL18 494 1.7e-48 Probable elongation factor 1-delta OS=Drosophila melanogaster GN=eEF1delta PE=1 SV=1 PF00736//PF00958//PF08702//PF02346//PF10152//PF06009 EF-1 guanine nucleotide exchange domain//GMP synthase C terminal domain//Fibrinogen alpha/beta chain family//Chordopoxvirus multifunctional envelope protein A27//Predicted coiled-coil domain-containing protein (DUF2360)//Laminin Domain II GO:0030168//GO:0007155//GO:0019064//GO:0006144//GO:0006177//GO:0006414//GO:0007165//GO:0006536//GO:0006448//GO:0051258//GO:0006164 platelet activation//cell adhesion//fusion of virus membrane with host plasma membrane//purine nucleobase metabolic process//GMP biosynthetic process//translational elongation//signal transduction//glutamate metabolic process//regulation of translational elongation//protein polymerization//purine nucleotide biosynthetic process GO:0003922//GO:0003746//GO:0030674//GO:0005102//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//translation elongation factor activity//protein binding, bridging//receptor binding//ATP binding GO:0005853//GO:0019031//GO:0005840//GO:0005577//GO:0071203 eukaryotic translation elongation factor 1 complex//viral envelope//ribosome//fibrinogen complex//WASH complex KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.35263 BP_3 33.69 11.29 435 264667463 ACY71317.1 400 1.2e-36 ribosomal protein L22 [Chrysomela tremula] -- -- -- -- -- K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 233 1.1e-18 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3434 60S ribosomal protein L22 Cluster-8309.35266 BP_3 9.58 1.61 578 91090912 XP_973979.1 533 5.9e-52 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] 642936036 XM_968886.2 117 2.27512e-52 PREDICTED: Tribolium castaneum troponin C, isoform 2 (LOC662809), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47948 487 5.2e-48 Troponin C, isoform 2 OS=Drosophila melanogaster GN=TpnC47D PE=2 SV=2 PF12763//PF13202//PF13499//PF00036//PF13833//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35270 BP_3 25.57 0.43 3190 642913783 XP_008201159.1 2257 4.0e-251 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 1.05575e-27 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 2053 7.4e-229 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF00413//PF10462 Matrixin//Peptidase M66 GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.35271 BP_3 641.75 75.21 703 91091878 XP_969758.1 559 6.9e-55 PREDICTED: von Willebrand factor D and EGF domain-containing protein [Tribolium castaneum]>gi|270001301|gb|EEZ97748.1| nimrod B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2E2 169 4.8e-11 von Willebrand factor D and EGF domain-containing protein OS=Homo sapiens GN=VWDE PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35272 BP_3 646.00 40.11 1068 91080521 XP_971959.1 1127 1.4e-120 PREDICTED: 26S proteasome non-ATPase regulatory subunit 8 [Tribolium castaneum]>gi|270005781|gb|EFA02229.1| hypothetical protein TcasGA2_TC007891 [Tribolium castaneum] -- -- -- -- -- K03031 PSMD8, RPN12 26S proteasome regulatory subunit N12 http://www.genome.jp/dbget-bin/www_bget?ko:K03031 Q9CX56 784 3.5e-82 26S proteasome non-ATPase regulatory subunit 8 OS=Mus musculus GN=Psmd8 PE=1 SV=2 -- -- GO:0006508 proteolysis -- -- GO:0005838 proteasome regulatory particle KOG3151 26S proteasome regulatory complex, subunit RPN12/PSMD8 Cluster-8309.35273 BP_3 15.00 2.86 544 47939570 AAH71804.1 663 4.6e-67 IGL@ protein [Homo sapiens] 47939569 BC071804.1 509 0 Homo sapiens immunoglobulin lambda locus, mRNA (cDNA clone MGC:88451 IMAGE:4717660), complete cds K06554 IGLL1, IGLL immunoglobulin lambda-like polypeptide 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06554 B9A064 581 6.1e-59 Immunoglobulin lambda-like polypeptide 5 OS=Homo sapiens GN=IGLL5 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35274 BP_3 322.92 8.12 2208 642934520 XP_001812516.2 603 1.7e-59 PREDICTED: tetraspanin-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.35275 BP_3 19.65 0.49 2209 91084421 XP_968215.1 1568 2.2e-171 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 889 4.9e-94 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF06467//PF07859//PF00326 MYM-type Zinc finger with FCS sequence motif//alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008270//GO:0008236 hydrolase activity//zinc ion binding//serine-type peptidase activity -- -- -- -- Cluster-8309.35276 BP_3 16456.76 777.45 1312 91086095 XP_967348.1 1672 1.1e-183 PREDICTED: tubulin beta chain [Tribolium castaneum]>gi|270010216|gb|EFA06664.1| hypothetical protein TcasGA2_TC009590 [Tribolium castaneum] 571525023 XM_394469.4 429 0 PREDICTED: Apis mellifera beta-Tubulin at 60D ortholog (LOC410994), transcript variant 2, mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 P08841 1594 5.1e-176 Tubulin beta-3 chain OS=Drosophila melanogaster GN=betaTub60D PE=2 SV=2 PF00091 Tubulin/FtsZ family, GTPase domain GO:0006184//GO:0007018//GO:0051258 obsolete GTP catabolic process//microtubule-based movement//protein polymerization GO:0005525//GO:0005198//GO:0003924 GTP binding//structural molecule activity//GTPase activity GO:0005737//GO:0005874 cytoplasm//microtubule KOG1375 Beta tubulin Cluster-8309.35277 BP_3 2683.58 142.57 1199 815806339 XP_012223941.1 578 7.4e-57 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105673125 [Linepithema humile] 642916990 XM_967678.2 232 5.74215e-116 PREDICTED: Tribolium castaneum protein translation factor SUI1 homolog (LOC661525), mRNA K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 P42678 546 1.6e-54 Protein translation factor SUI1 homolog OS=Anopheles gambiae GN=AGAP006459 PE=3 SV=1 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.35278 BP_3 219.75 11.37 1223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35279 BP_3 122.87 5.58 1353 642928322 XP_008195533.1 577 1.1e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.0e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.3528 BP_3 2.16 0.98 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35284 BP_3 516.05 8.83 3108 332375280 AEE62781.1 763 6.8e-78 unknown [Dendroctonus ponderosae]>gi|478256834|gb|ENN77009.1| hypothetical protein YQE_06503, partial [Dendroctonus ponderosae] 642913881 XM_970098.2 182 9.44612e-88 PREDICTED: Tribolium castaneum dnaJ homolog subfamily C member 8 (LOC664081), mRNA K09528 DNAJC8 DnaJ homolog subfamily C member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09528 Q6NZB0 496 2.5e-48 DnaJ homolog subfamily C member 8 OS=Mus musculus GN=Dnajc8 PE=2 SV=2 PF12537//PF06963 The Golgi pH Regulator (GPHR) Family N-terminal//Ferroportin1 (FPN1) GO:0006826//GO:0034755 iron ion transport//iron ion transmembrane transport GO:0005381 iron ion transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1150 Predicted molecular chaperone (DnaJ superfamily) Cluster-8309.35285 BP_3 1041.00 19.85 2820 642918411 XP_008191461.1 3094 0.0e+00 PREDICTED: AFG3-like protein 2 [Tribolium castaneum]>gi|270003255|gb|EEZ99702.1| hypothetical protein TcasGA2_TC002463 [Tribolium castaneum] 815902633 XM_003487018.2 362 0 PREDICTED: Bombus impatiens AFG3-like protein 2 (LOC100740165), mRNA K08956 AFG3 AFG3 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K08956 Q9Y4W6 2279 4.1e-255 AFG3-like protein 2 OS=Homo sapiens GN=AFG3L2 PE=1 SV=2 PF01695//PF07728//PF05496//PF06480//PF06068//PF00004//PF01434//PF07724 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//FtsH Extracellular//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Peptidase family M41//AAA domain (Cdc48 subfamily) GO:0030163//GO:0006508//GO:0006310//GO:0006281 protein catabolic process//proteolysis//DNA recombination//DNA repair GO:0017111//GO:0009378//GO:0016887//GO:0008270//GO:0003678//GO:0005524//GO:0004222 nucleoside-triphosphatase activity//four-way junction helicase activity//ATPase activity//zinc ion binding//DNA helicase activity//ATP binding//metalloendopeptidase activity GO:0016021//GO:0009379//GO:0005657 integral component of membrane//Holliday junction helicase complex//replication fork KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.35286 BP_3 180.94 6.36 1663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF08119 Arthropod defensin//Scorpion acidic alpha-KTx toxin family GO:0006952//GO:0006810//GO:0009405 defense response//transport//pathogenesis GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.35287 BP_3 6.00 0.60 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02788 Ribulose bisphosphate carboxylase large chain, N-terminal domain GO:0015977//GO:0046487 carbon fixation//glyoxylate metabolic process GO:0016984 ribulose-bisphosphate carboxylase activity GO:0009573 chloroplast ribulose bisphosphate carboxylase complex -- -- Cluster-8309.35288 BP_3 2757.90 17.26 7993 91084687 XP_968830.1 2631 4.3e-294 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] 831284033 XM_012817767.1 98 1.21264e-40 PREDICTED: Clupea harengus myotubularin-related protein 3-like (LOC105891591), mRNA K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q13615 1526 2.4e-167 Myotubularin-related protein 3 OS=Homo sapiens GN=MTMR3 PE=1 SV=3 PF00400//PF07646//PF10716//PF00782//PF01363//PF00102 WD domain, G-beta repeat//Kelch motif//NADH dehydrogenase transmembrane subunit//Dual specificity phosphatase, catalytic domain//FYVE zinc finger//Protein-tyrosine phosphatase GO:0006570//GO:0006470//GO:0006118//GO:0035335//GO:0055114 tyrosine metabolic process//protein dephosphorylation//obsolete electron transport//peptidyl-tyrosine dephosphorylation//oxidation-reduction process GO:0004725//GO:0008138//GO:0005515//GO:0046872//GO:0016655 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//metal ion binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.3529 BP_3 36.00 1.16 1791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00375 Sodium:dicarboxylate symporter family GO:0006812//GO:0006835//GO:0006820 cation transport//dicarboxylic acid transport//anion transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane -- -- Cluster-8309.35290 BP_3 146.71 2.44 3192 73921480 AAZ94270.1 1338 1.5e-144 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 902 2.2e-95 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0016705//GO:0005488 heme binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding -- -- -- -- Cluster-8309.35291 BP_3 64.76 1.54 2316 91090182 XP_966481.1 1041 2.9e-110 PREDICTED: methenyltetrahydrofolate synthase domain-containing protein [Tribolium castaneum]>gi|270013764|gb|EFA10212.1| hypothetical protein TcasGA2_TC012407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M296 578 5.9e-58 Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens GN=MTHFSD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4410 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.35292 BP_3 4762.06 115.62 2277 282848147 NP_001164292.1 1039 4.9e-110 kayak isoform A [Tribolium castaneum]>gi|270014251|gb|EFA10699.1| kayak [Tribolium castaneum] -- -- -- -- -- K09031 FOSLN fos-like antigen, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09031 B4K617 198 6.7e-14 Transcription factor kayak OS=Drosophila mojavensis GN=kay PE=3 SV=1 PF00170//PF07716//PF03131 bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.35293 BP_3 1797.53 10.21 8776 270003498 EEZ99945.1 2824 0.0e+00 hypothetical protein TcasGA2_TC002741 [Tribolium castaneum] -- -- -- -- -- K12316 GAA lysosomal alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12316 Q6P7A9 1834 5.1e-203 Lysosomal alpha-glucosidase OS=Rattus norvegicus GN=Gaa PE=2 SV=1 PF13465//PF00096//PF01055//PF02892//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Glycosyl hydrolases family 31//BED zinc finger//C2H2-type zinc finger GO:0005975 carbohydrate metabolic process GO:0046872//GO:0004553//GO:0003677 metal ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding -- -- -- -- Cluster-8309.35294 BP_3 12397.97 1596.54 666 264667421 ACY71296.1 1011 2.5e-107 ribosomal protein L13A [Chrysomela tremula] -- -- -- -- -- K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 Q962U0 866 6.8e-92 60S ribosomal protein L13a OS=Spodoptera frugiperda GN=RpL13A PE=2 SV=1 PF00707//PF00572 Translation initiation factor IF-3, C-terminal domain//Ribosomal protein L13 GO:0042254//GO:0006412//GO:0006413 ribosome biogenesis//translation//translational initiation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-8309.35296 BP_3 110.25 2.11 2816 642914766 XP_008190343.1 509 1.7e-48 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N2D1 239 1.5e-18 Tryptase OS=Sus scrofa GN=MCT7 PE=2 SV=1 PF00089//PF00647//PF03609 Trypsin//Elongation factor 1 gamma, conserved domain//PTS system sorbose-specific iic component GO:0006414//GO:0006448//GO:0009401//GO:0006508 translational elongation//regulation of translational elongation//phosphoenolpyruvate-dependent sugar phosphotransferase system//proteolysis GO:0003746//GO:0004252 translation elongation factor activity//serine-type endopeptidase activity GO:0016021//GO:0005840 integral component of membrane//ribosome -- -- Cluster-8309.35297 BP_3 683.80 108.30 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35298 BP_3 550.63 16.54 1896 270013857 EFA10305.1 208 9.4e-14 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13181 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35299 BP_3 374.00 10.58 1995 546679644 ERL90075.1 699 1.1e-70 hypothetical protein D910_07430, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPK7 278 3.1e-23 Lateral signaling target protein 2 homolog OS=Mus musculus GN=Zfyve28 PE=1 SV=2 PF07127//PF00643//PF01363//PF16622//PF00320 Late nodulin protein//B-box zinc finger//FYVE zinc finger//zinc-finger C2H2-type//GATA zinc finger GO:0006355//GO:0009878 regulation of transcription, DNA-templated//nodule morphogenesis GO:0043565//GO:0008270//GO:0003700//GO:0046872 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0005667//GO:0005622 transcription factor complex//intracellular -- -- Cluster-8309.3530 BP_3 6.00 0.76 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35301 BP_3 635.09 47.15 941 288860140 NP_001165842.1 638 6.4e-64 uracil-DNA degrading factor [Tribolium castaneum]>gi|270002992|gb|EEZ99439.1| hypothetical protein TcasGA2_TC030651 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35305 BP_3 3340.17 26.69 6323 642918534 XP_008191512.1 3637 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7P4 637 2.3e-64 SEC14 domain and spectrin repeat-containing protein 1 OS=Xenopus tropicalis GN=sestd1 PE=2 SV=1 PF00435//PF00260//PF00536 Spectrin repeat//Protamine P1//SAM domain (Sterile alpha motif) GO:0007283 spermatogenesis GO:0003677//GO:0005515 DNA binding//protein binding GO:0000786//GO:0005634 nucleosome//nucleus KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.35307 BP_3 38.30 4.71 684 258643293 ACV86033.1 164 4.3e-09 neuropeptide F [Reticulitermes flavipes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35309 BP_3 12067.00 1206.00 774 264667423 ACY71297.1 979 1.5e-103 ribosomal protein L13 [Chrysomela tremula] 332373967 BT127163.1 183 6.33052e-89 Dendroctonus ponderosae clone DPO0813_M04 unknown mRNA K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 Q962U1 810 2.5e-85 60S ribosomal protein L13 OS=Spodoptera frugiperda GN=RpL13 PE=2 SV=1 PF01294 Ribosomal protein L13e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3295 60S Ribosomal protein L13 Cluster-8309.35310 BP_3 22374.36 1411.07 1056 91076896 XP_976237.1 1203 2.2e-129 PREDICTED: troponin T, skeletal muscle isoform X1 [Tribolium castaneum] 459668605 JX303047.1 36 4.55521e-07 Lutzomyia longipalpis isolate PanupC10 up (up) gene, partial cds >gnl|BL_ORD_ID|16415056 Lutzomyia longipalpis isolate PanupH11 up (up) gene, partial cds K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 P19351 1008 3.7e-108 Troponin T, skeletal muscle OS=Drosophila melanogaster GN=up PE=1 SV=3 PF00769//PF00992 Ezrin/radixin/moesin family//Troponin -- -- GO:0008092 cytoskeletal protein binding GO:0005737//GO:0005861//GO:0019898 cytoplasm//troponin complex//extrinsic component of membrane KOG3634 Troponin Cluster-8309.35311 BP_3 1557.00 43.22 2028 91090696 XP_974756.1 1055 6.1e-112 PREDICTED: transmembrane emp24 domain-containing protein A [Tribolium castaneum]>gi|270013945|gb|EFA10393.1| hypothetical protein TcasGA2_TC012624 [Tribolium castaneum] 755957621 XM_011305512.1 75 1.85544e-28 PREDICTED: Fopius arisanus transmembrane emp24 domain-containing protein 1 (LOC105266973), mRNA -- -- -- -- Q9CXE7 228 2.0e-17 Transmembrane emp24 domain-containing protein 5 OS=Mus musculus GN=Tmed5 PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.35312 BP_3 706.82 44.11 1064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35314 BP_3 65.32 0.47 6933 642911196 XP_008199563.1 2708 4.4e-303 PREDICTED: solute carrier family 12 member 4 isoform X1 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.25915e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2008 2.7e-223 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF03522//PF00324//PF13520 Solute carrier family 12//Amino acid permease//Amino acid permease GO:0003333//GO:0006811//GO:0055085//GO:0006865//GO:0006810 amino acid transmembrane transport//ion transport//transmembrane transport//amino acid transport//transport GO:0015171//GO:0005215 amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.35315 BP_3 97.22 1.74 2984 332376234 AEE63257.1 1256 4.4e-135 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02867 RP-L11, MRPL11, rplK large subunit ribosomal protein L11 http://www.genome.jp/dbget-bin/www_bget?ko:K02867 Q9VFJ2 440 7.6e-42 39S ribosomal protein L11, mitochondrial OS=Drosophila melanogaster GN=mRpL11 PE=1 SV=1 PF00298//PF01064//PF00106 Ribosomal protein L11, RNA binding domain//Activin types I and II receptor domain//short chain dehydrogenase GO:0042254//GO:0008152//GO:0007178//GO:0009069//GO:0016310//GO:0006412 ribosome biogenesis//metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway//serine family amino acid metabolic process//phosphorylation//translation GO:0003735//GO:0004675//GO:0016491 structural constituent of ribosome//transmembrane receptor protein serine/threonine kinase activity//oxidoreductase activity GO:0005840//GO:0016020 ribosome//membrane KOG3257 Mitochondrial/chloroplast ribosomal protein L11 Cluster-8309.35316 BP_3 2382.90 18.88 6374 642939200 XP_008200378.1 588 2.7e-57 PREDICTED: plasminogen activator inhibitor 1 RNA-binding protein-like, partial [Tribolium castaneum] 642933104 XM_008199038.1 222 1.13162e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA K13199 SERBP1 plasminogen activator inhibitor 1 RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13199 Q9CY58 185 6.0e-12 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006560//GO:0006420//GO:0006525 proline metabolic process//arginyl-tRNA aminoacylation//arginine metabolic process GO:0004814//GO:0000166//GO:0005524 arginine-tRNA ligase activity//nucleotide binding//ATP binding GO:0005737 cytoplasm KOG2945 Predicted RNA-binding protein Cluster-8309.35319 BP_3 2391.60 56.25 2341 91079178 XP_966498.1 760 1.1e-77 PREDICTED: vesicle-associated membrane protein-associated protein B [Tribolium castaneum]>gi|270003608|gb|EFA00056.1| hypothetical protein TcasGA2_TC002864 [Tribolium castaneum] 642916508 XM_961405.2 63 1.00592e-21 PREDICTED: Tribolium castaneum vesicle-associated membrane protein-associated protein B (LOC656484), mRNA K06096 VAPA vesicle-associated membrane protein-associated protein A http://www.genome.jp/dbget-bin/www_bget?ko:K06096 Q5R601 430 8.6e-41 Vesicle-associated membrane protein-associated protein A OS=Pongo abelii GN=VAPA PE=2 SV=2 PF00170//PF07716//PF08172//PF06005//PF06156//PF04111//PF04977 bZIP transcription factor//Basic region leucine zipper//CASP C terminal//Protein of unknown function (DUF904)//Protein of unknown function (DUF972)//Autophagy protein Apg6//Septum formation initiator GO:0006891//GO:0006914//GO:0006260//GO:0006355//GO:0043093//GO:0000917//GO:0007049 intra-Golgi vesicle-mediated transport//autophagy//DNA replication//regulation of transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0030173//GO:0005737 transcription factor complex//integral component of Golgi membrane//cytoplasm KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-8309.35320 BP_3 24.00 3.27 645 675368640 KFM61542.1 755 1.2e-77 60S ribosomal protein L13a, partial [Stegodyphus mimosarum] 264667056 FJ790491.1 216 2.36401e-107 Scylla paramamosain 60S ribosomal protein L13A mRNA, partial cds K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 Q8MUR4 679 3.2e-70 60S ribosomal protein L13a OS=Choristoneura parallela GN=RpL13A PE=2 SV=1 PF00572 Ribosomal protein L13 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-8309.35321 BP_3 67.47 0.42 7964 642911417 XP_008199414.1 498 9.3e-47 PREDICTED: arrestin domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35322 BP_3 261.00 7.73 1920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35323 BP_3 12397.63 2812.85 504 91094863 XP_972456.1 324 8.8e-28 PREDICTED: 60S acidic ribosomal protein P1 [Tribolium castaneum]>gi|270006544|gb|EFA02992.1| hypothetical protein TcasGA2_TC010413 [Tribolium castaneum] 642922948 XM_967363.3 121 1.17754e-54 PREDICTED: Tribolium castaneum 60S acidic ribosomal protein P1 (LOC661185), mRNA K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P08570 303 9.9e-27 60S acidic ribosomal protein P1 OS=Drosophila melanogaster GN=RpLP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1762 60s acidic ribosomal protein P1 Cluster-8309.35325 BP_3 1658.91 7.22 11371 642933491 XP_008197440.1 3273 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 211 2.63674e-103 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1887 4.7e-209 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain GO:0008152 metabolic process GO:0003824//GO:0019843//GO:0003723 catalytic activity//rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.35326 BP_3 416.37 9.00 2522 270004278 EFA00726.1 492 1.5e-46 hypothetical protein TcasGA2_TC003607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35327 BP_3 43.52 0.80 2912 642916650 XP_008192038.1 492 1.7e-46 PREDICTED: uncharacterized protein LOC103312652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35328 BP_3 1922.49 32.12 3177 270001643 EEZ98090.1 515 4.0e-49 hypothetical protein TcasGA2_TC000503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01290//PF16074 Thymosin beta-4 family//Type IV Pilus-assembly protein W GO:0007015//GO:0043683 actin filament organization//type IV pilus biogenesis GO:0003785 actin monomer binding -- -- KOG4794 Thymosin beta Cluster-8309.35329 BP_3 47.07 1.06 2426 91091864 XP_968949.1 505 4.4e-48 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [Tribolium castaneum]>gi|270001295|gb|EEZ97742.1| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 [Tribolium castaneum] -- -- -- -- -- K03964 NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03964 Q02372 211 2.2e-15 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Bos taurus GN=NDUFB8 PE=1 SV=1 PF04839//PF05821 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)//NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) GO:0015992//GO:0042254//GO:0006814//GO:0006118//GO:0006744//GO:0006412//GO:0006120 proton transport//ribosome biogenesis//sodium ion transport//obsolete electron transport//ubiquinone biosynthetic process//translation//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003735//GO:0003954 NADH dehydrogenase (ubiquinone) activity//structural constituent of ribosome//NADH dehydrogenase activity GO:0005739//GO:0005840 mitochondrion//ribosome -- -- Cluster-8309.35330 BP_3 150.71 4.85 1790 91091864 XP_968949.1 505 3.2e-48 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [Tribolium castaneum]>gi|270001295|gb|EEZ97742.1| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 [Tribolium castaneum] -- -- -- -- -- K03964 NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03964 Q02372 211 1.6e-15 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Bos taurus GN=NDUFB8 PE=1 SV=1 PF05821//PF04839 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)//Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) GO:0006120//GO:0006412//GO:0006744//GO:0006118//GO:0006814//GO:0042254//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//translation//ubiquinone biosynthetic process//obsolete electron transport//sodium ion transport//ribosome biogenesis//proton transport GO:0003954//GO:0003735//GO:0008137 NADH dehydrogenase activity//structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity GO:0005840//GO:0005739 ribosome//mitochondrion -- -- Cluster-8309.35332 BP_3 10.66 0.31 1957 642919693 XP_008192024.1 250 1.3e-18 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H9B1 133 2.0e-06 Histone-lysine N-methyltransferase EHMT1 OS=Homo sapiens GN=EHMT1 PE=1 SV=4 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35333 BP_3 852.60 12.02 3711 642919693 XP_008192024.1 1421 4.1e-154 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 597 5.9e-60 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF00520//PF00023//PF10716//PF13606 Ion transport protein//Ankyrin repeat//NADH dehydrogenase transmembrane subunit//Ankyrin repeat GO:0006118//GO:0006811//GO:0055114//GO:0055085 obsolete electron transport//ion transport//oxidation-reduction process//transmembrane transport GO:0005216//GO:0016655//GO:0005515 ion channel activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//protein binding GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.35334 BP_3 2523.51 47.07 2876 478262395 ENN81066.1 2644 4.8e-296 hypothetical protein YQE_02435, partial [Dendroctonus ponderosae]>gi|546673615|gb|ERL85179.1| hypothetical protein D910_02601 [Dendroctonus ponderosae] 807040070 XM_004535125.2 159 5.33065e-75 PREDICTED: Ceratitis capitata plastin-3 (LOC101457045), transcript variant X2, mRNA K17336 PLS3 plastin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K17336 P13796 1474 9.2e-162 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=6 PF13499//PF13833//PF00036//PF13405//PF00307//PF04608//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Calponin homology (CH) domain//Phosphatidylglycerophosphatase A//EF hand GO:0006629//GO:0046486 lipid metabolic process//glycerolipid metabolic process GO:0008962//GO:0005515//GO:0005509 phosphatidylglycerophosphatase activity//protein binding//calcium ion binding -- -- KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily Cluster-8309.35335 BP_3 102.57 0.82 6321 642912779 XP_008201247.1 4231 0.0e+00 PREDICTED: chaoptin isoform X1 [Tribolium castaneum] 759065584 XM_011343927.1 47 2.14792e-12 PREDICTED: Cerapachys biroi homeobox protein Hox-B1a-like (LOC105282160), mRNA -- -- -- -- P12024 3007 0.0e+00 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00046//PF13855//PF00560 Homeobox domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.35337 BP_3 61.42 9.96 589 91078888 XP_973143.1 409 1.4e-37 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 O55173 294 1.3e-25 3-phosphoinositide-dependent protein kinase 1 OS=Rattus norvegicus GN=Pdpk1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.35338 BP_3 43.42 0.74 3121 91078888 XP_973143.1 1226 1.4e-131 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 Q9Z2A0 831 3.6e-87 3-phosphoinositide-dependent protein kinase 1 OS=Mus musculus GN=Pdpk1 PE=1 SV=2 PF06293//PF00069//PF07714//PF05445 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004674//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.35339 BP_3 20.78 0.93 1366 91090290 XP_971485.1 939 1.2e-98 PREDICTED: bax inhibitor 1 [Tribolium castaneum]>gi|270013796|gb|EFA10244.1| hypothetical protein TcasGA2_TC012443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7R1 567 6.5e-57 Bax inhibitor 1 OS=Pongo abelii GN=TMBIM6 PE=2 SV=2 -- -- GO:0043066 negative regulation of apoptotic process -- -- GO:0016021 integral component of membrane KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1 Cluster-8309.35341 BP_3 84.01 3.48 1457 189237643 XP_966949.2 744 5.1e-76 PREDICTED: diphthine synthase [Tribolium castaneum] -- -- -- -- -- K00586 DPH5 diphthine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00586 Q9H2P9 611 5.5e-62 Diphthine methyl ester synthase OS=Homo sapiens GN=DPH5 PE=1 SV=2 PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG3123 Diphthine synthase Cluster-8309.35343 BP_3 21.25 0.32 3483 546678570 ERL89159.1 871 2.3e-90 hypothetical protein D910_06534 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome -- -- Cluster-8309.35345 BP_3 354.61 11.72 1750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35346 BP_3 525.24 8.76 3183 149588751 NP_001092296.1 2699 2.2e-302 fused lobes [Tribolium castaneum]>gi|642928772|ref|XP_008195555.1| PREDICTED: fused lobes isoform X1 [Tribolium castaneum]>gi|148611482|gb|ABQ95985.1| beta-N-acetylglucosaminidase FDL [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 1351 1.9e-147 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975//GO:0006027//GO:0001575//GO:0006040 carbohydrate metabolic process//glycosaminoglycan catabolic process//globoside metabolic process//amino sugar metabolic process GO:0004563//GO:0004553//GO:0043169 beta-N-acetylhexosaminidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.35347 BP_3 1536.11 24.94 3261 589060796 AHK26791.1 476 1.4e-44 eukaryotic translation initiation factor 4A [Epicauta chinensis] 630969033 XM_007882734.1 83 1.07191e-32 Pseudozyma flocculosa PF-1 hypothetical protein partial mRNA K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 P29562 433 5.4e-41 Eukaryotic initiation factor 4A-I (Fragment) OS=Oryctolagus cuniculus GN=EIF4A1 PE=1 SV=2 PF00579 tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.35348 BP_3 4931.00 418.24 860 332372622 AEE61453.1 460 2.5e-43 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P82120 144 4.6e-08 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.35349 BP_3 50.66 1.37 2073 642912671 XP_969018.2 1631 1.0e-178 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 P28039 1000 6.1e-107 Acyloxyacyl hydrolase OS=Homo sapiens GN=AOAH PE=1 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.35350 BP_3 121.24 2.75 2413 282165788 NP_001164133.1 1259 1.6e-135 scavenger receptor protein [Tribolium castaneum]>gi|270009221|gb|EFA05669.1| hypothetical protein TcasGA2_TC014951 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61009 503 3.0e-49 Scavenger receptor class B member 1 OS=Mus musculus GN=Scarb1 PE=1 SV=1 PF01130//PF04790 CD36 family//Sarcoglycan complex subunit protein GO:0007155 cell adhesion -- -- GO:0016020//GO:0016021//GO:0016012 membrane//integral component of membrane//sarcoglycan complex -- -- Cluster-8309.35351 BP_3 98.99 1.43 3618 546672307 ERL84230.1 1819 2.8e-200 hypothetical protein D910_01607 [Dendroctonus ponderosae]>gi|546672574|gb|ERL84383.1| hypothetical protein D910_01813 [Dendroctonus ponderosae] 642933834 XM_008192574.1 146 1.13305e-67 PREDICTED: Tribolium castaneum leucine-rich repeat-containing protein let-4 (LOC659033), mRNA -- -- -- -- Q8R5M3 339 4.7e-30 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00322//PF00560 Leucine rich repeat//Endothelin family//Leucine Rich Repeat GO:0019229 regulation of vasoconstriction GO:0005515 protein binding GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.35352 BP_3 2117.27 63.41 1901 817216800 XP_012284405.1 719 5.2e-73 PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus]>gi|817216802|ref|XP_012284407.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q9TU03 480 1.1e-46 Rho GDP-dissociation inhibitor 2 OS=Bos taurus GN=ARHGDIB PE=2 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.35353 BP_3 28.02 0.92 1752 91088233 XP_973769.1 723 1.7e-73 PREDICTED: elongation factor 1-beta' [Tribolium castaneum]>gi|270011822|gb|EFA08270.1| hypothetical protein TcasGA2_TC005900 [Tribolium castaneum] -- -- -- -- -- K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 P29522 600 1.2e-60 Elongation factor 1-beta' OS=Bombyx mori PE=1 SV=2 PF05209//PF00736 Septum formation inhibitor MinC, N-terminal domain//EF-1 guanine nucleotide exchange domain GO:0006414//GO:0051302//GO:0006448//GO:0006412 translational elongation//regulation of cell division//regulation of translational elongation//translation GO:0003746 translation elongation factor activity GO:0005853//GO:0005840 eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.35355 BP_3 2301.72 27.24 4365 157111458 XP_001651573.1 1004 1.1e-105 AAEL005895-PA [Aedes aegypti]>gi|108878342|gb|EAT42567.1| AAEL005895-PA [Aedes aegypti] 462380259 APGK01022394.1 40 1.15235e-08 Dendroctonus ponderosae Seq01022404, whole genome shotgun sequence K04520 APP amyloid beta A4 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04520 P14599 928 2.9e-98 Beta-amyloid-like protein OS=Drosophila melanogaster GN=Appl PE=1 SV=2 PF02177//PF12924 Amyloid A4 N-terminal heparin-binding//Copper-binding of amyloid precursor, CuBD -- -- GO:0046914//GO:0008201 transition metal ion binding//heparin binding GO:0016021 integral component of membrane KOG3540 Beta amyloid precursor protein Cluster-8309.35357 BP_3 1282.92 29.47 2390 642915594 XP_008190680.1 1174 1.1e-125 PREDICTED: uncharacterized protein LOC655748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35358 BP_3 2051.97 36.65 2990 642926574 XP_008194926.1 2179 4.2e-242 PREDICTED: scavenger receptor class B member 1 isoform X2 [Tribolium castaneum] 826494758 XM_012685372.1 98 4.50386e-41 PREDICTED: Monomorium pharaonis scavenger receptor class B member 1 (LOC105839216), mRNA -- -- -- -- O18824 708 6.4e-73 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.35359 BP_3 323.59 1.49 10738 642935263 XP_008197938.1 6738 0.0e+00 PREDICTED: hemocytin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98092 3367 0.0e+00 Hemocytin OS=Bombyx mori PE=2 SV=1 PF05805//PF11051//PF00093//PF05375 L6 membrane protein//Mannosyltransferase putative//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) GO:0006486 protein glycosylation GO:0016757//GO:0005515//GO:0030414 transferase activity, transferring glycosyl groups//protein binding//peptidase inhibitor activity GO:0016021 integral component of membrane -- -- Cluster-8309.35361 BP_3 18.20 5.17 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35362 BP_3 337.57 7.78 2384 91079999 XP_966589.1 1804 1.0e-198 PREDICTED: kelch domain-containing protein 4 [Tribolium castaneum]>gi|270003222|gb|EEZ99669.1| hypothetical protein TcasGA2_TC002426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q921I2 1056 2.3e-113 Kelch domain-containing protein 4 OS=Mus musculus GN=Klhdc4 PE=2 SV=2 PF07646//PF01344 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG1230 Protein containing repeated kelch motifs Cluster-8309.35363 BP_3 32.79 3.96 691 270016290 EFA12736.1 180 6.0e-11 hypothetical protein TcasGA2_TC002373 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35364 BP_3 162.55 2.76 3133 642918280 XP_008191442.1 3580 0.0e+00 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 195430887 XM_002063444.1 409 0 Drosophila willistoni GK21381 (Dwil\GK21381), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 3025 0.0e+00 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 PF13371//PF13374//PF02259//PF00515//PF13414//PF13176//PF13181//PF05009//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat GO:0016032 viral process GO:0005515 protein binding GO:0042025 host cell nucleus KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.35365 BP_3 39.94 1.34 1725 270297202 NP_001161902.1 1685 4.6e-185 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 1313 2.6e-143 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- GO:0008152 metabolic process GO:0033961 cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.35366 BP_3 37.08 0.38 4938 642939097 XP_008200220.1 2017 4.2e-223 PREDICTED: uncharacterized protein LOC658083 isoform X1 [Tribolium castaneum]>gi|642939099|ref|XP_008200221.1| PREDICTED: uncharacterized protein LOC658083 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 867 3.9e-91 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 PF00993 Class II histocompatibility antigen, alpha domain GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- GO:0016020//GO:0042613 membrane//MHC class II protein complex KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.35367 BP_3 281.90 5.31 2849 642918282 XP_008191443.1 388 1.9e-34 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X2 [Tribolium castaneum] -- -- -- -- -- K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 371 7.3e-34 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.35368 BP_3 51.77 2.03 1523 642933525 XP_008197455.1 904 1.5e-94 PREDICTED: protein alan shepard isoform X2 [Tribolium castaneum] 462283408 APGK01056946.1 55 1.81753e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 4.4e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF09726//PF01080//PF07267//PF00076 Transmembrane protein//Presenilin//Nucleopolyhedrovirus capsid protein P87//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4733 FOG: RRM domain Cluster-8309.35369 BP_3 1432.40 21.66 3479 189241841 XP_001807104.1 2470 8.7e-276 PREDICTED: sodium/hydrogen exchanger 8 [Tribolium castaneum]>gi|270015694|gb|EFA12142.1| hypothetical protein TcasGA2_TC002289 [Tribolium castaneum] 642937940 XM_001807052.2 559 0 PREDICTED: Tribolium castaneum sodium/hydrogen exchanger 8 (LOC100141996), mRNA K14724 SLC9A8, NHE8 solute carrier family 9 (sodium/hydrogen exchanger), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14724 Q5ZJ75 1474 1.1e-161 Sodium/hydrogen exchanger 8 OS=Gallus gallus PE=2 SV=1 PF02615//PF00999 Malate/L-lactate dehydrogenase//Sodium/hydrogen exchanger family GO:0015992//GO:0055114//GO:0006812//GO:0006814//GO:0006885//GO:0008152//GO:0055085 proton transport//oxidation-reduction process//cation transport//sodium ion transport//regulation of pH//metabolic process//transmembrane transport GO:0016491//GO:0015385//GO:0015299 oxidoreductase activity//sodium:proton antiporter activity//solute:proton antiporter activity GO:0016021 integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.35370 BP_3 577.00 28.06 1283 478252243 ENN72671.1 1294 7.5e-140 hypothetical protein YQE_10769, partial [Dendroctonus ponderosae]>gi|546675736|gb|ERL86868.1| hypothetical protein D910_04271 [Dendroctonus ponderosae] -- -- -- -- -- K10660 MARCH5 E3 ubiquitin-protein ligase MARCH5 http://www.genome.jp/dbget-bin/www_bget?ko:K10660 Q6GM44 881 2.4e-93 E3 ubiquitin-protein ligase MARCH5 OS=Xenopus laevis GN=march5 PE=2 SV=1 PF12906//PF00628//PF13639 RING-variant domain//PHD-finger//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.35371 BP_3 35.29 1.40 1504 642922826 XP_008193342.1 972 1.9e-102 PREDICTED: rhodopsin, GQ-coupled isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P43119 167 1.7e-10 Prostacyclin receptor OS=Homo sapiens GN=PTGIR PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.35372 BP_3 65.50 5.27 891 346986300 NP_001231307.1 1481 1.1e-161 polyubiquitin-C [Cricetulus griseus]>gi|2627133|dbj|BAA23488.1| polyubiquitin [Cricetulus griseus] 752889465 XM_011264380.1 380 0 PREDICTED: Camponotus floridanus polyubiquitin-C (LOC105255223), mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 1481 4.4e-163 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF14560//PF00240//PF04452 Ubiquitin-like domain//Ubiquitin family//RNA methyltransferase GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35373 BP_3 64.86 1.93 1909 270013993 EFA10441.1 225 1.0e-15 hypothetical protein TcasGA2_TC012686 [Tribolium castaneum] 642935946 XM_008200020.1 74 6.27491e-28 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35374 BP_3 854.39 9.20 4767 91083171 XP_972171.1 2439 4.7e-272 PREDICTED: mRNA-capping enzyme [Tribolium castaneum]>gi|270006979|gb|EFA03427.1| hypothetical protein TcasGA2_TC013414 [Tribolium castaneum] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 O55236 1662 2.4e-183 mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1 PF01331//PF00102//PF03919//PF15182//PF00782 mRNA capping enzyme, catalytic domain//Protein-tyrosine phosphatase//mRNA capping enzyme, C-terminal domain//Otospiralin//Dual specificity phosphatase, catalytic domain GO:0035335//GO:0006370//GO:0007605//GO:0006470//GO:0006570//GO:0006397 peptidyl-tyrosine dephosphorylation//7-methylguanosine mRNA capping//sensory perception of sound//protein dephosphorylation//tyrosine metabolic process//mRNA processing GO:0004651//GO:0004725//GO:0004484//GO:0008138 polynucleotide 5'-phosphatase activity//protein tyrosine phosphatase activity//mRNA guanylyltransferase activity//protein tyrosine/serine/threonine phosphatase activity GO:0005634 nucleus KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.35375 BP_3 972.69 12.58 4018 270012994 EFA09442.1 3262 0.0e+00 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61824 1131 7.7e-122 Disintegrin and metalloproteinase domain-containing protein 12 OS=Mus musculus GN=Adam12 PE=1 SV=2 PF08516//PF07998//PF01421//PF10462//PF06701//PF00413//PF01562 ADAM cysteine-rich//Peptidase family M54//Reprolysin (M12B) family zinc metalloprotease//Peptidase M66//Mib_herc2//Matrixin//Reprolysin family propeptide GO:0006508//GO:0016567 proteolysis//protein ubiquitination GO:0008270//GO:0004222//GO:0004842//GO:0046872 zinc ion binding//metalloendopeptidase activity//ubiquitin-protein transferase activity//metal ion binding GO:0031012 extracellular matrix KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family Cluster-8309.35376 BP_3 803.28 2.80 14129 189233641 XP_001814986.1 2409 4.2e-268 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 242018850 XM_002429839.1 113 9.85274e-49 Pediculus humanus corporis nicotinate phosphoribosyltransferase, putative, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2054 2.5e-228 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF13465//PF02749//PF08603//PF13912//PF01213//PF02892//PF00096//PF07776 Zinc-finger double domain//Quinolinate phosphoribosyl transferase, N-terminal domain//Adenylate cyclase associated (CAP) C terminal//C2H2-type zinc finger//Adenylate cyclase associated (CAP) N terminal//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0007010 cytoskeleton organization GO:0008270//GO:0016763//GO:0003677//GO:0003779//GO:0046872 zinc ion binding//transferase activity, transferring pentosyl groups//DNA binding//actin binding//metal ion binding GO:0005634 nucleus KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.35377 BP_3 1987.71 56.22 1996 859132836 AKO63327.1 2080 8.4e-231 S-adenosylhomocysteine hydrolase 1 [Leptinotarsa decemlineata] 751460631 XM_011186787.1 280 2.00699e-142 PREDICTED: Bactrocera cucurbitae adenosylhomocysteinase (LOC105213739), mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q27580 1877 1.2e-208 Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=2 SV=2 PF00208//PF05221//PF07992//PF02254//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//S-adenosyl-L-homocysteine hydrolase//Pyridine nucleotide-disulphide oxidoreductase//TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006520//GO:0006555//GO:0055114//GO:0006730//GO:0006813 cellular amino acid metabolic process//methionine metabolic process//oxidation-reduction process//one-carbon metabolic process//potassium ion transport GO:0016491//GO:0004013//GO:0051287 oxidoreductase activity//adenosylhomocysteinase activity//NAD binding -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.35378 BP_3 78.14 0.91 4413 642918838 XP_008191608.1 2788 0.0e+00 PREDICTED: breast carcinoma-amplified sequence 3 homolog isoform X1 [Tribolium castaneum] 642918837 XM_008193386.1 258 7.60049e-130 PREDICTED: Tribolium castaneum breast carcinoma-amplified sequence 3 homolog (LOC661755), transcript variant X1, mRNA -- -- -- -- Q8SY41 1526 1.3e-167 Breast carcinoma-amplified sequence 3 homolog OS=Drosophila melanogaster GN=rudhira PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2109 WD40 repeat protein Cluster-8309.35380 BP_3 297.00 12.36 1450 91081433 XP_973525.1 769 6.3e-79 PREDICTED: zinc finger protein 622 [Tribolium castaneum]>gi|270005162|gb|EFA01610.1| hypothetical protein TcasGA2_TC007176 [Tribolium castaneum] -- -- -- -- -- K14816 REI1 pre-60S factor REI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14816 Q969S3 526 3.9e-52 Zinc finger protein 622 OS=Homo sapiens GN=ZNF622 PE=1 SV=1 PF02892//PF13465//PF00096//PF04988//PF07535 BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//DBF zinc finger -- -- GO:0003676//GO:0003677//GO:0008270//GO:0046872 nucleic acid binding//DNA binding//zinc ion binding//metal ion binding GO:0005622//GO:0005634 intracellular//nucleus KOG2785 C2H2-type Zn-finger protein Cluster-8309.35381 BP_3 26.23 1.23 1320 91086693 XP_969563.1 484 6.5e-46 PREDICTED: 12 kDa FK506-binding protein [Tribolium castaneum]>gi|270010405|gb|EFA06853.1| hypothetical protein TcasGA2_TC009796 [Tribolium castaneum] -- -- -- -- -- K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 P48375 429 6.3e-41 12 kDa FK506-binding protein OS=Drosophila melanogaster GN=FK506-bp2 PE=3 SV=2 PF01581 FMRFamide related peptide family GO:0007218//GO:0006457//GO:0000413 neuropeptide signaling pathway//protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.35382 BP_3 13192.67 1608.64 687 91091510 XP_969238.1 886 8.2e-93 PREDICTED: 60S ribosomal protein L15 [Tribolium castaneum]>gi|642936867|ref|XP_008193026.1| PREDICTED: 60S ribosomal protein L15 [Tribolium castaneum]>gi|270000932|gb|EEZ97379.1| hypothetical protein TcasGA2_TC011204 [Tribolium castaneum] 315115480 HQ424769.1 142 3.45856e-66 Euphydryas aurinia ribosomal protein L15 (RpL15) mRNA, complete cds K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 P30736 776 1.9e-81 60S ribosomal protein L15 OS=Chironomus tentans GN=RpL15 PE=3 SV=3 PF00827 Ribosomal L15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-8309.35383 BP_3 131.19 6.47 1269 91079320 XP_967967.1 669 2.2e-67 PREDICTED: probable DNA-3-methyladenine glycosylase [Tribolium castaneum]>gi|270004337|gb|EFA00785.1| hypothetical protein TcasGA2_TC003671 [Tribolium castaneum] -- -- -- -- -- K03652 MPG DNA-3-methyladenine glycosylase http://www.genome.jp/dbget-bin/www_bget?ko:K03652 Q04841 483 3.3e-47 DNA-3-methyladenine glycosylase OS=Mus musculus GN=Mpg PE=2 SV=3 PF02245 Methylpurine-DNA glycosylase (MPG) GO:0006284 base-excision repair GO:0003677//GO:0003905//GO:0003824 DNA binding//alkylbase DNA N-glycosylase activity//catalytic activity -- -- -- -- Cluster-8309.35384 BP_3 42.00 1.78 1428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35385 BP_3 87.53 0.60 7324 91088689 XP_974981.1 1095 5.1e-116 PREDICTED: protein phosphatase 1 regulatory subunit 7 [Tribolium castaneum] 665810299 XM_008555343.1 133 3.88324e-60 PREDICTED: Microplitis demolitor eukaryotic translation initiation factor 5A (LOC103575518), transcript variant X2, mRNA K17550 PPP1R7, SDS22 protein phosphatase 1 regulatory subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17550 Q5HZV9 759 1.9e-78 Protein phosphatase 1 regulatory subunit 7 OS=Rattus norvegicus GN=Ppp1r7 PE=1 SV=1 PF01287//PF13912//PF00560//PF00651//PF00096//PF13855 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//C2H2-type zinc finger//Leucine Rich Repeat//BTB/POZ domain//Zinc finger, C2H2 type//Leucine rich repeat GO:0045901//GO:0045905//GO:0006448//GO:0006452 positive regulation of translational elongation//positive regulation of translational termination//regulation of translational elongation//translational frameshifting GO:0046872//GO:0003746//GO:0005515//GO:0003723//GO:0043022 metal ion binding//translation elongation factor activity//protein binding//RNA binding//ribosome binding GO:0005840 ribosome KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.35386 BP_3 123.10 4.28 1679 91095049 XP_972102.1 649 6.0e-65 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 339 2.2e-30 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35388 BP_3 842.00 43.49 1225 546674527 ERL85887.1 1201 4.3e-129 hypothetical protein D910_03302 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15122 867 9.6e-92 Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.35389 BP_3 33.47 0.98 1931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02121 Phosphatidylinositol transfer protein GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.35390 BP_3 776.89 2.87 13340 642926407 XP_008191950.1 4357 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.22903e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.8e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF02121//PF00529//PF05920//PF03325//PF03699//PF10541//PF00046//PF02376 Phosphatidylinositol transfer protein//HlyD membrane-fusion protein of T1SS//Homeobox KN domain//Herpesvirus polymerase accessory protein//Uncharacterised protein family (UPF0182)//Nuclear envelope localisation domain//Homeobox domain//CUT domain GO:0006260//GO:0006355//GO:0006810//GO:0055085//GO:0019079 DNA replication//regulation of transcription, DNA-templated//transport//transmembrane transport//viral genome replication GO:0003677//GO:0030337 DNA binding//DNA polymerase processivity factor activity GO:0016020//GO:0005622//GO:0042575//GO:0016021 membrane//intracellular//DNA polymerase complex//integral component of membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.35393 BP_3 10592.20 605.43 1135 674303998 AIL23530.1 1176 3.2e-126 ribosomal protein S3 [Tenebrio molitor] 642920571 XM_008194244.1 336 8.35149e-174 PREDICTED: Tribolium castaneum ribosomal protein S3 (RpS3), transcript variant X1, mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 P02350 1019 2.1e-109 40S ribosomal protein S3-A OS=Xenopus laevis GN=rps3-a PE=2 SV=2 PF07650 KH domain -- -- GO:0003723 RNA binding -- -- KOG3181 40S ribosomal protein S3 Cluster-8309.35394 BP_3 899.00 318.62 427 91080173 XP_970371.1 349 9.4e-31 PREDICTED: cytochrome b-c1 complex subunit 8 [Tribolium castaneum]>gi|270006414|gb|EFA02862.1| ubiquinol-cytochrome c reductase, complex III subunit VII [Tribolium castaneum] -- -- -- -- -- K00418 QCR8, UQCRQ ubiquinol-cytochrome c reductase subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K00418 Q9CQ69 203 3.3e-15 Cytochrome b-c1 complex subunit 8 OS=Mus musculus GN=Uqcrq PE=1 SV=3 PF10890//PF02939 Protein of unknown function (DUF2741)//UcrQ family GO:0006119//GO:0015992//GO:0006118//GO:0022900 oxidative phosphorylation//proton transport//obsolete electron transport//electron transport chain GO:0008121 ubiquinol-cytochrome-c reductase activity GO:0005743//GO:0070469 mitochondrial inner membrane//respiratory chain KOG4116 Ubiquinol cytochrome c reductase, subunit QCR8 Cluster-8309.35395 BP_3 28.41 0.36 4101 546671316 ERL83681.1 930 3.9e-97 hypothetical protein D910_00859 [Dendroctonus ponderosae]>gi|546672389|gb|ERL84277.1| hypothetical protein D910_01664 [Dendroctonus ponderosae] -- -- -- -- -- K08002 MMP24 matrix metalloproteinase-24 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K08002 Q9GLE4 481 1.8e-46 Matrix metalloproteinase-14 OS=Bos taurus GN=MMP14 PE=2 SV=1 PF02691 Vacuolating cyotoxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.35396 BP_3 113.64 2.41 2567 270006955 EFA03403.1 2952 0.0e+00 hypothetical protein TcasGA2_TC013390 [Tribolium castaneum] 347966055 XM_321614.4 107 3.83444e-46 Anopheles gambiae str. PEST AGAP001507-PA (AgaP_AGAP001507) mRNA, complete cds K13647 PLODN procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K13647 Q5U367 1892 2.8e-210 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 OS=Rattus norvegicus GN=Plod3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1971 Lysyl hydroxylase Cluster-8309.35397 BP_3 53.68 1.96 1611 332375941 AEE63111.1 1000 1.2e-105 unknown [Dendroctonus ponderosae]>gi|478258807|gb|ENN78823.1| hypothetical protein YQE_04722, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.35399 BP_3 49.20 0.77 3357 478262788 ENN81305.1 4017 0.0e+00 hypothetical protein YQE_02273, partial [Dendroctonus ponderosae]>gi|546672906|gb|ERL84622.1| hypothetical protein D910_02050 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2V2M9 1472 1.8e-161 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF01059//PF06371 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Diaphanous GTPase-binding Domain GO:0030036//GO:0055114//GO:0006120 actin cytoskeleton organization//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.354 BP_3 23.11 1.77 920 642914430 XP_008201676.1 580 3.3e-57 PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum]>gi|642914432|ref|XP_008201677.1| PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XZC8 446 4.7e-43 Semaphorin-2A OS=Schistocerca gregaria GN=SEMA-2A PE=2 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35401 BP_3 733.11 40.19 1171 642913599 XP_008201080.1 450 5.0e-42 PREDICTED: extensin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05109//PF03153 Herpes virus major outer envelope glycoprotein (BLLF1)//Transcription factor IIA, alpha/beta subunit GO:0006367//GO:0019058 transcription initiation from RNA polymerase II promoter//viral life cycle -- -- GO:0005672//GO:0019031 transcription factor TFIIA complex//viral envelope -- -- Cluster-8309.35402 BP_3 47.50 0.41 5812 699049757 AIU39233.1 742 3.4e-75 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 532 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 691 1.2e-70 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF00769//PF11365//PF15898//PF03577//PF06160//PF10473//PF05739//PF10186//PF08702//PF04513//PF02601//PF07926//PF16326//PF07851//PF06009//PF14073 Ezrin/radixin/moesin family//Protein of unknown function (DUF3166)//cGMP-dependent protein kinase interacting domain//Peptidase family C69//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Vacuolar sorting 38 and autophagy-related subunit 14//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//TPR/MLP1/MLP2-like protein//ABC transporter C-terminal domain//TMPIT-like protein//Laminin Domain II//Centrosome localisation domain of Cep57 GO:0006308//GO:0007155//GO:0010508//GO:0051258//GO:0007165//GO:0030168//GO:0006508//GO:0000921//GO:0006606//GO:0010506 DNA catabolic process//cell adhesion//positive regulation of autophagy//protein polymerization//signal transduction//platelet activation//proteolysis//septin ring assembly//protein import into nucleus//regulation of autophagy GO:0042803//GO:0043015//GO:0008855//GO:0005515//GO:0042802//GO:0003677//GO:0016805//GO:0019901//GO:0005198//GO:0030674//GO:0008092//GO:0005102//GO:0045502//GO:0008134 protein homodimerization activity//gamma-tubulin binding//exodeoxyribonuclease VII activity//protein binding//identical protein binding//DNA binding//dipeptidase activity//protein kinase binding//structural molecule activity//protein binding, bridging//cytoskeletal protein binding//receptor binding//dynein binding//transcription factor binding GO:0019031//GO:0005737//GO:0005940//GO:0016021//GO:0005667//GO:0030286//GO:0005615//GO:0005577//GO:0009318//GO:0045298//GO:0019898//GO:0019028 viral envelope//cytoplasm//septin ring//integral component of membrane//transcription factor complex//dynein complex//extracellular space//fibrinogen complex//exodeoxyribonuclease VII complex//tubulin complex//extrinsic component of membrane//viral capsid KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.35403 BP_3 878.02 12.26 3744 642921818 XP_008199331.1 2491 3.5e-278 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] 665798678 XM_008549002.1 56 1.25888e-17 PREDICTED: Microplitis demolitor vitamin K-dependent gamma-carboxylase (LOC103571031), transcript variant X3, mRNA K10106 GGCX vitamin K-dependent gamma-carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10106 Q9MYY3 1371 1.1e-149 Vitamin K-dependent gamma-carboxylase OS=Delphinapterus leucas GN=GGCX PE=2 SV=1 PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.35404 BP_3 320.18 15.63 1279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35405 BP_3 907.46 12.87 3689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35406 BP_3 738.79 6.87 5474 270001371 EEZ97818.1 1191 2.8e-127 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914990 XM_008192251.1 500 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X3, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 Q7TMK9 769 9.9e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 PF11411//PF16367//PF00076//PF07648//PF00023 DNA ligase IV//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Kazal-type serine protease inhibitor domain//Ankyrin repeat GO:0006281//GO:0006260 DNA repair//DNA replication GO:0005515//GO:0003910//GO:0003676 protein binding//DNA ligase (ATP) activity//nucleic acid binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.35407 BP_3 325.00 46.86 626 820805544 AKG92763.1 240 6.0e-18 max [Leptinotarsa decemlineata] 642929578 XM_970277.2 94 1.51132e-39 PREDICTED: Tribolium castaneum protein max (LOC664267), transcript variant X3, mRNA K04453 MAX Max protein http://www.genome.jp/dbget-bin/www_bget?ko:K04453 P28574 159 6.1e-10 Protein max OS=Mus musculus GN=Max PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG2483 Upstream transcription factor 2/L-myc-2 protein Cluster-8309.35408 BP_3 523.85 6.66 4081 642930308 XP_008196340.1 966 2.6e-101 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 1.2e-34 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF03325//PF00439 Herpesvirus polymerase accessory protein//Bromodomain GO:0006260//GO:0019079 DNA replication//viral genome replication GO:0030337//GO:0005515 DNA polymerase processivity factor activity//protein binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.35409 BP_3 19.00 3.41 560 546677638 ERL88439.1 198 4.0e-13 hypothetical protein D910_05825 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02024//PF05791 Leptin//Bacillus haemolytic enterotoxin (HBL) GO:0007165//GO:0009405 signal transduction//pathogenesis GO:0005179 hormone activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.35410 BP_3 29.64 1.84 1070 91083227 XP_973632.1 491 8.1e-47 PREDICTED: 40S ribosomal protein S18 [Tribolium castaneum]>gi|270007711|gb|EFA04159.1| hypothetical protein TcasGA2_TC014405 [Tribolium castaneum] 264667372 GU120422.1 146 3.2791e-68 Chrysomela tremulae ribosomal protein S18 (RpS18) mRNA, complete cds K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q962R1 478 1.1e-46 40S ribosomal protein S18 OS=Spodoptera frugiperda GN=RpS18 PE=2 SV=1 PF00416 Ribosomal protein S13/S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3311 Ribosomal protein S18 Cluster-8309.35411 BP_3 57.23 1.73 1888 727098862 AIY54293.1 1827 1.7e-201 actin 1 [Colaphellus bowringi] 805784743 XM_003703098.2 249 3.24152e-125 PREDICTED: Megachile rotundata actin-related protein 3 (LOC100883662), mRNA K18584 ACTR3, ARP3 actin-related protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18584 P32392 1701 2.9e-188 Actin-related protein 3 OS=Drosophila melanogaster GN=Arp3 PE=2 SV=3 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0678 Actin-related protein Arp2/3 complex, subunit Arp3 Cluster-8309.35412 BP_3 18.83 0.58 1850 189240443 XP_972854.2 348 5.3e-30 PREDICTED: lysosomal-associated transmembrane protein 4B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35413 BP_3 2889.43 75.56 2135 189240443 XP_972854.2 1224 1.6e-131 PREDICTED: lysosomal-associated transmembrane protein 4B [Tribolium castaneum] -- -- -- -- -- K12387 LAPTM lysosomal-associated transmembrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K12387 Q71SV0 285 5.1e-24 Lysosomal-associated transmembrane protein 4B OS=Bos taurus GN=LAPTM4B PE=2 SV=1 PF14991//PF03821 Protein melan-A//Golgi 4-transmembrane spanning transporter -- -- -- -- GO:0016021//GO:0042470 integral component of membrane//melanosome -- -- Cluster-8309.35414 BP_3 37.84 0.59 3360 270005671 EFA02119.1 2743 1.9e-307 hypothetical protein TcasGA2_TC007765 [Tribolium castaneum] 658920433 XM_008401725.1 75 3.09361e-28 PREDICTED: Poecilia reticulata transportin 3 (tnpo3), mRNA K15436 TRPO3, MTR10 transportin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K15436 Q6P2B1 1483 9.8e-163 Transportin-3 OS=Mus musculus GN=Tnpo3 PE=1 SV=1 PF03810//PF05823 Importin-beta N-terminal domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1) GO:0006886 intracellular protein transport GO:0008289//GO:0008536 lipid binding//Ran GTPase binding -- -- KOG2081 Nuclear transport regulator Cluster-8309.35415 BP_3 1402.75 63.77 1352 270002990 EEZ99437.1 667 4.0e-67 hypothetical protein TcasGA2_TC030635 [Tribolium castaneum] -- -- -- -- -- K18646 ANP32A_C_D acidic leucine-rich nuclear phosphoprotein 32 family member A/C/D http://www.genome.jp/dbget-bin/www_bget?ko:K18646 Q28XE2 547 1.3e-54 Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Drosophila pseudoobscura pseudoobscura GN=Anp32a PE=3 SV=2 PF13855//PF13516 Leucine rich repeat//Leucine Rich repeat -- -- GO:0005515 protein binding -- -- KOG2739 Leucine-rich acidic nuclear protein Cluster-8309.35416 BP_3 10531.73 1630.55 603 264667375 ACY71273.1 745 1.6e-76 ribosomal protein S16 [Chrysomela tremula] 195123788 XM_002006349.1 138 5.04292e-64 Drosophila mojavensis GI21016 (Dmoj\GI21016), mRNA K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 P62251 661 3.6e-68 40S ribosomal protein S16 OS=Aedes aegypti GN=RpS16 PE=2 SV=1 PF00380 Ribosomal protein S9/S16 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-8309.35417 BP_3 11508.37 470.37 1471 674656865 AIL26079.1 768 8.4e-79 ferritin 2 [Monochamus alternatus] 674656864 KJ872588.1 138 1.2723e-63 Monochamus alternatus ferritin 2 mRNA, complete cds -- -- -- -- P41822 127 7.4e-06 Ferritin subunit OS=Aedes aegypti GN=FERH PE=1 SV=2 PF00210 Ferritin-like domain GO:0006879 cellular iron ion homeostasis GO:0008199 ferric iron binding -- -- -- -- Cluster-8309.35419 BP_3 1275.85 57.03 1370 91079744 XP_970506.1 1421 1.5e-154 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 768418014 XM_011551373.1 210 1.11773e-103 PREDICTED: Plutella xylostella probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial (LOC105381602), transcript variant X4, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 1246 1.2e-135 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF00441//PF02770//PF02771 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0008152//GO:0006118 oxidation-reduction process//metabolic process//obsolete electron transport GO:0016627//GO:0003995//GO:0050660 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.35420 BP_3 6108.39 76.59 4136 194766015 XP_001965120.1 311 2.3e-25 GF23497 [Drosophila ananassae]>gi|190617730|gb|EDV33254.1| GF23497 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35421 BP_3 4080.29 20.69 9796 478255507 ENN75724.1 1979 2.1e-218 hypothetical protein YQE_07684, partial [Dendroctonus ponderosae] -- -- -- -- -- K17800 LETM1, MDM38 LETM1 and EF-hand domain-containing protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17800 P91927 1023 6.2e-109 LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrial OS=Drosophila melanogaster GN=Letm1 PE=2 SV=2 PF13499 EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG1043 Ca2+-binding transmembrane protein LETM1/MRS7 Cluster-8309.35423 BP_3 146.00 13.93 797 332375993 AEE63137.1 801 6.8e-83 unknown [Dendroctonus ponderosae]>gi|478258109|gb|ENN78247.1| hypothetical protein YQE_05398, partial [Dendroctonus ponderosae]>gi|546682789|gb|ERL92678.1| hypothetical protein D910_09990 [Dendroctonus ponderosae] -- -- -- -- -- K02871 RP-L13, MRPL13, rplM large subunit ribosomal protein L13 http://www.genome.jp/dbget-bin/www_bget?ko:K02871 Q9VJ38 693 9.3e-72 39S ribosomal protein L13, mitochondrial OS=Drosophila melanogaster GN=mRpL13 PE=2 SV=2 PF00572 Ribosomal protein L13 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3203 Mitochondrial/chloroplast ribosomal protein L13 Cluster-8309.35424 BP_3 64.14 0.73 4544 642910567 XP_008200269.1 2106 1.8e-233 PREDICTED: patj homolog [Tribolium castaneum] -- -- -- -- -- K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 Q9NB04 1007 2.1e-107 Patj homolog OS=Drosophila melanogaster GN=Patj PE=1 SV=2 PF05965//PF13180//PF00595 F/Y rich C-terminus//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding GO:0005634 nucleus KOG3528 FOG: PDZ domain Cluster-8309.35426 BP_3 20116.19 135.56 7444 642920903 XP_008192608.1 9659 0.0e+00 PREDICTED: spectrin beta chain isoform X2 [Tribolium castaneum] 642920904 XM_008194387.1 1976 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X5, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7569 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00435//PF00307 Spectrin repeat//Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.35428 BP_3 11230.53 1477.78 658 805784468 XP_003703131.2 919 1.2e-96 PREDICTED: 60S ribosomal protein L9 [Megachile rotundata] 264667320 GU120396.1 237 5.11632e-119 Chrysomela tremulae ribosomal protein L9 (RpL9) mRNA, complete cds K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 Q963B7 849 6.3e-90 60S ribosomal protein L9 OS=Spodoptera frugiperda GN=RpL9 PE=2 SV=1 PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-8309.35430 BP_3 1262.29 10.29 6205 642935181 XP_008199681.1 2449 4.2e-273 PREDICTED: uncharacterized protein LOC655640 [Tribolium castaneum]>gi|642935183|ref|XP_008199682.1| PREDICTED: uncharacterized protein LOC655640 [Tribolium castaneum]>gi|642935185|ref|XP_008199683.1| PREDICTED: uncharacterized protein LOC655640 [Tribolium castaneum] 642935184 XM_008201461.1 395 0 PREDICTED: Tribolium castaneum uncharacterized LOC655640 (LOC655640), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35433 BP_3 1672.06 98.61 1109 642919985 XP_975111.2 901 2.4e-94 PREDICTED: 7-methylguanosine phosphate-specific 5'-nucleotidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q9W197 645 4.8e-66 7-methylguanosine phosphate-specific 5'-nucleotidase OS=Drosophila melanogaster GN=CG3362 PE=1 SV=1 PF05822 Pyrimidine 5'-nucleotidase (UMPH-1) -- -- GO:0008253//GO:0000287 5'-nucleotidase activity//magnesium ion binding GO:0005737 cytoplasm KOG3128 Uncharacterized conserved protein Cluster-8309.35434 BP_3 4.48 0.65 623 91091798 XP_970498.1 395 6.4e-36 PREDICTED: 40S ribosomal protein S14 [Tribolium castaneum]>gi|642937302|ref|XP_008198777.1| PREDICTED: 40S ribosomal protein S14 [Tribolium castaneum]>gi|270000834|gb|EEZ97281.1| hypothetical protein TcasGA2_TC011085 [Tribolium castaneum] 620695572 KJ489363.1 138 5.22018e-64 Dastarcus helophoroides ribosomal protein mRNA, complete cds K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 Q6XI08 376 4.2e-35 40S ribosomal protein S14a OS=Drosophila yakuba GN=RpS14a PE=2 SV=1 PF00411 Ribosomal protein S11 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-8309.35435 BP_3 592.00 14.01 2328 270014974 EFA11422.1 534 1.8e-51 hypothetical protein TcasGA2_TC013599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35436 BP_3 1113.89 47.33 1426 91080861 XP_971851.1 1327 1.2e-143 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [Tribolium castaneum]>gi|270006430|gb|EFA02878.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 [Tribolium castaneum] -- -- -- -- -- K03954 NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03954 P91929 984 3.0e-105 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Drosophila melanogaster GN=ND42 PE=2 SV=2 PF03796//PF02367//PF02224 DnaB-like helicase C terminal domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Cytidylate kinase GO:0006139//GO:0002949//GO:0006260//GO:0006206 nucleobase-containing compound metabolic process//tRNA threonylcarbamoyladenosine modification//DNA replication//pyrimidine nucleobase metabolic process GO:0005524//GO:0003678//GO:0004127 ATP binding//DNA helicase activity//cytidylate kinase activity GO:0005657 replication fork KOG3877 NADH:ubiquinone oxidoreductase, NDUFA10/42kDa subunit Cluster-8309.35438 BP_3 245.85 7.72 1827 642915291 XP_008190557.1 1283 2.0e-138 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 602 7.6e-61 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.35439 BP_3 835.20 12.15 3604 817053577 XP_012262754.1 1796 1.3e-197 PREDICTED: nucleolar protein 58 [Athalia rosae] 242020751 XM_002430770.1 269 4.7558e-136 Pediculus humanus corporis Nucleolar protein NOP5, putative, mRNA K14565 NOP58 nucleolar protein 58 http://www.genome.jp/dbget-bin/www_bget?ko:K14565 Q9Y2X3 1418 3.6e-155 Nucleolar protein 58 OS=Homo sapiens GN=NOP58 PE=1 SV=1 PF04858//PF08769//PF11802 TH1 protein//Sporulation initiation factor Spo0A C terminal//Centromere-associated protein K GO:0006355//GO:0045892//GO:0042173 regulation of transcription, DNA-templated//negative regulation of transcription, DNA-templated//regulation of sporulation resulting in formation of a cellular spore GO:0005509//GO:0003700 calcium ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005737 nucleus//transcription factor complex//cytoplasm KOG2572 Ribosome biogenesis protein - Nop58p/Nop5p Cluster-8309.35440 BP_3 120.00 7.16 1100 91078898 XP_973390.1 1001 6.0e-106 PREDICTED: negative elongation factor D [Tribolium castaneum]>gi|270004155|gb|EFA00603.1| hypothetical protein TcasGA2_TC003474 [Tribolium castaneum] -- -- -- -- -- K15181 TH1L, NELFD negative elongation factor C/D http://www.genome.jp/dbget-bin/www_bget?ko:K15181 Q24134 801 3.9e-84 Negative elongation factor D OS=Drosophila melanogaster GN=TH1 PE=1 SV=2 PF04858 TH1 protein GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.35442 BP_3 233.70 3.00 4041 91082905 XP_972330.1 2058 6.0e-228 PREDICTED: eukaryotic translation initiation factor 2A [Tribolium castaneum]>gi|270007067|gb|EFA03515.1| hypothetical protein TcasGA2_TC013517 [Tribolium castaneum] -- -- -- -- -- K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K08745 Q60714 1252 7.2e-136 Long-chain fatty acid transport protein 1 OS=Mus musculus GN=Slc27a1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.35443 BP_3 31.82 0.71 2463 91091790 XP_970226.1 2316 4.5e-258 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X1 [Tribolium castaneum] 195481875 XM_002101781.1 65 8.18764e-23 Drosophila yakuba GE15405 (Dyak\GE15405), partial mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 1574 2.0e-173 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.35446 BP_3 21.03 1.67 898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83653 208 1.8e-15 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.35447 BP_3 24.79 0.54 2488 646709417 KDR15281.1 708 1.3e-71 Peptidyl-prolyl cis-trans isomerase [Zootermopsis nevadensis] 755876427 XM_005183940.2 153 9.96959e-72 PREDICTED: Musca domestica peptidyl-prolyl cis-trans isomerase (LOC101898665), mRNA K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 P54985 683 4.2e-70 Peptidyl-prolyl cis-trans isomerase OS=Blattella germanica GN=CYPA PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.35448 BP_3 845.00 70.19 872 91087761 XP_974991.1 1012 2.5e-107 PREDICTED: proteasome subunit beta type-4 [Tribolium castaneum]>gi|270009385|gb|EFA05833.1| hypothetical protein TcasGA2_TC008617 [Tribolium castaneum] -- -- -- -- -- K02736 PSMB4 20S proteasome subunit beta 7 http://www.genome.jp/dbget-bin/www_bget?ko:K02736 P99026 683 1.5e-70 Proteasome subunit beta type-4 OS=Mus musculus GN=Psmb4 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005737//GO:0005634//GO:0005839 cytoplasm//nucleus//proteasome core complex KOG0185 20S proteasome, regulatory subunit beta type PSMB4/PRE4 Cluster-8309.35450 BP_3 16.00 15.41 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35455 BP_3 10.87 0.52 1303 546674022 ERL85515.1 440 8.0e-41 hypothetical protein D910_02934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15330 182 2.7e-12 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35459 BP_3 95.62 1.97 2637 817086172 XP_012265802.1 1842 4.4e-203 PREDICTED: stress-induced-phosphoprotein 1 isoform X2 [Athalia rosae] 831315386 XM_012834849.1 54 1.1431e-16 PREDICTED: Clupea harengus stress-induced phosphoprotein 1 (stip1), mRNA K09553 STIP1 stress-induced-phosphoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09553 Q4R8N7 1433 4.8e-157 Stress-induced-phosphoprotein 1 OS=Macaca fascicularis GN=STIP1 PE=2 SV=1 PF13181//PF02064//PF13174//PF00515//PF13374//PF13371//PF09392//PF13414//PF13176 Tetratricopeptide repeat//MAS20 protein import receptor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//TPR repeat//Tetratricopeptide repeat GO:0006605//GO:0009405//GO:0015031//GO:0006886 protein targeting//pathogenesis//protein transport//intracellular protein transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG0548 Molecular co-chaperone STI1 Cluster-8309.35460 BP_3 427.00 14.07 1754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01912 eIF-6 family GO:0042256 mature ribosome assembly GO:0043022 ribosome binding -- -- -- -- Cluster-8309.35462 BP_3 414.67 14.23 1696 478257813 ENN77956.1 1791 2.3e-197 hypothetical protein YQE_05633, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 325 9.3e-29 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35463 BP_3 555.88 12.93 2364 642930224 XP_008196307.1 2219 7.6e-247 PREDICTED: probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [Tribolium castaneum] 543271752 XM_005425019.1 98 3.55206e-41 PREDICTED: Geospiza fortis methylcrotonoyl-CoA carboxylase beta chain, mitochondrial-like (LOC102043970), mRNA K01969 E6.4.1.4B 3-methylcrotonyl-CoA carboxylase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01969 Q9V9A7 1913 9.4e-213 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Drosophila melanogaster GN=l(2)04524 PE=2 SV=1 PF10186//PF00484//PF06833 Vacuolar sorting 38 and autophagy-related subunit 14//Carbonic anhydrase//Malonate decarboxylase gamma subunit (MdcE) GO:0006730//GO:0006807//GO:0010508 one-carbon metabolic process//nitrogen compound metabolic process//positive regulation of autophagy GO:0008270//GO:0004089//GO:0016874 zinc ion binding//carbonate dehydratase activity//ligase activity -- -- KOG0540 3-Methylcrotonyl-CoA carboxylase, non-biotin containing subunit/Acetyl-CoA carboxylase carboxyl transferase, subunit beta Cluster-8309.35465 BP_3 2087.03 63.54 1875 642931046 XP_008196190.1 741 1.5e-75 PREDICTED: myeloid leukemia factor isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NKV0 353 5.8e-32 Myeloid leukemia factor OS=Drosophila melanogaster GN=Mlf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35469 BP_3 2238.20 88.41 1512 91085705 XP_972760.1 563 5.1e-55 PREDICTED: UBX domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5HZY0 325 8.3e-29 UBX domain-containing protein 4 OS=Rattus norvegicus GN=Ubxn4 PE=2 SV=1 PF05279//PF00789//PF05602 Aspartyl beta-hydroxylase N-terminal region//UBX domain//Cleft lip and palate transmembrane protein 1 (CLPTM1) -- -- GO:0005515 protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains Cluster-8309.35470 BP_3 1294.82 41.19 1807 91090714 XP_975034.1 834 2.3e-86 PREDICTED: 27 kDa hemolymph protein [Tribolium castaneum]>gi|270013294|gb|EFA09742.1| hypothetical protein TcasGA2_TC011877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 378 7.1e-35 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 PF03688 Nepovirus coat protein, C-terminal domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.35471 BP_3 695.47 6.92 5134 91077054 XP_966585.1 1457 3.8e-158 PREDICTED: probable transaldolase [Tribolium castaneum]>gi|270001740|gb|EEZ98187.1| hypothetical protein TcasGA2_TC000616 [Tribolium castaneum] 746851965 XM_011058220.1 116 7.66355e-51 PREDICTED: Acromyrmex echinatior probable transaldolase (LOC105147307), mRNA K00616 E2.2.1.2, talA, talB transaldolase http://www.genome.jp/dbget-bin/www_bget?ko:K00616 Q9EQS0 1175 7.7e-127 Transaldolase OS=Rattus norvegicus GN=Taldo1 PE=1 SV=2 PF02428//PF00923//PF15966//PF00646//PF12937//PF13855 Potato type II proteinase inhibitor family//Transaldolase//F-box//F-box domain//F-box-like//Leucine rich repeat GO:0006098//GO:0005975 pentose-phosphate shunt//carbohydrate metabolic process GO:0005515//GO:0004801//GO:0004867 protein binding//sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity//serine-type endopeptidase inhibitor activity GO:0005737 cytoplasm KOG2772 Transaldolase Cluster-8309.35472 BP_3 1627.84 22.69 3749 642910505 XP_008200243.1 2511 1.7e-280 PREDICTED: SEC23-interacting protein isoform X2 [Tribolium castaneum] 826487484 XM_012683938.1 80 5.74175e-31 PREDICTED: Monomorium pharaonis SEC23-interacting protein-like (LOC105838396), transcript variant X4, mRNA -- -- -- -- Q9Y6Y8 919 2.7e-97 SEC23-interacting protein OS=Homo sapiens GN=SEC23IP PE=1 SV=1 PF02862//PF13724//PF10425 DDHD domain//DNA-binding domain//C-terminus of bacterial fibrinogen-binding adhesin GO:0007155 cell adhesion GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005618 cell wall KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.35474 BP_3 2949.00 36.70 4165 189239123 XP_970925.2 1754 1.1e-192 PREDICTED: protein bicaudal D [Tribolium castaneum]>gi|270011010|gb|EFA07458.1| bicaudal D [Tribolium castaneum] 268536819 XM_002633499.1 38 1.42179e-07 Caenorhabditis briggsae Hypothetical protein CBG05413 (CBG05413) mRNA, complete cds K18739 BICD protein bicaudal D http://www.genome.jp/dbget-bin/www_bget?ko:K18739 P16568 1092 2.6e-117 Protein bicaudal D OS=Drosophila melanogaster GN=BicD PE=1 SV=2 PF08702//PF02183//PF10473//PF10018//PF01544//PF10186//PF09730//PF09510//PF04111//PF06156//PF04632 Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Vitamin-D-receptor interacting Mediator subunit 4//CorA-like Mg2+ transporter protein//Vacuolar sorting 38 and autophagy-related subunit 14//Microtubule-associated protein Bicaudal-D//Rtt102p-like transcription regulator protein//Autophagy protein Apg6//Protein of unknown function (DUF972)//Fusaric acid resistance protein family GO:0010508//GO:0006355//GO:0006357//GO:0006260//GO:0006914//GO:0051258//GO:0006338//GO:0006810//GO:0007165//GO:0055085//GO:0030168//GO:0030001 positive regulation of autophagy//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//DNA replication//autophagy//protein polymerization//chromatin remodeling//transport//signal transduction//transmembrane transport//platelet activation//metal ion transport GO:0003700//GO:0043565//GO:0005102//GO:0045502//GO:0008134//GO:0042803//GO:0030674//GO:0046873//GO:0001104 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//receptor binding//dynein binding//transcription factor binding//protein homodimerization activity//protein binding, bridging//metal ion transmembrane transporter activity//RNA polymerase II transcription cofactor activity GO:0005577//GO:0005794//GO:0016586//GO:0016514//GO:0016020//GO:0005667//GO:0016592//GO:0005634//GO:0005886//GO:0030286 fibrinogen complex//Golgi apparatus//RSC complex//SWI/SNF complex//membrane//transcription factor complex//mediator complex//nucleus//plasma membrane//dynein complex KOG0999 Microtubule-associated protein Bicaudal-D Cluster-8309.35475 BP_3 14.00 0.73 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35476 BP_3 70.65 0.80 4526 642918282 XP_008191443.1 3855 0.0e+00 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X2 [Tribolium castaneum] 195430887 XM_002063444.1 411 0 Drosophila willistoni GK21381 (Dwil\GK21381), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 3178 0.0e+00 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 PF13174//PF05009//PF13181//PF13414//PF13176//PF13374//PF00515//PF02259//PF13371 Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat GO:0016032 viral process GO:0005515 protein binding GO:0042025 host cell nucleus KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.35479 BP_3 173.00 6.34 1607 332372740 AEE61512.1 592 2.4e-58 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7PWV1 213 8.6e-16 Aquaporin AQPAn.G OS=Anopheles gambiae GN=AGAP008842 PE=3 SV=4 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.3548 BP_3 3.00 0.46 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35480 BP_3 7.72 1.81 497 332375004 AEE62643.1 220 9.9e-16 unknown [Dendroctonus ponderosae]>gi|478258425|gb|ENN78519.1| hypothetical protein YQE_05012, partial [Dendroctonus ponderosae]>gi|546676434|gb|ERL87445.1| hypothetical protein D910_04837 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02936 Cytochrome c oxidase subunit IV GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.35484 BP_3 918.97 22.61 2251 478256393 ENN76583.1 2095 1.7e-232 hypothetical protein YQE_07032, partial [Dendroctonus ponderosae]>gi|546680826|gb|ERL91032.1| hypothetical protein D910_08374 [Dendroctonus ponderosae] 167515085 EU267006.1 35 3.5513e-06 Aedes aegypti sodium-dependent nutrient amino acid transporter 8 (NAT8) mRNA, complete cds K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 Q29GB8 1429 1.2e-156 Sodium-dependent nutrient amino acid transporter 1 OS=Drosophila pseudoobscura pseudoobscura GN=NAAT1 PE=3 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.35487 BP_3 1344.33 23.79 3015 189239379 XP_971918.2 690 1.9e-69 PREDICTED: receptor expression-enhancing protein 5 [Tribolium castaneum]>gi|270009667|gb|EFA06115.1| hypothetical protein TcasGA2_TC008958 [Tribolium castaneum] 667676433 AE013599.5 78 5.95915e-30 Drosophila melanogaster chromosome 2R K17279 REEP5_6 receptor expression-enhancing protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K17279 Q29RM3 475 6.7e-46 Receptor expression-enhancing protein 5 OS=Bos taurus GN=REEP5 PE=2 SV=1 PF00886 Ribosomal protein S16 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.3549 BP_3 35.46 1.10 1847 642912712 XP_008200971.1 1144 2.7e-122 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642912714|ref|XP_008200972.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q9WVC8 558 9.8e-56 Chloride anion exchanger OS=Mus musculus GN=Slc26a3 PE=1 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.35491 BP_3 515.88 15.64 1882 642919171 XP_967331.2 1405 1.5e-152 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q810J8 991 6.1e-106 Zinc finger FYVE domain-containing protein 1 OS=Mus musculus GN=Zfyve1 PE=2 SV=2 PF01926//PF02263//PF04548 50S ribosome-binding GTPase//Guanylate-binding protein, N-terminal domain//AIG1 family -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- -- -- Cluster-8309.35492 BP_3 727.00 21.51 1921 332376593 AEE63436.1 947 1.9e-99 unknown [Dendroctonus ponderosae]>gi|478257059|gb|ENN77222.1| hypothetical protein YQE_06052, partial [Dendroctonus ponderosae] -- -- -- -- -- K14713 SLC39A7, KE4, ZIP7 solute carrier family 39 (zinc transporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14713 Q9V3A4 738 1.4e-76 Protein catecholamines up OS=Drosophila melanogaster GN=Catsup PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.35493 BP_3 115597.48 1708.44 3553 546683948 ERL93688.1 203 6.7e-13 hypothetical protein D910_10975 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35495 BP_3 222.24 5.29 2318 478255733 ENN75942.1 1799 3.7e-198 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 810 7.4e-85 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 PF08119//PF00097 Scorpion acidic alpha-KTx toxin family//Zinc finger, C3HC4 type (RING finger) GO:0009405//GO:0006810 pathogenesis//transport GO:0046872//GO:0019870 metal ion binding//potassium channel inhibitor activity GO:0005576 extracellular region KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.35498 BP_3 1165.97 34.32 1929 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35501 BP_3 1082.38 21.07 2768 642927261 XP_008195198.1 1294 1.6e-139 PREDICTED: GDP-fucose protein O-fucosyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K03691 POFUT peptide-O-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03691 Q9W589 731 1.3e-75 GDP-fucose protein O-fucosyltransferase 2 OS=Drosophila melanogaster GN=O-fut2 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0175 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 Cluster-8309.35502 BP_3 24.50 0.31 4073 642923778 XP_008193880.1 997 6.5e-105 PREDICTED: zinc finger protein 395 isoform X1 [Tribolium castaneum] 462336375 APGK01037911.1 36 1.79822e-06 Dendroctonus ponderosae Seq01037921, whole genome shotgun sequence -- -- -- -- Q6DFC8 154 1.5e-08 Zinc finger protein 395 OS=Xenopus laevis GN=znf395 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35503 BP_3 21.49 0.50 2372 478263485 ENN81840.1 578 1.5e-56 hypothetical protein YQE_01779, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35504 BP_3 2.00 0.39 537 478259961 ENN79763.1 604 3.2e-60 hypothetical protein YQE_03819, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35505 BP_3 1607.28 85.01 1203 749731807 XP_011136864.1 1293 9.1e-140 PREDICTED: eukaryotic translation initiation factor 2 subunit 1 [Harpegnathos saltator]>gi|749731809|ref|XP_011136872.1| PREDICTED: eukaryotic translation initiation factor 2 subunit 1 [Harpegnathos saltator] 820840867 XM_003691501.2 401 0 PREDICTED: Apis florea eukaryotic translation initiation factor 2 subunit 1 (LOC100870691), mRNA K03237 EIF2S1 translation initiation factor 2 subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03237 P41374 1060 3.9e-114 Eukaryotic translation initiation factor 2 subunit 1 OS=Drosophila melanogaster GN=eIF-2alpha PE=2 SV=1 PF00575//PF07541 S1 RNA binding domain//Eukaryotic translation initiation factor 2 alpha subunit GO:0006446 regulation of translational initiation GO:0003723//GO:0003743//GO:0003676 RNA binding//translation initiation factor activity//nucleic acid binding GO:0005850//GO:0005840 eukaryotic translation initiation factor 2 complex//ribosome KOG2916 Translation initiation factor 2, alpha subunit (eIF-2alpha) Cluster-8309.35506 BP_3 28.21 0.53 2862 642911817 XP_008200757.1 2573 8.2e-288 PREDICTED: histone-arginine methyltransferase CARMER isoform X1 [Tribolium castaneum]>gi|270014548|gb|EFA10996.1| hypothetical protein TcasGA2_TC004581 [Tribolium castaneum] -- -- -- -- -- K05931 CARM1, PRMT4 histone-arginine methyltransferase CARM1 http://www.genome.jp/dbget-bin/www_bget?ko:K05931 Q174R2 1725 7.2e-191 Histone-arginine methyltransferase CARMER OS=Aedes aegypti GN=CARM1 PE=3 SV=1 PF00443//PF05175//PF08241//PF05185//PF01465//PF03602//PF15127//PF03153 Ubiquitin carboxyl-terminal hydrolase//Methyltransferase small domain//Methyltransferase domain//PRMT5 arginine-N-methyltransferase//GRIP domain//Conserved hypothetical protein 95//Small membrane A-kinase anchor protein//Transcription factor IIA, alpha/beta subunit GO:0031167//GO:0008152//GO:0006367//GO:0016579//GO:0000042//GO:0006479 rRNA methylation//metabolic process//transcription initiation from RNA polymerase II promoter//protein deubiquitination//protein targeting to Golgi//protein methylation GO:0034237//GO:0005515//GO:0036459//GO:0008168 protein kinase A regulatory subunit binding//protein binding//ubiquitinyl hydrolase activity//methyltransferase activity GO:0005672 transcription factor TFIIA complex KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.35509 BP_3 1726.95 10.55 8184 270015918 EFA12366.1 1004 2.0e-105 hypothetical protein TcasGA2_TC002072 [Tribolium castaneum] 642938736 XM_008201646.1 149 5.53723e-69 PREDICTED: Tribolium castaneum RNA polymerase II elongation factor ELL (LOC655479), mRNA K15183 ELL RNA polymerase II elongation factor ELL http://www.genome.jp/dbget-bin/www_bget?ko:K15183 P55199 278 1.3e-22 RNA polymerase II elongation factor ELL OS=Homo sapiens GN=ELL PE=1 SV=1 PF10390//PF05732 RNA polymerase II elongation factor ELL//Firmicute plasmid replication protein (RepL) GO:0006368//GO:0006260//GO:0006276 transcription elongation from RNA polymerase II promoter//DNA replication//plasmid maintenance -- -- GO:0008023 transcription elongation factor complex -- -- Cluster-8309.35510 BP_3 32.20 2.69 868 642937779 XP_008198942.1 503 2.7e-48 PREDICTED: 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [Tribolium castaneum] 642937780 XM_970985.3 85 2.14424e-34 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 4 (LOC658092), transcript variant X2, mRNA K03029 PSMD4, RPN10 26S proteasome regulatory subunit N10 http://www.genome.jp/dbget-bin/www_bget?ko:K03029 Q58DA0 262 9.6e-22 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus GN=PSMD4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35511 BP_3 329.35 10.80 1761 189241794 XP_976078.2 1228 4.6e-132 PREDICTED: 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [Tribolium castaneum]>gi|270001159|gb|EEZ97606.1| hypothetical protein TcasGA2_TC011476 [Tribolium castaneum] 642937780 XM_970985.3 201 1.45535e-98 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 4 (LOC658092), transcript variant X2, mRNA K03029 PSMD4, RPN10 26S proteasome regulatory subunit N10 http://www.genome.jp/dbget-bin/www_bget?ko:K03029 Q58DA0 895 7.8e-95 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus GN=PSMD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2884 26S proteasome regulatory complex, subunit RPN10/PSMD4 Cluster-8309.35512 BP_3 1664.43 236.44 631 821003176 XP_012365190.1 1042 6.1e-111 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 768431775 XM_011558880.1 281 1.69935e-143 PREDICTED: Plutella xylostella polyubiquitin-A (LOC105388041), transcript variant X5, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 1042 2.5e-112 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560//PF04452 Ubiquitin family//Ubiquitin-like domain//RNA methyltransferase GO:0006364 rRNA processing GO:0005515//GO:0008168 protein binding//methyltransferase activity -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35513 BP_3 4891.70 400.80 880 353231251 CCD77669.1 924 4.1e-97 putative ubiquitin (ribosomal protein L40) [Schistosoma mansoni] 260830118 XM_002609963.1 308 2.35755e-158 Branchiostoma floridae hypothetical protein, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 919 6.4e-98 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF04452//PF00240//PF14560 RNA methyltransferase//Ubiquitin family//Ubiquitin-like domain GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35514 BP_3 1030.51 36.76 1643 642933218 XP_008197312.1 1256 2.4e-135 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 843 7.8e-89 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF04369//PF00083//PF00854 Major Facilitator Superfamily//Lactococcin-like family//Sugar (and other) transporter//POT family GO:0006810//GO:0042742//GO:0055085 transport//defense response to bacterium//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021//GO:0005576//GO:0016020 integral component of membrane//extracellular region//membrane -- -- Cluster-8309.35515 BP_3 149.46 4.67 1835 91081787 XP_973692.1 773 2.8e-79 PREDICTED: uncharacterized protein LOC662508 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05281 Neuroendocrine protein 7B2 precursor (Secretogranin V) GO:0007218 neuropeptide signaling pathway -- -- GO:0030141 secretory granule -- -- Cluster-8309.35517 BP_3 814.67 15.60 2808 478255416 ENN75638.1 1298 5.6e-140 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 987 2.7e-105 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 PF04627//PF00288 Mitochondrial ATP synthase epsilon chain//GHMP kinases N terminal domain GO:0015992//GO:0015986//GO:0006119 proton transport//ATP synthesis coupled proton transport//oxidative phosphorylation GO:0046933//GO:0046961//GO:0005524 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//ATP binding GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.35518 BP_3 5465.14 61.48 4576 642916846 XP_008199527.1 814 1.2e-83 PREDICTED: failed axon connections isoform X2 [Tribolium castaneum]>gi|270003072|gb|EEZ99519.1| hypothetical protein TcasGA2_TC000100 [Tribolium castaneum] 642916844 XM_963303.3 271 4.678e-137 PREDICTED: Tribolium castaneum failed axon connections (LOC656797), transcript variant X1, mRNA -- -- -- -- Q95RI5 693 5.4e-71 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF13417//PF05132//PF02724//PF06213//PF16834//PF02535//PF06459 Glutathione S-transferase, N-terminal domain//RNA polymerase III RPC4//CDC45-like protein//Cobalamin biosynthesis protein CobT//Shu complex component Csm2, DNA-binding//ZIP Zinc transporter//Ryanodine Receptor TM 4-6 GO:0006874//GO:0009236//GO:0006816//GO:0055085//GO:0006270//GO:0006206//GO:0000725//GO:0006351//GO:0030001//GO:0006383//GO:0006144 cellular calcium ion homeostasis//cobalamin biosynthetic process//calcium ion transport//transmembrane transport//DNA replication initiation//pyrimidine nucleobase metabolic process//recombinational repair//transcription, DNA-templated//metal ion transport//transcription from RNA polymerase III promoter//purine nucleobase metabolic process GO:0003899//GO:0046873//GO:0003677//GO:0005219//GO:0005515 DNA-directed RNA polymerase activity//metal ion transmembrane transporter activity//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding GO:0005622//GO:0005666//GO:0005730//GO:0016021//GO:0097196//GO:0016020//GO:0005634 intracellular//DNA-directed RNA polymerase III complex//nucleolus//integral component of membrane//Shu complex//membrane//nucleus -- -- Cluster-8309.35519 BP_3 1840.89 37.66 2648 642928387 XP_008192723.1 1186 5.1e-127 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Tribolium castaneum] 852728203 XM_013016081.1 97 1.43333e-40 PREDICTED: Dipodomys ordii dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), mRNA K00658 DLST, sucB 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) http://www.genome.jp/dbget-bin/www_bget?ko:K00658 Q90512 1089 3.7e-117 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (Fragment) OS=Takifugu rubripes GN=dlst PE=3 SV=1 PF07831//PF00198 Pyrimidine nucleoside phosphorylase C-terminal domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain) GO:0006213//GO:0008152 pyrimidine nucleoside metabolic process//metabolic process GO:0016746//GO:0016763 transferase activity, transferring acyl groups//transferase activity, transferring pentosyl groups -- -- KOG0559 Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) Cluster-8309.35520 BP_3 413.32 4.45 4767 642915350 XP_008190583.1 277 2.3e-21 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q86MW9 234 9.4e-18 E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni GN=SINA PE=1 SV=1 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.35521 BP_3 31.80 0.60 2839 478250432 ENN70927.1 576 3.0e-56 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] 645036882 XM_001607897.2 186 5.15071e-90 PREDICTED: Nasonia vitripennis histone H2A-like (LOC100114644), mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P84052 471 1.8e-45 Histone H2A OS=Drosophila erecta GN=His2A PE=3 SV=2 PF00656//PF00125//PF12513 Caspase domain//Core histone H2A/H2B/H3/H4//Mitochondrial degradasome RNA helicase subunit C terminal GO:0006508 proteolysis GO:0016817//GO:0004197//GO:0003677 hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//DNA binding -- -- -- -- Cluster-8309.35522 BP_3 548.25 89.78 586 270011805 EFA08253.1 223 5.3e-16 hypothetical protein TcasGA2_TC005881 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.35523 BP_3 862.01 18.47 2541 741829858 AJA91073.1 1786 1.3e-196 cytochrome P450 [Leptinotarsa decemlineata] 749794849 XM_011152479.1 40 6.6729e-09 PREDICTED: Harpegnathos saltator cytochrome P450 9e2-like (LOC105190010), mRNA K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1244 3.8e-135 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.35524 BP_3 259.30 5.28 2659 642938021 XP_008199174.1 3463 0.0e+00 PREDICTED: alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270015713|gb|EFA12161.1| hypothetical protein TcasGA2_TC002311 [Tribolium castaneum] -- -- -- -- -- K14157 AASS alpha-aminoadipic semialdehyde synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14157 A2VCW9 2123 4.7e-237 Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Rattus norvegicus GN=Aass PE=2 SV=1 PF01118//PF01113//PF02254//PF03435//PF03447//PF01408//PF13241//PF02826 Semialdehyde dehydrogenase, NAD binding domain//Dihydrodipicolinate reductase, N-terminus//TrkA-N domain//Saccharopine dehydrogenase NADP binding domain//Homoserine dehydrogenase, NAD binding domain//Oxidoreductase family, NAD-binding Rossmann fold//Putative NAD(P)-binding//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0009089//GO:0019354//GO:0009085//GO:0006813//GO:0006779//GO:0055114 lysine biosynthetic process via diaminopimelate//siroheme biosynthetic process//lysine biosynthetic process//potassium ion transport//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0043115//GO:0050661//GO:0008839//GO:0016491//GO:0051287//GO:0000166//GO:0016620 precorrin-2 dehydrogenase activity//NADP binding//4-hydroxy-tetrahydrodipicolinate reductase//oxidoreductase activity//NAD binding//nucleotide binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase Cluster-8309.35525 BP_3 19512.00 1455.24 938 556505461 YP_008757558.1 895 1.0e-93 cytochrome c oxidase subunit II (mitochondrion) [Batocera lineolata]>gi|359294284|gb|AEV21653.1| cytochrome c oxidase subunit II [Batocera lineolata] 359294281 JN986793.1 718 0 Batocera lineolata mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P98030 712 6.9e-74 Cytochrome c oxidase subunit 2 OS=Choristoneura rosaceana GN=COII PE=3 SV=1 PF02790//PF06305 Cytochrome C oxidase subunit II, transmembrane domain//Protein of unknown function (DUF1049) GO:0022900 electron transport chain -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.35526 BP_3 1178.75 26.78 2413 189235434 XP_001813433.1 2872 0.0e+00 PREDICTED: paraplegin [Tribolium castaneum]>gi|270004289|gb|EFA00737.1| hypothetical protein TcasGA2_TC003619 [Tribolium castaneum] 641666602 XM_001943555.3 54 1.04469e-16 PREDICTED: Acyrthosiphon pisum paraplegin (LOC100167726), mRNA K09552 SPG7 spastic paraplegia 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09552 Q9UQ90 1641 3.3e-181 Paraplegin OS=Homo sapiens GN=SPG7 PE=1 SV=2 PF00910//PF00005//PF07724//PF00004//PF01434//PF06480//PF05496//PF06068//PF01695//PF07728 RNA helicase//ABC transporter//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Peptidase family M41//FtsH Extracellular//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily) GO:0030163//GO:0006310//GO:0006508//GO:0006281 protein catabolic process//DNA recombination//proteolysis//DNA repair GO:0003723//GO:0003678//GO:0003724//GO:0017111//GO:0009378//GO:0004222//GO:0005524//GO:0008270//GO:0016887 RNA binding//DNA helicase activity//RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//metalloendopeptidase activity//ATP binding//zinc ion binding//ATPase activity GO:0005657//GO:0009379//GO:0016021 replication fork//Holliday junction helicase complex//integral component of membrane KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.35527 BP_3 116.92 3.63 1844 -- -- -- -- -- 642916156 XM_008192687.1 95 1.28363e-39 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35530 BP_3 32292.36 2542.16 904 166947673 ABZ04123.1 542 8.3e-53 putative cuticle protein CP6 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F1 289 7.4e-25 Endocuticle structural glycoprotein SgAbd-4 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.35532 BP_3 119.54 0.64 9264 570341960 AHE77377.1 2740 1.1e-306 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 905 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2669 8.1e-300 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF01370//PF01968//PF01223//PF00033//PF04625//PF06723//PF01194//PF02491//PF08303//PF01073//PF00106//PF05739//PF02782 NAD dependent epimerase/dehydratase family//Hydantoinase/oxoprolinase//DNA/RNA non-specific endonuclease//Cytochrome b/b6/petB//DEC-1 protein, N-terminal region//MreB/Mbl protein//RNA polymerases N / 8 kDa subunit//SHS2 domain inserted in FTSA//tRNA ligase kinase domain//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//SNARE domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0008207//GO:0000902//GO:0005975//GO:0055114//GO:0008210//GO:0006388//GO:0022904//GO:0008152//GO:0008209//GO:0007304//GO:0007049//GO:0006694//GO:0006206//GO:0006351//GO:0006144 C21-steroid hormone metabolic process//cell morphogenesis//carbohydrate metabolic process//oxidation-reduction process//estrogen metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain//metabolic process//androgen metabolic process//chorion-containing eggshell formation//cell cycle//steroid biosynthetic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0005524//GO:0003854//GO:0016616//GO:0003676//GO:0016773//GO:0046872//GO:0016491//GO:0016787//GO:0005213//GO:0050662//GO:0003899//GO:0003972//GO:0003677//GO:0003824//GO:0005515 ATP binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//nucleic acid binding//phosphotransferase activity, alcohol group as acceptor//metal ion binding//oxidoreductase activity//hydrolase activity//structural constituent of chorion//coenzyme binding//DNA-directed RNA polymerase activity//RNA ligase (ATP) activity//DNA binding//catalytic activity//protein binding GO:0005730//GO:0042600//GO:0016020//GO:0005576 nucleolus//chorion//membrane//extracellular region KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.35533 BP_3 258.00 73.74 460 642934836 XP_008197831.1 444 9.8e-42 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [Tribolium castaneum]>gi|270014373|gb|EFA10821.1| hypothetical protein TcasGA2_TC030694 [Tribolium castaneum] -- -- -- -- -- K03949 NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03949 P23935 309 1.8e-27 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Bos taurus GN=NDUFA5 PE=1 SV=3 PF04716 ETC complex I subunit conserved region GO:0022904 respiratory electron transport chain GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0005743 mitochondrial inner membrane KOG3365 NADH:ubiquinone oxidoreductase, NDUFA5/B13 subunit Cluster-8309.35535 BP_3 68.73 1.73 2208 170068019 XP_001868706.1 234 1.1e-16 conserved hypothetical protein [Culex quinquefasciatus]>gi|167864133|gb|EDS27516.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00513 Late Protein L2 -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.35537 BP_3 2067.92 41.77 2678 642934083 XP_008196496.1 1062 1.2e-112 PREDICTED: phosphatase and actin regulator 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 507 1.2e-49 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00344//PF00957 SecY translocase//Synaptobrevin GO:0016192//GO:0015031 vesicle-mediated transport//protein transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.35542 BP_3 3994.24 99.38 2229 478262445 ENN81116.1 766 2.2e-78 hypothetical protein YQE_02484, partial [Dendroctonus ponderosae]>gi|546673666|gb|ERL85230.1| hypothetical protein D910_02651 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q08C69 452 2.3e-43 RNA pseudouridylate synthase domain-containing protein 1 OS=Danio rerio GN=rpusd1 PE=2 SV=1 PF00849 RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG1919 RNA pseudouridylate synthases Cluster-8309.35545 BP_3 30.00 1.46 1282 642936684 XP_001807897.2 430 1.1e-39 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 176 1.3e-11 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF00060//PF00520//PF04647//PF05478 Ligand-gated ion channel//Ion transport protein//Accessory gene regulator B//Prominin GO:0007165//GO:0009405//GO:0055085//GO:0007268//GO:0009372//GO:0006811 signal transduction//pathogenesis//transmembrane transport//synaptic transmission//quorum sensing//ion transport GO:0004970//GO:0005216//GO:0008233 ionotropic glutamate receptor activity//ion channel activity//peptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.35546 BP_3 997.93 14.32 3650 270009295 EFA05743.1 468 1.3e-43 serine protease H164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9LK03 168 3.2e-10 Proline-rich receptor-like protein kinase PERK2 OS=Arabidopsis thaliana GN=PERK2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35547 BP_3 550.59 15.54 2000 270016446 EFA12892.1 1585 2.1e-173 hypothetical protein TcasGA2_TC004406 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q7Z2H8 754 2.0e-78 Proton-coupled amino acid transporter 1 OS=Homo sapiens GN=SLC36A1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.35548 BP_3 39.80 0.32 6255 91076598 XP_968579.1 3094 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 1.22598e-39 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 P30628 2013 6.3e-224 Probable V-type proton ATPase 116 kDa subunit a OS=Caenorhabditis elegans GN=unc-32 PE=2 SV=3 PF10417//PF03099//PF08653//PF01496 C-terminal domain of 1-Cys peroxiredoxin//Biotin/lipoate A/B protein ligase family//DASH complex subunit Dam1//V-type ATPase 116kDa subunit family GO:0008608//GO:0015992//GO:0055114//GO:0006464//GO:0015991 attachment of spindle microtubules to kinetochore//proton transport//oxidation-reduction process//cellular protein modification process//ATP hydrolysis coupled proton transport GO:0015078//GO:0051920 hydrogen ion transmembrane transporter activity//peroxiredoxin activity GO:0042729//GO:0033179//GO:0072686 DASH complex//proton-transporting V-type ATPase, V0 domain//mitotic spindle KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.35549 BP_3 443.82 3.84 5862 642935129 XP_008197899.1 458 3.0e-42 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- K14651 TAF15, NPL3 transcription initiation factor TFIID subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14651 Q27294 374 6.7e-34 RNA-binding protein cabeza OS=Drosophila melanogaster GN=caz PE=2 SV=2 PF00076//PF00641 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zn-finger in Ran binding protein and others -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG1995 Conserved Zn-finger protein Cluster-8309.35550 BP_3 148.27 3.33 2437 642928513 XP_008193822.1 1402 4.3e-152 PREDICTED: uncharacterized protein LOC659984 [Tribolium castaneum] 299884466 FP926002.1 78 4.80643e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51022 606 3.5e-61 ETS-like protein pointed, isoform P1 OS=Drosophila melanogaster GN=pnt PE=2 SV=1 PF00178//PF00447//PF02198 Ets-domain//HSF-type DNA-binding//Sterile alpha motif (SAM)/Pointed domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.35551 BP_3 266.77 1.58 8432 270006792 EFA03240.1 1430 8.3e-155 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] 332376113 BT128237.1 195 1.53129e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 870 3.0e-91 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF05493//PF07994//PF00595//PF13180//PF00412 ATP synthase subunit H//Myo-inositol-1-phosphate synthase//PDZ domain (Also known as DHR or GLGF)//PDZ domain//LIM domain GO:0008654//GO:0015992//GO:0019872//GO:0015991//GO:0006021 phospholipid biosynthetic process//proton transport//streptomycin biosynthetic process//ATP hydrolysis coupled proton transport//inositol biosynthetic process GO:0015078//GO:0008270//GO:0004512//GO:0005515 hydrogen ion transmembrane transporter activity//zinc ion binding//inositol-3-phosphate synthase activity//protein binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35552 BP_3 371.25 7.01 2845 642928513 XP_008193822.1 1402 5.0e-152 PREDICTED: uncharacterized protein LOC659984 [Tribolium castaneum] 299884466 FP926002.1 78 5.61908e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51022 606 4.1e-61 ETS-like protein pointed, isoform P1 OS=Drosophila melanogaster GN=pnt PE=2 SV=1 PF02198//PF00447//PF00178 Sterile alpha motif (SAM)/Pointed domain//HSF-type DNA-binding//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.35553 BP_3 829.37 5.36 7752 642924436 XP_008194297.1 1103 6.3e-117 PREDICTED: PDZ and LIM domain protein Zasp [Tribolium castaneum] 332376113 BT128237.1 195 1.40725e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 954 4.9e-101 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF08782//PF13180//PF00412//PF15247//PF05493 PDZ domain (Also known as DHR or GLGF)//c-SKI Smad4 binding domain//PDZ domain//LIM domain//Histone RNA hairpin-binding protein RNA-binding domain//ATP synthase subunit H GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0046332//GO:0008270//GO:0015078//GO:0005515//GO:0003723 SMAD binding//zinc ion binding//hydrogen ion transmembrane transporter activity//protein binding//RNA binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35555 BP_3 1752.92 43.28 2244 91076006 XP_966406.1 2629 2.1e-294 PREDICTED: very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014595|gb|EFA11043.1| hypothetical protein TcasGA2_TC004634 [Tribolium castaneum] 676425561 XM_009046107.1 184 5.25255e-89 Lottia gigantea hypothetical protein partial mRNA K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 Q8HXY7 1881 4.6e-209 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Macaca fascicularis GN=ACADVL PE=2 SV=1 PF02770//PF00441//PF02771 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.35556 BP_3 214.69 1.10 9659 815897760 XP_012249603.1 195 1.5e-11 PREDICTED: gastrula zinc finger protein XlCGF26.1-like [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q96PQ6 148 1.8e-07 Zinc finger protein 317 OS=Homo sapiens GN=ZNF317 PE=1 SV=2 PF13465//PF02176//PF00096//PF16622//PF01428//PF02892 Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type//zinc-finger C2H2-type//AN1-like Zinc finger//BED zinc finger -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.35557 BP_3 316.00 12.58 1502 91080431 XP_968599.1 429 1.8e-39 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35559 BP_3 335.00 661.34 297 820969389 XP_012370642.1 498 3.5e-48 PREDICTED: LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [Octodon degus] 655477108 KJ785957.1 189 1.04368e-92 Gonioctena intermedia isolate h11 beta-actin gene, partial cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 O18840 498 1.4e-49 Actin, cytoplasmic 1 OS=Canis familiaris GN=ACTB PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.35561 BP_3 19.05 0.68 1636 91086841 XP_974159.1 749 1.5e-76 PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum]>gi|642929084|ref|XP_008195684.1| PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum] -- -- -- -- -- K11205 GCLM glutamate--cysteine ligase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11205 P48508 336 4.8e-30 Glutamate--cysteine ligase regulatory subunit OS=Rattus norvegicus GN=Gclm PE=1 SV=1 PF02020//PF00433 eIF4-gamma/eIF5/eIF2-epsilon//Protein kinase C terminal domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004674//GO:0005515//GO:0005524 protein serine/threonine kinase activity//protein binding//ATP binding -- -- KOG3023 Glutamate-cysteine ligase regulatory subunit Cluster-8309.35563 BP_3 23.20 0.32 3744 478258440 ENN78530.1 458 1.9e-42 hypothetical protein YQE_05004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q55BM1 131 6.5e-06 Probable inactive protein kinase DDB_G0270444 OS=Dictyostelium discoideum GN=DDB_G0270444 PE=1 SV=1 PF04210//PF02601//PF05478//PF01442 Tetrahydromethanopterin S-methyltransferase, subunit G//Exonuclease VII, large subunit//Prominin//Apolipoprotein A1/A4/E domain GO:0006308//GO:0015948//GO:0042157//GO:0006869//GO:0046656 DNA catabolic process//methanogenesis//lipoprotein metabolic process//lipid transport//folic acid biosynthetic process GO:0008289//GO:0030269//GO:0008855 lipid binding//tetrahydromethanopterin S-methyltransferase activity//exodeoxyribonuclease VII activity GO:0009318//GO:0005576//GO:0016021 exodeoxyribonuclease VII complex//extracellular region//integral component of membrane -- -- Cluster-8309.35564 BP_3 152.00 15.45 766 546684890 ERL94472.1 485 2.9e-46 hypothetical protein D910_11749 [Dendroctonus ponderosae] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q9D4D4 384 6.1e-36 Transketolase-like protein 2 OS=Mus musculus GN=Tktl2 PE=2 SV=1 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0523 Transketolase Cluster-8309.35565 BP_3 300.00 50.85 576 642924564 XP_008194345.1 379 4.2e-34 PREDICTED: reactive oxygen species modulator 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4QNF3 280 5.2e-24 Reactive oxygen species modulator 1 OS=Xenopus tropicalis GN=romo1 PE=3 SV=1 PF10439 Bacteriocin class II with double-glycine leader peptide GO:0042742 defense response to bacterium -- -- -- -- KOG4096 Uncharacterized conserved protein Cluster-8309.35567 BP_3 63.75 3.07 1291 642930671 XP_008199218.1 636 1.5e-63 PREDICTED: uncharacterized protein LOC100142507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35568 BP_3 284.96 15.11 1201 478250970 ENN71454.1 862 8.6e-90 hypothetical protein YQE_11872, partial [Dendroctonus ponderosae]>gi|546682661|gb|ERL92573.1| hypothetical protein D910_09886 [Dendroctonus ponderosae] -- -- -- -- -- K15143 MED30 mediator of RNA polymerase II transcription subunit 30 http://www.genome.jp/dbget-bin/www_bget?ko:K15143 Q172Y1 529 1.5e-52 Mediator of RNA polymerase II transcription subunit 30 OS=Aedes aegypti GN=MED30 PE=3 SV=1 PF03153//PF04546 Transcription factor IIA, alpha/beta subunit//Sigma-70, non-essential region GO:0006352//GO:0006367//GO:0006355 DNA-templated transcription, initiation//transcription initiation from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0016987 DNA binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667//GO:0005672 transcription factor complex//transcription factor TFIIA complex -- -- Cluster-8309.35569 BP_3 58.67 1.05 2983 546682375 ERL92317.1 1068 2.8e-113 hypothetical protein D910_09634 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V771 749 1.1e-77 Probable cytochrome P450 6a23 OS=Drosophila melanogaster GN=Cyp6a23 PE=2 SV=2 PF00067//PF02428 Cytochrome P450//Potato type II proteinase inhibitor family GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0004867//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//serine-type endopeptidase inhibitor activity//heme binding -- -- -- -- Cluster-8309.35571 BP_3 4846.49 47.61 5198 642913457 XP_008201020.1 1887 5.2e-208 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 817221636 XM_012430865.1 450 0 PREDICTED: Orussus abietinus ankyrin repeat domain-containing protein 17 (LOC105702908), mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q9VCA8 1678 3.7e-185 Ankyrin repeat and KH domain-containing protein mask OS=Drosophila melanogaster GN=mask PE=1 SV=2 PF07650//PF00023//PF00013//PF07931//PF13606//PF13014 KH domain//Ankyrin repeat//KH domain//Chloramphenicol phosphotransferase-like protein//Ankyrin repeat//KH domain -- -- GO:0005515//GO:0005524//GO:0003723//GO:0016740 protein binding//ATP binding//RNA binding//transferase activity -- -- -- -- Cluster-8309.35573 BP_3 478.32 14.49 1883 478252002 ENN72437.1 1353 1.6e-146 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 142 9.78471e-66 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 919 1.4e-97 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF00013//PF08273//PF03604//PF13014//PF00098//PF00275//PF16588 KH domain//Zinc-binding domain of primase-helicase//DNA directed RNA polymerase, 7 kDa subunit//KH domain//Zinc knuckle//EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)//C2H2 zinc-finger GO:0006351//GO:0006144//GO:0006206//GO:0006269 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//DNA replication, synthesis of RNA primer GO:0003677//GO:0003896//GO:0003723//GO:0004386//GO:0003899//GO:0003676//GO:0008270//GO:0016765 DNA binding//DNA primase activity//RNA binding//helicase activity//DNA-directed RNA polymerase activity//nucleic acid binding//zinc ion binding//transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.35574 BP_3 59.65 2.12 1648 332375941 AEE63111.1 1000 1.2e-105 unknown [Dendroctonus ponderosae]>gi|478258807|gb|ENN78823.1| hypothetical protein YQE_04722, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.35575 BP_3 6623.13 93.97 3689 91088689 XP_974981.1 1095 2.6e-116 PREDICTED: protein phosphatase 1 regulatory subunit 7 [Tribolium castaneum] 332373161 BT126760.1 197 5.15262e-96 Dendroctonus ponderosae clone DPO1116_A05 unknown mRNA K17550 PPP1R7, SDS22 protein phosphatase 1 regulatory subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17550 Q5HZV9 759 9.6e-79 Protein phosphatase 1 regulatory subunit 7 OS=Rattus norvegicus GN=Ppp1r7 PE=1 SV=1 PF01287//PF00560//PF13855 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//Leucine Rich Repeat//Leucine rich repeat GO:0006452//GO:0006448//GO:0045905//GO:0045901 translational frameshifting//regulation of translational elongation//positive regulation of translational termination//positive regulation of translational elongation GO:0043022//GO:0003723//GO:0005515//GO:0003746 ribosome binding//RNA binding//protein binding//translation elongation factor activity GO:0005840 ribosome KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.35576 BP_3 3349.15 42.42 4097 189234578 XP_974655.2 1464 4.6e-159 PREDICTED: glucosidase 2 subunit beta [Tribolium castaneum] 760445822 XM_011401678.1 38 1.39838e-07 Auxenochlorella protothecoides Protein disulfide-isomerase 1 partial mRNA K13984 TXNDC5, ERP46 thioredoxin domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13984 O08795 931 1.2e-98 Glucosidase 2 subunit beta OS=Mus musculus GN=Prkcsh PE=1 SV=1 PF00578//PF13202//PF00036//PF03015//PF00085//PF00057//PF04111//PF13499//PF13405//PF04147//PF13833 AhpC/TSA family//EF hand//EF hand//Male sterility protein//Thioredoxin//Low-density lipoprotein receptor domain class A//Autophagy protein Apg6//EF-hand domain pair//EF-hand domain//Nop14-like family//EF-hand domain pair GO:0006914//GO:0055114//GO:0045454 autophagy//oxidation-reduction process//cell redox homeostasis GO:0016491//GO:0005515//GO:0005509//GO:0016209//GO:0080019 oxidoreductase activity//protein binding//calcium ion binding//antioxidant activity//fatty-acyl-CoA reductase (alcohol-forming) activity GO:0032040 small-subunit processome KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.35578 BP_3 4821.90 23.25 10287 546672491 ERL84327.1 5652 0.0e+00 hypothetical protein D910_01746, partial [Dendroctonus ponderosae] 642918533 XM_008193290.1 118 1.19076e-51 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- O01761 764 7.1e-79 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF02480 Immunoglobulin domain//Alphaherpesvirus glycoprotein E -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.35579 BP_3 1034.02 38.42 1589 478252744 ENN73138.1 1260 8.1e-136 hypothetical protein YQE_10242, partial [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 946 8.6e-101 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.35580 BP_3 314.80 3.14 5125 642930284 XP_008196328.1 878 5.2e-91 PREDICTED: fanconi-associated nuclease 1 homolog isoform X1 [Tribolium castaneum]>gi|270010701|gb|EFA07149.1| hypothetical protein TcasGA2_TC010140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LWH4 392 4.8e-36 Fanconi-associated nuclease 1 OS=Danio rerio GN=fan1 PE=2 SV=2 PF08774 VRR-NUC domain -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2143 Uncharacterized conserved protein Cluster-8309.35581 BP_3 301.50 3.56 4374 189238033 XP_966902.2 1533 4.9e-167 PREDICTED: transmembrane protein 185A [Tribolium castaneum]>gi|270008773|gb|EFA05221.1| hypothetical protein TcasGA2_TC015362 [Tribolium castaneum] 642925153 XM_961809.3 270 1.60765e-136 PREDICTED: Tribolium castaneum transmembrane protein 185A (LOC655280), mRNA -- -- -- -- Q8R3R5 891 5.6e-94 Transmembrane protein 185B OS=Mus musculus GN=Tmem185b PE=2 SV=1 PF01757//PF02535 Acyltransferase family//ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0016747//GO:0046873 transferase activity, transferring acyl groups other than amino-acyl groups//metal ion transmembrane transporter activity GO:0016020 membrane KOG3907 ZIP-like zinc transporter proteins Cluster-8309.35583 BP_3 312.12 10.47 1729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.35585 BP_3 23736.53 329.21 3767 148230813 NP_001083770.1 359 5.8e-31 microtubule-associated protein 4 [Xenopus laevis]>gi|4063005|dbj|BAA36221.1| XMAP4 [Xenopus laevis] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 O42854 189 1.2e-12 SH3 domain-containing protein C23A1.17 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC23A1.17 PE=1 SV=1 PF02730 Aldehyde ferredoxin oxidoreductase, N-terminal domain GO:0055114 oxidation-reduction process GO:0016625//GO:0051536//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//iron-sulfur cluster binding//oxidoreductase activity -- -- -- -- Cluster-8309.35586 BP_3 1251.00 21.93 3041 270004722 EFA01170.1 189 2.4e-11 hypothetical protein TcasGA2_TC010493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35587 BP_3 9.93 0.87 845 332375456 AEE62869.1 570 4.4e-56 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 104 5.71593e-45 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 531 6.0e-53 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF00224 Pyruvate kinase, barrel domain GO:0006144//GO:0015976//GO:0006094//GO:0006096 purine nucleobase metabolic process//carbon utilization//gluconeogenesis//glycolytic process GO:0000287//GO:0004743//GO:0030955 magnesium ion binding//pyruvate kinase activity//potassium ion binding -- -- KOG2323 Pyruvate kinase Cluster-8309.35588 BP_3 411.14 13.94 1713 642935906 XP_008198223.1 2115 6.3e-235 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 768415454 XM_011549976.1 627 0 PREDICTED: Plutella xylostella calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC105380420), transcript variant X5, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 Q7PPA5 2015 1.0e-224 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Anopheles gambiae GN=Ca-P60A PE=3 SV=5 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.3559 BP_3 2.00 0.48 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35590 BP_3 8985.49 1644.52 555 264667323 ACY71247.1 756 7.8e-78 ribosomal protein S13 [Chrysomela tremula] 26190492 AY174891.1 124 2.79875e-56 Plutella xylostella ribosomal protein S13 mRNA, complete cds K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 Q962R6 713 3.1e-74 40S ribosomal protein S13 OS=Spodoptera frugiperda GN=RpS13 PE=2 SV=3 PF08069//PF00312 Ribosomal S13/S15 N-terminal domain//Ribosomal protein S15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0400 40S ribosomal protein S13 Cluster-8309.35591 BP_3 3273.76 27.74 5979 270004228 EFA00676.1 1956 6.0e-216 hypothetical protein TcasGA2_TC003553 [Tribolium castaneum] 642916460 XM_008192815.1 144 2.43176e-66 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 P58006 1177 5.3e-127 Sestrin-1 OS=Mus musculus GN=Sesn1 PE=2 SV=3 PF04636//PF08683 PA26 p53-induced protein (sestrin)//Microtubule-binding calmodulin-regulated spectrin-associated GO:1901031 regulation of response to reactive oxygen species GO:0008017 microtubule binding GO:0045298//GO:0005634 tubulin complex//nucleus KOG3746 Uncharacterized conserved protein Cluster-8309.35592 BP_3 15.00 0.50 1749 332376705 AEE63492.1 543 1.2e-52 unknown [Dendroctonus ponderosae] 332376704 BT128535.1 250 8.33657e-126 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 450 3.1e-43 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF09416//PF00992 RNA helicase (UPF2 interacting domain)//Troponin GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0003677//GO:0008270//GO:0005524//GO:0004386 DNA binding//zinc ion binding//ATP binding//helicase activity GO:0005737//GO:0005861 cytoplasm//troponin complex KOG3977 Troponin I Cluster-8309.35596 BP_3 1591.34 35.07 2479 478251025 ENN71506.1 1061 1.5e-112 hypothetical protein YQE_11799, partial [Dendroctonus ponderosae]>gi|546679474|gb|ERL89938.1| hypothetical protein D910_07297 [Dendroctonus ponderosae] -- -- -- -- -- K10052 CEBPN CCAAT/enhancer binding protein (C/EBP), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K10052 Q02637 261 3.6e-21 CCAAT/enhancer-binding protein OS=Drosophila melanogaster GN=slbo PE=1 SV=3 PF00170//PF07716//PF11023//PF04960 bZIP transcription factor//Basic region leucine zipper//Zinc-ribbon containing domain//Glutaminase GO:0006355//GO:0006541 regulation of transcription, DNA-templated//glutamine metabolic process GO:0043565//GO:0004359//GO:0003700 sequence-specific DNA binding//glutaminase activity//transcription factor activity, sequence-specific DNA binding GO:0005887//GO:0005667 integral component of plasma membrane//transcription factor complex -- -- Cluster-8309.35598 BP_3 12.52 0.47 1573 642930671 XP_008199218.1 628 1.5e-62 PREDICTED: uncharacterized protein LOC100142507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35599 BP_3 6.00 4.16 357 741829858 AJA91073.1 464 3.6e-44 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 352 1.5e-32 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.356 BP_3 13.90 3.97 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35600 BP_3 3780.00 325.77 851 332376312 AEE63296.1 687 1.2e-69 unknown [Dendroctonus ponderosae] 332376311 BT128338.1 35 1.30971e-06 Dendroctonus ponderosae clone DPO1410_H07 unknown mRNA -- -- -- -- Q00649 201 1.1e-14 Heat shock protein beta-1 OS=Gallus gallus GN=HSPB1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.35601 BP_3 6.00 0.46 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35603 BP_3 1232.78 11.86 5301 642936172 XP_008198327.1 3060 0.0e+00 PREDICTED: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [Tribolium castaneum]>gi|270014057|gb|EFA10505.1| hypothetical protein TcasGA2_TC012753 [Tribolium castaneum] -- -- -- -- -- K12489 ACAP Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12489 Q6IVG4 1615 7.6e-178 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Oryctolagus cuniculus GN=ACAP2 PE=2 SV=1 PF01412//PF00023//PF03114//PF13606//PF02170 Putative GTPase activating protein for Arf//Ankyrin repeat//BAR domain//Ankyrin repeat//PAZ domain -- -- GO:0005515//GO:0005543//GO:0005096//GO:0008270//GO:0019904 protein binding//phospholipid binding//GTPase activator activity//zinc ion binding//protein domain specific binding GO:0005737 cytoplasm KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.35604 BP_3 4890.85 199.22 1475 91090290 XP_971485.1 977 4.9e-103 PREDICTED: bax inhibitor 1 [Tribolium castaneum]>gi|270013796|gb|EFA10244.1| hypothetical protein TcasGA2_TC012443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7R1 591 1.2e-59 Bax inhibitor 1 OS=Pongo abelii GN=TMBIM6 PE=2 SV=2 -- -- GO:0043066 negative regulation of apoptotic process -- -- GO:0016021 integral component of membrane KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1 Cluster-8309.35605 BP_3 1132.68 23.03 2662 91088615 XP_974002.1 834 3.4e-86 PREDICTED: sepiapterin reductase [Tribolium castaneum]>gi|270012265|gb|EFA08713.1| hypothetical protein TcasGA2_TC006384 [Tribolium castaneum] -- -- -- -- -- K00072 SPR sepiapterin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00072 P35270 313 3.6e-27 Sepiapterin reductase OS=Homo sapiens GN=SPR PE=1 SV=1 PF05130//PF12242//PF00769//PF00106 FlgN protein//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Ezrin/radixin/moesin family//short chain dehydrogenase GO:0055114//GO:0008152//GO:0044780 oxidation-reduction process//metabolic process//bacterial-type flagellum assembly GO:0016491//GO:0008092 oxidoreductase activity//cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane KOG1204 Predicted dehydrogenase Cluster-8309.35606 BP_3 231.00 10.63 1339 270013242 EFA09690.1 1424 6.6e-155 hypothetical protein TcasGA2_TC011818 [Tribolium castaneum] -- -- -- -- -- K02257 COX10 protoheme IX farnesyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K02257 Q8CFY5 809 5.5e-85 Protoheme IX farnesyltransferase, mitochondrial OS=Mus musculus GN=Cox10 PE=2 SV=1 PF01040 UbiA prenyltransferase family -- -- GO:0004659 prenyltransferase activity GO:0016021 integral component of membrane KOG1380 Heme A farnesyltransferase Cluster-8309.35607 BP_3 847.46 8.12 5320 642919164 XP_008191764.1 1586 4.3e-173 PREDICTED: forkhead box protein N3-like isoform X2 [Tribolium castaneum] 642919163 XM_008193542.1 45 2.33709e-11 PREDICTED: Tribolium castaneum forkhead box protein N3-like (LOC100141565), transcript variant X5, mRNA K09407 FOXN forkhead box protein N http://www.genome.jp/dbget-bin/www_bget?ko:K09407 Q499D0 451 7.2e-43 Forkhead box protein N3 OS=Mus musculus GN=Foxn3 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.35608 BP_3 943.53 24.26 2166 642918239 XP_008191425.1 661 3.2e-66 PREDICTED: protein enabled isoform X2 [Tribolium castaneum] 642918238 XM_008193203.1 203 1.38904e-99 PREDICTED: Tribolium castaneum protein enabled (LOC658784), transcript variant X2, mRNA K05746 ENAH, MENA enabled http://www.genome.jp/dbget-bin/www_bget?ko:K05746 Q8T4F7 463 1.2e-44 Protein enabled OS=Drosophila melanogaster GN=ena PE=1 SV=4 PF12235//PF00638 Fragile X-related 1 protein core C terminal//RanBP1 domain GO:0046907 intracellular transport GO:0003723 RNA binding -- -- KOG4590 Signal transduction protein Enabled, contains WH1 domain Cluster-8309.35609 BP_3 1325.48 24.02 2952 332374224 AEE62253.1 1574 5.8e-172 unknown [Dendroctonus ponderosae] 662188737 XM_008489835.1 98 4.44593e-41 PREDICTED: Diaphorina citri elongation factor Tu, mitochondrial (LOC103524802), mRNA K02358 tuf, TUFM elongation factor Tu http://www.genome.jp/dbget-bin/www_bget?ko:K02358 P49411 1138 8.7e-123 Elongation factor Tu, mitochondrial OS=Homo sapiens GN=TUFM PE=1 SV=2 PF00231//PF02602//PF00894//PF01926//PF05165//PF03144 ATP synthase//Uroporphyrinogen-III synthase HemD//Luteovirus coat protein//50S ribosome-binding GTPase//GTP cyclohydrolase III//Elongation factor Tu domain 2 GO:0033014//GO:0015994//GO:0006119//GO:0006807//GO:0006783//GO:0015986//GO:0009058//GO:0015992 tetrapyrrole biosynthetic process//chlorophyll metabolic process//oxidative phosphorylation//nitrogen compound metabolic process//heme biosynthetic process//ATP synthesis coupled proton transport//biosynthetic process//proton transport GO:0003933//GO:0005525//GO:0005198//GO:0004852//GO:0046961//GO:0046933 GTP cyclohydrolase activity//GTP binding//structural molecule activity//uroporphyrinogen-III synthase activity//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045261//GO:0045259//GO:0019028 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex//viral capsid KOG0460 Mitochondrial translation elongation factor Tu Cluster-8309.35610 BP_3 2238.83 91.74 1468 332372901 AEE61592.1 1248 1.8e-134 unknown [Dendroctonus ponderosae]>gi|478260309|gb|ENN80061.1| hypothetical protein YQE_03537, partial [Dendroctonus ponderosae]>gi|546678011|gb|ERL88735.1| hypothetical protein D910_06117 [Dendroctonus ponderosae] 859814967 XM_013059117.1 74 4.79826e-28 PREDICTED: Mustela putorius furo ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1), transcript variant X5, mRNA K02136 ATPeF1G, ATP5C1, ATP3 F-type H+-transporting ATPase subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K02136 O01666 1060 4.8e-114 ATP synthase subunit gamma, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-gamma PE=2 SV=2 PF00231//PF00894//PF02602//PF05165 ATP synthase//Luteovirus coat protein//Uroporphyrinogen-III synthase HemD//GTP cyclohydrolase III GO:0015992//GO:0009058//GO:0033014//GO:0006119//GO:0015994//GO:0015986//GO:0006783//GO:0006807 proton transport//biosynthetic process//tetrapyrrole biosynthetic process//oxidative phosphorylation//chlorophyll metabolic process//ATP synthesis coupled proton transport//heme biosynthetic process//nitrogen compound metabolic process GO:0005198//GO:0046933//GO:0004852//GO:0046961//GO:0003933 structural molecule activity//proton-transporting ATP synthase activity, rotational mechanism//uroporphyrinogen-III synthase activity//proton-transporting ATPase activity, rotational mechanism//GTP cyclohydrolase activity GO:0019028//GO:0045259//GO:0045261 viral capsid//proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1531 F0F1-type ATP synthase, gamma subunit Cluster-8309.35614 BP_3 1199.00 88.60 944 91081971 XP_967978.1 413 7.9e-38 PREDICTED: plexin domain-containing protein 2 [Tribolium castaneum]>gi|270007319|gb|EFA03767.1| hypothetical protein TcasGA2_TC013878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91ZV7 242 2.2e-19 Plexin domain-containing protein 1 OS=Mus musculus GN=Plxdc1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3848 Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) Cluster-8309.35615 BP_3 34.09 1.10 1791 270008621 EFA05069.1 153 2.1e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35616 BP_3 103.83 3.61 1679 270008621 EFA05069.1 151 3.4e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.35618 BP_3 1077.00 58.70 1176 270002311 EEZ98758.1 803 5.9e-83 hypothetical protein TcasGA2_TC001322 [Tribolium castaneum] -- -- -- -- -- K17795 TIM17 mitochondrial import inner membrane translocase subunit TIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17795 O60830 597 1.9e-60 Mitochondrial import inner membrane translocase subunit Tim17-B OS=Homo sapiens GN=TIMM17B PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1652 Mitochondrial import inner membrane translocase, subunit TIM17 Cluster-8309.35619 BP_3 253.51 8.60 1712 91084399 XP_966650.1 835 1.7e-86 PREDICTED: protein FAM57A isoform X1 [Tribolium castaneum]>gi|270008835|gb|EFA05283.1| hypothetical protein TcasGA2_TC015440 [Tribolium castaneum] 194890120 XM_001977204.1 49 4.43398e-14 Drosophila erecta GG18353 (Dere\GG18353), mRNA -- -- -- -- Q5ND56 258 5.5e-21 Protein FAM57A OS=Mus musculus GN=Fam57a PE=3 SV=1 PF03798 TLC domain -- -- -- -- GO:0016021 integral component of membrane KOG4561 Uncharacterized conserved protein, contains TBC domain Cluster-8309.35620 BP_3 1103.02 32.45 1930 150416589 ABF60888.2 211 4.3e-14 putative glycine-rich protein [Leptinotarsa decemlineata]>gi|157649942|gb|ABV59365.1| glycine-rich protein variant 2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.35621 BP_3 62.00 6.20 774 765151967 XP_011486295.1 155 5.3e-08 PREDICTED: low-density lipoprotein receptor-related protein 2-like isoform X1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- A2ARV4 149 1.1e-08 Low-density lipoprotein receptor-related protein 2 OS=Mus musculus GN=Lrp2 PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.35623 BP_3 1217.76 24.33 2704 91087669 XP_973734.1 622 1.3e-61 PREDICTED: myosin-2 essential light chain isoform X2 [Tribolium castaneum]>gi|270009413|gb|EFA05861.1| hypothetical protein TcasGA2_TC008661 [Tribolium castaneum] 642930376 XM_968641.2 139 6.57032e-64 PREDICTED: Tribolium castaneum myosin-2 essential light chain (LOC662551), transcript variant X2, mRNA K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 P54357 537 3.9e-53 Myosin-2 essential light chain OS=Drosophila melanogaster GN=Mlc-c PE=1 SV=1 PF13499//PF13833//PF00036//PF13405//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.35624 BP_3 93.00 3.07 1751 546684978 ERL94552.1 643 3.1e-64 hypothetical protein D910_11829 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35626 BP_3 322.67 8.41 2141 91080237 XP_972872.1 868 3.1e-90 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35627 BP_3 205.00 1.49 6920 270003816 EFA00264.1 225 3.7e-15 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04060//PF07975//PF13465//PF04777//PF16622//PF13912//PF01363//PF00412//PF02892//PF00096//PF02176//PF14634//PF00643 Putative Fe-S cluster//TFIIH C1-like domain//Zinc-finger double domain//Erv1 / Alr family//zinc-finger C2H2-type//C2H2-type zinc finger//FYVE zinc finger//LIM domain//BED zinc finger//Zinc finger, C2H2 type//TRAF-type zinc finger//zinc-RING finger domain//B-box zinc finger GO:0055114//GO:0006281 oxidation-reduction process//DNA repair GO:0046872//GO:0016972//GO:0008270//GO:0051536//GO:0005515//GO:0003677 metal ion binding//thiol oxidase activity//zinc ion binding//iron-sulfur cluster binding//protein binding//DNA binding GO:0005622 intracellular -- -- Cluster-8309.35629 BP_3 773.11 25.68 1743 91078980 XP_974492.1 1933 8.1e-214 PREDICTED: cyclin-dependent kinase 10 [Tribolium castaneum]>gi|270004165|gb|EFA00613.1| hypothetical protein TcasGA2_TC003488 [Tribolium castaneum] 642916245 XM_969399.2 355 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 10 (LOC663347), mRNA K02449 CDK10 cyclin-dependent kinase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K02449 Q3UMM4 1335 7.3e-146 Cyclin-dependent kinase 10 OS=Mus musculus GN=Cdk10 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.35631 BP_3 1004.21 25.05 2224 642924941 XP_967306.2 1340 6.0e-145 PREDICTED: uncharacterized protein LOC658255 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53184 285 5.3e-24 Nicotinamidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNC1 PE=1 SV=1 PF00036//PF13202//PF00857//PF13499//PF13833//PF10591//PF13405//PF12763 EF hand//EF hand//Isochorismatase family//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Cytoskeletal-regulatory complex EF hand GO:0008152//GO:0007165 metabolic process//signal transduction GO:0005515//GO:0003824//GO:0005509 protein binding//catalytic activity//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4003 Pyrazinamidase/nicotinamidase PNC1 Cluster-8309.35632 BP_3 89.04 0.47 9376 642932804 XP_008196990.1 7075 0.0e+00 PREDICTED: myosin heavy chain, non-muscle isoform X1 [Tribolium castaneum] 462326123 APGK01041549.1 824 0 Dendroctonus ponderosae Seq01041559, whole genome shotgun sequence K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 5949 0.0e+00 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF01576//PF08471//PF00063//PF03222//PF00612 Myosin tail//Class II vitamin B12-dependent ribonucleotide reductase//Myosin head (motor domain)//Tryptophan/tyrosine permease family//IQ calmodulin-binding motif GO:0055114//GO:0006206//GO:0003333//GO:0006144//GO:0009186 oxidation-reduction process//pyrimidine nucleobase metabolic process//amino acid transmembrane transport//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process GO:0050897//GO:0003774//GO:0004748//GO:0005515//GO:0005524 cobalt ion binding//motor activity//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//protein binding//ATP binding GO:0005971//GO:0016459 ribonucleoside-diphosphate reductase complex//myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.35633 BP_3 167.40 2.04 4243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01386 Ribosomal L25p family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0008097 structural constituent of ribosome//5S rRNA binding GO:0005840 ribosome -- -- Cluster-8309.35636 BP_3 16.66 0.33 2690 91076230 XP_972985.1 526 1.8e-50 PREDICTED: synaptoporin [Tribolium castaneum]>gi|642911829|ref|XP_008200762.1| PREDICTED: synaptoporin [Tribolium castaneum]>gi|270014547|gb|EFA10995.1| hypothetical protein TcasGA2_TC004580 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5YJC1 313 3.6e-27 Synaptophysin OS=Spermophilus citellus GN=SYP PE=2 SV=1 PF01284//PF00654 Membrane-associating domain//Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane -- -- Cluster-8309.35637 BP_3 67.70 1.51 2457 270010228 EFA06676.1 389 1.2e-34 hypothetical protein TcasGA2_TC009606 [Tribolium castaneum] 366039975 NM_001256069.1 128 7.77279e-58 Tribolium castaneum ornithine decarboxylase antizyme az (az), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35639 BP_3 485.43 12.59 2150 607303042 EZA44934.1 957 1.5e-100 Zinc-finger C2H2 domain and EB module-containing protein [Microplitis demolitor] -- -- -- -- -- -- -- -- -- Q6ZMW2 404 8.2e-38 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF16622//PF07776//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.35641 BP_3 1234.85 21.13 3109 225543476 NP_001139385.1 1555 9.8e-170 ventral vein lacking [Tribolium castaneum]>gi|270008227|gb|EFA04675.1| ventral veins lacking [Tribolium castaneum] 225543475 NM_001145913.1 483 0 Tribolium castaneum ventral vein lacking (Vvl), mRNA K09365 POU3F, OTF POU domain transcription factor, class 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09365 P16241 1007 1.4e-107 POU domain protein CF1A OS=Drosophila melanogaster GN=vvl PE=2 SV=5 PF00046//PF00157//PF05920 Homeobox domain//Pou domain - N-terminal to homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.35642 BP_3 341.43 1.71 9902 91092056 XP_970271.1 4135 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] 157125487 XM_001654304.1 70 5.52395e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 3356 0.0e+00 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF03184//PF05225//PF04545//PF02796//PF01180//PF00196//PF00070//PF04218//PF01704//PF07992//PF01593//PF01884//PF06574//PF01207 DDE superfamily endonuclease//helix-turn-helix, Psq domain//Sigma-70, region 4//Helix-turn-helix domain of resolvase//Dihydroorotate dehydrogenase//Bacterial regulatory proteins, luxR family//Pyridine nucleotide-disulphide oxidoreductase//CENP-B N-terminal DNA-binding domain//UTP--glucose-1-phosphate uridylyltransferase//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//PcrB family//FAD synthetase//Dihydrouridine synthase (Dus) GO:0006207//GO:0055114//GO:0008033//GO:0006355//GO:0006118//GO:0009231//GO:0006222//GO:0008152//GO:0006352//GO:0006310//GO:0006771//GO:0006206 'de novo' pyrimidine nucleobase biosynthetic process//oxidation-reduction process//tRNA processing//regulation of transcription, DNA-templated//obsolete electron transport//riboflavin biosynthetic process//UMP biosynthetic process//metabolic process//DNA-templated transcription, initiation//DNA recombination//riboflavin metabolic process//pyrimidine nucleobase metabolic process GO:0000150//GO:0070569//GO:0016765//GO:0003700//GO:0016627//GO:0003919//GO:0051536//GO:0017150//GO:0016491//GO:0004158//GO:0003677//GO:0009055//GO:0016987//GO:0003676//GO:0050660 recombinase activity//uridylyltransferase activity//transferase activity, transferring alkyl or aryl (other than methyl) groups//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//FMN adenylyltransferase activity//iron-sulfur cluster binding//tRNA dihydrouridine synthase activity//oxidoreductase activity//dihydroorotate oxidase activity//DNA binding//electron carrier activity//sigma factor activity//nucleic acid binding//flavin adenine dinucleotide binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.35643 BP_3 225.00 13.93 1070 -- -- -- -- -- 642911838 XM_008202546.1 52 5.88934e-16 PREDICTED: Tribolium castaneum endophilin-A (LOC661913), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35644 BP_3 2045.35 10.69 9514 642930211 XP_008196303.1 2794 0.0e+00 PREDICTED: protein aubergine [Tribolium castaneum]>gi|642930213|ref|XP_008196304.1| PREDICTED: protein aubergine [Tribolium castaneum]>gi|270010977|gb|EFA07425.1| piwi [Tribolium castaneum] 820846169 XM_003692874.2 149 6.44118e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 1693 1.2e-186 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF02230//PF02171//PF04636//PF07859//PF09494//PF15384//PF01764//PF02170//PF02186 Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin)//alpha/beta hydrolase fold//Slx4 endonuclease//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//Lipase (class 3)//PAZ domain//TFIIE beta subunit core domain GO:0006260//GO:0006308//GO:0006367//GO:1901031//GO:0008152//GO:0006303//GO:0006281//GO:0006629 DNA replication//DNA catabolic process//transcription initiation from RNA polymerase II promoter//regulation of response to reactive oxygen species//metabolic process//double-strand break repair via nonhomologous end joining//DNA repair//lipid metabolic process GO:0003676//GO:0016787//GO:0005515//GO:0017108 nucleic acid binding//hydrolase activity//protein binding//5'-flap endonuclease activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.35649 BP_3 64.32 0.96 3509 91081301 XP_968960.1 3902 0.0e+00 PREDICTED: glycogen phosphorylase [Tribolium castaneum]>gi|270006093|gb|EFA02541.1| hypothetical protein TcasGA2_TC008246 [Tribolium castaneum] 817087305 XM_012410997.1 451 0 PREDICTED: Athalia rosae glycogen phosphorylase (LOC105692065), mRNA K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 P11216 3201 0.0e+00 Glycogen phosphorylase, brain form OS=Homo sapiens GN=PYGB PE=1 SV=5 PF00343 Carbohydrate phosphorylase GO:0005975 carbohydrate metabolic process GO:0030170//GO:0008184 pyridoxal phosphate binding//glycogen phosphorylase activity -- -- KOG2099 Glycogen phosphorylase Cluster-8309.35650 BP_3 10801.79 138.68 4046 642934871 XP_008197844.1 2971 0.0e+00 PREDICTED: ecdysone-inducible protein E75 isoform X2 [Tribolium castaneum] 642934870 XM_008199622.1 588 0 PREDICTED: Tribolium castaneum ecdysone-inducible protein E75 (LOC660005), transcript variant X2, mRNA K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1750 1.3e-193 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.35652 BP_3 260.34 4.36 3170 270016355 EFA12801.1 1835 3.4e-202 hypothetical protein TcasGA2_TC001864 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35653 BP_3 214.40 2.64 4213 91078690 XP_971137.1 2336 3.7e-260 PREDICTED: eukaryotic translation initiation factor 3 subunit L [Tribolium castaneum]>gi|270003761|gb|EFA00209.1| hypothetical protein TcasGA2_TC003034 [Tribolium castaneum] -- -- -- -- -- K15029 EIF3L translation initiation factor 3 subunit L http://www.genome.jp/dbget-bin/www_bget?ko:K15029 Q16FL6 1819 1.3e-201 Eukaryotic translation initiation factor 3 subunit L OS=Aedes aegypti GN=AAEL009617 PE=3 SV=1 PF10255//PF07668 RNA polymerase I-associated factor PAF67//M penetrans paralogue family 1 GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005737//GO:0005852//GO:0016020//GO:0005840 cytoplasm//eukaryotic translation initiation factor 3 complex//membrane//ribosome KOG4197 FOG: PPR repeat Cluster-8309.35654 BP_3 4532.00 34.69 6589 642919151 XP_008191758.1 6970 0.0e+00 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] 884968689 XM_013138180.1 39 6.27092e-08 PREDICTED: Esox lucius low-density lipoprotein receptor-related protein 1-like (LOC105017034), mRNA -- -- -- -- O88307 2465 2.6e-276 Sortilin-related receptor OS=Mus musculus GN=Sorl1 PE=1 SV=3 PF00057//PF05196//PF00041//PF01445 Low-density lipoprotein receptor domain class A//PTN/MK heparin-binding protein family, N-terminal domain//Fibronectin type III domain//Viral small hydrophobic protein GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083//GO:0005515 growth factor activity//protein binding GO:0016020 membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.35656 BP_3 715.00 7.52 4873 332376432 AEE63356.1 1763 1.2e-193 unknown [Dendroctonus ponderosae]>gi|478260884|gb|ENN80521.1| hypothetical protein YQE_03060, partial [Dendroctonus ponderosae] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q6GMK8 1320 1.1e-143 Mannose-1-phosphate guanyltransferase alpha-A OS=Danio rerio GN=gmppaa PE=2 SV=1 PF10584//PF00795//PF00483 Proteasome subunit A N-terminal signature//Carbon-nitrogen hydrolase//Nucleotidyl transferase GO:0009058//GO:0006807//GO:0006511 biosynthetic process//nitrogen compound metabolic process//ubiquitin-dependent protein catabolic process GO:0004175//GO:0016779//GO:0016810 endopeptidase activity//nucleotidyltransferase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0019773 proteasome core complex, alpha-subunit complex KOG1460 GDP-mannose pyrophosphorylase Cluster-8309.35657 BP_3 214.69 12.90 1094 91083531 XP_973193.1 847 4.3e-88 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q8K354 481 4.9e-47 Carbonyl reductase [NADPH] 3 OS=Mus musculus GN=Cbr3 PE=2 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.35660 BP_3 98.00 6.40 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35661 BP_3 17753.28 757.75 1421 642936715 XP_008198550.1 1108 3.1e-118 PREDICTED: 60S ribosomal protein L5 [Tribolium castaneum]>gi|270000965|gb|EEZ97412.1| hypothetical protein TcasGA2_TC011241 [Tribolium castaneum] 665810153 XM_008555260.1 161 2.01172e-76 PREDICTED: Microplitis demolitor 60S ribosomal protein L5 (LOC103575464), mRNA K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 O76190 994 2.1e-106 60S ribosomal protein L5 OS=Bombyx mori GN=RpL5 PE=2 SV=1 PF00861 Ribosomal L18p/L5e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0875 60S ribosomal protein L5 Cluster-8309.35662 BP_3 628.73 8.24 3970 91084587 XP_974100.1 2483 3.1e-277 PREDICTED: zinc finger FYVE domain-containing protein 9 [Tribolium castaneum]>gi|270008651|gb|EFA05099.1| hypothetical protein TcasGA2_TC015198 [Tribolium castaneum] -- -- -- -- -- K04679 MADHIP, SARA MAD, mothers against decapentaplegic interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K04679 O95405 1357 4.7e-148 Zinc finger FYVE domain-containing protein 9 OS=Homo sapiens GN=ZFYVE9 PE=1 SV=2 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1841 Smad anchor for receptor activation Cluster-8309.35665 BP_3 28.68 0.37 4072 751229541 XP_011168238.1 1136 5.0e-121 PREDICTED: REST corepressor isoform X3 [Solenopsis invicta] 817199620 XM_012420083.1 130 1.00098e-58 PREDICTED: Orussus abietinus uncharacterized LOC105697085 (LOC105697085), transcript variant X3, mRNA -- -- -- -- Q59E36 809 1.7e-84 REST corepressor OS=Drosophila melanogaster GN=CoRest PE=1 SV=2 PF00376 MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG1194 Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains Cluster-8309.35667 BP_3 1328.00 27.97 2580 91081423 XP_973326.1 1015 3.4e-107 PREDICTED: eukaryotic translation initiation factor 3 subunit K [Tribolium castaneum]>gi|270005163|gb|EFA01611.1| hypothetical protein TcasGA2_TC007178 [Tribolium castaneum] -- -- -- -- -- K15028 EIF3K translation initiation factor 3 subunit K http://www.genome.jp/dbget-bin/www_bget?ko:K15028 Q1HPS4 805 3.1e-84 Eukaryotic translation initiation factor 3 subunit K OS=Bombyx mori PE=2 SV=1 PF09421//PF00957//PF05739//PF03530 Frequency clock protein//Synaptobrevin//SNARE domain//Calcium-activated SK potassium channel GO:0006355//GO:0006813//GO:0007623//GO:0016192//GO:0006446 regulation of transcription, DNA-templated//potassium ion transport//circadian rhythm//vesicle-mediated transport//regulation of translational initiation GO:0016286//GO:0005515//GO:0003743//GO:0043022 small conductance calcium-activated potassium channel activity//protein binding//translation initiation factor activity//ribosome binding GO:0005852//GO:0005737//GO:0005840//GO:0005634//GO:0016021 eukaryotic translation initiation factor 3 complex//cytoplasm//ribosome//nucleus//integral component of membrane KOG3252 Uncharacterized conserved protein Cluster-8309.35668 BP_3 63.67 0.66 4927 478251222 ENN71696.1 1191 2.5e-127 hypothetical protein YQE_11619, partial [Dendroctonus ponderosae] 315115388 HQ424723.1 158 3.30184e-74 Euphydryas aurinia ribosomal protein S15 (RpS15) mRNA, complete cds K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 Q291K8 501 1.1e-48 Stress-activated map kinase-interacting protein 1 OS=Drosophila pseudoobscura pseudoobscura GN=Sin1 PE=3 SV=2 PF00654//PF04145//PF00203 Voltage gated chloride channel//Ctr copper transporter family//Ribosomal protein S19 GO:0042254//GO:0035434//GO:0006821//GO:0006825//GO:0006412//GO:0055085 ribosome biogenesis//copper ion transmembrane transport//chloride transport//copper ion transport//translation//transmembrane transport GO:0005375//GO:0003735//GO:0005247 copper ion transmembrane transporter activity//structural constituent of ribosome//voltage-gated chloride channel activity GO:0005840//GO:0016020//GO:0016021 ribosome//membrane//integral component of membrane KOG0898 40S ribosomal protein S15 Cluster-8309.35669 BP_3 5480.99 264.90 1289 264667397 ACY71284.1 327 1.0e-27 ribosomal protein L37 [Chrysomela tremula] 70909882 AM049128.1 111 1.13488e-48 Sphaerius sp. APV-2005 mRNA for ribosomal protein L37e (rpL37e gene) K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q962S7 298 9.6e-26 60S ribosomal protein L37 OS=Spodoptera frugiperda GN=RpL37 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3475 60S ribosomal protein L37 Cluster-8309.35670 BP_3 15.07 0.38 2205 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03286//PF02178 Pox virus Ag35 surface protein//AT hook motif -- -- GO:0003677 DNA binding GO:0019031 viral envelope -- -- Cluster-8309.35674 BP_3 18.96 0.85 1368 642937322 XP_008198787.1 315 2.6e-26 PREDICTED: protein lap4-like [Tribolium castaneum] -- -- -- -- -- K16175 SCRIB protein scribble http://www.genome.jp/dbget-bin/www_bget?ko:K16175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35675 BP_3 43.87 0.35 6305 332375504 AEE62893.1 1136 7.7e-121 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10410 DNALI dynein light intermediate chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10410 Q26630 486 7.4e-47 33 kDa inner dynein arm light chain, axonemal OS=Strongylocentrotus purpuratus PE=1 SV=1 PF02183//PF07850//PF15898//PF12474//PF04111//PF01166//PF16944 Homeobox associated leucine zipper//Renin receptor-like protein//cGMP-dependent protein kinase interacting domain//Polo kinase kinase//Autophagy protein Apg6//TSC-22/dip/bun family//Fungal potassium channel GO:0009069//GO:0006914//GO:0007165//GO:0006355//GO:0006813//GO:0071805//GO:0016310 serine family amino acid metabolic process//autophagy//signal transduction//regulation of transcription, DNA-templated//potassium ion transport//potassium ion transmembrane transport//phosphorylation GO:0015079//GO:0003700//GO:0004674//GO:0043565//GO:0019901//GO:0004872 potassium ion transmembrane transporter activity//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity//sequence-specific DNA binding//protein kinase binding//receptor activity GO:0016021//GO:0005887//GO:0005667 integral component of membrane//integral component of plasma membrane//transcription factor complex KOG4001 Axonemal dynein light chain Cluster-8309.35676 BP_3 2607.47 17.77 7365 332375504 AEE62893.1 1136 9.0e-121 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10410 DNALI dynein light intermediate chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10410 Q26630 486 8.7e-47 33 kDa inner dynein arm light chain, axonemal OS=Strongylocentrotus purpuratus PE=1 SV=1 PF12474//PF16944//PF04111//PF15898//PF00997//PF02183//PF07850//PF01166 Polo kinase kinase//Fungal potassium channel//Autophagy protein Apg6//cGMP-dependent protein kinase interacting domain//Kappa casein//Homeobox associated leucine zipper//Renin receptor-like protein//TSC-22/dip/bun family GO:0006813//GO:0071805//GO:0016310//GO:0006355//GO:0007165//GO:0009069//GO:0006914 potassium ion transport//potassium ion transmembrane transport//phosphorylation//regulation of transcription, DNA-templated//signal transduction//serine family amino acid metabolic process//autophagy GO:0004872//GO:0043565//GO:0019901//GO:0003700//GO:0004674//GO:0015079 receptor activity//sequence-specific DNA binding//protein kinase binding//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity//potassium ion transmembrane transporter activity GO:0005576//GO:0005667//GO:0016021//GO:0005887 extracellular region//transcription factor complex//integral component of membrane//integral component of plasma membrane KOG4001 Axonemal dynein light chain Cluster-8309.35677 BP_3 639.54 20.97 1762 332376075 AEE63178.1 1140 7.4e-122 unknown [Dendroctonus ponderosae] 820864294 XM_003698316.2 303 2.89555e-155 PREDICTED: Apis florea MOB kinase activator-like 1 (LOC100870844), transcript variant X2, mRNA K06685 MOB1, Mats MOB kinase activator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06685 Q95RA8 1073 1.8e-115 MOB kinase activator-like 1 OS=Drosophila melanogaster GN=mats PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.35678 BP_3 12.72 0.37 1931 478250085 ENN70591.1 962 3.5e-101 hypothetical protein YQE_12766, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 306 1.7e-26 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35679 BP_3 857.00 15.00 3046 -- -- -- -- -- 642919818 XM_008193860.1 102 2.74254e-43 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X7, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35680 BP_3 10448.04 674.81 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140//PF04625 Crustacean cuticle protein repeat//DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213//GO:0042302 structural constituent of chorion//structural constituent of cuticle GO:0005576//GO:0042600 extracellular region//chorion -- -- Cluster-8309.35681 BP_3 1998.00 89.48 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35682 BP_3 2748.00 85.16 1847 642934891 XP_971764.2 1071 7.8e-114 PREDICTED: retinol dehydrogenase 14 [Tribolium castaneum] -- -- -- -- -- K11162 RDH14 retinol dehydrogenase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11162 Q9ERI6 664 5.0e-68 Retinol dehydrogenase 14 OS=Mus musculus GN=Rdh14 PE=2 SV=1 PF02826//PF01370//PF03435//PF00106//PF01073 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008209//GO:0006694//GO:0055114//GO:0008207//GO:0008210//GO:0008152 androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//estrogen metabolic process//metabolic process GO:0016491//GO:0016616//GO:0051287//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- -- -- Cluster-8309.35683 BP_3 2574.30 59.62 2373 478252477 ENN72899.1 961 5.7e-101 hypothetical protein YQE_10469, partial [Dendroctonus ponderosae]>gi|546682597|gb|ERL92516.1| hypothetical protein D910_09829 [Dendroctonus ponderosae] 642923699 XM_008195626.1 122 1.62416e-54 PREDICTED: Tribolium castaneum uncharacterized LOC103313143 (LOC103313143), mRNA -- -- -- -- Q66IT9 149 3.3e-08 Immediate early response gene 5-like protein OS=Xenopus laevis GN=ier5l PE=2 SV=2 PF07557//PF09726 Shugoshin C terminus//Transmembrane protein GO:0045132 meiotic chromosome segregation -- -- GO:0016021//GO:0005634//GO:0000775 integral component of membrane//nucleus//chromosome, centromeric region -- -- Cluster-8309.35685 BP_3 17.26 0.59 1711 91080769 XP_967976.1 1402 3.0e-152 PREDICTED: 26S protease regulatory subunit 6B [Tribolium castaneum]>gi|270005883|gb|EFA02331.1| hypothetical protein TcasGA2_TC007999 [Tribolium castaneum] 817201582 XM_012421120.1 260 2.25051e-131 PREDICTED: Orussus abietinus 26S protease regulatory subunit 6B (LOC105697634), mRNA K03063 PSMC4, RPT3 26S proteasome regulatory subunit T3 http://www.genome.jp/dbget-bin/www_bget?ko:K03063 P46507 1319 5.2e-144 26S protease regulatory subunit 6B OS=Manduca sexta PE=2 SV=1 PF00004//PF00158//PF01057//PF07728//PF01695//PF00931//PF06414//PF02367//PF07724//PF06068//PF05496//PF00910//PF01637//PF07726//PF03266//PF00005 ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//NB-ARC domain//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//AAA domain (Cdc48 subfamily)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//RNA helicase//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//NTPase//ABC transporter GO:0002949//GO:0006310//GO:0030163//GO:0019079//GO:0006281//GO:0006355 tRNA threonylcarbamoyladenosine modification//DNA recombination//protein catabolic process//viral genome replication//DNA repair//regulation of transcription, DNA-templated GO:0003678//GO:0003723//GO:0043531//GO:0017111//GO:0009378//GO:0003724//GO:0005524//GO:0098519//GO:0008134//GO:0016301//GO:0016887 DNA helicase activity//RNA binding//ADP binding//nucleoside-triphosphatase activity//four-way junction helicase activity//RNA helicase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//kinase activity//ATPase activity GO:0005657//GO:0005667//GO:0009379//GO:0005737 replication fork//transcription factor complex//Holliday junction helicase complex//cytoplasm KOG0727 26S proteasome regulatory complex, ATPase RPT3 Cluster-8309.35686 BP_3 86.64 2.80 1785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35688 BP_3 821.00 11.16 3836 91088687 XP_974969.1 1899 1.6e-209 PREDICTED: COP9 signalosome complex subunit 4 [Tribolium castaneum]>gi|270011671|gb|EFA08119.1| hypothetical protein TcasGA2_TC005723 [Tribolium castaneum] 749787628 XM_011149029.1 221 2.44138e-109 PREDICTED: Harpegnathos saltator COP9 signalosome complex subunit 4 (LOC105187902), mRNA K12178 COPS4, CSN4 COP9 signalosome complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12178 Q6P0H6 1564 4.5e-172 COP9 signalosome complex subunit 4 OS=Danio rerio GN=cops4 PE=2 SV=1 PF13202//PF13176//PF02733//PF01399//PF00036//PF13181//PF02734//PF13499//PF13833 EF hand//Tetratricopeptide repeat//Dak1 domain//PCI domain//EF hand//Tetratricopeptide repeat//DAK2 domain//EF-hand domain pair//EF-hand domain pair GO:0046486//GO:0006071 glycerolipid metabolic process//glycerol metabolic process GO:0005515//GO:0004371//GO:0005509 protein binding//glycerone kinase activity//calcium ion binding -- -- KOG2426 Dihydroxyacetone kinase/glycerone kinase Cluster-8309.35689 BP_3 12095.92 2609.58 515 91083227 XP_973632.1 665 2.6e-67 PREDICTED: 40S ribosomal protein S18 [Tribolium castaneum]>gi|270007711|gb|EFA04159.1| hypothetical protein TcasGA2_TC014405 [Tribolium castaneum] 264667372 GU120422.1 217 5.17437e-108 Chrysomela tremulae ribosomal protein S18 (RpS18) mRNA, complete cds K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q962R1 644 2.9e-66 40S ribosomal protein S18 OS=Spodoptera frugiperda GN=RpS18 PE=2 SV=1 PF00416 Ribosomal protein S13/S18 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG3311 Ribosomal protein S18 Cluster-8309.35690 BP_3 13231.31 284.92 2530 642928339 XP_008195541.1 1614 1.2e-176 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog-like isoform X1 [Tribolium castaneum] 571531697 XM_006570187.1 76 6.45824e-29 PREDICTED: Apis mellifera synaptic vesicle membrane protein VAT-1 homolog-like (LOC409207), mRNA -- -- -- -- Q9HCJ6 992 6.3e-106 Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens GN=VAT1L PE=1 SV=2 PF08240//PF00107//PF00335//PF02862//PF10152//PF01118 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase//Tetraspanin family//DDHD domain//Predicted coiled-coil domain-containing protein (DUF2360)//Semialdehyde dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0046872//GO:0016620//GO:0051287 metal ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding GO:0016021//GO:0071203 integral component of membrane//WASH complex KOG1197 Predicted quinone oxidoreductase Cluster-8309.35691 BP_3 213.20 4.87 2402 642919825 XP_008192085.1 496 4.8e-47 PREDICTED: uncharacterized protein LOC103312661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35692 BP_3 15.55 0.36 2393 91085301 XP_968534.1 1697 2.6e-186 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum]>gi|270009220|gb|EFA05668.1| hypothetical protein TcasGA2_TC014946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 521 2.5e-51 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.35694 BP_3 1289.94 51.20 1506 189238336 XP_001806936.1 250 1.0e-18 PREDICTED: uncharacterized protein LOC100141997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35695 BP_3 6317.00 443.67 978 288869508 NP_001165861.1 584 1.2e-57 ribosomal protein S6 [Tribolium castaneum]>gi|270014845|gb|EFA11293.1| hypothetical protein TcasGA2_TC010830 [Tribolium castaneum] -- -- -- -- -- K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 Q95V32 503 1.2e-49 40S ribosomal protein S6 OS=Spodoptera frugiperda GN=RpS6 PE=2 SV=1 PF01092 Ribosomal protein S6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1646 40S ribosomal protein S6 Cluster-8309.35697 BP_3 108.70 8.85 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35698 BP_3 853.79 9.05 4838 270014789 EFA11237.1 2314 1.5e-257 hypothetical protein TcasGA2_TC010769 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHH9 1291 2.6e-140 Tetratricopeptide repeat protein 39B OS=Xenopus laevis GN=ttc39b PE=2 SV=1 PF13414//PF13174//PF06703//PF09110//PF04226//PF13181//PF00515 TPR repeat//Tetratricopeptide repeat//Microsomal signal peptidase 25 kDa subunit (SPC25)//HAND//Transglycosylase associated protein//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0043044//GO:0006465 ATP-dependent chromatin remodeling//signal peptide processing GO:0031491//GO:0005515//GO:0008233 nucleosome binding//protein binding//peptidase activity GO:0000785//GO:0016021//GO:0005787 chromatin//integral component of membrane//signal peptidase complex KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1 Cluster-8309.35700 BP_3 3929.00 703.08 561 765141696 XP_011482082.1 704 8.4e-72 PREDICTED: polyubiquitin-C [Oryzias latipes] 330805886 XM_003290860.1 206 7.38565e-102 Dictyostelium purpureum ubiquitin, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 P0CG67 699 1.3e-72 Polyubiquitin-B OS=Gorilla gorilla gorilla GN=UBB PE=3 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35701 BP_3 206.77 5.36 2152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35704 BP_3 287.76 3.01 4902 478255990 ENN76189.1 1139 2.7e-121 hypothetical protein YQE_07157, partial [Dendroctonus ponderosae] 755992161 XM_011314822.1 134 7.21202e-61 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 710 6.1e-73 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00549//PF00583//PF13508//PF08445//PF13673 CoA-ligase//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0003824//GO:0016747//GO:0008080 catalytic activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.35705 BP_3 1236.75 30.15 2269 91086399 XP_974859.1 2065 5.2e-229 PREDICTED: 26S protease regulatory subunit 4 [Tribolium castaneum]>gi|270010293|gb|EFA06741.1| hypothetical protein TcasGA2_TC009675 [Tribolium castaneum] 829812394 XM_012773957.1 384 0 PREDICTED: Microcebus murinus proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1), mRNA K03062 PSMC1, RPT2 26S proteasome regulatory subunit T2 http://www.genome.jp/dbget-bin/www_bget?ko:K03062 P48601 1995 2.8e-222 26S protease regulatory subunit 4 OS=Drosophila melanogaster GN=Rpt2 PE=1 SV=2 PF00931//PF00910//PF02367//PF02562//PF07726//PF00005//PF07724//PF00004//PF00158//PF06068//PF01057//PF05496//PF07728//PF01695 NB-ARC domain//RNA helicase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//ABC transporter//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006355//GO:0006281//GO:0019079//GO:0030163//GO:0006310//GO:0002949 regulation of transcription, DNA-templated//DNA repair//viral genome replication//protein catabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0016887//GO:0008134//GO:0005524//GO:0003724//GO:0009378//GO:0017111//GO:0043531//GO:0003723//GO:0003678 ATPase activity//transcription factor binding//ATP binding//RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//ADP binding//RNA binding//DNA helicase activity GO:0005737//GO:0009379//GO:0005667//GO:0005657 cytoplasm//Holliday junction helicase complex//transcription factor complex//replication fork KOG0726 26S proteasome regulatory complex, ATPase RPT2 Cluster-8309.35706 BP_3 44.58 2.65 1103 -- -- -- -- -- 642913456 XM_008202798.1 98 1.63089e-41 PREDICTED: Tribolium castaneum ankyrin repeat domain-containing protein 17 (LOC663344), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35707 BP_3 3637.31 68.69 2844 546677850 ERL88607.1 2041 4.0e-226 hypothetical protein D910_05992 [Dendroctonus ponderosae] -- -- -- -- -- K04727 PDCD8, AIF programmed cell death 8 (apoptosis-inducing factor) http://www.genome.jp/dbget-bin/www_bget?ko:K04727 Q9JM53 1454 1.9e-159 Apoptosis-inducing factor 1, mitochondrial OS=Rattus norvegicus GN=Aifm1 PE=1 SV=1 PF01593//PF14721//PF00070//PF07992//PF01266//PF11590 Flavin containing amine oxidoreductase//Apoptosis-inducing factor, mitochondrion-associated, C-term//Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//DNA polymerase catalytic subunit Pol GO:0006260//GO:0055114//GO:0051252 DNA replication//oxidation-reduction process//regulation of RNA metabolic process GO:0046983//GO:0016491//GO:0003887//GO:0004523 protein dimerization activity//oxidoreductase activity//DNA-directed DNA polymerase activity//RNA-DNA hybrid ribonuclease activity GO:0042575 DNA polymerase complex KOG1346 Programmed cell death 8 (apoptosis-inducing factor) Cluster-8309.3571 BP_3 3.00 0.72 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35711 BP_3 9.00 0.31 1696 642936715 XP_008198550.1 1103 1.4e-117 PREDICTED: 60S ribosomal protein L5 [Tribolium castaneum]>gi|270000965|gb|EEZ97412.1| hypothetical protein TcasGA2_TC011241 [Tribolium castaneum] 665810153 XM_008555260.1 159 3.11866e-75 PREDICTED: Microplitis demolitor 60S ribosomal protein L5 (LOC103575464), mRNA K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 O76190 989 9.4e-106 60S ribosomal protein L5 OS=Bombyx mori GN=RpL5 PE=2 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG0875 60S ribosomal protein L5 Cluster-8309.35712 BP_3 882.34 16.26 2907 189238197 XP_001807880.1 3338 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|642925484|ref|XP_008194570.1| PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|270008848|gb|EFA05296.1| hypothetical protein TcasGA2_TC015453 [Tribolium castaneum] 755988497 XM_011313566.1 299 8.05237e-153 PREDICTED: Fopius arisanus eukaryotic translation initiation factor 3 subunit C (LOC105271805), mRNA K03252 EIF3C translation initiation factor 3 subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K03252 Q17Q06 2672 1.1e-300 Eukaryotic translation initiation factor 3 subunit C OS=Aedes aegypti GN=eIF3-S8 PE=3 SV=1 PF01399//PF05470 PCI domain//Eukaryotic translation initiation factor 3 subunit 8 N-terminus GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743//GO:0031369//GO:0005515 translation initiation factor activity//translation initiation factor binding//protein binding GO:0005840//GO:0005852 ribosome//eukaryotic translation initiation factor 3 complex KOG1076 Translation initiation factor 3, subunit c (eIF-3c) Cluster-8309.35713 BP_3 68.52 1.16 3140 270010184 EFA06632.1 2456 3.3e-274 hypothetical protein TcasGA2_TC009552 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08622 Svf1-like GO:0006979 response to oxidative stress -- -- -- -- -- -- Cluster-8309.35714 BP_3 12.96 0.38 1946 270008143 EFA04591.1 349 4.3e-30 serpin peptidase inhibitor 28 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P48594 191 3.7e-13 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35716 BP_3 580.46 56.04 791 270006594 EFA03042.1 295 3.2e-24 hypothetical protein TcasGA2_TC010468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35718 BP_3 1161.74 5.96 9682 270010611 EFA07059.1 1520 3.5e-165 hypothetical protein TcasGA2_TC010036 [Tribolium castaneum] 189239538 XM_970519.2 321 1.5934e-164 PREDICTED: Tribolium castaneum ras-related protein Rab-23 (LOC664521), mRNA K06234 RAB23 Ras-related protein Rab-23 http://www.genome.jp/dbget-bin/www_bget?ko:K06234 Q9ULC3 565 7.9e-56 Ras-related protein Rab-23 OS=Homo sapiens GN=RAB23 PE=1 SV=1 PF04670//PF10662//PF00071//PF03193//PF00025//PF02421//PF01926//PF12106//PF08477//PF00735 Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ferrous iron transport protein B//50S ribosome-binding GTPase//Colicin C terminal ribonuclease domain//Ras of Complex, Roc, domain of DAPkinase//Septin GO:0006576//GO:0007264//GO:0015684//GO:0051252 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport//regulation of RNA metabolic process GO:0015093//GO:0005524//GO:0003924//GO:0004540//GO:0005525 ferrous iron transmembrane transporter activity//ATP binding//GTPase activity//ribonuclease activity//GTP binding GO:0016021 integral component of membrane KOG0079 GTP-binding protein H-ray, small G protein superfamily Cluster-8309.35722 BP_3 28.08 0.53 2837 270010429 EFA06877.1 958 1.5e-100 hypothetical protein TcasGA2_TC009822 [Tribolium castaneum] -- -- -- -- -- K13511 TAZ monolysocardiolipin acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13511 Q9V6G5 674 5.3e-69 Tafazzin homolog OS=Drosophila melanogaster GN=Taz PE=2 SV=2 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG2847 Phosphate acyltransferase Cluster-8309.35723 BP_3 7.33 0.39 1207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35725 BP_3 22.23 0.31 3791 642918236 XP_008191424.1 3015 0.0e+00 PREDICTED: uncharacterized protein LOC658718 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.25693e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00130//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.35726 BP_3 725.35 22.32 1858 332372941 AEE61612.1 1837 1.2e-202 unknown [Dendroctonus ponderosae] 642917730 XM_008193127.1 339 2.97123e-175 PREDICTED: Tribolium castaneum glutamine synthetase 2 cytoplasmic (LOC656087), transcript variant X4, mRNA K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 P20478 1509 5.2e-166 Glutamine synthetase 2 cytoplasmic OS=Drosophila melanogaster GN=Gs2 PE=2 SV=3 PF03951//PF01844//PF00120 Glutamine synthetase, beta-Grasp domain//HNH endonuclease//Glutamine synthetase, catalytic domain GO:0009252//GO:0006807//GO:0006542 peptidoglycan biosynthetic process//nitrogen compound metabolic process//glutamine biosynthetic process GO:0003676//GO:0004356//GO:0004519 nucleic acid binding//glutamate-ammonia ligase activity//endonuclease activity -- -- KOG0683 Glutamine synthetase Cluster-8309.35728 BP_3 1928.54 27.62 3657 642930669 XP_008199217.1 692 1.4e-69 PREDICTED: uncharacterized protein LOC657834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53814 363 7.9e-33 Smoothelin OS=Homo sapiens GN=SMTN PE=1 SV=7 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.35729 BP_3 4294.85 11.47 18338 91087317 XP_975584.1 22328 0.0e+00 PREDICTED: dynein heavy chain, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270010987|gb|EFA07435.1| dynein heavy chain [Tribolium castaneum] 642929800 XM_970491.2 4295 0 PREDICTED: Tribolium castaneum dynein heavy chain (LOC664489), transcript variant X1, mRNA K10413 DYNC1H dynein heavy chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10413 P37276 19870 0.0e+00 Dynein heavy chain, cytoplasmic OS=Drosophila melanogaster GN=Dhc64C PE=2 SV=2 PF02932//PF03767//PF00437//PF00004//PF03028//PF12106//PF01695//PF07728//PF02477//PF01580//PF00910//PF00005 Neurotransmitter-gated ion-channel transmembrane region//HAD superfamily, subfamily IIIB (Acid phosphatase)//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor//Colicin C terminal ribonuclease domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Nucleocapsid N protein//FtsK/SpoIIIE family//RNA helicase//ABC transporter GO:0006811//GO:0006771//GO:0051252//GO:0007017//GO:0006810//GO:0006200//GO:0019497//GO:0007018 ion transport//riboflavin metabolic process//regulation of RNA metabolic process//microtubule-based process//transport//obsolete ATP catabolic process//hexachlorocyclohexane metabolic process//microtubule-based movement GO:0003724//GO:0003777//GO:0003723//GO:0003677//GO:0000166//GO:0003993//GO:0016887//GO:0004540//GO:0005524 RNA helicase activity//microtubule motor activity//RNA binding//DNA binding//nucleotide binding//acid phosphatase activity//ATPase activity//ribonuclease activity//ATP binding GO:0016020//GO:0005874//GO:0030286//GO:0019013 membrane//microtubule//dynein complex//viral nucleocapsid KOG3595 Dyneins, heavy chain Cluster-8309.3573 BP_3 4.00 0.59 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35730 BP_3 117.30 0.82 7225 390198530 AFL70632.1 2550 9.6e-285 putative hypoxia-inducible factor 1 beta [Callosobruchus maculatus] 820805517 KP147913.1 433 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1719 9.0e-190 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF00989//PF05191//PF00010//PF08447 PAS fold//Adenylate kinase, active site lid//Helix-loop-helix DNA-binding domain//PAS fold GO:0006144//GO:0046034//GO:0006355 purine nucleobase metabolic process//ATP metabolic process//regulation of transcription, DNA-templated GO:0046983//GO:0004017//GO:0005515 protein dimerization activity//adenylate kinase activity//protein binding -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.35731 BP_3 72.00 8.96 679 570341948 AHE77372.1 515 8.4e-50 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 231 3.0e-18 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF01873 Domain found in IF2B/IF5 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.35734 BP_3 187.00 74.30 412 91083339 XP_974988.1 344 3.4e-30 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [Tribolium castaneum]>gi|270008152|gb|EFA04600.1| hypothetical protein TcasGA2_TC013353 [Tribolium castaneum] -- -- -- -- -- K03946 NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03946 P0CB79 306 3.6e-27 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Pongo abelii GN=NDUFA2 PE=3 SV=1 PF02605 Photosystem I reaction centre subunit XI GO:0015979 photosynthesis -- -- GO:0009522//GO:0009538 photosystem I//photosystem I reaction center KOG3446 NADH:ubiquinone oxidoreductase NDUFA2/B8 subunit Cluster-8309.35735 BP_3 1490.07 5.91 12439 642937614 XP_008199122.1 15392 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 816 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 O95714 5622 0.0e+00 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2 PF02898//PF07236//PF00569//PF06701 Nitric oxide synthase, oxygenase domain//Phytoreovirus S7 protein//Zinc finger, ZZ type//Mib_herc2 GO:0006809//GO:0016567//GO:0055114 nitric oxide biosynthetic process//protein ubiquitination//oxidation-reduction process GO:0004842//GO:0004517//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//nitric-oxide synthase activity//metal ion binding//zinc ion binding GO:0019012 virion KOG1426 FOG: RCC1 domain Cluster-8309.35736 BP_3 519.00 84.42 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF08119 Arthropod defensin//Scorpion acidic alpha-KTx toxin family GO:0006810//GO:0006952//GO:0009405 transport//defense response//pathogenesis GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.35737 BP_3 674.00 12.87 2816 642937614 XP_008199122.1 3236 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 600 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 Q9VR91 2613 7.6e-294 Probable E3 ubiquitin-protein ligase HERC2 OS=Drosophila melanogaster GN=HERC2 PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.35738 BP_3 55.03 1.15 2601 478253032 ENN73412.1 234 1.2e-16 hypothetical protein YQE_09974, partial [Dendroctonus ponderosae] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q965X6 208 5.3e-15 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis elegans GN=siah-1 PE=1 SV=3 PF03145//PF14634//PF00097//PF02176//PF00942//PF15965//PF05195 Seven in absentia protein family//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//TRAF-type zinc finger//Cellulose binding domain//TRAF-like zinc-finger//Aminopeptidase P, N-terminal domain GO:0007275//GO:0006511//GO:0005975 multicellular organismal development//ubiquitin-dependent protein catabolic process//carbohydrate metabolic process GO:0030248//GO:0030145//GO:0005515//GO:0008270//GO:0004177//GO:0046872 cellulose binding//manganese ion binding//protein binding//zinc ion binding//aminopeptidase activity//metal ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.35739 BP_3 17.93 1.66 812 264667343 ACY71257.1 443 2.3e-41 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 315 6.4e-28 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF03868 Ribosomal protein L6, N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1694 60s ribosomal protein L6 Cluster-8309.35740 BP_3 60.25 0.89 3556 91091500 XP_968802.1 752 1.5e-76 PREDICTED: GTP-binding protein SAR1b [Tribolium castaneum]>gi|270001011|gb|EEZ97458.1| hypothetical protein TcasGA2_TC011289 [Tribolium castaneum] 676480291 XM_009063766.1 50 2.58685e-14 Lottia gigantea hypothetical protein mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q5HZY2 571 5.8e-57 GTP-binding protein SAR1b OS=Rattus norvegicus GN=Sar1b PE=2 SV=1 PF00071//PF04670//PF05493//PF00503//PF06858//PF00025//PF01926//PF08477 Ras family//Gtr1/RagA G protein conserved region//ATP synthase subunit H//G-protein alpha subunit//Nucleolar GTP-binding protein 1 (NOG1)//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0015991//GO:0007186//GO:0015992//GO:0007165//GO:0006886//GO:0016192 small GTPase mediated signal transduction//ATP hydrolysis coupled proton transport//G-protein coupled receptor signaling pathway//proton transport//signal transduction//intracellular protein transport//vesicle-mediated transport GO:0004871//GO:0005525//GO:0015078//GO:0019001//GO:0031683//GO:0003924 signal transducer activity//GTP binding//hydrogen ion transmembrane transporter activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0033179//GO:0005783//GO:0005794 proton-transporting V-type ATPase, V0 domain//endoplasmic reticulum//Golgi apparatus KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.35741 BP_3 5.85 0.35 1099 195053558 XP_001993693.1 204 1.6e-13 GH21130 [Drosophila grimshawi]>gi|193895563|gb|EDV94429.1| GH21130 [Drosophila grimshawi] 676480291 XM_009063766.1 36 4.74687e-07 Lottia gigantea hypothetical protein mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q5PYH3 161 6.3e-10 GTP-binding protein SAR1b OS=Sus scrofa GN=SAR1B PE=2 SV=1 -- -- GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005525 GTP binding GO:0005783//GO:0005794 endoplasmic reticulum//Golgi apparatus KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.35743 BP_3 10.00 1.51 610 559163445 AHB11276.1 389 3.1e-35 attacin-like immune protein [Diabrotica virgifera virgifera] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.35745 BP_3 44.58 3.99 830 91083431 XP_969550.1 269 3.5e-21 PREDICTED: membrane magnesium transporter 1 [Tribolium castaneum]>gi|270007793|gb|EFA04241.1| hypothetical protein TcasGA2_TC014495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32LC4 171 3.3e-11 Membrane magnesium transporter 1 OS=Bos taurus GN=MMGT1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35748 BP_3 151.99 5.81 1553 642918856 XP_008191616.1 670 2.1e-67 PREDICTED: pericentriolar material 1 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K16537 PCM1 pericentriolar material 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K16537 Q9PVV4 186 1.1e-12 Pericentriolar material 1 protein OS=Xenopus laevis GN=pcm1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3575 BP_3 30.57 0.66 2512 642913905 XP_008201208.1 736 7.4e-75 PREDICTED: putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X1 [Tribolium castaneum]>gi|270001644|gb|EEZ98091.1| hypothetical protein TcasGA2_TC000504 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35750 BP_3 83.80 0.68 6207 546675274 ERL86510.1 2651 1.6e-296 hypothetical protein D910_03914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR5 714 2.7e-73 GTPase-activating protein and VPS9 domain-containing protein 1 OS=Mus musculus GN=Gapvd1 PE=1 SV=2 PF02881//PF00616 SRP54-type protein, helical bundle domain//GTPase-activator protein for Ras-like GTPase GO:0043087//GO:0006614 regulation of GTPase activity//SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.35751 BP_3 49.78 1.01 2668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03896 Translocon-associated protein (TRAP), alpha subunit -- -- -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.35755 BP_3 243.32 38.92 593 91080463 XP_970045.1 406 3.2e-37 PREDICTED: NADH dehydrogenase [ubiquinone] 1 subunit C2 [Tribolium castaneum]>gi|270006395|gb|EFA02843.1| NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 [Tribolium castaneum] -- -- -- -- -- K03968 NDUFC2 NADH dehydrogenase (ubiquinone) 1 subunit C2 http://www.genome.jp/dbget-bin/www_bget?ko:K03968 -- -- -- -- PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006814//GO:0022900//GO:0006744//GO:0015992//GO:0006120 sodium ion transport//electron transport chain//ubiquinone biosynthetic process//proton transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016020//GO:0005739//GO:0005743 membrane//mitochondrion//mitochondrial inner membrane -- -- Cluster-8309.35756 BP_3 941.22 21.37 2415 91093505 XP_969151.1 2479 5.5e-277 PREDICTED: NADP-dependent malic enzyme [Tribolium castaneum]>gi|270002678|gb|EEZ99125.1| hypothetical protein TcasGA2_TC005232 [Tribolium castaneum] 194765020 XM_001964590.1 291 1.86973e-148 Drosophila ananassae GF23280 (Dana\GF23280), mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1667 3.2e-184 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF03949//PF00390 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0055114//GO:0006108//GO:0015976//GO:0006099//GO:0006090 oxidation-reduction process//malate metabolic process//carbon utilization//tricarboxylic acid cycle//pyruvate metabolic process GO:0051287//GO:0046872//GO:0004471 NAD binding//metal ion binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.35757 BP_3 393.77 3.38 5909 642919356 XP_008191837.1 2644 9.9e-296 PREDICTED: kinesin-like protein costa isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16844 1130 1.5e-121 Kinesin-like protein costa OS=Drosophila melanogaster GN=cos PE=1 SV=2 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0003777//GO:0005524//GO:0008017 microtubule motor activity//ATP binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG4280 Kinesin-like protein Cluster-8309.35758 BP_3 88.76 0.70 6397 642912785 XP_008201251.1 1526 4.7e-166 PREDICTED: uncharacterized protein LOC663557 isoform X1 [Tribolium castaneum] 795034384 XM_012009201.1 239 4.02742e-119 PREDICTED: Vollenhovia emeryi protein FAM46C (LOC105560258), transcript variant X3, mRNA -- -- -- -- Q7ZUP1 787 9.4e-82 Protein FAM46C OS=Danio rerio GN=fam46c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3852 Uncharacterized conserved protein Cluster-8309.35760 BP_3 86.69 1.54 3009 332374224 AEE62253.1 1544 1.8e-168 unknown [Dendroctonus ponderosae] 662188737 XM_008489835.1 98 4.53283e-41 PREDICTED: Diaphorina citri elongation factor Tu, mitochondrial (LOC103524802), mRNA K02358 tuf, TUFM elongation factor Tu http://www.genome.jp/dbget-bin/www_bget?ko:K02358 P49411 1108 2.7e-119 Elongation factor Tu, mitochondrial OS=Homo sapiens GN=TUFM PE=1 SV=2 PF00231//PF02602//PF00894//PF05165//PF03144//PF01926 ATP synthase//Uroporphyrinogen-III synthase HemD//Luteovirus coat protein//GTP cyclohydrolase III//Elongation factor Tu domain 2//50S ribosome-binding GTPase GO:0015992//GO:0009058//GO:0006807//GO:0006783//GO:0015986//GO:0033014//GO:0006119//GO:0015994 proton transport//biosynthetic process//nitrogen compound metabolic process//heme biosynthetic process//ATP synthesis coupled proton transport//tetrapyrrole biosynthetic process//oxidative phosphorylation//chlorophyll metabolic process GO:0046933//GO:0004852//GO:0046961//GO:0005198//GO:0003933//GO:0005525 proton-transporting ATP synthase activity, rotational mechanism//uroporphyrinogen-III synthase activity//proton-transporting ATPase activity, rotational mechanism//structural molecule activity//GTP cyclohydrolase activity//GTP binding GO:0045259//GO:0019028//GO:0045261 proton-transporting ATP synthase complex//viral capsid//proton-transporting ATP synthase complex, catalytic core F(1) KOG0460 Mitochondrial translation elongation factor Tu Cluster-8309.35762 BP_3 351.79 2.47 7148 546683575 ERL93373.1 567 8.3e-55 hypothetical protein D910_10665 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35764 BP_3 14.83 0.49 1739 264667395 ACY71283.1 883 4.6e-92 ribosomal protein S4 [Chrysomela tremula] 264667394 GU120433.1 137 5.43e-63 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 839 2.4e-88 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.35765 BP_3 141.55 2.06 3597 -- -- -- -- -- 642921886 XM_970820.3 81 1.53107e-31 PREDICTED: Tribolium castaneum Y-box factor homolog (LOC656063), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.35767 BP_3 89.22 3.40 1555 642912944 XP_008201318.1 854 9.5e-89 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 539 1.3e-53 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35769 BP_3 156.54 2.13 3834 546674788 ERL86084.1 2900 0.0e+00 hypothetical protein D910_03498, partial [Dendroctonus ponderosae] 573905099 XM_006640208.1 158 2.56397e-74 PREDICTED: Lepisosteus oculatus ubiquitin-protein ligase E3B-like (LOC102687052), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q7Z3V4 2102 1.9e-234 Ubiquitin-protein ligase E3B OS=Homo sapiens GN=UBE3B PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0942 E3 ubiquitin protein ligase Cluster-8309.35770 BP_3 68.14 0.86 4092 642935654 XP_008198101.1 3404 0.0e+00 PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935656|ref|XP_008198102.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935658|ref|XP_008198103.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum] 817215019 XM_012428261.1 140 2.77716e-64 PREDICTED: Orussus abietinus uncharacterized LOC105701487 (LOC105701487), mRNA K07817 PTPRN receptor-type tyrosine-protein phosphatase N http://www.genome.jp/dbget-bin/www_bget?ko:K07817 O02695 1329 8.6e-145 Receptor-type tyrosine-protein phosphatase N2 OS=Macaca nemestrina GN=PTPRN2 PE=2 SV=1 PF10590//PF00102//PF00782 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0055114//GO:0006570//GO:0006470 oxidation-reduction process//tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0016638//GO:0008138 protein tyrosine phosphatase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//protein tyrosine/serine/threonine phosphatase activity -- -- KOG0793 Protein tyrosine phosphatase Cluster-8309.35771 BP_3 2974.50 63.40 2553 478254028 ENN74320.1 1365 8.7e-148 hypothetical protein YQE_09291, partial [Dendroctonus ponderosae] -- -- -- -- -- K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 Q9D2A5 304 3.8e-26 Cyclic AMP-responsive element-binding protein 3-like protein 4 OS=Mus musculus GN=Creb3l4 PE=1 SV=1 PF04281//PF03131//PF07716//PF00170 Mitochondrial import receptor subunit Tom22//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006886//GO:0006355 intracellular protein transport//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005741 transcription factor complex//nucleus//mitochondrial outer membrane KOG0709 CREB/ATF family transcription factor Cluster-8309.35775 BP_3 87.30 1.07 4210 642931762 XP_008196718.1 2579 2.4e-288 PREDICTED: exocyst complex component 7 [Tribolium castaneum]>gi|270011742|gb|EFA08190.1| hypothetical protein TcasGA2_TC005817 [Tribolium castaneum] -- -- -- -- -- K07195 EXOC7, EXO70 exocyst complex component 7 http://www.genome.jp/dbget-bin/www_bget?ko:K07195 Q9VSJ8 1244 6.3e-135 Exocyst complex component 7 OS=Drosophila melanogaster GN=exo70 PE=1 SV=2 PF02214//PF03081//PF10392 BTB/POZ domain//Exo70 exocyst complex subunit//Golgi transport complex subunit 5 GO:0006887//GO:0006891//GO:0051260 exocytosis//intra-Golgi vesicle-mediated transport//protein homooligomerization -- -- GO:0000145//GO:0017119 exocyst//Golgi transport complex KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes Cluster-8309.35776 BP_3 114.49 0.75 7615 642924436 XP_008194297.1 1103 6.2e-117 PREDICTED: PDZ and LIM domain protein Zasp [Tribolium castaneum] 332376113 BT128237.1 195 1.38226e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 954 4.9e-101 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF05493//PF15247//PF13180//PF01371//PF00412//PF08782//PF00595 ATP synthase subunit H//Histone RNA hairpin-binding protein RNA-binding domain//PDZ domain//Trp repressor protein//LIM domain//c-SKI Smad4 binding domain//PDZ domain (Also known as DHR or GLGF) GO:0015991//GO:0006355//GO:0015992 ATP hydrolysis coupled proton transport//regulation of transcription, DNA-templated//proton transport GO:0003723//GO:0005515//GO:0008270//GO:0015078//GO:0003700//GO:0046332 RNA binding//protein binding//zinc ion binding//hydrogen ion transmembrane transporter activity//transcription factor activity, sequence-specific DNA binding//SMAD binding GO:0005667//GO:0005622//GO:0033179 transcription factor complex//intracellular//proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35778 BP_3 71.00 3.34 1315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35779 BP_3 92.87 2.72 1939 270006792 EFA03240.1 481 2.1e-45 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZA47 308 1.0e-26 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35780 BP_3 3051.47 66.97 2488 332375863 AEE63072.1 1058 3.4e-112 unknown [Dendroctonus ponderosae]>gi|478250905|gb|ENN71391.1| hypothetical protein YQE_11938, partial [Dendroctonus ponderosae]>gi|546671259|gb|ERL83646.1| hypothetical protein D910_00798 [Dendroctonus ponderosae]>gi|546678254|gb|ERL88926.1| hypothetical protein D910_06304 [Dendroctonus ponderosae] 755932870 XM_011316165.1 162 9.89931e-77 PREDICTED: Fopius arisanus ras-like GTP-binding protein Rho1 (LOC105273622), transcript variant X9, mRNA K04513 RHOA Ras homolog gene family, member A http://www.genome.jp/dbget-bin/www_bget?ko:K04513 P48148 946 1.3e-100 Ras-like GTP-binding protein Rho1 OS=Drosophila melanogaster GN=Rho1 PE=1 SV=1 PF08477//PF07244//PF04670//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Surface antigen variable number repeat//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0019867 outer membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.35781 BP_3 3813.00 62.46 3234 761896179 AJP75147.1 3356 0.0e+00 pyrroline-5-carboxylate synthetase [Leptinotarsa decemlineata] 642912198 XM_008202627.1 493 0 PREDICTED: Tribolium castaneum delta-1-pyrroline-5-carboxylate synthase (LOC658917), mRNA K12657 ALDH18A1, P5CS delta-1-pyrroline-5-carboxylate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K12657 Q9Z110 2171 1.6e-242 Delta-1-pyrroline-5-carboxylate synthase OS=Mus musculus GN=Aldh18a1 PE=1 SV=2 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG4165 Gamma-glutamyl phosphate reductase Cluster-8309.35782 BP_3 1911.00 23.95 4138 752869486 XP_011251858.1 1705 5.3e-187 PREDICTED: WD repeat-containing protein 47 isoform X2 [Camponotus floridanus] 766926462 XM_011496875.1 240 7.22446e-120 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- Q8CGF6 1098 5.3e-118 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.35783 BP_3 514.11 5.25 5015 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF03144//PF00983//PF01926 Elongation factor G, domain IV//Elongation factor Tu domain 2//Tymovirus coat protein//50S ribosome-binding GTPase -- -- GO:0005198//GO:0005525 structural molecule activity//GTP binding GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.35785 BP_3 4145.56 1048.84 482 91093173 XP_967937.1 413 4.0e-38 PREDICTED: 40S ribosomal protein S21 [Tribolium castaneum]>gi|270012942|gb|EFA09390.1| hypothetical protein TcasGA2_TC004308 [Tribolium castaneum] 645004566 XM_001604620.3 87 8.92681e-36 PREDICTED: Nasonia vitripennis 40S ribosomal protein S21 (LOC100114107), mRNA K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q4GXP2 405 1.4e-38 40S ribosomal protein S21 OS=Biphyllus lunatus GN=RpS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3486 40S ribosomal protein S21 Cluster-8309.35786 BP_3 7.27 0.55 933 264667375 ACY71273.1 498 1.1e-47 ribosomal protein S16 [Chrysomela tremula] -- -- -- -- -- K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 P62251 417 1.1e-39 40S ribosomal protein S16 OS=Aedes aegypti GN=RpS16 PE=2 SV=1 PF00380 Ribosomal protein S9/S16 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-8309.35787 BP_3 1269.00 62.78 1266 546674191 ERL85631.1 1076 1.4e-114 hypothetical protein D910_03049 [Dendroctonus ponderosae] 306847626 HM210791.1 72 5.33199e-27 Plutella xylostella Rieske iron-sulfur protein gene, complete cds K00411 UQCRFS1, RIP1, petA ubiquinol-cytochrome c reductase iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00411 Q69BJ9 794 2.9e-83 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Aotus azarae GN=UQCRFS1 PE=3 SV=1 PF02921//PF09165//PF00355 Ubiquinol cytochrome reductase transmembrane region//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//Rieske [2Fe-2S] domain GO:0015992//GO:0006119//GO:0055114//GO:0006118 proton transport//oxidative phosphorylation//oxidation-reduction process//obsolete electron transport GO:0016491//GO:0008121//GO:0051537 oxidoreductase activity//ubiquinol-cytochrome-c reductase activity//2 iron, 2 sulfur cluster binding -- -- KOG1671 Ubiquinol cytochrome c reductase, subunit RIP1 Cluster-8309.35788 BP_3 629.00 11.46 2937 189236489 XP_975064.2 1412 3.5e-153 PREDICTED: putative neutral sphingomyelinase [Tribolium castaneum]>gi|270005347|gb|EFA01795.1| hypothetical protein TcasGA2_TC007396 [Tribolium castaneum] -- -- -- -- -- K12351 SMPD2 sphingomyelin phosphodiesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12351 Q9VZS6 737 2.7e-76 Putative neutral sphingomyelinase OS=Drosophila melanogaster GN=CG12034 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3873 Sphingomyelinase family protein Cluster-8309.35789 BP_3 41.65 0.70 3151 642936524 XP_008198472.1 3435 0.0e+00 PREDICTED: transmembrane GTPase Marf [Tribolium castaneum]>gi|642936526|ref|XP_970147.2| PREDICTED: transmembrane GTPase Marf [Tribolium castaneum] 462318797 APGK01044284.1 207 1.21302e-101 Dendroctonus ponderosae Seq01044294, whole genome shotgun sequence K06030 MFN mitofusin http://www.genome.jp/dbget-bin/www_bget?ko:K06030 Q7YU24 2272 3.0e-254 Transmembrane GTPase Marf OS=Drosophila melanogaster GN=Marf PE=1 SV=1 PF11734//PF04799//PF01926 TilS substrate C-terminal domain//fzo-like conserved region//50S ribosome-binding GTPase GO:0008033//GO:0008053 tRNA processing//mitochondrial fusion GO:0016879//GO:0003924//GO:0005524//GO:0005525//GO:0000166 ligase activity, forming carbon-nitrogen bonds//GTPase activity//ATP binding//GTP binding//nucleotide binding GO:0016021//GO:0005737//GO:0005741 integral component of membrane//cytoplasm//mitochondrial outer membrane KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis Cluster-8309.35790 BP_3 314.68 3.44 4706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17053//PF03854 Genetic interactor of prohibitin 5//P-11 zinc finger GO:0000002 mitochondrial genome maintenance GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.35791 BP_3 423.02 18.01 1424 755948956 XP_011300956.1 1243 6.8e-134 PREDICTED: 40S ribosomal protein S4 [Fopius arisanus] 264667394 GU120433.1 359 0 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q56FH2 1208 3.2e-131 40S ribosomal protein S4 OS=Lysiphlebus testaceipes GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.35792 BP_3 184.00 22.27 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35793 BP_3 155.45 3.70 2316 282848147 NP_001164292.1 1039 5.0e-110 kayak isoform A [Tribolium castaneum]>gi|270014251|gb|EFA10699.1| kayak [Tribolium castaneum] -- -- -- -- -- K09031 FOSLN fos-like antigen, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09031 B4K617 198 6.8e-14 Transcription factor kayak OS=Drosophila mojavensis GN=kay PE=3 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.35795 BP_3 32.34 0.32 5170 189233702 XP_966993.2 1470 1.2e-159 PREDICTED: fibulin-2-like [Tribolium castaneum] -- -- -- -- -- K17307 FBLN1_2 fibulin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17307 P23142 415 1.0e-38 Fibulin-1 OS=Homo sapiens GN=FBLN1 PE=1 SV=4 PF00008//PF04947//PF07645//PF00906//PF04814 EGF-like domain//Poxvirus Late Transcription Factor VLTF3 like//Calcium-binding EGF domain//Hepatitis core antigen//Hepatocyte nuclear factor 1 (HNF-1), N terminus GO:0009405//GO:0045893//GO:0046782 pathogenesis//positive regulation of transcription, DNA-templated//regulation of viral transcription GO:0005509//GO:0005198//GO:0005515 calcium ion binding//structural molecule activity//protein binding GO:0005634 nucleus KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.35796 BP_3 2074.29 45.42 2493 91086497 XP_971040.1 1299 3.8e-140 PREDICTED: trimeric intracellular cation channel type B [Tribolium castaneum]>gi|642928310|ref|XP_008195528.1| PREDICTED: trimeric intracellular cation channel type B [Tribolium castaneum]>gi|642928313|ref|XP_008195530.1| PREDICTED: trimeric intracellular cation channel type B [Tribolium castaneum]>gi|270009804|gb|EFA06252.1| hypothetical protein TcasGA2_TC009110 [Tribolium castaneum] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8IVF4 580 3.7e-58 Dynein heavy chain 10, axonemal OS=Homo sapiens GN=DNAH10 PE=1 SV=4 PF05197//PF03028 TRIC channel//Dynein heavy chain and region D6 of dynein motor GO:0006812//GO:0007017//GO:0015672//GO:0007018 cation transport//microtubule-based process//monovalent inorganic cation transport//microtubule-based movement GO:0003777//GO:0005261 microtubule motor activity//cation channel activity GO:0016020//GO:0005874//GO:0030286 membrane//microtubule//dynein complex KOG3944 Uncharacterized conserved protein Cluster-8309.35797 BP_3 95.31 2.16 2421 167234457 NP_001107844.1 1519 1.1e-165 eukaryotic translation initiation factor 5 [Tribolium castaneum]>gi|642919625|ref|XP_008191995.1| PREDICTED: eukaryotic translation initiation factor 5 isoform X1 [Tribolium castaneum]>gi|270005452|gb|EFA01900.1| hypothetical protein TcasGA2_TC007510 [Tribolium castaneum] 167234456 NM_001114372.1 159 4.4799e-75 Tribolium castaneum eukaryotic translation initiation factor 5 (Eif5), mRNA K03262 EIF5 translation initiation factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03262 Q9VXK6 1299 1.5e-141 Eukaryotic translation initiation factor 5 OS=Drosophila melanogaster GN=eIF5 PE=1 SV=1 PF02020//PF14489//PF01873 eIF4-gamma/eIF5/eIF2-epsilon//QueF-like protein//Domain found in IF2B/IF5 GO:0008616//GO:0006446//GO:0016070//GO:0006413 queuosine biosynthetic process//regulation of translational initiation//RNA metabolic process//translational initiation GO:0003743//GO:0005515//GO:0033739 translation initiation factor activity//protein binding//preQ1 synthase activity GO:0005840 ribosome KOG2767 Translation initiation factor 5 (eIF-5) Cluster-8309.35798 BP_3 109.75 0.70 7819 642923476 XP_008193526.1 2358 1.9e-262 PREDICTED: nuclear pore complex protein Nup214 [Tribolium castaneum] -- -- -- -- -- K14863 YTM1, WDR12 ribosome biogenesis protein YTM1 http://www.genome.jp/dbget-bin/www_bget?ko:K14863 Q9W1X4 802 2.1e-83 Nuclear pore complex protein Nup214 OS=Drosophila melanogaster GN=Nup214 PE=1 SV=2 PF00400//PF08024 WD domain, G-beta repeat//Ant antimicrobial peptide GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515 protein binding GO:0005576 extracellular region KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats) Cluster-8309.35799 BP_3 5.00 0.66 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.358 BP_3 3.00 0.38 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35800 BP_3 10147.06 487.98 1294 264667419 ACY71295.1 992 7.9e-105 ribosomal protein L19 [Chrysomela tremula] 601036659 KJ028107.1 194 8.26477e-95 Diachasmimorpha longicaudata ribosomal protein L19 (rpl19) mRNA, complete cds K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 P36241 869 5.9e-92 60S ribosomal protein L19 OS=Drosophila melanogaster GN=RpL19 PE=1 SV=2 PF01280 Ribosomal protein L19e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1696 60s ribosomal protein L19 Cluster-8309.35801 BP_3 462.66 8.56 2896 795011741 XP_011874268.1 607 7.7e-60 PREDICTED: uncharacterized protein LOC105565573 [Vollenhovia emeryi] -- -- -- -- -- K15448 TRM112, TRMT112 multifunctional methyltransferase subunit TRM112 http://www.genome.jp/dbget-bin/www_bget?ko:K15448 Q9DCG9 366 2.8e-33 Multifunctional methyltransferase subunit TRM112-like protein OS=Mus musculus GN=Trmt112 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1088 Uncharacterized conserved protein Cluster-8309.35802 BP_3 905.87 39.29 1403 642920676 XP_008192517.1 670 1.9e-67 PREDICTED: troponin I isoform X10 [Tribolium castaneum] 332376704 BT128535.1 225 5.25395e-112 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 555 1.7e-55 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF01496//PF00992 V-type ATPase 116kDa subunit family//Troponin GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0005861//GO:0033179 troponin complex//proton-transporting V-type ATPase, V0 domain KOG3977 Troponin I Cluster-8309.35804 BP_3 488.70 4.03 6135 91090153 XP_972190.1 8471 0.0e+00 PREDICTED: CAD protein [Tribolium castaneum]>gi|270013749|gb|EFA10197.1| hypothetical protein TcasGA2_TC012392 [Tribolium castaneum] 218526269 EU860157.1 823 0 Strangalia bicolor carbamoyl-phosphate synthase (CAD) gene, partial cds K11540 CAD carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase http://www.genome.jp/dbget-bin/www_bget?ko:K11540 P05990 7064 0.0e+00 CAD protein OS=Drosophila melanogaster GN=r PE=1 SV=3 PF02655//PF00113//PF01979//PF07478//PF02786//PF07722//PF02729 ATP-grasp domain//Enolase, C-terminal TIM barrel domain//Amidohydrolase family//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//Peptidase C26//Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GO:0006096//GO:0006207//GO:0006541//GO:0006571//GO:0006094//GO:0046436//GO:0006531//GO:0070409//GO:0006520//GO:0009252//GO:0006807//GO:0000162//GO:0006543//GO:0006206//GO:0006522//GO:0009094 glycolytic process//'de novo' pyrimidine nucleobase biosynthetic process//glutamine metabolic process//tyrosine biosynthetic process//gluconeogenesis//D-alanine metabolic process//aspartate metabolic process//carbamoyl phosphate biosynthetic process//cellular amino acid metabolic process//peptidoglycan biosynthetic process//nitrogen compound metabolic process//tryptophan biosynthetic process//glutamine catabolic process//pyrimidine nucleobase metabolic process//alanine metabolic process//L-phenylalanine biosynthetic process GO:0004634//GO:0016787//GO:0005524//GO:0016743//GO:0046872//GO:0004070//GO:0000287//GO:0008716//GO:0016812//GO:0016597 phosphopyruvate hydratase activity//hydrolase activity//ATP binding//carboxyl- or carbamoyltransferase activity//metal ion binding//aspartate carbamoyltransferase activity//magnesium ion binding//D-alanine-D-alanine ligase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides//amino acid binding GO:0009347//GO:0000015 aspartate carbamoyltransferase complex//phosphopyruvate hydratase complex KOG0370 Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) Cluster-8309.35805 BP_3 7573.83 252.94 1735 91094027 XP_967626.1 1283 1.9e-138 PREDICTED: translocating chain-associated membrane protein 1 isoform X1 [Tribolium castaneum]>gi|270003137|gb|EEZ99584.1| hypothetical protein TcasGA2_TC001570 [Tribolium castaneum] -- -- -- -- -- K14010 TRAM1 translocating chain-associated membrane protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14010 Q5XI41 620 5.9e-63 Translocating chain-associated membrane protein 1 OS=Rattus norvegicus GN=Tram1 PE=2 SV=3 PF03798 TLC domain -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1608 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.35806 BP_3 14.08 0.79 1149 642915775 XP_008200074.1 475 6.2e-45 PREDICTED: translocating chain-associated membrane protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14010 TRAM1 translocating chain-associated membrane protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14010 Q9GKZ4 311 2.7e-27 Translocating chain-associated membrane protein 1 OS=Bos taurus GN=TRAM1 PE=2 SV=3 PF03798//PF04901 TLC domain//Receptor activity modifying family GO:0015031//GO:0006886//GO:0008277 protein transport//intracellular protein transport//regulation of G-protein coupled receptor protein signaling pathway GO:0008565 protein transporter activity GO:0016021 integral component of membrane KOG1608 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.35807 BP_3 5116.51 81.06 3334 270010125 EFA06573.1 1630 2.1e-178 hypothetical protein TcasGA2_TC009484 [Tribolium castaneum] 642927258 XM_969189.2 206 4.61909e-101 PREDICTED: Tribolium castaneum uncharacterized LOC663129 (LOC663129), mRNA K17776 MTX metaxin http://www.genome.jp/dbget-bin/www_bget?ko:K17776 Q2L969 275 1.2e-22 Metaxin-2 OS=Sus scrofa GN=MTX2 PE=2 SV=1 PF13903 PMP-22/EMP/MP20/Claudin tight junction -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.35808 BP_3 199.95 4.66 2361 270016968 EFA13414.1 2409 7.0e-269 hypothetical protein TcasGA2_TC010300 [Tribolium castaneum] 701368608 XM_010009070.1 66 2.18084e-23 PREDICTED: Chaetura pelagica tripartite motif containing 37 (TRIM37), mRNA K10608 TRIM37, MUL tripartite motif-containing protein 37 http://www.genome.jp/dbget-bin/www_bget?ko:K10608 Q6PCX9 1742 6.4e-193 E3 ubiquitin-protein ligase TRIM37 OS=Mus musculus GN=Trim37 PE=1 SV=1 PF00917//PF00643//PF01442//PF04632 MATH domain//B-box zinc finger//Apolipoprotein A1/A4/E domain//Fusaric acid resistance protein family GO:0042157//GO:0006869//GO:0006810 lipoprotein metabolic process//lipid transport//transport GO:0008270//GO:0008289//GO:0005515 zinc ion binding//lipid binding//protein binding GO:0005576//GO:0005622//GO:0005886 extracellular region//intracellular//plasma membrane -- -- Cluster-8309.35811 BP_3 893.13 42.53 1304 546674022 ERL85515.1 565 2.6e-55 hypothetical protein D910_02934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15330 182 2.7e-12 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35812 BP_3 42.86 0.99 2377 478258626 ENN78676.1 1968 9.7e-218 hypothetical protein YQE_04848, partial [Dendroctonus ponderosae]>gi|546685782|gb|ERL95231.1| hypothetical protein D910_12498, partial [Dendroctonus ponderosae] 124303520 DQ872653.2 149 1.59277e-69 Carassius auratus HSP60 mRNA, complete cds K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 O02649 1756 1.5e-194 60 kDa heat shock protein, mitochondrial OS=Drosophila melanogaster GN=Hsp60 PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-8309.35813 BP_3 3629.51 87.24 2297 559783744 AHB18586.1 2342 4.0e-261 heat shock 60 kDa protein [Leptinotarsa decemlineata] 124303520 DQ872653.2 149 1.53837e-69 Carassius auratus HSP60 mRNA, complete cds K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 O02649 2089 3.6e-233 60 kDa heat shock protein, mitochondrial OS=Drosophila melanogaster GN=Hsp60 PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-8309.35816 BP_3 345.07 5.14 3525 546673060 ERL84737.1 1807 6.7e-199 hypothetical protein D910_02162 [Dendroctonus ponderosae] 642918235 XM_008193202.1 74 1.16789e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00130//PF00168//PF09202 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain//Rio2, N-terminal GO:0035556//GO:0006468//GO:0009069//GO:0016310 intracellular signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0005515 ATP binding//protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.35817 BP_3 43.17 1.56 1622 478250474 ENN70969.1 907 7.1e-95 hypothetical protein YQE_12370, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13678 128 6.2e-06 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF09202//PF00130 Rio2, N-terminal//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0009069//GO:0035556//GO:0006468//GO:0016310 serine family amino acid metabolic process//intracellular signal transduction//protein phosphorylation//phosphorylation GO:0004674//GO:0005524 protein serine/threonine kinase activity//ATP binding -- -- -- -- Cluster-8309.35821 BP_3 5552.00 446.55 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35822 BP_3 91.00 7.23 898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35823 BP_3 696.46 11.08 3322 91091942 XP_975905.1 1039 7.2e-110 PREDICTED: E3 ubiquitin-protein ligase RNF126 isoform X2 [Tribolium castaneum] 170048596 XM_001870670.1 46 4.04095e-12 Culex quinquefasciatus RING finger protein 126-B, mRNA K11982 RNF115_126 E3 ubiquitin-protein ligase RNF115/126 http://www.genome.jp/dbget-bin/www_bget?ko:K11982 Q9D0C1 380 7.7e-35 E3 ubiquitin-protein ligase RNF115 OS=Mus musculus GN=Rnf115 PE=1 SV=1 PF14634//PF12861//PF17123//PF12678//PF00097//PF13639//PF01155 zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0016567//GO:0006464 protein ubiquitination//cellular protein modification process GO:0004842//GO:0016151//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//nickel cation binding//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.35824 BP_3 905.08 25.14 2027 478262423 ENN81094.1 2754 5.9e-309 hypothetical protein YQE_02462, partial [Dendroctonus ponderosae]>gi|546673644|gb|ERL85208.1| hypothetical protein D910_02629 [Dendroctonus ponderosae] 591382847 XM_007065827.1 101 6.52995e-43 PREDICTED: Chelonia mydas cullin-associated and neddylation-dissociated 1 (CAND1), transcript variant X1, mRNA K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 1898 4.4e-211 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1824 TATA-binding protein-interacting protein Cluster-8309.35827 BP_3 9870.00 235.01 2316 751657249 AJF94883.1 2255 5.0e-251 C1 family cathepsin L11 [Tenebrio molitor] 801381562 XM_012198882.1 120 2.04976e-53 PREDICTED: Atta cephalotes digestive cysteine proteinase 1 (LOC105617316), mRNA -- -- -- -- P13277 627 1.2e-63 Digestive cysteine proteinase 1 OS=Homarus americanus GN=LCP1 PE=1 SV=2 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.35828 BP_3 1341.18 91.27 1000 264667343 ACY71257.1 1048 1.9e-111 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 558 5.3e-56 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF03868//PF01159 Ribosomal protein L6, N-terminal domain//Ribosomal protein L6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1694 60s ribosomal protein L6 Cluster-8309.35829 BP_3 14.03 0.38 2071 736236361 XP_010783741.1 362 1.4e-31 PREDICTED: 40S ribosomal protein S5-like, partial [Notothenia coriiceps] 559783393 KC571168.1 112 5.12309e-49 Lyclene sp. 1 CHS-2013 voucher UMD-JZCS038 ribosomal protein S5 (rpS5) gene, partial cds K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 Q24186 356 2.9e-32 40S ribosomal protein S5a OS=Drosophila melanogaster GN=RpS5a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-8309.3583 BP_3 35.53 0.53 3528 91091098 XP_968555.1 689 2.9e-69 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270014078|gb|EFA10526.1| hypothetical protein TcasGA2_TC012778 [Tribolium castaneum] -- -- -- -- -- K05684 ABCG8 ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2) http://www.genome.jp/dbget-bin/www_bget?ko:K05684 Q9H221 250 9.7e-20 ATP-binding cassette sub-family G member 8 OS=Homo sapiens GN=ABCG8 PE=1 SV=1 PF08352//PF00005 Oligopeptide/dipeptide transporter, C-terminal region//ABC transporter GO:0006200//GO:0015833 obsolete ATP catabolic process//peptide transport GO:0005524//GO:0000166//GO:0016887 ATP binding//nucleotide binding//ATPase activity -- -- KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.35832 BP_3 2284.50 75.72 1746 478252606 ENN73011.1 995 4.8e-105 hypothetical protein YQE_10346, partial [Dendroctonus ponderosae]>gi|546677977|gb|ERL88706.1| hypothetical protein D910_06088 [Dendroctonus ponderosae] 755890983 XM_005189166.2 182 5.26282e-88 PREDICTED: Musca domestica cdc42 homolog (LOC101898849), transcript variant X2, mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 Q17031 953 1.5e-101 Cdc42 homolog OS=Anopheles gambiae GN=Cdc42 PE=2 SV=2 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.35833 BP_3 1260.05 67.61 1190 478252801 ENN73192.1 937 1.7e-98 hypothetical protein YQE_10171, partial [Dendroctonus ponderosae] 462301115 APGK01050708.1 87 2.29488e-35 Dendroctonus ponderosae Seq01050718, whole genome shotgun sequence -- -- -- -- Q969T9 407 2.0e-38 WW domain-binding protein 2 OS=Homo sapiens GN=WBP2 PE=1 SV=1 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0032266//GO:0043130 phosphatidylinositol-3-phosphate binding//ubiquitin binding -- -- KOG3294 WW domain binding protein WBP-2, contains GRAM domain Cluster-8309.35836 BP_3 35.89 1.38 1546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35837 BP_3 1047.99 9.18 5796 642936633 XP_008198516.1 2964 0.0e+00 PREDICTED: trafficking kinesin-binding protein milt isoform X1 [Tribolium castaneum]>gi|270013061|gb|EFA09509.1| hypothetical protein TcasGA2_TC011611 [Tribolium castaneum] 642936634 XM_008200295.1 347 3.35166e-179 PREDICTED: Tribolium castaneum trafficking kinesin-binding protein milt (LOC661863), transcript variant X2, mRNA K15369 TRAK1 trafficking kinesin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15369 Q960V3 741 1.8e-76 Trafficking kinesin-binding protein milt OS=Drosophila melanogaster GN=milt PE=1 SV=1 PF02262//PF04513//PF01496//PF06009//PF04111//PF15182 CBL proto-oncogene N-terminal domain 1//Baculovirus polyhedron envelope protein, PEP, C terminus//V-type ATPase 116kDa subunit family//Laminin Domain II//Autophagy protein Apg6//Otospiralin GO:0015991//GO:0007605//GO:0006914//GO:0007165//GO:0007166//GO:0015992//GO:0007155 ATP hydrolysis coupled proton transport//sensory perception of sound//autophagy//signal transduction//cell surface receptor signaling pathway//proton transport//cell adhesion GO:0005198//GO:0015078//GO:0004871 structural molecule activity//hydrogen ion transmembrane transporter activity//signal transducer activity GO:0019031//GO:0005634//GO:0019028//GO:0033179 viral envelope//nucleus//viral capsid//proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.35840 BP_3 139.01 1.59 4499 91094249 XP_968795.1 801 3.8e-82 PREDICTED: neurofilament heavy polypeptide [Tribolium castaneum]>gi|270016266|gb|EFA12712.1| hypothetical protein TcasGA2_TC002346 [Tribolium castaneum] -- -- -- -- -- K00653 CDY chromodomain protein Y http://www.genome.jp/dbget-bin/www_bget?ko:K00653 Q9D5D8 198 1.3e-13 Chromodomain Y-like protein 2 OS=Mus musculus GN=Cdyl2 PE=1 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG0016 Enoyl-CoA hydratase/isomerase Cluster-8309.35841 BP_3 102.78 2.73 2105 642915997 XP_008190849.1 2034 1.9e-225 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O01761 400 2.3e-37 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00041//PF13895//PF06220 Fibronectin type III domain//Immunoglobulin domain//U1 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.35842 BP_3 24.43 0.62 2197 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35844 BP_3 59.37 2.38 1494 751447415 XP_011177845.1 246 2.9e-18 PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751447417|ref|XP_011177846.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751797807|ref|XP_011208789.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera dorsalis] -- -- -- -- -- K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P00430 136 6.8e-07 Cytochrome c oxidase subunit 7C, mitochondrial OS=Bos taurus GN=COX7C PE=1 SV=3 PF02935 Cytochrome c oxidase subunit VIIc GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.35845 BP_3 5376.28 38.49 7024 91079915 XP_967163.1 3071 0.0e+00 PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|642918342|ref|XP_008196887.1| PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|270003264|gb|EEZ99711.1| hypothetical protein TcasGA2_TC002472 [Tribolium castaneum] 642918341 XM_008198665.1 668 0 PREDICTED: Tribolium castaneum cold shock domain-containing protein E1 (LOC655517), transcript variant X2, mRNA -- -- -- -- P18395 1330 1.1e-144 Cold shock domain-containing protein E1 OS=Rattus norvegicus GN=Csde1 PE=2 SV=1 PF00313//PF02099 'Cold-shock' DNA-binding domain//Josephin GO:0006355 regulation of transcription, DNA-templated GO:0008242//GO:0003677 omega peptidase activity//DNA binding -- -- KOG2935 Ataxin 3/Josephin Cluster-8309.35846 BP_3 69.94 2.32 1746 332372484 AEE61384.1 1393 3.4e-151 unknown [Dendroctonus ponderosae]>gi|478263185|gb|ENN81578.1| hypothetical protein YQE_02107, partial [Dendroctonus ponderosae]>gi|546681813|gb|ERL91839.1| hypothetical protein D910_09164 [Dendroctonus ponderosae] 702073666 FO906013.1 51 3.49717e-15 Leptosphaeria maculans lepidii ibcn84_scaffold00011 complete sequence K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P12345 1082 1.6e-116 Aspartate aminotransferase, mitochondrial OS=Oryctolagus cuniculus GN=GOT2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.35848 BP_3 1265.89 15.78 4159 642926377 XP_008194900.1 1602 4.7e-175 PREDICTED: serine proteinase stubble [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17538 263 3.5e-21 Chymotrypsinogen B OS=Homo sapiens GN=CTRB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.35850 BP_3 7206.80 283.50 1517 642918278 XP_967503.3 720 3.2e-73 PREDICTED: nucleoside diphosphate kinase [Tribolium castaneum] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 P08879 629 4.7e-64 Nucleoside diphosphate kinase OS=Drosophila melanogaster GN=awd PE=1 SV=3 PF00334 Nucleoside diphosphate kinase GO:0006183//GO:0006228//GO:0006165//GO:0006241//GO:0006206//GO:0006144 GTP biosynthetic process//UTP biosynthetic process//nucleoside diphosphate phosphorylation//CTP biosynthetic process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.35852 BP_3 12.03 0.38 1835 189240985 XP_001808932.1 1154 1.8e-123 PREDICTED: probable cytosolic Fe-S cluster assembly factor CPIJ010948 [Tribolium castaneum]>gi|270012992|gb|EFA09440.1| hypothetical protein TcasGA2_TC010652 [Tribolium castaneum] 462325677 APGK01041744.1 56 6.11301e-18 Dendroctonus ponderosae Seq01041754, whole genome shotgun sequence -- -- -- -- Q7PWB8 932 4.2e-99 Probable cytosolic Fe-S cluster assembly factor AGAP009023 OS=Anopheles gambiae GN=AGAP009023 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2439 Nuclear architecture related protein Cluster-8309.35855 BP_3 377.76 6.07 3293 189234512 XP_972107.2 2248 4.6e-250 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X2 [Tribolium castaneum] 642913556 XM_967014.3 667 0 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X2, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 P82252 1249 1.3e-135 b(0,+)-type amino acid transporter 1 OS=Rattus norvegicus GN=Slc7a9 PE=1 SV=1 PF00324//PF04544//PF01194//PF13520 Amino acid permease//Herpesvirus egress protein UL20//RNA polymerases N / 8 kDa subunit//Amino acid permease GO:0006351//GO:0006865//GO:0055085//GO:0006144//GO:0019058//GO:0006810//GO:0003333//GO:0006206 transcription, DNA-templated//amino acid transport//transmembrane transport//purine nucleobase metabolic process//viral life cycle//transport//amino acid transmembrane transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0015171//GO:0003677 DNA-directed RNA polymerase activity//amino acid transmembrane transporter activity//DNA binding GO:0016020//GO:0005730 membrane//nucleolus -- -- Cluster-8309.35856 BP_3 5406.33 219.11 1481 801376388 XP_012064022.1 747 2.3e-76 PREDICTED: calmodulin [Atta cephalotes] 642914577 XM_967063.3 531 0 PREDICTED: Tribolium castaneum calmodulin (LOC660864), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 Q8STF0 744 2.1e-77 Calmodulin OS=Strongylocentrotus intermedius PE=2 SV=3 PF10104//PF13405//PF10591//PF13833//PF13499//PF12763//PF02563//PF03874//PF00036//PF13202 Di-sulfide bridge nucleocytoplasmic transport domain//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//Polysaccharide biosynthesis/export protein//RNA polymerase Rpb4//EF hand//EF hand GO:0006206//GO:0006351//GO:0006144//GO:0015774//GO:0007165//GO:0006998//GO:0006611//GO:0006406 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//polysaccharide transport//signal transduction//nuclear envelope organization//protein export from nucleus//mRNA export from nucleus GO:0005509//GO:0015159//GO:0005515//GO:0003899 calcium ion binding//polysaccharide transmembrane transporter activity//protein binding//DNA-directed RNA polymerase activity GO:0016020//GO:0005578//GO:0005730//GO:0031965 membrane//proteinaceous extracellular matrix//nucleolus//nuclear membrane KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35857 BP_3 765.00 8.87 4450 302371202 NP_001180578.1 1511 1.8e-164 Z9 acyl-CoA desaturase B [Tribolium castaneum]>gi|642938808|ref|XP_008199928.1| PREDICTED: Z9 acyl-CoA desaturase B isoform X1 [Tribolium castaneum]>gi|642938810|ref|XP_008199929.1| PREDICTED: Z9 acyl-CoA desaturase B isoform X1 [Tribolium castaneum]>gi|270015965|gb|EFA12413.1| hypothetical protein TcasGA2_TC016415 [Tribolium castaneum]>gi|300432600|gb|ADK13055.1| Z9 acyl-CoA desaturase B [Tribolium castaneum] -- -- -- -- -- K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 Q6US81 1006 2.6e-107 Acyl-CoA Delta(11) desaturase OS=Spodoptera littoralis PE=1 SV=1 PF05371//PF00487 Phage major coat protein, Gp8//Fatty acid desaturase GO:0006633//GO:0055114//GO:0006629 fatty acid biosynthetic process//oxidation-reduction process//lipid metabolic process GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.35858 BP_3 199.36 18.33 816 571330966 AHF27415.1 790 1.3e-81 putative sugar transporter 3_1 [Phaedon cochleariae]>gi|571330968|gb|AHF27416.1| putative sugar transporter 3_2 [Phaedon cochleariae] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 P58354 307 5.5e-27 Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus GN=SLC2A8 PE=2 SV=2 PF00083//PF01769//PF07690 Sugar (and other) transporter//Divalent cation transporter//Major Facilitator Superfamily GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0022857//GO:0008324 transmembrane transporter activity//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.35859 BP_3 1197.26 80.23 1011 91093903 XP_969673.1 498 1.2e-47 PREDICTED: translocon-associated protein subunit delta [Tribolium castaneum]>gi|270014509|gb|EFA10957.1| hypothetical protein TcasGA2_TC004117 [Tribolium castaneum] -- -- -- -- -- K04571 SSR4 translocon-associated protein subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K04571 Q62186 245 1.1e-19 Translocon-associated protein subunit delta OS=Mus musculus GN=Ssr4 PE=2 SV=1 PF08030//PF05404 Ferric reductase NAD binding domain//Translocon-associated protein, delta subunit precursor (TRAP-delta) GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG4088 Translocon-associated complex TRAP, delta subunit Cluster-8309.35860 BP_3 1210.00 17.63 3599 270007818 EFA04266.1 747 5.6e-76 hypothetical protein TcasGA2_TC014556 [Tribolium castaneum] 667677333 AE014297.3 74 1.19266e-27 Drosophila melanogaster chromosome 3R -- -- -- -- P41046 268 8.1e-22 Centrosomal and chromosomal factor OS=Drosophila melanogaster GN=corto PE=1 SV=2 PF04685 Protein of unknown function, DUF608 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.35862 BP_3 10.50 0.38 1614 531450771 AGT57862.1 531 2.8e-51 cytochrome P450 347c1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964T2 389 3.4e-36 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.35863 BP_3 1545.97 22.19 3650 91075960 XP_969014.1 2170 5.6e-241 PREDICTED: sarcalumenin [Tribolium castaneum]>gi|270014655|gb|EFA11103.1| hypothetical protein TcasGA2_TC004701 [Tribolium castaneum] 642910282 XM_963921.3 115 1.95396e-50 PREDICTED: Tribolium castaneum sarcalumenin (LOC657463), mRNA -- -- -- -- Q7TQ48 1007 1.7e-107 Sarcalumenin OS=Mus musculus GN=Srl PE=1 SV=1 PF07382//PF01926//PF03193 Histone H1-like nucleoprotein HC2//50S ribosome-binding GTPase//Protein of unknown function, DUF258 GO:0030261//GO:0006184 chromosome condensation//obsolete GTP catabolic process GO:0003924//GO:0005525//GO:0003677 GTPase activity//GTP binding//DNA binding -- -- KOG1954 Endocytosis/signaling protein EHD1 Cluster-8309.35864 BP_3 346.35 4.04 4420 646714946 KDR18732.1 4412 0.0e+00 Xanthine dehydrogenase [Zootermopsis nevadensis] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P10351 4033 0.0e+00 Xanthine dehydrogenase OS=Drosophila melanogaster GN=ry PE=2 SV=2 PF00111//PF01799//PF00941//PF02738 2Fe-2S iron-sulfur cluster binding domain//[2Fe-2S] binding domain//FAD binding domain in molybdopterin dehydrogenase//Molybdopterin-binding domain of aldehyde dehydrogenase GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0051536//GO:0009055//GO:0016491//GO:0046872 iron-sulfur cluster binding//electron carrier activity//oxidoreductase activity//metal ion binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.35865 BP_3 3553.39 69.73 2748 815792945 XP_012217083.1 2629 2.5e-294 PREDICTED: endoplasmin [Linepithema humile] 332376397 BT128381.1 577 0 Dendroctonus ponderosae clone DPO089_B16 unknown mRNA K09487 HSP90B, TRA1 heat shock protein 90kDa beta http://www.genome.jp/dbget-bin/www_bget?ko:K09487 Q22235 2113 7.1e-236 Endoplasmin homolog OS=Caenorhabditis elegans GN=enpl-1 PE=3 SV=1 PF15050//PF00183 SCIMP protein//Hsp90 protein GO:0006457//GO:0006950 protein folding//response to stress GO:0051082//GO:0005524 unfolded protein binding//ATP binding GO:0001772//GO:0016021//GO:0097197 immunological synapse//integral component of membrane//tetraspanin-enriched microdomain KOG0020 Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family Cluster-8309.35866 BP_3 65.82 0.39 8349 189236706 XP_974173.2 1532 1.2e-166 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 349 3.73777e-180 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 652 5.6e-66 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.35867 BP_3 145.23 0.69 10434 642936905 XP_008194432.1 1830 4.3e-201 PREDICTED: fasciclin-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 1203 8.9e-130 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 PF04433//PF15427 SWIRM domain//S100P-binding protein -- -- GO:0048306//GO:0005515 calcium-dependent protein binding//protein binding -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.35868 BP_3 116.81 0.97 6084 189236215 XP_975776.2 2722 9.2e-305 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] 820834819 XM_003689675.2 267 1.04281e-134 PREDICTED: Apis florea alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like (LOC100865289), mRNA K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 921 2.6e-97 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF02358//PF00982 Trehalose-phosphatase//Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.35869 BP_3 1174.00 63.99 1176 91085813 XP_974738.1 535 7.0e-52 PREDICTED: YY1-associated factor 2 [Tribolium castaneum]>gi|270010133|gb|EFA06581.1| hypothetical protein TcasGA2_TC009493 [Tribolium castaneum] -- -- -- -- -- K11468 YAF2 YY1-associated factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11468 Q99LW6 338 2.0e-30 YY1-associated factor 2 OS=Mus musculus GN=Yaf2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- KOG4477 RING1 interactor RYBP and related Zn-finger-containing proteins Cluster-8309.35870 BP_3 208.13 3.34 3297 642926804 XP_008195020.1 1279 1.1e-137 PREDICTED: vacuole membrane protein 1 isoform X2 [Tribolium castaneum] 241594857 XM_002404356.1 107 4.93689e-46 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q6INE8 937 2.0e-99 Vacuole membrane protein 1 OS=Xenopus laevis GN=vmp1 PE=2 SV=1 PF00323 Mammalian defensin GO:0006952 defense response -- -- GO:0005576 extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.35871 BP_3 31.77 0.58 2949 642935097 XP_008197884.1 1820 1.7e-200 PREDICTED: probable RNA methyltransferase bin3 isoform X1 [Tribolium castaneum]>gi|270013396|gb|EFA09844.1| hypothetical protein TcasGA2_TC011992 [Tribolium castaneum] -- -- -- -- -- K15190 MEPCE, BCDIN3 7SK snRNA methylphosphate capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15190 Q8K3A9 597 4.7e-60 7SK snRNA methylphosphate capping enzyme OS=Mus musculus GN=Mepce PE=1 SV=2 PF06859//PF05401//PF02390//PF08241//PF03810//PF05175//PF01135//PF08123//PF05958 Bicoid-interacting protein 3 (Bin3)//Nodulation protein S (NodS)//Putative methyltransferase//Methyltransferase domain//Importin-beta N-terminal domain//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Histone methylation protein DOT1//tRNA (Uracil-5-)-methyltransferase GO:0006396//GO:0008033//GO:0006554//GO:0006464//GO:0009312//GO:0006886//GO:0009877//GO:0006479//GO:0009451//GO:0006400//GO:0046500//GO:0008152 RNA processing//tRNA processing//lysine catabolic process//cellular protein modification process//oligosaccharide biosynthetic process//intracellular protein transport//nodulation//protein methylation//RNA modification//tRNA modification//S-adenosylmethionine metabolic process//metabolic process GO:0008168//GO:0008176//GO:0004719//GO:0018024//GO:0008757//GO:0008536//GO:0008173 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//histone-lysine N-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//Ran GTPase binding//RNA methyltransferase activity -- -- KOG2899 Predicted methyltransferase Cluster-8309.35873 BP_3 115.27 1.37 4334 642933803 XP_008197345.1 467 2.0e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 8.18225e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q9CZG3 131 7.5e-06 COMM domain-containing protein 8 OS=Mus musculus GN=Commd8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35875 BP_3 58.00 4.02 987 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08145 BOP1NT (NUC169) domain GO:0006364 rRNA processing -- -- -- -- -- -- Cluster-8309.35877 BP_3 221.91 7.47 1724 270001643 EEZ98090.1 372 8.2e-33 hypothetical protein TcasGA2_TC000503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26352 128 6.6e-06 Thymosin beta-12 OS=Oncorhynchus mykiss PE=1 SV=2 PF01290 Thymosin beta-4 family GO:0007015 actin filament organization GO:0003785 actin monomer binding -- -- KOG4794 Thymosin beta Cluster-8309.35878 BP_3 353.00 10.02 1990 270001855 EEZ98302.1 519 8.5e-50 hypothetical protein TcasGA2_TC000755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5M3 296 2.5e-25 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.35880 BP_3 1.00 0.61 367 835482914 AKM70276.1 143 6.2e-07 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35881 BP_3 2002.34 41.47 2619 546686007 ERL95413.1 3162 0.0e+00 hypothetical protein D910_12677 [Dendroctonus ponderosae] 288872186 NM_001172404.1 254 7.51072e-128 Apis mellifera NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (Ndufs1), mRNA K03934 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03934 Q94511 2538 3.5e-285 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND75 PE=2 SV=3 PF10588//PF00111//PF09326//PF00384//PF00205//PF00211 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//2Fe-2S iron-sulfur cluster binding domain//NADH-ubiquinone oxidoreductase subunit G, C-terminal//Molybdopterin oxidoreductase//Thiamine pyrophosphate enzyme, central domain//Adenylate and Guanylate cyclase catalytic domain GO:0055114//GO:0035556//GO:0009190//GO:0006118 oxidation-reduction process//intracellular signal transduction//cyclic nucleotide biosynthetic process//obsolete electron transport GO:0016849//GO:0030976//GO:0000287//GO:0009055//GO:0051536//GO:0016651//GO:0016491 phosphorus-oxygen lyase activity//thiamine pyrophosphate binding//magnesium ion binding//electron carrier activity//iron-sulfur cluster binding//oxidoreductase activity, acting on NAD(P)H//oxidoreductase activity -- -- KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit Cluster-8309.35882 BP_3 924.13 17.49 2839 642930706 XP_008199995.1 1616 7.6e-177 PREDICTED: hepatocyte growth factor-regulated tyrosine kinase substrate [Tribolium castaneum]>gi|270012668|gb|EFA09116.1| hypothetical protein TcasGA2_TC015976 [Tribolium castaneum] -- -- -- -- -- K12182 HGS, HRS, VPS27 hepatocyte growth factor-regulated tyrosine kinase substrate http://www.genome.jp/dbget-bin/www_bget?ko:K12182 Q960X8 1213 1.7e-131 Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster GN=Hrs PE=1 SV=1 PF01363//PF04632//PF00790 FYVE zinc finger//Fusaric acid resistance protein family//VHS domain GO:0006810//GO:0006886 transport//intracellular protein transport GO:0046872 metal ion binding GO:0005886 plasma membrane KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.35883 BP_3 19329.47 1509.35 909 264667343 ACY71257.1 1048 1.8e-111 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 558 4.8e-56 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF01159//PF03868 Ribosomal protein L6e//Ribosomal protein L6, N-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1694 60s ribosomal protein L6 Cluster-8309.35884 BP_3 7687.90 855.22 725 270008722 EFA05170.1 453 1.4e-42 hypothetical protein TcasGA2_TC015299 [Tribolium castaneum] 264667356 GU120414.1 143 1.01757e-66 Chrysomela tremulae ribosomal protein S27 (RpS27) mRNA, complete cds K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 Q6ZWU9 380 1.7e-35 40S ribosomal protein S27 OS=Mus musculus GN=Rps27 PE=1 SV=3 PF01667 Ribosomal protein S27 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1779 40s ribosomal protein S27 Cluster-8309.35885 BP_3 25.49 0.33 3967 546683529 ERL93331.1 164 2.5e-08 hypothetical protein D910_10625, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35887 BP_3 76.35 0.69 5630 642924614 XP_008194364.1 1949 3.7e-215 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 7.8e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.35888 BP_3 418.91 103.28 487 821003176 XP_012365190.1 807 8.4e-84 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 46359621 AB122067.1 253 4.74913e-128 Crassostrea gigas mRNA for polyubiquitin, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 807 3.4e-85 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560//PF04452 Ubiquitin family//Ubiquitin-like domain//RNA methyltransferase GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35889 BP_3 265.00 3.91 3555 642911172 XP_008200610.1 1338 1.6e-144 PREDICTED: E3 ubiquitin-protein ligase KCMF1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P0J7 813 5.1e-85 E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens GN=KCMF1 PE=1 SV=2 PF00569//PF00096 Zinc finger, ZZ type//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1280 Uncharacterized conserved protein containing ZZ-type Zn-finger Cluster-8309.3589 BP_3 49.58 0.35 7081 270014059 EFA10507.1 1204 1.1e-128 hypothetical protein TcasGA2_TC012755 [Tribolium castaneum] 194763724 XM_001963947.1 63 3.07079e-21 Drosophila ananassae GF21316 (Dana\GF21316), mRNA -- -- -- -- -- -- -- -- PF02419//PF17121 PsbL protein//Zinc finger, C3HC4 type (RING finger) GO:0015979 photosynthesis GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane -- -- Cluster-8309.35890 BP_3 24887.23 2152.56 849 91084673 XP_968064.1 1123 3.3e-120 PREDICTED: 40S ribosomal protein S3a [Tribolium castaneum]>gi|270008925|gb|EFA05373.1| hypothetical protein TcasGA2_TC015539 [Tribolium castaneum] 70909476 AM048925.1 266 5.05731e-135 Timarcha balearica mRNA for ribosomal protein S3Ae (rpS3Ae gene) K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 Q5G5C4 1113 2.0e-120 40S ribosomal protein S3a OS=Periplaneta americana GN=Parcxpwex01 PE=2 SV=1 PF01015//PF04083 Ribosomal S3Ae family//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0006412//GO:0042254 lipid metabolic process//translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1628 40S ribosomal protein S3A Cluster-8309.35892 BP_3 42307.93 1382.27 1767 91081963 XP_975913.1 514 2.9e-49 PREDICTED: nuclease-sensitive element-binding protein 1 isoform X2 [Tribolium castaneum] 642921885 XM_961501.3 225 6.65194e-112 PREDICTED: Tribolium castaneum Y-box factor homolog (LOC656063), transcript variant X1, mRNA K06099 CSDA, ZONAB cold shock domain protein A http://www.genome.jp/dbget-bin/www_bget?ko:K06099 P41824 393 1.3e-36 Y-box factor homolog OS=Aplysia californica PE=2 SV=1 PF00313//PF00621 'Cold-shock' DNA-binding domain//RhoGEF domain GO:0006355//GO:0035023//GO:0043087 regulation of transcription, DNA-templated//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0003677//GO:0005089 DNA binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.35893 BP_3 1854.88 54.51 1932 270013857 EFA10305.1 192 6.8e-12 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35894 BP_3 12.47 0.31 2210 646682520 KDR02319.1 1275 2.1e-137 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.56435e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 934 2.9e-99 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF07714//PF00937//PF00069 Protein tyrosine kinase//Coronavirus nucleocapsid protein//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.35895 BP_3 16147.00 136.89 5977 665798417 XP_008547083.1 2016 6.6e-223 PREDICTED: collagen alpha-1(IV) chain [Microplitis demolitor] -- -- -- -- -- K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 P02462 1845 1.8e-204 Collagen alpha-1(IV) chain OS=Homo sapiens GN=COL4A1 PE=1 SV=3 PF12529//PF01413//PF02948 Xylosyltransferase C terminal//C-terminal tandem repeated domain in type 4 procollagen//Amelogenin GO:0006024//GO:0030206//GO:0007275 glycosaminoglycan biosynthetic process//chondroitin sulfate biosynthetic process//multicellular organismal development GO:0030158//GO:0005201 protein xylosyltransferase activity//extracellular matrix structural constituent GO:0005581//GO:0005578 collagen trimer//proteinaceous extracellular matrix KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.35896 BP_3 337.00 15.02 1373 478254585 ENN74828.1 554 5.1e-54 hypothetical protein YQE_08601, partial [Dendroctonus ponderosae]>gi|546671540|gb|ERL83809.1| hypothetical protein D910_01058 [Dendroctonus ponderosae]>gi|546680245|gb|ERL90561.1| hypothetical protein D910_07909 [Dendroctonus ponderosae] 641673954 XM_003246814.2 57 1.2634e-18 PREDICTED: Acyrthosiphon pisum protein Dr1 (LOC100161049), transcript variant X2, mRNA -- -- -- -- Q9VJQ5 465 4.4e-45 Protein Dr1 OS=Drosophila melanogaster GN=NC2beta PE=1 SV=1 PF00125//PF15510//PF05634 Core histone H2A/H2B/H3/H4//Centromere kinetochore component W//APO RNA-binding GO:0051382//GO:0007067 kinetochore assembly//mitotic nuclear division GO:0003723//GO:0003677 RNA binding//DNA binding -- -- KOG0871 Class 2 transcription repressor NC2, beta subunit (Dr1) Cluster-8309.35897 BP_3 15.86 0.59 1598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.35898 BP_3 31.00 1.58 1236 309318773 BAJ23047.1 605 5.6e-60 peptidoglycan-recognition protein-SC2 [Tenebrio molitor] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V4X2 412 5.5e-39 Peptidoglycan-recognition protein SC2 OS=Drosophila melanogaster GN=PGRP-SC2 PE=2 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009252//GO:0009253//GO:0006807 peptidoglycan biosynthetic process//peptidoglycan catabolic process//nitrogen compound metabolic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.35902 BP_3 1.24 0.52 406 91084415 XP_967749.1 363 2.1e-32 PREDICTED: macrophage migration inhibitory factor homolog [Tribolium castaneum]>gi|270008846|gb|EFA05294.1| hypothetical protein TcasGA2_TC015451 [Tribolium castaneum] -- -- -- -- -- K07253 MIF phenylpyruvate tautomerase http://www.genome.jp/dbget-bin/www_bget?ko:K07253 P81748 174 7.2e-12 Macrophage migration inhibitory factor homolog OS=Trichuris trichiura PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1759 Macrophage migration inhibitory factor Cluster-8309.35903 BP_3 29.75 0.32 4767 512926764 XP_004931167.1 670 6.3e-67 PREDICTED: GTP-binding protein SAR1b [Bombyx mori] 676480291 XM_009063766.1 50 3.47681e-14 Lottia gigantea hypothetical protein mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q9QVY3 541 2.4e-53 GTP-binding protein SAR1b OS=Cricetulus griseus GN=SAR1B PE=1 SV=1 PF04670//PF00071//PF00503//PF06858//PF05493//PF08650//PF00025//PF08477 Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//Nucleolar GTP-binding protein 1 (NOG1)//ATP synthase subunit H//DASH complex subunit Dad4//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0015991//GO:0008608//GO:0007186//GO:0007264//GO:0015992 signal transduction//ATP hydrolysis coupled proton transport//attachment of spindle microtubules to kinetochore//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//proton transport GO:0031683//GO:0003924//GO:0019001//GO:0004871//GO:0015078//GO:0005525 G-protein beta/gamma-subunit complex binding//GTPase activity//guanyl nucleotide binding//signal transducer activity//hydrogen ion transmembrane transporter activity//GTP binding GO:0072686//GO:0042729//GO:0033179 mitotic spindle//DASH complex//proton-transporting V-type ATPase, V0 domain KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.35904 BP_3 14.49 0.85 1115 91082141 XP_969473.1 663 9.6e-67 PREDICTED: integral membrane protein 2A [Tribolium castaneum]>gi|270007252|gb|EFA03700.1| hypothetical protein TcasGA2_TC013805 [Tribolium castaneum] -- -- -- -- -- K18264 ITM2B integral membrane protein 2B http://www.genome.jp/dbget-bin/www_bget?ko:K18264 Q3T0P7 179 5.2e-12 Integral membrane protein 2B OS=Bos taurus GN=ITM2B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4681 Uncharacterized conserved protein Cluster-8309.35906 BP_3 2368.00 90.71 1550 189240618 XP_001807780.1 402 2.4e-36 PREDICTED: uncharacterized protein LOC100142083 [Tribolium castaneum]>gi|642933744|ref|XP_008191491.1| PREDICTED: uncharacterized protein LOC100142083 [Tribolium castaneum]>gi|270013624|gb|EFA10072.1| hypothetical protein TcasGA2_TC012246 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35907 BP_3 878.00 28.08 1799 478254039 ENN74331.1 1722 2.5e-189 hypothetical protein YQE_09301, partial [Dendroctonus ponderosae]>gi|546686147|gb|ERL95533.1| hypothetical protein D910_12795 [Dendroctonus ponderosae] -- -- -- -- -- K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q96I99 1211 1.8e-131 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens GN=SUCLG2 PE=1 SV=2 PF00549 CoA-ligase GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.35908 BP_3 213.18 4.95 2369 642920758 XP_971086.2 1029 7.4e-109 PREDICTED: protein-L-isoaspartate(D-aspartate) O-methyltransferase [Tribolium castaneum] 242014347 XM_002427808.1 67 6.08439e-24 Pediculus humanus corporis protein-L-isoaspartate O-methyltransferase, putative, mRNA K00573 E2.1.1.77, pcm protein-L-isoaspartate(D-aspartate) O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00573 Q5F3N1 775 8.6e-81 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Gallus gallus GN=PCMT1 PE=2 SV=3 PF01209//PF08241//PF01596//PF05175//PF01135 ubiE/COQ5 methyltransferase family//Methyltransferase domain//O-methyltransferase//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006464//GO:0008152//GO:0006479//GO:0046500 cellular protein modification process//metabolic process//protein methylation//S-adenosylmethionine metabolic process GO:0008168//GO:0008171//GO:0004719 methyltransferase activity//O-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity -- -- KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.35909 BP_3 217.79 1.30 8384 642935636 XP_008198092.1 4502 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 6.69387e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.5e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF13180//PF00620//PF00595//PF08718 PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF)//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0017089//GO:0051861//GO:0005515 glycolipid transporter activity//glycolipid binding//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.35910 BP_3 261.69 8.22 1826 642915594 XP_008190680.1 1716 1.2e-188 PREDICTED: uncharacterized protein LOC655748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35911 BP_3 73.98 1.20 3271 91089643 XP_973832.1 1255 6.3e-135 PREDICTED: solute carrier family 25 member 38-A isoform X2 [Tribolium castaneum]>gi|270011349|gb|EFA07797.1| hypothetical protein TcasGA2_TC005358 [Tribolium castaneum] -- -- -- -- -- K15118 SLC25A38 solute carrier family 25, member 38 http://www.genome.jp/dbget-bin/www_bget?ko:K15118 Q08CI8 782 1.8e-81 Solute carrier family 25 member 38-A OS=Danio rerio GN=slc25a38a PE=2 SV=2 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0766 Predicted mitochondrial carrier protein Cluster-8309.35912 BP_3 1301.55 8.47 7700 91082255 XP_973064.1 2364 3.8e-263 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62046 915 1.6e-96 Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Mus musculus GN=Lrch1 PE=1 SV=2 PF00560//PF13855//PF00307 Leucine Rich Repeat//Leucine rich repeat//Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.35914 BP_3 279.82 0.89 15490 642931869 XP_008196762.1 2259 1.1e-250 PREDICTED: protein split ends isoform X1 [Tribolium castaneum] 642931870 XM_008198541.1 278 2.0438e-140 PREDICTED: Tribolium castaneum protein split ends (LOC661278), transcript variant X2, mRNA -- -- -- -- Q8SX83 1148 3.2e-123 Protein split ends OS=Drosophila melanogaster GN=spen PE=1 SV=2 PF00076//PF02532//PF16367//PF04406//PF00335 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//RNA recognition motif//Type IIB DNA topoisomerase//Tetraspanin family GO:0015979//GO:0006259 photosynthesis//DNA metabolic process GO:0003824//GO:0005524//GO:0003677//GO:0003676 catalytic activity//ATP binding//DNA binding//nucleic acid binding GO:0016021//GO:0009539//GO:0009523//GO:0016020//GO:0005694 integral component of membrane//photosystem II reaction center//photosystem II//membrane//chromosome KOG0112 Large RNA-binding protein (RRM superfamily) Cluster-8309.35915 BP_3 23.94 0.55 2378 264667419 ACY71295.1 524 2.7e-50 ribosomal protein L19 [Chrysomela tremula] 601036659 KJ028107.1 86 1.67435e-34 Diachasmimorpha longicaudata ribosomal protein L19 (rpl19) mRNA, complete cds K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 P36241 423 5.7e-40 60S ribosomal protein L19 OS=Drosophila melanogaster GN=RpL19 PE=1 SV=2 PF01280 Ribosomal protein L19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1696 60s ribosomal protein L19 Cluster-8309.35916 BP_3 735.24 7.12 5266 642925269 XP_008194486.1 1379 4.3e-149 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 790 3.5e-82 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF01542//PF03600//PF00939 Hepatitis C virus core protein//Citrate transporter//Sodium:sulfate symporter transmembrane region GO:0006814//GO:0055085//GO:0006810 sodium ion transport//transmembrane transport//transport GO:0005198//GO:0005215 structural molecule activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.35917 BP_3 147.85 3.32 2436 728418241 AIY68362.1 267 1.7e-20 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05992 SbmA/BacA-like family GO:0006810 transport GO:0005215 transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.3592 BP_3 7.00 0.51 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35921 BP_3 165.41 1.48 5688 642910851 XP_008193435.1 1733 4.1e-190 PREDICTED: arginine kinase isoform X1 [Tribolium castaneum] 290048170 GU396008.1 405 0 Helicoverpa armigera arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 P48610 1581 7.2e-174 Arginine kinase OS=Drosophila melanogaster GN=Argk PE=2 SV=2 PF02807//PF00217 ATP:guanido phosphotransferase, N-terminal domain//ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.35924 BP_3 165.51 4.23 2178 270007760 EFA04208.1 192 7.7e-12 hypothetical protein TcasGA2_TC014457, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PH91 152 1.4e-08 Single-pass membrane and coiled-coil domain-containing protein 4 homolog OS=Anopheles gambiae GN=AGAP003534 PE=3 SV=3 PF00522//PF00001 VPR/VPX protein//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0019058 G-protein coupled receptor signaling pathway//viral life cycle GO:0004930 G-protein coupled receptor activity GO:0042025//GO:0016021 host cell nucleus//integral component of membrane -- -- Cluster-8309.35925 BP_3 307.00 3.99 3997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00468 Ribosomal protein L34 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.35929 BP_3 363.43 15.86 1396 642913237 XP_008201451.1 717 6.5e-73 PREDICTED: zinc finger protein 830 [Tribolium castaneum] 828206332 XM_012701468.1 44 2.16573e-11 PREDICTED: Hydra vulgaris zinc finger protein 830-like (LOC100205964), mRNA K13104 ZNF830, CCDC16 zinc finger protein 830 http://www.genome.jp/dbget-bin/www_bget?ko:K13104 Q6DJ13 223 5.2e-17 Zinc finger protein 830 OS=Xenopus tropicalis GN=znf830 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3032 Uncharacterized conserved protein Cluster-8309.35930 BP_3 60.00 3.01 1252 642911041 XP_967134.2 1283 1.4e-138 PREDICTED: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase-like [Tribolium castaneum] -- -- -- -- -- K00078 DHDH dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) http://www.genome.jp/dbget-bin/www_bget?ko:K00078 Q6DF30 746 1.0e-77 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase OS=Xenopus tropicalis GN=dhdh PE=2 SV=1 PF02894//PF01408 Oxidoreductase family, C-terminal alpha/beta domain//Oxidoreductase family, NAD-binding Rossmann fold GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2741 Dimeric dihydrodiol dehydrogenase Cluster-8309.35931 BP_3 55.67 0.97 3048 91077610 XP_973618.1 1737 7.6e-191 PREDICTED: branched-chain-amino-acid aminotransferase, cytosolic [Tribolium castaneum]>gi|270001557|gb|EEZ98004.1| hypothetical protein TcasGA2_TC000403 [Tribolium castaneum] -- -- -- -- -- K00826 E2.6.1.42, ilvE branched-chain amino acid aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00826 P54690 1007 1.4e-107 Branched-chain-amino-acid aminotransferase, cytosolic OS=Rattus norvegicus GN=Bcat1 PE=1 SV=1 PF01063 Amino-transferase class IV GO:0009099//GO:0009097//GO:0008152//GO:0009098 valine biosynthetic process//isoleucine biosynthetic process//metabolic process//leucine biosynthetic process GO:0052655//GO:0003824//GO:0052654//GO:0052656 L-valine transaminase activity//catalytic activity//L-leucine transaminase activity//L-isoleucine transaminase activity -- -- KOG0975 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily Cluster-8309.35934 BP_3 6335.50 49.42 6471 91093785 XP_967374.1 2861 0.0e+00 PREDICTED: DNA mismatch repair protein Msh2 [Tribolium castaneum]>gi|270015917|gb|EFA12365.1| hypothetical protein TcasGA2_TC002071 [Tribolium castaneum] -- -- -- -- -- K08735 MSH2 DNA mismatch repair protein MSH2 http://www.genome.jp/dbget-bin/www_bget?ko:K08735 Q5XXB5 2011 1.1e-223 DNA mismatch repair protein Msh2 OS=Chlorocebus aethiops GN=MSH2 PE=2 SV=1 PF06305//PF00488//PF08038//PF05190//PF05192//PF05188 Protein of unknown function (DUF1049)//MutS domain V//TOM7 family//MutS family domain IV//MutS domain III//MutS domain II GO:0030150//GO:0006298 protein import into mitochondrial matrix//mismatch repair GO:0097159//GO:0030983//GO:1901363//GO:0005524 organic cyclic compound binding//mismatched DNA binding//heterocyclic compound binding//ATP binding GO:0005742//GO:0032300//GO:0044428//GO:0005887 mitochondrial outer membrane translocase complex//mismatch repair complex//nuclear part//integral component of plasma membrane KOG0219 Mismatch repair ATPase MSH2 (MutS family) Cluster-8309.35935 BP_3 149.44 1.47 5192 237681145 NP_001153717.1 4861 0.0e+00 ATPase, class II, type 9B [Tribolium castaneum]>gi|642928770|ref|XP_008195554.1| PREDICTED: ATPase, class II, type 9B isoform X1 [Tribolium castaneum]>gi|270010392|gb|EFA06840.1| hypothetical protein TcasGA2_TC009783 [Tribolium castaneum] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3531 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF00122//PF09003 E1-E2 ATPase//Bacteriophage lambda integrase, N-terminal domain GO:0015914//GO:0008152//GO:0006812//GO:0015074//GO:0015917 phospholipid transport//metabolic process//cation transport//DNA integration//aminophospholipid transport GO:0003677//GO:0005524//GO:0015662//GO:0004012//GO:0000166//GO:0008907//GO:0000287//GO:0046872 DNA binding//ATP binding//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//phospholipid-translocating ATPase activity//nucleotide binding//integrase activity//magnesium ion binding//metal ion binding GO:0016021 integral component of membrane KOG0210 P-type ATPase Cluster-8309.35936 BP_3 2111.28 62.34 1924 478254712 ENN74953.1 1315 4.1e-142 hypothetical protein YQE_08530, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 1323 2.0e-144 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF15886//PF00722 Carbohydrate binding domain (family 32)//Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0030246//GO:0004553 carbohydrate binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.35937 BP_3 123.00 20.85 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35938 BP_3 75.72 0.68 5620 826467549 XP_012535467.1 2089 2.1e-231 PREDICTED: glutamate dehydrogenase, mitochondrial [Monomorium pharaonis] 195573296 XM_002104594.1 246 4.54332e-123 Drosophila simulans GD18335 (Dsim\GD18335), mRNA K00261 GLUD1_2, gdhA glutamate dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00261 P54385 1924 1.2e-213 Glutamate dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=Gdh PE=1 SV=2 PF02812//PF00208//PF02826 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016491//GO:0051287 oxidoreductase activity//NAD binding -- -- KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases Cluster-8309.3594 BP_3 3.00 0.81 471 642914921 XP_972109.2 462 8.2e-44 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q93873 384 3.7e-36 Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Caenorhabditis elegans GN=gas-1 PE=3 SV=2 PF00346//PF00374 Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Nickel-dependent hydrogenase GO:0055114 oxidation-reduction process GO:0016651//GO:0048038//GO:0051287//GO:0016151 oxidoreductase activity, acting on NAD(P)H//quinone binding//NAD binding//nickel cation binding -- -- KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-8309.35943 BP_3 1722.83 28.76 3179 642936524 XP_008198472.1 3435 0.0e+00 PREDICTED: transmembrane GTPase Marf [Tribolium castaneum]>gi|642936526|ref|XP_970147.2| PREDICTED: transmembrane GTPase Marf [Tribolium castaneum] 462318797 APGK01044284.1 207 1.22392e-101 Dendroctonus ponderosae Seq01044294, whole genome shotgun sequence K06030 MFN mitofusin http://www.genome.jp/dbget-bin/www_bget?ko:K06030 Q7YU24 2272 3.0e-254 Transmembrane GTPase Marf OS=Drosophila melanogaster GN=Marf PE=1 SV=1 PF01926//PF04799//PF11734 50S ribosome-binding GTPase//fzo-like conserved region//TilS substrate C-terminal domain GO:0008053//GO:0008033 mitochondrial fusion//tRNA processing GO:0005524//GO:0003924//GO:0016879//GO:0000166//GO:0005525 ATP binding//GTPase activity//ligase activity, forming carbon-nitrogen bonds//nucleotide binding//GTP binding GO:0016021//GO:0005741//GO:0005737 integral component of membrane//mitochondrial outer membrane//cytoplasm KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis Cluster-8309.35944 BP_3 1856.60 87.28 1317 478260464 ENN80184.1 1226 5.9e-132 hypothetical protein YQE_03380, partial [Dendroctonus ponderosae]>gi|546674446|gb|ERL85820.1| hypothetical protein D910_03235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P301 681 3.8e-70 Protein YIF1B OS=Xenopus tropicalis GN=yif1b PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG3094 Predicted membrane protein Cluster-8309.35946 BP_3 926.00 49.14 1200 780654779 XP_011691311.1 188 1.2e-11 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X2 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- P22700 127 6.0e-06 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35948 BP_3 1593.97 17.82 4602 546675246 ERL86482.1 738 7.9e-75 hypothetical protein D910_03887 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305//PF08038 Protein of unknown function (DUF1049)//TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005887//GO:0005742 integral component of plasma membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.35949 BP_3 25.72 1.08 1437 91081621 XP_966892.1 986 4.3e-104 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54P77 593 6.6e-60 Probable 4-coumarate--CoA ligase 1 OS=Dictyostelium discoideum GN=4cl1 PE=3 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.35950 BP_3 692.52 20.06 1956 642936923 XP_970894.2 931 1.4e-97 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 Q94527 510 3.8e-50 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.35951 BP_3 753.19 27.48 1613 91084535 XP_972884.1 2160 3.6e-240 PREDICTED: NADH-ubiquinone oxidoreductase 49 kDa subunit [Tribolium castaneum]>gi|270009249|gb|EFA05697.1| hypothetical protein TcasGA2_TC015217 [Tribolium castaneum] 642925604 XM_967791.3 288 5.76767e-147 PREDICTED: Tribolium castaneum NADH-ubiquinone oxidoreductase 49 kDa subunit (LOC661641), mRNA K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q641Y2 1842 1.1e-204 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Rattus norvegicus GN=Ndufs2 PE=1 SV=1 PF00374//PF00165//PF00346 Nickel-dependent hydrogenase//Bacterial regulatory helix-turn-helix proteins, AraC family//Respiratory-chain NADH dehydrogenase, 49 Kd subunit GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0003700//GO:0048038//GO:0043565//GO:0016151//GO:0051287//GO:0016651 transcription factor activity, sequence-specific DNA binding//quinone binding//sequence-specific DNA binding//nickel cation binding//NAD binding//oxidoreductase activity, acting on NAD(P)H GO:0005667 transcription factor complex KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-8309.35952 BP_3 153.01 1.60 4900 478252421 ENN72845.1 503 1.5e-47 hypothetical protein YQE_10525, partial [Dendroctonus ponderosae]>gi|546677840|gb|ERL88597.1| hypothetical protein D910_05982 [Dendroctonus ponderosae] 642919574 XM_970177.2 87 9.66128e-35 PREDICTED: Tribolium castaneum calcineurin subunit B type 2 (LOC664163), mRNA K06268 PPP3R, CNB serine/threonine-protein phosphatase 2B regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06268 P48451 487 4.4e-47 Calcineurin subunit B type 1 OS=Drosophila melanogaster GN=CanB PE=2 SV=1 PF12763//PF13202//PF13499//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.35953 BP_3 115.00 0.93 6232 270012501 EFA08949.1 830 2.3e-85 hypothetical protein TcasGA2_TC006656 [Tribolium castaneum] 642933042 XM_966204.3 206 8.67795e-101 PREDICTED: Tribolium castaneum neo-calmodulin-like (LOC659938), transcript variant X3, mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02595 566 3.9e-56 Calmodulin OS=Patinopecten sp. PE=1 SV=2 PF13405//PF10591//PF13833//PF13499//PF12763//PF03874//PF08785//PF00036//PF13202 EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//RNA polymerase Rpb4//Ku C terminal domain like//EF hand//EF hand GO:0006351//GO:0007165//GO:0006144//GO:0006206 transcription, DNA-templated//signal transduction//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0005515//GO:0005509//GO:0016817 DNA-directed RNA polymerase activity//protein binding//calcium ion binding//hydrolase activity, acting on acid anhydrides GO:0005578//GO:0005730 proteinaceous extracellular matrix//nucleolus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35954 BP_3 216.75 11.87 1172 91084833 XP_966469.1 1262 3.5e-136 PREDICTED: inositol oxygenase [Tribolium castaneum]>gi|270008967|gb|EFA05415.1| hypothetical protein TcasGA2_TC015591 [Tribolium castaneum] -- -- -- -- -- K00469 MIOX inositol oxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00469 Q4V8T0 885 7.5e-94 Inositol oxygenase OS=Danio rerio GN=miox PE=2 SV=1 PF16622//PF01075//PF05153 zinc-finger C2H2-type//Glycosyltransferase family 9 (heptosyltransferase)//Myo-inositol oxygenase GO:0008152//GO:0019310//GO:0055114 metabolic process//inositol catabolic process//oxidation-reduction process GO:0016757//GO:0050113//GO:0046872//GO:0005506 transferase activity, transferring glycosyl groups//inositol oxygenase activity//metal ion binding//iron ion binding GO:0005737 cytoplasm KOG1573 Aldehyde reductase Cluster-8309.35957 BP_3 960.69 20.44 2557 91090780 XP_966783.1 2496 6.2e-279 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [Tribolium castaneum]>gi|642935900|ref|XP_008198220.1| PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [Tribolium castaneum]>gi|642935902|ref|XP_008198221.1| PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [Tribolium castaneum] 170066649 XM_001868153.1 669 0 Culex quinquefasciatus calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2387 1.1e-267 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.35961 BP_3 6988.79 221.87 1810 91094775 XP_968026.1 520 5.9e-50 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9I1 145 7.4e-08 Cyclin-G1 OS=Bos taurus GN=CCNG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35962 BP_3 18.00 0.49 2075 332373698 AEE61990.1 1569 1.6e-171 unknown [Dendroctonus ponderosae] 665399649 NM_165636.2 147 1.7947e-68 Drosophila melanogaster phosphoglucose isomerase (Pgi), transcript variant C, mRNA K01810 GPI, pgi glucose-6-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01810 P52031 1358 1.9e-148 Glucose-6-phosphate isomerase OS=Drosophila yakuba GN=Pgi PE=3 SV=1 PF00342//PF02792 Phosphoglucose isomerase//Mago nashi protein GO:0005985//GO:0006094//GO:0006096//GO:0005982//GO:0006098 sucrose metabolic process//gluconeogenesis//glycolytic process//starch metabolic process//pentose-phosphate shunt GO:0004347 glucose-6-phosphate isomerase activity GO:0005634 nucleus KOG2446 Glucose-6-phosphate isomerase Cluster-8309.35963 BP_3 10502.00 550.65 1211 283046836 NP_001164361.1 1692 5.0e-186 ATP synthase subunit beta, mitochondrial [Tribolium castaneum]>gi|270009266|gb|EFA05714.1| hypothetical protein TcasGA2_TC015322 [Tribolium castaneum] 332375359 BT127859.1 593 0 Dendroctonus ponderosae clone DPO123_G12 unknown mRNA K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q05825 1552 3.5e-171 ATP synthase subunit beta, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-beta PE=1 SV=3 PF00006//PF01637//PF03193//PF00005//PF00931//PF02874 ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//NB-ARC domain//ATP synthase alpha/beta family, beta-barrel domain GO:0015991//GO:0046034//GO:0006119//GO:0015992//GO:0015986 ATP hydrolysis coupled proton transport//ATP metabolic process//oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0003924//GO:0043531//GO:0005524//GO:0008553//GO:0046933//GO:0016887//GO:0005525 GTPase activity//ADP binding//ATP binding//hydrogen-exporting ATPase activity, phosphorylative mechanism//proton-transporting ATP synthase activity, rotational mechanism//ATPase activity//GTP binding GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1350 F0F1-type ATP synthase, beta subunit Cluster-8309.35965 BP_3 1658.96 15.77 5363 642930795 XP_008196094.1 4761 0.0e+00 PREDICTED: tight junction protein ZO-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05701 TJP1, ZO1 tight junction protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05701 Q9UDY2 891 6.9e-94 Tight junction protein ZO-2 OS=Homo sapiens GN=TJP2 PE=1 SV=2 PF00018//PF00595//PF13180 SH3 domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3580 Tight junction proteins Cluster-8309.35966 BP_3 2887.60 27.72 5312 642924642 XP_008194376.1 4558 0.0e+00 PREDICTED: tensin isoform X2 [Tribolium castaneum] 642924641 XM_008196154.1 194 3.46237e-94 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X2, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 818 2.0e-85 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.35968 BP_3 27901.69 245.08 5779 570341960 AHE77377.1 2740 7.1e-307 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 905 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2669 5.0e-300 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF01223//PF06723//PF04625//PF00033//PF01194//PF02491//PF01370//PF01968//PF02782//PF08303//PF00106//PF01073//PF05739 DNA/RNA non-specific endonuclease//MreB/Mbl protein//DEC-1 protein, N-terminal region//Cytochrome b/b6/petB//RNA polymerases N / 8 kDa subunit//SHS2 domain inserted in FTSA//NAD dependent epimerase/dehydratase family//Hydantoinase/oxoprolinase//FGGY family of carbohydrate kinases, C-terminal domain//tRNA ligase kinase domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//SNARE domain GO:0008210//GO:0008152//GO:0006388//GO:0022904//GO:0005975//GO:0055114//GO:0000902//GO:0008207//GO:0006144//GO:0006351//GO:0006206//GO:0007049//GO:0007304//GO:0006694//GO:0008209 estrogen metabolic process//metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain//carbohydrate metabolic process//oxidation-reduction process//cell morphogenesis//C21-steroid hormone metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//cell cycle//chorion-containing eggshell formation//steroid biosynthetic process//androgen metabolic process GO:0016491//GO:0046872//GO:0003676//GO:0016773//GO:0016616//GO:0003854//GO:0005524//GO:0005515//GO:0003677//GO:0003824//GO:0003972//GO:0016787//GO:0003899//GO:0050662//GO:0005213 oxidoreductase activity//metal ion binding//nucleic acid binding//phosphotransferase activity, alcohol group as acceptor//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//ATP binding//protein binding//DNA binding//catalytic activity//RNA ligase (ATP) activity//hydrolase activity//DNA-directed RNA polymerase activity//coenzyme binding//structural constituent of chorion GO:0005730//GO:0016020//GO:0005576//GO:0042600 nucleolus//membrane//extracellular region//chorion KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.35970 BP_3 4908.91 121.20 2244 8648961 CAB94834.1 2279 7.9e-254 eukaryotic translation initiation factor 2 gamma [Leptinotarsa decemlineata] 8648960 AJ290964.1 484 0 Leptinotarsa decemlineata mRNA for eukaryotic translation initiation factor 2 gamma (eIF-2g gene) K03242 EIF2S3 translation initiation factor 2 subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03242 Q5ZMS3 2027 5.4e-226 Eukaryotic translation initiation factor 2 subunit 3 OS=Gallus gallus GN=EIF2S3 PE=1 SV=1 PF03193//PF03144//PF01926 Protein of unknown function, DUF258//Elongation factor Tu domain 2//50S ribosome-binding GTPase -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Cluster-8309.35972 BP_3 7117.89 67.53 5372 699049757 AIU39233.1 850 9.5e-88 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 669 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 793 1.6e-82 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF10186//PF16326//PF04111//PF06009//PF00435//PF03577//PF02601//PF08702//PF01105//PF07926//PF10473//PF06160//PF05739 Vacuolar sorting 38 and autophagy-related subunit 14//ABC transporter C-terminal domain//Autophagy protein Apg6//Laminin Domain II//Spectrin repeat//Peptidase family C69//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//SNARE domain GO:0000921//GO:0006308//GO:0006508//GO:0030168//GO:0007155//GO:0006810//GO:0006914//GO:0051258//GO:0007165//GO:0010508//GO:0006606 septin ring assembly//DNA catabolic process//proteolysis//platelet activation//cell adhesion//transport//autophagy//protein polymerization//signal transduction//positive regulation of autophagy//protein import into nucleus GO:0005515//GO:0008855//GO:0003677//GO:0030674//GO:0042803//GO:0045502//GO:0008134//GO:0016805//GO:0005102 protein binding//exodeoxyribonuclease VII activity//DNA binding//protein binding, bridging//protein homodimerization activity//dynein binding//transcription factor binding//dipeptidase activity//receptor binding GO:0005667//GO:0030286//GO:0005940//GO:0016021//GO:0005577//GO:0009318 transcription factor complex//dynein complex//septin ring//integral component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.35974 BP_3 128.18 3.90 1876 642912447 XP_008200864.1 229 3.4e-16 PREDICTED: LOW QUALITY PROTEIN: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35975 BP_3 663.19 10.71 3275 546682278 ERL92239.1 2238 6.6e-249 hypothetical protein D910_09556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 245 3.4e-19 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF00452 Apoptosis regulator proteins, Bcl-2 family GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.35978 BP_3 14098.00 96.15 7359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35979 BP_3 1487.82 19.04 4058 642935930 XP_008198233.1 4627 0.0e+00 PREDICTED: RRP12-like protein [Tribolium castaneum] 462473101 APGK01001802.1 98 6.13221e-41 Dendroctonus ponderosae Seq01001802, whole genome shotgun sequence K14794 RRP12 ribosomal RNA-processing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14794 Q5ZKD5 1918 4.3e-213 RRP12-like protein OS=Gallus gallus GN=RRP12 PE=2 SV=1 PF16782//PF01113//PF00552 Nucleotide exchange factor SIL1//Dihydrodipicolinate reductase, N-terminus//Integrase DNA binding domain GO:0055114//GO:0009085//GO:0009089 oxidation-reduction process//lysine biosynthetic process//lysine biosynthetic process via diaminopimelate GO:0008839//GO:0000774//GO:0003676 4-hydroxy-tetrahydrodipicolinate reductase//adenyl-nucleotide exchange factor activity//nucleic acid binding GO:0005783 endoplasmic reticulum KOG1248 Uncharacterized conserved protein Cluster-8309.35981 BP_3 10417.58 85.93 6135 478263045 ENN81445.1 762 1.7e-77 hypothetical protein YQE_02138, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A6QPN6 236 7.1e-18 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.35985 BP_3 6575.00 352.02 1192 642923500 XP_008193535.1 419 2.0e-38 PREDICTED: flocculation protein FLO11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35986 BP_3 48.16 1.20 2224 546679409 ERL89880.1 1808 3.2e-199 hypothetical protein D910_07239 [Dendroctonus ponderosae] -- -- -- -- -- K01587 PAICS phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01587 Q9I7S8 1473 9.3e-162 Multifunctional protein ADE2 OS=Drosophila melanogaster GN=ade5 PE=2 SV=2 PF00731//PF00763 AIR carboxylase//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0055114//GO:0046487//GO:0009396//GO:0006189 oxidation-reduction process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//'de novo' IMP biosynthetic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase Cluster-8309.35987 BP_3 1167.58 3.05 18725 612342210 AHW99830.1 19163 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1380 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 16243 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF01365//PF00622//PF13499//PF13833//PF02815//PF00520//PF06459//PF00487//PF06423 RIH domain//SPRY domain//EF-hand domain pair//EF-hand domain pair//MIR domain//Ion transport protein//Ryanodine Receptor TM 4-6//Fatty acid desaturase//GWT1 GO:0006816//GO:0055085//GO:0070588//GO:0006874//GO:0006629//GO:0006506//GO:0006811 calcium ion transport//transmembrane transport//calcium ion transmembrane transport//cellular calcium ion homeostasis//lipid metabolic process//GPI anchor biosynthetic process//ion transport GO:0005216//GO:0005262//GO:0005515//GO:0005219//GO:0016746//GO:0005509 ion channel activity//calcium channel activity//protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium ion binding GO:0016021//GO:0005622//GO:0005789//GO:0016020 integral component of membrane//intracellular//endoplasmic reticulum membrane//membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.35988 BP_3 189.64 3.85 2665 478257738 ENN77881.1 468 9.3e-44 hypothetical protein YQE_05559, partial [Dendroctonus ponderosae]>gi|546677678|gb|ERL88472.1| hypothetical protein D910_05858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7E3W5 255 1.9e-20 Synaptogyrin-2 OS=Bos taurus GN=SYNGR2 PE=2 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.35989 BP_3 571.42 11.90 2606 642916614 XP_008191899.1 1314 7.3e-142 PREDICTED: LOW QUALITY PROTEIN: suppressor of cytokine signaling 5 [Tribolium castaneum] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 3.2e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.3599 BP_3 9.84 0.51 1227 642911268 XP_972818.2 829 5.9e-86 PREDICTED: NAD-dependent protein deacylase [Tribolium castaneum] -- -- -- -- -- K11415 SIRT5, SIR2L5 NAD-dependent deacetylase sirtuin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11415 E9GD30 562 2.2e-56 NAD-dependent protein deacylase OS=Daphnia pulex GN=DAPPUDRAFT_195469 PE=3 SV=1 PF02146 Sir2 family -- -- GO:0070403 NAD+ binding -- -- KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family) Cluster-8309.35991 BP_3 54.90 0.92 3179 546679851 ERL90239.1 1019 1.4e-107 hypothetical protein D910_07592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83548 607 3.5e-61 Vanin-like protein 3 OS=Drosophila melanogaster GN=CG32750 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.35992 BP_3 16.34 0.42 2158 195401458 XP_002059330.1 1288 6.2e-139 GJ17887 [Drosophila virilis]>gi|194142336|gb|EDW58742.1| GJ17887 [Drosophila virilis] 299152231 HM156717.1 565 0 Laccophilus pictus voucher BT0073 elongation factor 1-alpha (EF1a) gene, partial cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P29520 1275 8.2e-139 Elongation factor 1-alpha OS=Bombyx mori PE=2 SV=1 PF02774//PF02615//PF03144//PF01926//PF00503//PF04670 Semialdehyde dehydrogenase, dimerisation domain//Malate/L-lactate dehydrogenase//Elongation factor Tu domain 2//50S ribosome-binding GTPase//G-protein alpha subunit//Gtr1/RagA G protein conserved region GO:0055114//GO:0007186//GO:0006448//GO:0000051//GO:0006414//GO:0007165//GO:0008652//GO:0006184//GO:0008152 oxidation-reduction process//G-protein coupled receptor signaling pathway//regulation of translational elongation//obsolete urea cycle intermediate metabolic process//translational elongation//signal transduction//cellular amino acid biosynthetic process//obsolete GTP catabolic process//metabolic process GO:0016620//GO:0019001//GO:0003924//GO:0031683//GO:0005525//GO:0003942//GO:0003746//GO:0004871//GO:0046983//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//guanyl nucleotide binding//GTPase activity//G-protein beta/gamma-subunit complex binding//GTP binding//N-acetyl-gamma-glutamyl-phosphate reductase activity//translation elongation factor activity//signal transducer activity//protein dimerization activity//oxidoreductase activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.35993 BP_3 1328.38 15.49 4426 478260090 ENN79875.1 3508 0.0e+00 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 6.98351e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 3027 0.0e+00 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006094//GO:0006013//GO:0006000//GO:0006096//GO:0006098//GO:0006012 gluconeogenesis//mannose metabolic process//fructose metabolic process//glycolytic process//pentose-phosphate shunt//galactose metabolic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.35995 BP_3 1146.41 4.54 12451 270006541 EFA02989.1 7377 0.0e+00 hypothetical protein TcasGA2_TC010408 [Tribolium castaneum] 642922985 XM_008202260.1 727 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase TRIP12 (LOC658915), transcript variant X4, mRNA K10590 TRIP12 E3 ubiquitin-protein ligase TRIP12 http://www.genome.jp/dbget-bin/www_bget?ko:K10590 F1LP64 4376 0.0e+00 E3 ubiquitin-protein ligase TRIP12 OS=Rattus norvegicus GN=Trip12 PE=2 SV=1 PF00515//PF13374//PF13371//PF13414//PF13176//PF12470//PF13181//PF13174//PF00632//PF00514//PF04049 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Suppressor of Fused Gli/Ci N terminal binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//HECT-domain (ubiquitin-transferase)//Armadillo/beta-catenin-like repeat//Anaphase promoting complex subunit 8 / Cdc23 GO:0016567//GO:0030071 protein ubiquitination//regulation of mitotic metaphase/anaphase transition GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0170 E3 ubiquitin protein ligase Cluster-8309.35996 BP_3 5585.25 186.01 1739 189236526 XP_975464.2 2521 5.3e-282 PREDICTED: spondin-1 [Tribolium castaneum]>gi|270005305|gb|EFA01753.1| hypothetical protein TcasGA2_TC007351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 738 1.2e-76 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.35998 BP_3 3952.80 51.71 3976 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF00983//PF01926//PF03144//PF03764 Tymovirus coat protein//50S ribosome-binding GTPase//Elongation factor Tu domain 2//Elongation factor G, domain IV -- -- GO:0005525//GO:0005198 GTP binding//structural molecule activity GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.35999 BP_3 184.52 6.64 1631 332374148 AEE62215.1 1067 2.0e-113 unknown [Dendroctonus ponderosae]>gi|546676817|gb|ERL87763.1| hypothetical protein D910_05152 [Dendroctonus ponderosae] -- -- -- -- -- K17885 MTCH mitochondrial carrier http://www.genome.jp/dbget-bin/www_bget?ko:K17885 Q791V5 591 1.3e-59 Mitochondrial carrier homolog 2 OS=Mus musculus GN=Mtch2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2745 Mitochondrial carrier protein Cluster-8309.360 BP_3 4.00 0.51 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3600 BP_3 61.59 3.36 1176 642911268 XP_972818.2 857 3.2e-89 PREDICTED: NAD-dependent protein deacylase [Tribolium castaneum] -- -- -- -- -- K11415 SIRT5, SIR2L5 NAD-dependent deacetylase sirtuin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11415 E9GD30 590 1.2e-59 NAD-dependent protein deacylase OS=Daphnia pulex GN=DAPPUDRAFT_195469 PE=3 SV=1 PF02146 Sir2 family -- -- GO:0070403 NAD+ binding -- -- KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family) Cluster-8309.36000 BP_3 295.42 9.76 1751 270009420 EFA05868.1 1905 1.4e-210 hypothetical protein TcasGA2_TC008668 [Tribolium castaneum] 642930354 XM_008198140.1 495 0 PREDICTED: Tribolium castaneum protein 4.1 homolog (LOC662229), transcript variant X4, mRNA K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1380 4.5e-151 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36001 BP_3 551.00 20.94 1560 642929259 XP_008195758.1 895 1.7e-93 PREDICTED: translin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62348 616 1.5e-62 Translin OS=Mus musculus GN=Tsn PE=1 SV=1 PF08988//PF01997 Type III secretion system, cytoplasmic E component of needle//Translin family GO:0009405 pathogenesis GO:0043565 sequence-specific DNA binding -- -- KOG3067 Translin family protein Cluster-8309.36002 BP_3 893.76 18.97 2563 549438519 AGX25148.1 2765 4.0e-310 beta-glucuronidase-like protein [Leptinotarsa decemlineata] 195400569 XM_002058853.1 36 1.12641e-06 Drosophila virilis GJ19669 (Dvir\GJ19669), mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P08236 1387 1.0e-151 Beta-glucuronidase OS=Homo sapiens GN=GUSB PE=1 SV=2 PF02836//PF00703//PF02837 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.36005 BP_3 240.23 6.60 2047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965//PF15048 dsRNA-gated channel SID-1//Organic solute transporter subunit beta protein GO:0033227//GO:0015931//GO:0006810//GO:0015721 dsRNA transport//nucleobase-containing compound transport//transport//bile acid and bile salt transport GO:0051033//GO:0046982//GO:0005215 RNA transmembrane transporter activity//protein heterodimerization activity//transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.36006 BP_3 487.04 35.99 944 642936964 XP_008198631.1 1380 5.8e-150 PREDICTED: rab GTPase-activating protein 1-like isoform X2 [Tribolium castaneum]>gi|270001031|gb|EEZ97478.1| hypothetical protein TcasGA2_TC011312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RAN1 870 3.3e-92 Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.36009 BP_3 24.50 7.73 444 530723035 AGT42326.1 598 1.3e-59 cardiac muscle actin [Portunus trituberculatus] 530723034 KC131029.1 258 7.14358e-131 Portunus trituberculatus cardiac muscle actin mRNA, complete cds K12315 ACTG2 actin, gamma-enteric smooth muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12315 P63268 572 5.6e-58 Actin, gamma-enteric smooth muscle OS=Mus musculus GN=Actg2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.36010 BP_3 636.77 3.95 8064 546673207 ERL84861.1 1263 1.8e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.1e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF00503//PF03824//PF01166//PF06005//PF04111//PF06156//PF15458//PF17078//PF04548//PF02183//PF03193//PF00005//PF07989//PF00437//PF01066//PF05529//PF04632 G-protein alpha subunit//High-affinity nickel-transport protein//TSC-22/dip/bun family//Protein of unknown function (DUF904)//Autophagy protein Apg6//Protein of unknown function (DUF972)//Nineteen complex-related protein 2//SWI5-dependent HO expression protein 3//AIG1 family//Homeobox associated leucine zipper//Protein of unknown function, DUF258//ABC transporter//Centrosomin N-terminal motif 1//Type II/IV secretion system protein//CDP-alcohol phosphatidyltransferase//B-cell receptor-associated protein 31-like//Fusaric acid resistance protein family GO:0007165//GO:0006914//GO:0006810//GO:0006886//GO:0006355//GO:0007186//GO:0000390//GO:0015675//GO:0043093//GO:0008654//GO:0000917//GO:0035444//GO:0006260//GO:0051028//GO:0048309 signal transduction//autophagy//transport//intracellular protein transport//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway//spliceosomal complex disassembly//nickel cation transport//FtsZ-dependent cytokinesis//phospholipid biosynthetic process//barrier septum assembly//nickel cation transmembrane transport//DNA replication//mRNA transport//endoplasmic reticulum inheritance GO:0043565//GO:0016780//GO:0005525//GO:0015099//GO:0004871//GO:0005524//GO:0031683//GO:0003924//GO:0019001//GO:0016887//GO:0003700//GO:0046872 sequence-specific DNA binding//phosphotransferase activity, for other substituted phosphate groups//GTP binding//nickel cation transmembrane transporter activity//signal transducer activity//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//guanyl nucleotide binding//ATPase activity//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0016021//GO:0005815//GO:0005737//GO:0005886//GO:0005783//GO:0016020//GO:0071008//GO:0005667 integral component of membrane//microtubule organizing center//cytoplasm//plasma membrane//endoplasmic reticulum//membrane//U2-type post-mRNA release spliceosomal complex//transcription factor complex KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.36013 BP_3 92.08 0.99 4787 91091728 XP_967315.1 1405 3.7e-152 PREDICTED: argininosuccinate synthase [Tribolium castaneum]>gi|270001069|gb|EEZ97516.1| hypothetical protein TcasGA2_TC011361 [Tribolium castaneum] 78496741 CP000153.1 36 2.11626e-06 Sulfurimonas denitrificans DSM 1251, complete genome K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 Q0IFL5 1165 1.0e-125 Argininosuccinate synthase OS=Aedes aegypti GN=AAEL004701 PE=3 SV=1 PF00764//PF00498 Arginosuccinate synthase//FHA domain GO:0006522//GO:0006526//GO:0006560//GO:0006531 alanine metabolic process//arginine biosynthetic process//proline metabolic process//aspartate metabolic process GO:0005524//GO:0005515//GO:0004055 ATP binding//protein binding//argininosuccinate synthase activity -- -- KOG1706 Argininosuccinate synthase Cluster-8309.36014 BP_3 2382.54 74.65 1830 546683575 ERL93373.1 1505 3.6e-164 hypothetical protein D910_10665 [Dendroctonus ponderosae] 642921542 XM_970634.3 225 6.89389e-112 PREDICTED: Tribolium castaneum uncharacterized LOC655573 (LOC655573), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36015 BP_3 3486.28 33.88 5251 557211143 CDJ50285.1 179 6.0e-10 hypothetical protein EBH_0032330 [Eimeria brunetti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00977 Histidine biosynthesis protein GO:0000105 histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.36019 BP_3 2772.75 68.46 2244 91095131 XP_971500.1 1627 3.2e-178 PREDICTED: transforming growth factor-beta-induced protein ig-h3 [Tribolium castaneum]>gi|270015611|gb|EFA12059.1| hypothetical protein TcasGA2_TC012903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15063 425 3.1e-40 Periostin OS=Homo sapiens GN=POSTN PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.36020 BP_3 1523.30 21.55 3699 642913015 XP_008201353.1 4683 0.0e+00 PREDICTED: spectrin alpha chain [Tribolium castaneum]>gi|270002786|gb|EEZ99233.1| alpha spectrin [Tribolium castaneum] 158296318 XM_316724.4 961 0 Anopheles gambiae str. PEST AGAP006686-PA (AgaP_AGAP006686) mRNA, complete cds K06114 SPTA spectrin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06114 P13395 4249 0.0e+00 Spectrin alpha chain OS=Drosophila melanogaster GN=alpha-Spec PE=1 SV=2 PF00435 Spectrin repeat -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36022 BP_3 1822.71 11.82 7723 642938555 XP_008199840.1 3532 0.0e+00 PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum]>gi|642938557|ref|XP_008199841.1| PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum] 642938563 XM_963618.3 697 0 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X6, mRNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 6.3e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF02985//PF09258//PF01312//PF01602//PF00514 HEAT repeat//Glycosyl transferase family 64 domain//FlhB HrpN YscU SpaS Family//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0015012//GO:0006024//GO:0009306//GO:0016192//GO:0006886 heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process//protein secretion//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0016020//GO:0030117//GO:0016021 membrane//membrane coat//integral component of membrane KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins Cluster-8309.36024 BP_3 209.64 32.77 600 642915081 XP_008190403.1 488 1.0e-46 PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|642915083|ref|XP_008190404.1| PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|270002357|gb|EEZ98804.1| hypothetical protein TcasGA2_TC001374 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q23808 295 9.9e-26 Aquaporin AQPcic OS=Cicadella viridis GN=AQP PE=1 SV=1 PF00230//PF17070 Major intrinsic protein//30S ribosomal protein Thx GO:0006810 transport GO:0005215 transporter activity GO:0005840//GO:0016020 ribosome//membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.36025 BP_3 24.69 1.23 1258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36026 BP_3 195.00 4.32 2467 642929374 XP_008195808.1 778 9.8e-80 PREDICTED: rho GTPase-activating protein 11A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P4F7 259 6.1e-21 Rho GTPase-activating protein 11A OS=Homo sapiens GN=ARHGAP11A PE=1 SV=2 PF11365//PF05445//PF01736//PF00620 Protein of unknown function (DUF3166)//Poxvirus serine/threonine protein kinase//Polyomavirus agnoprotein//RhoGAP domain GO:0010506//GO:0007165 regulation of autophagy//signal transduction GO:0004672//GO:0005524//GO:0003677 protein kinase activity//ATP binding//DNA binding GO:0005615 extracellular space -- -- Cluster-8309.36027 BP_3 10846.97 186.83 3090 91090103 XP_970810.1 1785 2.1e-196 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 160947857 EU258622.1 288 1.1159e-146 Spodoptera exigua ribosomal protein L10 (RpL10) mRNA, complete cds K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O96647 1088 5.7e-117 60S ribosomal protein L10 OS=Bombyx mandarina GN=RpL10 PE=2 SV=1 PF14634//PF00252//PF13639 zinc-RING finger domain//Ribosomal protein L16p/L10e//Ring finger domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0046872//GO:0008270//GO:0003735 protein binding//metal ion binding//zinc ion binding//structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.36028 BP_3 16583.83 951.28 1132 264667425 ACY71298.1 1234 6.0e-133 ribosomal protein L8 [Chrysomela tremula] 401828841 JX122920.1 415 0 Phaedon cochleariae ribosomal protein L8 mRNA, partial cds K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q6RYS3 1160 9.4e-126 60S ribosomal protein L8 OS=Mamestra brassicae GN=RpL8 PE=2 SV=1 PF03947//PF00181 Ribosomal Proteins L2, C-terminal domain//Ribosomal Proteins L2, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2309 60s ribosomal protein L2/L8 Cluster-8309.36029 BP_3 131.06 0.90 7278 589060792 AHK26789.1 2872 0.0e+00 pyruvate carboxylase, partial [Epicauta chinensis] 817070062 XM_012401613.1 189 2.85901e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 2262 9.9e-253 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF05896//PF00682//PF07478//PF02786//PF02655 Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//HMGL-like//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//ATP-grasp domain GO:0046436//GO:0055114//GO:0009252//GO:0006814//GO:0006118 D-alanine metabolic process//oxidation-reduction process//peptidoglycan biosynthetic process//sodium ion transport//obsolete electron transport GO:0005524//GO:0003824//GO:0008716//GO:0016655//GO:0046872 ATP binding//catalytic activity//D-alanine-D-alanine ligase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//metal ion binding -- -- KOG0369 Pyruvate carboxylase Cluster-8309.3603 BP_3 1.00 0.36 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36030 BP_3 1391.97 22.72 3245 91090103 XP_970810.1 1889 1.9e-208 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 160947857 EU258622.1 288 1.17254e-146 Spodoptera exigua ribosomal protein L10 (RpL10) mRNA, complete cds -- -- -- -- O96647 1088 6.0e-117 60S ribosomal protein L10 OS=Bombyx mandarina GN=RpL10 PE=2 SV=1 PF03854//PF14634//PF00252//PF13639 P-11 zinc finger//zinc-RING finger domain//Ribosomal protein L16p/L10e//Ring finger domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0005515//GO:0008270//GO:0003735//GO:0046872 RNA binding//protein binding//zinc ion binding//structural constituent of ribosome//metal ion binding GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.36033 BP_3 94.89 10.68 720 642914311 XP_008201630.1 567 8.4e-56 PREDICTED: mimitin, mitochondrial [Tribolium castaneum]>gi|270002195|gb|EEZ98642.1| hypothetical protein TcasGA2_TC001170 [Tribolium castaneum] -- -- -- -- -- K18160 NDUFAF2 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18160 Q32P65 147 1.7e-08 Mimitin, mitochondrial OS=Bos taurus GN=NDUFAF2 PE=2 SV=1 PF01907//PF05071 Ribosomal protein L37e//NADH ubiquinone oxidoreductase subunit NDUFA12 GO:0006412//GO:0006120//GO:0042254//GO:0015992//GO:0006814//GO:0006118//GO:0006744 translation//mitochondrial electron transport, NADH to ubiquinone//ribosome biogenesis//proton transport//sodium ion transport//obsolete electron transport//ubiquinone biosynthetic process GO:0008137//GO:0003735//GO:0009055 NADH dehydrogenase (ubiquinone) activity//structural constituent of ribosome//electron carrier activity GO:0005840//GO:0005622//GO:0016020 ribosome//intracellular//membrane -- -- Cluster-8309.36035 BP_3 68243.61 1292.82 2836 642911248 XP_008199756.1 2946 0.0e+00 PREDICTED: polyadenylate-binding protein 1 isoform X1 [Tribolium castaneum] 642911247 XM_008201534.1 595 0 PREDICTED: Tribolium castaneum polyadenylate-binding protein 1 (LOC657776), transcript variant X1, mRNA K13126 PABPC polyadenylate-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13126 P29341 2137 1.2e-238 Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2 PF16367//PF00658//PF00076 RNA recognition motif//Poly-adenylate binding protein, unique domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-8309.36036 BP_3 163.20 2.96 2945 270002097 EEZ98544.1 638 2.0e-63 hypothetical protein TcasGA2_TC001048 [Tribolium castaneum] 642913817 XM_008202950.1 224 4.01702e-111 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 450 5.2e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13405//PF12558//PF13499 EF-hand domain//ATP-binding cassette cobalt transporter//EF-hand domain pair -- -- GO:0005509//GO:0016820 calcium ion binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.36037 BP_3 39.72 0.45 4508 270011248 EFA07696.1 495 1.2e-46 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI85 213 2.4e-15 Smoothelin-like protein 2 OS=Bos taurus GN=SMTNL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.36038 BP_3 1055.12 49.51 1319 91088775 XP_967272.1 1008 1.1e-106 PREDICTED: peptide methionine sulfoxide reductase [Tribolium castaneum]>gi|270011632|gb|EFA08080.1| hypothetical protein TcasGA2_TC005676 [Tribolium castaneum] -- -- -- -- -- K07304 msrA peptide-methionine (S)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07304 P08761 637 4.8e-65 Peptide methionine sulfoxide reductase OS=Drosophila melanogaster GN=Eip71CD PE=2 SV=2 PF01625 Peptide methionine sulfoxide reductase GO:0055114//GO:0006464 oxidation-reduction process//cellular protein modification process GO:0008113 peptide-methionine (S)-S-oxide reductase activity -- -- KOG1635 Peptide methionine sulfoxide reductase Cluster-8309.36039 BP_3 442.53 12.85 1952 91085253 XP_973335.1 1079 9.7e-115 PREDICTED: uncharacterized protein LOC662125 [Tribolium castaneum]>gi|270009097|gb|EFA05545.1| hypothetical protein TcasGA2_TC015733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00584 SecE/Sec61-gamma subunits of protein translocation complex GO:0006605//GO:0006886 protein targeting//intracellular protein transport -- -- GO:0016020 membrane -- -- Cluster-8309.36042 BP_3 458.00 18.00 1518 91079502 XP_969250.1 864 6.4e-90 PREDICTED: uncharacterized protein LOC657715 isoform X1 [Tribolium castaneum]>gi|270004422|gb|EFA00870.1| hypothetical protein TcasGA2_TC003773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KY0 126 1.0e-05 Apolipoprotein D OS=Bos taurus GN=APOD PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36044 BP_3 866.54 15.34 3014 820805526 AKG92754.1 921 3.1e-96 usf [Leptinotarsa decemlineata] 820805525 KP147917.1 174 2.56408e-83 Leptinotarsa decemlineata usf mRNA, complete cds K12191 CHMP2A charged multivesicular body protein 2A http://www.genome.jp/dbget-bin/www_bget?ko:K12191 Q6DFS6 458 6.3e-44 Charged multivesicular body protein 2a OS=Xenopus tropicalis GN=chmp2a PE=2 SV=1 PF06156//PF05615//PF01346//PF06729//PF03357//PF00010//PF05848//PF04152//PF04420 Protein of unknown function (DUF972)//Tho complex subunit 7//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Kinetochore component, CENP-R//Snf7//Helix-loop-helix DNA-binding domain//Firmicute transcriptional repressor of class III stress genes (CtsR)//Mre11 DNA-binding presumed domain//CHD5-like protein GO:0006950//GO:0006397//GO:0006457//GO:0034080//GO:0071816//GO:0006355//GO:0006260//GO:0007034//GO:0006302 response to stress//mRNA processing//protein folding//CENP-A containing nucleosome assembly//tail-anchored membrane protein insertion into ER membrane//regulation of transcription, DNA-templated//DNA replication//vacuolar transport//double-strand break repair GO:0004519//GO:0003677//GO:0046983//GO:0030145 endonuclease activity//DNA binding//protein dimerization activity//manganese ion binding GO:0005634//GO:0000445 nucleus//THO complex part of transcription export complex KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.36045 BP_3 46.74 0.40 5882 642932582 XP_008196911.1 6505 0.0e+00 PREDICTED: transcription elongation factor SPT6 isoform X1 [Tribolium castaneum]>gi|270011547|gb|EFA07995.1| hypothetical protein TcasGA2_TC005584 [Tribolium castaneum] 571562785 XM_006570424.1 121 1.46017e-53 PREDICTED: Apis mellifera transcription elongation factor SPT6-like (LOC410274), mRNA K11292 SUPT6H, SPT6 transcription elongation factor SPT6 http://www.genome.jp/dbget-bin/www_bget?ko:K11292 Q9W420 4218 0.0e+00 Transcription elongation factor SPT6 OS=Drosophila melanogaster GN=Spt6 PE=1 SV=1 PF00575//PF14641 S1 RNA binding domain//Helix-turn-helix DNA-binding domain of SPT6 GO:0032784//GO:0006357 regulation of DNA-templated transcription, elongation//regulation of transcription from RNA polymerase II promoter GO:0003677//GO:0003676//GO:0003723//GO:0016788 DNA binding//nucleic acid binding//RNA binding//hydrolase activity, acting on ester bonds -- -- KOG1856 Transcription elongation factor SPT6 Cluster-8309.36047 BP_3 1297.59 57.90 1372 270013371 EFA09819.1 970 3.0e-102 hypothetical protein TcasGA2_TC011965 [Tribolium castaneum] 780158183 XM_011684374.1 51 2.73274e-15 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 Q9VJE5 554 2.1e-55 Restin homolog OS=Drosophila melanogaster GN=CLIP-190 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36048 BP_3 300.14 9.01 1897 642913235 XP_008201450.1 758 1.6e-77 PREDICTED: uncharacterized protein LOC664170 isoform X3 [Tribolium castaneum] 642913234 XM_008203228.1 83 6.19077e-33 PREDICTED: Tribolium castaneum uncharacterized LOC664170 (LOC664170), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36049 BP_3 111.99 1.15 5002 642935312 XP_008197963.1 2029 1.7e-224 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 1.0147e-14 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1109 3.4e-119 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF10186//PF00038//PF08702 Vacuolar sorting 38 and autophagy-related subunit 14//Intermediate filament protein//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0010508//GO:0030168 protein polymerization//signal transduction//positive regulation of autophagy//platelet activation GO:0005198//GO:0030674//GO:0005102 structural molecule activity//protein binding, bridging//receptor binding GO:0005882//GO:0005577 intermediate filament//fibrinogen complex -- -- Cluster-8309.36050 BP_3 64.98 0.72 4619 642935312 XP_008197963.1 2170 7.1e-241 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 9.36442e-15 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1138 1.4e-122 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF10186//PF00038//PF08702 Vacuolar sorting 38 and autophagy-related subunit 14//Intermediate filament protein//Fibrinogen alpha/beta chain family GO:0030168//GO:0010508//GO:0007165//GO:0051258 platelet activation//positive regulation of autophagy//signal transduction//protein polymerization GO:0030674//GO:0005102//GO:0005198 protein binding, bridging//receptor binding//structural molecule activity GO:0005577//GO:0005882 fibrinogen complex//intermediate filament -- -- Cluster-8309.36051 BP_3 18.98 11.65 367 329762924 AEC04843.1 355 1.6e-31 chemosensory protein [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q9W1C9 292 1.4e-25 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF00649//PF02664 Copper fist DNA binding domain//S-Ribosylhomocysteinase (LuxS) GO:0006355//GO:0009372 regulation of transcription, DNA-templated//quorum sensing GO:0005506//GO:0003700//GO:0003677//GO:0005507//GO:0043768 iron ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding//copper ion binding//S-ribosylhomocysteine lyase activity GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36052 BP_3 811.34 10.58 3989 91090196 XP_967193.1 2643 8.7e-296 PREDICTED: cyclin-G-associated kinase [Tribolium castaneum]>gi|270013468|gb|EFA09916.1| hypothetical protein TcasGA2_TC012067 [Tribolium castaneum] -- -- -- -- -- K08855 GAK cyclin G-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08855 P97874 1662 2.0e-183 Cyclin-G-associated kinase OS=Rattus norvegicus GN=Gak PE=2 SV=1 PF00782//PF07714//PF00069 Dual specificity phosphatase, catalytic domain//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0006470//GO:0016310 protein phosphorylation//protein dephosphorylation//phosphorylation GO:0008138//GO:0004672//GO:0000166//GO:0005524 protein tyrosine/serine/threonine phosphatase activity//protein kinase activity//nucleotide binding//ATP binding -- -- KOG1989 ARK protein kinase family Cluster-8309.36053 BP_3 3947.65 27.42 7230 642917231 XP_008191173.1 2074 1.5e-229 PREDICTED: thioredoxin reductase 2, mitochondrial isoform X2 [Tribolium castaneum] 195396538 XM_002056853.1 42 1.47971e-09 Drosophila virilis GJ16646 (Dvir\GJ16646), mRNA K00384 trxB thioredoxin reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00384 P91938 1574 5.9e-173 Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 PE=1 SV=2 PF01296//PF02852//PF07992//PF01494//PF00106//PF12831//PF05699//PF01979//PF03435//PF01266//PF06268//PF00070//PF04369//PF02558//PF01134 Galanin//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//short chain dehydrogenase//FAD dependent oxidoreductase//hAT family C-terminal dimerisation region//Amidohydrolase family//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//Fascin domain//Pyridine nucleotide-disulphide oxidoreductase//Lactococcin-like family//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A GO:0008152//GO:0045454//GO:0007165//GO:0015940//GO:0042742//GO:0055114//GO:0008033 metabolic process//cell redox homeostasis//signal transduction//pantothenate biosynthetic process//defense response to bacterium//oxidation-reduction process//tRNA processing GO:0005179//GO:0046983//GO:0016491//GO:0030674//GO:0050660//GO:0008677//GO:0016787//GO:0071949//GO:0051015 hormone activity//protein dimerization activity//oxidoreductase activity//protein binding, bridging//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//hydrolase activity//FAD binding//actin filament binding GO:0005576 extracellular region KOG4716 Thioredoxin reductase Cluster-8309.36054 BP_3 5494.20 301.52 1170 546675310 ERL86538.1 247 1.7e-18 hypothetical protein D910_03944 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36055 BP_3 1152.44 35.31 1865 189237846 XP_974719.2 2264 3.6e-252 PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|642924610|ref|XP_008194362.1| PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|270007960|gb|EFA04408.1| hypothetical protein TcasGA2_TC014707 [Tribolium castaneum] 642924609 XM_008196140.1 369 0 PREDICTED: Tribolium castaneum BTB/POZ domain-containing protein 6 (LOC663586), transcript variant X2, mRNA -- -- -- -- F7ASZ0 357 2.0e-32 BTB/POZ domain-containing protein 3 OS=Callithrix jacchus GN=BTBD3 PE=2 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.36056 BP_3 180.64 4.05 2443 270001997 EEZ98444.1 975 1.4e-102 hypothetical protein TcasGA2_TC000933 [Tribolium castaneum] 459668605 JX303047.1 36 1.07295e-06 Lutzomyia longipalpis isolate PanupC10 up (up) gene, partial cds >gnl|BL_ORD_ID|16415056 Lutzomyia longipalpis isolate PanupH11 up (up) gene, partial cds K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 Q9XZ71 852 1.0e-89 Troponin T OS=Periplaneta americana GN=TNT PE=2 SV=1 PF00769//PF00992 Ezrin/radixin/moesin family//Troponin -- -- GO:0008092 cytoskeletal protein binding GO:0005737//GO:0005861//GO:0019898 cytoplasm//troponin complex//extrinsic component of membrane KOG3634 Troponin Cluster-8309.36057 BP_3 219.75 7.58 1690 642929787 XP_008195976.1 644 2.3e-64 PREDICTED: elongation of very long chain fatty acids protein AAEL008004-like [Tribolium castaneum]>gi|270009529|gb|EFA05977.1| hypothetical protein TcasGA2_TC008803 [Tribolium castaneum] -- -- -- -- -- K10249 ELOVL4 elongation of very long chain fatty acids protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10249 Q1HRV8 475 3.8e-46 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36059 BP_3 183.36 5.49 1902 91077370 XP_975175.1 898 9.2e-94 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001655|gb|EEZ98102.1| hypothetical protein TcasGA2_TC000515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28493 580 2.8e-58 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36060 BP_3 112.47 1.98 3028 282165790 NP_001164134.1 941 1.5e-98 drongo protein isoform 1 [Tribolium castaneum] -- -- -- -- -- K15044 AGFG1 Arf-GAP domain and FG repeats-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15044 P52594 415 6.1e-39 Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens GN=AGFG1 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0702 Predicted GTPase-activating protein Cluster-8309.36061 BP_3 112.73 14.36 670 642929699 XP_008195940.1 522 1.3e-50 PREDICTED: 28S ribosomal protein S18a, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02963 RP-S18, MRPS18, rpsR small subunit ribosomal protein S18 http://www.genome.jp/dbget-bin/www_bget?ko:K02963 Q9NVS2 176 7.0e-12 28S ribosomal protein S18a, mitochondrial OS=Homo sapiens GN=MRPS18A PE=1 SV=1 PF01084 Ribosomal protein S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3162 Mitochondrial/chloroplast ribosomal protein S18 Cluster-8309.36062 BP_3 1102.79 12.21 4645 478256677 ENN76859.1 1576 5.4e-172 hypothetical protein YQE_06700, partial [Dendroctonus ponderosae]>gi|546685126|gb|ERL94653.1| hypothetical protein D910_11928 [Dendroctonus ponderosae] 642911030 XM_008195294.1 438 0 PREDICTED: Tribolium castaneum probable RNA-binding protein orb2 (LOC657803), mRNA K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 Q9VSR3 1363 1.1e-148 Probable RNA-binding protein orb2 OS=Drosophila melanogaster GN=orb2 PE=1 SV=1 PF00076//PF16367//PF00643 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//B-box zinc finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular KOG0129 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.36065 BP_3 83.70 4.17 1260 642938917 XP_001808877.2 711 2.9e-72 PREDICTED: suppressor protein SRP40-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03884 Domain of unknown function (DUF329) -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36066 BP_3 2161.36 78.25 1623 270007710 EFA04158.1 1449 1.0e-157 hypothetical protein TcasGA2_TC014404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82198 212 1.1e-15 Transforming growth factor-beta-induced protein ig-h3 OS=Mus musculus GN=Tgfbi PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36067 BP_3 1251.94 24.60 2745 642925622 XP_008194644.1 2385 5.0e-266 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 1 [Tribolium castaneum]>gi|270008661|gb|EFA05109.1| hypothetical protein TcasGA2_TC015209 [Tribolium castaneum] 642925621 XM_008196422.1 311 1.62157e-159 PREDICTED: Tribolium castaneum polypeptide N-acetylgalactosaminyltransferase 1 (LOC662156), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV20 1326 1.3e-144 Polypeptide N-acetylgalactosaminyltransferase 1 OS=Drosophila melanogaster GN=GalNAc-T1 PE=2 SV=2 PF12300 Protein of unknown function (DUF3628) GO:0006486 protein glycosylation GO:0016757//GO:0016817 transferase activity, transferring glycosyl groups//hydrolase activity, acting on acid anhydrides GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.36068 BP_3 8062.00 905.20 721 478263038 ENN81438.1 629 5.4e-63 hypothetical protein YQE_02131, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q25490 155 2.0e-09 Apolipophorins OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36069 BP_3 455.56 3.06 7469 270011103 EFA07551.1 3565 0.0e+00 semaphorin-1a-like protein [Tribolium castaneum] 642930289 XM_008198109.1 776 0 PREDICTED: Tribolium castaneum semaphorin-1A (LOC660780), transcript variant X2, mRNA K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q24322 2582 8.0e-290 Semaphorin-1A OS=Drosophila melanogaster GN=Sema-1a PE=2 SV=2 PF01403//PF01437//PF05700 Sema domain//Plexin repeat//Breast carcinoma amplified sequence 2 (BCAS2) GO:0006397 mRNA processing GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.36071 BP_3 123.03 1.63 3931 546670831 ERL83427.1 3538 0.0e+00 hypothetical protein D910_00401 [Dendroctonus ponderosae] 242021484 XM_002431130.1 400 0 Pediculus humanus corporis protein transport protein Sec23A, putative, mRNA K14006 SEC23 protein transport protein SEC23 http://www.genome.jp/dbget-bin/www_bget?ko:K14006 A2VDL8 3038 0.0e+00 Protein transport protein Sec23A OS=Bos taurus GN=SEC23A PE=2 SV=1 PF04815//PF04811//PF04810 Sec23/Sec24 helical domain//Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1986 Vesicle coat complex COPII, subunit SEC23 Cluster-8309.36073 BP_3 2221.00 82.97 1582 642912900 XP_008201300.1 156 8.4e-08 PREDICTED: uncharacterized protein LOC660583 [Tribolium castaneum]>gi|270001890|gb|EEZ98337.1| hypothetical protein TcasGA2_TC000791 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36074 BP_3 775.98 19.43 2217 546678005 ERL88729.1 1301 2.0e-140 hypothetical protein D910_06111 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BNA9 1005 1.7e-107 CCR4-NOT transcription complex subunit 11 OS=Rattus norvegicus GN=Cnot11 PE=2 SV=1 PF00451//PF03823 Scorpion short toxin, BmKK2//Neurokinin B GO:0006810//GO:0007217//GO:0009405 transport//tachykinin receptor signaling pathway//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.36078 BP_3 1198.29 6.52 9151 332374194 AEE62238.1 2095 7.0e-232 unknown [Dendroctonus ponderosae]>gi|478254520|gb|ENN74766.1| hypothetical protein YQE_08654, partial [Dendroctonus ponderosae] 332374193 BT127276.1 565 0 Dendroctonus ponderosae clone DPO011_E07 unknown mRNA -- -- -- -- P61022 645 4.0e-65 Calcineurin B homologous protein 1 OS=Mus musculus GN=Chp1 PE=1 SV=2 PF01522//PF12763//PF13499//PF00963//PF10591//PF13833//PF13405//PF13202//PF00036 Polysaccharide deacetylase//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Cohesin domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand//EF hand GO:0007165//GO:0000272//GO:0005975//GO:0006807 signal transduction//polysaccharide catabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0005515//GO:0030246//GO:0005509//GO:0016810 protein binding//carbohydrate binding//calcium ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0005578 proteinaceous extracellular matrix KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.36079 BP_3 57.00 31.63 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36080 BP_3 322.18 9.26 1968 91089747 XP_975172.1 1664 1.4e-182 PREDICTED: bifunctional coenzyme A synthase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K02318 COASY phosphopantetheine adenylyltransferase / dephospho-CoA kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02318 Q8MIR4 807 1.4e-84 Bifunctional coenzyme A synthase OS=Sus scrofa GN=COASY PE=1 SV=1 PF01467//PF01121 Cytidylyltransferase-like//Dephospho-CoA kinase GO:0015937//GO:0009058//GO:0015940 coenzyme A biosynthetic process//biosynthetic process//pantothenate biosynthetic process GO:0004140//GO:0005524//GO:0003824 dephospho-CoA kinase activity//ATP binding//catalytic activity -- -- KOG3351 Predicted nucleotidyltransferase Cluster-8309.36083 BP_3 959.00 33.37 1677 91082895 XP_972070.1 995 4.6e-105 PREDICTED: la protein homolog [Tribolium castaneum]>gi|270007069|gb|EFA03517.1| hypothetical protein TcasGA2_TC013519 [Tribolium castaneum] -- -- -- -- -- K11090 LA, SSB lupus La protein http://www.genome.jp/dbget-bin/www_bget?ko:K11090 Q26457 577 5.5e-58 La protein homolog OS=Aedes albopictus PE=1 SV=1 PF00076//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003723//GO:0097159//GO:1901363//GO:0003676 RNA binding//organic cyclic compound binding//heterocyclic compound binding//nucleic acid binding -- -- KOG4213 RNA-binding protein La Cluster-8309.36085 BP_3 27.24 0.54 2730 91085817 XP_974784.1 2184 1.0e-242 PREDICTED: peroxisomal multifunctional enzyme type 2 isoform X1 [Tribolium castaneum]>gi|270011047|gb|EFA07495.1| hydroxysteroid (17-beta) dehydrogenase 4 [Tribolium castaneum] 755989420 XM_011313878.1 42 5.54371e-10 PREDICTED: Fopius arisanus peroxisomal multifunctional enzyme type 2 (LOC105272013), mRNA K12405 HSD17B4 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K12405 Q9VXJ0 1713 1.7e-189 Peroxisomal multifunctional enzyme type 2 OS=Drosophila melanogaster GN=Mfe2 PE=1 SV=1 PF00106//PF02737 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0008152//GO:0006633//GO:0018874//GO:0006574//GO:0006550//GO:0055114//GO:0006552//GO:0006554//GO:0006568//GO:0006631 metabolic process//fatty acid biosynthetic process//benzoate metabolic process//valine catabolic process//isoleucine catabolic process//oxidation-reduction process//leucine catabolic process//lysine catabolic process//tryptophan metabolic process//fatty acid metabolic process GO:0032934//GO:0016491//GO:0000166//GO:0003857 sterol binding//oxidoreductase activity//nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity -- -- KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes Cluster-8309.36088 BP_3 57.43 2.45 1421 332376705 AEE63492.1 543 1.0e-52 unknown [Dendroctonus ponderosae] 332376704 BT128535.1 250 6.74124e-126 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 450 2.5e-43 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF09416 Troponin//RNA helicase (UPF2 interacting domain) GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0005524//GO:0008270//GO:0004386//GO:0003677 ATP binding//zinc ion binding//helicase activity//DNA binding GO:0005861//GO:0005737 troponin complex//cytoplasm KOG3977 Troponin I Cluster-8309.36089 BP_3 5263.38 104.13 2728 91085263 XP_966331.1 2279 9.6e-254 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum]>gi|270009222|gb|EFA05670.1| hypothetical protein TcasGA2_TC014954 [Tribolium castaneum] 826494758 XM_012685372.1 98 4.1044e-41 PREDICTED: Monomorium pharaonis scavenger receptor class B member 1 (LOC105839216), mRNA -- -- -- -- O18824 708 5.8e-73 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155//GO:0007165 cell adhesion//signal transduction GO:0004872 receptor activity GO:0016020//GO:0005764//GO:0016021 membrane//lysosome//integral component of membrane -- -- Cluster-8309.36090 BP_3 2031.35 16.76 6133 642920676 XP_008192517.1 375 1.3e-32 PREDICTED: troponin I isoform X10 [Tribolium castaneum] 332376704 BT128535.1 119 1.96995e-52 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 290 3.9e-24 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF01529//PF00992 DHHC palmitoyltransferase//Troponin -- -- GO:0008270 zinc ion binding GO:0005861 troponin complex -- -- Cluster-8309.36091 BP_3 1086.77 6.50 8354 189237141 XP_973425.2 1853 7.4e-204 PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like isoform X2 [Tribolium castaneum] 817198469 XM_012419460.1 305 1.07731e-155 PREDICTED: Orussus abietinus 2-oxoglutarate dehydrogenase, mitochondrial (LOC105696754), transcript variant X4, mRNA K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q148N0 1550 4.1e-170 2-oxoglutarate dehydrogenase, mitochondrial OS=Bos taurus GN=OGDH PE=2 SV=1 PF06467//PF00676//PF03127 MYM-type Zinc finger with FCS sequence motif//Dehydrogenase E1 component//GAT domain GO:0006886//GO:0008152 intracellular protein transport//metabolic process GO:0016624//GO:0008270 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//zinc ion binding GO:0005622 intracellular KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.36092 BP_3 13.23 0.57 1409 91076454 XP_971838.1 304 5.1e-25 PREDICTED: ubiquitin-like protein FUBI [Tribolium castaneum]>gi|270002576|gb|EEZ99023.1| hypothetical protein TcasGA2_TC004892 [Tribolium castaneum] -- -- -- -- -- K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 Q9W6Y0 138 3.7e-07 40S ribosomal protein S30 OS=Oryzias latipes GN=fau PE=3 SV=2 PF04758//PF00240 Ribosomal protein S30//Ubiquitin family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.36094 BP_3 466.26 29.48 1054 189234794 XP_001807213.1 935 2.6e-98 PREDICTED: protein SMG5 [Tribolium castaneum] -- -- -- -- -- K11125 SMG5, EST1B protein SMG5 http://www.genome.jp/dbget-bin/www_bget?ko:K11125 Q9UPR3 227 1.3e-17 Protein SMG5 OS=Homo sapiens GN=SMG5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36095 BP_3 250.05 2.93 4412 291170320 ADD82416.1 712 7.9e-72 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170319 GU584933.1 402 0 Batocera horsfieldi minus-C odorant binding protein 3 mRNA, complete cds -- -- -- -- -- -- -- -- PF01384//PF01395 Phosphate transporter family//PBP/GOBP family GO:0006817 phosphate ion transport GO:0005315//GO:0005549 inorganic phosphate transmembrane transporter activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.36096 BP_3 17.42 0.39 2465 546678917 ERL89455.1 252 9.6e-19 hypothetical protein D910_06822 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 135 1.5e-06 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00130//PF00096//PF10590//PF00628//PF13465//PF16622//PF02892//PF04810 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//PHD-finger//Zinc-finger double domain//zinc-finger C2H2-type//BED zinc finger//Sec23/Sec24 zinc finger GO:0035556//GO:0055114//GO:0006886//GO:0006888 intracellular signal transduction//oxidation-reduction process//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0016638//GO:0008270//GO:0005515//GO:0003677 metal ion binding//oxidoreductase activity, acting on the CH-NH2 group of donors//zinc ion binding//protein binding//DNA binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.36097 BP_3 1094.63 23.96 2494 642937100 XP_008198691.1 1242 1.6e-133 PREDICTED: uncharacterized protein LOC659764 [Tribolium castaneum] -- -- -- -- -- K16315 GSG2 serine/threonine-protein kinase haspin http://www.genome.jp/dbget-bin/www_bget?ko:K16315 P83103 759 6.5e-79 Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster GN=Haspin PE=2 SV=1 PF07714//PF03121//PF00069 Protein tyrosine kinase//Herpesviridae UL52/UL70 DNA primase//Protein kinase domain GO:0006269//GO:0006260//GO:0006351//GO:0006468 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated//protein phosphorylation GO:0004672//GO:0003896//GO:0005524 protein kinase activity//DNA primase activity//ATP binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2464 Serine/threonine kinase (haspin family) Cluster-8309.36098 BP_3 1290.00 25.08 2771 237681135 NP_001153712.1 2027 1.6e-224 catalase-like [Tribolium castaneum] 391339336 XM_003743960.1 266 1.69608e-134 PREDICTED: Metaseiulus occidentalis catalase-like (LOC100908415), mRNA K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 1756 1.8e-194 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 PF00199 Catalase GO:0055114//GO:0006804//GO:0006979//GO:0015947//GO:0006568 oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress//methane metabolic process//tryptophan metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-8309.36099 BP_3 284.93 17.90 1059 91079488 XP_968513.1 561 6.1e-55 PREDICTED: probable peptidyl-tRNA hydrolase 2 [Tribolium castaneum]>gi|270003441|gb|EEZ99888.1| hypothetical protein TcasGA2_TC002672 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 O76387 304 1.6e-26 Probable peptidyl-tRNA hydrolase 2 OS=Caenorhabditis elegans GN=C24G6.8 PE=3 SV=1 PF01981 Peptidyl-tRNA hydrolase PTH2 -- -- GO:0004045 aminoacyl-tRNA hydrolase activity -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.36100 BP_3 31.00 2.30 942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36101 BP_3 800.06 12.18 3459 820865920 XP_012349428.1 695 5.8e-70 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105736982 [Apis florea] 32527555 AY210843.1 1463 0 Tenebrio sp. JMM-2003 5.8S ribosomal RNA gene, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM7 161 2.0e-09 Putative uncharacterized protein ART2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART2 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36102 BP_3 138.43 11.15 890 642913601 XP_008201081.1 352 8.8e-31 PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZA47 134 6.9e-07 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36103 BP_3 1360.42 10.28 6672 189237751 XP_001812575.1 2496 1.6e-278 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 676 7.3e-69 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF08070//PF00787//PF04769 DTHCT (NUC029) region//PX domain//Mating-type protein MAT alpha 1 HMG-box GO:0045895//GO:0006265//GO:0007531 positive regulation of mating-type specific transcription, DNA-templated//DNA topological change//mating type determination GO:0008301//GO:0003918//GO:0035091//GO:0005524//GO:0003677 DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity//phosphatidylinositol binding//ATP binding//DNA binding GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.36105 BP_3 226.60 10.33 1349 642928322 XP_008195533.1 577 1.1e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.0e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.36106 BP_3 472.21 6.32 3891 642919443 XP_974536.2 1971 7.1e-218 PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum]>gi|642919445|ref|XP_008191871.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum] 158299880 XM_319893.4 444 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1797 4.4e-199 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF00270//PF00004//PF00096//PF08168//PF04851//PF06221 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Zinc finger, C2H2 type//NUC205 domain//Type III restriction enzyme, res subunit//Putative zinc finger motif, C2HC5-type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0003676//GO:0005524//GO:0016787//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//ATP binding//hydrolase activity//DNA binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.36107 BP_3 10304.28 130.35 4102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36109 BP_3 8496.64 505.43 1102 755856661 XP_011296442.1 357 2.9e-31 PREDICTED: polyubiquitin-B isoform X3 [Musca domestica] 69608590 AM040016.1 261 3.98858e-132 Timarcha balearica mRNA for ubiquitin/ribosomal protein S27Ae fusion protein (ubq/S27Ae gene) K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 P0CG60 351 5.9e-32 Polyubiquitin-B OS=Pongo pygmaeus GN=UBB PE=3 SV=1 PF06305//PF14560//PF00240//PF01599 Protein of unknown function (DUF1049)//Ubiquitin-like domain//Ubiquitin family//Ribosomal protein S27a GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005887//GO:0005840 integral component of plasma membrane//ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.36110 BP_3 162.04 1.68 4933 817011235 AKF11871.1 1486 1.6e-161 putative juvenile hormone epoxide hydrolase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 1230 3.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.36111 BP_3 27.70 0.63 2424 385845164 AFI81409.1 798 4.6e-82 lipoate protein ligase [Phyllotreta striolata] -- -- -- -- -- K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 311 5.6e-27 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF03099//PF08127 Biotin/lipoate A/B protein ligase family//Peptidase family C1 propeptide GO:0006464//GO:0006508//GO:0050790 cellular protein modification process//proteolysis//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.36113 BP_3 5865.82 733.81 677 821003176 XP_012365190.1 1127 9.1e-121 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 665807220 XM_008553656.1 320 3.82418e-165 PREDICTED: Microplitis demolitor polyubiquitin-A (LOC103574248), mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 1127 3.7e-122 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF14560//PF00240//PF04452 Ubiquitin-like domain//Ubiquitin family//RNA methyltransferase GO:0006364 rRNA processing GO:0005515//GO:0008168 protein binding//methyltransferase activity -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.36114 BP_3 85.57 0.75 5778 91083731 XP_970731.1 1545 2.6e-168 PREDICTED: tyrosine aminotransferase [Tribolium castaneum]>gi|270006803|gb|EFA03251.1| hypothetical protein TcasGA2_TC013185 [Tribolium castaneum] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 Q8QZR1 1098 7.4e-118 Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1 SV=1 PF02854//PF04834//PF11095//PF01053//PF01212//PF00155 MIF4G domain//Early E3 14.5 kDa protein//Gem-associated protein 7 (Gemin7)//Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II GO:0009094//GO:0006103//GO:0000162//GO:0006520//GO:0009821//GO:0009072//GO:0006571//GO:0009058//GO:0009966//GO:0006536 L-phenylalanine biosynthetic process//2-oxoglutarate metabolic process//tryptophan biosynthetic process//cellular amino acid metabolic process//alkaloid biosynthetic process//aromatic amino acid family metabolic process//tyrosine biosynthetic process//biosynthetic process//regulation of signal transduction//glutamate metabolic process GO:0003723//GO:0004838//GO:0030170//GO:0005515//GO:0016829 RNA binding//L-tyrosine:2-oxoglutarate aminotransferase activity//pyridoxal phosphate binding//protein binding//lyase activity GO:0032797//GO:0016021 SMN complex//integral component of membrane KOG0259 Tyrosine aminotransferase Cluster-8309.36115 BP_3 225.46 2.28 5065 642937921 XP_008199131.1 1313 1.8e-141 PREDICTED: synapsin, partial [Tribolium castaneum] 645024540 XM_008215666.1 69 1.01314e-24 PREDICTED: Nasonia vitripennis synapsin (LOC100114347), mRNA -- -- -- -- Q6QM28 795 8.8e-83 Synapsin OS=Helix pomatia GN=SYN PE=1 SV=1 PF02786//PF13673//PF15096 Carbamoyl-phosphate synthase L chain, ATP binding domain//Acetyltransferase (GNAT) domain//G6B family GO:0042967 acyl-carrier-protein biosynthetic process GO:0005524//GO:0008080 ATP binding//N-acetyltransferase activity GO:0016021 integral component of membrane KOG3895 Synaptic vesicle protein Synapsin Cluster-8309.36116 BP_3 19.99 0.33 3249 270009835 EFA06283.1 505 5.8e-48 hypothetical protein TcasGA2_TC009149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DFB8 147 7.8e-08 Tetratricopeptide repeat protein 37 OS=Xenopus laevis GN=ttc37 PE=2 SV=1 PF13374//PF00515//PF13414//PF13176//PF06481//PF13181//PF13174//PF16045 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//COX Aromatic Rich Motif//Tetratricopeptide repeat//Tetratricopeptide repeat//LisH GO:0006118//GO:0022900//GO:0055114 obsolete electron transport//electron transport chain//oxidation-reduction process GO:0008827//GO:0005515 cytochrome o ubiquinol oxidase activity//protein binding GO:0016021//GO:0009319 integral component of membrane//cytochrome o ubiquinol oxidase complex -- -- Cluster-8309.36119 BP_3 6352.09 709.90 723 264667385 ACY71278.1 688 7.8e-70 ribosomal protein S11 [Chrysomela tremula] 565446497 XM_006284601.1 48 6.55411e-14 Capsella rubella hypothetical protein (CARUB_v10005922mg) mRNA, complete cds K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P41115 603 2.3e-61 40S ribosomal protein S11 OS=Xenopus laevis GN=rps11 PE=2 SV=1 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.36120 BP_3 47.47 1.70 1636 189234118 XP_001811130.1 634 3.2e-63 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] 153907106 AK262902.1 40 4.26309e-09 Gryllus bimaculatus mRNA, GBcontig09763 -- -- -- -- -- -- -- -- PF05757//PF09726 Oxygen evolving enhancer protein 3 (PsbQ)//Transmembrane protein GO:0015979 photosynthesis GO:0005509 calcium ion binding GO:0016021//GO:0019898//GO:0009654//GO:0009523 integral component of membrane//extrinsic component of membrane//photosystem II oxygen evolving complex//photosystem II -- -- Cluster-8309.36123 BP_3 27528.01 125.31 10880 642911258 XP_008199793.1 10422 0.0e+00 PREDICTED: filamin-A isoform X3 [Tribolium castaneum] 642911257 XM_008201571.1 1826 0 PREDICTED: Tribolium castaneum filamin-A (LOC661488), transcript variant X3, mRNA K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q9VEN1 7814 0.0e+00 Filamin-A OS=Drosophila melanogaster GN=cher PE=1 SV=2 PF00307//PF00688//PF01105 Calponin homology (CH) domain//TGF-beta propeptide//emp24/gp25L/p24 family/GOLD GO:0007165//GO:0040007//GO:0008283//GO:0006810 signal transduction//growth//cell proliferation//transport GO:0008083//GO:0005515 growth factor activity//protein binding GO:0016021 integral component of membrane KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.36127 BP_3 283.85 6.28 2471 189236205 XP_970721.2 2504 7.1e-280 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] 569534448 KF724681.1 127 2.81175e-57 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q8BJ56 699 5.8e-72 Patatin-like phospholipase domain-containing protein 2 OS=Mus musculus GN=Pnpla2 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.36128 BP_3 25.04 1.14 1351 270001100 EEZ97547.1 288 3.5e-23 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] -- -- -- -- -- K16175 SCRIB protein scribble http://www.genome.jp/dbget-bin/www_bget?ko:K16175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36130 BP_3 3484.21 64.44 2898 478257447 ENN77603.1 709 1.2e-71 hypothetical protein YQE_05898, partial [Dendroctonus ponderosae]>gi|546679842|gb|ERL90230.1| hypothetical protein D910_07583 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SQH8 260 5.5e-21 Uncharacterized protein C6orf136 OS=Homo sapiens GN=C6orf136 PE=2 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG4457 Uncharacterized conserved protein Cluster-8309.36131 BP_3 376.64 4.76 4109 91093345 XP_967700.1 926 1.1e-96 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X9 [Tribolium castaneum] 642938317 XM_962607.3 231 7.22431e-115 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 P81269 205 1.9e-14 Cyclic AMP-dependent transcription factor ATF-1 OS=Mus musculus GN=Atf1 PE=1 SV=1 PF12387//PF03131//PF07716//PF00170//PF02173 Pestivirus NS2 peptidase//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor//pKID domain GO:0006144//GO:0006508//GO:0006355 purine nucleobase metabolic process//proteolysis//regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0070008//GO:0003968//GO:0017111//GO:0016817//GO:0004197//GO:0043565//GO:0004252//GO:0003700 DNA binding//protein binding//serine-type exopeptidase activity//RNA-directed RNA polymerase activity//nucleoside-triphosphatase activity//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//sequence-specific DNA binding//serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0031379 nucleus//transcription factor complex//RNA-directed RNA polymerase complex -- -- Cluster-8309.36132 BP_3 547.00 36.60 1012 642925630 XP_008194648.1 994 3.6e-105 PREDICTED: proteasome subunit beta type-3 [Tribolium castaneum]>gi|270008657|gb|EFA05105.1| hypothetical protein TcasGA2_TC015205 [Tribolium castaneum] 642925629 XM_008196426.1 197 1.38035e-96 PREDICTED: Tribolium castaneum proteasome subunit beta type-3 (LOC662410), mRNA K02735 PSMB3 20S proteasome subunit beta 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02735 Q9XYN7 797 1.0e-83 Proteasome subunit beta type-3 OS=Drosophila melanogaster GN=Prosbeta3 PE=1 SV=1 PF00227//PF03348 Proteasome subunit//Serine incorporator (Serinc) GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005737//GO:0005634//GO:0005839//GO:0016020 cytoplasm//nucleus//proteasome core complex//membrane KOG0180 20S proteasome, regulatory subunit beta type PSMB3/PUP3 Cluster-8309.36133 BP_3 679.24 9.69 3672 282165741 NP_001164113.1 2452 1.1e-273 cap-n-collar [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 5.2e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF07716//PF00170//PF03131//PF03126 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor//Plus-3 domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3863 bZIP transcription factor NRF1 Cluster-8309.36134 BP_3 4334.49 23.51 9178 817065912 XP_012254772.1 7951 0.0e+00 PREDICTED: translational activator GCN1 [Athalia rosae] 820859669 XM_003697079.2 474 0 PREDICTED: Apis florea translational activator GCN1 (LOC100865997), mRNA -- -- -- -- Q92616 5791 0.0e+00 Translational activator GCN1 OS=Homo sapiens GN=GCN1L1 PE=1 SV=6 PF01602//PF04546//PF00042//PF08064//PF02269//PF02985//PF00125 Adaptin N terminal region//Sigma-70, non-essential region//Globin//UME (NUC010) domain//Transcription initiation factor IID, 18kD subunit//HEAT repeat//Core histone H2A/H2B/H3/H4 GO:0006366//GO:0016310//GO:0006352//GO:0009069//GO:0016192//GO:0006886//GO:0006355 transcription from RNA polymerase II promoter//phosphorylation//DNA-templated transcription, initiation//serine family amino acid metabolic process//vesicle-mediated transport//intracellular protein transport//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0020037//GO:0016987//GO:0019825//GO:0003700//GO:0004674 protein binding//DNA binding//heme binding//sigma factor activity//oxygen binding//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity GO:0005667//GO:0030117 transcription factor complex//membrane coat KOG1242 Protein containing adaptin N-terminal region Cluster-8309.36135 BP_3 122.89 1.17 5346 189239886 XP_969203.2 1791 7.3e-197 PREDICTED: protein tweety [Tribolium castaneum] 642931168 XM_964110.3 243 2.01008e-121 PREDICTED: Tribolium castaneum protein tweety (LOC657663), mRNA -- -- -- -- Q9U6L4 1074 4.1e-115 Protein tweety OS=Drosophila melanogaster GN=tty PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36136 BP_3 292.76 7.36 2208 194363749 NP_001123908.1 2107 6.9e-234 cytochrome P450 CYP18A1 [Tribolium castaneum]>gi|270014221|gb|EFA10669.1| cytochrome P450 18A1 [Tribolium castaneum] 658847169 XM_008407855.1 40 5.7862e-09 PREDICTED: Poecilia reticulata cytochrome P450 2J1-like (LOC103464052), mRNA K14985 CYP18A1 26-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K14985 Q95078 1439 8.1e-158 Cytochrome P450 18a1 OS=Drosophila melanogaster GN=Cyp18a1 PE=2 SV=2 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0005506//GO:0016712//GO:0020037 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen//heme binding -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.36137 BP_3 102.05 6.22 1082 91082539 XP_973726.1 648 5.1e-65 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 1.7e-23 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.36138 BP_3 460.52 5.00 4735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36139 BP_3 24.36 0.94 1537 91090290 XP_971485.1 917 4.6e-96 PREDICTED: bax inhibitor 1 [Tribolium castaneum]>gi|270013796|gb|EFA10244.1| hypothetical protein TcasGA2_TC012443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7R1 591 1.2e-59 Bax inhibitor 1 OS=Pongo abelii GN=TMBIM6 PE=2 SV=2 -- -- GO:0043066 negative regulation of apoptotic process -- -- GO:0016021 integral component of membrane KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1 Cluster-8309.36141 BP_3 9.00 0.38 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36142 BP_3 10700.00 468.31 1393 332375238 AEE62760.1 561 8.0e-55 unknown [Dendroctonus ponderosae]>gi|478259298|gb|ENN79200.1| hypothetical protein YQE_04384, partial [Dendroctonus ponderosae]>gi|546681740|gb|ERL91772.1| hypothetical protein D910_09098 [Dendroctonus ponderosae] 332375237 BT127798.1 174 1.16962e-83 Dendroctonus ponderosae clone DPO058_I06 unknown mRNA K01527 EGD1, BTF3 nascent polypeptide-associated complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01527 Q18885 420 7.4e-40 Transcription factor BTF3 homolog OS=Caenorhabditis elegans GN=icd-1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2240 RNA polymerase II general transcription factor BTF3 and related proteins Cluster-8309.36143 BP_3 559.25 5.19 5483 91094499 XP_971436.1 1375 1.3e-148 PREDICTED: phosphopantothenate--cysteine ligase [Tribolium castaneum]>gi|270000749|gb|EEZ97196.1| hypothetical protein TcasGA2_TC004384 [Tribolium castaneum] -- -- -- -- -- K01922 PPCS, coaB phosphopantothenate-cysteine ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01922 Q9HAB8 616 5.5e-62 Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2728 Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase Cluster-8309.36144 BP_3 644.45 7.81 4271 189240108 XP_972976.2 3649 0.0e+00 PREDICTED: trifunctional purine biosynthetic protein adenosine-3 [Tribolium castaneum]>gi|270011705|gb|EFA08153.1| hypothetical protein TcasGA2_TC005772 [Tribolium castaneum] 686609239 XM_009282957.1 67 1.10365e-23 PREDICTED: Aptenodytes forsteri trifunctional purine biosynthetic protein adenosine-3 (LOC103901972), mRNA K11787 GART phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase http://www.genome.jp/dbget-bin/www_bget?ko:K11787 P21872 2756 3.0e-310 Trifunctional purine biosynthetic protein adenosine-3 OS=Gallus gallus GN=GART PE=2 SV=1 PF02843//PF02844//PF02786//PF00551//PF02655 Phosphoribosylglycinamide synthetase, C domain//Phosphoribosylglycinamide synthetase, N domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//Formyl transferase//ATP-grasp domain GO:0006189//GO:0009113//GO:0006144//GO:0046653//GO:0009058//GO:0009256//GO:0032259 'de novo' IMP biosynthetic process//purine nucleobase biosynthetic process//purine nucleobase metabolic process//tetrahydrofolate metabolic process//biosynthetic process//10-formyltetrahydrofolate metabolic process//methylation GO:0005524//GO:0004641//GO:0016742//GO:0004637//GO:0008168//GO:0046872//GO:0004644 ATP binding//phosphoribosylformylglycinamidine cyclo-ligase activity//hydroxymethyl-, formyl- and related transferase activity//phosphoribosylamine-glycine ligase activity//methyltransferase activity//metal ion binding//phosphoribosylglycinamide formyltransferase activity GO:0005737 cytoplasm KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS) Cluster-8309.36145 BP_3 263.01 5.43 2627 642923827 XP_008193896.1 1863 1.6e-205 PREDICTED: endonuclease/exonuclease/phosphatase family domain-containing protein 1-like [Tribolium castaneum]>gi|270007767|gb|EFA04215.1| hypothetical protein TcasGA2_TC014464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEQ0 642 2.5e-65 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Danio rerio GN=eepd1 PE=2 SV=1 PF00633//PF06514//PF03934 Helix-hairpin-helix motif//Photosystem II 12 kDa extrinsic protein (PsbU)//Type II secretion system (T2SS), protein K GO:0042549//GO:0009306//GO:0006281//GO:0015979 photosystem II stabilization//protein secretion//DNA repair//photosynthesis GO:0003677 DNA binding GO:0009523//GO:0009654//GO:0019898//GO:0016021 photosystem II//photosystem II oxygen evolving complex//extrinsic component of membrane//integral component of membrane -- -- Cluster-8309.36146 BP_3 696.00 6.44 5498 332375580 AEE62931.1 1344 5.1e-145 unknown [Dendroctonus ponderosae]>gi|478259047|gb|ENN78990.1| hypothetical protein YQE_04541, partial [Dendroctonus ponderosae]>gi|546678360|gb|ERL88993.1| hypothetical protein D910_06371 [Dendroctonus ponderosae] 752869446 XM_011253537.1 134 8.09537e-61 PREDICTED: Camponotus floridanus cytochrome c oxidase assembly protein COX11, mitochondrial (LOC105248637), transcript variant X3, mRNA K15407 QTRTD1 queuine tRNA-ribosyltransferase subunit QTRTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15407 Q16RF5 720 4.8e-74 Queuine tRNA-ribosyltransferase subunit QTRTD1 homolog OS=Aedes aegypti GN=AAEL010968 PE=3 SV=1 PF01567//PF04442//PF01702 Hantavirus glycoprotein G1//Cytochrome c oxidase assembly protein CtaG/Cox11//Queuine tRNA-ribosyltransferase GO:0006400//GO:0030683//GO:0008616 tRNA modification//evasion or tolerance by virus of host immune response//queuosine biosynthetic process GO:0005507//GO:0008479 copper ion binding//queuine tRNA-ribosyltransferase activity GO:0019012 virion KOG2540 Cytochrome oxidase assembly factor COX11 Cluster-8309.36147 BP_3 64.70 1.83 1992 642931814 XP_008196744.1 1778 8.7e-196 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1209 3.4e-131 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.36148 BP_3 1462.00 63.13 1408 91092178 XP_968474.1 835 1.4e-86 PREDICTED: ras-related protein Rap-2c [Tribolium castaneum]>gi|270014441|gb|EFA10889.1| hypothetical protein TcasGA2_TC001713 [Tribolium castaneum] 60098716 AJ851555.1 78 2.74739e-30 Gallus gallus mRNA for hypothetical protein, clone 6p4 K07839 RAP2C Ras-related protein Rap-2C http://www.genome.jp/dbget-bin/www_bget?ko:K07839 Q9Y3L5 621 3.7e-63 Ras-related protein Rap-2c OS=Homo sapiens GN=RAP2C PE=1 SV=1 PF01637//PF01926//PF08477//PF03193//PF02421//PF00025//PF00071 Archaeal ATPase//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Ferrous iron transport protein B//ADP-ribosylation factor family//Ras family GO:0006184//GO:0015684//GO:0007264 obsolete GTP catabolic process//ferrous iron transport//small GTPase mediated signal transduction GO:0005524//GO:0015093//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//GTP binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0395 Ras-related GTPase Cluster-8309.36149 BP_3 80.83 1.99 2250 642916737 XP_008192408.1 1649 9.0e-181 PREDICTED: homeobox protein araucan isoform X3 [Tribolium castaneum] 642916736 XM_008194186.1 791 0 PREDICTED: Tribolium castaneum homeobox protein araucan (LOC652944), transcript variant X3, mRNA -- -- -- -- Q24248 725 5.1e-75 Homeobox protein araucan OS=Drosophila melanogaster GN=ara PE=1 SV=2 PF00046//PF04931//PF00335//PF05920 Homeobox domain//DNA polymerase phi//Tetraspanin family//Homeobox KN domain GO:0006355//GO:0006351//GO:0006260 regulation of transcription, DNA-templated//transcription, DNA-templated//DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0016021//GO:0042575 integral component of membrane//DNA polymerase complex KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.3615 BP_3 3.00 0.64 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36150 BP_3 249.08 2.32 5464 91095331 XP_975275.1 3723 0.0e+00 PREDICTED: von Willebrand factor A domain-containing protein 8 [Tribolium castaneum]>gi|270017220|gb|EFA13666.1| hypothetical protein TcasGA2_TC004261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CC88 2294 1.4e-256 von Willebrand factor A domain-containing protein 8 OS=Mus musculus GN=Vwa8 PE=2 SV=2 PF00421//PF00004//PF07728//PF08477//PF01695//PF01926//PF00158//PF00493//PF04670//PF00910//PF03193//PF07726//PF00005//PF00006//PF01637//PF07724//PF01443 Photosystem II protein//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//IstB-like ATP binding protein//50S ribosome-binding GTPase//Sigma-54 interaction domain//MCM2/3/5 family//Gtr1/RagA G protein conserved region//RNA helicase//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//AAA domain (Cdc48 subfamily)//Viral (Superfamily 1) RNA helicase GO:0007264//GO:0009767//GO:0019684//GO:0006355//GO:0006260 small GTPase mediated signal transduction//photosynthetic electron transport chain//photosynthesis, light reaction//regulation of transcription, DNA-templated//DNA replication GO:0003723//GO:0003677//GO:0017111//GO:0003724//GO:0005525//GO:0008134//GO:0003924//GO:0005524//GO:0016168//GO:0000166//GO:0016887 RNA binding//DNA binding//nucleoside-triphosphatase activity//RNA helicase activity//GTP binding//transcription factor binding//GTPase activity//ATP binding//chlorophyll binding//nucleotide binding//ATPase activity GO:0005667//GO:0016020//GO:0009521 transcription factor complex//membrane//photosystem KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.36151 BP_3 28.83 0.55 2822 189241005 XP_969371.2 1044 1.6e-110 PREDICTED: polymerase delta-interacting protein 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY77 178 1.7e-11 Polymerase delta-interacting protein 3 OS=Homo sapiens GN=POLDIP3 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.36152 BP_3 84.80 1.21 3683 3127936 CAA06690.1 1436 7.3e-156 nuclear receptor [Tenebrio molitor] -- -- -- -- -- K08543 NR2C1, TR2 testicular receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08543 Q6GN21 619 1.6e-62 Nuclear receptor subfamily 2 group C member 1-A OS=Xenopus laevis GN=nr2c1-a PE=2 SV=1 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36153 BP_3 130.90 5.82 1376 91089929 XP_973045.1 495 3.6e-47 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00436 Single-strand binding protein family -- -- GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.36154 BP_3 5834.90 125.37 2535 264667403 ACY71287.1 544 1.4e-52 ribosomal protein L35A [Chrysomela tremula] 389610812 AK402395.1 47 8.55057e-13 Papilio polytes mRNA for ribosomal protein L35A, complete cds, sequence id: Pp-0167 K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 P18077 367 1.9e-33 60S ribosomal protein L35a OS=Homo sapiens GN=RPL35A PE=1 SV=2 PF01782//PF01247 RimM N-terminal domain//Ribosomal protein L35Ae GO:0006364//GO:0042254//GO:0006412 rRNA processing//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-8309.36155 BP_3 10683.98 365.41 1701 91088233 XP_973769.1 723 1.6e-73 PREDICTED: elongation factor 1-beta' [Tribolium castaneum]>gi|270011822|gb|EFA08270.1| hypothetical protein TcasGA2_TC005900 [Tribolium castaneum] -- -- -- -- -- K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 P29522 600 1.2e-60 Elongation factor 1-beta' OS=Bombyx mori PE=1 SV=2 PF00736//PF05209 EF-1 guanine nucleotide exchange domain//Septum formation inhibitor MinC, N-terminal domain GO:0006414//GO:0051302//GO:0006448//GO:0006412 translational elongation//regulation of cell division//regulation of translational elongation//translation GO:0003746 translation elongation factor activity GO:0005853//GO:0005840 eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.36156 BP_3 157.03 5.90 1575 332375240 AEE62761.1 1172 1.3e-125 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O35075 845 4.4e-89 Down syndrome critical region protein 3 homolog OS=Mus musculus GN=Dscr3 PE=2 SV=1 PF08923 Mitogen-activated protein kinase kinase 1 interacting GO:0032006 regulation of TOR signaling -- -- -- -- KOG2717 Uncharacterized conserved protein with similarity to embryogenesis protein H beta 58 and VPS26 Cluster-8309.36157 BP_3 110609.34 2540.80 2390 752822710 AJG42379.1 1960 8.2e-217 actin [Leptinotarsa decemlineata] 55783599 AY817141.1 1311 0 Apriona germari actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P41339 1908 3.6e-212 Actin, acrosomal process isoform OS=Limulus polyphemus PE=2 SV=1 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- KOG0676 Actin and related proteins Cluster-8309.36158 BP_3 563.68 64.65 712 478263483 ENN81838.1 154 6.4e-08 hypothetical protein YQE_01777, partial [Dendroctonus ponderosae]>gi|546685487|gb|ERL94985.1| hypothetical protein D910_12257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36160 BP_3 675.15 13.79 2652 270005721 EFA02169.1 729 5.1e-74 hypothetical protein TcasGA2_TC007825 [Tribolium castaneum] -- -- -- -- -- K16751 C2CD3 C2 domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16751 Q4AC94 264 1.7e-21 C2 domain-containing protein 3 OS=Homo sapiens GN=C2CD3 PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36161 BP_3 4257.01 88.05 2622 755959123 XP_011304293.1 2156 1.7e-239 PREDICTED: eukaryotic peptide chain release factor subunit 1 isoform X1 [Fopius arisanus] 642912506 XM_966575.3 612 0 PREDICTED: Tribolium castaneum eukaryotic peptide chain release factor subunit 1 (LOC660337), mRNA K03265 ETF1, ERF1 peptide chain release factor subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03265 Q9VPH7 2131 5.5e-238 Eukaryotic peptide chain release factor subunit 1 OS=Drosophila melanogaster GN=eRF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0688 Peptide chain release factor 1 (eRF1) Cluster-8309.36162 BP_3 460.99 3.74 6231 642911068 XP_008200561.1 1616 1.7e-176 PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum]>gi|642911070|ref|XP_008200562.1| PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum] 642911069 XM_008202340.1 536 0 PREDICTED: Tribolium castaneum ELAV-like protein 4 (LOC659897), transcript variant X2, mRNA K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 Q7SZT7 1034 2.1e-110 ELAV-like protein 4 OS=Xenopus laevis GN=elavl4 PE=2 SV=1 PF16367//PF00076//PF08675 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0046872//GO:0003676//GO:0004535 RNA binding//metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.36164 BP_3 203.97 13.65 1012 270003477 EEZ99924.1 1199 6.1e-129 hypothetical protein TcasGA2_TC002717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 947 4.2e-101 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF13417//PF07651 Glutathione S-transferase, N-terminal domain//ANTH domain -- -- GO:0005515//GO:0005543 protein binding//phospholipid binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.36166 BP_3 253.25 3.06 4285 642912316 XP_969236.2 1319 3.1e-142 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IF69 769 7.7e-80 NHL repeat-containing protein 2 OS=Bos taurus GN=NHLRC2 PE=2 SV=1 PF01731//PF01436//PF00085//PF00578 Arylesterase//NHL repeat//Thioredoxin//AhpC/TSA family GO:0055114//GO:0045454 oxidation-reduction process//cell redox homeostasis GO:0016209//GO:0016491//GO:0005515//GO:0004064 antioxidant activity//oxidoreductase activity//protein binding//arylesterase activity -- -- -- -- Cluster-8309.36167 BP_3 31.35 0.32 4985 642913546 XP_008201056.1 1646 4.4e-180 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 645 2.2e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF06007//PF07690//PF00083 Phosphonate metabolism protein PhnJ//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0019700//GO:0042916 transmembrane transport//organic phosphonate catabolic process//alkylphosphonate transport GO:0022857//GO:0016829 transmembrane transporter activity//lyase activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.36170 BP_3 132.33 2.64 2708 91079832 XP_970236.1 695 4.5e-70 PREDICTED: protein enabled isoform X1 [Tribolium castaneum]>gi|270003288|gb|EEZ99735.1| hypothetical protein TcasGA2_TC002504 [Tribolium castaneum] 642918238 XM_008193203.1 137 8.51198e-63 PREDICTED: Tribolium castaneum protein enabled (LOC658784), transcript variant X2, mRNA K05746 ENAH, MENA enabled http://www.genome.jp/dbget-bin/www_bget?ko:K05746 Q8T4F7 462 1.9e-44 Protein enabled OS=Drosophila melanogaster GN=ena PE=1 SV=4 PF04939//PF04800//PF00638 Ribosome biogenesis regulatory protein (RRS1)//ETC complex I subunit conserved region//RanBP1 domain GO:0022900//GO:0046907//GO:0042254 electron transport chain//intracellular transport//ribosome biogenesis GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0005634 nucleus KOG4590 Signal transduction protein Enabled, contains WH1 domain Cluster-8309.36171 BP_3 1805.72 15.02 6087 91084173 XP_966383.1 1434 2.1e-155 PREDICTED: serine/threonine-protein kinase pelle [Tribolium castaneum]>gi|270009272|gb|EFA05720.1| pelle [Tribolium castaneum] -- -- -- -- -- K04733 IRAK4 interleukin-1 receptor-associated kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04733 Q05652 685 6.0e-70 Serine/threonine-protein kinase pelle OS=Drosophila melanogaster GN=pll PE=1 SV=1 PF00069//PF00531//PF07714 Protein kinase domain//Death domain//Protein tyrosine kinase GO:0007165//GO:0009987//GO:0006468 signal transduction//cellular process//protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG1187 Serine/threonine protein kinase Cluster-8309.36172 BP_3 405.76 14.09 1680 546685827 ERL95270.1 1821 7.6e-201 hypothetical protein D910_12536 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NRA2 656 3.8e-67 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36174 BP_3 19.99 0.42 2590 642910330 XP_970349.3 1091 5.2e-116 PREDICTED: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGE0 671 1.1e-68 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Xenopus tropicalis GN=ogfod3 PE=2 SV=1 PF13640 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.36175 BP_3 406.31 2.33 8686 642911061 XP_008200558.1 3420 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2804 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00520//PF00813 Ion transport protein//FliP family GO:0055085//GO:0009306//GO:0006811 transmembrane transport//protein secretion//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.36176 BP_3 728.00 11.71 3288 91085657 XP_971289.1 2534 3.1e-283 PREDICTED: uncharacterized protein LOC659930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P27393 181 9.0e-12 Collagen alpha-2(IV) chain OS=Ascaris suum PE=2 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.36177 BP_3 109.28 2.27 2608 91076692 XP_971784.1 851 3.5e-88 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 [Tribolium castaneum]>gi|270001889|gb|EEZ98336.1| hypothetical protein TcasGA2_TC000790 [Tribolium castaneum] -- -- -- -- -- K10768 ALKBH6 alkylated DNA repair protein alkB homolog 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10768 Q6IQE9 559 1.1e-55 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Danio rerio GN=alkbh6 PE=2 SV=1 PF05615//PF07361//PF03171 Tho complex subunit 7//Cytochrome b562//2OG-Fe(II) oxygenase superfamily GO:0006118//GO:0022900//GO:0055114//GO:0006397 obsolete electron transport//electron transport chain//oxidation-reduction process//mRNA processing GO:0016706//GO:0009055//GO:0020037//GO:0005506//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//electron carrier activity//heme binding//iron ion binding//oxidoreductase activity GO:0000445//GO:0042597 THO complex part of transcription export complex//periplasmic space KOG3200 Uncharacterized conserved protein Cluster-8309.36178 BP_3 28.00 1.36 1284 642940077 XP_008192917.1 1068 1.2e-113 PREDICTED: UPF0489 protein C5orf22 homolog isoform X1 [Tribolium castaneum]>gi|270016013|gb|EFA12461.1| hypothetical protein TcasGA2_TC010608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PAE6 584 6.5e-59 UPF0489 protein C5orf22 homolog OS=Xenopus laevis PE=2 SV=1 PF01668 SmpB protein -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.36179 BP_3 8220.60 175.53 2549 642913818 XP_008201172.1 643 4.6e-64 PREDICTED: myosin light chain alkali isoform X1 [Tribolium castaneum] 642913817 XM_008202950.1 253 2.62816e-127 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 455 1.2e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF00036//PF13405//PF13499 EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.36180 BP_3 315.00 8.15 2154 91082503 XP_976395.1 305 6.0e-25 PREDICTED: uncharacterized protein LOC661760 [Tribolium castaneum]>gi|270007133|gb|EFA03581.1| hypothetical protein TcasGA2_TC013664 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36182 BP_3 819.00 27.45 1730 91084289 XP_967046.1 908 5.8e-95 PREDICTED: ras-related protein Rab-35 [Tribolium castaneum]>gi|270008813|gb|EFA05261.1| hypothetical protein TcasGA2_TC015416 [Tribolium castaneum] 765118842 XM_004068360.2 35 2.71636e-06 PREDICTED: Oryzias latipes ras-related protein Rab-8A (LOC101161304), mRNA K07876 RAB35, RAB1C Ras-related protein Rab-35 http://www.genome.jp/dbget-bin/www_bget?ko:K07876 Q6PHN9 769 3.1e-80 Ras-related protein Rab-35 OS=Mus musculus GN=Rab35 PE=1 SV=1 PF02421//PF00025//PF07728//PF08477//PF01926//PF10662//PF00071//PF04670//PF03193//PF00005//PF01637 Ferrous iron transport protein B//ADP-ribosylation factor family//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region//Protein of unknown function, DUF258//ABC transporter//Archaeal ATPase GO:0006576//GO:0015684//GO:0015031//GO:0007264 cellular biogenic amine metabolic process//ferrous iron transport//protein transport//small GTPase mediated signal transduction GO:0015093//GO:0005524//GO:0003924//GO:0016887//GO:0005525 ferrous iron transmembrane transporter activity//ATP binding//GTPase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.36183 BP_3 1062.60 13.75 4016 189238116 XP_001814107.1 722 5.0e-73 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00064//PF17050 Neuraminidase//Altered inheritance of mitochondria 5 GO:0042407//GO:0006687//GO:0005975 cristae formation//glycosphingolipid metabolic process//carbohydrate metabolic process GO:0004308 exo-alpha-sialidase activity GO:0016020//GO:0033644//GO:0061617//GO:0055036//GO:0044284 membrane//host cell membrane//MICOS complex//virion membrane//mitochondrial crista junction -- -- Cluster-8309.36185 BP_3 563.48 10.00 3008 282848149 NP_001164293.1 1147 1.9e-122 kayak isoform B [Tribolium castaneum] -- -- -- -- -- K09031 FOSLN fos-like antigen, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09031 B4K617 198 8.8e-14 Transcription factor kayak OS=Drosophila mojavensis GN=kay PE=3 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36186 BP_3 55.44 0.74 3911 642929255 XP_008195756.1 1279 1.2e-137 PREDICTED: PX domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270009666|gb|EFA06114.1| hypothetical protein TcasGA2_TC008957 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q8BX57 761 6.0e-79 PX domain-containing protein kinase-like protein OS=Mus musculus GN=Pxk PE=1 SV=2 PF00787//PF02205//PF02285 PX domain//WH2 motif//Cytochrome oxidase c subunit VIII GO:0006123//GO:0006468//GO:0007154//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//protein phosphorylation//cell communication//proton transport GO:0005524//GO:0035091//GO:0003779//GO:0004672//GO:0004129 ATP binding//phosphatidylinositol binding//actin binding//protein kinase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.36187 BP_3 13.92 0.54 1527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36189 BP_3 3889.00 846.58 513 264667451 ACY71311.1 406 2.8e-37 ribosomal protein L37A [Chrysomela tremula] 264667450 GU120461.1 174 4.12682e-84 Chrysomela tremulae ribosomal protein L37A (RpL37A) mRNA, complete cds K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 Q9VMU4 374 5.8e-35 60S ribosomal protein L37a OS=Drosophila melanogaster GN=RpL37A PE=1 SV=3 PF01780 Ribosomal L37ae protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0402 60S ribosomal protein L37 Cluster-8309.3619 BP_3 4.00 0.55 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36190 BP_3 60.53 1.01 3170 820865920 XP_012349428.1 676 8.5e-68 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105736982 [Apis florea] 37223294 AY310671.1 1367 0 Diaperinae sp. JAR-2003 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM7 174 5.6e-11 Putative uncharacterized protein ART2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART2 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36193 BP_3 12476.00 803.64 1040 21218346 AAM44043.1 779 3.2e-80 ferritin 1 [Apriona germari] 21218345 AF509878.1 275 6.19851e-140 Apriona germari ferritin 1 mRNA, complete cds K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 P41822 350 7.2e-32 Ferritin subunit OS=Aedes aegypti GN=FERH PE=1 SV=2 PF00210//PF02915 Ferritin-like domain//Rubrerythrin GO:0055114//GO:0006879 oxidation-reduction process//cellular iron ion homeostasis GO:0046872//GO:0016491//GO:0008199 metal ion binding//oxidoreductase activity//ferric iron binding -- -- -- -- Cluster-8309.36194 BP_3 656.41 3.52 9279 270015028 EFA11476.1 1443 2.9e-156 hypothetical protein TcasGA2_TC014187 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q70PU1 454 5.6e-43 Peptidoglycan-recognition protein SC2 OS=Drosophila simulans GN=PGRP-SC2 PE=3 SV=1 PF00620//PF01510//PF01365//PF03740//PF04840 RhoGAP domain//N-acetylmuramoyl-L-alanine amidase//RIH domain//Pyridoxal phosphate biosynthesis protein PdxJ//Vps16, C-terminal region GO:0070588//GO:0009253//GO:0006886//GO:0007165//GO:0006816//GO:0006807//GO:0009252//GO:0008615 calcium ion transmembrane transport//peptidoglycan catabolic process//intracellular protein transport//signal transduction//calcium ion transport//nitrogen compound metabolic process//peptidoglycan biosynthetic process//pyridoxine biosynthetic process GO:0005262//GO:0033856//GO:0008745 calcium channel activity//pyridoxine 5'-phosphate synthase activity//N-acetylmuramoyl-L-alanine amidase activity GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-8309.36195 BP_3 2274.82 37.24 3236 642913109 XP_008201396.1 2378 3.8e-265 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 186 5.88023e-90 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 1430 1.3e-156 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.36197 BP_3 1079.29 12.44 4474 642920299 XP_008192288.1 1517 3.6e-165 PREDICTED: interferon regulatory factor 2-binding protein 2 isoform X2 [Tribolium castaneum] 642920300 XM_008194067.1 94 1.13227e-38 PREDICTED: Tribolium castaneum interferon regulatory factor 2-binding protein 2 (LOC664517), transcript variant X3, mRNA -- -- -- -- E9Q1P8 403 2.2e-37 Interferon regulatory factor 2-binding protein 2 OS=Mus musculus GN=Irf2bp2 PE=1 SV=1 PF00097//PF02778 Zinc finger, C3HC4 type (RING finger)//tRNA intron endonuclease, N-terminal domain GO:0006388//GO:0051252 tRNA splicing, via endonucleolytic cleavage and ligation//regulation of RNA metabolic process GO:0000213//GO:0046872 tRNA-intron endonuclease activity//metal ion binding GO:0000214 tRNA-intron endonuclease complex KOG3579 Predicted E3 ubiquitin ligase Cluster-8309.36198 BP_3 732.67 8.86 4279 665814511 XP_008555868.1 4780 0.0e+00 PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor]>gi|665814513|ref|XP_008555869.1| PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor] 749751938 XM_011139992.1 608 0 PREDICTED: Harpegnathos saltator regulator of nonsense transcripts 1 (LOC105182511), transcript variant X4, mRNA K14326 UPF1, RENT1 regulator of nonsense transcripts 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14326 Q9EPU0 3940 0.0e+00 Regulator of nonsense transcripts 1 OS=Mus musculus GN=Upf1 PE=1 SV=2 PF00270//PF00580//PF04851//PF00004//PF00437//PF09416//PF00448//PF07728 DEAD/DEAH box helicase//UvrD/REP helicase N-terminal domain//Type III restriction enzyme, res subunit//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//RNA helicase (UPF2 interacting domain)//SRP54-type protein, GTPase domain//AAA domain (dynein-related subfamily) GO:0000184//GO:0006810//GO:0006614 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//transport//SRP-dependent cotranslational protein targeting to membrane GO:0003677//GO:0016787//GO:0004386//GO:0005524//GO:0016887//GO:0003676//GO:0008270//GO:0005525 DNA binding//hydrolase activity//helicase activity//ATP binding//ATPase activity//nucleic acid binding//zinc ion binding//GTP binding GO:0005737 cytoplasm KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.362 BP_3 620.00 48.89 903 91090834 XP_972042.1 476 3.7e-45 PREDICTED: uncharacterized protein LOC660742 [Tribolium castaneum]>gi|270013988|gb|EFA10436.1| hypothetical protein TcasGA2_TC012679 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36200 BP_3 7789.75 255.72 1760 642927566 XP_972340.2 667 5.2e-67 PREDICTED: 40S ribosomal protein S12 [Tribolium castaneum] -- -- -- -- -- K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P80455 492 4.2e-48 40S ribosomal protein S12 OS=Drosophila melanogaster GN=RpS12 PE=1 SV=2 PF02065 Melibiase GO:0006012//GO:0001575//GO:0046486//GO:0005975 galactose metabolic process//globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0004557 alpha-galactosidase activity -- -- KOG3406 40S ribosomal protein S12 Cluster-8309.36201 BP_3 916.00 33.72 1601 478258005 ENN78143.1 1332 3.7e-144 hypothetical protein YQE_05297, partial [Dendroctonus ponderosae] 543739188 XM_005510443.1 149 1.06502e-69 PREDICTED: Columba livia adenosine monophosphate deaminase 2 (AMPD2), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 1077 5.6e-116 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00962 Adenosine/AMP deaminase -- -- GO:0019239 deaminase activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.36202 BP_3 329.39 3.51 4812 147902182 NP_001079763.1 447 4.6e-41 ER lumen protein-retaining receptor 3 [Xenopus laevis]>gi|6685399|sp|O42580.1|ERD23_XENLA RecName: Full=ER lumen protein-retaining receptor 3; AltName: Full=KDEL endoplasmic reticulum protein retention receptor 3; Short=KDEL receptor 3 [Xenopus laevis]>gi|2467290|emb|CAA04817.1| KDEL receptor [Xenopus laevis]>gi|32450093|gb|AAH54181.1| MGC64313 protein [Xenopus laevis] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 Q66JF2 456 1.7e-43 ER lumen protein-retaining receptor 3 OS=Xenopus tropicalis GN=kdelr3 PE=2 SV=1 PF00810//PF05297 ER lumen protein retaining receptor//Herpesvirus latent membrane protein 1 (LMP1) GO:0006621//GO:0019087 protein retention in ER lumen//transformation of host cell by virus GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG3106 ER lumen protein retaining receptor Cluster-8309.36204 BP_3 167.88 3.24 2792 189240077 XP_971167.2 1708 1.6e-187 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 190 6.9e-13 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF13414//PF00856 TPR repeat//SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.36205 BP_3 2087.00 40.95 2748 546683090 ERL92945.1 1119 3.1e-119 hypothetical protein D910_10250, partial [Dendroctonus ponderosae] -- -- -- -- -- K09522 DNAJC2 DnaJ homolog subfamily C member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09522 Q1RMH9 666 4.4e-68 DnaJ homolog subfamily C member 2 OS=Bos taurus GN=DNAJC2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0724 Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains Cluster-8309.36208 BP_3 4569.40 81.23 3003 642936134 XP_008198313.1 3418 0.0e+00 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 722 0 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q8T674 926 3.4e-98 ABC transporter G family member 20 OS=Dictyostelium discoideum GN=abcG20 PE=3 SV=1 PF00005//PF03193//PF01061//PF13304 ABC transporter//Protein of unknown function, DUF258//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0003924//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ATP binding//GTP binding//ATPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.36209 BP_3 3233.65 410.92 671 478259615 ENN79468.1 186 1.2e-11 hypothetical protein YQE_04112, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36210 BP_3 22486.80 139.95 8036 642913015 XP_008201353.1 11416 0.0e+00 PREDICTED: spectrin alpha chain [Tribolium castaneum]>gi|270002786|gb|EEZ99233.1| alpha spectrin [Tribolium castaneum] 158296318 XM_316724.4 2095 0 Anopheles gambiae str. PEST AGAP006686-PA (AgaP_AGAP006686) mRNA, complete cds K06114 SPTA spectrin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06114 P13395 10164 0.0e+00 Spectrin alpha chain OS=Drosophila melanogaster GN=alpha-Spec PE=1 SV=2 PF00435//PF13499//PF13405//PF13833//PF13202//PF14604//PF00018//PF00036 Spectrin repeat//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Variant SH3 domain//SH3 domain//EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36211 BP_3 714.88 19.75 2036 91087493 XP_968456.1 1243 9.7e-134 PREDICTED: proteasome subunit alpha type-4 [Tribolium castaneum]>gi|270009464|gb|EFA05912.1| hypothetical protein TcasGA2_TC008727 [Tribolium castaneum] 766941897 XM_011505296.1 228 1.6518e-113 PREDICTED: Ceratosolen solmsi marchali proteasome subunit alpha type-4 (LOC105366753), transcript variant X3, mRNA K02728 PSMA4 20S proteasome subunit alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02728 P21670 1079 4.2e-116 Proteasome subunit alpha type-4 OS=Rattus norvegicus GN=Psma4 PE=1 SV=1 PF10584//PF08465//PF00227 Proteasome subunit A N-terminal signature//Thymidine kinase from Herpesvirus C-terminal//Proteasome subunit GO:0051603//GO:0006206//GO:0006511//GO:0006230 proteolysis involved in cellular protein catabolic process//pyrimidine nucleobase metabolic process//ubiquitin-dependent protein catabolic process//TMP biosynthetic process GO:0004298//GO:0004175//GO:0004797//GO:0005524 threonine-type endopeptidase activity//endopeptidase activity//thymidine kinase activity//ATP binding GO:0019773//GO:0005737//GO:0005839//GO:0005634 proteasome core complex, alpha-subunit complex//cytoplasm//proteasome core complex//nucleus KOG0178 20S proteasome, regulatory subunit alpha type PSMA4/PRE9 Cluster-8309.36212 BP_3 1134.85 31.78 2013 478252723 ENN73118.1 1681 1.6e-184 hypothetical protein YQE_10259, partial [Dendroctonus ponderosae] 157136796 XM_001656862.1 215 2.75167e-106 Aedes aegypti AAEL003514-RA mRNA K11131 DKC1, NOLA4, CBF5 H/ACA ribonucleoprotein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11131 O44081 1625 2.0e-179 H/ACA ribonucleoprotein complex subunit 4 OS=Drosophila melanogaster GN=Nop60B PE=1 SV=1 PF01509//PF01472 TruB family pseudouridylate synthase (N terminal domain)//PUA domain GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG2529 Pseudouridine synthase Cluster-8309.36213 BP_3 1772.00 53.27 1895 291170322 ADD82417.1 210 5.5e-14 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27017 155 5.4e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.36215 BP_3 21.00 2.62 678 642912272 XP_008200632.1 235 2.5e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01833 IPT/TIG domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36216 BP_3 144.22 3.24 2434 134131322 BAF49604.1 1050 2.8e-111 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 531 1.7e-52 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF00089 Glycosyl hydrolases family 18//Trypsin GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004252 hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type endopeptidase activity -- -- KOG2806 Chitinase Cluster-8309.36217 BP_3 2344.97 75.94 1780 332372941 AEE61612.1 1837 1.1e-202 unknown [Dendroctonus ponderosae] 642917730 XM_008193127.1 333 6.15639e-172 PREDICTED: Tribolium castaneum glutamine synthetase 2 cytoplasmic (LOC656087), transcript variant X4, mRNA K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 P20478 1509 5.0e-166 Glutamine synthetase 2 cytoplasmic OS=Drosophila melanogaster GN=Gs2 PE=2 SV=3 PF00120//PF01844//PF03951 Glutamine synthetase, catalytic domain//HNH endonuclease//Glutamine synthetase, beta-Grasp domain GO:0006807//GO:0009252//GO:0006542 nitrogen compound metabolic process//peptidoglycan biosynthetic process//glutamine biosynthetic process GO:0004356//GO:0004519//GO:0003676 glutamate-ammonia ligase activity//endonuclease activity//nucleic acid binding -- -- KOG0683 Glutamine synthetase Cluster-8309.36219 BP_3 706.07 12.95 2920 642929416 XP_008195830.1 1110 3.7e-118 PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929418|ref|XP_008195831.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929420|ref|XP_008195832.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q811S7 662 1.3e-67 Upstream-binding protein 1 OS=Mus musculus GN=Ubp1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.36221 BP_3 1115.15 23.32 2597 642911404 XP_008199408.1 893 4.8e-93 PREDICTED: uncharacterized protein LOC100142456 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GM59 233 6.7e-18 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.36222 BP_3 43.00 0.60 3727 642910934 XP_008193472.1 1263 8.5e-136 PREDICTED: probable serine/threonine-protein kinase kinX [Tribolium castaneum]>gi|270014958|gb|EFA11406.1| hypothetical protein TcasGA2_TC013580 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.36223 BP_3 46.58 0.87 2874 478254615 ENN74858.1 1746 6.5e-192 hypothetical protein YQE_08628, partial [Dendroctonus ponderosae] -- -- -- -- -- K03107 SRP68 signal recognition particle subunit SRP68 http://www.genome.jp/dbget-bin/www_bget?ko:K03107 Q9VSS2 1113 6.7e-120 Signal recognition particle subunit SRP68 OS=Drosophila melanogaster GN=Srp68 PE=2 SV=1 PF13176//PF16969//PF13414 Tetratricopeptide repeat//RNA-binding signal recognition particle 68//TPR repeat GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0030942//GO:0005047//GO:0005515 7S RNA binding//endoplasmic reticulum signal peptide binding//signal recognition particle binding//protein binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG2460 Signal recognition particle, subunit Srp68 Cluster-8309.36224 BP_3 9465.80 337.39 1644 91076986 XP_975465.1 1098 5.1e-117 PREDICTED: SPARC [Tribolium castaneum]>gi|270001994|gb|EEZ98441.1| hypothetical protein TcasGA2_TC000930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34714 555 1.9e-55 SPARC OS=Caenorhabditis elegans GN=ost-1 PE=1 SV=1 PF00713//PF09289//PF07648//PF10591 Hirudin//Follistatin/Osteonectin-like EGF domain//Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region GO:0007165 signal transduction GO:0005509//GO:0005515//GO:0004867 calcium ion binding//protein binding//serine-type endopeptidase inhibitor activity GO:0005578//GO:0005615 proteinaceous extracellular matrix//extracellular space KOG4004 Matricellular protein Osteonectin/SPARC/BM-40 Cluster-8309.36227 BP_3 1973.17 46.45 2339 642935904 XP_008198222.1 2533 2.9e-283 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X2 [Tribolium castaneum]>gi|270013982|gb|EFA10430.1| hypothetical protein TcasGA2_TC012671 [Tribolium castaneum] 170066649 XM_001868153.1 669 0 Culex quinquefasciatus calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2374 3.3e-266 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 -- -- GO:0006816//GO:0006754 calcium ion transport//ATP biosynthetic process GO:0005388//GO:0005524//GO:0046872 calcium-transporting ATPase activity//ATP binding//metal ion binding GO:0016021//GO:0016529 integral component of membrane//sarcoplasmic reticulum KOG0202 Ca2+ transporting ATPase Cluster-8309.36228 BP_3 9025.30 171.99 2821 332374576 AEE62429.1 1472 3.8e-160 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 295 1.30708e-150 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1258 1.0e-136 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191//PF00152 Annexin//tRNA synthetases class II (D, K and N) GO:0006418 tRNA aminoacylation for protein translation GO:0005509//GO:0005524//GO:0000166//GO:0005544//GO:0004812 calcium ion binding//ATP binding//nucleotide binding//calcium-dependent phospholipid binding//aminoacyl-tRNA ligase activity -- -- -- -- Cluster-8309.36229 BP_3 9524.43 1281.25 650 264667337 ACY71254.1 881 2.9e-92 ribosomal protein L11 [Chrysomela tremula] 242380639 FP096472.1 206 8.63295e-102 Phyllostachys edulis cDNA clone: bphylf002j10, full insert sequence K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 P46222 822 8.4e-87 60S ribosomal protein L11 OS=Drosophila melanogaster GN=RpL11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-8309.3623 BP_3 1.00 3.21 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36230 BP_3 2572.60 27.44 4810 189240719 XP_974316.2 3717 0.0e+00 PREDICTED: TBC1 domain family member 9, partial [Tribolium castaneum] 640785773 XM_008050426.1 160 2.49142e-75 PREDICTED: Tarsius syrichta TBC1 domain family, member 9B (with GRAM domain) (TBC1D9B), transcript variant X2, mRNA -- -- -- -- Q6ZT07 2407 1.0e-269 TBC1 domain family member 9 OS=Homo sapiens GN=TBC1D9 PE=2 SV=2 PF13499//PF13833//PF00036//PF13405//PF10637//PF04840//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Oxoglutarate and iron-dependent oxygenase degradation C-term//Vps16, C-terminal region//EF hand GO:0006886//GO:0055114 intracellular protein transport//oxidation-reduction process GO:0016706//GO:0031418//GO:0005509//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//L-ascorbic acid binding//calcium ion binding//iron ion binding GO:0005737 cytoplasm KOG4347 GTPase-activating protein VRP Cluster-8309.36231 BP_3 8145.00 1696.57 523 264667453 ACY71312.1 407 2.2e-37 ribosomal protein L35 [Chrysomela tremula] 197260765 EU930255.1 75 4.55393e-29 Simulium vittatum clone SV-271 60S ribosomal protein L35 mRNA, complete cds K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 Q69CJ9 276 1.4e-23 60S ribosomal protein L35 OS=Ophiophagus hannah GN=RPL35 PE=2 SV=3 PF00831 Ribosomal L29 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3436 60S ribosomal protein L35 Cluster-8309.36232 BP_3 765.19 34.43 1363 332373426 AEE61854.1 1251 7.7e-135 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14012 SHP1, UBX1, NSFL1C UBX domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14012 Q5ZK10 727 1.8e-75 NSFL1 cofactor p47 OS=Gallus gallus GN=NSFL1C PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG2086 Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion Cluster-8309.36233 BP_3 51.29 3.45 1008 546680237 ERL90555.1 690 6.4e-70 hypothetical protein D910_07903 [Dendroctonus ponderosae] 332373055 BT126707.1 106 5.30678e-46 Dendroctonus ponderosae clone DPO131_P13 unknown mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47947 433 1.7e-41 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF12763//PF13202//PF13499//PF00036//PF13833//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.36234 BP_3 326.06 3.33 5011 91085385 XP_966386.1 455 5.7e-42 PREDICTED: arginine/serine-rich coiled-coil protein 2 [Tribolium castaneum]>gi|270009149|gb|EFA05597.1| hypothetical protein TcasGA2_TC015801 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHJ5 200 8.6e-14 Arginine/serine-rich coiled-coil protein 2 OS=Xenopus tropicalis GN=rsrc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36235 BP_3 17158.63 1387.03 888 264667427 ACY71299.1 985 3.5e-104 ribosomal protein L7A [Chrysomela tremula] 264667426 GU120449.1 275 5.26196e-140 Chrysomela tremulae ribosomal protein L7A (RpL7A) mRNA, complete cds K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P46223 854 2.2e-90 60S ribosomal protein L7a OS=Drosophila melanogaster GN=RpL7A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8309.36236 BP_3 320.83 4.63 3633 642923738 XP_008193865.1 3045 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X7 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 Q9QUJ7 1680 1.5e-185 Long-chain-fatty-acid--CoA ligase 4 OS=Mus musculus GN=Acsl4 PE=2 SV=2 PF00908//PF00501 dTDP-4-dehydrorhamnose 3,5-epimerase//AMP-binding enzyme GO:0009117//GO:0019872//GO:0008152//GO:0030639 nucleotide metabolic process//streptomycin biosynthetic process//metabolic process//polyketide biosynthetic process GO:0003824//GO:0008830 catalytic activity//dTDP-4-dehydrorhamnose 3,5-epimerase activity -- -- KOG1180 Acyl-CoA synthetase Cluster-8309.36238 BP_3 1438.00 22.96 3311 642917356 XP_008199268.1 4321 0.0e+00 PREDICTED: superkiller viralicidic activity 2-like 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12598 MTR4, SKIV2L2 ATP-dependent RNA helicase DOB1 http://www.genome.jp/dbget-bin/www_bget?ko:K12598 Q9CZU3 3161 0.0e+00 Superkiller viralicidic activity 2-like 2 OS=Mus musculus GN=Skiv2l2 PE=1 SV=1 PF00437//PF00270 Type II/IV secretion system protein//DEAD/DEAH box helicase GO:0006810 transport GO:0003676//GO:0005524 nucleic acid binding//ATP binding -- -- KOG0948 Nuclear exosomal RNA helicase MTR4, DEAD-box superfamily Cluster-8309.36239 BP_3 205.46 3.44 3172 91089165 XP_973951.1 493 1.4e-46 PREDICTED: H/ACA ribonucleoprotein complex non-core subunit NAF1 [Tribolium castaneum]>gi|270011488|gb|EFA07936.1| hypothetical protein TcasGA2_TC005517 [Tribolium castaneum] -- -- -- -- -- K14763 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 http://www.genome.jp/dbget-bin/www_bget?ko:K14763 Q9VJ62 316 1.9e-27 H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Drosophila melanogaster GN=CG10341 PE=1 SV=2 PF03153//PF04889//PF04410//PF04931 Transcription factor IIA, alpha/beta subunit//Cwf15/Cwc15 cell cycle control protein//Gar1/Naf1 RNA binding region//DNA polymerase phi GO:0006351//GO:0006260//GO:0042254//GO:0001522//GO:0006367//GO:0000398 transcription, DNA-templated//DNA replication//ribosome biogenesis//pseudouridine synthesis//transcription initiation from RNA polymerase II promoter//mRNA splicing, via spliceosome GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0005681//GO:0042575//GO:0005672 spliceosomal complex//DNA polymerase complex//transcription factor TFIIA complex KOG2236 Uncharacterized conserved protein Cluster-8309.3624 BP_3 10.00 1.21 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115 SFI toxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.36241 BP_3 37.93 0.35 5528 642926415 XP_008191953.1 2954 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X2 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.64162e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 4.1e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.36242 BP_3 375.10 3.31 5746 646705667 KDR13254.1 634 1.1e-62 hypothetical protein L798_12642, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8N184 499 2.1e-48 Zinc finger protein 567 OS=Homo sapiens GN=ZNF567 PE=1 SV=3 PF00096//PF07664//PF07776//PF13465//PF00412//PF13912//PF00122//PF05191//PF16622//PF00320 Zinc finger, C2H2 type//Ferrous iron transport protein B C terminus//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//LIM domain//C2H2-type zinc finger//E1-E2 ATPase//Adenylate kinase, active site lid//zinc-finger C2H2-type//GATA zinc finger GO:0015684//GO:0006355//GO:0046034//GO:0006144 ferrous iron transport//regulation of transcription, DNA-templated//ATP metabolic process//purine nucleobase metabolic process GO:0046872//GO:0004017//GO:0003700//GO:0008270//GO:0000166//GO:0043565//GO:0015093 metal ion binding//adenylate kinase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//nucleotide binding//sequence-specific DNA binding//ferrous iron transmembrane transporter activity GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus -- -- Cluster-8309.36244 BP_3 1180.42 143.21 689 478250947 ENN71431.1 294 3.6e-24 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7X3Z4 148 1.3e-08 C-type lectin lectoxin-Lio1 OS=Erythrolamprus poecilogyrus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36248 BP_3 105283.00 548.29 9547 478263038 ENN81438.1 8441 0.0e+00 hypothetical protein YQE_02131, partial [Dendroctonus ponderosae] 462389649 APGK01019091.1 63 4.14583e-21 Dendroctonus ponderosae Seq01019101, whole genome shotgun sequence -- -- -- -- Q9U943 3480 0.0e+00 Apolipophorins OS=Locusta migratoria PE=1 SV=2 PF01442//PF01347//PF02949//PF09172//PF09074//PF06448//PF08702//PF04513 Apolipoprotein A1/A4/E domain//Lipoprotein amino terminal region//7tm Odorant receptor//Domain of unknown function (DUF1943)//Mer2//Domain of Unknown Function (DUF1081)//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007131//GO:0051258//GO:0007165//GO:0007187//GO:0007608//GO:0030168//GO:0006869//GO:0042157 reciprocal meiotic recombination//protein polymerization//signal transduction//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell//platelet activation//lipid transport//lipoprotein metabolic process GO:0005102//GO:0005549//GO:0005198//GO:0004984//GO:0030674//GO:0005319//GO:0008289 receptor binding//odorant binding//structural molecule activity//olfactory receptor activity//protein binding, bridging//lipid transporter activity//lipid binding GO:0005577//GO:0019028//GO:0016020//GO:0005576//GO:0019031//GO:0000794 fibrinogen complex//viral capsid//membrane//extracellular region//viral envelope//condensed nuclear chromosome -- -- Cluster-8309.36249 BP_3 1373.55 12.42 5623 642915997 XP_008190849.1 4186 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 401 0 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 1237 5.5e-134 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF07714//PF00069//PF06293//PF00041//PF13895//PF16656 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0006468//GO:0019497 riboflavin metabolic process//protein phosphorylation//hexachlorocyclohexane metabolic process GO:0004672//GO:0046872//GO:0016773//GO:0003993//GO:0005515//GO:0005524 protein kinase activity//metal ion binding//phosphotransferase activity, alcohol group as acceptor//acid phosphatase activity//protein binding//ATP binding GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36250 BP_3 11118.00 579.16 1217 589060796 AHK26791.1 1474 9.5e-161 eukaryotic translation initiation factor 4A [Epicauta chinensis] 817197946 XM_012419174.1 283 2.60013e-144 PREDICTED: Orussus abietinus eukaryotic initiation factor 4A-I (LOC105696595), mRNA K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 Q5R4X1 1171 5.3e-127 Eukaryotic initiation factor 4A-II OS=Pongo abelii GN=EIF4A2 PE=2 SV=1 PF04851//PF07652//PF00270 Type III restriction enzyme, res subunit//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0019079 viral genome replication GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0008026 ATP binding//nucleic acid binding//DNA binding//hydrolase activity//ATP-dependent helicase activity -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.36251 BP_3 22.24 0.47 2553 91086105 XP_967675.1 1547 6.8e-169 PREDICTED: long-chain fatty acid transport protein 4-like [Tribolium castaneum] -- -- -- -- -- K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K08745 Q91VE0 1099 2.5e-118 Long-chain fatty acid transport protein 4 OS=Mus musculus GN=Slc27a4 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.36252 BP_3 999.56 7.48 6735 189237751 XP_001812575.1 2460 2.4e-274 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 9.9e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF04769//PF00787//PF08070 Mating-type protein MAT alpha 1 HMG-box//PX domain//DTHCT (NUC029) region GO:0006265//GO:0045895//GO:0007531 DNA topological change//positive regulation of mating-type specific transcription, DNA-templated//mating type determination GO:0008301//GO:0003918//GO:0035091//GO:0003677//GO:0005524 DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity//phosphatidylinositol binding//DNA binding//ATP binding GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.36255 BP_3 1092.13 12.68 4443 91094823 XP_971065.1 3125 0.0e+00 PREDICTED: protein O-mannosyltransferase 1 [Tribolium castaneum] 847169839 XM_002938748.3 97 2.41666e-40 PREDICTED: Xenopus (Silurana) tropicalis proteasome (prosome, macropain) subunit, beta type, 7 (psmb7), mRNA K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q9VTK2 2264 3.5e-253 Protein O-mannosyltransferase 1 OS=Drosophila melanogaster GN=rt PE=2 SV=2 PF02366//PF02815//PF00227 Dolichyl-phosphate-mannose-protein mannosyltransferase//MIR domain//Proteasome subunit GO:0051603//GO:0006493 proteolysis involved in cellular protein catabolic process//protein O-linked glycosylation GO:0004298//GO:0000030 threonine-type endopeptidase activity//mannosyltransferase activity GO:0000136//GO:0016020//GO:0005839 alpha-1,6-mannosyltransferase complex//membrane//proteasome core complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.36256 BP_3 29.04 0.52 2960 264667471 ACY71321.1 794 1.6e-81 ribosomal biogenesis protein RLP24 [Chrysomela tremula] -- -- -- -- -- K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q9VGN9 595 8.0e-60 Probable ribosome biogenesis protein RLP24 OS=Drosophila melanogaster GN=RpL24-like PE=1 SV=1 PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1723 60s ribosomal protein L30 isolog Cluster-8309.36257 BP_3 3472.70 20.96 8276 642920909 XP_008192611.1 8856 0.0e+00 PREDICTED: spectrin beta chain isoform X5 [Tribolium castaneum] 642920908 XM_008194389.1 1881 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7554 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00307//PF00435//PF04728 Calponin homology (CH) domain//Spectrin repeat//Lipoprotein leucine-zipper -- -- GO:0005515 protein binding GO:0019867 outer membrane KOG0517 Beta-spectrin Cluster-8309.36260 BP_3 1418.00 89.66 1054 642934887 XP_008197848.1 1167 3.3e-125 PREDICTED: eukaryotic translation initiation factor 3 subunit G [Tribolium castaneum]>gi|270013801|gb|EFA10249.1| hypothetical protein TcasGA2_TC012449 [Tribolium castaneum] -- -- -- -- -- K03248 EIF3G translation initiation factor 3 subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K03248 Q1HQN4 820 2.3e-86 Eukaryotic translation initiation factor 3 subunit G OS=Aedes aegypti GN=eIF3-S4-1 PE=2 SV=1 PF06220//PF00076 U1 zinc finger//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003676//GO:0000166//GO:0008270 translation initiation factor activity//nucleic acid binding//nucleotide binding//zinc ion binding GO:0005840//GO:0005737 ribosome//cytoplasm KOG0122 Translation initiation factor 3, subunit g (eIF-3g) Cluster-8309.36261 BP_3 38.55 0.60 3402 91094511 XP_971832.1 676 9.1e-68 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.47367e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 Q8VHV7 448 1.0e-42 Heterogeneous nuclear ribonucleoprotein H OS=Rattus norvegicus GN=Hnrnph1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.36262 BP_3 6.08 0.38 1063 91077066 XP_969171.1 844 9.3e-88 PREDICTED: T-complex protein 1 subunit alpha [Tribolium castaneum]>gi|270002029|gb|EEZ98476.1| hypothetical protein TcasGA2_TC000969 [Tribolium castaneum] -- -- -- -- -- K09493 CCT1, TCP1 T-complex protein 1 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K09493 P12613 755 8.0e-79 T-complex protein 1 subunit alpha OS=Drosophila melanogaster GN=T-cp1 PE=2 SV=2 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0005737 cytoplasm KOG0360 Chaperonin complex component, TCP-1 alpha subunit (CCT1) Cluster-8309.36266 BP_3 1488.00 53.79 1625 642917962 XP_008198961.1 790 2.6e-81 PREDICTED: probable phospholipid hydroperoxide glutathione peroxidase [Tribolium castaneum]>gi|270004924|gb|EFA01372.1| hypothetical protein TcasGA2_TC010362 [Tribolium castaneum] -- -- -- -- -- K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q9N2J2 503 2.0e-49 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial OS=Bos taurus GN=GPX4 PE=2 SV=2 PF00255//PF00578//PF08534 Glutathione peroxidase//AhpC/TSA family//Redoxin GO:0006979//GO:0055114//GO:0006804//GO:0006749 response to oxidative stress//oxidation-reduction process//obsolete peroxidase reaction//glutathione metabolic process GO:0016491//GO:0016209//GO:0004602 oxidoreductase activity//antioxidant activity//glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-8309.36267 BP_3 6.00 0.57 797 167444218 ABZ80670.1 471 1.3e-44 i-type lysozyme [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05497 Destabilase GO:0005975 carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-8309.36268 BP_3 15.25 0.47 1847 642912944 XP_008201318.1 854 1.1e-88 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 539 1.6e-53 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36269 BP_3 2529.88 54.24 2540 642938577 XP_008199848.1 2844 0.0e+00 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938579|ref|XP_008199849.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938581|ref|XP_008199850.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938583|ref|XP_008199851.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938585|ref|XP_008199852.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|270015602|gb|EFA12050.1| hypothetical protein TcasGA2_TC001467 [Tribolium castaneum] 642938584 XM_008201630.1 746 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X5, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 Q16720 1872 5.8e-208 Plasma membrane calcium-transporting ATPase 3 OS=Homo sapiens GN=ATP2B3 PE=1 SV=3 PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006754//GO:0070588//GO:0006816 ATP biosynthetic process//calcium ion transmembrane transport//calcium ion transport GO:0046872//GO:0005388//GO:0005524 metal ion binding//calcium-transporting ATPase activity//ATP binding GO:0016529//GO:0016021 sarcoplasmic reticulum//integral component of membrane KOG0204 Calcium transporting ATPase Cluster-8309.36270 BP_3 412.00 52.49 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05790 Immunoglobulin C2-set domain GO:0007155 cell adhesion -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36273 BP_3 585.27 5.23 5682 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 6.20008e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF05201//PF03178 Glutamyl-tRNAGlu reductase, N-terminal domain//CPSF A subunit region GO:0055114//GO:0033014 oxidation-reduction process//tetrapyrrole biosynthetic process GO:0003676//GO:0050661//GO:0008883 nucleic acid binding//NADP binding//glutamyl-tRNA reductase activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.36275 BP_3 5576.53 174.39 1833 642927717 XP_008195380.1 1020 6.3e-108 PREDICTED: ras-like GTP-binding protein Rho1 isoform X1 [Tribolium castaneum] 755932870 XM_011316165.1 162 7.25599e-77 PREDICTED: Fopius arisanus ras-like GTP-binding protein Rho1 (LOC105273622), transcript variant X9, mRNA K04513 RHOA Ras homolog gene family, member A http://www.genome.jp/dbget-bin/www_bget?ko:K04513 P48148 946 9.9e-101 Ras-like GTP-binding protein Rho1 OS=Drosophila melanogaster GN=Rho1 PE=1 SV=1 PF08477//PF00025//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.36276 BP_3 10933.25 644.80 1109 121582324 NP_001073566.1 1159 2.9e-124 cuticular protein analogous to peritrophins 3-B precursor [Tribolium castaneum]>gi|119387886|gb|ABL73928.1| obstractor B [Tribolium castaneum]>gi|270000881|gb|EEZ97328.1| hypothetical protein TcasGA2_TC011139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W5U2 149 1.6e-08 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.36277 BP_3 1881.54 25.80 3807 91082911 XP_972477.1 4248 0.0e+00 PREDICTED: FACT complex subunit spt16 [Tribolium castaneum]>gi|270007613|gb|EFA04061.1| hypothetical protein TcasGA2_TC014294 [Tribolium castaneum] 817053620 XM_012407564.1 485 0 PREDICTED: Athalia rosae FACT complex subunit spt16 (LOC105690057), transcript variant X2, mRNA -- -- -- -- Q8IRG6 3463 0.0e+00 FACT complex subunit spt16 OS=Drosophila melanogaster GN=dre4 PE=1 SV=2 PF02499 Probable DNA packing protein, C-terminus GO:0006323//GO:0009987 DNA packaging//cellular process -- -- -- -- KOG1189 Global transcriptional regulator, cell division control protein Cluster-8309.36278 BP_3 740.00 49.52 1012 332374942 AEE62612.1 738 1.7e-75 unknown [Dendroctonus ponderosae]>gi|546684327|gb|ERL94032.1| hypothetical protein D910_11315 [Dendroctonus ponderosae] -- -- -- -- -- K03687 GRPE molecular chaperone GrpE http://www.genome.jp/dbget-bin/www_bget?ko:K03687 Q99LP6 518 2.3e-51 GrpE protein homolog 1, mitochondrial OS=Mus musculus GN=Grpel1 PE=1 SV=1 PF01025//PF08996//PF06156 GrpE//DNA Polymerase alpha zinc finger//Protein of unknown function (DUF972) GO:0006260//GO:0006457 DNA replication//protein folding GO:0001882//GO:0051087//GO:0042803//GO:0000774//GO:0003887 nucleoside binding//chaperone binding//protein homodimerization activity//adenyl-nucleotide exchange factor activity//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG3003 Molecular chaperone of the GrpE family Cluster-8309.36279 BP_3 11974.94 1201.78 772 91079322 XP_968042.1 717 3.6e-73 PREDICTED: 60S ribosomal protein L18 [Tribolium castaneum]>gi|270004338|gb|EFA00786.1| hypothetical protein TcasGA2_TC003672 [Tribolium castaneum] 70909738 AM049056.1 269 9.843e-137 Timarcha balearica mRNA for ribosomal protein L18e (rpL18e gene) K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q4GXG7 719 8.7e-75 60S ribosomal protein L18 OS=Timarcha balearica GN=RpL18 PE=2 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1714 60s ribosomal protein L18 Cluster-8309.36280 BP_3 55.84 1.56 2012 642939029 XP_008200194.1 621 1.3e-61 PREDICTED: uncharacterized protein LOC103314860 [Tribolium castaneum]>gi|270016275|gb|EFA12721.1| hypothetical protein TcasGA2_TC002356 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D722 128 7.7e-06 Oxidative stress-responsive serine-rich protein 1 OS=Mus musculus GN=Oser1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36281 BP_3 48.00 2.50 1218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36283 BP_3 273.46 10.37 1563 189235535 XP_972604.2 1850 3.1e-204 PREDICTED: cAMP-dependent protein kinase type I regulatory subunit isoform X1 [Tribolium castaneum]>gi|270003022|gb|EEZ99469.1| hypothetical protein TcasGA2_TC000040 [Tribolium castaneum] 817195912 XM_012418094.1 263 4.41001e-133 PREDICTED: Orussus abietinus cAMP-dependent protein kinase type I regulatory subunit (LOC105695993), transcript variant X1, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P16905 1582 1.5e-174 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- GO:0045859//GO:0007165//GO:0001932 regulation of protein kinase activity//signal transduction//regulation of protein phosphorylation GO:0008603 cAMP-dependent protein kinase regulator activity GO:0005952 cAMP-dependent protein kinase complex KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.36284 BP_3 99.49 1.61 3264 478262395 ENN81066.1 2397 2.4e-267 hypothetical protein YQE_02435, partial [Dendroctonus ponderosae]>gi|546673615|gb|ERL85179.1| hypothetical protein D910_02601 [Dendroctonus ponderosae] 807040070 XM_004535125.2 125 4.81827e-56 PREDICTED: Ceratitis capitata plastin-3 (LOC101457045), transcript variant X2, mRNA K17336 PLS3 plastin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K17336 P13796 1297 3.5e-141 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=6 PF00036//PF13833//PF13405//PF13499//PF00307//PF13202//PF04608 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Calponin homology (CH) domain//EF hand//Phosphatidylglycerophosphatase A GO:0046486//GO:0006629 glycerolipid metabolic process//lipid metabolic process GO:0005509//GO:0005515//GO:0008962 calcium ion binding//protein binding//phosphatidylglycerophosphatase activity -- -- KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily Cluster-8309.36286 BP_3 69.07 1.71 2235 642912272 XP_008200632.1 483 1.4e-45 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88947 148 4.1e-08 Coagulation factor X OS=Mus musculus GN=F10 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.36287 BP_3 113.00 6.89 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36289 BP_3 2541.77 16.26 7828 642927067 XP_008195123.1 5796 0.0e+00 PREDICTED: protein RIC1 homolog [Tribolium castaneum] 698415894 XM_009696085.1 54 3.42056e-16 PREDICTED: Cariama cristata RAB6A GEF complex partner 1 (RIC1), partial mRNA -- -- -- -- Q9V3C5 2693 1.1e-302 Guanine nucleotide exchange factor subunit Rich OS=Drosophila melanogaster GN=Rich PE=1 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG2006 WD40 repeat protein Cluster-8309.36290 BP_3 941.00 52.00 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708//PF10384 Geminivirus putative movement protein//Centromere protein Scm3 GO:0046740 transport of virus in host, cell to cell GO:0042393 histone binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.36291 BP_3 222.11 21.70 785 642918417 XP_008191464.1 792 7.4e-82 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X2 [Tribolium castaneum] 462383650 APGK01021187.1 59 5.48363e-20 Dendroctonus ponderosae Seq01021197, whole genome shotgun sequence K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 Q63704 599 7.3e-61 Carnitine O-palmitoyltransferase 1, muscle isoform OS=Rattus norvegicus GN=Cpt1b PE=1 SV=1 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3716 Carnitine O-acyltransferase CPTI Cluster-8309.36292 BP_3 51103.00 1572.61 1858 91080053 XP_973257.1 1304 7.5e-141 PREDICTED: ADP,ATP carrier protein 1 [Tribolium castaneum]>gi|270003211|gb|EEZ99658.1| hypothetical protein TcasGA2_TC002415 [Tribolium castaneum] -- -- -- -- -- K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q27238 1246 1.6e-135 ADP,ATP carrier protein 1 OS=Anopheles gambiae GN=AGAP006782 PE=2 SV=2 -- -- GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.36293 BP_3 291.17 1.44 10068 91088249 XP_966392.1 4206 0.0e+00 PREDICTED: myosin-IA [Tribolium castaneum]>gi|270011817|gb|EFA08265.1| hypothetical protein TcasGA2_TC005895 [Tribolium castaneum] 573901209 XM_006638269.1 110 3.26302e-47 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 3028 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF00612//PF00063//PF06414//PF00437//PF06017 IQ calmodulin-binding motif//Myosin head (motor domain)//Zeta toxin//Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding GO:0006810 transport GO:0005515//GO:0005524//GO:0016301//GO:0003774 protein binding//ATP binding//kinase activity//motor activity GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.36294 BP_3 2964.65 58.25 2745 642911547 XP_974187.2 904 2.7e-94 PREDICTED: uncharacterized protein LOC663029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54715 152 1.7e-08 V-type proton ATPase subunit S1 OS=Rattus norvegicus GN=Atp6ap1 PE=2 SV=1 PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.36295 BP_3 1221.00 69.13 1143 283046834 NP_001164360.1 1256 1.7e-135 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [Tribolium castaneum]>gi|270014261|gb|EFA10709.1| hypothetical protein TcasGA2_TC011988 [Tribolium castaneum] 255721638 XM_002545708.1 76 2.87152e-29 Candida tropicalis MYA-3404 succinate dehydrogenase iron-sulfur protein, mitochondrial precursor, mRNA K00235 SDHB, SDH2 succinate dehydrogenase (ubiquinone) iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00235 P21914 1096 2.5e-118 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Drosophila melanogaster GN=SdhB PE=2 SV=2 PF00111//PF13085//PF09788 2Fe-2S iron-sulfur cluster binding domain//2Fe-2S iron-sulfur cluster binding domain//Transmembrane protein 55A GO:0006099//GO:0006118//GO:0046856 tricarboxylic acid cycle//obsolete electron transport//phosphatidylinositol dephosphorylation GO:0034597//GO:0009055//GO:0051536//GO:0016491//GO:0051537 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//electron carrier activity//iron-sulfur cluster binding//oxidoreductase activity//2 iron, 2 sulfur cluster binding -- -- KOG3049 Succinate dehydrogenase, Fe-S protein subunit Cluster-8309.36296 BP_3 12.00 0.40 1749 291170322 ADD82417.1 224 1.2e-15 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.36297 BP_3 2780.29 60.19 2518 546684212 ERL93917.1 756 3.5e-77 hypothetical protein D910_11203 [Dendroctonus ponderosae] -- -- -- -- -- K03258 EIF4B translation initiation factor 4B http://www.genome.jp/dbget-bin/www_bget?ko:K03258 P23588 390 4.0e-36 Eukaryotic translation initiation factor 4B OS=Homo sapiens GN=EIF4B PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.36298 BP_3 2994.23 39.47 3948 -- -- -- -- -- 642922275 XM_001814946.2 56 1.32814e-17 PREDICTED: Tribolium castaneum glycine-rich cell wall structural protein 1.8 (LOC100142484), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF01853 MOZ/SAS family GO:0006355 regulation of transcription, DNA-templated GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.36299 BP_3 1326.33 40.12 1885 478262394 ENN81065.1 797 4.7e-82 hypothetical protein YQE_02434, partial [Dendroctonus ponderosae]>gi|546673614|gb|ERL85178.1| hypothetical protein D910_02600 [Dendroctonus ponderosae] -- -- -- -- -- K16365 SGTA small glutamine-rich tetratricopeptide repeat-containing protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16365 O43765 485 2.9e-47 Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens GN=SGTA PE=1 SV=1 PF13176//PF13174//PF13414//PF13374//PF00515//PF13181//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0553 TPR repeat-containing protein Cluster-8309.36300 BP_3 16.63 0.59 1647 642923845 XP_008193902.1 716 1.0e-72 PREDICTED: uncharacterized protein LOC662374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03530 Calcium-activated SK potassium channel GO:0006813 potassium ion transport GO:0016286 small conductance calcium-activated potassium channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.36301 BP_3 1572.22 67.89 1408 156481748 ABU68467.1 1398 7.1e-152 adenine nucleotide translocase [Monochamus alternatus] 156481747 EU093076.1 880 0 Monochamus alternatus adenine nucleotide translocase mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q26365 1264 1.0e-137 ADP,ATP carrier protein OS=Drosophila melanogaster GN=sesB PE=2 SV=4 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.36305 BP_3 126.10 0.86 7363 478262392 ENN81063.1 5910 0.0e+00 hypothetical protein YQE_02432, partial [Dendroctonus ponderosae] 642911110 XM_008202361.1 1052 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA K12567 TTN titin http://www.genome.jp/dbget-bin/www_bget?ko:K12567 Q23551 3022 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF16656//PF02480//PF00041//PF13895//PF16794//PF03739//PF01108 Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Fibronectin type III domain//Immunoglobulin domain//Fibronectin-III type domain//Predicted permease YjgP/YjgQ family//Tissue factor GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36306 BP_3 13520.64 235.07 3064 58294539 AAW70172.1 3372 0.0e+00 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 1253 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 2258 1.2e-252 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.36308 BP_3 62.06 0.57 5547 478250717 ENN71209.1 490 5.5e-46 hypothetical protein YQE_12138, partial [Dendroctonus ponderosae]>gi|546678600|gb|ERL89182.1| hypothetical protein D910_06556 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344//PF08053//PF05497 Kelch motif//Tryptophanase operon leader peptide//Destabilase GO:0005975//GO:0031554//GO:0031556 carbohydrate metabolic process//regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome GO:0005515//GO:0003796 protein binding//lysozyme activity -- -- -- -- Cluster-8309.36309 BP_3 3291.00 40.78 4181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08136 30S ribosomal protein subunit S22 family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.36310 BP_3 1563.00 54.62 1671 91092724 XP_972731.1 1485 6.9e-162 PREDICTED: uncharacterized protein LOC661483 [Tribolium castaneum]>gi|270014877|gb|EFA11325.1| hypothetical protein TcasGA2_TC010864 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36311 BP_3 6816.45 484.40 970 91091966 XP_967128.1 1175 3.6e-126 PREDICTED: tropomyosin-1 [Tribolium castaneum]>gi|270001148|gb|EEZ97595.1| hypothetical protein TcasGA2_TC011461 [Tribolium castaneum] 724090708 KM396883.1 616 0 Monochamus alternatus tropomyosin-1 mRNA, partial cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPU0 1098 1.2e-118 Tropomyosin-1 OS=Bombyx mori PE=1 SV=1 PF07926//PF04728//PF08702//PF06009//PF07851//PF06008//PF01496//PF10392//PF13851//PF05739//PF10473//PF06160//PF00015//PF00769//PF07928//PF04111//PF04048//PF16716//PF10186//PF09730 TPR/MLP1/MLP2-like protein//Lipoprotein leucine-zipper//Fibrinogen alpha/beta chain family//Laminin Domain II//TMPIT-like protein//Laminin Domain I//V-type ATPase 116kDa subunit family//Golgi transport complex subunit 5//Growth-arrest specific micro-tubule binding//SNARE domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Methyl-accepting chemotaxis protein (MCP) signalling domain//Ezrin/radixin/moesin family//Vps54-like protein//Autophagy protein Apg6//Sec8 exocyst complex component specific domain//Bone marrow stromal antigen 2//Vacuolar sorting 38 and autophagy-related subunit 14//Microtubule-associated protein Bicaudal-D GO:0051607//GO:0015991//GO:0007155//GO:0030155//GO:0051258//GO:0006914//GO:0006810//GO:0007165//GO:0030334//GO:0010508//GO:0015031//GO:0006904//GO:0048870//GO:0000921//GO:0006891//GO:0030168//GO:0015992//GO:0042147//GO:0045995//GO:0006606 defense response to virus//ATP hydrolysis coupled proton transport//cell adhesion//regulation of cell adhesion//protein polymerization//autophagy//transport//signal transduction//regulation of cell migration//positive regulation of autophagy//protein transport//vesicle docking involved in exocytosis//cell motility//septin ring assembly//intra-Golgi vesicle-mediated transport//platelet activation//proton transport//retrograde transport, endosome to Golgi//regulation of embryonic development//protein import into nucleus GO:0005515//GO:0042803//GO:0004871//GO:0015078//GO:0008092//GO:0030674//GO:0008134//GO:0045502//GO:0005102 protein binding//protein homodimerization activity//signal transducer activity//hydrogen ion transmembrane transporter activity//cytoskeletal protein binding//protein binding, bridging//transcription factor binding//dynein binding//receptor binding GO:0019867//GO:0033179//GO:0000145//GO:0017119//GO:0016020//GO:0005940//GO:0016021//GO:0031514//GO:0005737//GO:0005667//GO:0030286//GO:0005794//GO:0019898//GO:0005577 outer membrane//proton-transporting V-type ATPase, V0 domain//exocyst//Golgi transport complex//membrane//septin ring//integral component of membrane//motile cilium//cytoplasm//transcription factor complex//dynein complex//Golgi apparatus//extrinsic component of membrane//fibrinogen complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.36312 BP_3 189.49 4.31 2410 568253794 ETN62859.1 2234 1.4e-248 Elongation factor 1-alpha 2 [Anopheles darlingi] 727098916 KJ534557.1 786 0 Colaphellus bowringi elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P05303 2201 3.9e-246 Elongation factor 1-alpha 2 OS=Drosophila melanogaster GN=Ef1alpha100E PE=2 SV=2 PF03144//PF02615//PF01926 Elongation factor Tu domain 2//Malate/L-lactate dehydrogenase//50S ribosome-binding GTPase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0005525//GO:0016491 GTP binding//oxidoreductase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.36315 BP_3 1371.85 20.26 3555 642936487 XP_008198457.1 2347 1.6e-261 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.3582e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1251 8.2e-136 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF01699//PF00060//PF10613//PF05699 Sodium/calcium exchanger protein//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//hAT family C-terminal dimerisation region GO:0055085//GO:0007165//GO:0007268//GO:0006811 transmembrane transport//signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970//GO:0046983//GO:0005216 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//protein dimerization activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.36317 BP_3 862.74 15.49 2976 642910216 XP_008198443.1 2351 4.7e-262 PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum]>gi|642910218|ref|XP_967637.2| PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum] 642910217 XM_962544.2 492 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC655987), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 P49802 1458 6.9e-160 Regulator of G-protein signaling 7 OS=Homo sapiens GN=RGS7 PE=1 SV=3 PF00610//PF00631 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//GGL domain GO:0007186//GO:0007165//GO:0035556 G-protein coupled receptor signaling pathway//signal transduction//intracellular signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex KOG3589 G protein signaling regulators Cluster-8309.3632 BP_3 30.00 1.01 1720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36320 BP_3 245.83 12.71 1224 60300016 AAX18656.1 151 2.5e-07 cysteine-rich protein [Apriona germari] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36321 BP_3 13547.00 3718.77 467 389608135 BAM17679.1 323 1.1e-27 ribosomal protein LP2 [Papilio xuthus]>gi|389610557|dbj|BAM18890.1| ribosomal protein LP2 [Papilio polytes] -- -- -- -- -- K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P05389 281 3.2e-24 60S acidic ribosomal protein P2 OS=Drosophila melanogaster GN=RpLP2 PE=1 SV=1 PF13184 NusA-like KH domain -- -- GO:0003723 RNA binding -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-8309.36322 BP_3 125.17 2.16 3086 58294539 AAW70172.1 3372 0.0e+00 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 1253 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 2258 1.2e-252 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006879//GO:0006826 cellular iron ion homeostasis//iron ion transport GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.36323 BP_3 13.90 0.39 1997 728416984 AIY68330.1 1261 7.8e-136 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 P35502 612 5.8e-62 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.36324 BP_3 72.04 4.19 1120 642911969 XP_008199043.1 634 2.2e-63 PREDICTED: elongation factor 1-delta isoform X2 [Tribolium castaneum] -- -- -- -- -- K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 Q9VL18 446 5.7e-43 Probable elongation factor 1-delta OS=Drosophila melanogaster GN=eEF1delta PE=1 SV=1 PF08702//PF02346//PF00736//PF10152 Fibrinogen alpha/beta chain family//Chordopoxvirus multifunctional envelope protein A27//EF-1 guanine nucleotide exchange domain//Predicted coiled-coil domain-containing protein (DUF2360) GO:0006448//GO:0051258//GO:0019064//GO:0006414//GO:0007165//GO:0030168 regulation of translational elongation//protein polymerization//fusion of virus membrane with host plasma membrane//translational elongation//signal transduction//platelet activation GO:0030674//GO:0005102//GO:0003746 protein binding, bridging//receptor binding//translation elongation factor activity GO:0019031//GO:0071203//GO:0005577//GO:0005853//GO:0005840 viral envelope//WASH complex//fibrinogen complex//eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.36325 BP_3 25.88 0.31 4304 546683575 ERL93373.1 1505 8.6e-164 hypothetical protein D910_10665 [Dendroctonus ponderosae] 642921542 XM_970634.3 225 1.63866e-111 PREDICTED: Tribolium castaneum uncharacterized LOC655573 (LOC655573), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36327 BP_3 475.25 11.75 2241 642911471 XP_008199437.1 1821 1.0e-200 PREDICTED: LOW QUALITY PROTEIN: dihydropyrimidinase [Tribolium castaneum] 762124057 XM_011446728.1 87 4.38312e-35 PREDICTED: Crassostrea gigas dihydropyrimidinase-like (LOC105340590), transcript variant X7, mRNA K01464 DPYS, dht, hydA dihydropyrimidinase http://www.genome.jp/dbget-bin/www_bget?ko:K01464 Q63150 1134 1.9e-122 Dihydropyrimidinase OS=Rattus norvegicus GN=Dpys PE=1 SV=2 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG2584 Dihydroorotase and related enzymes Cluster-8309.36329 BP_3 206.72 2.53 4232 642914748 XP_008190336.1 5332 0.0e+00 PREDICTED: potassium channel subfamily T member 2 [Tribolium castaneum] 642914747 XM_008192114.1 1137 0 PREDICTED: Tribolium castaneum potassium channel subfamily T member 2 (LOC655919), mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q8QFV0 1603 1.5e-176 Potassium channel subfamily T member 1 OS=Gallus gallus GN=KCNT1 PE=2 SV=1 PF01022//PF03493//PF00520 Bacterial regulatory protein, arsR family//Calcium-activated BK potassium channel alpha subunit//Ion transport protein GO:0006355//GO:0006811//GO:0055085//GO:0006813 regulation of transcription, DNA-templated//ion transport//transmembrane transport//potassium ion transport GO:0005216//GO:0003700//GO:0015269 ion channel activity//transcription factor activity, sequence-specific DNA binding//calcium-activated potassium channel activity GO:0016020//GO:0005667 membrane//transcription factor complex KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.36330 BP_3 41330.00 2620.25 1052 556505471 YP_008757568.1 1040 1.7e-110 NADH dehydrogenase subunit 1 (mitochondrion) [Batocera lineolata]>gi|359294294|gb|AEV21663.1| NADH dehydrogenase subunit 1 [Batocera lineolata] 359294281 JN986793.1 731 0 Batocera lineolata mitochondrion, complete genome K03878 ND1 NADH-ubiquinone oxidoreductase chain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03878 B0FWD8 849 1.0e-89 NADH-ubiquinone oxidoreductase chain 1 OS=Aedes aegypti GN=mt:ND1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4770 NADH dehydrogenase subunit 1 Cluster-8309.36331 BP_3 1619.28 13.75 5968 642938243 XP_008198126.1 1652 1.1e-180 PREDICTED: serine/threonine-protein kinase Doa isoform X1 [Tribolium castaneum] 642938246 XM_008199906.1 405 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 1386 3.1e-151 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF10399//PF07714//PF06553//PF00069//PF05445 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//Protein tyrosine kinase//BNIP3//Protein kinase domain//Poxvirus serine/threonine protein kinase GO:0006118//GO:0043065//GO:0015992//GO:0055114//GO:0006119//GO:0006468 obsolete electron transport//positive regulation of apoptotic process//proton transport//oxidation-reduction process//oxidative phosphorylation//protein phosphorylation GO:0004672//GO:0005524//GO:0008121 protein kinase activity//ATP binding//ubiquinol-cytochrome-c reductase activity GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane KOG0671 LAMMER dual specificity kinases Cluster-8309.36332 BP_3 322.00 3.74 4439 91087187 XP_975429.1 1334 5.9e-144 PREDICTED: la-related protein 6 [Tribolium castaneum]>gi|270009568|gb|EFA06016.1| hypothetical protein TcasGA2_TC008844 [Tribolium castaneum] -- -- -- -- -- K18733 LARP6 la-related protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18733 Q9BRS8 386 2.1e-35 La-related protein 6 OS=Homo sapiens GN=LARP6 PE=1 SV=1 PF00076//PF08336 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0006525//GO:0018401//GO:0006560//GO:0055114 arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//proline metabolic process//oxidation-reduction process GO:0004656//GO:0016702//GO:0003676 procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//nucleic acid binding GO:0005783 endoplasmic reticulum KOG1855 Predicted RNA-binding protein Cluster-8309.36333 BP_3 11762.00 294.92 2214 86515394 NP_001034522.1 2725 1.5e-305 pro-phenol oxidase subunit 2 [Tribolium castaneum]>gi|70999576|gb|AAX84205.1| pro-phenol oxidase subunit 2 [Tribolium castaneum] 195585904 XM_002082683.1 49 5.76127e-14 Drosophila simulans GD11733 (Dsim\GD11733), mRNA -- -- -- -- Q9V521 2233 6.9e-250 Phenoloxidase 2 OS=Drosophila melanogaster GN=PPO2 PE=1 SV=1 PF00264 Common central domain of tyrosinase GO:0006118//GO:0006771//GO:0055114//GO:0009805//GO:0008152//GO:0009811//GO:0009821//GO:0009809//GO:0006570 obsolete electron transport//riboflavin metabolic process//oxidation-reduction process//coumarin biosynthetic process//metabolic process//stilbene biosynthetic process//alkaloid biosynthetic process//lignin biosynthetic process//tyrosine metabolic process GO:0004503//GO:0016491//GO:0004097 monophenol monooxygenase activity//oxidoreductase activity//catechol oxidase activity -- -- -- -- Cluster-8309.36334 BP_3 123.85 15.53 676 642913220 XP_008201444.1 269 2.8e-21 PREDICTED: inducible metalloproteinase inhibitor protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82176 206 2.3e-15 Inducible metalloproteinase inhibitor protein OS=Galleria mellonella GN=IMPI PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36335 BP_3 105.87 3.10 1938 642934812 XP_008197820.1 552 1.2e-53 PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934814|ref|XP_008197821.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934816|ref|XP_008197822.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934818|ref|XP_008197823.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum] -- -- -- -- -- K17555 PPP1R14B protein phosphatase 1 regulatory subunit 14B http://www.genome.jp/dbget-bin/www_bget?ko:K17555 -- -- -- -- PF05361 PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation -- -- GO:0005737 cytoplasm -- -- Cluster-8309.36336 BP_3 441.00 12.93 1936 478257905 ENN78045.1 806 4.3e-83 hypothetical protein YQE_05482, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H3L0 251 4.1e-20 Methylmalonic aciduria and homocystinuria type D protein, mitochondrial OS=Homo sapiens GN=MMADHC PE=1 SV=2 PF10229 Uncharacterized conserved protein (DUF2246) GO:0009235 cobalamin metabolic process -- -- -- -- KOG3994 Uncharacterized conserved protein Cluster-8309.36338 BP_3 4824.03 181.61 1572 91077022 XP_976032.1 650 4.3e-65 PREDICTED: uncharacterized protein LOC655336 [Tribolium castaneum]>gi|270001753|gb|EEZ98200.1| hypothetical protein TcasGA2_TC000630 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36339 BP_3 4.68 0.90 541 529172383 BAN67667.1 141 1.6e-06 riptocin [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q27905 141 6.5e-08 Probable antibacterial peptide polyprotein OS=Riptortus clavatus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3634 BP_3 29.57 4.18 633 642936195 XP_008198341.1 391 1.9e-35 PREDICTED: sp-like zinc finger transcription factor isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36340 BP_3 763.10 4.83 7906 546677249 ERL88118.1 2766 9.3e-310 hypothetical protein D910_05507 [Dendroctonus ponderosae] 642931318 XM_008198308.1 1005 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X30, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2646 3.2e-297 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF07926//PF07259//PF08702//PF00038//PF02601//PF16331//PF16326//PF06009//PF00957//PF04977//PF07352//PF08597//PF00517//PF00487//PF06160//PF05557//PF17060//PF06657//PF11382//PF04111//PF04108//PF16716//PF10186//PF01576 TPR/MLP1/MLP2-like protein//ProSAAS precursor//Fibrinogen alpha/beta chain family//Intermediate filament protein//Exonuclease VII, large subunit//TolA binding protein trimerisation//ABC transporter C-terminal domain//Laminin Domain II//Synaptobrevin//Septum formation initiator//Bacteriophage Mu Gam like protein//Translation initiation factor eIF3 subunit//Retroviral envelope protein//Fatty acid desaturase//Septation ring formation regulator, EzrA//Mitotic checkpoint protein//Monopolar spindle protein 2//Centrosome microtubule-binding domain of Cep57//Copper transport outer membrane protein, MctB//Autophagy protein Apg6//Autophagy protein Apg17//Bone marrow stromal antigen 2//Vacuolar sorting 38 and autophagy-related subunit 14//Myosin tail GO:0010508//GO:0007049//GO:0070206//GO:0006810//GO:0016192//GO:0006914//GO:0010951//GO:0051258//GO:0007165//GO:0006308//GO:0007094//GO:0071988//GO:0007155//GO:0006629//GO:0051607//GO:0006606//GO:0030168//GO:0006446//GO:0000921//GO:0030474//GO:0042262 positive regulation of autophagy//cell cycle//protein trimerization//transport//vesicle-mediated transport//autophagy//negative regulation of endopeptidase activity//protein polymerization//signal transduction//DNA catabolic process//mitotic spindle assembly checkpoint//protein localization to spindle pole body//cell adhesion//lipid metabolic process//defense response to virus//protein import into nucleus//platelet activation//regulation of translational initiation//septin ring assembly//spindle pole body duplication//DNA protection GO:0005198//GO:0003690//GO:0008017//GO:0008855//GO:0003677//GO:0005102//GO:0003743//GO:0003774//GO:0030674//GO:0004866 structural molecule activity//double-stranded DNA binding//microtubule binding//exodeoxyribonuclease VII activity//DNA binding//receptor binding//translation initiation factor activity//motor activity//protein binding, bridging//endopeptidase inhibitor activity GO:0005737//GO:0005840//GO:0005940//GO:0016459//GO:0016021//GO:0005852//GO:0019031//GO:0005577//GO:0009318//GO:0045298//GO:0005882 cytoplasm//ribosome//septin ring//myosin complex//integral component of membrane//eukaryotic translation initiation factor 3 complex//viral envelope//fibrinogen complex//exodeoxyribonuclease VII complex//tubulin complex//intermediate filament -- -- Cluster-8309.36341 BP_3 31.35 0.40 4053 332376933 AEE63606.1 1622 2.2e-177 unknown [Dendroctonus ponderosae] 827538802 XM_012696885.1 74 1.34463e-27 PREDICTED: Bombyx mori phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (LOC101743489), transcript variant X3, mRNA K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 Q01604 1393 3.2e-152 Phosphoglycerate kinase OS=Drosophila melanogaster GN=Pgk PE=2 SV=2 PF00162//PF00069//PF01645 Phosphoglycerate kinase//Protein kinase domain//Conserved region in glutamate synthase GO:0055114//GO:0006094//GO:0015976//GO:0006468//GO:0016310//GO:0006096//GO:0006537 oxidation-reduction process//gluconeogenesis//carbon utilization//protein phosphorylation//phosphorylation//glycolytic process//glutamate biosynthetic process GO:0015930//GO:0004672//GO:0016638//GO:0004618//GO:0005524 glutamate synthase activity//protein kinase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//phosphoglycerate kinase activity//ATP binding -- -- KOG1367 3-phosphoglycerate kinase Cluster-8309.36342 BP_3 5341.30 197.39 1596 270010228 EFA06676.1 507 1.7e-48 hypothetical protein TcasGA2_TC009606 [Tribolium castaneum] 366039975 NM_001256069.1 175 3.73809e-84 Tribolium castaneum ornithine decarboxylase antizyme az (az), mRNA K16548 OAZ1 ornithine decarboxylase antizyme 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16548 P54368 177 1.3e-11 Ornithine decarboxylase antizyme 1 OS=Homo sapiens GN=OAZ1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36343 BP_3 9564.38 414.84 1403 332376705 AEE63492.1 591 2.7e-58 unknown [Dendroctonus ponderosae] 332376704 BT128535.1 264 1.09776e-133 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 467 2.6e-45 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF09416 Troponin//RNA helicase (UPF2 interacting domain) GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0003677//GO:0004386//GO:0008270//GO:0005524 DNA binding//helicase activity//zinc ion binding//ATP binding GO:0005737//GO:0005861 cytoplasm//troponin complex KOG3977 Troponin I Cluster-8309.36345 BP_3 11678.94 66.58 8746 478250666 ENN71158.1 3127 0.0e+00 hypothetical protein YQE_12088, partial [Dendroctonus ponderosae] 642931311 XM_001813763.2 1453 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X26, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2919 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00487//PF09177//PF00322//PF07926//PF00038//PF00769//PF08702//PF04111//PF04977//PF00612//PF08375//PF01496//PF01576 Fatty acid desaturase//Syntaxin 6, N-terminal//Endothelin family//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Autophagy protein Apg6//Septum formation initiator//IQ calmodulin-binding motif//Proteasome regulatory subunit C-terminal//V-type ATPase 116kDa subunit family//Myosin tail GO:0048193//GO:0006629//GO:0015991//GO:0030168//GO:0007165//GO:0019229//GO:0006914//GO:0051258//GO:0006606//GO:0042176//GO:0015992//GO:0007049 Golgi vesicle transport//lipid metabolic process//ATP hydrolysis coupled proton transport//platelet activation//signal transduction//regulation of vasoconstriction//autophagy//protein polymerization//protein import into nucleus//regulation of protein catabolic process//proton transport//cell cycle GO:0008092//GO:0005515//GO:0003774//GO:0030674//GO:0005198//GO:0015078//GO:0005102//GO:0030234 cytoskeletal protein binding//protein binding//motor activity//protein binding, bridging//structural molecule activity//hydrogen ion transmembrane transporter activity//receptor binding//enzyme regulator activity GO:0016020//GO:0005576//GO:0033179//GO:0016459//GO:0019898//GO:0005882//GO:0000502//GO:0005577//GO:0005737 membrane//extracellular region//proton-transporting V-type ATPase, V0 domain//myosin complex//extrinsic component of membrane//intermediate filament//proteasome complex//fibrinogen complex//cytoplasm -- -- Cluster-8309.36346 BP_3 105.84 0.97 5539 699049757 AIU39233.1 742 3.3e-75 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 560 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 691 1.1e-70 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF10186//PF03577//PF15898//PF00769//PF11365//PF10473//PF05739//PF06160//PF14073//PF07851//PF16326//PF06009//PF02601//PF04513//PF08702//PF07926 Vacuolar sorting 38 and autophagy-related subunit 14//Peptidase family C69//cGMP-dependent protein kinase interacting domain//Ezrin/radixin/moesin family//Protein of unknown function (DUF3166)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Septation ring formation regulator, EzrA//Centrosome localisation domain of Cep57//TMPIT-like protein//ABC transporter C-terminal domain//Laminin Domain II//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//TPR/MLP1/MLP2-like protein GO:0006308//GO:0007155//GO:0051258//GO:0007165//GO:0010508//GO:0000921//GO:0030168//GO:0006508//GO:0010506//GO:0006606 DNA catabolic process//cell adhesion//protein polymerization//signal transduction//positive regulation of autophagy//septin ring assembly//platelet activation//proteolysis//regulation of autophagy//protein import into nucleus GO:0005515//GO:0008855//GO:0003677//GO:0042802//GO:0043015//GO:0042803//GO:0005198//GO:0016805//GO:0019901//GO:0008092//GO:0030674//GO:0045502//GO:0008134//GO:0005102 protein binding//exodeoxyribonuclease VII activity//DNA binding//identical protein binding//gamma-tubulin binding//protein homodimerization activity//structural molecule activity//dipeptidase activity//protein kinase binding//cytoskeletal protein binding//protein binding, bridging//dynein binding//transcription factor binding//receptor binding GO:0019031//GO:0005940//GO:0016021//GO:0005737//GO:0005667//GO:0030286//GO:0045298//GO:0019898//GO:0019028//GO:0005577//GO:0005615//GO:0009318 viral envelope//septin ring//integral component of membrane//cytoplasm//transcription factor complex//dynein complex//tubulin complex//extrinsic component of membrane//viral capsid//fibrinogen complex//extracellular space//exodeoxyribonuclease VII complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.36349 BP_3 109.91 4.44 1484 642916569 XP_008191733.1 301 1.2e-24 PREDICTED: uncharacterized protein LOC103312564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3635 BP_3 38.31 0.58 3465 642920188 XP_008192240.1 4366 0.0e+00 PREDICTED: lutropin-choriogonadotropic hormone receptor isoform X2 [Tribolium castaneum] -- -- -- -- -- K08399 LGR6 leucine-rich repeat-containing G protein-coupled receptor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08399 Q90674 896 1.2e-94 Lutropin-choriogonadotropic hormone receptor OS=Gallus gallus GN=LHCGR PE=2 SV=2 PF00001//PF00560//PF13855 7 transmembrane receptor (rhodopsin family)//Leucine Rich Repeat//Leucine rich repeat GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016021 integral component of membrane KOG2087 Glycoprotein hormone receptor Cluster-8309.36351 BP_3 262.63 7.71 1934 642925292 XP_001814214.2 1104 1.2e-117 PREDICTED: uncharacterized protein LOC100142468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36352 BP_3 5041.77 90.90 2965 91082223 XP_975988.1 1735 1.3e-190 PREDICTED: four and a half LIM domains protein 2 isoform X5 [Tribolium castaneum] 642922338 XM_970895.3 496 0 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X5, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 1001 6.7e-107 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF00412//PF07562 LIM domain//Nine Cysteines Domain of family 3 GPCR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0008270 G-protein coupled receptor activity//zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.36353 BP_3 2050.26 15.46 6683 642922676 XP_008193275.1 5069 0.0e+00 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X7 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 1706 2.7e-188 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF13895//PF02443//PF01086//PF00815//PF00057//PF10584 Immunoglobulin domain//Circovirus capsid protein//Clathrin light chain//Histidinol dehydrogenase//Low-density lipoprotein receptor domain class A//Proteasome subunit A N-terminal signature GO:0019069//GO:0000105//GO:0006511//GO:0055114//GO:0006886//GO:0016192 viral capsid assembly//histidine biosynthetic process//ubiquitin-dependent protein catabolic process//oxidation-reduction process//intracellular protein transport//vesicle-mediated transport GO:0004175//GO:0005515//GO:0051287//GO:0008270//GO:0004399//GO:0005198 endopeptidase activity//protein binding//NAD binding//zinc ion binding//histidinol dehydrogenase activity//structural molecule activity GO:0030130//GO:0019773//GO:0030132//GO:0042025 clathrin coat of trans-Golgi network vesicle//proteasome core complex, alpha-subunit complex//clathrin coat of coated pit//host cell nucleus KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.36354 BP_3 421.75 11.76 2020 332375044 AEE62663.1 1970 4.8e-218 unknown [Dendroctonus ponderosae]>gi|478250038|gb|ENN70544.1| hypothetical protein YQE_12719, partial [Dendroctonus ponderosae]>gi|546672620|gb|ERL84416.1| hypothetical protein D910_01849 [Dendroctonus ponderosae] 332375043 BT127701.1 341 2.50101e-176 Dendroctonus ponderosae clone DPO096_E18 unknown mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 P34455 1632 3.1e-180 Probable aconitate hydratase, mitochondrial OS=Caenorhabditis elegans GN=aco-2 PE=3 SV=2 PF00330 Aconitase family (aconitate hydratase) GO:0008152 metabolic process -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.36355 BP_3 8917.09 209.83 2340 332373768 AEE62025.1 1732 2.2e-190 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W303 1137 9.0e-123 Chitinase-like protein Idgf4 OS=Drosophila melanogaster GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.36356 BP_3 834.69 18.39 2479 270005044 EFA01492.1 3824 0.0e+00 hypothetical protein TcasGA2_TC007046 [Tribolium castaneum] 817215189 XM_012428330.1 84 2.25928e-33 PREDICTED: Orussus abietinus E3 ubiquitin-protein ligase HECTD1 (LOC105701521), transcript variant X4, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 2740 1.3e-308 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF06701 Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0046872 ubiquitin-protein transferase activity//metal ion binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.36357 BP_3 522.87 12.09 2376 478258440 ENN78530.1 451 7.8e-42 hypothetical protein YQE_05004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q55BM1 131 4.1e-06 Probable inactive protein kinase DDB_G0270444 OS=Dictyostelium discoideum GN=DDB_G0270444 PE=1 SV=1 PF02601//PF04210//PF05478 Exonuclease VII, large subunit//Tetrahydromethanopterin S-methyltransferase, subunit G//Prominin GO:0006308//GO:0046656//GO:0015948 DNA catabolic process//folic acid biosynthetic process//methanogenesis GO:0008855//GO:0030269 exodeoxyribonuclease VII activity//tetrahydromethanopterin S-methyltransferase activity GO:0009318//GO:0016021 exodeoxyribonuclease VII complex//integral component of membrane -- -- Cluster-8309.36361 BP_3 4651.85 370.44 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36362 BP_3 669.21 20.79 1843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36364 BP_3 413.00 2.12 9682 478252680 ENN73076.1 475 5.2e-44 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36365 BP_3 447.02 1.51 14583 642938921 XP_008195601.1 3295 0.0e+00 PREDICTED: PHD finger protein rhinoceros [Tribolium castaneum] 642938920 XM_008197379.1 365 0 PREDICTED: Tribolium castaneum PHD finger protein rhinoceros (LOC659824), mRNA -- -- -- -- Q7YZH1 1379 4.9e-150 PHD finger protein rhinoceros OS=Drosophila melanogaster GN=rno PE=1 SV=1 PF14560//PF00628//PF00130//PF00312//PF02214//PF03708//PF02136 Ubiquitin-like domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ribosomal protein S15//BTB/POZ domain//Avian retrovirus envelope protein, gp85//Nuclear transport factor 2 (NTF2) domain GO:0051260//GO:0006412//GO:0006810//GO:0035556//GO:0042254 protein homooligomerization//translation//transport//intracellular signal transduction//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0019031//GO:0005840//GO:0005622 viral envelope//ribosome//intracellular KOG3840 Uncharaterized conserved protein, contains BTB/POZ domain Cluster-8309.36366 BP_3 1553.17 99.38 1045 478263359 ENN81735.1 181 7.0e-11 hypothetical protein YQE_01874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36367 BP_3 420.00 8.73 2611 642937601 XP_008199116.1 2273 4.6e-253 PREDICTED: probable ATP-dependent RNA helicase CG8611 [Tribolium castaneum] -- -- -- -- -- K14806 DDX31, DBP7 ATP-dependent RNA helicase DDX31/DBP7 http://www.genome.jp/dbget-bin/www_bget?ko:K14806 Q86B47 1048 2.1e-112 Probable ATP-dependent RNA helicase CG8611 OS=Drosophila melanogaster GN=CG8611 PE=1 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0016787//GO:0003677//GO:0003676//GO:0005524 hydrolase activity//DNA binding//nucleic acid binding//ATP binding -- -- KOG0348 ATP-dependent RNA helicase Cluster-8309.36368 BP_3 1065.95 5.34 9919 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 436 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF01436//PF08165//PF00097//PF01601//PF03884//PF14634//PF00643//PF04566//PF13639//PF10588//PF04513//PF00651 NHL repeat//FerA (NUC095) domain//Zinc finger, C3HC4 type (RING finger)//Coronavirus S2 glycoprotein//Domain of unknown function (DUF329)//zinc-RING finger domain//B-box zinc finger//RNA polymerase Rpb2, domain 4//Ring finger domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Baculovirus polyhedron envelope protein, PEP, C terminus//BTB/POZ domain GO:0046813//GO:0006206//GO:0061025//GO:0006144//GO:0006351//GO:0055114 receptor-mediated virion attachment to host cell//pyrimidine nucleobase metabolic process//membrane fusion//purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process GO:0046872//GO:0005515//GO:0016491//GO:0003677//GO:0008270//GO:0005198//GO:0003899 metal ion binding//protein binding//oxidoreductase activity//DNA binding//zinc ion binding//structural molecule activity//DNA-directed RNA polymerase activity GO:0019031//GO:0005730//GO:0005622//GO:0016021//GO:0019028 viral envelope//nucleolus//intracellular//integral component of membrane//viral capsid KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.36369 BP_3 862.63 24.58 1983 270001906 EEZ98353.1 159 4.7e-08 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3637 BP_3 1.00 0.40 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36370 BP_3 355.56 9.18 2158 642937725 XP_008198919.1 550 2.3e-53 PREDICTED: tropomyosin-2 isoform X13 [Tribolium castaneum] 699049756 KM099072.1 334 2.0825e-172 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 480 1.3e-46 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF15898//PF04612//PF02601//PF08702//PF04799//PF02185//PF10473//PF05739//PF10186//PF10392//PF08651//PF05531//PF16326//PF06009 cGMP-dependent protein kinase interacting domain//Type II secretion system (T2SS), protein M//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//fzo-like conserved region//Hr1 repeat//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Vacuolar sorting 38 and autophagy-related subunit 14//Golgi transport complex subunit 5//DASH complex subunit Duo1//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//Laminin Domain II GO:0007165//GO:0051258//GO:0007067//GO:0006858//GO:0010508//GO:0006891//GO:0030168//GO:0007155//GO:0008053//GO:0006308 signal transduction//protein polymerization//mitotic nuclear division//extracellular transport//positive regulation of autophagy//intra-Golgi vesicle-mediated transport//platelet activation//cell adhesion//mitochondrial fusion//DNA catabolic process GO:0045502//GO:0003924//GO:0008134//GO:0019901//GO:0005102//GO:0003677//GO:0005515//GO:0008855//GO:0030674//GO:0042803 dynein binding//GTPase activity//transcription factor binding//protein kinase binding//receptor binding//DNA binding//protein binding//exodeoxyribonuclease VII activity//protein binding, bridging//protein homodimerization activity GO:0016021//GO:0019028//GO:0009318//GO:0042729//GO:0005577//GO:0030286//GO:0072686//GO:0005667//GO:0017119//GO:0005741 integral component of membrane//viral capsid//exodeoxyribonuclease VII complex//DASH complex//fibrinogen complex//dynein complex//mitotic spindle//transcription factor complex//Golgi transport complex//mitochondrial outer membrane KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.36371 BP_3 2061.00 26.03 4108 91092064 XP_970689.1 2035 2.8e-225 PREDICTED: selenium-binding protein 1 [Tribolium castaneum]>gi|270004695|gb|EFA01143.1| hypothetical protein TcasGA2_TC010368 [Tribolium castaneum] -- -- -- -- -- K17285 SELENBP1 selenium-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17285 Q52KZ7 1535 1.1e-168 Selenium-binding protein 1-A OS=Xenopus laevis GN=selenbp1-a PE=2 SV=1 PF00474//PF06432//PF05694 Sodium:solute symporter family//Phosphatidylinositol N-acetylglucosaminyltransferase//56kDa selenium binding protein (SBP56) GO:0006506//GO:0006810//GO:0055085 GPI anchor biosynthetic process//transport//transmembrane transport GO:0008430//GO:0005215//GO:0017176 selenium binding//transporter activity//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0918 Selenium-binding protein Cluster-8309.36373 BP_3 238.57 0.96 12241 91092056 XP_970271.1 4135 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] 157125487 XM_001654304.1 70 6.83368e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 3356 0.0e+00 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF01884//PF06574//PF01207//PF01593//PF07992//PF01704//PF04218//PF00070//PF00196//PF01180//PF05946//PF02796//PF05225//PF03184//PF04545 PcrB family//FAD synthetase//Dihydrouridine synthase (Dus)//Flavin containing amine oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//UTP--glucose-1-phosphate uridylyltransferase//CENP-B N-terminal DNA-binding domain//Pyridine nucleotide-disulphide oxidoreductase//Bacterial regulatory proteins, luxR family//Dihydroorotate dehydrogenase//Toxin-coregulated pilus subunit TcpA//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//DDE superfamily endonuclease//Sigma-70, region 4 GO:0006310//GO:0006771//GO:0009231//GO:0008152//GO:0055114//GO:0006118//GO:0006352//GO:0006206//GO:0006222//GO:0008033//GO:0006355//GO:0009405//GO:0006207 DNA recombination//riboflavin metabolic process//riboflavin biosynthetic process//metabolic process//oxidation-reduction process//obsolete electron transport//DNA-templated transcription, initiation//pyrimidine nucleobase metabolic process//UMP biosynthetic process//tRNA processing//regulation of transcription, DNA-templated//pathogenesis//'de novo' pyrimidine nucleobase biosynthetic process GO:0016987//GO:0003676//GO:0016491//GO:0003700//GO:0016765//GO:0070569//GO:0009055//GO:0050660//GO:0017150//GO:0004158//GO:0003677//GO:0016627//GO:0003919//GO:0051536//GO:0000150 sigma factor activity//nucleic acid binding//oxidoreductase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring alkyl or aryl (other than methyl) groups//uridylyltransferase activity//electron carrier activity//flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity//dihydroorotate oxidase activity//DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//FMN adenylyltransferase activity//iron-sulfur cluster binding//recombinase activity GO:0005667//GO:0043230//GO:0005737//GO:0009289 transcription factor complex//extracellular organelle//cytoplasm//pilus KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.36374 BP_3 21.51 0.59 2063 189239891 XP_969420.2 460 6.1e-43 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Tribolium castaneum] -- -- -- -- -- K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 330 3.0e-29 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF02148//PF04434 Zn-finger in ubiquitin-hydrolases and other protein//SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- KOG1139 Predicted ubiquitin-protein ligase of the N-recognin family Cluster-8309.36375 BP_3 542.65 2.03 13163 642920090 XP_008192200.1 2081 4.2e-230 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920089 XM_008193978.1 379 0 PREDICTED: Tribolium castaneum histone acetyltransferase Tip60 (LOC664310), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q5RBG4 1549 8.5e-170 Histone acetyltransferase KAT5 OS=Pongo abelii GN=KAT5 PE=2 SV=1 PF03719//PF13855//PF01853//PF00560//PF13508//PF00583//PF05261//PF00333 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//MOZ/SAS family//Leucine Rich Repeat//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//TraM protein, DNA-binding//Ribosomal protein S5, N-terminal domain GO:0042967//GO:0006412//GO:0042254//GO:0000746//GO:0006355 acyl-carrier-protein biosynthetic process//translation//ribosome biogenesis//conjugation//regulation of transcription, DNA-templated GO:0005515//GO:0008080//GO:0003677//GO:0003723//GO:0016747//GO:0003735 protein binding//N-acetyltransferase activity//DNA binding//RNA binding//transferase activity, transferring acyl groups other than amino-acyl groups//structural constituent of ribosome GO:0005634//GO:0005840 nucleus//ribosome KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.36377 BP_3 270.91 11.03 1476 329762922 AEC04842.1 617 2.7e-61 chemosensory protein [Batocera horsfieldi] 329762921 HQ587040.1 393 0 Batocera horsfieldi chemosensory protein (CSP1) mRNA, complete cds -- -- -- -- Q9W1C9 283 6.0e-24 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36379 BP_3 8.23 0.46 1153 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36380 BP_3 4756.71 17.42 13452 642911254 XP_008199787.1 11406 0.0e+00 PREDICTED: filamin-A isoform X1 [Tribolium castaneum] 642911253 XM_008201565.1 2003 0 PREDICTED: Tribolium castaneum filamin-A (LOC661488), transcript variant X1, mRNA K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q9VEN1 5214 0.0e+00 Filamin-A OS=Drosophila melanogaster GN=cher PE=1 SV=2 PF01105//PF07859//PF00688//PF00307 emp24/gp25L/p24 family/GOLD//alpha/beta hydrolase fold//TGF-beta propeptide//Calponin homology (CH) domain GO:0008283//GO:0006810//GO:0040007//GO:0008152//GO:0007165 cell proliferation//transport//growth//metabolic process//signal transduction GO:0005515//GO:0008083//GO:0016787 protein binding//growth factor activity//hydrolase activity GO:0016021 integral component of membrane KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.36381 BP_3 11374.31 190.41 3171 642926068 XP_008194752.1 4230 0.0e+00 PREDICTED: calsyntenin-1 [Tribolium castaneum] 759049730 XM_011335629.1 160 1.63607e-75 PREDICTED: Cerapachys biroi calsyntenin-1 (LOC105277343), transcript variant X2, mRNA -- -- -- -- Q9V498 1781 2.6e-197 Calsyntenin-1 OS=Drosophila melanogaster GN=Cals PE=1 SV=2 PF07953//PF00722//PF00028 Clostridium neurotoxin, N-terminal receptor binding//Glycosyl hydrolases family 16//Cadherin domain GO:0007165//GO:0009405//GO:0007156//GO:0051609//GO:0005975 signal transduction//pathogenesis//homophilic cell adhesion via plasma membrane adhesion molecules//inhibition of neurotransmitter uptake//carbohydrate metabolic process GO:0004553//GO:0004222//GO:0005509//GO:0050827 hydrolase activity, hydrolyzing O-glycosyl compounds//metalloendopeptidase activity//calcium ion binding//toxin receptor binding GO:0016020//GO:0005576 membrane//extracellular region KOG1834 Calsyntenin Cluster-8309.36382 BP_3 3633.47 24.70 7381 507228 AAA64736.1 693 2.1e-69 apolipophorin-III, partial [Derobrachus geminatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00430//PF05866//PF06667//PF04108//PF05823//PF00804//PF07464//PF03623//PF10280//PF05478//PF06008//PF01442//PF05531//PF02993//PF06109//PF10150//PF01474//PF06320//PF14942//PF04799//PF04513//PF02601 ATP synthase B/B' CF(0)//Endodeoxyribonuclease RusA//Phage shock protein B//Autophagy protein Apg17//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Syntaxin//Apolipophorin-III precursor (apoLp-III)//Focal adhesion targeting region//Mediator complex protein//Prominin//Laminin Domain I//Apolipoprotein A1/A4/E domain//Nucleopolyhedrovirus P10 protein//Minor capsid protein VI//Haemolysin E (HlyE)//Ribonuclease E/G family//Class-II DAHP synthetase family//GCN5-like protein 1 (GCN5L1)//Organelle biogenesis, Muted-like protein//fzo-like conserved region//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit GO:0008053//GO:0006310//GO:0000162//GO:0009073//GO:0007172//GO:0006357//GO:0045995//GO:0015992//GO:0006571//GO:0015986//GO:0030155//GO:0009094//GO:0006308//GO:0042157//GO:0006869//GO:0006355//GO:0009271//GO:0044179//GO:0030334//GO:0007165//GO:0009405//GO:0006281//GO:0006914//GO:0006468 mitochondrial fusion//DNA recombination//tryptophan biosynthetic process//aromatic amino acid family biosynthetic process//signal complex assembly//regulation of transcription from RNA polymerase II promoter//regulation of embryonic development//proton transport//tyrosine biosynthetic process//ATP synthesis coupled proton transport//regulation of cell adhesion//L-phenylalanine biosynthetic process//DNA catabolic process//lipoprotein metabolic process//lipid transport//regulation of transcription, DNA-templated//phage shock//hemolysis in other organism//regulation of cell migration//signal transduction//pathogenesis//DNA repair//autophagy//protein phosphorylation GO:0001104//GO:0008289//GO:0005102//GO:0003924//GO:0004871//GO:0000287//GO:0004713//GO:0003723//GO:0008855//GO:0015078//GO:0003849//GO:0005198 RNA polymerase II transcription cofactor activity//lipid binding//receptor binding//GTPase activity//signal transducer activity//magnesium ion binding//protein tyrosine kinase activity//RNA binding//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//3-deoxy-7-phosphoheptulonate synthase activity//structural molecule activity GO:0031083//GO:0016592//GO:0009318//GO:0005925//GO:0019028//GO:0016020//GO:0005576//GO:0005741//GO:0030133//GO:0019031//GO:0045263//GO:0016021 BLOC-1 complex//mediator complex//exodeoxyribonuclease VII complex//focal adhesion//viral capsid//membrane//extracellular region//mitochondrial outer membrane//transport vesicle//viral envelope//proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.36383 BP_3 75.00 4.09 1175 270007633 EFA04081.1 228 2.8e-16 hypothetical protein TcasGA2_TC014315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36385 BP_3 8832.00 309.76 1666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14631//PF01080//PF04931//PF03286//PF06327//PF00527//PF15351 Fanconi anaemia protein FancD2 nuclease//Presenilin//DNA polymerase phi//Pox virus Ag35 surface protein//Domain of Unknown Function (DUF1053)//E7 protein, Early protein//Junctional protein associated with coronary artery disease GO:0006260//GO:0006355//GO:0006281//GO:0006351//GO:0006171//GO:0006144 DNA replication//regulation of transcription, DNA-templated//DNA repair//transcription, DNA-templated//cAMP biosynthetic process//purine nucleobase metabolic process GO:0003700//GO:0004016//GO:0004190//GO:0003677//GO:0003887 transcription factor activity, sequence-specific DNA binding//adenylate cyclase activity//aspartic-type endopeptidase activity//DNA binding//DNA-directed DNA polymerase activity GO:0005911//GO:0016021//GO:0042575//GO:0005886//GO:0019031//GO:0005667 cell-cell junction//integral component of membrane//DNA polymerase complex//plasma membrane//viral envelope//transcription factor complex -- -- Cluster-8309.36386 BP_3 1289.00 91.33 972 91077774 XP_968953.1 1181 7.2e-127 PREDICTED: ribosome biogenesis protein NSA2 homolog [Tribolium castaneum]>gi|270002241|gb|EEZ98688.1| hypothetical protein TcasGA2_TC001224 [Tribolium castaneum] 758274572 KP073488.1 271 9.6712e-138 Heliconius hermathena voucher 94_15 hairy cell leukemia protein (Hcl) gene, partial cds K14842 NSA2 ribosome biogenesis protein NSA2 http://www.genome.jp/dbget-bin/www_bget?ko:K14842 Q3SX11 1009 2.6e-108 Ribosome biogenesis protein NSA2 homolog OS=Bos taurus GN=NSA2 PE=2 SV=1 PF09036 Bcr-Abl oncoprotein oligomerisation domain GO:0007165//GO:0016310//GO:0009069//GO:0006468 signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005096//GO:0004674 GTPase activator activity//protein serine/threonine kinase activity -- -- KOG3163 Uncharacterized conserved protein related to ribosomal protein S8E Cluster-8309.36387 BP_3 1268.55 53.02 1445 91082025 XP_970311.1 727 4.7e-74 PREDICTED: vacuolar protein sorting-associated protein VTA1 homolog [Tribolium castaneum]>gi|270007383|gb|EFA03831.1| hypothetical protein TcasGA2_TC013947 [Tribolium castaneum] -- -- -- -- -- K12199 VTA1, LIP5 vacuolar protein sorting-associated protein VTA1 http://www.genome.jp/dbget-bin/www_bget?ko:K12199 Q32L63 544 3.2e-54 Vacuolar protein sorting-associated protein VTA1 homolog OS=Bos taurus GN=VTA1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0917 Uncharacterized conserved protein Cluster-8309.36389 BP_3 1237.28 8.39 7402 642939440 XP_008200392.1 4003 0.0e+00 PREDICTED: maternal protein pumilio isoform X5 [Tribolium castaneum] 642939439 XM_008202170.1 661 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X5, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF00806//PF02422//PF08144 Pumilio-family RNA binding repeat//Keratin//CPL (NUC119) domain -- -- GO:0005200//GO:0003723 structural constituent of cytoskeleton//RNA binding GO:0005882//GO:0005856 intermediate filament//cytoskeleton KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.36390 BP_3 276.88 2.65 5319 91082899 XP_972170.1 2591 1.2e-289 PREDICTED: protein spire [Tribolium castaneum]>gi|270008222|gb|EFA04670.1| spire [Tribolium castaneum] 770075505 NM_001305498.1 122 3.66884e-54 Plutella xylostella translationally-controlled tumor protein homolog (LOC105389397), mRNA >gnl|BL_ORD_ID|1274647 Plutella xylostella mRNA for translationally controlled tumor protein, complete cds K02098 SPIR spire http://www.genome.jp/dbget-bin/www_bget?ko:K02098 Q75VN3 776 1.5e-80 Translationally-controlled tumor protein homolog OS=Bombyx mori GN=Tctp PE=2 SV=1 PF02205//PF00130 WH2 motif//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0003779 actin binding -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.36391 BP_3 96.00 81.76 342 91077564 XP_972465.1 296 1.1e-24 PREDICTED: muscle-specific protein 20 isoform X2 [Tribolium castaneum]>gi|270002170|gb|EEZ98617.1| hypothetical protein TcasGA2_TC001139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14318 176 3.6e-12 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain GO:0031032 actomyosin structure organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG2046 Calponin Cluster-8309.36392 BP_3 14571.97 378.37 2148 50982101 AAT91723.1 445 3.5e-41 LIM protein [Apriona germari] 50982100 AY703482.1 453 0 Apriona germari muscle LIM protein mRNA, complete cds K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 P53777 359 1.4e-32 Muscle LIM protein 1 OS=Drosophila melanogaster GN=Mlp60A PE=2 SV=1 PF00412//PF00643//PF00096//PF03119 LIM domain//B-box zinc finger//Zinc finger, C2H2 type//NAD-dependent DNA ligase C4 zinc finger domain GO:0006260//GO:0006281 DNA replication//DNA repair GO:0003911//GO:0008270//GO:0046872 DNA ligase (NAD+) activity//zinc ion binding//metal ion binding GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36393 BP_3 7.44 0.46 1068 50982101 AAT91723.1 433 4.3e-40 LIM protein [Apriona germari] 50982100 AY703482.1 236 3.04923e-118 Apriona germari muscle LIM protein mRNA, complete cds K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 P53777 359 6.7e-33 Muscle LIM protein 1 OS=Drosophila melanogaster GN=Mlp60A PE=2 SV=1 PF00643//PF00412//PF03119//PF00096 B-box zinc finger//LIM domain//NAD-dependent DNA ligase C4 zinc finger domain//Zinc finger, C2H2 type GO:0006281//GO:0006260 DNA repair//DNA replication GO:0046872//GO:0008270//GO:0003911 metal ion binding//zinc ion binding//DNA ligase (NAD+) activity GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36394 BP_3 2437.21 12.43 9742 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 553 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 1.9e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF00651//PF04513//PF13639//PF04566//PF10588//PF14634//PF00643//PF01601//PF03884//PF00097//PF08165//PF01436 BTB/POZ domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Ring finger domain//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//zinc-RING finger domain//B-box zinc finger//Coronavirus S2 glycoprotein//Domain of unknown function (DUF329)//Zinc finger, C3HC4 type (RING finger)//FerA (NUC095) domain//NHL repeat GO:0006206//GO:0061025//GO:0046813//GO:0006351//GO:0006144//GO:0055114 pyrimidine nucleobase metabolic process//membrane fusion//receptor-mediated virion attachment to host cell//transcription, DNA-templated//purine nucleobase metabolic process//oxidation-reduction process GO:0046872//GO:0003677//GO:0005515//GO:0016491//GO:0008270//GO:0003899//GO:0005198 metal ion binding//DNA binding//protein binding//oxidoreductase activity//zinc ion binding//DNA-directed RNA polymerase activity//structural molecule activity GO:0019031//GO:0005622//GO:0005730//GO:0016021//GO:0019028 viral envelope//intracellular//nucleolus//integral component of membrane//viral capsid KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.36395 BP_3 14066.00 64.97 10727 642918534 XP_008191512.1 790 1.7e-80 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 425 1.5e-39 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36396 BP_3 30.45 1.01 1744 91077322 XP_974743.1 892 4.2e-93 PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|642913792|ref|XP_008201162.1| PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|270002090|gb|EEZ98537.1| hypothetical protein TcasGA2_TC001041 [Tribolium castaneum] 632985180 XM_007911344.1 101 5.60225e-43 PREDICTED: Callorhinchus milii pre-mRNA processing factor 18 (prpf18), mRNA K12817 PRPF18, PRP18 pre-mRNA-splicing factor 18 http://www.genome.jp/dbget-bin/www_bget?ko:K12817 Q8BM39 497 1.1e-48 Pre-mRNA-splicing factor 18 OS=Mus musculus GN=Prpf18 PE=2 SV=1 PF02840 Prp18 domain GO:0008380 RNA splicing -- -- GO:0005681 spliceosomal complex KOG2808 U5 snRNP-associated RNA splicing factor Cluster-8309.36397 BP_3 703.86 6.37 5615 270005127 EFA01575.1 1872 3.1e-206 hypothetical protein TcasGA2_TC007136 [Tribolium castaneum] 674656866 KJ872589.1 597 0 Monochamus alternatus muscle LIM protein mRNA, partial cds -- -- -- -- Q24400 1544 1.4e-169 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412//PF00643//PF03119//PF00096 LIM domain//B-box zinc finger//NAD-dependent DNA ligase C4 zinc finger domain//Zinc finger, C2H2 type GO:0006281//GO:0006260 DNA repair//DNA replication GO:0046872//GO:0003911//GO:0008270 metal ion binding//DNA ligase (NAD+) activity//zinc ion binding GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36398 BP_3 1852.12 13.05 7133 478257467 ENN77623.1 2412 9.5e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 795110653 XM_012026968.1 123 1.36971e-54 PREDICTED: Vollenhovia emeryi alpha-protein kinase 1 (LOC105570040), transcript variant X5, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 3.3e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF00097//PF00408//PF14634//PF15965//PF02880//PF00076//PF13639//PF02879//PF02878 Zinc finger, C3HC4 type (RING finger)//Phosphoglucomutase/phosphomannomutase, C-terminal domain//zinc-RING finger domain//TRAF-like zinc-finger//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ring finger domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0005975//GO:0071704 carbohydrate metabolic process//organic substance metabolic process GO:0005515//GO:0046872//GO:0016868//GO:0003676//GO:0008270 protein binding//metal ion binding//intramolecular transferase activity, phosphotransferases//nucleic acid binding//zinc ion binding -- -- KOG0625 Phosphoglucomutase Cluster-8309.36400 BP_3 4050.67 134.53 1743 332376523 AEE63401.1 2173 1.2e-241 unknown [Dendroctonus ponderosae]>gi|478249799|gb|ENN70306.1| hypothetical protein YQE_12817, partial [Dendroctonus ponderosae]>gi|546682880|gb|ERL92766.1| hypothetical protein D910_10075 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38942 975 4.1e-104 4-hydroxybutyrate coenzyme A transferase OS=Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) GN=cat2 PE=3 SV=3 PF02550 Acetyl-CoA hydrolase/transferase N-terminal domain GO:0006084 acetyl-CoA metabolic process GO:0003824 catalytic activity -- -- KOG2828 Acetyl-CoA hydrolase Cluster-8309.36401 BP_3 328.00 11.82 1629 332375552 AEE62917.1 807 2.8e-83 unknown [Dendroctonus ponderosae]>gi|478250658|gb|ENN71150.1| hypothetical protein YQE_12081, partial [Dendroctonus ponderosae]>gi|546677242|gb|ERL88111.1| hypothetical protein D910_05500 [Dendroctonus ponderosae] 170069759 XM_001869304.1 164 4.97281e-78 Culex quinquefasciatus NADH dehydrogenase iron-sulfur protein 7, mitochondrial, mRNA K03940 NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03940 P0CB83 655 4.9e-67 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Pongo abelii GN=NDUFS7 PE=2 SV=1 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit GO:0055114 oxidation-reduction process GO:0051536 iron-sulfur cluster binding -- -- KOG1687 NADH-ubiquinone oxidoreductase, NUFS7/PSST/20 kDa subunit Cluster-8309.36402 BP_3 4156.00 505.48 688 67527227 AAY68367.1 880 4.1e-92 muscle protein 20-like protein [Anoplophora glabripennis] 67527226 DQ067276.1 342 2.29178e-177 Anoplophora glabripennis muscle protein 20-like protein mRNA, complete cds -- -- -- -- P14318 714 3.0e-74 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.36403 BP_3 1199.42 28.34 2332 270009742 EFA06190.1 2085 2.6e-231 hypothetical protein TcasGA2_TC009039 [Tribolium castaneum] -- -- -- -- -- K17043 DDX43 ATP-dependent RNA helicase DDX43 http://www.genome.jp/dbget-bin/www_bget?ko:K17043 Q9NXZ2 1382 3.5e-151 Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens GN=DDX43 PE=2 SV=2 PF00176//PF00013//PF04851//PF13014//PF00270//PF07650 SNF2 family N-terminal domain//KH domain//Type III restriction enzyme, res subunit//KH domain//DEAD/DEAH box helicase//KH domain -- -- GO:0003723//GO:0005524//GO:0003677//GO:0016787//GO:0003676 RNA binding//ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.36404 BP_3 38.73 0.89 2390 642920110 XP_008192209.1 1184 7.9e-127 PREDICTED: putative oxidoreductase GLYR1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q161 831 2.8e-87 Putative oxidoreductase GLYR1 homolog OS=Anopheles gambiae GN=AGAP009949 PE=3 SV=5 PF14833//PF03446//PF16519 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//NAD binding domain of 6-phosphogluconate dehydrogenase//Tetramerisation domain of TRPM GO:0019521//GO:0006098//GO:0051262//GO:0055114 D-gluconate metabolic process//pentose-phosphate shunt//protein tetramerization//oxidation-reduction process GO:0004616//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding -- -- KOG0409 Predicted dehydrogenase Cluster-8309.36405 BP_3 29377.03 534.27 2942 91079989 XP_970719.1 3290 0.0e+00 PREDICTED: paramyosin, long form [Tribolium castaneum] 332374739 BT127549.1 1051 0 Dendroctonus ponderosae clone DPO0813_C03 unknown mRNA -- -- -- -- P35415 2724 1.1e-306 Paramyosin, long form OS=Drosophila melanogaster GN=Prm PE=1 SV=1 PF00038//PF01576//PF05221//PF00015 Intermediate filament protein//Myosin tail//S-adenosyl-L-homocysteine hydrolase//Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165//GO:0006555//GO:0006730 signal transduction//methionine metabolic process//one-carbon metabolic process GO:0005198//GO:0004013//GO:0003774//GO:0004871 structural molecule activity//adenosylhomocysteinase activity//motor activity//signal transducer activity GO:0005882//GO:0016459//GO:0016020 intermediate filament//myosin complex//membrane KOG0161 Myosin class II heavy chain Cluster-8309.36406 BP_3 53.41 1.00 2862 642922794 XP_008193328.1 2003 1.0e-221 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 5.1e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF08496//PF06905//PF11965//PF03357 Peptidase family S49 N-terminal//Fas apoptotic inhibitory molecule (FAIM1)//Domain of unknown function (DUF3479)//Snf7 GO:0007034//GO:0015994//GO:0043066 vacuolar transport//chlorophyll metabolic process//negative regulation of apoptotic process GO:0016851//GO:0004252 magnesium chelatase activity//serine-type endopeptidase activity GO:0005886//GO:0010007 plasma membrane//magnesium chelatase complex -- -- Cluster-8309.36407 BP_3 198.77 2.21 4619 478261315 ENN80731.1 2577 4.5e-288 hypothetical protein YQE_02839, partial [Dendroctonus ponderosae] 391330831 XM_003739808.1 45 2.02704e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 461 4.3e-44 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF01844//PF00122//PF07961 HNH endonuclease//E1-E2 ATPase//MBA1-like protein GO:0032979 protein insertion into mitochondrial membrane from inner side GO:0046872//GO:0000166//GO:0004519//GO:0003676 metal ion binding//nucleotide binding//endonuclease activity//nucleic acid binding GO:0005743 mitochondrial inner membrane KOG4383 Uncharacterized conserved protein Cluster-8309.36408 BP_3 12648.13 121.07 5327 642939071 XP_008200210.1 2291 7.6e-255 PREDICTED: DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [Tribolium castaneum] 158300605 XM_320481.4 215 7.35819e-106 Anopheles gambiae str. PEST AGAP012045-PA (AgaP_AGAP012045) mRNA, complete cds K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1374 6.7e-150 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF04851//PF01019//PF00816//PF00270 Type III restriction enzyme, res subunit//Gamma-glutamyltranspeptidase//H-NS histone family//DEAD/DEAH box helicase GO:0006691//GO:0006355//GO:0006693//GO:0019530//GO:0006749 leukotriene metabolic process//regulation of transcription, DNA-templated//prostaglandin metabolic process//taurine metabolic process//glutathione metabolic process GO:0003840//GO:0003676//GO:0005524//GO:0016787//GO:0003677 gamma-glutamyltransferase activity//nucleic acid binding//ATP binding//hydrolase activity//DNA binding GO:0005622 intracellular KOG0331 ATP-dependent RNA helicase Cluster-8309.36410 BP_3 44.88 6.65 617 332373768 AEE62025.1 482 5.1e-46 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q23997 353 1.9e-32 Chitinase-like protein CG5210 OS=Drosophila melanogaster GN=CG5210 PE=1 SV=2 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.36411 BP_3 1022.00 10.14 5150 478257412 ENN77568.1 1668 1.3e-182 hypothetical protein YQE_05864, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9I7U4 1162 2.5e-125 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36412 BP_3 2967.00 107.83 1618 478253720 ENN74019.1 1457 1.2e-158 hypothetical protein YQE_09409, partial [Dendroctonus ponderosae]>gi|546685011|gb|ERL94576.1| hypothetical protein D910_11853 [Dendroctonus ponderosae] 528520776 XM_005170654.1 161 2.29766e-76 PREDICTED: Danio rerio solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b (slc25a3b), transcript variant X1, mRNA K15102 SLC25A3, PHC, PIC solute carrier family 25 (mitochondrial phosphate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15102 P16036 1168 1.6e-126 Phosphate carrier protein, mitochondrial OS=Rattus norvegicus GN=Slc25a3 PE=1 SV=1 PF02405 Permease MlaE GO:0006810 transport -- -- GO:0043190 ATP-binding cassette (ABC) transporter complex KOG0767 Mitochondrial phosphate carrier protein Cluster-8309.36413 BP_3 10427.66 31.36 16318 642918534 XP_008191512.1 19534 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 3224 0 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 15939 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF14980//PF02502//PF05790//PF13895//PF02480 TIP39 peptide//Ribose/Galactose Isomerase//Immunoglobulin C2-set domain//Immunoglobulin domain//Alphaherpesvirus glycoprotein E GO:0007218//GO:0007155//GO:0005975 neuropeptide signaling pathway//cell adhesion//carbohydrate metabolic process GO:0005515//GO:0016853 protein binding//isomerase activity GO:0016021//GO:0016020//GO:0005576 integral component of membrane//membrane//extracellular region -- -- Cluster-8309.36414 BP_3 11230.41 373.50 1741 270014971 EFA11419.1 1641 5.9e-180 hypothetical protein TcasGA2_TC013596 [Tribolium castaneum] 290048170 GU396008.1 405 0 Helicoverpa armigera arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 P48610 1581 2.2e-174 Arginine kinase OS=Drosophila melanogaster GN=Argk PE=2 SV=2 PF00217//PF02807 ATP:guanido phosphotransferase, C-terminal catalytic domain//ATP:guanido phosphotransferase, N-terminal domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.36415 BP_3 1274.87 32.94 2157 332374576 AEE62429.1 1472 2.9e-160 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 295 9.96231e-151 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1258 7.7e-137 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- -- -- Cluster-8309.36416 BP_3 831.70 11.47 3786 642940096 XP_008192965.1 1556 9.2e-170 PREDICTED: paxillin isoform X6 [Tribolium castaneum]>gi|270016014|gb|EFA12462.1| hypothetical protein TcasGA2_TC010609 [Tribolium castaneum] 665811408 XM_008555945.1 200 1.13689e-97 PREDICTED: Microplitis demolitor leupaxin-like (LOC103575940), mRNA K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 P49024 851 2.1e-89 Paxillin OS=Gallus gallus GN=PXN PE=1 SV=1 PF04216//PF03498//PF05923//PF00412 Protein involved in formate dehydrogenase formation//Cytolethal distending toxin A/C domain//APC cysteine-rich region//LIM domain GO:0016055//GO:0009405 Wnt signaling pathway//pathogenesis GO:0043169//GO:0008270 cation binding//zinc ion binding GO:0005737 cytoplasm KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.36418 BP_3 603.36 5.73 5371 808128173 XP_012166984.1 2964 0.0e+00 PREDICTED: myosin heavy chain, muscle isoform X5 [Bombus terrestris] 642931316 XM_008198307.1 960 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2700 1.2e-303 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF08001//PF00063//PF02736//PF05060 CMV US//Myosin head (motor domain)//Myosin N-terminal SH3-like domain//N-acetylglucosaminyltransferase II (MGAT2) GO:0009312//GO:0030683 oligosaccharide biosynthetic process//evasion or tolerance by virus of host immune response GO:0005524//GO:0008455//GO:0003774 ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity//motor activity GO:0016021//GO:0016459//GO:0005795//GO:0044386 integral component of membrane//myosin complex//Golgi stack//integral to host endoplasmic reticulum membrane KOG0161 Myosin class II heavy chain Cluster-8309.36420 BP_3 3047.00 257.99 861 -- -- -- -- -- 359294281 JN986793.1 720 0 Batocera lineolata mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36421 BP_3 142.00 1032.44 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01972//PF06624//PF10280 Serine dehydrogenase proteinase//Ribosome associated membrane protein RAMP4//Mediator complex protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0005783//GO:0016592//GO:0016021 endoplasmic reticulum//mediator complex//integral component of membrane -- -- Cluster-8309.36422 BP_3 298.73 13.37 1369 642930671 XP_008199218.1 636 1.6e-63 PREDICTED: uncharacterized protein LOC100142507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36423 BP_3 8614.89 111.16 4027 820857060 XP_012345672.1 1954 6.9e-216 PREDICTED: actin, clone 205-like isoform X1 [Apis florea] 55783599 AY817141.1 1112 0 Apriona germari actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P41339 1911 2.7e-212 Actin, acrosomal process isoform OS=Limulus polyphemus PE=2 SV=1 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- KOG0676 Actin and related proteins Cluster-8309.36425 BP_3 1913.00 157.54 877 557876145 AHA39267.1 585 8.3e-58 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.36426 BP_3 966.64 12.05 4157 546673641 ERL85205.1 1561 2.7e-170 hypothetical protein D910_02626 [Dendroctonus ponderosae] -- -- -- -- -- K17307 FBLN1_2 fibulin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17307 O77469 617 3.2e-62 Fibulin-1 OS=Caenorhabditis elegans GN=fbl-1 PE=1 SV=3 PF04947//PF00008//PF07645//PF04814//PF00906//PF06247 Poxvirus Late Transcription Factor VLTF3 like//EGF-like domain//Calcium-binding EGF domain//Hepatocyte nuclear factor 1 (HNF-1), N terminus//Hepatitis core antigen//Plasmodium ookinete surface protein Pvs28 GO:0009405//GO:0046782//GO:0045893 pathogenesis//regulation of viral transcription//positive regulation of transcription, DNA-templated GO:0005198//GO:0005515//GO:0005509 structural molecule activity//protein binding//calcium ion binding GO:0005634//GO:0009986//GO:0016020 nucleus//cell surface//membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.36427 BP_3 24709.78 370.76 3504 820857060 XP_012345672.1 1954 6.0e-216 PREDICTED: actin, clone 205-like isoform X1 [Apis florea] 55783599 AY817141.1 1112 0 Apriona germari actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P41339 1911 2.4e-212 Actin, acrosomal process isoform OS=Limulus polyphemus PE=2 SV=1 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- KOG0676 Actin and related proteins Cluster-8309.36428 BP_3 720.94 5.56 6536 642915533 XP_008190655.1 1572 2.2e-171 PREDICTED: tyrosine-protein phosphatase non-receptor type 61F isoform X1 [Tribolium castaneum] -- -- -- -- -- K18026 PTPN2, PTPT tyrosine-protein phosphatase non-receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18026 Q9W0G1 859 4.3e-90 Tyrosine-protein phosphatase non-receptor type 61F OS=Drosophila melanogaster GN=Ptp61F PE=1 SV=1 PF03119//PF00102//PF01396//PF00782//PF03248//PF08043 NAD-dependent DNA ligase C4 zinc finger domain//Protein-tyrosine phosphatase//Topoisomerase DNA binding C4 zinc finger//Dual specificity phosphatase, catalytic domain//Rer1 family//Xin repeat GO:0006570//GO:0006470//GO:0006281//GO:0030036//GO:0006265//GO:0006260 tyrosine metabolic process//protein dephosphorylation//DNA repair//actin cytoskeleton organization//DNA topological change//DNA replication GO:0003779//GO:0008138//GO:0004725//GO:0003916//GO:0003677//GO:0003911 actin binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//DNA topoisomerase activity//DNA binding//DNA ligase (NAD+) activity GO:0016021//GO:0005694//GO:0030054 integral component of membrane//chromosome//cell junction -- -- Cluster-8309.36429 BP_3 19.20 0.34 3033 91079134 XP_975446.1 877 4.0e-91 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|642916464|ref|XP_008191038.1| PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270004224|gb|EFA00672.1| hypothetical protein TcasGA2_TC003549 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 P80034 579 5.9e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- GO:0006561//GO:0055114//GO:0055129//GO:0006525 proline biosynthetic process//oxidation-reduction process//L-proline biosynthetic process//arginine metabolic process GO:0000166//GO:0004735 nucleotide binding//pyrroline-5-carboxylate reductase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.36430 BP_3 58.68 1.31 2455 546678378 ERL89011.1 592 3.6e-58 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 497 1.5e-48 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 PF04911 ATP synthase j chain GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) KOG3936 Nitroreductases Cluster-8309.36432 BP_3 5270.88 22.02 11830 642918413 XP_008191462.1 2554 5.4e-285 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|642918415|ref|XP_008191463.1| PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|270003254|gb|EEZ99701.1| hypothetical protein TcasGA2_TC002462 [Tribolium castaneum] 642931619 XM_966443.2 176 7.84696e-84 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 P50416 1642 1.3e-180 Carnitine O-palmitoyltransferase 1, liver isoform OS=Homo sapiens GN=CPT1A PE=1 SV=2 PF00755//PF01532 Choline/Carnitine o-acyltransferase//Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571//GO:0016746 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2430 Glycosyl hydrolase, family 47 Cluster-8309.36433 BP_3 139.17 0.44 15607 642914060 XP_008201528.1 14430 0.0e+00 PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3114 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00018//PF14604//PF00435//PF00307//PF11616 SH3 domain//Variant SH3 domain//Spectrin repeat//Calponin homology (CH) domain//WD repeat binding protein EZH2 GO:0006479//GO:0006554 protein methylation//lysine catabolic process GO:0018024//GO:0005515 histone-lysine N-methyltransferase activity//protein binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36435 BP_3 1799.00 57.45 1801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05808 Podoplanin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36436 BP_3 50.80 0.50 5218 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF01926//PF00983//PF03144 Elongation factor G, domain IV//50S ribosome-binding GTPase//Tymovirus coat protein//Elongation factor Tu domain 2 -- -- GO:0005525//GO:0005198 GTP binding//structural molecule activity GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.36437 BP_3 1714.52 13.60 6369 642924384 XP_008194273.1 3081 0.0e+00 PREDICTED: WD repeat-containing protein 59 [Tribolium castaneum]>gi|270007891|gb|EFA04339.1| hypothetical protein TcasGA2_TC014633 [Tribolium castaneum] 195162816 XM_002022214.1 101 2.07438e-42 Drosophila persimilis GL24697 (Dper\GL24697), mRNA -- -- -- -- Q9VKK2 1469 7.8e-161 WD repeat-containing protein 59 homolog OS=Drosophila melanogaster GN=CG4705 PE=1 SV=3 PF13520//PF05773//PF02459//PF00400//PF00324 Amino acid permease//RWD domain//Adenoviral DNA terminal protein//WD domain, G-beta repeat//Amino acid permease GO:0006810//GO:0055085//GO:0006865//GO:0003333//GO:0006260 transport//transmembrane transport//amino acid transport//amino acid transmembrane transport//DNA replication GO:0005515//GO:0015171//GO:0003677 protein binding//amino acid transmembrane transporter activity//DNA binding GO:0016020 membrane -- -- Cluster-8309.36438 BP_3 60.09 0.73 4262 642924384 XP_008194273.1 2461 1.2e-274 PREDICTED: WD repeat-containing protein 59 [Tribolium castaneum]>gi|270007891|gb|EFA04339.1| hypothetical protein TcasGA2_TC014633 [Tribolium castaneum] 195162816 XM_002022214.1 101 1.38488e-42 Drosophila persimilis GL24697 (Dper\GL24697), mRNA -- -- -- -- Q5ZLG9 1301 1.6e-141 WD repeat-containing protein 59 OS=Gallus gallus GN=WDR59 PE=2 SV=1 PF02459//PF05773//PF00324//PF00400//PF13520//PF01384 Adenoviral DNA terminal protein//RWD domain//Amino acid permease//WD domain, G-beta repeat//Amino acid permease//Phosphate transporter family GO:0003333//GO:0006260//GO:0055085//GO:0006865//GO:0006817//GO:0006810 amino acid transmembrane transport//DNA replication//transmembrane transport//amino acid transport//phosphate ion transport//transport GO:0005315//GO:0003677//GO:0015171//GO:0005515 inorganic phosphate transmembrane transporter activity//DNA binding//amino acid transmembrane transporter activity//protein binding GO:0016020 membrane -- -- Cluster-8309.36439 BP_3 27681.60 289.34 4903 642935120 XP_008197896.1 5408 0.0e+00 PREDICTED: vigilin [Tribolium castaneum]>gi|270013832|gb|EFA10280.1| hypothetical protein TcasGA2_TC012484 [Tribolium castaneum] 642935119 XM_008199674.1 989 0 PREDICTED: Tribolium castaneum vigilin (LOC658150), mRNA -- -- -- -- Q00341 3389 0.0e+00 Vigilin OS=Homo sapiens GN=HDLBP PE=1 SV=2 PF00013//PF13014//PF13184//PF07650 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2208 Vigilin Cluster-8309.36440 BP_3 6069.06 113.41 2871 91090794 XP_976004.1 328 1.7e-27 PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 1 [Tribolium castaneum]>gi|642935947|ref|XP_008198242.1| PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 1 [Tribolium castaneum] 642935946 XM_008200020.1 74 9.48974e-28 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q5KSL6 146 9.0e-08 Diacylglycerol kinase kappa OS=Homo sapiens GN=DGKK PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36441 BP_3 1234.74 4.74 12846 478258253 ENN78382.1 12264 0.0e+00 hypothetical protein YQE_05183, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 1476 2.4e-161 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF00041//PF00010//PF00069//PF06293//PF05038//PF07714 Immunoglobulin domain//Fibronectin type III domain//Helix-loop-helix DNA-binding domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Cytochrome Cytochrome b558 alpha-subunit//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0004672//GO:0020037//GO:0005524//GO:0005515//GO:0046983 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//heme binding//ATP binding//protein binding//protein dimerization activity GO:0016020 membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.36443 BP_3 4132.70 326.94 901 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36444 BP_3 204.81 1.02 9945 270013942 EFA10390.1 1611 1.0e-175 hypothetical protein TcasGA2_TC012621 [Tribolium castaneum] 642935672 XM_969594.3 364 0 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 11 (LOC663555), mRNA K03036 PSMD11, RPN6 26S proteasome regulatory subunit N6 http://www.genome.jp/dbget-bin/www_bget?ko:K03036 Q7KLV9 1341 8.5e-146 26S proteasome non-ATPase regulatory subunit 11 OS=Drosophila melanogaster GN=Rpn6 PE=1 SV=1 PF01399//PF05524 PCI domain//PEP-utilising enzyme, N-terminal GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515 protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.36445 BP_3 13359.90 93.55 7175 478250665 ENN71157.1 3127 0.0e+00 hypothetical protein YQE_12088, partial [Dendroctonus ponderosae] 642931311 XM_001813763.2 1529 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X26, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2919 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00769//PF00038//PF01576//PF09177//PF00487 Ezrin/radixin/moesin family//Intermediate filament protein//Myosin tail//Syntaxin 6, N-terminal//Fatty acid desaturase GO:0006629//GO:0048193 lipid metabolic process//Golgi vesicle transport GO:0003774//GO:0005198//GO:0008092 motor activity//structural molecule activity//cytoskeletal protein binding GO:0005737//GO:0016020//GO:0005882//GO:0019898//GO:0016459 cytoplasm//membrane//intermediate filament//extrinsic component of membrane//myosin complex -- -- Cluster-8309.36447 BP_3 1495.26 15.06 5078 642938278 XP_008192712.1 3186 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 988 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 Q08CW1 1818 2.1e-201 Serine/threonine-protein kinase tousled-like 2 OS=Xenopus tropicalis GN=tlk2 PE=2 SV=1 PF12142//PF07714//PF00069 Polyphenol oxidase middle domain//Protein tyrosine kinase//Protein kinase domain GO:0006118//GO:0055114//GO:0006468//GO:0006570 obsolete electron transport//oxidation-reduction process//protein phosphorylation//tyrosine metabolic process GO:0005524//GO:0004097//GO:0004672 ATP binding//catechol oxidase activity//protein kinase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.36448 BP_3 372.68 3.85 4962 642932399 XP_001812551.2 1585 5.2e-173 PREDICTED: uncharacterized protein LOC100142041 [Tribolium castaneum] 642932398 XM_001812499.2 48 4.68291e-13 PREDICTED: Tribolium castaneum uncharacterized LOC100142041 (LOC100142041), mRNA K17895 GATA3 GATA-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17895 P43694 207 1.3e-14 Transcription factor GATA-4 OS=Homo sapiens GN=GATA4 PE=1 SV=2 PF07776//PF00320//PF00979 Zinc-finger associated domain (zf-AD)//GATA zinc finger//Reovirus outer capsid protein, Sigma 3 GO:0019058//GO:0006355 viral life cycle//regulation of transcription, DNA-templated GO:0005198//GO:0043565//GO:0008270//GO:0003700 structural molecule activity//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36451 BP_3 504.00 8.24 3241 91089087 XP_971707.1 1963 5.0e-217 PREDICTED: uncharacterized protein LOC660378 [Tribolium castaneum]>gi|270011517|gb|EFA07965.1| hypothetical protein TcasGA2_TC005547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXG1 131 5.6e-06 Zinc finger protein hangover OS=Drosophila melanogaster GN=hang PE=1 SV=3 PF05485//PF07776 THAP domain//Zinc-finger associated domain (zf-AD) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.36452 BP_3 181.70 3.17 3054 332373100 AEE61691.1 1619 3.7e-177 unknown [Dendroctonus ponderosae] 632980128 XM_007908668.1 273 2.40398e-138 PREDICTED: Callorhinchus milii casein kinase 2, alpha 1 polypeptide (csnk2a1), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 2.8e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.36453 BP_3 17.17 0.80 1331 91083393 XP_967983.1 860 1.6e-89 PREDICTED: 60S ribosomal protein L8 [Tribolium castaneum]>gi|642923889|ref|XP_008193915.1| PREDICTED: 60S ribosomal protein L8 [Tribolium castaneum]>gi|270006898|gb|EFA03346.1| hypothetical protein TcasGA2_TC013327 [Tribolium castaneum] 401828841 JX122920.1 261 4.83855e-132 Phaedon cochleariae ribosomal protein L8 mRNA, partial cds K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q95V39 783 5.7e-82 60S ribosomal protein L8 OS=Spodoptera frugiperda GN=RpL8 PE=2 SV=1 PF03947//PF00181 Ribosomal Proteins L2, C-terminal domain//Ribosomal Proteins L2, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2309 60s ribosomal protein L2/L8 Cluster-8309.36455 BP_3 9113.67 387.96 1424 270005507 EFA01955.1 789 3.0e-81 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93113 612 4.1e-62 Glutathione S-transferase 1, isoform D OS=Anopheles gambiae GN=GstD1 PE=1 SV=1 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36456 BP_3 113.00 4.05 1638 571516260 XP_006569195.1 224 1.1e-15 PREDICTED: histidine-rich glycoprotein-like [Apis mellifera] -- -- -- -- -- -- -- -- -- P04929 188 6.9e-13 Histidine-rich glycoprotein OS=Plasmodium lophurae PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36458 BP_3 36.00 0.71 2749 642919398 XP_974094.3 1011 1.0e-106 PREDICTED: uncharacterized protein LOC662932 [Tribolium castaneum] 642919397 XM_969001.3 103 6.8729e-44 PREDICTED: Tribolium castaneum uncharacterized LOC662932 (LOC662932), mRNA -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36459 BP_3 2505.68 367.86 620 642925601 XP_001812139.2 238 1.0e-17 PREDICTED: uncharacterized protein LOC660114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46162 188 2.6e-13 Serine protease inhibitor I/II OS=Schistocerca gregaria PE=1 SV=1 PF06872//PF00093//PF05375 EspG protein//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) GO:0006508//GO:0009405 proteolysis//pathogenesis GO:0005515//GO:0030414//GO:0004197 protein binding//peptidase inhibitor activity//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.36460 BP_3 379.12 27.34 960 478259825 ENN79651.1 864 4.1e-90 hypothetical protein YQE_03910, partial [Dendroctonus ponderosae] -- -- -- -- -- K01697 E4.2.1.22, CBS cystathionine beta-synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01697 P32232 674 1.8e-69 Cystathionine beta-synthase OS=Rattus norvegicus GN=Cbs PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1252 Cystathionine beta-synthase and related enzymes Cluster-8309.36461 BP_3 9997.47 1432.83 628 91087257 XP_975530.1 818 5.7e-85 PREDICTED: 60S ribosomal protein L12 [Tribolium castaneum]>gi|270010582|gb|EFA07030.1| hypothetical protein TcasGA2_TC010002 [Tribolium castaneum] -- -- -- -- -- K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 E2RR58 704 3.9e-73 60S ribosomal protein L12 OS=Canis familiaris GN=RPL12 PE=1 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-8309.36466 BP_3 61912.82 951.19 3429 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1125 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF00983//PF01926//PF03144//PF03764 Tymovirus coat protein//50S ribosome-binding GTPase//Elongation factor Tu domain 2//Elongation factor G, domain IV -- -- GO:0005198//GO:0005525 structural molecule activity//GTP binding GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.36467 BP_3 14.36 0.32 2488 478258940 ENN78915.1 990 2.6e-104 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 Q8CHP8 494 3.5e-48 Phosphoglycolate phosphatase OS=Mus musculus GN=Pgp PE=1 SV=1 PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.36468 BP_3 2893.00 46.51 3290 478259697 ENN79541.1 1119 3.8e-119 hypothetical protein YQE_04004, partial [Dendroctonus ponderosae]>gi|546672024|gb|ERL84084.1| hypothetical protein D910_01418 [Dendroctonus ponderosae]>gi|546679827|gb|ERL90219.1| hypothetical protein D910_07572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P10379 415 6.6e-39 Protein unzipped OS=Drosophila melanogaster GN=uzip PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36469 BP_3 677.86 10.09 3531 91090882 XP_973170.1 1390 1.5e-150 PREDICTED: death-associated protein kinase related [Tribolium castaneum] 665818146 XM_008559662.1 44 5.55977e-11 PREDICTED: Microplitis demolitor serine/threonine-protein kinase 17B-like (LOC103578532), mRNA K08804 STK17 serine/threonine kinase 17 http://www.genome.jp/dbget-bin/www_bget?ko:K08804 Q0KHT7 743 6.6e-77 Death-associated protein kinase related OS=Drosophila melanogaster GN=Drak PE=1 SV=2 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.36470 BP_3 180.28 1.63 5612 642927190 XP_008195173.1 6372 0.0e+00 PREDICTED: DNA-directed RNA polymerase II subunit RPB1 [Tribolium castaneum]>gi|270010112|gb|EFA06560.1| hypothetical protein TcasGA2_TC009471 [Tribolium castaneum] 324120583 AB596930.1 1624 0 Lucidina biplagiata RPB1 mRNA for RNA polymerase II largest subunit, partial cds, isolate: E-19 K03006 RPB1, POLR2A DNA-directed RNA polymerase II subunit RPB1 http://www.genome.jp/dbget-bin/www_bget?ko:K03006 P04052 5669 0.0e+00 DNA-directed RNA polymerase II subunit RPB1 OS=Drosophila melanogaster GN=RpII215 PE=3 SV=4 PF04998//PF01381//PF04997//PF04992//PF05001//PF00623//PF04983//PF05000//PF04990 RNA polymerase Rpb1, domain 5//Helix-turn-helix//RNA polymerase Rpb1, domain 1//RNA polymerase Rpb1, domain 6//RNA polymerase Rpb1 C-terminal repeat//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 7 GO:0006351//GO:0006144//GO:0006366//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//transcription from RNA polymerase II promoter//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0043565 DNA-directed RNA polymerase activity//DNA binding//sequence-specific DNA binding GO:0005665//GO:0005730 DNA-directed RNA polymerase II, core complex//nucleolus KOG0260 RNA polymerase II, large subunit Cluster-8309.36472 BP_3 12.26 0.88 965 282165794 NP_001164136.1 473 8.9e-45 chickadee [Tribolium castaneum] 282165793 NM_001170665.1 164 2.90536e-78 Tribolium castaneum chickadee (chic), mRNA K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 Q6QEJ7 446 4.9e-43 Profilin OS=Apis mellifera PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1755 Profilin Cluster-8309.36473 BP_3 5.00 2.11 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36474 BP_3 1765.97 13.10 6788 478252889 ENN73274.1 4014 0.0e+00 hypothetical protein YQE_10104, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.3e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025//PF14604//PF00018 Phage protein C//Variant SH3 domain//SH3 domain GO:0019073 viral DNA genome packaging GO:0005515 protein binding -- -- -- -- Cluster-8309.36476 BP_3 489.87 9.56 2761 91079244 XP_971138.1 1563 1.0e-170 PREDICTED: dnaJ homolog subfamily C member 22 [Tribolium castaneum]>gi|270003554|gb|EFA00002.1| hypothetical protein TcasGA2_TC002805 [Tribolium castaneum] -- -- -- -- -- K19370 DNAJC22 DnaJ homolog subfamily C member 22 http://www.genome.jp/dbget-bin/www_bget?ko:K19370 A9ULE9 305 3.2e-26 DnaJ homolog subfamily C member 22 OS=Xenopus tropicalis GN=dnajc22 PE=2 SV=1 PF01757 Acyltransferase family GO:0006457 protein folding GO:0031072//GO:0051082//GO:0016747 heat shock protein binding//unfolded protein binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.36477 BP_3 16971.00 1950.93 711 91084049 XP_967339.1 995 1.9e-105 PREDICTED: 40S ribosomal protein S8 [Tribolium castaneum]>gi|270008005|gb|EFA04453.1| hypothetical protein TcasGA2_TC014757 [Tribolium castaneum] 642924821 XM_962246.3 329 3.99801e-170 PREDICTED: Tribolium castaneum 40S ribosomal protein S8 (LOC655685), mRNA K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 O76756 908 9.7e-97 40S ribosomal protein S8 OS=Apis mellifera GN=RpS8 PE=2 SV=2 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3283 40S ribosomal protein S8 Cluster-8309.36479 BP_3 3.00 0.68 505 669214630 CDW61305.1 215 3.8e-15 hypothetical protein TTRE_0000975601 [Trichuris trichiura] 296882003 HM046546.1 462 0 Lamiomimus gottschei voucher CNE1029 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM6 187 2.8e-13 Protein TAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAR1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36480 BP_3 317.34 4.34 3815 642913883 XP_975200.2 1600 7.3e-175 PREDICTED: forkhead box protein O isoform X1 [Tribolium castaneum] 642913882 XM_970107.2 416 0 PREDICTED: Tribolium castaneum forkhead box protein O (LOC664090), transcript variant X1, mRNA K09408 FOXO3 forkhead box protein O3 http://www.genome.jp/dbget-bin/www_bget?ko:K09408 B4MB78 974 1.2e-103 Forkhead box protein O OS=Drosophila virilis GN=foxo PE=3 SV=1 PF01342//PF00250 SAND domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.36481 BP_3 18.68 0.45 2302 761896177 AJP75146.1 1305 7.1e-141 alanine aminotransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 Q6NYL5 894 1.3e-94 Alanine aminotransferase 2-like OS=Danio rerio GN=gpt2l PE=2 SV=2 PF00155//PF01212 Aminotransferase class I and II//Beta-eliminating lyase GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0258 Alanine aminotransferase Cluster-8309.36482 BP_3 3.00 0.74 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.36485 BP_3 8882.95 281.26 1814 264667333 ACY71252.1 883 4.8e-92 ribosomal protein L17 [Chrysomela tremula] -- -- -- -- -- K02880 RP-L17e, RPL17 large subunit ribosomal protein L17e http://www.genome.jp/dbget-bin/www_bget?ko:K02880 Q4GXH6 855 3.5e-90 60S ribosomal protein L17 OS=Biphyllus lunatus GN=RpL17 PE=2 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3353 60S ribosomal protein L22 Cluster-8309.36486 BP_3 912.36 31.01 1710 549438535 AGX25156.1 1856 6.8e-205 thiol-disulfide isomerase [Leptinotarsa decemlineata] 157137765 XM_001663984.1 131 1.15539e-59 Aedes aegypti AAEL013845-RA partial mRNA K17264 ERP44, TXNDC4 endoplasmic reticulum resident protein 44 http://www.genome.jp/dbget-bin/www_bget?ko:K17264 Q9D1Q6 1046 2.3e-112 Endoplasmic reticulum resident protein 44 OS=Mus musculus GN=Erp44 PE=1 SV=1 PF01216//PF00085 Calsequestrin//Thioredoxin GO:0045454 cell redox homeostasis GO:0005509 calcium ion binding -- -- KOG0912 Thiol-disulfide isomerase and thioredoxin Cluster-8309.36488 BP_3 953.28 15.22 3310 570341948 AHE77372.1 614 1.4e-60 small heat shock protein [Lissorhoptrus oryzophilus] 570341961 KC620429.1 60 6.64258e-20 Lissorhoptrus oryzophilus small heat shock protein (HSP27e) mRNA, partial cds K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 351 1.8e-31 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF01873//PF00525//PF09066 Domain found in IF2B/IF5//Alpha crystallin A chain, N terminal//Beta2-adaptin appendage, C-terminal sub-domain GO:0006413//GO:0006886//GO:0006446//GO:0016192//GO:0007423 translational initiation//intracellular protein transport//regulation of translational initiation//vesicle-mediated transport//sensory organ development GO:0005212//GO:0003743 structural constituent of eye lens//translation initiation factor activity GO:0005840//GO:0030131 ribosome//clathrin adaptor complex -- -- Cluster-8309.36489 BP_3 1347.24 22.77 3143 189235372 XP_968511.2 1112 2.3e-118 PREDICTED: nucleobindin-2 [Tribolium castaneum]>gi|270004247|gb|EFA00695.1| hypothetical protein TcasGA2_TC003574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80303 492 7.5e-48 Nucleobindin-2 OS=Homo sapiens GN=NUCB2 PE=1 SV=2 PF13202//PF13499//PF13833//PF13405//PF00036 EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG3866 DNA-binding protein of the nucleobindin family Cluster-8309.36490 BP_3 28297.00 1086.54 1547 726971106 AIY53682.1 702 4.0e-71 myosin regulatory light chain 2 [Monochamus alternatus] 726971105 KM371003.1 567 0 Monochamus alternatus clone WHJ1 myosin regulatory light chain 2 mRNA, complete cds K12754 MYL7 myosin regulatory light chain 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12754 Q1HPS0 533 6.5e-53 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF13499//PF00036//PF13833//PF13405//PF13202 EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.36491 BP_3 0.55 14.85 219 291170320 ADD82416.1 364 8.7e-33 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170319 GU584933.1 202 4.38814e-100 Batocera horsfieldi minus-C odorant binding protein 3 mRNA, complete cds -- -- -- -- -- -- -- -- PF00018 SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36492 BP_3 66.78 2.88 1411 156481748 ABU68467.1 1247 2.3e-134 adenine nucleotide translocase [Monochamus alternatus] 156481747 EU093076.1 798 0 Monochamus alternatus adenine nucleotide translocase mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q26365 1142 1.4e-123 ADP,ATP carrier protein OS=Drosophila melanogaster GN=sesB PE=2 SV=4 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.36494 BP_3 146.35 1.17 6298 826464184 XP_012534808.1 1234 3.3e-132 PREDICTED: titin [Monomorium pharaonis] 642936078 XM_008200072.1 169 3.24339e-80 PREDICTED: Tribolium castaneum titin (LOC663321), transcript variant X2, mRNA -- -- -- -- Q9I7U4 184 7.8e-12 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36496 BP_3 7760.32 469.75 1088 282165794 NP_001164136.1 635 1.6e-63 chickadee [Tribolium castaneum] 282165793 NM_001170665.1 275 6.49427e-140 Tribolium castaneum chickadee (chic), mRNA K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 Q6QEJ7 603 3.5e-61 Profilin OS=Apis mellifera PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1755 Profilin Cluster-8309.36498 BP_3 189.75 1.75 5516 642926413 XP_008191952.1 2921 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X1 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.63803e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 4.1e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.36499 BP_3 2518.68 55.76 2469 478257427 ENN77583.1 2448 2.2e-273 hypothetical protein YQE_05879, partial [Dendroctonus ponderosae]>gi|546685706|gb|ERL95167.1| hypothetical protein D910_12436 [Dendroctonus ponderosae] -- -- -- -- -- K00294 E1.2.1.88 1-pyrroline-5-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00294 P30038 1718 4.0e-190 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens GN=ALDH4A1 PE=1 SV=3 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2455 Delta-1-pyrroline-5-carboxylate dehydrogenase Cluster-8309.365 BP_3 7.00 0.90 667 328718738 XP_003246562.1 141 1.9e-06 PREDICTED: longitudinals lacking protein, isoform G-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.36500 BP_3 6837.11 123.18 2967 478249731 ENN70239.1 482 2.5e-45 hypothetical protein YQE_13023, partial [Dendroctonus ponderosae]>gi|546677413|gb|ERL88250.1| hypothetical protein D910_05638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y639 172 9.0e-11 Neuroplastin OS=Homo sapiens GN=NPTN PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36501 BP_3 8.00 4.09 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36502 BP_3 677.57 5.07 6730 270002717 EEZ99164.1 9016 0.0e+00 hypothetical protein TcasGA2_TC016163 [Tribolium castaneum] 642912219 XM_965461.2 1695 0 PREDICTED: Tribolium castaneum putative U5 small nuclear ribonucleoprotein 200 kDa helicase (LOC659129), mRNA K12854 SNRNP200, BRR2 pre-mRNA-splicing helicase BRR2 http://www.genome.jp/dbget-bin/www_bget?ko:K12854 Q9VUV9 8008 0.0e+00 Putative U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Drosophila melanogaster GN=l(3)72Ab PE=2 SV=4 PF00270//PF00437//PF00580//PF01695//PF04851//PF03146//PF02562 DEAD/DEAH box helicase//Type II/IV secretion system protein//UvrD/REP helicase N-terminal domain//IstB-like ATP binding protein//Type III restriction enzyme, res subunit//Agrin NtA domain//PhoH-like protein GO:0006810//GO:0007213//GO:0043113 transport//G-protein coupled acetylcholine receptor signaling pathway//receptor clustering GO:0043236//GO:0003677//GO:0016787//GO:0005524//GO:0003676 laminin binding//DNA binding//hydrolase activity//ATP binding//nucleic acid binding -- -- KOG0951 RNA helicase BRR2, DEAD-box superfamily Cluster-8309.36503 BP_3 3241.22 32.16 5149 642915997 XP_008190849.1 3679 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O01761 593 2.4e-59 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF15202//PF06220//PF13895//PF00041 Adipogenin//U1 zinc finger//Immunoglobulin domain//Fibronectin type III domain GO:0045444 fat cell differentiation GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.36505 BP_3 9565.00 35.84 13156 642923233 XP_008193668.1 6238 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 7 isoform X4 [Tribolium castaneum] 642923232 XM_008195446.1 999 0 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X4, mRNA K14437 CHD7 chromodomain-helicase-DNA-binding protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14437 A2AJK6 2939 0.0e+00 Chromodomain-helicase-DNA-binding protein 7 OS=Mus musculus GN=Chd7 PE=1 SV=1 PF08074//PF00176//PF07533//PF04851 CHDCT2 (NUC038) domain//SNF2 family N-terminal domain//BRK domain//Type III restriction enzyme, res subunit GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0016817//GO:0016818//GO:0016787//GO:0003677//GO:0005524//GO:0005515 zinc ion binding//hydrolase activity, acting on acid anhydrides//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//hydrolase activity//DNA binding//ATP binding//protein binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.36507 BP_3 894.28 12.58 3718 642918852 XP_008191614.1 1788 1.1e-196 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76329 167 4.3e-10 Interaptin OS=Dictyostelium discoideum GN=abpD PE=1 SV=1 PF04434//PF01414 SWIM zinc finger//Delta serrate ligand GO:0007154 cell communication GO:0008270 zinc ion binding GO:0016020 membrane -- -- Cluster-8309.36509 BP_3 54.51 3.83 978 91084843 XP_966905.1 740 9.9e-76 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 328 2.4e-29 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.36510 BP_3 4061.93 52.57 4016 91084051 XP_967428.1 4787 0.0e+00 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BKC5 2861 0.0e+00 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF02985//PF09044//PF01602//PF00514 HEAT repeat//Kp4//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0006886//GO:0016192//GO:0009405 intracellular protein transport//vesicle-mediated transport//pathogenesis GO:0005515 protein binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.36514 BP_3 159.65 1.49 5466 642934860 XP_971174.2 3111 0.0e+00 PREDICTED: NADPH--cytochrome P450 reductase isoform X1 [Tribolium castaneum] 198472181 XM_001355830.2 178 2.79396e-85 Drosophila pseudoobscura pseudoobscura GA11069 (Dpse\GA11069), partial mRNA K00327 POR NADPH-ferrihemoprotein reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00327 Q27597 2572 8.4e-289 NADPH--cytochrome P450 reductase OS=Drosophila melanogaster GN=Cpr PE=2 SV=2 PF00175//PF00258//PF00667 Oxidoreductase NAD-binding domain//Flavodoxin//FAD binding domain GO:0055114 oxidation-reduction process GO:0010181//GO:0016491 FMN binding//oxidoreductase activity -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.36516 BP_3 1171.93 11.66 5138 642919375 XP_008191845.1 3479 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P53767 852 2.2e-89 Vascular endothelial growth factor receptor 1 OS=Rattus norvegicus GN=Flt1 PE=2 SV=1 PF00069//PF07714//PF02480//PF13895//PF01325 Protein kinase domain//Protein tyrosine kinase//Alphaherpesvirus glycoprotein E//Immunoglobulin domain//Iron dependent repressor, N-terminal DNA binding domain GO:0006468 protein phosphorylation GO:0003677//GO:0005524//GO:0004672//GO:0005515 DNA binding//ATP binding//protein kinase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.36517 BP_3 2076.51 5.58 18233 642929802 XP_008195983.1 16014 0.0e+00 PREDICTED: dynein heavy chain, cytoplasmic isoform X2 [Tribolium castaneum] 642929801 XM_008197761.1 3152 0 PREDICTED: Tribolium castaneum dynein heavy chain (LOC664489), transcript variant X2, mRNA K10413 DYNC1H dynein heavy chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10413 P37276 14288 0.0e+00 Dynein heavy chain, cytoplasmic OS=Drosophila melanogaster GN=Dhc64C PE=2 SV=2 PF08702//PF04513//PF00910//PF02477//PF00005//PF07926//PF03767//PF01496//PF03028//PF06810//PF13851//PF00437//PF06009//PF12106//PF07851//PF06008//PF01580//PF10473//PF06160//PF02932//PF00004//PF04111//PF05791//PF07728//PF01695 Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//RNA helicase//Nucleocapsid N protein//ABC transporter//TPR/MLP1/MLP2-like protein//HAD superfamily, subfamily IIIB (Acid phosphatase)//V-type ATPase 116kDa subunit family//Dynein heavy chain and region D6 of dynein motor//Phage minor structural protein GP20//Growth-arrest specific micro-tubule binding//Type II/IV secretion system protein//Laminin Domain II//Colicin C terminal ribonuclease domain//TMPIT-like protein//Laminin Domain I//FtsK/SpoIIIE family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Neurotransmitter-gated ion-channel transmembrane region//ATPase family associated with various cellular activities (AAA)//Autophagy protein Apg6//Bacillus haemolytic enterotoxin (HBL)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006771//GO:0030168//GO:0000921//GO:0048870//GO:0006606//GO:0045995//GO:0015992//GO:0019497//GO:0007155//GO:0030155//GO:0006811//GO:0015991//GO:0007017//GO:0051252//GO:0007165//GO:0009405//GO:0007018//GO:0030334//GO:0006810//GO:0051258//GO:0006914 riboflavin metabolic process//platelet activation//septin ring assembly//cell motility//protein import into nucleus//regulation of embryonic development//proton transport//hexachlorocyclohexane metabolic process//cell adhesion//regulation of cell adhesion//ion transport//ATP hydrolysis coupled proton transport//microtubule-based process//regulation of RNA metabolic process//signal transduction//pathogenesis//microtubule-based movement//regulation of cell migration//transport//protein polymerization//autophagy GO:0030674//GO:0003777//GO:0005102//GO:0016887//GO:0003993//GO:0005524//GO:0008134//GO:0045502//GO:0042803//GO:0003724//GO:0003677//GO:0003723//GO:0015078//GO:0000166//GO:0004540//GO:0005198 protein binding, bridging//microtubule motor activity//receptor binding//ATPase activity//acid phosphatase activity//ATP binding//transcription factor binding//dynein binding//protein homodimerization activity//RNA helicase activity//DNA binding//RNA binding//hydrogen ion transmembrane transporter activity//nucleotide binding//ribonuclease activity//structural molecule activity GO:0030286//GO:0005667//GO:0005577//GO:0019013//GO:0019028//GO:0016020//GO:0033179//GO:0019031//GO:0005874//GO:0031514//GO:0016021//GO:0005940 dynein complex//transcription factor complex//fibrinogen complex//viral nucleocapsid//viral capsid//membrane//proton-transporting V-type ATPase, V0 domain//viral envelope//microtubule//motile cilium//integral component of membrane//septin ring KOG3595 Dyneins, heavy chain Cluster-8309.36519 BP_3 166.56 0.83 10003 642934185 XP_008199643.1 2538 3.3e-283 PREDICTED: uncharacterized protein LOC657682 isoform X4 [Tribolium castaneum] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 1.7e-215 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF00130//PF10510//PF17095//PF07649//PF00628//PF00183//PF05192//PF04857 Phorbol esters/diacylglycerol binding domain (C1 domain)//Phosphatidylinositol-glycan biosynthesis class S protein//Spectrin-binding region of Ca2+-Calmodulin//C1-like domain//PHD-finger//Hsp90 protein//MutS domain III//CAF1 family ribonuclease GO:0016255//GO:0006298//GO:0006950//GO:0006457//GO:0031175//GO:0055114//GO:0035556 attachment of GPI anchor to protein//mismatch repair//response to stress//protein folding//neuron projection development//oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0030507//GO:0005524//GO:0005516//GO:0047134//GO:0051082//GO:0030983 protein binding//spectrin binding//ATP binding//calmodulin binding//protein-disulfide reductase activity//unfolded protein binding//mismatched DNA binding GO:0005634//GO:0042765//GO:0008091 nucleus//GPI-anchor transamidase complex//spectrin KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.3652 BP_3 3.00 0.49 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.36520 BP_3 91.96 1.87 2662 546674950 ERL86223.1 2220 6.5e-247 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 1.00893e-111 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1683 5.0e-186 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF00390//PF03949 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain GO:0006099//GO:0015976//GO:0006090//GO:0055114//GO:0006108 tricarboxylic acid cycle//carbon utilization//pyruvate metabolic process//oxidation-reduction process//malate metabolic process GO:0004471//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.36523 BP_3 2160.39 21.80 5069 642917533 XP_008191243.1 1126 8.9e-120 PREDICTED: myosin-3 [Tribolium castaneum] 462291896 APGK01053945.1 99 2.13356e-41 Dendroctonus ponderosae Seq01053955, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36524 BP_3 4294.33 37.14 5865 642935884 XP_008198212.1 3942 0.0e+00 PREDICTED: sterile alpha and TIR motif-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IDD9 2775 1.9e-312 Sterile alpha and TIR motif-containing protein 1 OS=Drosophila melanogaster GN=Ect4 PE=2 SV=1 PF07647//PF00536//PF06624//PF00514//PF13676 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Ribosome associated membrane protein RAMP4//Armadillo/beta-catenin-like repeat//TIR domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG3678 SARM protein (with sterile alpha and armadillo motifs) Cluster-8309.36525 BP_3 5.80 0.31 1192 674303998 AIL23530.1 1146 1.0e-122 ribosomal protein S3 [Tenebrio molitor] 642920571 XM_008194244.1 198 4.5389e-97 PREDICTED: Tribolium castaneum ribosomal protein S3 (RpS3), transcript variant X1, mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 P02350 989 6.6e-106 40S ribosomal protein S3-A OS=Xenopus laevis GN=rps3-a PE=2 SV=2 PF07650 KH domain -- -- GO:0003723 RNA binding -- -- KOG3181 40S ribosomal protein S3 Cluster-8309.36526 BP_3 195018.00 6472.45 1744 780036326 XP_011667444.1 2193 5.8e-244 PREDICTED: tubulin alpha-1 chain-like [Strongylocentrotus purpuratus] 155573639 EU073050.1 1093 0 Monochamus alternatus alpha-tubulin 1 mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q9JJZ2 2057 1.4e-229 Tubulin alpha-8 chain OS=Mus musculus GN=Tuba8 PE=1 SV=1 PF13912//PF00091 C2H2-type zinc finger//Tubulin/FtsZ family, GTPase domain -- -- GO:0003924//GO:0046872 GTPase activity//metal ion binding -- -- KOG1376 Alpha tubulin Cluster-8309.36527 BP_3 1416.59 5.34 13086 478258253 ENN78382.1 13121 0.0e+00 hypothetical protein YQE_05183, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 1476 2.5e-161 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00010//PF00041//PF13895//PF05038//PF00069//PF06293//PF07714 Helix-loop-helix DNA-binding domain//Fibronectin type III domain//Immunoglobulin domain//Cytochrome Cytochrome b558 alpha-subunit//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0020037//GO:0004672//GO:0005524//GO:0046983//GO:0005515 phosphotransferase activity, alcohol group as acceptor//heme binding//protein kinase activity//ATP binding//protein dimerization activity//protein binding GO:0016020 membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.36528 BP_3 533.70 8.35 3371 642914172 XP_008201574.1 2306 8.8e-257 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 952 3.7e-101 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF01738//PF15182 Dienelactone hydrolase family//Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.36529 BP_3 118.13 2.97 2206 270002097 EEZ98544.1 592 3.2e-58 hypothetical protein TcasGA2_TC001048 [Tribolium castaneum] 642913817 XM_008202950.1 217 2.33472e-107 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 Q24654 425 3.1e-40 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13499//PF13405 EF-hand domain pair//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.36531 BP_3 29.99 0.41 3813 546676365 ERL87392.1 1940 2.7e-214 hypothetical protein D910_04787, partial [Dendroctonus ponderosae] 828210619 XM_004208630.2 127 4.35823e-57 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 1339 5.5e-146 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF07714//PF06293//PF00069//PF09573 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//TaqI restriction endonuclease GO:0009307//GO:0006308//GO:0006468 DNA restriction-modification system//DNA catabolic process//protein phosphorylation GO:0016773//GO:0004672//GO:0009036//GO:0003677//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//Type II site-specific deoxyribonuclease activity//DNA binding//ATP binding GO:0016020//GO:0009359 membrane//Type II site-specific deoxyribonuclease complex KOG4717 Serine/threonine protein kinase Cluster-8309.36535 BP_3 2534.44 29.12 4487 642919149 XP_008191757.1 5346 0.0e+00 PREDICTED: phosphoribosylformylglycinamidine synthase-like [Tribolium castaneum] 703110936 XM_010101429.1 38 1.53267e-07 Morus notabilis putative phosphoribosylformylglycinamidine synthase partial mRNA K01952 purL, PFAS phosphoribosylformylglycinamidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01952 P35421 3627 0.0e+00 Phosphoribosylformylglycinamidine synthase OS=Drosophila melanogaster GN=ade2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1907 Phosphoribosylformylglycinamidine synthase Cluster-8309.36536 BP_3 28470.29 1200.29 1435 642924457 XP_008194306.1 1652 2.6e-181 PREDICTED: 60S ribosomal protein L4 [Tribolium castaneum]>gi|270006788|gb|EFA03236.1| hypothetical protein TcasGA2_TC013168 [Tribolium castaneum] 70909604 AM048989.1 303 2.34729e-155 Eucinetus sp. APV-2005 mRNA for ribosomal protein L4e (rpL4e gene) K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P09180 1314 1.6e-143 60S ribosomal protein L4 OS=Drosophila melanogaster GN=RpL4 PE=1 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-8309.36537 BP_3 28.05 0.51 2943 642916810 XP_967695.2 1570 1.7e-171 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 1086 9.3e-117 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737//PF07655 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein//Secretin N-terminal domain GO:0009297//GO:0015979//GO:0050821 pilus assembly//photosynthesis//protein stabilization GO:0005515//GO:0042301 protein binding//phosphate ion binding GO:0019867//GO:0009523//GO:0016020 outer membrane//photosystem II//membrane KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.36539 BP_3 8878.54 200.51 2426 270014632 EFA11080.1 1673 1.6e-183 hypothetical protein TcasGA2_TC004676 [Tribolium castaneum] -- -- -- -- -- K05768 GSN gelsolin http://www.genome.jp/dbget-bin/www_bget?ko:K05768 Q07171 1086 7.6e-117 Gelsolin OS=Drosophila melanogaster GN=Gel PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0443 Actin regulatory proteins (gelsolin/villin family) Cluster-8309.36540 BP_3 35.00 1.10 1823 385199964 AFI45030.1 1313 6.6e-142 cytochrome P450 CYP6CR2 [Dendroctonus ponderosae] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 892 1.8e-94 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.36541 BP_3 13991.90 664.26 1307 91089929 XP_973045.1 495 3.4e-47 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00436 Single-strand binding protein family -- -- GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.36543 BP_3 96028.00 749.76 6465 556505467 YP_008757564.1 1815 1.5e-199 NADH dehydrogenase subunit 4 (mitochondrion) [Batocera lineolata]>gi|359294290|gb|AEV21659.1| NADH dehydrogenase subunit 4 [Batocera lineolata] 359294281 JN986793.1 5035 0 Batocera lineolata mitochondrion, complete genome K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P07707 1224 2.0e-132 NADH-ubiquinone oxidoreductase chain 4 OS=Drosophila yakuba GN=mt:ND4 PE=3 SV=1 PF00420//PF02272//PF06455//PF13965 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L//DHHA1 domain//NADH dehydrogenase subunit 5 C-terminus//dsRNA-gated channel SID-1 GO:0006120//GO:0042773//GO:0015931//GO:0033227//GO:0015992//GO:0055114//GO:0006744//GO:0006814 mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled electron transport//nucleobase-containing compound transport//dsRNA transport//proton transport//oxidation-reduction process//ubiquinone biosynthetic process//sodium ion transport GO:0016651//GO:0008137//GO:0003676//GO:0051033 oxidoreductase activity, acting on NAD(P)H//NADH dehydrogenase (ubiquinone) activity//nucleic acid binding//RNA transmembrane transporter activity GO:0016021 integral component of membrane KOG4845 NADH dehydrogenase, subunit 4 Cluster-8309.36545 BP_3 24062.21 813.73 1717 33112583 AAP94047.1 1461 4.3e-159 cathepsin-L-like cysteine peptidase 03 [Tenebrio molitor] 33112582 AY332271.1 252 6.32425e-127 Tenebrio molitor cathepsin-L-like cysteine peptidase 03 mRNA, complete cds K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 1253 2.3e-136 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF02347//PF00112//PF03051 Glycine cleavage system P-protein//Papain family cysteine protease//Peptidase C1-like family GO:0006546//GO:0006544//GO:0055114//GO:0006566//GO:0006508//GO:0006563 glycine catabolic process//glycine metabolic process//oxidation-reduction process//threonine metabolic process//proteolysis//L-serine metabolic process GO:0004197//GO:0004375//GO:0008234 cysteine-type endopeptidase activity//glycine dehydrogenase (decarboxylating) activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.36546 BP_3 1428.53 6.57 10764 270001100 EEZ97547.1 2545 5.4e-284 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] 170032990 XM_001844311.1 225 4.11724e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 9.9e-217 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF01378//PF00412//PF13180//PF10468//PF00560//PF13855//PF00595//PF14304 B domain//LIM domain//PDZ domain//Carboxypeptidase inhibitor I68//Leucine Rich Repeat//Leucine rich repeat//PDZ domain (Also known as DHR or GLGF)//Transcription termination and cleavage factor C-terminal GO:0007596//GO:0031124//GO:0010951 blood coagulation//mRNA 3'-end processing//negative regulation of endopeptidase activity GO:0005515//GO:0008191//GO:0008270 protein binding//metalloendopeptidase inhibitor activity//zinc ion binding GO:0005618 cell wall KOG0619 FOG: Leucine rich repeat Cluster-8309.36547 BP_3 2954.00 145.69 1269 91086607 XP_973974.1 276 8.2e-22 PREDICTED: V-type proton ATPase subunit G [Tribolium castaneum]>gi|270009777|gb|EFA06225.1| hypothetical protein TcasGA2_TC009074 [Tribolium castaneum] -- -- -- -- -- K02152 ATPeV1G, ATP6G V-type H+-transporting ATPase subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K02152 Q25532 245 1.3e-19 V-type proton ATPase subunit G OS=Manduca sexta PE=3 SV=1 PF04857//PF14942//PF07464//PF03938//PF07851//PF04111 CAF1 family ribonuclease//Organelle biogenesis, Muted-like protein//Apolipophorin-III precursor (apoLp-III)//Outer membrane protein (OmpH-like)//TMPIT-like protein//Autophagy protein Apg6 GO:0006869//GO:0006914 lipid transport//autophagy GO:0008289//GO:0051082 lipid binding//unfolded protein binding GO:0005634//GO:0016021//GO:0005576//GO:0030133//GO:0031083 nucleus//integral component of membrane//extracellular region//transport vesicle//BLOC-1 complex KOG1772 Vacuolar H+-ATPase V1 sector, subunit G Cluster-8309.36548 BP_3 9544.12 198.69 2607 642920667 XP_008192513.1 828 1.6e-85 PREDICTED: tropomyosin-1, isoforms 33/34 isoform X5 [Tribolium castaneum] 642920666 XM_008194291.1 338 1.50771e-174 PREDICTED: Tribolium castaneum troponin I (LOC656510), transcript variant X5, mRNA -- -- -- -- P36188 522 2.1e-51 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF01529 Troponin//DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.36549 BP_3 140.98 1.28 5594 642935990 XP_008198259.1 4373 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1884 5.2e-209 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00632//PF00397 HECT-domain (ubiquitin-transferase)//WW domain GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.36551 BP_3 251.09 5.00 2712 642920676 XP_008192517.1 490 2.7e-46 PREDICTED: troponin I isoform X10 [Tribolium castaneum] 332376704 BT128535.1 118 3.10973e-52 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 439 9.0e-42 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00832//PF00992 Ribosomal L39 protein//Troponin GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005861//GO:0005622//GO:0005840 troponin complex//intracellular//ribosome KOG3977 Troponin I Cluster-8309.36552 BP_3 168.68 3.36 2712 332374296 AEE62289.1 1127 3.7e-120 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 1.8e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.36553 BP_3 21.03 0.48 2384 642919704 XP_008192030.1 1789 5.5e-197 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] 807042760 XM_012306425.1 116 3.53223e-51 PREDICTED: Ceratitis capitata serine/threonine-protein kinase par-1 (LOC101453227), transcript variant X3, mRNA K16311 SIK2 serine/threonine-protein kinase SIK2 http://www.genome.jp/dbget-bin/www_bget?ko:K16311 Q9H0K1 1251 5.5e-136 Serine/threonine-protein kinase SIK2 OS=Homo sapiens GN=SIK2 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004674//GO:0004672//GO:0016773//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0586 Serine/threonine protein kinase Cluster-8309.36554 BP_3 313.44 4.81 3430 642919704 XP_008192030.1 434 1.1e-39 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15925 SOSS complex subunit C GO:0006974//GO:0006281 cellular response to DNA damage stimulus//DNA repair GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0070876//GO:0005634 SOSS complex//nucleus -- -- Cluster-8309.36556 BP_3 739.56 13.23 2987 642918139 XP_008191383.1 969 8.4e-102 PREDICTED: hepatic leukemia factor-like, partial [Tribolium castaneum] 462392704 APGK01017996.1 66 2.76596e-23 Dendroctonus ponderosae Seq01018006, whole genome shotgun sequence K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q64709 357 3.2e-32 Hepatic leukemia factor OS=Rattus norvegicus GN=Hlf PE=2 SV=1 PF07716//PF00170//PF09726//PF03131 Basic region leucine zipper//bZIP transcription factor//Transmembrane protein//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.36557 BP_3 467.13 5.79 4178 291170320 ADD82416.1 712 7.5e-72 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170319 GU584933.1 402 0 Batocera horsfieldi minus-C odorant binding protein 3 mRNA, complete cds -- -- -- -- -- -- -- -- PF01395//PF01384 PBP/GOBP family//Phosphate transporter family GO:0006817 phosphate ion transport GO:0005315//GO:0005549 inorganic phosphate transmembrane transporter activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.36558 BP_3 77.80 0.65 6087 642910289 XP_008198706.1 2334 9.0e-260 PREDICTED: U2 snRNP-associated SURP motif-containing protein-like [Tribolium castaneum] -- -- -- -- -- K12842 SR140 U2-associated protein SR140 http://www.genome.jp/dbget-bin/www_bget?ko:K12842 Q5R7X2 1542 2.5e-169 U2 snRNP-associated SURP motif-containing protein OS=Pongo abelii GN=U2SURP PE=2 SV=1 PF11051//PF01805//PF16367//PF01501//PF00076 Mannosyltransferase putative//Surp module//RNA recognition motif//Glycosyl transferase family 8//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006486//GO:0006396 protein glycosylation//RNA processing GO:0003676//GO:0016757//GO:0003723 nucleic acid binding//transferase activity, transferring glycosyl groups//RNA binding -- -- KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains Cluster-8309.36559 BP_3 602.00 12.88 2545 642926997 XP_008195097.1 2168 6.7e-241 PREDICTED: mitotic spindle assembly checkpoint protein MAD1 [Tribolium castaneum]>gi|270010044|gb|EFA06492.1| hypothetical protein TcasGA2_TC009389 [Tribolium castaneum] -- -- -- -- -- K06638 MAD1L mitotic spindle assembly checkpoint protein MAD1 http://www.genome.jp/dbget-bin/www_bget?ko:K06638 Q80YF0 486 3.0e-47 Mitotic spindle assembly checkpoint protein MAD1 OS=Cricetulus griseus GN=MAD1L1 PE=2 SV=1 PF00038//PF05557//PF08287 Intermediate filament protein//Mitotic checkpoint protein//Spc19 GO:0008608//GO:0007094 attachment of spindle microtubules to kinetochore//mitotic spindle assembly checkpoint GO:0005198 structural molecule activity GO:0042729//GO:0005882//GO:0005876 DASH complex//intermediate filament//spindle microtubule KOG4593 Mitotic checkpoint protein MAD1 Cluster-8309.36560 BP_3 5331.06 101.79 2816 91081945 XP_966990.1 2785 0.0e+00 PREDICTED: ATP-binding cassette sub-family F member 2 [Tribolium castaneum]>gi|270007325|gb|EFA03773.1| hypothetical protein TcasGA2_TC013884 [Tribolium castaneum] 642921870 XM_961897.3 497 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family F member 2 (LOC655357), mRNA K06185 ABCF2 ATP-binding cassette, subfamily F, member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06185 Q9UG63 2156 7.5e-241 ATP-binding cassette sub-family F member 2 OS=Homo sapiens GN=ABCF2 PE=1 SV=2 PF01716//PF00025//PF00004//PF01926//PF13304//PF00910//PF03969//PF06414//PF03193//PF00005 Manganese-stabilising protein / photosystem II polypeptide//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//RNA helicase//AFG1-like ATPase//Zeta toxin//Protein of unknown function, DUF258//ABC transporter GO:0042549//GO:0015979//GO:0006200 photosystem II stabilization//photosynthesis//obsolete ATP catabolic process GO:0016301//GO:0016887//GO:0005525//GO:0005509//GO:0003724//GO:0005524//GO:0003723//GO:0003924 kinase activity//ATPase activity//GTP binding//calcium ion binding//RNA helicase activity//ATP binding//RNA binding//GTPase activity GO:0009654//GO:0009523//GO:0019898 photosystem II oxygen evolving complex//photosystem II//extrinsic component of membrane KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.36562 BP_3 266.92 4.33 3261 546676387 ERL87409.1 794 1.8e-81 hypothetical protein D910_04804 [Dendroctonus ponderosae] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 594 1.2e-59 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF02558//PF02826//PF02882//PF12242//PF00106//PF08720//PF01370 Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//Influenza C hemagglutinin stalk//NAD dependent epimerase/dehydratase family GO:0009396//GO:0046487//GO:0015940//GO:0007165//GO:0055114//GO:0019064//GO:0008152 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//pantothenate biosynthetic process//signal transduction//oxidation-reduction process//fusion of virus membrane with host plasma membrane//metabolic process GO:0004488//GO:0050662//GO:0016491//GO:0051287//GO:0003824//GO:0046789//GO:0008677 methylenetetrahydrofolate dehydrogenase (NADP+) activity//coenzyme binding//oxidoreductase activity//NAD binding//catalytic activity//host cell surface receptor binding//2-dehydropantoate 2-reductase activity GO:0019031//GO:0009986 viral envelope//cell surface KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.36563 BP_3 2884.20 53.32 2899 332373528 AEE61905.1 891 9.1e-93 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06072 Alphaherpesvirus tegument protein US9 -- -- -- -- GO:0019033 viral tegument -- -- Cluster-8309.36564 BP_3 3237.77 68.47 2571 642934860 XP_971174.2 3111 0.0e+00 PREDICTED: NADPH--cytochrome P450 reductase isoform X1 [Tribolium castaneum] 198472181 XM_001355830.2 178 1.30529e-85 Drosophila pseudoobscura pseudoobscura GA11069 (Dpse\GA11069), partial mRNA K00327 POR NADPH-ferrihemoprotein reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00327 Q27597 2572 3.9e-289 NADPH--cytochrome P450 reductase OS=Drosophila melanogaster GN=Cpr PE=2 SV=2 PF00667//PF00258//PF00175 FAD binding domain//Flavodoxin//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.36565 BP_3 542.26 5.61 4947 91082253 XP_973026.1 3234 0.0e+00 PREDICTED: elongation factor G, mitochondrial [Tribolium castaneum] 170040110 XM_001847803.1 291 3.85688e-148 Culex quinquefasciatus elongation factor G 1, mitochondrial, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 B4HY41 3037 0.0e+00 Elongation factor G, mitochondrial OS=Drosophila sechellia GN=ico PE=3 SV=1 PF03764//PF10461//PF00922//PF04548//PF03144//PF05485//PF01926 Elongation factor G, domain IV//Peptidase S68//Vesiculovirus phosphoprotein//AIG1 family//Elongation factor Tu domain 2//THAP domain//50S ribosome-binding GTPase GO:0006974//GO:0006144//GO:0006915 cellular response to DNA damage stimulus//purine nucleobase metabolic process//apoptotic process GO:0003968//GO:0005525//GO:0003676 RNA-directed RNA polymerase activity//GTP binding//nucleic acid binding GO:0031379 RNA-directed RNA polymerase complex KOG0465 Mitochondrial elongation factor Cluster-8309.36566 BP_3 42.78 0.40 5481 642936846 XP_008197874.1 3578 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase listerin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1C231 1009 1.5e-107 E3 ubiquitin-protein ligase listerin OS=Gallus gallus GN=LTN1 PE=3 SV=1 PF07022//PF00130//PF00097//PF00628//PF05225//PF16866//PF12678//PF12906//PF13639//PF12861 Bacteriophage CI repressor helix-turn-helix domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C3HC4 type (RING finger)//PHD-finger//helix-turn-helix, Psq domain//PHD-finger//RING-H2 zinc finger//RING-variant domain//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0045892//GO:0035556//GO:0016567 negative regulation of transcription, DNA-templated//intracellular signal transduction//protein ubiquitination GO:0008270//GO:0046872//GO:0003677//GO:0005515//GO:0004842 zinc ion binding//metal ion binding//DNA binding//protein binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0803 Predicted E3 ubiquitin ligase Cluster-8309.36568 BP_3 19.00 0.46 2269 642917912 XP_008191379.1 997 3.6e-105 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 504 2.2e-49 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.36569 BP_3 629.86 8.38 3915 91082211 XP_972371.1 1201 1.4e-128 PREDICTED: caspase-8 [Tribolium castaneum]>gi|270008200|gb|EFA04648.1| death related ced-3/Nedd2-like protein [Tribolium castaneum] -- -- -- -- -- K15275 SLC35B1 solute carrier family 35 (UDP-galactose transporter), member B1 http://www.genome.jp/dbget-bin/www_bget?ko:K15275 Q9VDD7 776 1.1e-80 Solute carrier family 35 member B1 homolog OS=Drosophila melanogaster GN=meigo PE=2 SV=1 PF00892//PF00656//PF08449 EamA-like transporter family//Caspase domain//UAA transporter family GO:0055085//GO:0006508 transmembrane transport//proteolysis GO:0004197 cysteine-type endopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1581 UDP-galactose transporter related protein Cluster-8309.36570 BP_3 119.42 2.53 2565 270014632 EFA11080.1 1673 1.7e-183 hypothetical protein TcasGA2_TC004676 [Tribolium castaneum] -- -- -- -- -- K05768 GSN gelsolin http://www.genome.jp/dbget-bin/www_bget?ko:K05768 Q07171 1086 8.1e-117 Gelsolin OS=Drosophila melanogaster GN=Gel PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0443 Actin regulatory proteins (gelsolin/villin family) Cluster-8309.36571 BP_3 1146.00 29.87 2141 646710816 KDR16234.1 415 1.1e-37 Alpha-actinin, sarcomeric [Zootermopsis nevadensis] 719734445 XM_010224358.1 41 1.55918e-09 PREDICTED: Tinamus guttatus actinin, alpha 1 (ACTN1), transcript variant X5, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q7PKQ5 408 2.8e-38 Alpha-actinin, sarcomeric OS=Anopheles gambiae GN=Actn PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36573 BP_3 7.00 0.33 1320 758213798 AJO62212.1 376 2.2e-33 chemosensory protein CSP6 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q9W1C9 294 2.9e-25 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01348//PF03283//PF05388 Type II intron maturase//Pectinacetylesterase//Carboxypeptidase Y pro-peptide GO:0006397 mRNA processing GO:0004185//GO:0016787 serine-type carboxypeptidase activity//hydrolase activity GO:0005773 vacuole -- -- Cluster-8309.36575 BP_3 347.00 55.51 593 478259433 ENN79323.1 479 1.1e-45 hypothetical protein YQE_04232, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6UXI9 138 1.6e-07 Nephronectin OS=Homo sapiens GN=NPNT PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36576 BP_3 3933.80 105.73 2085 91085965 XP_971530.1 2068 2.2e-229 PREDICTED: protein ERGIC-53 [Tribolium castaneum]>gi|270010174|gb|EFA06622.1| hypothetical protein TcasGA2_TC009540 [Tribolium castaneum] -- -- -- -- -- K10080 LMAN1, ERGIC53 lectin, mannose-binding 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10080 Q9D0F3 1075 1.2e-115 Protein ERGIC-53 OS=Mus musculus GN=Lman1 PE=2 SV=1 PF08649//PF06320//PF00139//PF03388 DASH complex subunit Dad1//GCN5-like protein 1 (GCN5L1)//Legume lectin domain//Legume-like lectin family GO:0030472 mitotic spindle organization in nucleus GO:0030246 carbohydrate binding GO:0016020//GO:0072686//GO:0042729//GO:0031083 membrane//mitotic spindle//DASH complex//BLOC-1 complex KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.36577 BP_3 4232.30 328.88 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36578 BP_3 803.78 5.00 8045 546681997 ERL91993.1 4107 0.0e+00 hypothetical protein D910_09315 [Dendroctonus ponderosae] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 2242 2.3e-250 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF06701//PF05456//PF09026 Mib_herc2//Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Centromere protein B dimerisation domain GO:0006355//GO:0016567//GO:0045947 regulation of transcription, DNA-templated//protein ubiquitination//negative regulation of translational initiation GO:0003682//GO:0008190//GO:0046872//GO:0004842//GO:0003677 chromatin binding//eukaryotic initiation factor 4E binding//metal ion binding//ubiquitin-protein transferase activity//DNA binding GO:0000775//GO:0000785//GO:0005634 chromosome, centromeric region//chromatin//nucleus KOG4276 Predicted hormone receptor interactor Cluster-8309.36579 BP_3 1932.00 72.79 1571 91086255 XP_966955.1 353 1.2e-30 PREDICTED: eukaryotic translation initiation factor 3 subunit J [Tribolium castaneum]>gi|270010259|gb|EFA06707.1| hypothetical protein TcasGA2_TC009638 [Tribolium castaneum] -- -- -- -- -- K03245 EIF3J translation initiation factor 3 subunit J http://www.genome.jp/dbget-bin/www_bget?ko:K03245 Q0ZB73 196 7.9e-14 Eukaryotic translation initiation factor 3 subunit J OS=Bombyx mori PE=2 SV=1 PF02724//PF01080//PF03176//PF08597 CDC45-like protein//Presenilin//MMPL family//Translation initiation factor eIF3 subunit GO:0006446//GO:0006270 regulation of translational initiation//DNA replication initiation GO:0004190//GO:0003743 aspartic-type endopeptidase activity//translation initiation factor activity GO:0016021//GO:0005840//GO:0016020//GO:0005852//GO:0005737 integral component of membrane//ribosome//membrane//eukaryotic translation initiation factor 3 complex//cytoplasm -- -- Cluster-8309.36580 BP_3 487.00 13.24 2065 642911105 XP_008200579.1 3123 0.0e+00 PREDICTED: twitchin isoform X7 [Tribolium castaneum] 462386192 APGK01020323.1 230 1.29542e-114 Dendroctonus ponderosae Seq01020333, whole genome shotgun sequence -- -- -- -- Q23551 1384 1.8e-151 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF05506//PF16794//PF01108//PF16656//PF13895//PF00041 Domain of unknown function (DUF756)//Fibronectin-III type domain//Tissue factor//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0009395//GO:0006771//GO:0016042 hexachlorocyclohexane metabolic process//phospholipid catabolic process//riboflavin metabolic process//lipid catabolic process GO:0005515//GO:0004629//GO:0046872//GO:0003993 protein binding//phospholipase C activity//metal ion binding//acid phosphatase activity -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.36582 BP_3 42.67 0.66 3410 678336953 CDW75723.1 594 2.9e-58 UNKNOWN [Stylonychia lemnae] 375005309 JN619131.1 1775 0 Pogonocherus hispidulus voucher BMNH:835571 18S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM5 140 5.3e-07 Putative uncharacterized protein ART3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART3 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36583 BP_3 6390.86 33.06 9609 642930353 XP_008196361.1 7185 0.0e+00 PREDICTED: protein 4.1 homolog isoform X2 [Tribolium castaneum] 462296961 APGK01052190.1 77 6.88457e-29 Dendroctonus ponderosae Seq01052200, whole genome shotgun sequence K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1372 2.1e-149 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- KOG3527 Erythrocyte membrane protein 4.1 and related proteins of the ERM family Cluster-8309.36585 BP_3 6.75 0.49 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36586 BP_3 5.00 1.29 478 741829289 AJA91071.1 155 3.3e-08 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36590 BP_3 4121.40 39.67 5299 189240885 XP_971484.2 5737 0.0e+00 PREDICTED: splicing factor 3B subunit 1 isoform X1 [Tribolium castaneum] 347963318 XM_310958.5 1205 0 Anopheles gambiae str. PEST AGAP000178-PA (AgaP_AGAP000178) mRNA, complete cds K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O75533 4943 0.0e+00 Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 PF07571//PF01264//PF04162//PF04931//PF08064//PF02985 TAF6 C-terminal HEAT repeat domain//Chorismate synthase//Gyrovirus capsid protein (VP1)//DNA polymerase phi//UME (NUC010) domain//HEAT repeat GO:0009069//GO:0006571//GO:0006260//GO:0051090//GO:0016310//GO:0006351//GO:0009073//GO:0000162//GO:0009094 serine family amino acid metabolic process//tyrosine biosynthetic process//DNA replication//regulation of sequence-specific DNA binding transcription factor activity//phosphorylation//transcription, DNA-templated//aromatic amino acid family biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process GO:0004674//GO:0004107//GO:0003887//GO:0005515//GO:0003677 protein serine/threonine kinase activity//chorismate synthase activity//DNA-directed DNA polymerase activity//protein binding//DNA binding GO:0042575//GO:0019028//GO:0005634 DNA polymerase complex//viral capsid//nucleus KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.36591 BP_3 417.61 5.21 4152 194766015 XP_001965120.1 311 2.3e-25 GF23497 [Drosophila ananassae]>gi|190617730|gb|EDV33254.1| GF23497 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36592 BP_3 4790.83 189.08 1513 211939884 ACJ13424.1 872 7.6e-91 serpin [Sphenophorus levis] -- -- -- -- -- -- -- -- -- P80034 579 2.9e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36593 BP_3 256.89 4.35 3137 642912940 XP_008201316.1 860 3.9e-89 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80034 565 2.6e-56 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.36596 BP_3 13033.52 2017.88 603 91091798 XP_970498.1 621 3.8e-62 PREDICTED: 40S ribosomal protein S14 [Tribolium castaneum]>gi|642937302|ref|XP_008198777.1| PREDICTED: 40S ribosomal protein S14 [Tribolium castaneum]>gi|270000834|gb|EEZ97281.1| hypothetical protein TcasGA2_TC011085 [Tribolium castaneum] 620695572 KJ489363.1 220 1.31563e-109 Dastarcus helophoroides ribosomal protein mRNA, complete cds K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 P14130 594 2.1e-60 40S ribosomal protein S14 OS=Drosophila melanogaster GN=RpS14a PE=1 SV=1 PF00411//PF03423 Ribosomal protein S11//Carbohydrate binding domain (family 25) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:2001070 structural constituent of ribosome//starch binding GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-8309.36597 BP_3 51.82 1.13 2503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05309 TraE protein GO:0000746 conjugation -- -- -- -- -- -- Cluster-8309.36598 BP_3 100.01 2.68 2089 91077370 XP_975175.1 898 1.0e-93 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001655|gb|EEZ98102.1| hypothetical protein TcasGA2_TC000515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28493 580 3.1e-58 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.366 BP_3 16.00 2.25 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3660 BP_3 10.00 0.64 1043 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36600 BP_3 8.00 0.57 963 332374140 AEE62211.1 584 1.2e-57 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O76879 195 6.3e-14 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36601 BP_3 2252.03 29.61 3958 91077534 XP_967040.1 779 1.2e-79 PREDICTED: myophilin [Tribolium castaneum]>gi|270001583|gb|EEZ98030.1| hypothetical protein TcasGA2_TC000431 [Tribolium castaneum] 768423547 XM_011554383.1 125 5.85417e-56 PREDICTED: Plutella xylostella muscle-specific protein 20 (LOC105384189), mRNA -- -- -- -- P14318 417 4.7e-39 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain GO:0031032 actomyosin structure organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG2046 Calponin Cluster-8309.36602 BP_3 647.00 17.56 2068 478263346 ENN81724.1 822 6.5e-85 hypothetical protein YQE_01886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF00032 Oxaloacetate decarboxylase, gamma chain//Cytochrome b(C-terminal)/b6/petD GO:0071436//GO:0006090//GO:0006118//GO:0006814//GO:0006560//GO:0006525 sodium ion export//pyruvate metabolic process//obsolete electron transport//sodium ion transport//proline metabolic process//arginine metabolic process GO:0015081//GO:0009055//GO:0016491//GO:0008948 sodium ion transmembrane transporter activity//electron carrier activity//oxidoreductase activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.36603 BP_3 4246.07 54.60 4040 642933525 XP_008197455.1 393 7.1e-35 PREDICTED: protein alan shepard isoform X2 [Tribolium castaneum] 642933533 XM_008199237.1 55 4.88919e-17 PREDICTED: Tribolium castaneum protein alan shepard (LOC663083), transcript variant X7, mRNA -- -- -- -- B4LFQ9 132 5.3e-06 Protein alan shepard OS=Drosophila virilis GN=shep PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36604 BP_3 478.01 16.20 1714 642912323 XP_969456.2 1349 4.2e-146 PREDICTED: aldose reductase [Tribolium castaneum] 523485322 KC007347.1 74 5.62197e-28 Agrotis ipsilon clone Unigene_1274 aldo-keto reductase mRNA, partial cds K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 951 2.4e-101 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.36605 BP_3 183.20 12.57 994 642922790 XP_008193326.1 963 1.4e-101 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 382 1.3e-35 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.36606 BP_3 776.50 6.28 6253 270007317 EFA03765.1 2164 4.8e-240 hypothetical protein TcasGA2_TC013876 [Tribolium castaneum] 642921924 XM_008194725.1 121 1.5521e-53 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4 gamma 3-like (LOC656935), transcript variant X3, mRNA K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 O43432 889 1.4e-93 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens GN=EIF4G3 PE=1 SV=2 PF02020//PF05372//PF02854 eIF4-gamma/eIF5/eIF2-epsilon//Delta lysin family//MIF4G domain GO:0019836 hemolysis by symbiont of host erythrocytes GO:0003723//GO:0005515 RNA binding//protein binding GO:0005576 extracellular region KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.36607 BP_3 95.63 1.05 4697 642928280 XP_008195517.1 1862 3.7e-205 PREDICTED: uncharacterized protein LOC658443 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12737 SDCCAG10 peptidyl-prolyl cis-trans isomerase SDCCAG10 http://www.genome.jp/dbget-bin/www_bget?ko:K12737 Q7ZW86 591 3.7e-59 Peptidyl-prolyl cis-trans isomerase CWC27 homolog OS=Danio rerio GN=cwc27 PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0885 Peptidyl-prolyl cis-trans isomerase Cluster-8309.36609 BP_3 993.00 7.62 6570 546685505 ERL95003.1 1008 5.6e-106 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 173 1.5e-10 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF01442//PF05478//PF00430//PF01544//PF07464//PF17078//PF02601//PF04513 Apolipoprotein A1/A4/E domain//Prominin//ATP synthase B/B' CF(0)//CorA-like Mg2+ transporter protein//Apolipophorin-III precursor (apoLp-III)//SWI5-dependent HO expression protein 3//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0015986//GO:0006308//GO:0042157//GO:0030001//GO:0048309//GO:0051028//GO:0006869//GO:0015992//GO:0055085 ATP synthesis coupled proton transport//DNA catabolic process//lipoprotein metabolic process//metal ion transport//endoplasmic reticulum inheritance//mRNA transport//lipid transport//proton transport//transmembrane transport GO:0046873//GO:0008289//GO:0008855//GO:0015078//GO:0005198 metal ion transmembrane transporter activity//lipid binding//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//structural molecule activity GO:0016020//GO:0005576//GO:0019031//GO:0045263//GO:0009318//GO:0016021//GO:0019028 membrane//extracellular region//viral envelope//proton-transporting ATP synthase complex, coupling factor F(o)//exodeoxyribonuclease VII complex//integral component of membrane//viral capsid -- -- Cluster-8309.36610 BP_3 53.77 0.31 8724 642913944 XP_008201224.1 10684 0.0e+00 PREDICTED: leucine-rich repeat serine/threonine-protein kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TZM3 2932 0.0e+00 Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6 PF07645//PF00023//PF00071//PF07714//PF13606//PF08477//PF00069//PF00025//PF13855 Calcium-binding EGF domain//Ankyrin repeat//Ras family//Protein tyrosine kinase//Ankyrin repeat//Ras of Complex, Roc, domain of DAPkinase//Protein kinase domain//ADP-ribosylation factor family//Leucine rich repeat GO:0006468//GO:0007264 protein phosphorylation//small GTPase mediated signal transduction GO:0004672//GO:0005515//GO:0005509//GO:0005524//GO:0005525 protein kinase activity//protein binding//calcium ion binding//ATP binding//GTP binding -- -- -- -- Cluster-8309.36611 BP_3 173.35 1.30 6698 189237751 XP_001812575.1 3801 0.0e+00 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 9.9e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF00787//PF04769//PF08070 PX domain//Mating-type protein MAT alpha 1 HMG-box//DTHCT (NUC029) region GO:0006265//GO:0045895//GO:0007531 DNA topological change//positive regulation of mating-type specific transcription, DNA-templated//mating type determination GO:0003918//GO:0008301//GO:0003677//GO:0005524//GO:0035091 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding, bending//DNA binding//ATP binding//phosphatidylinositol binding GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.36613 BP_3 1206.97 19.36 3296 546676952 ERL87876.1 1888 2.5e-208 hypothetical protein D910_05264 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 943 4.0e-100 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01700//PF03015//PF01370//PF01073 Orbivirus VP3 (T2) protein//Male sterility protein//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0008209//GO:0055114//GO:0006694//GO:0008207 estrogen metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0005198//GO:0016616//GO:0003824//GO:0050662//GO:0003854//GO:0080019 structural molecule activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.36614 BP_3 624.42 7.35 4385 642937338 XP_008198794.1 897 2.8e-93 PREDICTED: innexin inx7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3W6 575 2.5e-57 Innexin inx7 OS=Drosophila melanogaster GN=Inx7 PE=2 SV=1 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.36615 BP_3 283.23 1.13 12385 91092464 XP_970082.1 4337 0.0e+00 PREDICTED: glycine dehydrogenase (decarboxylating), mitochondrial [Tribolium castaneum]>gi|270004725|gb|EFA01173.1| hypothetical protein TcasGA2_TC010496 [Tribolium castaneum] 332372930 BT126644.1 662 0 Dendroctonus ponderosae clone DPO0411_K02 unknown mRNA K00281 GLDC, gcvP glycine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00281 P23378 3262 0.0e+00 Glycine dehydrogenase (decarboxylating), mitochondrial OS=Homo sapiens GN=GLDC PE=1 SV=2 PF01053//PF01212//PF02347//PF01176//PF00344 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Glycine cleavage system P-protein//Translation initiation factor 1A / IF-1//SecY translocase GO:0015031//GO:0055114//GO:0006566//GO:0006563//GO:0006520//GO:0006546//GO:0006544//GO:0006413//GO:0006446 protein transport//oxidation-reduction process//threonine metabolic process//L-serine metabolic process//cellular amino acid metabolic process//glycine catabolic process//glycine metabolic process//translational initiation//regulation of translational initiation GO:0016829//GO:0003743//GO:0004375//GO:0030170//GO:0003723 lyase activity//translation initiation factor activity//glycine dehydrogenase (decarboxylating) activity//pyridoxal phosphate binding//RNA binding GO:0005840//GO:0016020 ribosome//membrane KOG2040 Glycine dehydrogenase (decarboxylating) Cluster-8309.36616 BP_3 1036.82 3.30 15439 642914058 XP_008201527.1 14432 0.0e+00 PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3114 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00018//PF14604//PF00435//PF00307//PF11616 SH3 domain//Variant SH3 domain//Spectrin repeat//Calponin homology (CH) domain//WD repeat binding protein EZH2 GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36617 BP_3 865.95 14.23 3225 270016078 EFA12526.1 1420 4.6e-154 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT34 769 5.8e-80 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.36618 BP_3 5.00 0.43 856 642923075 XP_008193601.1 825 1.2e-85 PREDICTED: uncharacterized protein LOC655361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76879 216 2.1e-16 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36620 BP_3 351.22 28.44 887 91091864 XP_968949.1 505 1.6e-48 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [Tribolium castaneum]>gi|270001295|gb|EEZ97742.1| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 [Tribolium castaneum] -- -- -- -- -- K03964 NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03964 Q02372 211 8.1e-16 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Bos taurus GN=NDUFB8 PE=1 SV=1 PF04839//PF05821 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)//NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) GO:0006744//GO:0006118//GO:0006814//GO:0015992//GO:0042254//GO:0006120//GO:0006412 ubiquinone biosynthetic process//obsolete electron transport//sodium ion transport//proton transport//ribosome biogenesis//mitochondrial electron transport, NADH to ubiquinone//translation GO:0003735//GO:0008137//GO:0003954 structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity//NADH dehydrogenase activity GO:0005840//GO:0005739 ribosome//mitochondrion -- -- Cluster-8309.36621 BP_3 2695.41 21.00 6478 478250068 ENN70574.1 6277 0.0e+00 hypothetical protein YQE_12749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TDM6 841 5.2e-88 Disks large homolog 5 OS=Homo sapiens GN=DLG5 PE=1 SV=4 PF00595//PF04111//PF06156//PF13180//PF15898 PDZ domain (Also known as DHR or GLGF)//Autophagy protein Apg6//Protein of unknown function (DUF972)//PDZ domain//cGMP-dependent protein kinase interacting domain GO:0006260//GO:0006914 DNA replication//autophagy GO:0019901//GO:0005515 protein kinase binding//protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.36625 BP_3 596.97 11.68 2756 91085939 XP_970530.1 645 2.9e-64 PREDICTED: longitudinals lacking protein-like [Tribolium castaneum]>gi|270010169|gb|EFA06617.1| hypothetical protein TcasGA2_TC009535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KRI2 601 1.5e-60 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36627 BP_3 14.01 152.46 241 350646286 CCD59012.1 147 1.4e-07 saposin containing protein [Schistosoma mansoni] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36628 BP_3 981.83 29.80 1880 531449435 AGT57858.1 1551 1.7e-169 cytochrome P450 6ef1, partial [Leptinotarsa decemlineata] 170072405 XM_001870137.1 44 2.93591e-11 Culex quinquefasciatus cytochrome P450 6a8, mRNA K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 1047 2.0e-112 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.36629 BP_3 2952.27 33.28 4568 642912745 XP_967796.2 1980 7.6e-219 PREDICTED: protein toll [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08953 1239 2.6e-134 Protein toll OS=Drosophila melanogaster GN=Tl PE=1 SV=1 PF13855//PF01582//PF00560//PF13676 Leucine rich repeat//TIR domain//Leucine Rich Repeat//TIR domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.3663 BP_3 1.00 0.36 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36630 BP_3 355.69 1.95 9097 332375166 AEE62724.1 996 1.9e-104 unknown [Dendroctonus ponderosae]>gi|478252403|gb|ENN72829.1| hypothetical protein YQE_10632, partial [Dendroctonus ponderosae]>gi|546680735|gb|ERL90961.1| hypothetical protein D910_08303 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 736 1.1e-75 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF08506//PF10371//PF01118//PF01073//PF13855//PF03015//PF01370//PF03435//PF09107 Cse1//Domain of unknown function//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//Leucine rich repeat//Male sterility protein//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//Elongation factor SelB, winged helix GO:0008210//GO:0006448//GO:0006886//GO:0006694//GO:0055114//GO:0008209//GO:0001514//GO:0008207 estrogen metabolic process//regulation of translational elongation//intracellular protein transport//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//selenocysteine incorporation//C21-steroid hormone metabolic process GO:0051287//GO:0016491//GO:0005515//GO:0003723//GO:0003824//GO:0005525//GO:0003746//GO:0016616//GO:0003854//GO:0050662//GO:0016620//GO:0016903//GO:0080019 NAD binding//oxidoreductase activity//protein binding//RNA binding//catalytic activity//GTP binding//translation elongation factor activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the aldehyde or oxo group of donors//fatty-acyl-CoA reductase (alcohol-forming) activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG1221 Acyl-CoA reductase Cluster-8309.36634 BP_3 11981.69 652.36 1177 755948956 XP_011300956.1 1243 5.6e-134 PREDICTED: 40S ribosomal protein S4 [Fopius arisanus] 264667394 GU120433.1 356 0 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q56FH2 1208 2.6e-131 40S ribosomal protein S4 OS=Lysiphlebus testaceipes GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.36635 BP_3 53.19 0.86 3271 642929336 XP_008195791.1 700 1.4e-70 PREDICTED: AMP deaminase 2 isoform X2 [Tribolium castaneum] 194769475 XM_001966794.1 153 1.31437e-71 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 449 7.5e-43 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00962//PF00465 Adenosine/AMP deaminase//Iron-containing alcohol dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0046872//GO:0019239 oxidoreductase activity//metal ion binding//deaminase activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.36637 BP_3 19759.19 239.39 4270 91081471 XP_967871.1 2277 2.6e-253 PREDICTED: muscle LIM protein Mlp84B isoform X2 [Tribolium castaneum] 674656866 KJ872589.1 597 0 Monochamus alternatus muscle LIM protein mRNA, partial cds -- -- -- -- Q24400 1838 8.5e-204 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36639 BP_3 5052.35 25.45 9860 642915260 XP_008190547.1 1523 1.6e-165 PREDICTED: titin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3664 BP_3 3.00 1.42 392 338714806 XP_003363153.1 202 9.6e-14 PREDICTED: nucleolin-like [Equus caballus] 164697055 AK314106.1 380 0 Homo sapiens cDNA, FLJ94794, highly similar to Homo sapiens prothymosin, alpha (gene sequence 28) (PTMA), mRNA K13784 PTMA prothymosin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13784 -- -- -- -- PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.36641 BP_3 157319.17 4459.69 1992 568253794 ETN62859.1 2234 1.2e-248 Elongation factor 1-alpha 2 [Anopheles darlingi] 727098916 KJ534557.1 786 0 Colaphellus bowringi elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P05303 2201 3.2e-246 Elongation factor 1-alpha 2 OS=Drosophila melanogaster GN=Ef1alpha100E PE=2 SV=2 PF03144//PF02615//PF01926 Elongation factor Tu domain 2//Malate/L-lactate dehydrogenase//50S ribosome-binding GTPase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0005525//GO:0016491 GTP binding//oxidoreductase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.36643 BP_3 242.69 5.25 2521 478250665 ENN71157.1 587 1.4e-57 hypothetical protein YQE_12088, partial [Dendroctonus ponderosae] 194884433 XM_001976222.1 195 4.53742e-95 Drosophila erecta GG22771 (Dere\GG22771), mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 545 4.3e-54 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.36644 BP_3 30800.98 1319.32 1417 357625515 EHJ75936.1 1289 3.1e-139 ribosomal protein P0 [Danaus plexippus] 39651866 AJ534439.1 387 0 Timarcha balearica mRNA for 60S acidic ribosomal protein P0 (rpP0 gene) K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 Q9U3U0 1227 2.0e-133 60S acidic ribosomal protein P0 OS=Ceratitis capitata GN=RpLP0 PE=3 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0815 60S acidic ribosomal protein P0 Cluster-8309.36646 BP_3 180.17 6.97 1537 575503657 AHG97630.1 1798 3.2e-198 cytochrome oxidase subunit I, partial (mitochondrion) [Batocera horsfieldi] 575503656 KF737820.1 1257 0 Batocera horsfieldi voucher HNAU.PP 041 cytochrome oxidase subunit I gene, partial cds; mitochondrial K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00400 1577 5.6e-174 Cytochrome c oxidase subunit 1 OS=Drosophila yakuba GN=mt:CoI PE=3 SV=2 -- -- -- -- -- -- -- -- KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.36648 BP_3 231.56 18.78 886 189236619 XP_001816527.1 890 3.6e-93 PREDICTED: N-alpha-acetyltransferase 20 [Tribolium castaneum]>gi|270005230|gb|EFA01678.1| hypothetical protein TcasGA2_TC007251 [Tribolium castaneum] 572306440 XM_006619049.1 224 1.17726e-111 PREDICTED: Apis dorsata N-alpha-acetyltransferase 20-like (LOC102677987), transcript variant X1, mRNA K17972 NAA20, NAT3 N-terminal acetyltransferase B complex catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17972 Q58ED9 716 2.2e-74 N-alpha-acetyltransferase 20 OS=Danio rerio GN=naa20 PE=2 SV=1 PF00583//PF13508//PF08445//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3234 Acetyltransferase, (GNAT) family Cluster-8309.3665 BP_3 8.00 0.51 1054 149016350 EDL75596.1 197 9.8e-13 rCG23986, isoform CRA_e [Rattus norvegicus] 767918979 XM_011511521.1 792 0 PREDICTED: Homo sapiens prothymosin, alpha (PTMA), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36651 BP_3 418.00 12.77 1869 642915179 XP_008190507.1 362 1.3e-31 PREDICTED: uncharacterized protein LOC659076 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36652 BP_3 317.13 1.43 10963 642920909 XP_008192611.1 9151 0.0e+00 PREDICTED: spectrin beta chain isoform X5 [Tribolium castaneum] 642920908 XM_008194389.1 1970 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7742 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00435//PF01857//PF00307 Spectrin repeat//Retinoblastoma-associated protein B domain//Calponin homology (CH) domain GO:0051726 regulation of cell cycle GO:0005515 protein binding GO:0005634 nucleus KOG0517 Beta-spectrin Cluster-8309.36655 BP_3 7357.31 492.34 1012 373842654 AEY77316.1 564 2.6e-55 extracellular Cu/Zn-superoxide dismutase [Phaedon cochleariae] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 473 3.8e-46 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.36657 BP_3 1014.69 10.93 4767 332375456 AEE62869.1 2175 1.9e-241 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 149 3.2165e-69 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 1823 5.2e-202 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF00224//PF00478//PF03328 Pyruvate kinase, barrel domain//IMP dehydrogenase / GMP reductase domain//HpcH/HpaI aldolase/citrate lyase family GO:0055114//GO:0006094//GO:0015976//GO:0006144//GO:0006096 oxidation-reduction process//gluconeogenesis//carbon utilization//purine nucleobase metabolic process//glycolytic process GO:0000287//GO:0004743//GO:0030955//GO:0003824 magnesium ion binding//pyruvate kinase activity//potassium ion binding//catalytic activity -- -- KOG2323 Pyruvate kinase Cluster-8309.36658 BP_3 1502.00 19.14 4075 478262392 ENN81063.1 5669 0.0e+00 hypothetical protein YQE_02432, partial [Dendroctonus ponderosae] 642911110 XM_008202361.1 1374 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 2089 6.4e-233 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF13895//PF00041//PF06293//PF00069//PF07714 Immunoglobulin domain//Fibronectin type III domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0005515//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein binding//protein kinase activity GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36660 BP_3 1150.00 38.27 1740 674304018 AIL23540.1 539 3.6e-52 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 393 1.2e-36 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36661 BP_3 79.93 0.72 5648 642913457 XP_008201020.1 1887 5.7e-208 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 817221636 XM_012430865.1 450 0 PREDICTED: Orussus abietinus ankyrin repeat domain-containing protein 17 (LOC105702908), mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q9VCA8 1678 4.0e-185 Ankyrin repeat and KH domain-containing protein mask OS=Drosophila melanogaster GN=mask PE=1 SV=2 PF07650//PF00023//PF00013//PF13606//PF07931//PF13014 KH domain//Ankyrin repeat//KH domain//Ankyrin repeat//Chloramphenicol phosphotransferase-like protein//KH domain -- -- GO:0005515//GO:0016740//GO:0005524//GO:0003723 protein binding//transferase activity//ATP binding//RNA binding -- -- -- -- Cluster-8309.36663 BP_3 1793.72 30.10 3164 270003289 EEZ99736.1 3087 0.0e+00 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.04705e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00168//PF00130 C2 domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.36664 BP_3 1282.15 36.37 1991 91094383 XP_971062.1 805 5.8e-83 PREDICTED: alanyl-tRNA editing protein Aarsd1 [Tribolium castaneum]>gi|270014911|gb|EFA11359.1| hypothetical protein TcasGA2_TC011516 [Tribolium castaneum] 332375886 BT128123.1 63 8.53243e-22 Dendroctonus ponderosae clone DPO1131_O04 unknown mRNA K07050 AARSD1, ALAX misacylated tRNA(Ala) deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K07050 Q32LK1 604 4.9e-61 Alanyl-tRNA editing protein Aarsd1 OS=Bos taurus GN=AARSD1 PE=2 SV=1 PF01411//PF01200//PF03367//PF07973//PF01176 tRNA synthetases class II (A)//Ribosomal protein S28e//ZPR1 zinc-finger domain//Threonyl and Alanyl tRNA synthetase second additional domain//Translation initiation factor 1A / IF-1 GO:0042254//GO:0043039//GO:0006522//GO:0006413//GO:0006446//GO:0006412//GO:0006531//GO:0006419 ribosome biogenesis//tRNA aminoacylation//alanine metabolic process//translational initiation//regulation of translational initiation//translation//aspartate metabolic process//alanyl-tRNA aminoacylation GO:0016876//GO:0000166//GO:0008270//GO:0003735//GO:0003743//GO:0005524//GO:0003676//GO:0004813//GO:0003723 ligase activity, forming aminoacyl-tRNA and related compounds//nucleotide binding//zinc ion binding//structural constituent of ribosome//translation initiation factor activity//ATP binding//nucleic acid binding//alanine-tRNA ligase activity//RNA binding GO:0005737//GO:0005622//GO:0005840 cytoplasm//intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-8309.36665 BP_3 41908.18 657.05 3366 613485521 AHX26755.1 646 2.7e-64 ATF4 [Tribolium castaneum] -- -- -- -- -- K04374 ATF4, CREB2 cyclic AMP-dependent transcription factor ATF-4 http://www.genome.jp/dbget-bin/www_bget?ko:K04374 Q9GPH3 194 2.9e-13 Activating transcription factor of chaperone OS=Bombyx mori GN=ATFC PE=2 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.36667 BP_3 623.09 8.58 3792 91093819 XP_968936.1 2345 3.0e-261 PREDICTED: glutamate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270015904|gb|EFA12352.1| hypothetical protein TcasGA2_TC002057 [Tribolium castaneum] 195573296 XM_002104594.1 246 3.056e-123 Drosophila simulans GD18335 (Dsim\GD18335), mRNA K00261 GLUD1_2, gdhA glutamate dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00261 P54385 2045 7.5e-228 Glutamate dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=Gdh PE=1 SV=2 PF02826//PF00208//PF02812 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GO:0055114//GO:0006520//GO:0006118 oxidation-reduction process//cellular amino acid metabolic process//obsolete electron transport GO:0051287//GO:0016639//GO:0016491//GO:0000166 NAD binding//oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor//oxidoreductase activity//nucleotide binding -- -- KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases Cluster-8309.36668 BP_3 273.97 1.37 9924 642930353 XP_008196361.1 7112 0.0e+00 PREDICTED: protein 4.1 homolog isoform X2 [Tribolium castaneum] 462296961 APGK01052190.1 77 7.11113e-29 Dendroctonus ponderosae Seq01052200, whole genome shotgun sequence K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1372 2.1e-149 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 PF07648//PF16954 Kazal-type serine protease inhibitor domain//Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0005515//GO:0015232 protein binding//heme transporter activity -- -- KOG3527 Erythrocyte membrane protein 4.1 and related proteins of the ERM family Cluster-8309.36669 BP_3 67.56 1.45 2535 642913601 XP_008201081.1 459 9.8e-43 PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36670 BP_3 268.40 6.78 2201 642913603 XP_008201082.1 304 8.0e-25 PREDICTED: extensin-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36671 BP_3 298.27 3.67 4205 642913457 XP_008201020.1 4046 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.2e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00784//PF00023 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.36673 BP_3 12.71 1.52 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36674 BP_3 127.91 3.34 2139 642939251 XP_008194779.1 688 2.3e-69 PREDICTED: UPF0602 protein C4orf47-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7E2U8 309 8.4e-27 UPF0602 protein C4orf47 OS=Homo sapiens GN=C4orf47 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36675 BP_3 679.39 3.24 10412 91090496 XP_969212.1 1701 3.9e-186 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] 642935356 XM_964189.2 200 3.14441e-97 PREDICTED: Tribolium castaneum forkhead box protein P4 (LOC657747), mRNA K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 1044 2.4e-111 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF01299//PF00250//PF01546//PF04277 Lysosome-associated membrane glycoprotein (Lamp)//Forkhead domain//Peptidase family M20/M25/M40//Oxaloacetate decarboxylase, gamma chain GO:0006560//GO:0008152//GO:0006520//GO:0006508//GO:0000051//GO:0006525//GO:0006814//GO:0006355//GO:0006090//GO:0071436 proline metabolic process//metabolic process//cellular amino acid metabolic process//proteolysis//obsolete urea cycle intermediate metabolic process//arginine metabolic process//sodium ion transport//regulation of transcription, DNA-templated//pyruvate metabolic process//sodium ion export GO:0004046//GO:0015081//GO:0008237//GO:0008948//GO:0016787//GO:0003700//GO:0043565 aminoacylase activity//sodium ion transmembrane transporter activity//metallopeptidase activity//oxaloacetate decarboxylase activity//hydrolase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0016020//GO:0005737 transcription factor complex//membrane//cytoplasm KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.36676 BP_3 847.79 5.40 7863 642937519 XP_008199079.1 802 5.1e-82 PREDICTED: heterogeneous nuclear ribonucleoprotein 27C isoform X3 [Tribolium castaneum] 642937522 XM_008200859.1 133 4.17047e-60 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X5, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 P48809 573 7.6e-57 Heterogeneous nuclear ribonucleoprotein 27C OS=Drosophila melanogaster GN=Hrb27C PE=1 SV=2 PF00076//PF08085 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Entericidin EcnA/B family GO:0009636 response to toxic substance GO:0003676 nucleic acid binding GO:0016020 membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.36678 BP_3 1248.46 42.46 1709 91079995 XP_970906.1 932 9.4e-98 PREDICTED: FK506-binding protein 2 isoform X2 [Tribolium castaneum]>gi|270003237|gb|EEZ99684.1| hypothetical protein TcasGA2_TC002441 [Tribolium castaneum] -- -- -- -- -- K09577 FKBP14 FK506-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09577 Q9NWM8 413 5.9e-39 Peptidyl-prolyl cis-trans isomerase FKBP14 OS=Homo sapiens GN=FKBP14 PE=1 SV=1 PF13405//PF10591//PF13833//PF00036//PF13499//PF00254//PF13202 EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain pair//FKBP-type peptidyl-prolyl cis-trans isomerase//EF hand GO:0006457//GO:0007165 protein folding//signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0549 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.36679 BP_3 1323.71 45.83 1684 91079995 XP_970906.1 932 9.3e-98 PREDICTED: FK506-binding protein 2 isoform X2 [Tribolium castaneum]>gi|270003237|gb|EEZ99684.1| hypothetical protein TcasGA2_TC002441 [Tribolium castaneum] -- -- -- -- -- K09577 FKBP14 FK506-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09577 Q9NWM8 413 5.8e-39 Peptidyl-prolyl cis-trans isomerase FKBP14 OS=Homo sapiens GN=FKBP14 PE=1 SV=1 PF13499//PF13833//PF10591//PF13405//PF00036//PF00254//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//FKBP-type peptidyl-prolyl cis-trans isomerase//EF hand GO:0007165//GO:0006457 signal transduction//protein folding GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0549 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.36680 BP_3 594.53 11.28 2833 91081545 XP_974976.1 1293 2.2e-139 PREDICTED: calumenin [Tribolium castaneum]>gi|270006175|gb|EFA02623.1| hypothetical protein TcasGA2_TC008343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDD8 880 6.9e-93 Calumenin OS=Pongo abelii GN=CALU PE=2 SV=1 PF13202//PF13499//PF10591//PF08707//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//Primase C terminal 2 (PriCT-2)//EF-hand domain pair//EF hand//EF-hand domain GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.36681 BP_3 4809.51 58.21 4274 642928729 XP_008199757.1 2652 8.4e-297 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 746860384 XM_011062730.1 215 5.89378e-106 PREDICTED: Acromyrmex echinatior phosphoenolpyruvate carboxykinase [GTP]-like (LOC105149957), transcript variant X4, mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 2332 4.4e-261 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.36683 BP_3 501.91 16.78 1733 91082507 XP_973065.1 1686 3.5e-185 PREDICTED: protein kinase DC2 [Tribolium castaneum]>gi|270007546|gb|EFA03994.1| hypothetical protein TcasGA2_TC014143 [Tribolium castaneum] 645007450 XM_008218052.1 132 3.25651e-60 PREDICTED: Nasonia vitripennis protein kinase DC2 (LOC100119822), transcript variant X4, mRNA K19584 PRKX protein kinase X http://www.genome.jp/dbget-bin/www_bget?ko:K19584 P16912 1332 1.6e-145 Protein kinase DC2 OS=Drosophila melanogaster GN=Pka-C3 PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA) Cluster-8309.36685 BP_3 225.25 5.19 2384 91086399 XP_974859.1 2065 5.5e-229 PREDICTED: 26S protease regulatory subunit 4 [Tribolium castaneum]>gi|270010293|gb|EFA06741.1| hypothetical protein TcasGA2_TC009675 [Tribolium castaneum] 829812394 XM_012773957.1 384 0 PREDICTED: Microcebus murinus proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1), mRNA K03062 PSMC1, RPT2 26S proteasome regulatory subunit T2 http://www.genome.jp/dbget-bin/www_bget?ko:K03062 P48601 1995 3.0e-222 26S protease regulatory subunit 4 OS=Drosophila melanogaster GN=Rpt2 PE=1 SV=2 PF00910//PF00931//PF00005//PF07726//PF02562//PF02367//PF00004//PF07724//PF01695//PF07728//PF01057//PF05496//PF00158//PF06068 RNA helicase//NB-ARC domain//ABC transporter//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus GO:0002949//GO:0006310//GO:0030163//GO:0006355//GO:0019079//GO:0006281 tRNA threonylcarbamoyladenosine modification//DNA recombination//protein catabolic process//regulation of transcription, DNA-templated//viral genome replication//DNA repair GO:0009378//GO:0017111//GO:0003724//GO:0003678//GO:0003723//GO:0043531//GO:0016887//GO:0005524//GO:0008134 four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity//DNA helicase activity//RNA binding//ADP binding//ATPase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0005737//GO:0009379 replication fork//transcription factor complex//cytoplasm//Holliday junction helicase complex KOG0726 26S proteasome regulatory complex, ATPase RPT2 Cluster-8309.36686 BP_3 67.79 3.60 1199 332376935 AEE63607.1 581 3.3e-57 unknown [Dendroctonus ponderosae]>gi|478259710|gb|ENN79554.1| hypothetical protein YQE_04016, partial [Dendroctonus ponderosae]>gi|546676265|gb|ERL87311.1| hypothetical protein D910_04706 [Dendroctonus ponderosae] 758206659 XM_011327360.1 36 5.1865e-07 Fusarium graminearum PH-1 aspartate aminotransferase partial mRNA K14454 GOT1 aspartate aminotransferase, cytoplasmic http://www.genome.jp/dbget-bin/www_bget?ko:K14454 P13221 469 1.3e-45 Aspartate aminotransferase, cytoplasmic OS=Rattus norvegicus GN=Got1 PE=1 SV=3 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.36687 BP_3 519.00 8.52 3227 91078686 XP_971015.1 882 1.1e-91 PREDICTED: gamma-glutamyl hydrolase isoform X1 [Tribolium castaneum]>gi|642915849|ref|XP_008196208.1| PREDICTED: gamma-glutamyl hydrolase isoform X1 [Tribolium castaneum]>gi|270003762|gb|EFA00210.1| hypothetical protein TcasGA2_TC003035 [Tribolium castaneum] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 520 4.3e-51 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722 Peptidase C26 GO:0006541 glutamine metabolic process GO:0016787 hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.36692 BP_3 1634.00 199.75 686 91077530 XP_970573.1 159 1.6e-08 PREDICTED: tyrosine-protein phosphatase non-receptor type 23 [Tribolium castaneum]>gi|270001592|gb|EEZ98039.1| hypothetical protein TcasGA2_TC000442 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36694 BP_3 215.96 1.68 6477 642919008 XP_008191694.1 4125 0.0e+00 PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum]>gi|642919010|ref|XP_008191695.1| PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum] 742179525 XM_010889443.1 55 7.86127e-17 PREDICTED: Esox lucius adenylate cyclase 9 (adcy9), transcript variant X2, mRNA K08049 ADCY9 adenylate cyclase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08049 P51830 1008 2.3e-107 Adenylate cyclase type 9 OS=Mus musculus GN=Adcy9 PE=1 SV=1 PF00211//PF07701//PF06327 Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated//Domain of Unknown Function (DUF1053) GO:0009190//GO:0035556//GO:0006171//GO:0006144//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//cAMP biosynthetic process//purine nucleobase metabolic process//GTP metabolic process//cGMP biosynthetic process GO:0016849//GO:0004016//GO:0004383 phosphorus-oxygen lyase activity//adenylate cyclase activity//guanylate cyclase activity GO:0005886 plasma membrane KOG3618 Adenylyl cyclase Cluster-8309.36696 BP_3 2631.42 51.55 2752 91089191 XP_974448.1 2190 2.0e-243 PREDICTED: signal recognition particle subunit SRP68 [Tribolium castaneum]>gi|270012460|gb|EFA08908.1| hypothetical protein TcasGA2_TC006613 [Tribolium castaneum] -- -- -- -- -- K03107 SRP68 signal recognition particle subunit SRP68 http://www.genome.jp/dbget-bin/www_bget?ko:K03107 Q9VSS2 1309 1.2e-142 Signal recognition particle subunit SRP68 OS=Drosophila melanogaster GN=Srp68 PE=2 SV=1 PF16969//PF13176 RNA-binding signal recognition particle 68//Tetratricopeptide repeat GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0030942//GO:0005047//GO:0005515 7S RNA binding//endoplasmic reticulum signal peptide binding//signal recognition particle binding//protein binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG2460 Signal recognition particle, subunit Srp68 Cluster-8309.36698 BP_3 108.00 5.11 1310 91079754 XP_970847.1 290 2.0e-23 PREDICTED: peptidoglycan-recognition protein LF [Tribolium castaneum]>gi|270004814|gb|EFA01262.1| hypothetical protein TcasGA2_TC002546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75594 209 2.0e-15 Peptidoglycan recognition protein 1 OS=Homo sapiens GN=PGLYRP1 PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009252//GO:0006807//GO:0009253 peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.36699 BP_3 430.00 15.71 1611 332375546 AEE62914.1 865 5.2e-90 unknown [Dendroctonus ponderosae]>gi|478250118|gb|ENN70624.1| hypothetical protein YQE_12798, partial [Dendroctonus ponderosae]>gi|546674473|gb|ERL85838.1| hypothetical protein D910_03253 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W0H3 526 4.4e-52 Lipid droplet-associated hydrolase OS=Drosophila melanogaster GN=CG9186 PE=2 SV=1 PF06821//PF02450 Serine hydrolase//Lecithin:cholesterol acyltransferase GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0016787//GO:0008374 hydrolase activity//O-acyltransferase activity -- -- KOG3975 Uncharacterized conserved protein Cluster-8309.36701 BP_3 268.32 112.00 406 529172383 BAN67667.1 141 1.2e-06 riptocin [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q27905 141 4.8e-08 Probable antibacterial peptide polyprotein OS=Riptortus clavatus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36704 BP_3 5688.96 92.44 3258 642933304 XP_008197362.1 2123 1.4e-235 PREDICTED: eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [Tribolium castaneum] -- -- -- -- -- K03267 ERF3, GSPT peptide chain release factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03267 P15170 1687 2.1e-186 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens GN=GSPT1 PE=1 SV=1 PF00503//PF03144//PF01926 G-protein alpha subunit//Elongation factor Tu domain 2//50S ribosome-binding GTPase GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0004871//GO:0019001//GO:0031683//GO:0005525 GTPase activity//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTP binding -- -- KOG0459 Polypeptide release factor 3 Cluster-8309.36705 BP_3 3292.95 229.27 984 646703952 KDR12362.1 665 4.9e-67 Superoxide dismutase [Cu-Zn] [Zootermopsis nevadensis] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P41973 606 1.4e-61 Superoxide dismutase [Cu-Zn] OS=Drosophila willistoni GN=Sod PE=3 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.36706 BP_3 373.32 3.47 5481 270007804 EFA04252.1 2632 2.3e-294 hypothetical protein TcasGA2_TC014542 [Tribolium castaneum] 831223259 XM_012804206.1 235 5.77155e-117 PREDICTED: Otolemur garnettii RAN binding protein 9 (RANBP9), mRNA -- -- -- -- Q96S59 1739 3.3e-192 Ran-binding protein 9 OS=Homo sapiens GN=RANBP9 PE=1 SV=1 PF06005//PF00622//PF17122//PF04977//PF08513//PF07989 Protein of unknown function (DUF904)//SPRY domain//Zinc-finger//Septum formation initiator//LisH//Centrosomin N-terminal motif 1 GO:0043093//GO:0000917//GO:0007049 FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005737//GO:0005815 cytoplasm//microtubule organizing center KOG1477 SPRY domain-containing proteins Cluster-8309.36707 BP_3 687.43 21.84 1809 91090714 XP_975034.1 589 5.9e-58 PREDICTED: 27 kDa hemolymph protein [Tribolium castaneum]>gi|270013294|gb|EFA09742.1| hypothetical protein TcasGA2_TC011877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q25513 285 4.3e-24 27 kDa hemolymph glycoprotein OS=Manduca sexta PE=1 SV=1 PF03688 Nepovirus coat protein, C-terminal domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.36708 BP_3 171.00 4.28 2219 642930886 XP_008196126.1 427 4.4e-39 PREDICTED: myb-like protein X isoform X6 [Tribolium castaneum] 642930891 XM_008197907.1 97 1.19801e-40 PREDICTED: Tribolium castaneum protein-methionine sulfoxide oxidase MICAL3 (LOC658955), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36710 BP_3 116.40 3.88 1738 478252870 ENN73259.1 802 1.1e-82 hypothetical protein YQE_10155, partial [Dendroctonus ponderosae]>gi|546674747|gb|ERL86052.1| hypothetical protein D910_03466 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U145 311 4.0e-27 Transmembrane protein 64 OS=Mus musculus GN=Tmem64 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36711 BP_3 970264.00 47130.63 1284 133916482 CAM36311.1 154 1.2e-07 hypothetical protein [Thermobia domestica] 359294281 JN986793.1 1072 0 Batocera lineolata mitochondrion, complete genome -- -- -- -- -- -- -- -- PF02459 Adenoviral DNA terminal protein GO:0006260 DNA replication GO:0003677 DNA binding -- -- -- -- Cluster-8309.36712 BP_3 1861.30 7.05 13021 91092056 XP_970271.1 4135 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] 157125487 XM_001654304.1 70 7.27045e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 3356 0.0e+00 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF04218//PF01704//PF07992//PF01593//PF06574//PF01207//PF01884//PF05946//PF04545//PF05225//PF02796//PF03184//PF01180//PF00196//PF00070 CENP-B N-terminal DNA-binding domain//UTP--glucose-1-phosphate uridylyltransferase//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD synthetase//Dihydrouridine synthase (Dus)//PcrB family//Toxin-coregulated pilus subunit TcpA//Sigma-70, region 4//helix-turn-helix, Psq domain//Helix-turn-helix domain of resolvase//DDE superfamily endonuclease//Dihydroorotate dehydrogenase//Bacterial regulatory proteins, luxR family//Pyridine nucleotide-disulphide oxidoreductase GO:0006771//GO:0006310//GO:0009231//GO:0008152//GO:0055114//GO:0006118//GO:0006352//GO:0006206//GO:0006222//GO:0008033//GO:0006355//GO:0006207//GO:0009405 riboflavin metabolic process//DNA recombination//riboflavin biosynthetic process//metabolic process//oxidation-reduction process//obsolete electron transport//DNA-templated transcription, initiation//pyrimidine nucleobase metabolic process//UMP biosynthetic process//tRNA processing//regulation of transcription, DNA-templated//'de novo' pyrimidine nucleobase biosynthetic process//pathogenesis GO:0016987//GO:0003676//GO:0016491//GO:0003700//GO:0016765//GO:0070569//GO:0050660//GO:0009055//GO:0017150//GO:0003677//GO:0004158//GO:0003919//GO:0016627//GO:0051536//GO:0000150 sigma factor activity//nucleic acid binding//oxidoreductase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring alkyl or aryl (other than methyl) groups//uridylyltransferase activity//flavin adenine dinucleotide binding//electron carrier activity//tRNA dihydrouridine synthase activity//DNA binding//dihydroorotate oxidase activity//FMN adenylyltransferase activity//oxidoreductase activity, acting on the CH-CH group of donors//iron-sulfur cluster binding//recombinase activity GO:0005667//GO:0043230//GO:0005737//GO:0009289 transcription factor complex//extracellular organelle//cytoplasm//pilus KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.36717 BP_3 670.22 11.12 3196 751457144 XP_011183174.1 1662 4.0e-182 PREDICTED: protein will die slowly [Bactrocera cucurbitae] 585715269 XM_006825240.1 164 9.85517e-78 PREDICTED: Saccoglossus kowalevskii protein will die slowly-like (LOC100375790), mRNA K14963 WDR5, SWD3, CPS30 COMPASS component SWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K14963 Q9V3J8 1615 4.6e-178 Protein will die slowly OS=Drosophila melanogaster GN=wds PE=1 SV=1 PF07569//PF02944//PF00400 TUP1-like enhancer of split//BESS motif//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus KOG0266 WD40 repeat-containing protein Cluster-8309.36718 BP_3 196.00 2.84 3621 167444216 ABZ80669.1 216 2.1e-14 luxuriosin-like protein [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.36720 BP_3 635.64 14.12 2461 242015216 XP_002428268.1 1387 2.4e-150 cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis]>gi|212512842|gb|EEB15530.1| cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis] 558203653 XM_006132037.1 59 1.77085e-19 PREDICTED: Pelodiscus sinensis mitogen-activated protein kinase kinase 7 (MAP2K7), partial mRNA K04432 MAP2K3, MKK3 mitogen-activated protein kinase kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04432 O09110 1122 5.2e-121 Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus GN=Map2k3 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 Cluster-8309.36721 BP_3 7.00 0.40 1131 332376312 AEE63296.1 390 4.4e-35 unknown [Dendroctonus ponderosae] 332376311 BT128338.1 35 1.75858e-06 Dendroctonus ponderosae clone DPO1410_H07 unknown mRNA -- -- -- -- P02511 131 1.9e-06 Alpha-crystallin B chain OS=Homo sapiens GN=CRYAB PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.36723 BP_3 477.32 10.39 2506 637366323 XP_008121191.1 644 3.4e-64 PREDICTED: oocyte zinc finger protein XlCOF6-like, partial [Anolis carolinensis] 195570403 XM_002103161.1 88 1.36506e-35 Drosophila simulans GD19093 (Dsim\GD19093), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 590 2.6e-59 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF13912//PF11615//PF07776//PF16622//PF00096//PF13465 C2H2-type zinc finger//Protein of unknown function (DUF3249)//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain GO:0000266 mitochondrial fission GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005739//GO:0005634 mitochondrion//nucleus -- -- Cluster-8309.36724 BP_3 1063.10 11.38 4793 270008506 EFA04954.1 2027 2.8e-224 hypothetical protein TcasGA2_TC015023 [Tribolium castaneum] 817187826 XM_012433045.1 176 3.16626e-84 PREDICTED: Orussus abietinus cytospin-A (LOC105704102), transcript variant X5, mRNA -- -- -- -- Q69YQ0 545 8.2e-54 Cytospin-A OS=Homo sapiens GN=SPECC1L PE=1 SV=2 PF09730//PF13851//PF00307//PF00769//PF03920 Microtubule-associated protein Bicaudal-D//Growth-arrest specific micro-tubule binding//Calponin homology (CH) domain//Ezrin/radixin/moesin family//Groucho/TLE N-terminal Q-rich domain GO:0006810//GO:0048870 transport//cell motility GO:0008092//GO:0005515 cytoskeletal protein binding//protein binding GO:0005737//GO:0031514//GO:0019898//GO:0005794 cytoplasm//motile cilium//extrinsic component of membrane//Golgi apparatus KOG4678 FOG: Calponin homology domain Cluster-8309.36725 BP_3 56.43 0.48 5948 752876259 XP_011255518.1 494 2.0e-46 PREDICTED: 60S ribosomal protein L44 [Camponotus floridanus] 642918893 XM_968530.2 160 3.08531e-75 PREDICTED: Tribolium castaneum 60S ribosomal protein L44 (LOC662436), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q9NB33 450 1.0e-42 60S ribosomal protein L44 OS=Ochlerotatus triseriatus GN=RpL44 PE=3 SV=3 PF02150//PF10152//PF00935 RNA polymerases M/15 Kd subunit//Predicted coiled-coil domain-containing protein (DUF2360)//Ribosomal protein L44 GO:0006206//GO:0042254//GO:0006351//GO:0006412//GO:0006144 pyrimidine nucleobase metabolic process//ribosome biogenesis//transcription, DNA-templated//translation//purine nucleobase metabolic process GO:0003735//GO:0003677//GO:0003899 structural constituent of ribosome//DNA binding//DNA-directed RNA polymerase activity GO:0005622//GO:0005840//GO:0005730//GO:0071203 intracellular//ribosome//nucleolus//WASH complex KOG3464 60S ribosomal protein L44 Cluster-8309.36728 BP_3 823.35 11.35 3789 478257467 ENN77623.1 2412 5.1e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 759061923 XM_011342000.1 74 1.25626e-27 PREDICTED: Cerapachys biroi phosphoglucomutase (LOC105281053), transcript variant X2, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 1.7e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF02880//PF00408//PF02879//PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0071704//GO:0005975 organic substance metabolic process//carbohydrate metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG0625 Phosphoglucomutase Cluster-8309.36729 BP_3 44.88 0.48 4770 642924642 XP_008194376.1 4300 0.0e+00 PREDICTED: tensin isoform X2 [Tribolium castaneum] 642924641 XM_008196154.1 177 8.76083e-85 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X2, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 768 1.1e-79 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.36730 BP_3 618.97 3.51 8799 91084843 XP_966905.1 1396 7.6e-151 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] 827549413 XM_004927289.2 82 1.04711e-31 PREDICTED: Bombyx mori Kv channel-interacting protein 1 (LOC101740782), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 844 3.2e-88 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF00404//PF01370//PF13499//PF13833//PF10591//PF13405//PF13202//PF01118//PF01073//PF00036 Male sterility protein//Dockerin type I repeat//NAD dependent epimerase/dehydratase family//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//EF hand GO:0008210//GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0005975//GO:0007165 estrogen metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//carbohydrate metabolic process//signal transduction GO:0005509//GO:0003824//GO:0051287//GO:0080019//GO:0016620//GO:0003854//GO:0050662//GO:0004553//GO:0016616 calcium ion binding//catalytic activity//NAD binding//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//hydrolase activity, hydrolyzing O-glycosyl compounds//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.36731 BP_3 296.00 10.69 1626 91091362 XP_972603.1 648 7.6e-65 PREDICTED: uncharacterized protein LOC661347 [Tribolium castaneum]>gi|270014346|gb|EFA10794.1| hypothetical protein TcasGA2_TC012859 [Tribolium castaneum] -- -- -- -- -- K03962 NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03962 -- -- -- -- PF06479 Ribonuclease 2-5A GO:0051252//GO:0006397 regulation of RNA metabolic process//mRNA processing GO:0004540 ribonuclease activity -- -- -- -- Cluster-8309.36732 BP_3 38.22 0.69 2967 642932670 XP_008196939.1 401 6.1e-36 PREDICTED: BAG domain-containing protein Samui isoform X2 [Tribolium castaneum] -- -- -- -- -- K09558 BAG4 BCL2-associated athanogene 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09558 Q9BLJ6 306 2.6e-26 BAG domain-containing protein Samui OS=Bombyx mori GN=Samui PE=2 SV=1 PF09198//PF02179 Bacteriophage T4 beta-glucosyltransferase//BAG domain GO:0006304 DNA modification GO:0033821//GO:0051087 DNA beta-glucosyltransferase activity//chaperone binding -- -- KOG4361 BCL2-associated athanogene-like proteins and related BAG family chaperone regulators Cluster-8309.36735 BP_3 131.06 0.55 11731 642913459 XP_008201021.1 2154 1.3e-238 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] 642913458 XM_008202799.1 192 9.92406e-93 PREDICTED: Tribolium castaneum uncharacterized LOC103315067 (LOC103315067), mRNA K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q9VAN0 507 5.1e-49 Probable phosphoserine aminotransferase OS=Drosophila melanogaster GN=CG11899 PE=2 SV=1 PF03169//PF05206 OPT oligopeptide transporter protein//Methyltransferase TRM13 GO:0055085//GO:0008033 transmembrane transport//tRNA processing GO:0008168 methyltransferase activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.36736 BP_3 161.63 1.07 7582 642920861 XP_008192589.1 3615 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 586 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3121 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF16656//PF07353//PF02480//PF07354//PF00041//PF13895 Tissue factor//Purple acid Phosphatase, N-terminal domain//Uroplakin II//Alphaherpesvirus glycoprotein E//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Immunoglobulin domain GO:0006771//GO:0061024//GO:0019497//GO:0007339 riboflavin metabolic process//membrane organization//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020//GO:0005576//GO:0030176 membrane//extracellular region//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.36739 BP_3 755.00 12.69 3159 642934001 XP_973480.2 2866 0.0e+00 PREDICTED: wolframin isoform X1 [Tribolium castaneum] -- -- -- -- -- K14020 WFS1 wolfamin http://www.genome.jp/dbget-bin/www_bget?ko:K14020 P56695 526 8.6e-52 Wolframin OS=Mus musculus GN=Wfs1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36740 BP_3 20.38 0.95 1323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36741 BP_3 33965.46 128.29 13053 642920090 XP_008192200.1 2152 2.5e-238 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920089 XM_008193978.1 390 0 PREDICTED: Tribolium castaneum histone acetyltransferase Tip60 (LOC664310), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q5RBG4 1541 7.1e-169 Histone acetyltransferase KAT5 OS=Pongo abelii GN=KAT5 PE=2 SV=1 PF03719//PF13855//PF00560//PF01853//PF00333//PF05261//PF13508//PF00583 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//Leucine Rich Repeat//MOZ/SAS family//Ribosomal protein S5, N-terminal domain//TraM protein, DNA-binding//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0006355//GO:0042254//GO:0000746//GO:0042967//GO:0006412 regulation of transcription, DNA-templated//ribosome biogenesis//conjugation//acyl-carrier-protein biosynthetic process//translation GO:0003735//GO:0016747//GO:0003723//GO:0003677//GO:0008080//GO:0005515 structural constituent of ribosome//transferase activity, transferring acyl groups other than amino-acyl groups//RNA binding//DNA binding//N-acetyltransferase activity//protein binding GO:0005840//GO:0005634 ribosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.36742 BP_3 1920.61 103.06 1190 91088745 XP_975314.1 418 2.6e-38 PREDICTED: uncharacterized protein LOC664209 [Tribolium castaneum]>gi|270012304|gb|EFA08752.1| hypothetical protein TcasGA2_TC006429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284//PF00335 Membrane-associating domain//Tetraspanin family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.36743 BP_3 1092.73 17.45 3310 307173098 EFN64217.1 811 2.0e-83 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 428 2.1e-40 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF04977//PF05485//PF00619//PF13851 Septum formation initiator//THAP domain//Caspase recruitment domain//Growth-arrest specific micro-tubule binding GO:0007049//GO:0042981//GO:0048870 cell cycle//regulation of apoptotic process//cell motility GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.36745 BP_3 299.43 2.40 6295 546683632 ERL93420.1 2078 4.5e-230 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 Q9PTP2 475 1.4e-45 Axin-related protein OS=Xenopus laevis PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36746 BP_3 283.00 1.65 8579 642921903 XP_008192938.1 883 2.3e-91 PREDICTED: uncharacterized protein LOC103312895 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF02892//PF08587//PF13465//PF00096 C2H2-type zinc finger//BED zinc finger//Ubiquitin associated domain (UBA)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0003677//GO:0004674//GO:0046872 DNA binding//protein serine/threonine kinase activity//metal ion binding -- -- -- -- Cluster-8309.36749 BP_3 171.76 2.56 3524 270011248 EFA07696.1 495 9.1e-47 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53814 298 2.6e-25 Smoothelin OS=Homo sapiens GN=SMTN PE=1 SV=7 -- -- -- -- -- -- -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.36750 BP_3 19.01 0.55 1970 91079780 XP_976161.1 278 7.4e-22 PREDICTED: uncharacterized protein LOC656005 [Tribolium castaneum]>gi|270003312|gb|EEZ99759.1| hypothetical protein TcasGA2_TC002531 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00356 Bacterial regulatory proteins, lacI family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.36751 BP_3 1957.15 66.00 1721 642912485 XP_008200884.1 2209 7.9e-246 PREDICTED: protein hu-li tai shao isoform X2 [Tribolium castaneum] 752873776 XM_011255881.1 75 1.56963e-28 PREDICTED: Camponotus floridanus protein hu-li tai shao (LOC105250025), transcript variant X7, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1509 4.8e-166 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36752 BP_3 168.95 0.70 11915 642912485 XP_008200884.1 2111 1.3e-233 PREDICTED: protein hu-li tai shao isoform X2 [Tribolium castaneum] 642912486 XM_008202663.1 75 1.10512e-27 PREDICTED: Tribolium castaneum protein hu-li tai shao (LOC659560), transcript variant X3, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1443 1.5e-157 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36753 BP_3 5263.56 22.46 11587 270002882 EEZ99329.1 2111 1.2e-233 hu li tai shao [Tribolium castaneum] 642912486 XM_008202663.1 133 6.15499e-60 PREDICTED: Tribolium castaneum protein hu-li tai shao (LOC659560), transcript variant X3, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1443 1.5e-157 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36754 BP_3 848.27 2.24 18534 612342210 AHW99830.1 23501 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 2506 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 19805 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00520//PF00487//PF06423//PF06459//PF00622//PF01365//PF13499//PF13833//PF02815 Ion transport protein//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//SPRY domain//RIH domain//EF-hand domain pair//EF-hand domain pair//MIR domain GO:0006874//GO:0006816//GO:0055085//GO:0070588//GO:0006506//GO:0006811//GO:0006629 cellular calcium ion homeostasis//calcium ion transport//transmembrane transport//calcium ion transmembrane transport//GPI anchor biosynthetic process//ion transport//lipid metabolic process GO:0005216//GO:0005509//GO:0005262//GO:0005219//GO:0005515//GO:0016746 ion channel activity//calcium ion binding//calcium channel activity//ryanodine-sensitive calcium-release channel activity//protein binding//transferase activity, transferring acyl groups GO:0005622//GO:0016021//GO:0016020//GO:0005789 intracellular//integral component of membrane//membrane//endoplasmic reticulum membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.36756 BP_3 2562.18 17.47 7360 642930787 XP_008196091.1 3584 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.7e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF07531//PF01428//PF00383//PF02217//PF16711//PF08211//PF08069 NHR1 homology to TAF//AN1-like Zinc finger//Cytidine and deoxycytidylate deaminase zinc-binding region//Origin of replication binding protein//Actin-binding domain of plant-specific actin-binding protein//Cytidine and deoxycytidylate deaminase zinc-binding region//Ribosomal S13/S15 N-terminal domain GO:0006412//GO:0006206//GO:0006807//GO:0009972//GO:0006355//GO:0006260//GO:0042254//GO:0046087 translation//pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//cytidine deamination//regulation of transcription, DNA-templated//DNA replication//ribosome biogenesis//cytidine metabolic process GO:0004126//GO:0003688//GO:0003779//GO:0003735//GO:0008270//GO:0003700 cytidine deaminase activity//DNA replication origin binding//actin binding//structural constituent of ribosome//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0046809//GO:0005840 transcription factor complex//replication compartment//ribosome KOG3183 Predicted Zn-finger protein Cluster-8309.36757 BP_3 4826.84 22.38 10689 642935263 XP_008197938.1 6822 0.0e+00 PREDICTED: hemocytin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98092 5375 0.0e+00 Hemocytin OS=Bombyx mori PE=2 SV=1 PF05375//PF00093//PF11051//PF05805 Pacifastin inhibitor (LCMII)//von Willebrand factor type C domain//Mannosyltransferase putative//L6 membrane protein GO:0006486 protein glycosylation GO:0016757//GO:0030414//GO:0005515 transferase activity, transferring glycosyl groups//peptidase inhibitor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.36759 BP_3 2368.60 22.03 5474 642918013 XP_008198979.1 1042 5.3e-110 PREDICTED: cytochrome c1, heme protein, mitochondrial [Tribolium castaneum]>gi|270004913|gb|EFA01361.1| mitochondrial cytochrome c1 [Tribolium castaneum] -- -- -- -- -- K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 755 4.2e-78 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF02167//PF13442//PF00034 Cytochrome C1 family//Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome c GO:0006118 obsolete electron transport GO:0005488//GO:0009055//GO:0020037 binding//electron carrier activity//heme binding -- -- KOG3052 Cytochrome c1 Cluster-8309.36760 BP_3 345.45 3.15 5573 478262859 ENN81341.1 1820 3.3e-200 hypothetical protein YQE_02252, partial [Dendroctonus ponderosae] 213513283 NM_001141934.1 389 0 Tribolium castaneum estrogen-related receptor (Err), mRNA K08703 NR3BN, ERR estrogen-related receptor ERR http://www.genome.jp/dbget-bin/www_bget?ko:K08703 O95718 803 1.1e-83 Steroid hormone receptor ERR2 OS=Homo sapiens GN=ESRRB PE=1 SV=2 PF00104//PF00106//PF00324//PF00105//PF01370 Ligand-binding domain of nuclear hormone receptor//short chain dehydrogenase//Amino acid permease//Zinc finger, C4 type (two domains)//NAD dependent epimerase/dehydratase family GO:0006355//GO:0043401//GO:0008152//GO:0055085//GO:0006810 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//metabolic process//transmembrane transport//transport GO:0008270//GO:0043565//GO:0003700//GO:0050662//GO:0003824//GO:0016491 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//coenzyme binding//catalytic activity//oxidoreductase activity GO:0016020//GO:0005634//GO:0005667 membrane//nucleus//transcription factor complex -- -- Cluster-8309.36762 BP_3 1560.27 150.33 792 589060796 AHK26791.1 476 3.3e-45 eukaryotic translation initiation factor 4A [Epicauta chinensis] 630969033 XM_007882734.1 83 2.52099e-33 Pseudozyma flocculosa PF-1 hypothetical protein partial mRNA K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 Q3SZ54 433 1.3e-41 Eukaryotic initiation factor 4A-I OS=Bos taurus GN=EIF4A1 PE=2 SV=1 PF00579 tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.36763 BP_3 19392.00 144.97 6739 270007027 EFA03475.1 2744 2.9e-307 hypothetical protein TcasGA2_TC013472 [Tribolium castaneum] 642923411 XM_008195512.1 102 6.10457e-43 PREDICTED: Tribolium castaneum collagen alpha-2(IV) chain (LOC103313111), mRNA K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 P17140 2109 5.0e-235 Collagen alpha-2(IV) chain OS=Caenorhabditis elegans GN=let-2 PE=1 SV=2 PF06331//PF01413//PF04710 Transcription factor TFIIH complex subunit Tfb5//C-terminal tandem repeated domain in type 4 procollagen//Pellino GO:0008063//GO:0006289//GO:0006355 Toll signaling pathway//nucleotide-excision repair//regulation of transcription, DNA-templated GO:0005201 extracellular matrix structural constituent GO:0000439//GO:0005578//GO:0005581 core TFIIH complex//proteinaceous extracellular matrix//collagen trimer KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.36764 BP_3 489.31 2.98 8193 557211143 CDJ50285.1 179 9.3e-10 hypothetical protein EBH_0032330 [Eimeria brunetti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00977 Histidine biosynthesis protein GO:0000105 histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.36765 BP_3 37.20 20.86 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36766 BP_3 784.54 3.40 11412 642919281 XP_008191807.1 1507 1.3e-163 PREDICTED: coiled-coil domain-containing protein 85C [Tribolium castaneum] 332376520 BT128443.1 148 2.78063e-68 Dendroctonus ponderosae clone DPO1136_F01 unknown mRNA K07199 PRKAB 5'-AMP-activated protein kinase, regulatory beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07199 Q5BIS9 672 3.6e-68 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus GN=PRKAB1 PE=2 SV=3 PF00170//PF06495//PF00096//PF03462//PF06005//PF00098//PF06156//PF02148//PF02922//PF12937//PF00076//PF04739//PF13912//PF06621//PF00320//PF01907//PF03286//PF08675//PF07503//PF00992//PF07776//PF06467//PF13465//PF05443//PF05130//PF02892//PF16622//PF00646//PF03836 bZIP transcription factor//Fruit fly transformer protein//Zinc finger, C2H2 type//PCRF domain//Protein of unknown function (DUF904)//Zinc knuckle//Protein of unknown function (DUF972)//Zn-finger in ubiquitin-hydrolases and other protein//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//F-box-like//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//5'-AMP-activated protein kinase beta subunit, interaction domain//C2H2-type zinc finger//Single-minded protein C-terminus//GATA zinc finger//Ribosomal protein L37e//Pox virus Ag35 surface protein//RNA binding domain//HypF finger//Troponin//Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//FlgN protein//BED zinc finger//zinc-finger C2H2-type//F-box domain//RasGAP C-terminus GO:0006260//GO:0006415//GO:0005975//GO:0042254//GO:0007264//GO:0006355//GO:0051252//GO:0046660//GO:0044780//GO:0000917//GO:0043093//GO:0006397//GO:0006402//GO:0006449//GO:0006412 DNA replication//translational termination//carbohydrate metabolic process//ribosome biogenesis//small GTPase mediated signal transduction//regulation of transcription, DNA-templated//regulation of RNA metabolic process//female sex differentiation//bacterial-type flagellum assembly//barrier septum assembly//FtsZ-dependent cytokinesis//mRNA processing//mRNA catabolic process//regulation of translational termination//translation GO:0003735//GO:0003700//GO:0003676//GO:0046872//GO:0004535//GO:0043565//GO:0008270//GO:0005096//GO:0004553//GO:0003677//GO:0003723//GO:0005515//GO:0016149 structural constituent of ribosome//transcription factor activity, sequence-specific DNA binding//nucleic acid binding//metal ion binding//poly(A)-specific ribonuclease activity//sequence-specific DNA binding//zinc ion binding//GTPase activator activity//hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding//RNA binding//protein binding//translation release factor activity, codon specific GO:0018444//GO:0005861//GO:0005667//GO:0005622//GO:0005840//GO:0005737//GO:0005634//GO:0019031 translation release factor complex//troponin complex//transcription factor complex//intracellular//ribosome//cytoplasm//nucleus//viral envelope KOG1721 FOG: Zn-finger Cluster-8309.36768 BP_3 49.28 1.09 2478 642915413 XP_008190604.1 2751 1.6e-308 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform X1 [Tribolium castaneum] 768434134 XM_011560159.1 553 0 PREDICTED: Plutella xylostella H(+)/Cl(-) exchange transporter 5-like (LOC105389096), mRNA K05012 CLCN3_4_5 chloride channel 3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K05012 P51792 1866 2.8e-207 H(+)/Cl(-) exchange transporter 3 OS=Rattus norvegicus GN=Clcn3 PE=2 SV=2 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0475 Cl- channel CLC-3 and related proteins (CLC superfamily) Cluster-8309.36769 BP_3 373.39 5.16 3779 478255961 ENN76162.1 1776 2.8e-195 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 Q8WY07 1135 2.5e-122 Cationic amino acid transporter 3 OS=Homo sapiens GN=SLC7A3 PE=1 SV=1 PF00324//PF15020//PF13520 Amino acid permease//Cation channel sperm-associated protein subunit delta//Amino acid permease GO:0006865//GO:0003333//GO:0055085//GO:0006810 amino acid transport//amino acid transmembrane transport//transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0036128//GO:0016020 CatSper complex//membrane -- -- Cluster-8309.36771 BP_3 6588.22 69.82 4840 91088817 XP_969793.1 2019 2.4e-223 PREDICTED: adenylosuccinate lyase [Tribolium castaneum]>gi|270012328|gb|EFA08776.1| hypothetical protein TcasGA2_TC006466 [Tribolium castaneum] 644999964 XM_001607942.3 153 1.95185e-71 PREDICTED: Nasonia vitripennis adenylosuccinate lyase (LOC100124133), mRNA K01756 purB, ADSL adenylosuccinate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01756 P21265 1603 1.7e-176 Adenylosuccinate lyase OS=Gallus gallus GN=ADSL PE=2 SV=2 PF01284//PF01607 Membrane-associating domain//Chitin binding Peritrophin-A domain GO:0006522//GO:0006144//GO:0006531//GO:0006030//GO:0009152 alanine metabolic process//purine nucleobase metabolic process//aspartate metabolic process//chitin metabolic process//purine ribonucleotide biosynthetic process GO:0008061//GO:0004018 chitin binding//N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GO:0016020//GO:0005576 membrane//extracellular region KOG2700 Adenylosuccinate lyase Cluster-8309.36774 BP_3 7837.71 1270.56 589 91080615 XP_974171.1 778 2.3e-80 PREDICTED: 60S ribosomal protein L21 [Tribolium castaneum]>gi|270005820|gb|EFA02268.1| hypothetical protein TcasGA2_TC007932 [Tribolium castaneum] -- -- -- -- -- K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 P46778 571 9.7e-58 60S ribosomal protein L21 OS=Homo sapiens GN=RPL21 PE=1 SV=2 PF01157 Ribosomal protein L21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.36775 BP_3 847.00 30.74 1620 571330966 AHF27415.1 878 1.6e-91 putative sugar transporter 3_1 [Phaedon cochleariae]>gi|571330968|gb|AHF27416.1| putative sugar transporter 3_2 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- Q7PIR5 438 7.0e-42 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.36776 BP_3 14655.13 682.97 1326 189240524 XP_971875.2 1968 5.4e-218 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] 62083392 AY961519.1 467 0 Lysiphlebus testaceipes ribosomal protein L3 (RpL3) mRNA, complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 1812 2.7e-201 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.36778 BP_3 1611.26 17.80 4655 642922405 XP_008193143.1 983 3.1e-103 PREDICTED: tetratricopeptide repeat protein 14 isoform X2 [Tribolium castaneum] 642922404 XM_008194921.1 226 4.93077e-112 PREDICTED: Tribolium castaneum tetratricopeptide repeat protein 14 (LOC663177), transcript variant X2, mRNA -- -- -- -- Q9VGU5 596 9.7e-60 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF01080//PF13181//PF11744//PF15741//PF05053//PF13174//PF13371//PF09726//PF02724//PF00515//PF13374//PF13176//PF10486//PF13414 Presenilin//Tetratricopeptide repeat//Aluminium activated malate transporter//Ligand-dependent nuclear receptor-interacting factor 1//Menin//Tetratricopeptide repeat//Tetratricopeptide repeat//Transmembrane protein//CDC45-like protein//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Phosphoinositide 3-kinase gamma adapter protein p101 subunit//TPR repeat GO:0015743//GO:0006270//GO:0007165//GO:0006355 malate transport//DNA replication initiation//signal transduction//regulation of transcription, DNA-templated GO:0042974//GO:0005515//GO:0004190//GO:0046935 retinoic acid receptor binding//protein binding//aspartic-type endopeptidase activity//1-phosphatidylinositol-3-kinase regulator activity GO:0005667//GO:0005634//GO:0016021//GO:0005944 transcription factor complex//nucleus//integral component of membrane//phosphatidylinositol 3-kinase complex, class IB -- -- Cluster-8309.36779 BP_3 5941.81 223.87 1571 264667413 ACY71292.1 697 1.5e-70 ribosomal protein L27 [Chrysomela tremula] 264667412 GU120442.1 190 1.68727e-92 Chrysomela tremulae ribosomal protein L27 (RpL27) mRNA, complete cds K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 P61355 503 2.0e-49 60S ribosomal protein L27 OS=Gallus gallus GN=RPL27 PE=2 SV=2 PF01777 Ribosomal L27e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3418 60S ribosomal protein L27 Cluster-8309.36780 BP_3 540.46 1.97 13539 642929047 XP_008195667.1 13173 0.0e+00 PREDICTED: baculoviral IAP repeat-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10586 BIRC6, BRUCE baculoviral IAP repeat-containing protein 6 (apollon) http://www.genome.jp/dbget-bin/www_bget?ko:K10586 O88738 3109 0.0e+00 Baculoviral IAP repeat-containing protein 6 OS=Mus musculus GN=Birc6 PE=1 SV=2 PF12356//PF00844 Protein of unknown function (DUF3643)//Geminivirus coat protein/nuclear export factor BR1 family GO:0032465//GO:0006915//GO:0016567 regulation of cytokinesis//apoptotic process//protein ubiquitination GO:0004842//GO:0005198 ubiquitin-protein transferase activity//structural molecule activity GO:0019028 viral capsid KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.36781 BP_3 34.47 0.35 5088 270008438 EFA04886.1 1456 4.9e-158 hypothetical protein TcasGA2_TC014948 [Tribolium castaneum] 817062637 XM_012397560.1 105 9.89372e-45 PREDICTED: Athalia rosae arginine-glutamic acid dipeptide repeats protein (LOC105684303), transcript variant X5, mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q9P2R6 622 1.0e-62 Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens GN=RERE PE=1 SV=2 PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667 transcription factor complex KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.36783 BP_3 725.02 16.96 2352 189237983 XP_001814292.1 711 5.5e-72 PREDICTED: filaggrin-2 [Tribolium castaneum]>gi|270006655|gb|EFA03103.1| hypothetical protein TcasGA2_TC013013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82120 156 5.1e-09 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.36784 BP_3 798.24 7.62 5339 817065189 XP_012254374.1 340 1.3e-28 PREDICTED: uncharacterized protein LOC105685104 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q9YMJ7 236 6.1e-18 Envelope fusion protein OS=Lymantria dispar multicapsid nuclear polyhedrosis virus GN=LdOrf-130 PE=3 SV=1 PF05929//PF04111//PF07851//PF10186//PF01576//PF04728//PF04799//PF04857//PF01733 Phage capsid scaffolding protein (GPO) serine peptidase//Autophagy protein Apg6//TMPIT-like protein//Vacuolar sorting 38 and autophagy-related subunit 14//Myosin tail//Lipoprotein leucine-zipper//fzo-like conserved region//CAF1 family ribonuclease//Nucleoside transporter GO:0015858//GO:0006810//GO:0006914//GO:0008053//GO:0010508//GO:0019069 nucleoside transport//transport//autophagy//mitochondrial fusion//positive regulation of autophagy//viral capsid assembly GO:0003924//GO:0003774//GO:0005337 GTPase activity//motor activity//nucleoside transmembrane transporter activity GO:0019867//GO:0016459//GO:0016021//GO:0005634//GO:0005741 outer membrane//myosin complex//integral component of membrane//nucleus//mitochondrial outer membrane -- -- Cluster-8309.36787 BP_3 10.65 1.68 597 642934971 XP_008196003.1 427 1.2e-39 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 41 4.16947e-10 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36789 BP_3 2756.00 97.73 1651 91085025 XP_973732.1 2245 5.1e-250 PREDICTED: mitochondrial-processing peptidase subunit beta [Tribolium castaneum]>gi|270008520|gb|EFA04968.1| hypothetical protein TcasGA2_TC015046 [Tribolium castaneum] 332373533 BT126946.1 477 0 Dendroctonus ponderosae clone DPO022_F23 unknown mRNA K17732 PMPCB, MAS1 mitochondrial-processing peptidase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17732 Q3SZ71 1520 2.5e-167 Mitochondrial-processing peptidase subunit beta OS=Bos taurus GN=PMPCB PE=2 SV=1 PF08367 Peptidase M16C associated GO:0006508 proteolysis GO:0046872//GO:0004222//GO:0008270 metal ion binding//metalloendopeptidase activity//zinc ion binding -- -- KOG0960 Mitochondrial processing peptidase, beta subunit, and related enzymes (insulinase superfamily) Cluster-8309.36790 BP_3 176.24 8.44 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36791 BP_3 192.11 2.55 3926 546683623 ERL93411.1 389 2.0e-34 hypothetical protein D910_10703 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16554 Dimerisation domain of d-ornithine 4,5-aminomutase -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.36795 BP_3 1251.53 22.34 2992 478257994 ENN78132.1 1444 7.0e-157 hypothetical protein YQE_05286, partial [Dendroctonus ponderosae] 815908496 XM_003488754.2 48 2.81013e-13 PREDICTED: Bombus impatiens protein SEC13 homolog (LOC100746611), mRNA K14004 SEC13 protein transport protein SEC13 http://www.genome.jp/dbget-bin/www_bget?ko:K14004 Q9D1M0 1099 2.9e-118 Protein SEC13 homolog OS=Mus musculus GN=Sec13 PE=2 SV=3 PF00400//PF16473//PF02538//PF00558 WD domain, G-beta repeat//Domain of unknown function (DUF5051)//Hydantoinase B/oxoprolinase//Vpu protein GO:0019076//GO:0006812//GO:0032801 viral release from host cell//cation transport//receptor catabolic process GO:0003824//GO:0005261//GO:0005515//GO:0003676 catalytic activity//cation channel activity//protein binding//nucleic acid binding GO:0033644 host cell membrane KOG1332 Vesicle coat complex COPII, subunit SEC13 Cluster-8309.36796 BP_3 6665.00 220.75 1747 556505459 YP_008757556.1 934 5.6e-98 NADH dehydrogenase subunit 2 (mitochondrion) [Batocera lineolata]>gi|359294282|gb|AEV21651.1| NADH dehydrogenase subunit 2 [Batocera lineolata] 359294281 JN986793.1 1081 0 Batocera lineolata mitochondrion, complete genome K03879 ND2 NADH-ubiquinone oxidoreductase chain 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03879 P03895 421 7.1e-40 NADH-ubiquinone oxidoreductase chain 2 OS=Drosophila yakuba GN=mt:ND2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36797 BP_3 4747.62 27.82 8516 478252904 ENN73288.1 2585 9.9e-289 hypothetical protein YQE_10052, partial [Dendroctonus ponderosae] 332373611 BT126985.1 410 0 Dendroctonus ponderosae clone DPO0910_M08 unknown mRNA K05677 ABCD3, PMP70 ATP-binding cassette, subfamily D (ALD), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05677 P28288 1838 1.7e-203 ATP-binding cassette sub-family D member 3 OS=Homo sapiens GN=ABCD3 PE=1 SV=1 PF00005//PF00262//PF06448//PF09266//PF13304//PF07127//PF02854//PF06472 ABC transporter//Calreticulin family//Domain of Unknown Function (DUF1081)//Viral DNA topoisomerase I, N-terminal//AAA domain, putative AbiEii toxin, Type IV TA system//Late nodulin protein//MIF4G domain//ABC transporter transmembrane region 2 GO:0009878//GO:0006869//GO:0006457//GO:0006265//GO:0006810//GO:0055085 nodule morphogenesis//lipid transport//protein folding//DNA topological change//transport//transmembrane transport GO:0046872//GO:0005509//GO:0005515//GO:0003916//GO:0005319//GO:0003677//GO:0003723//GO:0042626//GO:0016887//GO:0051082//GO:0005524 metal ion binding//calcium ion binding//protein binding//DNA topoisomerase activity//lipid transporter activity//DNA binding//RNA binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//unfolded protein binding//ATP binding GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane KOG0060 Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis) Cluster-8309.36799 BP_3 675.11 6.75 5114 642932256 XP_008197035.1 1291 6.6e-139 PREDICTED: uncharacterized protein CG7065 homolog isoform X2 [Tribolium castaneum] 805785462 XM_012284975.1 63 2.21442e-21 PREDICTED: Megachile rotundata uncharacterized protein CG7065-like (LOC100874663), transcript variant X3, mRNA -- -- -- -- Q7YZA2 382 6.9e-35 Uncharacterized protein CG7065 OS=Drosophila melanogaster GN=CG7065 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36800 BP_3 73.00 0.45 8100 642921046 XP_008192669.1 7635 0.0e+00 PREDICTED: low-density lipoprotein receptor-related protein 4 isoform X2 [Tribolium castaneum]>gi|270005136|gb|EFA01584.1| hypothetical protein TcasGA2_TC007146 [Tribolium castaneum] 642921045 XM_008194447.1 65 2.71728e-22 PREDICTED: Tribolium castaneum low-density lipoprotein receptor-related protein 4 (LOC663741), transcript variant X2, mRNA -- -- -- -- O75096 4284 0.0e+00 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF01731//PF00057//PF07645//PF02796 Arylesterase//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Helix-turn-helix domain of resolvase GO:0006310 DNA recombination GO:0000150//GO:0004064//GO:0005515//GO:0005509//GO:0003677 recombinase activity//arylesterase activity//protein binding//calcium ion binding//DNA binding GO:0016021 integral component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.36801 BP_3 11686.94 248.67 2557 91081945 XP_966990.1 2785 0.0e+00 PREDICTED: ATP-binding cassette sub-family F member 2 [Tribolium castaneum]>gi|270007325|gb|EFA03773.1| hypothetical protein TcasGA2_TC013884 [Tribolium castaneum] 642921870 XM_961897.3 497 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family F member 2 (LOC655357), mRNA K06185 ABCF2 ATP-binding cassette, subfamily F, member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06185 Q9UG63 2156 6.8e-241 ATP-binding cassette sub-family F member 2 OS=Homo sapiens GN=ABCF2 PE=1 SV=2 PF00025//PF01716//PF00004//PF13304//PF01926//PF00910//PF03969//PF06414//PF03193//PF00005 ADP-ribosylation factor family//Manganese-stabilising protein / photosystem II polypeptide//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//RNA helicase//AFG1-like ATPase//Zeta toxin//Protein of unknown function, DUF258//ABC transporter GO:0015979//GO:0006200//GO:0042549 photosynthesis//obsolete ATP catabolic process//photosystem II stabilization GO:0003723//GO:0005524//GO:0003924//GO:0016887//GO:0016301//GO:0005509//GO:0005525//GO:0003724 RNA binding//ATP binding//GTPase activity//ATPase activity//kinase activity//calcium ion binding//GTP binding//RNA helicase activity GO:0019898//GO:0009654//GO:0009523 extrinsic component of membrane//photosystem II oxygen evolving complex//photosystem II KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.36802 BP_3 1083.10 12.62 4428 642912483 XP_008200883.1 2111 4.7e-234 PREDICTED: protein hu-li tai shao isoform X1 [Tribolium castaneum] 752873776 XM_011255881.1 55 5.36297e-17 PREDICTED: Camponotus floridanus protein hu-li tai shao (LOC105250025), transcript variant X7, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1443 5.6e-158 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36804 BP_3 66.88 0.48 6999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00641//PF00894 Zn-finger in Ran binding protein and others//Luteovirus coat protein -- -- GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.36805 BP_3 3346.32 23.80 7069 642914570 XP_008190269.1 2875 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 10-like [Tribolium castaneum] -- -- -- -- -- K09530 DNAJC10 DnaJ homolog subfamily C member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09530 Q498R3 1401 6.6e-153 DnaJ homolog subfamily C member 10 OS=Rattus norvegicus GN=Dnajc10 PE=2 SV=2 PF01216//PF00085//PF08534//PF00578 Calsequestrin//Thioredoxin//Redoxin//AhpC/TSA family GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0005509//GO:0016491 antioxidant activity//calcium ion binding//oxidoreductase activity -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.36806 BP_3 2337.99 17.15 6862 189237348 XP_969332.2 5697 0.0e+00 PREDICTED: UDP-glucose:glycoprotein glucosyltransferase [Tribolium castaneum]>gi|642923178|ref|XP_008193642.1| PREDICTED: UDP-glucose:glycoprotein glucosyltransferase [Tribolium castaneum] 815794682 XM_012362561.1 201 5.75118e-98 PREDICTED: Linepithema humile UDP-glucose:glycoprotein glucosyltransferase (LOC105669544), mRNA K11718 HUGT UDP-glucose:glycoprotein glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11718 Q09332 3802 0.0e+00 UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster GN=Ugt PE=1 SV=2 PF00110//PF01501//PF00230//PF06427 wnt family//Glycosyl transferase family 8//Major intrinsic protein//UDP-glucose:Glycoprotein Glucosyltransferase GO:0006486//GO:0006810//GO:0016055//GO:0007275//GO:0007165 protein glycosylation//transport//Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102//GO:0003980//GO:0005215//GO:0016757 receptor binding//UDP-glucose:glycoprotein glucosyltransferase activity//transporter activity//transferase activity, transferring glycosyl groups GO:0016020//GO:0005576 membrane//extracellular region KOG1879 UDP-glucose:glycoprotein glucosyltransferase Cluster-8309.36810 BP_3 121.04 0.57 10583 642911349 XP_008199384.1 4646 0.0e+00 PREDICTED: uncharacterized protein LOC659886 isoform X1 [Tribolium castaneum] 642911358 XM_008201167.1 137 3.3585e-62 PREDICTED: Tribolium castaneum uncharacterized LOC659886 (LOC659886), transcript variant X6, mRNA -- -- -- -- B6RSP1 355 1.9e-31 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36811 BP_3 46.54 0.82 3021 795072296 XP_011875580.1 268 1.6e-20 PREDICTED: protein vein isoform X2 [Vollenhovia emeryi] 642924274 XM_008196005.1 39 2.85784e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103313241 (LOC103313241), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00008//PF07645//PF13895 EGF-like domain//Calcium-binding EGF domain//Immunoglobulin domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.36813 BP_3 534.32 23.95 1367 642935794 XP_008198177.1 361 1.2e-31 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35566 196 6.8e-14 CD151 antigen OS=Mus musculus GN=Cd151 PE=2 SV=2 PF00335//PF02203 Tetraspanin family//Tar ligand binding domain homologue GO:0007165//GO:0006935 signal transduction//chemotaxis GO:0004888 transmembrane signaling receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.36816 BP_3 90.33 0.91 5096 642917385 XP_008199669.1 1771 1.4e-194 PREDICTED: uncharacterized protein LOC658463 [Tribolium castaneum]>gi|270003013|gb|EEZ99460.1| hypothetical protein TcasGA2_TC000026 [Tribolium castaneum] -- -- -- -- -- K18586 COQ4 ubiquinone biosynthesis protein COQ4 http://www.genome.jp/dbget-bin/www_bget?ko:K18586 Q1HPV1 735 8.1e-76 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial OS=Bombyx mori PE=2 SV=1 PF05271//PF05019 Tobravirus 2B protein//Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GO:0006744//GO:0019089 ubiquinone biosynthetic process//transmission of virus -- -- -- -- KOG3244 Protein involved in ubiquinone biosynthesis Cluster-8309.36818 BP_3 1316.48 14.50 4667 91077504 XP_966852.1 2801 0.0e+00 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P26779 406 1.0e-37 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF05184//PF02627 Saposin-like type B, region 1//Carboxymuconolactone decarboxylase family GO:0006629//GO:0055114 lipid metabolic process//oxidation-reduction process GO:0051920 peroxiredoxin activity -- -- -- -- Cluster-8309.36819 BP_3 85.45 0.39 10898 642940144 XP_008200104.1 3309 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H269 1673 2.9e-184 Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens GN=VPS16 PE=1 SV=2 PF04841//PF04840 Vps16, N-terminal region//Vps16, C-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.36820 BP_3 56.00 2.44 1396 642913031 XP_008201359.1 654 1.3e-65 PREDICTED: proclotting enzyme-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81187 151 1.2e-08 Complement factor B OS=Bos taurus GN=CFB PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.36821 BP_3 9028.00 175.65 2769 91087467 XP_966334.1 2492 2.0e-278 PREDICTED: ATP synthase subunit alpha, mitochondrial [Tribolium castaneum]>gi|270010980|gb|EFA07428.1| hypothetical protein TcasGA2_TC008728 [Tribolium castaneum] 807044009 XM_004537394.2 644 0 PREDICTED: Ceratitis capitata ATP synthase subunit alpha, mitochondrial (LOC101456141), mRNA K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 P80021 2216 8.1e-248 ATP synthase subunit alpha, mitochondrial OS=Sus scrofa GN=ATP5A1 PE=1 SV=2 PF02874//PF00306//PF00006 ATP synthase alpha/beta family, beta-barrel domain//ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, nucleotide-binding domain GO:0015991//GO:0006119//GO:0046034//GO:0015992//GO:0015986 ATP hydrolysis coupled proton transport//oxidative phosphorylation//ATP metabolic process//proton transport//ATP synthesis coupled proton transport GO:0016820//GO:0005524//GO:0046961//GO:0046933 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//ATP binding//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0033178//GO:0045261 proton-transporting ATP synthase complex//proton-transporting two-sector ATPase complex, catalytic domain//proton-transporting ATP synthase complex, catalytic core F(1) KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-8309.36824 BP_3 1055.31 5.20 10082 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 541 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF08165//PF01436//PF14634//PF03884//PF01601//PF00097//PF04513//PF13639//PF04566//PF10588//PF00651 FerA (NUC095) domain//NHL repeat//zinc-RING finger domain//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//Zinc finger, C3HC4 type (RING finger)//Baculovirus polyhedron envelope protein, PEP, C terminus//Ring finger domain//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//BTB/POZ domain GO:0055114//GO:0046813//GO:0006206//GO:0061025//GO:0006144//GO:0006351 oxidation-reduction process//receptor-mediated virion attachment to host cell//pyrimidine nucleobase metabolic process//membrane fusion//purine nucleobase metabolic process//transcription, DNA-templated GO:0008270//GO:0005198//GO:0003899//GO:0046872//GO:0016491//GO:0005515//GO:0003677 zinc ion binding//structural molecule activity//DNA-directed RNA polymerase activity//metal ion binding//oxidoreductase activity//protein binding//DNA binding GO:0005730//GO:0019028//GO:0016021//GO:0019031 nucleolus//viral capsid//integral component of membrane//viral envelope KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.36825 BP_3 252.47 6.26 2237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36826 BP_3 864.72 10.27 4350 478263033 ENN81433.1 728 1.1e-73 hypothetical protein YQE_02126, partial [Dendroctonus ponderosae]>gi|546686062|gb|ERL95462.1| hypothetical protein D910_12724 [Dendroctonus ponderosae] 831528427 XM_012864660.1 115 2.33242e-50 PREDICTED: Fundulus heteroclitus malate dehydrogenase 2, NAD (mitochondrial) (mdh2), mRNA K00026 MDH2 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00026 P40926 510 8.5e-50 Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 PF01073//PF02866//PF01113//PF00056//PF02882 3-beta hydroxysteroid dehydrogenase/isomerase family//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Dihydrodipicolinate reductase, N-terminus//lactate/malate dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0008210//GO:0009089//GO:0009085//GO:0046487//GO:0009396//GO:0008207//GO:0055114//GO:0006694//GO:0008209 estrogen metabolic process//lysine biosynthetic process via diaminopimelate//lysine biosynthetic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process GO:0003854//GO:0003824//GO:0008839//GO:0016616//GO:0004488//GO:0016491 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//4-hydroxy-tetrahydrodipicolinate reductase//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-8309.36827 BP_3 134.72 0.78 8587 478252904 ENN73288.1 2609 1.6e-291 hypothetical protein YQE_10052, partial [Dendroctonus ponderosae] 332373611 BT126985.1 410 0 Dendroctonus ponderosae clone DPO0910_M08 unknown mRNA K05677 ABCD3, PMP70 ATP-binding cassette, subfamily D (ALD), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05677 P28288 1838 1.7e-203 ATP-binding cassette sub-family D member 3 OS=Homo sapiens GN=ABCD3 PE=1 SV=1 PF13304//PF07127//PF02854//PF06472//PF00005//PF00262//PF06448//PF09266 AAA domain, putative AbiEii toxin, Type IV TA system//Late nodulin protein//MIF4G domain//ABC transporter transmembrane region 2//ABC transporter//Calreticulin family//Domain of Unknown Function (DUF1081)//Viral DNA topoisomerase I, N-terminal GO:0009878//GO:0006457//GO:0006869//GO:0006265//GO:0055085//GO:0006810 nodule morphogenesis//protein folding//lipid transport//DNA topological change//transmembrane transport//transport GO:0005509//GO:0046872//GO:0003723//GO:0003677//GO:0005319//GO:0003916//GO:0005515//GO:0051082//GO:0016887//GO:0042626//GO:0005524 calcium ion binding//metal ion binding//RNA binding//DNA binding//lipid transporter activity//DNA topoisomerase activity//protein binding//unfolded protein binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane KOG0060 Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis) Cluster-8309.36831 BP_3 129.70 0.72 8968 91083999 XP_975264.1 1320 5.0e-142 PREDICTED: protein FAM13A [Tribolium castaneum]>gi|270006707|gb|EFA03155.1| hypothetical protein TcasGA2_TC013074 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYW0 267 2.6e-21 Protein FAM13A OS=Bos taurus GN=FAM13A PE=2 SV=1 PF11365 Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy -- -- GO:0005615 extracellular space -- -- Cluster-8309.36832 BP_3 1221.90 8.54 7185 546673612 ERL85176.1 11605 0.0e+00 hypothetical protein D910_02598 [Dendroctonus ponderosae] 642911110 XM_008202361.1 2073 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 5750 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF01108//PF03739//PF13895//PF00041//PF02480//PF16656 Tissue factor//Predicted permease YjgP/YjgQ family//Immunoglobulin domain//Fibronectin type III domain//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36833 BP_3 37.42 1.80 1294 264667343 ACY71257.1 1048 2.5e-111 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 558 6.8e-56 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF03868//PF01159 Ribosomal protein L6, N-terminal domain//Ribosomal protein L6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1694 60s ribosomal protein L6 Cluster-8309.36838 BP_3 1222.38 11.93 5231 642924644 XP_008194377.1 4519 0.0e+00 PREDICTED: tensin isoform X3 [Tribolium castaneum] 642924663 XM_008196165.1 42 1.06903e-09 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X13, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q04205 811 1.3e-84 Tensin OS=Gallus gallus GN=TNS PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.36839 BP_3 10093.74 76.30 6668 642922678 XP_008193276.1 5040 0.0e+00 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X8 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 1706 2.7e-188 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF13895//PF02443//PF00057//PF01086//PF00815//PF10584 Immunoglobulin domain//Circovirus capsid protein//Low-density lipoprotein receptor domain class A//Clathrin light chain//Histidinol dehydrogenase//Proteasome subunit A N-terminal signature GO:0006511//GO:0000105//GO:0019069//GO:0016192//GO:0006886//GO:0055114 ubiquitin-dependent protein catabolic process//histidine biosynthetic process//viral capsid assembly//vesicle-mediated transport//intracellular protein transport//oxidation-reduction process GO:0051287//GO:0005515//GO:0004175//GO:0005198//GO:0004399//GO:0008270 NAD binding//protein binding//endopeptidase activity//structural molecule activity//histidinol dehydrogenase activity//zinc ion binding GO:0030132//GO:0042025//GO:0019773//GO:0030130 clathrin coat of coated pit//host cell nucleus//proteasome core complex, alpha-subunit complex//clathrin coat of trans-Golgi network vesicle KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.3684 BP_3 16172.15 923.27 1136 189236939 XP_970278.2 267 8.1e-21 PREDICTED: histidine-rich glycoprotein [Tribolium castaneum]>gi|270008064|gb|EFA04512.1| hypothetical protein TcasGA2_TC016307 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 203 8.8e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.36840 BP_3 52.44 0.79 3486 478252457 ENN72879.1 2104 2.4e-233 hypothetical protein YQE_10449, partial [Dendroctonus ponderosae] -- -- -- -- -- K09531 DNAJC11 DnaJ homolog subfamily C member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09531 Q5U458 1166 5.8e-126 DnaJ homolog subfamily C member 11 OS=Mus musculus GN=Dnajc11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0718 Molecular chaperone (DnaJ superfamily) Cluster-8309.36841 BP_3 3691.32 37.46 5041 332375044 AEE62663.1 3535 0.0e+00 unknown [Dendroctonus ponderosae]>gi|478250038|gb|ENN70544.1| hypothetical protein YQE_12719, partial [Dendroctonus ponderosae]>gi|546672620|gb|ERL84416.1| hypothetical protein D910_01849 [Dendroctonus ponderosae] 642932042 XM_969767.3 504 0 PREDICTED: Tribolium castaneum probable aconitate hydratase, mitochondrial (LOC663732), mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 Q99KI0 3035 0.0e+00 Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1 PF00330//PF00694 Aconitase family (aconitate hydratase)//Aconitase C-terminal domain GO:0008152 metabolic process -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.36845 BP_3 59.87 0.78 3994 642910971 XP_008193488.1 486 1.1e-45 PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910973|ref|XP_008193489.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910975|ref|XP_008193490.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910977|ref|XP_008193491.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910979|ref|XP_008193492.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|270015145|gb|EFA11593.1| transforming acidic coiled-coil protein [Tribolium castaneum] -- -- -- -- -- K14281 TACC1 transforming acidic coiled-coil-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14281 O95359 166 6.0e-10 Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens GN=TACC2 PE=1 SV=3 PF08702//PF12740//PF07224//PF16719//PF11744//PF10186//PF07851//PF04632 Fibrinogen alpha/beta chain family//Chlorophyllase enzyme//Chlorophyllase//SAWADEE domain//Aluminium activated malate transporter//Vacuolar sorting 38 and autophagy-related subunit 14//TMPIT-like protein//Fusaric acid resistance protein family GO:0010508//GO:0006810//GO:0051258//GO:0015996//GO:0007165//GO:0030168//GO:0015994//GO:0015743 positive regulation of autophagy//transport//protein polymerization//chlorophyll catabolic process//signal transduction//platelet activation//chlorophyll metabolic process//malate transport GO:0003682//GO:0005102//GO:0030674//GO:0047746 chromatin binding//receptor binding//protein binding, bridging//chlorophyllase activity GO:0005577//GO:0016021//GO:0005886//GO:0000785 fibrinogen complex//integral component of membrane//plasma membrane//chromatin -- -- Cluster-8309.36846 BP_3 21811.02 343.63 3351 613485521 AHX26755.1 494 1.1e-46 ATF4 [Tribolium castaneum] 462302759 APGK01050095.1 54 1.45587e-16 Dendroctonus ponderosae Seq01050105, whole genome shotgun sequence K04374 ATF4, CREB2 cyclic AMP-dependent transcription factor ATF-4 http://www.genome.jp/dbget-bin/www_bget?ko:K04374 Q9GPH3 194 2.9e-13 Activating transcription factor of chaperone OS=Bombyx mori GN=ATFC PE=2 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36847 BP_3 921.81 24.12 2134 642922261 XP_008193083.1 862 1.5e-89 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62046 418 1.9e-39 Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Mus musculus GN=Lrch1 PE=1 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0532 Leucine-rich repeat (LRR) protein, contains calponin homology domain Cluster-8309.36848 BP_3 80.49 1.43 2999 91091818 XP_966528.1 1854 2.0e-204 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 1223 1.2e-132 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF03594//PF01134//PF02321//PF10613//PF00060 Benzoate membrane transport protein//Glucose inhibited division protein A//Outer membrane efflux protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0042919//GO:0007268//GO:0006810//GO:0008033//GO:0006811 signal transduction//benzoate transport//synaptic transmission//transport//tRNA processing//ion transport GO:0005215//GO:0005234//GO:0004970//GO:0005216//GO:0042925//GO:0050660 transporter activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//ion channel activity//benzoate transporter activity//flavin adenine dinucleotide binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.36850 BP_3 2676.73 21.97 6165 478260998 ENN80588.1 6830 0.0e+00 hypothetical protein YQE_02993, partial [Dendroctonus ponderosae] 884965815 XM_010892944.2 162 2.47264e-76 PREDICTED: Esox lucius HECT domain containing E3 ubiquitin protein ligase 1 (hectd1), transcript variant X6, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 4691 0.0e+00 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF13606//PF00023//PF06701 Ankyrin repeat//Ankyrin repeat//Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515 ubiquitin-protein transferase activity//metal ion binding//protein binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.36852 BP_3 468.47 46.72 775 478252045 ENN72476.1 632 2.6e-63 hypothetical protein YQE_10818, partial [Dendroctonus ponderosae] 241606024 XM_002406107.1 38 2.55318e-08 Ixodes scapularis merlin, putative, mRNA K16684 NF2 merlin http://www.genome.jp/dbget-bin/www_bget?ko:K16684 Q24564 228 7.5e-18 Moesin/ezrin/radixin homolog 2 OS=Drosophila melanogaster GN=Mer PE=1 SV=1 PF00769//PF03497 Ezrin/radixin/moesin family//Anthrax toxin LF subunit GO:0006171//GO:0009405 cAMP biosynthetic process//pathogenesis GO:0008294//GO:0008092 calcium- and calmodulin-responsive adenylate cyclase activity//cytoskeletal protein binding GO:0005737//GO:0005576//GO:0019898 cytoplasm//extracellular region//extrinsic component of membrane KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.36853 BP_3 5460.32 508.79 809 642933931 XP_008197572.1 570 4.2e-56 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 233 2.1e-18 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- -- -- Cluster-8309.36854 BP_3 65.01 0.89 3819 546675355 ERL86565.1 422 2.9e-38 hypothetical protein D910_03972 [Dendroctonus ponderosae] 573889931 XM_006632666.1 92 1.24851e-37 PREDICTED: Lepisosteus oculatus zinc finger protein 36, C3H1 type-like 1-like (LOC102685396), mRNA K18753 ZFP36L butyrate response factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18753 Q07352 267 1.1e-21 Zinc finger protein 36, C3H1 type-like 1 OS=Homo sapiens GN=ZFP36L1 PE=1 SV=1 PF03791//PF00642 KNOX2 domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634 nucleus KOG1677 CCCH-type Zn-finger protein Cluster-8309.36855 BP_3 1642.11 7.22 11250 642913459 XP_008201021.1 2877 0.0e+00 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] 642913458 XM_008202799.1 192 9.51586e-93 PREDICTED: Tribolium castaneum uncharacterized LOC103315067 (LOC103315067), mRNA K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q9VAN0 507 4.9e-49 Probable phosphoserine aminotransferase OS=Drosophila melanogaster GN=CG11899 PE=2 SV=1 PF05206//PF03169 Methyltransferase TRM13//OPT oligopeptide transporter protein GO:0055085//GO:0008033 transmembrane transport//tRNA processing GO:0008168 methyltransferase activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.36856 BP_3 153.99 0.70 10963 642913459 XP_008201021.1 2877 0.0e+00 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] 642913458 XM_008202799.1 148 2.67087e-68 PREDICTED: Tribolium castaneum uncharacterized LOC103315067 (LOC103315067), mRNA K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q9VAN0 1068 4.2e-114 Probable phosphoserine aminotransferase OS=Drosophila melanogaster GN=CG11899 PE=2 SV=1 PF03169//PF03334//PF03581 OPT oligopeptide transporter protein//Na+/H+ antiporter subunit//Herpesvirus UL33-like protein GO:0019073//GO:0015992//GO:0015672//GO:0055085 viral DNA genome packaging//proton transport//monovalent inorganic cation transport//transmembrane transport GO:0005451 monovalent cation:proton antiporter activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.36857 BP_3 102.09 1.72 3152 642928964 XP_008195636.1 452 7.9e-42 PREDICTED: uncharacterized protein LOC103313636 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09119 SicP binding -- -- -- -- GO:0005615 extracellular space -- -- Cluster-8309.36858 BP_3 2319.77 19.97 5891 642938612 XP_008199865.1 2521 1.8e-281 PREDICTED: uncharacterized protein LOC655974, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36859 BP_3 3970.48 44.26 4616 642928992 XP_008195647.1 2657 2.4e-297 PREDICTED: endoplasmic reticulum metallopeptidase 1-like [Tribolium castaneum] 642930260 XM_966256.3 104 3.22596e-44 PREDICTED: Tribolium castaneum 40S ribosomal protein S29 (LOC659992), mRNA -- -- -- -- Q3UVK0 1041 2.4e-111 Endoplasmic reticulum metallopeptidase 1 OS=Mus musculus GN=Ermp1 PE=2 SV=2 PF01546//PF15957//PF00253//PF00060//PF15168 Peptidase family M20/M25/M40//Commissureless//Ribosomal protein S14p/S29e//Ligand-gated ion channel//Triple QxxK/R motif-containing protein family GO:0006811//GO:0042254//GO:0007411//GO:0007165//GO:0008152//GO:0006412//GO:0007268 ion transport//ribosome biogenesis//axon guidance//signal transduction//metabolic process//translation//synaptic transmission GO:0003735//GO:0016787//GO:0004970 structural constituent of ribosome//hydrolase activity//ionotropic glutamate receptor activity GO:0016020//GO:0005622//GO:0005840//GO:0005789 membrane//intracellular//ribosome//endoplasmic reticulum membrane KOG2194 Aminopeptidases of the M20 family Cluster-8309.36860 BP_3 2.00 0.42 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36861 BP_3 1046.52 14.51 3769 478263359 ENN81735.1 159 9.0e-08 hypothetical protein YQE_01874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36862 BP_3 15914.46 79.65 9922 91088831 XP_970461.1 3072 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X1 [Tribolium castaneum]>gi|270012333|gb|EFA08781.1| hypothetical protein TcasGA2_TC006471 [Tribolium castaneum] 645001221 XM_001601899.3 112 2.48575e-48 PREDICTED: Nasonia vitripennis 60S ribosomal protein L34-like (LOC100113629), mRNA K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O88813 1719 1.2e-189 Long-chain-fatty-acid--CoA ligase 5 OS=Rattus norvegicus GN=Acsl5 PE=1 SV=1 PF01199//PF00501//PF05008//PF01363//PF16053 Ribosomal protein L34e//AMP-binding enzyme//Vesicle transport v-SNARE protein N-terminus//FYVE zinc finger//Mitochondrial 28S ribosomal protein S34 GO:0042254//GO:0008152//GO:0006412//GO:0006886 ribosome biogenesis//metabolic process//translation//intracellular protein transport GO:0003735//GO:0046872//GO:0003824 structural constituent of ribosome//metal ion binding//catalytic activity GO:0016020//GO:0005622//GO:0005840//GO:0005739 membrane//intracellular//ribosome//mitochondrion KOG1256 Long-chain acyl-CoA synthetases (AMP-forming) Cluster-8309.36863 BP_3 199.74 2.20 4677 189241960 XP_968710.2 3341 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 9 isoform X2 [Tribolium castaneum] 805759873 XM_012297744.1 247 1.04989e-123 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 1.9e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00018//PF14604//PF00621 SH3 domain//Variant SH3 domain//RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.36864 BP_3 22.76 1.27 1156 820805582 AKG92782.1 545 4.8e-53 Pxs [Leptinotarsa decemlineata] 564234777 XM_006274259.1 76 2.90518e-29 PREDICTED: Alligator mississippiensis transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA K09070 TCF15, PARAXIS transcription factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09070 Q60539 276 3.1e-23 Transcription factor 15 OS=Mesocricetus auratus GN=TCF15 PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.36865 BP_3 316.05 1.66 9450 332375166 AEE62724.1 996 2.0e-104 unknown [Dendroctonus ponderosae]>gi|478252403|gb|ENN72829.1| hypothetical protein YQE_10632, partial [Dendroctonus ponderosae]>gi|546680735|gb|ERL90961.1| hypothetical protein D910_08303 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 736 1.1e-75 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF10371//PF01073//PF01118//PF03015//PF13855//PF09107//PF01370//PF03435 Domain of unknown function//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//Male sterility protein//Leucine rich repeat//Elongation factor SelB, winged helix//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain GO:0008210//GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0001514//GO:0006448 estrogen metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//selenocysteine incorporation//regulation of translational elongation GO:0005525//GO:0003746//GO:0003723//GO:0003824//GO:0051287//GO:0016491//GO:0005515//GO:0080019//GO:0016620//GO:0016903//GO:0003854//GO:0050662//GO:0016616 GTP binding//translation elongation factor activity//RNA binding//catalytic activity//NAD binding//oxidoreductase activity//protein binding//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the aldehyde or oxo group of donors//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005840//GO:0005737 ribosome//cytoplasm KOG1221 Acyl-CoA reductase Cluster-8309.36866 BP_3 155.32 2.26 3603 642925601 XP_001812139.2 166 1.3e-08 PREDICTED: uncharacterized protein LOC660114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80060 132 4.8e-06 Protease inhibitors OS=Locusta migratoria PE=1 SV=2 PF04901//PF04048//PF05375 Receptor activity modifying family//Sec8 exocyst complex component specific domain//Pacifastin inhibitor (LCMII) GO:0015031//GO:0006886//GO:0006904//GO:0008277 protein transport//intracellular protein transport//vesicle docking involved in exocytosis//regulation of G-protein coupled receptor protein signaling pathway GO:0030414//GO:0008565 peptidase inhibitor activity//protein transporter activity GO:0000145//GO:0016021 exocyst//integral component of membrane -- -- Cluster-8309.36868 BP_3 11877.81 164.07 3781 752876259 XP_011255518.1 494 1.3e-46 PREDICTED: 60S ribosomal protein L44 [Camponotus floridanus] 642918893 XM_968530.2 160 1.95441e-75 PREDICTED: Tribolium castaneum 60S ribosomal protein L44 (LOC662436), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q9NB33 450 6.7e-43 60S ribosomal protein L44 OS=Ochlerotatus triseriatus GN=RpL44 PE=3 SV=3 PF02150//PF10152//PF00935 RNA polymerases M/15 Kd subunit//Predicted coiled-coil domain-containing protein (DUF2360)//Ribosomal protein L44 GO:0042254//GO:0006206//GO:0006412//GO:0006144//GO:0006351 ribosome biogenesis//pyrimidine nucleobase metabolic process//translation//purine nucleobase metabolic process//transcription, DNA-templated GO:0003735//GO:0003677//GO:0003899 structural constituent of ribosome//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0071203//GO:0005622//GO:0005840 nucleolus//WASH complex//intracellular//ribosome KOG3464 60S ribosomal protein L44 Cluster-8309.36869 BP_3 980.00 19.67 2693 642927468 XP_008195285.1 829 1.3e-85 PREDICTED: growth arrest-specific protein 1-like [Tribolium castaneum]>gi|270009958|gb|EFA06406.1| hypothetical protein TcasGA2_TC009285 [Tribolium castaneum] -- -- -- -- -- K06232 GAS1 growth arrest-specific 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06232 Q01721 262 3.0e-21 Growth arrest-specific protein 1 OS=Mus musculus GN=Gas1 PE=2 SV=2 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36870 BP_3 235.50 24.50 755 642931818 XP_008196746.1 346 3.7e-30 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q3THK7 282 4.0e-24 GMP synthase [glutamine-hydrolyzing] OS=Mus musculus GN=Gmps PE=1 SV=2 PF00958 GMP synthase C terminal domain GO:0006536//GO:0006144//GO:0006164//GO:0006177 glutamate metabolic process//purine nucleobase metabolic process//purine nucleotide biosynthetic process//GMP biosynthetic process GO:0003922//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//ATP binding -- -- KOG1622 GMP synthase Cluster-8309.36871 BP_3 4720.45 47.56 5076 642925960 XP_008195671.1 2730 9.1e-306 PREDICTED: neurotrypsin-like [Tribolium castaneum]>gi|270009237|gb|EFA05685.1| serine protease P153 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08762 744 7.3e-77 Neurotrypsin OS=Mus musculus GN=Prss12 PE=2 SV=1 PF00057//PF00530//PF01607//PF15494//PF00089//PF01380 Low-density lipoprotein receptor domain class A//Scavenger receptor cysteine-rich domain//Chitin binding Peritrophin-A domain//Scavenger receptor cysteine-rich domain//Trypsin//SIS domain GO:0006508//GO:0005975//GO:0007165//GO:0006030 proteolysis//carbohydrate metabolic process//signal transduction//chitin metabolic process GO:0030246//GO:0008061//GO:0008233//GO:0004252//GO:0005044//GO:0005515 carbohydrate binding//chitin binding//peptidase activity//serine-type endopeptidase activity//scavenger receptor activity//protein binding GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.36873 BP_3 240.38 2.17 5631 642927195 XP_008195175.1 2564 1.8e-286 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36874 BP_3 1400.82 8.34 8389 642933138 XP_008197272.1 7873 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 13 isoform X1 [Tribolium castaneum] 642933139 XM_008199051.1 239 5.28884e-119 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 3.1e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF06333//PF02671 Mediator complex subunit 13 C-terminal//Paired amphipathic helix repeat GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.36875 BP_3 42.63 0.66 3405 674656865 AIL26079.1 747 5.3e-76 ferritin 2 [Monochamus alternatus] 674656864 KJ872588.1 138 2.984e-63 Monochamus alternatus ferritin 2 mRNA, complete cds -- -- -- -- -- -- -- -- PF00210//PF07545//PF07473 Ferritin-like domain//Vestigial/Tondu family//Spasmodic peptide gm9a; conotoxin from Conus species GO:0009405//GO:0006879//GO:0006355 pathogenesis//cellular iron ion homeostasis//regulation of transcription, DNA-templated GO:0008199 ferric iron binding GO:0005634//GO:0005576 nucleus//extracellular region -- -- Cluster-8309.36876 BP_3 11.00 1.04 802 507188100 AGM39619.1 577 6.5e-57 nubbin protein long isoform [Tribolium castaneum] 642919203 XM_008193557.1 134 1.13899e-61 PREDICTED: Tribolium castaneum nubbin (LOC656845), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36877 BP_3 163.58 2.11 4025 478251563 ENN72025.1 1955 5.3e-216 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1Z8J0 1065 3.5e-114 CWF19-like protein 1 homolog OS=Drosophila melanogaster GN=CG7741 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.36879 BP_3 1568.77 51.85 1750 270016295 EFA12741.1 1660 3.7e-182 Rm62 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.91074e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1365 2.5e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF03141//PF04851 DEAD/DEAH box helicase//Putative S-adenosyl-L-methionine-dependent methyltransferase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0008168//GO:0003676//GO:0016787//GO:0003677 ATP binding//methyltransferase activity//nucleic acid binding//hydrolase activity//DNA binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.36880 BP_3 460.00 13.19 1973 642918053 XP_008198996.1 1358 4.4e-147 PREDICTED: nucleolar protein 11 [Tribolium castaneum]>gi|270004715|gb|EFA01163.1| hypothetical protein TcasGA2_TC010388 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INI5 218 2.8e-16 Nucleolar protein 11 OS=Xenopus laevis GN=nol11 PE=2 SV=2 PF00971//PF01335 EIAV coat protein, gp90//Death effector domain GO:0042981 regulation of apoptotic process GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0019031 viral envelope -- -- Cluster-8309.36881 BP_3 7431.00 460.22 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05180 DNL zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36882 BP_3 1266.00 7.33 8617 642931063 XP_008196196.1 1688 1.0e-184 PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|642931065|ref|XP_008196197.1| PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|270011892|gb|EFA08340.1| hypothetical protein TcasGA2_TC005983 [Tribolium castaneum] 195484142 XM_002090535.1 90 3.66186e-36 Drosophila yakuba RpS26 (Dyak\RpS26), partial mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 Q9GT45 503 1.1e-48 40S ribosomal protein S26 OS=Anopheles gambiae GN=RpS26 PE=3 SV=2 PF15473//PF01283 PEST, proteolytic signal-containing nuclear protein family//Ribosomal protein S26e GO:0042254//GO:0016567//GO:0006412 ribosome biogenesis//protein ubiquitination//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1768 40s ribosomal protein S26 Cluster-8309.36884 BP_3 368.43 2.19 8390 642926988 XP_008195092.1 1922 7.4e-212 PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum]>gi|642926990|ref|XP_008195093.1| PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum] 642926985 XM_008196869.1 122 5.79902e-54 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX27 (LOC103313489), mRNA K01320 F7 coagulation factor VII http://www.genome.jp/dbget-bin/www_bget?ko:K01320 P21902 337 1.9e-29 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF02468 Trypsin//Photosystem II reaction centre N protein (psbN) GO:0015979//GO:0006508 photosynthesis//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.36885 BP_3 5923.37 96.87 3239 478254773 ENN75009.1 1721 5.8e-189 hypothetical protein YQE_08326, partial [Dendroctonus ponderosae]>gi|546674398|gb|ERL85785.1| hypothetical protein D910_03200 [Dendroctonus ponderosae] 768418305 XM_011551531.1 267 5.52267e-135 PREDICTED: Plutella xylostella serine/threonine-protein phosphatase alpha-2 isoform (LOC105381736), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q6NVU2 1617 2.7e-178 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Xenopus tropicalis GN=ppp1cc PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.36887 BP_3 29.08 0.37 4070 642936644 XP_008198521.1 850 7.2e-88 PREDICTED: kinesin heavy chain [Tribolium castaneum] -- -- -- -- -- K10396 KIF5 kinesin family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10396 P17210 732 1.4e-75 Kinesin heavy chain OS=Drosophila melanogaster GN=Khc PE=1 SV=2 PF17078//PF16519//PF03999//PF07926//PF05384//PF10473//PF07989//PF10186//PF06156//PF04111//PF07851 SWI5-dependent HO expression protein 3//Tetramerisation domain of TRPM//Microtubule associated protein (MAP65/ASE1 family)//TPR/MLP1/MLP2-like protein//Sensor protein DegS//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Vacuolar sorting 38 and autophagy-related subunit 14//Protein of unknown function (DUF972)//Autophagy protein Apg6//TMPIT-like protein GO:0048309//GO:0051028//GO:0000910//GO:0000226//GO:0006914//GO:0007165//GO:0051262//GO:0010508//GO:0006260//GO:0006606 endoplasmic reticulum inheritance//mRNA transport//cytokinesis//microtubule cytoskeleton organization//autophagy//signal transduction//protein tetramerization//positive regulation of autophagy//DNA replication//protein import into nucleus GO:0008017//GO:0042803//GO:0008134//GO:0045502//GO:0016301 microtubule binding//protein homodimerization activity//transcription factor binding//dynein binding//kinase activity GO:0005667//GO:0030286//GO:0045298//GO:0005815//GO:0016021 transcription factor complex//dynein complex//tubulin complex//microtubule organizing center//integral component of membrane KOG0240 Kinesin (SMY1 subfamily) Cluster-8309.36888 BP_3 301.65 4.60 3451 478257812 ENN77955.1 340 8.4e-29 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0042254//GO:0001522//GO:0006464 ribosome biogenesis//pseudouridine synthesis//cellular protein modification process GO:0016151//GO:0030515 nickel cation binding//snoRNA binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.36890 BP_3 3409.48 88.20 2155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36891 BP_3 1255.62 5.37 11560 642929438 XP_008195840.1 3313 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X1 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 2545 2.4e-285 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF00520//PF00312//PF16519//PF12122 Ion transport protein//Ribosomal protein S15//Tetramerisation domain of TRPM//Cytoplasmic N-terminal domain of rhomboid serine protease GO:0051262//GO:0055085//GO:0006412//GO:0042254//GO:0006811 protein tetramerization//transmembrane transport//translation//ribosome biogenesis//ion transport GO:0005216//GO:0003735//GO:0004252 ion channel activity//structural constituent of ribosome//serine-type endopeptidase activity GO:0016021//GO:0005840//GO:0016020//GO:0005622 integral component of membrane//ribosome//membrane//intracellular KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.36892 BP_3 3655.91 55.30 3478 270016569 EFA13015.1 3609 0.0e+00 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] 831318133 XM_012836335.1 35 5.51433e-06 PREDICTED: Clupea harengus low density lipoprotein receptor-related protein 2 (lrp2), mRNA -- -- -- -- P35953 1725 8.8e-191 Very low-density lipoprotein receptor OS=Oryctolagus cuniculus GN=VLDLR PE=2 SV=1 PF00057//PF07645//PF08506//PF00002 Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Cse1//7 transmembrane receptor (Secretin family) GO:0007186//GO:0006886 G-protein coupled receptor signaling pathway//intracellular protein transport GO:0004930//GO:0005509//GO:0005515 G-protein coupled receptor activity//calcium ion binding//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.36895 BP_3 9.66 0.38 1531 270010395 EFA06843.1 1448 1.2e-157 hypothetical protein TcasGA2_TC009786 [Tribolium castaneum] 752877329 XM_011257793.1 133 7.97719e-61 PREDICTED: Camponotus floridanus serine--tRNA ligase, cytoplasmic (LOC105251197), mRNA K01875 SARS, serS seryl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01875 P26638 1170 8.7e-127 Serine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Sars PE=2 SV=3 PF00587 tRNA synthetase class II core domain (G, H, P, S and T) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG2509 Seryl-tRNA synthetase Cluster-8309.36896 BP_3 12126.65 110.67 5573 642933915 XP_008197565.1 1628 6.0e-178 PREDICTED: calreticulin [Tribolium castaneum]>gi|270013651|gb|EFA10099.1| hypothetical protein TcasGA2_TC012278 [Tribolium castaneum] 332373611 BT126985.1 410 0 Dendroctonus ponderosae clone DPO0910_M08 unknown mRNA K08057 CALR calreticulin http://www.genome.jp/dbget-bin/www_bget?ko:K08057 Q7Z1E6 1398 1.2e-152 Calreticulin OS=Bombyx mori GN=crt PE=1 SV=1 PF00262//PF07127//PF02854 Calreticulin family//Late nodulin protein//MIF4G domain GO:0009878//GO:0006457 nodule morphogenesis//protein folding GO:0005509//GO:0051082//GO:0046872//GO:0003723//GO:0005515 calcium ion binding//unfolded protein binding//metal ion binding//RNA binding//protein binding GO:0005783 endoplasmic reticulum KOG0674 Calreticulin Cluster-8309.36897 BP_3 4449.25 214.82 1290 91085997 XP_972384.1 1187 1.9e-127 PREDICTED: cyclin-related protein FAM58A [Tribolium castaneum]>gi|270010183|gb|EFA06631.1| hypothetical protein TcasGA2_TC009550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4QQW5 520 1.7e-51 Cyclin-related protein FAM58A OS=Rattus norvegicus GN=Fam58a PE=2 SV=1 PF02984 Cyclin, C-terminal domain GO:0006355//GO:0000079 regulation of transcription, DNA-templated//regulation of cyclin-dependent protein serine/threonine kinase activity GO:0019901 protein kinase binding GO:0005634 nucleus KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.36898 BP_3 1153.33 30.06 2141 546674950 ERL86223.1 2253 7.8e-251 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 8.08832e-112 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1690 6.2e-187 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF00390//PF03949 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain GO:0006090//GO:0006099//GO:0015976//GO:0006108//GO:0055114 pyruvate metabolic process//tricarboxylic acid cycle//carbon utilization//malate metabolic process//oxidation-reduction process GO:0004471//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.36899 BP_3 897.94 3.92 11343 642933491 XP_008197440.1 2917 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 211 2.63023e-103 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1747 8.0e-193 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF01479//PF00163 S4 domain//Ribosomal protein S4/S9 N-terminal domain GO:0008152 metabolic process GO:0003723//GO:0019843//GO:0003824 RNA binding//rRNA binding//catalytic activity GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.369 BP_3 33.00 6.23 547 321477237 EFX88196.1 609 8.6e-61 hypothetical protein DAPPUDRAFT_305566 [Daphnia pulex] 884814334 XM_013129207.1 48 4.87991e-14 PREDICTED: Melopsittacus undulatus ribosomal protein L21 (LOC101874126), transcript variant X3, mRNA K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 P46778 558 2.9e-56 60S ribosomal protein L21 OS=Homo sapiens GN=RPL21 PE=1 SV=2 PF01157 Ribosomal protein L21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.3690 BP_3 3.00 0.36 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36900 BP_3 28.09 0.64 2420 478251082 ENN71558.1 804 9.3e-83 hypothetical protein YQE_11660, partial [Dendroctonus ponderosae]>gi|546671909|gb|ERL84016.1| hypothetical protein D910_01335 [Dendroctonus ponderosae]>gi|546671968|gb|ERL84050.1| hypothetical protein D910_01379 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P04572 289 2.0e-24 Sarcoplasmic calcium-binding protein OS=Perinereis vancaurica tetradentata PE=1 SV=1 PF13833//PF10591//PF00036//PF13405//PF13499//PF12513//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain//EF-hand domain pair//Mitochondrial degradasome RNA helicase subunit C terminal//EF hand GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.36902 BP_3 1535.00 135.69 837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009 Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.36903 BP_3 631.86 98.14 602 91092830 XP_968086.1 444 1.3e-41 PREDICTED: prefoldin subunit 6 [Tribolium castaneum]>gi|270003070|gb|EEZ99517.1| hypothetical protein TcasGA2_TC000098 [Tribolium castaneum] -- -- -- -- -- K04798 pfdB, PFDN6 prefoldin beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04798 O15212 261 8.7e-22 Prefoldin subunit 6 OS=Homo sapiens GN=PFDN6 PE=1 SV=1 PF09177//PF03938//PF09036//PF02346//PF07195//PF01920//PF12009 Syntaxin 6, N-terminal//Outer membrane protein (OmpH-like)//Bcr-Abl oncoprotein oligomerisation domain//Chordopoxvirus multifunctional envelope protein A27//Flagellar hook-associated protein 2 C-terminus//Prefoldin subunit//Telomerase ribonucleoprotein complex - RNA binding domain GO:0006457//GO:0048193//GO:0019064//GO:0016310//GO:0007155//GO:0007165//GO:0006278//GO:0009069//GO:0006468 protein folding//Golgi vesicle transport//fusion of virus membrane with host plasma membrane//phosphorylation//cell adhesion//signal transduction//RNA-dependent DNA replication//serine family amino acid metabolic process//protein phosphorylation GO:0003964//GO:0005096//GO:0051082//GO:0004674 RNA-directed DNA polymerase activity//GTPase activator activity//unfolded protein binding//protein serine/threonine kinase activity GO:0019031//GO:0016020//GO:0009288//GO:0016272 viral envelope//membrane//bacterial-type flagellum//prefoldin complex KOG3478 Prefoldin subunit 6, KE2 family Cluster-8309.36904 BP_3 1275.03 52.38 1465 332376001 AEE63141.1 1215 1.2e-130 unknown [Dendroctonus ponderosae] 332376000 BT128180.1 70 8.01238e-26 Dendroctonus ponderosae clone DPO1027_P21 unknown mRNA -- -- -- -- Q5BLY5 569 4.1e-57 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.36905 BP_3 209.40 2.39 4514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219//PF03089 Insulin-like growth factor binding protein//Recombination activating protein 2 GO:0001558//GO:0006310 regulation of cell growth//DNA recombination GO:0003677//GO:0005520 DNA binding//insulin-like growth factor binding GO:0016942//GO:0005576//GO:0005634 insulin-like growth factor binding protein complex//extracellular region//nucleus -- -- Cluster-8309.36906 BP_3 207.64 2.94 3700 270016569 EFA13015.1 3331 0.0e+00 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] 831318133 XM_012836335.1 35 5.86999e-06 PREDICTED: Clupea harengus low density lipoprotein receptor-related protein 2 (lrp2), mRNA -- -- -- -- P35953 1649 6.1e-182 Very low-density lipoprotein receptor OS=Oryctolagus cuniculus GN=VLDLR PE=2 SV=1 PF00057//PF07645//PF07095//PF00002//PF06682//PF08506 Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Intracellular growth attenuator protein IgaA//7 transmembrane receptor (Secretin family)//SOCE-associated regulatory factor of calcium homoeostasis//Cse1 GO:0007186//GO:0006886//GO:2001256 G-protein coupled receptor signaling pathway//intracellular protein transport//regulation of store-operated calcium entry GO:0005509//GO:0005515//GO:0004930 calcium ion binding//protein binding//G-protein coupled receptor activity GO:0009276//GO:0016021//GO:0030176 Gram-negative-bacterium-type cell wall//integral component of membrane//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.36908 BP_3 1699.74 75.84 1372 270004078 EFA00526.1 545 5.7e-53 hypothetical protein TcasGA2_TC003391 [Tribolium castaneum] 662204498 XM_008477405.1 35 2.14264e-06 PREDICTED: Diaphorina citri uncharacterized LOC103512635 (LOC103512635), mRNA -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.36910 BP_3 1913.85 11.25 8488 270002790 EEZ99237.1 1342 1.3e-144 held out wings [Tribolium castaneum] 645014013 XM_008207131.1 223 4.19594e-110 PREDICTED: Nasonia vitripennis protein held out wings (LOC100120734), mRNA K14945 QKI protein quaking http://www.genome.jp/dbget-bin/www_bget?ko:K14945 O01367 1015 4.6e-108 Protein held out wings OS=Drosophila melanogaster GN=how PE=1 SV=1 PF13014//PF00013//PF13762 KH domain//KH domain//Mitochondrial splicing apparatus component GO:0000372 Group I intron splicing GO:0003723 RNA binding GO:0030529 intracellular ribonucleoprotein complex KOG1588 RNA-binding protein Sam68 and related KH domain proteins Cluster-8309.36912 BP_3 580.44 2.78 10358 91090496 XP_969212.1 1701 3.9e-186 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] 642935356 XM_964189.2 200 3.12804e-97 PREDICTED: Tribolium castaneum forkhead box protein P4 (LOC657747), mRNA K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 1044 2.4e-111 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF00250//PF01299//PF01546 Forkhead domain//Lysosome-associated membrane glycoprotein (Lamp)//Peptidase family M20/M25/M40 GO:0006520//GO:0006508//GO:0006355//GO:0000051//GO:0008152 cellular amino acid metabolic process//proteolysis//regulation of transcription, DNA-templated//obsolete urea cycle intermediate metabolic process//metabolic process GO:0003700//GO:0008237//GO:0043565//GO:0004046//GO:0016787 transcription factor activity, sequence-specific DNA binding//metallopeptidase activity//sequence-specific DNA binding//aminoacylase activity//hydrolase activity GO:0005737//GO:0016020//GO:0005667 cytoplasm//membrane//transcription factor complex KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.36914 BP_3 1592.00 83.65 1209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.36916 BP_3 36.00 0.74 2647 642915176 XP_008190506.1 292 2.4e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36917 BP_3 70.89 0.31 11197 642911559 XP_970343.3 4078 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 280 1.14146e-141 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 3196 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF04689//PF03808//PF00640//PF08074//PF00176//PF01874 DNA binding protein S1FA//Glycosyl transferase WecB/TagA/CpsF family//Phosphotyrosine interaction domain (PTB/PID)//CHDCT2 (NUC038) domain//SNF2 family N-terminal domain//ATP:dephospho-CoA triphosphoribosyl transferase GO:0016310//GO:0006355//GO:0009058 phosphorylation//regulation of transcription, DNA-templated//biosynthetic process GO:0005524//GO:0003677//GO:0046917//GO:0005515//GO:0008270//GO:0016818 ATP binding//DNA binding//triphosphoribosyl-dephospho-CoA synthase activity//protein binding//zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.36919 BP_3 5206.84 77.38 3535 642922924 XP_008200453.1 3883 0.0e+00 PREDICTED: cytoplasmic aconitate hydratase-like [Tribolium castaneum]>gi|270006548|gb|EFA02996.1| hypothetical protein TcasGA2_TC010417 [Tribolium castaneum] 780711820 XM_011706420.1 163 3.9248e-77 PREDICTED: Wasmannia auropunctata cytoplasmic aconitate hydratase-like (LOC105460001), transcript variant X2, mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 P28271 3137 0.0e+00 Cytoplasmic aconitate hydratase OS=Mus musculus GN=Aco1 PE=2 SV=3 PF00694//PF00330 Aconitase C-terminal domain//Aconitase family (aconitate hydratase) GO:0008152 metabolic process GO:0051539 4 iron, 4 sulfur cluster binding -- -- KOG0452 RNA-binding translational regulator IRP (aconitase superfamily) Cluster-8309.36920 BP_3 13193.62 418.85 1810 646714091 KDR18184.1 1655 1.5e-181 Guanine nucleotide-binding protein subunit beta-like protein [Zootermopsis nevadensis] 389610732 AK402355.1 291 1.39444e-148 Papilio polytes mRNA for receptor of activated protein kinase C 1, complete cds, sequence id: Pp-0111 K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1518 4.6e-167 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.36923 BP_3 92.37 1.51 3233 642912940 XP_008201316.1 816 5.0e-84 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5MGH0 543 9.4e-54 Serine protease inhibitor 3/4 (Fragment) OS=Lonomia obliqua PE=1 SV=1 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.36924 BP_3 7436.59 64.07 5886 642933803 XP_008197345.1 467 2.7e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 1.11369e-64 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36926 BP_3 875.17 114.85 659 332373744 AEE62013.1 180 5.7e-11 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36928 BP_3 183.28 2.32 4097 91084075 XP_967986.1 1341 8.5e-145 PREDICTED: regucalcin [Tribolium castaneum]>gi|270006685|gb|EFA03133.1| hypothetical protein TcasGA2_TC013045 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I923 524 1.9e-51 Regucalcin OS=Gallus gallus GN=RGN PE=2 SV=1 -- -- GO:0050790 regulation of catalytic activity GO:0005509//GO:0030234 calcium ion binding//enzyme regulator activity -- -- -- -- Cluster-8309.36929 BP_3 8734.86 172.60 2731 642926449 XP_008191964.1 1143 5.1e-122 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|642926451|ref|XP_008191965.1| PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009087|gb|EFA05535.1| hypothetical protein TcasGA2_TC015722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 538 3.0e-53 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF07992//PF05834//PF01266//PF05199//PF02254 GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0055114//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//potassium ion transport GO:0050660//GO:0016705//GO:0016614//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity -- -- -- -- Cluster-8309.3693 BP_3 29.00 0.85 1936 642917767 XP_008191359.1 1456 1.8e-158 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 721 1.3e-74 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF15015//PF00732//PF05834//PF01266//PF05199//PF07992//PF15985//PF02254 Spermatogenesis-associated, N-terminal//GMC oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//KH domain//TrkA-N domain GO:0016117//GO:0055114//GO:0007283//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//spermatogenesis//potassium ion transport GO:0050660//GO:0016705//GO:0016614//GO:0003723//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//RNA binding//oxidoreductase activity GO:0005794 Golgi apparatus -- -- Cluster-8309.36931 BP_3 190.60 1.68 5746 827549501 XP_012546855.1 643 1.0e-63 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.6e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.36932 BP_3 17.01 0.32 2864 546675851 ERL86956.1 2118 4.7e-235 hypothetical protein D910_04359 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86W56 221 1.8e-16 Poly(ADP-ribose) glycohydrolase OS=Homo sapiens GN=PARG PE=1 SV=1 PF00848//PF05028 Ring hydroxylating alpha subunit (catalytic domain)//Poly (ADP-ribose) glycohydrolase (PARG) GO:0055114//GO:0005975//GO:0019439 oxidation-reduction process//carbohydrate metabolic process//aromatic compound catabolic process GO:0005506//GO:0004649//GO:0051537//GO:0016708 iron ion binding//poly(ADP-ribose) glycohydrolase activity//2 iron, 2 sulfur cluster binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor -- -- -- -- Cluster-8309.36933 BP_3 120.80 6.14 1240 861591666 KMQ82837.1 179 1.4e-10 integrase core domain protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36934 BP_3 546.58 24.85 1352 91078888 XP_973143.1 1435 3.5e-156 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 Q9Z2A0 961 1.3e-102 3-phosphoinositide-dependent protein kinase 1 OS=Mus musculus GN=Pdpk1 PE=1 SV=2 PF07714//PF00069//PF06293//PF05445 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Poxvirus serine/threonine protein kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.36935 BP_3 34.63 0.46 3911 642936769 XP_008198572.1 840 1.0e-86 PREDICTED: general transcription factor IIF subunit 1 isoform X2 [Tribolium castaneum] 820846436 XM_012485722.1 154 4.37742e-72 PREDICTED: Apis florea general transcription factor IIF subunit 1-like (LOC100863803), mRNA K03138 TFIIF1, GTF2F1, TFG1 transcription initiation factor TFIIF subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03138 Q05913 679 1.9e-69 General transcription factor IIF subunit 1 OS=Drosophila melanogaster GN=TfIIFalpha PE=1 SV=3 PF05793//PF08202 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Mis12-Mtw1 protein family GO:0007059//GO:0006367//GO:0051301//GO:0032968 chromosome segregation//transcription initiation from RNA polymerase II promoter//cell division//positive regulation of transcription elongation from RNA polymerase II promoter GO:0003677 DNA binding GO:0000444//GO:0005634 MIS12/MIND type complex//nucleus KOG2393 Transcription initiation factor IIF, large subunit (RAP74) Cluster-8309.36937 BP_3 2225.69 27.88 4140 189236215 XP_975776.2 3673 0.0e+00 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] 820834819 XM_003689675.2 267 7.0762e-135 PREDICTED: Apis florea alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like (LOC100865289), mRNA K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 987 3.9e-105 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF02358//PF00982 Trehalose-phosphatase//Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.36938 BP_3 400.49 31.27 909 255522807 NP_001157316.1 714 9.5e-73 longitudinals lacking isoform 7 [Tribolium castaneum] 255522808 NM_001163845.1 255 7.07353e-129 Tribolium castaneum longitudinals lacking (Lola), transcript variant 8, mRNA -- -- -- -- -- -- -- -- PF00096//PF13465//PF04988 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.36939 BP_3 1.84 3.11 304 817190070 XP_012270387.1 178 4.5e-11 PREDICTED: longitudinals lacking protein, isoform G isoform X41 [Orussus abietinus] -- -- -- -- -- -- -- -- -- P28166 120 9.8e-06 Zinc finger protein 1 OS=Drosophila melanogaster GN=zfh1 PE=1 SV=2 PF03811//PF00096//PF13465 InsA N-terminal domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006313 transposition, DNA-mediated GO:0046872 metal ion binding -- -- -- -- Cluster-8309.36940 BP_3 70.07 0.97 3770 148230813 NP_001083770.1 359 5.8e-31 microtubule-associated protein 4 [Xenopus laevis]>gi|4063005|dbj|BAA36221.1| XMAP4 [Xenopus laevis] -- -- -- -- -- -- -- -- -- P12036 213 2.0e-15 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF02730 Aldehyde ferredoxin oxidoreductase, N-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0016625//GO:0051536 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//iron-sulfur cluster binding -- -- -- -- Cluster-8309.36942 BP_3 1623.64 274.27 577 91090912 XP_973979.1 703 1.1e-71 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] 642936036 XM_968886.2 165 4.71143e-79 PREDICTED: Tribolium castaneum troponin C, isoform 2 (LOC662809), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47948 618 3.4e-63 Troponin C, isoform 2 OS=Drosophila melanogaster GN=TpnC47D PE=2 SV=2 PF03528//PF13833//PF13405//PF00036//PF13499//PF13202//PF12763 Rabaptin//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0005515//GO:0005509//GO:0005096//GO:0008083 protein binding//calcium ion binding//GTPase activator activity//growth factor activity -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.36943 BP_3 23.92 0.39 3285 91084727 XP_970450.1 2622 2.0e-293 PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|642925824|ref|XP_008190453.1| PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|270008937|gb|EFA05385.1| hypothetical protein TcasGA2_TC015557 [Tribolium castaneum] 642925825 XM_965357.2 476 0 PREDICTED: Tribolium castaneum uncharacterized LOC659018 (LOC659018), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01749 Importin beta binding domain GO:0015031//GO:0006606 protein transport//protein import into nucleus GO:0008565 protein transporter activity GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.36945 BP_3 781.17 28.93 1593 91076140 XP_970221.1 1054 6.3e-112 PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|642911692|ref|XP_008200703.1| PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|642911694|ref|XP_008200704.1| PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|642911696|ref|XP_008200705.1| PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|270014714|gb|EFA11162.1| hypothetical protein TcasGA2_TC004767 [Tribolium castaneum] -- -- -- -- -- K04438 CRK, CRKII proto-oncogene C-crk http://www.genome.jp/dbget-bin/www_bget?ko:K04438 Q9XYM0 845 4.4e-89 Adapter molecule Crk OS=Drosophila melanogaster GN=Crk PE=1 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4792 Crk family adapters Cluster-8309.36946 BP_3 9809.83 102.67 4897 642933803 XP_008197345.1 467 2.2e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 9.25406e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q5KSL6 146 1.5e-07 Diacylglycerol kinase kappa OS=Homo sapiens GN=DGKK PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36947 BP_3 801.04 5.10 7865 642929711 XP_008195945.1 2542 8.8e-284 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.67276e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q60996 1954 5.5e-217 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Mus musculus GN=Ppp2r5c PE=1 SV=2 PF06068//PF05496//PF01603//PF07728//PF01695//PF07724//PF00004 TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0007165//GO:0006281 DNA recombination//signal transduction//DNA repair GO:0016887//GO:0009378//GO:0008601//GO:0005524//GO:0003678 ATPase activity//four-way junction helicase activity//protein phosphatase type 2A regulator activity//ATP binding//DNA helicase activity GO:0000159//GO:0009379//GO:0005657 protein phosphatase type 2A complex//Holliday junction helicase complex//replication fork KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.36948 BP_3 145.85 1.09 6715 642926249 XP_974073.3 1630 4.3e-178 PREDICTED: mannose-1-phosphate guanyltransferase beta [Tribolium castaneum]>gi|270009027|gb|EFA05475.1| hypothetical protein TcasGA2_TC015659 [Tribolium castaneum] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q295Y7 1534 2.4e-168 Mannose-1-phosphate guanyltransferase beta OS=Drosophila pseudoobscura pseudoobscura GN=GA10892 PE=3 SV=1 PF06459//PF09726//PF00076//PF07959//PF01128//PF09270//PF04111//PF00483//PF08671//PF02932 Ryanodine Receptor TM 4-6//Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//L-fucokinase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//Beta-trefoil DNA-binding domain//Autophagy protein Apg6//Nucleotidyl transferase//Anti-repressor SinI//Neurotransmitter-gated ion-channel transmembrane region GO:0006914//GO:0008299//GO:0006816//GO:0006694//GO:0006874//GO:0009058//GO:0006355//GO:0006811 autophagy//isoprenoid biosynthetic process//calcium ion transport//steroid biosynthetic process//cellular calcium ion homeostasis//biosynthetic process//regulation of transcription, DNA-templated//ion transport GO:0000978//GO:0016779//GO:0050518//GO:0016772//GO:0000982//GO:0046983//GO:0005219//GO:0003676 RNA polymerase II core promoter proximal region sequence-specific DNA binding//nucleotidyltransferase activity//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//transferase activity, transferring phosphorus-containing groups//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//protein dimerization activity//ryanodine-sensitive calcium-release channel activity//nucleic acid binding GO:0016021//GO:0005622//GO:0005634//GO:0016020 integral component of membrane//intracellular//nucleus//membrane KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.36949 BP_3 18723.00 1179.25 1057 91089051 XP_970069.1 1019 4.7e-108 PREDICTED: 40S ribosomal protein SA [Tribolium castaneum]>gi|270012401|gb|EFA08849.1| hypothetical protein TcasGA2_TC006550 [Tribolium castaneum] -- -- -- -- -- K02998 RP-SAe, RPSA small subunit ribosomal protein SAe http://www.genome.jp/dbget-bin/www_bget?ko:K02998 Q5UAP4 925 1.5e-98 40S ribosomal protein SA OS=Bombyx mori PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0015935//GO:0005840 intracellular//small ribosomal subunit//ribosome -- -- Cluster-8309.36950 BP_3 1816.05 18.30 5074 478250592 ENN71084.1 1150 1.5e-122 hypothetical protein YQE_12017, partial [Dendroctonus ponderosae]>gi|546672947|gb|ERL84655.1| hypothetical protein D910_02082 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GLM5 222 2.5e-16 Desumoylating isopeptidase 1 OS=Xenopus laevis GN=desi1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.36952 BP_3 257.22 3.29 4060 189240877 XP_971050.2 976 1.8e-102 PREDICTED: leucine-rich repeat flightless-interacting protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9W6 441 7.9e-42 Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus GN=LRRFIP2 PE=2 SV=1 PF00769//PF05557 Ezrin/radixin/moesin family//Mitotic checkpoint protein GO:0007094 mitotic spindle assembly checkpoint GO:0008092 cytoskeletal protein binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG2010 Double stranded RNA binding protein Cluster-8309.36955 BP_3 471.97 14.15 1899 642934430 XP_008197659.1 2383 5.8e-266 PREDICTED: mitochondrial Rho GTPase isoform X1 [Tribolium castaneum] -- -- -- -- -- K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 1696 1.1e-187 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 PF07231//PF00005//PF03193//PF00910//PF04670//PF10662//PF00071//PF02367//PF00036//PF13202//PF07475//PF01926//PF13499//PF01695//PF08477//PF00735//PF13405//PF07728//PF00025//PF00004 Hs1pro-1 N-terminus//ABC transporter//Protein of unknown function, DUF258//RNA helicase//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//EF hand//EF hand//HPr Serine kinase C-terminal domain//50S ribosome-binding GTPase//EF-hand domain pair//IstB-like ATP binding protein//Ras of Complex, Roc, domain of DAPkinase//Septin//EF-hand domain//AAA domain (dynein-related subfamily)//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA) GO:0002949//GO:0007264//GO:0006576//GO:0016310//GO:0000160//GO:0006109//GO:0006952 tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction//cellular biogenic amine metabolic process//phosphorylation//phosphorelay signal transduction system//regulation of carbohydrate metabolic process//defense response GO:0005525//GO:0005509//GO:0003724//GO:0004672//GO:0003723//GO:0016887//GO:0005524//GO:0000155//GO:0003924 GTP binding//calcium ion binding//RNA helicase activity//protein kinase activity//RNA binding//ATPase activity//ATP binding//phosphorelay sensor kinase activity//GTPase activity GO:0009365 protein histidine kinase complex KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.36957 BP_3 413.71 3.11 6694 642911053 XP_008200620.1 8548 0.0e+00 PREDICTED: HEAT repeat-containing protein 5B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2D3 5379 0.0e+00 HEAT repeat-containing protein 5B OS=Homo sapiens GN=HEATR5B PE=1 SV=2 PF00514//PF08785//PF02985 Armadillo/beta-catenin-like repeat//Ku C terminal domain like//HEAT repeat -- -- GO:0005515//GO:0016817 protein binding//hydrolase activity, acting on acid anhydrides -- -- KOG1822 Uncharacterized conserved protein Cluster-8309.36958 BP_3 287.83 2.27 6400 642928644 XP_008199718.1 1825 1.0e-200 PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZF3 1247 4.3e-135 Oxysterol-binding protein-related protein 6 OS=Homo sapiens GN=OSBPL6 PE=1 SV=1 PF03623 Focal adhesion targeting region GO:0007165//GO:0007172//GO:0006468 signal transduction//signal complex assembly//protein phosphorylation GO:0004871//GO:0004713 signal transducer activity//protein tyrosine kinase activity GO:0005925 focal adhesion -- -- Cluster-8309.36959 BP_3 91.49 0.45 10149 642934181 XP_008199641.1 2782 0.0e+00 PREDICTED: uncharacterized protein LOC657682 isoform X2 [Tribolium castaneum] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 1.8e-215 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF00130//PF04857//PF10510//PF17095//PF00183//PF00628//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//CAF1 family ribonuclease//Phosphatidylinositol-glycan biosynthesis class S protein//Spectrin-binding region of Ca2+-Calmodulin//Hsp90 protein//PHD-finger//C1-like domain GO:0031175//GO:0035556//GO:0055114//GO:0006457//GO:0006950//GO:0016255 neuron projection development//intracellular signal transduction//oxidation-reduction process//protein folding//response to stress//attachment of GPI anchor to protein GO:0051082//GO:0047134//GO:0030507//GO:0005524//GO:0005516//GO:0005515 unfolded protein binding//protein-disulfide reductase activity//spectrin binding//ATP binding//calmodulin binding//protein binding GO:0008091//GO:0042765//GO:0005634 spectrin//GPI-anchor transamidase complex//nucleus KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.36960 BP_3 80.00 3.37 1435 642938161 XP_968707.2 769 6.3e-79 PREDICTED: ras-related and estrogen-regulated growth inhibitor-like protein [Tribolium castaneum]>gi|270016488|gb|EFA12934.1| hypothetical protein TcasGA2_TC010480 [Tribolium castaneum] -- -- -- -- -- K07855 RERG Ras-related and estrogen-regulated growth inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K07855 Q0VCJ7 299 8.2e-26 Ras-related and estrogen-regulated growth inhibitor OS=Bos taurus GN=RERG PE=2 SV=1 PF00071//PF14525//PF04218//PF01926//PF08477//PF03193 Ras family//AraC-binding-like domain//CENP-B N-terminal DNA-binding domain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0006355//GO:0006184//GO:0007264 regulation of transcription, DNA-templated//obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005525//GO:0003677//GO:0003924 GTP binding//DNA binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.36962 BP_3 61.36 0.56 5617 332375705 AEE62993.1 1349 1.4e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01619 deoC, DERA deoxyribose-phosphate aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01619 Q9Y315 963 3.2e-102 Deoxyribose-phosphate aldolase OS=Homo sapiens GN=DERA PE=1 SV=2 PF00096//PF01791//PF00651 Zinc finger, C2H2 type//DeoC/LacD family aldolase//BTB/POZ domain -- -- GO:0016829//GO:0005515//GO:0046872 lyase activity//protein binding//metal ion binding -- -- KOG3981 Deoxyribose-phosphate aldolase Cluster-8309.36963 BP_3 433.72 4.65 4785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36964 BP_3 50.44 2.61 1222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01177 Asp/Glu/Hydantoin racemase GO:0006807 nitrogen compound metabolic process GO:0036361 racemase activity, acting on amino acids and derivatives -- -- -- -- Cluster-8309.36965 BP_3 138.19 0.60 11324 642925096 XP_008194167.1 3781 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum]>gi|642925098|ref|XP_008194168.1| PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum] 642925099 XM_964960.2 404 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q0JKD0 2165 2.7e-241 Glutamate synthase 1 [NADH], chloroplastic OS=Oryza sativa subsp. japonica GN=Os01g0681900 PE=2 SV=1 PF01134//PF00869//PF13241//PF05834//PF00833//PF01494//PF00287//PF07992//PF01210//PF01493//PF00070//PF04183//PF01645//PF01266//PF01593//PF12831//PF01070//PF04898//PF00743 Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains//Putative NAD(P)-binding//Lycopene cyclase protein//Ribosomal S17//FAD binding domain//Sodium / potassium ATPase beta chain//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//GXGXG motif//Pyridine nucleotide-disulphide oxidoreductase//IucA / IucC family//Conserved region in glutamate synthase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//FMN-dependent dehydrogenase//Glutamate synthase central domain//Flavin-binding monooxygenase-like GO:0008033//GO:0006826//GO:0006537//GO:0006807//GO:0006813//GO:0006412//GO:0055114//GO:0042254//GO:0006779//GO:0006814//GO:0019290//GO:0016117//GO:0008152//GO:0019354//GO:0046168 tRNA processing//iron ion transport//glutamate biosynthetic process//nitrogen compound metabolic process//potassium ion transport//translation//oxidation-reduction process//ribosome biogenesis//porphyrin-containing compound biosynthetic process//sodium ion transport//siderophore biosynthetic process//carotenoid biosynthetic process//metabolic process//siroheme biosynthetic process//glycerol-3-phosphate catabolic process GO:0016638//GO:0015343//GO:0071949//GO:0050660//GO:0051287//GO:0016705//GO:0050661//GO:0004499//GO:0003735//GO:0016616//GO:0015930//GO:0046983//GO:0016491//GO:0043115 oxidoreductase activity, acting on the CH-NH2 group of donors//siderophore transmembrane transporter activity//FAD binding//flavin adenine dinucleotide binding//NAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//NADP binding//N,N-dimethylaniline monooxygenase activity//structural constituent of ribosome//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glutamate synthase activity//protein dimerization activity//oxidoreductase activity//precorrin-2 dehydrogenase activity GO:0005840//GO:0005622//GO:0005890 ribosome//intracellular//sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.36966 BP_3 503.16 12.53 2228 642932594 XP_967443.2 1634 4.9e-179 PREDICTED: fatty-acid amide hydrolase 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6GMR7 833 1.5e-87 Fatty-acid amide hydrolase 2 OS=Homo sapiens GN=FAAH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.36967 BP_3 101.83 0.81 6328 91083737 XP_970914.1 1523 1.0e-165 PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|642924379|ref|XP_008194272.1| PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|270007890|gb|EFA04338.1| hypothetical protein TcasGA2_TC014632 [Tribolium castaneum] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 Q8QZR1 721 4.2e-74 Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1 SV=1 PF02854//PF04834//PF11095//PF08115//PF00155 MIF4G domain//Early E3 14.5 kDa protein//Gem-associated protein 7 (Gemin7)//SFI toxin family//Aminotransferase class I and II GO:0009058//GO:0009966//GO:0009405//GO:0016070 biosynthetic process//regulation of signal transduction//pathogenesis//RNA metabolic process GO:0003677//GO:0003723//GO:0005515//GO:0030170 DNA binding//RNA binding//protein binding//pyridoxal phosphate binding GO:0005576//GO:0032797//GO:0016021 extracellular region//SMN complex//integral component of membrane KOG0259 Tyrosine aminotransferase Cluster-8309.36968 BP_3 2695.66 49.97 2892 642911373 XP_008199397.1 433 1.2e-39 PREDICTED: syndecan [Tribolium castaneum] -- -- -- -- -- K16336 SDC2 syndecan 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16336 P49415 290 1.8e-24 Syndecan OS=Drosophila melanogaster GN=Sdc PE=2 SV=2 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.36970 BP_3 9555.07 434.78 1351 91078140 XP_973588.1 508 1.1e-48 PREDICTED: uncharacterized protein LOC662397 [Tribolium castaneum]>gi|270002341|gb|EEZ98788.1| hypothetical protein TcasGA2_TC001352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36971 BP_3 230.00 10.65 1333 642920981 XP_008192639.1 1121 8.9e-120 PREDICTED: LOW QUALITY PROTEIN: transforming growth factor beta regulator 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3YBR2 524 6.2e-52 Transforming growth factor beta regulator 1 OS=Homo sapiens GN=TBRG1 PE=1 SV=1 PF00909//PF05965//PF05964 Ammonium Transporter Family//F/Y rich C-terminus//F/Y-rich N-terminus GO:0015696 ammonium transport GO:0008519 ammonium transmembrane transporter activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.36972 BP_3 6597.97 36.19 9079 557798908 AHA36969.1 2603 8.6e-291 heat shock protein 70b [Leptinotarsa decemlineata] 557798907 KC544269.1 729 0 Leptinotarsa decemlineata heat shock protein 70b mRNA, complete cds K09490 HSPA5, BIP heat shock 70kDa protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09490 P29844 2503 1.4e-280 Heat shock 70 kDa protein cognate 3 OS=Drosophila melanogaster GN=Hsc70-3 PE=2 SV=2 PF00400//PF01968//PF02782//PF06723 WD domain, G-beta repeat//Hydantoinase/oxoprolinase//FGGY family of carbohydrate kinases, C-terminal domain//MreB/Mbl protein GO:0005975//GO:0000902 carbohydrate metabolic process//cell morphogenesis GO:0005515//GO:0016787//GO:0016773 protein binding//hydrolase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG0100 Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily Cluster-8309.36975 BP_3 287.95 3.79 3954 642921063 XP_008192676.1 518 2.2e-49 PREDICTED: LIM domain transcription factor LMO4.2-like isoform X1 [Tribolium castaneum] 642921066 XM_008194456.1 283 8.616e-144 PREDICTED: Tribolium castaneum LIM domain only protein 3-like (LOC663863), transcript variant X3, mRNA -- -- -- -- Q99MB5 396 1.3e-36 LIM domain only protein 3 OS=Rattus norvegicus GN=Lmo3 PE=2 SV=2 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36976 BP_3 20.28 0.32 3366 642933145 XP_008197275.1 2062 1.7e-228 PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum]>gi|642933147|ref|XP_008197277.1| PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum] 642933146 XM_008199055.1 284 2.03605e-144 PREDICTED: Tribolium castaneum extracellular serine/threonine protein kinase FAM20C (LOC662687), transcript variant X2, mRNA -- -- -- -- A4VCL2 1487 3.4e-163 Extracellular serine/threonine protein CG31145 OS=Drosophila melanogaster GN=CG31145 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3829 Uncharacterized conserved protein Cluster-8309.36979 BP_3 5212.70 65.92 4103 642910240 XP_008198519.1 1641 1.4e-179 PREDICTED: glycogenin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 P13280 927 3.5e-98 Glycogenin-1 OS=Oryctolagus cuniculus GN=GYG1 PE=1 SV=3 PF01501//PF11051//PF08988 Glycosyl transferase family 8//Mannosyltransferase putative//Type III secretion system, cytoplasmic E component of needle GO:0009405//GO:0006486 pathogenesis//protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.36980 BP_3 18.05 0.38 2583 478262445 ENN81116.1 688 2.8e-69 hypothetical protein YQE_02484, partial [Dendroctonus ponderosae]>gi|546673666|gb|ERL85230.1| hypothetical protein D910_02651 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q08C69 422 8.0e-40 RNA pseudouridylate synthase domain-containing protein 1 OS=Danio rerio GN=rpusd1 PE=2 SV=1 PF00849 RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG1919 RNA pseudouridylate synthases Cluster-8309.36981 BP_3 9238.95 198.33 2537 91086995 XP_973636.1 1879 2.2e-207 PREDICTED: protein krasavietz [Tribolium castaneum] 642929327 XM_968543.2 536 0 PREDICTED: Tribolium castaneum protein krasavietz (LOC662449), mRNA -- -- -- -- Q9VNE2 1321 4.5e-144 Protein krasavietz OS=Drosophila melanogaster GN=kra PE=1 SV=1 PF02020 eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515 protein binding -- -- KOG2297 Predicted translation factor, contains W2 domain Cluster-8309.36982 BP_3 935.97 27.62 1925 478253032 ENN73412.1 234 9.2e-17 hypothetical protein YQE_09974, partial [Dendroctonus ponderosae] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q965X6 208 3.9e-15 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis elegans GN=siah-1 PE=1 SV=3 PF15965//PF05195//PF02176//PF03145 TRAF-like zinc-finger//Aminopeptidase P, N-terminal domain//TRAF-type zinc finger//Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0004177//GO:0008270//GO:0030145 aminopeptidase activity//zinc ion binding//manganese ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.36985 BP_3 25.83 0.85 1755 91080645 XP_974525.1 1505 3.5e-164 PREDICTED: KIF1-binding protein homolog [Tribolium castaneum]>gi|270005501|gb|EFA01949.1| hypothetical protein TcasGA2_TC007564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZIL9 739 9.5e-77 KIF1-binding protein homolog OS=Gallus gallus GN=kbp PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36986 BP_3 15675.54 344.64 2484 478263722 ENN82025.1 960 7.7e-101 hypothetical protein YQE_01600, partial [Dendroctonus ponderosae] 769857176 XM_011641913.1 177 4.53359e-85 PREDICTED: Pogonomyrmex barbatus 40S ribosomal protein S23 (LOC105429139), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q6EV23 747 1.6e-77 40S ribosomal protein S23 OS=Papilio dardanus GN=RpS23 PE=2 SV=1 PF09445//PF00164 RNA cap guanine-N2 methyltransferase//Ribosomal protein S12/S23 GO:0009452//GO:0001510//GO:0006412//GO:0042254 7-methylguanosine RNA capping//RNA methylation//translation//ribosome biogenesis GO:0003735//GO:0008168 structural constituent of ribosome//methyltransferase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1749 40S ribosomal protein S23 Cluster-8309.36987 BP_3 2295.08 37.61 3233 288899098 ADC67081.1 2704 6.0e-303 proline dehydrogenase isoform 1 [Leptinotarsa decemlineata] 170047825 XM_001851357.1 257 1.99666e-129 Culex quinquefasciatus proline oxidase, mRNA K00318 PRODH proline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00318 Q04499 2131 6.8e-238 Proline dehydrogenase 1, mitochondrial OS=Drosophila melanogaster GN=slgA PE=1 SV=2 PF05139 Erythromycin esterase GO:0046677 response to antibiotic -- -- -- -- KOG0186 Proline oxidase Cluster-8309.36988 BP_3 19069.93 184.23 5281 642923500 XP_008193535.1 431 3.6e-39 PREDICTED: flocculation protein FLO11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36990 BP_3 80.25 1.68 2596 642938577 XP_008199848.1 2080 1.1e-230 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938579|ref|XP_008199849.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938581|ref|XP_008199850.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938583|ref|XP_008199851.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938585|ref|XP_008199852.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|270015602|gb|EFA12050.1| hypothetical protein TcasGA2_TC001467 [Tribolium castaneum] 642938584 XM_008201630.1 540 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X5, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 Q16720 1398 5.4e-153 Plasma membrane calcium-transporting ATPase 3 OS=Homo sapiens GN=ATP2B3 PE=1 SV=3 PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006754//GO:0006816//GO:0070588 ATP biosynthetic process//calcium ion transport//calcium ion transmembrane transport GO:0005388//GO:0046872//GO:0005524 calcium-transporting ATPase activity//metal ion binding//ATP binding GO:0016529//GO:0016021 sarcoplasmic reticulum//integral component of membrane KOG0204 Calcium transporting ATPase Cluster-8309.36993 BP_3 661.15 5.49 6099 189236215 XP_975776.2 2722 9.2e-305 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] 820834819 XM_003689675.2 267 1.04539e-134 PREDICTED: Apis florea alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like (LOC100865289), mRNA K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 921 2.6e-97 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF02358//PF00982 Trehalose-phosphatase//Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.36995 BP_3 4141.41 91.18 2481 91078870 XP_972519.1 2161 4.2e-240 PREDICTED: peptide transporter family 1-like [Tribolium castaneum] 462304202 APGK01049574.1 91 2.90433e-37 Dendroctonus ponderosae Seq01049584, whole genome shotgun sequence K14206 SLC15A1, PEPT1 solute carrier family 15 (oligopeptide transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14206 P91679 1396 8.8e-153 Peptide transporter family 1 OS=Drosophila melanogaster GN=yin PE=1 SV=2 PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1237 H+/oligopeptide symporter Cluster-8309.36999 BP_3 79.47 2.63 1746 749750480 XP_011137500.1 342 2.5e-29 PREDICTED: myosin light chain alkali isoform X1 [Harpegnathos saltator] -- -- -- -- -- K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 311 4.0e-27 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13499//PF13405 EF-hand domain pair//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.37002 BP_3 10391.24 120.24 4457 642933803 XP_008197345.1 467 2.0e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 8.41641e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q9CZG3 131 7.7e-06 COMM domain-containing protein 8 OS=Mus musculus GN=Commd8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37003 BP_3 87.85 2.30 2135 270006980 EFA03428.1 2188 2.7e-243 hypothetical protein TcasGA2_TC013417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFY8 790 1.4e-82 Tripartite motif-containing protein 45 OS=Mus musculus GN=Trim45 PE=2 SV=2 PF00643//PF14634//PF00097//PF13639 B-box zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005622 intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.37004 BP_3 15368.45 895.42 1119 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37005 BP_3 265.75 1.44 9215 642924084 XP_008193999.1 5676 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X1 [Tribolium castaneum] 642924089 XM_008195780.1 741 0 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 12 (LOC656353), transcript variant X4, mRNA K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q86YW9 2448 3.4e-274 Mediator of RNA polymerase II transcription subunit 12-like protein OS=Homo sapiens GN=MED12L PE=1 SV=2 PF03260//PF09497 Lepidopteran low molecular weight (30 kD) lipoprotein//Transcription mediator complex subunit Med12 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005576 mediator complex//extracellular region KOG3598 Thyroid hormone receptor-associated protein complex, subunit TRAP230 Cluster-8309.37006 BP_3 139.61 11.32 886 546683852 ERL93605.1 545 3.6e-53 hypothetical protein D910_10893 [Dendroctonus ponderosae] -- -- -- -- -- K02956 RP-S15, MRPS15, rpsO small subunit ribosomal protein S15 http://www.genome.jp/dbget-bin/www_bget?ko:K02956 Q8WTC1 479 6.8e-47 28S ribosomal protein S15, mitochondrial OS=Drosophila melanogaster GN=bonsai PE=2 SV=2 PF02881//PF05531 SRP54-type protein, helical bundle domain//Nucleopolyhedrovirus P10 protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding GO:0019028 viral capsid -- -- Cluster-8309.37007 BP_3 889.97 4.11 10721 242018392 XP_002429661.1 599 2.4e-58 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9EQB9 575 6.1e-57 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF00096//PF01155//PF12937//PF13465//PF09174//PF04810//PF00412//PF13912//PF01363//PF14972//PF00646//PF16622//PF00320 Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//F-box-like//Zinc-finger double domain//Maf1 regulator//Sec23/Sec24 zinc finger//LIM domain//C2H2-type zinc finger//FYVE zinc finger//Mitochondrial morphogenesis regulator//F-box domain//zinc-finger C2H2-type//GATA zinc finger GO:0006886//GO:0016480//GO:0006888//GO:0006464//GO:0007005//GO:0006355 intracellular protein transport//negative regulation of transcription from RNA polymerase III promoter//ER to Golgi vesicle-mediated transport//cellular protein modification process//mitochondrion organization//regulation of transcription, DNA-templated GO:0016151//GO:0005515//GO:0003700//GO:0046872//GO:0008270//GO:0043565 nickel cation binding//protein binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0031305//GO:0030127 transcription factor complex//integral component of mitochondrial inner membrane//COPII vesicle coat -- -- Cluster-8309.37009 BP_3 3185.00 62.88 2733 727098906 AIY54297.1 1092 4.2e-116 beta-tubulin C [Colaphellus bowringi] 389610986 AK402482.1 52 1.5322e-15 Papilio polytes mRNA for conserved hypothetical protein, complete cds, sequence id: Pp-0317 -- -- -- -- Q3SZE9 536 5.1e-53 Tubulin-specific chaperone C OS=Bos taurus GN=TBCC PE=2 SV=1 PF04718//PF00377//PF16752 Mitochondrial ATP synthase g subunit//Prion/Doppel alpha-helical domain//Tubulin-specific chaperone C N-terminal domain GO:0051260//GO:0015986//GO:0015992 protein homooligomerization//ATP synthesis coupled proton transport//proton transport GO:0015631//GO:0015078 tubulin binding//hydrogen ion transmembrane transporter activity GO:0045298//GO:0016020//GO:0000276 tubulin complex//membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2512 Beta-tubulin folding cofactor C Cluster-8309.37010 BP_3 16255.39 290.69 2987 642911657 XP_001810552.2 2387 3.2e-266 PREDICTED: double-stranded RNA-binding protein Staufen homolog 2 isoform X3 [Tribolium castaneum] 642911656 XM_001810500.2 174 2.54084e-83 PREDICTED: Tribolium castaneum staufen (LOC657623), transcript variant X3, mRNA K17597 STAU double-stranded RNA-binding protein Staufen http://www.genome.jp/dbget-bin/www_bget?ko:K17597 Q7ZW47 792 1.2e-82 Double-stranded RNA-binding protein Staufen homolog 2 OS=Danio rerio GN=stau2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3732 Staufen and related double-stranded-RNA-binding proteins Cluster-8309.37012 BP_3 392.99 9.55 2275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37013 BP_3 78.61 0.46 8470 478254915 ENN75149.1 2582 2.2e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.76433e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.7e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF08465//PF00665//PF13683//PF01534//PF01392 Thymidine kinase from Herpesvirus C-terminal//Integrase core domain//Integrase core domain//Frizzled/Smoothened family membrane region//Fz domain GO:0006206//GO:0015074//GO:0007166//GO:0006230 pyrimidine nucleobase metabolic process//DNA integration//cell surface receptor signaling pathway//TMP biosynthetic process GO:0005524//GO:0004797//GO:0005515 ATP binding//thymidine kinase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.37014 BP_3 233.96 8.71 1587 546686197 ERL95577.1 364 6.4e-32 hypothetical protein D910_12838 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08586 RSC complex, Rsc14/Ldb7 subunit GO:0043044 ATP-dependent chromatin remodeling -- -- GO:0016586 RSC complex -- -- Cluster-8309.37015 BP_3 44.01 2.53 1130 91086561 XP_975997.1 378 1.1e-33 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X1 [Tribolium castaneum]>gi|270009775|gb|EFA06223.1| hypothetical protein TcasGA2_TC009072 [Tribolium castaneum] -- -- -- -- -- K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 233 2.9e-18 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094//GO:0006099 gluconeogenesis//tricarboxylic acid cycle GO:0004611//GO:0004613//GO:0005525 phosphoenolpyruvate carboxykinase activity//phosphoenolpyruvate carboxykinase (GTP) activity//GTP binding -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37018 BP_3 221.10 3.22 3599 91085875 XP_966911.1 1172 2.9e-125 PREDICTED: pentatricopeptide repeat-containing protein 2, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ55 357 3.9e-32 Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus GN=PTCD2 PE=2 SV=1 PF11380//PF04750//PF05049 Stealth protein CR2, conserved region 2//FAR-17a/AIG1-like protein//Interferon-inducible GTPase (IIGP) -- -- GO:0005525//GO:0016772 GTP binding//transferase activity, transferring phosphorus-containing groups GO:0016020//GO:0016021 membrane//integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.37020 BP_3 19.60 11.36 372 332374310 AEE62296.1 180 3.2e-11 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37021 BP_3 3055.94 45.29 3544 189236215 XP_975776.2 3726 0.0e+00 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] 820834819 XM_003689675.2 267 6.04856e-135 PREDICTED: Apis florea alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like (LOC100865289), mRNA K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 987 3.4e-105 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF02358//PF00982 Trehalose-phosphatase//Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.37022 BP_3 14891.00 215.32 3625 642932423 XP_008197105.1 699 2.1e-70 PREDICTED: uncharacterized protein LOC103314057 [Tribolium castaneum]>gi|270011584|gb|EFA08032.1| hypothetical protein TcasGA2_TC005621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37023 BP_3 424.26 16.09 1563 546677249 ERL88118.1 1370 1.4e-148 hypothetical protein D910_05507 [Dendroctonus ponderosae] 642931316 XM_008198307.1 358 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 1045 2.8e-112 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0003774//GO:0005524 motor activity//ATP binding GO:0016459 myosin complex -- -- Cluster-8309.37024 BP_3 2434.66 203.28 869 264667459 ACY71315.1 524 9.8e-51 ribosomal protein L28 [Chrysomela tremula] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 427 7.1e-41 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-8309.37025 BP_3 745.20 12.10 3261 91089929 XP_973045.1 210 9.5e-14 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168//PF02935 Triple QxxK/R motif-containing protein family//Cytochrome c oxidase subunit VIIc GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005789//GO:0045277 endoplasmic reticulum membrane//respiratory chain complex IV -- -- Cluster-8309.37026 BP_3 1065.94 36.74 1690 478250933 ENN71418.1 1948 1.4e-215 hypothetical protein YQE_11922, partial [Dendroctonus ponderosae] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q6B855 1593 8.6e-176 Transketolase OS=Bos taurus GN=TKT PE=2 SV=1 PF13292//PF02775//PF00676 1-deoxy-D-xylulose-5-phosphate synthase//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Dehydrogenase E1 component GO:0006694//GO:0016114//GO:0008152 steroid biosynthetic process//terpenoid biosynthetic process//metabolic process GO:0030976//GO:0008661//GO:0016624//GO:0003824 thiamine pyrophosphate binding//1-deoxy-D-xylulose-5-phosphate synthase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity -- -- KOG0523 Transketolase Cluster-8309.37029 BP_3 139.09 1.43 4967 546683557 ERL93355.1 4599 0.0e+00 hypothetical protein D910_10647, partial [Dendroctonus ponderosae] -- -- -- -- -- K10521 ABTB2 ankyrin repeat and BTB/POZ domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10521 Q7TQI7 1604 1.3e-176 Ankyrin repeat and BTB/POZ domain-containing protein 2 OS=Mus musculus GN=Abtb2 PE=2 SV=1 PF13606//PF00651//PF00023//PF01466 Ankyrin repeat//BTB/POZ domain//Ankyrin repeat//Skp1 family, dimerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- -- -- Cluster-8309.37031 BP_3 17812.06 187.93 4860 642931268 XP_008196506.1 3052 0.0e+00 PREDICTED: myosin heavy chain, muscle isoform X1 [Tribolium castaneum]>gi|642931270|ref|XP_008196507.1| PREDICTED: myosin heavy chain, muscle isoform X1 [Tribolium castaneum] 642931316 XM_008198307.1 1525 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2869 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00038//PF00769//PF01576//PF09177 Intermediate filament protein//Ezrin/radixin/moesin family//Myosin tail//Syntaxin 6, N-terminal GO:0048193 Golgi vesicle transport GO:0003774//GO:0008092//GO:0005198 motor activity//cytoskeletal protein binding//structural molecule activity GO:0016020//GO:0005737//GO:0016459//GO:0019898//GO:0005882 membrane//cytoplasm//myosin complex//extrinsic component of membrane//intermediate filament -- -- Cluster-8309.37032 BP_3 10.82 0.76 982 546680237 ERL90555.1 690 6.2e-70 hypothetical protein D910_07903 [Dendroctonus ponderosae] 332373055 BT126707.1 106 5.16512e-46 Dendroctonus ponderosae clone DPO131_P13 unknown mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47947 433 1.6e-41 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF13202//PF12763//PF13833//PF13405//PF00036//PF13499 EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.37033 BP_3 2557.96 179.14 980 646701257 KDR11062.1 615 3.1e-61 ATP synthase subunit beta, mitochondrial [Zootermopsis nevadensis] 170040304 XM_001847892.1 228 7.81154e-114 Culex quinquefasciatus ATP synthase beta subunit, mRNA K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q05825 581 1.1e-58 ATP synthase subunit beta, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-beta PE=1 SV=3 PF00306 ATP synthase alpha/beta chain, C terminal domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-8309.37036 BP_3 108.75 1.15 4838 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1125 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF03144//PF00983//PF01926 Elongation factor G, domain IV//Elongation factor Tu domain 2//Tymovirus coat protein//50S ribosome-binding GTPase -- -- GO:0005198//GO:0005525 structural molecule activity//GTP binding GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.37037 BP_3 8138.68 101.83 4144 642933491 XP_008197440.1 2917 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 257 2.56562e-129 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1747 2.9e-193 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain GO:0008152 metabolic process GO:0003723//GO:0003824//GO:0019843 RNA binding//catalytic activity//rRNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.37039 BP_3 125.57 7.22 1130 270016484 EFA12930.1 300 1.2e-24 hypothetical protein TcasGA2_TC010476 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35554 173 2.6e-11 Flightin OS=Drosophila melanogaster GN=fln PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37040 BP_3 54.00 0.72 3921 642928001 XP_008195479.1 1414 2.8e-153 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] -- -- -- -- -- K07377 NRXN neurexin http://www.genome.jp/dbget-bin/www_bget?ko:K07377 Q9Y4C0 532 2.1e-52 Neurexin-3 OS=Homo sapiens GN=NRXN3 PE=1 SV=4 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.37041 BP_3 167.98 44.60 473 401871116 AFQ23943.1 142 1.0e-06 Kunitz-like protease inhibitor [Pomacea canaliculata] -- -- -- -- -- -- -- -- -- O54819 139 9.6e-08 Tissue factor pathway inhibitor OS=Mus musculus GN=Tfpi PE=2 SV=1 PF00014//PF07127 Kunitz/Bovine pancreatic trypsin inhibitor domain//Late nodulin protein GO:0009878 nodule morphogenesis GO:0004867//GO:0046872 serine-type endopeptidase inhibitor activity//metal ion binding -- -- -- -- Cluster-8309.37045 BP_3 359.00 4.35 4271 642912316 XP_969236.2 2536 2.4e-283 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BZW8 1281 3.3e-139 NHL repeat-containing protein 2 OS=Mus musculus GN=Nhlrc2 PE=2 SV=1 PF01731//PF00085//PF01436 Arylesterase//Thioredoxin//NHL repeat GO:0045454 cell redox homeostasis GO:0004064//GO:0005515 arylesterase activity//protein binding -- -- -- -- Cluster-8309.37047 BP_3 48.76 0.92 2835 58294539 AAW70172.1 2594 3.0e-290 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 972 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 1798 2.5e-199 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.37048 BP_3 790.00 16.00 2672 270006004 EFA02452.1 1564 7.6e-171 hypothetical protein TcasGA2_TC008139 [Tribolium castaneum] 642920079 XM_001815999.2 143 3.88203e-66 PREDICTED: Tribolium castaneum uncharacterized LOC100142030 (LOC100142030), mRNA -- -- -- -- Q497V6 513 2.3e-50 Bromo adjacent homology domain-containing 1 protein OS=Mus musculus GN=Bahd1 PE=2 SV=1 PF01426//PF00608 BAH domain//Adenoviral fibre protein (repeat/shaft region) GO:0009405//GO:0019062//GO:0007155 pathogenesis//virion attachment to host cell//cell adhesion GO:0003682 chromatin binding GO:0000785 chromatin KOG1886 BAH domain proteins Cluster-8309.37050 BP_3 7208.85 282.89 1520 478250717 ENN71209.1 632 5.1e-63 hypothetical protein YQE_12138, partial [Dendroctonus ponderosae]>gi|546678600|gb|ERL89182.1| hypothetical protein D910_06556 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P86383 169 1.0e-10 Lysozyme OS=Meretrix lusoria PE=1 SV=1 PF05497 Destabilase GO:0005975 carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-8309.37052 BP_3 813.00 134.05 584 270004992 EFA01440.1 344 4.9e-30 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 306 5.1e-27 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF15952 Enhancer of split M4 family GO:0007423//GO:0007219 sensory organ development//Notch signaling pathway -- -- -- -- -- -- Cluster-8309.37053 BP_3 1.00 5.19 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37054 BP_3 133.41 0.52 12717 642918534 XP_008191512.1 3762 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.60655e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1207 3.7e-130 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF05461//PF13895 Apolipoprotein L//Immunoglobulin domain GO:0042157//GO:0006869 lipoprotein metabolic process//lipid transport GO:0008289//GO:0005515 lipid binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.37056 BP_3 101.75 0.95 5437 642932670 XP_008196939.1 401 1.1e-35 PREDICTED: BAG domain-containing protein Samui isoform X2 [Tribolium castaneum] -- -- -- -- -- K09558 BAG4 BCL2-associated athanogene 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09558 Q9BLJ6 306 4.8e-26 BAG domain-containing protein Samui OS=Bombyx mori GN=Samui PE=2 SV=1 PF02179//PF09198 BAG domain//Bacteriophage T4 beta-glucosyltransferase GO:0006304 DNA modification GO:0051087//GO:0033821 chaperone binding//DNA beta-glucosyltransferase activity -- -- -- -- Cluster-8309.37058 BP_3 1354.00 100.67 940 91078958 XP_974220.1 587 5.2e-58 PREDICTED: cathepsin B [Tribolium castaneum]>gi|642916227|ref|XP_008190938.1| PREDICTED: cathepsin B [Tribolium castaneum]>gi|270004841|gb|EFA01289.1| cathepsin B precursor [Tribolium castaneum] 803278454 XM_012143513.1 58 2.37932e-19 PREDICTED: Ovis aries musimon cathepsin B (CTSB), transcript variant X4, mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 Q4R5M2 482 3.2e-47 Cathepsin B OS=Macaca fascicularis GN=CTSB PE=2 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37059 BP_3 1640.01 14.62 5699 642931308 XP_008196526.1 2541 8.4e-284 PREDICTED: myosin heavy chain, muscle isoform X22 [Tribolium castaneum] 642931316 XM_008198307.1 805 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2245 7.2e-251 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF08001//PF02419//PF05060//PF02736//PF00063 CMV US//PsbL protein//N-acetylglucosaminyltransferase II (MGAT2)//Myosin N-terminal SH3-like domain//Myosin head (motor domain) GO:0015979//GO:0009312//GO:0030683 photosynthesis//oligosaccharide biosynthetic process//evasion or tolerance by virus of host immune response GO:0005524//GO:0008455//GO:0003774 ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity//motor activity GO:0016021//GO:0016459//GO:0016020//GO:0005795//GO:0044386//GO:0009539//GO:0009523 integral component of membrane//myosin complex//membrane//Golgi stack//integral to host endoplasmic reticulum membrane//photosystem II reaction center//photosystem II KOG0161 Myosin class II heavy chain Cluster-8309.37060 BP_3 14622.68 128.02 5797 642931284 XP_008196514.1 3465 0.0e+00 PREDICTED: myosin heavy chain, muscle isoform X8 [Tribolium castaneum] 642931316 XM_008198307.1 1081 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 3056 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF05060//PF02736//PF00063//PF08001 N-acetylglucosaminyltransferase II (MGAT2)//Myosin N-terminal SH3-like domain//Myosin head (motor domain)//CMV US GO:0030683//GO:0009312 evasion or tolerance by virus of host immune response//oligosaccharide biosynthetic process GO:0003774//GO:0005524//GO:0008455 motor activity//ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GO:0005795//GO:0044386//GO:0016021//GO:0016459 Golgi stack//integral to host endoplasmic reticulum membrane//integral component of membrane//myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.37061 BP_3 1225.97 9.56 6474 478257766 ENN77909.1 2079 3.5e-230 hypothetical protein YQE_05586, partial [Dendroctonus ponderosae] -- -- -- -- -- K19030 PFKFB4 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K19030 Q91348 901 5.8e-95 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Gallus gallus PE=2 SV=2 PF01591//PF07728//PF01583//PF00910//PF07967//PF00005//PF05485//PF06414 6-phosphofructo-2-kinase//AAA domain (dynein-related subfamily)//Adenylylsulphate kinase//RNA helicase//C3HC zinc finger-like//ABC transporter//THAP domain//Zeta toxin GO:0000103//GO:0006144//GO:0006000//GO:0006013 sulfate assimilation//purine nucleobase metabolic process//fructose metabolic process//mannose metabolic process GO:0003723//GO:0005524//GO:0004020//GO:0003873//GO:0016887//GO:0016301//GO:0003676//GO:0008270//GO:0003724 RNA binding//ATP binding//adenylylsulfate kinase activity//6-phosphofructo-2-kinase activity//ATPase activity//kinase activity//nucleic acid binding//zinc ion binding//RNA helicase activity GO:0005634 nucleus KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.37062 BP_3 873.85 14.93 3112 642925507 XP_008194579.1 1692 1.3e-185 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.75603e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 P47820 1164 8.8e-126 Angiotensin-converting enzyme OS=Rattus norvegicus GN=Ace PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.37063 BP_3 5016.44 42.25 6014 91081899 XP_976020.1 1589 2.2e-173 PREDICTED: cyclin-Y-like protein 1 [Tribolium castaneum]>gi|270007331|gb|EFA03779.1| hypothetical protein TcasGA2_TC013890 [Tribolium castaneum] 620962625 XM_007667839.1 113 4.18097e-49 PREDICTED: Ornithorhynchus anatinus cyclin Y (CCNY), mRNA K07881 RAB14 Ras-related protein Rab-14 http://www.genome.jp/dbget-bin/www_bget?ko:K07881 Q6NRF4 988 4.4e-105 Cyclin-Y-like protein 1-B OS=Xenopus laevis GN=ccnyl1-b PE=2 SV=1 PF03193//PF01428//PF00071//PF04670//PF08613//PF01926//PF00735//PF08477//PF00025 Protein of unknown function, DUF258//AN1-like Zinc finger//Ras family//Gtr1/RagA G protein conserved region//Cyclin//50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family GO:0000079//GO:0007264 regulation of cyclin-dependent protein serine/threonine kinase activity//small GTPase mediated signal transduction GO:0003924//GO:0019901//GO:0008270//GO:0005525 GTPase activity//protein kinase binding//zinc ion binding//GTP binding -- -- KOG1675 Predicted cyclin Cluster-8309.37064 BP_3 3073.75 13.34 11401 642925080 XP_008194161.1 4665 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A1 [Tribolium castaneum] 573902448 XM_006638886.1 156 9.92081e-73 PREDICTED: Lepisosteus oculatus lysine-specific demethylase 6A-like (LOC102692642), transcript variant X4, mRNA K14950 ATP13A1 cation-transporting ATPase 13A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14950 Q9HD20 3312 0.0e+00 Manganese-transporting ATPase 13A1 OS=Homo sapiens GN=ATP13A1 PE=1 SV=2 PF13414//PF02388//PF00122//PF03938//PF00782//PF00515//PF13949//PF00102//PF08797//PF13181 TPR repeat//FemAB family//E1-E2 ATPase//Outer membrane protein (OmpH-like)//Dual specificity phosphatase, catalytic domain//Tetratricopeptide repeat//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//HIRAN domain//Tetratricopeptide repeat GO:0006570//GO:0006470//GO:0009252 tyrosine metabolic process//protein dephosphorylation//peptidoglycan biosynthetic process GO:0008138//GO:0005515//GO:0004725//GO:0016755//GO:0016818//GO:0046872//GO:0000166//GO:0008270//GO:0051082//GO:0003676 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//transferase activity, transferring amino-acyl groups//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//metal ion binding//nucleotide binding//zinc ion binding//unfolded protein binding//nucleic acid binding -- -- KOG0209 P-type ATPase Cluster-8309.37065 BP_3 48.99 5.39 730 264667371 ACY71271.1 744 2.5e-76 ribosomal protein S19 [Chrysomela tremula] -- -- -- -- -- K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 P39018 541 3.6e-54 40S ribosomal protein S19a OS=Drosophila melanogaster GN=RpS19a PE=1 SV=3 PF01090 Ribosomal protein S19e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.37066 BP_3 2878.97 28.70 5126 546677329 ERL88186.1 1874 1.7e-206 hypothetical protein D910_05574 [Dendroctonus ponderosae] -- -- -- -- -- K17407 MRPS28 small subunit ribosomal protein S28 http://www.genome.jp/dbget-bin/www_bget?ko:K17407 Q9CY16 207 1.4e-14 28S ribosomal protein S28, mitochondrial OS=Mus musculus GN=Mrps28 PE=1 SV=1 PF06788 Uncharacterised protein family (UPF0257) -- -- -- -- GO:0005886 plasma membrane KOG4078 Putative mitochondrial ribosomal protein mRpS35 Cluster-8309.37067 BP_3 216.99 4.23 2762 642911657 XP_001810552.2 2390 1.3e-266 PREDICTED: double-stranded RNA-binding protein Staufen homolog 2 isoform X3 [Tribolium castaneum] 642911656 XM_001810500.2 174 2.34711e-83 PREDICTED: Tribolium castaneum staufen (LOC657623), transcript variant X3, mRNA K17597 STAU double-stranded RNA-binding protein Staufen http://www.genome.jp/dbget-bin/www_bget?ko:K17597 Q7ZW47 792 1.1e-82 Double-stranded RNA-binding protein Staufen homolog 2 OS=Danio rerio GN=stau2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3732 Staufen and related double-stranded-RNA-binding proteins Cluster-8309.37068 BP_3 8482.78 57.71 7376 478255753 ENN75962.1 7220 0.0e+00 hypothetical protein YQE_07496, partial [Dendroctonus ponderosae]>gi|546683628|gb|ERL93416.1| hypothetical protein D910_10708 [Dendroctonus ponderosae] 462326123 APGK01041549.1 824 0 Dendroctonus ponderosae Seq01041559, whole genome shotgun sequence K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 6044 0.0e+00 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF08471//PF01576//PF00063//PF00612 Class II vitamin B12-dependent ribonucleotide reductase//Myosin tail//Myosin head (motor domain)//IQ calmodulin-binding motif GO:0006206//GO:0055114//GO:0009186//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process GO:0003774//GO:0050897//GO:0005524//GO:0004748//GO:0005515 motor activity//cobalt ion binding//ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//protein binding GO:0016459//GO:0005971 myosin complex//ribonucleoside-diphosphate reductase complex KOG0161 Myosin class II heavy chain Cluster-8309.37069 BP_3 15176.77 357.48 2338 91078140 XP_973588.1 930 2.2e-97 PREDICTED: uncharacterized protein LOC662397 [Tribolium castaneum]>gi|270002341|gb|EEZ98788.1| hypothetical protein TcasGA2_TC001352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P87053 135 1.4e-06 F-box/WD repeat-containing protein pof1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pof1 PE=1 SV=1 PF00400//PF06516 WD domain, G-beta repeat//Purine nucleoside permease (NUP) GO:0055085 transmembrane transport GO:0005515 protein binding -- -- -- -- Cluster-8309.37070 BP_3 3.00 0.32 742 817011233 AKF11870.1 605 3.4e-60 putative juvenile hormone epoxide hydrolase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K10719 JHEH juvenile hormone epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K10719 Q8MZR6 507 3.2e-50 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.37071 BP_3 798.00 35.84 1365 546676821 ERL87767.1 952 3.6e-100 hypothetical protein D910_05156 [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VSL3 564 1.5e-56 Pyrimidodiazepine synthase OS=Drosophila melanogaster GN=se PE=1 SV=1 PF13417//PF00462//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0005515//GO:0009055//GO:0015035 protein binding//electron carrier activity//protein disulfide oxidoreductase activity -- -- KOG0406 Glutathione S-transferase Cluster-8309.37073 BP_3 2525.33 10.96 11393 270003480 EEZ99927.1 5528 0.0e+00 hypothetical protein TcasGA2_TC002723 [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 726 2.0e-74 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 PF03554//PF03110//PF03547 UL73 viral envelope glycoprotein//SBP domain//Membrane transport protein GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0019031//GO:0016021//GO:0005634 viral envelope//integral component of membrane//nucleus KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.37074 BP_3 14.21 0.34 2324 91089397 XP_974004.1 1305 7.2e-141 PREDICTED: pyridoxal-dependent decarboxylase domain-containing protein 1 [Tribolium castaneum]>gi|270011423|gb|EFA07871.1| hypothetical protein TcasGA2_TC005445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DF78 502 3.8e-49 Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Xenopus laevis GN=pdxdc1 PE=2 SV=1 PF01212//PF00282 Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain GO:0006520//GO:0019752 cellular amino acid metabolic process//carboxylic acid metabolic process GO:0030170//GO:0016829//GO:0016831 pyridoxal phosphate binding//lyase activity//carboxy-lyase activity -- -- KOG0630 Predicted pyridoxal-dependent decarboxylase Cluster-8309.37075 BP_3 69.56 9.15 658 270011903 EFA08351.1 810 5.1e-84 hypothetical protein TcasGA2_TC005994 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O18016 140 1.0e-07 Ig-like and fibronectin type-III domain-containing protein T04A11.3 OS=Caenorhabditis elegans GN=T04A11.3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37077 BP_3 177.65 0.46 18769 612342210 AHW99830.1 21219 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1873 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 17872 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00520//PF06459//PF00487//PF06423//PF05372//PF01365//PF03348//PF00622//PF13499//PF13833//PF05366//PF02815 Ion transport protein//Ryanodine Receptor TM 4-6//Fatty acid desaturase//GWT1//Delta lysin family//RIH domain//Serine incorporator (Serinc)//SPRY domain//EF-hand domain pair//EF-hand domain pair//Sarcolipin//MIR domain GO:0006629//GO:0006506//GO:0019836//GO:0006811//GO:0055085//GO:0006816//GO:0070588//GO:0006874 lipid metabolic process//GPI anchor biosynthetic process//hemolysis by symbiont of host erythrocytes//ion transport//transmembrane transport//calcium ion transport//calcium ion transmembrane transport//cellular calcium ion homeostasis GO:0005262//GO:0005515//GO:0005219//GO:0016746//GO:0005509//GO:0005216//GO:0030234 calcium channel activity//protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium ion binding//ion channel activity//enzyme regulator activity GO:0005789//GO:0016020//GO:0005576//GO:0016021//GO:0005622 endoplasmic reticulum membrane//membrane//extracellular region//integral component of membrane//intracellular KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.37079 BP_3 322.43 2.98 5510 642921981 XP_008192968.1 2946 0.0e+00 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N0W4 891 7.1e-94 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF07859//PF06330 alpha/beta hydrolase fold//Trichodiene synthase (TRI5) GO:0016114//GO:0016106//GO:0008152 terpenoid biosynthetic process//sesquiterpenoid biosynthetic process//metabolic process GO:0045482//GO:0016787 trichodiene synthase activity//hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.37081 BP_3 579.93 11.86 2649 478260541 ENN80244.1 472 3.2e-44 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911792 XM_008202523.1 94 6.67121e-39 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X2, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q12974 311 6.1e-27 Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens GN=PTP4A2 PE=1 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.37082 BP_3 207.02 6.05 1942 91076522 XP_973518.1 1440 1.3e-156 PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|642912580|ref|XP_008200918.1| PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|270002610|gb|EEZ99057.1| hypothetical protein TcasGA2_TC004932 [Tribolium castaneum] 669193686 KF516645.1 38 6.56868e-08 Paracyclopina nana programmed cell death protein 4 mRNA, partial cds K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 606 2.8e-61 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.37083 BP_3 1235.34 23.73 2801 546681841 ERL91856.1 1742 1.8e-191 hypothetical protein D910_09181 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q15582 494 3.9e-48 Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens GN=TGFBI PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.37084 BP_3 8247.80 124.73 3479 805752828 XP_012154051.1 3879 0.0e+00 PREDICTED: alpha-actinin, sarcomeric isoform X2 [Megachile rotundata] 755976945 XM_011309818.1 777 0 PREDICTED: Fopius arisanus alpha-actinin, sarcomeric (LOC105269505), transcript variant X2, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q7PKQ5 3744 0.0e+00 Alpha-actinin, sarcomeric OS=Anopheles gambiae GN=Actn PE=3 SV=2 PF00307//PF13202//PF13499//PF13833//PF13405//PF00036//PF00435 Calponin homology (CH) domain//EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Spectrin repeat -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.37086 BP_3 1043.64 15.78 3479 642929255 XP_008195756.1 2075 5.5e-230 PREDICTED: PX domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270009666|gb|EFA06114.1| hypothetical protein TcasGA2_TC008957 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q7Z7A4 1138 1.0e-122 PX domain-containing protein kinase-like protein OS=Homo sapiens GN=PXK PE=1 SV=1 PF07714//PF00787//PF02569//PF00069//PF02285//PF02205 Protein tyrosine kinase//PX domain//Pantoate-beta-alanine ligase//Protein kinase domain//Cytochrome oxidase c subunit VIII//WH2 motif GO:0019482//GO:0015992//GO:0007154//GO:0006123//GO:0015940//GO:0006468 beta-alanine metabolic process//proton transport//cell communication//mitochondrial electron transport, cytochrome c to oxygen//pantothenate biosynthetic process//protein phosphorylation GO:0004592//GO:0004129//GO:0004672//GO:0005524//GO:0003779//GO:0035091 pantoate-beta-alanine ligase activity//cytochrome-c oxidase activity//protein kinase activity//ATP binding//actin binding//phosphatidylinositol binding GO:0045277 respiratory chain complex IV KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.37088 BP_3 85.52 4.91 1132 270016479 EFA12925.1 219 3.0e-15 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00690 128 4.3e-06 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3709 BP_3 2.00 0.39 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37090 BP_3 1619.63 11.23 7243 478257467 ENN77623.1 2412 9.7e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 795110653 XM_012026968.1 101 2.36071e-42 PREDICTED: Vollenhovia emeryi alpha-protein kinase 1 (LOC105570040), transcript variant X5, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 3.3e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF00097//PF00408//PF14634//PF16672//PF00076//PF02880//PF13639//PF02879//PF02878 Zinc finger, C3HC4 type (RING finger)//Phosphoglucomutase/phosphomannomutase, C-terminal domain//zinc-RING finger domain//Ragulator complex protein LAMTOR5//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Ring finger domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0019079//GO:0071704//GO:0043066//GO:0043154//GO:0005975 viral genome replication//organic substance metabolic process//negative regulation of apoptotic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//carbohydrate metabolic process GO:0005515//GO:0008270//GO:0003676//GO:0016868//GO:0046872 protein binding//zinc ion binding//nucleic acid binding//intramolecular transferase activity, phosphotransferases//metal ion binding GO:0071986//GO:0005737 Ragulator complex//cytoplasm KOG0625 Phosphoglucomutase Cluster-8309.37091 BP_3 5351.18 34.22 7829 478249702 ENN70210.1 2311 5.4e-257 hypothetical protein YQE_12996, partial [Dendroctonus ponderosae] 768412858 XM_011570222.1 40 2.07353e-08 PREDICTED: Plutella xylostella titin (LOC105398171), mRNA -- -- -- -- Q8IIG7 171 3.1e-10 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF17123//PF02984//PF00312 RING-like zinc finger//Cyclin, C-terminal domain//Ribosomal protein S15 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0008270//GO:0005515 structural constituent of ribosome//zinc ion binding//protein binding GO:0005840//GO:0005622//GO:0005634 ribosome//intracellular//nucleus -- -- Cluster-8309.37093 BP_3 2066.77 51.03 2244 91085211 XP_972225.1 1563 8.4e-171 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009079|gb|EFA05527.1| hypothetical protein TcasGA2_TC015714 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 951 3.2e-101 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00070//PF05199//PF02254//PF07992//PF05834//PF00732//PF01266 Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0006813//GO:0055114//GO:0016117 potassium ion transport//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016614//GO:0016705 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.37094 BP_3 574.48 37.61 1028 478256915 ENN77084.1 414 6.6e-38 hypothetical protein YQE_06419, partial [Dendroctonus ponderosae] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37095 BP_3 14862.79 269.79 2947 642916360 XP_008190988.1 1937 4.7e-214 PREDICTED: protein disulfide-isomerase [Tribolium castaneum]>gi|270004199|gb|EFA00647.1| hypothetical protein TcasGA2_TC003523 [Tribolium castaneum] 358443111 JF777457.1 59 2.12421e-19 Heliconius erato control protein HCTL033 mRNA, partial cds K09580 PDIA1, P4HB protein disulfide-isomerase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K09580 P54399 1542 1.2e-169 Protein disulfide-isomerase OS=Drosophila melanogaster GN=Pdi PE=2 SV=1 PF00085//PF08534//PF01216//PF00578//PF00854//PF07912 Thioredoxin//Redoxin//Calsequestrin//AhpC/TSA family//POT family//ERp29, N-terminal domain GO:0055114//GO:0006118//GO:0009306//GO:0006810//GO:0006662//GO:0045454 oxidation-reduction process//obsolete electron transport//protein secretion//transport//glycerol ether metabolic process//cell redox homeostasis GO:0016209//GO:0009055//GO:0005509//GO:0015035//GO:0016853//GO:0005215//GO:0016491 antioxidant activity//electron carrier activity//calcium ion binding//protein disulfide oxidoreductase activity//isomerase activity//transporter activity//oxidoreductase activity GO:0016020//GO:0005783//GO:0005788 membrane//endoplasmic reticulum//endoplasmic reticulum lumen KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.37096 BP_3 23.52 1.10 1326 546683025 ERL92891.1 171 1.3e-09 hypothetical protein D910_10196 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.37098 BP_3 129.12 1.03 6360 270007552 EFA04000.1 1548 1.3e-168 hypothetical protein TcasGA2_TC014149 [Tribolium castaneum] 642922772 XM_008195097.1 443 0 PREDICTED: Tribolium castaneum protein muscleblind (LOC100142119), mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 771 6.7e-80 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF06733//PF00642//PF03176 DEAD_2//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//MMPL family -- -- GO:0046872//GO:0005524//GO:0004003//GO:0003677 metal ion binding//ATP binding//ATP-dependent DNA helicase activity//DNA binding GO:0005657//GO:0016020 replication fork//membrane KOG2494 C3H1-type Zn-finger protein Cluster-8309.371 BP_3 29.00 0.45 3413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37100 BP_3 77.65 0.88 4560 270013525 EFA09973.1 4390 0.0e+00 hypothetical protein TcasGA2_TC012131 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P10351 3893 0.0e+00 Xanthine dehydrogenase OS=Drosophila melanogaster GN=ry PE=2 SV=2 PF00111//PF01799//PF00941//PF02738 2Fe-2S iron-sulfur cluster binding domain//[2Fe-2S] binding domain//FAD binding domain in molybdopterin dehydrogenase//Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0046872//GO:0016491//GO:0009055//GO:0051536 metal ion binding//oxidoreductase activity//electron carrier activity//iron-sulfur cluster binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.37101 BP_3 425.28 6.28 3554 642923250 XP_008193676.1 4549 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 438 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 2061 9.8e-230 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF13606//PF14634//PF00023//PF00569//PF06701 Ankyrin repeat//zinc-RING finger domain//Ankyrin repeat//Zinc finger, ZZ type//Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.37102 BP_3 27.69 0.50 2949 642935906 XP_008198223.1 2248 4.1e-250 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 645001298 XM_008211242.1 690 0 PREDICTED: Nasonia vitripennis calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC100113791), transcript variant X6, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2098 4.2e-234 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF09264//PF00122 Vibrio cholerae sialidase, lectin insertion//E1-E2 ATPase -- -- GO:0000166//GO:0046872//GO:0033691 nucleotide binding//metal ion binding//sialic acid binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.37103 BP_3 33.38 3.49 753 642932344 XP_008197074.1 168 1.6e-09 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37104 BP_3 3478.84 16.74 10307 91088831 XP_970461.1 3072 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X1 [Tribolium castaneum]>gi|270012333|gb|EFA08781.1| hypothetical protein TcasGA2_TC006471 [Tribolium castaneum] 645001221 XM_001601899.3 112 2.58257e-48 PREDICTED: Nasonia vitripennis 60S ribosomal protein L34-like (LOC100113629), mRNA K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O88813 1719 1.3e-189 Long-chain-fatty-acid--CoA ligase 5 OS=Rattus norvegicus GN=Acsl5 PE=1 SV=1 PF01434//PF02601//PF16053//PF01363//PF07168//PF05008//PF00501//PF01199 Peptidase family M41//Exonuclease VII, large subunit//Mitochondrial 28S ribosomal protein S34//FYVE zinc finger//Ureide permease//Vesicle transport v-SNARE protein N-terminus//AMP-binding enzyme//Ribosomal protein L34e GO:0042254//GO:0006886//GO:0006308//GO:0006508//GO:0006412//GO:0008152//GO:0071705 ribosome biogenesis//intracellular protein transport//DNA catabolic process//proteolysis//translation//metabolic process//nitrogen compound transport GO:0003735//GO:0004222//GO:0005524//GO:0046872//GO:0008855//GO:0003824 structural constituent of ribosome//metalloendopeptidase activity//ATP binding//metal ion binding//exodeoxyribonuclease VII activity//catalytic activity GO:0005739//GO:0005840//GO:0009318//GO:0005622//GO:0016020 mitochondrion//ribosome//exodeoxyribonuclease VII complex//intracellular//membrane KOG1256 Long-chain acyl-CoA synthetases (AMP-forming) Cluster-8309.37106 BP_3 1020.90 8.18 6309 189236266 XP_974475.2 971 1.0e-101 PREDICTED: transmembrane protein 53 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ULP2 147 1.5e-07 Aftiphilin OS=Homo sapiens GN=AFTPH PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37107 BP_3 147.22 2.04 3766 91076374 XP_967954.1 2668 1.0e-298 PREDICTED: DNA ligase 3 [Tribolium castaneum]>gi|270002897|gb|EEZ99344.1| ligase III [Tribolium castaneum] -- -- -- -- -- K10776 LIG3 DNA ligase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10776 P49916 2068 1.6e-230 DNA ligase 3 OS=Homo sapiens GN=LIG3 PE=1 SV=2 PF04679//PF04675//PF00645//PF02229//PF01068 ATP dependent DNA ligase C terminal region//DNA ligase N terminus//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Transcriptional Coactivator p15 (PC4)//ATP dependent DNA ligase domain GO:0006355//GO:0006310//GO:0006260//GO:0006281 regulation of transcription, DNA-templated//DNA recombination//DNA replication//DNA repair GO:0003910//GO:0008270//GO:0000166//GO:0043167//GO:0003909//GO:0003713//GO:0005524//GO:0003677 DNA ligase (ATP) activity//zinc ion binding//nucleotide binding//ion binding//DNA ligase activity//transcription coactivator activity//ATP binding//DNA binding GO:0005667 transcription factor complex KOG0967 ATP-dependent DNA ligase I Cluster-8309.37108 BP_3 102.68 0.63 8144 642938560 XP_008199842.1 3438 0.0e+00 PREDICTED: catenin delta-2 isoform X2 [Tribolium castaneum]>gi|642938562|ref|XP_008199843.1| PREDICTED: catenin delta-2 isoform X2 [Tribolium castaneum]>gi|642938564|ref|XP_968711.3| PREDICTED: catenin delta-2 isoform X2 [Tribolium castaneum]>gi|270015599|gb|EFA12047.1| hypothetical protein TcasGA2_TC001464 [Tribolium castaneum] 642938558 XR_511746.1 659 0 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X3, misc_RNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 6.7e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF02985//PF08935//PF00514//PF09258//PF01602 HEAT repeat//Viral protein VP4 subunit//Armadillo/beta-catenin-like repeat//Glycosyl transferase family 64 domain//Adaptin N terminal region GO:0015012//GO:0006024//GO:0006886//GO:0016192 heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process//intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117//GO:0016021//GO:0019030 membrane coat//integral component of membrane//icosahedral viral capsid KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins Cluster-8309.37109 BP_3 1240.04 9.07 6885 642934807 XP_008197818.1 2312 3.6e-257 PREDICTED: ninein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2I6 514 4.6e-50 Ninein-like protein OS=Homo sapiens GN=NINL PE=1 SV=2 PF10473//PF05837//PF15070//PF04479//PF13405//PF13499//PF04977//PF00170 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centromere protein H (CENP-H)//Putative golgin subfamily A member 2-like protein 5//RTA1 like protein//EF-hand domain//EF-hand domain pair//Septum formation initiator//bZIP transcription factor GO:0007049//GO:0006355//GO:0051382//GO:0006950 cell cycle//regulation of transcription, DNA-templated//kinetochore assembly//response to stress GO:0003700//GO:0043565//GO:0042803//GO:0005509//GO:0045502//GO:0008134 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein homodimerization activity//calcium ion binding//dynein binding//transcription factor binding GO:0000776//GO:0005794//GO:0005667//GO:0030286//GO:0016021 kinetochore//Golgi apparatus//transcription factor complex//dynein complex//integral component of membrane KOG0161 Myosin class II heavy chain Cluster-8309.37111 BP_3 475.15 16.30 1697 242010990 XP_002426240.1 1041 2.1e-110 tubulin beta-1 chain [Pediculus humanus corporis]>gi|212510303|gb|EEB13502.1| tubulin beta-1 chain [Pediculus humanus corporis] 164683615 EU373305.1 686 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q27U48 1040 1.2e-111 Tubulin beta-1 chain OS=Glossina morsitans morsitans PE=2 SV=1 -- -- GO:0006184//GO:0051258//GO:0007018 obsolete GTP catabolic process//protein polymerization//microtubule-based movement GO:0005525//GO:0005198//GO:0003924 GTP binding//structural molecule activity//GTPase activity GO:0005737//GO:0005874 cytoplasm//microtubule KOG1375 Beta tubulin Cluster-8309.37112 BP_3 1729.31 34.06 2739 546676745 ERL87701.1 384 5.3e-34 hypothetical protein D910_05091 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 131 4.7e-06 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37114 BP_3 35.23 1.71 1283 91092056 XP_970271.1 785 7.8e-81 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] -- -- -- -- -- K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 631 2.3e-64 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF01180//PF02527//PF00977//PF01884 Dihydroorotate dehydrogenase//rRNA small subunit methyltransferase G//Histidine biosynthesis protein//PcrB family GO:0006364//GO:0006206//GO:0055114//GO:0000154//GO:0000105//GO:0006396//GO:0055086//GO:0072528 rRNA processing//pyrimidine nucleobase metabolic process//oxidation-reduction process//rRNA modification//histidine biosynthetic process//RNA processing//nucleobase-containing small molecule metabolic process//pyrimidine-containing compound biosynthetic process GO:0004152//GO:0016627//GO:0016765//GO:0008649 dihydroorotate dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//transferase activity, transferring alkyl or aryl (other than methyl) groups//rRNA methyltransferase activity GO:0005737 cytoplasm KOG1799 Dihydropyrimidine dehydrogenase Cluster-8309.37116 BP_3 3137.00 57.14 2938 189238490 XP_001809098.1 1279 9.4e-138 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|642926357|ref|XP_008194892.1| PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08799 136 1.3e-06 Myosin-2 heavy chain OS=Dictyostelium discoideum GN=mhcA PE=1 SV=3 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain GO:0043039 tRNA aminoacylation GO:0005524//GO:0016876 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds -- -- -- -- Cluster-8309.37118 BP_3 157.37 4.94 1828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37120 BP_3 76.00 15.90 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05001 RNA polymerase Rpb1 C-terminal repeat GO:0006366 transcription from RNA polymerase II promoter GO:0003677 DNA binding GO:0005665 DNA-directed RNA polymerase II, core complex -- -- Cluster-8309.37121 BP_3 942.67 12.07 4057 642923252 XP_008193678.1 4686 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 390178834 XM_001359343.3 125 6.00194e-56 Drosophila pseudoobscura pseudoobscura GA18295 (Dpse\GA18295), partial mRNA K01191 E3.2.1.24 alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01191 Q8BRK9 1596 9.3e-176 Alpha-mannosidase 2x OS=Mus musculus GN=Man2a2 PE=2 SV=2 PF01074//PF07748//PF09261 Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain//Alpha mannosidase, middle domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0004553//GO:0008270//GO:0015923//GO:0004559 hydrolase activity, hydrolyzing O-glycosyl compounds//zinc ion binding//mannosidase activity//alpha-mannosidase activity -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.37123 BP_3 619.28 15.06 2274 642924570 XP_008194348.1 691 1.1e-69 PREDICTED: probable signal peptidase complex subunit 2 [Tribolium castaneum]>gi|270006751|gb|EFA03199.1| hypothetical protein TcasGA2_TC013119 [Tribolium castaneum] -- -- -- -- -- K12947 SPCS2, SPC2 signal peptidase complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12947 Q28250 519 4.0e-51 Signal peptidase complex subunit 2 OS=Canis familiaris GN=SPCS2 PE=1 SV=1 PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.37124 BP_3 5590.63 25.59 10820 642935792 XP_008198176.1 2065 2.5e-228 PREDICTED: nitric oxide synthase, salivary gland isoform X2 [Tribolium castaneum] 817198904 XM_012419693.1 44 1.7148e-10 PREDICTED: Orussus abietinus nitric oxide synthase, salivary gland (LOC105696887), transcript variant X5, mRNA K13240 NOS1 nitric-oxide synthase, brain http://www.genome.jp/dbget-bin/www_bget?ko:K13240 Q26240 1634 9.7e-180 Nitric oxide synthase, salivary gland OS=Rhodnius prolixus PE=2 SV=1 PF01040//PF00802//PF00175//PF04103//PF00335//PF09570//PF00667 UbiA prenyltransferase family//Pneumovirus attachment glycoprotein G//Oxidoreductase NAD-binding domain//CD20-like family//Tetraspanin family//SinI restriction endonuclease//FAD binding domain GO:0009307//GO:0055114//GO:0006308 DNA restriction-modification system//oxidation-reduction process//DNA catabolic process GO:0004659//GO:0009036//GO:0003677//GO:0016491 prenyltransferase activity//Type II site-specific deoxyribonuclease activity//DNA binding//oxidoreductase activity GO:0016021//GO:0055036//GO:0009359 integral component of membrane//virion membrane//Type II site-specific deoxyribonuclease complex KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.37125 BP_3 4982.85 32.60 7658 91084647 XP_966816.1 2888 0.0e+00 PREDICTED: carboxypeptidase D [Tribolium castaneum] 332374583 BT127471.1 238 1.73572e-118 Dendroctonus ponderosae clone DPO102_A24 unknown mRNA K07752 CPD carboxypeptidase D http://www.genome.jp/dbget-bin/www_bget?ko:K07752 P42787 2075 5.0e-231 Carboxypeptidase D OS=Drosophila melanogaster GN=svr PE=1 SV=2 PF00246//PF13499//PF13405//PF10591//PF13833//PF12763//PF08038//PF00036//PF01694//PF04952//PF13202 Zinc carboxypeptidase//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//TOM7 family//EF hand//Rhomboid family//Succinylglutamate desuccinylase / Aspartoacylase family//EF hand GO:0006508//GO:0030150//GO:0008152//GO:0007165 proteolysis//protein import into mitochondrial matrix//metabolic process//signal transduction GO:0004181//GO:0004252//GO:0005509//GO:0008270//GO:0005515//GO:0016788 metallocarboxypeptidase activity//serine-type endopeptidase activity//calcium ion binding//zinc ion binding//protein binding//hydrolase activity, acting on ester bonds GO:0005742//GO:0005578//GO:0016021 mitochondrial outer membrane translocase complex//proteinaceous extracellular matrix//integral component of membrane KOG2649 Zinc carboxypeptidase Cluster-8309.37126 BP_3 520.92 6.90 3930 642918236 XP_008191424.1 2733 3.1e-306 PREDICTED: uncharacterized protein LOC658718 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.30346e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00168//PF00130 C2 domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.37127 BP_3 7882.67 192.93 2261 270007221 EFA03669.1 298 4.1e-24 hypothetical protein TcasGA2_TC013767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.37128 BP_3 2364.55 6.78 17093 270010741 EFA07189.1 5021 0.0e+00 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] 407731599 JQ771517.1 1604 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF13895//PF05986//PF08686//PF00122//PF02714//PF02480//PF00014//PF04545 Immunoglobulin domain//ADAM-TS Spacer 1//PLAC (protease and lacunin) domain//E1-E2 ATPase//Calcium-dependent channel, 7TM region, putative phosphate//Alphaherpesvirus glycoprotein E//Kunitz/Bovine pancreatic trypsin inhibitor domain//Sigma-70, region 4 GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0016987//GO:0000166//GO:0046872//GO:0003700//GO:0008233//GO:0003677//GO:0004222//GO:0005515//GO:0004867 sigma factor activity//nucleotide binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//peptidase activity//DNA binding//metalloendopeptidase activity//protein binding//serine-type endopeptidase inhibitor activity GO:0016020//GO:0031012//GO:0005667 membrane//extracellular matrix//transcription factor complex KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.37132 BP_3 446.04 5.16 4457 649572227 NP_001280512.1 6286 0.0e+00 clathrin heavy chain [Tribolium castaneum]>gi|270008499|gb|EFA04947.1| hypothetical protein TcasGA2_TC015014 [Tribolium castaneum]>gi|629511285|gb|AHY84716.1| clathrin heavy chain [Tribolium castaneum] 347969081 XM_003436308.1 1771 0 Anopheles gambiae str. PEST AGAP003021-PB (AgaP_AGAP003021) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 5737 0.0e+00 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF00231//PF01736//PF00637//PF04053//PF12937//PF13176//PF02806//PF00515//PF09268 ATP synthase//Polyomavirus agnoprotein//Region in Clathrin and VPS//Coatomer WD associated region//F-box-like//Tetratricopeptide repeat//Alpha amylase, C-terminal all-beta domain//Tetratricopeptide repeat//Clathrin, heavy-chain linker GO:0015992//GO:0005975//GO:0016192//GO:0006886//GO:0015986//GO:0006119 proton transport//carbohydrate metabolic process//vesicle-mediated transport//intracellular protein transport//ATP synthesis coupled proton transport//oxidative phosphorylation GO:0046933//GO:0046961//GO:0005198//GO:0043169//GO:0005515//GO:0003824//GO:0003677 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//structural molecule activity//cation binding//protein binding//catalytic activity//DNA binding GO:0030130//GO:0045259//GO:0030132//GO:0030117//GO:0045261 clathrin coat of trans-Golgi network vesicle//proton-transporting ATP synthase complex//clathrin coat of coated pit//membrane coat//proton-transporting ATP synthase complex, catalytic core F(1) KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.37133 BP_3 3258.71 147.72 1355 478257348 ENN77508.1 887 1.2e-92 hypothetical protein YQE_06034, partial [Dendroctonus ponderosae] -- -- -- -- -- K02127 ATPeF0B, ATP5F1, ATP4 F-type H+-transporting ATPase subunit b http://www.genome.jp/dbget-bin/www_bget?ko:K02127 Q94516 667 1.6e-68 ATP synthase subunit b, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-b PE=2 SV=2 PF05405 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG3976 Mitochondrial F1F0-ATP synthase, subunit b/ATP4 Cluster-8309.37134 BP_3 6320.17 63.09 5120 58294539 AAW70172.1 3429 0.0e+00 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 1244 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 2319 1.7e-259 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.37135 BP_3 280.54 3.41 4256 642923836 XP_008193900.1 2211 1.2e-245 PREDICTED: LOW QUALITY PROTEIN: DNA repair protein complementing XP-G cells homolog [Tribolium castaneum] -- -- -- -- -- K10846 ERCC5, XPG, RAD2 DNA excision repair protein ERCC-5 http://www.genome.jp/dbget-bin/www_bget?ko:K10846 P28715 625 3.8e-63 DNA repair protein complementing XP-G cells OS=Homo sapiens GN=ERCC5 PE=1 SV=3 PF00752//PF03592//PF00867 XPG N-terminal domain//Terminase small subunit//XPG I-region GO:0006281//GO:0006323 DNA repair//DNA packaging GO:0004518 nuclease activity -- -- KOG2520 5'-3' exonuclease Cluster-8309.37136 BP_3 499.81 3.59 7006 546671490 ERL83783.1 805 2.1e-82 hypothetical protein D910_01021 [Dendroctonus ponderosae]>gi|546686735|gb|ERL95825.1| hypothetical protein D910_00390 [Dendroctonus ponderosae] 665817572 XM_008559342.1 66 6.52997e-23 PREDICTED: Microplitis demolitor iron-sulfur cluster assembly 1 homolog, mitochondrial (LOC103578320), partial mRNA K13628 iscA, ISCA1 iron-sulfur cluster assembly protein http://www.genome.jp/dbget-bin/www_bget?ko:K13628 Q4QRC6 514 4.7e-50 Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Danio rerio GN=isca1 PE=2 SV=1 PF12317//PF07882 Intraflagellar transport complex B protein 46 C terminal//L-fucose isomerase, second N-terminal domain GO:0006004//GO:0006000//GO:0042073//GO:0006013 fucose metabolic process//fructose metabolic process//intraciliary transport//mannose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm KOG1120 Fe-S cluster biosynthesis protein ISA1 (contains a HesB-like domain) Cluster-8309.37137 BP_3 33.73 0.63 2891 642931618 XP_008196658.1 1801 2.7e-198 PREDICTED: 6-phosphofructokinase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 1616 3.2e-178 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006098//GO:0006096//GO:0006012//GO:0006094//GO:0006013//GO:0006000 pentose-phosphate shunt//glycolytic process//galactose metabolic process//gluconeogenesis//mannose metabolic process//fructose metabolic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.37138 BP_3 1019.97 8.93 5799 642922249 XP_008193077.1 3756 0.0e+00 PREDICTED: sodium bicarbonate cotransporter 3 isoform X1 [Tribolium castaneum]>gi|642922251|ref|XP_008193078.1| PREDICTED: sodium bicarbonate cotransporter 3 isoform X1 [Tribolium castaneum]>gi|642922253|ref|XP_008193079.1| PREDICTED: sodium bicarbonate cotransporter 3 isoform X1 [Tribolium castaneum] 642922254 XM_008194859.1 405 0 PREDICTED: Tribolium castaneum sodium bicarbonate cotransporter 3 (LOC661759), transcript variant X4, mRNA -- -- -- -- Q32LP4 2317 3.3e-259 Sodium-driven chloride bicarbonate exchanger OS=Bos taurus GN=SLC4A10 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.37139 BP_3 5787.90 24.14 11850 546679384 ERL89859.1 3289 0.0e+00 hypothetical protein D910_07218, partial [Dendroctonus ponderosae] 532092872 XM_005332061.1 187 6.03353e-90 PREDICTED: Spermophilus tridecemlineatus lysine (K)-specific demethylase 4B (Kdm4b), mRNA K06709 KDM4, JMJD2, JHDM3 jumonji domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06709 Q9V6L0 1585 5.1e-174 Probable lysine-specific demethylase 4B OS=Drosophila melanogaster GN=Kdm4B PE=3 SV=3 PF02102//PF00240//PF05033//PF00856//PF09280//PF14560//PF01299//PF01429 Deuterolysin metalloprotease (M35) family//Ubiquitin family//Pre-SET motif//SET domain//XPC-binding domain//Ubiquitin-like domain//Lysosome-associated membrane glycoprotein (Lamp)//Methyl-CpG binding domain GO:0034968//GO:0006281//GO:0006508//GO:0006479//GO:0006289//GO:0006554//GO:0043161 histone lysine methylation//DNA repair//proteolysis//protein methylation//nucleotide-excision repair//lysine catabolic process//proteasome-mediated ubiquitin-dependent protein catabolic process GO:0004222//GO:0003677//GO:0018024//GO:0005515//GO:0008270//GO:0003684 metalloendopeptidase activity//DNA binding//histone-lysine N-methyltransferase activity//protein binding//zinc ion binding//damaged DNA binding GO:0005634//GO:0016020 nucleus//membrane KOG0958 DNA damage-responsive repressor GIS1/RPH1, jumonji superfamily Cluster-8309.37140 BP_3 118.44 0.53 11109 546675647 ERL86797.1 2468 4.8e-275 hypothetical protein D910_04202 [Dendroctonus ponderosae] 170039960 XM_001847732.1 64 1.34202e-21 Culex quinquefasciatus phosphatidylinositol 3-kinase 1, mRNA K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 O35904 1433 2.0e-156 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus GN=Pik3cd PE=1 SV=2 PF00454//PF02888//PF01189//PF00951//PF01728//PF01135//PF09446 Phosphatidylinositol 3- and 4-kinase//Calmodulin binding domain//16S rRNA methyltransferase RsmF//Arterivirus GL envelope glycoprotein//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//VMA21-like domain GO:0046500//GO:0032259//GO:0006479//GO:0006813//GO:0070072//GO:0006464 S-adenosylmethionine metabolic process//methylation//protein methylation//potassium ion transport//vacuolar proton-transporting V-type ATPase complex assembly//cellular protein modification process GO:0004719//GO:0016773//GO:0008168//GO:0015269//GO:0005516 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//phosphotransferase activity, alcohol group as acceptor//methyltransferase activity//calcium-activated potassium channel activity//calmodulin binding GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-8309.37141 BP_3 1132.21 5.75 9775 546675647 ERL86797.1 3344 0.0e+00 hypothetical protein D910_04202 [Dendroctonus ponderosae] 170039960 XM_001847732.1 106 5.30069e-45 Culex quinquefasciatus phosphatidylinositol 3-kinase 1, mRNA K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 O35904 2100 8.1e-234 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus GN=Pik3cd PE=1 SV=2 PF09446//PF01728//PF01135//PF00951//PF00454//PF02888//PF01189 VMA21-like domain//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Arterivirus GL envelope glycoprotein//Phosphatidylinositol 3- and 4-kinase//Calmodulin binding domain//16S rRNA methyltransferase RsmF GO:0032259//GO:0046500//GO:0006479//GO:0006813//GO:0070072//GO:0006464 methylation//S-adenosylmethionine metabolic process//protein methylation//potassium ion transport//vacuolar proton-transporting V-type ATPase complex assembly//cellular protein modification process GO:0016773//GO:0008168//GO:0004719//GO:0015269//GO:0005516 phosphotransferase activity, alcohol group as acceptor//methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//calcium-activated potassium channel activity//calmodulin binding GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110) Cluster-8309.37142 BP_3 65.44 2.47 1568 332376242 AEE63261.1 479 2.9e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VCG3 407 2.7e-38 Putative OPA3-like protein CG13603 OS=Drosophila melanogaster GN=CG13601 PE=2 SV=1 PF02827 cAMP-dependent protein kinase inhibitor GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862 cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex KOG3335 Predicted coiled-coil protein Cluster-8309.37143 BP_3 467.34 26.28 1149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37144 BP_3 40.19 0.36 5649 91075930 XP_967309.1 1180 5.4e-126 PREDICTED: congested-like trachea protein [Tribolium castaneum]>gi|270014645|gb|EFA11093.1| hypothetical protein TcasGA2_TC004690 [Tribolium castaneum] 642939201 XM_008202158.1 245 1.64256e-122 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA K15109 SLC25A20_29, CACT, CACL, CRC1 solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter), member 20/29 http://www.genome.jp/dbget-bin/www_bget?ko:K15109 Q9VQG4 882 8.0e-93 Congested-like trachea protein OS=Drosophila melanogaster GN=colt PE=2 SV=1 PF03547//PF02617 Membrane transport protein//ATP-dependent Clp protease adaptor protein ClpS GO:0030163//GO:0055085 protein catabolic process//transmembrane transport -- -- GO:0016021 integral component of membrane KOG0758 Mitochondrial carnitine-acylcarnitine carrier protein Cluster-8309.37148 BP_3 290.00 1.32 10854 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q914H5 203 8.4e-14 Putative transmembrane protein 57 OS=Sulfolobus islandicus filamentous virus (isolate Iceland/Hveragerdi) GN=SIFV0057 PE=4 SV=1 PF00376//PF05965//PF03307 MerR family regulatory protein//F/Y rich C-terminus//Adenovirus 15.3kD protein in E3 region GO:0006355//GO:0019049 regulation of transcription, DNA-templated//evasion or tolerance of host defenses by virus GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.37149 BP_3 4295.45 33.54 6465 91088689 XP_974981.1 866 1.6e-89 PREDICTED: protein phosphatase 1 regulatory subunit 7 [Tribolium castaneum] 332373161 BT126760.1 204 1.16423e-99 Dendroctonus ponderosae clone DPO1116_A05 unknown mRNA K17550 PPP1R7, SDS22 protein phosphatase 1 regulatory subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17550 Q5HZV9 606 9.3e-61 Protein phosphatase 1 regulatory subunit 7 OS=Rattus norvegicus GN=Ppp1r7 PE=1 SV=1 PF00560//PF00651//PF01287//PF13912//PF13855//PF00096 Leucine Rich Repeat//BTB/POZ domain//Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//C2H2-type zinc finger//Leucine rich repeat//Zinc finger, C2H2 type GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0005515//GO:0043022//GO:0003723//GO:0046872//GO:0003746 protein binding//ribosome binding//RNA binding//metal ion binding//translation elongation factor activity GO:0005840 ribosome KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.37150 BP_3 11051.00 414.75 1576 91088623 XP_976150.1 1185 4.0e-127 PREDICTED: voltage-dependent anion-selective channel-like [Tribolium castaneum] -- -- -- -- -- K15040 VDAC2 voltage-dependent anion channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15040 Q94920 1012 1.9e-108 Voltage-dependent anion-selective channel OS=Drosophila melanogaster GN=porin PE=1 SV=3 PF01459 Eukaryotic porin GO:0055085 transmembrane transport -- -- GO:0005741 mitochondrial outer membrane KOG3126 Porin/voltage-dependent anion-selective channel protein Cluster-8309.37151 BP_3 172.94 1.98 4501 91081429 XP_973458.1 2077 4.2e-230 PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|642920877|ref|XP_008192597.1| PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|270006127|gb|EFA02575.1| hypothetical protein TcasGA2_TC008293 [Tribolium castaneum] 749790449 XM_011150162.1 133 2.38015e-60 PREDICTED: Harpegnathos saltator ATP-binding cassette sub-family G member 4 (LOC105188614), mRNA K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 Q9H172 1133 5.0e-122 ATP-binding cassette sub-family G member 4 OS=Homo sapiens GN=ABCG4 PE=1 SV=2 PF03193//PF00005//PF13304//PF01926//PF01061 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter GO:0006200 obsolete ATP catabolic process GO:0005525//GO:0005524//GO:0016887//GO:0003924 GTP binding//ATP binding//ATPase activity//GTPase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.37152 BP_3 369.89 14.59 1514 91087671 XP_976426.1 211 3.4e-14 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37153 BP_3 82.71 2.57 1841 478251900 ENN72338.1 2230 3.1e-248 hypothetical protein YQE_10973, partial [Dendroctonus ponderosae]>gi|546680877|gb|ERL91063.1| hypothetical protein D910_08405 [Dendroctonus ponderosae] 170071688 XM_001869946.1 223 8.97247e-111 Culex quinquefasciatus dihydrolipoamide dehydrogenase, mRNA K00382 DLD, lpd, pdhD dihydrolipoamide dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00382 P09623 1847 3.3e-205 Dihydrolipoyl dehydrogenase, mitochondrial OS=Sus scrofa GN=DLD PE=1 SV=1 PF00070//PF01494//PF02852//PF07992 Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0045454 oxidation-reduction process//cell redox homeostasis GO:0071949//GO:0016491 FAD binding//oxidoreductase activity -- -- KOG1335 Dihydrolipoamide dehydrogenase Cluster-8309.37155 BP_3 48817.89 348.42 7045 270008875 EFA05323.1 4398 0.0e+00 hypothetical protein TcasGA2_TC015481 [Tribolium castaneum] 110431373 NM_001042570.1 994 0 Tribolium castaneum chitinase 7 (Cht7), mRNA >gnl|BL_ORD_ID|3159255 Tribolium castaneum chitinase 7 mRNA, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 1007 3.2e-107 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF01607//PF03123 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain//CAT RNA binding domain GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0003723//GO:0004553 chitin binding//RNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region KOG2806 Chitinase Cluster-8309.37156 BP_3 61.46 0.37 8390 189236706 XP_974173.2 1532 1.2e-166 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 349 3.75621e-180 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 652 5.6e-66 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.37157 BP_3 931.28 79.83 854 332375761 AEE63021.1 772 1.7e-79 unknown [Dendroctonus ponderosae] 835986266 XM_004969264.2 48 7.80024e-14 PREDICTED: Setaria italica malate dehydrogenase, mitochondrial-like (LOC101760979), mRNA K00026 MDH2 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00026 Q5NVR2 563 1.2e-56 Malate dehydrogenase, mitochondrial OS=Pongo abelii GN=MDH2 PE=2 SV=1 PF01073//PF02882//PF00056 3-beta hydroxysteroid dehydrogenase/isomerase family//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008209//GO:0006694//GO:0055114//GO:0008207//GO:0009396//GO:0046487//GO:0008210 androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//estrogen metabolic process GO:0016616//GO:0016491//GO:0004488//GO:0003824//GO:0003854 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-8309.37158 BP_3 2198.35 15.02 7345 642930874 XP_008196120.1 1058 9.9e-112 PREDICTED: uncharacterized protein LOC658955 isoform X1 [Tribolium castaneum]>gi|642930876|ref|XP_008196121.1| PREDICTED: uncharacterized protein LOC658955 isoform X1 [Tribolium castaneum] 642930872 XM_965366.2 96 1.44089e-39 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 1.6e-16 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF05495//PF11808 CHY zinc finger//Domain of unknown function (DUF3329) GO:0016310 phosphorylation GO:0008270//GO:0004673 zinc ion binding//protein histidine kinase activity GO:0009365 protein histidine kinase complex -- -- Cluster-8309.37159 BP_3 201.45 2.40 4337 642930308 XP_008196340.1 966 2.7e-101 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 1.3e-34 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF00439//PF03325 Bromodomain//Herpesvirus polymerase accessory protein GO:0019079//GO:0006260 viral genome replication//DNA replication GO:0005515//GO:0030337 protein binding//DNA polymerase processivity factor activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.37160 BP_3 91.85 0.74 6281 91086811 XP_973640.1 2887 0.0e+00 PREDICTED: tetratricopeptide repeat protein 30A [Tribolium castaneum]>gi|270009704|gb|EFA06152.1| hypothetical protein TcasGA2_TC008997 [Tribolium castaneum] 665813619 XM_008557152.1 150 1.17994e-69 PREDICTED: Microplitis demolitor tetratricopeptide repeat protein 30A (LOC103576769), mRNA -- -- -- -- A4IHR1 2287 1.1e-255 Tetratricopeptide repeat protein 30A OS=Xenopus tropicalis GN=ttc30a PE=2 SV=1 PF00112//PF00515//PF13374//PF13414//PF00333//PF13176//PF13181//PF13174//PF00031 Papain family cysteine protease//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Ribosomal protein S5, N-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Cystatin domain GO:0006508//GO:0042254//GO:0006412 proteolysis//ribosome biogenesis//translation GO:0008234//GO:0003735//GO:0003723//GO:0004869//GO:0005515 cysteine-type peptidase activity//structural constituent of ribosome//RNA binding//cysteine-type endopeptidase inhibitor activity//protein binding GO:0005840 ribosome KOG1542 Cysteine proteinase Cathepsin F Cluster-8309.37161 BP_3 185.26 2.08 4589 642930308 XP_008196340.1 966 2.9e-101 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 1.4e-34 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF03325//PF00439 Herpesvirus polymerase accessory protein//Bromodomain GO:0019079//GO:0006260 viral genome replication//DNA replication GO:0005515//GO:0030337 protein binding//DNA polymerase processivity factor activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.37162 BP_3 844.00 18.62 2476 270005577 EFA02025.1 1263 5.7e-136 hypothetical protein TcasGA2_TC007650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U3W5 499 9.1e-49 Putative protein arginine N-methyltransferase 9 OS=Mus musculus GN=Prmt9 PE=2 SV=2 PF05185//PF13414//PF13374//PF13181//PF02390//PF05175 PRMT5 arginine-N-methyltransferase//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Putative methyltransferase//Methyltransferase small domain GO:0006400//GO:0008033//GO:0006479//GO:0009451 tRNA modification//tRNA processing//protein methylation//RNA modification GO:0005515//GO:0008168//GO:0008176 protein binding//methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.37163 BP_3 158.05 2.31 3587 478252681 ENN73077.1 393 6.3e-35 hypothetical protein YQE_10281, partial [Dendroctonus ponderosae]>gi|546682841|gb|ERL92730.1| hypothetical protein D910_10040 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06859 Bicoid-interacting protein 3 (Bin3) -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.37165 BP_3 2234.42 23.32 4910 189238721 XP_970605.2 2529 1.8e-282 PREDICTED: collagen type IV alpha-3-binding protein isoform X1 [Tribolium castaneum]>gi|270010089|gb|EFA06537.1| hypothetical protein TcasGA2_TC009441 [Tribolium castaneum] 194753683 XM_001959104.1 36 2.17105e-06 Drosophila ananassae GF12210 (Dana\GF12210), mRNA K08283 COL4A3BP collagen type IV alpha-3-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08283 Q6VVX2 1509 1.4e-165 Collagen type IV alpha-3-binding protein OS=Cricetulus griseus GN=COL4A3BP PE=1 SV=1 PF08926//PF01852 Domain of unknown function (DUF1908)//START domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0008289//GO:0005543//GO:0000287//GO:0004674 ATP binding//lipid binding//phospholipid binding//magnesium ion binding//protein serine/threonine kinase activity -- -- KOG1737 Oxysterol-binding protein Cluster-8309.37167 BP_3 1002.97 9.74 5253 642928927 XP_008195620.1 2161 8.9e-240 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 263 1.50522e-132 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 512 6.0e-50 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37168 BP_3 807.63 7.83 5266 642928927 XP_008195620.1 2199 3.5e-244 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 282 4.13657e-143 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 559 2.1e-55 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3717 BP_3 2.60 1.29 387 478263644 ENN81950.1 362 2.6e-32 hypothetical protein YQE_01661, partial [Dendroctonus ponderosae]>gi|546676683|gb|ERL87639.1| hypothetical protein D910_05030 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9I7H9 201 5.1e-15 Prolyl 3-hydroxylase sudestada1 OS=Drosophila melanogaster GN=sud1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3844 Predicted component of NuA3 histone acetyltransferase complex Cluster-8309.37170 BP_3 301.09 7.32 2274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00724 NADH:flavin oxidoreductase / NADH oxidase family GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- -- -- Cluster-8309.37171 BP_3 41.16 0.37 5593 546686533 ERL95731.1 499 5.0e-47 hypothetical protein D910_00173, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37172 BP_3 455.12 4.81 4855 546686533 ERL95731.1 499 4.3e-47 hypothetical protein D910_00173, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37173 BP_3 3510.15 50.53 3640 332375456 AEE62869.1 2168 9.6e-241 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 149 2.45028e-69 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 1815 3.4e-201 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF03328//PF00224//PF00478 HpcH/HpaI aldolase/citrate lyase family//Pyruvate kinase, barrel domain//IMP dehydrogenase / GMP reductase domain GO:0006096//GO:0006144//GO:0015976//GO:0006094//GO:0055114 glycolytic process//purine nucleobase metabolic process//carbon utilization//gluconeogenesis//oxidation-reduction process GO:0030955//GO:0003824//GO:0004743//GO:0000287 potassium ion binding//catalytic activity//pyruvate kinase activity//magnesium ion binding -- -- KOG2323 Pyruvate kinase Cluster-8309.37174 BP_3 28650.00 1966.37 994 478251126 ENN71602.1 215 7.6e-15 hypothetical protein YQE_11701, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15798 Proline-rich AKT1 substrate 1 GO:0032007//GO:0048011 negative regulation of TOR signaling//neurotrophin TRK receptor signaling pathway -- -- -- -- -- -- Cluster-8309.37175 BP_3 61476.47 2438.25 1507 91092312 XP_969869.1 565 3.0e-55 PREDICTED: transcriptional regulator DEF1 [Tribolium castaneum]>gi|270015692|gb|EFA12140.1| hypothetical protein TcasGA2_TC002287 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37176 BP_3 196.00 3.06 3384 642922662 XP_008193267.1 705 3.9e-71 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 492 8.0e-48 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005488//GO:0005506//GO:0016491//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding//iron ion binding//oxidoreductase activity//heme binding -- -- -- -- Cluster-8309.37177 BP_3 5308.16 29.89 8850 642934775 XP_008197803.1 5864 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 436 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 3079 0.0e+00 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.37179 BP_3 162.86 1.34 6139 546683632 ERL93420.1 1670 9.0e-183 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 P57094 335 2.3e-29 Axin-1 OS=Danio rerio GN=axin1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37180 BP_3 791.55 7.99 5068 642911420 XP_008199415.1 4264 0.0e+00 PREDICTED: insulin-like receptor [Tribolium castaneum]>gi|642911422|ref|XP_008199416.1| PREDICTED: insulin-like receptor [Tribolium castaneum] 887513390 KP331063.1 128 1.61439e-57 Leptinotarsa decemlineata insulin-like receptor (INR) mRNA, complete cds K04527 INSR insulin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04527 Q93105 2776 1.6e-312 Insulin-like receptor OS=Aedes aegypti GN=InR PE=2 SV=2 PF00041//PF00757//PF07714//PF00069 Fibronectin type III domain//Furin-like cysteine rich region//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0004672//GO:0004714//GO:0005515 ATP binding//protein kinase activity//transmembrane receptor protein tyrosine kinase activity//protein binding GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.37181 BP_3 6761.00 78.33 4452 546679881 ERL90269.1 808 5.9e-83 hypothetical protein D910_07621, partial [Dendroctonus ponderosae] -- -- -- -- -- K11135 PINX1 Pin2-interacting protein X1 http://www.genome.jp/dbget-bin/www_bget?ko:K11135 Q9CZX5 396 1.4e-36 PIN2/TERF1-interacting telomerase inhibitor 1 OS=Mus musculus GN=Pinx1 PE=2 SV=2 PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- KOG2809 Telomerase elongation inhibitor/RNA maturation protein PINX1 Cluster-8309.37182 BP_3 9.00 0.78 850 478252680 ENN73076.1 298 1.5e-24 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37184 BP_3 6.00 0.77 669 808127921 XP_012166870.1 177 1.3e-10 PREDICTED: longitudinals lacking protein, isoforms A/B/D/L-like isoform X18 [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q7KQZ4 150 7.2e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF13912//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BED zinc finger -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.37185 BP_3 9056.34 82.20 5602 255522809 NP_001157317.1 607 1.5e-59 longitudinals lacking isoform 8 [Tribolium castaneum] 255522808 NM_001163845.1 256 1.25026e-128 Tribolium castaneum longitudinals lacking (Lola), transcript variant 8, mRNA -- -- -- -- Q7KQZ4 155 1.6e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF16622//PF13912//PF02892//PF01873//PF00096//PF01403//PF13465 zinc-finger C2H2-type//C2H2-type zinc finger//BED zinc finger//Domain found in IF2B/IF5//Zinc finger, C2H2 type//Sema domain//Zinc-finger double domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003677//GO:0003743//GO:0046872//GO:0005515 DNA binding//translation initiation factor activity//metal ion binding//protein binding GO:0005840 ribosome -- -- Cluster-8309.37187 BP_3 615.70 30.40 1268 22758950 AAN05630.1 556 2.8e-54 diapause-associated transcript-2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37188 BP_3 1304.27 20.40 3373 189239596 XP_967754.2 3165 0.0e+00 PREDICTED: BTB/POZ domain-containing protein KCTD3 [Tribolium castaneum]>gi|270010663|gb|EFA07111.1| hypothetical protein TcasGA2_TC010101 [Tribolium castaneum] 170042981 XM_001849132.1 155 1.04811e-72 Culex quinquefasciatus BTB/POZ domain-containing protein KCTD3, mRNA -- -- -- -- Q8BFX3 1646 1.2e-181 BTB/POZ domain-containing protein KCTD3 OS=Mus musculus GN=Kctd3 PE=2 SV=1 PF02214//PF00651//PF00400 BTB/POZ domain//BTB/POZ domain//WD domain, G-beta repeat GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- KOG2714 SETA binding protein SB1 and related proteins, contain BTB/POZ domain Cluster-8309.37189 BP_3 30.99 3.27 748 -- -- -- -- -- 209571502 NM_001135910.1 85 1.83572e-34 Tribolium castaneum ribosomal protein L41 (Rpl41), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3719 BP_3 1.00 1.18 322 607357226 EZA51692.1 198 2.3e-13 Acetylcholine receptor subunit alpha-like protein [Cerapachys biroi] -- -- -- -- -- -- -- -- -- Q6ZRP5 122 6.1e-06 Putative uncharacterized protein FLJ46204 OS=Homo sapiens PE=5 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37191 BP_3 7848.70 16.15 23711 642935064 XP_008199925.1 9089 0.0e+00 PREDICTED: nesprin-1 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 823 2.3e-85 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF14867//PF10541//PF00837//PF00435 Lantibiotic alpha//Nuclear envelope localisation domain//Iodothyronine deiodinase//Spectrin repeat GO:0055114//GO:0050830 oxidation-reduction process//defense response to Gram-positive bacterium GO:0005515//GO:0004800 protein binding//thyroxine 5'-deiodinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.37192 BP_3 2948.48 26.95 5564 642916747 XP_972619.2 2337 3.7e-260 PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916749|ref|XP_008192467.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916751|ref|XP_008192470.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04422 MAP3K13, LZK mitogen-activated protein kinase kinase kinase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K04422 Q12852 1037 8.4e-111 Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens GN=MAP3K12 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG4721 Serine/threonine protein kinase, contains leucine zipper domain Cluster-8309.37195 BP_3 10.00 0.74 947 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07545 Vestigial/Tondu family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.37197 BP_3 96.92 127.98 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.372 BP_3 2.00 0.83 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37201 BP_3 1197.03 25.42 2561 642935527 XP_973346.2 2214 3.1e-246 PREDICTED: phosphoacetylglucosamine mutase [Tribolium castaneum] 629692694 XM_007813448.1 35 4.0481e-06 Metarhizium acridum CQMa 102 N-acetylglucosamine-phosphate mutase partial mRNA K01836 E5.4.2.3 phosphoacetylglucosamine mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01836 O95394 1460 3.5e-160 Phosphoacetylglucosamine mutase OS=Homo sapiens GN=PGM3 PE=1 SV=1 PF02880//PF05698//PF00408//PF02879//PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Bacterial trigger factor protein (TF) C-terminus//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0005975//GO:0015031//GO:0006457//GO:0071704 carbohydrate metabolic process//protein transport//protein folding//organic substance metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG2537 Phosphoglucomutase/phosphomannomutase Cluster-8309.37202 BP_3 144.00 2.19 3460 270009032 EFA05480.1 175 1.1e-09 hypothetical protein TcasGA2_TC015664 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00614 Phospholipase D Active site motif -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.37203 BP_3 1006.17 4.89 10202 270010025 EFA06473.1 8604 0.0e+00 hypothetical protein TcasGA2_TC009358 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.54934e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01025//PF09141//PF01044//PF02174//PF01608 GrpE//Talin, middle domain//Vinculin family//PTB domain (IRS-1 type)//I/LWEQ domain GO:0007016//GO:0007165//GO:0006457//GO:0007155 cytoskeletal anchoring at plasma membrane//signal transduction//protein folding//cell adhesion GO:0003779//GO:0005158//GO:0042803//GO:0051087//GO:0005200//GO:0051015//GO:0000774 actin binding//insulin receptor binding//protein homodimerization activity//chaperone binding//structural constituent of cytoskeleton//actin filament binding//adenyl-nucleotide exchange factor activity GO:0005899//GO:0001726//GO:0005856//GO:0005925 insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.37205 BP_3 584.87 6.24 4812 642927623 XP_008195338.1 1388 3.5e-150 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] 560970175 XM_006207391.1 80 7.38557e-31 PREDICTED: Vicugna pacos BTB (POZ) domain containing 3 (BTBD3), transcript variant X2, mRNA K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 1014 3.4e-108 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF10501//PF00651 Ribosomal subunit 39S//BTB/POZ domain -- -- GO:0005515 protein binding GO:0005739 mitochondrion KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.37206 BP_3 89576.83 3464.38 1538 575503657 AHG97630.1 1863 9.4e-206 cytochrome oxidase subunit I, partial (mitochondrion) [Batocera horsfieldi] 575503656 KF737820.1 1285 0 Batocera horsfieldi voucher HNAU.PP 041 cytochrome oxidase subunit I gene, partial cds; mitochondrial K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00400 1640 2.8e-181 Cytochrome c oxidase subunit 1 OS=Drosophila yakuba GN=mt:CoI PE=3 SV=2 -- -- -- -- -- -- -- -- KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.37207 BP_3 857.00 113.70 655 91076400 XP_969165.1 299 9.0e-25 PREDICTED: ATP synthase subunit e, mitochondrial [Tribolium castaneum]>gi|270002900|gb|EEZ99347.1| hypothetical protein TcasGA2_TC004872 [Tribolium castaneum] -- -- -- -- -- K02129 ATPeF0E, ATP5I F-type H+-transporting ATPase subunit e http://www.genome.jp/dbget-bin/www_bget?ko:K02129 Q00361 123 9.5e-06 ATP synthase subunit e, mitochondrial OS=Bos taurus GN=ATP5I PE=1 SV=2 PF05680 ATP synthase E chain GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG4326 Mitochondrial F1F0-ATP synthase, subunit e Cluster-8309.37208 BP_3 698.67 5.83 6064 91080927 XP_974039.1 6560 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3107 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF02617//PF01599//PF04183//PF02207 ATP-dependent Clp protease adaptor protein ClpS//Ribosomal protein S27a//IucA / IucC family//Putative zinc finger in N-recognin (UBR box) GO:0019290//GO:0006826//GO:0042254//GO:0030163//GO:0016567//GO:0006412 siderophore biosynthetic process//iron ion transport//ribosome biogenesis//protein catabolic process//protein ubiquitination//translation GO:0008270//GO:0015343//GO:0003735//GO:0004842 zinc ion binding//siderophore transmembrane transporter activity//structural constituent of ribosome//ubiquitin-protein transferase activity GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.3721 BP_3 2.00 1.78 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13014 KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.37211 BP_3 163.00 9.51 1118 91090063 XP_969355.1 875 2.5e-91 PREDICTED: protein SCO1 homolog, mitochondrial [Tribolium castaneum] 874457784 XM_005013934.2 48 1.03115e-13 PREDICTED: Anas platyrhynchos protein SCO1 homolog, mitochondrial (LOC101790131), transcript variant X1, mRNA K07152 SCO1_2 protein SCO1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07152 O75880 630 2.6e-64 Protein SCO1 homolog, mitochondrial OS=Homo sapiens GN=SCO1 PE=1 SV=1 PF00578 AhpC/TSA family GO:0055114 oxidation-reduction process GO:0016209//GO:0016491 antioxidant activity//oxidoreductase activity -- -- KOG2792 Putative cytochrome C oxidase assembly protein Cluster-8309.37213 BP_3 956.71 9.69 5052 642930574 XP_008198195.1 1554 2.1e-169 PREDICTED: excitatory amino acid transporter 3-like [Tribolium castaneum]>gi|270009376|gb|EFA05824.1| hypothetical protein TcasGA2_TC008606 [Tribolium castaneum] 527266023 XM_005151139.1 53 7.92309e-16 PREDICTED: Melopsittacus undulatus solute carrier family 1 (glutamate transporter), member 7 (LOC101873134), mRNA K05612 SLC1A1, EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05612 P31597 940 1.4e-99 Excitatory amino acid transporter 3 OS=Oryctolagus cuniculus GN=SLC1A1 PE=2 SV=1 PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.37214 BP_3 306.62 12.27 1496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37216 BP_3 44.61 0.63 3723 270014971 EFA11419.1 1641 1.3e-179 hypothetical protein TcasGA2_TC013596 [Tribolium castaneum] 290048170 GU396008.1 405 0 Helicoverpa armigera arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 P48610 1581 4.7e-174 Arginine kinase OS=Drosophila melanogaster GN=Argk PE=2 SV=2 PF02807//PF00217 ATP:guanido phosphotransferase, N-terminal domain//ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.37217 BP_3 1175.95 53.51 1351 642914157 XP_008201570.1 601 1.8e-59 PREDICTED: muscle-specific protein 20 isoform X1 [Tribolium castaneum] 780694807 XM_011702209.1 83 4.37543e-33 PREDICTED: Wasmannia auropunctata muscle-specific protein 20-like (LOC105457507), transcript variant X2, mRNA -- -- -- -- P14318 464 5.7e-45 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.37219 BP_3 49.93 0.32 7765 642928117 XP_008200164.1 422 5.9e-38 PREDICTED: protein anoxia up-regulated isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37220 BP_3 96.55 0.44 10816 642935263 XP_008197938.1 6611 0.0e+00 PREDICTED: hemocytin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98092 5375 0.0e+00 Hemocytin OS=Bombyx mori PE=2 SV=1 PF00093//PF05375//PF11051//PF05805 von Willebrand factor type C domain//Pacifastin inhibitor (LCMII)//Mannosyltransferase putative//L6 membrane protein GO:0006486 protein glycosylation GO:0030414//GO:0005515//GO:0016757 peptidase inhibitor activity//protein binding//transferase activity, transferring glycosyl groups GO:0016021 integral component of membrane -- -- Cluster-8309.37221 BP_3 47.39 0.71 3498 91090103 XP_970810.1 1785 2.4e-196 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 160947857 EU258622.1 288 1.26498e-146 Spodoptera exigua ribosomal protein L10 (RpL10) mRNA, complete cds K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O96647 1088 6.5e-117 60S ribosomal protein L10 OS=Bombyx mandarina GN=RpL10 PE=2 SV=1 PF14634//PF00252//PF13639 zinc-RING finger domain//Ribosomal protein L16p/L10e//Ring finger domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735//GO:0005515//GO:0046872 zinc ion binding//structural constituent of ribosome//protein binding//metal ion binding GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.37223 BP_3 44.45 0.72 3253 642936134 XP_008198313.1 2274 4.4e-253 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 475 0 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q55EH8 634 2.6e-64 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF00005//PF03193//PF01061//PF01637//PF13304 ABC transporter//Protein of unknown function, DUF258//ABC-2 type transporter//Archaeal ATPase//AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005525//GO:0005524//GO:0016887//GO:0003924 GTP binding//ATP binding//ATPase activity//GTPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.37224 BP_3 28.40 0.68 2315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37225 BP_3 114352.08 402.36 13990 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00770//PF05493 Adenovirus endoprotease//ATP synthase subunit H GO:0015992//GO:0015991//GO:0006508 proton transport//ATP hydrolysis coupled proton transport//proteolysis GO:0004197//GO:0015078 cysteine-type endopeptidase activity//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.37226 BP_3 11.00 15.71 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37227 BP_3 2385.00 37.31 3373 270011110 EFA07558.1 1126 5.9e-120 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 762 3.9e-79 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF02949//PF08367 Trypsin//7tm Odorant receptor//Peptidase M16C associated GO:0006508//GO:0007608//GO:0007187 proteolysis//sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0005549//GO:0004252//GO:0004984 odorant binding//serine-type endopeptidase activity//olfactory receptor activity GO:0016020 membrane -- -- Cluster-8309.37229 BP_3 33.75 0.83 2242 642916567 XP_972160.2 740 2.3e-75 PREDICTED: solute carrier family 35 member C2 [Tribolium castaneum] -- -- -- -- -- K15280 SLC35C2 solute carrier family 35, member C2 http://www.genome.jp/dbget-bin/www_bget?ko:K15280 Q8VCX2 361 8.3e-33 Solute carrier family 35 member C2 OS=Mus musculus GN=Slc35c2 PE=1 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1443 Predicted integral membrane protein Cluster-8309.37232 BP_3 60.09 1.92 1804 91083175 XP_972331.1 431 1.2e-39 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 323 1.7e-28 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.37233 BP_3 108.61 1.45 3908 642928913 XP_971104.2 1611 4.0e-176 PREDICTED: FK506-binding protein 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05891 AdoMet dependent proline di-methyltransferase GO:0006480 N-terminal protein amino acid methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.37235 BP_3 233.85 4.10 3043 478250396 ENN70891.1 1074 5.7e-114 hypothetical protein YQE_12296, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8AWW5 248 1.4e-19 Cysteine-rich motor neuron 1 protein OS=Gallus gallus GN=CRIM1 PE=2 SV=1 PF00093//PF02822 von Willebrand factor type C domain//Antistasin family -- -- GO:0005515//GO:0004867 protein binding//serine-type endopeptidase inhibitor activity -- -- KOG1216 von Willebrand factor and related coagulation proteins Cluster-8309.37236 BP_3 24.25 0.61 2223 91081249 XP_975650.1 377 2.8e-33 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q80UU9 280 2.0e-23 Membrane-associated progesterone receptor component 2 OS=Mus musculus GN=Pgrmc2 PE=1 SV=2 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.37237 BP_3 496.57 10.03 2679 91084651 XP_967087.1 1472 3.6e-160 PREDICTED: leucine-rich repeat-containing protein 47 [Tribolium castaneum]>gi|270008920|gb|EFA05368.1| hypothetical protein TcasGA2_TC015534 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q505F5 744 3.8e-77 Leucine-rich repeat-containing protein 47 OS=Mus musculus GN=Lrrc47 PE=2 SV=1 PF03483//PF13855//PF00560 B3/4 domain//Leucine rich repeat//Leucine Rich Repeat GO:0006432//GO:0009094//GO:0006571//GO:0000162 phenylalanyl-tRNA aminoacylation//L-phenylalanine biosynthetic process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0003723//GO:0004826//GO:0005515 RNA binding//phenylalanine-tRNA ligase activity//protein binding GO:0009328 phenylalanine-tRNA ligase complex KOG0619 FOG: Leucine rich repeat Cluster-8309.37238 BP_3 680.33 6.87 5065 91087995 XP_973673.1 3733 0.0e+00 PREDICTED: protein transport protein Sec31A [Tribolium castaneum] -- -- -- -- -- K14005 SEC31 protein transport protein SEC31 http://www.genome.jp/dbget-bin/www_bget?ko:K14005 Q7SYD5 1892 5.5e-210 Protein transport protein Sec31A OS=Danio rerio GN=sec31a PE=2 SV=1 PF00830//PF00400//PF07808 Ribosomal L28 family//WD domain, G-beta repeat//RED-like protein N-terminal region GO:0042254 ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005634//GO:0005840 nucleus//ribosome KOG0307 Vesicle coat complex COPII, subunit SEC31 Cluster-8309.37240 BP_3 6428.82 1273.17 535 642926225 XP_008194836.1 502 2.1e-48 PREDICTED: 60S ribosomal protein L22 [Tribolium castaneum]>gi|270009023|gb|EFA05471.1| hypothetical protein TcasGA2_TC015654 [Tribolium castaneum] 762137041 XM_011453508.1 50 3.68416e-15 PREDICTED: Crassostrea gigas 60S ribosomal protein L22-like (LOC105345379), mRNA K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 309 2.1e-27 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 PF01776 Ribosomal L22e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3434 60S ribosomal protein L22 Cluster-8309.37241 BP_3 72.81 2.31 1808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37242 BP_3 10.92 0.37 1721 91093431 XP_969079.1 530 3.9e-51 PREDICTED: AMMECR1-like protein [Tribolium castaneum]>gi|270015455|gb|EFA11903.1| hypothetical protein TcasGA2_TC004060 [Tribolium castaneum] 880861289 XM_005065312.2 58 4.42635e-19 PREDICTED: Mesocricetus auratus AMMECR1-like (Ammecr1l), transcript variant X3, mRNA -- -- -- -- Q5RAS7 441 3.4e-42 AMME syndrome candidate gene 1 protein homolog OS=Pongo abelii GN=AMMECR1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3274 Uncharacterized conserved protein, AMMECR1 Cluster-8309.37243 BP_3 172.09 0.71 12038 642911579 XP_008200659.1 3070 0.0e+00 PREDICTED: patched isoform X1 [Tribolium castaneum] 197276677 NM_001134377.1 274 2.65702e-138 Tribolium castaneum patched (Ptc), mRNA K15013 ACSBG long-chain-fatty-acid--CoA ligase ACSBG http://www.genome.jp/dbget-bin/www_bget?ko:K15013 Q9V3S9 1612 3.9e-177 Very long-chain-fatty-acid--CoA ligase bubblegum OS=Drosophila melanogaster GN=bgm PE=2 SV=1 PF02460//PF16499//PF02116//PF00501//PF08941 Patched family//Alpha galactosidase A//Fungal pheromone mating factor STE2 GPCR//AMP-binding enzyme//USP8 interacting GO:0007186//GO:0019236//GO:0007606//GO:0005975//GO:0007165//GO:0008152//GO:0016567 G-protein coupled receptor signaling pathway//response to pheromone//sensory perception of chemical stimulus//carbohydrate metabolic process//signal transduction//metabolic process//protein ubiquitination GO:0016881//GO:0004932//GO:0003824//GO:0031386//GO:0008158//GO:0004553 acid-amino acid ligase activity//mating-type factor pheromone receptor activity//catalytic activity//protein tag//hedgehog receptor activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016020 membrane -- -- Cluster-8309.37244 BP_3 41.24 1.05 2189 478251126 ENN71602.1 460 6.5e-43 hypothetical protein YQE_11701, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.37245 BP_3 231.04 2.12 5541 134053892 NP_001076809.1 1502 2.5e-163 adipokinetic hormone receptor [Tribolium castaneum]>gi|642928766|ref|XP_008195552.1| PREDICTED: adipokinetic hormone receptor isoform X1 [Tribolium castaneum]>gi|90903321|gb|ABE02225.1| adipokinetic hormone receptor [Tribolium castaneum]>gi|126116536|gb|ABN79650.1| adipokinetic hormone receptor [Tribolium castaneum]>gi|270011068|gb|EFA07516.1| hypothetical protein TcasGA2_TC009772, partial [Tribolium castaneum] -- -- -- -- -- K04280 GNRHR gonadotropin-releasing hormone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04280 O42329 567 2.6e-56 Gonadotropin-releasing hormone II receptor OS=Clarias gariepinus PE=2 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0097211//GO:0007187//GO:0007186 cellular response to gonadotropin-releasing hormone//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//G-protein coupled receptor signaling pathway GO:0004968//GO:0004930 gonadotropin-releasing hormone receptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.37247 BP_3 59.62 2.78 1325 91085253 XP_973335.1 929 1.6e-97 PREDICTED: uncharacterized protein LOC662125 [Tribolium castaneum]>gi|270009097|gb|EFA05545.1| hypothetical protein TcasGA2_TC015733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00584 SecE/Sec61-gamma subunits of protein translocation complex GO:0006886//GO:0006605 intracellular protein transport//protein targeting -- -- GO:0016020 membrane -- -- Cluster-8309.37250 BP_3 62.23 0.50 6299 642919356 XP_008191837.1 2309 7.4e-257 PREDICTED: kinesin-like protein costa isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16844 969 7.3e-103 Kinesin-like protein costa OS=Drosophila melanogaster GN=cos PE=1 SV=2 PF16367//PF00225 RNA recognition motif//Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0003777//GO:0008017//GO:0003676 ATP binding//microtubule motor activity//microtubule binding//nucleic acid binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG4280 Kinesin-like protein Cluster-8309.37254 BP_3 5702.78 70.11 4212 166851824 NP_001107778.1 772 8.3e-79 cuticular protein analogous to peritrophins 3-C5 isoform 2 precursor [Tribolium castaneum]>gi|119387890|gb|ABL73930.1| obstractor C2 [Tribolium castaneum] 817185116 XM_012429676.1 188 5.93213e-91 PREDICTED: Orussus abietinus uncharacterized LOC105702248 (LOC105702248), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.37255 BP_3 26137.71 437.24 3173 121583754 NP_001073569.1 1223 3.2e-131 cuticular protein analogous to peritrophins 3-C5 isoform 1 precursor [Tribolium castaneum]>gi|119387888|gb|ABL73929.1| obstractor C1 [Tribolium castaneum] 121583753 NM_001080100.1 324 1.11425e-166 Tribolium castaneum cuticular protein analogous to peritrophins 3-C5 (Cpap3-c5), transcript variant 1, mRNA >gnl|BL_ORD_ID|3647361 Tribolium castaneum obstractor C1 (Obst-C1) mRNA, complete cds -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.37256 BP_3 1659.23 37.67 2415 332372937 AEE61610.1 1260 1.2e-135 unknown [Dendroctonus ponderosae]>gi|546684868|gb|ERL94450.1| hypothetical protein D910_11727 [Dendroctonus ponderosae] 758277713 KP113812.1 111 2.15391e-48 Acraea encedon voucher fj55_3 cytosolic malate dehydrogenase (Cmdh) gene, partial cds K00025 MDH1 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00025 Q5ZME2 1033 1.1e-110 Malate dehydrogenase, cytoplasmic OS=Gallus gallus GN=MDH1 PE=2 SV=1 PF02866//PF00056 lactate/malate dehydrogenase, alpha/beta C-terminal domain//lactate/malate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016616//GO:0016491 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1496 Malate dehydrogenase Cluster-8309.37257 BP_3 129.00 0.45 14187 189233641 XP_001814986.1 2409 4.2e-268 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 242018850 XM_002429839.1 113 9.89329e-49 Pediculus humanus corporis nicotinate phosphoribosyltransferase, putative, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2054 2.5e-228 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF01213//PF02892//PF13912//PF08603//PF02749//PF13465//PF07776//PF00096 Adenylate cyclase associated (CAP) N terminal//BED zinc finger//C2H2-type zinc finger//Adenylate cyclase associated (CAP) C terminal//Quinolinate phosphoribosyl transferase, N-terminal domain//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type GO:0007010 cytoskeleton organization GO:0046872//GO:0003779//GO:0016763//GO:0003677//GO:0008270 metal ion binding//actin binding//transferase activity, transferring pentosyl groups//DNA binding//zinc ion binding GO:0005634 nucleus KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.37259 BP_3 22.57 0.78 1691 642914581 XP_008190273.1 1541 2.2e-168 PREDICTED: uncharacterized protein LOC660922 isoform X1 [Tribolium castaneum] 642914580 XM_008192051.1 299 4.64609e-153 PREDICTED: Tribolium castaneum uncharacterized LOC660922 (LOC660922), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37260 BP_3 1462.82 42.21 1962 478251900 ENN72338.1 2250 1.6e-250 hypothetical protein YQE_10973, partial [Dendroctonus ponderosae]>gi|546680877|gb|ERL91063.1| hypothetical protein D910_08405 [Dendroctonus ponderosae] 170071688 XM_001869946.1 223 9.57361e-111 Culex quinquefasciatus dihydrolipoamide dehydrogenase, mRNA K00382 DLD, lpd, pdhD dihydrolipoamide dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00382 P09623 1847 3.5e-205 Dihydrolipoyl dehydrogenase, mitochondrial OS=Sus scrofa GN=DLD PE=1 SV=1 PF01494//PF07992//PF02852//PF12831//PF05834//PF01266//PF01134//PF00070//PF03721 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//FAD dependent oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GO:0016117//GO:0045454//GO:0055114//GO:0008033 carotenoid biosynthetic process//cell redox homeostasis//oxidation-reduction process//tRNA processing GO:0016705//GO:0071949//GO:0016616//GO:0051287//GO:0016491//GO:0050660 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity//flavin adenine dinucleotide binding -- -- KOG1335 Dihydrolipoamide dehydrogenase Cluster-8309.37261 BP_3 235.91 4.36 2902 642925507 XP_008194579.1 1939 2.7e-214 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.49961e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 P47820 1281 2.2e-139 Angiotensin-converting enzyme OS=Rattus norvegicus GN=Ace PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.37262 BP_3 88.52 0.92 4950 91094029 XP_967706.1 1178 8.1e-126 PREDICTED: mitochondrial inner membrane protein COX18 [Tribolium castaneum] -- -- -- -- -- K17797 COX18 mitochondrial inner membrane protein COX18 http://www.genome.jp/dbget-bin/www_bget?ko:K17797 Q8VC74 650 5.6e-66 Mitochondrial inner membrane protein COX18 OS=Mus musculus GN=Cox18 PE=2 SV=5 PF02096//PF00651 60Kd inner membrane protein//BTB/POZ domain GO:0051205 protein insertion into membrane GO:0005515 protein binding GO:0016021 integral component of membrane KOG1239 Inner membrane protein translocase involved in respiratory chain assembly Cluster-8309.37265 BP_3 381.25 3.56 5456 642927078 XP_008195127.1 1453 1.2e-157 PREDICTED: probable G-protein coupled receptor Mth-like 5 [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VGG8 1038 6.3e-111 Probable G-protein coupled receptor Mth-like 5 OS=Drosophila melanogaster GN=mthl5 PE=2 SV=2 PF02742//PF00002//PF00001 Iron dependent repressor, metal binding and dimerisation domain//7 transmembrane receptor (Secretin family)//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0046914//GO:0004930//GO:0046983 transition metal ion binding//G-protein coupled receptor activity//protein dimerization activity GO:0016021 integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.37267 BP_3 977.46 24.05 2251 91089533 XP_971109.1 674 1.0e-67 PREDICTED: synaptogyrin-1 [Tribolium castaneum]>gi|270011384|gb|EFA07832.1| hypothetical protein TcasGA2_TC005401 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43760 261 3.3e-21 Synaptogyrin-2 OS=Homo sapiens GN=SYNGR2 PE=1 SV=1 PF01529//PF01484//PF01284 DHHC palmitoyltransferase//Nematode cuticle collagen N-terminal domain//Membrane-associating domain -- -- GO:0008270//GO:0042302 zinc ion binding//structural constituent of cuticle GO:0016020 membrane -- -- Cluster-8309.37268 BP_3 1613.93 103.55 1043 91094039 XP_968178.1 740 1.1e-75 PREDICTED: cofilin/actin-depolymerizing factor homolog [Tribolium castaneum]>gi|270003140|gb|EEZ99587.1| hypothetical protein TcasGA2_TC001574 [Tribolium castaneum] 642915784 XM_963085.2 240 1.77817e-120 PREDICTED: Tribolium castaneum cofilin/actin-depolymerizing factor homolog (LOC656560), mRNA K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 673 2.5e-69 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1735 Actin depolymerizing factor Cluster-8309.37269 BP_3 27.19 0.54 2697 478257427 ENN77583.1 2231 3.5e-248 hypothetical protein YQE_05879, partial [Dendroctonus ponderosae]>gi|546685706|gb|ERL95167.1| hypothetical protein D910_12436 [Dendroctonus ponderosae] -- -- -- -- -- K00294 E1.2.1.88 1-pyrroline-5-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00294 P0C2X9 1560 9.2e-172 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Aldh4a1 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2455 Delta-1-pyrroline-5-carboxylate dehydrogenase Cluster-8309.37270 BP_3 75.00 2.11 2008 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37272 BP_3 420.33 14.50 1689 642915492 XP_008190639.1 1194 3.9e-128 PREDICTED: glycerol kinase [Tribolium castaneum]>gi|642915494|ref|XP_008190640.1| PREDICTED: glycerol kinase [Tribolium castaneum]>gi|270003860|gb|EFA00308.1| hypothetical protein TcasGA2_TC003143 [Tribolium castaneum] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q63060 786 3.3e-82 Glycerol kinase OS=Rattus norvegicus GN=Gk PE=2 SV=1 PF00370 FGGY family of carbohydrate kinases, N-terminal domain GO:0006072//GO:0046486//GO:0016310//GO:0005975 glycerol-3-phosphate metabolic process//glycerolipid metabolic process//phosphorylation//carbohydrate metabolic process GO:0004370//GO:0016773 glycerol kinase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.37273 BP_3 2610.53 409.43 599 91079048 XP_975100.1 564 1.5e-55 PREDICTED: myophilin [Tribolium castaneum]>gi|270003661|gb|EFA00109.1| hypothetical protein TcasGA2_TC002925 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14318 281 4.2e-24 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.37275 BP_3 138.28 1.68 4259 642921997 XP_008192975.1 1073 1.0e-113 PREDICTED: calcium uniporter protein, mitochondrial [Tribolium castaneum] 884952751 XM_013134023.1 63 1.84157e-21 PREDICTED: Esox lucius mitochondrial calcium uniporter (mcu), transcript variant X2, mRNA -- -- -- -- Q08BI9 672 1.4e-68 Calcium uniporter protein, mitochondrial OS=Danio rerio GN=mcu PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2966 Uncharacterized conserved protein Cluster-8309.37277 BP_3 954.88 22.42 2345 189241306 XP_975247.2 1469 7.0e-160 PREDICTED: protein croquemort-like [Tribolium castaneum]>gi|642936188|ref|XP_008198333.1| PREDICTED: protein croquemort-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 645 1.0e-65 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF06209//PF01130 Cofactor of BRCA1 (COBRA1)//CD36 family GO:0045892//GO:0007155 negative regulation of transcription, DNA-templated//cell adhesion -- -- GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.37279 BP_3 883.56 10.39 4391 91093203 XP_969368.1 999 4.1e-105 PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|642938151|ref|XP_008199786.1| PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|270016483|gb|EFA12929.1| hypothetical protein TcasGA2_TC010475 [Tribolium castaneum] 170043832 XM_001849523.1 373 0 Culex quinquefasciatus hippocalcin, mRNA -- -- -- -- P42325 984 9.3e-105 Neurocalcin homolog OS=Drosophila melanogaster GN=Nca PE=1 SV=2 PF13202//PF00036//PF11095//PF12763//PF13499//PF02745//PF10591//PF13833//PF13405 EF hand//EF hand//Gem-associated protein 7 (Gemin7)//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Methyl-coenzyme M reductase alpha subunit, N-terminal domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0007165//GO:0015948//GO:0046656 signal transduction//methanogenesis//folic acid biosynthetic process GO:0005509//GO:0050524//GO:0005515 calcium ion binding//coenzyme-B sulfoethylthiotransferase activity//protein binding GO:0005578//GO:0032797 proteinaceous extracellular matrix//SMN complex KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.3728 BP_3 2.00 0.69 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08187 Myoactive tetradecapeptides family GO:0007218 neuropeptide signaling pathway GO:0005184 neuropeptide hormone activity GO:0005576 extracellular region -- -- Cluster-8309.37280 BP_3 2988.08 15.93 9332 270010611 EFA07059.1 1520 3.4e-165 hypothetical protein TcasGA2_TC010036 [Tribolium castaneum] 189239538 XM_970519.2 321 1.53557e-164 PREDICTED: Tribolium castaneum ras-related protein Rab-23 (LOC664521), mRNA K06234 RAB23 Ras-related protein Rab-23 http://www.genome.jp/dbget-bin/www_bget?ko:K06234 Q9ULC3 565 7.6e-56 Ras-related protein Rab-23 OS=Homo sapiens GN=RAB23 PE=1 SV=1 PF08477//PF00735//PF01926//PF12106//PF00025//PF02421//PF03193//PF04670//PF00071//PF10662 Ras of Complex, Roc, domain of DAPkinase//Septin//50S ribosome-binding GTPase//Colicin C terminal ribonuclease domain//ADP-ribosylation factor family//Ferrous iron transport protein B//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation GO:0006576//GO:0007264//GO:0015684//GO:0051252 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport//regulation of RNA metabolic process GO:0005524//GO:0015093//GO:0004540//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//ribonuclease activity//GTPase activity//GTP binding GO:0016021 integral component of membrane KOG0079 GTP-binding protein H-ray, small G protein superfamily Cluster-8309.37281 BP_3 59.22 1.13 2807 91080533 XP_972324.1 2941 0.0e+00 PREDICTED: alpha-actinin, sarcomeric isoform X2 [Tribolium castaneum] 795041623 XM_012011607.1 512 0 PREDICTED: Vollenhovia emeryi alpha-actinin, sarcomeric (LOC105561541), transcript variant X4, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 P18091 2761 5.2e-311 Alpha-actinin, sarcomeric OS=Drosophila melanogaster GN=Actn PE=1 SV=2 PF13499//PF13833//PF00036//PF13405//PF00435//PF00307//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Spectrin repeat//Calponin homology (CH) domain//EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.37283 BP_3 588.54 6.19 4875 546675851 ERL86956.1 2118 8.0e-235 hypothetical protein D910_04359 [Dendroctonus ponderosae] 676491074 XM_009067230.1 96 9.54387e-40 Lottia gigantea hypothetical protein mRNA K12179 COPS6, CSN6 COP9 signalosome complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12179 Q9VCY3 1146 1.7e-123 COP9 signalosome complex subunit 6 OS=Drosophila melanogaster GN=CSN6 PE=1 SV=1 PF00848//PF01398//PF05028 Ring hydroxylating alpha subunit (catalytic domain)//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Poly (ADP-ribose) glycohydrolase (PARG) GO:0019439//GO:0055114//GO:0005975 aromatic compound catabolic process//oxidation-reduction process//carbohydrate metabolic process GO:0005515//GO:0051537//GO:0004649//GO:0005506//GO:0016708 protein binding//2 iron, 2 sulfur cluster binding//poly(ADP-ribose) glycohydrolase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor -- -- KOG3050 COP9 signalosome, subunit CSN6 Cluster-8309.37285 BP_3 614.86 5.05 6159 642923353 XP_008193715.1 2686 1.4e-300 PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q80VJ4 958 1.3e-101 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Rattus norvegicus GN=Gpcpd1 PE=2 SV=1 PF00686//PF03009 Starch binding domain//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:0008081//GO:2001070 phosphoric diester hydrolase activity//starch binding -- -- KOG2421 Predicted starch-binding protein Cluster-8309.37288 BP_3 473.66 2.08 11262 642933099 XP_973043.3 3459 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.3e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF14572//PF00076//PF08587 Phosphoribosyl transferase domain//Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ubiquitin associated domain (UBA) GO:0009116//GO:0006098//GO:0016310//GO:0009165//GO:0006144//GO:0009069 nucleoside metabolic process//pentose-phosphate shunt//phosphorylation//nucleotide biosynthetic process//purine nucleobase metabolic process//serine family amino acid metabolic process GO:0003676//GO:0004674//GO:0000287//GO:0004749 nucleic acid binding//protein serine/threonine kinase activity//magnesium ion binding//ribose phosphate diphosphokinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.37289 BP_3 1681.19 6.77 12253 91092426 XP_968165.1 6155 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC1 [Tribolium castaneum]>gi|270004743|gb|EFA01191.1| hypothetical protein TcasGA2_TC010518 [Tribolium castaneum] 617460781 XM_007571860.1 414 0 PREDICTED: Poecilia formosa ATP-binding cassette, sub-family E (OABP), member 1 (abce1), mRNA K03018 RPC1, POLR3A DNA-directed RNA polymerase III subunit RPC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03018 Q5ZL98 4386 0.0e+00 DNA-directed RNA polymerase III subunit RPC1 OS=Gallus gallus GN=POLR3A PE=2 SV=1 PF00004//PF05000//PF04983//PF08477//PF07728//PF13304//PF00931//PF04998//PF00623//PF02367//PF04997//PF06810//PF01920//PF00448//PF07352//PF07851//PF00910//PF03193//PF00005 ATPase family associated with various cellular activities (AAA)//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 3//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//AAA domain, putative AbiEii toxin, Type IV TA system//NB-ARC domain//RNA polymerase Rpb1, domain 5//RNA polymerase Rpb1, domain 2//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA polymerase Rpb1, domain 1//Phage minor structural protein GP20//Prefoldin subunit//SRP54-type protein, GTPase domain//Bacteriophage Mu Gam like protein//TMPIT-like protein//RNA helicase//Protein of unknown function, DUF258//ABC transporter GO:0006614//GO:0006457//GO:0042262//GO:0006351//GO:0006144//GO:0006206//GO:0002949//GO:0007264 SRP-dependent cotranslational protein targeting to membrane//protein folding//DNA protection//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0003899//GO:0005524//GO:0003924//GO:0005198//GO:0016887//GO:0051082//GO:0008270//GO:0003677//GO:0003723//GO:0043531//GO:0032549//GO:0005525//GO:0003724//GO:0003690 DNA-directed RNA polymerase activity//ATP binding//GTPase activity//structural molecule activity//ATPase activity//unfolded protein binding//zinc ion binding//DNA binding//RNA binding//ADP binding//ribonucleoside binding//GTP binding//RNA helicase activity//double-stranded DNA binding GO:0016021//GO:0005730//GO:0016272//GO:0005634 integral component of membrane//nucleolus//prefoldin complex//nucleus KOG0261 RNA polymerase III, large subunit Cluster-8309.37290 BP_3 54.38 1.54 1989 642923254 XP_008193679.1 749 1.8e-76 PREDICTED: DNA repair protein XRCC3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q08DH8 411 1.2e-38 DNA repair protein XRCC3 OS=Bos taurus GN=XRCC3 PE=2 SV=1 PF03796//PF00154 DnaB-like helicase C terminal domain//recA bacterial DNA recombination protein GO:0009432//GO:0006260//GO:0006281 SOS response//DNA replication//DNA repair GO:0005524//GO:0003678//GO:0003697 ATP binding//DNA helicase activity//single-stranded DNA binding GO:0005657 replication fork KOG1564 DNA repair protein RHP57 Cluster-8309.37291 BP_3 24.94 0.79 1805 478250804 ENN71296.1 582 3.8e-57 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10976 ERO1LB ERO1-like protein beta http://www.genome.jp/dbget-bin/www_bget?ko:K10976 Q9V3A6 419 1.3e-39 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137//PF02251 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//Proteasome activator pa28 alpha subunit GO:0055114 oxidation-reduction process GO:0003756//GO:0016671 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0005783//GO:0008537 endoplasmic reticulum//proteasome activator complex KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.37293 BP_3 33.57 0.50 3503 270011456 EFA07904.1 2261 1.5e-251 hypothetical protein TcasGA2_TC005479 [Tribolium castaneum] 642933027 XM_965305.2 396 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 1858 3.3e-206 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.37295 BP_3 618.16 29.41 1305 189238710 XP_969341.2 1871 9.4e-207 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 662207554 XM_008479062.1 42 2.61423e-10 PREDICTED: Diaphorina citri trichohyalin-like (LOC103514197), mRNA -- -- -- -- Q9JM99 220 1.1e-16 Proteoglycan 4 OS=Mus musculus GN=Prg4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37296 BP_3 743.96 7.67 4966 189234232 XP_973217.2 2793 0.0e+00 PREDICTED: serine/threonine-protein kinase Warts [Tribolium castaneum]>gi|270002603|gb|EEZ99050.1| hypothetical protein TcasGA2_TC004924 [Tribolium castaneum] 815821612 XM_012376640.1 417 0 PREDICTED: Linepithema humile serine/threonine-protein kinase Warts (LOC105677787), mRNA K08791 LATS1_2, Wts serine/threonine-protein kinase LATS1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08791 Q9VA38 1722 2.8e-190 Serine/threonine-protein kinase Warts OS=Drosophila melanogaster GN=wts PE=1 SV=1 PF03152//PF00069//PF06293//PF07714 Ubiquitin fusion degradation protein UFD1//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006511//GO:0006468//GO:0016310 ubiquitin-dependent protein catabolic process//protein phosphorylation//phosphorylation GO:0000166//GO:0016773//GO:0004672//GO:0005524 nucleotide binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding GO:0016020 membrane KOG0605 NDR and related serine/threonine kinases Cluster-8309.37297 BP_3 310.43 1.12 13616 546673612 ERL85176.1 9589 0.0e+00 hypothetical protein D910_02598 [Dendroctonus ponderosae] 642911102 XM_008202356.1 2856 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X6, mRNA -- -- -- -- Q23551 4808 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF02480//PF01344//PF16794//PF01891//PF15170//PF16656//PF01300//PF00041//PF13895//PF01108 Alphaherpesvirus glycoprotein E//Kelch motif//Fibronectin-III type domain//Cobalt uptake substrate-specific transmembrane region//Calcium/calmodulin-dependent protein kinase II inhibitor//Purple acid Phosphatase, N-terminal domain//Telomere recombination//Fibronectin type III domain//Immunoglobulin domain//Tissue factor GO:0006771//GO:0000041//GO:0019497//GO:0045859 riboflavin metabolic process//transition metal ion transport//hexachlorocyclohexane metabolic process//regulation of protein kinase activity GO:0046872//GO:0003725//GO:0003993//GO:0005515//GO:0004860 metal ion binding//double-stranded RNA binding//acid phosphatase activity//protein binding//protein kinase inhibitor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.37298 BP_3 122.49 3.64 1913 332375618 AEE62950.1 1358 4.2e-147 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02175 BRN putative enzyme (brainiac) http://www.genome.jp/dbget-bin/www_bget?ko:K02175 Q24157 635 1.2e-64 Beta-1,3-galactosyltransferase brn OS=Drosophila melanogaster GN=brn PE=2 SV=2 PF05557//PF02434//PF01762 Mitotic checkpoint protein//Fringe-like//Galactosyltransferase GO:0006486//GO:0007094 protein glycosylation//mitotic spindle assembly checkpoint GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.37299 BP_3 36.65 0.34 5540 270005127 EFA01575.1 1872 3.1e-206 hypothetical protein TcasGA2_TC007136 [Tribolium castaneum] 674656866 KJ872589.1 597 0 Monochamus alternatus muscle LIM protein mRNA, partial cds -- -- -- -- Q24400 1544 1.4e-169 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412//PF00643//PF00096//PF03119 LIM domain//B-box zinc finger//Zinc finger, C2H2 type//NAD-dependent DNA ligase C4 zinc finger domain GO:0006281//GO:0006260 DNA repair//DNA replication GO:0046872//GO:0008270//GO:0003911 metal ion binding//zinc ion binding//DNA ligase (NAD+) activity GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.373 BP_3 57.00 1.25 2497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37300 BP_3 444.37 12.99 1941 91089929 XP_973045.1 203 3.6e-13 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37301 BP_3 311.56 1.83 8510 270012359 EFA08807.1 1919 1.7e-211 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.3e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF08783//PF02817//PF04564//PF00098//PF14634//PF01588//PF00097//PF13639//PF00198 DWNN domain//e3 binding domain//U-box domain//Zinc knuckle//zinc-RING finger domain//Putative tRNA binding domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain) GO:0016567//GO:0008152 protein ubiquitination//metabolic process GO:0004842//GO:0016746//GO:0005515//GO:0000049//GO:0046872//GO:0008270//GO:0003676 ubiquitin-protein transferase activity//transferase activity, transferring acyl groups//protein binding//tRNA binding//metal ion binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.37306 BP_3 41.91 0.87 2613 91077504 XP_966852.1 2162 3.4e-240 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P26779 405 7.6e-38 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF02627//PF05184 Carboxymuconolactone decarboxylase family//Saposin-like type B, region 1 GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process GO:0051920 peroxiredoxin activity -- -- -- -- Cluster-8309.37307 BP_3 381.00 134.06 428 350646286 CCD59012.1 288 1.1e-23 saposin containing protein [Schistosoma mansoni] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37308 BP_3 12023.05 72.84 8248 642931063 XP_008196196.1 1688 9.9e-185 PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|642931065|ref|XP_008196197.1| PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|270011892|gb|EFA08340.1| hypothetical protein TcasGA2_TC005983 [Tribolium castaneum] 195484142 XM_002090535.1 90 3.50437e-36 Drosophila yakuba RpS26 (Dyak\RpS26), partial mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 Q9GT45 503 1.0e-48 40S ribosomal protein S26 OS=Anopheles gambiae GN=RpS26 PE=3 SV=2 PF06156//PF04977//PF15473//PF13851//PF01283 Protein of unknown function (DUF972)//Septum formation initiator//PEST, proteolytic signal-containing nuclear protein family//Growth-arrest specific micro-tubule binding//Ribosomal protein S26e GO:0042254//GO:0007049//GO:0006260//GO:0016567//GO:0048870//GO:0006412 ribosome biogenesis//cell cycle//DNA replication//protein ubiquitination//cell motility//translation GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0031514 intracellular//ribosome//motile cilium KOG1768 40s ribosomal protein S26 Cluster-8309.37309 BP_3 522.59 5.05 5276 642918013 XP_008198979.1 1028 2.1e-108 PREDICTED: cytochrome c1, heme protein, mitochondrial [Tribolium castaneum]>gi|270004913|gb|EFA01361.1| mitochondrial cytochrome c1 [Tribolium castaneum] -- -- -- -- -- K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 744 7.5e-77 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF00034//PF13442//PF02167 Cytochrome c//Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome C1 family GO:0006118 obsolete electron transport GO:0020037//GO:0005488//GO:0009055 heme binding//binding//electron carrier activity -- -- KOG3052 Cytochrome c1 Cluster-8309.37310 BP_3 1350.83 33.15 2256 91095261 XP_973714.1 857 6.2e-89 PREDICTED: transmembrane emp24 domain-containing protein bai [Tribolium castaneum]>gi|642940176|ref|XP_008200551.1| PREDICTED: transmembrane emp24 domain-containing protein bai [Tribolium castaneum]>gi|270017048|gb|EFA13494.1| hypothetical protein TcasGA2_TC016304 [Tribolium castaneum] 346709726 AK385774.1 66 2.08239e-23 Bombyx mori mRNA, clone: fphe08C16 -- -- -- -- B4GE47 756 1.3e-78 Transmembrane emp24 domain-containing protein bai OS=Drosophila persimilis GN=bai PE=3 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1691 emp24/gp25L/p24 family of membrane trafficking proteins Cluster-8309.37311 BP_3 4407.19 50.83 4471 270014227 EFA10675.1 4152 0.0e+00 kinesin heavy chain [Tribolium castaneum] 642936643 XM_008200299.1 908 0 PREDICTED: Tribolium castaneum kinesin 1 (LOC662208), mRNA K10396 KIF5 kinesin family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10396 P17210 3478 0.0e+00 Kinesin heavy chain OS=Drosophila melanogaster GN=Khc PE=1 SV=2 PF08702//PF15461//PF01601//PF00225 Fibrinogen alpha/beta chain family//Beta-carotene 15,15'-dioxygenase//Coronavirus S2 glycoprotein//Kinesin motor domain GO:0061025//GO:0030168//GO:0046813//GO:0007017//GO:0055114//GO:0007018//GO:0007165//GO:0051258 membrane fusion//platelet activation//receptor-mediated virion attachment to host cell//microtubule-based process//oxidation-reduction process//microtubule-based movement//signal transduction//protein polymerization GO:0030674//GO:0008017//GO:0003777//GO:0005102//GO:0005524//GO:0016702 protein binding, bridging//microtubule binding//microtubule motor activity//receptor binding//ATP binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005874//GO:0019031//GO:0005577//GO:0016021//GO:0045298 microtubule//viral envelope//fibrinogen complex//integral component of membrane//tubulin complex KOG0240 Kinesin (SMY1 subfamily) Cluster-8309.37312 BP_3 114.55 2.64 2387 731463707 XP_003407411.2 642 5.6e-64 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100675838 [Loxodonta africana] 642923856 XM_008195686.1 201 1.98319e-98 PREDICTED: Tribolium castaneum uncharacterized LOC663851 (LOC663851), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 603 7.6e-61 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13912//PF07776//PF13465//PF00096//PF01155//PF07975 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TFIIH C1-like domain GO:0006464//GO:0006281 cellular protein modification process//DNA repair GO:0008270//GO:0016151//GO:0046872 zinc ion binding//nickel cation binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.37313 BP_3 434.03 13.45 1847 91091570 XP_967396.1 2526 1.5e-282 PREDICTED: pre-mRNA-processing factor 17 [Tribolium castaneum]>gi|270001029|gb|EEZ97476.1| hypothetical protein TcasGA2_TC011310 [Tribolium castaneum] 801386190 XM_012201009.1 177 3.35437e-85 PREDICTED: Atta cephalotes pre-mRNA-processing factor 17 (LOC105619494), mRNA K12816 CDC40, PRP17 pre-mRNA-processing factor 17 http://www.genome.jp/dbget-bin/www_bget?ko:K12816 Q9DC48 1983 5.6e-221 Pre-mRNA-processing factor 17 OS=Mus musculus GN=Cdc40 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0282 mRNA splicing factor Cluster-8309.37314 BP_3 571.38 14.99 2129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895 Signal transducing histidine kinase, homodimeric domain GO:0016310//GO:0000160//GO:0006935 phosphorylation//phosphorelay signal transduction system//chemotaxis GO:0000155//GO:0004673 phosphorelay sensor kinase activity//protein histidine kinase activity GO:0005737//GO:0009365 cytoplasm//protein histidine kinase complex -- -- Cluster-8309.37315 BP_3 26.82 0.50 2873 642922794 XP_008193328.1 2003 1.0e-221 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 5.2e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF11965//PF06905//PF08496//PF03357 Domain of unknown function (DUF3479)//Fas apoptotic inhibitory molecule (FAIM1)//Peptidase family S49 N-terminal//Snf7 GO:0043066//GO:0007034//GO:0015994 negative regulation of apoptotic process//vacuolar transport//chlorophyll metabolic process GO:0004252//GO:0016851 serine-type endopeptidase activity//magnesium chelatase activity GO:0010007//GO:0005886 magnesium chelatase complex//plasma membrane -- -- Cluster-8309.37316 BP_3 313.12 4.68 3519 642936430 XP_008198431.1 1296 1.2e-139 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X3 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.16588e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q6GPZ1 438 1.5e-41 RISC-loading complex subunit tarbp2 OS=Xenopus laevis GN=tarbp2 PE=2 SV=2 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.37317 BP_3 231.59 3.79 3236 859132811 AKO63319.1 3478 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2391 4.8e-268 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF02460//PF00487//PF00368 Patched family//Fatty acid desaturase//Hydroxymethylglutaryl-coenzyme A reductase GO:0007165//GO:0006629//GO:0015936//GO:0055114//GO:0006694 signal transduction//lipid metabolic process//coenzyme A metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0050662//GO:0008158//GO:0004420 coenzyme binding//hedgehog receptor activity//hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0016020 membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.37319 BP_3 66.86 2.67 1501 665812915 XP_008554994.1 1196 2.0e-128 PREDICTED: uncharacterized protein LOC103576525 isoform X6 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P13678 128 5.8e-06 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF00168//PF09202 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain//Rio2, N-terminal GO:0009069//GO:0035556//GO:0006468//GO:0016310 serine family amino acid metabolic process//intracellular signal transduction//protein phosphorylation//phosphorylation GO:0005515//GO:0004674//GO:0005524 protein binding//protein serine/threonine kinase activity//ATP binding -- -- -- -- Cluster-8309.37323 BP_3 140.84 2.47 3038 91086463 XP_969857.1 1953 6.8e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1236 3.9e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF00335//PF03188 Tetraspanin family//Eukaryotic cytochrome b561 -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.37324 BP_3 1231.15 27.74 2431 91079832 XP_970236.1 693 6.9e-70 PREDICTED: protein enabled isoform X1 [Tribolium castaneum]>gi|270003288|gb|EEZ99735.1| hypothetical protein TcasGA2_TC002504 [Tribolium castaneum] 642918238 XM_008193203.1 203 1.56178e-99 PREDICTED: Tribolium castaneum protein enabled (LOC658784), transcript variant X2, mRNA K05746 ENAH, MENA enabled http://www.genome.jp/dbget-bin/www_bget?ko:K05746 Q8T4F7 462 1.7e-44 Protein enabled OS=Drosophila melanogaster GN=ena PE=1 SV=4 PF00638//PF12235 RanBP1 domain//Fragile X-related 1 protein core C terminal GO:0046907 intracellular transport GO:0003723 RNA binding -- -- KOG4590 Signal transduction protein Enabled, contains WH1 domain Cluster-8309.37325 BP_3 1012.00 35.26 1675 642914789 XP_008190353.1 352 1.7e-30 PREDICTED: glutamic acid-rich protein [Tribolium castaneum]>gi|270002301|gb|EEZ98748.1| hypothetical protein TcasGA2_TC001306 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82970 153 8.1e-09 High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens GN=HMGN5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37326 BP_3 52.85 1.62 1867 478256018 ENN76217.1 2067 2.5e-229 hypothetical protein YQE_07184, partial [Dendroctonus ponderosae] 158295753 XM_001688807.1 230 1.16907e-114 Anopheles gambiae str. PEST AGAP006366-PD (AgaP_AGAP006366) mRNA, complete cds K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q6P6Z8 1423 4.9e-156 2-oxoglutarate dehydrogenase, mitochondrial OS=Xenopus laevis GN=ogdh PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.37327 BP_3 2538.03 14.65 8644 642934775 XP_008197803.1 5053 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 436 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 2332 9.0e-261 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.37328 BP_3 899.62 21.21 2336 91087367 XP_975633.1 885 3.6e-92 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XJA3 341 1.8e-30 Protein PRRC1 OS=Danio rerio GN=prrc1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37331 BP_3 2974.78 12.40 11853 91092426 XP_968165.1 5142 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC1 [Tribolium castaneum]>gi|270004743|gb|EFA01191.1| hypothetical protein TcasGA2_TC010518 [Tribolium castaneum] 617460781 XM_007571860.1 414 0 PREDICTED: Poecilia formosa ATP-binding cassette, sub-family E (OABP), member 1 (abce1), mRNA K03018 RPC1, POLR3A DNA-directed RNA polymerase III subunit RPC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03018 Q5ZL98 3717 0.0e+00 DNA-directed RNA polymerase III subunit RPC1 OS=Gallus gallus GN=POLR3A PE=2 SV=1 PF00005//PF03193//PF00910//PF07851//PF07352//PF00448//PF01084//PF01920//PF06810//PF04997//PF02367//PF00623//PF04998//PF00931//PF13304//PF07728//PF08477//PF04983//PF05000//PF00004 ABC transporter//Protein of unknown function, DUF258//RNA helicase//TMPIT-like protein//Bacteriophage Mu Gam like protein//SRP54-type protein, GTPase domain//Ribosomal protein S18//Prefoldin subunit//Phage minor structural protein GP20//RNA polymerase Rpb1, domain 1//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 5//NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 4//ATPase family associated with various cellular activities (AAA) GO:0042254//GO:0006614//GO:0007264//GO:0006206//GO:0002949//GO:0006412//GO:0006144//GO:0006457//GO:0042262//GO:0006351 ribosome biogenesis//SRP-dependent cotranslational protein targeting to membrane//small GTPase mediated signal transduction//pyrimidine nucleobase metabolic process//tRNA threonylcarbamoyladenosine modification//translation//purine nucleobase metabolic process//protein folding//DNA protection//transcription, DNA-templated GO:0016887//GO:0008270//GO:0051082//GO:0003735//GO:0003924//GO:0005198//GO:0005524//GO:0003899//GO:0003724//GO:0003690//GO:0005525//GO:0043531//GO:0032549//GO:0003677//GO:0003723 ATPase activity//zinc ion binding//unfolded protein binding//structural constituent of ribosome//GTPase activity//structural molecule activity//ATP binding//DNA-directed RNA polymerase activity//RNA helicase activity//double-stranded DNA binding//GTP binding//ADP binding//ribonucleoside binding//DNA binding//RNA binding GO:0016272//GO:0005730//GO:0005622//GO:0005840//GO:0016021//GO:0005634 prefoldin complex//nucleolus//intracellular//ribosome//integral component of membrane//nucleus KOG0261 RNA polymerase III, large subunit Cluster-8309.37332 BP_3 564.28 14.07 2225 332373744 AEE62013.1 291 2.6e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5EF78 135 1.3e-06 Icarapin OS=Apis mellifera carnica PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37333 BP_3 89.77 0.93 4935 91085983 XP_972029.1 1876 9.4e-207 PREDICTED: TBC1 domain family member 31 [Tribolium castaneum]>gi|270010179|gb|EFA06627.1| hypothetical protein TcasGA2_TC009546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DN5 1034 1.7e-110 TBC1 domain family member 31 OS=Homo sapiens GN=TBC1D31 PE=2 SV=2 PF03091//PF00156//PF03310//PF06689 CutA1 divalent ion tolerance protein//Phosphoribosyl transferase domain//Caulimovirus DNA-binding protein//ClpX C4-type zinc finger GO:0010038//GO:0009116 response to metal ion//nucleoside metabolic process GO:0046983//GO:0008270//GO:0003677 protein dimerization activity//zinc ion binding//DNA binding -- -- KOG1712 Adenine phosphoribosyl transferases Cluster-8309.37334 BP_3 1579.50 9.83 8040 546673207 ERL84861.1 1263 1.8e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.1e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF03824//PF03193//PF00005//PF15458//PF00503//PF17078//PF02183//PF04548//PF06156//PF06005//PF00437//PF00312//PF01066//PF05529 High-affinity nickel-transport protein//Protein of unknown function, DUF258//ABC transporter//Nineteen complex-related protein 2//G-protein alpha subunit//SWI5-dependent HO expression protein 3//Homeobox associated leucine zipper//AIG1 family//Protein of unknown function (DUF972)//Protein of unknown function (DUF904)//Type II/IV secretion system protein//Ribosomal protein S15//CDP-alcohol phosphatidyltransferase//B-cell receptor-associated protein 31-like GO:0006260//GO:0035444//GO:0042254//GO:0048309//GO:0051028//GO:0007186//GO:0000390//GO:0006355//GO:0015675//GO:0007165//GO:0006886//GO:0006810//GO:0008654//GO:0000917//GO:0043093//GO:0006412 DNA replication//nickel cation transmembrane transport//ribosome biogenesis//endoplasmic reticulum inheritance//mRNA transport//G-protein coupled receptor signaling pathway//spliceosomal complex disassembly//regulation of transcription, DNA-templated//nickel cation transport//signal transduction//intracellular protein transport//transport//phospholipid biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis//translation GO:0016887//GO:0019001//GO:0003735//GO:0003700//GO:0031683//GO:0005524//GO:0003924//GO:0046872//GO:0043565//GO:0004871//GO:0015099//GO:0005525//GO:0016780 ATPase activity//guanyl nucleotide binding//structural constituent of ribosome//transcription factor activity, sequence-specific DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//metal ion binding//sequence-specific DNA binding//signal transducer activity//nickel cation transmembrane transporter activity//GTP binding//phosphotransferase activity, for other substituted phosphate groups GO:0071008//GO:0005667//GO:0005622//GO:0005840//GO:0005737//GO:0016021//GO:0016020//GO:0005783 U2-type post-mRNA release spliceosomal complex//transcription factor complex//intracellular//ribosome//cytoplasm//integral component of membrane//membrane//endoplasmic reticulum KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.37335 BP_3 22.59 0.71 1830 33112583 AAP94047.1 1363 1.1e-147 cathepsin-L-like cysteine peptidase 03 [Tenebrio molitor] 33112582 AY332271.1 234 6.8453e-117 Tenebrio molitor cathepsin-L-like cysteine peptidase 03 mRNA, complete cds K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 1201 2.7e-130 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37336 BP_3 266.25 2.72 5011 642936624 XP_008198511.1 2306 1.3e-256 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37337 BP_3 3.00 0.37 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37339 BP_3 15.00 0.46 1852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37340 BP_3 60.22 1.10 2926 642924318 XP_008194246.1 790 4.7e-81 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 264 1.9e-21 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 -- -- GO:0006811 ion transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.37341 BP_3 4129.32 38.58 5451 478254120 ENN74402.1 4180 0.0e+00 hypothetical protein YQE_08987, partial [Dendroctonus ponderosae] 156845530 XM_001645606.1 61 3.05464e-20 Vanderwaltozyma polyspora DSM 70294 hypothetical protein (Kpol_541p40) partial mRNA K12618 XRN1, SEP1, KEM1 5'-3' exoribonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12618 P97789 2893 0.0e+00 5'-3' exoribonuclease 1 OS=Mus musculus GN=Xrn1 PE=1 SV=1 PF03159 XRN 5'-3' exonuclease N-terminus -- -- GO:0004527//GO:0003676 exonuclease activity//nucleic acid binding -- -- KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover Cluster-8309.37342 BP_3 617.52 6.90 4604 91093150 XP_970085.1 3501 0.0e+00 PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X1 [Tribolium castaneum]>gi|270003008|gb|EEZ99455.1| hypothetical protein TcasGA2_TC000021 [Tribolium castaneum] 795078999 XM_012021559.1 166 1.10131e-78 PREDICTED: Vollenhovia emeryi ribosomal protein S6 kinase alpha-5 (LOC105567037), transcript variant X2, mRNA K04445 MSK1, RPS6KA5 ribosomal protein S6 kinase alpha-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04445 O75582 2215 1.8e-247 Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens GN=RPS6KA5 PE=1 SV=1 PF00433//PF07714//PF06293//PF00069 Protein kinase C terminal domain//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.37343 BP_3 1953.06 8.81 10972 642922880 XP_008200435.1 6092 0.0e+00 PREDICTED: maestro heat-like repeat-containing protein family member 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDA8 1449 2.8e-158 Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens GN=MROH1 PE=2 SV=3 PF00628//PF01429//PF02985//PF05485//PF00096//PF07178//PF11698 PHD-finger//Methyl-CpG binding domain//HEAT repeat//THAP domain//Zinc finger, C2H2 type//TraL protein//V-ATPase subunit H GO:0000746//GO:0015991 conjugation//ATP hydrolysis coupled proton transport GO:0046872//GO:0003676//GO:0005515//GO:0016820//GO:0003677 metal ion binding//nucleic acid binding//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//DNA binding GO:0000221//GO:0019867//GO:0005634 vacuolar proton-transporting V-type ATPase, V1 domain//outer membrane//nucleus KOG2032 Uncharacterized conserved protein Cluster-8309.37344 BP_3 349.96 4.01 4503 189237587 XP_975066.2 695 7.5e-70 PREDICTED: nuclear cap-binding protein subunit 2 [Tribolium castaneum] 755860540 XM_005178495.2 76 1.15591e-28 PREDICTED: Musca domestica nuclear cap-binding protein subunit 2B (LOC101888112), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 629 1.4e-63 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.37345 BP_3 2688.81 165.46 1075 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37346 BP_3 393.34 2.90 6830 332376178 AEE63229.1 915 3.5e-95 unknown [Dendroctonus ponderosae] 642924593 XM_008196134.1 241 3.32536e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.3e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.37348 BP_3 779.27 6.12 6429 91081951 XP_967254.1 2000 5.1e-221 PREDICTED: LIM domain-containing protein jub isoform X2 [Tribolium castaneum]>gi|270007323|gb|EFA03771.1| hypothetical protein TcasGA2_TC013882 [Tribolium castaneum] 170045329 XM_001850215.1 286 3.02031e-145 Culex quinquefasciatus limd1, mRNA K16682 AJUBA, LIMD1, WTIP LIM domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K16682 Q9VY77 1200 1.2e-129 LIM domain-containing protein jub OS=Drosophila melanogaster GN=jub PE=1 SV=3 PF00412//PF00400 LIM domain//WD domain, G-beta repeat -- -- GO:0043169//GO:0008270//GO:0005515 cation binding//zinc ion binding//protein binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.37349 BP_3 47.85 0.60 4149 642929336 XP_008195791.1 1307 7.5e-141 PREDICTED: AMP deaminase 2 isoform X2 [Tribolium castaneum] 194769475 XM_001966794.1 279 1.51352e-141 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 968 6.3e-103 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0019239//GO:0016491//GO:0046872 deaminase activity//oxidoreductase activity//metal ion binding -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.3735 BP_3 12.68 0.61 1291 270014288 EFA10736.1 849 3.0e-88 hypothetical protein TcasGA2_TC012368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37350 BP_3 30.16 0.45 3546 642929336 XP_008195791.1 1885 6.1e-208 PREDICTED: AMP deaminase 2 isoform X2 [Tribolium castaneum] 194769475 XM_001966794.1 279 1.29162e-141 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q02356 1080 5.5e-116 AMP deaminase 2 OS=Rattus norvegicus GN=Ampd2 PE=2 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0019239//GO:0016491//GO:0046872 deaminase activity//oxidoreductase activity//metal ion binding -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.37351 BP_3 84.17 0.39 10739 91080713 XP_975329.1 4737 0.0e+00 PREDICTED: leucine-rich PPR motif-containing protein, mitochondrial [Tribolium castaneum]>gi|270005471|gb|EFA01919.1| hypothetical protein TcasGA2_TC007529 [Tribolium castaneum] -- -- -- -- -- K17964 LRPPRC leucine-rich PPR motif-containing protein, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17964 P42704 1298 8.8e-141 Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens GN=LRPPRC PE=1 SV=3 PF13181//PF09246//PF07647//PF00014//PF00536//PF00515//PF13414//PF00637 Tetratricopeptide repeat//PHAT//SAM domain (Sterile alpha motif)//Kunitz/Bovine pancreatic trypsin inhibitor domain//SAM domain (Sterile alpha motif)//Tetratricopeptide repeat//TPR repeat//Region in Clathrin and VPS GO:0006355//GO:0016192//GO:0006886 regulation of transcription, DNA-templated//vesicle-mediated transport//intracellular protein transport GO:0003723//GO:0005515//GO:0004867 RNA binding//protein binding//serine-type endopeptidase inhibitor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.37352 BP_3 191.10 1.20 7989 642935409 XP_008197998.1 2686 1.8e-300 PREDICTED: actin-binding LIM protein 3 isoform X1 [Tribolium castaneum]>gi|270013886|gb|EFA10334.1| hypothetical protein TcasGA2_TC012552 [Tribolium castaneum] 808119259 XM_012307759.1 168 1.48159e-79 PREDICTED: Bombus terrestris ras-GEF domain-containing family member 1B-like (LOC100645439), transcript variant X2, mRNA -- -- -- -- Q6DHR3 1308 4.6e-142 Ras-GEF domain-containing family member 1B-A OS=Danio rerio GN=rasgef1ba PE=2 SV=2 PF00617//PF00412//PF13639 RasGEF domain//LIM domain//Ring finger domain GO:0007010//GO:0043087//GO:0007264 cytoskeleton organization//regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085//GO:0005515//GO:0003779//GO:0008270//GO:0046872 guanyl-nucleotide exchange factor activity//protein binding//actin binding//zinc ion binding//metal ion binding -- -- KOG3541 Predicted guanine nucleotide exchange factor Cluster-8309.37353 BP_3 55.52 0.49 5762 91083171 XP_972171.1 2439 5.7e-272 PREDICTED: mRNA-capping enzyme [Tribolium castaneum]>gi|270006979|gb|EFA03427.1| hypothetical protein TcasGA2_TC013414 [Tribolium castaneum] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 O55236 1662 2.9e-183 mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1 PF01331//PF00102//PF00782//PF03919//PF15182 mRNA capping enzyme, catalytic domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//mRNA capping enzyme, C-terminal domain//Otospiralin GO:0006370//GO:0035335//GO:0006397//GO:0006470//GO:0006570//GO:0007605 7-methylguanosine mRNA capping//peptidyl-tyrosine dephosphorylation//mRNA processing//protein dephosphorylation//tyrosine metabolic process//sensory perception of sound GO:0004651//GO:0008138//GO:0004484//GO:0004725 polynucleotide 5'-phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//mRNA guanylyltransferase activity//protein tyrosine phosphatase activity GO:0005634 nucleus KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.37355 BP_3 392.43 11.16 1987 91083175 XP_972331.1 1160 4.0e-124 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 785 5.0e-82 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 PF15182 Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.37357 BP_3 47.80 0.32 7531 642928597 XP_008199971.1 5686 0.0e+00 PREDICTED: autophagy-related protein 2 homolog A isoform X3 [Tribolium castaneum] -- -- -- -- -- K17906 ATG2 autophagy-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17906 Q80XK6 2087 2.0e-232 Autophagy-related protein 2 homolog B OS=Mus musculus GN=Atg2b PE=1 SV=3 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG2993 Cytoplasm to vacuole targeting protein Cluster-8309.37358 BP_3 403.18 4.58 4539 642934410 XP_008197649.1 1989 6.8e-220 PREDICTED: transport and Golgi organization protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VMA7 461 4.2e-44 Transport and Golgi organization protein 1 OS=Drosophila melanogaster GN=Tango1 PE=1 SV=2 PF00734//PF00038//PF05791 Fungal cellulose binding domain//Intermediate filament protein//Bacillus haemolytic enterotoxin (HBL) GO:0009405//GO:0005975 pathogenesis//carbohydrate metabolic process GO:0004553//GO:0030248//GO:0005198 hydrolase activity, hydrolyzing O-glycosyl compounds//cellulose binding//structural molecule activity GO:0005882//GO:0016020//GO:0005576 intermediate filament//membrane//extracellular region -- -- Cluster-8309.37361 BP_3 916.00 35.92 1521 91088257 XP_966746.1 2123 6.6e-236 PREDICTED: 26S proteasome non-ATPase regulatory subunit 12 [Tribolium castaneum]>gi|270012153|gb|EFA08601.1| hypothetical protein TcasGA2_TC006260 [Tribolium castaneum] -- -- -- -- -- K03035 PSMD12, RPN5 26S proteasome regulatory subunit N5 http://www.genome.jp/dbget-bin/www_bget?ko:K03035 Q9D8W5 1509 4.3e-166 26S proteasome non-ATPase regulatory subunit 12 OS=Mus musculus GN=Psmd12 PE=1 SV=4 PF07988//PF01397//PF01399 LMSTEN motif//Terpene synthase, N-terminal domain//PCI domain GO:0006355//GO:0008152 regulation of transcription, DNA-templated//metabolic process GO:0005515//GO:0016829//GO:0010333 protein binding//lyase activity//terpene synthase activity -- -- KOG1498 26S proteasome regulatory complex, subunit RPN5/PSMD12 Cluster-8309.37362 BP_3 28657.00 1403.33 1276 556505470 YP_008757567.1 1591 2.7e-174 cytochrome b (mitochondrion) [Batocera lineolata]>gi|359294293|gb|AEV21662.1| cytochrome b [Batocera lineolata] 359294281 JN986793.1 882 0 Batocera lineolata mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 Q8WBV2 1285 3.4e-140 Cytochrome b OS=Ostrinia nubilalis GN=MT-CYB PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4663 Cytochrome b Cluster-8309.37364 BP_3 2348.19 55.28 2339 826467549 XP_012535467.1 2245 7.2e-250 PREDICTED: glutamate dehydrogenase, mitochondrial [Monomorium pharaonis] 817214513 XM_012428072.1 262 2.39164e-132 PREDICTED: Orussus abietinus glutamate dehydrogenase, mitochondrial (LOC105701373), mRNA K00261 GLUD1_2, gdhA glutamate dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00261 P54385 2080 4.0e-232 Glutamate dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=Gdh PE=1 SV=2 PF00208//PF02812//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Glu/Leu/Phe/Val dehydrogenase, dimerisation domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0006520 oxidation-reduction process//cellular amino acid metabolic process GO:0051287//GO:0016491 NAD binding//oxidoreductase activity -- -- KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases Cluster-8309.37365 BP_3 2674.65 26.23 5206 270011586 EFA08034.1 1458 2.9e-158 hypothetical protein TcasGA2_TC005623 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 Q1JPA0 1157 9.6e-125 Aldehyde dehydrogenase family 3 member B1 OS=Bos taurus GN=ALDH3B1 PE=2 SV=1 PF00171//PF07966 Aldehyde dehydrogenase family//A1 Propeptide GO:0006508//GO:0008152//GO:0055114 proteolysis//metabolic process//oxidation-reduction process GO:0004190//GO:0016491 aspartic-type endopeptidase activity//oxidoreductase activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.37366 BP_3 12.00 15.55 317 642922794 XP_008193328.1 402 5.0e-37 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 253 3.9e-21 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 PF06448 Domain of Unknown Function (DUF1081) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- -- -- Cluster-8309.37367 BP_3 5911.98 149.40 2199 91077280 XP_974370.1 319 1.5e-26 PREDICTED: uncharacterized protein LOC663220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37368 BP_3 26.02 0.35 3835 270002078 EEZ98525.1 254 8.8e-19 hypothetical protein TcasGA2_TC001029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3737 BP_3 38.91 5.40 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37370 BP_3 152.02 1.07 7161 642934549 XP_008197710.1 1789 1.7e-196 PREDICTED: axoneme-associated protein mst101(2)-like isoform X2 [Tribolium castaneum] 768421079 XM_011553033.1 246 5.7945e-123 PREDICTED: Plutella xylostella serine/threonine-protein kinase STE20-like (LOC105383024), transcript variant X3, mRNA K06068 PRKCD novel protein kinase C delta type http://www.genome.jp/dbget-bin/www_bget?ko:K06068 P83099 1470 6.7e-161 Putative protein kinase C delta type homolog OS=Drosophila melanogaster GN=Pkcdelta PE=2 SV=3 PF00433//PF07714//PF00069//PF00858 Protein kinase C terminal domain//Protein tyrosine kinase//Protein kinase domain//Amiloride-sensitive sodium channel GO:0006814//GO:0006468//GO:0009069//GO:0016310 sodium ion transport//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005272//GO:0004674//GO:0004672//GO:0005524 sodium channel activity//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.37378 BP_3 81.72 0.86 4871 576249472 AHH29250.1 2669 1.0e-298 Bedraggled-like protein [Leptinotarsa decemlineata] 576249471 KC713792.1 587 0 Leptinotarsa decemlineata Bedraggled-like protein mRNA, complete cds K05336 SLC6AN solute carrier family 6 (neurotransmitter transporter), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05336 Q99884 256 2.7e-20 Sodium-dependent proline transporter OS=Homo sapiens GN=SLC6A7 PE=2 SV=2 PF11421//PF00209 ATP synthase F1 beta subunit//Sodium:neurotransmitter symporter family GO:0006754//GO:0006812//GO:0006836 ATP biosynthetic process//cation transport//neurotransmitter transport GO:0016887//GO:0005328//GO:0005524 ATPase activity//neurotransmitter:sodium symporter activity//ATP binding GO:0000275//GO:0016021 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//integral component of membrane -- -- Cluster-8309.37379 BP_3 562.44 5.92 4871 91087973 XP_973205.1 2198 4.2e-244 PREDICTED: probable ribonuclease ZC3H12D isoform X1 [Tribolium castaneum] 642931021 XM_968112.2 306 1.74184e-156 PREDICTED: Tribolium castaneum probable ribonuclease ZC3H12B (LOC661984), transcript variant X1, mRNA K18668 ZC3H12, MCPIP ribonuclease ZC3H12 http://www.genome.jp/dbget-bin/www_bget?ko:K18668 Q5DTV4 843 2.3e-88 Probable ribonuclease ZC3H12C OS=Mus musculus GN=Zc3h12c PE=2 SV=2 PF07499//PF05157//PF00642 RuvA, C-terminal domain//Type II secretion system (T2SS), protein E, N-terminal domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006310//GO:0006281//GO:0006810 DNA recombination//DNA repair//transport GO:0046872//GO:0009378//GO:0005524 metal ion binding//four-way junction helicase activity//ATP binding GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG3777 Uncharacterized conserved protein Cluster-8309.37381 BP_3 55.59 0.72 3999 270005574 EFA02022.1 1711 1.0e-187 hypothetical protein TcasGA2_TC007647 [Tribolium castaneum] 642919114 XM_008193522.1 141 7.5445e-65 PREDICTED: Tribolium castaneum DDB1- and CUL4-associated factor 8 (LOC656756), mRNA K11804 WDR42A WD repeat-containing protein 42A http://www.genome.jp/dbget-bin/www_bget?ko:K11804 Q5TAQ9 992 1.0e-105 DDB1- and CUL4-associated factor 8 OS=Homo sapiens GN=DCAF8 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1334 WD40 repeat protein Cluster-8309.37382 BP_3 872.99 2.67 16023 546683698 ERL93476.1 2777 1.3e-310 hypothetical protein D910_10767, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535//PF00096 DBF zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.37383 BP_3 7247.81 24.22 14715 642918534 XP_008191512.1 19331 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 3183 0 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 15785 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02480//PF13895//PF14980 Alphaherpesvirus glycoprotein E//Immunoglobulin domain//TIP39 peptide GO:0007218 neuropeptide signaling pathway GO:0005515 protein binding GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.37385 BP_3 661.04 6.25 5392 642911787 XP_008200742.1 4674 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X3 [Tribolium castaneum] 642911788 XM_967563.3 511 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 O15021 2207 1.7e-246 Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens GN=MAST4 PE=1 SV=3 PF08926//PF00595//PF00069//PF06293//PF13180//PF07714 Domain of unknown function (DUF1908)//PDZ domain (Also known as DHR or GLGF)//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PDZ domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0004674//GO:0000287//GO:0016773 protein binding//ATP binding//protein kinase activity//protein serine/threonine kinase activity//magnesium ion binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.37388 BP_3 23.16 0.33 3687 288869514 NP_001165864.1 2496 8.9e-279 extended synaptotagmin-like protein 2a [Tribolium castaneum]>gi|642923659|ref|XP_008193831.1| PREDICTED: extended synaptotagmin-like protein 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0FGR8 952 4.0e-101 Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2 PE=1 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.3739 BP_3 9.10 0.33 1636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16422 Transcription factor COE1 DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.37390 BP_3 191.11 1.54 6290 642915997 XP_008190849.1 3607 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 306 2.25198e-156 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 919 4.6e-97 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF00041//PF13895//PF16656//PF02480//PF07714//PF00069//PF06293 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006771//GO:0019497//GO:0006468 riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0003993//GO:0016773//GO:0004672//GO:0046872//GO:0005524//GO:0005515 acid phosphatase activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//metal ion binding//ATP binding//protein binding GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.37391 BP_3 1402.00 33.60 2303 189234874 XP_973619.2 1312 1.1e-141 PREDICTED: cytochrome P450 9e2 [Tribolium castaneum]>gi|270002740|gb|EEZ99187.1| cytochrome P450 9AD1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1040 1.6e-111 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0016705//GO:0005488 heme binding//iron ion binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding -- -- -- -- Cluster-8309.37392 BP_3 84.52 1.39 3218 91090103 XP_970810.1 2084 4.6e-231 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 195386227 XM_002051770.1 107 4.81729e-46 Drosophila virilis GJ17194 (Dvir\GJ17194), mRNA -- -- -- -- Q96PX1 1035 8.3e-111 RING finger protein 157 OS=Homo sapiens GN=RNF157 PE=1 SV=3 PF13639//PF03544//PF03854//PF00252//PF14634 Ring finger domain//Gram-negative bacterial TonB protein C-terminal//P-11 zinc finger//Ribosomal protein L16p/L10e//zinc-RING finger domain GO:0042254//GO:0006412//GO:0006810 ribosome biogenesis//translation//transport GO:0003735//GO:0008270//GO:0043169//GO:0003723//GO:0005515 structural constituent of ribosome//zinc ion binding//cation binding//RNA binding//protein binding GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.37394 BP_3 9190.00 1602.90 568 264667407 ACY71289.1 505 1.0e-48 ribosomal protein L31 [Chrysomela tremula] 749782899 XM_011147233.1 95 3.79035e-40 PREDICTED: Harpegnathos saltator 60S ribosomal protein L31 (LOC105186788), transcript variant X2, mRNA K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 Q9GP16 463 3.1e-45 60S ribosomal protein L31 OS=Heliothis virescens GN=RpL31 PE=2 SV=1 PF01198 Ribosomal protein L31e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0893 60S ribosomal protein L31 Cluster-8309.37395 BP_3 103.89 0.65 7949 332375078 AEE62680.1 1234 4.2e-132 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14457 MOGAT2, MGAT2 2-acylglycerol O-acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14457 Q70VZ7 681 2.3e-69 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982//PF01781 Diacylglycerol acyltransferase//Ribosomal L38e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0016747 structural constituent of ribosome//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005840//GO:0005622 ribosome//intracellular KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.37396 BP_3 1539.80 31.56 2643 91092648 XP_969941.1 1980 4.4e-219 PREDICTED: tyrosine-protein kinase Drl [Tribolium castaneum]>gi|270014831|gb|EFA11279.1| hypothetical protein TcasGA2_TC010814 [Tribolium castaneum] -- -- -- -- -- K05128 RYK RYK receptor-like tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05128 Q9V422 1277 5.9e-139 Tyrosine-protein kinase Dnt OS=Drosophila melanogaster GN=dnt PE=2 SV=2 PF07714//PF02198//PF00069 Protein tyrosine kinase//Sterile alpha motif (SAM)/Pointed domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0004713//GO:0043565//GO:0005524//GO:0004672 protein tyrosine kinase activity//sequence-specific DNA binding//ATP binding//protein kinase activity GO:0005634 nucleus KOG1024 Receptor-like protein tyrosine kinase RYK/derailed Cluster-8309.37397 BP_3 198.25 1.75 5746 91083171 XP_972171.1 2439 5.7e-272 PREDICTED: mRNA-capping enzyme [Tribolium castaneum]>gi|270006979|gb|EFA03427.1| hypothetical protein TcasGA2_TC013414 [Tribolium castaneum] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 O55236 1662 2.9e-183 mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1 PF03919//PF15182//PF00782//PF00102//PF01331 mRNA capping enzyme, C-terminal domain//Otospiralin//Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//mRNA capping enzyme, catalytic domain GO:0006397//GO:0007605//GO:0006470//GO:0006570//GO:0006370//GO:0035335 mRNA processing//sensory perception of sound//protein dephosphorylation//tyrosine metabolic process//7-methylguanosine mRNA capping//peptidyl-tyrosine dephosphorylation GO:0004484//GO:0004725//GO:0008138//GO:0004651 mRNA guanylyltransferase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//polynucleotide 5'-phosphatase activity GO:0005634 nucleus KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.37398 BP_3 3129.55 69.63 2458 91083675 XP_968367.1 2070 1.5e-229 PREDICTED: serine/threonine-protein kinase PINK1, mitochondrial [Tribolium castaneum]>gi|270006820|gb|EFA03268.1| hypothetical protein TcasGA2_TC013202 [Tribolium castaneum] -- -- -- -- -- K05688 PINK1 PTEN induced putative kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05688 Q9BXM7 729 1.9e-75 Serine/threonine-protein kinase PINK1, mitochondrial OS=Homo sapiens GN=PINK1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG4158 BRPK/PTEN-induced protein kinase Cluster-8309.37399 BP_3 2082.00 93.76 1362 642922690 XP_008193282.1 1127 1.8e-120 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X14 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 286 2.5e-24 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF00008//PF13895 EGF-like domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.37403 BP_3 279.72 7.06 2202 189234116 XP_968417.2 320 1.1e-26 PREDICTED: uridine phosphorylase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37404 BP_3 721.94 3.36 10656 642937913 XP_972695.3 1638 8.0e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.5e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37405 BP_3 12.56 0.32 2157 270297178 NP_001161915.1 629 1.6e-62 cuticular protein analogous to peritrophins 3-E [Tribolium castaneum]>gi|268309024|gb|ACY95478.1| cuticular protein analogous to peritrophins 3-E [Tribolium castaneum]>gi|270001058|gb|EEZ97505.1| hypothetical protein TcasGA2_TC011349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8XWX5 163 7.2e-10 Chondroitin proteoglycan 2 OS=Caenorhabditis briggsae GN=cpg-2 PE=3 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.37406 BP_3 395.96 1.81 10816 91090089 XP_975854.1 857 3.0e-88 PREDICTED: protein Tob1 [Tribolium castaneum]>gi|270013495|gb|EFA09943.1| hypothetical protein TcasGA2_TC012096 [Tribolium castaneum] 642934619 XM_970761.2 381 0 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 Q8R5K6 502 1.8e-48 Protein Tob1 OS=Rattus norvegicus GN=Tob1 PE=2 SV=1 PF10766 Multidrug efflux pump-associated protein AcrZ GO:0006855//GO:0015893 drug transmembrane transport//drug transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.37408 BP_3 4974.37 40.56 6203 189236151 XP_974913.2 6311 0.0e+00 PREDICTED: tyrosine-protein phosphatase 10D isoform X3 [Tribolium castaneum] 687022658 LM525572.1 65 2.07897e-22 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_scaffold0000013 K05694 PTPRB, PTPB receptor-type tyrosine-protein phosphatase beta http://www.genome.jp/dbget-bin/www_bget?ko:K05694 P35992 5177 0.0e+00 Tyrosine-protein phosphatase 10D OS=Drosophila melanogaster GN=Ptp10D PE=1 SV=4 PF00102//PF16656//PF00041//PF16794//PF00782 Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Fibronectin-III type domain//Dual specificity phosphatase, catalytic domain GO:0019497//GO:0006570//GO:0006470//GO:0006771 hexachlorocyclohexane metabolic process//tyrosine metabolic process//protein dephosphorylation//riboflavin metabolic process GO:0004725//GO:0008138//GO:0005515//GO:0046872//GO:0003993 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//metal ion binding//acid phosphatase activity -- -- KOG0791 Protein tyrosine phosphatase, contains fn3 domain Cluster-8309.37409 BP_3 64.59 0.49 6642 749791192 XP_011148786.1 1021 1.8e-107 PREDICTED: glycogen synthase kinase-3 beta-like isoform X6 [Harpegnathos saltator] 642920086 XM_008193977.1 215 9.18268e-106 PREDICTED: Tribolium castaneum shaggy (LOC664299), transcript variant X4, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P18431 895 2.9e-94 Protein kinase shaggy OS=Drosophila melanogaster GN=sgg PE=1 SV=3 PF07714//PF14552//PF06293//PF00069 Protein tyrosine kinase//Tautomerase enzyme//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006725//GO:0006468 cellular aromatic compound metabolic process//protein phosphorylation GO:0004672//GO:0016853//GO:0016773//GO:0005524 protein kinase activity//isomerase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0658 Glycogen synthase kinase-3 Cluster-8309.37410 BP_3 2449.31 9.21 13112 642920090 XP_008192200.1 1354 8.4e-146 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920091 XM_970322.3 333 4.60999e-171 PREDICTED: Tribolium castaneum 40S ribosomal protein S2 (LOC664315), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q960X4 1234 2.8e-133 Histone acetyltransferase Tip60 OS=Drosophila melanogaster GN=Tip60 PE=1 SV=1 PF03719//PF13855//PF00560//PF01853//PF00333//PF05261//PF00583//PF13508 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//Leucine Rich Repeat//MOZ/SAS family//Ribosomal protein S5, N-terminal domain//TraM protein, DNA-binding//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0000746//GO:0042254//GO:0006355//GO:0042967//GO:0006412 conjugation//ribosome biogenesis//regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process//translation GO:0016747//GO:0003735//GO:0005515//GO:0008080//GO:0003677//GO:0003723 transferase activity, transferring acyl groups other than amino-acyl groups//structural constituent of ribosome//protein binding//N-acetyltransferase activity//DNA binding//RNA binding GO:0005840//GO:0005634 ribosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.37411 BP_3 900.75 3.95 11289 746835597 XP_011068495.1 2501 7.2e-279 PREDICTED: uncharacterized protein LOC105154570 isoform X8 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q62417 536 2.1e-52 Sorbin and SH3 domain-containing protein 1 OS=Mus musculus GN=Sorbs1 PE=1 SV=2 PF00383//PF14604//PF00595//PF00018//PF13180//PF12549 Cytidine and deoxycytidylate deaminase zinc-binding region//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain//PDZ domain//Tyrosine hydroxylase N terminal GO:0055114//GO:0006570 oxidation-reduction process//tyrosine metabolic process GO:0008270//GO:0004511//GO:0005515 zinc ion binding//tyrosine 3-monooxygenase activity//protein binding -- -- KOG4225 Sorbin and SH3 domain-containing protein Cluster-8309.37412 BP_3 627.53 17.44 2026 642925814 XP_970128.3 661 3.0e-66 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 504 2.0e-49 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.37413 BP_3 222.54 5.09 2401 91076170 XP_971503.1 2162 3.1e-240 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 401 0 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 503 3.0e-49 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.37414 BP_3 38.15 1.60 1443 642925809 XP_969782.3 644 2.0e-64 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 479 1.1e-46 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- -- -- Cluster-8309.37416 BP_3 131.67 2.46 2876 546684533 ERL94164.1 1157 1.3e-123 hypothetical protein D910_11446, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37417 BP_3 57.00 2.12 1586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37419 BP_3 1653.09 20.33 4210 678336953 CDW75723.1 506 5.8e-48 UNKNOWN [Stylonychia lemnae] 375005309 JN619131.1 1869 0 Pogonocherus hispidulus voucher BMNH:835571 18S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37421 BP_3 230.84 5.85 2193 478263359 ENN81735.1 159 5.2e-08 hypothetical protein YQE_01874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37422 BP_3 403.32 5.72 3693 270008954 EFA05402.1 882 1.3e-91 hypothetical protein TcasGA2_TC015574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37425 BP_3 89.84 4.62 1230 307174197 EFN64842.1 147 7.2e-07 hypothetical protein EAG_03612 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37426 BP_3 479.45 2.06 11503 642935534 XP_008198048.1 1716 7.8e-188 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X2 [Tribolium castaneum] 755889203 XM_005188558.2 102 1.04439e-42 PREDICTED: Musca domestica vesicular integral-membrane protein VIP36 (LOC101894935), mRNA K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q7L273 986 1.4e-104 BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens GN=KCTD9 PE=1 SV=1 PF02214//PF02017//PF00139//PF03120//PF03388 BTB/POZ domain//CIDE-N domain//Legume lectin domain//NAD-dependent DNA ligase OB-fold domain//Legume-like lectin family GO:0006260//GO:0006915//GO:0051260//GO:0006281 DNA replication//apoptotic process//protein homooligomerization//DNA repair GO:0030246//GO:0003911 carbohydrate binding//DNA ligase (NAD+) activity GO:0016020//GO:0005622 membrane//intracellular KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.37427 BP_3 1848.07 28.93 3371 288869514 NP_001165864.1 2852 0.0e+00 extended synaptotagmin-like protein 2a [Tribolium castaneum]>gi|642923659|ref|XP_008193831.1| PREDICTED: extended synaptotagmin-like protein 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 964 1.5e-102 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.3743 BP_3 36.50 0.68 2897 189236336 XP_001816307.1 1044 1.6e-110 PREDICTED: general transcription factor IIH subunit 1 [Tribolium castaneum]>gi|270005862|gb|EFA02310.1| hypothetical protein TcasGA2_TC007976 [Tribolium castaneum] -- -- -- -- -- K03141 TFIIH1, GTF2H1, TFB1 transcription initiation factor TFIIH subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03141 Q960E8 891 3.7e-94 General transcription factor IIH subunit 1 OS=Drosophila melanogaster GN=Tfb1 PE=2 SV=1 PF07289 Protein of unknown function (DUF1448) -- -- -- -- GO:0034464 BBSome KOG2074 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB1 Cluster-8309.37430 BP_3 55.94 0.38 7308 662207644 XP_008477334.1 146 5.6e-06 PREDICTED: zinc finger protein 721-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04810//PF00412//PF13912//PF16622//PF00096//PF13465//PF01155 Sec23/Sec24 zinc finger//LIM domain//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006886//GO:0006888 cellular protein modification process//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0046872//GO:0016151 zinc ion binding//metal ion binding//nickel cation binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.37431 BP_3 2205.21 53.97 2261 642910653 XP_968714.2 302 1.4e-24 PREDICTED: polyadenylate-binding protein-interacting protein 2B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37433 BP_3 457.00 38.36 866 91086657 XP_967917.1 873 3.3e-91 PREDICTED: proteasome subunit beta type-2 [Tribolium castaneum]>gi|270009752|gb|EFA06200.1| hypothetical protein TcasGA2_TC009049 [Tribolium castaneum] -- -- -- -- -- K02734 PSMB2 20S proteasome subunit beta 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02734 P40307 656 2.0e-67 Proteasome subunit beta type-2 OS=Rattus norvegicus GN=Psmb2 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005737//GO:0005634//GO:0005839 cytoplasm//nucleus//proteasome core complex KOG0177 20S proteasome, regulatory subunit beta type PSMB2/PRE1 Cluster-8309.37435 BP_3 5685.53 11.50 24116 270014225 EFA10673.1 8598 0.0e+00 muscle-specific protein 300 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 676 2.6e-68 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF14867//PF10541//PF00435//PF00837 Lantibiotic alpha//Nuclear envelope localisation domain//Spectrin repeat//Iodothyronine deiodinase GO:0055114//GO:0050830 oxidation-reduction process//defense response to Gram-positive bacterium GO:0005515//GO:0004800 protein binding//thyroxine 5'-deiodinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.37436 BP_3 367.86 6.02 3236 642939797 XP_970220.2 1685 8.6e-185 PREDICTED: uncharacterized protein LOC658765 [Tribolium castaneum] 642939796 XM_965127.2 524 0 PREDICTED: Tribolium castaneum uncharacterized LOC658765 (LOC658765), mRNA K03649 MUG, TDG TDG/mug DNA glycosylase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03649 Q13569 615 4.2e-62 G/T mismatch-specific thymine DNA glycosylase OS=Homo sapiens GN=TDG PE=1 SV=2 PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- KOG4120 G/T mismatch-specific thymine DNA glycosylase Cluster-8309.37437 BP_3 863.00 9.38 4724 91080527 XP_972163.1 746 9.6e-76 PREDICTED: alpha- and gamma-adaptin-binding protein p34 [Tribolium castaneum]>gi|270005544|gb|EFA01992.1| hypothetical protein TcasGA2_TC007613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PD74 295 7.8e-25 Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens GN=AAGAB PE=1 SV=1 PF05367//PF08408 Phage endonuclease I//DNA polymerase family B viral insert GO:0016032//GO:0006260//GO:0006308//GO:0015074 viral process//DNA replication//DNA catabolic process//DNA integration GO:0003887//GO:0008833 DNA-directed DNA polymerase activity//deoxyribonuclease IV (phage-T4-induced) activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.37438 BP_3 83.86 1.58 2844 91092022 XP_970951.1 743 1.3e-75 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q95029 629 8.8e-64 Cathepsin L OS=Drosophila melanogaster GN=Cp1 PE=2 SV=2 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37440 BP_3 531.00 79.65 613 642926167 XP_008194812.1 596 3.1e-59 PREDICTED: vinculin isoform X2 [Tribolium castaneum] -- -- -- -- -- K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 504 5.9e-50 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044 Vinculin family GO:0007155 cell adhesion GO:0051015 actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.37442 BP_3 411.00 13.40 1770 478259091 ENN79026.1 772 3.5e-79 hypothetical protein YQE_04528, partial [Dendroctonus ponderosae] -- -- -- -- -- K14295 NUP50, NPAP60 nuclear pore complex protein Nup50 http://www.genome.jp/dbget-bin/www_bget?ko:K14295 Q9UKX7 258 5.7e-21 Nuclear pore complex protein Nup50 OS=Homo sapiens GN=NUP50 PE=1 SV=2 PF00638//PF08911 RanBP1 domain//NUP50 (Nucleoporin 50 kDa) GO:0046907 intracellular transport -- -- GO:0005643 nuclear pore -- -- Cluster-8309.37443 BP_3 6464.00 285.50 1383 91086645 XP_967184.1 1227 4.7e-132 PREDICTED: lipoma HMGIC fusion partner-like 3 protein [Tribolium castaneum]>gi|270010387|gb|EFA06835.1| hypothetical protein TcasGA2_TC009778 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UP9 563 1.9e-56 Lipoma HMGIC fusion partner-like 3 protein OS=Homo sapiens GN=LHFPL3 PE=2 SV=3 PF00822//PF13903//PF02962 PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction//5-carboxymethyl-2-hydroxymuconate isomerase GO:0018874//GO:0019439//GO:0006570 benzoate metabolic process//aromatic compound catabolic process//tyrosine metabolic process GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity GO:0016021 integral component of membrane KOG4026 Uncharacterized conserved protein Cluster-8309.37444 BP_3 130.21 0.95 6929 642922445 XP_008193172.1 5130 0.0e+00 PREDICTED: uncharacterized protein LOC655273 [Tribolium castaneum] 665794170 XM_008546548.1 48 6.54984e-13 PREDICTED: Microplitis demolitor adenylate cyclase type 8 (LOC103569316), transcript variant X1, mRNA K08048 ADCY8 adenylate cyclase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08048 P40145 1172 2.3e-126 Adenylate cyclase type 8 OS=Homo sapiens GN=ADCY8 PE=1 SV=1 PF00211//PF15168//PF06327//PF07701 Adenylate and Guanylate cyclase catalytic domain//Triple QxxK/R motif-containing protein family//Domain of Unknown Function (DUF1053)//Heme NO binding associated GO:0035556//GO:0009190//GO:0006171//GO:0006144//GO:0006182//GO:0046039 intracellular signal transduction//cyclic nucleotide biosynthetic process//cAMP biosynthetic process//purine nucleobase metabolic process//cGMP biosynthetic process//GTP metabolic process GO:0016849//GO:0004016//GO:0004383 phosphorus-oxygen lyase activity//adenylate cyclase activity//guanylate cyclase activity GO:0005789//GO:0005886 endoplasmic reticulum membrane//plasma membrane -- -- Cluster-8309.37445 BP_3 1492.22 53.86 1627 478251085 ENN71561.1 1611 1.7e-176 hypothetical protein YQE_11663, partial [Dendroctonus ponderosae] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q5RAS0 1345 4.7e-147 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Pongo abelii GN=ACADS PE=2 SV=1 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.37446 BP_3 840.32 3.65 11402 642934317 XP_008198598.1 2239 1.8e-248 PREDICTED: integrin alpha-PS2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 1688 5.6e-186 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF15686//PF05375 Lysine-rich CEACAM1 co-isolated protein family//Pacifastin inhibitor (LCMII) GO:0045766//GO:0043123//GO:0043066 positive regulation of angiogenesis//positive regulation of I-kappaB kinase/NF-kappaB signaling//negative regulation of apoptotic process GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.37449 BP_3 72.36 0.45 8029 642911937 XP_008199029.1 3528 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 585 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1858 7.7e-206 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF00465//PF01412//PF13606//PF07043//PF08397//PF00885//PF03114//PF14604//PF00023//PF00018 Iron-containing alcohol dehydrogenase//Putative GTPase activating protein for Arf//Ankyrin repeat//Protein of unknown function (DUF1328)//IRSp53/MIM homology domain//6,7-dimethyl-8-ribityllumazine synthase//BAR domain//Variant SH3 domain//Ankyrin repeat//SH3 domain GO:0009231//GO:0055114//GO:0007009 riboflavin biosynthetic process//oxidation-reduction process//plasma membrane organization GO:0016491//GO:0005515//GO:0005096//GO:0046872 oxidoreductase activity//protein binding//GTPase activator activity//metal ion binding GO:0005886//GO:0005737//GO:0009349 plasma membrane//cytoplasm//riboflavin synthase complex KOG3857 Alcohol dehydrogenase, class IV Cluster-8309.37450 BP_3 277.76 9.65 1679 189238828 XP_969342.2 1477 5.9e-161 PREDICTED: peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 isoform X1 [Tribolium castaneum]>gi|270009957|gb|EFA06405.1| hypothetical protein TcasGA2_TC009284 [Tribolium castaneum] -- -- -- -- -- K18200 PAL peptidylamidoglycolate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K18200 Q9W1L5 1013 1.5e-108 Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 OS=Drosophila melanogaster GN=Pal2 PE=1 SV=2 PF01436//PF01983 NHL repeat//Guanylyl transferase CofC like GO:0055114//GO:0006518 oxidation-reduction process//peptide metabolic process GO:0004504//GO:0005507//GO:0016779//GO:0005515 peptidylglycine monooxygenase activity//copper ion binding//nucleotidyltransferase activity//protein binding GO:0016020 membrane KOG3567 Peptidylglycine alpha-amidating monooxygenase Cluster-8309.37451 BP_3 3250.41 26.03 6311 546681613 ERL91677.1 2243 3.3e-249 hypothetical protein D910_09004 [Dendroctonus ponderosae] 241591921 XM_002403988.1 180 2.49479e-86 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19029 PFKFB2 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19029 Q91309 1435 6.8e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF01591//PF00973//PF05470//PF06414 6-phosphofructo-2-kinase//Paramyxovirus nucleocapsid protein//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Zeta toxin GO:0006013//GO:0006000//GO:0006413//GO:0006446 mannose metabolic process//fructose metabolic process//translational initiation//regulation of translational initiation GO:0031369//GO:0016301//GO:0005198//GO:0003873//GO:0005524//GO:0003743 translation initiation factor binding//kinase activity//structural molecule activity//6-phosphofructo-2-kinase activity//ATP binding//translation initiation factor activity GO:0019013//GO:0005852//GO:0005840 viral nucleocapsid//eukaryotic translation initiation factor 3 complex//ribosome KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.37454 BP_3 1587.46 11.73 6812 795370015 XP_011748985.1 261 2.4e-19 PREDICTED: neurofilament heavy polypeptide isoform X4 [Macaca nemestrina]>gi|795370020|ref|XP_011748986.1| PREDICTED: neurofilament heavy polypeptide isoform X5 [Macaca nemestrina]>gi|795370026|ref|XP_011748987.1| PREDICTED: neurofilament heavy polypeptide isoform X6 [Macaca nemestrina] -- -- -- -- -- -- -- -- -- P12036 226 1.1e-16 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.37455 BP_3 212.15 8.37 1514 642914509 XP_008201706.1 624 4.3e-62 PREDICTED: transcriptional enhancer factor TEF-1 isoform X1 [Tribolium castaneum] 642914508 XM_008203484.1 168 2.75736e-80 PREDICTED: Tribolium castaneum scalloped (LOC658922), transcript variant X1, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P30052 502 2.5e-49 Protein scalloped OS=Drosophila melanogaster GN=sd PE=1 SV=1 PF00424//PF01285 REV protein (anti-repression trans-activator protein)//TEA/ATTS domain family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634//GO:0042025 transcription factor complex//nucleus//host cell nucleus KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.37456 BP_3 154.15 2.33 3484 642914509 XP_008201706.1 1580 1.4e-172 PREDICTED: transcriptional enhancer factor TEF-1 isoform X1 [Tribolium castaneum] 642914508 XM_008203484.1 507 0 PREDICTED: Tribolium castaneum scalloped (LOC658922), transcript variant X1, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P28347 1170 2.0e-126 Transcriptional enhancer factor TEF-1 OS=Homo sapiens GN=TEAD1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.37457 BP_3 229.99 139.50 368 350646286 CCD59012.1 148 1.6e-07 saposin containing protein [Schistosoma mansoni] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37458 BP_3 645.78 6.96 4767 642933145 XP_008197275.1 2063 1.9e-228 PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum]>gi|642933147|ref|XP_008197277.1| PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum] 642933146 XM_008199055.1 280 4.84044e-142 PREDICTED: Tribolium castaneum extracellular serine/threonine protein kinase FAM20C (LOC662687), transcript variant X2, mRNA -- -- -- -- A4VCL2 1488 3.6e-163 Extracellular serine/threonine protein CG31145 OS=Drosophila melanogaster GN=CG31145 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3829 Uncharacterized conserved protein Cluster-8309.37459 BP_3 3343.25 43.69 3980 546676946 ERL87870.1 631 1.8e-62 hypothetical protein D910_05258 [Dendroctonus ponderosae] 817210375 XM_012425850.1 99 1.67192e-41 PREDICTED: Orussus abietinus gamma-aminobutyric acid receptor-associated protein (LOC105700198), mRNA K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 Q9GJW7 574 2.9e-57 Gamma-aminobutyric acid receptor-associated protein OS=Bos taurus GN=GABARAP PE=3 SV=2 PF04110//PF00961 Ubiquitin-like autophagy protein Apg12//LAGLIDADG endonuclease GO:0000045 autophagosome assembly GO:0004519 endonuclease activity GO:0005737 cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-8309.37460 BP_3 1362.81 101.48 939 642915391 XP_008190597.1 403 1.1e-36 PREDICTED: cytochrome c oxidase subunit 6B2 isoform X1 [Tribolium castaneum] 642915392 XM_969527.2 84 8.36861e-34 PREDICTED: Tribolium castaneum cytochrome c oxidase subunit 6B2 (LOC663486), transcript variant X2, mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 P14854 264 6.1e-22 Cytochrome c oxidase subunit 6B1 OS=Homo sapiens GN=COX6B1 PE=1 SV=2 PF02297 Cytochrome oxidase c subunit VIb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005739 respiratory chain complex IV//mitochondrion KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.37461 BP_3 692.80 5.64 6211 478253975 ENN74267.1 3030 0.0e+00 hypothetical protein YQE_09239, partial [Dendroctonus ponderosae] 642910904 XM_008195237.1 248 3.88393e-124 PREDICTED: Tribolium castaneum trithorax group protein osa (LOC100141527), mRNA K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 1475 1.5e-161 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 PF15750//PF01388//PF12031//PF00375//PF01435 Ubiquitin-binding zinc-finger//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518)//Sodium:dicarboxylate symporter family//Peptidase family M48 GO:0006338//GO:0006820//GO:0006835//GO:0006812//GO:0006508 chromatin remodeling//anion transport//dicarboxylic acid transport//cation transport//proteolysis GO:0043130//GO:0004222//GO:0003677//GO:0017153 ubiquitin binding//metalloendopeptidase activity//DNA binding//sodium:dicarboxylate symporter activity GO:0090544//GO:0016020 BAF-type complex//membrane KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-8309.37462 BP_3 583.61 4.89 6041 478253975 ENN74267.1 3030 0.0e+00 hypothetical protein YQE_09239, partial [Dendroctonus ponderosae] 642910904 XM_008195237.1 326 1.64887e-167 PREDICTED: Tribolium castaneum trithorax group protein osa (LOC100141527), mRNA K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 1475 1.5e-161 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 PF01388//PF00375//PF12031//PF15750//PF01435 ARID/BRIGHT DNA binding domain//Sodium:dicarboxylate symporter family//Domain of unknown function (DUF3518)//Ubiquitin-binding zinc-finger//Peptidase family M48 GO:0006338//GO:0006820//GO:0006812//GO:0006835//GO:0006508 chromatin remodeling//anion transport//cation transport//dicarboxylic acid transport//proteolysis GO:0004222//GO:0043130//GO:0003677//GO:0017153 metalloendopeptidase activity//ubiquitin binding//DNA binding//sodium:dicarboxylate symporter activity GO:0090544//GO:0016020 BAF-type complex//membrane KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-8309.37463 BP_3 1743.05 28.10 3282 189241616 XP_966968.2 900 9.3e-94 PREDICTED: cyclic AMP response element-binding protein A-like isoform X3 [Tribolium castaneum] 195590478 XM_002084937.1 97 1.78e-40 Drosophila simulans GD14552 (Dsim\GD14552), mRNA K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 P29747 388 8.9e-36 Cyclic AMP response element-binding protein A OS=Drosophila melanogaster GN=CrebA PE=1 SV=2 PF04111//PF01544//PF00170//PF06005//PF03131//PF07926//PF07716//PF02183 Autophagy protein Apg6//CorA-like Mg2+ transporter protein//bZIP transcription factor//Protein of unknown function (DUF904)//bZIP Maf transcription factor//TPR/MLP1/MLP2-like protein//Basic region leucine zipper//Homeobox associated leucine zipper GO:0000917//GO:0043093//GO:0006606//GO:0006355//GO:0006914//GO:0030001//GO:0055085 barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//regulation of transcription, DNA-templated//autophagy//metal ion transport//transmembrane transport GO:0003700//GO:0043565//GO:0046873//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//metal ion transmembrane transporter activity//DNA binding GO:0005737//GO:0016020//GO:0005667//GO:0005634 cytoplasm//membrane//transcription factor complex//nucleus KOG0709 CREB/ATF family transcription factor Cluster-8309.37464 BP_3 8.97 0.58 1034 478259808 ENN79636.1 194 2.1e-12 hypothetical protein YQE_03925, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- -- -- Cluster-8309.37465 BP_3 8.45 0.54 1040 668456957 KFB45030.1 231 1.1e-16 AGAP005662-PA-like protein [Anopheles sinensis] -- -- -- -- -- K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 A5A6I0 219 1.1e-16 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Pan troglodytes GN=ACADM PE=2 SV=1 PF02770 Acyl-CoA dehydrogenase, middle domain GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0003995 acyl-CoA dehydrogenase activity -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.37466 BP_3 3345.11 54.23 3265 642928069 XP_968571.3 1731 4.0e-190 PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|642928071|ref|XP_008200143.1| PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|270010871|gb|EFA07319.1| hypothetical protein TcasGA2_TC015912 [Tribolium castaneum] -- -- -- -- -- K01581 E4.1.1.17, ODC1, speC, speF ornithine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01581 P27117 1041 1.7e-111 Ornithine decarboxylase OS=Bos taurus GN=ODC1 PE=2 SV=1 PF00278//PF02784 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Pyridoxal-dependent decarboxylase, pyridoxal binding domain GO:0006596 polyamine biosynthetic process GO:0003824 catalytic activity -- -- KOG0622 Ornithine decarboxylase Cluster-8309.37467 BP_3 543.78 5.05 5484 91078042 XP_966587.1 1233 3.8e-132 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCI3 792 2.1e-82 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37468 BP_3 63.63 2.20 1683 546683249 ERL93081.1 549 2.4e-53 hypothetical protein D910_10383 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q71RG4 208 3.4e-15 Transmembrane and ubiquitin-like domain-containing protein 2 OS=Homo sapiens GN=TMUB2 PE=1 SV=2 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37473 BP_3 237.27 1.54 7703 91084687 XP_968830.1 2064 2.3e-228 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] 831284033 XM_012817767.1 98 1.16844e-40 PREDICTED: Clupea harengus myotubularin-related protein 3-like (LOC105891591), mRNA K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q13615 1307 5.7e-142 Myotubularin-related protein 3 OS=Homo sapiens GN=MTMR3 PE=1 SV=3 PF00102//PF00400//PF07646//PF00782//PF01363 Protein-tyrosine phosphatase//WD domain, G-beta repeat//Kelch motif//Dual specificity phosphatase, catalytic domain//FYVE zinc finger GO:0006570//GO:0006470//GO:0035335 tyrosine metabolic process//protein dephosphorylation//peptidyl-tyrosine dephosphorylation GO:0008138//GO:0005515//GO:0004725//GO:0046872 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//metal ion binding -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.37474 BP_3 756.16 6.81 5646 642936679 XP_008198534.1 580 2.0e-56 PREDICTED: protein rhomboid isoform X1 [Tribolium castaneum] 751781411 XM_011201569.1 47 1.91815e-12 PREDICTED: Bactrocera dorsalis cAMP-responsive element-binding protein-like 2 (LOC105223754), mRNA -- -- -- -- A4IGK3 291 2.7e-24 cAMP-responsive element-binding protein-like 2 OS=Xenopus tropicalis GN=crebl2 PE=3 SV=1 PF05832//PF01694//PF00170//PF07716 Eukaryotic protein of unknown function (DUF846)//Rhomboid family//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0004252//GO:0003700 sequence-specific DNA binding//serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG2289 Rhomboid family proteins Cluster-8309.37475 BP_3 13.00 16.84 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37476 BP_3 60.75 0.36 8360 189236706 XP_974173.2 1532 1.2e-166 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 349 3.74272e-180 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 652 5.6e-66 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.37477 BP_3 2425.14 26.02 4784 642929898 XP_975679.2 1290 8.1e-139 PREDICTED: protein CASC3 [Tribolium castaneum] -- -- -- -- -- K07951 ARL6, BBS3 ADP-ribosylation factor-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K07951 Q5M9P8 512 5.5e-50 ADP-ribosylation factor-like protein 6 OS=Danio rerio GN=arl6 PE=2 SV=1 PF08477//PF04995//PF01926//PF00025//PF02421//PF00503//PF00071//PF04670//PF01580 Ras of Complex, Roc, domain of DAPkinase//Heme exporter protein D (CcmD)//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ferrous iron transport protein B//G-protein alpha subunit//Ras family//Gtr1/RagA G protein conserved region//FtsK/SpoIIIE family GO:0007186//GO:0017004//GO:0015684//GO:0007165//GO:0007264//GO:0015886 G-protein coupled receptor signaling pathway//cytochrome complex assembly//ferrous iron transport//signal transduction//small GTPase mediated signal transduction//heme transport GO:0000166//GO:0019001//GO:0005524//GO:0031683//GO:0003924//GO:0005525//GO:0004871//GO:0015093//GO:0003677 nucleotide binding//guanyl nucleotide binding//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//signal transducer activity//ferrous iron transmembrane transporter activity//DNA binding GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.37478 BP_3 12895.94 253.68 2742 765527267 AJS10722.1 1235 1.1e-132 14-3-3 zeta [Tenebrio molitor] 642911747 XM_008202503.1 574 0 PREDICTED: Tribolium castaneum 14-3-3 protein zeta (LOC660150), mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 1149 4.3e-124 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 PF17098 Pre-mRNA-splicing regulator WTAP GO:0048024 regulation of mRNA splicing, via spliceosome -- -- GO:0005634 nucleus -- -- Cluster-8309.37480 BP_3 249.93 6.28 2211 332373744 AEE62013.1 291 2.6e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5EF78 135 1.3e-06 Icarapin OS=Apis mellifera carnica PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37481 BP_3 726.83 14.11 2774 91081545 XP_974976.1 1293 2.1e-139 PREDICTED: calumenin [Tribolium castaneum]>gi|270006175|gb|EFA02623.1| hypothetical protein TcasGA2_TC008343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDD8 880 6.7e-93 Calumenin OS=Pongo abelii GN=CALU PE=2 SV=1 PF13202//PF08707//PF00036//PF10591//PF13833//PF13405//PF13499 EF hand//Primase C terminal 2 (PriCT-2)//EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.37482 BP_3 9801.85 158.90 3265 91077504 XP_966852.1 2795 0.0e+00 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P26779 409 3.3e-38 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF05184//PF02627 Saposin-like type B, region 1//Carboxymuconolactone decarboxylase family GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process GO:0051920 peroxiredoxin activity -- -- -- -- Cluster-8309.37483 BP_3 200.28 3.22 3292 270001532 EEZ97979.1 2481 4.4e-277 hypothetical protein TcasGA2_TC000374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61627 319 9.0e-28 Glutamate receptor ionotropic, delta-1 OS=Mus musculus GN=Grid1 PE=1 SV=2 PF07826//PF10613//PF00060 IMP cyclohydrolase-like protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006164//GO:0007268//GO:0006144//GO:0006188//GO:0007165//GO:0006811//GO:0006807 purine nucleotide biosynthetic process//synaptic transmission//purine nucleobase metabolic process//IMP biosynthetic process//signal transduction//ion transport//nitrogen compound metabolic process GO:0005234//GO:0004970//GO:0003937 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//IMP cyclohydrolase activity GO:0016020//GO:0042720 membrane//mitochondrial inner membrane peptidase complex -- -- Cluster-8309.37484 BP_3 129.97 0.96 6825 642921666 XP_008192914.1 2161 1.2e-239 PREDICTED: polycomb protein Asx isoform X1 [Tribolium castaneum]>gi|270007351|gb|EFA03799.1| hypothetical protein TcasGA2_TC013912 [Tribolium castaneum] -- -- -- -- -- K11471 ASXL additional sex combs-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11471 Q9V727 566 4.3e-56 Polycomb protein Asx OS=Drosophila melanogaster GN=Asx PE=1 SV=1 PF12515//PF13922 Ca2+-ATPase N terminal autoinhibitory domain//PHD domain of transcriptional enhancer, Asx -- -- GO:0003677//GO:0005516 DNA binding//calmodulin binding -- -- -- -- Cluster-8309.37485 BP_3 260.37 9.75 1579 91093477 XP_968017.1 1493 7.7e-163 PREDICTED: U5 small nuclear ribonucleoprotein 40 kDa protein [Tribolium castaneum]>gi|270012667|gb|EFA09115.1| hypothetical protein TcasGA2_TC015975 [Tribolium castaneum] -- -- -- -- -- K12857 SNRNP40, PRP8BP Prp8 binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K12857 Q96DI7 1150 1.9e-124 U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens GN=SNRNP40 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0265 U5 snRNP-specific protein-like factor and related proteins Cluster-8309.37487 BP_3 196.63 4.75 2289 270016491 EFA12937.1 319 1.5e-26 hypothetical protein TcasGA2_TC010484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43422 178 1.4e-11 52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens GN=PRKRIR PE=1 SV=2 PF03854 P-11 zinc finger -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.37489 BP_3 34.28 0.31 5640 642934848 XP_008197836.1 1638 4.2e-179 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.82509e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA -- -- -- -- Q5JR59 239 2.9e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3749 BP_3 1.00 4.05 270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37490 BP_3 288.00 37.69 660 805809799 XP_012146944.1 608 1.3e-60 PREDICTED: uncharacterized protein LOC100882817 isoform X1 [Megachile rotundata] -- -- -- -- -- -- -- -- -- O16264 476 1.1e-46 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.37491 BP_3 11.19 0.38 1703 546672637 ERL84433.1 1024 2.0e-108 hypothetical protein D910_01865, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5YCC5 398 3.2e-37 Transmembrane channel-like protein 7 OS=Gallus gallus GN=Tmc7 PE=2 SV=1 PF06305//PF07810 Protein of unknown function (DUF1049)//TMC domain -- -- -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.37495 BP_3 42.89 0.51 4324 270001798 EEZ98245.1 3596 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 469 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q10057 146 1.4e-07 Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC1F5.02 PE=3 SV=1 PF00085//PF02382//PF02020//PF01791 Thioredoxin//RTX N-terminal domain//eIF4-gamma/eIF5/eIF2-epsilon//DeoC/LacD family aldolase GO:0009405//GO:0045454 pathogenesis//cell redox homeostasis GO:0005509//GO:0005515//GO:0016829 calcium ion binding//protein binding//lyase activity GO:0005576 extracellular region KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.37496 BP_3 66.77 0.32 10324 642916116 XP_008190891.1 1596 5.8e-174 PREDICTED: nuclear pore complex protein Nup153 [Tribolium castaneum] 642916113 XM_008192668.1 107 1.55688e-45 PREDICTED: Tribolium castaneum WW domain-containing adapter protein with coiled-coil (LOC660923), mRNA -- -- -- -- P49790 578 2.6e-57 Nuclear pore complex protein Nup153 OS=Homo sapiens GN=NUP153 PE=1 SV=2 PF03172//PF00641//PF03083 Sp100 domain//Zn-finger in Ran binding protein and others//Sugar efflux transporter for intercellular exchange -- -- GO:0008270 zinc ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.37497 BP_3 1635.00 62.73 1548 646705124 KDR13003.1 1380 9.6e-150 Serine-threonine kinase receptor-associated protein [Zootermopsis nevadensis] -- -- -- -- -- K13137 STRAP, UNRIP serine-threonine kinase receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K13137 Q5ZL33 1065 1.3e-114 Serine-threonine kinase receptor-associated protein OS=Gallus gallus GN=STRAP PE=2 SV=2 PF06433//PF00400 Methylamine dehydrogenase heavy chain (MADH)//WD domain, G-beta repeat GO:0015947//GO:0055114 methane metabolic process//oxidation-reduction process GO:0030058//GO:0005515 amine dehydrogenase activity//protein binding GO:0042597 periplasmic space KOG0278 Serine/threonine kinase receptor-associated protein Cluster-8309.37498 BP_3 101.26 2.21 2499 642926721 XP_008194985.1 1684 8.7e-185 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 564 2.7e-56 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.37499 BP_3 60.44 0.83 3805 642932100 XP_008196854.1 1535 2.5e-167 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.25272e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.9e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF07525//PF00622//PF01213 SOCS box//SPRY domain//Adenylate cyclase associated (CAP) N terminal GO:0007010//GO:0035556 cytoskeleton organization//intracellular signal transduction GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.375 BP_3 8.00 0.34 1439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37501 BP_3 84.28 1.64 2773 546674950 ERL86223.1 2101 4.3e-233 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 1.05084e-111 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1601 1.7e-176 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF03949//PF00390 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0006090//GO:0015976//GO:0006099//GO:0055114//GO:0006108 pyruvate metabolic process//carbon utilization//tricarboxylic acid cycle//oxidation-reduction process//malate metabolic process GO:0004471//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.37502 BP_3 451.31 3.69 6193 345483040 XP_003424731.1 2293 5.2e-255 PREDICTED: poly [ADP-ribose] polymerase [Nasonia vitripennis] 505789579 XM_004605427.1 81 2.64723e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 1735 1.1e-191 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00646//PF08063//PF00644//PF02877//PF00645 F-box domain//PADR1 (NUC008) domain//Poly(ADP-ribose) polymerase catalytic domain//Poly(ADP-ribose) polymerase, regulatory domain//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0006471 protein ADP-ribosylation GO:0003950//GO:0005515//GO:0008270//GO:0003677 NAD+ ADP-ribosyltransferase activity//protein binding//zinc ion binding//DNA binding GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.37503 BP_3 216.04 2.20 5033 752875790 XP_011255262.1 426 1.3e-38 PREDICTED: ER lumen protein-retaining receptor [Camponotus floridanus]>gi|307181434|gb|EFN69029.1| ER lumen protein retaining receptor [Camponotus floridanus] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 Q66JF2 429 2.4e-40 ER lumen protein-retaining receptor 3 OS=Xenopus tropicalis GN=kdelr3 PE=2 SV=1 PF05297//PF00810 Herpesvirus latent membrane protein 1 (LMP1)//ER lumen protein retaining receptor GO:0006621//GO:0019087 protein retention in ER lumen//transformation of host cell by virus GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG3106 ER lumen protein retaining receptor Cluster-8309.37504 BP_3 20.19 0.96 1310 642936649 XP_008198523.1 747 2.0e-76 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Tribolium castaneum]>gi|270013058|gb|EFA09506.1| hypothetical protein TcasGA2_TC011607 [Tribolium castaneum] -- -- -- -- -- K09458 fabF 3-oxoacyl- http://www.genome.jp/dbget-bin/www_bget?ko:K09458 Q0VCA7 578 3.3e-58 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Bos taurus GN=OXSM PE=2 SV=1 PF00108 Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016740//GO:0016747 transferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.37506 BP_3 77.62 2.23 1971 820805536 AKG92759.1 682 1.1e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 3.01602e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 5.2e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF01586//PF00010 Myogenic Basic domain//Helix-loop-helix DNA-binding domain GO:0007517//GO:0006355 muscle organ development//regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.37508 BP_3 177.79 6.05 1708 91090210 XP_967762.1 1293 1.3e-139 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P09875 506 9.7e-50 UDP-glucuronosyltransferase 2B1 OS=Rattus norvegicus GN=Ugt2b1 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758//GO:0016757 transferase activity, transferring hexosyl groups//transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.37509 BP_3 1976.78 46.18 2355 189236600 XP_001816436.1 1585 2.5e-173 PREDICTED: sensory neuron membrane protein 1 [Tribolium castaneum]>gi|332321724|sp|D2A0H5.1|SNMP1_TRICA RecName: Full=Sensory neuron membrane protein 1 [Tribolium castaneum]>gi|270006451|gb|EFA02899.1| sensory neuron membrane protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2A0H5 1585 1.0e-174 Sensory neuron membrane protein 1 OS=Tribolium castaneum GN=SNMP01 PE=3 SV=1 PF01130 CD36 family GO:0007155//GO:0044699 cell adhesion//single-organism process -- -- GO:0016020 membrane -- -- Cluster-8309.37511 BP_3 58.84 1.12 2818 91078972 XP_974414.1 1107 7.9e-118 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 605 5.3e-61 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868 Transglutaminase family GO:0018149 peptide cross-linking GO:0046872//GO:0003810 metal ion binding//protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.37512 BP_3 1144.49 26.07 2408 642921190 XP_008192754.1 999 2.3e-105 PREDICTED: reticulon-1-A-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 482 8.3e-47 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF00834 Ribulose-phosphate 3 epimerase family GO:0005975 carbohydrate metabolic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives -- -- KOG1792 Reticulon Cluster-8309.37513 BP_3 134.48 2.02 3499 642921186 XP_008192751.1 809 3.5e-83 PREDICTED: reticulon-1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 460 4.3e-44 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF00834//PF01442 Ribulose-phosphate 3 epimerase family//Apolipoprotein A1/A4/E domain GO:0005975//GO:0006869//GO:0042157 carbohydrate metabolic process//lipid transport//lipoprotein metabolic process GO:0016857//GO:0008289 racemase and epimerase activity, acting on carbohydrates and derivatives//lipid binding GO:0005576 extracellular region KOG1792 Reticulon Cluster-8309.37515 BP_3 60.24 2.23 1595 573896974 XP_006636225.1 161 2.2e-08 PREDICTED: tissue factor pathway inhibitor 2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- O54819 145 6.5e-08 Tissue factor pathway inhibitor OS=Mus musculus GN=Tfpi PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.37517 BP_3 1564.99 7.29 10641 270001100 EEZ97547.1 2545 5.4e-284 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] 170032990 XM_001844311.1 225 4.07003e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 9.8e-217 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF00595//PF14304//PF13855//PF00412//PF13180//PF10468//PF00560//PF01378 PDZ domain (Also known as DHR or GLGF)//Transcription termination and cleavage factor C-terminal//Leucine rich repeat//LIM domain//PDZ domain//Carboxypeptidase inhibitor I68//Leucine Rich Repeat//B domain GO:0031124//GO:0007596//GO:0010951 mRNA 3'-end processing//blood coagulation//negative regulation of endopeptidase activity GO:0008191//GO:0008270//GO:0005515 metalloendopeptidase inhibitor activity//zinc ion binding//protein binding GO:0005618 cell wall KOG0619 FOG: Leucine rich repeat Cluster-8309.37520 BP_3 651.70 16.61 2183 189235991 XP_972419.2 922 1.7e-96 PREDICTED: dnaJ homolog subfamily B member 14 [Tribolium castaneum] -- -- -- -- -- K09518 DNAJB12 DnaJ homolog subfamily B member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09518 Q9NXW2 372 4.3e-34 DnaJ homolog subfamily B member 12 OS=Homo sapiens GN=DNAJB12 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.37521 BP_3 230.15 2.96 4045 642927864 XP_008195430.1 2314 1.2e-257 PREDICTED: inhibitor of Bruton tyrosine kinase [Tribolium castaneum]>gi|270010253|gb|EFA06701.1| hypothetical protein TcasGA2_TC009632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPR6 1063 5.9e-114 Inhibitor of Bruton tyrosine kinase OS=Mus musculus GN=Ibtk PE=1 SV=3 PF00023//PF00651//PF13606//PF05224 Ankyrin repeat//BTB/POZ domain//Ankyrin repeat//NDT80 / PhoG like DNA-binding family -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0783 Uncharacterized conserved protein, contains ankyrin and BTB/POZ domains Cluster-8309.37522 BP_3 5889.15 24.66 11802 642917812 XP_008191295.1 7401 0.0e+00 PREDICTED: ankyrin-3-like isoform X3 [Tribolium castaneum] 801371747 XM_012207187.1 386 0 PREDICTED: Atta cephalotes uncharacterized LOC105625877 (LOC105625877), mRNA K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 4153 0.0e+00 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF04277//PF13606//PF00531//PF01442//PF00023 Oxaloacetate decarboxylase, gamma chain//Ankyrin repeat//Death domain//Apolipoprotein A1/A4/E domain//Ankyrin repeat GO:0071436//GO:0006090//GO:0006814//GO:0042157//GO:0006525//GO:0007165//GO:0006560//GO:0006869 sodium ion export//pyruvate metabolic process//sodium ion transport//lipoprotein metabolic process//arginine metabolic process//signal transduction//proline metabolic process//lipid transport GO:0015081//GO:0008289//GO:0005515//GO:0008948 sodium ion transmembrane transporter activity//lipid binding//protein binding//oxaloacetate decarboxylase activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.37524 BP_3 153.00 10.27 1010 557876145 AHA39267.1 342 1.4e-29 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- Q27018 152 6.4e-09 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.37525 BP_3 792.00 28.44 1634 546675887 ERL86992.1 2177 3.9e-242 hypothetical protein D910_04395 [Dendroctonus ponderosae] 827557709 XM_004930962.2 230 1.02038e-114 PREDICTED: Bombyx mori probable 26S proteasome non-ATPase regulatory subunit 3 (LOC101746211), mRNA K03033 PSMD3, RPN3 26S proteasome regulatory subunit N3 http://www.genome.jp/dbget-bin/www_bget?ko:K03033 O61470 1775 6.6e-197 Probable 26S proteasome non-ATPase regulatory subunit 3 OS=Anopheles gambiae GN=Dox-A2 PE=3 SV=2 PF08375//PF07503//PF01399 Proteasome regulatory subunit C-terminal//HypF finger//PCI domain GO:0042176 regulation of protein catabolic process GO:0008270//GO:0030234//GO:0005515 zinc ion binding//enzyme regulator activity//protein binding GO:0000502 proteasome complex KOG2581 26S proteasome regulatory complex, subunit RPN3/PSMD3 Cluster-8309.37526 BP_3 1322.48 22.18 3166 91084647 XP_966816.1 2399 1.4e-267 PREDICTED: carboxypeptidase D [Tribolium castaneum] -- -- -- -- -- K07752 CPD carboxypeptidase D http://www.genome.jp/dbget-bin/www_bget?ko:K07752 P42787 1299 2.0e-141 Carboxypeptidase D OS=Drosophila melanogaster GN=svr PE=1 SV=2 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0004181//GO:0008270 metallocarboxypeptidase activity//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.37528 BP_3 360.67 6.01 3186 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37529 BP_3 2562.50 62.40 2271 91077138 XP_971446.1 1715 2.0e-188 PREDICTED: dnaJ homolog subfamily A member 1 [Tribolium castaneum]>gi|270001716|gb|EEZ98163.1| hypothetical protein TcasGA2_TC000590 [Tribolium castaneum] 817197334 XM_012418859.1 190 2.45621e-92 PREDICTED: Orussus abietinus dnaJ homolog subfamily A member 1 (LOC105696421), transcript variant X2, mRNA K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 Q5E954 1351 1.3e-147 DnaJ homolog subfamily A member 1 OS=Bos taurus GN=DNAJA1 PE=2 SV=2 PF16685//PF01155//PF00684 zinc RING finger of MSL2//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//DnaJ central domain GO:0006260//GO:0009408//GO:0006457//GO:0006464 DNA replication//response to heat//protein folding//cellular protein modification process GO:0046872//GO:0051082//GO:0016151//GO:0061630//GO:0031072//GO:0005524 metal ion binding//unfolded protein binding//nickel cation binding//ubiquitin protein ligase activity//heat shock protein binding//ATP binding GO:0005737 cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.37530 BP_3 744.96 4.30 8637 91079160 XP_967064.1 4270 0.0e+00 PREDICTED: E3 SUMO-protein ligase RanBP2 [Tribolium castaneum]>gi|270003619|gb|EFA00067.1| hypothetical protein TcasGA2_TC002881 [Tribolium castaneum] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 371 2.2e-33 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF06810//PF04513//PF09177//PF00641//PF00638 Phage minor structural protein GP20//Baculovirus polyhedron envelope protein, PEP, C terminus//Syntaxin 6, N-terminal//Zn-finger in Ran binding protein and others//RanBP1 domain GO:0048193//GO:0046907 Golgi vesicle transport//intracellular transport GO:0008270//GO:0005198 zinc ion binding//structural molecule activity GO:0019028//GO:0016020//GO:0019031 viral capsid//membrane//viral envelope KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.37531 BP_3 2419.66 12.85 9365 91079160 XP_967064.1 5066 0.0e+00 PREDICTED: E3 SUMO-protein ligase RanBP2 [Tribolium castaneum]>gi|270003619|gb|EFA00067.1| hypothetical protein TcasGA2_TC002881 [Tribolium castaneum] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 495 1.0e-47 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF00638//PF13181//PF06810//PF13371//PF00641//PF00515//PF13414//PF13176 RanBP1 domain//Tetratricopeptide repeat//Phage minor structural protein GP20//Tetratricopeptide repeat//Zn-finger in Ran binding protein and others//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0046907 intracellular transport GO:0005198//GO:0005515//GO:0008270 structural molecule activity//protein binding//zinc ion binding -- -- KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.37532 BP_3 407.76 2.61 7828 189241221 XP_001812199.1 1072 2.5e-113 PREDICTED: carboxypeptidase D-like [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 749 2.9e-77 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF06008//PF00246//PF04977//PF05531//PF16326//PF04952//PF07544//PF00018//PF01166 Laminin Domain I//Zinc carboxypeptidase//Septum formation initiator//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//Succinylglutamate desuccinylase / Aspartoacylase family//RNA polymerase II transcription mediator complex subunit 9//SH3 domain//TSC-22/dip/bun family GO:0008152//GO:0006508//GO:0030155//GO:0030334//GO:0007165//GO:0006357//GO:0006355//GO:0045995//GO:0007049 metabolic process//proteolysis//regulation of cell adhesion//regulation of cell migration//signal transduction//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//regulation of embryonic development//cell cycle GO:0001104//GO:0003677//GO:0016788//GO:0005515//GO:0005102//GO:0008270//GO:0004181//GO:0003700 RNA polymerase II transcription cofactor activity//DNA binding//hydrolase activity, acting on ester bonds//protein binding//receptor binding//zinc ion binding//metallocarboxypeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0016592//GO:0005667//GO:0019028 mediator complex//transcription factor complex//viral capsid KOG2649 Zinc carboxypeptidase Cluster-8309.37534 BP_3 55.24 0.42 6692 546674960 ERL86230.1 1407 3.1e-152 hypothetical protein D910_03641 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A0FGR8 565 5.5e-56 Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2 PE=1 SV=1 PF17047//PF00168 Synaptotagmin-like mitochondrial-lipid-binding domain//C2 domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.37536 BP_3 655.48 3.66 8920 642918470 XP_008191489.1 1571 3.9e-171 PREDICTED: protein NDRG3 isoform X2 [Tribolium castaneum] 462464055 APGK01005064.1 69 1.789e-24 Dendroctonus ponderosae Seq01005066, whole genome shotgun sequence -- -- -- -- Q5RA95 642 8.6e-65 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.37537 BP_3 25.85 0.73 2010 642917810 XP_008191294.1 2849 0.0e+00 PREDICTED: ankyrin-3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q01484 2167 2.8e-242 Ankyrin-2 OS=Homo sapiens GN=ANK2 PE=1 SV=4 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.37538 BP_3 194.98 11.21 1130 642913599 XP_008201080.1 343 1.2e-29 PREDICTED: extensin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37542 BP_3 2231.26 31.76 3678 91078104 XP_972867.1 1786 1.9e-196 PREDICTED: spondin-2 isoform X1 [Tribolium castaneum] 642914951 XM_967774.3 433 0 PREDICTED: Tribolium castaneum spondin-2 (LOC661624), transcript variant X1, mRNA -- -- -- -- Q9WV75 510 7.2e-50 Spondin-2 OS=Rattus norvegicus GN=Spon2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.37543 BP_3 279.26 5.94 2558 642934689 XP_972767.2 3035 0.0e+00 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 D3ZGS3 1477 3.7e-162 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Rattus norvegicus GN=Ocrl PE=1 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.37545 BP_3 124.72 1.10 5779 91092690 XP_971771.1 1827 5.3e-201 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 6.35138e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K04454 MEF2C MADS-box transcription enhancer factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K04454 P40791 941 1.2e-99 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.37550 BP_3 446.72 17.02 1557 211939884 ACJ13424.1 872 7.8e-91 serpin [Sphenophorus levis] -- -- -- -- -- -- -- -- -- P80034 579 3.0e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37551 BP_3 691.20 18.31 2111 642940096 XP_008192965.1 1240 2.2e-133 PREDICTED: paxillin isoform X6 [Tribolium castaneum]>gi|270016014|gb|EFA12462.1| hypothetical protein TcasGA2_TC010609 [Tribolium castaneum] 665811408 XM_008555945.1 200 6.2958e-98 PREDICTED: Microplitis demolitor leupaxin-like (LOC103575940), mRNA K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 P49024 831 2.5e-87 Paxillin OS=Gallus gallus GN=PXN PE=1 SV=1 PF01258//PF00412 Prokaryotic dksA/traR C4-type zinc finger//LIM domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.37552 BP_3 125.44 1.49 4361 642914862 XP_008195074.1 2187 7.2e-243 PREDICTED: myosin light chain kinase, smooth muscle-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q6PDN3 828 1.1e-86 Myosin light chain kinase, smooth muscle OS=Mus musculus GN=Mylk PE=1 SV=3 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.37554 BP_3 535.28 2.11 12506 189238427 XP_973569.2 3930 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase DHX34 [Tribolium castaneum]>gi|270008523|gb|EFA04971.1| hypothetical protein TcasGA2_TC015049 [Tribolium castaneum] 642925354 XM_008196294.1 497 0 PREDICTED: Tribolium castaneum integrator complex subunit 2 (LOC661595), mRNA K13139 INTS2 integrator complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13139 Q14147 2048 1.1e-227 Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens GN=DHX34 PE=1 SV=2 PF07527//PF00270//PF14750//PF04851//PF03391//PF00023//PF02399//PF04408//PF13606 Hairy Orange//DEAD/DEAH box helicase//Integrator complex subunit 2//Type III restriction enzyme, res subunit//Nepovirus coat protein, central domain//Ankyrin repeat//Origin of replication binding protein//Helicase associated domain (HA2)//Ankyrin repeat GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003676//GO:0005198//GO:0008026//GO:0005515//GO:0005524//GO:0003688//GO:0004386//GO:0003677//GO:0016787 nucleic acid binding//structural molecule activity//ATP-dependent helicase activity//protein binding//ATP binding//DNA replication origin binding//helicase activity//DNA binding//hydrolase activity GO:0046809//GO:0019028//GO:0032039 replication compartment//viral capsid//integrator complex -- -- Cluster-8309.37555 BP_3 60.54 0.54 5727 642926029 XP_969555.3 1435 1.5e-155 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 4.18231e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 3.5e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 PF05456 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) GO:0045947 negative regulation of translational initiation GO:0008190 eukaryotic initiation factor 4E binding -- -- -- -- Cluster-8309.37557 BP_3 38.33 0.33 5946 478255994 ENN76193.1 2025 6.0e-224 hypothetical protein YQE_07161, partial [Dendroctonus ponderosae] -- -- -- -- -- K11423 SETD2, SET2 histone-lysine N-methyltransferase SETD2 http://www.genome.jp/dbget-bin/www_bget?ko:K11423 Q9VYD1 849 5.7e-89 Probable histone-lysine N-methyltransferase CG1716 OS=Drosophila melanogaster GN=Set2 PE=1 SV=2 PF00397//PF15761//PF00856 WW domain//Immortalisation up-regulated protein//SET domain -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.37559 BP_3 286.85 1.91 7521 642924959 XP_008194115.1 2881 0.0e+00 PREDICTED: coiled-coil domain-containing protein CG32809 isoform X7 [Tribolium castaneum] 642924968 XM_008195898.1 229 1.71662e-113 PREDICTED: Tribolium castaneum coiled-coil domain-containing protein AGAP005037 (LOC100141714), transcript variant X12, mRNA -- -- -- -- Q7PQ25 1217 1.5e-131 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF07989//PF02970//PF07945//PF01025 Centrosomin N-terminal motif 1//Tubulin binding cofactor A//Janus-atracotoxin//GrpE GO:0009405//GO:0006457//GO:0007021 pathogenesis//protein folding//tubulin complex assembly GO:0015631//GO:0051087//GO:0042803//GO:0051082//GO:0000774 tubulin binding//chaperone binding//protein homodimerization activity//unfolded protein binding//adenyl-nucleotide exchange factor activity GO:0045298//GO:0005815//GO:0005576 tubulin complex//microtubule organizing center//extracellular region -- -- Cluster-8309.3756 BP_3 2.00 0.45 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37560 BP_3 1310.07 45.52 1679 478255276 ENN75505.1 1901 4.0e-210 hypothetical protein YQE_08054, partial [Dendroctonus ponderosae]>gi|546677636|gb|ERL88437.1| hypothetical protein D910_05823 [Dendroctonus ponderosae] -- -- -- -- -- K02358 tuf, TUFM elongation factor Tu http://www.genome.jp/dbget-bin/www_bget?ko:K02358 P49411 1336 5.4e-146 Elongation factor Tu, mitochondrial OS=Homo sapiens GN=TUFM PE=1 SV=2 PF03144//PF01926//PF10662 Elongation factor Tu domain 2//50S ribosome-binding GTPase//Ethanolamine utilisation - propanediol utilisation GO:0006576 cellular biogenic amine metabolic process GO:0005524//GO:0005525 ATP binding//GTP binding -- -- KOG0460 Mitochondrial translation elongation factor Tu Cluster-8309.37561 BP_3 89.18 0.52 8551 642911061 XP_008200558.1 3908 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2982 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00520//PF00813 Ion transport protein//FliP family GO:0006811//GO:0009306//GO:0055085 ion transport//protein secretion//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.37565 BP_3 2864.69 43.24 3485 642928992 XP_008195647.1 1707 2.6e-187 PREDICTED: endoplasmic reticulum metallopeptidase 1-like [Tribolium castaneum] 642930260 XM_966256.3 107 5.2215e-46 PREDICTED: Tribolium castaneum 40S ribosomal protein S29 (LOC659992), mRNA -- -- -- -- Q3UVK0 775 1.3e-80 Endoplasmic reticulum metallopeptidase 1 OS=Mus musculus GN=Ermp1 PE=2 SV=2 PF15168//PF00253//PF01546 Triple QxxK/R motif-containing protein family//Ribosomal protein S14p/S29e//Peptidase family M20/M25/M40 GO:0042254//GO:0008152//GO:0006412 ribosome biogenesis//metabolic process//translation GO:0003735//GO:0016787 structural constituent of ribosome//hydrolase activity GO:0005840//GO:0005622//GO:0005789 ribosome//intracellular//endoplasmic reticulum membrane KOG2194 Aminopeptidases of the M20 family Cluster-8309.37566 BP_3 92.79 0.74 6303 847542679 CDI30232.1 3007 0.0e+00 Insulin Receptor [Blattella germanica] 887513390 KP331063.1 128 2.00965e-57 Leptinotarsa decemlineata insulin-like receptor (INR) mRNA, complete cds K05086 INSRR insulin receptor-related receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05086 P14617 2072 9.2e-231 Insulin receptor-related protein OS=Cavia porcellus GN=INSRR PE=3 SV=1 PF00069//PF07714//PF16656//PF00757//PF00041 Protein kinase domain//Protein tyrosine kinase//Purple acid Phosphatase, N-terminal domain//Furin-like cysteine rich region//Fibronectin type III domain GO:0019497//GO:0006468//GO:0007169//GO:0006771 hexachlorocyclohexane metabolic process//protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway//riboflavin metabolic process GO:0005515//GO:0005524//GO:0004714//GO:0046872//GO:0004672//GO:0003993 protein binding//ATP binding//transmembrane receptor protein tyrosine kinase activity//metal ion binding//protein kinase activity//acid phosphatase activity GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.37567 BP_3 3.18 0.46 627 642914876 XP_008190427.1 317 7.1e-27 PREDICTED: tropomyosin alpha-1 chain [Tribolium castaneum]>gi|270001406|gb|EEZ97853.1| hypothetical protein TcasGA2_TC000225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37568 BP_3 451.71 9.57 2566 91077460 XP_967961.1 1258 2.2e-135 PREDICTED: membrane-bound transcription factor site-2 protease [Tribolium castaneum]>gi|270001616|gb|EEZ98063.1| hypothetical protein TcasGA2_TC000469 [Tribolium castaneum] -- -- -- -- -- K07765 MBTPS2 S2P endopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K07765 O54862 544 5.7e-54 Membrane-bound transcription factor site-2 protease OS=Cricetulus griseus GN=MBTPS2 PE=2 SV=1 PF13180//PF02163 PDZ domain//Peptidase family M50 GO:0006508 proteolysis GO:0004222//GO:0005515 metalloendopeptidase activity//protein binding -- -- KOG2921 Intramembrane metalloprotease (sterol-regulatory element-binding protein (SREBP) protease) Cluster-8309.37569 BP_3 218.35 4.32 2727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09207 Yeast killer toxin GO:0009405//GO:0008219 pathogenesis//cell death -- -- GO:0005576 extracellular region -- -- Cluster-8309.37570 BP_3 1305.51 20.31 3390 189235332 XP_001816025.1 646 2.7e-64 PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Tribolium castaneum]>gi|270003646|gb|EFA00094.1| hypothetical protein TcasGA2_TC002909 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13903//PF10204//PF00822//PF00060 PMP-22/EMP/MP20/Claudin tight junction//Dual oxidase maturation factor//PMP-22/EMP/MP20/Claudin family//Ligand-gated ion channel GO:0007268//GO:0007165//GO:0015031//GO:0006811 synaptic transmission//signal transduction//protein transport//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0005789//GO:0016021//GO:0016020 endoplasmic reticulum membrane//integral component of membrane//membrane -- -- Cluster-8309.37572 BP_3 394.69 7.24 2920 642929338 XP_008195792.1 700 1.3e-70 PREDICTED: AMP deaminase 2 isoform X3 [Tribolium castaneum] 194769475 XM_001966794.1 153 1.17176e-71 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 449 6.7e-43 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0019239 metal ion binding//oxidoreductase activity//deaminase activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.37573 BP_3 115.90 1.27 4698 91089655 XP_974084.1 2180 5.0e-242 PREDICTED: protein wntless [Tribolium castaneum]>gi|270011339|gb|EFA07787.1| hypothetical protein TcasGA2_TC005345 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4LC58 1542 2.0e-169 Protein wntless OS=Drosophila virilis GN=wls PE=3 SV=1 PF00651 BTB/POZ domain GO:0016055 Wnt signaling pathway GO:0017147//GO:0005515 Wnt-protein binding//protein binding -- -- -- -- Cluster-8309.37575 BP_3 434.86 2.48 8731 642920269 XP_008192276.1 3095 0.0e+00 PREDICTED: anoctamin-1-like isoform X2 [Tribolium castaneum] 780682419 XM_011699543.1 39 8.32103e-08 PREDICTED: Wasmannia auropunctata anoctamin-1 (LOC105455869), transcript variant X4, mRNA K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q8BHY3 1545 1.6e-169 Anoctamin-1 OS=Mus musculus GN=Ano1 PE=1 SV=2 PF16178//PF13939//PF01091 Dimerisation domain of Ca+-activated chloride-channel, anoctamin//Toxin TisB, type I toxin-antitoxin system//PTN/MK heparin-binding protein family, C-terminal domain GO:0009432//GO:0022611//GO:0006820//GO:0040007//GO:0007165//GO:0008283 SOS response//dormancy process//anion transport//growth//signal transduction//cell proliferation GO:0005253//GO:0008083//GO:0046983 anion channel activity//growth factor activity//protein dimerization activity GO:0005887 integral component of plasma membrane KOG2514 Uncharacterized conserved protein Cluster-8309.37576 BP_3 704.69 7.77 4661 270012529 EFA08977.1 860 5.7e-89 hypothetical protein TcasGA2_TC006684 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37577 BP_3 377.52 2.38 7938 642925217 XP_008194472.1 2663 8.3e-298 PREDICTED: zinc finger protein 729-like isoform X1 [Tribolium castaneum]>gi|270008760|gb|EFA05208.1| hypothetical protein TcasGA2_TC015347 [Tribolium castaneum] 194761711 XM_001963036.1 87 1.56887e-34 Drosophila ananassae GF15759 (Dana\GF15759), mRNA -- -- -- -- Q9VL13 907 1.4e-95 MOB kinase activator-like 3 OS=Drosophila melanogaster GN=Mob3 PE=2 SV=1 PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus KOG1903 Cell cycle-associated protein Cluster-8309.37578 BP_3 1300.00 10.59 6209 642926098 XP_008194783.1 7192 0.0e+00 PREDICTED: uncharacterized protein KIAA1109 [Tribolium castaneum] 194758979 XM_001961698.1 57 5.82701e-18 Drosophila ananassae GF14780 (Dana\GF14780), mRNA -- -- -- -- Q2LD37 1686 5.2e-186 Uncharacterized protein KIAA1109 OS=Homo sapiens GN=KIAA1109 PE=1 SV=2 PF04444 Catechol dioxygenase N terminus GO:0046232//GO:0055114//GO:0042184//GO:0042203//GO:0009712//GO:0019261//GO:0018874 carbazole catabolic process//oxidation-reduction process//xylene catabolic process//toluene catabolic process//catechol-containing compound metabolic process//1,4-dichlorobenzene catabolic process//benzoate metabolic process GO:0005506//GO:0018576 iron ion binding//catechol 1,2-dioxygenase activity -- -- KOG3596 Uncharacterized conserved protein Cluster-8309.37579 BP_3 118.00 15.83 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF08496 Presenilin//Peptidase family S49 N-terminal -- -- GO:0004252//GO:0004190 serine-type endopeptidase activity//aspartic-type endopeptidase activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.37581 BP_3 7015.26 802.62 713 264667389 ACY71280.1 925 2.5e-97 ribosomal protein S7 [Chrysomela tremula] 752878389 XM_011258375.1 129 6.06055e-59 PREDICTED: Camponotus floridanus 40S ribosomal protein S7-like (LOC105251512), mRNA K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 Q962S0 854 1.8e-90 40S ribosomal protein S7 OS=Spodoptera frugiperda GN=RpS7 PE=2 SV=1 PF01251 Ribosomal protein S7e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3320 40S ribosomal protein S7 Cluster-8309.37582 BP_3 447.00 25.40 1140 91075924 XP_966963.1 279 3.3e-22 PREDICTED: cytochrome b-c1 complex subunit 10 [Tribolium castaneum]>gi|270015124|gb|EFA11572.1| hypothetical protein TcasGA2_TC004680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CPX8 140 1.8e-07 Cytochrome b-c1 complex subunit 10 OS=Mus musculus GN=Uqcr11 PE=3 SV=1 PF08997 Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0006118//GO:0006119//GO:0015992 obsolete electron transport//oxidative phosphorylation//proton transport GO:0009055//GO:0008121 electron carrier activity//ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.37583 BP_3 688.01 4.89 7068 642935886 XP_008198213.1 3884 0.0e+00 PREDICTED: sterile alpha and TIR motif-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IDD9 2791 0.0e+00 Sterile alpha and TIR motif-containing protein 1 OS=Drosophila melanogaster GN=Ect4 PE=2 SV=1 PF00514//PF06624//PF00536//PF07647//PF16045//PF13676 Armadillo/beta-catenin-like repeat//Ribosome associated membrane protein RAMP4//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//LisH//TIR domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG3678 SARM protein (with sterile alpha and armadillo motifs) Cluster-8309.37585 BP_3 372.50 3.69 5156 332375044 AEE62663.1 3535 0.0e+00 unknown [Dendroctonus ponderosae]>gi|478250038|gb|ENN70544.1| hypothetical protein YQE_12719, partial [Dendroctonus ponderosae]>gi|546672620|gb|ERL84416.1| hypothetical protein D910_01849 [Dendroctonus ponderosae] 642932042 XM_969767.3 504 0 PREDICTED: Tribolium castaneum probable aconitate hydratase, mitochondrial (LOC663732), mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 Q99KI0 3035 0.0e+00 Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1 PF00330//PF00694 Aconitase family (aconitate hydratase)//Aconitase C-terminal domain GO:0008152 metabolic process -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.37586 BP_3 2864.30 17.40 8228 478249703 ENN70211.1 3709 0.0e+00 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 Q8R420 1191 1.7e-128 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00448//PF01225//PF06414//PF13304//PF00005//PF03193 SRP54-type protein, GTPase domain//Mur ligase family, catalytic domain//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 GO:0006614//GO:0009058 SRP-dependent cotranslational protein targeting to membrane//biosynthetic process GO:0016301//GO:0016887//GO:0005525//GO:0005524//GO:0003924 kinase activity//ATPase activity//GTP binding//ATP binding//GTPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.37588 BP_3 2657.37 21.29 6309 478249703 ENN70211.1 1984 3.6e-219 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05642 ABCA2 ATP-binding cassette, subfamily A (ABC1), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05642 Q9ESR9 982 2.3e-104 ATP-binding cassette sub-family A member 2 OS=Rattus norvegicus GN=Abca2 PE=1 SV=1 PF06414//PF13304//PF03193//PF00005//PF01312//PF01225 Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function, DUF258//ABC transporter//FlhB HrpN YscU SpaS Family//Mur ligase family, catalytic domain GO:0009306//GO:0009058 protein secretion//biosynthetic process GO:0003924//GO:0005524//GO:0005525//GO:0016301//GO:0016887 GTPase activity//ATP binding//GTP binding//kinase activity//ATPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.37590 BP_3 190.25 1.44 6648 675381743 KFM74645.1 363 3.5e-31 Zinc finger protein 729, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A0JNB1 314 6.9e-27 Zinc finger protein 227 OS=Bos taurus GN=ZNF227 PE=2 SV=1 PF13465//PF07535//PF04810//PF06305//PF00412//PF02892//PF13912//PF01428//PF16622//PF00096 Zinc-finger double domain//DBF zinc finger//Sec23/Sec24 zinc finger//Protein of unknown function (DUF1049)//LIM domain//BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270//GO:0046872//GO:0003677 nucleic acid binding//zinc ion binding//metal ion binding//DNA binding GO:0005887//GO:0030127 integral component of plasma membrane//COPII vesicle coat -- -- Cluster-8309.37591 BP_3 368.61 9.81 2103 91092778 XP_973837.1 667 6.2e-67 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.37594 BP_3 160.60 1.16 6954 546679508 ERL89967.1 2307 1.4e-256 hypothetical protein D910_07326 [Dendroctonus ponderosae] 642937940 XM_001807052.2 505 0 PREDICTED: Tribolium castaneum sodium/hydrogen exchanger 8 (LOC100141996), mRNA K14724 SLC9A8, NHE8 solute carrier family 9 (sodium/hydrogen exchanger), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14724 Q5ZJ75 1410 5.9e-154 Sodium/hydrogen exchanger 8 OS=Gallus gallus PE=2 SV=1 PF00999//PF06699//PF02615 Sodium/hydrogen exchanger family//GPI biosynthesis protein family Pig-F//Malate/L-lactate dehydrogenase GO:0055085//GO:0008152//GO:0006506//GO:0006885//GO:0006812//GO:0055114 transmembrane transport//metabolic process//GPI anchor biosynthetic process//regulation of pH//cation transport//oxidation-reduction process GO:0015299//GO:0016491 solute:proton antiporter activity//oxidoreductase activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.37596 BP_3 612.97 11.19 2932 91091818 XP_966528.1 2047 8.2e-227 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 1305 3.7e-142 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF03594//PF02321//PF00060//PF10613 Benzoate membrane transport protein//Outer membrane efflux protein//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0006810//GO:0007268//GO:0042919//GO:0007165//GO:0006811 transport//synaptic transmission//benzoate transport//signal transduction//ion transport GO:0005234//GO:0004970//GO:0005215//GO:0042925//GO:0005216 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//transporter activity//benzoate transporter activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.37597 BP_3 1914.00 19.87 4934 270010525 EFA06973.1 577 4.0e-56 hypothetical protein TcasGA2_TC009933 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI6 341 3.8e-30 Transcription factor CP2-like protein 1 OS=Homo sapiens GN=TFCP2L1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37598 BP_3 8611.50 169.40 2742 189236107 XP_973934.2 817 3.3e-84 PREDICTED: high mobility group protein DSP1-like [Tribolium castaneum] 642918928 XM_968841.3 235 2.86828e-117 PREDICTED: Tribolium castaneum high mobility group protein DSP1-like (LOC662763), mRNA K10802 HMGB1 high mobility group protein B1 http://www.genome.jp/dbget-bin/www_bget?ko:K10802 Q24537 690 7.2e-71 High mobility group protein DSP1 OS=Drosophila melanogaster GN=Dsp1 PE=2 SV=1 PF15761//PF09606//PF04961 Immortalisation up-regulated protein//ARC105 or Med15 subunit of Mediator complex non-fungal//Formiminotransferase-cyclodeaminase GO:0006357//GO:0044237 regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0001104 catalytic activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005634 mediator complex//nucleus KOG0381 HMG box-containing protein Cluster-8309.37599 BP_3 551.00 10.26 2879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15245 Transcription cofactor vestigial-like protein 4 GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.37600 BP_3 21266.95 77.66 13491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00770//PF05493 Adenovirus endoprotease//ATP synthase subunit H GO:0015992//GO:0015991//GO:0006508 proton transport//ATP hydrolysis coupled proton transport//proteolysis GO:0004197//GO:0015078 cysteine-type endopeptidase activity//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.37601 BP_3 617.96 14.35 2367 642929146 XP_008195713.1 1136 2.9e-121 PREDICTED: quaking related isoform X1 [Tribolium castaneum] -- -- -- -- -- K17843 KHDRBS2, SLM1 KH domain-containing, RNA-binding, signal transduction-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17843 Q920F3 502 3.9e-49 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Rattus norvegicus GN=Khdrbs2 PE=1 SV=1 PF13014//PF00013 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.37602 BP_3 10838.60 252.71 2359 240849263 NP_001155531.1 702 6.1e-71 V-type proton ATPase 16 kDa proteolipid subunit [Acyrthosiphon pisum]>gi|239790001|dbj|BAH71590.1| ACYPI003545 [Acyrthosiphon pisum] 642937690 XM_962866.3 207 9.05276e-102 PREDICTED: Tribolium castaneum V-type proton ATPase 16 kDa proteolipid subunit (LOC656327), mRNA K02155 ATPeV0C, ATP6L V-type H+-transporting ATPase 16kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02155 P23380 685 2.3e-70 V-type proton ATPase 16 kDa proteolipid subunit OS=Drosophila melanogaster GN=Vha16-1 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179//GO:0016021//GO:0033177 proton-transporting V-type ATPase, V0 domain//integral component of membrane//proton-transporting two-sector ATPase complex, proton-transporting domain KOG0232 Vacuolar H+-ATPase V0 sector, subunits c/c' Cluster-8309.37603 BP_3 1725.63 27.33 3335 642928315 XP_008195531.1 1039 7.2e-110 PREDICTED: microtubule-associated protein RP/EB family member 1 [Tribolium castaneum] 817062491 XM_012397482.1 89 5.06558e-36 PREDICTED: Athalia rosae microtubule-associated protein RP/EB family member 1 (LOC105684257), transcript variant X6, mRNA K10436 MAPRE microtubule-associated protein, RP/EB family http://www.genome.jp/dbget-bin/www_bget?ko:K10436 Q66T82 749 1.3e-77 Microtubule-associated protein RP/EB family member 1 OS=Coturnix coturnix japonica GN=MAPRE1 PE=2 SV=1 PF00307//PF03271//PF05361//PF06070 Calponin homology (CH) domain//EB1-like C-terminal motif//PKC-activated protein phosphatase-1 inhibitor//Herpesvirus large structural phosphoprotein UL32 GO:0042325 regulation of phosphorylation GO:0008017//GO:0005198//GO:0005515 microtubule binding//structural molecule activity//protein binding GO:0005737//GO:0045298 cytoplasm//tubulin complex KOG3000 Microtubule-binding protein involved in cell cycle control Cluster-8309.37605 BP_3 8034.42 105.51 3962 546676342 ERL87369.1 868 5.8e-90 hypothetical protein D910_04764 [Dendroctonus ponderosae] -- -- -- -- -- K17987 NBR1 next to BRCA1 gene 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K17987 Q5RC94 190 9.8e-13 Next to BRCA1 gene 1 protein OS=Pongo abelii GN=NBR1 PE=2 SV=1 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.37607 BP_3 3844.54 138.26 1632 270016295 EFA12741.1 1660 3.4e-182 Rm62 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.77927e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1365 2.3e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF03141//PF04851//PF00270 Putative S-adenosyl-L-methionine-dependent methyltransferase//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0005524//GO:0008168//GO:0003676//GO:0016787//GO:0003677 ATP binding//methyltransferase activity//nucleic acid binding//hydrolase activity//DNA binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.37608 BP_3 1439.55 234.15 588 478250527 ENN71022.1 259 3.5e-20 hypothetical protein YQE_12421, partial [Dendroctonus ponderosae]>gi|546678988|gb|ERL89521.1| hypothetical protein D910_06887 [Dendroctonus ponderosae] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 Q501J6 143 4.1e-08 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF03396 Poxvirus DNA-directed RNA polymerase, 35 kD subunit GO:0019083//GO:0006206//GO:0006351//GO:0006144 viral transcription//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG0331 ATP-dependent RNA helicase Cluster-8309.37609 BP_3 243.65 2.52 4953 642916747 XP_972619.2 2242 3.4e-249 PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916749|ref|XP_008192467.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916751|ref|XP_008192470.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04422 MAP3K13, LZK mitogen-activated protein kinase kinase kinase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K04422 Q12852 1037 7.5e-111 Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens GN=MAP3K12 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG4721 Serine/threonine protein kinase, contains leucine zipper domain Cluster-8309.3761 BP_3 15.00 1.20 893 33096741 CAE11873.1 1196 1.2e-128 hypothetical protein [Homo sapiens] 16740988 BC016346.1 871 0 Homo sapiens ferritin, light polypeptide, mRNA (cDNA clone MGC:24392 IMAGE:4066010), complete cds K13625 FTL ferritin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K13625 P02792 842 5.5e-89 Ferritin light chain OS=Homo sapiens GN=FTL PE=1 SV=2 PF00210 Ferritin-like domain GO:0006879 cellular iron ion homeostasis GO:0008199 ferric iron binding -- -- -- -- Cluster-8309.37611 BP_3 364.07 6.05 3194 642910245 XP_008198545.1 580 1.2e-56 PREDICTED: protein pygopus isoform X2 [Tribolium castaneum] 241695262 XM_002412985.1 132 6.05468e-60 Ixodes scapularis pygopus, putative, mRNA -- -- -- -- Q9V9W8 427 2.6e-40 Protein pygopus OS=Drosophila melanogaster GN=pygo PE=1 SV=1 PF00075//PF13639//PF17123//PF00628//PF02121 RNase H//Ring finger domain//RING-like zinc finger//PHD-finger//Phosphatidylinositol transfer protein GO:0051252//GO:0006810 regulation of RNA metabolic process//transport GO:0004523//GO:0005515//GO:0008270//GO:0003676 RNA-DNA hybrid ribonuclease activity//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.37612 BP_3 252.50 4.20 3188 642910245 XP_008198545.1 635 4.8e-63 PREDICTED: protein pygopus isoform X2 [Tribolium castaneum] 241695262 XM_002412985.1 132 6.04318e-60 Ixodes scapularis pygopus, putative, mRNA -- -- -- -- Q9V9W8 437 1.8e-41 Protein pygopus OS=Drosophila melanogaster GN=pygo PE=1 SV=1 PF17123//PF00628//PF02121//PF00075//PF13639 RING-like zinc finger//PHD-finger//Phosphatidylinositol transfer protein//RNase H//Ring finger domain GO:0051252//GO:0006810 regulation of RNA metabolic process//transport GO:0004523//GO:0005515//GO:0008270//GO:0003676 RNA-DNA hybrid ribonuclease activity//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.37613 BP_3 45.48 0.47 4987 91085983 XP_972029.1 1866 1.4e-205 PREDICTED: TBC1 domain family member 31 [Tribolium castaneum]>gi|270010179|gb|EFA06627.1| hypothetical protein TcasGA2_TC009546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DN5 1041 2.6e-111 TBC1 domain family member 31 OS=Homo sapiens GN=TBC1D31 PE=2 SV=2 PF03091//PF00156//PF03310//PF06689 CutA1 divalent ion tolerance protein//Phosphoribosyl transferase domain//Caulimovirus DNA-binding protein//ClpX C4-type zinc finger GO:0010038//GO:0009116 response to metal ion//nucleoside metabolic process GO:0003677//GO:0008270//GO:0046983 DNA binding//zinc ion binding//protein dimerization activity -- -- KOG1712 Adenine phosphoribosyl transferases Cluster-8309.37614 BP_3 1259.00 50.43 1495 197313765 NP_001127918.1 502 6.0e-48 uncharacterized protein LOC100187736 [Tribolium castaneum]>gi|270005547|gb|EFA01995.1| hypothetical protein TcasGA2_TC007616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37617 BP_3 990.00 34.95 1657 332374372 AEE62327.1 1218 6.3e-131 unknown [Dendroctonus ponderosae]>gi|478257069|gb|ENN77232.1| hypothetical protein YQE_06062, partial [Dendroctonus ponderosae] -- -- -- -- -- K09554 CDC37 cell division cycle protein 37 http://www.genome.jp/dbget-bin/www_bget?ko:K09554 Q24276 1052 4.6e-113 Hsp90 co-chaperone Cdc37 OS=Drosophila melanogaster GN=Cdc37 PE=1 SV=1 PF03234 Cdc37 N terminal kinase binding -- -- GO:0019901 protein kinase binding -- -- KOG2260 Cell division cycle 37 protein, CDC37 Cluster-8309.37618 BP_3 123.83 2.80 2426 91089929 XP_973045.1 413 2.0e-37 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04309//PF00436 Glycerol-3-phosphate responsive antiterminator//Single-strand binding protein family GO:0009607//GO:0006355 response to biotic stimulus//regulation of transcription, DNA-templated GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.37619 BP_3 1224.22 4.46 13521 642929047 XP_008195667.1 13180 0.0e+00 PREDICTED: baculoviral IAP repeat-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10586 BIRC6, BRUCE baculoviral IAP repeat-containing protein 6 (apollon) http://www.genome.jp/dbget-bin/www_bget?ko:K10586 O88738 3109 0.0e+00 Baculoviral IAP repeat-containing protein 6 OS=Mus musculus GN=Birc6 PE=1 SV=2 PF12356//PF00844 Protein of unknown function (DUF3643)//Geminivirus coat protein/nuclear export factor BR1 family GO:0016567//GO:0006915//GO:0032465 protein ubiquitination//apoptotic process//regulation of cytokinesis GO:0005198//GO:0004842 structural molecule activity//ubiquitin-protein transferase activity GO:0019028 viral capsid KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.37621 BP_3 51.15 1.07 2594 642913818 XP_008201172.1 643 4.6e-64 PREDICTED: myosin light chain alkali isoform X1 [Tribolium castaneum] 642913817 XM_008202950.1 253 2.6752e-127 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 455 1.2e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF00036//PF13405//PF13499 EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.37622 BP_3 112.55 1.12 5148 91086147 XP_969343.1 2917 0.0e+00 PREDICTED: integrator complex subunit 11 [Tribolium castaneum]>gi|270009886|gb|EFA06334.1| hypothetical protein TcasGA2_TC009205 [Tribolium castaneum] 826440986 XM_012674849.1 377 0 PREDICTED: Monomorium pharaonis integrator complex subunit 11 (LOC105833262), transcript variant X4, mRNA K13148 CPSF3L, INTS11 integrator complex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13148 Q5ZIH0 2284 2.0e-255 Integrator complex subunit 11 OS=Gallus gallus GN=CPSF3L PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.37623 BP_3 348.00 11.54 1745 478263358 ENN81734.1 388 1.2e-34 hypothetical protein YQE_01873, partial [Dendroctonus ponderosae]>gi|546681306|gb|ERL91420.1| hypothetical protein D910_08752 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0030431//GO:1903818//GO:0032222 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.37625 BP_3 264.49 3.03 4495 642913077 XP_008201380.1 1635 7.5e-179 PREDICTED: disks large 1 tumor suppressor protein isoform X4 [Tribolium castaneum] 462373132 APGK01024854.1 117 1.86368e-51 Dendroctonus ponderosae Seq01024864, whole genome shotgun sequence K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 1160 3.7e-125 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00018//PF14604//PF00595 PDZ domain//SH3 domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.37627 BP_3 19.64 1.64 869 642913083 XP_008201383.1 736 2.6e-75 PREDICTED: disks large 1 tumor suppressor protein isoform X7 [Tribolium castaneum] 642913082 XM_008203161.1 259 4.03392e-131 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X7, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 321 1.4e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.37628 BP_3 611.96 2.32 12995 270007354 EFA03802.1 5836 0.0e+00 hypothetical protein TcasGA2_TC013915 [Tribolium castaneum] 642917043 XM_008192874.1 352 0 PREDICTED: Tribolium castaneum diacylglycerol kinase eta-like (LOC103312380), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 B4K6T8 2049 8.8e-228 Diacylglycerol kinase eta OS=Drosophila mojavensis GN=GI24133 PE=3 SV=1 PF02198//PF16866//PF07649//PF00749//PF07647//PF02017//PF00536//PF00130//PF00609//PF00781 Sterile alpha motif (SAM)/Pointed domain//PHD-finger//C1-like domain//tRNA synthetases class I (E and Q), catalytic domain//SAM domain (Sterile alpha motif)//CIDE-N domain//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//Diacylglycerol kinase catalytic domain GO:0007205//GO:0009395//GO:0043039//GO:0055114//GO:0035556//GO:0046486//GO:0006915 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//tRNA aminoacylation//oxidation-reduction process//intracellular signal transduction//glycerolipid metabolic process//apoptotic process GO:0005515//GO:0004143//GO:0005524//GO:0016876//GO:0047134//GO:0043565//GO:0016301 protein binding//diacylglycerol kinase activity//ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//protein-disulfide reductase activity//sequence-specific DNA binding//kinase activity GO:0005634//GO:0005622 nucleus//intracellular KOG1170 Diacylglycerol kinase Cluster-8309.37629 BP_3 11387.19 877.80 917 91076492 XP_972907.1 875 2.1e-91 PREDICTED: 60S ribosomal protein L18a [Tribolium castaneum]>gi|270002411|gb|EEZ98858.1| hypothetical protein TcasGA2_TC004468 [Tribolium castaneum] 815769202 XM_012379287.1 145 1.0052e-67 PREDICTED: Linepithema humile 60S ribosomal protein L18a (LOC105679340), mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q8WQI7 768 2.2e-80 60S ribosomal protein L18a OS=Spodoptera frugiperda GN=RpL18A PE=2 SV=1 PF01775//PF09004 Ribosomal L18ae/LX protein domain//Domain of unknown function (DUF1891) GO:0055114//GO:0042254//GO:0006412 oxidation-reduction process//ribosome biogenesis//translation GO:0008168//GO:0003735//GO:0016706 methyltransferase activity//structural constituent of ribosome//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.37632 BP_3 2294.55 25.65 4603 642917716 XP_008191343.1 3538 0.0e+00 PREDICTED: ecotropic viral integration site 5 ortholog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VYY9 2243 1.0e-250 Ecotropic viral integration site 5 ortholog OS=Drosophila melanogaster GN=Evi5 PE=1 SV=3 PF13013 F-box-like domain -- -- GO:0005515 protein binding -- -- KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.37634 BP_3 6.07 0.51 861 91081785 XP_973657.1 511 3.1e-49 PREDICTED: putative E3 ubiquitin-protein ligase UBR7 [Tribolium castaneum]>gi|270005043|gb|EFA01491.1| hypothetical protein TcasGA2_TC007045 [Tribolium castaneum] -- -- -- -- -- K11979 UBR7 E3 ubiquitin-protein ligase UBR7 http://www.genome.jp/dbget-bin/www_bget?ko:K11979 Q8N806 272 6.6e-23 Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens GN=UBR7 PE=1 SV=2 -- -- GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding -- -- KOG2752 Uncharacterized conserved protein, contains N-recognin-type Zn-finger Cluster-8309.37635 BP_3 975.67 19.56 2696 123227460 CAM27169.1 262 7.3e-20 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] -- -- -- -- -- K13943 CBT cabut http://www.genome.jp/dbget-bin/www_bget?ko:K13943 Q05481 238 1.8e-18 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.37637 BP_3 2360.56 34.76 3565 189238905 XP_967915.2 2699 2.5e-302 PREDICTED: influenza virus NS1A-binding protein-like [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 1007 1.6e-107 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.37638 BP_3 7.00 0.45 1042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37639 BP_3 23065.12 293.08 4085 91082899 XP_972170.1 1166 1.7e-124 PREDICTED: protein spire [Tribolium castaneum]>gi|270008222|gb|EFA04670.1| spire [Tribolium castaneum] 770075505 NM_001305498.1 122 2.81188e-54 Plutella xylostella translationally-controlled tumor protein homolog (LOC105389397), mRNA >gnl|BL_ORD_ID|1274647 Plutella xylostella mRNA for translationally controlled tumor protein, complete cds -- -- -- -- Q75VN3 776 1.1e-80 Translationally-controlled tumor protein homolog OS=Bombyx mori GN=Tctp PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.37641 BP_3 360.55 1.65 10827 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.37643 BP_3 61.00 1.80 1925 189241537 XP_970292.2 1199 1.2e-128 PREDICTED: tropomodulin isoform X2 [Tribolium castaneum] 642936894 XM_008196180.1 371 0 PREDICTED: Tribolium castaneum tropomodulin (LOC658846), transcript variant X5, mRNA K10370 TMOD tropomodulin http://www.genome.jp/dbget-bin/www_bget?ko:K10370 O01479 477 2.5e-46 Tropomodulin OS=Caenorhabditis elegans GN=unc-94 PE=1 SV=2 PF03250 Tropomodulin GO:0051694 pointed-end actin filament capping GO:0005523 tropomyosin binding -- -- KOG3735 Tropomodulin and leiomodulin Cluster-8309.37646 BP_3 232.58 2.36 5034 270003038 EEZ99485.1 388 3.3e-34 hypothetical protein TcasGA2_TC000060 [Tribolium castaneum] -- -- -- -- -- K00791 miaA, TRIT1 tRNA dimethylallyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00791 Q80UN9 283 2.1e-23 tRNA dimethylallyltransferase, mitochondrial OS=Mus musculus GN=Trit1 PE=2 SV=2 PF00096//PF01715 Zinc finger, C2H2 type//IPP transferase GO:0008033 tRNA processing GO:0046872 metal ion binding -- -- KOG1384 tRNA delta(2)-isopentenylpyrophosphate transferase Cluster-8309.37647 BP_3 538.48 10.29 2814 642927608 XP_008195333.1 1642 7.3e-180 PREDICTED: ras-responsive element-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 215 8.8e-16 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF13912//PF11093//PF01428//PF13465//PF00096 C2H2-type zinc finger//Mitochondrial export protein Som1//AN1-like Zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0042720 mitochondrial inner membrane peptidase complex -- -- Cluster-8309.37650 BP_3 2144.09 47.44 2470 546678684 ERL89252.1 394 3.3e-35 hypothetical protein D910_06625 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37652 BP_3 3234.48 22.33 7272 642925954 XP_008195644.1 2092 1.2e-231 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 1367 6.0e-149 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF01480//PF03015//PF01370//PF00309//PF00076//PF00642//PF01073//PF01400//PF01429 PWI domain//Male sterility protein//NAD dependent epimerase/dehydratase family//Sigma-54 factor, Activator interacting domain (AID)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//3-beta hydroxysteroid dehydrogenase/isomerase family//Astacin (Peptidase family M12A)//Methyl-CpG binding domain GO:0006355//GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0006206//GO:0006508//GO:0006352//GO:0006351//GO:0008210//GO:0006397//GO:0006144 regulation of transcription, DNA-templated//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//pyrimidine nucleobase metabolic process//proteolysis//DNA-templated transcription, initiation//transcription, DNA-templated//estrogen metabolic process//mRNA processing//purine nucleobase metabolic process GO:0080019//GO:0003700//GO:0050662//GO:0003854//GO:0004222//GO:0003899//GO:0016616//GO:0016987//GO:0003676//GO:0046872//GO:0003824//GO:0003677 fatty-acyl-CoA reductase (alcohol-forming) activity//transcription factor activity, sequence-specific DNA binding//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//metalloendopeptidase activity//DNA-directed RNA polymerase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//sigma factor activity//nucleic acid binding//metal ion binding//catalytic activity//DNA binding GO:0005730//GO:0005634//GO:0005667 nucleolus//nucleus//transcription factor complex KOG1221 Acyl-CoA reductase Cluster-8309.37653 BP_3 209.69 2.10 5099 478263483 ENN81838.1 154 4.6e-07 hypothetical protein YQE_01777, partial [Dendroctonus ponderosae]>gi|546685487|gb|ERL94985.1| hypothetical protein D910_12257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37656 BP_3 2150.71 29.62 3792 270010125 EFA06573.1 1630 2.4e-178 hypothetical protein TcasGA2_TC009484 [Tribolium castaneum] 642927258 XM_969189.2 206 5.26055e-101 PREDICTED: Tribolium castaneum uncharacterized LOC663129 (LOC663129), mRNA K17776 MTX metaxin http://www.genome.jp/dbget-bin/www_bget?ko:K17776 Q2L969 681 1.1e-69 Metaxin-2 OS=Sus scrofa GN=MTX2 PE=2 SV=1 PF10568//PF13903 Outer mitochondrial membrane transport complex protein//PMP-22/EMP/MP20/Claudin tight junction GO:0006626 protein targeting to mitochondrion -- -- GO:0005741//GO:0016021 mitochondrial outer membrane//integral component of membrane KOG3027 Mitochondrial outer membrane protein Metaxin 2, Metaxin 1-binding protein Cluster-8309.37657 BP_3 511.31 4.66 5581 478250929 ENN71414.1 1135 8.9e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.27137e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF00852//PF04889//PF00956//PF03606 Glycosyltransferase family 10 (fucosyltransferase) C-term//Cwf15/Cwc15 cell cycle control protein//Nucleosome assembly protein (NAP)//C4-dicarboxylate anaerobic carrier GO:0006334//GO:0000398//GO:0006486 nucleosome assembly//mRNA splicing, via spliceosome//protein glycosylation GO:0008417 fucosyltransferase activity GO:0005681//GO:0016021//GO:0005634//GO:0016020 spliceosomal complex//integral component of membrane//nucleus//membrane KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.37662 BP_3 45.57 0.43 5357 642930595 XP_001807608.2 1374 1.6e-148 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00240//PF10410//PF03091 Ubiquitin family//DnaB-helicase binding domain of primase//CutA1 divalent ion tolerance protein GO:0010038 response to metal ion GO:0005515//GO:0016779 protein binding//nucleotidyltransferase activity -- -- -- -- Cluster-8309.37663 BP_3 185.40 1.90 5002 91084021 XP_975350.1 2492 3.5e-278 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 571571862 XM_006564848.1 555 0 PREDICTED: Apis mellifera uncharacterized LOC551823 (LOC551823), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q9BUQ8 2076 2.5e-231 Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens GN=DDX23 PE=1 SV=3 PF00176//PF04851//PF00270//PF06862 SNF2 family N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524//GO:0008026 DNA binding//hydrolase activity//nucleic acid binding//ATP binding//ATP-dependent helicase activity GO:0005634 nucleus KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.37665 BP_3 26.40 27.14 330 264667449 ACY71310.1 319 2.2e-27 ribosomal protein L38 [Chrysomela tremula] 755959155 XM_011306001.1 54 1.30559e-17 PREDICTED: Fopius arisanus 60S ribosomal protein L38 (LOC105267271), mRNA K02923 RP-L38e, RPL38 large subunit ribosomal protein L38e http://www.genome.jp/dbget-bin/www_bget?ko:K02923 Q4GX86 310 9.9e-28 60S ribosomal protein L38 OS=Timarcha balearica GN=RpL38 PE=3 SV=1 PF01781 Ribosomal L38e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3499 60S ribosomal protein L38 Cluster-8309.37667 BP_3 339.76 13.69 1488 91082001 XP_969328.1 930 1.4e-97 PREDICTED: vacuolar protein sorting-associated protein 37A [Tribolium castaneum]>gi|270007313|gb|EFA03761.1| hypothetical protein TcasGA2_TC013872 [Tribolium castaneum] -- -- -- -- -- K12185 VPS37 ESCRT-I complex subunit VPS37 http://www.genome.jp/dbget-bin/www_bget?ko:K12185 Q8NEZ2 283 6.1e-24 Vacuolar protein sorting-associated protein 37A OS=Homo sapiens GN=VPS37A PE=1 SV=1 PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- KOG3270 Uncharacterized conserved protein Cluster-8309.37668 BP_3 108.51 2.03 2869 554879894 XP_005949741.1 566 4.4e-55 PREDICTED: zinc finger protein 585B-like [Haplochromis burtoni] 815905920 XM_012383378.1 159 5.31751e-75 PREDICTED: Bombus impatiens another transcription unit protein (LOC100742825), transcript variant X2, mRNA K15177 LEO1 RNA polymerase-associated protein LEO1 http://www.genome.jp/dbget-bin/www_bget?ko:K15177 O75437 524 1.3e-51 Zinc finger protein 254 OS=Homo sapiens GN=ZNF254 PE=2 SV=3 PF13465//PF07975//PF13912//PF01363//PF04004//PF02892//PF04810//PF16622//PF00346//PF05191//PF00096//PF00130//PF06397//PF16866 Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//FYVE zinc finger//Leo1-like protein//BED zinc finger//Sec23/Sec24 zinc finger//zinc-finger C2H2-type//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Desulfoferrodoxin, N-terminal domain//PHD-finger GO:0006886//GO:0006281//GO:0046034//GO:0016570//GO:0055114//GO:0035556//GO:0006888//GO:0006368//GO:0006144 intracellular protein transport//DNA repair//ATP metabolic process//histone modification//oxidation-reduction process//intracellular signal transduction//ER to Golgi vesicle-mediated transport//transcription elongation from RNA polymerase II promoter//purine nucleobase metabolic process GO:0008270//GO:0004017//GO:0005506//GO:0048038//GO:0003677//GO:0016651//GO:0005515//GO:0051287//GO:0046872 zinc ion binding//adenylate kinase activity//iron ion binding//quinone binding//DNA binding//oxidoreductase activity, acting on NAD(P)H//protein binding//NAD binding//metal ion binding GO:0016593//GO:0030127 Cdc73/Paf1 complex//COPII vesicle coat -- -- Cluster-8309.37669 BP_3 29.60 0.85 1979 264667437 ACY71304.1 658 6.5e-66 ribosomal protein S17 [Chrysomela tremula] 780657916 XM_011693770.1 153 7.90089e-72 PREDICTED: Wasmannia auropunctata 40S ribosomal protein S17 (LOC105452559), mRNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 Q962R2 595 5.4e-60 40S ribosomal protein S17 OS=Spodoptera frugiperda GN=RpS17 PE=2 SV=3 PF02175//PF00833 Serpentine type 7TM GPCR chemoreceptor Srb//Ribosomal S17 GO:0007606//GO:0042254//GO:0007165//GO:0006412 sensory perception of chemical stimulus//ribosome biogenesis//signal transduction//translation GO:0003735//GO:0004888 structural constituent of ribosome//transmembrane signaling receptor activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG0187 40S ribosomal protein S17 Cluster-8309.37670 BP_3 12237.29 46.02 13108 642920090 XP_008192200.1 2117 2.8e-234 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920091 XM_970322.3 333 4.60858e-171 PREDICTED: Tribolium castaneum 40S ribosomal protein S2 (LOC664315), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q5RBG4 1506 8.2e-165 Histone acetyltransferase KAT5 OS=Pongo abelii GN=KAT5 PE=2 SV=1 PF03719//PF13855//PF00560//PF01853//PF05261//PF00583//PF13508//PF00333 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//Leucine Rich Repeat//MOZ/SAS family//TraM protein, DNA-binding//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Ribosomal protein S5, N-terminal domain GO:0006355//GO:0042254//GO:0000746//GO:0042967//GO:0006412 regulation of transcription, DNA-templated//ribosome biogenesis//conjugation//acyl-carrier-protein biosynthetic process//translation GO:0003735//GO:0016747//GO:0003723//GO:0003677//GO:0008080//GO:0005515 structural constituent of ribosome//transferase activity, transferring acyl groups other than amino-acyl groups//RNA binding//DNA binding//N-acetyltransferase activity//protein binding GO:0005840//GO:0005634 ribosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.37671 BP_3 48.30 2.70 1154 642929992 XP_975639.2 444 2.5e-41 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6V5K9 261 1.7e-21 Zinc finger protein 474 OS=Mus musculus GN=Znf474 PE=2 SV=2 PF05191//PF00096 Adenylate kinase, active site lid//Zinc finger, C2H2 type GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.37673 BP_3 115.44 0.90 6470 820805566 AKG92774.1 1694 1.6e-185 clockwork orange [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q5R4R3 566 4.0e-56 Prolyl 3-hydroxylase OGFOD1 OS=Pongo abelii GN=OGFOD1 PE=2 SV=1 PF10637//PF13640//PF00010//PF07527 Oxoglutarate and iron-dependent oxygenase degradation C-term//2OG-Fe(II) oxygenase superfamily//Helix-loop-helix DNA-binding domain//Hairy Orange GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0031418//GO:0016706//GO:0005506//GO:0003677//GO:0016491//GO:0046983 L-ascorbic acid binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron ion binding//DNA binding//oxidoreductase activity//protein dimerization activity -- -- -- -- Cluster-8309.37674 BP_3 64.70 0.55 5984 642919151 XP_008191758.1 2968 0.0e+00 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] 821465109 XM_003759914.2 38 2.04815e-07 PREDICTED: Sarcophilus harrisii complement component 6 (C6), mRNA -- -- -- -- O88307 1793 2.0e-198 Sortilin-related receptor OS=Mus musculus GN=Sorl1 PE=1 SV=3 PF00057//PF04345//PF00041//PF11057 Low-density lipoprotein receptor domain class A//Chorismate lyase//Fibronectin type III domain//Cortexin of kidney GO:0006744 ubiquinone biosynthetic process GO:0005515//GO:0008813 protein binding//chorismate lyase activity GO:0005737//GO:0031224 cytoplasm//intrinsic component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.37675 BP_3 45.65 1.45 1805 332376226 AEE63253.1 1767 1.5e-194 unknown [Dendroctonus ponderosae] 282158080 NM_001170613.1 385 0 Tribolium castaneum arrestin 2 (Arr2), mRNA K13805 ARR2 arrestin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13805 P32122 1583 1.3e-174 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.37677 BP_3 2711.17 4.87 27098 642915997 XP_008190849.1 3577 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02224 247 1.7e-18 Centromere-associated protein E OS=Homo sapiens GN=CENPE PE=1 SV=2 PF02629//PF02444//PF05280 CoA binding domain//Hepatitis E virus ORF-2 (Putative capsid protein)//Flagellar transcriptional activator (FlhC) GO:1902208//GO:0045893 regulation of bacterial-type flagellum assembly//positive regulation of transcription, DNA-templated GO:0048037//GO:0003677 cofactor binding//DNA binding GO:0030430 host cell cytoplasm -- -- Cluster-8309.37679 BP_3 1217.02 9.64 6377 642918631 XP_008200395.1 1308 8.8e-141 PREDICTED: serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3 [Tribolium castaneum] 642918632 XM_008202178.1 261 2.36552e-131 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 6 regulatory subunit 3 (LOC655675), transcript variant X5, mRNA K15501 PPP6R3, SAPS3 serine/threonine-protein phosphatase 6 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15501 O75170 775 2.3e-80 Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens GN=PPP6R2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2073 SAP family cell cycle dependent phosphatase-associated protein Cluster-8309.3768 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37680 BP_3 1236.18 11.40 5519 478250929 ENN71414.1 1135 8.8e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.21243e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF00852//PF03606//PF00956//PF04889 Glycosyltransferase family 10 (fucosyltransferase) C-term//C4-dicarboxylate anaerobic carrier//Nucleosome assembly protein (NAP)//Cwf15/Cwc15 cell cycle control protein GO:0006334//GO:0000398//GO:0006486 nucleosome assembly//mRNA splicing, via spliceosome//protein glycosylation GO:0008417 fucosyltransferase activity GO:0005681//GO:0016021//GO:0005634//GO:0016020 spliceosomal complex//integral component of membrane//nucleus//membrane KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.37681 BP_3 1173.70 10.81 5523 478250929 ENN71414.1 1135 8.8e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.21623e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF03606//PF04889//PF00956//PF00852 C4-dicarboxylate anaerobic carrier//Cwf15/Cwc15 cell cycle control protein//Nucleosome assembly protein (NAP)//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486//GO:0000398//GO:0006334 protein glycosylation//mRNA splicing, via spliceosome//nucleosome assembly GO:0008417 fucosyltransferase activity GO:0016020//GO:0016021//GO:0005634//GO:0005681 membrane//integral component of membrane//nucleus//spliceosomal complex KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.37683 BP_3 2607.20 41.77 3300 478256479 ENN76664.1 1700 1.6e-186 hypothetical protein YQE_06843, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q869E1 144 1.8e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37687 BP_3 83.91 0.47 8951 642938747 XP_008199872.1 2423 6.3e-270 PREDICTED: cytosolic purine 5'-nucleotidase isoform X2 [Tribolium castaneum] 41393060 NM_201427.1 39 8.5316e-08 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1766 4.0e-195 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 PF01652 Eukaryotic initiation factor 4E GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.37688 BP_3 10121.00 165.18 3245 91081299 XP_968887.1 2316 5.9e-258 PREDICTED: cleft lip and palate transmembrane protein 1 homolog [Tribolium castaneum]>gi|270006092|gb|EFA02540.1| hypothetical protein TcasGA2_TC008245 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96005 1624 4.2e-179 Cleft lip and palate transmembrane protein 1 OS=Homo sapiens GN=CLPTM1 PE=1 SV=1 PF02740//PF00225//PF13409//PF01529//PF02798//PF13417//PF05602 Colipase, C-terminal domain//Kinesin motor domain//Glutathione S-transferase, N-terminal domain//DHHC palmitoyltransferase//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Cleft lip and palate transmembrane protein 1 (CLPTM1) GO:0007586//GO:0007018//GO:0016042//GO:0007017 digestion//microtubule-based movement//lipid catabolic process//microtubule-based process GO:0003777//GO:0005515//GO:0005524//GO:0008017//GO:0008047//GO:0008270 microtubule motor activity//protein binding//ATP binding//microtubule binding//enzyme activator activity//zinc ion binding GO:0045298//GO:0005874//GO:0016021//GO:0005576 tubulin complex//microtubule//integral component of membrane//extracellular region KOG2489 Transmembrane protein Cluster-8309.37689 BP_3 8534.58 100.67 4378 642933803 XP_008197345.1 467 2.0e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 8.26602e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q9CZG3 131 7.5e-06 COMM domain-containing protein 8 OS=Mus musculus GN=Commd8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37693 BP_3 120.76 0.67 8982 549438543 AGX25160.1 782 1.2e-79 cathepsin B precursor [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9GZM7 534 2.9e-52 Tubulointerstitial nephritis antigen-like OS=Homo sapiens GN=TINAGL1 PE=1 SV=1 PF03051//PF00112//PF01033//PF04218 Peptidase C1-like family//Papain family cysteine protease//Somatomedin B domain//CENP-B N-terminal DNA-binding domain GO:0007165//GO:0006508//GO:0006955 signal transduction//proteolysis//immune response GO:0005044//GO:0003677//GO:0030247//GO:0008234//GO:0004197 scavenger receptor activity//DNA binding//polysaccharide binding//cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37694 BP_3 288.03 1.28 11157 270008334 EFA04782.1 2089 4.2e-231 hypothetical protein TcasGA2_TC030779 [Tribolium castaneum] -- -- -- -- -- K10630 RBCK1, HOIL1 RanBP-type and C3HC4-type zinc finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10630 E6ZIJ1 896 3.8e-94 RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Dicentrarchus labrax GN=rbck1 PE=3 SV=1 PF00240//PF00097//PF00641//PF14634//PF13639//PF09174 Ubiquitin family//Zinc finger, C3HC4 type (RING finger)//Zn-finger in Ran binding protein and others//zinc-RING finger domain//Ring finger domain//Maf1 regulator GO:0016480 negative regulation of transcription from RNA polymerase III promoter GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.37698 BP_3 3660.04 62.35 3121 478255961 ENN76162.1 952 8.3e-100 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] 264667412 GU120442.1 190 3.38775e-92 Chrysomela tremulae ribosomal protein L27 (RpL27) mRNA, complete cds K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 O08812 633 3.3e-64 Cationic amino acid transporter 3 OS=Rattus norvegicus GN=Slc7a3 PE=2 SV=1 PF00324//PF13520//PF01777 Amino acid permease//Amino acid permease//Ribosomal L27e protein family GO:0042254//GO:0003333//GO:0006810//GO:0006412//GO:0006865//GO:0055085 ribosome biogenesis//amino acid transmembrane transport//transport//translation//amino acid transport//transmembrane transport GO:0003735//GO:0015171 structural constituent of ribosome//amino acid transmembrane transporter activity GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular -- -- Cluster-8309.377 BP_3 32.00 0.66 2613 662207020 XP_008476992.1 491 2.0e-46 PREDICTED: uncharacterized protein LOC103513915 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02251 Proteasome activator pa28 alpha subunit -- -- -- -- GO:0008537 proteasome activator complex -- -- Cluster-8309.37700 BP_3 148.29 0.58 12569 642934437 XP_008197662.1 5485 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X1 [Tribolium castaneum]>gi|270013709|gb|EFA10157.1| hypothetical protein TcasGA2_TC012345 [Tribolium castaneum] 642934440 XM_008199442.1 78 2.5061e-29 PREDICTED: Tribolium castaneum nucleosome-remodeling factor subunit NURF301 (LOC100141790), transcript variant X3, mRNA K11728 BPTF, E(bx) nucleosome-remodeling factor subunit BPTF http://www.genome.jp/dbget-bin/www_bget?ko:K11728 Q9W0T1 1486 1.6e-162 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00628//PF12125//PF02178 PHD-finger//D domain of beta-TrCP//AT hook motif -- -- GO:0005515//GO:0046983//GO:0003677//GO:0005488 protein binding//protein dimerization activity//DNA binding//binding -- -- KOG1473 Nucleosome remodeling factor, subunit NURF301/BPTF Cluster-8309.37701 BP_3 520.60 6.05 4439 478260090 ENN79875.1 2563 1.8e-286 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 7.00419e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 2116 5.1e-236 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006013//GO:0006000//GO:0006094//GO:0006096//GO:0006098//GO:0006012 mannose metabolic process//fructose metabolic process//gluconeogenesis//glycolytic process//pentose-phosphate shunt//galactose metabolic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.37703 BP_3 64.00 0.67 4879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.37704 BP_3 194.00 3.47 2987 91092022 XP_970951.1 1065 6.2e-113 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 818 1.1e-85 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF03051//PF00112//PF05151 Peptidase C1-like family//Papain family cysteine protease//Photosystem II reaction centre M protein (PsbM) GO:0006508//GO:0015979//GO:0019684 proteolysis//photosynthesis//photosynthesis, light reaction GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity GO:0016021//GO:0009523 integral component of membrane//photosystem II KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37706 BP_3 6836.36 56.95 6078 642917793 XP_008191289.1 2136 8.2e-237 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X3 [Tribolium castaneum] 768412757 XM_011570168.1 425 0 PREDICTED: Plutella xylostella glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1-like (LOC105398114), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q4KMC4 1723 2.6e-190 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Rattus norvegicus GN=Gfpt2 PE=2 SV=3 PF11593//PF01380//PF13580 Mediator complex subunit 3 fungal//SIS domain//SIS domain GO:0006357//GO:0005975 regulation of transcription from RNA polymerase II promoter//carbohydrate metabolic process GO:0030246//GO:0001104 carbohydrate binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.37707 BP_3 172.72 1.71 5160 478256311 ENN76501.1 492 3.0e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37708 BP_3 3902.27 33.37 5928 827549501 XP_012546855.1 643 1.1e-63 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.8e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.37709 BP_3 82.62 1.02 4196 91094331 XP_966352.1 3485 0.0e+00 PREDICTED: ubiquitin-like modifier-activating enzyme 1 [Tribolium castaneum] 242014540 XM_002427901.1 213 7.48377e-105 Pediculus humanus corporis ubiquitin-activating enzyme E1, putative, mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 Q29504 2638 1.4e-296 Ubiquitin-like modifier-activating enzyme 1 OS=Oryctolagus cuniculus GN=UBA1 PE=2 SV=1 PF00899//PF01006//PF00070//PF02170//PF13241 ThiF family//Hepatitis C virus non-structural protein NS4a//Pyridine nucleotide-disulphide oxidoreductase//PAZ domain//Putative NAD(P)-binding GO:0055114//GO:0006779//GO:0019354//GO:0016032 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//viral process GO:0008641//GO:0016491//GO:0005515//GO:0043115 small protein activating enzyme activity//oxidoreductase activity//protein binding//precorrin-2 dehydrogenase activity GO:0019012 virion KOG2012 Ubiquitin activating enzyme UBA1 Cluster-8309.3771 BP_3 81.73 7.35 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37710 BP_3 6653.00 106.92 3291 642917978 XP_008198968.1 593 3.7e-58 PREDICTED: mediator of RNA polymerase II transcription subunit 29 [Tribolium castaneum]>gi|270004684|gb|EFA01132.1| hypothetical protein TcasGA2_TC010345 [Tribolium castaneum] -- -- -- -- -- K15142 MED29 mediator of RNA polymerase II transcription subunit 29 http://www.genome.jp/dbget-bin/www_bget?ko:K15142 Q5ISW3 407 5.6e-38 Mediator of RNA polymerase II transcription subunit 29 OS=Bombyx mori GN=ix PE=2 SV=1 PF11568//PF04179//PF10152//PF10280//PF06624 Mediator complex subunit 29//Initiator tRNA phosphoribosyl transferase//Predicted coiled-coil domain-containing protein (DUF2360)//Mediator complex protein//Ribosome associated membrane protein RAMP4 GO:0006357//GO:0019988 regulation of transcription from RNA polymerase II promoter//charged-tRNA amino acid modification GO:0043399//GO:0001104 tRNA A64-2'-O-ribosylphosphate transferase activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005783//GO:0071203 mediator complex//endoplasmic reticulum//WASH complex KOG3491 Predicted membrane protein Cluster-8309.37711 BP_3 4312.04 21.07 10156 642920909 XP_008192611.1 9151 0.0e+00 PREDICTED: spectrin beta chain isoform X5 [Tribolium castaneum] 642920908 XM_008194389.1 1972 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7742 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00307//PF00435 Calponin homology (CH) domain//Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.37712 BP_3 273.92 2.68 5222 270004497 EFA00945.1 2146 4.9e-238 hypothetical protein TcasGA2_TC003854 [Tribolium castaneum] -- -- -- -- -- K14416 HBS1 elongation factor 1 alpha-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K14416 Q69ZS7 1399 8.3e-153 HBS1-like protein OS=Mus musculus GN=Hbs1l PE=1 SV=2 PF05773//PF01926//PF03144 RWD domain//50S ribosome-binding GTPase//Elongation factor Tu domain 2 -- -- GO:0005525//GO:0005515 GTP binding//protein binding -- -- KOG0458 Elongation factor 1 alpha Cluster-8309.37713 BP_3 18.00 0.36 2707 748995286 AJE75665.1 1586 2.2e-173 putative glycosyl hydrolase [Chrysomela lapponica] 634006820 KF377836.1 35 4.27913e-06 Phyllotreta striolata glycoside hydrolase family 1 (GH1-8) mRNA, complete cds K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1222 1.4e-132 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232//PF00150 Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.37714 BP_3 515.97 34.53 1012 642916834 XP_008199522.1 1552 7.1e-170 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum]>gi|642916836|ref|XP_008199523.1| PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum] 642916839 XM_008201303.1 715 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2B catalytic subunit 2-like (LOC657135), transcript variant X4, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 1378 4.4e-151 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.37716 BP_3 1589.10 26.78 3152 642939230 XP_008194770.1 1711 8.1e-188 PREDICTED: uncharacterized protein LOC656988 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37719 BP_3 2131.92 25.92 4256 91079020 XP_974879.1 2330 1.8e-259 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q5REU4 1468 6.8e-161 Staphylococcal nuclease domain-containing protein 1 OS=Pongo abelii GN=SND1 PE=2 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.37720 BP_3 3980.06 44.85 4569 642935032 XP_008199913.1 2835 0.0e+00 PREDICTED: protein Skeletor, isoforms B/C isoform X2 [Tribolium castaneum]>gi|557470276|gb|AHA05988.1| truncated knickkopf 3 [Tribolium castaneum] 642935031 XM_008201691.1 245 1.32651e-122 PREDICTED: Tribolium castaneum knickkopf 3 (LOC657143), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 2286 1.0e-255 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.37721 BP_3 507.50 12.27 2286 189234241 XP_976116.2 673 1.4e-67 PREDICTED: high affinity copper uptake protein 1 isoform X2 [Tribolium castaneum] 645003520 XM_008214369.1 86 1.60861e-34 PREDICTED: Nasonia vitripennis high affinity copper uptake protein 1 (LOC100122867), transcript variant X2, mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 362 6.4e-33 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145 Ctr copper transporter family GO:0006825//GO:0035434 copper ion transport//copper ion transmembrane transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane KOG3386 Copper transporter Cluster-8309.37722 BP_3 144.61 1.35 5443 546683575 ERL93373.1 1149 2.1e-122 hypothetical protein D910_10665 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37725 BP_3 88.63 1.00 4544 91081645 XP_968283.1 547 1.1e-52 PREDICTED: uncharacterized protein LOC656681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06624 Ribosome associated membrane protein RAMP4 -- -- -- -- GO:0005783 endoplasmic reticulum -- -- Cluster-8309.37726 BP_3 1634.37 25.32 3403 91081645 XP_968283.1 984 1.8e-103 PREDICTED: uncharacterized protein LOC656681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062 Clc-like -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.37728 BP_3 2712.87 20.57 6649 642928597 XP_008199971.1 5998 0.0e+00 PREDICTED: autophagy-related protein 2 homolog A isoform X3 [Tribolium castaneum] -- -- -- -- -- K17906 ATG2 autophagy-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17906 Q80XK6 2306 7.1e-258 Autophagy-related protein 2 homolog B OS=Mus musculus GN=Atg2b PE=1 SV=3 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG2993 Cytoplasm to vacuole targeting protein Cluster-8309.37729 BP_3 187.00 7.64 1471 91076836 XP_974707.1 1517 1.2e-165 PREDICTED: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [Tribolium castaneum]>gi|270001821|gb|EEZ98268.1| hypothetical protein TcasGA2_TC000711 [Tribolium castaneum] 462377192 APGK01023399.1 60 2.9144e-20 Dendroctonus ponderosae Seq01023409, whole genome shotgun sequence K00167 BCKDHB, bkdA2 2-oxoisovalerate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00167 P35738 1276 4.3e-139 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Rattus norvegicus GN=Bckdhb PE=1 SV=3 PF00199//PF02780 Catalase//Transketolase, C-terminal domain GO:0006979//GO:0006804//GO:0008152//GO:0015947//GO:0055114//GO:0006568 response to oxidative stress//obsolete peroxidase reaction//metabolic process//methane metabolic process//oxidation-reduction process//tryptophan metabolic process GO:0003824//GO:0004096//GO:0020037 catalytic activity//catalase activity//heme binding -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.37730 BP_3 76.64 3.04 1505 478257936 ENN78074.1 1572 5.1e-172 hypothetical protein YQE_05228, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7Z2K6 886 7.4e-94 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.37731 BP_3 130.59 6.25 1299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37732 BP_3 172.63 3.94 2406 546675819 ERL86931.1 1426 6.9e-155 hypothetical protein D910_04334, partial [Dendroctonus ponderosae] -- -- -- -- -- K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11147 1044 5.6e-112 Heat shock 70 kDa protein cognate 4 OS=Drosophila melanogaster GN=Hsc70-4 PE=1 SV=3 PF08273//PF01968//PF06723 Zinc-binding domain of primase-helicase//Hydantoinase/oxoprolinase//MreB/Mbl protein GO:0006351//GO:0006269//GO:0000902 transcription, DNA-templated//DNA replication, synthesis of RNA primer//cell morphogenesis GO:0003896//GO:0016787//GO:0004386//GO:0008270 DNA primase activity//hydrolase activity//helicase activity//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.37733 BP_3 579.83 6.40 4661 642926564 XP_008194922.1 3655 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: TBC1 domain family member 1 [Tribolium castaneum] -- -- -- -- -- K17902 TBC1D4, AS160 TBC1 domain family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17902 Q60949 1137 1.8e-122 TBC1 domain family member 1 OS=Mus musculus GN=Tbc1d1 PE=1 SV=3 PF00628//PF00640//PF13851//PF08416 PHD-finger//Phosphotyrosine interaction domain (PTB/PID)//Growth-arrest specific micro-tubule binding//Phosphotyrosine-binding domain GO:0048870 cell motility GO:0005515 protein binding GO:0031514 motile cilium KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.37734 BP_3 1234.62 9.05 6866 642926564 XP_008194922.1 3655 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: TBC1 domain family member 1 [Tribolium castaneum] -- -- -- -- -- K17902 TBC1D4, AS160 TBC1 domain family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17902 Q60949 1137 2.6e-122 TBC1 domain family member 1 OS=Mus musculus GN=Tbc1d1 PE=1 SV=3 PF13851//PF00640//PF08416//PF01022//PF04138//PF00628 Growth-arrest specific micro-tubule binding//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Bacterial regulatory protein, arsR family//GtrA-like protein//PHD-finger GO:0006355//GO:0000271//GO:0048870//GO:0006810 regulation of transcription, DNA-templated//polysaccharide biosynthetic process//cell motility//transport GO:0003700//GO:0005515 transcription factor activity, sequence-specific DNA binding//protein binding GO:0031514//GO:0016021//GO:0005667 motile cilium//integral component of membrane//transcription factor complex KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.37736 BP_3 2002.27 7.74 12761 270007509 EFA03957.1 1887 1.3e-207 hypothetical protein TcasGA2_TC014101 [Tribolium castaneum] 332374221 BT127290.1 481 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 771 1.4e-79 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF02198//PF00642//PF06733//PF01607//PF03176//PF01522 Sterile alpha motif (SAM)/Pointed domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//DEAD_2//Chitin binding Peritrophin-A domain//MMPL family//Polysaccharide deacetylase GO:0006030//GO:0005975//GO:0006807 chitin metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0003677//GO:0005524//GO:0004003//GO:0043565//GO:0046872//GO:0016810//GO:0008061 DNA binding//ATP binding//ATP-dependent DNA helicase activity//sequence-specific DNA binding//metal ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005634//GO:0005657//GO:0016020//GO:0005576 nucleus//replication fork//membrane//extracellular region -- -- Cluster-8309.37738 BP_3 42.72 1.49 1673 659495114 AID66668.1 1065 3.5e-113 short-chain specific acyl-CoA dehydrogenase [Agrotis segetum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q5RAS0 886 8.2e-94 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Pongo abelii GN=ACADS PE=2 SV=1 PF02771//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016627//GO:0050660 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.37739 BP_3 689.16 3.41 10034 91079160 XP_967064.1 4824 0.0e+00 PREDICTED: E3 SUMO-protein ligase RanBP2 [Tribolium castaneum]>gi|270003619|gb|EFA00067.1| hypothetical protein TcasGA2_TC002881 [Tribolium castaneum] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 371 2.6e-33 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF00641//PF00638//PF06810//PF04513 Zn-finger in Ran binding protein and others//RanBP1 domain//Phage minor structural protein GP20//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0046907 intracellular transport GO:0008270//GO:0005198 zinc ion binding//structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.37740 BP_3 217.67 1.66 6605 478255041 ENN75273.1 1173 4.1e-125 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 658861642 XM_008415365.1 133 3.50009e-60 PREDICTED: Poecilia reticulata phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 1058 3.7e-113 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF00520//PF15461//PF01409 Ion transport protein//Beta-carotene 15,15'-dioxygenase//tRNA synthetases class II core domain (F) GO:0055085//GO:0006811//GO:0055114//GO:0043039//GO:0006418 transmembrane transport//ion transport//oxidation-reduction process//tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0000049//GO:0016702//GO:0005524//GO:0004812//GO:0005216 tRNA binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//ATP binding//aminoacyl-tRNA ligase activity//ion channel activity GO:0005737//GO:0016020 cytoplasm//membrane KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.37741 BP_3 843.19 6.06 7001 332376114 AEE63197.1 1491 5.8e-162 unknown [Dendroctonus ponderosae] 332376113 BT128237.1 195 1.27026e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 954 4.5e-101 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF00412//PF13180//PF08782//PF05493 PDZ domain (Also known as DHR or GLGF)//LIM domain//PDZ domain//c-SKI Smad4 binding domain//ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078//GO:0008270//GO:0005515//GO:0046332 hydrogen ion transmembrane transporter activity//zinc ion binding//protein binding//SMAD binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.37743 BP_3 8373.17 1515.21 558 91076454 XP_971838.1 459 2.2e-43 PREDICTED: ubiquitin-like protein FUBI [Tribolium castaneum]>gi|270002576|gb|EEZ99023.1| hypothetical protein TcasGA2_TC004892 [Tribolium castaneum] -- -- -- -- -- K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 P0C2F0 185 5.2e-13 40S ribosomal protein S30 OS=Pongo abelii GN=FAU PE=3 SV=1 PF00240//PF04758 Ubiquitin family//Ribosomal protein S30 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG0009 Ubiquitin-like/40S ribosomal S30 protein fusion Cluster-8309.37746 BP_3 26.00 9.85 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37748 BP_3 143.73 11.35 902 642928915 XP_008195614.1 189 7.1e-12 PREDICTED: FK506-binding protein 5 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37750 BP_3 41.54 0.45 4733 270002885 EEZ99332.1 703 9.3e-71 serine protease P46 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75096 311 1.1e-26 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF03875//PF00057//PF07415//PF00089 Statherin//Low-density lipoprotein receptor domain class A//Gammaherpesvirus latent membrane protein (LMP2) protein//Trypsin GO:0042742//GO:0030500//GO:0019042//GO:0006508 defense response to bacterium//regulation of bone mineralization//viral latency//proteolysis GO:0005515//GO:0046848//GO:0004252 protein binding//hydroxyapatite binding//serine-type endopeptidase activity GO:0033644//GO:0005576 host cell membrane//extracellular region KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.37751 BP_3 416.81 9.82 2338 91091932 XP_966409.1 3387 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 808130532 XM_012312605.1 158 1.55521e-74 PREDICTED: Bombus terrestris structural maintenance of chromosomes protein 3 (LOC100648683), transcript variant X3, mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 Q5R4K5 1981 1.2e-220 Structural maintenance of chromosomes protein 3 OS=Pongo abelii GN=SMC3 PE=2 SV=1 PF04111//PF13304//PF06470//PF00005//PF01580 Autophagy protein Apg6//AAA domain, putative AbiEii toxin, Type IV TA system//SMC proteins Flexible Hinge Domain//ABC transporter//FtsK/SpoIIIE family GO:0006914//GO:0006281//GO:0051276//GO:0030261//GO:0006310//GO:0007062 autophagy//DNA repair//chromosome organization//chromosome condensation//DNA recombination//sister chromatid cohesion GO:0005515//GO:0005524//GO:0003677//GO:0000166//GO:0016887 protein binding//ATP binding//DNA binding//nucleotide binding//ATPase activity GO:0005634//GO:0005694 nucleus//chromosome KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.37752 BP_3 56.47 0.82 3627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37754 BP_3 18.99 0.40 2555 546685861 ERL95293.1 2122 1.4e-235 hypothetical protein D910_12559, partial [Dendroctonus ponderosae] 642919307 XM_008193597.1 101 8.26078e-43 PREDICTED: Tribolium castaneum signal-induced proliferation-associated 1-like protein 2 (LOC660473), transcript variant X2, mRNA K17702 SIPA1L2, SPAL2 signal-induced proliferation-associated 1 like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17702 Q5JCS6 703 2.1e-72 Signal-induced proliferation-associated 1-like protein 2 OS=Rattus norvegicus GN=Sipa1l2 PE=2 SV=1 PF02145 Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.37757 BP_3 23.82 0.43 2986 734641965 XP_010749894.1 426 7.8e-39 PREDICTED: zinc finger protein 135-like [Larimichthys crocea] -- -- -- -- -- -- -- -- -- Q6ZMW2 404 1.1e-37 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF13465//PF16622//PF01363 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.37758 BP_3 61.56 0.76 4194 478254062 ENN74354.1 272 7.9e-21 hypothetical protein YQE_09324, partial [Dendroctonus ponderosae]>gi|546672807|gb|ERL84563.1| hypothetical protein D910_01992 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37760 BP_3 2421.24 70.55 1946 -- -- -- -- -- 675805952 KM271780.1 175 4.57623e-84 Naupactus xanthographus isolate Nx6 clone 3 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37761 BP_3 13481.00 454.94 1720 332375446 AEE62864.1 1672 1.5e-183 unknown [Dendroctonus ponderosae] 332375445 BT127902.1 381 0 Dendroctonus ponderosae clone DPO115_B09 unknown mRNA K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P07764 1384 1.5e-151 Fructose-bisphosphate aldolase OS=Drosophila melanogaster GN=Ald PE=1 SV=5 PF00274 Fructose-bisphosphate aldolase class-I GO:0006000//GO:0006013//GO:0015976//GO:0006094//GO:0006020//GO:0006098//GO:0006096 fructose metabolic process//mannose metabolic process//carbon utilization//gluconeogenesis//inositol metabolic process//pentose-phosphate shunt//glycolytic process GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8309.37762 BP_3 35.00 1.24 1654 642938321 XP_008192847.1 1878 1.8e-207 PREDICTED: argininosuccinate lyase [Tribolium castaneum] -- -- -- -- -- K01755 argH, ASL argininosuccinate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01755 P51464 1470 1.5e-161 Argininosuccinate lyase OS=Lithobates catesbeiana GN=ASL PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1316 Argininosuccinate lyase Cluster-8309.37763 BP_3 458.26 23.29 1240 478250378 ENN70873.1 1152 2.1e-123 hypothetical protein YQE_12278, partial [Dendroctonus ponderosae]>gi|546672870|gb|ERL84593.1| hypothetical protein D910_02021 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 545 2.1e-54 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.37764 BP_3 1457.28 59.61 1470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.37765 BP_3 22.40 0.72 1792 332374576 AEE62429.1 1105 8.6e-118 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 272 5.03519e-138 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 987 1.7e-105 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- KOG0819 Annexin Cluster-8309.37766 BP_3 2172.68 51.73 2316 332374576 AEE62429.1 1472 3.1e-160 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 295 1.07088e-150 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1258 8.3e-137 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding -- -- -- -- Cluster-8309.37767 BP_3 1671.70 22.24 3914 91089461 XP_968383.1 1941 2.2e-214 PREDICTED: fatty-acid amide hydrolase 2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6GMR7 1103 1.3e-118 Fatty-acid amide hydrolase 2 OS=Homo sapiens GN=FAAH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.37769 BP_3 64.98 0.73 4574 270013465 EFA09913.1 1341 9.4e-145 hypothetical protein TcasGA2_TC012064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02663 568 1.7e-56 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.37771 BP_3 8256.61 63.57 6552 642918534 XP_008191512.1 5436 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 2920 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF16656//PF13895//PF00041//PF16794//PF14604//PF00018 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain//Fibronectin-III type domain//Variant SH3 domain//SH3 domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.37772 BP_3 1416.40 37.16 2129 817089825 XP_012267798.1 326 2.2e-27 PREDICTED: V-type proton ATPase 16 kDa proteolipid subunit [Athalia rosae] 594071842 XM_006059709.1 78 4.19012e-30 PREDICTED: Bubalus bubalis ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (ATP6V0C), mRNA K02155 ATPeV0C, ATP6L V-type H+-transporting ATPase 16kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02155 O16110 319 5.8e-28 V-type proton ATPase 16 kDa proteolipid subunit OS=Aedes aegypti GN=AAEL000291 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0232 Vacuolar H+-ATPase V0 sector, subunits c/c' Cluster-8309.37773 BP_3 923.81 39.75 1412 189238112 XP_001814047.1 1410 2.9e-153 PREDICTED: bleomycin hydrolase [Tribolium castaneum]>gi|270008738|gb|EFA05186.1| hypothetical protein TcasGA2_TC015316 [Tribolium castaneum] 158302192 XM_321804.4 224 1.90209e-111 Anopheles gambiae str. PEST AGAP001341-PA (AgaP_AGAP001341) mRNA, complete cds K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 P70645 1059 6.0e-114 Bleomycin hydrolase OS=Rattus norvegicus GN=Blmh PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG4128 Bleomycin hydrolases and aminopeptidases of cysteine protease family Cluster-8309.37774 BP_3 20896.00 839.12 1492 389608293 BAM17758.1 809 1.5e-83 elongation factor 1 gamma [Papilio xuthus] 157128963 XM_001661520.1 204 2.64056e-100 Aedes aegypti AAEL011288-RA mRNA K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 Q9NJH0 760 3.0e-79 Elongation factor 1-gamma OS=Drosophila melanogaster GN=Ef1gamma PE=2 SV=2 PF00739//PF12519//PF00647//PF01239//PF10596 Trans-activation protein X//Mitochondrial distribution and morphology protein 10//Elongation factor 1 gamma, conserved domain//Protein prenyltransferase alpha subunit repeat//U6-snRNA interacting domain of PrP8 GO:0006414//GO:0019079//GO:0018342//GO:0006448//GO:0007005 translational elongation//viral genome replication//protein prenylation//regulation of translational elongation//mitochondrion organization GO:0017070//GO:0008318//GO:0003746 U6 snRNA binding//protein prenyltransferase activity//translation elongation factor activity GO:0032865//GO:0005840 ERMES complex//ribosome KOG1627 Translation elongation factor EF-1 gamma Cluster-8309.37775 BP_3 10161.76 195.97 2791 332373526 AEE61904.1 1352 3.1e-146 unknown [Dendroctonus ponderosae]>gi|478254046|gb|ENN74338.1| hypothetical protein YQE_09308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBX0 704 1.7e-72 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF03435//PF01370//PF00106 Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0050662//GO:0003824 oxidoreductase activity//coenzyme binding//catalytic activity -- -- KOG2733 Uncharacterized membrane protein Cluster-8309.37776 BP_3 27.49 0.68 2251 546681841 ERL91856.1 1742 1.5e-191 hypothetical protein D910_09181 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q15582 494 3.1e-48 Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens GN=TGFBI PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.37777 BP_3 7456.89 99.61 3900 91089945 XP_973312.1 3473 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit A [Tribolium castaneum]>gi|270013675|gb|EFA10123.1| hypothetical protein TcasGA2_TC012303 [Tribolium castaneum] -- -- -- -- -- K03254 EIF3A translation initiation factor 3 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03254 Q173M7 2783 0.0e+00 Eukaryotic translation initiation factor 3 subunit A OS=Aedes aegypti GN=eIF3-S10 PE=3 SV=1 PF01399//PF02983 PCI domain//Alpha-lytic protease prodomain GO:0006413//GO:0006508//GO:0006446 translational initiation//proteolysis//regulation of translational initiation GO:0008236//GO:0003743//GO:0005515 serine-type peptidase activity//translation initiation factor activity//protein binding GO:0005840//GO:0005576 ribosome//extracellular region KOG2072 Translation initiation factor 3, subunit a (eIF-3a) Cluster-8309.3778 BP_3 5.63 0.47 867 642912538 XP_008200905.1 286 3.9e-23 PREDICTED: uncharacterized protein LOC103315037 [Tribolium castaneum]>gi|270002598|gb|EEZ99045.1| hypothetical protein TcasGA2_TC004919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37780 BP_3 166.23 1.13 7380 189237751 XP_001812575.1 3801 0.0e+00 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 1.1e-81 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF08070//PF00787//PF04769 DTHCT (NUC029) region//PX domain//Mating-type protein MAT alpha 1 HMG-box GO:0007531//GO:0006265//GO:0045895 mating type determination//DNA topological change//positive regulation of mating-type specific transcription, DNA-templated GO:0035091//GO:0003677//GO:0005524//GO:0008301//GO:0003918 phosphatidylinositol binding//DNA binding//ATP binding//DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.37781 BP_3 385.86 2.05 9349 86515360 NP_001034507.1 1537 3.6e-167 dorsal [Tribolium castaneum]>gi|11496169|gb|AAG22858.1| Dorsal [Tribolium castaneum] 462460645 APGK01006274.1 58 2.4432e-18 Dendroctonus ponderosae Seq01006279, whole genome shotgun sequence K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 1100 7.0e-118 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF08050//PF10415//PF02894//PF01408//PF00554 Tetracycline resistance leader peptide//Fumarase C C-terminus//Oxidoreductase family, C-terminal alpha/beta domain//Oxidoreductase family, NAD-binding Rossmann fold//Rel homology DNA-binding domain GO:0006099//GO:0006355//GO:0046677//GO:0055114//GO:0008152 tricarboxylic acid cycle//regulation of transcription, DNA-templated//response to antibiotic//oxidation-reduction process//metabolic process GO:0016829//GO:0003700//GO:0003677//GO:0016491 lyase activity//transcription factor activity, sequence-specific DNA binding//DNA binding//oxidoreductase activity GO:0005667 transcription factor complex -- -- Cluster-8309.37783 BP_3 558.00 10.28 2908 642936145 XP_008198316.1 2403 4.3e-268 PREDICTED: protein TRC8 homolog [Tribolium castaneum]>gi|270014053|gb|EFA10501.1| hypothetical protein TcasGA2_TC012749 [Tribolium castaneum] 442621694 NM_001276141.1 123 5.54544e-55 Drosophila melanogaster Trc8 (Trc8), transcript variant E, mRNA K15703 RNF139, TRC8 E3 ubiquitin-protein ligase RNF139 http://www.genome.jp/dbget-bin/www_bget?ko:K15703 Q7KRW1 1573 3.1e-173 Protein TRC8 homolog OS=Drosophila melanogaster GN=Trc8 PE=1 SV=1 PF00097//PF14634//PF12906//PF17123//PF12678//PF12861//PF03854//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//P-11 zinc finger//Ring finger domain GO:0016567 protein ubiquitination GO:0005515//GO:0046872//GO:0004842//GO:0008270//GO:0003723 protein binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding//RNA binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.37784 BP_3 12.66 41.76 277 91088863 XP_971818.1 143 4.7e-07 PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932389|ref|XP_008197091.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932391|ref|XP_008197092.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|270011591|gb|EFA08039.1| hypothetical protein TcasGA2_TC005632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37786 BP_3 1188.45 11.78 5156 642935312 XP_008197963.1 2087 3.3e-231 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 1.04617e-14 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1142 5.2e-123 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF08702//PF00038//PF10186 Fibrinogen alpha/beta chain family//Intermediate filament protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0007165//GO:0051258//GO:0030168//GO:0010508 signal transduction//protein polymerization//platelet activation//positive regulation of autophagy GO:0005198//GO:0005102//GO:0030674 structural molecule activity//receptor binding//protein binding, bridging GO:0005882//GO:0005577 intermediate filament//fibrinogen complex -- -- Cluster-8309.37790 BP_3 3.00 0.44 624 15809016 NP_291024.1 619 6.8e-62 myosin regulatory light chain 12B [Homo sapiens]>gi|21728376|ref|NP_075891.1| myosin regulatory light chain 12B [Mus musculus]>gi|203097095|ref|NP_059039.2| myosin regulatory light chain 12B [Rattus norvegicus]>gi|222144324|ref|NP_001138416.1| myosin regulatory light chain 12B [Homo sapiens]>gi|222144326|ref|NP_001138417.1| myosin regulatory light chain 12B [Homo sapiens]>gi|388454830|ref|NP_001252888.1| myosin regulatory light chain 12B [Macaca mulatta]>gi|126321805|ref|XP_001364033.1| PREDICTED: myosin regulatory light chain 12B isoform X1 [Monodelphis domestica]>gi|291394149|ref|XP_002713645.1| PREDICTED: myosin regulatory light chain 12B [Oryctolagus cuniculus]>gi|296222306|ref|XP_002757131.1| PREDICTED: myosin regulatory light chain 12B [Callithrix jacchus]>gi|297702299|ref|XP_002828122.1| PREDICTED: myosin regulatory light chain 12B [Pongo abelii]>gi|311259003|ref|XP_003127889.1| PREDICTED: myosin regulatory light chain 12B isoform 1 [Sus scrofa]>gi|332225807|ref|XP_003262075.1| PREDICTED: myosin regulatory light chain 12B [Nomascus leucogenys]>gi|332225811|ref|XP_003262077.1| PREDICTED: myosin regulatory light chain 12B [Nomascus leucogenys]>gi|332225813|ref|XP_003262078.1| PREDICTED: myosin regulatory light chain 12B [Nomascus leucogenys]>gi|332849582|ref|XP_001145151.2| PREDICTED: myosin regulatory light chain 12B [Pan troglodytes]>gi|344269151|ref|XP_003406418.1| PREDICTED: myosin regulatory light chain 12B [Loxodonta africana]>gi|348557406|ref|XP_003464510.1| PREDICTED: myosin regulatory light chain 12B [Cavia porcellus]>gi|354499681|ref|XP_003511936.1| PREDICTED: myosin regulatory light chain 12B [Cricetulus griseus]>gi|395511670|ref|XP_003760078.1| PREDICTED: myosin regulatory light chain 12B [Sarcophilus harrisii]>gi|397494126|ref|XP_003817939.1| PREDICTED: myosin regulatory light chain 12B [Pan paniscus]>gi|402902717|ref|XP_003914243.1| PREDICTED: myosin regulatory light chain 12B [Papio anubis]>gi|426385348|ref|XP_004059180.1| PREDICTED: myosin regulatory light chain 12B isoform 1 [Gorilla gorilla gorilla]>gi|426385350|ref|XP_004059181.1| PREDICTED: myosin regulatory light chain 12B isoform 2 [Gorilla gorilla gorilla]>gi|426385352|ref|XP_004059182.1| PREDICTED: myosin regulatory light chain 12B isoform 3 [Gorilla gorilla gorilla]>gi|426385354|ref|XP_004059183.1| PREDICTED: myosin regulatory light chain 12B isoform 4 [Gorilla gorilla gorilla]>gi|426385356|ref|XP_004059184.1| PREDICTED: myosin regulatory light chain 12B isoform 5 [Gorilla gorilla gorilla]>gi|441603272|ref|XP_004087793.1| PREDICTED: myosin regulatory light chain 12B [Nomascus leucogenys]>gi|488569687|ref|XP_004474455.1| PREDICTED: myosin regulatory light chain 12B [Dasypus novemcinctus]>gi|507557940|ref|XP_004662709.1| PREDICTED: myosin regulatory light chain 12B isoform X1 [Jaculus jaculus]>gi|512982517|ref|XP_004853248.1| PREDICTED: myosin regulatory light chain 12B isoform X1 [Heterocephalus glaber]>gi|512982519|ref|XP_004853249.1| PREDICTED: myosin regulatory light chain 12B isoform X1 [Heterocephalus glaber]>gi|532049689|ref|XP_005367613.1| PREDICTED: myosin regulatory light chain 12B isoform X1 [Microtus ochrogaster]>gi|532049691|ref|XP_005367614.1| PREDICTED: myosin regulatory light chain 12B isoform X2 [Microtus ochrogaster]>gi|532103138|ref|XP_005337172.1| PREDICTED: myosin regulatory light chain 12B [Ictidomys tridecemlineatus]>gi|554548527|ref|XP_005868803.1| PREDICTED: myosin regulatory light chain 12B [Myotis brandtii]>gi|558127275|ref|XP_006089321.1| PREDICTED: myosin regulatory light chain 12B [Myotis lucifugus]>gi|560965599|ref|XP_006205195.1| PREDICTED: myosin regulatory light chain 12B isoform X1 [Vicugna pacos]>gi|562834370|ref|XP_006146551.1| PREDICTED: myosin regulatory light chain 12B-like [Tupaia chinensis]>gi|584084318|ref|XP_006761922.1| PREDICTED: myosin regulatory light chain 12B [Myotis davidii]>gi|586530419|ref|XP_006920120.1| PREDICTED: myosin regulatory light chain 12B [Pteropus alecto]>gi|589918028|ref|XP_006972320.1| PREDICTED: myosin regulatory light chain 12B [Peromyscus maniculatus bairdii]>gi|591327196|ref|XP_007089550.1| PREDICTED: myosin regulatory light chain 12B [Panthera tigris altaica]>gi|617588315|ref|XP_007519928.1| PREDICTED: myosin regulatory light chain 12B isoform X1 [Erinaceus europaeus]>gi|625279862|ref|XP_007631570.1| PREDICTED: myosin regulatory light chain 12B [Cricetulus griseus]>gi|635099817|ref|XP_007972722.1| PREDICTED: myosin regulatory light chain 12B [Chlorocebus sabaeus]>gi|640834466|ref|XP_008072948.1| PREDICTED: myosin regulatory light chain 12B [Tarsius syrichta]>gi|655835960|ref|XP_008259338.1| PREDICTED: myosin regulatory light chain 12B [Oryctolagus cuniculus]>gi|667293277|ref|XP_008578507.1| PREDICTED: myosin regulatory light chain 12B [Galeopterus variegatus]>gi|674053025|ref|XP_008832841.1| PREDICTED: myosin regulatory light chain 12B [Nannospalax galili]>gi|674053027|ref|XP_008832842.1| PREDICTED: myosin regulatory light chain 12B [Nannospalax galili]>gi|674053029|ref|XP_008832843.1| PREDICTED: myosin regulatory light chain 12B [Nannospalax galili]>gi|675715813|ref|XP_008977810.1| PREDICTED: myosin regulatory light chain 12B [Callithrix jacchus]>gi|686755509|ref|XP_009250546.1| PREDICTED: myosin regulatory light chain 12B [Pongo abelii]>gi|724950982|ref|XP_010351500.1| PREDICTED: myosin regulatory light chain 12B [Rhinopithecus roxellana]>gi|743724873|ref|XP_010956383.1| PREDICTED: myosin regulatory light chain 12B [Camelus bactrianus]>gi|744538758|ref|XP_010974744.1| PREDICTED: myosin regulatory light chain 12B [Camelus dromedarius]>gi|755781617|ref|XP_011286390.1| PREDICTED: myosin regulatory light chain 12B [Felis catus]>gi|759177242|ref|XP_011378036.1| PREDICTED: myosin regulatory light chain 12B [Pteropus vampyrus]>gi|795230974|ref|XP_011851718.1| PREDICTED: myosin regulatory light chain 12B [Mandrillus leucophaeus]>gi|795230981|ref|XP_011851719.1| PREDICTED: myosin regulatory light chain 12B [Mandrillus leucophaeus]>gi|795230988|ref|XP_011851720.1| PREDICTED: myosin regulatory light chain 12B [Mandrillus leucophaeus]>gi|795277088|ref|XP_011813184.1| PREDICTED: myosin regulatory light chain 12B [Colobus angolensis palliatus]>gi|795277096|ref|XP_011813185.1| PREDICTED: myosin regulatory light chain 12B [Colobus angolensis palliatus]>gi|795277104|ref|XP_011813186.1| PREDICTED: myosin regulatory light chain 12B [Colobus angolensis palliatus]>gi|795277110|ref|XP_011813187.1| PREDICTED: myosin regulatory light chain 12B [Colobus angolensis palliatus]>gi|795578574|ref|XP_011911608.1| PREDICTED: myosin regulatory light chain 12B [Cercocebus atys]>gi|821132049|ref|XP_012373424.1| PREDICTED: myosin regulatory light chain 12B [Dasypus novemcinctus]>gi|826315816|ref|XP_012507567.1| PREDICTED: myosin regulatory light chain 12B [Propithecus coquereli]>gi|829958494|ref|XP_012601550.1| PREDICTED: myosin regulatory light chain 12B [Microcebus murinus]>gi|829958497|ref|XP_012601552.1| PREDICTED: myosin regulatory light chain 12B [Microcebus murinus]>gi|852780956|ref|XP_012882637.1| PREDICTED: myosin regulatory light chain 12B [Dipodomys ordii]>gi|145566796|sp|Q3THE2.2|ML12B_MOUSE RecName: Full=Myosin regulatory light chain 12B; AltName: Full=Myosin regulatory light chain 2-B, smooth muscle isoform; AltName: Full=Myosin regulatory light chain 20 kDa; Short=MLC20; AltName: Full=Myosin regulatory light chain MRLC2>gi|205829213|sp|O14950.2|ML12B_HUMAN RecName: Full=Myosin regulatory light chain 12B; AltName: Full=MLC-2A; Short=MLC-2; AltName: Full=Myosin regulatory light chain 2-B, smooth muscle isoform; AltName: Full=Myosin regulatory light chain 20 kDa; Short=MLC20; AltName: Full=Myosin regulatory light chain MRLC2; AltName: Full=SHUJUN-1>gi|2119365|pir||S45709 myosin regulatory light chain 2, brain (clone FY53) - rat>gi|829623|gb|AAA67367.1| myosin regulatory light chain [Homo sapiens]>gi|12833199|dbj|BAB22432.1| unnamed protein product [Mus musculus]>gi|12836845|dbj|BAB23832.1| unnamed protein product [Mus musculus]>gi|13436446|gb|AAH04994.1| Myosin, light chain 12B, regulatory [Homo sapiens]>gi|15076511|dbj|BAB62403.1| nonmuscle myosin light chain 2 [Homo sapiens]>gi|20135922|dbj|BAB88918.1| myosin regulatory light chain [Homo sapiens]>gi|22137716|gb|AAH28878.1| Myosin light chain, regulatory B [Mus musculus]>gi|38014565|gb|AAH60577.1| Mrlc2 protein [Rattus norvegicus]>gi|71051212|gb|AAH99425.1| Myosin light chain, regulatory B [Mus musculus]>gi|74222204|dbj|BAE26912.1| unnamed protein product [Mus musculus]>gi|119622080|gb|EAX01675.1| myosin regulatory light chain MRLC2, isoform CRA_a [Homo sapiens]>gi|119622081|gb|EAX01676.1| myosin regulatory light chain MRLC2, isoform CRA_a [Homo sapiens]>gi|119622082|gb|EAX01677.1| myosin regulatory light chain MRLC2, isoform CRA_a [Homo sapiens]>gi|124297781|gb|AAI31926.1| Myosin light chain, regulatory B [Mus musculus]>gi|124298040|gb|AAI31928.1| Myosin light chain, regulatory B [Mus musculus]>gi|148706423|gb|EDL38370.1| mCG5403 [Mus musculus]>gi|149036285|gb|EDL90944.1| rCG35658, isoform CRA_a [Rattus norvegicus]>gi|149036286|gb|EDL90945.1| rCG35658, isoform CRA_a [Rattus norvegicus]>gi|158256884|dbj|BAF84415.1| unnamed protein product [Homo sapiens]>gi|344238084|gb|EGV94187.1| Myosin regulatory light chain 12B [Cricetulus griseus]>gi|351715773|gb|EHB18692.1| Myosin regulatory light chain 12B [Heterocephalus glaber]>gi|355701838|gb|EHH29191.1| Myosin regulatory light chain MRLC2 [Macaca mulatta]>gi|431896313|gb|ELK05729.1| Myosin regulatory light chain 12B [Pteropus alecto]>gi|432105411|gb|ELK31626.1| Myosin regulatory light chain 12B [Myotis davidii]>gi|444727214|gb|ELW67717.1| Myosin regulatory light chain 12B [Tupaia chinensis]>gi|521027488|gb|EPQ09276.1| Myosin regulatory light chain 12B [Myotis brandtii]>gi|649113523|gb|AIC52812.1| MYL12B, partial [synthetic construct] 15076510 AB046614.1 615 0 Homo sapiens MLC-2 mRNA for nonmuscle myosin light chain 2, complete cds K12757 MYL12 myosin regulatory light chain 12 http://www.genome.jp/dbget-bin/www_bget?ko:K12757 O14950 619 2.8e-63 Myosin regulatory light chain 12B OS=Homo sapiens GN=MYL12B PE=1 SV=2 PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair GO:0008360//GO:0006936//GO:0007411 regulation of cell shape//muscle contraction//axon guidance GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0001725//GO:0030018//GO:0016460//GO:0045177//GO:0005829 stress fiber//Z disc//myosin II complex//apical part of cell//cytosol KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.37791 BP_3 572.77 7.53 3957 478254003 ENN74295.1 1276 2.8e-137 hypothetical protein YQE_09267, partial [Dendroctonus ponderosae]>gi|546673725|gb|ERL85281.1| hypothetical protein D910_02702 [Dendroctonus ponderosae] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 P13280 850 2.9e-89 Glycogenin-1 OS=Oryctolagus cuniculus GN=GYG1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.37795 BP_3 2845.76 81.83 1968 642910476 XP_008200230.1 1273 3.1e-137 PREDICTED: hrp65 protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K13219 SFPQ, PSF splicing factor, proline- and glutamine-rich http://www.genome.jp/dbget-bin/www_bget?ko:K13219 Q9U1N0 986 2.4e-105 Hrp65 protein OS=Chironomus tentans GN=HRP65 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0115 RNA-binding protein p54nrb (RRM superfamily) Cluster-8309.37796 BP_3 512.77 2.85 8974 817065912 XP_012254772.1 7951 0.0e+00 PREDICTED: translational activator GCN1 [Athalia rosae] 820859669 XM_003697079.2 471 0 PREDICTED: Apis florea translational activator GCN1 (LOC100865997), mRNA -- -- -- -- Q92616 5791 0.0e+00 Translational activator GCN1 OS=Homo sapiens GN=GCN1L1 PE=1 SV=6 PF01602//PF00042//PF00125//PF02269//PF02985//PF08064 Adaptin N terminal region//Globin//Core histone H2A/H2B/H3/H4//Transcription initiation factor IID, 18kD subunit//HEAT repeat//UME (NUC010) domain GO:0009069//GO:0006886//GO:0016310//GO:0016192//GO:0006366 serine family amino acid metabolic process//intracellular protein transport//phosphorylation//vesicle-mediated transport//transcription from RNA polymerase II promoter GO:0020037//GO:0004674//GO:0003677//GO:0019825//GO:0005515 heme binding//protein serine/threonine kinase activity//DNA binding//oxygen binding//protein binding GO:0030117 membrane coat KOG1242 Protein containing adaptin N-terminal region Cluster-8309.37797 BP_3 2797.87 115.93 1455 91079304 XP_966317.1 1568 1.4e-171 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 647 3.7e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.37798 BP_3 163.81 0.87 9374 570341960 AHE77377.1 2740 1.2e-306 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 905 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2669 8.1e-300 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF01968//PF01370//PF02491//PF01194//PF00033//PF04625//PF06723//PF01223//PF05739//PF00106//PF01073//PF08303//PF02782 Hydantoinase/oxoprolinase//NAD dependent epimerase/dehydratase family//SHS2 domain inserted in FTSA//RNA polymerases N / 8 kDa subunit//Cytochrome b/b6/petB//DEC-1 protein, N-terminal region//MreB/Mbl protein//DNA/RNA non-specific endonuclease//SNARE domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//tRNA ligase kinase domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0006388//GO:0022904//GO:0008152//GO:0008210//GO:0055114//GO:0005975//GO:0008207//GO:0000902//GO:0006144//GO:0006351//GO:0006206//GO:0008209//GO:0006694//GO:0007304//GO:0007049 tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain//metabolic process//estrogen metabolic process//oxidation-reduction process//carbohydrate metabolic process//C21-steroid hormone metabolic process//cell morphogenesis//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//androgen metabolic process//steroid biosynthetic process//chorion-containing eggshell formation//cell cycle GO:0016491//GO:0046872//GO:0016773//GO:0003676//GO:0016616//GO:0005524//GO:0003854//GO:0005515//GO:0003824//GO:0003677//GO:0003972//GO:0050662//GO:0005213//GO:0003899//GO:0016787 oxidoreductase activity//metal ion binding//phosphotransferase activity, alcohol group as acceptor//nucleic acid binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//ATP binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//protein binding//catalytic activity//DNA binding//RNA ligase (ATP) activity//coenzyme binding//structural constituent of chorion//DNA-directed RNA polymerase activity//hydrolase activity GO:0005730//GO:0005576//GO:0016020//GO:0042600 nucleolus//extracellular region//membrane//chorion KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.378 BP_3 17.00 1.00 1115 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37800 BP_3 721.24 39.14 1180 478259299 ENN79201.1 662 1.3e-66 hypothetical protein YQE_04385, partial [Dendroctonus ponderosae]>gi|546681741|gb|ERL91773.1| hypothetical protein D910_09099 [Dendroctonus ponderosae] -- -- -- -- -- K05770 BZRP benzodiazapine receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05770 P16257 416 1.8e-39 Translocator protein OS=Rattus norvegicus GN=Tspo PE=1 SV=1 PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane KOG3797 Peripheral-type benzodiazepine receptor and related proteins Cluster-8309.37802 BP_3 1366.65 8.16 8367 91077082 XP_969760.1 2971 0.0e+00 PREDICTED: protein NRDE2 homolog [Tribolium castaneum]>gi|270002034|gb|EEZ98481.1| hypothetical protein TcasGA2_TC000974 [Tribolium castaneum] 742984403 CP010377.1 47 2.84726e-12 Enterobacter cloacae strain 34983, complete genome K03639 MOCS1, moaA cyclic pyranopterin phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K03639 Q8IQF1 1535 2.3e-168 Molybdenum cofactor biosynthesis protein 1 OS=Drosophila melanogaster GN=Mocs1 PE=2 SV=1 PF01967//PF15015//PF06463//PF00057//PF04055//PF05373 MoaC family//Spermatogenesis-associated, N-terminal//Molybdenum Cofactor Synthesis C//Low-density lipoprotein receptor domain class A//Radical SAM superfamily//L-proline 3-hydroxylase, C-terminal GO:0006777//GO:0007283//GO:0055114 Mo-molybdopterin cofactor biosynthetic process//spermatogenesis//oxidation-reduction process GO:0003824//GO:0005515//GO:0016706//GO:0051536//GO:0051539 catalytic activity//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron-sulfur cluster binding//4 iron, 4 sulfur cluster binding GO:0005794//GO:0019008 Golgi apparatus//molybdopterin synthase complex KOG2876 Molybdenum cofactor biosynthesis pathway protein Cluster-8309.37803 BP_3 206.45 1.82 5756 642921963 XP_008192963.1 2834 0.0e+00 PREDICTED: uncharacterized protein LOC658725 [Tribolium castaneum]>gi|270007382|gb|EFA03830.1| hypothetical protein TcasGA2_TC013946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.37804 BP_3 101.82 1.28 4111 642922741 XP_008193305.1 3310 0.0e+00 PREDICTED: dynamin-1-like protein isoform X1 [Tribolium castaneum]>gi|270007540|gb|EFA03988.1| hypothetical protein TcasGA2_TC014137 [Tribolium castaneum] 642922742 XM_001815078.2 425 0 PREDICTED: Tribolium castaneum dynamin-1-like protein (LOC660635), transcript variant X2, mRNA K17065 DNM1L dynamin 1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17065 O00429 2324 3.6e-260 Dynamin-1-like protein OS=Homo sapiens GN=DNM1L PE=1 SV=2 PF01926//PF01031//PF02212 50S ribosome-binding GTPase//Dynamin central region//Dynamin GTPase effector domain GO:0006184 obsolete GTP catabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.37805 BP_3 87.30 0.96 4658 642922741 XP_008193305.1 2492 3.3e-278 PREDICTED: dynamin-1-like protein isoform X1 [Tribolium castaneum]>gi|270007540|gb|EFA03988.1| hypothetical protein TcasGA2_TC014137 [Tribolium castaneum] 642922742 XM_001815078.2 425 0 PREDICTED: Tribolium castaneum dynamin-1-like protein (LOC660635), transcript variant X2, mRNA K17065 DNM1L dynamin 1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17065 O00429 1988 3.7e-221 Dynamin-1-like protein OS=Homo sapiens GN=DNM1L PE=1 SV=2 PF07355//PF01926//PF01031//PF02212 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)//50S ribosome-binding GTPase//Dynamin central region//Dynamin GTPase effector domain GO:0055114//GO:0006184 oxidation-reduction process//obsolete GTP catabolic process GO:0003924//GO:0050485//GO:0005525 GTPase activity//oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.37806 BP_3 826.88 10.77 3991 189237265 XP_001815130.1 3218 0.0e+00 PREDICTED: dynamin-1-like protein isoform X2 [Tribolium castaneum] 642922742 XM_001815078.2 425 0 PREDICTED: Tribolium castaneum dynamin-1-like protein (LOC660635), transcript variant X2, mRNA K17065 DNM1L dynamin 1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17065 O00429 2343 2.2e-262 Dynamin-1-like protein OS=Homo sapiens GN=DNM1L PE=1 SV=2 PF01031//PF01926//PF02212 Dynamin central region//50S ribosome-binding GTPase//Dynamin GTPase effector domain -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.37807 BP_3 1732.89 8.68 9911 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 541 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF01436//PF08165//PF00097//PF03884//PF01601//PF14634//PF00643//PF04566//PF10588//PF13639//PF04513//PF00651 NHL repeat//FerA (NUC095) domain//Zinc finger, C3HC4 type (RING finger)//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//zinc-RING finger domain//B-box zinc finger//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Ring finger domain//Baculovirus polyhedron envelope protein, PEP, C terminus//BTB/POZ domain GO:0055114//GO:0006351//GO:0006144//GO:0061025//GO:0006206//GO:0046813 oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process//membrane fusion//pyrimidine nucleobase metabolic process//receptor-mediated virion attachment to host cell GO:0003899//GO:0005198//GO:0008270//GO:0003677//GO:0005515//GO:0016491//GO:0046872 DNA-directed RNA polymerase activity//structural molecule activity//zinc ion binding//DNA binding//protein binding//oxidoreductase activity//metal ion binding GO:0016021//GO:0019028//GO:0005622//GO:0005730//GO:0019031 integral component of membrane//viral capsid//intracellular//nucleolus//viral envelope KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.37809 BP_3 339.05 5.67 3173 642932076 XP_008196848.1 1166 1.3e-124 PREDICTED: pre-mRNA-splicing regulator female-lethal(2)D [Tribolium castaneum]>gi|270011667|gb|EFA08115.1| hypothetical protein TcasGA2_TC005719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y091 702 3.4e-72 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila melanogaster GN=fl(2)d PE=1 SV=2 PF05791//PF17098//PF02932//PF09177//PF02050//PF07361//PF03233//PF09298 Bacillus haemolytic enterotoxin (HBL)//Pre-mRNA-splicing regulator WTAP//Neurotransmitter-gated ion-channel transmembrane region//Syntaxin 6, N-terminal//Flagellar FliJ protein//Cytochrome b562//Aphid transmission protein//Fumarylacetoacetase N-terminal GO:0006570//GO:0009405//GO:0042207//GO:0022900//GO:0006118//GO:0009072//GO:0019089//GO:0048193//GO:0071973//GO:0006935//GO:0006811//GO:0048024 tyrosine metabolic process//pathogenesis//styrene catabolic process//electron transport chain//obsolete electron transport//aromatic amino acid family metabolic process//transmission of virus//Golgi vesicle transport//bacterial-type flagellum-dependent cell motility//chemotaxis//ion transport//regulation of mRNA splicing, via spliceosome GO:0005506//GO:0004334//GO:0020037//GO:0003774//GO:0009055 iron ion binding//fumarylacetoacetase activity//heme binding//motor activity//electron carrier activity GO:0042597//GO:0009288//GO:0005634//GO:0016020 periplasmic space//bacterial-type flagellum//nucleus//membrane KOG2991 Splicing regulator Cluster-8309.37811 BP_3 5694.17 61.33 4767 699049757 AIU39233.1 742 2.8e-75 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 606 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 691 9.5e-71 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF04513//PF08702//PF02601//PF07926//PF16326//PF07851//PF06009//PF14073//PF11365//PF00769//PF15898//PF03577//PF05739//PF10473//PF06160//PF10186 Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//TPR/MLP1/MLP2-like protein//ABC transporter C-terminal domain//TMPIT-like protein//Laminin Domain II//Centrosome localisation domain of Cep57//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//Peptidase family C69//SNARE domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0007165//GO:0051258//GO:0010508//GO:0007155//GO:0006308//GO:0010506//GO:0006606//GO:0000921//GO:0030168//GO:0006508 signal transduction//protein polymerization//positive regulation of autophagy//cell adhesion//DNA catabolic process//regulation of autophagy//protein import into nucleus//septin ring assembly//platelet activation//proteolysis GO:0005198//GO:0019901//GO:0016805//GO:0003677//GO:0042802//GO:0005515//GO:0008855//GO:0043015//GO:0042803//GO:0045502//GO:0008134//GO:0005102//GO:0008092//GO:0030674 structural molecule activity//protein kinase binding//dipeptidase activity//DNA binding//identical protein binding//protein binding//exodeoxyribonuclease VII activity//gamma-tubulin binding//protein homodimerization activity//dynein binding//transcription factor binding//receptor binding//cytoskeletal protein binding//protein binding, bridging GO:0016021//GO:0005940//GO:0005737//GO:0019031//GO:0019898//GO:0019028//GO:0045298//GO:0009318//GO:0005577//GO:0005615//GO:0030286//GO:0005667 integral component of membrane//septin ring//cytoplasm//viral envelope//extrinsic component of membrane//viral capsid//tubulin complex//exodeoxyribonuclease VII complex//fibrinogen complex//extracellular space//dynein complex//transcription factor complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.37812 BP_3 327.13 4.18 4061 642913457 XP_008201020.1 4068 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.1e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00784//PF00023//PF13606 MyTH4 domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.37813 BP_3 598.54 9.49 3331 91089287 XP_971047.1 863 1.8e-89 PREDICTED: derlin-2 [Tribolium castaneum]>gi|270012498|gb|EFA08946.1| hypothetical protein TcasGA2_TC006653 [Tribolium castaneum] 762105781 XR_901040.1 45 1.45736e-11 PREDICTED: Crassostrea gigas derlin-2-like (LOC105333927), transcript variant X2, misc_RNA K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q8BNI4 746 2.8e-77 Derlin-2 OS=Mus musculus GN=Derl2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0858 Predicted membrane protein Cluster-8309.37814 BP_3 17.00 0.74 1402 270003816 EFA00264.1 1006 2.0e-106 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] 255522810 NM_001163846.1 268 6.55542e-136 Tribolium castaneum longitudinals lacking (Lola), transcript variant 9, mRNA -- -- -- -- Q9V5M6 553 2.8e-55 Longitudinals lacking protein, isoforms J/P/Q/S/Z OS=Drosophila melanogaster GN=lola PE=1 SV=4 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37815 BP_3 1611.27 37.79 2347 642920110 XP_008192209.1 1271 6.3e-137 PREDICTED: putative oxidoreductase GLYR1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q161 831 2.7e-87 Putative oxidoreductase GLYR1 homolog OS=Anopheles gambiae GN=AGAP009949 PE=3 SV=5 PF13241//PF03435//PF02558//PF01210//PF03446//PF02826//PF02737//PF14833//PF16519 Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//Ketopantoate reductase PanE/ApbA//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//Tetramerisation domain of TRPM GO:0015940//GO:0006574//GO:0006550//GO:0051262//GO:0006779//GO:0006554//GO:0055114//GO:0006568//GO:0019521//GO:0046168//GO:0019354//GO:0006098//GO:0006633//GO:0018874//GO:0006552//GO:0006631 pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process//protein tetramerization//porphyrin-containing compound biosynthetic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//D-gluconate metabolic process//glycerol-3-phosphate catabolic process//siroheme biosynthetic process//pentose-phosphate shunt//fatty acid biosynthetic process//benzoate metabolic process//leucine catabolic process//fatty acid metabolic process GO:0016616//GO:0004616//GO:0003857//GO:0016491//GO:0051287//GO:0043115//GO:0008677 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//NAD binding//precorrin-2 dehydrogenase activity//2-dehydropantoate 2-reductase activity -- -- KOG0409 Predicted dehydrogenase Cluster-8309.37816 BP_3 16.58 1.70 762 270002078 EEZ98525.1 188 7.8e-12 hypothetical protein TcasGA2_TC001029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37817 BP_3 131.09 3.60 2049 91077452 XP_967401.1 1566 3.4e-171 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270001620|gb|EEZ98067.1| hypothetical protein TcasGA2_TC000474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02338 463 1.1e-44 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3 PF01370//PF13676//PF00106 NAD dependent epimerase/dehydratase family//TIR domain//short chain dehydrogenase GO:0055114//GO:0007165//GO:0008152 oxidation-reduction process//signal transduction//metabolic process GO:0000166//GO:0050662//GO:0003824//GO:0016491//GO:0005515 nucleotide binding//coenzyme binding//catalytic activity//oxidoreductase activity//protein binding -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.37818 BP_3 748.06 5.25 7165 91088413 XP_966659.1 4529 0.0e+00 PREDICTED: TATA-binding protein-associated factor 172 [Tribolium castaneum]>gi|270011757|gb|EFA08205.1| hypothetical protein TcasGA2_TC005832 [Tribolium castaneum] 831521961 XM_012862362.1 245 2.08524e-122 PREDICTED: Fundulus heteroclitus BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (btaf1), mRNA K15192 BTAF1, MOT1 TATA-binding protein-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15192 O14981 2080 1.2e-231 TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 PF15247//PF02262//PF00176//PF02985 Histone RNA hairpin-binding protein RNA-binding domain//CBL proto-oncogene N-terminal domain 1//SNF2 family N-terminal domain//HEAT repeat GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0005515//GO:0004386//GO:0003723//GO:0005524//GO:0003677//GO:0004871 protein binding//helicase activity//RNA binding//ATP binding//DNA binding//signal transducer activity GO:0005634 nucleus KOG0392 SNF2 family DNA-dependent ATPase domain-containing protein Cluster-8309.37819 BP_3 1463.54 33.27 2412 642916810 XP_967695.2 1570 1.4e-171 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 1086 7.6e-117 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0042301//GO:0005515 phosphate ion binding//protein binding GO:0016020//GO:0009523 membrane//photosystem II KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.3782 BP_3 400.20 16.08 1491 1706197 P80684.1 288 3.9e-23 RecName: Full=Pupal cuticle protein C1B; AltName: Full=TM-PCP C1B; Short=TM-C1B [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P80684 288 1.6e-24 Pupal cuticle protein C1B OS=Tenebrio molitor PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37820 BP_3 1027.00 21.21 2626 189237512 XP_972880.2 1894 4.1e-209 PREDICTED: protein phosphatase 1L [Tribolium castaneum]>gi|270007703|gb|EFA04151.1| hypothetical protein TcasGA2_TC014396 [Tribolium castaneum] -- -- -- -- -- K17506 PPM1L, PP2CE protein phosphatase 1L http://www.genome.jp/dbget-bin/www_bget?ko:K17506 Q5SGD2 646 8.7e-66 Protein phosphatase 1L OS=Homo sapiens GN=PPM1L PE=1 SV=1 PF00481 Protein phosphatase 2C GO:0006470 protein dephosphorylation GO:0046872//GO:0004722//GO:0003824 metal ion binding//protein serine/threonine phosphatase activity//catalytic activity GO:0008287 protein serine/threonine phosphatase complex KOG0698 Serine/threonine protein phosphatase Cluster-8309.37822 BP_3 536.74 3.27 8211 642930614 XP_008199194.1 1174 3.9e-125 PREDICTED: protein winged eye isoform X1 [Tribolium castaneum]>gi|642930616|ref|XP_967104.2| PREDICTED: protein winged eye isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3LHL9 631 1.5e-63 Protein winged eye OS=Drosophila melanogaster GN=wge PE=1 SV=1 PF01426//PF13181 BAH domain//Tetratricopeptide repeat -- -- GO:0003682//GO:0005515 chromatin binding//protein binding GO:0000785 chromatin -- -- Cluster-8309.37823 BP_3 264.07 3.50 3932 91090988 XP_974875.1 1812 2.0e-199 PREDICTED: nucleolar protein 14 homolog [Tribolium castaneum]>gi|270014041|gb|EFA10489.1| hypothetical protein TcasGA2_TC012735 [Tribolium castaneum] -- -- -- -- -- K14766 NOP14, UTP2 nucleolar protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K14766 Q9VEJ2 1319 1.2e-143 Nucleolar protein 14 homolog OS=Drosophila melanogaster GN=l(3)07882 PE=2 SV=2 PF08361//PF05859//PF04147 MAATS-type transcriptional repressor, C-terminal region//Mis12 protein//Nop14-like family GO:0007067//GO:0007049 mitotic nuclear division//cell cycle GO:0003677 DNA binding GO:0000775//GO:0005634//GO:0032040 chromosome, centromeric region//nucleus//small-subunit processome KOG2147 Nucleolar protein involved in 40S ribosome biogenesis Cluster-8309.37824 BP_3 2264.25 45.15 2709 91086225 XP_972341.1 3612 0.0e+00 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 766937068 XM_011502671.1 253 2.7935e-127 PREDICTED: Ceratosolen solmsi marchali dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (LOC105364681), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 2906 0.0e+00 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0016020//GO:0008250 membrane//oligosaccharyltransferase complex KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.37826 BP_3 1069.00 15.90 3532 91094575 XP_968718.1 3629 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 1 [Tribolium castaneum]>gi|270016394|gb|EFA12840.1| hypothetical protein TcasGA2_TC006940 [Tribolium castaneum] 410922466 XM_003974655.1 72 1.51379e-26 PREDICTED: Takifugu rubripes protein kinase, cGMP-dependent, type II (prkg2), mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03042 2137 1.5e-238 cGMP-dependent protein kinase, isozyme 1 OS=Drosophila melanogaster GN=Pkg21D PE=1 SV=2 PF00069//PF00125//PF07851//PF06156//PF07714 Protein kinase domain//Core histone H2A/H2B/H3/H4//TMPIT-like protein//Protein of unknown function (DUF972)//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310//GO:0006260 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//DNA replication GO:0004692//GO:0005524//GO:0003677//GO:0004672 cGMP-dependent protein kinase activity//ATP binding//DNA binding//protein kinase activity GO:0016021 integral component of membrane KOG0614 cGMP-dependent protein kinase Cluster-8309.37827 BP_3 18.00 4.42 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37828 BP_3 3522.18 26.20 6771 91085003 XP_973266.1 2982 0.0e+00 PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|642926204|ref|XP_008194828.1| PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|270009020|gb|EFA05468.1| hypothetical protein TcasGA2_TC015651 [Tribolium castaneum] 194742159 XM_001953538.1 227 1.99805e-112 Drosophila ananassae GF17161 (Dana\GF17161), mRNA K00693 GYS glycogen(starch) synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00693 Q9VFC8 2563 1.2e-287 Glycogen [starch] synthase OS=Drosophila melanogaster GN=GlyS PE=1 SV=2 PF00439//PF05693//PF02535 Bromodomain//Glycogen synthase//ZIP Zinc transporter GO:0005985//GO:0055085//GO:0030001//GO:0005982//GO:0005978 sucrose metabolic process//transmembrane transport//metal ion transport//starch metabolic process//glycogen biosynthetic process GO:0004373//GO:0005515//GO:0046873 glycogen (starch) synthase activity//protein binding//metal ion transmembrane transporter activity GO:0016020 membrane KOG3742 Glycogen synthase Cluster-8309.37830 BP_3 211.41 1.66 6419 270007552 EFA04000.1 1548 1.3e-168 hypothetical protein TcasGA2_TC014149 [Tribolium castaneum] 642922772 XM_008195097.1 443 0 PREDICTED: Tribolium castaneum protein muscleblind (LOC100142119), mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 771 6.8e-80 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF00642//PF06733 MMPL family//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//DEAD_2 -- -- GO:0046872//GO:0005524//GO:0004003//GO:0003677 metal ion binding//ATP binding//ATP-dependent DNA helicase activity//DNA binding GO:0005657//GO:0016020 replication fork//membrane KOG2494 C3H1-type Zn-finger protein Cluster-8309.37831 BP_3 28.62 2.58 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37832 BP_3 1205.00 43.69 1621 91076490 XP_972861.1 387 1.4e-34 PREDICTED: CD81 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZR9 146 5.1e-08 Tetraspanin-3 OS=Bos taurus GN=TSPAN3 PE=2 SV=1 PF00335//PF00003//PF12632//PF04103 Tetraspanin family//7 transmembrane sweet-taste receptor of 3 GCPR//Mysoin-binding motif of peroxisomes//CD20-like family GO:0007186 G-protein coupled receptor signaling pathway GO:0017022//GO:0004930 myosin binding//G-protein coupled receptor activity GO:0016021//GO:0016459 integral component of membrane//myosin complex KOG3882 Tetraspanin family integral membrane protein Cluster-8309.37833 BP_3 133.00 3.07 2377 91079768 XP_966889.1 839 8.0e-87 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 P70684 395 1.0e-36 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Cavia porcellus GN=HPGD PE=2 SV=1 PF01370//PF01073//PF00106 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008210//GO:0008152 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//estrogen metabolic process//metabolic process GO:0000166//GO:0003854//GO:0003824//GO:0050662//GO:0016491//GO:0016616 nucleotide binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.37834 BP_3 1870.00 59.56 1805 167234380 NP_001107813.1 1462 3.5e-159 glass bottom boat protein precursor [Tribolium castaneum]>gi|270008197|gb|EFA04645.1| glass bottom boat [Tribolium castaneum] 736191339 XM_010773191.1 51 3.61777e-15 PREDICTED: Notothenia coriiceps bone morphogenetic protein 5 (bmp5), transcript variant X2, mRNA K16621 BMP7 bone morphogenetic protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K16621 P27091 929 9.1e-99 Protein 60A OS=Drosophila melanogaster GN=gbb PE=1 SV=1 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0005576 extracellular region -- -- Cluster-8309.37835 BP_3 3.86 0.31 889 91085777 XP_974360.1 549 1.3e-53 PREDICTED: 60S ribosomal protein L23 [Tribolium castaneum]>gi|270010126|gb|EFA06574.1| hypothetical protein TcasGA2_TC009485 [Tribolium castaneum] 110671519 DQ673438.1 126 3.55058e-57 Diaphorina citri putative ribosomal protein L17/23 mRNA, complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P48159 523 5.4e-52 60S ribosomal protein L23 OS=Drosophila melanogaster GN=RpL23 PE=1 SV=2 PF17123//PF00238//PF09254 RING-like zinc finger//Ribosomal protein L14p/L23e//Restriction endonuclease FokI, C terminal GO:0042254//GO:0006308//GO:0009307//GO:0006412 ribosome biogenesis//DNA catabolic process//DNA restriction-modification system//translation GO:0003735//GO:0008270//GO:0005515//GO:0009036//GO:0003677 structural constituent of ribosome//zinc ion binding//protein binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359//GO:0005840 Type II site-specific deoxyribonuclease complex//ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.37836 BP_3 1321.71 12.68 5315 642912047 XP_008199070.1 2723 6.1e-305 PREDICTED: nuclear factor 1 C-type isoform X1 [Tribolium castaneum]>gi|270014496|gb|EFA10944.1| hypothetical protein TcasGA2_TC001775 [Tribolium castaneum] 642912046 XM_008200848.1 847 0 PREDICTED: Tribolium castaneum nuclear factor 1 C-type (LOC660261), transcript variant X1, mRNA K09172 NFIN nuclear factor I, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09172 P09414 752 9.0e-78 Nuclear factor 1 A-type OS=Rattus norvegicus GN=Nfia PE=1 SV=2 PF00859//PF03165 CTF/NF-I family transcription modulation region//MH1 domain GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005622//GO:0005667 nucleus//intracellular//transcription factor complex KOG3663 Nuclear factor I Cluster-8309.37838 BP_3 92.57 1.24 3889 189242134 XP_968235.2 1493 1.9e-162 PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 1.2e-111 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF13174//PF13181//PF04812//PF13414//PF13176//PF05118//PF02737//PF00515 Tetratricopeptide repeat//Tetratricopeptide repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//TPR repeat//Tetratricopeptide repeat//Aspartyl/Asparaginyl beta-hydroxylase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Tetratricopeptide repeat GO:0006550//GO:0006574//GO:0018874//GO:0006633//GO:0006552//GO:0006554//GO:0055114//GO:0006568//GO:0006631//GO:0018193//GO:0045893 isoleucine catabolic process//valine catabolic process//benzoate metabolic process//fatty acid biosynthetic process//leucine catabolic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//fatty acid metabolic process//peptidyl-amino acid modification//positive regulation of transcription, DNA-templated GO:0016491//GO:0005515//GO:0003857 oxidoreductase activity//protein binding//3-hydroxyacyl-CoA dehydrogenase activity GO:0005634 nucleus KOG3696 Aspartyl beta-hydroxylase Cluster-8309.37839 BP_3 2152.84 18.58 5876 350409232 XP_003488663.1 2292 6.4e-255 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 2 [Bombus impatiens] 642920726 XM_964528.3 475 0 PREDICTED: Tribolium castaneum polypeptide N-acetylgalactosaminyltransferase 2 (LOC658118), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV19 2013 6.0e-224 Polypeptide N-acetylgalactosaminyltransferase 2 OS=Drosophila melanogaster GN=pgant2 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.37840 BP_3 158.74 2.70 3122 642911649 XP_008200687.1 769 1.4e-78 PREDICTED: synapse-associated protein of 47 kDa isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 415 6.3e-39 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.37841 BP_3 50.54 0.93 2909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37843 BP_3 81.23 0.70 5921 642915956 XP_008190826.1 2607 1.9e-291 PREDICTED: LOW QUALITY PROTEIN: protein kinase C, brain isozyme-like [Tribolium castaneum] 759058618 XM_011340249.1 386 0 PREDICTED: Cerapachys biroi protein kinase C, brain isozyme (LOC105280061), transcript variant X3, mRNA K02677 CPKC classical protein kinase C http://www.genome.jp/dbget-bin/www_bget?ko:K02677 P05130 2246 5.8e-251 Protein kinase C, brain isozyme OS=Drosophila melanogaster GN=Pkc53E PE=2 SV=2 PF00628//PF07649//PF07714//PF00069//PF09472//PF00130//PF00433//PF00168//PF02150 PHD-finger//C1-like domain//Protein tyrosine kinase//Protein kinase domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase C terminal domain//C2 domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0015948//GO:0006351//GO:0006144//GO:0016310//GO:0035556//GO:0055114//GO:0006468//GO:0009069//GO:0046656 pyrimidine nucleobase metabolic process//methanogenesis//transcription, DNA-templated//purine nucleobase metabolic process//phosphorylation//intracellular signal transduction//oxidation-reduction process//protein phosphorylation//serine family amino acid metabolic process//folic acid biosynthetic process GO:0004672//GO:0003677//GO:0005515//GO:0047134//GO:0004674//GO:0003899//GO:0005524//GO:0030269 protein kinase activity//DNA binding//protein binding//protein-disulfide reductase activity//protein serine/threonine kinase activity//DNA-directed RNA polymerase activity//ATP binding//tetrahydromethanopterin S-methyltransferase activity GO:0016020//GO:0005730 membrane//nucleolus KOG0694 Serine/threonine protein kinase Cluster-8309.37844 BP_3 510.98 4.28 6047 642923500 XP_008193535.1 431 4.1e-39 PREDICTED: flocculation protein FLO11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37845 BP_3 61.01 4.54 939 642913592 XP_008201077.1 412 1.0e-37 PREDICTED: dentin sialophosphoprotein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37846 BP_3 121.96 0.60 10130 642935327 XP_001809480.2 2489 1.6e-277 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 541 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF00651//PF04513//PF13639//PF10588//PF03884//PF01601//PF14634//PF00097//PF01436 BTB/POZ domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Ring finger domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//NHL repeat GO:0061025//GO:0046813//GO:0055114 membrane fusion//receptor-mediated virion attachment to host cell//oxidation-reduction process GO:0005198//GO:0005515//GO:0016491//GO:0008270//GO:0046872 structural molecule activity//protein binding//oxidoreductase activity//zinc ion binding//metal ion binding GO:0019028//GO:0016021//GO:0019031 viral capsid//integral component of membrane//viral envelope KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.37847 BP_3 901.96 61.47 999 91089633 XP_973579.1 1132 3.5e-121 PREDICTED: guanine nucleotide-binding protein subunit beta-like protein isoform X1 [Tribolium castaneum]>gi|270012613|gb|EFA09061.1| hypothetical protein TcasGA2_TC006776 [Tribolium castaneum] 389610732 AK402355.1 167 6.47271e-80 Papilio polytes mRNA for receptor of activated protein kinase C 1, complete cds, sequence id: Pp-0111 K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1017 3.1e-109 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.37848 BP_3 94.00 4.90 1216 478252244 ENN72672.1 741 9.4e-76 hypothetical protein YQE_10770, partial [Dendroctonus ponderosae]>gi|546675735|gb|ERL86867.1| hypothetical protein D910_04270 [Dendroctonus ponderosae] -- -- -- -- -- K10712 ADO cysteamine dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K10712 Q96SZ5 294 2.6e-25 2-aminoethanethiol dioxygenase OS=Homo sapiens GN=ADO PE=1 SV=2 PF05995//PF07847//PF16867 Cysteine dioxygenase type I//Protein of unknown function (DUF1637)//Dimethlysulfonioproprionate lyase GO:0019530//GO:0006534//GO:0046439//GO:0055114 taurine metabolic process//cysteine metabolic process//L-cysteine metabolic process//oxidation-reduction process GO:0017172//GO:0016702//GO:0005506//GO:0047869 cysteine dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//iron ion binding//dimethylpropiothetin dethiomethylase activity -- -- KOG4281 Uncharacterized conserved protein Cluster-8309.37849 BP_3 196.69 5.44 2036 642929992 XP_975639.2 932 1.1e-97 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6V5K9 261 3.0e-21 Zinc finger protein 474 OS=Mus musculus GN=Znf474 PE=2 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.37851 BP_3 14.99 1.96 660 642929992 XP_975639.2 682 3.5e-69 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QQM4 294 1.4e-25 Zinc finger protein 474 OS=Bos taurus GN=ZNF474 PE=2 SV=1 PF16622//PF01428//PF13465 zinc-finger C2H2-type//AN1-like Zinc finger//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.37853 BP_3 377.91 3.47 5542 642923911 XP_008193924.1 2383 1.7e-265 PREDICTED: nucleolar protein 10 [Tribolium castaneum]>gi|270007790|gb|EFA04238.1| hypothetical protein TcasGA2_TC014492 [Tribolium castaneum] 817185075 XM_012429433.1 112 1.38501e-48 PREDICTED: Orussus abietinus nucleolar protein 10 (LOC105702116), transcript variant X1, mRNA K14788 NOL10, ENP2 ribosome biogenesis protein ENP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14788 Q7T0Q5 1808 3.3e-200 Nucleolar protein 10 OS=Xenopus laevis GN=nol10 PE=2 SV=1 PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus KOG2321 WD40 repeat protein Cluster-8309.37856 BP_3 341.91 2.91 5962 642927920 XP_008195448.1 2122 3.4e-235 PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927922|ref|XP_008195449.1| PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927924|ref|XP_974516.2| PREDICTED: dystroglycan [Tribolium castaneum] 642927923 XM_969423.3 68 4.29383e-24 PREDICTED: Tribolium castaneum dystroglycan (LOC663372), transcript variant X3, mRNA K06265 DAG1 dystroglycan 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06265 Q9TSZ6 506 3.4e-49 Dystroglycan OS=Canis familiaris GN=DAG1 PE=3 SV=1 PF05454//PF03176 Dystroglycan (Dystrophin-associated glycoprotein 1)//MMPL family GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016010//GO:0016020 dystrophin-associated glycoprotein complex//membrane KOG3781 Dystroglycan Cluster-8309.37857 BP_3 92.07 1.07 4440 642913173 XP_008201422.1 3528 0.0e+00 PREDICTED: uncharacterized protein LOC663955 isoform X1 [Tribolium castaneum] 645014380 XM_008205235.1 470 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q10057 146 1.4e-07 Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC1F5.02 PE=3 SV=1 PF00085//PF02382//PF02020//PF01791 Thioredoxin//RTX N-terminal domain//eIF4-gamma/eIF5/eIF2-epsilon//DeoC/LacD family aldolase GO:0045454//GO:0009405 cell redox homeostasis//pathogenesis GO:0005515//GO:0016829//GO:0005509 protein binding//lyase activity//calcium ion binding GO:0005576 extracellular region KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.37859 BP_3 55.35 2.01 1621 795021508 XP_011860288.1 1147 1.0e-122 PREDICTED: putative uncharacterized protein FLJ37770 [Vollenhovia emeryi] 795018260 XM_012003757.1 973 0 PREDICTED: Vollenhovia emeryi putative uncharacterized protein FLJ37770 (LOC105556663), mRNA -- -- -- -- Q7JQ07 342 9.5e-31 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF02070 Neuromedin U GO:0006940 regulation of smooth muscle contraction -- -- -- -- -- -- Cluster-8309.37860 BP_3 109.39 1.03 5393 91093220 XP_967110.1 1945 1.0e-214 PREDICTED: putative Golgi pH regulator C [Tribolium castaneum]>gi|270016591|gb|EFA13037.1| hypothetical protein TcasGA2_TC010568 [Tribolium castaneum] 170065886 XM_001868022.1 246 4.35863e-123 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA -- -- -- -- B5X1G3 1412 2.7e-154 Golgi pH regulator OS=Salmo salar GN=gpr89 PE=2 SV=1 PF00069//PF06293//PF12537//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//The Golgi pH Regulator (GPHR) Family N-terminal//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG2417 Predicted G-protein coupled receptor Cluster-8309.37861 BP_3 177.00 2.40 3844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37864 BP_3 169.65 6.41 1568 478250009 ENN70515.1 416 5.9e-38 hypothetical protein YQE_12691, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VTI8 264 1.0e-21 Protein charybde OS=Drosophila melanogaster GN=chrb PE=2 SV=2 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.37865 BP_3 1560.86 15.34 5196 546677674 ERL88468.1 4240 0.0e+00 hypothetical protein D910_05854 [Dendroctonus ponderosae] 807042134 XM_004536258.2 113 3.60886e-49 PREDICTED: Ceratitis capitata DNA-directed RNA polymerase I subunit RPA2 (LOC101449376), mRNA K03002 RPA2, POLR1B DNA-directed RNA polymerase I subunit RPA2 http://www.genome.jp/dbget-bin/www_bget?ko:K03002 P20028 3304 0.0e+00 DNA-directed RNA polymerase I subunit RPA2 OS=Drosophila melanogaster GN=RpI135 PE=2 SV=2 PF04560//PF00562//PF06883//PF04565//PF00034//PF04561//PF04563//PF13442 RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 6//RNA polymerase I, Rpa2 specific domain//RNA polymerase Rpb2, domain 3//Cytochrome c//RNA polymerase Rpb2, domain 2//RNA polymerase beta subunit//Cytochrome C oxidase, cbb3-type, subunit III GO:0006206//GO:0006118//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//obsolete electron transport//transcription, DNA-templated//purine nucleobase metabolic process GO:0009055//GO:0020037//GO:0003677//GO:0003899 electron carrier activity//heme binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus KOG0216 RNA polymerase I, second largest subunit Cluster-8309.37866 BP_3 560.45 23.14 1459 642926071 XP_008194753.1 1793 1.2e-197 PREDICTED: transcription elongation factor SPT5 [Tribolium castaneum]>gi|270008998|gb|EFA05446.1| hypothetical protein TcasGA2_TC015626 [Tribolium castaneum] -- -- -- -- -- K15172 SUPT5H, SPT5 transcription elongation factor SPT5 http://www.genome.jp/dbget-bin/www_bget?ko:K15172 Q9V460 1020 2.1e-109 Transcription elongation factor SPT5 OS=Drosophila melanogaster GN=Spt5 PE=1 SV=1 -- -- GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter -- -- -- -- KOG1999 RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5 Cluster-8309.37867 BP_3 8.26 0.46 1163 270007560 EFA04008.1 467 5.3e-44 hypothetical protein TcasGA2_TC014157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 267 3.4e-22 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37869 BP_3 32.69 1.20 1610 195118931 XP_002003985.1 1290 2.7e-139 GI20096 [Drosophila mojavensis]>gi|193914560|gb|EDW13427.1| GI20096 [Drosophila mojavensis] 158296763 XM_317113.3 187 8.04942e-91 Anopheles gambiae str. PEST AGAP008345-PA (AgaP_AGAP008345) mRNA, complete cds K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 C1HAB2 966 4.2e-103 Methionine aminopeptidase 2 OS=Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) GN=PAAG_07566 PE=3 SV=1 PF03839//PF02724//PF00283 Translocation protein Sec62//CDC45-like protein//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits GO:0015031//GO:0006270//GO:0015979 protein transport//DNA replication initiation//photosynthesis GO:0008238//GO:0008565 exopeptidase activity//protein transporter activity GO:0016021 integral component of membrane KOG2775 Metallopeptidase Cluster-8309.37870 BP_3 300.67 4.49 3519 642937910 XP_008200354.1 2218 1.5e-246 PREDICTED: zinc finger RNA-binding protein [Tribolium castaneum] 642937909 XM_008202132.1 512 0 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q96KR1 745 3.9e-77 Zinc finger RNA-binding protein OS=Homo sapiens GN=ZFR PE=1 SV=2 PF06220//PF00096 U1 zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.37871 BP_3 17.84 0.60 1725 642912068 XP_008200785.1 1434 5.9e-156 PREDICTED: peroxidase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 1.8e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.37873 BP_3 47.20 0.86 2937 91087199 XP_966953.1 1887 3.0e-208 PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|642929856|ref|XP_008196002.1| PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|270009518|gb|EFA05966.1| hypothetical protein TcasGA2_TC008785 [Tribolium castaneum] -- -- -- -- -- K17917 SNX1_2 sorting nexin-1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17917 Q9CWK8 1113 6.8e-120 Sorting nexin-2 OS=Mus musculus GN=Snx2 PE=1 SV=2 PF00787//PF00782//PF01025 PX domain//Dual specificity phosphatase, catalytic domain//GrpE GO:0007154//GO:0006470//GO:0006457 cell communication//protein dephosphorylation//protein folding GO:0000774//GO:0051087//GO:0042803//GO:0008138//GO:0035091 adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity//protein tyrosine/serine/threonine phosphatase activity//phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.37875 BP_3 159.79 2.86 2984 642919664 XP_008192013.1 934 9.6e-98 PREDICTED: gamma-sarcoglycan [Tribolium castaneum]>gi|270005447|gb|EFA01895.1| hypothetical protein TcasGA2_TC007505 [Tribolium castaneum] -- -- -- -- -- K12563 SGCD delta-sarcoglycan http://www.genome.jp/dbget-bin/www_bget?ko:K12563 P82348 445 2.0e-42 Gamma-sarcoglycan OS=Mus musculus GN=Sgcg PE=1 SV=2 PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016021//GO:0044425//GO:0016012 integral component of membrane//membrane part//sarcoglycan complex KOG3950 Gamma/delta sarcoglycan Cluster-8309.37876 BP_3 7.00 1.34 544 642920916 XP_008192614.1 161 7.6e-09 PREDICTED: outer dense fiber protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37877 BP_3 70.74 1.91 2077 642920914 XP_008192613.1 587 1.2e-57 PREDICTED: outer dense fiber protein 3-B isoform X2 [Tribolium castaneum]>gi|270006132|gb|EFA02580.1| hypothetical protein TcasGA2_TC008298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 252 3.3e-20 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37878 BP_3 1641.33 21.89 3905 91090754 XP_968387.1 495 1.0e-46 PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935819|ref|XP_008198188.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935821|ref|XP_008198189.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|270013960|gb|EFA10408.1| hypothetical protein TcasGA2_TC012647 [Tribolium castaneum] 760445534 XM_011401534.1 51 7.9055e-15 Auxenochlorella protothecoides ADP-ribosylation factor 1 partial mRNA K07937 ARF1 ADP-ribosylation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07937 P61209 488 2.7e-47 ADP-ribosylation factor 1 OS=Drosophila melanogaster GN=Arf79F PE=2 SV=2 PF00025//PF05493 ADP-ribosylation factor family//ATP synthase subunit H GO:0015991//GO:0007264//GO:0015992 ATP hydrolysis coupled proton transport//small GTPase mediated signal transduction//proton transport GO:0015078//GO:0005525 hydrogen ion transmembrane transporter activity//GTP binding GO:0005622//GO:0033179 intracellular//proton-transporting V-type ATPase, V0 domain KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.37880 BP_3 4228.66 79.36 2860 817087360 XP_012266451.1 2016 3.2e-223 PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae]>gi|817087362|ref|XP_012266452.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae] 158299880 XM_319893.4 460 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1902 2.2e-211 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF08168//PF06221//PF00096//PF00270 NUC205 domain//Putative zinc finger motif, C2HC5-type//Zinc finger, C2H2 type//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0005524//GO:0003676 metal ion binding//zinc ion binding//ATP binding//nucleic acid binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.37882 BP_3 60.54 0.66 4729 642931522 XP_008196620.1 1438 5.5e-156 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 1029 6.1e-110 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00640//PF00288 Phosphotyrosine interaction domain (PTB/PID)//GHMP kinases N terminal domain GO:0006012//GO:0046835 galactose metabolic process//carbohydrate phosphorylation GO:0005524//GO:0004335//GO:0005515 ATP binding//galactokinase activity//protein binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.37887 BP_3 36.22 0.60 3223 546676181 ERL87248.1 2281 6.7e-254 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9J0 409 3.2e-38 Mycosubtilin synthase subunit B OS=Bacillus subtilis GN=mycB PE=3 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.37888 BP_3 1690.73 46.53 2043 91082437 XP_970911.1 1132 7.3e-121 PREDICTED: tribbles homolog 2 [Tribolium castaneum] 645019257 XM_001600513.3 107 3.0409e-46 PREDICTED: Nasonia vitripennis tribbles homolog 2-like (LOC100115993), mRNA K08814 TRIB1_2 tribbles homolog 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08814 Q8K4K3 606 2.9e-61 Tribbles homolog 2 OS=Mus musculus GN=Trib2 PE=2 SV=2 PF00539//PF03283//PF07714//PF00069 Transactivating regulatory protein (Tat)//Pectinacetylesterase//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0006355 protein phosphorylation//regulation of transcription, DNA-templated GO:0016787//GO:0005524//GO:0004672//GO:0003700 hydrolase activity//ATP binding//protein kinase activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG0583 Serine/threonine protein kinase Cluster-8309.37890 BP_3 994.97 20.00 2690 91087173 XP_975394.1 1602 3.0e-175 PREDICTED: E3 ubiquitin-protein ligase MYLIP [Tribolium castaneum]>gi|270009571|gb|EFA06019.1| hypothetical protein TcasGA2_TC008849 [Tribolium castaneum] -- -- -- -- -- K10637 MYLIP, MIR E3 ubiquitin-protein ligase MYLIP http://www.genome.jp/dbget-bin/www_bget?ko:K10637 Q8WY64 805 3.2e-84 E3 ubiquitin-protein ligase MYLIP OS=Homo sapiens GN=MYLIP PE=1 SV=2 PF00097//PF14634//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Ring finger domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.37891 BP_3 321.16 4.40 3812 270011657 EFA08105.1 1533 4.3e-167 hypothetical protein TcasGA2_TC005709 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.25505e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.9e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF01213//PF00622//PF07525 Adenylate cyclase associated (CAP) N terminal//SPRY domain//SOCS box GO:0007010//GO:0035556 cytoskeleton organization//intracellular signal transduction GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.37892 BP_3 213.00 34.41 590 478255041 ENN75273.1 888 4.1e-93 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 657554958 XM_008283745.1 141 1.05914e-65 PREDICTED: Stegastes partitus phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 814 6.4e-86 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF01409//PF15048//PF00152//PF00587 tRNA synthetases class II core domain (F)//Organic solute transporter subunit beta protein//tRNA synthetases class II (D, K and N)//tRNA synthetase class II core domain (G, H, P, S and T) GO:0006810//GO:0015721//GO:0006418//GO:0043039 transport//bile acid and bile salt transport//tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0005524//GO:0046982//GO:0000049//GO:0005215//GO:0000166//GO:0004812 ATP binding//protein heterodimerization activity//tRNA binding//transporter activity//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005886//GO:0005737 plasma membrane//cytoplasm KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.37894 BP_3 21.50 1.60 941 642937480 XP_008198856.1 195 1.5e-12 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37895 BP_3 1025.68 14.98 3593 91090686 XP_974615.1 1908 1.3e-210 PREDICTED: FGGY carbohydrate kinase domain-containing protein [Tribolium castaneum]>gi|270013302|gb|EFA09750.1| hypothetical protein TcasGA2_TC011889 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCD1 1405 1.2e-153 FGGY carbohydrate kinase domain-containing protein OS=Xenopus laevis GN=fggy PE=2 SV=2 PF00370//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.37898 BP_3 8.53 0.31 1634 270001130 EEZ97577.1 260 7.5e-20 hypothetical protein TcasGA2_TC011439 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37899 BP_3 216.98 3.03 3738 642937495 XP_008198863.1 967 1.8e-101 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] 462328819 APGK01040556.1 149 2.51691e-69 Dendroctonus ponderosae Seq01040566, whole genome shotgun sequence -- -- -- -- Q86B87 360 1.8e-32 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.379 BP_3 41.00 0.74 2950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37900 BP_3 2385.12 17.99 6681 91076704 XP_972106.1 1365 2.3e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 7.1e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF13371//PF08030//PF04142//PF08449//PF10147//PF16685//PF13639//PF14634//PF12678//PF00097//PF01297//PF00892//PF00175 Tetratricopeptide repeat//Ferric reductase NAD binding domain//Nucleotide-sugar transporter//UAA transporter family//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//zinc RING finger of MSL2//Ring finger domain//zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-uptake complex component A periplasmic//EamA-like transporter family//Oxidoreductase NAD-binding domain GO:0055085//GO:0007049//GO:0015780//GO:0055114//GO:0030001//GO:0008643 transmembrane transport//cell cycle//nucleotide-sugar transport//oxidation-reduction process//metal ion transport//carbohydrate transport GO:0005351//GO:0005338//GO:0008270//GO:0061630//GO:0016491//GO:0005515//GO:0046872 sugar:proton symporter activity//nucleotide-sugar transmembrane transporter activity//zinc ion binding//ubiquitin protein ligase activity//oxidoreductase activity//protein binding//metal ion binding GO:0016021//GO:0005634//GO:0000139//GO:0016020 integral component of membrane//nucleus//Golgi membrane//membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.37901 BP_3 2350.40 22.96 5226 749735952 XP_011154160.1 3304 0.0e+00 PREDICTED: armadillo segment polarity protein isoform X1 [Harpegnathos saltator]>gi|307212553|gb|EFN88276.1| Armadillo segment polarity protein [Harpegnathos saltator] 642934620 XM_008199519.1 628 0 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 3204 0.0e+00 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 PF02985//PF07646//PF10508//PF00514//PF01344//PF01602 HEAT repeat//Kelch motif//Proteasome non-ATPase 26S subunit//Armadillo/beta-catenin-like repeat//Kelch motif//Adaptin N terminal region GO:0043248//GO:0016192//GO:0006886 proteasome assembly//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.37902 BP_3 14.64 0.59 1496 642935880 XP_008198210.1 412 1.6e-37 PREDICTED: uncharacterized protein LOC103314310 [Tribolium castaneum] 642935879 XM_008199988.1 39 1.3992e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103314310 (LOC103314310), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37904 BP_3 91.51 0.91 5146 270006638 EFA03086.1 1900 1.6e-209 hypothetical protein TcasGA2_TC012992 [Tribolium castaneum] 642925120 XM_008195954.1 487 0 PREDICTED: Tribolium castaneum YTH domain-containing family protein 3 (LOC659651), transcript variant X1, mRNA -- -- -- -- Q8BYK6 754 5.1e-78 YTH domain-containing family protein 3 OS=Mus musculus GN=Ythdf3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1901 Uncharacterized high-glucose-regulated protein Cluster-8309.37905 BP_3 632.93 16.06 2191 270006638 EFA03086.1 1933 1.0e-213 hypothetical protein TcasGA2_TC012992 [Tribolium castaneum] 642925120 XM_008195954.1 504 0 PREDICTED: Tribolium castaneum YTH domain-containing family protein 3 (LOC659651), transcript variant X1, mRNA -- -- -- -- Q8BYK6 754 2.2e-78 YTH domain-containing family protein 3 OS=Mus musculus GN=Ythdf3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1901 Uncharacterized high-glucose-regulated protein Cluster-8309.37907 BP_3 1403.00 58.13 1455 189237082 XP_001810630.1 1367 2.9e-148 PREDICTED: WD repeat-containing protein 55 homolog [Tribolium castaneum]>gi|270007253|gb|EFA03701.1| hypothetical protein TcasGA2_TC013806 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IF90 1010 3.0e-108 WD repeat-containing protein 55 homolog OS=Aedes aegypti GN=AAEL006422 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2444 WD40 repeat protein Cluster-8309.37908 BP_3 1220.10 4.33 13876 270013752 EFA10200.1 800 1.5e-81 hypothetical protein TcasGA2_TC012395 [Tribolium castaneum] 642934667 XM_008199538.1 207 5.38737e-101 PREDICTED: Tribolium castaneum nuclear receptor-binding protein homolog (LOC661173), mRNA K08875 NRBP nuclear receptor-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08875 Q297L2 566 8.7e-56 Nuclear receptor-binding protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=Madm PE=3 SV=2 PF00069//PF07714//PF01529//PF00767//PF01365 Protein kinase domain//Protein tyrosine kinase//DHHC palmitoyltransferase//Potyvirus coat protein//RIH domain GO:0006468//GO:0070588//GO:0006816 protein phosphorylation//calcium ion transmembrane transport//calcium ion transport GO:0005524//GO:0005262//GO:0004672//GO:0008270 ATP binding//calcium channel activity//protein kinase activity//zinc ion binding GO:0019028//GO:0016020 viral capsid//membrane KOG1266 Protein kinase Cluster-8309.37909 BP_3 82.01 1.05 4044 332373020 AEE61651.1 619 4.4e-61 unknown [Dendroctonus ponderosae]>gi|478250449|gb|ENN70944.1| hypothetical protein YQE_12346, partial [Dendroctonus ponderosae]>gi|546677327|gb|ERL88184.1| hypothetical protein D910_05572 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37910 BP_3 729.83 9.80 3881 91078996 XP_974675.1 1185 9.8e-127 PREDICTED: zinc transporter ZIP1 [Tribolium castaneum]>gi|270003679|gb|EFA00127.1| hypothetical protein TcasGA2_TC002943 [Tribolium castaneum] -- -- -- -- -- K14709 SLC39A1_2_3, ZIP1_2_3 solute carrier family 39 (zinc transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14709 P59889 292 1.4e-24 Zinc transporter ZIP1 OS=Danio rerio GN=slc39a1 PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085//GO:0044765 metal ion transport//transmembrane transport//single-organism transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.37912 BP_3 750.29 6.58 5789 642924882 XP_008194082.1 2220 1.4e-246 PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|642924884|ref|XP_008194083.1| PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|270008015|gb|EFA04463.1| hypothetical protein TcasGA2_TC014767 [Tribolium castaneum] 795080210 XM_012021821.1 347 3.34759e-179 PREDICTED: Vollenhovia emeryi serine/threonine-protein kinase 25 (LOC105567182), transcript variant X6, mRNA K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 B0LT89 1090 6.3e-117 Serine/threonine-protein kinase 24 OS=Rattus norvegicus GN=Stk24 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0201 Serine/threonine protein kinase Cluster-8309.37913 BP_3 3178.12 94.19 1918 478257768 ENN77911.1 1426 5.5e-155 hypothetical protein YQE_05588, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI17 442 2.9e-42 Protein yellow OS=Drosophila yakuba GN=y PE=3 SV=1 PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.37914 BP_3 49.88 0.48 5260 642920483 XP_008192370.1 2537 2.2e-283 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86W92 885 3.4e-93 Liprin-beta-1 OS=Homo sapiens GN=PPFIBP1 PE=1 SV=2 PF02198//PF01763//PF00536//PF02601//PF07647//PF01496 Sterile alpha motif (SAM)/Pointed domain//Herpesvirus UL6 like//SAM domain (Sterile alpha motif)//Exonuclease VII, large subunit//SAM domain (Sterile alpha motif)//V-type ATPase 116kDa subunit family GO:0006308//GO:0015992//GO:0006323//GO:0015991 DNA catabolic process//proton transport//DNA packaging//ATP hydrolysis coupled proton transport GO:0015078//GO:0043565//GO:0005515//GO:0008855 hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//protein binding//exodeoxyribonuclease VII activity GO:0009318//GO:0033179//GO:0005634 exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain//nucleus KOG0249 LAR-interacting protein and related proteins Cluster-8309.37915 BP_3 44.26 0.57 4009 478260883 ENN80520.1 656 2.2e-65 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IZR5 180 1.4e-11 CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Homo sapiens GN=CMTM4 PE=1 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane KOG4788 Members of chemokine-like factor super family and related proteins Cluster-8309.37916 BP_3 2843.00 23.37 6156 805796841 XP_003704470.2 983 4.1e-103 PREDICTED: neuronal calcium sensor 2 isoform X1 [Megachile rotundata] 817206217 XM_012423619.1 296 7.98606e-151 PREDICTED: Orussus abietinus neuronal calcium sensor 2 (LOC105698961), mRNA -- -- -- -- P36609 641 7.7e-65 Neuronal calcium sensor 2 OS=Caenorhabditis elegans GN=ncs-2 PE=2 SV=2 PF13202//PF00036//PF12763//PF13499//PF13833//PF10591//PF13405//PF01763 EF hand//EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Herpesvirus UL6 like GO:0007165//GO:0006323 signal transduction//DNA packaging GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.37917 BP_3 1593.28 249.88 599 91092686 XP_971550.1 229 1.1e-16 PREDICTED: ATPase inhibitor mai-2, mitochondrial [Tribolium castaneum]>gi|270014813|gb|EFA11261.1| hypothetical protein TcasGA2_TC010795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8XZB0 169 4.0e-11 ATPase inhibitor mai-2, mitochondrial OS=Caenorhabditis briggsae GN=mai-2 PE=3 SV=1 PF07851//PF04568//PF08702 TMPIT-like protein//Mitochondrial ATPase inhibitor, IATP//Fibrinogen alpha/beta chain family GO:0030168//GO:0032780//GO:0007165//GO:0051258 platelet activation//negative regulation of ATPase activity//signal transduction//protein polymerization GO:0005102//GO:0030674//GO:0042030 receptor binding//protein binding, bridging//ATPase inhibitor activity GO:0005577//GO:0005739//GO:0016021 fibrinogen complex//mitochondrion//integral component of membrane -- -- Cluster-8309.37918 BP_3 7640.21 87.30 4510 91083171 XP_972171.1 2439 4.5e-272 PREDICTED: mRNA-capping enzyme [Tribolium castaneum]>gi|270006979|gb|EFA03427.1| hypothetical protein TcasGA2_TC013414 [Tribolium castaneum] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 O55236 1662 2.3e-183 mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1 PF00102//PF01331//PF15182//PF03919//PF00782 Protein-tyrosine phosphatase//mRNA capping enzyme, catalytic domain//Otospiralin//mRNA capping enzyme, C-terminal domain//Dual specificity phosphatase, catalytic domain GO:0006370//GO:0035335//GO:0006397//GO:0007605//GO:0006570//GO:0006470 7-methylguanosine mRNA capping//peptidyl-tyrosine dephosphorylation//mRNA processing//sensory perception of sound//tyrosine metabolic process//protein dephosphorylation GO:0004651//GO:0004725//GO:0004484//GO:0008138 polynucleotide 5'-phosphatase activity//protein tyrosine phosphatase activity//mRNA guanylyltransferase activity//protein tyrosine/serine/threonine phosphatase activity GO:0005634 nucleus KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.37919 BP_3 806.30 8.15 5059 546673374 ERL84995.1 488 8.5e-46 hypothetical protein D910_02418 [Dendroctonus ponderosae] -- -- -- -- -- K00669 AANAT arylalkylamine N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00669 Q94521 257 2.1e-20 Dopamine N-acetyltransferase OS=Drosophila melanogaster GN=Dat PE=1 SV=1 PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.37921 BP_3 292.90 17.11 1117 270002027 EEZ98474.1 452 2.8e-42 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWD0 135 6.6e-07 Gametocyte-specific factor 1-like OS=Mus musculus GN=Gtsf1l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4376 Uncharacterized conserved protein Cluster-8309.37922 BP_3 522.41 6.34 4263 642928729 XP_008199757.1 2652 8.4e-297 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 746860384 XM_011062730.1 215 5.87849e-106 PREDICTED: Acromyrmex echinatior phosphoenolpyruvate carboxykinase [GTP]-like (LOC105149957), transcript variant X4, mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 2332 4.4e-261 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37923 BP_3 1465.93 23.40 3311 642910207 XP_008198406.1 2005 6.9e-222 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 245 3.4e-19 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37925 BP_3 144.25 21.18 620 642938589 XP_008199854.1 397 3.7e-36 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X3 [Tribolium castaneum] 642938588 XM_008201632.1 200 1.7777e-98 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF12424//PF00844 Plasma membrane calcium transporter ATPase C terminal//Geminivirus coat protein/nuclear export factor BR1 family GO:0006816 calcium ion transport GO:0005198//GO:0005388 structural molecule activity//calcium-transporting ATPase activity GO:0016529//GO:0019028 sarcoplasmic reticulum//viral capsid -- -- Cluster-8309.37926 BP_3 144.35 1.04 7010 642938587 XP_008199853.1 4992 0.0e+00 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X2 [Tribolium castaneum] 442614369 NM_001014687.4 380 0 Drosophila melanogaster plasma membrane calcium ATPase (PMCA), transcript variant N, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 P11505 3442 0.0e+00 Plasma membrane calcium-transporting ATPase 1 OS=Rattus norvegicus GN=Atp2b1 PE=2 SV=2 PF00122//PF12424 E1-E2 ATPase//Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0046872//GO:0000166//GO:0005388 metal ion binding//nucleotide binding//calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum KOG0204 Calcium transporting ATPase Cluster-8309.37928 BP_3 43.63 0.52 4352 642925626 XP_008194646.1 2751 2.8e-308 PREDICTED: endothelin-converting enzyme 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 P42891 1472 2.4e-161 Endothelin-converting enzyme 1 OS=Bos taurus GN=ECE1 PE=1 SV=2 PF05649//PF01447//PF01431 Peptidase family M13//Thermolysin metallopeptidase, catalytic domain//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.37929 BP_3 999.46 10.09 5066 642927880 XP_008195434.1 2844 0.0e+00 PREDICTED: zinc finger protein 608-like isoform X1 [Tribolium castaneum] 642927883 XM_008197214.1 252 1.89066e-126 PREDICTED: Tribolium castaneum zinc finger protein 608-like (LOC662416), transcript variant X3, mRNA -- -- -- -- O15014 456 1.8e-43 Zinc finger protein 609 OS=Homo sapiens GN=ZNF609 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37930 BP_3 43.55 0.88 2672 189236706 XP_974173.2 1504 6.9e-164 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 341 3.32251e-176 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 636 1.3e-64 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.37932 BP_3 100.30 1.05 4906 270004228 EFA00676.1 1543 3.8e-168 hypothetical protein TcasGA2_TC003553 [Tribolium castaneum] 642916460 XM_008192815.1 144 1.99271e-66 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 P58003 894 2.8e-94 Sestrin-1 OS=Xenopus laevis GN=sesn1 PE=2 SV=1 PF04636 PA26 p53-induced protein (sestrin) GO:1901031 regulation of response to reactive oxygen species -- -- GO:0005634 nucleus KOG3746 Uncharacterized conserved protein Cluster-8309.37933 BP_3 3753.00 76.06 2670 91094833 XP_971377.1 1765 3.8e-194 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [Tribolium castaneum]>gi|270006555|gb|EFA03003.1| hypothetical protein TcasGA2_TC010426 [Tribolium castaneum] -- -- -- -- -- K12667 SWP1, RPN2 oligosaccharyltransferase complex subunit delta (ribophorin II) http://www.genome.jp/dbget-bin/www_bget?ko:K12667 Q9GL01 497 1.7e-48 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Sus scrofa GN=RPN2 PE=2 SV=1 PF05817 Oligosaccharyltransferase subunit Ribophorin II GO:0006487 protein N-linked glycosylation -- -- GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex KOG2447 Oligosaccharyltransferase, delta subunit (ribophorin II) Cluster-8309.37935 BP_3 17301.99 443.76 2171 189237461 XP_001807996.1 214 2.2e-14 PREDICTED: tubby-related protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37936 BP_3 45.00 7.22 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37937 BP_3 44.50 1.69 1562 642918280 XP_008191442.1 2126 3.0e-236 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 195430887 XM_002063444.1 277 7.27107e-141 Drosophila willistoni GK21381 (Dwil\GK21381), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 Q27HV0 1713 9.7e-190 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Sus scrofa GN=OGT PE=2 SV=1 PF05009//PF13181//PF13414//PF13176//PF13371//PF00515//PF02259//PF13374 Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat GO:0016032 viral process GO:0005515 protein binding GO:0042025 host cell nucleus KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.37938 BP_3 1254.00 46.45 1593 91090280 XP_970932.1 887 1.4e-92 PREDICTED: josephin-1 [Tribolium castaneum]>gi|270013789|gb|EFA10237.1| hypothetical protein TcasGA2_TC012435 [Tribolium castaneum] 665808527 XM_008554369.1 59 1.13726e-19 PREDICTED: Microplitis demolitor josephin-2 (LOC103574822), transcript variant X3, mRNA K15235 JOSD josephin http://www.genome.jp/dbget-bin/www_bget?ko:K15235 Q9W422 543 4.6e-54 Josephin-like protein OS=Drosophila melanogaster GN=CG3781 PE=2 SV=3 PF02099 Josephin -- -- GO:0008242 omega peptidase activity -- -- KOG2934 Uncharacterized conserved protein, contains Josephin domain Cluster-8309.37939 BP_3 2786.00 26.20 5417 270004992 EFA01440.1 863 3.0e-89 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 544 1.2e-53 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF00642//PF13895 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Immunoglobulin domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.37940 BP_3 955.97 3.69 12767 642918534 XP_008191512.1 3762 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.62865e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1207 3.7e-130 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02383//PF05461//PF13895 SacI homology domain//Apolipoprotein L//Immunoglobulin domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0042578//GO:0008289 protein binding//phosphoric ester hydrolase activity//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.37941 BP_3 1202.10 5.03 11802 642918534 XP_008191512.1 3864 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.20197e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1744 1.9e-192 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF05461//PF13895 Apolipoprotein L//Immunoglobulin domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0008289 protein binding//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.37942 BP_3 41.29 1.73 1443 748995286 AJE75665.1 583 2.3e-57 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q02401 419 1.0e-39 Lactase-phlorizin hydrolase OS=Rattus norvegicus GN=Lct PE=2 SV=2 PF00232//PF07243 Glycosyl hydrolase family 1//Phlebovirus glycoprotein G1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016021//GO:0019012 integral component of membrane//virion KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.37944 BP_3 6.81 0.52 923 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37945 BP_3 107.52 4.06 1567 642915255 XP_008190545.1 1027 8.3e-109 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19573 ATAT1, MEC17 alpha-tubulin N-acetyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19573 Q16Y34 630 3.7e-64 Alpha-tubulin N-acetyltransferase OS=Aedes aegypti GN=AAEL008679 PE=3 SV=1 PF13673//PF03494//PF13508//PF05301//PF00583 Acetyltransferase (GNAT) domain//Beta-amyloid peptide (beta-APP)//Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Acetyltransferase (GNAT) family GO:0042967//GO:0071929 acyl-carrier-protein biosynthetic process//alpha-tubulin acetylation GO:0008080//GO:0019799 N-acetyltransferase activity//tubulin N-acetyltransferase activity GO:0005874//GO:0045298//GO:0016021 microtubule//tubulin complex//integral component of membrane KOG4601 Uncharacterized conserved protein Cluster-8309.37946 BP_3 1109.00 12.28 4643 91081989 XP_968889.1 1935 1.3e-213 PREDICTED: large subunit GTPase 1 homolog [Tribolium castaneum]>gi|270007374|gb|EFA03822.1| hypothetical protein TcasGA2_TC013937 [Tribolium castaneum] -- -- -- -- -- K14539 LSG1 large subunit GTPase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14539 Q9W590 1552 1.3e-170 Large subunit GTPase 1 homolog OS=Drosophila melanogaster GN=Ns3 PE=1 SV=1 PF02421//PF04722//PF04548//PF01926//PF03193 Ferrous iron transport protein B//Ssu72-like protein//AIG1 family//50S ribosome-binding GTPase//Protein of unknown function, DUF258 GO:0006397//GO:0006470//GO:0015684 mRNA processing//protein dephosphorylation//ferrous iron transport GO:0015093//GO:0003924//GO:0005525//GO:0004721 ferrous iron transmembrane transporter activity//GTPase activity//GTP binding//phosphoprotein phosphatase activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG1424 Predicted GTP-binding protein MMR1 Cluster-8309.37947 BP_3 815.65 5.42 7541 270003910 EFA00358.1 1564 2.2e-170 hypothetical protein TcasGA2_TC003200 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37948 BP_3 4777.47 118.74 2231 91089745 XP_975162.1 1631 1.1e-178 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 1036 4.4e-111 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family -- -- GO:0005524//GO:0016773//GO:0016772 ATP binding//phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring phosphorus-containing groups GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.37950 BP_3 23.94 0.85 1657 642915807 XP_008200086.1 1220 3.7e-131 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 766926462 XM_011496875.1 184 3.85679e-89 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- O94967 773 1.0e-80 WD repeat-containing protein 47 OS=Homo sapiens GN=WDR47 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.37952 BP_3 26.41 2.77 752 549438533 AGX25155.1 326 7.7e-28 aminopeptidase N-like protein, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03461 TRCF domain GO:0006281 DNA repair -- -- -- -- -- -- Cluster-8309.37953 BP_3 314.67 10.85 1690 546680809 ERL91015.1 1480 2.7e-161 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 1162 8.2e-126 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.37956 BP_3 7893.00 518.12 1026 817220079 XP_012285695.1 949 6.0e-100 PREDICTED: 60S ribosomal protein L7 [Orussus abietinus] 264667340 GU120406.1 272 2.84375e-138 Chrysomela tremulae ribosomal protein L7 (RpL7) mRNA, complete cds K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 P32100 787 1.5e-82 60S ribosomal protein L7 OS=Drosophila melanogaster GN=RpL7 PE=1 SV=2 PF00336//PF02201 DNA polymerase (viral) C-terminal domain//SWIB/MDM2 domain GO:0051252 regulation of RNA metabolic process GO:0005515//GO:0004523 protein binding//RNA-DNA hybrid ribonuclease activity -- -- KOG3184 60S ribosomal protein L7 Cluster-8309.37957 BP_3 84.60 0.60 7113 91086723 XP_970869.1 1565 1.6e-170 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 1.88299e-08 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 840 7.5e-88 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF08022//PF02535 FAD-binding domain//ZIP Zinc transporter GO:0055114//GO:0055085//GO:0030001 oxidation-reduction process//transmembrane transport//metal ion transport GO:0016491//GO:0046873 oxidoreductase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.37958 BP_3 30.80 3.05 779 91091124 XP_969500.1 495 2.0e-47 PREDICTED: calcium-binding protein E63-1 [Tribolium castaneum]>gi|642936333|ref|XP_008198399.1| PREDICTED: calcium-binding protein E63-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48593 423 1.9e-40 Calcium-binding protein E63-1 OS=Drosophila melanogaster GN=Eip63F-1 PE=2 SV=2 PF12763//PF13202//PF13499//PF13833//PF10591//PF00036//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.37959 BP_3 1557.00 18.95 4252 470012399 AGI03912.1 868 6.2e-90 ADP-ribosylation factor 4 [Leptinotarsa decemlineata] 152001115 BC147893.1 106 2.29562e-45 Bos taurus ADP-ribosylation factor-like 4C, mRNA (cDNA clone MGC:152553 IMAGE:8429416), complete cds K07945 ARL4 ADP-ribosylation factor-like protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K07945 P61213 541 2.1e-53 ADP-ribosylation factor-like protein 4A OS=Mus musculus GN=Arl4a PE=2 SV=1 PF00025//PF10717//PF08477//PF01127//PF01926//PF00503//PF04670//PF00071 ADP-ribosylation factor family//Occlusion-derived virus envelope protein ODV-E18//Ras of Complex, Roc, domain of DAPkinase//Succinate dehydrogenase/Fumarate reductase transmembrane subunit//50S ribosome-binding GTPase//G-protein alpha subunit//Gtr1/RagA G protein conserved region//Ras family GO:0007165//GO:0007264//GO:0007186 signal transduction//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0016627//GO:0005525//GO:0019001//GO:0004871 GTPase activity//G-protein beta/gamma-subunit complex binding//oxidoreductase activity, acting on the CH-CH group of donors//GTP binding//guanyl nucleotide binding//signal transducer activity GO:0019031 viral envelope KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.37960 BP_3 238.00 2.93 4209 102939 522 8.1e-50 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 330 6.1e-29 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.37964 BP_3 64.00 38.38 369 282720995 NP_001164248.1 371 2.3e-33 cytochrome P450 9Z4 [Tribolium castaneum]>gi|270012794|gb|EFA09242.1| cytochrome P450 9Z4 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 247 2.3e-20 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0046872//GO:0016705 heme binding//iron ion binding//oxidoreductase activity//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.37965 BP_3 264.06 2.79 4857 642938005 XP_008199168.1 1238 8.8e-133 PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like isoform X2 [Tribolium castaneum]>gi|270015674|gb|EFA12122.1| hypothetical protein TcasGA2_TC002268 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 P59644 534 1.6e-52 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Mus musculus GN=Inpp5j PE=2 SV=2 PF06330 Trichodiene synthase (TRI5) GO:0016106//GO:0016114//GO:0046854 sesquiterpenoid biosynthetic process//terpenoid biosynthetic process//phosphatidylinositol phosphorylation GO:0045482 trichodiene synthase activity -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.37966 BP_3 5472.23 226.54 1456 270004078 EFA00526.1 547 3.5e-53 hypothetical protein TcasGA2_TC003391 [Tribolium castaneum] 662204498 XM_008477405.1 35 2.27726e-06 PREDICTED: Diaphorina citri uncharacterized LOC103512635 (LOC103512635), mRNA -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.37967 BP_3 762.58 4.46 8525 642938749 XP_008199873.1 2394 1.4e-266 PREDICTED: cytosolic purine 5'-nucleotidase isoform X3 [Tribolium castaneum] 41393060 NM_201427.1 39 8.12387e-08 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1747 6.0e-193 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 PF09126 Restriction endonuclease NaeI GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0009036 Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.37968 BP_3 222.63 0.97 11315 642925096 XP_008194167.1 5395 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum]>gi|642925098|ref|XP_008194168.1| PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum] 642925099 XM_964960.2 404 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9C102 3369 0.0e+00 Putative glutamate synthase [NADPH] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=glt1 PE=2 SV=1 PF01134//PF00869//PF13241//PF05834//PF00833//PF00287//PF01494//PF07992//PF01210//PF01493//PF00070//PF13443//PF01645//PF04183//PF01266//PF12831//PF01593//PF01070//PF04898//PF00743 Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains//Putative NAD(P)-binding//Lycopene cyclase protein//Ribosomal S17//Sodium / potassium ATPase beta chain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//GXGXG motif//Pyridine nucleotide-disulphide oxidoreductase//Cro/C1-type HTH DNA-binding domain//Conserved region in glutamate synthase//IucA / IucC family//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//FMN-dependent dehydrogenase//Glutamate synthase central domain//Flavin-binding monooxygenase-like GO:0006537//GO:0008033//GO:0006826//GO:0006412//GO:0006813//GO:0006807//GO:0006779//GO:0055114//GO:0042254//GO:0006814//GO:0046168//GO:0008152//GO:0019354//GO:0019290//GO:0016117 glutamate biosynthetic process//tRNA processing//iron ion transport//translation//potassium ion transport//nitrogen compound metabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//ribosome biogenesis//sodium ion transport//glycerol-3-phosphate catabolic process//metabolic process//siroheme biosynthetic process//siderophore biosynthetic process//carotenoid biosynthetic process GO:0071949//GO:0016638//GO:0043565//GO:0015343//GO:0051287//GO:0050661//GO:0004499//GO:0016705//GO:0050660//GO:0016616//GO:0003735//GO:0016491//GO:0046983//GO:0043115//GO:0015930 FAD binding//oxidoreductase activity, acting on the CH-NH2 group of donors//sequence-specific DNA binding//siderophore transmembrane transporter activity//NAD binding//NADP binding//N,N-dimethylaniline monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural constituent of ribosome//oxidoreductase activity//protein dimerization activity//precorrin-2 dehydrogenase activity//glutamate synthase activity GO:0005622//GO:0005840//GO:0005890 intracellular//ribosome//sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.37970 BP_3 249.99 3.31 3930 642917757 XP_008191356.1 425 1.3e-38 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 54 1.71016e-16 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.37971 BP_3 1091.44 32.77 1897 91076410 XP_969526.1 1383 5.3e-150 PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002563|gb|EEZ99010.1| hypothetical protein TcasGA2_TC004878 [Tribolium castaneum] 731510745 XM_010600440.1 62 2.92133e-21 PREDICTED: Loxodonta africana aldose reductase-related protein 2-like (LOC100673621), mRNA K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15122 974 5.8e-104 Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.37972 BP_3 127.22 1.25 5211 546672885 ERL84608.1 2106 2.1e-233 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1003 6.9e-107 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00108//PF08545//PF00107 Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Zinc-binding dehydrogenase GO:0042967//GO:0055114//GO:0008152//GO:0006633 acyl-carrier-protein biosynthetic process//oxidation-reduction process//metabolic process//fatty acid biosynthetic process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.37973 BP_3 191889.57 10412.39 1180 -- -- -- -- -- 327302703 XM_003235996.1 43 6.55312e-11 Trichophyton rubrum CBS 118892 hypothetical protein (TERG_08771) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37974 BP_3 19.19 4.20 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37975 BP_3 394.91 9.00 2406 478255178 ENN75407.1 459 9.3e-43 hypothetical protein YQE_07958, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DAK4 165 4.7e-10 Fatty acid-binding protein 12 OS=Mus musculus GN=Fabp12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.37976 BP_3 1086.55 7.96 6870 270009164 EFA05612.1 4289 0.0e+00 hypothetical protein TcasGA2_TC015818 [Tribolium castaneum] 827557043 XM_012694365.1 41 5.05563e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2570 1.8e-288 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF00403//PF05138//PF00122//PF01529 Heavy-metal-associated domain//Phenylacetic acid catabolic protein//E1-E2 ATPase//DHHC palmitoyltransferase GO:0010124//GO:0030001 phenylacetate catabolic process//metal ion transport GO:0046872//GO:0000166//GO:0008270 metal ion binding//nucleotide binding//zinc ion binding -- -- KOG0207 Cation transport ATPase Cluster-8309.37977 BP_3 78.23 1.38 3023 91094409 XP_967943.1 1028 1.2e-108 PREDICTED: acyl-CoA Delta(11) desaturase [Tribolium castaneum]>gi|270016351|gb|EFA12797.1| hypothetical protein TcasGA2_TC014819 [Tribolium castaneum]>gi|576636744|gb|AHH30814.1| fatty acid desaturase D7 [Tribolium castaneum] 817052910 XM_012403667.1 71 4.65187e-26 PREDICTED: Athalia rosae acyl-CoA Delta(11) desaturase (LOC105687776), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 636 1.4e-64 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 -- -- GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0016021 integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.37978 BP_3 4043.90 190.11 1317 91090326 XP_966482.1 381 5.7e-34 PREDICTED: general transcription factor IIF subunit 1 [Tribolium castaneum]>gi|270013422|gb|EFA09870.1| hypothetical protein TcasGA2_TC012018 [Tribolium castaneum] -- -- -- -- -- K15223 UAF30, SPP27 upstream activation factor subunit UAF30 http://www.genome.jp/dbget-bin/www_bget?ko:K15223 O74503 162 5.8e-10 Upstream activation factor subunit spp27 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=spp27 PE=1 SV=1 PF09726//PF01080//PF04006//PF04147//PF02201 Transmembrane protein//Presenilin//Mpp10 protein//Nop14-like family//SWIB/MDM2 domain GO:0006364 rRNA processing GO:0005515//GO:0003677//GO:0004190 protein binding//DNA binding//aspartic-type endopeptidase activity GO:0032040//GO:0005732//GO:0034457//GO:0016021//GO:0005634 small-subunit processome//small nucleolar ribonucleoprotein complex//Mpp10 complex//integral component of membrane//nucleus KOG1946 RNA polymerase I transcription factor UAF Cluster-8309.37979 BP_3 143.19 4.90 1700 55978158 AAV68692.1 1688 2.0e-185 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q2PQM7 1138 5.0e-123 Chitinase-like protein Idgf4 OS=Glossina morsitans morsitans GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.37980 BP_3 1525.56 17.64 4459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.37981 BP_3 687.00 44.97 1028 332376591 AEE63435.1 1051 9.0e-112 unknown [Dendroctonus ponderosae]>gi|546685738|gb|ERL95193.1| hypothetical protein D910_12461 [Dendroctonus ponderosae] 704269263 XM_010155242.1 100 1.1723e-42 PREDICTED: Eurypyga helias proteasome (prosome, macropain) subunit, alpha type, 6 (PSMA6), transcript variant X2, mRNA K02730 PSMA6 20S proteasome subunit alpha 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02730 Q2YDE4 919 7.5e-98 Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1 PF00227//PF10584 Proteasome subunit//Proteasome subunit A N-terminal signature GO:0006511//GO:0051603 ubiquitin-dependent protein catabolic process//proteolysis involved in cellular protein catabolic process GO:0004175//GO:0004298 endopeptidase activity//threonine-type endopeptidase activity GO:0005839//GO:0019773 proteasome core complex//proteasome core complex, alpha-subunit complex KOG0182 20S proteasome, regulatory subunit alpha type PSMA6/SCL1 Cluster-8309.37982 BP_3 50.36 0.55 4718 254911125 NP_001157183.1 752 1.9e-76 cactus isoform 1 [Tribolium castaneum] -- -- -- -- -- K09259 K09259 ankyrin only family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09259 Q03017 435 4.6e-41 NF-kappa-B inhibitor cactus OS=Drosophila melanogaster GN=cact PE=1 SV=2 PF03279//PF06858//PF13606//PF00023 Bacterial lipid A biosynthesis acyltransferase//Nucleolar GTP-binding protein 1 (NOG1)//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515//GO:0016740//GO:0005525 protein binding//transferase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.37983 BP_3 4072.46 49.53 4255 642928729 XP_008199757.1 2652 8.4e-297 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 746860384 XM_011062730.1 215 5.86736e-106 PREDICTED: Acromyrmex echinatior phosphoenolpyruvate carboxykinase [GTP]-like (LOC105149957), transcript variant X4, mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 2332 4.4e-261 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37984 BP_3 1308.50 57.69 1385 642928729 XP_008199757.1 951 4.8e-100 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 796674999 KP096477.1 103 3.42106e-44 Parapenaeopsis cornuta voucher NTOU-M01863 phosphoenolpyruvate carboxykinase (PEPCK) gene, partial cds K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 827 4.7e-87 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37985 BP_3 105.00 1.95 2893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37986 BP_3 177.32 0.64 13675 642929047 XP_008195667.1 12019 0.0e+00 PREDICTED: baculoviral IAP repeat-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10586 BIRC6, BRUCE baculoviral IAP repeat-containing protein 6 (apollon) http://www.genome.jp/dbget-bin/www_bget?ko:K10586 O88738 2243 3.0e-250 Baculoviral IAP repeat-containing protein 6 OS=Mus musculus GN=Birc6 PE=1 SV=2 PF05743//PF00844//PF12356 UEV domain//Geminivirus coat protein/nuclear export factor BR1 family//Protein of unknown function (DUF3643) GO:0032465//GO:0016567//GO:0006464//GO:0006915//GO:0015031 regulation of cytokinesis//protein ubiquitination//cellular protein modification process//apoptotic process//protein transport GO:0004842//GO:0005198 ubiquitin-protein transferase activity//structural molecule activity GO:0019028 viral capsid KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.37987 BP_3 1496.29 57.96 1536 642931995 XP_008196812.1 1807 2.9e-199 PREDICTED: splicing factor U2AF 50 kDa subunit [Tribolium castaneum]>gi|270011684|gb|EFA08132.1| hypothetical protein TcasGA2_TC005736 [Tribolium castaneum] 642931994 XM_008198590.1 477 0 PREDICTED: Tribolium castaneum splicing factor U2AF 50 kDa subunit (LOC663317), mRNA K12837 U2AF2 splicing factor U2AF 65 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12837 Q24562 1582 1.5e-174 Splicing factor U2AF 50 kDa subunit OS=Drosophila melanogaster GN=U2af50 PE=1 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0000166//GO:0003723//GO:0003676 nucleotide binding//RNA binding//nucleic acid binding GO:0005634 nucleus KOG0120 Splicing factor U2AF, large subunit (RRM superfamily) Cluster-8309.37988 BP_3 53.00 35.82 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37990 BP_3 2369.83 18.64 6420 332375334 AEE62808.1 407 2.7e-36 unknown [Dendroctonus ponderosae]>gi|478257466|gb|ENN77622.1| hypothetical protein YQE_05916, partial [Dendroctonus ponderosae]>gi|546679860|gb|ERL90248.1| hypothetical protein D910_07600 [Dendroctonus ponderosae] 254583399 XM_002497223.1 38 2.19725e-07 Zygosaccharomyces rouxii hypothetical protein (ZYRO0F01650g) mRNA, complete cds K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q9V429 369 2.8e-33 Thioredoxin-2 OS=Drosophila melanogaster GN=Trx-2 PE=1 SV=2 PF00085//PF02966 Thioredoxin//Mitosis protein DIM1 GO:0045454//GO:0000398 cell redox homeostasis//mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex KOG0907 Thioredoxin Cluster-8309.37993 BP_3 40.72 0.38 5487 91087185 XP_975426.1 1285 3.5e-138 PREDICTED: retinol dehydrogenase 12-like [Tribolium castaneum] 462343538 APGK01035351.1 39 5.2188e-08 Dendroctonus ponderosae Seq01035361, whole genome shotgun sequence K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q9VC57 530 5.1e-52 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 PF00515//PF00106//PF13414//PF13176//PF01370//PF07475//PF13181//PF02993//PF13174//PF00056//PF02882//PF12242 Tetratricopeptide repeat//short chain dehydrogenase//TPR repeat//Tetratricopeptide repeat//NAD dependent epimerase/dehydratase family//HPr Serine kinase C-terminal domain//Tetratricopeptide repeat//Minor capsid protein VI//Tetratricopeptide repeat//lactate/malate dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0016310//GO:0055114//GO:0000160//GO:0009396//GO:0046487//GO:0006109 metabolic process//phosphorylation//oxidation-reduction process//phosphorelay signal transduction system//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//regulation of carbohydrate metabolic process GO:0004672//GO:0003824//GO:0005515//GO:0016491//GO:0005524//GO:0050662//GO:0000155//GO:0004488 protein kinase activity//catalytic activity//protein binding//oxidoreductase activity//ATP binding//coenzyme binding//phosphorelay sensor kinase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0009365//GO:0019028 protein histidine kinase complex//viral capsid -- -- Cluster-8309.37995 BP_3 304.61 11.59 1559 478256455 ENN76640.1 1875 3.9e-207 hypothetical protein YQE_06819, partial [Dendroctonus ponderosae]>gi|546684774|gb|ERL94369.1| hypothetical protein D910_11649, partial [Dendroctonus ponderosae] 242009899 XM_002425675.1 83 5.06699e-33 Pediculus humanus corporis heat shock protein 75 kDa, putative, mRNA K09488 TRAP1, HSP75 TNF receptor-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09488 Q9CQN1 1339 2.3e-146 Heat shock protein 75 kDa, mitochondrial OS=Mus musculus GN=Trap1 PE=1 SV=1 PF00183 Hsp90 protein GO:0006950//GO:0006457 response to stress//protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.37996 BP_3 3469.14 43.87 4103 189241229 XP_971878.2 754 9.9e-77 PREDICTED: DNA primase large subunit [Tribolium castaneum]>gi|270013987|gb|EFA10435.1| hypothetical protein TcasGA2_TC012678 [Tribolium castaneum] 820836808 XM_012491581.1 96 8.02127e-40 PREDICTED: Apis florea multiple coagulation factor deficiency protein 2 homolog (LOC100872590), mRNA K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 P33610 622 8.2e-63 DNA primase large subunit OS=Mus musculus GN=Prim2 PE=1 SV=1 PF09606//PF00036//PF03153//PF03133//PF13202//PF13499//PF13833//PF13405//PF04104 ARC105 or Med15 subunit of Mediator complex non-fungal//EF hand//Transcription factor IIA, alpha/beta subunit//Tubulin-tyrosine ligase family//EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//Eukaryotic and archaeal DNA primase, large subunit GO:0006464//GO:0006351//GO:0006357//GO:0006269//GO:0006367 cellular protein modification process//transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//DNA replication, synthesis of RNA primer//transcription initiation from RNA polymerase II promoter GO:0003896//GO:0001104//GO:0005509 DNA primase activity//RNA polymerase II transcription cofactor activity//calcium ion binding GO:0016592//GO:0005657//GO:0005672//GO:0005730 mediator complex//replication fork//transcription factor TFIIA complex//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.37998 BP_3 9222.07 830.42 827 91079965 XP_969696.1 626 1.4e-62 PREDICTED: 60S ribosomal protein L14 [Tribolium castaneum]>gi|270004603|gb|EFA01051.1| hypothetical protein TcasGA2_TC003967 [Tribolium castaneum] -- -- -- -- -- K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 Q95ZE8 422 2.6e-40 60S ribosomal protein L14 OS=Drosophila virilis GN=RpL14 PE=3 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3421 60S ribosomal protein L14 Cluster-8309.37999 BP_3 120.35 0.84 7158 270003134 EEZ99581.1 841 1.4e-86 hypothetical protein TcasGA2_TC001567 [Tribolium castaneum] 642915764 XM_008201849.1 58 1.86834e-18 PREDICTED: Tribolium castaneum zinc finger protein ubi-d4 B-like (LOC655725), mRNA K17770 TOM20 mitochondrial import receptor subunit TOM20 http://www.genome.jp/dbget-bin/www_bget?ko:K17770 A6H7B1 316 4.4e-27 Mitochondrial import receptor subunit TOM20 homolog OS=Bos taurus GN=TOMM20 PE=2 SV=1 PF00684//PF02064 DnaJ central domain//MAS20 protein import receptor GO:0006886//GO:0006605 intracellular protein transport//protein targeting GO:0051082//GO:0031072 unfolded protein binding//heat shock protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG4056 Translocase of outer mitochondrial membrane complex, subunit TOM20 Cluster-8309.38000 BP_3 753.84 39.31 1216 189238710 XP_969341.2 1642 3.1e-180 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 662207554 XM_008479062.1 49 3.12256e-14 PREDICTED: Diaphorina citri trichohyalin-like (LOC103514197), mRNA -- -- -- -- Q9JM99 200 2.1e-14 Proteoglycan 4 OS=Mus musculus GN=Prg4 PE=1 SV=2 PF09036 Bcr-Abl oncoprotein oligomerisation domain GO:0007165//GO:0006468//GO:0009069//GO:0016310 signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005096//GO:0004674 GTPase activator activity//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.38002 BP_3 1850.00 65.46 1654 189235713 XP_968592.2 1071 6.9e-114 PREDICTED: uncharacterized protein LOC657010 [Tribolium castaneum]>gi|270003390|gb|EEZ99837.1| hypothetical protein TcasGA2_TC002618 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38003 BP_3 11.46 0.39 1714 270001943 EEZ98390.1 619 1.9e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 6.40293e-117 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 8.0e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.38004 BP_3 3452.83 32.44 5422 478253683 ENN73984.1 622 2.6e-61 hypothetical protein YQE_09419, partial [Dendroctonus ponderosae]>gi|478266021|gb|ENN82657.1| hypothetical protein YQE_00972, partial [Dendroctonus ponderosae] 617660876 XM_007537263.1 115 2.91201e-50 PREDICTED: Erinaceus europaeus ZFP36 ring finger protein-like 2 (ZFP36L2), mRNA K18753 ZFP36L butyrate response factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18753 P47980 385 3.3e-35 Protein TIS11 OS=Drosophila melanogaster GN=Tis11 PE=2 SV=2 PF00642//PF08352 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Oligopeptide/dipeptide transporter, C-terminal region GO:0015833 peptide transport GO:0046872//GO:0000166//GO:0005524 metal ion binding//nucleotide binding//ATP binding -- -- KOG1677 CCCH-type Zn-finger protein Cluster-8309.38005 BP_3 146.63 5.49 1579 642927514 XP_008195300.1 1575 2.4e-172 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] 645016212 XM_008213163.1 152 2.25696e-71 PREDICTED: Nasonia vitripennis RNA-binding protein fusilli (LOC100120385), transcript variant X2, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 968 2.4e-103 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1365 RNA-binding protein Fusilli, contains RRM domain Cluster-8309.38006 BP_3 912.77 3.18 14125 642930533 XP_008196445.1 4929 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12 [Tribolium castaneum] 642930520 XM_008198217.1 971 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X6, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 4185 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.38007 BP_3 5243.24 108.40 2623 91082539 XP_973726.1 2209 1.2e-245 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 4.7e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF06905//PF08496//PF11965//PF03357 Fas apoptotic inhibitory molecule (FAIM1)//Peptidase family S49 N-terminal//Domain of unknown function (DUF3479)//Snf7 GO:0007034//GO:0015994//GO:0043066 vacuolar transport//chlorophyll metabolic process//negative regulation of apoptotic process GO:0016851//GO:0004252 magnesium chelatase activity//serine-type endopeptidase activity GO:0005886//GO:0010007 plasma membrane//magnesium chelatase complex -- -- Cluster-8309.38010 BP_3 196.34 1.44 6865 91082533 XP_973629.1 1806 1.7e-198 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X1 [Tribolium castaneum]>gi|270007557|gb|EFA04005.1| hypothetical protein TcasGA2_TC014154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 878 2.8e-92 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.38012 BP_3 832.34 11.54 3768 91093228 XP_967462.1 705 4.4e-71 PREDICTED: phosphopantothenoylcysteine decarboxylase [Tribolium castaneum]>gi|270016594|gb|EFA13040.1| hypothetical protein TcasGA2_TC010571 [Tribolium castaneum] -- -- -- -- -- K01598 PPCDC, coaC phosphopantothenoylcysteine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01598 Q8BZB2 574 2.8e-57 Phosphopantothenoylcysteine decarboxylase OS=Mus musculus GN=Ppcdc PE=2 SV=1 PF02569//PF02297//PF05676//PF02441 Pantoate-beta-alanine ligase//Cytochrome oxidase c subunit VIb//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Flavoprotein GO:0008152//GO:0006744//GO:0015940//GO:0006120//GO:0006123//GO:0019482//GO:0015992//GO:0006814//GO:0006118 metabolic process//ubiquinone biosynthetic process//pantothenate biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//mitochondrial electron transport, cytochrome c to oxygen//beta-alanine metabolic process//proton transport//sodium ion transport//obsolete electron transport GO:0003954//GO:0003824//GO:0004129//GO:0004592//GO:0008137 NADH dehydrogenase activity//catalytic activity//cytochrome-c oxidase activity//pantoate-beta-alanine ligase activity//NADH dehydrogenase (ubiquinone) activity GO:0045277//GO:0005739 respiratory chain complex IV//mitochondrion KOG0672 Halotolerance protein HAL3 (contains flavoprotein domain) Cluster-8309.38013 BP_3 1384.00 20.57 3535 270005727 EFA02175.1 1798 7.4e-198 hypothetical protein TcasGA2_TC007831 [Tribolium castaneum] -- -- -- -- -- K03211 ETV6_7, yan ETS translocation variant 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K03211 Q01842 523 2.1e-51 Ets DNA-binding protein pokkuri OS=Drosophila melanogaster GN=aop PE=1 SV=2 PF00178//PF02198 Ets-domain//Sterile alpha motif (SAM)/Pointed domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.38014 BP_3 314.73 21.21 1007 91081323 XP_970047.1 1063 3.6e-113 PREDICTED: uncharacterized oxidoreductase C115.03 [Tribolium castaneum]>gi|270005200|gb|EFA01648.1| hypothetical protein TcasGA2_TC007219 [Tribolium castaneum] -- -- -- -- -- K00010 iolG myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00010 O05389 462 7.2e-45 Uncharacterized oxidoreductase YrbE OS=Bacillus subtilis (strain 168) GN=yrbE PE=3 SV=2 PF01408//PF02894 Oxidoreductase family, NAD-binding Rossmann fold//Oxidoreductase family, C-terminal alpha/beta domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0000166 oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.38015 BP_3 583.68 12.14 2610 189241581 XP_969604.2 2441 1.5e-272 PREDICTED: phosphoinositide 3-kinase adapter protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.4e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0016020//GO:0005801 membrane//cis-Golgi network -- -- Cluster-8309.38016 BP_3 7242.73 43.33 8349 642911235 XP_008199694.1 6755 0.0e+00 PREDICTED: laminin subunit beta-1 [Tribolium castaneum] 198455549 XM_001360008.2 44 1.32184e-10 Drosophila pseudoobscura pseudoobscura GA20347 (Dpse\GA20347), partial mRNA K05636 LAMB1 laminin, beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05636 P11046 4487 0.0e+00 Laminin subunit beta-1 OS=Drosophila melanogaster GN=LanB1 PE=1 SV=4 PF03554//PF05007//PF00089//PF10440//PF00874//PF05384//PF01133 UL73 viral envelope glycoprotein//Mannosyltransferase (PIG-M)//Trypsin//Ubiquitin-binding WIYLD domain//PRD domain//Sensor protein DegS//Enhancer of rudimentary GO:0007049//GO:0006554//GO:0006355//GO:0006508//GO:0006506//GO:0006479//GO:0006221//GO:0007165//GO:0045747 cell cycle//lysine catabolic process//regulation of transcription, DNA-templated//proteolysis//GPI anchor biosynthetic process//protein methylation//pyrimidine nucleotide biosynthetic process//signal transduction//positive regulation of Notch signaling pathway GO:0004252//GO:0016301//GO:0016758//GO:0018024 serine-type endopeptidase activity//kinase activity//transferase activity, transferring hexosyl groups//histone-lysine N-methyltransferase activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0994 Extracellular matrix glycoprotein Laminin subunit beta Cluster-8309.38017 BP_3 986.61 20.85 2573 642910330 XP_970349.3 1091 5.2e-116 PREDICTED: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGE0 671 1.1e-68 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Xenopus tropicalis GN=ogfod3 PE=2 SV=1 PF13640 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.38018 BP_3 379.75 12.43 1764 91091830 XP_967237.1 891 5.5e-93 PREDICTED: leucine-rich repeat protein soc-2 isoform X1 [Tribolium castaneum] 642937372 XM_962144.2 207 6.73504e-102 PREDICTED: Tribolium castaneum death-associated small cytoplasmic leucine-rich protein SCLP (LOC655583), transcript variant X1, mRNA -- -- -- -- Q8CI70 239 9.1e-19 Leucine-rich repeat-containing protein 20 OS=Mus musculus GN=Lrrc20 PE=2 SV=1 PF02052//PF13855//PF00560 Gallidermin//Leucine rich repeat//Leucine Rich Repeat GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0005576 extracellular region -- -- Cluster-8309.38019 BP_3 4116.93 31.38 6616 546675258 ERL86494.1 972 8.4e-102 hypothetical protein D910_03898 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P70478 235 1.0e-17 Adenomatous polyposis coli protein OS=Rattus norvegicus GN=Apc PE=1 SV=1 PF05924//PF04072//PF05923//PF05972 SAMP Motif//Leucine carboxyl methyltransferase//APC cysteine-rich region//APC 15 residue motif GO:0016055//GO:0032259 Wnt signaling pathway//methylation GO:0008168//GO:0008013 methyltransferase activity//beta-catenin binding GO:0016342 catenin complex -- -- Cluster-8309.38022 BP_3 1487.44 25.09 3149 642917834 XP_008191303.1 1003 1.0e-105 PREDICTED: serine/threonine-protein kinase MARK2 isoform X2 [Tribolium castaneum] 602660707 XM_007435954.1 79 1.73139e-30 PREDICTED: Python bivittatus MAP/microtubule affinity-regulating kinase 1 (MARK1), transcript variant X5, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 Q9P0L2 517 9.5e-51 Serine/threonine-protein kinase MARK1 OS=Homo sapiens GN=MARK1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0586 Serine/threonine protein kinase Cluster-8309.38023 BP_3 22.21 0.63 2004 642916360 XP_008190988.1 350 3.4e-30 PREDICTED: protein disulfide-isomerase [Tribolium castaneum]>gi|270004199|gb|EFA00647.1| hypothetical protein TcasGA2_TC003523 [Tribolium castaneum] 687910403 LK979553.1 48 1.87242e-13 Thelazia callipaeda genome assembly T_callipaeda_Ticino ,scaffold TCLT_scaffold0000014 K09580 PDIA1, P4HB protein disulfide-isomerase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K09580 P54399 294 4.3e-25 Protein disulfide-isomerase OS=Drosophila melanogaster GN=Pdi PE=2 SV=1 PF00462//PF00578//PF00085//PF00854 Glutaredoxin//AhpC/TSA family//Thioredoxin//POT family GO:0006118//GO:0045454//GO:0055114//GO:0006810//GO:0006662 obsolete electron transport//cell redox homeostasis//oxidation-reduction process//transport//glycerol ether metabolic process GO:0015035//GO:0016209//GO:0009055//GO:0016491//GO:0016853//GO:0005215 protein disulfide oxidoreductase activity//antioxidant activity//electron carrier activity//oxidoreductase activity//isomerase activity//transporter activity GO:0016020//GO:0005783 membrane//endoplasmic reticulum KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.38024 BP_3 287.00 26.95 805 91093539 XP_966844.1 649 2.9e-65 PREDICTED: short coiled-coil protein homolog [Tribolium castaneum]>gi|270015586|gb|EFA12034.1| hypothetical protein TcasGA2_TC001451 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8NJZ7 271 8.1e-23 Short coiled-coil protein homolog OS=Brugia malayi GN=Bm1_04115 PE=3 SV=1 PF06005//PF02183//PF00170//PF09728//PF08650//PF06156//PF04977 Protein of unknown function (DUF904)//Homeobox associated leucine zipper//bZIP transcription factor//Myosin-like coiled-coil protein//DASH complex subunit Dad4//Protein of unknown function (DUF972)//Septum formation initiator GO:0006355//GO:0008608//GO:0006260//GO:0007049//GO:0043093//GO:0000917 regulation of transcription, DNA-templated//attachment of spindle microtubules to kinetochore//DNA replication//cell cycle//FtsZ-dependent cytokinesis//barrier septum assembly GO:0019905//GO:0043565//GO:0003700 syntaxin binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0072686//GO:0005667//GO:0042729//GO:0005737 mitotic spindle//transcription factor complex//DASH complex//cytoplasm KOG3650 Predicted coiled-coil protein Cluster-8309.38026 BP_3 3995.84 29.41 6840 642938591 XP_008199855.1 4992 0.0e+00 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X4 [Tribolium castaneum] 642938592 XM_008201634.1 1323 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X9, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 P11505 3442 0.0e+00 Plasma membrane calcium-transporting ATPase 1 OS=Rattus norvegicus GN=Atp2b1 PE=2 SV=2 PF12424//PF00122 Plasma membrane calcium transporter ATPase C terminal//E1-E2 ATPase GO:0006816 calcium ion transport GO:0046872//GO:0005388//GO:0000166 metal ion binding//calcium-transporting ATPase activity//nucleotide binding GO:0016529 sarcoplasmic reticulum KOG0204 Calcium transporting ATPase Cluster-8309.38028 BP_3 358.95 7.22 2689 642922869 XP_008200431.1 3132 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] 768439826 XM_011563263.1 40 7.06211e-09 PREDICTED: Plutella xylostella probable multidrug resistance-associated protein lethal(2)03659 (LOC105391726), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1512 3.4e-166 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF00664//PF13304 ABC transporter//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.38031 BP_3 336.00 28.96 851 91080319 XP_974435.1 615 2.7e-61 PREDICTED: 39S ribosomal protein L21, mitochondrial [Tribolium castaneum]>gi|270005606|gb|EFA02054.1| hypothetical protein TcasGA2_TC007683 [Tribolium castaneum] -- -- -- -- -- K02888 RP-L21, MRPL21, rplU large subunit ribosomal protein L21 http://www.genome.jp/dbget-bin/www_bget?ko:K02888 Q2TBS2 274 3.8e-23 39S ribosomal protein L21, mitochondrial OS=Bos taurus GN=MRPL21 PE=1 SV=1 PF00829 Ribosomal prokaryotic L21 protein -- -- -- -- GO:0005622//GO:0005840 intracellular//ribosome KOG1686 Mitochondrial/chloroplast ribosomal L21 protein Cluster-8309.38033 BP_3 252.00 37.80 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38035 BP_3 848.54 9.49 4600 642922737 XP_008193304.1 1814 1.4e-199 PREDICTED: protein RRP5 homolog [Tribolium castaneum] -- -- -- -- -- K14792 RRP5, PDCD11 rRNA biogenesis protein RRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K14792 Q14690 642 4.4e-65 Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3 PF05843//PF00575//PF13374 Suppressor of forked protein (Suf)//S1 RNA binding domain//Tetratricopeptide repeat GO:0006397 mRNA processing GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus KOG1070 rRNA processing protein Rrp5 Cluster-8309.38036 BP_3 556.50 6.05 4728 332374310 AEE62296.1 1023 7.3e-108 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 474 1.4e-45 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF01353 Green fluorescent protein GO:0008218 bioluminescence -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.38038 BP_3 8.30 0.47 1139 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38039 BP_3 39.91 0.55 3815 642933627 XP_008197501.1 1240 4.1e-133 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [Tribolium castaneum] 676386870 XM_009038466.1 51 7.72161e-15 Aureococcus anophagefferens hypothetical protein partial mRNA K01110 PTEN phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN http://www.genome.jp/dbget-bin/www_bget?ko:K01110 P60484 772 3.1e-80 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens GN=PTEN PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0004721//GO:0008138 protein tyrosine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases Cluster-8309.38040 BP_3 1858.43 24.12 4005 642926721 XP_008194985.1 1671 4.5e-183 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 552 1.1e-54 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.38042 BP_3 959.90 22.60 2339 642928668 XP_008199729.1 1726 1.1e-189 PREDICTED: protein daughterless isoform X6 [Tribolium castaneum] 642928667 XM_008201507.1 357 0 PREDICTED: Tribolium castaneum protein daughterless (LOC662057), transcript variant X6, mRNA K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P11420 592 1.4e-59 Protein daughterless OS=Drosophila melanogaster GN=da PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3910 Helix loop helix transcription factor Cluster-8309.38043 BP_3 100.73 1.94 2799 270003153 EEZ99600.1 2599 7.7e-291 hypothetical protein TcasGA2_TC002116 [Tribolium castaneum] 751219340 XM_011164448.1 192 2.34554e-93 PREDICTED: Solenopsis invicta calpain-A-like (LOC105197860), transcript variant X10, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q11002 2129 1.0e-237 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF13202//PF00648//PF13499//PF13405//PF00036//PF13833 EF hand//Calpain family cysteine protease//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair GO:0006508 proteolysis GO:0005509//GO:0004198 calcium ion binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.38045 BP_3 183.69 2.28 4181 332373348 AEE61815.1 1558 5.9e-170 unknown [Dendroctonus ponderosae] 769840408 XM_011633076.1 188 5.8881e-91 PREDICTED: Pogonomyrmex barbatus probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (LOC105423352), transcript variant X2, mRNA K00161 PDHA, pdhA pyruvate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00161 P26268 1220 3.8e-132 Pyruvate dehydrogenase E1 component subunit alpha type II, mitochondrial (Fragment) OS=Ascaris suum PE=2 SV=1 PF13292//PF00676//PF02775//PF09029 1-deoxy-D-xylulose-5-phosphate synthase//Dehydrogenase E1 component//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//5-aminolevulinate synthase presequence GO:0042967//GO:0016114//GO:0006563//GO:0006694//GO:0006778//GO:0006566//GO:0008152//GO:0006544//GO:0006783 acyl-carrier-protein biosynthetic process//terpenoid biosynthetic process//L-serine metabolic process//steroid biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process//metabolic process//glycine metabolic process//heme biosynthetic process GO:0008661//GO:0003870//GO:0030170//GO:0003824//GO:0016624//GO:0030976 1-deoxy-D-xylulose-5-phosphate synthase activity//5-aminolevulinate synthase activity//pyridoxal phosphate binding//catalytic activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//thiamine pyrophosphate binding GO:0005759 mitochondrial matrix KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.38046 BP_3 495.12 13.05 2121 642933063 XP_008197247.1 1689 1.9e-185 PREDICTED: rab GTPase-binding effector protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35551 370 7.1e-34 Rab GTPase-binding effector protein 1 OS=Mus musculus GN=Rabep1 PE=1 SV=2 PF03528 Rabaptin GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0005096//GO:0008083 GTPase activator activity//growth factor activity -- -- KOG0993 Rab5 GTPase effector Rabaptin-5 Cluster-8309.38047 BP_3 13.72 0.44 1790 642922291 XP_008193096.1 1223 1.8e-131 PREDICTED: uncharacterized protein LOC661530 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 189 5.8e-13 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF02270//PF00441//PF13180//PF00595 Transcription initiation factor IIF, beta subunit//Acyl-CoA dehydrogenase, C-terminal domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) GO:0006367//GO:0055114//GO:0006366 transcription initiation from RNA polymerase II promoter//oxidation-reduction process//transcription from RNA polymerase II promoter GO:0016627//GO:0005515 oxidoreductase activity, acting on the CH-CH group of donors//protein binding GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.38048 BP_3 1336.79 34.71 2148 546682240 ERL92201.1 2808 0.0e+00 hypothetical protein D910_09521 [Dendroctonus ponderosae] 195505178 XM_002099356.1 56 7.17599e-18 Drosophila yakuba GE23386 (Dyak\GE23386), partial mRNA K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q9VA73 2280 2.4e-255 Calcium-binding mitochondrial carrier protein Aralar1 OS=Drosophila melanogaster GN=aralar1 PE=2 SV=1 PF13202//PF13405//PF13833//PF00036//PF13499 EF hand//EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.38050 BP_3 8298.97 56.14 7417 642930349 XP_008196359.1 6991 0.0e+00 PREDICTED: protein 4.1 homolog isoform X1 [Tribolium castaneum]>gi|642930351|ref|XP_008196360.1| PREDICTED: protein 4.1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1372 1.6e-149 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 PF16954//PF05902 Haem-transporter, endosomal/lysosomal, haem-responsive gene//4.1 protein C-terminal domain (CTD) GO:0015886 heme transport GO:0015232//GO:0003779//GO:0005198 heme transporter activity//actin binding//structural molecule activity GO:0005856 cytoskeleton KOG3527 Erythrocyte membrane protein 4.1 and related proteins of the ERM family Cluster-8309.38053 BP_3 340.09 15.58 1344 642915369 XP_008190587.1 981 1.5e-103 PREDICTED: facilitated trehalose transporter Tret1-like isoform X1 [Tribolium castaneum]>gi|642915372|ref|XP_008190589.1| PREDICTED: facilitated trehalose transporter Tret1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 356 1.9e-32 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38057 BP_3 188.57 3.04 3277 642912272 XP_008200632.1 796 1.1e-81 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95M17 353 1.0e-31 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00089//PF00704 Trypsin//Glycosyl hydrolases family 18 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004252//GO:0004553 serine-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.38058 BP_3 84.18 1.84 2492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05309 TraE protein GO:0000746 conjugation -- -- -- -- -- -- Cluster-8309.38059 BP_3 1173.69 26.30 2443 642910560 XP_008200266.1 2041 3.4e-226 PREDICTED: beta-arrestin-1 isoform X1 [Tribolium castaneum]>gi|270015096|gb|EFA11544.1| kurtz [Tribolium castaneum] 642910565 XM_967463.3 581 0 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X4, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 Q4R562 1301 9.0e-142 Beta-arrestin-1 OS=Macaca fascicularis GN=ARRB1 PE=2 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.38060 BP_3 43.09 0.59 3833 270001355 EEZ97802.1 3718 0.0e+00 hypothetical protein TcasGA2_TC000164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UI26 2292 1.7e-256 Importin-11 OS=Homo sapiens GN=IPO11 PE=1 SV=1 PF02985//PF03810 HEAT repeat//Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0005515//GO:0008536 protein binding//Ran GTPase binding -- -- KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) Cluster-8309.38061 BP_3 241.21 2.58 4805 189240719 XP_974316.2 3699 0.0e+00 PREDICTED: TBC1 domain family member 9, partial [Tribolium castaneum] 640785773 XM_008050426.1 160 2.48881e-75 PREDICTED: Tarsius syrichta TBC1 domain family, member 9B (with GRAM domain) (TBC1D9B), transcript variant X2, mRNA -- -- -- -- Q6ZT07 2395 2.5e-268 TBC1 domain family member 9 OS=Homo sapiens GN=TBC1D9 PE=2 SV=2 PF13202//PF10637//PF13499//PF00036//PF13833//PF13405 EF hand//Oxoglutarate and iron-dependent oxygenase degradation C-term//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain GO:0055114 oxidation-reduction process GO:0005509//GO:0031418//GO:0016706//GO:0005506 calcium ion binding//L-ascorbic acid binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron ion binding -- -- KOG4347 GTPase-activating protein VRP Cluster-8309.38064 BP_3 73.98 1.07 3613 332373700 AEE61991.1 1125 8.3e-120 unknown [Dendroctonus ponderosae]>gi|478250001|gb|ENN70507.1| hypothetical protein YQE_12683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 698 1.1e-71 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF00282//PF01053//PF01212//PF00155 Pyridoxal-dependent decarboxylase conserved domain//Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II GO:0009058//GO:0019752//GO:0006520 biosynthetic process//carboxylic acid metabolic process//cellular amino acid metabolic process GO:0016831//GO:0030170//GO:0016829 carboxy-lyase activity//pyridoxal phosphate binding//lyase activity -- -- KOG1368 Threonine aldolase Cluster-8309.38066 BP_3 54.00 8.90 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38067 BP_3 78.69 0.66 6000 642915533 XP_008190655.1 1572 2.0e-171 PREDICTED: tyrosine-protein phosphatase non-receptor type 61F isoform X1 [Tribolium castaneum] -- -- -- -- -- K18026 PTPN2, PTPT tyrosine-protein phosphatase non-receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18026 Q9W0G1 859 4.0e-90 Tyrosine-protein phosphatase non-receptor type 61F OS=Drosophila melanogaster GN=Ptp61F PE=1 SV=1 PF03119//PF00102//PF00782//PF03248//PF08043 NAD-dependent DNA ligase C4 zinc finger domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Rer1 family//Xin repeat GO:0006260//GO:0030036//GO:0006281//GO:0006570//GO:0006470 DNA replication//actin cytoskeleton organization//DNA repair//tyrosine metabolic process//protein dephosphorylation GO:0003911//GO:0004725//GO:0003779//GO:0008138 DNA ligase (NAD+) activity//protein tyrosine phosphatase activity//actin binding//protein tyrosine/serine/threonine phosphatase activity GO:0030054//GO:0016021 cell junction//integral component of membrane -- -- Cluster-8309.38069 BP_3 1168.75 7.06 8266 91079889 XP_968047.1 4173 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 7.1333e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 2.5e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF00443//PF00240//PF14560 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin family//Ubiquitin-like domain GO:0016579 protein deubiquitination GO:0036459//GO:0005515 ubiquitinyl hydrolase activity//protein binding -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.38071 BP_3 1974.03 54.14 2049 91087085 XP_974959.1 1262 6.1e-136 PREDICTED: phytepsin [Tribolium castaneum]>gi|270010541|gb|EFA06989.1| hypothetical protein TcasGA2_TC009950 [Tribolium castaneum] -- -- -- -- -- K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 610 1.0e-61 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF00026//PF01186 Eukaryotic aspartyl protease//Lysyl oxidase GO:0006508//GO:0055114 proteolysis//oxidation-reduction process GO:0005507//GO:0004190//GO:0016641 copper ion binding//aspartic-type endopeptidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor -- -- KOG1339 Aspartyl protease Cluster-8309.38073 BP_3 252.95 2.40 5371 332374566 AEE62424.1 835 5.2e-86 unknown [Dendroctonus ponderosae] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 404 2.0e-37 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF01258//PF01853//PF00412 Prokaryotic dksA/traR C4-type zinc finger//MOZ/SAS family//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0016747 zinc ion binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.38074 BP_3 430.63 5.00 4444 91091728 XP_967315.1 1628 4.8e-178 PREDICTED: argininosuccinate synthase [Tribolium castaneum]>gi|270001069|gb|EEZ97516.1| hypothetical protein TcasGA2_TC011361 [Tribolium castaneum] 78496741 CP000153.1 36 1.96348e-06 Sulfurimonas denitrificans DSM 1251, complete genome K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 Q0IFL5 1380 1.1e-150 Argininosuccinate synthase OS=Aedes aegypti GN=AAEL004701 PE=3 SV=1 PF00498//PF00764 FHA domain//Arginosuccinate synthase GO:0006526//GO:0006522//GO:0006531//GO:0006560 arginine biosynthetic process//alanine metabolic process//aspartate metabolic process//proline metabolic process GO:0005524//GO:0004055//GO:0005515 ATP binding//argininosuccinate synthase activity//protein binding -- -- KOG1706 Argininosuccinate synthase Cluster-8309.38078 BP_3 141.09 1.72 4246 91081821 XP_976452.1 605 1.9e-59 PREDICTED: uncharacterized protein LOC663436 isoform X2 [Tribolium castaneum]>gi|270006302|gb|EFA02750.1| hypothetical protein TcasGA2_TC008483 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00822 PMP-22/EMP/MP20/Claudin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38079 BP_3 31.17 0.81 2149 642933037 XP_008197238.1 654 2.0e-65 PREDICTED: troponin C-like [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P15159 435 2.1e-41 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF13499//PF00036//PF13405//PF13833//PF12763//PF13202 EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.38080 BP_3 12.46 0.56 1370 741829289 AJA91071.1 766 1.3e-78 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 483 3.6e-47 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF08127//PF00067 Peptidase family C1 propeptide//Cytochrome P450 GO:0050790//GO:0055114//GO:0006508 regulation of catalytic activity//oxidation-reduction process//proteolysis GO:0020037//GO:0004197//GO:0005506//GO:0016705 heme binding//cysteine-type endopeptidase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.38081 BP_3 215.40 1.98 5541 189242442 XP_001807060.1 1926 1.7e-212 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- K19599 DOME cytokine receptor domeless http://www.genome.jp/dbget-bin/www_bget?ko:K19599 Q9VWE0 423 1.3e-39 Cytokine receptor OS=Drosophila melanogaster GN=dome PE=1 SV=1 PF16794//PF00041 Fibronectin-III type domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38083 BP_3 318.29 1.71 9254 642919915 XP_008192123.1 1677 2.1e-183 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] 462448440 APGK01008686.1 56 3.12823e-17 Dendroctonus ponderosae Seq01008694, whole genome shotgun sequence -- -- -- -- Q7Z6G8 754 9.2e-78 Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Homo sapiens GN=ANKS1B PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38085 BP_3 1493.40 20.66 3776 642914766 XP_008190343.1 639 2.0e-63 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 329 7.2e-29 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38087 BP_3 26.42 0.53 2699 55978158 AAV68692.1 1452 7.5e-158 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q2PQM7 931 8.0e-99 Chitinase-like protein Idgf4 OS=Glossina morsitans morsitans GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.38090 BP_3 68.48 0.82 4313 546676660 ERL87624.1 1073 1.1e-113 hypothetical protein D910_05015 [Dendroctonus ponderosae] -- -- -- -- -- K05642 ABCA2 ATP-binding cassette, subfamily A (ABC1), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05642 P78363 618 2.5e-62 Retinal-specific ATP-binding cassette transporter OS=Homo sapiens GN=ABCA4 PE=1 SV=3 PF01312//PF01225//PF06414//PF13304//PF00005//PF04310//PF03193 FlhB HrpN YscU SpaS Family//Mur ligase family, catalytic domain//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//MukB N-terminal//Protein of unknown function, DUF258 GO:0007059//GO:0009058//GO:0030261//GO:0009306 chromosome segregation//biosynthetic process//chromosome condensation//protein secretion GO:0016887//GO:0016301//GO:0005525//GO:0003677//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//DNA binding//ATP binding//GTPase activity GO:0016020//GO:0009295 membrane//nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.38091 BP_3 14309.34 281.02 2746 91095131 XP_971500.1 2329 1.5e-259 PREDICTED: transforming growth factor-beta-induced protein ig-h3 [Tribolium castaneum]>gi|270015611|gb|EFA12059.1| hypothetical protein TcasGA2_TC012903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15063 555 3.2e-55 Periostin OS=Homo sapiens GN=POSTN PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.38092 BP_3 2.66 0.34 669 270009761 EFA06209.1 641 2.0e-64 hypothetical protein TcasGA2_TC009058 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38094 BP_3 1241.61 13.70 4661 642923453 XP_008193751.1 4355 0.0e+00 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1597 8.2e-176 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF02460//PF00400 Patched family//WD domain, G-beta repeat GO:0007165 signal transduction GO:0008158//GO:0005515 hedgehog receptor activity//protein binding GO:0016020 membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.38097 BP_3 2329.00 50.58 2511 642928704 XP_008199746.1 2413 2.6e-269 PREDICTED: microtubule-actin cross-linking factor 1 isoform X9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UPN3 770 3.5e-80 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens GN=MACF1 PE=1 SV=4 PF13499//PF13833//PF00036//PF13405//PF02187//PF00435 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Growth-Arrest-Specific Protein 2 Domain//Spectrin repeat GO:0007050 cell cycle arrest GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.38099 BP_3 21.43 1.67 911 91090278 XP_970876.1 404 8.4e-37 PREDICTED: cell division control protein 42 homolog [Tribolium castaneum]>gi|270014293|gb|EFA10741.1| hypothetical protein TcasGA2_TC012434 [Tribolium castaneum] -- -- -- -- -- K07866 RHOV, WRCH2 Ras homolog gene family, member V http://www.genome.jp/dbget-bin/www_bget?ko:K07866 Q17QI8 254 8.6e-21 Rho-related GTP-binding protein RhoV OS=Bos taurus GN=Rhov PE=2 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0016020//GO:0005622 membrane//intracellular KOG0393 Ras-related small GTPase, Rho type Cluster-8309.381 BP_3 1.00 0.32 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00424//PF13741 REV protein (anti-repression trans-activator protein)//Mitochondrial ribosomal protein S25 GO:0006355//GO:0042254 regulation of transcription, DNA-templated//ribosome biogenesis GO:0003735//GO:0003700 structural constituent of ribosome//transcription factor activity, sequence-specific DNA binding GO:0005840//GO:0005763//GO:0042025//GO:0005667 ribosome//mitochondrial small ribosomal subunit//host cell nucleus//transcription factor complex -- -- Cluster-8309.3810 BP_3 13.00 0.66 1245 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38100 BP_3 47.48 0.62 4011 91077534 XP_967040.1 750 2.8e-76 PREDICTED: myophilin [Tribolium castaneum]>gi|270001583|gb|EEZ98030.1| hypothetical protein TcasGA2_TC000431 [Tribolium castaneum] 768423547 XM_011554383.1 76 1.0286e-28 PREDICTED: Plutella xylostella muscle-specific protein 20 (LOC105384189), mRNA -- -- -- -- P14318 388 1.1e-35 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain GO:0031032 actomyosin structure organization GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG2046 Calponin Cluster-8309.38101 BP_3 591.04 4.99 5996 642936042 XP_008198279.1 859 9.6e-89 PREDICTED: annexin B9 isoform X2 [Tribolium castaneum] 688710729 LL320824.1 36 2.6548e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0001563 K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 677 5.0e-69 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF04851//PF02562//PF00580//PF06733//PF00191//PF01580//PF00270 Type III restriction enzyme, res subunit//PhoH-like protein//UvrD/REP helicase N-terminal domain//DEAD_2//Annexin//FtsK/SpoIIIE family//DEAD/DEAH box helicase -- -- GO:0003677//GO:0016787//GO:0005524//GO:0003676//GO:0004003//GO:0000166//GO:0005509//GO:0005544 DNA binding//hydrolase activity//ATP binding//nucleic acid binding//ATP-dependent DNA helicase activity//nucleotide binding//calcium ion binding//calcium-dependent phospholipid binding GO:0005657 replication fork KOG0819 Annexin Cluster-8309.38102 BP_3 155.95 1.10 7095 642920612 XP_008192488.1 1042 6.9e-110 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38103 BP_3 112.01 2.30 2641 91080431 XP_968599.1 460 7.8e-43 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38104 BP_3 4.00 0.66 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07533 BRK domain -- -- GO:0016817//GO:0005515 hydrolase activity, acting on acid anhydrides//protein binding -- -- -- -- Cluster-8309.38106 BP_3 9.00 0.38 1434 -- -- -- -- -- 768311754 CP010982.1 1410 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38107 BP_3 34.56 0.32 5482 688589261 XP_009290233.1 275 4.6e-21 PREDICTED: zinc finger and SCAN domain containing 2-like isoform X1 [Danio rerio] 817210508 XM_012425923.1 150 1.02947e-69 PREDICTED: Orussus abietinus uncharacterized LOC105700249 (LOC105700249), mRNA K09203 EGR1 early growth response protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09203 Q99676 246 4.4e-19 Zinc finger protein 184 OS=Homo sapiens GN=ZNF184 PE=1 SV=4 PF03033//PF02892//PF13912//PF13465//PF03868//PF02207//PF05495//PF00096 Glycosyltransferase family 28 N-terminal domain//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Ribosomal protein L6, N-terminal domain//Putative zinc finger in N-recognin (UBR box)//CHY zinc finger//Zinc finger, C2H2 type GO:0030259//GO:0006412//GO:0042254//GO:0005975 lipid glycosylation//translation//ribosome biogenesis//carbohydrate metabolic process GO:0016758//GO:0003677//GO:0003735//GO:0008270//GO:0046872 transferase activity, transferring hexosyl groups//DNA binding//structural constituent of ribosome//zinc ion binding//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.3811 BP_3 13.74 0.55 1504 821475571 XP_012401294.1 625 3.3e-62 PREDICTED: zinc finger protein 260-like [Sarcophilus harrisii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96NI8 587 3.4e-59 Zinc finger protein 570 OS=Homo sapiens GN=ZNF570 PE=2 SV=1 PF13465//PF00096//PF13912//PF02892//PF02325//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//YGGT family//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.38110 BP_3 52.79 0.36 7348 478253903 ENN74195.1 407 3.1e-36 hypothetical protein YQE_09168, partial [Dendroctonus ponderosae]>gi|546674890|gb|ERL86176.1| hypothetical protein D910_03589 [Dendroctonus ponderosae] -- -- -- -- -- K16336 SDC2 syndecan 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16336 P49415 290 4.6e-24 Syndecan OS=Drosophila melanogaster GN=Sdc PE=2 SV=2 PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.38113 BP_3 984.81 3.34 14512 189233641 XP_001814986.1 2409 4.3e-268 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 242018850 XM_002429839.1 113 1.01205e-48 Pediculus humanus corporis nicotinate phosphoribosyltransferase, putative, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2054 2.6e-228 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF01213//PF16622//PF07776//PF13465//PF00096//PF08603//PF02749 Adenylate cyclase associated (CAP) N terminal//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//Adenylate cyclase associated (CAP) C terminal//Quinolinate phosphoribosyl transferase, N-terminal domain GO:0007010 cytoskeleton organization GO:0003779//GO:0046872//GO:0016763//GO:0008270 actin binding//metal ion binding//transferase activity, transferring pentosyl groups//zinc ion binding GO:0005634 nucleus KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.38114 BP_3 898.69 8.69 5274 91080669 XP_975087.1 970 1.1e-101 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 746866518 XM_011066023.1 149 3.5612e-69 PREDICTED: Acromyrmex echinatior vesicle-trafficking protein SEC22b (LOC105152004), transcript variant X3, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 719 6.0e-74 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.38116 BP_3 1096.18 8.29 6667 546676860 ERL87797.1 1674 3.4e-183 hypothetical protein D910_05186 [Dendroctonus ponderosae] 512862182 XM_002935331.2 57 6.25643e-18 PREDICTED: Xenopus (Silurana) tropicalis enhancer of rudimentary homolog (Drosophila) (erh), mRNA -- -- -- -- Q8NBJ9 1125 6.3e-121 SID1 transmembrane family member 2 OS=Homo sapiens GN=SIDT2 PE=1 SV=2 PF08030//PF01133//PF00097//PF00175//PF13965 Ferric reductase NAD binding domain//Enhancer of rudimentary//Zinc finger, C3HC4 type (RING finger)//Oxidoreductase NAD-binding domain//dsRNA-gated channel SID-1 GO:0045747//GO:0006221//GO:0015931//GO:0033227//GO:0055114//GO:0007049 positive regulation of Notch signaling pathway//pyrimidine nucleotide biosynthetic process//nucleobase-containing compound transport//dsRNA transport//oxidation-reduction process//cell cycle GO:0016491//GO:0051033//GO:0046872 oxidoreductase activity//RNA transmembrane transporter activity//metal ion binding GO:0016021 integral component of membrane KOG1766 Enhancer of rudimentary Cluster-8309.38118 BP_3 327.15 7.49 2396 332374950 AEE62616.1 1054 9.4e-112 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 Q86VD7 693 2.8e-71 Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens GN=SLC25A42 PE=2 SV=2 PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0752 Mitochondrial solute carrier protein Cluster-8309.38119 BP_3 143.62 2.24 3386 91091818 XP_966528.1 1854 2.3e-204 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 1223 1.4e-132 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF10613//PF00060//PF03594 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//Benzoate membrane transport protein GO:0006810//GO:0007268//GO:0042919//GO:0007165//GO:0006811 transport//synaptic transmission//benzoate transport//signal transduction//ion transport GO:0004970//GO:0005234//GO:0042925//GO:0005216 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity//benzoate transporter activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.38120 BP_3 5.55 0.39 976 546686048 ERL95448.1 650 2.7e-65 hypothetical protein D910_12710, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZLD7 397 2.4e-37 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.38121 BP_3 112.37 0.56 9914 91085247 XP_973234.1 3384 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 315 3.53206e-161 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 2219 1.3e-247 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF11698//PF05997//PF02985//PF00015//PF08064//PF07690//PF00083//PF06009//PF14372 V-ATPase subunit H//Nucleolar protein,Nop52//HEAT repeat//Methyl-accepting chemotaxis protein (MCP) signalling domain//UME (NUC010) domain//Major Facilitator Superfamily//Sugar (and other) transporter//Laminin Domain II//Domain of unknown function (DUF4413) GO:0007155//GO:0016310//GO:0015991//GO:0006364//GO:0009069//GO:0055085//GO:0007165 cell adhesion//phosphorylation//ATP hydrolysis coupled proton transport//rRNA processing//serine family amino acid metabolic process//transmembrane transport//signal transduction GO:0004871//GO:0005515//GO:0016820//GO:0022857//GO:0003677//GO:0004674 signal transducer activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//transmembrane transporter activity//DNA binding//protein serine/threonine kinase activity GO:0016020//GO:0000221//GO:0016021//GO:0030688 membrane//vacuolar proton-transporting V-type ATPase, V1 domain//integral component of membrane//preribosome, small subunit precursor KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.38123 BP_3 965.00 27.32 1994 642923056 XP_008200513.1 1026 1.4e-108 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X4 [Tribolium castaneum]>gi|270006595|gb|EFA03043.1| hypothetical protein TcasGA2_TC010469 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H6 574 1.5e-57 Fibronectin type-III domain-containing protein 3A OS=Homo sapiens GN=FNDC3A PE=1 SV=4 PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.38124 BP_3 284.84 2.63 5518 642918063 XP_008193852.1 4540 0.0e+00 PREDICTED: nucleoprotein TPR isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z8P9 1544 1.4e-169 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07926//PF02186//PF05294//PF06005//PF07544 TPR/MLP1/MLP2-like protein//TFIIE beta subunit core domain//Scorpion short toxin//Protein of unknown function (DUF904)//RNA polymerase II transcription mediator complex subunit 9 GO:0006357//GO:0006606//GO:0006367//GO:0043093//GO:0000917//GO:0009405 regulation of transcription from RNA polymerase II promoter//protein import into nucleus//transcription initiation from RNA polymerase II promoter//FtsZ-dependent cytokinesis//barrier septum assembly//pathogenesis GO:0001104 RNA polymerase II transcription cofactor activity GO:0005576//GO:0005737//GO:0016592 extracellular region//cytoplasm//mediator complex KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.38127 BP_3 232.19 1.97 5986 91089945 XP_973312.1 588 2.6e-57 PREDICTED: eukaryotic translation initiation factor 3 subunit A [Tribolium castaneum]>gi|270013675|gb|EFA10123.1| hypothetical protein TcasGA2_TC012303 [Tribolium castaneum] 642933533 XM_008199237.1 55 7.26541e-17 PREDICTED: Tribolium castaneum protein alan shepard (LOC663083), transcript variant X7, mRNA K03254 EIF3A translation initiation factor 3 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03254 B4QVI2 409 6.0e-38 Eukaryotic translation initiation factor 3 subunit A OS=Drosophila simulans GN=eIF3-S10 PE=3 SV=1 PF02983 Alpha-lytic protease prodomain GO:0006508//GO:0006413//GO:0006446 proteolysis//translational initiation//regulation of translational initiation GO:0003743//GO:0008236 translation initiation factor activity//serine-type peptidase activity GO:0005576//GO:0005840 extracellular region//ribosome KOG2072 Translation initiation factor 3, subunit a (eIF-3a) Cluster-8309.38129 BP_3 175.85 2.65 3495 91089945 XP_973312.1 3473 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit A [Tribolium castaneum]>gi|270013675|gb|EFA10123.1| hypothetical protein TcasGA2_TC012303 [Tribolium castaneum] -- -- -- -- -- K03254 EIF3A translation initiation factor 3 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03254 Q173M7 2783 0.0e+00 Eukaryotic translation initiation factor 3 subunit A OS=Aedes aegypti GN=eIF3-S10 PE=3 SV=1 PF01399 PCI domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743//GO:0005515 translation initiation factor activity//protein binding GO:0005840 ribosome KOG2072 Translation initiation factor 3, subunit a (eIF-3a) Cluster-8309.38130 BP_3 221.40 16.26 948 642912644 XP_008200947.1 466 5.7e-44 PREDICTED: uncharacterized protein LOC103315046 isoform X1 [Tribolium castaneum]>gi|270002621|gb|EEZ99068.1| hypothetical protein TcasGA2_TC004945 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00170//PF07716//PF13631//PF01253//PF05791 bZIP transcription factor//Basic region leucine zipper//Cytochrome b(N-terminal)/b6/petB//Translation initiation factor SUI1//Bacillus haemolytic enterotoxin (HBL) GO:0006446//GO:0009405//GO:0006355//GO:0006118//GO:0006413 regulation of translational initiation//pathogenesis//regulation of transcription, DNA-templated//obsolete electron transport//translational initiation GO:0016491//GO:0003743//GO:0003700//GO:0043565//GO:0009055 oxidoreductase activity//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//electron carrier activity GO:0005667//GO:0005840//GO:0016020 transcription factor complex//ribosome//membrane -- -- Cluster-8309.38131 BP_3 29.99 0.56 2856 642919248 XP_008191793.1 999 2.7e-105 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|642919250|ref|XP_008191794.1| PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|270005765|gb|EFA02213.1| hypothetical protein TcasGA2_TC007872 [Tribolium castaneum] 170068618 XM_001868902.1 84 2.60604e-33 Culex quinquefasciatus cation efflux protein/ zinc transporter, mRNA K14688 SLC30A1, ZNT1 solute carrier family 30 (zinc transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14688 Q60738 372 5.6e-34 Zinc transporter 1 OS=Mus musculus GN=Slc30a1 PE=1 SV=1 PF01545 Cation efflux family GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.38132 BP_3 2886.60 60.96 2574 91083819 XP_973530.1 2792 0.0e+00 PREDICTED: trifunctional enzyme subunit alpha, mitochondrial [Tribolium castaneum] 689427973 LL903388.1 36 1.13132e-06 Schistocephalus solidus genome assembly S_solidus_NST_G2 ,scaffold SSLN_scaffold0003160 K07515 HADHA enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07515 P40939 1971 1.9e-219 Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2 PF03446//PF02737//PF02529//PF02609//PF16113//PF00378//PF01048//PF00725 NAD binding domain of 6-phosphogluconate dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Cytochrome B6-F complex subunit 5//Exonuclease VII small subunit//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//Phosphorylase superfamily//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GO:0006552//GO:0006308//GO:0006631//GO:0006633//GO:0006098//GO:0018874//GO:0008152//GO:0006554//GO:0055114//GO:0019521//GO:0006568//GO:0009116//GO:0006574//GO:0006550 leucine catabolic process//DNA catabolic process//fatty acid metabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//metabolic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process//nucleoside metabolic process//valine catabolic process//isoleucine catabolic process GO:0016491//GO:0008855//GO:0016836//GO:0003824//GO:0003857//GO:0004616 oxidoreductase activity//exodeoxyribonuclease VII activity//hydro-lyase activity//catalytic activity//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity GO:0009512//GO:0009318 cytochrome b6f complex//exodeoxyribonuclease VII complex KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.38135 BP_3 9988.37 358.94 1633 264667329 ACY71250.1 499 1.5e-47 ribosomal protein L24 [Chrysomela tremula] 40642995 AJ563459.1 48 1.51962e-13 Crassostrea gigas partial mRNA for ribosomal protein L24 (rpl24 gene) K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q6F444 444 1.4e-42 60S ribosomal protein L24 OS=Plutella xylostella GN=RpL24 PE=2 SV=1 PF07565//PF11808 Band 3 cytoplasmic domain//Domain of unknown function (DUF3329) GO:0006820//GO:0016310 anion transport//phosphorylation GO:0004673//GO:0008509 protein histidine kinase activity//anion transmembrane transporter activity GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex KOG1722 60s ribosomal protein L24 Cluster-8309.38136 BP_3 989.79 17.41 3032 91089929 XP_973045.1 210 8.8e-14 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168 Triple QxxK/R motif-containing protein family -- -- -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.38137 BP_3 156.32 2.11 3862 189237166 XP_974303.2 1146 3.3e-122 PREDICTED: transmembrane protein 198 isoform X1 [Tribolium castaneum]>gi|270007195|gb|EFA03643.1| hypothetical protein TcasGA2_TC013737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q498W5 470 3.3e-45 Transmembrane protein 198-B OS=Danio rerio GN=tmem198b PE=2 SV=1 PF05365//PF09207 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Yeast killer toxin GO:0008219//GO:0009405//GO:0006122 cell death//pathogenesis//mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005743//GO:0005576 mitochondrial respiratory chain complex III//mitochondrial inner membrane//extracellular region -- -- Cluster-8309.38138 BP_3 4603.42 47.36 4977 270008215 EFA04663.1 163 4.1e-08 chickadee [Tribolium castaneum] 282165793 NM_001170665.1 110 1.60778e-47 Tribolium castaneum chickadee (chic), mRNA -- -- -- -- P25843 159 4.9e-09 Profilin OS=Drosophila melanogaster GN=chic PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38140 BP_3 81.82 1.30 3323 91077504 XP_966852.1 2795 0.0e+00 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P26779 409 3.3e-38 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF05184//PF02627 Saposin-like type B, region 1//Carboxymuconolactone decarboxylase family GO:0006629//GO:0055114 lipid metabolic process//oxidation-reduction process GO:0051920 peroxiredoxin activity -- -- -- -- Cluster-8309.38142 BP_3 1.00 3.39 276 478253268 ENN73639.1 280 6.0e-23 hypothetical protein YQE_09885, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35554 210 3.3e-16 Flightin OS=Drosophila melanogaster GN=fln PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38147 BP_3 2330.12 44.49 2816 270015414 EFA11862.1 1358 6.2e-147 hypothetical protein TcasGA2_TC005104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38150 BP_3 98.62 1.67 3143 91086995 XP_973636.1 1879 2.7e-207 PREDICTED: protein krasavietz [Tribolium castaneum] 642929327 XM_968543.2 521 0 PREDICTED: Tribolium castaneum protein krasavietz (LOC662449), mRNA -- -- -- -- Q9VNE2 1321 5.6e-144 Protein krasavietz OS=Drosophila melanogaster GN=kra PE=1 SV=1 PF02020 eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515 protein binding -- -- KOG2297 Predicted translation factor, contains W2 domain Cluster-8309.38151 BP_3 1139.78 14.16 4172 478251554 ENN72016.1 1206 3.9e-129 hypothetical protein YQE_11307, partial [Dendroctonus ponderosae]>gi|546681219|gb|ERL91354.1| hypothetical protein D910_08686 [Dendroctonus ponderosae] -- -- -- -- -- K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00898 P91622 860 2.1e-90 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 PF01745 Isopentenyl transferase GO:0016114//GO:0006694//GO:0009058 terpenoid biosynthetic process//steroid biosynthetic process//biosynthetic process GO:0004161 dimethylallyltranstransferase activity -- -- KOG0787 Dehydrogenase kinase Cluster-8309.38152 BP_3 129.83 15.44 697 642927179 XP_008195168.1 544 3.8e-53 PREDICTED: dihydrofolate reductase [Tribolium castaneum] 389612312 AK403254.1 35 1.06284e-06 Papilio xuthus mRNA for dihydrofolate reductase, partial cds, sequence id: Px-1353, expressed in epidermis K00287 folA dihydrofolate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00287 Q9U8B8 387 2.5e-36 Dihydrofolate reductase OS=Heliothis virescens GN=DHFR PE=1 SV=1 PF00186 Dihydrofolate reductase GO:0006761//GO:0046656//GO:0009165//GO:0055114//GO:0006545 dihydrofolate biosynthetic process//folic acid biosynthetic process//nucleotide biosynthetic process//oxidation-reduction process//glycine biosynthetic process GO:0004146 dihydrofolate reductase activity -- -- KOG1324 Dihydrofolate reductase Cluster-8309.38153 BP_3 44.94 1.46 1777 642928571 XP_008199962.1 540 2.8e-52 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q16MW6 517 5.3e-51 S-methyl-5'-thioadenosine phosphorylase OS=Aedes aegypti GN=AAEL012172 PE=3 SV=1 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.38154 BP_3 3433.42 19.62 8725 91090139 XP_971650.1 2671 1.1e-298 PREDICTED: WEB family protein At3g02930, chloroplastic [Tribolium castaneum]>gi|270013743|gb|EFA10191.1| hypothetical protein TcasGA2_TC012383 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38155 BP_3 606.89 15.68 2157 546679644 ERL90075.1 1983 1.6e-219 hypothetical protein D910_07430, partial [Dendroctonus ponderosae] 815900771 XM_012381089.1 91 2.51962e-37 PREDICTED: Bombus impatiens lateral signaling target protein 2 homolog (LOC100747478), transcript variant X2, mRNA -- -- -- -- B4M140 1060 7.0e-114 Lateral signaling target protein 2 homolog OS=Drosophila virilis GN=GJ23073 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1819 FYVE finger-containing proteins Cluster-8309.38156 BP_3 70.57 3.70 1212 91091522 XP_969887.1 335 1.1e-28 PREDICTED: frataxin homolog, mitochondrial [Tribolium castaneum]>gi|270001018|gb|EEZ97465.1| hypothetical protein TcasGA2_TC011296 [Tribolium castaneum] -- -- -- -- -- K19054 FXN frataxin http://www.genome.jp/dbget-bin/www_bget?ko:K19054 Q9W385 293 3.4e-25 Frataxin homolog, mitochondrial OS=Drosophila melanogaster GN=fh PE=2 SV=1 PF01491 Frataxin-like domain GO:0016226 iron-sulfur cluster assembly GO:0008199 ferric iron binding -- -- KOG3413 Mitochondrial matrix protein frataxin, involved in Fe/S protein biosynthesis Cluster-8309.38157 BP_3 165.75 0.72 11462 91083299 XP_974608.1 2229 2.5e-247 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 2.8e-193 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 PF06414//PF01695//PF11057//PF06309//PF00004 Zeta toxin//IstB-like ATP binding protein//Cortexin of kidney//Torsin//ATPase family associated with various cellular activities (AAA) -- -- GO:0016301//GO:0005524 kinase activity//ATP binding GO:0031224 intrinsic component of membrane KOG2558 Negative regulator of histones Cluster-8309.38158 BP_3 1242.96 8.67 7203 646710887 KDR16277.1 5755 0.0e+00 Myosin-XVIIIa, partial [Zootermopsis nevadensis] 817181759 XM_012425868.1 44 1.13959e-10 PREDICTED: Orussus abietinus unconventional myosin-XVIIIa (LOC105699960), transcript variant X6, mRNA K10362 MYO18 myosin XVIII http://www.genome.jp/dbget-bin/www_bget?ko:K10362 Q92614 3238 0.0e+00 Unconventional myosin-XVIIIa OS=Homo sapiens GN=MYO18A PE=1 SV=3 PF01576//PF00063//PF00612//PF00595//PF01213//PF13180//PF01418//PF00005 Myosin tail//Myosin head (motor domain)//IQ calmodulin-binding motif//PDZ domain (Also known as DHR or GLGF)//Adenylate cyclase associated (CAP) N terminal//PDZ domain//Helix-turn-helix domain, rpiR family//ABC transporter GO:0006355//GO:0007010 regulation of transcription, DNA-templated//cytoskeleton organization GO:0003774//GO:0016887//GO:0003700//GO:0005524//GO:0005515//GO:0003779 motor activity//ATPase activity//transcription factor activity, sequence-specific DNA binding//ATP binding//protein binding//actin binding GO:0016459//GO:0005667 myosin complex//transcription factor complex KOG0161 Myosin class II heavy chain Cluster-8309.38160 BP_3 59.41 1.13 2823 91078460 XP_967570.1 1148 1.4e-122 PREDICTED: tether containing UBX domain for GLUT4-like [Tribolium castaneum] -- -- -- -- -- K15627 ASPSCR1, ASPL tether containing UBX domain for GLUT4 http://www.genome.jp/dbget-bin/www_bget?ko:K15627 Q9BZE9 487 2.6e-47 Tether containing UBX domain for GLUT4 OS=Homo sapiens GN=ASPSCR1 PE=1 SV=1 PF00789//PF02196 UBX domain//Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057//GO:0005515 receptor signaling protein activity//protein binding -- -- KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.38161 BP_3 20.08 1.19 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38162 BP_3 59.44 0.39 7593 91090366 XP_968305.1 2229 1.7e-247 PREDICTED: T-cell immunomodulatory protein [Tribolium castaneum]>gi|270013408|gb|EFA09856.1| hypothetical protein TcasGA2_TC012004 [Tribolium castaneum] 765338960 XM_011495191.1 147 6.64325e-68 Aedes aegypti AAEL017098-RA partial mRNA K17257 ITFG1 integrin alpha FG-GAP repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17257 P18459 1010 1.6e-107 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00351//PF00140 Biopterin-dependent aromatic amino acid hydroxylase//Sigma-70 factor, region 1.2 GO:0006355//GO:0006352//GO:0055114 regulation of transcription, DNA-templated//DNA-templated transcription, initiation//oxidation-reduction process GO:0003677//GO:0016714//GO:0016987//GO:0003700 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3820 Aromatic amino acid hydroxylase Cluster-8309.38163 BP_3 764.81 6.15 6282 546673472 ERL85070.1 2710 2.3e-303 hypothetical protein D910_02493 [Dendroctonus ponderosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 Q27772 2373 1.1e-265 C-1-tetrahydrofolate synthase, cytoplasmic OS=Spodoptera frugiperda PE=2 SV=3 PF01268//PF05175//PF01795//PF01189//PF09445 Formate--tetrahydrofolate ligase//Methyltransferase small domain//MraW methylase family//16S rRNA methyltransferase RsmF//RNA cap guanine-N2 methyltransferase GO:0009396//GO:0046487//GO:0009452//GO:0001510 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//7-methylguanosine RNA capping//RNA methylation GO:0005524//GO:0008168//GO:0004329 ATP binding//methyltransferase activity//formate-tetrahydrofolate ligase activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.38164 BP_3 11.43 1.20 750 478252441 ENN72864.1 297 1.8e-24 hypothetical protein YQE_10513, partial [Dendroctonus ponderosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 O96553 234 1.5e-18 C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster GN=pug PE=1 SV=4 PF01268 Formate--tetrahydrofolate ligase GO:0046487//GO:0009396 glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0004329//GO:0005524 formate-tetrahydrofolate ligase activity//ATP binding -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.38168 BP_3 217.49 3.14 3627 642936487 XP_008198457.1 2312 1.9e-257 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.44737e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1216 9.6e-132 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF05699//PF01699//PF10613//PF00060 hAT family C-terminal dimerisation region//Sodium/calcium exchanger protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006811//GO:0055085//GO:0007165//GO:0007268 ion transport//transmembrane transport//signal transduction//synaptic transmission GO:0005216//GO:0004970//GO:0005234//GO:0046983 ion channel activity//ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity//protein dimerization activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.38173 BP_3 12.21 1.11 821 332375664 AEE62973.1 174 3.5e-10 unknown [Dendroctonus ponderosae]>gi|478254613|gb|ENN74856.1| hypothetical protein YQE_08626, partial [Dendroctonus ponderosae]>gi|546673364|gb|ERL84987.1| hypothetical protein D910_02410 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZC48 125 7.0e-06 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38174 BP_3 4.67 0.58 677 195438349 XP_002067099.1 182 3.5e-11 GK24813 [Drosophila willistoni]>gi|194163184|gb|EDW78085.1| GK24813 [Drosophila willistoni] -- -- -- -- -- K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00507 155 1.9e-09 Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2 -- -- GO:0015976//GO:0009094//GO:0006522//GO:0000162//GO:0006520//GO:0009821//GO:0006531//GO:0006560//GO:0006571//GO:0009058//GO:0006525//GO:0006107//GO:0006536//GO:0006534 carbon utilization//L-phenylalanine biosynthetic process//alanine metabolic process//tryptophan biosynthetic process//cellular amino acid metabolic process//alkaloid biosynthetic process//aspartate metabolic process//proline metabolic process//tyrosine biosynthetic process//biosynthetic process//arginine metabolic process//oxaloacetate metabolic process//glutamate metabolic process//cysteine metabolic process GO:0030170//GO:0080130//GO:0004069 pyridoxal phosphate binding//L-phenylalanine:2-oxoglutarate aminotransferase activity//L-aspartate:2-oxoglutarate aminotransferase activity -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.38175 BP_3 1369.07 39.58 1959 646701112 KDR10996.1 1681 1.5e-184 Aspartate aminotransferase, mitochondrial [Zootermopsis nevadensis] 170040613 XM_001848036.1 108 8.10115e-47 Culex quinquefasciatus aspartate aminotransferase, mRNA K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00507 1532 1.2e-168 Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.38176 BP_3 16.32 0.48 1947 332372484 AEE61384.1 1870 1.8e-206 unknown [Dendroctonus ponderosae]>gi|478263185|gb|ENN81578.1| hypothetical protein YQE_02107, partial [Dendroctonus ponderosae]>gi|546681813|gb|ERL91839.1| hypothetical protein D910_09164 [Dendroctonus ponderosae] 170040613 XM_001848036.1 79 1.06375e-30 Culex quinquefasciatus aspartate aminotransferase, mRNA K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00507 1492 5.1e-164 Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.38177 BP_3 109.95 2.06 2858 478252874 ENN73263.1 344 2.4e-29 hypothetical protein YQE_10158, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VBV3 190 7.1e-13 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38179 BP_3 286.00 6.93 2282 91086399 XP_974859.1 2065 5.3e-229 PREDICTED: 26S protease regulatory subunit 4 [Tribolium castaneum]>gi|270010293|gb|EFA06741.1| hypothetical protein TcasGA2_TC009675 [Tribolium castaneum] 829812394 XM_012773957.1 384 0 PREDICTED: Microcebus murinus proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1), mRNA K03062 PSMC1, RPT2 26S proteasome regulatory subunit T2 http://www.genome.jp/dbget-bin/www_bget?ko:K03062 P48601 1995 2.8e-222 26S protease regulatory subunit 4 OS=Drosophila melanogaster GN=Rpt2 PE=1 SV=2 PF00910//PF00931//PF02562//PF02367//PF00005//PF07726//PF07724//PF00004//PF01057//PF05496//PF00158//PF06068//PF01695//PF07728 RNA helicase//NB-ARC domain//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily) GO:0030163//GO:0006310//GO:0002949//GO:0006355//GO:0006281//GO:0019079 protein catabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair//viral genome replication GO:0003724//GO:0017111//GO:0009378//GO:0043531//GO:0003723//GO:0003678//GO:0016887//GO:0008134//GO:0005524 RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//ADP binding//RNA binding//DNA helicase activity//ATPase activity//transcription factor binding//ATP binding GO:0005667//GO:0005657//GO:0005737//GO:0009379 transcription factor complex//replication fork//cytoplasm//Holliday junction helicase complex KOG0726 26S proteasome regulatory complex, ATPase RPT2 Cluster-8309.38180 BP_3 470.02 9.22 2750 91077014 XP_966444.1 1721 4.9e-189 PREDICTED: myc box-dependent-interacting protein 1 isoform X1 [Tribolium castaneum] 817188757 XM_012433541.1 206 3.80115e-101 PREDICTED: Orussus abietinus amphiphysin (LOC105704379), transcript variant X2, mRNA K12562 AMPH amphiphysin http://www.genome.jp/dbget-bin/www_bget?ko:K12562 P50478 529 3.4e-52 Amphiphysin OS=Gallus gallus GN=AMPH PE=2 SV=1 PF02255//PF06456//PF03114//PF14604//PF00018 PTS system, Lactose/Cellobiose specific IIA subunit//Arfaptin-like domain//BAR domain//Variant SH3 domain//SH3 domain GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0019904 protein binding//protein domain specific binding GO:0005737 cytoplasm KOG3771 Amphiphysin Cluster-8309.38181 BP_3 1.00 0.82 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38182 BP_3 830.12 29.24 1660 91080341 XP_974659.1 1374 5.1e-149 PREDICTED: ADP-ribosylation factor GTPase-activating protein 2 [Tribolium castaneum]>gi|270005715|gb|EFA02163.1| hypothetical protein TcasGA2_TC007817 [Tribolium castaneum] -- -- -- -- -- K12493 ARFGAP2_3 ADP-ribosylation factor GTPase-activating protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12493 Q4R4C9 788 1.9e-82 ADP-ribosylation factor GTPase-activating protein 3 OS=Macaca fascicularis GN=ARFGAP3 PE=2 SV=1 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0706 Predicted GTPase-activating protein Cluster-8309.38184 BP_3 1494.47 48.40 1780 91090188 XP_966752.1 1341 3.7e-145 PREDICTED: tetraspanin-33 [Tribolium castaneum]>gi|270013472|gb|EFA09920.1| hypothetical protein TcasGA2_TC012071 [Tribolium castaneum] -- -- -- -- -- K17346 TSPAN33 tetraspanin-33 http://www.genome.jp/dbget-bin/www_bget?ko:K17346 Q8R3S2 559 7.2e-56 Tetraspanin-33 OS=Mus musculus GN=Tspan33 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.38186 BP_3 146.71 1.39 5396 642925975 XP_967431.2 283 5.4e-22 PREDICTED: uncharacterized protein LOC655776 [Tribolium castaneum] -- -- -- -- -- K17558 PPP1R15B, CREP protein phosphatase 1 regulatory subunit 15B http://www.genome.jp/dbget-bin/www_bget?ko:K17558 Q2KI51 135 3.2e-06 Protein phosphatase 1 regulatory subunit 15A OS=Bos taurus GN=PPP1R15A PE=2 SV=2 PF11403 Yeast metallothionein GO:0010273//GO:0071585 detoxification of copper ion//detoxification of cadmium ion GO:0005507//GO:0046870 copper ion binding//cadmium ion binding -- -- -- -- Cluster-8309.38187 BP_3 71.88 0.68 5382 642925975 XP_967431.2 283 5.3e-22 PREDICTED: uncharacterized protein LOC655776 [Tribolium castaneum] -- -- -- -- -- K17558 PPP1R15B, CREP protein phosphatase 1 regulatory subunit 15B http://www.genome.jp/dbget-bin/www_bget?ko:K17558 Q2KI51 135 3.2e-06 Protein phosphatase 1 regulatory subunit 15A OS=Bos taurus GN=PPP1R15A PE=2 SV=2 PF11403 Yeast metallothionein GO:0071585//GO:0010273 detoxification of cadmium ion//detoxification of copper ion GO:0005507//GO:0046870 copper ion binding//cadmium ion binding -- -- -- -- Cluster-8309.38189 BP_3 2041.60 15.34 6708 642935636 XP_008198092.1 5460 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 5.3498e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.0e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF13180//PF00620//PF00595 Glycolipid transfer protein (GLTP)//PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF) GO:0046836//GO:0007165 glycolipid transport//signal transduction GO:0005515//GO:0051861//GO:0017089 protein binding//glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.38191 BP_3 287.73 4.53 3355 91087179 XP_975411.1 767 2.5e-78 PREDICTED: flavin reductase (NADPH) [Tribolium castaneum]>gi|270010563|gb|EFA07011.1| hypothetical protein TcasGA2_TC009981 [Tribolium castaneum] -- -- -- -- -- K05901 BLVRB biliverdin reductase / flavin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K05901 P52556 382 4.5e-35 Flavin reductase (NADPH) OS=Bos taurus GN=BLVRB PE=1 SV=2 PF13508//PF00583//PF13302//PF13673 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0000166 N-acetyltransferase activity//nucleotide binding -- -- KOG3397 Acetyltransferases Cluster-8309.38192 BP_3 109.75 0.89 6217 91077030 XP_967400.1 1924 3.2e-212 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1115 8.5e-120 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF03709//PF07714//PF05028//PF03604//PF00069//PF01029//PF06293 Orn/Lys/Arg decarboxylase, N-terminal domain//Protein tyrosine kinase//Poly (ADP-ribose) glycohydrolase (PARG)//DNA directed RNA polymerase, 7 kDa subunit//Protein kinase domain//NusB family//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0005975//GO:0006355//GO:0006144//GO:0006351//GO:0006206 protein phosphorylation//carbohydrate metabolic process//regulation of transcription, DNA-templated//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0005524//GO:0003899//GO:0016831//GO:0003723//GO:0003677//GO:0004649//GO:0004672//GO:0016773 ATP binding//DNA-directed RNA polymerase activity//carboxy-lyase activity//RNA binding//DNA binding//poly(ADP-ribose) glycohydrolase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0005730//GO:0016020 nucleolus//membrane KOG3087 Serine/threonine protein kinase Cluster-8309.38193 BP_3 230.00 16.06 982 91089443 XP_967760.1 702 2.5e-71 PREDICTED: protein transport protein SFT2 [Tribolium castaneum]>gi|270012564|gb|EFA09012.1| hypothetical protein TcasGA2_TC006720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P6K1 175 1.3e-11 Protein transport protein sft2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sft2 PE=3 SV=1 PF05371//PF04178 Phage major coat protein, Gp8//Got1/Sft2-like family GO:0016192 vesicle-mediated transport -- -- GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG2887 Membrane protein involved in ER to Golgi transport Cluster-8309.38195 BP_3 77.52 0.81 4909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.38199 BP_3 528.79 5.24 5153 642923911 XP_008193924.1 2383 1.6e-265 PREDICTED: nucleolar protein 10 [Tribolium castaneum]>gi|270007790|gb|EFA04238.1| hypothetical protein TcasGA2_TC014492 [Tribolium castaneum] 817185075 XM_012429433.1 112 1.28716e-48 PREDICTED: Orussus abietinus nucleolar protein 10 (LOC105702116), transcript variant X1, mRNA K14788 NOL10, ENP2 ribosome biogenesis protein ENP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14788 Q7T0Q5 1808 3.1e-200 Nucleolar protein 10 OS=Xenopus laevis GN=nol10 PE=2 SV=1 PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus KOG2321 WD40 repeat protein Cluster-8309.38203 BP_3 3692.80 55.24 3514 91091500 XP_968802.1 950 1.6e-99 PREDICTED: GTP-binding protein SAR1b [Tribolium castaneum]>gi|270001011|gb|EEZ97458.1| hypothetical protein TcasGA2_TC011289 [Tribolium castaneum] 755868190 XM_005181111.2 172 3.87375e-82 PREDICTED: Musca domestica GTP-binding protein SAR1b (LOC101900022), mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q9CQC9 750 1.0e-77 GTP-binding protein SAR1b OS=Mus musculus GN=Sar1b PE=1 SV=1 PF00025//PF08477//PF01926//PF00503//PF05493//PF06858//PF10662//PF00071//PF04670 ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//G-protein alpha subunit//ATP synthase subunit H//Nucleolar GTP-binding protein 1 (NOG1)//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region GO:0015992//GO:0007186//GO:0006886//GO:0016192//GO:0007165//GO:0007264//GO:0015991//GO:0006576 proton transport//G-protein coupled receptor signaling pathway//intracellular protein transport//vesicle-mediated transport//signal transduction//small GTPase mediated signal transduction//ATP hydrolysis coupled proton transport//cellular biogenic amine metabolic process GO:0019001//GO:0015078//GO:0003924//GO:0031683//GO:0005524//GO:0004871//GO:0005525 guanyl nucleotide binding//hydrogen ion transmembrane transporter activity//GTPase activity//G-protein beta/gamma-subunit complex binding//ATP binding//signal transducer activity//GTP binding GO:0005794//GO:0033179//GO:0005783 Golgi apparatus//proton-transporting V-type ATPase, V0 domain//endoplasmic reticulum KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.38204 BP_3 843.11 7.61 5632 332376995 AEE63637.1 1603 4.8e-175 unknown [Dendroctonus ponderosae]>gi|478252044|gb|ENN72475.1| hypothetical protein YQE_10817, partial [Dendroctonus ponderosae] 768439449 XM_011563053.1 264 4.48912e-133 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K04712 DEGS sphingolipid delta-4 desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K04712 Q3ZBY7 1091 4.7e-117 Sphingolipid delta(4)-desaturase DES1 OS=Bos taurus GN=DEGS1 PE=2 SV=1 PF00769//PF01233//PF00487 Ezrin/radixin/moesin family//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//Fatty acid desaturase GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0008092//GO:0004379 cytoskeletal protein binding//glycylpeptide N-tetradecanoyltransferase activity GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG2987 Fatty acid desaturase Cluster-8309.38206 BP_3 236.33 6.93 1935 642917912 XP_008191379.1 1024 2.3e-108 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9GLD9 552 5.1e-55 UDP-glucuronosyltransferase 2B33 OS=Macaca mulatta GN=UGT2B33 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.38207 BP_3 16.49 0.35 2588 646700583 KDR10693.1 2381 1.4e-265 Propionyl-CoA carboxylase alpha chain, mitochondrial [Zootermopsis nevadensis] 852460626 CP011799.1 37 3.16282e-07 Streptomyces sp. PBH53 genome K01965 PCCA, pccA propionyl-CoA carboxylase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01965 P05165 2116 3.0e-236 Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens GN=PCCA PE=1 SV=4 PF02655//PF07478//PF02786 ATP-grasp domain//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain GO:0009252//GO:0046436 peptidoglycan biosynthetic process//D-alanine metabolic process GO:0046872//GO:0008716//GO:0005524 metal ion binding//D-alanine-D-alanine ligase activity//ATP binding -- -- KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit Cluster-8309.38210 BP_3 337.00 15.66 1329 91093459 XP_967209.1 1340 3.6e-145 PREDICTED: uncharacterized protein LOC655563 [Tribolium castaneum] 642930682 XM_962116.2 135 5.33407e-62 PREDICTED: Tribolium castaneum uncharacterized LOC655563 (LOC655563), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38211 BP_3 70.47 2.25 1799 646700412 KDR10573.1 1580 7.2e-173 Adenylosuccinate synthetase [Zootermopsis nevadensis] -- -- -- -- -- K01939 purA, ADSS adenylosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01939 Q17G75 1538 2.2e-169 Adenylosuccinate synthetase OS=Aedes aegypti GN=AAEL003161 PE=3 SV=1 PF00709//PF01640 Adenylosuccinate synthetase//Peptidase C10 family GO:0006164//GO:0006531//GO:0006144//GO:0006522//GO:0006508 purine nucleotide biosynthetic process//aspartate metabolic process//purine nucleobase metabolic process//alanine metabolic process//proteolysis GO:0008234//GO:0005525//GO:0004019 cysteine-type peptidase activity//GTP binding//adenylosuccinate synthase activity -- -- KOG1355 Adenylosuccinate synthase Cluster-8309.38212 BP_3 457.15 7.14 3376 91090103 XP_970810.1 1845 2.5e-203 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 160947857 EU258622.1 288 1.2204e-146 Spodoptera exigua ribosomal protein L10 (RpL10) mRNA, complete cds K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O96647 1088 6.2e-117 60S ribosomal protein L10 OS=Bombyx mandarina GN=RpL10 PE=2 SV=1 PF13639//PF00252//PF14634//PF03854 Ring finger domain//Ribosomal protein L16p/L10e//zinc-RING finger domain//P-11 zinc finger GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003723//GO:0003735//GO:0008270//GO:0005515 RNA binding//structural constituent of ribosome//zinc ion binding//protein binding GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.38213 BP_3 94.41 4.37 1333 189236439 XP_001814289.1 1020 4.6e-108 PREDICTED: uncharacterized protein LOC100142575 [Tribolium castaneum]>gi|270005928|gb|EFA02376.1| hypothetical protein TcasGA2_TC008051 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38215 BP_3 42.93 2.02 1318 642936134 XP_008198313.1 1531 2.5e-167 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 337 2.70502e-174 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q55EH8 566 8.2e-57 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF13304//PF01637//PF03193//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter -- -- GO:0003924//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ATP binding//GTP binding//ATPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.38216 BP_3 2265.41 35.36 3380 270012664 EFA09112.1 2981 0.0e+00 hypothetical protein TcasGA2_TC015972 [Tribolium castaneum] 462330734 APGK01039925.1 69 6.73678e-25 Dendroctonus ponderosae Seq01039935, whole genome shotgun sequence -- -- -- -- Q8TBP0 1284 1.2e-139 TBC1 domain family member 16 OS=Homo sapiens GN=TBC1D16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.38218 BP_3 32.82 0.63 2805 270014457 EFA10905.1 2538 9.2e-284 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 866 2.9e-91 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF01289//PF00665 Thiol-activated cytolysin//Integrase core domain GO:0009405//GO:0015074 pathogenesis//DNA integration GO:0015485 cholesterol binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.38220 BP_3 119.00 9.62 888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38221 BP_3 144.79 1.23 5980 91078256 XP_970842.1 3273 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 558207907 XM_006132981.1 93 5.45429e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2064 7.4e-230 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF05773//PF03810//PF08506//PF05743 RWD domain//Importin-beta N-terminal domain//Cse1//UEV domain GO:0006464//GO:0015031//GO:0006886 cellular protein modification process//protein transport//intracellular protein transport GO:0008565//GO:0008536//GO:0005515 protein transporter activity//Ran GTPase binding//protein binding GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.38222 BP_3 24.10 0.54 2451 642923758 XP_008193872.1 822 7.7e-85 PREDICTED: activating signal cointegrator 1 complex subunit 1-like [Tribolium castaneum]>gi|270006936|gb|EFA03384.1| hypothetical protein TcasGA2_TC013370 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D8Z1 280 2.2e-23 Activating signal cointegrator 1 complex subunit 1 OS=Mus musculus GN=Ascc1 PE=2 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG2814 Transcription coactivator complex, P50 component (LigT RNA ligase/phosphodiesterase family) Cluster-8309.38224 BP_3 989.60 3.62 13456 189234010 XP_972656.2 5079 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X4 [Tribolium castaneum]>gi|270014736|gb|EFA11184.1| hypothetical protein TcasGA2_TC004792 [Tribolium castaneum] 642911788 XM_967563.3 622 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 Q811L6 2418 1.5e-270 Microtubule-associated serine/threonine-protein kinase 4 OS=Mus musculus GN=Mast4 PE=2 SV=3 PF08926//PF06293//PF00069//PF00595//PF00412//PF07714//PF13180 Domain of unknown function (DUF1908)//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//PDZ domain (Also known as DHR or GLGF)//LIM domain//Protein tyrosine kinase//PDZ domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0008270//GO:0004672//GO:0004674//GO:0000287//GO:0005524//GO:0005515 phosphotransferase activity, alcohol group as acceptor//zinc ion binding//protein kinase activity//protein serine/threonine kinase activity//magnesium ion binding//ATP binding//protein binding GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.38225 BP_3 17.58 0.45 2182 478256283 ENN76473.1 1934 7.8e-214 hypothetical protein YQE_06927, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TBP0 587 5.0e-59 TBC1 domain family member 16 OS=Homo sapiens GN=TBC1D16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.38227 BP_3 22.58 1.48 1025 195470156 XP_002087374.1 227 3.2e-16 GE16582 [Drosophila yakuba]>gi|194173475|gb|EDW87086.1| GE16582 [Drosophila yakuba] -- -- -- -- -- K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 Q4R924 182 2.2e-12 S-adenosylmethionine synthase isoform type-2 OS=Macaca fascicularis GN=MAT2A PE=2 SV=1 PF00438 S-adenosylmethionine synthetase, N-terminal domain GO:0006555//GO:0006556//GO:0015948//GO:0006730 methionine metabolic process//S-adenosylmethionine biosynthetic process//methanogenesis//one-carbon metabolic process GO:0046872//GO:0004478//GO:0005524 metal ion binding//methionine adenosyltransferase activity//ATP binding -- -- KOG1506 S-adenosylmethionine synthetase Cluster-8309.38229 BP_3 453.48 14.50 1799 332376787 AEE63533.1 272 3.4e-21 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 780659103 XM_011694063.1 55 2.15466e-17 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 244 2.4e-19 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF02776//PF00270 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//DEAD/DEAH box helicase -- -- GO:0030976//GO:0005524//GO:0003676 thiamine pyrophosphate binding//ATP binding//nucleic acid binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.38230 BP_3 14319.01 84.61 8449 91085895 XP_968071.1 2691 5.0e-301 PREDICTED: nucleolar protein 6 [Tribolium castaneum]>gi|270009966|gb|EFA06414.1| hypothetical protein TcasGA2_TC009293 [Tribolium castaneum] 158524687 EU074287.1 98 1.28215e-40 Alcyonidium diaphanum methionine adenosyltransferase mRNA, partial cds K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 P40320 1680 3.5e-185 S-adenosylmethionine synthase OS=Drosophila melanogaster GN=Sam-S PE=2 SV=2 PF00961//PF02772//PF05864//PF00438//PF02773//PF00580 LAGLIDADG endonuclease//S-adenosylmethionine synthetase, central domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//S-adenosylmethionine synthetase, N-terminal domain//S-adenosylmethionine synthetase, C-terminal domain//UvrD/REP helicase N-terminal domain GO:0006556//GO:0006206//GO:0006555//GO:0006351//GO:0006144 S-adenosylmethionine biosynthetic process//pyrimidine nucleobase metabolic process//methionine metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0004478//GO:0003677//GO:0004519//GO:0003899//GO:0005524 methionine adenosyltransferase activity//DNA binding//endonuclease activity//DNA-directed RNA polymerase activity//ATP binding GO:0005730 nucleolus KOG1506 S-adenosylmethionine synthetase Cluster-8309.38231 BP_3 83.00 5.90 970 546685525 ERL95012.1 792 9.1e-82 hypothetical protein D910_12282 [Dendroctonus ponderosae] 704288483 XM_010159848.1 45 4.14249e-12 PREDICTED: Eurypyga helias phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like (LOC104515752), partial mRNA K00871 PHKG phosphorylase kinase gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00871 Q9DB30 533 4.0e-53 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Mus musculus GN=Phkg2 PE=2 SV=2 PF05194//PF01764//PF07714//PF06293//PF00069 UreE urease accessory protein, C-terminal domain//Lipase (class 3)//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0019627//GO:0006629//GO:0006461 protein phosphorylation//urea metabolic process//lipid metabolic process//protein complex assembly GO:0016151//GO:0005524//GO:0004672//GO:0016773 nickel cation binding//ATP binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.38232 BP_3 2055.00 30.22 3569 642929032 XP_008195661.1 2709 1.7e-303 PREDICTED: 5'-3' exoribonuclease 2 homolog [Tribolium castaneum] 759098400 XM_011370835.1 74 1.18262e-27 PREDICTED: Pteropus vampyrus 5'-3' exoribonuclease 2 (XRN2), mRNA K12619 XRN2, RAT1 5'-3' exoribonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12619 Q9VM71 2052 1.1e-228 5'-3' exoribonuclease 2 homolog OS=Drosophila melanogaster GN=Rat1 PE=1 SV=2 PF00098//PF03159 Zinc knuckle//XRN 5'-3' exonuclease N-terminus -- -- GO:0004527//GO:0003676//GO:0008270 exonuclease activity//nucleic acid binding//zinc ion binding -- -- KOG2044 5'-3' exonuclease HKE1/RAT1 Cluster-8309.38233 BP_3 33.92 0.85 2205 478262423 ENN81094.1 2576 2.8e-288 hypothetical protein YQE_02462, partial [Dendroctonus ponderosae]>gi|546673644|gb|ERL85208.1| hypothetical protein D910_02629 [Dendroctonus ponderosae] 591382847 XM_007065827.1 100 2.55845e-42 PREDICTED: Chelonia mydas cullin-associated and neddylation-dissociated 1 (CAND1), transcript variant X1, mRNA K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 1804 3.8e-200 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1824 TATA-binding protein-interacting protein Cluster-8309.38235 BP_3 952.83 12.91 3850 478254875 ENN75111.1 1428 6.5e-155 hypothetical protein YQE_08424, partial [Dendroctonus ponderosae] 642926583 XM_962896.2 307 3.82028e-157 PREDICTED: Tribolium castaneum lipoma-preferred partner homolog (LOC656358), transcript variant X2, mRNA K16676 LPP lipoma-prefererred partner http://www.genome.jp/dbget-bin/www_bget?ko:K16676 Q5F464 812 7.2e-85 Lipoma-preferred partner homolog OS=Gallus gallus GN=LPP PE=2 SV=1 PF06467//PF00412 MYM-type Zinc finger with FCS sequence motif//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.38237 BP_3 358.76 42.04 703 270003282 EEZ99729.1 276 4.5e-22 hypothetical protein TcasGA2_TC002496 [Tribolium castaneum] 347810671 JN410829.1 87 1.32966e-35 Plutella xylostella tyrosine hydroxylase mRNA, complete cds K00501 TH tyrosine 3-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00501 P18459 261 1.0e-21 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38238 BP_3 1429.14 4.86 14472 642924616 XP_008194365.1 1950 7.2e-215 PREDICTED: uncharacterized protein LOC663601 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 2.0e-71 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF00891//PF12529//PF05933//PF01833//PF00554 O-methyltransferase//Xylosyltransferase C terminal//Fungal ATP synthase protein 8 (A6L)//IPT/TIG domain//Rel homology DNA-binding domain GO:0006024//GO:0015986//GO:0006355//GO:0030206//GO:0015992 glycosaminoglycan biosynthetic process//ATP synthesis coupled proton transport//regulation of transcription, DNA-templated//chondroitin sulfate biosynthetic process//proton transport GO:0008171//GO:0003677//GO:0005515//GO:0015078//GO:0030158//GO:0003700 O-methyltransferase activity//DNA binding//protein binding//hydrogen ion transmembrane transporter activity//protein xylosyltransferase activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0000276 transcription factor complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.38239 BP_3 1173.26 23.89 2659 91084515 XP_967225.1 751 1.4e-76 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891//GO:0003723 endoribonuclease activity, producing 5'-phosphomonoesters//RNA binding -- -- -- -- Cluster-8309.38240 BP_3 5.00 0.69 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38241 BP_3 1854.00 47.83 2160 478252042 ENN72473.1 843 2.5e-87 hypothetical protein YQE_10815, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38244 BP_3 638.28 16.72 2132 546679409 ERL89880.1 1808 3.1e-199 hypothetical protein D910_07239 [Dendroctonus ponderosae] -- -- -- -- -- K01587 PAICS phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01587 Q9I7S8 1473 8.9e-162 Multifunctional protein ADE2 OS=Drosophila melanogaster GN=ade5 PE=2 SV=2 PF00763//PF00731 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//AIR carboxylase GO:0055114//GO:0046487//GO:0009396//GO:0006189 oxidation-reduction process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//'de novo' IMP biosynthetic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase Cluster-8309.38245 BP_3 2292.26 28.26 4201 91092490 XP_968084.1 986 1.3e-103 PREDICTED: protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [Tribolium castaneum]>gi|270012934|gb|EFA09382.1| hypothetical protein TcasGA2_TC001944 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7K4 828 1.1e-86 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Pongo abelii GN=PCMTD2 PE=2 SV=1 PF08123//PF01135//PF08704//PF07525 Histone methylation protein DOT1//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//tRNA methyltransferase complex GCD14 subunit//SOCS box GO:0006464//GO:0030488//GO:0009451//GO:0006479//GO:0035556//GO:0006554//GO:0046500//GO:0008033 cellular protein modification process//tRNA methylation//RNA modification//protein methylation//intracellular signal transduction//lysine catabolic process//S-adenosylmethionine metabolic process//tRNA processing GO:0018024//GO:0016429//GO:0004719 histone-lysine N-methyltransferase activity//tRNA (adenine-N1-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0031515 tRNA (m1A) methyltransferase complex KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.38246 BP_3 102.47 1.86 2940 642913109 XP_008201396.1 1484 1.6e-161 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 186 5.33631e-90 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 926 3.3e-98 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.38247 BP_3 5283.31 95.40 2961 642918282 XP_008191443.1 3855 0.0e+00 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X2 [Tribolium castaneum] 195430887 XM_002063444.1 411 0 Drosophila willistoni GK21381 (Dwil\GK21381), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 3178 0.0e+00 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 PF13181//PF05009//PF13174//PF13371//PF13374//PF00515//PF02259//PF13176//PF13414 Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat//TPR repeat GO:0016032 viral process GO:0005515 protein binding GO:0042025 host cell nucleus KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.38248 BP_3 215.80 4.87 2426 91093505 XP_969151.1 2464 3.0e-275 PREDICTED: NADP-dependent malic enzyme [Tribolium castaneum]>gi|270002678|gb|EEZ99125.1| hypothetical protein TcasGA2_TC005232 [Tribolium castaneum] 194765020 XM_001964590.1 273 1.90514e-138 Drosophila ananassae GF23280 (Dana\GF23280), mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1653 1.4e-182 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF01420//PF03949//PF00390 Type I restriction modification DNA specificity domain//Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0006304//GO:0006108//GO:0055114//GO:0006090//GO:0006099//GO:0015976 DNA modification//malate metabolic process//oxidation-reduction process//pyruvate metabolic process//tricarboxylic acid cycle//carbon utilization GO:0051287//GO:0003677//GO:0046872//GO:0004471 NAD binding//DNA binding//metal ion binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.38249 BP_3 79.00 7.45 803 642923944 XP_008193936.1 224 5.5e-16 PREDICTED: flexible cuticle protein 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45589 157 1.3e-09 Flexible cuticle protein 12 OS=Hyalophora cecropia GN=CP12 PE=2 SV=1 PF10584//PF00379 Proteasome subunit A N-terminal signature//Insect cuticle protein GO:0006511 ubiquitin-dependent protein catabolic process GO:0004175//GO:0042302 endopeptidase activity//structural constituent of cuticle GO:0019773 proteasome core complex, alpha-subunit complex -- -- Cluster-8309.38251 BP_3 456.78 4.86 4819 642914654 XP_008190301.1 1656 3.0e-181 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.84246e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.3e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.38252 BP_3 29.08 0.66 2403 642923425 XP_008193739.1 408 7.6e-37 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 199 5.4e-14 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38253 BP_3 475.18 19.91 1442 642923427 XP_008193740.1 1286 7.1e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 385 8.8e-36 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.38254 BP_3 1969.05 28.32 3643 91084273 XP_971218.1 3014 0.0e+00 PREDICTED: ATP-binding cassette sub-family D member 2 [Tribolium castaneum]>gi|270008750|gb|EFA05198.1| hypothetical protein TcasGA2_TC015333 [Tribolium castaneum] -- -- -- -- -- K05676 ABCD2, ALDL1 ATP-binding cassette, subfamily D (ALD), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05676 Q9UBJ2 1711 3.9e-189 ATP-binding cassette sub-family D member 2 OS=Homo sapiens GN=ABCD2 PE=1 SV=1 PF06472//PF00488//PF00005//PF07728//PF13304 ABC transporter transmembrane region 2//MutS domain V//ABC transporter//AAA domain (dynein-related subfamily)//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006200//GO:0006810//GO:0006298//GO:0055085 obsolete ATP catabolic process//transport//mismatch repair//transmembrane transport GO:0005524//GO:0042626//GO:0016887//GO:0030983 ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//mismatched DNA binding GO:0016021 integral component of membrane KOG0064 Peroxisomal long-chain acyl-CoA transporter, ABC superfamily Cluster-8309.38256 BP_3 31.65 0.50 3340 478255027 ENN75259.1 3164 0.0e+00 hypothetical protein YQE_08175, partial [Dendroctonus ponderosae]>gi|546673315|gb|ERL84943.1| hypothetical protein D910_02366 [Dendroctonus ponderosae] 749751938 XM_011139992.1 405 0 PREDICTED: Harpegnathos saltator regulator of nonsense transcripts 1 (LOC105182511), transcript variant X4, mRNA K14326 UPF1, RENT1 regulator of nonsense transcripts 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14326 Q9EPU0 2374 4.7e-266 Regulator of nonsense transcripts 1 OS=Mus musculus GN=Upf1 PE=1 SV=2 PF07728//PF01443//PF00004//PF00437//PF00448//PF00580//PF04851//PF00270//PF05970 AAA domain (dynein-related subfamily)//Viral (Superfamily 1) RNA helicase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//UvrD/REP helicase N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//PIF1-like helicase GO:0000723//GO:0006614//GO:0006810//GO:0006281 telomere maintenance//SRP-dependent cotranslational protein targeting to membrane//transport//DNA repair GO:0005525//GO:0003676//GO:0016887//GO:0003678//GO:0005524//GO:0016787//GO:0003677 GTP binding//nucleic acid binding//ATPase activity//DNA helicase activity//ATP binding//hydrolase activity//DNA binding GO:0005657 replication fork KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.38258 BP_3 1484.47 48.83 1757 189234454 XP_967960.2 2117 3.8e-235 PREDICTED: aldehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270002022|gb|EEZ98469.1| hypothetical protein TcasGA2_TC000960 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11884 1726 3.4e-191 Aldehyde dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Aldh2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491//GO:0016620 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.38259 BP_3 362.12 3.15 5828 642917757 XP_008191356.1 425 2.0e-38 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 54 2.54372e-16 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.38260 BP_3 1130.98 14.15 4144 642917757 XP_008191356.1 961 9.9e-101 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917758 XM_008193135.1 165 3.56214e-78 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01695//PF03285 IstB-like ATP binding protein//Paralemmin GO:0008360 regulation of cell shape GO:0005524 ATP binding GO:0016020 membrane -- -- Cluster-8309.38261 BP_3 9.65 0.35 1637 478256432 ENN76619.1 1029 5.1e-109 hypothetical protein YQE_06876, partial [Dendroctonus ponderosae] 766918334 XM_011499440.1 192 1.36038e-93 PREDICTED: Ceratosolen solmsi marchali protein enhancer of sevenless 2B (LOC105362095), mRNA K04364 GRB2 growth factor receptor-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04364 Q08012 948 5.2e-101 Protein enhancer of sevenless 2B OS=Drosophila melanogaster GN=drk PE=1 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains Cluster-8309.38262 BP_3 57.33 4.39 921 642921730 XP_008199303.1 710 2.8e-72 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 540 6.0e-54 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.38263 BP_3 890.11 11.15 4139 642924128 XP_008194017.1 5637 0.0e+00 PREDICTED: neural-cadherin isoform X2 [Tribolium castaneum] 642924137 XM_008195801.1 1157 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X7, mRNA -- -- -- -- O15943 4738 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF03222//PF00868//PF00028 Tryptophan/tyrosine permease family//Transglutaminase family//Cadherin domain GO:0003333//GO:0007156//GO:0018149 amino acid transmembrane transport//homophilic cell adhesion via plasma membrane adhesion molecules//peptide cross-linking GO:0005509 calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.38265 BP_3 24.58 0.34 3806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38266 BP_3 77.55 0.46 8382 642934565 XP_008197717.1 3862 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF07714//PF06293//PF00069//PF01533 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Tospovirus nucleocapsid protein GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0016772//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring phosphorus-containing groups//ATP binding GO:0019013//GO:0016020 viral nucleocapsid//membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.38267 BP_3 1389.27 57.61 1454 478264196 ENN82174.1 547 3.5e-53 hypothetical protein YQE_01450, partial [Dendroctonus ponderosae] 676480291 XM_009063766.1 40 3.77847e-09 Lottia gigantea hypothetical protein mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q9CQC9 437 8.2e-42 GTP-binding protein SAR1b OS=Mus musculus GN=Sar1b PE=1 SV=1 PF00071//PF04670//PF00025//PF00503//PF06858 Ras family//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//G-protein alpha subunit//Nucleolar GTP-binding protein 1 (NOG1) GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0031683//GO:0003924//GO:0005525//GO:0019001//GO:0004871 G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.38270 BP_3 59.08 3.63 1076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38271 BP_3 170.78 2.82 3211 642918017 XP_008198981.1 460 9.5e-43 PREDICTED: protein LSM14 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K18749 LSM14, RAP55, SCD6 protein LSM14 http://www.genome.jp/dbget-bin/www_bget?ko:K18749 Q566L7 195 2.1e-13 Protein LSM14 homolog B OS=Xenopus tropicalis GN=lsm14b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1073 Uncharacterized mRNA-associated protein RAP55 Cluster-8309.38274 BP_3 364.17 2.73 6730 91082383 XP_968748.1 3389 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.06437e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2467 1.5e-276 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF02367//PF06414//PF01637//PF03266//PF03193//PF00005//PF00931//PF01580//PF01926//PF00158//PF13304//PF00664//PF02224//PF00437 Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Archaeal ATPase//NTPase//Protein of unknown function, DUF258//ABC transporter//NB-ARC domain//FtsK/SpoIIIE family//50S ribosome-binding GTPase//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Cytidylate kinase//Type II/IV secretion system protein GO:0006355//GO:0006810//GO:0006139//GO:0055085//GO:0006206//GO:0002949 regulation of transcription, DNA-templated//transport//nucleobase-containing compound metabolic process//transmembrane transport//pyrimidine nucleobase metabolic process//tRNA threonylcarbamoyladenosine modification GO:0042626//GO:0016301//GO:0016887//GO:0004127//GO:0000166//GO:0003924//GO:0008134//GO:0098519//GO:0005524//GO:0017111//GO:0005525//GO:0043531//GO:0003677 ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//cytidylate kinase activity//nucleotide binding//GTPase activity//transcription factor binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//nucleoside-triphosphatase activity//GTP binding//ADP binding//DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.38277 BP_3 10112.69 441.00 1397 478263077 ENN81477.1 931 1.0e-97 hypothetical protein YQE_02169, partial [Dendroctonus ponderosae]>gi|546682119|gb|ERL92100.1| hypothetical protein D910_09421 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38278 BP_3 3145.83 35.34 4582 478252433 ENN72856.1 1840 1.3e-202 hypothetical protein YQE_10505, partial [Dendroctonus ponderosae]>gi|478264876|gb|ENN82355.1| hypothetical protein YQE_01270, partial [Dendroctonus ponderosae] 157136696 XM_001656830.1 41 3.36457e-09 Aedes aegypti AAEL013617-RA partial mRNA -- -- -- -- P52757 903 2.4e-95 Beta-chimaerin OS=Homo sapiens GN=CHN2 PE=1 SV=2 PF01363//PF00620//PF04434//PF00130 FYVE zinc finger//RhoGAP domain//SWIM zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.38280 BP_3 140.88 1.67 4356 332373366 AEE61824.1 1272 9.0e-137 unknown [Dendroctonus ponderosae]>gi|478258142|gb|ENN78280.1| hypothetical protein YQE_05431, partial [Dendroctonus ponderosae] 391342831 XM_003745671.1 69 8.70302e-25 PREDICTED: Metaseiulus occidentalis GMP reductase 2-like (LOC100902322), mRNA K00364 E1.7.1.7, guaC GMP reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00364 Q9DCZ1 1150 5.2e-124 GMP reductase 1 OS=Mus musculus GN=Gmpr PE=2 SV=1 PF01070//PF01081//PF00478 FMN-dependent dehydrogenase//KDPG and KHG aldolase//IMP dehydrogenase / GMP reductase domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0016829//GO:0003824 oxidoreductase activity//lyase activity//catalytic activity -- -- KOG2550 IMP dehydrogenase/GMP reductase Cluster-8309.38281 BP_3 117.81 1.06 5625 91082383 XP_968748.1 3454 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2490 2.8e-279 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF16839//PF01926//PF13304//PF02714//PF00004//PF01637//PF02367//PF06414//PF00005//PF03193//PF00931 ABC transporter transmembrane region//Nematode antimicrobial peptide//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Calcium-dependent channel, 7TM region, putative phosphate//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ABC transporter//Protein of unknown function, DUF258//NB-ARC domain GO:0055085//GO:0006810//GO:0002949//GO:0098542 transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification//defense response to other organism GO:0005524//GO:0003924//GO:0043531//GO:0016301//GO:0016887//GO:0005525//GO:0017111//GO:0042626 ATP binding//GTPase activity//ADP binding//kinase activity//ATPase activity//GTP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0016020 integral component of membrane//membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.38282 BP_3 420.19 5.41 4033 546676948 ERL87872.1 1851 6.1e-204 hypothetical protein D910_05260 [Dendroctonus ponderosae] -- -- -- -- -- K10416 DYNC1LI, DNCLI dynein light intermediate chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10416 O43237 1017 1.3e-108 Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens GN=DYNC1LI2 PE=1 SV=1 PF08477//PF03193//PF00005//PF02892//PF00503//PF10662//PF13465 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ABC transporter//BED zinc finger//G-protein alpha subunit//Ethanolamine utilisation - propanediol utilisation//Zinc-finger double domain GO:0007264//GO:0007186//GO:0007165//GO:0006576 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction//cellular biogenic amine metabolic process GO:0046872//GO:0004871//GO:0016887//GO:0019001//GO:0005525//GO:0003924//GO:0003677//GO:0031683//GO:0005524 metal ion binding//signal transducer activity//ATPase activity//guanyl nucleotide binding//GTP binding//GTPase activity//DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding -- -- KOG2482 Predicted C2H2-type Zn-finger protein Cluster-8309.38283 BP_3 471.43 2.09 11178 642910658 XP_008200046.1 10447 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.38285 BP_3 212.08 7.27 1698 642910769 XP_008193402.1 1628 1.8e-178 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07926//PF10473 TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006606 protein import into nucleus GO:0042803//GO:0045502//GO:0008134 protein homodimerization activity//dynein binding//transcription factor binding GO:0030286//GO:0005667 dynein complex//transcription factor complex -- -- Cluster-8309.38286 BP_3 163.58 4.19 2173 91089699 XP_974834.1 1212 4.1e-130 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum]>gi|270011321|gb|EFA07769.1| hypothetical protein TcasGA2_TC005323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 173 5.1e-11 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF00856//PF13414//PF08411 SET domain//TPR repeat//Exonuclease C-terminal GO:0006281//GO:0006308 DNA repair//DNA catabolic process GO:0008852//GO:0005515 exodeoxyribonuclease I activity//protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.38288 BP_3 196.00 18.62 799 642930971 XP_008196161.1 624 2.3e-62 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103313779 [Tribolium castaneum] -- -- -- -- -- K04650 NCOR1, N-CoR nuclear receptor co-repressor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38289 BP_3 109.74 0.61 8899 91076206 XP_972459.1 2316 1.6e-257 PREDICTED: KN motif and ankyrin repeat domain-containing protein 2 [Tribolium castaneum]>gi|270014552|gb|EFA11000.1| hypothetical protein TcasGA2_TC004585 [Tribolium castaneum] 759076887 XM_011349892.1 70 4.96232e-25 PREDICTED: Cerapachys biroi KN motif and ankyrin repeat domain-containing protein 2-like (LOC105285603), transcript variant X3, mRNA -- -- -- -- Q14678 663 3.1e-67 KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens GN=KANK1 PE=1 SV=3 PF00130//PF07649//PF00628//PF13606//PF15182//PF01096//PF01300//PF02150//PF15898//PF13939//PF00023 Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain//PHD-finger//Ankyrin repeat//Otospiralin//Transcription factor S-II (TFIIS)//Telomere recombination//RNA polymerases M/15 Kd subunit//cGMP-dependent protein kinase interacting domain//Toxin TisB, type I toxin-antitoxin system//Ankyrin repeat GO:0006820//GO:0009432//GO:0006206//GO:0006144//GO:0006351//GO:0035556//GO:0055114//GO:0022611//GO:0007605 anion transport//SOS response//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//intracellular signal transduction//oxidation-reduction process//dormancy process//sensory perception of sound GO:0003676//GO:0005515//GO:0003677//GO:0047134//GO:0003725//GO:0008270//GO:0019901//GO:0005253//GO:0003899 nucleic acid binding//protein binding//DNA binding//protein-disulfide reductase activity//double-stranded RNA binding//zinc ion binding//protein kinase binding//anion channel activity//DNA-directed RNA polymerase activity GO:0005730//GO:0005887 nucleolus//integral component of plasma membrane KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.38290 BP_3 463.35 2.62 8814 642918564 XP_008199298.1 1069 6.3e-113 PREDICTED: large proline-rich protein BAG6 isoform X2 [Tribolium castaneum] 242016373 XM_002428751.1 60 1.7802e-19 Pediculus humanus corporis RWD domain-containing protein, putative, mRNA -- -- -- -- A4IH17 240 3.5e-18 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF14560//PF00240//PF05773//PF07469 Ubiquitin-like domain//Ubiquitin family//RWD domain//Domain of unknown function (DUF1518) -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4018 Uncharacterized conserved protein, contains RWD domain Cluster-8309.38291 BP_3 13.00 0.52 1506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38292 BP_3 607.69 15.72 2155 91089283 XP_970929.1 1290 3.6e-139 PREDICTED: protein phosphatase PTC7 homolog [Tribolium castaneum]>gi|270012497|gb|EFA08945.1| hypothetical protein TcasGA2_TC006652 [Tribolium castaneum] 768444891 XM_011566017.1 107 3.21051e-46 PREDICTED: Plutella xylostella protein phosphatase PTC7 homolog (LOC105394173), mRNA -- -- -- -- Q6GR25 678 1.4e-69 Protein phosphatase PTC7 homolog OS=Xenopus laevis GN=pptc7 PE=2 SV=1 PF07228//PF00481 Stage II sporulation protein E (SpoIIE)//Protein phosphatase 2C GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1379 Serine/threonine protein phosphatase Cluster-8309.38293 BP_3 477.55 18.45 1539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.38295 BP_3 130.38 1.70 3982 642924094 XP_008194003.1 2342 7.0e-261 PREDICTED: lysine--tRNA ligase isoform X1 [Tribolium castaneum] 157106532 XM_001649316.1 207 1.53662e-101 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1951 6.2e-217 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF01336//PF01409//PF17121//PF00152 OB-fold nucleic acid binding domain//tRNA synthetases class II core domain (F)//Zinc finger, C3HC4 type (RING finger)//tRNA synthetases class II (D, K and N) GO:0043039//GO:0006418 tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0000049//GO:0005515//GO:0005524//GO:0004812//GO:0003676//GO:0008270//GO:0000166 tRNA binding//protein binding//ATP binding//aminoacyl-tRNA ligase activity//nucleic acid binding//zinc ion binding//nucleotide binding GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.38296 BP_3 3704.67 74.67 2683 546673028 ERL84714.1 2012 8.6e-223 hypothetical protein D910_02139 [Dendroctonus ponderosae] 826423471 XM_012671271.1 43 1.51447e-10 PREDICTED: Monomorium pharaonis putative inorganic phosphate cotransporter (LOC105831269), mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 946 1.4e-100 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38297 BP_3 15.20 0.49 1802 478257160 ENN77323.1 1843 2.3e-203 hypothetical protein YQE_06149, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IVI9 340 1.8e-30 Nostrin OS=Homo sapiens GN=NOSTRIN PE=1 SV=2 PF00628//PF02185//PF05191//PF00130 PHD-finger//Hr1 repeat//Adenylate kinase, active site lid//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007165//GO:0046034//GO:0006144//GO:0035556 signal transduction//ATP metabolic process//purine nucleobase metabolic process//intracellular signal transduction GO:0005515//GO:0004017 protein binding//adenylate kinase activity -- -- KOG4429 Uncharacterized conserved protein, contains SH3 and FCH domains Cluster-8309.38298 BP_3 190.13 1.04 9077 642923742 XP_966686.2 1948 7.7e-215 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X9 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O35547 1209 1.6e-130 Long-chain-fatty-acid--CoA ligase 4 OS=Rattus norvegicus GN=Acsl4 PE=1 SV=1 PF15138//PF00908//PF06624//PF09259//PF00501 Syncollin//dTDP-4-dehydrorhamnose 3,5-epimerase//Ribosome associated membrane protein RAMP4//Fungal immunomodulatory protein Fve//AMP-binding enzyme GO:0006887//GO:0002682//GO:0030639//GO:0019872//GO:0008152//GO:0009117 exocytosis//regulation of immune system process//polyketide biosynthetic process//streptomycin biosynthetic process//metabolic process//nucleotide metabolic process GO:0030246//GO:0008830//GO:0003824 carbohydrate binding//dTDP-4-dehydrorhamnose 3,5-epimerase activity//catalytic activity GO:0030667//GO:0005783 secretory granule membrane//endoplasmic reticulum KOG1180 Acyl-CoA synthetase Cluster-8309.38299 BP_3 965.24 25.41 2123 642911450 XP_973171.3 2475 1.4e-276 PREDICTED: cullin-associated NEDD8-dissociated protein 1 [Tribolium castaneum]>gi|270014883|gb|EFA11331.1| hypothetical protein TcasGA2_TC010870 [Tribolium castaneum] -- -- -- -- -- K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 2026 6.7e-226 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985//PF08064//PF00790//PF07062//PF01602//PF07571 HEAT repeat//UME (NUC010) domain//VHS domain//Clc-like//Adaptin N terminal region//TAF6 C-terminal HEAT repeat domain GO:0009069//GO:0051090//GO:0016310//GO:0006886//GO:0016192 serine family amino acid metabolic process//regulation of sequence-specific DNA binding transcription factor activity//phosphorylation//intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0004674 protein binding//protein serine/threonine kinase activity GO:0005634//GO:0016021//GO:0030117 nucleus//integral component of membrane//membrane coat KOG1824 TATA-binding protein-interacting protein Cluster-8309.38301 BP_3 4106.50 77.61 2842 642925507 XP_008194579.1 1970 6.8e-218 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.42634e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 P47820 1312 5.6e-143 Angiotensin-converting enzyme OS=Rattus norvegicus GN=Ace PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.38302 BP_3 7435.69 143.51 2789 642925507 XP_008194579.1 1970 6.7e-218 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.36163e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 1312 5.5e-143 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.38303 BP_3 378.06 7.91 2596 91088273 XP_967838.1 482 2.2e-45 PREDICTED: protein scylla [Tribolium castaneum]>gi|270012158|gb|EFA08606.1| hypothetical protein TcasGA2_TC006266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTH4 254 2.4e-20 Protein scylla OS=Drosophila melanogaster GN=scyl PE=2 SV=1 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.38304 BP_3 223.00 6.51 1942 546681034 ERL91199.1 388 1.3e-34 hypothetical protein D910_08538 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38305 BP_3 446.06 5.61 4122 390198528 AFL70631.1 1230 6.3e-132 putative hypoxia-inducible factor 1 alpha [Callosobruchus maculatus] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38306 BP_3 375.17 2.22 8431 612027814 XP_007492786.1 362 5.8e-31 PREDICTED: zinc finger protein 208-like, partial [Monodelphis domestica] -- -- -- -- -- -- -- -- -- Q96NI8 342 5.0e-30 Zinc finger protein 570 OS=Homo sapiens GN=ZNF570 PE=2 SV=1 PF00508//PF00096//PF13465//PF09606//PF08452//PF02724//PF13912 E2 (early) protein, N terminal//Zinc finger, C2H2 type//Zinc-finger double domain//ARC105 or Med15 subunit of Mediator complex non-fungal//DNA polymerase family B exonuclease domain, N-terminal//CDC45-like protein//C2H2-type zinc finger GO:0006355//GO:0006357//GO:0006260//GO:0006275//GO:0016032//GO:0006270 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//DNA replication//regulation of DNA replication//viral process//DNA replication initiation GO:0046872//GO:0001104//GO:0003887 metal ion binding//RNA polymerase II transcription cofactor activity//DNA-directed DNA polymerase activity GO:0016592//GO:0042575 mediator complex//DNA polymerase complex -- -- Cluster-8309.38310 BP_3 158.00 2.60 3221 270015796 EFA12244.1 1314 9.0e-142 hypothetical protein TcasGA2_TC005276 [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 Q7T3E6 302 8.2e-26 Polycomb complex protein BMI-1-B OS=Danio rerio GN=bmi1b PE=2 SV=1 PF00097//PF17121//PF12678//PF12861//PF14634//PF13639//PF11789 Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Ring finger domain//Zinc-finger of the MIZ type in Nse subunit GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG2660 Locus-specific chromosome binding proteins Cluster-8309.38311 BP_3 77.80 1.79 2390 478251374 ENN71840.1 586 1.7e-57 hypothetical protein YQE_11459, partial [Dendroctonus ponderosae] 642926047 XM_964823.2 77 1.69488e-29 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 411 1.4e-38 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF04869//PF00171 Uso1 / p115 like vesicle tethering protein, head region//Aldehyde dehydrogenase family GO:0008152//GO:0055114//GO:0006886//GO:0048280 metabolic process//oxidation-reduction process//intracellular protein transport//vesicle fusion with Golgi apparatus GO:0016491 oxidoreductase activity GO:0000139//GO:0005737 Golgi membrane//cytoplasm KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.38312 BP_3 603.51 31.00 1230 674304042 AIL23552.1 751 6.6e-77 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q2NL00 415 2.5e-39 Glutathione S-transferase theta-1 OS=Bos taurus GN=GSTT1 PE=2 SV=3 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG0867 Glutathione S-transferase Cluster-8309.38313 BP_3 198.75 2.11 4827 270004647 EFA01095.1 988 8.5e-104 hypothetical protein TcasGA2_TC004018 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWG4 220 4.0e-16 Uncharacterized protein KIAA1755 homolog OS=Mus musculus PE=2 SV=2 PF01708//PF16099 Geminivirus putative movement protein//Recq-mediated genome instability protein 1, C-terminal OB-fold GO:0046740 transport of virus in host, cell to cell GO:0000166 nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.38314 BP_3 242.80 1.75 6996 91084043 XP_967085.1 1345 5.0e-145 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 157 1.68914e-73 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1123 1.1e-120 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF10415//PF00491//PF01607//PF01029//PF01336 Fumarase C C-terminus//Arginase family//Chitin binding Peritrophin-A domain//NusB family//OB-fold nucleic acid binding domain GO:0006030//GO:0019643//GO:0006355//GO:0006099//GO:0006106 chitin metabolic process//reductive tricarboxylic acid cycle//regulation of transcription, DNA-templated//tricarboxylic acid cycle//fumarate metabolic process GO:0003723//GO:0003676//GO:0016829//GO:0046872//GO:0004333//GO:0008061 RNA binding//nucleic acid binding//lyase activity//metal ion binding//fumarate hydratase activity//chitin binding GO:0005576//GO:0045239 extracellular region//tricarboxylic acid cycle enzyme complex KOG1317 Fumarase Cluster-8309.38315 BP_3 2021.03 38.24 2839 642932670 XP_008196939.1 401 5.9e-36 PREDICTED: BAG domain-containing protein Samui isoform X2 [Tribolium castaneum] -- -- -- -- -- K09558 BAG4 BCL2-associated athanogene 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09558 Q9BLJ6 306 2.5e-26 BAG domain-containing protein Samui OS=Bombyx mori GN=Samui PE=2 SV=1 PF02179 BAG domain -- -- GO:0051087 chaperone binding -- -- KOG4361 BCL2-associated athanogene-like proteins and related BAG family chaperone regulators Cluster-8309.38317 BP_3 1279.00 47.41 1592 91079450 XP_969249.1 1849 4.1e-204 PREDICTED: venom serine carboxypeptidase [Tribolium castaneum]>gi|270016070|gb|EFA12518.1| hypothetical protein TcasGA2_TC002692 [Tribolium castaneum] -- -- -- -- -- K09645 CPVL vitellogenic carboxypeptidase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K09645 C9WMM5 1403 8.7e-154 Venom serine carboxypeptidase OS=Apis mellifera PE=2 SV=1 PF00450//PF06971 Serine carboxypeptidase//Putative DNA-binding protein N-terminus GO:0006508//GO:0045892//GO:0051775 proteolysis//negative regulation of transcription, DNA-templated//response to redox state GO:0004185 serine-type carboxypeptidase activity GO:0005737 cytoplasm KOG1282 Serine carboxypeptidases (lysosomal cathepsin A) Cluster-8309.38318 BP_3 170.76 1.14 7515 642918059 XP_008193846.1 6483 0.0e+00 PREDICTED: nucleoprotein TPR isoform X1 [Tribolium castaneum] -- -- -- -- -- K09291 TPR, MLP1, MLP2 nucleoprotein TPR http://www.genome.jp/dbget-bin/www_bget?ko:K09291 A1Z8P9 2086 2.6e-232 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07544//PF05294//PF06005//PF02186//PF07926 RNA polymerase II transcription mediator complex subunit 9//Scorpion short toxin//Protein of unknown function (DUF904)//TFIIE beta subunit core domain//TPR/MLP1/MLP2-like protein GO:0006606//GO:0006357//GO:0006367//GO:0000917//GO:0043093//GO:0009405 protein import into nucleus//regulation of transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//barrier septum assembly//FtsZ-dependent cytokinesis//pathogenesis GO:0001104 RNA polymerase II transcription cofactor activity GO:0005576//GO:0005737//GO:0016592 extracellular region//cytoplasm//mediator complex KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.38319 BP_3 374.61 8.46 2427 642938988 XP_008200105.1 1045 1.1e-110 PREDICTED: serine protease inhibitor 3/4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 586 7.3e-59 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38320 BP_3 656.04 18.49 2002 642938992 XP_008200107.1 1023 3.1e-108 PREDICTED: serine protease inhibitor 3/4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 569 5.6e-57 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38322 BP_3 604.32 16.81 2024 642926804 XP_008195020.1 1258 1.8e-135 PREDICTED: vacuole membrane protein 1 isoform X2 [Tribolium castaneum] 241594857 XM_002404356.1 107 3.01213e-46 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q9XWU8 782 1.1e-81 Ectopic P granules protein 3 OS=Caenorhabditis elegans GN=epg-3 PE=2 SV=2 PF01741//PF00323 Large-conductance mechanosensitive channel, MscL//Mammalian defensin GO:0006952//GO:0006811//GO:0006810 defense response//ion transport//transport GO:0005216 ion channel activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.38323 BP_3 437.39 8.94 2651 642938996 XP_008200109.1 1050 3.0e-111 PREDICTED: serine protease inhibitor 3/4-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 579 5.1e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38326 BP_3 1140.00 14.35 4122 642935064 XP_008199925.1 275 3.5e-21 PREDICTED: nesprin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38327 BP_3 683.00 26.52 1533 270014128 EFA10576.1 288 4.0e-23 hypothetical protein TcasGA2_TC012832 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NVR1 176 1.6e-11 Alpha-endosulfine OS=Xenopus tropicalis GN=ensa PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4076 Regulator of ATP-sensitive K+ channels Alpha-endosulfine/ARPP-19 and related cAMP-regulated phosphoproteins Cluster-8309.38328 BP_3 10820.08 127.41 4385 646720852 KDR22435.1 6023 0.0e+00 Clathrin heavy chain [Zootermopsis nevadensis] 347969081 XM_003436308.1 2014 0 Anopheles gambiae str. PEST AGAP003021-PB (AgaP_AGAP003021) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 5834 0.0e+00 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF01736//PF00231//PF09268//PF00515//PF04053//PF00637//PF13176//PF12937 Polyomavirus agnoprotein//ATP synthase//Clathrin, heavy-chain linker//Tetratricopeptide repeat//Coatomer WD associated region//Region in Clathrin and VPS//Tetratricopeptide repeat//F-box-like GO:0006119//GO:0006886//GO:0016192//GO:0015986//GO:0015992 oxidative phosphorylation//intracellular protein transport//vesicle-mediated transport//ATP synthesis coupled proton transport//proton transport GO:0003677//GO:0005198//GO:0005515//GO:0046933//GO:0046961 DNA binding//structural molecule activity//protein binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism GO:0030132//GO:0045261//GO:0045259//GO:0030130//GO:0030117 clathrin coat of coated pit//proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex//clathrin coat of trans-Golgi network vesicle//membrane coat KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.38329 BP_3 241.52 2.80 4449 568253675 ETN62753.1 4297 0.0e+00 clathrin heavy chain [Anopheles darlingi] 347969081 XM_003436308.1 1421 0 Anopheles gambiae str. PEST AGAP003021-PB (AgaP_AGAP003021) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 4162 0.0e+00 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF01736//PF00515//PF04053//PF00637//PF13176//PF12937//PF00231 Polyomavirus agnoprotein//Tetratricopeptide repeat//Coatomer WD associated region//Region in Clathrin and VPS//Tetratricopeptide repeat//F-box-like//ATP synthase GO:0015992//GO:0015986//GO:0006886//GO:0016192//GO:0006119 proton transport//ATP synthesis coupled proton transport//intracellular protein transport//vesicle-mediated transport//oxidative phosphorylation GO:0046961//GO:0046933//GO:0005515//GO:0005198//GO:0003677 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism//protein binding//structural molecule activity//DNA binding GO:0030117//GO:0045259//GO:0045261 membrane coat//proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.38331 BP_3 188.80 3.03 3299 642932518 XP_008197147.1 2554 1.5e-285 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B isoform X3 [Tribolium castaneum] 642932517 XM_008198925.1 575 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03043 2078 9.7e-232 cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster GN=for PE=1 SV=3 PF17082//PF00069//PF07714 Spindle Pole Component 29//Protein kinase domain//Protein tyrosine kinase GO:0030474//GO:0006468 spindle pole body duplication//protein phosphorylation GO:0005524//GO:0005200//GO:0004672 ATP binding//structural constituent of cytoskeleton//protein kinase activity GO:0005856//GO:0005823 cytoskeleton//central plaque of spindle pole body KOG0614 cGMP-dependent protein kinase Cluster-8309.38333 BP_3 499.63 5.49 4679 270008875 EFA05323.1 1281 8.8e-138 hypothetical protein TcasGA2_TC015481 [Tribolium castaneum] 110431373 NM_001042570.1 306 1.67267e-156 Tribolium castaneum chitinase 7 (Cht7), mRNA >gnl|BL_ORD_ID|3159255 Tribolium castaneum chitinase 7 mRNA, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 491 1.5e-47 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF01607//PF00704 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18 GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region KOG2806 Chitinase Cluster-8309.38334 BP_3 126.32 8.18 1036 642925814 XP_970128.3 541 1.2e-52 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 370 3.5e-34 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF00106//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- -- -- Cluster-8309.38335 BP_3 1258.25 7.08 8859 642930846 XP_008196111.1 677 1.8e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38338 BP_3 794.99 9.65 4262 91080099 XP_966636.1 490 4.2e-46 PREDICTED: tumor protein p53-inducible nuclear protein 2 [Tribolium castaneum]>gi|270004657|gb|EFA01105.1| hypothetical protein TcasGA2_TC004030 [Tribolium castaneum] 642918603 XM_961543.3 73 5.08777e-27 PREDICTED: Tribolium castaneum tumor protein p53-inducible nuclear protein 2 (LOC655048), mRNA K15310 TP53INP1 tumor protein p53-inducible nuclear protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15310 Q9QXE4 193 4.8e-13 Tumor protein p53-inducible nuclear protein 1 OS=Mus musculus GN=Trp53inp1 PE=2 SV=1 PF10034 Q-cell neuroblast polarisation -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38339 BP_3 161.37 1.28 6367 642918882 XP_008191626.1 1989 9.5e-220 PREDICTED: E3 ubiquitin-protein ligase TRIM33-like [Tribolium castaneum] 817217743 XM_012429361.1 488 0 PREDICTED: Orussus abietinus serine/threonine-protein kinase minibrain (LOC105702083), transcript variant X2, mRNA K08825 DYRK1 dual specificity tyrosine-phosphorylation-regulated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08825 P49657 1840 7.4e-204 Serine/threonine-protein kinase minibrain OS=Drosophila melanogaster GN=mnb PE=2 SV=2 PF06180//PF07714//PF00069//PF01399 Cobalt chelatase (CbiK)//Protein tyrosine kinase//Protein kinase domain//PCI domain GO:0019251//GO:0006783//GO:0006468 anaerobic cobalamin biosynthetic process//heme biosynthetic process//protein phosphorylation GO:0005524//GO:0004672//GO:0005515//GO:0016852 ATP binding//protein kinase activity//protein binding//sirohydrochlorin cobaltochelatase activity -- -- KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.38340 BP_3 3391.00 62.52 2906 546676886 ERL87810.1 2010 1.6e-222 hypothetical protein D910_05199 [Dendroctonus ponderosae] -- -- -- -- -- K07611 LMNB lamin B http://www.genome.jp/dbget-bin/www_bget?ko:K07611 P08928 1438 1.4e-157 Lamin Dm0 OS=Drosophila melanogaster GN=Lam PE=1 SV=4 PF00038//PF05478 Intermediate filament protein//Prominin -- -- GO:0005198 structural molecule activity GO:0016021//GO:0005882 integral component of membrane//intermediate filament KOG0977 Nuclear envelope protein lamin, intermediate filament superfamily Cluster-8309.38341 BP_3 976.00 37.84 1535 226968614 YP_002808563.1 1895 1.8e-209 cytochrome c oxidase subunit I [Scylla paramamosain]>gi|225697850|gb|ACO07217.1| cytochrome c oxidase subunit I [Scylla paramamosain]>gi|403311089|gb|AFR34048.1| cytochrome c oxidase subunit I (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 1509 0 Scylla paramamosain mitochondrion, complete genome K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00399 1669 1.2e-184 Cytochrome c oxidase subunit 1 OS=Drosophila melanogaster GN=mt:CoI PE=2 SV=2 -- -- GO:0006118//GO:0022900//GO:0015992//GO:0006123//GO:0009060//GO:0006119 obsolete electron transport//electron transport chain//proton transport//mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration//oxidative phosphorylation GO:0009055//GO:0020037//GO:0004129//GO:0005506 electron carrier activity//heme binding//cytochrome-c oxidase activity//iron ion binding GO:0016021//GO:0070469//GO:0005743//GO:0045277 integral component of membrane//respiratory chain//mitochondrial inner membrane//respiratory chain complex IV KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.38342 BP_3 1127.39 39.98 1651 642915524 XP_008190651.1 1664 1.2e-182 PREDICTED: transmembrane protein 184B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2VDL9 1125 1.6e-121 Transmembrane protein 184B OS=Bos taurus GN=TMEM184B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.38344 BP_3 1201.82 8.85 6838 642916281 XP_008190958.1 3513 0.0e+00 PREDICTED: NFX1-type zinc finger-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R151 1145 3.1e-123 NFX1-type zinc finger-containing protein 1 OS=Mus musculus GN=Znfx1 PE=2 SV=3 PF00270//PF00769//PF07926//PF04851//PF09726//PF02562//PF01920//PF00004//PF00170//PF07728//PF01695//PF04977 DEAD/DEAH box helicase//Ezrin/radixin/moesin family//TPR/MLP1/MLP2-like protein//Type III restriction enzyme, res subunit//Transmembrane protein//PhoH-like protein//Prefoldin subunit//ATPase family associated with various cellular activities (AAA)//bZIP transcription factor//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Septum formation initiator GO:0007049//GO:0006606//GO:0006355//GO:0006457 cell cycle//protein import into nucleus//regulation of transcription, DNA-templated//protein folding GO:0016787//GO:0005524//GO:0003700//GO:0016887//GO:0043565//GO:0051082//GO:0003677//GO:0008092//GO:0003676 hydrolase activity//ATP binding//transcription factor activity, sequence-specific DNA binding//ATPase activity//sequence-specific DNA binding//unfolded protein binding//DNA binding//cytoskeletal protein binding//nucleic acid binding GO:0019898//GO:0016021//GO:0005737//GO:0016272//GO:0005667 extrinsic component of membrane//integral component of membrane//cytoplasm//prefoldin complex//transcription factor complex KOG1807 Helicases Cluster-8309.38346 BP_3 24.41 0.33 3817 642937750 XP_008198931.1 1242 2.4e-133 PREDICTED: GRAM domain-containing protein 3-like isoform X3 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.30196e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q3KR37 272 2.9e-22 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 PF01277 Oleosin -- -- -- -- GO:0016021//GO:0012511 integral component of membrane//monolayer-surrounded lipid storage body KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.38348 BP_3 2134.93 233.72 732 557798908 AHA36969.1 920 9.9e-97 heat shock protein 70b [Leptinotarsa decemlineata] 850325561 XM_004716450.2 134 1.03517e-61 PREDICTED: Echinops telfairi heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5), mRNA K09490 HSPA5, BIP heat shock 70kDa protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09490 P29844 854 1.8e-90 Heat shock 70 kDa protein cognate 3 OS=Drosophila melanogaster GN=Hsc70-3 PE=2 SV=2 PF06723//PF01791 MreB/Mbl protein//DeoC/LacD family aldolase GO:0000902 cell morphogenesis GO:0016829 lyase activity -- -- KOG0100 Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily Cluster-8309.38349 BP_3 100.33 1.39 3777 270014227 EFA10675.1 3301 0.0e+00 kinesin heavy chain [Tribolium castaneum] 642936643 XM_008200299.1 791 0 PREDICTED: Tribolium castaneum kinesin 1 (LOC662208), mRNA K10396 KIF5 kinesin family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10396 P17210 2745 5.0e-309 Kinesin heavy chain OS=Drosophila melanogaster GN=Khc PE=1 SV=2 PF04111//PF01601//PF00225//PF05557//PF00769//PF08702//PF15461 Autophagy protein Apg6//Coronavirus S2 glycoprotein//Kinesin motor domain//Mitotic checkpoint protein//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Beta-carotene 15,15'-dioxygenase GO:0007165//GO:0007018//GO:0051258//GO:0006914//GO:0007017//GO:0055114//GO:0030168//GO:0061025//GO:0007094//GO:0046813 signal transduction//microtubule-based movement//protein polymerization//autophagy//microtubule-based process//oxidation-reduction process//platelet activation//membrane fusion//mitotic spindle assembly checkpoint//receptor-mediated virion attachment to host cell GO:0005524//GO:0016702//GO:0005102//GO:0008092//GO:0003777//GO:0008017//GO:0030674 ATP binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//receptor binding//cytoskeletal protein binding//microtubule motor activity//microtubule binding//protein binding, bridging GO:0016021//GO:0019898//GO:0045298//GO:0005737//GO:0005577//GO:0019031//GO:0005874 integral component of membrane//extrinsic component of membrane//tubulin complex//cytoplasm//fibrinogen complex//viral envelope//microtubule KOG0240 Kinesin (SMY1 subfamily) Cluster-8309.3835 BP_3 8.00 0.41 1229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38350 BP_3 38.40 0.50 3982 270014227 EFA10675.1 850 7.1e-88 kinesin heavy chain [Tribolium castaneum] -- -- -- -- -- K10396 KIF5 kinesin family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10396 P17210 732 1.4e-75 Kinesin heavy chain OS=Drosophila melanogaster GN=Khc PE=1 SV=2 PF16519//PF17078//PF03999//PF07926//PF05384//PF07989//PF10473//PF10186//PF07851//PF04111//PF06156 Tetramerisation domain of TRPM//SWI5-dependent HO expression protein 3//Microtubule associated protein (MAP65/ASE1 family)//TPR/MLP1/MLP2-like protein//Sensor protein DegS//Centrosomin N-terminal motif 1//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Vacuolar sorting 38 and autophagy-related subunit 14//TMPIT-like protein//Autophagy protein Apg6//Protein of unknown function (DUF972) GO:0051028//GO:0048309//GO:0000910//GO:0000226//GO:0006914//GO:0051262//GO:0007165//GO:0010508//GO:0006606//GO:0006260 mRNA transport//endoplasmic reticulum inheritance//cytokinesis//microtubule cytoskeleton organization//autophagy//protein tetramerization//signal transduction//positive regulation of autophagy//protein import into nucleus//DNA replication GO:0042803//GO:0008017//GO:0045502//GO:0008134//GO:0016301 protein homodimerization activity//microtubule binding//dynein binding//transcription factor binding//kinase activity GO:0005667//GO:0030286//GO:0045298//GO:0016021//GO:0005815 transcription factor complex//dynein complex//tubulin complex//integral component of membrane//microtubule organizing center KOG0240 Kinesin (SMY1 subfamily) Cluster-8309.38351 BP_3 45.17 0.58 4034 270010524 EFA06972.1 1110 5.1e-118 hypothetical protein TcasGA2_TC009932 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI7 662 1.9e-67 Upstream-binding protein 1 OS=Homo sapiens GN=UBP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.38352 BP_3 300.00 9.51 1813 91080577 XP_973491.1 1825 2.8e-201 PREDICTED: transmembrane protein 87A [Tribolium castaneum]>gi|642919365|ref|XP_008191841.1| PREDICTED: transmembrane protein 87A [Tribolium castaneum]>gi|642919367|ref|XP_008191842.1| PREDICTED: transmembrane protein 87A [Tribolium castaneum]>gi|270005808|gb|EFA02256.1| hypothetical protein TcasGA2_TC007919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28EW0 981 8.5e-105 Transmembrane protein 87A OS=Xenopus tropicalis GN=tmem87a PE=2 SV=1 PF06814 Lung seven transmembrane receptor -- -- -- -- GO:0016021 integral component of membrane KOG2568 Predicted membrane protein Cluster-8309.38353 BP_3 459.47 5.05 4674 642928151 XP_008200178.1 3675 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 1A isoform X1 [Tribolium castaneum] -- -- -- -- -- K11655 BAZ1A, ACF1 bromodomain adjacent to zinc finger domain protein 1A http://www.genome.jp/dbget-bin/www_bget?ko:K11655 Q9NRL2 535 1.1e-52 Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens GN=BAZ1A PE=1 SV=2 PF00439//PF00628 Bromodomain//PHD-finger -- -- GO:0005515 protein binding -- -- KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.38354 BP_3 388.10 7.13 2917 91091412 XP_973980.1 497 4.4e-47 PREDICTED: cAMP-responsive element-binding protein-like 2 [Tribolium castaneum]>gi|270014172|gb|EFA10620.1| hypothetical protein TcasGA2_TC012882 [Tribolium castaneum] 751781411 XM_011201569.1 47 9.85058e-13 PREDICTED: Bactrocera dorsalis cAMP-responsive element-binding protein-like 2 (LOC105223754), mRNA -- -- -- -- A4IGK3 291 1.4e-24 cAMP-responsive element-binding protein-like 2 OS=Xenopus tropicalis GN=crebl2 PE=3 SV=1 PF01694//PF00170//PF07716 Rhomboid family//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0004252 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//serine-type endopeptidase activity GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG2289 Rhomboid family proteins Cluster-8309.38357 BP_3 2752.60 10.04 13511 478258629 ENN78679.1 7005 0.0e+00 hypothetical protein YQE_04851, partial [Dendroctonus ponderosae]>gi|546685785|gb|ERL95234.1| hypothetical protein D910_12501 [Dendroctonus ponderosae] 665784642 XM_008562939.1 64 1.63317e-21 PREDICTED: Microplitis demolitor synaptobrevin homolog YKT6 (LOC103580980), mRNA K05732 GRLF1 glucocorticoid receptor DNA-binding factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05732 Q9VX32 2839 0.0e+00 Rho GTPase-activating protein 190 OS=Drosophila melanogaster GN=RhoGAPp190 PE=1 SV=2 PF00620//PF00957//PF00642//PF08911//PF00071//PF10403//PF01207 RhoGAP domain//Synaptobrevin//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//NUP50 (Nucleoporin 50 kDa)//Ras family//Rad4 beta-hairpin domain 1//Dihydrouridine synthase (Dus) GO:0008033//GO:0055114//GO:0007264//GO:0016192//GO:0007165 tRNA processing//oxidation-reduction process//small GTPase mediated signal transduction//vesicle-mediated transport//signal transduction GO:0046872//GO:0050660//GO:0005525//GO:0017150//GO:0003677 metal ion binding//flavin adenine dinucleotide binding//GTP binding//tRNA dihydrouridine synthase activity//DNA binding GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG2333 Uncharacterized conserved protein Cluster-8309.38358 BP_3 17255.35 1859.46 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38359 BP_3 310.15 6.79 2492 642927244 XP_974103.2 1078 1.6e-114 PREDICTED: stromal membrane-associated protein 1-like [Tribolium castaneum] -- -- -- -- -- K12486 SMAP stromal membrane-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K12486 Q5EA00 525 8.8e-52 Stromal membrane-associated protein 2 OS=Bos taurus GN=SMAP2 PE=2 SV=1 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0703 Predicted GTPase-activating protein Cluster-8309.38360 BP_3 53.11 3.33 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38365 BP_3 211.00 2.61 4195 642931877 XP_008196766.1 291 4.9e-23 PREDICTED: casein kinase I isoform delta-A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38366 BP_3 38.47 0.42 4689 642926472 XP_008191972.1 1172 3.8e-125 PREDICTED: flotillin-2 isoform X2 [Tribolium castaneum]>gi|642926474|ref|XP_008191973.1| PREDICTED: flotillin-2 isoform X2 [Tribolium castaneum] 645037638 XM_008207769.1 245 1.36163e-122 PREDICTED: Nasonia vitripennis flotillin-2 (LOC103316081), mRNA K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61492 1067 2.4e-114 Flotillin-2 OS=Drosophila melanogaster GN=Flo-2 PE=2 SV=3 PF12052 Voltage gated calcium channel subunit beta domain 4Aa N terminal GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005245 voltage-gated calcium channel activity GO:0005891 voltage-gated calcium channel complex -- -- Cluster-8309.38367 BP_3 1273.56 9.16 6992 642931879 XP_972641.2 1968 2.9e-217 PREDICTED: casein kinase I isoform delta-A isoform X2 [Tribolium castaneum] 642931878 XM_967548.3 364 0 PREDICTED: Tribolium castaneum casein kinase I isoform delta-A (LOC661388), transcript variant X2, mRNA K08959 CSNK1D casein kinase 1, delta http://www.genome.jp/dbget-bin/www_bget?ko:K08959 Q9DC28 1532 4.2e-168 Casein kinase I isoform delta OS=Mus musculus GN=Csnk1d PE=1 SV=2 PF00069//PF07714//PF05445 Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.38368 BP_3 6533.04 173.75 2104 332374576 AEE62429.1 1425 7.9e-155 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 284 1.26544e-144 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1286 4.3e-140 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding -- -- -- -- Cluster-8309.38370 BP_3 5574.12 172.75 1847 195341714 XP_002037451.1 218 6.3e-15 GM12097 [Drosophila sechellia]>gi|194131567|gb|EDW53610.1| GM12097 [Drosophila sechellia]>gi|900917488|gb|KMZ06990.1| uncharacterized protein Dsimw501_GD16524, isoform B [Drosophila simulans]>gi|900917489|gb|KMZ06991.1| uncharacterized protein Dsimw501_GD16524, isoform C [Drosophila simulans]>gi|900917490|gb|KMZ06992.1| uncharacterized protein Dsimw501_GD16524, isoform D [Drosophila simulans]>gi|900917491|gb|KMZ06993.1| uncharacterized protein Dsimw501_GD16524, isoform E [Drosophila simulans] 642937681 XM_008200677.1 165 1.57172e-78 PREDICTED: Tribolium castaneum ATP synthase lipid-binding protein, mitochondrial (LOC655995), transcript variant X2, mRNA K02128 ATPeF0C, ATP5G, ATP9 F-type H+-transporting ATPase subunit c http://www.genome.jp/dbget-bin/www_bget?ko:K02128 P07926 204 1.1e-14 ATP synthase F(0) complex subunit C2, mitochondrial OS=Bos taurus GN=ATP5G2 PE=1 SV=1 PF00137//PF02703 ATP synthase subunit C//Early E1A protein GO:0015992//GO:0006810//GO:0015991//GO:0019048//GO:0006355 proton transport//transport//ATP hydrolysis coupled proton transport//modulation by virus of host morphology or physiology//regulation of transcription, DNA-templated GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.38371 BP_3 2953.53 36.47 4195 646701001 KDR10924.1 2056 1.1e-227 ATP-dependent RNA helicase DDX3X [Zootermopsis nevadensis] 237681148 NM_001160249.1 491 0 Tribolium castaneum ATP-dependent RNA helicase belle (belle), mRNA K11594 DDX3X, bel ATP-dependent RNA helicase DDX3X http://www.genome.jp/dbget-bin/www_bget?ko:K11594 Q9VHP0 1729 3.6e-191 ATP-dependent RNA helicase bel OS=Drosophila melanogaster GN=bel PE=1 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003676//GO:0016787//GO:0003677 ATP binding//nucleic acid binding//hydrolase activity//DNA binding -- -- KOG0335 ATP-dependent RNA helicase Cluster-8309.38372 BP_3 166.16 4.84 1947 642918472 XP_971273.2 1504 5.0e-164 PREDICTED: protein NDRG3 isoform X3 [Tribolium castaneum] 462464055 APGK01005064.1 69 3.8531e-25 Dendroctonus ponderosae Seq01005066, whole genome shotgun sequence -- -- -- -- Q5RA95 642 1.9e-65 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.38373 BP_3 127.46 12.38 788 332374846 AEE62564.1 346 3.9e-30 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 252 1.3e-20 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106//PF01073//PF01370 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008210//GO:0008152//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.38375 BP_3 261.53 2.93 4596 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.64307e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 2.0e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186 Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy -- -- -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.38379 BP_3 1218.30 10.58 5840 91091506 XP_969096.1 3532 0.0e+00 PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|642936851|ref|XP_008197901.1| PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|270000934|gb|EEZ97381.1| hypothetical protein TcasGA2_TC011206 [Tribolium castaneum] 170030268 XM_001842960.1 189 2.29235e-91 Culex quinquefasciatus ubiquitin-protein ligase E3A, mRNA K10587 UBE3A, E6AP ubiquitin-protein ligase E3 A http://www.genome.jp/dbget-bin/www_bget?ko:K10587 Q05086 2156 1.6e-240 Ubiquitin-protein ligase E3A OS=Homo sapiens GN=UBE3A PE=1 SV=4 PF15798//PF00895//PF00632 Proline-rich AKT1 substrate 1//ATP synthase protein 8//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0048011//GO:0015992//GO:0032007//GO:0015986 protein ubiquitination//neurotrophin TRK receptor signaling pathway//proton transport//negative regulation of TOR signaling//ATP synthesis coupled proton transport GO:0004842//GO:0015078 ubiquitin-protein transferase activity//hydrogen ion transmembrane transporter activity GO:0000276//GO:0005622 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//intracellular KOG0941 E3 ubiquitin protein ligase Cluster-8309.38380 BP_3 410.30 4.37 4819 478252421 ENN72845.1 503 1.5e-47 hypothetical protein YQE_10525, partial [Dendroctonus ponderosae]>gi|546677840|gb|ERL88597.1| hypothetical protein D910_05982 [Dendroctonus ponderosae] 642919574 XM_970177.2 87 9.50039e-35 PREDICTED: Tribolium castaneum calcineurin subunit B type 2 (LOC664163), mRNA K06268 PPP3R, CNB serine/threonine-protein phosphatase 2B regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06268 P48451 487 4.4e-47 Calcineurin subunit B type 1 OS=Drosophila melanogaster GN=CanB PE=2 SV=1 PF13405//PF13833//PF00036//PF13499//PF13202//PF12763 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.38382 BP_3 1479.95 18.04 4245 91084825 XP_973466.1 1748 5.6e-192 PREDICTED: GAS2-like protein 2 [Tribolium castaneum]>gi|642925938|ref|XP_008194703.1| PREDICTED: GAS2-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZP9 712 3.1e-73 GAS2-like protein 1 OS=Mus musculus GN=Gas2l1 PE=2 SV=1 PF00307//PF02187 Calponin homology (CH) domain//Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.38384 BP_3 985.05 30.51 1848 189237914 XP_969710.2 1350 3.5e-146 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] -- -- -- -- -- K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q06190 154 6.9e-09 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha OS=Homo sapiens GN=PPP2R3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38387 BP_3 17708.99 86.72 10134 156564242 NP_001096047.1 2302 7.7e-256 chitin deacetylase 2 isoform A precursor [Tribolium castaneum]>gi|155675832|gb|ABU25224.1| chitin deacetylase 2A [Tribolium castaneum] 332374221 BT127290.1 543 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA -- -- -- -- O16011 733 2.7e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF01522//PF01607//PF00642//PF00057 MMPL family//Polysaccharide deacetylase//Chitin binding Peritrophin-A domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Low-density lipoprotein receptor domain class A GO:0006030//GO:0006040//GO:0005975//GO:0006807 chitin metabolic process//amino sugar metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0005515//GO:0046872//GO:0004099//GO:0016810//GO:0008061 protein binding//metal ion binding//chitin deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0016020//GO:0005576 membrane//extracellular region KOG2494 C3H1-type Zn-finger protein Cluster-8309.38388 BP_3 835.16 11.89 3678 332376995 AEE63637.1 1603 3.2e-175 unknown [Dendroctonus ponderosae]>gi|478252044|gb|ENN72475.1| hypothetical protein YQE_10817, partial [Dendroctonus ponderosae] 768439449 XM_011563053.1 208 3.94323e-102 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K04712 DEGS sphingolipid delta-4 desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K04712 Q3ZBY7 1091 3.0e-117 Sphingolipid delta(4)-desaturase DES1 OS=Bos taurus GN=DEGS1 PE=2 SV=1 PF00887//PF00487 Acyl CoA binding protein//Fatty acid desaturase GO:0006629 lipid metabolic process GO:0000062 fatty-acyl-CoA binding -- -- KOG2987 Fatty acid desaturase Cluster-8309.38389 BP_3 183.00 3.86 2576 189238706 XP_001811763.1 1575 3.9e-172 PREDICTED: calcium-independent phospholipase A2-gamma-like [Tribolium castaneum] -- -- -- -- -- K16815 PNPLA8 calcium-independent phospholipase A2-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16815 Q5XTS1 984 5.5e-105 Calcium-independent phospholipase A2-gamma OS=Oryctolagus cuniculus GN=PNPLA8 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.38390 BP_3 2363.25 39.99 3140 642915765 XP_008200071.1 1069 2.2e-113 PREDICTED: zinc finger protein ubi-d4 B-like [Tribolium castaneum] 641653063 XM_003241514.2 58 8.14656e-19 PREDICTED: Acyrthosiphon pisum zinc finger protein ubi-d4 (LOC100161288), transcript variant X3, mRNA K13196 DPF2, REQ zinc finger protein ubi-d4 http://www.genome.jp/dbget-bin/www_bget?ko:K13196 Q9W638 366 3.0e-33 Zinc finger protein ubi-d4 A OS=Xenopus laevis GN=req-a PE=2 SV=1 PF00096//PF00628//PF02064//PF16866 Zinc finger, C2H2 type//PHD-finger//MAS20 protein import receptor//PHD-finger GO:0006886//GO:0006605 intracellular protein transport//protein targeting GO:0005515//GO:0046872 protein binding//metal ion binding GO:0005742 mitochondrial outer membrane translocase complex KOG1244 Predicted transcription factor Requiem/NEURO-D4 Cluster-8309.38392 BP_3 139.05 1.64 4390 642918838 XP_008191608.1 2788 0.0e+00 PREDICTED: breast carcinoma-amplified sequence 3 homolog isoform X1 [Tribolium castaneum] 642918837 XM_008193386.1 258 7.56055e-130 PREDICTED: Tribolium castaneum breast carcinoma-amplified sequence 3 homolog (LOC661755), transcript variant X1, mRNA -- -- -- -- Q8SY41 1526 1.3e-167 Breast carcinoma-amplified sequence 3 homolog OS=Drosophila melanogaster GN=rudhira PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2109 WD40 repeat protein Cluster-8309.38394 BP_3 145.24 0.73 9831 332373526 AEE61904.1 1287 3.7e-138 unknown [Dendroctonus ponderosae]>gi|478254046|gb|ENN74338.1| hypothetical protein YQE_09308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBX0 654 3.8e-66 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF05706//PF01728//PF03435//PF01370//PF00106//PF01073 Cyclin-dependent kinase inhibitor 3 (CDKN3)//FtsJ-like methyltransferase//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0006570//GO:0055114//GO:0006694//GO:0008209//GO:0008207//GO:0006470//GO:0008210//GO:0008152//GO:0032259 tyrosine metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process//protein dephosphorylation//estrogen metabolic process//metabolic process//methylation GO:0016616//GO:0003854//GO:0050662//GO:0008168//GO:0004725//GO:0016491//GO:0003824//GO:0004721 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//methyltransferase activity//protein tyrosine phosphatase activity//oxidoreductase activity//catalytic activity//phosphoprotein phosphatase activity -- -- KOG2733 Uncharacterized membrane protein Cluster-8309.38395 BP_3 3673.40 46.61 4090 189241616 XP_966968.2 953 8.3e-100 PREDICTED: cyclic AMP response element-binding protein A-like isoform X3 [Tribolium castaneum] 195590478 XM_002084937.1 97 2.22308e-40 Drosophila simulans GD14552 (Dsim\GD14552), mRNA K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 P29747 388 1.1e-35 Cyclic AMP response element-binding protein A OS=Drosophila melanogaster GN=CrebA PE=1 SV=2 PF04111//PF01544//PF00170//PF06005//PF03131//PF07926//PF02183//PF07716 Autophagy protein Apg6//CorA-like Mg2+ transporter protein//bZIP transcription factor//Protein of unknown function (DUF904)//bZIP Maf transcription factor//TPR/MLP1/MLP2-like protein//Homeobox associated leucine zipper//Basic region leucine zipper GO:0000917//GO:0043093//GO:0006606//GO:0006355//GO:0006914//GO:0030001//GO:0055085 barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//regulation of transcription, DNA-templated//autophagy//metal ion transport//transmembrane transport GO:0003700//GO:0043565//GO:0046873//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//metal ion transmembrane transporter activity//DNA binding GO:0005737//GO:0016020//GO:0005667//GO:0005634 cytoplasm//membrane//transcription factor complex//nucleus KOG0709 CREB/ATF family transcription factor Cluster-8309.38396 BP_3 3177.83 71.87 2423 642921511 XP_008192900.1 2876 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECTD1 [Tribolium castaneum] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q9ULT8 1759 7.0e-195 E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens GN=HECTD1 PE=1 SV=3 PF02747//PF00632 Proliferating cell nuclear antigen, C-terminal domain//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0006275 protein ubiquitination//regulation of DNA replication GO:0004842//GO:0003677 ubiquitin-protein transferase activity//DNA binding -- -- KOG0170 E3 ubiquitin protein ligase Cluster-8309.38399 BP_3 2536.40 38.67 3453 189235332 XP_001816025.1 646 2.8e-64 PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Tribolium castaneum]>gi|270003646|gb|EFA00094.1| hypothetical protein TcasGA2_TC002909 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF00822//PF13903//PF10204//PF04226 Ligand-gated ion channel//PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction//Dual oxidase maturation factor//Transglycosylase associated protein GO:0015031//GO:0006811//GO:0007268//GO:0007165 protein transport//ion transport//synaptic transmission//signal transduction GO:0004970 ionotropic glutamate receptor activity GO:0016020//GO:0016021//GO:0005789 membrane//integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.384 BP_3 68.00 2.37 1677 759073837 XP_011346583.1 227 5.2e-16 PREDICTED: LOW QUALITY PROTEIN: trihelix transcription factor GT-1-like [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38400 BP_3 34.00 0.50 3548 189235332 XP_001816025.1 646 2.8e-64 PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Tribolium castaneum]>gi|270003646|gb|EFA00094.1| hypothetical protein TcasGA2_TC002909 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13903//PF04226//PF10204//PF00822//PF00060 PMP-22/EMP/MP20/Claudin tight junction//Transglycosylase associated protein//Dual oxidase maturation factor//PMP-22/EMP/MP20/Claudin family//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0015031//GO:0006811 signal transduction//synaptic transmission//protein transport//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0005789//GO:0016021//GO:0016020 endoplasmic reticulum membrane//integral component of membrane//membrane -- -- Cluster-8309.38402 BP_3 16.87 0.34 2706 642927984 XP_008195472.1 731 3.0e-74 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38403 BP_3 13.25 0.38 1965 642927984 XP_008195472.1 728 4.9e-74 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38404 BP_3 19.25 0.40 2629 642912272 XP_008200632.1 785 1.6e-80 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 6.5e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF01414//PF00089//PF15965 Delta serrate ligand//Trypsin//TRAF-like zinc-finger GO:0007154//GO:0006508 cell communication//proteolysis GO:0004252//GO:0008270 serine-type endopeptidase activity//zinc ion binding GO:0016020 membrane -- -- Cluster-8309.38405 BP_3 77.63 0.40 9646 270005301 EFA01749.1 185 2.2e-10 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 159 9.4e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF09728//PF05485//PF01708//PF02892//PF01533//PF04608//PF00096 Myosin-like coiled-coil protein//THAP domain//Geminivirus putative movement protein//BED zinc finger//Tospovirus nucleocapsid protein//Phosphatidylglycerophosphatase A//Zinc finger, C2H2 type GO:0006629//GO:0046740//GO:0046486 lipid metabolic process//transport of virus in host, cell to cell//glycerolipid metabolic process GO:0003677//GO:0019905//GO:0003676//GO:0008962//GO:0046872 DNA binding//syntaxin binding//nucleic acid binding//phosphatidylglycerophosphatase activity//metal ion binding GO:0016021//GO:0019013 integral component of membrane//viral nucleocapsid -- -- Cluster-8309.38406 BP_3 1470.86 8.43 8700 478258659 ENN78709.1 2012 2.8e-222 hypothetical protein YQE_04881, partial [Dendroctonus ponderosae] 478512620 XM_004430515.1 38 2.98211e-07 PREDICTED: Ceratotherium simum simum death inducer-obliterator 1 (DIDO1), mRNA -- -- -- -- Q8BFT6 770 1.2e-79 JmjC domain-containing protein 4 OS=Mus musculus GN=Jmjd4 PE=2 SV=1 PF07500//PF00628//PF07533//PF06427 Transcription factor S-II (TFIIS), central domain//PHD-finger//BRK domain//UDP-glucose:Glycoprotein Glucosyltransferase GO:0006351//GO:0006486 transcription, DNA-templated//protein glycosylation GO:0016817//GO:0003980//GO:0005515 hydrolase activity, acting on acid anhydrides//UDP-glucose:glycoprotein glucosyltransferase activity//protein binding -- -- KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.38409 BP_3 75.70 0.72 5361 270004778 EFA01226.1 1946 7.8e-215 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1414 1.6e-154 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38412 BP_3 212.40 4.34 2653 642931533 XP_008196625.1 1374 8.2e-149 PREDICTED: WW domain-containing oxidoreductase [Tribolium castaneum] -- -- -- -- -- K19329 WWOX WW domain-containing oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K19329 Q9VLU5 985 4.3e-105 WW domain-containing oxidoreductase OS=Drosophila melanogaster GN=Wwox PE=2 SV=1 PF00397//PF00106 WW domain//short chain dehydrogenase GO:0008152 metabolic process GO:0005515//GO:0016491 protein binding//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.38415 BP_3 250.31 1.43 8728 642930342 XP_008196356.1 5278 0.0e+00 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 1112 0 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- P35580 408 1.1e-37 Myosin-10 OS=Homo sapiens GN=MYH10 PE=1 SV=3 PF06156//PF05550//PF16331//PF00901//PF10174//PF07195//PF10473//PF07989//PF03836//PF02183//PF08657//PF00769 Protein of unknown function (DUF972)//Pestivirus Npro endopeptidase C53//TolA binding protein trimerisation//Orbivirus outer capsid protein VP5//RIM-binding protein of the cytomatrix active zone//Flagellar hook-associated protein 2 C-terminus//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//RasGAP C-terminus//Homeobox associated leucine zipper//DASH complex subunit Spc34//Ezrin/radixin/moesin family GO:0006260//GO:0008608//GO:0019082//GO:0006355//GO:0070206//GO:0007264//GO:0007155//GO:0016032 DNA replication//attachment of spindle microtubules to kinetochore//viral protein processing//regulation of transcription, DNA-templated//protein trimerization//small GTPase mediated signal transduction//cell adhesion//viral process GO:0003700//GO:0043565//GO:0008134//GO:0045502//GO:0005198//GO:0005096//GO:0042803//GO:0008092 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//transcription factor binding//dynein binding//structural molecule activity//GTPase activator activity//protein homodimerization activity//cytoskeletal protein binding GO:0005876//GO:0005737//GO:0009288//GO:0048786//GO:0042729//GO:0019028//GO:0005815//GO:0019898//GO:0005667//GO:0030286 spindle microtubule//cytoplasm//bacterial-type flagellum//presynaptic active zone//DASH complex//viral capsid//microtubule organizing center//extrinsic component of membrane//transcription factor complex//dynein complex -- -- Cluster-8309.38417 BP_3 829.66 17.60 2564 478251025 ENN71506.1 1152 4.4e-123 hypothetical protein YQE_11799, partial [Dendroctonus ponderosae]>gi|546679474|gb|ERL89938.1| hypothetical protein D910_07297 [Dendroctonus ponderosae] -- -- -- -- -- K10052 CEBPN CCAAT/enhancer binding protein (C/EBP), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K10052 Q02637 261 3.7e-21 CCAAT/enhancer-binding protein OS=Drosophila melanogaster GN=slbo PE=1 SV=3 PF11023//PF07716//PF00170 Zinc-ribbon containing domain//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005887 transcription factor complex//integral component of plasma membrane -- -- Cluster-8309.38418 BP_3 322.22 2.09 7715 332376741 AEE63510.1 1257 8.8e-135 unknown [Dendroctonus ponderosae] 665817218 XM_008559146.1 65 2.58753e-22 PREDICTED: Microplitis demolitor glycine N-methyltransferase-like (LOC103578165), mRNA K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q29513 847 1.3e-88 Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus GN=GNMT PE=2 SV=1 PF01885//PF08241//PF01135//PF05724//PF05175//PF01909//PF06220//PF01209//PF09249//PF00076 RNA 2'-phosphotransferase, Tpt1 / KptA family//Methyltransferase domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain//Nucleotidyltransferase domain//U1 zinc finger//ubiE/COQ5 methyltransferase family//tRNA nucleotidyltransferase, second domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006464//GO:0008152//GO:0006388//GO:0006479//GO:0046500//GO:0008033 cellular protein modification process//metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//protein methylation//S-adenosylmethionine metabolic process//tRNA processing GO:0008757//GO:0004810//GO:0016437//GO:0003676//GO:0004719//GO:0008168//GO:0008270//GO:0016772//GO:0016779 S-adenosylmethionine-dependent methyltransferase activity//tRNA adenylyltransferase activity//tRNA cytidylyltransferase activity//nucleic acid binding//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//methyltransferase activity//zinc ion binding//transferase activity, transferring phosphorus-containing groups//nucleotidyltransferase activity -- -- KOG2278 RNA:NAD 2'-phosphotransferase TPT1 Cluster-8309.38419 BP_3 48.89 3.07 1060 332374348 AEE62315.1 663 9.1e-67 unknown [Dendroctonus ponderosae]>gi|478251260|gb|ENN71734.1| hypothetical protein YQE_11656, partial [Dendroctonus ponderosae]>gi|546676119|gb|ERL87186.1| hypothetical protein D910_04586 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W5U2 140 1.6e-07 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.3842 BP_3 8.00 0.34 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38420 BP_3 891.12 11.41 4055 189240845 XP_001812763.1 3538 0.0e+00 PREDICTED: AP-1 complex subunit gamma-1 isoform X1 [Tribolium castaneum] 393809286 JQ824200.1 481 0 Bombyx mori adaptor protein complex-1 gamma subunit (AP1G) mRNA, complete cds, alternatively spliced K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 2321 7.9e-260 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF01637//PF08314//PF02883//PF02985//PF04670//PF00071//PF00503//PF08367//PF01926//PF13304//PF08477//PF00025//PF01602 Archaeal ATPase//Secretory pathway protein Sec39//Adaptin C-terminal domain//HEAT repeat//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//Peptidase M16C associated//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Adaptin N terminal region GO:0006508//GO:0006890//GO:0007264//GO:0007186//GO:0007165//GO:0016192//GO:0006886 proteolysis//retrograde vesicle-mediated transport, Golgi to ER//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction//vesicle-mediated transport//intracellular protein transport GO:0004871//GO:0005525//GO:0005515//GO:0019001//GO:0031683//GO:0005524//GO:0003924 signal transducer activity//GTP binding//protein binding//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.38422 BP_3 764.28 10.55 3782 642910503 XP_008200242.1 2679 5.5e-300 PREDICTED: phospholipase DDHD2 isoform X1 [Tribolium castaneum] 826487484 XM_012683938.1 80 5.79279e-31 PREDICTED: Monomorium pharaonis SEC23-interacting protein-like (LOC105838396), transcript variant X4, mRNA -- -- -- -- Q9Y6Y8 1018 9.1e-109 SEC23-interacting protein OS=Homo sapiens GN=SEC23IP PE=1 SV=1 PF02862//PF13724 DDHD domain//DNA-binding domain -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.38424 BP_3 82.37 0.57 7306 189241670 XP_001807691.1 252 2.9e-18 PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum]>gi|642937361|ref|XP_008198805.1| PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 Q9M8S8 232 2.4e-17 Inositol-phosphate phosphatase OS=Arabidopsis thaliana GN=VTC4 PE=1 SV=1 PF05739//PF04159//PF02935//PF03664 SNARE domain//NB glycoprotein//Cytochrome c oxidase subunit VIIc//Glycosyl hydrolase family 62 GO:0006123//GO:0046373//GO:0009117//GO:0015992//GO:0005975 mitochondrial electron transport, cytochrome c to oxygen//L-arabinose metabolic process//nucleotide metabolic process//proton transport//carbohydrate metabolic process GO:0046556//GO:0005515//GO:0004129 alpha-L-arabinofuranosidase activity//protein binding//cytochrome-c oxidase activity GO:0016021//GO:0045277 integral component of membrane//respiratory chain complex IV KOG2951 Inositol monophosphatase Cluster-8309.38425 BP_3 1113.00 119.94 739 -- -- -- -- -- 170045304 XM_001850203.1 40 1.87784e-09 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF08099 Scorpion calcine family GO:0009405//GO:0006810 pathogenesis//transport GO:0019855 calcium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.38426 BP_3 591.26 2.98 9860 91085247 XP_973234.1 3413 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 316 9.76676e-162 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 2247 7.4e-251 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF06009//PF14372//PF07690//PF00083//PF02985//PF00015//PF08064//PF11698//PF05997 Laminin Domain II//Domain of unknown function (DUF4413)//Major Facilitator Superfamily//Sugar (and other) transporter//HEAT repeat//Methyl-accepting chemotaxis protein (MCP) signalling domain//UME (NUC010) domain//V-ATPase subunit H//Nucleolar protein,Nop52 GO:0007155//GO:0016310//GO:0015991//GO:0006364//GO:0009069//GO:0055085//GO:0007165 cell adhesion//phosphorylation//ATP hydrolysis coupled proton transport//rRNA processing//serine family amino acid metabolic process//transmembrane transport//signal transduction GO:0004871//GO:0005515//GO:0016820//GO:0022857//GO:0003677//GO:0004674 signal transducer activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//transmembrane transporter activity//DNA binding//protein serine/threonine kinase activity GO:0016020//GO:0000221//GO:0016021//GO:0030688 membrane//vacuolar proton-transporting V-type ATPase, V1 domain//integral component of membrane//preribosome, small subunit precursor KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.38427 BP_3 663.74 8.05 4265 546683122 ERL92973.1 1762 1.3e-193 hypothetical protein D910_10276 [Dendroctonus ponderosae] 237874246 NM_001160401.1 165 3.66706e-78 Acyrthosiphon pisum aspartyl-tRNA synthetase (Aats-asp), mRNA K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 P14868 1470 4.0e-161 Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens GN=DARS PE=1 SV=2 PF02817//PF11538//PF01409//PF02064//PF00152//PF01336 e3 binding domain//Snurportin1//tRNA synthetases class II core domain (F)//MAS20 protein import receptor//tRNA synthetases class II (D, K and N)//OB-fold nucleic acid binding domain GO:0006418//GO:0043039//GO:0006605//GO:0008152//GO:0006886 tRNA aminoacylation for protein translation//tRNA aminoacylation//protein targeting//metabolic process//intracellular protein transport GO:0000166//GO:0003676//GO:0004812//GO:0005524//GO:0016746//GO:0005515//GO:0000049 nucleotide binding//nucleic acid binding//aminoacyl-tRNA ligase activity//ATP binding//transferase activity, transferring acyl groups//protein binding//tRNA binding GO:0005737//GO:0005742 cytoplasm//mitochondrial outer membrane translocase complex KOG0556 Aspartyl-tRNA synthetase Cluster-8309.38428 BP_3 1906.96 15.15 6357 642925387 XP_008194528.1 3541 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q5XF89 2102 3.1e-234 Probable cation-transporting ATPase 13A3 OS=Mus musculus GN=Atp13a3 PE=1 SV=1 PF12409//PF00122//PF00083//PF07690 P5-type ATPase cation transporter//E1-E2 ATPase//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006812//GO:0055085 cation transport//transmembrane transport GO:0046872//GO:0000166//GO:0016887//GO:0022857 metal ion binding//nucleotide binding//ATPase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.38429 BP_3 214.74 11.95 1158 283046718 NP_001164305.1 1095 8.0e-117 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 252 4.22752e-127 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q0MQI5 987 1.1e-105 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Gorilla gorilla gorilla GN=NDUFV1 PE=2 SV=1 -- -- GO:0006744//GO:0006814//GO:0055114//GO:0015992//GO:0006120 ubiquinone biosynthetic process//sodium ion transport//oxidation-reduction process//proton transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0051539//GO:0010181//GO:0051287 NADH dehydrogenase (ubiquinone) activity//4 iron, 4 sulfur cluster binding//FMN binding//NAD binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.38430 BP_3 16.21 0.34 2569 546675642 ERL86792.1 495 6.7e-47 hypothetical protein D910_04198 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TPQ9 145 1.1e-07 Arrestin domain-containing protein 3 OS=Mus musculus GN=Arrdc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.38431 BP_3 264.69 2.01 6636 642918534 XP_008191512.1 5606 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 2813 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF16794//PF14604//PF00018//PF13895//PF00041//PF16656 Fibronectin-III type domain//Variant SH3 domain//SH3 domain//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.38432 BP_3 620.00 3.49 8844 642918912 XP_008191652.1 4654 0.0e+00 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II [Tribolium castaneum] 198473796 XM_001356410.2 231 1.56161e-114 Drosophila pseudoobscura pseudoobscura GA18269 (Dpse\GA18269), partial mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 Q9NQ66 2123 1.6e-236 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 OS=Homo sapiens GN=PLCB1 PE=1 SV=1 PF00387//PF01130//PF08703 Phosphatidylinositol-specific phospholipase C, Y domain//CD36 family//PLC-beta C terminal GO:0007155//GO:0016042//GO:0035556//GO:0007165//GO:0046339//GO:0009395//GO:0006629 cell adhesion//lipid catabolic process//intracellular signal transduction//signal transduction//diacylglycerol metabolic process//phospholipid catabolic process//lipid metabolic process GO:0005509//GO:0004435 calcium ion binding//phosphatidylinositol phospholipase C activity GO:0016020 membrane KOG1265 Phospholipase C Cluster-8309.38433 BP_3 2.32 0.39 581 642919827 XP_001814264.2 241 4.3e-18 PREDICTED: vascular endothelial growth factor A-A-like [Tribolium castaneum]>gi|270005397|gb|EFA01845.1| hypothetical protein TcasGA2_TC007448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-8309.38434 BP_3 174.17 0.89 9703 570341960 AHE77377.1 2394 1.6e-266 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 806 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2321 1.9e-259 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF02782//PF08303//PF01073//PF00106//PF05739//PF01223//PF04625//PF06723//PF00033//PF01194//PF02491//PF01370//PF01968 FGGY family of carbohydrate kinases, C-terminal domain//tRNA ligase kinase domain//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//SNARE domain//DNA/RNA non-specific endonuclease//DEC-1 protein, N-terminal region//MreB/Mbl protein//Cytochrome b/b6/petB//RNA polymerases N / 8 kDa subunit//SHS2 domain inserted in FTSA//NAD dependent epimerase/dehydratase family//Hydantoinase/oxoprolinase GO:0008207//GO:0000902//GO:0055114//GO:0005975//GO:0006388//GO:0022904//GO:0008152//GO:0008210//GO:0008209//GO:0006694//GO:0007304//GO:0007049//GO:0006351//GO:0006144//GO:0006206 C21-steroid hormone metabolic process//cell morphogenesis//oxidation-reduction process//carbohydrate metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain//metabolic process//estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//chorion-containing eggshell formation//cell cycle//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0005524//GO:0003854//GO:0016616//GO:0016491//GO:0016773//GO:0003676//GO:0046872//GO:0050662//GO:0005213//GO:0003899//GO:0016787//GO:0003972//GO:0003824//GO:0003677//GO:0005515 ATP binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//phosphotransferase activity, alcohol group as acceptor//nucleic acid binding//metal ion binding//coenzyme binding//structural constituent of chorion//DNA-directed RNA polymerase activity//hydrolase activity//RNA ligase (ATP) activity//catalytic activity//DNA binding//protein binding GO:0005730//GO:0042600//GO:0005576//GO:0016020 nucleolus//chorion//extracellular region//membrane KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.38435 BP_3 1491.51 14.20 5353 91083881 XP_967558.1 1326 6.1e-143 PREDICTED: D-3-phosphoglycerate dehydrogenase [Tribolium castaneum]>gi|270006715|gb|EFA03163.1| hypothetical protein TcasGA2_TC013082 [Tribolium castaneum] -- -- -- -- -- K00058 serA, PHGDH D-3-phosphoglycerate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00058 Q61753 887 2.0e-93 D-3-phosphoglycerate dehydrogenase OS=Mus musculus GN=Phgdh PE=1 SV=3 PF02826//PF03446//PF00389//PF07347 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) GO:0006098//GO:0008152//GO:0006744//GO:0006544//GO:0006564//GO:0042773//GO:0006120//GO:0006814//GO:0006566//GO:0019521//GO:0015992//GO:0055114 pentose-phosphate shunt//metabolic process//ubiquinone biosynthetic process//glycine metabolic process//L-serine biosynthetic process//ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//threonine metabolic process//D-gluconate metabolic process//proton transport//oxidation-reduction process GO:0051287//GO:0004617//GO:0016616//GO:0004616//GO:0008137 NAD binding//phosphoglycerate dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//NADH dehydrogenase (ubiquinone) activity GO:0005743 mitochondrial inner membrane KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily Cluster-8309.38437 BP_3 564.65 2.81 9984 642914147 XP_008201565.1 9361 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1238 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.1e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.38438 BP_3 526.80 7.56 3650 571529397 XP_006567771.1 1762 1.1e-193 PREDICTED: nucleolar protein 58-like [Apis mellifera] 242020751 XM_002430770.1 269 4.81711e-136 Pediculus humanus corporis Nucleolar protein NOP5, putative, mRNA K14565 NOP58 nucleolar protein 58 http://www.genome.jp/dbget-bin/www_bget?ko:K14565 Q9QZ86 1418 3.7e-155 Nucleolar protein 58 OS=Rattus norvegicus GN=Nop58 PE=1 SV=1 PF04858 TH1 protein GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2572 Ribosome biogenesis protein - Nop58p/Nop5p Cluster-8309.38441 BP_3 132.88 4.37 1757 642920190 XP_008192241.1 460 5.2e-43 PREDICTED: protein lin-52 homolog [Tribolium castaneum]>gi|270005293|gb|EFA01741.1| hypothetical protein TcasGA2_TC007337 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0AUQ6 254 1.7e-20 Protein lin-52 homolog OS=Danio rerio GN=lin52 PE=3 SV=1 PF03791//PF10044 KNOX2 domain//Retinal tissue protein GO:0007049//GO:0006351 cell cycle//transcription, DNA-templated GO:0003677 DNA binding GO:0070176//GO:0005634 DRM complex//nucleus -- -- Cluster-8309.38442 BP_3 28.89 0.37 4075 642920169 XP_008192230.1 3536 0.0e+00 PREDICTED: echinoderm microtubule-associated protein-like 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18595 EML1_2 echinoderm microtubule-associated protein-like 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18595 Q4V8C3 1931 1.3e-214 Echinoderm microtubule-associated protein-like 1 OS=Rattus norvegicus GN=Eml1 PE=2 SV=2 PF00930//PF00400 Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains Cluster-8309.38443 BP_3 223.13 2.79 4143 642918982 XP_008191684.1 4667 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.28995e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3159 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0206 P-type ATPase Cluster-8309.38445 BP_3 39.85 1.07 2085 91087441 XP_975685.1 230 2.9e-16 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27017 169 1.4e-10 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.38447 BP_3 71.39 1.32 2900 385845164 AFI81409.1 1440 2.0e-156 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 56 9.72342e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 586 8.7e-59 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF03099//PF03728//PF08127 Biotin/lipoate A/B protein ligase family//Viral DNA-binding protein, zinc binding domain//Peptidase family C1 propeptide GO:0050790//GO:0006508//GO:0006260//GO:0006464 regulation of catalytic activity//proteolysis//DNA replication//cellular protein modification process GO:0004197//GO:0003677//GO:0008270 cysteine-type endopeptidase activity//DNA binding//zinc ion binding -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.38448 BP_3 24.19 0.46 2822 385845164 AFI81409.1 647 1.7e-64 lipoate protein ligase [Phyllotreta striolata] -- -- -- -- -- K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 311 6.5e-27 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF08127//PF03099 Peptidase family C1 propeptide//Biotin/lipoate A/B protein ligase family GO:0050790//GO:0006464//GO:0006508 regulation of catalytic activity//cellular protein modification process//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.38449 BP_3 357.54 4.94 3779 270010219 EFA06667.1 2551 3.8e-285 hypothetical protein TcasGA2_TC009594 [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 951 5.4e-101 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF07646//PF00651//PF01344 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.3845 BP_3 4.98 0.58 708 91078890 XP_973183.1 531 1.2e-51 PREDICTED: GTP-binding protein Rhes [Tribolium castaneum]>gi|270004145|gb|EFA00593.1| hypothetical protein TcasGA2_TC003464 [Tribolium castaneum] -- -- -- -- -- K07843 RASD1 RAS, dexamethasone-induced Ras-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07843 O35626 342 4.2e-31 Dexamethasone-induced Ras-related protein 1 OS=Mus musculus GN=Rasd1 PE=1 SV=1 PF08477//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.38452 BP_3 55.16 0.47 5997 642927920 XP_008195448.1 2122 3.4e-235 PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927922|ref|XP_008195449.1| PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927924|ref|XP_974516.2| PREDICTED: dystroglycan [Tribolium castaneum] 642927923 XM_969423.3 68 4.31919e-24 PREDICTED: Tribolium castaneum dystroglycan (LOC663372), transcript variant X3, mRNA K06265 DAG1 dystroglycan 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06265 Q9TSZ6 506 3.4e-49 Dystroglycan OS=Canis familiaris GN=DAG1 PE=3 SV=1 PF05454//PF03176 Dystroglycan (Dystrophin-associated glycoprotein 1)//MMPL family GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016020//GO:0016010 membrane//dystrophin-associated glycoprotein complex KOG3781 Dystroglycan Cluster-8309.38453 BP_3 4152.69 39.77 5325 642927920 XP_008195448.1 2122 3.0e-235 PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927922|ref|XP_008195449.1| PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927924|ref|XP_974516.2| PREDICTED: dystroglycan [Tribolium castaneum] 642927923 XM_969423.3 68 3.83227e-24 PREDICTED: Tribolium castaneum dystroglycan (LOC663372), transcript variant X3, mRNA K06265 DAG1 dystroglycan 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06265 Q9TSZ6 506 3.0e-49 Dystroglycan OS=Canis familiaris GN=DAG1 PE=3 SV=1 PF05454//PF03176 Dystroglycan (Dystrophin-associated glycoprotein 1)//MMPL family GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016020//GO:0016010 membrane//dystrophin-associated glycoprotein complex KOG3781 Dystroglycan Cluster-8309.38456 BP_3 439.06 14.30 1772 332376226 AEE63253.1 1767 1.5e-194 unknown [Dendroctonus ponderosae] 282158080 NM_001170613.1 385 0 Tribolium castaneum arrestin 2 (Arr2), mRNA K13805 ARR2 arrestin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13805 P32122 1583 1.3e-174 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.38458 BP_3 175.88 2.19 4160 642920920 XP_008192616.1 930 3.9e-97 PREDICTED: uncharacterized protein LOC103312812 [Tribolium castaneum]>gi|270005158|gb|EFA01606.1| hypothetical protein TcasGA2_TC007172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434//PF00520//PF10798//PF02706//PF15957 TMEM9//Ion transport protein//Biofilm development protein YmgB/AriR//Chain length determinant protein//Commissureless GO:0006811//GO:0042710//GO:0071229//GO:0055085//GO:0009103//GO:0007411 ion transport//biofilm formation//cellular response to acid chemical//transmembrane transport//lipopolysaccharide biosynthetic process//axon guidance GO:0005216 ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.38460 BP_3 1089.67 6.44 8441 270001798 EEZ98245.1 3839 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 470 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q14554 162 3.7e-09 Protein disulfide-isomerase A5 OS=Homo sapiens GN=PDIA5 PE=1 SV=1 PF08534//PF02382//PF00578//PF02020//PF02724//PF00085//PF07689//PF06524//PF01791 Redoxin//RTX N-terminal domain//AhpC/TSA family//eIF4-gamma/eIF5/eIF2-epsilon//CDC45-like protein//Thioredoxin//KaiB domain//NOA36 protein//DeoC/LacD family aldolase GO:0009405//GO:0048511//GO:0006270//GO:0055114//GO:0045454 pathogenesis//rhythmic process//DNA replication initiation//oxidation-reduction process//cell redox homeostasis GO:0005515//GO:0016491//GO:0005509//GO:0008270//GO:0016209//GO:0016829 protein binding//oxidoreductase activity//calcium ion binding//zinc ion binding//antioxidant activity//lyase activity GO:0005634//GO:0005576 nucleus//extracellular region KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.38462 BP_3 300.30 2.67 5707 642914502 XP_008201702.1 1282 8.2e-138 PREDICTED: RUN and FYVE domain-containing protein 2 isoform X2 [Tribolium castaneum] 831282704 XM_012817043.1 41 4.1972e-09 PREDICTED: Clupea harengus RUN and FYVE domain containing 2 (rufy2), mRNA -- -- -- -- Q5R5R4 715 1.9e-73 RUN and FYVE domain-containing protein 2 OS=Pongo abelii GN=RUFY2 PE=2 SV=1 PF05191//PF02841//PF07926//PF01363//PF10473//PF00038//PF08657//PF08702//PF14634//PF06005//PF01155//PF03462//PF08172 Adenylate kinase, active site lid//Guanylate-binding protein, C-terminal domain//TPR/MLP1/MLP2-like protein//FYVE zinc finger//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Intermediate filament protein//DASH complex subunit Spc34//Fibrinogen alpha/beta chain family//zinc-RING finger domain//Protein of unknown function (DUF904)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//PCRF domain//CASP C terminal GO:0006891//GO:0030168//GO:0006415//GO:0008608//GO:0006606//GO:0006449//GO:0006144//GO:0043093//GO:0000917//GO:0007165//GO:0006464//GO:0046034//GO:0051258 intra-Golgi vesicle-mediated transport//platelet activation//translational termination//attachment of spindle microtubules to kinetochore//protein import into nucleus//regulation of translational termination//purine nucleobase metabolic process//FtsZ-dependent cytokinesis//barrier septum assembly//signal transduction//cellular protein modification process//ATP metabolic process//protein polymerization GO:0030674//GO:0046872//GO:0045502//GO:0003924//GO:0008134//GO:0005102//GO:0005515//GO:0016149//GO:0016151//GO:0005525//GO:0042803//GO:0005198//GO:0008270//GO:0004017 protein binding, bridging//metal ion binding//dynein binding//GTPase activity//transcription factor binding//receptor binding//protein binding//translation release factor activity, codon specific//nickel cation binding//GTP binding//protein homodimerization activity//structural molecule activity//zinc ion binding//adenylate kinase activity GO:0030286//GO:0005667//GO:0030173//GO:0005882//GO:0005577//GO:0018444//GO:0042729//GO:0005840//GO:0005737//GO:0005876 dynein complex//transcription factor complex//integral component of Golgi membrane//intermediate filament//fibrinogen complex//translation release factor complex//DASH complex//ribosome//cytoplasm//spindle microtubule -- -- Cluster-8309.38468 BP_3 39.25 0.67 3116 270007722 EFA04170.1 2227 1.2e-247 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 775 1.1e-80 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.38469 BP_3 384.31 3.56 5497 642930795 XP_008196094.1 4759 0.0e+00 PREDICTED: tight junction protein ZO-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05701 TJP1, ZO1 tight junction protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05701 Q9UDY2 891 7.1e-94 Tight junction protein ZO-2 OS=Homo sapiens GN=TJP2 PE=1 SV=2 PF00018//PF00595//PF13180 SH3 domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3580 Tight junction proteins Cluster-8309.3847 BP_3 20.00 0.71 1659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38470 BP_3 225.92 3.10 3800 91086631 XP_966390.1 1013 8.5e-107 PREDICTED: abhydrolase domain-containing protein 2 [Tribolium castaneum]>gi|270010379|gb|EFA06827.1| hypothetical protein TcasGA2_TC009769 [Tribolium castaneum] -- -- -- -- -- K13697 ABHD2 abhydrolase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13697 Q24093 870 1.3e-91 Abhydrolase domain-containing protein 2 OS=Drosophila melanogaster GN=Hydr2 PE=2 SV=2 PF01083//PF01738//PF02230//PF00326//PF01764 Cutinase//Dienelactone hydrolase family//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3) GO:0006629//GO:0006508//GO:0008152 lipid metabolic process//proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- KOG1838 Alpha/beta hydrolase Cluster-8309.38471 BP_3 18.03 0.45 2213 91083699 XP_969478.1 1065 4.6e-113 PREDICTED: periostin [Tribolium castaneum]>gi|270007879|gb|EFA04327.1| hypothetical protein TcasGA2_TC014621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38472 BP_3 976.00 16.48 3146 642916369 XP_008190992.1 1606 1.2e-175 PREDICTED: TOM1-like protein 2 isoform X1 [Tribolium castaneum]>gi|270004201|gb|EFA00649.1| hypothetical protein TcasGA2_TC003525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRX1 845 8.7e-89 TOM1-like protein 2 OS=Mus musculus GN=Tom1l2 PE=2 SV=1 PF03127//PF00790 GAT domain//VHS domain GO:0006886 intracellular protein transport -- -- GO:0005622 intracellular KOG1087 Cytosolic sorting protein GGA2/TOM1 Cluster-8309.38474 BP_3 1317.00 84.95 1039 91083699 XP_969478.1 949 6.1e-100 PREDICTED: periostin [Tribolium castaneum]>gi|270007879|gb|EFA04327.1| hypothetical protein TcasGA2_TC014621 [Tribolium castaneum] 642924333 XM_964385.3 145 1.14408e-67 PREDICTED: Tribolium castaneum periostin (LOC657966), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38476 BP_3 145.00 5.37 1592 91087181 XP_975417.1 912 1.8e-95 PREDICTED: mediator of RNA polymerase II transcription subunit 6 [Tribolium castaneum] -- -- -- -- -- K15128 MED6 mediator of RNA polymerase II transcription subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K15128 Q7Q107 740 6.6e-77 Mediator of RNA polymerase II transcription subunit 6 OS=Anopheles gambiae GN=MED6 PE=3 SV=3 PF04934 MED6 mediator sub complex component GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3169 RNA polymerase II transcriptional regulation mediator Cluster-8309.38477 BP_3 4.84 0.37 923 91093667 XP_975936.1 635 1.4e-63 PREDICTED: 60S acidic ribosomal protein P0 [Tribolium castaneum]>gi|270008063|gb|EFA04511.1| hypothetical protein TcasGA2_TC016306 [Tribolium castaneum] 39651866 AJ534439.1 161 1.29075e-76 Timarcha balearica mRNA for 60S acidic ribosomal protein P0 (rpP0 gene) K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 Q9U3U0 588 1.6e-59 60S acidic ribosomal protein P0 OS=Ceratitis capitata GN=RpLP0 PE=3 SV=1 PF00466//PF08106 Ribosomal protein L10//Formaecin family GO:0006414//GO:0042742//GO:0042254//GO:0042381 translational elongation//defense response to bacterium//ribosome biogenesis//hemolymph coagulation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0815 60S acidic ribosomal protein P0 Cluster-8309.38478 BP_3 1824.23 33.05 2952 270014159 EFA10607.1 563 1.0e-54 hypothetical protein TcasGA2_TC012868 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 426 3.2e-40 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00102//PF08777//PF04179//PF16367//PF00076//PF01416//PF01529//PF00782//PF02868 Protein-tyrosine phosphatase//RNA binding motif//Initiator tRNA phosphoribosyl transferase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA pseudouridine synthase//DHHC palmitoyltransferase//Dual specificity phosphatase, catalytic domain//Thermolysin metallopeptidase, alpha-helical domain GO:0006570//GO:0006470//GO:0019988//GO:0001522//GO:0009451 tyrosine metabolic process//protein dephosphorylation//charged-tRNA amino acid modification//pseudouridine synthesis//RNA modification GO:0004725//GO:0008138//GO:0043399//GO:0004222//GO:0003723//GO:0009982//GO:0003676//GO:0008270 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity//metalloendopeptidase activity//RNA binding//pseudouridine synthase activity//nucleic acid binding//zinc ion binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.3848 BP_3 18.35 0.51 2041 642913680 XP_008201115.1 606 7.1e-60 PREDICTED: protein amalgam-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38480 BP_3 577.15 7.05 4236 642916400 XP_008191007.1 1394 6.3e-151 PREDICTED: protein cueball [Tribolium castaneum] 827558792 XM_004931531.2 37 5.2016e-07 PREDICTED: Bombyx mori protein cueball (LOC101741085), mRNA K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 B3M8G0 742 1.0e-76 Protein cueball OS=Drosophila ananassae GN=cue PE=3 SV=1 PF05393//PF00008 Human adenovirus early E3A glycoprotein//EGF-like domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.38481 BP_3 342.24 23.46 995 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00724 NADH:flavin oxidoreductase / NADH oxidase family GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- -- -- Cluster-8309.38482 BP_3 73.66 1.19 3278 546686533 ERL95731.1 499 2.9e-47 hypothetical protein D910_00173, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38483 BP_3 258.97 2.71 4898 189235133 XP_966882.2 3260 0.0e+00 PREDICTED: EH domain-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270003802|gb|EFA00250.1| hypothetical protein TcasGA2_TC003079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDI1 547 4.9e-54 EH domain-binding protein 1 OS=Homo sapiens GN=EHBP1 PE=1 SV=3 PF00307//PF05366 Calponin homology (CH) domain//Sarcolipin -- -- GO:0030234//GO:0005515 enzyme regulator activity//protein binding GO:0016020 membrane -- -- Cluster-8309.38485 BP_3 1183.68 10.60 5675 189234402 XP_974971.2 1311 3.5e-141 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] 356640774 JN597285.1 870 0 Anastrepha suspensa transformer female-specific transcript variant and truncated transformer male-specific transcript (tra) gene, complete cds, alternatively spliced -- -- -- -- Q5VY43 328 1.4e-28 Platelet endothelial aggregation receptor 1 OS=Homo sapiens GN=PEAR1 PE=1 SV=1 PF01414//PF04790//PF00008//PF10288//PF05699 Delta serrate ligand//Sarcoglycan complex subunit protein//EGF-like domain//Cytoplasmic tRNA 2-thiolation protein 2//hAT family C-terminal dimerisation region GO:0002098//GO:0034227//GO:0007154 tRNA wobble uridine modification//tRNA thio-modification//cell communication GO:0000049//GO:0005515//GO:0046983 tRNA binding//protein binding//protein dimerization activity GO:0016021//GO:0016012//GO:0016020 integral component of membrane//sarcoglycan complex//membrane KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.38486 BP_3 1641.44 27.37 3182 91076670 XP_971562.1 2416 1.5e-269 PREDICTED: ATP-binding cassette sub-family F member 1 [Tribolium castaneum]>gi|270002367|gb|EEZ98814.1| hypothetical protein TcasGA2_TC004420 [Tribolium castaneum] 195480796 XM_002101360.1 253 3.28782e-127 Drosophila yakuba GE15656 (Dyak\GE15656), partial mRNA K06184 ABCF1 ATP-binding cassette, subfamily F, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06184 Q767L0 1764 2.4e-195 ATP-binding cassette sub-family F member 1 OS=Sus scrofa GN=ABCF1 PE=3 SV=1 PF00910//PF01637//PF03266//PF03193//PF00005//PF00448//PF00931//PF06003//PF02367//PF01008//PF07213//PF00004//PF13304//PF01926//PF07728//PF08477//PF00488 RNA helicase//Archaeal ATPase//NTPase//Protein of unknown function, DUF258//ABC transporter//SRP54-type protein, GTPase domain//NB-ARC domain//Survival motor neuron protein (SMN)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Initiation factor 2 subunit family//DAP10 membrane protein//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//MutS domain V GO:0007264//GO:0002949//GO:0006298//GO:0014068//GO:0006397//GO:0050776//GO:0006200//GO:0044237//GO:0007165//GO:0006614 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//mismatch repair//positive regulation of phosphatidylinositol 3-kinase signaling//mRNA processing//regulation of immune response//obsolete ATP catabolic process//cellular metabolic process//signal transduction//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0005525//GO:0043531//GO:0003723//GO:0030983//GO:0005102//GO:0016887//GO:0043548//GO:0003924//GO:0005524//GO:0098519 RNA helicase activity//GTP binding//ADP binding//RNA binding//mismatched DNA binding//receptor binding//ATPase activity//phosphatidylinositol 3-kinase binding//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides GO:0016020//GO:0005634//GO:0005737 membrane//nucleus//cytoplasm KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.38489 BP_3 14.18 0.76 1186 268306372 ACY95307.1 626 2.0e-62 ribosomal protein P0 [Manduca sexta] 18253040 AY072284.1 167 7.71788e-80 Spodoptera frugiperda 60S acidic ribosomal protein P0 mRNA, complete cds K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 P19889 584 6.1e-59 60S acidic ribosomal protein P0 OS=Drosophila melanogaster GN=RpLP0 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0815 60S acidic ribosomal protein P0 Cluster-8309.38490 BP_3 57.30 1.33 2365 91078958 XP_974220.1 498 2.8e-47 PREDICTED: cathepsin B [Tribolium castaneum]>gi|642916227|ref|XP_008190938.1| PREDICTED: cathepsin B [Tribolium castaneum]>gi|270004841|gb|EFA01289.1| cathepsin B precursor [Tribolium castaneum] 642916228 XM_969127.2 108 9.81065e-47 PREDICTED: Tribolium castaneum cathepsin B precursor (LOC663066), transcript variant X2, mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P43233 394 1.3e-36 Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1 PF08127//PF00112 Peptidase family C1 propeptide//Papain family cysteine protease GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.38491 BP_3 368.27 7.88 2545 478260090 ENN79875.1 1710 8.6e-188 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 3.99411e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 1414 7.4e-155 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006012//GO:0006098//GO:0006096//GO:0006000//GO:0006013//GO:0006094 galactose metabolic process//pentose-phosphate shunt//glycolytic process//fructose metabolic process//mannose metabolic process//gluconeogenesis GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.38494 BP_3 2991.26 18.56 8060 157106769 XP_001649474.1 419 1.4e-37 AAEL014742-PA, partial [Aedes aegypti]>gi|108868779|gb|EAT33004.1| AAEL014742-PA, partial [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q28F51 957 2.3e-101 TAR DNA-binding protein 43 OS=Xenopus tropicalis GN=tardbp PE=2 SV=1 PF15750//PF00096//PF07776//PF13606//PF16367//PF00076//PF03104//PF13465//PF00023//PF16622//PF02892//PF13912 Ubiquitin-binding zinc-finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Ankyrin repeat//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//DNA polymerase family B, exonuclease domain//Zinc-finger double domain//Ankyrin repeat//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0003676//GO:0008408//GO:0008270//GO:0005515//GO:0003677//GO:0043130 metal ion binding//nucleic acid binding//3'-5' exonuclease activity//zinc ion binding//protein binding//DNA binding//ubiquitin binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.38495 BP_3 35.00 0.93 2115 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38496 BP_3 268.91 2.92 4731 478262128 ENN81013.1 3533 0.0e+00 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 529 5.8e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38497 BP_3 716.55 35.67 1260 332376436 AEE63358.1 857 3.4e-89 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 526 3.4e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38498 BP_3 1668.83 19.33 4454 478262128 ENN81013.1 3533 0.0e+00 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 529 5.4e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 PF00498 FHA domain -- -- GO:0005515 protein binding -- -- KOG0245 Kinesin-like protein Cluster-8309.38500 BP_3 41.44 0.85 2642 546683392 ERL93211.1 1990 3.0e-220 hypothetical protein D910_10507, partial [Dendroctonus ponderosae] 642936324 XM_008200175.1 104 1.83684e-44 PREDICTED: Tribolium castaneum integrin beta-PS (LOC657674), transcript variant X2, mRNA K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 1525 1.0e-167 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.38501 BP_3 179.10 1.59 5705 642931136 XP_967600.2 3863 0.0e+00 PREDICTED: DNA-directed RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270012086|gb|EFA08534.1| hypothetical protein TcasGA2_TC006188 [Tribolium castaneum] -- -- -- -- -- K10908 POLRMT, RPO41 DNA-directed RNA polymerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K10908 Q8BKF1 1977 8.7e-220 DNA-directed RNA polymerase, mitochondrial OS=Mus musculus GN=Polrmt PE=2 SV=1 PF00940//PF03840 DNA-dependent RNA polymerase//Preprotein translocase SecG subunit GO:0006206//GO:0015031//GO:0006351//GO:0006144//GO:0009306 pyrimidine nucleobase metabolic process//protein transport//transcription, DNA-templated//purine nucleobase metabolic process//protein secretion GO:0015450//GO:0003899//GO:0003677//GO:0016740 P-P-bond-hydrolysis-driven protein transmembrane transporter activity//DNA-directed RNA polymerase activity//DNA binding//transferase activity GO:0005730//GO:0009941//GO:0016021 nucleolus//chloroplast envelope//integral component of membrane KOG1038 Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation Cluster-8309.38503 BP_3 12.57 0.50 1492 546672637 ERL84433.1 726 6.3e-74 hypothetical protein D910_01865, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6UXY8 346 3.0e-31 Transmembrane channel-like protein 5 OS=Homo sapiens GN=TMC5 PE=2 SV=3 PF06305//PF07810 Protein of unknown function (DUF1049)//TMC domain -- -- -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.38504 BP_3 592.00 24.98 1434 478257422 ENN77578.1 556 3.1e-54 hypothetical protein YQE_05874, partial [Dendroctonus ponderosae]>gi|546685701|gb|ERL95162.1| hypothetical protein D910_12431 [Dendroctonus ponderosae] -- -- -- -- -- K15306 RANBP1 Ran-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15306 Q3T0M7 405 4.2e-38 Ran-specific GTPase-activating protein OS=Bos taurus GN=RANBP1 PE=2 SV=1 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.38505 BP_3 376.98 4.88 4015 642926470 XP_008191971.1 1644 6.1e-180 PREDICTED: flotillin-2 isoform X1 [Tribolium castaneum] 645037638 XM_008207769.1 344 1.07721e-177 PREDICTED: Nasonia vitripennis flotillin-2 (LOC103316081), mRNA K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61492 1513 3.9e-166 Flotillin-2 OS=Drosophila melanogaster GN=Flo-2 PE=2 SV=3 PF12052 Voltage gated calcium channel subunit beta domain 4Aa N terminal GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005245 voltage-gated calcium channel activity GO:0005891 voltage-gated calcium channel complex -- -- Cluster-8309.38506 BP_3 509.65 6.36 4157 91076824 XP_967870.1 1208 2.3e-129 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 729 3.3e-75 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.38507 BP_3 536.44 5.85 4708 642911698 XP_008200706.1 1667 1.5e-182 PREDICTED: uncharacterized protein CG10915 isoform X1 [Tribolium castaneum] 642911699 XM_008202485.1 290 1.31967e-147 PREDICTED: Tribolium castaneum uncharacterized protein CG10915 (LOC658989), transcript variant X2, mRNA -- -- -- -- Q8SX68 804 7.4e-84 Uncharacterized protein CG10915 OS=Drosophila melanogaster GN=CG10915 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1103 Predicted coiled-coil protein Cluster-8309.3851 BP_3 4.00 2.43 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38510 BP_3 17.00 7.16 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38513 BP_3 51.32 0.79 3418 727098932 AIY54299.1 990 3.5e-104 glyceraldehyde 3-phosphate dehydrogenase [Colaphellus bowringi] 329402518 HQ340216.1 177 6.25879e-85 Abraxas grossulariatus voucher TUZ600965 glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene, partial cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q4U3L0 911 2.1e-96 Glyceraldehyde-3-phosphate dehydrogenase OS=Glossina morsitans morsitans GN=Gapdh PE=2 SV=1 PF02800//PF00107//PF02826//PF00044 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Zinc-binding dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016620//GO:0051287 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.38514 BP_3 1291.60 7.20 8943 642930696 XP_008199991.1 1575 1.4e-171 PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930698|ref|XP_008199992.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930700|ref|XP_008199993.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|270012671|gb|EFA09119.1| hypothetical protein TcasGA2_TC015979 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11883 1236 1.1e-133 Aldehyde dehydrogenase, dimeric NADP-preferring OS=Rattus norvegicus GN=Aldh3a1 PE=1 SV=3 PF00171//PF07690//PF02558//PF08656//PF01370//PF00106 Aldehyde dehydrogenase family//Major Facilitator Superfamily//Ketopantoate reductase PanE/ApbA//DASH complex subunit Dad3//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0015940//GO:0055085//GO:0006096//GO:0006570//GO:0006558//GO:0006094//GO:0008608//GO:0055114//GO:0008152//GO:0006081//GO:0006547 pantothenate biosynthetic process//transmembrane transport//glycolytic process//tyrosine metabolic process//L-phenylalanine metabolic process//gluconeogenesis//attachment of spindle microtubules to kinetochore//oxidation-reduction process//metabolic process//cellular aldehyde metabolic process//histidine metabolic process GO:0050662//GO:0003824//GO:0016491//GO:0008677//GO:0004030 coenzyme binding//catalytic activity//oxidoreductase activity//2-dehydropantoate 2-reductase activity//aldehyde dehydrogenase [NAD(P)+] activity GO:0016021//GO:0042729//GO:0072686 integral component of membrane//DASH complex//mitotic spindle KOG2456 Aldehyde dehydrogenase Cluster-8309.38515 BP_3 3577.65 29.04 6230 91086811 XP_973640.1 2901 0.0e+00 PREDICTED: tetratricopeptide repeat protein 30A [Tribolium castaneum]>gi|270009704|gb|EFA06152.1| hypothetical protein TcasGA2_TC008997 [Tribolium castaneum] 665813619 XM_008557152.1 150 1.17086e-69 PREDICTED: Microplitis demolitor tetratricopeptide repeat protein 30A (LOC103576769), mRNA -- -- -- -- A4IHR1 2294 1.6e-256 Tetratricopeptide repeat protein 30A OS=Xenopus tropicalis GN=ttc30a PE=2 SV=1 PF13181//PF13174//PF00031//PF00112//PF00515//PF13414//PF00333//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Cystatin domain//Papain family cysteine protease//Tetratricopeptide repeat//TPR repeat//Ribosomal protein S5, N-terminal domain//Tetratricopeptide repeat GO:0006412//GO:0006508//GO:0042254 translation//proteolysis//ribosome biogenesis GO:0003723//GO:0004869//GO:0005515//GO:0003735//GO:0008234 RNA binding//cysteine-type endopeptidase inhibitor activity//protein binding//structural constituent of ribosome//cysteine-type peptidase activity GO:0005840 ribosome KOG1542 Cysteine proteinase Cathepsin F Cluster-8309.38516 BP_3 1376.95 5.06 13419 478257788 ENN77931.1 3951 0.0e+00 hypothetical protein YQE_05608, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 435 1.3e-40 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF10034//PF13606//PF00023//PF10510 Q-cell neuroblast polarisation//Ankyrin repeat//Ankyrin repeat//Phosphatidylinositol-glycan biosynthesis class S protein GO:0016255 attachment of GPI anchor to protein GO:0005515 protein binding GO:0042765//GO:0016021 GPI-anchor transamidase complex//integral component of membrane -- -- Cluster-8309.38517 BP_3 2138.00 225.36 749 478253250 ENN73621.1 690 4.7e-70 hypothetical protein YQE_09868, partial [Dendroctonus ponderosae]>gi|546676347|gb|ERL87374.1| hypothetical protein D910_04769 [Dendroctonus ponderosae] 667677333 AE014297.3 68 5.18396e-25 Drosophila melanogaster chromosome 3R K02138 ATPeF0D, ATP5H, ATP7 F-type H+-transporting ATPase subunit d http://www.genome.jp/dbget-bin/www_bget?ko:K02138 Q24251 589 1.0e-59 ATP synthase subunit d, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-d PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3366 Mitochondrial F1F0-ATP synthase, subunit d/ATP7 Cluster-8309.38518 BP_3 24614.74 220.80 5665 393010342 AFN02498.1 2025 5.7e-224 heat shock protein 90 [Tenebrio molitor] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 9.8e-216 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF04857//PF11605//PF10510//PF00183 CAF1 family ribonuclease//Vacuolar protein sorting protein 36 Vps36//Phosphatidylinositol-glycan biosynthesis class S protein//Hsp90 protein GO:0006950//GO:0006457//GO:0016255 response to stress//protein folding//attachment of GPI anchor to protein GO:0005524//GO:0043130//GO:0051082//GO:0032266 ATP binding//ubiquitin binding//unfolded protein binding//phosphatidylinositol-3-phosphate binding GO:0005634//GO:0042765 nucleus//GPI-anchor transamidase complex KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.38519 BP_3 94.99 0.35 13491 478257788 ENN77931.1 3951 0.0e+00 hypothetical protein YQE_05608, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 435 1.3e-40 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF10510//PF00023//PF13606//PF10034 Phosphatidylinositol-glycan biosynthesis class S protein//Ankyrin repeat//Ankyrin repeat//Q-cell neuroblast polarisation GO:0016255 attachment of GPI anchor to protein GO:0005515 protein binding GO:0016021//GO:0042765 integral component of membrane//GPI-anchor transamidase complex -- -- Cluster-8309.3852 BP_3 5.00 0.55 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38520 BP_3 2042.73 17.58 5892 769847492 XP_011635083.1 2338 3.0e-260 PREDICTED: EH domain-containing protein 3 isoform X1 [Pogonomyrmex barbatus] 462311205 APGK01047050.1 382 0 Dendroctonus ponderosae Seq01047060, whole genome shotgun sequence K12483 EHD1 EH domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12483 Q5RBP4 1964 2.9e-218 EH domain-containing protein 1 OS=Pongo abelii GN=EHD1 PE=2 SV=1 PF02421//PF12763//PF01926//PF13833//PF13405//PF08477//PF02392//PF13499//PF13202//PF04548//PF04670//PF02367//PF00782//PF03193//PF00036 Ferrous iron transport protein B//Cytoskeletal-regulatory complex EF hand//50S ribosome-binding GTPase//EF-hand domain pair//EF-hand domain//Ras of Complex, Roc, domain of DAPkinase//Ycf4//EF-hand domain pair//EF hand//AIG1 family//Gtr1/RagA G protein conserved region//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Dual specificity phosphatase, catalytic domain//Protein of unknown function, DUF258//EF hand GO:0002949//GO:0015684//GO:0007264//GO:0015979//GO:0006470 tRNA threonylcarbamoyladenosine modification//ferrous iron transport//small GTPase mediated signal transduction//photosynthesis//protein dephosphorylation GO:0005509//GO:0005525//GO:0015093//GO:0003924//GO:0008138//GO:0005515 calcium ion binding//GTP binding//ferrous iron transmembrane transporter activity//GTPase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding GO:0009579//GO:0016021//GO:0009522 thylakoid//integral component of membrane//photosystem I -- -- Cluster-8309.38523 BP_3 1274.81 22.95 2969 478257812 ENN77955.1 419 5.0e-38 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0001522//GO:0042254 cellular protein modification process//pseudouridine synthesis//ribosome biogenesis GO:0030515//GO:0016151 snoRNA binding//nickel cation binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.38526 BP_3 777.83 20.19 2149 73921486 AAZ94273.1 2434 8.1e-272 cytochrome P450 [Leptinotarsa decemlineata] 73921485 DQ117464.1 404 0 Leptinotarsa decemlineata cytochrome P450 (CYP4G29) mRNA, complete cds K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 Q9VYY4 1879 7.5e-209 Cytochrome P450 4g15 OS=Drosophila melanogaster GN=Cyp4g15 PE=2 SV=1 PF00762//PF00067 Ferrochelatase//Cytochrome P450 GO:0015994//GO:0006783//GO:0055114 chlorophyll metabolic process//heme biosynthetic process//oxidation-reduction process GO:0020037//GO:0005506//GO:0016705//GO:0004325 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ferrochelatase activity -- -- -- -- Cluster-8309.38528 BP_3 4604.08 37.38 6228 91087897 XP_970459.1 859 1.0e-88 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270012016|gb|EFA08464.1| hypothetical protein TcasGA2_TC006113 [Tribolium castaneum] 642930872 XM_965366.2 96 1.22124e-39 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 1.4e-16 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF05495 CHY zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.38529 BP_3 4391.80 73.78 3161 642927459 XP_968905.2 858 6.6e-89 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q9EQZ5 563 4.4e-56 Prostaglandin reductase 1 OS=Cavia porcellus GN=Ptgr1 PE=1 SV=1 PF02879//PF00107 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Zinc-binding dehydrogenase GO:0005975//GO:0055114 carbohydrate metabolic process//oxidation-reduction process -- -- -- -- -- -- Cluster-8309.3853 BP_3 3.00 0.45 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38530 BP_3 9.00 0.77 852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38531 BP_3 27.58 0.55 2717 332376210 AEE63245.1 1230 4.2e-132 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XJP1 653 1.4e-66 Protein TSSC1 OS=Danio rerio GN=tssc1 PE=2 SV=1 PF01215//PF03121//PF00400 Cytochrome c oxidase subunit Vb//Herpesviridae UL52/UL70 DNA primase//WD domain, G-beta repeat GO:0006269//GO:0006260//GO:0015992//GO:0006123//GO:0006351 DNA replication, synthesis of RNA primer//DNA replication//proton transport//mitochondrial electron transport, cytochrome c to oxygen//transcription, DNA-templated GO:0004129//GO:0003896//GO:0005515 cytochrome-c oxidase activity//DNA primase activity//protein binding GO:0005740//GO:0005730//GO:0005657//GO:0045277 mitochondrial envelope//nucleolus//replication fork//respiratory chain complex IV KOG1007 WD repeat protein TSSC1, WD repeat superfamily Cluster-8309.38532 BP_3 733.09 7.91 4759 270008035 EFA04483.1 1785 3.2e-196 hypothetical protein TcasGA2_TC014788 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q14155 928 3.1e-98 Rho guanine nucleotide exchange factor 7 OS=Homo sapiens GN=ARHGEF7 PE=1 SV=2 PF10280//PF00018//PF14604//PF00621 Mediator complex protein//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023//GO:0006357 regulation of GTPase activity//regulation of Rho protein signal transduction//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0005515//GO:0005089 RNA polymerase II transcription cofactor activity//protein binding//Rho guanyl-nucleotide exchange factor activity GO:0016592 mediator complex KOG2070 Guanine nucleotide exchange factor Cluster-8309.38535 BP_3 1218.00 33.95 2021 270004992 EFA01440.1 2223 2.2e-247 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] 242022531 XM_002431649.1 134 2.94443e-61 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- Q9I7U4 1530 2.1e-168 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38536 BP_3 56.53 3.05 1186 642912101 XP_008200805.1 1567 1.5e-171 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [Tribolium castaneum] 665820405 XM_008560879.1 303 1.92981e-155 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 1193 1.5e-129 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF04111//PF00769//PF01496 Autophagy protein Apg6//Ezrin/radixin/moesin family//V-type ATPase 116kDa subunit family GO:0006914//GO:0015991//GO:0015992 autophagy//ATP hydrolysis coupled proton transport//proton transport GO:0008092//GO:0015078 cytoskeletal protein binding//hydrogen ion transmembrane transporter activity GO:0019898//GO:0033179//GO:0005737 extrinsic component of membrane//proton-transporting V-type ATPase, V0 domain//cytoplasm KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.38537 BP_3 55.34 0.50 5609 642926232 XP_008194839.1 846 2.9e-87 PREDICTED: transcriptional activator protein Pur-alpha isoform X2 [Tribolium castaneum] 642926231 XM_008196617.1 95 3.95325e-39 PREDICTED: Tribolium castaneum transcriptional activator protein Pur-alpha (LOC662482), transcript variant X2, mRNA -- -- -- -- Q00577 372 1.1e-33 Transcriptional activator protein Pur-alpha OS=Homo sapiens GN=PURA PE=1 SV=2 PF09284 Rhamnogalacturonan lyase B, N-terminal GO:0005975 carbohydrate metabolic process GO:0030246//GO:0016837 carbohydrate binding//carbon-oxygen lyase activity, acting on polysaccharides -- -- KOG3074 Transcriptional regulator of the PUR family, single-stranded-DNA-binding Cluster-8309.38538 BP_3 64.97 0.40 8064 533200262 XP_005412710.1 597 3.1e-58 PREDICTED: zinc finger protein 347-like isoform X2 [Chinchilla lanigera] 642926231 XM_008196617.1 95 5.69223e-39 PREDICTED: Tribolium castaneum transcriptional activator protein Pur-alpha (LOC662482), transcript variant X2, mRNA -- -- -- -- A6NK75 565 6.6e-56 Zinc finger protein 98 OS=Homo sapiens GN=ZNF98 PE=2 SV=4 PF00096//PF13465//PF16622//PF03248//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//Rer1 family//C2H2-type zinc finger -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.38539 BP_3 1054.51 5.75 9135 642933138 XP_008197272.1 7873 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 13 isoform X1 [Tribolium castaneum] 642933139 XM_008199051.1 239 5.76124e-119 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 3.4e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF02671//PF06333//PF10501 Paired amphipathic helix repeat//Mediator complex subunit 13 C-terminal//Ribosomal subunit 39S GO:0006355//GO:0006357 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005739 mediator complex//mitochondrion KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.38542 BP_3 197.78 1.99 5078 91095163 XP_968103.1 3134 0.0e+00 PREDICTED: phosphorylated CTD-interacting factor 1 [Tribolium castaneum]>gi|270015787|gb|EFA12235.1| hypothetical protein TcasGA2_TC004110 [Tribolium castaneum] -- -- -- -- -- K17584 PCIF1 phosphorylated CTD-interacting factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17584 Q9H4Z3 1532 3.1e-168 Phosphorylated CTD-interacting factor 1 OS=Homo sapiens GN=PCIF1 PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38544 BP_3 2945.18 13.56 10761 642916043 XP_008190869.1 3028 0.0e+00 PREDICTED: ras-GEF domain-containing family member 1B-like isoform X1 [Tribolium castaneum] 808119259 XM_012307759.1 168 1.99807e-79 PREDICTED: Bombus terrestris ras-GEF domain-containing family member 1B-like (LOC100645439), transcript variant X2, mRNA -- -- -- -- Q6DHR3 1300 5.2e-141 Ras-GEF domain-containing family member 1B-A OS=Danio rerio GN=rasgef1ba PE=2 SV=2 PF00617//PF00412//PF02209//PF13639 RasGEF domain//LIM domain//Villin headpiece domain//Ring finger domain GO:0007264//GO:0007010//GO:0043087 small GTPase mediated signal transduction//cytoskeleton organization//regulation of GTPase activity GO:0005515//GO:0003779//GO:0005085//GO:0008270 protein binding//actin binding//guanyl-nucleotide exchange factor activity//zinc ion binding -- -- KOG3541 Predicted guanine nucleotide exchange factor Cluster-8309.38545 BP_3 8.00 2.03 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38546 BP_3 1590.57 10.38 7678 642923618 XP_008193579.1 8967 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: dedicator of cytokinesis protein 9 [Tribolium castaneum] 815808572 XM_012369703.1 116 1.14827e-50 PREDICTED: Linepithema humile dedicator of cytokinesis protein 9 (LOC105673797), transcript variant X4, mRNA -- -- -- -- Q9BZ29 4203 0.0e+00 Dedicator of cytokinesis protein 9 OS=Homo sapiens GN=DOCK9 PE=1 SV=2 PF02183//PF03810 Homeobox associated leucine zipper//Importin-beta N-terminal domain GO:0006886//GO:0006355 intracellular protein transport//regulation of transcription, DNA-templated GO:0003700//GO:0008536//GO:0043565 transcription factor activity, sequence-specific DNA binding//Ran GTPase binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG1997 PH domain-containing protein Cluster-8309.38547 BP_3 715.51 55.60 912 166851824 NP_001107778.1 400 2.4e-36 cuticular protein analogous to peritrophins 3-C5 isoform 2 precursor [Tribolium castaneum]>gi|119387890|gb|ABL73930.1| obstractor C2 [Tribolium castaneum] 780672324 XM_011697243.1 79 4.88634e-31 PREDICTED: Wasmannia auropunctata uncharacterized LOC105454569 (LOC105454569), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.38548 BP_3 20.00 0.64 1797 695189911 AIT11911.1 1772 3.9e-195 endo-beta-1,4-glucanase [Parasesarma erythrodactyla] 292683084 AK339636.1 45 7.79569e-12 Lotus japonicus cDNA, clone: LjFL3-041-DF07, HTC -- -- -- -- P26221 966 4.7e-103 Endoglucanase E-4 OS=Thermobifida fusca GN=celD PE=1 SV=2 PF00759 Glycosyl hydrolase family 9 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.38550 BP_3 14.92 0.74 1269 189238490 XP_001809098.1 336 9.0e-29 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|642926357|ref|XP_008194892.1| PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07973 Threonyl and Alanyl tRNA synthetase second additional domain GO:0043039 tRNA aminoacylation GO:0005524//GO:0016876 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds -- -- -- -- Cluster-8309.38551 BP_3 417.00 8.42 2678 91093142 XP_969809.1 3019 0.0e+00 PREDICTED: cell division cycle protein 27 homolog [Tribolium castaneum]>gi|270003019|gb|EEZ99466.1| hypothetical protein TcasGA2_TC000032 [Tribolium castaneum] -- -- -- -- -- K03350 APC3, CDC27 anaphase-promoting complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03350 A7Z061 1579 5.7e-174 Cell division cycle protein 27 homolog OS=Bos taurus GN=CDC27 PE=2 SV=1 PF13181//PF13174//PF13374//PF00515//PF13371//PF13414//PF01139//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//tRNA-splicing ligase RtcB//Tetratricopeptide repeat GO:0006396 RNA processing GO:0005515//GO:0008452 protein binding//RNA ligase activity -- -- KOG1126 DNA-binding cell division cycle control protein Cluster-8309.38552 BP_3 23.55 0.47 2732 642926359 XP_008194893.1 977 9.1e-103 PREDICTED: intracellular protein transport protein USO1-like isoform X2 [Tribolium castaneum]>gi|270009056|gb|EFA05504.1| hypothetical protein TcasGA2_TC015690 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08799 136 1.2e-06 Myosin-2 heavy chain OS=Dictyostelium discoideum GN=mhcA PE=1 SV=3 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38555 BP_3 1781.00 44.54 2219 146411532 ABQ39970.1 2682 1.5e-300 heat shock protein 70 [Anatolica polita borealis] 402235128 JQ693015.1 483 0 Plutella xylostella Hsp72-1a mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 O97125 2454 1.6e-275 Heat shock protein 68 OS=Drosophila melanogaster GN=Hsp68 PE=1 SV=1 PF09326//PF06723//PF02782//PF01968 NADH-ubiquinone oxidoreductase subunit G, C-terminal//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//Hydantoinase/oxoprolinase GO:0055114//GO:0005975//GO:0000902 oxidation-reduction process//carbohydrate metabolic process//cell morphogenesis GO:0016651//GO:0016773//GO:0051536//GO:0016787 oxidoreductase activity, acting on NAD(P)H//phosphotransferase activity, alcohol group as acceptor//iron-sulfur cluster binding//hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.38558 BP_3 1.00 0.37 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38560 BP_3 824.45 11.42 3771 282165741 NP_001164113.1 2645 4.8e-296 cap-n-collar [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 5.4e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF03131//PF03126//PF07716//PF00170 bZIP Maf transcription factor//Plus-3 domain//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3863 bZIP transcription factor NRF1 Cluster-8309.38563 BP_3 2.00 0.67 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38564 BP_3 660.97 10.99 3190 270012994 EFA09442.1 794 1.8e-81 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38566 BP_3 367.35 7.01 2817 642923441 XP_008193745.1 2035 2.0e-225 PREDICTED: intraflagellar transport protein 80 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2H3 1238 2.1e-134 Intraflagellar transport protein 80 homolog OS=Homo sapiens GN=IFT80 PE=1 SV=3 PF04421//PF01239 Mss4 protein//Protein prenyltransferase alpha subunit repeat GO:0018342//GO:0043087//GO:0007264 protein prenylation//regulation of GTPase activity//small GTPase mediated signal transduction GO:0008318//GO:0005085 protein prenyltransferase activity//guanyl-nucleotide exchange factor activity -- -- KOG0529 Protein geranylgeranyltransferase type II, alpha subunit Cluster-8309.38567 BP_3 169.99 2.80 3218 478263360 ENN81736.1 393 5.6e-35 hypothetical protein YQE_01875, partial [Dendroctonus ponderosae]>gi|546681308|gb|ERL91422.1| hypothetical protein D910_08754 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.38568 BP_3 12.73 0.42 1751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38569 BP_3 20.77 0.40 2815 642928048 XP_008200135.1 909 7.2e-95 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 2.6e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF04986//PF00038//PF04508//PF10473//PF01008//PF09392 Putative transposase//Intermediate filament protein//Viral A-type inclusion protein repeat//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Initiation factor 2 subunit family//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0015031//GO:0044237//GO:0006313//GO:0016032//GO:0009405 protein transport//cellular metabolic process//transposition, DNA-mediated//viral process//pathogenesis GO:0004803//GO:0042803//GO:0045502//GO:0008134//GO:0005198//GO:0003677 transposase activity//protein homodimerization activity//dynein binding//transcription factor binding//structural molecule activity//DNA binding GO:0005882//GO:0005667//GO:0030286 intermediate filament//transcription factor complex//dynein complex -- -- Cluster-8309.38570 BP_3 1.00 8.38 248 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38571 BP_3 60.82 0.50 6113 478258440 ENN78530.1 458 3.1e-42 hypothetical protein YQE_05004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478//PF01442//PF04210//PF02601 Prominin//Apolipoprotein A1/A4/E domain//Tetrahydromethanopterin S-methyltransferase, subunit G//Exonuclease VII, large subunit GO:0042157//GO:0015948//GO:0046656//GO:0006869//GO:0006308 lipoprotein metabolic process//methanogenesis//folic acid biosynthetic process//lipid transport//DNA catabolic process GO:0030269//GO:0008289//GO:0008855 tetrahydromethanopterin S-methyltransferase activity//lipid binding//exodeoxyribonuclease VII activity GO:0016021//GO:0005576//GO:0009318 integral component of membrane//extracellular region//exodeoxyribonuclease VII complex -- -- Cluster-8309.38572 BP_3 96.52 6.04 1062 189240524 XP_971875.2 535 6.3e-52 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] 808139336 XM_003400646.2 152 1.50316e-71 PREDICTED: Bombus terrestris 60S ribosomal protein L3 (LOC100646559), mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 487 9.6e-48 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.38573 BP_3 64.00 3.81 1102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38574 BP_3 14.00 0.32 2382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38578 BP_3 169.74 0.50 16494 478252141 ENN72570.1 13658 0.0e+00 hypothetical protein YQE_10792, partial [Dendroctonus ponderosae] 827541853 XM_012688670.1 160 8.58255e-75 PREDICTED: Bombyx mori low-density lipoprotein receptor-related protein 2-like (LOC101739353), mRNA K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 P98158 6394 0.0e+00 Low-density lipoprotein receptor-related protein 2 OS=Rattus norvegicus GN=Lrp2 PE=1 SV=1 PF01731//PF09246//PF00057//PF00008//PF07645 Arylesterase//PHAT//Low-density lipoprotein receptor domain class A//EGF-like domain//Calcium-binding EGF domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0004064//GO:0005509//GO:0003723 protein binding//arylesterase activity//calcium ion binding//RNA binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38579 BP_3 9783.57 32.34 14873 498980679 XP_004529416.1 18931 0.0e+00 PREDICTED: low-density lipoprotein receptor-related protein 2 [Ceratitis capitata]>gi|498980683|ref|XP_004529417.1| PREDICTED: low-density lipoprotein receptor-related protein 2 [Ceratitis capitata] 665794659 XM_008546814.1 316 1.47454e-161 PREDICTED: Microplitis demolitor low-density lipoprotein receptor-related protein 2 (LOC103569491), mRNA K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 P98158 9274 0.0e+00 Low-density lipoprotein receptor-related protein 2 OS=Rattus norvegicus GN=Lrp2 PE=1 SV=1 PF00008//PF07645//PF00057//PF09246//PF01731 EGF-like domain//Calcium-binding EGF domain//Low-density lipoprotein receptor domain class A//PHAT//Arylesterase GO:0006355 regulation of transcription, DNA-templated GO:0004064//GO:0005515//GO:0005509//GO:0003723 arylesterase activity//protein binding//calcium ion binding//RNA binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38581 BP_3 178.04 0.84 10493 642917842 XP_008191308.1 2642 3.0e-295 PREDICTED: serine/threonine-protein kinase MARK2 isoform X6 [Tribolium castaneum] 642917841 XM_008193086.1 688 0 PREDICTED: Tribolium castaneum par-1 protein kinase (LOC656926), transcript variant X7, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 Q8VHJ5 1427 9.5e-156 Serine/threonine-protein kinase MARK1 OS=Mus musculus GN=Mark1 PE=1 SV=2 PF00069//PF06293//PF07714//PF00802 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Pneumovirus attachment glycoprotein G GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020//GO:0055036 membrane//virion membrane KOG0586 Serine/threonine protein kinase Cluster-8309.38582 BP_3 3548.78 18.78 9399 642917848 XP_008191311.1 2512 3.2e-280 PREDICTED: serine/threonine-protein kinase MARK2 isoform X9 [Tribolium castaneum] 642917841 XM_008193086.1 688 0 PREDICTED: Tribolium castaneum par-1 protein kinase (LOC656926), transcript variant X7, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 Q8VHJ5 1427 8.5e-156 Serine/threonine-protein kinase MARK1 OS=Mus musculus GN=Mark1 PE=1 SV=2 PF00802//PF07714//PF04310//PF06293//PF00069 Pneumovirus attachment glycoprotein G//Protein tyrosine kinase//MukB N-terminal//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0030261//GO:0007059//GO:0006468 chromosome condensation//chromosome segregation//protein phosphorylation GO:0004672//GO:0016773//GO:0003677//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//DNA binding//ATP binding GO:0016020//GO:0009295//GO:0055036 membrane//nucleoid//virion membrane KOG0586 Serine/threonine protein kinase Cluster-8309.38583 BP_3 74.37 0.57 6608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.38585 BP_3 32.85 3.14 796 332375004 AEE62643.1 598 2.4e-59 unknown [Dendroctonus ponderosae]>gi|478258425|gb|ENN78519.1| hypothetical protein YQE_05012, partial [Dendroctonus ponderosae]>gi|546676434|gb|ERL87445.1| hypothetical protein D910_04837 [Dendroctonus ponderosae] -- -- -- -- -- K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 268 1.8e-22 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 PF02936 Cytochrome c oxidase subunit IV GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.38586 BP_3 706.15 7.13 5067 91087225 XP_975488.1 2701 2.1e-302 PREDICTED: N-terminal kinase-like protein [Tribolium castaneum] 642929977 XM_970395.2 495 0 PREDICTED: Tribolium castaneum N-terminal kinase-like protein (LOC664388), mRNA K08876 SCYL1 SCY1-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08876 Q28FH2 1597 8.9e-176 N-terminal kinase-like protein OS=Xenopus tropicalis GN=scyl1 PE=2 SV=1 PF01602//PF07714//PF00069//PF02985 Adaptin N terminal region//Protein tyrosine kinase//Protein kinase domain//HEAT repeat GO:0006886//GO:0016192//GO:0006468 intracellular protein transport//vesicle-mediated transport//protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding GO:0030117 membrane coat KOG1243 Protein kinase Cluster-8309.38587 BP_3 363.52 3.63 5120 91087225 XP_975488.1 2526 4.1e-282 PREDICTED: N-terminal kinase-like protein [Tribolium castaneum] 642929977 XM_970395.2 479 0 PREDICTED: Tribolium castaneum N-terminal kinase-like protein (LOC664388), mRNA K08876 SCYL1 SCY1-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08876 Q28FH2 1530 5.3e-168 N-terminal kinase-like protein OS=Xenopus tropicalis GN=scyl1 PE=2 SV=1 PF01602//PF02985 Adaptin N terminal region//HEAT repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117 membrane coat KOG1243 Protein kinase Cluster-8309.38588 BP_3 1620.00 5.83 13689 478254656 ENN74897.1 12128 0.0e+00 hypothetical protein YQE_08475, partial [Dendroctonus ponderosae] 611970121 XM_007480100.1 108 5.74467e-46 PREDICTED: Monodelphis domestica HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1), mRNA K10594 HERC1 E3 ubiquitin-protein ligase HERC1 http://www.genome.jp/dbget-bin/www_bget?ko:K10594 Q15751 3927 0.0e+00 Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens GN=HERC1 PE=1 SV=2 PF06817//PF00400//PF01475//PF00632//PF00622 Reverse transcriptase thumb domain//WD domain, G-beta repeat//Ferric uptake regulator family//HECT-domain (ubiquitin-transferase)//SPRY domain GO:0006355//GO:0016567//GO:0006278 regulation of transcription, DNA-templated//protein ubiquitination//RNA-dependent DNA replication GO:0003700//GO:0005515//GO:0004842//GO:0003964 transcription factor activity, sequence-specific DNA binding//protein binding//ubiquitin-protein transferase activity//RNA-directed DNA polymerase activity GO:0005667 transcription factor complex KOG1426 FOG: RCC1 domain Cluster-8309.38589 BP_3 453.77 5.15 4539 91077758 XP_967802.1 1416 1.9e-153 PREDICTED: fructose-1,6-bisphosphatase 1 [Tribolium castaneum]>gi|270002228|gb|EEZ98675.1| hypothetical protein TcasGA2_TC001209 [Tribolium castaneum] 229367525 BT083036.1 55 5.49851e-17 Anoplopoma fimbria clone afim-evh-526-250 Fructose-1,6-bisphosphatase 1 putative mRNA, complete cds K03841 FBP, fbp fructose-1,6-bisphosphatase I http://www.genome.jp/dbget-bin/www_bget?ko:K03841 Q3SZB7 1017 1.4e-108 Fructose-1,6-bisphosphatase 1 OS=Bos taurus GN=FBP1 PE=2 SV=3 PF00316//PF00459//PF13181//PF00515//PF13414//PF13174 Fructose-1-6-bisphosphatase//Inositol monophosphatase family//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006098//GO:0006096//GO:0015976//GO:0006094//GO:0005975//GO:0006000//GO:0046854//GO:0006013 pentose-phosphate shunt//glycolytic process//carbon utilization//gluconeogenesis//carbohydrate metabolic process//fructose metabolic process//phosphatidylinositol phosphorylation//mannose metabolic process GO:0042132//GO:0005515//GO:0042578 fructose 1,6-bisphosphate 1-phosphatase activity//protein binding//phosphoric ester hydrolase activity -- -- KOG1458 Fructose-1,6-bisphosphatase Cluster-8309.3859 BP_3 2.00 1.37 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38590 BP_3 501.00 21.27 1427 91085271 XP_967089.1 1437 2.2e-156 PREDICTED: GDP-L-fucose synthase [Tribolium castaneum]>gi|270008444|gb|EFA04892.1| hypothetical protein TcasGA2_TC014956 [Tribolium castaneum] -- -- -- -- -- K02377 TSTA3, fcl GDP-L-fucose synthase http://www.genome.jp/dbget-bin/www_bget?ko:K02377 Q8K3X2 1145 6.5e-124 GDP-L-fucose synthase OS=Cricetulus griseus GN=TSTA3 PE=2 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0044237//GO:0008210 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//cellular metabolic process//estrogen metabolic process GO:0000166//GO:0016616//GO:0003824//GO:0050662//GO:0003854 nucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1431 GDP-L-fucose synthetase Cluster-8309.38591 BP_3 200.79 1.35 7465 270012248 EFA08696.1 940 4.9e-98 hypothetical protein TcasGA2_TC006367 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q8IX06 586 2.2e-58 Putative exonuclease GOR OS=Homo sapiens GN=REXO1L1P PE=5 SV=2 PF02932//PF01612//PF00930//PF00400 Neurotransmitter-gated ion-channel transmembrane region//3'-5' exonuclease//Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006811//GO:0006139//GO:0006508 ion transport//nucleobase-containing compound metabolic process//proteolysis GO:0005515//GO:0008408//GO:0003676 protein binding//3'-5' exonuclease activity//nucleic acid binding GO:0016020 membrane KOG2248 3'-5' exonuclease Cluster-8309.38592 BP_3 82.10 1.26 3424 642940096 XP_008192965.1 1556 8.3e-170 PREDICTED: paxillin isoform X6 [Tribolium castaneum]>gi|270016014|gb|EFA12462.1| hypothetical protein TcasGA2_TC010609 [Tribolium castaneum] 665811408 XM_008555945.1 200 1.02714e-97 PREDICTED: Microplitis demolitor leupaxin-like (LOC103575940), mRNA K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 P49024 851 1.9e-89 Paxillin OS=Gallus gallus GN=PXN PE=1 SV=1 PF04216//PF05923//PF00412 Protein involved in formate dehydrogenase formation//APC cysteine-rich region//LIM domain GO:0016055 Wnt signaling pathway GO:0008270//GO:0043169 zinc ion binding//cation binding GO:0005737 cytoplasm KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.38593 BP_3 14.41 0.38 2138 270005756 EFA02204.1 1090 5.6e-116 hypothetical protein TcasGA2_TC007862 [Tribolium castaneum] 642919215 XM_963943.3 240 3.70498e-120 PREDICTED: Tribolium castaneum uncharacterized LOC657485 (LOC657485), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38594 BP_3 3.45 0.56 587 270005756 EFA02204.1 409 1.4e-37 hypothetical protein TcasGA2_TC007862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38596 BP_3 2211.56 37.61 3126 642913083 XP_008201383.1 2737 8.6e-307 PREDICTED: disks large 1 tumor suppressor protein isoform X7 [Tribolium castaneum] 755966655 XM_011307270.1 318 2.37579e-163 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X5, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 2147 9.2e-240 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF14604//PF00018//PF13180 PDZ domain (Also known as DHR or GLGF)//Variant SH3 domain//SH3 domain//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.38599 BP_3 406.05 7.38 2945 270001944 EEZ98391.1 2260 1.7e-251 hypothetical protein TcasGA2_TC000855 [Tribolium castaneum] 755966655 XM_011307270.1 318 2.23662e-163 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X5, mRNA K12075 DLG2_3 discs large protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12075 P31007 1822 4.2e-202 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00018//PF14604//PF00595 PDZ domain//SH3 domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.386 BP_3 6.00 0.56 806 646707896 KDR14423.1 741 6.2e-76 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [Zootermopsis nevadensis] 543376236 XM_005531270.1 126 3.2059e-57 PREDICTED: Pseudopodoces humilis NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (NDUFS7), mRNA K03940 NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03940 P0CB83 626 5.5e-64 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Pongo abelii GN=NDUFS7 PE=2 SV=1 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit GO:0055114 oxidation-reduction process GO:0051536 iron-sulfur cluster binding -- -- KOG1687 NADH-ubiquinone oxidoreductase, NUFS7/PSST/20 kDa subunit Cluster-8309.38601 BP_3 1302.65 20.70 3325 91085925 XP_969990.1 570 1.7e-55 PREDICTED: charged multivesicular body protein 4b [Tribolium castaneum]>gi|270009953|gb|EFA06401.1| hypothetical protein TcasGA2_TC009279 [Tribolium castaneum] 827540193 XM_004923412.2 101 1.07782e-42 PREDICTED: Bombyx mori charged multivesicular body protein 4b (LOC101737568), mRNA K12194 CHMP4, SNF7, VPS32 charged multivesicular body protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12194 Q6IQ73 457 9.1e-44 Charged multivesicular body protein 4c OS=Danio rerio GN=chmp4c PE=2 SV=1 PF03357//PF01920//PF02993//PF00293//PF08707//PF04053//PF09177//PF00015 Snf7//Prefoldin subunit//Minor capsid protein VI//NUDIX domain//Primase C terminal 2 (PriCT-2)//Coatomer WD associated region//Syntaxin 6, N-terminal//Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0006457//GO:0007165//GO:0006886//GO:0016192//GO:0048193//GO:0007034 protein folding//signal transduction//intracellular protein transport//vesicle-mediated transport//Golgi vesicle transport//vacuolar transport GO:0016787//GO:0005198//GO:0004871//GO:0051082//GO:0016817 hydrolase activity//structural molecule activity//signal transducer activity//unfolded protein binding//hydrolase activity, acting on acid anhydrides GO:0019028//GO:0016020//GO:0030117//GO:0016272 viral capsid//membrane//membrane coat//prefoldin complex KOG1656 Protein involved in glucose derepression and pre-vacuolar endosome protein sorting Cluster-8309.38604 BP_3 30.85 0.61 2717 91086165 XP_970259.1 1883 8.0e-208 PREDICTED: ATP-dependent zinc metalloprotease YME1 homolog [Tribolium castaneum]>gi|270009883|gb|EFA06331.1| hypothetical protein TcasGA2_TC009202 [Tribolium castaneum] 759074133 XM_011348443.1 83 8.91098e-33 PREDICTED: Cerapachys biroi ATP-dependent zinc metalloprotease YME1 homolog (LOC105284713), transcript variant X3, mRNA K08955 YME1 ATP-dependent metalloprotease http://www.genome.jp/dbget-bin/www_bget?ko:K08955 P54813 1316 1.8e-143 ATP-dependent zinc metalloprotease YME1 homolog OS=Caenorhabditis elegans GN=ymel-1 PE=3 SV=2 PF10415//PF01434//PF00004 Fumarase C C-terminus//Peptidase family M41//ATPase family associated with various cellular activities (AAA) GO:0030163//GO:0006099//GO:0006508 protein catabolic process//tricarboxylic acid cycle//proteolysis GO:0016829//GO:0017111//GO:0005524//GO:0004222 lyase activity//nucleoside-triphosphatase activity//ATP binding//metalloendopeptidase activity GO:0016020 membrane KOG0734 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.38605 BP_3 154.00 2.88 2865 91078618 XP_967724.1 1634 6.3e-179 PREDICTED: cytochrome P450 4d2 [Tribolium castaneum]>gi|270004875|gb|EFA01323.1| cytochrome P450 4BR3 [Tribolium castaneum] 689542312 LL999114.1 35 4.53226e-06 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_contig0000050 K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 938 1.3e-99 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016491//GO:0005506//GO:0046872//GO:0020037//GO:0016705 oxidoreductase activity//iron ion binding//metal ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.38606 BP_3 15026.51 169.49 4565 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF03144//PF00983//PF01926 Elongation factor G, domain IV//Elongation factor Tu domain 2//Tymovirus coat protein//50S ribosome-binding GTPase -- -- GO:0005525//GO:0005198 GTP binding//structural molecule activity GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.38609 BP_3 276.16 2.01 6921 642925954 XP_008195644.1 2092 1.2e-231 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 1367 5.7e-149 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF00076//PF00309//PF01429//PF01400//PF01073//PF00642//PF03015//PF01480//PF01370 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Sigma-54 factor, Activator interacting domain (AID)//Methyl-CpG binding domain//Astacin (Peptidase family M12A)//3-beta hydroxysteroid dehydrogenase/isomerase family//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Male sterility protein//PWI domain//NAD dependent epimerase/dehydratase family GO:0008210//GO:0006397//GO:0006351//GO:0006144//GO:0006206//GO:0006508//GO:0006352//GO:0008207//GO:0006355//GO:0008209//GO:0055114//GO:0006694 estrogen metabolic process//mRNA processing//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//proteolysis//DNA-templated transcription, initiation//C21-steroid hormone metabolic process//regulation of transcription, DNA-templated//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0003677//GO:0003824//GO:0003676//GO:0016987//GO:0046872//GO:0050662//GO:0003899//GO:0003854//GO:0004222//GO:0016616//GO:0080019//GO:0003700 DNA binding//catalytic activity//nucleic acid binding//sigma factor activity//metal ion binding//coenzyme binding//DNA-directed RNA polymerase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//metalloendopeptidase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005730 nucleus//transcription factor complex//nucleolus KOG1221 Acyl-CoA reductase Cluster-8309.38611 BP_3 443.25 3.30 6765 642926040 XP_008194740.1 9411 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 852 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 6832 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF02655//PF02786//PF07478//PF08326 ATP-grasp domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus//Acetyl-CoA carboxylase, central region GO:0006090//GO:0009252//GO:0006633//GO:0046436 pyruvate metabolic process//peptidoglycan biosynthetic process//fatty acid biosynthetic process//D-alanine metabolic process GO:0003989//GO:0008716//GO:0046872//GO:0005524 acetyl-CoA carboxylase activity//D-alanine-D-alanine ligase activity//metal ion binding//ATP binding GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.38612 BP_3 6087.91 66.55 4701 642931172 XP_008196469.1 2267 4.1e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38613 BP_3 121.62 2.26 2888 642915594 XP_008190680.1 519 1.2e-49 PREDICTED: uncharacterized protein LOC655748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02655//PF01077 ATP-grasp domain//Nitrite and sulphite reductase 4Fe-4S domain GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0020037//GO:0005524//GO:0051536 metal ion binding//oxidoreductase activity//heme binding//ATP binding//iron-sulfur cluster binding -- -- -- -- Cluster-8309.38614 BP_3 236.49 3.26 3785 642913883 XP_975200.2 1541 5.0e-168 PREDICTED: forkhead box protein O isoform X1 [Tribolium castaneum] 642913884 XM_008202979.1 252 1.40917e-126 PREDICTED: Tribolium castaneum forkhead box protein O (LOC664090), transcript variant X2, mRNA K09408 FOXO3 forkhead box protein O3 http://www.genome.jp/dbget-bin/www_bget?ko:K09408 B4MB78 905 1.2e-95 Forkhead box protein O OS=Drosophila virilis GN=foxo PE=3 SV=1 PF01342//PF00250 SAND domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.38615 BP_3 51.34 0.84 3226 332376929 AEE63604.1 1043 2.4e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05319 445 2.2e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38616 BP_3 3044.76 65.01 2549 332376929 AEE63604.1 1043 1.9e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05319 445 1.7e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38618 BP_3 133.78 4.16 1843 91081907 XP_970048.1 2043 1.5e-226 PREDICTED: myotubularin-related protein 9 isoform X2 [Tribolium castaneum]>gi|270007347|gb|EFA03795.1| hypothetical protein TcasGA2_TC013907 [Tribolium castaneum] -- -- -- -- -- K18084 MTMR9 myotubularin-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18084 Q96QG7 1404 7.8e-154 Myotubularin-related protein 9 OS=Homo sapiens GN=MTMR9 PE=1 SV=1 -- -- GO:0016311 dephosphorylation GO:0016791 phosphatase activity -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.38620 BP_3 506.58 8.07 3318 642929941 XP_008196035.1 1619 4.0e-177 PREDICTED: nucleolar protein 4-like isoform X3 [Tribolium castaneum] 817216939 XM_012429042.1 117 1.37174e-51 PREDICTED: Orussus abietinus nucleolar protein 4-like (LOC105701897), transcript variant X4, mRNA -- -- -- -- Q96MY1 448 1.0e-42 Nucleolar protein 4-like OS=Homo sapiens GN=NOL4L PE=1 SV=2 PF03607//PF09026 Doublecortin//Centromere protein B dimerisation domain GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0003682 DNA binding//chromatin binding GO:0005634//GO:0000785//GO:0000775 nucleus//chromatin//chromosome, centromeric region -- -- Cluster-8309.38621 BP_3 566.18 2.61 10763 270010025 EFA06473.1 8604 0.0e+00 hypothetical protein TcasGA2_TC009358 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.63484e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF09141//PF01025//PF01044//PF02174//PF01608 Talin, middle domain//GrpE//Vinculin family//PTB domain (IRS-1 type)//I/LWEQ domain GO:0007016//GO:0007165//GO:0006457//GO:0007155 cytoskeletal anchoring at plasma membrane//signal transduction//protein folding//cell adhesion GO:0003779//GO:0005158//GO:0005200//GO:0042803//GO:0051087//GO:0000774//GO:0051015 actin binding//insulin receptor binding//structural constituent of cytoskeleton//protein homodimerization activity//chaperone binding//adenyl-nucleotide exchange factor activity//actin filament binding GO:0005899//GO:0001726//GO:0005856//GO:0005925 insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.38625 BP_3 1049.00 25.81 2251 91082293 XP_973907.1 1943 7.3e-215 PREDICTED: DEAD-box helicase Dbp80 [Tribolium castaneum]>gi|270007465|gb|EFA03913.1| hypothetical protein TcasGA2_TC014047 [Tribolium castaneum] -- -- -- -- -- K18655 DDX19, DBP5 ATP-dependent RNA helicase DDX19/DBP5 http://www.genome.jp/dbget-bin/www_bget?ko:K18655 O61305 1654 9.7e-183 DEAD-box helicase Dbp80 OS=Drosophila melanogaster GN=Dbp80 PE=1 SV=1 PF04851//PF00539//PF00270 Type III restriction enzyme, res subunit//Transactivating regulatory protein (Tat)//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003700//GO:0003677//GO:0016787//GO:0005524//GO:0008026 nucleic acid binding//transcription factor activity, sequence-specific DNA binding//DNA binding//hydrolase activity//ATP binding//ATP-dependent helicase activity GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG0332 ATP-dependent RNA helicase Cluster-8309.38630 BP_3 664.68 9.13 3800 642922280 XP_008193091.1 2505 8.3e-280 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.7e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- KOG3731 Sulfatases Cluster-8309.38631 BP_3 23.10 0.99 1419 642922284 XP_008193093.1 1162 1.7e-124 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 715 4.7e-74 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- KOG3731 Sulfatases Cluster-8309.38634 BP_3 501.80 18.32 1612 646717218 KDR20164.1 788 4.4e-81 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 5.06098e-58 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 1.0e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00313//PF16367//PF00076 'Cold-shock' DNA-binding domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.38635 BP_3 774.75 13.16 3129 91088017 XP_974079.1 1338 1.4e-144 PREDICTED: graves disease carrier protein [Tribolium castaneum]>gi|270011890|gb|EFA08338.1| hypothetical protein TcasGA2_TC005981 [Tribolium castaneum] -- -- -- -- -- K15084 SLC25A16, GDA, LEU5 solute carrier family 25 (mitochondrial carrier protein), member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15084 Q8C0K5 814 3.4e-85 Graves disease carrier protein homolog OS=Mus musculus GN=Slc25a16 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0005743//GO:0016021 mitochondrial inner membrane//integral component of membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.38636 BP_3 242.14 7.81 1786 91088017 XP_974079.1 780 4.2e-80 PREDICTED: graves disease carrier protein [Tribolium castaneum]>gi|270011890|gb|EFA08338.1| hypothetical protein TcasGA2_TC005981 [Tribolium castaneum] -- -- -- -- -- K15084 SLC25A16, GDA, LEU5 solute carrier family 25 (mitochondrial carrier protein), member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15084 Q8C0K5 450 3.2e-43 Graves disease carrier protein homolog OS=Mus musculus GN=Slc25a16 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.38638 BP_3 25.01 0.75 1908 91091818 XP_966528.1 1242 1.2e-133 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 871 5.1e-92 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006810//GO:0007268//GO:0007165//GO:0006811 transport//synaptic transmission//signal transduction//ion transport GO:0005234//GO:0004970//GO:0005215 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//transporter activity GO:0016020 membrane -- -- Cluster-8309.38639 BP_3 223.70 2.48 4645 91092690 XP_971771.1 1842 7.7e-203 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 5.09725e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K04454 MEF2C MADS-box transcription enhancer factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K04454 P40791 956 1.7e-101 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.38640 BP_3 153.35 1.27 6091 270014864 EFA11312.1 1414 4.3e-153 hypothetical protein TcasGA2_TC010850 [Tribolium castaneum] 826471828 XM_012680836.1 139 1.49113e-63 PREDICTED: Monomorium pharaonis myocyte-specific enhancer factor 2 (LOC105836654), transcript variant X5, mRNA K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 521 6.3e-51 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF00319//PF03554 SRF-type transcription factor (DNA-binding and dimerisation domain)//UL73 viral envelope glycoprotein -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.38641 BP_3 37.04 0.37 5165 642911378 XP_008199399.1 1149 2.0e-122 PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911380|ref|XP_008199400.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911382|ref|XP_008199401.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911384|ref|XP_008199402.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911386|ref|XP_008199403.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911388|ref|XP_008199404.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum] 642911387 XM_008201182.1 382 0 PREDICTED: Tribolium castaneum myocyte-specific enhancer factor 2 (LOC660448), transcript variant X6, mRNA K04454 MEF2C MADS-box transcription enhancer factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K04454 P40791 832 4.6e-87 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF00319//PF03554 SRF-type transcription factor (DNA-binding and dimerisation domain)//UL73 viral envelope glycoprotein -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.38645 BP_3 450.32 4.19 5473 91080669 XP_975087.1 970 1.2e-101 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 746866518 XM_011066023.1 149 3.6965e-69 PREDICTED: Acromyrmex echinatior vesicle-trafficking protein SEC22b (LOC105152004), transcript variant X3, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 719 6.2e-74 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.38646 BP_3 20.56 1.45 975 642933931 XP_008197572.1 535 5.8e-52 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 214 4.0e-16 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 PF02724//PF11081 CDC45-like protein//Protein of unknown function (DUF2890) GO:0016032//GO:0006270 viral process//DNA replication initiation -- -- -- -- -- -- Cluster-8309.38647 BP_3 467.51 6.66 3675 91078854 XP_971956.1 810 2.8e-83 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit C [Tribolium castaneum]>gi|270004131|gb|EFA00579.1| hypothetical protein TcasGA2_TC003449 [Tribolium castaneum] 242023017 XM_002431888.1 35 5.82994e-06 Pediculus humanus corporis Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative, mRNA K03859 PIGC, GPI2 phosphatidylinositol glycan, class C http://www.genome.jp/dbget-bin/www_bget?ko:K03859 Q92535 456 1.3e-43 Phosphatidylinositol N-acetylglucosaminyltransferase subunit C OS=Homo sapiens GN=PIGC PE=2 SV=1 PF01158//PF06432 Ribosomal protein L36e//Phosphatidylinositol N-acetylglucosaminyltransferase GO:0006412//GO:0006506//GO:0042254 translation//GPI anchor biosynthetic process//ribosome biogenesis GO:0017176//GO:0003735 phosphatidylinositol N-acetylglucosaminyltransferase activity//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622 integral component of membrane//ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-8309.38649 BP_3 1150.33 14.90 4014 642923252 XP_008193678.1 4688 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 390178834 XM_001359343.3 125 5.93776e-56 Drosophila pseudoobscura pseudoobscura GA18295 (Dpse\GA18295), partial mRNA K01191 E3.2.1.24 alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01191 Q8BRK9 1596 9.2e-176 Alpha-mannosidase 2x OS=Mus musculus GN=Man2a2 PE=2 SV=2 PF09261//PF07748//PF01074 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0008270//GO:0004553//GO:0004559//GO:0015923 zinc ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-mannosidase activity//mannosidase activity -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.38650 BP_3 369.00 7.21 2757 440908077 ELR58138.1 1057 4.9e-112 Insulin enhancer protein ISL-1, partial [Bos mutus] 194758652 XM_001961540.1 171 1.09e-81 Drosophila ananassae GF14867 (Dana\GF14867), mRNA K09370 ISL1 insulin gene enhancer protein ISL-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09370 P50211 1050 1.3e-112 Insulin gene enhancer protein ISL-1 OS=Gallus gallus GN=ISL1 PE=2 SV=1 PF00046//PF12300//PF05920//PF06305//PF00412 Homeobox domain//Protein of unknown function (DUF3628)//Homeobox KN domain//Protein of unknown function (DUF1049)//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0016817//GO:0003677//GO:0008270 hydrolase activity, acting on acid anhydrides//DNA binding//zinc ion binding GO:0005887 integral component of plasma membrane KOG0490 Transcription factor, contains HOX domain Cluster-8309.38653 BP_3 146.42 0.35 20177 642937892 XP_008200345.1 16472 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 3.67229e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 9599 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF02207//PF04410//PF03875//PF02806//PF01667//PF03488 Putative zinc finger in N-recognin (UBR box)//Gar1/Naf1 RNA binding region//Statherin//Alpha amylase, C-terminal all-beta domain//Ribosomal protein S27//Nematode insulin-related peptide beta type GO:0006412//GO:0042742//GO:0030500//GO:0007165//GO:0005975//GO:0001522//GO:0042254 translation//defense response to bacterium//regulation of bone mineralization//signal transduction//carbohydrate metabolic process//pseudouridine synthesis//ribosome biogenesis GO:0005179//GO:0003824//GO:0043169//GO:0046848//GO:0003735//GO:0008270 hormone activity//catalytic activity//cation binding//hydroxyapatite binding//structural constituent of ribosome//zinc ion binding GO:0005576//GO:0005622//GO:0005840 extracellular region//intracellular//ribosome KOG1776 Zn-binding protein Push Cluster-8309.38657 BP_3 2386.36 10.93 10813 270001100 EEZ97547.1 2545 5.5e-284 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] 170032990 XM_001844311.1 225 4.13604e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 1.0e-216 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF13855//PF14304//PF00595//PF01378//PF13180//PF00412//PF10468//PF00560 Leucine rich repeat//Transcription termination and cleavage factor C-terminal//PDZ domain (Also known as DHR or GLGF)//B domain//PDZ domain//LIM domain//Carboxypeptidase inhibitor I68//Leucine Rich Repeat GO:0010951//GO:0031124//GO:0007596 negative regulation of endopeptidase activity//mRNA 3'-end processing//blood coagulation GO:0008270//GO:0008191//GO:0005515 zinc ion binding//metalloendopeptidase inhibitor activity//protein binding GO:0005618 cell wall KOG0619 FOG: Leucine rich repeat Cluster-8309.38658 BP_3 314.05 5.53 3030 820805524 AKG92753.1 937 4.4e-98 mnt1 [Leptinotarsa decemlineata] -- -- -- -- -- K09115 MNT, ROX MAX-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09115 Q0VH32 363 6.6e-33 Max-binding protein MNT OS=Xenopus laevis GN=mnt PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.38659 BP_3 1998.00 40.37 2677 91088885 XP_972389.1 2029 9.2e-225 PREDICTED: 26S protease regulatory subunit 7 [Tribolium castaneum]>gi|270012350|gb|EFA08798.1| hypothetical protein TcasGA2_TC006492 [Tribolium castaneum] 768445130 XM_011566149.1 416 0 PREDICTED: Plutella xylostella 26S protease regulatory subunit 7 (LOC105394268), mRNA K03061 PSMC2, RPT1 26S proteasome regulatory subunit T1 http://www.genome.jp/dbget-bin/www_bget?ko:K03061 P46472 1907 5.3e-212 26S protease regulatory subunit 7 OS=Xenopus laevis GN=psmc2 PE=2 SV=1 PF07724//PF00004//PF00158//PF07823//PF06068//PF05496//PF07728//PF14532//PF01695//PF00910//PF07726 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//Cyclic phosphodiesterase-like protein//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//IstB-like ATP binding protein//RNA helicase//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0030163//GO:0006355//GO:0006281 DNA recombination//protein catabolic process//regulation of transcription, DNA-templated//DNA repair GO:0009378//GO:0017111//GO:0003724//GO:0003678//GO:0003723//GO:0016887//GO:0004112//GO:0005524//GO:0008134 four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity//DNA helicase activity//RNA binding//ATPase activity//cyclic-nucleotide phosphodiesterase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0005737//GO:0009379 replication fork//transcription factor complex//cytoplasm//Holliday junction helicase complex KOG0729 26S proteasome regulatory complex, ATPase RPT1 Cluster-8309.38660 BP_3 1066.04 17.56 3218 478253025 ENN73405.1 1585 3.4e-173 hypothetical protein YQE_09967, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q15075 179 1.5e-11 Early endosome antigen 1 OS=Homo sapiens GN=EEA1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38661 BP_3 261.68 5.09 2768 642937304 XP_008198778.1 946 3.6e-99 PREDICTED: zinc finger SWIM domain-containing protein 8 [Tribolium castaneum] 194892748 XM_001977686.1 132 5.23793e-60 Drosophila erecta GG19197 (Dere\GG19197), mRNA -- -- -- -- A7E305 416 4.3e-39 Zinc finger SWIM domain-containing protein 8 OS=Bos taurus GN=ZSWIM8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38662 BP_3 2553.85 29.35 4486 91077984 XP_968658.1 1421 4.9e-154 PREDICTED: serine protease 42 [Tribolium castaneum]>gi|270002734|gb|EEZ99181.1| serine protease H2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 440 1.1e-41 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF09284//PF00089 Rhamnogalacturonan lyase B, N-terminal//Trypsin GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0016837//GO:0030246//GO:0008233//GO:0004252 carbon-oxygen lyase activity, acting on polysaccharides//carbohydrate binding//peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.38663 BP_3 1134.21 35.40 1836 728416984 AIY68330.1 1605 9.3e-176 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 775 6.7e-81 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.38665 BP_3 107.66 2.43 2424 642929061 XP_008195675.1 898 1.2e-93 PREDICTED: metastasis suppressor protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205 WH2 motif -- -- GO:0003779 actin binding -- -- -- -- Cluster-8309.38666 BP_3 107.81 1.19 4651 546680383 ERL90662.1 183 1.8e-10 hypothetical protein D910_08009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07517//PF02179//PF00816//PF04905//PF07544 SecA DEAD-like domain//BAG domain//H-NS histone family//NAB conserved region 2 (NCD2)//RNA polymerase II transcription mediator complex subunit 9 GO:0006355//GO:0045892//GO:0006357//GO:0017038 regulation of transcription, DNA-templated//negative regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//protein import GO:0051087//GO:0003677//GO:0001104//GO:0005524 chaperone binding//DNA binding//RNA polymerase II transcription cofactor activity//ATP binding GO:0016020//GO:0005622//GO:0016592//GO:0005634 membrane//intracellular//mediator complex//nucleus -- -- Cluster-8309.38668 BP_3 189.33 1.63 5903 642919151 XP_008191758.1 3900 0.0e+00 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] 821465109 XM_003759914.2 38 2.02026e-07 PREDICTED: Sarcophilus harrisii complement component 6 (C6), mRNA -- -- -- -- Q98930 2175 9.8e-243 Sortilin-related receptor (Fragment) OS=Gallus gallus GN=SORL1 PE=2 SV=1 PF04345//PF11057//PF00041//PF00057 Chorismate lyase//Cortexin of kidney//Fibronectin type III domain//Low-density lipoprotein receptor domain class A GO:0006744 ubiquinone biosynthetic process GO:0008813//GO:0005515 chorismate lyase activity//protein binding GO:0031224//GO:0005737 intrinsic component of membrane//cytoplasm KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38669 BP_3 31.91 0.58 2933 642919151 XP_008191758.1 2747 5.6e-308 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88307 1587 7.4e-175 Sortilin-related receptor OS=Mus musculus GN=Sorl1 PE=1 SV=3 PF00057//PF02077//PF03216//PF11057 Low-density lipoprotein receptor domain class A//SURF4 family//Rhabdovirus nucleoprotein//Cortexin of kidney -- -- GO:0005515 protein binding GO:0016021//GO:0031224//GO:0019013 integral component of membrane//intrinsic component of membrane//viral nucleocapsid KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38672 BP_3 39.96 0.69 3063 270002486 EEZ98933.1 2974 0.0e+00 hypothetical protein TcasGA2_TC004554 [Tribolium castaneum] 749758627 XM_011142875.1 118 3.51762e-52 PREDICTED: Harpegnathos saltator furin-like protease 2 (LOC105184226), transcript variant X4, mRNA -- -- -- -- P30432 1724 1.0e-190 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF01483//PF00757 Proprotein convertase P-domain//Furin-like cysteine rich region GO:0007169//GO:0006468//GO:0006508 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation//proteolysis GO:0004714//GO:0004252//GO:0005524 transmembrane receptor protein tyrosine kinase activity//serine-type endopeptidase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.38673 BP_3 587.43 2.23 13009 91092056 XP_970271.1 4135 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] 157125487 XM_001654304.1 70 7.26373e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 3356 0.0e+00 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF01593//PF01207//PF06574//PF01884//PF01704//PF04218//PF07992//PF00196//PF00070//PF02796//PF05946//PF05225//PF04545//PF03184//PF01180 Flavin containing amine oxidoreductase//Dihydrouridine synthase (Dus)//FAD synthetase//PcrB family//UTP--glucose-1-phosphate uridylyltransferase//CENP-B N-terminal DNA-binding domain//Pyridine nucleotide-disulphide oxidoreductase//Bacterial regulatory proteins, luxR family//Pyridine nucleotide-disulphide oxidoreductase//Helix-turn-helix domain of resolvase//Toxin-coregulated pilus subunit TcpA//helix-turn-helix, Psq domain//Sigma-70, region 4//DDE superfamily endonuclease//Dihydroorotate dehydrogenase GO:0009231//GO:0008152//GO:0006310//GO:0006771//GO:0055114//GO:0006118//GO:0006222//GO:0006352//GO:0006206//GO:0006207//GO:0009405//GO:0008033//GO:0006355 riboflavin biosynthetic process//metabolic process//DNA recombination//riboflavin metabolic process//oxidation-reduction process//obsolete electron transport//UMP biosynthetic process//DNA-templated transcription, initiation//pyrimidine nucleobase metabolic process//'de novo' pyrimidine nucleobase biosynthetic process//pathogenesis//tRNA processing//regulation of transcription, DNA-templated GO:0016491//GO:0016987//GO:0003676//GO:0070569//GO:0003700//GO:0016765//GO:0017150//GO:0004158//GO:0003677//GO:0009055//GO:0050660//GO:0000150//GO:0016627//GO:0003919//GO:0051536 oxidoreductase activity//sigma factor activity//nucleic acid binding//uridylyltransferase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring alkyl or aryl (other than methyl) groups//tRNA dihydrouridine synthase activity//dihydroorotate oxidase activity//DNA binding//electron carrier activity//flavin adenine dinucleotide binding//recombinase activity//oxidoreductase activity, acting on the CH-CH group of donors//FMN adenylyltransferase activity//iron-sulfur cluster binding GO:0005667//GO:0043230//GO:0009289//GO:0005737 transcription factor complex//extracellular organelle//pilus//cytoplasm KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.38674 BP_3 30.22 0.40 3973 642928439 XP_008193785.1 571 1.6e-55 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 542212872 XM_003439847.2 103 9.97368e-44 PREDICTED: Oreochromis niloticus ras-related protein Rab-8A-like (LOC100691063), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P35280 516 1.6e-50 Ras-related protein Rab-8A OS=Rattus norvegicus GN=Rab8a PE=1 SV=2 PF10662//PF00071//PF00025//PF08477//PF07728 Ethanolamine utilisation - propanediol utilisation//Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily) GO:0006576//GO:0007264//GO:0015031 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport GO:0005525//GO:0005524//GO:0016887 GTP binding//ATP binding//ATPase activity -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.38676 BP_3 172.45 3.74 2512 642928849 XP_008195587.1 445 4.1e-41 PREDICTED: mediator of RNA polymerase II transcription subunit 16 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15159 MED16 mediator of RNA polymerase II transcription subunit 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15159 Q16K67 223 9.3e-17 Mediator of RNA polymerase II transcription subunit 16 OS=Aedes aegypti GN=MED16 PE=3 SV=1 PF08395//PF02532 7tm Chemosensory receptor//Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979//GO:0050909 photosynthesis//sensory perception of taste -- -- GO:0009539//GO:0009523//GO:0016021//GO:0016020 photosystem II reaction center//photosystem II//integral component of membrane//membrane -- -- Cluster-8309.38677 BP_3 245.42 13.14 1192 642914847 XP_008195031.1 328 7.1e-28 PREDICTED: transmembrane protein 60 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K174 129 3.5e-06 Transmembrane protein 60 OS=Mus musculus GN=Tmem60 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38681 BP_3 168.96 4.92 1947 91076170 XP_971503.1 1431 1.5e-155 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 195 3.48977e-95 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 289 1.6e-24 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38682 BP_3 33.91 0.94 2036 642929661 XP_008195926.1 271 5.0e-21 PREDICTED: uncharacterized protein LOC103313709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0006118//GO:0055114//GO:0006570 obsolete electron transport//oxidation-reduction process//tyrosine metabolic process GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.38683 BP_3 1068.40 22.44 2587 478260541 ENN80244.1 467 1.2e-43 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911792 XM_008202523.1 93 2.34248e-38 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X2, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q12974 310 7.8e-27 Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens GN=PTP4A2 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.38684 BP_3 488.52 14.29 1939 91081621 XP_966892.1 1748 2.6e-192 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 866 2.0e-91 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF03144//PF00501 Elongation factor Tu domain 2//AMP-binding enzyme GO:0008152 metabolic process GO:0003824//GO:0005525 catalytic activity//GTP binding -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.38686 BP_3 405.74 11.70 1963 91078084 XP_972157.1 1933 9.2e-214 PREDICTED: protein neuralized isoform X1 [Tribolium castaneum]>gi|270001399|gb|EEZ97846.1| hypothetical protein TcasGA2_TC000216 [Tribolium castaneum] -- -- -- -- -- K01931 NEUR protein neuralized http://www.genome.jp/dbget-bin/www_bget?ko:K01931 Q24746 602 8.2e-61 Protein neuralized OS=Drosophila virilis GN=neur PE=3 SV=1 -- -- -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.38688 BP_3 58.79 2.65 1361 91085997 XP_972384.1 1187 2.0e-127 PREDICTED: cyclin-related protein FAM58A [Tribolium castaneum]>gi|270010183|gb|EFA06631.1| hypothetical protein TcasGA2_TC009550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4QQW5 520 1.8e-51 Cyclin-related protein FAM58A OS=Rattus norvegicus GN=Fam58a PE=2 SV=1 PF02984 Cyclin, C-terminal domain GO:0000079//GO:0006355 regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0005634 nucleus KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.38690 BP_3 77.91 1.81 2364 642930472 XP_008196416.1 262 6.4e-20 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] 407731617 JQ771526.1 224 3.21712e-111 Tetraopes tetrophthalmus Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds -- -- -- -- Q868Z9 159 2.3e-09 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF08686 PLAC (protease and lacunin) domain -- -- GO:0008233 peptidase activity -- -- -- -- Cluster-8309.38691 BP_3 40.00 3.03 928 662195082 XP_008470516.1 159 2.2e-08 PREDICTED: sodium/potassium-transporting ATPase subunit alpha-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q9YH26 149 1.3e-08 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Oreochromis mossambicus GN=atp1a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.38693 BP_3 3624.26 10.65 16690 826459797 XP_012533974.1 4761 0.0e+00 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X3 [Monomorium pharaonis] 407731599 JQ771517.1 1610 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF02714//PF13895//PF00014//PF05986//PF04545//PF08686//PF00122 Calcium-dependent channel, 7TM region, putative phosphate//Immunoglobulin domain//Kunitz/Bovine pancreatic trypsin inhibitor domain//ADAM-TS Spacer 1//Sigma-70, region 4//PLAC (protease and lacunin) domain//E1-E2 ATPase GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0000166//GO:0016987//GO:0008233//GO:0003700//GO:0046872//GO:0004222//GO:0003677//GO:0004867//GO:0005515 nucleotide binding//sigma factor activity//peptidase activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//metalloendopeptidase activity//DNA binding//serine-type endopeptidase inhibitor activity//protein binding GO:0016020//GO:0031012//GO:0005667 membrane//extracellular matrix//transcription factor complex KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.38698 BP_3 1173.94 19.34 3217 642916840 XP_008199525.1 1090 8.5e-116 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X3 [Tribolium castaneum] 170068311 XM_001868784.1 204 5.76319e-100 Culex quinquefasciatus serine/threonine-protein phosphatase 2B catalytic subunit 2, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 933 5.6e-99 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.38699 BP_3 269.89 0.71 18665 612342210 AHW99830.1 19187 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1380 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 16225 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF13499//PF13833//PF02815//PF00622//PF01365//PF00487//PF06423//PF06459//PF00520 EF-hand domain pair//EF-hand domain pair//MIR domain//SPRY domain//RIH domain//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//Ion transport protein GO:0006506//GO:0006811//GO:0006629//GO:0006874//GO:0006816//GO:0055085//GO:0070588 GPI anchor biosynthetic process//ion transport//lipid metabolic process//cellular calcium ion homeostasis//calcium ion transport//transmembrane transport//calcium ion transmembrane transport GO:0005509//GO:0005262//GO:0005219//GO:0005515//GO:0016746//GO:0005216 calcium ion binding//calcium channel activity//ryanodine-sensitive calcium-release channel activity//protein binding//transferase activity, transferring acyl groups//ion channel activity GO:0016020//GO:0005789//GO:0005622//GO:0016021 membrane//endoplasmic reticulum membrane//intracellular//integral component of membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.387 BP_3 19.00 3.11 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38700 BP_3 2142.74 40.62 2834 270004742 EFA01190.1 2041 4.0e-226 hypothetical protein TcasGA2_TC010516 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 1586 9.4e-175 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006090//GO:0071436//GO:0006814//GO:0006525//GO:0006560 pyruvate metabolic process//sodium ion export//sodium ion transport//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane KOG3097 Predicted membrane protein Cluster-8309.38701 BP_3 40.03 0.36 5710 642922300 XP_008193101.1 1696 8.1e-186 PREDICTED: LOW QUALITY PROTEIN: isovaleryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 1323 5.9e-144 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF02770//PF02270//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Transcription initiation factor IIF, beta subunit//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114//GO:0006367//GO:0006118//GO:0006366//GO:0008152 oxidation-reduction process//transcription initiation from RNA polymerase II promoter//obsolete electron transport//transcription from RNA polymerase II promoter//metabolic process GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.38702 BP_3 680.72 3.26 10360 91088831 XP_970461.1 3072 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X1 [Tribolium castaneum]>gi|270012333|gb|EFA08781.1| hypothetical protein TcasGA2_TC006471 [Tribolium castaneum] 645001221 XM_001601899.3 112 2.5959e-48 PREDICTED: Nasonia vitripennis 60S ribosomal protein L34-like (LOC100113629), mRNA K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O88813 1719 1.3e-189 Long-chain-fatty-acid--CoA ligase 5 OS=Rattus norvegicus GN=Acsl5 PE=1 SV=1 PF01434//PF02601//PF16053//PF01363//PF07168//PF05008//PF00501//PF01199 Peptidase family M41//Exonuclease VII, large subunit//Mitochondrial 28S ribosomal protein S34//FYVE zinc finger//Ureide permease//Vesicle transport v-SNARE protein N-terminus//AMP-binding enzyme//Ribosomal protein L34e GO:0006886//GO:0042254//GO:0006412//GO:0071705//GO:0008152//GO:0006308//GO:0006508 intracellular protein transport//ribosome biogenesis//translation//nitrogen compound transport//metabolic process//DNA catabolic process//proteolysis GO:0005524//GO:0004222//GO:0003735//GO:0008855//GO:0003824//GO:0046872 ATP binding//metalloendopeptidase activity//structural constituent of ribosome//exodeoxyribonuclease VII activity//catalytic activity//metal ion binding GO:0005739//GO:0005622//GO:0009318//GO:0005840//GO:0016020 mitochondrion//intracellular//exodeoxyribonuclease VII complex//ribosome//membrane KOG1256 Long-chain acyl-CoA synthetases (AMP-forming) Cluster-8309.38703 BP_3 841.00 5.49 7676 270009277 EFA05725.1 471 1.2e-43 homolog of RecQ [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96923 154 2.9e-08 Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum GN=gnrA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38704 BP_3 701.43 17.61 2212 642933080 XP_008197251.1 1014 3.8e-107 PREDICTED: ribosome biogenesis regulatory protein homolog [Tribolium castaneum] 795027340 XM_012006858.1 35 3.4888e-06 PREDICTED: Vollenhovia emeryi ribosome biogenesis regulatory protein homolog (LOC105558919), mRNA K14852 RRS1 regulator of ribosome biosynthesis http://www.genome.jp/dbget-bin/www_bget?ko:K14852 Q2KIH4 604 5.4e-61 Ribosome biogenesis regulatory protein homolog OS=Bos taurus GN=RRS1 PE=2 SV=1 PF04939 Ribosome biogenesis regulatory protein (RRS1) GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1765 Regulator of ribosome synthesis Cluster-8309.38707 BP_3 767.92 8.51 4641 357625687 EHJ76049.1 1321 2.0e-142 dimethyladenosine transferase [Danaus plexippus] 505801989 XM_004608470.1 131 3.17545e-59 PREDICTED: Sorex araneus DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) (DIMT1), mRNA K14191 DIM1 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14191 Q9VAQ5 1179 2.4e-127 Probable dimethyladenosine transferase OS=Drosophila melanogaster GN=CG11837 PE=2 SV=1 PF05401//PF01209//PF05958//PF09445//PF08123//PF01135//PF05175//PF16711//PF02390//PF08241 Nodulation protein S (NodS)//ubiE/COQ5 methyltransferase family//tRNA (Uracil-5-)-methyltransferase//RNA cap guanine-N2 methyltransferase//Histone methylation protein DOT1//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Actin-binding domain of plant-specific actin-binding protein//Putative methyltransferase//Methyltransferase domain GO:0009452//GO:0008152//GO:0001510//GO:0006400//GO:0046500//GO:0009877//GO:0009451//GO:0006479//GO:0006464//GO:0009312//GO:0006554//GO:0006396//GO:0008033 7-methylguanosine RNA capping//metabolic process//RNA methylation//tRNA modification//S-adenosylmethionine metabolic process//nodulation//RNA modification//protein methylation//cellular protein modification process//oligosaccharide biosynthetic process//lysine catabolic process//RNA processing//tRNA processing GO:0008173//GO:0008757//GO:0018024//GO:0004719//GO:0008176//GO:0003779//GO:0008168 RNA methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//histone-lysine N-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//actin binding//methyltransferase activity -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.38709 BP_3 1041.98 20.47 2745 91078042 XP_966587.1 679 3.3e-68 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 419 1.9e-39 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38710 BP_3 6.29 0.56 831 270002313 EEZ98760.1 331 2.2e-28 hypothetical protein TcasGA2_TC001324 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 247 5.1e-20 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 PF01791 DeoC/LacD family aldolase -- -- GO:0016829 lyase activity -- -- -- -- Cluster-8309.38711 BP_3 82.02 1.81 2476 642916856 XP_968783.3 169 4.1e-09 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38712 BP_3 3762.52 31.15 6113 642916856 XP_968783.3 1187 9.1e-127 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] 242023932 XM_002432340.1 66 5.69595e-23 Pediculus humanus corporis proteasome subunit beta type, putative, mRNA K02732 PSMB1 20S proteasome subunit beta 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02732 P40304 767 1.9e-79 Proteasome subunit beta type-1 OS=Drosophila melanogaster GN=Prosbeta6 PE=2 SV=2 PF00227//PF13673//PF00096//PF13413//PF12844//PF01381//PF04988//PF13912 Proteasome subunit//Acetyltransferase (GNAT) domain//Zinc finger, C2H2 type//Helix-turn-helix domain//Helix-turn-helix domain//Helix-turn-helix//A-kinase anchoring protein 95 (AKAP95)//C2H2-type zinc finger GO:0051603//GO:0042967 proteolysis involved in cellular protein catabolic process//acyl-carrier-protein biosynthetic process GO:0043565//GO:0004298//GO:0046872//GO:0003677//GO:0008080 sequence-specific DNA binding//threonine-type endopeptidase activity//metal ion binding//DNA binding//N-acetyltransferase activity GO:0005839//GO:0005634 proteasome core complex//nucleus KOG0179 20S proteasome, regulatory subunit beta type PSMB1/PRE7 Cluster-8309.38713 BP_3 24.86 10.74 402 546676039 ERL87122.1 159 9.5e-09 hypothetical protein D910_04522 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38714 BP_3 427.39 3.90 5570 478252696 ENN73092.1 1663 5.3e-182 hypothetical protein YQE_10296, partial [Dendroctonus ponderosae] -- -- -- -- -- K04681 RBL1 retinoblastoma-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04681 Q64701 1034 1.9e-110 Retinoblastoma-like protein 1 OS=Mus musculus GN=Rbl1 PE=1 SV=3 PF01858//PF01857 Retinoblastoma-associated protein A domain//Retinoblastoma-associated protein B domain GO:0051726 regulation of cell cycle -- -- GO:0005634 nucleus KOG1010 Rb (Retinoblastoma tumor suppressor)-related protein Cluster-8309.38716 BP_3 80.00 2.23 2022 557781264 XP_005190251.1 148 9.0e-07 PREDICTED: uncharacterized protein LOC101898742, partial [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.38717 BP_3 50.17 2.74 1173 91090842 XP_972243.1 1533 1.3e-167 PREDICTED: large neutral amino acids transporter small subunit 1 [Tribolium castaneum]>gi|270013246|gb|EFA09694.1| hypothetical protein TcasGA2_TC011826 [Tribolium castaneum] 642935933 XM_967150.2 392 0 PREDICTED: Tribolium castaneum large neutral amino acids transporter small subunit 1 (LOC660956), mRNA K03450 SLC7A solute carrier family 7 (L-type amino acid transporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K03450 Q8BGK6 951 1.7e-101 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0006810//GO:0006865//GO:0003333//GO:0055085 transport//amino acid transport//amino acid transmembrane transport//transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1287 Amino acid transporters Cluster-8309.38718 BP_3 146.62 2.68 2924 264667363 ACY71267.1 534 2.3e-51 ribosomal protein S24 [Chrysomela tremula] 642917806 XM_962484.3 213 5.19546e-105 PREDICTED: Tribolium castaneum 40S ribosomal protein S24 (LOC655928), mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 Q962Q6 511 4.4e-50 40S ribosomal protein S24 OS=Spodoptera frugiperda GN=RpS24 PE=2 SV=1 PF01282 Ribosomal protein S24e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3424 40S ribosomal protein S24 Cluster-8309.38721 BP_3 8190.48 129.72 3335 727098932 AIY54299.1 1395 3.8e-151 glyceraldehyde 3-phosphate dehydrogenase [Colaphellus bowringi] 195457061 XM_002075373.1 330 5.41337e-170 Drosophila willistoni GK17768 (Dwil\GK17768), mRNA K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q4U3L0 1314 3.8e-143 Glyceraldehyde-3-phosphate dehydrogenase OS=Glossina morsitans morsitans GN=Gapdh PE=2 SV=1 PF02800//PF00107//PF02826//PF00044 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Zinc-binding dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016620//GO:0051287 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.38722 BP_3 166.73 3.87 2368 642923825 XP_008193895.1 1869 2.9e-206 PREDICTED: pseudouridine-metabolizing bifunctional protein C1861.05 [Tribolium castaneum] -- -- -- -- -- K16330 K16330 pseudouridine-5'-phosphate glycosidase / pseudouridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K16330 A7GCK7 778 3.9e-81 Pseudouridine-5'-phosphate glycosidase OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) GN=psuG PE=3 SV=1 PF05275//PF04227 Copper resistance protein B precursor (CopB)//Indigoidine synthase A like protein GO:0006878 cellular copper ion homeostasis GO:0016798//GO:0005507 hydrolase activity, acting on glycosyl bonds//copper ion binding GO:0009279 cell outer membrane KOG3009 Predicted carbohydrate kinase, contains PfkB domain Cluster-8309.38723 BP_3 1782.77 65.93 1595 270013857 EFA10305.1 878 1.6e-91 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 412 7.2e-39 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38724 BP_3 24.80 1.37 1166 642922790 XP_008193326.1 891 3.6e-93 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P19823 340 1.2e-30 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens GN=ITIH2 PE=1 SV=2 PF04227 Indigoidine synthase A like protein -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds -- -- -- -- Cluster-8309.38725 BP_3 77.30 0.42 9108 642911349 XP_008199384.1 6683 0.0e+00 PREDICTED: uncharacterized protein LOC659886 isoform X1 [Tribolium castaneum] 642911358 XM_008201167.1 137 2.88877e-62 PREDICTED: Tribolium castaneum uncharacterized LOC659886 (LOC659886), transcript variant X6, mRNA -- -- -- -- B6RSP1 355 1.7e-31 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38727 BP_3 150.76 2.07 3810 478263044 ENN81444.1 2150 1.2e-238 hypothetical protein YQE_02137, partial [Dendroctonus ponderosae] -- -- -- -- -- K10902 RECQL5 ATP-dependent DNA helicase Q5 http://www.genome.jp/dbget-bin/www_bget?ko:K10902 Q8VID5 1002 6.6e-107 ATP-dependent DNA helicase Q5 OS=Mus musculus GN=Recql5 PE=2 SV=1 PF08236//PF00391//PF00270 SRI (Set2 Rpb1 interacting) domain//PEP-utilising enzyme, mobile domain//DEAD/DEAH box helicase GO:0034968//GO:0016310//GO:0006554//GO:0006355//GO:0006479 histone lysine methylation//phosphorylation//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005524//GO:0018024//GO:0016772//GO:0003676 ATP binding//histone-lysine N-methyltransferase activity//transferase activity, transferring phosphorus-containing groups//nucleic acid binding GO:0005694 chromosome KOG0351 ATP-dependent DNA helicase Cluster-8309.38730 BP_3 141.24 3.52 2228 189240952 XP_971597.2 1948 1.9e-215 PREDICTED: methionine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q9VFL5 1426 2.6e-156 Methionine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-met PE=2 SV=2 PF09334//PF00133//PF08264 tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity -- -- KOG0436 Methionyl-tRNA synthetase Cluster-8309.38731 BP_3 91.00 7.49 877 189234232 XP_973217.2 444 1.9e-41 PREDICTED: serine/threonine-protein kinase Warts [Tribolium castaneum]>gi|270002603|gb|EEZ99050.1| hypothetical protein TcasGA2_TC004924 [Tribolium castaneum] 642912553 XM_968124.3 117 3.5256e-52 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Warts (LOC661996), mRNA K08791 LATS1_2, Wts serine/threonine-protein kinase LATS1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08791 -- -- -- -- -- -- -- -- GO:0016301 kinase activity -- -- -- -- Cluster-8309.38733 BP_3 886.53 7.37 6093 189240296 XP_973610.2 1369 7.1e-148 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 Q9R229 430 2.2e-40 Bone morphogenetic protein 10 OS=Mus musculus GN=Bmp10 PE=2 SV=2 PF00019//PF09172//PF01347 Transforming growth factor beta like domain//Domain of unknown function (DUF1943)//Lipoprotein amino terminal region GO:0006869//GO:0008283//GO:0007165//GO:0040007 lipid transport//cell proliferation//signal transduction//growth GO:0005319//GO:0008083 lipid transporter activity//growth factor activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.38736 BP_3 26.33 0.33 4087 546682397 ERL92339.1 422 3.1e-38 hypothetical protein D910_09656 [Dendroctonus ponderosae] 195384494 XM_002050917.1 45 1.79174e-11 Drosophila virilis GJ22432 (Dvir\GJ22432), mRNA -- -- -- -- Q6P3Z3 295 6.8e-25 THAP domain-containing protein 4 OS=Mus musculus GN=Thap4 PE=2 SV=1 PF03271//PF05361//PF06070 EB1-like C-terminal motif//PKC-activated protein phosphatase-1 inhibitor//Herpesvirus large structural phosphoprotein UL32 GO:0042325 regulation of phosphorylation GO:0005198//GO:0008017 structural molecule activity//microtubule binding GO:0005737//GO:0045298 cytoplasm//tubulin complex KOG3000 Microtubule-binding protein involved in cell cycle control Cluster-8309.38737 BP_3 251.23 5.81 2376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38738 BP_3 782.41 18.67 2312 91084077 XP_968062.1 1175 8.5e-126 PREDICTED: protein odr-4 homolog [Tribolium castaneum]>gi|270008008|gb|EFA04456.1| hypothetical protein TcasGA2_TC014760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWX8 374 2.6e-34 Protein odr-4 homolog OS=Homo sapiens GN=ODR4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38739 BP_3 446.00 31.79 968 478263000 ENN81406.1 667 2.9e-67 hypothetical protein YQE_02222, partial [Dendroctonus ponderosae]>gi|546674219|gb|ERL85652.1| hypothetical protein D910_03069 [Dendroctonus ponderosae] -- -- -- -- -- K03937 NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03937 O43181 428 6.1e-41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens GN=NDUFS4 PE=1 SV=1 PF04800 ETC complex I subunit conserved region GO:0022900 electron transport chain GO:0016651 oxidoreductase activity, acting on NAD(P)H -- -- KOG3389 NADH:ubiquinone oxidoreductase, NDUFS4/18 kDa subunit Cluster-8309.38741 BP_3 775.00 16.16 2603 91076104 XP_968648.1 3116 0.0e+00 PREDICTED: 1,4-alpha-glucan-branching enzyme [Tribolium castaneum]>gi|270014582|gb|EFA11030.1| hypothetical protein TcasGA2_TC004619 [Tribolium castaneum] 194754710 XM_001959602.1 211 5.97795e-104 Drosophila ananassae GF11944 (Dana\GF11944), mRNA K00700 glgB 1,4-alpha-glucan branching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K00700 Q9D6Y9 2296 4.0e-257 1,4-alpha-glucan-branching enzyme OS=Mus musculus GN=Gbe1 PE=2 SV=1 PF02806//PF02922//PF00128 Alpha amylase, C-terminal all-beta domain//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//Alpha amylase, catalytic domain GO:0005985//GO:0005982//GO:0005975//GO:0005978 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process//glycogen biosynthetic process GO:0004553//GO:0003824//GO:0003844//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//catalytic activity//1,4-alpha-glucan branching enzyme activity//cation binding -- -- KOG0470 1,4-alpha-glucan branching enzyme/starch branching enzyme II Cluster-8309.38742 BP_3 732.00 8.48 4454 91091526 XP_970162.1 4481 0.0e+00 PREDICTED: tolloid-like protein 1 [Tribolium castaneum]>gi|270001271|gb|EEZ97718.1| hypothetical protein TcasGA2_TC011197 [Tribolium castaneum] 572267902 XM_006611951.1 168 8.23408e-80 PREDICTED: Apis dorsata tolloid-like protein 2-like (LOC102680377), transcript variant X2, mRNA K13046 tok tolkin http://www.genome.jp/dbget-bin/www_bget?ko:K13046 Q9DER7 2700 9.8e-304 Tolloid-like protein 1 OS=Gallus gallus GN=TLL1 PE=2 SV=1 PF00413//PF01400//PF07645//PF00008 Matrixin//Astacin (Peptidase family M12A)//Calcium-binding EGF domain//EGF-like domain GO:0006508 proteolysis GO:0005515//GO:0004222//GO:0005509//GO:0008270 protein binding//metalloendopeptidase activity//calcium ion binding//zinc ion binding GO:0031012 extracellular matrix KOG3714 Meprin A metalloprotease Cluster-8309.38743 BP_3 3091.00 68.21 2476 642914282 XP_008201620.1 841 4.9e-87 PREDICTED: uncharacterized protein LOC103315234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38744 BP_3 857.00 11.30 3946 91081613 XP_966546.1 1637 3.9e-179 PREDICTED: protein goliath-like [Tribolium castaneum] 768414717 XM_011549573.1 132 7.49645e-60 PREDICTED: Plutella xylostella protein goliath (LOC105380077), mRNA -- -- -- -- Q06003 751 8.7e-78 Protein goliath OS=Drosophila melanogaster GN=gol PE=2 SV=3 PF13639//PF01165//PF12861//PF00335//PF06667//PF14634//PF17123//PF12678//PF00097 Ring finger domain//Ribosomal protein S21//Anaphase-promoting complex subunit 11 RING-H2 finger//Tetraspanin family//Phage shock protein B//zinc-RING finger domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0009271//GO:0016567//GO:0006412//GO:0006355//GO:0042254 phage shock//protein ubiquitination//translation//regulation of transcription, DNA-templated//ribosome biogenesis GO:0005515//GO:0004842//GO:0008270//GO:0003735//GO:0046872 protein binding//ubiquitin-protein transferase activity//zinc ion binding//structural constituent of ribosome//metal ion binding GO:0016021//GO:0005680//GO:0005840 integral component of membrane//anaphase-promoting complex//ribosome KOG4628 Predicted E3 ubiquitin ligase Cluster-8309.38746 BP_3 30.00 4.21 635 546685214 ERL94741.1 268 3.5e-21 hypothetical protein D910_12015 [Dendroctonus ponderosae] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 -- -- -- -- PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38747 BP_3 59.92 0.39 7757 91084663 XP_967750.1 2228 2.2e-247 PREDICTED: ubiquitin carboxyl-terminal hydrolase 4 isoform X1 [Tribolium castaneum]>gi|270008628|gb|EFA05076.1| hypothetical protein TcasGA2_TC015173 [Tribolium castaneum] 698430595 XM_009698856.1 46 9.49066e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K11833 USP2_21 ubiquitin carboxyl-terminal hydrolase 2/21 http://www.genome.jp/dbget-bin/www_bget?ko:K11833 O57429 1001 1.8e-106 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF00443//PF04857//PF05427//PF12422//PF01119//PF15957 Ubiquitin carboxyl-terminal hydrolase//CAF1 family ribonuclease//Acidic fibroblast growth factor binding (FIBP)//Condensin II non structural maintenance of chromosomes subunit//DNA mismatch repair protein, C-terminal domain//Commissureless GO:0016579//GO:0006298//GO:0007411 protein deubiquitination//mismatch repair//axon guidance GO:0030983//GO:0017134//GO:0016787//GO:0005524//GO:0036459 mismatched DNA binding//fibroblast growth factor binding//hydrolase activity//ATP binding//ubiquitinyl hydrolase activity GO:0005634 nucleus KOG1979 DNA mismatch repair protein - MLH1 family Cluster-8309.38748 BP_3 407.79 9.60 2339 189240983 XP_966935.2 1607 6.9e-176 PREDICTED: DDB1- and CUL4-associated factor 10 homolog [Tribolium castaneum]>gi|270012997|gb|EFA09445.1| hypothetical protein TcasGA2_TC010660 [Tribolium castaneum] -- -- -- -- -- K11802 WDR32 WD repeat-containing protein 32 http://www.genome.jp/dbget-bin/www_bget?ko:K11802 Q9VAT2 713 1.3e-73 DDB1- and CUL4-associated factor 10 homolog OS=Drosophila melanogaster GN=CG1523 PE=1 SV=1 PF00400//PF08447 WD domain, G-beta repeat//PAS fold -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.38750 BP_3 149.17 7.12 1301 642933239 XP_008197324.1 539 2.7e-52 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38752 BP_3 758.00 32.79 1406 332372740 AEE61512.1 892 3.4e-93 unknown [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q7PWV1 372 2.7e-34 Aquaporin AQPAn.G OS=Anopheles gambiae GN=AGAP008842 PE=3 SV=4 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.38753 BP_3 1064.31 8.64 6232 589060792 AHK26789.1 2872 0.0e+00 pyruvate carboxylase, partial [Epicauta chinensis] 817070062 XM_012401613.1 189 2.44717e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 2262 8.5e-253 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF00682//PF05896//PF02655//PF07478//PF02786 HMGL-like//Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//ATP-grasp domain//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain GO:0006814//GO:0006118//GO:0055114//GO:0009252//GO:0046436 sodium ion transport//obsolete electron transport//oxidation-reduction process//peptidoglycan biosynthetic process//D-alanine metabolic process GO:0008716//GO:0016655//GO:0046872//GO:0005524//GO:0003824 D-alanine-D-alanine ligase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//metal ion binding//ATP binding//catalytic activity -- -- KOG0369 Pyruvate carboxylase Cluster-8309.38755 BP_3 1070.68 10.18 5360 270010132 EFA06580.1 1966 3.7e-217 hypothetical protein TcasGA2_TC009492 [Tribolium castaneum] 795059302 XM_012017418.1 258 9.24492e-130 PREDICTED: Vollenhovia emeryi F-box/LRR-repeat protein 14 (LOC105564772), mRNA K10280 FBXL14 F-box and leucine-rich repeat protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K10280 Q8N1E6 1336 1.7e-145 F-box/LRR-repeat protein 14 OS=Homo sapiens GN=FBXL14 PE=1 SV=1 PF13516//PF13855//PF12937//PF00560//PF04091//PF00646//PF01529 Leucine Rich repeat//Leucine rich repeat//F-box-like//Leucine Rich Repeat//Exocyst complex subunit Sec15-like//F-box domain//DHHC palmitoyltransferase GO:0006904 vesicle docking involved in exocytosis GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0000145 exocyst KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.38757 BP_3 599.00 41.47 988 91094879 XP_972904.1 607 2.6e-60 PREDICTED: transmembrane protein 256 homolog [Tribolium castaneum]>gi|270006585|gb|EFA03033.1| hypothetical protein TcasGA2_TC010458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4K526 304 1.5e-26 Transmembrane protein 256 homolog OS=Bufo gargarizans PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3472 Predicted small membrane protein Cluster-8309.38760 BP_3 100.59 105.15 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08485 Polysaccharide biosynthesis protein C-terminal GO:0009225//GO:0009103//GO:0006012//GO:0009117 nucleotide-sugar metabolic process//lipopolysaccharide biosynthetic process//galactose metabolic process//nucleotide metabolic process GO:0003978 UDP-glucose 4-epimerase activity -- -- -- -- Cluster-8309.38762 BP_3 29.98 0.85 1992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38766 BP_3 1320.65 24.14 2929 642936475 XP_008198451.1 2697 3.5e-302 PREDICTED: LOW QUALITY PROTEIN: G protein-coupled receptor kinase 2 [Tribolium castaneum] 749773827 XM_011143956.1 351 0 PREDICTED: Harpegnathos saltator G protein-coupled receptor kinase 2 (LOC105184862), mRNA K08291 GRK4_5_6 G protein-coupled receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08291 P32866 1848 4.0e-205 G protein-coupled receptor kinase 2 OS=Drosophila melanogaster GN=Gprk2 PE=1 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0986 G protein-coupled receptor kinase Cluster-8309.38767 BP_3 14.65 0.35 2307 189234632 XP_001815875.1 989 3.1e-104 PREDICTED: uncharacterized protein LOC100141793 [Tribolium castaneum]>gi|270002124|gb|EEZ98571.1| hypothetical protein TcasGA2_TC001083 [Tribolium castaneum] 645023008 XM_003425366.2 61 1.28205e-20 PREDICTED: Nasonia vitripennis uncharacterized LOC100678221 (LOC100678221), transcript variant X13, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38768 BP_3 37.37 0.36 5352 91090858 XP_967143.1 1197 5.5e-128 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] 688710729 LL320824.1 36 2.36794e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0001563 K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 898 1.1e-94 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF02562//PF04851//PF06733//PF00580//PF01580//PF00191//PF00270 PhoH-like protein//Type III restriction enzyme, res subunit//DEAD_2//UvrD/REP helicase N-terminal domain//FtsK/SpoIIIE family//Annexin//DEAD/DEAH box helicase -- -- GO:0005509//GO:0000166//GO:0004003//GO:0003676//GO:0005544//GO:0005524//GO:0016787//GO:0003677 calcium ion binding//nucleotide binding//ATP-dependent DNA helicase activity//nucleic acid binding//calcium-dependent phospholipid binding//ATP binding//hydrolase activity//DNA binding GO:0005657 replication fork KOG0819 Annexin Cluster-8309.38769 BP_3 595.96 12.02 2681 752439505 XP_011215366.1 513 5.7e-49 PREDICTED: zinc finger protein 345-like isoform X3 [Ailuropoda melanoleuca] -- -- -- -- -- -- -- -- -- Q6ZMW2 488 1.9e-47 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00130//PF00096//PF02072//PF10503//PF13465//PF05191//PF16622//PF02776//PF13912 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Prepro-orexin//Esterase PHB depolymerase//Zinc-finger double domain//Adenylate kinase, active site lid//zinc-finger C2H2-type//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//C2H2-type zinc finger GO:0007218//GO:0035556//GO:0007631//GO:0006144//GO:0046034 neuropeptide signaling pathway//intracellular signal transduction//feeding behavior//purine nucleobase metabolic process//ATP metabolic process GO:0030976//GO:0004017//GO:0046872 thiamine pyrophosphate binding//adenylate kinase activity//metal ion binding GO:0005576 extracellular region -- -- Cluster-8309.38770 BP_3 4424.96 283.90 1043 557767939 XP_005183655.1 515 1.3e-49 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Musca domestica] 195569934 XM_002102928.1 195 1.8422e-95 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 P47815 390 1.7e-36 Eukaryotic translation initiation factor 1A OS=Triticum aestivum PE=1 SV=2 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.38771 BP_3 649.53 12.91 2716 546676927 ERL87851.1 1793 2.2e-197 hypothetical protein D910_05239 [Dendroctonus ponderosae] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 728 2.8e-75 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.38772 BP_3 65.06 1.14 3035 642911716 XP_008200712.1 625 6.6e-62 PREDICTED: uncharacterized protein LOC103314994 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z5L2 171 1.2e-10 Coiled-coil domain-containing protein R3HCC1L OS=Homo sapiens GN=R3HCC1L PE=1 SV=2 PF08675//PF14138 RNA binding domain//Cytochrome c oxidase assembly protein COX16 GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0004535//GO:0046872 RNA binding//poly(A)-specific ribonuclease activity//metal ion binding GO:0005634//GO:0031966//GO:0005737 nucleus//mitochondrial membrane//cytoplasm -- -- Cluster-8309.38773 BP_3 187.65 4.55 2281 91079828 XP_970042.1 661 3.3e-66 PREDICTED: aprataxin [Tribolium castaneum]>gi|642918234|ref|XP_008191423.1| PREDICTED: aprataxin [Tribolium castaneum]>gi|270004538|gb|EFA00986.1| hypothetical protein TcasGA2_TC003899 [Tribolium castaneum] -- -- -- -- -- K10863 APTX aprataxin http://www.genome.jp/dbget-bin/www_bget?ko:K10863 P61799 437 1.3e-41 Aprataxin OS=Danio rerio GN=aptx PE=2 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG0562 Predicted hydrolase (HIT family) Cluster-8309.38775 BP_3 74.07 0.57 6558 91089043 XP_969794.1 4688 0.0e+00 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] 657579724 XM_008295570.1 270 2.4159e-136 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 3142 0.0e+00 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF02985//PF00400//PF06384 HEAT repeat//WD domain, G-beta repeat//Beta-catenin-interacting protein ICAT -- -- GO:0005515//GO:0008013 protein binding//beta-catenin binding GO:0016342 catenin complex KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.38776 BP_3 199.71 14.47 957 91090452 XP_967359.1 994 3.4e-105 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|642935319|ref|XP_008197966.1| PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013849|gb|EFA10297.1| hypothetical protein TcasGA2_TC012512 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q55EH8 413 3.3e-39 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF00931//PF03193//PF00005//PF01926//PF00006//PF13304//PF01637 NB-ARC domain//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//ATP synthase alpha/beta family, nucleotide-binding domain//AAA domain, putative AbiEii toxin, Type IV TA system//Archaeal ATPase GO:0006810//GO:0006200 transport//obsolete ATP catabolic process GO:0042626//GO:0005525//GO:0016887//GO:0043531//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//ADP binding//GTPase activity//ATP binding GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.38777 BP_3 874.63 4.80 9080 478260541 ENN80244.1 792 8.6e-81 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 1.80838e-29 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q9TSM6 517 2.7e-50 Protein tyrosine phosphatase type IVA 1 OS=Macaca fascicularis GN=PTP4A1 PE=1 SV=1 PF01686//PF00782//PF15750//PF00102 Adenovirus penton base protein//Dual specificity phosphatase, catalytic domain//Ubiquitin-binding zinc-finger//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725//GO:0005198//GO:0043130 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//structural molecule activity//ubiquitin binding -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.38778 BP_3 1716.58 29.94 3055 332375620 AEE62951.1 1020 1.1e-107 unknown [Dendroctonus ponderosae]>gi|546680023|gb|ERL90385.1| hypothetical protein D910_07734 [Dendroctonus ponderosae] 241989293 AK336271.1 277 1.4371e-140 Triticum aestivum cDNA, clone: SET3_K11, cultivar: Chinese Spring K01495 GCH1, folE GTP cyclohydrolase I http://www.genome.jp/dbget-bin/www_bget?ko:K01495 P48596 694 2.7e-71 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 PF02330//PF14489//PF15088 Mitochondrial glycoprotein//QueF-like protein//NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial GO:0008616 queuosine biosynthetic process GO:0033739 preQ1 synthase activity GO:0005759//GO:0005747//GO:0005739 mitochondrial matrix//mitochondrial respiratory chain complex I//mitochondrion KOG2698 GTP cyclohydrolase I Cluster-8309.38780 BP_3 1449.52 5.49 13025 642924614 XP_008194364.1 1950 6.5e-215 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 D3ZGB1 701 1.8e-71 Nuclear factor of activated T-cells 5 OS=Rattus norvegicus GN=Nfat5 PE=1 SV=1 PF00554//PF01833//PF05933//PF12529//PF00891 Rel homology DNA-binding domain//IPT/TIG domain//Fungal ATP synthase protein 8 (A6L)//Xylosyltransferase C terminal//O-methyltransferase GO:0006024//GO:0015992//GO:0030206//GO:0006355//GO:0015986 glycosaminoglycan biosynthetic process//proton transport//chondroitin sulfate biosynthetic process//regulation of transcription, DNA-templated//ATP synthesis coupled proton transport GO:0005515//GO:0003677//GO:0008171//GO:0003700//GO:0030158//GO:0015078 protein binding//DNA binding//O-methyltransferase activity//transcription factor activity, sequence-specific DNA binding//protein xylosyltransferase activity//hydrogen ion transmembrane transporter activity GO:0005667//GO:0000276 transcription factor complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.38782 BP_3 239.78 3.56 3538 478250378 ENN70873.1 937 5.1e-98 hypothetical protein YQE_12278, partial [Dendroctonus ponderosae]>gi|546672870|gb|ERL84593.1| hypothetical protein D910_02021 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q495M3 402 2.3e-37 Proton-coupled amino acid transporter 2 OS=Homo sapiens GN=SLC36A2 PE=1 SV=1 PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane KOG1304 Amino acid transporters Cluster-8309.38783 BP_3 46.00 2.32 1248 645041441 XP_008207913.1 895 1.3e-93 PREDICTED: uncharacterized protein LOC100113970 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38785 BP_3 206.73 1.29 8037 801382909 XP_012054587.1 214 8.0e-14 PREDICTED: ATP synthase lipid-binding protein, mitochondrial isoform X1 [Atta cephalotes] 6560654 AF117583.1 108 3.36635e-46 AF117583 Manduca sexta clone pMsmaC26 ATP synthase subunit c mRNA, complete cds K02128 ATPeF0C, ATP5G, ATP9 F-type H+-transporting ATPase subunit c http://www.genome.jp/dbget-bin/www_bget?ko:K02128 Q06055 205 3.6e-14 ATP synthase F(0) complex subunit C2, mitochondrial OS=Homo sapiens GN=ATP5G2 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.38786 BP_3 139.98 0.90 7769 478260669 ENN80366.1 2509 5.9e-280 hypothetical protein YQE_03225, partial [Dendroctonus ponderosae] 698430595 XM_009698856.1 46 9.50541e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K08734 MLH1 DNA mismatch repair protein MLH1 http://www.genome.jp/dbget-bin/www_bget?ko:K08734 P40692 1843 4.1e-204 DNA mismatch repair protein Mlh1 OS=Homo sapiens GN=MLH1 PE=1 SV=1 PF15957//PF01119//PF12422//PF05427//PF00443 Commissureless//DNA mismatch repair protein, C-terminal domain//Condensin II non structural maintenance of chromosomes subunit//Acidic fibroblast growth factor binding (FIBP)//Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0006298//GO:0007411 protein deubiquitination//mismatch repair//axon guidance GO:0030983//GO:0017134//GO:0036459//GO:0005524 mismatched DNA binding//fibroblast growth factor binding//ubiquitinyl hydrolase activity//ATP binding GO:0005634 nucleus KOG1979 DNA mismatch repair protein - MLH1 family Cluster-8309.38789 BP_3 38.35 0.88 2391 546681329 ERL91443.1 1890 1.1e-208 hypothetical protein D910_08773 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 284 7.5e-24 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 PF00856//PF01155 SET domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0016151//GO:0005515 nickel cation binding//protein binding -- -- -- -- Cluster-8309.3879 BP_3 14.58 0.40 2045 642936663 XP_008198528.1 410 3.8e-37 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10859 ALKBH2 alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10859 Q6P6J4 310 6.2e-27 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 OS=Mus musculus GN=Alkbh2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38790 BP_3 333.65 7.75 2366 852803594 XP_012890580.1 543 1.7e-52 PREDICTED: zinc finger protein 585A-like [Dipodomys ordii] -- -- -- -- -- -- -- -- -- P35789 516 9.3e-51 Zinc finger protein 93 OS=Homo sapiens GN=ZNF93 PE=2 SV=4 PF05151//PF13465//PF00096//PF13912//PF05485//PF16622//PF07776 Photosystem II reaction centre M protein (PsbM)//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//THAP domain//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0019684//GO:0015979 photosynthesis, light reaction//photosynthesis GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0009523//GO:0005634//GO:0016021 photosystem II//nucleus//integral component of membrane -- -- Cluster-8309.38792 BP_3 936.12 30.81 1756 478256018 ENN76217.1 1979 3.8e-219 hypothetical protein YQE_07184, partial [Dendroctonus ponderosae] 158295753 XM_001688807.1 230 1.09824e-114 Anopheles gambiae str. PEST AGAP006366-PD (AgaP_AGAP006366) mRNA, complete cds K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q6P6Z8 1493 3.5e-164 2-oxoglutarate dehydrogenase, mitochondrial OS=Xenopus laevis GN=ogdh PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.38795 BP_3 1460.31 24.01 3223 189241130 XP_973380.2 2116 9.1e-235 PREDICTED: melanotransferrin [Tribolium castaneum]>gi|270013329|gb|EFA09777.1| hypothetical protein TcasGA2_TC011919 [Tribolium castaneum] -- -- -- -- -- K06569 MFI2 melanoma-associated antigen p97 http://www.genome.jp/dbget-bin/www_bget?ko:K06569 Q9R0R1 445 2.2e-42 Melanotransferrin OS=Mus musculus GN=Mfi2 PE=2 SV=1 PF01414//PF00172 Delta serrate ligand//Fungal Zn(2)-Cys(6) binuclear cluster domain GO:0007154//GO:0006355//GO:0044699 cell communication//regulation of transcription, DNA-templated//single-organism process GO:0008270//GO:0000981 zinc ion binding//RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.38796 BP_3 728.00 18.52 2186 332372654 AEE61469.1 2912 0.0e+00 unknown [Dendroctonus ponderosae]>gi|546681887|gb|ERL91896.1| hypothetical protein D910_09219 [Dendroctonus ponderosae] -- -- -- -- -- K00311 ETFDH electron-transferring-flavoprotein dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00311 Q921G7 2327 8.6e-261 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Mus musculus GN=Etfdh PE=1 SV=1 PF00070//PF12831//PF07992//PF05834//PF01266//PF01494//PF05187 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//FAD binding domain//Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0071949//GO:0004174//GO:0016705//GO:0016491 FAD binding//electron-transferring-flavoprotein dehydrogenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- KOG2415 Electron transfer flavoprotein ubiquinone oxidoreductase Cluster-8309.38797 BP_3 329.59 10.77 1767 642939230 XP_008194770.1 356 6.0e-31 PREDICTED: uncharacterized protein LOC656988 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38798 BP_3 17.56 40.01 291 478253273 ENN73644.1 200 1.2e-13 hypothetical protein YQE_09890, partial [Dendroctonus ponderosae]>gi|546676325|gb|ERL87352.1| hypothetical protein D910_04747 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38799 BP_3 7039.03 86.54 4212 642913620 XP_008201091.1 2554 1.9e-285 PREDICTED: moesin/ezrin/radixin homolog 1 isoform X2 [Tribolium castaneum] 347964053 XM_003436981.1 591 0 Anopheles gambiae str. PEST AGAP000562-PB (MOEH_ANOGA) mRNA, complete cds K05763 MSN moesin http://www.genome.jp/dbget-bin/www_bget?ko:K05763 Q170J7 2316 3.1e-259 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF05531//PF03114//PF00887//PF00018//PF14604//PF00769 Nucleopolyhedrovirus P10 protein//BAR domain//Acyl CoA binding protein//SH3 domain//Variant SH3 domain//Ezrin/radixin/moesin family -- -- GO:0000062//GO:0008092//GO:0005515 fatty-acyl-CoA binding//cytoskeletal protein binding//protein binding GO:0019898//GO:0019028//GO:0005737 extrinsic component of membrane//viral capsid//cytoplasm KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.3880 BP_3 13.00 0.79 1080 795010007 XP_011864749.1 476 4.5e-45 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00961//PF01498 LAGLIDADG endonuclease//Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677//GO:0004519 DNA binding//endonuclease activity -- -- -- -- Cluster-8309.38800 BP_3 17308.41 267.28 3413 820865920 XP_012349428.1 695 5.7e-70 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105736982 [Apis florea] 32527555 AY210843.1 1631 0 Tenebrio sp. JMM-2003 5.8S ribosomal RNA gene, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM7 161 2.0e-09 Putative uncharacterized protein ART2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART2 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38802 BP_3 276.53 3.03 4688 270014816 EFA11264.1 2443 1.6e-272 hypothetical protein TcasGA2_TC010799 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B6RSP1 355 8.6e-32 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38803 BP_3 1089.49 24.54 2432 270000811 EEZ97258.1 3522 0.0e+00 hypothetical protein TcasGA2_TC011058 [Tribolium castaneum] 665799739 XM_008549577.1 371 0 PREDICTED: Microplitis demolitor dynamin-like (LOC103571419), mRNA K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 3043 0.0e+00 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF08023//PF01926//PF01031//PF02212 Frog antimicrobial peptide//50S ribosome-binding GTPase//Dynamin central region//Dynamin GTPase effector domain GO:0006952 defense response GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005576 extracellular region KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.38804 BP_3 2533.65 32.06 4101 91085615 XP_969560.1 1159 1.1e-123 PREDICTED: ubiquitin-conjugating enzyme E2 R2 [Tribolium castaneum]>gi|270010080|gb|EFA06528.1| hypothetical protein TcasGA2_TC009432 [Tribolium castaneum] 332372777 BT126567.1 238 9.26113e-119 Dendroctonus ponderosae clone DPO1125_N09 unknown mRNA K02207 UBE2R, UBC3, CDC34 ubiquitin-conjugating enzyme E2 R http://www.genome.jp/dbget-bin/www_bget?ko:K02207 Q6ZWZ2 843 1.9e-88 Ubiquitin-conjugating enzyme E2 R2 OS=Mus musculus GN=Ube2r2 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515//GO:0005524//GO:0016881 protein binding//ATP binding//acid-amino acid ligase activity -- -- KOG0425 Ubiquitin-protein ligase Cluster-8309.38805 BP_3 85.96 0.79 5505 91077304 XP_974600.1 875 1.2e-90 PREDICTED: ras-like protein 1 [Tribolium castaneum]>gi|270002086|gb|EEZ98533.1| hypothetical protein TcasGA2_TC001037 [Tribolium castaneum] 642913769 XM_969507.3 44 8.69996e-11 PREDICTED: Tribolium castaneum ras-like protein 1 (LOC663464), mRNA K07827 KRAS, KRAS2 GTPase KRas http://www.genome.jp/dbget-bin/www_bget?ko:K07827 B4JFU8 787 8.1e-82 Ras-like protein 1 OS=Drosophila grimshawi GN=Ras85D PE=3 SV=1 PF01926//PF00735//PF00205//PF08477//PF00025//PF02421//PF03193//PF04670//PF00071 50S ribosome-binding GTPase//Septin//Thiamine pyrophosphate enzyme, central domain//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family GO:0006184//GO:0007264//GO:0015684 obsolete GTP catabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0000287//GO:0030976//GO:0015093//GO:0003924 GTP binding//magnesium ion binding//thiamine pyrophosphate binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0395 Ras-related GTPase Cluster-8309.38806 BP_3 2149.04 20.19 5423 91077304 XP_974600.1 875 1.2e-90 PREDICTED: ras-like protein 1 [Tribolium castaneum]>gi|270002086|gb|EEZ98533.1| hypothetical protein TcasGA2_TC001037 [Tribolium castaneum] 642913769 XM_969507.3 44 8.56952e-11 PREDICTED: Tribolium castaneum ras-like protein 1 (LOC663464), mRNA K07827 KRAS, KRAS2 GTPase KRas http://www.genome.jp/dbget-bin/www_bget?ko:K07827 B4NJ72 787 8.0e-82 Ras-like protein 1 OS=Drosophila willistoni GN=Ras85D PE=3 SV=1 PF03193//PF00071//PF04670//PF01926//PF00205//PF00735//PF08477//PF00025//PF02421 Protein of unknown function, DUF258//Ras family//Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Thiamine pyrophosphate enzyme, central domain//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0006184//GO:0007264//GO:0015684 obsolete GTP catabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0030976//GO:0000287//GO:0015093//GO:0003924 GTP binding//thiamine pyrophosphate binding//magnesium ion binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0395 Ras-related GTPase Cluster-8309.38808 BP_3 945.00 13.35 3704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38809 BP_3 559.87 6.42 4492 642934390 XP_008197640.1 2987 0.0e+00 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Tribolium castaneum] 462277993 APGK01058794.1 35 7.13883e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 1000 1.3e-106 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553//PF00620 Acyltransferase//RhoGAP domain GO:0008152//GO:0007165 metabolic process//signal transduction GO:0016746 transferase activity, transferring acyl groups -- -- KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.38810 BP_3 193.53 2.55 3947 642913546 XP_008201056.1 1646 3.5e-180 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 645 1.7e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.38812 BP_3 180.51 11.83 1027 270013544 EFA09992.1 397 6.1e-36 hypothetical protein TcasGA2_TC012159 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38814 BP_3 652.45 16.01 2256 478257769 ENN77912.1 1740 2.5e-191 hypothetical protein YQE_05589, partial [Dendroctonus ponderosae] 118344591 NM_001078595.1 107 3.36347e-46 Takifugu rubripes transmembrane protein 57 (tmem57), mRNA >gnl|BL_ORD_ID|675048 Takifugu rubripes macoilin-2 mRNA, complete cds -- -- -- -- Q2TLY1 912 1.1e-96 Macoilin-2 OS=Danio rerio GN=tmem57b PE=2 SV=1 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane KOG1821 Uncharacterized conserved protein Cluster-8309.38815 BP_3 198.27 4.29 2517 91080689 XP_975235.1 1580 1.0e-172 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [Tribolium castaneum]>gi|270006426|gb|EFA02874.1| hypothetical protein TcasGA2_TC007967 [Tribolium castaneum] 642919565 XM_970142.2 154 2.80469e-72 PREDICTED: Tribolium castaneum NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (LOC664127), mRNA K03953 NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03953 P34943 747 1.6e-77 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Bos taurus GN=NDUFA9 PE=1 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0008210//GO:0044237 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//estrogen metabolic process//cellular metabolic process GO:0000166//GO:0003824//GO:0050662//GO:0003854//GO:0016616 nucleotide binding//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit Cluster-8309.38816 BP_3 573.83 3.53 8130 91087319 XP_975585.1 1392 2.0e-150 PREDICTED: solute carrier family 46 member 3-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q5F4B8 257 3.4e-20 Solute carrier family 46 member 3 OS=Gallus gallus GN=SLC46A3 PE=2 SV=1 PF00608//PF07690//PF03869//PF02285 Adenoviral fibre protein (repeat/shaft region)//Major Facilitator Superfamily//Arc-like DNA binding domain//Cytochrome oxidase c subunit VIII GO:0055085//GO:0006123//GO:0019062//GO:0009405//GO:0015992//GO:0007155 transmembrane transport//mitochondrial electron transport, cytochrome c to oxygen//virion attachment to host cell//pathogenesis//proton transport//cell adhesion GO:0003677//GO:0004129 DNA binding//cytochrome-c oxidase activity GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.38817 BP_3 1470.00 24.33 3204 189238710 XP_969341.2 1002 1.3e-105 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050 Flagellar FliJ protein GO:0006935//GO:0071973 chemotaxis//bacterial-type flagellum-dependent cell motility GO:0003774 motor activity GO:0016020//GO:0009288 membrane//bacterial-type flagellum -- -- Cluster-8309.38818 BP_3 74.02 3.11 1440 189237561 XP_974680.2 1046 4.8e-111 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38819 BP_3 974.81 8.70 5691 197276682 NP_001127850.1 2992 0.0e+00 smoothened precursor [Tribolium castaneum]>gi|270012713|gb|EFA09161.1| smoothened [Tribolium castaneum] 645012677 XM_001604820.3 303 9.47841e-155 PREDICTED: Nasonia vitripennis uncharacterized LOC100119467 (LOC100119467), mRNA K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 P91682 1824 4.8e-202 Protein smoothened OS=Drosophila melanogaster GN=smo PE=1 SV=1 PF06573//PF01534//PF01392 Churchill protein//Frizzled/Smoothened family membrane region//Fz domain GO:0007275//GO:0007166//GO:0007186//GO:0045893//GO:0007224 multicellular organismal development//cell surface receptor signaling pathway//G-protein coupled receptor signaling pathway//positive regulation of transcription, DNA-templated//smoothened signaling pathway GO:0005515//GO:0004930//GO:0008270 protein binding//G-protein coupled receptor activity//zinc ion binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.38823 BP_3 1566.00 18.88 4289 642930971 XP_008196161.1 2103 3.9e-233 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103313779 [Tribolium castaneum] 642930970 XM_008197939.1 332 5.39494e-171 PREDICTED: Tribolium castaneum uncharacterized LOC103313779 (LOC103313779), mRNA K04650 NCOR1, N-CoR nuclear receptor co-repressor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04650 O75376 895 1.9e-94 Nuclear receptor corepressor 1 OS=Homo sapiens GN=NCOR1 PE=1 SV=2 PF01775 Ribosomal L18ae/LX protein domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1878 Nuclear receptor coregulator SMRT/SMRTER, contains Myb-like domains Cluster-8309.38824 BP_3 1932.89 24.95 4025 91086855 XP_974363.1 1684 1.4e-184 PREDICTED: zinc finger protein 91 [Tribolium castaneum]>gi|270009694|gb|EFA06142.1| hypothetical protein TcasGA2_TC008986 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q3SZD7 562 7.3e-56 Carbonyl reductase [NADPH] 1 OS=Bos taurus GN=CBR1 PE=2 SV=1 PF01370//PF13912//PF00106//PF00096//PF13465 NAD dependent epimerase/dehydratase family//C2H2-type zinc finger//short chain dehydrogenase//Zinc finger, C2H2 type//Zinc-finger double domain GO:0008152 metabolic process GO:0050662//GO:0003824//GO:0016491//GO:0046872 coenzyme binding//catalytic activity//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.38825 BP_3 1406.55 2.90 23673 270014225 EFA10673.1 9007 0.0e+00 muscle-specific protein 300 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 816 1.5e-84 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF00435//PF00837//PF14867//PF10541 Spectrin repeat//Iodothyronine deiodinase//Lantibiotic alpha//Nuclear envelope localisation domain GO:0050830//GO:0055114 defense response to Gram-positive bacterium//oxidation-reduction process GO:0004800//GO:0005515 thyroxine 5'-deiodinase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.38826 BP_3 303.00 14.30 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38827 BP_3 508.93 7.06 3764 546685733 ERL95188.1 972 4.8e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 3.2e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF14634//PF13639 zinc-RING finger domain//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.38828 BP_3 711.13 3.45 10223 815803119 XP_012222254.1 2358 2.5e-262 PREDICTED: ATP-binding cassette sub-family G member 4 isoform X1 [Linepithema humile]>gi|815803121|ref|XP_012222255.1| PREDICTED: ATP-binding cassette sub-family G member 4 isoform X1 [Linepithema humile] 462304009 APGK01049651.1 110 3.31344e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 871 2.7e-91 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF01637//PF08176//PF02899//PF00005//PF03193//PF13895//PF00041//PF16656//PF07714//PF01061//PF01926//PF13304//PF00621//PF00069//PF03931 Archaeal ATPase//Small acid-soluble spore protein K family//Phage integrase, N-terminal SAM-like domain//ABC transporter//Protein of unknown function, DUF258//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Protein tyrosine kinase//ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//RhoGEF domain//Protein kinase domain//Skp1 family, tetramerisation domain GO:0030436//GO:0019497//GO:0006468//GO:0035023//GO:0015074//GO:0006771//GO:0043087//GO:0006511 asexual sporulation//hexachlorocyclohexane metabolic process//protein phosphorylation//regulation of Rho protein signal transduction//DNA integration//riboflavin metabolic process//regulation of GTPase activity//ubiquitin-dependent protein catabolic process GO:0016887//GO:0003993//GO:0003924//GO:0005524//GO:0046872//GO:0004672//GO:0005089//GO:0005525//GO:0005515//GO:0003677 ATPase activity//acid phosphatase activity//GTPase activity//ATP binding//metal ion binding//protein kinase activity//Rho guanyl-nucleotide exchange factor activity//GTP binding//protein binding//DNA binding GO:0042601//GO:0016020 endospore-forming forespore//membrane -- -- Cluster-8309.38831 BP_3 2553.97 60.07 2341 167234457 NP_001107844.1 1519 1.1e-165 eukaryotic translation initiation factor 5 [Tribolium castaneum]>gi|642919625|ref|XP_008191995.1| PREDICTED: eukaryotic translation initiation factor 5 isoform X1 [Tribolium castaneum]>gi|270005452|gb|EFA01900.1| hypothetical protein TcasGA2_TC007510 [Tribolium castaneum] 167234456 NM_001114372.1 122 1.60193e-54 Tribolium castaneum eukaryotic translation initiation factor 5 (Eif5), mRNA K03262 EIF5 translation initiation factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03262 Q9VXK6 1299 1.5e-141 Eukaryotic translation initiation factor 5 OS=Drosophila melanogaster GN=eIF5 PE=1 SV=1 PF01873//PF02020//PF14489 Domain found in IF2B/IF5//eIF4-gamma/eIF5/eIF2-epsilon//QueF-like protein GO:0006413//GO:0016070//GO:0006446//GO:0008616 translational initiation//RNA metabolic process//regulation of translational initiation//queuosine biosynthetic process GO:0033739//GO:0005515//GO:0003743 preQ1 synthase activity//protein binding//translation initiation factor activity GO:0005840 ribosome KOG2767 Translation initiation factor 5 (eIF-5) Cluster-8309.38832 BP_3 7.23 0.90 680 91088569 XP_973042.1 388 4.5e-35 PREDICTED: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011703|gb|EFA08151.1| hypothetical protein TcasGA2_TC005769 [Tribolium castaneum] -- -- -- -- -- K00022 HADH 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00022 Q16836 292 2.5e-25 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3 PF00725//PF02276//PF02737 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//Photosynthetic reaction centre cytochrome C subunit//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0018874//GO:0006633//GO:0006631//GO:0006552//GO:0006550//GO:0006574//GO:0006568//GO:0006118//GO:0006554//GO:0019684//GO:0055114 benzoate metabolic process//fatty acid biosynthetic process//fatty acid metabolic process//leucine catabolic process//isoleucine catabolic process//valine catabolic process//tryptophan metabolic process//obsolete electron transport//lysine catabolic process//photosynthesis, light reaction//oxidation-reduction process GO:0016491//GO:0070403//GO:0009055//GO:0020037//GO:0003857//GO:0005506 oxidoreductase activity//NAD+ binding//electron carrier activity//heme binding//3-hydroxyacyl-CoA dehydrogenase activity//iron ion binding GO:0030077 plasma membrane light-harvesting complex KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.38833 BP_3 1721.40 58.17 1718 91088569 XP_973042.1 1240 1.8e-133 PREDICTED: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011703|gb|EFA08151.1| hypothetical protein TcasGA2_TC005769 [Tribolium castaneum] -- -- -- -- -- K00022 HADH 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00022 Q9WVK7 921 7.3e-98 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Hadh PE=2 SV=1 PF02276//PF03446//PF01134//PF13241//PF11965//PF00725//PF07992//PF02737//PF00185//PF03721//PF00070//PF01210//PF01266//PF03435//PF12831//PF02254 Photosynthetic reaction centre cytochrome C subunit//NAD binding domain of 6-phosphogluconate dehydrogenase//Glucose inhibited division protein A//Putative NAD(P)-binding//Domain of unknown function (DUF3479)//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//TrkA-N domain GO:0055114//GO:0006779//GO:0006554//GO:0006118//GO:0006568//GO:0015994//GO:0019354//GO:0006098//GO:0006633//GO:0018874//GO:0046168//GO:0006552//GO:0006550//GO:0006574//GO:0019684//GO:0008033//GO:0019521//GO:0006813//GO:0006520//GO:0006631 oxidation-reduction process//porphyrin-containing compound biosynthetic process//lysine catabolic process//obsolete electron transport//tryptophan metabolic process//chlorophyll metabolic process//siroheme biosynthetic process//pentose-phosphate shunt//fatty acid biosynthetic process//benzoate metabolic process//glycerol-3-phosphate catabolic process//leucine catabolic process//isoleucine catabolic process//valine catabolic process//photosynthesis, light reaction//tRNA processing//D-gluconate metabolic process//potassium ion transport//cellular amino acid metabolic process//fatty acid metabolic process GO:0016616//GO:0005506//GO:0016743//GO:0016491//GO:0043115//GO:0020037//GO:0016597//GO:0016851//GO:0003857//GO:0004616//GO:0051287//GO:0070403//GO:0009055//GO:0050660 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//iron ion binding//carboxyl- or carbamoyltransferase activity//oxidoreductase activity//precorrin-2 dehydrogenase activity//heme binding//amino acid binding//magnesium chelatase activity//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding//NAD+ binding//electron carrier activity//flavin adenine dinucleotide binding GO:0010007//GO:0030077 magnesium chelatase complex//plasma membrane light-harvesting complex KOG2304 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.38834 BP_3 48.18 25.11 382 668447831 KFB37571.1 138 2.5e-06 AGAP011345-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07851//PF10147 TMPIT-like protein//Growth arrest and DNA-damage-inducible proteins-interacting protein 1 GO:0007049 cell cycle -- -- GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.38835 BP_3 676.12 30.85 1348 189234912 XP_969611.2 1065 2.8e-113 PREDICTED: poly(rC)-binding protein 3 isoform X3 [Tribolium castaneum] 642914804 XM_964518.3 498 0 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X5, mRNA K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 P57722 455 6.3e-44 Poly(rC)-binding protein 3 OS=Mus musculus GN=Pcbp3 PE=2 SV=3 PF07650//PF00013//PF13014//PF13184 KH domain//KH domain//KH domain//NusA-like KH domain -- -- GO:0003723 RNA binding -- -- KOG2190 PolyC-binding proteins alphaCP-1 and related KH domain proteins Cluster-8309.38836 BP_3 932.30 9.10 5228 91076774 XP_973840.1 1189 4.6e-127 PREDICTED: autophagy protein 5 [Tribolium castaneum]>gi|270001850|gb|EEZ98297.1| hypothetical protein TcasGA2_TC000747 [Tribolium castaneum] 170060949 XM_001865993.1 65 1.75028e-22 Culex quinquefasciatus Autophagy-specific protein, mRNA K08339 ATG5 autophagy-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08339 Q9W3R7 857 5.9e-90 Autophagy protein 5 OS=Drosophila melanogaster GN=Atg5 PE=2 SV=2 PF06309//PF07728//PF04106//PF16094 Torsin//AAA domain (dynein-related subfamily)//Autophagy protein Apg5//Proteasome assembly chaperone 4 GO:0043248//GO:0006914 proteasome assembly//autophagy GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0005783//GO:0005737 endoplasmic reticulum//cytoplasm KOG2170 ATPase of the AAA+ superfamily Cluster-8309.38837 BP_3 727.59 4.24 8567 642918090 XP_008193957.1 2255 1.8e-250 PREDICTED: uncharacterized protein LOC103313170 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17480 AATK, LMTK1 lemur tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17480 Q6ZMQ8 601 4.7e-60 Serine/threonine-protein kinase LMTK1 OS=Homo sapiens GN=AATK PE=1 SV=2 PF00069//PF07714//PF14991 Protein kinase domain//Protein tyrosine kinase//Protein melan-A GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0042470 melanosome -- -- Cluster-8309.38838 BP_3 1122.28 7.89 7149 642912301 XP_968800.3 1228 1.9e-131 PREDICTED: protein couch potato isoform X2 [Tribolium castaneum] 642912300 XM_963707.3 407 0 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X2, mRNA -- -- -- -- Q01617 796 9.6e-83 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00168//PF00076 C2 domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.38841 BP_3 269.80 1.01 13140 642918534 XP_008191512.1 3764 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.79358e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1207 3.9e-130 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF13895//PF05461//PF02383 Immunoglobulin domain//Apolipoprotein L//SacI homology domain GO:0042157//GO:0006869 lipoprotein metabolic process//lipid transport GO:0042578//GO:0008289//GO:0005515 phosphoric ester hydrolase activity//lipid binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.38842 BP_3 1928.78 54.26 2005 546674732 ERL86041.1 1235 8.1e-133 hypothetical protein D910_03455 [Dendroctonus ponderosae] 808119683 XM_012307943.1 60 3.99817e-20 PREDICTED: Bombus terrestris 40S ribosomal protein S28 (LOC105665663), mRNA K07050 AARSD1, ALAX misacylated tRNA(Ala) deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K07050 Q7ZYJ9 822 2.6e-86 Alanyl-tRNA editing protein Aarsd1-B OS=Xenopus laevis GN=aarsd1-b PE=2 SV=1 PF01176//PF07973//PF03367//PF01200//PF01411 Translation initiation factor 1A / IF-1//Threonyl and Alanyl tRNA synthetase second additional domain//ZPR1 zinc-finger domain//Ribosomal protein S28e//tRNA synthetases class II (A) GO:0042254//GO:0006522//GO:0006413//GO:0043039//GO:0006419//GO:0006446//GO:0006412//GO:0006531 ribosome biogenesis//alanine metabolic process//translational initiation//tRNA aminoacylation//alanyl-tRNA aminoacylation//regulation of translational initiation//translation//aspartate metabolic process GO:0008270//GO:0000166//GO:0003735//GO:0016876//GO:0003743//GO:0005524//GO:0003723//GO:0004813 zinc ion binding//nucleotide binding//structural constituent of ribosome//ligase activity, forming aminoacyl-tRNA and related compounds//translation initiation factor activity//ATP binding//RNA binding//alanine-tRNA ligase activity GO:0005622//GO:0005840 intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-8309.38843 BP_3 51.81 1.02 2740 546683268 ERL93100.1 388 1.8e-34 hypothetical protein D910_10402 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38844 BP_3 57.04 0.36 7987 91079889 XP_968047.1 4173 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 6.89145e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 2.5e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF14560//PF00240//PF00443 Ubiquitin-like domain//Ubiquitin family//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0005515 ubiquitinyl hydrolase activity//protein binding -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.38847 BP_3 21.31 0.76 1641 91076824 XP_967870.1 591 3.1e-58 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 435 1.6e-41 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.38849 BP_3 287.61 1.66 8641 91084687 XP_968830.1 2631 4.7e-294 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] 831284033 XM_012817767.1 98 1.31141e-40 PREDICTED: Clupea harengus myotubularin-related protein 3-like (LOC105891591), mRNA K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q13615 1526 2.6e-167 Myotubularin-related protein 3 OS=Homo sapiens GN=MTMR3 PE=1 SV=3 PF00782//PF01363//PF00400//PF07646//PF00102 Dual specificity phosphatase, catalytic domain//FYVE zinc finger//WD domain, G-beta repeat//Kelch motif//Protein-tyrosine phosphatase GO:0035335//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0046872//GO:0004725//GO:0005515//GO:0008138 metal ion binding//protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.38850 BP_3 445.01 29.49 1019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83653 208 2.1e-15 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.38851 BP_3 733.49 23.92 1770 91091796 XP_970426.1 1783 2.0e-196 PREDICTED: dynactin subunit 4 [Tribolium castaneum]>gi|270001091|gb|EEZ97538.1| hypothetical protein TcasGA2_TC011388 [Tribolium castaneum] -- -- -- -- -- K10426 DCTN4 dynactin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10426 Q9UJW0 746 1.5e-77 Dynactin subunit 4 OS=Homo sapiens GN=DCTN4 PE=1 SV=1 PF02529//PF05502 Cytochrome B6-F complex subunit 5//Dynactin p62 family -- -- -- -- GO:0005869//GO:0009512 dynactin complex//cytochrome b6f complex KOG3896 Dynactin, subunit p62 Cluster-8309.38852 BP_3 193.17 3.03 3367 642920452 XP_008192356.1 661 4.9e-66 PREDICTED: protein croquemort isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 460 4.1e-44 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.38854 BP_3 4833.95 18.93 12602 270001906 EEZ98353.1 491 9.5e-46 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07716//PF00170//PF04384//PF03131 Basic region leucine zipper//bZIP transcription factor//Iron-sulphur cluster assembly//bZIP Maf transcription factor GO:0006355//GO:0016226 regulation of transcription, DNA-templated//iron-sulfur cluster assembly GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.38856 BP_3 392.49 30.26 917 642913524 XP_008201050.1 213 1.2e-14 PREDICTED: venom allergen 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38859 BP_3 107419.69 3939.50 1606 350406035 XP_003487634.1 231 1.7e-16 PREDICTED: pro-resilin [Bombus impatiens] 642925500 XM_963805.3 51 3.21102e-15 PREDICTED: Tribolium castaneum pro-resilin (LOC657340), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3886 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38860 BP_3 312.85 63.52 529 270013347 EFA09795.1 558 6.8e-55 hypothetical protein TcasGA2_TC011937 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 418 4.8e-40 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38861 BP_3 1220.00 26.37 2522 642935430 XP_008198007.1 885 3.9e-92 PREDICTED: LOW QUALITY PROTEIN: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum] 195450978 XM_002072679.1 142 1.31681e-65 Drosophila willistoni GK13751 (Dwil\GK13751), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 663 8.9e-68 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38865 BP_3 139.99 1.13 6286 478249797 ENN70304.1 1981 8.0e-219 hypothetical protein YQE_12815, partial [Dendroctonus ponderosae] -- -- -- -- -- K17785 IMMT, FCJ1, MNOS2 mitofilin http://www.genome.jp/dbget-bin/www_bget?ko:K17785 P91928 1173 1.6e-126 MICOS complex subunit Mic60 OS=Drosophila melanogaster GN=Mitofilin PE=1 SV=4 PF10759//PF01632//PF01557 Protein of unknown function (DUF2587)//Ribosomal protein L35//Fumarylacetoacetate (FAA) hydrolase family GO:0042254//GO:0008152//GO:0061136//GO:0006412 ribosome biogenesis//metabolic process//regulation of proteasomal protein catabolic process//translation GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG1854 Mitochondrial inner membrane protein (mitofilin) Cluster-8309.38867 BP_3 1055.46 10.14 5310 642926171 XP_008194814.1 2757 7.0e-309 PREDICTED: vinculin isoform X4 [Tribolium castaneum]>gi|270008539|gb|EFA04987.1| hypothetical protein TcasGA2_TC015066 [Tribolium castaneum] 665389295 NM_001297885.1 65 1.77793e-22 Drosophila melanogaster vinculin (Vinc), transcript variant C, mRNA K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 2024 2.9e-225 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF04513//PF09141//PF01442 Vinculin family//Baculovirus polyhedron envelope protein, PEP, C terminus//Talin, middle domain//Apolipoprotein A1/A4/E domain GO:0042157//GO:0007016//GO:0006869//GO:0007155 lipoprotein metabolic process//cytoskeletal anchoring at plasma membrane//lipid transport//cell adhesion GO:0008289//GO:0005198//GO:0051015//GO:0005200 lipid binding//structural molecule activity//actin filament binding//structural constituent of cytoskeleton GO:0005925//GO:0005856//GO:0019028//GO:0001726//GO:0019031//GO:0015629//GO:0005576 focal adhesion//cytoskeleton//viral capsid//ruffle//viral envelope//actin cytoskeleton//extracellular region KOG3681 Alpha-catenin Cluster-8309.38868 BP_3 21.30 0.58 2064 332373698 AEE61990.1 2413 2.1e-269 unknown [Dendroctonus ponderosae] 630581065 KF383704.1 194 1.33195e-94 Tectarchus salebrosus isolate TES phosphoglucose isomerase (Pgi) mRNA, Pgi-1 allele, partial cds K01810 GPI, pgi glucose-6-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01810 P52031 2136 1.1e-238 Glucose-6-phosphate isomerase OS=Drosophila yakuba GN=Pgi PE=3 SV=1 PF11593//PF02792//PF00342 Mediator complex subunit 3 fungal//Mago nashi protein//Phosphoglucose isomerase GO:0005985//GO:0005982//GO:0006098//GO:0006096//GO:0006357//GO:0006094 sucrose metabolic process//starch metabolic process//pentose-phosphate shunt//glycolytic process//regulation of transcription from RNA polymerase II promoter//gluconeogenesis GO:0001104//GO:0004347 RNA polymerase II transcription cofactor activity//glucose-6-phosphate isomerase activity GO:0016592//GO:0005634 mediator complex//nucleus KOG2446 Glucose-6-phosphate isomerase Cluster-8309.38869 BP_3 2111.00 48.84 2375 91077746 XP_966706.1 2391 8.6e-267 PREDICTED: uncharacterized protein LOC655102 [Tribolium castaneum]>gi|270001518|gb|EEZ97965.1| hypothetical protein TcasGA2_TC000357 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38870 BP_3 2090.84 43.01 2635 546684091 ERL93810.1 2181 2.1e-242 hypothetical protein D910_11096 [Dendroctonus ponderosae] -- -- -- -- -- K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 P45844 1291 1.4e-140 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF03193//PF00005//PF13304//PF01926//PF01061 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter -- -- GO:0003924//GO:0016887//GO:0005525//GO:0005524 GTPase activity//ATPase activity//GTP binding//ATP binding GO:0016020 membrane -- -- Cluster-8309.38871 BP_3 34.46 0.45 4009 478263722 ENN82025.1 960 1.3e-100 hypothetical protein YQE_01600, partial [Dendroctonus ponderosae] 769857176 XM_011641913.1 129 3.54396e-58 PREDICTED: Pogonomyrmex barbatus 40S ribosomal protein S23 (LOC105429139), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q6EV23 449 9.2e-43 40S ribosomal protein S23 OS=Papilio dardanus GN=RpS23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1749 40S ribosomal protein S23 Cluster-8309.38872 BP_3 4035.64 33.38 6119 642910289 XP_008198706.1 2720 1.6e-304 PREDICTED: U2 snRNP-associated SURP motif-containing protein-like [Tribolium castaneum] -- -- -- -- -- K12842 SR140 U2-associated protein SR140 http://www.genome.jp/dbget-bin/www_bget?ko:K12842 Q5R7X2 1646 2.2e-181 U2 snRNP-associated SURP motif-containing protein OS=Pongo abelii GN=U2SURP PE=2 SV=1 PF11051//PF00076//PF16367//PF01501//PF01805 Mannosyltransferase putative//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Glycosyl transferase family 8//Surp module GO:0006486//GO:0006396 protein glycosylation//RNA processing GO:0016757//GO:0003723//GO:0003676 transferase activity, transferring glycosyl groups//RNA binding//nucleic acid binding -- -- KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains Cluster-8309.38874 BP_3 16.42 0.36 2505 642929001 XP_008195650.1 2028 1.1e-224 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 845 7.0e-89 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF08686//PF05986 PLAC (protease and lacunin) domain//ADAM-TS Spacer 1 -- -- GO:0004222//GO:0008233 metalloendopeptidase activity//peptidase activity GO:0031012 extracellular matrix KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.38876 BP_3 504.84 2.65 9476 617652370 XP_007534385.1 565 1.9e-54 PREDICTED: zinc finger protein 14-like [Erinaceus europaeus] -- -- -- -- -- -- -- -- -- Q03938 512 1.1e-49 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF13465//PF00096//PF13912//PF00230//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Major intrinsic protein//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0006810 transport GO:0046872//GO:0005215//GO:0008270 metal ion binding//transporter activity//zinc ion binding GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.38878 BP_3 512.93 8.33 3261 91088017 XP_974079.1 1338 1.5e-144 PREDICTED: graves disease carrier protein [Tribolium castaneum]>gi|270011890|gb|EFA08338.1| hypothetical protein TcasGA2_TC005981 [Tribolium castaneum] -- -- -- -- -- K15084 SLC25A16, GDA, LEU5 solute carrier family 25 (mitochondrial carrier protein), member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15084 Q8C0K5 814 3.6e-85 Graves disease carrier protein homolog OS=Mus musculus GN=Slc25a16 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0005743//GO:0016021 mitochondrial inner membrane//integral component of membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.38879 BP_3 99.53 0.76 6641 91085003 XP_973266.1 2982 0.0e+00 PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|642926204|ref|XP_008194828.1| PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|270009020|gb|EFA05468.1| hypothetical protein TcasGA2_TC015651 [Tribolium castaneum] 194742159 XM_001953538.1 227 1.95948e-112 Drosophila ananassae GF17161 (Dana\GF17161), mRNA K00693 GYS glycogen(starch) synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00693 Q9VFC8 2563 1.1e-287 Glycogen [starch] synthase OS=Drosophila melanogaster GN=GlyS PE=1 SV=2 PF02535//PF05693//PF00439 ZIP Zinc transporter//Glycogen synthase//Bromodomain GO:0005985//GO:0055085//GO:0030001//GO:0005982//GO:0005978 sucrose metabolic process//transmembrane transport//metal ion transport//starch metabolic process//glycogen biosynthetic process GO:0004373//GO:0005515//GO:0046873 glycogen (starch) synthase activity//protein binding//metal ion transmembrane transporter activity GO:0016020 membrane KOG3742 Glycogen synthase Cluster-8309.38881 BP_3 426.00 7.76 2939 478261514 ENN80859.1 850 5.2e-88 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P13582 498 1.4e-48 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38886 BP_3 64.57 0.50 6537 642918446 XP_008191478.1 2992 0.0e+00 PREDICTED: protein zer-1 homolog [Tribolium castaneum]>gi|270003243|gb|EEZ99690.1| hypothetical protein TcasGA2_TC002447 [Tribolium castaneum] 769838188 XM_011631947.1 151 3.41518e-70 PREDICTED: Pogonomyrmex barbatus probable deoxyhypusine synthase (LOC105422536), transcript variant X6, mRNA K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q9W0E8 1706 2.6e-188 Protein zer-1 homolog OS=Drosophila melanogaster GN=CG12084 PE=2 SV=2 PF00560//PF02765//PF03792//PF13855//PF00514//PF01916 Leucine Rich Repeat//Telomeric single stranded DNA binding POT1/CDC13//PBC domain//Leucine rich repeat//Armadillo/beta-catenin-like repeat//Deoxyhypusine synthase GO:0000723//GO:0008612 telomere maintenance//peptidyl-lysine modification to peptidyl-hypusine GO:0003700//GO:0005515//GO:0003677 transcription factor activity, sequence-specific DNA binding//protein binding//DNA binding GO:0000784//GO:0005667//GO:0005634 nuclear chromosome, telomeric region//transcription factor complex//nucleus KOG2924 Deoxyhypusine synthase Cluster-8309.38889 BP_3 40.78 0.37 5570 642923061 XP_008200515.1 1804 2.4e-198 PREDICTED: sphingomyelin synthase-related 1-like [Tribolium castaneum]>gi|270006596|gb|EFA03044.1| hypothetical protein TcasGA2_TC010470 [Tribolium castaneum] 755974579 XM_011309074.1 145 6.2959e-67 PREDICTED: Fopius arisanus sphingomyelin synthase-related 1 (LOC105269082), mRNA -- -- -- -- Q9VS60 1131 1.1e-121 Sphingomyelin synthase-related 1 OS=Drosophila melanogaster GN=SMSr PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3330 Transport protein particle (TRAPP) complex subunit Cluster-8309.38890 BP_3 23.64 0.45 2797 642936148 XP_008198317.1 2326 3.5e-259 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Tribolium castaneum] 571506739 XM_397111.4 230 1.76135e-114 PREDICTED: Apis mellifera f-box/LRR-repeat protein 2-like (LOC413670), transcript variant X1, mRNA -- -- -- -- Q8BH16 205 1.3e-14 F-box/LRR-repeat protein 2 OS=Mus musculus GN=Fbxl2 PE=1 SV=1 PF13639//PF12937//PF00646//PF15966 Ring finger domain//F-box-like//F-box domain//F-box -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.38892 BP_3 488.32 7.95 3253 91076670 XP_971562.1 2366 9.4e-264 PREDICTED: ATP-binding cassette sub-family F member 1 [Tribolium castaneum]>gi|270002367|gb|EEZ98814.1| hypothetical protein TcasGA2_TC004420 [Tribolium castaneum] 194889494 XM_001977061.1 234 1.22643e-116 Drosophila erecta GG18434 (Dere\GG18434), mRNA K06184 ABCF1 ATP-binding cassette, subfamily F, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06184 Q767L0 1714 1.5e-189 ATP-binding cassette sub-family F member 1 OS=Sus scrofa GN=ABCF1 PE=3 SV=1 PF07213//PF00004//PF13304//PF01926//PF00488//PF08477//PF07728//PF00910//PF01008//PF02367//PF00005//PF03193//PF03266 DAP10 membrane protein//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//MutS domain V//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//RNA helicase//Initiation factor 2 subunit family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258//NTPase GO:0014068//GO:0006298//GO:0007264//GO:0002949//GO:0044237//GO:0006200//GO:0007165//GO:0050776 positive regulation of phosphatidylinositol 3-kinase signaling//mismatch repair//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//cellular metabolic process//obsolete ATP catabolic process//signal transduction//regulation of immune response GO:0003723//GO:0003724//GO:0005525//GO:0043548//GO:0003924//GO:0005524//GO:0098519//GO:0005102//GO:0030983//GO:0016887 RNA binding//RNA helicase activity//GTP binding//phosphatidylinositol 3-kinase binding//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//receptor binding//mismatched DNA binding//ATPase activity GO:0016020 membrane KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.38893 BP_3 25.42 0.39 3398 189238048 XP_001811309.1 1686 6.9e-185 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 2.4e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF01073//PF01370//PF03015 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Male sterility protein GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0050662//GO:0003824//GO:0003854//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.38895 BP_3 656.62 14.81 2428 91086105 XP_967675.1 1968 9.9e-218 PREDICTED: long-chain fatty acid transport protein 4-like [Tribolium castaneum] 674034499 XM_008840881.1 44 3.80793e-11 PREDICTED: Nannospalax galili solute carrier family 27 (fatty acid transporter), member 6 (Slc27a6), mRNA K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K08745 Q91VE0 1415 5.4e-155 Long-chain fatty acid transport protein 4 OS=Mus musculus GN=Slc27a4 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.38897 BP_3 1541.00 39.44 2175 642922463 XP_008193182.1 2033 2.6e-225 PREDICTED: integrin beta-PS [Tribolium castaneum] -- -- -- -- -- K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 1437 1.4e-157 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.38898 BP_3 1062.45 7.65 6983 642920095 XP_008192202.1 1742 4.6e-191 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 7.73392e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.1e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38900 BP_3 1720.31 11.03 7812 546679672 ERL90099.1 3727 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 1922 2.8e-213 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF08141//PF02826//PF03446//PF00389//PF03493 Small acid-soluble spore protein H family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit GO:0006813//GO:0006098//GO:0008152//GO:0055114//GO:0019521//GO:0030436 potassium ion transport//pentose-phosphate shunt//metabolic process//oxidation-reduction process//D-gluconate metabolic process//asexual sporulation GO:0015269//GO:0016616//GO:0051287//GO:0004616 calcium-activated potassium channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//phosphogluconate dehydrogenase (decarboxylating) activity GO:0042601//GO:0016020 endospore-forming forespore//membrane KOG1998 Signaling protein DOCK180 Cluster-8309.38902 BP_3 8330.64 707.84 859 270003816 EFA00264.1 1006 1.2e-106 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] 255522810 NM_001163846.1 287 1.08488e-146 Tribolium castaneum longitudinals lacking (Lola), transcript variant 9, mRNA -- -- -- -- Q9V5M6 553 1.7e-55 Longitudinals lacking protein, isoforms J/P/Q/S/Z OS=Drosophila melanogaster GN=lola PE=1 SV=4 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38903 BP_3 740.19 5.27 7064 642915492 XP_008190639.1 723 6.7e-73 PREDICTED: glycerol kinase [Tribolium castaneum]>gi|642915494|ref|XP_008190640.1| PREDICTED: glycerol kinase [Tribolium castaneum]>gi|270003860|gb|EFA00308.1| hypothetical protein TcasGA2_TC003143 [Tribolium castaneum] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q64516 446 3.6e-42 Glycerol kinase OS=Mus musculus GN=Gk PE=2 SV=2 PF00370//PF05480//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//Staphylococcus haemolytic protein//FGGY family of carbohydrate kinases, C-terminal domain GO:0006072//GO:0009405//GO:0016310//GO:0005975//GO:0046486 glycerol-3-phosphate metabolic process//pathogenesis//phosphorylation//carbohydrate metabolic process//glycerolipid metabolic process GO:0016773//GO:0004370 phosphotransferase activity, alcohol group as acceptor//glycerol kinase activity -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.38905 BP_3 141.79 1.20 6004 642915492 XP_008190639.1 842 9.0e-87 PREDICTED: glycerol kinase [Tribolium castaneum]>gi|642915494|ref|XP_008190640.1| PREDICTED: glycerol kinase [Tribolium castaneum]>gi|270003860|gb|EFA00308.1| hypothetical protein TcasGA2_TC003143 [Tribolium castaneum] 572304237 XM_006618025.1 72 2.58419e-26 PREDICTED: Apis dorsata putative glycerol kinase 3-like (LOC102680807), transcript variant X7, mRNA K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q64516 613 1.3e-61 Glycerol kinase OS=Mus musculus GN=Gk PE=2 SV=2 PF02782//PF00370 FGGY family of carbohydrate kinases, C-terminal domain//FGGY family of carbohydrate kinases, N-terminal domain GO:0016310//GO:0046486//GO:0005975//GO:0006072 phosphorylation//glycerolipid metabolic process//carbohydrate metabolic process//glycerol-3-phosphate metabolic process GO:0004370//GO:0016773 glycerol kinase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.38906 BP_3 13.14 0.55 1437 91079686 XP_967889.1 1150 4.2e-123 PREDICTED: signal recognition particle 54 kDa protein [Tribolium castaneum]>gi|270003347|gb|EEZ99794.1| hypothetical protein TcasGA2_TC002574 [Tribolium castaneum] 242009195 XM_002425332.1 330 2.30128e-170 Pediculus humanus corporis Signal recognition particle 54 kDa protein, putative, mRNA K03106 SRP54, ffh signal recognition particle subunit SRP54 http://www.genome.jp/dbget-bin/www_bget?ko:K03106 Q6AYB5 1039 1.3e-111 Signal recognition particle 54 kDa protein OS=Rattus norvegicus GN=Srp54 PE=2 SV=1 PF10662//PF03205//PF04851//PF06414//PF00004//PF02978//PF01591//PF02881//PF00448//PF01583//PF01926 Ethanolamine utilisation - propanediol utilisation//Molybdopterin guanine dinucleotide synthesis protein B//Type III restriction enzyme, res subunit//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Signal peptide binding domain//6-phosphofructo-2-kinase//SRP54-type protein, helical bundle domain//SRP54-type protein, GTPase domain//Adenylylsulphate kinase//50S ribosome-binding GTPase GO:0006013//GO:0006184//GO:0000103//GO:0006144//GO:0006576//GO:0006000//GO:0006777//GO:0006614 mannose metabolic process//obsolete GTP catabolic process//sulfate assimilation//purine nucleobase metabolic process//cellular biogenic amine metabolic process//fructose metabolic process//Mo-molybdopterin cofactor biosynthetic process//SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0005525//GO:0004020//GO:0003873//GO:0003677//GO:0016301//GO:0003924//GO:0016787//GO:0005524 7S RNA binding//GTP binding//adenylylsulfate kinase activity//6-phosphofructo-2-kinase activity//DNA binding//kinase activity//GTPase activity//hydrolase activity//ATP binding GO:0048500 signal recognition particle KOG0780 Signal recognition particle, subunit Srp54 Cluster-8309.38907 BP_3 49.77 2.31 1330 642912259 XP_008200626.1 559 1.3e-54 PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|642912261|ref|XP_008200627.1| PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|270002461|gb|EEZ98908.1| hypothetical protein TcasGA2_TC004527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92628 208 2.7e-15 Uncharacterized protein KIAA0232 OS=Homo sapiens GN=KIAA0232 PE=1 SV=5 PF12169 DNA polymerase III subunits gamma and tau domain III GO:0006260 DNA replication GO:0003887 DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.38908 BP_3 1147.44 5.87 9713 91092856 XP_969290.1 11458 0.0e+00 PREDICTED: protein furry [Tribolium castaneum]>gi|270003079|gb|EEZ99526.1| hypothetical protein TcasGA2_TC000108 [Tribolium castaneum] 751798243 XM_011210726.1 68 7.00878e-24 PREDICTED: Bactrocera dorsalis protein furry-like (LOC105230123), mRNA -- -- -- -- O94915 4766 0.0e+00 Protein furry homolog-like OS=Homo sapiens GN=FRYL PE=1 SV=2 PF09201//PF02140//PF05510 SRX, signal recognition particle receptor alpha subunit//Galactose binding lectin domain//Sarcoglycan alpha/epsilon -- -- GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0016012 sarcoglycan complex KOG1825 Fry-like conserved proteins Cluster-8309.38912 BP_3 1030.60 17.21 3178 91084907 XP_969916.1 3665 0.0e+00 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 327 2.39874e-168 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q6GNL7 2853 0.0e+00 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus laevis GN=aldh1l1 PE=2 SV=1 PF02911//PF00551//PF00171 Formyl transferase, C-terminal domain//Formyl transferase//Aldehyde dehydrogenase family GO:0008152//GO:0032259//GO:0055114//GO:0009058 metabolic process//methylation//oxidation-reduction process//biosynthetic process GO:0016491//GO:0008168//GO:0016742//GO:0016620 oxidoreductase activity//methyltransferase activity//hydroxymethyl-, formyl- and related transferase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.38913 BP_3 64.30 0.79 4236 91078850 XP_971848.1 1166 1.7e-124 PREDICTED: uncharacterized protein LOC660531 [Tribolium castaneum]>gi|270004130|gb|EFA00578.1| hypothetical protein TcasGA2_TC003448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03604 DNA directed RNA polymerase, 7 kDa subunit GO:0042318//GO:0006144//GO:0006206//GO:0006351 penicillin biosynthetic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.38914 BP_3 2940.77 81.03 2041 642923787 XP_008193883.1 1066 3.3e-113 PREDICTED: uncharacterized protein F13E6.1 [Tribolium castaneum]>gi|642923789|ref|XP_008193884.1| PREDICTED: uncharacterized protein F13E6.1 [Tribolium castaneum]>gi|270006945|gb|EFA03393.1| hypothetical protein TcasGA2_TC013379 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55326 188 8.7e-13 Uncharacterized protein F13E6.1 OS=Caenorhabditis elegans GN=F13E6.1 PE=3 SV=2 PF10392 Golgi transport complex subunit 5 GO:0006891 intra-Golgi vesicle-mediated transport -- -- GO:0017119 Golgi transport complex KOG4010 Coiled-coil protein TPD52 Cluster-8309.38916 BP_3 561.40 27.89 1262 642936197 XP_008198342.1 1125 2.9e-120 PREDICTED: syntaxin 1A isoform X1 [Tribolium castaneum] 820846578 XM_012485781.1 273 9.77669e-139 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X1, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 999 4.9e-107 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF02601//PF00015//PF04136//PF01499//PF08245//PF09177//PF05739//PF06667//PF00804//PF02346//PF01496//PF04632//PF02485//PF06009 Exonuclease VII, large subunit//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family//Herpesvirus UL25 family//Mur ligase middle domain//Syntaxin 6, N-terminal//SNARE domain//Phage shock protein B//Syntaxin//Chordopoxvirus multifunctional envelope protein A27//V-type ATPase 116kDa subunit family//Fusaric acid resistance protein family//Core-2/I-Branching enzyme//Laminin Domain II GO:0009271//GO:0019072//GO:0007165//GO:0006810//GO:0006886//GO:0006355//GO:0009058//GO:0015992//GO:0048193//GO:0019064//GO:0015991//GO:0007155//GO:0006308 phage shock//viral genome packaging//signal transduction//transport//intracellular protein transport//regulation of transcription, DNA-templated//biosynthetic process//proton transport//Golgi vesicle transport//fusion of virus membrane with host plasma membrane//ATP hydrolysis coupled proton transport//cell adhesion//DNA catabolic process GO:0005524//GO:0008375//GO:0015078//GO:0005515//GO:0008855//GO:0004871 ATP binding//acetylglucosaminyltransferase activity//hydrogen ion transmembrane transporter activity//protein binding//exodeoxyribonuclease VII activity//signal transducer activity GO:0042025//GO:0005801//GO:0009318//GO:0005886//GO:0019031//GO:0016020//GO:0033179 host cell nucleus//cis-Golgi network//exodeoxyribonuclease VII complex//plasma membrane//viral envelope//membrane//proton-transporting V-type ATPase, V0 domain KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.38917 BP_3 239.75 9.60 1496 642936197 XP_008198342.1 930 1.4e-97 PREDICTED: syntaxin 1A isoform X1 [Tribolium castaneum] 820846582 XM_012485783.1 230 9.32322e-115 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X3, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 818 5.6e-86 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF00804//PF01496//PF04632//PF02485//PF02601//PF04136//PF01499//PF08245//PF00745//PF09177 Syntaxin//V-type ATPase 116kDa subunit family//Fusaric acid resistance protein family//Core-2/I-Branching enzyme//Exonuclease VII, large subunit//Sec34-like family//Herpesvirus UL25 family//Mur ligase middle domain//Glutamyl-tRNAGlu reductase, dimerisation domain//Syntaxin 6, N-terminal GO:0033014//GO:0048193//GO:0015991//GO:0006308//GO:0006810//GO:0006886//GO:0019072//GO:0015992//GO:0055114//GO:0009058 tetrapyrrole biosynthetic process//Golgi vesicle transport//ATP hydrolysis coupled proton transport//DNA catabolic process//transport//intracellular protein transport//viral genome packaging//proton transport//oxidation-reduction process//biosynthetic process GO:0008855//GO:0050661//GO:0008375//GO:0005524//GO:0008883//GO:0015078 exodeoxyribonuclease VII activity//NADP binding//acetylglucosaminyltransferase activity//ATP binding//glutamyl-tRNA reductase activity//hydrogen ion transmembrane transporter activity GO:0005886//GO:0033179//GO:0016020//GO:0042025//GO:0009318//GO:0005801 plasma membrane//proton-transporting V-type ATPase, V0 domain//membrane//host cell nucleus//exodeoxyribonuclease VII complex//cis-Golgi network KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.38918 BP_3 1226.45 6.93 8819 270014238 EFA10686.1 640 3.5e-63 Syntaxin 1A [Tribolium castaneum] 820846584 XM_012485784.1 129 7.83117e-58 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X4, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 565 7.2e-56 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF04111//PF07851//PF02485//PF05478//PF04632//PF00443//PF00804//PF11744//PF09177//PF05739//PF09003//PF01499//PF04799//PF04136//PF15898 Autophagy protein Apg6//TMPIT-like protein//Core-2/I-Branching enzyme//Prominin//Fusaric acid resistance protein family//Ubiquitin carboxyl-terminal hydrolase//Syntaxin//Aluminium activated malate transporter//Syntaxin 6, N-terminal//SNARE domain//Bacteriophage lambda integrase, N-terminal domain//Herpesvirus UL25 family//fzo-like conserved region//Sec34-like family//cGMP-dependent protein kinase interacting domain GO:0048193//GO:0015743//GO:0015074//GO:0008053//GO:0006886//GO:0006810//GO:0006914//GO:0019072//GO:0016579 Golgi vesicle transport//malate transport//DNA integration//mitochondrial fusion//intracellular protein transport//transport//autophagy//viral genome packaging//protein deubiquitination GO:0005515//GO:0003677//GO:0008907//GO:0008375//GO:0003924//GO:0036459//GO:0019901 protein binding//DNA binding//integrase activity//acetylglucosaminyltransferase activity//GTPase activity//ubiquitinyl hydrolase activity//protein kinase binding GO:0005886//GO:0016020//GO:0005741//GO:0042025//GO:0016021//GO:0005801 plasma membrane//membrane//mitochondrial outer membrane//host cell nucleus//integral component of membrane//cis-Golgi network KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.38919 BP_3 876.68 10.86 4183 642920663 XP_008192510.1 195 6.6e-12 PREDICTED: tropomyosin-1, isoforms 33/34 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36188 159 4.1e-09 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF00832 Troponin//Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0005861 intracellular//ribosome//troponin complex -- -- Cluster-8309.38920 BP_3 55.00 2.78 1246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38921 BP_3 943.41 19.86 2581 270005574 EFA02022.1 1711 6.7e-188 hypothetical protein TcasGA2_TC007647 [Tribolium castaneum] 642919114 XM_008193522.1 141 4.84843e-65 PREDICTED: Tribolium castaneum DDB1- and CUL4-associated factor 8 (LOC656756), mRNA K11804 WDR42A WD repeat-containing protein 42A http://www.genome.jp/dbget-bin/www_bget?ko:K11804 Q5TAQ9 992 6.5e-106 DDB1- and CUL4-associated factor 8 OS=Homo sapiens GN=DCAF8 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1334 WD40 repeat protein Cluster-8309.38923 BP_3 455.00 4.38 5294 607362451 EZA56703.1 148 2.4e-06 hypothetical protein X777_02307, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38924 BP_3 576.20 9.65 3170 642939241 XP_008194774.1 1673 2.1e-183 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q7TSX5 732 1.1e-75 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Rattus norvegicus GN=Sgms1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.38925 BP_3 413.31 4.20 5036 642930595 XP_001807608.2 1912 6.4e-211 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00240//PF03091 Ubiquitin family//CutA1 divalent ion tolerance protein GO:0010038 response to metal ion GO:0005515 protein binding -- -- -- -- Cluster-8309.38928 BP_3 485.48 2.28 10542 270003689 EFA00137.1 2104 7.3e-233 hypothetical protein TcasGA2_TC002957 [Tribolium castaneum] 642916224 XM_008192715.1 305 1.36072e-155 PREDICTED: Tribolium castaneum uncharacterized LOC662985 (LOC662985), mRNA -- -- -- -- Q9BXF3 437 6.0e-41 Cat eye syndrome critical region protein 2 OS=Homo sapiens GN=CECR2 PE=1 SV=2 PF02459//PF00067//PF00631//PF00439 Adenoviral DNA terminal protein//Cytochrome P450//GGL domain//Bromodomain GO:0007165//GO:0055114//GO:0007186//GO:0006260 signal transduction//oxidation-reduction process//G-protein coupled receptor signaling pathway//DNA replication GO:0005515//GO:0016705//GO:0003677//GO:0020037//GO:0005506//GO:0004871 protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//DNA binding//heme binding//iron ion binding//signal transducer activity GO:0005834 heterotrimeric G-protein complex -- -- Cluster-8309.38929 BP_3 42.55 0.46 4723 642912869 XP_008201289.1 3556 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X6 [Tribolium castaneum] 642912868 XM_008203067.1 827 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X6, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1296 6.6e-141 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00076//PF00781//PF00609//PF00788 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase catalytic domain//Diacylglycerol kinase accessory domain//Ras association (RalGDS/AF-6) domain GO:0046486//GO:0007165//GO:0007205//GO:0009395 glycerolipid metabolic process//signal transduction//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process GO:0004143//GO:0016301//GO:0003676 diacylglycerol kinase activity//kinase activity//nucleic acid binding -- -- -- -- Cluster-8309.3893 BP_3 8.00 0.55 997 15420657 AAK97411.1 449 5.6e-42 serine protease-like protein [Anthonomus grandis] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q17004 323 9.3e-29 Serine protease SP24D OS=Anopheles gambiae GN=Sp24D PE=2 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38930 BP_3 1562.79 6.87 11255 642934739 XP_008197793.1 2939 0.0e+00 PREDICTED: uncharacterized protein LOC658527 [Tribolium castaneum] 462321141 APGK01043373.1 66 1.05113e-22 Dendroctonus ponderosae Seq01043383, whole genome shotgun sequence K11984 SART1, HAF, SNU66 U4/U6.U5 tri-snRNP-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11984 O43290 908 1.5e-95 U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens GN=SART1 PE=1 SV=1 PF00856//PF00569//PF03412//PF07496//PF03343//PF00628//PF01033 SET domain//Zinc finger, ZZ type//Peptidase C39 family//CW-type Zinc Finger//SART-1 family//PHD-finger//Somatomedin B domain GO:0007165//GO:0006955//GO:0006508//GO:0000398 signal transduction//immune response//proteolysis//mRNA splicing, via spliceosome GO:0005044//GO:0005524//GO:0005515//GO:0030247//GO:0008270//GO:0008233 scavenger receptor activity//ATP binding//protein binding//polysaccharide binding//zinc ion binding//peptidase activity GO:0016021 integral component of membrane KOG2217 U4/U6.U5 snRNP associated protein Cluster-8309.38932 BP_3 35.75 0.59 3219 478251374 ENN71840.1 3367 0.0e+00 hypothetical protein YQE_11459, partial [Dendroctonus ponderosae] 642926047 XM_964823.2 392 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2583 2.6e-290 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain GO:0008152//GO:0055114//GO:0009058 metabolic process//oxidation-reduction process//biosynthetic process GO:0016742//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.38933 BP_3 30.00 0.70 2362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38934 BP_3 6.00 1.05 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38935 BP_3 48.00 5.09 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38936 BP_3 12.98 0.35 2096 189237983 XP_001814292.1 704 3.2e-71 PREDICTED: filaggrin-2 [Tribolium castaneum]>gi|270006655|gb|EFA03103.1| hypothetical protein TcasGA2_TC013013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82120 156 4.6e-09 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.38937 BP_3 260.60 4.20 3283 91090882 XP_973170.1 768 1.9e-78 PREDICTED: death-associated protein kinase related [Tribolium castaneum] -- -- -- -- -- K08804 STK17 serine/threonine kinase 17 http://www.genome.jp/dbget-bin/www_bget?ko:K08804 Q0KHT7 435 3.2e-41 Death-associated protein kinase related OS=Drosophila melanogaster GN=Drak PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.38939 BP_3 488.67 8.56 3044 642918139 XP_008191383.1 1080 1.2e-114 PREDICTED: hepatic leukemia factor-like, partial [Tribolium castaneum] 642918138 XM_008193161.1 286 1.42177e-145 PREDICTED: Tribolium castaneum hepatic leukemia factor-like (LOC655431), partial mRNA K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q64709 422 9.5e-40 Hepatic leukemia factor OS=Rattus norvegicus GN=Hlf PE=2 SV=1 PF09726//PF03131//PF07716//PF00170 Transmembrane protein//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.3894 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38940 BP_3 249.56 3.83 3435 642924682 XP_008194395.1 1811 2.2e-199 PREDICTED: voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [Tribolium castaneum] 642924681 XM_008196173.1 612 0 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X4, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 1236 4.4e-134 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF00018//PF01424//PF12052//PF08437 SH3 domain//R3H domain//Voltage gated calcium channel subunit beta domain 4Aa N terminal//Glycosyl transferase family 8 C-terminal GO:0006816//GO:0009103//GO:0070588 calcium ion transport//lipopolysaccharide biosynthetic process//calcium ion transmembrane transport GO:0003676//GO:0008918//GO:0005245//GO:0005515 nucleic acid binding//lipopolysaccharide 3-alpha-galactosyltransferase activity//voltage-gated calcium channel activity//protein binding GO:0005891 voltage-gated calcium channel complex KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.38941 BP_3 2603.00 62.60 2296 -- -- -- -- -- 642926067 XM_008196530.1 61 1.27585e-20 PREDICTED: Tribolium castaneum calsyntenin-1 (LOC659467), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38943 BP_3 692.00 56.41 883 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08513 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38945 BP_3 918.65 11.32 4202 642932431 XP_008197110.1 2076 5.1e-230 PREDICTED: uncharacterized protein LOC100141760 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38947 BP_3 1653.97 19.21 4441 91086115 XP_968072.1 1323 1.1e-142 PREDICTED: sister chromatid cohesion protein DCC1 [Tribolium castaneum] -- -- -- -- -- K11271 DSCC1, DCC1 sister chromatid cohesion protein DCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K11271 Q6GMB0 633 4.7e-64 Sister chromatid cohesion protein DCC1 OS=Xenopus laevis GN=dscc1 PE=2 SV=1 PF00018//PF14604//PF04421//PF04088 SH3 domain//Variant SH3 domain//Mss4 protein//Peroxin 13, N-terminal region GO:0007264//GO:0016560//GO:0043087 small GTPase mediated signal transduction//protein import into peroxisome matrix, docking//regulation of GTPase activity GO:0005515//GO:0005085 protein binding//guanyl-nucleotide exchange factor activity GO:0005777//GO:0016021 peroxisome//integral component of membrane KOG3875 Peroxisomal biogenesis protein peroxin Cluster-8309.38949 BP_3 251.99 18.48 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38950 BP_3 63.30 0.67 4834 642914654 XP_008190301.1 1656 3.0e-181 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.87333e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.3e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.38951 BP_3 2460.62 32.54 3937 642914454 XP_008201683.1 669 6.8e-67 PREDICTED: proteoglycan 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38953 BP_3 131.45 1.87 3688 91084663 XP_967750.1 1183 1.6e-126 PREDICTED: ubiquitin carboxyl-terminal hydrolase 4 isoform X1 [Tribolium castaneum]>gi|270008628|gb|EFA05076.1| hypothetical protein TcasGA2_TC015173 [Tribolium castaneum] 698430595 XM_009698856.1 46 4.49103e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K11833 USP2_21 ubiquitin carboxyl-terminal hydrolase 2/21 http://www.genome.jp/dbget-bin/www_bget?ko:K11833 Q2KHV7 778 6.0e-81 Ubiquitin carboxyl-terminal hydrolase 2 OS=Bos taurus GN=USP2 PE=2 SV=1 PF05427//PF00443//PF15957//PF12422 Acidic fibroblast growth factor binding (FIBP)//Ubiquitin carboxyl-terminal hydrolase//Commissureless//Condensin II non structural maintenance of chromosomes subunit GO:0006508//GO:0007411//GO:0016579 proteolysis//axon guidance//protein deubiquitination GO:0017134//GO:0036459//GO:0008233 fibroblast growth factor binding//ubiquitinyl hydrolase activity//peptidase activity GO:0005634 nucleus -- -- Cluster-8309.38955 BP_3 194.63 1.57 6280 815769352 XP_012234789.1 1736 2.0e-190 PREDICTED: synaptotagmin-7 isoform X1 [Linepithema humile]>gi|815769354|ref|XP_012234790.1| PREDICTED: synaptotagmin-7 isoform X1 [Linepithema humile] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 870 2.2e-91 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF04545//PF10176//PF00168 Sigma-70, region 4//Protein of unknown function (DUF2370)//C2 domain GO:0006352//GO:0007034//GO:0006355//GO:0030001 DNA-templated transcription, initiation//vacuolar transport//regulation of transcription, DNA-templated//metal ion transport GO:0003700//GO:0016987//GO:0005515//GO:0003677 transcription factor activity, sequence-specific DNA binding//sigma factor activity//protein binding//DNA binding GO:0005667 transcription factor complex KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.38957 BP_3 2918.92 116.44 1500 91083015 XP_974607.1 1130 9.1e-121 PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|642923430|ref|XP_008193741.1| PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|270007020|gb|EFA03468.1| hypothetical protein TcasGA2_TC013464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RCA6 368 8.5e-34 Clavesin-1 OS=Pongo abelii GN=CLVS1 PE=2 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.38958 BP_3 1731.24 84.61 1278 642915807 XP_008200086.1 1678 2.2e-184 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 766926462 XM_011496875.1 210 1.0407e-103 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- Q8CGF6 945 9.0e-101 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.38959 BP_3 110.30 4.75 1410 270003147 EEZ99594.1 759 8.9e-78 hypothetical protein TcasGA2_TC001581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38961 BP_3 30.59 0.33 4800 642935897 XP_008198219.1 821 2.0e-84 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X2 [Tribolium castaneum] 688627348 LL261331.1 76 1.23276e-28 Echinostoma caproni genome assembly E_caproni_Egypt ,scaffold ECPE_scaffold0027233 -- -- -- -- Q7ZU92 211 4.4e-15 Poly(A)-specific ribonuclease PARN OS=Danio rerio GN=parn PE=1 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.38962 BP_3 221.82 2.93 3936 642927864 XP_008195430.1 2738 8.3e-307 PREDICTED: inhibitor of Bruton tyrosine kinase [Tribolium castaneum]>gi|270010253|gb|EFA06701.1| hypothetical protein TcasGA2_TC009632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPR6 1277 8.8e-139 Inhibitor of Bruton tyrosine kinase OS=Mus musculus GN=Ibtk PE=1 SV=3 PF13606//PF05224//PF00023//PF00651 Ankyrin repeat//NDT80 / PhoG like DNA-binding family//Ankyrin repeat//BTB/POZ domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0783 Uncharacterized conserved protein, contains ankyrin and BTB/POZ domains Cluster-8309.38963 BP_3 155.10 0.95 8192 478257334 ENN77494.1 5217 0.0e+00 hypothetical protein YQE_06020, partial [Dendroctonus ponderosae] 698415894 XM_009696085.1 54 3.58037e-16 PREDICTED: Cariama cristata RAB6A GEF complex partner 1 (RIC1), partial mRNA -- -- -- -- Q9V3C5 2693 1.2e-302 Guanine nucleotide exchange factor subunit Rich OS=Drosophila melanogaster GN=Rich PE=1 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG2006 WD40 repeat protein Cluster-8309.38966 BP_3 7598.00 592.33 910 -- -- -- -- -- 642939846 XM_008195582.1 87 1.74108e-35 PREDICTED: Tribolium castaneum pupal cuticle protein G1A-like (LOC103312114), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38967 BP_3 1600.00 245.35 606 91081977 XP_968285.1 557 1.0e-54 PREDICTED: ATP synthase subunit delta, mitochondrial [Tribolium castaneum]>gi|270008191|gb|EFA04639.1| hypothetical protein TcasGA2_TC013931 [Tribolium castaneum] -- -- -- -- -- K02134 ATPeF1D, ATP5D, ATP16 F-type H+-transporting ATPase subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K02134 Q9D3D9 339 8.0e-31 ATP synthase subunit delta, mitochondrial OS=Mus musculus GN=Atp5d PE=1 SV=1 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1758 Mitochondrial F1F0-ATP synthase, subunit delta/ATP16 Cluster-8309.38971 BP_3 5961.57 34.67 8579 642923487 XP_008193531.1 372 4.1e-32 PREDICTED: RNA binding protein fox-1 homolog 3 isoform X3 [Tribolium castaneum] 642923486 XM_008195309.1 339 1.39135e-174 PREDICTED: Tribolium castaneum RNA binding protein fox-1 homolog 3 (LOC655682), transcript variant X3, mRNA K14946 RBFOX, FOX RNA binding protein fox-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14946 Q9NWB1 148 1.6e-07 RNA binding protein fox-1 homolog 1 OS=Homo sapiens GN=RBFOX1 PE=1 SV=2 PF00076//PF04117 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Mpv17 / PMP22 family -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.38972 BP_3 80.29 0.52 7677 642912688 XP_008200962.1 1566 1.3e-170 PREDICTED: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1 [Tribolium castaneum]>gi|270002375|gb|EEZ98822.1| hypothetical protein TcasGA2_TC004428 [Tribolium castaneum] -- -- -- -- -- K03544 clpX, CLPX ATP-dependent Clp protease ATP-binding subunit ClpX http://www.genome.jp/dbget-bin/www_bget?ko:K03544 Q5U2U0 1223 3.1e-132 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Rattus norvegicus GN=Clpx PE=2 SV=1 PF00437//PF07724//PF14532//PF05496//PF06068//PF00270//PF01096//PF10662//PF00005//PF04851//PF00004//PF01695//PF07728//PF01057//PF00158//PF00503//PF02562//PF02367 Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//DEAD/DEAH box helicase//Transcription factor S-II (TFIIS)//Ethanolamine utilisation - propanediol utilisation//ABC transporter//Type III restriction enzyme, res subunit//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//G-protein alpha subunit//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006457//GO:0006351//GO:0006576//GO:0006310//GO:0002949//GO:0006281//GO:0006810//GO:0019079//GO:0007165//GO:0007186//GO:0006355 protein folding//transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification//DNA repair//transport//viral genome replication//signal transduction//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated GO:0003677//GO:0003678//GO:0017111//GO:0009378//GO:0004871//GO:0003676//GO:0003924//GO:0008134//GO:0016787//GO:0031683//GO:0005524//GO:0016887//GO:0019001//GO:0051082//GO:0008270 DNA binding//DNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//signal transducer activity//nucleic acid binding//GTPase activity//transcription factor binding//hydrolase activity//G-protein beta/gamma-subunit complex binding//ATP binding//ATPase activity//guanyl nucleotide binding//unfolded protein binding//zinc ion binding GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0745 Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) Cluster-8309.38973 BP_3 35.77 0.42 4393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38975 BP_3 12231.68 115.32 5404 642932918 XP_008197187.1 5621 0.0e+00 PREDICTED: uncharacterized protein LOC656619 [Tribolium castaneum] 642932917 XM_008198965.1 278 7.10458e-141 PREDICTED: Tribolium castaneum uncharacterized LOC656619 (LOC656619), mRNA K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q3UQ28 971 3.7e-103 Peroxidasin homolog OS=Mus musculus GN=Pxdn PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.38978 BP_3 611.60 15.56 2186 270014320 EFA10768.1 2315 5.2e-258 dunce [Tribolium castaneum] 642935593 XM_008199853.1 759 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X15, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 1813 3.4e-201 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.38979 BP_3 18.13 0.38 2573 195490337 XP_002093097.1 297 6.1e-24 GE21136 [Drosophila yakuba]>gi|194179198|gb|EDW92809.1| GE21136 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- P82596 195 1.7e-13 Perlucin OS=Haliotis laevigata PE=1 SV=3 PF07740//PF02944 Ion channel inhibitory toxin//BESS motif GO:0006810//GO:0009405 transport//pathogenesis GO:0008200//GO:0003677 ion channel inhibitor activity//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.38980 BP_3 2703.61 32.06 4356 270008438 EFA04886.1 1526 3.2e-166 hypothetical protein TcasGA2_TC014948 [Tribolium castaneum] 817062635 XM_012397559.1 107 6.54013e-46 PREDICTED: Athalia rosae arginine-glutamic acid dipeptide repeats protein (LOC105684303), transcript variant X4, mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q9P2R6 679 2.1e-69 Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens GN=RERE PE=1 SV=2 PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.38981 BP_3 179.73 6.35 1655 91095219 XP_969883.1 687 2.3e-69 PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940081|ref|XP_008192927.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940083|ref|XP_008192931.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|270016019|gb|EFA12467.1| hypothetical protein TcasGA2_TC010611 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q765P3 534 5.3e-53 Peptidoglycan-recognition protein 2 OS=Holotrichia diomphalia GN=PGRP-2 PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009252//GO:0009253//GO:0006807 peptidoglycan biosynthetic process//peptidoglycan catabolic process//nitrogen compound metabolic process GO:0008270//GO:0008745 zinc ion binding//N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.38982 BP_3 365.93 7.36 2689 642912272 XP_008200632.1 704 4.1e-71 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 6.7e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF15965//PF01414//PF00089 TRAF-like zinc-finger//Delta serrate ligand//Trypsin GO:0006508//GO:0007154 proteolysis//cell communication GO:0008270//GO:0004252 zinc ion binding//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.38984 BP_3 2114.74 74.39 1662 282158103 NP_001164095.1 1660 3.5e-182 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.8127e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1365 2.3e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF04851//PF03141 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//Putative S-adenosyl-L-methionine-dependent methyltransferase -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524//GO:0008168 nucleic acid binding//hydrolase activity//DNA binding//ATP binding//methyltransferase activity -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.38985 BP_3 156.49 0.88 8869 646710408 KDR15927.1 1192 3.5e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.71491e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 PF11561 Single strand annealing-weakened 1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends GO:0070336 flap-structured DNA binding -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.38986 BP_3 55.36 2.34 1430 669274418 XP_008629343.1 357 3.7e-31 PREDICTED: polyubiquitin-B isoform X7 [Corvus brachyrhynchos] 69608590 AM040016.1 261 5.20816e-132 Timarcha balearica mRNA for ubiquitin/ribosomal protein S27Ae fusion protein (ubq/S27Ae gene) K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 P0CG60 351 7.6e-32 Polyubiquitin-B OS=Pongo pygmaeus GN=UBB PE=3 SV=1 PF06305//PF00240//PF14560//PF01599 Protein of unknown function (DUF1049)//Ubiquitin family//Ubiquitin-like domain//Ribosomal protein S27a GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005887//GO:0005840 integral component of plasma membrane//ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.38987 BP_3 8.36 0.39 1338 357611230 EHJ67381.1 181 8.9e-11 hypothetical protein KGM_13834 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38988 BP_3 1242.65 7.57 8209 270001102 EEZ97549.1 1832 2.0e-201 hypothetical protein TcasGA2_TC011399 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZW4 179 3.8e-11 Dentin sialophosphoprotein OS=Homo sapiens GN=DSPP PE=1 SV=2 PF03931//PF04433 Skp1 family, tetramerisation domain//SWIRM domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- -- -- Cluster-8309.38990 BP_3 162.78 2.39 3576 642936594 XP_008198499.1 1421 3.9e-154 PREDICTED: solute carrier family 2, facilitated glucose transporter member 1-like isoform X2 [Tribolium castaneum]>gi|270014149|gb|EFA10597.1| hypothetical protein TcasGA2_TC012857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13355 670 1.9e-68 Solute carrier family 2, facilitated glucose transporter member 1 OS=Oryctolagus cuniculus GN=SLC2A1 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38991 BP_3 708.99 21.49 1882 170321837 BAG14263.1 925 6.7e-97 GNBP1 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- O96363 566 1.2e-56 Beta-1,3-glucan-binding protein (Fragment) OS=Hyphantria cunea GN=gnbp1 PE=2 SV=1 PF15886//PF00722//PF10584 Carbohydrate binding domain (family 32)//Glycosyl hydrolases family 16//Proteasome subunit A N-terminal signature GO:0005975//GO:0006511 carbohydrate metabolic process//ubiquitin-dependent protein catabolic process GO:0004175//GO:0004553//GO:0030246 endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding GO:0019773 proteasome core complex, alpha-subunit complex -- -- Cluster-8309.38994 BP_3 68.72 1.02 3525 546673138 ERL84803.1 1914 2.6e-211 hypothetical protein D910_02228 [Dendroctonus ponderosae] 645036531 XM_001607427.3 100 4.11227e-42 PREDICTED: Nasonia vitripennis ribulose-phosphate 3-epimerase (LOC100121800), mRNA K01937 pyrG, CTPS CTP synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01937 Q2M197 1464 1.6e-160 CTP synthase OS=Drosophila pseudoobscura pseudoobscura GN=CTPsyn PE=3 SV=2 PF00834//PF01729//PF16941//PF06418//PF00215 Ribulose-phosphate 3 epimerase family//Quinolinate phosphoribosyl transferase, C-terminal domain//Putative cyclodextrin porin//CTP synthase N-terminus//Orotidine 5'-phosphate decarboxylase / HUMPS family GO:0006206//GO:0009435//GO:0005975//GO:0098657//GO:0006207//GO:0006221//GO:0046497 pyrimidine nucleobase metabolic process//NAD biosynthetic process//carbohydrate metabolic process//import into cell//'de novo' pyrimidine nucleobase biosynthetic process//pyrimidine nucleotide biosynthetic process//nicotinate nucleotide metabolic process GO:0004590//GO:0004514//GO:0016857//GO:0003883 orotidine-5'-phosphate decarboxylase activity//nicotinate-nucleotide diphosphorylase (carboxylating) activity//racemase and epimerase activity, acting on carbohydrates and derivatives//CTP synthase activity -- -- KOG2387 CTP synthase (UTP-ammonia lyase) Cluster-8309.38996 BP_3 89.19 1.37 3434 642921494 XP_968130.3 2423 2.4e-270 PREDICTED: uncharacterized protein LOC656511 [Tribolium castaneum]>gi|270006226|gb|EFA02674.1| hypothetical protein TcasGA2_TC008395 [Tribolium castaneum] 642921493 XM_963037.3 221 2.18311e-109 PREDICTED: Tribolium castaneum uncharacterized LOC656511 (LOC656511), mRNA -- -- -- -- O43182 480 2.0e-46 Rho GTPase-activating protein 6 OS=Homo sapiens GN=ARHGAP6 PE=1 SV=3 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG2710 Rho GTPase-activating protein Cluster-8309.38997 BP_3 1117.90 23.60 2575 571330970 AHF27417.1 1710 8.7e-188 putative sugar transporter 4_1 [Phaedon cochleariae] 195586810 XM_002083125.1 43 1.45371e-10 Drosophila simulans GD13586 (Dsim\GD13586), mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 P20303 942 4.0e-100 Solute carrier family 2, facilitated glucose transporter member 1 OS=Sus scrofa GN=SLC2A1 PE=2 SV=2 PF00083//PF08157//PF07690 Sugar (and other) transporter//NUC129 domain//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0569 Permease of the major facilitator superfamily Cluster-8309.38999 BP_3 1.14 22.75 226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11734 TilS substrate C-terminal domain GO:0008033 tRNA processing GO:0005524//GO:0000166//GO:0016879 ATP binding//nucleotide binding//ligase activity, forming carbon-nitrogen bonds GO:0005737 cytoplasm -- -- Cluster-8309.39 BP_3 132.62 5.26 1508 815896315 XP_012246840.1 705 1.7e-71 PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896317|ref|XP_012246847.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896319|ref|XP_012246857.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q9WUW9 404 5.7e-38 Sulfotransferase 1C2A OS=Rattus norvegicus GN=Sult1c2a PE=2 SV=2 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.390 BP_3 7.00 1.06 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39000 BP_3 14.84 0.98 1019 270004579 EFA01027.1 154 9.2e-08 hypothetical protein TcasGA2_TC003942 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39002 BP_3 15.49 0.31 2686 478257818 ENN77961.1 729 5.1e-74 hypothetical protein YQE_05638, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39003 BP_3 130.91 1.00 6620 642931206 XP_008196483.1 165 3.2e-08 PREDICTED: WD repeat domain phosphoinositide-interacting protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39005 BP_3 873.27 11.53 3943 189241935 XP_969741.2 2165 2.3e-240 PREDICTED: coronin-2B-like isoform X2 [Tribolium castaneum] 612001587 XM_007485717.1 39 3.74057e-08 PREDICTED: Monodelphis domestica coronin 6 (CORO6), transcript variant X3, mRNA K13887 CORO2 coronin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13887 A8WGE3 1310 1.3e-142 Coronin-2B OS=Xenopus tropicalis GN=coro2b PE=2 SV=1 PF04977//PF00400 Septum formation initiator//WD domain, G-beta repeat GO:0007049 cell cycle GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.39006 BP_3 862.00 8.69 5072 189236774 XP_001807993.1 1012 1.5e-106 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 2 [Tribolium castaneum]>gi|270006213|gb|EFA02661.1| hypothetical protein TcasGA2_TC008382 [Tribolium castaneum] -- -- -- -- -- K15425 PPP4R2 serine/threonine-protein phosphatase 4 regulatory subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15425 Q9W2U4 502 8.4e-49 Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Drosophila melanogaster GN=PPP4R2r PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3175 Protein phosphatase 4 regulatory subunit 2 related protein Cluster-8309.39007 BP_3 278.80 1.46 9482 91092856 XP_969290.1 11440 0.0e+00 PREDICTED: protein furry [Tribolium castaneum]>gi|270003079|gb|EEZ99526.1| hypothetical protein TcasGA2_TC000108 [Tribolium castaneum] 751798243 XM_011210726.1 68 6.84146e-24 PREDICTED: Bactrocera dorsalis protein furry-like (LOC105230123), mRNA -- -- -- -- O94915 4766 0.0e+00 Protein furry homolog-like OS=Homo sapiens GN=FRYL PE=1 SV=2 PF02140//PF05510 Galactose binding lectin domain//Sarcoglycan alpha/epsilon -- -- GO:0030246 carbohydrate binding GO:0016012 sarcoglycan complex KOG1825 Fry-like conserved proteins Cluster-8309.39010 BP_3 211.21 4.27 2674 642935588 XP_008198072.1 3009 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform M isoform X10 [Tribolium castaneum] 642935587 XM_008199850.1 976 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X12, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 2360 1.6e-264 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF07469//PF00233//PF00104 Domain of unknown function (DUF1518)//3'5'-cyclic nucleotide phosphodiesterase//Ligand-binding domain of nuclear hormone receptor GO:0006144//GO:0007165//GO:0043401//GO:0006355 purine nucleobase metabolic process//signal transduction//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.39011 BP_3 440.61 4.07 5511 642916459 XP_008191036.1 2630 3.9e-294 PREDICTED: sestrin homolog [Tribolium castaneum]>gi|642916461|ref|XP_008191037.1| PREDICTED: sestrin homolog [Tribolium castaneum] 642916460 XM_008192815.1 596 0 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 P58006 1113 1.3e-119 Sestrin-1 OS=Mus musculus GN=Sesn1 PE=2 SV=3 PF04636 PA26 p53-induced protein (sestrin) GO:1901031 regulation of response to reactive oxygen species -- -- GO:0005634 nucleus KOG3746 Uncharacterized conserved protein Cluster-8309.39013 BP_3 698.77 8.35 4326 642919644 XP_008192004.1 1576 5.0e-172 PREDICTED: fatty acid hydroxylase domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07750 E1.14.13.72, SC4MOL, ERG25 methylsterol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K07750 Q9GKT2 894 2.5e-94 Fatty acid hydroxylase domain-containing protein 2 OS=Macaca fascicularis GN=FAXDC2 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0055114//GO:0006633 oxidation-reduction process//fatty acid biosynthetic process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- KOG0873 C-4 sterol methyl oxidase Cluster-8309.39014 BP_3 2045.90 25.72 4126 91080745 XP_966455.1 1586 3.3e-173 PREDICTED: fatty acid hydroxylase domain-containing protein 2 isoform X1 [Tribolium castaneum]>gi|270005453|gb|EFA01901.1| hypothetical protein TcasGA2_TC007511 [Tribolium castaneum] -- -- -- -- -- K07750 E1.14.13.72, SC4MOL, ERG25 methylsterol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K07750 Q9GKT2 894 2.4e-94 Fatty acid hydroxylase domain-containing protein 2 OS=Macaca fascicularis GN=FAXDC2 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0005506//GO:0016491 iron ion binding//oxidoreductase activity GO:0016021 integral component of membrane KOG0873 C-4 sterol methyl oxidase Cluster-8309.39016 BP_3 3065.79 32.06 4901 24646906 NP_731941.1 804 1.9e-82 effete, isoform A [Drosophila melanogaster]>gi|187117170|ref|NP_001119686.1| effete [Acyrthosiphon pisum]>gi|442619106|ref|NP_001262578.1| effete, isoform B [Drosophila melanogaster]>gi|442619108|ref|NP_001262579.1| effete, isoform C [Drosophila melanogaster]>gi|58381090|ref|XP_310998.2| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|91077526|ref|XP_970430.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Tribolium castaneum]>gi|156550189|ref|XP_001605481.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Nasonia vitripennis]>gi|157134117|ref|XP_001663154.1| AAEL003103-PA [Aedes aegypti]>gi|194743322|ref|XP_001954149.1| GF18131 [Drosophila ananassae]>gi|194900836|ref|XP_001979961.1| GG21088 [Drosophila erecta]>gi|195061220|ref|XP_001995948.1| GH14086 [Drosophila grimshawi]>gi|195113175|ref|XP_002001144.1| GI10619 [Drosophila mojavensis]>gi|195143851|ref|XP_002012910.1| GL23670 [Drosophila persimilis]>gi|195328929|ref|XP_002031164.1| GM25828 [Drosophila sechellia]>gi|195390905|ref|XP_002054107.1| GJ22971 [Drosophila virilis]>gi|195444200|ref|XP_002069759.1| GK11688 [Drosophila willistoni]>gi|195501528|ref|XP_002097834.1| eff [Drosophila yakuba]>gi|195570846|ref|XP_002103415.1| GD20402 [Drosophila simulans]>gi|198451027|ref|XP_002137205.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|498939690|ref|XP_004521259.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|498939696|ref|XP_004521261.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|557775059|ref|XP_005187176.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Musca domestica]>gi|746860060|ref|XP_011060857.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Acromyrmex echinatior]>gi|749733753|ref|XP_011147642.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Harpegnathos saltator]>gi|751469127|ref|XP_011189731.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera cucurbitae]>gi|751776279|ref|XP_011214825.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|751776281|ref|XP_011214826.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|755991226|ref|XP_011312803.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Fopius arisanus]>gi|759038025|ref|XP_011351525.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Cerapachys biroi]>gi|766937511|ref|XP_011501212.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratosolen solmsi marchali]>gi|769846059|ref|XP_011634316.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Pogonomyrmex barbatus]>gi|780635308|ref|XP_011686505.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Wasmannia auropunctata]>gi|795091706|ref|XP_011879556.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Vollenhovia emeryi]>gi|801395562|ref|XP_012058392.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Atta cephalotes]>gi|815791114|ref|XP_012216125.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Linepithema humile]>gi|817074138|ref|XP_012259245.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Athalia rosae]>gi|817201924|ref|XP_012276729.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Orussus abietinus]>gi|826426802|ref|XP_012527496.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Monomorium pharaonis]>gi|136643|sp|P25867.1|UBCD1_DROME RecName: Full=Ubiquitin-conjugating enzyme E2-17 kDa; AltName: Full=Protein effete; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-protein ligase>gi|8783|emb|CAA44453.1| ubiquitin-conjugating enzyme [Drosophila melanogaster]>gi|7299919|gb|AAF55093.1| effete, isoform A [Drosophila melanogaster]>gi|16648156|gb|AAL25343.1| GH14739p [Drosophila melanogaster]>gi|46561756|gb|AAT01083.1| putative ubiquitin-conjugating enzyme [Homalodisca vitripennis]>gi|55243675|gb|EAA06420.3| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|89473748|gb|ABD72686.1| putative ubiquitin-conjugating enzyme [Acyrthosiphon pisum]>gi|94468952|gb|ABF18325.1| ubiquitin-conjugating enzyme [Aedes aegypti]>gi|108881406|gb|EAT45631.1| AAEL003103-PA [Aedes aegypti]>gi|190627186|gb|EDV42710.1| GF18131 [Drosophila ananassae]>gi|190651664|gb|EDV48919.1| GG21088 [Drosophila erecta]>gi|193891740|gb|EDV90606.1| GH14086 [Drosophila grimshawi]>gi|193917738|gb|EDW16605.1| GI10619 [Drosophila mojavensis]>gi|194101853|gb|EDW23896.1| GL23670 [Drosophila persimilis]>gi|194120107|gb|EDW42150.1| GM25828 [Drosophila sechellia]>gi|194152193|gb|EDW67627.1| GJ22971 [Drosophila virilis]>gi|194165844|gb|EDW80745.1| GK11688 [Drosophila willistoni]>gi|194183935|gb|EDW97546.1| eff [Drosophila yakuba]>gi|194199342|gb|EDX12918.1| GD20402 [Drosophila simulans]>gi|198131302|gb|EDY67763.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|220945198|gb|ACL85142.1| eff-PA, partial [synthetic construct]>gi|220955014|gb|ACL90050.1| eff-PA [synthetic construct]>gi|239791033|dbj|BAH72034.1| ACYPI000078 [Acyrthosiphon pisum]>gi|270002752|gb|EEZ99199.1| effete [Tribolium castaneum]>gi|332375666|gb|AEE62974.1| unknown [Dendroctonus ponderosae]>gi|440217433|gb|AGB95959.1| effete, isoform B [Drosophila melanogaster]>gi|440217434|gb|AGB95960.1| effete, isoform C [Drosophila melanogaster]>gi|478262539|gb|ENN81177.1| hypothetical protein YQE_02422, partial [Dendroctonus ponderosae]>gi|546683237|gb|ERL93069.1| hypothetical protein D910_10371 [Dendroctonus ponderosae]>gi|646714335|gb|KDR18345.1| Ubiquitin-conjugating enzyme E2-17 kDa [Zootermopsis nevadensis]>gi|861642908|gb|KMQ94120.1| ubiquitin-conjugating enzyme [Lasius niger]>gi|900914055|gb|KMZ03557.1| uncharacterized protein Dsimw501_GD20402 [Drosophila simulans] 642914089 XM_965337.3 556 0 PREDICTED: Tribolium castaneum effete (LOC658996), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P25867 804 7.7e-84 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=eff PE=2 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0016567//GO:0051276//GO:0007286//GO:0031647//GO:0008054//GO:0007140//GO:0030718//GO:0006464//GO:0045676//GO:0048132//GO:0016322//GO:0015031//GO:0007067 protein ubiquitination//chromosome organization//spermatid development//regulation of protein stability//negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation//male meiosis//germ-line stem cell population maintenance//cellular protein modification process//regulation of R7 cell differentiation//female germ-line stem cell asymmetric division//neuron remodeling//protein transport//mitotic nuclear division GO:0004842//GO:0005515//GO:0005524 ubiquitin-protein transferase activity//protein binding//ATP binding GO:0005875 microtubule associated complex KOG0417 Ubiquitin-protein ligase Cluster-8309.39017 BP_3 357.62 3.96 4645 642926413 XP_008191952.1 2922 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X1 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.37768e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 3.5e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.39018 BP_3 444.50 6.11 3801 572098878 AHF48760.1 2137 3.9e-237 mitochondrial arginyl-tRNA synthetase [Caryedes brasiliensis] 874501526 XM_013108851.1 55 4.59736e-17 PREDICTED: Anas platyrhynchos mitochondrial ribosomal protein S9 (MRPS9), mRNA K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 Q0P5H7 923 9.5e-98 Probable arginine--tRNA ligase, mitochondrial OS=Bos taurus GN=RARS2 PE=2 SV=1 PF00380//PF02572//PF00750//PF05746 Ribosomal protein S9/S16//ATP:corrinoid adenosyltransferase BtuR/CobO/CobP//tRNA synthetases class I (R)//DALR anticodon binding domain GO:0006420//GO:0042254//GO:0009236//GO:0006525//GO:0015994//GO:0006412//GO:0006560 arginyl-tRNA aminoacylation//ribosome biogenesis//cobalamin biosynthetic process//arginine metabolic process//chlorophyll metabolic process//translation//proline metabolic process GO:0003735//GO:0005524//GO:0008817//GO:0004814 structural constituent of ribosome//ATP binding//cob(I)yrinic acid a,c-diamide adenosyltransferase activity//arginine-tRNA ligase activity GO:0005840 ribosome KOG1195 Arginyl-tRNA synthetase Cluster-8309.39020 BP_3 88.94 6.37 965 478252801 ENN73192.1 581 2.7e-57 hypothetical protein YQE_10171, partial [Dendroctonus ponderosae] 462301115 APGK01050708.1 87 1.85039e-35 Dendroctonus ponderosae Seq01050718, whole genome shotgun sequence -- -- -- -- Q969T9 333 6.3e-30 WW domain-binding protein 2 OS=Homo sapiens GN=WBP2 PE=1 SV=1 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0043130//GO:0032266 ubiquitin binding//phosphatidylinositol-3-phosphate binding -- -- KOG3294 WW domain binding protein WBP-2, contains GRAM domain Cluster-8309.39023 BP_3 388.62 4.36 4584 642922300 XP_008193101.1 1696 6.5e-186 PREDICTED: LOW QUALITY PROTEIN: isovaleryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 1323 4.8e-144 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF04179//PF13180//PF00595//PF02770//PF02270//PF02771//PF00441 Initiator tRNA phosphoribosyl transferase//PDZ domain//PDZ domain (Also known as DHR or GLGF)//Acyl-CoA dehydrogenase, middle domain//Transcription initiation factor IIF, beta subunit//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006367//GO:0055114//GO:0006118//GO:0006366//GO:0019988//GO:0008152 transcription initiation from RNA polymerase II promoter//oxidation-reduction process//obsolete electron transport//transcription from RNA polymerase II promoter//charged-tRNA amino acid modification//metabolic process GO:0016627//GO:0050660//GO:0005515//GO:0043399//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//protein binding//tRNA A64-2'-O-ribosylphosphate transferase activity//acyl-CoA dehydrogenase activity GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.39024 BP_3 868.40 19.30 2460 642928317 XP_971226.2 1703 5.4e-187 PREDICTED: protein arginine N-methyltransferase 1 isoform X1 [Tribolium castaneum] 795023681 XM_012005633.1 138 2.14855e-63 PREDICTED: Vollenhovia emeryi protein arginine N-methyltransferase 1 (LOC105558112), transcript variant X2, mRNA K11434 PRMT1 protein arginine N-methyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11434 Q99873 1351 1.4e-147 Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=1 SV=2 PF05175//PF01135//PF08241//PF02390 Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase domain//Putative methyltransferase GO:0006464//GO:0008152//GO:0006400//GO:0008033//GO:0046500//GO:0006479//GO:0009451 cellular protein modification process//metabolic process//tRNA modification//tRNA processing//S-adenosylmethionine metabolic process//protein methylation//RNA modification GO:0008168//GO:0004719//GO:0008176 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.39025 BP_3 1004.35 6.18 8130 91077082 XP_969760.1 2971 0.0e+00 PREDICTED: protein NRDE2 homolog [Tribolium castaneum]>gi|270002034|gb|EEZ98481.1| hypothetical protein TcasGA2_TC000974 [Tribolium castaneum] 742984403 CP010377.1 47 2.76625e-12 Enterobacter cloacae strain 34983, complete genome K03639 MOCS1, moaA cyclic pyranopterin phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K03639 Q8IQF1 1535 2.2e-168 Molybdenum cofactor biosynthesis protein 1 OS=Drosophila melanogaster GN=Mocs1 PE=2 SV=1 PF05373//PF04055//PF00057//PF15015//PF06463//PF01967 L-proline 3-hydroxylase, C-terminal//Radical SAM superfamily//Low-density lipoprotein receptor domain class A//Spermatogenesis-associated, N-terminal//Molybdenum Cofactor Synthesis C//MoaC family GO:0006777//GO:0055114//GO:0007283 Mo-molybdopterin cofactor biosynthetic process//oxidation-reduction process//spermatogenesis GO:0003824//GO:0005515//GO:0016706//GO:0051536//GO:0051539 catalytic activity//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron-sulfur cluster binding//4 iron, 4 sulfur cluster binding GO:0005794//GO:0019008 Golgi apparatus//molybdopterin synthase complex KOG2876 Molybdenum cofactor biosynthesis pathway protein Cluster-8309.39026 BP_3 774.94 15.23 2744 91086797 XP_973406.1 1680 2.8e-184 PREDICTED: CTD small phosphatase-like protein 2 [Tribolium castaneum]>gi|270009707|gb|EFA06155.1| hypothetical protein TcasGA2_TC009000 [Tribolium castaneum] 642929007 XM_008197430.1 42 5.57252e-10 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 8 (LOC662164), mRNA K17616 CTDSPL2 CTD small phosphatase-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17616 Q66KM5 893 2.1e-94 CTD small phosphatase-like protein 2 OS=Xenopus tropicalis GN=ctdspl2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.39027 BP_3 211.48 3.81 2969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39028 BP_3 31.02 0.69 2465 189234454 XP_967960.2 1161 3.8e-124 PREDICTED: aldehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270002022|gb|EEZ98469.1| hypothetical protein TcasGA2_TC000960 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 Q5RF00 923 6.2e-98 Aldehyde dehydrogenase, mitochondrial OS=Pongo abelii GN=ALDH2 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491//GO:0016620 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.39030 BP_3 248.37 2.85 4488 189237458 XP_967667.2 1462 8.6e-159 PREDICTED: solute carrier family 35 member E2-like [Tribolium castaneum] -- -- -- -- -- K15284 SLC35E2 solute carrier family 35, member E2 http://www.genome.jp/dbget-bin/www_bget?ko:K15284 Q8C811 857 5.1e-90 Solute carrier family 35 member E2 OS=Mus musculus GN=Slc35e2 PE=2 SV=1 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.39031 BP_3 698.73 9.22 3944 270013544 EFA09992.1 697 3.9e-70 hypothetical protein TcasGA2_TC012159 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3ZY60 238 2.7e-18 Pleckstrin homology domain-containing family A member 8 OS=Rattus norvegicus GN=Plekha8 PE=1 SV=1 PF08718 Glycolipid transfer protein (GLTP) GO:0046836 glycolipid transport GO:0051861//GO:0017089 glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG3221 Glycolipid transfer protein Cluster-8309.39032 BP_3 2949.00 25.04 5969 478263046 ENN81446.1 3102 0.0e+00 hypothetical protein YQE_02139, partial [Dendroctonus ponderosae] -- -- -- -- -- K14297 NUP98, ADAR2, NUP116 nuclear pore complex protein Nup98-Nup96 http://www.genome.jp/dbget-bin/www_bget?ko:K14297 P52948 679 2.9e-69 Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens GN=NUP98 PE=1 SV=4 PF06455//PF04096 NADH dehydrogenase subunit 5 C-terminus//Nucleoporin autopeptidase GO:0055114//GO:0015992//GO:0006744//GO:0006814//GO:0006810//GO:0006120//GO:0042773 oxidation-reduction process//proton transport//ubiquinone biosynthetic process//sodium ion transport//transport//mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled electron transport GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005643 nuclear pore KOG0845 Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) Cluster-8309.39035 BP_3 299.71 8.19 2056 91094383 XP_971062.1 1109 3.4e-118 PREDICTED: alanyl-tRNA editing protein Aarsd1 [Tribolium castaneum]>gi|270014911|gb|EFA11359.1| hypothetical protein TcasGA2_TC011516 [Tribolium castaneum] 332375886 BT128123.1 64 2.45117e-22 Dendroctonus ponderosae clone DPO1131_O04 unknown mRNA K07050 AARSD1, ALAX misacylated tRNA(Ala) deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K07050 Q7ZYJ9 779 2.6e-81 Alanyl-tRNA editing protein Aarsd1-B OS=Xenopus laevis GN=aarsd1-b PE=2 SV=1 PF01176//PF07973//PF01411//PF01200//PF03367 Translation initiation factor 1A / IF-1//Threonyl and Alanyl tRNA synthetase second additional domain//tRNA synthetases class II (A)//Ribosomal protein S28e//ZPR1 zinc-finger domain GO:0006419//GO:0006412//GO:0006446//GO:0006531//GO:0006413//GO:0006522//GO:0043039//GO:0042254 alanyl-tRNA aminoacylation//translation//regulation of translational initiation//aspartate metabolic process//translational initiation//alanine metabolic process//tRNA aminoacylation//ribosome biogenesis GO:0003723//GO:0004813//GO:0003676//GO:0003743//GO:0005524//GO:0003735//GO:0000166//GO:0008270//GO:0016876 RNA binding//alanine-tRNA ligase activity//nucleic acid binding//translation initiation factor activity//ATP binding//structural constituent of ribosome//nucleotide binding//zinc ion binding//ligase activity, forming aminoacyl-tRNA and related compounds GO:0005622//GO:0005840//GO:0005737 intracellular//ribosome//cytoplasm KOG3502 40S ribosomal protein S28 Cluster-8309.39037 BP_3 288.50 2.05 7085 189241799 XP_970228.2 3101 0.0e+00 PREDICTED: inverted formin-2 [Tribolium castaneum]>gi|270001160|gb|EEZ97607.1| hypothetical protein TcasGA2_TC011477 [Tribolium castaneum] 642925592 XM_008196391.1 437 0 PREDICTED: Tribolium castaneum uncharacterized LOC658801 (LOC658801), mRNA -- -- -- -- Q9C0D6 714 3.1e-73 FH2 domain-containing protein 1 OS=Homo sapiens GN=FHDC1 PE=1 SV=2 PF06371//PF06367 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain GO:0016043//GO:0030036 cellular component organization//actin cytoskeleton organization GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.39039 BP_3 300.98 4.63 3424 478257607 ENN77759.1 744 1.2e-75 hypothetical protein YQE_05731, partial [Dendroctonus ponderosae]>gi|546677511|gb|ERL88337.1| hypothetical protein D910_05724, partial [Dendroctonus ponderosae] -- -- -- -- -- K09880 mtnC, ENOPH1 enolase-phosphatase E1 http://www.genome.jp/dbget-bin/www_bget?ko:K09880 Q17Q32 446 1.8e-42 Enolase-phosphatase E1 OS=Aedes aegypti GN=AAEL000109 PE=3 SV=1 PF12689 Acid Phosphatase -- -- GO:0016791 phosphatase activity -- -- KOG2630 Enolase-phosphatase E-1 Cluster-8309.3904 BP_3 30.67 1.38 1363 91094905 XP_973449.1 1340 3.7e-145 PREDICTED: F-box/SPRY domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270006590|gb|EFA03038.1| hypothetical protein TcasGA2_TC010464 [Tribolium castaneum] 242007554 XM_002424560.1 192 1.12771e-93 Pediculus humanus corporis F-box/SPRY-domain protein, putative, mRNA K10319 FBXO45 F-box protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K10319 B4HQ29 1187 8.3e-129 F-box/SPRY domain-containing protein 1 OS=Drosophila sechellia GN=Fsn PE=3 SV=1 PF00646//PF12937//PF00622 F-box domain//F-box-like//SPRY domain -- -- GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.39040 BP_3 714.66 21.50 1894 478256079 ENN76278.1 755 3.5e-77 hypothetical protein YQE_07242, partial [Dendroctonus ponderosae]>gi|546676009|gb|ERL87104.1| hypothetical protein D910_04504 [Dendroctonus ponderosae] 617638670 XM_007531235.1 76 4.81197e-29 PREDICTED: Erinaceus europaeus oligosaccharyltransferase complex subunit (non-catalytic) (OSTC), mRNA -- -- -- -- Q5M9B7 574 1.4e-57 Oligosaccharyltransferase complex subunit ostc-B OS=Xenopus laevis GN=ostc-b PE=2 SV=1 PF13202//PF12763//PF13833//PF10591//PF13405//PF00036//PF13499 EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF-hand domain pair GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG3356 Predicted membrane protein Cluster-8309.39042 BP_3 1100.46 15.31 3756 91082907 XP_972373.1 1236 1.2e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.8e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF12740//PF10503//PF00326//PF00787//PF07224 Chlorophyllase enzyme//Esterase PHB depolymerase//Prolyl oligopeptidase family//PX domain//Chlorophyllase GO:0015996//GO:0015947//GO:0046294//GO:0015994//GO:0006508 chlorophyll catabolic process//methane metabolic process//formaldehyde catabolic process//chlorophyll metabolic process//proteolysis GO:0047746//GO:0035091//GO:0008236//GO:0018738 chlorophyllase activity//phosphatidylinositol binding//serine-type peptidase activity//S-formylglutathione hydrolase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.39043 BP_3 127.84 0.53 11893 642918413 XP_008191462.1 2522 2.8e-281 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|642918415|ref|XP_008191463.1| PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|270003254|gb|EEZ99701.1| hypothetical protein TcasGA2_TC002462 [Tribolium castaneum] 642931619 XM_966443.2 176 7.88888e-84 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 P50416 1614 2.2e-177 Carnitine O-palmitoyltransferase 1, liver isoform OS=Homo sapiens GN=CPT1A PE=1 SV=2 PF01532//PF00755 Glycosyl hydrolase family 47//Choline/Carnitine o-acyltransferase GO:0005975 carbohydrate metabolic process GO:0004571//GO:0016746//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups//calcium ion binding GO:0016020 membrane KOG2430 Glycosyl hydrolase, family 47 Cluster-8309.39044 BP_3 19.62 0.38 2783 642939131 XP_967038.2 1299 4.3e-140 PREDICTED: stress-induced-phosphoprotein 1-like [Tribolium castaneum]>gi|270016347|gb|EFA12793.1| hypothetical protein TcasGA2_TC002163 [Tribolium castaneum] 831315386 XM_012834849.1 54 1.20642e-16 PREDICTED: Clupea harengus stress-induced phosphoprotein 1 (stip1), mRNA K09553 STIP1 stress-induced-phosphoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09553 Q4R8N7 918 2.7e-97 Stress-induced-phosphoprotein 1 OS=Macaca fascicularis GN=STIP1 PE=2 SV=1 PF13181//PF13174//PF00515//PF13374//PF09392//PF13371//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0009405//GO:0015031 pathogenesis//protein transport GO:0005515 protein binding -- -- KOG0548 Molecular co-chaperone STI1 Cluster-8309.39045 BP_3 2878.34 63.95 2461 817086172 XP_012265802.1 1842 4.1e-203 PREDICTED: stress-induced-phosphoprotein 1 isoform X2 [Athalia rosae] 831315386 XM_012834849.1 54 1.06578e-16 PREDICTED: Clupea harengus stress-induced phosphoprotein 1 (stip1), mRNA K09553 STIP1 stress-induced-phosphoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09553 Q4R8N7 1433 4.5e-157 Stress-induced-phosphoprotein 1 OS=Macaca fascicularis GN=STIP1 PE=2 SV=1 PF13181//PF02064//PF13174//PF13374//PF00515//PF13371//PF09392//PF13176//PF13414 Tetratricopeptide repeat//MAS20 protein import receptor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Tetratricopeptide repeat//TPR repeat GO:0006605//GO:0009405//GO:0006886//GO:0015031 protein targeting//pathogenesis//intracellular protein transport//protein transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG0548 Molecular co-chaperone STI1 Cluster-8309.39046 BP_3 323.35 2.39 6823 91082533 XP_973629.1 1823 1.8e-200 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X1 [Tribolium castaneum]>gi|270007557|gb|EFA04005.1| hypothetical protein TcasGA2_TC014154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 872 1.4e-91 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.39047 BP_3 1852.53 72.05 1531 91084671 XP_966504.1 1223 1.5e-131 PREDICTED: lambda-crystallin [Tribolium castaneum]>gi|270008625|gb|EFA05073.1| hypothetical protein TcasGA2_TC015170 [Tribolium castaneum] -- -- -- -- -- K13247 CRYL1 L-gulonate 3-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K13247 Q811X6 788 1.7e-82 Lambda-crystallin homolog OS=Rattus norvegicus GN=Cryl1 PE=2 SV=3 PF12592//PF01210//PF00056//PF00070//PF03446//PF03721//PF02826//PF02737//PF07992//PF00725 Protein of unknown function (DUF3763)//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//NAD binding domain of 6-phosphogluconate dehydrogenase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GO:0006552//GO:0006631//GO:0046168//GO:0018874//GO:0006098//GO:0006633//GO:0006554//GO:0055114//GO:0019521//GO:0006568//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//glycerol-3-phosphate catabolic process//benzoate metabolic process//pentose-phosphate shunt//fatty acid biosynthetic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process//valine catabolic process//isoleucine catabolic process GO:0016820//GO:0016491//GO:0051287//GO:0070403//GO:0004616//GO:0003857//GO:0016616 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//oxidoreductase activity//NAD binding//NAD+ binding//phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2305 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.39048 BP_3 186.08 3.05 3236 332375116 AEE62699.1 2415 1.9e-269 unknown [Dendroctonus ponderosae]>gi|546676201|gb|ERL87268.1| hypothetical protein D910_04664 [Dendroctonus ponderosae] -- -- -- -- -- K12825 SF3A1, SAP114 splicing factor 3A subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12825 Q8K4Z5 1372 7.0e-150 Splicing factor 3A subunit 1 OS=Mus musculus GN=Sf3a1 PE=1 SV=1 PF14560//PF00240//PF01805 Ubiquitin-like domain//Ubiquitin family//Surp module GO:0006396 RNA processing GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.39049 BP_3 258.42 7.99 1850 189238186 XP_966734.2 2332 4.7e-260 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 768442048 XM_011564477.1 347 1.05645e-179 PREDICTED: Plutella xylostella coronin-6 (LOC105392798), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 2.3e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.39050 BP_3 1158.17 4.81 11895 270015748 EFA12196.1 1838 5.8e-202 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFU5 248 5.6e-19 Inositol polyphosphate multikinase OS=Homo sapiens GN=IPMK PE=1 SV=1 PF01218//PF08702//PF01105//PF00642//PF10473//PF13912//PF03938//PF05529//PF16716//PF00096//PF00867//PF03770//PF04111//PF00695 Coproporphyrinogen III oxidase//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//C2H2-type zinc finger//Outer membrane protein (OmpH-like)//B-cell receptor-associated protein 31-like//Bone marrow stromal antigen 2//Zinc finger, C2H2 type//XPG I-region//Inositol polyphosphate kinase//Autophagy protein Apg6//Major surface antigen from hepadnavirus GO:0006779//GO:0055114//GO:0006886//GO:0006810//GO:0051258//GO:0006914//GO:0007165//GO:0030168//GO:0051607//GO:0015994//GO:0016032 porphyrin-containing compound biosynthetic process//oxidation-reduction process//intracellular protein transport//transport//protein polymerization//autophagy//signal transduction//platelet activation//defense response to virus//chlorophyll metabolic process//viral process GO:0005102//GO:0051082//GO:0008440//GO:0008134//GO:0045502//GO:0046872//GO:0004518//GO:0030674//GO:0042803//GO:0004109 receptor binding//unfolded protein binding//inositol-1,4,5-trisphosphate 3-kinase activity//transcription factor binding//dynein binding//metal ion binding//nuclease activity//protein binding, bridging//protein homodimerization activity//coproporphyrinogen oxidase activity GO:0005577//GO:0016021//GO:0005667//GO:0005783//GO:0030286 fibrinogen complex//integral component of membrane//transcription factor complex//endoplasmic reticulum//dynein complex -- -- Cluster-8309.39051 BP_3 146.38 0.84 8703 642937185 XP_008198729.1 2693 3.0e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 4.68392e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.9e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF11744//PF13606//PF02068//PF05033//PF00856//PF05192//PF00023//PF00995 Aluminium activated malate transporter//Ankyrin repeat//Plant PEC family metallothionein//Pre-SET motif//SET domain//MutS domain III//Ankyrin repeat//Sec1 family GO:0006298//GO:0006904//GO:0015743//GO:0034968//GO:0016192//GO:0006479//GO:0006554 mismatch repair//vesicle docking involved in exocytosis//malate transport//histone lysine methylation//vesicle-mediated transport//protein methylation//lysine catabolic process GO:0005524//GO:0018024//GO:0005515//GO:0008270//GO:0030983 ATP binding//histone-lysine N-methyltransferase activity//protein binding//zinc ion binding//mismatched DNA binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.39053 BP_3 1643.84 44.66 2066 642934646 XP_972350.2 538 5.5e-52 PREDICTED: uncharacterized protein LOC661069 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CJ61 206 7.2e-15 CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Mus musculus GN=Cmtm4 PE=2 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane KOG4788 Members of chemokine-like factor super family and related proteins Cluster-8309.39054 BP_3 364.90 13.39 1605 642939230 XP_008194770.1 1351 2.3e-146 PREDICTED: uncharacterized protein LOC656988 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39055 BP_3 531.59 4.66 5787 642936966 XP_008198632.1 3242 0.0e+00 PREDICTED: rab GTPase-activating protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RAN1 1662 2.9e-183 Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1 PF07776//PF08127//PF14719//PF00096//PF00170//PF16622//PF07660//PF13912//PF02892//PF00640//PF05443//PF13465//PF08649 Zinc-finger associated domain (zf-AD)//Peptidase family C1 propeptide//Phosphotyrosine interaction domain (PTB/PID)//Zinc finger, C2H2 type//bZIP transcription factor//zinc-finger C2H2-type//Secretin and TonB N terminus short domain//C2H2-type zinc finger//BED zinc finger//Phosphotyrosine interaction domain (PTB/PID)//ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//DASH complex subunit Dad1 GO:0006508//GO:0050790//GO:0030472//GO:0006355 proteolysis//regulation of catalytic activity//mitotic spindle organization in nucleus//regulation of transcription, DNA-templated GO:0046872//GO:0004197//GO:0003677//GO:0005515//GO:0043565//GO:0008270//GO:0003700 metal ion binding//cysteine-type endopeptidase activity//DNA binding//protein binding//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0072686//GO:0019867//GO:0005634//GO:0005667//GO:0042729 mitotic spindle//outer membrane//nucleus//transcription factor complex//DASH complex -- -- Cluster-8309.39056 BP_3 2433.63 27.93 4491 270003174 EEZ99621.1 2428 8.4e-271 hypothetical protein TcasGA2_TC002139 [Tribolium castaneum] 817079739 XM_012406879.1 41 3.29722e-09 PREDICTED: Athalia rosae thioredoxin-related transmembrane protein 1-like (LOC105689684), mRNA K14832 MAK21, NOC1, CEBPZ ribosome biogenesis protein MAK21 http://www.genome.jp/dbget-bin/www_bget?ko:K14832 Q03701 1316 3.0e-143 CCAAT/enhancer-binding protein zeta OS=Homo sapiens GN=CEBPZ PE=1 SV=3 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein Cluster-8309.39061 BP_3 2012.68 23.92 4348 665814511 XP_008555868.1 4780 0.0e+00 PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor]>gi|665814513|ref|XP_008555869.1| PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor] 749751938 XM_011139992.1 608 0 PREDICTED: Harpegnathos saltator regulator of nonsense transcripts 1 (LOC105182511), transcript variant X4, mRNA K14326 UPF1, RENT1 regulator of nonsense transcripts 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14326 Q9EPU0 3940 0.0e+00 Regulator of nonsense transcripts 1 OS=Mus musculus GN=Upf1 PE=1 SV=2 PF00580//PF04851//PF00270//PF07728//PF00004//PF00437//PF09416//PF00448 UvrD/REP helicase N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//RNA helicase (UPF2 interacting domain)//SRP54-type protein, GTPase domain GO:0006810//GO:0000184//GO:0006614 transport//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//SRP-dependent cotranslational protein targeting to membrane GO:0008270//GO:0005525//GO:0003676//GO:0016887//GO:0005524//GO:0004386//GO:0016787//GO:0003677 zinc ion binding//GTP binding//nucleic acid binding//ATPase activity//ATP binding//helicase activity//hydrolase activity//DNA binding GO:0005737 cytoplasm KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.39065 BP_3 4340.74 50.12 4466 642939347 XP_970218.2 2431 3.7e-271 PREDICTED: lipase maturation factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKZ9 1010 9.1e-108 Lipase maturation factor 2 OS=Gallus gallus GN=LMF2 PE=2 SV=2 PF01741 Large-conductance mechanosensitive channel, MscL GO:0006811//GO:0006810 ion transport//transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.39066 BP_3 120.68 5.91 1276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39069 BP_3 351.58 3.95 4580 642912316 XP_969236.2 1282 6.6e-138 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IF69 737 4.2e-76 NHL repeat-containing protein 2 OS=Bos taurus GN=NHLRC2 PE=2 SV=1 PF01731//PF00085//PF01436//PF00578 Arylesterase//Thioredoxin//NHL repeat//AhpC/TSA family GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0005515//GO:0004064//GO:0016209 oxidoreductase activity//protein binding//arylesterase activity//antioxidant activity -- -- -- -- Cluster-8309.39071 BP_3 305.03 3.07 5076 478263483 ENN81838.1 154 4.6e-07 hypothetical protein YQE_01777, partial [Dendroctonus ponderosae]>gi|546685487|gb|ERL94985.1| hypothetical protein D910_12257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39072 BP_3 657.06 9.80 3522 642932977 XP_008197213.1 525 3.0e-50 PREDICTED: BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2 [Tribolium castaneum] 524881414 XM_005097302.1 92 1.15049e-37 PREDICTED: Aplysia californica BUB3-interacting and GLEBS motif-containing protein ZNF207-like (LOC101854635), mRNA -- -- -- -- Q7ZXV8 416 5.4e-39 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Xenopus laevis GN=znf207 PE=1 SV=1 PF00096//PF06467//PF02892 Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//BED zinc finger -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding -- -- KOG2893 Zn finger protein Cluster-8309.39073 BP_3 1518.11 18.28 4294 282165741 NP_001164113.1 2648 2.5e-296 cap-n-collar [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 6.1e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF07716//PF00170//PF03131//PF03126 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor//Plus-3 domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3863 bZIP transcription factor NRF1 Cluster-8309.39074 BP_3 2766.30 13.10 10467 642913929 XP_008201218.1 1980 1.7e-218 PREDICTED: headcase protein [Tribolium castaneum] 642913928 XM_008202996.1 693 0 PREDICTED: Tribolium castaneum headcase protein (LOC664275), mRNA -- -- -- -- Q9N2M8 849 1.0e-88 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 PF10403//PF02701 Rad4 beta-hairpin domain 1//Dof domain, zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3816 Cell differentiation regulator of the Headcase family Cluster-8309.39075 BP_3 5.79 0.78 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39076 BP_3 654.40 11.44 3049 642922790 XP_008193326.1 1286 1.5e-138 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 688 1.4e-70 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39078 BP_3 495.12 14.49 1939 189235966 XP_969617.2 810 1.5e-83 PREDICTED: zinc finger CCCH domain-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IXZ2 320 4.1e-28 Zinc finger CCCH domain-containing protein 3 OS=Homo sapiens GN=ZC3H3 PE=1 SV=3 PF00642//PF00711 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Beta defensin GO:0006952 defense response GO:0046872 metal ion binding GO:0005576 extracellular region KOG1492 C3H1-type Zn-finger protein Cluster-8309.39079 BP_3 99.58 2.40 2295 728416984 AIY68330.1 1410 4.7e-153 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01050 BCHE cholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01050 P35502 650 2.6e-66 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.3908 BP_3 60.27 7.19 696 189236939 XP_970278.2 276 4.5e-22 PREDICTED: histidine-rich glycoprotein [Tribolium castaneum]>gi|270008064|gb|EFA04512.1| hypothetical protein TcasGA2_TC016307 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 203 5.4e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.39080 BP_3 794.09 14.09 3008 328777746 XP_396692.3 823 7.2e-85 PREDICTED: roughened isoform X3 [Apis mellifera]>gi|340717290|ref|XP_003397118.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|350407287|ref|XP_003488045.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|380017382|ref|XP_003692636.1| PREDICTED: ras-like protein 3 [Apis florea]>gi|571537886|ref|XP_006558879.1| PREDICTED: roughened isoform X1 [Apis mellifera]>gi|571537889|ref|XP_006558880.1| PREDICTED: roughened isoform X2 [Apis mellifera]>gi|572258774|ref|XP_006607754.1| PREDICTED: ras-like protein 3-like isoform X1 [Apis dorsata]>gi|572258776|ref|XP_006607755.1| PREDICTED: ras-like protein 3-like isoform X2 [Apis dorsata]>gi|572258778|ref|XP_006607756.1| PREDICTED: ras-like protein 3-like isoform X3 [Apis dorsata]>gi|572258780|ref|XP_006607757.1| PREDICTED: ras-like protein 3-like isoform X4 [Apis dorsata]>gi|808126889|ref|XP_012166429.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126891|ref|XP_012166430.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126893|ref|XP_012166431.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|815906255|ref|XP_012238943.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906257|ref|XP_012238944.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906259|ref|XP_012238945.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|169668013|gb|ACA64426.1| RAS-like protein [Bombus ignitus] 642938605 XM_008201640.1 384 0 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 803 6.2e-84 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF00071//PF00025//PF00268//PF01926//PF03193//PF08477 Ras family//ADP-ribosylation factor family//Ribonucleotide reductase, small chain//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0055114//GO:0006184//GO:0009186 small GTPase mediated signal transduction//oxidation-reduction process//obsolete GTP catabolic process//deoxyribonucleoside diphosphate metabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.39082 BP_3 1398.17 19.11 3818 91084051 XP_967428.1 4920 0.0e+00 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] 642924822 XM_962335.2 787 0 PREDICTED: Tribolium castaneum importin-5 (LOC655773), mRNA -- -- -- -- Q8BKC5 2943 0.0e+00 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF09044//PF01602//PF00514//PF03810//PF02985 Kp4//Adaptin N terminal region//Armadillo/beta-catenin-like repeat//Importin-beta N-terminal domain//HEAT repeat GO:0016192//GO:0006886//GO:0009405 vesicle-mediated transport//intracellular protein transport//pathogenesis GO:0005515//GO:0008536 protein binding//Ran GTPase binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.39083 BP_3 3490.50 62.98 2963 91088789 XP_968000.1 1311 1.8e-141 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02833 361 1.1e-32 Insulin-like growth factor-binding protein complex acid labile subunit OS=Papio hamadryas GN=IGFALS PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.39084 BP_3 695.82 9.25 3919 91084051 XP_967428.1 4713 0.0e+00 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] 642924822 XM_962335.2 756 0 PREDICTED: Tribolium castaneum importin-5 (LOC655773), mRNA -- -- -- -- Q8BKC5 2888 0.0e+00 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF00514//PF01602//PF09044//PF03810//PF02985 Armadillo/beta-catenin-like repeat//Adaptin N terminal region//Kp4//Importin-beta N-terminal domain//HEAT repeat GO:0016192//GO:0006886//GO:0009405 vesicle-mediated transport//intracellular protein transport//pathogenesis GO:0005515//GO:0008536 protein binding//Ran GTPase binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.39085 BP_3 105.85 3.23 1871 291170322 ADD82417.1 230 2.6e-16 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39086 BP_3 34.76 0.37 4834 189240719 XP_974316.2 3717 0.0e+00 PREDICTED: TBC1 domain family member 9, partial [Tribolium castaneum] 640785773 XM_008050426.1 160 2.50395e-75 PREDICTED: Tarsius syrichta TBC1 domain family, member 9B (with GRAM domain) (TBC1D9B), transcript variant X2, mRNA -- -- -- -- Q6ZT07 2351 3.1e-263 TBC1 domain family member 9 OS=Homo sapiens GN=TBC1D9 PE=2 SV=2 PF04840//PF13202//PF10637//PF13833//PF00036//PF13405//PF13499 Vps16, C-terminal region//EF hand//Oxoglutarate and iron-dependent oxygenase degradation C-term//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair GO:0006886//GO:0055114 intracellular protein transport//oxidation-reduction process GO:0005506//GO:0005509//GO:0016706//GO:0031418 iron ion binding//calcium ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//L-ascorbic acid binding GO:0005737 cytoplasm KOG4347 GTPase-activating protein VRP Cluster-8309.39088 BP_3 152.35 0.56 13392 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 221 8.57747e-109 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q96EP0 878 5.5e-92 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens GN=RNF31 PE=1 SV=1 PF07975//PF13465//PF01426//PF05121//PF08273//PF02845//PF13912//PF09182//PF00412//PF00641//PF05495//PF00096//PF07776//PF13806 TFIIH C1-like domain//Zinc-finger double domain//BAH domain//Gas vesicle protein K//Zinc-binding domain of primase-helicase//CUE domain//C2H2-type zinc finger//Bacterial purine repressor, N-terminal//LIM domain//Zn-finger in Ran binding protein and others//CHY zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Rieske-like [2Fe-2S] domain GO:0006269//GO:0006355//GO:0055114//GO:0006281//GO:0031412//GO:0006807//GO:0006351//GO:0042128 DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//oxidation-reduction process//DNA repair//gas vesicle organization//nitrogen compound metabolic process//transcription, DNA-templated//nitrate assimilation GO:0008942//GO:0008270//GO:0003682//GO:0003896//GO:0046872//GO:0003677//GO:0004386//GO:0005515 nitrite reductase [NAD(P)H] activity//zinc ion binding//chromatin binding//DNA primase activity//metal ion binding//DNA binding//helicase activity//protein binding GO:0005730//GO:0000785//GO:0005657//GO:0005634 nucleolus//chromatin//replication fork//nucleus -- -- Cluster-8309.39089 BP_3 1065.00 28.42 2098 91078804 XP_970300.1 2079 1.2e-230 PREDICTED: glycosyltransferase 25 family member [Tribolium castaneum]>gi|270003725|gb|EFA00173.1| hypothetical protein TcasGA2_TC002995 [Tribolium castaneum] -- -- -- -- -- K11703 GLT25D collagen beta-1,O-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11703 Q17FB8 1510 4.5e-166 Glycosyltransferase 25 family member OS=Aedes aegypti GN=AAEL003481 PE=3 SV=1 -- -- GO:0009103 lipopolysaccharide biosynthetic process -- -- -- -- KOG4179 Lysyl hydrolase/glycosyltransferase family 25 Cluster-8309.39090 BP_3 30.95 0.36 4385 270001798 EEZ98245.1 3524 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 468 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q10057 146 1.4e-07 Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC1F5.02 PE=3 SV=1 PF02382//PF00085//PF01791//PF02020 RTX N-terminal domain//Thioredoxin//DeoC/LacD family aldolase//eIF4-gamma/eIF5/eIF2-epsilon GO:0045454//GO:0009405 cell redox homeostasis//pathogenesis GO:0016829//GO:0005515//GO:0005509 lyase activity//protein binding//calcium ion binding GO:0005576 extracellular region KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.39091 BP_3 4115.00 1359.90 437 264667391 ACY71281.1 534 3.4e-52 ribosomal protein S6 [Chrysomela tremula] 462382418 APGK01021662.1 96 7.97552e-41 Dendroctonus ponderosae Seq01021672, whole genome shotgun sequence K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 Q94624 511 6.5e-51 40S ribosomal protein S6 OS=Manduca sexta GN=RpS6 PE=2 SV=1 PF01092 Ribosomal protein S6e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1646 40S ribosomal protein S6 Cluster-8309.39092 BP_3 79.20 1.16 3586 91082905 XP_972330.1 2058 5.4e-228 PREDICTED: eukaryotic translation initiation factor 2A [Tribolium castaneum]>gi|270007067|gb|EFA03515.1| hypothetical protein TcasGA2_TC013517 [Tribolium castaneum] -- -- -- -- -- K15026 EIF2A translation initiation factor 2A http://www.genome.jp/dbget-bin/www_bget?ko:K15026 Q7ZY11 1191 7.5e-129 Eukaryotic translation initiation factor 2A OS=Xenopus laevis GN=eif2a PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG2315 Predicted translation initiation factor related to eIF-3a Cluster-8309.39093 BP_3 181.49 9.90 1175 795378639 XP_011937115.1 412 1.3e-37 PREDICTED: 40S ribosomal protein S9 isoform X1 [Cercocebus atys]>gi|795378643|ref|XP_011937116.1| PREDICTED: 40S ribosomal protein S9 isoform X1 [Cercocebus atys] 642933492 XM_962542.2 120 1.02443e-53 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 P55935 327 3.8e-29 40S ribosomal protein S9 OS=Drosophila melanogaster GN=RpS9 PE=1 SV=2 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain -- -- GO:0019843//GO:0003723 rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.39095 BP_3 177.00 10.53 1102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39096 BP_3 915.36 8.55 5453 642924931 XP_008194102.1 343 6.0e-29 PREDICTED: uncharacterized protein LOC103313203 [Tribolium castaneum]>gi|642924933|ref|XP_008194103.1| PREDICTED: uncharacterized protein LOC103313203 [Tribolium castaneum]>gi|642924935|ref|XP_008194105.1| PREDICTED: uncharacterized protein LOC103313203 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15001 AP-5 complex subunit sigma-1 GO:0000724//GO:0016197 double-strand break repair via homologous recombination//endosomal transport -- -- GO:0030119 AP-type membrane coat adaptor complex -- -- Cluster-8309.39097 BP_3 1724.92 28.03 3258 328777746 XP_396692.3 823 7.8e-85 PREDICTED: roughened isoform X3 [Apis mellifera]>gi|340717290|ref|XP_003397118.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|350407287|ref|XP_003488045.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|380017382|ref|XP_003692636.1| PREDICTED: ras-like protein 3 [Apis florea]>gi|571537886|ref|XP_006558879.1| PREDICTED: roughened isoform X1 [Apis mellifera]>gi|571537889|ref|XP_006558880.1| PREDICTED: roughened isoform X2 [Apis mellifera]>gi|572258774|ref|XP_006607754.1| PREDICTED: ras-like protein 3-like isoform X1 [Apis dorsata]>gi|572258776|ref|XP_006607755.1| PREDICTED: ras-like protein 3-like isoform X2 [Apis dorsata]>gi|572258778|ref|XP_006607756.1| PREDICTED: ras-like protein 3-like isoform X3 [Apis dorsata]>gi|572258780|ref|XP_006607757.1| PREDICTED: ras-like protein 3-like isoform X4 [Apis dorsata]>gi|808126889|ref|XP_012166429.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126891|ref|XP_012166430.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126893|ref|XP_012166431.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|815906255|ref|XP_012238943.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906257|ref|XP_012238944.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906259|ref|XP_012238945.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|169668013|gb|ACA64426.1| RAS-like protein [Bombus ignitus] 642938605 XM_008201640.1 384 0 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 803 6.7e-84 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF00025//PF00071//PF00268//PF01926//PF08477//PF03193 ADP-ribosylation factor family//Ras family//Ribonucleotide reductase, small chain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0055114//GO:0007264//GO:0009186//GO:0006184 oxidation-reduction process//small GTPase mediated signal transduction//deoxyribonucleoside diphosphate metabolic process//obsolete GTP catabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.39098 BP_3 7324.12 37.05 9821 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 553 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF13639//PF04566//PF10588//PF04513//PF00651//PF01436//PF08165//PF00097//PF03884//PF01601//PF14634//PF00643 Ring finger domain//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Baculovirus polyhedron envelope protein, PEP, C terminus//BTB/POZ domain//NHL repeat//FerA (NUC095) domain//Zinc finger, C3HC4 type (RING finger)//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//zinc-RING finger domain//B-box zinc finger GO:0006144//GO:0006351//GO:0046813//GO:0061025//GO:0006206//GO:0055114 purine nucleobase metabolic process//transcription, DNA-templated//receptor-mediated virion attachment to host cell//membrane fusion//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0016491//GO:0005515//GO:0003677//GO:0046872//GO:0005198//GO:0003899//GO:0008270 oxidoreductase activity//protein binding//DNA binding//metal ion binding//structural molecule activity//DNA-directed RNA polymerase activity//zinc ion binding GO:0019031//GO:0016021//GO:0019028//GO:0005730//GO:0005622 viral envelope//integral component of membrane//viral capsid//nucleolus//intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.39101 BP_3 1781.26 6.67 13171 642931031 XP_008196185.1 5942 0.0e+00 PREDICTED: Ig-like and fibronectin type-III domain-containing protein T04A11.3 [Tribolium castaneum] -- -- -- -- -- K00109 E1.1.99.2 2-hydroxyglutarate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00109 Q964T2 917 1.6e-96 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF01313//PF04142//PF01108//PF04893//PF16656//PF00041//PF13895//PF01266//PF00067//PF00892 Bacterial export proteins, family 3//Nucleotide-sugar transporter//Tissue factor//Yip1 domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//FAD dependent oxidoreductase//Cytochrome P450//EamA-like transporter family GO:0019497//GO:0009306//GO:0055114//GO:0008643//GO:0006771 hexachlorocyclohexane metabolic process//protein secretion//oxidation-reduction process//carbohydrate transport//riboflavin metabolic process GO:0005351//GO:0005506//GO:0003993//GO:0005515//GO:0016491//GO:0016705//GO:0046872//GO:0020037 sugar:proton symporter activity//iron ion binding//acid phosphatase activity//protein binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//metal ion binding//heme binding GO:0016021//GO:0016020//GO:0000139 integral component of membrane//membrane//Golgi membrane -- -- Cluster-8309.39102 BP_3 996.21 14.39 3628 91088643 XP_974406.1 953 7.3e-100 PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|642931990|ref|XP_008196810.1| PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|642931992|ref|XP_008196811.1| PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|270011686|gb|EFA08134.1| hypothetical protein TcasGA2_TC005738 [Tribolium castaneum] -- -- -- -- -- K12163 ANUBL1 AN1-type zinc finger and ubiquitin domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12163 D3Z3C6 316 2.2e-27 AN1-type zinc finger protein 4 OS=Mus musculus GN=Zfand4 PE=3 SV=2 PF00558//PF01764//PF00240//PF14560//PF01428 Vpu protein//Lipase (class 3)//Ubiquitin family//Ubiquitin-like domain//AN1-like Zinc finger GO:0019076//GO:0006629//GO:0006812//GO:0032801 viral release from host cell//lipid metabolic process//cation transport//receptor catabolic process GO:0005515//GO:0005261//GO:0008270 protein binding//cation channel activity//zinc ion binding GO:0033644 host cell membrane KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.39103 BP_3 58.44 3.53 1089 741829289 AJA91071.1 616 2.6e-61 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 365 1.4e-33 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00203//PF00067 Ribosomal protein S19//Cytochrome P450 GO:0055114//GO:0042254//GO:0006412 oxidation-reduction process//ribosome biogenesis//translation GO:0003735//GO:0005506//GO:0020037//GO:0016705 structural constituent of ribosome//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005840 ribosome -- -- Cluster-8309.39104 BP_3 187.86 0.82 11316 642916043 XP_008190869.1 3028 0.0e+00 PREDICTED: ras-GEF domain-containing family member 1B-like isoform X1 [Tribolium castaneum] 808119259 XM_012307759.1 168 2.10147e-79 PREDICTED: Bombus terrestris ras-GEF domain-containing family member 1B-like (LOC100645439), transcript variant X2, mRNA -- -- -- -- Q6DHR3 1300 5.5e-141 Ras-GEF domain-containing family member 1B-A OS=Danio rerio GN=rasgef1ba PE=2 SV=2 PF00412//PF00617//PF13639//PF02209 LIM domain//RasGEF domain//Ring finger domain//Villin headpiece domain GO:0043087//GO:0007010//GO:0007264 regulation of GTPase activity//cytoskeleton organization//small GTPase mediated signal transduction GO:0005085//GO:0008270//GO:0005515//GO:0003779 guanyl-nucleotide exchange factor activity//zinc ion binding//protein binding//actin binding -- -- KOG3541 Predicted guanine nucleotide exchange factor Cluster-8309.39105 BP_3 688.19 5.08 6816 642916047 XP_008190871.1 2817 0.0e+00 PREDICTED: ras-GEF domain-containing family member 1B-like isoform X3 [Tribolium castaneum] 808119259 XM_012307759.1 168 1.26304e-79 PREDICTED: Bombus terrestris ras-GEF domain-containing family member 1B-like (LOC100645439), transcript variant X2, mRNA -- -- -- -- Q6DHR3 1318 2.7e-143 Ras-GEF domain-containing family member 1B-A OS=Danio rerio GN=rasgef1ba PE=2 SV=2 PF13639//PF00412//PF00617 Ring finger domain//LIM domain//RasGEF domain GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0008270//GO:0005085//GO:0005515 zinc ion binding//guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3541 Predicted guanine nucleotide exchange factor Cluster-8309.39106 BP_3 62.00 0.43 7194 270012437 EFA08885.1 537 2.5e-51 hypothetical protein TcasGA2_TC006586 [Tribolium castaneum] 462297259 APGK01052086.1 102 6.51901e-43 Dendroctonus ponderosae Seq01052096, whole genome shotgun sequence -- -- -- -- Q9U6A1 504 6.9e-49 Homeobox protein prospero OS=Drosophila virilis GN=pros PE=3 SV=1 PF15556//PF13855//PF00560//PF05044//PF01874 ZW10 interactor//Leucine rich repeat//Leucine Rich Repeat//Homeo-prospero domain//ATP:dephospho-CoA triphosphoribosyl transferase GO:0007093//GO:0016310 mitotic cell cycle checkpoint//phosphorylation GO:0003677//GO:0005524//GO:0046917//GO:0005515 DNA binding//ATP binding//triphosphoribosyl-dephospho-CoA synthase activity//protein binding GO:0000776 kinetochore KOG3779 Homeobox transcription factor prospero Cluster-8309.39107 BP_3 81.68 1.97 2290 642915291 XP_008190557.1 1094 2.1e-116 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 762 2.7e-79 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF01602//PF00311//PF07571//PF02985//PF10410 Adaptin N terminal region//Phosphoenolpyruvate carboxylase//TAF6 C-terminal HEAT repeat domain//HEAT repeat//DnaB-helicase binding domain of primase GO:0015977//GO:0051090//GO:0006886//GO:0016192//GO:0019643//GO:0006094//GO:0006099 carbon fixation//regulation of sequence-specific DNA binding transcription factor activity//intracellular protein transport//vesicle-mediated transport//reductive tricarboxylic acid cycle//gluconeogenesis//tricarboxylic acid cycle GO:0008964//GO:0005515//GO:0016779 phosphoenolpyruvate carboxylase activity//protein binding//nucleotidyltransferase activity GO:0005634//GO:0030117 nucleus//membrane coat -- -- Cluster-8309.39109 BP_3 274.00 9.30 1712 270013380 EFA09828.1 813 5.9e-84 hypothetical protein TcasGA2_TC011975 [Tribolium castaneum] 815898402 XM_003485921.2 105 3.28523e-45 PREDICTED: Bombus impatiens ubiquitin-conjugating enzyme E2 S (LOC100749747), mRNA K10583 UBE2S, E2EPF ubiquitin-conjugating enzyme E2 S http://www.genome.jp/dbget-bin/www_bget?ko:K10583 B4N208 711 1.6e-73 Ubiquitin-conjugating enzyme E2 S OS=Drosophila willistoni GN=GK16201 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0423 Ubiquitin-protein ligase Cluster-8309.39112 BP_3 102.71 1.95 2824 332376452 AEE63366.1 839 9.5e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08360 CYB561 cytochrome b-561 http://www.genome.jp/dbget-bin/www_bget?ko:K08360 P34465 448 8.5e-43 Putative cytochrome b561 OS=Caenorhabditis elegans GN=F55H2.5 PE=3 SV=1 PF01292//PF03188//PF03124 Prokaryotic cytochrome b561//Eukaryotic cytochrome b561//EXS family GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane KOG1619 Cytochrome b Cluster-8309.39113 BP_3 437.08 5.51 4114 91084051 XP_967428.1 2768 2.9e-310 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] 642924822 XM_962335.2 376 0 PREDICTED: Tribolium castaneum importin-5 (LOC655773), mRNA -- -- -- -- Q8BKC5 1716 1.1e-189 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF03810//PF02985//PF01602//PF09044 Importin-beta N-terminal domain//HEAT repeat//Adaptin N terminal region//Kp4 GO:0016192//GO:0006886//GO:0009405 vesicle-mediated transport//intracellular protein transport//pathogenesis GO:0008536//GO:0005515 Ran GTPase binding//protein binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.39114 BP_3 941.00 14.24 3477 546672689 ERL84480.1 2032 5.4e-225 hypothetical protein D910_01911 [Dendroctonus ponderosae] 807020276 XM_004520531.2 44 5.47387e-11 PREDICTED: Ceratitis capitata putative ATPase N2B (LOC101449143), mRNA K14855 RSA4, NLE1 ribosome assembly protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14855 Q58D20 1615 5.0e-178 Notchless protein homolog 1 OS=Bos taurus GN=NLE1 PE=2 SV=3 PF03969//PF00004//PF00400 AFG1-like ATPase//ATPase family associated with various cellular activities (AAA)//WD domain, G-beta repeat -- -- GO:0005515//GO:0005524 protein binding//ATP binding -- -- KOG0271 Notchless-like WD40 repeat-containing protein Cluster-8309.39118 BP_3 1894.61 10.39 9084 642922965 XP_008200471.1 11133 0.0e+00 PREDICTED: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1 [Tribolium castaneum] 642922964 XM_008202249.1 1875 0 PREDICTED: Tribolium castaneum probable ubiquitin carboxyl-terminal hydrolase FAF-X (LOC661487), transcript variant X1, mRNA K11840 USP9_24 ubiquitin carboxyl-terminal hydrolase 9/24 http://www.genome.jp/dbget-bin/www_bget?ko:K11840 P70398 6863 0.0e+00 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Mus musculus GN=Usp9x PE=1 SV=2 PF11093//PF00443 Mitochondrial export protein Som1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG1866 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.39120 BP_3 33.76 1.66 1270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39121 BP_3 2.00 0.34 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39122 BP_3 1673.97 41.91 2217 546678047 ERL88771.1 2194 5.6e-244 hypothetical protein D910_06153 [Dendroctonus ponderosae] -- -- -- -- -- K01277 DPP3 dipeptidyl-peptidase III http://www.genome.jp/dbget-bin/www_bget?ko:K01277 Q9VHR8 1550 1.1e-170 Dipeptidyl peptidase 3 OS=Drosophila melanogaster GN=DppIII PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3675 Dipeptidyl peptidase III Cluster-8309.39123 BP_3 925.27 7.20 6489 642924534 XP_008194335.1 2139 3.9e-237 PREDICTED: junctophilin-1 isoform X2 [Tribolium castaneum] 642924533 XM_008196113.1 493 0 PREDICTED: Tribolium castaneum junctophilin-1 (LOC662408), transcript variant X2, mRNA K19530 JPH junctophilin http://www.genome.jp/dbget-bin/www_bget?ko:K19530 Q9ET80 1235 1.1e-133 Junctophilin-1 OS=Mus musculus GN=Jph1 PE=2 SV=1 PF01022//PF06112//PF04072 Bacterial regulatory protein, arsR family//Gammaherpesvirus capsid protein//Leucine carboxyl methyltransferase GO:0006355//GO:0032259 regulation of transcription, DNA-templated//methylation GO:0008168//GO:0003700 methyltransferase activity//transcription factor activity, sequence-specific DNA binding GO:0019028//GO:0005667 viral capsid//transcription factor complex KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.39124 BP_3 38.12 0.97 2185 642924532 XP_008194334.1 1010 1.1e-106 PREDICTED: junctophilin-1 isoform X1 [Tribolium castaneum] 749744355 XM_011156377.1 145 2.44677e-67 PREDICTED: Harpegnathos saltator uncharacterized LOC105192324 (LOC105192324), mRNA K19530 JPH junctophilin http://www.genome.jp/dbget-bin/www_bget?ko:K19530 Q9GKY8 488 1.5e-47 Junctophilin-1 OS=Oryctolagus cuniculus GN=JPH1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.39125 BP_3 112.14 1.16 4948 389609327 BAM18275.1 521 1.2e-49 junctophilin [Papilio xuthus] 642924533 XM_008196113.1 85 1.2621e-33 PREDICTED: Tribolium castaneum junctophilin-1 (LOC662408), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01022 Bacterial regulatory protein, arsR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.39126 BP_3 35.64 1.32 1598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07440//PF02468 Caerin 1 protein//Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0005576//GO:0016020//GO:0009539//GO:0009523 extracellular region//membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.39128 BP_3 777.80 13.38 3093 270006832 EFA03280.1 841 6.1e-87 hypothetical protein TcasGA2_TC013215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0C1T0 155 8.8e-09 Membrane metallo-endopeptidase-like 1 OS=Rattus norvegicus GN=Mmel1 PE=1 SV=1 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.39129 BP_3 496.86 8.47 3120 270006832 EFA03280.1 841 6.1e-87 hypothetical protein TcasGA2_TC013215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0C1T0 155 8.9e-09 Membrane metallo-endopeptidase-like 1 OS=Rattus norvegicus GN=Mmel1 PE=1 SV=1 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.39130 BP_3 2260.46 14.13 8002 817062174 XP_012252727.1 8148 0.0e+00 PREDICTED: teneurin-m isoform X2 [Athalia rosae] 642919996 XM_008193938.1 1433 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 7492 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436//PF03222//PF00008 NHL repeat//Tryptophan/tyrosine permease family//EGF-like domain GO:0003333 amino acid transmembrane transport GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.39131 BP_3 345.77 21.66 1061 642932768 XP_008196975.1 563 3.6e-55 PREDICTED: uncharacterized protein LOC662560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0007178//GO:0009069//GO:0016310//GO:0032222//GO:1903818//GO:0030431 transmembrane receptor protein serine/threonine kinase signaling pathway//serine family amino acid metabolic process//phosphorylation//regulation of synaptic transmission, cholinergic//positive regulation of voltage-gated potassium channel activity//sleep GO:0034235//GO:0004675 GPI anchor binding//transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.39132 BP_3 32.42 0.75 2368 642926818 XP_001810169.2 1798 5.0e-198 PREDICTED: uncharacterized protein LOC100142170 isoform X1 [Tribolium castaneum] 642926819 XM_008196805.1 196 1.18393e-95 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096 Altered inheritance of mitochondria protein 3 GO:0051016 barbed-end actin filament capping -- -- GO:0030479 actin cortical patch -- -- Cluster-8309.39134 BP_3 483.00 67.42 637 189238710 XP_969341.2 1047 1.6e-111 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 642927019 XM_964248.3 106 3.28541e-46 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q9LJ64 197 2.4e-14 Pollen-specific leucine-rich repeat extensin-like protein 1 OS=Arabidopsis thaliana GN=PEX1 PE=2 SV=1 PF04204 Homoserine O-succinyltransferase GO:0006555//GO:0042967//GO:0019281 methionine metabolic process//acyl-carrier-protein biosynthetic process//L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine GO:0008899 homoserine O-succinyltransferase activity GO:0005737 cytoplasm -- -- Cluster-8309.39135 BP_3 925.00 60.97 1023 546676659 ERL87623.1 1544 6.1e-169 hypothetical protein D910_05014 [Dendroctonus ponderosae] 642927019 XM_964248.3 198 3.88106e-97 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q8IXT5 209 1.6e-15 RNA-binding protein 12B OS=Homo sapiens GN=RBM12B PE=1 SV=2 PF05115 Cytochrome B6-F complex subunit VI (PetL) GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.39137 BP_3 146.50 0.52 13769 270012238 EFA08686.1 2259 1.0e-250 hypothetical protein TcasGA2_TC006356 [Tribolium castaneum] 642931870 XM_008198541.1 278 1.81687e-140 PREDICTED: Tribolium castaneum protein split ends (LOC661278), transcript variant X2, mRNA -- -- -- -- Q8SX83 1148 2.8e-123 Protein split ends OS=Drosophila melanogaster GN=spen PE=1 SV=2 PF04406//PF00335//PF02532//PF16367//PF00076 Type IIB DNA topoisomerase//Tetraspanin family//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006259//GO:0015979 DNA metabolic process//photosynthesis GO:0003676//GO:0003824//GO:0005524//GO:0003677 nucleic acid binding//catalytic activity//ATP binding//DNA binding GO:0009539//GO:0009523//GO:0005694//GO:0016020//GO:0016021 photosystem II reaction center//photosystem II//chromosome//membrane//integral component of membrane KOG0112 Large RNA-binding protein (RRM superfamily) Cluster-8309.39138 BP_3 3158.93 16.25 9661 478255507 ENN75724.1 1979 2.1e-218 hypothetical protein YQE_07684, partial [Dendroctonus ponderosae] -- -- -- -- -- K17800 LETM1, MDM38 LETM1 and EF-hand domain-containing protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17800 P91927 1023 6.1e-109 LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrial OS=Drosophila melanogaster GN=Letm1 PE=2 SV=2 PF13499 EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG1043 Ca2+-binding transmembrane protein LETM1/MRS7 Cluster-8309.39139 BP_3 836.09 7.85 5425 189238186 XP_966734.2 2332 1.4e-259 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 642925605 XM_008196416.1 565 0 PREDICTED: Tribolium castaneum hippocampus abundant transcript 1 protein (LOC661725), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 6.9e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF00400//PF07690 WD domain, G-beta repeat//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.39140 BP_3 40.31 0.64 3351 478256686 ENN76868.1 920 4.5e-96 hypothetical protein YQE_06709, partial [Dendroctonus ponderosae]>gi|546685117|gb|ERL94644.1| hypothetical protein D910_11919 [Dendroctonus ponderosae] -- -- -- -- -- K00944 AK3 nucleoside-triphosphate--adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00944 Q9WTP7 622 6.7e-63 GTP:AMP phosphotransferase AK3, mitochondrial OS=Mus musculus GN=Ak3 PE=1 SV=3 PF05191 Adenylate kinase, active site lid GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0004017 adenylate kinase activity -- -- KOG3078 Adenylate kinase Cluster-8309.39141 BP_3 425.67 5.19 4245 91086991 XP_973570.1 1379 3.4e-149 PREDICTED: maspardin [Tribolium castaneum]>gi|270010508|gb|EFA06956.1| hypothetical protein TcasGA2_TC009913 [Tribolium castaneum] -- -- -- -- -- K19367 SPG21 maspardin http://www.genome.jp/dbget-bin/www_bget?ko:K19367 Q6PC62 957 1.2e-101 Maspardin OS=Danio rerio GN=spg21 PE=2 SV=1 PF13145//PF00975 PPIC-type PPIASE domain//Thioesterase domain GO:0009058 biosynthetic process GO:0016853//GO:0016788 isomerase activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.39142 BP_3 256.00 4.32 3148 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39144 BP_3 286.85 10.48 1611 642912555 XP_008200909.1 1330 6.3e-144 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X1 [Tribolium castaneum]>gi|270002604|gb|EEZ99051.1| hypothetical protein TcasGA2_TC004926 [Tribolium castaneum] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q9UG56 767 5.0e-80 Phosphatidylserine decarboxylase proenzyme OS=Homo sapiens GN=PISD PE=2 SV=4 PF02666 Phosphatidylserine decarboxylase GO:0006563//GO:0006566//GO:0008654//GO:0046486//GO:0006544 L-serine metabolic process//threonine metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//glycine metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.39145 BP_3 4.38 0.43 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39147 BP_3 878.18 6.76 6553 270003675 EFA00123.1 2706 7.1e-303 hypothetical protein TcasGA2_TC002939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R151 1145 3.0e-123 NFX1-type zinc finger-containing protein 1 OS=Mus musculus GN=Znfx1 PE=2 SV=3 PF00270//PF00004//PF01695//PF07728//PF02562//PF04851 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//PhoH-like protein//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0003677//GO:0016787//GO:0016887//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATPase activity//ATP binding -- -- KOG1807 Helicases Cluster-8309.39149 BP_3 48.17 0.41 6013 642923500 XP_008193535.1 431 4.1e-39 PREDICTED: flocculation protein FLO11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39151 BP_3 838.79 12.90 3426 91077926 XP_974115.1 1002 1.4e-105 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] 689542246 LL999048.1 56 1.15092e-17 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_scaffold0000001 K04797 pfdA, PFDN5 prefoldin alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04797 Q5RAY0 360 1.6e-32 Prefoldin subunit 5 OS=Pongo abelii GN=PFDN5 PE=2 SV=1 PF05889//PF07684//PF01370//PF00106//PF12242 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//NOTCH protein//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0007275//GO:0008152//GO:0007219//GO:0055114//GO:0030154 multicellular organismal development//metabolic process//Notch signaling pathway//oxidation-reduction process//cell differentiation GO:0016491//GO:0016740//GO:0003824//GO:0050662//GO:0000166 oxidoreductase activity//transferase activity//catalytic activity//coenzyme binding//nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.39152 BP_3 173.68 2.05 4378 91089973 XP_973833.1 4993 0.0e+00 PREDICTED: exportin-1 [Tribolium castaneum]>gi|270013547|gb|EFA09995.1| hypothetical protein TcasGA2_TC012162 [Tribolium castaneum] 462343018 APGK01035523.1 865 0 Dendroctonus ponderosae Seq01035533, whole genome shotgun sequence K14290 XPO1, CRM1 exportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14290 Q80U96 4220 0.0e+00 Exportin-1 OS=Rattus norvegicus GN=Xpo1 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008536//GO:0008565 Ran GTPase binding//protein transporter activity GO:0005643 nuclear pore KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.39153 BP_3 51.45 0.64 4176 642925010 XP_008194133.1 4674 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X3 [Tribolium castaneum] 759033712 XM_011331767.1 146 1.30955e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X1, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3842 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03293//PF03540//PF03485//PF15014//PF05236 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Transcription initiation factor TFIID 23-30kDa subunit//Arginyl tRNA synthetase N terminal domain//Ceroid-lipofuscinosis neuronal protein 5//Transcription initiation factor TFIID component TAF4 family GO:0006206//GO:0006352//GO:0006351//GO:0006144//GO:0006560//GO:0006420//GO:0006525//GO:0019083//GO:0022008 pyrimidine nucleobase metabolic process//DNA-templated transcription, initiation//transcription, DNA-templated//purine nucleobase metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//arginine metabolic process//viral transcription//neurogenesis GO:0003677//GO:0004814//GO:0000166//GO:0005524//GO:0003899 DNA binding//arginine-tRNA ligase activity//nucleotide binding//ATP binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005764//GO:0005669//GO:0005730//GO:0005737 nucleus//lysosome//transcription factor TFIID complex//nucleolus//cytoplasm KOG3635 Phosphorylase kinase Cluster-8309.39154 BP_3 4039.16 73.99 2923 642915413 XP_008190604.1 3450 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform X1 [Tribolium castaneum] 170037221 XM_001846406.1 633 0 Culex quinquefasciatus chloride channel protein 3, mRNA K05012 CLCN3_4_5 chloride channel 3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K05012 P51790 2314 3.7e-259 H(+)/Cl(-) exchange transporter 3 OS=Homo sapiens GN=CLCN3 PE=1 SV=2 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0475 Cl- channel CLC-3 and related proteins (CLC superfamily) Cluster-8309.39155 BP_3 35.63 0.92 2162 642915413 XP_008190604.1 1235 8.7e-133 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05012 CLCN3_4_5 chloride channel 3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K05012 P51791 754 2.1e-78 H(+)/Cl(-) exchange transporter 3 OS=Mus musculus GN=Clcn3 PE=1 SV=2 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0475 Cl- channel CLC-3 and related proteins (CLC superfamily) Cluster-8309.39156 BP_3 2679.83 91.78 1699 189237939 XP_001813105.1 1081 4.9e-115 PREDICTED: ras-related protein Rab-5B [Tribolium castaneum]>gi|270008253|gb|EFA04701.1| Rab-protein 5 [Tribolium castaneum] 557324471 XM_006035208.1 217 1.78949e-107 PREDICTED: Alligator sinensis RAB5B, member RAS oncogene family (RAB5B), transcript variant X2, mRNA K07889 RAB5C Ras-related protein Rab-5C http://www.genome.jp/dbget-bin/www_bget?ko:K07889 Q98932 855 3.3e-90 Ras-related protein Rab-5C OS=Gallus gallus GN=RAB5C PE=1 SV=1 PF00071//PF00025//PF04670//PF02241//PF01926//PF08477//PF03193 Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Methyl-coenzyme M reductase beta subunit, C-terminal domain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0015031//GO:0046656//GO:0007264 protein transport//folic acid biosynthetic process//small GTPase mediated signal transduction GO:0050524//GO:0005525//GO:0003924 coenzyme-B sulfoethylthiotransferase activity//GTP binding//GTPase activity -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.39157 BP_3 322.95 3.87 4310 642935850 XP_008198197.1 1025 3.9e-108 PREDICTED: protein aurora borealis [Tribolium castaneum]>gi|270013262|gb|EFA09710.1| hypothetical protein TcasGA2_TC011843 [Tribolium castaneum] 817085067 XM_012409782.1 125 6.37958e-56 PREDICTED: Athalia rosae E3 ubiquitin-protein ligase Hakai (LOC105691369), transcript variant X2, mRNA K15685 CBLL1 E3 ubiquitin-protein ligase Hakai http://www.genome.jp/dbget-bin/www_bget?ko:K15685 Q5ZHZ4 336 1.3e-29 E3 ubiquitin-protein ligase Hakai OS=Gallus gallus GN=CBLL1 PE=2 SV=1 PF14634//PF12235//PF00097//PF13639 zinc-RING finger domain//Fragile X-related 1 protein core C terminal//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0005515//GO:0046872//GO:0008270//GO:0003723 protein binding//metal ion binding//zinc ion binding//RNA binding -- -- KOG2932 E3 ubiquitin ligase involved in ubiquitination of E-cadherin complex Cluster-8309.39158 BP_3 232.42 1.01 11377 642920053 XP_008192184.1 1927 2.6e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.84878e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.8e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF03822//PF08159//PF08445//PF13508//PF00583//PF00341//PF00159//PF13673//PF03213//PF02297//PF03396 NAF domain//NUC153 domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//PDGF/VEGF domain//Pancreatic hormone peptide//Acetyltransferase (GNAT) domain//Poxvirus P35 protein//Cytochrome oxidase c subunit VIb//Poxvirus DNA-directed RNA polymerase, 35 kD subunit GO:0006206//GO:0006144//GO:0008283//GO:0040007//GO:0006351//GO:0015992//GO:0042967//GO:0006123//GO:0007165//GO:0019083 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//cell proliferation//growth//transcription, DNA-templated//proton transport//acyl-carrier-protein biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//viral transcription GO:0004129//GO:0016747//GO:0008080//GO:0005179//GO:0008083//GO:0003677//GO:0003899 cytochrome-c oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//hormone activity//growth factor activity//DNA binding//DNA-directed RNA polymerase activity GO:0005576//GO:0016020//GO:0019031//GO:0045277//GO:0005634//GO:0005730//GO:0005739 extracellular region//membrane//viral envelope//respiratory chain complex IV//nucleus//nucleolus//mitochondrion KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.39159 BP_3 143.61 1.10 6577 91091096 XP_968472.1 1886 8.6e-208 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58428 301 2.2e-25 ATP-binding cassette sub-family G member 8 OS=Rattus norvegicus GN=Abcg8 PE=2 SV=2 PF05297//PF00005//PF01061 Herpesvirus latent membrane protein 1 (LMP1)//ABC transporter//ABC-2 type transporter GO:0006200//GO:0019087 obsolete ATP catabolic process//transformation of host cell by virus GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.39160 BP_3 117.76 0.82 7186 642934549 XP_008197710.1 1789 1.7e-196 PREDICTED: axoneme-associated protein mst101(2)-like isoform X2 [Tribolium castaneum] 768421079 XM_011553033.1 246 5.81483e-123 PREDICTED: Plutella xylostella serine/threonine-protein kinase STE20-like (LOC105383024), transcript variant X3, mRNA K06068 PRKCD novel protein kinase C delta type http://www.genome.jp/dbget-bin/www_bget?ko:K06068 P83099 1470 6.7e-161 Putative protein kinase C delta type homolog OS=Drosophila melanogaster GN=Pkcdelta PE=2 SV=3 PF00433//PF07714//PF00069//PF00858 Protein kinase C terminal domain//Protein tyrosine kinase//Protein kinase domain//Amiloride-sensitive sodium channel GO:0006814//GO:0009069//GO:0006468//GO:0016310 sodium ion transport//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005272//GO:0004672//GO:0004674//GO:0005524 sodium channel activity//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.39161 BP_3 688.00 7.25 4864 270012858 EFA09306.1 375 1.0e-32 hypothetical protein TcasGA2_TC030618, partial [Tribolium castaneum] -- -- -- -- -- K07928 RAB40 Ras-related protein Rab-40 http://www.genome.jp/dbget-bin/www_bget?ko:K07928 Q8VHP8 151 4.0e-08 Ras-related protein Rab-40B OS=Mus musculus GN=Rab40b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39163 BP_3 9.93 0.61 1072 91088775 XP_967272.1 981 1.2e-103 PREDICTED: peptide methionine sulfoxide reductase [Tribolium castaneum]>gi|270011632|gb|EFA08080.1| hypothetical protein TcasGA2_TC005676 [Tribolium castaneum] -- -- -- -- -- K07304 msrA peptide-methionine (S)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07304 P08761 610 5.3e-62 Peptide methionine sulfoxide reductase OS=Drosophila melanogaster GN=Eip71CD PE=2 SV=2 PF01625 Peptide methionine sulfoxide reductase GO:0055114//GO:0006464 oxidation-reduction process//cellular protein modification process GO:0008113 peptide-methionine (S)-S-oxide reductase activity -- -- KOG1635 Peptide methionine sulfoxide reductase Cluster-8309.39165 BP_3 68.44 1.21 3021 270002093 EEZ98540.1 1018 1.8e-107 hypothetical protein TcasGA2_TC001044 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00595//PF13180//PF09297 PDZ domain (Also known as DHR or GLGF)//PDZ domain//NADH pyrophosphatase zinc ribbon domain -- -- GO:0016787//GO:0005515//GO:0046872 hydrolase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.39166 BP_3 59.00 6.02 764 -- -- -- -- -- 642918450 XM_965626.3 51 1.49254e-15 PREDICTED: Tribolium castaneum paramyosin, long form (LOC659309), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39168 BP_3 87.93 1.70 2783 642926864 XP_008195044.1 2266 3.2e-252 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum] 748585115 LC002996.1 39 2.62998e-08 Ostrinia furnacalis gene for hypothetical protein, partial cds, note: entry16 -- -- -- -- O18824 615 3.6e-62 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.39170 BP_3 3288.70 59.34 2963 91084727 XP_970450.1 2622 1.8e-293 PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|642925824|ref|XP_008190453.1| PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|270008937|gb|EFA05385.1| hypothetical protein TcasGA2_TC015557 [Tribolium castaneum] 642925825 XM_965357.2 476 0 PREDICTED: Tribolium castaneum uncharacterized LOC659018 (LOC659018), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01749 Importin beta binding domain GO:0015031//GO:0006606 protein transport//protein import into nucleus GO:0008565 protein transporter activity GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.39171 BP_3 332.00 21.13 1049 270004120 EFA00568.1 1253 3.5e-135 hypothetical protein TcasGA2_TC003438 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 1047 1.1e-112 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.39172 BP_3 78.15 6.96 833 270297202 NP_001161902.1 1021 2.2e-108 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 771 8.8e-81 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- GO:0008152 metabolic process GO:0033961 cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.39174 BP_3 140.85 1.46 4952 642939101 XP_008200222.1 1724 4.0e-189 PREDICTED: uncharacterized protein LOC658083 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 1226 9.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.39176 BP_3 5057.93 98.45 2768 546676385 ERL87407.1 403 3.3e-36 hypothetical protein D910_04802 [Dendroctonus ponderosae] 755959155 XM_011306001.1 66 2.56069e-23 PREDICTED: Fopius arisanus 60S ribosomal protein L38 (LOC105267271), mRNA K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q4GX86 339 3.6e-30 60S ribosomal protein L38 OS=Timarcha balearica GN=RpL38 PE=3 SV=1 PF11857//PF00106//PF01781 Domain of unknown function (DUF3377)//short chain dehydrogenase//Ribosomal L38e protein family GO:0042254//GO:0006412//GO:0008152 ribosome biogenesis//translation//metabolic process GO:0003735//GO:0016491//GO:0004222 structural constituent of ribosome//oxidoreductase activity//metalloendopeptidase activity GO:0005622//GO:0005840 intracellular//ribosome KOG3499 60S ribosomal protein L38 Cluster-8309.39177 BP_3 1872.06 23.05 4207 642924614 XP_008194364.1 1951 1.6e-215 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 5.8e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0003700 DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.39178 BP_3 457.23 11.73 2170 642929065 XP_008195677.1 2246 5.1e-250 PREDICTED: CCR4-NOT transcription complex subunit 10 [Tribolium castaneum]>gi|642929067|ref|XP_008195678.1| PREDICTED: CCR4-NOT transcription complex subunit 10 [Tribolium castaneum] -- -- -- -- -- K12607 CNOT10 CCR4-NOT transcription complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K12607 Q5ZIW2 768 5.1e-80 CCR4-NOT transcription complex subunit 10 OS=Gallus gallus GN=CNOT10 PE=2 SV=1 PF13176//PF08054//PF13414//PF13181//PF00515//PF13374//PF01335 Tetratricopeptide repeat//Leucine operon leader peptide//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Death effector domain GO:0009098//GO:0042981 leucine biosynthetic process//regulation of apoptotic process GO:0005515 protein binding -- -- -- -- Cluster-8309.39179 BP_3 1021.92 7.46 6895 642929799 XP_008195982.1 2636 9.8e-295 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 2-like [Tribolium castaneum] 118150627 NM_001077805.1 77 4.93255e-29 Danio rerio oxysterol binding protein-like 9 (osbpl9), mRNA >gnl|BL_ORD_ID|3545007 Danio rerio oxysterol binding protein-like 9, mRNA (cDNA clone MGC:154069 IMAGE:8338829), complete cds -- -- -- -- Q0IJ05 1299 4.3e-141 Oxysterol-binding protein-related protein 9 OS=Xenopus tropicalis GN=osbpl9 PE=2 SV=1 PF00413//PF10462//PF01562//PF05093//PF01421 Matrixin//Peptidase M66//Reprolysin family propeptide//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//Reprolysin (M12B) family zinc metalloprotease GO:0016226//GO:0006508 iron-sulfur cluster assembly//proteolysis GO:0051536//GO:0008270//GO:0004222 iron-sulfur cluster binding//zinc ion binding//metalloendopeptidase activity GO:0005737//GO:0031012 cytoplasm//extracellular matrix KOG2210 Oxysterol-binding protein Cluster-8309.3918 BP_3 10.19 0.33 1779 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39180 BP_3 165.71 3.62 2497 642916856 XP_968783.3 169 4.1e-09 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39181 BP_3 834.51 7.63 5561 546678097 ERL88806.1 2073 1.5e-229 hypothetical protein D910_06188 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.39182 BP_3 20.60 0.81 1512 91076454 XP_971838.1 304 5.5e-25 PREDICTED: ubiquitin-like protein FUBI [Tribolium castaneum]>gi|270002576|gb|EEZ99023.1| hypothetical protein TcasGA2_TC004892 [Tribolium castaneum] -- -- -- -- -- K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 Q9W6Y0 138 4.0e-07 40S ribosomal protein S30 OS=Oryzias latipes GN=fau PE=3 SV=2 PF00240//PF04758 Ubiquitin family//Ribosomal protein S30 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.39185 BP_3 657.17 3.93 8359 642926040 XP_008194740.1 10492 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 1035 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 7605 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF08326//PF02655//PF07478//PF02786 Acetyl-CoA carboxylase, central region//ATP-grasp domain//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain GO:0046436//GO:0006633//GO:0009252//GO:0006090 D-alanine metabolic process//fatty acid biosynthetic process//peptidoglycan biosynthetic process//pyruvate metabolic process GO:0005524//GO:0046872//GO:0003989//GO:0008716 ATP binding//metal ion binding//acetyl-CoA carboxylase activity//D-alanine-D-alanine ligase activity GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.39187 BP_3 28.99 0.46 3310 642923827 XP_008193896.1 1230 5.1e-132 PREDICTED: endonuclease/exonuclease/phosphatase family domain-containing protein 1-like [Tribolium castaneum]>gi|270007767|gb|EFA04215.1| hypothetical protein TcasGA2_TC014464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IND4 330 4.8e-29 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Xenopus laevis GN=eepd1 PE=2 SV=1 PF03934//PF00633 Type II secretion system (T2SS), protein K//Helix-hairpin-helix motif GO:0009306//GO:0006281 protein secretion//DNA repair GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.39188 BP_3 1437.43 38.98 2069 642939193 XP_008200375.1 661 3.0e-66 PREDICTED: cytochrome c oxidase subunit 5A, mitochondrial [Tribolium castaneum]>gi|270016379|gb|EFA12825.1| hypothetical protein TcasGA2_TC001862 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 8.4e-40 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284 Cytochrome c oxidase subunit Va GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0045277 mitochondrial inner membrane//respiratory chain complex IV KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.39190 BP_3 624.54 7.68 4211 91079776 XP_967502.1 1323 1.1e-142 PREDICTED: coiled-coil domain-containing protein 50 [Tribolium castaneum]>gi|270004516|gb|EFA00964.1| hypothetical protein TcasGA2_TC003874 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IVM0 183 6.8e-12 Coiled-coil domain-containing protein 50 OS=Homo sapiens GN=CCDC50 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39193 BP_3 1868.94 20.99 4583 332373726 AEE62004.1 428 7.0e-39 unknown [Dendroctonus ponderosae]>gi|478250918|gb|ENN71403.1| hypothetical protein YQE_11907, partial [Dendroctonus ponderosae]>gi|546684873|gb|ERL94455.1| hypothetical protein D910_11732 [Dendroctonus ponderosae] -- -- -- -- -- K03873 TCEB2 transcription elongation factor B, polypeptide 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03873 P62870 254 4.3e-20 Transcription elongation factor B polypeptide 2 OS=Rattus norvegicus GN=Tceb2 PE=1 SV=1 PF05920//PF00240//PF14560//PF00046 Homeobox KN domain//Ubiquitin family//Ubiquitin-like domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0483 Transcription factor HEX, contains HOX and HALZ domains Cluster-8309.39194 BP_3 200.97 2.54 4103 91078812 XP_970578.1 598 1.2e-58 PREDICTED: phytanoyl-CoA dioxygenase domain-containing protein 1 homolog [Tribolium castaneum]>gi|270004117|gb|EFA00565.1| hypothetical protein TcasGA2_TC003435 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRE7 351 2.2e-31 Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Homo sapiens GN=PHYHD1 PE=1 SV=2 PF04005 Hus1-like protein GO:0000077//GO:0006281 DNA damage checkpoint//DNA repair -- -- GO:0030896 checkpoint clamp complex KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.39196 BP_3 373.89 9.71 2147 642916373 XP_008190993.1 951 7.4e-100 PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum]>gi|642916375|ref|XP_008190995.1| PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q6P6R0 539 1.8e-53 Protein lifeguard 1 OS=Rattus norvegicus GN=Grina PE=2 SV=1 PF05393 Human adenovirus early E3A glycoprotein -- -- -- -- GO:0016021 integral component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.39198 BP_3 226.89 5.02 2472 642931392 XP_008196559.1 1015 3.2e-107 PREDICTED: paramyosin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39199 BP_3 4822.58 107.35 2457 642931392 XP_008196559.1 1015 3.2e-107 PREDICTED: paramyosin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39200 BP_3 1984.62 54.72 2040 478255100 ENN75330.1 2419 4.2e-270 hypothetical protein YQE_08107, partial [Dendroctonus ponderosae] -- -- -- -- -- K01890 FARSB, pheT phenylalanyl-tRNA synthetase beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K01890 Q9VCA5 2049 1.4e-228 Phenylalanine--tRNA ligase beta subunit OS=Drosophila melanogaster GN=beta-PheRS PE=1 SV=1 PF03483//PF02531//PF03484 B3/4 domain//PsaD//tRNA synthetase B5 domain GO:0015979//GO:0006432//GO:0009094//GO:0006571//GO:0000162 photosynthesis//phenylalanyl-tRNA aminoacylation//L-phenylalanine biosynthetic process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0003723//GO:0005524//GO:0004826//GO:0000287 RNA binding//ATP binding//phenylalanine-tRNA ligase activity//magnesium ion binding GO:0009522//GO:0009538//GO:0009328 photosystem I//photosystem I reaction center//phenylalanine-tRNA ligase complex KOG2472 Phenylalanyl-tRNA synthetase beta subunit Cluster-8309.39201 BP_3 15849.99 1731.24 733 -- -- -- -- -- 209571502 NM_001135910.1 85 1.79715e-34 Tribolium castaneum ribosomal protein L41 (Rpl41), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39204 BP_3 262.30 3.83 3593 91078712 XP_966534.1 1635 6.0e-179 PREDICTED: ethanolamine-phosphate cytidylyltransferase [Tribolium castaneum]>gi|270003752|gb|EFA00200.1| hypothetical protein TcasGA2_TC003025 [Tribolium castaneum] -- -- -- -- -- K00967 PCYT2 ethanolamine-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00967 Q5EA75 1228 3.9e-133 Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus GN=PCYT2 PE=2 SV=1 PF01467//PF00154//PF06574//PF02569 Cytidylyltransferase-like//recA bacterial DNA recombination protein//FAD synthetase//Pantoate-beta-alanine ligase GO:0009432//GO:0006771//GO:0019482//GO:0009058//GO:0015940//GO:0006281//GO:0009231 SOS response//riboflavin metabolic process//beta-alanine metabolic process//biosynthetic process//pantothenate biosynthetic process//DNA repair//riboflavin biosynthetic process GO:0004592//GO:0016779//GO:0003919//GO:0005524//GO:0003824//GO:0003697 pantoate-beta-alanine ligase activity//nucleotidyltransferase activity//FMN adenylyltransferase activity//ATP binding//catalytic activity//single-stranded DNA binding -- -- KOG2803 Choline phosphate cytidylyltransferase/Predicted CDP-ethanolamine synthase Cluster-8309.39206 BP_3 51.26 1.81 1654 91094771 XP_967866.1 1686 3.4e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.3e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.39208 BP_3 358.18 26.84 935 642932529 XP_008197152.1 450 4.0e-42 PREDICTED: type-1 angiotensin II receptor-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39211 BP_3 69.08 0.40 8575 642913474 XP_008201027.1 774 9.9e-79 PREDICTED: uncharacterized protein LOC664262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 531 6.1e-52 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39213 BP_3 317.77 2.22 7197 91090606 XP_973086.1 645 7.6e-64 PREDICTED: peroxisomal membrane protein PEX14 [Tribolium castaneum] -- -- -- -- -- K13343 PEX14 peroxin-14 http://www.genome.jp/dbget-bin/www_bget?ko:K13343 Q642G4 224 2.0e-16 Peroxisomal membrane protein PEX14 OS=Rattus norvegicus GN=Pex14 PE=1 SV=1 PF05008 Vesicle transport v-SNARE protein N-terminus GO:0006886 intracellular protein transport -- -- GO:0016020 membrane KOG2629 Peroxisomal membrane anchor protein (peroxin) Cluster-8309.39214 BP_3 172.07 0.85 10007 642916148 XP_008190905.1 3559 0.0e+00 PREDICTED: BAI1-associated protein 3 [Tribolium castaneum]>gi|270003708|gb|EFA00156.1| hypothetical protein TcasGA2_TC002977 [Tribolium castaneum] 642916147 XM_008192683.1 676 0 PREDICTED: Tribolium castaneum BAI1-associated protein 3 (LOC661754), mRNA K15621 BAIAP3 BAI1-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15621 O94812 905 3.1e-95 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF00168//PF06070//PF01779 C2 domain//Herpesvirus large structural phosphoprotein UL32//Ribosomal L29e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0005198//GO:0003735 protein binding//structural molecule activity//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.39215 BP_3 17.72 1.34 931 189235871 XP_001811450.1 243 4.0e-18 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39216 BP_3 43.00 1.13 2120 478255545 ENN75762.1 1819 1.6e-200 hypothetical protein YQE_07721, partial [Dendroctonus ponderosae] 665793581 XM_008546222.1 67 5.43528e-24 PREDICTED: Microplitis demolitor proton-associated sugar transporter A-like (LOC103569108), mRNA K15378 SLC45A1_2_4 solute carrier family 45, member 1/2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15378 Q9UMX9 636 1.0e-64 Membrane-associated transporter protein OS=Homo sapiens GN=SLC45A2 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0637 Sucrose transporter and related proteins Cluster-8309.39217 BP_3 184.50 2.11 4501 642934019 XP_008197606.1 1061 2.7e-112 PREDICTED: PCTP-like protein isoform X1 [Tribolium castaneum] 642934018 XM_008199384.1 192 3.79039e-93 PREDICTED: Tribolium castaneum phosphatidylcholine transfer protein (LOC662808), transcript variant X1, mRNA -- -- -- -- Q9JMD3 495 4.8e-48 PCTP-like protein OS=Mus musculus GN=Stard10 PE=1 SV=1 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.39223 BP_3 879.00 21.93 2224 91094635 XP_970093.1 1672 1.9e-183 PREDICTED: replication protein A 70 kDa DNA-binding subunit [Tribolium castaneum]>gi|270016445|gb|EFA12891.1| hypothetical protein TcasGA2_TC004405 [Tribolium castaneum] -- -- -- -- -- K07466 RFA1, RPA1, rpa replication factor A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07466 Q24492 1460 3.0e-160 Replication protein A 70 kDa DNA-binding subunit OS=Drosophila melanogaster GN=RpA-70 PE=1 SV=1 PF01428//PF04057//PF01336 AN1-like Zinc finger//Replication factor-A protein 1, N-terminal domain//OB-fold nucleic acid binding domain GO:0006260 DNA replication GO:0003677//GO:0003676//GO:0008270 DNA binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus KOG0851 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins Cluster-8309.39226 BP_3 126.75 1.33 4882 642934681 XP_008197767.1 4375 0.0e+00 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X5 [Tribolium castaneum] 642934684 XM_008199547.1 110 1.57687e-47 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1560 1.7e-171 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF02542//PF00211 YgbB family//Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0016114//GO:0009190 intracellular signal transduction//terpenoid biosynthetic process//cyclic nucleotide biosynthetic process GO:0008685//GO:0016849 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity//phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.39227 BP_3 1542.02 14.91 5278 557777952 XP_005188609.1 1007 5.8e-106 PREDICTED: 4-coumarate--CoA ligase 1 [Musca domestica] -- -- -- -- -- -- -- -- -- Q27757 859 3.5e-90 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF03283//PF00501//PF05924 Pectinacetylesterase//AMP-binding enzyme//SAMP Motif GO:0008152//GO:0016055 metabolic process//Wnt signaling pathway GO:0003824//GO:0008013//GO:0016787 catalytic activity//beta-catenin binding//hydrolase activity GO:0016342 catenin complex KOG1176 Acyl-CoA synthetase Cluster-8309.39228 BP_3 141.37 3.39 2301 270016491 EFA12937.1 319 1.5e-26 hypothetical protein TcasGA2_TC010484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CUX1 178 1.4e-11 52 kDa repressor of the inhibitor of the protein kinase OS=Mus musculus GN=Prkrir PE=2 SV=2 PF03854 P-11 zinc finger -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.39229 BP_3 153.93 1.14 6781 91083759 XP_971689.1 2098 2.3e-232 PREDICTED: translocation protein SEC63 homolog [Tribolium castaneum] 241591921 XM_002403988.1 183 5.7639e-88 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 1436 5.6e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF06414//PF05470//PF00973//PF01591 Zeta toxin//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Paramyxovirus nucleocapsid protein//6-phosphofructo-2-kinase GO:0006413//GO:0006013//GO:0006000//GO:0006446 translational initiation//mannose metabolic process//fructose metabolic process//regulation of translational initiation GO:0031369//GO:0016301//GO:0005524//GO:0003743//GO:0003873//GO:0005198 translation initiation factor binding//kinase activity//ATP binding//translation initiation factor activity//6-phosphofructo-2-kinase activity//structural molecule activity GO:0005840//GO:0005852//GO:0019013 ribosome//eukaryotic translation initiation factor 3 complex//viral nucleocapsid KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.3923 BP_3 2.00 0.61 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39232 BP_3 23.00 0.58 2200 827539582 XP_012552934.1 177 4.3e-10 PREDICTED: transcription factor Ken 1-like [Bombyx mori] -- -- -- -- -- -- -- -- -- Q7KQZ4 158 2.8e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF12678//PF02892//PF16622//PF00096 RING-H2 zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.39233 BP_3 31.50 0.62 2750 478253163 ENN73534.1 190 1.7e-11 hypothetical protein YQE_09785, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF01700 Zinc finger, C2H2 type//Zinc-finger double domain//Orbivirus VP3 (T2) protein -- -- GO:0046872//GO:0005198 metal ion binding//structural molecule activity -- -- -- -- Cluster-8309.39235 BP_3 29.48 0.37 4113 646719839 KDR21809.1 201 1.3e-12 hypothetical protein L798_02611, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q7KQZ4 161 2.4e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39237 BP_3 245.40 15.64 1048 255522805 NP_001157315.1 721 1.7e-73 longitudinals lacking isoform 6 [Tribolium castaneum] 255522808 NM_001163845.1 254 2.94824e-128 Tribolium castaneum longitudinals lacking (Lola), transcript variant 8, mRNA -- -- -- -- -- -- -- -- PF16622//PF00643//PF13912//PF01785//PF13465//PF02701//PF00096 zinc-finger C2H2-type//B-box zinc finger//C2H2-type zinc finger//Closterovirus coat protein//Zinc-finger double domain//Dof domain, zinc finger//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0019012//GO:0005622 virion//intracellular KOG1721 FOG: Zn-finger Cluster-8309.39238 BP_3 26.00 2.78 742 13625795 AAK35160.1 312 3.2e-26 defensin 1 precursor [Acalolepta luxuriosa] -- -- -- -- -- -- -- -- -- Q27023 225 1.6e-17 Tenecin-1 OS=Tenebrio molitor PE=1 SV=1 PF01097 Arthropod defensin GO:0006952 defense response -- -- -- -- -- -- Cluster-8309.39240 BP_3 183.03 2.26 4196 642918534 XP_008191512.1 522 8.1e-50 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 118 4.83425e-52 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA K17531 OBSCN Obscurin-RhoGEF http://www.genome.jp/dbget-bin/www_bget?ko:K17531 O01761 190 1.0e-12 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39244 BP_3 1630.04 22.96 3713 189234829 XP_001811696.1 2830 0.0e+00 PREDICTED: protein fem-1 homolog CG6966 isoform X1 [Tribolium castaneum]>gi|270001481|gb|EEZ97928.1| hypothetical protein TcasGA2_TC000315 [Tribolium castaneum] 751210065 XM_011159411.1 167 2.46479e-79 PREDICTED: Solenopsis invicta protein fem-1 homolog CG6966 (LOC105194484), transcript variant X1, mRNA -- -- -- -- Q9VFD5 1761 6.3e-195 Protein fem-1 homolog CG6966 OS=Drosophila melanogaster GN=CG6966 PE=2 SV=2 PF00023//PF13606//PF13374 Ankyrin repeat//Ankyrin repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.39245 BP_3 33.17 2.43 950 546683453 ERL93259.1 1219 2.7e-131 hypothetical protein D910_10555 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 258 3.1e-21 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF16656//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.39247 BP_3 9.09 0.39 1414 642928238 XP_008195500.1 410 2.6e-37 PREDICTED: uncharacterized protein LOC103313603 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06581 Mad1 and Cdc20-bound-Mad2 binding GO:0007096 regulation of exit from mitosis -- -- GO:0005634 nucleus -- -- Cluster-8309.39248 BP_3 157.33 1.76 4590 642926793 XP_008195018.1 3653 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 47 1.55708e-12 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2149 7.9e-240 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF13606//PF00023//PF00651//PF01068 Ankyrin repeat//Ankyrin repeat//BTB/POZ domain//ATP dependent DNA ligase domain GO:0006281//GO:0006260//GO:0006310 DNA repair//DNA replication//DNA recombination GO:0003910//GO:0005515//GO:0005524 DNA ligase (ATP) activity//protein binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.3925 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39250 BP_3 2936.89 7.33 19593 642937892 XP_008200345.1 18830 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 3.5658e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 10409 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF01667//PF03488//PF02806//PF04410//PF03875//PF02207 Ribosomal protein S27//Nematode insulin-related peptide beta type//Alpha amylase, C-terminal all-beta domain//Gar1/Naf1 RNA binding region//Statherin//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0030500//GO:0007165//GO:0042742//GO:0042254//GO:0001522//GO:0005975 translation//regulation of bone mineralization//signal transduction//defense response to bacterium//ribosome biogenesis//pseudouridine synthesis//carbohydrate metabolic process GO:0005179//GO:0003824//GO:0043169//GO:0046848//GO:0008270//GO:0003735 hormone activity//catalytic activity//cation binding//hydroxyapatite binding//zinc ion binding//structural constituent of ribosome GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1776 Zn-binding protein Push Cluster-8309.39251 BP_3 129.06 1.14 5772 270004122 EFA00570.1 298 1.0e-23 hypothetical protein TcasGA2_TC003440 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.39252 BP_3 2624.68 11.74 11065 642934315 XP_008198597.1 2307 2.2e-256 PREDICTED: integrin alpha-PS2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 1766 4.9e-195 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF05375//PF15686 Pacifastin inhibitor (LCMII)//Lysine-rich CEACAM1 co-isolated protein family GO:0045766//GO:0043066//GO:0043123 positive regulation of angiogenesis//negative regulation of apoptotic process//positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.39254 BP_3 160.75 2.49 3399 270016569 EFA13015.1 3551 0.0e+00 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] 831318133 XM_012836335.1 35 5.38777e-06 PREDICTED: Clupea harengus low density lipoprotein receptor-related protein 2 (lrp2), mRNA -- -- -- -- P98165 1668 3.5e-184 Very low-density lipoprotein receptor OS=Gallus gallus GN=VLDLR PE=1 SV=1 PF08506//PF00002//PF00057//PF07645 Cse1//7 transmembrane receptor (Secretin family)//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain GO:0006886//GO:0007186 intracellular protein transport//G-protein coupled receptor signaling pathway GO:0005515//GO:0005509//GO:0004930 protein binding//calcium ion binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.39255 BP_3 3525.68 30.96 5780 546682882 ERL92768.1 2101 8.9e-233 hypothetical protein D910_10076 [Dendroctonus ponderosae] -- -- -- -- -- K17785 IMMT, FCJ1, MNOS2 mitofilin http://www.genome.jp/dbget-bin/www_bget?ko:K17785 P91928 1217 1.2e-131 MICOS complex subunit Mic60 OS=Drosophila melanogaster GN=Mitofilin PE=1 SV=4 PF01557//PF01632//PF09074 Fumarylacetoacetate (FAA) hydrolase family//Ribosomal protein L35//Mer2 GO:0008152//GO:0006412//GO:0007131//GO:0042254 metabolic process//translation//reciprocal meiotic recombination//ribosome biogenesis GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0000794//GO:0005840//GO:0005622 condensed nuclear chromosome//ribosome//intracellular KOG1854 Mitochondrial inner membrane protein (mitofilin) Cluster-8309.39256 BP_3 476.30 9.65 2670 91078460 XP_967570.1 1377 3.7e-149 PREDICTED: tether containing UBX domain for GLUT4-like [Tribolium castaneum] -- -- -- -- -- K15627 ASPSCR1, ASPL tether containing UBX domain for GLUT4 http://www.genome.jp/dbget-bin/www_bget?ko:K15627 Q9BZE9 550 1.2e-54 Tether containing UBX domain for GLUT4 OS=Homo sapiens GN=ASPSCR1 PE=1 SV=1 PF02196//PF00789 Raf-like Ras-binding domain//UBX domain GO:0007165 signal transduction GO:0005057//GO:0005515 receptor signaling protein activity//protein binding -- -- KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.39257 BP_3 35.78 0.31 5874 546675155 ERL86391.1 1444 1.4e-156 hypothetical protein D910_03799 [Dendroctonus ponderosae] -- -- -- -- -- K14859 SSF1_2 ribosome biogenesis protein SSF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14859 Q9VDE5 984 1.2e-104 Protein Peter pan OS=Drosophila melanogaster GN=ppan PE=1 SV=1 PF02384//PF13181//PF05944//PF14863//PF08241//PF01555//PF13371//PF03602//PF00515//PF02614//PF13867//PF02086//PF13414//PF14721 N-6 DNA Methylase//Tetratricopeptide repeat//Phage small terminase subunit//Alkyl sulfatase dimerisation//Methyltransferase domain//DNA methylase//Tetratricopeptide repeat//Conserved hypothetical protein 95//Tetratricopeptide repeat//Glucuronate isomerase//Sin3 binding region of histone deacetylase complex subunit SAP30//D12 class N6 adenine-specific DNA methyltransferase//TPR repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term GO:0019069//GO:0006306//GO:0032775//GO:0008152//GO:0006064//GO:0031167 viral capsid assembly//DNA methylation//DNA methylation on adenine//metabolic process//glucuronate catabolic process//rRNA methylation GO:0008168//GO:0008170//GO:0009007//GO:0004519//GO:0003677//GO:0046983//GO:0008880//GO:0005515 methyltransferase activity//N-methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//endonuclease activity//DNA binding//protein dimerization activity//glucuronate isomerase activity//protein binding -- -- KOG2963 RNA-binding protein required for 60S ribosomal subunit biogenesis Cluster-8309.39258 BP_3 407.79 2.59 7889 642918117 XP_008194070.1 5241 0.0e+00 PREDICTED: ALK tyrosine kinase receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 1482 3.0e-162 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 PF00629//PF00069//PF07714//PF00057 MAM domain, meprin/A5/mu//Protein kinase domain//Protein tyrosine kinase//Low-density lipoprotein receptor domain class A GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity GO:0016020 membrane KOG1095 Protein tyrosine kinase Cluster-8309.39262 BP_3 1102.24 9.01 6191 642930820 XP_008196102.1 3934 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.26658e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q6GPD0 1258 2.2e-136 Rho GTPase-activating protein 32 OS=Xenopus laevis GN=arhgap32 PE=2 SV=1 PF01929//PF14604//PF00018//PF00620//PF00787 Ribosomal protein L14//Variant SH3 domain//SH3 domain//RhoGAP domain//PX domain GO:0042254//GO:0007154//GO:0006412//GO:0007165 ribosome biogenesis//cell communication//translation//signal transduction GO:0003735//GO:0005515//GO:0035091 structural constituent of ribosome//protein binding//phosphatidylinositol binding GO:0005622//GO:0005840 intracellular//ribosome KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.39263 BP_3 89.02 6.63 939 728418014 AIY68354.1 746 1.9e-76 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39264 BP_3 1582.99 63.57 1492 662193280 XP_008469540.1 1298 3.0e-140 PREDICTED: succinyl-CoA ligase subunit alpha, mitochondrial [Diaphorina citri] 754347720 XM_004347817.2 102 1.32795e-43 Capsaspora owczarzaki ATCC 30864 succinate-CoA ligase mRNA K01899 LSC1 succinyl-CoA synthetase alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01899 Q94522 1186 1.2e-128 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Drosophila melanogaster GN=Scsalpha PE=2 SV=3 PF00549//PF02629//PF13380 CoA-ligase//CoA binding domain//CoA binding domain GO:0008152 metabolic process GO:0003824//GO:0048037 catalytic activity//cofactor binding -- -- KOG1255 Succinyl-CoA synthetase, alpha subunit Cluster-8309.39265 BP_3 4454.65 44.52 5115 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 1.00172e-39 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 2.2e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF08534//PF01496//PF00578//PF03099//PF10417 Redoxin//V-type ATPase 116kDa subunit family//AhpC/TSA family//Biotin/lipoate A/B protein ligase family//C-terminal domain of 1-Cys peroxiredoxin GO:0015991//GO:0006464//GO:0055114//GO:0015992 ATP hydrolysis coupled proton transport//cellular protein modification process//oxidation-reduction process//proton transport GO:0016491//GO:0051920//GO:0015078//GO:0016209 oxidoreductase activity//peroxiredoxin activity//hydrogen ion transmembrane transporter activity//antioxidant activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.39266 BP_3 120.41 2.56 2559 728417098 AIY68333.1 930 2.4e-97 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 555 3.0e-55 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.39268 BP_3 889.47 16.07 2959 642917848 XP_008191311.1 874 8.7e-91 PREDICTED: serine/threonine-protein kinase MARK2 isoform X9 [Tribolium castaneum] 602660707 XM_007435954.1 79 1.62572e-30 PREDICTED: Python bivittatus MAP/microtubule affinity-regulating kinase 1 (MARK1), transcript variant X5, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 O08678 506 1.7e-49 Serine/threonine-protein kinase MARK1 OS=Rattus norvegicus GN=Mark1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0586 Serine/threonine protein kinase Cluster-8309.39270 BP_3 42.40 2.64 1067 642910841 XP_008193430.1 271 2.6e-21 PREDICTED: bolA-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CEI1 196 5.3e-14 BolA-like protein 3 OS=Mus musculus GN=Bola3 PE=3 SV=1 PF02445 Quinolinate synthetase A protein GO:0009435 NAD biosynthetic process GO:0008987//GO:0051539 quinolinate synthetase A activity//4 iron, 4 sulfur cluster binding GO:0019804 obsolete quinolinate synthetase complex KOG3348 BolA (bacterial stress-induced morphogen)-related protein Cluster-8309.39271 BP_3 9.00 0.43 1299 642919915 XP_008192123.1 1014 2.2e-107 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9K8 222 6.3e-17 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0507 CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain Cluster-8309.39272 BP_3 13.30 0.39 1923 91076308 XP_969307.1 2263 4.9e-252 PREDICTED: furin-like protease 2 [Tribolium castaneum] 817211511 XM_012426473.1 448 0 PREDICTED: Orussus abietinus furin-like protease 2 (LOC105700544), mRNA K08672 PCSK6 proprotein convertase subtilisin/kexin type 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08672 P30432 2002 3.7e-223 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3525 Subtilisin-like proprotein convertase Cluster-8309.39273 BP_3 11.28 0.37 1775 270002486 EEZ98933.1 1348 5.7e-146 hypothetical protein TcasGA2_TC004554 [Tribolium castaneum] 749758627 XM_011142875.1 143 2.56152e-66 PREDICTED: Harpegnathos saltator furin-like protease 2 (LOC105184226), transcript variant X4, mRNA -- -- -- -- P30432 917 2.2e-97 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00757//PF01483 Furin-like cysteine rich region//Proprotein convertase P-domain GO:0006468//GO:0007169//GO:0006508 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway//proteolysis GO:0004252//GO:0004714//GO:0005524 serine-type endopeptidase activity//transmembrane receptor protein tyrosine kinase activity//ATP binding GO:0016020 membrane KOG3525 Subtilisin-like proprotein convertase Cluster-8309.39274 BP_3 8.00 7.13 339 546685745 ERL95200.1 333 5.4e-29 hypothetical protein D910_12468 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39275 BP_3 6.65 0.53 896 478258777 ENN78800.1 258 7.0e-20 hypothetical protein YQE_04737, partial [Dendroctonus ponderosae]>gi|546678780|gb|ERL89332.1| hypothetical protein D910_06704 [Dendroctonus ponderosae] 42764849 AY439820.1 48 8.19977e-14 Armigeres subalbatus ASAP ID: 40029 barrier-to-autointegration factor mRNA sequence -- -- -- -- Q9VLU0 217 1.6e-16 Barrier-to-autointegration factor OS=Drosophila melanogaster GN=baf PE=3 SV=1 PF02961 Barrier to autointegration factor -- -- GO:0003677 DNA binding -- -- KOG4233 DNA-bridging protein BAF Cluster-8309.39277 BP_3 27.43 0.76 2025 478257950 ENN78088.1 1286 1.0e-138 hypothetical protein YQE_05242, partial [Dendroctonus ponderosae] -- -- -- -- -- K14805 DDX24, MAK5 ATP-dependent RNA helicase DDX24/MAK5 http://www.genome.jp/dbget-bin/www_bget?ko:K14805 Q9ESV0 677 1.7e-69 ATP-dependent RNA helicase DDX24 OS=Mus musculus GN=Ddx24 PE=1 SV=2 PF08040//PF00270//PF06955 MNLL subunit//DEAD/DEAH box helicase//Xyloglucan endo-transglycosylase (XET) C-terminus GO:0006118//GO:0006073 obsolete electron transport//cellular glucan metabolic process GO:0005524//GO:0003954//GO:0003676//GO:0016762 ATP binding//NADH dehydrogenase activity//nucleic acid binding//xyloglucan:xyloglucosyl transferase activity GO:0005618//GO:0048046//GO:0005739 cell wall//apoplast//mitochondrion KOG0347 RNA helicase Cluster-8309.39278 BP_3 890.73 82.52 812 546681806 ERL91832.1 591 1.6e-58 hypothetical protein D910_09157 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379//PF03938 Insect cuticle protein//Outer membrane protein (OmpH-like) -- -- GO:0042302//GO:0051082 structural constituent of cuticle//unfolded protein binding -- -- -- -- Cluster-8309.39279 BP_3 2869.21 15.42 9259 642911235 XP_008199694.1 6755 0.0e+00 PREDICTED: laminin subunit beta-1 [Tribolium castaneum] 198455549 XM_001360008.2 44 1.46655e-10 Drosophila pseudoobscura pseudoobscura GA20347 (Dpse\GA20347), partial mRNA K05636 LAMB1 laminin, beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05636 P11046 4487 0.0e+00 Laminin subunit beta-1 OS=Drosophila melanogaster GN=LanB1 PE=1 SV=4 PF01133//PF05384//PF00874//PF10440//PF05007//PF00089//PF03554 Enhancer of rudimentary//Sensor protein DegS//PRD domain//Ubiquitin-binding WIYLD domain//Mannosyltransferase (PIG-M)//Trypsin//UL73 viral envelope glycoprotein GO:0007165//GO:0006221//GO:0045747//GO:0007049//GO:0006554//GO:0006355//GO:0006479//GO:0006506//GO:0006508 signal transduction//pyrimidine nucleotide biosynthetic process//positive regulation of Notch signaling pathway//cell cycle//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation//GPI anchor biosynthetic process//proteolysis GO:0016758//GO:0018024//GO:0004252//GO:0016301 transferase activity, transferring hexosyl groups//histone-lysine N-methyltransferase activity//serine-type endopeptidase activity//kinase activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0994 Extracellular matrix glycoprotein Laminin subunit beta Cluster-8309.39281 BP_3 1.00 0.68 359 83658844 ABC40572.1 137 3.0e-06 putative antimicrobial knottin protein Btk-4 [Bemisia tabaci] -- -- -- -- -- -- -- -- -- P83653 205 1.6e-15 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.39282 BP_3 110.93 1.75 3346 270001607 EEZ98054.1 1648 1.7e-180 hypothetical protein TcasGA2_TC000459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K1C7 300 1.5e-25 Monocarboxylate transporter 14 OS=Mus musculus GN=Slc16a14 PE=2 SV=1 PF07690//PF02308 Major Facilitator Superfamily//MgtC family GO:0055085 transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.39284 BP_3 237.55 1.34 8837 270001798 EEZ98245.1 3602 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 469 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q14554 162 3.9e-09 Protein disulfide-isomerase A5 OS=Homo sapiens GN=PDIA5 PE=1 SV=1 PF02020//PF01791//PF00085//PF02382//PF07689//PF00578 eIF4-gamma/eIF5/eIF2-epsilon//DeoC/LacD family aldolase//Thioredoxin//RTX N-terminal domain//KaiB domain//AhpC/TSA family GO:0048511//GO:0009405//GO:0045454//GO:0055114 rhythmic process//pathogenesis//cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0005515//GO:0016209//GO:0005509//GO:0016829 oxidoreductase activity//protein binding//antioxidant activity//calcium ion binding//lyase activity GO:0005576 extracellular region KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.39285 BP_3 5526.30 105.77 2810 642933110 XP_008197262.1 1355 1.4e-146 PREDICTED: prominin-like protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 398 5.3e-37 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF04513//PF01442//PF07926//PF05478//PF07464//PF13903 Baculovirus polyhedron envelope protein, PEP, C terminus//Apolipoprotein A1/A4/E domain//TPR/MLP1/MLP2-like protein//Prominin//Apolipophorin-III precursor (apoLp-III)//PMP-22/EMP/MP20/Claudin tight junction GO:0006606//GO:0042157//GO:0006869 protein import into nucleus//lipoprotein metabolic process//lipid transport GO:0008289//GO:0005198 lipid binding//structural molecule activity GO:0005576//GO:0019028//GO:0016021//GO:0019031 extracellular region//viral capsid//integral component of membrane//viral envelope KOG4331 Polytopic membrane protein Prominin Cluster-8309.39286 BP_3 258.34 7.71 1907 91093829 XP_969227.1 1839 7.1e-203 PREDICTED: transmembrane protein 161B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C2L6 1009 5.1e-108 Transmembrane protein 161B OS=Mus musculus GN=Tmem161b PE=2 SV=1 PF04632//PF00336 Fusaric acid resistance protein family//DNA polymerase (viral) C-terminal domain GO:0006810//GO:0051252 transport//regulation of RNA metabolic process GO:0004523 RNA-DNA hybrid ribonuclease activity GO:0005886 plasma membrane KOG3978 Predicted membrane protein Cluster-8309.39288 BP_3 2655.89 18.87 7074 270005756 EFA02204.1 1196 9.5e-128 hypothetical protein TcasGA2_TC007862 [Tribolium castaneum] 642919215 XM_963943.3 252 2.64422e-126 PREDICTED: Tribolium castaneum uncharacterized LOC657485 (LOC657485), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39289 BP_3 578.16 63.44 731 270009349 EFA05797.1 614 3.0e-61 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 320 1.5e-28 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.39290 BP_3 2871.96 26.41 5533 270009349 EFA05797.1 798 1.1e-81 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 463 3.0e-44 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.39291 BP_3 152.74 0.70 10770 642910658 XP_008200046.1 10281 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.39292 BP_3 174.72 1.77 5047 642910281 XP_008198657.1 720 1.1e-72 PREDICTED: prolyl 3-hydroxylase 1-like [Tribolium castaneum] -- -- -- -- -- K08134 LEPRE leucine proline-enriched proteoglycan (leprecan) http://www.genome.jp/dbget-bin/www_bget?ko:K08134 Q3V1T4 315 4.0e-27 Prolyl 3-hydroxylase 1 OS=Mus musculus GN=Lepre1 PE=2 SV=2 PF00515 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.39293 BP_3 1381.11 16.73 4270 -- -- -- -- -- 642918185 XM_008193179.1 85 1.08789e-33 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39294 BP_3 7810.93 38.17 10154 642932320 XP_008197063.1 11376 0.0e+00 PREDICTED: unconventional myosin-XV [Tribolium castaneum] 642932319 XM_008198841.1 537 0 PREDICTED: Tribolium castaneum myosin 15 (LOC658144), mRNA K10361 MYO15 myosin XV http://www.genome.jp/dbget-bin/www_bget?ko:K10361 Q9UKN7 2051 4.0e-228 Unconventional myosin-XV OS=Homo sapiens GN=MYO15A PE=1 SV=2 PF00063//PF00784//PF00612 Myosin head (motor domain)//MyTH4 domain//IQ calmodulin-binding motif -- -- GO:0005524//GO:0003774//GO:0005515 ATP binding//motor activity//protein binding GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.39295 BP_3 14.81 0.64 1406 91076492 XP_972907.1 632 4.7e-63 PREDICTED: 60S ribosomal protein L18a [Tribolium castaneum]>gi|270002411|gb|EEZ98858.1| hypothetical protein TcasGA2_TC004468 [Tribolium castaneum] 815769202 XM_012379287.1 128 4.39988e-58 PREDICTED: Linepithema humile 60S ribosomal protein L18a (LOC105679340), mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q8WQI7 587 3.2e-59 60S ribosomal protein L18a OS=Spodoptera frugiperda GN=RpL18A PE=2 SV=1 PF01775//PF09004 Ribosomal L18ae/LX protein domain//Domain of unknown function (DUF1891) GO:0006412//GO:0042254//GO:0055114 translation//ribosome biogenesis//oxidation-reduction process GO:0016706//GO:0008168//GO:0003735 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//methyltransferase activity//structural constituent of ribosome GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.39297 BP_3 11.33 0.40 1646 642921101 XP_975194.2 735 6.3e-75 PREDICTED: something about silencing protein 10 [Tribolium castaneum] -- -- -- -- -- K14767 UTP3, SAS10 U3 small nucleolar RNA-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14767 Q9I7W5 303 3.2e-26 Something about silencing protein 10 OS=Drosophila melanogaster GN=Sas10 PE=1 SV=2 PF04931//PF03165 DNA polymerase phi//MH1 domain GO:0006355//GO:0006351//GO:0006260 regulation of transcription, DNA-templated//transcription, DNA-templated//DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0005622//GO:0042575 intracellular//DNA polymerase complex KOG3118 Disrupter of silencing SAS10 Cluster-8309.39298 BP_3 129.98 3.82 1930 270002493 EEZ98940.1 798 3.7e-82 hypothetical protein TcasGA2_TC004563 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IX12 603 6.2e-61 Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens GN=CCAR1 PE=1 SV=2 PF06495//PF01247//PF02724//PF03153 Fruit fly transformer protein//Ribosomal protein L35Ae//CDC45-like protein//Transcription factor IIA, alpha/beta subunit GO:0006270//GO:0006412//GO:0006397//GO:0042254//GO:0046660//GO:0006367 DNA replication initiation//translation//mRNA processing//ribosome biogenesis//female sex differentiation//transcription initiation from RNA polymerase II promoter GO:0003735 structural constituent of ribosome GO:0005634//GO:0005622//GO:0005672//GO:0005840 nucleus//intracellular//transcription factor TFIIA complex//ribosome -- -- Cluster-8309.39299 BP_3 148.78 1.49 5102 642912125 XP_008200817.1 847 2.0e-87 PREDICTED: cell division cycle and apoptosis regulator protein 1-like [Tribolium castaneum] 572309672 XM_006620560.1 86 3.61912e-34 PREDICTED: Apis dorsata cell division cycle and apoptosis regulator protein 1-like (LOC102677857), transcript variant X2, mRNA -- -- -- -- Q8CH18 421 2.1e-39 Cell division cycle and apoptosis regulator protein 1 OS=Mus musculus GN=Ccar1 PE=1 SV=1 PF06422 CDR ABC transporter GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG4246 Predicted DNA-binding protein, contains SAP domain Cluster-8309.39300 BP_3 3356.72 81.13 2286 167234457 NP_001107844.1 1522 4.8e-166 eukaryotic translation initiation factor 5 [Tribolium castaneum]>gi|642919625|ref|XP_008191995.1| PREDICTED: eukaryotic translation initiation factor 5 isoform X1 [Tribolium castaneum]>gi|270005452|gb|EFA01900.1| hypothetical protein TcasGA2_TC007510 [Tribolium castaneum] 167234456 NM_001114372.1 159 4.22643e-75 Tribolium castaneum eukaryotic translation initiation factor 5 (Eif5), mRNA K03262 EIF5 translation initiation factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03262 Q9VXK6 1299 1.4e-141 Eukaryotic translation initiation factor 5 OS=Drosophila melanogaster GN=eIF5 PE=1 SV=1 PF02020//PF14489//PF01873 eIF4-gamma/eIF5/eIF2-epsilon//QueF-like protein//Domain found in IF2B/IF5 GO:0044238//GO:0006413//GO:0006446//GO:0008616//GO:0044260 primary metabolic process//translational initiation//regulation of translational initiation//queuosine biosynthetic process//cellular macromolecule metabolic process GO:0033739//GO:0005515//GO:0003743 preQ1 synthase activity//protein binding//translation initiation factor activity GO:0005840 ribosome KOG2767 Translation initiation factor 5 (eIF-5) Cluster-8309.39301 BP_3 545.89 17.13 1828 478259294 ENN79196.1 2111 1.9e-234 hypothetical protein YQE_04380, partial [Dendroctonus ponderosae]>gi|546681735|gb|ERL91767.1| hypothetical protein D910_09093 [Dendroctonus ponderosae] 826415366 XM_012666952.1 54 7.87692e-17 PREDICTED: Monomorium pharaonis ABC transporter G family member 20 (LOC105828568), transcript variant X3, mRNA -- -- -- -- Q8T674 387 6.5e-36 ABC transporter G family member 20 OS=Dictyostelium discoideum GN=abcG20 PE=3 SV=1 PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.39302 BP_3 127.21 0.76 8402 646715813 KDR19281.1 1054 3.3e-111 Schwannomin-interacting protein 1 [Zootermopsis nevadensis] 642924593 XM_008196134.1 241 4.09489e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.6e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.39307 BP_3 380.64 6.02 3338 642935023 XP_008199910.1 1215 2.8e-130 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 770 4.6e-80 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF08925//PF11547//PF00076//PF16367 Domain of Unknown Function (DUF1907)//E3 ubiquitin ligase EDD//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676//GO:0043130 nucleic acid binding//ubiquitin binding GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.39308 BP_3 44.56 0.90 2671 91093742 XP_968935.1 555 7.6e-54 PREDICTED: gamma-glutamylcyclotransferase isoform X2 [Tribolium castaneum]>gi|270013013|gb|EFA09461.1| hypothetical protein TcasGA2_TC010677 [Tribolium castaneum] -- -- -- -- -- K00682 GGCT gamma-glutamylcyclotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00682 Q9D7X8 339 3.5e-30 Gamma-glutamylcyclotransferase OS=Mus musculus GN=Ggct PE=1 SV=1 PF08925 Domain of Unknown Function (DUF1907) -- -- -- -- GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.39311 BP_3 8950.79 60.26 7451 270004724 EFA01172.1 1927 1.7e-212 hypothetical protein TcasGA2_TC010495 [Tribolium castaneum] 642917347 XM_965116.3 424 0 PREDICTED: Tribolium castaneum MAP kinase-interacting serine/threonine-protein kinase 1 (LOC658754), transcript variant X2, mRNA K04372 MKNK, MNK MAP kinase interacting serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04372 Q9HBH9 1110 3.9e-119 MAP kinase-interacting serine/threonine-protein kinase 2 OS=Homo sapiens GN=MKNK2 PE=1 SV=3 PF12937//PF13516//PF07714//PF06293//PF00646//PF00069 F-box-like//Leucine Rich repeat//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//F-box domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0016773//GO:0005524 protein binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0607 MAP kinase-interacting kinase and related serine/threonine protein kinases Cluster-8309.39313 BP_3 888.20 46.67 1209 642912175 XP_008200838.1 822 3.8e-85 PREDICTED: heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog isoform X2 [Tribolium castaneum] 780671672 XM_011697100.1 128 3.76766e-58 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 7.5e-73 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF00313 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.39314 BP_3 917.46 27.38 1907 91088497 XP_971106.1 1588 9.0e-174 PREDICTED: hydroxysteroid dehydrogenase-like protein 2 [Tribolium castaneum]>gi|270012748|gb|EFA09196.1| hypothetical protein TcasGA2_TC005801 [Tribolium castaneum] 195430189 XM_002063103.1 51 3.82625e-15 Drosophila willistoni GK21765 (Dwil\GK21765), mRNA -- -- -- -- Q6PAY8 1225 4.6e-133 Hydroxysteroid dehydrogenase-like protein 2 OS=Xenopus laevis GN=hsdl2 PE=2 SV=1 PF00106//PF12242 short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0000166//GO:0032934//GO:0016491 nucleotide binding//sterol binding//oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.39316 BP_3 1901.85 43.42 2403 642923928 XP_008193931.1 1561 1.5e-170 PREDICTED: probable serine incorporator isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHV9 971 1.6e-103 Serine incorporator 1 OS=Bos taurus GN=SERINC1 PE=2 SV=1 PF03348 Serine incorporator (Serinc) -- -- -- -- GO:0016020 membrane KOG2592 Tumor differentially expressed (TDE) protein Cluster-8309.39317 BP_3 12.00 0.37 1870 642922960 XP_008200469.1 255 3.3e-19 PREDICTED: uncharacterized protein LOC100142444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39318 BP_3 25.00 2.09 867 91095123 XP_970890.1 503 2.7e-48 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 360 4.2e-33 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF03857//PF00106 Colicin immunity protein//short chain dehydrogenase GO:0008152//GO:0006955//GO:0030153 metabolic process//immune response//bacteriocin immunity GO:0015643//GO:0016491 toxic substance binding//oxidoreductase activity GO:0019814 immunoglobulin complex -- -- Cluster-8309.39320 BP_3 166.47 2.09 4132 642925010 XP_008194133.1 4674 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X3 [Tribolium castaneum] 759033712 XM_011331767.1 146 1.29563e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X1, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3842 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03293//PF03485//PF15014//PF02055//PF05236//PF03540 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Arginyl tRNA synthetase N terminal domain//Ceroid-lipofuscinosis neuronal protein 5//O-Glycosyl hydrolase family 30//Transcription initiation factor TFIID component TAF4 family//Transcription initiation factor TFIID 23-30kDa subunit GO:0006420//GO:0005975//GO:0006687//GO:0006525//GO:0019083//GO:0006665//GO:0022008//GO:0006206//GO:0006807//GO:0006352//GO:0006351//GO:0006144//GO:0006560 arginyl-tRNA aminoacylation//carbohydrate metabolic process//glycosphingolipid metabolic process//arginine metabolic process//viral transcription//sphingolipid metabolic process//neurogenesis//pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//DNA-templated transcription, initiation//transcription, DNA-templated//purine nucleobase metabolic process//proline metabolic process GO:0000166//GO:0004348//GO:0003899//GO:0005524//GO:0003677//GO:0004814 nucleotide binding//glucosylceramidase activity//DNA-directed RNA polymerase activity//ATP binding//DNA binding//arginine-tRNA ligase activity GO:0005764//GO:0005669//GO:0005737//GO:0005730//GO:0005634 lysosome//transcription factor TFIID complex//cytoplasm//nucleolus//nucleus KOG3635 Phosphorylase kinase Cluster-8309.39322 BP_3 392.81 4.00 5020 642924959 XP_008194115.1 2875 0.0e+00 PREDICTED: coiled-coil domain-containing protein CG32809 isoform X7 [Tribolium castaneum] 795104299 XM_012026023.1 48 4.73805e-13 PREDICTED: Vollenhovia emeryi coiled-coil domain-containing protein CG32809 (LOC105569508), mRNA -- -- -- -- Q7PQ25 1217 1.0e-131 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF07989//PF02970//PF01025//PF05507 Centrosomin N-terminal motif 1//Tubulin binding cofactor A//GrpE//Microfibril-associated glycoprotein (MAGP) GO:0007021//GO:0006457 tubulin complex assembly//protein folding GO:0051082//GO:0051087//GO:0042803//GO:0000774//GO:0015631 unfolded protein binding//chaperone binding//protein homodimerization activity//adenyl-nucleotide exchange factor activity//tubulin binding GO:0001527//GO:0045298//GO:0005815 microfibril//tubulin complex//microtubule organizing center -- -- Cluster-8309.39323 BP_3 18.51 2.27 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39324 BP_3 1315.62 35.50 2078 478256311 ENN76501.1 492 1.2e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39325 BP_3 1356.48 24.97 2910 270002395 EEZ98842.1 2020 1.1e-223 hypothetical protein TcasGA2_TC004451 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q8BX70 1076 1.3e-115 Vacuolar protein sorting-associated protein 13C OS=Mus musculus GN=Vps13c PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.39326 BP_3 1302.73 6.83 9490 642912633 XP_008200941.1 5658 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q96RL7 2271 1.2e-253 Vacuolar protein sorting-associated protein 13A OS=Homo sapiens GN=VPS13A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.39327 BP_3 195.42 1.31 7505 642934874 XP_008197845.1 2625 2.0e-293 PREDICTED: ecdysone-induced protein 75B, isoforms C/D isoform X4 [Tribolium castaneum] 443682249 KC020244.1 254 2.1693e-127 Monochamus alternatus ecdysone-induced protein 75-like protein (E75) mRNA, partial cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1308 4.3e-142 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4846 Nuclear receptor Cluster-8309.39328 BP_3 17746.05 135.18 6619 189237751 XP_001812575.1 3801 0.0e+00 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 9.8e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF00787//PF04769//PF08070 PX domain//Mating-type protein MAT alpha 1 HMG-box//DTHCT (NUC029) region GO:0007531//GO:0006265//GO:0045895 mating type determination//DNA topological change//positive regulation of mating-type specific transcription, DNA-templated GO:0035091//GO:0003677//GO:0005524//GO:0008301//GO:0003918 phosphatidylinositol binding//DNA binding//ATP binding//DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.39329 BP_3 2140.57 38.07 3002 91084907 XP_969916.1 3790 0.0e+00 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 389 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2970 0.0e+00 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911//PF00551 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain//Formyl transferase GO:0009058//GO:0055114//GO:0032259//GO:0008152 biosynthetic process//oxidation-reduction process//methylation//metabolic process GO:0016742//GO:0008168//GO:0016620//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//methyltransferase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.39332 BP_3 1004.23 27.30 2065 642915315 XP_008190568.1 2642 5.9e-296 PREDICTED: dosage compensation regulator isoform X2 [Tribolium castaneum] 195155373 XM_002018544.1 260 2.72586e-131 Drosophila persimilis GL17788 (Dper\GL17788), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1906 5.3e-212 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF04408 Helicase associated domain (HA2) -- -- GO:0004386 helicase activity -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.39334 BP_3 168.46 7.17 1424 91085783 XP_974443.1 1714 1.6e-188 PREDICTED: fumarylacetoacetase [Tribolium castaneum]>gi|270009995|gb|EFA06443.1| hypothetical protein TcasGA2_TC009325 [Tribolium castaneum] -- -- -- -- -- K01555 FAH, fahA fumarylacetoacetase http://www.genome.jp/dbget-bin/www_bget?ko:K01555 A5PKH3 1362 4.4e-149 Fumarylacetoacetase OS=Bos taurus GN=FAH PE=2 SV=1 PF09298//PF01557 Fumarylacetoacetase N-terminal//Fumarylacetoacetate (FAA) hydrolase family GO:0042207//GO:0006570//GO:0008152//GO:0009072 styrene catabolic process//tyrosine metabolic process//metabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0003824 fumarylacetoacetase activity//catalytic activity -- -- KOG2843 Fumarylacetoacetase Cluster-8309.39335 BP_3 3318.00 161.82 1280 332375733 AEE63007.1 1236 4.0e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P49638 206 4.4e-15 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39336 BP_3 1490.99 8.24 9009 646710408 KDR15927.1 1190 6.0e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.75794e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.39337 BP_3 16.00 5.18 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39338 BP_3 1688.32 54.79 1777 91079236 XP_970901.1 1361 1.8e-147 PREDICTED: tubulin-specific chaperone E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KS0 795 3.1e-83 Tubulin-specific chaperone E OS=Bos taurus GN=TBCE PE=2 SV=1 PF13855//PF00564 Leucine rich repeat//PB1 domain -- -- GO:0005515 protein binding -- -- KOG3207 Beta-tubulin folding cofactor E Cluster-8309.39339 BP_3 78.91 0.36 10969 642935792 XP_008198176.1 3966 0.0e+00 PREDICTED: nitric oxide synthase, salivary gland isoform X2 [Tribolium castaneum] 148367285 AB304919.1 233 1.49848e-115 Luciola lateralis LlNOS mRNA for nitric oxide synthase, complete cds K13240 NOS1 nitric-oxide synthase, brain http://www.genome.jp/dbget-bin/www_bget?ko:K13240 B1B557 3028 0.0e+00 Nitric oxide synthase-like protein OS=Bombyx mori GN=NSL PE=2 SV=1 PF04103//PF01040//PF00175//PF00802//PF02898//PF00667//PF10505//PF01384//PF00258//PF09570//PF00335 CD20-like family//UbiA prenyltransferase family//Oxidoreductase NAD-binding domain//Pneumovirus attachment glycoprotein G//Nitric oxide synthase, oxygenase domain//FAD binding domain//NMDA receptor-regulated gene protein 2 C-terminus//Phosphate transporter family//Flavodoxin//SinI restriction endonuclease//Tetraspanin family GO:0055114//GO:0009307//GO:0006809//GO:0006817//GO:0006308 oxidation-reduction process//DNA restriction-modification system//nitric oxide biosynthetic process//phosphate ion transport//DNA catabolic process GO:0005315//GO:0010181//GO:0004517//GO:0004659//GO:0016491//GO:0003677//GO:0009036 inorganic phosphate transmembrane transporter activity//FMN binding//nitric-oxide synthase activity//prenyltransferase activity//oxidoreductase activity//DNA binding//Type II site-specific deoxyribonuclease activity GO:0055036//GO:0016021//GO:0009359//GO:0016020//GO:0008023 virion membrane//integral component of membrane//Type II site-specific deoxyribonuclease complex//membrane//transcription elongation factor complex KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.39340 BP_3 294.59 1.31 11121 642934315 XP_008198597.1 2307 2.2e-256 PREDICTED: integrin alpha-PS2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 1766 4.9e-195 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF15686//PF05375 Lysine-rich CEACAM1 co-isolated protein family//Pacifastin inhibitor (LCMII) GO:0043066//GO:0043123//GO:0045766 negative regulation of apoptotic process//positive regulation of I-kappaB kinase/NF-kappaB signaling//positive regulation of angiogenesis GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.39342 BP_3 104.52 1.85 3009 91079957 XP_969398.1 666 1.2e-66 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6L5 146 9.5e-08 Cyclic GMP-AMP synthase OS=Mus musculus GN=Mb21d1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39344 BP_3 8.10 0.35 1404 642928554 XP_008195373.1 146 1.1e-06 PREDICTED: uncharacterized protein LOC661472 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39345 BP_3 1293.64 14.38 4629 642936873 XP_969385.2 1554 1.9e-169 PREDICTED: cdc42-interacting protein 4 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97531 566 2.9e-56 Cdc42-interacting protein 4 OS=Rattus norvegicus GN=Trip10 PE=1 SV=3 PF02185//PF00018//PF14604 Hr1 repeat//SH3 domain//Variant SH3 domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.39346 BP_3 1304.15 8.47 7711 642936871 XP_008193040.1 1572 2.6e-171 PREDICTED: formin-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RU3 725 1.8e-74 Formin-binding protein 1 OS=Homo sapiens GN=FNBP1 PE=1 SV=2 PF14604//PF00018//PF02185//PF09177//PF00816 Variant SH3 domain//SH3 domain//Hr1 repeat//Syntaxin 6, N-terminal//H-NS histone family GO:0048193//GO:0006355//GO:0007165 Golgi vesicle transport//regulation of transcription, DNA-templated//signal transduction GO:0005515//GO:0003677 protein binding//DNA binding GO:0016020//GO:0005622 membrane//intracellular KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.39347 BP_3 11.06 0.44 1490 332374794 AEE62538.1 513 3.2e-49 unknown [Dendroctonus ponderosae]>gi|546674015|gb|ERL85508.1| hypothetical protein D910_02927 [Dendroctonus ponderosae] -- -- -- -- -- K01444 AGA, aspG N4-(beta-N-acetylglucosaminyl)-L-asparaginase http://www.genome.jp/dbget-bin/www_bget?ko:K01444 Q64191 479 1.1e-46 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Mus musculus GN=Aga PE=2 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1593 Asparaginase Cluster-8309.39348 BP_3 139.45 5.18 1589 546672637 ERL84433.1 1024 1.9e-108 hypothetical protein D910_01865, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5YCC5 398 3.0e-37 Transmembrane channel-like protein 7 OS=Gallus gallus GN=Tmc7 PE=2 SV=1 PF06305//PF07810 Protein of unknown function (DUF1049)//TMC domain -- -- -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.39349 BP_3 347.17 14.69 1431 189235746 XP_967247.2 919 2.5e-96 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 522 1.1e-51 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137 Adenosine-deaminase (editase) domain GO:0006396//GO:0006807//GO:0006144 RNA processing//nitrogen compound metabolic process//purine nucleobase metabolic process GO:0004000//GO:0003723 adenosine deaminase activity//RNA binding -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.39350 BP_3 20.00 14.60 353 332374310 AEE62296.1 289 7.0e-24 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O80944 170 1.8e-11 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.39351 BP_3 181.20 3.04 3167 642917800 XP_008191291.1 861 3.0e-89 PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|642917802|ref|XP_008191292.1| PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|270004486|gb|EFA00934.1| hypothetical protein TcasGA2_TC003840 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 424 5.8e-40 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF04539//PF01353 Sigma-70 region 3//Green fluorescent protein GO:0008218//GO:0006352//GO:0055114//GO:0006355 bioluminescence//DNA-templated transcription, initiation//oxidation-reduction process//regulation of transcription, DNA-templated GO:0016491//GO:0003677//GO:0003700//GO:0016987 oxidoreductase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667 transcription factor complex KOG1577 Aldo/keto reductase family proteins Cluster-8309.39352 BP_3 1610.04 30.46 2839 642923797 XP_008193887.1 1826 3.4e-201 PREDICTED: uncharacterized protein LOC663689 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04999//PF13014//PF00013 Cell division protein FtsL//KH domain//KH domain GO:0051301//GO:0007049 cell division//cell cycle GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.39354 BP_3 230.32 5.72 2231 642917609 XP_008191278.1 1425 8.4e-155 PREDICTED: U3 small nucleolar RNA-associated protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VCY6 452 2.3e-43 U3 small nucleolar RNA-associated protein 6 homolog OS=Mus musculus GN=Utp6 PE=2 SV=1 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG2396 HAT (Half-A-TPR) repeat-containing protein Cluster-8309.39356 BP_3 638.98 5.21 6205 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.26946e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.2e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF00787//PF00620//PF00018//PF14604//PF01929 PX domain//RhoGAP domain//SH3 domain//Variant SH3 domain//Ribosomal protein L14 GO:0042254//GO:0007154//GO:0006412//GO:0007165 ribosome biogenesis//cell communication//translation//signal transduction GO:0003735//GO:0035091//GO:0005515 structural constituent of ribosome//phosphatidylinositol binding//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.39357 BP_3 132.86 4.20 1816 189235069 XP_974729.2 1603 1.6e-175 PREDICTED: nocturnin isoform X4 [Tribolium castaneum]>gi|642915409|ref|XP_008190602.1| PREDICTED: nocturnin isoform X4 [Tribolium castaneum] -- -- -- -- -- K18764 CCRN4L nocturnin http://www.genome.jp/dbget-bin/www_bget?ko:K18764 Q9UK39 748 8.9e-78 Nocturnin OS=Homo sapiens GN=CCRN4L PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.39358 BP_3 174.26 1.74 5112 642924384 XP_008194273.1 2554 2.3e-285 PREDICTED: WD repeat-containing protein 59 [Tribolium castaneum]>gi|270007891|gb|EFA04339.1| hypothetical protein TcasGA2_TC014633 [Tribolium castaneum] 195162816 XM_002022214.1 101 1.66343e-42 Drosophila persimilis GL24697 (Dper\GL24697), mRNA -- -- -- -- Q5ZLG9 1355 1.0e-147 WD repeat-containing protein 59 OS=Gallus gallus GN=WDR59 PE=2 SV=1 PF02459//PF05773//PF00324//PF00400//PF13520 Adenoviral DNA terminal protein//RWD domain//Amino acid permease//WD domain, G-beta repeat//Amino acid permease GO:0006865//GO:0055085//GO:0006810//GO:0003333//GO:0006260 amino acid transport//transmembrane transport//transport//amino acid transmembrane transport//DNA replication GO:0003677//GO:0015171//GO:0005515 DNA binding//amino acid transmembrane transporter activity//protein binding GO:0016020 membrane -- -- Cluster-8309.39362 BP_3 697.83 3.65 9496 270005159 EFA01607.1 9105 0.0e+00 hypothetical protein TcasGA2_TC007173 [Tribolium castaneum] 642920908 XM_008194389.1 1881 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7565 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00307//PF00435 Calponin homology (CH) domain//Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.39364 BP_3 489.79 4.44 5606 642934778 XP_008197804.1 5467 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein flightless-1 [Tribolium castaneum] 262305210 GQ887625.1 163 6.24783e-77 Metajapyx subterraneus voucher JapDIPLUR gelsolin mRNA, partial cds -- -- -- -- Q24020 4259 0.0e+00 Protein flightless-1 OS=Drosophila melanogaster GN=fliI PE=2 SV=1 PF13855//PF15721//PF08661//PF00560 Leucine rich repeat//Annexin-2 receptor//Replication factor A protein 3//Leucine Rich Repeat GO:0006310//GO:0006260//GO:0007165//GO:0006281 DNA recombination//DNA replication//signal transduction//DNA repair GO:0003677//GO:0004872//GO:0005515 DNA binding//receptor activity//protein binding GO:0005634 nucleus KOG0444 Cytoskeletal regulator Flightless-I (contains leucine-rich and gelsolin repeats) Cluster-8309.39367 BP_3 543.52 9.15 3155 478259909 ENN79711.1 3590 0.0e+00 hypothetical protein YQE_03768, partial [Dendroctonus ponderosae] 462367530 APGK01026876.1 80 4.8232e-31 Dendroctonus ponderosae Seq01026886, whole genome shotgun sequence K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q01484 2721 2.6e-306 Ankyrin-2 OS=Homo sapiens GN=ANK2 PE=1 SV=4 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.39368 BP_3 152.29 5.47 1634 642930878 XP_008196122.1 205 1.8e-13 PREDICTED: uncharacterized protein LOC658955 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3937 BP_3 10.00 12.48 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39374 BP_3 78.45 0.56 7047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39375 BP_3 870.26 3.55 12104 478249703 ENN70211.1 3709 0.0e+00 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 Q8R420 1191 2.5e-128 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00448//PF01225//PF13304//PF06414//PF00005//PF03193 SRP54-type protein, GTPase domain//Mur ligase family, catalytic domain//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006614//GO:0009058 SRP-dependent cotranslational protein targeting to membrane//biosynthetic process GO:0005524//GO:0005525//GO:0016301//GO:0016887//GO:0003924 ATP binding//GTP binding//kinase activity//ATPase activity//GTPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.39382 BP_3 2095.98 33.25 3330 642931643 XP_008196669.1 765 4.3e-78 PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum]>gi|642931645|ref|XP_972490.2| PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum] -- -- -- -- -- K04701 CISH cytokine inducible SH2-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04701 O14508 228 3.2e-17 Suppressor of cytokine signaling 2 OS=Homo sapiens GN=SOCS2 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.39383 BP_3 501.42 6.61 3947 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39384 BP_3 126.72 1.71 3872 642931522 XP_008196620.1 1351 5.5e-146 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 968 5.9e-103 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00288//PF00640 GHMP kinases N terminal domain//Phosphotyrosine interaction domain (PTB/PID) GO:0006012//GO:0046835 galactose metabolic process//carbohydrate phosphorylation GO:0004335//GO:0005515//GO:0005524 galactokinase activity//protein binding//ATP binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.39386 BP_3 86.46 1.00 4446 642931522 XP_008196620.1 1438 5.2e-156 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 1029 5.7e-110 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00640//PF00288 Phosphotyrosine interaction domain (PTB/PID)//GHMP kinases N terminal domain GO:0046835//GO:0006012 carbohydrate phosphorylation//galactose metabolic process GO:0005515//GO:0004335//GO:0005524 protein binding//galactokinase activity//ATP binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.39390 BP_3 142.30 1.95 3803 91091418 XP_971893.1 623 1.4e-61 PREDICTED: protein-associating with the carboxyl-terminal domain of ezrin [Tribolium castaneum]>gi|270000964|gb|EEZ97411.1| hypothetical protein TcasGA2_TC011240 [Tribolium castaneum] -- -- -- -- -- K17542 SCYL3 SCY1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17542 Q8IZE3 212 2.7e-15 Protein-associating with the carboxyl-terminal domain of ezrin OS=Homo sapiens GN=SCYL3 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39391 BP_3 442.60 5.56 4127 91091418 XP_971893.1 1787 1.6e-196 PREDICTED: protein-associating with the carboxyl-terminal domain of ezrin [Tribolium castaneum]>gi|270000964|gb|EEZ97411.1| hypothetical protein TcasGA2_TC011240 [Tribolium castaneum] -- -- -- -- -- K17542 SCYL3 SCY1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17542 Q9DBQ7 624 4.8e-63 Protein-associating with the carboxyl-terminal domain of ezrin OS=Mus musculus GN=Scyl3 PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1243 Protein kinase Cluster-8309.39392 BP_3 216.77 1.36 7957 642936743 XP_008198562.1 4787 0.0e+00 PREDICTED: neurexin-4 isoform X1 [Tribolium castaneum] 662206951 XM_008478733.1 135 3.2627e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 4092 0.0e+00 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF01106//PF00008//PF01648//PF03079 NifU-like domain//EGF-like domain//4'-phosphopantetheinyl transferase superfamily//ARD/ARD' family GO:0016226//GO:0015940//GO:0055114 iron-sulfur cluster assembly//pantothenate biosynthetic process//oxidation-reduction process GO:0010309//GO:0005515//GO:0008897//GO:0051536//GO:0005506//GO:0000287 acireductone dioxygenase [iron(II)-requiring] activity//protein binding//holo-[acyl-carrier-protein] synthase activity//iron-sulfur cluster binding//iron ion binding//magnesium ion binding -- -- -- -- Cluster-8309.39394 BP_3 62.00 11.84 544 270002182 EEZ98629.1 151 1.1e-07 hypothetical protein TcasGA2_TC001152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01623 Carlavirus putative nucleic acid binding protein GO:0006355 regulation of transcription, DNA-templated GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.39395 BP_3 2170.79 8.16 13108 91087317 XP_975584.1 18481 0.0e+00 PREDICTED: dynein heavy chain, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270010987|gb|EFA07435.1| dynein heavy chain [Tribolium castaneum] 795079236 XM_012021610.1 2194 0 PREDICTED: Vollenhovia emeryi dynein heavy chain, cytoplasmic (LOC105567063), transcript variant X7, mRNA K10413 DYNC1H dynein heavy chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10413 P37276 16654 0.0e+00 Dynein heavy chain, cytoplasmic OS=Drosophila melanogaster GN=Dhc64C PE=2 SV=2 PF07728//PF01695//PF12106//PF03028//PF00004//PF00437//PF02932//PF00005//PF01580//PF00910 AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Colicin C terminal ribonuclease domain//Dynein heavy chain and region D6 of dynein motor//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Neurotransmitter-gated ion-channel transmembrane region//ABC transporter//FtsK/SpoIIIE family//RNA helicase GO:0007018//GO:0006810//GO:0006200//GO:0007017//GO:0051252//GO:0006811 microtubule-based movement//transport//obsolete ATP catabolic process//microtubule-based process//regulation of RNA metabolic process//ion transport GO:0005524//GO:0004540//GO:0000166//GO:0016887//GO:0003723//GO:0003677//GO:0003777//GO:0003724 ATP binding//ribonuclease activity//nucleotide binding//ATPase activity//RNA binding//DNA binding//microtubule motor activity//RNA helicase activity GO:0030286//GO:0005874//GO:0016020 dynein complex//microtubule//membrane KOG3595 Dyneins, heavy chain Cluster-8309.39397 BP_3 280.82 6.98 2230 642919704 XP_008192030.1 2793 0.0e+00 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] 807042760 XM_012306425.1 116 3.30066e-51 PREDICTED: Ceratitis capitata serine/threonine-protein kinase par-1 (LOC101453227), transcript variant X3, mRNA K16311 SIK2 serine/threonine-protein kinase SIK2 http://www.genome.jp/dbget-bin/www_bget?ko:K16311 Q9H0K1 1262 2.7e-137 Serine/threonine-protein kinase SIK2 OS=Homo sapiens GN=SIK2 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0586 Serine/threonine protein kinase Cluster-8309.39398 BP_3 35.08 0.66 2854 642936148 XP_008198317.1 2296 1.1e-255 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Tribolium castaneum] 390176983 XM_003736203.1 122 1.95699e-54 Drosophila pseudoobscura pseudoobscura GA15183, transcript variant B (Dpse\GA15183), partial mRNA -- -- -- -- P34284 179 1.3e-11 Uncharacterized F-box/LRR-repeat protein C02F5.7 OS=Caenorhabditis elegans GN=C02F5.7 PE=3 SV=3 PF12937//PF00646//PF15966 F-box-like//F-box domain//F-box -- -- GO:0005515 protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.39399 BP_3 536.96 31.94 1102 642926175 XP_008194816.1 1560 9.1e-171 PREDICTED: vinculin isoform X6 [Tribolium castaneum] -- -- -- -- -- K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 1027 2.4e-110 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF01442//PF06009 Vinculin family//Apolipoprotein A1/A4/E domain//Laminin Domain II GO:0006869//GO:0042157//GO:0007155 lipid transport//lipoprotein metabolic process//cell adhesion GO:0051015//GO:0008289 actin filament binding//lipid binding GO:0005576 extracellular region KOG3681 Alpha-catenin Cluster-8309.39400 BP_3 3157.78 31.14 5179 642926169 XP_008194813.1 2776 4.1e-311 PREDICTED: vinculin isoform X3 [Tribolium castaneum] 665389295 NM_001297885.1 65 1.73377e-22 Drosophila melanogaster vinculin (Vinc), transcript variant C, mRNA K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 2024 2.8e-225 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01442//PF09141//PF04513//PF01044 Apolipoprotein A1/A4/E domain//Talin, middle domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Vinculin family GO:0006869//GO:0042157//GO:0007016//GO:0007155 lipid transport//lipoprotein metabolic process//cytoskeletal anchoring at plasma membrane//cell adhesion GO:0005198//GO:0008289//GO:0051015//GO:0005200 structural molecule activity//lipid binding//actin filament binding//structural constituent of cytoskeleton GO:0019031//GO:0005856//GO:0005925//GO:0019028//GO:0001726//GO:0005576 viral envelope//cytoskeleton//focal adhesion//viral capsid//ruffle//extracellular region KOG3681 Alpha-catenin Cluster-8309.39402 BP_3 185.89 3.21 3083 646682520 KDR02319.1 1568 3.0e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 3.59131e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.4e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF07714//PF00937//PF00069 Protein tyrosine kinase//Coronavirus nucleocapsid protein//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.39403 BP_3 32.72 0.65 2707 91085003 XP_973266.1 1283 3.0e-138 PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|642926204|ref|XP_008194828.1| PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|270009020|gb|EFA05468.1| hypothetical protein TcasGA2_TC015651 [Tribolium castaneum] 815925584 XM_012391990.1 107 4.04368e-46 PREDICTED: Bombus impatiens glycogen [starch] synthase (LOC100748309), transcript variant X8, mRNA K00693 GYS glycogen(starch) synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00693 Q9VFC8 1105 5.3e-119 Glycogen [starch] synthase OS=Drosophila melanogaster GN=GlyS PE=1 SV=2 PF05693 Glycogen synthase GO:0005982//GO:0005978//GO:0005985 starch metabolic process//glycogen biosynthetic process//sucrose metabolic process GO:0004373 glycogen (starch) synthase activity -- -- KOG3742 Glycogen synthase Cluster-8309.39405 BP_3 15.00 0.37 2221 270015831 EFA12279.1 1034 1.8e-109 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39406 BP_3 2253.15 24.78 4674 91086137 XP_968906.1 5668 0.0e+00 PREDICTED: sister chromatid cohesion protein PDS5 homolog B isoform X1 [Tribolium castaneum]>gi|270010223|gb|EFA06671.1| hypothetical protein TcasGA2_TC009599 [Tribolium castaneum] 170044604 XM_001849880.1 125 6.9229e-56 Culex quinquefasciatus androgen induced inhibitor of proliferation / pds5, mRNA K11267 PDS5 sister chromatid cohesion protein PDS5 http://www.genome.jp/dbget-bin/www_bget?ko:K11267 Q5F3U9 2271 5.7e-254 Sister chromatid cohesion protein PDS5 homolog B OS=Gallus gallus GN=PDS5B PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1525 Sister chromatid cohesion complex Cohesin, subunit PDS5 Cluster-8309.39407 BP_3 1435.42 21.44 3518 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 2.43528e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 8.1e-27 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF03526//PF00560//PF13855//PF13895 Colicin E1 (microcin) immunity protein//Leucine Rich Repeat//Leucine rich repeat//Immunoglobulin domain GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643//GO:0005515 toxic substance binding//protein binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.39409 BP_3 35.00 3.26 810 478255265 ENN75494.1 640 3.2e-64 hypothetical protein YQE_08043, partial [Dendroctonus ponderosae] -- -- -- -- -- K14157 AASS alpha-aminoadipic semialdehyde synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14157 A8E657 311 1.9e-27 Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Bos taurus GN=AASS PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase Cluster-8309.3941 BP_3 3.28 2.22 359 642929465 XP_974907.2 260 1.6e-20 PREDICTED: armadillo repeat-containing protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K486 151 3.0e-09 Armadillo repeat-containing protein 6 homolog OS=Drosophila melanogaster GN=CG5721 PE=1 SV=1 PF00701 Dihydrodipicolinate synthetase family GO:0008152 metabolic process GO:0016829 lyase activity -- -- -- -- Cluster-8309.39411 BP_3 597.76 5.85 5216 642934848 XP_008197836.1 1654 5.5e-181 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.46003e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA -- -- -- -- Q5JR59 239 2.7e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39413 BP_3 151.00 18.94 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39417 BP_3 17.59 0.48 2051 189237332 XP_973384.2 1523 3.3e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 6.7983e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 1.7e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.39418 BP_3 488.81 6.83 3742 189238300 XP_970863.2 4491 0.0e+00 PREDICTED: jmjC domain-containing histone demethylation protein 1 isoform X1 [Tribolium castaneum] 602630683 XM_007422193.1 38 1.27613e-07 PREDICTED: Python bivittatus PHD finger protein 8 (PHF8), transcript variant X4, mRNA K10276 FBXL10_11, KDM2 F-box and leucine-rich repeat protein 10/11 http://www.genome.jp/dbget-bin/www_bget?ko:K10276 Q9VHH9 1629 1.3e-179 JmjC domain-containing histone demethylation protein 1 OS=Drosophila melanogaster GN=Kdm2 PE=1 SV=2 PF16866//PF02008//PF00646//PF12937//PF13855 PHD-finger//CXXC zinc finger domain//F-box domain//F-box-like//Leucine rich repeat -- -- GO:0005515//GO:0003677//GO:0008270 protein binding//DNA binding//zinc ion binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.39419 BP_3 56.19 0.97 3083 642929609 XP_008195902.1 1940 2.2e-214 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] 642929608 XM_008197680.1 49 8.05373e-14 PREDICTED: Tribolium castaneum FAS-associated factor 1 (LOC664346), mRNA -- -- -- -- Q9UNN5 797 3.2e-83 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF09226//PF00240 Restriction endonuclease HincII//Ubiquitin family GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0005515//GO:0009036//GO:0003677 protein binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.39424 BP_3 889.15 6.23 7176 91081899 XP_976020.1 1589 2.6e-173 PREDICTED: cyclin-Y-like protein 1 [Tribolium castaneum]>gi|270007331|gb|EFA03779.1| hypothetical protein TcasGA2_TC013890 [Tribolium castaneum] 620962625 XM_007667839.1 113 4.99139e-49 PREDICTED: Ornithorhynchus anatinus cyclin Y (CCNY), mRNA K07881 RAB14 Ras-related protein Rab-14 http://www.genome.jp/dbget-bin/www_bget?ko:K07881 Q6NRF4 988 5.2e-105 Cyclin-Y-like protein 1-B OS=Xenopus laevis GN=ccnyl1-b PE=2 SV=1 PF08613//PF01926//PF08477//PF00735//PF00025//PF03193//PF00071//PF04670 Cyclin//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//ADP-ribosylation factor family//Protein of unknown function, DUF258//Ras family//Gtr1/RagA G protein conserved region GO:0000079//GO:0007264 regulation of cyclin-dependent protein serine/threonine kinase activity//small GTPase mediated signal transduction GO:0003924//GO:0019901//GO:0005525 GTPase activity//protein kinase binding//GTP binding -- -- KOG1675 Predicted cyclin Cluster-8309.39425 BP_3 11.63 1.24 744 91079354 XP_969967.1 486 2.1e-46 PREDICTED: eukaryotic translation initiation factor 3 subunit E [Tribolium castaneum]>gi|270003495|gb|EEZ99942.1| hypothetical protein TcasGA2_TC002738 [Tribolium castaneum] -- -- -- -- -- K03250 EIF3E, INT6 translation initiation factor 3 subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K03250 Q2F5R8 337 1.7e-30 Eukaryotic translation initiation factor 3 subunit E OS=Bombyx mori GN=eIF3-S6 PE=2 SV=1 -- -- GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm KOG2758 Translation initiation factor 3, subunit e (eIF-3e) Cluster-8309.39426 BP_3 288.00 20.74 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39430 BP_3 430.64 10.05 2357 189235871 XP_001811450.1 1667 7.7e-183 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39431 BP_3 2498.00 72.74 1947 195118306 XP_002003681.1 1022 3.9e-108 GI21581 [Drosophila mojavensis]>gi|193914256|gb|EDW13123.1| GI21581 [Drosophila mojavensis] -- -- -- -- -- K15620 GOLPH3, GPP34 golgi phosphoprotein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15620 Q9VQ93 1030 1.9e-110 Golgi phosphoprotein 3 homolog rotini OS=Drosophila melanogaster GN=rti PE=1 SV=1 PF05719 Golgi phosphoprotein 3 (GPP34) GO:0048193 Golgi vesicle transport GO:0070273 phosphatidylinositol-4-phosphate binding -- -- KOG3983 Golgi protein Cluster-8309.39432 BP_3 216.38 0.93 11448 341880419 EGT36354.1 163 9.3e-08 hypothetical protein CAEBREN_07651, partial [Caenorhabditis brenneri] -- -- -- -- -- -- -- -- -- Q914G7 343 5.2e-30 Uncharacterized protein 65 OS=Sulfolobus islandicus filamentous virus (isolate Iceland/Hveragerdi) GN=SIFV0065 PE=4 SV=1 PF03470//PF00096//PF13465//PF04434//PF05715//PF00136//PF03175 XS zinc finger domain//Zinc finger, C2H2 type//Zinc-finger double domain//SWIM zinc finger//Piccolo Zn-finger//DNA polymerase family B//DNA polymerase type B, organellar and viral GO:0006260//GO:0031047 DNA replication//gene silencing by RNA GO:0003677//GO:0003887//GO:0008408//GO:0000166//GO:0008270//GO:0046872 DNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//nucleotide binding//zinc ion binding//metal ion binding GO:0042575//GO:0045202 DNA polymerase complex//synapse -- -- Cluster-8309.39433 BP_3 3705.51 35.90 5267 282165786 NP_001164132.1 560 4.0e-54 cellular FABP-like protein isoform 3 [Tribolium castaneum]>gi|270009254|gb|EFA05702.1| cellular FABP-like protein [Tribolium castaneum] 797056877 HG313989.1 35 8.38043e-06 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 11 K08756 FABP7 fatty acid-binding protein 7, brain http://www.genome.jp/dbget-bin/www_bget?ko:K08756 A6YLM6 280 4.8e-23 Fatty acid-binding protein, adipocyte OS=Cervus elaphus GN=FABP4 PE=2 SV=1 PF02330 Mitochondrial glycoprotein GO:0006810 transport GO:0008289//GO:0005215 lipid binding//transporter activity GO:0005759 mitochondrial matrix KOG4015 Fatty acid-binding protein FABP Cluster-8309.39434 BP_3 68.83 1.81 2128 612015647 XP_007490773.1 466 1.3e-43 PREDICTED: zinc finger protein 347-like isoform X2 [Monodelphis domestica] 642923548 XM_008195332.1 36 9.32589e-07 PREDICTED: Tribolium castaneum zinc finger and SCAN domain-containing protein 2-like (LOC658870), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZN57 454 1.3e-43 Zinc finger protein 2 homolog OS=Homo sapiens GN=ZFP2 PE=1 SV=1 PF07975//PF13465//PF00096//PF07776//PF02892//PF13912 TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//BED zinc finger//C2H2-type zinc finger GO:0006281 DNA repair GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.39435 BP_3 2876.00 9.11 15515 270010181 EFA06629.1 16316 0.0e+00 hypothetical protein TcasGA2_TC009548 [Tribolium castaneum] -- -- -- -- -- K04550 LRP1, CD91 low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor) http://www.genome.jp/dbget-bin/www_bget?ko:K04550 P98157 8292 0.0e+00 Low-density lipoprotein receptor-related protein 1 OS=Gallus gallus GN=LRP1 PE=2 SV=1 PF09008//PF00008//PF00057//PF07645//PF06769//PF02022 Head binding//EGF-like domain//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//YoeB-like toxin of bacterial type II toxin-antitoxin system//Integrase Zinc binding domain GO:0006401//GO:0009405 RNA catabolic process//pathogenesis GO:0008270//GO:0004519//GO:0005509//GO:0005515 zinc ion binding//endonuclease activity//calcium ion binding//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.39437 BP_3 1130.09 25.37 2439 478263397 ENN81769.1 862 1.8e-89 hypothetical protein YQE_01862, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NDA2 232 8.2e-18 Hemicentin-2 OS=Homo sapiens GN=HMCN2 PE=2 SV=2 PF01108//PF15491//PF13895//PF00041//PF16656 Tissue factor//CST, telomere maintenance, complex subunit CTC1//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0000723//GO:0019497 riboflavin metabolic process//telomere maintenance//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.39439 BP_3 9.64 0.38 1501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39440 BP_3 1864.02 20.70 4632 642927044 XP_008195115.1 1565 1.0e-170 PREDICTED: LOW QUALITY PROTEIN: transmembrane protein 214-B [Tribolium castaneum] -- -- -- -- -- K03424 tatD TatD DNase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03424 Q148G4 835 1.9e-87 Putative deoxyribonuclease TATDN1 OS=Bos taurus GN=TATDN1 PE=2 SV=1 PF01026 TatD related DNase GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3020 TatD-related DNase Cluster-8309.39442 BP_3 1909.80 35.44 2889 91090890 XP_973414.1 3738 0.0e+00 PREDICTED: coatomer subunit gamma [Tribolium castaneum]>gi|270013230|gb|EFA09678.1| hypothetical protein TcasGA2_TC011806 [Tribolium castaneum] -- -- -- -- -- K17267 COPG coatomer protein complex, subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K17267 Q29AE5 2925 0.0e+00 Coatomer subunit gamma OS=Drosophila pseudoobscura pseudoobscura GN=gammaCop PE=3 SV=1 PF01602//PF02985//PF08752 Adaptin N terminal region//HEAT repeat//Coatomer gamma subunit appendage platform subdomain GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG1078 Vesicle coat complex COPI, gamma subunit Cluster-8309.39444 BP_3 365.34 5.54 3471 478253971 ENN74263.1 1931 2.8e-213 hypothetical protein YQE_09235, partial [Dendroctonus ponderosae] -- -- -- -- -- K08189 SLC16A13 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08189 Q7RTY0 334 1.7e-29 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF00473//PF05924//PF07690 Corticotropin-releasing factor family//SAMP Motif//Major Facilitator Superfamily GO:0007165//GO:0016055//GO:0055085 signal transduction//Wnt signaling pathway//transmembrane transport GO:0008013//GO:0005179 beta-catenin binding//hormone activity GO:0005576//GO:0016342//GO:0016021 extracellular region//catenin complex//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.39445 BP_3 46.96 0.55 4433 478253971 ENN74263.1 1931 3.5e-213 hypothetical protein YQE_09235, partial [Dendroctonus ponderosae] -- -- -- -- -- K08189 SLC16A13 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08189 Q7RTY0 334 2.2e-29 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF05924//PF07690 SAMP Motif//Major Facilitator Superfamily GO:0016055//GO:0055085 Wnt signaling pathway//transmembrane transport GO:0008013 beta-catenin binding GO:0016021//GO:0016342 integral component of membrane//catenin complex KOG2504 Monocarboxylate transporter Cluster-8309.39448 BP_3 279.55 7.90 1998 91087311 XP_975575.1 1011 7.6e-107 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K14291 PHAX phosphorylated adapter RNA export protein http://www.genome.jp/dbget-bin/www_bget?ko:K14291 Q5ZLY0 263 1.7e-21 Phosphorylated adapter RNA export protein OS=Gallus gallus GN=PHAX PE=2 SV=1 PF09415//PF01287//PF02269 CENP-S associating Centromere protein X//Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//Transcription initiation factor IID, 18kD subunit GO:0006281//GO:0006366//GO:0006448//GO:0006452//GO:0051382//GO:0045901//GO:0045905 DNA repair//transcription from RNA polymerase II promoter//regulation of translational elongation//translational frameshifting//kinetochore assembly//positive regulation of translational elongation//positive regulation of translational termination GO:0043022//GO:0003723//GO:0003746 ribosome binding//RNA binding//translation elongation factor activity GO:0005840 ribosome KOG3948 Mediator of U snRNA nuclear export PHAX Cluster-8309.39449 BP_3 1127.02 41.49 1601 478254491 ENN74739.1 327 1.3e-27 hypothetical protein YQE_08677, partial [Dendroctonus ponderosae] -- -- -- -- -- K15623 SS18, SSXT, SYT protein SSXT http://www.genome.jp/dbget-bin/www_bget?ko:K15623 O75177 205 7.2e-15 Calcium-responsive transactivator OS=Homo sapiens GN=SS18L1 PE=1 SV=2 PF16035 Chalcone isomerase like -- -- GO:0016872 intramolecular lyase activity -- -- KOG3227 Calcium-responsive transcription coactivator Cluster-8309.39453 BP_3 26885.16 2221.71 875 546676497 ERL87495.1 1085 8.7e-116 hypothetical protein D910_04887, partial [Dendroctonus ponderosae] 164683615 EU373305.1 547 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 1081 1.0e-116 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 PF00091//PF04816 Tubulin/FtsZ family, GTPase domain//tRNA (adenine(22)-N(1))-methyltransferase GO:0008033//GO:0009451 tRNA processing//RNA modification GO:0016429//GO:0003924 tRNA (adenine-N1-)-methyltransferase activity//GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.39454 BP_3 96.69 2.40 2237 91084421 XP_968215.1 1313 8.2e-142 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35502 844 8.1e-89 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06467//PF07425//PF00326//PF07859 MYM-type Zinc finger with FCS sequence motif//Pardaxin//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787//GO:0008270 serine-type peptidase activity//hydrolase activity//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.39456 BP_3 1044.04 5.95 8745 642927636 XP_008195344.1 4923 0.0e+00 PREDICTED: zinc finger FYVE domain-containing protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGP1 1082 8.0e-116 Zinc finger FYVE domain-containing protein 26 homolog OS=Drosophila melanogaster GN=CG5270 PE=1 SV=3 PF02419//PF01363//PF04805 PsbL protein//FYVE zinc finger//E10-like protein conserved region GO:0055114//GO:0015979 oxidation-reduction process//photosynthesis GO:0046872//GO:0016972 metal ion binding//thiol oxidase activity GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane KOG1811 Predicted Zn2+-binding protein, contains FYVE domain Cluster-8309.39462 BP_3 111.41 0.57 9634 642930696 XP_008199991.1 1575 1.5e-171 PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930698|ref|XP_008199992.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930700|ref|XP_008199993.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|270012671|gb|EFA09119.1| hypothetical protein TcasGA2_TC015979 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11883 1236 1.2e-133 Aldehyde dehydrogenase, dimeric NADP-preferring OS=Rattus norvegicus GN=Aldh3a1 PE=1 SV=3 PF00106//PF08656//PF01370//PF02558//PF07690//PF00171 short chain dehydrogenase//DASH complex subunit Dad3//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA//Major Facilitator Superfamily//Aldehyde dehydrogenase family GO:0006547//GO:0006081//GO:0008152//GO:0008608//GO:0006094//GO:0006558//GO:0055114//GO:0006096//GO:0015940//GO:0055085//GO:0006570 histidine metabolic process//cellular aldehyde metabolic process//metabolic process//attachment of spindle microtubules to kinetochore//gluconeogenesis//L-phenylalanine metabolic process//oxidation-reduction process//glycolytic process//pantothenate biosynthetic process//transmembrane transport//tyrosine metabolic process GO:0008677//GO:0004030//GO:0003824//GO:0016491//GO:0050662 2-dehydropantoate 2-reductase activity//aldehyde dehydrogenase [NAD(P)+] activity//catalytic activity//oxidoreductase activity//coenzyme binding GO:0072686//GO:0042729//GO:0016021 mitotic spindle//DASH complex//integral component of membrane KOG2456 Aldehyde dehydrogenase Cluster-8309.39463 BP_3 22.52 0.46 2631 91087137 XP_975265.1 2113 1.6e-234 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein [Tribolium castaneum]>gi|270009591|gb|EFA06039.1| hypothetical protein TcasGA2_TC008869 [Tribolium castaneum] -- -- -- -- -- K05289 GAA1 glycosylphosphatidylinositol transamidase http://www.genome.jp/dbget-bin/www_bget?ko:K05289 O43292 803 5.4e-84 Glycosylphosphatidylinositol anchor attachment 1 protein OS=Homo sapiens GN=GPAA1 PE=1 SV=3 PF04114 Gaa1-like, GPI transamidase component -- -- -- -- GO:0042765//GO:0016021 GPI-anchor transamidase complex//integral component of membrane KOG3566 Glycosylphosphatidylinositol anchor attachment protein GAA1 Cluster-8309.39464 BP_3 193.00 30.67 595 270011248 EFA07696.1 152 9.1e-08 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39465 BP_3 51.95 0.34 7751 189235813 XP_971989.2 2629 7.1e-294 PREDICTED: probable cytosolic oligopeptidase A [Tribolium castaneum] 689005257 LL516414.1 39 7.38308e-08 Onchocerca ochengi genome assembly O_ochengi_Ngaoundere ,scaffold OOCN_contig0000027 K01414 prlC oligopeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01414 Q94AM1 924 1.5e-97 Organellar oligopeptidase A, chloroplastic/mitochondrial OS=Arabidopsis thaliana GN=OOP PE=1 SV=1 PF05366//PF07541//PF00515//PF13414//PF01432//PF02543//PF11744 Sarcolipin//Eukaryotic translation initiation factor 2 alpha subunit//Tetratricopeptide repeat//TPR repeat//Peptidase family M3//Carbamoyltransferase N-terminus//Aluminium activated malate transporter GO:0015743//GO:0006446//GO:0009058//GO:0006508 malate transport//regulation of translational initiation//biosynthetic process//proteolysis GO:0005515//GO:0003824//GO:0004222//GO:0003723//GO:0003743//GO:0030234 protein binding//catalytic activity//metalloendopeptidase activity//RNA binding//translation initiation factor activity//enzyme regulator activity GO:0005850//GO:0005840//GO:0016020 eukaryotic translation initiation factor 2 complex//ribosome//membrane KOG2708 Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold) Cluster-8309.39466 BP_3 338.48 7.12 2583 91087137 XP_975265.1 2140 1.2e-237 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein [Tribolium castaneum]>gi|270009591|gb|EFA06039.1| hypothetical protein TcasGA2_TC008869 [Tribolium castaneum] -- -- -- -- -- K05289 GAA1 glycosylphosphatidylinositol transamidase http://www.genome.jp/dbget-bin/www_bget?ko:K05289 O43292 830 3.9e-87 Glycosylphosphatidylinositol anchor attachment 1 protein OS=Homo sapiens GN=GPAA1 PE=1 SV=3 PF02163//PF04114 Peptidase family M50//Gaa1-like, GPI transamidase component GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity GO:0016021//GO:0042765 integral component of membrane//GPI-anchor transamidase complex KOG3566 Glycosylphosphatidylinositol anchor attachment protein GAA1 Cluster-8309.39467 BP_3 426.77 14.50 1710 91087553 XP_970739.1 1460 5.6e-159 PREDICTED: protein farnesyltransferase subunit beta [Tribolium castaneum]>gi|270010683|gb|EFA07131.1| hypothetical protein TcasGA2_TC010122 [Tribolium castaneum] 56758975 AY815896.1 42 3.4479e-10 Schistosoma japonicum SJCHGC09483 protein mRNA, complete cds K05954 FNTB protein farnesyltransferase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K05954 P49356 1044 4.0e-112 Protein farnesyltransferase subunit beta OS=Homo sapiens GN=FNTB PE=1 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat GO:0018343//GO:0042127 protein farnesylation//regulation of cell proliferation GO:0003824 catalytic activity GO:0005965 protein farnesyltransferase complex KOG0365 Beta subunit of farnesyltransferase Cluster-8309.39468 BP_3 42.33 0.88 2621 91086165 XP_970259.1 2708 1.7e-303 PREDICTED: ATP-dependent zinc metalloprotease YME1 homolog [Tribolium castaneum]>gi|270009883|gb|EFA06331.1| hypothetical protein TcasGA2_TC009202 [Tribolium castaneum] 759074133 XM_011348443.1 98 3.94403e-41 PREDICTED: Cerapachys biroi ATP-dependent zinc metalloprotease YME1 homolog (LOC105284713), transcript variant X3, mRNA K08955 YME1 ATP-dependent metalloprotease http://www.genome.jp/dbget-bin/www_bget?ko:K08955 P54813 1417 3.4e-155 ATP-dependent zinc metalloprotease YME1 homolog OS=Caenorhabditis elegans GN=ymel-1 PE=3 SV=2 PF01695//PF07728//PF05496//PF00158//PF06068//PF00004//PF01434//PF07724//PF10415//PF02562//PF02367//PF06414 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Peptidase family M41//AAA domain (Cdc48 subfamily)//Fumarase C C-terminus//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin GO:0030163//GO:0002949//GO:0006310//GO:0006508//GO:0006281//GO:0006355//GO:0006099 protein catabolic process//tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis//DNA repair//regulation of transcription, DNA-templated//tricarboxylic acid cycle GO:0003678//GO:0009378//GO:0017111//GO:0008134//GO:0005524//GO:0004222//GO:0016829//GO:0016301//GO:0016887 DNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//transcription factor binding//ATP binding//metalloendopeptidase activity//lyase activity//kinase activity//ATPase activity GO:0005667//GO:0005657//GO:0016020//GO:0009379 transcription factor complex//replication fork//membrane//Holliday junction helicase complex KOG0734 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.39469 BP_3 218.72 7.51 1695 642928935 XP_008195623.1 1417 5.4e-154 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9VCX1 836 5.2e-88 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF02196//PF00788 Raf-like Ras-binding domain//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- -- -- Cluster-8309.39470 BP_3 544.99 3.28 8291 642913946 XP_008201225.1 10435 0.0e+00 PREDICTED: leucine-rich repeat serine/threonine-protein kinase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TZM3 2906 0.0e+00 Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6 PF13606//PF07714//PF08477//PF00069//PF00025//PF13855//PF07645//PF00023//PF00071 Ankyrin repeat//Protein tyrosine kinase//Ras of Complex, Roc, domain of DAPkinase//Protein kinase domain//ADP-ribosylation factor family//Leucine rich repeat//Calcium-binding EGF domain//Ankyrin repeat//Ras family GO:0007264//GO:0006468 small GTPase mediated signal transduction//protein phosphorylation GO:0005515//GO:0004672//GO:0005525//GO:0005524//GO:0005509 protein binding//protein kinase activity//GTP binding//ATP binding//calcium ion binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.39471 BP_3 201.47 4.00 2722 642917631 XP_008193400.1 1846 1.6e-203 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 967 5.4e-103 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF01728//PF01585 FtsJ-like methyltransferase//G-patch domain GO:0032259 methylation GO:0008168//GO:0003676 methyltransferase activity//nucleic acid binding -- -- KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.39473 BP_3 29.64 0.35 4378 642913762 XP_008201150.1 4245 0.0e+00 PREDICTED: neuropathy target esterase sws isoform X2 [Tribolium castaneum] -- -- -- -- -- K14676 NTE, NRE lysophospholipid hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14676 B4IL64 2865 0.0e+00 Neuropathy target esterase sws OS=Drosophila sechellia GN=sws PE=3 SV=1 PF12387//PF01734 Pestivirus NS2 peptidase//Patatin-like phospholipase GO:0006629//GO:0006144//GO:0006508 lipid metabolic process//purine nucleobase metabolic process//proteolysis GO:0070008//GO:0003968//GO:0004252//GO:0016817//GO:0017111//GO:0004197 serine-type exopeptidase activity//RNA-directed RNA polymerase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//nucleoside-triphosphatase activity//cysteine-type endopeptidase activity GO:0031379 RNA-directed RNA polymerase complex KOG2968 Predicted esterase of the alpha-beta hydrolase superfamily (Neuropathy target esterase), contains cAMP-binding domains Cluster-8309.39475 BP_3 2398.07 15.09 7949 642927516 XP_970801.3 2072 2.8e-229 PREDICTED: RNA-binding protein fusilli isoform X2 [Tribolium castaneum] 170047638 XM_001851269.1 219 6.57348e-108 Culex quinquefasciatus conserved hypothetical protein, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 1080 1.2e-115 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 PF00666//PF12763//PF12356//PF00076 Cathelicidin//Cytoskeletal-regulatory complex EF hand//Protein of unknown function (DUF3643)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006915//GO:0032465//GO:0016567//GO:0006952 apoptotic process//regulation of cytokinesis//protein ubiquitination//defense response GO:0003676//GO:0005515//GO:0004842 nucleic acid binding//protein binding//ubiquitin-protein transferase activity GO:0005576 extracellular region KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.39477 BP_3 684.55 10.38 3469 642927514 XP_008195300.1 2879 0.0e+00 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] 170047638 XM_001851269.1 219 2.85311e-108 Culex quinquefasciatus conserved hypothetical protein, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 1317 1.8e-143 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.39478 BP_3 86.35 0.50 8685 270009943 EFA06391.1 192 3.1e-11 hypothetical protein TcasGA2_TC009269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009//PF00570//PF12763//PF12356//PF06061 Telomerase ribonucleoprotein complex - RNA binding domain//HRDC domain//Cytoskeletal-regulatory complex EF hand//Protein of unknown function (DUF3643)//Baculoviridae ME53 GO:0032465//GO:0006278//GO:0016567//GO:0006915 regulation of cytokinesis//RNA-dependent DNA replication//protein ubiquitination//apoptotic process GO:0003677//GO:0003964//GO:0004842//GO:0005515//GO:0008270//GO:0003676 DNA binding//RNA-directed DNA polymerase activity//ubiquitin-protein transferase activity//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.39479 BP_3 3.64 0.80 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39480 BP_3 689.79 3.11 10995 270008334 EFA04782.1 2089 4.2e-231 hypothetical protein TcasGA2_TC030779 [Tribolium castaneum] -- -- -- -- -- K10630 RBCK1, HOIL1 RanBP-type and C3HC4-type zinc finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10630 E6ZIJ1 896 3.7e-94 RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Dicentrarchus labrax GN=rbck1 PE=3 SV=1 PF09174//PF13639//PF14634//PF00641//PF00240//PF00097 Maf1 regulator//Ring finger domain//zinc-RING finger domain//Zn-finger in Ran binding protein and others//Ubiquitin family//Zinc finger, C3HC4 type (RING finger) GO:0016480 negative regulation of transcription from RNA polymerase III promoter GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.39483 BP_3 689.00 11.63 3146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39484 BP_3 175.78 1.11 7898 270016510 EFA12956.1 3014 0.0e+00 pumilio [Tribolium castaneum] 642939433 XM_008202167.1 706 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 2.0e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806 CPL (NUC119) domain//Pumilio-family RNA binding repeat -- -- GO:0003723 RNA binding -- -- KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.39485 BP_3 4920.92 92.86 2846 91093363 XP_969584.1 1352 3.1e-146 PREDICTED: proliferation-associated protein 2G4 [Tribolium castaneum]>gi|270015297|gb|EFA11745.1| hypothetical protein TcasGA2_TC004235 [Tribolium castaneum] 332374437 BT127398.1 224 3.88032e-111 Dendroctonus ponderosae clone DPO1122_M15 unknown mRNA -- -- -- -- Q6AYD3 948 9.0e-101 Proliferation-associated protein 2G4 OS=Rattus norvegicus GN=Pa2g4 PE=1 SV=1 PF01295 Adenylate cyclase, class-I GO:0006144//GO:0006171//GO:0009987 purine nucleobase metabolic process//cAMP biosynthetic process//cellular process GO:0004016 adenylate cyclase activity -- -- KOG2776 Metallopeptidase Cluster-8309.39486 BP_3 759.53 3.89 9700 642912783 XP_008201250.1 854 5.9e-88 PREDICTED: held out wings isoform X1 [Tribolium castaneum] 645014013 XM_008207131.1 156 8.43583e-73 PREDICTED: Nasonia vitripennis protein held out wings (LOC100120734), mRNA K14945 QKI protein quaking http://www.genome.jp/dbget-bin/www_bget?ko:K14945 O01367 770 1.3e-79 Protein held out wings OS=Drosophila melanogaster GN=how PE=1 SV=1 PF00013//PF13014//PF13103//PF13762 KH domain//KH domain//TonB C terminal//Mitochondrial splicing apparatus component GO:0000372//GO:0006810 Group I intron splicing//transport GO:0003723 RNA binding GO:0030529 intracellular ribonucleoprotein complex KOG1588 RNA-binding protein Sam68 and related KH domain proteins Cluster-8309.39487 BP_3 6767.38 53.60 6377 270016366 EFA12812.1 585 6.1e-57 hypothetical protein TcasGA2_TC001877 [Tribolium castaneum] 642933104 XM_008199038.1 222 1.13216e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA K13199 SERBP1 plasminogen activator inhibitor 1 RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13199 Q9CY58 193 7.1e-13 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0000166//GO:0004814 ATP binding//nucleotide binding//arginine-tRNA ligase activity GO:0005737 cytoplasm KOG2945 Predicted RNA-binding protein Cluster-8309.39488 BP_3 128.52 1.08 6048 642923353 XP_008193715.1 2686 1.4e-300 PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q80VJ4 958 1.3e-101 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Rattus norvegicus GN=Gpcpd1 PE=2 SV=1 PF00686//PF03009 Starch binding domain//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:2001070//GO:0008081 starch binding//phosphoric diester hydrolase activity -- -- KOG2421 Predicted starch-binding protein Cluster-8309.39489 BP_3 992.39 11.04 4624 642916846 XP_008199527.1 814 1.2e-83 PREDICTED: failed axon connections isoform X2 [Tribolium castaneum]>gi|270003072|gb|EEZ99519.1| hypothetical protein TcasGA2_TC000100 [Tribolium castaneum] 642916844 XM_963303.3 271 4.72746e-137 PREDICTED: Tribolium castaneum failed axon connections (LOC656797), transcript variant X1, mRNA -- -- -- -- Q95RI5 693 5.4e-71 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF02535//PF06459//PF06213//PF16834//PF02724//PF05132//PF13417 ZIP Zinc transporter//Ryanodine Receptor TM 4-6//Cobalamin biosynthesis protein CobT//Shu complex component Csm2, DNA-binding//CDC45-like protein//RNA polymerase III RPC4//Glutathione S-transferase, N-terminal domain GO:0000725//GO:0006206//GO:0006144//GO:0006351//GO:0030001//GO:0006383//GO:0009236//GO:0006874//GO:0006270//GO:0055085//GO:0006816 recombinational repair//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//metal ion transport//transcription from RNA polymerase III promoter//cobalamin biosynthetic process//cellular calcium ion homeostasis//DNA replication initiation//transmembrane transport//calcium ion transport GO:0046873//GO:0005219//GO:0005515//GO:0003677//GO:0003899 metal ion transmembrane transporter activity//ryanodine-sensitive calcium-release channel activity//protein binding//DNA binding//DNA-directed RNA polymerase activity GO:0097196//GO:0016020//GO:0005634//GO:0005666//GO:0005730//GO:0005622//GO:0016021 Shu complex//membrane//nucleus//DNA-directed RNA polymerase III complex//nucleolus//intracellular//integral component of membrane -- -- Cluster-8309.39495 BP_3 4010.98 45.57 4534 189238710 XP_969341.2 3029 0.0e+00 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 642927019 XM_964248.3 155 1.41276e-72 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q86VQ3 216 1.1e-15 Thioredoxin domain-containing protein 2 OS=Homo sapiens GN=TXNDC2 PE=2 SV=4 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.39496 BP_3 481.92 3.91 6230 642928815 XP_967995.2 1339 2.2e-144 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 167 7.2e-10 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.39498 BP_3 73.68 0.93 4130 642922280 XP_008193091.1 2505 9.1e-280 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.9e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- KOG3731 Sulfatases Cluster-8309.39499 BP_3 41.93 0.75 2974 288869514 NP_001165864.1 1669 5.7e-183 extended synaptotagmin-like protein 2a [Tribolium castaneum]>gi|642923659|ref|XP_008193831.1| PREDICTED: extended synaptotagmin-like protein 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5FWL4 697 1.2e-71 Extended synaptotagmin-2-A OS=Xenopus laevis GN=esyt2-a PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.39500 BP_3 34.02 0.59 3053 270007722 EFA04170.1 2265 4.5e-252 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 801 1.1e-83 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.39505 BP_3 783.53 17.66 2430 478263612 ENN81918.1 2067 3.3e-229 hypothetical protein YQE_01630, partial [Dendroctonus ponderosae] 768432559 XM_011559308.1 120 2.15221e-53 PREDICTED: Plutella xylostella succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (LOC105388405), mRNA K01027 OXCT 3-oxoacid CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K01027 Q9D0K2 1654 1.0e-182 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Mus musculus GN=Oxct1 PE=1 SV=1 PF00816//PF01144 H-NS histone family//Coenzyme A transferase GO:0008152//GO:0006355 metabolic process//regulation of transcription, DNA-templated GO:0003677//GO:0008410 DNA binding//CoA-transferase activity GO:0005622 intracellular KOG3822 Succinyl-CoA:alpha-ketoacid-CoA transferase Cluster-8309.39508 BP_3 8.97 0.32 1663 546677127 ERL88024.1 1348 5.3e-146 hypothetical protein D910_05413 [Dendroctonus ponderosae] -- -- -- -- -- K12261 HACL1 2-hydroxyacyl-CoA lyase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12261 Q8CHM7 929 8.4e-99 2-hydroxyacyl-CoA lyase 1 OS=Rattus norvegicus GN=Hacl1 PE=1 SV=1 PF02775//PF00205 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Thiamine pyrophosphate enzyme, central domain -- -- GO:0000287//GO:0030976//GO:0003824 magnesium ion binding//thiamine pyrophosphate binding//catalytic activity -- -- KOG1185 Thiamine pyrophosphate-requiring enzyme Cluster-8309.39509 BP_3 807.46 3.48 11481 270014673 EFA11121.1 14721 0.0e+00 hypothetical protein TcasGA2_TC004721 [Tribolium castaneum] 642911110 XM_008202361.1 2855 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 6850 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF16794//PF15170//PF01891//PF01108//PF16656//PF01300//PF13895//PF00041 Fibronectin-III type domain//Calcium/calmodulin-dependent protein kinase II inhibitor//Cobalt uptake substrate-specific transmembrane region//Tissue factor//Purple acid Phosphatase, N-terminal domain//Telomere recombination//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0045859//GO:0006771//GO:0000041 hexachlorocyclohexane metabolic process//regulation of protein kinase activity//riboflavin metabolic process//transition metal ion transport GO:0005515//GO:0004860//GO:0046872//GO:0003725//GO:0003993 protein binding//protein kinase inhibitor activity//metal ion binding//double-stranded RNA binding//acid phosphatase activity GO:0016021 integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.39510 BP_3 349.50 2.35 7463 642935862 XP_008198202.1 2012 2.4e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 9.12923e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 3.9e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF00638//PF02064//PF13181//PF00400//PF13371//PF13374//PF00515//PF13414//PF13176 RanBP1 domain//MAS20 protein import receptor//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006605//GO:0006886//GO:0046907 protein targeting//intracellular protein transport//intracellular transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.39511 BP_3 1809.26 82.64 1347 642915333 XP_008190576.1 291 1.6e-23 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K05465 ANGPT1 angiopoietin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05465 O18920 240 5.3e-19 Angiopoietin-1 OS=Bos taurus GN=ANGPT1 PE=2 SV=3 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.39512 BP_3 526.13 2.03 12781 642918534 XP_008191512.1 3762 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.63484e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1239 7.3e-134 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02383//PF05461//PF13895 SacI homology domain//Apolipoprotein L//Immunoglobulin domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0008289//GO:0042578 protein binding//lipid binding//phosphoric ester hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.39513 BP_3 879.25 3.25 13322 478257788 ENN77931.1 3797 0.0e+00 hypothetical protein YQE_05608, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 435 1.3e-40 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF10034//PF00023//PF10510//PF13606 Q-cell neuroblast polarisation//Ankyrin repeat//Phosphatidylinositol-glycan biosynthesis class S protein//Ankyrin repeat GO:0016255 attachment of GPI anchor to protein GO:0005515 protein binding GO:0016021//GO:0042765 integral component of membrane//GPI-anchor transamidase complex -- -- Cluster-8309.39514 BP_3 690.26 16.71 2283 91077394 XP_975293.1 2103 2.1e-233 PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|642913902|ref|XP_008201207.1| PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|270001645|gb|EEZ98092.1| hypothetical protein TcasGA2_TC000505 [Tribolium castaneum] -- -- -- -- -- K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 P52170 1420 1.3e-155 Importin subunit alpha-5 OS=Xenopus laevis GN=kpna1 PE=1 SV=2 PF02985//PF10508//PF01749//PF00514//PF11698//PF01602 HEAT repeat//Proteasome non-ATPase 26S subunit//Importin beta binding domain//Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region GO:0016192//GO:0006886//GO:0015991//GO:0015031//GO:0006606//GO:0043248 vesicle-mediated transport//intracellular protein transport//ATP hydrolysis coupled proton transport//protein transport//protein import into nucleus//proteasome assembly GO:0005515//GO:0016820//GO:0008565 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein transporter activity GO:0000221//GO:0005634//GO:0030117//GO:0005737 vacuolar proton-transporting V-type ATPase, V1 domain//nucleus//membrane coat//cytoplasm KOG0166 Karyopherin (importin) alpha Cluster-8309.39515 BP_3 1157.90 21.91 2839 91087269 XP_975538.1 1849 7.3e-204 PREDICTED: acyl-CoA synthetase family member 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18660 ACSF3 malonyl-CoA/methylmalonyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K18660 Q3URE1 1113 6.6e-120 Acyl-CoA synthetase family member 3, mitochondrial OS=Mus musculus GN=Acsf3 PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.39516 BP_3 85.19 1.16 3825 189239444 XP_001815329.1 163 3.1e-08 PREDICTED: E3 ubiquitin-protein ligase sina [Tribolium castaneum]>gi|270009612|gb|EFA06060.1| hypothetical protein TcasGA2_TC008895 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145//PF02176 Seven in absentia protein family//TRAF-type zinc finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.39518 BP_3 313.00 22.47 963 270004992 EFA01440.1 391 2.9e-35 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39519 BP_3 2170.30 27.33 4119 270007410 EFA03858.1 1820 2.4e-200 hypothetical protein TcasGA2_TC013974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39522 BP_3 12.51 0.33 2096 91076450 XP_971668.1 1244 7.7e-134 PREDICTED: eukaryotic peptide chain release factor subunit 1 [Tribolium castaneum]>gi|270002429|gb|EEZ98876.1| hypothetical protein TcasGA2_TC004489 [Tribolium castaneum] 642912506 XM_966575.3 337 4.34531e-174 PREDICTED: Tribolium castaneum eukaryotic peptide chain release factor subunit 1 (LOC660337), mRNA K03265 ETF1, ERF1 peptide chain release factor subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03265 Q9VPH7 1238 1.6e-134 Eukaryotic peptide chain release factor subunit 1 OS=Drosophila melanogaster GN=eRF1 PE=1 SV=2 -- -- GO:0006449//GO:0006415 regulation of translational termination//translational termination GO:0016149 translation release factor activity, codon specific GO:0018444//GO:0005737//GO:0005840 translation release factor complex//cytoplasm//ribosome KOG0688 Peptide chain release factor 1 (eRF1) Cluster-8309.39525 BP_3 660.68 22.66 1697 642939897 XP_008200232.1 157 6.9e-08 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39529 BP_3 2354.21 25.10 4813 642939895 XP_008200229.1 2108 1.1e-233 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] 657546453 XM_008280188.1 50 3.51061e-14 PREDICTED: Stegastes partitus protein tyrosine phosphatase, non-receptor type 6 (ptpn6), mRNA K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q90687 1394 2.9e-152 Tyrosine-protein phosphatase non-receptor type 11 OS=Gallus gallus GN=PTPN11 PE=2 SV=1 PF00102//PF00782//PF03832 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//WSK motif GO:0006570//GO:0006470//GO:0007165//GO:0006605 tyrosine metabolic process//protein dephosphorylation//signal transduction//protein targeting GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes Cluster-8309.39533 BP_3 51.84 1.06 2643 546681897 ERL91906.1 674 1.2e-67 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 347 4.1e-31 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39535 BP_3 106.70 1.18 4646 270004796 EFA01244.1 927 9.7e-97 sprouty-related protein with EVH-1 domain [Tribolium castaneum] 237823395 AB443867.1 36 2.05346e-06 Culex quinquefasciatus CqGSTd1 gene for glutathione transferase, complete cds, alternative splicing K04703 SPRED sprouty-related, EVH1 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04703 P46430 446 2.4e-42 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF05210//PF13409//PF13417//PF02798 Sprouty protein (Spry)//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.39536 BP_3 1690.12 25.72 3459 642925269 XP_008194486.1 2058 5.2e-228 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 1133 3.9e-122 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF01542//PF03600//PF00939 Hepatitis C virus core protein//Citrate transporter//Sodium:sulfate symporter transmembrane region GO:0006810//GO:0055085//GO:0006814 transport//transmembrane transport//sodium ion transport GO:0005198//GO:0005215 structural molecule activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.39537 BP_3 6865.44 116.63 3129 91087875 XP_969719.1 1282 4.5e-138 PREDICTED: 14-3-3 protein epsilon [Tribolium castaneum]>gi|270012013|gb|EFA08461.1| hypothetical protein TcasGA2_TC006109 [Tribolium castaneum] 346713643 AK386529.1 334 3.03304e-172 Bombyx mori mRNA, clone: fprW12H08 K06630 YWHAE 14-3-3 protein epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K06630 P92177 1166 5.2e-126 14-3-3 protein epsilon OS=Drosophila melanogaster GN=14-3-3epsilon PE=1 SV=2 PF13181//PF08038//PF00060 Tetratricopeptide repeat//TOM7 family//Ligand-gated ion channel GO:0007165//GO:0030150//GO:0007268//GO:0006811 signal transduction//protein import into mitochondrial matrix//synaptic transmission//ion transport GO:0019904//GO:0005515//GO:0004970 protein domain specific binding//protein binding//ionotropic glutamate receptor activity GO:0016020//GO:0005742 membrane//mitochondrial outer membrane translocase complex KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.39538 BP_3 2092.96 89.09 1424 818214314 AKG26772.1 1091 2.9e-116 peroxiredoxin 1 [Dastarcus helophoroides] 665815945 XM_008558436.1 97 7.61922e-41 PREDICTED: Microplitis demolitor peroxiredoxin-2 (LOC103577681), partial mRNA K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9BGI2 934 1.9e-99 Peroxiredoxin-4 OS=Bos taurus GN=PRDX4 PE=2 SV=1 PF10417//PF00578//PF08534 C-terminal domain of 1-Cys peroxiredoxin//AhpC/TSA family//Redoxin GO:0055114 oxidation-reduction process GO:0051920//GO:0016209//GO:0016491 peroxiredoxin activity//antioxidant activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.39539 BP_3 228.49 5.02 2487 820805560 AKG92771.1 1543 1.9e-168 daugherless [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P51514 146 7.8e-08 Transcription factor 12 OS=Rattus norvegicus GN=Tcf12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39541 BP_3 556.99 2.47 11142 642911559 XP_970343.3 4078 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 280 1.13583e-141 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 3196 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF08074//PF03808//PF00640//PF04689//PF00176//PF01874 CHDCT2 (NUC038) domain//Glycosyl transferase WecB/TagA/CpsF family//Phosphotyrosine interaction domain (PTB/PID)//DNA binding protein S1FA//SNF2 family N-terminal domain//ATP:dephospho-CoA triphosphoribosyl transferase GO:0016310//GO:0009058//GO:0006355 phosphorylation//biosynthetic process//regulation of transcription, DNA-templated GO:0046917//GO:0005515//GO:0003677//GO:0005524//GO:0016818//GO:0008270 triphosphoribosyl-dephospho-CoA synthase activity//protein binding//DNA binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.39542 BP_3 39.75 0.39 5242 817052050 XP_012254225.1 1951 2.0e-215 PREDICTED: cGMP-dependent 3',5'-cyclic phosphodiesterase-like isoform X2 [Athalia rosae] -- -- -- -- -- K18283 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K18283 P14099 1564 6.2e-172 cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Bos taurus GN=PDE2A PE=1 SV=2 PF00494//PF05699//PF11590//PF13185//PF00233//PF01590//PF13492 Squalene/phytoene synthase//hAT family C-terminal dimerisation region//DNA polymerase catalytic subunit Pol//GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain GO:0007165//GO:0006144//GO:0006260//GO:0009058//GO:0051252 signal transduction//purine nucleobase metabolic process//DNA replication//biosynthetic process//regulation of RNA metabolic process GO:0004114//GO:0016740//GO:0046983//GO:0005515//GO:0003887//GO:0004523 3',5'-cyclic-nucleotide phosphodiesterase activity//transferase activity//protein dimerization activity//protein binding//DNA-directed DNA polymerase activity//RNA-DNA hybrid ribonuclease activity GO:0042575 DNA polymerase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.39544 BP_3 83.34 3.17 1557 91090428 XP_971598.1 612 1.1e-60 PREDICTED: THO complex subunit 4 [Tribolium castaneum]>gi|270013379|gb|EFA09827.1| hypothetical protein TcasGA2_TC011974 [Tribolium castaneum] -- -- -- -- -- K12881 THOC4, ALY THO complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12881 Q58EA2 383 1.6e-35 THO complex subunit 4-A OS=Xenopus laevis GN=alyref-a PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0097159//GO:1901363//GO:0003676 organic cyclic compound binding//heterocyclic compound binding//nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.39545 BP_3 816.75 16.94 2616 91092368 XP_971937.1 2300 3.4e-256 PREDICTED: dnaJ homolog dnj-5 [Tribolium castaneum] -- -- -- -- -- K09534 DNAJC14 DnaJ homolog subfamily C member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09534 Q921R4 425 3.7e-40 DnaJ homolog subfamily C member 14 OS=Mus musculus GN=Dnajc14 PE=2 SV=2 PF05390 Yeast cell wall synthesis protein KRE9/KNH1 GO:0042546//GO:0006078 cell wall biogenesis//(1->6)-beta-D-glucan biosynthetic process -- -- -- -- KOG0720 Molecular chaperone (DnaJ superfamily) Cluster-8309.39546 BP_3 10.25 1.78 569 642928815 XP_967995.2 308 7.1e-26 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 142 5.2e-08 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39548 BP_3 15.48 0.46 1928 546679644 ERL90075.1 1681 1.5e-184 hypothetical protein D910_07430, partial [Dendroctonus ponderosae] 815900771 XM_012381089.1 72 8.1994e-27 PREDICTED: Bombus impatiens lateral signaling target protein 2 homolog (LOC100747478), transcript variant X2, mRNA -- -- -- -- B0WAQ0 1043 5.9e-112 Lateral signaling target protein 2 homolog OS=Culex quinquefasciatus GN=CPIJ004116 PE=3 SV=1 PF02347 Glycine cleavage system P-protein GO:0006563//GO:0006566//GO:0006544//GO:0006546//GO:0055114 L-serine metabolic process//threonine metabolic process//glycine metabolic process//glycine catabolic process//oxidation-reduction process GO:0004375 glycine dehydrogenase (decarboxylating) activity -- -- KOG1819 FYVE finger-containing proteins Cluster-8309.39549 BP_3 67.41 1.97 1940 741829513 AJA91072.1 1304 7.8e-141 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 852 8.3e-90 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.39550 BP_3 20.69 1.01 1282 642938930 XP_008200093.1 1123 5.0e-120 PREDICTED: LOW QUALITY PROTEIN: probable cytochrome P450 6a23 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 737 1.2e-76 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF04608//PF01040//PF00067//PF15681 Phosphatidylglycerophosphatase A//UbiA prenyltransferase family//Cytochrome P450//Lymphocyte activation family X GO:0006629//GO:0055114//GO:0046486//GO:0051249//GO:0006955 lipid metabolic process//oxidation-reduction process//glycerolipid metabolic process//regulation of lymphocyte activation//immune response GO:0016705//GO:0004659//GO:0020037//GO:0008962//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//prenyltransferase activity//heme binding//phosphatidylglycerophosphatase activity//iron ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.39554 BP_3 497.53 12.95 2143 642912940 XP_008201316.1 286 9.6e-23 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P48594 220 1.8e-16 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 PF09175 Domain of unknown function (DUF1944) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- -- -- Cluster-8309.39555 BP_3 645.30 3.32 9664 642930846 XP_008196111.1 555 2.8e-53 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39556 BP_3 1281.43 9.25 6968 512885476 XP_004921601.1 4075 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX8 [Bombyx mori] 817212638 XM_012427088.1 642 0 PREDICTED: Orussus abietinus ATP-dependent RNA helicase DHX8 (LOC105700863), mRNA K12818 DHX8, PRP22 ATP-dependent RNA helicase DHX8/PRP22 http://www.genome.jp/dbget-bin/www_bget?ko:K12818 A2A4P0 3623 0.0e+00 ATP-dependent RNA helicase DHX8 OS=Mus musculus GN=Dhx8 PE=2 SV=1 PF00575//PF04408//PF14532//PF00005//PF00437//PF07652//PF00270 S1 RNA binding domain//Helicase associated domain (HA2)//Sigma-54 interaction domain//ABC transporter//Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0006355//GO:0006810//GO:0019079 regulation of transcription, DNA-templated//transport//viral genome replication GO:0016887//GO:0003676//GO:0008026//GO:0008134//GO:0004386//GO:0005524 ATPase activity//nucleic acid binding//ATP-dependent helicase activity//transcription factor binding//helicase activity//ATP binding GO:0005667 transcription factor complex KOG0922 DEAH-box RNA helicase Cluster-8309.39557 BP_3 69.38 1.56 2437 100811805 BAE94685.1 2502 1.2e-279 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 748 1.2e-77 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.39558 BP_3 67.99 2.23 1764 478258622 ENN78672.1 343 1.9e-29 hypothetical protein YQE_04844, partial [Dendroctonus ponderosae]>gi|546685778|gb|ERL95227.1| hypothetical protein D910_12494 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q502E5 173 4.1e-11 Small integral membrane protein 8 OS=Danio rerio GN=smim8 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39559 BP_3 3694.66 82.74 2444 642921188 XP_008192753.1 1063 8.7e-113 PREDICTED: reticulon-1-A-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0T0 483 6.4e-47 Reticulon-1 OS=Mus musculus GN=Rtn1 PE=1 SV=1 PF00834 Ribulose-phosphate 3 epimerase family GO:0005975 carbohydrate metabolic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives -- -- KOG1792 Reticulon Cluster-8309.39565 BP_3 2.56 0.45 564 91087491 XP_968373.1 358 1.1e-31 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] -- -- -- -- -- K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 Q5RES5 266 2.1e-22 3-ketoacyl-CoA thiolase, mitochondrial OS=Pongo abelii GN=ACAA2 PE=2 SV=1 PF05923//PF00108 APC cysteine-rich region//Thiolase, N-terminal domain GO:0016055//GO:0008152 Wnt signaling pathway//metabolic process GO:0016747//GO:0016746 transferase activity, transferring acyl groups other than amino-acyl groups//transferase activity, transferring acyl groups -- -- KOG1391 Acetyl-CoA acetyltransferase Cluster-8309.39566 BP_3 2227.85 20.21 5606 91087491 XP_968373.1 1415 3.0e-153 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] 462366872 APGK01027093.1 51 1.13811e-14 Dendroctonus ponderosae Seq01027103, whole genome shotgun sequence K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 P42765 1078 1.5e-115 3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens GN=ACAA2 PE=1 SV=2 PF05699//PF02803//PF00108 hAT family C-terminal dimerisation region//Thiolase, C-terminal domain//Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747//GO:0046983 transferase activity, transferring acyl groups other than amino-acyl groups//protein dimerization activity -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.39567 BP_3 39.00 10.24 475 91087491 XP_968373.1 177 9.2e-11 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] -- -- -- -- -- K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 Q3T0R7 141 5.6e-08 3-ketoacyl-CoA thiolase, mitochondrial OS=Bos taurus GN=ACAA2 PE=2 SV=1 PF02803 Thiolase, C-terminal domain GO:0008152 metabolic process GO:0003824//GO:0016747 catalytic activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1391 Acetyl-CoA acetyltransferase Cluster-8309.39568 BP_3 1044.29 14.11 3860 91077138 XP_971446.1 1025 3.5e-108 PREDICTED: dnaJ homolog subfamily A member 1 [Tribolium castaneum]>gi|270001716|gb|EEZ98163.1| hypothetical protein TcasGA2_TC000590 [Tribolium castaneum] 817197334 XM_012418859.1 104 2.69346e-44 PREDICTED: Orussus abietinus dnaJ homolog subfamily A member 1 (LOC105696421), transcript variant X2, mRNA K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 P63037 769 7.0e-80 DnaJ homolog subfamily A member 1 OS=Mus musculus GN=Dnaja1 PE=1 SV=1 PF00018//PF05209//PF00684//PF16685//PF01155 SH3 domain//Septum formation inhibitor MinC, N-terminal domain//DnaJ central domain//zinc RING finger of MSL2//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006260//GO:0051302//GO:0006457//GO:0006464//GO:0009408 DNA replication//regulation of cell division//protein folding//cellular protein modification process//response to heat GO:0051082//GO:0046872//GO:0005524//GO:0031072//GO:0005515//GO:0016151//GO:0061630 unfolded protein binding//metal ion binding//ATP binding//heat shock protein binding//protein binding//nickel cation binding//ubiquitin protein ligase activity GO:0005737 cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.39570 BP_3 72.71 1.08 3537 642918588 XP_008197437.1 640 1.4e-63 PREDICTED: RNA-binding Raly-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.39571 BP_3 1351.28 6.41 10456 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436//PF07442 NHL repeat//Ponericin -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.39572 BP_3 69.32 1.09 3354 91085467 XP_970131.1 756 4.7e-77 PREDICTED: guanine nucleotide-binding protein subunit beta-1 [Tribolium castaneum]>gi|270008384|gb|EFA04832.1| hypothetical protein TcasGA2_TC014882 [Tribolium castaneum] 768433115 XM_011559611.1 204 6.0114e-100 PREDICTED: Plutella xylostella guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (LOC105388661), transcript variant X2, mRNA K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 P26308 731 1.5e-75 Guanine nucleotide-binding protein subunit beta-1 OS=Drosophila melanogaster GN=Gbeta13F PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.39573 BP_3 52.69 1.23 2352 91085467 XP_970131.1 1348 7.5e-146 PREDICTED: guanine nucleotide-binding protein subunit beta-1 [Tribolium castaneum]>gi|270008384|gb|EFA04832.1| hypothetical protein TcasGA2_TC014882 [Tribolium castaneum] 241655454 XM_002411339.1 361 0 Ixodes scapularis THO complex subunit, putative, mRNA K04538 GNB4 guanine nucleotide-binding protein subunit beta-4 http://www.genome.jp/dbget-bin/www_bget?ko:K04538 O45040 1289 2.1e-140 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homarus americanus GN=GBETA1 PE=2 SV=1 PF03347//PF00400 Vibrio thermostable direct hemolysin//WD domain, G-beta repeat GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515 protein binding GO:0005576 extracellular region KOG0286 G-protein beta subunit Cluster-8309.39574 BP_3 5374.81 143.03 2103 91085467 XP_970131.1 1800 2.6e-198 PREDICTED: guanine nucleotide-binding protein subunit beta-1 [Tribolium castaneum]>gi|270008384|gb|EFA04832.1| hypothetical protein TcasGA2_TC014882 [Tribolium castaneum] 241655454 XM_002411339.1 446 0 Ixodes scapularis THO complex subunit, putative, mRNA K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 P26308 1710 2.9e-189 Guanine nucleotide-binding protein subunit beta-1 OS=Drosophila melanogaster GN=Gbeta13F PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.39575 BP_3 1841.00 110.61 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39576 BP_3 234.75 3.82 3257 478254710 ENN74951.1 1410 6.7e-153 hypothetical protein YQE_08528, partial [Dendroctonus ponderosae] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 363 7.0e-33 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF08777//PF00638//PF00641 RNA binding motif//RanBP1 domain//Zn-finger in Ran binding protein and others GO:0046907 intracellular transport GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.39579 BP_3 391.75 3.58 5567 91091668 XP_971563.1 1168 1.3e-124 PREDICTED: docking protein 2 [Tribolium castaneum]>gi|270001055|gb|EEZ97502.1| hypothetical protein TcasGA2_TC011346 [Tribolium castaneum] -- -- -- -- -- K17808 ZIM17, DNLZ, Tim15 mitochondrial protein import protein ZIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17808 A1L1P7 281 3.9e-23 DNL-type zinc finger protein OS=Danio rerio GN=dnlz PE=2 SV=1 PF05180//PF02174 DNL zinc finger//PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0008270//GO:0005158 zinc ion binding//insulin receptor binding GO:0005899 insulin receptor complex KOG3277 Uncharacterized conserved protein Cluster-8309.39580 BP_3 208.44 3.81 2931 91080237 XP_972872.1 1006 4.2e-106 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39581 BP_3 1.00 1.49 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39582 BP_3 455.38 6.05 3918 805759384 XP_012151679.1 1174 1.9e-125 PREDICTED: protein KRI1 homolog [Megachile rotundata] 820856991 XR_001112512.1 101 1.27215e-42 PREDICTED: Apis florea uncharacterized protein C1orf43 homolog (LOC100869278), transcript variant X3, misc_RNA K14786 KRI1 protein KRI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14786 Q9VTU0 552 1.0e-54 Protein KRI1 homolog OS=Drosophila melanogaster GN=CG5645 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2409 KRR1-interacting protein involved in 40S ribosome biogenesis Cluster-8309.39583 BP_3 2.00 1.17 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39584 BP_3 121.89 19.76 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10798 Biofilm development protein YmgB/AriR GO:0042710//GO:0071229 biofilm formation//cellular response to acid chemical -- -- -- -- -- -- Cluster-8309.39588 BP_3 26.86 0.39 3570 270012474 EFA08922.1 1128 3.7e-120 hypothetical protein TcasGA2_TC006629 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 660 2.8e-67 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF12920//PF10186//PF00498 TcdA/TcdB pore forming domain//Vacuolar sorting 38 and autophagy-related subunit 14//FHA domain GO:0010508//GO:0009405 positive regulation of autophagy//pathogenesis GO:0005515 protein binding -- -- KOG3872 FOG: FHA domain Cluster-8309.39589 BP_3 2921.18 26.56 5593 642917537 XP_008191245.1 5996 0.0e+00 PREDICTED: protein TANC2 isoform X2 [Tribolium castaneum]>gi|642917539|ref|XP_008191246.1| PREDICTED: protein TANC2 isoform X2 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.12745e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.0e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF13639//PF13414//PF02376//PF01637//PF00023//PF00004//PF13606//PF00097//PF07728 Ring finger domain//TPR repeat//CUT domain//Archaeal ATPase//Ankyrin repeat//ATPase family associated with various cellular activities (AAA)//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//AAA domain (dynein-related subfamily) -- -- GO:0016887//GO:0003677//GO:0008270//GO:0005524//GO:0005515//GO:0046872 ATPase activity//DNA binding//zinc ion binding//ATP binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.39590 BP_3 55.00 5.17 804 478255719 ENN75928.1 664 5.3e-67 hypothetical protein YQE_07465, partial [Dendroctonus ponderosae]>gi|546681163|gb|ERL91307.1| hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35502 182 1.7e-12 Esterase FE4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39591 BP_3 497.00 11.61 2355 546678047 ERL88771.1 502 9.4e-48 hypothetical protein D910_06153 [Dendroctonus ponderosae] -- -- -- -- -- K01277 DPP3 dipeptidyl-peptidase III http://www.genome.jp/dbget-bin/www_bget?ko:K01277 Q9VHR8 324 1.7e-28 Dipeptidyl peptidase 3 OS=Drosophila melanogaster GN=DppIII PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3675 Dipeptidyl peptidase III Cluster-8309.39592 BP_3 443.90 1.45 15016 642914247 XP_008201606.1 18680 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10171 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF07645//PF00008//PF00028 Calcium-binding EGF domain//EGF-like domain//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.39595 BP_3 856.90 7.52 5783 270006025 EFA02473.1 1249 5.6e-134 hypothetical protein TcasGA2_TC008164 [Tribolium castaneum] -- -- -- -- -- K14803 PTC2_3 protein phosphatase 2C homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14803 P49596 1031 4.3e-110 Probable protein phosphatase 2C T23F11.1 OS=Caenorhabditis elegans GN=ppm-2 PE=3 SV=2 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.39596 BP_3 520.05 7.59 3594 642919707 XP_008192031.1 344 3.0e-29 PREDICTED: cleavage and polyadenylation specificity factor subunit CG7185 [Tribolium castaneum] -- -- -- -- -- K14398 CPSF6_7 cleavage and polyadenylation specificity factor subunit 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14398 Q9VSH4 312 6.4e-27 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4849 mRNA cleavage factor I subunit/CPSF subunit Cluster-8309.39597 BP_3 52.00 7.32 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39598 BP_3 99.64 8.76 840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39599 BP_3 700.74 9.65 3793 642933627 XP_008197501.1 1527 2.1e-166 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [Tribolium castaneum] 676386870 XM_009038466.1 51 7.67666e-15 Aureococcus anophagefferens hypothetical protein partial mRNA K01110 PTEN phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN http://www.genome.jp/dbget-bin/www_bget?ko:K01110 P60484 854 9.5e-90 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens GN=PTEN PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004721//GO:0008138//GO:0004725 phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases Cluster-8309.39600 BP_3 5246.75 71.63 3822 259013492 NP_001158490.1 1405 3.0e-152 casein kinase 1, alpha 1 [Saccoglossus kowalevskii]>gi|197734685|gb|ACH73238.1| casein kinase 1 protein catalytic subunit [Saccoglossus kowalevskii] 768410303 XM_011559102.1 355 0 PREDICTED: Plutella xylostella casein kinase I isoform alpha-like (LOC105388216), transcript variant X2, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67827 1401 3.6e-153 Casein kinase I isoform alpha OS=Bos taurus GN=CSNK1A1 PE=1 SV=1 PF07714//PF00069//PF05445//PF00180 Protein tyrosine kinase//Protein kinase domain//Poxvirus serine/threonine protein kinase//Isocitrate/isopropylmalate dehydrogenase GO:0006468//GO:0009069//GO:0016310//GO:0055114 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//oxidation-reduction process GO:0016616//GO:0005524//GO:0004674//GO:0004672 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.39601 BP_3 3128.03 36.48 4425 259013492 NP_001158490.1 1405 3.5e-152 casein kinase 1, alpha 1 [Saccoglossus kowalevskii]>gi|197734685|gb|ACH73238.1| casein kinase 1 protein catalytic subunit [Saccoglossus kowalevskii] 768410303 XM_011559102.1 355 0 PREDICTED: Plutella xylostella casein kinase I isoform alpha-like (LOC105388216), transcript variant X2, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67827 1401 4.1e-153 Casein kinase I isoform alpha OS=Bos taurus GN=CSNK1A1 PE=1 SV=1 PF07714//PF00069//PF07850//PF05445//PF00180 Protein tyrosine kinase//Protein kinase domain//Renin receptor-like protein//Poxvirus serine/threonine protein kinase//Isocitrate/isopropylmalate dehydrogenase GO:0055114//GO:0006468//GO:0009069//GO:0016310//GO:0007165 oxidation-reduction process//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//signal transduction GO:0004674//GO:0004672//GO:0016616//GO:0004872//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//receptor activity//ATP binding GO:0016021 integral component of membrane KOG1163 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.39603 BP_3 2247.00 38.66 3093 91075936 XP_967560.1 3824 0.0e+00 PREDICTED: 26S proteasome non-ATPase regulatory subunit 2 [Tribolium castaneum]>gi|270014631|gb|EFA11079.1| hypothetical protein TcasGA2_TC004675 [Tribolium castaneum] 751232490 XM_011171561.1 352 0 PREDICTED: Solenopsis invicta 26S proteasome non-ATPase regulatory subunit 2 (LOC105202874), mRNA K03028 PSMD2, RPN1 26S proteasome regulatory subunit N1 http://www.genome.jp/dbget-bin/www_bget?ko:K03028 Q13200 3016 0.0e+00 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 -- -- GO:0042176//GO:0050790 regulation of protein catabolic process//regulation of catalytic activity GO:0030234 enzyme regulator activity GO:0000502 proteasome complex KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2 Cluster-8309.39604 BP_3 100.56 0.85 5966 91083631 XP_970382.1 3673 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 2.37549e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2881 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF00205//PF01752//PF02826//PF03188//PF02233//PF00005//PF07074//PF00107 Thiamine pyrophosphate enzyme, central domain//Collagenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//NAD(P) transhydrogenase beta subunit//ABC transporter//Translocon-associated protein, gamma subunit (TRAP-gamma)//Zinc-binding dehydrogenase GO:0006508//GO:0006769//GO:0015992//GO:0055114//GO:0046497//GO:0006613 proteolysis//nicotinamide metabolic process//proton transport//oxidation-reduction process//nicotinate nucleotide metabolic process//cotranslational protein targeting to membrane GO:0000287//GO:0030976//GO:0051287//GO:0050661//GO:0004252//GO:0016887//GO:0008270//GO:0008750//GO:0005524 magnesium ion binding//thiamine pyrophosphate binding//NAD binding//NADP binding//serine-type endopeptidase activity//ATPase activity//zinc ion binding//NAD(P)+ transhydrogenase (AB-specific) activity//ATP binding GO:0005576//GO:0005784//GO:0030176//GO:0016021 extracellular region//Sec61 translocon complex//integral component of endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.39605 BP_3 369.08 4.30 4433 642917718 XP_008191344.1 3290 0.0e+00 PREDICTED: ecotropic viral integration site 5 ortholog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VYY9 2192 7.9e-245 Ecotropic viral integration site 5 ortholog OS=Drosophila melanogaster GN=Evi5 PE=1 SV=3 PF10605//PF13013 3HB-oligomer hydrolase (3HBOH)//F-box-like domain GO:0019605 butyrate metabolic process GO:0005515//GO:0047989 protein binding//hydroxybutyrate-dimer hydrolase activity GO:0005615 extracellular space KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.39609 BP_3 105.86 2.24 2569 283046730 NP_001164311.1 1663 2.4e-182 tyramine/octopamine receptor [Tribolium castaneum]>gi|289191348|ref|NP_001164312.1| tyramine/octopamine receptor [Tribolium castaneum]>gi|642912074|ref|XP_008200790.1| PREDICTED: tyramine/octopamine receptor isoform X1 [Tribolium castaneum]>gi|270002886|gb|EEZ99333.1| hypothetical protein TcasGA2_TC004545 [Tribolium castaneum]>gi|485836728|tpg|DAA64498.1| TPA_inf: putative octopamine/tyramine receptor [Tribolium castaneum] 118782661 XM_312420.3 177 4.69094e-85 Anopheles gambiae str. PEST AGAP002519-PA (GPRTYR) mRNA, complete cds K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25188 1303 5.6e-142 Octopamine receptor OS=Heliothis virescens PE=2 SV=1 PF00001//PF08496//PF02480//PF01496 7 transmembrane receptor (rhodopsin family)//Peptidase family S49 N-terminal//Alphaherpesvirus glycoprotein E//V-type ATPase 116kDa subunit family GO:0007186//GO:0015992//GO:0007187//GO:0015991 G-protein coupled receptor signaling pathway//proton transport//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//ATP hydrolysis coupled proton transport GO:0015078//GO:0004252//GO:0004989//GO:0004930 hydrogen ion transmembrane transporter activity//serine-type endopeptidase activity//octopamine receptor activity//G-protein coupled receptor activity GO:0016020//GO:0033179//GO:0016021//GO:0005886 membrane//proton-transporting V-type ATPase, V0 domain//integral component of membrane//plasma membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.39612 BP_3 15.00 1.98 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39614 BP_3 242.16 0.42 27920 642928700 XP_008199744.1 29002 0.0e+00 PREDICTED: dystonin isoform X7 [Tribolium castaneum] 642928701 XM_008201523.1 1042 0 PREDICTED: Tribolium castaneum microtubule-actin cross-linking factor 1 (LOC662585), transcript variant X8, mRNA -- -- -- -- Q03001 4157 0.0e+00 Dystonin OS=Homo sapiens GN=DST PE=1 SV=4 PF07726//PF00270//PF00910//PF00608//PF00997//PF13465//PF14532//PF05496//PF00435//PF00628//PF06068//PF13520//PF06160//PF02367//PF00307//PF01695//PF07728//PF00681//PF00158//PF00004//PF06005 ATPase family associated with various cellular activities (AAA)//DEAD/DEAH box helicase//RNA helicase//Adenoviral fibre protein (repeat/shaft region)//Kappa casein//Zinc-finger double domain//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//Spectrin repeat//PHD-finger//TIP49 C-terminus//Amino acid permease//Septation ring formation regulator, EzrA//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Calponin homology (CH) domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Plectin repeat//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Protein of unknown function (DUF904) GO:0006865//GO:0000921//GO:0003333//GO:0002949//GO:0006310//GO:0019062//GO:0007155//GO:0043093//GO:0000917//GO:0009405//GO:0006281//GO:0006355 amino acid transport//septin ring assembly//amino acid transmembrane transport//tRNA threonylcarbamoyladenosine modification//DNA recombination//virion attachment to host cell//cell adhesion//FtsZ-dependent cytokinesis//barrier septum assembly//pathogenesis//DNA repair//regulation of transcription, DNA-templated GO:0003678//GO:0003676//GO:0046872//GO:0005524//GO:0008134//GO:0016887//GO:0003723//GO:0005515//GO:0009378//GO:0003724//GO:0015171 DNA helicase activity//nucleic acid binding//metal ion binding//ATP binding//transcription factor binding//ATPase activity//RNA binding//protein binding//four-way junction helicase activity//RNA helicase activity//amino acid transmembrane transporter activity GO:0005667//GO:0005856//GO:0005657//GO:0016020//GO:0005576//GO:0016021//GO:0009379//GO:0005940//GO:0005737 transcription factor complex//cytoskeleton//replication fork//membrane//extracellular region//integral component of membrane//Holliday junction helicase complex//septin ring//cytoplasm KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.39615 BP_3 9524.48 16.65 27861 642928690 XP_008199739.1 28942 0.0e+00 PREDICTED: dystonin isoform X2 [Tribolium castaneum] 642928705 XM_008201526.1 1000 0 PREDICTED: Tribolium castaneum microtubule-actin cross-linking factor 1 (LOC662585), transcript variant X10, mRNA -- -- -- -- Q03001 4157 0.0e+00 Dystonin OS=Homo sapiens GN=DST PE=1 SV=4 PF00307//PF02367//PF06160//PF06005//PF00004//PF00158//PF07728//PF00681//PF01695//PF00608//PF13465//PF00997//PF00910//PF00270//PF07726//PF13520//PF00628//PF06068//PF05496//PF00435//PF14532 Calponin homology (CH) domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Septation ring formation regulator, EzrA//Protein of unknown function (DUF904)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//Plectin repeat//IstB-like ATP binding protein//Adenoviral fibre protein (repeat/shaft region)//Zinc-finger double domain//Kappa casein//RNA helicase//DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Amino acid permease//PHD-finger//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Spectrin repeat//Sigma-54 interaction domain GO:0000917//GO:0043093//GO:0007155//GO:0019062//GO:0006355//GO:0006281//GO:0009405//GO:0006310//GO:0002949//GO:0003333//GO:0000921//GO:0006865 barrier septum assembly//FtsZ-dependent cytokinesis//cell adhesion//virion attachment to host cell//regulation of transcription, DNA-templated//DNA repair//pathogenesis//DNA recombination//tRNA threonylcarbamoyladenosine modification//amino acid transmembrane transport//septin ring assembly//amino acid transport GO:0003724//GO:0009378//GO:0005515//GO:0003723//GO:0015171//GO:0046872//GO:0003676//GO:0003678//GO:0016887//GO:0008134//GO:0005524 RNA helicase activity//four-way junction helicase activity//protein binding//RNA binding//amino acid transmembrane transporter activity//metal ion binding//nucleic acid binding//DNA helicase activity//ATPase activity//transcription factor binding//ATP binding GO:0005576//GO:0016020//GO:0005657//GO:0005856//GO:0005737//GO:0005940//GO:0009379//GO:0016021//GO:0005667 extracellular region//membrane//replication fork//cytoskeleton//cytoplasm//septin ring//Holliday junction helicase complex//integral component of membrane//transcription factor complex KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.39616 BP_3 1073.32 25.79 2298 546684894 ERL94476.1 1195 4.0e-128 hypothetical protein D910_11753 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H3P7 604 5.6e-61 Golgi resident protein GCP60 OS=Homo sapiens GN=ACBD3 PE=1 SV=4 PF00887//PF13897 Acyl CoA binding protein//Golgi-dynamics membrane-trafficking GO:0006810 transport GO:0000062 fatty-acyl-CoA binding GO:0016021 integral component of membrane KOG3878 Protein involved in maintenance of Golgi structure and ER-Golgi transport Cluster-8309.39617 BP_3 310.33 2.09 7446 642930792 XP_008196093.1 1047 1.9e-110 PREDICTED: ski oncogene [Tribolium castaneum] 759170310 XM_011377342.1 126 3.07386e-56 PREDICTED: Pteropus vampyrus SKI proto-oncogene (SKI), partial mRNA K18499 SKIL Ski-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K18499 P17863 674 1.4e-68 Transforming protein Ski OS=Avian erythroblastosis virus (strain Sloan-Kettering) GN=V-SKI PE=1 SV=1 PF08782//PF04501//PF11365 c-SKI Smad4 binding domain//Baculovirus major capsid protein VP39//Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy GO:0046332//GO:0005198 SMAD binding//structural molecule activity GO:0005615//GO:0019028 extracellular space//viral capsid -- -- Cluster-8309.39618 BP_3 120.87 0.75 8093 270011987 EFA08435.1 1048 1.6e-110 hypothetical protein TcasGA2_TC006082 [Tribolium castaneum] 759170310 XM_011377342.1 126 3.34229e-56 PREDICTED: Pteropus vampyrus SKI proto-oncogene (SKI), partial mRNA K18499 SKIL Ski-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K18499 P17863 674 1.5e-68 Transforming protein Ski OS=Avian erythroblastosis virus (strain Sloan-Kettering) GN=V-SKI PE=1 SV=1 PF08782//PF04501//PF11365 c-SKI Smad4 binding domain//Baculovirus major capsid protein VP39//Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy GO:0046332//GO:0005198 SMAD binding//structural molecule activity GO:0019028//GO:0005615 viral capsid//extracellular space -- -- Cluster-8309.39619 BP_3 162.69 0.98 8255 56756172 CAH65679.2 2465 7.9e-275 acetylcholinesterase precursor [Nilaparvata lugens] 642913509 XM_008202822.1 782 0 PREDICTED: Tribolium castaneum acetylcholinesterase 2 (LOC659368), mRNA K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 Q27677 3038 0.0e+00 Acetylcholinesterase OS=Leptinotarsa decemlineata PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG4389 Acetylcholinesterase/Butyrylcholinesterase Cluster-8309.39620 BP_3 3036.65 57.08 2856 332376452 AEE63366.1 839 9.6e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08360 CYB561 cytochrome b-561 http://www.genome.jp/dbget-bin/www_bget?ko:K08360 P34465 448 8.6e-43 Putative cytochrome b561 OS=Caenorhabditis elegans GN=F55H2.5 PE=3 SV=1 PF01292//PF03188//PF03124 Prokaryotic cytochrome b561//Eukaryotic cytochrome b561//EXS family GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane KOG1619 Cytochrome b Cluster-8309.39624 BP_3 857.52 16.92 2734 642925558 XP_008194598.1 1219 7.9e-131 PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925560|ref|XP_008194599.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925562|ref|XP_008194600.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|270008677|gb|EFA05125.1| hypothetical protein TcasGA2_TC015240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6Q4G4 345 7.2e-31 Angiotensin-converting enzyme OS=Theromyzon tessulatum GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.39626 BP_3 31808.00 3427.68 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39627 BP_3 2631.97 20.08 6609 549438543 AGX25160.1 1445 1.2e-156 cathepsin B precursor [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9GZM7 895 2.9e-94 Tubulointerstitial nephritis antigen-like OS=Homo sapiens GN=TINAGL1 PE=1 SV=1 PF00112//PF03051//PF04218 Papain family cysteine protease//Peptidase C1-like family//CENP-B N-terminal DNA-binding domain GO:0006508 proteolysis GO:0003677//GO:0008234//GO:0004197 DNA binding//cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.39628 BP_3 513.70 9.43 2917 91090210 XP_967762.1 1212 5.5e-130 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P09875 423 7.0e-40 UDP-glucuronosyltransferase 2B1 OS=Rattus norvegicus GN=Ugt2b1 PE=2 SV=1 PF10660//PF04101//PF00201//PF01708 Iron-containing outer mitochondrial membrane protein N-terminus//Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Geminivirus putative movement protein GO:0046740//GO:0008152 transport of virus in host, cell to cell//metabolic process GO:0016757//GO:0051537//GO:0016758 transferase activity, transferring glycosyl groups//2 iron, 2 sulfur cluster binding//transferase activity, transferring hexosyl groups GO:0016021//GO:0043231 integral component of membrane//intracellular membrane-bounded organelle -- -- Cluster-8309.39629 BP_3 66.83 0.38 8872 546685142 ERL94669.1 5047 0.0e+00 hypothetical protein D910_11944 [Dendroctonus ponderosae] 665804316 XM_008552072.1 92 2.91492e-37 PREDICTED: Microplitis demolitor neuroglian (LOC103573142), mRNA -- -- -- -- P20241 3670 0.0e+00 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF05864//PF06553//PF01108//PF13895//PF00041//PF16656//PF02979 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//BNIP3//Tissue factor//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Nitrile hydratase, alpha chain GO:0006144//GO:0006351//GO:0006807//GO:0006206//GO:0006771//GO:0019497//GO:0043065 purine nucleobase metabolic process//transcription, DNA-templated//nitrogen compound metabolic process//pyrimidine nucleobase metabolic process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//positive regulation of apoptotic process GO:0005515//GO:0003677//GO:0003824//GO:0046914//GO:0046872//GO:0003899//GO:0003993 protein binding//DNA binding//catalytic activity//transition metal ion binding//metal ion binding//DNA-directed RNA polymerase activity//acid phosphatase activity GO:0016021//GO:0005730//GO:0005740 integral component of membrane//nucleolus//mitochondrial envelope KOG3513 Neural cell adhesion molecule L1 Cluster-8309.39630 BP_3 2793.44 21.20 6642 91076984 XP_975463.1 1520 2.4e-165 PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913260|ref|XP_008201461.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913262|ref|XP_008201462.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|270001993|gb|EEZ98440.1| hypothetical protein TcasGA2_TC000929 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97379 482 2.3e-46 Ras GTPase-activating protein-binding protein 2 OS=Mus musculus GN=G3bp2 PE=1 SV=2 PF15886//PF16367//PF00076//PF02136 Carbohydrate binding domain (family 32)//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Nuclear transport factor 2 (NTF2) domain GO:0006810 transport GO:0003676//GO:0030246 nucleic acid binding//carbohydrate binding GO:0005622 intracellular KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains Cluster-8309.39631 BP_3 145.29 3.19 2486 270007205 EFA03653.1 2111 2.7e-234 hypothetical protein TcasGA2_TC013747 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 P83740 1484 5.5e-163 Putative sodium-dependent multivitamin transporter OS=Drosophila melanogaster GN=CG32669 PE=2 SV=1 PF00474//PF01781//PF10716 Sodium:solute symporter family//Ribosomal L38e protein family//NADH dehydrogenase transmembrane subunit GO:0055085//GO:0006412//GO:0006810//GO:0006118//GO:0055114//GO:0042254 transmembrane transport//translation//transport//obsolete electron transport//oxidation-reduction process//ribosome biogenesis GO:0005215//GO:0003735//GO:0016655 transporter activity//structural constituent of ribosome//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005840//GO:0005622//GO:0016020 ribosome//intracellular//membrane -- -- Cluster-8309.39633 BP_3 1723.90 9.61 8940 642911235 XP_008199694.1 6755 0.0e+00 PREDICTED: laminin subunit beta-1 [Tribolium castaneum] 198455549 XM_001360008.2 44 1.41582e-10 Drosophila pseudoobscura pseudoobscura GA20347 (Dpse\GA20347), partial mRNA K05636 LAMB1 laminin, beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05636 P11046 4487 0.0e+00 Laminin subunit beta-1 OS=Drosophila melanogaster GN=LanB1 PE=1 SV=4 PF05384//PF01133//PF00874//PF10440//PF00089//PF05007//PF03554 Sensor protein DegS//Enhancer of rudimentary//PRD domain//Ubiquitin-binding WIYLD domain//Trypsin//Mannosyltransferase (PIG-M)//UL73 viral envelope glycoprotein GO:0006554//GO:0007049//GO:0006479//GO:0006508//GO:0006506//GO:0006355//GO:0045747//GO:0007165//GO:0006221 lysine catabolic process//cell cycle//protein methylation//proteolysis//GPI anchor biosynthetic process//regulation of transcription, DNA-templated//positive regulation of Notch signaling pathway//signal transduction//pyrimidine nucleotide biosynthetic process GO:0004252//GO:0016301//GO:0018024//GO:0016758 serine-type endopeptidase activity//kinase activity//histone-lysine N-methyltransferase activity//transferase activity, transferring hexosyl groups GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0994 Extracellular matrix glycoprotein Laminin subunit beta Cluster-8309.39635 BP_3 321.88 1.40 11353 642933491 XP_008197440.1 3273 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 211 2.63256e-103 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1887 4.7e-209 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain GO:0008152 metabolic process GO:0003824//GO:0019843//GO:0003723 catalytic activity//rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.39636 BP_3 347.76 1.34 12797 817208819 XP_012280436.1 6887 0.0e+00 PREDICTED: uncharacterized protein LOC105699757 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q9U943 866 1.3e-90 Apolipophorins OS=Locusta migratoria PE=1 SV=2 PF09172//PF01347//PF06448 Domain of unknown function (DUF1943)//Lipoprotein amino terminal region//Domain of Unknown Function (DUF1081) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- KOG4338 Predicted lipoprotein Cluster-8309.39638 BP_3 360.14 2.25 8010 91083409 XP_968752.1 826 8.6e-85 PREDICTED: sodium/potassium/calcium exchanger 4 [Tribolium castaneum]>gi|270006894|gb|EFA03342.1| hypothetical protein TcasGA2_TC013319 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q8NFF2 545 1.4e-53 Sodium/potassium/calcium exchanger 4 OS=Homo sapiens GN=SLC24A4 PE=1 SV=2 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.39639 BP_3 194.79 2.55 3977 270007709 EFA04157.1 2983 0.0e+00 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1117 3.2e-120 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF02705//PF13304//PF00005//PF03193 ABC transporter transmembrane region//K+ potassium transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 GO:0055085//GO:0006810//GO:0006813//GO:0071805 transmembrane transport//transport//potassium ion transport//potassium ion transmembrane transport GO:0016887//GO:0005525//GO:0042626//GO:0015079//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//potassium ion transmembrane transporter activity//ATP binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.39642 BP_3 664.27 21.79 1761 642912068 XP_008200785.1 1450 8.3e-158 PREDICTED: peroxidase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 1.8e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.39644 BP_3 3889.76 69.64 2984 546673984 ERL85488.1 866 7.4e-90 hypothetical protein D910_02907 [Dendroctonus ponderosae] 506968668 KC740854.1 184 7.00754e-89 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 776 8.3e-81 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.39645 BP_3 1278.08 18.33 3652 91086631 XP_966390.1 1735 1.6e-190 PREDICTED: abhydrolase domain-containing protein 2 [Tribolium castaneum]>gi|270010379|gb|EFA06827.1| hypothetical protein TcasGA2_TC009769 [Tribolium castaneum] -- -- -- -- -- K13697 ABHD2 abhydrolase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13697 Q24093 1475 9.0e-162 Abhydrolase domain-containing protein 2 OS=Drosophila melanogaster GN=Hydr2 PE=2 SV=2 PF01764//PF00326//PF02230//PF01738//PF01083 Lipase (class 3)//Prolyl oligopeptidase family//Phospholipase/Carboxylesterase//Dienelactone hydrolase family//Cutinase GO:0008152//GO:0006508//GO:0006629 metabolic process//proteolysis//lipid metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG1838 Alpha/beta hydrolase Cluster-8309.39646 BP_3 458.32 2.51 9095 642914109 XP_008201547.1 3881 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12923 427 7.5e-40 Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2 PF00595//PF02873//PF13180//PF08997 PDZ domain (Also known as DHR or GLGF)//UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain//PDZ domain//Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0055114//GO:0015992//GO:0006118//GO:0006119//GO:0006040 oxidation-reduction process//proton transport//obsolete electron transport//oxidative phosphorylation//amino sugar metabolic process GO:0009055//GO:0008762//GO:0005515//GO:0008121 electron carrier activity//UDP-N-acetylmuramate dehydrogenase activity//protein binding//ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.39648 BP_3 397.63 12.32 1847 91082161 XP_970591.1 1226 8.2e-132 PREDICTED: reticulocalbin-2 [Tribolium castaneum]>gi|270007433|gb|EFA03881.1| hypothetical protein TcasGA2_TC014005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X186 510 3.6e-50 Calumenin-A OS=Salmo salar GN=calua PE=2 SV=1 PF13405//PF10591//PF00036//PF13833//PF13499//PF13202//PF12763 EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain pair//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.39650 BP_3 193.74 2.69 3766 270014029 EFA10477.1 699 2.2e-70 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 1.25743e-22 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- Q5R6A9 173 8.8e-11 TOX high mobility group box family member 4 OS=Pongo abelii GN=TOX4 PE=2 SV=2 PF11770//PF03460 GRB2-binding adapter (GAPT)//Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.39651 BP_3 15.83 0.38 2299 91076006 XP_966406.1 2269 1.2e-252 PREDICTED: very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014595|gb|EFA11043.1| hypothetical protein TcasGA2_TC004634 [Tribolium castaneum] 676425561 XM_009046107.1 184 5.38333e-89 Lottia gigantea hypothetical protein partial mRNA K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 Q8HXY7 1652 1.7e-182 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Macaca fascicularis GN=ACADVL PE=2 SV=1 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.39652 BP_3 170.60 1.53 5659 91080669 XP_975087.1 970 1.2e-101 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 746866518 XM_011066023.1 149 3.82295e-69 PREDICTED: Acromyrmex echinatior vesicle-trafficking protein SEC22b (LOC105152004), transcript variant X3, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 719 6.4e-74 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.39654 BP_3 212.41 1.79 6019 642936708 XP_008198548.1 756 8.5e-77 PREDICTED: tRNA pseudouridine synthase-like 1 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 420 3.2e-39 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF01416//PF02868//PF00782//PF01529//PF00102//PF08777//PF04179 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA pseudouridine synthase//Thermolysin metallopeptidase, alpha-helical domain//Dual specificity phosphatase, catalytic domain//DHHC palmitoyltransferase//Protein-tyrosine phosphatase//RNA binding motif//Initiator tRNA phosphoribosyl transferase GO:0006470//GO:0006570//GO:0019988//GO:0001522//GO:0009451 protein dephosphorylation//tyrosine metabolic process//charged-tRNA amino acid modification//pseudouridine synthesis//RNA modification GO:0008138//GO:0004725//GO:0043399//GO:0003723//GO:0004222//GO:0003676//GO:0009982//GO:0008270 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity//RNA binding//metalloendopeptidase activity//nucleic acid binding//pseudouridine synthase activity//zinc ion binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.39657 BP_3 1275.37 8.98 7140 91089729 XP_975072.1 3304 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|642933644|ref|XP_008197508.1| PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|270011308|gb|EFA07756.1| hypothetical protein TcasGA2_TC005310 [Tribolium castaneum] -- -- -- -- -- K05016 CLCN7 chloride channel 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05016 P51798 1914 2.2e-212 H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens GN=CLCN7 PE=1 SV=2 PF09726//PF10473//PF05024//PF07926//PF13326//PF00769//PF08702//PF15191//PF15898//PF04111//PF00709//PF00170//PF03790//PF00654//PF13851 Transmembrane protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//N-acetylglucosaminyl transferase component (Gpi1)//TPR/MLP1/MLP2-like protein//Photosystem II Pbs27//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Synaptonemal complex central element protein 3//cGMP-dependent protein kinase interacting domain//Autophagy protein Apg6//Adenylosuccinate synthetase//bZIP transcription factor//KNOX1 domain//Voltage gated chloride channel//Growth-arrest specific micro-tubule binding GO:0006164//GO:0055085//GO:0006606//GO:0006531//GO:0048870//GO:0010207//GO:0030168//GO:0006914//GO:0051258//GO:0007165//GO:0007283//GO:0006355//GO:0007131//GO:0006144//GO:0006821//GO:0007130//GO:0006522//GO:0006506 purine nucleotide biosynthetic process//transmembrane transport//protein import into nucleus//aspartate metabolic process//cell motility//photosystem II assembly//platelet activation//autophagy//protein polymerization//signal transduction//spermatogenesis//regulation of transcription, DNA-templated//reciprocal meiotic recombination//purine nucleobase metabolic process//chloride transport//synaptonemal complex assembly//alanine metabolic process//GPI anchor biosynthetic process GO:0045502//GO:0008134//GO:0003700//GO:0005102//GO:0008092//GO:0004019//GO:0030674//GO:0043565//GO:0019901//GO:0005247//GO:0017176//GO:0003677//GO:0005525//GO:0042803 dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//receptor binding//cytoskeletal protein binding//adenylosuccinate synthase activity//protein binding, bridging//sequence-specific DNA binding//protein kinase binding//voltage-gated chloride channel activity//phosphatidylinositol N-acetylglucosaminyltransferase activity//DNA binding//GTP binding//protein homodimerization activity GO:0019898//GO:0005577//GO:0005667//GO:0030286//GO:0016021//GO:0031514//GO:0005737//GO:0005634//GO:0016020 extrinsic component of membrane//fibrinogen complex//transcription factor complex//dynein complex//integral component of membrane//motile cilium//cytoplasm//nucleus//membrane KOG0474 Cl- channel CLC-7 and related proteins (CLC superfamily) Cluster-8309.39659 BP_3 78.65 0.54 7321 642929299 XP_008195778.1 5686 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 3840 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF00647//PF00223//PF10152//PF00514 Elongation factor 1 gamma, conserved domain//Photosystem I psaA/psaB protein//Predicted coiled-coil domain-containing protein (DUF2360)//Armadillo/beta-catenin-like repeat GO:0006448//GO:0015979//GO:0006414 regulation of translational elongation//photosynthesis//translational elongation GO:0003746//GO:0005515 translation elongation factor activity//protein binding GO:0009579//GO:0071203//GO:0005840//GO:0009522//GO:0016021 thylakoid//WASH complex//ribosome//photosystem I//integral component of membrane KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.39661 BP_3 554.37 3.07 8993 642916202 XP_008190929.1 540 1.4e-51 PREDICTED: uncharacterized protein LOC103312333 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q59SG9 137 3.1e-06 Probable GPI-anchored adhesin-like protein PGA55 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PGA55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39663 BP_3 2037.97 92.65 1352 755989638 XP_011312250.1 821 5.5e-85 PREDICTED: eukaryotic translation initiation factor 2 subunit 2 [Fopius arisanus] 815925611 XM_003493657.2 170 1.89809e-81 PREDICTED: Bombus impatiens eukaryotic translation initiation factor 2 subunit 2 (LOC100741877), mRNA K03238 EIF2S2 translation initiation factor 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03238 Q99L45 735 2.1e-76 Eukaryotic translation initiation factor 2 subunit 2 OS=Mus musculus GN=Eif2s2 PE=1 SV=1 PF01873 Domain found in IF2B/IF5 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG2768 Translation initiation factor 2, beta subunit (eIF-2beta) Cluster-8309.39664 BP_3 480.71 7.60 3342 270000870 EEZ97317.1 1789 7.8e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.34514e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.5e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.39665 BP_3 49.92 0.89 2987 91090214 XP_967924.1 1528 1.3e-166 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 652 2.0e-66 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.39666 BP_3 564.28 8.85 3365 91092160 XP_967690.1 893 6.2e-93 PREDICTED: RNA-binding protein 24-B [Tribolium castaneum]>gi|270014448|gb|EFA10896.1| hypothetical protein TcasGA2_TC001720 [Tribolium castaneum] 645005484 XM_001606127.3 101 1.09093e-42 PREDICTED: Nasonia vitripennis RNA-binding protein 24-A-like (LOC100122565), transcript variant X3, mRNA -- -- -- -- Q6GQD3 445 2.3e-42 RNA-binding protein 24-A OS=Xenopus laevis GN=rbm24-a PE=2 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily) Cluster-8309.39668 BP_3 13.61 0.41 1891 642937495 XP_008198863.1 154 1.7e-07 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00956//PF00765 Nucleosome assembly protein (NAP)//Autoinducer synthase GO:0006334 nucleosome assembly GO:0016740 transferase activity GO:0005634 nucleus -- -- Cluster-8309.39671 BP_3 24.69 0.61 2240 642937453 XP_008198842.1 569 1.5e-55 PREDICTED: protein tramtrack, beta isoform-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39672 BP_3 1382.02 19.56 3698 642937495 XP_008198863.1 967 1.8e-101 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] 462328819 APGK01040556.1 149 2.48971e-69 Dendroctonus ponderosae Seq01040566, whole genome shotgun sequence -- -- -- -- Q86B87 360 1.8e-32 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.39673 BP_3 35.44 0.97 2061 642937449 XP_008198840.1 563 7.0e-55 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39676 BP_3 548.10 8.41 3432 642929344 XP_008195795.1 1865 1.2e-205 PREDICTED: AMP deaminase 2 isoform X6 [Tribolium castaneum]>gi|270009636|gb|EFA06084.1| hypothetical protein TcasGA2_TC008921 [Tribolium castaneum] 194769475 XM_001966794.1 279 1.24967e-141 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 1107 4.0e-119 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0006144//GO:0006188//GO:0009168//GO:0055114//GO:0006807 purine nucleobase metabolic process//IMP biosynthetic process//purine ribonucleoside monophosphate biosynthetic process//oxidation-reduction process//nitrogen compound metabolic process GO:0016491//GO:0019239//GO:0003876//GO:0046872 oxidoreductase activity//deaminase activity//AMP deaminase activity//metal ion binding -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.39678 BP_3 514.33 7.14 3763 642930759 XP_008196081.1 256 5.1e-19 PREDICTED: sialin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39679 BP_3 1546.74 7.58 10130 270003787 EFA00235.1 2422 9.4e-270 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 462304009 APGK01049651.1 110 3.28319e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 871 2.7e-91 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF13895//PF00041//PF16656//PF08176//PF01637//PF03193//PF02899//PF00005//PF03931//PF01926//PF13304//PF01061//PF07714//PF00069//PF00621 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Small acid-soluble spore protein K family//Archaeal ATPase//Protein of unknown function, DUF258//Phage integrase, N-terminal SAM-like domain//ABC transporter//Skp1 family, tetramerisation domain//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC-2 type transporter//Protein tyrosine kinase//Protein kinase domain//RhoGEF domain GO:0035023//GO:0019497//GO:0006468//GO:0030436//GO:0006771//GO:0043087//GO:0006511//GO:0015074 regulation of Rho protein signal transduction//hexachlorocyclohexane metabolic process//protein phosphorylation//asexual sporulation//riboflavin metabolic process//regulation of GTPase activity//ubiquitin-dependent protein catabolic process//DNA integration GO:0005524//GO:0003924//GO:0016887//GO:0003993//GO:0003677//GO:0005515//GO:0005525//GO:0046872//GO:0004672//GO:0005089 ATP binding//GTPase activity//ATPase activity//acid phosphatase activity//DNA binding//protein binding//GTP binding//metal ion binding//protein kinase activity//Rho guanyl-nucleotide exchange factor activity GO:0042601//GO:0016020 endospore-forming forespore//membrane -- -- Cluster-8309.39680 BP_3 80.75 6.01 939 478250090 ENN70596.1 1091 1.9e-116 hypothetical protein YQE_12771, partial [Dendroctonus ponderosae] -- -- -- -- -- K05701 TJP1, ZO1 tight junction protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05701 O97758 168 8.3e-11 Tight junction protein ZO-1 OS=Canis familiaris GN=TJP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3580 Tight junction proteins Cluster-8309.39682 BP_3 419.26 4.74 4559 270013465 EFA09913.1 1341 9.4e-145 hypothetical protein TcasGA2_TC012064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02663 568 1.7e-56 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.39683 BP_3 21.86 1.03 1318 91094851 XP_972051.1 1070 7.2e-114 PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating [Tribolium castaneum]>gi|270006577|gb|EFA03025.1| hypothetical protein TcasGA2_TC010448 [Tribolium castaneum] 440206336 JQ787165.1 77 9.23365e-30 Metanomeuta fulvicrinis voucher Cvag phosphogluconate dehydrogenase mRNA, partial cds K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00033 P41570 884 1.1e-93 6-phosphogluconate dehydrogenase, decarboxylating OS=Ceratitis capitata GN=Pgd PE=2 SV=1 PF00393 6-phosphogluconate dehydrogenase, C-terminal domain GO:0019521//GO:0006098//GO:0055114 D-gluconate metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0004616 NADP binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG2653 6-phosphogluconate dehydrogenase Cluster-8309.39684 BP_3 865.29 11.29 3987 646717218 KDR20164.1 788 1.1e-80 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 1.26758e-57 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 2.5e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF00313 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.39685 BP_3 294.26 3.34 4537 646717218 KDR20164.1 788 1.2e-80 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 1.44403e-57 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 2.8e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00313//PF16367//PF00076 'Cold-shock' DNA-binding domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.39686 BP_3 158.24 3.69 2360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178//PF03286 AT hook motif//Pox virus Ag35 surface protein -- -- GO:0003677 DNA binding GO:0019031 viral envelope -- -- Cluster-8309.39687 BP_3 558.94 12.29 2483 642930832 XP_008196105.1 690 1.6e-69 PREDICTED: apoptosis-inducing factor 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96NN9 406 5.5e-38 Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1 PF00348//PF07992 Polyprenyl synthetase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0008299 oxidation-reduction process//isoprenoid biosynthetic process GO:0016491 oxidoreductase activity -- -- KOG1336 Monodehydroascorbate/ferredoxin reductase Cluster-8309.39688 BP_3 369.29 26.60 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39689 BP_3 66.00 4.39 1017 403311095 AFR34054.1 1206 9.4e-130 NADH dehydrogenase subunit 5 (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 1014 0 Scylla paramamosain mitochondrion, complete genome K03883 ND5 NADH-ubiquinone oxidoreductase chain 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03883 P07706 646 3.4e-66 NADH-ubiquinone oxidoreductase chain 5 OS=Drosophila yakuba GN=mt:ND5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-8309.3969 BP_3 31.00 0.54 3038 642935265 XP_008197939.1 481 3.3e-45 PREDICTED: LOW QUALITY PROTEIN: rho GTPase-activating protein 100F [Tribolium castaneum] 462323311 APGK01042524.1 75 2.79393e-28 Dendroctonus ponderosae Seq01042534, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39690 BP_3 950.81 9.43 5150 642939347 XP_970218.2 2431 4.3e-271 PREDICTED: lipase maturation factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKZ9 1010 1.1e-107 Lipase maturation factor 2 OS=Gallus gallus GN=LMF2 PE=2 SV=2 PF05175//PF03602//PF01741//PF10237 Methyltransferase small domain//Conserved hypothetical protein 95//Large-conductance mechanosensitive channel, MscL//Probable N6-adenine methyltransferase GO:0006810//GO:0031167//GO:0006811 transport//rRNA methylation//ion transport GO:0005216//GO:0008168 ion channel activity//methyltransferase activity GO:0016021 integral component of membrane KOG3350 Uncharacterized conserved protein Cluster-8309.39691 BP_3 70.86 0.68 5347 642939347 XP_970218.2 2290 1.0e-254 PREDICTED: lipase maturation factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKZ9 935 5.4e-99 Lipase maturation factor 2 OS=Gallus gallus GN=LMF2 PE=2 SV=2 PF05175//PF10237//PF03602 Methyltransferase small domain//Probable N6-adenine methyltransferase//Conserved hypothetical protein 95 GO:0031167 rRNA methylation GO:0008168 methyltransferase activity -- -- KOG3350 Uncharacterized conserved protein Cluster-8309.39692 BP_3 34.17 0.50 3581 642913885 XP_008201201.1 1316 5.9e-142 PREDICTED: forkhead box protein O isoform X2 [Tribolium castaneum] 642913884 XM_008202979.1 416 0 PREDICTED: Tribolium castaneum forkhead box protein O (LOC664090), transcript variant X2, mRNA K09408 FOXO3 forkhead box protein O3 http://www.genome.jp/dbget-bin/www_bget?ko:K09408 B3LYS5 667 4.3e-68 Forkhead box protein O OS=Drosophila ananassae GN=foxo PE=3 SV=2 PF01342//PF00250 SAND domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.39693 BP_3 114.49 1.75 3438 91076824 XP_967870.1 1208 1.9e-129 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 729 2.7e-75 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- KOG1212 Amidases Cluster-8309.39695 BP_3 309.02 4.03 3991 642922190 XP_008193053.1 1274 4.8e-137 PREDICTED: patronin isoform X1 [Tribolium castaneum] -- -- -- -- -- K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 285 9.6e-24 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39696 BP_3 175.35 1.70 5266 189235271 XP_973061.2 1362 4.0e-147 PREDICTED: MKL/myocardin-like protein 2 isoform X1 [Tribolium castaneum] 642916149 XM_967968.3 439 0 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X1, mRNA -- -- -- -- Q8K4J6 314 5.5e-27 MKL/myocardin-like protein 1 OS=Mus musculus GN=Mkl1 PE=1 SV=2 PF11744 Aluminium activated malate transporter GO:0015743 malate transport -- -- -- -- -- -- Cluster-8309.397 BP_3 18.00 0.59 1753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39700 BP_3 2988.99 13.86 10688 270014310 EFA10758.1 3865 0.0e+00 starry night [Tribolium castaneum] 332376259 BT128312.1 203 6.93826e-99 Dendroctonus ponderosae clone DPO105_N17 unknown mRNA K04600 CELSR1 cadherin EGF LAG seven-pass G-type receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04600 Q9V5N8 1132 1.6e-121 Protocadherin-like wing polarity protein stan OS=Drosophila melanogaster GN=stan PE=1 SV=4 PF00002//PF07732//PF02421//PF03348//PF00025//PF01926//PF08477//PF00071//PF04670//PF01825//PF02793//PF00837//PF03193 7 transmembrane receptor (Secretin family)//Multicopper oxidase//Ferrous iron transport protein B//Serine incorporator (Serinc)//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ras family//Gtr1/RagA G protein conserved region//GPCR proteolysis site, GPS, motif//Hormone receptor domain//Iodothyronine deiodinase//Protein of unknown function, DUF258 GO:0015684//GO:0007264//GO:0055114//GO:0007186 ferrous iron transport//small GTPase mediated signal transduction//oxidation-reduction process//G-protein coupled receptor signaling pathway GO:0005525//GO:0004800//GO:0003924//GO:0004930//GO:0005507//GO:0015093 GTP binding//thyroxine 5'-deiodinase activity//GTPase activity//G-protein coupled receptor activity//copper ion binding//ferrous iron transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0395 Ras-related GTPase Cluster-8309.39701 BP_3 49.92 0.33 7530 642919657 XP_008192010.1 2106 3.1e-233 PREDICTED: kinesin light chain isoform X2 [Tribolium castaneum]>gi|270005876|gb|EFA02324.1| hypothetical protein TcasGA2_TC007992 [Tribolium castaneum] 817205684 XM_012423337.1 302 4.51564e-154 PREDICTED: Orussus abietinus kinesin light chain (LOC105698786), transcript variant X2, mRNA K10407 KLC kinesin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10407 P46824 1557 5.7e-171 Kinesin light chain OS=Drosophila melanogaster GN=Klc PE=1 SV=1 PF13181//PF13174//PF00515//PF13374//PF03836//PF11365//PF13176//PF00637//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//RasGAP C-terminus//Protein of unknown function (DUF3166)//Tetratricopeptide repeat//Region in Clathrin and VPS//TPR repeat GO:0007017//GO:0007264//GO:0010506//GO:0006886//GO:0016192 microtubule-based process//small GTPase mediated signal transduction//regulation of autophagy//intracellular protein transport//vesicle-mediated transport GO:0005096//GO:0003777//GO:0005515 GTPase activator activity//microtubule motor activity//protein binding GO:0005615//GO:0005874//GO:0005871 extracellular space//microtubule//kinesin complex KOG1840 Kinesin light chain Cluster-8309.39702 BP_3 38.71 0.96 2231 642937160 XP_969386.2 560 1.7e-54 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] -- -- -- -- -- K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 Q1RMU3 379 6.7e-35 Prolyl 4-hydroxylase subunit alpha-1 OS=Bos taurus GN=P4HA1 PE=1 SV=1 PF08476//PF13640//PF03171 Viral D10 N-terminal//2OG-Fe(II) oxygenase superfamily//2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016791//GO:0016491 phosphatase activity//oxidoreductase activity -- -- KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.39703 BP_3 2770.17 19.44 7160 270001906 EEZ98353.1 273 1.0e-20 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39706 BP_3 53.10 0.78 3577 91083493 XP_976358.1 1712 7.1e-188 PREDICTED: uncharacterized protein LOC660773 [Tribolium castaneum]>gi|642928430|ref|XP_008193781.1| PREDICTED: uncharacterized protein LOC660773 [Tribolium castaneum]>gi|270010837|gb|EFA07285.1| hypothetical protein TcasGA2_TC014520 [Tribolium castaneum] -- -- -- -- -- K00586 DPH5 diphthine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00586 Q9H2P9 611 1.4e-61 Diphthine methyl ester synthase OS=Homo sapiens GN=DPH5 PE=1 SV=2 PF06743//PF00590 FAST kinase-like protein, subdomain 1//Tetrapyrrole (Corrin/Porphyrin) Methylases GO:0008152 metabolic process GO:0004672//GO:0008168 protein kinase activity//methyltransferase activity -- -- KOG3123 Diphthine synthase Cluster-8309.39707 BP_3 85.00 4.50 1202 557767939 XP_005183655.1 515 1.5e-49 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Musca domestica] 195569934 XM_002102928.1 182 3.58954e-88 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 P47815 390 1.9e-36 Eukaryotic translation initiation factor 1A OS=Triticum aestivum PE=1 SV=2 PF01176 Translation initiation factor 1A / IF-1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.39708 BP_3 33.06 0.85 2176 91079674 XP_967161.1 318 1.9e-26 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Tribolium castaneum]>gi|270004484|gb|EFA00932.1| hypothetical protein TcasGA2_TC003838 [Tribolium castaneum] 195569934 XM_002102928.1 122 1.48731e-54 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 Q8BMJ3 289 1.8e-24 Eukaryotic translation initiation factor 1A, X-chromosomal OS=Mus musculus GN=Eif1ax PE=2 SV=3 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.39709 BP_3 7.98 0.38 1309 557767939 XP_005183655.1 515 1.6e-49 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Musca domestica] 195569934 XM_002102928.1 184 3.02931e-89 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 P47815 390 2.1e-36 Eukaryotic translation initiation factor 1A OS=Triticum aestivum PE=1 SV=2 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.39710 BP_3 997.02 64.39 1038 642916084 XP_008190883.1 1477 3.6e-161 PREDICTED: ribose-phosphate pyrophosphokinase 1 isoform X1 [Tribolium castaneum]>gi|270003720|gb|EFA00168.1| hypothetical protein TcasGA2_TC002990 [Tribolium castaneum] 837814424 XM_012928152.1 234 3.82999e-117 PREDICTED: Ochotona princeps ribose-phosphate pyrophosphokinase 1 (LOC101518950), mRNA K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 P60892 1264 7.5e-138 Ribose-phosphate pyrophosphokinase 1 OS=Rattus norvegicus GN=Prps1 PE=1 SV=2 PF00156//PF14572 Phosphoribosyl transferase domain//Phosphoribosyl synthetase-associated domain GO:0009116//GO:0006098//GO:0016310//GO:0009165//GO:0009156//GO:0006144 nucleoside metabolic process//pentose-phosphate shunt//phosphorylation//nucleotide biosynthetic process//ribonucleoside monophosphate biosynthetic process//purine nucleobase metabolic process GO:0016301//GO:0000287//GO:0004749 kinase activity//magnesium ion binding//ribose phosphate diphosphokinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.39711 BP_3 31.91 0.53 3187 546673138 ERL84803.1 2449 2.2e-273 hypothetical protein D910_02228 [Dendroctonus ponderosae] 297804109 XM_002869893.1 59 2.29934e-19 Arabidopsis lyrata subsp. lyrata CTP synthase, mRNA K01937 pyrG, CTPS CTP synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01937 Q2M197 1861 1.4e-206 CTP synthase OS=Drosophila pseudoobscura pseudoobscura GN=CTPsyn PE=3 SV=2 PF00834//PF06418//PF07722 Ribulose-phosphate 3 epimerase family//CTP synthase N-terminus//Peptidase C26 GO:0006221//GO:0006206//GO:0006541//GO:0005975 pyrimidine nucleotide biosynthetic process//pyrimidine nucleobase metabolic process//glutamine metabolic process//carbohydrate metabolic process GO:0016857//GO:0016787//GO:0003883 racemase and epimerase activity, acting on carbohydrates and derivatives//hydrolase activity//CTP synthase activity -- -- KOG2387 CTP synthase (UTP-ammonia lyase) Cluster-8309.39713 BP_3 741.93 3.72 9909 642935463 XP_008198020.1 3170 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X1 [Tribolium castaneum] 642935470 XM_967302.3 113 6.90223e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- Q6A0A9 763 8.9e-79 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 PF00083//PF01328//PF07690 Sugar (and other) transporter//Peroxidase, family 2//Major Facilitator Superfamily GO:0006804//GO:0006979//GO:0055085 obsolete peroxidase reaction//response to oxidative stress//transmembrane transport GO:0022857//GO:0004601 transmembrane transporter activity//peroxidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.39715 BP_3 45.96 0.68 3546 642925776 XP_008201712.1 2274 4.8e-253 PREDICTED: solute carrier family 26 member 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 8.9e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.39716 BP_3 73.59 1.04 3688 91084681 XP_968452.1 2285 2.6e-254 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925779|ref|XP_008201721.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925781|ref|XP_008201727.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925783|ref|XP_008190266.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|270008928|gb|EFA05376.1| hypothetical protein TcasGA2_TC015542 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 9.2e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0044765//GO:0008272 single-organism transport//sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.39717 BP_3 170.00 7.73 1352 566080617 AHC54390.1 1507 1.6e-164 adenine nucleotide translocase 2 [Scylla paramamosain] 566080616 KF709943.1 1333 0 Scylla paramamosain adenine nucleotide translocase 2 (ANT2) mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q26365 1244 2.0e-135 ADP,ATP carrier protein OS=Drosophila melanogaster GN=sesB PE=2 SV=4 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.39718 BP_3 1317.80 22.55 3108 642932516 XP_008197146.1 3187 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B isoform X2 [Tribolium castaneum] 642932515 XM_008198924.1 721 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X3, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03043 2658 5.1e-299 cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster GN=for PE=1 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.39719 BP_3 2120.30 19.57 5515 167234451 NP_001107840.1 4552 0.0e+00 Dicer-2 [Tribolium castaneum]>gi|642913971|ref|XP_008201496.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|642913973|ref|XP_008201497.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|270002830|gb|EEZ99277.1| hypothetical protein TcasGA2_TC001108 [Tribolium castaneum] 642913972 XM_008203275.1 50 4.02651e-14 PREDICTED: Tribolium castaneum Dicer-2 (Dcr-2), transcript variant X2, mRNA -- -- -- -- P34529 1074 4.3e-115 Endoribonuclease dcr-1 OS=Caenorhabditis elegans GN=dcr-1 PE=1 SV=3 PF00270//PF03368//PF02170//PF04851//PF14622//PF00636 DEAD/DEAH box helicase//Dicer dimerisation domain//PAZ domain//Type III restriction enzyme, res subunit//Ribonuclease-III-like//Ribonuclease III domain GO:0016072//GO:0006396//GO:0034470//GO:0051252 rRNA metabolic process//RNA processing//ncRNA processing//regulation of RNA metabolic process GO:0003676//GO:0016891//GO:0043167//GO:0004525//GO:0016787//GO:0003677//GO:0005524//GO:0003723//GO:0004386//GO:0005515 nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters//ion binding//ribonuclease III activity//hydrolase activity//DNA binding//ATP binding//RNA binding//helicase activity//protein binding -- -- KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.39720 BP_3 166.38 1.49 5659 546683632 ERL93420.1 2078 4.1e-230 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 Q9PTP2 475 1.3e-45 Axin-related protein OS=Xenopus laevis PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39722 BP_3 1045.74 54.95 1209 642934971 XP_008196003.1 515 1.5e-49 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 48 1.11642e-13 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39723 BP_3 50.01 2.03 1477 399240763 AFP43193.1 288 3.9e-23 Bv80, partial [Babesia bovis]>gi|399240779|gb|AFP43201.1| Bv80, partial [Babesia bovis] -- -- -- -- -- -- -- -- -- O77788 192 2.2e-13 Neurofilament medium polypeptide OS=Bos taurus GN=NEFM PE=1 SV=3 PF01158//PF05748 Ribosomal protein L36e//Rubella membrane glycoprotein E1 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0019013//GO:0005622//GO:0016021//GO:0005840 viral nucleocapsid//intracellular//integral component of membrane//ribosome -- -- Cluster-8309.39725 BP_3 6202.82 47.73 6555 826459786 XP_012533972.1 4760 0.0e+00 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X1 [Monomorium pharaonis] 407731599 JQ771517.1 1604 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4682 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00122//PF08686//PF00095//PF00499//PF13895//PF05790//PF04545//PF01545 E1-E2 ATPase//PLAC (protease and lacunin) domain//WAP-type (Whey Acidic Protein) 'four-disulfide core'//NADH-ubiquinone/plastoquinone oxidoreductase chain 6//Immunoglobulin domain//Immunoglobulin C2-set domain//Sigma-70, region 4//Cation efflux family GO:0015992//GO:0055114//GO:0006355//GO:0006812//GO:0006814//GO:0006120//GO:0055085//GO:0006352//GO:0006744//GO:0007155 proton transport//oxidation-reduction process//regulation of transcription, DNA-templated//cation transport//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//transmembrane transport//DNA-templated transcription, initiation//ubiquinone biosynthetic process//cell adhesion GO:0008137//GO:0003700//GO:0030414//GO:0008233//GO:0000166//GO:0008324//GO:0046872//GO:0016987//GO:0005515//GO:0003677 NADH dehydrogenase (ubiquinone) activity//transcription factor activity, sequence-specific DNA binding//peptidase inhibitor activity//peptidase activity//nucleotide binding//cation transmembrane transporter activity//metal ion binding//sigma factor activity//protein binding//DNA binding GO:0016021//GO:0005576//GO:0005667 integral component of membrane//extracellular region//transcription factor complex KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.39726 BP_3 2138.24 6.15 17038 826459797 XP_012533974.1 4761 0.0e+00 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X3 [Monomorium pharaonis] 407731599 JQ771517.1 1604 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00122//PF08686//PF00095//PF05986//PF13895//PF04545//PF00014//PF02714 E1-E2 ATPase//PLAC (protease and lacunin) domain//WAP-type (Whey Acidic Protein) 'four-disulfide core'//ADAM-TS Spacer 1//Immunoglobulin domain//Sigma-70, region 4//Kunitz/Bovine pancreatic trypsin inhibitor domain//Calcium-dependent channel, 7TM region, putative phosphate GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003677//GO:0004867//GO:0005515//GO:0016987//GO:0046872//GO:0004222//GO:0000166//GO:0003700//GO:0030414//GO:0008233 DNA binding//serine-type endopeptidase inhibitor activity//protein binding//sigma factor activity//metal ion binding//metalloendopeptidase activity//nucleotide binding//transcription factor activity, sequence-specific DNA binding//peptidase inhibitor activity//peptidase activity GO:0031012//GO:0005667//GO:0005576//GO:0016020 extracellular matrix//transcription factor complex//extracellular region//membrane KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.39728 BP_3 27.75 0.53 2806 242015216 XP_002428268.1 1387 2.7e-150 cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis]>gi|212512842|gb|EEB15530.1| cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis] 558203653 XM_006132037.1 59 2.02132e-19 PREDICTED: Pelodiscus sinensis mitogen-activated protein kinase kinase 7 (MAP2K7), partial mRNA K04432 MAP2K3, MKK3 mitogen-activated protein kinase kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04432 O09110 1133 3.1e-122 Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus GN=Map2k3 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 Cluster-8309.39729 BP_3 92.65 0.42 10907 91088841 XP_970807.1 2162 1.4e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.92955e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 6.3e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF00538//PF01853//PF00628//PF01160//PF06431//PF13508 linker histone H1 and H5 family//MOZ/SAS family//PHD-finger//Vertebrate endogenous opioids neuropeptide//Polyomavirus large T antigen C-terminus//Acetyltransferase (GNAT) domain GO:0007218//GO:0006260//GO:0006355//GO:0006334//GO:0042967 neuropeptide signaling pathway//DNA replication//regulation of transcription, DNA-templated//nucleosome assembly//acyl-carrier-protein biosynthetic process GO:0005488//GO:0016747//GO:0003677//GO:0005524//GO:0005515//GO:0008080 binding//transferase activity, transferring acyl groups other than amino-acyl groups//DNA binding//ATP binding//protein binding//N-acetyltransferase activity GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.39731 BP_3 396.86 1.69 11612 642936312 XP_008198391.1 6744 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 1.00338e-77 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3329 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF00018//PF14604//PF07651//PF01608//PF03822 SH3 domain//Variant SH3 domain//ANTH domain//I/LWEQ domain//NAF domain GO:0007165 signal transduction GO:0005543//GO:0003779//GO:0005515 phospholipid binding//actin binding//protein binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.39732 BP_3 310.45 1.36 11307 642936312 XP_008198391.1 8147 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 9.76939e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3605 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF14604//PF00018//PF07651//PF01608//PF03822 Variant SH3 domain//SH3 domain//ANTH domain//I/LWEQ domain//NAF domain GO:0007165 signal transduction GO:0003779//GO:0005515//GO:0005543 actin binding//protein binding//phospholipid binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.39733 BP_3 36.50 0.60 3214 642939027 XP_008200193.1 2676 1.0e-299 PREDICTED: puromycin-sensitive aminopeptidase-like protein [Tribolium castaneum] 195336597 XM_002034886.1 288 1.16121e-146 Drosophila sechellia GM14417 (Dsec\GM14417), mRNA K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 P55786 1995 4.0e-222 Puromycin-sensitive aminopeptidase OS=Homo sapiens GN=NPEPPS PE=1 SV=2 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.39734 BP_3 2016.25 39.65 2743 642939027 XP_008200193.1 3110 0.0e+00 PREDICTED: puromycin-sensitive aminopeptidase-like protein [Tribolium castaneum] 195336597 XM_002034886.1 293 1.64346e-149 Drosophila sechellia GM14417 (Dsec\GM14417), mRNA K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 P55786 2207 8.9e-247 Puromycin-sensitive aminopeptidase OS=Homo sapiens GN=NPEPPS PE=1 SV=2 PF03814//PF01433 Potassium-transporting ATPase A subunit//Peptidase family M1 GO:0006813 potassium ion transport GO:0008556//GO:0008270//GO:0008237 potassium-transporting ATPase activity//zinc ion binding//metallopeptidase activity GO:0005886 plasma membrane KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.39736 BP_3 610.42 5.59 5554 91094499 XP_971436.1 1171 5.9e-125 PREDICTED: phosphopantothenate--cysteine ligase [Tribolium castaneum]>gi|270000749|gb|EEZ97196.1| hypothetical protein TcasGA2_TC004384 [Tribolium castaneum] -- -- -- -- -- K01922 PPCS, coaB phosphopantothenate-cysteine ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01922 Q9HAB8 579 1.1e-57 Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2728 Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase Cluster-8309.39737 BP_3 447.58 4.39 5207 91084043 XP_967085.1 2172 4.7e-241 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 239 3.27553e-119 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1834 3.0e-203 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF10415//PF00491 Fumarase C C-terminus//Arginase family GO:0019643//GO:0006106//GO:0006099 reductive tricarboxylic acid cycle//fumarate metabolic process//tricarboxylic acid cycle GO:0004333//GO:0016829//GO:0046872 fumarate hydratase activity//lyase activity//metal ion binding GO:0045239 tricarboxylic acid cycle enzyme complex KOG1317 Fumarase Cluster-8309.39739 BP_3 2381.35 23.85 5105 91084043 XP_967085.1 2172 4.6e-241 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 239 3.21092e-119 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1834 3.0e-203 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF10415//PF00491//PF01607 Fumarase C C-terminus//Arginase family//Chitin binding Peritrophin-A domain GO:0006106//GO:0006099//GO:0019643//GO:0006030 fumarate metabolic process//tricarboxylic acid cycle//reductive tricarboxylic acid cycle//chitin metabolic process GO:0008061//GO:0004333//GO:0016829//GO:0046872 chitin binding//fumarate hydratase activity//lyase activity//metal ion binding GO:0045239//GO:0005576 tricarboxylic acid cycle enzyme complex//extracellular region KOG1317 Fumarase Cluster-8309.39740 BP_3 370.85 4.20 4551 642934408 XP_008197648.1 1959 2.1e-216 PREDICTED: transport and Golgi organization protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VMA7 461 4.3e-44 Transport and Golgi organization protein 1 OS=Drosophila melanogaster GN=Tango1 PE=1 SV=2 PF05791//PF00734//PF00038 Bacillus haemolytic enterotoxin (HBL)//Fungal cellulose binding domain//Intermediate filament protein GO:0009405//GO:0005975 pathogenesis//carbohydrate metabolic process GO:0004553//GO:0030248//GO:0005198 hydrolase activity, hydrolyzing O-glycosyl compounds//cellulose binding//structural molecule activity GO:0005882//GO:0016020//GO:0005576 intermediate filament//membrane//extracellular region -- -- Cluster-8309.39742 BP_3 1167.03 6.75 8624 270012222 EFA08670.1 2246 2.0e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTX9 413 3.0e-38 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF06974//PF03007//PF07690//PF01277 Protein of unknown function (DUF1298)//Wax ester synthase-like Acyl-CoA acyltransferase domain//Major Facilitator Superfamily//Oleosin GO:0046486//GO:0042967//GO:0045017//GO:0055085 glycerolipid metabolic process//acyl-carrier-protein biosynthetic process//glycerolipid biosynthetic process//transmembrane transport GO:0004144 diacylglycerol O-acyltransferase activity GO:0016021//GO:0012511 integral component of membrane//monolayer-surrounded lipid storage body KOG2504 Monocarboxylate transporter Cluster-8309.39745 BP_3 422.73 3.97 5424 270011060 EFA07508.1 3837 0.0e+00 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20742 1226 1.0e-132 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 PF01483//PF00207//PF07678//PF07677//PF01835 Proprotein convertase P-domain//Alpha-2-macroglobulin family//A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain GO:0006508 proteolysis GO:0004866//GO:0004252 endopeptidase inhibitor activity//serine-type endopeptidase activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.39747 BP_3 6.15 0.82 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39748 BP_3 2519.29 32.43 4036 642933107 XP_008197261.1 1670 5.9e-183 PREDICTED: prominin-like protein isoform X1 [Tribolium castaneum]>gi|270011437|gb|EFA07885.1| hypothetical protein TcasGA2_TC005459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 530 3.8e-52 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF07926//PF02417//PF07464//PF13903//PF04513//PF01442//PF05478//PF05356 TPR/MLP1/MLP2-like protein//Chromate transporter//Apolipophorin-III precursor (apoLp-III)//PMP-22/EMP/MP20/Claudin tight junction//Baculovirus polyhedron envelope protein, PEP, C terminus//Apolipoprotein A1/A4/E domain//Prominin//Phage Coat protein B GO:0006606//GO:0015703//GO:0042157//GO:0006869 protein import into nucleus//chromate transport//lipoprotein metabolic process//lipid transport GO:0015109//GO:0008289//GO:0005198 chromate transmembrane transporter activity//lipid binding//structural molecule activity GO:0005576//GO:0019028//GO:0016021//GO:0019031 extracellular region//viral capsid//integral component of membrane//viral envelope KOG4331 Polytopic membrane protein Prominin Cluster-8309.39749 BP_3 129.99 6.73 1223 91081289 XP_968282.1 617 2.3e-61 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270006089|gb|EFA02537.1| hypothetical protein TcasGA2_TC008242 [Tribolium castaneum] -- -- -- -- -- K06537 CD151, TSPAN24 CD151 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06537 O35566 442 1.8e-42 CD151 antigen OS=Mus musculus GN=Cd151 PE=2 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.39750 BP_3 2048.77 48.35 2334 91080723 XP_975387.1 1549 3.7e-169 PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919596|ref|XP_008191933.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919599|ref|XP_008191934.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|270005868|gb|EFA02316.1| hypothetical protein TcasGA2_TC007982 [Tribolium castaneum] -- -- -- -- -- K16779 RAB3IP, RABIN8 Rab-3A-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K16779 Q2KJ58 583 1.6e-58 Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus GN=RAB3IL1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39751 BP_3 39.16 0.80 2648 91087475 XP_967673.1 2015 3.8e-223 PREDICTED: 26S protease regulatory subunit 6A-B [Tribolium castaneum]>gi|270010662|gb|EFA07110.1| hypothetical protein TcasGA2_TC010100 [Tribolium castaneum] 54287935 AY750868.1 407 0 Toxoptera citricida putative 26S protease regulatory subunit 6A mRNA, complete cds K03065 PSMC3, RPT5 26S proteasome regulatory subunit T5 http://www.genome.jp/dbget-bin/www_bget?ko:K03065 O88685 1805 3.5e-200 26S protease regulatory subunit 6A OS=Mus musculus GN=Psmc3 PE=1 SV=2 PF00910//PF00005//PF02562//PF00004//PF07724//PF01695//PF07728//PF05496//PF00158 RNA helicase//ABC transporter//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain GO:0006281//GO:0006355//GO:0006310//GO:0030163 DNA repair//regulation of transcription, DNA-templated//DNA recombination//protein catabolic process GO:0005524//GO:0003723//GO:0008134//GO:0016887//GO:0009378//GO:0017111//GO:0003724 ATP binding//RNA binding//transcription factor binding//ATPase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity GO:0009379//GO:0005657//GO:0005667//GO:0005737 Holliday junction helicase complex//replication fork//transcription factor complex//cytoplasm KOG0652 26S proteasome regulatory complex, ATPase RPT5 Cluster-8309.39753 BP_3 132.08 48.93 421 91092422 XP_968009.1 638 2.9e-64 PREDICTED: ATP-binding cassette sub-family E member 1 [Tribolium castaneum]>gi|642917265|ref|XP_008199227.1| PREDICTED: ATP-binding cassette sub-family E member 1 [Tribolium castaneum]>gi|270004744|gb|EFA01192.1| hypothetical protein TcasGA2_TC010519 [Tribolium castaneum] -- -- -- -- -- K06174 ABCE1 ATP-binding cassette, sub-family E, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06174 P61221 543 1.2e-54 ATP-binding cassette sub-family E member 1 OS=Homo sapiens GN=ABCE1 PE=1 SV=1 PF00005//PF13304 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006200//GO:0006118 obsolete ATP catabolic process//obsolete electron transport GO:0009055//GO:0051536//GO:0005524//GO:0016887 electron carrier activity//iron-sulfur cluster binding//ATP binding//ATPase activity -- -- KOG0063 RNAse L inhibitor, ABC superfamily Cluster-8309.39754 BP_3 14.35 0.79 1168 91079574 XP_966886.1 841 2.3e-87 PREDICTED: ubiquitin carboxyl-terminal hydrolase [Tribolium castaneum]>gi|270004456|gb|EFA00904.1| hypothetical protein TcasGA2_TC003809 [Tribolium castaneum] -- -- -- -- -- K05609 UCHL3, YUH1 ubiquitin carboxyl-terminal hydrolase L3 http://www.genome.jp/dbget-bin/www_bget?ko:K05609 P35122 548 8.9e-55 Ubiquitin carboxyl-terminal hydrolase OS=Drosophila melanogaster GN=Uch PE=2 SV=2 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006511//GO:0006508//GO:0016579 ubiquitin-dependent protein catabolic process//proteolysis//protein deubiquitination GO:0004221//GO:0004843 obsolete ubiquitin thiolesterase activity//ubiquitin-specific protease activity GO:0005622 intracellular KOG1415 Ubiquitin C-terminal hydrolase UCHL1 Cluster-8309.39756 BP_3 443.00 14.24 1791 642934668 XP_008197760.1 2040 3.3e-226 PREDICTED: nuclear receptor-binding protein homolog [Tribolium castaneum] 642934667 XM_008199538.1 588 0 PREDICTED: Tribolium castaneum nuclear receptor-binding protein homolog (LOC661173), mRNA K08875 NRBP nuclear receptor-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08875 Q9Y0Y6 1362 5.6e-149 Nuclear receptor-binding protein homolog OS=Drosophila melanogaster GN=Madm PE=1 SV=1 PF01365//PF07714//PF00069 RIH domain//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0070588//GO:0006816 protein phosphorylation//calcium ion transmembrane transport//calcium ion transport GO:0004672//GO:0005262//GO:0005524 protein kinase activity//calcium channel activity//ATP binding GO:0016020 membrane KOG1266 Protein kinase Cluster-8309.39757 BP_3 2094.08 14.65 7180 642918063 XP_008193852.1 6447 0.0e+00 PREDICTED: nucleoprotein TPR isoform X3 [Tribolium castaneum] -- -- -- -- -- K09291 TPR, MLP1, MLP2 nucleoprotein TPR http://www.genome.jp/dbget-bin/www_bget?ko:K09291 A1Z8P9 2086 2.5e-232 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07926//PF02186//PF05294//PF06005//PF07544 TPR/MLP1/MLP2-like protein//TFIIE beta subunit core domain//Scorpion short toxin//Protein of unknown function (DUF904)//RNA polymerase II transcription mediator complex subunit 9 GO:0009405//GO:0043093//GO:0000917//GO:0006367//GO:0006357//GO:0006606 pathogenesis//FtsZ-dependent cytokinesis//barrier septum assembly//transcription initiation from RNA polymerase II promoter//regulation of transcription from RNA polymerase II promoter//protein import into nucleus GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005737//GO:0005576 mediator complex//cytoplasm//extracellular region KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.39758 BP_3 4805.41 32.01 7528 642918059 XP_008193846.1 6819 0.0e+00 PREDICTED: nucleoprotein TPR isoform X1 [Tribolium castaneum] -- -- -- -- -- K09291 TPR, MLP1, MLP2 nucleoprotein TPR http://www.genome.jp/dbget-bin/www_bget?ko:K09291 A1Z8P9 2086 2.6e-232 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07926//PF02186//PF06005//PF05294//PF07544 TPR/MLP1/MLP2-like protein//TFIIE beta subunit core domain//Protein of unknown function (DUF904)//Scorpion short toxin//RNA polymerase II transcription mediator complex subunit 9 GO:0009405//GO:0006367//GO:0043093//GO:0000917//GO:0006357//GO:0006606 pathogenesis//transcription initiation from RNA polymerase II promoter//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of transcription from RNA polymerase II promoter//protein import into nucleus GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005737//GO:0005576 mediator complex//cytoplasm//extracellular region KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.39760 BP_3 1438.30 11.62 6257 157111277 XP_001651466.1 5403 0.0e+00 AAEL005801-PA [Aedes aegypti]>gi|108878460|gb|EAT42685.1| AAEL005801-PA [Aedes aegypti] 170063636 XM_001867153.1 194 4.08059e-94 Culex quinquefasciatus bifunctional aminoacyl-tRNA synthetase, mRNA K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 P28668 5247 0.0e+00 Bifunctional glutamate/proline--tRNA ligase OS=Drosophila melanogaster GN=Aats-glupro PE=1 SV=2 PF03950//PF00749//PF00587//PF00992//PF00458//PF09180//PF02146 tRNA synthetases class I (E and Q), anti-codon binding domain//tRNA synthetases class I (E and Q), catalytic domain//tRNA synthetase class II core domain (G, H, P, S and T)//Troponin//WHEP-TRS domain//Prolyl-tRNA synthetase, C-terminal//Sir2 family GO:0006525//GO:0006560//GO:0006418//GO:0006433//GO:0043039 arginine metabolic process//proline metabolic process//tRNA aminoacylation for protein translation//prolyl-tRNA aminoacylation//tRNA aminoacylation GO:0005524//GO:0070403//GO:0000166//GO:0004827//GO:0016876//GO:0004812 ATP binding//NAD+ binding//nucleotide binding//proline-tRNA ligase activity//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity GO:0005737//GO:0005861 cytoplasm//troponin complex KOG4163 Prolyl-tRNA synthetase Cluster-8309.39761 BP_3 134.00 3.15 2342 546678697 ERL89265.1 1371 1.6e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 2.9e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.39763 BP_3 19.65 0.38 2804 478254653 ENN74894.1 497 4.3e-47 hypothetical protein YQE_08473, partial [Dendroctonus ponderosae]>gi|546676113|gb|ERL87180.1| hypothetical protein D910_04580 [Dendroctonus ponderosae] -- -- -- -- -- K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 Q2EF73 447 1.1e-42 SUMO-conjugating enzyme UBC9 OS=Spermophilus tridecemlineatus GN=UBE2I PE=1 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.39764 BP_3 33.21 0.38 4512 642921287 XP_008192801.1 4438 0.0e+00 PREDICTED: disheveled-associated activator of morphogenesis 1 isoform X1 [Tribolium castaneum] 642921292 XM_008194582.1 488 0 PREDICTED: Tribolium castaneum disheveled-associated activator of morphogenesis 1 (LOC658864), transcript variant X4, mRNA K04512 DAAM dishevelled associated activator of morphogenesis http://www.genome.jp/dbget-bin/www_bget?ko:K04512 Q8BPM0 1369 2.2e-149 Disheveled-associated activator of morphogenesis 1 OS=Mus musculus GN=Daam1 PE=1 SV=4 PF04561//PF01763//PF06367//PF06371 RNA polymerase Rpb2, domain 2//Herpesvirus UL6 like//Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0006351//GO:0016043//GO:0006144//GO:0006206//GO:0030036//GO:0006323 transcription, DNA-templated//cellular component organization//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//actin cytoskeleton organization//DNA packaging GO:0003677//GO:0003899//GO:0003779//GO:0017048 DNA binding//DNA-directed RNA polymerase activity//actin binding//Rho GTPase binding GO:0005730 nucleolus KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.39768 BP_3 1467.99 9.39 7829 91093216 XP_966931.1 11969 0.0e+00 PREDICTED: pre-mRNA-processing-splicing factor 8 [Tribolium castaneum]>gi|270016589|gb|EFA13035.1| hypothetical protein TcasGA2_TC010565 [Tribolium castaneum] 642938178 XM_961838.2 2578 0 PREDICTED: Tribolium castaneum pre-mRNA-processing-splicing factor 8 (LOC655310), mRNA K12856 PRPF8, PRP8 pre-mRNA-processing factor 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12856 Q6P2Q9 11264 0.0e+00 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens GN=PRPF8 PE=1 SV=2 PF08082//PF01398//PF08083//PF10596//PF10597//PF10598 PRO8NT (NUC069), PrP8 N-terminal domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//PROCN (NUC071) domain//U6-snRNA interacting domain of PrP8//U5-snRNA binding site 2 of PrP8//RNA recognition motif of the spliceosomal PrP8 GO:0000398 mRNA splicing, via spliceosome GO:0030623//GO:0005515//GO:0017070//GO:0003723 U5 snRNA binding//protein binding//U6 snRNA binding//RNA binding GO:0005681 spliceosomal complex KOG1795 U5 snRNP spliceosome subunit Cluster-8309.39769 BP_3 27.79 0.65 2363 91090912 XP_973979.1 279 6.8e-22 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] 642936036 XM_968886.2 90 9.94191e-37 PREDICTED: Tribolium castaneum troponin C, isoform 2 (LOC662809), mRNA -- -- -- -- P47949 252 3.8e-20 Troponin C, isoform 3 OS=Drosophila melanogaster GN=TpnC73F PE=2 SV=2 PF13405//PF00036//PF13499 EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.39770 BP_3 1922.00 75.42 1520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39776 BP_3 228.47 2.88 4114 642932847 XP_008197010.1 1563 1.5e-170 PREDICTED: NAD kinase-like isoform X2 [Tribolium castaneum] 751793735 XM_011208255.1 75 3.79535e-28 PREDICTED: Bactrocera dorsalis NAD kinase (LOC105228428), transcript variant X3, mRNA K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 P58058 1046 5.6e-112 NAD kinase OS=Mus musculus GN=Nadk PE=1 SV=2 PF00781//PF01513 Diacylglycerol kinase catalytic domain//ATP-NAD kinase GO:0006741//GO:0008152//GO:0046497//GO:0006769 NADP biosynthetic process//metabolic process//nicotinate nucleotide metabolic process//nicotinamide metabolic process GO:0016301//GO:0003951 kinase activity//NAD+ kinase activity -- -- KOG2178 Predicted sugar kinase Cluster-8309.39777 BP_3 8.00 0.86 739 290909031 ADD70030.1 525 6.4e-51 minus-C odorant binding protein 1 [Batocera horsfieldi] 290909030 GU575294.1 294 1.19079e-150 Batocera horsfieldi minus-C odorant binding protein 1 mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.39778 BP_3 769.78 6.00 6471 642918222 XP_008191418.1 7103 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 1 isoform X1 [Tribolium castaneum]>gi|270003291|gb|EEZ99738.1| hypothetical protein TcasGA2_TC002507 [Tribolium castaneum] 795022714 XM_012005302.1 605 0 PREDICTED: Vollenhovia emeryi transcription initiation factor TFIID subunit 1 (LOC105557903), mRNA K03125 TAF1 transcription initiation factor TFIID subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03125 Q8IZX4 3987 0.0e+00 Transcription initiation factor TFIID subunit 1-like OS=Homo sapiens GN=TAF1L PE=1 SV=1 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG0008 Transcription initiation factor TFIID, subunit TAF1 Cluster-8309.39779 BP_3 1987.43 15.30 6554 270002717 EEZ99164.1 9779 0.0e+00 hypothetical protein TcasGA2_TC016163 [Tribolium castaneum] 642912219 XM_965461.2 1827 0 PREDICTED: Tribolium castaneum putative U5 small nuclear ribonucleoprotein 200 kDa helicase (LOC659129), mRNA K12854 SNRNP200, BRR2 pre-mRNA-splicing helicase BRR2 http://www.genome.jp/dbget-bin/www_bget?ko:K12854 Q9VUV9 8701 0.0e+00 Putative U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Drosophila melanogaster GN=l(3)72Ab PE=2 SV=4 PF00437//PF01695//PF03412//PF03146//PF00270//PF00580//PF02562//PF04851 Type II/IV secretion system protein//IstB-like ATP binding protein//Peptidase C39 family//Agrin NtA domain//DEAD/DEAH box helicase//UvrD/REP helicase N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit GO:0043113//GO:0006508//GO:0007213//GO:0006810 receptor clustering//proteolysis//G-protein coupled acetylcholine receptor signaling pathway//transport GO:0003676//GO:0008233//GO:0005524//GO:0016787//GO:0003677//GO:0043236 nucleic acid binding//peptidase activity//ATP binding//hydrolase activity//DNA binding//laminin binding GO:0016021 integral component of membrane KOG0951 RNA helicase BRR2, DEAD-box superfamily Cluster-8309.3978 BP_3 25.00 0.79 1818 642913372 XP_008195444.1 1031 3.3e-109 PREDICTED: protein SHQ1 homolog [Tribolium castaneum]>gi|270001737|gb|EEZ98184.1| hypothetical protein TcasGA2_TC000613 [Tribolium castaneum] -- -- -- -- -- K14764 SHQ1 protein SHQ1 http://www.genome.jp/dbget-bin/www_bget?ko:K14764 Q3MHH1 531 1.3e-52 Protein SHQ1 homolog OS=Bos taurus GN=SHQ1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3247 Uncharacterized conserved protein Cluster-8309.39781 BP_3 52.00 4.39 863 642914186 XP_008201580.1 216 5.0e-15 PREDICTED: uncharacterized protein LOC661670 isoform X1 [Tribolium castaneum]>gi|270002176|gb|EEZ98623.1| hypothetical protein TcasGA2_TC001146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03802 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase GO:0051191 prosthetic group biosynthetic process -- -- -- -- -- -- Cluster-8309.39782 BP_3 331.98 7.17 2524 859132804 AKO63317.1 1918 6.5e-212 3-hydroxy-3-methylglutaryl coenzyme A synthase [Leptinotarsa decemlineata] -- -- -- -- -- K01641 E2.3.3.10 hydroxymethylglutaryl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01641 P54961 1642 2.7e-181 Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella germanica GN=HMGCS-1 PE=2 SV=1 PF01154//PF08540 Hydroxymethylglutaryl-coenzyme A synthase N terminal//Hydroxymethylglutaryl-coenzyme A synthase C terminal GO:0006552//GO:0008299//GO:0046950//GO:0006084//GO:0006574//GO:0006550 leucine catabolic process//isoprenoid biosynthetic process//cellular ketone body metabolic process//acetyl-CoA metabolic process//valine catabolic process//isoleucine catabolic process GO:0004421 hydroxymethylglutaryl-CoA synthase activity -- -- KOG1393 Hydroxymethylglutaryl-CoA synthase Cluster-8309.39783 BP_3 101.03 1.07 4833 642923742 XP_966686.2 2852 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X9 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O95573 1652 3.6e-182 Long-chain-fatty-acid--CoA ligase 3 OS=Homo sapiens GN=ACSL3 PE=1 SV=3 PF00501//PF00908 AMP-binding enzyme//dTDP-4-dehydrorhamnose 3,5-epimerase GO:0030639//GO:0008152//GO:0019872//GO:0009117 polyketide biosynthetic process//metabolic process//streptomycin biosynthetic process//nucleotide metabolic process GO:0008830//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//catalytic activity -- -- KOG1180 Acyl-CoA synthetase Cluster-8309.39787 BP_3 1001.77 8.96 5680 642939895 XP_008200229.1 2663 6.0e-298 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] 657546453 XM_008280188.1 50 4.14777e-14 PREDICTED: Stegastes partitus protein tyrosine phosphatase, non-receptor type 6 (ptpn6), mRNA K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q06124 1888 1.8e-209 Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens GN=PTPN11 PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes Cluster-8309.39788 BP_3 554.77 3.83 7277 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 5.06201e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 1.7e-26 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF13855//PF13895//PF00560//PF03526 Leucine rich repeat//Immunoglobulin domain//Leucine Rich Repeat//Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643//GO:0005515 toxic substance binding//protein binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.39790 BP_3 436.61 6.26 3654 478255919 ENN76121.1 2740 4.5e-307 hypothetical protein YQE_07341, partial [Dendroctonus ponderosae]>gi|546676534|gb|ERL87528.1| hypothetical protein D910_04919 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39792 BP_3 3006.09 20.75 7276 642935187 XP_008199684.1 1340 2.0e-144 PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|642935189|ref|XP_008199685.1| PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|270014202|gb|EFA10650.1| hypothetical protein TcasGA2_TC016287 [Tribolium castaneum] 558226116 XM_006137153.1 62 1.13503e-20 PREDICTED: Pelodiscus sinensis tetratricopeptide repeat domain 1 (TTC1), transcript variant X3, mRNA K12386 CTNS cystinosin http://www.genome.jp/dbget-bin/www_bget?ko:K12386 Q9VCR7 1014 5.1e-108 Cystinosin homolog OS=Drosophila melanogaster GN=CG17119 PE=1 SV=2 PF13174//PF13181//PF00522//PF13414//PF04194//PF13176//PF13374//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//VPR/VPX protein//TPR repeat//Programmed cell death protein 2, C-terminal putative domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019058 viral life cycle GO:0005515 protein binding GO:0005737//GO:0042025 cytoplasm//host cell nucleus KOG3145 Cystine transporter Cystinosin Cluster-8309.39794 BP_3 7.81 2.27 457 642922291 XP_008193096.1 649 1.6e-65 PREDICTED: uncharacterized protein LOC661530 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02270 Transcription initiation factor IIF, beta subunit GO:0006366//GO:0006367 transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter -- -- GO:0005674 transcription factor TFIIF complex -- -- Cluster-8309.39795 BP_3 197.79 1.12 8794 546684662 ERL94279.1 3287 0.0e+00 hypothetical protein D910_11560 [Dendroctonus ponderosae] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2747 6.9e-309 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00813//PF00520//PF05887 FliP family//Ion transport protein//Procyclic acidic repetitive protein (PARP) GO:0006811//GO:0009306//GO:0055085 ion transport//protein secretion//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.39798 BP_3 457.87 5.72 4150 642915533 XP_008190655.1 1572 1.4e-171 PREDICTED: tyrosine-protein phosphatase non-receptor type 61F isoform X1 [Tribolium castaneum] -- -- -- -- -- K18026 PTPN2, PTPT tyrosine-protein phosphatase non-receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18026 Q9W0G1 859 2.7e-90 Tyrosine-protein phosphatase non-receptor type 61F OS=Drosophila melanogaster GN=Ptp61F PE=1 SV=1 PF00102//PF00782//PF08043 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Xin repeat GO:0006470//GO:0006570//GO:0030036 protein dephosphorylation//tyrosine metabolic process//actin cytoskeleton organization GO:0008138//GO:0003779//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//actin binding//protein tyrosine phosphatase activity GO:0030054 cell junction -- -- Cluster-8309.39802 BP_3 486.80 8.06 3203 546682247 ERL92208.1 1592 5.2e-174 hypothetical protein D910_09528, partial [Dendroctonus ponderosae] -- -- -- -- -- K08200 SLC22A3, OCT3 MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08200 Q9VCA2 648 6.2e-66 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07578//PF08573//PF00083//PF07690 Lipid A Biosynthesis N-terminal domain//DNA repair protein endonuclease SAE2/CtIP C-terminus//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006281//GO:0055085//GO:0009245//GO:0006308//GO:0000077 DNA repair//transmembrane transport//lipid A biosynthetic process//DNA catabolic process//DNA damage checkpoint GO:0022857//GO:0008915//GO:0000014 transmembrane transporter activity//lipid-A-disaccharide synthase activity//single-stranded DNA endodeoxyribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.39804 BP_3 35.65 0.41 4473 91092998 XP_968397.1 693 1.3e-69 PREDICTED: ras-related protein Rac1 [Tribolium castaneum]>gi|270004802|gb|EFA01250.1| Ras-related protein Rac1 [Tribolium castaneum] 751452676 XM_011182416.1 132 8.50684e-60 PREDICTED: Bactrocera cucurbitae ras-related protein Rac1 (LOC105211120), mRNA K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 Q6RUV5 680 1.7e-69 Ras-related C3 botulinum toxin substrate 1 OS=Rattus norvegicus GN=Rac1 PE=1 SV=1 PF08477//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0005622//GO:0016020 intracellular//membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.39806 BP_3 595.33 7.11 4325 642912938 XP_008201315.1 858 9.1e-89 PREDICTED: antichymotrypsin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80034 546 5.6e-54 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 PF01080//PF07225 Presenilin//NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0015992//GO:0006744//GO:0006814//GO:0006120 proton transport//ubiquinone biosynthetic process//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0004190 NADH dehydrogenase (ubiquinone) activity//aspartic-type endopeptidase activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane -- -- Cluster-8309.39807 BP_3 463.00 23.43 1244 642912419 XP_008193351.1 596 6.3e-59 PREDICTED: uncharacterized protein LOC103313009 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39808 BP_3 302.41 6.90 2404 270001539 EEZ97986.1 1963 3.7e-217 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 364 0 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1031 1.8e-110 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.39809 BP_3 46.81 0.58 4199 270001539 EEZ97986.1 2008 3.9e-222 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 9.09024e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1089 5.9e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.3981 BP_3 15.57 0.49 1810 332373040 AEE61661.1 1291 2.3e-139 unknown [Dendroctonus ponderosae]>gi|478250242|gb|ENN70742.1| hypothetical protein YQE_12531, partial [Dendroctonus ponderosae]>gi|546685939|gb|ERL95353.1| hypothetical protein D910_12618 [Dendroctonus ponderosae] -- -- -- -- -- K03142 TFIIH2, GTF2H2, SSL1 transcription initiation factor TFIIH subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03142 Q2TBV5 828 4.7e-87 General transcription factor IIH subunit 2 OS=Bos taurus GN=GTF2H2 PE=2 SV=1 PF01363//PF07649//PF07975 FYVE zinc finger//C1-like domain//TFIIH C1-like domain GO:0006281//GO:0055114 DNA repair//oxidation-reduction process GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 Cluster-8309.39812 BP_3 670.06 7.50 4600 91092690 XP_971771.1 1734 2.6e-190 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 5.04748e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 888 1.3e-93 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.39813 BP_3 205.00 6.45 1824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03975 CheD chemotactic sensory transduction GO:0006935//GO:0006807 chemotaxis//nitrogen compound metabolic process GO:0050568 protein-glutamine glutaminase activity -- -- -- -- Cluster-8309.39814 BP_3 7970.72 78.16 5207 91092436 XP_968632.1 5905 0.0e+00 PREDICTED: laminin subunit gamma-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 4317 0.0e+00 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 PF06008//PF01466//PF02346 Laminin Domain I//Skp1 family, dimerisation domain//Chordopoxvirus multifunctional envelope protein A27 GO:0045995//GO:0006511//GO:0030155//GO:0019064//GO:0007165//GO:0030334 regulation of embryonic development//ubiquitin-dependent protein catabolic process//regulation of cell adhesion//fusion of virus membrane with host plasma membrane//signal transduction//regulation of cell migration GO:0005102 receptor binding GO:0019031 viral envelope KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.39815 BP_3 627.25 5.30 6000 195108339 XP_001998750.1 3391 0.0e+00 GI23457 [Drosophila mojavensis]>gi|193915344|gb|EDW14211.1| GI23457 [Drosophila mojavensis] 749782328 XM_011147030.1 172 6.64262e-82 PREDICTED: Harpegnathos saltator bifunctional glutamate/proline--tRNA ligase (LOC105186669), mRNA K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 P28668 3300 0.0e+00 Bifunctional glutamate/proline--tRNA ligase OS=Drosophila melanogaster GN=Aats-glupro PE=1 SV=2 PF00749//PF00587//PF00992//PF00458//PF09180//PF02146//PF03950//PF06971 tRNA synthetases class I (E and Q), catalytic domain//tRNA synthetase class II core domain (G, H, P, S and T)//Troponin//WHEP-TRS domain//Prolyl-tRNA synthetase, C-terminal//Sir2 family//tRNA synthetases class I (E and Q), anti-codon binding domain//Putative DNA-binding protein N-terminus GO:0043039//GO:0006433//GO:0006418//GO:0051775//GO:0045892//GO:0006560//GO:0006525 tRNA aminoacylation//prolyl-tRNA aminoacylation//tRNA aminoacylation for protein translation//response to redox state//negative regulation of transcription, DNA-templated//proline metabolic process//arginine metabolic process GO:0016876//GO:0004812//GO:0004827//GO:0000166//GO:0070403//GO:0005524 ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity//proline-tRNA ligase activity//nucleotide binding//NAD+ binding//ATP binding GO:0005737//GO:0005861 cytoplasm//troponin complex KOG4163 Prolyl-tRNA synthetase Cluster-8309.39816 BP_3 151.74 1.30 5914 642914669 XP_008190307.1 3036 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.25905e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.7e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39817 BP_3 416.80 3.74 5668 642914671 XP_008190309.1 3000 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.0808e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.6e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39818 BP_3 300.03 3.30 4675 91078972 XP_974414.1 2664 3.8e-298 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 1610 2.6e-177 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.39819 BP_3 742.23 14.37 2781 642933817 XP_008197388.1 565 5.5e-55 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.3982 BP_3 4.00 0.37 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39820 BP_3 298.12 13.26 1375 91079218 XP_970039.1 1033 1.5e-109 PREDICTED: peroxisomal biogenesis factor 3 [Tribolium castaneum]>gi|270003587|gb|EFA00035.1| hypothetical protein TcasGA2_TC002842 [Tribolium castaneum] -- -- -- -- -- K13336 PEX3 peroxin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K13336 Q9JJK4 490 5.6e-48 Peroxisomal biogenesis factor 3 OS=Rattus norvegicus GN=Pex3 PE=1 SV=1 PF04882 Peroxin-3 GO:0007031 peroxisome organization -- -- GO:0005779 integral component of peroxisomal membrane KOG4444 Peroxisomal assembly protein PEX3 Cluster-8309.39823 BP_3 1837.89 62.33 1713 642931553 XP_966693.3 2164 1.3e-240 PREDICTED: V-type proton ATPase subunit H isoform X1 [Tribolium castaneum]>gi|629511289|gb|AHY84718.1| V-type proton ATPase subunit H variant-1 [Tribolium castaneum] 642931552 XM_961600.3 449 0 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1824 1.4e-202 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF02985//PF01602//PF11698//PF00514 HEAT repeat//Adaptin N terminal region//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0016192//GO:0015991//GO:0006886 vesicle-mediated transport//ATP hydrolysis coupled proton transport//intracellular protein transport GO:0005515//GO:0016820 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0000221 membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.39824 BP_3 1313.98 14.17 4760 91087995 XP_973673.1 4127 0.0e+00 PREDICTED: protein transport protein Sec31A [Tribolium castaneum] -- -- -- -- -- K14005 SEC31 protein transport protein SEC31 http://www.genome.jp/dbget-bin/www_bget?ko:K14005 Q7SYD5 1892 5.2e-210 Protein transport protein Sec31A OS=Danio rerio GN=sec31a PE=2 SV=1 PF05008//PF00400//PF02840//PF07904//PF00830 Vesicle transport v-SNARE protein N-terminus//WD domain, G-beta repeat//Prp18 domain//Chromatin modification-related protein EAF7//Ribosomal L28 family GO:0042254//GO:0006355//GO:0006886//GO:0008380 ribosome biogenesis//regulation of transcription, DNA-templated//intracellular protein transport//RNA splicing GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0016020//GO:0005840//GO:0043189//GO:0005681//GO:0005634 membrane//ribosome//H4/H2A histone acetyltransferase complex//spliceosomal complex//nucleus KOG0307 Vesicle coat complex COPII, subunit SEC31 Cluster-8309.39825 BP_3 1999.51 21.16 4846 91087995 XP_973673.1 4127 0.0e+00 PREDICTED: protein transport protein Sec31A [Tribolium castaneum] -- -- -- -- -- K14005 SEC31 protein transport protein SEC31 http://www.genome.jp/dbget-bin/www_bget?ko:K14005 Q7SYD5 1892 5.3e-210 Protein transport protein Sec31A OS=Danio rerio GN=sec31a PE=2 SV=1 PF07904//PF02840//PF00830//PF05008//PF00400 Chromatin modification-related protein EAF7//Prp18 domain//Ribosomal L28 family//Vesicle transport v-SNARE protein N-terminus//WD domain, G-beta repeat GO:0006886//GO:0008380//GO:0006355//GO:0042254 intracellular protein transport//RNA splicing//regulation of transcription, DNA-templated//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005634//GO:0043189//GO:0005681//GO:0016020//GO:0005840 nucleus//H4/H2A histone acetyltransferase complex//spliceosomal complex//membrane//ribosome KOG0307 Vesicle coat complex COPII, subunit SEC31 Cluster-8309.39827 BP_3 1042.98 43.14 1457 642922240 XP_008193073.1 1363 8.5e-148 PREDICTED: sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [Tribolium castaneum]>gi|270007452|gb|EFA03900.1| hypothetical protein TcasGA2_TC014030 [Tribolium castaneum] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 932 3.3e-99 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF00287//PF05011 Sodium / potassium ATPase beta chain//Lariat debranching enzyme, C-terminal domain GO:0006814//GO:0006397//GO:0046034//GO:0006813 sodium ion transport//mRNA processing//ATP metabolic process//potassium ion transport GO:0005391//GO:0016788 sodium:potassium-exchanging ATPase activity//hydrolase activity, acting on ester bonds GO:0005890//GO:0016020 sodium:potassium-exchanging ATPase complex//membrane KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.39829 BP_3 34.73 0.43 4155 91084907 XP_969916.1 3578 0.0e+00 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 392 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2849 0.0e+00 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911//PF00551 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain//Formyl transferase GO:0009058//GO:0055114//GO:0032259//GO:0008152 biosynthetic process//oxidation-reduction process//methylation//metabolic process GO:0016742//GO:0008168//GO:0016620//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//methyltransferase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.39830 BP_3 360.22 4.93 3813 642930595 XP_001807608.2 1817 5.0e-200 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01783//PF03091//PF00240 Ribosomal L32p protein family//CutA1 divalent ion tolerance protein//Ubiquitin family GO:0010038//GO:0006412//GO:0042254 response to metal ion//translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840//GO:0015934 ribosome//large ribosomal subunit -- -- Cluster-8309.39831 BP_3 83.97 1.58 2848 642927427 XP_008195268.1 1097 1.2e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF16622 Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.39833 BP_3 116.85 0.79 7453 642914570 XP_008190269.1 2714 9.5e-304 PREDICTED: dnaJ homolog subfamily C member 10-like [Tribolium castaneum] -- -- -- -- -- K09530 DNAJC10 DnaJ homolog subfamily C member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09530 Q5R5L3 1304 1.2e-141 DnaJ homolog subfamily C member 10 OS=Pongo abelii GN=DNAJC10 PE=2 SV=1 PF01216//PF00085//PF08534//PF00071//PF00578 Calsequestrin//Thioredoxin//Redoxin//Ras family//AhpC/TSA family GO:0007264//GO:0045454//GO:0055114 small GTPase mediated signal transduction//cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0005525//GO:0005509//GO:0016209 oxidoreductase activity//GTP binding//calcium ion binding//antioxidant activity -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.39834 BP_3 1042.00 11.97 4487 642922942 XP_008200462.1 3059 0.0e+00 PREDICTED: GRIP and coiled-coil domain-containing protein 2 [Tribolium castaneum]>gi|270006579|gb|EFA03027.1| hypothetical protein TcasGA2_TC010451 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 478 4.5e-46 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.39836 BP_3 1211.18 8.70 6998 478257467 ENN77623.1 2412 9.3e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 795110653 XM_012026968.1 101 2.28044e-42 PREDICTED: Vollenhovia emeryi alpha-protein kinase 1 (LOC105570040), transcript variant X5, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 3.2e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF00408//PF00097//PF16672//PF14634//PF13639//PF00076//PF15965//PF02880//PF02879//PF09726//PF02878 Phosphoglucomutase/phosphomannomutase, C-terminal domain//Zinc finger, C3HC4 type (RING finger)//Ragulator complex protein LAMTOR5//zinc-RING finger domain//Ring finger domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//TRAF-like zinc-finger//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Transmembrane protein//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0043066//GO:0019079//GO:0071704//GO:0043154//GO:0005975 negative regulation of apoptotic process//viral genome replication//organic substance metabolic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//carbohydrate metabolic process GO:0005515//GO:0046872//GO:0008270//GO:0003676//GO:0016868 protein binding//metal ion binding//zinc ion binding//nucleic acid binding//intramolecular transferase activity, phosphotransferases GO:0016021//GO:0071986//GO:0005737 integral component of membrane//Ragulator complex//cytoplasm KOG0625 Phosphoglucomutase Cluster-8309.39839 BP_3 447.03 3.25 6927 270003642 EFA00090.1 2554 3.2e-285 hypothetical protein TcasGA2_TC002905 [Tribolium castaneum] 642916410 XM_008192791.1 112 1.73261e-48 PREDICTED: Tribolium castaneum uncharacterized LOC664255 (LOC664255), transcript variant X3, mRNA K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 702 7.3e-72 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF00536//PF08040//PF07647//PF00595//PF02198//PF13180 SAM domain (Sterile alpha motif)//MNLL subunit//SAM domain (Sterile alpha motif)//PDZ domain (Also known as DHR or GLGF)//Sterile alpha motif (SAM)/Pointed domain//PDZ domain GO:0006118 obsolete electron transport GO:0005515//GO:0003954//GO:0043565 protein binding//NADH dehydrogenase activity//sequence-specific DNA binding GO:0005739//GO:0005634 mitochondrion//nucleus KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.3984 BP_3 13.00 0.36 2047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.39841 BP_3 203.58 11.19 1169 644996952 XP_008213272.1 724 8.5e-74 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Nasonia vitripennis] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q9Y4D2 427 9.6e-41 Sn1-specific diacylglycerol lipase alpha OS=Homo sapiens GN=DAGLA PE=1 SV=3 PF07168 Ureide permease GO:0071705 nitrogen compound transport -- -- -- -- KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.39842 BP_3 673.85 3.36 9961 642922507 XP_008193202.1 9553 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X1 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.54909e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1766 4.4e-195 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF00632//PF04625//PF00658//PF11547 HECT-domain (ubiquitin-transferase)//DEC-1 protein, N-terminal region//Poly-adenylate binding protein, unique domain//E3 ubiquitin ligase EDD GO:0016567//GO:0007304 protein ubiquitination//chorion-containing eggshell formation GO:0043130//GO:0005213//GO:0003723//GO:0004842 ubiquitin binding//structural constituent of chorion//RNA binding//ubiquitin-protein transferase activity GO:0005576//GO:0042600 extracellular region//chorion KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.39844 BP_3 31.67 0.68 2551 642920869 XP_008192593.1 1746 5.7e-192 PREDICTED: protein turtle isoform X8 [Tribolium castaneum] 642920870 XM_008194372.1 138 2.22918e-63 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X14, mRNA -- -- -- -- Q967D7 486 3.0e-47 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39848 BP_3 66.92 1.04 3386 91089643 XP_973832.1 1255 6.6e-135 PREDICTED: solute carrier family 25 member 38-A isoform X2 [Tribolium castaneum]>gi|270011349|gb|EFA07797.1| hypothetical protein TcasGA2_TC005358 [Tribolium castaneum] -- -- -- -- -- K15118 SLC25A38 solute carrier family 25, member 38 http://www.genome.jp/dbget-bin/www_bget?ko:K15118 Q08CI8 782 1.9e-81 Solute carrier family 25 member 38-A OS=Danio rerio GN=slc25a38a PE=2 SV=2 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0766 Predicted mitochondrial carrier protein Cluster-8309.39849 BP_3 35.45 0.33 5511 642927078 XP_008195127.1 1453 1.2e-157 PREDICTED: probable G-protein coupled receptor Mth-like 5 [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VGG8 1038 6.4e-111 Probable G-protein coupled receptor Mth-like 5 OS=Drosophila melanogaster GN=mthl5 PE=2 SV=2 PF02742//PF00001 Iron dependent repressor, metal binding and dimerisation domain//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0046983//GO:0046914//GO:0004930 protein dimerization activity//transition metal ion binding//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.39850 BP_3 447.65 3.85 5892 642914669 XP_008190307.1 3036 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.24311e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.7e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39853 BP_3 970.91 51.19 1206 642920923 XP_008192617.1 925 4.3e-97 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P45376 515 6.2e-51 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.39854 BP_3 5523.95 37.19 7450 270014225 EFA10673.1 5723 0.0e+00 muscle-specific protein 300 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 816 4.8e-85 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF00435//PF14554//PF10541 Spectrin repeat//VEGF heparin-binding domain//Nuclear envelope localisation domain -- -- GO:0005515//GO:0008201 protein binding//heparin binding GO:0016021 integral component of membrane -- -- Cluster-8309.39856 BP_3 354.55 7.08 2707 546672806 ERL84562.1 1170 3.8e-125 hypothetical protein D910_01991 [Dendroctonus ponderosae] 462310482 APGK01047306.1 75 2.48587e-28 Dendroctonus ponderosae Seq01047316, whole genome shotgun sequence -- -- -- -- Q3ZBG9 786 5.2e-82 Phospholipid scramblase 2 OS=Bos taurus GN=PLSCR2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0621 Phospholipid scramblase Cluster-8309.39857 BP_3 2937.16 120.77 1464 91086655 XP_967836.1 1659 4.0e-182 PREDICTED: minor histocompatibility antigen H13 [Tribolium castaneum]>gi|270010389|gb|EFA06837.1| hypothetical protein TcasGA2_TC009780 [Tribolium castaneum] -- -- -- -- -- K09595 HM13 minor histocompatibility antigen H13 http://www.genome.jp/dbget-bin/www_bget?ko:K09595 Q8TCT9 1170 8.4e-127 Minor histocompatibility antigen H13 OS=Homo sapiens GN=HM13 PE=1 SV=1 PF01080//PF04258 Presenilin//Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.39858 BP_3 419.58 77.97 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39859 BP_3 27.77 0.54 2782 478253101 ENN73474.1 189 2.2e-11 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04508 Viral A-type inclusion protein repeat GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.39861 BP_3 436.06 17.45 1496 546682404 ERL92346.1 568 1.3e-55 hypothetical protein D910_09663 [Dendroctonus ponderosae] -- -- -- -- -- K06832 LGALS8 galectin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K06832 O00214 248 7.0e-20 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.39862 BP_3 599.94 17.49 1945 546682404 ERL92346.1 668 4.4e-67 hypothetical protein D910_09663 [Dendroctonus ponderosae] -- -- -- -- -- K06832 LGALS8 galectin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K06832 O00214 248 9.1e-20 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.39864 BP_3 62.60 1.53 2267 817056987 XP_012269382.1 1267 1.8e-136 PREDICTED: casein kinase I isoform alpha isoform X4 [Athalia rosae] 657560379 XM_008285733.1 238 5.08668e-119 PREDICTED: Stegastes partitus casein kinase 1, delta (csnk1d), mRNA K08960 CSNK1E casein kinase 1, epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K08960 Q5ZLL1 1211 2.3e-131 Casein kinase I isoform epsilon OS=Gallus gallus GN=CSNK1E PE=2 SV=2 PF00069//PF07714//PF05445 Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.39865 BP_3 212.55 4.26 2698 546671969 ERL84051.1 1630 1.7e-178 hypothetical protein D910_01380 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9GYU8 740 1.1e-76 Nuclear pore complex protein Nup88 OS=Drosophila melanogaster GN=mbo PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39867 BP_3 2289.00 40.39 3023 478249890 ENN70397.1 973 2.9e-102 hypothetical protein YQE_12903, partial [Dendroctonus ponderosae]>gi|546683396|gb|ERL93215.1| hypothetical protein D910_10511 [Dendroctonus ponderosae] 507621445 XM_004625352.1 143 4.3959e-66 PREDICTED: Octodon degus ADP-ribosylation factor-like 8A (Arl8a), transcript variant X1, mRNA K07955 ARL8 ADP-ribosylation factor-like protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K07955 Q9NVJ2 895 1.3e-94 ADP-ribosylation factor-like protein 8B OS=Homo sapiens GN=ARL8B PE=1 SV=1 PF00503//PF04670//PF00025//PF00071//PF08477//PF01926 G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0031683//GO:0003924 GTP binding//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0075 GTP-binding ADP-ribosylation factor-like protein Cluster-8309.39868 BP_3 6.39 2.42 418 642928567 XP_008199961.1 407 1.7e-37 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 O18635 256 2.3e-21 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.39869 BP_3 182.90 1.37 6730 642915750 XP_008190789.1 4165 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.88247e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.8e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.3987 BP_3 15.00 0.57 1559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39870 BP_3 181.63 1.74 5314 642919913 XP_008192122.1 1315 1.1e-141 PREDICTED: transcription factor SOX-13 [Tribolium castaneum] 759081689 XM_011352406.1 129 4.70803e-58 PREDICTED: Cerapachys biroi transcription factor SOX-5 (LOC105287028), mRNA K09269 SOX5_6_13 transcription factor SOX5/6/13 (SOX group D) http://www.genome.jp/dbget-bin/www_bget?ko:K09269 P35712 523 3.2e-51 Transcription factor SOX-6 OS=Homo sapiens GN=SOX6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0528 HMG-box transcription factor SOX5 Cluster-8309.39872 BP_3 23.97 0.35 3560 91088789 XP_968000.1 859 5.7e-89 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35859 291 1.7e-24 Insulin-like growth factor-binding protein complex acid labile subunit OS=Rattus norvegicus GN=Igfals PE=1 SV=1 PF00560//PF01943//PF13855 Leucine Rich Repeat//Polysaccharide biosynthesis protein//Leucine rich repeat GO:0000271 polysaccharide biosynthetic process GO:0005515 protein binding GO:0016020 membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.39873 BP_3 1609.00 22.94 3673 91092728 XP_972902.1 2508 3.6e-280 PREDICTED: GTP-binding protein 2 [Tribolium castaneum]>gi|270014879|gb|EFA11327.1| hypothetical protein TcasGA2_TC010866 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BX10 1442 6.1e-158 GTP-binding protein 2 OS=Homo sapiens GN=GTPBP2 PE=1 SV=1 PF03144//PF03193//PF00005//PF01926//PF05676//PF10662//PF00025 Elongation factor Tu domain 2//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Ethanolamine utilisation - propanediol utilisation//ADP-ribosylation factor family GO:0006184//GO:0006744//GO:0006118//GO:0006814//GO:0015992//GO:0006120//GO:0006576 obsolete GTP catabolic process//ubiquinone biosynthetic process//obsolete electron transport//sodium ion transport//proton transport//mitochondrial electron transport, NADH to ubiquinone//cellular biogenic amine metabolic process GO:0016887//GO:0005525//GO:0008137//GO:0005524//GO:0003954//GO:0003924 ATPase activity//GTP binding//NADH dehydrogenase (ubiquinone) activity//ATP binding//NADH dehydrogenase activity//GTPase activity GO:0005739 mitochondrion KOG1143 Predicted translation elongation factor Cluster-8309.39874 BP_3 806.08 22.93 1986 91094127 XP_968492.1 2115 7.3e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 3.1e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0030145//GO:0004177//GO:0008235 manganese ion binding//aminopeptidase activity//metalloexopeptidase activity GO:0005737//GO:0005622 cytoplasm//intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.39877 BP_3 30.28 1.79 1106 332374316 AEE62299.1 608 2.3e-60 unknown [Dendroctonus ponderosae]>gi|478255157|gb|ENN75386.1| hypothetical protein YQE_07938, partial [Dendroctonus ponderosae]>gi|546677194|gb|ERL88076.1| hypothetical protein D910_05465 [Dendroctonus ponderosae] 662192887 XM_008471100.1 80 1.65877e-31 PREDICTED: Diaphorina citri cytochrome c-type heme lyase (LOC103506705), mRNA K01764 E4.4.1.17 cytochrome c heme-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01764 P53702 408 1.4e-38 Cytochrome c-type heme lyase OS=Mus musculus GN=Hccs PE=1 SV=2 PF01265 Cytochrome c/c1 heme lyase GO:0015994 chlorophyll metabolic process GO:0004408 holocytochrome-c synthase activity GO:0005739 mitochondrion KOG3996 Holocytochrome c synthase/heme-lyase Cluster-8309.39880 BP_3 628.20 4.16 7575 91092074 XP_971115.1 1545 3.5e-168 PREDICTED: uncharacterized protein LOC659745 [Tribolium castaneum]>gi|270004682|gb|EFA01130.1| hypothetical protein TcasGA2_TC010343 [Tribolium castaneum] 642917993 XM_966022.2 241 3.69005e-120 PREDICTED: Tribolium castaneum uncharacterized LOC659745 (LOC659745), mRNA K10480 BTBD8 BTB/POZ domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10480 Q5XKL5 240 3.0e-18 BTB/POZ domain-containing protein 8 OS=Homo sapiens GN=BTBD8 PE=2 SV=2 PF07267//PF00651//PF07271//PF15952//PF02517//PF05757 Nucleopolyhedrovirus capsid protein P87//BTB/POZ domain//Cytadhesin P30/P32//Enhancer of split M4 family//CAAX protease self-immunity//Oxygen evolving enhancer protein 3 (PsbQ) GO:0007157//GO:0007423//GO:0015979//GO:0007219//GO:0009405 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules//sensory organ development//photosynthesis//Notch signaling pathway//pathogenesis GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0009523//GO:0016020//GO:0009654//GO:0019898//GO:0016021//GO:0019028 photosystem II//membrane//photosystem II oxygen evolving complex//extrinsic component of membrane//integral component of membrane//viral capsid -- -- Cluster-8309.39882 BP_3 261.76 1.79 7326 642930494 XP_008196427.1 2252 3.5e-250 PREDICTED: CLIP-associating protein isoform X2 [Tribolium castaneum]>gi|270009386|gb|EFA05834.1| hypothetical protein TcasGA2_TC008618 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 A1A5G0 910 5.9e-96 CLIP-associating protein 1 OS=Xenopus tropicalis GN=clasp1 PE=1 SV=1 PF02985//PF01602//PF01528 HEAT repeat//Adaptin N terminal region//Herpesvirus glycoprotein M GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0016020//GO:0030117 membrane//membrane coat -- -- Cluster-8309.39883 BP_3 1312.35 9.28 7107 642930494 XP_008196427.1 2984 0.0e+00 PREDICTED: CLIP-associating protein isoform X2 [Tribolium castaneum]>gi|270009386|gb|EFA05834.1| hypothetical protein TcasGA2_TC008618 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 928 4.7e-98 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF01528//PF12844//PF11640//PF02985 Herpesvirus glycoprotein M//Helix-turn-helix domain//Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0004674//GO:0043565 protein binding//protein serine/threonine kinase activity//sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.39884 BP_3 2584.70 467.73 558 478255706 ENN75917.1 453 1.1e-42 hypothetical protein YQE_07558, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39886 BP_3 63.69 0.82 4040 91090196 XP_967193.1 2643 8.8e-296 PREDICTED: cyclin-G-associated kinase [Tribolium castaneum]>gi|270013468|gb|EFA09916.1| hypothetical protein TcasGA2_TC012067 [Tribolium castaneum] -- -- -- -- -- K08855 GAK cyclin G-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08855 P97874 1636 2.1e-180 Cyclin-G-associated kinase OS=Rattus norvegicus GN=Gak PE=2 SV=1 PF07714//PF00782//PF00069 Protein tyrosine kinase//Dual specificity phosphatase, catalytic domain//Protein kinase domain GO:0016310//GO:0006470//GO:0006468 phosphorylation//protein dephosphorylation//protein phosphorylation GO:0005524//GO:0000166//GO:0004672//GO:0008138 ATP binding//nucleotide binding//protein kinase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1989 ARK protein kinase family Cluster-8309.39887 BP_3 155.93 0.99 7856 649572303 NP_001280516.1 1401 1.8e-151 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 642931552 XM_961600.3 337 1.64749e-173 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1298 6.5e-141 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF01602//PF11698//PF02778//PF00514//PF02297//PF02985//PF01974 Adaptin N terminal region//V-ATPase subunit H//tRNA intron endonuclease, N-terminal domain//Armadillo/beta-catenin-like repeat//Cytochrome oxidase c subunit VIb//HEAT repeat//tRNA intron endonuclease, catalytic C-terminal domain GO:0006123//GO:0006886//GO:0016192//GO:0015992//GO:0051252//GO:0006388//GO:0006119//GO:0015991 mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//vesicle-mediated transport//proton transport//regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961//GO:0000213//GO:0016820//GO:0005515//GO:0004129 proton-transporting ATPase activity, rotational mechanism//tRNA-intron endonuclease activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//cytochrome-c oxidase activity GO:0005739//GO:0000221//GO:0045277//GO:0000214//GO:0030117 mitochondrion//vacuolar proton-transporting V-type ATPase, V1 domain//respiratory chain complex IV//tRNA-intron endonuclease complex//membrane coat KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.39888 BP_3 127.09 3.04 2310 642915291 XP_008190557.1 1285 1.5e-138 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 605 4.3e-61 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.39889 BP_3 91.36 1.79 2755 642915291 XP_008190557.1 1180 2.7e-126 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8VI02 565 2.2e-56 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Rattus norvegicus GN=Ppp4r1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.39891 BP_3 1764.37 62.02 1663 642915291 XP_008190557.1 1102 1.8e-117 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 768 3.9e-80 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF00311//PF01602//PF02985//PF10410 Phosphoenolpyruvate carboxylase//Adaptin N terminal region//HEAT repeat//DnaB-helicase binding domain of primase GO:0006099//GO:0006094//GO:0015977//GO:0019643//GO:0016192//GO:0006886 tricarboxylic acid cycle//gluconeogenesis//carbon fixation//reductive tricarboxylic acid cycle//vesicle-mediated transport//intracellular protein transport GO:0016779//GO:0008964//GO:0005515 nucleotidyltransferase activity//phosphoenolpyruvate carboxylase activity//protein binding GO:0030117 membrane coat -- -- Cluster-8309.39892 BP_3 29.03 0.41 3740 91092536 XP_967769.1 1697 4.0e-186 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 368 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K04409 PAK1 p21-activated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04409 P35465 1332 3.5e-145 Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004672//GO:0004674//GO:0016773 ATP binding//protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.39894 BP_3 3570.29 58.41 3238 189241130 XP_973380.2 3292 0.0e+00 PREDICTED: melanotransferrin [Tribolium castaneum]>gi|270013329|gb|EFA09777.1| hypothetical protein TcasGA2_TC011919 [Tribolium castaneum] -- -- -- -- -- K06569 MFI2 melanoma-associated antigen p97 http://www.genome.jp/dbget-bin/www_bget?ko:K06569 O97490 629 1.0e-63 Melanotransferrin OS=Oryctolagus cuniculus GN=Mfi2 PE=2 SV=1 PF00172 Fungal Zn(2)-Cys(6) binuclear cluster domain GO:0006355//GO:0044699 regulation of transcription, DNA-templated//single-organism process GO:0008270//GO:0000981 zinc ion binding//RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.39895 BP_3 61.94 1.11 2982 91078902 XP_973455.1 976 1.3e-102 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q3ZBT5 467 5.6e-45 Syntaxin-7 OS=Bos taurus GN=STX7 PE=2 SV=1 PF00804//PF00015//PF02561//PF00957//PF05739 Syntaxin//Methyl-accepting chemotaxis protein (MCP) signalling domain//Flagellar protein FliS//Synaptobrevin//SNARE domain GO:0007165//GO:0016192 signal transduction//vesicle-mediated transport GO:0004871//GO:0005515 signal transducer activity//protein binding GO:0016020//GO:0016021//GO:0009288 membrane//integral component of membrane//bacterial-type flagellum KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.39896 BP_3 17.11 0.31 2957 642915652 XP_008190697.1 1493 1.4e-162 PREDICTED: integrin-alpha FG-GAP repeat-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q969R8 589 4.0e-59 Integrin-alpha FG-GAP repeat-containing protein 2 OS=Homo sapiens GN=ITFG2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1568 Mitochondrial inner membrane protease, subunit IMP2 Cluster-8309.39899 BP_3 474.99 6.70 3711 270013391 EFA09839.1 785 2.3e-80 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 194893319 XM_001977817.1 90 1.56894e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- P08897 240 1.5e-18 Collagenase OS=Hypoderma lineatum PE=1 SV=3 PF00008//PF00089//PF06373 EGF-like domain//Trypsin//Cocaine and amphetamine regulated transcript protein (CART) GO:0009267//GO:0000186//GO:0007186//GO:0006508//GO:0001678//GO:0008343//GO:0032099 cellular response to starvation//activation of MAPKK activity//G-protein coupled receptor signaling pathway//proteolysis//cellular glucose homeostasis//adult feeding behavior//negative regulation of appetite GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding GO:0005615 extracellular space -- -- Cluster-8309.399 BP_3 42.58 1.05 2244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3990 BP_3 4.00 0.33 869 827556941 XP_012549781.1 530 2.0e-51 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39900 BP_3 20.86 0.63 1876 189238341 XP_966817.2 1236 5.8e-133 PREDICTED: sorting and assembly machinery component 50 homolog [Tribolium castaneum] -- -- -- -- -- K07277 SAM50, TOB55, bamA outer membrane protein insertion porin family http://www.genome.jp/dbget-bin/www_bget?ko:K07277 Q6PA35 580 2.8e-58 Sorting and assembly machinery component 50 homolog B OS=Xenopus laevis GN=samm50-b PE=2 SV=1 PF01103 Surface antigen -- -- -- -- GO:0019867 outer membrane KOG2602 Predicted cell surface protein homologous to bacterial outer membrane proteins Cluster-8309.39901 BP_3 119.59 6.37 1197 403234001 AFR31785.1 666 4.6e-67 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P08836 199 2.7e-14 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.39902 BP_3 3062.80 69.36 2420 91076170 XP_971503.1 2162 3.1e-240 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 401 0 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 503 3.1e-49 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.39903 BP_3 1522.20 69.39 1349 91085965 XP_971530.1 888 9.4e-93 PREDICTED: protein ERGIC-53 [Tribolium castaneum]>gi|270010174|gb|EFA06622.1| hypothetical protein TcasGA2_TC009540 [Tribolium castaneum] -- -- -- -- -- K10080 LMAN1, ERGIC53 lectin, mannose-binding 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10080 Q9TU32 266 5.2e-22 Protein ERGIC-53 OS=Chlorocebus aethiops GN=LMAN1 PE=2 SV=1 PF17001//PF08649//PF06008//PF01442//PF00657//PF00621//PF16740//PF06320 Type III secretion basal body protein I, YscI, HrpB, PscI//DASH complex subunit Dad1//Laminin Domain I//Apolipoprotein A1/A4/E domain//GDSL-like Lipase/Acylhydrolase//RhoGEF domain//Spindle and kinetochore-associated protein 2//GCN5-like protein 1 (GCN5L1) GO:0043087//GO:0030155//GO:0030472//GO:0042157//GO:0006869//GO:0051301//GO:0031110//GO:0000090//GO:0007067//GO:0007059//GO:0045995//GO:0035023//GO:0007165//GO:0030334//GO:0009306 regulation of GTPase activity//regulation of cell adhesion//mitotic spindle organization in nucleus//lipoprotein metabolic process//lipid transport//cell division//regulation of microtubule polymerization or depolymerization//mitotic anaphase//mitotic nuclear division//chromosome segregation//regulation of embryonic development//regulation of Rho protein signal transduction//signal transduction//regulation of cell migration//protein secretion GO:0008017//GO:0005089//GO:0008289//GO:0016788//GO:0005102 microtubule binding//Rho guanyl-nucleotide exchange factor activity//lipid binding//hydrolase activity, acting on ester bonds//receptor binding GO:0016020//GO:0000940//GO:0005576//GO:0031083//GO:0072686//GO:0042729//GO:0005876//GO:0045298 membrane//condensed chromosome outer kinetochore//extracellular region//BLOC-1 complex//mitotic spindle//DASH complex//spindle microtubule//tubulin complex -- -- Cluster-8309.39907 BP_3 398.67 24.25 1084 -- -- -- -- -- 642913273 XM_008203244.1 72 4.54943e-27 PREDICTED: Tribolium castaneum troponin T, skeletal muscle (LOC663893), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39909 BP_3 92.40 3.13 1716 642917061 XP_008191104.1 1831 5.4e-202 PREDICTED: roundabout homolog 2 [Tribolium castaneum] 642917060 XM_008192882.1 305 2.17878e-156 PREDICTED: Tribolium castaneum roundabout (LOC655427), mRNA K06754 ROBO2 roundabout, axon guidance receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06754 Q9HCK4 1014 1.2e-108 Roundabout homolog 2 OS=Homo sapiens GN=ROBO2 PE=1 SV=2 PF13895//PF08534 Immunoglobulin domain//Redoxin -- -- GO:0005515//GO:0016491 protein binding//oxidoreductase activity -- -- KOG4222 Axon guidance receptor Dscam Cluster-8309.39911 BP_3 44.81 7.44 582 546681162 ERL91306.1 399 2.0e-36 hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39912 BP_3 1243.73 9.99 6294 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 2.9e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF00448//PF03193//PF00005//PF02367//PF01926//PF13304 SRP54-type protein, GTPase domain//Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006200//GO:0006614//GO:0002949 obsolete ATP catabolic process//SRP-dependent cotranslational protein targeting to membrane//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0005525//GO:0005524//GO:0016887 GTPase activity//GTP binding//ATP binding//ATPase activity -- -- -- -- Cluster-8309.39913 BP_3 342.02 3.01 5760 642918509 XP_008191502.1 6566 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 [Tribolium castaneum]>gi|270003219|gb|EEZ99666.1| hypothetical protein TcasGA2_TC002423 [Tribolium castaneum] 585685897 XM_006820162.1 113 4.00332e-49 PREDICTED: Saccoglossus kowalevskii brefeldin A-inhibited guanine nucleotide-exchange protein 1-like (LOC100366823), mRNA K18442 ARFGEF, BIG brefeldin A-inhibited guanine nucleotide-exchange protein http://www.genome.jp/dbget-bin/www_bget?ko:K18442 Q9Y6D5 4863 0.0e+00 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens GN=ARFGEF2 PE=1 SV=3 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity GO:0005622 intracellular KOG0929 Guanine nucleotide exchange factor Cluster-8309.39914 BP_3 33.66 1.68 1258 478251547 ENN72009.1 260 5.8e-20 hypothetical protein YQE_11300, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39915 BP_3 743.85 3.70 9981 642926973 XP_008195085.1 2249 1.1e-249 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 1.1e-76 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF05529//PF02948//PF00621//PF06206//PF03650//PF05791 B-cell receptor-associated protein 31-like//Amelogenin//RhoGEF domain//CpeT/CpcT family (DUF1001)//Uncharacterised protein family (UPF0041)//Bacillus haemolytic enterotoxin (HBL) GO:0043087//GO:0017009//GO:0009405//GO:0035023//GO:0007275//GO:0006850//GO:0006886 regulation of GTPase activity//protein-phycocyanobilin linkage//pathogenesis//regulation of Rho protein signal transduction//multicellular organismal development//mitochondrial pyruvate transport//intracellular protein transport GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005578//GO:0016020//GO:0016021//GO:0005743//GO:0005783 proteinaceous extracellular matrix//membrane//integral component of membrane//mitochondrial inner membrane//endoplasmic reticulum -- -- Cluster-8309.39917 BP_3 23.00 0.89 1531 642912421 XP_008193352.1 714 1.6e-72 PREDICTED: serine protease snake-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 491 4.8e-48 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39920 BP_3 448.66 2.25 9892 270003134 EEZ99581.1 841 1.9e-86 hypothetical protein TcasGA2_TC001567 [Tribolium castaneum] 641653063 XM_003241514.2 58 2.58567e-18 PREDICTED: Acyrthosiphon pisum zinc finger protein ubi-d4 (LOC100161288), transcript variant X3, mRNA K13196 DPF2, REQ zinc finger protein ubi-d4 http://www.genome.jp/dbget-bin/www_bget?ko:K13196 Q9W636 381 1.7e-34 Zinc finger protein ubi-d4 B (Fragment) OS=Xenopus laevis GN=req-b PE=2 SV=2 PF00684//PF00628//PF02064 DnaJ central domain//PHD-finger//MAS20 protein import receptor GO:0006886//GO:0006605 intracellular protein transport//protein targeting GO:0005515//GO:0031072//GO:0051082 protein binding//heat shock protein binding//unfolded protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1244 Predicted transcription factor Requiem/NEURO-D4 Cluster-8309.39922 BP_3 3459.66 55.71 3285 642912959 XP_008201326.1 2898 0.0e+00 PREDICTED: programmed cell death 6-interacting protein [Tribolium castaneum]>gi|270001905|gb|EEZ98352.1| hypothetical protein TcasGA2_TC000807 [Tribolium castaneum] -- -- -- -- -- K12200 PDCD6IP, ALIX, RIM20 programmed cell death 6-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12200 Q9W6C5 1523 2.2e-167 Programmed cell death 6-interacting protein OS=Xenopus laevis GN=pdcd6ip PE=1 SV=1 PF13949//PF17082//PF04111 ALIX V-shaped domain binding to HIV//Spindle Pole Component 29//Autophagy protein Apg6 GO:0006914//GO:0030474 autophagy//spindle pole body duplication GO:0005515//GO:0005200 protein binding//structural constituent of cytoskeleton GO:0005856//GO:0005823 cytoskeleton//central plaque of spindle pole body KOG2220 Predicted signal transduction protein Cluster-8309.39924 BP_3 228.95 1.81 6399 91089853 XP_970874.1 1673 4.2e-183 PREDICTED: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [Tribolium castaneum]>gi|270013647|gb|EFA10095.1| hypothetical protein TcasGA2_TC012273 [Tribolium castaneum] 817186518 XM_012432341.1 237 5.21144e-118 PREDICTED: Orussus abietinus protein phosphatase PP2A 55 kDa regulatory subunit (LOC105703734), transcript variant X6, mRNA K04354 PPP2R2 serine/threonine-protein phosphatase 2A regulatory subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K04354 P36872 1427 5.8e-156 Protein phosphatase PP2A 55 kDa regulatory subunit OS=Drosophila melanogaster GN=tws PE=2 SV=1 PF00400//PF11093//PF13463//PF13465 WD domain, G-beta repeat//Mitochondrial export protein Som1//Winged helix DNA-binding domain//Zinc-finger double domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0046872//GO:0003700//GO:0008601//GO:0005515 metal ion binding//transcription factor activity, sequence-specific DNA binding//protein phosphatase type 2A regulator activity//protein binding GO:0000159//GO:0042720//GO:0005667 protein phosphatase type 2A complex//mitochondrial inner membrane peptidase complex//transcription factor complex KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.39925 BP_3 323.00 4.80 3535 91076520 XP_973486.1 895 3.8e-93 PREDICTED: leucine-rich repeat-containing protein 57 [Tribolium castaneum]>gi|270002609|gb|EEZ99056.1| hypothetical protein TcasGA2_TC004931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INV3 588 6.2e-59 Leucine-rich repeat-containing protein 57 OS=Xenopus laevis GN=lrrc57 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.39926 BP_3 926.98 7.46 6279 642912571 XP_008200914.1 1898 3.4e-209 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 195 1.13857e-94 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 1025 2.3e-109 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF03425//PF03278//PF00617 Carbohydrate binding domain (family 11)//IpaB/EvcA family//RasGEF domain GO:0043087//GO:0007264//GO:0030245//GO:0005982//GO:0009405//GO:0005985 regulation of GTPase activity//small GTPase mediated signal transduction//cellulose catabolic process//starch metabolic process//pathogenesis//sucrose metabolic process GO:0008810//GO:0005085 cellulase activity//guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.39927 BP_3 49.69 0.90 2952 122064577 P81926.2 336 2.1e-28 RecName: Full=Superoxide dismutase [Cu-Zn] [Halocynthia roretzi] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 336 8.6e-30 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.39932 BP_3 728.07 16.50 2419 91086561 XP_975997.1 1036 1.2e-109 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X1 [Tribolium castaneum]>gi|270009775|gb|EFA06223.1| hypothetical protein TcasGA2_TC009072 [Tribolium castaneum] 766927493 XM_011497449.1 59 1.7402e-19 PREDICTED: Ceratosolen solmsi marchali phosphoenolpyruvate carboxykinase [GTP]-like (LOC105360529), mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 934 3.2e-99 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006099//GO:0006094 tricarboxylic acid cycle//gluconeogenesis GO:0005525//GO:0004611//GO:0004613 GTP binding//phosphoenolpyruvate carboxykinase activity//phosphoenolpyruvate carboxykinase (GTP) activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.39934 BP_3 154.87 1.62 4913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02258//PF03798 Shiga-like toxin beta subunit//TLC domain GO:0019836 hemolysis by symbiont of host erythrocytes -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.39935 BP_3 132.06 1.02 6519 189240413 XP_969795.2 2222 9.4e-247 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 186 1.19074e-89 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 Q01167 1019 1.2e-108 Forkhead box protein K2 OS=Homo sapiens GN=FOXK2 PE=1 SV=3 PF00250//PF00498 Forkhead domain//FHA domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.39936 BP_3 206.94 1.56 6690 189240413 XP_969795.2 2244 2.7e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.39192e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.5e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00498//PF00250 FHA domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005515//GO:0043565 transcription factor activity, sequence-specific DNA binding//protein binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.39938 BP_3 254.47 8.19 1790 820858959 XP_012346450.1 487 3.9e-46 PREDICTED: uncharacterized protein LOC100869561 [Apis florea] 645008120 XM_003425686.2 127 2.02571e-57 PREDICTED: Nasonia vitripennis uncharacterized LOC100121483 (LOC100121483), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF03896//PF06459//PF03522//PF02862//PF07168//PF13965//PF00856//PF12326//PF03286//PF03348//PF05529//PF16965 Translocon-associated protein (TRAP), alpha subunit//Ryanodine Receptor TM 4-6//Solute carrier family 12//DDHD domain//Ureide permease//dsRNA-gated channel SID-1//SET domain//N-glycosylation protein//Pox virus Ag35 surface protein//Serine incorporator (Serinc)//B-cell receptor-associated protein 31-like//Ceramide synthase regulator GO:0071705//GO:0034599//GO:0006811//GO:0006816//GO:0015931//GO:0006886//GO:0006810//GO:0033227//GO:0006874 nitrogen compound transport//cellular response to oxidative stress//ion transport//calcium ion transport//nucleobase-containing compound transport//intracellular protein transport//transport//dsRNA transport//cellular calcium ion homeostasis GO:0005219//GO:0005515//GO:0005215//GO:0051033//GO:0046872//GO:0030234 ryanodine-sensitive calcium-release channel activity//protein binding//transporter activity//RNA transmembrane transporter activity//metal ion binding//enzyme regulator activity GO:0030176//GO:0005789//GO:0019031//GO:0005783//GO:0016020//GO:0016021//GO:0005622 integral component of endoplasmic reticulum membrane//endoplasmic reticulum membrane//viral envelope//endoplasmic reticulum//membrane//integral component of membrane//intracellular -- -- Cluster-8309.39940 BP_3 64.45 2.65 1464 642921007 XP_008192651.1 1453 3.1e-158 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 5.84904e-67 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7M734 135 8.7e-07 Otopetrin-1 OS=Rattus norvegicus GN=Otop1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39942 BP_3 434.97 3.23 6774 642921007 XP_008192651.1 2135 1.2e-236 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 2.75579e-66 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7RTS6 149 9.6e-08 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 PF01499 Herpesvirus UL25 family GO:0019072 viral genome packaging -- -- GO:0042025 host cell nucleus KOG4740 Uncharacterized conserved protein Cluster-8309.39943 BP_3 1011.20 6.15 8220 649572303 NP_001280516.1 1401 1.9e-151 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 642931552 XM_961600.3 337 1.72418e-173 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1298 6.8e-141 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF01602//PF00514//PF10723//PF02778//PF02297//PF11698//PF01974//PF00600//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//Replication regulatory protein RepB//tRNA intron endonuclease, N-terminal domain//Cytochrome oxidase c subunit VIb//V-ATPase subunit H//tRNA intron endonuclease, catalytic C-terminal domain//Influenza non-structural protein (NS1)//HEAT repeat GO:0006388//GO:0015991//GO:0006119//GO:0051252//GO:0015992//GO:0006276//GO:0006123//GO:0006886//GO:0016192 tRNA splicing, via endonucleolytic cleavage and ligation//ATP hydrolysis coupled proton transport//oxidative phosphorylation//regulation of RNA metabolic process//proton transport//plasmid maintenance//mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//vesicle-mediated transport GO:0004129//GO:0003723//GO:0016820//GO:0005515//GO:0000213//GO:0046961 cytochrome-c oxidase activity//RNA binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//tRNA-intron endonuclease activity//proton-transporting ATPase activity, rotational mechanism GO:0000214//GO:0030117//GO:0045277//GO:0000221//GO:0005739 tRNA-intron endonuclease complex//membrane coat//respiratory chain complex IV//vacuolar proton-transporting V-type ATPase, V1 domain//mitochondrion KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.39944 BP_3 5090.19 14.98 16672 270010741 EFA07189.1 5418 0.0e+00 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] 407731599 JQ771517.1 1610 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00014//PF05986//PF02714//PF13895//PF00122//PF04545//PF08686 Kunitz/Bovine pancreatic trypsin inhibitor domain//ADAM-TS Spacer 1//Calcium-dependent channel, 7TM region, putative phosphate//Immunoglobulin domain//E1-E2 ATPase//Sigma-70, region 4//PLAC (protease and lacunin) domain GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0005515//GO:0004867//GO:0003677//GO:0004222//GO:0046872//GO:0003700//GO:0008233//GO:0016987//GO:0000166 protein binding//serine-type endopeptidase inhibitor activity//DNA binding//metalloendopeptidase activity//metal ion binding//transcription factor activity, sequence-specific DNA binding//peptidase activity//sigma factor activity//nucleotide binding GO:0005667//GO:0031012//GO:0016020 transcription factor complex//extracellular matrix//membrane KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.39945 BP_3 205.00 25.19 684 226968615 YP_002808564.1 944 1.5e-99 cytochrome c oxidase subunit II [Scylla paramamosain]>gi|225697851|gb|ACO07218.1| cytochrome c oxidase subunit II [Scylla paramamosain]>gi|403311090|gb|AFR34049.1| cytochrome c oxidase subunit II (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 684 0 Scylla paramamosain mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P98021 748 3.4e-78 Cytochrome c oxidase subunit 2 OS=Simulium vittatum GN=COII PE=3 SV=1 -- -- GO:0015992//GO:0006118//GO:0006123//GO:0022904 proton transport//obsolete electron transport//mitochondrial electron transport, cytochrome c to oxygen//respiratory electron transport chain GO:0004129//GO:0020037//GO:0009055//GO:0005507 cytochrome-c oxidase activity//heme binding//electron carrier activity//copper ion binding GO:0045277//GO:0070469//GO:0016021//GO:0005743 respiratory chain complex IV//respiratory chain//integral component of membrane//mitochondrial inner membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.39947 BP_3 13.19 26.04 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39949 BP_3 1028.55 12.73 4187 189239223 XP_973572.2 678 6.5e-68 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 7.79138e-75 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39950 BP_3 46.91 1.27 2078 270016569 EFA13015.1 377 2.6e-33 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q98931 200 3.6e-14 Low-density lipoprotein receptor-related protein 8 OS=Gallus gallus GN=LRP8 PE=1 SV=1 PF07095//PF06769//PF06682 Intracellular growth attenuator protein IgaA//YoeB-like toxin of bacterial type II toxin-antitoxin system//SOCE-associated regulatory factor of calcium homoeostasis GO:0006401//GO:2001256 RNA catabolic process//regulation of store-operated calcium entry GO:0004519 endonuclease activity GO:0030176//GO:0009276//GO:0016021 integral component of endoplasmic reticulum membrane//Gram-negative-bacterium-type cell wall//integral component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.39951 BP_3 268.00 3.61 3870 546680769 ERL90975.1 1094 3.5e-116 hypothetical protein D910_08317 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 254 3.6e-20 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39952 BP_3 48.72 1.40 1968 642930669 XP_008199217.1 327 1.5e-27 PREDICTED: uncharacterized protein LOC657834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06206 CpeT/CpcT family (DUF1001) GO:0017009 protein-phycocyanobilin linkage -- -- -- -- -- -- Cluster-8309.39954 BP_3 222.16 1.05 10493 642927134 XP_008195152.1 1690 7.4e-185 PREDICTED: far upstream element-binding protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 2.7e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF07650//PF10192//PF13184//PF13014//PF00013 KH domain//Rhodopsin-like GPCR transmembrane domain//NusA-like KH domain//KH domain//KH domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.39955 BP_3 250.59 13.58 1181 478255719 ENN75928.1 584 1.5e-57 hypothetical protein YQE_07465, partial [Dendroctonus ponderosae]>gi|546681163|gb|ERL91307.1| hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35501 129 3.5e-06 Esterase E4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39956 BP_3 549.02 7.41 3864 270012348 EFA08796.1 798 7.4e-82 hypothetical protein TcasGA2_TC006490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CZ0 327 1.2e-28 UPF0472 protein C16orf72 OS=Homo sapiens GN=C16orf72 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39957 BP_3 717.58 9.71 3852 270012348 EFA08796.1 798 7.3e-82 hypothetical protein TcasGA2_TC006490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CZ0 327 1.2e-28 UPF0472 protein C16orf72 OS=Homo sapiens GN=C16orf72 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39959 BP_3 653.49 10.42 3315 642923287 XP_008193691.1 2430 3.6e-271 PREDICTED: venom dipeptidyl peptidase 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B1A4F7 1320 7.7e-144 Venom dipeptidyl peptidase 4 OS=Vespula vulgaris PE=1 SV=1 PF00326//PF00930//PF02129 Prolyl oligopeptidase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region//X-Pro dipeptidyl-peptidase (S15 family) GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.39960 BP_3 89.83 1.22 3830 642923287 XP_008193691.1 1731 4.7e-190 PREDICTED: venom dipeptidyl peptidase 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 974 1.2e-103 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF00326//PF00930//PF03583//PF02129 Prolyl oligopeptidase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Secretory lipase//X-Pro dipeptidyl-peptidase (S15 family) GO:0006508//GO:0016042//GO:0046486 proteolysis//lipid catabolic process//glycerolipid metabolic process GO:0016787//GO:0008236//GO:0004806 hydrolase activity//serine-type peptidase activity//triglyceride lipase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.39961 BP_3 544.91 3.87 7070 91078242 XP_970298.1 3331 0.0e+00 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 642939064 XM_008201985.1 402 0 PREDICTED: Tribolium castaneum xenotropic and polytropic retrovirus receptor 1 (LOC100142189), transcript variant X2, mRNA -- -- -- -- Q9UBH6 1815 6.5e-201 Xenotropic and polytropic retrovirus receptor 1 OS=Homo sapiens GN=XPR1 PE=1 SV=1 PF00118//PF03124//PF01504 TCP-1/cpn60 chaperonin family//EXS family//Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0043167//GO:0016307//GO:0005524 ion binding//phosphatidylinositol phosphate kinase activity//ATP binding GO:0016021 integral component of membrane KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.39962 BP_3 779.27 4.45 8725 642933755 XP_008191527.1 6952 0.0e+00 PREDICTED: huntingtin-like [Tribolium castaneum] -- -- -- -- -- K04533 HD huntingtin http://www.genome.jp/dbget-bin/www_bget?ko:K04533 P42858 2531 7.6e-284 Huntingtin OS=Homo sapiens GN=HTT PE=1 SV=2 PF08715//PF02985 Papain like viral protease//HEAT repeat GO:0006508 proteolysis GO:0016740//GO:0008242//GO:0005515//GO:0004197 transferase activity//omega peptidase activity//protein binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.39964 BP_3 36.02 0.40 4621 189238710 XP_969341.2 3440 0.0e+00 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 642927019 XM_964248.3 155 1.44009e-72 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q86VQ3 216 1.1e-15 Thioredoxin domain-containing protein 2 OS=Homo sapiens GN=TXNDC2 PE=2 SV=4 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.39965 BP_3 19.09 1.02 1190 642918274 XP_008191440.1 1239 1.7e-133 PREDICTED: purine nucleoside phosphorylase isoform X1 [Tribolium castaneum] 327297537 XM_003233415.1 34 6.65728e-06 Trichophyton rubrum CBS 118892 purine nucleoside phosphorylase (TERG_06452) mRNA, complete cds K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P55859 815 9.9e-86 Purine nucleoside phosphorylase OS=Bos taurus GN=PNP PE=1 SV=3 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-8309.39966 BP_3 1505.26 9.21 8170 156481746 ABU68466.1 2057 1.6e-227 laccase 2 [Monochamus alternatus] 156481745 EU093075.1 794 0 Monochamus alternatus laccase 2 mRNA, complete cds -- -- -- -- Q99056 454 5.0e-43 Laccase-5 OS=Trametes villosa GN=LCC5 PE=3 SV=2 PF07731//PF07732//PF00394 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0005507//GO:0016491 copper ion binding//oxidoreductase activity -- -- KOG1263 Multicopper oxidases Cluster-8309.39968 BP_3 125.63 1.26 5099 589060796 AHK26791.1 193 1.4e-11 eukaryotic translation initiation factor 4A [Epicauta chinensis] -- -- -- -- -- K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 Q5R4X1 167 5.9e-10 Eukaryotic initiation factor 4A-II OS=Pongo abelii GN=EIF4A2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily Cluster-8309.39969 BP_3 1810.93 34.90 2793 642923048 XP_008200509.1 2851 0.0e+00 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923050|ref|XP_008200510.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923052|ref|XP_008200511.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJP5 1114 5.0e-120 Fibronectin type-III domain-containing protein 3a OS=Gallus gallus GN=FNDC3A PE=2 SV=2 PF16794//PF16656//PF00041 Fibronectin-III type domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.39970 BP_3 177.03 3.51 2726 642923048 XP_008200509.1 2162 3.5e-240 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923050|ref|XP_008200510.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923052|ref|XP_008200511.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJP5 1077 9.5e-116 Fibronectin type-III domain-containing protein 3a OS=Gallus gallus GN=FNDC3A PE=2 SV=2 PF16794//PF00041//PF16656 Fibronectin-III type domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.39971 BP_3 22.51 3.32 618 727098952 AIY54301.1 682 3.3e-69 ribosomal protein L32e [Colaphellus bowringi] 727098951 KJ534560.1 204 1.05873e-100 Colaphellus bowringi ribosomal protein L32e (RPL32e) mRNA, complete cds K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q8WRF3 637 2.2e-65 60S ribosomal protein L32 OS=Apis mellifera GN=RpL32 PE=2 SV=1 PF01655 Ribosomal protein L32 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0878 60S ribosomal protein L32 Cluster-8309.39972 BP_3 335.08 4.78 3672 642936428 XP_008198430.1 1462 7.1e-159 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.2171e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 532 2.0e-52 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.39973 BP_3 201.96 8.12 1491 270003289 EEZ99736.1 605 6.8e-60 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62101 128 5.7e-06 Serine/threonine-protein kinase D1 OS=Mus musculus GN=Prkd1 PE=1 SV=2 PF09202//PF00130 Rio2, N-terminal//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0009069//GO:0035556//GO:0006468//GO:0016310 serine family amino acid metabolic process//intracellular signal transduction//protein phosphorylation//phosphorylation GO:0005524//GO:0004674 ATP binding//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.39974 BP_3 1328.87 15.08 4538 123463203 XP_001316939.1 238 7.4e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121899660|gb|EAY04716.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 222 2.2e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF09174//PF04083 Maf1 regulator//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0016480 lipid metabolic process//negative regulation of transcription from RNA polymerase III promoter -- -- -- -- KOG4177 Ankyrin Cluster-8309.39975 BP_3 2449.15 18.32 6736 642912527 XP_008200900.1 856 2.4e-88 PREDICTED: zinc finger C4H2 domain-containing protein isoform X2 [Tribolium castaneum]>gi|270002588|gb|EEZ99035.1| hypothetical protein TcasGA2_TC004909 [Tribolium castaneum] 752869764 XM_011253703.1 73 8.06254e-27 PREDICTED: Camponotus floridanus zinc finger C4H2 domain-containing protein (LOC105248746), transcript variant X4, mRNA -- -- -- -- Q9NQZ6 443 7.7e-42 Zinc finger C4H2 domain-containing protein OS=Homo sapiens GN=ZC4H2 PE=1 SV=1 PF03854//PF02251//PF00769//PF03229 P-11 zinc finger//Proteasome activator pa28 alpha subunit//Ezrin/radixin/moesin family//Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process GO:0008270//GO:0003723//GO:0008092 zinc ion binding//RNA binding//cytoskeletal protein binding GO:0019898//GO:0008537//GO:0005737 extrinsic component of membrane//proteasome activator complex//cytoplasm -- -- Cluster-8309.39976 BP_3 2.00 0.74 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39978 BP_3 2986.86 28.20 5397 189237995 XP_001812873.1 4940 0.0e+00 PREDICTED: protein outspread [Tribolium castaneum] 642925058 XM_008195932.1 51 1.09541e-14 PREDICTED: Tribolium castaneum tectonin beta-propeller repeat-containing protein (LOC100141852), transcript variant X5, mRNA -- -- -- -- Q27421 628 2.2e-63 Protein outspread OS=Drosophila melanogaster GN=osp PE=2 SV=5 PF00367 phosphotransferase system, EIIB GO:0008643 carbohydrate transport GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex KOG4807 F-actin binding protein, regulates actin cytoskeletal organization Cluster-8309.39979 BP_3 21.03 0.40 2831 546674950 ERL86223.1 1942 1.2e-214 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 1.07311e-111 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1521 3.2e-167 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF03949//PF00390//PF08715 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain//Papain like viral protease GO:0055114//GO:0006108//GO:0015976//GO:0006099//GO:0006090//GO:0006508 oxidation-reduction process//malate metabolic process//carbon utilization//tricarboxylic acid cycle//pyruvate metabolic process//proteolysis GO:0004197//GO:0004471//GO:0051287//GO:0008242//GO:0016740 cysteine-type endopeptidase activity//malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding//omega peptidase activity//transferase activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.39980 BP_3 353.79 9.10 2166 478253499 ENN73826.1 1562 1.1e-170 hypothetical protein YQE_09604, partial [Dendroctonus ponderosae] 195146567 XM_002014220.1 155 6.69529e-73 Drosophila persimilis gpdh (Dper\Gpdh), mRNA K00006 GPD1 glycerol-3-phosphate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00006 P13706 1395 1.0e-152 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Drosophila melanogaster GN=Gpdh PE=1 SV=3 PF07479//PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GO:0046168//GO:0006072//GO:0005975//GO:0046486//GO:0055114 glycerol-3-phosphate catabolic process//glycerol-3-phosphate metabolic process//carbohydrate metabolic process//glycerolipid metabolic process//oxidation-reduction process GO:0016616//GO:0051287//GO:0004367 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//glycerol-3-phosphate dehydrogenase [NAD+] activity GO:0009331 glycerol-3-phosphate dehydrogenase complex KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase Cluster-8309.39983 BP_3 45.76 0.62 3827 91088677 XP_974860.1 748 4.6e-76 PREDICTED: probable aconitate hydratase, mitochondrial [Tribolium castaneum]>gi|270011673|gb|EFA08121.1| hypothetical protein TcasGA2_TC005725 [Tribolium castaneum] 743728916 XM_010960233.1 74 1.26898e-27 PREDICTED: Camelus bactrianus aconitase 2, mitochondrial (ACO2), mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 P20004 648 7.4e-66 Aconitate hydratase, mitochondrial OS=Bos taurus GN=ACO2 PE=1 SV=4 PF00694 Aconitase C-terminal domain GO:0019643//GO:0046487//GO:0006099//GO:0008152 reductive tricarboxylic acid cycle//glyoxylate metabolic process//tricarboxylic acid cycle//metabolic process GO:0051539//GO:0003994 4 iron, 4 sulfur cluster binding//aconitate hydratase activity -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.39986 BP_3 146.94 2.47 3160 642927886 XP_001813556.2 1242 2.0e-133 PREDICTED: follistatin [Tribolium castaneum] -- -- -- -- -- K04661 FST follistatin http://www.genome.jp/dbget-bin/www_bget?ko:K04661 P31514 643 2.3e-65 Follistatin (Fragment) OS=Ovis aries GN=FST PE=2 SV=1 PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.39987 BP_3 112.37 1.83 3252 642931697 XP_008196692.1 1943 1.0e-214 PREDICTED: uncharacterized protein LOC657740 isoform X1 [Tribolium castaneum]>gi|270012781|gb|EFA09229.1| stem cell tumour protein [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 576 1.4e-57 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF13499//PF13405//PF00036//PF01694 EF-hand domain pair//EF-hand domain//EF hand//Rhomboid family GO:0006508 proteolysis GO:0004252//GO:0005509 serine-type endopeptidase activity//calcium ion binding GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.39990 BP_3 234.69 4.01 3116 642938354 XP_008198798.1 565 6.2e-55 PREDICTED: peptidyl-prolyl cis-trans isomerase G [Tribolium castaneum] 645259408 XM_008237125.1 62 4.83076e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 A2AR02 448 9.4e-43 Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus GN=Ppig PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.39992 BP_3 84.22 2.21 2132 642930848 XP_008196112.1 309 2.0e-25 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39993 BP_3 227.40 1.22 9258 642930846 XP_008196111.1 677 1.9e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39995 BP_3 140.07 1.92 3810 478256345 ENN76535.1 247 5.7e-18 hypothetical protein YQE_06986, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04623//PF01442//PF07464 Adenovirus E1B protein N-terminus//Apolipoprotein A1/A4/E domain//Apolipophorin-III precursor (apoLp-III) GO:0006869//GO:0009605//GO:0042157 lipid transport//response to external stimulus//lipoprotein metabolic process GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.39996 BP_3 265.41 1.67 7951 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 201 6.66884e-98 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF05680//PF00637//PF01165//PF13639//PF12861//PF00569//PF00443//PF14634//PF02723//PF02148//PF12678//PF17122//PF00097 ATP synthase E chain//Region in Clathrin and VPS//Ribosomal protein S21//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, ZZ type//Ubiquitin carboxyl-terminal hydrolase//zinc-RING finger domain//Non-structural protein NS3/Small envelope protein E//Zn-finger in ubiquitin-hydrolases and other protein//RING-H2 zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger) GO:0016579//GO:0015992//GO:0042254//GO:0006886//GO:0016192//GO:0015986//GO:0006412//GO:0016567 protein deubiquitination//proton transport//ribosome biogenesis//intracellular protein transport//vesicle-mediated transport//ATP synthesis coupled proton transport//translation//protein ubiquitination GO:0015078//GO:0003735//GO:0008270//GO:0036459//GO:0046872//GO:0005515//GO:0004842 hydrogen ion transmembrane transporter activity//structural constituent of ribosome//zinc ion binding//ubiquitinyl hydrolase activity//metal ion binding//protein binding//ubiquitin-protein transferase activity GO:0005840//GO:0016020//GO:0000276//GO:0005680 ribosome//membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//anaphase-promoting complex KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.39997 BP_3 853.81 8.15 5340 642930363 XP_008196367.1 971 8.8e-102 PREDICTED: protein DEK isoform X3 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.76244e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.39998 BP_3 8549.21 89.73 4884 642930363 XP_008196367.1 908 1.6e-94 PREDICTED: protein DEK isoform X3 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.43897e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P55828 475 1.1e-45 40S ribosomal protein S20 OS=Drosophila melanogaster GN=RpS20 PE=1 SV=1 PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.39999 BP_3 21.00 4.23 531 642930421 XP_008196394.1 389 2.7e-35 PREDICTED: tyrosine-protein kinase hopscotch [Tribolium castaneum] -- -- -- -- -- K04447 JAK2 Janus kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4 BP_3 68.00 4.62 1001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40 BP_3 31.00 0.86 2020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40001 BP_3 123.00 0.88 7011 642926249 XP_974073.3 1626 1.3e-177 PREDICTED: mannose-1-phosphate guanyltransferase beta [Tribolium castaneum]>gi|270009027|gb|EFA05475.1| hypothetical protein TcasGA2_TC015659 [Tribolium castaneum] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q295Y7 1534 2.5e-168 Mannose-1-phosphate guanyltransferase beta OS=Drosophila pseudoobscura pseudoobscura GN=GA10892 PE=3 SV=1 PF09270//PF01128//PF02932//PF08671//PF00483//PF06459//PF07959//PF00076 Beta-trefoil DNA-binding domain//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//Neurotransmitter-gated ion-channel transmembrane region//Anti-repressor SinI//Nucleotidyl transferase//Ryanodine Receptor TM 4-6//L-fucokinase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006811//GO:0006355//GO:0006694//GO:0009058//GO:0006874//GO:0006816//GO:0008299 ion transport//regulation of transcription, DNA-templated//steroid biosynthetic process//biosynthetic process//cellular calcium ion homeostasis//calcium ion transport//isoprenoid biosynthetic process GO:0003676//GO:0046983//GO:0005219//GO:0000982//GO:0016772//GO:0016779//GO:0000978//GO:0050518 nucleic acid binding//protein dimerization activity//ryanodine-sensitive calcium-release channel activity//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//transferase activity, transferring phosphorus-containing groups//nucleotidyltransferase activity//RNA polymerase II core promoter proximal region sequence-specific DNA binding//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity GO:0016020//GO:0005634//GO:0005622//GO:0016021 membrane//nucleus//intracellular//integral component of membrane KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.40003 BP_3 16.87 0.50 1919 91076404 XP_969308.1 1674 9.6e-184 PREDICTED: protein RMD5 homolog A [Tribolium castaneum]>gi|270002561|gb|EEZ99008.1| hypothetical protein TcasGA2_TC004876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80YQ8 1070 4.3e-115 Protein RMD5 homolog A OS=Mus musculus GN=Rmnd5a PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2817 Predicted E3 ubiquitin ligase Cluster-8309.40004 BP_3 37.72 0.37 5237 642911723 XP_008200714.1 359 8.0e-31 PREDICTED: scaffold attachment factor B2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80YR5 202 5.3e-14 Scaffold attachment factor B2 OS=Mus musculus GN=Safb2 PE=2 SV=2 PF09270//PF04111//PF06459//PF02932//PF00076 Beta-trefoil DNA-binding domain//Autophagy protein Apg6//Ryanodine Receptor TM 4-6//Neurotransmitter-gated ion-channel transmembrane region//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006816//GO:0006914//GO:0006355//GO:0006874//GO:0006811 calcium ion transport//autophagy//regulation of transcription, DNA-templated//cellular calcium ion homeostasis//ion transport GO:0005219//GO:0000982//GO:0003676//GO:0000978 ryanodine-sensitive calcium-release channel activity//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//nucleic acid binding//RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0005634//GO:0016021//GO:0005622//GO:0016020 nucleus//integral component of membrane//intracellular//membrane -- -- Cluster-8309.40005 BP_3 3601.47 55.33 3429 478256345 ENN76535.1 247 5.1e-18 hypothetical protein YQE_06986, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07464//PF01442//PF04623 Apolipophorin-III precursor (apoLp-III)//Apolipoprotein A1/A4/E domain//Adenovirus E1B protein N-terminus GO:0042157//GO:0009605//GO:0006869 lipoprotein metabolic process//response to external stimulus//lipid transport GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.40007 BP_3 292.29 6.92 2327 91078348 XP_973652.1 1386 2.9e-150 PREDICTED: prostaglandin E synthase 2 [Tribolium castaneum]>gi|270003893|gb|EFA00341.1| hypothetical protein TcasGA2_TC003180 [Tribolium castaneum] -- -- -- -- -- K05309 PTGES2 microsomal prostaglandin-E synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05309 Q9N0A4 674 4.4e-69 Prostaglandin E synthase 2 OS=Macaca fascicularis GN=PTGES2 PE=1 SV=1 PF02798//PF00462//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0009055//GO:0015035//GO:0005515 electron carrier activity//protein disulfide oxidoreductase activity//protein binding -- -- KOG3029 Glutathione S-transferase-related protein Cluster-8309.40008 BP_3 3145.89 26.46 6023 546682084 ERL92070.1 2226 3.0e-247 hypothetical protein D910_09392, partial [Dendroctonus ponderosae] 755993244 XM_011315162.1 85 1.53831e-33 PREDICTED: Fopius arisanus inorganic pyrophosphatase (LOC105272929), mRNA K09583 PDIA5 protein disulfide isomerase family A, member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09583 Q5I0H9 1046 8.2e-112 Protein disulfide-isomerase A5 OS=Rattus norvegicus GN=Pdia5 PE=2 SV=1 PF00719//PF00085//PF08534//PF07689//PF00462//PF00578//PF01323 Inorganic pyrophosphatase//Thioredoxin//Redoxin//KaiB domain//Glutaredoxin//AhpC/TSA family//DSBA-like thioredoxin domain GO:0006796//GO:0006119//GO:0048511//GO:0045454//GO:0055114//GO:0006118 phosphate-containing compound metabolic process//oxidative phosphorylation//rhythmic process//cell redox homeostasis//oxidation-reduction process//obsolete electron transport GO:0016491//GO:0004427//GO:0000287//GO:0015035//GO:0016209//GO:0009055 oxidoreductase activity//inorganic diphosphatase activity//magnesium ion binding//protein disulfide oxidoreductase activity//antioxidant activity//electron carrier activity GO:0005737 cytoplasm KOG1626 Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 Cluster-8309.40009 BP_3 59.62 0.50 6083 546682084 ERL92070.1 2226 3.0e-247 hypothetical protein D910_09392, partial [Dendroctonus ponderosae] 755993244 XM_011315162.1 85 1.55373e-33 PREDICTED: Fopius arisanus inorganic pyrophosphatase (LOC105272929), mRNA K09583 PDIA5 protein disulfide isomerase family A, member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09583 Q5I0H9 1046 8.3e-112 Protein disulfide-isomerase A5 OS=Rattus norvegicus GN=Pdia5 PE=2 SV=1 PF08534//PF00719//PF00085//PF07689//PF00578//PF00462//PF01323 Redoxin//Inorganic pyrophosphatase//Thioredoxin//KaiB domain//AhpC/TSA family//Glutaredoxin//DSBA-like thioredoxin domain GO:0048511//GO:0006796//GO:0006119//GO:0006118//GO:0055114//GO:0045454 rhythmic process//phosphate-containing compound metabolic process//oxidative phosphorylation//obsolete electron transport//oxidation-reduction process//cell redox homeostasis GO:0004427//GO:0016491//GO:0016209//GO:0015035//GO:0009055//GO:0000287 inorganic diphosphatase activity//oxidoreductase activity//antioxidant activity//protein disulfide oxidoreductase activity//electron carrier activity//magnesium ion binding GO:0005737 cytoplasm KOG1626 Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 Cluster-8309.40012 BP_3 405.50 4.47 4666 642922644 XP_971277.2 3230 0.0e+00 PREDICTED: zinc finger protein ush isoform X2 [Tribolium castaneum] 642922643 XM_966184.2 48 4.40152e-13 PREDICTED: Tribolium castaneum zinc finger protein u-shaped (LOC659918), transcript variant X2, mRNA K17441 ZFPM1, FOG1 zinc finger protein ZFPM1 http://www.genome.jp/dbget-bin/www_bget?ko:K17441 Q9VPQ6 831 5.4e-87 Zinc finger protein ush OS=Drosophila melanogaster GN=ush PE=1 SV=2 PF05221//PF16622//PF13465//PF00096 S-adenosyl-L-homocysteine hydrolase//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006555//GO:0006730 methionine metabolic process//one-carbon metabolic process GO:0046872//GO:0004013 metal ion binding//adenosylhomocysteinase activity -- -- -- -- Cluster-8309.40014 BP_3 14.39 0.42 1947 332376933 AEE63606.1 1163 1.8e-124 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 Q01604 1026 5.6e-110 Phosphoglycerate kinase OS=Drosophila melanogaster GN=Pgk PE=2 SV=2 PF00162 Phosphoglycerate kinase GO:0006094//GO:0006096//GO:0015976//GO:0016310 gluconeogenesis//glycolytic process//carbon utilization//phosphorylation GO:0004618 phosphoglycerate kinase activity -- -- KOG1367 3-phosphoglycerate kinase Cluster-8309.40015 BP_3 2135.12 41.66 2762 91081249 XP_975650.1 644 3.8e-64 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q5ZKN2 382 3.7e-35 Membrane-associated progesterone receptor component 1 OS=Gallus gallus GN=PGRMC1 PE=2 SV=3 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.40016 BP_3 2053.54 69.01 1726 576251521 AHH29345.1 835 1.7e-86 vacuolar H[+]-ATPase E subunit [Leptinotarsa decemlineata] 195389988 XM_002053615.1 144 6.92143e-67 Drosophila virilis GJ23234 (Dvir\GJ23234), mRNA K02150 ATPeV1E, ATP6E V-type H+-transporting ATPase subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K02150 P31402 639 3.7e-65 V-type proton ATPase subunit E OS=Manduca sexta GN=VHA26 PE=2 SV=1 PF01481//PF00191//PF01991 Arterivirus nucleocapsid protein//Annexin//ATP synthase (E/31 kDa) subunit GO:0006119//GO:0015991//GO:0015992 oxidative phosphorylation//ATP hydrolysis coupled proton transport//proton transport GO:0005544//GO:0046961//GO:0005509 calcium-dependent phospholipid binding//proton-transporting ATPase activity, rotational mechanism//calcium ion binding GO:0033178//GO:0019013 proton-transporting two-sector ATPase complex, catalytic domain//viral nucleocapsid KOG1664 Vacuolar H+-ATPase V1 sector, subunit E Cluster-8309.40019 BP_3 793.51 12.66 3313 91078322 XP_972953.1 981 3.8e-103 PREDICTED: pyridoxal kinase [Tribolium castaneum]>gi|270003960|gb|EFA00408.1| hypothetical protein TcasGA2_TC003259 [Tribolium castaneum] -- -- -- -- -- K00868 pdxK, pdxY pyridoxine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00868 O00764 739 1.8e-76 Pyridoxal kinase OS=Homo sapiens GN=PDXK PE=1 SV=1 PF08656//PF07716//PF00170 DASH complex subunit Dad3//Basic region leucine zipper//bZIP transcription factor GO:0042816//GO:0009443//GO:0008608//GO:0006355 vitamin B6 metabolic process//pyridoxal 5'-phosphate salvage//attachment of spindle microtubules to kinetochore//regulation of transcription, DNA-templated GO:0008478//GO:0003700//GO:0043565 pyridoxal kinase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0072686//GO:0042729 transcription factor complex//mitotic spindle//DASH complex KOG2599 Pyridoxal/pyridoxine/pyridoxamine kinase Cluster-8309.4002 BP_3 2.00 0.96 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40021 BP_3 39.39 0.38 5257 642912009 XP_008199058.1 1160 1.1e-123 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X1 [Tribolium castaneum]>gi|270014484|gb|EFA10932.1| hypothetical protein TcasGA2_TC001759 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40022 BP_3 9.84 0.31 1798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40023 BP_3 78.93 0.74 5414 642912011 XP_008199059.1 1160 1.1e-123 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05373//PF02892 L-proline 3-hydroxylase, C-terminal//BED zinc finger GO:0055114 oxidation-reduction process GO:0003677//GO:0016706 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.40024 BP_3 359.74 6.64 2903 332373440 AEE61861.1 1517 2.3e-165 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RDN7 1071 5.0e-115 Carboxypeptidase Q OS=Pongo abelii GN=CPQ PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2195 Transferrin receptor and related proteins containing the protease-associated (PA) domain Cluster-8309.40025 BP_3 1932.82 26.72 3778 91083579 XP_968212.1 2350 7.8e-262 PREDICTED: lysine--tRNA ligase isoform X2 [Tribolium castaneum]>gi|270007824|gb|EFA04272.1| hypothetical protein TcasGA2_TC014562 [Tribolium castaneum] 157106532 XM_001649316.1 207 1.45718e-101 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1951 5.9e-217 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF01336//PF01409//PF00152//PF17121 OB-fold nucleic acid binding domain//tRNA synthetases class II core domain (F)//tRNA synthetases class II (D, K and N)//Zinc finger, C3HC4 type (RING finger) GO:0009085//GO:0006430//GO:0043039//GO:0006418 lysine biosynthetic process//lysyl-tRNA aminoacylation//tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0005515//GO:0000049//GO:0004824//GO:0005524//GO:0004812//GO:0003676//GO:0000166//GO:0008270 protein binding//tRNA binding//lysine-tRNA ligase activity//ATP binding//aminoacyl-tRNA ligase activity//nucleic acid binding//nucleotide binding//zinc ion binding GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.40026 BP_3 430.71 8.55 2719 91085939 XP_970530.1 645 2.8e-64 PREDICTED: longitudinals lacking protein-like [Tribolium castaneum]>gi|270010169|gb|EFA06617.1| hypothetical protein TcasGA2_TC009535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KRI2 601 1.5e-60 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40027 BP_3 1026.42 10.02 5231 91090858 XP_967143.1 1197 5.4e-128 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] 688710729 LL320824.1 36 2.31404e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0001563 K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 898 1.0e-94 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191//PF01580//PF00270//PF04851//PF02562//PF00580//PF06733 Annexin//FtsK/SpoIIIE family//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//PhoH-like protein//UvrD/REP helicase N-terminal domain//DEAD_2 -- -- GO:0004003//GO:0003676//GO:0005509//GO:0000166//GO:0005544//GO:0003677//GO:0016787//GO:0005524 ATP-dependent DNA helicase activity//nucleic acid binding//calcium ion binding//nucleotide binding//calcium-dependent phospholipid binding//DNA binding//hydrolase activity//ATP binding GO:0005657 replication fork KOG0819 Annexin Cluster-8309.40028 BP_3 2330.30 74.82 1793 642936042 XP_008198279.1 1235 7.2e-133 PREDICTED: annexin B9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 905 5.5e-96 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191 Annexin -- -- GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding -- -- KOG0819 Annexin Cluster-8309.40029 BP_3 77.74 6.42 875 665792068 XP_008543619.1 219 2.3e-15 PREDICTED: zinc finger protein 888-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P17010 167 1.0e-10 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.4003 BP_3 8.00 0.39 1277 642925409 XP_008194539.1 983 8.6e-104 PREDICTED: anoctamin-4-like [Tribolium castaneum]>gi|270008794|gb|EFA05242.1| hypothetical protein TcasGA2_TC015391 [Tribolium castaneum] -- -- -- -- -- K19499 ANO4, TMEM16D anoctamin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K19499 Q32M45 530 1.2e-52 Anoctamin-4 OS=Homo sapiens GN=ANO4 PE=2 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0006820//GO:0006821 anion transport//chloride transport GO:0046983//GO:0005254 protein dimerization activity//chloride channel activity GO:0034707 chloride channel complex KOG2514 Uncharacterized conserved protein Cluster-8309.40032 BP_3 456.59 8.89 2767 91084963 XP_971862.1 1796 9.9e-198 PREDICTED: GPI mannosyltransferase 4 [Tribolium castaneum]>gi|270009003|gb|EFA05451.1| hypothetical protein TcasGA2_TC015632 [Tribolium castaneum] -- -- -- -- -- K08098 PIGZ, SMP3 phosphatidylinositol glycan, class Z http://www.genome.jp/dbget-bin/www_bget?ko:K08098 Q8MT80 1131 5.3e-122 GPI mannosyltransferase 4 OS=Drosophila melanogaster GN=CG45068 PE=2 SV=1 PF03901//PF04428//PF06703 Alg9-like mannosyltransferase family//Choline kinase N terminus//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233//GO:0016773//GO:0016757 peptidase activity//phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring glycosyl groups GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane KOG4123 Putative alpha 1,2 mannosyltransferase Cluster-8309.40033 BP_3 484.85 4.71 5249 189239140 XP_001806913.1 1410 1.1e-152 PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|642928372|ref|XP_008192716.1| PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|270010787|gb|EFA07235.1| hypothetical protein TcasGA2_TC010592 [Tribolium castaneum] 657809175 XM_008333639.1 51 1.06517e-14 PREDICTED: Cynoglossus semilaevis TSC22 domain family protein 2-like (LOC103395840), transcript variant X2, mRNA -- -- -- -- Q24523 204 3.1e-14 Protein bunched, class 2/F/G isoform OS=Drosophila melanogaster GN=bun PE=2 SV=4 PF00170//PF06005//PF04977//PF06156//PF01486//PF11365//PF07716//PF00038//PF01166//PF07926//PF04799 bZIP transcription factor//Protein of unknown function (DUF904)//Septum formation initiator//Protein of unknown function (DUF972)//K-box region//Protein of unknown function (DUF3166)//Basic region leucine zipper//Intermediate filament protein//TSC-22/dip/bun family//TPR/MLP1/MLP2-like protein//fzo-like conserved region GO:0010506//GO:0007049//GO:0006606//GO:0006355//GO:0006260//GO:0000917//GO:0043093//GO:0008053 regulation of autophagy//cell cycle//protein import into nucleus//regulation of transcription, DNA-templated//DNA replication//barrier septum assembly//FtsZ-dependent cytokinesis//mitochondrial fusion GO:0005198//GO:0003924//GO:0003700//GO:0043565 structural molecule activity//GTPase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005882//GO:0016021//GO:0005615//GO:0005737//GO:0005667//GO:0005634//GO:0005741 intermediate filament//integral component of membrane//extracellular space//cytoplasm//transcription factor complex//nucleus//mitochondrial outer membrane KOG4797 Transcriptional regulator Cluster-8309.40034 BP_3 163.00 9.65 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00424 REV protein (anti-repression trans-activator protein) GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0042025 transcription factor complex//host cell nucleus -- -- Cluster-8309.40035 BP_3 47.45 0.47 5127 546674614 ERL85963.1 525 4.4e-50 hypothetical protein D910_03378 [Dendroctonus ponderosae] 597798758 XM_007260859.1 49 1.34564e-13 PREDICTED: Astyanax mexicanus superoxide dismutase 2, mitochondrial (sod2), mRNA K04564 SOD2 superoxide dismutase, Fe-Mn family http://www.genome.jp/dbget-bin/www_bget?ko:K04564 O96347 458 1.1e-43 Superoxide dismutase [Mn], mitochondrial OS=Charybdis feriata PE=2 SV=1 PF00081//PF16672//PF04506//PF02285//PF02777 Iron/manganese superoxide dismutases, alpha-hairpin domain//Ragulator complex protein LAMTOR5//Rft protein//Cytochrome oxidase c subunit VIII//Iron/manganese superoxide dismutases, C-terminal domain GO:0006801//GO:0043154//GO:0006869//GO:0043066//GO:0055114//GO:0015992//GO:0019079//GO:0006123 superoxide metabolic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//lipid transport//negative regulation of apoptotic process//oxidation-reduction process//proton transport//viral genome replication//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0046872//GO:0005319//GO:0004784 cytochrome-c oxidase activity//metal ion binding//lipid transporter activity//superoxide dismutase activity GO:0071986//GO:0045277//GO:0005737//GO:0016021 Ragulator complex//respiratory chain complex IV//cytoplasm//integral component of membrane KOG0876 Manganese superoxide dismutase Cluster-8309.40036 BP_3 425.24 16.95 1501 332376807 AEE63543.1 1800 1.9e-198 unknown [Dendroctonus ponderosae] 645003053 XM_008209892.1 41 1.08535e-09 PREDICTED: Nasonia vitripennis kynurenine--oxoglutarate transaminase 3-like (LOC100119206), mRNA K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 1245 1.7e-135 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF00155//PF01053 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.40038 BP_3 211.88 1.75 6117 546670634 ERL83320.1 5513 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.47037e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q8NFA0 1141 8.1e-123 Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens GN=USP32 PE=1 SV=1 PF13499//PF06337//PF05191//PF13405//PF00036//PF00443//PF11421 EF-hand domain pair//DUSP domain//Adenylate kinase, active site lid//EF-hand domain//EF hand//Ubiquitin carboxyl-terminal hydrolase//ATP synthase F1 beta subunit GO:0006144//GO:0046034//GO:0006508//GO:0006754//GO:0016579 purine nucleobase metabolic process//ATP metabolic process//proteolysis//ATP biosynthetic process//protein deubiquitination GO:0005524//GO:0036459//GO:0004843//GO:0005509//GO:0016887//GO:0004017 ATP binding//ubiquitinyl hydrolase activity//ubiquitin-specific protease activity//calcium ion binding//ATPase activity//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.40040 BP_3 481.79 11.27 2353 270010227 EFA06675.1 1693 7.4e-186 hypothetical protein TcasGA2_TC009605 [Tribolium castaneum] -- -- -- -- -- K06776 PTPRK receptor-type tyrosine-protein phosphatase kappa http://www.genome.jp/dbget-bin/www_bget?ko:K06776 Q15262 809 9.8e-85 Receptor-type tyrosine-protein phosphatase kappa OS=Homo sapiens GN=PTPRK PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.40042 BP_3 49.56 0.41 6091 642927862 XP_008195429.1 2591 1.4e-289 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X2 [Tribolium castaneum]>gi|270009857|gb|EFA06305.1| hypothetical protein TcasGA2_TC009173 [Tribolium castaneum] 662183442 XM_008489250.1 153 2.46013e-71 PREDICTED: Diaphorina citri receptor-type tyrosine-protein phosphatase alpha (LOC103524239), mRNA -- -- -- -- P35822 833 4.2e-87 Receptor-type tyrosine-protein phosphatase kappa OS=Mus musculus GN=Ptprk PE=1 SV=1 PF00641//PF00782//PF00041//PF00102//PF07973 Zn-finger in Ran binding protein and others//Dual specificity phosphatase, catalytic domain//Fibronectin type III domain//Protein-tyrosine phosphatase//Threonyl and Alanyl tRNA synthetase second additional domain GO:0006570//GO:0006470//GO:0035335//GO:0043039 tyrosine metabolic process//protein dephosphorylation//peptidyl-tyrosine dephosphorylation//tRNA aminoacylation GO:0004725//GO:0005515//GO:0008138//GO:0005524//GO:0016876//GO:0008270 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//zinc ion binding -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.40044 BP_3 17.29 0.57 1758 642918287 XP_008191445.1 374 4.9e-33 PREDICTED: uncharacterized protein LOC655985 isoform X1 [Tribolium castaneum]>gi|270003276|gb|EEZ99723.1| hypothetical protein TcasGA2_TC002488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4VYA5 146 5.5e-08 5-hydroxyisourate hydrolase OS=Salmonella dublin GN=hiuH PE=1 SV=1 PF01060 Transthyretin-like family GO:0006144//GO:0006810 purine nucleobase metabolic process//transport GO:0033971 hydroxyisourate hydrolase activity GO:0005615 extracellular space -- -- Cluster-8309.40045 BP_3 106.79 1.33 4172 642936134 XP_008198313.1 3421 0.0e+00 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 723 0 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q8T674 926 4.7e-98 ABC transporter G family member 20 OS=Dictyostelium discoideum GN=abcG20 PE=3 SV=1 PF03193//PF00005//PF13304//PF01061 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC-2 type transporter -- -- GO:0005524//GO:0005525//GO:0016887//GO:0003924 ATP binding//GTP binding//ATPase activity//GTPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.40046 BP_3 43.00 0.55 4027 642936656 XP_008198526.1 439 3.3e-40 PREDICTED: LOW QUALITY PROTEIN: probable nuclear transport factor 2 [Tribolium castaneum] 501296900 AK417836.1 93 3.66219e-38 Riptortus pedestris mRNA for conserved hypothetical protein, complete cds, sequence id: Rped-1207 -- -- -- -- Q21735 222 1.9e-16 Probable nuclear transport factor 2 OS=Caenorhabditis elegans GN=ran-4 PE=3 SV=1 PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular KOG2104 Nuclear transport factor 2 Cluster-8309.40049 BP_3 126.02 1.69 3882 91078854 XP_971956.1 810 3.0e-83 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit C [Tribolium castaneum]>gi|270004131|gb|EFA00579.1| hypothetical protein TcasGA2_TC003449 [Tribolium castaneum] 242023017 XM_002431888.1 35 6.16157e-06 Pediculus humanus corporis Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative, mRNA K03859 PIGC, GPI2 phosphatidylinositol glycan, class C http://www.genome.jp/dbget-bin/www_bget?ko:K03859 Q92535 456 1.4e-43 Phosphatidylinositol N-acetylglucosaminyltransferase subunit C OS=Homo sapiens GN=PIGC PE=2 SV=1 PF01158//PF06432 Ribosomal protein L36e//Phosphatidylinositol N-acetylglucosaminyltransferase GO:0006506//GO:0042254//GO:0006412 GPI anchor biosynthetic process//ribosome biogenesis//translation GO:0003735//GO:0017176 structural constituent of ribosome//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG3452 60S ribosomal protein L36 Cluster-8309.40050 BP_3 391.83 26.15 1014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40051 BP_3 423.52 18.24 1411 642918470 XP_008191489.1 1818 1.4e-200 PREDICTED: protein NDRG3 isoform X2 [Tribolium castaneum] 462464055 APGK01005064.1 69 2.77294e-25 Dendroctonus ponderosae Seq01005066, whole genome shotgun sequence -- -- -- -- Q5RA95 642 1.4e-65 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.40053 BP_3 1900.06 38.31 2682 546676376 ERL87398.1 1107 7.5e-118 hypothetical protein D910_04793, partial [Dendroctonus ponderosae] -- -- -- -- -- K13212 LUC7L2 RNA-binding protein Luc7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13212 Q9Y383 866 2.7e-91 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens GN=LUC7L2 PE=1 SV=2 PF03194//PF00472 LUC7 N_terminus//RF-1 domain GO:0006449//GO:0006376//GO:0006415 regulation of translational termination//mRNA splice site selection//translational termination GO:0003747//GO:0003729 translation release factor activity//mRNA binding GO:0005685//GO:0018444//GO:0005840 U1 snRNP//translation release factor complex//ribosome KOG0796 Spliceosome subunit Cluster-8309.40054 BP_3 1042.84 12.48 4320 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 2.9962e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 1.0e-26 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF13855//PF13895//PF03526//PF00560 Leucine rich repeat//Immunoglobulin domain//Colicin E1 (microcin) immunity protein//Leucine Rich Repeat GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0005515//GO:0015643 protein binding//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.40055 BP_3 879.77 18.27 2613 478254653 ENN74894.1 504 6.1e-48 hypothetical protein YQE_08473, partial [Dendroctonus ponderosae]>gi|546676113|gb|ERL87180.1| hypothetical protein D910_04580 [Dendroctonus ponderosae] 291062114 GQ923775.1 67 6.72046e-24 Macrobrachium nipponense ubiquitin-conjugating enzyme (Ubc9) mRNA, complete cds K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 O09181 455 1.2e-43 SUMO-conjugating enzyme UBC9 OS=Mesocricetus auratus GN=UBE2I PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.40056 BP_3 2537.66 161.95 1047 91078958 XP_974220.1 800 1.2e-82 PREDICTED: cathepsin B [Tribolium castaneum]>gi|642916227|ref|XP_008190938.1| PREDICTED: cathepsin B [Tribolium castaneum]>gi|270004841|gb|EFA01289.1| cathepsin B precursor [Tribolium castaneum] 642916228 XM_969127.2 140 6.94042e-65 PREDICTED: Tribolium castaneum cathepsin B precursor (LOC663066), transcript variant X2, mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07858 618 6.1e-63 Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 PF08127//PF00112 Peptidase family C1 propeptide//Papain family cysteine protease GO:0050790//GO:0006508 regulation of catalytic activity//proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.40058 BP_3 4922.43 103.23 2590 546683392 ERL93211.1 2655 2.3e-297 hypothetical protein D910_10507, partial [Dendroctonus ponderosae] 642936324 XM_008200175.1 104 1.8002e-44 PREDICTED: Tribolium castaneum integrin beta-PS (LOC657674), transcript variant X2, mRNA K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 2154 1.2e-240 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.40060 BP_3 291.39 5.49 2851 642928048 XP_008200135.1 946 3.7e-99 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 255 2.1e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF09392//PF05104//PF04508 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Ribosome receptor lysine/proline rich region//Viral A-type inclusion protein repeat GO:0015031//GO:0016032//GO:0009405 protein transport//viral process//pathogenesis -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.40061 BP_3 266.87 2.53 5369 255958217 NP_001157690.1 511 1.9e-48 fruitless [Tribolium castaneum]>gi|642913400|ref|XP_008200994.1| PREDICTED: fruitless isoform X1 [Tribolium castaneum]>gi|379324165|gb|AFD01647.1| fruitless zinc-finger B isoform [Tribolium castaneum] 642913399 XM_008202772.1 149 3.62579e-69 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X3, mRNA -- -- -- -- Q8IN81 143 3.8e-07 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF13912//PF01363//PF02892//PF01943//PF00096//PF13465 C2H2-type zinc finger//FYVE zinc finger//BED zinc finger//Polysaccharide biosynthesis protein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0000271 polysaccharide biosynthetic process GO:0046872//GO:0008270//GO:0003676//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//DNA binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.40062 BP_3 91.71 2.02 2483 642913408 XP_008200998.1 1302 1.7e-140 PREDICTED: fruitless isoform X7 [Tribolium castaneum] 642913407 XM_008202776.1 251 3.31048e-126 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X7, mRNA -- -- -- -- Q8IN81 552 6.5e-55 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF02892//PF00651//PF00096 BED zinc finger//BTB/POZ domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872//GO:0005515 DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.40063 BP_3 115.61 0.99 5902 642915710 XP_008190770.1 2335 6.7e-260 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.9e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF00621//PF01920 RhoGEF domain//Prefoldin subunit GO:0006457//GO:0043087//GO:0035023 protein folding//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089//GO:0051082 Rho guanyl-nucleotide exchange factor activity//unfolded protein binding GO:0016272 prefoldin complex KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.40064 BP_3 385.02 3.59 5456 189237561 XP_974680.2 988 9.7e-104 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 1.2e-56 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.40065 BP_3 643.32 5.30 6144 642915710 XP_008190770.1 4183 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X1 [Tribolium castaneum] 752876735 XM_011257478.1 63 2.66359e-21 PREDICTED: Camponotus floridanus rho guanine nucleotide exchange factor 12 (LOC105251006), transcript variant X6, mRNA K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 2.0e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF00595//PF00621//PF13180//PF00130//PF09128 PDZ domain (Also known as DHR or GLGF)//RhoGEF domain//PDZ domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Regulator of G protein signalling-like domain GO:0035556//GO:0035023//GO:0043087 intracellular signal transduction//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding GO:0005737 cytoplasm KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.40068 BP_3 32.17 1.05 1775 478255819 ENN76027.1 855 8.3e-89 hypothetical protein YQE_07403, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.40069 BP_3 40.33 1.23 1876 332376523 AEE63401.1 1339 6.6e-145 unknown [Dendroctonus ponderosae]>gi|478249799|gb|ENN70306.1| hypothetical protein YQE_12817, partial [Dendroctonus ponderosae]>gi|546682880|gb|ERL92766.1| hypothetical protein D910_10075 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38942 735 3.0e-76 4-hydroxybutyrate coenzyme A transferase OS=Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) GN=cat2 PE=3 SV=3 PF02550 Acetyl-CoA hydrolase/transferase N-terminal domain GO:0006084 acetyl-CoA metabolic process GO:0003824 catalytic activity -- -- KOG2828 Acetyl-CoA hydrolase Cluster-8309.40070 BP_3 281.81 2.81 5130 91084663 XP_967750.1 2228 1.5e-247 PREDICTED: ubiquitin carboxyl-terminal hydrolase 4 isoform X1 [Tribolium castaneum]>gi|270008628|gb|EFA05076.1| hypothetical protein TcasGA2_TC015173 [Tribolium castaneum] 698430595 XM_009698856.1 46 6.26433e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K11833 USP2_21 ubiquitin carboxyl-terminal hydrolase 2/21 http://www.genome.jp/dbget-bin/www_bget?ko:K11833 O57429 1001 1.2e-106 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF12422//PF15957//PF00443//PF05427 Condensin II non structural maintenance of chromosomes subunit//Commissureless//Ubiquitin carboxyl-terminal hydrolase//Acidic fibroblast growth factor binding (FIBP) GO:0016579//GO:0007411 protein deubiquitination//axon guidance GO:0017134//GO:0016787//GO:0036459 fibroblast growth factor binding//hydrolase activity//ubiquitinyl hydrolase activity GO:0005634 nucleus KOG1868 Ubiquitin C-terminal hydrolase Cluster-8309.40071 BP_3 126.59 1.17 5489 642934565 XP_008197717.1 3683 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 7.8e-93 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0000166//GO:0005524//GO:0016773 protein kinase activity//nucleotide binding//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.40072 BP_3 113.13 0.94 6071 641682104 XP_008189718.1 666 2.3e-66 PREDICTED: uncharacterized protein LOC100570869 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q96DM1 150 6.6e-08 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF02609 Exonuclease VII small subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.40073 BP_3 17.00 2.77 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40074 BP_3 1054.00 19.62 2881 189236096 XP_973523.2 1913 2.8e-211 PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918899|ref|XP_008191647.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918901|ref|XP_008191648.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918903|ref|XP_008191649.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918906|ref|XP_008191650.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|270005619|gb|EFA02067.1| hypothetical protein TcasGA2_TC007700 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5QJ74 711 2.8e-73 Tubulin-specific chaperone cofactor E-like protein OS=Homo sapiens GN=TBCEL PE=1 SV=2 PF01780//PF14560//PF00240//PF00564//PF13855 Ribosomal L37ae protein family//Ubiquitin-like domain//Ubiquitin family//PB1 domain//Leucine rich repeat GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG2982 Uncharacterized conserved protein Cluster-8309.40077 BP_3 4.00 0.49 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40079 BP_3 993.44 7.56 6627 270007202 EFA03650.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013744 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.90077e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 O88477 954 4.2e-101 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Mus musculus GN=Igf2bp1 PE=1 SV=1 PF00013//PF13014//PF13184//PF00076//PF07650//PF04061 KH domain//KH domain//NusA-like KH domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//KH domain//ORMDL family -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.40081 BP_3 63.84 0.35 9105 91082383 XP_968748.1 3389 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.44206e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2467 2.1e-276 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF01926//PF00158//PF13304//PF00437//PF00005//PF03266//PF03193//PF01637//PF02367//PF06414//PF01580//PF00931 ABC transporter transmembrane region//50S ribosome-binding GTPase//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//Type II/IV secretion system protein//ABC transporter//NTPase//Protein of unknown function, DUF258//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//FtsK/SpoIIIE family//NB-ARC domain GO:0006810//GO:0055085//GO:0006355//GO:0002949 transport//transmembrane transport//regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0008134//GO:0098519//GO:0005524//GO:0042626//GO:0016887//GO:0016301//GO:0000166//GO:0043531//GO:0003677//GO:0017111//GO:0005525 GTPase activity//transcription factor binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//nucleotide binding//ADP binding//DNA binding//nucleoside-triphosphatase activity//GTP binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.40082 BP_3 4909.98 128.53 2133 546685573 ERL95060.1 828 1.3e-85 hypothetical protein D910_12330 [Dendroctonus ponderosae] 642926883 XM_967083.3 40 5.58649e-09 PREDICTED: Tribolium castaneum neuroblastoma, suppression of tumorigenicity 1 (LOC660885), mRNA K19558 NBL1 neuroblastoma suppressor of tumorigenicity 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19558 Q6NZ13 229 1.6e-17 Neuroblastoma suppressor of tumorigenicity 1 OS=Danio rerio GN=nbl1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40084 BP_3 152.91 5.60 1609 546675018 ERL86281.1 1576 1.9e-172 hypothetical protein D910_03690 [Dendroctonus ponderosae] -- -- -- -- -- K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 Q58DW2 1175 2.4e-127 Cystathionine gamma-lyase OS=Bos taurus GN=CTH PE=2 SV=1 PF00155//PF01212//PF01053 Aminotransferase class I and II//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.40085 BP_3 61.61 0.75 4248 546676946 ERL87870.1 631 1.9e-62 hypothetical protein D910_05258 [Dendroctonus ponderosae] 817210375 XM_012425850.1 72 1.82383e-26 PREDICTED: Orussus abietinus gamma-aminobutyric acid receptor-associated protein (LOC105700198), mRNA K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 P82890 429 2.0e-40 Low molecular weight phosphotyrosine protein phosphatase 1 OS=Drosophila melanogaster GN=primo-1 PE=2 SV=1 PF00961 LAGLIDADG endonuclease -- -- GO:0004519 endonuclease activity -- -- KOG3217 Protein tyrosine phosphatase Cluster-8309.40086 BP_3 117.00 16.77 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40088 BP_3 1135.00 16.47 3614 642924598 XP_008194358.1 2853 0.0e+00 PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924600|ref|XP_008194359.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924602|ref|XP_008194360.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum] 642924601 XM_008196138.1 354 0 PREDICTED: Tribolium castaneum rho-associated protein kinase 1 (LOC663533), transcript variant X3, mRNA K04514 ROCK1 Rho-associated protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04514 Q13464 1696 2.1e-187 Rho-associated protein kinase 1 OS=Homo sapiens GN=ROCK1 PE=1 SV=1 PF00069//PF04111//PF07714//PF06005//PF08172//PF00433//PF10473//PF06160//PF08718 Protein kinase domain//Autophagy protein Apg6//Protein tyrosine kinase//Protein of unknown function (DUF904)//CASP C terminal//Protein kinase C terminal domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Glycolipid transfer protein (GLTP) GO:0006914//GO:0009069//GO:0006468//GO:0006891//GO:0046836//GO:0016310//GO:0000921//GO:0043093//GO:0000917 autophagy//serine family amino acid metabolic process//protein phosphorylation//intra-Golgi vesicle-mediated transport//glycolipid transport//phosphorylation//septin ring assembly//FtsZ-dependent cytokinesis//barrier septum assembly GO:0005524//GO:0045502//GO:0008134//GO:0004674//GO:0017089//GO:0051861//GO:0042803//GO:0004672 ATP binding//dynein binding//transcription factor binding//protein serine/threonine kinase activity//glycolipid transporter activity//glycolipid binding//protein homodimerization activity//protein kinase activity GO:0016021//GO:0005940//GO:0005737//GO:0030286//GO:0005667//GO:0030173 integral component of membrane//septin ring//cytoplasm//dynein complex//transcription factor complex//integral component of Golgi membrane KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.40089 BP_3 917.08 18.34 2702 270007326 EFA03774.1 1529 8.8e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 P56960 841 2.2e-88 Exosome component 10 OS=Mus musculus GN=Exosc10 PE=1 SV=2 PF08066//PF02456//PF01612 PMC2NT (NUC016) domain//Adenovirus IVa2 protein//3'-5' exonuclease GO:0006396//GO:0006139//GO:0019083 RNA processing//nucleobase-containing compound metabolic process//viral transcription GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.40090 BP_3 342.71 2.93 5927 332374566 AEE62424.1 484 2.9e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 232 2.0e-17 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF01258//PF01853//PF00412 Prokaryotic dksA/traR C4-type zinc finger//MOZ/SAS family//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0016747 zinc ion binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40091 BP_3 1286.80 51.29 1501 642916856 XP_968783.3 998 1.8e-105 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41073 357 1.6e-32 Zinc finger protein on ecdysone puffs OS=Drosophila melanogaster GN=Pep PE=1 SV=1 PF00096//PF04988//PF13912 Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.40092 BP_3 2193.04 14.13 7775 642938169 XP_008190998.1 1053 4.0e-111 PREDICTED: G-protein coupled receptor Mth2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 470 6.6e-45 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF04644//PF00001//PF06652//PF00002 Motilin/ghrelin//7 transmembrane receptor (rhodopsin family)//Methuselah N-terminus//7 transmembrane receptor (Secretin family) GO:0007165//GO:0007186//GO:0006950 signal transduction//G-protein coupled receptor signaling pathway//response to stress GO:0005179//GO:0004930 hormone activity//G-protein coupled receptor activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.40093 BP_3 55.25 0.67 4248 270010219 EFA06667.1 2521 1.3e-281 hypothetical protein TcasGA2_TC009594 [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 931 1.3e-98 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF00651//PF07646//PF01344 BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.40095 BP_3 163.55 1.18 6957 189234221 XP_972511.2 771 1.8e-78 PREDICTED: zinc finger C4H2 domain-containing protein isoform X1 [Tribolium castaneum] 752869764 XM_011253703.1 65 2.33208e-22 PREDICTED: Camponotus floridanus zinc finger C4H2 domain-containing protein (LOC105248746), transcript variant X4, mRNA -- -- -- -- Q9NQZ6 379 2.1e-34 Zinc finger C4H2 domain-containing protein OS=Homo sapiens GN=ZC4H2 PE=1 SV=1 PF03854//PF05715//PF02251//PF00769//PF03229 P-11 zinc finger//Piccolo Zn-finger//Proteasome activator pa28 alpha subunit//Ezrin/radixin/moesin family//Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process GO:0003723//GO:0008092//GO:0046872//GO:0008270 RNA binding//cytoskeletal protein binding//metal ion binding//zinc ion binding GO:0008537//GO:0019898//GO:0005737//GO:0045202 proteasome activator complex//extrinsic component of membrane//cytoplasm//synapse -- -- Cluster-8309.40096 BP_3 4722.20 187.91 1503 642918278 XP_967503.3 720 3.2e-73 PREDICTED: nucleoside diphosphate kinase [Tribolium castaneum] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 P08879 629 4.7e-64 Nucleoside diphosphate kinase OS=Drosophila melanogaster GN=awd PE=1 SV=3 PF00334 Nucleoside diphosphate kinase GO:0006144//GO:0006183//GO:0006228//GO:0006165//GO:0006206//GO:0006241 purine nucleobase metabolic process//GTP biosynthetic process//UTP biosynthetic process//nucleoside diphosphate phosphorylation//pyrimidine nucleobase metabolic process//CTP biosynthetic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.40097 BP_3 113.96 0.80 7177 91083759 XP_971689.1 2098 2.5e-232 PREDICTED: translocation protein SEC63 homolog [Tribolium castaneum] 241591921 XM_002403988.1 183 6.10235e-88 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 1438 3.4e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF01591//PF00973//PF05470//PF06414 6-phosphofructo-2-kinase//Paramyxovirus nucleocapsid protein//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Zeta toxin GO:0006446//GO:0006000//GO:0006013//GO:0006413 regulation of translational initiation//fructose metabolic process//mannose metabolic process//translational initiation GO:0005198//GO:0003873//GO:0003743//GO:0005524//GO:0016301//GO:0031369 structural molecule activity//6-phosphofructo-2-kinase activity//translation initiation factor activity//ATP binding//kinase activity//translation initiation factor binding GO:0019013//GO:0005852//GO:0005840 viral nucleocapsid//eukaryotic translation initiation factor 3 complex//ribosome KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.40098 BP_3 24.17 0.59 2270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40099 BP_3 796.12 5.69 7040 91083759 XP_971689.1 2098 2.4e-232 PREDICTED: translocation protein SEC63 homolog [Tribolium castaneum] 241591921 XM_002403988.1 183 5.98526e-88 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 1435 7.5e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF05470//PF06414//PF00973//PF01591 Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Zeta toxin//Paramyxovirus nucleocapsid protein//6-phosphofructo-2-kinase GO:0006446//GO:0006000//GO:0006013//GO:0006413 regulation of translational initiation//fructose metabolic process//mannose metabolic process//translational initiation GO:0005198//GO:0003873//GO:0003743//GO:0005524//GO:0016301//GO:0031369 structural molecule activity//6-phosphofructo-2-kinase activity//translation initiation factor activity//ATP binding//kinase activity//translation initiation factor binding GO:0019013//GO:0005852//GO:0005840 viral nucleocapsid//eukaryotic translation initiation factor 3 complex//ribosome KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.40100 BP_3 15.76 1.08 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40101 BP_3 671.95 4.65 7252 642935775 XP_008198168.1 1750 5.6e-192 PREDICTED: integrin alpha-PS3-like [Tribolium castaneum] -- -- -- -- -- K17595 SPATA2 spermatogenesis-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17595 O44386 660 5.7e-67 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 PF00641//PF08516 Zn-finger in Ran binding protein and others//ADAM cysteine-rich GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.40102 BP_3 2457.05 16.71 7381 646715813 KDR19281.1 1054 2.9e-111 Schwannomin-interacting protein 1 [Zootermopsis nevadensis] 642924593 XM_008196134.1 241 3.59508e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 681 2.1e-69 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.40103 BP_3 254.19 3.35 3944 642917757 XP_008191356.1 425 1.3e-38 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 54 1.71631e-16 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.40104 BP_3 2333.14 22.23 5351 642917757 XP_008191356.1 961 1.3e-100 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917758 XM_008193135.1 165 4.60875e-78 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF03285//PF00199//PF01695 Paralemmin//Catalase//IstB-like ATP binding protein GO:0006979//GO:0006804//GO:0015947//GO:0008360//GO:0055114//GO:0006568 response to oxidative stress//obsolete peroxidase reaction//methane metabolic process//regulation of cell shape//oxidation-reduction process//tryptophan metabolic process GO:0005524//GO:0004096//GO:0020037 ATP binding//catalase activity//heme binding GO:0016020 membrane -- -- Cluster-8309.40109 BP_3 42.43 0.32 6759 189240851 XP_001812556.1 3106 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein Mi-2 homolog isoform X2 [Tribolium castaneum] 242023689 XM_002432219.1 530 0 Pediculus humanus corporis Chromodomain helicase-DNA-binding protein, putative, mRNA K11643 CHD4, MI2B chromodomain-helicase-DNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11643 O97159 2731 3.8e-307 Chromodomain-helicase-DNA-binding protein Mi-2 homolog OS=Drosophila melanogaster GN=Mi-2 PE=1 SV=2 PF00130//PF08073//PF12678//PF00628//PF00001//PF06357//PF08074//PF05793//PF04851//PF00176 Phorbol esters/diacylglycerol binding domain (C1 domain)//CHDNT (NUC034) domain//RING-H2 zinc finger//PHD-finger//7 transmembrane receptor (rhodopsin family)//Omega-atracotoxin//CHDCT2 (NUC038) domain//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain GO:0035556//GO:0007186//GO:0006355//GO:0006952//GO:0006810//GO:0009405//GO:0006367//GO:0032968 intracellular signal transduction//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//defense response//transport//pathogenesis//transcription initiation from RNA polymerase II promoter//positive regulation of transcription elongation from RNA polymerase II promoter GO:0016818//GO:0019855//GO:0008270//GO:0005524//GO:0016787//GO:0005515//GO:0003677//GO:0004930 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//calcium channel inhibitor activity//zinc ion binding//ATP binding//hydrolase activity//protein binding//DNA binding//G-protein coupled receptor activity GO:0016021//GO:0005576//GO:0005634 integral component of membrane//extracellular region//nucleus KOG0383 Predicted helicase Cluster-8309.40110 BP_3 48.13 0.33 7252 189240851 XP_001812556.1 5483 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein Mi-2 homolog isoform X2 [Tribolium castaneum] 815926192 XM_012392264.1 601 0 PREDICTED: Bombus impatiens chromodomain-helicase-DNA-binding protein Mi-2 homolog (LOC100740721), transcript variant X10, mRNA K11643 CHD4, MI2B chromodomain-helicase-DNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11643 O97159 4696 0.0e+00 Chromodomain-helicase-DNA-binding protein Mi-2 homolog OS=Drosophila melanogaster GN=Mi-2 PE=1 SV=2 PF00176//PF10261//PF04851//PF00641//PF08074//PF00270//PF06357//PF00628//PF00001//PF08073//PF00130//PF05529 SNF2 family N-terminal domain//Inositol phospholipid synthesis and fat-storage-inducing TM//Type III restriction enzyme, res subunit//Zn-finger in Ran binding protein and others//CHDCT2 (NUC038) domain//DEAD/DEAH box helicase//Omega-atracotoxin//PHD-finger//7 transmembrane receptor (rhodopsin family)//CHDNT (NUC034) domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//B-cell receptor-associated protein 31-like GO:0035556//GO:0007186//GO:0006355//GO:0006886//GO:0006810//GO:0006952//GO:0009405//GO:0019915 intracellular signal transduction//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//intracellular protein transport//transport//defense response//pathogenesis//lipid storage GO:0019855//GO:0016818//GO:0008270//GO:0016787//GO:0005524//GO:0003676//GO:0005515//GO:0003677//GO:0004930 calcium channel inhibitor activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//hydrolase activity//ATP binding//nucleic acid binding//protein binding//DNA binding//G-protein coupled receptor activity GO:0016021//GO:0005576//GO:0005783//GO:0005789//GO:0005634 integral component of membrane//extracellular region//endoplasmic reticulum//endoplasmic reticulum membrane//nucleus KOG0383 Predicted helicase Cluster-8309.40111 BP_3 61.13 0.46 6761 189240851 XP_001812556.1 5483 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein Mi-2 homolog isoform X2 [Tribolium castaneum] 815926192 XM_012392264.1 601 0 PREDICTED: Bombus impatiens chromodomain-helicase-DNA-binding protein Mi-2 homolog (LOC100740721), transcript variant X10, mRNA K11643 CHD4, MI2B chromodomain-helicase-DNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11643 O97159 4696 0.0e+00 Chromodomain-helicase-DNA-binding protein Mi-2 homolog OS=Drosophila melanogaster GN=Mi-2 PE=1 SV=2 PF00641//PF04851//PF00176//PF00270//PF08074//PF00001//PF00628//PF06357//PF00130//PF09111//PF08073 Zn-finger in Ran binding protein and others//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//DEAD/DEAH box helicase//CHDCT2 (NUC038) domain//7 transmembrane receptor (rhodopsin family)//PHD-finger//Omega-atracotoxin//Phorbol esters/diacylglycerol binding domain (C1 domain)//SLIDE//CHDNT (NUC034) domain GO:0009405//GO:0006338//GO:0006952//GO:0006810//GO:0007186//GO:0006355//GO:0035556 pathogenesis//chromatin remodeling//defense response//transport//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0004930//GO:0005515//GO:0003676//GO:0005524//GO:0016787//GO:0008270//GO:0016818//GO:0019855 DNA binding//G-protein coupled receptor activity//protein binding//nucleic acid binding//ATP binding//hydrolase activity//zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//calcium channel inhibitor activity GO:0005634//GO:0005576//GO:0016021 nucleus//extracellular region//integral component of membrane KOG0383 Predicted helicase Cluster-8309.40112 BP_3 112.61 0.60 9272 642918205 XP_008191410.1 10225 0.0e+00 PREDICTED: zinc finger homeobox protein 4 isoform X3 [Tribolium castaneum] 642918206 XM_008193189.1 795 0 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X4, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 Q15911 1905 3.1e-211 Zinc finger homeobox protein 3 OS=Homo sapiens GN=ZFHX3 PE=1 SV=2 PF05920//PF13411//PF13912//PF01435//PF00046//PF04988//PF00096 Homeobox KN domain//MerR HTH family regulatory protein//C2H2-type zinc finger//Peptidase family M48//Homeobox domain//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0003677//GO:0004222//GO:0046872 DNA binding//metalloendopeptidase activity//metal ion binding GO:0005634 nucleus KOG1146 Homeobox protein Cluster-8309.40114 BP_3 1407.91 20.21 3649 91088789 XP_968000.1 859 5.9e-89 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35859 291 1.8e-24 Insulin-like growth factor-binding protein complex acid labile subunit OS=Rattus norvegicus GN=Igfals PE=1 SV=1 PF00560//PF13855//PF01943 Leucine Rich Repeat//Leucine rich repeat//Polysaccharide biosynthesis protein GO:0000271 polysaccharide biosynthetic process GO:0005515 protein binding GO:0016020 membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.40115 BP_3 1083.07 4.60 11648 642937892 XP_008200345.1 13462 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 2.1179e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 8471 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF02207//PF03875//PF04410//PF02806//PF03488 Putative zinc finger in N-recognin (UBR box)//Statherin//Gar1/Naf1 RNA binding region//Alpha amylase, C-terminal all-beta domain//Nematode insulin-related peptide beta type GO:0042742//GO:0007165//GO:0030500//GO:0005975//GO:0001522//GO:0042254 defense response to bacterium//signal transduction//regulation of bone mineralization//carbohydrate metabolic process//pseudouridine synthesis//ribosome biogenesis GO:0005179//GO:0046848//GO:0003824//GO:0043169//GO:0008270 hormone activity//hydroxyapatite binding//catalytic activity//cation binding//zinc ion binding GO:0005576 extracellular region KOG1776 Zn-binding protein Push Cluster-8309.40116 BP_3 2165.74 21.99 5038 642924400 XP_008194280.1 612 3.5e-60 PREDICTED: serine/arginine repetitive matrix protein 1 [Tribolium castaneum] -- -- -- -- -- K13171 SRRM1, SRM160 serine/arginine repetitive matrix protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13171 Q8IYB3 439 1.7e-41 Serine/arginine repetitive matrix protein 1 OS=Homo sapiens GN=SRRM1 PE=1 SV=2 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2146 Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) Cluster-8309.40117 BP_3 2252.75 22.97 5019 642924400 XP_008194280.1 564 1.3e-54 PREDICTED: serine/arginine repetitive matrix protein 1 [Tribolium castaneum] -- -- -- -- -- K13171 SRRM1, SRM160 serine/arginine repetitive matrix protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13171 Q8IYB3 415 1.0e-38 Serine/arginine repetitive matrix protein 1 OS=Homo sapiens GN=SRRM1 PE=1 SV=2 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2146 Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) Cluster-8309.40120 BP_3 72.05 0.90 4154 817212894 XP_012282646.1 2856 0.0e+00 PREDICTED: armadillo segment polarity protein isoform X1 [Orussus abietinus] 642934620 XM_008199519.1 550 0 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 2821 0.0e+00 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 PF10508//PF02985//PF01602//PF00514 Proteasome non-ATPase 26S subunit//HEAT repeat//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0043248//GO:0006886//GO:0016192 proteasome assembly//intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117 membrane coat KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.40122 BP_3 1387.95 27.40 2733 642926377 XP_008194900.1 1645 3.2e-180 PREDICTED: serine proteinase stubble [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17538 263 2.3e-21 Chymotrypsinogen B OS=Homo sapiens GN=CTRB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40123 BP_3 162.08 3.45 2556 270010381 EFA06829.1 1047 6.5e-111 hypothetical protein TcasGA2_TC009771 [Tribolium castaneum] -- -- -- -- -- K14782 AATF, BFR2 protein AATF/BFR2 http://www.genome.jp/dbget-bin/www_bget?ko:K14782 Q9JKX4 549 1.5e-54 Protein AATF OS=Mus musculus GN=Aatf PE=1 SV=1 PF08164 Apoptosis-antagonizing transcription factor, C-terminal -- -- -- -- GO:0005634 nucleus KOG2773 Apoptosis antagonizing transcription factor/protein transport protein Cluster-8309.40124 BP_3 591.61 3.73 7930 478254915 ENN75149.1 2582 2.1e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.65135e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.6e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF00665//PF13683//PF01534//PF01392//PF08465 Integrase core domain//Integrase core domain//Frizzled/Smoothened family membrane region//Fz domain//Thymidine kinase from Herpesvirus C-terminal GO:0006230//GO:0015074//GO:0007166//GO:0006206 TMP biosynthetic process//DNA integration//cell surface receptor signaling pathway//pyrimidine nucleobase metabolic process GO:0005515//GO:0005524//GO:0004797 protein binding//ATP binding//thymidine kinase activity GO:0016020 membrane -- -- Cluster-8309.40125 BP_3 3312.16 20.64 8025 478254915 ENN75149.1 2582 2.1e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.67123e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.6e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF08465//PF01534//PF13683//PF01392//PF00665 Thymidine kinase from Herpesvirus C-terminal//Frizzled/Smoothened family membrane region//Integrase core domain//Fz domain//Integrase core domain GO:0006230//GO:0006206//GO:0015074//GO:0007166 TMP biosynthetic process//pyrimidine nucleobase metabolic process//DNA integration//cell surface receptor signaling pathway GO:0004797//GO:0005524//GO:0005515 thymidine kinase activity//ATP binding//protein binding GO:0016020 membrane -- -- Cluster-8309.40126 BP_3 169.05 0.85 9834 270017072 EFA13518.1 1224 7.5e-131 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1016 4.1e-108 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00098//PF00665//PF09207 Zinc knuckle//Integrase core domain//Yeast killer toxin GO:0015074//GO:0008219//GO:0009405 DNA integration//cell death//pathogenesis GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.40127 BP_3 485.18 4.13 5957 642928815 XP_967995.2 1351 8.5e-146 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 167 6.9e-10 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40128 BP_3 2005.57 12.43 8066 91091742 XP_966408.1 1295 3.6e-139 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 953 6.7e-101 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF00202//PF02424//PF03431 Aminotransferase class-III//ApbE family//RNA replicase, beta-chain GO:0008152//GO:0019079//GO:0017013//GO:0006144 metabolic process//viral genome replication//protein flavinylation//purine nucleobase metabolic process GO:0003968//GO:0030170//GO:0008483 RNA-directed RNA polymerase activity//pyridoxal phosphate binding//transaminase activity GO:0031379 RNA-directed RNA polymerase complex KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.40129 BP_3 680.62 11.91 3046 642913258 XP_008201460.1 815 6.2e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 174 2.59164e-83 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 712 2.2e-73 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40132 BP_3 986.16 5.94 8287 642918318 XP_008191457.1 4577 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 482691326 XM_001353419.3 176 5.48948e-84 Drosophila pseudoobscura pseudoobscura GA16861 (Dpse\GA16861), partial mRNA K06768 DSCAML1 Down syndrome cell adhesion molecule-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06768 Q9VS29 3560 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF04120//PF00041//PF13895//PF16656//PF07749 Low affinity iron permease//Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Endoplasmic reticulum protein ERp29, C-terminal domain GO:0019497//GO:0006771//GO:0055085 hexachlorocyclohexane metabolic process//riboflavin metabolic process//transmembrane transport GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.40134 BP_3 86.28 0.83 5312 2072951 AAC51263.1 199 2.9e-12 putative p150 [Homo sapiens] 18042322 AC074239.5 38 1.81675e-07 Homo sapiens BAC clone CTD-2011N5 from 2, complete sequence -- -- -- -- O00370 194 4.5e-13 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40135 BP_3 183.00 50.52 466 646708946 KDR15061.1 415 2.3e-38 Puromycin-sensitive aminopeptidase [Zootermopsis nevadensis] -- -- -- -- -- K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 P55786 285 1.1e-24 Puromycin-sensitive aminopeptidase OS=Homo sapiens GN=NPEPPS PE=1 SV=2 PF05778 Apolipoprotein CIII (Apo-CIII) GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.40136 BP_3 232.82 1.69 6921 642935550 XP_008198055.1 345 4.4e-29 PREDICTED: toxin S6C6 [Tribolium castaneum] -- -- -- -- -- K04008 CD59 CD59 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K04008 -- -- -- -- PF01051//PF00087//PF05924 Initiator Replication protein//Snake toxin//SAMP Motif GO:0009405//GO:0016055//GO:0006270//GO:0006260 pathogenesis//Wnt signaling pathway//DNA replication initiation//DNA replication GO:0003887//GO:0008013 DNA-directed DNA polymerase activity//beta-catenin binding GO:0042575//GO:0005727//GO:0005576//GO:0016342 DNA polymerase complex//extrachromosomal circular DNA//extracellular region//catenin complex -- -- Cluster-8309.40137 BP_3 507.00 8.04 3333 641658119 XP_008180607.1 298 6.0e-24 PREDICTED: zinc finger protein 62 homolog [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q9NQZ8 290 2.1e-24 Endothelial zinc finger protein induced by tumor necrosis factor alpha OS=Homo sapiens GN=ZNF71 PE=2 SV=1 PF13465//PF08493//PF00096//PF13912//PF02892//PF05191//PF16622 Zinc-finger double domain//Aflatoxin regulatory protein//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0046034//GO:0006144//GO:0045122//GO:0006355 ATP metabolic process//purine nucleobase metabolic process//aflatoxin biosynthetic process//regulation of transcription, DNA-templated GO:0003677//GO:0046872//GO:0004017 DNA binding//metal ion binding//adenylate kinase activity GO:0005634 nucleus -- -- Cluster-8309.40140 BP_3 48.95 0.36 6829 270016479 EFA12925.1 288 1.8e-22 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22897 257 2.9e-20 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.40143 BP_3 23.75 0.63 2104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40144 BP_3 35.20 0.90 2185 815825474 XP_012234113.1 291 2.6e-23 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [Linepithema humile] -- -- -- -- -- K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P82471 278 3.4e-23 Guanine nucleotide-binding protein G(q) subunit alpha OS=Rattus norvegicus GN=Gnaq PE=2 SV=2 PF00503 G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0003924//GO:0031683//GO:0019001//GO:0004871 GTPase activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.40145 BP_3 181.54 6.31 1678 167444210 ABZ80666.1 1036 8.1e-110 tollip-like protein [Sitophilus zeamais] -- -- -- -- -- K05402 TOLLIP toll-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05402 A2RUW1 649 2.5e-66 Toll-interacting protein OS=Rattus norvegicus GN=Tollip PE=2 SV=1 PF02845//PF00168 CUE domain//C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40146 BP_3 468.00 8.83 2847 91088771 XP_966660.1 2115 1.0e-234 PREDICTED: mucolipin-3 [Tribolium castaneum]>gi|270012727|gb|EFA09175.1| TRPL [Tribolium castaneum] -- -- -- -- -- K05329 TRPML mucolipin http://www.genome.jp/dbget-bin/www_bget?ko:K05329 Q8R4F0 892 2.8e-94 Mucolipin-3 OS=Mus musculus GN=Mcoln3 PE=1 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3733 Mucolipidin and related proteins (TRML subfamily of transient receptor potential proteins) Cluster-8309.40147 BP_3 5.22 0.44 858 478256566 ENN76750.1 197 8.0e-13 hypothetical protein YQE_06815, partial [Dendroctonus ponderosae]>gi|546680028|gb|ERL90390.1| hypothetical protein D910_07739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05722 Ustilago B locus mating-type protein -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.40148 BP_3 155.69 0.84 9265 642924084 XP_008193999.1 5676 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X1 [Tribolium castaneum] 642924089 XM_008195780.1 744 0 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 12 (LOC656353), transcript variant X4, mRNA K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q86YW9 2448 3.4e-274 Mediator of RNA polymerase II transcription subunit 12-like protein OS=Homo sapiens GN=MED12L PE=1 SV=2 PF09497 Transcription mediator complex subunit Med12 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3598 Thyroid hormone receptor-associated protein complex, subunit TRAP230 Cluster-8309.40149 BP_3 69.00 2.04 1924 478257407 ENN77563.1 205 2.1e-13 hypothetical protein YQE_05859, partial [Dendroctonus ponderosae]>gi|546677746|gb|ERL88525.1| hypothetical protein D910_05911 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40151 BP_3 110.72 1.86 3166 546685504 ERL95002.1 827 2.6e-85 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40154 BP_3 266.87 2.27 5969 270002665 EEZ99112.1 1298 1.2e-139 hypothetical protein TcasGA2_TC005005 [Tribolium castaneum] 817188844 XM_012433587.1 77 4.26859e-29 PREDICTED: Orussus abietinus RING finger protein 44 (LOC105704395), partial mRNA K19041 RNF38_44 E3 ubiquitin-protein ligase RNF38/44 http://www.genome.jp/dbget-bin/www_bget?ko:K19041 Q08CG8 412 2.7e-38 RING finger protein 44 OS=Danio rerio GN=rnf44 PE=2 SV=1 PF00097//PF12906//PF17123//PF12678//PF14634//PF00287//PF12861//PF13639 Zinc finger, C3HC4 type (RING finger)//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Sodium / potassium ATPase beta chain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0006814//GO:0006813//GO:0016567 sodium ion transport//potassium ion transport//protein ubiquitination GO:0008270//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005890//GO:0005680 sodium:potassium-exchanging ATPase complex//anaphase-promoting complex -- -- Cluster-8309.40156 BP_3 33.29 0.54 3287 546676114 ERL87181.1 2053 1.9e-227 hypothetical protein D910_04581 [Dendroctonus ponderosae] 642913385 XM_964220.3 287 4.27239e-146 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q5U2P1 1070 7.4e-115 Metal transporter CNNM2 OS=Rattus norvegicus GN=Cnnm2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.40157 BP_3 383.92 4.26 4638 332374190 AEE62236.1 1087 2.7e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02967 RP-S2, MRPS2, rpsB small subunit ribosomal protein S2 http://www.genome.jp/dbget-bin/www_bget?ko:K02967 Q9Y399 684 6.0e-70 28S ribosomal protein S2, mitochondrial OS=Homo sapiens GN=MRPS2 PE=1 SV=1 PF02558//PF00318//PF00106//PF01370 Ketopantoate reductase PanE/ApbA//Ribosomal protein S2//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0042254//GO:0055114//GO:0006412//GO:0015940//GO:0008152 ribosome biogenesis//oxidation-reduction process//translation//pantothenate biosynthetic process//metabolic process GO:0008677//GO:0003735//GO:0016491//GO:0003824//GO:0050662 2-dehydropantoate 2-reductase activity//structural constituent of ribosome//oxidoreductase activity//catalytic activity//coenzyme binding GO:0005622//GO:0005840 intracellular//ribosome KOG1205 Predicted dehydrogenase Cluster-8309.40159 BP_3 474.63 6.66 3726 91080723 XP_975387.1 919 6.6e-96 PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919596|ref|XP_008191933.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919599|ref|XP_008191934.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|270005868|gb|EFA02316.1| hypothetical protein TcasGA2_TC007982 [Tribolium castaneum] -- -- -- -- -- K16779 RAB3IP, RABIN8 Rab-3A-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K16779 Q99NH3 310 1.1e-26 Guanine nucleotide exchange factor for Rab-3A OS=Rattus norvegicus GN=Rab3il1 PE=1 SV=1 PF02926//PF06008 THUMP domain//Laminin Domain I GO:0045995//GO:0030334//GO:0030155//GO:0007165 regulation of embryonic development//regulation of cell migration//regulation of cell adhesion//signal transduction GO:0003723//GO:0005102 RNA binding//receptor binding -- -- -- -- Cluster-8309.40160 BP_3 149.99 38.96 477 835482914 AKM70276.1 219 1.2e-15 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03823 Neurokinin B GO:0007217 tachykinin receptor signaling pathway -- -- -- -- -- -- Cluster-8309.40161 BP_3 935.48 7.92 5983 642924902 XP_008194090.1 1523 9.7e-166 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.57189e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 1.0e-114 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13202//PF08332//PF00036//PF02022//PF13499//PF10591//PF13833//PF13405 EF hand//Calcium/calmodulin dependent protein kinase II association domain//EF hand//Integrase Zinc binding domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0007165//GO:0016310//GO:0009069//GO:0006468 signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0008270//GO:0005509//GO:0005516//GO:0004683 zinc ion binding//calcium ion binding//calmodulin binding//calmodulin-dependent protein kinase activity GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.40162 BP_3 1210.00 46.68 1541 91083421 XP_969043.1 1251 8.7e-135 PREDICTED: 26S proteasome non-ATPase regulatory subunit 7 [Tribolium castaneum]>gi|270006893|gb|EFA03341.1| hypothetical protein TcasGA2_TC013318 [Tribolium castaneum] 817071326 XM_012402300.1 267 2.59749e-135 PREDICTED: Athalia rosae 26S proteasome non-ATPase regulatory subunit 7 (LOC105686998), mRNA K03038 PSMD7, RPN8 26S proteasome regulatory subunit N8 http://www.genome.jp/dbget-bin/www_bget?ko:K03038 P26270 1170 8.8e-127 26S proteasome non-ATPase regulatory subunit 7 OS=Drosophila melanogaster GN=Rpn8 PE=1 SV=6 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- KOG1556 26S proteasome regulatory complex, subunit RPN8/PSMD7 Cluster-8309.40164 BP_3 239.73 2.71 4549 478250812 ENN71304.1 2515 6.9e-281 hypothetical protein YQE_12229, partial [Dendroctonus ponderosae] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 1430 1.8e-156 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 PF02130//PF00050//PF00093//PF05375//PF07648 Uncharacterized protein family UPF0054//Kazal-type serine protease inhibitor domain//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII)//Kazal-type serine protease inhibitor domain GO:0006364 rRNA processing GO:0005515//GO:0030414//GO:0004222 protein binding//peptidase inhibitor activity//metalloendopeptidase activity -- -- -- -- Cluster-8309.40165 BP_3 1.00 7.27 252 91087441 XP_975685.1 163 2.1e-09 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.40167 BP_3 495.19 13.96 2001 642931094 XP_008196209.1 729 3.8e-74 PREDICTED: serine protease persephone-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWU1 501 4.3e-49 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40168 BP_3 21.53 0.38 3058 167234236 NP_001107808.1 1761 1.3e-193 GABA receptor isoform a precursor [Tribolium castaneum]>gi|156447603|gb|ABU63594.1| GABA-gated anion channel splice variant 3a6a [Tribolium castaneum] 411147304 AB697765.1 549 0 Oulema oryzae OoRdl mRNA for GABA-gated chloride channel, complete cds K05195 GLRA3 glycine receptor alpha-3 http://www.genome.jp/dbget-bin/www_bget?ko:K05195 Q75NA5 1521 3.5e-167 Gamma-aminobutyric acid receptor subunit beta OS=Musca domestica GN=Rdl PE=1 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006821//GO:0007214//GO:0006811 transport//chloride transport//gamma-aminobutyric acid signaling pathway//ion transport GO:0004890//GO:0005230 GABA-A receptor activity//extracellular ligand-gated ion channel activity GO:0005886//GO:0016021//GO:0016020//GO:0030054//GO:0045211 plasma membrane//integral component of membrane//membrane//cell junction//postsynaptic membrane -- -- Cluster-8309.40170 BP_3 44.32 1.55 1669 -- -- -- -- -- 642914349 XM_008203421.1 47 5.58865e-13 PREDICTED: Tribolium castaneum inhibitor of apoptosis 1 (LOC663941), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40171 BP_3 6016.29 98.12 3247 546685733 ERL95188.1 972 4.1e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 2.7e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF14634//PF13639 zinc-RING finger domain//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.40172 BP_3 4910.37 1355.61 466 270005418 EFA01866.1 440 2.9e-41 hypothetical protein TcasGA2_TC007471 [Tribolium castaneum] 642919750 XM_008193828.1 48 4.1202e-14 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 Q5R4D4 294 1.0e-25 Nucleosome assembly protein 1-like 1 OS=Pongo abelii GN=NAP1L1 PE=2 SV=1 PF00956 Nucleosome assembly protein (NAP) GO:0006334 nucleosome assembly -- -- GO:0005634 nucleus KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.40173 BP_3 668.41 15.39 2385 478252477 ENN72899.1 961 5.7e-101 hypothetical protein YQE_10469, partial [Dendroctonus ponderosae]>gi|546682597|gb|ERL92516.1| hypothetical protein D910_09829 [Dendroctonus ponderosae] 642923699 XM_008195626.1 122 1.6325e-54 PREDICTED: Tribolium castaneum uncharacterized LOC103313143 (LOC103313143), mRNA -- -- -- -- Q66IT9 149 3.4e-08 Immediate early response gene 5-like protein OS=Xenopus laevis GN=ier5l PE=2 SV=2 PF07557//PF09726 Shugoshin C terminus//Transmembrane protein GO:0045132 meiotic chromosome segregation -- -- GO:0005634//GO:0000775//GO:0016021 nucleus//chromosome, centromeric region//integral component of membrane -- -- Cluster-8309.40174 BP_3 80.01 4.35 1178 642939241 XP_008194774.1 1159 3.1e-124 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q4JM44 411 6.9e-39 Phosphatidylcholine:ceramide cholinephosphotransferase 2 OS=Rattus norvegicus GN=Sgms2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.40176 BP_3 47.72 1.12 2351 282165792 NP_001164135.1 593 2.6e-58 drongo protein isoform 2 [Tribolium castaneum]>gi|270008252|gb|EFA04700.1| drongo [Tribolium castaneum] -- -- -- -- -- K15044 AGFG1 Arf-GAP domain and FG repeats-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15044 O95081 224 6.7e-17 Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens GN=AGFG2 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0702 Predicted GTPase-activating protein Cluster-8309.40177 BP_3 22.98 0.37 3315 270011248 EFA07696.1 495 8.6e-47 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40179 BP_3 661.55 12.32 2879 642913258 XP_008201460.1 819 2.0e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 175 6.80593e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.3e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40181 BP_3 35.08 0.42 4354 642912272 XP_008200632.1 422 3.3e-38 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P6T1 164 1.1e-09 Complement C1s subcomponent OS=Rattus norvegicus GN=C1s PE=2 SV=2 PF01414//PF00089//PF15965//PF04625 Delta serrate ligand//Trypsin//TRAF-like zinc-finger//DEC-1 protein, N-terminal region GO:0007154//GO:0007304//GO:0006508 cell communication//chorion-containing eggshell formation//proteolysis GO:0005213//GO:0004252//GO:0008270 structural constituent of chorion//serine-type endopeptidase activity//zinc ion binding GO:0042600//GO:0016020//GO:0005576 chorion//membrane//extracellular region -- -- Cluster-8309.40182 BP_3 2867.00 25.51 5708 815925257 XP_012247265.1 1507 6.6e-164 PREDICTED: mucin-17 isoform X1 [Bombus impatiens]>gi|815925259|ref|XP_012247266.1| PREDICTED: mucin-17 isoform X1 [Bombus impatiens] 687869355 LK939485.1 58 1.48864e-18 Angiostrongylus costaricensis genome assembly A_costaricensis_Costa_Rica ,scaffold ACOC_scaffold0000311 K08867 WNK, PRKWNK WNK lysine deficient protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08867 Q9BYP7 1238 4.3e-134 Serine/threonine-protein kinase WNK3 OS=Homo sapiens GN=WNK3 PE=1 SV=3 PF05454//PF05434//PF00069//PF07714//PF12202 Dystroglycan (Dystrophin-associated glycoprotein 1)//TMEM9//Protein kinase domain//Protein tyrosine kinase//Oxidative-stress-responsive kinase 1 C terminal GO:0006468//GO:0009069//GO:0016310//GO:0007016 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//cytoskeletal anchoring at plasma membrane GO:0004674//GO:0004672//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016010//GO:0016021 dystrophin-associated glycoprotein complex//integral component of membrane KOG0584 Serine/threonine protein kinase Cluster-8309.40183 BP_3 34.26 1.07 1835 546674232 ERL85660.1 317 2.1e-26 hypothetical protein D910_03077 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40185 BP_3 270.37 1.30 10301 91090496 XP_969212.1 1701 3.8e-186 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] 642935356 XM_964189.2 200 3.11077e-97 PREDICTED: Tribolium castaneum forkhead box protein P4 (LOC657747), mRNA K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 1044 2.4e-111 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF01546//PF00250//PF01299 Peptidase family M20/M25/M40//Forkhead domain//Lysosome-associated membrane glycoprotein (Lamp) GO:0006508//GO:0006355//GO:0006520//GO:0008152//GO:0000051 proteolysis//regulation of transcription, DNA-templated//cellular amino acid metabolic process//metabolic process//obsolete urea cycle intermediate metabolic process GO:0008237//GO:0043565//GO:0003700//GO:0016787//GO:0004046 metallopeptidase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//hydrolase activity//aminoacylase activity GO:0016020//GO:0005737//GO:0005667 membrane//cytoplasm//transcription factor complex KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.40189 BP_3 71.05 1.64 2375 642910653 XP_968714.2 302 1.5e-24 PREDICTED: polyadenylate-binding protein-interacting protein 2B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4019 BP_3 37.00 0.74 2700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40191 BP_3 1506.85 6.91 10807 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.60708e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF09162//PF04043//PF07714//PF00069//PF01059 Tap, RNA-binding//Plant invertase/pectin methylesterase inhibitor//Protein tyrosine kinase//Protein kinase domain//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006406//GO:0006468//GO:0006120//GO:0055114 mRNA export from nucleus//protein phosphorylation//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process GO:0004857//GO:0005524//GO:0003723//GO:0004672 enzyme inhibitor activity//ATP binding//RNA binding//protein kinase activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG3625 Alpha amylase Cluster-8309.40192 BP_3 35.19 0.47 3898 642928027 XP_008200126.1 2655 3.5e-297 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.64955e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 1139 8.8e-123 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF00038//PF02601//PF03836//PF01920//PF10174//PF00435//PF13202//PF00769//PF00036//PF12763//PF01576//PF10186//PF04111//PF13405//PF13833//PF13499 Intermediate filament protein//Exonuclease VII, large subunit//RasGAP C-terminus//Prefoldin subunit//RIM-binding protein of the cytomatrix active zone//Spectrin repeat//EF hand//Ezrin/radixin/moesin family//EF hand//Cytoskeletal-regulatory complex EF hand//Myosin tail//Vacuolar sorting 38 and autophagy-related subunit 14//Autophagy protein Apg6//EF-hand domain//EF-hand domain pair//EF-hand domain pair GO:0006457//GO:0007264//GO:0006308//GO:0006914//GO:0010508 protein folding//small GTPase mediated signal transduction//DNA catabolic process//autophagy//positive regulation of autophagy GO:0008092//GO:0005515//GO:0008855//GO:0003774//GO:0005509//GO:0005096//GO:0005198//GO:0051082 cytoskeletal protein binding//protein binding//exodeoxyribonuclease VII activity//motor activity//calcium ion binding//GTPase activator activity//structural molecule activity//unfolded protein binding GO:0016459//GO:0019898//GO:0005882//GO:0009318//GO:0048786//GO:0005737//GO:0016272 myosin complex//extrinsic component of membrane//intermediate filament//exodeoxyribonuclease VII complex//presynaptic active zone//cytoplasm//prefoldin complex KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.40193 BP_3 267.44 22.60 862 91080601 XP_974038.1 861 8.1e-90 PREDICTED: mediator of RNA polymerase II transcription subunit 7 [Tribolium castaneum]>gi|270005511|gb|EFA01959.1| hypothetical protein TcasGA2_TC007575 [Tribolium castaneum] -- -- -- -- -- K15148 MED7 mediator of RNA polymerase II transcription subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15148 Q7PR68 598 1.0e-60 Mediator of RNA polymerase II transcription subunit 7 OS=Anopheles gambiae GN=MED7 PE=3 SV=2 PF00042//PF05983 Globin//MED7 protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0020037//GO:0019825//GO:0001104 heme binding//oxygen binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG0570 Transcriptional coactivator Cluster-8309.40195 BP_3 2435.34 24.98 4990 646622486 KDQ71473.1 2274 6.7e-253 Propionyl-CoA carboxylase beta chain, mitochondrial [Zootermopsis nevadensis] 645005303 XR_513193.1 192 4.20551e-93 PREDICTED: Nasonia vitripennis probable serine/threonine-protein kinase dyrk2 (LOC100121588), transcript variant X2, misc_RNA K01966 PCCB, pccB propionyl-CoA carboxylase beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K01966 P79384 2028 9.2e-226 Propionyl-CoA carboxylase beta chain, mitochondrial OS=Sus scrofa GN=PCCB PE=2 SV=1 PF12632//PF00608//PF06833//PF07714//PF00069 Mysoin-binding motif of peroxisomes//Adenoviral fibre protein (repeat/shaft region)//Malonate decarboxylase gamma subunit (MdcE)//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0009405//GO:0019062//GO:0007155 protein phosphorylation//pathogenesis//virion attachment to host cell//cell adhesion GO:0016874//GO:0005524//GO:0004672//GO:0017022 ligase activity//ATP binding//protein kinase activity//myosin binding GO:0016459 myosin complex KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.40196 BP_3 36.32 0.42 4424 91092696 XP_971938.1 3052 0.0e+00 PREDICTED: trafficking protein particle complex subunit 8 [Tribolium castaneum]>gi|270014865|gb|EFA11313.1| hypothetical protein TcasGA2_TC010852 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2L5 1219 5.3e-132 Trafficking protein particle complex subunit 8 OS=Homo sapiens GN=TRAPPC8 PE=1 SV=2 PF13414//PF02883//PF13181//PF00515//PF00377 TPR repeat//Adaptin C-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Prion/Doppel alpha-helical domain GO:0051260//GO:0006886//GO:0016192 protein homooligomerization//intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0016020//GO:0030131 membrane//clathrin adaptor complex KOG1938 Protein with predicted involvement in meiosis (GSG1) Cluster-8309.40203 BP_3 152.88 8.47 1162 642919254 XP_008191795.1 1574 2.3e-172 PREDICTED: uncharacterized protein C05D11.7 isoform X1 [Tribolium castaneum] 569534448 KF724681.1 127 1.30084e-57 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q8BJ56 695 8.0e-72 Patatin-like phospholipase domain-containing protein 2 OS=Mus musculus GN=Pnpla2 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.40204 BP_3 316.00 16.81 1198 642911124 XP_008200590.1 697 1.2e-70 PREDICTED: peflin [Tribolium castaneum]>gi|270014674|gb|EFA11122.1| hypothetical protein TcasGA2_TC004722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UBV8 373 1.8e-34 Peflin OS=Homo sapiens GN=PEF1 PE=1 SV=1 PF13202//PF13833//PF13405//PF00036//PF13499 EF hand//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0037 Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.40205 BP_3 31.63 1.18 1580 91093244 XP_969150.1 1801 1.5e-198 PREDICTED: methionine aminopeptidase 2 [Tribolium castaneum]>gi|270016683|gb|EFA13129.1| hypothetical protein TcasGA2_TC006844 [Tribolium castaneum] 765160084 XM_004083214.2 204 2.80004e-100 PREDICTED: Oryzias latipes methionyl aminopeptidase 2 (metap2), mRNA K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 P38062 1488 1.2e-163 Methionine aminopeptidase 2 OS=Rattus norvegicus GN=Metap2 PE=1 SV=2 PF03839//PF02724 Translocation protein Sec62//CDC45-like protein GO:0009987//GO:0015031//GO:0006508//GO:0006270 cellular process//protein transport//proteolysis//DNA replication initiation GO:0046872//GO:0008235//GO:0004177//GO:0008565 metal ion binding//metalloexopeptidase activity//aminopeptidase activity//protein transporter activity GO:0016021 integral component of membrane KOG2775 Metallopeptidase Cluster-8309.40206 BP_3 15.32 0.41 2075 646705165 KDR13032.1 774 2.4e-79 Ras-like protein 3 [Zootermopsis nevadensis] 642938605 XM_008201640.1 231 3.6195e-115 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 751 4.6e-78 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF08477//PF03193//PF01926//PF00503//PF00071//PF00025//PF00910 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//G-protein alpha subunit//Ras family//ADP-ribosylation factor family//RNA helicase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0004871//GO:0019001//GO:0005525//GO:0003724//GO:0031683//GO:0003723//GO:0003924 signal transducer activity//guanyl nucleotide binding//GTP binding//RNA helicase activity//G-protein beta/gamma-subunit complex binding//RNA binding//GTPase activity -- -- KOG0395 Ras-related GTPase Cluster-8309.40207 BP_3 103.60 1.42 3816 512892422 XP_004922927.1 1127 5.1e-120 PREDICTED: uncharacterized protein LOC101739908 [Bombyx mori] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 468 5.5e-45 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.40208 BP_3 152.34 7.25 1304 642912068 XP_008200785.1 780 3.0e-80 PREDICTED: peroxidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q01603 455 6.0e-44 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.40210 BP_3 25.90 1.15 1380 546685590 ERL95077.1 425 4.7e-39 hypothetical protein D910_12347 [Dendroctonus ponderosae] 658887074 XM_008428179.1 114 2.61627e-50 PREDICTED: Poecilia reticulata clathrin, heavy chain (Hc) (cltc), transcript variant X4, mRNA K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 373 2.1e-34 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF00637 Region in Clathrin and VPS GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport -- -- -- -- KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.40213 BP_3 820.10 11.69 3673 332374310 AEE62296.1 1023 5.7e-108 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 474 1.1e-45 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF01353 Green fluorescent protein GO:0008218 bioluminescence -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.40214 BP_3 625.82 4.67 6745 572308871 XP_006620242.1 1074 1.3e-113 PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X1 [Apis dorsata]>gi|572308873|ref|XP_006620243.1| PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X2 [Apis dorsata] 837814424 XM_012928152.1 259 3.23761e-130 PREDICTED: Ochotona princeps ribose-phosphate pyrophosphokinase 1 (LOC101518950), mRNA K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 Q2HJ58 1002 1.2e-106 Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus GN=PRPS1 PE=2 SV=3 PF14572//PF00160//PF00156 Phosphoribosyl synthetase-associated domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Phosphoribosyl transferase domain GO:0009165//GO:0006144//GO:0006457//GO:0006098//GO:0000413//GO:0009116 nucleotide biosynthetic process//purine nucleobase metabolic process//protein folding//pentose-phosphate shunt//protein peptidyl-prolyl isomerization//nucleoside metabolic process GO:0000287//GO:0004749//GO:0003755 magnesium ion binding//ribose phosphate diphosphokinase activity//peptidyl-prolyl cis-trans isomerase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.40216 BP_3 438.59 7.86 2980 820805524 AKG92753.1 1314 8.3e-142 mnt1 [Leptinotarsa decemlineata] -- -- -- -- -- K09115 MNT, ROX MAX-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09115 O08789 363 6.4e-33 Max-binding protein MNT OS=Mus musculus GN=Mnt PE=2 SV=2 PF04111//PF00010 Autophagy protein Apg6//Helix-loop-helix DNA-binding domain GO:0006914 autophagy GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.4022 BP_3 17.00 0.78 1345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40221 BP_3 4711.10 30.56 7722 642913878 XP_975183.2 7115 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X1 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.50454e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q96C24 760 1.5e-78 Synaptotagmin-like protein 4 OS=Homo sapiens GN=SYTL4 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.40222 BP_3 257.58 1.63 7886 642929402 XP_008195823.1 7387 0.0e+00 PREDICTED: unconventional myosin-Va isoform X2 [Tribolium castaneum] 766917087 XM_011503499.1 99 3.32626e-41 PREDICTED: Ceratosolen solmsi marchali unconventional myosin-Va (LOC105365325), mRNA K10357 MYO5 myosin V http://www.genome.jp/dbget-bin/www_bget?ko:K10357 Q9QYF3 4209 0.0e+00 Unconventional myosin-Va OS=Rattus norvegicus GN=Myo5a PE=1 SV=1 PF01890//PF07716//PF00612//PF00063//PF00584//PF11857//PF08437//PF05902//PF00437 Cobalamin synthesis G C-terminus//Basic region leucine zipper//IQ calmodulin-binding motif//Myosin head (motor domain)//SecE/Sec61-gamma subunits of protein translocation complex//Domain of unknown function (DUF3377)//Glycosyl transferase family 8 C-terminal//4.1 protein C-terminal domain (CTD)//Type II/IV secretion system protein GO:0006605//GO:0006886//GO:0006810//GO:0006355//GO:0009236//GO:0009103 protein targeting//intracellular protein transport//transport//regulation of transcription, DNA-templated//cobalamin biosynthetic process//lipopolysaccharide biosynthetic process GO:0004222//GO:0005524//GO:0003779//GO:0005198//GO:0043565//GO:0003700//GO:0005515//GO:0003774//GO:0008918 metalloendopeptidase activity//ATP binding//actin binding//structural molecule activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding//motor activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0016459//GO:0005856//GO:0005667//GO:0016020 myosin complex//cytoskeleton//transcription factor complex//membrane KOG0160 Myosin class V heavy chain Cluster-8309.40223 BP_3 4942.62 87.64 3010 642921186 XP_008192751.1 888 2.1e-92 PREDICTED: reticulon-1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 482 1.0e-46 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF00834//PF01442 Ribulose-phosphate 3 epimerase family//Apolipoprotein A1/A4/E domain GO:0042157//GO:0005975//GO:0006869 lipoprotein metabolic process//carbohydrate metabolic process//lipid transport GO:0016857//GO:0008289 racemase and epimerase activity, acting on carbohydrates and derivatives//lipid binding GO:0005576 extracellular region KOG1792 Reticulon Cluster-8309.40224 BP_3 3.77 0.32 858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40226 BP_3 517.95 2.24 11412 642910658 XP_008200046.1 10447 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.40227 BP_3 249.03 2.58 4950 270013506 EFA09954.1 2607 1.6e-291 hypothetical protein TcasGA2_TC012107 [Tribolium castaneum] 768421079 XM_011553033.1 246 3.99819e-123 PREDICTED: Plutella xylostella serine/threonine-protein kinase STE20-like (LOC105383024), transcript variant X3, mRNA K06068 PRKCD novel protein kinase C delta type http://www.genome.jp/dbget-bin/www_bget?ko:K06068 P83099 2129 1.8e-237 Putative protein kinase C delta type homolog OS=Drosophila melanogaster GN=Pkcdelta PE=2 SV=3 PF00858//PF04147//PF00069//PF07714//PF00433//PF00628//PF00130 Amiloride-sensitive sodium channel//Nop14-like family//Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006814//GO:0035556//GO:0016310//GO:0006468//GO:0009069 sodium ion transport//intracellular signal transduction//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005272//GO:0005524//GO:0005515 protein kinase activity//protein serine/threonine kinase activity//sodium channel activity//ATP binding//protein binding GO:0016020//GO:0032040 membrane//small-subunit processome KOG0694 Serine/threonine protein kinase Cluster-8309.40228 BP_3 64.55 0.45 7236 642934549 XP_008197710.1 1880 4.7e-207 PREDICTED: axoneme-associated protein mst101(2)-like isoform X2 [Tribolium castaneum] 768421079 XM_011553033.1 246 5.8555e-123 PREDICTED: Plutella xylostella serine/threonine-protein kinase STE20-like (LOC105383024), transcript variant X3, mRNA K06068 PRKCD novel protein kinase C delta type http://www.genome.jp/dbget-bin/www_bget?ko:K06068 P83099 1473 3.0e-161 Putative protein kinase C delta type homolog OS=Drosophila melanogaster GN=Pkcdelta PE=2 SV=3 PF00858//PF00069//PF07714//PF00433 Amiloride-sensitive sodium channel//Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain GO:0006814//GO:0016310//GO:0006468//GO:0009069 sodium ion transport//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005272//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//sodium channel activity//ATP binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.40229 BP_3 84.33 1.36 3279 646696804 KDR08844.1 4269 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component [Zootermopsis nevadensis] 642930974 XM_008197940.1 1005 0 PREDICTED: Tribolium castaneum 116 kDa U5 small nuclear ribonucleoprotein component (LOC661338), mRNA K12852 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component http://www.genome.jp/dbget-bin/www_bget?ko:K12852 Q5F3X4 3877 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component OS=Gallus gallus GN=EFTUD2 PE=2 SV=1 PF03764//PF00071//PF08477//PF03144//PF01926 Elongation factor G, domain IV//Ras family//Ras of Complex, Roc, domain of DAPkinase//Elongation factor Tu domain 2//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0468 U5 snRNP-specific protein Cluster-8309.40230 BP_3 896.39 35.49 1509 642929019 XP_008195657.1 681 1.1e-68 PREDICTED: uncharacterized protein LOC662417 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P01042 137 5.2e-07 Kininogen-1 OS=Homo sapiens GN=KNG1 PE=1 SV=2 PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.40231 BP_3 1076.98 13.43 4157 642924110 XP_008194009.1 2499 4.5e-279 PREDICTED: serine/threonine-protein kinase mig-15 isoform X5 [Tribolium castaneum] 642924109 XM_008195787.1 606 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1483 1.2e-162 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.40232 BP_3 2.00 0.45 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40233 BP_3 38.92 1.68 1411 288899098 ADC67081.1 1332 3.2e-144 proline dehydrogenase isoform 1 [Leptinotarsa decemlineata] 768445391 XM_011566289.1 93 1.26303e-38 PREDICTED: Plutella xylostella proline dehydrogenase 1, mitochondrial (LOC105394397), mRNA K00318 PRODH proline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00318 Q04499 943 1.7e-100 Proline dehydrogenase 1, mitochondrial OS=Drosophila melanogaster GN=slgA PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0186 Proline oxidase Cluster-8309.40235 BP_3 632.08 8.79 3759 642933896 XP_971172.2 2710 1.4e-303 PREDICTED: dual specificity testis-specific protein kinase 2 [Tribolium castaneum] 642933895 XM_966079.3 363 0 PREDICTED: Tribolium castaneum dual specificity testis-specific protein kinase 2 (LOC659807), mRNA K08842 TESK2 testis-specific kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08842 Q96S53 914 1.0e-96 Dual specificity testis-specific protein kinase 2 OS=Homo sapiens GN=TESK2 PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.40236 BP_3 2219.96 21.90 5177 668462939 KFB50382.1 1452 1.4e-157 AGAP005306-PA-like protein [Anopheles sinensis] 751770441 XM_011201182.1 332 6.52138e-171 PREDICTED: Bactrocera dorsalis calcium/calmodulin-dependent protein kinase type 1 (LOC105223446), mRNA K08794 CAMK1 calcium/calmodulin-dependent protein kinase I http://www.genome.jp/dbget-bin/www_bget?ko:K08794 Q9TXJ0 1242 1.3e-134 Calcium/calmodulin-dependent protein kinase type 1 OS=Caenorhabditis elegans GN=cmk-1 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.40237 BP_3 58.23 0.68 4430 91094045 XP_968644.1 1387 4.2e-150 PREDICTED: RNA-binding protein 12 [Tribolium castaneum]>gi|270003124|gb|EEZ99571.1| hypothetical protein TcasGA2_TC001555 [Tribolium castaneum] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 Q9VHR6 650 5.0e-66 Autophagy-related protein 13 homolog OS=Drosophila melanogaster GN=Atg13 PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG3874 Uncharacterized conserved protein Cluster-8309.40239 BP_3 457.77 8.87 2778 817053730 XP_012263556.1 971 4.6e-102 PREDICTED: tafazzin homolog [Athalia rosae] -- -- -- -- -- K13511 TAZ monolysocardiolipin acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13511 Q9V6G5 816 1.8e-85 Tafazzin homolog OS=Drosophila melanogaster GN=Taz PE=2 SV=2 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG2847 Phosphate acyltransferase Cluster-8309.40241 BP_3 2256.62 179.41 898 546681509 ERL91586.1 436 1.6e-40 hypothetical protein D910_08916 [Dendroctonus ponderosae] -- -- -- -- -- K12160 SUMO, SMT3 small ubiquitin-related modifier http://www.genome.jp/dbget-bin/www_bget?ko:K12160 Q6NV25 328 2.2e-29 Small ubiquitin-related modifier 3-like OS=Danio rerio GN=sumo3l PE=3 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG1769 Ubiquitin-like proteins Cluster-8309.40242 BP_3 302.00 9.35 1848 332374554 AEE62418.1 1390 7.9e-151 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 853 6.1e-90 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.40245 BP_3 65.06 0.62 5345 102939 1952 1.6e-215 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1414 1.6e-154 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.40246 BP_3 755.90 11.71 3404 642930288 XP_008196330.1 3568 0.0e+00 PREDICTED: semaphorin-1A isoform X1 [Tribolium castaneum] 642930289 XM_008198109.1 795 0 PREDICTED: Tribolium castaneum semaphorin-1A (LOC660780), transcript variant X2, mRNA K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q24322 2578 1.1e-289 Semaphorin-1A OS=Drosophila melanogaster GN=Sema-1a PE=2 SV=2 PF05700//PF01437//PF01403 Breast carcinoma amplified sequence 2 (BCAS2)//Plexin repeat//Sema domain GO:0006397 mRNA processing GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.40249 BP_3 811.10 12.72 3366 91086569 XP_973078.1 1429 4.3e-155 PREDICTED: E3 ubiquitin-protein ligase AMFR-like [Tribolium castaneum] -- -- -- -- -- K10636 AMFR, GP78 autocrine motility factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10636 Q9UKV5 826 1.5e-86 E3 ubiquitin-protein ligase AMFR OS=Homo sapiens GN=AMFR PE=1 SV=2 PF17122//PF00097//PF17123//PF12906//PF12678//PF14634//PF13639//PF02845//PF12861 Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-variant domain//RING-H2 zinc finger//zinc-RING finger domain//Ring finger domain//CUE domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.40251 BP_3 181.15 2.39 3947 546676985 ERL87909.1 599 8.9e-59 hypothetical protein D910_05297 [Dendroctonus ponderosae] -- -- -- -- -- K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 O61374 367 2.9e-33 Sex-lethal homolog OS=Ceratitis capitata GN=SXL PE=2 SV=2 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.40252 BP_3 28.29 10.40 422 478252124 ENN72555.1 292 3.8e-24 hypothetical protein YQE_10895, partial [Dendroctonus ponderosae] -- -- -- -- -- K18747 SXL protein sex-lethal http://www.genome.jp/dbget-bin/www_bget?ko:K18747 Q15717 170 2.2e-11 ELAV-like protein 1 OS=Homo sapiens GN=ELAVL1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.40253 BP_3 1482.00 10.66 6994 189239891 XP_969420.2 5035 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Tribolium castaneum] 752863719 XM_011269923.1 157 1.68866e-73 PREDICTED: Camponotus floridanus E3 ubiquitin-protein ligase UBR3 (LOC105258579), mRNA K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 1245 8.1e-135 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF02323//PF13639//PF00643//PF02207 Egg-laying hormone precursor//Ring finger domain//B-box zinc finger//Putative zinc finger in N-recognin (UBR box) GO:0007165//GO:0007275 signal transduction//multicellular organismal development GO:0008270//GO:0005179//GO:0005515 zinc ion binding//hormone activity//protein binding GO:0005576//GO:0005622 extracellular region//intracellular KOG1139 Predicted ubiquitin-protein ligase of the N-recognin family Cluster-8309.40254 BP_3 675.22 4.76 7126 189239891 XP_969420.2 6439 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Tribolium castaneum] 752863719 XM_011269923.1 159 1.33018e-74 PREDICTED: Camponotus floridanus E3 ubiquitin-protein ligase UBR3 (LOC105258579), mRNA K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 1589 1.1e-174 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF02323//PF13639//PF02207 Egg-laying hormone precursor//Ring finger domain//Putative zinc finger in N-recognin (UBR box) GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0008270//GO:0005515//GO:0005179 zinc ion binding//protein binding//hormone activity GO:0005576 extracellular region KOG1139 Predicted ubiquitin-protein ligase of the N-recognin family Cluster-8309.40255 BP_3 83.78 0.49 8453 123407101 XP_001302933.1 225 4.5e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.7e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40258 BP_3 256.24 14.80 1126 91087153 XP_975332.1 608 2.3e-60 PREDICTED: 28S ribosomal protein S11, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02948 RP-S11, MRPS11, rpsK small subunit ribosomal protein S11 http://www.genome.jp/dbget-bin/www_bget?ko:K02948 P82911 252 1.8e-20 28S ribosomal protein S11, mitochondrial OS=Bos taurus GN=MRPS11 PE=1 SV=2 PF00411 Ribosomal protein S11 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0408 Mitochondrial/chloroplast ribosomal protein S11 Cluster-8309.40261 BP_3 347.95 5.85 3161 260800283 XP_002595063.1 737 7.1e-75 hypothetical protein BRAFLDRAFT_115226 [Branchiostoma floridae]>gi|229280305|gb|EEN51074.1| hypothetical protein BRAFLDRAFT_115226 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P17038 695 2.2e-71 Zinc finger protein 43 OS=Homo sapiens GN=ZNF43 PE=2 SV=4 PF00096//PF13465//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40263 BP_3 104.12 2.45 2338 91077292 XP_974520.1 2379 2.1e-265 PREDICTED: splicing factor 3A subunit 3 [Tribolium castaneum]>gi|270002083|gb|EEZ98530.1| hypothetical protein TcasGA2_TC001034 [Tribolium castaneum] 242011600 XM_002426492.1 125 3.43865e-56 Pediculus humanus corporis Splicing factor 3A subunit, putative, mRNA K12827 SF3A3, SAP61, PRP9 splicing factor 3A subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12827 Q12874 1856 3.8e-206 Splicing factor 3A subunit 3 OS=Homo sapiens GN=SF3A3 PE=1 SV=1 PF06936 Selenoprotein S (SelS) GO:0006886 intracellular protein transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0030176//GO:0005634 integral component of endoplasmic reticulum membrane//nucleus KOG2636 Splicing factor 3a, subunit 3 Cluster-8309.40264 BP_3 920.92 21.18 2387 91077292 XP_974520.1 2379 2.1e-265 PREDICTED: splicing factor 3A subunit 3 [Tribolium castaneum]>gi|270002083|gb|EEZ98530.1| hypothetical protein TcasGA2_TC001034 [Tribolium castaneum] 242011600 XM_002426492.1 125 3.51181e-56 Pediculus humanus corporis Splicing factor 3A subunit, putative, mRNA K12827 SF3A3, SAP61, PRP9 splicing factor 3A subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12827 Q12874 1856 3.9e-206 Splicing factor 3A subunit 3 OS=Homo sapiens GN=SF3A3 PE=1 SV=1 PF06936 Selenoprotein S (SelS) GO:0006886 intracellular protein transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0030176//GO:0005634 integral component of endoplasmic reticulum membrane//nucleus KOG2636 Splicing factor 3a, subunit 3 Cluster-8309.40266 BP_3 139.90 1.14 6199 91078794 XP_970038.1 3616 0.0e+00 PREDICTED: WD repeat-containing protein 3 [Tribolium castaneum]>gi|270003730|gb|EFA00178.1| hypothetical protein TcasGA2_TC003001 [Tribolium castaneum] 642916054 XM_008192652.1 293 3.74166e-149 PREDICTED: Tribolium castaneum uncharacterized LOC100141824 (LOC100141824), transcript variant X3, mRNA K14556 DIP2, UTP12, WDR3 U3 small nucleolar RNA-associated protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14556 Q9UNX4 2070 1.5e-230 WD repeat-containing protein 3 OS=Homo sapiens GN=WDR3 PE=1 SV=1 PF04494//PF00008//PF00400 WD40 associated region in TFIID subunit, NTD2 domain//EGF-like domain//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.40267 BP_3 84.17 3.94 1321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40268 BP_3 44.00 3.54 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83653 182 1.9e-12 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.40271 BP_3 2035.93 15.12 6780 91088351 XP_971536.1 3641 0.0e+00 PREDICTED: ER degradation-enhancing alpha-mannosidase-like protein 3 [Tribolium castaneum] 642931619 XM_966443.2 359 0 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K10086 EDEM3 ER degradation enhancer, mannosidase alpha-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10086 Q9BZQ6 2083 5.3e-232 ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens GN=EDEM3 PE=1 SV=2 PF06662//PF00755//PF01532 D-glucuronyl C5-epimerase C-terminus//Choline/Carnitine o-acyltransferase//Glycosyl hydrolase family 47 GO:0005975//GO:0006024 carbohydrate metabolic process//glycosaminoglycan biosynthetic process GO:0005509//GO:0016857//GO:0004571//GO:0016746 calcium ion binding//racemase and epimerase activity, acting on carbohydrates and derivatives//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups GO:0016020//GO:0016021 membrane//integral component of membrane KOG2429 Glycosyl hydrolase, family 47 Cluster-8309.40272 BP_3 269.71 4.45 3216 478259304 ENN79206.1 1335 3.3e-144 hypothetical protein YQE_04390, partial [Dendroctonus ponderosae]>gi|546681746|gb|ERL91778.1| hypothetical protein D910_09104 [Dendroctonus ponderosae] 388519142 BT147839.1 36 1.41649e-06 Medicago truncatula clone JCVI-FLMt-9K12 unknown mRNA -- -- -- -- Q5R6C0 862 9.5e-91 Cell cycle control protein 50A OS=Pongo abelii GN=TMEM30A PE=2 SV=1 PF04103//PF03381 CD20-like family//LEM3 (ligand-effect modulator 3) family / CDC50 family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG2952 Cell cycle control protein Cluster-8309.40273 BP_3 642.29 10.42 3264 478259304 ENN79206.1 1335 3.3e-144 hypothetical protein YQE_04390, partial [Dendroctonus ponderosae]>gi|546681746|gb|ERL91778.1| hypothetical protein D910_09104 [Dendroctonus ponderosae] 388519142 BT147839.1 36 1.43787e-06 Medicago truncatula clone JCVI-FLMt-9K12 unknown mRNA -- -- -- -- Q5R6C0 862 9.7e-91 Cell cycle control protein 50A OS=Pongo abelii GN=TMEM30A PE=2 SV=1 PF03381//PF04103 LEM3 (ligand-effect modulator 3) family / CDC50 family//CD20-like family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG2952 Cell cycle control protein Cluster-8309.40274 BP_3 53.92 0.50 5479 642930363 XP_008196367.1 971 9.1e-102 PREDICTED: protein DEK isoform X3 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.86104e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.40275 BP_3 262.98 5.03 2810 150416589 ABF60888.2 211 6.2e-14 putative glycine-rich protein [Leptinotarsa decemlineata]>gi|157649942|gb|ABV59365.1| glycine-rich protein variant 2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40277 BP_3 1274.27 4.32 14515 478258629 ENN78679.1 7005 0.0e+00 hypothetical protein YQE_04851, partial [Dendroctonus ponderosae]>gi|546685785|gb|ERL95234.1| hypothetical protein D910_12501 [Dendroctonus ponderosae] 665784642 XM_008562939.1 48 1.37592e-12 PREDICTED: Microplitis demolitor synaptobrevin homolog YKT6 (LOC103580980), mRNA K05732 GRLF1 glucocorticoid receptor DNA-binding factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05732 Q9VX32 2839 0.0e+00 Rho GTPase-activating protein 190 OS=Drosophila melanogaster GN=RhoGAPp190 PE=1 SV=2 PF00071//PF01207//PF10403//PF08911//PF00957//PF00642//PF00620 Ras family//Dihydrouridine synthase (Dus)//Rad4 beta-hairpin domain 1//NUP50 (Nucleoporin 50 kDa)//Synaptobrevin//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//RhoGAP domain GO:0016192//GO:0007165//GO:0008033//GO:0007264//GO:0055114 vesicle-mediated transport//signal transduction//tRNA processing//small GTPase mediated signal transduction//oxidation-reduction process GO:0017150//GO:0003677//GO:0046872//GO:0050660//GO:0005525 tRNA dihydrouridine synthase activity//DNA binding//metal ion binding//flavin adenine dinucleotide binding//GTP binding GO:0016021//GO:0005643 integral component of membrane//nuclear pore KOG2333 Uncharacterized conserved protein Cluster-8309.40280 BP_3 1567.63 27.55 3034 642914511 XP_008201707.1 1442 1.2e-156 PREDICTED: protein scalloped isoform X2 [Tribolium castaneum] 642914510 XM_008203485.1 441 0 PREDICTED: Tribolium castaneum scalloped (LOC658922), transcript variant X2, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P28347 1085 1.2e-116 Transcriptional enhancer factor TEF-1 OS=Homo sapiens GN=TEAD1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.40281 BP_3 32.65 0.67 2654 728417098 AIY68333.1 930 2.5e-97 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 555 3.1e-55 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.40282 BP_3 34.34 0.32 5490 283046718 NP_001164305.1 2081 1.8e-230 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 432 0 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q91YT0 1897 1.6e-210 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus GN=Ndufv1 PE=1 SV=1 PF04177//PF10589 TAP42-like family//NADH-ubiquinone oxidoreductase-F iron-sulfur binding region GO:0006120//GO:0009966//GO:0006744//GO:0006814//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//regulation of signal transduction//ubiquinone biosynthetic process//sodium ion transport//proton transport//oxidation-reduction process GO:0010181//GO:0051287//GO:0008137//GO:0051539 FMN binding//NAD binding//NADH dehydrogenase (ubiquinone) activity//4 iron, 4 sulfur cluster binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.40283 BP_3 4193.08 124.66 1913 91080775 XP_968281.1 1628 2.1e-178 PREDICTED: rab GDP dissociation inhibitor alpha [Tribolium castaneum]>gi|270005439|gb|EFA01887.1| hypothetical protein TcasGA2_TC007497 [Tribolium castaneum] 299756048 XM_001829008.2 37 2.32659e-07 Coprinopsis cinerea okayama7#130 ### RAB GDP-dissociation inhibitor, mRNA K17255 GDI1_2 Rab GDP dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K17255 Q7YQM0 1125 1.8e-121 Rab GDP dissociation inhibitor alpha OS=Pongo pygmaeus GN=GDI1 PE=2 SV=1 -- -- GO:0015031 protein transport GO:0005093 Rab GDP-dissociation inhibitor activity -- -- KOG1439 RAB proteins geranylgeranyltransferase component A (RAB escort protein) Cluster-8309.40286 BP_3 838.93 80.03 797 270004092 EFA00540.1 592 1.2e-58 hypothetical protein TcasGA2_TC003405 [Tribolium castaneum] 827544782 XM_012689556.1 56 2.59205e-18 PREDICTED: Bombyx mori inorganic phosphate co-transporter (LOC100500932), transcript variant X2, mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 440 2.0e-42 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.40287 BP_3 949.34 7.27 6582 642914389 XP_008201657.1 2571 3.2e-287 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K08836 SLK STE20-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08836 O54988 1025 2.5e-109 STE20-like serine/threonine-protein kinase OS=Mus musculus GN=Slk PE=1 SV=2 PF07714//PF00069//PF12474 Protein tyrosine kinase//Protein kinase domain//Polo kinase kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.40288 BP_3 16.26 1.19 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40289 BP_3 23.00 3.31 627 91094995 XP_969089.1 192 2.2e-12 PREDICTED: 60S ribosomal protein L35a [Tribolium castaneum]>gi|642939753|ref|XP_008195720.1| PREDICTED: 60S ribosomal protein L35a [Tribolium castaneum]>gi|270015389|gb|EFA11837.1| hypothetical protein TcasGA2_TC002098 [Tribolium castaneum] -- -- -- -- -- K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 P49180 155 1.8e-09 60S ribosomal protein L35a OS=Caenorhabditis elegans GN=rpl-33 PE=1 SV=3 PF01782//PF01247 RimM N-terminal domain//Ribosomal protein L35Ae GO:0006364//GO:0042254//GO:0006412 rRNA processing//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-8309.40290 BP_3 1540.49 19.57 4086 91078730 XP_966316.1 1601 6.0e-175 PREDICTED: putative inorganic phosphate cotransporter isoform X1 [Tribolium castaneum] 642915952 XM_961223.3 285 6.88498e-145 PREDICTED: Tribolium castaneum putative inorganic phosphate cotransporter (LOC655821), transcript variant X1, mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 1253 5.6e-136 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00845//PF07690//PF00083//PF01907 Geminivirus BL1 movement protein//Major Facilitator Superfamily//Sugar (and other) transporter//Ribosomal protein L37e GO:0055085//GO:0006412//GO:0042254//GO:0046740 transmembrane transport//translation//ribosome biogenesis//transport of virus in host, cell to cell GO:0003677//GO:0022857//GO:0003735 DNA binding//transmembrane transporter activity//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622//GO:0033644 integral component of membrane//ribosome//intracellular//host cell membrane -- -- Cluster-8309.40291 BP_3 48.83 1.57 1795 478252836 ENN73225.1 1060 1.4e-112 hypothetical protein YQE_10122, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14102 Capsule biosynthesis CapC GO:0045227 capsule polysaccharide biosynthetic process -- -- GO:0016020 membrane -- -- Cluster-8309.40295 BP_3 118.74 6.65 1153 478250393 ENN70888.1 1026 8.0e-109 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 Q71SP7 829 2.3e-87 Fatty acid synthase OS=Bos taurus GN=FASN PE=2 SV=1 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.40296 BP_3 104.73 1.11 4822 546672885 ERL84608.1 3562 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1055 6.0e-113 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00108//PF08545//PF00107 Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Zinc-binding dehydrogenase GO:0008152//GO:0006633//GO:0042967//GO:0055114 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process//oxidation-reduction process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.403 BP_3 4.00 0.34 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40300 BP_3 101.44 2.41 2323 478260571 ENN80274.1 605 1.1e-59 hypothetical protein YQE_03268, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06872 EspG protein GO:0009405//GO:0006508 pathogenesis//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.40301 BP_3 1817.40 15.81 5833 642911463 XP_008199434.1 996 1.2e-104 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF15220//PF03323 MAP7 (E-MAP-115) family//Hypoxia-inducible lipid droplet-associated//Bacillus/Clostridium GerA spore germination protein GO:0010884//GO:0000226//GO:0001819//GO:0008284//GO:0009847 positive regulation of lipid storage//microtubule cytoskeleton organization//positive regulation of cytokine production//positive regulation of cell proliferation//spore germination -- -- GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane -- -- Cluster-8309.40303 BP_3 5457.05 168.25 1855 642934971 XP_008196003.1 1022 3.7e-108 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 142 9.63646e-66 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40304 BP_3 407.17 9.51 2355 642926608 XP_969412.2 812 1.1e-83 PREDICTED: histone-lysine N-methyltransferase pr-set7 [Tribolium castaneum] -- -- -- -- -- K11428 SETD8 histone-lysine N-methyltransferase SETD8 http://www.genome.jp/dbget-bin/www_bget?ko:K11428 Q9VFK6 626 1.6e-63 Histone-lysine N-methyltransferase pr-set7 OS=Drosophila melanogaster GN=pr-set7 PE=1 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1085 Predicted methyltransferase (contains a SET domain) Cluster-8309.40305 BP_3 709.14 10.85 3441 91085683 XP_972028.1 2028 1.5e-224 PREDICTED: nucleolar complex protein 3 homolog [Tribolium castaneum] -- -- -- -- -- K14834 NOC3 nucleolar complex protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14834 Q9VI82 1119 1.6e-120 Nucleolar complex protein 3 homolog OS=Drosophila melanogaster GN=CG1234 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2153 Protein involved in the nuclear export of pre-ribosomes Cluster-8309.40306 BP_3 37.27 0.44 4345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40307 BP_3 112.71 1.00 5723 642931601 XP_008196651.1 4639 0.0e+00 PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum]>gi|642931603|ref|XP_008196652.1| PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum] 723941700 KF986386.1 853 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3318 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF04810//PF02171//PF02170 Sec23/Sec24 zinc finger//Piwi domain//PAZ domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003676//GO:0008270 protein binding//nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.40309 BP_3 12783.43 62.63 10129 478254521 ENN74767.1 2343 1.4e-260 hypothetical protein YQE_08655, partial [Dendroctonus ponderosae] 332374221 BT127290.1 561 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA -- -- -- -- O16011 733 2.7e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF01607//PF00057//PF00642//PF03176//PF01522 Chitin binding Peritrophin-A domain//Low-density lipoprotein receptor domain class A//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//MMPL family//Polysaccharide deacetylase GO:0006030//GO:0005975//GO:0006807 chitin metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0005515//GO:0046872//GO:0008061//GO:0016810 protein binding//metal ion binding//chitin binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016020//GO:0005576 membrane//extracellular region KOG2494 C3H1-type Zn-finger protein Cluster-8309.40311 BP_3 127.22 2.80 2479 91088135 XP_970927.1 2676 8.1e-300 PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum]>gi|642931216|ref|XP_008196487.1| PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum] -- -- -- -- -- K14015 NPLOC4, NPL4 nuclear protein localization protein 4 homolog http://www.genome.jp/dbget-bin/www_bget?ko:K14015 Q9VBP9 1976 4.9e-220 Nuclear protein localization protein 4 homolog OS=Drosophila melanogaster GN=Npl4 PE=1 SV=3 PF00641//PF02565 Zn-finger in Ran binding protein and others//Recombination protein O C terminal GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0008270 zinc ion binding -- -- KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4) Cluster-8309.40312 BP_3 382.07 4.22 4653 642916561 XP_008191701.1 1795 2.2e-197 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U0L2 302 1.2e-25 Ankyrin repeat domain-containing protein 33B OS=Mus musculus GN=Ankrd33b PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40315 BP_3 75.44 1.58 2586 642928001 XP_008195479.1 4205 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] 642928000 XM_008197257.1 930 0 PREDICTED: Tribolium castaneum neurexin-1 (LOC663759), mRNA K07377 NRXN neurexin http://www.genome.jp/dbget-bin/www_bget?ko:K07377 A1XQX0 1725 6.5e-191 Neurexin-1a OS=Danio rerio GN=nrxn1a PE=2 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.40317 BP_3 77.74 0.81 4933 642925814 XP_970128.3 565 9.8e-55 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 400 5.5e-37 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF02737//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0006574//GO:0006550//GO:0008152//GO:0006633//GO:0018874//GO:0006568//GO:0006631//GO:0006552//GO:0006554//GO:0055114 valine catabolic process//isoleucine catabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//tryptophan metabolic process//fatty acid metabolic process//leucine catabolic process//lysine catabolic process//oxidation-reduction process GO:0003824//GO:0050662//GO:0016491//GO:0003857 catalytic activity//coenzyme binding//oxidoreductase activity//3-hydroxyacyl-CoA dehydrogenase activity -- -- -- -- Cluster-8309.40318 BP_3 453.57 30.95 998 642920912 XP_008192612.1 755 1.8e-77 PREDICTED: outer dense fiber protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 271 1.0e-22 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40319 BP_3 28.32 0.59 2591 642923353 XP_008193715.1 1609 4.5e-176 PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q80VJ4 486 3.1e-47 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Rattus norvegicus GN=Gpcpd1 PE=2 SV=1 PF03009//PF00686 Glycerophosphoryl diester phosphodiesterase family//Starch binding domain GO:0006629 lipid metabolic process GO:0008081//GO:2001070 phosphoric diester hydrolase activity//starch binding -- -- KOG2421 Predicted starch-binding protein Cluster-8309.40320 BP_3 689.02 9.79 3683 642923778 XP_008193880.1 633 9.5e-63 PREDICTED: zinc finger protein 395 isoform X1 [Tribolium castaneum] 170064362 XM_001867459.1 65 1.22945e-22 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- P04323 300 1.6e-25 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00536//PF08541//PF01416 SAM domain (Sterile alpha motif)//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//tRNA pseudouridine synthase GO:0001522//GO:0009451//GO:0008610 pseudouridine synthesis//RNA modification//lipid biosynthetic process GO:0016747//GO:0005515//GO:0009982//GO:0003723 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//pseudouridine synthase activity//RNA binding -- -- -- -- Cluster-8309.40323 BP_3 2123.70 60.56 1982 91076308 XP_969307.1 2397 1.5e-267 PREDICTED: furin-like protease 2 [Tribolium castaneum] 817211511 XM_012426473.1 452 0 PREDICTED: Orussus abietinus furin-like protease 2 (LOC105700544), mRNA K08672 PCSK6 proprotein convertase subtilisin/kexin type 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08672 P30432 2093 1.1e-233 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3525 Subtilisin-like proprotein convertase Cluster-8309.40325 BP_3 519.09 11.14 2538 189234632 XP_001815875.1 1328 1.7e-143 PREDICTED: uncharacterized protein LOC100141793 [Tribolium castaneum]>gi|270002124|gb|EEZ98571.1| hypothetical protein TcasGA2_TC001083 [Tribolium castaneum] 645023008 XM_003425366.2 61 1.4124e-20 PREDICTED: Nasonia vitripennis uncharacterized LOC100678221 (LOC100678221), transcript variant X13, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40329 BP_3 1176.97 11.62 5174 831511189 XP_012714153.1 456 4.5e-42 PREDICTED: zinc finger protein 345-like [Fundulus heteroclitus] -- -- -- -- -- -- -- -- -- Q9NYT6 434 6.5e-41 Zinc finger protein 226 OS=Homo sapiens GN=ZNF226 PE=2 SV=2 PF16622//PF05485//PF07776//PF02892//PF13912//PF13465//PF00096 zinc-finger C2H2-type//THAP domain//Zinc-finger associated domain (zf-AD)//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677//GO:0003676//GO:0008270 metal ion binding//DNA binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.40331 BP_3 432.13 3.70 5920 189237914 XP_969710.2 1573 1.5e-171 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.55524e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 1.0e-114 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13499//PF13833//PF10591//PF13405//PF02022//PF08332//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Integrase Zinc binding domain//Calcium/calmodulin dependent protein kinase II association domain//EF hand//EF hand GO:0009069//GO:0006468//GO:0016310//GO:0007165 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//signal transduction GO:0004683//GO:0005516//GO:0008270//GO:0005509 calmodulin-dependent protein kinase activity//calmodulin binding//zinc ion binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.40334 BP_3 225.51 2.07 5536 189237914 XP_969710.2 1467 2.8e-159 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.45374e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 9.6e-115 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13202//PF10591//PF13833//PF13405//PF00036//PF13499//PF08332 EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//Calcium/calmodulin dependent protein kinase II association domain GO:0009069//GO:0006468//GO:0016310//GO:0007165 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//signal transduction GO:0005509//GO:0004683//GO:0005516 calcium ion binding//calmodulin-dependent protein kinase activity//calmodulin binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.40335 BP_3 77.21 0.63 6226 189237914 XP_969710.2 1573 1.6e-171 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.63612e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 1.1e-114 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13202//PF08332//PF00036//PF02022//PF13499//PF10591//PF13833//PF13405 EF hand//Calcium/calmodulin dependent protein kinase II association domain//EF hand//Integrase Zinc binding domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0006468//GO:0009069//GO:0016310//GO:0007165 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//signal transduction GO:0005509//GO:0008270//GO:0004683//GO:0005516 calcium ion binding//zinc ion binding//calmodulin-dependent protein kinase activity//calmodulin binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.40337 BP_3 234.53 5.50 2348 478258505 ENN78580.1 1100 4.3e-117 hypothetical protein YQE_04948, partial [Dendroctonus ponderosae]>gi|546681354|gb|ERL91464.1| hypothetical protein D910_08794 [Dendroctonus ponderosae] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q5VTE6 611 8.9e-62 Protein angel homolog 2 OS=Homo sapiens GN=ANGEL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.40338 BP_3 12.57 0.33 2117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40339 BP_3 60.06 0.47 6467 189236151 XP_974913.2 6297 0.0e+00 PREDICTED: tyrosine-protein phosphatase 10D isoform X3 [Tribolium castaneum] 687022658 LM525572.1 65 2.16695e-22 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_scaffold0000013 K05694 PTPRB, PTPB receptor-type tyrosine-protein phosphatase beta http://www.genome.jp/dbget-bin/www_bget?ko:K05694 P35992 5174 0.0e+00 Tyrosine-protein phosphatase 10D OS=Drosophila melanogaster GN=Ptp10D PE=1 SV=4 PF00782//PF16794//PF00041//PF00102//PF16656 Dual specificity phosphatase, catalytic domain//Fibronectin-III type domain//Fibronectin type III domain//Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain GO:0006570//GO:0006470//GO:0019497//GO:0006771 tyrosine metabolic process//protein dephosphorylation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0008138//GO:0004725//GO:0046872//GO:0003993 protein binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//metal ion binding//acid phosphatase activity -- -- KOG0791 Protein tyrosine phosphatase, contains fn3 domain Cluster-8309.4034 BP_3 17.89 0.93 1222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40340 BP_3 15674.14 174.67 4617 86515394 NP_001034522.1 2216 3.3e-246 pro-phenol oxidase subunit 2 [Tribolium castaneum]>gi|70999576|gb|AAX84205.1| pro-phenol oxidase subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V521 1934 6.8e-215 Phenoloxidase 2 OS=Drosophila melanogaster GN=PPO2 PE=1 SV=1 PF00264 Common central domain of tyrosinase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.40341 BP_3 49.00 0.78 3323 91085397 XP_966819.1 1555 1.1e-169 PREDICTED: growth/differentiation factor 8 [Tribolium castaneum]>gi|270009305|gb|EFA05753.1| myoglianin [Tribolium castaneum] 642926716 XM_961726.2 350 0 PREDICTED: Tribolium castaneum myoglianin (LOC655210), mRNA K05497 GDF8_11 growth differentiation factor 8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K05497 Q9Z1W4 622 6.7e-63 Growth/differentiation factor 11 OS=Mus musculus GN=Gdf11 PE=2 SV=1 PF00019//PF00688//PF10538 Transforming growth factor beta like domain//TGF-beta propeptide//Immunoreceptor tyrosine-based activation motif GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity GO:0005576 extracellular region KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.40342 BP_3 151.18 0.85 8831 646710408 KDR15927.1 1192 3.5e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.70322e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 PF11561 Single strand annealing-weakened 1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends GO:0070336 flap-structured DNA binding -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.40343 BP_3 16054.31 147.95 5522 478250929 ENN71414.1 1135 8.8e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.21528e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF00852//PF00956//PF04889//PF03606 Glycosyltransferase family 10 (fucosyltransferase) C-term//Nucleosome assembly protein (NAP)//Cwf15/Cwc15 cell cycle control protein//C4-dicarboxylate anaerobic carrier GO:0006486//GO:0000398//GO:0006334 protein glycosylation//mRNA splicing, via spliceosome//nucleosome assembly GO:0008417 fucosyltransferase activity GO:0016020//GO:0005634//GO:0016021//GO:0005681 membrane//nucleus//integral component of membrane//spliceosomal complex KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.40346 BP_3 1028.00 10.37 5071 91090089 XP_975854.1 533 5.2e-51 PREDICTED: protein Tob1 [Tribolium castaneum]>gi|270013495|gb|EFA09943.1| hypothetical protein TcasGA2_TC012096 [Tribolium castaneum] 642934619 XM_970761.2 234 1.91951e-116 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 -- -- -- -- PF01339 CheB methylesterase GO:0000160//GO:0006935 phosphorelay signal transduction system//chemotaxis GO:0008984//GO:0000156 protein-glutamate methylesterase activity//phosphorelay response regulator activity GO:0005737 cytoplasm -- -- Cluster-8309.40347 BP_3 2420.09 13.97 8642 746835597 XP_011068495.1 2501 5.5e-279 PREDICTED: uncharacterized protein LOC105154570 isoform X8 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q62417 536 1.6e-52 Sorbin and SH3 domain-containing protein 1 OS=Mus musculus GN=Sorbs1 PE=1 SV=2 PF12549//PF14604//PF00383//PF00018 Tyrosine hydroxylase N terminal//Variant SH3 domain//Cytidine and deoxycytidylate deaminase zinc-binding region//SH3 domain GO:0055114//GO:0006570 oxidation-reduction process//tyrosine metabolic process GO:0008270//GO:0004511//GO:0005515 zinc ion binding//tyrosine 3-monooxygenase activity//protein binding -- -- KOG4225 Sorbin and SH3 domain-containing protein Cluster-8309.40348 BP_3 100.88 1.17 4453 478254003 ENN74295.1 1276 3.2e-137 hypothetical protein YQE_09267, partial [Dendroctonus ponderosae]>gi|546673725|gb|ERL85281.1| hypothetical protein D910_02702 [Dendroctonus ponderosae] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 P13280 850 3.3e-89 Glycogenin-1 OS=Oryctolagus cuniculus GN=GYG1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.40351 BP_3 4921.71 138.06 2010 332373698 AEE61990.1 2442 8.9e-273 unknown [Dendroctonus ponderosae] 630581065 KF383704.1 194 1.2965e-94 Tectarchus salebrosus isolate TES phosphoglucose isomerase (Pgi) mRNA, Pgi-1 allele, partial cds K01810 GPI, pgi glucose-6-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01810 P52031 2165 4.8e-242 Glucose-6-phosphate isomerase OS=Drosophila yakuba GN=Pgi PE=3 SV=1 PF11593//PF02792//PF00342 Mediator complex subunit 3 fungal//Mago nashi protein//Phosphoglucose isomerase GO:0006096//GO:0005982//GO:0006098//GO:0005985//GO:0006094//GO:0006357 glycolytic process//starch metabolic process//pentose-phosphate shunt//sucrose metabolic process//gluconeogenesis//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0004347 RNA polymerase II transcription cofactor activity//glucose-6-phosphate isomerase activity GO:0005634//GO:0016592 nucleus//mediator complex KOG2446 Glucose-6-phosphate isomerase Cluster-8309.40352 BP_3 2605.21 64.12 2250 189234454 XP_967960.2 2239 3.5e-249 PREDICTED: aldehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270002022|gb|EEZ98469.1| hypothetical protein TcasGA2_TC000960 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11884 1751 5.5e-194 Aldehyde dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Aldh2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016620//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.40355 BP_3 2.00 0.64 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00283 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits GO:0015979 photosynthesis -- -- -- -- -- -- Cluster-8309.40361 BP_3 1706.86 33.10 2777 270016295 EFA12741.1 1301 2.5e-140 Rm62 [Tribolium castaneum] 194745413 XM_001955147.1 238 6.24472e-119 Drosophila ananassae GF18634 (Dana\GF18634), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1121 7.6e-121 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0016787//GO:0003677//GO:0003676//GO:0005524 hydrolase activity//DNA binding//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.40362 BP_3 325.34 4.07 4148 270015108 EFA11556.1 1793 3.3e-197 plexin B [Tribolium castaneum] 642910642 XM_008201819.1 310 8.85273e-159 PREDICTED: Tribolium castaneum plexin-B (LOC656639), mRNA -- -- -- -- Q9V4A7 1057 3.0e-113 Plexin-B OS=Drosophila melanogaster GN=plexB PE=1 SV=2 PF00293//PF01403//PF02600 NUDIX domain//Sema domain//Disulfide bond formation protein DsbB GO:0006118 obsolete electron transport GO:0015035//GO:0016787//GO:0005515 protein disulfide oxidoreductase activity//hydrolase activity//protein binding GO:0016020 membrane KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.40363 BP_3 203.66 2.60 4065 270015108 EFA11556.1 1793 3.2e-197 plexin B [Tribolium castaneum] 642910642 XM_008201819.1 310 8.67404e-159 PREDICTED: Tribolium castaneum plexin-B (LOC656639), mRNA -- -- -- -- Q9V4A7 1057 2.9e-113 Plexin-B OS=Drosophila melanogaster GN=plexB PE=1 SV=2 PF01403//PF02600//PF00293 Sema domain//Disulfide bond formation protein DsbB//NUDIX domain GO:0006118 obsolete electron transport GO:0005515//GO:0016787//GO:0015035 protein binding//hydrolase activity//protein disulfide oxidoreductase activity GO:0016020 membrane KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.40364 BP_3 3825.74 19.54 9731 642910643 XP_008200041.1 6865 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: plexin-B [Tribolium castaneum] 571537979 XM_395735.5 266 6.00975e-134 PREDICTED: Apis mellifera plexin B (plexB), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 Q9V4A7 4832 0.0e+00 Plexin-B OS=Drosophila melanogaster GN=plexB PE=1 SV=2 PF01833//PF01756//PF04414//PF01403//PF00441//PF02770//PF01437 IPT/TIG domain//Acyl-CoA oxidase//D-aminoacyl-tRNA deacylase//Sema domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Plexin repeat GO:0006118//GO:0055114//GO:0006637//GO:0006635 obsolete electron transport//oxidation-reduction process//acyl-CoA metabolic process//fatty acid beta-oxidation GO:0003997//GO:0051499//GO:0016627//GO:0003995//GO:0016788//GO:0005515 acyl-CoA oxidase activity//D-aminoacyl-tRNA deacylase activity//oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA dehydrogenase activity//hydrolase activity, acting on ester bonds//protein binding GO:0016020//GO:0005777 membrane//peroxisome KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.40366 BP_3 821.29 6.88 6048 642924598 XP_008194358.1 2026 4.6e-224 PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924600|ref|XP_008194359.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924602|ref|XP_008194360.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum] 827557233 XM_012694434.1 87 1.19415e-34 PREDICTED: Bombyx mori Rho-associated protein kinase (rock1), transcript variant X1, mRNA K17388 ROCK2 Rho-associated protein kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17388 M3TYT0 1033 2.7e-110 Rho-associated protein kinase 2 OS=Sus scrofa GN=ROCK2 PE=1 SV=1 PF00130//PF08912//PF01420//PF00769//PF04513 Phorbol esters/diacylglycerol binding domain (C1 domain)//Rho Binding//Type I restriction modification DNA specificity domain//Ezrin/radixin/moesin family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0035556//GO:0006304 intracellular signal transduction//DNA modification GO:0005198//GO:0008092//GO:0003677//GO:0017048 structural molecule activity//cytoskeletal protein binding//DNA binding//Rho GTPase binding GO:0019031//GO:0019028//GO:0019898//GO:0005737 viral envelope//viral capsid//extrinsic component of membrane//cytoplasm KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.40367 BP_3 3.00 2.03 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40368 BP_3 173.00 121.45 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40370 BP_3 409.59 1.91 10613 91084143 XP_970053.1 5407 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X2 [Tribolium castaneum]>gi|270006644|gb|EFA03092.1| hypothetical protein TcasGA2_TC013000 [Tribolium castaneum] 642925099 XM_964960.2 890 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9LV03 3249 0.0e+00 Glutamate synthase 1 [NADH], chloroplastic OS=Arabidopsis thaliana GN=GLT1 PE=2 SV=2 PF00070//PF01493//PF01210//PF01266//PF01645//PF04183//PF01593//PF12831//PF00743//PF04898//PF01070//PF00869//PF01134//PF05834//PF13241//PF00833//PF07992//PF00287//PF01494 Pyridine nucleotide-disulphide oxidoreductase//GXGXG motif//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//FAD dependent oxidoreductase//Conserved region in glutamate synthase//IucA / IucC family//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Flavin-binding monooxygenase-like//Glutamate synthase central domain//FMN-dependent dehydrogenase//Flavivirus glycoprotein, central and dimerisation domains//Glucose inhibited division protein A//Lycopene cyclase protein//Putative NAD(P)-binding//Ribosomal S17//Pyridine nucleotide-disulphide oxidoreductase//Sodium / potassium ATPase beta chain//FAD binding domain GO:0019354//GO:0008152//GO:0046168//GO:0016117//GO:0019290//GO:0006814//GO:0006118//GO:0055114//GO:0042254//GO:0006779//GO:0006813//GO:0006412//GO:0006807//GO:0006537//GO:0006826//GO:0008033 siroheme biosynthetic process//metabolic process//glycerol-3-phosphate catabolic process//carotenoid biosynthetic process//siderophore biosynthetic process//sodium ion transport//obsolete electron transport//oxidation-reduction process//ribosome biogenesis//porphyrin-containing compound biosynthetic process//potassium ion transport//translation//nitrogen compound metabolic process//glutamate biosynthetic process//iron ion transport//tRNA processing GO:0043115//GO:0046983//GO:0016491//GO:0015930//GO:0010181//GO:0016616//GO:0003735//GO:0005506//GO:0016705//GO:0050661//GO:0004499//GO:0051287//GO:0016040//GO:0050660//GO:0071949//GO:0015343//GO:0051536//GO:0016638 precorrin-2 dehydrogenase activity//protein dimerization activity//oxidoreductase activity//glutamate synthase activity//FMN binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural constituent of ribosome//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//NADP binding//N,N-dimethylaniline monooxygenase activity//NAD binding//glutamate synthase (NADH) activity//flavin adenine dinucleotide binding//FAD binding//siderophore transmembrane transporter activity//iron-sulfur cluster binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0005890//GO:0005840//GO:0005622 sodium:potassium-exchanging ATPase complex//ribosome//intracellular KOG0399 Glutamate synthase Cluster-8309.40371 BP_3 151.10 2.70 2989 91090214 XP_967924.1 1528 1.3e-166 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 652 2.0e-66 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.40373 BP_3 84.09 0.69 6129 642937896 XP_008200347.1 2525 6.5e-282 PREDICTED: protein vav isoform X1 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 1468 9.8e-161 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF00621//PF00018//PF14604//PF00307//PF00130 RhoGEF domain//SH3 domain//Variant SH3 domain//Calponin homology (CH) domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035023//GO:0043087//GO:0035556 regulation of Rho protein signal transduction//regulation of GTPase activity//intracellular signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.40374 BP_3 717.86 5.59 6486 642914186 XP_008201580.1 1615 2.3e-176 PREDICTED: uncharacterized protein LOC661670 isoform X1 [Tribolium castaneum]>gi|270002176|gb|EEZ98623.1| hypothetical protein TcasGA2_TC001146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40375 BP_3 526.00 14.57 2032 478256698 ENN76880.1 1470 4.6e-160 hypothetical protein YQE_06721, partial [Dendroctonus ponderosae] 642911481 XM_968458.3 125 2.98175e-56 PREDICTED: Tribolium castaneum protein BCL9 homolog (LOC662357), mRNA -- -- -- -- Q961D9 203 1.6e-14 Protein BCL9 homolog OS=Drosophila melanogaster GN=lgs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40376 BP_3 173.12 2.54 3581 91076812 XP_974369.1 922 2.8e-96 PREDICTED: Krueppel-like factor 13 [Tribolium castaneum]>gi|270001931|gb|EEZ98378.1| hypothetical protein TcasGA2_TC000837 [Tribolium castaneum] 667677333 AE014297.3 36 1.57907e-06 Drosophila melanogaster chromosome 3R K09208 KLF9S, BTEB krueppel-like factor 9/13/14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K09208 Q9Y2Y9 418 3.2e-39 Krueppel-like factor 13 OS=Homo sapiens GN=KLF13 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40377 BP_3 770.89 9.39 4247 642938734 XP_967034.2 3818 0.0e+00 PREDICTED: integrator complex subunit 3 homolog [Tribolium castaneum] -- -- -- -- -- K13140 INTS3 integrator complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13140 Q7PRB8 2253 6.4e-252 Integrator complex subunit 3 homolog OS=Anopheles gambiae GN=AGAP002539 PE=3 SV=5 -- -- -- -- -- -- -- -- KOG4262 Uncharacterized conserved protein Cluster-8309.40378 BP_3 2242.78 42.34 2845 642930416 XP_008196392.1 623 1.1e-61 PREDICTED: stAR-related lipid transfer protein 3 [Tribolium castaneum]>gi|270011106|gb|EFA07554.1| Start1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DFS4 333 1.9e-29 StAR-related lipid transfer protein 3 OS=Danio rerio GN=stard3 PE=2 SV=2 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG3845 MLN, STAR and related lipid-binding proteins Cluster-8309.40379 BP_3 319.20 6.84 2542 478250613 ENN71105.1 2284 2.4e-254 hypothetical protein YQE_12038, partial [Dendroctonus ponderosae]>gi|546673107|gb|ERL84776.1| hypothetical protein D910_02201 [Dendroctonus ponderosae] -- -- -- -- -- K06058 DTX deltex http://www.genome.jp/dbget-bin/www_bget?ko:K06058 Q8R3P2 649 3.8e-66 Probable E3 ubiquitin-protein ligase DTX2 OS=Mus musculus GN=Dtx2 PE=1 SV=2 PF00628//PF14634//PF17123//PF12678//PF00097//PF17122//PF13639//PF12861 PHD-finger//zinc-RING finger domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.40381 BP_3 9.00 2.42 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40382 BP_3 799.49 6.25 6462 642915533 XP_008190655.1 1572 2.2e-171 PREDICTED: tyrosine-protein phosphatase non-receptor type 61F isoform X1 [Tribolium castaneum] -- -- -- -- -- K18026 PTPN2, PTPT tyrosine-protein phosphatase non-receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18026 Q9W0G1 859 4.3e-90 Tyrosine-protein phosphatase non-receptor type 61F OS=Drosophila melanogaster GN=Ptp61F PE=1 SV=1 PF03119//PF00102//PF00782//PF01396//PF08043//PF03248 NAD-dependent DNA ligase C4 zinc finger domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Topoisomerase DNA binding C4 zinc finger//Xin repeat//Rer1 family GO:0006260//GO:0006265//GO:0030036//GO:0006281//GO:0006470//GO:0006570 DNA replication//DNA topological change//actin cytoskeleton organization//DNA repair//protein dephosphorylation//tyrosine metabolic process GO:0003677//GO:0003911//GO:0004725//GO:0008138//GO:0003779//GO:0003916 DNA binding//DNA ligase (NAD+) activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//actin binding//DNA topoisomerase activity GO:0005694//GO:0030054//GO:0016021 chromosome//cell junction//integral component of membrane -- -- Cluster-8309.40383 BP_3 253.17 4.94 2761 642921053 XP_008192672.1 2472 4.1e-276 PREDICTED: serine/threonine-protein phosphatase rdgC [Tribolium castaneum] -- -- -- -- -- K13807 PPEF, PPP7C serine/threonine-protein phosphatase with EF-hands http://www.genome.jp/dbget-bin/www_bget?ko:K13807 P40421 1663 1.1e-183 Serine/threonine-protein phosphatase rdgC OS=Drosophila melanogaster GN=rdgC PE=2 SV=1 PF12763//PF00612//PF13499//PF13405//PF10591//PF13833//PF13202//PF00149//PF00036 Cytoskeletal-regulatory complex EF hand//IQ calmodulin-binding motif//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//Calcineurin-like phosphoesterase//EF hand GO:0007165 signal transduction GO:0005509//GO:0016787//GO:0005515 calcium ion binding//hydrolase activity//protein binding GO:0005578 proteinaceous extracellular matrix KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.40386 BP_3 155.38 0.82 9391 642935329 XP_008197970.1 2533 1.2e-282 PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum] 642935330 XM_008199749.1 821 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC656292), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q80ZD1 950 1.7e-100 Regulator of G-protein signaling 9 OS=Tamias striatus PE=1 SV=1 PF00424//PF00631//PF09128//PF00610 REV protein (anti-repression trans-activator protein)//GGL domain//Regulator of G protein signalling-like domain//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0007165//GO:0007186//GO:0006355//GO:0043087//GO:0035556 signal transduction//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//regulation of GTPase activity//intracellular signal transduction GO:0004871//GO:0005089//GO:0003700 signal transducer activity//Rho guanyl-nucleotide exchange factor activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667//GO:0005834//GO:0005737 host cell nucleus//transcription factor complex//heterotrimeric G-protein complex//cytoplasm KOG3589 G protein signaling regulators Cluster-8309.40387 BP_3 361.74 6.95 2801 642910948 XP_008193477.1 1852 3.2e-204 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 P23687 1214 1.3e-131 Prolyl endopeptidase OS=Sus scrofa GN=PREP PE=1 SV=1 PF00326//PF02897 Prolyl oligopeptidase family//Prolyl oligopeptidase, N-terminal beta-propeller domain GO:0006508 proteolysis GO:0008236//GO:0004252//GO:0070008 serine-type peptidase activity//serine-type endopeptidase activity//serine-type exopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.40389 BP_3 75.19 1.94 2159 189237054 XP_966641.2 758 1.8e-77 PREDICTED: bcl-2-related ovarian killer protein [Tribolium castaneum]>gi|270007277|gb|EFA03725.1| hypothetical protein TcasGA2_TC013830 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I8I2 201 2.8e-14 Bcl-2-related ovarian killer protein OS=Gallus gallus GN=BOK PE=2 SV=1 PF00452//PF14489 Apoptosis regulator proteins, Bcl-2 family//QueF-like protein GO:0008616//GO:0042981 queuosine biosynthetic process//regulation of apoptotic process GO:0033739 preQ1 synthase activity -- -- -- -- Cluster-8309.40390 BP_3 53.27 0.43 6277 91094947 XP_968721.1 2301 6.2e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF06815//PF02295//PF09606 Reverse transcriptase connection domain//Adenosine deaminase z-alpha domain//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006807//GO:0006357//GO:0006278 nitrogen compound metabolic process//regulation of transcription from RNA polymerase II promoter//RNA-dependent DNA replication GO:0003726//GO:0003723//GO:0001104//GO:0003964 double-stranded RNA adenosine deaminase activity//RNA binding//RNA polymerase II transcription cofactor activity//RNA-directed DNA polymerase activity GO:0016592 mediator complex KOG2432 Uncharacterized conserved protein Cluster-8309.40391 BP_3 1394.63 24.91 2990 478251374 ENN71840.1 3372 0.0e+00 hypothetical protein YQE_11459, partial [Dendroctonus ponderosae] 642926047 XM_964823.2 392 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2568 1.3e-288 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain GO:0008152//GO:0009058//GO:0055114 metabolic process//biosynthetic process//oxidation-reduction process GO:0016742//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.40394 BP_3 3930.20 111.09 1997 91082535 XP_973659.1 1816 3.4e-200 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270007558|gb|EFA04006.1| hypothetical protein TcasGA2_TC014155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 787 2.9e-82 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083//PF07578//PF08573 Major Facilitator Superfamily//Sugar (and other) transporter//Lipid A Biosynthesis N-terminal domain//DNA repair protein endonuclease SAE2/CtIP C-terminus GO:0006308//GO:0000077//GO:0006281//GO:0009245//GO:0055085 DNA catabolic process//DNA damage checkpoint//DNA repair//lipid A biosynthetic process//transmembrane transport GO:0000014//GO:0008915//GO:0022857 single-stranded DNA endodeoxyribonuclease activity//lipid-A-disaccharide synthase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.40395 BP_3 929.46 22.62 2272 373842654 AEY77316.1 404 2.1e-36 extracellular Cu/Zn-superoxide dismutase [Phaedon cochleariae] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P24704 315 1.8e-27 Superoxide dismutase [Cu-Zn] 1 OS=Arabidopsis thaliana GN=CSD1 PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.40396 BP_3 756.18 9.94 3960 642917882 XP_008191369.1 1010 2.0e-106 PREDICTED: uncharacterized protein LOC103312469 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64322 300 1.7e-25 Neural proliferation differentiation and control protein 1 OS=Mus musculus GN=Npdc1 PE=2 SV=2 PF06809 Neural proliferation differentiation control-1 protein (NPDC1) -- -- -- -- GO:0016021 integral component of membrane KOG3884 Neural proliferation, differentiation and control protein Cluster-8309.40399 BP_3 514.17 10.55 2640 546682278 ERL92239.1 2240 3.1e-249 hypothetical protein D910_09556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 245 2.7e-19 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF00452//PF07926 Apoptosis regulator proteins, Bcl-2 family//TPR/MLP1/MLP2-like protein GO:0042981//GO:0006606 regulation of apoptotic process//protein import into nucleus -- -- -- -- -- -- Cluster-8309.404 BP_3 12.00 1.71 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02979//PF05159//PF03286 Nitrile hydratase, alpha chain//Capsule polysaccharide biosynthesis protein//Pox virus Ag35 surface protein GO:0006807//GO:0015774//GO:0000271 nitrogen compound metabolic process//polysaccharide transport//polysaccharide biosynthetic process GO:0046914//GO:0003824 transition metal ion binding//catalytic activity GO:0019031 viral envelope -- -- Cluster-8309.40401 BP_3 672.98 24.38 1622 642920110 XP_008192209.1 602 1.6e-59 PREDICTED: putative oxidoreductase GLYR1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q161 532 8.9e-53 Putative oxidoreductase GLYR1 homolog OS=Anopheles gambiae GN=AGAP009949 PE=3 SV=5 PF02737//PF05051//PF14833//PF13241//PF03435//PF01210//PF02558//PF02826//PF03446 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Cytochrome C oxidase copper chaperone (COX17)//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006552//GO:0006631//GO:0046168//GO:0019354//GO:0006633//GO:0018874//GO:0006098//GO:0006779//GO:0006554//GO:0055114//GO:0019521//GO:0006568//GO:0006825//GO:0015940//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//glycerol-3-phosphate catabolic process//siroheme biosynthetic process//fatty acid biosynthetic process//benzoate metabolic process//pentose-phosphate shunt//porphyrin-containing compound biosynthetic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process//copper ion transport//pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process GO:0008677//GO:0016491//GO:0051287//GO:0005507//GO:0043115//GO:0016531//GO:0004616//GO:0003857//GO:0016616 2-dehydropantoate 2-reductase activity//oxidoreductase activity//NAD binding//copper ion binding//precorrin-2 dehydrogenase activity//copper chaperone activity//phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005758 mitochondrial intermembrane space KOG0409 Predicted dehydrogenase Cluster-8309.40402 BP_3 30.38 5.36 565 270004866 EFA01314.1 177 1.1e-10 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0A8J8 142 5.2e-08 Angiopoietin-2 OS=Canis familiaris GN=ANGPT2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40404 BP_3 195.64 20.09 761 270004866 EFA01314.1 634 1.5e-63 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 452 7.9e-44 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40406 BP_3 591.01 18.20 1857 270010830 EFA07278.1 1126 3.3e-120 hypothetical protein TcasGA2_TC014512 [Tribolium castaneum] 299884466 FP926002.1 78 3.64585e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51023 606 2.7e-61 ETS-like protein pointed, isoform P2/D OS=Drosophila melanogaster GN=pnt PE=2 SV=2 PF00447//PF00178 HSF-type DNA-binding//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.40407 BP_3 735.47 3.66 9968 642912029 XP_008199066.1 3032 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 468 1.4e-44 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF00873//PF04319//PF02460//PF03176 AcrB/AcrD/AcrF family//NifZ domain//Patched family//MMPL family GO:0006810//GO:0009399//GO:0007165 transport//nitrogen fixation//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.40408 BP_3 4.65 2.22 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40411 BP_3 2.00 0.42 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40416 BP_3 476.00 5.10 4786 478251184 ENN71660.1 1199 2.9e-128 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K02330 POLB DNA polymerase beta http://www.genome.jp/dbget-bin/www_bget?ko:K02330 O57383 937 2.9e-99 DNA polymerase beta OS=Xenopus laevis GN=polb PE=1 SV=3 PF01909//PF00633//PF01367//PF10391//PF00328 Nucleotidyltransferase domain//Helix-hairpin-helix motif//5'-3' exonuclease, C-terminal SAM fold//Fingers domain of DNA polymerase lambda//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0034061//GO:0003677//GO:0003824//GO:0016779//GO:0003993 DNA polymerase activity//DNA binding//catalytic activity//nucleotidyltransferase activity//acid phosphatase activity GO:0005634 nucleus -- -- Cluster-8309.40418 BP_3 415.91 2.79 7472 642929587 XP_975389.2 4335 0.0e+00 PREDICTED: uncharacterized protein LOC664289 isoform X3 [Tribolium castaneum] 642929586 XM_970296.2 70 4.16326e-25 PREDICTED: Tribolium castaneum uncharacterized LOC664289 (LOC664289), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40420 BP_3 864.34 4.76 9041 642923740 XP_008193866.1 1948 7.7e-215 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X8 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O35547 1209 1.6e-130 Long-chain-fatty-acid--CoA ligase 4 OS=Rattus norvegicus GN=Acsl4 PE=1 SV=1 PF06624//PF00908//PF15138//PF09259//PF00501 Ribosome associated membrane protein RAMP4//dTDP-4-dehydrorhamnose 3,5-epimerase//Syncollin//Fungal immunomodulatory protein Fve//AMP-binding enzyme GO:0002682//GO:0006887//GO:0009117//GO:0019872//GO:0008152//GO:0030639 regulation of immune system process//exocytosis//nucleotide metabolic process//streptomycin biosynthetic process//metabolic process//polyketide biosynthetic process GO:0008830//GO:0030246//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//carbohydrate binding//catalytic activity GO:0005783//GO:0030667 endoplasmic reticulum//secretory granule membrane KOG1180 Acyl-CoA synthetase Cluster-8309.40421 BP_3 167.61 6.39 1557 642929019 XP_008195657.1 726 6.6e-74 PREDICTED: uncharacterized protein LOC662417 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.40423 BP_3 13.00 0.35 2095 270012045 EFA08493.1 1034 1.7e-109 hypothetical protein TcasGA2_TC006145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.40424 BP_3 194.68 2.73 3724 642928866 XP_008195596.1 3145 0.0e+00 PREDICTED: protein EFR3 homolog cmp44E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IGJ0 2001 9.3e-223 Protein EFR3 homolog cmp44E OS=Drosophila melanogaster GN=stmA PE=2 SV=3 PF07244//PF05000 Surface antigen variable number repeat//RNA polymerase Rpb1, domain 4 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0019867 nucleolus//outer membrane KOG1877 Putative transmembrane protein cmp44E Cluster-8309.40426 BP_3 562.00 24.55 1395 478257591 ENN77745.1 915 7.2e-96 hypothetical protein YQE_05815, partial [Dendroctonus ponderosae]>gi|546677145|gb|ERL88042.1| hypothetical protein D910_05431 [Dendroctonus ponderosae] -- -- -- -- -- K18666 ASCC1 activating signal cointegrator complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18666 Q9D8Z1 480 8.2e-47 Activating signal cointegrator 1 complex subunit 1 OS=Mus musculus GN=Ascc1 PE=2 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2814 Transcription coactivator complex, P50 component (LigT RNA ligase/phosphodiesterase family) Cluster-8309.40428 BP_3 80.97 1.45 2987 640802703 XP_008057688.1 799 4.4e-82 PREDICTED: zinc finger protein 658B-like [Tarsius syrichta] -- -- -- -- -- -- -- -- -- Q14590 778 4.9e-81 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF13465//PF00096//PF07776//PF16622//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.40430 BP_3 3717.41 167.57 1361 332372732 AEE61508.1 1136 1.7e-121 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 758 4.6e-79 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191//PF08294//PF00802 Annexin//TIM21//Pneumovirus attachment glycoprotein G GO:0030150 protein import into mitochondrial matrix GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding GO:0005744//GO:0055036 mitochondrial inner membrane presequence translocase complex//virion membrane KOG0819 Annexin Cluster-8309.40431 BP_3 181.29 7.31 1487 546681897 ERL91906.1 667 4.4e-67 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 321 2.4e-28 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40432 BP_3 123.79 0.61 10089 642914147 XP_008201565.1 9361 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1238 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.2e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.40433 BP_3 64.23 2.11 1762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.40434 BP_3 766.26 20.60 2085 642923280 XP_008193688.1 149 7.2e-07 PREDICTED: long-chain fatty acid transport protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00487//PF06703//PF03419 Fatty acid desaturase//Microsomal signal peptidase 25 kDa subunit (SPC25)//Sporulation factor SpoIIGA GO:0030436//GO:0006508//GO:0006465//GO:0006629 asexual sporulation//proteolysis//signal peptide processing//lipid metabolic process GO:0008233//GO:0004190 peptidase activity//aspartic-type endopeptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.40435 BP_3 1913.25 8.41 11262 642918088 XP_008193953.1 2255 2.4e-250 PREDICTED: uncharacterized protein LOC103313170 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17480 AATK, LMTK1 lemur tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17480 Q6ZMQ8 601 6.1e-60 Serine/threonine-protein kinase LMTK1 OS=Homo sapiens GN=AATK PE=1 SV=2 PF14991//PF07402//PF07714//PF00069 Protein melan-A//Human herpesvirus U26 protein//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0042470//GO:0016021 melanosome//integral component of membrane -- -- Cluster-8309.40436 BP_3 57.21 1.54 2081 478249899 ENN70406.1 717 9.8e-73 hypothetical protein YQE_12912, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VCH8 360 1.0e-32 Transmembrane protein 65 OS=Bos taurus GN=TMEM65 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4619 Uncharacterized conserved protein Cluster-8309.40437 BP_3 238.02 4.07 3112 642913255 XP_008201459.1 819 2.2e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 7.36372e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.8e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF00076//PF16367//PF01024 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Colicin pore forming domain GO:0050829//GO:0019835 defense response to Gram-negative bacterium//cytolysis GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding GO:0016021 integral component of membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40438 BP_3 220.26 3.94 2983 642913258 XP_008201460.1 819 2.1e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 175 7.0549e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.5e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF01024//PF16367//PF00076 Colicin pore forming domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40439 BP_3 934.20 11.63 4162 332374310 AEE62296.1 1023 6.4e-108 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 474 1.2e-45 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF01353 Green fluorescent protein GO:0008218 bioluminescence -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.40440 BP_3 570.01 3.85 7435 332376114 AEE63197.1 1491 6.2e-162 unknown [Dendroctonus ponderosae] 332376113 BT128237.1 195 1.34943e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 900 8.7e-95 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF00412//PF13180//PF05493//PF07994 PDZ domain (Also known as DHR or GLGF)//LIM domain//PDZ domain//ATP synthase subunit H//Myo-inositol-1-phosphate synthase GO:0008654//GO:0015992//GO:0019872//GO:0015991//GO:0006021 phospholipid biosynthetic process//proton transport//streptomycin biosynthetic process//ATP hydrolysis coupled proton transport//inositol biosynthetic process GO:0015078//GO:0008270//GO:0004512//GO:0005515 hydrogen ion transmembrane transporter activity//zinc ion binding//inositol-3-phosphate synthase activity//protein binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40441 BP_3 70.46 1.15 3239 332372624 AEE61454.1 1753 1.1e-192 unknown [Dendroctonus ponderosae] 645007963 XM_008205563.1 265 7.14403e-134 PREDICTED: Nasonia vitripennis SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (LOC100118240), transcript variant X4, mRNA K11648 SMARCB1, SNF5, INI1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11648 Q6DFM1 1331 4.0e-145 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xenopus tropicalis GN=smarcb1 PE=2 SV=1 PF04855//PF08039 SNF5 / SMARCB1 / INI1//Mitochondrial proteolipid GO:0006338 chromatin remodeling -- -- GO:0005739//GO:0000228 mitochondrion//nuclear chromosome KOG1649 SWI-SNF chromatin remodeling complex, Snf5 subunit Cluster-8309.40442 BP_3 12.61 0.61 1288 546675964 ERL87059.1 1145 1.4e-122 hypothetical protein D910_04460, partial [Dendroctonus ponderosae] 641676797 XM_008189320.1 35 2.00803e-06 PREDICTED: Acyrthosiphon pisum PDZ and LIM domain protein Zasp (LOC100162539), transcript variant X5, mRNA -- -- -- -- A1ZA47 655 3.8e-67 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40444 BP_3 90.63 2.24 2238 189234482 XP_970034.2 1070 1.2e-113 PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|270001732|gb|EEZ98179.1| hypothetical protein TcasGA2_TC000608 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q8UWA5 340 2.2e-30 Carbonic anhydrase 2 OS=Tribolodon hakonensis GN=ca2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40445 BP_3 997.47 5.04 9827 642925384 XP_008194526.1 13580 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [Tribolium castaneum] 815805023 XM_012367811.1 84 9.04437e-33 PREDICTED: Linepithema humile transcription-associated protein 1 (LOC105672707), mRNA K08874 TRRAP transformation/transcription domain-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08874 Q9Y4A5 8483 0.0e+00 Transformation/transcription domain-associated protein OS=Homo sapiens GN=TRRAP PE=1 SV=3 PF02259 FAT domain -- -- GO:0005515 protein binding -- -- KOG0889 Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily Cluster-8309.40447 BP_3 1172.71 49.61 1431 546681897 ERL91906.1 923 8.7e-97 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 459 2.3e-44 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40448 BP_3 2.00 0.54 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40449 BP_3 815.31 4.07 9948 642914147 XP_008201565.1 9307 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1202 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.1e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.40450 BP_3 488.63 0.96 24762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03493 Calcium-activated BK potassium channel alpha subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.40451 BP_3 43.45 0.78 2984 91087251 XP_975522.1 358 6.0e-31 PREDICTED: uncharacterized protein LOC664422 [Tribolium castaneum]>gi|270009553|gb|EFA06001.1| hypothetical protein TcasGA2_TC008827 [Tribolium castaneum] -- -- -- -- -- K04402 GADD45 growth arrest and DNA-damage-inducible protein http://www.genome.jp/dbget-bin/www_bget?ko:K04402 -- -- -- -- -- -- GO:0006950//GO:0051726 response to stress//regulation of cell cycle -- -- GO:0005634 nucleus -- -- Cluster-8309.40453 BP_3 735.03 8.32 4548 642937750 XP_008198931.1 1336 3.6e-144 PREDICTED: GRAM domain-containing protein 3-like isoform X3 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.55367e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q80TI0 272 3.5e-22 GRAM domain-containing protein 1B OS=Mus musculus GN=Gramd1b PE=2 SV=2 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.40454 BP_3 119.13 1.39 4430 642937748 XP_008198930.1 1378 4.7e-149 PREDICTED: GRAM domain-containing protein 3-like isoform X2 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.51304e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q3KR37 272 3.4e-22 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.40455 BP_3 35.43 0.45 4061 642937748 XP_008198930.1 1378 4.3e-149 PREDICTED: GRAM domain-containing protein 3-like isoform X2 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.38598e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q3KR37 272 3.1e-22 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.40457 BP_3 570.38 6.57 4475 91087897 XP_970459.1 859 7.2e-89 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270012016|gb|EFA08464.1| hypothetical protein TcasGA2_TC006113 [Tribolium castaneum] 642930872 XM_965366.2 96 8.75495e-40 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 9.7e-17 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF11808//PF05495//PF00412 Domain of unknown function (DUF3329)//CHY zinc finger//LIM domain GO:0016310 phosphorylation GO:0004673//GO:0008270 protein histidine kinase activity//zinc ion binding GO:0009365 protein histidine kinase complex -- -- Cluster-8309.40458 BP_3 43.39 1.36 1829 189236914 XP_969111.2 732 1.6e-74 PREDICTED: alpha-(1,6)-fucosyltransferase [Tribolium castaneum]>gi|270006336|gb|EFA02784.1| hypothetical protein TcasGA2_TC008521 [Tribolium castaneum] -- -- -- -- -- K00717 FUT8 glycoprotein 6-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00717 Q9VYV5 287 2.6e-24 Alpha-(1,6)-fucosyltransferase OS=Drosophila melanogaster GN=FucT6 PE=1 SV=1 PF03462//PF09807//PF03938 PCRF domain//Elongation complex protein 6//Outer membrane protein (OmpH-like) GO:0006415//GO:0006449 translational termination//regulation of translational termination GO:0051082//GO:0016149 unfolded protein binding//translation release factor activity, codon specific GO:0005840//GO:0018444//GO:0005737//GO:0033588 ribosome//translation release factor complex//cytoplasm//Elongator holoenzyme complex KOG3705 Glycoprotein 6-alpha-L-fucosyltransferase Cluster-8309.40459 BP_3 643.18 4.45 7265 189239910 XP_001811161.1 2656 4.9e-297 PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|642931213|ref|XP_008196486.1| PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|270012115|gb|EFA08563.1| hypothetical protein TcasGA2_TC006218 [Tribolium castaneum] 642931212 XM_008198264.1 80 1.11738e-30 PREDICTED: Tribolium castaneum uncharacterized LOC100142394 (LOC100142394), transcript variant X2, mRNA -- -- -- -- P91791 286 1.3e-23 Peptidyl-prolyl cis-trans isomerase OS=Hemicentrotus pulcherrimus PE=2 SV=1 PF00097//PF14634//PF01363//PF00643//PF13639//PF04277//PF00160 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//FYVE zinc finger//B-box zinc finger//Ring finger domain//Oxaloacetate decarboxylase, gamma chain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0006525//GO:0006560//GO:0006090//GO:0071436//GO:0006814//GO:0000413 protein folding//arginine metabolic process//proline metabolic process//pyruvate metabolic process//sodium ion export//sodium ion transport//protein peptidyl-prolyl isomerization GO:0005515//GO:0008948//GO:0003755//GO:0008270//GO:0046872//GO:0015081 protein binding//oxaloacetate decarboxylase activity//peptidyl-prolyl cis-trans isomerase activity//zinc ion binding//metal ion binding//sodium ion transmembrane transporter activity GO:0005622//GO:0016020 intracellular//membrane KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.40460 BP_3 1086.22 28.95 2100 91083817 XP_973463.1 1845 1.6e-203 PREDICTED: large neutral amino acids transporter small subunit 2 [Tribolium castaneum]>gi|270006773|gb|EFA03221.1| hypothetical protein TcasGA2_TC013142 [Tribolium castaneum] -- -- -- -- -- K13780 SLC7A5, LAT1 solute carrier family 7 (L-type amino acid transporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13780 Q01650 1148 4.3e-124 Large neutral amino acids transporter small subunit 1 OS=Homo sapiens GN=SLC7A5 PE=1 SV=2 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1287 Amino acid transporters Cluster-8309.40462 BP_3 352.84 7.75 2486 546684670 ERL94287.1 522 4.8e-50 hypothetical protein D910_11568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NJ15 132 3.3e-06 Proprotein convertase subtilisin/kexin type 5 OS=Branchiostoma californiense GN=PC6 PE=2 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.40463 BP_3 32.21 0.43 3865 332375078 AEE62680.1 1122 2.0e-119 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14457 MOGAT2, MGAT2 2-acylglycerol O-acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14457 Q3SYC2 664 1.0e-67 2-acylglycerol O-acyltransferase 2 OS=Homo sapiens GN=MOGAT2 PE=1 SV=2 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.40465 BP_3 134.41 2.41 2978 91090214 XP_967924.1 1528 1.3e-166 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 652 2.0e-66 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.40467 BP_3 1019.04 32.12 1821 91086561 XP_975997.1 1203 3.8e-129 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X1 [Tribolium castaneum]>gi|270009775|gb|EFA06223.1| hypothetical protein TcasGA2_TC009072 [Tribolium castaneum] 766927493 XM_011497449.1 59 1.30369e-19 PREDICTED: Ceratosolen solmsi marchali phosphoenolpyruvate carboxykinase [GTP]-like (LOC105360529), mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 995 2.0e-106 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006099//GO:0006094 tricarboxylic acid cycle//gluconeogenesis GO:0005525//GO:0004613//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase (GTP) activity//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.40470 BP_3 679.51 14.45 2559 642914669 XP_008190307.1 2276 2.0e-253 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6P2X9 431 7.2e-41 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF01306//PF07690 LacY proton/sugar symporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.40471 BP_3 289.97 3.44 4359 642922337 XP_008193118.1 1681 3.4e-184 PREDICTED: four and a half LIM domains protein 2 isoform X4 [Tribolium castaneum] 642922336 XM_008194896.1 488 0 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X4, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 1001 9.9e-107 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF00412//PF07562 LIM domain//Nine Cysteines Domain of family 3 GPCR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0008270 G-protein coupled receptor activity//zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.40472 BP_3 126.74 2.42 2812 270007215 EFA03663.1 306 6.0e-25 hypothetical protein TcasGA2_TC013758 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40477 BP_3 1068.02 25.28 2328 642936150 XP_975125.2 939 2.0e-98 PREDICTED: zinc transporter ZIP13 homolog [Tribolium castaneum] -- -- -- -- -- K14719 SLC39A13, ZIP13 solute carrier family 39 (zinc transporter), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K14719 Q9VAF0 594 8.2e-60 Zinc transporter ZIP13 homolog OS=Drosophila melanogaster GN=Zip99C PE=2 SV=1 PF03352//PF02535 Methyladenine glycosylase//ZIP Zinc transporter GO:0030001//GO:0055085//GO:0006284 metal ion transport//transmembrane transport//base-excision repair GO:0008725//GO:0046873 DNA-3-methyladenine glycosylase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.40478 BP_3 397.08 2.79 7155 91090606 XP_973086.1 645 7.5e-64 PREDICTED: peroxisomal membrane protein PEX14 [Tribolium castaneum] -- -- -- -- -- K13343 PEX14 peroxin-14 http://www.genome.jp/dbget-bin/www_bget?ko:K13343 Q642G4 224 2.0e-16 Peroxisomal membrane protein PEX14 OS=Rattus norvegicus GN=Pex14 PE=1 SV=1 PF05008 Vesicle transport v-SNARE protein N-terminus GO:0006886 intracellular protein transport -- -- GO:0016020 membrane KOG2629 Peroxisomal membrane anchor protein (peroxin) Cluster-8309.40479 BP_3 1363.62 34.33 2206 478263357 ENN81733.1 230 3.1e-16 hypothetical protein YQE_01872, partial [Dendroctonus ponderosae]>gi|546681305|gb|ERL91419.1| hypothetical protein D910_08751 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0032222//GO:0030431//GO:1903818 regulation of synaptic transmission, cholinergic//sleep//positive regulation of voltage-gated potassium channel activity GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.4048 BP_3 19.86 1.39 978 642920385 XP_008192323.1 969 2.8e-102 PREDICTED: UDP-glucuronosyltransferase 2C1 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q8BWQ1 493 1.8e-48 UDP-glucuronosyltransferase 2A3 OS=Mus musculus GN=Ugt2a3 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.40480 BP_3 448.30 8.85 2732 642914891 XP_008190433.1 1675 1.1e-183 PREDICTED: CTL-like protein 2 isoform X2 [Tribolium castaneum] 620966641 XM_007658441.1 44 4.28874e-11 PREDICTED: Ornithorhynchus anatinus choline transporter-like protein 2 (LOC100086451), mRNA K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 1269 5.2e-138 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.40481 BP_3 302.63 3.01 5134 546675851 ERL86956.1 2495 1.6e-278 hypothetical protein D910_04359 [Dendroctonus ponderosae] 676491074 XM_009067230.1 96 1.00547e-39 Lottia gigantea hypothetical protein mRNA K12179 COPS6, CSN6 COP9 signalosome complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12179 Q9VCY3 1146 1.8e-123 COP9 signalosome complex subunit 6 OS=Drosophila melanogaster GN=CSN6 PE=1 SV=1 PF05028//PF01398//PF01920 Poly (ADP-ribose) glycohydrolase (PARG)//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Prefoldin subunit GO:0005975//GO:0006457 carbohydrate metabolic process//protein folding GO:0004649//GO:0005515//GO:0051082 poly(ADP-ribose) glycohydrolase activity//protein binding//unfolded protein binding GO:0016272 prefoldin complex KOG3050 COP9 signalosome, subunit CSN6 Cluster-8309.40483 BP_3 52.39 0.62 4390 282158073 NP_001164080.1 2013 1.1e-222 saxophone precursor [Tribolium castaneum] -- -- -- -- -- K04675 ACVR1, ALK2 activin receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04675 P80201 1273 2.9e-138 Activin receptor type-1 OS=Rattus norvegicus GN=Acvr1 PE=2 SV=1 PF08515//PF00087//PF07714//PF01064//PF00069 Transforming growth factor beta type I GS-motif//Snake toxin//Protein tyrosine kinase//Activin types I and II receptor domain//Protein kinase domain GO:0009405//GO:0007178//GO:0016310//GO:0006468//GO:0009069 pathogenesis//transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.40484 BP_3 3.00 0.55 553 642925968 XP_008194714.1 206 4.6e-14 PREDICTED: uncharacterized protein LOC655532 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03444 Winged helix-turn-helix transcription repressor, HrcA DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.40485 BP_3 177.97 2.02 4538 642919813 XP_008192079.1 4520 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X4 [Tribolium castaneum] 642919812 XM_008193857.1 725 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X4, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1844 1.8e-204 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF05445//PF00069//PF06293//PF07714 Poxvirus serine/threonine protein kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.40491 BP_3 3354.50 19.02 8791 642933622 XP_008197499.1 5260 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [Tribolium castaneum]>gi|270011314|gb|EFA07762.1| hypothetical protein TcasGA2_TC005316 [Tribolium castaneum] 641702319 XM_008141598.1 150 1.65426e-69 PREDICTED: Eptesicus fuscus ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), transcript variant X3, mRNA K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 3619 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 PF13414//PF00443//PF02430//PF00917//PF15499//PF00240 TPR repeat//Ubiquitin carboxyl-terminal hydrolase//Apical membrane antigen 1//MATH domain//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Ubiquitin family GO:0009405//GO:0016579//GO:0006511 pathogenesis//protein deubiquitination//ubiquitin-dependent protein catabolic process GO:0005515//GO:0070140//GO:0032183//GO:0036459//GO:0004221 protein binding//SUMO-specific isopeptidase activity//SUMO binding//ubiquitinyl hydrolase activity//obsolete ubiquitin thiolesterase activity GO:0016020 membrane KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.40492 BP_3 147.68 3.54 2300 478253101 ENN73474.1 189 1.8e-11 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40493 BP_3 64.18 0.40 8122 478251011 ENN71492.1 1218 3.1e-130 hypothetical protein YQE_11788, partial [Dendroctonus ponderosae] -- -- -- -- -- K09592 EGLN, HPH hypoxia-inducible factor prolyl hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K09592 Q91YE3 670 4.4e-68 Egl nine homolog 1 OS=Mus musculus GN=Egln1 PE=2 SV=2 PF13640//PF01254 2OG-Fe(II) oxygenase superfamily//Nuclear transition protein 2 GO:0055114//GO:0007283 oxidation-reduction process//spermatogenesis GO:0003677//GO:0016491 DNA binding//oxidoreductase activity GO:0005634//GO:0000786 nucleus//nucleosome KOG3710 EGL-Nine (EGLN) protein Cluster-8309.40494 BP_3 378.00 12.74 1722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40495 BP_3 471.40 8.34 3015 189238048 XP_001811309.1 1728 8.3e-190 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 2.1e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF01370//PF01073//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0008210 C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//estrogen metabolic process GO:0080019//GO:0003854//GO:0050662//GO:0003824//GO:0016616 fatty-acyl-CoA reductase (alcohol-forming) activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1221 Acyl-CoA reductase Cluster-8309.40496 BP_3 124.36 1.33 4812 189237690 XP_969477.2 3405 0.0e+00 PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|642924144|ref|XP_008194025.1| PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|270008133|gb|EFA04581.1| signal-transducer and activator of transcription protein [Tribolium castaneum] 642924143 XM_008195803.1 434 0 PREDICTED: Tribolium castaneum signal-transducer and activator of transcription protein (LOC657965), transcript variant X2, mRNA K11224 STAT5B signal transducer and activator of transcription 5B http://www.genome.jp/dbget-bin/www_bget?ko:K11224 Q9TUZ0 1741 1.7e-192 Signal transducer and activator of transcription 5B OS=Sus scrofa GN=STAT5B PE=2 SV=1 PF02864//PF01017//PF02865 STAT protein, DNA binding domain//STAT protein, all-alpha domain//STAT protein, protein interaction domain GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003700//GO:0004871//GO:0005509 transcription factor activity, sequence-specific DNA binding//signal transducer activity//calcium ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.40497 BP_3 976.59 10.04 4979 642924146 XP_008194026.1 3330 0.0e+00 PREDICTED: signal transducer and activator of transcription 5B isoform X2 [Tribolium castaneum] 642924145 XM_008195804.1 442 0 PREDICTED: Tribolium castaneum signal-transducer and activator of transcription protein (LOC657965), transcript variant X3, mRNA K11224 STAT5B signal transducer and activator of transcription 5B http://www.genome.jp/dbget-bin/www_bget?ko:K11224 Q9TUZ0 1741 1.8e-192 Signal transducer and activator of transcription 5B OS=Sus scrofa GN=STAT5B PE=2 SV=1 PF02864//PF01017//PF02865 STAT protein, DNA binding domain//STAT protein, all-alpha domain//STAT protein, protein interaction domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003700//GO:0004871 transcription factor activity, sequence-specific DNA binding//signal transducer activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.405 BP_3 28.08 2.42 850 642939055 XP_008200202.1 243 3.7e-18 PREDICTED: uncharacterized protein LOC103314863 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40500 BP_3 54.66 1.15 2584 642917177 XP_008191151.1 756 3.6e-77 PREDICTED: pangolin isoform X3 [Tribolium castaneum] 642917176 XM_008192929.1 411 0 PREDICTED: Tribolium castaneum pangolin (Pan), transcript variant X3, mRNA K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 P91943 333 1.7e-29 Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3248 Transcription factor TCF-4 Cluster-8309.40501 BP_3 266.00 7.69 1958 642917173 XP_008191149.1 1345 1.4e-145 PREDICTED: pangolin isoform X1 [Tribolium castaneum] 642917176 XM_008192929.1 645 0 PREDICTED: Tribolium castaneum pangolin (Pan), transcript variant X3, mRNA K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 P91943 664 5.3e-68 Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3248 Transcription factor TCF-4 Cluster-8309.40502 BP_3 71.26 0.32 10963 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.40503 BP_3 151.42 7.45 1272 270003498 EEZ99945.1 1414 9.0e-154 hypothetical protein TcasGA2_TC002741 [Tribolium castaneum] -- -- -- -- -- K12316 GAA lysosomal alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12316 P70699 916 2.1e-97 Lysosomal alpha-glucosidase OS=Mus musculus GN=Gaa PE=1 SV=2 PF01055//PF03498 Glycosyl hydrolases family 31//Cytolethal distending toxin A/C domain GO:0005975//GO:0009405 carbohydrate metabolic process//pathogenesis GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.40504 BP_3 1106.71 15.32 3773 91092740 XP_973214.1 1339 1.3e-144 PREDICTED: alpha/beta hydrolase domain-containing protein 17B [Tribolium castaneum]>gi|270014884|gb|EFA11332.1| hypothetical protein TcasGA2_TC010871 [Tribolium castaneum] 642911451 XM_968121.3 343 3.63872e-177 PREDICTED: Tribolium castaneum alpha/beta hydrolase domain-containing protein 17B (LOC661993), mRNA -- -- -- -- Q7ZVZ7 1114 6.7e-120 Alpha/beta hydrolase domain-containing protein 17C OS=Danio rerio GN=abhd17c PE=2 SV=1 PF02230//PF00326//PF16929//PF01738 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Accessory Sec system GspB-transporter//Dienelactone hydrolase family GO:0015031//GO:0006508 protein transport//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.40506 BP_3 89.97 1.69 2865 642938354 XP_008198798.1 765 3.7e-78 PREDICTED: peptidyl-prolyl cis-trans isomerase G [Tribolium castaneum] 645259408 XM_008237125.1 62 4.43708e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 O55035 612 8.3e-62 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF06213//PF02862//PF02724//PF03522//PF02535//PF06459//PF00160//PF08496//PF09507//PF05132//PF01080//PF03839 Cobalamin biosynthesis protein CobT//DDHD domain//CDC45-like protein//Solute carrier family 12//ZIP Zinc transporter//Ryanodine Receptor TM 4-6//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Peptidase family S49 N-terminal//DNA polymerase subunit Cdc27//RNA polymerase III RPC4//Presenilin//Translocation protein Sec62 GO:0006144//GO:0006351//GO:0030001//GO:0006457//GO:0006811//GO:0006206//GO:0006810//GO:0006816//GO:0015031//GO:0006874//GO:0006383//GO:0000413//GO:0006270//GO:0055085//GO:0009236//GO:0006260 purine nucleobase metabolic process//transcription, DNA-templated//metal ion transport//protein folding//ion transport//pyrimidine nucleobase metabolic process//transport//calcium ion transport//protein transport//cellular calcium ion homeostasis//transcription from RNA polymerase III promoter//protein peptidyl-prolyl isomerization//DNA replication initiation//transmembrane transport//cobalamin biosynthetic process//DNA replication GO:0005219//GO:0003677//GO:0003899//GO:0004252//GO:0008565//GO:0005215//GO:0004190//GO:0046872//GO:0046873//GO:0003755 ryanodine-sensitive calcium-release channel activity//DNA binding//DNA-directed RNA polymerase activity//serine-type endopeptidase activity//protein transporter activity//transporter activity//aspartic-type endopeptidase activity//metal ion binding//metal ion transmembrane transporter activity//peptidyl-prolyl cis-trans isomerase activity GO:0005634//GO:0005886//GO:0016020//GO:0016021//GO:0005622//GO:0005730//GO:0005666 nucleus//plasma membrane//membrane//integral component of membrane//intracellular//nucleolus//DNA-directed RNA polymerase III complex KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.40507 BP_3 90.29 1.35 3518 642931467 XP_966826.3 1593 4.4e-174 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q05B81 249 1.3e-19 Proton-coupled folate transporter OS=Bos taurus GN=SLC46A1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.40508 BP_3 934.25 11.31 4274 91093306 XP_967617.1 1066 6.8e-113 PREDICTED: putative protein FAM10A4 [Tribolium castaneum]>gi|270014189|gb|EFA10637.1| hypothetical protein TcasGA2_TC016274 [Tribolium castaneum] -- -- -- -- -- K09560 ST13 suppressor of tumorigenicity protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09560 Q5ZLF0 702 4.5e-72 Hsc70-interacting protein OS=Gallus gallus GN=ST13 PE=2 SV=1 PF00522//PF01835//PF13414//PF13176//PF04194//PF00515//PF13374//PF13371//PF13174//PF13181 VPR/VPX protein//MG2 domain//TPR repeat//Tetratricopeptide repeat//Programmed cell death protein 2, C-terminal putative domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019058 viral life cycle GO:0004866//GO:0005515 endopeptidase inhibitor activity//protein binding GO:0005737//GO:0042025 cytoplasm//host cell nucleus KOG1308 Hsp70-interacting protein Hip/Transient component of progesterone receptor complexes and an Hsp70-binding protein Cluster-8309.40509 BP_3 29.00 1.06 1615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01003 Flavivirus capsid protein C -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.40510 BP_3 798.81 10.42 3987 642923393 XP_008193730.1 1613 2.4e-176 PREDICTED: facilitated trehalose transporter Tret1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 457 1.1e-43 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF11789//PF07690//PF12678//PF14634//PF00097//PF13639//PF16685//PF12861//PF01589 Sugar (and other) transporter//Zinc-finger of the MIZ type in Nse subunit//Major Facilitator Superfamily//RING-H2 zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//zinc RING finger of MSL2//Anaphase-promoting complex subunit 11 RING-H2 finger//Alphavirus E1 glycoprotein GO:0016567//GO:0055085 protein ubiquitination//transmembrane transport GO:0046872//GO:0004252//GO:0008270//GO:0061630//GO:0004842//GO:0005515//GO:0022857 metal ion binding//serine-type endopeptidase activity//zinc ion binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//protein binding//transmembrane transporter activity GO:0055036//GO:0005680//GO:0019028//GO:0016021 virion membrane//anaphase-promoting complex//viral capsid//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.40512 BP_3 1393.07 8.60 8098 189241962 XP_968788.2 787 2.9e-80 PREDICTED: remodeling and spacing factor 1-like [Tribolium castaneum] -- -- -- -- -- K11657 RSF1 remodeling and spacing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11657 Q96T23 382 1.1e-34 Remodeling and spacing factor 1 OS=Homo sapiens GN=RSF1 PE=1 SV=2 PF01428//PF10404//PF00628 AN1-like Zinc finger//Rad4 beta-hairpin domain 2//PHD-finger -- -- GO:0003677//GO:0008270//GO:0005515 DNA binding//zinc ion binding//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.40513 BP_3 183.76 5.51 1899 478252939 ENN73323.1 2382 7.6e-266 hypothetical protein YQE_10085, partial [Dendroctonus ponderosae] 808134796 XM_003399528.2 257 1.16451e-129 PREDICTED: Bombus terrestris uncharacterized LOC100647816 (LOC100647816), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40515 BP_3 1340.00 26.39 2739 642912091 XP_008200799.1 786 1.3e-80 PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912093|ref|XP_008200800.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912095|ref|XP_008200802.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum] 642912098 XM_008202582.1 273 2.15306e-138 PREDICTED: Tribolium castaneum ecdysone-induced protein 74EF (LOC655028), transcript variant X5, mRNA K09428 ELF1_2_4 E74-like factor 1/2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K09428 P11536 617 2.1e-62 Ecdysone-induced protein 74EF isoform B OS=Drosophila melanogaster GN=Eip74EF PE=2 SV=2 PF00178 Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3804 Transcription factor NERF and related proteins, contain ETS domain Cluster-8309.40517 BP_3 53.53 0.58 4741 642934737 XP_008197792.1 1348 1.5e-145 PREDICTED: uncharacterized protein LOC103314212 [Tribolium castaneum] 768447197 XM_011567278.1 52 2.67297e-15 PREDICTED: Plutella xylostella vegetative cell wall protein gp1 (LOC105395329), mRNA -- -- -- -- -- -- -- -- PF00057//PF00599 Low-density lipoprotein receptor domain class A//Influenza Matrix protein (M2) GO:0015992 proton transport GO:0005515//GO:0015078 protein binding//hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036 host cell membrane//virion membrane -- -- Cluster-8309.40518 BP_3 11.11 0.43 1530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40521 BP_3 24.39 1.65 1006 642922198 XP_008193058.1 407 4.2e-37 PREDICTED: patronin isoform X5 [Tribolium castaneum] -- -- -- -- -- K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 200 1.7e-14 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40523 BP_3 147.54 1.39 5425 642926303 XP_008194869.1 1059 5.6e-112 PREDICTED: GDNF-inducible zinc finger protein 1-like [Tribolium castaneum]>gi|270008503|gb|EFA04951.1| hypothetical protein TcasGA2_TC015019 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJU3 323 5.1e-28 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13912//PF16622//PF00096//PF13465 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40524 BP_3 735.14 1.93 18629 612342210 AHW99830.1 17783 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1032 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 14917 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00520//PF00487//PF06423//PF06459//PF00622//PF01365//PF13499//PF13833//PF02815 Ion transport protein//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//SPRY domain//RIH domain//EF-hand domain pair//EF-hand domain pair//MIR domain GO:0006629//GO:0006811//GO:0006506//GO:0070588//GO:0055085//GO:0006816//GO:0006874 lipid metabolic process//ion transport//GPI anchor biosynthetic process//calcium ion transmembrane transport//transmembrane transport//calcium ion transport//cellular calcium ion homeostasis GO:0005515//GO:0005219//GO:0016746//GO:0005262//GO:0005509//GO:0005216 protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium channel activity//calcium ion binding//ion channel activity GO:0005789//GO:0016020//GO:0016021//GO:0005622 endoplasmic reticulum membrane//membrane//integral component of membrane//intracellular KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.40527 BP_3 1071.46 6.23 8583 270012359 EFA08807.1 1919 1.7e-211 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.3e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF00098//PF04564//PF14634//PF02817//PF00097//PF01588//PF08783//PF00198//PF13639 Zinc knuckle//U-box domain//zinc-RING finger domain//e3 binding domain//Zinc finger, C3HC4 type (RING finger)//Putative tRNA binding domain//DWNN domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Ring finger domain GO:0008152//GO:0016567 metabolic process//protein ubiquitination GO:0005515//GO:0000049//GO:0004842//GO:0016746//GO:0003676//GO:0008270//GO:0046872 protein binding//tRNA binding//ubiquitin-protein transferase activity//transferase activity, transferring acyl groups//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.40529 BP_3 381.78 2.54 7540 642939432 XP_008200388.1 4207 0.0e+00 PREDICTED: pumilio homolog 2 isoform X1 [Tribolium castaneum] 642939441 XM_008202171.1 724 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X6, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806//PF02422 CPL (NUC119) domain//Pumilio-family RNA binding repeat//Keratin -- -- GO:0003723//GO:0005200 RNA binding//structural constituent of cytoskeleton GO:0005882//GO:0005856 intermediate filament//cytoskeleton KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.40530 BP_3 60.10 0.90 3520 329350997 AEB91339.1 1370 3.2e-148 salicyl alcohol oxidase paralog 1 [Chrysomela lapponica] -- -- -- -- -- K00115 E1.1.5.9 glucose dehydrogenase (acceptor) http://www.genome.jp/dbget-bin/www_bget?ko:K00115 P18173 637 1.3e-64 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF07992//PF05834//PF00732//PF01266//PF05199//PF02254 Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0055114//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//potassium ion transport GO:0016614//GO:0016705//GO:0050660//GO:0016491 oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.40531 BP_3 209.19 3.66 3046 642916135 XP_008190901.1 765 3.9e-78 PREDICTED: PQ-loop repeat-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N755 308 1.6e-26 PQ-loop repeat-containing protein 3 OS=Homo sapiens GN=PQLC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.40532 BP_3 1612.41 36.60 2415 270012526 EFA08974.1 251 1.2e-18 hypothetical protein TcasGA2_TC006681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40533 BP_3 778.19 8.05 4951 688589261 XP_009290233.1 283 4.9e-22 PREDICTED: zinc finger and SCAN domain containing 2-like isoform X1 [Danio rerio] 817210508 XM_012425923.1 169 2.54692e-80 PREDICTED: Orussus abietinus uncharacterized LOC105700249 (LOC105700249), mRNA K09203 EGR1 early growth response protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09203 Q9UII5 263 4.2e-21 Zinc finger protein 107 OS=Homo sapiens GN=ZNF107 PE=2 SV=1 PF13465//PF00076//PF16367//PF13912//PF02892//PF00096//PF05495//PF02207//PF05478 Zinc-finger double domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//CHY zinc finger//Putative zinc finger in N-recognin (UBR box)//Prominin -- -- GO:0046872//GO:0003676//GO:0003677//GO:0008270 metal ion binding//nucleic acid binding//DNA binding//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.40534 BP_3 416.72 4.09 5203 270007741 EFA04189.1 2015 7.5e-223 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 672078086 XM_006252000.2 43 2.95627e-10 PREDICTED: Rattus norvegicus ring finger protein 31 (Rnf31), transcript variant X1, mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q924T7 897 1.3e-94 E3 ubiquitin-protein ligase RNF31 OS=Mus musculus GN=Rnf31 PE=1 SV=2 PF05121//PF02845 Gas vesicle protein K//CUE domain GO:0031412 gas vesicle organization GO:0005515 protein binding -- -- KOG1812 Predicted E3 ubiquitin ligase Cluster-8309.40536 BP_3 2038.09 25.82 4097 91077414 XP_975386.1 1918 1.0e-211 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 5.3e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF12634//PF00516//PF06723//PF02782//PF13414//PF15281 Inheritance of peroxisomes protein 1//Envelope glycoprotein GP120//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//TPR repeat//Consortin C-terminus GO:0042998//GO:0006457//GO:0005975//GO:0045033//GO:0000902 positive regulation of Golgi to plasma membrane protein transport//protein folding//carbohydrate metabolic process//peroxisome inheritance//cell morphogenesis GO:0005515//GO:0071253//GO:0005524//GO:0016773//GO:0051082 protein binding//connexin binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//unfolded protein binding GO:0005802//GO:0019031//GO:0005780 trans-Golgi network//viral envelope//extrinsic component of intraperoxisomal membrane KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.40537 BP_3 464.93 4.53 5240 357619286 EHJ71921.1 431 3.6e-39 hypothetical protein KGM_05158 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.40538 BP_3 93.82 9.00 794 91082799 XP_967823.1 410 1.5e-37 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase hpo-8 [Tribolium castaneum]>gi|270007103|gb|EFA03551.1| hypothetical protein TcasGA2_TC013556 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q9D3B1 300 3.5e-26 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Mus musculus GN=Hacd2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40539 BP_3 171.91 5.71 1742 91082799 XP_967823.1 427 3.5e-39 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase hpo-8 [Tribolium castaneum]>gi|270007103|gb|EFA03551.1| hypothetical protein TcasGA2_TC013556 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 O17040 273 1.0e-22 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 OS=Caenorhabditis elegans GN=hpo-8 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40540 BP_3 76.60 1.10 3655 91082799 XP_967823.1 427 7.3e-39 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase hpo-8 [Tribolium castaneum]>gi|270007103|gb|EFA03551.1| hypothetical protein TcasGA2_TC013556 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 O17040 273 2.2e-22 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 OS=Caenorhabditis elegans GN=hpo-8 PE=3 SV=2 PF09768 Peptidase M76 family -- -- GO:0004222 metalloendopeptidase activity -- -- KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40541 BP_3 36.78 0.78 2562 91082797 XP_967743.1 383 6.5e-34 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q9D3B1 261 3.7e-21 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Mus musculus GN=Hacd2 PE=2 SV=1 PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40546 BP_3 184.00 11.11 1090 478255733 ENN75942.1 519 4.7e-50 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 222 5.3e-17 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.40547 BP_3 444.10 5.57 4136 642914748 XP_008190336.1 5332 0.0e+00 PREDICTED: potassium channel subfamily T member 2 [Tribolium castaneum] 642914747 XM_008192114.1 1140 0 PREDICTED: Tribolium castaneum potassium channel subfamily T member 2 (LOC655919), mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q8QFV0 1603 1.5e-176 Potassium channel subfamily T member 1 OS=Gallus gallus GN=KCNT1 PE=2 SV=1 PF01022//PF03493//PF00520 Bacterial regulatory protein, arsR family//Calcium-activated BK potassium channel alpha subunit//Ion transport protein GO:0006355//GO:0006811//GO:0055085//GO:0006813 regulation of transcription, DNA-templated//ion transport//transmembrane transport//potassium ion transport GO:0005216//GO:0003700//GO:0015269 ion channel activity//transcription factor activity, sequence-specific DNA binding//calcium-activated potassium channel activity GO:0016020//GO:0005667 membrane//transcription factor complex KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.40549 BP_3 79.75 0.48 8365 157106769 XP_001649474.1 419 1.4e-37 AAEL014742-PA, partial [Aedes aegypti]>gi|108868779|gb|EAT33004.1| AAEL014742-PA, partial [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q28F51 957 2.4e-101 TAR DNA-binding protein 43 OS=Xenopus tropicalis GN=tardbp PE=2 SV=1 PF16367//PF00076//PF13465//PF00023//PF16622//PF02892//PF13912//PF15750//PF00096//PF07776//PF13606 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc-finger double domain//Ankyrin repeat//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//Ubiquitin-binding zinc-finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Ankyrin repeat -- -- GO:0043130//GO:0008270//GO:0003677//GO:0003676//GO:0046872//GO:0005515 ubiquitin binding//zinc ion binding//DNA binding//nucleic acid binding//metal ion binding//protein binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.40550 BP_3 4482.11 86.23 2797 91087957 XP_972849.1 2969 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit B [Tribolium castaneum]>gi|270011918|gb|EFA08366.1| hypothetical protein TcasGA2_TC006009 [Tribolium castaneum] 759033163 XM_011349720.1 192 2.34385e-93 PREDICTED: Cerapachys biroi eukaryotic translation initiation factor 3 subunit B (LOC105285460), mRNA K03253 EIF3B translation initiation factor 3 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K03253 Q1HDZ5 2322 4.2e-260 Eukaryotic translation initiation factor 3 subunit B OS=Bombyx mori GN=eIF3-S9 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0000166//GO:0003676//GO:0003743 nucleotide binding//nucleic acid binding//translation initiation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm KOG2314 Translation initiation factor 3, subunit b (eIF-3b) Cluster-8309.40553 BP_3 2033.04 28.63 3714 478251310 ENN71778.1 2248 5.2e-250 hypothetical protein YQE_11513, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68FA7 147 8.9e-08 E3 ubiquitin-protein ligase MARCH3 OS=Xenopus tropicalis GN=march3 PE=2 SV=1 PF03186//PF00737//PF12906//PF04434 CobD/Cbib protein//Photosystem II 10 kDa phosphoprotein//RING-variant domain//SWIM zinc finger GO:0009236//GO:0015979//GO:0050821 cobalamin biosynthetic process//photosynthesis//protein stabilization GO:0008270//GO:0042301//GO:0048472 zinc ion binding//phosphate ion binding//threonine-phosphate decarboxylase activity GO:0009523//GO:0016020//GO:0016021 photosystem II//membrane//integral component of membrane KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.40554 BP_3 182.48 2.35 4030 478251310 ENN71778.1 1760 2.2e-193 hypothetical protein YQE_11513, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68FA7 147 9.7e-08 E3 ubiquitin-protein ligase MARCH3 OS=Xenopus tropicalis GN=march3 PE=2 SV=1 PF00737//PF13639//PF12906 Photosystem II 10 kDa phosphoprotein//Ring finger domain//RING-variant domain GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0008270//GO:0042301//GO:0005515 zinc ion binding//phosphate ion binding//protein binding GO:0016020//GO:0009523 membrane//photosystem II KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.40555 BP_3 1267.96 29.06 2395 91093675 XP_969585.1 1262 7.2e-136 PREDICTED: traB domain-containing protein [Tribolium castaneum]>gi|270008075|gb|EFA04523.1| hypothetical protein TcasGA2_TC016318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99JY4 634 1.9e-64 TraB domain-containing protein OS=Mus musculus GN=Trabd PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2860 Uncharacterized conserved protein, contains TraB domain Cluster-8309.40556 BP_3 151.91 1.65 4718 688589261 XP_009290233.1 275 4.0e-21 PREDICTED: zinc finger and SCAN domain containing 2-like isoform X1 [Danio rerio] 817210508 XM_012425923.1 150 8.85045e-70 PREDICTED: Orussus abietinus uncharacterized LOC105700249 (LOC105700249), mRNA K09203 EGR1 early growth response protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09203 Q99676 246 3.8e-19 Zinc finger protein 184 OS=Homo sapiens GN=ZNF184 PE=1 SV=4 PF05495//PF13465//PF00096//PF13912//PF02892//PF03868//PF02207 CHY zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Ribosomal protein L6, N-terminal domain//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003677//GO:0046872//GO:0008270//GO:0003735 DNA binding//metal ion binding//zinc ion binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.40557 BP_3 820.79 4.78 8566 642933622 XP_008197499.1 5274 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [Tribolium castaneum]>gi|270011314|gb|EFA07762.1| hypothetical protein TcasGA2_TC005316 [Tribolium castaneum] 641702319 XM_008141598.1 150 1.61174e-69 PREDICTED: Eptesicus fuscus ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), transcript variant X3, mRNA K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 3625 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 PF00443//PF15499//PF02430//PF00917//PF00240 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Apical membrane antigen 1//MATH domain//Ubiquitin family GO:0009405//GO:0006511//GO:0016579 pathogenesis//ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0036459//GO:0070140//GO:0032183//GO:0005515//GO:0004221 ubiquitinyl hydrolase activity//SUMO-specific isopeptidase activity//SUMO binding//protein binding//obsolete ubiquitin thiolesterase activity GO:0016020 membrane KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.40558 BP_3 11.00 2.43 510 642940190 XP_008200552.1 324 8.9e-28 PREDICTED: uncharacterized protein LOC103314959 isoform X2 [Tribolium castaneum]>gi|642940192|ref|XP_008200553.1| PREDICTED: uncharacterized protein LOC103314959 isoform X2 [Tribolium castaneum]>gi|270017054|gb|EFA13500.1| hypothetical protein TcasGA2_TC004259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF05491 THAP domain//Holliday junction DNA helicase ruvB C-terminus GO:0006281//GO:0006310 DNA repair//DNA recombination GO:0009378//GO:0003677//GO:0003676 four-way junction helicase activity//DNA binding//nucleic acid binding GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex -- -- Cluster-8309.40559 BP_3 872.61 11.37 3991 146411532 ABQ39970.1 2297 1.2e-255 heat shock protein 70 [Anatolica polita borealis] 645000994 XM_001599723.3 308 1.10145e-157 PREDICTED: Nasonia vitripennis heat shock protein 68-like (LOC100114907), mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P41825 2118 2.7e-236 Heat shock protein 70 A1 OS=Anopheles albimanus GN=HSP70A1 PE=3 SV=1 PF06723//PF02782//PF13855//PF01968//PF00560 MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//Leucine rich repeat//Hydantoinase/oxoprolinase//Leucine Rich Repeat GO:0000902//GO:0005975 cell morphogenesis//carbohydrate metabolic process GO:0016773//GO:0016787//GO:0005515 phosphotransferase activity, alcohol group as acceptor//hydrolase activity//protein binding -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.40560 BP_3 735.03 2.77 13082 189235004 XP_970036.2 3148 0.0e+00 PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [Tribolium castaneum]>gi|270003924|gb|EFA00372.1| hypothetical protein TcasGA2_TC003215 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 Q6IR34 1569 4.1e-172 G-protein-signaling modulator 1 OS=Mus musculus GN=Gpsm1 PE=1 SV=3 PF05194//PF13181//PF07714//PF10579//PF00069//PF13176//PF13414//PF02104//PF13374//PF04692//PF00515//PF00620//PF06293//PF02188 UreE urease accessory protein, C-terminal domain//Tetratricopeptide repeat//Protein tyrosine kinase//Rapsyn N-terminal myristoylation and linker region//Protein kinase domain//Tetratricopeptide repeat//TPR repeat//SURF1 family//Tetratricopeptide repeat//Platelet-derived growth factor, N terminal region//Tetratricopeptide repeat//RhoGAP domain//Lipopolysaccharide kinase (Kdo/WaaP) family//GoLoco motif GO:0040007//GO:0008283//GO:0019627//GO:0007165//GO:0006461//GO:0006468//GO:0007268 growth//cell proliferation//urea metabolic process//signal transduction//protein complex assembly//protein phosphorylation//synaptic transmission GO:0030695//GO:0016773//GO:0004672//GO:0043495//GO:0008083//GO:0033130//GO:0005515//GO:0016151//GO:0005524 GTPase regulator activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein anchor//growth factor activity//acetylcholine receptor binding//protein binding//nickel cation binding//ATP binding GO:0016020 membrane KOG1563 Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase Cluster-8309.40561 BP_3 3028.67 11.46 13026 189235004 XP_970036.2 3148 0.0e+00 PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [Tribolium castaneum]>gi|270003924|gb|EFA00372.1| hypothetical protein TcasGA2_TC003215 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 Q6IR34 1569 4.0e-172 G-protein-signaling modulator 1 OS=Mus musculus GN=Gpsm1 PE=1 SV=3 PF05194//PF10579//PF13181//PF07714//PF00069//PF13176//PF02104//PF13414//PF13374//PF04692//PF00515//PF02188//PF06293//PF00620 UreE urease accessory protein, C-terminal domain//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Protein tyrosine kinase//Protein kinase domain//Tetratricopeptide repeat//SURF1 family//TPR repeat//Tetratricopeptide repeat//Platelet-derived growth factor, N terminal region//Tetratricopeptide repeat//GoLoco motif//Lipopolysaccharide kinase (Kdo/WaaP) family//RhoGAP domain GO:0007165//GO:0006461//GO:0007268//GO:0006468//GO:0040007//GO:0008283//GO:0019627 signal transduction//protein complex assembly//synaptic transmission//protein phosphorylation//growth//cell proliferation//urea metabolic process GO:0005524//GO:0030695//GO:0016773//GO:0043495//GO:0004672//GO:0008083//GO:0033130//GO:0005515//GO:0016151 ATP binding//GTPase regulator activity//phosphotransferase activity, alcohol group as acceptor//protein anchor//protein kinase activity//growth factor activity//acetylcholine receptor binding//protein binding//nickel cation binding GO:0016020 membrane KOG1563 Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase Cluster-8309.40564 BP_3 110.52 2.35 2559 642933889 XP_008197555.1 1280 6.3e-138 PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum]>gi|642933891|ref|XP_008197556.1| PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40566 BP_3 24.78 1.58 1049 270013573 EFA10021.1 533 1.1e-51 hypothetical protein TcasGA2_TC012193 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05049//PF00437//PF00448//PF02421//PF03193//PF03266//PF00005//PF00493//PF04548//PF00071//PF00910//PF08477//PF00735//PF07728//PF01695//PF00158//PF01926//PF00004//PF02367//PF00503//PF01580 Interferon-inducible GTPase (IIGP)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//Ferrous iron transport protein B//Protein of unknown function, DUF258//NTPase//ABC transporter//MCM2/3/5 family//AIG1 family//Ras family//RNA helicase//Ras of Complex, Roc, domain of DAPkinase//Septin//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//G-protein alpha subunit//FtsK/SpoIIIE family GO:0007264//GO:0002949//GO:0006810//GO:0007165//GO:0006614//GO:0015684//GO:0006260//GO:0006355//GO:0007186 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//transport//signal transduction//SRP-dependent cotranslational protein targeting to membrane//ferrous iron transport//DNA replication//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway GO:0003677//GO:0003723//GO:0015093//GO:0003724//GO:0004871//GO:0005525//GO:0008134//GO:0003924//GO:0031683//GO:0098519//GO:0005524//GO:0019001//GO:0016887//GO:0000166 DNA binding//RNA binding//ferrous iron transmembrane transporter activity//RNA helicase activity//signal transducer activity//GTP binding//transcription factor binding//GTPase activity//G-protein beta/gamma-subunit complex binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//guanyl nucleotide binding//ATPase activity//nucleotide binding GO:0005667//GO:0016020//GO:0016021 transcription factor complex//membrane//integral component of membrane -- -- Cluster-8309.40568 BP_3 87.01 1.06 4243 91079794 XP_966414.1 2188 5.3e-243 PREDICTED: tyrosine-protein kinase Src64B [Tribolium castaneum]>gi|642918199|ref|XP_008191407.1| PREDICTED: tyrosine-protein kinase Src64B [Tribolium castaneum] 158295963 XM_316537.3 333 1.48377e-171 Anopheles gambiae str. PEST AGAP006510-PA (AgaP_AGAP006510) mRNA, complete cds K05704 SRC tyrosine-protein kinase Src http://www.genome.jp/dbget-bin/www_bget?ko:K05704 P00528 1938 2.1e-215 Tyrosine-protein kinase Src64B OS=Drosophila melanogaster GN=Src64B PE=1 SV=3 PF14604//PF00018//PF00069//PF07714 Variant SH3 domain//SH3 domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- -- -- Cluster-8309.40569 BP_3 3177.17 25.23 6362 270016366 EFA12812.1 562 2.8e-54 hypothetical protein TcasGA2_TC001877 [Tribolium castaneum] 642933104 XM_008199038.1 222 1.12948e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA K13199 SERBP1 plasminogen activator inhibitor 1 RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13199 Q9CY58 178 3.9e-11 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0000166//GO:0004814 ATP binding//nucleotide binding//arginine-tRNA ligase activity GO:0005737 cytoplasm KOG2945 Predicted RNA-binding protein Cluster-8309.40570 BP_3 993.45 6.01 8263 270014408 EFA10856.1 860 1.0e-88 hypothetical protein TcasGA2_TC001633 [Tribolium castaneum] 462278076 APGK01058768.1 96 1.62189e-39 Dendroctonus ponderosae Seq01058778, whole genome shotgun sequence -- -- -- -- Q05481 146 2.6e-07 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF16622//PF07776//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.40571 BP_3 122.00 11.41 807 270010810 EFA07258.1 304 2.9e-25 hypothetical protein TcasGA2_TC013289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40572 BP_3 407.93 6.40 3363 642926733 XP_008194990.1 2280 9.1e-254 PREDICTED: protein Malvolio isoform X2 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1804 5.9e-200 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF08089//PF01566//PF15168 Huwentoxin-II family//Natural resistance-associated macrophage protein//Triple QxxK/R motif-containing protein family GO:0006810//GO:0009405 transport//pathogenesis GO:0005215 transporter activity GO:0005576//GO:0016020//GO:0005789 extracellular region//membrane//endoplasmic reticulum membrane KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.40573 BP_3 256.59 1.18 10776 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.40574 BP_3 27.54 8.06 456 642919989 XP_008192156.1 530 1.0e-51 PREDICTED: teneurin-m isoform X1 [Tribolium castaneum]>gi|642919991|ref|XP_008192157.1| PREDICTED: teneurin-m isoform X1 [Tribolium castaneum]>gi|642919993|ref|XP_008192158.1| PREDICTED: teneurin-m isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40575 BP_3 589.91 2.86 10240 642919989 XP_008192156.1 10221 0.0e+00 PREDICTED: teneurin-m isoform X1 [Tribolium castaneum]>gi|642919991|ref|XP_008192157.1| PREDICTED: teneurin-m isoform X1 [Tribolium castaneum]>gi|642919993|ref|XP_008192158.1| PREDICTED: teneurin-m isoform X1 [Tribolium castaneum] 642919996 XM_008193938.1 1698 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 8820 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF07442//PF01436 Ponericin//NHL repeat -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.40576 BP_3 1794.16 10.62 8437 642924582 XP_001814936.2 11294 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 8 isoform X1 [Tribolium castaneum] 780624705 XM_011709832.1 94 2.14242e-38 PREDICTED: Wasmannia auropunctata multiple epidermal growth factor-like domains protein 8 (LOC105462915), mRNA -- -- -- -- P60882 2699 2.4e-303 Multiple epidermal growth factor-like domains protein 8 OS=Mus musculus GN=Megf8 PE=2 SV=2 PF01344//PF01437//PF16622//PF07646//PF07645 Kelch motif//Plexin repeat//zinc-finger C2H2-type//Kelch motif//Calcium-binding EGF domain -- -- GO:0005515//GO:0046872//GO:0005509 protein binding//metal ion binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.40578 BP_3 544.02 2.26 11893 642929438 XP_008195840.1 3313 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X1 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 2545 2.5e-285 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF12122//PF00520//PF00312//PF16519 Cytoplasmic N-terminal domain of rhomboid serine protease//Ion transport protein//Ribosomal protein S15//Tetramerisation domain of TRPM GO:0042254//GO:0006811//GO:0051262//GO:0055085//GO:0006412 ribosome biogenesis//ion transport//protein tetramerization//transmembrane transport//translation GO:0003735//GO:0005216//GO:0004252 structural constituent of ribosome//ion channel activity//serine-type endopeptidase activity GO:0005840//GO:0016020//GO:0005622//GO:0016021 ribosome//membrane//intracellular//integral component of membrane KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.40579 BP_3 961.39 12.85 3899 642916252 XP_008190947.1 2331 1.3e-259 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 94 9.8557e-39 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 578 9.9e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF12763//PF13405//PF00036//PF14604//PF13499//PF00018 Cytoskeletal-regulatory complex EF hand//EF-hand domain//EF hand//Variant SH3 domain//EF-hand domain pair//SH3 domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.40581 BP_3 3464.22 70.44 2662 478250527 ENN71022.1 1626 4.9e-178 hypothetical protein YQE_12421, partial [Dendroctonus ponderosae]>gi|546678988|gb|ERL89521.1| hypothetical protein D910_06887 [Dendroctonus ponderosae] 194745413 XM_001955147.1 241 1.28679e-120 Drosophila ananassae GF18634 (Dana\GF18634), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1361 1.1e-148 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.40582 BP_3 572.74 65.53 713 478250527 ENN71022.1 379 5.2e-34 hypothetical protein YQE_12421, partial [Dendroctonus ponderosae]>gi|546678988|gb|ERL89521.1| hypothetical protein D910_06887 [Dendroctonus ponderosae] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 Q4R6M5 254 6.7e-21 Probable ATP-dependent RNA helicase DDX5 OS=Macaca fascicularis GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.40583 BP_3 199.26 2.14 4774 546672885 ERL84608.1 3589 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1470 4.5e-161 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107//PF08545//PF00108 Zinc-binding dehydrogenase//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0055114//GO:0006633//GO:0008152 acyl-carrier-protein biosynthetic process//oxidation-reduction process//fatty acid biosynthetic process//metabolic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.40584 BP_3 852.89 31.14 1612 332376114 AEE63197.1 1491 1.3e-162 unknown [Dendroctonus ponderosae] 641676797 XM_008189320.1 35 2.52726e-06 PREDICTED: Acyrthosiphon pisum PDZ and LIM domain protein Zasp (LOC100162539), transcript variant X5, mRNA -- -- -- -- A1ZA47 900 1.9e-95 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF00412//PF13180//PF02843 PDZ domain (Also known as DHR or GLGF)//LIM domain//PDZ domain//Phosphoribosylglycinamide synthetase, C domain GO:0006144//GO:0009113 purine nucleobase metabolic process//purine nucleobase biosynthetic process GO:0005515//GO:0008270//GO:0004637 protein binding//zinc ion binding//phosphoribosylamine-glycine ligase activity -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40585 BP_3 3.28 0.57 569 270007560 EFA04008.1 507 6.0e-49 hypothetical protein TcasGA2_TC014157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 8.8e-24 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.40586 BP_3 137.35 2.67 2770 91083989 XP_975221.1 158 8.6e-08 PREDICTED: CKLF-like MARVEL transmembrane domain-containing protein 8 [Tribolium castaneum]>gi|270007988|gb|EFA04436.1| hypothetical protein TcasGA2_TC014737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.40588 BP_3 798.89 7.39 5502 642931601 XP_008196651.1 4418 0.0e+00 PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum]>gi|642931603|ref|XP_008196652.1| PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum] 723941700 KF986386.1 853 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3318 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02170//PF02171//PF04810 PAZ domain//Piwi domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270//GO:0005515 nucleic acid binding//zinc ion binding//protein binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.40589 BP_3 10.31 0.38 1598 649572321 NP_001280510.1 952 4.2e-100 AP-2 complex subunit mu [Tribolium castaneum]>gi|270013333|gb|EFA09781.1| hypothetical protein TcasGA2_TC011923 [Tribolium castaneum]>gi|629511283|gb|AHY84715.1| AP-2 complex subunit mu [Tribolium castaneum] 805795269 XM_003704189.2 204 2.83266e-100 PREDICTED: Megachile rotundata AP-2 complex subunit mu (LOC100875683), mRNA K11826 AP2M1 AP-2 complex subunit mu-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11826 Q5ZMP6 891 2.1e-94 AP-2 complex subunit mu OS=Gallus gallus GN=AP2M1 PE=2 SV=1 -- -- GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport -- -- GO:0030132//GO:0030131 clathrin coat of coated pit//clathrin adaptor complex KOG0937 Adaptor complexes medium subunit family Cluster-8309.40591 BP_3 1485.79 12.16 6180 478260998 ENN80588.1 6814 0.0e+00 hypothetical protein YQE_02993, partial [Dendroctonus ponderosae] 884965815 XM_010892944.2 162 2.47869e-76 PREDICTED: Esox lucius HECT domain containing E3 ubiquitin protein ligase 1 (hectd1), transcript variant X6, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 4691 0.0e+00 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF06701//PF13606//PF00023 Mib_herc2//Ankyrin repeat//Ankyrin repeat GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515 ubiquitin-protein transferase activity//metal ion binding//protein binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.40594 BP_3 225.63 1.82 6270 642928815 XP_967995.2 1339 2.2e-144 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 167 7.2e-10 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40596 BP_3 680.61 8.12 4330 189235866 XP_969616.2 4859 0.0e+00 PREDICTED: pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [Tribolium castaneum]>gi|270004535|gb|EFA00983.1| hypothetical protein TcasGA2_TC003896 [Tribolium castaneum] 242012722 XM_002427032.1 602 0 Pediculus humanus corporis splicing factor ATP-dependent RNA helicase prp16, putative, mRNA K12815 DHX38, PRP16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 http://www.genome.jp/dbget-bin/www_bget?ko:K12815 Q92620 3643 0.0e+00 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens GN=DHX38 PE=1 SV=2 PF04408//PF02407//PF00437//PF00448//PF00005//PF01637//PF02562//PF00270//PF07652//PF00931 Helicase associated domain (HA2)//Putative viral replication protein//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//ABC transporter//Archaeal ATPase//PhoH-like protein//DEAD/DEAH box helicase//Flavivirus DEAD domain//NB-ARC domain GO:0006810//GO:0006614//GO:0019079//GO:0006260//GO:0018142//GO:0006144//GO:0006308 transport//SRP-dependent cotranslational protein targeting to membrane//viral genome replication//DNA replication//protein-DNA covalent cross-linking//purine nucleobase metabolic process//DNA catabolic process GO:0005524//GO:0016779//GO:0016887//GO:0008026//GO:0043531//GO:0016888//GO:0004386//GO:0005525//GO:0042624//GO:0003676 ATP binding//nucleotidyltransferase activity//ATPase activity//ATP-dependent helicase activity//ADP binding//endodeoxyribonuclease activity, producing 5'-phosphomonoesters//helicase activity//GTP binding//ATPase activity, uncoupled//nucleic acid binding -- -- KOG0924 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.40597 BP_3 956.05 16.45 3093 642939832 XP_008190719.1 946 4.1e-99 PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum]>gi|642939834|ref|XP_008190783.1| PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYP4 306 2.7e-26 Zinc finger C2HC domain-containing protein 1C OS=Rattus norvegicus GN=Zc2hc1c PE=2 SV=1 PF03884//PF16622//PF05191//PF00096//PF13465//PF02313//PF01155 Domain of unknown function (DUF329)//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Zinc-finger double domain//Fumarate reductase subunit D//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0046034//GO:0006144//GO:0006464//GO:0006106 ATP metabolic process//purine nucleobase metabolic process//cellular protein modification process//fumarate metabolic process GO:0016151//GO:0004017//GO:0046872//GO:0008270 nickel cation binding//adenylate kinase activity//metal ion binding//zinc ion binding GO:0016020 membrane KOG3940 Uncharacterized conserved protein Cluster-8309.40598 BP_3 555.07 15.56 2011 91077452 XP_967401.1 1566 3.4e-171 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270001620|gb|EEZ98067.1| hypothetical protein TcasGA2_TC000474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02338 463 1.1e-44 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3 PF01370//PF13676//PF00106 NAD dependent epimerase/dehydratase family//TIR domain//short chain dehydrogenase GO:0055114//GO:0007165//GO:0008152 oxidation-reduction process//signal transduction//metabolic process GO:0000166//GO:0003824//GO:0050662//GO:0016491//GO:0005515 nucleotide binding//catalytic activity//coenzyme binding//oxidoreductase activity//protein binding -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.40600 BP_3 39.76 6.56 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40601 BP_3 16.39 0.67 1466 91085847 XP_974980.1 899 5.4e-94 PREDICTED: LIM and SH3 domain protein F42H10.3 [Tribolium castaneum]>gi|270010142|gb|EFA06590.1| hypothetical protein TcasGA2_TC009504 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7C3 622 2.9e-63 LIM and SH3 domain protein Lasp OS=Drosophila melanogaster GN=Lasp PE=1 SV=2 PF00412 LIM domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1702 Nebulin repeat protein Cluster-8309.40602 BP_3 3.21 0.41 674 91092692 XP_971829.1 182 3.4e-11 PREDICTED: uncharacterized protein LOC660509 [Tribolium castaneum]>gi|642911393|ref|XP_008199405.1| PREDICTED: uncharacterized protein LOC660509 [Tribolium castaneum]>gi|270015139|gb|EFA11587.1| immune deficiency [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40603 BP_3 1551.86 9.31 8328 270015064 EFA11512.1 6503 0.0e+00 hypothetical protein TcasGA2_TC014226 [Tribolium castaneum] 665815330 XM_008558095.1 187 4.23465e-90 PREDICTED: Microplitis demolitor kinesin-like protein KIF13A (LOC103577457), transcript variant X3, mRNA K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 Q9H1H9 3358 0.0e+00 Kinesin-like protein KIF13A OS=Homo sapiens GN=KIF13A PE=1 SV=2 PF01496//PF00498//PF00225 V-type ATPase 116kDa subunit family//FHA domain//Kinesin motor domain GO:0007018//GO:0015991//GO:0007017//GO:0015992 microtubule-based movement//ATP hydrolysis coupled proton transport//microtubule-based process//proton transport GO:0005524//GO:0003777//GO:0005515//GO:0015078//GO:0008017 ATP binding//microtubule motor activity//protein binding//hydrogen ion transmembrane transporter activity//microtubule binding GO:0005874//GO:0045298//GO:0033179 microtubule//tubulin complex//proton-transporting V-type ATPase, V0 domain KOG0241 Kinesin-like protein Cluster-8309.40604 BP_3 7943.00 201.05 2196 268607717 NP_001161316.1 503 6.7e-48 cuticular protein precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.40605 BP_3 771.89 3.48 10989 270015064 EFA11512.1 6011 0.0e+00 hypothetical protein TcasGA2_TC014226 [Tribolium castaneum] 642910931 XM_008195249.1 802 0 PREDICTED: Tribolium castaneum kinesin 3A (LOC661047), transcript variant X3, mRNA K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 Q9H1H9 3867 0.0e+00 Kinesin-like protein KIF13A OS=Homo sapiens GN=KIF13A PE=1 SV=2 PF01496//PF00225//PF01499//PF00498 V-type ATPase 116kDa subunit family//Kinesin motor domain//Herpesvirus UL25 family//FHA domain GO:0015992//GO:0007017//GO:0015991//GO:0019072//GO:0007018 proton transport//microtubule-based process//ATP hydrolysis coupled proton transport//viral genome packaging//microtubule-based movement GO:0008017//GO:0015078//GO:0003777//GO:0005515//GO:0005524 microtubule binding//hydrogen ion transmembrane transporter activity//microtubule motor activity//protein binding//ATP binding GO:0033179//GO:0045298//GO:0005874//GO:0042025 proton-transporting V-type ATPase, V0 domain//tubulin complex//microtubule//host cell nucleus KOG0241 Kinesin-like protein Cluster-8309.40608 BP_3 265.77 1.07 12222 270015676 EFA12124.1 1367 2.4e-147 hypothetical protein TcasGA2_TC002270 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643//PF05485 B-box zinc finger//THAP domain -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.40612 BP_3 548.28 7.55 3793 642912192 XP_008200846.1 754 9.1e-77 PREDICTED: transmembrane protein 127-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q504G0 216 9.1e-16 Transmembrane protein 127 OS=Danio rerio GN=tmem127 PE=2 SV=1 PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.40613 BP_3 22.33 0.38 3127 642933047 XP_971594.2 1327 2.7e-143 PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum]>gi|642933049|ref|XP_008197242.1| PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum] -- -- -- -- -- K03372 ACATN, SLC33A1 MFS transporter, PAT family, solute carrier family 33 (acetyl-CoA transportor), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03372 Q6AYY8 933 5.4e-99 Acetyl-coenzyme A transporter 1 OS=Rattus norvegicus GN=Slc33a1 PE=2 SV=1 PF05656//PF07690//PF13000 Protein of unknown function (DUF805)//Major Facilitator Superfamily//Acetyl-coenzyme A transporter 1 GO:0015876//GO:0055085 acetyl-CoA transport//transmembrane transport GO:0008521 acetyl-CoA transporter activity GO:0016021 integral component of membrane KOG3574 Acetyl-CoA transporter Cluster-8309.40614 BP_3 16.00 1.09 998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40615 BP_3 73.13 0.60 6212 642911186 XP_008199538.1 4691 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911188|ref|XP_008199542.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911190|ref|XP_008199549.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911192|ref|XP_008199550.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum] 820840417 XM_012495626.1 165 5.35534e-78 PREDICTED: Apis florea inositol 1,4,5-trisphosphate receptor (LOC100870897), mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 3729 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF00520//PF07822 Ion transport protein//Neurotoxin B-IV-like protein GO:0006810//GO:0055085//GO:0009405//GO:0006811 transport//transmembrane transport//pathogenesis//ion transport GO:0019871//GO:0005216 sodium channel inhibitor activity//ion channel activity GO:0016020//GO:0005576 membrane//extracellular region KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.40616 BP_3 67.34 0.32 10320 642911194 XP_008199555.1 6749 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X2 [Tribolium castaneum] 805816096 XM_012293285.1 429 0 PREDICTED: Megachile rotundata inositol 1,4,5-trisphosphate receptor (LOC100879087), transcript variant X4, mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 5050 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF02815//PF00520//PF01365 MIR domain//Ion transport protein//RIH domain GO:0006811//GO:0070588//GO:0006816//GO:0055085 ion transport//calcium ion transmembrane transport//calcium ion transport//transmembrane transport GO:0005262//GO:0005216 calcium channel activity//ion channel activity GO:0016020 membrane KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.40617 BP_3 142.31 1.33 5463 642917535 XP_008191244.1 6083 0.0e+00 PREDICTED: protein TANC2 isoform X1 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.10108e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 9.9e-282 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF13414//PF02376//PF13639//PF01637//PF00023//PF00004//PF13606//PF07728 TPR repeat//CUT domain//Ring finger domain//Archaeal ATPase//Ankyrin repeat//ATPase family associated with various cellular activities (AAA)//Ankyrin repeat//AAA domain (dynein-related subfamily) -- -- GO:0005515//GO:0016887//GO:0003677//GO:0005524//GO:0008270 protein binding//ATPase activity//DNA binding//ATP binding//zinc ion binding -- -- -- -- Cluster-8309.4062 BP_3 6.66 1.19 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40620 BP_3 16.00 0.60 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF06632 Oxaloacetate decarboxylase, gamma chain//DNA double-strand break repair and V(D)J recombination protein XRCC4 GO:0006525//GO:0006560//GO:0006310//GO:0006814//GO:0071436//GO:0006090//GO:0006302 arginine metabolic process//proline metabolic process//DNA recombination//sodium ion transport//sodium ion export//pyruvate metabolic process//double-strand break repair GO:0003677//GO:0008948//GO:0015081 DNA binding//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.40621 BP_3 410.81 1.51 13439 478257788 ENN77931.1 3951 0.0e+00 hypothetical protein YQE_05608, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 435 1.3e-40 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF10034//PF13606//PF00023 Q-cell neuroblast polarisation//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.40622 BP_3 169.59 1.79 4862 642926255 XP_008194846.1 2748 7.1e-308 PREDICTED: kelch-like protein 17 [Tribolium castaneum]>gi|270008515|gb|EFA04963.1| hypothetical protein TcasGA2_TC015037 [Tribolium castaneum] 195029940 XM_001987794.1 64 5.85138e-22 Drosophila grimshawi GH19736 (Dgri\GH19736), mRNA K10454 KLHL17 kelch-like protein 17 (actinfilin) http://www.genome.jp/dbget-bin/www_bget?ko:K10454 Q6TDP3 1717 1.0e-189 Kelch-like protein 17 OS=Mus musculus GN=Klhl17 PE=2 SV=1 PF00884//PF07646//PF00651//PF01344 Sulfatase//Kelch motif//BTB/POZ domain//Kelch motif GO:0008152 metabolic process GO:0005515//GO:0008484 protein binding//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.40626 BP_3 840.19 6.16 6863 642921007 XP_008192651.1 2135 1.2e-236 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 2.79219e-66 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7RTS6 149 9.7e-08 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 PF01499 Herpesvirus UL25 family GO:0019072 viral genome packaging -- -- GO:0042025 host cell nucleus KOG4740 Uncharacterized conserved protein Cluster-8309.40627 BP_3 802.67 6.48 6262 478255994 ENN76193.1 2025 6.3e-224 hypothetical protein YQE_07161, partial [Dendroctonus ponderosae] -- -- -- -- -- K11423 SETD2, SET2 histone-lysine N-methyltransferase SETD2 http://www.genome.jp/dbget-bin/www_bget?ko:K11423 Q9VYD1 849 6.0e-89 Probable histone-lysine N-methyltransferase CG1716 OS=Drosophila melanogaster GN=Set2 PE=1 SV=2 PF15761//PF00856//PF08236//PF00397 Immortalisation up-regulated protein//SET domain//SRI (Set2 Rpb1 interacting) domain//WW domain GO:0006355//GO:0006479//GO:0006554//GO:0034968 regulation of transcription, DNA-templated//protein methylation//lysine catabolic process//histone lysine methylation GO:0018024//GO:0005515 histone-lysine N-methyltransferase activity//protein binding GO:0005694//GO:0005634 chromosome//nucleus KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.40628 BP_3 44.00 15.59 427 91084765 XP_972022.1 379 3.1e-34 PREDICTED: cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [Tribolium castaneum]>gi|270008948|gb|EFA05396.1| hypothetical protein TcasGA2_TC015568 [Tribolium castaneum] -- -- -- -- -- K18182 COX16 cytochrome c oxidase assembly protein subunit 16 http://www.genome.jp/dbget-bin/www_bget?ko:K18182 Q9P0S2 206 1.5e-15 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Homo sapiens GN=COX16 PE=3 SV=1 PF14138//PF00322 Cytochrome c oxidase assembly protein COX16//Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0031966//GO:0005576 mitochondrial membrane//extracellular region -- -- Cluster-8309.40629 BP_3 17.00 1.05 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40633 BP_3 605.52 6.34 4898 91084547 XP_973113.1 3577 0.0e+00 PREDICTED: protein unc-45 homolog B [Tribolium castaneum]>gi|270009248|gb|EFA05696.1| translocase of outer membrane 34 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F64 1674 1.0e-184 Protein unc-45 homolog B OS=Xenopus laevis GN=unc45b PE=2 SV=1 PF13371//PF00515//PF13374//PF13176//PF03152//PF08718//PF13414//PF13181//PF00839//PF00514 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Ubiquitin fusion degradation protein UFD1//Glycolipid transfer protein (GLTP)//TPR repeat//Tetratricopeptide repeat//Cysteine rich repeat//Armadillo/beta-catenin-like repeat GO:0006511//GO:0046836 ubiquitin-dependent protein catabolic process//glycolipid transport GO:0017089//GO:0051861//GO:0005515 glycolipid transporter activity//glycolipid binding//protein binding GO:0016020//GO:0005737 membrane//cytoplasm KOG1816 Ubiquitin fusion-degradation protein Cluster-8309.40635 BP_3 54.94 2.09 1556 282158091 NP_001164089.1 698 1.2e-70 farnesyl pyrophosphate synthase [Tribolium castaneum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P14324 435 1.5e-41 Farnesyl pyrophosphate synthase OS=Homo sapiens GN=FDPS PE=1 SV=4 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.40637 BP_3 245.29 16.96 989 449139004 AGE89831.1 882 3.4e-92 isoprenyl diphosphate synthase [Phaedon cochleariae] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P08836 490 4.0e-48 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.40639 BP_3 21.08 0.58 2029 768443595 XP_011563618.1 843 2.3e-87 PREDICTED: uncharacterized protein LOC105393537 [Plutella xylostella] -- -- -- -- -- -- -- -- -- P03352 132 2.7e-06 Gag polyprotein OS=Maedi visna virus (strain 1514) GN=gag PE=3 SV=1 PF00098//PF09668 Zinc knuckle//Aspartyl protease GO:0006508 proteolysis GO:0003676//GO:0004190//GO:0008270 nucleic acid binding//aspartic-type endopeptidase activity//zinc ion binding -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.40641 BP_3 1181.73 8.79 6770 642934517 XP_008197696.1 5483 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein Mi-2 homolog isoform X1 [Tribolium castaneum]>gi|270013510|gb|EFA09958.1| hypothetical protein TcasGA2_TC012115 [Tribolium castaneum] 815926192 XM_012392264.1 601 0 PREDICTED: Bombus impatiens chromodomain-helicase-DNA-binding protein Mi-2 homolog (LOC100740721), transcript variant X10, mRNA K11643 CHD4, MI2B chromodomain-helicase-DNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11643 O97159 4696 0.0e+00 Chromodomain-helicase-DNA-binding protein Mi-2 homolog OS=Drosophila melanogaster GN=Mi-2 PE=1 SV=2 PF00628//PF00001//PF06357//PF00130//PF08073//PF00641//PF04851//PF00176//PF00270//PF08074 PHD-finger//7 transmembrane receptor (rhodopsin family)//Omega-atracotoxin//Phorbol esters/diacylglycerol binding domain (C1 domain)//CHDNT (NUC034) domain//Zn-finger in Ran binding protein and others//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//DEAD/DEAH box helicase//CHDCT2 (NUC038) domain GO:0006810//GO:0006952//GO:0009405//GO:0035556//GO:0006355//GO:0007186 transport//defense response//pathogenesis//intracellular signal transduction//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway GO:0016787//GO:0005524//GO:0019855//GO:0016818//GO:0008270//GO:0005515//GO:0004930//GO:0003677//GO:0004386//GO:0003676//GO:0043169 hydrolase activity//ATP binding//calcium channel inhibitor activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//protein binding//G-protein coupled receptor activity//DNA binding//helicase activity//nucleic acid binding//cation binding GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG0383 Predicted helicase Cluster-8309.40642 BP_3 95.06 0.90 5401 642925447 XP_008194558.1 454 8.0e-42 PREDICTED: cellular FABP-like protein isoform X2 [Tribolium castaneum] 797056877 HG313989.1 36 2.38976e-06 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 11 K08756 FABP7 fatty acid-binding protein 7, brain http://www.genome.jp/dbget-bin/www_bget?ko:K08756 A6YLM6 230 3.1e-17 Fatty acid-binding protein, adipocyte OS=Cervus elaphus GN=FABP4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.40644 BP_3 28.23 1.81 1044 270009349 EFA05797.1 610 1.3e-60 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 319 2.9e-28 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.40646 BP_3 628.37 8.42 3887 641664379 XP_001943157.3 2635 7.2e-295 PREDICTED: FERM, RhoGEF and pleckstrin domain-containing protein 2 [Acyrthosiphon pisum] 751460266 XM_011186586.1 188 5.47046e-91 PREDICTED: Bactrocera cucurbitae FERM, RhoGEF and pleckstrin domain-containing protein 2-like (LOC105213626), transcript variant X3, mRNA K06082 FARP2, FRG FERM, RhoGEF and pleckstrin domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06082 Q91VS8 1096 8.5e-118 FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Mus musculus GN=Farp2 PE=1 SV=2 PF08172//PF00621 CASP C terminal//RhoGEF domain GO:0043087//GO:0035023//GO:0006891 regulation of GTPase activity//regulation of Rho protein signal transduction//intra-Golgi vesicle-mediated transport GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0030173 integral component of Golgi membrane KOG3531 Rho guanine nucleotide exchange factor CDEP Cluster-8309.40648 BP_3 1083.48 32.70 1889 91080555 XP_967130.1 722 2.3e-73 PREDICTED: clathrin light chain isoform X1 [Tribolium castaneum] -- -- -- -- -- K04644 CLTA, LCA clathrin light chain A http://www.genome.jp/dbget-bin/www_bget?ko:K04644 Q9VWA1 368 1.1e-33 Clathrin light chain OS=Drosophila melanogaster GN=Clc PE=2 SV=1 PF13855//PF01086 Leucine rich repeat//Clathrin light chain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle -- -- Cluster-8309.40650 BP_3 147.01 1.03 7147 642920624 XP_008192494.1 1089 2.5e-115 PREDICTED: glycosyltransferase-like protein LARGE2 [Tribolium castaneum] -- -- -- -- -- K09668 LARGE glycosyltransferase-like protein LARGE http://www.genome.jp/dbget-bin/www_bget?ko:K09668 Q66PG3 757 3.2e-78 Glycosyltransferase-like protein LARGE1 OS=Gallus gallus GN=LARGE PE=2 SV=1 PF01545//PF09329//PF01501//PF00957//PF00711 Cation efflux family//Primase zinc finger//Glycosyl transferase family 8//Synaptobrevin//Beta defensin GO:0006260//GO:0006812//GO:0055085//GO:0016192//GO:0006952 DNA replication//cation transport//transmembrane transport//vesicle-mediated transport//defense response GO:0008324//GO:0016757 cation transmembrane transporter activity//transferase activity, transferring glycosyl groups GO:0005576//GO:0005634//GO:0016021 extracellular region//nucleus//integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.40653 BP_3 715.01 5.02 7153 91088357 XP_971705.1 1276 5.1e-137 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|270011777|gb|EFA08225.1| hypothetical protein TcasGA2_TC005852 [Tribolium castaneum] -- -- -- -- -- K17232 DUOXA2 dual oxidase maturation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17232 Q6DDK3 372 1.4e-33 Dual oxidase maturation factor 1 OS=Xenopus laevis GN=duoxa1 PE=2 SV=1 PF00096//PF01283//PF04062//PF17123//PF10204//PF00651 Zinc finger, C2H2 type//Ribosomal protein S26e//ARP2/3 complex ARPC3 (21 kDa) subunit//RING-like zinc finger//Dual oxidase maturation factor//BTB/POZ domain GO:0030833//GO:0034314//GO:0015031//GO:0042254//GO:0006412 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation//protein transport//ribosome biogenesis//translation GO:0003735//GO:0008270//GO:0005515//GO:0046872 structural constituent of ribosome//zinc ion binding//protein binding//metal ion binding GO:0016021//GO:0005622//GO:0005885//GO:0005840//GO:0005856//GO:0005789//GO:0044425 integral component of membrane//intracellular//Arp2/3 protein complex//ribosome//cytoskeleton//endoplasmic reticulum membrane//membrane part -- -- Cluster-8309.40655 BP_3 156.00 14.02 828 91082307 XP_974197.1 721 1.3e-73 PREDICTED: inosine triphosphate pyrophosphatase [Tribolium castaneum]>gi|270007471|gb|EFA03919.1| hypothetical protein TcasGA2_TC014054 [Tribolium castaneum] -- -- -- -- -- K01519 ITPA inosine triphosphate pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01519 Q7Q4F5 688 3.7e-71 Inosine triphosphate pyrophosphatase OS=Anopheles gambiae GN=AGAP008374 PE=3 SV=2 PF01725 Ham1 family -- -- GO:0016787 hydrolase activity -- -- KOG3222 Inosine triphosphate pyrophosphatase Cluster-8309.40657 BP_3 2211.00 11.32 9706 817084369 XP_012264833.1 1743 4.9e-191 PREDICTED: cAMP-dependent protein kinase catalytic subunit [Athalia rosae] 462451100 APGK01007788.1 477 0 Dendroctonus ponderosae Seq01007796, whole genome shotgun sequence K04345 PKA protein kinase A http://www.genome.jp/dbget-bin/www_bget?ko:K04345 P12370 1693 1.3e-186 cAMP-dependent protein kinase catalytic subunit OS=Drosophila melanogaster GN=Pka-C1 PE=1 SV=3 PF00069//PF05933//PF07714 Protein kinase domain//Fungal ATP synthase protein 8 (A6L)//Protein tyrosine kinase GO:0015992//GO:0006468//GO:0015986 proton transport//protein phosphorylation//ATP synthesis coupled proton transport GO:0004672//GO:0005524//GO:0015078 protein kinase activity//ATP binding//hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA) Cluster-8309.40658 BP_3 83.17 0.92 4666 642915296 XP_008190559.1 391 1.4e-34 PREDICTED: signal recognition particle 9 kDa protein [Tribolium castaneum]>gi|270004979|gb|EFA01427.1| hypothetical protein TcasGA2_TC030568 [Tribolium castaneum] -- -- -- -- -- K03109 SRP9 signal recognition particle subunit SRP9 http://www.genome.jp/dbget-bin/www_bget?ko:K03109 Q9VSC1 231 2.0e-17 Signal recognition particle 9 kDa protein OS=Drosophila melanogaster GN=Srp9 PE=3 SV=1 -- -- GO:0006614//GO:0045900 SRP-dependent cotranslational protein targeting to membrane//negative regulation of translational elongation GO:0008312 7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3465 Signal recognition particle, subunit Srp9 Cluster-8309.40660 BP_3 119.01 1.83 3424 642924809 XP_008194049.1 3098 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X1 [Tribolium castaneum] 195497284 XM_002095999.1 117 1.41604e-51 Drosophila yakuba GE25295 (Dyak\GE25295), partial mRNA -- -- -- -- Q5ZMS4 324 2.5e-28 Nuclear receptor coactivator 7 OS=Gallus gallus GN=NCOA7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.40662 BP_3 43.97 0.31 7079 642912571 XP_008200914.1 1719 2.2e-188 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 141 1.34019e-64 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 890 1.2e-93 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF00617//PF03278//PF02252//PF03425 RasGEF domain//IpaB/EvcA family//Proteasome activator pa28 beta subunit//Carbohydrate binding domain (family 11) GO:0043087//GO:0007264//GO:0030245//GO:0005985//GO:0005982//GO:0009405 regulation of GTPase activity//small GTPase mediated signal transduction//cellulose catabolic process//sucrose metabolic process//starch metabolic process//pathogenesis GO:0008810//GO:0005085 cellulase activity//guanyl-nucleotide exchange factor activity GO:0008537 proteasome activator complex KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.40663 BP_3 628.20 4.62 6842 642912571 XP_008200914.1 1898 3.7e-209 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 195 1.24126e-94 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 1025 2.6e-109 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF03425//PF00617//PF03278 Carbohydrate binding domain (family 11)//RasGEF domain//IpaB/EvcA family GO:0043087//GO:0030245//GO:0007264//GO:0005985//GO:0009405//GO:0005982 regulation of GTPase activity//cellulose catabolic process//small GTPase mediated signal transduction//sucrose metabolic process//pathogenesis//starch metabolic process GO:0005085//GO:0008810 guanyl-nucleotide exchange factor activity//cellulase activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.40664 BP_3 354.89 3.06 5881 642912571 XP_008200914.1 1898 3.1e-209 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 195 1.06649e-94 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 1025 2.2e-109 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF00617 RasGEF domain GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.40668 BP_3 64.36 0.66 4971 642924676 XP_008194392.1 1124 1.5e-119 PREDICTED: voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [Tribolium castaneum] 642924683 XM_008196175.1 235 5.23096e-117 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X5, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 839 6.9e-88 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.40669 BP_3 814.79 5.63 7271 91079915 XP_967163.1 3071 0.0e+00 PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|642918342|ref|XP_008196887.1| PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|270003264|gb|EEZ99711.1| hypothetical protein TcasGA2_TC002472 [Tribolium castaneum] 642918340 XM_962070.3 658 0 PREDICTED: Tribolium castaneum cold shock domain-containing protein E1 (LOC655517), transcript variant X1, mRNA -- -- -- -- P18395 1330 1.2e-144 Cold shock domain-containing protein E1 OS=Rattus norvegicus GN=Csde1 PE=2 SV=1 PF00313//PF02099 'Cold-shock' DNA-binding domain//Josephin GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008242 DNA binding//omega peptidase activity -- -- KOG2935 Ataxin 3/Josephin Cluster-8309.40670 BP_3 7.15 0.67 803 291170320 ADD82416.1 198 5.7e-13 minus-C odorant binding protein 3 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40672 BP_3 624.00 74.58 695 758343053 AJO67868.1 391 2.1e-35 odorant binding protein 6 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.40673 BP_3 372.75 6.02 3277 91080113 XP_967415.1 1588 1.5e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit I [Tribolium castaneum]>gi|270003188|gb|EEZ99635.1| hypothetical protein TcasGA2_TC002391 [Tribolium castaneum] 642918634 XM_962322.2 236 9.55161e-118 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 3 subunit I (LOC655760), mRNA K03246 EIF3I translation initiation factor 3 subunit I http://www.genome.jp/dbget-bin/www_bget?ko:K03246 Q1HPW4 1315 2.9e-143 Eukaryotic translation initiation factor 3 subunit I OS=Bombyx mori PE=2 SV=1 PF00400//PF10505//PF10766//PF04053 WD domain, G-beta repeat//NMDA receptor-regulated gene protein 2 C-terminus//Multidrug efflux pump-associated protein AcrZ//Coatomer WD associated region GO:0015893//GO:0006886//GO:0016192//GO:0006855 drug transport//intracellular protein transport//vesicle-mediated transport//drug transmembrane transport GO:0015238//GO:0005515//GO:0005198 drug transmembrane transporter activity//protein binding//structural molecule activity GO:0030117//GO:0005886//GO:0008023 membrane coat//plasma membrane//transcription elongation factor complex KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) Cluster-8309.40674 BP_3 4124.16 76.45 2892 189238197 XP_001807880.1 3338 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|642925484|ref|XP_008194570.1| PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|270008848|gb|EFA05296.1| hypothetical protein TcasGA2_TC015453 [Tribolium castaneum] 755988497 XM_011313566.1 299 8.0103e-153 PREDICTED: Fopius arisanus eukaryotic translation initiation factor 3 subunit C (LOC105271805), mRNA K03252 EIF3C translation initiation factor 3 subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K03252 Q17Q06 2672 1.1e-300 Eukaryotic translation initiation factor 3 subunit C OS=Aedes aegypti GN=eIF3-S8 PE=3 SV=1 PF01399//PF05470 PCI domain//Eukaryotic translation initiation factor 3 subunit 8 N-terminus GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0005515//GO:0003743//GO:0031369 protein binding//translation initiation factor activity//translation initiation factor binding GO:0005852//GO:0005840 eukaryotic translation initiation factor 3 complex//ribosome KOG1076 Translation initiation factor 3, subunit c (eIF-3c) Cluster-8309.40682 BP_3 2016.91 28.86 3660 642931127 XP_008201673.1 3349 0.0e+00 PREDICTED: uncharacterized protein LOC655872 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40688 BP_3 106.52 1.48 3763 91083631 XP_970382.1 2205 5.1e-245 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.49299e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 1600 3.0e-176 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF03188//PF02826//PF01752//PF00205//PF07074//PF00107//PF00005//PF02233 Eukaryotic cytochrome b561//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Collagenase//Thiamine pyrophosphate enzyme, central domain//Translocon-associated protein, gamma subunit (TRAP-gamma)//Zinc-binding dehydrogenase//ABC transporter//NAD(P) transhydrogenase beta subunit GO:0006508//GO:0055114//GO:0006769//GO:0015992//GO:0046497//GO:0006613 proteolysis//oxidation-reduction process//nicotinamide metabolic process//proton transport//nicotinate nucleotide metabolic process//cotranslational protein targeting to membrane GO:0030976//GO:0000287//GO:0051287//GO:0050661//GO:0004252//GO:0008270//GO:0016887//GO:0008750//GO:0005524 thiamine pyrophosphate binding//magnesium ion binding//NAD binding//NADP binding//serine-type endopeptidase activity//zinc ion binding//ATPase activity//NAD(P)+ transhydrogenase (AB-specific) activity//ATP binding GO:0005576//GO:0005784//GO:0030176//GO:0016021 extracellular region//Sec61 translocon complex//integral component of endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.40689 BP_3 1423.51 16.57 4432 91091360 XP_972551.1 1769 2.1e-194 PREDICTED: 26S protease regulatory subunit 8 [Tribolium castaneum] 242005916 XM_002423761.1 495 0 Pediculus humanus corporis 26S protease regulatory subunit, putative, mRNA K03066 PSMC5, RPT6 26S proteasome regulatory subunit T6 http://www.genome.jp/dbget-bin/www_bget?ko:K03066 O18413 1711 4.7e-189 26S protease regulatory subunit 8 OS=Drosophila melanogaster GN=Rpt6 PE=1 SV=2 PF00004//PF07724//PF07728//PF01695//PF06068//PF00158//PF01057//PF05496//PF00910//PF07726//PF02367//PF06414//PF02562 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//TIP49 C-terminus//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//RNA helicase//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein GO:0002949//GO:0006310//GO:0006355//GO:0019079//GO:0006281 tRNA threonylcarbamoyladenosine modification//DNA recombination//regulation of transcription, DNA-templated//viral genome replication//DNA repair GO:0009378//GO:0003724//GO:0003678//GO:0003723//GO:0016301//GO:0016887//GO:0005524//GO:0008134 four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding//kinase activity//ATPase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0728 26S proteasome regulatory complex, ATPase RPT6 Cluster-8309.40690 BP_3 240.11 1.92 6316 642936704 XP_008198546.1 2613 4.2e-292 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P07207 158 8.1e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF13895//PF02793//PF00008 Immunoglobulin domain//Hormone receptor domain//EGF-like domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016020 membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.40691 BP_3 260.88 3.32 4076 642914748 XP_008190336.1 5338 0.0e+00 PREDICTED: potassium channel subfamily T member 2 [Tribolium castaneum] 642914747 XM_008192114.1 1137 0 PREDICTED: Tribolium castaneum potassium channel subfamily T member 2 (LOC655919), mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q8QFV0 1603 1.4e-176 Potassium channel subfamily T member 1 OS=Gallus gallus GN=KCNT1 PE=2 SV=1 PF03493//PF00520 Calcium-activated BK potassium channel alpha subunit//Ion transport protein GO:0006813//GO:0006811//GO:0055085 potassium ion transport//ion transport//transmembrane transport GO:0015269//GO:0005216 calcium-activated potassium channel activity//ion channel activity GO:0016020 membrane KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.40692 BP_3 35.91 1.34 1583 270297202 NP_001161902.1 1698 1.3e-186 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 1286 3.2e-140 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 PF02602 Uroporphyrinogen-III synthase HemD GO:0033014//GO:0006783//GO:0015994//GO:0008152 tetrapyrrole biosynthetic process//heme biosynthetic process//chlorophyll metabolic process//metabolic process GO:0004852//GO:0033961 uroporphyrinogen-III synthase activity//cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.40693 BP_3 130.44 4.53 1681 91094771 XP_967866.1 1686 3.4e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.3e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.40696 BP_3 1405.04 8.58 8182 270016796 EFA13242.1 3554 0.0e+00 hypothetical protein TcasGA2_TC001512 [Tribolium castaneum] 642938255 XM_008199910.1 478 0 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O35598 1514 6.0e-166 Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus GN=Adam10 PE=1 SV=2 PF01421//PF11857//PF01562 Reprolysin (M12B) family zinc metalloprotease//Domain of unknown function (DUF3377)//Reprolysin family propeptide GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.40698 BP_3 40.28 0.38 5413 546675192 ERL86428.1 1659 1.5e-181 hypothetical protein D910_03835 [Dendroctonus ponderosae] -- -- -- -- -- K17541 SCYL2 SCY1-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17541 Q6P3W7 1116 5.7e-120 SCY1-like protein 2 OS=Homo sapiens GN=SCYL2 PE=1 SV=1 PF00069//PF07776//PF07714//PF00096//PF02985//PF16622//PF13912//PF13465 Protein kinase domain//Zinc-finger associated domain (zf-AD)//Protein tyrosine kinase//Zinc finger, C2H2 type//HEAT repeat//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain GO:0006468 protein phosphorylation GO:0008270//GO:0005524//GO:0004672//GO:0046872//GO:0005515 zinc ion binding//ATP binding//protein kinase activity//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.4070 BP_3 1017.94 18.61 2928 478252248 ENN72676.1 1234 1.5e-132 hypothetical protein YQE_10774, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI17 1151 2.7e-124 Protein yellow OS=Drosophila yakuba GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40700 BP_3 299.41 1.76 8512 642910377 XP_971554.2 7752 0.0e+00 PREDICTED: uncharacterized protein LOC660207 isoform X3 [Tribolium castaneum] 194747504 XM_001956156.1 230 5.40484e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q9CPW0 626 5.9e-63 Contactin-associated protein-like 2 OS=Mus musculus GN=Cntnap2 PE=1 SV=2 PF00008//PF02432//PF10192//PF00014 EGF-like domain//Fimbrial, major and minor subunit//Rhodopsin-like GPCR transmembrane domain//Kunitz/Bovine pancreatic trypsin inhibitor domain GO:0019236//GO:0007186//GO:0007155 response to pheromone//G-protein coupled receptor signaling pathway//cell adhesion GO:0005515//GO:0004867 protein binding//serine-type endopeptidase inhibitor activity GO:0009289 pilus -- -- Cluster-8309.40701 BP_3 10.00 0.63 1057 332374140 AEE62211.1 547 2.6e-53 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09521 NgoPII restriction endonuclease GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.40702 BP_3 4.00 1.53 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40703 BP_3 2826.27 104.61 1594 478252421 ENN72845.1 860 2.0e-89 hypothetical protein YQE_10525, partial [Dendroctonus ponderosae]>gi|546677840|gb|ERL88597.1| hypothetical protein D910_05982 [Dendroctonus ponderosae] 209921946 EU797511.1 126 6.47207e-57 Pinctada fucata calcineurin B subunit mRNA, complete cds K06268 PPP3R, CNB serine/threonine-protein phosphatase 2B regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06268 Q24214 838 2.9e-88 Calcineurin subunit B type 2 OS=Drosophila melanogaster GN=CanB2 PE=1 SV=2 PF00036//PF13202//PF10229//PF13499//PF10591//PF13833//PF13405//PF12763 EF hand//EF hand//Uncharacterized conserved protein (DUF2246)//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand GO:0007165//GO:0009235 signal transduction//cobalamin metabolic process GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.40704 BP_3 50.67 0.47 5442 642927078 XP_008195127.1 1453 1.2e-157 PREDICTED: probable G-protein coupled receptor Mth-like 5 [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VGG8 1038 6.3e-111 Probable G-protein coupled receptor Mth-like 5 OS=Drosophila melanogaster GN=mthl5 PE=2 SV=2 PF00001//PF00002//PF02742 7 transmembrane receptor (rhodopsin family)//7 transmembrane receptor (Secretin family)//Iron dependent repressor, metal binding and dimerisation domain GO:0007186 G-protein coupled receptor signaling pathway GO:0046983//GO:0004930//GO:0046914 protein dimerization activity//G-protein coupled receptor activity//transition metal ion binding GO:0016021 integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.40707 BP_3 317.10 5.19 3236 642931611 XP_971230.2 3113 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase isoform X1 [Tribolium castaneum] 808137240 XR_001099267.1 138 2.83431e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 3.1e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.40708 BP_3 67.70 0.86 4077 642927357 XP_008195235.1 881 1.8e-91 PREDICTED: glutamate receptor ionotropic, kainate 2-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.40710 BP_3 649.40 5.89 5610 91082499 XP_972877.1 1298 1.1e-139 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q7ZU29 712 4.1e-73 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF04097//PF00637//PF06701//PF16276//PF02066//PF04121//PF00569 Nup93/Nic96//Region in Clathrin and VPS//Mib_herc2//Nucleophosmin C-terminal domain//Metallothionein family 11//Nuclear pore protein 84 / 107//Zinc finger, ZZ type GO:0006810//GO:0016192//GO:0016567//GO:0006886 transport//vesicle-mediated transport//protein ubiquitination//intracellular protein transport GO:0005507//GO:0004842//GO:0008270//GO:0003676//GO:0046872 copper ion binding//ubiquitin-protein transferase activity//zinc ion binding//nucleic acid binding//metal ion binding GO:0005643 nuclear pore -- -- Cluster-8309.40712 BP_3 26.45 0.56 2555 675380246 KFM73148.1 252 1.0e-18 hypothetical protein X975_19875, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40713 BP_3 302.44 1.17 12782 642938657 XP_008197674.1 3758 0.0e+00 PREDICTED: probable G-protein coupled receptor 125 [Tribolium castaneum] -- -- -- -- -- K09478 ACADSB short/branched chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09478 P45954 1254 1.3e-135 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1 PF02793//PF01825//PF00441//PF13895//PF13855//PF02770//PF02771//PF00002 Hormone receptor domain//GPCR proteolysis site, GPS, motif//Acyl-CoA dehydrogenase, C-terminal domain//Immunoglobulin domain//Leucine rich repeat//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//7 transmembrane receptor (Secretin family) GO:0008152//GO:0007186//GO:0006118//GO:0055114 metabolic process//G-protein coupled receptor signaling pathway//obsolete electron transport//oxidation-reduction process GO:0004930//GO:0003995//GO:0005515//GO:0050660//GO:0016627 G-protein coupled receptor activity//acyl-CoA dehydrogenase activity//protein binding//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0016020 integral component of membrane//membrane KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.40714 BP_3 511.58 2.25 11252 642938657 XP_008197674.1 3758 0.0e+00 PREDICTED: probable G-protein coupled receptor 125 [Tribolium castaneum] -- -- -- -- -- K09478 ACADSB short/branched chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09478 P45954 1254 1.2e-135 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1 PF02770//PF02771//PF00002//PF13855//PF00441//PF13895//PF02793//PF01825 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//7 transmembrane receptor (Secretin family)//Leucine rich repeat//Acyl-CoA dehydrogenase, C-terminal domain//Immunoglobulin domain//Hormone receptor domain//GPCR proteolysis site, GPS, motif GO:0008152//GO:0007186//GO:0006118//GO:0055114 metabolic process//G-protein coupled receptor signaling pathway//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0004930//GO:0005515//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//G-protein coupled receptor activity//protein binding//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0016020 integral component of membrane//membrane KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.40715 BP_3 72.62 1.41 2772 642916212 XP_008190932.1 3443 0.0e+00 PREDICTED: nuclear pore complex protein Nup205 [Tribolium castaneum]>gi|270004157|gb|EFA00605.1| hypothetical protein TcasGA2_TC003479 [Tribolium castaneum] -- -- -- -- -- K14310 NUP205, NUP192 nuclear pore complex protein Nup205 http://www.genome.jp/dbget-bin/www_bget?ko:K14310 Q92621 1553 6.2e-171 Nuclear pore complex protein Nup205 OS=Homo sapiens GN=NUP205 PE=1 SV=3 PF11894 Nuclear pore complex scaffold, nucleoporins 186/192/205 -- -- -- -- GO:0005643 nuclear pore KOG1835 Uncharacterized conserved protein Cluster-8309.4072 BP_3 4.72 0.78 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40720 BP_3 221.31 0.96 11392 642937913 XP_972695.3 1601 1.7e-174 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.6e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40721 BP_3 172.00 6.16 1637 321451287 EFX62988.1 233 1.0e-16 hypothetical protein DAPPUDRAFT_67487, partial [Daphnia pulex] 56968030 AY859576.1 713 0 Gaetice depressus 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- PF04726 Microvirus J protein -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.40724 BP_3 1630.00 12.70 6477 91089857 XP_971049.1 1232 5.8e-132 PREDICTED: mRNA-decapping enzyme 1B [Tribolium castaneum]>gi|270013572|gb|EFA10020.1| hypothetical protein TcasGA2_TC012192 [Tribolium castaneum] -- -- -- -- -- K12611 DCP1B mRNA-decapping enzyme 1B http://www.genome.jp/dbget-bin/www_bget?ko:K12611 Q8IZD4 345 1.7e-30 mRNA-decapping enzyme 1B OS=Homo sapiens GN=DCP1B PE=1 SV=2 PF01064//PF06058 Activin types I and II receptor domain//Dcp1-like decapping family GO:0016310//GO:0009069//GO:0007178//GO:0000290//GO:0043085 phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway//deadenylation-dependent decapping of nuclear-transcribed mRNA//positive regulation of catalytic activity GO:0004675//GO:0008047 transmembrane receptor protein serine/threonine kinase activity//enzyme activator activity GO:0016020 membrane KOG2868 Decapping enzyme complex component DCP1 Cluster-8309.40726 BP_3 148.39 2.12 3660 66864094 BAD99298.1 1697 4.0e-186 ultraspiracle [Leptinotarsa decemlineata] 662618236 AB506667.1 134 5.37122e-61 Harmonia axyridis HaUSP-1 mRNA for ultraspiracle 1 isoform, complete cds K14030 NR2B4, usp nuclear receptor subfamily 2 group B member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14030 Q5I7G2 1198 1.2e-129 Retinoic acid receptor RXR OS=Lymnaea stagnalis GN=RXR PE=1 SV=1 PF00105//PF00104//PF08997 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor//Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0006118//GO:0006355//GO:0043401//GO:0015992//GO:0006119 obsolete electron transport//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//proton transport//oxidative phosphorylation GO:0008270//GO:0009055//GO:0043565//GO:0003700//GO:0008121 zinc ion binding//electron carrier activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//ubiquinol-cytochrome-c reductase activity GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.40727 BP_3 120.93 1.74 3642 66864094 BAD99298.1 1697 3.9e-186 ultraspiracle [Leptinotarsa decemlineata] 662618236 AB506667.1 134 5.34455e-61 Harmonia axyridis HaUSP-1 mRNA for ultraspiracle 1 isoform, complete cds K14030 NR2B4, usp nuclear receptor subfamily 2 group B member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14030 Q5I7G2 1198 1.2e-129 Retinoic acid receptor RXR OS=Lymnaea stagnalis GN=RXR PE=1 SV=1 PF08997//PF00104//PF00105 Ubiquinol-cytochrome C reductase complex, 6.4kD protein//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006119//GO:0015992//GO:0006118//GO:0006355//GO:0043401 oxidative phosphorylation//proton transport//obsolete electron transport//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008121//GO:0003700//GO:0008270//GO:0009055//GO:0043565 ubiquinol-cytochrome-c reductase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//electron carrier activity//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.40729 BP_3 114.30 0.93 6192 642923453 XP_008193751.1 2402 1.2e-267 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1046 8.5e-112 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF07569//PF02460//PF00400 TUP1-like enhancer of split//Patched family//WD domain, G-beta repeat GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0008158//GO:0005515 hedgehog receptor activity//protein binding GO:0005634//GO:0016020 nucleus//membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.4073 BP_3 38.74 0.54 3740 189237510 XP_972627.2 847 1.5e-87 PREDICTED: uncharacterized protein LOC661374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P90666 274 1.7e-22 Thioredoxin domain-containing protein 3 homolog OS=Heliocidaris crassispina GN=NME8 PE=1 SV=1 PF04198//PF06213//PF02694//PF02535//PF04501//PF00085//PF06390//PF01080//PF01517//PF04147//PF04931 Putative sugar-binding domain//Cobalamin biosynthesis protein CobT//Uncharacterised BCR, YnfA/UPF0060 family//ZIP Zinc transporter//Baculovirus major capsid protein VP39//Thioredoxin//Neuroendocrine-specific golgi protein P55 (NESP55)//Presenilin//Hepatitis delta virus delta antigen//Nop14-like family//DNA polymerase phi GO:0006351//GO:0030001//GO:0071107//GO:0045454//GO:0055085//GO:0009236//GO:0006260 transcription, DNA-templated//metal ion transport//response to parathyroid hormone//cell redox homeostasis//transmembrane transport//cobalamin biosynthetic process//DNA replication GO:0003887//GO:0003723//GO:0004190//GO:0003677//GO:0046873//GO:0005198//GO:0030246 DNA-directed DNA polymerase activity//RNA binding//aspartic-type endopeptidase activity//DNA binding//metal ion transmembrane transporter activity//structural molecule activity//carbohydrate binding GO:0016020//GO:0042575//GO:0019028//GO:0016021//GO:0042025//GO:0032040 membrane//DNA polymerase complex//viral capsid//integral component of membrane//host cell nucleus//small-subunit processome -- -- Cluster-8309.40731 BP_3 670.53 4.31 7798 642924396 XP_008194278.1 1678 1.3e-183 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] 706147644 XM_010207329.1 63 3.38337e-21 PREDICTED: Colius striatus family with sequence similarity 76, member B (FAM76B), partial mRNA -- -- -- -- Q5ZJ65 773 4.8e-80 Protein FAM76A OS=Gallus gallus GN=FAM76A PE=2 SV=1 PF07714//PF08656//PF00069//PF00541//PF00170//PF03852//PF01920//PF00227//PF03938//PF04728//PF04513//PF01025//PF00416 Protein tyrosine kinase//DASH complex subunit Dad3//Protein kinase domain//Adenoviral fibre protein (knob domain)//bZIP transcription factor//DNA mismatch endonuclease Vsr//Prefoldin subunit//Proteasome subunit//Outer membrane protein (OmpH-like)//Lipoprotein leucine-zipper//Baculovirus polyhedron envelope protein, PEP, C terminus//GrpE//Ribosomal protein S13/S18 GO:0042254//GO:0008608//GO:0006298//GO:0051603//GO:0006468//GO:0006355//GO:0006412//GO:0006457//GO:0019062 ribosome biogenesis//attachment of spindle microtubules to kinetochore//mismatch repair//proteolysis involved in cellular protein catabolic process//protein phosphorylation//regulation of transcription, DNA-templated//translation//protein folding//virion attachment to host cell GO:0005524//GO:0003700//GO:0051082//GO:0051087//GO:0003735//GO:0004519//GO:0004672//GO:0005198//GO:0000774//GO:0043565//GO:0003723//GO:0004298//GO:0042803 ATP binding//transcription factor activity, sequence-specific DNA binding//unfolded protein binding//chaperone binding//structural constituent of ribosome//endonuclease activity//protein kinase activity//structural molecule activity//adenyl-nucleotide exchange factor activity//sequence-specific DNA binding//RNA binding//threonine-type endopeptidase activity//protein homodimerization activity GO:0019028//GO:0016272//GO:0005667//GO:0072686//GO:0005839//GO:0005622//GO:0005840//GO:0042729//GO:0019031//GO:0019867 viral capsid//prefoldin complex//transcription factor complex//mitotic spindle//proteasome core complex//intracellular//ribosome//DASH complex//viral envelope//outer membrane KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.40733 BP_3 474.44 3.92 6132 546670634 ERL83320.1 5497 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.49373e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q8NFA0 1141 8.1e-123 Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens GN=USP32 PE=1 SV=1 PF05191//PF00036//PF13405//PF06337//PF13499//PF00443//PF11421 Adenylate kinase, active site lid//EF hand//EF-hand domain//DUSP domain//EF-hand domain pair//Ubiquitin carboxyl-terminal hydrolase//ATP synthase F1 beta subunit GO:0046034//GO:0006144//GO:0006508//GO:0016579//GO:0006754 ATP metabolic process//purine nucleobase metabolic process//proteolysis//protein deubiquitination//ATP biosynthetic process GO:0004843//GO:0005524//GO:0036459//GO:0016887//GO:0005509//GO:0004017 ubiquitin-specific protease activity//ATP binding//ubiquitinyl hydrolase activity//ATPase activity//calcium ion binding//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.40734 BP_3 117.44 1.82 3401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.40735 BP_3 41.00 24.31 370 642924223 XP_008194205.1 353 2.8e-31 PREDICTED: endocuticle structural glycoprotein SgAbd-8-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 246 2.9e-20 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.40736 BP_3 31699.90 217.30 7323 157136306 XP_001656823.1 2693 2.5e-301 AAEL003419-PA [Aedes aegypti]>gi|108881091|gb|EAT45316.1| AAEL003419-PA [Aedes aegypti] 332374193 BT127276.1 730 0 Dendroctonus ponderosae clone DPO011_E07 unknown mRNA -- -- -- -- P61023 569 2.1e-56 Calcineurin B homologous protein 1 OS=Rattus norvegicus GN=Chp1 PE=1 SV=2 PF12763//PF01522//PF13499//PF00963//PF13833//PF10591//PF13405//PF01708//PF13202//PF00036 Cytoskeletal-regulatory complex EF hand//Polysaccharide deacetylase//EF-hand domain pair//Cohesin domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Geminivirus putative movement protein//EF hand//EF hand GO:0007165//GO:0006030//GO:0000272//GO:0006807//GO:0005975//GO:0046740 signal transduction//chitin metabolic process//polysaccharide catabolic process//nitrogen compound metabolic process//carbohydrate metabolic process//transport of virus in host, cell to cell GO:0005515//GO:0005509//GO:0030246//GO:0016810//GO:0008061 protein binding//calcium ion binding//carbohydrate binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0016021//GO:0005576//GO:0005578 integral component of membrane//extracellular region//proteinaceous extracellular matrix KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.40738 BP_3 832.31 9.96 4320 642922624 XP_008193254.1 3710 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] 642922625 XM_008195033.1 226 4.57316e-112 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4074 BP_3 31.01 0.39 4128 189237510 XP_972627.2 974 3.1e-102 PREDICTED: uncharacterized protein LOC661374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P90666 274 1.9e-22 Thioredoxin domain-containing protein 3 homolog OS=Heliocidaris crassispina GN=NME8 PE=1 SV=1 PF00085//PF03286//PF03153 Thioredoxin//Pox virus Ag35 surface protein//Transcription factor IIA, alpha/beta subunit GO:0045454//GO:0006367 cell redox homeostasis//transcription initiation from RNA polymerase II promoter -- -- GO:0005672//GO:0019031 transcription factor TFIIA complex//viral envelope -- -- Cluster-8309.40741 BP_3 98.63 3.57 1623 270011231 EFA07679.1 1076 1.8e-114 hypothetical protein TcasGA2_TC030712 [Tribolium castaneum] -- -- -- -- -- K14026 SEL1, SEL1L SEL1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14026 Q80Z70 530 1.5e-52 Protein sel-1 homolog 1 OS=Rattus norvegicus GN=Sel1l PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1550 Extracellular protein SEL-1 and related proteins Cluster-8309.40742 BP_3 27.00 1.15 1421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219//PF00093 Insulin-like growth factor binding protein//von Willebrand factor type C domain GO:0001558 regulation of cell growth GO:0005520//GO:0005515 insulin-like growth factor binding//protein binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-8309.40744 BP_3 116.41 1.16 5129 478258615 ENN78665.1 281 8.7e-22 hypothetical protein YQE_04837, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08720 Influenza C hemagglutinin stalk GO:0019064//GO:0007165 fusion of virus membrane with host plasma membrane//signal transduction GO:0046789 host cell surface receptor binding GO:0019031//GO:0009986 viral envelope//cell surface -- -- Cluster-8309.40750 BP_3 4260.52 83.33 2756 665810054 XP_008553427.1 1656 1.7e-181 PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|665810056|ref|XP_008553428.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|751201535|ref|XP_011167836.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Solenopsis invicta]>gi|780681748|ref|XP_011697692.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Wasmannia auropunctata]>gi|795064613|ref|XP_011874023.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Vollenhovia emeryi]>gi|826425920|ref|XP_012527326.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Monomorium pharaonis] 642933469 XM_968453.3 436 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (LOC662352), mRNA K04382 PPP2C serine/threonine-protein phosphatase 2A catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04382 P62716 1626 2.1e-179 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2cb PE=2 SV=1 PF02135//PF00149 TAZ zinc finger//Calcineurin-like phosphoesterase GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0003712//GO:0008270//GO:0004402//GO:0016787 transcription cofactor activity//zinc ion binding//histone acetyltransferase activity//hydrolase activity GO:0000123//GO:0005667//GO:0005634 histone acetyltransferase complex//transcription factor complex//nucleus KOG0371 Serine/threonine protein phosphatase 2A, catalytic subunit Cluster-8309.40751 BP_3 47.54 0.50 4894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40752 BP_3 405.07 7.92 2756 282158103 NP_001164095.1 1630 1.8e-178 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] 195492386 XM_002093932.1 172 3.0295e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1338 5.2e-146 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0016787//GO:0003677//GO:0003676//GO:0005524 hydrolase activity//DNA binding//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.40753 BP_3 1661.55 24.55 3554 478252006 ENN72441.1 2821 0.0e+00 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1423 9.4e-156 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF05173//PF01433 Dihydrodipicolinate reductase, C-terminus//Peptidase family M1 GO:0009089//GO:0055114//GO:0009085 lysine biosynthetic process via diaminopimelate//oxidation-reduction process//lysine biosynthetic process GO:0008270//GO:0008839//GO:0008237 zinc ion binding//4-hydroxy-tetrahydrodipicolinate reductase//metallopeptidase activity -- -- -- -- Cluster-8309.40754 BP_3 42.14 1.33 1822 270008882 EFA05330.1 382 6.0e-34 hypothetical protein TcasGA2_TC015494 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01842 134 1.4e-06 Ets DNA-binding protein pokkuri OS=Drosophila melanogaster GN=aop PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.40756 BP_3 16.27 0.49 1901 546684751 ERL94361.1 1098 5.9e-117 hypothetical protein D910_11641 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4MYA4 525 6.7e-52 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083//PF02086 Major Facilitator Superfamily//Sugar (and other) transporter//D12 class N6 adenine-specific DNA methyltransferase GO:0055085//GO:0032775//GO:0006306 transmembrane transport//DNA methylation on adenine//DNA methylation GO:0022857//GO:0009007 transmembrane transporter activity//site-specific DNA-methyltransferase (adenine-specific) activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.40757 BP_3 220.00 5.62 2180 546675819 ERL86931.1 746 4.4e-76 hypothetical protein D910_04334, partial [Dendroctonus ponderosae] -- -- -- -- -- K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11147 577 7.2e-58 Heat shock 70 kDa protein cognate 4 OS=Drosophila melanogaster GN=Hsc70-4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.40758 BP_3 1233.75 18.34 3535 646712387 KDR17169.1 1960 1.2e-216 Extracellular sulfatase SULF-1-like protein, partial [Zootermopsis nevadensis] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.5e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- KOG3731 Sulfatases Cluster-8309.40759 BP_3 21.73 0.59 2081 642913237 XP_008201451.1 549 3.0e-53 PREDICTED: zinc finger protein 830 [Tribolium castaneum] 828206332 XM_012701468.1 44 3.25575e-11 PREDICTED: Hydra vulgaris zinc finger protein 830-like (LOC100205964), mRNA K13104 ZNF830, CCDC16 zinc finger protein 830 http://www.genome.jp/dbget-bin/www_bget?ko:K13104 Q6DJ13 208 4.2e-15 Zinc finger protein 830 OS=Xenopus tropicalis GN=znf830 PE=2 SV=1 PF16525//PF15898//PF00484 Haemophore, haem-binding//cGMP-dependent protein kinase interacting domain//Carbonic anhydrase GO:0006807//GO:0006730 nitrogen compound metabolic process//one-carbon metabolic process GO:0020037//GO:0004089//GO:0008270//GO:0019901 heme binding//carbonate dehydratase activity//zinc ion binding//protein kinase binding -- -- KOG3032 Uncharacterized conserved protein Cluster-8309.40761 BP_3 383.39 2.50 7671 478260669 ENN80366.1 2509 5.8e-280 hypothetical protein YQE_03225, partial [Dendroctonus ponderosae] 698430595 XM_009698856.1 46 9.38494e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K08734 MLH1 DNA mismatch repair protein MLH1 http://www.genome.jp/dbget-bin/www_bget?ko:K08734 P40692 1843 4.0e-204 DNA mismatch repair protein Mlh1 OS=Homo sapiens GN=MLH1 PE=1 SV=1 PF12422//PF01119//PF00443//PF05427 Condensin II non structural maintenance of chromosomes subunit//DNA mismatch repair protein, C-terminal domain//Ubiquitin carboxyl-terminal hydrolase//Acidic fibroblast growth factor binding (FIBP) GO:0006298//GO:0016579 mismatch repair//protein deubiquitination GO:0036459//GO:0005524//GO:0017134//GO:0030983 ubiquitinyl hydrolase activity//ATP binding//fibroblast growth factor binding//mismatched DNA binding GO:0005634 nucleus KOG1979 DNA mismatch repair protein - MLH1 family Cluster-8309.40762 BP_3 546.60 13.43 2254 642931533 XP_008196625.1 1634 4.9e-179 PREDICTED: WW domain-containing oxidoreductase [Tribolium castaneum] -- -- -- -- -- K19329 WWOX WW domain-containing oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K19329 Q9VLU5 1171 9.9e-127 WW domain-containing oxidoreductase OS=Drosophila melanogaster GN=Wwox PE=2 SV=1 PF00106//PF00397//PF02826 short chain dehydrogenase//WW domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0005515//GO:0016491//GO:0051287 protein binding//oxidoreductase activity//NAD binding -- -- -- -- Cluster-8309.40763 BP_3 105.61 9.32 838 546682146 ERL92127.1 813 2.9e-84 hypothetical protein D910_09447 [Dendroctonus ponderosae] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 P59510 468 1.2e-45 A disintegrin and metalloproteinase with thrombospondin motifs 20 OS=Homo sapiens GN=ADAMTS20 PE=2 SV=2 PF05986 ADAM-TS Spacer 1 -- -- GO:0004222 metalloendopeptidase activity GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.40764 BP_3 3.00 23.41 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40766 BP_3 1.76 0.33 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40767 BP_3 990.19 3.83 12754 91083299 XP_974608.1 2229 2.8e-247 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 3.1e-193 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 PF01695//PF06414//PF00004//PF11057//PF06309 IstB-like ATP binding protein//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Cortexin of kidney//Torsin -- -- GO:0005524//GO:0016301 ATP binding//kinase activity GO:0031224 intrinsic component of membrane KOG2558 Negative regulator of histones Cluster-8309.40768 BP_3 586.69 5.72 5234 817182178 XP_012288780.1 1873 2.2e-206 PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182180|ref|XP_012288789.1| PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182182|ref|XP_012288795.1| PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182184|ref|XP_012288803.1| PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182186|ref|XP_012288810.1| PREDICTED: zinc transporter 9 [Orussus abietinus] -- -- -- -- -- K14696 SLC30A9, ZNT9 solute carrier family 30 (zinc transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14696 Q5PQZ3 1323 5.4e-144 Zinc transporter 9 OS=Danio rerio GN=slc30a9 PE=2 SV=1 PF01545//PF00707 Cation efflux family//Translation initiation factor IF-3, C-terminal domain GO:0006812//GO:0055085//GO:0006413 cation transport//transmembrane transport//translational initiation GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG2802 Membrane protein HUEL (cation efflux superfamily) Cluster-8309.40769 BP_3 146.36 0.56 12797 91083299 XP_974608.1 2229 2.8e-247 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 3.1e-193 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 PF11057//PF06309//PF00004//PF06414//PF01695 Cortexin of kidney//Torsin//ATPase family associated with various cellular activities (AAA)//Zeta toxin//IstB-like ATP binding protein -- -- GO:0016301//GO:0005524 kinase activity//ATP binding GO:0031224 intrinsic component of membrane KOG2558 Negative regulator of histones Cluster-8309.40771 BP_3 119.16 1.28 4775 668448107 KFB37812.1 1866 1.3e-205 AGAP012046-PA-like protein [Anopheles sinensis] -- -- -- -- -- K14696 SLC30A9, ZNT9 solute carrier family 30 (zinc transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14696 Q5PQZ3 1323 5.0e-144 Zinc transporter 9 OS=Danio rerio GN=slc30a9 PE=2 SV=1 PF00707//PF01545 Translation initiation factor IF-3, C-terminal domain//Cation efflux family GO:0006812//GO:0006413//GO:0055085 cation transport//translational initiation//transmembrane transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG2802 Membrane protein HUEL (cation efflux superfamily) Cluster-8309.40772 BP_3 2205.04 10.27 10643 642937913 XP_972695.3 1638 8.0e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.5e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40773 BP_3 318.73 2.87 5640 642916006 XP_008190854.1 2755 1.3e-308 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40774 BP_3 20.04 0.96 1296 189239365 XP_970191.2 1011 4.9e-107 PREDICTED: probable chitinase 2 [Tribolium castaneum]>gi|270010475|gb|EFA06923.1| hypothetical protein TcasGA2_TC009872 [Tribolium castaneum] 827562517 XM_004933295.2 39 1.20766e-08 PREDICTED: Bombyx mori probable chitinase 2 (LOC101744821), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W092 656 3.0e-67 Probable chitinase 2 OS=Drosophila melanogaster GN=Cht2 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0071704//GO:0005975 organic substance metabolic process//carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.40775 BP_3 49.28 2.01 1476 91083175 XP_972331.1 437 2.0e-40 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 321 2.4e-28 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 PF15182 Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.40777 BP_3 1412.16 12.93 5554 270013772 EFA10220.1 5461 0.0e+00 hypothetical protein TcasGA2_TC012416 [Tribolium castaneum] 158287295 XM_309356.4 147 4.85296e-68 Anopheles gambiae str. PEST AGAP011292-PA (AgaP_AGAP011292) mRNA, complete cds -- -- -- -- Q24020 4278 0.0e+00 Protein flightless-1 OS=Drosophila melanogaster GN=fliI PE=2 SV=1 PF13855//PF00560//PF08661 Leucine rich repeat//Leucine Rich Repeat//Replication factor A protein 3 GO:0006260//GO:0006310//GO:0006281 DNA replication//DNA recombination//DNA repair GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG0444 Cytoskeletal regulator Flightless-I (contains leucine-rich and gelsolin repeats) Cluster-8309.40780 BP_3 46.50 1.80 1535 642922284 XP_008193093.1 1153 2.0e-123 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 706 5.6e-73 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- KOG3731 Sulfatases Cluster-8309.40781 BP_3 83.73 1.85 2471 194473697 NP_001123993.1 1360 3.2e-147 cytochrome P450 CYP4BN1 [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 921 1.1e-97 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.40782 BP_3 110.05 1.26 4499 478260090 ENN79875.1 2429 6.4e-271 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 7.09964e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 1997 3.3e-222 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006094//GO:0006000//GO:0006013//GO:0006012//GO:0006098//GO:0006096 gluconeogenesis//fructose metabolic process//mannose metabolic process//galactose metabolic process//pentose-phosphate shunt//glycolytic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.40784 BP_3 49.00 1.15 2341 -- -- -- -- -- 462381300 APGK01022056.1 51 4.71332e-15 Dendroctonus ponderosae Seq01022066, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40786 BP_3 1037.29 6.90 7540 91090366 XP_968305.1 1722 1.0e-188 PREDICTED: T-cell immunomodulatory protein [Tribolium castaneum]>gi|270013408|gb|EFA09856.1| hypothetical protein TcasGA2_TC012004 [Tribolium castaneum] 765338960 XM_011495191.1 147 6.59665e-68 Aedes aegypti AAEL017098-RA partial mRNA K17257 ITFG1 integrin alpha FG-GAP repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17257 P18459 1010 1.5e-107 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00140//PF00351 Sigma-70 factor, region 1.2//Biopterin-dependent aromatic amino acid hydroxylase GO:0006355//GO:0055114//GO:0006352 regulation of transcription, DNA-templated//oxidation-reduction process//DNA-templated transcription, initiation GO:0016987//GO:0003700//GO:0003677//GO:0016714 sigma factor activity//transcription factor activity, sequence-specific DNA binding//DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0005667 transcription factor complex KOG3820 Aromatic amino acid hydroxylase Cluster-8309.40787 BP_3 1382.64 39.13 1995 256862217 ACU77882.2 1438 2.3e-156 tyrosine hydroxylase [Tenebrio molitor] 765338960 XM_011495191.1 199 2.13785e-97 Aedes aegypti AAEL017098-RA partial mRNA K00501 TH tyrosine 3-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00501 P18459 1241 6.7e-135 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00351 Biopterin-dependent aromatic amino acid hydroxylase GO:0055114 oxidation-reduction process GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.40789 BP_3 312.20 15.07 1290 189236107 XP_973934.2 817 1.5e-84 PREDICTED: high mobility group protein DSP1-like [Tribolium castaneum] 642918928 XM_968841.3 235 1.33068e-117 PREDICTED: Tribolium castaneum high mobility group protein DSP1-like (LOC662763), mRNA K10802 HMGB1 high mobility group protein B1 http://www.genome.jp/dbget-bin/www_bget?ko:K10802 Q24537 690 3.4e-71 High mobility group protein DSP1 OS=Drosophila melanogaster GN=Dsp1 PE=2 SV=1 PF09606//PF04961//PF15761 ARC105 or Med15 subunit of Mediator complex non-fungal//Formiminotransferase-cyclodeaminase//Immortalisation up-regulated protein GO:0006357//GO:0044237 regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0001104//GO:0003824 RNA polymerase II transcription cofactor activity//catalytic activity GO:0016592//GO:0005634 mediator complex//nucleus KOG0381 HMG box-containing protein Cluster-8309.40792 BP_3 74.42 2.00 2089 642936925 XP_008194485.1 875 4.7e-91 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X2 [Tribolium castaneum] -- -- -- -- -- K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 264 1.4e-21 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF13606//PF00023//PF09494 Ankyrin repeat//Ankyrin repeat//Slx4 endonuclease GO:0006281//GO:0006308//GO:0006260 DNA repair//DNA catabolic process//DNA replication GO:0005515//GO:0017108 protein binding//5'-flap endonuclease activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus -- -- Cluster-8309.40795 BP_3 172.00 5.04 1938 741829513 AJA91072.1 1000 1.4e-105 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 696 1.0e-71 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.40796 BP_3 40.61 0.71 3043 189242457 XP_970217.2 215 2.3e-14 PREDICTED: neuroglian isoform X2 [Tribolium castaneum]>gi|642939198|ref|XP_008200377.1| PREDICTED: neuroglian isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20241 184 3.8e-12 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF02979//PF05864 Nitrile hydratase, alpha chain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) GO:0006206//GO:0006807//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003824//GO:0046914//GO:0003899 DNA binding//catalytic activity//transition metal ion binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.40797 BP_3 6.00 3.29 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08094 Conotoxin TVIIA/GS family GO:0006810//GO:0009405 transport//pathogenesis GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.40798 BP_3 131.19 4.62 1660 642930262 XP_971408.3 1014 2.8e-107 PREDICTED: transmembrane protein 192 [Tribolium castaneum]>gi|270009437|gb|EFA05885.1| hypothetical protein TcasGA2_TC008697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NYE7 225 3.6e-17 Transmembrane protein 192 OS=Danio rerio GN=tmem192 PE=2 SV=1 PF04736 Eclosion hormone GO:0018990//GO:0007218 ecdysis, chitin-based cuticle//neuropeptide signaling pathway GO:0008255 ecdysis-triggering hormone activity -- -- -- -- Cluster-8309.40800 BP_3 3.00 0.40 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40802 BP_3 187.43 5.89 1826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40804 BP_3 2363.20 35.29 3519 478257295 ENN77458.1 3420 0.0e+00 hypothetical protein YQE_06282, partial [Dendroctonus ponderosae] 572316028 XM_006623585.1 146 1.10173e-67 PREDICTED: Apis dorsata uncharacterized LOC102670726 (LOC102670726), transcript variant X2, mRNA -- -- -- -- P48053 1295 6.4e-141 Uncharacterized protein C05D11.1 OS=Caenorhabditis elegans GN=C05D11.1 PE=4 SV=2 PF08367//PF04987 Peptidase M16C associated//Phosphatidylinositolglycan class N (PIG-N) GO:0006506//GO:0006508 GPI anchor biosynthetic process//proteolysis GO:0016740 transferase activity GO:0005789 endoplasmic reticulum membrane KOG2019 Metalloendoprotease HMP1 (insulinase superfamily) Cluster-8309.40805 BP_3 691.47 15.17 2489 642928324 XP_008195534.1 3092 0.0e+00 PREDICTED: exocyst complex component 5 [Tribolium castaneum]>gi|270009802|gb|EFA06250.1| hypothetical protein TcasGA2_TC009108 [Tribolium castaneum] 826409849 XM_012679854.1 54 1.07808e-16 PREDICTED: Monomorium pharaonis exocyst complex component 5 (LOC105836070), mRNA -- -- -- -- Q9XTM1 1915 5.8e-213 Exocyst complex component 5 OS=Drosophila melanogaster GN=sec10 PE=2 SV=1 PF07393 Exocyst complex component Sec10 GO:0048278//GO:0006887 vesicle docking//exocytosis -- -- GO:0005737 cytoplasm KOG3745 Exocyst subunit - Sec10p Cluster-8309.40807 BP_3 2450.00 30.12 4212 820805522 AKG92752.1 837 2.4e-86 diminutive [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q17103 217 7.7e-16 Myc protein (Fragment) OS=Asterias rubens GN=MYC PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.4081 BP_3 13.67 0.66 1283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00165 Bacterial regulatory helix-turn-helix proteins, AraC family GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.40810 BP_3 199.00 18.58 808 642910507 XP_008200244.1 142 1.8e-06 PREDICTED: uncharacterized protein LOC660017 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40815 BP_3 707.08 18.69 2115 332026895 EGI66996.1 1641 7.1e-180 Heterogeneous nuclear ribonucleoprotein Q [Acromyrmex echinatior] 642914994 XM_008192253.1 391 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X5, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 Q7TMK9 769 3.8e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 PF16367//PF00076//PF11411//PF00023//PF16622 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//DNA ligase IV//Ankyrin repeat//zinc-finger C2H2-type GO:0006260//GO:0006281 DNA replication//DNA repair GO:0003676//GO:0005515//GO:0003910//GO:0046872 nucleic acid binding//protein binding//DNA ligase (ATP) activity//metal ion binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.40817 BP_3 307.34 10.36 1721 642918464 XP_008191487.1 942 6.6e-99 PREDICTED: FK506-binding protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09577 FKBP14 FK506-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09577 Q54SR7 402 1.1e-37 FK506-binding protein 2 OS=Dictyostelium discoideum GN=fkbp2 PE=3 SV=1 PF10591//PF13833//PF00036//PF13405//PF13499//PF00254//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//FKBP-type peptidyl-prolyl cis-trans isomerase//EF hand GO:0007165//GO:0006457 signal transduction//protein folding GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0549 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.40818 BP_3 272.61 3.31 4256 478253821 ENN74113.1 4449 0.0e+00 hypothetical protein YQE_09086, partial [Dendroctonus ponderosae]>gi|546684626|gb|ERL94243.1| hypothetical protein D910_11524 [Dendroctonus ponderosae] 817219709 XM_012430138.1 107 6.38873e-46 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 3303 0.0e+00 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF16656//PF01618//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//MotA/TolQ/ExbB proton channel family//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0006810//GO:0006771//GO:0015031 hexachlorocyclohexane metabolic process//transport//riboflavin metabolic process//protein transport GO:0005515//GO:0008565//GO:0003993//GO:0046872 protein binding//protein transporter activity//acid phosphatase activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.40819 BP_3 2221.38 15.78 7078 91092128 XP_972649.1 4445 0.0e+00 PREDICTED: splicing factor 3B subunit 3 isoform X1 [Tribolium castaneum]>gi|270004662|gb|EFA01110.1| hypothetical protein TcasGA2_TC010322 [Tribolium castaneum] 77623052 CT030548.1 392 0 Xenopus tropicalis finished cDNA, clone TGas034j22 K12830 SF3B3, SAP130, RSE1 splicing factor 3B subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12830 Q15393 3985 0.0e+00 Splicing factor 3B subunit 3 OS=Homo sapiens GN=SF3B3 PE=1 SV=4 PF13414//PF03178//PF02402 TPR repeat//CPSF A subunit region//Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0005634//GO:0019867 nucleus//outer membrane KOG1898 Splicing factor 3b, subunit 3 Cluster-8309.40820 BP_3 393.22 2.54 7759 91092128 XP_972649.1 5382 0.0e+00 PREDICTED: splicing factor 3B subunit 3 isoform X1 [Tribolium castaneum]>gi|270004662|gb|EFA01110.1| hypothetical protein TcasGA2_TC010322 [Tribolium castaneum] 77623052 CT030548.1 392 0 Xenopus tropicalis finished cDNA, clone TGas034j22 K12830 SF3B3, SAP130, RSE1 splicing factor 3B subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12830 A0JN52 4781 0.0e+00 Splicing factor 3B subunit 3 OS=Bos taurus GN=SF3B3 PE=2 SV=1 PF03178 CPSF A subunit region -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG1898 Splicing factor 3b, subunit 3 Cluster-8309.40821 BP_3 1781.54 22.53 4103 642922013 XP_008192985.1 2785 0.0e+00 PREDICTED: argonaute-2b isoform X1 [Tribolium castaneum] -- -- -- -- -- K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 1392 4.3e-152 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF02170//PF02171 PAZ domain//Piwi domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.40822 BP_3 242.86 1.70 7168 642912301 XP_968800.3 1228 1.9e-131 PREDICTED: protein couch potato isoform X2 [Tribolium castaneum] 642912300 XM_963707.3 407 0 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X2, mRNA -- -- -- -- Q01617 796 9.6e-83 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00168//PF00076 C2 domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.40825 BP_3 432.12 3.91 5616 642913783 XP_008201159.1 1313 2.0e-141 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 1.86782e-27 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 1200 1.1e-129 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF03611//PF01562 PTS system sugar-specific permease component//Reprolysin family propeptide GO:0006508//GO:0009401 proteolysis//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.40827 BP_3 28.73 0.39 3866 91079945 XP_968596.1 3239 0.0e+00 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003256|gb|EEZ99703.1| hypothetical protein TcasGA2_TC002464 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 2090 4.6e-233 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF09261//PF01074//PF07748 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0004559//GO:0015923//GO:0008270//GO:0004553//GO:0043169 alpha-mannosidase activity//mannosidase activity//zinc ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.40829 BP_3 2186.33 34.73 3326 189237751 XP_001812575.1 2171 3.9e-241 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 4.9e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF00787//PF00316 PX domain//Fructose-1-6-bisphosphatase GO:0006094//GO:0015976//GO:0005975//GO:0006000//GO:0006013//GO:0006096//GO:0006098 gluconeogenesis//carbon utilization//carbohydrate metabolic process//fructose metabolic process//mannose metabolic process//glycolytic process//pentose-phosphate shunt GO:0042578//GO:0042132//GO:0035091 phosphoric ester hydrolase activity//fructose 1,6-bisphosphate 1-phosphatase activity//phosphatidylinositol binding -- -- KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.40830 BP_3 46.44 0.83 2986 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02948 Amelogenin GO:0007275 multicellular organismal development -- -- GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.40831 BP_3 141.15 0.64 10929 642926973 XP_008195085.1 2249 1.2e-249 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 1.2e-76 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF10186//PF08031//PF02948//PF06206//PF00621//PF05791//PF03650 Vacuolar sorting 38 and autophagy-related subunit 14//Berberine and berberine like//Amelogenin//CpeT/CpcT family (DUF1001)//RhoGEF domain//Bacillus haemolytic enterotoxin (HBL)//Uncharacterised protein family (UPF0041) GO:0010508//GO:0017009//GO:0055114//GO:0043087//GO:0006850//GO:0009405//GO:0007275//GO:0035023 positive regulation of autophagy//protein-phycocyanobilin linkage//oxidation-reduction process//regulation of GTPase activity//mitochondrial pyruvate transport//pathogenesis//multicellular organismal development//regulation of Rho protein signal transduction GO:0005089//GO:0050660//GO:0016491 Rho guanyl-nucleotide exchange factor activity//flavin adenine dinucleotide binding//oxidoreductase activity GO:0005578//GO:0016020//GO:0005743 proteinaceous extracellular matrix//membrane//mitochondrial inner membrane -- -- Cluster-8309.40832 BP_3 15.42 0.40 2130 642917916 XP_008191381.1 712 3.8e-72 PREDICTED: methyltransferase-like protein 17, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U2U7 296 2.7e-25 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF02285//PF12326//PF09243 Cytochrome oxidase c subunit VIII//N-glycosylation protein//Mitochondrial small ribosomal subunit Rsm22 GO:0015992//GO:0034599//GO:0006412//GO:0006123 proton transport//cellular response to oxidative stress//translation//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277//GO:0005789 respiratory chain complex IV//endoplasmic reticulum membrane KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.40833 BP_3 552.02 11.83 2540 859132804 AKO63317.1 1918 6.5e-212 3-hydroxy-3-methylglutaryl coenzyme A synthase [Leptinotarsa decemlineata] -- -- -- -- -- K01641 E2.3.3.10 hydroxymethylglutaryl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01641 P54961 1642 2.7e-181 Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella germanica GN=HMGCS-1 PE=2 SV=1 PF01154//PF08540 Hydroxymethylglutaryl-coenzyme A synthase N terminal//Hydroxymethylglutaryl-coenzyme A synthase C terminal GO:0006574//GO:0006550//GO:0046950//GO:0006084//GO:0006552//GO:0008299 valine catabolic process//isoleucine catabolic process//cellular ketone body metabolic process//acetyl-CoA metabolic process//leucine catabolic process//isoprenoid biosynthetic process GO:0004421 hydroxymethylglutaryl-CoA synthase activity -- -- KOG1393 Hydroxymethylglutaryl-CoA synthase Cluster-8309.40836 BP_3 17.52 0.40 2427 642919248 XP_008191793.1 163 2.0e-08 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|642919250|ref|XP_008191794.1| PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|270005765|gb|EFA02213.1| hypothetical protein TcasGA2_TC007872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0044765 single-organism transport -- -- -- -- -- -- Cluster-8309.40837 BP_3 54.20 1.23 2418 91080555 XP_967130.1 424 1.1e-38 PREDICTED: clathrin light chain isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IY45 297 2.3e-25 Protein AMN1 homolog OS=Homo sapiens GN=AMN1 PE=2 SV=4 PF01086//PF13855 Clathrin light chain//Leucine rich repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle -- -- Cluster-8309.40838 BP_3 1558.96 6.76 11414 642935532 XP_008198047.1 1716 7.7e-188 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Tribolium castaneum]>gi|270013328|gb|EFA09776.1| hypothetical protein TcasGA2_TC011918 [Tribolium castaneum] 755889203 XM_005188558.2 102 1.03628e-42 PREDICTED: Musca domestica vesicular integral-membrane protein VIP36 (LOC101894935), mRNA K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q7L273 1027 2.5e-109 BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens GN=KCTD9 PE=1 SV=1 PF02017//PF00139//PF02214//PF03388 CIDE-N domain//Legume lectin domain//BTB/POZ domain//Legume-like lectin family GO:0046854//GO:0051260//GO:0006915 phosphatidylinositol phosphorylation//protein homooligomerization//apoptotic process GO:0030246 carbohydrate binding GO:0005622//GO:0016020 intracellular//membrane KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.40839 BP_3 115.30 0.49 11678 642911579 XP_008200659.1 3818 0.0e+00 PREDICTED: patched isoform X1 [Tribolium castaneum] 197276677 NM_001134377.1 158 7.8562e-74 Tribolium castaneum patched (Ptc), mRNA K15013 ACSBG long-chain-fatty-acid--CoA ligase ACSBG http://www.genome.jp/dbget-bin/www_bget?ko:K15013 P18502 1646 4.3e-181 Protein patched OS=Drosophila melanogaster GN=ptc PE=2 SV=2 PF16499//PF03572//PF02460//PF02116//PF00501//PF08941 Alpha galactosidase A//Peptidase family S41//Patched family//Fungal pheromone mating factor STE2 GPCR//AMP-binding enzyme//USP8 interacting GO:0019236//GO:0006508//GO:0016567//GO:0008152//GO:0005975//GO:0007606//GO:0007186//GO:0007165 response to pheromone//proteolysis//protein ubiquitination//metabolic process//carbohydrate metabolic process//sensory perception of chemical stimulus//G-protein coupled receptor signaling pathway//signal transduction GO:0003824//GO:0008236//GO:0004932//GO:0016881//GO:0008158//GO:0031386//GO:0004553 catalytic activity//serine-type peptidase activity//mating-type factor pheromone receptor activity//acid-amino acid ligase activity//hedgehog receptor activity//protein tag//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016020 membrane -- -- Cluster-8309.40841 BP_3 76.23 0.75 5166 390198528 AFL70631.1 2282 8.2e-254 putative hypoxia-inducible factor 1 alpha [Callosobruchus maculatus] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 Q24167 843 2.4e-88 Protein similar OS=Drosophila melanogaster GN=sima PE=1 SV=2 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG3558 Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1 Cluster-8309.40842 BP_3 4597.80 18.26 12426 91092464 XP_970082.1 4337 0.0e+00 PREDICTED: glycine dehydrogenase (decarboxylating), mitochondrial [Tribolium castaneum]>gi|270004725|gb|EFA01173.1| hypothetical protein TcasGA2_TC010496 [Tribolium castaneum] 332372930 BT126644.1 662 0 Dendroctonus ponderosae clone DPO0411_K02 unknown mRNA K00281 GLDC, gcvP glycine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00281 P23378 3262 0.0e+00 Glycine dehydrogenase (decarboxylating), mitochondrial OS=Homo sapiens GN=GLDC PE=1 SV=2 PF01176//PF02347//PF01053//PF01212//PF00344 Translation initiation factor 1A / IF-1//Glycine cleavage system P-protein//Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//SecY translocase GO:0006544//GO:0006546//GO:0006520//GO:0006413//GO:0006446//GO:0055114//GO:0015031//GO:0006566//GO:0006563 glycine metabolic process//glycine catabolic process//cellular amino acid metabolic process//translational initiation//regulation of translational initiation//oxidation-reduction process//protein transport//threonine metabolic process//L-serine metabolic process GO:0004375//GO:0030170//GO:0003723//GO:0016829//GO:0003743 glycine dehydrogenase (decarboxylating) activity//pyridoxal phosphate binding//RNA binding//lyase activity//translation initiation factor activity GO:0016020//GO:0005840 membrane//ribosome KOG2040 Glycine dehydrogenase (decarboxylating) Cluster-8309.40843 BP_3 4725.27 18.46 12632 642913168 XP_008201419.1 3497 0.0e+00 PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum]>gi|642913170|ref|XP_008201420.1| PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum] 642913399 XM_008202772.1 149 8.56038e-69 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X3, mRNA K10358 MYO6 myosin VI http://www.genome.jp/dbget-bin/www_bget?ko:K10358 Q01989 2938 0.0e+00 Myosin heavy chain 95F OS=Drosophila melanogaster GN=jar PE=2 SV=4 PF13465//PF06459//PF02487//PF01363//PF13912//PF02736//PF02892//PF02724//PF01943//PF00437//PF00096//PF05672//PF00612//PF00063 Zinc-finger double domain//Ryanodine Receptor TM 4-6//CLN3 protein//FYVE zinc finger//C2H2-type zinc finger//Myosin N-terminal SH3-like domain//BED zinc finger//CDC45-like protein//Polysaccharide biosynthesis protein//Type II/IV secretion system protein//Zinc finger, C2H2 type//MAP7 (E-MAP-115) family//IQ calmodulin-binding motif//Myosin head (motor domain) GO:0000226//GO:0000271//GO:0006874//GO:0006816//GO:0006270//GO:0006810 microtubule cytoskeleton organization//polysaccharide biosynthetic process//cellular calcium ion homeostasis//calcium ion transport//DNA replication initiation//transport GO:0003774//GO:0046872//GO:0003677//GO:0005219//GO:0005515//GO:0005524 motor activity//metal ion binding//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding//ATP binding GO:0016020//GO:0005622//GO:0016459//GO:0016021//GO:0015630 membrane//intracellular//myosin complex//integral component of membrane//microtubule cytoskeleton KOG0163 Myosin class VI heavy chain Cluster-8309.40844 BP_3 213.21 8.90 1447 443725752 ELU13203.1 1077 1.2e-114 hypothetical protein CAPTEDRAFT_149382 [Capitella teleta] -- -- -- -- -- K01805 xylA xylose isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01805 Q9FKK7 810 4.6e-85 Xylose isomerase OS=Arabidopsis thaliana GN=XYLA PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40845 BP_3 1097.60 53.86 1274 270013979 EFA10427.1 523 1.9e-50 hypothetical protein TcasGA2_TC012668 [Tribolium castaneum] 642935879 XM_008199988.1 39 1.18659e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103314310 (LOC103314310), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40846 BP_3 593.11 18.93 1802 189238341 XP_966817.2 1777 1.0e-195 PREDICTED: sorting and assembly machinery component 50 homolog [Tribolium castaneum] -- -- -- -- -- K07277 SAM50, TOB55, bamA outer membrane protein insertion porin family http://www.genome.jp/dbget-bin/www_bget?ko:K07277 Q6PA35 910 1.5e-96 Sorting and assembly machinery component 50 homolog B OS=Xenopus laevis GN=samm50-b PE=2 SV=1 PF01103 Surface antigen -- -- -- -- GO:0019867 outer membrane KOG2602 Predicted cell surface protein homologous to bacterial outer membrane proteins Cluster-8309.40848 BP_3 11.00 0.38 1697 270015668 EFA12116.1 687 2.4e-69 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8CEE7 455 7.9e-44 Retinol dehydrogenase 13 OS=Mus musculus GN=Rdh13 PE=2 SV=1 PF01370//PF00106//PF01073//PF07465 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//Photosystem I protein M (PsaM) GO:0008152//GO:0008210//GO:0015979//GO:0008207//GO:0006694//GO:0055114//GO:0008209 metabolic process//estrogen metabolic process//photosynthesis//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process GO:0003854//GO:0050662//GO:0003824//GO:0016616//GO:0016491 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- -- -- Cluster-8309.40849 BP_3 121.44 1.00 6132 642929348 XP_008195797.1 3118 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1646 2.2e-181 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF09111//PF08352//PF00225//PF00787//PF00498 SLIDE//Oligopeptide/dipeptide transporter, C-terminal region//Kinesin motor domain//PX domain//FHA domain GO:0015833//GO:0007017//GO:0006338//GO:0007018 peptide transport//microtubule-based process//chromatin remodeling//microtubule-based movement GO:0016818//GO:0003676//GO:0008017//GO:0000166//GO:0035091//GO:0005515//GO:0003777//GO:0005524 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//microtubule binding//nucleotide binding//phosphatidylinositol binding//protein binding//microtubule motor activity//ATP binding GO:0045298//GO:0005874//GO:0005634 tubulin complex//microtubule//nucleus KOG0245 Kinesin-like protein Cluster-8309.40852 BP_3 8.74 2.78 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40853 BP_3 233.17 8.98 1543 242117921 NP_001155991.1 1638 1.2e-179 rhodopsin 1/6-like [Tribolium castaneum]>gi|270007219|gb|EFA03667.1| hypothetical protein TcasGA2_TC013765 [Tribolium castaneum] 197259972 EU921225.1 214 7.54515e-106 Thermonectus marmoratus putative long wavelength opsin mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 P35362 1521 1.8e-167 Rhodopsin OS=Sphodromantis sp. PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0007165//GO:0007601//GO:0018298//GO:0007602 G-protein coupled receptor signaling pathway//signal transduction//visual perception//protein-chromophore linkage//phototransduction GO:0009881//GO:0004930 photoreceptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.40854 BP_3 1423.05 12.11 5955 189233727 XP_970593.2 2892 0.0e+00 PREDICTED: AP-3 complex subunit beta-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12397 AP3B AP-3 complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12397 Q13367 2115 9.0e-236 AP-3 complex subunit beta-2 OS=Homo sapiens GN=AP3B2 PE=1 SV=2 PF13374//PF02862//PF00515//PF09726//PF13371//PF00330//PF02535//PF02985//PF02486//PF13414//PF13181//PF01602//PF13174//PF08492 Tetratricopeptide repeat//DDHD domain//Tetratricopeptide repeat//Transmembrane protein//Tetratricopeptide repeat//Aconitase family (aconitate hydratase)//ZIP Zinc transporter//HEAT repeat//Replication initiation factor//TPR repeat//Tetratricopeptide repeat//Adaptin N terminal region//Tetratricopeptide repeat//SRP72 RNA-binding domain GO:0008152//GO:0030001//GO:0006265//GO:0006614//GO:0055085//GO:0006270//GO:0016192//GO:0006886 metabolic process//metal ion transport//DNA topological change//SRP-dependent cotranslational protein targeting to membrane//transmembrane transport//DNA replication initiation//vesicle-mediated transport//intracellular protein transport GO:0008312//GO:0046873//GO:0046872//GO:0003677//GO:0003916//GO:0005515 7S RNA binding//metal ion transmembrane transporter activity//metal ion binding//DNA binding//DNA topoisomerase activity//protein binding GO:0016020//GO:0030117//GO:0016021//GO:0048500 membrane//membrane coat//integral component of membrane//signal recognition particle KOG1060 Vesicle coat complex AP-3, beta subunit Cluster-8309.40856 BP_3 33.16 0.55 3195 91090840 XP_972191.1 620 2.7e-61 PREDICTED: N-acetyl-D-glucosamine kinase [Tribolium castaneum]>gi|270013990|gb|EFA10438.1| hypothetical protein TcasGA2_TC012681 [Tribolium castaneum] -- -- -- -- -- K00884 NAGK, nagK N-acetylglucosamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00884 Q9QZ08 331 3.5e-29 N-acetyl-D-glucosamine kinase OS=Mus musculus GN=Nagk PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1794 N-Acetylglucosamine kinase Cluster-8309.40857 BP_3 94.27 2.82 1903 91086285 XP_967226.1 1304 7.7e-141 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 946 1.0e-100 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.40859 BP_3 38.57 1.01 2134 546681329 ERL91443.1 1890 9.6e-209 hypothetical protein D910_08773 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 284 6.7e-24 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 PF01155//PF06905//PF00856 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Fas apoptotic inhibitory molecule (FAIM1)//SET domain GO:0006464//GO:0043066 cellular protein modification process//negative regulation of apoptotic process GO:0005515//GO:0016151 protein binding//nickel cation binding -- -- -- -- Cluster-8309.40862 BP_3 18.60 1.45 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40864 BP_3 67.94 1.03 3481 270001283 EEZ97730.1 2618 6.0e-293 stumps [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.9e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF16934//PF04136 Two-component Enterococcus faecalis cytolysin (EFC)//Sec34-like family GO:0006886//GO:0050830 intracellular protein transport//defense response to Gram-positive bacterium -- -- GO:0005801//GO:0016020 cis-Golgi network//membrane -- -- Cluster-8309.40866 BP_3 291.16 1.90 7687 642939018 XP_008198083.1 835 7.5e-86 PREDICTED: protein SCAF8 isoform X2 [Tribolium castaneum] 195123078 XM_002006001.1 64 9.27248e-22 Drosophila mojavensis GI18767 (Dmoj\GI18767), mRNA K13191 RBM16, SCAF8 RNA-binding protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13191 Q6DID3 568 2.8e-56 Protein SCAF8 OS=Mus musculus GN=Scaf8 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0132 RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains Cluster-8309.40867 BP_3 1353.56 9.94 6858 642939018 XP_008198083.1 1297 1.8e-139 PREDICTED: protein SCAF8 isoform X2 [Tribolium castaneum] 195123078 XM_002006001.1 64 8.26765e-22 Drosophila mojavensis GI18767 (Dmoj\GI18767), mRNA K13191 RBM16, SCAF8 RNA-binding protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13191 Q6DID3 568 2.5e-56 Protein SCAF8 OS=Mus musculus GN=Scaf8 PE=1 SV=1 PF01080//PF00076 Presenilin//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG0132 RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains Cluster-8309.40869 BP_3 11.20 1.10 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02751 Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.40871 BP_3 1707.87 13.58 6355 91081951 XP_967254.1 2017 5.4e-223 PREDICTED: LIM domain-containing protein jub isoform X2 [Tribolium castaneum]>gi|270007323|gb|EFA03771.1| hypothetical protein TcasGA2_TC013882 [Tribolium castaneum] 170045329 XM_001850215.1 328 1.34067e-168 Culex quinquefasciatus limd1, mRNA K16682 AJUBA, LIMD1, WTIP LIM domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K16682 Q9VY77 1217 1.3e-131 LIM domain-containing protein jub OS=Drosophila melanogaster GN=jub PE=1 SV=3 PF00400//PF04185//PF00412 WD domain, G-beta repeat//Phosphoesterase family//LIM domain -- -- GO:0005515//GO:0016788//GO:0008270//GO:0043169 protein binding//hydrolase activity, acting on ester bonds//zinc ion binding//cation binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.40872 BP_3 14.84 0.49 1740 91081951 XP_967254.1 867 3.3e-90 PREDICTED: LIM domain-containing protein jub isoform X2 [Tribolium castaneum]>gi|270007323|gb|EFA03771.1| hypothetical protein TcasGA2_TC013882 [Tribolium castaneum] 194895275 XM_001978183.1 238 3.88566e-119 Drosophila erecta GG19482 (Dere\GG19482), mRNA K16682 AJUBA, LIMD1, WTIP LIM domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K16682 Q9VY77 798 1.4e-83 LIM domain-containing protein jub OS=Drosophila melanogaster GN=jub PE=1 SV=3 PF00412 LIM domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.40874 BP_3 848.21 13.81 3253 189234994 XP_969025.2 2102 3.8e-233 PREDICTED: protein SMG7-like [Tribolium castaneum] -- -- -- -- -- K14409 SMG7, EST1C protein SMG7 http://www.genome.jp/dbget-bin/www_bget?ko:K14409 Q92540 806 3.0e-84 Protein SMG7 OS=Homo sapiens GN=SMG7 PE=1 SV=2 PF07776//PF13181//PF13414//PF13176 Zinc-finger associated domain (zf-AD)//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus KOG2162 Nonsense-mediated mRNA decay protein Cluster-8309.40876 BP_3 2003.91 26.38 3953 642939400 XP_008193248.1 467 1.8e-43 PREDICTED: uncharacterized protein LOC103312106 [Tribolium castaneum]>gi|270016475|gb|EFA12921.1| hypothetical protein TcasGA2_TC006991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.40880 BP_3 74.00 1.10 3536 91079020 XP_974879.1 1898 1.9e-209 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q863B3 1012 4.2e-108 Staphylococcal nuclease domain-containing protein 1 OS=Bos taurus GN=SND1 PE=1 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.40882 BP_3 49.88 0.67 3869 478250663 ENN71155.1 1488 7.2e-162 hypothetical protein YQE_12086, partial [Dendroctonus ponderosae]>gi|546677247|gb|ERL88116.1| hypothetical protein D910_05505 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 801 1.4e-83 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF00487//PF08320 Fatty acid desaturase//PIG-X / PBN1 GO:0006506//GO:0006629 GPI anchor biosynthetic process//lipid metabolic process -- -- GO:0005789 endoplasmic reticulum membrane KOG0537 Cytochrome b5 Cluster-8309.40883 BP_3 433.65 5.08 4403 478255294 ENN75520.1 4929 0.0e+00 hypothetical protein YQE_07864, partial [Dendroctonus ponderosae] 585685897 XM_006820162.1 113 3.05425e-49 PREDICTED: Saccoglossus kowalevskii brefeldin A-inhibited guanine nucleotide-exchange protein 1-like (LOC100366823), mRNA K18442 ARFGEF, BIG brefeldin A-inhibited guanine nucleotide-exchange protein http://www.genome.jp/dbget-bin/www_bget?ko:K18442 Q9Y6D6 3777 0.0e+00 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens GN=ARFGEF1 PE=1 SV=2 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0929 Guanine nucleotide exchange factor Cluster-8309.40884 BP_3 2236.03 25.24 4561 270008370 EFA04818.1 1154 4.6e-123 hypothetical protein TcasGA2_TC014868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SWR8 600 3.3e-60 Ataxin-2 homolog OS=Drosophila melanogaster GN=Atx2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2375 Protein interacting with poly(A)-binding protein Cluster-8309.40886 BP_3 128.10 9.06 973 270013731 EFA10179.1 908 3.3e-95 hypothetical protein TcasGA2_TC012371 [Tribolium castaneum] -- -- -- -- -- K13142 INTS5 integrator complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13142 Q6P9B9 285 2.3e-24 Integrator complex subunit 5 OS=Homo sapiens GN=INTS5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40887 BP_3 22.00 97.57 1434 241598585 XP_002404762.1 314 3.6e-26 ADP ribosylation factor 79F, putative [Ixodes scapularis]>gi|215500482|gb|EEC09976.1| ADP ribosylation factor 79F, putative [Ixodes scapularis] 642935820 XM_008199967.1 116 2.1037e-51 PREDICTED: Tribolium castaneum ADP-ribosylation factor 1 (LOC656788), transcript variant X3, mRNA K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 P0CM17 306 1.3e-26 ADP-ribosylation factor OS=Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) GN=ARF PE=3 SV=1 PF08477//PF01239//PF00503//PF04670//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein prenyltransferase alpha subunit repeat//G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family GO:0007264//GO:0007186//GO:0018342//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//protein prenylation//signal transduction GO:0004871//GO:0019001//GO:0008318//GO:0005525//GO:0003924//GO:0031683 signal transducer activity//guanyl nucleotide binding//protein prenyltransferase activity//GTP binding//GTPase activity//G-protein beta/gamma-subunit complex binding GO:0005622 intracellular KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.40888 BP_3 177.58 1.21 7390 91083005 XP_974497.1 1587 4.6e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit H [Tribolium castaneum]>gi|270007645|gb|EFA04093.1| hypothetical protein TcasGA2_TC014327 [Tribolium castaneum] -- -- -- -- -- K03247 EIF3H translation initiation factor 3 subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K03247 Q9GV27 1431 2.3e-156 Eukaryotic translation initiation factor 3 subunit H OS=Bombyx mori PE=2 SV=1 PF01398//PF04961//PF00622//PF07525//PF09596 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//SPRY domain//SOCS box//MamL-1 domain GO:0035556//GO:0007219//GO:0045944//GO:0044237 intracellular signal transduction//Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0005515//GO:0003713 catalytic activity//protein binding//transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex KOG1560 Translation initiation factor 3, subunit h (eIF-3h) Cluster-8309.40889 BP_3 75.00 1.84 2259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4089 BP_3 34.00 5.23 605 221136975 NP_001137600.1 151 1.2e-07 gustatory receptor [Tribolium castaneum]>gi|642925349|ref|XP_008194515.1| PREDICTED: gustatory receptor [Tribolium castaneum]>gi|163716744|gb|ABY40596.1| gustatory receptor [Tribolium castaneum]>gi|270009332|gb|EFA05780.1| gustatory receptor 70 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395//PF06151 7tm Chemosensory receptor//Trehalose receptor GO:0007607//GO:0050909//GO:0007187//GO:0050912 obsolete taste perception//sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.40892 BP_3 78.42 0.31 12435 91093683 XP_970017.1 1672 1.1e-182 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 3.4e-75 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01553//PF00115 Acyltransferase//Cytochrome C and Quinol oxidase polypeptide I GO:0006118//GO:0055114//GO:0015992//GO:0009060//GO:0008152//GO:0006123 obsolete electron transport//oxidation-reduction process//proton transport//aerobic respiration//metabolic process//mitochondrial electron transport, cytochrome c to oxygen GO:0009055//GO:0005506//GO:0004129//GO:0020037//GO:0016746 electron carrier activity//iron ion binding//cytochrome-c oxidase activity//heme binding//transferase activity, transferring acyl groups GO:0016021//GO:0045277 integral component of membrane//respiratory chain complex IV KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.40893 BP_3 64.86 3.06 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40894 BP_3 260.99 3.66 3731 546677329 ERL88186.1 1326 4.2e-143 hypothetical protein D910_05574 [Dendroctonus ponderosae] -- -- -- -- -- K17407 MRPS28 small subunit ribosomal protein S28 http://www.genome.jp/dbget-bin/www_bget?ko:K17407 Q9CY16 323 3.5e-28 28S ribosomal protein S28, mitochondrial OS=Mus musculus GN=Mrps28 PE=1 SV=1 PF06788 Uncharacterised protein family (UPF0257) -- -- -- -- GO:0005886 plasma membrane KOG4078 Putative mitochondrial ribosomal protein mRpS35 Cluster-8309.40895 BP_3 872.00 8.30 5355 91084933 XP_970918.1 4699 0.0e+00 PREDICTED: DNA-directed RNA polymerase I subunit RPA1 [Tribolium castaneum]>gi|270008555|gb|EFA05003.1| hypothetical protein TcasGA2_TC015082 [Tribolium castaneum] 593716780 XM_007104772.1 122 3.69384e-54 PREDICTED: Physeter catodon polymerase (RNA) I polypeptide A, 194kDa (POLR1A), mRNA K02999 RPA1, POLR1A DNA-directed RNA polymerase I subunit RPA1 http://www.genome.jp/dbget-bin/www_bget?ko:K02999 P91875 3292 0.0e+00 DNA-directed RNA polymerase I subunit RPA1 OS=Drosophila melanogaster GN=RpI1 PE=1 SV=2 PF04983//PF05000//PF04147//PF04998//PF02724//PF04997//PF07168//PF00623 RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 4//Nop14-like family//RNA polymerase Rpb1, domain 5//CDC45-like protein//RNA polymerase Rpb1, domain 1//Ureide permease//RNA polymerase Rpb1, domain 2 GO:0071705//GO:0006351//GO:0006270//GO:0006144//GO:0006206 nitrogen compound transport//transcription, DNA-templated//DNA replication initiation//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0008270 DNA binding//DNA-directed RNA polymerase activity//zinc ion binding GO:0005634//GO:0005730//GO:0032040 nucleus//nucleolus//small-subunit processome KOG0262 RNA polymerase I, large subunit Cluster-8309.40896 BP_3 8.94 0.31 1663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40897 BP_3 248.45 10.65 1416 478249904 ENN70411.1 502 5.7e-48 hypothetical protein YQE_12917, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH14 183 2.3e-12 Tissue inhibitor of metalloproteases OS=Drosophila melanogaster GN=Timp PE=2 SV=1 PF00965//PF13673 Tissue inhibitor of metalloproteinase//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0008191 N-acetyltransferase activity//metalloendopeptidase inhibitor activity -- -- -- -- Cluster-8309.40898 BP_3 499.08 22.23 1374 546677533 ERL88352.1 606 4.8e-60 hypothetical protein D910_05739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH14 273 8.1e-23 Tissue inhibitor of metalloproteases OS=Drosophila melanogaster GN=Timp PE=2 SV=1 PF13673//PF00965 Acetyltransferase (GNAT) domain//Tissue inhibitor of metalloproteinase GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0008191 N-acetyltransferase activity//metalloendopeptidase inhibitor activity -- -- -- -- Cluster-8309.40899 BP_3 249.48 17.89 964 642913085 XP_008201384.1 581 2.7e-57 PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum]>gi|642913087|ref|XP_008201386.1| PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum] 642913086 XM_008203164.1 219 7.73394e-109 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X9, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 314 1.0e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.40901 BP_3 92.32 2.28 2242 741829289 AJA91071.1 1466 1.5e-159 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1061 5.6e-114 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.40902 BP_3 242.93 2.53 4925 573884393 XP_006630279.1 261 1.7e-19 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 729-like [Lepisosteus oculatus] 642937236 XM_008200529.1 145 5.5621e-67 PREDICTED: Tribolium castaneum zinc finger protein 1 (LOC100141776), transcript variant X4, mRNA K09299 ZEB1_2 zinc finger homeobox protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K09299 Q03936 256 2.7e-20 Zinc finger protein 92 OS=Homo sapiens GN=ZNF92 PE=2 SV=2 PF01155//PF00046//PF13465//PF00096//PF05920//PF13912 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Homeobox domain//Zinc-finger double domain//Zinc finger, C2H2 type//Homeobox KN domain//C2H2-type zinc finger GO:0006355//GO:0006464 regulation of transcription, DNA-templated//cellular protein modification process GO:0003677//GO:0016151//GO:0046872 DNA binding//nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.40903 BP_3 178.60 0.80 10999 642918318 XP_008191457.1 7327 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 195492470 XM_002093969.1 257 6.84408e-129 Drosophila yakuba GE20438 (Dyak\GE20438), partial mRNA -- -- -- -- Q9VS29 6236 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF07749//PF16656//PF13895//PF04120//PF00041 Endoplasmic reticulum protein ERp29, C-terminal domain//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Low affinity iron permease//Fibronectin type III domain GO:0019497//GO:0006771//GO:0055085 hexachlorocyclohexane metabolic process//riboflavin metabolic process//transmembrane transport GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.40904 BP_3 204.48 3.00 3576 189235221 XP_967494.2 2010 2.0e-222 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15047 HNRNPUL1, E1BAP5 heterogeneous nuclear ribonucleoprotein U-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15047 Q9BUJ2 758 1.2e-78 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens GN=HNRNPUL1 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.40905 BP_3 53.19 3.01 1144 642915944 XP_008190822.1 472 1.4e-44 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X1 [Tribolium castaneum]>gi|270003748|gb|EFA00196.1| hypothetical protein TcasGA2_TC003021 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00PI9 157 1.9e-09 Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Mus musculus GN=Hnrnpul2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40907 BP_3 336.89 6.31 2864 642918268 XP_008191439.1 1540 5.0e-168 PREDICTED: methoprene-tolerant isoform X1 [Tribolium castaneum]>gi|207367000|dbj|BAG71980.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZQU2 294 6.2e-25 Neuronal PAS domain-containing protein 2 OS=Gallus gallus GN=NPAS2 PE=1 SV=1 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0046983//GO:0004871//GO:0003700 DNA binding//protein binding//protein dimerization activity//signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.40908 BP_3 21340.79 246.12 4471 642927501 XP_008195294.1 965 3.7e-101 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26, partial [Tribolium castaneum] -- -- -- -- -- K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 -- -- -- -- PF03427 Carbohydrate binding domain (family 19) GO:0006032 chitin catabolic process GO:0008061 chitin binding -- -- -- -- Cluster-8309.40909 BP_3 13.00 0.71 1174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40911 BP_3 169.34 2.14 4101 91081613 XP_966546.1 1370 3.7e-148 PREDICTED: protein goliath-like [Tribolium castaneum] 768414717 XM_011549573.1 128 1.30415e-57 PREDICTED: Plutella xylostella protein goliath (LOC105380077), mRNA -- -- -- -- Q06003 711 3.9e-73 Protein goliath OS=Drosophila melanogaster GN=gol PE=2 SV=3 PF13639//PF00335//PF12861//PF06667//PF00097//PF17123//PF12678//PF14634 Ring finger domain//Tetraspanin family//Anaphase-promoting complex subunit 11 RING-H2 finger//Phage shock protein B//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain GO:0009271//GO:0016567//GO:0006355 phage shock//protein ubiquitination//regulation of transcription, DNA-templated GO:0004842//GO:0005515//GO:0008270//GO:0046872 ubiquitin-protein transferase activity//protein binding//zinc ion binding//metal ion binding GO:0016021//GO:0005680 integral component of membrane//anaphase-promoting complex KOG4628 Predicted E3 ubiquitin ligase Cluster-8309.40912 BP_3 110.10 0.68 8055 642931705 XP_008196694.1 6622 0.0e+00 PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum]>gi|642931707|ref|XP_008196695.1| PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum] -- -- -- -- -- K06640 ATR serine/threonine-protein kinase ATR http://www.genome.jp/dbget-bin/www_bget?ko:K06640 Q9VXG8 2331 1.1e-260 Serine/threonine-protein kinase ATR OS=Drosophila melanogaster GN=mei-41 PE=1 SV=2 PF00454//PF02260//PF08064//PF02259 Phosphatidylinositol 3- and 4-kinase//FATC domain//UME (NUC010) domain//FAT domain GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0005515//GO:0004674 phosphotransferase activity, alcohol group as acceptor//protein binding//protein serine/threonine kinase activity -- -- KOG0890 Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination Cluster-8309.40914 BP_3 3.32 1.99 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09297 NADH pyrophosphatase zinc ribbon domain -- -- GO:0046872//GO:0016787 metal ion binding//hydrolase activity -- -- -- -- Cluster-8309.40915 BP_3 201.51 2.39 4362 642912192 XP_008200846.1 754 1.1e-76 PREDICTED: transmembrane protein 127-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGP5 216 1.0e-15 Transmembrane protein 127 OS=Mus musculus GN=Tmem127 PE=2 SV=1 PF00515//PF04799 Tetratricopeptide repeat//fzo-like conserved region GO:0008053 mitochondrial fusion GO:0003924//GO:0005515 GTPase activity//protein binding GO:0005741//GO:0016021 mitochondrial outer membrane//integral component of membrane -- -- Cluster-8309.40916 BP_3 33.00 0.55 3167 478251864 ENN72303.1 1127 4.3e-120 hypothetical protein YQE_11046, partial [Dendroctonus ponderosae]>gi|546674377|gb|ERL85764.1| hypothetical protein D910_03179 [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 2.1e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.40919 BP_3 796.33 16.42 2629 642912272 XP_008200632.1 843 3.0e-87 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00187 253 3.2e-20 Mannan-binding lectin serine protease 2 OS=Homo sapiens GN=MASP2 PE=1 SV=4 PF00089//PF04272//PF01414 Trypsin//Phospholamban//Delta serrate ligand GO:0006508//GO:0007154//GO:0006816//GO:0006810 proteolysis//cell communication//calcium ion transport//transport GO:0004252//GO:0005246//GO:0042030 serine-type endopeptidase activity//calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.40921 BP_3 292.00 38.85 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40922 BP_3 1451.00 42.40 1941 546678980 ERL89513.1 1262 5.8e-136 hypothetical protein D910_06879 [Dendroctonus ponderosae] 850318596 XM_013007893.1 39 1.82538e-08 PREDICTED: Echinops telfairi L-lactate dehydrogenase A chain-like (LOC101645051), mRNA K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 1148 3.9e-124 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF02737//PF02866//PF00056//PF03721//PF02427 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//lactate/malate dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Photosystem I reaction centre subunit IV / PsaE GO:0006574//GO:0006550//GO:0055114//GO:0006554//GO:0006568//GO:0006633//GO:0018874//GO:0015979//GO:0006552//GO:0006631 valine catabolic process//isoleucine catabolic process//oxidation-reduction process//lysine catabolic process//tryptophan metabolic process//fatty acid biosynthetic process//benzoate metabolic process//photosynthesis//leucine catabolic process//fatty acid metabolic process GO:0016616//GO:0003857//GO:0051287//GO:0016491 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//NAD binding//oxidoreductase activity GO:0009522//GO:0009538 photosystem I//photosystem I reaction center KOG1495 Lactate dehydrogenase Cluster-8309.40925 BP_3 278.24 1.23 11181 270015748 EFA12196.1 1838 5.4e-202 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TT16 248 5.2e-19 Inositol polyphosphate multikinase OS=Mus musculus GN=Ipmk PE=2 SV=1 PF16716//PF05529//PF00096//PF00867//PF03770//PF00695//PF04111//PF01218//PF08702//PF01105//PF10473//PF00642//PF03938//PF13912 Bone marrow stromal antigen 2//B-cell receptor-associated protein 31-like//Zinc finger, C2H2 type//XPG I-region//Inositol polyphosphate kinase//Major surface antigen from hepadnavirus//Autophagy protein Apg6//Coproporphyrinogen III oxidase//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Outer membrane protein (OmpH-like)//C2H2-type zinc finger GO:0030168//GO:0015994//GO:0051607//GO:0016032//GO:0006779//GO:0055114//GO:0006810//GO:0006886//GO:0006914//GO:0051258//GO:0007165 platelet activation//chlorophyll metabolic process//defense response to virus//viral process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//transport//intracellular protein transport//autophagy//protein polymerization//signal transduction GO:0046872//GO:0004518//GO:0030674//GO:0042803//GO:0004109//GO:0005102//GO:0008440//GO:0051082//GO:0045502//GO:0008134 metal ion binding//nuclease activity//protein binding, bridging//protein homodimerization activity//coproporphyrinogen oxidase activity//receptor binding//inositol-1,4,5-trisphosphate 3-kinase activity//unfolded protein binding//dynein binding//transcription factor binding GO:0005783//GO:0005667//GO:0030286//GO:0005577//GO:0016021 endoplasmic reticulum//transcription factor complex//dynein complex//fibrinogen complex//integral component of membrane -- -- Cluster-8309.40926 BP_3 2.00 1.78 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40927 BP_3 1105.58 21.19 2806 642921258 XP_008192788.1 1049 4.2e-111 PREDICTED: serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [Tribolium castaneum] 573910381 XM_006642846.1 210 2.31845e-103 PREDICTED: Lepisosteus oculatus serine/threonine-protein phosphatase PP1-beta catalytic subunit-like (LOC102696354), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q5I085 1017 8.9e-109 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Xenopus tropicalis GN=ppp1cb PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.40928 BP_3 30.00 0.42 3730 91082177 XP_971147.1 608 7.6e-60 PREDICTED: transmembrane protein 35 [Tribolium castaneum]>gi|270007236|gb|EFA03684.1| hypothetical protein TcasGA2_TC013786 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9T5 193 4.2e-13 Transmembrane protein 35 OS=Bos taurus GN=TMEM35 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40930 BP_3 21.82 0.37 3107 642920332 XP_975626.2 1424 1.5e-154 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] 195397078 XM_002057120.1 100 3.6196e-42 Drosophila virilis GJ16936 (Dvir\GJ16936), mRNA -- -- -- -- Q6TYB5 388 8.5e-36 Fasciculation and elongation protein zeta-2 OS=Mus musculus GN=Fez2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.40931 BP_3 15.98 0.34 2531 189239405 XP_001813943.1 2659 7.7e-298 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] 637379439 XM_008125298.1 41 1.84791e-09 PREDICTED: Anolis carolinensis nuclear export mediator factor NEMF-like (LOC103282578), mRNA -- -- -- -- O60524 1750 8.1e-194 Nuclear export mediator factor NEMF OS=Homo sapiens GN=NEMF PE=1 SV=4 PF08052//PF02050//PF05615 PyrBI operon leader peptide//Flagellar FliJ protein//Tho complex subunit 7 GO:0006397//GO:0006935//GO:0071973//GO:0019856 mRNA processing//chemotaxis//bacterial-type flagellum-dependent cell motility//pyrimidine nucleobase biosynthetic process GO:0003774 motor activity GO:0016020//GO:0009288//GO:0000445 membrane//bacterial-type flagellum//THO complex part of transcription export complex KOG2030 Predicted RNA-binding protein Cluster-8309.40934 BP_3 1659.66 40.62 2261 642924570 XP_008194348.1 691 1.1e-69 PREDICTED: probable signal peptidase complex subunit 2 [Tribolium castaneum]>gi|270006751|gb|EFA03199.1| hypothetical protein TcasGA2_TC013119 [Tribolium castaneum] -- -- -- -- -- K12947 SPCS2, SPC2 signal peptidase complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12947 Q28250 519 4.0e-51 Signal peptidase complex subunit 2 OS=Canis familiaris GN=SPCS2 PE=1 SV=1 PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-8309.40935 BP_3 2319.53 49.64 2544 91083815 XP_973428.1 297 6.0e-24 PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924518|ref|XP_008194328.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924520|ref|XP_008194329.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|270007930|gb|EFA04378.1| hypothetical protein TcasGA2_TC014676 [Tribolium castaneum] 242011614 XM_002426498.1 39 2.40287e-08 Pediculus humanus corporis hypothetical protein, mRNA K11587 CBX5, HP1A chromobox protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11587 Q61686 246 2.0e-19 Chromobox protein homolog 5 OS=Mus musculus GN=Cbx5 PE=1 SV=1 PF04689//PF01393 DNA binding protein S1FA//Chromo shadow domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.40938 BP_3 18.00 16.03 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40939 BP_3 29.41 0.59 2685 91076170 XP_971503.1 1884 6.0e-208 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 353 0 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 503 3.4e-49 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.40940 BP_3 1188.94 6.43 9209 270002460 EEZ98907.1 4932 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1803 2.1e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF02148//PF01363//PF07649 Zn-finger in ubiquitin-hydrolases and other protein//FYVE zinc finger//C1-like domain GO:0055114 oxidation-reduction process GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.40941 BP_3 1224.34 12.02 5203 642911378 XP_008199399.1 1861 5.4e-205 PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911380|ref|XP_008199400.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911382|ref|XP_008199401.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911384|ref|XP_008199402.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911386|ref|XP_008199403.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911388|ref|XP_008199404.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum] 642911387 XM_008201182.1 520 0 PREDICTED: Tribolium castaneum myocyte-specific enhancer factor 2 (LOC660448), transcript variant X6, mRNA K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 941 1.1e-99 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.40942 BP_3 420.96 20.16 1298 478255506 ENN75723.1 727 4.2e-74 hypothetical protein YQE_07683, partial [Dendroctonus ponderosae]>gi|546676756|gb|ERL87712.1| hypothetical protein D910_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K02939 RP-L9, MRPL9, rplI large subunit ribosomal protein L9 http://www.genome.jp/dbget-bin/www_bget?ko:K02939 Q9VF89 604 3.2e-61 39S ribosomal protein L9, mitochondrial OS=Drosophila melanogaster GN=mRpL9 PE=2 SV=1 PF06422 CDR ABC transporter GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG4607 Mitochondrial ribosomal protein L9 Cluster-8309.40943 BP_3 9337.24 105.07 4575 642916846 XP_008199527.1 814 1.2e-83 PREDICTED: failed axon connections isoform X2 [Tribolium castaneum]>gi|270003072|gb|EEZ99519.1| hypothetical protein TcasGA2_TC000100 [Tribolium castaneum] 642916844 XM_963303.3 271 4.67697e-137 PREDICTED: Tribolium castaneum failed axon connections (LOC656797), transcript variant X1, mRNA -- -- -- -- Q95RI5 693 5.4e-71 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF02724//PF16834//PF06213//PF02535//PF06459//PF13417//PF05132 CDC45-like protein//Shu complex component Csm2, DNA-binding//Cobalamin biosynthesis protein CobT//ZIP Zinc transporter//Ryanodine Receptor TM 4-6//Glutathione S-transferase, N-terminal domain//RNA polymerase III RPC4 GO:0006206//GO:0000725//GO:0030001//GO:0006351//GO:0006383//GO:0006144//GO:0006874//GO:0009236//GO:0055085//GO:0006816//GO:0006270 pyrimidine nucleobase metabolic process//recombinational repair//metal ion transport//transcription, DNA-templated//transcription from RNA polymerase III promoter//purine nucleobase metabolic process//cellular calcium ion homeostasis//cobalamin biosynthetic process//transmembrane transport//calcium ion transport//DNA replication initiation GO:0046873//GO:0003677//GO:0005219//GO:0005515//GO:0003899 metal ion transmembrane transporter activity//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding//DNA-directed RNA polymerase activity GO:0097196//GO:0016020//GO:0005634//GO:0005622//GO:0005666//GO:0005730//GO:0016021 Shu complex//membrane//nucleus//intracellular//DNA-directed RNA polymerase III complex//nucleolus//integral component of membrane -- -- Cluster-8309.40946 BP_3 45.90 2.46 1191 91081119 XP_975527.1 773 1.8e-79 PREDICTED: lipoyl synthase, mitochondrial [Tribolium castaneum]>gi|270006027|gb|EFA02475.1| hypothetical protein TcasGA2_TC008166 [Tribolium castaneum] 675228061 LK023128.1 51 2.36279e-15 Plasmodium berghei ANKA genome assembly PBANKA01, chromosome : 13 K03644 lipA lipoic acid synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K03644 B3NIL9 702 1.3e-72 Lipoyl synthase, mitochondrial OS=Drosophila erecta GN=Las PE=3 SV=1 PF04055 Radical SAM superfamily GO:0044238//GO:0044237//GO:0071704 primary metabolic process//cellular metabolic process//organic substance metabolic process GO:0016783//GO:0051536//GO:0003824 sulfurtransferase activity//iron-sulfur cluster binding//catalytic activity -- -- KOG2672 Lipoate synthase Cluster-8309.40948 BP_3 122.75 1.28 4913 642930284 XP_008196328.1 1023 7.6e-108 PREDICTED: fanconi-associated nuclease 1 homolog isoform X1 [Tribolium castaneum]>gi|270010701|gb|EFA07149.1| hypothetical protein TcasGA2_TC010140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LWH4 450 8.7e-43 Fanconi-associated nuclease 1 OS=Danio rerio GN=fan1 PE=2 SV=2 PF08774 VRR-NUC domain -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2143 Uncharacterized conserved protein Cluster-8309.40951 BP_3 1049.89 7.34 7182 642936633 XP_008198516.1 3023 0.0e+00 PREDICTED: trafficking kinesin-binding protein milt isoform X1 [Tribolium castaneum]>gi|270013061|gb|EFA09509.1| hypothetical protein TcasGA2_TC011611 [Tribolium castaneum] 642936632 XM_008200294.1 364 0 PREDICTED: Tribolium castaneum trafficking kinesin-binding protein milt (LOC661863), transcript variant X1, mRNA K15369 TRAK1 trafficking kinesin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15369 Q960V3 741 2.3e-76 Trafficking kinesin-binding protein milt OS=Drosophila melanogaster GN=milt PE=1 SV=1 PF02262//PF08702//PF01496//PF04513//PF15182//PF06009//PF04111 CBL proto-oncogene N-terminal domain 1//Fibrinogen alpha/beta chain family//V-type ATPase 116kDa subunit family//Baculovirus polyhedron envelope protein, PEP, C terminus//Otospiralin//Laminin Domain II//Autophagy protein Apg6 GO:0007155//GO:0030168//GO:0015991//GO:0015992//GO:0007166//GO:0007165//GO:0006914//GO:0051258//GO:0007605 cell adhesion//platelet activation//ATP hydrolysis coupled proton transport//proton transport//cell surface receptor signaling pathway//signal transduction//autophagy//protein polymerization//sensory perception of sound GO:0030674//GO:0004871//GO:0015078//GO:0005102//GO:0005198 protein binding, bridging//signal transducer activity//hydrogen ion transmembrane transporter activity//receptor binding//structural molecule activity GO:0033179//GO:0005634//GO:0019031//GO:0005577//GO:0019028 proton-transporting V-type ATPase, V0 domain//nucleus//viral envelope//fibrinogen complex//viral capsid -- -- Cluster-8309.40953 BP_3 1090.97 16.79 3423 189234059 XP_969658.2 2716 2.6e-304 PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|642911998|ref|XP_008199054.1| PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|270014437|gb|EFA10885.1| hypothetical protein TcasGA2_TC001709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TWI9 1057 2.5e-113 CSC1-like protein 2 OS=Mus musculus GN=Tmem63b PE=1 SV=1 PF02714 Calcium-dependent channel, 7TM region, putative phosphate -- -- -- -- GO:0016020 membrane KOG1134 Uncharacterized conserved protein Cluster-8309.40955 BP_3 1764.71 162.86 814 642926727 XP_008194988.1 442 3.0e-41 PREDICTED: phenoloxidase subunit A3 [Tribolium castaneum]>gi|270009214|gb|EFA05662.1| hypothetical protein TcasGA2_TC014907 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V521 402 5.3e-38 Phenoloxidase 2 OS=Drosophila melanogaster GN=PPO2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40957 BP_3 154.10 2.58 3175 820805526 AKG92754.1 881 1.4e-91 usf [Leptinotarsa decemlineata] 641661239 XM_008183586.1 156 2.74122e-73 PREDICTED: Acyrthosiphon pisum chromatin modifying protein 2A (Chmp2a), transcript variant X7, mRNA K12191 CHMP2A charged multivesicular body protein 2A http://www.genome.jp/dbget-bin/www_bget?ko:K12191 Q6DFS6 458 6.6e-44 Charged multivesicular body protein 2a OS=Xenopus tropicalis GN=chmp2a PE=2 SV=1 PF04152//PF05848//PF04420//PF06156//PF05615//PF01346//PF06729//PF03357//PF00010 Mre11 DNA-binding presumed domain//Firmicute transcriptional repressor of class III stress genes (CtsR)//CHD5-like protein//Protein of unknown function (DUF972)//Tho complex subunit 7//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Kinetochore component, CENP-R//Snf7//Helix-loop-helix DNA-binding domain GO:0007034//GO:0006302//GO:0006355//GO:0071816//GO:0006260//GO:0034080//GO:0006950//GO:0006397//GO:0006457 vacuolar transport//double-strand break repair//regulation of transcription, DNA-templated//tail-anchored membrane protein insertion into ER membrane//DNA replication//CENP-A containing nucleosome assembly//response to stress//mRNA processing//protein folding GO:0046983//GO:0030145//GO:0004519//GO:0003677 protein dimerization activity//manganese ion binding//endonuclease activity//DNA binding GO:0000445//GO:0005634 THO complex part of transcription export complex//nucleus KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.40959 BP_3 173.22 3.48 2689 270003134 EEZ99581.1 841 5.3e-87 hypothetical protein TcasGA2_TC001567 [Tribolium castaneum] -- -- -- -- -- K13196 DPF2, REQ zinc finger protein ubi-d4 http://www.genome.jp/dbget-bin/www_bget?ko:K13196 Q61103 255 1.9e-20 Zinc finger protein ubi-d4 OS=Mus musculus GN=Dpf2 PE=1 SV=1 PF02064 MAS20 protein import receptor GO:0006886//GO:0006605 intracellular protein transport//protein targeting -- -- GO:0005742 mitochondrial outer membrane translocase complex KOG4056 Translocase of outer mitochondrial membrane complex, subunit TOM20 Cluster-8309.40960 BP_3 661.27 6.45 5231 642918013 XP_008198979.1 1028 2.1e-108 PREDICTED: cytochrome c1, heme protein, mitochondrial [Tribolium castaneum]>gi|270004913|gb|EFA01361.1| mitochondrial cytochrome c1 [Tribolium castaneum] -- -- -- -- -- K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 744 7.5e-77 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF00034//PF02167//PF13442 Cytochrome c//Cytochrome C1 family//Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0009055//GO:0005488//GO:0020037 electron carrier activity//binding//heme binding -- -- KOG3052 Cytochrome c1 Cluster-8309.40961 BP_3 329.00 14.52 1384 91091780 XP_969605.1 1011 5.3e-107 PREDICTED: ubiquitin thioesterase OTU1 [Tribolium castaneum]>gi|270000841|gb|EEZ97288.1| hypothetical protein TcasGA2_TC011093 [Tribolium castaneum] -- -- -- -- -- K13719 OTU1, YOD1 ubiquitin thioesterase OTU1 http://www.genome.jp/dbget-bin/www_bget?ko:K13719 Q5F3A6 606 2.0e-61 Ubiquitin thioesterase OTU1 OS=Gallus gallus GN=YOD1 PE=2 SV=1 PF00240//PF00789 Ubiquitin family//UBX domain -- -- GO:0005515 protein binding -- -- KOG3288 OTU-like cysteine protease Cluster-8309.40964 BP_3 185.38 0.88 10413 642918328 XP_008199102.1 6665 0.0e+00 PREDICTED: otoferlin-like [Tribolium castaneum] 662203764 XM_008477009.1 153 4.21441e-71 PREDICTED: Diaphorina citri otoferlin-like (LOC103512257), partial mRNA -- -- -- -- Q5SPC5 4039 0.0e+00 Otoferlin OS=Danio rerio GN=otof PE=3 SV=1 PF00168//PF00957//PF08150 C2 domain//Synaptobrevin//FerB (NUC096) domain GO:0016192 vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG1326 Membrane-associated protein FER-1 and related ferlins, contain multiple C2 domains Cluster-8309.40965 BP_3 60.01 0.93 3413 332375404 AEE62843.1 1194 7.8e-128 unknown [Dendroctonus ponderosae] 642934692 XM_008199551.1 353 0 PREDICTED: Tribolium castaneum CUGBP Elav-like family member 1 (LOC660275), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q9IBD0 376 2.3e-34 CUGBP Elav-like family member 1 OS=Danio rerio GN=celf1 PE=1 SV=1 PF08675//PF00076//PF16367 RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.40966 BP_3 191.55 4.69 2259 332375404 AEE62843.1 1194 5.2e-128 unknown [Dendroctonus ponderosae] 817215516 XM_012428466.1 65 7.49972e-23 PREDICTED: Orussus abietinus CUGBP Elav-like family member 4 (LOC105701602), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q9IBD0 376 1.5e-34 CUGBP Elav-like family member 1 OS=Danio rerio GN=celf1 PE=1 SV=1 PF08675//PF00076//PF16367 RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0004535//GO:0003676//GO:0046872 RNA binding//poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.40967 BP_3 533.64 14.74 2037 642928504 XP_008193818.1 2050 2.6e-227 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2K6 941 4.2e-100 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.40968 BP_3 708.00 6.08 5902 642937173 XP_008198722.1 3541 0.0e+00 PREDICTED: myosin-11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYY4 139 1.2e-06 Uveal autoantigen with coiled-coil domains and ankyrin repeats protein OS=Bos taurus GN=UACA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40969 BP_3 508.39 3.66 6985 642920223 XP_975548.2 2830 0.0e+00 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 604 1.7e-60 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF01180//PF00170//PF02183 Dihydroorotate dehydrogenase//bZIP transcription factor//Homeobox associated leucine zipper GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0016627//GO:0003700//GO:0043565 oxidoreductase activity, acting on the CH-CH group of donors//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex -- -- Cluster-8309.40970 BP_3 393.60 6.19 3356 270011492 EFA07940.1 3322 0.0e+00 hypothetical protein TcasGA2_TC005521 [Tribolium castaneum] 759067243 XM_011344784.1 294 5.6042e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 6.8e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF07533//PF13185//PF13492//PF01590//PF00233 BRK domain//GAF domain//GAF domain//GAF domain//3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0005515//GO:0016817//GO:0004114 protein binding//hydrolase activity, acting on acid anhydrides//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.40971 BP_3 24.75 0.69 2020 573896974 XP_006636225.1 150 5.3e-07 PREDICTED: tissue factor pathway inhibitor 2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- C0HJF3 141 2.4e-07 Analgesic polypeptide HC3 OS=Heteractis crispa PE=1 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.40973 BP_3 80.01 0.50 8077 642916295 XP_008190964.1 6190 0.0e+00 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X2 [Tribolium castaneum] 642916294 XM_008192742.1 790 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 1 (LOC663739), transcript variant X2, mRNA K12604 CNOT1, NOT1 CCR4-NOT transcription complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12604 Q6ZQ08 3666 0.0e+00 CCR4-NOT transcription complex subunit 1 OS=Mus musculus GN=Cnot1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1831 Negative regulator of transcription Cluster-8309.40974 BP_3 78.34 0.46 8571 546674242 ERL85667.1 1294 5.0e-139 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q9VHN9 477 1.1e-45 Hermansky-Pudlak syndrome 5 protein homolog OS=Drosophila melanogaster GN=p PE=2 SV=1 PF13639//PF12678 Ring finger domain//RING-H2 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.40975 BP_3 738.95 4.84 7645 546674242 ERL85667.1 1294 4.4e-139 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q6DD32 735 1.2e-75 RING finger protein 121 OS=Xenopus laevis GN=rnf121 PE=2 SV=1 PF00097//PF12678//PF17123//PF14634//PF09773//PF12861//PF13639//PF07967 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain//Meckelin (Transmembrane protein 67)//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//C3HC zinc finger-like GO:0016567//GO:0010826//GO:0042384 protein ubiquitination//negative regulation of centrosome duplication//cilium assembly GO:0005515//GO:0004842//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//metal ion binding//zinc ion binding GO:0005680//GO:0005634//GO:0036038 anaphase-promoting complex//nucleus//TCTN-B9D complex KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.40977 BP_3 395.38 12.20 1854 642918280 XP_008191442.1 1219 5.4e-131 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 642918281 XM_008193221.1 276 3.11522e-140 PREDICTED: Tribolium castaneum UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (LOC655930), transcript variant X2, mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 1102 8.1e-119 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13176//PF13414//PF02259//PF13374//PF00515//PF13371//PF13174//PF07721//PF13181 Tetratricopeptide repeat//TPR repeat//FAT domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.40979 BP_3 2889.47 16.42 8775 642934775 XP_008197803.1 5779 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 436 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 3079 0.0e+00 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.40981 BP_3 120.51 4.88 1482 642933447 XP_008197423.1 572 4.5e-56 PREDICTED: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 P18155 404 5.6e-38 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Mus musculus GN=Mthfd2 PE=1 SV=1 PF00763//PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.40982 BP_3 100.35 0.50 10043 642912633 XP_008200941.1 4778 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q5H8C4 2035 2.9e-226 Vacuolar protein sorting-associated protein 13A OS=Mus musculus GN=Vps13a PE=2 SV=1 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.40984 BP_3 37.19 0.31 6168 546670634 ERL83320.1 5541 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.5498e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 P35125 1367 5.1e-149 Ubiquitin carboxyl-terminal hydrolase 6 OS=Homo sapiens GN=USP6 PE=1 SV=2 PF13499//PF05191//PF00036//PF13405//PF06337//PF11421//PF00443 EF-hand domain pair//Adenylate kinase, active site lid//EF hand//EF-hand domain//DUSP domain//ATP synthase F1 beta subunit//Ubiquitin carboxyl-terminal hydrolase GO:0006144//GO:0046034//GO:0006508//GO:0016579//GO:0006754 purine nucleobase metabolic process//ATP metabolic process//proteolysis//protein deubiquitination//ATP biosynthetic process GO:0004843//GO:0036459//GO:0005524//GO:0016887//GO:0005509//GO:0004017 ubiquitin-specific protease activity//ubiquitinyl hydrolase activity//ATP binding//ATPase activity//calcium ion binding//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.40987 BP_3 162.89 1.70 4903 642938005 XP_008199168.1 1258 4.3e-135 PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like isoform X2 [Tribolium castaneum]>gi|270015674|gb|EFA12122.1| hypothetical protein TcasGA2_TC002268 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 P59644 534 1.6e-52 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Mus musculus GN=Inpp5j PE=2 SV=2 PF06330 Trichodiene synthase (TRI5) GO:0016106//GO:0046854//GO:0016114 sesquiterpenoid biosynthetic process//phosphatidylinositol phosphorylation//terpenoid biosynthetic process GO:0045482 trichodiene synthase activity -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.40988 BP_3 37.93 0.33 5894 642932082 XP_008196850.1 2434 2.2e-271 PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 Q02978 797 6.0e-83 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Homo sapiens GN=SLC25A11 PE=1 SV=3 PF13465//PF00096//PF08465//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Thymidine kinase from Herpesvirus C-terminal//C2H2-type zinc finger GO:0006206//GO:0006230 pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0004797//GO:0005524//GO:0046872 thymidine kinase activity//ATP binding//metal ion binding -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.40989 BP_3 1615.64 13.94 5878 642932082 XP_008196850.1 2434 2.2e-271 PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 1037 8.9e-111 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 PF00096//PF13465//PF08465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Thymidine kinase from Herpesvirus C-terminal//C2H2-type zinc finger GO:0006206//GO:0006230 pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0046872//GO:0005524//GO:0004797 metal ion binding//ATP binding//thymidine kinase activity -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.4099 BP_3 22.37 0.34 3453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40990 BP_3 3648.19 29.47 6258 642916856 XP_968783.3 1187 9.3e-127 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] 242023932 XM_002432340.1 66 5.82909e-23 Pediculus humanus corporis proteasome subunit beta type, putative, mRNA K02732 PSMB1 20S proteasome subunit beta 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02732 P40304 767 1.9e-79 Proteasome subunit beta type-1 OS=Drosophila melanogaster GN=Prosbeta6 PE=2 SV=2 PF13673//PF00096//PF00227//PF13413//PF04988//PF01381//PF12844//PF13912 Acetyltransferase (GNAT) domain//Zinc finger, C2H2 type//Proteasome subunit//Helix-turn-helix domain//A-kinase anchoring protein 95 (AKAP95)//Helix-turn-helix//Helix-turn-helix domain//C2H2-type zinc finger GO:0051603//GO:0042967 proteolysis involved in cellular protein catabolic process//acyl-carrier-protein biosynthetic process GO:0004298//GO:0046872//GO:0043565//GO:0008080//GO:0003677 threonine-type endopeptidase activity//metal ion binding//sequence-specific DNA binding//N-acetyltransferase activity//DNA binding GO:0005839//GO:0005634 proteasome core complex//nucleus KOG0179 20S proteasome, regulatory subunit beta type PSMB1/PRE7 Cluster-8309.40991 BP_3 14.78 1.28 847 270003047 EEZ99494.1 199 4.6e-13 hypothetical protein TcasGA2_TC000070 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40992 BP_3 11.00 9.80 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40993 BP_3 45.56 3.36 945 642932847 XP_008197010.1 466 5.7e-44 PREDICTED: NAD kinase-like isoform X2 [Tribolium castaneum] 751793735 XM_011208255.1 87 1.81064e-35 PREDICTED: Bactrocera dorsalis NAD kinase (LOC105228428), transcript variant X3, mRNA K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 O95544 294 2.0e-25 NAD kinase OS=Homo sapiens GN=NADK PE=1 SV=1 PF01513//PF01017 ATP-NAD kinase//STAT protein, all-alpha domain GO:0007165//GO:0008152//GO:0046497//GO:0006355//GO:0006741//GO:0006769 signal transduction//metabolic process//nicotinate nucleotide metabolic process//regulation of transcription, DNA-templated//NADP biosynthetic process//nicotinamide metabolic process GO:0003951//GO:0004871//GO:0003700 NAD+ kinase activity//signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2178 Predicted sugar kinase Cluster-8309.40994 BP_3 189.85 2.56 3869 642932845 XP_008197009.1 1536 2.0e-167 PREDICTED: NAD kinase-like isoform X1 [Tribolium castaneum] 751793735 XM_011208255.1 75 3.56733e-28 PREDICTED: Bactrocera dorsalis NAD kinase (LOC105228428), transcript variant X3, mRNA K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 P58058 997 2.5e-106 NAD kinase OS=Mus musculus GN=Nadk PE=1 SV=2 PF01513//PF00781 ATP-NAD kinase//Diacylglycerol kinase catalytic domain GO:0006741//GO:0008152//GO:0046497//GO:0006769 NADP biosynthetic process//metabolic process//nicotinate nucleotide metabolic process//nicotinamide metabolic process GO:0016301//GO:0003951 kinase activity//NAD+ kinase activity -- -- KOG2178 Predicted sugar kinase Cluster-8309.40995 BP_3 1901.84 8.65 10893 642918112 XP_008194047.1 2422 1.0e-269 PREDICTED: calpain-B isoform X2 [Tribolium castaneum] 751219340 XM_011164448.1 186 1.99424e-89 PREDICTED: Solenopsis invicta calpain-A-like (LOC105197860), transcript variant X10, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 1916 2.0e-212 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF13499//PF13405//PF13833//PF00036//PF12763//PF13202//PF00648 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand//Calpain family cysteine protease GO:0006508 proteolysis GO:0005509//GO:0005515//GO:0004198 calcium ion binding//protein binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.40996 BP_3 46.51 0.34 6840 270002551 EEZ98998.1 3806 0.0e+00 hypothetical protein TcasGA2_TC004859 [Tribolium castaneum] 827549416 XM_004927285.2 162 2.74369e-76 PREDICTED: Bombyx mori tankyrase (LOC101740141), mRNA K10799 TNKS tankyrase http://www.genome.jp/dbget-bin/www_bget?ko:K10799 Q9VBP3 3110 0.0e+00 Tankyrase OS=Drosophila melanogaster GN=Tnks PE=1 SV=1 PF00023//PF00322//PF13606//PF00536//PF00644//PF07647 Ankyrin repeat//Endothelin family//Ankyrin repeat//SAM domain (Sterile alpha motif)//Poly(ADP-ribose) polymerase catalytic domain//SAM domain (Sterile alpha motif) GO:0019229 regulation of vasoconstriction GO:0005515//GO:0003950 protein binding//NAD+ ADP-ribosyltransferase activity GO:0005576 extracellular region -- -- Cluster-8309.40997 BP_3 2696.43 103.87 1543 270011004 EFA07452.1 827 1.3e-85 serine protease P91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 496 1.3e-48 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40999 BP_3 910.00 23.55 2154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41 BP_3 1.00 3.59 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41001 BP_3 666.20 37.81 1141 91087251 XP_975522.1 560 8.6e-55 PREDICTED: uncharacterized protein LOC664422 [Tribolium castaneum]>gi|270009553|gb|EFA06001.1| hypothetical protein TcasGA2_TC008827 [Tribolium castaneum] -- -- -- -- -- K04402 GADD45 growth arrest and DNA-damage-inducible protein http://www.genome.jp/dbget-bin/www_bget?ko:K04402 Q2KIX1 132 1.5e-06 Growth arrest and DNA damage-inducible protein GADD45 gamma OS=Bos taurus GN=GADD45G PE=2 SV=1 PF05733 Tenuivirus/Phlebovirus nucleocapsid protein GO:0051726//GO:0006950 regulation of cell cycle//response to stress GO:0003723 RNA binding GO:0005634//GO:0019013 nucleus//viral nucleocapsid -- -- Cluster-8309.41002 BP_3 35.82 0.93 2143 91080995 XP_975051.1 1754 5.7e-193 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 731415861 XM_010661396.1 41 1.56066e-09 PREDICTED: Vitis vinifera calreticulin (LOC100256319), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P35565 1297 2.3e-141 Calnexin OS=Rattus norvegicus GN=Canx PE=1 SV=1 PF00262 Calreticulin family GO:0006457 protein folding GO:0051082//GO:0005509 unfolded protein binding//calcium ion binding GO:0005783 endoplasmic reticulum KOG0675 Calnexin Cluster-8309.41004 BP_3 69.87 0.78 4604 642915302 XP_008190562.1 1416 1.9e-153 PREDICTED: JNK-interacting protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04436 MAPK8IP3, JIP3 mitogen-activated protein kinase 8 interacting protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04436 O60271 993 8.8e-106 C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens GN=SPAG9 PE=1 SV=4 PF03178 CPSF A subunit region -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.41007 BP_3 99419.40 1667.76 3165 642930326 XP_008196348.1 273 4.5e-21 PREDICTED: neurofilament heavy polypeptide-like [Tribolium castaneum]>gi|270010711|gb|EFA07159.1| hypothetical protein TcasGA2_TC010154 [Tribolium castaneum] 642930325 XM_008198126.1 37 3.87519e-07 PREDICTED: Tribolium castaneum neurofilament heavy polypeptide-like (LOC661849), mRNA -- -- -- -- -- -- -- -- PF06610 L-alanine exporter -- -- GO:0034639 L-amino acid efflux transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.41008 BP_3 782.88 45.89 1114 478256566 ENN76750.1 510 5.3e-49 hypothetical protein YQE_06815, partial [Dendroctonus ponderosae]>gi|546680028|gb|ERL90390.1| hypothetical protein D910_07739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05793//PF09726//PF07393//PF01101 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Transmembrane protein//Exocyst complex component Sec10//HMG14 and HMG17 GO:0006367//GO:0048278//GO:0006887//GO:0032968 transcription initiation from RNA polymerase II promoter//vesicle docking//exocytosis//positive regulation of transcription elongation from RNA polymerase II promoter GO:0031492//GO:0003677 nucleosomal DNA binding//DNA binding GO:0005737//GO:0005634//GO:0000785//GO:0016021 cytoplasm//nucleus//chromatin//integral component of membrane -- -- Cluster-8309.41009 BP_3 32.48 0.66 2671 478251961 ENN72399.1 1768 1.7e-194 hypothetical protein YQE_11033, partial [Dendroctonus ponderosae] -- -- -- -- -- K01412 PMPCA, MAS2 mitochondrial-processing peptidase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01412 Q0P5M8 1040 1.8e-111 Mitochondrial-processing peptidase subunit alpha OS=Bos taurus GN=PMPCA PE=2 SV=1 PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- KOG2067 Mitochondrial processing peptidase, alpha subunit Cluster-8309.41010 BP_3 41.11 3.26 899 642930465 XP_974795.3 960 2.8e-101 PREDICTED: protein YIF1B [Tribolium castaneum]>gi|270010732|gb|EFA07180.1| hypothetical protein TcasGA2_TC010181 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P301 649 1.3e-66 Protein YIF1B OS=Xenopus tropicalis GN=yif1b PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG3094 Predicted membrane protein Cluster-8309.41011 BP_3 26.56 1.17 1388 478260464 ENN80184.1 1184 4.6e-127 hypothetical protein YQE_03380, partial [Dendroctonus ponderosae]>gi|546674446|gb|ERL85820.1| hypothetical protein D910_03235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P301 681 4.0e-70 Protein YIF1B OS=Xenopus tropicalis GN=yif1b PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG3094 Predicted membrane protein Cluster-8309.41012 BP_3 1.00 11.75 239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41014 BP_3 52.67 1.59 1885 642920515 XP_008192382.1 1537 7.3e-168 PREDICTED: TWiK family of potassium channels protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 367 1.4e-33 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF07830//PF00520//PF01007 Protein serine/threonine phosphatase 2C, C-terminal domain//Ion transport protein//Inward rectifier potassium channel GO:0006813//GO:0006470//GO:0055085//GO:0006811 potassium ion transport//protein dephosphorylation//transmembrane transport//ion transport GO:0005242//GO:0030145//GO:0004721//GO:0000287//GO:0005216 inward rectifier potassium channel activity//manganese ion binding//phosphoprotein phosphatase activity//magnesium ion binding//ion channel activity GO:0016021//GO:0008076//GO:0016020 integral component of membrane//voltage-gated potassium channel complex//membrane -- -- Cluster-8309.41016 BP_3 7.59 0.39 1241 642917126 XP_008191126.1 603 9.6e-60 PREDICTED: uncharacterized protein LOC659233 [Tribolium castaneum]>gi|270003488|gb|EEZ99935.1| hypothetical protein TcasGA2_TC002731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41017 BP_3 622.35 5.27 5985 642929257 XP_008195757.1 2695 1.2e-301 PREDICTED: enhancer of polycomb homolog 1 [Tribolium castaneum] 642929256 XM_008197535.1 558 0 PREDICTED: Tribolium castaneum enhancer of polycomb homolog 1 (LOC103313670), mRNA K11322 EPC enhancer of polycomb-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11322 Q8C9X6 1053 1.3e-112 Enhancer of polycomb homolog 1 OS=Mus musculus GN=Epc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2261 Polycomb enhancer protein, EPC Cluster-8309.41020 BP_3 73.26 0.98 3897 642928441 XP_008193786.1 225 2.1e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41021 BP_3 152.13 0.89 8569 478253260 ENN73631.1 10407 0.0e+00 hypothetical protein YQE_09878, partial [Dendroctonus ponderosae] 751798243 XM_011210726.1 68 6.18013e-24 PREDICTED: Bactrocera dorsalis protein furry-like (LOC105230123), mRNA -- -- -- -- O94915 4680 0.0e+00 Protein furry homolog-like OS=Homo sapiens GN=FRYL PE=1 SV=2 PF05510//PF02140//PF09201 Sarcoglycan alpha/epsilon//Galactose binding lectin domain//SRX, signal recognition particle receptor alpha subunit -- -- GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0016012 sarcoglycan complex KOG1825 Fry-like conserved proteins Cluster-8309.41022 BP_3 518.00 9.25 2992 642931889 XP_008196769.1 3735 0.0e+00 PREDICTED: protein HID1 [Tribolium castaneum]>gi|270012240|gb|EFA08688.1| hypothetical protein TcasGA2_TC006359 [Tribolium castaneum] 755988842 XM_011313686.1 188 4.19909e-91 PREDICTED: Fopius arisanus protein HID1 (LOC105271879), mRNA -- -- -- -- Q8R1F6 2846 0.0e+00 Protein HID1 OS=Mus musculus GN=Hid1 PE=1 SV=1 PF02291 Transcription initiation factor IID, 31kD subunit GO:0006352 DNA-templated transcription, initiation -- -- -- -- KOG2226 Proteins containing regions of low-complexity Cluster-8309.41023 BP_3 20.03 0.45 2424 642913085 XP_008201384.1 581 6.7e-57 PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum]>gi|642913087|ref|XP_008201386.1| PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum] 642913086 XM_008203164.1 219 1.98609e-108 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X9, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 314 2.5e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.41025 BP_3 66.13 1.16 3040 546678022 ERL88746.1 1049 4.5e-111 hypothetical protein D910_06128 [Dendroctonus ponderosae] -- -- -- -- -- K01784 galE, GALE UDP-glucose 4-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01784 Q9W0P5 742 7.4e-77 UDP-glucose 4-epimerase OS=Drosophila melanogaster GN=Gale PE=1 SV=1 PF01073//PF00106//PF03435//PF01370//PF02254 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family//TrkA-N domain GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008152//GO:0008210//GO:0006813 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//metabolic process//estrogen metabolic process//potassium ion transport GO:0003854//GO:0050662//GO:0003824//GO:0016616//GO:0016491 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase Cluster-8309.41028 BP_3 898.27 5.32 8426 270002439 EEZ98886.1 1242 5.3e-133 hypothetical protein TcasGA2_TC004501 [Tribolium castaneum] 642912470 XM_008202654.1 112 2.10956e-48 PREDICTED: Tribolium castaneum transcription elongation regulator 1 (LOC659146), transcript variant X2, mRNA K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 601 4.6e-60 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF00397//PF12905//PF08503//PF10018 WW domain//Endo-alpha-N-acetylgalactosaminidase//Tetrahydrodipicolinate succinyltransferase N-terminal//Vitamin-D-receptor interacting Mediator subunit 4 GO:0042967//GO:0006531//GO:0006522//GO:0006357 acyl-carrier-protein biosynthetic process//aspartate metabolic process//alanine metabolic process//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0033926//GO:0001104//GO:0047200 protein binding//glycopeptide alpha-N-acetylgalactosaminidase activity//RNA polymerase II transcription cofactor activity//tetrahydrodipicolinate N-acetyltransferase activity GO:0016592 mediator complex KOG0155 Transcription factor CA150 Cluster-8309.41029 BP_3 231.80 8.69 1577 270002439 EEZ98886.1 272 3.0e-21 hypothetical protein TcasGA2_TC004501 [Tribolium castaneum] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 135 9.3e-07 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862 DDHD domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.41030 BP_3 91.00 1.93 2563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05083 LST-1 protein GO:0000902//GO:0006955 cell morphogenesis//immune response -- -- GO:0016020 membrane -- -- Cluster-8309.41033 BP_3 144.33 0.58 12263 270001010 EEZ97457.1 2072 4.4e-229 hypothetical protein TcasGA2_TC011288 [Tribolium castaneum] 662203988 XM_008477133.1 151 6.4237e-70 PREDICTED: Diaphorina citri calcium-activated potassium channel slowpoke-like (LOC103512372), mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1831 1.6e-202 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF12905//PF00397 Endo-alpha-N-acetylgalactosaminidase//WW domain -- -- GO:0005515//GO:0033926 protein binding//glycopeptide alpha-N-acetylgalactosaminidase activity -- -- KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.41035 BP_3 2096.46 28.88 3790 478258223 ENN78352.1 1166 1.5e-124 hypothetical protein YQE_05154, partial [Dendroctonus ponderosae] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q28FD1 632 5.3e-64 Alcohol dehydrogenase [NADP(+)] OS=Xenopus tropicalis GN=akr1a1 PE=2 SV=1 PF04869 Uso1 / p115 like vesicle tethering protein, head region GO:0048280//GO:0006886 vesicle fusion with Golgi apparatus//intracellular protein transport -- -- GO:0000139//GO:0005737 Golgi membrane//cytoplasm KOG1577 Aldo/keto reductase family proteins Cluster-8309.41036 BP_3 2164.05 9.70 11045 546681959 ERL91955.1 571 4.4e-55 hypothetical protein D910_09278, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04443 Acyl-protein synthetase, LuxE GO:0008218 bioluminescence GO:0047474 long-chain fatty acid luciferin component ligase activity -- -- -- -- Cluster-8309.41037 BP_3 711.45 28.93 1477 642917156 XP_008191141.1 1740 1.7e-191 PREDICTED: filamin-A [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 215 4.6e-16 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41038 BP_3 777.66 8.59 4657 546681405 ERL91502.1 4308 0.0e+00 hypothetical protein D910_08832 [Dendroctonus ponderosae] 768409434 XM_011554491.1 152 6.75268e-71 PREDICTED: Plutella xylostella filamin-A-like (LOC105384276), mRNA K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q8BTM8 542 1.8e-53 Filamin-A OS=Mus musculus GN=Flna PE=1 SV=5 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.41039 BP_3 721.85 7.02 5245 642932814 XP_008196996.1 2812 0.0e+00 PREDICTED: protein CLEC16A isoform X4 [Tribolium castaneum] -- -- -- -- -- K19513 CLEC16A protein CLEC16A http://www.genome.jp/dbget-bin/www_bget?ko:K19513 Q2KHT3 1236 6.7e-134 Protein CLEC16A OS=Homo sapiens GN=CLEC16A PE=2 SV=2 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG2219 Uncharacterized conserved protein Cluster-8309.41040 BP_3 353.38 1.58 11098 270003480 EEZ99927.1 4552 0.0e+00 hypothetical protein TcasGA2_TC002723 [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q8VHX6 482 3.8e-46 Filamin-C OS=Mus musculus GN=Flnc PE=1 SV=3 PF03554//PF05653//PF03110//PF03547 UL73 viral envelope glycoprotein//Magnesium transporter NIPA//SBP domain//Membrane transport protein GO:0015693//GO:0055085 magnesium ion transport//transmembrane transport GO:0003677//GO:0015095 DNA binding//magnesium ion transmembrane transporter activity GO:0005634//GO:0016021//GO:0019031 nucleus//integral component of membrane//viral envelope KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.41042 BP_3 681.09 12.12 3001 641652894 XP_008178577.1 157 1.2e-07 PREDICTED: uncharacterized protein DDB_G0283697-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.41044 BP_3 1244.98 51.15 1465 478258513 ENN78588.1 1533 1.6e-167 hypothetical protein YQE_04955, partial [Dendroctonus ponderosae] 817195914 XM_012418095.1 263 4.12717e-133 PREDICTED: Orussus abietinus cAMP-dependent protein kinase type I regulatory subunit (LOC105695993), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P16905 1375 1.4e-150 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.41045 BP_3 19.73 0.41 2625 270010218 EFA06666.1 1339 9.2e-145 hypothetical protein TcasGA2_TC009593, partial [Tribolium castaneum] 674034499 XM_008840881.1 44 4.12141e-11 PREDICTED: Nannospalax galili solute carrier family 27 (fatty acid transporter), member 6 (Slc27a6), mRNA K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K08745 Q60714 1013 2.4e-108 Long-chain fatty acid transport protein 1 OS=Mus musculus GN=Slc27a1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.41046 BP_3 24.53 0.87 1650 642928984 XP_008195645.1 1519 7.8e-166 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q6UWM7 1099 1.6e-118 Lactase-like protein OS=Homo sapiens GN=LCTL PE=1 SV=2 PF02226//PF00232 Picornavirus coat protein (VP4)//Glycosyl hydrolase family 1 GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0004553//GO:0016798//GO:0005198 hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity, acting on glycosyl bonds//structural molecule activity GO:0019028 viral capsid KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.41048 BP_3 1128.97 4.33 12845 270007509 EFA03957.1 1887 1.3e-207 hypothetical protein TcasGA2_TC014101 [Tribolium castaneum] 332374221 BT127290.1 481 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 733 3.5e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF01522//PF01607//PF00642//PF02198 MMPL family//Polysaccharide deacetylase//Chitin binding Peritrophin-A domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Sterile alpha motif (SAM)/Pointed domain GO:0006030//GO:0006807//GO:0005975 chitin metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process GO:0043565//GO:0016810//GO:0008061//GO:0046872 sequence-specific DNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding//metal ion binding GO:0005634//GO:0005576//GO:0016020 nucleus//extracellular region//membrane -- -- Cluster-8309.41049 BP_3 1195.00 193.07 590 260794194 XP_002592094.1 158 1.8e-08 hypothetical protein BRAFLDRAFT_84963 [Branchiostoma floridae]>gi|229277309|gb|EEN48105.1| hypothetical protein BRAFLDRAFT_84963 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4105 BP_3 2.00 0.37 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41050 BP_3 692.28 3.54 9729 282392017 NP_001164152.1 854 5.9e-88 held out wings [Tribolium castaneum] 645014013 XM_008207131.1 156 8.46115e-73 PREDICTED: Nasonia vitripennis protein held out wings (LOC100120734), mRNA K14945 QKI protein quaking http://www.genome.jp/dbget-bin/www_bget?ko:K14945 O01367 770 1.3e-79 Protein held out wings OS=Drosophila melanogaster GN=how PE=1 SV=1 PF13103//PF00013//PF13014 TonB C terminal//KH domain//KH domain GO:0006810 transport GO:0003723 RNA binding -- -- KOG1588 RNA-binding protein Sam68 and related KH domain proteins Cluster-8309.41051 BP_3 29.53 0.57 2778 91086165 XP_970259.1 1883 8.1e-208 PREDICTED: ATP-dependent zinc metalloprotease YME1 homolog [Tribolium castaneum]>gi|270009883|gb|EFA06331.1| hypothetical protein TcasGA2_TC009202 [Tribolium castaneum] 759074133 XM_011348443.1 83 9.11373e-33 PREDICTED: Cerapachys biroi ATP-dependent zinc metalloprotease YME1 homolog (LOC105284713), transcript variant X3, mRNA K08955 YME1 ATP-dependent metalloprotease http://www.genome.jp/dbget-bin/www_bget?ko:K08955 P54813 1316 1.9e-143 ATP-dependent zinc metalloprotease YME1 homolog OS=Caenorhabditis elegans GN=ymel-1 PE=3 SV=2 PF10415//PF00004//PF01434 Fumarase C C-terminus//ATPase family associated with various cellular activities (AAA)//Peptidase family M41 GO:0030163//GO:0006099//GO:0006508 protein catabolic process//tricarboxylic acid cycle//proteolysis GO:0016829//GO:0017111//GO:0005524//GO:0004222 lyase activity//nucleoside-triphosphatase activity//ATP binding//metalloendopeptidase activity GO:0016020 membrane KOG0734 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.41052 BP_3 176.00 19.49 727 91085625 XP_966506.1 157 2.9e-08 PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|642927073|ref|XP_008195125.1| PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|642927076|ref|XP_008195126.1| PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0007186//GO:0006950 G-protein coupled receptor signaling pathway//response to stress GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.41054 BP_3 715.77 291.43 409 821003176 XP_012365190.1 667 1.2e-67 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 56199551 AY752852.1 183 3.2176e-89 Culicoides sonorensis clone CsUB1 ubiquitin mRNA, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 667 5.0e-69 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF04452//PF00240//PF14560 RNA methyltransferase//Ubiquitin family//Ubiquitin-like domain GO:0006364 rRNA processing GO:0005515//GO:0008168 protein binding//methyltransferase activity -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.41059 BP_3 306.62 7.42 2284 642911463 XP_008199434.1 611 2.1e-60 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06872 EspG protein GO:0009405//GO:0006508 pathogenesis//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.41060 BP_3 79.19 0.42 9374 642914109 XP_008201547.1 4088 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12923 427 7.7e-40 Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2 PF08997//PF00595//PF13180//PF02873 Ubiquinol-cytochrome C reductase complex, 6.4kD protein//PDZ domain (Also known as DHR or GLGF)//PDZ domain//UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain GO:0006119//GO:0006040//GO:0015992//GO:0055114//GO:0006118 oxidative phosphorylation//amino sugar metabolic process//proton transport//oxidation-reduction process//obsolete electron transport GO:0008121//GO:0005515//GO:0008762//GO:0009055 ubiquinol-cytochrome-c reductase activity//protein binding//UDP-N-acetylmuramate dehydrogenase activity//electron carrier activity -- -- -- -- Cluster-8309.41061 BP_3 19.47 0.64 1756 655892731 XP_008248987.1 404 1.6e-36 PREDICTED: zinc finger protein 699 [Oryctolagus cuniculus]>gi|655892733|ref|XP_008248988.1| PREDICTED: zinc finger protein 699 [Oryctolagus cuniculus]>gi|655892735|ref|XP_008248989.1| PREDICTED: zinc finger protein 699 [Oryctolagus cuniculus] 533131911 XM_005380929.1 41 1.27414e-09 PREDICTED: Chinchilla lanigera zinc finger protein 133 (Znf133), transcript variant X9, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q32M78 398 3.3e-37 Zinc finger protein 699 OS=Homo sapiens GN=ZNF699 PE=1 SV=1 PF13912//PF05191//PF16622//PF01844//PF06689//PF13465//PF17123//PF16866//PF01780//PF00096 C2H2-type zinc finger//Adenylate kinase, active site lid//zinc-finger C2H2-type//HNH endonuclease//ClpX C4-type zinc finger//Zinc-finger double domain//RING-like zinc finger//PHD-finger//Ribosomal L37ae protein family//Zinc finger, C2H2 type GO:0006412//GO:0046034//GO:0006144//GO:0042254 translation//ATP metabolic process//purine nucleobase metabolic process//ribosome biogenesis GO:0004519//GO:0005515//GO:0046983//GO:0003676//GO:0008270//GO:0003735//GO:0046872//GO:0004017 endonuclease activity//protein binding//protein dimerization activity//nucleic acid binding//zinc ion binding//structural constituent of ribosome//metal ion binding//adenylate kinase activity GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.41062 BP_3 4.02 0.34 855 270003817 EFA00265.1 166 3.1e-09 hypothetical protein TcasGA2_TC003098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF13912//PF00643//PF02701//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//B-box zinc finger//Dof domain, zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005622 intracellular KOG1721 FOG: Zn-finger Cluster-8309.41063 BP_3 1.36 0.67 388 478256542 ENN76726.1 149 1.3e-07 hypothetical protein YQE_06791, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.41064 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41065 BP_3 555.54 4.79 5878 270004589 EFA01037.1 1102 6.3e-117 hypothetical protein TcasGA2_TC003953 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U3I9 177 4.7e-11 Zinc finger protein 865 OS=Mus musculus GN=Znf865 PE=2 SV=1 PF01420//PF13465//PF01544//PF00096//PF00688//PF13912//PF09668 Type I restriction modification DNA specificity domain//Zinc-finger double domain//CorA-like Mg2+ transporter protein//Zinc finger, C2H2 type//TGF-beta propeptide//C2H2-type zinc finger//Aspartyl protease GO:0040007//GO:0030001//GO:0007165//GO:0055085//GO:0008283//GO:0006508//GO:0006304 growth//metal ion transport//signal transduction//transmembrane transport//cell proliferation//proteolysis//DNA modification GO:0008083//GO:0004190//GO:0003677//GO:0046873//GO:0046872 growth factor activity//aspartic-type endopeptidase activity//DNA binding//metal ion transmembrane transporter activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.41067 BP_3 1397.33 9.36 7490 478256535 ENN76719.1 1038 2.1e-109 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 683942502 XM_009101103.1 36 3.31879e-06 PREDICTED: Serinus canaria zinc finger protein 329-like (LOC103825865), partial mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 629 2.3e-63 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF07975//PF12142//PF13465//PF16622//PF05191//PF01428//PF13912//PF04810//PF00130//PF01155//PF06397//PF00096//PF07776//PF04889 TFIIH C1-like domain//Polyphenol oxidase middle domain//Zinc-finger double domain//zinc-finger C2H2-type//Adenylate kinase, active site lid//AN1-like Zinc finger//C2H2-type zinc finger//Sec23/Sec24 zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Desulfoferrodoxin, N-terminal domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Cwf15/Cwc15 cell cycle control protein GO:0046034//GO:0006570//GO:0006281//GO:0006886//GO:0006464//GO:0055114//GO:0035556//GO:0000398//GO:0006118//GO:0006144//GO:0006888 ATP metabolic process//tyrosine metabolic process//DNA repair//intracellular protein transport//cellular protein modification process//oxidation-reduction process//intracellular signal transduction//mRNA splicing, via spliceosome//obsolete electron transport//purine nucleobase metabolic process//ER to Golgi vesicle-mediated transport GO:0004097//GO:0005506//GO:0004017//GO:0008270//GO:0016151//GO:0046872 catechol oxidase activity//iron ion binding//adenylate kinase activity//zinc ion binding//nickel cation binding//metal ion binding GO:0030127//GO:0005681//GO:0005634 COPII vesicle coat//spliceosomal complex//nucleus -- -- Cluster-8309.41070 BP_3 75.08 2.12 2002 91076704 XP_972106.1 1365 6.8e-148 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 2.1e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF10147//PF00892//PF04142//PF08449 Growth arrest and DNA-damage-inducible proteins-interacting protein 1//EamA-like transporter family//Nucleotide-sugar transporter//UAA transporter family GO:0055085//GO:0008643//GO:0015780//GO:0007049 transmembrane transport//carbohydrate transport//nucleotide-sugar transport//cell cycle GO:0005351//GO:0005338 sugar:proton symporter activity//nucleotide-sugar transmembrane transporter activity GO:0005634//GO:0016021//GO:0016020//GO:0000139 nucleus//integral component of membrane//membrane//Golgi membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.41071 BP_3 14.36 0.38 2134 91076704 XP_972106.1 1203 4.4e-129 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 O77592 664 5.8e-68 UDP-N-acetylglucosamine transporter OS=Canis familiaris GN=SLC35A3 PE=2 SV=1 PF00892//PF04142//PF08449 EamA-like transporter family//Nucleotide-sugar transporter//UAA transporter family GO:0055085//GO:0015780//GO:0008643 transmembrane transport//nucleotide-sugar transport//carbohydrate transport GO:0005351//GO:0005338 sugar:proton symporter activity//nucleotide-sugar transmembrane transporter activity GO:0016021//GO:0000139//GO:0016020 integral component of membrane//Golgi membrane//membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.41072 BP_3 60.05 0.45 6786 91076704 XP_972106.1 1365 2.3e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 7.2e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF01297//PF00175//PF00892//PF13371//PF08449//PF08030//PF04142//PF10147 Zinc-uptake complex component A periplasmic//Oxidoreductase NAD-binding domain//EamA-like transporter family//Tetratricopeptide repeat//UAA transporter family//Ferric reductase NAD binding domain//Nucleotide-sugar transporter//Growth arrest and DNA-damage-inducible proteins-interacting protein 1 GO:0030001//GO:0055085//GO:0007049//GO:0015780//GO:0055114//GO:0008643 metal ion transport//transmembrane transport//cell cycle//nucleotide-sugar transport//oxidation-reduction process//carbohydrate transport GO:0016491//GO:0005515//GO:0005351//GO:0005338//GO:0046872 oxidoreductase activity//protein binding//sugar:proton symporter activity//nucleotide-sugar transmembrane transporter activity//metal ion binding GO:0005634//GO:0016021//GO:0000139//GO:0016020 nucleus//integral component of membrane//Golgi membrane//membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.41073 BP_3 576.22 17.14 1912 86515328 NP_001034489.1 2277 1.2e-253 homothorax [Tribolium castaneum]>gi|38490517|emb|CAD57735.1| homothorax [Tribolium castaneum]>gi|270010957|gb|EFA07405.1| hypothetical protein TcasGA2_TC008629 [Tribolium castaneum] 86515327 NM_001039400.1 899 0 Tribolium castaneum homothorax (Hth), mRNA >gnl|BL_ORD_ID|1176366 Tribolium castaneum mRNA for homothorax (hth gene) K16672 HTH homeobox protein homothorax http://www.genome.jp/dbget-bin/www_bget?ko:K16672 O46339 1697 8.5e-188 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.41075 BP_3 207.04 0.95 10826 91090089 XP_975854.1 857 3.0e-88 PREDICTED: protein Tob1 [Tribolium castaneum]>gi|270013495|gb|EFA09943.1| hypothetical protein TcasGA2_TC012096 [Tribolium castaneum] 642934619 XM_970761.2 381 0 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 Q8R5K6 502 1.8e-48 Protein Tob1 OS=Rattus norvegicus GN=Tob1 PE=2 SV=1 PF10766 Multidrug efflux pump-associated protein AcrZ GO:0006855//GO:0015893 drug transmembrane transport//drug transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.41076 BP_3 7546.52 170.99 2419 91088273 XP_967838.1 599 5.5e-59 PREDICTED: protein scylla [Tribolium castaneum]>gi|270012158|gb|EFA08606.1| hypothetical protein TcasGA2_TC006266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTH4 305 2.8e-26 Protein scylla OS=Drosophila melanogaster GN=scyl PE=2 SV=1 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.41079 BP_3 28.29 0.74 2142 642917480 XP_008191219.1 684 6.7e-69 PREDICTED: probable RNA-binding protein 18 [Tribolium castaneum]>gi|270004407|gb|EFA00855.1| hypothetical protein TcasGA2_TC003758 [Tribolium castaneum] 642917479 XM_008192997.1 130 5.22726e-59 PREDICTED: Tribolium castaneum probable RNA-binding protein 18 (LOC103312423), mRNA -- -- -- -- Q6PBM8 234 4.2e-18 Probable RNA-binding protein 18 OS=Danio rerio GN=rbm18 PE=2 SV=1 -- -- -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- -- -- Cluster-8309.41080 BP_3 324.92 3.25 5113 189237669 XP_967427.2 2257 6.4e-251 PREDICTED: hypoxia-inducible factor 1-alpha [Tribolium castaneum] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 Q24167 843 2.4e-88 Protein similar OS=Drosophila melanogaster GN=sima PE=1 SV=2 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3558 Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1 Cluster-8309.41081 BP_3 56.07 0.37 7506 91091506 XP_969096.1 3513 0.0e+00 PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|642936851|ref|XP_008197901.1| PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|270000934|gb|EEZ97381.1| hypothetical protein TcasGA2_TC011206 [Tribolium castaneum] 170030268 XM_001842960.1 189 2.94903e-91 Culex quinquefasciatus ubiquitin-protein ligase E3A, mRNA K10587 UBE3A, E6AP ubiquitin-protein ligase E3 A http://www.genome.jp/dbget-bin/www_bget?ko:K10587 Q05086 2156 2.0e-240 Ubiquitin-protein ligase E3A OS=Homo sapiens GN=UBE3A PE=1 SV=4 PF00632//PF00895//PF15798 HECT-domain (ubiquitin-transferase)//ATP synthase protein 8//Proline-rich AKT1 substrate 1 GO:0016567//GO:0048011//GO:0015992//GO:0015986//GO:0032007 protein ubiquitination//neurotrophin TRK receptor signaling pathway//proton transport//ATP synthesis coupled proton transport//negative regulation of TOR signaling GO:0004842//GO:0015078 ubiquitin-protein transferase activity//hydrogen ion transmembrane transporter activity GO:0005622//GO:0000276 intracellular//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG0941 E3 ubiquitin protein ligase Cluster-8309.41082 BP_3 101.41 0.55 9157 91076832 XP_974636.1 3950 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 224 1.25898e-110 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 Q9Y6R4 854 2.3e-89 Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens GN=MAP3K4 PE=1 SV=2 PF07714//PF00069//PF02744 Protein tyrosine kinase//Protein kinase domain//Galactose-1-phosphate uridyl transferase, C-terminal domain GO:0006012//GO:0006468//GO:0009117 galactose metabolic process//protein phosphorylation//nucleotide metabolic process GO:0000166//GO:0005524//GO:0008108//GO:0004672 nucleotide binding//ATP binding//UDP-glucose:hexose-1-phosphate uridylyltransferase activity//protein kinase activity -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.41083 BP_3 235.59 2.18 5490 546675155 ERL86391.1 1436 1.1e-155 hypothetical protein D910_03799 [Dendroctonus ponderosae] -- -- -- -- -- K14859 SSF1_2 ribosome biogenesis protein SSF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14859 Q9VDE5 989 3.1e-105 Protein Peter pan OS=Drosophila melanogaster GN=ppan PE=1 SV=1 PF05944//PF14863//PF02384//PF13181//PF01555//PF13371//PF00515//PF13414//PF14721//PF02086 Phage small terminase subunit//Alkyl sulfatase dimerisation//N-6 DNA Methylase//Tetratricopeptide repeat//DNA methylase//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term//D12 class N6 adenine-specific DNA methyltransferase GO:0032775//GO:0019069//GO:0006306 DNA methylation on adenine//viral capsid assembly//DNA methylation GO:0046983//GO:0005515//GO:0004519//GO:0003677//GO:0009007//GO:0008170 protein dimerization activity//protein binding//endonuclease activity//DNA binding//site-specific DNA-methyltransferase (adenine-specific) activity//N-methyltransferase activity -- -- KOG2963 RNA-binding protein required for 60S ribosomal subunit biogenesis Cluster-8309.41084 BP_3 945.40 9.74 4972 332375504 AEE62893.1 1136 6.1e-121 unknown [Dendroctonus ponderosae] 573887517 XM_006631469.1 44 7.85208e-11 PREDICTED: Lepisosteus oculatus axonemal dynein light intermediate polypeptide 1-like (LOC102695726), mRNA K10410 DNALI dynein light intermediate chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10410 Q26630 486 5.9e-47 33 kDa inner dynein arm light chain, axonemal OS=Strongylocentrotus purpuratus PE=1 SV=1 PF12474//PF15898//PF02183//PF07850//PF04111//PF01166 Polo kinase kinase//cGMP-dependent protein kinase interacting domain//Homeobox associated leucine zipper//Renin receptor-like protein//Autophagy protein Apg6//TSC-22/dip/bun family GO:0007165//GO:0016310//GO:0009069//GO:0006914//GO:0006355 signal transduction//phosphorylation//serine family amino acid metabolic process//autophagy//regulation of transcription, DNA-templated GO:0004872//GO:0019901//GO:0043565//GO:0004674//GO:0003700 receptor activity//protein kinase binding//sequence-specific DNA binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG4001 Axonemal dynein light chain Cluster-8309.41089 BP_3 349.48 4.13 4370 642910688 XP_008200061.1 1707 3.3e-187 PREDICTED: LOW QUALITY PROTEIN: probable palmitoyltransferase ZDHHC16 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q969W1 740 1.8e-76 Probable palmitoyltransferase ZDHHC16 OS=Homo sapiens GN=ZDHHC16 PE=2 SV=1 PF01529//PF00089 DHHC palmitoyltransferase//Trypsin GO:0006508 proteolysis GO:0008270//GO:0004252 zinc ion binding//serine-type endopeptidase activity -- -- -- -- Cluster-8309.41091 BP_3 137.56 1.50 4725 189242201 XP_972508.2 887 4.3e-92 PREDICTED: protein suppressor of white apricot, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12297 432 1.0e-40 Protein suppressor of white apricot OS=Drosophila melanogaster GN=su(w[a]) PE=1 SV=3 PF04277//PF01805//PF07127 Oxaloacetate decarboxylase, gamma chain//Surp module//Late nodulin protein GO:0006525//GO:0006560//GO:0006814//GO:0071436//GO:0009878//GO:0006090//GO:0006396 arginine metabolic process//proline metabolic process//sodium ion transport//sodium ion export//nodule morphogenesis//pyruvate metabolic process//RNA processing GO:0003723//GO:0008948//GO:0015081//GO:0046872 RNA binding//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity//metal ion binding GO:0016020 membrane KOG1847 mRNA splicing factor Cluster-8309.41093 BP_3 1665.98 85.95 1226 91087587 XP_971919.1 1021 3.2e-108 PREDICTED: ras-related protein Rab-2 [Tribolium castaneum]>gi|270010699|gb|EFA07147.1| hypothetical protein TcasGA2_TC010138 [Tribolium castaneum] 768435213 XM_011560742.1 215 1.65684e-106 PREDICTED: Plutella xylostella ras-related protein Rab-2A (LOC105389599), mRNA K07877 RAB2A Ras-related protein Rab-2A http://www.genome.jp/dbget-bin/www_bget?ko:K07877 Q05975 976 2.2e-104 Ras-related protein Rab-2 OS=Lymnaea stagnalis GN=RAB2 PE=2 SV=1 PF03193//PF08477//PF01926//PF00071//PF04670//PF00025 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ras family//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.41095 BP_3 2250.34 45.61 2670 332375592 AEE62937.1 1523 4.3e-166 unknown [Dendroctonus ponderosae]>gi|478256607|gb|ENN76789.1| hypothetical protein YQE_06630, partial [Dendroctonus ponderosae]>gi|546685197|gb|ERL94724.1| hypothetical protein D910_11998 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08240//PF00107 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.41096 BP_3 528.82 6.57 4169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41098 BP_3 2571.77 26.14 5034 859132801 AKO63316.1 1700 2.4e-186 acetyl CoA acetyltransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 1338 9.5e-146 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF14634//PF00108//PF02803 zinc-RING finger domain//Thiolase, N-terminal domain//Thiolase, C-terminal domain GO:0008152 metabolic process GO:0005515//GO:0016747//GO:0008270 protein binding//transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.41099 BP_3 385.24 2.65 7307 572308871 XP_006620242.1 1074 1.4e-113 PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X1 [Apis dorsata]>gi|572308873|ref|XP_006620243.1| PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X2 [Apis dorsata] 837814424 XM_012928152.1 259 3.50886e-130 PREDICTED: Ochotona princeps ribose-phosphate pyrophosphokinase 1 (LOC101518950), mRNA K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 Q2HJ58 1002 1.3e-106 Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus GN=PRPS1 PE=2 SV=3 PF00156//PF00160//PF14572 Phosphoribosyl transferase domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Phosphoribosyl synthetase-associated domain GO:0000413//GO:0009116//GO:0009165//GO:0006144//GO:0006457//GO:0006098 protein peptidyl-prolyl isomerization//nucleoside metabolic process//nucleotide biosynthetic process//purine nucleobase metabolic process//protein folding//pentose-phosphate shunt GO:0000287//GO:0004749//GO:0003755 magnesium ion binding//ribose phosphate diphosphokinase activity//peptidyl-prolyl cis-trans isomerase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.411 BP_3 4.00 0.40 779 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41101 BP_3 147.35 0.87 8474 642919073 XP_008191722.1 1583 1.5e-172 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 1281 6.5e-139 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.41102 BP_3 80.61 1.14 3697 642935566 XP_008198061.1 3825 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F isoform X1 [Tribolium castaneum] 642935565 XM_008199839.1 1084 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X1, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 2398 8.5e-269 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.41103 BP_3 194.09 2.79 3646 642935570 XP_008198063.1 3792 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F isoform X3 [Tribolium castaneum] 642935569 XM_008199841.1 1108 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X3, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 2413 1.5e-270 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.41106 BP_3 282.45 6.03 2550 91082351 XP_967256.1 613 1.4e-60 PREDICTED: probable uridine nucleosidase 1 [Tribolium castaneum]>gi|270007493|gb|EFA03941.1| hypothetical protein TcasGA2_TC014082 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P6J4 247 1.6e-19 Uncharacterized protein C1683.06c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC1683.06c PE=3 SV=1 PF06156//PF01105//PF05964//PF02212//PF01496 Protein of unknown function (DUF972)//emp24/gp25L/p24 family/GOLD//F/Y-rich N-terminus//Dynamin GTPase effector domain//V-type ATPase 116kDa subunit family GO:0015992//GO:0006260//GO:0006810//GO:0015991 proton transport//DNA replication//transport//ATP hydrolysis coupled proton transport GO:0005525//GO:0015078//GO:0003924 GTP binding//hydrogen ion transmembrane transporter activity//GTPase activity GO:0033179//GO:0016021//GO:0005634 proton-transporting V-type ATPase, V0 domain//integral component of membrane//nucleus KOG2938 Predicted inosine-uridine preferring nucleoside hydrolase Cluster-8309.41112 BP_3 565.00 9.35 3203 642913576 XP_008201070.1 1499 3.2e-163 PREDICTED: delta(14)-sterol reductase-like [Tribolium castaneum]>gi|270001705|gb|EEZ98152.1| hypothetical protein TcasGA2_TC000578 [Tribolium castaneum] -- -- -- -- -- K19532 LBR lamin-B receptor http://www.genome.jp/dbget-bin/www_bget?ko:K19532 O08984 572 4.0e-57 Lamin-B receptor OS=Rattus norvegicus GN=Lbr PE=1 SV=1 PF04140//PF01222 Isoprenylcysteine carboxyl methyltransferase (ICMT) family//Ergosterol biosynthesis ERG4/ERG24 family GO:0006479//GO:0006481 protein methylation//C-terminal protein methylation GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1435 Sterol reductase/lamin B receptor Cluster-8309.41113 BP_3 775.08 6.18 6339 189236266 XP_974475.2 971 1.0e-101 PREDICTED: transmembrane protein 53 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ULP2 147 1.5e-07 Aftiphilin OS=Homo sapiens GN=AFTPH PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41114 BP_3 1023.00 7.60 6783 642911668 XP_008200693.1 4171 0.0e+00 PREDICTED: chondroitin sulfate proteoglycan 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UVK1 1054 1.1e-112 Chondroitin sulfate proteoglycan 4 OS=Homo sapiens GN=CSPG4 PE=1 SV=2 PF00008//PF01024//PF15880 EGF-like domain//Colicin pore forming domain//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0005515 protein binding GO:0016021//GO:0005747//GO:0005739 integral component of membrane//mitochondrial respiratory chain complex I//mitochondrion KOG3597 Proteoglycan Cluster-8309.41116 BP_3 790.19 3.48 11251 642925080 XP_008194161.1 4665 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A1 [Tribolium castaneum] 573902448 XM_006638886.1 156 9.78986e-73 PREDICTED: Lepisosteus oculatus lysine-specific demethylase 6A-like (LOC102692642), transcript variant X4, mRNA K14950 ATP13A1 cation-transporting ATPase 13A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14950 Q9HD20 3312 0.0e+00 Manganese-transporting ATPase 13A1 OS=Homo sapiens GN=ATP13A1 PE=1 SV=2 PF02388//PF13414//PF00515//PF00782//PF03938//PF00122//PF13949//PF00102//PF13181//PF08797 FemAB family//TPR repeat//Tetratricopeptide repeat//Dual specificity phosphatase, catalytic domain//Outer membrane protein (OmpH-like)//E1-E2 ATPase//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//Tetratricopeptide repeat//HIRAN domain GO:0006570//GO:0006470//GO:0009252 tyrosine metabolic process//protein dephosphorylation//peptidoglycan biosynthetic process GO:0004725//GO:0008138//GO:0005515//GO:0016755//GO:0046872//GO:0016818//GO:0003676//GO:0051082//GO:0008270//GO:0000166 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//transferase activity, transferring amino-acyl groups//metal ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//unfolded protein binding//zinc ion binding//nucleotide binding -- -- KOG0209 P-type ATPase Cluster-8309.41117 BP_3 186.10 1.46 6437 270015299 EFA11747.1 475 3.5e-44 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041//PF02184 Fibronectin type III domain//HAT (Half-A-TPR) repeat GO:0006396 RNA processing GO:0005515 protein binding GO:0005622 intracellular -- -- Cluster-8309.41119 BP_3 547.72 24.76 1358 332374922 AEE62602.1 939 1.2e-98 unknown [Dendroctonus ponderosae]>gi|478263079|gb|ENN81479.1| hypothetical protein YQE_02171, partial [Dendroctonus ponderosae]>gi|546682121|gb|ERL92102.1| hypothetical protein D910_09423 [Dendroctonus ponderosae] -- -- -- -- -- K09562 HSPBP1 hsp70-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K09562 Q99P31 320 2.8e-28 Hsp70-binding protein 1 OS=Mus musculus GN=Hspbp1 PE=2 SV=1 PF01602//PF00514//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//HEAT repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG2160 Armadillo/beta-catenin-like repeat-containing protein Cluster-8309.41121 BP_3 26.52 0.66 2223 478252633 ENN73038.1 1163 2.0e-124 hypothetical protein YQE_10373, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TMP0 386 1.0e-35 Uncharacterized serpin-like protein MA_2613/MA_2612 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=MA_2613/MA_2612 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41125 BP_3 3265.38 22.19 7385 642918353 XP_008199964.1 4772 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 F1PBJ0 2374 1.0e-265 Rap guanine nucleotide exchange factor 2 OS=Canis familiaris GN=RAPGEF2 PE=1 SV=2 PF13180//PF00617//PF00595//PF00788 PDZ domain//RasGEF domain//PDZ domain (Also known as DHR or GLGF)//Ras association (RalGDS/AF-6) domain GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.41127 BP_3 1878.47 44.66 2319 270003863 EFA00311.1 1778 1.0e-195 hypothetical protein TcasGA2_TC003147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41129 BP_3 591.04 5.02 5972 642924318 XP_008194246.1 2380 4.1e-265 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 1111 2.4e-119 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 PF05971//PF02714//PF12822//PF01504 Protein of unknown function (DUF890)//Calcium-dependent channel, 7TM region, putative phosphate//Protein of unknown function (DUF3816)//Phosphatidylinositol-4-phosphate 5-Kinase GO:0006821//GO:0006810//GO:0046488//GO:0006820 chloride transport//transport//phosphatidylinositol metabolic process//anion transport GO:0005215//GO:0005254//GO:0008168//GO:0016307 transporter activity//chloride channel activity//methyltransferase activity//phosphatidylinositol phosphate kinase activity GO:0016020//GO:0034707 membrane//chloride channel complex KOG2514 Uncharacterized conserved protein Cluster-8309.41133 BP_3 248.39 3.00 4277 91084191 XP_967340.1 2823 0.0e+00 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270008779|gb|EFA05227.1| hypothetical protein TcasGA2_TC015371 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 2100 3.5e-234 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF05834//PF07992//PF00732//PF10399 GMC oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal GO:0006119//GO:0006066//GO:0006563//GO:0055114//GO:0006544//GO:0015992//GO:0006118//GO:0016117//GO:0006566 oxidative phosphorylation//alcohol metabolic process//L-serine metabolic process//oxidation-reduction process//glycine metabolic process//proton transport//obsolete electron transport//carotenoid biosynthetic process//threonine metabolic process GO:0008121//GO:0016491//GO:0016614//GO:0016705//GO:0008812//GO:0050660 ubiquinol-cytochrome-c reductase activity//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.41134 BP_3 979.53 6.21 7898 91093216 XP_966931.1 11506 0.0e+00 PREDICTED: pre-mRNA-processing-splicing factor 8 [Tribolium castaneum]>gi|270016589|gb|EFA13035.1| hypothetical protein TcasGA2_TC010565 [Tribolium castaneum] 642938178 XM_961838.2 2460 0 PREDICTED: Tribolium castaneum pre-mRNA-processing-splicing factor 8 (LOC655310), mRNA K12856 PRPF8, PRP8 pre-mRNA-processing factor 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12856 Q6P2Q9 10945 0.0e+00 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens GN=PRPF8 PE=1 SV=2 PF08083//PF10147//PF10596//PF10597//PF03153//PF10598//PF08082//PF01398 PROCN (NUC071) domain//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//U6-snRNA interacting domain of PrP8//U5-snRNA binding site 2 of PrP8//Transcription factor IIA, alpha/beta subunit//RNA recognition motif of the spliceosomal PrP8//PRO8NT (NUC069), PrP8 N-terminal domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0000398//GO:0006367//GO:0007049 mRNA splicing, via spliceosome//transcription initiation from RNA polymerase II promoter//cell cycle GO:0003723//GO:0005515//GO:0017070//GO:0030623 RNA binding//protein binding//U6 snRNA binding//U5 snRNA binding GO:0005634//GO:0005681//GO:0005672 nucleus//spliceosomal complex//transcription factor TFIIA complex KOG1795 U5 snRNP spliceosome subunit Cluster-8309.41138 BP_3 271.57 5.34 2744 642931607 XP_008196654.1 4104 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 756 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 2955 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02171//PF02170//PF04810 Piwi domain//PAZ domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003676//GO:0008270 protein binding//nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.41139 BP_3 748.48 6.84 5565 642931607 XP_008196654.1 4512 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 826 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3322 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02171//PF02170//PF04810 Piwi domain//PAZ domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003676//GO:0008270 protein binding//nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.4114 BP_3 12.00 0.98 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41140 BP_3 5434.14 86.41 3323 642911714 XP_008200711.1 876 5.7e-91 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 704 2.1e-72 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.41141 BP_3 265.22 3.33 4135 642931115 XP_008201667.1 431 2.8e-39 PREDICTED: autism susceptibility gene 2 protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04617//PF08597 Hox9 activation region//Translation initiation factor eIF3 subunit GO:0006446//GO:0006351 regulation of translational initiation//transcription, DNA-templated GO:0003743 translation initiation factor activity GO:0005737//GO:0005852//GO:0005840//GO:0005634 cytoplasm//eukaryotic translation initiation factor 3 complex//ribosome//nucleus -- -- Cluster-8309.41143 BP_3 57.83 0.76 3960 642935257 XP_008197935.1 1817 5.2e-200 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q6NRG5 1164 1.1e-125 NADPH-dependent diflavin oxidoreductase 1 OS=Xenopus laevis GN=ndor1 PE=2 SV=1 PF00175//PF12641//PF01344//PF00667//PF00258 Oxidoreductase NAD-binding domain//Flavodoxin domain//Kelch motif//FAD binding domain//Flavodoxin GO:0055114 oxidation-reduction process GO:0010181//GO:0005515//GO:0016491 FMN binding//protein binding//oxidoreductase activity -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.41144 BP_3 487.26 6.55 3880 642920179 XP_008192235.1 372 1.8e-32 PREDICTED: uncharacterized protein LOC103312687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04976 DMSO reductase anchor subunit (DmsC) GO:0019645 anaerobic electron transport chain -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41145 BP_3 997.29 17.15 3095 332376929 AEE63604.1 1043 2.3e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q05319 445 2.1e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41146 BP_3 1361.80 3.39 19648 646716100 KDR19487.1 3053 0.0e+00 E3 ubiquitin-protein ligase MARCH6 [Zootermopsis nevadensis] 847042359 XM_012951711.1 93 1.79831e-37 PREDICTED: Jaculus jaculus membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (March6), mRNA K10661 MARCH6, DOA10 E3 ubiquitin-protein ligase MARCH6 http://www.genome.jp/dbget-bin/www_bget?ko:K10661 O60337 1868 1.3e-206 E3 ubiquitin-protein ligase MARCH6 OS=Homo sapiens GN=MARCH6 PE=1 SV=2 PF12906//PF03165//PF00400//PF13639//PF00004 RING-variant domain//MH1 domain//WD domain, G-beta repeat//Ring finger domain//ATPase family associated with various cellular activities (AAA) GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0005524//GO:0008270 protein binding//ATP binding//zinc ion binding GO:0005622 intracellular KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.41147 BP_3 433.53 5.71 3953 642931208 XP_008196484.1 1228 1.0e-131 PREDICTED: WD repeat domain phosphoinositide-interacting protein 2 isoform X3 [Tribolium castaneum]>gi|270012114|gb|EFA08562.1| hypothetical protein TcasGA2_TC006217 [Tribolium castaneum] -- -- -- -- -- K17908 WIPI, ATG18 autophagy-related protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K17908 Q9Y4P8 862 1.2e-90 WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens GN=WIPI2 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2110 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.41148 BP_3 5319.14 69.03 4006 91094331 XP_966352.1 4668 0.0e+00 PREDICTED: ubiquitin-like modifier-activating enzyme 1 [Tribolium castaneum] 766942063 XM_011505379.1 303 6.65416e-155 PREDICTED: Ceratosolen solmsi marchali ubiquitin-like modifier-activating enzyme 1 (LOC105366815), mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 Q29504 3516 0.0e+00 Ubiquitin-like modifier-activating enzyme 1 OS=Oryctolagus cuniculus GN=UBA1 PE=2 SV=1 PF13241//PF00899//PF00070//PF01006 Putative NAD(P)-binding//ThiF family//Pyridine nucleotide-disulphide oxidoreductase//Hepatitis C virus non-structural protein NS4a GO:0016032//GO:0019354//GO:0006779//GO:0055114 viral process//siroheme biosynthetic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0043115//GO:0016491//GO:0008641 precorrin-2 dehydrogenase activity//oxidoreductase activity//small protein activating enzyme activity GO:0019012 virion KOG2012 Ubiquitin activating enzyme UBA1 Cluster-8309.41150 BP_3 12.81 0.36 2023 91091818 XP_966528.1 1068 1.9e-113 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 714 8.7e-74 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0005216//GO:0005234//GO:0004970 ion channel activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.41151 BP_3 135.38 1.25 5498 642930363 XP_008196367.1 923 3.4e-96 PREDICTED: protein DEK isoform X3 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.87451e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.41152 BP_3 732.63 26.17 1641 91088249 XP_966392.1 2026 1.3e-224 PREDICTED: myosin-IA [Tribolium castaneum]>gi|270011817|gb|EFA08265.1| hypothetical protein TcasGA2_TC005895 [Tribolium castaneum] 755988894 XM_011313704.1 50 1.18062e-14 PREDICTED: Fopius arisanus myosin-IA (LOC105271894), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 1435 1.8e-157 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF06017//PF00612//PF00063 Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Myosin head (motor domain) -- -- GO:0003774//GO:0005524//GO:0005515 motor activity//ATP binding//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.41155 BP_3 725.43 8.29 4507 546679118 ERL89623.1 1551 4.2e-169 hypothetical protein D910_06988 [Dendroctonus ponderosae] 195146567 XM_002014220.1 155 1.40428e-72 Drosophila persimilis gpdh (Dper\Gpdh), mRNA K00006 GPD1 glycerol-3-phosphate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00006 O97463 1392 4.7e-152 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Drosophila kanekoi GN=Gpdh1 PE=3 SV=3 PF01210//PF03523//PF12153//PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Macrophage scavenger receptor//LPS binding domain of CAP18 (C terminal)//NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus GO:0046168//GO:0042742//GO:0006898//GO:0006072//GO:0007165//GO:0046486//GO:0005975//GO:0055114 glycerol-3-phosphate catabolic process//defense response to bacterium//receptor-mediated endocytosis//glycerol-3-phosphate metabolic process//signal transduction//glycerolipid metabolic process//carbohydrate metabolic process//oxidation-reduction process GO:0005044//GO:0016616//GO:0051287//GO:0004367 scavenger receptor activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//glycerol-3-phosphate dehydrogenase [NAD+] activity GO:0016020//GO:0009331 membrane//glycerol-3-phosphate dehydrogenase complex KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase Cluster-8309.41156 BP_3 747.89 4.42 8443 546680590 ERL90833.1 6072 0.0e+00 hypothetical protein D910_08178 [Dendroctonus ponderosae] 642925848 XM_008192328.1 61 4.74039e-20 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- Q6DFF9 2154 3.8e-240 Mitogen-activated protein kinase-binding protein 1 OS=Xenopus laevis GN=mapkbp1 PE=2 SV=1 PF08367//PF00400 Peptidase M16C associated//WD domain, G-beta repeat GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG1408 WD40 repeat protein Cluster-8309.41158 BP_3 296.91 10.37 1672 546684210 ERL93915.1 1470 3.8e-160 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 94 4.1778e-39 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1096 3.6e-118 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.41160 BP_3 274.67 5.82 2566 546685769 ERL95218.1 2378 3.0e-265 hypothetical protein D910_12485 [Dendroctonus ponderosae] 514694901 XM_004994965.1 65 8.53497e-23 Salpingoeca rosetta bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase mRNA K13811 PAPSS 3'-phosphoadenosine 5'-phosphosulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13811 O95340 2061 7.1e-230 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Homo sapiens GN=PAPSS2 PE=1 SV=2 PF01293//PF01747//PF01583 Phosphoenolpyruvate carboxykinase//ATP-sulfurylase//Adenylylsulphate kinase GO:0006094//GO:0006099//GO:0015976//GO:0006790//GO:0006144//GO:0000103 gluconeogenesis//tricarboxylic acid cycle//carbon utilization//sulfur compound metabolic process//purine nucleobase metabolic process//sulfate assimilation GO:0004612//GO:0005524//GO:0004781//GO:0004020 phosphoenolpyruvate carboxykinase (ATP) activity//ATP binding//sulfate adenylyltransferase (ATP) activity//adenylylsulfate kinase activity -- -- KOG4238 Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase Cluster-8309.41161 BP_3 517.07 1.90 13413 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 81 5.74927e-31 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q924T7 884 1.1e-92 E3 ubiquitin-protein ligase RNF31 OS=Mus musculus GN=Rnf31 PE=1 SV=2 PF07975//PF05121//PF01426//PF13465//PF08273//PF02845//PF00412//PF00641//PF09182//PF13912//PF05495//PF00096//PF07776 TFIIH C1-like domain//Gas vesicle protein K//BAH domain//Zinc-finger double domain//Zinc-binding domain of primase-helicase//CUE domain//LIM domain//Zn-finger in Ran binding protein and others//Bacterial purine repressor, N-terminal//C2H2-type zinc finger//CHY zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0006281//GO:0031412//GO:0006269//GO:0006355//GO:0006351 DNA repair//gas vesicle organization//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//transcription, DNA-templated GO:0003896//GO:0008270//GO:0003682//GO:0003677//GO:0004386//GO:0005515//GO:0046872 DNA primase activity//zinc ion binding//chromatin binding//DNA binding//helicase activity//protein binding//metal ion binding GO:0005730//GO:0005634//GO:0005657//GO:0000785 nucleolus//nucleus//replication fork//chromatin -- -- Cluster-8309.41162 BP_3 1.00 0.90 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41163 BP_3 19.00 6.50 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41166 BP_3 288.66 2.62 5598 91088115 XP_969791.1 1930 5.8e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.6e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF01105//PF02966//PF04851 DEAD/DEAH box helicase//emp24/gp25L/p24 family/GOLD//Mitosis protein DIM1//Type III restriction enzyme, res subunit GO:0000398//GO:0006810 mRNA splicing, via spliceosome//transport GO:0003676//GO:0016787//GO:0003677//GO:0005524//GO:0008026 nucleic acid binding//hydrolase activity//DNA binding//ATP binding//ATP-dependent helicase activity GO:0016021//GO:0005681 integral component of membrane//spliceosomal complex KOG0330 ATP-dependent RNA helicase Cluster-8309.41167 BP_3 627.74 4.89 6477 675379920 KFM72822.1 1258 5.6e-135 Transposable element P transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF07967//PF08558 THAP domain//C3HC zinc finger-like//Telomere repeat binding factor (TRF) -- -- GO:0003676//GO:0008270//GO:0042803//GO:0042162 nucleic acid binding//zinc ion binding//protein homodimerization activity//telomeric DNA binding GO:0005634 nucleus -- -- Cluster-8309.4117 BP_3 2.00 0.31 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41170 BP_3 108.59 9.62 836 478252357 ENN72783.1 568 7.4e-56 hypothetical protein YQE_10588, partial [Dendroctonus ponderosae]>gi|546680689|gb|ERL90915.1| hypothetical protein D910_08259 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A4QNC6 277 1.7e-23 Protein FAM136A OS=Xenopus tropicalis GN=fam136a PE=2 SV=1 PF02970//PF07464 Tubulin binding cofactor A//Apolipophorin-III precursor (apoLp-III) GO:0007021//GO:0006869 tubulin complex assembly//lipid transport GO:0051082//GO:0008289//GO:0015631 unfolded protein binding//lipid binding//tubulin binding GO:0005576//GO:0045298 extracellular region//tubulin complex KOG3377 Uncharacterized conserved protein Cluster-8309.41171 BP_3 244.61 6.54 2094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41173 BP_3 20.48 1.61 903 642936923 XP_970894.2 287 3.1e-23 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.41174 BP_3 782.29 4.52 8641 642937304 XP_008198778.1 1898 4.6e-209 PREDICTED: zinc finger SWIM domain-containing protein 8 [Tribolium castaneum] 194892748 XM_001977686.1 154 9.71651e-72 Drosophila erecta GG19197 (Dere\GG19197), mRNA -- -- -- -- A7E2V4 868 5.2e-91 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 PF02024 Leptin GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region KOG3615 Uncharacterized conserved protein Cluster-8309.41175 BP_3 5877.96 27.33 10659 91080713 XP_975329.1 4737 0.0e+00 PREDICTED: leucine-rich PPR motif-containing protein, mitochondrial [Tribolium castaneum]>gi|270005471|gb|EFA01919.1| hypothetical protein TcasGA2_TC007529 [Tribolium castaneum] -- -- -- -- -- K17964 LRPPRC leucine-rich PPR motif-containing protein, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17964 P42704 1298 8.8e-141 Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens GN=LRPPRC PE=1 SV=3 PF00014//PF00536//PF07647//PF09246//PF13181//PF13414//PF00637//PF00515 Kunitz/Bovine pancreatic trypsin inhibitor domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PHAT//Tetratricopeptide repeat//TPR repeat//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0006355//GO:0016192//GO:0006886 regulation of transcription, DNA-templated//vesicle-mediated transport//intracellular protein transport GO:0003723//GO:0004867//GO:0005515 RNA binding//serine-type endopeptidase inhibitor activity//protein binding -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.41176 BP_3 393.19 7.72 2748 642918856 XP_008191616.1 1413 2.5e-153 PREDICTED: pericentriolar material 1 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76329 140 4.3e-07 Interaptin OS=Dictyostelium discoideum GN=abpD PE=1 SV=1 PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.41178 BP_3 363.82 2.03 8940 642936570 XP_008198490.1 5154 0.0e+00 PREDICTED: guanylate cyclase 32E isoform X2 [Tribolium castaneum] 642936569 XM_008200268.1 589 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X2, mRNA -- -- -- -- Q07553 1915 2.1e-212 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00558//PF07701//PF01073//PF15427//PF00056//PF00069//PF02866//PF00211//PF07714 Vpu protein//Heme NO binding associated//3-beta hydroxysteroid dehydrogenase/isomerase family//S100P-binding protein//lactate/malate dehydrogenase, NAD binding domain//Protein kinase domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase GO:0032801//GO:0006182//GO:0008210//GO:0006144//GO:0019076//GO:0006812//GO:0008207//GO:0035556//GO:0055114//GO:0006694//GO:0008209//GO:0009190//GO:0046039//GO:0006468 receptor catabolic process//cGMP biosynthetic process//estrogen metabolic process//purine nucleobase metabolic process//viral release from host cell//cation transport//C21-steroid hormone metabolic process//intracellular signal transduction//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//cyclic nucleotide biosynthetic process//GTP metabolic process//protein phosphorylation GO:0004672//GO:0016849//GO:0016491//GO:0004383//GO:0048306//GO:0003854//GO:0005524//GO:0005261//GO:0016616 protein kinase activity//phosphorus-oxygen lyase activity//oxidoreductase activity//guanylate cyclase activity//calcium-dependent protein binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//ATP binding//cation channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.41180 BP_3 43.98 1.24 1999 642923490 XP_008193532.1 1769 9.7e-195 PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum]>gi|642923492|ref|XP_967512.2| PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum] 198474593 XM_002132688.1 75 1.82845e-28 Drosophila pseudoobscura pseudoobscura GA25723 (Dpse\GA25723), partial mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 1234 4.3e-134 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00159//PF00852 Pancreatic hormone peptide//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486//GO:0007165 protein glycosylation//signal transduction GO:0005179//GO:0008417 hormone activity//fucosyltransferase activity GO:0005576//GO:0016020 extracellular region//membrane KOG2619 Fucosyltransferase Cluster-8309.41182 BP_3 17.98 0.71 1508 270001943 EEZ98390.1 619 1.6e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 5.61734e-117 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 7.0e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.41183 BP_3 400.42 5.60 3739 478263448 ENN81809.1 1986 1.2e-219 hypothetical protein YQE_01814, partial [Dendroctonus ponderosae]>gi|478263929|gb|ENN82095.1| hypothetical protein YQE_01527, partial [Dendroctonus ponderosae] 817188109 XM_012433187.1 139 9.11915e-64 PREDICTED: Orussus abietinus tubulin alpha chain-like (LOC105704177), mRNA -- -- -- -- Q7Z3E2 973 1.5e-103 Coiled-coil domain-containing protein 186 OS=Homo sapiens GN=CCDC186 PE=1 SV=2 PF13014 KH domain -- -- GO:0003723 RNA binding -- -- KOG1376 Alpha tubulin Cluster-8309.41185 BP_3 526.03 10.10 2801 270004464 EFA00912.1 1317 3.5e-142 hypothetical protein TcasGA2_TC003818 [Tribolium castaneum] 642917680 XM_008193104.1 197 3.90008e-96 PREDICTED: Tribolium castaneum poly(A) polymerase type 3 (LOC103312455), transcript variant X2, mRNA K14376 PAP poly(A) polymerase http://www.genome.jp/dbget-bin/www_bget?ko:K14376 Q6PCL9 1005 2.2e-107 Poly(A) polymerase gamma OS=Mus musculus GN=Papolg PE=1 SV=1 PF04928//PF04926 Poly(A) polymerase central domain//Poly(A) polymerase predicted RNA binding domain GO:0043631 RNA polyadenylation GO:0004652//GO:0003723 polynucleotide adenylyltransferase activity//RNA binding -- -- KOG2245 Poly(A) polymerase and related nucleotidyltransferases Cluster-8309.41186 BP_3 29.64 0.80 2082 642919403 XP_008191855.1 1871 1.5e-206 PREDICTED: ubiquitin carboxyl-terminal hydrolase 46 [Tribolium castaneum] 642919402 XM_008193633.1 582 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 46 (LOC663037), mRNA K11842 USP12_46 ubiquitin carboxyl-terminal hydrolase 12/46 http://www.genome.jp/dbget-bin/www_bget?ko:K11842 P62068 1430 8.5e-157 Ubiquitin carboxyl-terminal hydrolase 46 OS=Homo sapiens GN=USP46 PE=1 SV=1 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0036459//GO:0032183//GO:0070140 ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.41187 BP_3 199.33 3.53 3016 189234074 XP_970690.2 1301 2.7e-140 PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum]>gi|642912025|ref|XP_008199064.1| PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01785 galM, GALM aldose 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01785 Q66HG4 743 5.6e-77 Aldose 1-epimerase OS=Rattus norvegicus GN=Galm PE=1 SV=1 PF05365//PF01263 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Aldose 1-epimerase GO:0005975//GO:0006122 carbohydrate metabolic process//mitochondrial electron transport, ubiquinol to cytochrome c GO:0016853 isomerase activity GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane KOG1604 Predicted mutarotase Cluster-8309.41188 BP_3 295.83 2.40 6244 478250592 ENN71084.1 843 7.2e-87 hypothetical protein YQE_12017, partial [Dendroctonus ponderosae]>gi|546672947|gb|ERL84655.1| hypothetical protein D910_02082 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GLM5 402 4.1e-37 Desumoylating isopeptidase 1 OS=Xenopus laevis GN=desi1 PE=2 SV=1 PF06453 Type II heat-labile enterotoxin , B subunit (LT-IIB) GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG0324 Uncharacterized conserved protein Cluster-8309.4119 BP_3 1.00 0.69 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41190 BP_3 91.41 3.94 1409 91079626 XP_967654.1 1329 7.2e-144 PREDICTED: 28S ribosomal protein S29, mitochondrial [Tribolium castaneum]>gi|270004472|gb|EFA00920.1| hypothetical protein TcasGA2_TC003826 [Tribolium castaneum] -- -- -- -- -- K17408 DAP3, MRPS29 small subunit ribosomal protein S29 http://www.genome.jp/dbget-bin/www_bget?ko:K17408 P82922 749 5.3e-78 28S ribosomal protein S29, mitochondrial OS=Bos taurus GN=DAP3 PE=1 SV=3 PF04659 Archaeal flagella protein GO:0097588//GO:0006915 archaeal or bacterial-type flagellum-dependent cell motility//apoptotic process -- -- GO:0005761//GO:0015935 mitochondrial ribosome//small ribosomal subunit KOG3928 Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3 Cluster-8309.41191 BP_3 1.00 12.22 238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41192 BP_3 89.09 1.12 4117 642939400 XP_008193248.1 467 1.9e-43 PREDICTED: uncharacterized protein LOC103312106 [Tribolium castaneum]>gi|270016475|gb|EFA12921.1| hypothetical protein TcasGA2_TC006991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41193 BP_3 70.75 0.86 4270 91078850 XP_971848.1 1166 1.7e-124 PREDICTED: uncharacterized protein LOC660531 [Tribolium castaneum]>gi|270004130|gb|EFA00578.1| hypothetical protein TcasGA2_TC003448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03604 DNA directed RNA polymerase, 7 kDa subunit GO:0006206//GO:0006351//GO:0042318//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//penicillin biosynthetic process//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.41194 BP_3 131.07 1.82 3759 91076338 XP_971007.1 1162 4.4e-124 PREDICTED: protein TAPT1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VED0 770 5.2e-80 Protein TAPT1 homolog OS=Drosophila melanogaster GN=CG7218 PE=2 SV=2 PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG2490 Predicted membrane protein Cluster-8309.41196 BP_3 2.00 0.49 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41197 BP_3 1642.89 12.37 6692 157111277 XP_001651466.1 5483 0.0e+00 AAEL005801-PA [Aedes aegypti]>gi|108878460|gb|EAT42685.1| AAEL005801-PA [Aedes aegypti] 170063636 XM_001867153.1 197 9.38404e-96 Culex quinquefasciatus bifunctional aminoacyl-tRNA synthetase, mRNA K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 P28668 5286 0.0e+00 Bifunctional glutamate/proline--tRNA ligase OS=Drosophila melanogaster GN=Aats-glupro PE=1 SV=2 PF03950//PF00587//PF00749//PF00992//PF00458//PF09180//PF02146 tRNA synthetases class I (E and Q), anti-codon binding domain//tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class I (E and Q), catalytic domain//Troponin//WHEP-TRS domain//Prolyl-tRNA synthetase, C-terminal//Sir2 family GO:0006433//GO:0006418//GO:0043039//GO:0006525//GO:0006560 prolyl-tRNA aminoacylation//tRNA aminoacylation for protein translation//tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0004827//GO:0000166//GO:0004812//GO:0016876//GO:0005524//GO:0070403 proline-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity//ligase activity, forming aminoacyl-tRNA and related compounds//ATP binding//NAD+ binding GO:0005861//GO:0005737 troponin complex//cytoplasm KOG4163 Prolyl-tRNA synthetase Cluster-8309.41198 BP_3 36.28 1.02 2001 332374418 AEE62350.1 1308 2.8e-141 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01939 646 6.6e-66 Protein misato OS=Drosophila melanogaster GN=mst PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG2530 Members of tubulin/FtsZ family Cluster-8309.41201 BP_3 50.27 2.33 1331 270016044 EFA12492.1 500 9.1e-48 hypothetical protein TcasGA2_TC012892 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938 Outer membrane protein (OmpH-like) -- -- GO:0051082 unfolded protein binding -- -- -- -- Cluster-8309.41203 BP_3 5.00 0.34 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41204 BP_3 399.82 3.49 5811 91078406 XP_974522.1 1843 7.4e-203 PREDICTED: cirhin [Tribolium castaneum]>gi|270003991|gb|EFA00439.1| hypothetical protein TcasGA2_TC003293 [Tribolium castaneum] -- -- -- -- -- K14548 UTP4, CIRH1A U3 small nucleolar RNA-associated protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14548 Q969X6 720 5.0e-74 Cirhin OS=Homo sapiens GN=CIRH1A PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2048 WD40 repeat protein Cluster-8309.41205 BP_3 373.00 3.44 5524 478256258 ENN76448.1 3712 0.0e+00 hypothetical protein YQE_06902, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O60287 465 1.8e-44 Nucleolar pre-ribosomal-associated protein 1 OS=Homo sapiens GN=URB1 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG1791 Uncharacterized conserved protein Cluster-8309.41206 BP_3 10.00 0.70 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41207 BP_3 856.83 3.47 12193 642913916 XP_008201212.1 3044 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X1 [Tribolium castaneum] 755870656 XM_005181954.2 137 3.87123e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 P51812 2107 1.6e-234 Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1 PF06293//PF00069//PF07714//PF00433 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0016773//GO:0004674//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.4121 BP_3 81.32 1.34 3212 642937090 XP_008198688.1 885 5.0e-92 PREDICTED: nose resistant to fluoxetine protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 330 4.7e-29 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.41211 BP_3 48.00 1.29 2088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41213 BP_3 377.68 1.92 9781 642910643 XP_008200041.1 6865 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: plexin-B [Tribolium castaneum] 571537979 XM_395735.5 266 6.04074e-134 PREDICTED: Apis mellifera plexin B (plexB), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 Q9V4A7 4832 0.0e+00 Plexin-B OS=Drosophila melanogaster GN=plexB PE=1 SV=2 PF01833//PF04414//PF01756//PF01437//PF00441//PF01403//PF02770 IPT/TIG domain//D-aminoacyl-tRNA deacylase//Acyl-CoA oxidase//Plexin repeat//Acyl-CoA dehydrogenase, C-terminal domain//Sema domain//Acyl-CoA dehydrogenase, middle domain GO:0055114//GO:0006118//GO:0006635//GO:0006637 oxidation-reduction process//obsolete electron transport//fatty acid beta-oxidation//acyl-CoA metabolic process GO:0016627//GO:0003997//GO:0051499//GO:0005515//GO:0003995//GO:0016788 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity//D-aminoacyl-tRNA deacylase activity//protein binding//acyl-CoA dehydrogenase activity//hydrolase activity, acting on ester bonds GO:0016020//GO:0005777 membrane//peroxisome KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.41214 BP_3 105.64 1.34 4105 642917674 XP_008193576.1 1226 1.8e-131 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 4-like [Tribolium castaneum] -- -- -- -- -- K15426 PPP4R4 serine/threonine-protein phosphatase 4 regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15426 Q8C0Y0 745 4.5e-77 Serine/threonine-protein phosphatase 4 regulatory subunit 4 OS=Mus musculus GN=Ppp4r4 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3040 Predicted sugar phosphatase (HAD superfamily) Cluster-8309.41215 BP_3 293.20 4.21 3649 478256507 ENN76691.1 1019 1.6e-107 hypothetical protein YQE_06756, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AYR6 722 1.9e-74 Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Rattus norvegicus GN=Hdhd2 PE=2 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG3040 Predicted sugar phosphatase (HAD superfamily) Cluster-8309.41216 BP_3 184.61 6.64 1631 189235090 XP_968736.2 1849 4.2e-204 PREDICTED: transmembrane protein 184B isoform X1 [Tribolium castaneum]>gi|270004019|gb|EFA00467.1| hypothetical protein TcasGA2_TC003325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2VDL9 1088 3.0e-117 Transmembrane protein 184B OS=Bos taurus GN=TMEM184B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.41217 BP_3 25.73 0.42 3212 546684288 ERL93993.1 1409 8.6e-153 hypothetical protein D910_11278 [Dendroctonus ponderosae] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 719 3.6e-74 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF10394//PF01061 Histone acetyl transferase HAT1 N-terminus//ABC-2 type transporter GO:0016568//GO:0042967 chromatin modification//acyl-carrier-protein biosynthetic process GO:0004402 histone acetyltransferase activity GO:0016020//GO:0000123 membrane//histone acetyltransferase complex -- -- Cluster-8309.41218 BP_3 74.36 0.38 9612 642918629 XP_008200387.1 1253 3.2e-134 PREDICTED: serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2 [Tribolium castaneum] 642918632 XM_008202178.1 261 3.57254e-131 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 6 regulatory subunit 3 (LOC655675), transcript variant X5, mRNA K15501 PPP6R3, SAPS3 serine/threonine-protein phosphatase 6 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15501 O75170 775 3.5e-80 Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens GN=PPP6R2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2073 SAP family cell cycle dependent phosphatase-associated protein Cluster-8309.4122 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41221 BP_3 1134.81 7.71 7388 91079112 XP_975371.1 1029 2.3e-108 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 3.5e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF03370//PF03423//PF16760 Carbohydrate/starch-binding module (family 21)//Carbohydrate binding domain (family 25)//Starch/carbohydrate-binding module (family 53) -- -- GO:0005515//GO:2001070 protein binding//starch binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.41222 BP_3 30.38 2.23 949 546685593 ERL95080.1 1153 1.2e-123 hypothetical protein D910_12350 [Dendroctonus ponderosae] 116194437 XM_001223030.1 57 8.64257e-19 Chaetomium globosum CBS 148.51 hypothetical protein (CHGG_03817) partial mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q9D4H8 572 1.2e-57 Cullin-2 OS=Mus musculus GN=Cul2 PE=1 SV=2 PF06180//PF00888//PF08469 Cobalt chelatase (CbiK)//Cullin family//Nucleoside triphosphatase I C-terminal GO:0006783//GO:0006511//GO:0019251//GO:0006351 heme biosynthetic process//ubiquitin-dependent protein catabolic process//anaerobic cobalamin biosynthetic process//transcription, DNA-templated GO:0017111//GO:0016852//GO:0031625//GO:0005524 nucleoside-triphosphatase activity//sirohydrochlorin cobaltochelatase activity//ubiquitin protein ligase binding//ATP binding -- -- KOG2166 Cullins Cluster-8309.41223 BP_3 68.38 6.93 767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41224 BP_3 553.55 5.76 4920 642934662 XP_008197757.1 4110 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X4 [Tribolium castaneum] 766917723 XM_011496118.1 51 9.97945e-15 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 446 2.5e-42 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF08727//PF00595 Poliovirus 3A protein like//PDZ domain (Also known as DHR or GLGF) GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0017111//GO:0005515//GO:0004197//GO:0003968 nucleoside-triphosphatase activity//protein binding//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.41226 BP_3 118.59 1.22 4995 102939 1952 1.5e-215 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1414 1.5e-154 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41227 BP_3 1683.78 15.17 5642 91078042 XP_966587.1 1300 6.6e-140 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 792 2.2e-82 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41228 BP_3 309.79 2.96 5334 642918375 XP_008200060.1 2520 2.1e-281 PREDICTED: ankyrin-2-like isoform X5 [Tribolium castaneum] 836709203 XM_012933675.1 98 8.07768e-41 PREDICTED: Sorex araneus ankyrin 2, neuronal (ANK2), mRNA K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 G5E8K5 1191 1.1e-128 Ankyrin-3 OS=Mus musculus GN=Ank3 PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.41229 BP_3 117.47 3.31 2003 546685505 ERL95003.1 803 1.0e-82 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02106 Fanconi anaemia group C protein GO:0006281 DNA repair -- -- -- -- -- -- Cluster-8309.4123 BP_3 3.00 0.31 762 270017193 EFA13639.1 374 2.1e-33 hypothetical protein TcasGA2_TC005208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NBX4 220 6.3e-17 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41230 BP_3 5.00 3.38 359 546685504 ERL95002.1 152 5.5e-08 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41231 BP_3 1205.16 21.82 2954 91086723 XP_970869.1 1296 1.0e-139 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 7.76752e-09 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 697 1.2e-71 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF05637//PF02535 galactosyl transferase GMA12/MNN10 family//ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0016757//GO:0046873 transferase activity, transferring glycosyl groups//metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2693 Putative zinc transporter Cluster-8309.41232 BP_3 18.54 0.73 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41233 BP_3 31.58 0.54 3102 189234428 XP_001816488.1 3520 0.0e+00 PREDICTED: coatomer subunit beta [Tribolium castaneum]>gi|270001762|gb|EEZ98209.1| hypothetical protein TcasGA2_TC000641 [Tribolium castaneum] 831211679 XM_003781123.2 112 7.71241e-49 PREDICTED: Otolemur garnettii coatomer protein complex, subunit beta 1 (COPB1), mRNA K17301 COPB1, SEC26 coatomer, subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17301 P45437 2857 0.0e+00 Coatomer subunit beta OS=Drosophila melanogaster GN=betaCop PE=2 SV=2 PF01602//PF07718//PF00514//PF02985 Adaptin N terminal region//Coatomer beta C-terminal region//Armadillo/beta-catenin-like repeat//HEAT repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG1058 Vesicle coat complex COPI, beta subunit Cluster-8309.41237 BP_3 28.00 1.03 1602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41239 BP_3 11.00 0.36 1762 478259495 ENN79379.1 747 2.7e-76 hypothetical protein YQE_04172, partial [Dendroctonus ponderosae]>gi|478264859|gb|ENN82347.1| hypothetical protein YQE_01277, partial [Dendroctonus ponderosae] -- -- -- -- -- K07436 CYP24A1 vitamin D3 24-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K07436 Q9VE00 281 1.2e-23 Probable cytochrome P450 12a4, mitochondrial OS=Drosophila melanogaster GN=Cyp12a4 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.41240 BP_3 48.51 0.36 6770 642934282 XP_008200924.1 1145 7.5e-122 PREDICTED: uncharacterized protein LOC103315040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P50748 382 9.2e-35 Kinetochore-associated protein 1 OS=Homo sapiens GN=KNTC1 PE=1 SV=1 PF01125 G10 protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.41242 BP_3 24.00 0.68 1992 751230832 XP_011168942.1 177 3.9e-10 PREDICTED: vascular endothelial growth factor A-like [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.41243 BP_3 509.23 5.14 5064 642935257 XP_008197935.1 1572 1.7e-171 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 429 2.4e-40 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.41244 BP_3 1057.00 13.98 3935 91083595 XP_968896.1 1885 6.8e-208 PREDICTED: autophagy-related protein 9A [Tribolium castaneum]>gi|270006840|gb|EFA03288.1| hypothetical protein TcasGA2_TC013228 [Tribolium castaneum] 642924119 XM_963803.2 67 1.01609e-23 PREDICTED: Tribolium castaneum autophagy-related protein 9A (LOC657338), mRNA K17907 ATG9 autophagy-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K17907 Q3T904 1464 1.8e-160 Autophagy-related protein 9A OS=Bos taurus GN=ATG9A PE=2 SV=1 PF04828 Glutathione-dependent formaldehyde-activating enzyme GO:0008152 metabolic process GO:0016846 carbon-sulfur lyase activity -- -- KOG2173 Integral membrane protein Cluster-8309.41245 BP_3 49.00 0.88 2989 861599296 KMQ83563.1 961 7.1e-101 integrase core domain-containing protein [Lasius niger] -- -- -- -- -- -- -- -- -- P34457 338 5.1e-30 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF08447//PF00665//PF13683 PAS fold//Integrase core domain//Integrase core domain GO:0015074 DNA integration GO:0005515 protein binding -- -- -- -- Cluster-8309.41246 BP_3 3.00 0.76 483 270006141 EFA02589.1 328 2.9e-28 hypothetical protein TcasGA2_TC008308, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS85 165 9.5e-11 Carbonic anhydrase-related protein 10 OS=Homo sapiens GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.41247 BP_3 55.56 0.76 3826 642934677 XP_008197764.1 940 2.5e-98 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X3 [Tribolium castaneum] 642934684 XM_008199547.1 208 4.10347e-102 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 239 2.0e-18 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF01434 Peptidase family M41 GO:0006508 proteolysis GO:0004222//GO:0005524 metalloendopeptidase activity//ATP binding -- -- -- -- Cluster-8309.41248 BP_3 3635.10 57.91 3317 642928315 XP_008195531.1 1039 7.2e-110 PREDICTED: microtubule-associated protein RP/EB family member 1 [Tribolium castaneum] 817062491 XM_012397482.1 89 5.03795e-36 PREDICTED: Athalia rosae microtubule-associated protein RP/EB family member 1 (LOC105684257), transcript variant X6, mRNA K10436 MAPRE microtubule-associated protein, RP/EB family http://www.genome.jp/dbget-bin/www_bget?ko:K10436 Q66T82 749 1.2e-77 Microtubule-associated protein RP/EB family member 1 OS=Coturnix coturnix japonica GN=MAPRE1 PE=2 SV=1 PF06070//PF00307//PF03271//PF05361 Herpesvirus large structural phosphoprotein UL32//Calponin homology (CH) domain//EB1-like C-terminal motif//PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation GO:0008017//GO:0005515//GO:0005198 microtubule binding//protein binding//structural molecule activity GO:0045298//GO:0005737 tubulin complex//cytoplasm KOG3000 Microtubule-binding protein involved in cell cycle control Cluster-8309.41249 BP_3 443.24 7.45 3158 478252036 ENN72467.1 879 2.4e-91 hypothetical protein YQE_10809, partial [Dendroctonus ponderosae] 586460488 XM_006860838.1 137 9.94551e-63 PREDICTED: Chrysochloris asiatica NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (NDUFS8), mRNA K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 P42028 772 2.6e-80 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Bos taurus GN=NDUFS8 PE=1 SV=1 PF03194//PF05187//PF08782 LUC7 N_terminus//Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S//c-SKI Smad4 binding domain GO:0055114//GO:0006376 oxidation-reduction process//mRNA splice site selection GO:0003729//GO:0046332//GO:0004174 mRNA binding//SMAD binding//electron-transferring-flavoprotein dehydrogenase activity GO:0005685 U1 snRNP KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit Cluster-8309.41250 BP_3 367.00 5.69 3399 91078182 XP_967647.1 1956 3.4e-216 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IW92 1045 6.1e-112 Beta-galactosidase-1-like protein 2 OS=Homo sapiens GN=GLB1L2 PE=2 SV=1 PF02449 Beta-galactosidase GO:0046486//GO:0005975//GO:0006687//GO:0006027//GO:0008152//GO:0006012 glycerolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//glycosaminoglycan catabolic process//metabolic process//galactose metabolic process GO:0004565//GO:0004553 beta-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.41253 BP_3 87.96 0.50 8722 -- -- -- -- -- 642938285 XM_008194514.1 89 1.33316e-35 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF09477 Bacterial type II secretion system chaperone protein (type_III_yscG) GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.41256 BP_3 36.00 1.85 1231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41258 BP_3 64.18 0.38 8480 478253916 ENN74208.1 1517 6.8e-165 hypothetical protein YQE_09181, partial [Dendroctonus ponderosae] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9NP71 521 8.8e-51 Carbohydrate-responsive element-binding protein OS=Homo sapiens GN=MLXIPL PE=1 SV=1 PF10186//PF00010//PF00170//PF00595//PF09726//PF13180 Vacuolar sorting 38 and autophagy-related subunit 14//Helix-loop-helix DNA-binding domain//bZIP transcription factor//PDZ domain (Also known as DHR or GLGF)//Transmembrane protein//PDZ domain GO:0006355//GO:0010508 regulation of transcription, DNA-templated//positive regulation of autophagy GO:0043565//GO:0003700//GO:0005515//GO:0046983 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding//protein dimerization activity GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG3582 Mlx interactors and related transcription factors Cluster-8309.41259 BP_3 214.80 2.11 5201 91091932 XP_966409.1 1977 1.9e-218 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 827536550 XM_004921667.2 136 5.91782e-62 PREDICTED: Bombyx mori structural maintenance of chromosomes protein 3 (LOC101736252), mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 O93309 1082 4.8e-116 Structural maintenance of chromosomes protein 3 OS=Xenopus laevis GN=smc3 PE=1 SV=2 PF13304//PF05531//PF00614//PF05440//PF04210 AAA domain, putative AbiEii toxin, Type IV TA system//Nucleopolyhedrovirus P10 protein//Phospholipase D Active site motif//Tetrahydromethanopterin S-methyltransferase subunit B//Tetrahydromethanopterin S-methyltransferase, subunit G GO:0006310//GO:0007062//GO:0030261//GO:0015948//GO:0046656//GO:0006281 DNA recombination//sister chromatid cohesion//chromosome condensation//methanogenesis//folic acid biosynthetic process//DNA repair GO:0030269//GO:0003824//GO:0005524 tetrahydromethanopterin S-methyltransferase activity//catalytic activity//ATP binding GO:0005694//GO:0005634//GO:0019028//GO:0016021 chromosome//nucleus//viral capsid//integral component of membrane KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.41260 BP_3 47.61 0.56 4413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41261 BP_3 267.64 1.63 8196 642927636 XP_008195344.1 4923 0.0e+00 PREDICTED: zinc finger FYVE domain-containing protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGP1 1082 7.5e-116 Zinc finger FYVE domain-containing protein 26 homolog OS=Drosophila melanogaster GN=CG5270 PE=1 SV=3 PF04805//PF02419//PF01363 E10-like protein conserved region//PsbL protein//FYVE zinc finger GO:0015979//GO:0055114 photosynthesis//oxidation-reduction process GO:0016972//GO:0046872 thiol oxidase activity//metal ion binding GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center KOG1811 Predicted Zn2+-binding protein, contains FYVE domain Cluster-8309.41262 BP_3 1187.00 234.11 536 642928380 XP_008192720.1 345 3.4e-30 PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|642928382|ref|XP_008192721.1| PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|270010784|gb|EFA07232.1| hypothetical protein TcasGA2_TC010589 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41263 BP_3 1774.77 31.21 3033 546676276 ERL87322.1 1518 1.9e-165 hypothetical protein D910_04717 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGU5 692 4.6e-71 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF13174//PF13181//PF13414//PF08515//PF13176//PF07688//PF00515//PF13374//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Transforming growth factor beta type I GS-motif//Tetratricopeptide repeat//KaiA domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0007178//GO:0006468//GO:0007623//GO:0009069//GO:0016310 transmembrane receptor protein serine/threonine kinase signaling pathway//protein phosphorylation//circadian rhythm//serine family amino acid metabolic process//phosphorylation GO:0004675//GO:0005524//GO:0005515 transmembrane receptor protein serine/threonine kinase activity//ATP binding//protein binding GO:0016020 membrane -- -- Cluster-8309.41265 BP_3 310.46 1.88 8243 642924594 XP_008194356.1 1523 1.3e-165 PREDICTED: schwannomin-interacting protein 1-like [Tribolium castaneum]>gi|270007957|gb|EFA04405.1| hypothetical protein TcasGA2_TC014704 [Tribolium castaneum] 642924593 XM_008196134.1 273 6.5344e-138 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.5e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.41267 BP_3 186.34 1.27 7339 91083005 XP_974497.1 1587 4.5e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit H [Tribolium castaneum]>gi|270007645|gb|EFA04093.1| hypothetical protein TcasGA2_TC014327 [Tribolium castaneum] -- -- -- -- -- K03247 EIF3H translation initiation factor 3 subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K03247 Q9GV27 1431 2.3e-156 Eukaryotic translation initiation factor 3 subunit H OS=Bombyx mori PE=2 SV=1 PF00622//PF09596//PF07525//PF04961//PF01398 SPRY domain//MamL-1 domain//SOCS box//Formiminotransferase-cyclodeaminase//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0045944//GO:0007219//GO:0044237//GO:0035556 positive regulation of transcription from RNA polymerase II promoter//Notch signaling pathway//cellular metabolic process//intracellular signal transduction GO:0003824//GO:0005515//GO:0003713 catalytic activity//protein binding//transcription coactivator activity GO:0005667//GO:0016607 transcription factor complex//nuclear speck KOG1560 Translation initiation factor 3, subunit h (eIF-3h) Cluster-8309.41268 BP_3 1716.08 11.78 7314 91083005 XP_974497.1 1587 4.5e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit H [Tribolium castaneum]>gi|270007645|gb|EFA04093.1| hypothetical protein TcasGA2_TC014327 [Tribolium castaneum] -- -- -- -- -- K03247 EIF3H translation initiation factor 3 subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K03247 Q9GV27 1431 2.3e-156 Eukaryotic translation initiation factor 3 subunit H OS=Bombyx mori PE=2 SV=1 PF01398//PF04961//PF09596//PF07525 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//MamL-1 domain//SOCS box GO:0035556//GO:0007219//GO:0045944//GO:0044237 intracellular signal transduction//Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0005515//GO:0003713 catalytic activity//protein binding//transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex KOG1560 Translation initiation factor 3, subunit h (eIF-3h) Cluster-8309.41269 BP_3 112.69 8.23 952 642919915 XP_008192123.1 954 1.5e-100 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] 462448440 APGK01008686.1 56 3.11861e-18 Dendroctonus ponderosae Seq01008694, whole genome shotgun sequence -- -- -- -- Q8BIZ1 563 1.3e-56 Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Mus musculus GN=Anks1b PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41270 BP_3 13.81 0.35 2180 270008906 EFA05354.1 1818 2.2e-200 hypothetical protein TcasGA2_TC015519 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1607 2.6e-177 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654//PF02934 Voltage gated chloride channel//GatB/GatE catalytic domain GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247//GO:0016874 voltage-gated chloride channel activity//ligase activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.41271 BP_3 15.53 0.33 2548 642932421 XP_972642.2 1238 4.6e-133 PREDICTED: synaptotagmin-15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P59926 399 3.7e-37 Synaptotagmin-15 OS=Rattus norvegicus GN=Syt15 PE=2 SV=1 PF01299//PF00168 Lysosome-associated membrane glycoprotein (Lamp)//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.41272 BP_3 744.97 13.32 2988 91078814 XP_970649.1 1632 1.1e-178 PREDICTED: ran GTPase-activating protein 1 [Tribolium castaneum]>gi|270003723|gb|EFA00171.1| hypothetical protein TcasGA2_TC002993 [Tribolium castaneum] -- -- -- -- -- K14319 RANGAP1 Ran GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14319 P46060 862 8.9e-91 Ran GTPase-activating protein 1 OS=Homo sapiens GN=RANGAP1 PE=1 SV=1 PF06524//PF13516//PF07834//PF13855//PF04546 NOA36 protein//Leucine Rich repeat//RanGAP1 C-terminal domain//Leucine rich repeat//Sigma-70, non-essential region GO:0006352//GO:0006355//GO:0050794//GO:0007165 DNA-templated transcription, initiation//regulation of transcription, DNA-templated//regulation of cellular process//signal transduction GO:0003700//GO:0016987//GO:0008270//GO:0005515//GO:0003677//GO:0005096 transcription factor activity, sequence-specific DNA binding//sigma factor activity//zinc ion binding//protein binding//DNA binding//GTPase activator activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1909 Ran GTPase-activating protein Cluster-8309.41273 BP_3 533.07 8.92 3172 91078814 XP_970649.1 1634 6.9e-179 PREDICTED: ran GTPase-activating protein 1 [Tribolium castaneum]>gi|270003723|gb|EFA00171.1| hypothetical protein TcasGA2_TC002993 [Tribolium castaneum] -- -- -- -- -- K14319 RANGAP1 Ran GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14319 P46060 862 9.4e-91 Ran GTPase-activating protein 1 OS=Homo sapiens GN=RANGAP1 PE=1 SV=1 PF04546//PF07834//PF13516//PF13855//PF06524 Sigma-70, non-essential region//RanGAP1 C-terminal domain//Leucine Rich repeat//Leucine rich repeat//NOA36 protein GO:0007165//GO:0050794//GO:0006355//GO:0006352 signal transduction//regulation of cellular process//regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0005096//GO:0005515//GO:0008270//GO:0016987//GO:0003700 DNA binding//GTPase activator activity//protein binding//zinc ion binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1909 Ran GTPase-activating protein Cluster-8309.41274 BP_3 69.73 5.74 877 642925292 XP_001814214.2 395 9.0e-36 PREDICTED: uncharacterized protein LOC100142468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41275 BP_3 20.91 0.33 3344 478254773 ENN75009.1 1721 6.0e-189 hypothetical protein YQE_08326, partial [Dendroctonus ponderosae]>gi|546674398|gb|ERL85785.1| hypothetical protein D910_03200 [Dendroctonus ponderosae] 768418305 XM_011551531.1 267 5.70372e-135 PREDICTED: Plutella xylostella serine/threonine-protein phosphatase alpha-2 isoform (LOC105381736), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q6NVU2 1617 2.8e-178 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Xenopus tropicalis GN=ppp1cc PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.41276 BP_3 3546.95 23.17 7669 642917448 XP_008191204.1 2754 2.3e-308 PREDICTED: maternal protein tudor isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25823 542 2.9e-53 Maternal protein tudor OS=Drosophila melanogaster GN=tud PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41278 BP_3 79.00 5.17 1028 642928987 XP_008195646.1 336 7.3e-29 PREDICTED: WD repeat-containing protein 74 [Tribolium castaneum]>gi|270009716|gb|EFA06164.1| hypothetical protein TcasGA2_TC009011 [Tribolium castaneum] -- -- -- -- -- K14841 NSA1, WDR74 ribosome biogenesis protein NSA1 http://www.genome.jp/dbget-bin/www_bget?ko:K14841 Q54FW9 141 1.2e-07 WD repeat-containing protein DDB_G0290555 OS=Dictyostelium discoideum GN=DDB_G0290555 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG3881 Uncharacterized conserved protein Cluster-8309.41280 BP_3 59.71 1.09 2925 642914454 XP_008201683.1 669 5.1e-67 PREDICTED: proteoglycan 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41281 BP_3 50.79 0.47 5517 642925023 XP_008194140.1 3709 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X4 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.74024e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.7e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.41282 BP_3 2810.00 37.61 3893 270013723 EFA10171.1 4273 0.0e+00 hypothetical protein TcasGA2_TC012361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 1184 5.3e-128 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF02460//PF00873 Patched family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane KOG1934 Predicted membrane protein (patched superfamily) Cluster-8309.41283 BP_3 6552.00 117.43 2981 91081489 XP_976188.1 3027 0.0e+00 PREDICTED: V-type proton ATPase catalytic subunit A [Tribolium castaneum]>gi|270006460|gb|EFA02908.1| NtpA [Tribolium castaneum] 751448908 XM_011180358.1 701 0 PREDICTED: Bactrocera cucurbitae V-type proton ATPase catalytic subunit A isoform 2 (LOC105209762), transcript variant X2, mRNA K02145 ATPeV1A, ATP6A V-type H+-transporting ATPase subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02145 O16109 2932 0.0e+00 V-type proton ATPase catalytic subunit A OS=Aedes aegypti GN=VhaA PE=2 SV=2 PF00006//PF00306//PF02874//PF11883 ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, beta-barrel domain//Domain of unknown function (DUF3403) GO:0015986//GO:0015992//GO:0015991//GO:0016310//GO:0046034//GO:0006119//GO:0009069 ATP synthesis coupled proton transport//proton transport//ATP hydrolysis coupled proton transport//phosphorylation//ATP metabolic process//oxidative phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0046961//GO:0046933//GO:0005524//GO:0016820 protein serine/threonine kinase activity//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism//ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033180//GO:0045259//GO:0033178 proton-transporting V-type ATPase, V1 domain//proton-transporting ATP synthase complex//proton-transporting two-sector ATPase complex, catalytic domain KOG1352 Vacuolar H+-ATPase V1 sector, subunit A Cluster-8309.41284 BP_3 20.21 0.46 2395 189240983 XP_966935.2 1213 3.4e-130 PREDICTED: DDB1- and CUL4-associated factor 10 homolog [Tribolium castaneum]>gi|270012997|gb|EFA09445.1| hypothetical protein TcasGA2_TC010660 [Tribolium castaneum] -- -- -- -- -- K11802 WDR32 WD repeat-containing protein 32 http://www.genome.jp/dbget-bin/www_bget?ko:K11802 Q9VAT2 447 9.4e-43 DDB1- and CUL4-associated factor 10 homolog OS=Drosophila melanogaster GN=CG1523 PE=1 SV=1 PF00400//PF08447 WD domain, G-beta repeat//PAS fold -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41285 BP_3 92.26 1.33 3640 478250663 ENN71155.1 1488 6.8e-162 hypothetical protein YQE_12086, partial [Dendroctonus ponderosae]>gi|546677247|gb|ERL88116.1| hypothetical protein D910_05505 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 801 1.3e-83 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF08320//PF00487 PIG-X / PBN1//Fatty acid desaturase GO:0006506//GO:0006629 GPI anchor biosynthetic process//lipid metabolic process -- -- GO:0005789 endoplasmic reticulum membrane KOG0537 Cytochrome b5 Cluster-8309.41286 BP_3 31.81 1.12 1657 91079136 XP_975456.1 331 4.5e-28 PREDICTED: uncharacterized protein LOC664352 [Tribolium castaneum]>gi|270003627|gb|EFA00075.1| hypothetical protein TcasGA2_TC002890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41287 BP_3 36.02 0.53 3562 91076618 XP_969384.1 252 1.4e-18 PREDICTED: trypsin II-P29 [Tribolium castaneum]>gi|270002914|gb|EEZ99361.1| serine protease H59 [Tribolium castaneum] -- -- -- -- -- K09643 TMPRSS13, TMPRSS11 transmembrane protease, serine 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09643 Q9BYE2 181 9.8e-12 Transmembrane protease serine 13 OS=Homo sapiens GN=TMPRSS13 PE=2 SV=4 PF16048//PF00089//PF11057 Frog antimicrobial peptide//Trypsin//Cortexin of kidney GO:0006952//GO:0006508 defense response//proteolysis GO:0004252 serine-type endopeptidase activity GO:0031224//GO:0005576 intrinsic component of membrane//extracellular region -- -- Cluster-8309.41288 BP_3 1.76 0.41 498 642922794 XP_008193328.1 427 9.9e-40 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 255 3.6e-21 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41292 BP_3 281.78 5.74 2657 642930948 XP_008196153.1 1518 1.6e-165 PREDICTED: protein diaphanous isoform X3 [Tribolium castaneum] 642930947 XM_008197931.1 56 8.90462e-18 PREDICTED: Tribolium castaneum protein diaphanous (LOC660495), transcript variant X3, mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 771 2.8e-80 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF10508//PF06371//PF06367 Proteasome non-ATPase 26S subunit//Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain GO:0016043//GO:0030036//GO:0043248 cellular component organization//actin cytoskeleton organization//proteasome assembly GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1924 RhoA GTPase effector DIA/Diaphanous Cluster-8309.41294 BP_3 243.13 29.95 683 642931342 XP_008196538.1 211 1.5e-14 PREDICTED: gametocyte-specific factor 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41295 BP_3 240.00 6.95 1957 642937654 XP_008198887.1 1624 6.2e-178 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum] -- -- -- -- -- K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 Q0VD19 807 1.4e-84 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 PF13085//PF00149 2Fe-2S iron-sulfur cluster binding domain//Calcineurin-like phosphoesterase GO:0006118 obsolete electron transport GO:0016787//GO:0051536//GO:0009055 hydrolase activity//iron-sulfur cluster binding//electron carrier activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.41296 BP_3 733.12 5.11 7202 642936633 XP_008198516.1 3002 0.0e+00 PREDICTED: trafficking kinesin-binding protein milt isoform X1 [Tribolium castaneum]>gi|270013061|gb|EFA09509.1| hypothetical protein TcasGA2_TC011611 [Tribolium castaneum] 642936632 XM_008200294.1 341 9.02192e-176 PREDICTED: Tribolium castaneum trafficking kinesin-binding protein milt (LOC661863), transcript variant X1, mRNA K15369 TRAK1 trafficking kinesin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15369 Q960V3 741 2.3e-76 Trafficking kinesin-binding protein milt OS=Drosophila melanogaster GN=milt PE=1 SV=1 PF06009//PF04111//PF15182//PF04513//PF08702//PF01496//PF02262 Laminin Domain II//Autophagy protein Apg6//Otospiralin//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//V-type ATPase 116kDa subunit family//CBL proto-oncogene N-terminal domain 1 GO:0030168//GO:0007155//GO:0015991//GO:0007166//GO:0015992//GO:0007165//GO:0007605//GO:0051258//GO:0006914 platelet activation//cell adhesion//ATP hydrolysis coupled proton transport//cell surface receptor signaling pathway//proton transport//signal transduction//sensory perception of sound//protein polymerization//autophagy GO:0004871//GO:0030674//GO:0015078//GO:0005102//GO:0005198 signal transducer activity//protein binding, bridging//hydrogen ion transmembrane transporter activity//receptor binding//structural molecule activity GO:0033179//GO:0005634//GO:0019031//GO:0005577//GO:0019028 proton-transporting V-type ATPase, V0 domain//nucleus//viral envelope//fibrinogen complex//viral capsid -- -- Cluster-8309.41297 BP_3 34.47 0.80 2372 478263612 ENN81918.1 2067 3.2e-229 hypothetical protein YQE_01630, partial [Dendroctonus ponderosae] 768432559 XM_011559308.1 120 2.10009e-53 PREDICTED: Plutella xylostella succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (LOC105388405), mRNA K01027 OXCT 3-oxoacid CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K01027 Q9D0K2 1654 1.0e-182 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Mus musculus GN=Oxct1 PE=1 SV=1 PF00816//PF01144 H-NS histone family//Coenzyme A transferase GO:0006355//GO:0008152 regulation of transcription, DNA-templated//metabolic process GO:0003677//GO:0008410 DNA binding//CoA-transferase activity GO:0005622 intracellular KOG3822 Succinyl-CoA:alpha-ketoacid-CoA transferase Cluster-8309.41298 BP_3 10.75 0.40 1579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41299 BP_3 2462.93 36.05 3585 91085847 XP_974980.1 1266 3.7e-136 PREDICTED: LIM and SH3 domain protein F42H10.3 [Tribolium castaneum]>gi|270010142|gb|EFA06590.1| hypothetical protein TcasGA2_TC009504 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34416 689 1.2e-70 LIM and SH3 domain protein F42H10.3 OS=Caenorhabditis elegans GN=F42H10.3 PE=3 SV=3 PF00412//PF00018//PF14604 LIM domain//SH3 domain//Variant SH3 domain -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG1702 Nebulin repeat protein Cluster-8309.41300 BP_3 346.87 4.39 4096 642936999 XP_968421.2 1046 1.4e-110 PREDICTED: 60 kDa SS-A/Ro ribonucleoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42700 350 2.8e-31 60 kDa SS-A/Ro ribonucleoprotein OS=Xenopus laevis GN=trove2 PE=1 SV=1 PF02285//PF05731 Cytochrome oxidase c subunit VIII//TROVE domain GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003723 cytochrome-c oxidase activity//RNA binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.41301 BP_3 471.38 6.06 4041 642936999 XP_968421.2 1046 1.3e-110 PREDICTED: 60 kDa SS-A/Ro ribonucleoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42700 350 2.8e-31 60 kDa SS-A/Ro ribonucleoprotein OS=Xenopus laevis GN=trove2 PE=1 SV=1 PF05731//PF02285 TROVE domain//Cytochrome oxidase c subunit VIII GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003723 cytochrome-c oxidase activity//RNA binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.41305 BP_3 127.21 1.67 3973 642938512 XP_008195463.1 842 6.0e-87 PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum]>gi|642938514|ref|XP_008195504.1| PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00591 COQ3 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00591 Q63159 602 1.7e-60 Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Rattus norvegicus GN=Coq3 PE=2 SV=2 PF03602//PF01209//PF05401//PF08241//PF02527//PF05175//PF00891//PF09445 Conserved hypothetical protein 95//ubiE/COQ5 methyltransferase family//Nodulation protein S (NodS)//Methyltransferase domain//rRNA small subunit methyltransferase G//Methyltransferase small domain//O-methyltransferase//RNA cap guanine-N2 methyltransferase GO:0001510//GO:0009312//GO:0008152//GO:0009452//GO:0031167//GO:0006364//GO:0009877//GO:0006396//GO:0000154 RNA methylation//oligosaccharide biosynthetic process//metabolic process//7-methylguanosine RNA capping//rRNA methylation//rRNA processing//nodulation//RNA processing//rRNA modification GO:0008757//GO:0008171//GO:0008649//GO:0008168 S-adenosylmethionine-dependent methyltransferase activity//O-methyltransferase activity//rRNA methyltransferase activity//methyltransferase activity GO:0005737 cytoplasm KOG1270 Methyltransferases Cluster-8309.41306 BP_3 558.90 11.20 2696 91090278 XP_970876.1 767 2.0e-78 PREDICTED: cell division control protein 42 homolog [Tribolium castaneum]>gi|270014293|gb|EFA10741.1| hypothetical protein TcasGA2_TC012434 [Tribolium castaneum] -- -- -- -- -- K07865 RHOU, WRCH1 Ras homolog gene family, member U http://www.genome.jp/dbget-bin/www_bget?ko:K07865 Q9EQT3 457 7.3e-44 Rho-related GTP-binding protein RhoU OS=Mus musculus GN=Rhou PE=2 SV=1 PF01926//PF03193//PF08477//PF00025//PF00071 50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0005622//GO:0016020 intracellular//membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.41307 BP_3 384.14 3.31 5887 642935247 XP_008197929.1 4988 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 773 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1799 3.9e-199 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF16656//PF00041//PF13895//PF05506//PF01213 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//Domain of unknown function (DUF756)//Adenylate cyclase associated (CAP) N terminal GO:0006771//GO:0016042//GO:0009395//GO:0007010//GO:0019497 riboflavin metabolic process//lipid catabolic process//phospholipid catabolic process//cytoskeleton organization//hexachlorocyclohexane metabolic process GO:0003993//GO:0004629//GO:0046872//GO:0005515//GO:0003779 acid phosphatase activity//phospholipase C activity//metal ion binding//protein binding//actin binding -- -- -- -- Cluster-8309.41309 BP_3 8.00 4.26 380 657792115 XP_008322921.1 256 5.1e-20 PREDICTED: zinc finger MYM-type protein 1-like [Cynoglossus semilaevis] -- -- -- -- -- -- -- -- -- Q5SVZ6 121 9.4e-06 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4131 BP_3 3.00 0.79 475 642931265 XP_008196504.1 188 4.9e-12 PREDICTED: high mobility group B protein 13-like [Tribolium castaneum]>gi|270012132|gb|EFA08580.1| hypothetical protein TcasGA2_TC006235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41312 BP_3 52.27 0.85 3266 642919300 XP_008191816.1 1453 6.9e-158 PREDICTED: UDP-glucuronosyltransferase 1-7C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64634 648 6.3e-66 UDP-glucuronosyltransferase 1-8 OS=Rattus norvegicus GN=Ugt1a8 PE=2 SV=1 PF04101//PF13409//PF02419//PF00201 Glycosyltransferase family 28 C-terminal domain//Glutathione S-transferase, N-terminal domain//PsbL protein//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152//GO:0015979 metabolic process//photosynthesis GO:0016758//GO:0005515 transferase activity, transferring hexosyl groups//protein binding GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.41313 BP_3 182.03 3.13 3091 642919300 XP_008191816.1 1453 6.6e-158 PREDICTED: UDP-glucuronosyltransferase 1-7C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64634 648 6.0e-66 UDP-glucuronosyltransferase 1-8 OS=Rattus norvegicus GN=Ugt1a8 PE=2 SV=1 PF13409//PF00201//PF04101 Glutathione S-transferase, N-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0005515//GO:0016758 protein binding//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.41314 BP_3 2027.00 27.86 3798 642915122 XP_008190418.1 736 1.1e-74 PREDICTED: uncharacterized protein LOC103312186 [Tribolium castaneum]>gi|270002873|gb|EEZ99320.1| bifocal [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03410 Metallopeptidase from vaccinia pox GO:0019058 viral life cycle GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.41316 BP_3 41.99 0.91 2512 91080341 XP_974659.1 557 4.2e-54 PREDICTED: ADP-ribosylation factor GTPase-activating protein 2 [Tribolium castaneum]>gi|270005715|gb|EFA02163.1| hypothetical protein TcasGA2_TC007817 [Tribolium castaneum] -- -- -- -- -- K12493 ARFGAP2_3 ADP-ribosylation factor GTPase-activating protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12493 Q17R07 270 3.3e-22 ADP-ribosylation factor GTPase-activating protein 3 OS=Bos taurus GN=ARFGAP3 PE=2 SV=1 PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- KOG0706 Predicted GTPase-activating protein Cluster-8309.41318 BP_3 94.19 7.15 927 642923010 XP_973133.3 600 1.6e-59 PREDICTED: transcription factor GATA-4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41319 BP_3 124.82 2.32 2887 642924612 XP_008194363.1 852 3.0e-88 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41320 BP_3 10.00 1.71 574 189238487 XP_969483.2 303 2.7e-25 PREDICTED: trichoplein keratin filament-binding protein-like [Tribolium castaneum] -- -- -- -- -- K16811 TCHP trichoplein keratin filament-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K16811 Q1RM03 136 2.6e-07 Trichoplein keratin filament-binding protein OS=Danio rerio GN=tchp PE=2 SV=1 PF05279//PF13304 Aspartyl beta-hydroxylase N-terminal region//AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding GO:0016020 membrane -- -- Cluster-8309.41321 BP_3 445.45 3.96 5708 642925019 XP_008194138.1 3847 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X2 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.97512e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.8e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.41322 BP_3 116.86 3.43 1933 749747448 XP_011135848.1 1108 4.2e-118 PREDICTED: casein kinase II subunit beta isoform X1 [Harpegnathos saltator] 642914880 XM_961220.2 352 0 PREDICTED: Tribolium castaneum casein kinase II subunit beta (LOC658630), transcript variant X1, mRNA K03115 CSNK2B casein kinase II subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03115 O76485 1031 1.5e-110 Casein kinase II subunit beta OS=Spodoptera frugiperda PE=2 SV=1 PF01214 Casein kinase II regulatory subunit GO:0045859 regulation of protein kinase activity GO:0019887 protein kinase regulator activity GO:0005956 protein kinase CK2 complex KOG3092 Casein kinase II, beta subunit Cluster-8309.41323 BP_3 1472.80 44.84 1875 749747448 XP_011135848.1 1108 4.0e-118 PREDICTED: casein kinase II subunit beta isoform X1 [Harpegnathos saltator] 642914880 XM_961220.2 352 0 PREDICTED: Tribolium castaneum casein kinase II subunit beta (LOC658630), transcript variant X1, mRNA K03115 CSNK2B casein kinase II subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03115 O76485 1031 1.4e-110 Casein kinase II subunit beta OS=Spodoptera frugiperda PE=2 SV=1 PF01214 Casein kinase II regulatory subunit GO:0045859 regulation of protein kinase activity GO:0019887 protein kinase regulator activity GO:0005956 protein kinase CK2 complex KOG3092 Casein kinase II, beta subunit Cluster-8309.41324 BP_3 245.74 9.03 1603 478255841 ENN76049.1 1283 1.8e-138 hypothetical protein YQE_07422, partial [Dendroctonus ponderosae] -- -- -- -- -- K08669 HTRA2, PRSS25 HtrA serine peptidase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08669 B4JTT7 1093 7.8e-118 Serine protease HTRA2, mitochondrial OS=Drosophila grimshawi GN=HtrA2 PE=3 SV=1 PF00089//PF05579//PF00595//PF10459//PF13180 Trypsin//Equine arteritis virus serine endopeptidase S32//PDZ domain (Also known as DHR or GLGF)//Peptidase S46//PDZ domain GO:0006508//GO:0016032//GO:0019082 proteolysis//viral process//viral protein processing GO:0070009//GO:0008239//GO:0005515//GO:0004252 serine-type aminopeptidase activity//dipeptidyl-peptidase activity//protein binding//serine-type endopeptidase activity -- -- KOG1320 Serine protease Cluster-8309.41328 BP_3 3210.44 16.53 9651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41329 BP_3 573.00 46.55 885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41330 BP_3 98.22 0.45 10926 642937913 XP_972695.3 1638 8.2e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.5e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41331 BP_3 195.46 0.85 11314 642937913 XP_972695.3 1638 8.5e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.6e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41332 BP_3 133.51 3.53 2116 91092598 XP_970550.1 686 3.9e-69 PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|642921812|ref|XP_008199330.1| PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|270006629|gb|EFA03077.1| hypothetical protein TcasGA2_TC010951 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q8NEJ0 361 7.8e-33 Dual specificity protein phosphatase 18 OS=Homo sapiens GN=DUSP18 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0016311//GO:0006470//GO:0006570 dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0016791//GO:0004725//GO:0008138 phosphatase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1718 Dual specificity phosphatase Cluster-8309.41333 BP_3 56.00 1.37 2259 546681148 ERL91298.1 756 3.2e-77 hypothetical protein D910_08631 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4USX2 130 5.1e-06 Serpin B10 OS=Otolemur garnettii GN=SERPINB10 PE=3 SV=1 PF02914 Bacteriophage Mu transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-8309.41336 BP_3 48.38 0.49 5097 642929846 XP_008195999.1 1855 2.6e-204 PREDICTED: anoctamin-8 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q9HCE9 524 2.4e-51 Anoctamin-8 OS=Homo sapiens GN=ANO8 PE=1 SV=3 PF15724 TMEM119 family GO:0001503 ossification -- -- -- -- KOG2513 Protein required for meiotic chromosome segregation Cluster-8309.41338 BP_3 1349.51 13.31 5179 646722544 KDR23502.1 4689 0.0e+00 Dual oxidase 2 [Zootermopsis nevadensis] -- -- -- -- -- K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9NRD9 2752 1.1e-309 Dual oxidase 1 OS=Homo sapiens GN=DUOX1 PE=1 SV=1 PF12763//PF00175//PF13499//PF13833//PF13405//PF13202//PF08030//PF03185//PF15048//PF08022//PF00036 Cytoskeletal-regulatory complex EF hand//Oxidoreductase NAD-binding domain//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Ferric reductase NAD binding domain//Calcium-activated potassium channel, beta subunit//Organic solute transporter subunit beta protein//FAD-binding domain//EF hand GO:0006813//GO:0006810//GO:0015721//GO:0055114 potassium ion transport//transport//bile acid and bile salt transport//oxidation-reduction process GO:0005215//GO:0015269//GO:0016491//GO:0046982//GO:0005515//GO:0005509 transporter activity//calcium-activated potassium channel activity//oxidoreductase activity//protein heterodimerization activity//protein binding//calcium ion binding GO:0005886//GO:0016020 plasma membrane//membrane KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.41341 BP_3 549.59 2.29 11839 270015748 EFA12196.1 1838 5.7e-202 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TT16 248 5.5e-19 Inositol polyphosphate multikinase OS=Mus musculus GN=Ipmk PE=2 SV=1 PF01218//PF08702//PF01105//PF00642//PF10473//PF03938//PF13912//PF05529//PF16716//PF00096//PF00867//PF03770//PF04111//PF00695 Coproporphyrinogen III oxidase//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Outer membrane protein (OmpH-like)//C2H2-type zinc finger//B-cell receptor-associated protein 31-like//Bone marrow stromal antigen 2//Zinc finger, C2H2 type//XPG I-region//Inositol polyphosphate kinase//Autophagy protein Apg6//Major surface antigen from hepadnavirus GO:0006810//GO:0006886//GO:0006914//GO:0051258//GO:0007165//GO:0006779//GO:0055114//GO:0015994//GO:0051607//GO:0016032//GO:0030168 transport//intracellular protein transport//autophagy//protein polymerization//signal transduction//porphyrin-containing compound biosynthetic process//oxidation-reduction process//chlorophyll metabolic process//defense response to virus//viral process//platelet activation GO:0045502//GO:0008134//GO:0005102//GO:0008440//GO:0051082//GO:0004109//GO:0046872//GO:0004518//GO:0042803//GO:0030674 dynein binding//transcription factor binding//receptor binding//inositol-1,4,5-trisphosphate 3-kinase activity//unfolded protein binding//coproporphyrinogen oxidase activity//metal ion binding//nuclease activity//protein homodimerization activity//protein binding, bridging GO:0016021//GO:0005577//GO:0005783//GO:0005667//GO:0030286 integral component of membrane//fibrinogen complex//endoplasmic reticulum//transcription factor complex//dynein complex -- -- Cluster-8309.41342 BP_3 46.41 0.67 3609 642940455 XP_972983.2 926 9.9e-97 PREDICTED: tektin-1 [Tribolium castaneum]>gi|642940457|ref|XP_008196454.1| PREDICTED: tektin-1 [Tribolium castaneum] 768916438 XR_964517.1 62 5.60399e-21 PREDICTED: Takifugu rubripes cytochrome c oxidase assembly protein COX15 homolog (LOC101068591), transcript variant X2, misc_RNA K02259 COX15 cytochrome c oxidase assembly protein subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K02259 Q08DG6 598 4.4e-60 Cytochrome c oxidase assembly protein COX15 homolog OS=Bos taurus GN=COX15 PE=2 SV=1 PF01544//PF02185//PF04799//PF02628//PF00944 CorA-like Mg2+ transporter protein//Hr1 repeat//fzo-like conserved region//Cytochrome oxidase assembly protein//Alphavirus core protein GO:0006784//GO:0055114//GO:0008053//GO:0006508//GO:0007165//GO:0030001//GO:0055085 heme a biosynthetic process//oxidation-reduction process//mitochondrial fusion//proteolysis//signal transduction//metal ion transport//transmembrane transport GO:0016627//GO:0004252//GO:0046873//GO:0003924 oxidoreductase activity, acting on the CH-CH group of donors//serine-type endopeptidase activity//metal ion transmembrane transporter activity//GTPase activity GO:0005741//GO:0016020//GO:0016021 mitochondrial outer membrane//membrane//integral component of membrane KOG2725 Cytochrome oxidase assembly factor COX15 Cluster-8309.41344 BP_3 101.54 1.19 4407 189240839 XP_001812334.1 2664 3.5e-298 PREDICTED: SWI/SNF complex subunit SMARCC2 [Tribolium castaneum]>gi|270013718|gb|EFA10166.1| hypothetical protein TcasGA2_TC012356 [Tribolium castaneum] 585702584 XM_006897683.1 41 3.23505e-09 PREDICTED: Elephantulus edwardii SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), mRNA K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q8TAQ2 1626 3.4e-179 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens GN=SMARCC2 PE=1 SV=1 PF07460//PF04433 NUMOD3 motif (2 copies)//SWIRM domain -- -- GO:0005515//GO:0003677//GO:0005488 protein binding//DNA binding//binding -- -- KOG1279 Chromatin remodeling factor subunit and related transcription factors Cluster-8309.41345 BP_3 436.69 8.49 2770 237681162 NP_001153726.1 932 1.5e-97 glyoxylate reductase/hydroxypyruvate reductase-like [Tribolium castaneum]>gi|270012386|gb|EFA08834.1| LOW QUALITY PROTEIN: hypothetical protein TcasGA2_TC006532 [Tribolium castaneum] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 546 3.6e-54 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF03435//PF00389//PF02826//PF03446 Saccharopine dehydrogenase NADP binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0019521//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//metabolic process//pentose-phosphate shunt GO:0005488//GO:0004616//GO:0051287//GO:0016616//GO:0016491 binding//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.41346 BP_3 1306.00 14.59 4607 91086043 XP_973506.1 3181 0.0e+00 PREDICTED: transmembrane protein 245 [Tribolium castaneum]>gi|270010191|gb|EFA06639.1| hypothetical protein TcasGA2_TC009562 [Tribolium castaneum] 752866659 XM_011271529.1 35 7.32307e-06 PREDICTED: Camponotus floridanus transmembrane protein 245 (LOC105259540), transcript variant X3, mRNA -- -- -- -- Q9H330 868 2.8e-91 Transmembrane protein 245 OS=Homo sapiens GN=TMEM245 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2365 Uncharacterized membrane protein Cluster-8309.41347 BP_3 719.53 3.41 10457 642925384 XP_008194526.1 9484 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [Tribolium castaneum] 815805023 XM_012367811.1 81 4.47872e-31 PREDICTED: Linepithema humile transcription-associated protein 1 (LOC105672707), mRNA K08874 TRRAP transformation/transcription domain-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08874 Q9Y4A5 5859 0.0e+00 Transformation/transcription domain-associated protein OS=Homo sapiens GN=TRRAP PE=1 SV=3 PF13414//PF02259//PF13181//PF04065 TPR repeat//FAT domain//Tetratricopeptide repeat//Not1 N-terminal domain, CCR4-Not complex component GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0889 Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily Cluster-8309.41348 BP_3 97.00 6.92 967 270016375 EFA12821.1 269 4.0e-21 hypothetical protein TcasGA2_TC001888 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41349 BP_3 257.99 2.09 6236 332373884 AEE62083.1 1889 3.7e-208 unknown [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.1164e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.7e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF03650//PF01435//PF00400//PF03598 Uncharacterised protein family (UPF0041)//Peptidase family M48//WD domain, G-beta repeat//CO dehydrogenase/acetyl-CoA synthase complex beta subunit GO:0006508//GO:0015947//GO:0006084//GO:0006850 proteolysis//methane metabolic process//acetyl-CoA metabolic process//mitochondrial pyruvate transport GO:0018492//GO:0004222//GO:0005515 carbon-monoxide dehydrogenase (acceptor) activity//metalloendopeptidase activity//protein binding GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.41351 BP_3 26.73 0.44 3237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41354 BP_3 363.00 4.21 4446 478261169 ENN80698.1 3079 0.0e+00 hypothetical protein YQE_02881, partial [Dendroctonus ponderosae] 549438548 KC282406.1 75 4.10434e-28 Leptinotarsa decemlineata clone 13-6555 heat shock protein mRNA, partial cds K09486 HYOU1 hypoxia up-regulated 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09486 Q9JKR6 1870 1.7e-207 Hypoxia up-regulated protein 1 OS=Mus musculus GN=Hyou1 PE=1 SV=1 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0104 Molecular chaperones GRP170/SIL1, HSP70 superfamily Cluster-8309.41356 BP_3 13639.26 964.98 973 195453696 XP_002073900.1 1480 1.5e-161 GK14362 [Drosophila willistoni]>gi|194169985|gb|EDW84886.1| GK14362 [Drosophila willistoni] 803322942 XM_012164297.1 470 0 PREDICTED: Ovis aries musimon tubulin alpha-3 chain (LOC101108295), transcript variant X3, mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q71U36 1476 1.8e-162 Tubulin alpha-1A chain OS=Homo sapiens GN=TUBA1A PE=1 SV=1 PF00091//PF04928//PF14820//PF00706 Tubulin/FtsZ family, GTPase domain//Poly(A) polymerase central domain//Small proline-rich 2//Anenome neurotoxin GO:0043631//GO:0009966//GO:0007018//GO:0051258//GO:0006184 RNA polyadenylation//regulation of signal transduction//microtubule-based movement//protein polymerization//obsolete GTP catabolic process GO:0004652//GO:0003924//GO:0005198//GO:0005525 polynucleotide adenylyltransferase activity//GTPase activity//structural molecule activity//GTP binding GO:0005874//GO:0005576//GO:0005737//GO:0001533 microtubule//extracellular region//cytoplasm//cornified envelope KOG1376 Alpha tubulin Cluster-8309.41358 BP_3 711.54 6.38 5666 642923519 XP_008193543.1 1676 1.7e-183 PREDICTED: coiled-coil domain-containing protein 6 isoform X1 [Tribolium castaneum] 817195200 XM_012417714.1 198 2.20795e-96 PREDICTED: Orussus abietinus coiled-coil domain-containing protein 6 (LOC105695793), mRNA K09288 CCDC6, PTC coiled-coil domain-containing protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09288 Q16204 962 4.3e-102 Coiled-coil domain-containing protein 6 OS=Homo sapiens GN=CCDC6 PE=1 SV=2 PF04434//PF04647//PF04551 SWIM zinc finger//Accessory gene regulator B//GcpE protein GO:0016114//GO:0009405//GO:0055114//GO:0009372 terpenoid biosynthetic process//pathogenesis//oxidation-reduction process//quorum sensing GO:0046429//GO:0008233//GO:0008270 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//peptidase activity//zinc ion binding GO:0016021 integral component of membrane KOG2129 Uncharacterized conserved protein H4 Cluster-8309.41359 BP_3 7.30 0.32 1398 91090714 XP_975034.1 548 2.6e-53 PREDICTED: 27 kDa hemolymph protein [Tribolium castaneum]>gi|270013294|gb|EFA09742.1| hypothetical protein TcasGA2_TC011877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 246 1.1e-19 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41360 BP_3 227.56 3.00 3942 189235679 XP_971393.2 226 1.6e-15 PREDICTED: sperm surface protein Sp17 [Tribolium castaneum]>gi|270004446|gb|EFA00894.1| hypothetical protein TcasGA2_TC003798 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41361 BP_3 469.31 2.50 9336 642926973 XP_008195085.1 2249 9.9e-250 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 1.0e-76 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF00621//PF06206//PF05791//PF03650//PF10186//PF08031 RhoGEF domain//CpeT/CpcT family (DUF1001)//Bacillus haemolytic enterotoxin (HBL)//Uncharacterised protein family (UPF0041)//Vacuolar sorting 38 and autophagy-related subunit 14//Berberine and berberine like GO:0010508//GO:0017009//GO:0055114//GO:0043087//GO:0006850//GO:0009405//GO:0035023 positive regulation of autophagy//protein-phycocyanobilin linkage//oxidation-reduction process//regulation of GTPase activity//mitochondrial pyruvate transport//pathogenesis//regulation of Rho protein signal transduction GO:0005089//GO:0050660//GO:0016491 Rho guanyl-nucleotide exchange factor activity//flavin adenine dinucleotide binding//oxidoreductase activity GO:0016020//GO:0005743 membrane//mitochondrial inner membrane -- -- Cluster-8309.41362 BP_3 200.84 9.61 1299 146432689 ABQ41245.1 359 2.0e-31 male reproductive-related LIM protein [Macrobrachium rosenbergii] 525346489 KC793960.1 52 7.18319e-16 Scylla paramamosain clone Scpa68 microsatellite sequence K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 262 1.4e-21 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00096//PF02150//PF00412//PF08063 Zinc finger, C2H2 type//RNA polymerases M/15 Kd subunit//LIM domain//PADR1 (NUC008) domain GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0003950//GO:0046872//GO:0008270//GO:0003899//GO:0003677 NAD+ ADP-ribosyltransferase activity//metal ion binding//zinc ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.41363 BP_3 1850.57 154.52 869 150416593 ABF60889.2 161 1.2e-08 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07941 Potassium channel Kv1.4 tandem inactivation domain GO:0006813 potassium ion transport GO:0030955//GO:0005249 potassium ion binding//voltage-gated potassium channel activity GO:0016021//GO:0008076 integral component of membrane//voltage-gated potassium channel complex -- -- Cluster-8309.41364 BP_3 176.96 3.04 3096 642927514 XP_008195300.1 1933 1.4e-213 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] 170047638 XM_001851269.1 219 2.54312e-108 Culex quinquefasciatus conserved hypothetical protein, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 A1L1G1 994 4.5e-106 Epithelial splicing regulatory protein 1 OS=Danio rerio GN=esrp1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.41365 BP_3 16.88 0.49 1945 270014340 EFA10788.1 281 3.3e-22 hypothetical protein TcasGA2_TC012758 [Tribolium castaneum] -- -- -- -- -- K12384 SCARB2, LIMP2, CD36L2 lysosome membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12384 Q27367 194 1.7e-13 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF08091//PF01130 Spider insecticidal peptide//CD36 family GO:0007155//GO:0009405 cell adhesion//pathogenesis -- -- GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.41366 BP_3 21.49 0.52 2295 478250852 ENN71341.1 953 4.6e-100 hypothetical protein YQE_11956, partial [Dendroctonus ponderosae]>gi|546678340|gb|ERL88982.1| hypothetical protein D910_06360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VPK7 555 2.7e-55 Putative tRNA pseudouridine synthase Pus10 OS=Drosophila melanogaster GN=Pus10 PE=2 SV=2 PF02058//PF01416 Guanylin precursor//tRNA pseudouridine synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0009982//GO:0003723//GO:0030250 pseudouridine synthase activity//RNA binding//guanylate cyclase activator activity GO:0005576 extracellular region KOG2364 Predicted pseudouridylate synthase Cluster-8309.41367 BP_3 53.54 4.49 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02096 60Kd inner membrane protein GO:0051205 protein insertion into membrane -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41370 BP_3 1126.09 15.06 3896 642932512 XP_008197144.1 2807 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum]>gi|642932514|ref|XP_008197145.1| PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum] 642932517 XM_008198925.1 651 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 P32023 2359 3.0e-264 cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 OS=Drosophila melanogaster GN=for PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.41372 BP_3 40.63 5.69 636 642931959 XP_008196795.1 248 7.2e-19 PREDICTED: tRNA-splicing endonuclease subunit Sen54-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C2A2 138 1.7e-07 tRNA-splicing endonuclease subunit Sen54 OS=Mus musculus GN=Tsen54 PE=2 SV=2 PF02778 tRNA intron endonuclease, N-terminal domain GO:0051252//GO:0006388 regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0000213 tRNA-intron endonuclease activity GO:0000214 tRNA-intron endonuclease complex -- -- Cluster-8309.41376 BP_3 129.39 1.68 3993 642932217 XP_008194627.1 1114 1.7e-118 PREDICTED: protein spinster isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GQQ0 813 5.7e-85 Protein spinster OS=Drosophila melanogaster GN=spin PE=1 SV=1 PF03137//PF00335 Organic Anion Transporter Polypeptide (OATP) family//Tetraspanin family GO:0006810 transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1330 Sugar transporter/spinster transmembrane protein Cluster-8309.41378 BP_3 2025.94 28.41 3729 91075966 XP_969306.1 1289 8.3e-139 PREDICTED: electron transfer flavoprotein subunit alpha, mitochondrial [Tribolium castaneum]>gi|270014657|gb|EFA11105.1| hypothetical protein TcasGA2_TC004703 [Tribolium castaneum] -- -- -- -- -- K03522 fixB, etfA electron transfer flavoprotein alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03522 P13803 1016 1.5e-108 Electron transfer flavoprotein subunit alpha, mitochondrial OS=Rattus norvegicus GN=Etfa PE=1 SV=4 PF15453//PF02796//PF04218//PF03184 Protein incorporated later into Tight Junctions//Helix-turn-helix domain of resolvase//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease GO:0006310//GO:0006118 DNA recombination//obsolete electron transport GO:0003677//GO:0000150//GO:0050660//GO:0003676//GO:0009055 DNA binding//recombinase activity//flavin adenine dinucleotide binding//nucleic acid binding//electron carrier activity GO:0005923 bicellular tight junction KOG3954 Electron transfer flavoprotein, alpha subunit Cluster-8309.41380 BP_3 62.00 2.64 1423 -- -- -- -- -- 86515329 NM_001039401.1 71 2.16231e-26 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41382 BP_3 179.51 1.95 4720 -- -- -- -- -- 86515329 NM_001039401.1 63 2.04261e-21 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.41384 BP_3 3837.98 49.99 3992 642923280 XP_008193688.1 2173 2.8e-241 PREDICTED: long-chain fatty acid transport protein 4 [Tribolium castaneum] -- -- -- -- -- K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K08745 Q6P1M0 1350 3.1e-147 Long-chain fatty acid transport protein 4 OS=Homo sapiens GN=SLC27A4 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.41385 BP_3 53.74 0.65 4297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.41386 BP_3 108.46 1.94 2990 270003147 EEZ99594.1 759 1.9e-77 hypothetical protein TcasGA2_TC001581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41387 BP_3 34.00 0.99 1941 641657806 XP_008180482.1 398 8.9e-36 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16590 Exocrine gland-secreting peptide GO:0007165 signal transduction GO:0005186 pheromone activity GO:0005615 extracellular space -- -- Cluster-8309.41388 BP_3 1630.30 20.90 4051 332373348 AEE61815.1 1592 6.6e-174 unknown [Dendroctonus ponderosae] 769840408 XM_011633076.1 188 5.70343e-91 PREDICTED: Pogonomyrmex barbatus probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (LOC105423352), transcript variant X2, mRNA K00161 PDHA, pdhA pyruvate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00161 P26268 1220 3.7e-132 Pyruvate dehydrogenase E1 component subunit alpha type II, mitochondrial (Fragment) OS=Ascaris suum PE=2 SV=1 PF02775//PF09029//PF00676//PF13292 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//5-aminolevulinate synthase presequence//Dehydrogenase E1 component//1-deoxy-D-xylulose-5-phosphate synthase GO:0006563//GO:0016114//GO:0042967//GO:0006566//GO:0006778//GO:0006694//GO:0008152//GO:0006544//GO:0006783 L-serine metabolic process//terpenoid biosynthetic process//acyl-carrier-protein biosynthetic process//threonine metabolic process//porphyrin-containing compound metabolic process//steroid biosynthetic process//metabolic process//glycine metabolic process//heme biosynthetic process GO:0008661//GO:0016624//GO:0003824//GO:0030170//GO:0003870//GO:0030976 1-deoxy-D-xylulose-5-phosphate synthase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity//pyridoxal phosphate binding//5-aminolevulinate synthase activity//thiamine pyrophosphate binding GO:0005759 mitochondrial matrix KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.41389 BP_3 644.45 17.80 2037 478250623 ENN71115.1 494 6.9e-47 hypothetical protein YQE_12048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0030431//GO:1903818//GO:0032222 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.41391 BP_3 42.32 1.07 2196 642919379 XP_008191847.1 1572 7.4e-172 PREDICTED: vascular endothelial growth factor receptor 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 645 9.5e-66 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF13895//PF00069//PF06293//PF07714 Immunoglobulin domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0005515//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.41392 BP_3 7.90 0.59 935 646713645 KDR17927.1 356 3.2e-31 hypothetical protein L798_08003 [Zootermopsis nevadensis] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 145 3.8e-08 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41393 BP_3 1735.00 35.64 2638 512923828 XP_004930447.1 1539 6.0e-168 PREDICTED: 25S rRNA (cytosine-C(5))-methyltransferase nop2 [Bombyx mori] -- -- -- -- -- K14835 NOP2 ribosomal RNA methyltransferase Nop2 http://www.genome.jp/dbget-bin/www_bget?ko:K14835 Q922K7 1301 9.7e-142 Probable 28S rRNA (cytosine-C(5))-methyltransferase OS=Mus musculus GN=Nop2 PE=1 SV=1 PF01189//PF01269 16S rRNA methyltransferase RsmF//Fibrillarin GO:0008033//GO:0006364 tRNA processing//rRNA processing GO:0003723//GO:0008168 RNA binding//methyltransferase activity -- -- KOG1122 tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) Cluster-8309.41394 BP_3 6.21 0.44 970 646713645 KDR17927.1 356 3.3e-31 hypothetical protein L798_08003 [Zootermopsis nevadensis] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 145 4.0e-08 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41395 BP_3 1770.91 32.56 2913 642915738 XP_008190784.1 4283 0.0e+00 PREDICTED: kalirin isoform X3 [Tribolium castaneum] 642915737 XM_008192562.1 954 0 PREDICTED: Tribolium castaneum kalirin (LOC656919), transcript variant X3, mRNA K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 2426 3.8e-272 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF16590//PF00435//PF00018//PF14604//PF00621 Exocrine gland-secreting peptide//Spectrin repeat//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0007165//GO:0043087//GO:0035023 signal transduction//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005186//GO:0005089//GO:0005515 pheromone activity//Rho guanyl-nucleotide exchange factor activity//protein binding GO:0005615 extracellular space KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.41396 BP_3 929.58 12.26 3945 642915736 XP_008190782.1 4668 0.0e+00 PREDICTED: kalirin isoform X2 [Tribolium castaneum] 462304009 APGK01049651.1 110 1.27197e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 Q1LUA6 860 2.0e-90 Triple functional domain protein OS=Danio rerio GN=trio PE=3 SV=1 PF13895//PF00041//PF00621//PF00069//PF02899//PF07714 Immunoglobulin domain//Fibronectin type III domain//RhoGEF domain//Protein kinase domain//Phage integrase, N-terminal SAM-like domain//Protein tyrosine kinase GO:0035023//GO:0006468//GO:0043087//GO:0015074 regulation of Rho protein signal transduction//protein phosphorylation//regulation of GTPase activity//DNA integration GO:0005524//GO:0003677//GO:0005515//GO:0005089//GO:0004672 ATP binding//DNA binding//protein binding//Rho guanyl-nucleotide exchange factor activity//protein kinase activity -- -- -- -- Cluster-8309.41399 BP_3 74.68 8.23 729 189239014 XP_974755.2 558 9.4e-55 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 221 4.6e-17 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41401 BP_3 64.82 0.48 6769 642920612 XP_008192488.1 1042 6.6e-110 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- -- -- Cluster-8309.41402 BP_3 599.73 13.98 2360 642921254 XP_008192785.1 1488 4.4e-162 PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|642921256|ref|XP_008192787.1| PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|270006236|gb|EFA02684.1| hypothetical protein TcasGA2_TC008405 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q02790 1051 8.5e-113 Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens GN=FKBP4 PE=1 SV=3 PF13181//PF13174//PF00515//PF13371//PF04434//PF13176//PF00254//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//SWIM zinc finger//Tetratricopeptide repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//TPR repeat GO:0006457 protein folding GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.41403 BP_3 8.00 0.43 1199 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41404 BP_3 2075.58 10.34 9966 642914147 XP_008201565.1 9361 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1238 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.1e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.41405 BP_3 44.31 0.92 2603 478251412 ENN71878.1 726 1.1e-73 hypothetical protein YQE_11493, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M882 217 4.8e-16 Ribonuclease P protein subunit p29 OS=Rattus norvegicus GN=Pop4 PE=2 SV=1 PF01868 Domain of unknown function UPF0086 GO:0051252//GO:0008033//GO:0006364//GO:0006379 regulation of RNA metabolic process//tRNA processing//rRNA processing//mRNA cleavage GO:0004540//GO:0003723 ribonuclease activity//RNA binding GO:0000172//GO:0030677 ribonuclease MRP complex//ribonuclease P complex KOG4046 RNase MRP and P, subunit POP4/p29 Cluster-8309.41406 BP_3 15.00 0.46 1872 642917429 XP_008191194.1 1665 1.0e-182 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P84850 1303 4.1e-142 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=D2hgdh PE=3 SV=1 PF01565//PF02913 FAD binding domain//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0050660//GO:0003824 oxidoreductase activity//flavin adenine dinucleotide binding//catalytic activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.41409 BP_3 15.56 0.32 2601 642928001 XP_008195479.1 4189 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] 642928000 XM_008197257.1 898 0 PREDICTED: Tribolium castaneum neurexin-1 (LOC663759), mRNA K07377 NRXN neurexin http://www.genome.jp/dbget-bin/www_bget?ko:K07377 A1XQX0 1713 1.6e-189 Neurexin-1a OS=Danio rerio GN=nrxn1a PE=2 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.41410 BP_3 402.55 8.37 2611 642913707 XP_008201129.1 453 5.0e-42 PREDICTED: trans-Golgi network integral membrane protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41411 BP_3 138.25 7.82 1144 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41412 BP_3 1921.65 40.09 2602 642913707 XP_008201129.1 457 1.7e-42 PREDICTED: trans-Golgi network integral membrane protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02116 Fungal pheromone mating factor STE2 GPCR GO:0007186//GO:0019236//GO:0007606 G-protein coupled receptor signaling pathway//response to pheromone//sensory perception of chemical stimulus GO:0004932 mating-type factor pheromone receptor activity GO:0016020 membrane -- -- Cluster-8309.41413 BP_3 157.12 9.07 1127 642913445 XP_008201015.1 214 1.1e-14 PREDICTED: trypsin-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21902 148 2.1e-08 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41414 BP_3 68.59 2.76 1488 576636739 AHH30812.1 150 3.9e-07 fatty acid desaturase D5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41415 BP_3 96.04 4.20 1393 189239759 XP_001807559.1 537 4.9e-52 PREDICTED: transcription factor MafK [Tribolium castaneum]>gi|270012669|gb|EFA09117.1| hypothetical protein TcasGA2_TC015977 [Tribolium castaneum] -- -- -- -- -- K09037 MAFF_G_K transcription factor MAFF/G/K http://www.genome.jp/dbget-bin/www_bget?ko:K09037 O60675 284 4.4e-24 Transcription factor MafK OS=Homo sapiens GN=MAFK PE=1 SV=1 PF04111//PF03131//PF00170//PF07716//PF03404 Autophagy protein Apg6//bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper//Mo-co oxidoreductase dimerisation domain GO:0006914//GO:0055114//GO:0006355 autophagy//oxidation-reduction process//regulation of transcription, DNA-templated GO:0030151//GO:0016491//GO:0003677//GO:0003700//GO:0043565 molybdenum ion binding//oxidoreductase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.41416 BP_3 83.96 3.75 1372 189239759 XP_001807559.1 537 4.8e-52 PREDICTED: transcription factor MafK [Tribolium castaneum]>gi|270012669|gb|EFA09117.1| hypothetical protein TcasGA2_TC015977 [Tribolium castaneum] -- -- -- -- -- K09037 MAFF_G_K transcription factor MAFF/G/K http://www.genome.jp/dbget-bin/www_bget?ko:K09037 O60675 284 4.3e-24 Transcription factor MafK OS=Homo sapiens GN=MAFK PE=1 SV=1 PF03404//PF07716//PF00170//PF03131//PF04111 Mo-co oxidoreductase dimerisation domain//Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor//Autophagy protein Apg6 GO:0055114//GO:0006355//GO:0006914 oxidation-reduction process//regulation of transcription, DNA-templated//autophagy GO:0003700//GO:0043565//GO:0030151//GO:0016491//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//molybdenum ion binding//oxidoreductase activity//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.41417 BP_3 258.52 2.87 4630 270011694 EFA08142.1 1526 3.4e-166 hypothetical protein TcasGA2_TC005759 [Tribolium castaneum] 170045052 XM_001850085.1 49 1.21427e-13 Culex quinquefasciatus heparan sulfate glucosamine 3-O-sulfotransferase 3B1, mRNA K07809 HS3ST3 http://www.genome.jp/dbget-bin/www_bget?ko:K07809 Q9QZS6 961 4.6e-102 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 OS=Mus musculus GN=Hs3st3b1 PE=2 SV=2 PF00685//PF00160 Sulfotransferase domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755//GO:0008146 peptidyl-prolyl cis-trans isomerase activity//sulfotransferase activity -- -- KOG3704 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase Cluster-8309.41419 BP_3 25.51 7.56 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41420 BP_3 140.14 7.73 1165 189235871 XP_001811450.1 829 5.6e-86 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41423 BP_3 317.19 3.82 4298 642915716 XP_008190773.1 2335 4.9e-260 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X4 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.4e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF01920//PF00621 Prefoldin subunit//RhoGEF domain GO:0043087//GO:0035023//GO:0006457 regulation of GTPase activity//regulation of Rho protein signal transduction//protein folding GO:0005089//GO:0051082 Rho guanyl-nucleotide exchange factor activity//unfolded protein binding GO:0016272 prefoldin complex KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.41424 BP_3 69.06 8.46 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41426 BP_3 2009.92 24.29 4280 91078690 XP_971137.1 2336 3.7e-260 PREDICTED: eukaryotic translation initiation factor 3 subunit L [Tribolium castaneum]>gi|270003761|gb|EFA00209.1| hypothetical protein TcasGA2_TC003034 [Tribolium castaneum] -- -- -- -- -- K15029 EIF3L translation initiation factor 3 subunit L http://www.genome.jp/dbget-bin/www_bget?ko:K15029 Q16FL6 1819 1.4e-201 Eukaryotic translation initiation factor 3 subunit L OS=Aedes aegypti GN=AAEL009617 PE=3 SV=1 PF10255//PF07668 RNA polymerase I-associated factor PAF67//M penetrans paralogue family 1 GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0016020//GO:0005840//GO:0005737//GO:0005852 membrane//ribosome//cytoplasm//eukaryotic translation initiation factor 3 complex KOG4197 FOG: PPR repeat Cluster-8309.41427 BP_3 607.77 5.53 5587 642927663 XP_008195354.1 1331 1.7e-143 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 A0JNC2 395 2.4e-36 R3H domain-containing protein 2 OS=Bos taurus GN=R3HDM2 PE=2 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.41428 BP_3 435.32 5.98 3803 642928866 XP_008195596.1 3152 0.0e+00 PREDICTED: protein EFR3 homolog cmp44E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IGJ0 2001 9.5e-223 Protein EFR3 homolog cmp44E OS=Drosophila melanogaster GN=stmA PE=2 SV=3 PF07244//PF05000 Surface antigen variable number repeat//RNA polymerase Rpb1, domain 4 GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0019867//GO:0005730 outer membrane//nucleolus KOG1877 Putative transmembrane protein cmp44E Cluster-8309.41429 BP_3 24878.74 3120.39 676 478249910 ENN70417.1 396 5.3e-36 hypothetical protein YQE_12922, partial [Dendroctonus ponderosae]>gi|546677538|gb|ERL88357.1| hypothetical protein D910_05744 [Dendroctonus ponderosae] 195578330 XM_002078983.1 75 5.97877e-29 Drosophila simulans GD23732 (Dsim\GD23732), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41430 BP_3 199.05 3.42 3097 478249910 ENN70417.1 396 2.4e-35 hypothetical protein YQE_12922, partial [Dendroctonus ponderosae]>gi|546677538|gb|ERL88357.1| hypothetical protein D910_05744 [Dendroctonus ponderosae] 195578330 XM_002078983.1 75 2.84884e-28 Drosophila simulans GD23732 (Dsim\GD23732), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41434 BP_3 7.00 0.69 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41435 BP_3 251.74 2.38 5397 407731620 AFU25696.1 4540 0.0e+00 Na+,K+ ATPase alpha-subunit 2, partial [Tetraopes tetrophthalmus] 407731619 JQ771527.1 1269 0 Tetraopes tetrophthalmus Na+,K+ ATPase alpha-subunit 2 mRNA, partial cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 2978 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF04565//PF00122 RNA polymerase Rpb2, domain 3//E1-E2 ATPase GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872//GO:0000166 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//nucleotide binding GO:0005730 nucleolus KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.41436 BP_3 3.00 4.04 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41438 BP_3 13.02 0.35 2096 189236651 XP_969621.2 670 2.8e-67 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 2 [Tribolium castaneum]>gi|270005204|gb|EFA01652.1| hypothetical protein TcasGA2_TC007223 [Tribolium castaneum] 642920726 XM_964528.3 122 1.43174e-54 PREDICTED: Tribolium castaneum polypeptide N-acetylgalactosaminyltransferase 2 (LOC658118), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV19 345 5.5e-31 Polypeptide N-acetylgalactosaminyltransferase 2 OS=Drosophila melanogaster GN=pgant2 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.41439 BP_3 891.19 9.42 4852 91084129 XP_969781.1 4741 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 76 1.24622e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA -- -- -- -- Q54U44 1645 2.3e-181 ABC transporter C family member 12 OS=Dictyostelium discoideum GN=abcC12 PE=3 SV=1 PF01926//PF13304//PF00664//PF08477//PF06552//PF00931//PF01637//PF02456//PF03193//PF00005 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase//Plant specific mitochondrial import receptor subunit TOM20//NB-ARC domain//Archaeal ATPase//Adenovirus IVa2 protein//Protein of unknown function, DUF258//ABC transporter GO:0007264//GO:0045040//GO:0006200//GO:0006810//GO:0055085//GO:0019083 small GTPase mediated signal transduction//protein import into mitochondrial outer membrane//obsolete ATP catabolic process//transport//transmembrane transport//viral transcription GO:0042626//GO:0016887//GO:0005525//GO:0003924//GO:0043531//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//GTPase activity//ADP binding//ATP binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane -- -- Cluster-8309.41440 BP_3 416.26 4.34 4915 91084129 XP_969781.1 2413 5.0e-269 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 76 1.26252e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1310 1.6e-142 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF06552//PF03193//PF00005//PF02456//PF01637//PF01926//PF13304//PF00664 Plant specific mitochondrial import receptor subunit TOM20//Protein of unknown function, DUF258//ABC transporter//Adenovirus IVa2 protein//Archaeal ATPase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0009987//GO:0045040//GO:0006810//GO:0019083//GO:0055085 cellular process//protein import into mitochondrial outer membrane//transport//viral transcription//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0000166//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//nucleotide binding//GTPase activity//ATP binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane -- -- Cluster-8309.41442 BP_3 9.73 1.62 581 646712993 KDR17513.1 144 7.6e-07 putative cytochrome c oxidase polypeptide 7A1, mitochondrial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41443 BP_3 133.59 5.96 1372 642935257 XP_008197935.1 1283 1.5e-138 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 330 2.0e-29 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.41445 BP_3 17.00 0.82 1290 642911623 XP_008200676.1 1313 4.7e-142 PREDICTED: trypsin I-P1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21902 519 2.3e-51 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41447 BP_3 674.43 26.79 1505 642916373 XP_008190993.1 861 1.4e-89 PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum]>gi|642916375|ref|XP_008190995.1| PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q7Z429 451 2.0e-43 Protein lifeguard 1 OS=Homo sapiens GN=GRINA PE=2 SV=1 PF00335//PF00032 Tetraspanin family//Cytochrome b(C-terminal)/b6/petD GO:0006118 obsolete electron transport GO:0016491//GO:0009055 oxidoreductase activity//electron carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.41449 BP_3 4019.54 49.72 4188 642921291 XP_008192803.1 4509 0.0e+00 PREDICTED: disheveled-associated activator of morphogenesis 1 isoform X3 [Tribolium castaneum]>gi|270005074|gb|EFA01522.1| hypothetical protein TcasGA2_TC007082 [Tribolium castaneum] 642921290 XM_008194581.1 501 0 PREDICTED: Tribolium castaneum disheveled-associated activator of morphogenesis 1 (LOC658864), transcript variant X3, mRNA K04512 DAAM dishevelled associated activator of morphogenesis http://www.genome.jp/dbget-bin/www_bget?ko:K04512 Q8BPM0 1369 2.0e-149 Disheveled-associated activator of morphogenesis 1 OS=Mus musculus GN=Daam1 PE=1 SV=4 PF04561//PF01763//PF06367//PF06371 RNA polymerase Rpb2, domain 2//Herpesvirus UL6 like//Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0006351//GO:0016043//GO:0006144//GO:0006206//GO:0030036//GO:0006323 transcription, DNA-templated//cellular component organization//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//actin cytoskeleton organization//DNA packaging GO:0003677//GO:0003899//GO:0003779//GO:0017048 DNA binding//DNA-directed RNA polymerase activity//actin binding//Rho GTPase binding GO:0005730 nucleolus KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.41451 BP_3 350.00 18.29 1214 91081381 XP_972215.1 907 5.3e-95 PREDICTED: ribose-5-phosphate isomerase [Tribolium castaneum]>gi|270005180|gb|EFA01628.1| hypothetical protein TcasGA2_TC007198 [Tribolium castaneum] -- -- -- -- -- K01807 rpiA ribose 5-phosphate isomerase A http://www.genome.jp/dbget-bin/www_bget?ko:K01807 P49247 790 8.0e-83 Ribose-5-phosphate isomerase OS=Homo sapiens GN=RPIA PE=1 SV=3 PF06026//PF04152 Ribose 5-phosphate isomerase A (phosphoriboisomerase A)//Mre11 DNA-binding presumed domain GO:0006098//GO:0006302//GO:0015976//GO:0009052 pentose-phosphate shunt//double-strand break repair//carbon utilization//pentose-phosphate shunt, non-oxidative branch GO:0004751//GO:0030145//GO:0004519 ribose-5-phosphate isomerase activity//manganese ion binding//endonuclease activity GO:0005634 nucleus KOG3075 Ribose 5-phosphate isomerase Cluster-8309.41452 BP_3 100.40 1.47 3581 91077414 XP_975386.1 1918 9.2e-212 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 4.6e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF12634//PF00516//PF06723//PF02782//PF13414//PF15281 Inheritance of peroxisomes protein 1//Envelope glycoprotein GP120//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//TPR repeat//Consortin C-terminus GO:0005975//GO:0045033//GO:0000902//GO:0042998//GO:0006457 carbohydrate metabolic process//peroxisome inheritance//cell morphogenesis//positive regulation of Golgi to plasma membrane protein transport//protein folding GO:0016773//GO:0051082//GO:0005515//GO:0071253//GO:0005524 phosphotransferase activity, alcohol group as acceptor//unfolded protein binding//protein binding//connexin binding//ATP binding GO:0005802//GO:0019031//GO:0005780 trans-Golgi network//viral envelope//extrinsic component of intraperoxisomal membrane KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.41453 BP_3 976.00 12.83 3957 642938608 XP_008199863.1 2835 0.0e+00 PREDICTED: semaphorin-5A [Tribolium castaneum] -- -- -- -- -- K06841 SEMA5 semaphorin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06841 Q60519 1711 4.2e-189 Semaphorin-5B OS=Mus musculus GN=Sema5b PE=2 SV=2 PF04850//PF01403 Baculovirus E66 occlusion-derived virus envelope protein//Sema domain -- -- GO:0005515 protein binding GO:0019031 viral envelope -- -- Cluster-8309.41454 BP_3 1093.93 16.60 3468 642929255 XP_008195756.1 2075 5.5e-230 PREDICTED: PX domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270009666|gb|EFA06114.1| hypothetical protein TcasGA2_TC008957 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q7Z7A4 1138 1.0e-122 PX domain-containing protein kinase-like protein OS=Homo sapiens GN=PXK PE=1 SV=1 PF02285//PF02205//PF07714//PF02569//PF00787//PF00069 Cytochrome oxidase c subunit VIII//WH2 motif//Protein tyrosine kinase//Pantoate-beta-alanine ligase//PX domain//Protein kinase domain GO:0019482//GO:0015992//GO:0007154//GO:0006123//GO:0015940//GO:0006468 beta-alanine metabolic process//proton transport//cell communication//mitochondrial electron transport, cytochrome c to oxygen//pantothenate biosynthetic process//protein phosphorylation GO:0004592//GO:0004129//GO:0004672//GO:0005524//GO:0003779//GO:0035091 pantoate-beta-alanine ligase activity//cytochrome-c oxidase activity//protein kinase activity//ATP binding//actin binding//phosphatidylinositol binding GO:0045277 respiratory chain complex IV KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.41456 BP_3 4937.79 51.23 4937 189237669 XP_967427.2 2476 2.5e-276 PREDICTED: hypoxia-inducible factor 1-alpha [Tribolium castaneum] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 Q24167 843 2.3e-88 Protein similar OS=Drosophila melanogaster GN=sima PE=1 SV=2 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3558 Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1 Cluster-8309.41457 BP_3 122.96 1.30 4862 -- -- -- -- -- 86515329 NM_001039401.1 63 2.10453e-21 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.41458 BP_3 2303.85 23.46 5026 546673034 ERL84720.1 3183 0.0e+00 hypothetical protein D910_02145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24247 1695 3.8e-187 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 PF06529 Vertebrate interleukin-3 regulated transcription factor GO:0007623//GO:0006351 circadian rhythm//transcription, DNA-templated -- -- GO:0005634 nucleus KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.41459 BP_3 37.52 1.40 1587 91086225 XP_972341.1 1458 8.9e-159 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 820970777 XM_004634227.2 194 1.01882e-94 PREDICTED: Octodon degus STT3B, subunit of the oligosaccharyltransferase complex (catalytic) (Stt3b), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 1163 5.9e-126 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016020 oligosaccharyltransferase complex//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.41460 BP_3 41.16 0.54 3989 755930004 XP_011312621.1 2447 4.7e-273 PREDICTED: multidrug resistance-associated protein 4-like [Fopius arisanus] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1117 3.2e-120 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00005//PF03193//PF00664//PF13304//PF01926 ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.41462 BP_3 7.00 0.47 1011 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41463 BP_3 136.71 1.36 5132 91080629 XP_974349.1 945 8.8e-99 PREDICTED: tetraspanin-9 [Tribolium castaneum]>gi|270005823|gb|EFA02271.1| hypothetical protein TcasGA2_TC007935 [Tribolium castaneum] 5628 X01518.1 48 4.84452e-13 Acyrthosiphon magnoliae (aphid) 5S ribosomal RNA K17350 TSPAN9 tetraspanin-9 http://www.genome.jp/dbget-bin/www_bget?ko:K17350 B0BM39 415 1.0e-38 Tetraspanin-9 OS=Xenopus tropicalis GN=tspan9 PE=2 SV=1 PF00335//PF06687//PF02949 Tetraspanin family//SUR7/PalI family//7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane -- -- Cluster-8309.41465 BP_3 580.64 5.23 5642 642914563 XP_008201731.1 4144 0.0e+00 PREDICTED: histone-lysine N-methyltransferase ash1 isoform X2 [Tribolium castaneum]>gi|270001477|gb|EEZ97924.1| hypothetical protein TcasGA2_TC000311 [Tribolium castaneum] -- -- -- -- -- K06101 ASH1L histone-lysine N-methyltransferase ASH1L http://www.genome.jp/dbget-bin/www_bget?ko:K06101 Q9VW15 1058 3.1e-113 Histone-lysine N-methyltransferase ash1 OS=Drosophila melanogaster GN=ash1 PE=1 SV=3 PF00439//PF00856//PF01426//PF02378//PF00628 Bromodomain//SET domain//BAH domain//Phosphotransferase system, EIIC//PHD-finger GO:0009401//GO:0008643 phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport GO:0008982//GO:0005488//GO:0003682//GO:0016740//GO:0005515 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//binding//chromatin binding//transferase activity//protein binding GO:0009357//GO:0016020//GO:0000785 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane//chromatin KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.41467 BP_3 18.03 0.71 1510 478254782 ENN75018.1 768 8.7e-79 hypothetical protein YQE_08333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BTX7 163 5.1e-10 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41468 BP_3 3.00 18.37 257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41469 BP_3 9502.34 54.89 8635 270297218 NP_001161918.1 773 1.3e-78 cuticular protein analogous to peritrophins 1-H precursor [Tribolium castaneum]>gi|642929138|ref|XP_008195708.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|642929140|ref|XP_008195709.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|268309014|gb|ACY95473.1| cuticular protein analogous to peritrophins 1-H [Tribolium castaneum]>gi|270010495|gb|EFA06943.1| hypothetical protein TcasGA2_TC009894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07827//PF01607 KNTase C-terminal domain//Chitin binding Peritrophin-A domain GO:0006030//GO:0046677 chitin metabolic process//response to antibiotic GO:0016779//GO:0008061 nucleotidyltransferase activity//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.41473 BP_3 248.17 2.20 5732 642929442 XP_008195842.1 5299 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X3 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 4034 0.0e+00 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF00312//PF00520//PF16519 Ribosomal protein S15//Ion transport protein//Tetramerisation domain of TRPM GO:0006811//GO:0042254//GO:0055085//GO:0051262//GO:0006412 ion transport//ribosome biogenesis//transmembrane transport//protein tetramerization//translation GO:0005216//GO:0003735 ion channel activity//structural constituent of ribosome GO:0005622//GO:0016020//GO:0005840 intracellular//membrane//ribosome KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.41474 BP_3 224.13 1.19 9379 642926040 XP_008194740.1 10464 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 1035 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 7579 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF02655//PF02786//PF07478//PF08326 ATP-grasp domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus//Acetyl-CoA carboxylase, central region GO:0046436//GO:0006633//GO:0009252//GO:0006090 D-alanine metabolic process//fatty acid biosynthetic process//peptidoglycan biosynthetic process//pyruvate metabolic process GO:0005524//GO:0003989//GO:0008716//GO:0046872 ATP binding//acetyl-CoA carboxylase activity//D-alanine-D-alanine ligase activity//metal ion binding GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.41475 BP_3 281.14 2.29 6203 642926044 XP_008194742.1 8497 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X3 [Tribolium castaneum] 827556928 XM_012694321.1 547 0 PREDICTED: Bombyx mori acetyl-CoA carboxylase (LOC101738903), transcript variant X3, mRNA K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 6090 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF08326 Acetyl-CoA carboxylase, central region GO:0006633//GO:0006090 fatty acid biosynthetic process//pyruvate metabolic process GO:0003989//GO:0005524 acetyl-CoA carboxylase activity//ATP binding GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.41476 BP_3 669.14 11.79 3028 642919702 XP_008192028.1 2244 1.2e-249 PREDICTED: inositol-trisphosphate 3-kinase A-like [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 900 3.5e-95 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.41478 BP_3 1354.62 26.32 2772 478250432 ENN70927.1 576 2.9e-56 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] 645036882 XM_001607897.2 186 5.0276e-90 PREDICTED: Nasonia vitripennis histone H2A-like (LOC100114644), mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P84054 471 1.8e-45 Histone H2A OS=Drosophila simulans GN=His2A PE=3 SV=2 PF12513//PF00125//PF00656 Mitochondrial degradasome RNA helicase subunit C terminal//Core histone H2A/H2B/H3/H4//Caspase domain GO:0006508 proteolysis GO:0004197//GO:0016817//GO:0003677 cysteine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//DNA binding -- -- -- -- Cluster-8309.41479 BP_3 1779.00 31.71 2996 642930314 XP_008196343.1 1168 7.1e-125 PREDICTED: UDP-glucuronosyltransferase 2B17-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02663 447 1.2e-42 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.41481 BP_3 482.80 4.54 5412 270011060 EFA07508.1 3836 0.0e+00 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20742 1227 7.6e-133 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 PF07678//PF07677//PF01835//PF01483//PF00207 A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain//Proprotein convertase P-domain//Alpha-2-macroglobulin family GO:0006508 proteolysis GO:0004866//GO:0004252 endopeptidase inhibitor activity//serine-type endopeptidase activity GO:0005576//GO:0005615 extracellular region//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.41482 BP_3 487.92 8.68 3000 478257576 ENN77730.1 2406 2.0e-268 hypothetical protein YQE_05801, partial [Dendroctonus ponderosae] -- -- -- -- -- K12261 HACL1 2-hydroxyacyl-CoA lyase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12261 Q9UJ83 1577 1.1e-173 2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens GN=HACL1 PE=1 SV=2 PF00205//PF02775//PF02776//PF02552 Thiamine pyrophosphate enzyme, central domain//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit GO:0019385 methanogenesis, from acetate GO:0000287//GO:0030976//GO:0003824 magnesium ion binding//thiamine pyrophosphate binding//catalytic activity -- -- KOG1185 Thiamine pyrophosphate-requiring enzyme Cluster-8309.41484 BP_3 747.00 26.41 1655 642922490 XP_008193193.1 963 2.3e-101 PREDICTED: protein big brother-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24040 770 2.3e-80 Protein big brother OS=Drosophila melanogaster GN=Bgb PE=2 SV=3 PF02312 Core binding factor beta subunit -- -- GO:0003713 transcription coactivator activity GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.41485 BP_3 32.95 0.64 2779 546685202 ERL94729.1 1287 1.0e-138 hypothetical protein D910_12003 [Dendroctonus ponderosae] -- -- -- -- -- K08860 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08860 Q9NIV1 568 1.0e-56 Eukaryotic translation initiation factor 2-alpha kinase OS=Drosophila melanogaster GN=PEK PE=1 SV=2 PF06293//PF00069//PF07714//PF10588 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114//GO:0006468 oxidation-reduction process//protein phosphorylation GO:0016491//GO:0004672//GO:0005524//GO:0016773 oxidoreductase activity//protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1035 eIF-2alpha kinase GCN2 Cluster-8309.41486 BP_3 982.44 13.79 3726 642931768 XP_008196720.1 1923 2.5e-212 PREDICTED: cytohesin-1 isoform X3 [Tribolium castaneum] 676429235 XM_009047286.1 185 2.43875e-89 Lottia gigantea hypothetical protein partial mRNA K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q15438 1356 5.8e-148 Cytohesin-1 OS=Homo sapiens GN=CYTH1 PE=1 SV=1 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.41487 BP_3 27.06 0.38 3701 642931770 XP_008196721.1 1314 1.0e-141 PREDICTED: cytohesin-1 isoform X4 [Tribolium castaneum] 749754538 XM_011141408.1 144 1.49965e-66 PREDICTED: Harpegnathos saltator cytohesin-1-like (LOC105183356), transcript variant X2, mRNA K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q15438 980 2.3e-104 Cytohesin-1 OS=Homo sapiens GN=CYTH1 PE=1 SV=1 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.41488 BP_3 344.93 5.21 3484 665810054 XP_008553427.1 1656 2.1e-181 PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|665810056|ref|XP_008553428.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|751201535|ref|XP_011167836.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Solenopsis invicta]>gi|780681748|ref|XP_011697692.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Wasmannia auropunctata]>gi|795064613|ref|XP_011874023.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Vollenhovia emeryi]>gi|826425920|ref|XP_012527326.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Monomorium pharaonis] 642933469 XM_968453.3 436 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (LOC662352), mRNA K04382 PPP2C serine/threonine-protein phosphatase 2A catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04382 P62716 1626 2.7e-179 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2cb PE=2 SV=1 PF09494//PF02135//PF01086//PF00149 Slx4 endonuclease//TAZ zinc finger//Clathrin light chain//Calcineurin-like phosphoesterase GO:0016192//GO:0042967//GO:0006281//GO:0006886//GO:0006355//GO:0006260//GO:0006308 vesicle-mediated transport//acyl-carrier-protein biosynthetic process//DNA repair//intracellular protein transport//regulation of transcription, DNA-templated//DNA replication//DNA catabolic process GO:0017108//GO:0005198//GO:0016787//GO:0008270//GO:0003712//GO:0004402 5'-flap endonuclease activity//structural molecule activity//hydrolase activity//zinc ion binding//transcription cofactor activity//histone acetyltransferase activity GO:0030132//GO:0030130//GO:0005667//GO:0005634//GO:0033557//GO:0000123 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle//transcription factor complex//nucleus//Slx1-Slx4 complex//histone acetyltransferase complex KOG0371 Serine/threonine protein phosphatase 2A, catalytic subunit Cluster-8309.41489 BP_3 476.45 7.10 3527 91090364 XP_968231.1 1218 1.3e-130 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5U6 509 9.0e-50 RING finger protein 10 OS=Homo sapiens GN=RNF10 PE=1 SV=2 PF11789//PF13639//PF02891//PF14634//PF00097 Zinc-finger of the MIZ type in Nse subunit//Ring finger domain//MIZ/SP-RING zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG2164 Predicted E3 ubiquitin ligase Cluster-8309.41490 BP_3 1916.24 7.01 13468 270007741 EFA04189.1 1783 1.6e-195 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 221 8.62628e-109 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q96EP0 868 8.1e-91 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens GN=RNF31 PE=1 SV=1 PF01426//PF13465//PF07975//PF00412//PF00641//PF09182//PF13912//PF02845//PF08273//PF00096//PF05495//PF07776 BAH domain//Zinc-finger double domain//TFIIH C1-like domain//LIM domain//Zn-finger in Ran binding protein and others//Bacterial purine repressor, N-terminal//C2H2-type zinc finger//CUE domain//Zinc-binding domain of primase-helicase//Zinc finger, C2H2 type//CHY zinc finger//Zinc-finger associated domain (zf-AD) GO:0006355//GO:0006269//GO:0006351//GO:0006281 regulation of transcription, DNA-templated//DNA replication, synthesis of RNA primer//transcription, DNA-templated//DNA repair GO:0008270//GO:0003682//GO:0046872//GO:0004386//GO:0003896//GO:0003677//GO:0005515 zinc ion binding//chromatin binding//metal ion binding//helicase activity//DNA primase activity//DNA binding//protein binding GO:0005730//GO:0000785//GO:0005657//GO:0005634 nucleolus//chromatin//replication fork//nucleus -- -- Cluster-8309.41491 BP_3 86.22 0.92 4791 746838316 XP_011049678.1 1675 1.8e-183 PREDICTED: uncharacterized protein LOC105143221 isoform X1 [Acromyrmex echinatior]>gi|332028468|gb|EGI68511.1| Monocarboxylate transporter 14 [Acromyrmex echinatior] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 447 1.9e-42 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF07690//PF02472//PF12537 Sugar (and other) transporter//Major Facilitator Superfamily//Biopolymer transport protein ExbD/TolR//The Golgi pH Regulator (GPHR) Family N-terminal GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.41495 BP_3 30.03 0.34 4532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41497 BP_3 566.59 3.34 8459 642915855 XP_008196222.1 3032 0.0e+00 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X2 [Tribolium castaneum] 642915388 XM_008192374.1 178 4.3321e-85 PREDICTED: Tribolium castaneum uncharacterized LOC100141615 (LOC100141615), transcript variant X2, mRNA K16343 PLA2G6, IPLA2 calcium-independent phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K16343 O60733 1322 1.1e-143 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens GN=PLA2G6 PE=1 SV=2 PF01734//PF13606//PF00023 Patatin-like phospholipase//Ankyrin repeat//Ankyrin repeat GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.41498 BP_3 820.68 4.76 8603 642915855 XP_008196222.1 3032 0.0e+00 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X2 [Tribolium castaneum] 642915388 XM_008192374.1 179 1.22508e-85 PREDICTED: Tribolium castaneum uncharacterized LOC100141615 (LOC100141615), transcript variant X2, mRNA K16343 PLA2G6, IPLA2 calcium-independent phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K16343 O60733 1322 1.2e-143 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens GN=PLA2G6 PE=1 SV=2 PF13606//PF01734//PF00023//PF00320 Ankyrin repeat//Patatin-like phospholipase//Ankyrin repeat//GATA zinc finger GO:0006355//GO:0006629 regulation of transcription, DNA-templated//lipid metabolic process GO:0043565//GO:0008270//GO:0005515//GO:0003700 sequence-specific DNA binding//zinc ion binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.415 BP_3 6.00 0.57 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41500 BP_3 68.72 0.40 8491 642915855 XP_008196222.1 3032 0.0e+00 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X2 [Tribolium castaneum] 642915388 XM_008192374.1 178 4.34856e-85 PREDICTED: Tribolium castaneum uncharacterized LOC100141615 (LOC100141615), transcript variant X2, mRNA K16343 PLA2G6, IPLA2 calcium-independent phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K16343 O60733 1322 1.2e-143 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens GN=PLA2G6 PE=1 SV=2 PF00023//PF01734//PF13606 Ankyrin repeat//Patatin-like phospholipase//Ankyrin repeat GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.41502 BP_3 1439.33 31.62 2486 147902182 NP_001079763.1 447 2.4e-41 ER lumen protein-retaining receptor 3 [Xenopus laevis]>gi|6685399|sp|O42580.1|ERD23_XENLA RecName: Full=ER lumen protein-retaining receptor 3; AltName: Full=KDEL endoplasmic reticulum protein retention receptor 3; Short=KDEL receptor 3 [Xenopus laevis]>gi|2467290|emb|CAA04817.1| KDEL receptor [Xenopus laevis]>gi|32450093|gb|AAH54181.1| MGC64313 protein [Xenopus laevis] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 Q66JF2 456 8.8e-44 ER lumen protein-retaining receptor 3 OS=Xenopus tropicalis GN=kdelr3 PE=2 SV=1 PF00810//PF15050//PF05297 ER lumen protein retaining receptor//SCIMP protein//Herpesvirus latent membrane protein 1 (LMP1) GO:0019087//GO:0006621 transformation of host cell by virus//protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0097197//GO:0005783//GO:0001772//GO:0016021 tetraspanin-enriched microdomain//endoplasmic reticulum//immunological synapse//integral component of membrane KOG3106 ER lumen protein retaining receptor Cluster-8309.41503 BP_3 345.85 0.98 17236 642913486 XP_008201031.1 6078 0.0e+00 PREDICTED: histone-lysine N-methyltransferase 2C-like isoform X2 [Tribolium castaneum] 662203306 XM_008476764.1 101 5.63234e-42 PREDICTED: Diaphorina citri histone-lysine N-methyltransferase trr-like (LOC103512007), mRNA K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8IRW8 1336 5.6e-145 Histone-lysine N-methyltransferase trr OS=Drosophila melanogaster GN=trr PE=1 SV=2 PF05964//PF00628//PF07155//PF05965//PF00856 F/Y-rich N-terminus//PHD-finger//ECF-type riboflavin transporter, S component//F/Y rich C-terminus//SET domain -- -- GO:0005515 protein binding GO:0005634//GO:0016020 nucleus//membrane KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8309.41504 BP_3 540.15 4.23 6450 270014159 EFA10607.1 893 1.2e-92 hypothetical protein TcasGA2_TC012868 [Tribolium castaneum] 642936629 XM_008200293.1 231 1.13712e-114 PREDICTED: Tribolium castaneum serine-arginine protein 55-like (LOC660636), mRNA K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 732 2.3e-75 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00102//PF08777//PF04179//PF16367//PF00076//PF01416//PF00782//PF01529//PF02868 Protein-tyrosine phosphatase//RNA binding motif//Initiator tRNA phosphoribosyl transferase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA pseudouridine synthase//Dual specificity phosphatase, catalytic domain//DHHC palmitoyltransferase//Thermolysin metallopeptidase, alpha-helical domain GO:0019988//GO:0006570//GO:0006470//GO:0009451//GO:0001522 charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation//RNA modification//pseudouridine synthesis GO:0004222//GO:0003723//GO:0043399//GO:0008138//GO:0004725//GO:0008270//GO:0003676//GO:0009982 metalloendopeptidase activity//RNA binding//tRNA A64-2'-O-ribosylphosphate transferase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//zinc ion binding//nucleic acid binding//pseudouridine synthase activity -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.41505 BP_3 97.94 1.87 2812 270007934 EFA04382.1 2290 5.3e-255 hypothetical protein TcasGA2_TC014680 [Tribolium castaneum] 689427973 LL903388.1 36 1.23653e-06 Schistocephalus solidus genome assembly S_solidus_NST_G2 ,scaffold SSLN_scaffold0003160 K07515 HADHA enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07515 Q29554 1616 3.1e-178 Trifunctional enzyme subunit alpha, mitochondrial OS=Sus scrofa GN=HADHA PE=1 SV=1 PF03446//PF01048//PF16113//PF00378//PF02737//PF02529//PF02609//PF00725 NAD binding domain of 6-phosphogluconate dehydrogenase//Phosphorylase superfamily//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Cytochrome B6-F complex subunit 5//Exonuclease VII small subunit//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GO:0055114//GO:0006554//GO:0019521//GO:0006568//GO:0009116//GO:0006550//GO:0006574//GO:0006308//GO:0006552//GO:0006631//GO:0006633//GO:0006098//GO:0018874//GO:0008152 oxidation-reduction process//lysine catabolic process//D-gluconate metabolic process//tryptophan metabolic process//nucleoside metabolic process//isoleucine catabolic process//valine catabolic process//DNA catabolic process//leucine catabolic process//fatty acid metabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//metabolic process GO:0004616//GO:0003857//GO:0008855//GO:0016491//GO:0003824//GO:0016836 phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//exodeoxyribonuclease VII activity//oxidoreductase activity//catalytic activity//hydro-lyase activity GO:0009318//GO:0009512 exodeoxyribonuclease VII complex//cytochrome b6f complex KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.41507 BP_3 78.28 0.62 6363 642935825 XP_008198191.1 5079 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum]>gi|642935827|ref|XP_008198192.1| PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum]>gi|642935829|ref|XP_008198193.1| PREDICTED: rho guanine nucleotide exchange factor 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1084 3.4e-116 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621//PF11770//PF03357 RhoGEF domain//GRB2-binding adapter (GAPT)//Snf7 GO:0007034//GO:0043087//GO:0035023 vacuolar transport//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0016021 integral component of membrane KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.41508 BP_3 474.00 5.21 4676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41510 BP_3 917.75 14.48 3347 642918336 XP_008196857.1 2258 3.2e-251 PREDICTED: serine/threonine-protein kinase tricorner [Tribolium castaneum] 752860508 XM_011253959.1 362 0 PREDICTED: Camponotus floridanus serine/threonine-protein kinase tricorner (LOC105248897), transcript variant X2, mRNA K08790 STK38, NDR serine/threonine kinase 38 http://www.genome.jp/dbget-bin/www_bget?ko:K08790 Q2LZZ7 2013 3.4e-224 Serine/threonine-protein kinase tricorner OS=Drosophila pseudoobscura pseudoobscura GN=trc PE=3 SV=1 PF00069//PF06293//PF00433//PF07714//PF04998 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//Protein tyrosine kinase//RNA polymerase Rpb1, domain 5 GO:0006351//GO:0016310//GO:0006468//GO:0006144//GO:0009069//GO:0006206 transcription, DNA-templated//phosphorylation//protein phosphorylation//purine nucleobase metabolic process//serine family amino acid metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005524//GO:0016773//GO:0004674//GO:0004672 DNA binding//DNA-directed RNA polymerase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity GO:0016020//GO:0005730 membrane//nucleolus KOG0605 NDR and related serine/threonine kinases Cluster-8309.41512 BP_3 423.25 9.17 2517 642936089 XP_008198299.1 3648 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 2 [Tribolium castaneum]>gi|270013200|gb|EFA09648.1| hypothetical protein TcasGA2_TC011774 [Tribolium castaneum] 752890085 XM_011264720.1 314 3.19429e-161 PREDICTED: Camponotus floridanus transcription initiation factor TFIID subunit 2 (LOC105255436), mRNA K03128 TAF2 transcription initiation factor TFIID subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03128 Q24325 2774 1.6e-312 Transcription initiation factor TFIID subunit 2 OS=Drosophila melanogaster GN=Taf2 PE=1 SV=2 PF01433 Peptidase family M1 GO:0032259 methylation GO:0003676//GO:0008237//GO:0008270//GO:0008168//GO:0004222 nucleic acid binding//metallopeptidase activity//zinc ion binding//methyltransferase activity//metalloendopeptidase activity -- -- KOG1932 TATA binding protein associated factor Cluster-8309.41513 BP_3 235.77 7.89 1732 642936089 XP_008198299.1 1494 6.5e-163 PREDICTED: transcription initiation factor TFIID subunit 2 [Tribolium castaneum]>gi|270013200|gb|EFA09648.1| hypothetical protein TcasGA2_TC011774 [Tribolium castaneum] -- -- -- -- -- K03128 TAF2 transcription initiation factor TFIID subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03128 Q24325 921 7.4e-98 Transcription initiation factor TFIID subunit 2 OS=Drosophila melanogaster GN=Taf2 PE=1 SV=2 PF02985 HEAT repeat GO:0032259 methylation GO:0003676//GO:0008168//GO:0004222//GO:0008270//GO:0005515 nucleic acid binding//methyltransferase activity//metalloendopeptidase activity//zinc ion binding//protein binding -- -- KOG1932 TATA binding protein associated factor Cluster-8309.41516 BP_3 2376.09 17.04 7014 546685725 ERL95180.1 4209 0.0e+00 hypothetical protein D910_12448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.5e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.41517 BP_3 595.27 12.49 2588 91081621 XP_966892.1 1552 1.8e-169 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O24145 893 2.0e-94 4-coumarate--CoA ligase 1 OS=Nicotiana tabacum GN=4CL1 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.41518 BP_3 64.73 0.53 6222 270013964 EFA10412.1 5274 0.0e+00 hypothetical protein TcasGA2_TC012652 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 4.3e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.41519 BP_3 329.94 12.22 1593 642927970 XP_972030.2 1040 2.6e-110 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] -- -- -- -- -- K14026 SEL1, SEL1L SEL1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14026 Q80Z70 530 1.5e-52 Protein sel-1 homolog 1 OS=Rattus norvegicus GN=Sel1l PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1550 Extracellular protein SEL-1 and related proteins Cluster-8309.41520 BP_3 323.43 16.20 1254 642927970 XP_972030.2 1037 4.6e-110 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] -- -- -- -- -- K14026 SEL1, SEL1L SEL1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14026 Q80Z70 530 1.2e-52 Protein sel-1 homolog 1 OS=Rattus norvegicus GN=Sel1l PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1550 Extracellular protein SEL-1 and related proteins Cluster-8309.41523 BP_3 249.20 1.99 6339 642917633 XP_008193409.1 5035 0.0e+00 PREDICTED: DNA topoisomerase 2 [Tribolium castaneum] 158299571 XM_319665.4 602 0 Anopheles gambiae str. PEST AGAP008917-PA (AgaP_AGAP008917) mRNA, partial cds K03164 TOP2 DNA topoisomerase II http://www.genome.jp/dbget-bin/www_bget?ko:K03164 O16140 4510 0.0e+00 DNA topoisomerase 2 OS=Bombyx mori GN=TOP2 PE=2 SV=1 PF01728//PF00204//PF00521 FtsJ-like methyltransferase//DNA gyrase B//DNA gyrase/topoisomerase IV, subunit A GO:0006265//GO:0032259 DNA topological change//methylation GO:0003677//GO:0005524//GO:0003918//GO:0008168 DNA binding//ATP binding//DNA topoisomerase type II (ATP-hydrolyzing) activity//methyltransferase activity -- -- KOG0355 DNA topoisomerase type II Cluster-8309.41526 BP_3 239.79 8.63 1631 642918353 XP_008199964.1 155 1.1e-07 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41527 BP_3 379.97 5.23 3792 332376073 AEE63177.1 2232 3.8e-248 unknown [Dendroctonus ponderosae] 751798911 XM_011211092.1 84 3.47102e-33 PREDICTED: Bactrocera dorsalis probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (LOC105230362), mRNA K00140 mmsA, iolA, ALDH6A1 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00140 Q17M80 1920 2.3e-213 Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Aedes aegypti GN=AAEL001134 PE=3 SV=1 PF00171//PF05893 Aldehyde dehydrogenase family//Acyl-CoA reductase (LuxC) GO:0008218//GO:0055114//GO:0006118//GO:0008152 bioluminescence//oxidation-reduction process//obsolete electron transport//metabolic process GO:0016491//GO:0003995 oxidoreductase activity//acyl-CoA dehydrogenase activity -- -- KOG2449 Methylmalonate semialdehyde dehydrogenase Cluster-8309.41530 BP_3 343.23 5.69 3201 270004099 EFA00547.1 889 1.7e-92 hypothetical protein TcasGA2_TC003413 [Tribolium castaneum] 442633737 NM_176374.2 162 1.27686e-76 Drosophila melanogaster knirps-like (knrl), mRNA K08706 NR0AN, kni nuclear receptor subfamily 0 group A http://www.genome.jp/dbget-bin/www_bget?ko:K08706 P13054 507 1.4e-49 Knirps-related protein OS=Drosophila melanogaster GN=knrl PE=2 SV=1 PF05337//PF00105//PF00645 Macrophage colony stimulating factor-1 (CSF-1)//Zinc finger, C4 type (two domains)//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0040007//GO:0007165//GO:0008283//GO:0006355 growth//signal transduction//cell proliferation//regulation of transcription, DNA-templated GO:0008083//GO:0003677//GO:0008270//GO:0043565//GO:0005125//GO:0003700 growth factor activity//DNA binding//zinc ion binding//sequence-specific DNA binding//cytokine activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005634//GO:0005667 integral component of membrane//nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.41531 BP_3 312.61 3.88 4171 642918310 XP_008191453.1 4172 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] -- -- -- -- -- K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 Q96PE3 739 2.3e-76 Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.41532 BP_3 2288.72 104.24 1350 642934210 XP_967287.2 215 1.0e-14 PREDICTED: uncharacterized protein C34C12.4 [Tribolium castaneum]>gi|270012965|gb|EFA09413.1| hypothetical protein TcasGA2_TC005215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91VT8 174 2.4e-11 Small integral membrane protein 14 OS=Mus musculus GN=Smim14 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41534 BP_3 792.42 7.63 5297 546673559 ERL85134.1 861 5.0e-89 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41535 BP_3 732.23 26.27 1635 546673559 ERL85134.1 400 4.4e-36 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41538 BP_3 785.99 6.25 6351 642915800 XP_008200083.1 3469 0.0e+00 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum] -- -- -- -- -- K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q62371 723 2.5e-74 Discoidin domain-containing receptor 2 OS=Mus musculus GN=Ddr2 PE=1 SV=2 PF09472//PF00069//PF07714 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Protein kinase domain//Protein tyrosine kinase GO:0015948//GO:0046656//GO:0006468 methanogenesis//folic acid biosynthetic process//protein phosphorylation GO:0030269//GO:0005524//GO:0004672 tetrahydromethanopterin S-methyltransferase activity//ATP binding//protein kinase activity GO:0016020 membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.4154 BP_3 8.00 0.71 838 307194022 EFN76535.1 400 2.3e-36 Histone-lysine N-methyltransferase SETMAR, partial [Harpegnathos saltator] -- -- -- -- -- K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q7JQ07 298 6.2e-26 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41540 BP_3 35.82 5.12 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10147 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 GO:0007049 cell cycle -- -- GO:0005634 nucleus -- -- Cluster-8309.41541 BP_3 117.04 5.97 1237 861599125 KMQ83546.1 410 2.3e-37 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16685 zinc RING finger of MSL2 -- -- GO:0061630 ubiquitin protein ligase activity -- -- -- -- Cluster-8309.41542 BP_3 63.00 10.21 589 607353959 EZA48640.1 163 4.8e-09 hypothetical protein X777_13603 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41543 BP_3 1052.87 11.90 4558 91084835 XP_966560.1 1369 5.3e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 6.5e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00892//PF13895//PF08449//PF04142//PF06027//PF00893//PF00114 EamA-like transporter family//Immunoglobulin domain//UAA transporter family//Nucleotide-sugar transporter//Solute carrier family 35//Small Multidrug Resistance protein//Pilin (bacterial filament) GO:0055085//GO:0006810//GO:0007155//GO:0008643 transmembrane transport//transport//cell adhesion//carbohydrate transport GO:0005351//GO:0005515 sugar:proton symporter activity//protein binding GO:0009289//GO:0016021//GO:0000139//GO:0016020 pilus//integral component of membrane//Golgi membrane//membrane KOG3912 Predicted integral membrane protein Cluster-8309.41544 BP_3 64.94 1.00 3423 91084835 XP_966560.1 1369 4.0e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 4.9e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00892//PF06027//PF08449//PF04142//PF00893 EamA-like transporter family//Solute carrier family 35//UAA transporter family//Nucleotide-sugar transporter//Small Multidrug Resistance protein GO:0055085//GO:0008643//GO:0006810 transmembrane transport//carbohydrate transport//transport GO:0005351 sugar:proton symporter activity GO:0016020//GO:0000139//GO:0016021 membrane//Golgi membrane//integral component of membrane KOG3912 Predicted integral membrane protein Cluster-8309.41545 BP_3 9.00 0.33 1621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.41546 BP_3 47.51 2.02 1423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07726 ATPase family associated with various cellular activities (AAA) -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- -- -- Cluster-8309.41548 BP_3 155.24 0.92 8394 642919607 XP_008191937.1 1817 1.1e-199 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X1 [Tribolium castaneum] 642919610 XM_970305.3 84 7.72051e-33 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X3, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 355 1.5e-31 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF04177//PF02257//PF12031 TAP42-like family//RFX DNA-binding domain//Domain of unknown function (DUF3518) GO:0009966//GO:0006355//GO:0006338 regulation of signal transduction//regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.41550 BP_3 3.50 0.78 508 642928911 XP_008195613.1 180 4.4e-11 PREDICTED: FK506-binding protein 5 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05190 MutS family domain IV GO:0006298 mismatch repair GO:0030983//GO:0005524 mismatched DNA binding//ATP binding -- -- -- -- Cluster-8309.41552 BP_3 447.22 3.04 7391 642922200 XP_008193059.1 2331 2.4e-259 PREDICTED: patronin isoform X6 [Tribolium castaneum] 645007691 XM_008218148.1 74 2.46087e-27 PREDICTED: Nasonia vitripennis patronin (LOC100118026), mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 1202 8.2e-130 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF00487//PF17095//PF00159//PF00307 Fatty acid desaturase//Spectrin-binding region of Ca2+-Calmodulin//Pancreatic hormone peptide//Calponin homology (CH) domain GO:0006629//GO:0007165//GO:0031175 lipid metabolic process//signal transduction//neuron projection development GO:0005179//GO:0005515//GO:0005516//GO:0030507 hormone activity//protein binding//calmodulin binding//spectrin binding GO:0005576//GO:0008091 extracellular region//spectrin KOG3654 Uncharacterized CH domain protein Cluster-8309.41553 BP_3 56.64 1.08 2812 198475573 XP_002132955.1 673 1.7e-67 GA26108 [Drosophila pseudoobscura pseudoobscura]>gi|198138883|gb|EDY70357.1| GA26108 [Drosophila pseudoobscura pseudoobscura] 194893319 XM_001977817.1 90 1.18514e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- Q8R4Y4 198 8.3e-14 Stabilin-1 OS=Mus musculus GN=Stab1 PE=1 SV=1 PF00558//PF07527//PF04882//PF00008 Vpu protein//Hairy Orange//Peroxin-3//EGF-like domain GO:0019076//GO:0007031//GO:0032801//GO:0006812//GO:0006355 viral release from host cell//peroxisome organization//receptor catabolic process//cation transport//regulation of transcription, DNA-templated GO:0005515//GO:0005261//GO:0003677 protein binding//cation channel activity//DNA binding GO:0005779//GO:0033644 integral component of peroxisomal membrane//host cell membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.41554 BP_3 153.11 9.07 1105 91090188 XP_966752.1 1317 1.4e-142 PREDICTED: tetraspanin-33 [Tribolium castaneum]>gi|270013472|gb|EFA09920.1| hypothetical protein TcasGA2_TC012071 [Tribolium castaneum] -- -- -- -- -- K17346 TSPAN33 tetraspanin-33 http://www.genome.jp/dbget-bin/www_bget?ko:K17346 Q8R3S2 559 4.5e-56 Tetraspanin-33 OS=Mus musculus GN=Tspan33 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.41555 BP_3 3656.61 70.10 2806 815792945 XP_012217083.1 2629 2.6e-294 PREDICTED: endoplasmin [Linepithema humile] 332376397 BT128381.1 574 0 Dendroctonus ponderosae clone DPO089_B16 unknown mRNA K09487 HSP90B, TRA1 heat shock protein 90kDa beta http://www.genome.jp/dbget-bin/www_bget?ko:K09487 Q22235 2113 7.2e-236 Endoplasmin homolog OS=Caenorhabditis elegans GN=enpl-1 PE=3 SV=1 PF15050//PF00183 SCIMP protein//Hsp90 protein GO:0006457//GO:0006950 protein folding//response to stress GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0001772//GO:0016021//GO:0097197 immunological synapse//integral component of membrane//tetraspanin-enriched microdomain KOG0020 Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family Cluster-8309.41556 BP_3 510.63 2.62 9688 642930211 XP_008196303.1 2794 0.0e+00 PREDICTED: protein aubergine [Tribolium castaneum]>gi|642930213|ref|XP_008196304.1| PREDICTED: protein aubergine [Tribolium castaneum]>gi|270010977|gb|EFA07425.1| piwi [Tribolium castaneum] 820846169 XM_003692874.2 149 6.55944e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 1693 1.3e-186 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF09494//PF07859//PF01764//PF15384//PF02186//PF02170//PF02230//PF02171//PF04636 Slx4 endonuclease//alpha/beta hydrolase fold//Lipase (class 3)//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//TFIIE beta subunit core domain//PAZ domain//Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin) GO:0008152//GO:0006281//GO:0006303//GO:0006629//GO:0006260//GO:0006308//GO:0006367//GO:1901031 metabolic process//DNA repair//double-strand break repair via nonhomologous end joining//lipid metabolic process//DNA replication//DNA catabolic process//transcription initiation from RNA polymerase II promoter//regulation of response to reactive oxygen species GO:0016787//GO:0017108//GO:0005515//GO:0003676 hydrolase activity//5'-flap endonuclease activity//protein binding//nucleic acid binding GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.41557 BP_3 304.58 1.54 9836 728417168 AIY68335.1 1997 1.7e-220 esterase, partial [Leptinotarsa decemlineata] 820846169 XM_003692874.2 149 6.66003e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 961 9.7e-102 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF04636//PF02171//PF02230//PF02186//PF02170//PF01764//PF15384//PF09494//PF07859 PA26 p53-induced protein (sestrin)//Piwi domain//Phospholipase/Carboxylesterase//TFIIE beta subunit core domain//PAZ domain//Lipase (class 3)//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//Slx4 endonuclease//alpha/beta hydrolase fold GO:0006260//GO:0006308//GO:0006367//GO:1901031//GO:0008152//GO:0006629//GO:0006281//GO:0006303 DNA replication//DNA catabolic process//transcription initiation from RNA polymerase II promoter//regulation of response to reactive oxygen species//metabolic process//lipid metabolic process//DNA repair//double-strand break repair via nonhomologous end joining GO:0003676//GO:0016787//GO:0017108//GO:0005515 nucleic acid binding//hydrolase activity//5'-flap endonuclease activity//protein binding GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.41558 BP_3 540.00 2.95 9118 270007552 EFA04000.1 501 4.8e-47 hypothetical protein TcasGA2_TC014149 [Tribolium castaneum] 462336464 APGK01037882.1 162 3.66242e-76 Dendroctonus ponderosae Seq01037892, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF06662 D-glucuronyl C5-epimerase C-terminus GO:0006024 glycosaminoglycan biosynthetic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016021 integral component of membrane -- -- Cluster-8309.41560 BP_3 237.16 2.28 5297 189240620 XP_001807833.1 1647 3.6e-180 PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|642933748|ref|XP_008191504.1| PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|270013625|gb|EFA10073.1| hypothetical protein TcasGA2_TC012247 [Tribolium castaneum] 242003577 XM_002422736.1 104 3.70563e-44 Pediculus humanus corporis hypothetical protein, mRNA -- -- -- -- Q02525 213 2.8e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.41561 BP_3 473.84 3.65 6553 189240620 XP_001807833.1 1647 4.5e-180 PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|642933748|ref|XP_008191504.1| PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|270013625|gb|EFA10073.1| hypothetical protein TcasGA2_TC012247 [Tribolium castaneum] 242003577 XM_002422736.1 104 4.58815e-44 Pediculus humanus corporis hypothetical protein, mRNA -- -- -- -- Q02525 213 3.5e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00096//PF00628 Zinc finger, C2H2 type//PHD-finger -- -- GO:0046872//GO:0005515//GO:0008270//GO:0003676 metal ion binding//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.41562 BP_3 2953.30 52.60 2998 780653487 XP_011691003.1 1373 1.2e-148 PREDICTED: pescadillo homolog [Wasmannia auropunctata] -- -- -- -- -- K14843 PES1, NOP7 pescadillo http://www.genome.jp/dbget-bin/www_bget?ko:K14843 B4KID9 1186 2.4e-128 Pescadillo homolog OS=Drosophila mojavensis GN=GI18209 PE=3 SV=1 PF06732 Pescadillo N-terminus GO:0042254 ribosome biogenesis -- -- GO:0005730 nucleolus KOG2481 Protein required for normal rRNA processing Cluster-8309.41563 BP_3 161.21 1.46 5616 91091668 XP_971563.1 1168 1.3e-124 PREDICTED: docking protein 2 [Tribolium castaneum]>gi|270001055|gb|EEZ97502.1| hypothetical protein TcasGA2_TC011346 [Tribolium castaneum] -- -- -- -- -- K17808 ZIM17, DNLZ, Tim15 mitochondrial protein import protein ZIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17808 A1L1P7 281 3.9e-23 DNL-type zinc finger protein OS=Danio rerio GN=dnlz PE=2 SV=1 PF05180//PF02174 DNL zinc finger//PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0008270//GO:0005158 zinc ion binding//insulin receptor binding GO:0005899 insulin receptor complex KOG3277 Uncharacterized conserved protein Cluster-8309.41564 BP_3 298.84 1.99 7538 642911773 XP_008200735.1 2249 8.0e-250 PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911775|ref|XP_008200736.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911777|ref|XP_008200737.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911779|ref|XP_008200738.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|270014735|gb|EFA11183.1| hypothetical protein TcasGA2_TC004791 [Tribolium castaneum] 397560823 JX204291.1 38 2.5821e-07 Sogatella furcifera membrane-bound trehalase mRNA, complete cds K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 A8J4S9 1814 9.1e-201 Trehalase OS=Apis mellifera PE=1 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.41565 BP_3 1494.23 39.31 2124 642934971 XP_008196003.1 1022 4.3e-108 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 142 1.10607e-65 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA -- -- -- -- -- -- -- -- PF03872 Anti sigma-E protein RseA, N-terminal domain -- -- GO:0016989 sigma factor antagonist activity -- -- -- -- Cluster-8309.41566 BP_3 257.52 7.76 1892 642934971 XP_008196003.1 1022 3.8e-108 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 142 9.83236e-66 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41568 BP_3 135.41 2.44 2963 642934971 XP_008196003.1 1255 5.7e-135 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] -- -- -- -- -- K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 Q80Z30 653 1.5e-66 Protein phosphatase 1E OS=Rattus norvegicus GN=Ppm1e PE=1 SV=1 PF00481//PF01006//PF01090//PF07228 Protein phosphatase 2C//Hepatitis C virus non-structural protein NS4a//Ribosomal protein S19e//Stage II sporulation protein E (SpoIIE) GO:0016032//GO:0042254//GO:0006412 viral process//ribosome biogenesis//translation GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0019012//GO:0005840 virion//ribosome KOG0698 Serine/threonine protein phosphatase Cluster-8309.4157 BP_3 4.52 0.46 763 861636785 KMQ91977.1 179 8.7e-11 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41570 BP_3 72.10 0.63 5828 642921963 XP_008192963.1 2164 4.4e-240 PREDICTED: uncharacterized protein LOC658725 [Tribolium castaneum]>gi|270007382|gb|EFA03830.1| hypothetical protein TcasGA2_TC013946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.41573 BP_3 484.80 7.24 3518 91079945 XP_968596.1 3239 0.0e+00 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003256|gb|EEZ99703.1| hypothetical protein TcasGA2_TC002464 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 2090 4.2e-233 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF07748//PF01074//PF09261 Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain//Alpha mannosidase, middle domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923//GO:0004559//GO:0004553//GO:0043169//GO:0008270 mannosidase activity//alpha-mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//zinc ion binding -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.41574 BP_3 7507.60 119.34 3324 91079945 XP_968596.1 3239 0.0e+00 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003256|gb|EEZ99703.1| hypothetical protein TcasGA2_TC002464 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 2090 4.0e-233 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF09261//PF01074//PF07748 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923//GO:0004559//GO:0004553//GO:0043169//GO:0008270 mannosidase activity//alpha-mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//zinc ion binding -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.41576 BP_3 33.38 0.48 3630 642932293 XP_008197052.1 354 2.1e-30 PREDICTED: epidermal growth factor-like protein 8 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3B748 196 1.8e-13 Protein LLP homolog OS=Danio rerio GN=llph PE=2 SV=1 PF05531//PF16326//PF00008//PF16331//PF11698//PF07361//PF08702//PF04799 Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//EGF-like domain//TolA binding protein trimerisation//V-ATPase subunit H//Cytochrome b562//Fibrinogen alpha/beta chain family//fzo-like conserved region GO:0070206//GO:0051258//GO:0007165//GO:0022900//GO:0006118//GO:0015991//GO:0030168//GO:0008053 protein trimerization//protein polymerization//signal transduction//electron transport chain//obsolete electron transport//ATP hydrolysis coupled proton transport//platelet activation//mitochondrial fusion GO:0003924//GO:0005506//GO:0005102//GO:0016820//GO:0005515//GO:0003677//GO:0020037//GO:0009055//GO:0030674 GTPase activity//iron ion binding//receptor binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//DNA binding//heme binding//electron carrier activity//protein binding, bridging GO:0019028//GO:0016021//GO:0005577//GO:0042597//GO:0000221//GO:0005741 viral capsid//integral component of membrane//fibrinogen complex//periplasmic space//vacuolar proton-transporting V-type ATPase, V1 domain//mitochondrial outer membrane -- -- Cluster-8309.41577 BP_3 4.11 0.93 505 91076410 XP_969526.1 402 8.0e-37 PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002563|gb|EEZ99010.1| hypothetical protein TcasGA2_TC004878 [Tribolium castaneum] 731510745 XM_010600440.1 48 4.49131e-14 PREDICTED: Loxodonta africana aldose reductase-related protein 2-like (LOC100673621), mRNA K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 317 2.4e-28 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.41578 BP_3 1506.64 49.29 1765 254911123 NP_001157182.1 945 3.0e-99 cactus isoform 2 [Tribolium castaneum]>gi|270016252|gb|EFA12698.1| cactus [Tribolium castaneum] -- -- -- -- -- K09259 K09259 ankyrin only family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09259 Q03017 521 1.8e-51 NF-kappa-B inhibitor cactus OS=Drosophila melanogaster GN=cact PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41581 BP_3 398.00 6.13 3423 91091382 XP_973347.1 987 7.9e-104 PREDICTED: fibroblast growth factor receptor substrate 3 [Tribolium castaneum]>gi|270013059|gb|EFA09507.1| hypothetical protein TcasGA2_TC011609 [Tribolium castaneum] -- -- -- -- -- K12461 FRS2 fibroblast growth factor receptor substrate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12461 Q8C180 275 1.2e-22 Fibroblast growth factor receptor substrate 2 OS=Mus musculus GN=Frs2 PE=1 SV=3 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.41582 BP_3 356.03 5.37 3490 189234059 XP_969658.2 2716 2.6e-304 PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|642911998|ref|XP_008199054.1| PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|270014437|gb|EFA10885.1| hypothetical protein TcasGA2_TC001709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TWI9 1057 2.5e-113 CSC1-like protein 2 OS=Mus musculus GN=Tmem63b PE=1 SV=1 PF02714 Calcium-dependent channel, 7TM region, putative phosphate -- -- -- -- GO:0016020 membrane KOG1134 Uncharacterized conserved protein Cluster-8309.41584 BP_3 26.12 0.42 3264 642922164 XP_008193042.1 2416 1.5e-269 PREDICTED: glycine--tRNA ligase [Tribolium castaneum] 170050074 XM_001859151.1 174 2.77934e-83 Culex quinquefasciatus glycyl-tRNA synthetase, mRNA K01880 GARS, glyS1 glycyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01880 Q04451 2067 1.8e-230 Glycine--tRNA ligase OS=Bombyx mori PE=1 SV=2 PF00458//PF00587 WHEP-TRS domain//tRNA synthetase class II core domain (G, H, P, S and T) GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity -- -- KOG2298 Glycyl-tRNA synthetase and related class II tRNA synthetase Cluster-8309.41586 BP_3 75.00 1.37 2922 642931096 XP_974337.3 498 3.4e-47 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWU1 342 1.7e-30 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41587 BP_3 2882.18 21.63 6714 478261414 ENN80791.1 4569 0.0e+00 hypothetical protein YQE_02800, partial [Dendroctonus ponderosae]>gi|546680987|gb|ERL91161.1| hypothetical protein D910_08501 [Dendroctonus ponderosae] 815771795 XM_012380628.1 476 0 PREDICTED: Linepithema humile ATP-dependent helicase brm (LOC105680160), mRNA K11647 SMARCA2_4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K11647 Q3TKT4 3297 0.0e+00 Transcription activator BRG1 OS=Mus musculus GN=Smarca4 PE=1 SV=1 PF00176//PF07533//PF14619//PF04851//PF00270//PF00439//PF08880 SNF2 family N-terminal domain//BRK domain//Snf2-ATP coupling, chromatin remodelling complex//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Bromodomain//QLQ GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0042393//GO:0016817//GO:0005524//GO:0016787//GO:0003677//GO:0005515 nucleic acid binding//histone binding//hydrolase activity, acting on acid anhydrides//ATP binding//hydrolase activity//DNA binding//protein binding GO:0005634 nucleus KOG0386 Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) Cluster-8309.41588 BP_3 1862.23 13.06 7166 478263704 ENN82007.1 2238 1.4e-248 hypothetical protein YQE_01582, partial [Dendroctonus ponderosae]>gi|546671060|gb|ERL83542.1| hypothetical protein D910_00613 [Dendroctonus ponderosae]>gi|546672516|gb|ERL84345.1| hypothetical protein D910_01767 [Dendroctonus ponderosae] -- -- -- -- -- K03544 clpX, CLPX ATP-dependent Clp protease ATP-binding subunit ClpX http://www.genome.jp/dbget-bin/www_bget?ko:K03544 Q5U2U0 1533 3.3e-168 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Rattus norvegicus GN=Clpx PE=2 SV=1 PF06068//PF00158//PF01057//PF05496//PF07728//PF01695//PF14532//PF07724//PF00004//PF00437//PF02367//PF02562//PF00005//PF10662//PF00270 TIP49 C-terminus//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ABC transporter//Ethanolamine utilisation - propanediol utilisation//DEAD/DEAH box helicase GO:0019079//GO:0006281//GO:0006810//GO:0006355//GO:0006576//GO:0006310//GO:0002949 viral genome replication//DNA repair//transport//regulation of transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0008134//GO:0016887//GO:0003678//GO:0003676//GO:0009378 ATP binding//transcription factor binding//ATPase activity//DNA helicase activity//nucleic acid binding//four-way junction helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0745 Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) Cluster-8309.41590 BP_3 66.50 1.64 2250 189235662 XP_001811794.1 1463 3.3e-159 PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum]>gi|642917553|ref|XP_008191254.1| PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41594 BP_3 225.56 5.51 2265 546673600 ERL85164.1 1732 2.1e-190 hypothetical protein D910_02586 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q14728 936 1.8e-99 Major facilitator superfamily domain-containing protein 10 OS=Homo sapiens GN=MFSD10 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2615 Permease of the major facilitator superfamily Cluster-8309.41595 BP_3 168.44 2.91 3078 546673600 ERL85164.1 1729 6.5e-190 hypothetical protein D910_02586 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q14728 936 2.4e-99 Major facilitator superfamily domain-containing protein 10 OS=Homo sapiens GN=MFSD10 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2615 Permease of the major facilitator superfamily Cluster-8309.41596 BP_3 403.99 2.52 8019 270007809 EFA04257.1 634 1.6e-62 hypothetical protein TcasGA2_TC014547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IIG7 207 2.1e-14 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF00612//PF04644 IQ calmodulin-binding motif//Motilin/ghrelin GO:0007165 signal transduction GO:0005515//GO:0005179 protein binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.41597 BP_3 88.95 0.55 8099 642923994 XP_967135.2 369 8.6e-32 PREDICTED: microtubule-associated protein futsch-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IIG7 207 2.2e-14 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF00612//PF04644 IQ calmodulin-binding motif//Motilin/ghrelin GO:0007165 signal transduction GO:0005515//GO:0005179 protein binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.41599 BP_3 11.00 0.49 1380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- O74423 136 6.3e-07 Epsin-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ent1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.416 BP_3 8.00 0.73 818 -- -- -- -- -- 404312704 AC253548.1 718 0 Prunus persica clone JGIBIXB-13B9, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41600 BP_3 47.00 2.21 1319 270015247 EFA11695.1 808 1.7e-83 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.41601 BP_3 65.43 0.95 3621 270014679 EFA11127.1 421 3.6e-38 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 256 2.0e-20 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41603 BP_3 458.97 2.38 9581 91087223 XP_975486.1 6932 0.0e+00 PREDICTED: probable Rho GTPase-activating protein CG5521 isoform X2 [Tribolium castaneum] 642929668 XM_970393.2 238 2.17369e-118 PREDICTED: Tribolium castaneum probable Rho GTPase-activating protein CG5521 (LOC664386), transcript variant X2, mRNA -- -- -- -- Q9VB98 2114 1.9e-235 Probable Rho GTPase-activating protein CG5521 OS=Drosophila melanogaster GN=CG5521 PE=1 SV=2 PF01155//PF00130//PF03110//PF04135//PF03367//PF02145 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//SBP domain//Nucleolar RNA-binding protein, Nop10p family//ZPR1 zinc-finger domain//Rap/ran-GAP GO:0006464//GO:0051056//GO:0042254//GO:0035556//GO:0001522 cellular protein modification process//regulation of small GTPase mediated signal transduction//ribosome biogenesis//intracellular signal transduction//pseudouridine synthesis GO:0003677//GO:0005096//GO:0030515//GO:0016151//GO:0008270 DNA binding//GTPase activator activity//snoRNA binding//nickel cation binding//zinc ion binding GO:0072588//GO:0005634 box H/ACA RNP complex//nucleus KOG2703 C4-type Zn-finger protein Cluster-8309.41604 BP_3 593.61 3.06 9656 642929667 XP_008195928.1 6933 0.0e+00 PREDICTED: probable Rho GTPase-activating protein CG5521 isoform X1 [Tribolium castaneum] 642929668 XM_970393.2 238 2.19077e-118 PREDICTED: Tribolium castaneum probable Rho GTPase-activating protein CG5521 (LOC664386), transcript variant X2, mRNA -- -- -- -- Q9VB98 2113 2.5e-235 Probable Rho GTPase-activating protein CG5521 OS=Drosophila melanogaster GN=CG5521 PE=1 SV=2 PF03367//PF02145//PF01155//PF00130//PF03110//PF04135 ZPR1 zinc-finger domain//Rap/ran-GAP//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//SBP domain//Nucleolar RNA-binding protein, Nop10p family GO:0006464//GO:0042254//GO:0001522//GO:0035556//GO:0051056 cellular protein modification process//ribosome biogenesis//pseudouridine synthesis//intracellular signal transduction//regulation of small GTPase mediated signal transduction GO:0016151//GO:0030515//GO:0003677//GO:0005096//GO:0008270 nickel cation binding//snoRNA binding//DNA binding//GTPase activator activity//zinc ion binding GO:0005634//GO:0072588 nucleus//box H/ACA RNP complex KOG2703 C4-type Zn-finger protein Cluster-8309.41606 BP_3 2571.51 14.01 9136 91085247 XP_973234.1 3413 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 316 9.0469e-162 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 2247 6.8e-251 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF00015//PF02985//PF08064//PF11698//PF05997//PF14372//PF06009//PF07690//PF00083 Methyl-accepting chemotaxis protein (MCP) signalling domain//HEAT repeat//UME (NUC010) domain//V-ATPase subunit H//Nucleolar protein,Nop52//Domain of unknown function (DUF4413)//Laminin Domain II//Major Facilitator Superfamily//Sugar (and other) transporter GO:0006364//GO:0055085//GO:0007165//GO:0009069//GO:0007155//GO:0016310//GO:0015991 rRNA processing//transmembrane transport//signal transduction//serine family amino acid metabolic process//cell adhesion//phosphorylation//ATP hydrolysis coupled proton transport GO:0004674//GO:0004871//GO:0003677//GO:0022857//GO:0016820//GO:0005515 protein serine/threonine kinase activity//signal transducer activity//DNA binding//transmembrane transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0030688//GO:0016021//GO:0016020//GO:0000221 preribosome, small subunit precursor//integral component of membrane//membrane//vacuolar proton-transporting V-type ATPase, V1 domain KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.41607 BP_3 170.88 3.66 2544 91090674 XP_974487.1 2441 1.5e-272 PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|642935631|ref|XP_008198090.1| PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|642935634|ref|XP_008198091.1| PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|270013933|gb|EFA10381.1| hypothetical protein TcasGA2_TC012612 [Tribolium castaneum] 665801709 XM_008550658.1 129 2.23876e-58 PREDICTED: Microplitis demolitor D-glucuronyl C5-epimerase (LOC103572179), mRNA K01793 GLCE heparosan-N-sulfate-glucuronate 5-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01793 Q9EPS3 1331 3.1e-145 D-glucuronyl C5-epimerase OS=Mus musculus GN=Glce PE=1 SV=2 PF11734//PF09115//PF06662 TilS substrate C-terminal domain//DNA polymerase III, delta subunit, C terminal//D-glucuronyl C5-epimerase C-terminus GO:0006024//GO:0008033//GO:0006260 glycosaminoglycan biosynthetic process//tRNA processing//DNA replication GO:0003887//GO:0016879//GO:0016857//GO:0003677//GO:0005524//GO:0000166 DNA-directed DNA polymerase activity//ligase activity, forming carbon-nitrogen bonds//racemase and epimerase activity, acting on carbohydrates and derivatives//DNA binding//ATP binding//nucleotide binding GO:0042575//GO:0009360//GO:0016021//GO:0005737 DNA polymerase complex//DNA polymerase III complex//integral component of membrane//cytoplasm KOG3760 Heparan sulfate-glucuronic acid C5-epimerase Cluster-8309.41608 BP_3 32.23 0.72 2454 642921818 XP_008199331.1 1159 6.4e-124 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] -- -- -- -- -- K10106 GGCX vitamin K-dependent gamma-carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10106 Q9MYY3 684 3.2e-70 Vitamin K-dependent gamma-carboxylase OS=Delphinapterus leucas GN=GGCX PE=2 SV=1 PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.41609 BP_3 118.70 1.26 4818 642931172 XP_008196469.1 2267 4.2e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41610 BP_3 97.96 4.07 1451 189239889 XP_969643.2 569 9.9e-56 PREDICTED: uncharacterized protein LOC658141 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41612 BP_3 65.64 1.74 2112 642915063 XP_008190394.1 900 6.0e-94 PREDICTED: acyl-CoA dehydrogenase family member 9, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZN5 380 4.9e-35 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 PF02770//PF02771//PF00441//PF09057 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain//Second Mitochondria-derived Activator of Caspases GO:0008152//GO:0006915//GO:0055114//GO:0006919//GO:0006118 metabolic process//apoptotic process//oxidation-reduction process//activation of cysteine-type endopeptidase activity involved in apoptotic process//obsolete electron transport GO:0003995//GO:0016627//GO:0050660 acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding GO:0005739 mitochondrion KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.41613 BP_3 25.04 0.51 2646 642923366 XP_973695.2 486 7.6e-46 PREDICTED: uncharacterized protein LOC662511 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41617 BP_3 1099.33 11.97 4720 270004796 EFA01244.1 1297 1.2e-139 sprouty-related protein with EVH-1 domain [Tribolium castaneum] 237823395 AB443867.1 36 2.08642e-06 Culex quinquefasciatus CqGSTd1 gene for glutathione transferase, complete cds, alternative splicing K04703 SPRED sprouty-related, EVH1 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04703 Q66JG9 467 8.9e-45 Sprouty-related, EVH1 domain-containing protein 1 OS=Xenopus tropicalis GN=spred1 PE=1 SV=1 PF02798//PF13417//PF05210//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Sprouty protein (Spry)//Glutathione S-transferase, N-terminal domain GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.41618 BP_3 31.59 1.06 1732 557771007 XP_005185166.1 383 4.4e-34 PREDICTED: glutathione S-transferase 1-like [Musca domestica] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 329 3.3e-29 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.4162 BP_3 3.57 0.46 670 478253167 ENN73538.1 381 2.9e-34 hypothetical protein YQE_09789, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2M3X9 129 2.0e-06 Zinc finger protein 674 OS=Homo sapiens GN=ZNF674 PE=2 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.41620 BP_3 349.82 2.89 6126 642918795 XP_008191588.1 293 4.2e-23 PREDICTED: uncharacterized protein LOC103312529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41621 BP_3 2257.59 25.92 4490 91086569 XP_973078.1 2043 3.7e-226 PREDICTED: E3 ubiquitin-protein ligase AMFR-like [Tribolium castaneum] -- -- -- -- -- K10636 AMFR, GP78 autocrine motility factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10636 Q9UKV5 1150 5.4e-124 E3 ubiquitin-protein ligase AMFR OS=Homo sapiens GN=AMFR PE=1 SV=2 PF02537//PF14634//PF12906//PF17123//PF12678//PF00097//PF17122//PF13639//PF12861//PF02845 CrcB-like protein, Camphor Resistance (CrcB)//zinc-RING finger domain//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//CUE domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680//GO:0016021 anaphase-promoting complex//integral component of membrane KOG0802 E3 ubiquitin ligase Cluster-8309.41622 BP_3 85.83 0.85 5136 91086569 XP_973078.1 1869 6.3e-206 PREDICTED: E3 ubiquitin-protein ligase AMFR-like [Tribolium castaneum] -- -- -- -- -- K10636 AMFR, GP78 autocrine motility factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10636 Q9UKV5 1125 4.9e-121 E3 ubiquitin-protein ligase AMFR OS=Homo sapiens GN=AMFR PE=1 SV=2 PF00097//PF17122//PF02537//PF14634//PF12678//PF12906//PF17123//PF00895//PF13639//PF02845//PF12861 Zinc finger, C3HC4 type (RING finger)//Zinc-finger//CrcB-like protein, Camphor Resistance (CrcB)//zinc-RING finger domain//RING-H2 zinc finger//RING-variant domain//RING-like zinc finger//ATP synthase protein 8//Ring finger domain//CUE domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567//GO:0015986//GO:0015992 protein ubiquitination//ATP synthesis coupled proton transport//proton transport GO:0005515//GO:0004842//GO:0015078//GO:0008270//GO:0046872 protein binding//ubiquitin-protein transferase activity//hydrogen ion transmembrane transporter activity//zinc ion binding//metal ion binding GO:0016021//GO:0005680//GO:0000276 integral component of membrane//anaphase-promoting complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG0802 E3 ubiquitin ligase Cluster-8309.41624 BP_3 630.29 12.22 2778 557876145 AHA39267.1 269 1.2e-20 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395//PF02391//PF02522//PF15234 PBP/GOBP family//MoaE protein//Aminoglycoside 3-N-acetyltransferase//Linker for activation of T-cells GO:0042967//GO:0006777//GO:0046677//GO:0007165 acyl-carrier-protein biosynthetic process//Mo-molybdopterin cofactor biosynthetic process//response to antibiotic//signal transduction GO:0005549//GO:0046353 odorant binding//aminoglycoside 3-N-acetyltransferase activity GO:0016020 membrane -- -- Cluster-8309.41626 BP_3 1008.00 10.89 4755 780140340 XP_011680553.1 564 1.2e-54 PREDICTED: titin [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q23551 541 2.4e-53 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF00041//PF13895//PF00319//PF16656 Fibronectin type III domain//Immunoglobulin domain//SRF-type transcription factor (DNA-binding and dimerisation domain)//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0046983//GO:0003677//GO:0003993 metal ion binding//protein binding//protein dimerization activity//DNA binding//acid phosphatase activity -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.41627 BP_3 2039.00 16.35 6303 91090504 XP_975968.1 873 2.4e-90 PREDICTED: ribonuclease Oy [Tribolium castaneum]>gi|270013355|gb|EFA09803.1| hypothetical protein TcasGA2_TC011946 [Tribolium castaneum] -- -- -- -- -- K01166 E3.1.27.1 ribonuclease T2 http://www.genome.jp/dbget-bin/www_bget?ko:K01166 Q7M456 400 7.0e-37 Ribonuclease Oy OS=Crassostrea gigas PE=1 SV=1 PF00445 Ribonuclease T2 family -- -- GO:0033897//GO:0003723 ribonuclease T2 activity//RNA binding -- -- KOG1642 Ribonuclease, T2 family Cluster-8309.41628 BP_3 28.36 0.79 2015 478253752 ENN74046.1 716 1.2e-72 hypothetical protein YQE_09337, partial [Dendroctonus ponderosae] 268574973 XM_002642420.1 86 1.41495e-34 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 601 1.1e-60 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF01517//PF16326//PF04111//PF01496//PF00769 Hepatitis delta virus delta antigen//ABC transporter C-terminal domain//Autophagy protein Apg6//V-type ATPase 116kDa subunit family//Ezrin/radixin/moesin family GO:0015992//GO:0015991//GO:0006914 proton transport//ATP hydrolysis coupled proton transport//autophagy GO:0015078//GO:0003677//GO:0003723//GO:0008092 hydrogen ion transmembrane transporter activity//DNA binding//RNA binding//cytoskeletal protein binding GO:0005737//GO:0033179//GO:0042025//GO:0019898 cytoplasm//proton-transporting V-type ATPase, V0 domain//host cell nucleus//extrinsic component of membrane KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.41632 BP_3 377.47 4.80 4085 91077414 XP_975386.1 1918 1.0e-211 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 5.3e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF12634//PF13414//PF02782//PF06723//PF00516//PF15281 Inheritance of peroxisomes protein 1//TPR repeat//FGGY family of carbohydrate kinases, C-terminal domain//MreB/Mbl protein//Envelope glycoprotein GP120//Consortin C-terminus GO:0042998//GO:0006457//GO:0005975//GO:0000902//GO:0045033 positive regulation of Golgi to plasma membrane protein transport//protein folding//carbohydrate metabolic process//cell morphogenesis//peroxisome inheritance GO:0005515//GO:0071253//GO:0005524//GO:0016773//GO:0051082 protein binding//connexin binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//unfolded protein binding GO:0005802//GO:0019031//GO:0005780 trans-Golgi network//viral envelope//extrinsic component of intraperoxisomal membrane KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.41633 BP_3 248.40 3.33 3883 478256593 ENN76775.1 3637 0.0e+00 hypothetical protein YQE_06616, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8CFG5 1356 6.0e-148 Voltage-dependent calcium channel subunit alpha-2/delta-3 OS=Rattus norvegicus GN=Cacna2d3 PE=1 SV=1 PF08030 Ferric reductase NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.41634 BP_3 968.68 19.21 2722 642921258 XP_008192788.1 1737 6.8e-191 PREDICTED: serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [Tribolium castaneum] 597735941 XM_007230177.1 329 1.58522e-169 PREDICTED: Astyanax mexicanus serine/threonine-protein phosphatase PP1-beta catalytic subunit-like (LOC103033313), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q5I085 1654 1.2e-182 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Xenopus tropicalis GN=ppp1cb PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.41636 BP_3 1726.77 6.80 12527 642914032 XP_008201515.1 5554 0.0e+00 PREDICTED: syntaxin-binding protein 5 isoform X2 [Tribolium castaneum] 751777385 XM_011199394.1 86 8.91998e-34 PREDICTED: Bactrocera dorsalis probable ATP-dependent RNA helicase DDX10 (LOC105222182), mRNA K08518 STXBP5 syntaxin-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08518 Q9WU70 2011 2.2e-223 Syntaxin-binding protein 5 OS=Rattus norvegicus GN=Stxbp5 PE=1 SV=1 PF00802//PF11616//PF00957//PF00270//PF01218//PF11427//PF04992//PF00400 Pneumovirus attachment glycoprotein G//WD repeat binding protein EZH2//Synaptobrevin//DEAD/DEAH box helicase//Coproporphyrinogen III oxidase//Tc3 transposase//RNA polymerase Rpb1, domain 6//WD domain, G-beta repeat GO:0006206//GO:0006479//GO:0015994//GO:0006144//GO:0006351//GO:0055114//GO:0006554//GO:0006779//GO:0016192 pyrimidine nucleobase metabolic process//protein methylation//chlorophyll metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//lysine catabolic process//porphyrin-containing compound biosynthetic process//vesicle-mediated transport GO:0003676//GO:0005515//GO:0004109//GO:0003677//GO:0018024//GO:0005524//GO:0003899 nucleic acid binding//protein binding//coproporphyrinogen oxidase activity//DNA binding//histone-lysine N-methyltransferase activity//ATP binding//DNA-directed RNA polymerase activity GO:0005730//GO:0055036//GO:0016021 nucleolus//virion membrane//integral component of membrane KOG0343 RNA Helicase Cluster-8309.41637 BP_3 2246.54 101.65 1357 270010528 EFA06976.1 217 6.0e-15 hypothetical protein TcasGA2_TC009936 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y7Y3 141 1.6e-07 Uncharacterized RNA-binding protein C365.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC365.04c PE=3 SV=1 PF00076//PF04449//PF03153 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//CS1 type fimbrial major subunit//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0003676 nucleic acid binding GO:0009289//GO:0005672 pilus//transcription factor TFIIA complex -- -- Cluster-8309.41638 BP_3 535.73 33.79 1056 642928066 XP_008200141.1 174 4.6e-10 PREDICTED: serine protease inhibitor I/II-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- -- -- Cluster-8309.41640 BP_3 247.00 4.83 2756 270005740 EFA02188.1 4069 0.0e+00 hypothetical protein TcasGA2_TC007844 [Tribolium castaneum] 768430832 XM_011558359.1 42 5.59722e-10 PREDICTED: Plutella xylostella teneurin-a (LOC105387609), partial mRNA -- -- -- -- Q9VYN8 3168 0.0e+00 Teneurin-a OS=Drosophila melanogaster GN=Ten-a PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41642 BP_3 614.46 3.22 9494 91084029 XP_966465.1 4108 0.0e+00 PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|642924795|ref|XP_008194044.1| PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270006700|gb|EFA03148.1| hypothetical protein TcasGA2_TC013061 [Tribolium castaneum] 440199242 JQ783618.1 203 6.16046e-99 Schreckensteinia sp. Sktn ala-tRNA synthetase mRNA, partial cds K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VLM8 3510 0.0e+00 Alanine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-ala PE=2 SV=1 PF00071//PF01580//PF00493//PF02272//PF01411//PF01018//PF03193//PF00400//PF00005//PF01399//PF00025//PF02421//PF01343//PF07973//PF01926 Ras family//FtsK/SpoIIIE family//MCM2/3/5 family//DHHA1 domain//tRNA synthetases class II (A)//GTP1/OBG//Protein of unknown function, DUF258//WD domain, G-beta repeat//ABC transporter//PCI domain//ADP-ribosylation factor family//Ferrous iron transport protein B//Peptidase family S49//Threonyl and Alanyl tRNA synthetase second additional domain//50S ribosome-binding GTPase GO:0043039//GO:0007264//GO:0006413//GO:0006508//GO:0006522//GO:0006446//GO:0006531//GO:0006419//GO:0015684//GO:0006260 tRNA aminoacylation//small GTPase mediated signal transduction//translational initiation//proteolysis//alanine metabolic process//regulation of translational initiation//aspartate metabolic process//alanyl-tRNA aminoacylation//ferrous iron transport//DNA replication GO:0003676//GO:0005525//GO:0005515//GO:0004813//GO:0003677//GO:0015093//GO:0016876//GO:0008233//GO:0016887//GO:0000166//GO:0003924//GO:0003743//GO:0005524 nucleic acid binding//GTP binding//protein binding//alanine-tRNA ligase activity//DNA binding//ferrous iron transmembrane transporter activity//ligase activity, forming aminoacyl-tRNA and related compounds//peptidase activity//ATPase activity//nucleotide binding//GTPase activity//translation initiation factor activity//ATP binding GO:0005737//GO:0005840//GO:0016021 cytoplasm//ribosome//integral component of membrane KOG0188 Alanyl-tRNA synthetase Cluster-8309.41643 BP_3 188.00 30.89 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41644 BP_3 41.17 8.88 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41646 BP_3 73.95 9.18 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41649 BP_3 96.66 4.68 1288 642915266 XP_971845.3 865 4.2e-90 PREDICTED: sorting nexin-16 [Tribolium castaneum]>gi|270003912|gb|EFA00360.1| hypothetical protein TcasGA2_TC003202 [Tribolium castaneum] -- -- -- -- -- K17928 SNX16 sorting nexin-16 http://www.genome.jp/dbget-bin/www_bget?ko:K17928 P57768 338 2.2e-30 Sorting nexin-16 OS=Homo sapiens GN=SNX16 PE=1 SV=2 PF00787//PF08702 PX domain//Fibrinogen alpha/beta chain family GO:0030168//GO:0007165//GO:0051258 platelet activation//signal transduction//protein polymerization GO:0005102//GO:0030674//GO:0035091 receptor binding//protein binding, bridging//phosphatidylinositol binding GO:0005577 fibrinogen complex -- -- Cluster-8309.41651 BP_3 18.00 6.38 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41652 BP_3 75.91 1.65 2507 332375600 AEE62941.1 1142 6.2e-122 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7T3C7 340 2.5e-30 Reticulon-4-interacting protein 1 homolog, mitochondrial OS=Danio rerio GN=rtn4ip1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.41655 BP_3 272.60 2.12 6487 642937213 XP_008198742.1 1493 3.2e-162 PREDICTED: activin receptor type-2A [Tribolium castaneum]>gi|270001287|gb|EEZ97734.1| punt [Tribolium castaneum] 852789879 XM_013030253.1 144 2.63839e-66 PREDICTED: Dipodomys ordii activin A receptor, type IIB (Acvr2b), mRNA K13596 ACVR2B activin receptor type-2B http://www.genome.jp/dbget-bin/www_bget?ko:K13596 P27039 1135 4.2e-122 Activin receptor type-2A OS=Xenopus laevis GN=acvr2a PE=2 SV=1 PF16782//PF01064//PF00069//PF07714//PF08917 Nucleotide exchange factor SIL1//Activin types I and II receptor domain//Protein kinase domain//Protein tyrosine kinase//Transforming growth factor beta receptor 2 ectodomain GO:0032924//GO:0016310//GO:0007178//GO:0009069//GO:0023014//GO:0006468 activin receptor signaling pathway//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//serine family amino acid metabolic process//signal transduction by protein phosphorylation//protein phosphorylation GO:0004675//GO:0005024//GO:0004672//GO:0046872//GO:0017002//GO:0000774//GO:0005026//GO:0004702//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//transforming growth factor beta-activated receptor activity//protein kinase activity//metal ion binding//activin-activated receptor activity//adenyl-nucleotide exchange factor activity//transforming growth factor beta receptor activity, type II//receptor signaling protein serine/threonine kinase activity//ATP binding GO:0016020//GO:0005783//GO:0048179 membrane//endoplasmic reticulum//activin receptor complex -- -- Cluster-8309.41657 BP_3 565.13 4.85 5909 546683250 ERL93082.1 1097 2.4e-116 hypothetical protein D910_10384 [Dendroctonus ponderosae] 597773854 XM_007250594.1 78 1.17483e-29 PREDICTED: Astyanax mexicanus activin receptor type-2A-like (LOC103032572), transcript variant X4, mRNA K13596 ACVR2B activin receptor type-2B http://www.genome.jp/dbget-bin/www_bget?ko:K13596 P27039 654 2.3e-66 Activin receptor type-2A OS=Xenopus laevis GN=acvr2a PE=2 SV=1 PF07714//PF16782//PF01064//PF00069 Protein tyrosine kinase//Nucleotide exchange factor SIL1//Activin types I and II receptor domain//Protein kinase domain GO:0007178//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0000774//GO:0004675//GO:0004672//GO:0005524 adenyl-nucleotide exchange factor activity//transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020//GO:0005783 membrane//endoplasmic reticulum -- -- Cluster-8309.41659 BP_3 1134.46 6.90 8220 642917011 XP_008199595.1 1252 3.5e-134 PREDICTED: probable ATP-dependent RNA helicase DHX35 [Tribolium castaneum] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.2e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF04548//PF02183//PF17078//PF15458//PF07989//PF00005//PF03193//PF05529//PF01066//PF00437//PF04632//PF00503//PF01166//PF03824//PF06005//PF04111//PF06156 AIG1 family//Homeobox associated leucine zipper//SWI5-dependent HO expression protein 3//Nineteen complex-related protein 2//Centrosomin N-terminal motif 1//ABC transporter//Protein of unknown function, DUF258//B-cell receptor-associated protein 31-like//CDP-alcohol phosphatidyltransferase//Type II/IV secretion system protein//Fusaric acid resistance protein family//G-protein alpha subunit//TSC-22/dip/bun family//High-affinity nickel-transport protein//Protein of unknown function (DUF904)//Autophagy protein Apg6//Protein of unknown function (DUF972) GO:0006260//GO:0035444//GO:0048309//GO:0051028//GO:0000390//GO:0007186//GO:0006355//GO:0015675//GO:0007165//GO:0006886//GO:0006810//GO:0006914//GO:0000917//GO:0008654//GO:0043093 DNA replication//nickel cation transmembrane transport//endoplasmic reticulum inheritance//mRNA transport//spliceosomal complex disassembly//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//nickel cation transport//signal transduction//intracellular protein transport//transport//autophagy//barrier septum assembly//phospholipid biosynthetic process//FtsZ-dependent cytokinesis GO:0016887//GO:0019001//GO:0003700//GO:0031683//GO:0005524//GO:0003924//GO:0046872//GO:0043565//GO:0004871//GO:0005525//GO:0015099//GO:0016780 ATPase activity//guanyl nucleotide binding//transcription factor activity, sequence-specific DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//metal ion binding//sequence-specific DNA binding//signal transducer activity//GTP binding//nickel cation transmembrane transporter activity//phosphotransferase activity, for other substituted phosphate groups GO:0071008//GO:0005667//GO:0005737//GO:0005815//GO:0016021//GO:0016020//GO:0005886//GO:0005783 U2-type post-mRNA release spliceosomal complex//transcription factor complex//cytoplasm//microtubule organizing center//integral component of membrane//membrane//plasma membrane//endoplasmic reticulum KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.4166 BP_3 11.00 1.77 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41661 BP_3 276.40 14.31 1223 478251161 ENN71637.1 613 6.6e-61 hypothetical protein YQE_11735, partial [Dendroctonus ponderosae]>gi|546685822|gb|ERL95265.1| hypothetical protein D910_12531 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15278 230 7.0e-18 Fasciclin-3 OS=Drosophila melanogaster GN=Fas3 PE=2 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41664 BP_3 478.28 3.90 6208 642914669 XP_008190307.1 3009 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.47207e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.7e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41665 BP_3 997.80 23.15 2369 91090079 XP_969933.1 1422 2.0e-154 PREDICTED: twinfilin [Tribolium castaneum]>gi|270013504|gb|EFA09952.1| hypothetical protein TcasGA2_TC012105 [Tribolium castaneum] -- -- -- -- -- K08870 TWF twinfilin http://www.genome.jp/dbget-bin/www_bget?ko:K08870 Q17A58 1087 5.7e-117 Twinfilin OS=Aedes aegypti GN=twf PE=3 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein Cluster-8309.41666 BP_3 37.23 0.80 2536 91090079 XP_969933.1 1122 1.3e-119 PREDICTED: twinfilin [Tribolium castaneum]>gi|270013504|gb|EFA09952.1| hypothetical protein TcasGA2_TC012105 [Tribolium castaneum] -- -- -- -- -- K08870 TWF twinfilin http://www.genome.jp/dbget-bin/www_bget?ko:K08870 Q17A58 832 2.3e-87 Twinfilin OS=Aedes aegypti GN=twf PE=3 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein Cluster-8309.41667 BP_3 267.00 2.14 6293 91091970 XP_968583.1 1843 8.0e-203 PREDICTED: synaptotagmin-11 [Tribolium castaneum]>gi|270001306|gb|EEZ97753.1| synaptotagmin IV [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BT88 786 1.2e-81 Synaptotagmin-11 OS=Homo sapiens GN=SYT11 PE=1 SV=2 PF00168//PF03585 C2 domain//Herpesvirus ICP4-like protein C-terminal region GO:0045893//GO:0006810 positive regulation of transcription, DNA-templated//transport GO:0005215//GO:0005515 transporter activity//protein binding GO:0042025//GO:0016020//GO:0008021 host cell nucleus//membrane//synaptic vesicle KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.41668 BP_3 129.56 1.97 3467 642930224 XP_008196307.1 2166 1.6e-240 PREDICTED: probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [Tribolium castaneum] 543271752 XM_005425019.1 98 5.23113e-41 PREDICTED: Geospiza fortis methylcrotonoyl-CoA carboxylase beta chain, mitochondrial-like (LOC102043970), mRNA K01969 E6.4.1.4B 3-methylcrotonyl-CoA carboxylase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01969 Q9V9A7 1897 9.9e-211 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Drosophila melanogaster GN=l(2)04524 PE=2 SV=1 PF02935//PF06833//PF00484//PF10186 Cytochrome c oxidase subunit VIIc//Malonate decarboxylase gamma subunit (MdcE)//Carbonic anhydrase//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006123//GO:0006807//GO:0010508//GO:0015992//GO:0006730 mitochondrial electron transport, cytochrome c to oxygen//nitrogen compound metabolic process//positive regulation of autophagy//proton transport//one-carbon metabolic process GO:0016874//GO:0004089//GO:0004129//GO:0008270 ligase activity//carbonate dehydratase activity//cytochrome-c oxidase activity//zinc ion binding GO:0045277 respiratory chain complex IV KOG0540 3-Methylcrotonyl-CoA carboxylase, non-biotin containing subunit/Acetyl-CoA carboxylase carboxyl transferase, subunit beta Cluster-8309.41670 BP_3 1714.67 51.74 1889 189240330 XP_001809949.1 1435 4.9e-156 PREDICTED: probable actin-related protein 2/3 complex subunit 2 [Tribolium castaneum] 533163901 XM_005395664.1 122 1.28794e-54 PREDICTED: Chinchilla lanigera actin related protein 2/3 complex, subunit 2, 34kDa (Arpc2), transcript variant X3, mRNA K05758 ARPC2 actin related protein 2/3 complex, subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05758 Q7PVX8 1305 2.4e-142 Probable actin-related protein 2/3 complex subunit 2 OS=Anopheles gambiae GN=Arc-p34 PE=3 SV=2 PF04045//PF05856 Arp2/3 complex, 34 kD subunit p34-Arc//ARP2/3 complex 20 kDa subunit (ARPC4) GO:0030833//GO:0030041//GO:0034314 regulation of actin filament polymerization//actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0005885//GO:0015629 Arp2/3 protein complex//actin cytoskeleton KOG2826 Actin-related protein Arp2/3 complex, subunit ARPC2 Cluster-8309.41672 BP_3 12.00 8.11 359 -- -- -- -- -- 514833854 KC795683.1 267 5.62625e-136 Scylla paramamosain beta-actin mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41673 BP_3 410.00 9.54 2364 110617755 ABG78596.1 1805 7.7e-199 beta-actin [Mizuhopecten yessoensis] 514833854 KC795683.1 912 0 Scylla paramamosain beta-actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 Q26065 1796 3.5e-199 Actin, adductor muscle OS=Placopecten magellanicus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.41674 BP_3 380.81 4.86 4068 546683519 ERL93321.1 210 1.2e-13 hypothetical protein D910_10615 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus -- -- Cluster-8309.41677 BP_3 1509.86 9.13 8262 91079350 XP_969694.1 3799 0.0e+00 PREDICTED: lysosomal alpha-glucosidase-like [Tribolium castaneum] -- -- -- -- -- K12316 GAA lysosomal alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12316 Q6P7A9 2110 4.7e-235 Lysosomal alpha-glucosidase OS=Rattus norvegicus GN=Gaa PE=2 SV=1 PF01055//PF00096//PF13465//PF13912//PF02892 Glycosyl hydrolases family 31//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BED zinc finger GO:0005975 carbohydrate metabolic process GO:0046872//GO:0004553//GO:0003677 metal ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding -- -- -- -- Cluster-8309.41678 BP_3 5.00 0.38 933 389608135 BAM17679.1 255 1.6e-19 ribosomal protein LP2 [Papilio xuthus]>gi|389610557|dbj|BAM18890.1| ribosomal protein LP2 [Papilio polytes] -- -- -- -- -- K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P05389 221 5.9e-17 60S acidic ribosomal protein P2 OS=Drosophila melanogaster GN=RpLP2 PE=1 SV=1 PF12844//PF13184 Helix-turn-helix domain//NusA-like KH domain -- -- GO:0003723//GO:0043565 RNA binding//sequence-specific DNA binding -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-8309.41680 BP_3 252.04 1.32 9525 815914229 XP_012242394.1 2221 1.8e-246 PREDICTED: uncharacterized protein LOC100740589 isoform X1 [Bombus impatiens] 642918459 XM_008193262.1 304 4.42022e-155 PREDICTED: Tribolium castaneum FH1/FH2 domain-containing protein 3 (LOC659452), transcript variant X5, mRNA -- -- -- -- Q76LL6 1232 3.5e-133 FH1/FH2 domain-containing protein 3 OS=Mus musculus GN=Fhod3 PE=1 SV=1 PF00895//PF01059 ATP synthase protein 8//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0055114//GO:0015992//GO:0006120//GO:0015986 oxidation-reduction process//proton transport//mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG1925 Rac1 GTPase effector FHOS Cluster-8309.41681 BP_3 13.59 0.49 1627 270008756 EFA05204.1 538 4.4e-52 hypothetical protein TcasGA2_TC015340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49327 291 7.9e-25 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF00025//PF00975//PF16093 ADP-ribosylation factor family//Thioesterase domain//Proteasome assembly chaperone 4 GO:0009058//GO:0043248 biosynthetic process//proteasome assembly GO:0005525//GO:0016788 GTP binding//hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.41682 BP_3 35.33 0.63 3007 546684533 ERL94164.1 1157 1.3e-123 hypothetical protein D910_11446, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41683 BP_3 12.72 0.59 1322 749731807 XP_011136864.1 1293 1.0e-139 PREDICTED: eukaryotic translation initiation factor 2 subunit 1 [Harpegnathos saltator]>gi|749731809|ref|XP_011136872.1| PREDICTED: eukaryotic translation initiation factor 2 subunit 1 [Harpegnathos saltator] 820840867 XM_003691501.2 401 0 PREDICTED: Apis florea eukaryotic translation initiation factor 2 subunit 1 (LOC100870691), mRNA K03237 EIF2S1 translation initiation factor 2 subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03237 P41374 1060 4.3e-114 Eukaryotic translation initiation factor 2 subunit 1 OS=Drosophila melanogaster GN=eIF-2alpha PE=2 SV=1 PF00575//PF07541 S1 RNA binding domain//Eukaryotic translation initiation factor 2 alpha subunit GO:0006446 regulation of translational initiation GO:0003723//GO:0003743//GO:0003676 RNA binding//translation initiation factor activity//nucleic acid binding GO:0005850//GO:0005840 eukaryotic translation initiation factor 2 complex//ribosome KOG2916 Translation initiation factor 2, alpha subunit (eIF-2alpha) Cluster-8309.41685 BP_3 413.69 1.29 15775 546679672 ERL90099.1 6770 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 3978 0.0e+00 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF00462//PF13176//PF13414//PF13374//PF00515//PF00018//PF14604//PF02737//PF08141//PF00389//PF03493//PF02826//PF03446//PF13181 Glutaredoxin//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//SH3 domain//Variant SH3 domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Small acid-soluble spore protein H family//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//Tetratricopeptide repeat GO:0006631//GO:0006552//GO:0045454//GO:0008152//GO:0018874//GO:0006633//GO:0006098//GO:0006813//GO:0006568//GO:0019521//GO:0006118//GO:0030436//GO:0006554//GO:0055114//GO:0006574//GO:0006550 fatty acid metabolic process//leucine catabolic process//cell redox homeostasis//metabolic process//benzoate metabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//potassium ion transport//tryptophan metabolic process//D-gluconate metabolic process//obsolete electron transport//asexual sporulation//lysine catabolic process//oxidation-reduction process//valine catabolic process//isoleucine catabolic process GO:0015035//GO:0009055//GO:0016491//GO:0005515//GO:0051287//GO:0003857//GO:0004616//GO:0015269//GO:0016616 protein disulfide oxidoreductase activity//electron carrier activity//oxidoreductase activity//protein binding//NAD binding//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity//calcium-activated potassium channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016020//GO:0042601 membrane//endospore-forming forespore KOG1998 Signaling protein DOCK180 Cluster-8309.41686 BP_3 123.73 1.03 6099 91092316 XP_970010.1 1371 4.2e-148 PREDICTED: beta-1,3-glucan-binding protein [Tribolium castaneum]>gi|270015726|gb|EFA12174.1| Gram-negative bacteria binding protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q76DI2 1247 4.1e-135 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF15886//PF00722 Carbohydrate binding domain (family 32)//Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0030246 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding -- -- -- -- Cluster-8309.41688 BP_3 235.62 4.41 2866 189237332 XP_973384.2 1523 4.7e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 83 9.40622e-33 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.4e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.41689 BP_3 3124.24 38.26 4228 478253821 ENN74113.1 4477 0.0e+00 hypothetical protein YQE_09086, partial [Dendroctonus ponderosae]>gi|546684626|gb|ERL94243.1| hypothetical protein D910_11524 [Dendroctonus ponderosae] 817219709 XM_012430138.1 107 6.34634e-46 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 3293 0.0e+00 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF16656//PF01618//PF00041//PF13895 Purple acid Phosphatase, N-terminal domain//MotA/TolQ/ExbB proton channel family//Fibronectin type III domain//Immunoglobulin domain GO:0006771//GO:0015031//GO:0006810//GO:0019497 riboflavin metabolic process//protein transport//transport//hexachlorocyclohexane metabolic process GO:0003993//GO:0008565//GO:0046872//GO:0005515 acid phosphatase activity//protein transporter activity//metal ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.41690 BP_3 1145.72 15.35 3889 478253821 ENN74113.1 4445 0.0e+00 hypothetical protein YQE_09086, partial [Dendroctonus ponderosae]>gi|546684626|gb|ERL94243.1| hypothetical protein D910_11524 [Dendroctonus ponderosae] 817219709 XM_012430138.1 87 7.65315e-35 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 3261 0.0e+00 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF00041//PF01618//PF13895//PF16656 Fibronectin type III domain//MotA/TolQ/ExbB proton channel family//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0015031//GO:0006771//GO:0019497//GO:0006810 protein transport//riboflavin metabolic process//hexachlorocyclohexane metabolic process//transport GO:0046872//GO:0008565//GO:0003993//GO:0005515 metal ion binding//protein transporter activity//acid phosphatase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.41691 BP_3 13.33 0.55 1454 189238796 XP_974873.2 254 3.3e-19 PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|642927324|ref|XP_008195221.1| PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|270009983|gb|EFA06431.1| hypothetical protein TcasGA2_TC009311 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.41692 BP_3 1065.00 14.93 3730 815792875 XP_012217045.1 986 1.1e-103 PREDICTED: splicing factor U2af 38 kDa subunit-like [Linepithema humile] 642933804 XM_964331.2 254 1.07337e-127 PREDICTED: Tribolium castaneum splicing factor U2af 38 kDa subunit (LOC657904), mRNA K12836 U2AF1 splicing factor U2AF 35 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12836 Q94535 955 1.8e-101 Splicing factor U2af 38 kDa subunit OS=Drosophila melanogaster GN=U2af38 PE=1 SV=2 PF00642//PF02954//PF00076 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Bacterial regulatory protein, Fis family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0043565//GO:0046872 nucleic acid binding//sequence-specific DNA binding//metal ion binding -- -- KOG2202 U2 snRNP splicing factor, small subunit, and related proteins Cluster-8309.41693 BP_3 746.63 3.86 9604 642926098 XP_008194783.1 5696 0.0e+00 PREDICTED: uncharacterized protein KIAA1109 [Tribolium castaneum] 755951836 XM_011303587.1 50 7.02857e-14 PREDICTED: Fopius arisanus uncharacterized protein KIAA1109 (LOC105265834), transcript variant X9, mRNA -- -- -- -- A2AAE1 1928 7.0e-214 Uncharacterized protein KIAA1109 OS=Mus musculus GN=Kiaa1109 PE=1 SV=4 PF08093//PF11815 Magi 5 toxic peptide family//Domain of unknown function (DUF3336) GO:0009405//GO:0006810//GO:0006629//GO:0016042//GO:0046486 pathogenesis//transport//lipid metabolic process//lipid catabolic process//glycerolipid metabolic process GO:0004806//GO:0019871 triglyceride lipase activity//sodium channel inhibitor activity GO:0005576 extracellular region KOG3596 Uncharacterized conserved protein Cluster-8309.41694 BP_3 83.46 0.31 13363 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 221 8.55884e-109 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q96EP0 878 5.5e-92 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens GN=RNF31 PE=1 SV=1 PF00096//PF05495//PF13806//PF07776//PF01426//PF05121//PF13465//PF07975//PF00412//PF00641//PF13912//PF09182//PF02845//PF08273 Zinc finger, C2H2 type//CHY zinc finger//Rieske-like [2Fe-2S] domain//Zinc-finger associated domain (zf-AD)//BAH domain//Gas vesicle protein K//Zinc-finger double domain//TFIIH C1-like domain//LIM domain//Zn-finger in Ran binding protein and others//C2H2-type zinc finger//Bacterial purine repressor, N-terminal//CUE domain//Zinc-binding domain of primase-helicase GO:0006281//GO:0031412//GO:0055114//GO:0006269//GO:0006355//GO:0042128//GO:0006351//GO:0006807 DNA repair//gas vesicle organization//oxidation-reduction process//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//nitrate assimilation//transcription, DNA-templated//nitrogen compound metabolic process GO:0003896//GO:0003682//GO:0008942//GO:0008270//GO:0005515//GO:0003677//GO:0004386//GO:0046872 DNA primase activity//chromatin binding//nitrite reductase [NAD(P)H] activity//zinc ion binding//protein binding//DNA binding//helicase activity//metal ion binding GO:0005730//GO:0005657//GO:0000785//GO:0005634 nucleolus//replication fork//chromatin//nucleus -- -- Cluster-8309.41695 BP_3 268.79 4.00 3528 642938247 XP_008198128.1 619 3.8e-61 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 58 9.16487e-19 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 494 4.9e-48 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF17096//PF02932//PF01080//PF03293//PF07714//PF00069 Altered inheritance of mitochondria protein 3//Neurotransmitter-gated ion-channel transmembrane region//Presenilin//Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0019083//GO:0006811//GO:0006206//GO:0051016//GO:0006144//GO:0006351 protein phosphorylation//viral transcription//ion transport//pyrimidine nucleobase metabolic process//barbed-end actin filament capping//purine nucleobase metabolic process//transcription, DNA-templated GO:0003899//GO:0005524//GO:0004672//GO:0004190//GO:0003677 DNA-directed RNA polymerase activity//ATP binding//protein kinase activity//aspartic-type endopeptidase activity//DNA binding GO:0005730//GO:0030479//GO:0016021//GO:0016020 nucleolus//actin cortical patch//integral component of membrane//membrane KOG0671 LAMMER dual specificity kinases Cluster-8309.41696 BP_3 1832.00 84.00 1343 642920456 XP_975647.2 1257 1.5e-135 PREDICTED: eukaryotic translation initiation factor 3 subunit F-1 [Tribolium castaneum] -- -- -- -- -- K03249 EIF3F translation initiation factor 3 subunit F http://www.genome.jp/dbget-bin/www_bget?ko:K03249 B4JGX4 1127 7.4e-122 Eukaryotic translation initiation factor 3 subunit F-1 OS=Drosophila grimshawi GN=eIF3-S5-1 PE=3 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- KOG2975 Translation initiation factor 3, subunit f (eIF-3f) Cluster-8309.41699 BP_3 424.86 13.25 1837 642928935 XP_008195623.1 1413 1.7e-153 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9VCX1 836 5.6e-88 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF02196//PF00788 Raf-like Ras-binding domain//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- -- -- Cluster-8309.41700 BP_3 23.23 0.65 2024 546672990 ERL84684.1 1214 2.2e-130 hypothetical protein D910_02111 [Dendroctonus ponderosae] 820858830 XM_003696915.2 86 1.42138e-34 PREDICTED: Apis florea pyruvate dehydrogenase E1 component subunit beta, mitochondrial (LOC100863907), mRNA K00162 PDHB, pdhB pyruvate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00162 O44451 1002 3.5e-107 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Caenorhabditis elegans GN=pdhb-1 PE=1 SV=2 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.41701 BP_3 673.00 16.96 2204 91082953 XP_973566.1 1613 1.3e-176 PREDICTED: pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 [Tribolium castaneum]>gi|270007627|gb|EFA04075.1| hypothetical protein TcasGA2_TC014309 [Tribolium castaneum] -- -- -- -- -- K16174 MRPS18B, MRPS18-2 small subunit ribosomal protein S18b, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16174 Q68FS6 1003 2.9e-107 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Rattus norvegicus GN=Pyroxd1 PE=2 SV=1 PF01266//PF05834//PF07992//PF01084//PF00070//PF01593 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Ribosomal protein S18//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase GO:0042254//GO:0055114//GO:0016117//GO:0006412 ribosome biogenesis//oxidation-reduction process//carotenoid biosynthetic process//translation GO:0003735//GO:0016491//GO:0016705 structural constituent of ribosome//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005622//GO:0005840 intracellular//ribosome KOG4021 Mitochondrial ribosomal protein S18b Cluster-8309.41702 BP_3 17.20 0.33 2826 478256708 ENN76890.1 2387 3.0e-266 hypothetical protein YQE_06731, partial [Dendroctonus ponderosae] -- -- -- -- -- K08766 CPT2 carnitine O-palmitoyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08766 Q5U3U3 1611 1.2e-177 Carnitine O-palmitoyltransferase 2, mitochondrial OS=Danio rerio GN=cpt2 PE=2 SV=2 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3719 Carnitine O-acyltransferase CPT2/YAT1 Cluster-8309.41703 BP_3 34.06 1.15 1720 642919151 XP_008191758.1 383 4.3e-34 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04345//PF00041 Chorismate lyase//Fibronectin type III domain GO:0006744 ubiquinone biosynthetic process GO:0005515//GO:0008813 protein binding//chorismate lyase activity GO:0005737 cytoplasm -- -- Cluster-8309.41706 BP_3 21.27 1.98 810 642915291 XP_008190557.1 301 6.6e-25 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 151 6.7e-09 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41708 BP_3 66.56 0.86 4034 642924094 XP_008194003.1 2342 7.0e-261 PREDICTED: lysine--tRNA ligase isoform X1 [Tribolium castaneum] 157106532 XM_001649316.1 207 1.55687e-101 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1951 6.3e-217 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF01336//PF01409//PF17121//PF00152 OB-fold nucleic acid binding domain//tRNA synthetases class II core domain (F)//Zinc finger, C3HC4 type (RING finger)//tRNA synthetases class II (D, K and N) GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0003676//GO:0008270//GO:0000166//GO:0004812//GO:0005524//GO:0000049//GO:0005515 nucleic acid binding//zinc ion binding//nucleotide binding//aminoacyl-tRNA ligase activity//ATP binding//tRNA binding//protein binding GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.41710 BP_3 183.47 3.98 2516 91088037 XP_974425.1 2035 1.7e-225 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 1402 1.8e-153 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF01344//PF07646 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.41711 BP_3 60.92 0.79 3993 91079889 XP_968047.1 3287 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 3.4312e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 1.2e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF00443//PF14560//PF00240 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-like domain//Ubiquitin family GO:0016579 protein deubiquitination GO:0005515//GO:0036459 protein binding//ubiquitinyl hydrolase activity -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.41714 BP_3 72.76 24.89 432 568599616 AHE13803.1 289 8.6e-24 chemosensory protein 8 [Lissorhoptrus oryzophilus] 817185798 XM_012431951.1 64 4.84231e-23 PREDICTED: Orussus abietinus ejaculatory bulb-specific protein 3-like (LOC105703508), mRNA -- -- -- -- Q9W1C9 252 6.9e-21 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41718 BP_3 381.76 18.49 1287 642935880 XP_008198210.1 435 3.0e-40 PREDICTED: uncharacterized protein LOC103314310 [Tribolium castaneum] 642935879 XM_008199988.1 39 1.19904e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103314310 (LOC103314310), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41719 BP_3 578.01 12.42 2534 642923805 XP_008193890.1 1839 9.4e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 5.0e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0003723//GO:0000166 nucleic acid binding//RNA binding//nucleotide binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41720 BP_3 27.57 0.39 3736 642923805 XP_008193890.1 1839 1.4e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 7.3e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41721 BP_3 223.83 2.87 4050 642923805 XP_008193890.1 1839 1.5e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 7.9e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41722 BP_3 188.16 4.70 2222 642923805 XP_008193890.1 1839 8.2e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 4.4e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41725 BP_3 1900.25 14.92 6431 642924727 XP_008194417.1 3076 0.0e+00 PREDICTED: RB1-inducible coiled-coil protein 1 isoform X4 [Tribolium castaneum] 642924726 XM_008196195.1 59 4.66435e-19 PREDICTED: Tribolium castaneum RB1-inducible coiled-coil protein 1 (LOC663996), transcript variant X7, mRNA K17589 RB1CC1 RB1-inducible coiled-coil protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17589 Q9HC24 552 1.7e-54 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 PF11057 Cortexin of kidney -- -- -- -- GO:0031224 intrinsic component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.41728 BP_3 73.36 0.43 8427 270006717 EFA03165.1 2578 6.3e-288 hypothetical protein TcasGA2_TC013085 [Tribolium castaneum] 642924726 XM_008196195.1 59 6.12042e-19 PREDICTED: Tribolium castaneum RB1-inducible coiled-coil protein 1 (LOC663996), transcript variant X7, mRNA K17589 RB1CC1 RB1-inducible coiled-coil protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17589 Q9HC24 552 2.2e-54 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 PF11057//PF04310 Cortexin of kidney//MukB N-terminal GO:0030261//GO:0007059 chromosome condensation//chromosome segregation GO:0003677//GO:0005524 DNA binding//ATP binding GO:0031224//GO:0009295 intrinsic component of membrane//nucleoid KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.41729 BP_3 96.55 0.86 5702 189238721 XP_970605.2 2529 2.1e-282 PREDICTED: collagen type IV alpha-3-binding protein isoform X1 [Tribolium castaneum]>gi|270010089|gb|EFA06537.1| hypothetical protein TcasGA2_TC009441 [Tribolium castaneum] -- -- -- -- -- K08283 COL4A3BP collagen type IV alpha-3-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08283 Q6VVX2 1509 1.6e-165 Collagen type IV alpha-3-binding protein OS=Cricetulus griseus GN=COL4A3BP PE=1 SV=1 PF08926//PF01852 Domain of unknown function (DUF1908)//START domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0000287//GO:0004674//GO:0005524//GO:0008289//GO:0005543 magnesium ion binding//protein serine/threonine kinase activity//ATP binding//lipid binding//phospholipid binding -- -- KOG1737 Oxysterol-binding protein Cluster-8309.41731 BP_3 65.79 0.62 5378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01635//PF03014 Coronavirus M matrix/glycoprotein//Structural protein 2 GO:0019058 viral life cycle GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.41733 BP_3 288.05 3.74 4003 237681143 NP_001153714.1 3081 0.0e+00 poly-(ADP-ribose) polymerase [Tribolium castaneum] 505789579 XM_004605427.1 81 1.70563e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 2398 9.2e-269 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00645//PF02877//PF00644//PF08063 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Poly(ADP-ribose) polymerase, regulatory domain//Poly(ADP-ribose) polymerase catalytic domain//PADR1 (NUC008) domain GO:0006471 protein ADP-ribosylation GO:0003677//GO:0008270//GO:0003950 DNA binding//zinc ion binding//NAD+ ADP-ribosyltransferase activity GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.41735 BP_3 220.09 1.85 6018 237681143 NP_001153714.1 3231 0.0e+00 poly-(ADP-ribose) polymerase [Tribolium castaneum] 505789579 XM_004605427.1 81 2.57199e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 2522 5.8e-283 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00645//PF00644//PF02877//PF08063 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Poly(ADP-ribose) polymerase catalytic domain//Poly(ADP-ribose) polymerase, regulatory domain//PADR1 (NUC008) domain GO:0006471 protein ADP-ribosylation GO:0003950//GO:0003677//GO:0008270 NAD+ ADP-ribosyltransferase activity//DNA binding//zinc ion binding GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.41736 BP_3 679.76 10.55 3398 270004713 EFA01161.1 1361 3.4e-147 hypothetical protein TcasGA2_TC010386 [Tribolium castaneum] 828210619 XM_004208630.2 127 3.87937e-57 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 1213 2.0e-131 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF07714//PF06293//PF00069//PF09573 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//TaqI restriction endonuclease GO:0006308//GO:0009307//GO:0006468 DNA catabolic process//DNA restriction-modification system//protein phosphorylation GO:0004672//GO:0016773//GO:0009036//GO:0003677//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//Type II site-specific deoxyribonuclease activity//DNA binding//ATP binding GO:0016020//GO:0009359 membrane//Type II site-specific deoxyribonuclease complex KOG4717 Serine/threonine protein kinase Cluster-8309.41738 BP_3 263.69 15.31 1122 189237587 XP_975066.2 639 5.8e-64 PREDICTED: nuclear cap-binding protein subunit 2 [Tribolium castaneum] 755860540 XM_005178495.2 59 7.94432e-20 PREDICTED: Musca domestica nuclear cap-binding protein subunit 2B (LOC101888112), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 577 3.7e-58 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.41739 BP_3 330.17 3.85 4427 189237587 XP_975066.2 695 7.4e-70 PREDICTED: nuclear cap-binding protein subunit 2 [Tribolium castaneum] 755860540 XM_005178495.2 76 1.13624e-28 PREDICTED: Musca domestica nuclear cap-binding protein subunit 2B (LOC101888112), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 629 1.4e-63 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.41740 BP_3 415.10 4.04 5244 642924396 XP_008194278.1 1678 9.1e-184 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] -- -- -- -- -- K02178 BUB1 checkpoint serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02178 O43683 451 7.1e-43 Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens GN=BUB1 PE=1 SV=1 PF07714//PF00541//PF00069//PF03852 Protein tyrosine kinase//Adenoviral fibre protein (knob domain)//Protein kinase domain//DNA mismatch endonuclease Vsr GO:0006298//GO:0019062//GO:0006468 mismatch repair//virion attachment to host cell//protein phosphorylation GO:0005524//GO:0004519//GO:0004672 ATP binding//endonuclease activity//protein kinase activity GO:0019028 viral capsid KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.41741 BP_3 99.22 0.63 7851 642924396 XP_008194278.1 1678 1.4e-183 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] 706147644 XM_010207329.1 63 3.40647e-21 PREDICTED: Colius striatus family with sequence similarity 76, member B (FAM76B), partial mRNA -- -- -- -- Q5ZJ65 773 4.9e-80 Protein FAM76A OS=Gallus gallus GN=FAM76A PE=2 SV=1 PF04513//PF01025//PF00416//PF03938//PF04728//PF00170//PF03852//PF01920//PF07714//PF08656//PF00069//PF00541 Baculovirus polyhedron envelope protein, PEP, C terminus//GrpE//Ribosomal protein S13/S18//Outer membrane protein (OmpH-like)//Lipoprotein leucine-zipper//bZIP transcription factor//DNA mismatch endonuclease Vsr//Prefoldin subunit//Protein tyrosine kinase//DASH complex subunit Dad3//Protein kinase domain//Adenoviral fibre protein (knob domain) GO:0006457//GO:0006298//GO:0019062//GO:0006412//GO:0006355//GO:0008608//GO:0042254//GO:0006468 protein folding//mismatch repair//virion attachment to host cell//translation//regulation of transcription, DNA-templated//attachment of spindle microtubules to kinetochore//ribosome biogenesis//protein phosphorylation GO:0042803//GO:0004672//GO:0004519//GO:0003723//GO:0000774//GO:0051082//GO:0051087//GO:0003735//GO:0043565//GO:0003700//GO:0005524//GO:0005198 protein homodimerization activity//protein kinase activity//endonuclease activity//RNA binding//adenyl-nucleotide exchange factor activity//unfolded protein binding//chaperone binding//structural constituent of ribosome//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//ATP binding//structural molecule activity GO:0019867//GO:0072686//GO:0019031//GO:0005667//GO:0005622//GO:0042729//GO:0005840//GO:0016272//GO:0019028 outer membrane//mitotic spindle//viral envelope//transcription factor complex//intracellular//DASH complex//ribosome//prefoldin complex//viral capsid KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.41742 BP_3 21.75 0.35 3284 546675278 ERL86514.1 1453 7.0e-158 hypothetical protein D910_03918 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96T76 555 3.9e-55 MMS19 nucleotide excision repair protein homolog OS=Homo sapiens GN=MMS19 PE=1 SV=2 PF02985//PF17082//PF03274 HEAT repeat//Spindle Pole Component 29//Foamy virus BEL 1/2 protein GO:0030474//GO:0016032//GO:0045893 spindle pole body duplication//viral process//positive regulation of transcription, DNA-templated GO:0005515//GO:0005200 protein binding//structural constituent of cytoskeleton GO:0005856//GO:0005823 cytoskeleton//central plaque of spindle pole body KOG1967 DNA repair/transcription protein Mms19 Cluster-8309.41743 BP_3 509.81 9.10 2992 642917967 XP_008198963.1 3830 0.0e+00 PREDICTED: pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Tribolium castaneum]>gi|270004690|gb|EFA01138.1| hypothetical protein TcasGA2_TC010363 [Tribolium castaneum] 766925232 XM_011496200.1 153 1.20101e-71 PREDICTED: Ceratosolen solmsi marchali pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (LOC105359580), transcript variant X2, mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 1847 5.4e-205 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF12831//PF00070//PF01266//PF07992 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0006563//GO:0006566//GO:0006546//GO:0006544//GO:0055114 L-serine metabolic process//threonine metabolic process//glycine catabolic process//glycine metabolic process//oxidation-reduction process GO:0016491//GO:0004047 oxidoreductase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.41746 BP_3 7.39 0.58 904 642926173 XP_008194815.1 802 5.9e-83 PREDICTED: vinculin isoform X5 [Tribolium castaneum] -- -- -- -- -- K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 697 3.6e-72 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044 Vinculin family GO:0007155 cell adhesion GO:0051015 actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.41747 BP_3 441.35 4.19 5373 642937954 XP_008199143.1 2954 0.0e+00 PREDICTED: isoleucine--tRNA ligase, mitochondrial [Tribolium castaneum] 571578376 XM_006572314.1 45 2.36053e-11 PREDICTED: Apis mellifera isoleucyl-tRNA synthetase, mitochondrial-like (LOC726483), partial mRNA K01870 IARS, ileS isoleucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01870 Q9NSE4 1916 9.6e-213 Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens GN=IARS2 PE=1 SV=2 PF10473//PF08264//PF00133//PF09334 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Anticodon-binding domain of tRNA//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0006418 tRNA aminoacylation for protein translation GO:0045502//GO:0008134//GO:0005524//GO:0004812//GO:0000166//GO:0042803 dynein binding//transcription factor binding//ATP binding//aminoacyl-tRNA ligase activity//nucleotide binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex KOG0433 Isoleucyl-tRNA synthetase Cluster-8309.41749 BP_3 1030.41 12.07 4408 91093203 XP_969368.1 999 4.1e-105 PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|642938151|ref|XP_008199786.1| PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|270016483|gb|EFA12929.1| hypothetical protein TcasGA2_TC010475 [Tribolium castaneum] 170043832 XM_001849523.1 373 0 Culex quinquefasciatus hippocalcin, mRNA -- -- -- -- P42325 984 9.3e-105 Neurocalcin homolog OS=Drosophila melanogaster GN=Nca PE=1 SV=2 PF13499//PF02745//PF13833//PF10591//PF13405//PF11095//PF12763//PF00036//PF13202 EF-hand domain pair//Methyl-coenzyme M reductase alpha subunit, N-terminal domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Gem-associated protein 7 (Gemin7)//Cytoskeletal-regulatory complex EF hand//EF hand//EF hand GO:0046656//GO:0007165//GO:0015948 folic acid biosynthetic process//signal transduction//methanogenesis GO:0005515//GO:0050524//GO:0005509 protein binding//coenzyme-B sulfoethylthiotransferase activity//calcium ion binding GO:0032797//GO:0005578 SMN complex//proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.41750 BP_3 367.94 2.11 8696 478262858 ENN81340.1 3676 0.0e+00 hypothetical protein YQE_02251, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VFB7 1853 3.2e-205 Trafficking protein particle complex subunit 10 OS=Drosophila melanogaster GN=SIDL PE=1 SV=1 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG1931 Putative transmembrane protein Cluster-8309.41752 BP_3 3.00 2.89 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41753 BP_3 1134.11 44.00 1534 478254694 ENN74935.1 403 1.9e-36 hypothetical protein YQE_08513, partial [Dendroctonus ponderosae] 768418772 XM_011551784.1 53 2.36851e-16 PREDICTED: Plutella xylostella uncharacterized LOC105381973 (LOC105381973), mRNA -- -- -- -- -- -- -- -- PF06936 Selenoprotein S (SelS) GO:0006886 intracellular protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.41755 BP_3 33.31 0.56 3184 478251864 ENN72303.1 1127 4.3e-120 hypothetical protein YQE_11046, partial [Dendroctonus ponderosae]>gi|546674377|gb|ERL85764.1| hypothetical protein D910_03179 [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 2.1e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.41756 BP_3 1233.62 7.20 8552 642935792 XP_008198176.1 4758 0.0e+00 PREDICTED: nitric oxide synthase, salivary gland isoform X2 [Tribolium castaneum] 148367285 AB304919.1 233 1.16718e-115 Luciola lateralis LlNOS mRNA for nitric oxide synthase, complete cds K13240 NOS1 nitric-oxide synthase, brain http://www.genome.jp/dbget-bin/www_bget?ko:K13240 B1B557 3625 0.0e+00 Nitric oxide synthase-like protein OS=Bombyx mori GN=NSL PE=2 SV=1 PF10505//PF00667//PF04103//PF02898//PF00802//PF00175//PF01040//PF00258//PF09570//PF00335//PF01384 NMDA receptor-regulated gene protein 2 C-terminus//FAD binding domain//CD20-like family//Nitric oxide synthase, oxygenase domain//Pneumovirus attachment glycoprotein G//Oxidoreductase NAD-binding domain//UbiA prenyltransferase family//Flavodoxin//SinI restriction endonuclease//Tetraspanin family//Phosphate transporter family GO:0006308//GO:0009307//GO:0055114//GO:0006817//GO:0006809 DNA catabolic process//DNA restriction-modification system//oxidation-reduction process//phosphate ion transport//nitric oxide biosynthetic process GO:0003677//GO:0009036//GO:0016491//GO:0005315//GO:0010181//GO:0004517//GO:0004659 DNA binding//Type II site-specific deoxyribonuclease activity//oxidoreductase activity//inorganic phosphate transmembrane transporter activity//FMN binding//nitric-oxide synthase activity//prenyltransferase activity GO:0009359//GO:0016020//GO:0008023//GO:0016021//GO:0055036 Type II site-specific deoxyribonuclease complex//membrane//transcription elongation factor complex//integral component of membrane//virion membrane KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.41757 BP_3 578.28 4.83 6062 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.0e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF01279//PF01331//PF09266//PF00023//PF13606 Parathyroid hormone family//mRNA capping enzyme, catalytic domain//Viral DNA topoisomerase I, N-terminal//Ankyrin repeat//Ankyrin repeat GO:0007165//GO:0006397//GO:0006370//GO:0006265 signal transduction//mRNA processing//7-methylguanosine mRNA capping//DNA topological change GO:0003677//GO:0003916//GO:0005179//GO:0004484//GO:0005515 DNA binding//DNA topoisomerase activity//hormone activity//mRNA guanylyltransferase activity//protein binding GO:0005576 extracellular region -- -- Cluster-8309.41762 BP_3 252.42 1.22 10235 642911353 XP_008199386.1 6855 0.0e+00 PREDICTED: uncharacterized protein LOC659886 isoform X3 [Tribolium castaneum] 642911358 XM_008201167.1 137 3.24768e-62 PREDICTED: Tribolium castaneum uncharacterized LOC659886 (LOC659886), transcript variant X6, mRNA -- -- -- -- B6RSP1 355 1.9e-31 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41763 BP_3 136.44 0.89 7662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41764 BP_3 520.00 29.41 1144 765141696 XP_011482082.1 415 5.6e-38 PREDICTED: polyubiquitin-C [Oryzias latipes] 568815687 NM_001288669.1 98 1.69344e-41 Solanum tuberosum ubiquitin-40S ribosomal protein S27a-like (LOC102593024), mRNA >gnl|BL_ORD_ID|2726171 Solanum tuberosum clone 068E12 ubiquitin extension protein-like protein mRNA, complete cds K04551 UBB ubiquitin B http://www.genome.jp/dbget-bin/www_bget?ko:K04551 P0CG54 412 5.1e-39 Polyubiquitin-B OS=Cavia porcellus GN=UBB PE=2 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.41766 BP_3 5.00 0.90 559 861633328 KMQ90923.1 292 5.0e-24 transposable element tc3 transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41767 BP_3 146.77 4.26 1951 642925227 XP_008194475.1 739 2.6e-75 PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum]>gi|642925229|ref|XP_008194476.1| PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HA38 178 1.2e-11 Zinc finger matrin-type protein 3 OS=Homo sapiens GN=ZMAT3 PE=1 SV=1 PF06220//PF12753//PF04988 U1 zinc finger//Nuclear pore complex subunit Nro1//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0003677//GO:0008270//GO:0005515 DNA binding//zinc ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.41768 BP_3 10.20 0.34 1752 642925227 XP_008194475.1 669 3.0e-67 PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum]>gi|642925229|ref|XP_008194476.1| PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HA38 167 2.0e-10 Zinc finger matrin-type protein 3 OS=Homo sapiens GN=ZMAT3 PE=1 SV=1 PF07535//PF06220//PF00096//PF04988//PF05373 DBF zinc finger//U1 zinc finger//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//L-proline 3-hydroxylase, C-terminal GO:0055114 oxidation-reduction process GO:0016706//GO:0008270//GO:0003677//GO:0003676//GO:0046872 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//zinc ion binding//DNA binding//nucleic acid binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.41769 BP_3 761.21 15.90 2599 91086813 XP_973672.1 1182 1.5e-126 PREDICTED: neutral and basic amino acid transport protein rBAT [Tribolium castaneum]>gi|270010450|gb|EFA06898.1| hypothetical protein TcasGA2_TC009845 [Tribolium castaneum] -- -- -- -- -- K06519 SLC3A2, MDU1 solute carrier family 3, member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06519 O16098 254 2.4e-20 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128//PF00763 Alpha amylase, catalytic domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0009396//GO:0046487//GO:0005975//GO:0055114 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//carbohydrate metabolic process//oxidation-reduction process GO:0043169//GO:0003824//GO:0004488 cation binding//catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG0471 Alpha-amylase Cluster-8309.41772 BP_3 20.81 0.96 1332 91079320 XP_967967.1 641 4.1e-64 PREDICTED: probable DNA-3-methyladenine glycosylase [Tribolium castaneum]>gi|270004337|gb|EFA00785.1| hypothetical protein TcasGA2_TC003671 [Tribolium castaneum] -- -- -- -- -- K03652 MPG DNA-3-methyladenine glycosylase http://www.genome.jp/dbget-bin/www_bget?ko:K03652 Q04841 455 6.2e-44 DNA-3-methyladenine glycosylase OS=Mus musculus GN=Mpg PE=2 SV=3 PF02245 Methylpurine-DNA glycosylase (MPG) GO:0006284 base-excision repair GO:0003677//GO:0003905 DNA binding//alkylbase DNA N-glycosylase activity -- -- -- -- Cluster-8309.41773 BP_3 62.71 1.02 3247 91079026 XP_974912.1 554 1.2e-53 PREDICTED: rap1 GTPase-GDP dissociation stimulator 1-B [Tribolium castaneum]>gi|270003670|gb|EFA00118.1| hypothetical protein TcasGA2_TC002934 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52306 138 8.6e-07 Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens GN=RAP1GDS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41775 BP_3 425.21 4.30 5058 642934662 XP_008197757.1 4285 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X4 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.02614e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 659 5.2e-67 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF08727 PDZ domain (Also known as DHR or GLGF)//Poliovirus 3A protein like GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0003968//GO:0004197//GO:0017111//GO:0005515 RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//protein binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.41778 BP_3 9.00 0.65 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41780 BP_3 470.97 22.74 1290 189235252 XP_971328.2 926 3.5e-97 PREDICTED: ubiquitin-conjugating enzyme E2-22 kDa [Tribolium castaneum]>gi|270004126|gb|EFA00574.1| hypothetical protein TcasGA2_TC003444 [Tribolium castaneum] 642916082 XM_966235.3 191 3.83301e-93 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2-22 kDa (LOC659971), mRNA K04649 HIP2, UBC1 ubiquitin-conjugating enzyme (huntingtin interacting protein 2) http://www.genome.jp/dbget-bin/www_bget?ko:K04649 P52486 799 7.7e-84 Ubiquitin-conjugating enzyme E2-22 kDa OS=Drosophila melanogaster GN=UbcD4 PE=1 SV=2 PF02845//PF05773//PF15461//PF05743 CUE domain//RWD domain//Beta-carotene 15,15'-dioxygenase//UEV domain GO:0006464//GO:0015031//GO:0055114 cellular protein modification process//protein transport//oxidation-reduction process GO:0016881//GO:0005515//GO:0016702 acid-amino acid ligase activity//protein binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen -- -- KOG0418 Ubiquitin-protein ligase Cluster-8309.41782 BP_3 40.09 1.11 2030 270004122 EFA00570.1 324 3.5e-27 hypothetical protein TcasGA2_TC003440 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.41783 BP_3 218.63 2.29 4890 357619286 EHJ71921.1 431 3.3e-39 hypothetical protein KGM_05158 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.41785 BP_3 90.74 1.26 3750 478255274 ENN75503.1 1875 9.3e-207 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.41786 BP_3 813.36 6.79 6069 642931864 XP_008196760.1 1314 1.7e-141 PREDICTED: myosin heavy chain, clone 203 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01465//PF04048//PF05929//PF04508 GRIP domain//Sec8 exocyst complex component specific domain//Phage capsid scaffolding protein (GPO) serine peptidase//Viral A-type inclusion protein repeat GO:0016032//GO:0015031//GO:0000042//GO:0006904//GO:0019069 viral process//protein transport//protein targeting to Golgi//vesicle docking involved in exocytosis//viral capsid assembly GO:0005515 protein binding GO:0000145 exocyst -- -- Cluster-8309.41787 BP_3 230.03 3.47 3483 642932705 XP_008196952.1 2372 2.0e-264 PREDICTED: HEAT repeat-containing protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R5R2 1236 4.4e-134 HEAT repeat-containing protein 6 OS=Pongo abelii GN=HEATR6 PE=2 SV=1 PF02985//PF01106//PF00514//PF01667 HEAT repeat//NifU-like domain//Armadillo/beta-catenin-like repeat//Ribosomal protein S27 GO:0042254//GO:0006412//GO:0016226 ribosome biogenesis//translation//iron-sulfur cluster assembly GO:0005506//GO:0003735//GO:0051536//GO:0005515 iron ion binding//structural constituent of ribosome//iron-sulfur cluster binding//protein binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.41789 BP_3 314.00 40.33 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41790 BP_3 121.03 0.87 7024 642915800 XP_008200083.1 1943 2.3e-214 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum] -- -- -- -- -- K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q62371 723 2.7e-74 Discoidin domain-containing receptor 2 OS=Mus musculus GN=Ddr2 PE=1 SV=2 PF00069//PF07714//PF09472 Protein kinase domain//Protein tyrosine kinase//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) GO:0006468//GO:0046656//GO:0015948 protein phosphorylation//folic acid biosynthetic process//methanogenesis GO:0004672//GO:0005524//GO:0030269 protein kinase activity//ATP binding//tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.41792 BP_3 3.00 5.79 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41793 BP_3 102.00 5.09 1258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41794 BP_3 15.15 1.26 870 189240524 XP_971875.2 163 7.1e-09 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16797 143 6.1e-08 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.41797 BP_3 53.40 1.45 2067 642927021 XP_008195106.1 1235 8.3e-133 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X1 [Tribolium castaneum]>gi|642927023|ref|XP_008195107.1| PREDICTED: CREB-regulated transcription coactivator 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K15309 CRTC1, TORC1 CREB-regulated transcription coactivator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15309 Q68ED7 272 1.6e-22 CREB-regulated transcription coactivator 1 OS=Mus musculus GN=Crtc1 PE=1 SV=1 PF00170//PF12884//PF05145 bZIP transcription factor//Transducer of regulated CREB activity, N terminus//Putative ammonia monooxygenase GO:0010468//GO:0051289//GO:0006355 regulation of gene expression//protein homotetramerization//regulation of transcription, DNA-templated GO:0008140//GO:0003700//GO:0043565 cAMP response element binding protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-8309.41798 BP_3 13.65 0.33 2256 642927029 XP_008195110.1 1077 1.9e-114 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U182 182 4.7e-12 CREB-regulated transcription coactivator 2 OS=Mus musculus GN=Crtc2 PE=1 SV=2 PF12884//PF00170 Transducer of regulated CREB activity, N terminus//bZIP transcription factor GO:0006355//GO:0051289 regulation of transcription, DNA-templated//protein homotetramerization GO:0003700//GO:0008140//GO:0043565 transcription factor activity, sequence-specific DNA binding//cAMP response element binding protein binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.41799 BP_3 81.15 1.15 3695 642911809 XP_008200752.1 3666 0.0e+00 PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911811|ref|XP_008200753.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911813|ref|XP_008200754.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 1444 3.6e-158 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41800 BP_3 798.72 4.15 9564 91082921 XP_972710.1 2880 0.0e+00 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] 462337062 APGK01037684.1 46 1.17121e-11 Dendroctonus ponderosae Seq01037694, whole genome shotgun sequence K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 2336 3.4e-261 Annulin OS=Schistocerca americana PE=2 SV=1 PF02417//PF00868//PF01347//PF00927//PF02150 Chromate transporter//Transglutaminase family//Lipoprotein amino terminal region//Transglutaminase family, C-terminal ig like domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0018149//GO:0006869//GO:0006144//GO:0006351//GO:0015703 pyrimidine nucleobase metabolic process//peptide cross-linking//lipid transport//purine nucleobase metabolic process//transcription, DNA-templated//chromate transport GO:0046872//GO:0003810//GO:0015109//GO:0005319//GO:0003899//GO:0003677 metal ion binding//protein-glutamine gamma-glutamyltransferase activity//chromate transmembrane transporter activity//lipid transporter activity//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.41801 BP_3 32.75 7.10 514 91082921 XP_972710.1 555 1.5e-54 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] -- -- -- -- -- K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 501 1.1e-49 Annulin OS=Schistocerca americana PE=2 SV=1 PF00927 Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.41802 BP_3 220.23 1.26 8696 91093513 XP_969441.1 4135 0.0e+00 PREDICTED: RNA polymerase-associated protein CTR9 homolog [Tribolium castaneum]>gi|270002675|gb|EEZ99122.1| hypothetical protein TcasGA2_TC005228 [Tribolium castaneum] 759065906 XM_011344092.1 652 0 PREDICTED: Cerapachys biroi RNA polymerase-associated protein CTR9 homolog (LOC105282240), mRNA K15176 CTR9 RNA polymerase-associated protein CTR9 http://www.genome.jp/dbget-bin/www_bget?ko:K15176 Q4QR29 3306 0.0e+00 RNA polymerase-associated protein CTR9 homolog OS=Xenopus laevis GN=ctr9 PE=2 SV=1 PF07721//PF13181//PF10579//PF13174//PF05009//PF00515//PF13374//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0016032//GO:0007268 viral process//synaptic transmission GO:0042802//GO:0033130//GO:0005515//GO:0043495 identical protein binding//acetylcholine receptor binding//protein binding//protein anchor GO:0042025 host cell nucleus KOG2002 TPR-containing nuclear phosphoprotein that regulates K(+) uptake Cluster-8309.41805 BP_3 787.90 10.17 4026 642921414 XP_008192856.1 2698 3.7e-302 PREDICTED: N-acetylgalactosaminyltransferase 7 [Tribolium castaneum]>gi|270006291|gb|EFA02739.1| hypothetical protein TcasGA2_TC008465 [Tribolium castaneum] 195447413 XM_002071167.1 186 7.33191e-90 Drosophila willistoni GK25256 (Dwil\GK25256), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MV48 2294 1.1e-256 N-acetylgalactosaminyltransferase 7 OS=Drosophila melanogaster GN=GalNAc-T2 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.41807 BP_3 126.24 0.75 8352 642914685 XP_008190314.1 7352 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum] 695158202 XM_009508869.1 44 1.32232e-10 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 Q78DX7 2252 1.6e-251 Proto-oncogene tyrosine-protein kinase ROS OS=Mus musculus GN=Ros1 PE=1 SV=1 PF07714//PF00069//PF00041//PF16656 Protein tyrosine kinase//Protein kinase domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006468//GO:0019497//GO:0006771 protein phosphorylation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005524//GO:0005515//GO:0003993//GO:0046872//GO:0004672 ATP binding//protein binding//acid phosphatase activity//metal ion binding//protein kinase activity -- -- -- -- Cluster-8309.41812 BP_3 44.40 1.05 2338 642930006 XP_008196062.1 318 2.0e-26 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 7.1e-19 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.41813 BP_3 140.62 9.58 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41814 BP_3 1681.07 36.41 2517 826443936 XP_012530879.1 647 1.5e-64 PREDICTED: S-phase kinase-associated protein 1 [Monomorium pharaonis] 831287439 XM_012819624.1 139 6.11418e-64 PREDICTED: Clupea harengus S-phase kinase-associated protein 1 (skp1), mRNA K03094 SKP1, CBF3D S-phase kinase-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03094 Q71U00 564 2.7e-56 S-phase kinase-associated protein 1 OS=Xenopus laevis GN=skp1 PE=1 SV=3 PF00651//PF01466//PF03931 BTB/POZ domain//Skp1 family, dimerisation domain//Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- KOG1724 SCF ubiquitin ligase, Skp1 component Cluster-8309.41815 BP_3 30.49 0.90 1920 546686114 ERL95506.1 352 1.9e-30 hypothetical protein D910_12768 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5EB30 165 3.8e-10 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41817 BP_3 962.53 17.31 2972 91089951 XP_973444.1 2134 6.8e-237 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013551|gb|EFA09999.1| hypothetical protein TcasGA2_TC012169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q55EH8 694 2.7e-71 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF00931//PF13304//PF00006//PF01637//PF01061//PF03193//PF00005 NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//ABC-2 type transporter//Protein of unknown function, DUF258//ABC transporter -- -- GO:0043531//GO:0003924//GO:0005524//GO:0005525//GO:0000166//GO:0016887 ADP binding//GTPase activity//ATP binding//GTP binding//nucleotide binding//ATPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.41818 BP_3 119.37 2.68 2435 478252139 ENN72569.1 550 2.6e-53 hypothetical protein YQE_10794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TXI4 140 3.8e-07 DNA double-strand break repair Rad50 ATPase OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) GN=rad50 PE=3 SV=1 PF09730//PF06315//PF04111//PF06009//PF00769//PF05557//PF02050//PF06160//PF07926 Microtubule-associated protein Bicaudal-D//Isocitrate dehydrogenase kinase/phosphatase (AceK)//Autophagy protein Apg6//Laminin Domain II//Ezrin/radixin/moesin family//Mitotic checkpoint protein//Flagellar FliJ protein//Septation ring formation regulator, EzrA//TPR/MLP1/MLP2-like protein GO:0007094//GO:0007155//GO:0006935//GO:0006006//GO:0000921//GO:0071973//GO:0006606//GO:0006810//GO:0006914 mitotic spindle assembly checkpoint//cell adhesion//chemotaxis//glucose metabolic process//septin ring assembly//bacterial-type flagellum-dependent cell motility//protein import into nucleus//transport//autophagy GO:0008772//GO:0003774//GO:0008092//GO:0016791 [isocitrate dehydrogenase (NADP+)] kinase activity//motor activity//cytoskeletal protein binding//phosphatase activity GO:0016020//GO:0009288//GO:0005737//GO:0019898//GO:0016021//GO:0005940//GO:0005794 membrane//bacterial-type flagellum//cytoplasm//extrinsic component of membrane//integral component of membrane//septin ring//Golgi apparatus -- -- Cluster-8309.41819 BP_3 177.00 5.60 1814 71738525 AAZ40333.1 180 1.6e-10 NFkB [Carcinoscorpius rotundicauda] -- -- -- -- -- K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 157 3.0e-09 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.41821 BP_3 4426.02 25.68 8599 86515360 NP_001034507.1 1560 7.2e-170 dorsal [Tribolium castaneum]>gi|11496169|gb|AAG22858.1| Dorsal [Tribolium castaneum] 462460645 APGK01006274.1 58 2.24642e-18 Dendroctonus ponderosae Seq01006279, whole genome shotgun sequence K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 1100 6.4e-118 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF00554//PF01408//PF10415//PF02894//PF08050 Rel homology DNA-binding domain//Oxidoreductase family, NAD-binding Rossmann fold//Fumarase C C-terminus//Oxidoreductase family, C-terminal alpha/beta domain//Tetracycline resistance leader peptide GO:0006099//GO:0006355//GO:0046677//GO:0055114//GO:0008152 tricarboxylic acid cycle//regulation of transcription, DNA-templated//response to antibiotic//oxidation-reduction process//metabolic process GO:0016829//GO:0003700//GO:0003677//GO:0016491 lyase activity//transcription factor activity, sequence-specific DNA binding//DNA binding//oxidoreductase activity GO:0005667 transcription factor complex -- -- Cluster-8309.41823 BP_3 406.40 17.44 1415 91092922 XP_975933.1 1026 9.8e-109 PREDICTED: uncharacterized protein LOC660277 [Tribolium castaneum]>gi|270003110|gb|EEZ99557.1| hypothetical protein TcasGA2_TC000139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41825 BP_3 686.23 3.06 11087 270014822 EFA11270.1 5203 0.0e+00 hypothetical protein TcasGA2_TC010805 [Tribolium castaneum] 755977937 XM_011310121.1 322 5.07559e-165 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4044 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF04689//PF08074//PF03808//PF00640//PF01874//PF00176 DNA binding protein S1FA//CHDCT2 (NUC038) domain//Glycosyl transferase WecB/TagA/CpsF family//Phosphotyrosine interaction domain (PTB/PID)//ATP:dephospho-CoA triphosphoribosyl transferase//SNF2 family N-terminal domain GO:0016310//GO:0006355//GO:0009058 phosphorylation//regulation of transcription, DNA-templated//biosynthetic process GO:0003677//GO:0005524//GO:0046917//GO:0005515//GO:0008270//GO:0016818 DNA binding//ATP binding//triphosphoribosyl-dephospho-CoA synthase activity//protein binding//zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.41826 BP_3 24.48 0.70 1982 478252048 ENN72479.1 607 5.3e-60 hypothetical protein YQE_10821, partial [Dendroctonus ponderosae] 241594857 XM_002404356.1 105 3.81416e-45 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q91ZQ0 426 2.1e-40 Vacuole membrane protein 1 OS=Rattus norvegicus GN=Vmp1 PE=1 SV=1 PF01741//PF00323 Large-conductance mechanosensitive channel, MscL//Mammalian defensin GO:0006810//GO:0006811//GO:0006952 transport//ion transport//defense response GO:0005216 ion channel activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.41827 BP_3 9.00 1.98 511 91091030 XP_975173.1 350 8.6e-31 PREDICTED: retinol dehydrogenase 12-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 259 1.3e-21 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF01073//PF00106//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0008207//GO:0008209//GO:0055114//GO:0006694 metabolic process//estrogen metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0003824//GO:0050662//GO:0003854//GO:0016616//GO:0016491 catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.4183 BP_3 2.00 1.20 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41831 BP_3 135.74 5.24 1540 189236448 XP_973457.2 1720 3.6e-189 PREDICTED: protein tumorous imaginal discs, mitochondrial isoform X2 [Tribolium castaneum]>gi|270005934|gb|EFA02382.1| hypothetical protein TcasGA2_TC008059 [Tribolium castaneum] 642919851 XM_968364.3 179 2.15375e-86 PREDICTED: Tribolium castaneum protein tumorous imaginal discs, mitochondrial (LOC662253), transcript variant X2, mRNA K09504 DNAJA3 DnaJ homolog subfamily A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09504 Q24331 1392 1.6e-152 Protein tumorous imaginal discs, mitochondrial OS=Drosophila virilis GN=l(2)tid PE=2 SV=1 PF00684 DnaJ central domain GO:0006260//GO:0009408//GO:0006457 DNA replication//response to heat//protein folding GO:0046872//GO:0051082//GO:0031072//GO:0005524 metal ion binding//unfolded protein binding//heat shock protein binding//ATP binding GO:0005737 cytoplasm KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.41833 BP_3 409.36 6.51 3323 642935527 XP_973346.2 1752 1.5e-192 PREDICTED: phosphoacetylglucosamine mutase [Tribolium castaneum] 629692694 XM_007813448.1 35 5.26601e-06 Metarhizium acridum CQMa 102 N-acetylglucosamine-phosphate mutase partial mRNA K01836 E5.4.2.3 phosphoacetylglucosamine mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01836 O95394 1189 1.2e-128 Phosphoacetylglucosamine mutase OS=Homo sapiens GN=PGM3 PE=1 SV=1 PF02880//PF02878//PF00408//PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II GO:0005975//GO:0071704 carbohydrate metabolic process//organic substance metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG2537 Phosphoglucomutase/phosphomannomutase Cluster-8309.41834 BP_3 67.09 0.71 4859 642933730 XP_008197339.1 4369 0.0e+00 PREDICTED: transmembrane protein 132B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q14DG7 701 6.7e-72 Transmembrane protein 132B OS=Homo sapiens GN=TMEM132B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4789 Uncharacterized conserved protein Cluster-8309.41835 BP_3 459.02 1.51 14898 642938921 XP_008195601.1 3295 0.0e+00 PREDICTED: PHD finger protein rhinoceros [Tribolium castaneum] 642938920 XM_008197379.1 365 0 PREDICTED: Tribolium castaneum PHD finger protein rhinoceros (LOC659824), mRNA -- -- -- -- Q7YZH1 1379 5.0e-150 PHD finger protein rhinoceros OS=Drosophila melanogaster GN=rno PE=1 SV=1 PF03708//PF02136//PF02214//PF00651//PF14560//PF00312//PF00130//PF00628 Avian retrovirus envelope protein, gp85//Nuclear transport factor 2 (NTF2) domain//BTB/POZ domain//BTB/POZ domain//Ubiquitin-like domain//Ribosomal protein S15//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger GO:0006810//GO:0006412//GO:0051260//GO:0042254//GO:0035556 transport//translation//protein homooligomerization//ribosome biogenesis//intracellular signal transduction GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0019031//GO:0005622//GO:0005840 viral envelope//intracellular//ribosome KOG3840 Uncharaterized conserved protein, contains BTB/POZ domain Cluster-8309.41837 BP_3 657.14 8.91 3846 642920880 XP_008192598.1 2499 4.2e-279 PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum]>gi|642920882|ref|XP_008192599.1| PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SP67 1667 5.2e-184 WD repeat-containing protein 26 OS=Danio rerio GN=wdr26 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.41838 BP_3 4.57 0.57 680 817051529 XP_012251527.1 156 3.6e-08 PREDICTED: fatty acid synthase-like [Athalia rosae] -- -- -- -- -- -- -- -- -- P19096 123 9.9e-06 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.41839 BP_3 124.27 6.49 1215 189236533 XP_975493.2 1064 3.3e-113 PREDICTED: triosephosphate isomerase [Tribolium castaneum]>gi|270005300|gb|EFA01748.1| hypothetical protein TcasGA2_TC007346 [Tribolium castaneum] 440200132 JQ784063.1 57 1.11421e-18 Eriocraniella aurosparsella voucher Erau triosephosphate isomerase mRNA, partial cds K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P30741 972 6.3e-104 Triosephosphate isomerase OS=Culex tarsalis GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006013//GO:0006000//GO:0046486//GO:0006094//GO:0015976//GO:0006020//GO:0008152//GO:0006096 mannose metabolic process//fructose metabolic process//glycerolipid metabolic process//gluconeogenesis//carbon utilization//inositol metabolic process//metabolic process//glycolytic process GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.41840 BP_3 12.83 0.50 1541 642930948 XP_008196153.1 1686 3.1e-185 PREDICTED: protein diaphanous isoform X3 [Tribolium castaneum] -- -- -- -- -- K05745 DIAPH3, DRF3 diaphanous 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05745 P48608 1243 3.0e-135 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF04614 Pex19 protein family -- -- -- -- GO:0005777 peroxisome KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.41842 BP_3 7.69 2.02 475 478258779 ENN78802.1 337 2.6e-29 hypothetical protein YQE_04739, partial [Dendroctonus ponderosae] -- -- -- -- -- K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P82204 288 5.1e-25 Triosephosphate isomerase OS=Bombyx mori GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006094//GO:0015976//GO:0046486//GO:0006000//GO:0006013//GO:0008152//GO:0006096//GO:0006020 gluconeogenesis//carbon utilization//glycerolipid metabolic process//fructose metabolic process//mannose metabolic process//metabolic process//glycolytic process//inositol metabolic process GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.41844 BP_3 2.24 0.36 592 332375176 AEE62729.1 337 3.2e-29 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P82204 288 6.3e-25 Triosephosphate isomerase OS=Bombyx mori GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006020//GO:0006096//GO:0008152//GO:0006000//GO:0046486//GO:0006013//GO:0015976//GO:0006094 inositol metabolic process//glycolytic process//metabolic process//fructose metabolic process//glycerolipid metabolic process//mannose metabolic process//carbon utilization//gluconeogenesis GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.41846 BP_3 986.68 6.92 7167 642920483 XP_008192370.1 2701 2.9e-302 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K03680 EIF2B4 translation initiation factor eIF-2B subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K03680 Q63186 925 1.1e-97 Translation initiation factor eIF-2B subunit delta OS=Rattus norvegicus GN=Eif2b4 PE=2 SV=1 PF01008//PF01763//PF02198//PF02601//PF07647//PF01496//PF00536 Initiation factor 2 subunit family//Herpesvirus UL6 like//Sterile alpha motif (SAM)/Pointed domain//Exonuclease VII, large subunit//SAM domain (Sterile alpha motif)//V-type ATPase 116kDa subunit family//SAM domain (Sterile alpha motif) GO:0015991//GO:0044237//GO:0006323//GO:0015992//GO:0006308 ATP hydrolysis coupled proton transport//cellular metabolic process//DNA packaging//proton transport//DNA catabolic process GO:0005515//GO:0008855//GO:0015078//GO:0043565 protein binding//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//sequence-specific DNA binding GO:0005634//GO:0009318//GO:0033179 nucleus//exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain KOG1467 Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2) Cluster-8309.41847 BP_3 1345.43 18.39 3818 642920481 XP_008192369.1 2064 1.1e-228 PREDICTED: liprin-beta-1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86W92 885 2.4e-93 Liprin-beta-1 OS=Homo sapiens GN=PPFIBP1 PE=1 SV=2 PF02198//PF07647//PF00536 Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus KOG0249 LAR-interacting protein and related proteins Cluster-8309.41848 BP_3 93.19 3.10 1742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41849 BP_3 62.40 0.47 6699 642936804 XP_008199623.1 6018 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 7.5e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF00910//PF08702//PF00307//PF06160//PF10473//PF07926//PF01832//PF16716//PF00004//PF13851//PF04111//PF07728//PF01695 RNA helicase//Fibrinogen alpha/beta chain family//Calponin homology (CH) domain//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//Bone marrow stromal antigen 2//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//Autophagy protein Apg6//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006560//GO:0000921//GO:0048870//GO:0051607//GO:0018874//GO:0030168//GO:0006914//GO:0051258//GO:0007165//GO:0006525//GO:0042207//GO:0006558//GO:0006568//GO:0006606 proline metabolic process//septin ring assembly//cell motility//defense response to virus//benzoate metabolic process//platelet activation//autophagy//protein polymerization//signal transduction//arginine metabolic process//styrene catabolic process//L-phenylalanine metabolic process//tryptophan metabolic process//protein import into nucleus GO:0005515//GO:0004040//GO:0003723//GO:0003724//GO:0030674//GO:0042803//GO:0045502//GO:0008134//GO:0005524//GO:0005102//GO:0016887 protein binding//amidase activity//RNA binding//RNA helicase activity//protein binding, bridging//protein homodimerization activity//dynein binding//transcription factor binding//ATP binding//receptor binding//ATPase activity GO:0005667//GO:0030286//GO:0005940//GO:0031514//GO:0016021//GO:0005577 transcription factor complex//dynein complex//septin ring//motile cilium//integral component of membrane//fibrinogen complex -- -- Cluster-8309.4185 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41850 BP_3 96.47 0.74 6611 642936804 XP_008199623.1 6018 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 7.4e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF00307//PF08702//PF00910//PF07926//PF10473//PF06160//PF13851//PF00004//PF16716//PF01832//PF07728//PF01695//PF04111 Calponin homology (CH) domain//Fibrinogen alpha/beta chain family//RNA helicase//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Growth-arrest specific micro-tubule binding//ATPase family associated with various cellular activities (AAA)//Bone marrow stromal antigen 2//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Autophagy protein Apg6 GO:0006525//GO:0007165//GO:0051258//GO:0006914//GO:0006568//GO:0006558//GO:0006606//GO:0042207//GO:0018874//GO:0048870//GO:0000921//GO:0006560//GO:0051607//GO:0030168 arginine metabolic process//signal transduction//protein polymerization//autophagy//tryptophan metabolic process//L-phenylalanine metabolic process//protein import into nucleus//styrene catabolic process//benzoate metabolic process//cell motility//septin ring assembly//proline metabolic process//defense response to virus//platelet activation GO:0005524//GO:0008134//GO:0045502//GO:0005102//GO:0016887//GO:0003723//GO:0004040//GO:0005515//GO:0042803//GO:0030674//GO:0003724 ATP binding//transcription factor binding//dynein binding//receptor binding//ATPase activity//RNA binding//amidase activity//protein binding//protein homodimerization activity//protein binding, bridging//RNA helicase activity GO:0031514//GO:0016021//GO:0005940//GO:0005577//GO:0030286//GO:0005667 motile cilium//integral component of membrane//septin ring//fibrinogen complex//dynein complex//transcription factor complex -- -- Cluster-8309.41851 BP_3 81.49 0.99 4247 642924817 XP_008194053.1 3596 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X5 [Tribolium castaneum] 749755570 XM_011141969.1 132 8.07354e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.3e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.41853 BP_3 337.00 149.44 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41854 BP_3 24.79 0.94 1558 270010741 EFA07189.1 942 5.9e-99 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 785 3.9e-82 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.41855 BP_3 72.36 1.73 2302 330417873 NP_001193392.1 1663 2.2e-182 glutathione S-transferase C-terminal domain-containing protein [Tribolium castaneum]>gi|270010443|gb|EFA06891.1| hypothetical protein TcasGA2_TC009836 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29LT4 994 3.4e-106 Glutathione S-transferase C-terminal domain-containing protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA10313 PE=3 SV=1 PF05439//PF05206//PF02527//PF02390//PF05175//PF01135 Jumping translocation breakpoint protein (JTB)//Methyltransferase TRM13//rRNA small subunit methyltransferase G//Putative methyltransferase//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006396//GO:0046500//GO:0008033//GO:0006400//GO:0000154//GO:0009451//GO:0006479//GO:0006364//GO:0006464 RNA processing//S-adenosylmethionine metabolic process//tRNA processing//tRNA modification//rRNA modification//RNA modification//protein methylation//rRNA processing//cellular protein modification process GO:0004719//GO:0008176//GO:0008168//GO:0008649 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//rRNA methyltransferase activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.41856 BP_3 21.65 0.75 1675 642929822 XP_975593.2 1030 4.0e-109 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.90535e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.4e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.41858 BP_3 140.62 1.19 5969 478256679 ENN76861.1 2137 6.2e-237 hypothetical protein YQE_06702, partial [Dendroctonus ponderosae]>gi|546685124|gb|ERL94651.1| hypothetical protein D910_11926 [Dendroctonus ponderosae] -- -- -- -- -- K12397 AP3B AP-3 complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12397 Q9Z1T1 1197 2.5e-129 AP-3 complex subunit beta-1 OS=Mus musculus GN=Ap3b1 PE=1 SV=2 PF13181//PF08492//PF13174//PF01602//PF02985//PF06459//PF02535//PF00330//PF13371//PF13374//PF00515//PF09726//PF13414//PF02486 Tetratricopeptide repeat//SRP72 RNA-binding domain//Tetratricopeptide repeat//Adaptin N terminal region//HEAT repeat//Ryanodine Receptor TM 4-6//ZIP Zinc transporter//Aconitase family (aconitate hydratase)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Transmembrane protein//TPR repeat//Replication initiation factor GO:0006265//GO:0006874//GO:0006614//GO:0055085//GO:0006816//GO:0006886//GO:0016192//GO:0006270//GO:0008152//GO:0030001 DNA topological change//cellular calcium ion homeostasis//SRP-dependent cotranslational protein targeting to membrane//transmembrane transport//calcium ion transport//intracellular protein transport//vesicle-mediated transport//DNA replication initiation//metabolic process//metal ion transport GO:0008312//GO:0046873//GO:0003677//GO:0003916//GO:0005219//GO:0005515 7S RNA binding//metal ion transmembrane transporter activity//DNA binding//DNA topoisomerase activity//ryanodine-sensitive calcium-release channel activity//protein binding GO:0005622//GO:0016021//GO:0048500//GO:0016020//GO:0030117 intracellular//integral component of membrane//signal recognition particle//membrane//membrane coat KOG1060 Vesicle coat complex AP-3, beta subunit Cluster-8309.41859 BP_3 8.44 0.62 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41861 BP_3 24.04 0.75 1843 91091818 XP_966528.1 1175 6.7e-126 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 795 3.2e-83 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007268//GO:0006811//GO:0007165 synaptic transmission//ion transport//signal transduction GO:0005234//GO:0004970//GO:0005216 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//ion channel activity GO:0016020 membrane -- -- Cluster-8309.41862 BP_3 3.00 0.74 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41863 BP_3 33.20 1.60 1292 91082921 XP_972710.1 699 7.4e-71 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] 462337062 APGK01037684.1 46 1.54628e-12 Dendroctonus ponderosae Seq01037694, whole genome shotgun sequence K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 451 1.7e-43 Annulin OS=Schistocerca americana PE=2 SV=1 PF00868//PF17070 Transglutaminase family//30S ribosomal protein Thx GO:0018149 peptide cross-linking GO:0046872//GO:0003810 metal ion binding//protein-glutamine gamma-glutamyltransferase activity GO:0005840 ribosome -- -- Cluster-8309.41864 BP_3 54.79 0.45 6167 237681143 NP_001153714.1 3148 0.0e+00 poly-(ADP-ribose) polymerase [Tribolium castaneum] 505789579 XM_004605427.1 81 2.63605e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 2434 9.5e-273 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00644//PF00645//PF02877//PF08063 Poly(ADP-ribose) polymerase catalytic domain//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Poly(ADP-ribose) polymerase, regulatory domain//PADR1 (NUC008) domain GO:0006471 protein ADP-ribosylation GO:0008270//GO:0003677//GO:0003950 zinc ion binding//DNA binding//NAD+ ADP-ribosyltransferase activity GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.41867 BP_3 83.81 0.58 7226 642920223 XP_975548.2 2786 0.0e+00 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 604 1.8e-60 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF10473//PF07926//PF04799//PF02185//PF02183//PF15898//PF17078//PF04111//PF01180//PF00170//PF04508//PF01920//PF06005 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//fzo-like conserved region//Hr1 repeat//Homeobox associated leucine zipper//cGMP-dependent protein kinase interacting domain//SWI5-dependent HO expression protein 3//Autophagy protein Apg6//Dihydroorotate dehydrogenase//bZIP transcription factor//Viral A-type inclusion protein repeat//Prefoldin subunit//Protein of unknown function (DUF904) GO:0055114//GO:0006606//GO:0006355//GO:0006914//GO:0007165//GO:0000917//GO:0043093//GO:0008053//GO:0048309//GO:0051028//GO:0006457//GO:0016032 oxidation-reduction process//protein import into nucleus//regulation of transcription, DNA-templated//autophagy//signal transduction//barrier septum assembly//FtsZ-dependent cytokinesis//mitochondrial fusion//endoplasmic reticulum inheritance//mRNA transport//protein folding//viral process GO:0016627//GO:0003700//GO:0019901//GO:0043565//GO:0051082//GO:0008134//GO:0003924//GO:0045502//GO:0042803 oxidoreductase activity, acting on the CH-CH group of donors//transcription factor activity, sequence-specific DNA binding//protein kinase binding//sequence-specific DNA binding//unfolded protein binding//transcription factor binding//GTPase activity//dynein binding//protein homodimerization activity GO:0005737//GO:0016272//GO:0016021//GO:0005741//GO:0005667//GO:0030286 cytoplasm//prefoldin complex//integral component of membrane//mitochondrial outer membrane//transcription factor complex//dynein complex -- -- Cluster-8309.41868 BP_3 128.91 1.71 3922 642928023 XP_008200123.1 1920 5.9e-212 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X1 [Tribolium castaneum]>gi|270010887|gb|EFA07335.1| hypothetical protein TcasGA2_TC015931 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.67844e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 1002 6.8e-107 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF03836//PF03938//PF16326//PF07851//PF05531//PF01920//PF10174//PF00036//PF13202//PF13833//PF13405//PF13499//PF04111//PF06005//PF10186//PF12763//PF16716 RasGAP C-terminus//Outer membrane protein (OmpH-like)//ABC transporter C-terminal domain//TMPIT-like protein//Nucleopolyhedrovirus P10 protein//Prefoldin subunit//RIM-binding protein of the cytomatrix active zone//EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Autophagy protein Apg6//Protein of unknown function (DUF904)//Vacuolar sorting 38 and autophagy-related subunit 14//Cytoskeletal-regulatory complex EF hand//Bone marrow stromal antigen 2 GO:0007264//GO:0000917//GO:0043093//GO:0006457//GO:0051607//GO:0010508//GO:0006914 small GTPase mediated signal transduction//barrier septum assembly//FtsZ-dependent cytokinesis//protein folding//defense response to virus//positive regulation of autophagy//autophagy GO:0005509//GO:0003677//GO:0005515//GO:0051082//GO:0005096 calcium ion binding//DNA binding//protein binding//unfolded protein binding//GTPase activator activity GO:0048786//GO:0005737//GO:0016272//GO:0019028//GO:0016021 presynaptic active zone//cytoplasm//prefoldin complex//viral capsid//integral component of membrane KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.41869 BP_3 19.47 0.80 1460 642920217 XP_008192253.1 612 1.0e-60 PREDICTED: zinc finger CCCH domain-containing protein 11A-like isoform X1 [Tribolium castaneum] 642920218 XM_008194032.1 148 3.48561e-69 PREDICTED: Tribolium castaneum zinc finger CCCH domain-containing protein 11A-like (LOC103312695), transcript variant X2, mRNA -- -- -- -- Q6NZF1 328 3.6e-29 Zinc finger CCCH domain-containing protein 11A OS=Mus musculus GN=Zc3h11a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41870 BP_3 111.09 0.78 7119 642920223 XP_975548.2 2830 0.0e+00 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 604 1.7e-60 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF01180//PF00170//PF02183 Dihydroorotate dehydrogenase//bZIP transcription factor//Homeobox associated leucine zipper GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0003700//GO:0016627//GO:0043565 transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex -- -- Cluster-8309.41872 BP_3 435.58 23.80 1174 642920217 XP_008192253.1 612 8.3e-61 PREDICTED: zinc finger CCCH domain-containing protein 11A-like isoform X1 [Tribolium castaneum] 642920218 XM_008194032.1 149 7.74624e-70 PREDICTED: Tribolium castaneum zinc finger CCCH domain-containing protein 11A-like (LOC103312695), transcript variant X2, mRNA -- -- -- -- Q6NZF1 328 2.9e-29 Zinc finger CCCH domain-containing protein 11A OS=Mus musculus GN=Zc3h11a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41876 BP_3 264.54 2.93 4637 642920570 XP_008192465.1 1475 2.8e-160 PREDICTED: synaptotagmin 1 isoform X1 [Tribolium castaneum] 642920569 XM_008194243.1 440 0 PREDICTED: Tribolium castaneum synaptotagmin 1 (Syt1), transcript variant X1, mRNA K15290 SYT1 synaptotagmin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15290 P21521 1327 1.7e-144 Synaptotagmin 1 OS=Drosophila melanogaster GN=Syt1 PE=1 SV=3 PF03821//PF00168//PF05478 Golgi 4-transmembrane spanning transporter//C2 domain//Prominin -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.41877 BP_3 4982.67 150.45 1888 549438543 AGX25160.1 1186 3.7e-127 cathepsin B precursor [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P90850 674 3.5e-69 Uncharacterized peptidase C1-like protein F26E4.3 OS=Caenorhabditis elegans GN=F26E4.3 PE=1 SV=3 PF04218//PF01033//PF00112//PF03051 CENP-B N-terminal DNA-binding domain//Somatomedin B domain//Papain family cysteine protease//Peptidase C1-like family GO:0007165//GO:0006955//GO:0006508 signal transduction//immune response//proteolysis GO:0005044//GO:0003677//GO:0004197//GO:0030247//GO:0008234 scavenger receptor activity//DNA binding//cysteine-type endopeptidase activity//polysaccharide binding//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.41879 BP_3 285.84 3.57 4154 642926804 XP_008195020.1 1279 1.3e-137 PREDICTED: vacuole membrane protein 1 isoform X2 [Tribolium castaneum] 241594857 XM_002404356.1 107 6.23431e-46 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q6INE8 937 2.5e-99 Vacuole membrane protein 1 OS=Xenopus laevis GN=vmp1 PE=2 SV=1 PF00323 Mammalian defensin GO:0006952 defense response -- -- GO:0005576 extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.41880 BP_3 165.52 0.84 9823 270011107 EFA07555.1 3715 0.0e+00 prospero [Tribolium castaneum] 642928392 XM_008194505.1 1357 0 PREDICTED: Tribolium castaneum homeobox protein prospero (LOC660328), transcript variant X2, mRNA -- -- -- -- P29617 1026 2.8e-109 Homeobox protein prospero OS=Drosophila melanogaster GN=pros PE=1 SV=3 PF13855//PF15556//PF05044//PF00560 Leucine rich repeat//ZW10 interactor//Homeo-prospero domain//Leucine Rich Repeat GO:0007093 mitotic cell cycle checkpoint GO:0003677//GO:0005515 DNA binding//protein binding GO:0000776 kinetochore KOG3779 Homeobox transcription factor prospero Cluster-8309.41882 BP_3 185.39 2.78 3509 642937569 XP_008199101.1 2344 3.6e-261 PREDICTED: amidophosphoribosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1926 4.4e-214 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF05195//PF00156 Aminopeptidase P, N-terminal domain//Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process GO:0004177//GO:0030145 aminopeptidase activity//manganese ion binding -- -- KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.41884 BP_3 227.20 5.68 2221 380017601 XP_003692741.1 1811 1.4e-199 PREDICTED: 5'-nucleotidase domain-containing protein 3 isoform X2 [Apis florea] -- -- -- -- -- -- -- -- -- Q6GN91 1105 4.4e-119 5'-nucleotidase domain-containing protein 3 OS=Xenopus laevis GN=nt5dc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.41885 BP_3 283.12 1.60 8841 642918564 XP_008199298.1 1086 6.8e-115 PREDICTED: large proline-rich protein BAG6 isoform X2 [Tribolium castaneum] 242016373 XM_002428751.1 60 1.78567e-19 Pediculus humanus corporis RWD domain-containing protein, putative, mRNA -- -- -- -- A4IH17 240 3.5e-18 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF05773//PF00240//PF01153//PF14560//PF07469 RWD domain//Ubiquitin family//Glypican//Ubiquitin-like domain//Domain of unknown function (DUF1518) -- -- GO:0005515//GO:0043395 protein binding//heparan sulfate proteoglycan binding GO:0016020//GO:0005578//GO:0005634 membrane//proteinaceous extracellular matrix//nucleus KOG4018 Uncharacterized conserved protein, contains RWD domain Cluster-8309.41887 BP_3 1139.84 15.24 3897 642918562 XP_008199292.1 1559 4.2e-170 PREDICTED: large proline-rich protein BAG6 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH17 362 1.1e-32 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF07469 Domain of unknown function (DUF1518) -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.4189 BP_3 320.98 3.80 4360 91089363 XP_973168.1 1457 3.2e-158 PREDICTED: protein CIP2A [Tribolium castaneum]>gi|270011435|gb|EFA07883.1| hypothetical protein TcasGA2_TC005457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41891 BP_3 12.00 0.39 1781 478263026 ENN81426.1 1545 8.1e-169 hypothetical protein YQE_02120, partial [Dendroctonus ponderosae]>gi|546686068|gb|ERL95468.1| hypothetical protein D910_12730 [Dendroctonus ponderosae] 56251666 CR676700.2 57 1.64866e-18 Tetraodon nigroviridis full-length cDNA K10755 RFC2_4 replication factor C subunit 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10755 P53033 1260 3.7e-137 Replication factor C subunit 2 OS=Gallus gallus GN=RFC2 PE=2 SV=1 PF06144//PF00004//PF01443//PF05496//PF07728//PF00910//PF00270//PF00005//PF07726//PF03266 DNA polymerase III, delta subunit//ATPase family associated with various cellular activities (AAA)//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//RNA helicase//DEAD/DEAH box helicase//ABC transporter//ATPase family associated with various cellular activities (AAA)//NTPase GO:0006281//GO:0006260//GO:0006310 DNA repair//DNA replication//DNA recombination GO:0098519//GO:0005524//GO:0016887//GO:0003887//GO:0003677//GO:0003723//GO:0003724//GO:0009378//GO:0003676 nucleotide phosphatase activity, acting on free nucleotides//ATP binding//ATPase activity//DNA-directed DNA polymerase activity//DNA binding//RNA binding//RNA helicase activity//four-way junction helicase activity//nucleic acid binding GO:0042575//GO:0009379//GO:0009360//GO:0005657 DNA polymerase complex//Holliday junction helicase complex//DNA polymerase III complex//replication fork KOG0991 Replication factor C, subunit RFC2 Cluster-8309.41892 BP_3 220.08 13.30 1089 642928725 XP_973998.2 1012 3.2e-107 PREDICTED: probable dolichol-phosphate mannosyltransferase [Tribolium castaneum] -- -- -- -- -- K00721 DPM1 dolichol-phosphate mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00721 O60762 954 6.9e-102 Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens GN=DPM1 PE=1 SV=1 PF13506 Glycosyl transferase family 21 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2978 Dolichol-phosphate mannosyltransferase Cluster-8309.41893 BP_3 475.92 26.63 1153 642928725 XP_973998.2 1039 2.5e-110 PREDICTED: probable dolichol-phosphate mannosyltransferase [Tribolium castaneum] -- -- -- -- -- K00721 DPM1 dolichol-phosphate mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00721 O60762 981 5.4e-105 Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens GN=DPM1 PE=1 SV=1 PF13506 Glycosyl transferase family 21 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2978 Dolichol-phosphate mannosyltransferase Cluster-8309.41894 BP_3 198.50 1.80 5612 189241221 XP_001812199.1 676 1.5e-67 PREDICTED: carboxypeptidase D-like [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 510 1.1e-49 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF01166//PF04952//PF07544//PF00246//PF06008//PF04977//PF16326//PF05531//PF05405 TSC-22/dip/bun family//Succinylglutamate desuccinylase / Aspartoacylase family//RNA polymerase II transcription mediator complex subunit 9//Zinc carboxypeptidase//Laminin Domain I//Septum formation initiator//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0008152//GO:0015986//GO:0006508//GO:0030155//GO:0030334//GO:0007165//GO:0045995//GO:0015992//GO:0007049//GO:0006357//GO:0006355 metabolic process//ATP synthesis coupled proton transport//proteolysis//regulation of cell adhesion//regulation of cell migration//signal transduction//regulation of embryonic development//proton transport//cell cycle//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0001104//GO:0003677//GO:0016788//GO:0003700//GO:0004181//GO:0015078//GO:0005102//GO:0008270 RNA polymerase II transcription cofactor activity//DNA binding//hydrolase activity, acting on ester bonds//transcription factor activity, sequence-specific DNA binding//metallocarboxypeptidase activity//hydrogen ion transmembrane transporter activity//receptor binding//zinc ion binding GO:0005667//GO:0016592//GO:0019028 transcription factor complex//mediator complex//viral capsid KOG2649 Zinc carboxypeptidase Cluster-8309.41895 BP_3 73.55 0.62 6012 91080927 XP_974039.1 6560 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3107 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF02207//PF04183//PF01599//PF02617 Putative zinc finger in N-recognin (UBR box)//IucA / IucC family//Ribosomal protein S27a//ATP-dependent Clp protease adaptor protein ClpS GO:0042254//GO:0030163//GO:0006826//GO:0019290//GO:0006412//GO:0016567 ribosome biogenesis//protein catabolic process//iron ion transport//siderophore biosynthetic process//translation//protein ubiquitination GO:0003735//GO:0015343//GO:0008270//GO:0004842 structural constituent of ribosome//siderophore transmembrane transporter activity//zinc ion binding//ubiquitin-protein transferase activity GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.41896 BP_3 1273.00 34.22 2085 478252467 ENN72889.1 852 2.2e-88 hypothetical protein YQE_10459, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF00822//PF13903 Clc-like//PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41898 BP_3 52.06 0.90 3091 642911903 XP_008199015.1 866 7.7e-90 PREDICTED: heat shock factor protein-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K09414 HSF1 heat shock transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09414 P22813 420 1.6e-39 Heat shock factor protein OS=Drosophila melanogaster GN=Hsf PE=1 SV=1 PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0627 Heat shock transcription factor Cluster-8309.41899 BP_3 1228.84 8.45 7303 642911903 XP_008199015.1 1233 5.0e-132 PREDICTED: heat shock factor protein-like isoform X3 [Tribolium castaneum] 642911902 XM_008200793.1 159 1.36339e-74 PREDICTED: Tribolium castaneum heat shock factor protein-like (LOC103314511), transcript variant X4, mRNA K09414 HSF1 heat shock transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09414 P22813 658 9.8e-67 Heat shock factor protein OS=Drosophila melanogaster GN=Hsf PE=1 SV=1 PF00637//PF00447 Region in Clathrin and VPS//HSF-type DNA-binding GO:0006886//GO:0016192//GO:0006355 intracellular protein transport//vesicle-mediated transport//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0627 Heat shock transcription factor Cluster-8309.41901 BP_3 28.59 1.00 1669 642926100 XP_008194784.1 875 3.7e-91 PREDICTED: polycomb complex protein BMI-1-A [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 Q91648 604 4.1e-61 Polycomb complex protein BMI-1-A OS=Xenopus laevis GN=bmi1a PE=1 SV=1 PF13639//PF03315//PF03854//PF01213//PF10099//PF03341//PF11789//PF00097//PF12678//PF14634 Ring finger domain//Serine dehydratase beta chain//P-11 zinc finger//Adenylate cyclase associated (CAP) N terminal//Anti-sigma-K factor rskA//Poxvirus mRNA capping enzyme, small subunit//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain GO:0006544//GO:0006370//GO:0009451//GO:0006534//GO:0007010//GO:0006563//GO:0006094//GO:0006566 glycine metabolic process//7-methylguanosine mRNA capping//RNA modification//cysteine metabolic process//cytoskeleton organization//L-serine metabolic process//gluconeogenesis//threonine metabolic process GO:0005515//GO:0003723//GO:0004482//GO:0046872//GO:0003779//GO:0051539//GO:0003941//GO:0008270 protein binding//RNA binding//mRNA (guanine-N7-)-methyltransferase activity//metal ion binding//actin binding//4 iron, 4 sulfur cluster binding//L-serine ammonia-lyase activity//zinc ion binding GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG2660 Locus-specific chromosome binding proteins Cluster-8309.41902 BP_3 158.71 18.87 697 676490959 XP_009065437.1 141 2.0e-06 hypothetical protein LOTGIDRAFT_132613, partial [Lottia gigantea]>gi|556095205|gb|ESO83858.1| hypothetical protein LOTGIDRAFT_132613, partial [Lottia gigantea] 9809 X13039.1 71 1.03319e-26 Philosamia cynthia ricini 5S rRNA -- -- -- -- -- -- -- -- PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.41903 BP_3 250.00 49.92 533 642938085 XP_008190376.1 401 1.1e-36 PREDICTED: histone H1-III-like [Tribolium castaneum] -- -- -- -- -- K11275 H1_5 histone H1/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11275 P40265 304 8.0e-27 Histone H1-III OS=Glyptotendipes barbipes PE=3 SV=1 PF00538//PF06333 linker histone H1 and H5 family//Mediator complex subunit 13 C-terminal GO:0006357//GO:0006334 regulation of transcription from RNA polymerase II promoter//nucleosome assembly GO:0003677//GO:0001104 DNA binding//RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592//GO:0000786 nucleus//mediator complex//nucleosome -- -- Cluster-8309.41904 BP_3 788.79 4.93 8002 642937407 XP_008198823.1 2893 0.0e+00 PREDICTED: dynamin isoform X2 [Tribolium castaneum] 665799739 XM_008549577.1 312 1.32519e-159 PREDICTED: Microplitis demolitor dynamin-like (LOC103571419), mRNA K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 2535 2.4e-284 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF01926//PF01031//PF08023//PF02212 50S ribosome-binding GTPase//Dynamin central region//Frog antimicrobial peptide//Dynamin GTPase effector domain GO:0006952 defense response GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005576 extracellular region KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.41905 BP_3 57.31 0.77 3869 189234531 XP_967948.2 893 7.1e-93 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 711 3.7e-73 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522//PF13520 Amino acid permease//Solute carrier family 12//Amino acid permease GO:0006811//GO:0003333//GO:0006810//GO:0055085//GO:0006865 ion transport//amino acid transmembrane transport//transport//transmembrane transport//amino acid transport GO:0005215//GO:0015171 transporter activity//amino acid transmembrane transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.41906 BP_3 14.35 0.72 1257 270009170 EFA05618.1 298 2.3e-24 hypothetical protein TcasGA2_TC015826 [Tribolium castaneum] 170055484 XM_001863568.1 108 5.14533e-47 Culex quinquefasciatus conserved hypothetical protein, mRNA K11422 SETD1, SET1 histone-lysine N-methyltransferase SETD1 http://www.genome.jp/dbget-bin/www_bget?ko:K11422 Q5LJZ2 290 7.9e-25 Histone-lysine N-methyltransferase SETD1 OS=Drosophila melanogaster GN=Set1 PE=1 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.41907 BP_3 446.70 15.51 1680 642916441 XP_008191028.1 1494 6.3e-163 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X2 [Tribolium castaneum] 572301862 XM_006616904.1 66 1.54234e-23 PREDICTED: Apis dorsata transmembrane and coiled-coil domains protein 2-like (LOC102681558), transcript variant X6, mRNA -- -- -- -- Q80W04 671 7.0e-69 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF08702//PF04513//PF02601//PF02184//PF05073//PF03462//PF05478//PF05929//PF12919//PF05531//PF07851 Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//HAT (Half-A-TPR) repeat//Baculovirus P24 capsid protein//PCRF domain//Prominin//Phage capsid scaffolding protein (GPO) serine peptidase//TcdA/TcdB catalytic glycosyltransferase domain//Nucleopolyhedrovirus P10 protein//TMPIT-like protein GO:0006449//GO:0030168//GO:0006308//GO:0019069//GO:0007165//GO:0051258//GO:0006415//GO:0006396 regulation of translational termination//platelet activation//DNA catabolic process//viral capsid assembly//signal transduction//protein polymerization//translational termination//RNA processing GO:0008855//GO:0016149//GO:0030674//GO:0016757//GO:0005198//GO:0005102 exodeoxyribonuclease VII activity//translation release factor activity, codon specific//protein binding, bridging//transferase activity, transferring glycosyl groups//structural molecule activity//receptor binding GO:0019031//GO:0016021//GO:0019028//GO:0009318//GO:0005840//GO:0005622//GO:0018444//GO:0005577//GO:0005737 viral envelope//integral component of membrane//viral capsid//exodeoxyribonuclease VII complex//ribosome//intracellular//translation release factor complex//fibrinogen complex//cytoplasm KOG3850 Predicted membrane protein Cluster-8309.41911 BP_3 806.79 7.82 5262 642914743 XP_008190334.1 2249 5.6e-250 PREDICTED: uncharacterized protein LOC655834 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H4G4 301 1.8e-25 Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens GN=GLIPR2 PE=1 SV=3 PF02038 ATP1G1/PLM/MAT8 family GO:0006811 ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.41912 BP_3 76.27 2.09 2052 642936475 XP_008198451.1 1608 4.6e-176 PREDICTED: LOW QUALITY PROTEIN: G protein-coupled receptor kinase 2 [Tribolium castaneum] 642936474 XM_008200229.1 480 0 PREDICTED: Tribolium castaneum G protein-coupled receptor kinase 2 (LOC656376), mRNA K08291 GRK4_5_6 G protein-coupled receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08291 P43249 1045 3.7e-112 G protein-coupled receptor kinase 5 OS=Bos taurus GN=GRK5 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0986 G protein-coupled receptor kinase Cluster-8309.41913 BP_3 937.91 7.82 6069 546670634 ERL83320.1 5425 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.39562e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q8NFA0 1141 8.0e-123 Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens GN=USP32 PE=1 SV=1 PF13499//PF00036//PF05191//PF13405//PF06337//PF11421//PF00443 EF-hand domain pair//EF hand//Adenylate kinase, active site lid//EF-hand domain//DUSP domain//ATP synthase F1 beta subunit//Ubiquitin carboxyl-terminal hydrolase GO:0006144//GO:0046034//GO:0006508//GO:0016579//GO:0006754 purine nucleobase metabolic process//ATP metabolic process//proteolysis//protein deubiquitination//ATP biosynthetic process GO:0004843//GO:0005524//GO:0036459//GO:0016887//GO:0005509//GO:0004017 ubiquitin-specific protease activity//ATP binding//ubiquitinyl hydrolase activity//ATPase activity//calcium ion binding//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.41915 BP_3 11.00 0.52 1317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41916 BP_3 106.05 0.64 8239 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 133 4.37084e-60 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.4e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF12861//PF09726//PF13639//PF01165//PF00637//PF17122//PF00097//PF14634//PF02148//PF02723//PF12678//PF08496//PF00569//PF00443 Anaphase-promoting complex subunit 11 RING-H2 finger//Transmembrane protein//Ring finger domain//Ribosomal protein S21//Region in Clathrin and VPS//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Zn-finger in ubiquitin-hydrolases and other protein//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//Peptidase family S49 N-terminal//Zinc finger, ZZ type//Ubiquitin carboxyl-terminal hydrolase GO:0006412//GO:0016567//GO:0006886//GO:0016192//GO:0042254//GO:0016579 translation//protein ubiquitination//intracellular protein transport//vesicle-mediated transport//ribosome biogenesis//protein deubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0036459//GO:0003735//GO:0008270//GO:0004252 ubiquitin-protein transferase activity//protein binding//metal ion binding//ubiquitinyl hydrolase activity//structural constituent of ribosome//zinc ion binding//serine-type endopeptidase activity GO:0005886//GO:0005680//GO:0016020//GO:0016021//GO:0005840 plasma membrane//anaphase-promoting complex//membrane//integral component of membrane//ribosome KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.41917 BP_3 139.82 2.94 2587 642920758 XP_971086.2 1029 8.1e-109 PREDICTED: protein-L-isoaspartate(D-aspartate) O-methyltransferase [Tribolium castaneum] 242014347 XM_002427808.1 67 6.65268e-24 Pediculus humanus corporis protein-L-isoaspartate O-methyltransferase, putative, mRNA K00573 E2.1.1.77, pcm protein-L-isoaspartate(D-aspartate) O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00573 Q5F3N1 775 9.4e-81 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Gallus gallus GN=PCMT1 PE=2 SV=3 PF01209//PF01596//PF08241//PF05175//PF01135 ubiE/COQ5 methyltransferase family//O-methyltransferase//Methyltransferase domain//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0008152//GO:0006464//GO:0006479//GO:0046500 metabolic process//cellular protein modification process//protein methylation//S-adenosylmethionine metabolic process GO:0008168//GO:0004719//GO:0008171 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//O-methyltransferase activity -- -- KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.41923 BP_3 1493.21 9.98 7504 642912357 XP_008199608.1 1411 1.2e-152 PREDICTED: PHD and RING finger domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17586 PHRF1 PHD and RING finger domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17586 Q63625 468 1.1e-44 PHD and RING finger domain-containing protein 1 OS=Rattus norvegicus GN=Phrf1 PE=1 SV=2 PF13639//PF03854//PF13994//PF12861//PF00130//PF00097//PF17123//PF12678//PF00628//PF14634 Ring finger domain//P-11 zinc finger//PgaD-like protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//PHD-finger//zinc-RING finger domain GO:0035556//GO:0042710//GO:0016567 intracellular signal transduction//biofilm formation//protein ubiquitination GO:0046872//GO:0008270//GO:0004842//GO:0005515//GO:0003723 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding//RNA binding GO:0005680 anaphase-promoting complex KOG0825 PHD Zn-finger protein Cluster-8309.41924 BP_3 1598.10 10.41 7688 189241221 XP_001812199.1 1084 1.0e-114 PREDICTED: carboxypeptidase D-like [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 746 6.4e-77 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF00246//PF00018//PF06008//PF05531//PF01166//PF04952//PF07544 Zinc carboxypeptidase//SH3 domain//Laminin Domain I//Nucleopolyhedrovirus P10 protein//TSC-22/dip/bun family//Succinylglutamate desuccinylase / Aspartoacylase family//RNA polymerase II transcription mediator complex subunit 9 GO:0008152//GO:0006508//GO:0030155//GO:0007165//GO:0030334//GO:0045995//GO:0006357//GO:0006355 metabolic process//proteolysis//regulation of cell adhesion//signal transduction//regulation of cell migration//regulation of embryonic development//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0005515//GO:0001104//GO:0016788//GO:0004181//GO:0003700//GO:0005102//GO:0008270 protein binding//RNA polymerase II transcription cofactor activity//hydrolase activity, acting on ester bonds//metallocarboxypeptidase activity//transcription factor activity, sequence-specific DNA binding//receptor binding//zinc ion binding GO:0005667//GO:0016592//GO:0019028 transcription factor complex//mediator complex//viral capsid KOG2649 Zinc carboxypeptidase Cluster-8309.41925 BP_3 74.86 0.89 4354 642910515 XP_971774.3 1378 4.6e-149 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] 642910514 XM_966681.3 50 3.17329e-14 PREDICTED: Tribolium castaneum leucine-rich repeats and immunoglobulin-like domains protein 2 (LOC660451), transcript variant X2, mRNA -- -- -- -- Q6P1C6 818 1.6e-85 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Mus musculus GN=Lrig3 PE=1 SV=1 PF01195//PF13895//PF06667//PF13855//PF00560//PF05790//PF02924 Peptidyl-tRNA hydrolase//Immunoglobulin domain//Phage shock protein B//Leucine rich repeat//Leucine Rich Repeat//Immunoglobulin C2-set domain//Bacteriophage lambda head decoration protein D GO:0009271//GO:0007155//GO:0006355 phage shock//cell adhesion//regulation of transcription, DNA-templated GO:0004045//GO:0005515 aminoacyl-tRNA hydrolase activity//protein binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG4194 Membrane glycoprotein LIG-1 Cluster-8309.41926 BP_3 73.37 1.03 3740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02798//PF09807 Glutathione S-transferase, N-terminal domain//Elongation complex protein 6 -- -- GO:0005515 protein binding GO:0033588 Elongator holoenzyme complex -- -- Cluster-8309.41927 BP_3 4.58 0.97 518 270002107 EEZ98554.1 153 6.1e-08 hypothetical protein TcasGA2_TC001061 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41929 BP_3 199.97 1.45 6939 642913880 XP_008201199.1 5718 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X2 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.35125e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q8TDW5 642 6.7e-65 Synaptotagmin-like protein 5 OS=Homo sapiens GN=SYTL5 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.41931 BP_3 19.18 0.44 2395 91079744 XP_970506.1 923 1.5e-96 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 768418016 XM_011551374.1 201 1.98993e-98 PREDICTED: Plutella xylostella probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial (LOC105381602), transcript variant X5, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 905 7.3e-96 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF02770//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.41932 BP_3 19.19 0.41 2573 642927014 XP_001810799.2 621 1.6e-61 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9J0 162 1.1e-09 Peroxisomal leader peptide-processing protease OS=Homo sapiens GN=TYSND1 PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41933 BP_3 125.43 3.30 2121 195356716 XP_002044796.1 166 7.8e-09 GM13286 [Drosophila sechellia]>gi|194121629|gb|EDW43672.1| GM13286 [Drosophila sechellia] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41934 BP_3 16.30 0.53 1771 642919169 XP_008191766.1 1427 3.9e-155 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q810J8 982 6.4e-105 Zinc finger FYVE domain-containing protein 1 OS=Mus musculus GN=Zfyve1 PE=2 SV=2 PF02263//PF04548//PF01926 Guanylate-binding protein, N-terminal domain//AIG1 family//50S ribosome-binding GTPase -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- -- -- Cluster-8309.41935 BP_3 121.26 2.49 2641 642938917 XP_001808877.2 932 1.5e-97 PREDICTED: suppressor protein SRP40-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03884 Domain of unknown function (DUF329) -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.41936 BP_3 1559.41 43.69 2012 642914207 XP_008201590.1 805 5.9e-83 PREDICTED: uncharacterized protein LOC661830 isoform X5 [Tribolium castaneum] 827545791 XM_004925600.2 39 1.89338e-08 PREDICTED: Bombyx mori uncharacterized LOC101735549 (LOC101735549), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.41937 BP_3 310.53 5.51 3009 270007326 EFA03774.1 1530 7.5e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 843 1.4e-88 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF02456//PF01612//PF08066 Adenovirus IVa2 protein//3'-5' exonuclease//PMC2NT (NUC016) domain GO:0006139//GO:0006396//GO:0019083 nucleobase-containing compound metabolic process//RNA processing//viral transcription GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.41940 BP_3 1027.04 11.12 4742 642927612 XP_973436.3 1023 7.3e-108 PREDICTED: cell growth regulator with RING finger domain protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24799 317 2.2e-27 Myophilin OS=Echinococcus granulosus PE=2 SV=1 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.41941 BP_3 4.92 0.80 588 642926574 XP_008194926.1 315 1.1e-26 PREDICTED: scavenger receptor class B member 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10766 Multidrug efflux pump-associated protein AcrZ GO:0006855//GO:0015893 drug transmembrane transport//drug transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.41942 BP_3 491.61 5.43 4653 642914864 XP_008195077.1 2183 2.2e-242 PREDICTED: myosin light chain kinase, smooth muscle-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q28824 825 2.7e-86 Myosin light chain kinase, smooth muscle OS=Bos taurus GN=MYLK PE=1 SV=1 PF07714//PF00631//PF06293//PF00069 Protein tyrosine kinase//GGL domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0007186//GO:0007165//GO:0006468 G-protein coupled receptor signaling pathway//signal transduction//protein phosphorylation GO:0016773//GO:0004871//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//signal transducer activity//protein kinase activity//ATP binding GO:0016020//GO:0005834 membrane//heterotrimeric G-protein complex KOG0613 Projectin/twitchin and related proteins Cluster-8309.41945 BP_3 1441.96 18.70 4008 91090288 XP_971422.1 2498 5.7e-279 PREDICTED: pre-rRNA processing protein FTSJ3 [Tribolium castaneum]>gi|270013436|gb|EFA09884.1| hypothetical protein TcasGA2_TC012032 [Tribolium castaneum] 751213900 XM_011161477.1 235 4.21021e-117 PREDICTED: Solenopsis invicta pre-rRNA processing protein FTSJ3 (LOC105195860), mRNA K14857 SPB1, FTSJ3 AdoMet-dependent rRNA methyltransferase SPB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14857 Q5ZKM1 1045 7.2e-112 pre-rRNA processing protein FTSJ3 OS=Gallus gallus GN=FTSJ3 PE=2 SV=2 PF01728//PF07780//PF00844 FtsJ-like methyltransferase//Spb1 C-terminal domain//Geminivirus coat protein/nuclear export factor BR1 family GO:0006364//GO:0008152//GO:0032259 rRNA processing//metabolic process//methylation GO:0008168//GO:0005198 methyltransferase activity//structural molecule activity GO:0019028//GO:0005634 viral capsid//nucleus KOG1098 Putative SAM-dependent rRNA methyltransferase SPB1 Cluster-8309.41949 BP_3 1281.03 5.17 12227 270001010 EEZ97457.1 2072 4.3e-229 hypothetical protein TcasGA2_TC011288 [Tribolium castaneum] 662203988 XM_008477133.1 151 6.40478e-70 PREDICTED: Diaphorina citri calcium-activated potassium channel slowpoke-like (LOC103512372), mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1831 1.6e-202 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF12905//PF00397 Endo-alpha-N-acetylgalactosaminidase//WW domain -- -- GO:0033926//GO:0005515 glycopeptide alpha-N-acetylgalactosaminidase activity//protein binding -- -- KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.4195 BP_3 2.00 0.41 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41950 BP_3 359.00 3.22 5665 642937243 XP_008198753.1 2474 4.9e-276 PREDICTED: aryl hydrocarbon receptor [Tribolium castaneum] 197108533 EU912437.1 523 0 Tribolium castaneum spineless mRNA, partial cds -- -- -- -- Q8R4S4 951 8.0e-101 Aryl hydrocarbon receptor OS=Mus spicilegus GN=Ahr PE=2 SV=1 PF04062//PF08447//PF00010//PF00989 ARP2/3 complex ARPC3 (21 kDa) subunit//PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0030833//GO:0034314//GO:0006355 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation//regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity GO:0005856//GO:0005885 cytoskeleton//Arp2/3 protein complex KOG3560 Aryl-hydrocarbon receptor Cluster-8309.41951 BP_3 50.92 1.37 2088 768443595 XP_011563618.1 837 1.2e-86 PREDICTED: uncharacterized protein LOC105393537 [Plutella xylostella] -- -- -- -- -- -- -- -- -- P03352 132 2.8e-06 Gag polyprotein OS=Maedi visna virus (strain 1514) GN=gag PE=3 SV=1 PF00098//PF09668 Zinc knuckle//Aspartyl protease GO:0006508 proteolysis GO:0008270//GO:0003676//GO:0004190 zinc ion binding//nucleic acid binding//aspartic-type endopeptidase activity -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.41952 BP_3 1530.25 58.02 1563 478256432 ENN76619.1 1029 4.9e-109 hypothetical protein YQE_06876, partial [Dendroctonus ponderosae] 766918334 XM_011499440.1 192 1.29755e-93 PREDICTED: Ceratosolen solmsi marchali protein enhancer of sevenless 2B (LOC105362095), mRNA K04364 GRB2 growth factor receptor-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04364 Q08012 948 4.9e-101 Protein enhancer of sevenless 2B OS=Drosophila melanogaster GN=drk PE=1 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains Cluster-8309.41953 BP_3 113.91 2.07 2946 332374296 AEE62289.1 1127 4.0e-120 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 1.9e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.41954 BP_3 561.78 5.08 5626 91092690 XP_971771.1 1827 5.1e-201 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 6.18217e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K04454 MEF2C MADS-box transcription enhancer factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K04454 P40791 941 1.2e-99 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF00319//PF03554 SRF-type transcription factor (DNA-binding and dimerisation domain)//UL73 viral envelope glycoprotein -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.41955 BP_3 5713.12 81.15 3685 270014029 EFA10477.1 699 2.1e-70 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 1.23012e-22 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- O94842 173 8.6e-11 TOX high mobility group box family member 4 OS=Homo sapiens GN=TOX4 PE=1 SV=1 PF11770//PF03460 GRB2-binding adapter (GAPT)//Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.41956 BP_3 1139.15 15.10 3928 642936984 XP_008198642.1 2321 1.9e-258 PREDICTED: bromodomain-containing protein 3-like isoform X5 [Tribolium castaneum] 751803975 XM_011213848.1 114 7.56827e-50 PREDICTED: Bactrocera dorsalis homeotic protein female sterile-like (LOC105232218), mRNA K11721 BRD3 bromodomain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11721 Q15059 993 7.5e-106 Bromodomain-containing protein 3 OS=Homo sapiens GN=BRD3 PE=1 SV=1 PF13965//PF00439//PF08290//PF12761//PF01025//PF02325//PF03938 dsRNA-gated channel SID-1//Bromodomain//Hepatitis core protein, putative zinc finger//Actin cytoskeleton-regulatory complex protein END3//GrpE//YGGT family//Outer membrane protein (OmpH-like) GO:0006897//GO:0007015//GO:0006457//GO:0009405//GO:0015931//GO:0033227 endocytosis//actin filament organization//protein folding//pathogenesis//nucleobase-containing compound transport//dsRNA transport GO:0005515//GO:0005198//GO:0051033//GO:0000774//GO:0051087//GO:0042803//GO:0051082 protein binding//structural molecule activity//RNA transmembrane transporter activity//adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity//unfolded protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1474 Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins Cluster-8309.41957 BP_3 41.02 0.42 5013 642936988 XP_008198644.1 722 6.2e-73 PREDICTED: bromodomain-containing protein 3-like isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13709 137 1.7e-06 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 PF01397//PF04055 Terpene synthase, N-terminal domain//Radical SAM superfamily GO:0008152 metabolic process GO:0003824//GO:0051536//GO:0016829//GO:0010333 catalytic activity//iron-sulfur cluster binding//lyase activity//terpene synthase activity -- -- -- -- Cluster-8309.4196 BP_3 3.36 1.03 449 91087755 XP_974940.1 395 4.6e-36 PREDICTED: protein FAM50 homolog [Tribolium castaneum]>gi|270009391|gb|EFA05839.1| hypothetical protein TcasGA2_TC008623 [Tribolium castaneum] -- -- -- -- -- K13119 FAM50, XAP5 protein FAM50 http://www.genome.jp/dbget-bin/www_bget?ko:K13119 Q299F9 371 1.1e-34 Protein FAM50 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA11514 PE=3 SV=1 -- -- -- -- -- -- GO:0005634 nucleus KOG2894 Uncharacterized conserved protein XAP-5 Cluster-8309.41960 BP_3 124.25 2.42 2770 270004866 EFA01314.1 634 5.5e-63 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 473 1.1e-45 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41961 BP_3 37.00 31.98 341 270004866 EFA01314.1 286 1.5e-23 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 215 1.1e-16 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41962 BP_3 1124.12 35.41 1822 642915333 XP_008190576.1 659 4.5e-66 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 484 3.7e-47 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 PF00034 Cytochrome c GO:0006118 obsolete electron transport GO:0009055//GO:0020037 electron carrier activity//heme binding -- -- -- -- Cluster-8309.41964 BP_3 5.44 0.49 823 642915333 XP_008190576.1 611 7.6e-61 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 442 1.2e-42 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41967 BP_3 115.73 0.49 11695 270014366 EFA10814.1 3212 0.0e+00 hypothetical protein TcasGA2_TC030632 [Tribolium castaneum] 642940046 XM_008194216.1 41 8.62557e-09 PREDICTED: Tribolium castaneum uncharacterized LOC103312751 (LOC103312751), mRNA K11984 SART1, HAF, SNU66 U4/U6.U5 tri-snRNP-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11984 O43290 908 1.6e-95 U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens GN=SART1 PE=1 SV=1 PF00569//PF00856//PF01033//PF00628//PF03343//PF07496//PF03412 Zinc finger, ZZ type//SET domain//Somatomedin B domain//PHD-finger//SART-1 family//CW-type Zinc Finger//Peptidase C39 family GO:0006508//GO:0006955//GO:0000398//GO:0007165 proteolysis//immune response//mRNA splicing, via spliceosome//signal transduction GO:0030247//GO:0008270//GO:0008233//GO:0005044//GO:0005524//GO:0005515 polysaccharide binding//zinc ion binding//peptidase activity//scavenger receptor activity//ATP binding//protein binding GO:0016021 integral component of membrane KOG2217 U4/U6.U5 snRNP associated protein Cluster-8309.4197 BP_3 17.00 0.33 2754 270012958 EFA09406.1 528 1.1e-50 hypothetical protein TcasGA2_TC004324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03824//PF01530 High-affinity nickel-transport protein//Zinc finger, C2HC type GO:0006355//GO:0035444//GO:0015675 regulation of transcription, DNA-templated//nickel cation transmembrane transport//nickel cation transport GO:0015099//GO:0008270//GO:0003700//GO:0046872 nickel cation transmembrane transporter activity//zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0016021//GO:0005634//GO:0005667 integral component of membrane//nucleus//transcription factor complex KOG3803 Transcription factor containing C2HC type Zn finger Cluster-8309.41971 BP_3 2823.60 203.96 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03525 Meiotic recombination protein rec114 GO:0007131 reciprocal meiotic recombination -- -- -- -- -- -- Cluster-8309.41973 BP_3 5.05 0.38 937 665786917 XP_008554781.1 386 1.1e-34 PREDICTED: [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Microplitis demolitor] -- -- -- -- -- K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00898 P91622 375 8.2e-35 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0787 Dehydrogenase kinase Cluster-8309.41974 BP_3 257.60 16.59 1040 91092090 XP_971602.1 380 5.8e-34 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 -- -- -- -- PF07655 Secretin N-terminal domain GO:0009297 pilus assembly GO:0005488 binding GO:0019867 outer membrane -- -- Cluster-8309.41976 BP_3 67.00 3.86 1129 478253256 ENN73627.1 303 5.4e-25 hypothetical protein YQE_09874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41977 BP_3 1808.25 7.98 11213 642910658 XP_008200046.1 10447 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.41978 BP_3 170.16 2.04 4313 91078140 XP_973588.1 263 8.9e-20 PREDICTED: uncharacterized protein LOC662397 [Tribolium castaneum]>gi|270002341|gb|EEZ98788.1| hypothetical protein TcasGA2_TC001352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4198 BP_3 77.21 1.73 2449 642914380 XP_008201654.1 393 4.3e-35 PREDICTED: keratin, type I cytoskeletal 9-like [Tribolium castaneum]>gi|270001553|gb|EEZ98000.1| hypothetical protein TcasGA2_TC000398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41980 BP_3 574.93 9.36 3251 91080077 XP_967815.1 1369 3.8e-148 PREDICTED: gamma-soluble NSF attachment protein [Tribolium castaneum]>gi|270003201|gb|EEZ99648.1| hypothetical protein TcasGA2_TC002405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81127 584 1.7e-58 Gamma-soluble NSF attachment protein OS=Bos taurus GN=NAPG PE=1 SV=3 PF13414//PF13176//PF06552//PF07721//PF00515//PF03930 TPR repeat//Tetratricopeptide repeat//Plant specific mitochondrial import receptor subunit TOM20//Tetratricopeptide repeat//Tetratricopeptide repeat//Recombinase Flp protein N-terminus GO:0006886//GO:0045040//GO:0006310 intracellular protein transport//protein import into mitochondrial outer membrane//DNA recombination GO:0005515//GO:0042802 protein binding//identical protein binding GO:0005742//GO:0005622 mitochondrial outer membrane translocase complex//intracellular KOG1585 Protein required for fusion of vesicles in vesicular transport, gamma-SNAP Cluster-8309.41981 BP_3 226.07 3.12 3784 91080077 XP_967815.1 1036 1.8e-109 PREDICTED: gamma-soluble NSF attachment protein [Tribolium castaneum]>gi|270003201|gb|EEZ99648.1| hypothetical protein TcasGA2_TC002405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81127 363 8.2e-33 Gamma-soluble NSF attachment protein OS=Bos taurus GN=NAPG PE=1 SV=3 PF13414//PF13176//PF03930 TPR repeat//Tetratricopeptide repeat//Recombinase Flp protein N-terminus GO:0006310//GO:0006886 DNA recombination//intracellular protein transport GO:0005515 protein binding GO:0005622 intracellular KOG1585 Protein required for fusion of vesicles in vesicular transport, gamma-SNAP Cluster-8309.41983 BP_3 20.24 1.73 855 -- -- -- -- -- 642919184 XM_962644.3 56 2.78909e-18 PREDICTED: Tribolium castaneum transcription factor AP-4 (LOC656093), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41984 BP_3 783.74 6.65 5971 642919201 XP_967817.2 3104 0.0e+00 PREDICTED: polycomb protein Sfmbt [Tribolium castaneum] 591292165 XM_007073353.1 60 1.20415e-19 PREDICTED: Panthera tigris altaica transcription factor AP-4 (activating enhancer binding protein 4) (TFAP4), mRNA -- -- -- -- Q29L50 1530 6.2e-168 Polycomb protein Sfmbt OS=Drosophila pseudoobscura pseudoobscura GN=Sfmbt PE=3 SV=2 PF03840//PF00975//PF05577//PF07819//PF08114//PF02198//PF00536//PF02069//PF02820//PF00010//PF07647 Preprotein translocase SecG subunit//Thioesterase domain//Serine carboxypeptidase S28//PGAP1-like protein//ATPase proteolipid family//Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//Prokaryotic metallothionein//mbt repeat//Helix-loop-helix DNA-binding domain//SAM domain (Sterile alpha motif) GO:0006505//GO:0006886//GO:0009306//GO:0006355//GO:0015031//GO:0009058//GO:0006508//GO:0050790 GPI anchor metabolic process//intracellular protein transport//protein secretion//regulation of transcription, DNA-templated//protein transport//biosynthetic process//proteolysis//regulation of catalytic activity GO:0043565//GO:0008236//GO:0030234//GO:0016788//GO:0005515//GO:0046983//GO:0015450//GO:0046872 sequence-specific DNA binding//serine-type peptidase activity//enzyme regulator activity//hydrolase activity, acting on ester bonds//protein binding//protein dimerization activity//P-P-bond-hydrolysis-driven protein transmembrane transporter activity//metal ion binding GO:0009941//GO:0016021//GO:0005634 chloroplast envelope//integral component of membrane//nucleus -- -- Cluster-8309.41987 BP_3 53.32 0.52 5195 270011060 EFA07508.1 3837 0.0e+00 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20742 1226 9.5e-133 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 PF07678//PF07677//PF01835//PF00207//PF01483//PF00873 A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain//Alpha-2-macroglobulin family//Proprotein convertase P-domain//AcrB/AcrD/AcrF family GO:0006508//GO:0006810 proteolysis//transport GO:0004252//GO:0005215//GO:0004866 serine-type endopeptidase activity//transporter activity//endopeptidase inhibitor activity GO:0005576//GO:0016020//GO:0005615 extracellular region//membrane//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.41988 BP_3 760.00 18.35 2288 546676955 ERL87879.1 737 5.2e-75 hypothetical protein D910_05267 [Dendroctonus ponderosae] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P20350 286 4.2e-24 Protein rhomboid OS=Drosophila melanogaster GN=rho PE=1 SV=2 PF10591//PF13405//PF13833//PF00036//PF13499//PF01694//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//Rhomboid family//EF hand GO:0007165 signal transduction GO:0004252//GO:0005509 serine-type endopeptidase activity//calcium ion binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.41989 BP_3 327.14 22.45 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00106//PF01370//PF02558 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA GO:0055114//GO:0015940//GO:0008152 oxidation-reduction process//pantothenate biosynthetic process//metabolic process GO:0016491//GO:0008677//GO:0003824//GO:0050662 oxidoreductase activity//2-dehydropantoate 2-reductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.41991 BP_3 188.24 1.59 5991 642918310 XP_008191453.1 4768 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] -- -- -- -- -- K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 Q96PE3 739 3.3e-76 Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.41994 BP_3 52.00 1.16 2444 546672885 ERL84608.1 1010 1.2e-106 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 774 1.2e-80 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF15681//PF00067//PF08545//PF00108 Lymphocyte activation family X//Cytochrome P450//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0055114//GO:0006955//GO:0051249//GO:0042967//GO:0008152//GO:0006633 oxidation-reduction process//immune response//regulation of lymphocyte activation//acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process GO:0016747//GO:0005506//GO:0020037//GO:0004315//GO:0016705 transferase activity, transferring acyl groups other than amino-acyl groups//iron ion binding//heme binding//3-oxoacyl-[acyl-carrier-protein] synthase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.41996 BP_3 45.30 0.64 3723 642919719 XP_008192036.1 895 4.0e-93 PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919721|ref|XP_008192037.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919723|ref|XP_008192039.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|270005423|gb|EFA01871.1| hypothetical protein TcasGA2_TC007476 [Tribolium castaneum] -- -- -- -- -- K17479 GRXCR1 glutaredoxin domain-containing cysteine-rich protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17479 Q9VNL4 538 4.1e-53 Glutaredoxin domain-containing cysteine-rich protein CG31559 OS=Drosophila melanogaster GN=CG31559 PE=1 SV=2 PF03334//PF00684//PF00462 Na+/H+ antiporter subunit//DnaJ central domain//Glutaredoxin GO:0006118//GO:0045454//GO:0015992//GO:0015672 obsolete electron transport//cell redox homeostasis//proton transport//monovalent inorganic cation transport GO:0051082//GO:0009055//GO:0015035//GO:0005451//GO:0031072 unfolded protein binding//electron carrier activity//protein disulfide oxidoreductase activity//monovalent cation:proton antiporter activity//heat shock protein binding -- -- KOG2824 Glutaredoxin-related protein Cluster-8309.420 BP_3 5.00 0.38 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03491 Serotonin (5-HT) neurotransmitter transporter, N-terminus GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005335 serotonin:sodium symporter activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.42003 BP_3 13.00 0.37 1970 642933218 XP_008197312.1 1186 3.8e-127 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O61369 762 2.3e-79 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.42004 BP_3 68.46 3.08 1363 332374670 AEE62476.1 724 9.9e-74 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9LZG0 383 1.4e-35 Adenosine kinase 2 OS=Arabidopsis thaliana GN=ADK2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.42005 BP_3 207.77 3.01 3620 270297180 NP_001161912.1 858 7.6e-89 cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|268309002|gb|ACY95467.1| cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|270001714|gb|EEZ98161.1| hypothetical protein TcasGA2_TC000587 [Tribolium castaneum] 817213894 XM_012427772.1 132 6.87143e-60 PREDICTED: Orussus abietinus uncharacterized LOC105701218 (LOC105701218), mRNA -- -- -- -- -- -- -- -- PF01607//PF02975 Chitin binding Peritrophin-A domain//Methylamine dehydrogenase, L chain GO:0009308//GO:0055114//GO:0006030 amine metabolic process//oxidation-reduction process//chitin metabolic process GO:0016638//GO:0008061 oxidoreductase activity, acting on the CH-NH2 group of donors//chitin binding GO:0042597//GO:0005576 periplasmic space//extracellular region -- -- Cluster-8309.42006 BP_3 1585.00 23.95 3482 571568658 XP_006565113.1 332 7.2e-28 PREDICTED: optineurin isoform X2 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88522 187 1.9e-12 NF-kappa-B essential modulator OS=Mus musculus GN=Ikbkg PE=1 SV=2 PF00096//PF10186//PF13851//PF08287//PF02183//PF06160//PF13912//PF07651 Zinc finger, C2H2 type//Vacuolar sorting 38 and autophagy-related subunit 14//Growth-arrest specific micro-tubule binding//Spc19//Homeobox associated leucine zipper//Septation ring formation regulator, EzrA//C2H2-type zinc finger//ANTH domain GO:0010508//GO:0006355//GO:0008608//GO:0000921//GO:0048870 positive regulation of autophagy//regulation of transcription, DNA-templated//attachment of spindle microtubules to kinetochore//septin ring assembly//cell motility GO:0046872//GO:0003700//GO:0043565//GO:0005543 metal ion binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//phospholipid binding GO:0005876//GO:0042729//GO:0005940//GO:0005667//GO:0031514//GO:0016021 spindle microtubule//DASH complex//septin ring//transcription factor complex//motile cilium//integral component of membrane -- -- Cluster-8309.42007 BP_3 57.20 0.61 4819 642931607 XP_008196654.1 1352 5.3e-146 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 170039524 XM_001847530.1 369 0 Culex quinquefasciatus eukaryotic translation initiation factor 2C 2, mRNA K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q6QME8 1122 1.0e-120 Protein argonaute-2 OS=Bos taurus GN=AGO2 PE=2 SV=1 PF02171//PF04810 Piwi domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.42009 BP_3 42.18 0.78 2905 642938243 XP_008198126.1 655 2.1e-65 PREDICTED: serine/threonine-protein kinase Doa isoform X1 [Tribolium castaneum] -- -- -- -- -- K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 494 4.0e-48 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF10399 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal GO:0055114//GO:0006119//GO:0015992//GO:0006118 oxidation-reduction process//oxidative phosphorylation//proton transport//obsolete electron transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- KOG0671 LAMMER dual specificity kinases Cluster-8309.42010 BP_3 163.94 14.82 825 642938247 XP_008198128.1 529 2.4e-51 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 58 2.07731e-19 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 176 8.6e-12 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0671 LAMMER dual specificity kinases Cluster-8309.42011 BP_3 939.69 55.76 1104 91081585 XP_975324.1 393 1.9e-35 PREDICTED: protein FAM177A1 [Tribolium castaneum]>gi|270005105|gb|EFA01553.1| hypothetical protein TcasGA2_TC007114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QLZ5 227 1.4e-17 Protein FAM177A1 OS=Bos taurus GN=FAM177A1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42012 BP_3 126.00 3.18 2204 270013588 EFA10036.1 161 3.1e-08 hypothetical protein TcasGA2_TC012208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02792 Mago nashi protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.42013 BP_3 55.88 0.44 6434 91094261 XP_969516.1 1804 2.7e-198 PREDICTED: tonsoku-like protein isoform X1 [Tribolium castaneum]>gi|270016258|gb|EFA12704.1| hypothetical protein TcasGA2_TC002338 [Tribolium castaneum] -- -- -- -- -- K09257 NFKBIL2 NF-kappa-B inhibitor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09257 Q9VSA4 748 3.2e-77 Tonsoku-like protein OS=Drosophila melanogaster GN=CG7457 PE=1 SV=1 PF13606//PF13181//PF08463//PF13855//PF13174//PF00515//PF13374//PF02827//PF00023//PF00560//PF13176//PF13414 Ankyrin repeat//Tetratricopeptide repeat//EcoEI R protein C-terminal//Leucine rich repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Ankyrin repeat//Leucine Rich Repeat//Tetratricopeptide repeat//TPR repeat GO:0045859//GO:0006469//GO:0006304 regulation of protein kinase activity//negative regulation of protein kinase activity//DNA modification GO:0005515//GO:0004862//GO:0003677//GO:0003824 protein binding//cAMP-dependent protein kinase inhibitor activity//DNA binding//catalytic activity GO:0005952 cAMP-dependent protein kinase complex KOG4177 Ankyrin Cluster-8309.42014 BP_3 236.36 2.23 5399 642937831 XP_008200319.1 4126 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1078 1.4e-115 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF00397//PF13180//PF00595 WW domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.42015 BP_3 1384.46 15.81 4512 478262128 ENN81013.1 2054 2.0e-227 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 529 5.5e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 PF11770//PF07926//PF00498 GRB2-binding adapter (GAPT)//TPR/MLP1/MLP2-like protein//FHA domain GO:0006606 protein import into nucleus GO:0005515 protein binding GO:0016021 integral component of membrane KOG0245 Kinesin-like protein Cluster-8309.42016 BP_3 28.59 1.56 1175 328698759 XP_003240725.1 137 9.9e-06 PREDICTED: serine/arginine repetitive matrix protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42017 BP_3 1.00 4.43 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42018 BP_3 400.61 11.11 2030 642930948 XP_008196153.1 1518 1.3e-165 PREDICTED: protein diaphanous isoform X3 [Tribolium castaneum] 642930947 XM_008197931.1 56 6.77525e-18 PREDICTED: Tribolium castaneum protein diaphanous (LOC660495), transcript variant X3, mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 771 2.1e-80 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF06371//PF06367//PF10508 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain//Proteasome non-ATPase 26S subunit GO:0030036//GO:0016043//GO:0043248 actin cytoskeleton organization//cellular component organization//proteasome assembly GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- KOG2691 RNA polymerase II subunit 9 Cluster-8309.42019 BP_3 33.69 0.48 3690 459464997 AGG68862.1 1336 2.9e-144 eIF5-mimic protein [Tribolium castaneum] 462279218 APGK01058392.1 75 3.40074e-28 Dendroctonus ponderosae Seq01058402, whole genome shotgun sequence -- -- -- -- Q9VNE2 882 5.3e-93 Protein krasavietz OS=Drosophila melanogaster GN=kra PE=1 SV=1 PF00448 SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding -- -- KOG2297 Predicted translation factor, contains W2 domain Cluster-8309.42020 BP_3 87.62 0.75 5910 642931643 XP_008196669.1 765 7.5e-78 PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum]>gi|642931645|ref|XP_972490.2| PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum] -- -- -- -- -- K04701 CISH cytokine inducible SH2-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04701 O14508 228 5.8e-17 Suppressor of cytokine signaling 2 OS=Homo sapiens GN=SOCS2 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.42021 BP_3 83.24 0.65 6493 642918222 XP_008191418.1 4592 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 1 isoform X1 [Tribolium castaneum]>gi|270003291|gb|EEZ99738.1| hypothetical protein TcasGA2_TC002507 [Tribolium castaneum] 795022714 XM_012005302.1 542 0 PREDICTED: Vollenhovia emeryi transcription initiation factor TFIID subunit 1 (LOC105557903), mRNA K03125 TAF1 transcription initiation factor TFIID subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03125 P51123 3568 0.0e+00 Transcription initiation factor TFIID subunit 1 OS=Drosophila melanogaster GN=Taf1 PE=1 SV=3 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG0008 Transcription initiation factor TFIID, subunit TAF1 Cluster-8309.42022 BP_3 53.00 4.30 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115 SFI toxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.42023 BP_3 54.19 0.85 3374 91093076 XP_968784.1 903 4.3e-94 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] 195036913 XM_001989877.1 35 5.34771e-06 Drosophila grimshawi GH18533 (Dgri\GH18533), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 844 1.2e-88 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42024 BP_3 216.88 10.17 1320 642926079 XP_008194755.1 840 3.4e-87 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 522 1.0e-51 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF00106//PF04406//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//Type IIB DNA topoisomerase//NAD dependent epimerase/dehydratase family GO:0006259//GO:0055114//GO:0008152 DNA metabolic process//oxidation-reduction process//metabolic process GO:0003677//GO:0050662//GO:0003824//GO:0005524//GO:0016491 DNA binding//coenzyme binding//catalytic activity//ATP binding//oxidoreductase activity GO:0005694 chromosome -- -- Cluster-8309.42025 BP_3 2341.23 33.50 3660 91086687 XP_969129.1 2459 1.7e-274 PREDICTED: tyrosine-protein kinase Src42A isoform X2 [Tribolium castaneum] 242015483 XM_002428338.1 244 3.81426e-122 Pediculus humanus corporis tyrosine-protein kinase Src42A, putative, mRNA K08892 FRK, PTK5 fyn-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08892 Q9V9J3 2167 5.2e-242 Tyrosine-protein kinase Src42A OS=Drosophila melanogaster GN=Src42A PE=2 SV=1 PF07714//PF00018//PF14604//PF00069//PF06293 Protein tyrosine kinase//SH3 domain//Variant SH3 domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524//GO:0016773 protein kinase activity//protein binding//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0197 Tyrosine kinases Cluster-8309.42026 BP_3 803.82 8.79 4698 642928846 XP_008195586.1 2003 1.7e-221 PREDICTED: tyrosine-protein kinase Src42A isoform X1 [Tribolium castaneum] 242015483 XM_002428338.1 244 4.90675e-122 Pediculus humanus corporis tyrosine-protein kinase Src42A, putative, mRNA K08892 FRK, PTK5 fyn-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08892 Q9V9J3 1803 1.1e-199 Tyrosine-protein kinase Src42A OS=Drosophila melanogaster GN=Src42A PE=2 SV=1 PF07714//PF00069//PF02043 Protein tyrosine kinase//Protein kinase domain//Bacteriochlorophyll C binding protein GO:0006468//GO:0015979 protein phosphorylation//photosynthesis GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0197 Tyrosine kinases Cluster-8309.42027 BP_3 31.67 5.93 549 478258333 ENN78452.1 570 2.9e-56 hypothetical protein YQE_05090, partial [Dendroctonus ponderosae]>gi|546677055|gb|ERL87964.1| hypothetical protein D910_05352 [Dendroctonus ponderosae] 806777497 KP219380.1 68 3.7339e-25 Paroster nigroadumbratus long-wavelength opsin (lwop) mRNA, partial cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 P35362 480 3.2e-47 Rhodopsin OS=Sphodromantis sp. PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.4203 BP_3 9.00 2.88 442 674304042 AIL23552.1 216 2.6e-15 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q2NL00 147 1.1e-08 Glutathione S-transferase theta-1 OS=Bos taurus GN=GSTT1 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42030 BP_3 3.96 1.06 471 642935298 XP_008197956.1 191 2.2e-12 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42031 BP_3 228.97 2.05 5679 642935312 XP_008197963.1 2061 3.8e-228 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 1.15303e-14 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1122 1.2e-120 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF10186//PF08702//PF00038 Vacuolar sorting 38 and autophagy-related subunit 14//Fibrinogen alpha/beta chain family//Intermediate filament protein GO:0051258//GO:0007165//GO:0010508//GO:0030168 protein polymerization//signal transduction//positive regulation of autophagy//platelet activation GO:0005198//GO:0005102//GO:0030674 structural molecule activity//receptor binding//protein binding, bridging GO:0005882//GO:0005577 intermediate filament//fibrinogen complex -- -- Cluster-8309.42032 BP_3 1332.09 13.49 5050 642915668 XP_008190705.1 623 1.9e-61 PREDICTED: uncharacterized protein LOC103312270 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V7U0 151 4.2e-08 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.42035 BP_3 992.00 84.14 860 282158103 NP_001164095.1 1352 9.4e-147 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] 194745413 XM_001955147.1 254 2.40163e-128 Drosophila ananassae GF18634 (Dana\GF18634), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1115 1.2e-120 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003677//GO:0016787//GO:0003676 ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.42037 BP_3 115.74 1.35 4431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42038 BP_3 430.00 12.97 1890 780653482 XP_011691002.1 2477 7.3e-277 PREDICTED: tRNA-splicing ligase RtcB homolog [Wasmannia auropunctata] 752874085 XM_011256048.1 451 0 PREDICTED: Camponotus floridanus tRNA-splicing ligase RtcB homolog (LOC105250110), mRNA K14415 RTCB, rtcB tRNA-splicing ligase RtcB http://www.genome.jp/dbget-bin/www_bget?ko:K14415 Q9VIW7 2423 5.5e-272 tRNA-splicing ligase RtcB homolog OS=Drosophila melanogaster GN=CG9987 PE=2 SV=1 PF01139 tRNA-splicing ligase RtcB GO:0006396 RNA processing GO:0008452 RNA ligase activity -- -- KOG3833 Uncharacterized conserved protein, contains RtcB domain Cluster-8309.42039 BP_3 1008.71 15.95 3340 642934154 XP_008199630.1 1009 2.2e-106 PREDICTED: telomerase reverse transcriptase isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009 Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.42040 BP_3 11976.71 124.65 4923 332376376 AEE63328.1 726 2.1e-73 unknown [Dendroctonus ponderosae]>gi|546675031|gb|ERL86292.1| hypothetical protein D910_03700 [Dendroctonus ponderosae] -- -- -- -- -- K01493 comEB dCMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01493 P32321 580 7.3e-58 Deoxycytidylate deaminase OS=Homo sapiens GN=DCTD PE=1 SV=2 PF03261//PF00383 Cyclin-dependent kinase 5 activator protein//Cytidine and deoxycytidylate deaminase zinc-binding region GO:0045859 regulation of protein kinase activity GO:0008270//GO:0016534 zinc ion binding//cyclin-dependent protein kinase 5 activator activity GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex KOG3127 Deoxycytidylate deaminase Cluster-8309.42041 BP_3 13.00 5.71 400 189236433 XP_972706.2 152 6.1e-08 PREDICTED: nuclear transcription factor Y subunit alpha isoform X1 [Tribolium castaneum]>gi|270005402|gb|EFA01850.1| hypothetical protein TcasGA2_TC007453 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016602//GO:0005667 CCAAT-binding factor complex//transcription factor complex -- -- Cluster-8309.42046 BP_3 1187.87 6.81 8704 642924084 XP_008193999.1 5676 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X1 [Tribolium castaneum] 642924089 XM_008195780.1 744 0 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 12 (LOC656353), transcript variant X4, mRNA K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q86YW9 2448 3.2e-274 Mediator of RNA polymerase II transcription subunit 12-like protein OS=Homo sapiens GN=MED12L PE=1 SV=2 PF09497 Transcription mediator complex subunit Med12 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3598 Thyroid hormone receptor-associated protein complex, subunit TRAP230 Cluster-8309.42047 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42049 BP_3 493.69 2.95 8356 642913355 XP_008195386.1 6061 0.0e+00 PREDICTED: protein polybromo-1 [Tribolium castaneum] -- -- -- -- -- K11757 PBRM1, PB1 protein polybromo-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11757 Q86U86 1886 4.5e-209 Protein polybromo-1 OS=Homo sapiens GN=PBRM1 PE=1 SV=1 PF07728//PF07726//PF00158//PF00493//PF00004//PF00439//PF01426 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//Bromodomain//BAH domain GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0005515//GO:0008134//GO:0005524//GO:0003677//GO:0003682//GO:0016887 protein binding//transcription factor binding//ATP binding//DNA binding//chromatin binding//ATPase activity GO:0005667//GO:0000785 transcription factor complex//chromatin KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.4205 BP_3 11.00 0.51 1336 861611173 KMQ85248.1 412 1.5e-37 nuclease harbi1 [Lasius niger] -- -- -- -- -- -- -- -- -- Q96MB7 170 6.9e-11 Putative nuclease HARBI1 OS=Homo sapiens GN=HARBI1 PE=1 SV=1 PF02319//PF04827//PF01609 E2F/DP family winged-helix DNA-binding domain//Plant transposon protein//Transposase DDE domain GO:0006355//GO:0006313 regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803//GO:0003700 DNA binding//hydrolase activity, acting on ester bonds//transposase activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42050 BP_3 357.61 10.04 2008 642925384 XP_008194526.1 2481 2.7e-277 PREDICTED: LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [Tribolium castaneum] 241056114 XM_002407701.1 98 3.00911e-41 Ixodes scapularis transformation/transcription domain-associated protein, putative, mRNA K08874 TRRAP transformation/transcription domain-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08874 Q9Y4A5 1905 6.8e-212 Transformation/transcription domain-associated protein OS=Homo sapiens GN=TRRAP PE=1 SV=3 PF00454//PF02260 Phosphatidylinositol 3- and 4-kinase//FATC domain -- -- GO:0005515//GO:0016773 protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0889 Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily Cluster-8309.42051 BP_3 387.54 8.42 2510 91082353 XP_967422.1 3058 0.0e+00 PREDICTED: DNA replication licensing factor Mcm7 [Tribolium castaneum]>gi|270007172|gb|EFA03620.1| hypothetical protein TcasGA2_TC013713 [Tribolium castaneum] 780092378 XM_011675888.1 72 1.07203e-26 PREDICTED: Strongylocentrotus purpuratus DNA replication licensing factor mcm7-A (LOC574771), transcript variant X2, mRNA K02210 MCM7, CDC47 DNA replication licensing factor MCM7 http://www.genome.jp/dbget-bin/www_bget?ko:K02210 Q9XYU0 2687 1.8e-302 DNA replication licensing factor Mcm7 OS=Drosophila melanogaster GN=Mcm7 PE=1 SV=1 PF00493//PF00285//PF07728//PF07726 MCM2/3/5 family//Citrate synthase//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006270//GO:0006260 DNA replication initiation//DNA replication GO:0046912//GO:0003677//GO:0005524//GO:0017111//GO:0016887 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer//DNA binding//ATP binding//nucleoside-triphosphatase activity//ATPase activity GO:0005634 nucleus KOG0482 DNA replication licensing factor, MCM7 component Cluster-8309.42052 BP_3 680.70 49.92 949 91086581 XP_973438.1 1079 4.7e-115 PREDICTED: derlin-1 [Tribolium castaneum]>gi|270010357|gb|EFA06805.1| hypothetical protein TcasGA2_TC009744 [Tribolium castaneum] -- -- -- -- -- K11519 DERL1 Derlin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11519 Q5R9W3 805 1.1e-84 Derlin-1 OS=Pongo abelii GN=DERL1 PE=2 SV=1 PF04505//PF01694 Interferon-induced transmembrane protein//Rhomboid family GO:0009607 response to biotic stimulus GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG0858 Predicted membrane protein Cluster-8309.42054 BP_3 118.00 6.42 1178 270011709 EFA08157.1 164 7.4e-09 hypothetical protein TcasGA2_TC005777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10471 Anaphase-promoting complex APC subunit CDC26 GO:0030071//GO:0031145 regulation of mitotic metaphase/anaphase transition//anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process -- -- GO:0005680 anaphase-promoting complex -- -- Cluster-8309.42056 BP_3 25.87 0.43 3182 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42058 BP_3 528.77 10.70 2673 642913783 XP_008201159.1 2257 3.4e-251 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 8.83309e-28 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 2053 6.2e-229 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF10462//PF00413 Peptidase M66//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.42060 BP_3 18.54 0.31 3156 642913783 XP_008201159.1 2257 4.0e-251 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 1.04437e-27 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 2053 7.4e-229 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF05175//PF03602//PF00413//PF10462 Methyltransferase small domain//Conserved hypothetical protein 95//Matrixin//Peptidase M66 GO:0031167//GO:0006508 rRNA methylation//proteolysis GO:0008270//GO:0004222//GO:0008168 zinc ion binding//metalloendopeptidase activity//methyltransferase activity GO:0031012 extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.42062 BP_3 1509.68 15.43 5007 642910889 XP_008193451.1 4292 0.0e+00 PREDICTED: SLIT-ROBO Rho GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] 805778458 XM_012283126.1 285 8.45067e-145 PREDICTED: Megachile rotundata SLIT-ROBO Rho GTPase-activating protein 1 (LOC100883803), transcript variant X1, mRNA K07526 SRGAP SLIT-ROBO Rho GTPase activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K07526 Q7Z6B7 1641 6.9e-181 SLIT-ROBO Rho GTPase-activating protein 1 OS=Homo sapiens GN=SRGAP1 PE=1 SV=1 PF09177//PF14604//PF00620//PF00018//PF16740//PF02321 Syntaxin 6, N-terminal//Variant SH3 domain//RhoGAP domain//SH3 domain//Spindle and kinetochore-associated protein 2//Outer membrane efflux protein GO:0000090//GO:0007067//GO:0051301//GO:0031110//GO:0007059//GO:0007165//GO:0006810//GO:0048193 mitotic anaphase//mitotic nuclear division//cell division//regulation of microtubule polymerization or depolymerization//chromosome segregation//signal transduction//transport//Golgi vesicle transport GO:0008017//GO:0005215//GO:0005515 microtubule binding//transporter activity//protein binding GO:0016020//GO:0000940//GO:0005876//GO:0045298 membrane//condensed chromosome outer kinetochore//spindle microtubule//tubulin complex -- -- Cluster-8309.42064 BP_3 616.72 49.19 896 642927566 XP_972340.2 566 1.4e-55 PREDICTED: 40S ribosomal protein S12 [Tribolium castaneum] -- -- -- -- -- K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P80455 427 7.3e-41 40S ribosomal protein S12 OS=Drosophila melanogaster GN=RpS12 PE=1 SV=2 PF02065 Melibiase GO:0046486//GO:0005975//GO:0001575//GO:0006012 glycerolipid metabolic process//carbohydrate metabolic process//globoside metabolic process//galactose metabolic process GO:0004557 alpha-galactosidase activity -- -- KOG3406 40S ribosomal protein S12 Cluster-8309.42065 BP_3 56.28 1.21 2529 642919579 XP_008191929.1 297 6.0e-24 PREDICTED: heat shock 70 kDa protein 4 isoform X2 [Tribolium castaneum]>gi|270005857|gb|EFA02305.1| hypothetical protein TcasGA2_TC007971 [Tribolium castaneum] -- -- -- -- -- K09485 HSP110 heat shock protein 110kDa http://www.genome.jp/dbget-bin/www_bget?ko:K09485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42066 BP_3 268.48 7.99 1912 91088923 XP_973277.1 1071 8.0e-114 PREDICTED: lysophospholipid acyltransferase 7 [Tribolium castaneum] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 Q5U4T9 604 4.7e-61 Lysophospholipid acyltransferase 7 OS=Xenopus laevis GN=mboat7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2706 Predicted membrane protein Cluster-8309.42070 BP_3 7.20 0.61 858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42073 BP_3 20.91 0.37 3019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42074 BP_3 3521.70 74.21 2579 642919846 XP_008192093.1 650 7.1e-65 PREDICTED: lipid storage droplets surface-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 218 3.6e-16 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 PF05459 Herpesvirus transcriptional regulator family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.42075 BP_3 42.85 0.43 5048 189240845 XP_001812763.1 2784 0.0e+00 PREDICTED: AP-1 complex subunit gamma-1 isoform X1 [Tribolium castaneum] 393809286 JQ824200.1 361 0 Bombyx mori adaptor protein complex-1 gamma subunit (AP1G) mRNA, complete cds, alternatively spliced K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 1854 1.4e-205 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF02883//PF02985//PF03255//PF08367//PF01602 Adaptin C-terminal domain//HEAT repeat//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Peptidase M16C associated//Adaptin N terminal region GO:0006508//GO:0006090//GO:0016192//GO:0006886//GO:0006633 proteolysis//pyruvate metabolic process//vesicle-mediated transport//intracellular protein transport//fatty acid biosynthetic process GO:0003989//GO:0005515 acetyl-CoA carboxylase activity//protein binding GO:0030117//GO:0009317//GO:0030131 membrane coat//acetyl-CoA carboxylase complex//clathrin adaptor complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.42076 BP_3 62.59 0.97 3409 189240845 XP_001812763.1 3345 0.0e+00 PREDICTED: AP-1 complex subunit gamma-1 isoform X1 [Tribolium castaneum] 393809286 JQ824200.1 482 0 Bombyx mori adaptor protein complex-1 gamma subunit (AP1G) mRNA, complete cds, alternatively spliced K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 2321 6.7e-260 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF01602//PF02985//PF02883//PF08367 Adaptin N terminal region//HEAT repeat//Adaptin C-terminal domain//Peptidase M16C associated GO:0016192//GO:0006886//GO:0006508 vesicle-mediated transport//intracellular protein transport//proteolysis GO:0005515 protein binding GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.42078 BP_3 1251.78 13.58 4735 642926029 XP_969555.3 1934 1.7e-213 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 3.45329e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 2.9e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42080 BP_3 2661.88 15.62 8504 642911051 XP_008200619.1 8610 0.0e+00 PREDICTED: HEAT repeat-containing protein 5B isoform X1 [Tribolium castaneum] 549438536 KC282400.1 192 7.18548e-93 Leptinotarsa decemlineata clone 18-9298 disulfide-isomerase mRNA, partial cds -- -- -- -- Q9P2D3 5357 0.0e+00 HEAT repeat-containing protein 5B OS=Homo sapiens GN=HEATR5B PE=1 SV=2 PF00578//PF00514//PF00085//PF02985//PF08785 AhpC/TSA family//Armadillo/beta-catenin-like repeat//Thioredoxin//HEAT repeat//Ku C terminal domain like GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0005515//GO:0016491//GO:0016817 antioxidant activity//protein binding//oxidoreductase activity//hydrolase activity, acting on acid anhydrides -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.42082 BP_3 222.01 0.94 11703 91083299 XP_974608.1 2229 2.6e-247 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 2.9e-193 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 PF01695//PF06414//PF00004//PF06309//PF11057 IstB-like ATP binding protein//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Torsin//Cortexin of kidney -- -- GO:0016301//GO:0005524 kinase activity//ATP binding GO:0031224 intrinsic component of membrane KOG2558 Negative regulator of histones Cluster-8309.42085 BP_3 89.91 3.09 1696 642912938 XP_008201315.1 653 2.1e-65 PREDICTED: antichymotrypsin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22922 448 5.1e-43 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42086 BP_3 28.67 1.55 1184 264667459 ACY71315.1 524 1.3e-50 ribosomal protein L28 [Chrysomela tremula] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 427 9.7e-41 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-8309.42087 BP_3 42.17 1.38 1760 642912938 XP_008201315.1 653 2.2e-65 PREDICTED: antichymotrypsin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22922 448 5.3e-43 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42089 BP_3 214.98 1.57 6877 642911463 XP_008199434.1 1032 9.6e-109 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF03323//PF15220 MAP7 (E-MAP-115) family//Bacillus/Clostridium GerA spore germination protein//Hypoxia-inducible lipid droplet-associated GO:0001819//GO:0000226//GO:0010884//GO:0009847//GO:0008284 positive regulation of cytokine production//microtubule cytoskeleton organization//positive regulation of lipid storage//spore germination//positive regulation of cell proliferation -- -- GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane -- -- Cluster-8309.42091 BP_3 854.44 7.77 5589 478256475 ENN76660.1 630 3.2e-62 hypothetical protein YQE_06839, partial [Dendroctonus ponderosae] -- -- -- -- -- K12887 HNRNPM heterogeneous nuclear ribonucleoprotein M http://www.genome.jp/dbget-bin/www_bget?ko:K12887 Q9D0E1 281 3.9e-23 Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus GN=Hnrnpm PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4212 RNA-binding protein hnRNP-M Cluster-8309.42093 BP_3 37.48 0.51 3814 270014029 EFA10477.1 699 2.2e-70 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 1.27361e-22 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- Q5R6A9 173 8.9e-11 TOX high mobility group box family member 4 OS=Pongo abelii GN=TOX4 PE=2 SV=2 PF03460//PF11770 Nitrite/Sulfite reductase ferredoxin-like half domain//GRB2-binding adapter (GAPT) GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.42095 BP_3 78.54 0.53 7385 642912341 XP_008199603.1 2324 1.6e-258 PREDICTED: DNA polymerase delta catalytic subunit [Tribolium castaneum]>gi|270002921|gb|EEZ99368.1| DNA polymerase delta [Tribolium castaneum] 324120713 AB598708.1 168 1.36906e-79 Euconocephalus varius DPD1 mRNA for DNA polymerase delta catalytic subunit, complete cds, isolate: 7 K02327 POLD1 DNA polymerase delta subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02327 P54358 1662 3.8e-183 DNA polymerase delta catalytic subunit OS=Drosophila melanogaster GN=DNApol-delta PE=2 SV=2 PF03104//PF05225//PF03184//PF03175//PF00136 DNA polymerase family B, exonuclease domain//helix-turn-helix, Psq domain//DDE superfamily endonuclease//DNA polymerase type B, organellar and viral//DNA polymerase family B GO:0006260 DNA replication GO:0003676//GO:0008408//GO:0003677//GO:0000166//GO:0003887 nucleic acid binding//3'-5' exonuclease activity//DNA binding//nucleotide binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG0969 DNA polymerase delta, catalytic subunit Cluster-8309.42097 BP_3 71.08 0.67 5399 478255296 ENN75522.1 1701 2.0e-186 hypothetical protein YQE_07866, partial [Dendroctonus ponderosae]>gi|546683150|gb|ERL93001.1| hypothetical protein D910_10303 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 583 3.6e-58 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 PF01278 Omptin family GO:0006508 proteolysis GO:0004175 endopeptidase activity GO:0009279 cell outer membrane KOG1304 Amino acid transporters Cluster-8309.42100 BP_3 47.61 0.43 5628 478255117 ENN75347.1 1050 6.4e-111 hypothetical protein YQE_08123, partial [Dendroctonus ponderosae] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 O01735 608 4.7e-61 Uncharacterized MFS-type transporter C09D4.1 OS=Caenorhabditis elegans GN=C09D4.1 PE=3 SV=2 PF10640//PF07690 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase//Major Facilitator Superfamily GO:0006370//GO:0055085 7-methylguanosine mRNA capping//transmembrane transport GO:0004484//GO:0004651 mRNA guanylyltransferase activity//polynucleotide 5'-phosphatase activity GO:0016021 integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.42103 BP_3 136.82 3.59 2130 91092778 XP_973837.1 667 6.3e-67 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.42104 BP_3 1199.69 6.29 9486 642922507 XP_008193202.1 10522 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X1 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.42708e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1894 6.1e-210 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF11547//PF04625//PF00632//PF00658 E3 ubiquitin ligase EDD//DEC-1 protein, N-terminal region//HECT-domain (ubiquitin-transferase)//Poly-adenylate binding protein, unique domain GO:0007304//GO:0016567 chorion-containing eggshell formation//protein ubiquitination GO:0004842//GO:0003723//GO:0005213//GO:0043130 ubiquitin-protein transferase activity//RNA binding//structural constituent of chorion//ubiquitin binding GO:0042600//GO:0005576 chorion//extracellular region KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.42107 BP_3 68.18 2.31 1717 642937622 XP_008199126.1 1008 1.5e-106 PREDICTED: probable cytochrome P450 6a13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q964R1 773 1.1e-80 Cytochrome P450 6j1 OS=Blattella germanica GN=CYP6J1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.42108 BP_3 693.45 4.88 7140 642928768 XP_008195553.1 4946 0.0e+00 PREDICTED: ATPase, class II, type 9B isoform X2 [Tribolium castaneum] 342356458 JF265057.1 79 3.94932e-30 Heliconius melpomene cythera ribosomal protein L29 (RpL29) mRNA, complete cds K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3572 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF12861//PF07926//PF17123//PF12678//PF07851//PF00628//PF14634//PF11365//PF00769//PF13639//PF15898//PF16685//PF01166//PF10473//PF00122//PF01779//PF00097 Anaphase-promoting complex subunit 11 RING-H2 finger//TPR/MLP1/MLP2-like protein//RING-like zinc finger//RING-H2 zinc finger//TMPIT-like protein//PHD-finger//zinc-RING finger domain//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Ring finger domain//cGMP-dependent protein kinase interacting domain//zinc RING finger of MSL2//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//E1-E2 ATPase//Ribosomal L29e protein family//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0006412//GO:0010506//GO:0042254//GO:0006355//GO:0006606 protein ubiquitination//translation//regulation of autophagy//ribosome biogenesis//regulation of transcription, DNA-templated//protein import into nucleus GO:0004842//GO:0061630//GO:0005515//GO:0008092//GO:0046872//GO:0042803//GO:0045502//GO:0008134//GO:0003700//GO:0000166//GO:0008270//GO:0003735//GO:0019901 ubiquitin-protein transferase activity//ubiquitin protein ligase activity//protein binding//cytoskeletal protein binding//metal ion binding//protein homodimerization activity//dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//nucleotide binding//zinc ion binding//structural constituent of ribosome//protein kinase binding GO:0005667//GO:0005680//GO:0030286//GO:0016021//GO:0019898//GO:0005615//GO:0005737//GO:0005840//GO:0005622 transcription factor complex//anaphase-promoting complex//dynein complex//integral component of membrane//extrinsic component of membrane//extracellular space//cytoplasm//ribosome//intracellular KOG0210 P-type ATPase Cluster-8309.42109 BP_3 50.65 0.39 6548 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.33941e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.3e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF01929//PF00787//PF14604//PF00018//PF00620 Ribosomal protein L14//PX domain//Variant SH3 domain//SH3 domain//RhoGAP domain GO:0042254//GO:0007154//GO:0007165//GO:0006412 ribosome biogenesis//cell communication//signal transduction//translation GO:0003735//GO:0035091//GO:0005515 structural constituent of ribosome//phosphatidylinositol binding//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.42111 BP_3 76.03 2.31 1877 642910471 XP_008200227.1 1010 9.3e-107 PREDICTED: uncharacterized protein LOC659133 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZR8 242 4.4e-19 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.42112 BP_3 2431.20 11.05 10892 642930447 XP_008196405.1 785 6.7e-80 PREDICTED: synaptosomal-associated protein 25 isoform X4 [Tribolium castaneum]>gi|270010729|gb|EFA07177.1| hypothetical protein TcasGA2_TC010177 [Tribolium castaneum] 642930446 XM_008198183.1 269 1.44641e-135 PREDICTED: Tribolium castaneum synaptosomal-associated protein 25 (LOC663588), transcript variant X4, mRNA K18211 SNAP25 synaptosomal-associated protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K18211 P36975 708 2.3e-72 Synaptosomal-associated protein 25 OS=Drosophila melanogaster GN=Snap25 PE=2 SV=1 PF01292//PF03419 Prokaryotic cytochrome b561//Sporulation factor SpoIIGA GO:0030436//GO:0006118//GO:0006508 asexual sporulation//obsolete electron transport//proteolysis GO:0009055//GO:0004190 electron carrier activity//aspartic-type endopeptidase activity GO:0043005//GO:0016021 neuron projection//integral component of membrane KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.42114 BP_3 83.40 1.82 2501 642915736 XP_008190782.1 3313 0.0e+00 PREDICTED: kalirin isoform X2 [Tribolium castaneum] 642915735 XM_008192560.1 732 0 PREDICTED: Tribolium castaneum kalirin (LOC656919), transcript variant X2, mRNA K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 Q0KL02 1705 1.3e-188 Triple functional domain protein OS=Mus musculus GN=Trio PE=1 SV=3 PF00435//PF11896//PF09589//PF10484 Spectrin repeat//Domain of unknown function (DUF3416)//HrpA pilus formation protein//Mitochondrial ribosomal protein S23 GO:0005975//GO:0042254//GO:0006412//GO:0009405 carbohydrate metabolic process//ribosome biogenesis//translation//pathogenesis GO:0003735//GO:0005515//GO:0004553 structural constituent of ribosome//protein binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005615//GO:0005840 extracellular space//ribosome KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.42116 BP_3 236.33 3.63 3431 642936574 XP_008198491.1 1031 6.3e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 3.0e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF10590//PF01243//PF12766//PF08241//PF05175//PF02252//PF03602//PF02251 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Methyltransferase domain//Methyltransferase small domain//Proteasome activator pa28 beta subunit//Conserved hypothetical protein 95//Proteasome activator pa28 alpha subunit GO:0031167//GO:0008152//GO:0055114//GO:0008615 rRNA methylation//metabolic process//oxidation-reduction process//pyridoxine biosynthetic process GO:0004733//GO:0010181//GO:0016638//GO:0008168 pyridoxamine-phosphate oxidase activity//FMN binding//oxidoreductase activity, acting on the CH-NH2 group of donors//methyltransferase activity GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.42117 BP_3 1554.23 42.75 2044 642936574 XP_008198491.1 1031 3.7e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 1.8e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF02252//PF01243//PF12766//PF02251 Proteasome activator pa28 beta subunit//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Proteasome activator pa28 alpha subunit GO:0055114//GO:0008615 oxidation-reduction process//pyridoxine biosynthetic process GO:0004733//GO:0010181 pyridoxamine-phosphate oxidase activity//FMN binding GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.42120 BP_3 241.98 5.13 2566 91078780 XP_969394.1 1583 4.6e-173 PREDICTED: nedd8-activating enzyme E1 regulatory subunit [Tribolium castaneum]>gi|270004104|gb|EFA00552.1| hypothetical protein TcasGA2_TC003419 [Tribolium castaneum] -- -- -- -- -- K04532 APPBP1 amyloid beta precursor protein binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04532 Q7SXP2 892 2.5e-94 NEDD8-activating enzyme E1 regulatory subunit OS=Danio rerio GN=nae1 PE=2 SV=2 PF05104//PF01210//PF08041//PF00125//PF08036//PF13413 Ribosome receptor lysine/proline rich region//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//PetM family of cytochrome b6f complex subunit 7//Core histone H2A/H2B/H3/H4//Diapausin family of antimicrobial peptide//Helix-turn-helix domain GO:0015031//GO:0055114//GO:0046168//GO:0008152//GO:0050832 protein transport//oxidation-reduction process//glycerol-3-phosphate catabolic process//metabolic process//defense response to fungus GO:0000166//GO:0003677//GO:0003824//GO:0051287//GO:0016616 nucleotide binding//DNA binding//catalytic activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005576//GO:0030176//GO:0009512 extracellular region//integral component of endoplasmic reticulum membrane//cytochrome b6f complex KOG2016 NEDD8-activating complex, APP-BP1/UBA5 component Cluster-8309.42121 BP_3 3.00 4.85 306 91078780 XP_969394.1 435 7.1e-41 PREDICTED: nedd8-activating enzyme E1 regulatory subunit [Tribolium castaneum]>gi|270004104|gb|EFA00552.1| hypothetical protein TcasGA2_TC003419 [Tribolium castaneum] -- -- -- -- -- K04532 APPBP1 amyloid beta precursor protein binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04532 Q5ZIE6 319 8.3e-29 NEDD8-activating enzyme E1 regulatory subunit OS=Gallus gallus GN=NAE1 PE=2 SV=1 PF00899 ThiF family GO:0008152 metabolic process GO:0008641//GO:0000166//GO:0003824 small protein activating enzyme activity//nucleotide binding//catalytic activity -- -- KOG2016 NEDD8-activating complex, APP-BP1/UBA5 component Cluster-8309.42124 BP_3 331.42 12.06 1616 642910507 XP_008200244.1 1345 1.1e-145 PREDICTED: uncharacterized protein LOC660017 [Tribolium castaneum] 462373318 APGK01024789.1 75 1.47188e-28 Dendroctonus ponderosae Seq01024799, whole genome shotgun sequence K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 Q5FW38 243 2.9e-19 Nuclear factor interleukin-3-regulated protein OS=Xenopus tropicalis GN=nfil3 PE=2 SV=1 PF00170//PF07716//PF03131 bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.42125 BP_3 98.79 4.42 1368 642910507 XP_008200244.1 1392 3.4e-151 PREDICTED: uncharacterized protein LOC660017 [Tribolium castaneum] 462373318 APGK01024789.1 75 1.241e-28 Dendroctonus ponderosae Seq01024799, whole genome shotgun sequence K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 Q5FW38 243 2.4e-19 Nuclear factor interleukin-3-regulated protein OS=Xenopus tropicalis GN=nfil3 PE=2 SV=1 PF07716//PF00170//PF03131 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.42127 BP_3 69.69 0.42 8341 642929719 XP_008195949.1 2566 1.5e-286 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.89609e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q28653 2003 1.2e-222 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Oryctolagus cuniculus GN=PPP2R5D PE=2 SV=1 PF00910//PF00515//PF00004//PF01695//PF07728//PF05496//PF01603//PF06068 RNA helicase//Tetratricopeptide repeat//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//TIP49 C-terminus GO:0006310//GO:0007165//GO:0006281 DNA recombination//signal transduction//DNA repair GO:0016887//GO:0009378//GO:0003724//GO:0008601//GO:0005524//GO:0003678//GO:0003723//GO:0005515 ATPase activity//four-way junction helicase activity//RNA helicase activity//protein phosphatase type 2A regulator activity//ATP binding//DNA helicase activity//RNA binding//protein binding GO:0000159//GO:0009379//GO:0005657 protein phosphatase type 2A complex//Holliday junction helicase complex//replication fork KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.42129 BP_3 676.67 3.67 9171 642915923 XP_008190812.1 5097 0.0e+00 PREDICTED: protein retinal degeneration B isoform X4 [Tribolium castaneum] 642915922 XM_008192590.1 835 0 PREDICTED: Tribolium castaneum protein retinal degeneration B (LOC655106), transcript variant X6, mRNA -- -- -- -- P43125 3461 0.0e+00 Protein retinal degeneration B OS=Drosophila melanogaster GN=rdgB PE=1 SV=2 PF13895//PF03767//PF00041//PF16656//PF02480//PF02862//PF02121 Immunoglobulin domain//HAD superfamily, subfamily IIIB (Acid phosphatase)//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//DDHD domain//Phosphatidylinositol transfer protein GO:0006771//GO:0019497//GO:0006810 riboflavin metabolic process//hexachlorocyclohexane metabolic process//transport GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.42130 BP_3 1228.87 14.08 4499 91094823 XP_971065.1 3140 0.0e+00 PREDICTED: protein O-mannosyltransferase 1 [Tribolium castaneum] 847169839 XM_002938748.3 97 2.44736e-40 PREDICTED: Xenopus (Silurana) tropicalis proteasome (prosome, macropain) subunit, beta type, 7 (psmb7), mRNA K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q9VTK2 2264 3.6e-253 Protein O-mannosyltransferase 1 OS=Drosophila melanogaster GN=rt PE=2 SV=2 PF02815//PF02366//PF00227 MIR domain//Dolichyl-phosphate-mannose-protein mannosyltransferase//Proteasome subunit GO:0006493//GO:0051603 protein O-linked glycosylation//proteolysis involved in cellular protein catabolic process GO:0000030//GO:0004298 mannosyltransferase activity//threonine-type endopeptidase activity GO:0016020//GO:0005839//GO:0000136 membrane//proteasome core complex//alpha-1,6-mannosyltransferase complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.42131 BP_3 204.30 1.54 6702 642912146 XP_008200825.1 1113 3.8e-118 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNM6 504 6.5e-49 Protein FAM102A OS=Xenopus laevis GN=fam102a PE=2 SV=1 PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.42132 BP_3 2870.74 22.79 6362 189239475 XP_975363.2 2302 4.8e-256 PREDICTED: atlastin [Tribolium castaneum]>gi|270010557|gb|EFA07005.1| hypothetical protein TcasGA2_TC009975 [Tribolium castaneum] 462343538 APGK01035351.1 39 6.05366e-08 Dendroctonus ponderosae Seq01035361, whole genome shotgun sequence K17339 ATL atlastin http://www.genome.jp/dbget-bin/www_bget?ko:K17339 Q9VC57 1767 2.2e-195 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 PF13176//PF02263//PF13414//PF00515//PF00106//PF02841//PF13174//PF00056//PF12242//PF02882//PF13181//PF07475//PF01370 Tetratricopeptide repeat//Guanylate-binding protein, N-terminal domain//TPR repeat//Tetratricopeptide repeat//short chain dehydrogenase//Guanylate-binding protein, C-terminal domain//Tetratricopeptide repeat//lactate/malate dehydrogenase, NAD binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Tetratricopeptide repeat//HPr Serine kinase C-terminal domain//NAD dependent epimerase/dehydratase family GO:0000160//GO:0046487//GO:0006109//GO:0009396//GO:0055114//GO:0008152//GO:0016310//GO:0006184 phosphorelay signal transduction system//glyoxylate metabolic process//regulation of carbohydrate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process//metabolic process//phosphorylation//obsolete GTP catabolic process GO:0000155//GO:0005524//GO:0050662//GO:0003924//GO:0004488//GO:0003824//GO:0005515//GO:0016491//GO:0005525//GO:0004672 phosphorelay sensor kinase activity//ATP binding//coenzyme binding//GTPase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//protein binding//oxidoreductase activity//GTP binding//protein kinase activity GO:0009365 protein histidine kinase complex KOG2037 Guanylate-binding protein Cluster-8309.42133 BP_3 749.61 6.03 6283 189239475 XP_975363.2 2302 4.8e-256 PREDICTED: atlastin [Tribolium castaneum]>gi|270010557|gb|EFA07005.1| hypothetical protein TcasGA2_TC009975 [Tribolium castaneum] 462343538 APGK01035351.1 39 5.97805e-08 Dendroctonus ponderosae Seq01035361, whole genome shotgun sequence K17339 ATL atlastin http://www.genome.jp/dbget-bin/www_bget?ko:K17339 Q9VC57 1767 2.1e-195 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 PF13414//PF02263//PF13174//PF13176//PF02841//PF00515//PF13181 TPR repeat//Guanylate-binding protein, N-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Guanylate-binding protein, C-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006184 obsolete GTP catabolic process GO:0005515//GO:0003924//GO:0005525 protein binding//GTPase activity//GTP binding -- -- KOG2037 Guanylate-binding protein Cluster-8309.42134 BP_3 226.70 6.11 2081 189235662 XP_001811794.1 1463 3.1e-159 PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum]>gi|642917553|ref|XP_008191254.1| PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42135 BP_3 80.77 0.86 4807 91092640 XP_969145.1 2864 0.0e+00 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1246 4.2e-135 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 PF00628 PHD-finger -- -- GO:0043169//GO:0005515 cation binding//protein binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.42136 BP_3 11.59 0.33 1984 478252606 ENN73011.1 995 5.4e-105 hypothetical protein YQE_10346, partial [Dendroctonus ponderosae]>gi|546677977|gb|ERL88706.1| hypothetical protein D910_06088 [Dendroctonus ponderosae] 755890983 XM_005189166.2 182 5.99488e-88 PREDICTED: Musca domestica cdc42 homolog (LOC101898849), transcript variant X2, mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 Q17031 953 1.7e-101 Cdc42 homolog OS=Anopheles gambiae GN=Cdc42 PE=2 SV=2 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.42137 BP_3 28.20 1.39 1271 478252606 ENN73011.1 751 6.8e-77 hypothetical protein YQE_10346, partial [Dendroctonus ponderosae]>gi|546677977|gb|ERL88706.1| hypothetical protein D910_06088 [Dendroctonus ponderosae] 704163529 XM_010146261.1 149 8.40593e-70 PREDICTED: Buceros rhinoceros silvestris cell division cycle 42 (CDC42), transcript variant X2, mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 Q17031 730 7.6e-76 Cdc42 homolog OS=Anopheles gambiae GN=Cdc42 PE=2 SV=2 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.42138 BP_3 9.40 0.37 1524 478252606 ENN73011.1 250 1.0e-18 hypothetical protein YQE_10346, partial [Dendroctonus ponderosae]>gi|546677977|gb|ERL88706.1| hypothetical protein D910_06088 [Dendroctonus ponderosae] 195456825 XM_002075268.1 69 3.00066e-25 Drosophila willistoni GK17312 (Dwil\GK17312), mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 Q29HY3 229 1.1e-17 Cdc42 homolog OS=Drosophila pseudoobscura pseudoobscura GN=Cdc42 PE=3 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.42139 BP_3 41.24 10.33 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42140 BP_3 129.75 1.86 3655 390362249 XP_001190749.2 463 4.9e-43 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q9ERK0 350 2.5e-31 Receptor-interacting serine/threonine-protein kinase 4 OS=Mus musculus GN=Ripk4 PE=1 SV=2 PF00931//PF13606//PF00023 NB-ARC domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0043531//GO:0005515 ADP binding//protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.42141 BP_3 51.25 0.75 3586 390362249 XP_001190749.2 463 4.8e-43 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q9ERK0 350 2.5e-31 Receptor-interacting serine/threonine-protein kinase 4 OS=Mus musculus GN=Ripk4 PE=1 SV=2 PF00931//PF13606//PF00023 NB-ARC domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0043531//GO:0005515 ADP binding//protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.42142 BP_3 223.03 2.78 4161 642930410 XP_008196388.1 3749 0.0e+00 PREDICTED: presequence protease, mitochondrial [Tribolium castaneum]>gi|270010721|gb|EFA07169.1| hypothetical protein TcasGA2_TC010168 [Tribolium castaneum] -- -- -- -- -- K06972 K06972 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06972 Q9V9E3 2309 2.0e-258 Presequence protease, mitochondrial OS=Drosophila melanogaster GN=CG3107 PE=2 SV=2 PF08397//PF08367 IRSp53/MIM homology domain//Peptidase M16C associated GO:0007009//GO:0006508 plasma membrane organization//proteolysis GO:0046872//GO:0008270//GO:0004222 metal ion binding//zinc ion binding//metalloendopeptidase activity -- -- KOG2019 Metalloendoprotease HMP1 (insulinase superfamily) Cluster-8309.42144 BP_3 333.63 12.39 1590 189239803 XP_970743.2 1019 7.1e-108 PREDICTED: TRAF-type zinc finger domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R970 128 6.1e-06 TRAF-type zinc finger domain-containing protein 1 OS=Macaca fascicularis GN=TRAFD1 PE=2 SV=1 PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.42145 BP_3 196.00 5.05 2161 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01293 Phosphoenolpyruvate carboxykinase GO:0006094//GO:0015976//GO:0006099 gluconeogenesis//carbon utilization//tricarboxylic acid cycle GO:0004612//GO:0005524 phosphoenolpyruvate carboxykinase (ATP) activity//ATP binding -- -- -- -- Cluster-8309.42147 BP_3 47.17 0.49 4933 642923556 XP_008193558.1 1060 3.9e-112 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270006985|gb|EFA03433.1| hypothetical protein TcasGA2_TC013423 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH60 226 8.2e-17 Golgi-associated PDZ and coiled-coil motif-containing protein OS=Mus musculus GN=Gopc PE=1 SV=1 PF07464 Apolipophorin-III precursor (apoLp-III) GO:0006869 lipid transport GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.42150 BP_3 43.00 0.68 3344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42155 BP_3 1218.00 34.11 2013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42157 BP_3 835.73 10.07 4290 642920003 XP_008192163.1 334 5.2e-28 PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum]>gi|642920005|ref|XP_008192164.1| PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42160 BP_3 110.05 0.85 6530 91084043 XP_967085.1 1345 4.6e-145 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 157 1.57603e-73 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1123 1.1e-120 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF01336//PF10415//PF01607//PF01029//PF00491 OB-fold nucleic acid binding domain//Fumarase C C-terminus//Chitin binding Peritrophin-A domain//NusB family//Arginase family GO:0019643//GO:0006030//GO:0006106//GO:0006355//GO:0006099 reductive tricarboxylic acid cycle//chitin metabolic process//fumarate metabolic process//regulation of transcription, DNA-templated//tricarboxylic acid cycle GO:0003723//GO:0046872//GO:0016829//GO:0004333//GO:0008061//GO:0003676 RNA binding//metal ion binding//lyase activity//fumarate hydratase activity//chitin binding//nucleic acid binding GO:0045239//GO:0005576 tricarboxylic acid cycle enzyme complex//extracellular region KOG1317 Fumarase Cluster-8309.42163 BP_3 388.69 11.49 1922 642913828 XP_008201177.1 974 1.4e-102 PREDICTED: microtubule-associated protein tau isoform X3 [Tribolium castaneum] -- -- -- -- -- K04380 MAPT, TAU microtubule-associated protein tau http://www.genome.jp/dbget-bin/www_bget?ko:K04380 P15146 324 1.4e-28 Microtubule-associated protein 2 OS=Rattus norvegicus GN=Map2 PE=1 SV=3 PF00418 Tau and MAP protein, tubulin-binding repeat -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex KOG2418 Microtubule-associated protein TAU Cluster-8309.42166 BP_3 376.45 11.17 1916 189235302 XP_001816128.1 402 3.0e-36 PREDICTED: H/ACA ribonucleoprotein complex subunit 1 [Tribolium castaneum]>gi|270003676|gb|EFA00124.1| hypothetical protein TcasGA2_TC002940 [Tribolium castaneum] 766934267 XM_011501142.1 68 1.36335e-24 PREDICTED: Ceratosolen solmsi marchali probable H/ACA ribonucleoprotein complex subunit 1 (LOC105363452), mRNA K11128 GAR1, NOLA1 H/ACA ribonucleoprotein complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11128 Q7KVQ0 330 2.8e-29 Probable H/ACA ribonucleoprotein complex subunit 1 OS=Drosophila melanogaster GN=CG4038 PE=1 SV=1 PF04410 Gar1/Naf1 RNA binding region GO:0042254//GO:0001522//GO:0031120 ribosome biogenesis//pseudouridine synthesis//snRNA pseudouridine synthesis GO:0030515//GO:0009982 snoRNA binding//pseudouridine synthase activity GO:0031429 box H/ACA snoRNP complex KOG3262 H/ACA small nucleolar RNP component GAR1 Cluster-8309.42167 BP_3 52.97 2.27 1415 332373248 AEE61765.1 735 5.4e-75 unknown [Dendroctonus ponderosae]>gi|478262478|gb|ENN81149.1| hypothetical protein YQE_02515, partial [Dendroctonus ponderosae]>gi|546672789|gb|ERL84545.1| hypothetical protein D910_01975 [Dendroctonus ponderosae] 242011937 XM_002426655.1 180 5.49087e-87 Pediculus humanus corporis clathrin coat assembly protein ap19, putative, mRNA K12394 AP1S1_2 AP-1 complex subunit sigma 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12394 Q3ZBS3 659 1.5e-67 AP-1 complex subunit sigma-2 OS=Bos taurus GN=AP1S2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0934 Clathrin adaptor complex, small subunit Cluster-8309.42168 BP_3 17.51 0.34 2788 546682999 ERL92871.1 737 6.3e-75 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42169 BP_3 208.13 24.16 707 642919300 XP_008191816.1 643 1.3e-64 PREDICTED: UDP-glucuronosyltransferase 1-7C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64638 414 1.9e-39 UDP-glucuronosyltransferase 1-5 OS=Rattus norvegicus GN=Ugt1a5 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.4217 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42171 BP_3 29.90 0.38 4127 189237690 XP_969477.2 2746 1.0e-307 PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|642924144|ref|XP_008194025.1| PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|270008133|gb|EFA04581.1| signal-transducer and activator of transcription protein [Tribolium castaneum] 642924143 XM_008195803.1 393 0 PREDICTED: Tribolium castaneum signal-transducer and activator of transcription protein (LOC657965), transcript variant X2, mRNA K11224 STAT5B signal transducer and activator of transcription 5B http://www.genome.jp/dbget-bin/www_bget?ko:K11224 Q9TUZ0 1500 1.3e-164 Signal transducer and activator of transcription 5B OS=Sus scrofa GN=STAT5B PE=2 SV=1 PF02865//PF01017//PF02864 STAT protein, protein interaction domain//STAT protein, all-alpha domain//STAT protein, DNA binding domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0005509//GO:0004871//GO:0003700 calcium ion binding//signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.42172 BP_3 636.16 4.45 7182 546684210 ERL93915.1 1855 3.7e-204 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 119 2.30784e-52 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1311 1.8e-142 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF00614//PF00412//PF01105 Phospholipase D Active site motif//LIM domain//emp24/gp25L/p24 family/GOLD GO:0006810 transport GO:0003824//GO:0008270 catalytic activity//zinc ion binding GO:0016021 integral component of membrane KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.42173 BP_3 24.62 0.34 3785 546684210 ERL93915.1 1800 4.7e-198 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 119 1.21131e-52 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1313 5.7e-143 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF00614//PF00412 Phospholipase D Active site motif//LIM domain -- -- GO:0003824//GO:0008270 catalytic activity//zinc ion binding -- -- KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.42174 BP_3 247.80 6.70 2074 270008737 EFA05185.1 259 1.2e-19 hypothetical protein TcasGA2_TC015315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.42175 BP_3 253.20 6.63 2132 189238116 XP_001814107.1 259 1.3e-19 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.42177 BP_3 129.42 1.51 4410 642931483 XP_008196604.1 1691 2.4e-185 PREDICTED: insulin receptor substrate 1 isoform X8 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 P84770 503 5.6e-49 Insulin receptor substrate 1-B OS=Xenopus laevis GN=irs1-b PE=2 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.42178 BP_3 85.00 11.40 651 665805381 XP_008550881.1 412 7.1e-38 PREDICTED: ER lumen protein-retaining receptor [Microplitis demolitor] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 O76767 400 7.2e-38 ER lumen protein-retaining receptor OS=Drosophila melanogaster GN=KdelR PE=2 SV=1 PF00810 ER lumen protein retaining receptor GO:0006621 protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG3106 ER lumen protein retaining receptor Cluster-8309.42179 BP_3 1348.04 18.27 3848 642922155 XP_008193037.1 4305 0.0e+00 PREDICTED: afadin isoform X2 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 Q9QZQ1 1389 8.9e-152 Afadin OS=Mus musculus GN=Mllt4 PE=1 SV=3 PF13180//PF00595//PF00498//PF16011 PDZ domain//PDZ domain (Also known as DHR or GLGF)//FHA domain//Carbohydrate-binding family 9 GO:0005975//GO:0016052 carbohydrate metabolic process//carbohydrate catabolic process GO:0004553//GO:0030246//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding//protein binding -- -- KOG1892 Actin filament-binding protein Afadin Cluster-8309.42180 BP_3 972.22 4.26 11296 642919281 XP_008191807.1 1507 1.3e-163 PREDICTED: coiled-coil domain-containing protein 85C [Tribolium castaneum] 332376520 BT128443.1 148 2.75227e-68 Dendroctonus ponderosae clone DPO1136_F01 unknown mRNA K07199 PRKAB 5'-AMP-activated protein kinase, regulatory beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07199 Q5BIS9 672 3.6e-68 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus GN=PRKAB1 PE=2 SV=3 PF01907//PF08675//PF07503//PF00992//PF07776//PF13465//PF05443//PF05130//PF02892//PF16622//PF00646//PF03836//PF03462//PF00170//PF06495//PF00096//PF06005//PF02922//PF06156//PF00098//PF12937//PF00076//PF06621//PF04739//PF13912//PF00320 Ribosomal protein L37e//RNA binding domain//HypF finger//Troponin//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//FlgN protein//BED zinc finger//zinc-finger C2H2-type//F-box domain//RasGAP C-terminus//PCRF domain//bZIP transcription factor//Fruit fly transformer protein//Zinc finger, C2H2 type//Protein of unknown function (DUF904)//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//Protein of unknown function (DUF972)//Zinc knuckle//F-box-like//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Single-minded protein C-terminus//5'-AMP-activated protein kinase beta subunit, interaction domain//C2H2-type zinc finger//GATA zinc finger GO:0007264//GO:0042254//GO:0005975//GO:0006260//GO:0006415//GO:0006412//GO:0006449//GO:0006397//GO:0006402//GO:0043093//GO:0000917//GO:0044780//GO:0046660//GO:0051252//GO:0006355 small GTPase mediated signal transduction//ribosome biogenesis//carbohydrate metabolic process//DNA replication//translational termination//translation//regulation of translational termination//mRNA processing//mRNA catabolic process//FtsZ-dependent cytokinesis//barrier septum assembly//bacterial-type flagellum assembly//female sex differentiation//regulation of RNA metabolic process//regulation of transcription, DNA-templated GO:0046872//GO:0003676//GO:0003700//GO:0003735//GO:0005515//GO:0016149//GO:0003723//GO:0003677//GO:0004553//GO:0005096//GO:0008270//GO:0043565//GO:0004535 metal ion binding//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome//protein binding//translation release factor activity, codon specific//RNA binding//DNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds//GTPase activator activity//zinc ion binding//sequence-specific DNA binding//poly(A)-specific ribonuclease activity GO:0005667//GO:0005861//GO:0018444//GO:0005634//GO:0005737//GO:0005840//GO:0005622 transcription factor complex//troponin complex//translation release factor complex//nucleus//cytoplasm//ribosome//intracellular KOG1616 Protein involved in Snf1 protein kinase complex assembly Cluster-8309.42181 BP_3 38.98 1.19 1876 642932644 XP_008196931.1 2374 6.4e-265 PREDICTED: regulatory-associated protein of mTOR isoform X3 [Tribolium castaneum] 657579724 XM_008295570.1 285 3.13067e-145 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 2028 3.5e-226 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF06384 Beta-catenin-interacting protein ICAT -- -- GO:0008013 beta-catenin binding GO:0016342 catenin complex KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.42182 BP_3 32.00 2.37 942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42183 BP_3 7.33 0.50 1002 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42187 BP_3 37.00 18.35 387 531445261 AGT57839.1 166 1.4e-09 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42191 BP_3 674.57 9.48 3723 189239121 XP_001815551.1 604 2.2e-59 PREDICTED: lysM and putative peptidoglycan-binding domain-containing protein 2 [Tribolium castaneum]>gi|270010334|gb|EFA06782.1| hypothetical protein TcasGA2_TC009718 [Tribolium castaneum] 766919473 XM_011505860.1 143 5.42608e-66 PREDICTED: Ceratosolen solmsi marchali transcription initiation factor IIA subunit 2 (LOC105367226), mRNA K03123 TFIIA2, GTF2A2, TOA2 transcription initiation factor TFIIA small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03123 P52656 467 7.0e-45 Transcription initiation factor IIA subunit 2 OS=Drosophila melanogaster GN=TfIIA-S PE=1 SV=1 PF02268//PF02751 Transcription initiation factor IIA, gamma subunit, helical domain//Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex KOG3463 Transcription initiation factor IIA, gamma subunit Cluster-8309.42195 BP_3 27.88 0.53 2809 642931814 XP_008196744.1 1804 1.2e-198 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1215 9.7e-132 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF08127//PF00067 Peptidase family C1 propeptide//Cytochrome P450 GO:0006508//GO:0055114//GO:0050790 proteolysis//oxidation-reduction process//regulation of catalytic activity GO:0016705//GO:0005506//GO:0004197//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//cysteine-type endopeptidase activity//heme binding -- -- -- -- Cluster-8309.42197 BP_3 81.00 33.53 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42198 BP_3 480.27 3.08 7816 270005769 EFA02217.1 6674 0.0e+00 hypothetical protein TcasGA2_TC007876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IEK6 2280 8.7e-255 Ectopic P granules protein 5 homolog OS=Aedes aegypti GN=AAEL009648 PE=3 SV=1 PF12422//PF05493 Condensin II non structural maintenance of chromosomes subunit//ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179//GO:0005634 proton-transporting V-type ATPase, V0 domain//nucleus KOG3622 Uncharacterized conserved protein Cluster-8309.422 BP_3 33.30 0.54 3249 817201410 XP_012276449.1 3668 0.0e+00 PREDICTED: glutamate receptor ionotropic, kainate 2-like [Orussus abietinus] 817201409 XM_012421026.1 639 0 PREDICTED: Orussus abietinus glutamate receptor ionotropic, kainate 2-like (LOC105697583), mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 2093 1.7e-233 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF01726//PF00060//PF10613 LexA DNA binding domain//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0006508//GO:0006811 signal transduction//synaptic transmission//proteolysis//ion transport GO:0004970//GO:0005234//GO:0004252 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.42200 BP_3 247.20 3.18 4037 189235221 XP_967494.2 2057 7.9e-228 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15047 HNRNPUL1, E1BAP5 heterogeneous nuclear ribonucleoprotein U-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15047 Q8VDM6 770 5.6e-80 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Mus musculus GN=Hnrnpul1 PE=1 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.42201 BP_3 199.60 4.83 2282 189240108 XP_972976.2 2104 1.6e-233 PREDICTED: trifunctional purine biosynthetic protein adenosine-3 [Tribolium castaneum]>gi|270011705|gb|EFA08153.1| hypothetical protein TcasGA2_TC005772 [Tribolium castaneum] -- -- -- -- -- K11787 GART phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase http://www.genome.jp/dbget-bin/www_bget?ko:K11787 P21872 1613 5.6e-178 Trifunctional purine biosynthetic protein adenosine-3 OS=Gallus gallus GN=GART PE=2 SV=1 PF00551 Formyl transferase GO:0006189//GO:0009113//GO:0006144//GO:0046653//GO:0009058//GO:0009256//GO:0032259 'de novo' IMP biosynthetic process//purine nucleobase biosynthetic process//purine nucleobase metabolic process//tetrahydrofolate metabolic process//biosynthetic process//10-formyltetrahydrofolate metabolic process//methylation GO:0005524//GO:0004641//GO:0016742//GO:0004637//GO:0008168//GO:0046872//GO:0004644 ATP binding//phosphoribosylformylglycinamidine cyclo-ligase activity//hydroxymethyl-, formyl- and related transferase activity//phosphoribosylamine-glycine ligase activity//methyltransferase activity//metal ion binding//phosphoribosylglycinamide formyltransferase activity GO:0005737 cytoplasm KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS) Cluster-8309.42202 BP_3 722.00 27.50 1557 674304046 AIL23554.1 485 5.8e-46 microsomal glutathione S-transferase [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q91VS7 259 3.9e-21 Microsomal glutathione S-transferase 1 OS=Mus musculus GN=Mgst1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42205 BP_3 20.02 0.49 2257 642934520 XP_001812516.2 607 6.0e-60 PREDICTED: tetraspanin-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42206 BP_3 3456.94 34.13 5174 642936907 XP_008194437.1 2007 6.3e-222 PREDICTED: fasciclin-1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 1362 1.6e-148 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 PF04433//PF15427 SWIRM domain//S100P-binding protein -- -- GO:0005515//GO:0048306 protein binding//calcium-dependent protein binding -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.42211 BP_3 261.85 24.03 817 332372826 AEE61555.1 695 1.4e-70 unknown [Dendroctonus ponderosae]>gi|478261811|gb|ENN80934.1| hypothetical protein YQE_02640, partial [Dendroctonus ponderosae]>gi|546673703|gb|ERL85262.1| hypothetical protein D910_02683 [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 427 6.7e-41 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42212 BP_3 82.33 2.02 2258 642930742 XP_008196074.1 1542 2.3e-168 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18120 220 1.9e-16 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.42213 BP_3 44.15 0.93 2592 642930742 XP_008196074.1 1074 4.9e-114 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18120 220 2.1e-16 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.42214 BP_3 2.38 0.43 561 642923667 XP_008193834.1 465 4.4e-44 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 336 1.6e-30 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42215 BP_3 98.00 5.59 1137 642923667 XP_008193834.1 1072 3.6e-114 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] 645393647 KF926102.1 54 4.84717e-17 Spodoptera exigua strain Xen-R ABCC3 mRNA, complete cds K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 755 8.6e-79 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF03193//PF07728//PF00005//PF13304//PF01926 NB-ARC domain//Protein of unknown function, DUF258//AAA domain (dynein-related subfamily)//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase -- -- GO:0005524//GO:0005525//GO:0016887//GO:0043531//GO:0003924 ATP binding//GTP binding//ATPase activity//ADP binding//GTPase activity -- -- -- -- Cluster-8309.42216 BP_3 85.07 1.13 3911 642923667 XP_008193834.1 3330 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1086 1.2e-116 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00005//PF03193//PF00664//PF13304//PF01926 ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.42217 BP_3 200.69 2.68 3907 642923667 XP_008193834.1 3044 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 989 2.2e-105 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF13304//PF00664 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.42219 BP_3 247.37 3.68 3534 642933817 XP_008197388.1 1238 6.4e-133 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3ZQL6 454 2.1e-43 MICAL-like protein 1 OS=Rattus norvegicus GN=Micall1 PE=1 SV=1 PF00412//PF00307//PF00288 LIM domain//Calponin homology (CH) domain//GHMP kinases N terminal domain -- -- GO:0005524//GO:0008270//GO:0005515 ATP binding//zinc ion binding//protein binding -- -- -- -- Cluster-8309.42220 BP_3 21.27 0.97 1346 170057076 XP_001864320.1 434 4.1e-40 ATP-dependent RNA helicase WM6 [Culex quinquefasciatus]>gi|167876642|gb|EDS40025.1| ATP-dependent RNA helicase WM6 [Culex quinquefasciatus] 827475656 NM_212977.2 111 1.18646e-48 Danio rerio DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Ab (ddx39ab), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 417 1.6e-39 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- GO:0008026//GO:0005524//GO:0003676 ATP-dependent helicase activity//ATP binding//nucleic acid binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.42223 BP_3 13.00 0.41 1810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42224 BP_3 507.06 4.53 5689 642923519 XP_008193543.1 1676 1.7e-183 PREDICTED: coiled-coil domain-containing protein 6 isoform X1 [Tribolium castaneum] 817195200 XM_012417714.1 198 2.21697e-96 PREDICTED: Orussus abietinus coiled-coil domain-containing protein 6 (LOC105695793), mRNA K09288 CCDC6, PTC coiled-coil domain-containing protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09288 Q16204 962 4.3e-102 Coiled-coil domain-containing protein 6 OS=Homo sapiens GN=CCDC6 PE=1 SV=2 PF04434//PF04551//PF04647 SWIM zinc finger//GcpE protein//Accessory gene regulator B GO:0016114//GO:0009405//GO:0009372//GO:0055114 terpenoid biosynthetic process//pathogenesis//quorum sensing//oxidation-reduction process GO:0046429//GO:0008233//GO:0008270 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//peptidase activity//zinc ion binding GO:0016021 integral component of membrane KOG2129 Uncharacterized conserved protein H4 Cluster-8309.42225 BP_3 20.75 0.74 1649 642934319 XP_008198599.1 370 1.3e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42227 BP_3 564.00 17.75 1823 270014963 EFA11411.1 527 9.2e-51 hypothetical protein TcasGA2_TC013586 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02187 Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest -- -- -- -- -- -- Cluster-8309.42232 BP_3 9.84 0.40 1482 769867597 XP_011645818.1 1171 1.6e-125 PREDICTED: zinc finger protein 330 homolog [Pogonomyrmex barbatus] 665810279 XM_008555330.1 203 9.43195e-100 PREDICTED: Microplitis demolitor zinc finger protein 330 homolog (LOC103575512), transcript variant X2, mRNA -- -- -- -- Q9VAU9 1155 4.6e-125 Zinc finger protein 330 homolog OS=Drosophila melanogaster GN=Noa36 PE=1 SV=1 PF03155//PF13912//PF06524 ALG6, ALG8 glycosyltransferase family//C2H2-type zinc finger//NOA36 protein -- -- GO:0008270//GO:0016758//GO:0046872 zinc ion binding//transferase activity, transferring hexosyl groups//metal ion binding GO:0005789//GO:0005634 endoplasmic reticulum membrane//nucleus -- -- Cluster-8309.42233 BP_3 14.47 0.59 1477 357624051 EHJ74956.1 866 3.7e-90 hypothetical protein KGM_12920 [Danaus plexippus] 665810279 XM_008555330.1 104 1.016e-44 PREDICTED: Microplitis demolitor zinc finger protein 330 homolog (LOC103575512), transcript variant X2, mRNA -- -- -- -- Q9VAU9 850 1.1e-89 Zinc finger protein 330 homolog OS=Drosophila melanogaster GN=Noa36 PE=1 SV=1 PF06524//PF13912//PF03155 NOA36 protein//C2H2-type zinc finger//ALG6, ALG8 glycosyltransferase family -- -- GO:0046872//GO:0008270//GO:0016758 metal ion binding//zinc ion binding//transferase activity, transferring hexosyl groups GO:0005789//GO:0005634 endoplasmic reticulum membrane//nucleus -- -- Cluster-8309.42234 BP_3 380.69 16.15 1428 646715259 KDR18930.1 1219 4.1e-131 hypothetical protein L798_06668 [Zootermopsis nevadensis] 665810277 XM_008555329.1 236 4.10662e-118 PREDICTED: Microplitis demolitor zinc finger protein 330 homolog (LOC103575512), transcript variant X1, mRNA -- -- -- -- Q9VAU9 1184 1.9e-128 Zinc finger protein 330 homolog OS=Drosophila melanogaster GN=Noa36 PE=1 SV=1 PF13912//PF06524//PF03155 C2H2-type zinc finger//NOA36 protein//ALG6, ALG8 glycosyltransferase family -- -- GO:0016758//GO:0008270//GO:0046872 transferase activity, transferring hexosyl groups//zinc ion binding//metal ion binding GO:0005634//GO:0005789 nucleus//endoplasmic reticulum membrane -- -- Cluster-8309.42235 BP_3 20.09 0.43 2539 91095137 XP_972151.1 803 1.3e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.14144e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.4e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.42236 BP_3 27.31 0.65 2317 91095137 XP_972151.1 753 7.3e-77 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 1.95158e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 637 8.5e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.42238 BP_3 94.25 4.05 1413 642917782 XP_008191284.1 1636 1.8e-179 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [Tribolium castaneum] 170065886 XM_001868022.1 331 6.28889e-171 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 1551 5.3e-171 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.42239 BP_3 105.37 1.04 5192 270004788 EFA01236.1 630 3.0e-62 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42240 BP_3 961.40 3.95 12018 642929438 XP_008195840.1 3313 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X1 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 2545 2.5e-285 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF00312//PF00520//PF16519//PF12122//PF07992 Ribosomal protein S15//Ion transport protein//Tetramerisation domain of TRPM//Cytoplasmic N-terminal domain of rhomboid serine protease//Pyridine nucleotide-disulphide oxidoreductase GO:0051262//GO:0055085//GO:0006412//GO:0055114//GO:0042254//GO:0006811 protein tetramerization//transmembrane transport//translation//oxidation-reduction process//ribosome biogenesis//ion transport GO:0016491//GO:0003735//GO:0005216//GO:0004252 oxidoreductase activity//structural constituent of ribosome//ion channel activity//serine-type endopeptidase activity GO:0016021//GO:0005840//GO:0005622//GO:0016020 integral component of membrane//ribosome//intracellular//membrane KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.42241 BP_3 576.07 27.38 1306 642926079 XP_008194755.1 840 3.3e-87 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 522 1.0e-51 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01370//PF00106//PF12242 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.42242 BP_3 66.60 1.13 3124 270002093 EEZ98540.1 1018 1.8e-107 hypothetical protein TcasGA2_TC001044 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09297//PF13180//PF00595 NADH pyrophosphatase zinc ribbon domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0046872//GO:0005515//GO:0016787 metal ion binding//protein binding//hydrolase activity -- -- -- -- Cluster-8309.42243 BP_3 2124.40 20.62 5257 270003794 EFA00242.1 2448 4.7e-273 hypothetical protein TcasGA2_TC003070 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.7e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF00621//PF02454 RhoGEF domain//Sigma 1s protein GO:0035023//GO:0043087//GO:0019048 regulation of Rho protein signal transduction//regulation of GTPase activity//modulation by virus of host morphology or physiology GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.42245 BP_3 537.87 4.83 5654 642920336 XP_008192303.1 1655 4.5e-181 PREDICTED: zinc finger CCCH domain-containing protein 14 isoform X1 [Tribolium castaneum]>gi|270005252|gb|EFA01700.1| hypothetical protein TcasGA2_TC007276 [Tribolium castaneum] 462358939 APGK01029925.1 99 2.38155e-41 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- Q5TYQ8 389 1.2e-35 Zinc finger CCCH domain-containing protein 14 OS=Danio rerio GN=zc3h14 PE=2 SV=1 PF01480//PF03595 PWI domain//Voltage-dependent anion channel GO:0006397//GO:0055085 mRNA processing//transmembrane transport -- -- GO:0016021 integral component of membrane KOG3702 Nuclear polyadenylated RNA binding protein Cluster-8309.42249 BP_3 28.95 0.75 2161 91084897 XP_969410.1 888 1.5e-92 PREDICTED: protein NipSnap [Tribolium castaneum]>gi|270008564|gb|EFA05012.1| hypothetical protein TcasGA2_TC015094 [Tribolium castaneum] 195403178 XM_002060136.1 104 1.49793e-44 Drosophila virilis GJ18493 (Dvir\GJ18493), mRNA -- -- -- -- Q9VXK0 764 1.5e-79 Protein NipSnap OS=Drosophila melanogaster GN=Nipsnap PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2883 NIPSNAP1 protein Cluster-8309.42250 BP_3 104.76 2.24 2544 817065189 XP_012254374.1 297 6.0e-24 PREDICTED: uncharacterized protein LOC105685104 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01576//PF04111 Myosin tail//Autophagy protein Apg6 GO:0006914 autophagy GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.42252 BP_3 1602.36 11.26 7148 642919044 XP_008191710.1 2450 3.7e-273 PREDICTED: neurotactin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23654 1366 7.7e-149 Neurotactin OS=Drosophila melanogaster GN=Nrt PE=1 SV=3 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.42253 BP_3 139.90 0.82 8475 478258659 ENN78709.1 2012 2.7e-222 hypothetical protein YQE_04881, partial [Dendroctonus ponderosae] 478512620 XM_004430515.1 38 2.90465e-07 PREDICTED: Ceratotherium simum simum death inducer-obliterator 1 (DIDO1), mRNA -- -- -- -- Q8BFT6 638 2.4e-64 JmjC domain-containing protein 4 OS=Mus musculus GN=Jmjd4 PE=2 SV=1 PF07533//PF06427//PF00628//PF07500 BRK domain//UDP-glucose:Glycoprotein Glucosyltransferase//PHD-finger//Transcription factor S-II (TFIIS), central domain GO:0006351//GO:0006486 transcription, DNA-templated//protein glycosylation GO:0003980//GO:0016817//GO:0005515 UDP-glucose:glycoprotein glucosyltransferase activity//hydrolase activity, acting on acid anhydrides//protein binding -- -- KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.42254 BP_3 8.00 1.78 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42255 BP_3 14.00 3.87 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42257 BP_3 5.41 0.58 745 817061123 XP_012252151.1 145 7.4e-07 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42259 BP_3 189.79 4.44 2353 817061123 XP_012252151.1 374 6.6e-33 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00448//PF00910//PF00004//PF07757//PF04471 SRP54-type protein, GTPase domain//RNA helicase//ATPase family associated with various cellular activities (AAA)//Predicted AdoMet-dependent methyltransferase//Restriction endonuclease GO:0009307//GO:0006614 DNA restriction-modification system//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0008168//GO:0005525//GO:0004519//GO:0003723//GO:0005524//GO:0003677 RNA helicase activity//methyltransferase activity//GTP binding//endonuclease activity//RNA binding//ATP binding//DNA binding -- -- -- -- Cluster-8309.42260 BP_3 50.00 21.41 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42261 BP_3 6.88 0.31 1355 607303795 EZA45171.1 539 2.8e-52 lipase 3-like protein-1, partial [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P04634 381 2.4e-35 Gastric triacylglycerol lipase OS=Rattus norvegicus GN=Lipf PE=1 SV=1 PF02129//PF02450//PF04083 X-Pro dipeptidyl-peptidase (S15 family)//Lecithin:cholesterol acyltransferase//Partial alpha/beta-hydrolase lipase region GO:0042967//GO:0006629 acyl-carrier-protein biosynthetic process//lipid metabolic process GO:0008374//GO:0016787 O-acyltransferase activity//hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.42262 BP_3 3026.53 58.27 2795 546672677 ERL84468.1 1435 7.3e-156 hypothetical protein D910_01899 [Dendroctonus ponderosae] 642918939 XM_008193444.1 321 4.55942e-165 PREDICTED: Tribolium castaneum B-box type zinc finger protein ncl-1-like (LOC662730), transcript variant X6, mRNA -- -- -- -- P34611 526 7.6e-52 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.42263 BP_3 63.31 0.34 9253 546681221 ERL91356.1 1694 2.2e-185 hypothetical protein D910_08688 [Dendroctonus ponderosae] 642927571 XM_008197097.1 82 1.10137e-31 PREDICTED: Tribolium castaneum cAMP-dependent protein kinase type II regulatory subunit (LOC661163), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P81900 1231 4.5e-133 cAMP-dependent protein kinase type II regulatory subunit OS=Drosophila melanogaster GN=Pka-R2 PE=1 SV=2 PF00701//PF15494 Dihydrodipicolinate synthetase family//Scavenger receptor cysteine-rich domain GO:0008152 metabolic process GO:0016829 lyase activity GO:0016020 membrane KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.42265 BP_3 1563.47 40.53 2151 91091790 XP_970226.1 2606 9.2e-292 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X1 [Tribolium castaneum] 195481875 XM_002101781.1 176 1.40885e-84 Drosophila yakuba GE15405 (Dyak\GE15405), partial mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 1818 8.9e-202 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.42266 BP_3 344.96 7.89 2400 189235509 XP_969871.2 1975 1.5e-218 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 721 1.6e-74 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3621 WD40 repeat-containing protein Cluster-8309.42270 BP_3 78.95 2.05 2146 645020639 XP_008207241.1 204 3.1e-13 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42271 BP_3 38.00 0.64 3140 642916820 XP_008199515.1 860 3.9e-89 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|642916822|ref|XP_008199516.1| PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270003069|gb|EEZ99516.1| hypothetical protein TcasGA2_TC000097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6R5N8 333 2.0e-29 Toll-like receptor 13 OS=Mus musculus GN=Tlr13 PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.42272 BP_3 610.00 11.01 2962 332376885 AEE63582.1 817 3.5e-84 unknown [Dendroctonus ponderosae] 642921317 XM_966241.2 83 9.7253e-33 PREDICTED: Tribolium castaneum transmembrane protein 165 (LOC659977), mRNA -- -- -- -- P52875 677 2.5e-69 Transmembrane protein 165 OS=Mus musculus GN=Tmem165 PE=2 SV=2 PF01169 Uncharacterized protein family UPF0016 -- -- -- -- GO:0016020 membrane KOG2881 Predicted membrane protein Cluster-8309.42273 BP_3 361.00 47.76 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42274 BP_3 794.00 48.49 1081 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42275 BP_3 189.31 2.00 4846 766923194 XP_011506210.1 2382 1.9e-265 PREDICTED: rab GTPase-activating protein 1-like isoform X1 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- Q5ZJ17 1531 3.8e-168 Rab GTPase-activating protein 1-like OS=Gallus gallus GN=RABGAP1L PE=2 SV=1 PF07776//PF14719//PF08127//PF00096//PF02892//PF04810//PF01363//PF00640//PF13465 Zinc-finger associated domain (zf-AD)//Phosphotyrosine interaction domain (PTB/PID)//Peptidase family C1 propeptide//Zinc finger, C2H2 type//BED zinc finger//Sec23/Sec24 zinc finger//FYVE zinc finger//Phosphotyrosine interaction domain (PTB/PID)//Zinc-finger double domain GO:0006886//GO:0006888//GO:0050790//GO:0006508 intracellular protein transport//ER to Golgi vesicle-mediated transport//regulation of catalytic activity//proteolysis GO:0005515//GO:0003677//GO:0004197//GO:0046872//GO:0008270 protein binding//DNA binding//cysteine-type endopeptidase activity//metal ion binding//zinc ion binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat -- -- Cluster-8309.42278 BP_3 655.13 4.36 7535 91091506 XP_969096.1 3532 0.0e+00 PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|642936851|ref|XP_008197901.1| PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|270000934|gb|EEZ97381.1| hypothetical protein TcasGA2_TC011206 [Tribolium castaneum] 170030268 XM_001842960.1 189 2.96048e-91 Culex quinquefasciatus ubiquitin-protein ligase E3A, mRNA K10587 UBE3A, E6AP ubiquitin-protein ligase E3 A http://www.genome.jp/dbget-bin/www_bget?ko:K10587 Q05086 2156 2.0e-240 Ubiquitin-protein ligase E3A OS=Homo sapiens GN=UBE3A PE=1 SV=4 PF15798//PF00632//PF00895 Proline-rich AKT1 substrate 1//HECT-domain (ubiquitin-transferase)//ATP synthase protein 8 GO:0015992//GO:0015986//GO:0032007//GO:0016567//GO:0048011 proton transport//ATP synthesis coupled proton transport//negative regulation of TOR signaling//protein ubiquitination//neurotrophin TRK receptor signaling pathway GO:0015078//GO:0004842 hydrogen ion transmembrane transporter activity//ubiquitin-protein transferase activity GO:0005622//GO:0000276 intracellular//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG0941 E3 ubiquitin protein ligase Cluster-8309.42279 BP_3 4.00 0.34 861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42280 BP_3 204.36 16.14 902 242003896 XP_002422903.1 524 1.0e-50 U1 small nuclear ribonucleoprotein 70 kDa, putative [Pediculus humanus corporis]>gi|212505785|gb|EEB10165.1| U1 small nuclear ribonucleoprotein 70 kDa, putative [Pediculus humanus corporis] 766937927 XM_011503139.1 111 7.85791e-49 PREDICTED: Ceratosolen solmsi marchali U1 small nuclear ribonucleoprotein 70 kDa-like (LOC105365059), mRNA K11093 SNRP70 U1 small nuclear ribonucleoprotein 70kDa http://www.genome.jp/dbget-bin/www_bget?ko:K11093 P17133 503 1.1e-49 U1 small nuclear ribonucleoprotein 70 kDa OS=Drosophila melanogaster GN=snRNP-U1-70K PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.42283 BP_3 2964.57 37.05 4148 189241359 XP_971054.2 1182 2.3e-126 PREDICTED: DNA primase small subunit isoform X2 [Tribolium castaneum]>gi|270013128|gb|EFA09576.1| hypothetical protein TcasGA2_TC011690 [Tribolium castaneum] 815822303 XM_012377001.1 72 1.78053e-26 PREDICTED: Linepithema humile DNA primase small subunit (LOC105678028), mRNA K02684 PRI1 DNA primase small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02684 Q24317 930 1.6e-98 DNA primase small subunit OS=Drosophila melanogaster GN=DNApol-alpha50 PE=2 SV=2 PF01896//PF00595//PF13180 Eukaryotic and archaeal DNA primase small subunit//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006260//GO:0006206//GO:0006269//GO:0006351//GO:0006144 DNA replication//pyrimidine nucleobase metabolic process//DNA replication, synthesis of RNA primer//transcription, DNA-templated//purine nucleobase metabolic process GO:0003896//GO:0003899//GO:0005515 DNA primase activity//DNA-directed RNA polymerase activity//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2851 Eukaryotic-type DNA primase, catalytic (small) subunit Cluster-8309.42286 BP_3 2502.91 17.69 7113 91092226 XP_970548.1 8921 0.0e+00 PREDICTED: plexin-A2 [Tribolium castaneum]>gi|642912031|ref|XP_008199067.1| PREDICTED: plexin-A2 [Tribolium castaneum]>gi|270015104|gb|EFA11552.1| plexin A [Tribolium castaneum] 665792256 XM_008545501.1 519 0 PREDICTED: Microplitis demolitor plexin-A4 (LOC103568572), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 P70207 3582 0.0e+00 Plexin-A2 OS=Mus musculus GN=Plxna2 PE=1 SV=2 PF01833//PF01437//PF01403 IPT/TIG domain//Plexin repeat//Sema domain GO:0007165//GO:0007275 signal transduction//multicellular organismal development GO:0005515//GO:0004872 protein binding//receptor activity GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.42287 BP_3 50.30 0.36 6939 91092226 XP_970548.1 8921 0.0e+00 PREDICTED: plexin-A2 [Tribolium castaneum]>gi|642912031|ref|XP_008199067.1| PREDICTED: plexin-A2 [Tribolium castaneum]>gi|270015104|gb|EFA11552.1| plexin A [Tribolium castaneum] 665792256 XM_008545501.1 519 0 PREDICTED: Microplitis demolitor plexin-A4 (LOC103568572), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 P70207 3582 0.0e+00 Plexin-A2 OS=Mus musculus GN=Plxna2 PE=1 SV=2 PF01833//PF01403//PF01437 IPT/TIG domain//Sema domain//Plexin repeat GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0005515//GO:0004872 protein binding//receptor activity GO:0016020//GO:0005622//GO:0016021 membrane//intracellular//integral component of membrane KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.42288 BP_3 8.66 0.47 1180 642920232 XP_008192259.1 148 5.3e-07 PREDICTED: uncharacterized protein LOC103312697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03366//PF09003 YEATS family//Bacteriophage lambda integrase, N-terminal domain GO:0015074//GO:0006355 DNA integration//regulation of transcription, DNA-templated GO:0008907//GO:0003677 integrase activity//DNA binding -- -- -- -- Cluster-8309.42289 BP_3 282.95 3.54 4141 270006069 EFA02517.1 2899 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 199 4.47608e-97 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 P45481 798 3.2e-83 CREB-binding protein OS=Mus musculus GN=Crebbp PE=1 SV=3 PF02135//PF00439//PF02172//PF16987//PF12437 TAZ zinc finger//Bromodomain//KIX domain//KIX domain//Glutamine synthetase type III N terminal GO:0042967//GO:0006807//GO:0009252//GO:0006355 acyl-carrier-protein biosynthetic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process//regulation of transcription, DNA-templated GO:0005515//GO:0004402//GO:0004356//GO:0008270//GO:0003712 protein binding//histone acetyltransferase activity//glutamate-ammonia ligase activity//zinc ion binding//transcription cofactor activity GO:0005667//GO:0005634//GO:0000123 transcription factor complex//nucleus//histone acetyltransferase complex KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.42290 BP_3 1680.55 9.30 9006 270006069 EFA02517.1 3497 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 703 0 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 Q92793 2346 2.2e-262 CREB-binding protein OS=Homo sapiens GN=CREBBP PE=1 SV=3 PF00439//PF07711//PF12437//PF00569//PF09468//PF16987//PF02172//PF09030//PF02135//PF08214 Bromodomain//Rab geranylgeranyl transferase alpha-subunit, insert domain//Glutamine synthetase type III N terminal//Zinc finger, ZZ type//Ydr279p protein family (RNase H2 complex component)//KIX domain//KIX domain//Creb binding//TAZ zinc finger//Histone acetylation protein GO:0016573//GO:0042967//GO:0006355//GO:0009252//GO:0006807 histone acetylation//acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated//peptidoglycan biosynthetic process//nitrogen compound metabolic process GO:0008270//GO:0003712//GO:0004663//GO:0004356//GO:0005515//GO:0003713//GO:0004402 zinc ion binding//transcription cofactor activity//Rab geranylgeranyltransferase activity//glutamate-ammonia ligase activity//protein binding//transcription coactivator activity//histone acetyltransferase activity GO:0005634//GO:0005968//GO:0005667//GO:0000123 nucleus//Rab-protein geranylgeranyltransferase complex//transcription factor complex//histone acetyltransferase complex KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.42292 BP_3 662.16 5.73 5859 91088115 XP_969791.1 1930 6.1e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.8e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF01105//PF04851 DEAD/DEAH box helicase//emp24/gp25L/p24 family/GOLD//Type III restriction enzyme, res subunit GO:0006810 transport GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0008026 ATP binding//DNA binding//hydrolase activity//nucleic acid binding//ATP-dependent helicase activity GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.42297 BP_3 110.23 7.19 1031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03402 Vomeronasal organ pheromone receptor family, V1R GO:0007186//GO:0007606//GO:0019236 G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//response to pheromone GO:0016503 pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.42298 BP_3 4211.96 27.92 7563 270013391 EFA09839.1 9941 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07008 594 2.7e-59 Neurogenic locus notch homolog protein 1 OS=Rattus norvegicus GN=Notch1 PE=1 SV=3 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- -- -- Cluster-8309.42299 BP_3 160.04 1.05 7638 270013391 EFA09839.1 9905 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07008 594 2.7e-59 Neurogenic locus notch homolog protein 1 OS=Rattus norvegicus GN=Notch1 PE=1 SV=3 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- -- -- Cluster-8309.423 BP_3 8.00 2.49 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42301 BP_3 518.83 9.97 2800 478257550 ENN77704.1 2497 5.2e-279 hypothetical protein YQE_05776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VUY0 1367 2.3e-149 MOXD1 homolog 1 OS=Drosophila melanogaster GN=CG5235 PE=2 SV=2 PF07465//PF01082 Photosystem I protein M (PsaM)//Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0055114//GO:0015979 oxidation-reduction process//photosynthesis GO:0016715//GO:0004497//GO:0005507 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity//copper ion binding -- -- KOG3568 Dopamine beta-monooxygenase Cluster-8309.42302 BP_3 1722.97 8.55 10009 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.5e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF00168//PF02891//PF00397//PF05430//PF01155//PF00632 C2 domain//MIZ/SP-RING zinc finger//WW domain//S-adenosyl-L-methionine-dependent methyltransferase//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//HECT-domain (ubiquitin-transferase) GO:0006464//GO:0016567//GO:0055114 cellular protein modification process//protein ubiquitination//oxidation-reduction process GO:0004842//GO:0016151//GO:0005515//GO:0008270//GO:0016645 ubiquitin-protein transferase activity//nickel cation binding//protein binding//zinc ion binding//oxidoreductase activity, acting on the CH-NH group of donors GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.42304 BP_3 73.21 0.78 4845 642914654 XP_008190301.1 1713 7.3e-188 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.89596e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.4e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42305 BP_3 514.61 8.60 3175 91088951 XP_973830.1 1515 4.4e-165 PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|642932526|ref|XP_008197151.1| PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011559|gb|EFA08007.1| hypothetical protein TcasGA2_TC005596 [Tribolium castaneum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q07417 1180 1.3e-127 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acads PE=1 SV=2 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.42306 BP_3 34.78 21.85 365 -- -- -- -- -- 462329210 APGK01040426.1 36 1.48024e-07 Dendroctonus ponderosae Seq01040436, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.42308 BP_3 559.04 5.07 5611 642923061 XP_008200515.1 1804 2.4e-198 PREDICTED: sphingomyelin synthase-related 1-like [Tribolium castaneum]>gi|270006596|gb|EFA03044.1| hypothetical protein TcasGA2_TC010470 [Tribolium castaneum] 755974579 XM_011309074.1 145 6.34255e-67 PREDICTED: Fopius arisanus sphingomyelin synthase-related 1 (LOC105269082), mRNA -- -- -- -- Q9VS60 1131 1.1e-121 Sphingomyelin synthase-related 1 OS=Drosophila melanogaster GN=SMSr PE=1 SV=2 PF12678 RING-H2 zinc finger -- -- GO:0008270 zinc ion binding -- -- KOG3330 Transport protein particle (TRAPP) complex subunit Cluster-8309.4231 BP_3 36.11 1.71 1310 332374592 AEE62437.1 541 1.6e-52 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 331 1.5e-29 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.42310 BP_3 307.69 2.47 6288 642928263 XP_001812997.2 1813 2.4e-199 PREDICTED: cyclin-T [Tribolium castaneum] -- -- -- -- -- K15188 CCNT cyclin T http://www.genome.jp/dbget-bin/www_bget?ko:K15188 O96433 749 2.4e-77 Cyclin-T OS=Drosophila melanogaster GN=CycT PE=1 SV=2 PF00528//PF03604//PF03526//PF02317 Binding-protein-dependent transport system inner membrane component//DNA directed RNA polymerase, 7 kDa subunit//Colicin E1 (microcin) immunity protein//NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain GO:0055114//GO:0006955//GO:0006206//GO:0030153//GO:0006144//GO:0006810//GO:0006351 oxidation-reduction process//immune response//pyrimidine nucleobase metabolic process//bacteriocin immunity//purine nucleobase metabolic process//transport//transcription, DNA-templated GO:0015643//GO:0016491//GO:0050662//GO:0003899//GO:0003677 toxic substance binding//oxidoreductase activity//coenzyme binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0019814//GO:0016020 nucleolus//immunoglobulin complex//membrane KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.42311 BP_3 245.10 1.79 6901 642928264 XP_969418.2 1644 1.0e-179 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q2NL14 660 5.4e-67 KAT8 regulatory NSL complex subunit 2 OS=Bos taurus GN=KANSL2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.42312 BP_3 61.35 0.45 6888 642928264 XP_969418.2 1644 1.0e-179 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q2NL14 660 5.4e-67 KAT8 regulatory NSL complex subunit 2 OS=Bos taurus GN=KANSL2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.42314 BP_3 395.68 2.96 6737 546681938 ERL91934.1 5335 0.0e+00 hypothetical protein D910_09257, partial [Dendroctonus ponderosae] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 O88572 3260 0.0e+00 Low-density lipoprotein receptor-related protein 6 OS=Mus musculus GN=Lrp6 PE=1 SV=1 PF12859//PF00057//PF02244//PF06320 Anaphase-promoting complex subunit 1//Low-density lipoprotein receptor domain class A//Carboxypeptidase activation peptide//GCN5-like protein 1 (GCN5L1) GO:0006508 proteolysis GO:0004180//GO:0005515 carboxypeptidase activity//protein binding GO:0031083//GO:0005680 BLOC-1 complex//anaphase-promoting complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.42316 BP_3 445.80 19.37 1401 189242434 XP_967120.2 498 1.6e-47 PREDICTED: thioredoxin domain-containing protein 17-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DBT3 289 1.2e-24 Thioredoxin domain-containing protein 17 OS=Danio rerio GN=txndc17 PE=2 SV=1 PF13897 Golgi-dynamics membrane-trafficking GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG3425 Uncharacterized conserved protein Cluster-8309.42318 BP_3 2423.50 14.26 8485 91086329 XP_967308.1 2183 4.1e-242 PREDICTED: protein pellino isoform X3 [Tribolium castaneum] 642927955 XM_962215.3 371 0 PREDICTED: Tribolium castaneum protein pellino (LOC662980), transcript variant X3, mRNA K11964 PELI pellino http://www.genome.jp/dbget-bin/www_bget?ko:K11964 O77237 1765 4.9e-195 Protein pellino OS=Drosophila melanogaster GN=Pli PE=1 SV=1 PF14634//PF15723//PF04710//PF05203//PF13897//PF01899//PF13639 zinc-RING finger domain//Motility quorum-sensing regulator, toxin of MqsA//Pellino//Hom_end-associated Hint//Golgi-dynamics membrane-trafficking//Na+/H+ ion antiporter subunit//Ring finger domain GO:0006812//GO:0042710//GO:0017148//GO:0009372//GO:0006810//GO:0030908//GO:0008063 cation transport//biofilm formation//negative regulation of translation//quorum sensing//transport//protein splicing//Toll signaling pathway GO:0008270//GO:0008324//GO:0005515 zinc ion binding//cation transmembrane transporter activity//protein binding GO:0016021 integral component of membrane KOG3842 Adaptor protein Pellino Cluster-8309.42319 BP_3 131.48 0.75 8753 91086329 XP_967308.1 2183 4.2e-242 PREDICTED: protein pellino isoform X3 [Tribolium castaneum] 642927955 XM_962215.3 371 0 PREDICTED: Tribolium castaneum protein pellino (LOC662980), transcript variant X3, mRNA K11964 PELI pellino http://www.genome.jp/dbget-bin/www_bget?ko:K11964 O77237 1765 5.1e-195 Protein pellino OS=Drosophila melanogaster GN=Pli PE=1 SV=1 PF05203//PF15723//PF04710//PF13639//PF01899//PF14634 Hom_end-associated Hint//Motility quorum-sensing regulator, toxin of MqsA//Pellino//Ring finger domain//Na+/H+ ion antiporter subunit//zinc-RING finger domain GO:0030908//GO:0008063//GO:0006812//GO:0017148//GO:0042710//GO:0009372 protein splicing//Toll signaling pathway//cation transport//negative regulation of translation//biofilm formation//quorum sensing GO:0005515//GO:0008270//GO:0008324 protein binding//zinc ion binding//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG3842 Adaptor protein Pellino Cluster-8309.42320 BP_3 561.97 3.02 9254 642932362 XP_008197080.1 3162 0.0e+00 PREDICTED: histone acetyltransferase KAT6A isoform X2 [Tribolium castaneum] 688437395 LL190970.1 59 6.7237e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8WML3 1456 3.6e-159 Histone acetyltransferase KAT6B OS=Macaca fascicularis GN=KAT6B PE=2 SV=1 PF00628//PF01853//PF00538//PF13508//PF01160 PHD-finger//MOZ/SAS family//linker histone H1 and H5 family//Acetyltransferase (GNAT) domain//Vertebrate endogenous opioids neuropeptide GO:0007218//GO:0006355//GO:0042967//GO:0006334 neuropeptide signaling pathway//regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process//nucleosome assembly GO:0016747//GO:0005515//GO:0008080//GO:0003677 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//N-acetyltransferase activity//DNA binding GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.42322 BP_3 5.00 0.69 639 332374452 AEE62367.1 437 8.8e-41 unknown [Dendroctonus ponderosae]>gi|478252607|gb|ENN73012.1| hypothetical protein YQE_10347, partial [Dendroctonus ponderosae]>gi|546677978|gb|ERL88707.1| hypothetical protein D910_06089 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BUZ1 131 1.1e-06 Actin-binding Rho-activating protein OS=Mus musculus GN=Abra PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3376 Uncharacterized conserved protein Cluster-8309.42323 BP_3 121.53 1.75 3640 746838316 XP_011049678.1 1675 1.4e-183 PREDICTED: uncharacterized protein LOC105143221 isoform X1 [Acromyrmex echinatior]>gi|332028468|gb|EGI68511.1| Monocarboxylate transporter 14 [Acromyrmex echinatior] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 447 1.4e-42 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF12537//PF07690//PF00083 The Golgi pH Regulator (GPHR) Family N-terminal//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.42329 BP_3 194.96 2.84 3596 642925776 XP_008201712.1 1713 5.4e-188 PREDICTED: solute carrier family 26 member 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q9BEG8 641 4.5e-65 Sulfate transporter OS=Bos taurus GN=SLC26A2 PE=3 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.42331 BP_3 44.30 10.34 498 270011202 EFA07650.1 569 3.4e-56 hypothetical protein TcasGA2_TC030561 [Tribolium castaneum] -- -- -- -- -- K10428 DCTN6 dynactin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10428 O00399 343 2.2e-31 Dynactin subunit 6 OS=Homo sapiens GN=DCTN6 PE=1 SV=1 PF07959 L-fucokinase -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- KOG4042 Dynactin subunit p27/WS-3, involved in transport of organelles along microtubules Cluster-8309.4234 BP_3 13.00 0.90 987 641651947 XP_008178190.1 338 4.1e-29 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.42341 BP_3 8293.64 96.57 4431 642912785 XP_008201251.1 2124 1.5e-235 PREDICTED: uncharacterized protein LOC663557 isoform X1 [Tribolium castaneum] 215277044 NM_001142346.1 412 0 Nasonia vitripennis uncharacterized LOC100119622 (LOC100119622), mRNA -- -- -- -- Q5XIV0 1035 1.1e-110 Protein FAM46C OS=Rattus norvegicus GN=Fam46c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3852 Uncharacterized conserved protein Cluster-8309.42345 BP_3 1998.99 43.07 2529 642934118 XP_008199283.1 1895 3.0e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1321 4.5e-144 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0006810//GO:0055085//GO:0003333//GO:0006865 transport//transmembrane transport//amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.42346 BP_3 3.85 0.38 777 91083773 XP_972220.1 220 1.6e-15 PREDICTED: uncharacterized protein LOC660933 [Tribolium castaneum]>gi|270006783|gb|EFA03231.1| hypothetical protein TcasGA2_TC013160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335//PF00328 Tetraspanin family//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane -- -- Cluster-8309.42348 BP_3 516.47 28.44 1167 642919843 XP_008192092.1 1010 5.8e-107 PREDICTED: TIP41-like protein [Tribolium castaneum]>gi|270005393|gb|EFA01841.1| hypothetical protein TcasGA2_TC007443 [Tribolium castaneum] -- -- -- -- -- K17607 TIPRL, TIP41 type 2A phosphatase activator TIP41 http://www.genome.jp/dbget-bin/www_bget?ko:K17607 Q8BH58 544 2.6e-54 TIP41-like protein OS=Mus musculus GN=Tiprl PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3224 Uncharacterized conserved protein Cluster-8309.42349 BP_3 43.00 20.32 392 642918534 XP_008191512.1 190 2.4e-12 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42350 BP_3 11.00 193.46 229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42352 BP_3 43.99 0.84 2806 642937904 XP_008200352.1 2094 2.8e-232 PREDICTED: ankyrin repeat and death domain-containing protein 1A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q495B1 764 1.9e-79 Ankyrin repeat and death domain-containing protein 1A OS=Homo sapiens GN=ANKDD1A PE=2 SV=2 PF00531//PF13606//PF00023 Death domain//Ankyrin repeat//Ankyrin repeat GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.42354 BP_3 35.18 0.49 3752 642937904 XP_008200352.1 1073 9.2e-114 PREDICTED: ankyrin repeat and death domain-containing protein 1A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14DN9 434 4.7e-41 Ankyrin repeat and death domain-containing protein 1B OS=Mus musculus GN=Ankdd1b PE=2 SV=3 PF00023//PF13606//PF00531 Ankyrin repeat//Ankyrin repeat//Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.42356 BP_3 36.00 0.31 5880 642912854 XP_008201281.1 2587 4.0e-289 PREDICTED: choline O-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00623 CHAT choline O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00623 P07668 1668 6.0e-184 Choline O-acetyltransferase OS=Drosophila melanogaster GN=Cha PE=1 SV=3 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.42357 BP_3 283.00 20.53 956 91080237 XP_972872.1 762 2.7e-78 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42358 BP_3 1313.09 18.45 3722 642924614 XP_008194364.1 2724 3.3e-305 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 5.2e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF00554//PF01833 Rel homology DNA-binding domain//IPT/TIG domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005515//GO:0003677 transcription factor activity, sequence-specific DNA binding//protein binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42359 BP_3 1507.96 31.92 2569 189239692 XP_967139.2 1433 1.1e-155 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 68 1.83665e-24 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 929 1.3e-98 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF03293//PF01080//PF00957 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Presenilin//Synaptobrevin GO:0006206//GO:0006351//GO:0019083//GO:0006144//GO:0016192 pyrimidine nucleobase metabolic process//transcription, DNA-templated//viral transcription//purine nucleobase metabolic process//vesicle-mediated transport GO:0003899//GO:0003677//GO:0004190 DNA-directed RNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0005730//GO:0016021 nucleolus//integral component of membrane KOG2736 Presenilin Cluster-8309.42360 BP_3 94.98 1.04 4710 478252006 ENN72441.1 2271 1.4e-252 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P79098 1174 9.3e-127 Aminopeptidase N OS=Bos taurus GN=ANPEP PE=2 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.42361 BP_3 46.34 0.36 6477 91092226 XP_970548.1 8628 0.0e+00 PREDICTED: plexin-A2 [Tribolium castaneum]>gi|642912031|ref|XP_008199067.1| PREDICTED: plexin-A2 [Tribolium castaneum]>gi|270015104|gb|EFA11552.1| plexin A [Tribolium castaneum] 665792256 XM_008545501.1 454 0 PREDICTED: Microplitis demolitor plexin-A4 (LOC103568572), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 P70207 3436 0.0e+00 Plexin-A2 OS=Mus musculus GN=Plxna2 PE=1 SV=2 PF01437//PF01403//PF01833 Plexin repeat//Sema domain//IPT/TIG domain GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0005515//GO:0004872 protein binding//receptor activity GO:0016020//GO:0005622//GO:0016021 membrane//intracellular//integral component of membrane KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.42362 BP_3 179.06 6.30 1662 282158091 NP_001164089.1 665 8.4e-67 farnesyl pyrophosphate synthase [Tribolium castaneum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P05369 422 5.2e-40 Farnesyl pyrophosphate synthase OS=Rattus norvegicus GN=Fdps PE=2 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.42365 BP_3 617.24 4.17 7423 91084647 XP_966816.1 4554 0.0e+00 PREDICTED: carboxypeptidase D [Tribolium castaneum] 332374583 BT127471.1 241 3.61564e-120 Dendroctonus ponderosae clone DPO102_A24 unknown mRNA K07752 CPD carboxypeptidase D http://www.genome.jp/dbget-bin/www_bget?ko:K07752 P42787 2788 0.0e+00 Carboxypeptidase D OS=Drosophila melanogaster GN=svr PE=1 SV=2 PF00036//PF04952//PF01694//PF13202//PF13833//PF10591//PF13405//PF00246//PF13499//PF08038//PF12763 EF hand//Succinylglutamate desuccinylase / Aspartoacylase family//Rhomboid family//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Zinc carboxypeptidase//EF-hand domain pair//TOM7 family//Cytoskeletal-regulatory complex EF hand GO:0006508//GO:0007165//GO:0008152//GO:0030150 proteolysis//signal transduction//metabolic process//protein import into mitochondrial matrix GO:0005509//GO:0008270//GO:0004181//GO:0004252//GO:0016788//GO:0005515 calcium ion binding//zinc ion binding//metallocarboxypeptidase activity//serine-type endopeptidase activity//hydrolase activity, acting on ester bonds//protein binding GO:0005578//GO:0005742//GO:0016021 proteinaceous extracellular matrix//mitochondrial outer membrane translocase complex//integral component of membrane KOG2649 Zinc carboxypeptidase Cluster-8309.42366 BP_3 163.00 1.78 4709 642917856 XP_008191315.1 917 1.4e-95 PREDICTED: uncharacterized protein LOC100141538 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.42367 BP_3 660.92 11.43 3079 642913091 XP_008201388.1 2146 2.9e-238 PREDICTED: disks large 1 tumor suppressor protein isoform X10 [Tribolium castaneum] 755966655 XM_011307270.1 318 2.33965e-163 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X5, mRNA K12075 DLG2_3 discs large protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12075 P31007 1823 3.4e-202 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF14604//PF00595//PF00018 PDZ domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.42370 BP_3 941.10 9.96 4848 642921414 XP_008192856.1 2698 4.4e-302 PREDICTED: N-acetylgalactosaminyltransferase 7 [Tribolium castaneum]>gi|270006291|gb|EFA02739.1| hypothetical protein TcasGA2_TC008465 [Tribolium castaneum] 195447413 XM_002071167.1 186 8.8424e-90 Drosophila willistoni GK25256 (Dwil\GK25256), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MV48 2294 1.3e-256 N-acetylgalactosaminyltransferase 7 OS=Drosophila melanogaster GN=GalNAc-T2 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.42371 BP_3 13.35 0.49 1602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42372 BP_3 42.00 0.60 3659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42373 BP_3 695.70 8.27 4347 642931522 XP_008196620.1 1438 5.1e-156 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 1029 5.6e-110 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00288//PF00640//PF13180//PF00595 GHMP kinases N terminal domain//Phosphotyrosine interaction domain (PTB/PID)//PDZ domain//PDZ domain (Also known as DHR or GLGF) GO:0006012//GO:0046835 galactose metabolic process//carbohydrate phosphorylation GO:0004335//GO:0005515//GO:0005524 galactokinase activity//protein binding//ATP binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.42374 BP_3 197.56 0.70 13918 91089729 XP_975072.1 3266 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|642933644|ref|XP_008197508.1| PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|270011308|gb|EFA07756.1| hypothetical protein TcasGA2_TC005310 [Tribolium castaneum] -- -- -- -- -- K05016 CLCN7 chloride channel 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05016 P51798 1876 1.1e-207 H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens GN=CLCN7 PE=1 SV=2 PF03328//PF00709//PF13851//PF15036//PF03790//PF07926//PF09726//PF05837//PF08702//PF02183//PF13326//PF04111//PF00654//PF00170//PF05024//PF10473//PF15898//PF15191//PF00769 HpcH/HpaI aldolase/citrate lyase family//Adenylosuccinate synthetase//Growth-arrest specific micro-tubule binding//Interleukin 34//KNOX1 domain//TPR/MLP1/MLP2-like protein//Transmembrane protein//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Photosystem II Pbs27//Autophagy protein Apg6//Voltage gated chloride channel//bZIP transcription factor//N-acetylglucosaminyl transferase component (Gpi1)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//cGMP-dependent protein kinase interacting domain//Synaptonemal complex central element protein 3//Ezrin/radixin/moesin family GO:0001934//GO:0008283//GO:0048870//GO:0006531//GO:0030168//GO:0010207//GO:0055085//GO:0051382//GO:0006164//GO:0006606//GO:0040007//GO:0007130//GO:0006821//GO:0006144//GO:0006506//GO:0006522//GO:0007165//GO:0006914//GO:0051258//GO:0007131//GO:0006355//GO:0008284//GO:0007283 positive regulation of protein phosphorylation//cell proliferation//cell motility//aspartate metabolic process//platelet activation//photosystem II assembly//transmembrane transport//kinetochore assembly//purine nucleotide biosynthetic process//protein import into nucleus//growth//synaptonemal complex assembly//chloride transport//purine nucleobase metabolic process//GPI anchor biosynthetic process//alanine metabolic process//signal transduction//autophagy//protein polymerization//reciprocal meiotic recombination//regulation of transcription, DNA-templated//positive regulation of cell proliferation//spermatogenesis GO:0008092//GO:0004019//GO:0030674//GO:0045502//GO:0008134//GO:0005157//GO:0005102//GO:0003700//GO:0003677//GO:0003824//GO:0017176//GO:0005525//GO:0042803//GO:0019901//GO:0005247//GO:0043565 cytoskeletal protein binding//adenylosuccinate synthase activity//protein binding, bridging//dynein binding//transcription factor binding//macrophage colony-stimulating factor receptor binding//receptor binding//transcription factor activity, sequence-specific DNA binding//DNA binding//catalytic activity//phosphatidylinositol N-acetylglucosaminyltransferase activity//GTP binding//protein homodimerization activity//protein kinase binding//voltage-gated chloride channel activity//sequence-specific DNA binding GO:0030286//GO:0005667//GO:0000776//GO:0019898//GO:0005577//GO:0005615//GO:0005634//GO:0016020//GO:0031514//GO:0016021//GO:0005737 dynein complex//transcription factor complex//kinetochore//extrinsic component of membrane//fibrinogen complex//extracellular space//nucleus//membrane//motile cilium//integral component of membrane//cytoplasm KOG0474 Cl- channel CLC-7 and related proteins (CLC superfamily) Cluster-8309.42376 BP_3 282.22 4.23 3506 642933500 XP_008197443.1 2478 1.0e-276 PREDICTED: rho GTPase-activating protein 20-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2F6 386 1.6e-35 Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2 PF00788//PF00620 Ras association (RalGDS/AF-6) domain//RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.42379 BP_3 872.49 5.96 7342 260436903 NP_001159498.1 879 5.7e-91 U-box domain containing 5 [Tribolium castaneum] -- -- -- -- -- K10600 UBOX5, UIP5 U-box domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10600 Q925F4 318 2.6e-27 RING finger protein 37 OS=Mus musculus GN=Ubox5 PE=1 SV=2 PF04564//PF14634 U-box domain//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//protein binding -- -- -- -- Cluster-8309.4238 BP_3 14.11 2.90 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42380 BP_3 332.26 3.58 4769 546683539 ERL93341.1 1541 6.3e-168 hypothetical protein D910_10634 [Dendroctonus ponderosae] -- -- -- -- -- K10641 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 http://www.genome.jp/dbget-bin/www_bget?ko:K10641 Q6UWE0 703 3.9e-72 E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens GN=LRSAM1 PE=1 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.42381 BP_3 500.61 5.25 4887 91090894 XP_973482.1 1323 1.2e-142 PREDICTED: ileal sodium/bile acid cotransporter isoform X1 [Tribolium castaneum]>gi|270013229|gb|EFA09677.1| hypothetical protein TcasGA2_TC011805 [Tribolium castaneum] -- -- -- -- -- K14343 SLC10A3_5 solute carrier family 10 (sodium/bile acid cotransporter), member 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14343 P09131 356 6.9e-32 P3 protein OS=Homo sapiens GN=SLC10A3 PE=2 SV=1 PF04785//PF01758 Rhabdovirus matrix protein M2//Sodium Bile acid symporter family GO:0016032 viral process -- -- GO:0016020//GO:0019031 membrane//viral envelope KOG2718 Na+-bile acid cotransporter Cluster-8309.42383 BP_3 1628.79 8.35 9697 642916116 XP_008190891.1 1596 5.4e-174 PREDICTED: nuclear pore complex protein Nup153 [Tribolium castaneum] 642916113 XM_008192668.1 546 0 PREDICTED: Tribolium castaneum WW domain-containing adapter protein with coiled-coil (LOC660923), mRNA -- -- -- -- P49790 578 2.5e-57 Nuclear pore complex protein Nup153 OS=Homo sapiens GN=NUP153 PE=1 SV=2 PF03172//PF00397//PF00641//PF03083 Sp100 domain//WW domain//Zn-finger in Ran binding protein and others//Sugar efflux transporter for intercellular exchange -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.42384 BP_3 1313.27 6.81 9593 642916116 XP_008190891.1 1596 5.3e-174 PREDICTED: nuclear pore complex protein Nup153 [Tribolium castaneum] 642916113 XM_008192668.1 379 0 PREDICTED: Tribolium castaneum WW domain-containing adapter protein with coiled-coil (LOC660923), mRNA -- -- -- -- P49790 578 2.4e-57 Nuclear pore complex protein Nup153 OS=Homo sapiens GN=NUP153 PE=1 SV=2 PF03083//PF03172//PF00397//PF00641 Sugar efflux transporter for intercellular exchange//Sp100 domain//WW domain//Zn-finger in Ran binding protein and others -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.42386 BP_3 299.00 7.90 2117 -- -- -- -- -- 642917392 XM_008201450.1 41 1.54141e-09 PREDICTED: Tribolium castaneum ribosomal protein S6 kinase alpha-5 (LOC658616), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42388 BP_3 168.48 1.81 4782 642917393 XP_008199672.1 3544 0.0e+00 PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X2 [Tribolium castaneum] 795078999 XM_012021559.1 166 1.14422e-78 PREDICTED: Vollenhovia emeryi ribosomal protein S6 kinase alpha-5 (LOC105567037), transcript variant X2, mRNA K04445 MSK1, RPS6KA5 ribosomal protein S6 kinase alpha-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04445 O75582 2231 2.6e-249 Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens GN=RPS6KA5 PE=1 SV=1 PF00069//PF06293//PF00433//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.42389 BP_3 21.74 1.03 1313 478250013 ENN70519.1 965 1.1e-101 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 560 4.1e-56 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.4239 BP_3 4.00 0.33 878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42392 BP_3 948.30 55.86 1110 332374186 AEE62234.1 1501 6.4e-164 unknown [Dendroctonus ponderosae] 673526012 HG529539.1 38 3.70746e-08 Melanopsichium pennsylvanicum 4 genomic scaffold, scaffold SCAFFOLD72 K03030 PSMD14, RPN11, POH1 26S proteasome regulatory subunit N11 http://www.genome.jp/dbget-bin/www_bget?ko:K03030 Q9V3H2 1448 3.7e-159 26S proteasome non-ATPase regulatory subunit 14 OS=Drosophila melanogaster GN=Rpn11 PE=1 SV=1 PF01398//PF09412 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Endoribonuclease XendoU -- -- GO:0005515//GO:0016788 protein binding//hydrolase activity, acting on ester bonds -- -- KOG1555 26S proteasome regulatory complex, subunit RPN11 Cluster-8309.42393 BP_3 8.70 0.47 1178 332374186 AEE62234.1 1501 6.8e-164 unknown [Dendroctonus ponderosae] 673526012 HG529539.1 38 3.93707e-08 Melanopsichium pennsylvanicum 4 genomic scaffold, scaffold SCAFFOLD72 K03030 PSMD14, RPN11, POH1 26S proteasome regulatory subunit N11 http://www.genome.jp/dbget-bin/www_bget?ko:K03030 Q9V3H2 1448 3.9e-159 26S proteasome non-ATPase regulatory subunit 14 OS=Drosophila melanogaster GN=Rpn11 PE=1 SV=1 PF09412//PF01398 Endoribonuclease XendoU//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515//GO:0016788 protein binding//hydrolase activity, acting on ester bonds -- -- KOG1555 26S proteasome regulatory complex, subunit RPN11 Cluster-8309.42395 BP_3 32.49 0.46 3718 270003898 EFA00346.1 1651 8.7e-181 hypothetical protein TcasGA2_TC003186 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60271 905 1.1e-95 C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens GN=SPAG9 PE=1 SV=4 PF04508//PF10186//PF01496//PF06156//PF04111//PF01763//PF00458//PF17082//PF02601//PF10473 Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14//V-type ATPase 116kDa subunit family//Protein of unknown function (DUF972)//Autophagy protein Apg6//Herpesvirus UL6 like//WHEP-TRS domain//Spindle Pole Component 29//Exonuclease VII, large subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006914//GO:0006260//GO:0006323//GO:0010508//GO:0015992//GO:0016032//GO:0015991//GO:0030474//GO:0006418//GO:0006308 autophagy//DNA replication//DNA packaging//positive regulation of autophagy//proton transport//viral process//ATP hydrolysis coupled proton transport//spindle pole body duplication//tRNA aminoacylation for protein translation//DNA catabolic process GO:0005524//GO:0008134//GO:0045502//GO:0015078//GO:0005200//GO:0004812//GO:0008855//GO:0042803 ATP binding//transcription factor binding//dynein binding//hydrogen ion transmembrane transporter activity//structural constituent of cytoskeleton//aminoacyl-tRNA ligase activity//exodeoxyribonuclease VII activity//protein homodimerization activity GO:0009318//GO:0005823//GO:0005856//GO:0030286//GO:0005667//GO:0033179 exodeoxyribonuclease VII complex//central plaque of spindle pole body//cytoskeleton//dynein complex//transcription factor complex//proton-transporting V-type ATPase, V0 domain KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.42396 BP_3 689.12 10.72 3390 642939191 XP_008200374.1 647 2.1e-64 PREDICTED: DNA-binding protein P3A2 isoform X5 [Tribolium castaneum] 642939190 XM_008202152.1 172 3.73564e-82 PREDICTED: Tribolium castaneum DNA-binding protein Ewg (LOC658623), transcript variant X7, mRNA K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 267 9.9e-22 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 PF00731 AIR carboxylase GO:0006189 'de novo' IMP biosynthetic process -- -- -- -- -- -- Cluster-8309.42397 BP_3 36.88 0.55 3546 478254065 ENN74357.1 365 1.1e-31 hypothetical protein YQE_09327, partial [Dendroctonus ponderosae] 642939190 XM_008202152.1 91 4.1664e-37 PREDICTED: Tribolium castaneum DNA-binding protein Ewg (LOC658623), transcript variant X7, mRNA K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 155 1.0e-08 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42398 BP_3 159.76 5.73 1636 91085557 XP_966821.1 987 3.8e-104 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 409 1.6e-38 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13414//PF00254//PF13371//PF13181//PF00515 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.42399 BP_3 47.71 0.57 4353 642925954 XP_008195644.1 2047 1.2e-226 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13192 RBM26 RNA-binding protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K13192 Q2T9I5 522 3.4e-51 RNA-binding protein 26 OS=Xenopus laevis GN=rbm26 PE=2 SV=2 PF01429//PF00642//PF00076//PF01480 Methyl-CpG binding domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PWI domain GO:0006397 mRNA processing GO:0003676//GO:0003677//GO:0046872 nucleic acid binding//DNA binding//metal ion binding GO:0005634 nucleus KOG2135 Proteins containing the RNA recognition motif Cluster-8309.42400 BP_3 934.42 16.98 2944 91089397 XP_974004.1 3350 0.0e+00 PREDICTED: pyridoxal-dependent decarboxylase domain-containing protein 1 [Tribolium castaneum]>gi|270011423|gb|EFA07871.1| hypothetical protein TcasGA2_TC005445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DF78 1043 9.0e-112 Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Xenopus laevis GN=pdxdc1 PE=2 SV=1 PF00282//PF00964 Pyridoxal-dependent decarboxylase conserved domain//Elicitin GO:0006952//GO:0019752//GO:0009405 defense response//carboxylic acid metabolic process//pathogenesis GO:0030170//GO:0016831 pyridoxal phosphate binding//carboxy-lyase activity GO:0005576 extracellular region KOG0630 Predicted pyridoxal-dependent decarboxylase Cluster-8309.42401 BP_3 48.84 0.48 5207 478253546 ENN73864.1 968 1.9e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.95072e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 1.0e-81 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF06814//PF01529 Peptidase family M50//Lung seven transmembrane receptor//DHHC palmitoyltransferase GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0016021 integral component of membrane KOG2585 Uncharacterized conserved protein Cluster-8309.42402 BP_3 3919.17 45.76 4420 91082195 XP_971684.1 1399 1.7e-151 PREDICTED: nipped-B-like protein B [Tribolium castaneum]>gi|270007443|gb|EFA03891.1| hypothetical protein TcasGA2_TC014015 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T200 132 5.8e-06 Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens GN=ZC3H13 PE=1 SV=1 PF00642//PF03176 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//MMPL family -- -- GO:0046872 metal ion binding GO:0016020 membrane -- -- Cluster-8309.42403 BP_3 742.26 7.80 4876 861599125 KMQ83546.1 322 1.5e-26 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF13404 Transposase//AsnC-type helix-turn-helix domain GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0043565//GO:0003677 sequence-specific DNA binding//DNA binding -- -- -- -- Cluster-8309.42404 BP_3 124.15 1.29 4943 861599125 KMQ83546.1 644 6.8e-64 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404//PF01498 AsnC-type helix-turn-helix domain//Transposase GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0043565//GO:0003677 sequence-specific DNA binding//DNA binding -- -- -- -- Cluster-8309.42405 BP_3 353.00 9.27 2127 189235300 XP_974730.2 707 1.4e-71 PREDICTED: la-related protein 7 [Tribolium castaneum]>gi|270004171|gb|EFA00619.1| hypothetical protein TcasGA2_TC003495 [Tribolium castaneum] -- -- -- -- -- K15191 LARP7 La-related protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15191 Q7ZWE3 360 1.0e-32 La-related protein 7 OS=Danio rerio GN=larp7 PE=2 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0044424 intracellular part KOG0118 FOG: RRM domain Cluster-8309.42406 BP_3 31.07 0.73 2342 642917967 XP_008198963.1 2827 0.0e+00 PREDICTED: pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Tribolium castaneum]>gi|270004690|gb|EFA01138.1| hypothetical protein TcasGA2_TC010363 [Tribolium castaneum] -- -- -- -- -- K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 1249 9.3e-136 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF01494//PF07992//PF01266//PF12831//PF00070 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0006563//GO:0006566//GO:0055114//GO:0006546//GO:0006544 L-serine metabolic process//threonine metabolic process//oxidation-reduction process//glycine catabolic process//glycine metabolic process GO:0071949//GO:0016491//GO:0004047 FAD binding//oxidoreductase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.42408 BP_3 1255.88 12.17 5267 189238186 XP_966734.2 2332 1.3e-259 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 642925605 XM_008196416.1 565 0 PREDICTED: Tribolium castaneum hippocampus abundant transcript 1 protein (LOC661725), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 6.7e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF07690//PF00400 Major Facilitator Superfamily//WD domain, G-beta repeat GO:0055085 transmembrane transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.42411 BP_3 2024.61 86.34 1422 728416984 AIY68330.1 1849 3.6e-204 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 763 1.3e-79 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.42413 BP_3 33.23 0.31 5484 91076774 XP_973840.1 1189 4.8e-127 PREDICTED: autophagy protein 5 [Tribolium castaneum]>gi|270001850|gb|EEZ98297.1| hypothetical protein TcasGA2_TC000747 [Tribolium castaneum] 170060949 XM_001865993.1 65 1.83658e-22 Culex quinquefasciatus Autophagy-specific protein, mRNA K08339 ATG5 autophagy-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08339 Q9W3R7 857 6.2e-90 Autophagy protein 5 OS=Drosophila melanogaster GN=Atg5 PE=2 SV=2 PF06309//PF04106//PF16094//PF07728 Torsin//Autophagy protein Apg5//Proteasome assembly chaperone 4//AAA domain (dynein-related subfamily) GO:0043248//GO:0006914 proteasome assembly//autophagy GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0005737//GO:0005783 cytoplasm//endoplasmic reticulum KOG2170 ATPase of the AAA+ superfamily Cluster-8309.42414 BP_3 658.67 5.74 5823 189238796 XP_974873.2 578 3.6e-56 PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|642927324|ref|XP_008195221.1| PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|270009983|gb|EFA06431.1| hypothetical protein TcasGA2_TC009311 [Tribolium castaneum] -- -- -- -- -- K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q4VBS4 427 4.8e-40 Methionine aminopeptidase 1D, mitochondrial OS=Danio rerio GN=metap1d PE=2 SV=1 -- -- GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2738 Putative methionine aminopeptidase Cluster-8309.42415 BP_3 3065.55 26.62 5843 642916547 XP_008191645.1 1931 4.6e-213 PREDICTED: uncharacterized protein LOC103312116 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q792Q4 427 4.8e-40 Cysteine-rich PDZ-binding protein OS=Rattus norvegicus GN=Cript PE=1 SV=1 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3476 Microtubule-associated protein CRIPT Cluster-8309.42418 BP_3 649.59 5.16 6365 642914286 XP_008201622.1 2509 4.8e-280 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X2 [Tribolium castaneum] 642914285 XM_008203400.1 534 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 6-like (LOC663221), transcript variant X2, mRNA K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 Q8VEG6 1589 9.5e-175 CCR4-NOT transcription complex subunit 6-like OS=Mus musculus GN=Cnot6l PE=1 SV=2 PF13855//PF14987//PF06988//PF00560//PF01465//PF16093//PF08395 Leucine rich repeat//NADH dehydrogenase 1 alpha subcomplex subunit 3//NifT/FixU protein//Leucine Rich Repeat//GRIP domain//Proteasome assembly chaperone 4//7tm Chemosensory receptor GO:0000042//GO:0043248//GO:0050909//GO:0009399 protein targeting to Golgi//proteasome assembly//sensory perception of taste//nitrogen fixation GO:0005515 protein binding GO:0005747//GO:0016021//GO:0005743 mitochondrial respiratory chain complex I//integral component of membrane//mitochondrial inner membrane KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.42419 BP_3 870.46 6.28 6968 642914286 XP_008201622.1 2509 5.3e-280 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X2 [Tribolium castaneum] 642914285 XM_008203400.1 534 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 6-like (LOC663221), transcript variant X2, mRNA K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 Q8VEG6 1589 1.0e-174 CCR4-NOT transcription complex subunit 6-like OS=Mus musculus GN=Cnot6l PE=1 SV=2 PF08395//PF01465//PF16093//PF00560//PF06988//PF14987//PF13855 7tm Chemosensory receptor//GRIP domain//Proteasome assembly chaperone 4//Leucine Rich Repeat//NifT/FixU protein//NADH dehydrogenase 1 alpha subcomplex subunit 3//Leucine rich repeat GO:0009399//GO:0000042//GO:0043248//GO:0050909 nitrogen fixation//protein targeting to Golgi//proteasome assembly//sensory perception of taste GO:0005515 protein binding GO:0016021//GO:0005743//GO:0005747 integral component of membrane//mitochondrial inner membrane//mitochondrial respiratory chain complex I KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.42421 BP_3 101.29 1.35 3917 642922869 XP_008200431.1 2031 7.9e-225 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1465 1.4e-160 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF13304//PF01926//PF00005//PF03193//PF00236//PF12844 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258//Glycoprotein hormone//Helix-turn-helix domain GO:0055085//GO:0007165//GO:0006810 transmembrane transport//signal transduction//transport GO:0016887//GO:0005525//GO:0043565//GO:0042626//GO:0005524//GO:0003924//GO:0005179 ATPase activity//GTP binding//sequence-specific DNA binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.42422 BP_3 8.72 0.40 1347 642912660 XP_008200953.1 1155 1.0e-123 PREDICTED: aldose reductase-like [Tribolium castaneum]>gi|270002625|gb|EEZ99072.1| hypothetical protein TcasGA2_TC004950 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P45376 614 2.3e-62 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.42423 BP_3 71.46 0.61 5967 642920893 XP_973626.3 1474 4.7e-160 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09668 LARGE glycosyltransferase-like protein LARGE http://www.genome.jp/dbget-bin/www_bget?ko:K09668 Q66PG3 757 2.7e-78 Glycosyltransferase-like protein LARGE1 OS=Gallus gallus GN=LARGE PE=2 SV=1 PF00711//PF09329//PF01545//PF01501//PF02844 Beta defensin//Primase zinc finger//Cation efflux family//Glycosyl transferase family 8//Phosphoribosylglycinamide synthetase, N domain GO:0006952//GO:0006144//GO:0009113//GO:0055085//GO:0006812//GO:0006260 defense response//purine nucleobase metabolic process//purine nucleobase biosynthetic process//transmembrane transport//cation transport//DNA replication GO:0016757//GO:0008324//GO:0004637 transferase activity, transferring glycosyl groups//cation transmembrane transporter activity//phosphoribosylamine-glycine ligase activity GO:0005634//GO:0016021//GO:0005576 nucleus//integral component of membrane//extracellular region KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.42424 BP_3 1530.22 29.17 2820 91087199 XP_966953.1 1966 2.0e-217 PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|642929856|ref|XP_008196002.1| PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|270009518|gb|EFA05966.1| hypothetical protein TcasGA2_TC008785 [Tribolium castaneum] -- -- -- -- -- K17917 SNX1_2 sorting nexin-1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17917 Q9CWK8 1117 2.3e-120 Sorting nexin-2 OS=Mus musculus GN=Snx2 PE=1 SV=2 PF00787//PF01025 PX domain//GrpE GO:0007154//GO:0006457 cell communication//protein folding GO:0035091//GO:0000774//GO:0051087//GO:0042803 phosphatidylinositol binding//adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.42425 BP_3 427.65 4.78 4605 642915700 XP_008190765.1 3280 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X3 [Tribolium castaneum] 642915699 XM_008192543.1 679 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 7.0e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.42426 BP_3 93.32 1.03 4639 270013465 EFA09913.1 1341 9.6e-145 hypothetical protein TcasGA2_TC012064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02663 568 1.7e-56 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF07690//PF00083//PF04101//PF00201 Major Facilitator Superfamily//Sugar (and other) transporter//Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152//GO:0055085 metabolic process//transmembrane transport GO:0016758//GO:0022857 transferase activity, transferring hexosyl groups//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.42427 BP_3 8.62 0.35 1488 642923823 XP_008193894.1 576 1.6e-56 PREDICTED: uncharacterized protein LOC103313156 [Tribolium castaneum]>gi|270007762|gb|EFA04210.1| hypothetical protein TcasGA2_TC014459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00822//PF13903 PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42429 BP_3 649.83 3.06 10537 91077334 XP_974850.1 2102 1.2e-232 PREDICTED: amidophosphoribosyltransferase [Tribolium castaneum]>gi|270001665|gb|EEZ98112.1| hypothetical protein TcasGA2_TC000530 [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1736 1.4e-191 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF00156//PF01166//PF10473//PF17060//PF00769//PF13405//PF04111//PF11380//PF02465//PF01401//PF04728//PF05404//PF00038//PF04632//PF07851//PF04508 Phosphoribosyl transferase domain//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Monopolar spindle protein 2//Ezrin/radixin/moesin family//EF-hand domain//Autophagy protein Apg6//Stealth protein CR2, conserved region 2//Flagellar hook-associated protein 2 N-terminus//Angiotensin-converting enzyme//Lipoprotein leucine-zipper//Translocon-associated protein, delta subunit precursor (TRAP-delta)//Intermediate filament protein//Fusaric acid resistance protein family//TMPIT-like protein//Viral A-type inclusion protein repeat GO:0006189//GO:0006914//GO:0006536//GO:0009113//GO:0006810//GO:0006355//GO:0009116//GO:0006541//GO:0006144//GO:0071988//GO:0016032//GO:0030474//GO:0006508 'de novo' IMP biosynthetic process//autophagy//glutamate metabolic process//purine nucleobase biosynthetic process//transport//regulation of transcription, DNA-templated//nucleoside metabolic process//glutamine metabolic process//purine nucleobase metabolic process//protein localization to spindle pole body//viral process//spindle pole body duplication//proteolysis GO:0005198//GO:0051536//GO:0042803//GO:0008134//GO:0045502//GO:0008241//GO:0016772//GO:0004044//GO:0003700//GO:0008092//GO:0005509//GO:0008237//GO:0046872 structural molecule activity//iron-sulfur cluster binding//protein homodimerization activity//transcription factor binding//dynein binding//peptidyl-dipeptidase activity//transferase activity, transferring phosphorus-containing groups//amidophosphoribosyltransferase activity//transcription factor activity, sequence-specific DNA binding//cytoskeletal protein binding//calcium ion binding//metallopeptidase activity//metal ion binding GO:0016021//GO:0005737//GO:0005886//GO:0019867//GO:0005783//GO:0016020//GO:0019898//GO:0005882//GO:0030286//GO:0005667//GO:0009424 integral component of membrane//cytoplasm//plasma membrane//outer membrane//endoplasmic reticulum//membrane//extrinsic component of membrane//intermediate filament//dynein complex//transcription factor complex//bacterial-type flagellum hook KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.42430 BP_3 121.19 0.57 10587 91077334 XP_974850.1 2102 1.2e-232 PREDICTED: amidophosphoribosyltransferase [Tribolium castaneum]>gi|270001665|gb|EEZ98112.1| hypothetical protein TcasGA2_TC000530 [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1736 1.4e-191 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF07851//PF04111//PF13405//PF04632//PF04508//PF02465//PF10473//PF01166//PF04728//PF01401//PF00156//PF00769//PF00038//PF17060//PF05404 TMPIT-like protein//Autophagy protein Apg6//EF-hand domain//Fusaric acid resistance protein family//Viral A-type inclusion protein repeat//Flagellar hook-associated protein 2 N-terminus//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TSC-22/dip/bun family//Lipoprotein leucine-zipper//Angiotensin-converting enzyme//Phosphoribosyl transferase domain//Ezrin/radixin/moesin family//Intermediate filament protein//Monopolar spindle protein 2//Translocon-associated protein, delta subunit precursor (TRAP-delta) GO:0030474//GO:0016032//GO:0006508//GO:0006144//GO:0071988//GO:0006536//GO:0009113//GO:0006810//GO:0006914//GO:0006189//GO:0006541//GO:0009116//GO:0006355 spindle pole body duplication//viral process//proteolysis//purine nucleobase metabolic process//protein localization to spindle pole body//glutamate metabolic process//purine nucleobase biosynthetic process//transport//autophagy//'de novo' IMP biosynthetic process//glutamine metabolic process//nucleoside metabolic process//regulation of transcription, DNA-templated GO:0008092//GO:0046872//GO:0008237//GO:0005509//GO:0008241//GO:0045502//GO:0008134//GO:0003700//GO:0004044//GO:0042803//GO:0005198//GO:0051536 cytoskeletal protein binding//metal ion binding//metallopeptidase activity//calcium ion binding//peptidyl-dipeptidase activity//dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//amidophosphoribosyltransferase activity//protein homodimerization activity//structural molecule activity//iron-sulfur cluster binding GO:0005667//GO:0030286//GO:0009424//GO:0005882//GO:0019898//GO:0005783//GO:0005886//GO:0019867//GO:0016020//GO:0016021//GO:0005737 transcription factor complex//dynein complex//bacterial-type flagellum hook//intermediate filament//extrinsic component of membrane//endoplasmic reticulum//plasma membrane//outer membrane//membrane//integral component of membrane//cytoplasm KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.42435 BP_3 69.65 0.35 9917 91085247 XP_973234.1 3413 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 316 9.82343e-162 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 2247 7.4e-251 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF05997//PF11698//PF08064//PF02985//PF00015//PF00083//PF07690//PF14372//PF06009 Nucleolar protein,Nop52//V-ATPase subunit H//UME (NUC010) domain//HEAT repeat//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sugar (and other) transporter//Major Facilitator Superfamily//Domain of unknown function (DUF4413)//Laminin Domain II GO:0006364//GO:0009069//GO:0007165//GO:0055085//GO:0007155//GO:0016310//GO:0015991 rRNA processing//serine family amino acid metabolic process//signal transduction//transmembrane transport//cell adhesion//phosphorylation//ATP hydrolysis coupled proton transport GO:0004674//GO:0004871//GO:0016820//GO:0005515//GO:0003677//GO:0022857 protein serine/threonine kinase activity//signal transducer activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//DNA binding//transmembrane transporter activity GO:0030688//GO:0016021//GO:0016020//GO:0000221 preribosome, small subunit precursor//integral component of membrane//membrane//vacuolar proton-transporting V-type ATPase, V1 domain KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.42437 BP_3 460.02 5.83 4097 642924882 XP_008194082.1 2220 1.0e-246 PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|642924884|ref|XP_008194083.1| PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|270008015|gb|EFA04463.1| hypothetical protein TcasGA2_TC014767 [Tribolium castaneum] 795080210 XM_012021821.1 347 2.36304e-179 PREDICTED: Vollenhovia emeryi serine/threonine-protein kinase 25 (LOC105567182), transcript variant X6, mRNA K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 B0LT89 1090 4.4e-117 Serine/threonine-protein kinase 24 OS=Rattus norvegicus GN=Stk24 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0201 Serine/threonine protein kinase Cluster-8309.42440 BP_3 139.44 2.40 3097 642930308 XP_008196340.1 1113 1.8e-118 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 9.3e-35 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42441 BP_3 113.66 1.66 3600 350415209 XP_003490566.1 2235 1.6e-248 PREDICTED: protein Skeletor, isoforms B/C [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q9VGY6 406 8.0e-38 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42442 BP_3 18695.34 281.31 3495 649572249 NP_001280546.1 2673 2.5e-299 protein Skeletor, isoforms B/C precursor [Tribolium castaneum]>gi|270012993|gb|EFA09441.1| hypothetical protein TcasGA2_TC010653 [Tribolium castaneum]>gi|343787531|gb|AEM60136.1| knickkopf [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 753 4.5e-78 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42443 BP_3 655.92 59.51 823 91076392 XP_968727.1 1126 1.4e-120 PREDICTED: proteasome subunit alpha type-2 [Tribolium castaneum]>gi|270002557|gb|EEZ99004.1| hypothetical protein TcasGA2_TC004868 [Tribolium castaneum] 389611552 AK402776.1 159 1.48187e-75 Papilio xuthus mRNA for proteasome 25kD subunit, partial cds, sequence id: Px-0378, expressed in epidermis K02726 PSMA2 20S proteasome subunit alpha 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02726 P40301 1020 1.2e-109 Proteasome subunit alpha type-2 OS=Drosophila melanogaster GN=Prosalpha2 PE=1 SV=1 PF10584//PF00227 Proteasome subunit A N-terminal signature//Proteasome subunit GO:0051603//GO:0006511 proteolysis involved in cellular protein catabolic process//ubiquitin-dependent protein catabolic process GO:0004298//GO:0004175 threonine-type endopeptidase activity//endopeptidase activity GO:0005737//GO:0019773//GO:0005839//GO:0005634 cytoplasm//proteasome core complex, alpha-subunit complex//proteasome core complex//nucleus KOG0181 20S proteasome, regulatory subunit alpha type PSMA2/PRE8 Cluster-8309.42445 BP_3 1015.52 22.35 2482 91080689 XP_975235.1 1580 9.9e-173 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [Tribolium castaneum]>gi|270006426|gb|EFA02874.1| hypothetical protein TcasGA2_TC007967 [Tribolium castaneum] 642919565 XM_970142.2 154 2.76514e-72 PREDICTED: Tribolium castaneum NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (LOC664127), mRNA K03953 NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03953 P34943 747 1.6e-77 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Bos taurus GN=NDUFA9 PE=1 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210//GO:0044237 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process//cellular metabolic process GO:0000166//GO:0003824//GO:0050662//GO:0003854//GO:0016616 nucleotide binding//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit Cluster-8309.42446 BP_3 80.00 13.66 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42448 BP_3 78.00 3.03 1533 642929701 XP_008195941.1 161 2.1e-08 PREDICTED: uncharacterized protein LOC103313715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42450 BP_3 310.00 14.76 1304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42451 BP_3 1707.58 11.92 7195 189234936 XP_971620.2 2104 5.0e-233 PREDICTED: probable sulfite oxidase, mitochondrial [Tribolium castaneum]>gi|642914911|ref|XP_008190439.1| PREDICTED: probable sulfite oxidase, mitochondrial [Tribolium castaneum]>gi|642914914|ref|XP_008190440.1| PREDICTED: probable sulfite oxidase, mitochondrial [Tribolium castaneum]>gi|270001403|gb|EEZ97850.1| hypothetical protein TcasGA2_TC000220 [Tribolium castaneum] 642914909 XM_966579.3 195 1.30565e-94 PREDICTED: Tribolium castaneum ubiquitin domain-containing protein 2 (LOC660341), mRNA K00387 SUOX sulfite oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00387 Q9VWP4 1553 1.6e-170 Probable sulfite oxidase, mitochondrial OS=Drosophila melanogaster GN=CG7280 PE=2 SV=1 PF00240//PF00174//PF01365//PF03404 Ubiquitin family//Oxidoreductase molybdopterin binding domain//RIH domain//Mo-co oxidoreductase dimerisation domain GO:0055114//GO:0006118//GO:0070588//GO:0042128//GO:0006816 oxidation-reduction process//obsolete electron transport//calcium ion transmembrane transport//nitrate assimilation//calcium ion transport GO:0020037//GO:0009055//GO:0005515//GO:0030151//GO:0016491//GO:0005262 heme binding//electron carrier activity//protein binding//molybdenum ion binding//oxidoreductase activity//calcium channel activity GO:0016020 membrane KOG0535 Sulfite oxidase, molybdopterin-binding component Cluster-8309.42455 BP_3 72.31 0.97 3873 91078068 XP_971672.1 239 4.9e-17 PREDICTED: ubiquitin domain-containing protein 2 [Tribolium castaneum]>gi|270002315|gb|EEZ98762.1| hypothetical protein TcasGA2_TC001326 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68FV8 136 1.8e-06 Ubiquitin domain-containing protein 1 OS=Rattus norvegicus GN=Ubtd1 PE=2 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42456 BP_3 76.39 1.13 3538 91092538 XP_967850.1 1519 1.7e-165 PREDICTED: ras-related GTP-binding protein A [Tribolium castaneum]>gi|270006620|gb|EFA03068.1| hypothetical protein TcasGA2_TC010924 [Tribolium castaneum] 332372815 BT126586.1 193 8.26574e-94 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q3SX43 1348 4.6e-147 Ras-related GTP-binding protein A OS=Bos taurus GN=RRAGA PE=2 SV=1 PF07516//PF00025//PF08477//PF01926//PF00503//PF00484//PF04670//PF10662//PF00071//PF00005//PF03193 SecA Wing and Scaffold domain//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//G-protein alpha subunit//Carbonic anhydrase//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//ABC transporter//Protein of unknown function, DUF258 GO:0007165//GO:0017038//GO:0007186//GO:0006730//GO:0006576//GO:0007264//GO:0006807 signal transduction//protein import//G-protein coupled receptor signaling pathway//one-carbon metabolic process//cellular biogenic amine metabolic process//small GTPase mediated signal transduction//nitrogen compound metabolic process GO:0003924//GO:0005524//GO:0031683//GO:0008270//GO:0016887//GO:0019001//GO:0004089//GO:0005525//GO:0004871 GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//zinc ion binding//ATPase activity//guanyl nucleotide binding//carbonate dehydratase activity//GTP binding//signal transducer activity GO:0005737//GO:0005634//GO:0016020 cytoplasm//nucleus//membrane KOG3886 GTP-binding protein Cluster-8309.42457 BP_3 131.24 8.48 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42459 BP_3 280.65 3.20 4519 642925855 XP_008190573.1 1338 2.1e-144 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q9VC27 807 3.2e-84 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF05450//PF00328 Nicastrin//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771//GO:0016485 hexachlorocyclohexane metabolic process//riboflavin metabolic process//protein processing GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane -- -- Cluster-8309.42460 BP_3 170.00 2.18 4059 546677536 ERL88355.1 1184 1.3e-126 hypothetical protein D910_05742 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U492 160 3.0e-09 Kielin/chordin-like protein OS=Mus musculus GN=Kcp PE=1 SV=2 PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42461 BP_3 392.00 15.87 1482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42463 BP_3 83.00 1.70 2639 642916217 XP_008190934.1 2507 3.4e-280 PREDICTED: calpain-C [Tribolium castaneum] 195479179 XM_002100759.1 39 2.49386e-08 Drosophila yakuba GE17262 (Dyak\GE17262), partial mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 Q9VXH6 1334 1.5e-145 Calpain-C OS=Drosophila melanogaster GN=CalpC PE=1 SV=4 PF13405//PF00648 EF-hand domain//Calpain family cysteine protease GO:0006508 proteolysis GO:0004198//GO:0005509 calcium-dependent cysteine-type endopeptidase activity//calcium ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.42467 BP_3 1463.16 11.05 6676 642930102 XP_008196252.1 1798 1.4e-197 PREDICTED: putative epidermal cell surface receptor isoform X3 [Tribolium castaneum] 195454384 XM_002074181.1 39 6.35419e-08 Drosophila willistoni GK14524 (Dwil\GK14524), mRNA -- -- -- -- Q04164 1079 1.4e-115 Putative epidermal cell surface receptor OS=Drosophila melanogaster GN=sas PE=2 SV=2 PF00093//PF00041//PF02556 von Willebrand factor type C domain//Fibronectin type III domain//Preprotein translocase subunit SecB GO:0015031//GO:0051262 protein transport//protein tetramerization GO:0005515//GO:0051082 protein binding//unfolded protein binding -- -- -- -- Cluster-8309.42468 BP_3 52.16 0.36 7185 642930100 XP_008196251.1 1598 2.3e-174 PREDICTED: putative epidermal cell surface receptor isoform X2 [Tribolium castaneum] 195454384 XM_002074181.1 39 6.84136e-08 Drosophila willistoni GK14524 (Dwil\GK14524), mRNA -- -- -- -- Q04164 1075 4.3e-115 Putative epidermal cell surface receptor OS=Drosophila melanogaster GN=sas PE=2 SV=2 PF16656//PF00041//PF02556//PF00093 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Preprotein translocase subunit SecB//von Willebrand factor type C domain GO:0019497//GO:0051262//GO:0015031//GO:0006771 hexachlorocyclohexane metabolic process//protein tetramerization//protein transport//riboflavin metabolic process GO:0005515//GO:0046872//GO:0051082//GO:0003993 protein binding//metal ion binding//unfolded protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.42469 BP_3 96.99 1.28 3941 642913457 XP_008201020.1 4044 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.0e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00023//PF00784 Ankyrin repeat//Ankyrin repeat//MyTH4 domain -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.42470 BP_3 62.16 0.47 6611 642926382 XP_008194902.1 3527 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Tribolium castaneum] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q505D1 2365 1.0e-264 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF02891//PF00023//PF03604//PF09066 Ankyrin repeat//MIZ/SP-RING zinc finger//Ankyrin repeat//DNA directed RNA polymerase, 7 kDa subunit//Beta2-adaptin appendage, C-terminal sub-domain GO:0006206//GO:0006886//GO:0016192//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//intracellular protein transport//vesicle-mediated transport//purine nucleobase metabolic process//transcription, DNA-templated GO:0008270//GO:0005515//GO:0003677//GO:0003899 zinc ion binding//protein binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0030131 nucleolus//clathrin adaptor complex -- -- Cluster-8309.42471 BP_3 42.43 0.74 3046 642913255 XP_008201459.1 819 2.1e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 7.20572e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.7e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.42472 BP_3 240.95 3.50 3606 91086687 XP_969129.1 2459 1.7e-274 PREDICTED: tyrosine-protein kinase Src42A isoform X2 [Tribolium castaneum] 242015483 XM_002428338.1 244 3.75742e-122 Pediculus humanus corporis tyrosine-protein kinase Src42A, putative, mRNA K08892 FRK, PTK5 fyn-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08892 Q9V9J3 2167 5.1e-242 Tyrosine-protein kinase Src42A OS=Drosophila melanogaster GN=Src42A PE=2 SV=1 PF07714//PF06293//PF00069//PF14604//PF00018 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Variant SH3 domain//SH3 domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0005515//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein binding//protein kinase activity GO:0016020 membrane KOG0197 Tyrosine kinases Cluster-8309.42473 BP_3 1793.24 20.78 4451 646718564 KDR20976.1 3498 0.0e+00 Formin-like protein, partial [Zootermopsis nevadensis] 837785995 XM_012926268.1 41 3.26762e-09 PREDICTED: Ochotona princeps formin-like 2 (FMNL2), transcript variant X2, mRNA -- -- -- -- Q9VUC6 1597 7.8e-176 Formin-like protein CG32138 OS=Drosophila melanogaster GN=CG32138 PE=1 SV=3 PF06367//PF08671//PF06371//PF02734//PF04627 Diaphanous FH3 Domain//Anti-repressor SinI//Diaphanous GTPase-binding Domain//DAK2 domain//Mitochondrial ATP synthase epsilon chain GO:0006119//GO:0016043//GO:0015986//GO:0006355//GO:0015992//GO:0006071//GO:0046486//GO:0030036 oxidative phosphorylation//cellular component organization//ATP synthesis coupled proton transport//regulation of transcription, DNA-templated//proton transport//glycerol metabolic process//glycerolipid metabolic process//actin cytoskeleton organization GO:0046983//GO:0017048//GO:0004371//GO:0003779//GO:0046933//GO:0046961 protein dimerization activity//Rho GTPase binding//glycerone kinase activity//actin binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism GO:0000275//GO:0045259 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex KOG1923 Rac1 GTPase effector FRL Cluster-8309.42474 BP_3 51.95 0.45 5864 646718564 KDR20976.1 3302 0.0e+00 Formin-like protein, partial [Zootermopsis nevadensis] 837785995 XM_012926268.1 41 4.3134e-09 PREDICTED: Ochotona princeps formin-like 2 (FMNL2), transcript variant X2, mRNA -- -- -- -- Q9VUC6 1597 1.0e-175 Formin-like protein CG32138 OS=Drosophila melanogaster GN=CG32138 PE=1 SV=3 PF02734//PF04627//PF06367//PF08671//PF06371 DAK2 domain//Mitochondrial ATP synthase epsilon chain//Diaphanous FH3 Domain//Anti-repressor SinI//Diaphanous GTPase-binding Domain GO:0015992//GO:0006071//GO:0046486//GO:0030036//GO:0006355//GO:0015986//GO:0006119//GO:0016043 proton transport//glycerol metabolic process//glycerolipid metabolic process//actin cytoskeleton organization//regulation of transcription, DNA-templated//ATP synthesis coupled proton transport//oxidative phosphorylation//cellular component organization GO:0046933//GO:0046961//GO:0004371//GO:0003779//GO:0017048//GO:0046983 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//glycerone kinase activity//actin binding//Rho GTPase binding//protein dimerization activity GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG1923 Rac1 GTPase effector FRL Cluster-8309.42475 BP_3 542.93 5.90 4726 646718564 KDR20976.1 3302 0.0e+00 Formin-like protein, partial [Zootermopsis nevadensis] 837785995 XM_012926268.1 41 3.47115e-09 PREDICTED: Ochotona princeps formin-like 2 (FMNL2), transcript variant X2, mRNA -- -- -- -- Q9VUC6 1597 8.3e-176 Formin-like protein CG32138 OS=Drosophila melanogaster GN=CG32138 PE=1 SV=3 PF06371//PF01044//PF08671//PF06367//PF04627//PF02734 Diaphanous GTPase-binding Domain//Vinculin family//Anti-repressor SinI//Diaphanous FH3 Domain//Mitochondrial ATP synthase epsilon chain//DAK2 domain GO:0006071//GO:0015992//GO:0030036//GO:0046486//GO:0006355//GO:0016043//GO:0006119//GO:0007155//GO:0015986 glycerol metabolic process//proton transport//actin cytoskeleton organization//glycerolipid metabolic process//regulation of transcription, DNA-templated//cellular component organization//oxidative phosphorylation//cell adhesion//ATP synthesis coupled proton transport GO:0004371//GO:0003779//GO:0046933//GO:0046961//GO:0051015//GO:0046983//GO:0017048 glycerone kinase activity//actin binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//actin filament binding//protein dimerization activity//Rho GTPase binding GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG1923 Rac1 GTPase effector FRL Cluster-8309.42476 BP_3 223.81 1.19 9365 478251011 ENN71492.1 1206 8.7e-129 hypothetical protein YQE_11788, partial [Dendroctonus ponderosae] -- -- -- -- -- K09592 EGLN, HPH hypoxia-inducible factor prolyl hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K09592 Q9GZT9 668 8.7e-68 Egl nine homolog 1 OS=Homo sapiens GN=EGLN1 PE=1 SV=1 PF13640 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3710 EGL-Nine (EGLN) protein Cluster-8309.42477 BP_3 6.16 0.38 1066 403234001 AFR31785.1 186 1.9e-11 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42478 BP_3 64.51 0.98 3464 546674875 ERL86161.1 2467 1.9e-275 hypothetical protein D910_03574 [Dendroctonus ponderosae] -- -- -- -- -- K12796 ERBB2IP, ERBIN erbb2-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12796 Q9V780 762 4.1e-79 Protein lap1 OS=Drosophila melanogaster GN=Lap1 PE=2 SV=1 PF13855//PF13180//PF00560//PF00595 Leucine rich repeat//PDZ domain//Leucine Rich Repeat//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.42479 BP_3 9.28 0.35 1568 156465583 ABU68110.1 1467 7.9e-160 MHC class I antigen [Macaca mulatta] 14250098 BC008457.1 1134 0 Homo sapiens major histocompatibility complex, class I, C, mRNA (cDNA clone MGC:14707 IMAGE:4249847), complete cds K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P30387 1346 3.5e-147 Class I histocompatibility antigen, Gogo-C*0203 alpha chain OS=Gorilla gorilla gorilla PE=2 SV=1 PF06623//PF00129//PF16497 MHC_I C-terminus//Class I Histocompatibility antigen, domains alpha 1 and 2//MHC-I family domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- -- -- -- -- Cluster-8309.42480 BP_3 1078.09 12.00 4622 642915302 XP_008190562.1 1564 1.3e-170 PREDICTED: JNK-interacting protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58A65 1044 1.1e-111 C-Jun-amino-terminal kinase-interacting protein 4 OS=Mus musculus GN=Spag9 PE=1 SV=2 PF01080//PF03178 Presenilin//CPSF A subunit region -- -- GO:0004190//GO:0003676 aspartic-type endopeptidase activity//nucleic acid binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.42482 BP_3 55.43 0.85 3420 546673279 ERL84915.1 371 2.1e-32 hypothetical protein D910_02338 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42483 BP_3 21.00 0.47 2459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42484 BP_3 8.72 0.55 1056 642920880 XP_008192598.1 365 3.2e-32 PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum]>gi|642920882|ref|XP_008192599.1| PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SP67 309 4.2e-27 WD repeat-containing protein 26 OS=Danio rerio GN=wdr26 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.42485 BP_3 27.72 0.33 4380 642920880 XP_008192598.1 1586 3.5e-173 PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum]>gi|642920882|ref|XP_008192599.1| PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7D7 1128 1.9e-121 WD repeat-containing protein 26 OS=Homo sapiens GN=WDR26 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.42486 BP_3 2.00 0.91 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42487 BP_3 209.05 3.81 2938 270006128 EFA02576.1 1541 3.9e-168 hypothetical protein TcasGA2_TC008294 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7D7 1128 1.2e-121 WD repeat-containing protein 26 OS=Homo sapiens GN=WDR26 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.42490 BP_3 13.91 0.31 2463 91089299 XP_971539.1 2343 3.3e-261 PREDICTED: uncharacterized protein LOC660192 [Tribolium castaneum] 642933045 XM_966446.2 324 8.62685e-167 PREDICTED: Tribolium castaneum uncharacterized LOC660192 (LOC660192), mRNA -- -- -- -- P16066 662 1.1e-67 Atrial natriuretic peptide receptor 1 OS=Homo sapiens GN=NPR1 PE=1 SV=1 PF07701//PF00211 Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain GO:0046039//GO:0006182//GO:0009190//GO:0035556//GO:0006144 GTP metabolic process//cGMP biosynthetic process//cyclic nucleotide biosynthetic process//intracellular signal transduction//purine nucleobase metabolic process GO:0004383//GO:0016849 guanylate cyclase activity//phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.42491 BP_3 513.32 11.83 2383 642925261 XP_008194484.1 311 1.3e-25 PREDICTED: ATP-dependent DNA helicase Q5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08236 SRI (Set2 Rpb1 interacting) domain GO:0006479//GO:0006355//GO:0006554//GO:0034968 protein methylation//regulation of transcription, DNA-templated//lysine catabolic process//histone lysine methylation GO:0018024 histone-lysine N-methyltransferase activity GO:0005694 chromosome -- -- Cluster-8309.42493 BP_3 1515.85 81.16 1192 91080235 XP_972829.1 892 2.9e-93 PREDICTED: caprin homolog [Tribolium castaneum]>gi|270005626|gb|EFA02074.1| hypothetical protein TcasGA2_TC007709 [Tribolium castaneum] -- -- -- -- -- K18743 CAPRIN1, GPIAP1 caprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K18743 Q9I7D3 338 2.0e-30 Caprin homolog OS=Drosophila melanogaster GN=Capr PE=1 SV=1 PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GO:0006633//GO:0006090 fatty acid biosynthetic process//pyruvate metabolic process GO:0003989 acetyl-CoA carboxylase activity GO:0009317 acetyl-CoA carboxylase complex -- -- Cluster-8309.42495 BP_3 12.40 0.34 2074 642931814 XP_008196744.1 1095 1.4e-116 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 797 2.1e-83 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.42496 BP_3 140.01 1.44 4970 817066161 XP_012254906.1 781 8.9e-80 PREDICTED: ribosomal protein S6 kinase beta-1 isoform X1 [Athalia rosae] 645004372 XM_008210703.1 107 7.46967e-46 PREDICTED: Nasonia vitripennis ribosomal protein S6 kinase beta-1-like (LOC100115857), transcript variant X3, mRNA K04688 RPS6KB p70 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04688 Q8BSK8 669 3.5e-68 Ribosomal protein S6 kinase beta-1 OS=Mus musculus GN=Rps6kb1 PE=1 SV=2 PF06293//PF00069//PF00433//PF07714//PF05180 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein kinase C terminal domain//Protein tyrosine kinase//DNL zinc finger GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004674//GO:0004672//GO:0008270//GO:0016773//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//zinc ion binding//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.42497 BP_3 32.61 0.36 4667 242008699 XP_002425139.1 360 5.5e-31 RAC protein kinase DRAC-PK85, putative [Pediculus humanus corporis]>gi|212508820|gb|EEB12401.1| RAC protein kinase DRAC-PK85, putative [Pediculus humanus corporis] -- -- -- -- -- K04688 RPS6KB p70 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04688 P67998 320 9.8e-28 Ribosomal protein S6 kinase beta-1 OS=Oryctolagus cuniculus GN=RPS6KB1 PE=2 SV=1 PF04795//PF00069//PF05180 PAPA-1-like conserved region//Protein kinase domain//DNL zinc finger GO:0007165//GO:0009069//GO:0006468//GO:0016310 signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0008270//GO:0004697//GO:0004672//GO:0005524 zinc ion binding//protein kinase C activity//protein kinase activity//ATP binding GO:0031011 Ino80 complex KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.42498 BP_3 765.50 4.37 8734 91090153 XP_972190.1 9530 0.0e+00 PREDICTED: CAD protein [Tribolium castaneum]>gi|270013749|gb|EFA10197.1| hypothetical protein TcasGA2_TC012392 [Tribolium castaneum] 218526269 EU860157.1 823 0 Strangalia bicolor carbamoyl-phosphate synthase (CAD) gene, partial cds K11540 CAD carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase http://www.genome.jp/dbget-bin/www_bget?ko:K11540 P05990 7863 0.0e+00 CAD protein OS=Drosophila melanogaster GN=r PE=1 SV=3 PF02729//PF01979//PF07478//PF02786//PF07722//PF02655//PF00185//PF00113 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain//Amidohydrolase family//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//Peptidase C26//ATP-grasp domain//Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain//Enolase, C-terminal TIM barrel domain GO:0006571//GO:0006541//GO:0006094//GO:0006207//GO:0006096//GO:0000162//GO:0006543//GO:0006807//GO:0009252//GO:0006520//GO:0009094//GO:0006206//GO:0006522//GO:0046436//GO:0006531//GO:0070409 tyrosine biosynthetic process//glutamine metabolic process//gluconeogenesis//'de novo' pyrimidine nucleobase biosynthetic process//glycolytic process//tryptophan biosynthetic process//glutamine catabolic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process//cellular amino acid metabolic process//L-phenylalanine biosynthetic process//pyrimidine nucleobase metabolic process//alanine metabolic process//D-alanine metabolic process//aspartate metabolic process//carbamoyl phosphate biosynthetic process GO:0004634//GO:0005524//GO:0016787//GO:0008716//GO:0000287//GO:0004070//GO:0046872//GO:0016597//GO:0016812//GO:0016743 phosphopyruvate hydratase activity//ATP binding//hydrolase activity//D-alanine-D-alanine ligase activity//magnesium ion binding//aspartate carbamoyltransferase activity//metal ion binding//amino acid binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides//carboxyl- or carbamoyltransferase activity GO:0009347//GO:0000015 aspartate carbamoyltransferase complex//phosphopyruvate hydratase complex KOG0370 Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) Cluster-8309.4250 BP_3 11.16 1.23 728 826494638 XP_012540802.1 405 5.1e-37 PREDICTED: pleckstrin homology domain-containing family F member 2 isoform X1 [Monomorium pharaonis] 755945962 XM_011301681.1 89 1.0663e-36 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 352 3.0e-32 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1729 FYVE finger containing protein Cluster-8309.42501 BP_3 1060.69 16.49 3392 91091602 XP_975764.1 2842 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X7 [Tribolium castaneum] 642937044 XM_970671.2 557 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X7, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 1982 1.4e-220 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF11540//PF09266//PF00400 Cytoplasmic dynein 1 intermediate chain 2//Viral DNA topoisomerase I, N-terminal//WD domain, G-beta repeat GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0005515//GO:0003916//GO:0003677 protein binding//DNA topoisomerase activity//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.42504 BP_3 125.46 3.82 1873 478262468 ENN81139.1 1449 1.2e-157 hypothetical protein YQE_02506, partial [Dendroctonus ponderosae]>gi|546672781|gb|ERL84537.1| hypothetical protein D910_01967 [Dendroctonus ponderosae] -- -- -- -- -- K14689 SLC30A2, ZNT2 solute carrier family 30 (zinc transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14689 Q2HJ10 917 2.3e-97 Zinc transporter 2 OS=Mus musculus GN=Slc30a2 PE=2 SV=1 PF01545 Cation efflux family GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1482 Zn2+ transporter Cluster-8309.42505 BP_3 170.21 3.97 2357 642918229 XP_008191421.1 1595 1.7e-174 PREDICTED: uncharacterized protein LOC100141757 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42507 BP_3 691.26 5.91 5929 91092090 XP_971602.1 1246 1.3e-133 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 Q0P678 341 4.6e-30 Zinc finger CCCH domain-containing protein 18 OS=Mus musculus GN=Zc3h18 PE=1 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.42508 BP_3 399.90 3.50 5802 91092090 XP_971602.1 1246 1.2e-133 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 Q0P678 341 4.5e-30 Zinc finger CCCH domain-containing protein 18 OS=Mus musculus GN=Zc3h18 PE=1 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- -- -- Cluster-8309.42510 BP_3 39.47 0.90 2405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42511 BP_3 288.08 2.99 4928 189240067 XP_970199.2 2407 2.5e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.25696e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 4.9e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF05480//PF07690//PF00083//PF08040 Staphylococcus haemolytic protein//Major Facilitator Superfamily//Sugar (and other) transporter//MNLL subunit GO:0009405//GO:0006118//GO:0055085 pathogenesis//obsolete electron transport//transmembrane transport GO:0003954//GO:0022857 NADH dehydrogenase activity//transmembrane transporter activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.42512 BP_3 148.47 2.93 2732 91092400 XP_969218.1 1516 2.9e-165 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 624 3.2e-63 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.42513 BP_3 20.61 0.64 1840 91092400 XP_969218.1 763 4.0e-78 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 360 8.9e-33 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.42516 BP_3 116.13 2.72 2351 189234632 XP_001815875.1 1000 1.7e-105 PREDICTED: uncharacterized protein LOC100141793 [Tribolium castaneum]>gi|270002124|gb|EEZ98571.1| hypothetical protein TcasGA2_TC001083 [Tribolium castaneum] 645023008 XM_003425366.2 61 1.30688e-20 PREDICTED: Nasonia vitripennis uncharacterized LOC100678221 (LOC100678221), transcript variant X13, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42518 BP_3 94.46 0.43 10942 270008428 EFA04876.1 9007 0.0e+00 hypothetical protein TcasGA2_TC014935 [Tribolium castaneum] -- -- -- -- -- K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 P42356 4980 0.0e+00 Phosphatidylinositol 4-kinase alpha OS=Homo sapiens GN=PI4KA PE=1 SV=3 PF00106//PF00515//PF13374//PF13414//PF00107//PF13181//PF07721//PF08240//PF00454//PF00899 short chain dehydrogenase//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Zinc-binding dehydrogenase//Tetratricopeptide repeat//Tetratricopeptide repeat//Alcohol dehydrogenase GroES-like domain//Phosphatidylinositol 3- and 4-kinase//ThiF family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0005515//GO:0008641//GO:0042802//GO:0016773 oxidoreductase activity//protein binding//small protein activating enzyme activity//identical protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0902 Phosphatidylinositol 4-kinase Cluster-8309.42519 BP_3 2434.66 203.28 869 264667459 ACY71315.1 524 9.8e-51 ribosomal protein L28 [Chrysomela tremula] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 427 7.1e-41 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-8309.42520 BP_3 667.00 109.97 584 189234118 XP_001811130.1 318 5.1e-27 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42521 BP_3 71.14 3.30 1332 189234118 XP_001811130.1 610 1.6e-60 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] 153907106 AK262902.1 41 9.60233e-10 Gryllus bimaculatus mRNA, GBcontig09763 -- -- -- -- -- -- -- -- PF05757 Oxygen evolving enhancer protein 3 (PsbQ) GO:0015979 photosynthesis GO:0005509 calcium ion binding GO:0009523//GO:0009654//GO:0019898 photosystem II//photosystem II oxygen evolving complex//extrinsic component of membrane -- -- Cluster-8309.42523 BP_3 7.61 0.65 853 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42524 BP_3 552.92 4.59 6096 642911420 XP_008199415.1 4264 0.0e+00 PREDICTED: insulin-like receptor [Tribolium castaneum]>gi|642911422|ref|XP_008199416.1| PREDICTED: insulin-like receptor [Tribolium castaneum] 887513390 KP331063.1 128 1.94419e-57 Leptinotarsa decemlineata insulin-like receptor (INR) mRNA, complete cds K04527 INSR insulin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04527 Q93105 2776 2.0e-312 Insulin-like receptor OS=Aedes aegypti GN=InR PE=2 SV=2 PF00069//PF07714//PF00757//PF00041 Protein kinase domain//Protein tyrosine kinase//Furin-like cysteine rich region//Fibronectin type III domain GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0005515//GO:0004714//GO:0004672 ATP binding//protein binding//transmembrane receptor protein tyrosine kinase activity//protein kinase activity GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.42525 BP_3 8782.92 46.75 9347 642927139 XP_008195153.1 10566 0.0e+00 PREDICTED: talin-1 isoform X1 [Tribolium castaneum]>gi|642927141|ref|XP_008195154.1| PREDICTED: talin-1 isoform X1 [Tribolium castaneum] 645021046 XM_008209207.1 107 1.40902e-45 PREDICTED: Nasonia vitripennis talin-2 (LOC100123995), mRNA K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 5938 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01608//PF02174//PF03081//PF01044//PF09141//PF01025 I/LWEQ domain//PTB domain (IRS-1 type)//Exo70 exocyst complex subunit//Vinculin family//Talin, middle domain//GrpE GO:0007155//GO:0006887//GO:0006457//GO:0007165//GO:0007016 cell adhesion//exocytosis//protein folding//signal transduction//cytoskeletal anchoring at plasma membrane GO:0042803//GO:0005200//GO:0051087//GO:0051015//GO:0000774//GO:0003779//GO:0005158 protein homodimerization activity//structural constituent of cytoskeleton//chaperone binding//actin filament binding//adenyl-nucleotide exchange factor activity//actin binding//insulin receptor binding GO:0000145//GO:0005899//GO:0001726//GO:0005856//GO:0005925 exocyst//insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.42526 BP_3 282.58 1.17 11959 642927143 XP_008195155.1 8604 0.0e+00 PREDICTED: talin-1 isoform X2 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.81714e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01608//PF09141//PF01025//PF01044//PF02174 I/LWEQ domain//Talin, middle domain//GrpE//Vinculin family//PTB domain (IRS-1 type) GO:0006457//GO:0007016//GO:0007165//GO:0007155 protein folding//cytoskeletal anchoring at plasma membrane//signal transduction//cell adhesion GO:0003779//GO:0005158//GO:0000774//GO:0051015//GO:0005200//GO:0051087//GO:0042803 actin binding//insulin receptor binding//adenyl-nucleotide exchange factor activity//actin filament binding//structural constituent of cytoskeleton//chaperone binding//protein homodimerization activity GO:0005899//GO:0005925//GO:0005856//GO:0001726 insulin receptor complex//focal adhesion//cytoskeleton//ruffle KOG0980 Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 Cluster-8309.42527 BP_3 270.77 23.42 849 189240885 XP_971484.2 983 5.7e-104 PREDICTED: splicing factor 3B subunit 1 isoform X1 [Tribolium castaneum] 642934610 XM_966391.3 152 1.19171e-71 PREDICTED: Tribolium castaneum splicing factor 3B subunit 1 (LOC660131), transcript variant X1, mRNA K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O57683 556 7.6e-56 Splicing factor 3B subunit 1 OS=Xenopus laevis GN=sf3b1 PE=2 SV=1 PF04162 Gyrovirus capsid protein (VP1) -- -- -- -- GO:0019028 viral capsid KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.42528 BP_3 17.00 1.80 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42529 BP_3 31.04 0.32 4937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.42531 BP_3 350.24 5.68 3264 642936982 XP_008198641.1 2270 1.3e-252 PREDICTED: bromodomain-containing protein 3-like isoform X4 [Tribolium castaneum] 642936987 XM_008200422.1 148 7.89335e-69 PREDICTED: Tribolium castaneum bromodomain-containing protein 3-like (LOC656325), transcript variant X11, mRNA K11721 BRD3 bromodomain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11721 Q15059 993 6.2e-106 Bromodomain-containing protein 3 OS=Homo sapiens GN=BRD3 PE=1 SV=1 PF01025//PF12761//PF08290//PF00439//PF13965 GrpE//Actin cytoskeleton-regulatory complex protein END3//Hepatitis core protein, putative zinc finger//Bromodomain//dsRNA-gated channel SID-1 GO:0015931//GO:0009405//GO:0006457//GO:0007015//GO:0006897//GO:0033227 nucleobase-containing compound transport//pathogenesis//protein folding//actin filament organization//endocytosis//dsRNA transport GO:0005198//GO:0005515//GO:0042803//GO:0051087//GO:0000774//GO:0051033 structural molecule activity//protein binding//protein homodimerization activity//chaperone binding//adenyl-nucleotide exchange factor activity//RNA transmembrane transporter activity GO:0016021 integral component of membrane KOG1474 Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins Cluster-8309.42532 BP_3 491.86 7.18 3595 642936978 XP_008198639.1 774 4.2e-79 PREDICTED: bromodomain-containing protein 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13709 137 1.2e-06 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42533 BP_3 246.14 3.55 3634 642916768 XP_008192537.1 518 2.0e-49 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V3B7 326 1.5e-28 Peptidoglycan-recognition protein SC1a/b OS=Drosophila melanogaster GN=PGRP-SC1a PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0006807//GO:0009253//GO:0009252 nitrogen compound metabolic process//peptidoglycan catabolic process//peptidoglycan biosynthetic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.42534 BP_3 261.21 3.56 3833 270013053 EFA09501.1 222 4.5e-15 hypothetical protein TcasGA2_TC011602 [Tribolium castaneum] 195578330 XM_002078983.1 42 7.81347e-10 Drosophila simulans GD23732 (Dsim\GD23732), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42535 BP_3 5069.70 52.68 4930 478255570 ENN75787.1 1084 6.4e-115 hypothetical protein YQE_07744, partial [Dendroctonus ponderosae]>gi|546682060|gb|ERL92046.1| hypothetical protein D910_09368 [Dendroctonus ponderosae] 642913709 XM_008202908.1 121 1.22239e-53 PREDICTED: Tribolium castaneum acyl-CoA desaturase 1 (LOC662865), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O00767 737 4.6e-76 Acyl-CoA desaturase OS=Homo sapiens GN=SCD PE=1 SV=2 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG1600 Fatty acid desaturase Cluster-8309.42538 BP_3 222.10 1.95 5795 270006025 EFA02473.1 1249 5.6e-134 hypothetical protein TcasGA2_TC008164 [Tribolium castaneum] -- -- -- -- -- K14803 PTC2_3 protein phosphatase 2C homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14803 P49596 1031 4.4e-110 Probable protein phosphatase 2C T23F11.1 OS=Caenorhabditis elegans GN=ppm-2 PE=3 SV=2 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.42539 BP_3 70.67 0.70 5139 642919054 XP_008191715.1 729 9.8e-74 PREDICTED: C2 domain-containing protein 3 [Tribolium castaneum] -- -- -- -- -- K16751 C2CD3 C2 domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16751 Q4AC94 264 3.4e-21 C2 domain-containing protein 3 OS=Homo sapiens GN=C2CD3 PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42540 BP_3 13.33 0.53 1501 642934430 XP_008197659.1 988 2.6e-104 PREDICTED: mitochondrial Rho GTPase isoform X1 [Tribolium castaneum] -- -- -- -- -- K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 622 3.0e-63 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 PF08477//PF07231//PF02367//PF00910 Ras of Complex, Roc, domain of DAPkinase//Hs1pro-1 N-terminus//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase GO:0007264//GO:0006952//GO:0002949 small GTPase mediated signal transduction//defense response//tRNA threonylcarbamoyladenosine modification GO:0003724//GO:0005525//GO:0003723 RNA helicase activity//GTP binding//RNA binding -- -- KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.42541 BP_3 209.79 3.14 3508 270001368 EEZ97815.1 2124 1.2e-235 hypothetical protein TcasGA2_TC000182 [Tribolium castaneum] 170046948 XM_001850953.1 142 1.83776e-65 Culex quinquefasciatus tyrosine phosphatase n9, mRNA K18038 PTPN9, MEG2 tyrosine-protein phosphatase non-receptor type 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18038 Q641Z2 948 1.1e-100 Tyrosine-protein phosphatase non-receptor type 9 OS=Rattus norvegicus GN=Ptpn9 PE=2 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.42544 BP_3 328.42 3.86 4393 91078200 XP_968428.1 1053 2.3e-111 PREDICTED: m7GpppN-mRNA hydrolase [Tribolium castaneum]>gi|270001356|gb|EEZ97803.1| hypothetical protein TcasGA2_TC000167 [Tribolium castaneum] -- -- -- -- -- K12613 DCP2 mRNA-decapping enzyme subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12613 Q5REQ8 710 5.5e-73 m7GpppN-mRNA hydrolase OS=Pongo abelii GN=DCP2 PE=2 SV=1 PF00293//PF08273//PF15957//PF05026 NUDIX domain//Zinc-binding domain of primase-helicase//Commissureless//Dcp2, box A domain GO:0007411//GO:0006351//GO:0006269 axon guidance//transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0030145//GO:0016787//GO:0003896//GO:0004386//GO:0003723//GO:0008270 manganese ion binding//hydrolase activity//DNA primase activity//helicase activity//RNA binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG2937 Decapping enzyme complex, predicted pyrophosphatase DCP2 Cluster-8309.42545 BP_3 30.00 2.43 888 170321839 BAG14264.1 445 1.4e-41 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P28175 230 5.1e-18 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.42549 BP_3 125.09 0.79 7964 625256567 XP_007619640.1 744 2.8e-75 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like, partial [Cricetulus griseus] 642912444 XM_008202641.1 83 2.63391e-32 PREDICTED: Tribolium castaneum serum response factor (Srf), transcript variant X1, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 718 1.2e-73 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF13465//PF07776//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.4255 BP_3 13.59 0.43 1809 642917255 XP_008199223.1 662 2.0e-66 PREDICTED: coiled-coil and C2 domain-containing protein 2A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CFW7 274 8.2e-23 Coiled-coil and C2 domain-containing protein 2A OS=Mus musculus GN=Cc2d2a PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42550 BP_3 42.73 1.02 2318 478255733 ENN75942.1 1725 1.4e-189 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 789 2.0e-82 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 PF05395//PF13639//PF00096//PF00097//PF08119 Protein phosphatase inhibitor 1/DARPP-32//Ring finger domain//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//Scorpion acidic alpha-KTx toxin family GO:0007165//GO:0009405//GO:0006810 signal transduction//pathogenesis//transport GO:0008270//GO:0046872//GO:0004864//GO:0019870//GO:0005515 zinc ion binding//metal ion binding//protein phosphatase inhibitor activity//potassium channel inhibitor activity//protein binding GO:0005576 extracellular region KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.42551 BP_3 202.70 0.93 10764 642937913 XP_972695.3 1638 8.1e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.5e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42553 BP_3 835.09 6.35 6634 642917203 XP_008191162.1 5579 0.0e+00 PREDICTED: protein virilizer [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AIV2 848 8.3e-89 Protein virilizer homolog OS=Mus musculus GN=Kiaa1429 PE=1 SV=1 PF00665//PF01529 Integrase core domain//DHHC palmitoyltransferase GO:0015074 DNA integration GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.42555 BP_3 53.35 0.33 8065 91079606 XP_966371.1 987 1.9e-103 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|642917676|ref|XP_008191323.1| PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270003388|gb|EEZ99835.1| hypothetical protein TcasGA2_TC002616 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 442 1.2e-41 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 PF14659//PF02170//PF03798//PF04138//PF16588 Phage integrase, N-terminal SAM-like domain//PAZ domain//TLC domain//GtrA-like protein//C2H2 zinc-finger GO:0000271//GO:0006810//GO:0015074 polysaccharide biosynthetic process//transport//DNA integration GO:0003677//GO:0005515//GO:0003676//GO:0008270 DNA binding//protein binding//nucleic acid binding//zinc ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1304 Amino acid transporters Cluster-8309.4256 BP_3 63.39 2.54 1493 189242300 XP_001811434.1 777 7.7e-80 PREDICTED: bone morphogenetic protein 7 [Tribolium castaneum]>gi|270015437|gb|EFA11885.1| maverick [Tribolium castaneum] -- -- -- -- -- K04384 TGFBN transforming growth factor beta, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K04384 P20722 183 2.4e-12 Bone morphogenetic protein 6 OS=Mus musculus GN=Bmp6 PE=1 SV=2 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity -- -- -- -- Cluster-8309.42560 BP_3 481.99 6.92 3647 478253263 ENN73634.1 2771 1.1e-310 hypothetical protein YQE_09881, partial [Dendroctonus ponderosae] -- -- -- -- -- K00771 XYLT protein xylosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00771 Q5QQ53 2068 1.6e-230 Xylosyltransferase oxt OS=Drosophila pseudoobscura pseudoobscura GN=oxt PE=2 SV=1 PF02485//PF12529 Core-2/I-Branching enzyme//Xylosyltransferase C terminal GO:0030206//GO:0006024 chondroitin sulfate biosynthetic process//glycosaminoglycan biosynthetic process GO:0030158//GO:0008375 protein xylosyltransferase activity//acetylglucosaminyltransferase activity GO:0016020 membrane KOG0799 Branching enzyme Cluster-8309.42561 BP_3 214.09 6.59 1857 332377013 AEE63646.1 1214 2.0e-130 unknown [Dendroctonus ponderosae]>gi|478253342|gb|ENN73703.1| hypothetical protein YQE_09700, partial [Dendroctonus ponderosae]>gi|546673935|gb|ERL85446.1| hypothetical protein D910_02865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VD07 264 1.2e-21 Neuronal membrane glycoprotein M6-a OS=Bos taurus GN=GPM6A PE=2 SV=1 PF01275 Myelin proteolipid protein (PLP or lipophilin) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42562 BP_3 614.37 14.31 2361 332377013 AEE63646.1 1104 1.5e-117 unknown [Dendroctonus ponderosae]>gi|478253342|gb|ENN73703.1| hypothetical protein YQE_09700, partial [Dendroctonus ponderosae]>gi|546673935|gb|ERL85446.1| hypothetical protein D910_02865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VD07 261 3.4e-21 Neuronal membrane glycoprotein M6-a OS=Bos taurus GN=GPM6A PE=2 SV=1 PF01275 Myelin proteolipid protein (PLP or lipophilin) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42564 BP_3 142.00 13.63 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42565 BP_3 94.51 2.45 2149 728416984 AIY68330.1 1408 7.6e-153 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 642 2.1e-65 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.42567 BP_3 1737.14 24.39 3725 642923468 XP_008193757.1 632 1.3e-62 PREDICTED: glia maturation factor beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49858 457 1.0e-43 Protein cornichon OS=Drosophila melanogaster GN=cni PE=1 SV=1 PF00241//PF03311 Cofilin/tropomyosin-type actin-binding protein//Cornichon protein GO:0035556 intracellular signal transduction GO:0003779 actin binding GO:0016020//GO:0005622 membrane//intracellular KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.42568 BP_3 113.72 10.98 791 478252109 ENN72540.1 517 5.8e-50 hypothetical protein YQE_10880, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.42569 BP_3 57.42 1.07 2879 189238377 XP_001808976.1 1154 2.9e-123 PREDICTED: uncharacterized protein LOC100141756 [Tribolium castaneum]>gi|270008562|gb|EFA05010.1| hypothetical protein TcasGA2_TC015091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42570 BP_3 37.80 0.68 2979 189238377 XP_001808976.1 927 6.2e-97 PREDICTED: uncharacterized protein LOC100141756 [Tribolium castaneum]>gi|270008562|gb|EFA05010.1| hypothetical protein TcasGA2_TC015091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42571 BP_3 161.29 1.11 7269 642935386 XP_008197990.1 2226 3.6e-247 PREDICTED: histone acetyltransferase KAT7 [Tribolium castaneum] -- -- -- -- -- K11307 MYST2, HBO1, KAT7 histone acetyltransferase MYST2 http://www.genome.jp/dbget-bin/www_bget?ko:K11307 Q810T5 1269 1.4e-137 Histone acetyltransferase KAT7 OS=Rattus norvegicus GN=Kat7 PE=2 SV=1 PF01530//PF01853//PF13508 Zinc finger, C2HC type//MOZ/SAS family//Acetyltransferase (GNAT) domain GO:0042967//GO:0006355 acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0008080//GO:0003700//GO:0016747//GO:0008270 N-acetyltransferase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.42572 BP_3 84.18 4.23 1252 755893212 XP_011295172.1 147 7.3e-07 PREDICTED: uncharacterized protein LOC105262278 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42573 BP_3 2.00 1.40 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42574 BP_3 6.00 0.44 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42575 BP_3 1.00 0.98 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42577 BP_3 8.00 2.63 438 607368123 EZA62240.1 141 1.3e-06 hypothetical protein X777_00608 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42578 BP_3 425.58 8.18 2800 780649216 XP_011689959.1 1310 2.3e-141 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.42581 BP_3 380.06 1.68 11203 270014366 EFA10814.1 2723 1.3e-304 hypothetical protein TcasGA2_TC030632 [Tribolium castaneum] 462321141 APGK01043373.1 66 1.04626e-22 Dendroctonus ponderosae Seq01043383, whole genome shotgun sequence K11984 SART1, HAF, SNU66 U4/U6.U5 tri-snRNP-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11984 O43290 908 1.5e-95 U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens GN=SART1 PE=1 SV=1 PF00569//PF00856//PF00628//PF01033//PF03343//PF03412//PF07496 Zinc finger, ZZ type//SET domain//PHD-finger//Somatomedin B domain//SART-1 family//Peptidase C39 family//CW-type Zinc Finger GO:0006508//GO:0006955//GO:0000398//GO:0007165 proteolysis//immune response//mRNA splicing, via spliceosome//signal transduction GO:0008270//GO:0030247//GO:0008233//GO:0005524//GO:0005044//GO:0005515 zinc ion binding//polysaccharide binding//peptidase activity//ATP binding//scavenger receptor activity//protein binding GO:0016021 integral component of membrane KOG2217 U4/U6.U5 snRNP associated protein Cluster-8309.42584 BP_3 374.11 6.27 3167 91085723 XP_973304.1 1054 1.2e-111 PREDICTED: [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Tribolium castaneum]>gi|270010109|gb|EFA06557.1| hypothetical protein TcasGA2_TC009468 [Tribolium castaneum] -- -- -- -- -- K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00898 P91622 713 1.8e-73 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 PF00942 Cellulose binding domain GO:0005975 carbohydrate metabolic process GO:0005524//GO:0030248 ATP binding//cellulose binding -- -- KOG0787 Dehydrogenase kinase Cluster-8309.42585 BP_3 715.37 28.73 1492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42586 BP_3 318.63 4.37 3805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42587 BP_3 94.77 3.56 1573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42588 BP_3 105.39 1.66 3361 270001283 EEZ97730.1 2674 1.9e-299 stumps [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.9e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0005801//GO:0016020 cis-Golgi network//membrane -- -- Cluster-8309.42589 BP_3 2970.31 38.62 3999 91077584 XP_973097.1 4110 0.0e+00 PREDICTED: disintegrin and metalloproteinase domain-containing protein 10 [Tribolium castaneum] 817210687 XM_012426021.1 362 0 PREDICTED: Orussus abietinus disintegrin and metalloproteinase domain-containing protein 10 (LOC105700306), mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O14672 1111 1.6e-119 Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens GN=ADAM10 PE=1 SV=1 PF01562//PF01421 Reprolysin family propeptide//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.4259 BP_3 56.00 2.32 1453 478253177 ENN73548.1 260 6.7e-20 hypothetical protein YQE_09799, partial [Dendroctonus ponderosae]>gi|546678929|gb|ERL89467.1| hypothetical protein D910_06833 [Dendroctonus ponderosae] -- -- -- -- -- K15693 RNF26 RING finger protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K15693 Q8BUH7 177 1.2e-11 Ring finger protein 26 OS=Mus musculus GN=Rnf26 PE=2 SV=1 PF14634//PF13639 zinc-RING finger domain//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG4265 Predicted E3 ubiquitin ligase Cluster-8309.42590 BP_3 911.94 9.90 4732 642933145 XP_008197275.1 2062 2.4e-228 PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum]>gi|642933147|ref|XP_008197277.1| PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum] 642933146 XM_008199055.1 284 2.87126e-144 PREDICTED: Tribolium castaneum extracellular serine/threonine protein kinase FAM20C (LOC662687), transcript variant X2, mRNA -- -- -- -- A4VCL2 1487 4.7e-163 Extracellular serine/threonine protein CG31145 OS=Drosophila melanogaster GN=CG31145 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3829 Uncharacterized conserved protein Cluster-8309.42591 BP_3 20.15 0.45 2469 478259232 ENN79134.1 1543 1.9e-168 hypothetical protein YQE_04320, partial [Dendroctonus ponderosae] 462360259 APGK01029452.1 248 1.53141e-124 Dendroctonus ponderosae Seq01029462, whole genome shotgun sequence K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 Q95ZS2 1131 4.7e-122 Tyrosine decarboxylase OS=Caenorhabditis elegans GN=tdc-1 PE=2 SV=1 PF00282//PF04655 Pyridoxal-dependent decarboxylase conserved domain//Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0019748//GO:0006468//GO:0019752 secondary metabolic process//protein phosphorylation//carboxylic acid metabolic process GO:0016773//GO:0016831//GO:0030170 phosphotransferase activity, alcohol group as acceptor//carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.42592 BP_3 1529.01 21.47 3724 91091542 XP_970835.1 1754 9.9e-193 PREDICTED: retinal dehydrogenase 1 [Tribolium castaneum]>gi|270000922|gb|EEZ97369.1| hypothetical protein TcasGA2_TC011192 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 Q66HF8 1393 3.0e-152 Aldehyde dehydrogenase X, mitochondrial OS=Rattus norvegicus GN=Aldh1b1 PE=1 SV=1 PF00705//PF00171 Proliferating cell nuclear antigen, N-terminal domain//Aldehyde dehydrogenase family GO:0055114//GO:0008152//GO:0006275 oxidation-reduction process//metabolic process//regulation of DNA replication GO:0016491//GO:0016620//GO:0003677 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//DNA binding -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.42593 BP_3 1058.77 13.29 4132 91092680 XP_971368.1 4473 0.0e+00 PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911362|ref|XP_008199390.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911364|ref|XP_008199391.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911366|ref|XP_008199393.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|270014815|gb|EFA11263.1| hypothetical protein TcasGA2_TC010798 [Tribolium castaneum] 815809952 XM_012370439.1 590 0 PREDICTED: Linepithema humile AP-2 complex subunit alpha (LOC105674243), transcript variant X2, mRNA K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q7QG73 3987 0.0e+00 AP-2 complex subunit alpha OS=Anopheles gambiae GN=alpha-Adaptin PE=3 SV=4 PF09090//PF02985//PF02883//PF02296//PF01602 MIF4G like//HEAT repeat//Adaptin C-terminal domain//Alpha adaptin AP2, C-terminal domain//Adaptin N terminal region GO:0015031//GO:0016192//GO:0006886//GO:0016070 protein transport//vesicle-mediated transport//intracellular protein transport//RNA metabolic process GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.42594 BP_3 923.69 7.51 6222 91077030 XP_967400.1 1894 9.7e-209 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1086 2.0e-116 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF07714//PF03604//PF05028//PF01029//PF00069//PF06293//PF13971 Protein tyrosine kinase//DNA directed RNA polymerase, 7 kDa subunit//Poly (ADP-ribose) glycohydrolase (PARG)//NusB family//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Meiosis-specific protein Mei4 GO:0006144//GO:0006351//GO:0042138//GO:0006206//GO:0006310//GO:0006468//GO:0005975//GO:0006355 purine nucleobase metabolic process//transcription, DNA-templated//meiotic DNA double-strand break formation//pyrimidine nucleobase metabolic process//DNA recombination//protein phosphorylation//carbohydrate metabolic process//regulation of transcription, DNA-templated GO:0003677//GO:0003723//GO:0004649//GO:0004672//GO:0016773//GO:0003899//GO:0005524 DNA binding//RNA binding//poly(ADP-ribose) glycohydrolase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//DNA-directed RNA polymerase activity//ATP binding GO:0016020//GO:0005730 membrane//nucleolus KOG3087 Serine/threonine protein kinase Cluster-8309.42595 BP_3 389.68 4.70 4288 751449723 XP_011179103.1 1336 3.4e-144 PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae]>gi|751449725|ref|XP_011179105.1| PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae]>gi|751449727|ref|XP_011179106.1| PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae]>gi|751449729|ref|XP_011179107.1| PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae] -- -- -- -- -- K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 991 1.4e-105 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF00155//PF01053//PF00346//PF03943//PF09302 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//TAP C-terminal domain//XLF-Cernunnos, XRcc4-like factor, NHEJ component GO:0051028//GO:0055114//GO:0006302//GO:0009058 mRNA transport//oxidation-reduction process//double-strand break repair//biosynthetic process GO:0030170//GO:0051287//GO:0016651//GO:0048038 pyridoxal phosphate binding//NAD binding//oxidoreductase activity, acting on NAD(P)H//quinone binding GO:0005634 nucleus KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.42596 BP_3 230.49 7.37 1799 546685375 ERL94893.1 766 1.8e-78 hypothetical protein D910_12166 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09302 XLF-Cernunnos, XRcc4-like factor, NHEJ component GO:0006302 double-strand break repair -- -- GO:0005634 nucleus -- -- Cluster-8309.42597 BP_3 49.64 0.52 4875 751449723 XP_011179103.1 1321 2.1e-142 PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae]>gi|751449725|ref|XP_011179105.1| PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae]>gi|751449727|ref|XP_011179106.1| PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae]>gi|751449729|ref|XP_011179107.1| PREDICTED: kynurenine--oxoglutarate transaminase 3 isoform X2 [Bactrocera cucurbitae] -- -- -- -- -- K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 978 5.1e-104 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF00155//PF01053//PF00346//PF09302//PF03943 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//XLF-Cernunnos, XRcc4-like factor, NHEJ component//TAP C-terminal domain GO:0055114//GO:0006302//GO:0009058//GO:0051028 oxidation-reduction process//double-strand break repair//biosynthetic process//mRNA transport GO:0048038//GO:0030170//GO:0051287//GO:0016651 quinone binding//pyridoxal phosphate binding//NAD binding//oxidoreductase activity, acting on NAD(P)H GO:0005634 nucleus KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.42598 BP_3 522.00 12.22 2350 91091730 XP_967397.1 826 2.5e-85 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270001070|gb|EEZ97517.1| hypothetical protein TcasGA2_TC011362 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42599 BP_3 772.23 9.21 4334 478261169 ENN80698.1 3064 0.0e+00 hypothetical protein YQE_02881, partial [Dendroctonus ponderosae] 549438548 KC282406.1 75 4.0001e-28 Leptinotarsa decemlineata clone 13-6555 heat shock protein mRNA, partial cds K09486 HYOU1 hypoxia up-regulated 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09486 Q9JKR6 1864 8.3e-207 Hypoxia up-regulated protein 1 OS=Mus musculus GN=Hyou1 PE=1 SV=1 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0104 Molecular chaperones GRP170/SIL1, HSP70 superfamily Cluster-8309.426 BP_3 8.00 16.55 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42600 BP_3 334.40 9.80 1937 642918045 XP_008198993.1 411 2.8e-37 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VII6 224 5.5e-17 Choline transporter-like protein 1 OS=Rattus norvegicus GN=Slc44a1 PE=1 SV=1 PF05786//PF00063 Condensin complex subunit 2//Myosin head (motor domain) GO:0007076 mitotic chromosome condensation GO:0005524//GO:0003774 ATP binding//motor activity GO:0000796//GO:0016459 condensin complex//myosin complex KOG1362 Choline transporter-like protein Cluster-8309.42607 BP_3 124.66 1.37 4672 642919577 XP_008191928.1 3192 0.0e+00 PREDICTED: heat shock 70 kDa protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09485 HSP110 heat shock protein 110kDa http://www.genome.jp/dbget-bin/www_bget?ko:K09485 Q61316 1861 2.0e-206 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 PF02862//PF06723//PF04355 DDHD domain//MreB/Mbl protein//SmpA / OmlA family GO:0000902 cell morphogenesis GO:0046872 metal ion binding GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.42608 BP_3 1019.64 8.95 5783 189240885 XP_971484.2 5613 0.0e+00 PREDICTED: splicing factor 3B subunit 1 isoform X1 [Tribolium castaneum] 347963318 XM_310958.5 1205 0 Anopheles gambiae str. PEST AGAP000178-PA (AgaP_AGAP000178) mRNA, complete cds K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O75533 4878 0.0e+00 Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 PF07571//PF04162//PF08064//PF04931//PF02985 TAF6 C-terminal HEAT repeat domain//Gyrovirus capsid protein (VP1)//UME (NUC010) domain//DNA polymerase phi//HEAT repeat GO:0006351//GO:0016310//GO:0051090//GO:0009069//GO:0006260 transcription, DNA-templated//phosphorylation//regulation of sequence-specific DNA binding transcription factor activity//serine family amino acid metabolic process//DNA replication GO:0003677//GO:0003887//GO:0005515//GO:0004674 DNA binding//DNA-directed DNA polymerase activity//protein binding//protein serine/threonine kinase activity GO:0019028//GO:0005634//GO:0042575 viral capsid//nucleus//DNA polymerase complex KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.42610 BP_3 309.62 3.43 4648 91080629 XP_974349.1 945 8.0e-99 PREDICTED: tetraspanin-9 [Tribolium castaneum]>gi|270005823|gb|EFA02271.1| hypothetical protein TcasGA2_TC007935 [Tribolium castaneum] 5628 X01518.1 48 4.38441e-13 Acyrthosiphon magnoliae (aphid) 5S ribosomal RNA K17350 TSPAN9 tetraspanin-9 http://www.genome.jp/dbget-bin/www_bget?ko:K17350 B0BM39 415 9.4e-39 Tetraspanin-9 OS=Xenopus tropicalis GN=tspan9 PE=2 SV=1 PF06687//PF00335//PF02949 SUR7/PalI family//Tetraspanin family//7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane -- -- Cluster-8309.42614 BP_3 10.00 0.54 1184 642915997 XP_008190849.1 672 9.2e-68 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2ASS6 162 5.2e-10 Titin OS=Mus musculus GN=Ttn PE=1 SV=1 PF15185//PF13895 Bcl-2-modifying factor, apoptosis//Immunoglobulin domain GO:0006915 apoptotic process GO:0005515 protein binding -- -- -- -- Cluster-8309.42615 BP_3 16.17 0.59 1608 91080851 XP_971681.1 511 5.8e-49 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005416|gb|EFA01864.1| hypothetical protein TcasGA2_TC007467 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 352 6.5e-32 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF00437//PF02421//PF00005//PF03193//PF01637//PF13304//PF01926 Type II/IV secretion system protein//Ferrous iron transport protein B//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006200//GO:0006810//GO:0015684 obsolete ATP catabolic process//transport//ferrous iron transport GO:0005524//GO:0015093//GO:0003924//GO:0016887//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.42617 BP_3 189.00 3.75 2723 642918930 XP_008191661.1 1897 1.9e-209 PREDICTED: B-box type zinc finger protein ncl-1-like isoform X1 [Tribolium castaneum]>gi|642918932|ref|XP_008191662.1| PREDICTED: B-box type zinc finger protein ncl-1-like isoform X1 [Tribolium castaneum]>gi|642918934|ref|XP_008191663.1| PREDICTED: B-box type zinc finger protein ncl-1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64127 269 4.7e-22 Transcription intermediary factor 1-alpha OS=Mus musculus GN=Trim24 PE=1 SV=1 PF00097//PF14634//PF01363//PF00643//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//FYVE zinc finger//B-box zinc finger//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005622 intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.42619 BP_3 18.34 0.34 2889 332374366 AEE62324.1 456 2.5e-42 unknown [Dendroctonus ponderosae] 701373554 XM_009988747.1 54 1.25297e-16 PREDICTED: Tauraco erythrolophus DNA-damage inducible 1 homolog 2 (S. cerevisiae) (DDI2), partial mRNA K11885 DDI1 DNA damage-inducible protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11885 Q6TH22 295 4.8e-25 Protein DDI1 homolog 2 OS=Danio rerio GN=ddi2 PE=2 SV=1 PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG0012 DNA damage inducible protein Cluster-8309.42620 BP_3 183.52 3.87 2575 546680966 ERL91140.1 559 2.5e-54 hypothetical protein D910_08480 [Dendroctonus ponderosae] 642937909 XM_008202132.1 89 3.90137e-36 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 397 6.3e-37 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.42623 BP_3 6.60 0.36 1176 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42625 BP_3 2100.99 27.20 4015 91079794 XP_966414.1 2188 5.1e-243 PREDICTED: tyrosine-protein kinase Src64B [Tribolium castaneum]>gi|642918199|ref|XP_008191407.1| PREDICTED: tyrosine-protein kinase Src64B [Tribolium castaneum] 158295963 XM_316537.3 333 1.40336e-171 Anopheles gambiae str. PEST AGAP006510-PA (AgaP_AGAP006510) mRNA, complete cds K05704 SRC tyrosine-protein kinase Src http://www.genome.jp/dbget-bin/www_bget?ko:K05704 P00528 1938 2.0e-215 Tyrosine-protein kinase Src64B OS=Drosophila melanogaster GN=Src64B PE=1 SV=3 PF07714//PF14604//PF00018//PF00069 Protein tyrosine kinase//Variant SH3 domain//SH3 domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- -- -- Cluster-8309.42626 BP_3 65.06 0.45 7196 91090320 XP_972446.1 2561 5.1e-286 PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|642934930|ref|XP_008197867.1| PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|270013809|gb|EFA10257.1| hypothetical protein TcasGA2_TC012457 [Tribolium castaneum] 642934932 XM_967353.2 685 0 PREDICTED: Tribolium castaneum rho-related BTB domain-containing protein 2 (LOC661174), transcript variant X3, mRNA K07868 RHOBTB1_2 Rho-related BTB domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07868 Q9DAK3 906 1.7e-95 Rho-related BTB domain-containing protein 1 OS=Mus musculus GN=Rhobtb1 PE=1 SV=2 PF00651//PF08477//PF00071 BTB/POZ domain//Ras of Complex, Roc, domain of DAPkinase//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0005515 GTP binding//protein binding GO:0005622 intracellular -- -- Cluster-8309.42627 BP_3 20511.00 472.06 2386 478253496 ENN73823.1 1643 4.7e-180 hypothetical protein YQE_09601, partial [Dendroctonus ponderosae]>gi|546679122|gb|ERL89627.1| hypothetical protein D910_06992 [Dendroctonus ponderosae] 642937401 XM_963712.3 458 0 PREDICTED: Tribolium castaneum innexin inx2 (LOC657243), mRNA -- -- -- -- Q9XYN1 1557 1.8e-171 Innexin inx2 OS=Schistocerca americana GN=inx2 PE=1 SV=1 PF00839//PF00876 Cysteine rich repeat//Innexin -- -- -- -- GO:0005921//GO:0016020 gap junction//membrane -- -- Cluster-8309.42629 BP_3 1973.01 11.76 8377 642923695 XP_008193847.1 5580 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 1636 4.4e-180 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF03361//PF15723 Herpes virus intermediate/early protein 2/3//Motility quorum-sensing regulator, toxin of MqsA GO:0017148//GO:0042710//GO:0009372//GO:0006355 negative regulation of translation//biofilm formation//quorum sensing//regulation of transcription, DNA-templated -- -- -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.42630 BP_3 2159.43 89.86 1450 91091412 XP_973980.1 450 6.2e-42 PREDICTED: cAMP-responsive element-binding protein-like 2 [Tribolium castaneum]>gi|270014172|gb|EFA10620.1| hypothetical protein TcasGA2_TC012882 [Tribolium castaneum] 751781411 XM_011201569.1 47 4.83962e-13 PREDICTED: Bactrocera dorsalis cAMP-responsive element-binding protein-like 2 (LOC105223754), mRNA -- -- -- -- A4IGK3 292 5.4e-25 cAMP-responsive element-binding protein-like 2 OS=Xenopus tropicalis GN=crebl2 PE=3 SV=1 PF00170//PF07716 bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42631 BP_3 41.72 0.47 4547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10729 Cell division activator CedA GO:0051301 cell division GO:0003677 DNA binding -- -- -- -- Cluster-8309.42633 BP_3 341.00 6.18 2951 642930769 XP_973375.2 3260 0.0e+00 PREDICTED: calpain-9-like [Tribolium castaneum] 662186924 XM_008486331.1 234 1.1113e-116 PREDICTED: Diaphorina citri calpain-3-like (LOC103521221), mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 O35920 971 2.0e-103 Calpain-9 OS=Rattus norvegicus GN=Capn9 PE=2 SV=2 PF00648//PF10403 Calpain family cysteine protease//Rad4 beta-hairpin domain 1 GO:0006508 proteolysis GO:0003677//GO:0004198 DNA binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.42635 BP_3 3975.81 105.33 2111 642934971 XP_008196003.1 1022 4.3e-108 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 142 1.09919e-65 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA -- -- -- -- -- -- -- -- PF03872 Anti sigma-E protein RseA, N-terminal domain -- -- GO:0016989 sigma factor antagonist activity -- -- -- -- Cluster-8309.42636 BP_3 2.00 0.45 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42638 BP_3 28.45 0.41 3677 91094203 XP_971608.1 1093 4.3e-116 PREDICTED: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [Tribolium castaneum]>gi|270010912|gb|EFA07360.1| hypothetical protein TcasGA2_TC015960 [Tribolium castaneum] 826492697 XM_012684964.1 53 5.75119e-16 PREDICTED: Monomorium pharaonis probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (LOC105838989), mRNA K03847 ALG12 alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03847 Q9VH78 756 2.1e-78 Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster GN=CG8412 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) Cluster-8309.4264 BP_3 14.00 1.12 893 642930046 XP_008196226.1 378 8.5e-34 PREDICTED: uncharacterized protein LOC103313807 [Tribolium castaneum]>gi|270009443|gb|EFA05891.1| hypothetical protein TcasGA2_TC008703 [Tribolium castaneum] -- -- -- -- -- K15259 PARP7S poly http://www.genome.jp/dbget-bin/www_bget?ko:K15259 Q9H0J9 241 2.7e-19 Poly [ADP-ribose] polymerase 12 OS=Homo sapiens GN=PARP12 PE=1 SV=1 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- -- -- Cluster-8309.42641 BP_3 247.90 3.00 4270 91080723 XP_975387.1 919 7.6e-96 PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919596|ref|XP_008191933.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919599|ref|XP_008191934.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|270005868|gb|EFA02316.1| hypothetical protein TcasGA2_TC007982 [Tribolium castaneum] -- -- -- -- -- K16779 RAB3IP, RABIN8 Rab-3A-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K16779 Q2KJ58 289 3.5e-24 Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus GN=RAB3IL1 PE=2 SV=1 PF02926//PF06008 THUMP domain//Laminin Domain I GO:0045995//GO:0007165//GO:0030155//GO:0030334 regulation of embryonic development//signal transduction//regulation of cell adhesion//regulation of cell migration GO:0005102//GO:0003723 receptor binding//RNA binding -- -- -- -- Cluster-8309.42642 BP_3 19.49 0.47 2280 270012045 EFA08493.1 549 3.2e-53 hypothetical protein TcasGA2_TC006145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14736//PF03175 Protein N-terminal asparagine amidohydrolase//DNA polymerase type B, organellar and viral GO:0006260//GO:0006528 DNA replication//asparagine metabolic process GO:0000166//GO:0008418//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//protein-N-terminal asparagine amidohydrolase activity//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.42645 BP_3 33.89 0.69 2668 642916256 XP_008190949.1 1280 6.5e-138 PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum]>gi|642916258|ref|XP_008190950.1| PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.9e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.42646 BP_3 332.42 9.24 2026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02443 Circovirus capsid protein GO:0019069 viral capsid assembly -- -- GO:0042025 host cell nucleus -- -- Cluster-8309.42647 BP_3 68.60 0.88 4037 646717218 KDR20164.1 788 1.1e-80 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 1.28362e-57 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 2.5e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF00313 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.42648 BP_3 130.04 1.14 5799 270003434 EEZ99881.1 5332 0.0e+00 hypothetical protein TcasGA2_TC002665 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.16925e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.1e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF13414//PF02376//PF00004//PF13606//PF01637//PF07728//PF00023 TPR repeat//CUT domain//ATPase family associated with various cellular activities (AAA)//Ankyrin repeat//Archaeal ATPase//AAA domain (dynein-related subfamily)//Ankyrin repeat -- -- GO:0016887//GO:0003677//GO:0005524//GO:0005515 ATPase activity//DNA binding//ATP binding//protein binding -- -- -- -- Cluster-8309.42649 BP_3 43.64 0.61 3713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42650 BP_3 1195.00 24.59 2634 642923088 XP_972752.2 1457 1.9e-158 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 1119 1.2e-120 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00927//PF00868 Transglutaminase family, C-terminal ig like domain//Transglutaminase family GO:0018149 peptide cross-linking GO:0003810 protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.42651 BP_3 273.60 1.49 9154 642922965 XP_008200471.1 8326 0.0e+00 PREDICTED: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1 [Tribolium castaneum] 642922966 XM_008202250.1 1408 0 PREDICTED: Tribolium castaneum probable ubiquitin carboxyl-terminal hydrolase FAF-X (LOC661487), transcript variant X2, mRNA K11840 USP9_24 ubiquitin carboxyl-terminal hydrolase 9/24 http://www.genome.jp/dbget-bin/www_bget?ko:K11840 Q93008 5006 0.0e+00 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens GN=USP9X PE=1 SV=3 PF11093//PF00443 Mitochondrial export protein Som1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG1866 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.42652 BP_3 758.79 4.05 9311 642922965 XP_008200471.1 11133 0.0e+00 PREDICTED: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1 [Tribolium castaneum] 642922964 XM_008202249.1 1875 0 PREDICTED: Tribolium castaneum probable ubiquitin carboxyl-terminal hydrolase FAF-X (LOC661487), transcript variant X1, mRNA K11840 USP9_24 ubiquitin carboxyl-terminal hydrolase 9/24 http://www.genome.jp/dbget-bin/www_bget?ko:K11840 P70398 6863 0.0e+00 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Mus musculus GN=Usp9x PE=1 SV=2 PF11093//PF00443 Mitochondrial export protein Som1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG1866 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.42654 BP_3 1.00 35.97 213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42655 BP_3 60.30 0.36 8380 189241728 XP_966529.2 2097 3.8e-232 PREDICTED: polycomb protein Scm [Tribolium castaneum] 817209209 XM_012425227.1 101 2.73319e-42 PREDICTED: Orussus abietinus polycomb protein Scm-like (LOC105699853), transcript variant X3, mRNA K11461 SCMH1 polycomb protein SCMH1 http://www.genome.jp/dbget-bin/www_bget?ko:K11461 Q9VHA0 1384 7.4e-151 Polycomb protein Scm OS=Drosophila melanogaster GN=Scm PE=1 SV=2 PF06467//PF02069//PF02820 MYM-type Zinc finger with FCS sequence motif//Prokaryotic metallothionein//mbt repeat GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.42657 BP_3 4374.20 46.71 4805 642918923 XP_008191658.1 5223 0.0e+00 PREDICTED: pyruvate carboxylase, mitochondrial isoform X1 [Tribolium castaneum] 817070062 XM_012401613.1 189 1.88357e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 4044 0.0e+00 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF07478//PF02786//PF02655//PF05896//PF00682 D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//ATP-grasp domain//Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//HMGL-like GO:0009252//GO:0055114//GO:0006118//GO:0006814//GO:0046436 peptidoglycan biosynthetic process//oxidation-reduction process//obsolete electron transport//sodium ion transport//D-alanine metabolic process GO:0046872//GO:0016655//GO:0008716//GO:0005524//GO:0003824 metal ion binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//D-alanine-D-alanine ligase activity//ATP binding//catalytic activity -- -- KOG0369 Pyruvate carboxylase Cluster-8309.42658 BP_3 73.25 1.19 3265 642924817 XP_008194053.1 2123 1.4e-235 PREDICTED: nuclear receptor coactivator 7 isoform X5 [Tribolium castaneum] 749755570 XM_011141969.1 132 6.1908e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 4.1e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.4266 BP_3 2.00 0.62 446 847038947 XP_012806737.1 615 1.4e-61 PREDICTED: proteasome subunit alpha type-2 [Jaculus jaculus] 694920742 XM_528026.5 434 0 PREDICTED: Pan troglodytes proteasome (prosome, macropain) subunit, alpha type, 2 (PSMA2), mRNA K02726 PSMA2 20S proteasome subunit alpha 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02726 P25787 615 5.8e-63 Proteasome subunit alpha type-2 OS=Homo sapiens GN=PSMA2 PE=1 SV=2 PF00227//PF09010 Proteasome subunit//Anti-Sigma Factor A GO:0006355//GO:0051603 regulation of transcription, DNA-templated//proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0181 20S proteasome, regulatory subunit alpha type PSMA2/PRE8 Cluster-8309.42660 BP_3 67.58 0.92 3827 827556941 XP_012549781.1 1539 8.7e-168 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42661 BP_3 475.12 9.79 2631 642918049 XP_008198995.1 2146 2.5e-238 PREDICTED: ATP-dependent RNA helicase dbp2-like [Tribolium castaneum] 805818946 XM_012294241.1 266 1.61039e-134 PREDICTED: Megachile rotundata probable ATP-dependent RNA helicase DDX17 (LOC100881729), transcript variant X7, mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q92841 1687 1.7e-186 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.42664 BP_3 377.43 2.41 7827 170286893 BAG13448.1 5824 0.0e+00 chitinase [Monochamus alternatus] 170286892 AB428669.1 3470 0 Monochamus alternatus MaChiPm1 mRNA for chitinase, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W5U2 1858 7.5e-206 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF00704//PF01607//PF02532//PF03970 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//Herpesvirus UL37 tegument protein GO:0015979//GO:0006030//GO:0019068//GO:0005975 photosynthesis//chitin metabolic process//virion assembly//carbohydrate metabolic process GO:0004553//GO:0008061 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding GO:0005576//GO:0016020//GO:0009523//GO:0009539 extracellular region//membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.42665 BP_3 8.48 0.71 869 642921394 XP_008192849.1 424 3.8e-39 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270006281|gb|EFA02729.1| hypothetical protein TcasGA2_TC008454 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 268 1.9e-22 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF03193//PF00005//PF13304//PF01926//PF01637//PF02224 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Archaeal ATPase//Cytidylate kinase GO:0006139//GO:0006200//GO:0006206 nucleobase-containing compound metabolic process//obsolete ATP catabolic process//pyrimidine nucleobase metabolic process GO:0005524//GO:0003924//GO:0004127//GO:0016887//GO:0005525 ATP binding//GTPase activity//cytidylate kinase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.42666 BP_3 23.35 0.74 1811 646705747 KDR13306.1 534 1.4e-51 Aldehyde dehydrogenase family 3 member B1, partial [Zootermopsis nevadensis] -- -- -- -- -- K00129 E1.2.1.5 aldehyde dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00129 Q5XI42 458 3.8e-44 Aldehyde dehydrogenase family 3 member B1 OS=Rattus norvegicus GN=Aldh3b1 PE=2 SV=1 PF00389//PF00171 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0051287//GO:0016616 oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.42668 BP_3 12.00 0.33 2048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42669 BP_3 182.93 2.57 3724 242005288 XP_002423502.1 747 5.8e-76 beat protein, putative [Pediculus humanus corporis]>gi|212506606|gb|EEB10764.1| beat protein, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895//PF15339 Immunoglobulin domain//Acrosome formation-associated factor GO:0006897//GO:0007342//GO:0060478 endocytosis//fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis GO:0005515 protein binding GO:0016020//GO:0005886 membrane//plasma membrane -- -- Cluster-8309.4267 BP_3 8.37 1.33 595 642913139 XP_008201409.1 236 1.7e-17 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42670 BP_3 407.02 7.38 2949 260783431 XP_002586778.1 587 1.6e-57 hypothetical protein BRAFLDRAFT_102936 [Branchiostoma floridae]>gi|229271904|gb|EEN42789.1| hypothetical protein BRAFLDRAFT_102936 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q03938 398 5.6e-37 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF00096//PF13465//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.42671 BP_3 894.02 13.57 3467 91082257 XP_973105.1 1522 7.4e-166 PREDICTED: signal transducing adapter molecule 2 [Tribolium castaneum]>gi|270007457|gb|EFA03905.1| hypothetical protein TcasGA2_TC014037 [Tribolium castaneum] -- -- -- -- -- K04705 STAM signal transducing adaptor molecule http://www.genome.jp/dbget-bin/www_bget?ko:K04705 Q92783 870 1.2e-91 Signal transducing adapter molecule 1 OS=Homo sapiens GN=STAM PE=1 SV=3 PF00790//PF03127//PF14604//PF00018 VHS domain//GAT domain//Variant SH3 domain//SH3 domain GO:0006886 intracellular protein transport GO:0005515 protein binding GO:0005622 intracellular KOG2199 Signal transducing adaptor protein STAM/STAM2 Cluster-8309.42673 BP_3 421.69 49.90 699 270007898 EFA04346.1 784 5.6e-81 hypothetical protein TcasGA2_TC014642 [Tribolium castaneum] -- -- -- -- -- K16600 TTLL2 tubulin polyglutamylase TTLL2 http://www.genome.jp/dbget-bin/www_bget?ko:K16600 Q9BWV7 297 6.8e-26 Probable tubulin polyglutamylase TTLL2 OS=Homo sapiens GN=TTLL2 PE=5 SV=3 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- -- -- Cluster-8309.42674 BP_3 28.00 8.00 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42675 BP_3 871.74 9.87 4549 270007804 EFA04252.1 2632 1.9e-294 hypothetical protein TcasGA2_TC014542 [Tribolium castaneum] 831223259 XM_012804206.1 235 4.78365e-117 PREDICTED: Otolemur garnettii RAN binding protein 9 (RANBP9), mRNA -- -- -- -- Q96S59 1739 2.7e-192 Ran-binding protein 9 OS=Homo sapiens GN=RANBP9 PE=1 SV=1 PF00622//PF06005//PF07557//PF08513//PF04977//PF07989//PF17122 SPRY domain//Protein of unknown function (DUF904)//Shugoshin C terminus//LisH//Septum formation initiator//Centrosomin N-terminal motif 1//Zinc-finger GO:0045132//GO:0043093//GO:0000917//GO:0007049 meiotic chromosome segregation//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634//GO:0005815//GO:0000775//GO:0005737 nucleus//microtubule organizing center//chromosome, centromeric region//cytoplasm KOG1477 SPRY domain-containing proteins Cluster-8309.42676 BP_3 11.00 12.76 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42678 BP_3 226.78 2.17 5318 642921981 XP_008192968.1 2698 4.9e-302 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8NFZ3 776 1.5e-80 Neuroligin-4, Y-linked OS=Homo sapiens GN=NLGN4Y PE=2 SV=1 PF06330//PF07859 Trichodiene synthase (TRI5)//alpha/beta hydrolase fold GO:0016106//GO:0016114//GO:0008152 sesquiterpenoid biosynthetic process//terpenoid biosynthetic process//metabolic process GO:0045482//GO:0016787 trichodiene synthase activity//hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.42679 BP_3 367.89 3.54 5306 642921981 XP_008192968.1 2946 0.0e+00 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N0W4 891 6.8e-94 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF06330//PF07859 Trichodiene synthase (TRI5)//alpha/beta hydrolase fold GO:0008152//GO:0016114//GO:0016106 metabolic process//terpenoid biosynthetic process//sesquiterpenoid biosynthetic process GO:0016787//GO:0045482 hydrolase activity//trichodiene synthase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.42680 BP_3 123.34 1.79 3621 270007292 EFA03740.1 1285 2.3e-138 hypothetical protein TcasGA2_TC013849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006814//GO:0006090//GO:0071436//GO:0006525//GO:0006560 sodium ion transport//pyruvate metabolic process//sodium ion export//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.42682 BP_3 41.00 14.12 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42684 BP_3 259.58 2.87 4656 642915296 XP_008190559.1 391 1.4e-34 PREDICTED: signal recognition particle 9 kDa protein [Tribolium castaneum]>gi|270004979|gb|EFA01427.1| hypothetical protein TcasGA2_TC030568 [Tribolium castaneum] -- -- -- -- -- K03109 SRP9 signal recognition particle subunit SRP9 http://www.genome.jp/dbget-bin/www_bget?ko:K03109 Q9VSC1 231 2.0e-17 Signal recognition particle 9 kDa protein OS=Drosophila melanogaster GN=Srp9 PE=3 SV=1 -- -- GO:0006614//GO:0045900 SRP-dependent cotranslational protein targeting to membrane//negative regulation of translational elongation GO:0008312 7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3465 Signal recognition particle, subunit Srp9 Cluster-8309.42685 BP_3 91.00 4.34 1302 641649259 XP_008185329.1 145 1.3e-06 PREDICTED: uncharacterized protein LOC100573760 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667//PF05933 Phage shock protein B//Fungal ATP synthase protein 8 (A6L) GO:0006355//GO:0009271//GO:0015986//GO:0015992 regulation of transcription, DNA-templated//phage shock//ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.42686 BP_3 293.36 2.96 5069 642922756 XP_008193311.1 2454 9.1e-274 PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|642922758|ref|XP_008193312.1| PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X1 [Tribolium castaneum] 751220523 XM_011165095.1 223 2.49968e-110 PREDICTED: Solenopsis invicta RNA pseudouridylate synthase domain-containing protein 2-like (LOC105198399), transcript variant X3, mRNA -- -- -- -- Q8IZ73 1040 3.4e-111 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF00951//PF13895//PF00849 Arterivirus GL envelope glycoprotein//Immunoglobulin domain//RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0005515//GO:0003723//GO:0009982 protein binding//RNA binding//pseudouridine synthase activity GO:0019031 viral envelope KOG1919 RNA pseudouridylate synthases Cluster-8309.42688 BP_3 134.00 12.18 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42689 BP_3 365.80 2.58 7131 91077046 XP_968112.1 1016 7.1e-107 PREDICTED: ras-related C3 botulinum toxin substrate 1 [Tribolium castaneum]>gi|270002813|gb|EEZ99260.1| Mig-2-like protein [Tribolium castaneum] 746848885 XM_011056563.1 186 1.30316e-89 PREDICTED: Acromyrmex echinatior ras-related C3 botulinum toxin substrate 1 (LOC105146367), mRNA K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 Q6RUV5 770 9.9e-80 Ras-related C3 botulinum toxin substrate 1 OS=Rattus norvegicus GN=Rac1 PE=1 SV=1 PF08477//PF05656//PF01501//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function (DUF805)//Glycosyl transferase family 8//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0016757//GO:0005525 transferase activity, transferring glycosyl groups//GTP binding GO:0005622//GO:0016020//GO:0016021 intracellular//membrane//integral component of membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.42690 BP_3 519.57 3.93 6665 512885476 XP_004921601.1 4075 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX8 [Bombyx mori] 817212638 XM_012427088.1 642 0 PREDICTED: Orussus abietinus ATP-dependent RNA helicase DHX8 (LOC105700863), mRNA K12818 DHX8, PRP22 ATP-dependent RNA helicase DHX8/PRP22 http://www.genome.jp/dbget-bin/www_bget?ko:K12818 A2A4P0 3623 0.0e+00 ATP-dependent RNA helicase DHX8 OS=Mus musculus GN=Dhx8 PE=2 SV=1 PF07652//PF00437//PF00270//PF14532//PF00005//PF00575//PF04408 Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase//Sigma-54 interaction domain//ABC transporter//S1 RNA binding domain//Helicase associated domain (HA2) GO:0006355//GO:0019079//GO:0006810 regulation of transcription, DNA-templated//viral genome replication//transport GO:0003676//GO:0016887//GO:0005524//GO:0004386//GO:0008134//GO:0008026 nucleic acid binding//ATPase activity//ATP binding//helicase activity//transcription factor binding//ATP-dependent helicase activity GO:0005667 transcription factor complex KOG0922 DEAH-box RNA helicase Cluster-8309.42693 BP_3 1.00 1.84 300 260810234 XP_002599908.1 186 5.2e-12 hypothetical protein BRAFLDRAFT_58115 [Branchiostoma floridae]>gi|229285192|gb|EEN55920.1| hypothetical protein BRAFLDRAFT_58115 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P52746 143 2.1e-08 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF00301//PF07649//PF04988//PF13465//PF00096//PF06397//PF02150 Rubredoxin//C1-like domain//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain//RNA polymerases M/15 Kd subunit GO:0055114//GO:0006206//GO:0006144//GO:0006351 oxidation-reduction process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0047134//GO:0046872//GO:0005506//GO:0003899//GO:0003677 protein-disulfide reductase activity//metal ion binding//iron ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.42694 BP_3 1.00 2.95 281 642926860 XP_971810.2 151 5.6e-08 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF02150 Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//metal ion binding GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.42695 BP_3 11.00 4.01 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42696 BP_3 58.53 8.67 617 514683686 XP_004989424.1 181 4.1e-11 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- Q86Y25 143 4.3e-08 Zinc finger protein 354C OS=Homo sapiens GN=ZNF354C PE=2 SV=1 PF01146//PF00096//PF13465 Caveolin//Zinc finger, C2H2 type//Zinc-finger double domain GO:0070836 caveola assembly GO:0046872 metal ion binding -- -- -- -- Cluster-8309.42697 BP_3 7.22 0.51 978 514683686 XP_004989424.1 330 3.4e-28 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- Q13127 232 3.3e-18 RE1-silencing transcription factor OS=Homo sapiens GN=REST PE=1 SV=3 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.42698 BP_3 9.27 0.83 832 260823164 XP_002604053.1 192 2.9e-12 hypothetical protein BRAFLDRAFT_119781 [Branchiostoma floridae]>gi|229289378|gb|EEN60064.1| hypothetical protein BRAFLDRAFT_119781 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q642B9 136 3.8e-07 Zinc finger protein 18 OS=Rattus norvegicus GN=Znf18 PE=2 SV=1 PF02918//PF15036//PF00096//PF13465 Pertussis toxin, subunit 2 and 3, C-terminal domain//Interleukin 34//Zinc finger, C2H2 type//Zinc-finger double domain GO:0008284//GO:0001934//GO:0007165//GO:0009405//GO:0040007//GO:0008283 positive regulation of cell proliferation//positive regulation of protein phosphorylation//signal transduction//pathogenesis//growth//cell proliferation GO:0005157//GO:0046872 macrophage colony-stimulating factor receptor binding//metal ion binding GO:0005576//GO:0005615 extracellular region//extracellular space -- -- Cluster-8309.42700 BP_3 9.47 1.63 571 260815961 XP_002602741.1 223 5.1e-16 hypothetical protein BRAFLDRAFT_233840 [Branchiostoma floridae]>gi|229288052|gb|EEN58753.1| hypothetical protein BRAFLDRAFT_233840, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q2EI21 148 1.0e-08 RE1-silencing transcription factor A OS=Xenopus laevis GN=rest-a PE=2 SV=1 PF00096//PF13465//PF02150//PF00301//PF07649 Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit//Rubredoxin//C1-like domain GO:0006206//GO:0055114//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process GO:0047134//GO:0046872//GO:0005506//GO:0003899//GO:0003677 protein-disulfide reductase activity//metal ion binding//iron ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.42701 BP_3 14.15 1.51 743 514683686 XP_004989424.1 263 1.5e-20 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- O54963 200 1.3e-14 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF00096//PF13465//PF04988 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.42702 BP_3 1467.66 10.23 7205 546684210 ERL93915.1 1855 3.7e-204 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 119 2.31527e-52 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1311 1.8e-142 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF01105//PF00614//PF00412 emp24/gp25L/p24 family/GOLD//Phospholipase D Active site motif//LIM domain GO:0006810 transport GO:0003824//GO:0008270 catalytic activity//zinc ion binding GO:0016021 integral component of membrane KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.42703 BP_3 275.72 6.16 2448 270009982 EFA06430.1 1027 1.3e-108 hypothetical protein TcasGA2_TC009310 [Tribolium castaneum] -- -- -- -- -- K14689 SLC30A2, ZNT2 solute carrier family 30 (zinc transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14689 Q2HJ10 661 1.5e-67 Zinc transporter 2 OS=Mus musculus GN=Slc30a2 PE=2 SV=1 PF01545//PF12822 Cation efflux family//Protein of unknown function (DUF3816) GO:0055085//GO:0006812//GO:0006810 transmembrane transport//cation transport//transport GO:0008324//GO:0005215 cation transmembrane transporter activity//transporter activity GO:0016021 integral component of membrane KOG1482 Zn2+ transporter Cluster-8309.42705 BP_3 88.94 5.68 1047 642930472 XP_008196416.1 652 1.7e-65 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 561 2.5e-56 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.42706 BP_3 1092.03 6.63 8231 642929799 XP_008195982.1 2636 1.2e-294 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 2-like [Tribolium castaneum] 118150627 NM_001077805.1 77 5.89346e-29 Danio rerio oxysterol binding protein-like 9 (osbpl9), mRNA >gnl|BL_ORD_ID|3545007 Danio rerio oxysterol binding protein-like 9, mRNA (cDNA clone MGC:154069 IMAGE:8338829), complete cds -- -- -- -- Q0IJ05 1433 1.5e-156 Oxysterol-binding protein-related protein 9 OS=Xenopus tropicalis GN=osbpl9 PE=2 SV=1 PF01421//PF05093//PF01562//PF10462//PF00413 Reprolysin (M12B) family zinc metalloprotease//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//Reprolysin family propeptide//Peptidase M66//Matrixin GO:0006508//GO:0016226 proteolysis//iron-sulfur cluster assembly GO:0004222//GO:0008270//GO:0051536 metalloendopeptidase activity//zinc ion binding//iron-sulfur cluster binding GO:0005737//GO:0031012 cytoplasm//extracellular matrix KOG2210 Oxysterol-binding protein Cluster-8309.42708 BP_3 2113.29 36.21 3105 642925798 XP_008190328.1 1995 9.4e-221 PREDICTED: protein PAT1 homolog 1 [Tribolium castaneum] 642925797 XM_008192106.1 59 2.23951e-19 PREDICTED: Tribolium castaneum protein PAT1 homolog 1 (LOC100142489), mRNA -- -- -- -- B5DF93 310 9.4e-27 Protein PAT1 homolog 1 OS=Rattus norvegicus GN=Patl1 PE=2 SV=1 PF12558 ATP-binding cassette cobalt transporter -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- -- -- Cluster-8309.42709 BP_3 714.00 29.38 1463 642919707 XP_008192031.1 782 2.0e-80 PREDICTED: cleavage and polyadenylation specificity factor subunit CG7185 [Tribolium castaneum] -- -- -- -- -- K14398 CPSF6_7 cleavage and polyadenylation specificity factor subunit 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14398 Q9VSH4 418 1.3e-39 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4849 mRNA cleavage factor I subunit/CPSF subunit Cluster-8309.4271 BP_3 14.08 0.51 1629 91087945 XP_972135.1 1136 2.0e-121 PREDICTED: CUE domain-containing protein 2 [Tribolium castaneum]>gi|270011934|gb|EFA08382.1| hypothetical protein TcasGA2_TC006025 [Tribolium castaneum] 642930958 XM_967042.2 295 7.48347e-151 PREDICTED: Tribolium castaneum CUE domain-containing protein 2 (LOC660839), mRNA -- -- -- -- Q6TLH3 407 2.8e-38 CUE domain-containing protein 2 OS=Danio rerio GN=cuedc2 PE=2 SV=1 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42711 BP_3 2005.97 32.29 3286 646724140 KDR24501.1 2122 1.9e-235 BTB/POZ domain-containing protein 3 [Zootermopsis nevadensis] 560970175 XM_006207391.1 80 5.02578e-31 PREDICTED: Vicugna pacos BTB (POZ) domain containing 3 (BTBD3), transcript variant X2, mRNA K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 1671 1.5e-184 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.42712 BP_3 133.41 0.60 11042 642934936 XP_008195867.1 3146 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 205 5.54187e-100 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 548 8.4e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05197//PF05225 TRIC channel//helix-turn-helix, Psq domain GO:0006812//GO:0015672 cation transport//monovalent inorganic cation transport GO:0005261//GO:0003677 cation channel activity//DNA binding GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.42713 BP_3 747.06 3.34 11071 642934936 XP_008195867.1 3146 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 205 5.55647e-100 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 548 8.5e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05197//PF05225 TRIC channel//helix-turn-helix, Psq domain GO:0006812//GO:0015672 cation transport//monovalent inorganic cation transport GO:0005261//GO:0003677 cation channel activity//DNA binding GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.42714 BP_3 103.13 0.47 10779 642934938 XP_008195872.1 3008 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X2 [Tribolium castaneum] 462277734 APGK01058896.1 184 2.55262e-88 Dendroctonus ponderosae Seq01058906, whole genome shotgun sequence -- -- -- -- Q95YM8 548 8.2e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05225//PF05197 helix-turn-helix, Psq domain//TRIC channel GO:0015672//GO:0006812 monovalent inorganic cation transport//cation transport GO:0003677//GO:0005261 DNA binding//cation channel activity GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.42716 BP_3 254.82 2.85 4597 350414142 XP_003490218.1 2832 0.0e+00 PREDICTED: protein O-GlcNAcase isoform X3 [Bombus impatiens] 830022072 XM_012723671.1 44 7.25554e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 1092 2.9e-117 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 PF05418//PF00736 Apovitellenin I (Apo-VLDL-II)//EF-1 guanine nucleotide exchange domain GO:0006414//GO:0006629//GO:0006448 translational elongation//lipid metabolic process//regulation of translational elongation GO:0003746//GO:0004857 translation elongation factor activity//enzyme inhibitor activity GO:0005853//GO:0005840//GO:0042627 eukaryotic translation elongation factor 1 complex//ribosome//chylomicron KOG3698 Hyaluronoglucosaminidase Cluster-8309.42717 BP_3 1236.00 10.73 5844 642910543 XP_008200257.1 3897 0.0e+00 PREDICTED: zinc finger MYM-type protein 3 isoform X1 [Tribolium castaneum] 462332881 APGK01039173.1 211 1.3516e-103 Dendroctonus ponderosae Seq01039183, whole genome shotgun sequence -- -- -- -- Q9JLM4 734 1.2e-75 Zinc finger MYM-type protein 3 OS=Mus musculus GN=Zmym3 PE=2 SV=1 PF06467//PF08140 MYM-type Zinc finger with FCS sequence motif//Crustacean cuticle protein repeat -- -- GO:0008270//GO:0042302 zinc ion binding//structural constituent of cuticle -- -- -- -- Cluster-8309.42718 BP_3 801.57 19.31 2293 646682520 KDR02319.1 1568 2.3e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.6622e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.1e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF00069//PF07714//PF00937 Protein kinase domain//Protein tyrosine kinase//Coronavirus nucleocapsid protein GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.42719 BP_3 116.49 1.25 4790 642910776 XP_008193405.1 2380 3.3e-265 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 3.37229e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1134 4.1e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.4272 BP_3 9.00 0.43 1297 642915450 XP_008190622.1 1508 1.2e-164 PREDICTED: E3 ubiquitin-protein ligase MYCBP2 [Tribolium castaneum] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 O75592 788 1.5e-82 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3 PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.42720 BP_3 2303.60 13.98 8233 642913878 XP_975183.2 4525 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X1 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.60458e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q96C24 760 1.6e-78 Synaptotagmin-like protein 4 OS=Homo sapiens GN=SYTL4 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.42722 BP_3 640.00 10.12 3339 478260891 ENN80525.1 598 9.9e-59 hypothetical protein YQE_03054, partial [Dendroctonus ponderosae]>gi|478265306|gb|ENN82461.1| hypothetical protein YQE_01164, partial [Dendroctonus ponderosae]>gi|478265308|gb|ENN82462.1| hypothetical protein YQE_01163, partial [Dendroctonus ponderosae]>gi|546683001|gb|ERL92873.1| hypothetical protein D910_10179 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00198//PF03145 2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Seven in absentia protein family GO:0007275//GO:0008152//GO:0006511 multicellular organismal development//metabolic process//ubiquitin-dependent protein catabolic process GO:0016746 transferase activity, transferring acyl groups GO:0005634 nucleus -- -- Cluster-8309.42724 BP_3 166.13 5.51 1745 642919181 XP_008191771.1 737 3.9e-75 PREDICTED: uncharacterized protein LOC103312580 isoform X1 [Tribolium castaneum]>gi|270005582|gb|EFA02030.1| hypothetical protein TcasGA2_TC007655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42725 BP_3 6379.96 71.74 4578 197276682 NP_001127850.1 1395 5.2e-151 smoothened precursor [Tribolium castaneum]>gi|270012713|gb|EFA09161.1| smoothened [Tribolium castaneum] 645012677 XM_001604820.3 303 7.6129e-155 PREDICTED: Nasonia vitripennis uncharacterized LOC100119467 (LOC100119467), mRNA -- -- -- -- P91682 670 2.5e-68 Protein smoothened OS=Drosophila melanogaster GN=smo PE=1 SV=1 PF01534 Frizzled/Smoothened family membrane region GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.42727 BP_3 520.62 4.58 5767 642917541 XP_008191247.1 5924 0.0e+00 PREDICTED: protein TANC2 isoform X3 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.16276e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.0e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF13606//PF00097//PF07728//PF00004//PF01637//PF00023//PF02376//PF13414//PF13639 Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Ankyrin repeat//CUT domain//TPR repeat//Ring finger domain -- -- GO:0016887//GO:0003677//GO:0005524//GO:0008270//GO:0046872//GO:0005515 ATPase activity//DNA binding//ATP binding//zinc ion binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.42731 BP_3 923.38 17.14 2889 642919618 XP_008191942.1 2169 5.8e-241 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] 642919617 XM_008193720.1 423 0 PREDICTED: Tribolium castaneum protein kinase C and casein kinase substrate in neurons protein 1 (LOC103312632), mRNA -- -- -- -- Q4V920 1060 9.4e-114 Protein kinase C and casein kinase substrate in neurons protein 1 OS=Danio rerio GN=pacsin1b PE=1 SV=1 PF03947//PF02173//PF08397//PF14604//PF00018//PF03938 Ribosomal Proteins L2, C-terminal domain//pKID domain//IRSp53/MIM homology domain//Variant SH3 domain//SH3 domain//Outer membrane protein (OmpH-like) GO:0042254//GO:0007009//GO:0006355//GO:0006412 ribosome biogenesis//plasma membrane organization//regulation of transcription, DNA-templated//translation GO:0003735//GO:0051082//GO:0005515 structural constituent of ribosome//unfolded protein binding//protein binding GO:0005840 ribosome KOG2856 Adaptor protein PACSIN Cluster-8309.42732 BP_3 41.17 0.85 2639 642919618 XP_008191942.1 572 8.1e-56 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] 642919617 XM_008193720.1 76 6.74039e-29 PREDICTED: Tribolium castaneum protein kinase C and casein kinase substrate in neurons protein 1 (LOC103312632), mRNA -- -- -- -- Q9DDA9 294 5.7e-25 Protein kinase C and casein kinase substrate in neurons protein 2 OS=Xenopus laevis GN=pacsin2 PE=2 SV=1 PF03947//PF01786//PF15460 Ribosomal Proteins L2, C-terminal domain//Alternative oxidase//Something about silencing, SAS, complex subunit 4 GO:0006412//GO:0016573//GO:0055114//GO:0042254//GO:0006118 translation//histone acetylation//oxidation-reduction process//ribosome biogenesis//obsolete electron transport GO:0009916//GO:0003735 alternative oxidase activity//structural constituent of ribosome GO:0005840 ribosome KOG2856 Adaptor protein PACSIN Cluster-8309.42734 BP_3 41.46 0.77 2892 189236914 XP_969111.2 1678 5.0e-184 PREDICTED: alpha-(1,6)-fucosyltransferase [Tribolium castaneum]>gi|270006336|gb|EFA02784.1| hypothetical protein TcasGA2_TC008521 [Tribolium castaneum] 170044484 XM_001849824.1 187 1.45917e-90 Culex quinquefasciatus alpha-(1,6)-fucosyltransferase, mRNA K00717 FUT8 glycoprotein 6-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00717 Q9VYV5 1329 6.0e-145 Alpha-(1,6)-fucosyltransferase OS=Drosophila melanogaster GN=FucT6 PE=1 SV=1 PF14604 Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3705 Glycoprotein 6-alpha-L-fucosyltransferase Cluster-8309.42735 BP_3 28.82 0.48 3203 478257125 ENN77288.1 488 5.4e-46 hypothetical protein YQE_06114, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0P5B9 244 4.4e-19 Ankyrin repeat domain-containing protein 39 OS=Bos taurus GN=ANKRD39 PE=2 SV=1 PF13606//PF06399//PF00023 Ankyrin repeat//GTP cyclohydrolase I feedback regulatory protein (GFRP)//Ankyrin repeat GO:0009890 negative regulation of biosynthetic process GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.42736 BP_3 127.90 10.17 898 642913015 XP_008201353.1 572 2.7e-56 PREDICTED: spectrin alpha chain [Tribolium castaneum]>gi|270002786|gb|EEZ99233.1| alpha spectrin [Tribolium castaneum] 768429654 XM_011557714.1 143 1.27233e-66 PREDICTED: Plutella xylostella spectrin alpha chain-like (LOC105387044), mRNA K06114 SPTA spectrin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06114 P13395 536 1.7e-53 Spectrin alpha chain OS=Drosophila melanogaster GN=alpha-Spec PE=1 SV=2 PF13202//PF13499//PF13405//PF10591//PF13833//PF00036 EF hand//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.42739 BP_3 1789.03 10.17 8770 642920269 XP_008192276.1 3095 0.0e+00 PREDICTED: anoctamin-1-like isoform X2 [Tribolium castaneum] 780682419 XM_011699543.1 39 8.35836e-08 PREDICTED: Wasmannia auropunctata anoctamin-1 (LOC105455869), transcript variant X4, mRNA K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q8BHY3 1545 1.6e-169 Anoctamin-1 OS=Mus musculus GN=Ano1 PE=1 SV=2 PF01091//PF13939//PF16178 PTN/MK heparin-binding protein family, C-terminal domain//Toxin TisB, type I toxin-antitoxin system//Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0008283//GO:0007165//GO:0040007//GO:0006820//GO:0022611//GO:0009432 cell proliferation//signal transduction//growth//anion transport//dormancy process//SOS response GO:0046983//GO:0008083//GO:0005253 protein dimerization activity//growth factor activity//anion channel activity GO:0005887 integral component of plasma membrane KOG2514 Uncharacterized conserved protein Cluster-8309.42740 BP_3 198.91 2.74 3795 642937773 XP_008198939.1 3931 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X1 [Tribolium castaneum]>gi|270000767|gb|EEZ97214.1| hypothetical protein TcasGA2_TC011007 [Tribolium castaneum] 665815760 XM_008558331.1 166 9.06265e-79 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 2218 6.5e-248 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF05309//PF00122 TraE protein//E1-E2 ATPase GO:0006812//GO:0000746//GO:0015917//GO:0015914 cation transport//conjugation//aminophospholipid transport//phospholipid transport GO:0000166//GO:0046872//GO:0000287//GO:0005524//GO:0015662//GO:0004012 nucleotide binding//metal ion binding//magnesium ion binding//ATP binding//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//phospholipid-translocating ATPase activity GO:0016021 integral component of membrane KOG0206 P-type ATPase Cluster-8309.42741 BP_3 366.58 2.81 6579 642937777 XP_008198941.1 5493 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X3 [Tribolium castaneum] 665815760 XM_008558331.1 166 1.57673e-78 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 3294 0.0e+00 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.42742 BP_3 19.81 0.33 3203 91091818 XP_966528.1 1772 7.0e-195 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1300 1.5e-141 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF00060//PF10613//PF06495//PF03509 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//Fruit fly transformer protein//Gap junction alpha-8 protein (Cx50) GO:0007154//GO:0046660//GO:0006811//GO:0007165//GO:0006397//GO:0007268//GO:0006810 cell communication//female sex differentiation//ion transport//signal transduction//mRNA processing//synaptic transmission//transport GO:0005215//GO:0004970//GO:0005234 transporter activity//ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020//GO:0005922//GO:0005634 membrane//connexon complex//nucleus -- -- Cluster-8309.42743 BP_3 382.43 2.23 8554 642923695 XP_008193847.1 6170 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 1849 9.0e-205 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF03361//PF15723//PF00122 Herpes virus intermediate/early protein 2/3//Motility quorum-sensing regulator, toxin of MqsA//E1-E2 ATPase GO:0009372//GO:0017148//GO:0042710//GO:0006355 quorum sensing//negative regulation of translation//biofilm formation//regulation of transcription, DNA-templated GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.42744 BP_3 254.82 2.13 6065 189240413 XP_969795.2 2244 2.4e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.26177e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.3e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00498//PF00250 FHA domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0005515//GO:0003700 sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42745 BP_3 11.65 0.39 1738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42746 BP_3 1440.76 6.78 10527 270011577 EFA08025.1 572 3.2e-55 hypothetical protein TcasGA2_TC005614 [Tribolium castaneum] -- -- -- -- -- K18462 FAM21 WASH complex subunit FAM21 http://www.genome.jp/dbget-bin/www_bget?ko:K18462 Q641Q2 188 4.5e-12 WASH complex subunit FAM21A OS=Homo sapiens GN=FAM21A PE=2 SV=3 PF06003//PF04889//PF09726//PF02724//PF05132 Survival motor neuron protein (SMN)//Cwf15/Cwc15 cell cycle control protein//Transmembrane protein//CDC45-like protein//RNA polymerase III RPC4 GO:0006351//GO:0006383//GO:0006397//GO:0006144//GO:0006206//GO:0006270//GO:0000398 transcription, DNA-templated//transcription from RNA polymerase III promoter//mRNA processing//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//DNA replication initiation//mRNA splicing, via spliceosome GO:0003723//GO:0003677//GO:0003899 RNA binding//DNA binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005681//GO:0016021//GO:0005666//GO:0005737//GO:0005730 nucleus//spliceosomal complex//integral component of membrane//DNA-directed RNA polymerase III complex//cytoplasm//nucleolus -- -- Cluster-8309.42747 BP_3 151.37 6.64 1391 642928939 XP_008195625.1 1132 4.9e-121 PREDICTED: UTP--glucose-1-phosphate uridylyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00963 UGP2, galU, galF UTP--glucose-1-phosphate uridylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00963 Q07130 835 5.6e-88 UTP--glucose-1-phosphate uridylyltransferase OS=Bos taurus GN=UGP2 PE=1 SV=2 PF01704 UTP--glucose-1-phosphate uridylyltransferase GO:0008152 metabolic process GO:0070569 uridylyltransferase activity -- -- KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.42748 BP_3 5.33 0.50 810 91087535 XP_970133.1 481 8.8e-46 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] -- -- -- -- -- K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 319 2.2e-28 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.42749 BP_3 434.71 5.34 4217 642913457 XP_008201020.1 4121 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2238 3.5e-250 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00784//PF00023//PF13606 MyTH4 domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.42750 BP_3 153.44 2.07 3858 642911681 XP_008200699.1 3110 0.0e+00 PREDICTED: stAR-related lipid transfer protein 13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q923Q2 1160 3.2e-125 StAR-related lipid transfer protein 13 OS=Mus musculus GN=Stard13 PE=1 SV=5 PF07647//PF01852//PF00620//PF03121 SAM domain (Sterile alpha motif)//START domain//RhoGAP domain//Herpesviridae UL52/UL70 DNA primase GO:0006351//GO:0007165//GO:0006269//GO:0006260 transcription, DNA-templated//signal transduction//DNA replication, synthesis of RNA primer//DNA replication GO:0005515//GO:0008289//GO:0003896 protein binding//lipid binding//DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 Cluster-8309.42751 BP_3 40.00 0.63 3328 546682942 ERL92821.1 301 2.7e-24 hypothetical protein D910_10129 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42752 BP_3 978.06 15.07 3420 91081375 XP_972116.1 4329 0.0e+00 PREDICTED: chromatin-remodeling complex ATPase chain Iswi [Tribolium castaneum]>gi|270005181|gb|EFA01629.1| hypothetical protein TcasGA2_TC007199 [Tribolium castaneum] 815799995 XR_001100589.1 645 0 PREDICTED: Linepithema humile chromatin-remodeling complex ATPase chain Iswi (LOC105671246), transcript variant X2, misc_RNA K11654 SMARCA5, SNF2H, ISWI SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11654 Q24368 3762 0.0e+00 Chromatin-remodeling complex ATPase chain Iswi OS=Drosophila melanogaster GN=Iswi PE=1 SV=1 PF09111//PF06422//PF05416//PF04851//PF09110//PF00176//PF13892//PF00270 SLIDE//CDR ABC transporter//Southampton virus-type processing peptidase//Type III restriction enzyme, res subunit//HAND//SNF2 family N-terminal domain//DNA-binding domain//DEAD/DEAH box helicase GO:0006338//GO:0006810//GO:0043044//GO:0006508 chromatin remodeling//transport//ATP-dependent chromatin remodeling//proteolysis GO:0005524//GO:0016787//GO:0016818//GO:0042626//GO:0031491//GO:0004386//GO:0003677//GO:0004197//GO:0003676 ATP binding//hydrolase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATPase activity, coupled to transmembrane movement of substances//nucleosome binding//helicase activity//DNA binding//cysteine-type endopeptidase activity//nucleic acid binding GO:0016585//GO:0016021//GO:0005634//GO:0000785 obsolete chromatin remodeling complex//integral component of membrane//nucleus//chromatin KOG0385 Chromatin remodeling complex WSTF-ISWI, small subunit Cluster-8309.42758 BP_3 247.06 4.27 3080 642929390 XP_008195816.1 919 5.5e-96 PREDICTED: cysteine dioxygenase type 1 [Tribolium castaneum]>gi|270010522|gb|EFA06970.1| hypothetical protein TcasGA2_TC009929 [Tribolium castaneum] -- -- -- -- -- K00456 CDO1 cysteine dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00456 Q6NWZ9 594 1.1e-59 Cysteine dioxygenase type 1 OS=Danio rerio GN=cdo1 PE=2 SV=1 PF07847//PF05995 Protein of unknown function (DUF1637)//Cysteine dioxygenase type I GO:0019530//GO:0006534//GO:0055114//GO:0046439 taurine metabolic process//cysteine metabolic process//oxidation-reduction process//L-cysteine metabolic process GO:0005506//GO:0016702//GO:0017172 iron ion binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//cysteine dioxygenase activity -- -- KOG4064 Cysteine dioxygenase CDO1 Cluster-8309.42759 BP_3 240.28 5.60 2361 642932773 XP_008196977.1 3190 0.0e+00 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 759067243 XM_011344784.1 294 3.92755e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 4.8e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233//PF01590//PF13492//PF13185//PF07533 3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain//GAF domain//BRK domain GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114//GO:0016817//GO:0005515 3',5'-cyclic-nucleotide phosphodiesterase activity//hydrolase activity, acting on acid anhydrides//protein binding -- -- -- -- Cluster-8309.42760 BP_3 305.94 8.89 1950 91084515 XP_967225.1 680 1.8e-68 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.42762 BP_3 782.09 7.17 5550 642936966 XP_008198632.1 3226 0.0e+00 PREDICTED: rab GTPase-activating protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RAN1 1670 3.3e-184 Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1 PF13465//PF05443//PF00640//PF02892//PF13912//PF16622//PF00096//PF14719//PF07776 Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//Phosphotyrosine interaction domain (PTB/PID)//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Phosphotyrosine interaction domain (PTB/PID)//Zinc-finger associated domain (zf-AD) GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046872//GO:0008270//GO:0003677 protein binding//metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.42764 BP_3 68691.78 558.68 6218 642932323 XP_008197064.1 2163 6.2e-240 PREDICTED: mucin-17-like [Tribolium castaneum]>gi|270011608|gb|EFA08056.1| hypothetical protein TcasGA2_TC005652 [Tribolium castaneum] 462278420 APGK01058650.1 63 2.69586e-21 Dendroctonus ponderosae Seq01058660, whole genome shotgun sequence -- -- -- -- Q13231 222 3.0e-16 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF01607 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553//GO:0043169 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding GO:0005576 extracellular region -- -- Cluster-8309.42767 BP_3 69.62 0.48 7250 642931401 XP_008196564.1 7208 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 [Tribolium castaneum] 170051315 XM_001861674.1 59 5.26181e-19 Culex quinquefasciatus BIG3, mRNA K17572 ARFGEF3, KEPI brefeldin A-inhibited guanine nucleotide-exchange protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17572 Q3UGY8 1263 6.8e-137 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Mus musculus GN=Arfgef3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0929 Guanine nucleotide exchange factor Cluster-8309.42769 BP_3 75.55 1.41 2868 91082351 XP_967256.1 712 5.1e-72 PREDICTED: probable uridine nucleosidase 1 [Tribolium castaneum]>gi|270007493|gb|EFA03941.1| hypothetical protein TcasGA2_TC014082 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q10314 203 2.2e-14 Uncharacterized protein C17G8.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC17G8.02 PE=3 SV=1 PF01105//PF06156//PF02212//PF01496 emp24/gp25L/p24 family/GOLD//Protein of unknown function (DUF972)//Dynamin GTPase effector domain//V-type ATPase 116kDa subunit family GO:0006260//GO:0015992//GO:0006810//GO:0015991 DNA replication//proton transport//transport//ATP hydrolysis coupled proton transport GO:0005525//GO:0015078//GO:0003924 GTP binding//hydrogen ion transmembrane transporter activity//GTPase activity GO:0033179//GO:0016021 proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG2938 Predicted inosine-uridine preferring nucleoside hydrolase Cluster-8309.42772 BP_3 59.78 1.01 3144 270007530 EFA03978.1 1703 6.9e-187 hypothetical protein TcasGA2_TC014127 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N695 750 9.1e-78 Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=2 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.42774 BP_3 48.51 0.51 4854 642929984 XP_008196053.1 2645 6.2e-296 PREDICTED: atrial natriuretic peptide receptor 1 [Tribolium castaneum] 642929983 XM_008197831.1 317 1.33233e-162 PREDICTED: Tribolium castaneum atrial natriuretic peptide receptor 1 (LOC664507), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18910 1611 2.0e-177 Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus GN=Npr1 PE=1 SV=1 PF07714//PF00211//PF00069//PF06330//PF07701 Protein tyrosine kinase//Adenylate and Guanylate cyclase catalytic domain//Protein kinase domain//Trichodiene synthase (TRI5)//Heme NO binding associated GO:0006182//GO:0046039//GO:0016114//GO:0006468//GO:0006144//GO:0016106//GO:0035556//GO:0009190 cGMP biosynthetic process//GTP metabolic process//terpenoid biosynthetic process//protein phosphorylation//purine nucleobase metabolic process//sesquiterpenoid biosynthetic process//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0005524//GO:0004383//GO:0045482//GO:0004672//GO:0016849 ATP binding//guanylate cyclase activity//trichodiene synthase activity//protein kinase activity//phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.42775 BP_3 365.23 4.27 4418 270001801 EEZ98248.1 1216 2.8e-130 hypothetical protein TcasGA2_TC000687 [Tribolium castaneum] 817087970 XM_012411364.1 53 6.92165e-16 PREDICTED: Athalia rosae Y+L amino acid transporter 2 (LOC105692280), transcript variant X4, mRNA K13872 SLC7A6 solute carrier family 7 (L-type amino acid transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13872 Q8BGK6 703 3.6e-72 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF01990//PF13520//PF00324//PF01424 ATP synthase (F/14-kDa) subunit//Amino acid permease//Amino acid permease//R3H domain GO:0003333//GO:0006865//GO:0055085//GO:0034220//GO:0006810 amino acid transmembrane transport//amino acid transport//transmembrane transport//ion transmembrane transport//transport GO:0003676//GO:0015171 nucleic acid binding//amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.42776 BP_3 91.00 11.01 690 642915065 XP_008190395.1 375 1.5e-33 PREDICTED: protein groucho isoform X1 [Tribolium castaneum]>gi|270002870|gb|EEZ99317.1| groucho-like protein [Tribolium castaneum] 642915072 XM_008192177.1 141 1.24963e-65 PREDICTED: Tribolium castaneum protein groucho (LOC656496), transcript variant X5, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 348 8.2e-32 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF04136//PF03920//PF02183 Sec34-like family//Groucho/TLE N-terminal Q-rich domain//Homeobox associated leucine zipper GO:0006886//GO:0006355 intracellular protein transport//regulation of transcription, DNA-templated GO:0005515//GO:0043565//GO:0003700 protein binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0016020//GO:0005801 nucleus//transcription factor complex//membrane//cis-Golgi network -- -- Cluster-8309.42777 BP_3 311.50 6.95 2452 642915067 XP_008190396.1 2531 5.2e-283 PREDICTED: protein groucho isoform X2 [Tribolium castaneum] 602715430 XM_007467859.1 376 0 PREDICTED: Lipotes vexillifer transducin-like enhancer of split 3 (TLE3), transcript variant X12, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 2053 5.7e-229 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF03920//PF00400 Groucho/TLE N-terminal Q-rich domain//WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.42780 BP_3 151.88 0.65 11576 642933099 XP_973043.3 3459 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.4e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF14572//PF00076//PF08587//PF00156 Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ubiquitin associated domain (UBA)//Phosphoribosyl transferase domain GO:0006098//GO:0009165//GO:0016310//GO:0006144//GO:0009069//GO:0009116 pentose-phosphate shunt//nucleotide biosynthetic process//phosphorylation//purine nucleobase metabolic process//serine family amino acid metabolic process//nucleoside metabolic process GO:0003676//GO:0004674//GO:0000287//GO:0004749 nucleic acid binding//protein serine/threonine kinase activity//magnesium ion binding//ribose phosphate diphosphokinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.42781 BP_3 1701.96 52.18 1864 91082269 XP_973494.1 933 7.9e-98 PREDICTED: eukaryotic translation initiation factor 4E-1A [Tribolium castaneum]>gi|270008177|gb|EFA04625.1| eukaryotic initiation factor 4E [Tribolium castaneum] -- -- -- -- -- K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 Q9DFS6 636 8.9e-65 Eukaryotic translation initiation factor 4E-1A OS=Danio rerio GN=eif4e1a PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.42782 BP_3 53.92 1.57 1949 642936684 XP_001807897.2 847 7.7e-88 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18120 217 3.6e-16 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF06423//PF01536 GWT1//Adenosylmethionine decarboxylase GO:0006525//GO:0008295//GO:0006560//GO:0006506//GO:0006597 arginine metabolic process//spermidine biosynthetic process//proline metabolic process//GPI anchor biosynthetic process//spermine biosynthetic process GO:0004014//GO:0016746 adenosylmethionine decarboxylase activity//transferase activity, transferring acyl groups GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.42783 BP_3 876.30 11.04 4116 270011364 EFA07812.1 3337 0.0e+00 hypothetical protein TcasGA2_TC005373 [Tribolium castaneum] 749776083 XM_011144769.1 306 1.46985e-156 PREDICTED: Harpegnathos saltator probable ATP-dependent RNA helicase DDX46 (LOC105185358), transcript variant X2, mRNA K12811 DDX46, PRP5 ATP-dependent RNA helicase DDX46/PRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K12811 Q7L014 2441 9.8e-274 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens GN=DDX46 PE=1 SV=2 PF00270 DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676 ATP binding//nucleic acid binding -- -- KOG0334 RNA helicase Cluster-8309.42784 BP_3 87.95 1.06 4280 270011364 EFA07812.1 3337 0.0e+00 hypothetical protein TcasGA2_TC005373 [Tribolium castaneum] 749776083 XM_011144769.1 306 1.52893e-156 PREDICTED: Harpegnathos saltator probable ATP-dependent RNA helicase DDX46 (LOC105185358), transcript variant X2, mRNA K12811 DDX46, PRP5 ATP-dependent RNA helicase DDX46/PRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K12811 Q7L014 2441 1.0e-273 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens GN=DDX46 PE=1 SV=2 PF00270 DEAD/DEAH box helicase -- -- GO:0003676//GO:0005524 nucleic acid binding//ATP binding -- -- KOG0334 RNA helicase Cluster-8309.42785 BP_3 49.28 0.60 4227 270011364 EFA07812.1 1818 4.3e-200 hypothetical protein TcasGA2_TC005373 [Tribolium castaneum] 347972452 XM_311375.5 72 1.81473e-26 Anopheles gambiae str. PEST AGAP010656-PA (AgaP_AGAP010656) mRNA, partial cds K12811 DDX46, PRP5 ATP-dependent RNA helicase DDX46/PRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K12811 Q7L014 1266 1.8e-137 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens GN=DDX46 PE=1 SV=2 PF00270 DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676 ATP binding//nucleic acid binding -- -- KOG0334 RNA helicase Cluster-8309.42788 BP_3 63.70 0.88 3783 546680789 ERL90995.1 1581 1.2e-172 hypothetical protein D910_08337 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 288 4.1e-24 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 PF00856//PF00089 SET domain//Trypsin GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.42790 BP_3 60.00 0.96 3292 282720995 NP_001164248.1 1593 4.1e-174 cytochrome P450 9Z4 [Tribolium castaneum]>gi|270012794|gb|EFA09242.1| cytochrome P450 9Z4 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1098 4.2e-118 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF05374 Cytochrome P450//Mu-Conotoxin GO:0009405//GO:0006810//GO:0055114 pathogenesis//transport//oxidation-reduction process GO:0016705//GO:0016491//GO:0005506//GO:0046872//GO:0020037//GO:0019871 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//iron ion binding//metal ion binding//heme binding//sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.42794 BP_3 10179.00 44.16 11402 642916133 XP_008190900.1 13009 0.0e+00 PREDICTED: laminin subunit alpha [Tribolium castaneum] -- -- -- -- -- K06240 LAMA3_5 laminin, alpha 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K06240 Q00174 7920 0.0e+00 Laminin subunit alpha OS=Drosophila melanogaster GN=LanA PE=1 SV=2 PF06667//PF06008//PF04136//PF04384//PF06009 Phage shock protein B//Laminin Domain I//Sec34-like family//Iron-sulphur cluster assembly//Laminin Domain II GO:0006355//GO:0007155//GO:0030155//GO:0045995//GO:0009271//GO:0016226//GO:0007165//GO:0030334//GO:0006886 regulation of transcription, DNA-templated//cell adhesion//regulation of cell adhesion//regulation of embryonic development//phage shock//iron-sulfur cluster assembly//signal transduction//regulation of cell migration//intracellular protein transport GO:0005102 receptor binding GO:0005801//GO:0016020 cis-Golgi network//membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.42795 BP_3 36.79 0.46 4131 189237657 XP_001812177.1 794 2.3e-81 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 352 1.7e-31 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01428//PF01536 AN1-like Zinc finger//Adenosylmethionine decarboxylase GO:0006525//GO:0006560//GO:0006597//GO:0008295 arginine metabolic process//proline metabolic process//spermine biosynthetic process//spermidine biosynthetic process GO:0008270//GO:0004014 zinc ion binding//adenosylmethionine decarboxylase activity -- -- KOG3183 Predicted Zn-finger protein Cluster-8309.42796 BP_3 42.10 0.33 6468 642934045 XP_008197618.1 1078 4.2e-114 PREDICTED: kelch-like protein 38 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 232 2.2e-17 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF01344//PF13606//PF00651//PF07646//PF00023//PF01370 Kelch motif//Ankyrin repeat//BTB/POZ domain//Kelch motif//Ankyrin repeat//NAD dependent epimerase/dehydratase family -- -- GO:0005515//GO:0003824//GO:0050662 protein binding//catalytic activity//coenzyme binding -- -- KOG4177 Ankyrin Cluster-8309.42798 BP_3 179.75 18.91 750 91086893 XP_970527.1 454 1.1e-42 PREDICTED: protein CDV3 homolog isoform X2 [Tribolium castaneum]>gi|270009679|gb|EFA06127.1| hypothetical protein TcasGA2_TC008970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42799 BP_3 1000.96 14.06 3722 546684210 ERL93915.1 1800 4.6e-198 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 119 1.19095e-52 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1311 9.5e-143 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF00614//PF00412 Phospholipase D Active site motif//LIM domain -- -- GO:0003824//GO:0008270 catalytic activity//zinc ion binding -- -- KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.42800 BP_3 241.00 1.95 6261 642920713 XP_008192532.1 261 2.2e-19 PREDICTED: uncharacterized protein LOC103312793 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42802 BP_3 9.66 0.69 964 642920713 XP_008192532.1 523 1.4e-50 PREDICTED: uncharacterized protein LOC103312793 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42806 BP_3 845.23 7.91 5445 642940052 XP_008200969.1 2913 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 1.8e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF07728//PF01695//PF06068//PF05496//PF00439//PF00004//PF07724//PF00005//PF04851//PF00910 AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Bromodomain//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ABC transporter//Type III restriction enzyme, res subunit//RNA helicase GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0016887//GO:0003724//GO:0009378//GO:0003723//GO:0003678//GO:0005524//GO:0003677//GO:0016787//GO:0005515 ATPase activity//RNA helicase activity//four-way junction helicase activity//RNA binding//DNA helicase activity//ATP binding//DNA binding//hydrolase activity//protein binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.42808 BP_3 58.01 3.29 1141 478256608 ENN76790.1 343 1.2e-29 hypothetical protein YQE_06631, partial [Dendroctonus ponderosae] 462333164 APGK01039067.1 96 2.18469e-40 Dendroctonus ponderosae Seq01039077, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42810 BP_3 119.53 1.15 5306 642934118 XP_008199283.1 1895 6.3e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1299 3.3e-141 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.42811 BP_3 13.29 1.38 757 282158091 NP_001164089.1 411 1.1e-37 farnesyl pyrophosphate synthase [Tribolium castaneum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 Q92250 320 1.6e-28 Farnesyl pyrophosphate synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=fpp PE=3 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.42812 BP_3 374.00 9.85 2121 403234001 AFR31785.1 1015 2.8e-107 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 Q8WMY2 572 2.7e-57 Farnesyl pyrophosphate synthase OS=Bos taurus GN=FDPS PE=1 SV=1 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.42814 BP_3 10.01 0.33 1772 332374874 AEE62578.1 590 4.4e-58 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1HRV8 391 2.2e-36 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01036//PF01151 Bacteriorhodopsin-like protein//GNS1/SUR4 family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.42816 BP_3 2621.69 69.46 2111 332375919 AEE63100.1 2238 4.2e-249 unknown [Dendroctonus ponderosae]>gi|478263200|gb|ENN81590.1| hypothetical protein YQE_02000, partial [Dendroctonus ponderosae]>gi|546674112|gb|ERL85582.1| hypothetical protein D910_03001 [Dendroctonus ponderosae] 826407846 XM_012667203.1 410 0 PREDICTED: Monomorium pharaonis AP-2 complex subunit mu (LOC105828717), transcript variant X2, mRNA K11826 AP2M1 AP-2 complex subunit mu-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11826 Q5ZMP6 1996 2.0e-222 AP-2 complex subunit mu OS=Gallus gallus GN=AP2M1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0938 Adaptor complexes medium subunit family Cluster-8309.42817 BP_3 1350.27 10.64 6411 332375100 AEE62691.1 2046 2.4e-226 unknown [Dendroctonus ponderosae] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 1039 5.7e-111 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF01061//PF01926//PF13304//PF00005//PF03193//PF08031 ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258//Berberine and berberine like GO:0055114 oxidation-reduction process GO:0005525//GO:0016887//GO:0050660//GO:0005524//GO:0003924//GO:0016491 GTP binding//ATPase activity//flavin adenine dinucleotide binding//ATP binding//GTPase activity//oxidoreductase activity GO:0016020 membrane -- -- Cluster-8309.42819 BP_3 41.83 6.78 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42821 BP_3 1397.87 13.57 5257 91090366 XP_968305.1 2290 9.8e-255 PREDICTED: T-cell immunomodulatory protein [Tribolium castaneum]>gi|270013408|gb|EFA09856.1| hypothetical protein TcasGA2_TC012004 [Tribolium castaneum] 765338960 XM_011495191.1 147 4.59175e-68 Aedes aegypti AAEL017098-RA partial mRNA K17257 ITFG1 integrin alpha FG-GAP repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17257 P18459 993 1.0e-105 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00351 Biopterin-dependent aromatic amino acid hydroxylase GO:0055114 oxidation-reduction process GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.42824 BP_3 1011.55 6.92 7336 642922200 XP_008193059.1 2412 9.8e-269 PREDICTED: patronin isoform X6 [Tribolium castaneum] 645007691 XM_008218148.1 77 5.24974e-29 PREDICTED: Nasonia vitripennis patronin (LOC100118026), mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 1217 1.5e-131 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF17095 Spectrin-binding region of Ca2+-Calmodulin GO:0031175 neuron projection development GO:0005516//GO:0030507 calmodulin binding//spectrin binding GO:0008091 spectrin KOG3654 Uncharacterized CH domain protein Cluster-8309.42825 BP_3 5.00 1.28 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42827 BP_3 6.00 0.44 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42829 BP_3 242.88 2.55 4886 801375633 XP_012063602.1 310 3.6e-25 PREDICTED: zinc finger protein 2-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- Q9CXE0 278 7.6e-23 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF00130//PF00096//PF05715//PF08996//PF06061//PF07776//PF13465//PF01844//PF02892//PF13912//PF01363 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Piccolo Zn-finger//DNA Polymerase alpha zinc finger//Baculoviridae ME53//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//HNH endonuclease//BED zinc finger//C2H2-type zinc finger//FYVE zinc finger GO:0035556//GO:0006260 intracellular signal transduction//DNA replication GO:0046872//GO:0001882//GO:0003676//GO:0008270//GO:0003887//GO:0003677//GO:0004519 metal ion binding//nucleoside binding//nucleic acid binding//zinc ion binding//DNA-directed DNA polymerase activity//DNA binding//endonuclease activity GO:0045202//GO:0042575//GO:0005634 synapse//DNA polymerase complex//nucleus -- -- Cluster-8309.42830 BP_3 1778.03 24.89 3735 270001368 EEZ97815.1 2868 0.0e+00 hypothetical protein TcasGA2_TC000182 [Tribolium castaneum] 170046948 XM_001850953.1 142 1.95792e-65 Culex quinquefasciatus tyrosine phosphatase n9, mRNA K18038 PTPN9, MEG2 tyrosine-protein phosphatase non-receptor type 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18038 Q641Z2 1365 5.2e-149 Tyrosine-protein phosphatase non-receptor type 9 OS=Rattus norvegicus GN=Ptpn9 PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.42832 BP_3 536.66 6.72 4143 642935662 XP_008198105.1 1005 7.8e-106 PREDICTED: cytochrome b reductase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 3.1e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF00033//PF03188//PF01292 Cytochrome b/b6/petB//Eukaryotic cytochrome b561//Prokaryotic cytochrome b561 GO:0022904//GO:0006118 respiratory electron transport chain//obsolete electron transport GO:0009055 electron carrier activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1619 Cytochrome b Cluster-8309.42833 BP_3 997.53 24.84 2227 642934951 XP_008195932.1 2525 2.3e-282 PREDICTED: protein MTO1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03495 gidA, mnmG, MTO1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K03495 Q4R4P6 1807 1.7e-200 Protein MTO1 homolog, mitochondrial OS=Macaca fascicularis GN=MTO1 PE=2 SV=1 PF00070//PF12831//PF01134//PF07992//PF05834 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein GO:0055114//GO:0008033//GO:0016117 oxidation-reduction process//tRNA processing//carotenoid biosynthetic process GO:0016491//GO:0016705//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding -- -- KOG2311 NAD/FAD-utilizing protein possibly involved in translation Cluster-8309.42834 BP_3 19.25 0.46 2314 642934951 XP_008195932.1 1438 2.7e-156 PREDICTED: protein MTO1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03495 gidA, mnmG, MTO1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K03495 Q4R4P6 1045 4.1e-112 Protein MTO1 homolog, mitochondrial OS=Macaca fascicularis GN=MTO1 PE=2 SV=1 PF01134//PF01059//PF07992//PF05834 Glucose inhibited division protein A//NADH-ubiquinone oxidoreductase chain 4, amino terminus//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein GO:0055114//GO:0008033//GO:0006120//GO:0016117 oxidation-reduction process//tRNA processing//mitochondrial electron transport, NADH to ubiquinone//carotenoid biosynthetic process GO:0016491//GO:0016705//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding -- -- KOG2311 NAD/FAD-utilizing protein possibly involved in translation Cluster-8309.42835 BP_3 33.02 2.23 1005 270015890 EFA12338.1 843 1.2e-87 hypothetical protein TcasGA2_TC016023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12297 430 3.7e-41 Protein suppressor of white apricot OS=Drosophila melanogaster GN=su(w[a]) PE=1 SV=3 PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG1847 mRNA splicing factor Cluster-8309.42837 BP_3 18.38 0.31 3184 91087297 XP_975561.1 2707 2.6e-303 PREDICTED: protein fem-1 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K10349 FEM1B Fem-1 homolog b http://www.genome.jp/dbget-bin/www_bget?ko:K10349 Q5ZM55 1739 1.9e-192 Protein fem-1 homolog B OS=Gallus gallus GN=FEM1B PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.42838 BP_3 160.37 3.62 2426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42840 BP_3 32.71 0.55 3145 91076494 XP_972946.1 151 6.3e-07 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05208 ALG3 protein -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.42841 BP_3 78.00 5.45 981 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42844 BP_3 279.04 4.69 3157 91087297 XP_975561.1 2727 1.3e-305 PREDICTED: protein fem-1 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K10349 FEM1B Fem-1 homolog b http://www.genome.jp/dbget-bin/www_bget?ko:K10349 Q5ZM55 1759 9.1e-195 Protein fem-1 homolog B OS=Gallus gallus GN=FEM1B PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.42845 BP_3 6.00 0.78 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08172 CASP C terminal GO:0006891 intra-Golgi vesicle-mediated transport -- -- GO:0030173 integral component of Golgi membrane -- -- Cluster-8309.42846 BP_3 8.37 0.46 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42847 BP_3 271.29 3.23 4345 91076494 XP_972946.1 151 8.7e-07 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42852 BP_3 107.23 0.71 7575 769835915 XP_011648080.1 1279 2.4e-137 PREDICTED: uncharacterized protein LOC105434147 [Pogonomyrmex barbatus] 642922119 XM_008194802.1 71 1.17358e-25 PREDICTED: Tribolium castaneum uncharacterized LOC103312925 (LOC103312925), mRNA -- -- -- -- M9NEY8 1073 7.7e-115 DNA N6-methyl adenine demethylase OS=Drosophila melanogaster GN=Tet PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42853 BP_3 89.31 0.65 6946 102939 1496 1.5e-162 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1171 3.0e-126 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF04137//PF03310//PF13683//PF00665//PF02966 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//Caulimovirus DNA-binding protein//Integrase core domain//Integrase core domain//Mitosis protein DIM1 GO:0015074//GO:0000398//GO:0055114 DNA integration//mRNA splicing, via spliceosome//oxidation-reduction process GO:0003756//GO:0016671//GO:0003677 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//DNA binding GO:0005783//GO:0005681 endoplasmic reticulum//spliceosomal complex -- -- Cluster-8309.42855 BP_3 64.59 0.36 9000 478255227 ENN75456.1 8616 0.0e+00 hypothetical protein YQE_08006, partial [Dendroctonus ponderosae] 759045107 XM_011333192.1 97 4.91348e-40 PREDICTED: Cerapachys biroi protein sidekick (LOC105275958), transcript variant X4, mRNA K16353 SDK protein sidekick http://www.genome.jp/dbget-bin/www_bget?ko:K16353 O97394 7061 0.0e+00 Protein sidekick OS=Drosophila melanogaster GN=sdk PE=1 SV=2 PF02404//PF16656//PF00041//PF07354//PF13895//PF07646 Stem cell factor//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Kelch motif GO:0007165//GO:0019497//GO:0007339//GO:0006771//GO:0007155 signal transduction//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//riboflavin metabolic process//cell adhesion GO:0005173//GO:0005515//GO:0003993//GO:0046872 stem cell factor receptor binding//protein binding//acid phosphatase activity//metal ion binding GO:0016020//GO:0005576 membrane//extracellular region KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.42856 BP_3 117.88 2.74 2365 91093909 XP_970018.1 939 2.0e-98 PREDICTED: cation transport regulator-like protein 1 [Tribolium castaneum]>gi|270014507|gb|EFA10955.1| hypothetical protein TcasGA2_TC004115 [Tribolium castaneum] -- -- -- -- -- K07232 chaC cation transport protein ChaC http://www.genome.jp/dbget-bin/www_bget?ko:K07232 Q9BUX1 467 4.5e-45 Glutathione-specific gamma-glutamylcyclotransferase 1 OS=Homo sapiens GN=CHAC1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3182 Predicted cation transporter Cluster-8309.42859 BP_3 440.51 2.10 10398 546684972 ERL94546.1 4054 0.0e+00 hypothetical protein D910_11823 [Dendroctonus ponderosae] 768442001 XM_011564452.1 506 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q9Z1N3 1894 6.6e-210 Unconventional myosin-IXa OS=Rattus norvegicus GN=Myo9a PE=1 SV=1 PF00620//PF00788//PF09280//PF02954//PF15177//PF00612//PF12678//PF07649//PF00063//PF00628//PF00437//PF00130 RhoGAP domain//Ras association (RalGDS/AF-6) domain//XPC-binding domain//Bacterial regulatory protein, Fis family//Interleukin-28A//IQ calmodulin-binding motif//RING-H2 zinc finger//C1-like domain//Myosin head (motor domain)//PHD-finger//Type II/IV secretion system protein//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007259//GO:0051607//GO:0050778//GO:0043161//GO:0006289//GO:0007165//GO:0006281//GO:0006810//GO:0055114//GO:0035556 JAK-STAT cascade//defense response to virus//positive regulation of immune response//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair//signal transduction//DNA repair//transport//oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0003774//GO:0003684//GO:0005524//GO:0005125//GO:0043565//GO:0008270//GO:0047134 protein binding//motor activity//damaged DNA binding//ATP binding//cytokine activity//sequence-specific DNA binding//zinc ion binding//protein-disulfide reductase activity GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.4286 BP_3 12.00 0.60 1263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42864 BP_3 95.41 1.00 4890 642939097 XP_008200220.1 2017 4.1e-223 PREDICTED: uncharacterized protein LOC658083 isoform X1 [Tribolium castaneum]>gi|642939099|ref|XP_008200221.1| PREDICTED: uncharacterized protein LOC658083 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10719 JHEH juvenile hormone epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K10719 Q8MZR5 1230 3.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.42865 BP_3 187.76 9.45 1249 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42868 BP_3 878.72 17.67 2688 642919711 XP_008192032.1 1828 1.9e-201 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [Tribolium castaneum]>gi|270005898|gb|EFA02346.1| hypothetical protein TcasGA2_TC008016 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.4e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.4287 BP_3 9.40 0.38 1471 270004805 EFA01253.1 1498 1.9e-163 hypothetical protein TcasGA2_TC002449 [Tribolium castaneum] -- -- -- -- -- K04984 TRPA1, ANKTM1 transient receptor potential cation channel subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04984 Q7Z020 1151 1.3e-124 Transient receptor potential cation channel subfamily A member 1 OS=Drosophila melanogaster GN=TrpA1 PE=2 SV=4 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.42870 BP_3 62.04 1.10 3010 478258252 ENN78381.1 1023 4.7e-108 hypothetical protein YQE_05182, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 212 2.1e-15 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.42871 BP_3 516.96 6.48 4139 91078224 XP_969612.1 1927 9.6e-213 PREDICTED: cell division cycle protein 20 homolog [Tribolium castaneum]>gi|270002363|gb|EEZ98810.1| hypothetical protein TcasGA2_TC001383 [Tribolium castaneum] -- -- -- -- -- K03363 CDC20 cell division cycle 20, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03363 Q62623 1377 2.4e-150 Cell division cycle protein 20 homolog OS=Rattus norvegicus GN=Cdc20 PE=1 SV=2 PF00400//PF00498 WD domain, G-beta repeat//FHA domain -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.42872 BP_3 1053.56 31.00 1930 546678419 ERL89042.1 305 5.4e-25 hypothetical protein D910_06420 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1ZB86 192 2.8e-13 Kelch domain-containing protein 10 homolog OS=Drosophila melanogaster GN=slim PE=1 SV=1 PF07646//PF01344 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42873 BP_3 43.87 0.41 5483 642920861 XP_008192589.1 3650 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 630 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3150 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF16656//PF02480//PF07353//PF00041//PF07354//PF13895 Tissue factor//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Uroplakin II//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain GO:0019497//GO:0007339//GO:0006771//GO:0061024 hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//riboflavin metabolic process//membrane organization GO:0005515//GO:0003993//GO:0046872 protein binding//acid phosphatase activity//metal ion binding GO:0030176//GO:0016020//GO:0005576 integral component of endoplasmic reticulum membrane//membrane//extracellular region -- -- Cluster-8309.42874 BP_3 23.26 0.95 1466 642911657 XP_001810552.2 706 1.3e-71 PREDICTED: double-stranded RNA-binding protein Staufen homolog 2 isoform X3 [Tribolium castaneum] 642911656 XM_001810500.2 147 1.25893e-68 PREDICTED: Tribolium castaneum staufen (LOC657623), transcript variant X3, mRNA K17597 STAU double-stranded RNA-binding protein Staufen http://www.genome.jp/dbget-bin/www_bget?ko:K17597 P25159 327 4.7e-29 Maternal effect protein staufen OS=Drosophila melanogaster GN=stau PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3732 Staufen and related double-stranded-RNA-binding proteins Cluster-8309.42875 BP_3 148.76 1.12 6668 821117180 XP_012382122.1 458 3.4e-42 PREDICTED: zinc finger protein 883-like [Dasypus novemcinctus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8C827 422 2.1e-39 Zinc finger protein 62 OS=Mus musculus GN=Zfp62 PE=2 SV=1 PF13912//PF07776//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.42876 BP_3 2142.87 29.91 3745 642938770 XP_008199881.1 1708 2.1e-187 PREDICTED: protein transport protein Sec16B-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15027 945 2.6e-100 Protein transport protein Sec16A OS=Homo sapiens GN=SEC16A PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1913 Regucalcin gene promoter region-related protein (RGPR) Cluster-8309.42879 BP_3 1316.97 18.40 3741 546673559 ERL85134.1 865 1.2e-89 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42880 BP_3 31.86 0.50 3344 478256729 ENN76910.1 1157 1.5e-123 hypothetical protein YQE_06557, partial [Dendroctonus ponderosae]>gi|546672603|gb|ERL84404.1| hypothetical protein D910_01837 [Dendroctonus ponderosae] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 300 1.5e-25 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF04848//PF03137//PF07690 Poxvirus A22 protein//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0006810//GO:0006281//GO:0055085//GO:0006310 transport//DNA repair//transmembrane transport//DNA recombination GO:0005215//GO:0016788//GO:0000400//GO:0000287 transporter activity//hydrolase activity, acting on ester bonds//four-way junction DNA binding//magnesium ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG2504 Monocarboxylate transporter Cluster-8309.42882 BP_3 228.38 2.30 5072 642936704 XP_008198546.1 2191 2.9e-243 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P07207 145 2.1e-07 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF13895//PF02793//PF00008 Immunoglobulin domain//Hormone receptor domain//EGF-like domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016020 membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.42885 BP_3 823.06 13.02 3338 170032167 XP_001843954.1 1582 7.8e-173 conserved hypothetical protein [Culex quinquefasciatus]>gi|167871903|gb|EDS35286.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P30839 1294 8.0e-141 Fatty aldehyde dehydrogenase OS=Rattus norvegicus GN=Aldh3a2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0044710//GO:0008152//GO:0055114 single-organism metabolic process//metabolic process//oxidation-reduction process GO:0016620//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.42886 BP_3 4880.11 60.25 4196 91079020 XP_974879.1 1901 1.0e-209 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q7ZT42 1171 1.8e-126 Staphylococcal nuclease domain-containing protein 1 OS=Danio rerio GN=snd1 PE=2 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.42888 BP_3 25.46 0.36 3741 189235428 XP_001812612.1 3976 0.0e+00 PREDICTED: importin-4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEX9 1377 2.1e-150 Importin-4 OS=Homo sapiens GN=IPO4 PE=1 SV=2 PF03810//PF01347//PF02985//PF07836//PF00514 Importin-beta N-terminal domain//Lipoprotein amino terminal region//HEAT repeat//DmpG-like communication domain//Armadillo/beta-catenin-like repeat GO:0006886//GO:0006869//GO:0019439 intracellular protein transport//lipid transport//aromatic compound catabolic process GO:0005515//GO:0016833//GO:0008536//GO:0005319 protein binding//oxo-acid-lyase activity//Ran GTPase binding//lipid transporter activity -- -- KOG2171 Karyopherin (importin) beta 3 Cluster-8309.42889 BP_3 2219.29 32.90 3543 478250976 ENN71460.1 1089 1.2e-115 hypothetical protein YQE_11877, partial [Dendroctonus ponderosae]>gi|546682655|gb|ERL92567.1| hypothetical protein D910_09880 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P46941 324 2.5e-28 WW domain-containing protein tag-325 OS=Caenorhabditis elegans GN=tag-325 PE=3 SV=1 PF02749//PF00620 Quinolinate phosphoribosyl transferase, N-terminal domain//RhoGAP domain GO:0007165 signal transduction GO:0016763 transferase activity, transferring pentosyl groups -- -- KOG1450 Predicted Rho GTPase-activating protein Cluster-8309.42890 BP_3 79.46 2.12 2096 478259873 ENN79691.1 473 1.9e-44 hypothetical protein YQE_03871, partial [Dendroctonus ponderosae]>gi|478260329|gb|ENN80079.1| hypothetical protein YQE_03487, partial [Dendroctonus ponderosae]>gi|478266524|gb|ENN82814.1| hypothetical protein YQE_00818, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24799 267 6.1e-22 Myophilin OS=Echinococcus granulosus PE=2 SV=1 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.42894 BP_3 131.15 1.37 4921 478251097 ENN71573.1 1384 1.0e-149 hypothetical protein YQE_11673, partial [Dendroctonus ponderosae] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 209 7.7e-15 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF00466//PF09402 Ribosomal protein L10//Man1-Src1p-C-terminal domain GO:0042254 ribosome biogenesis -- -- GO:0005622//GO:0005639 intracellular//integral component of nuclear inner membrane -- -- Cluster-8309.42895 BP_3 729.30 29.43 1486 546683208 ERL93048.1 494 5.0e-47 hypothetical protein D910_10350 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4290 BP_3 5.00 0.62 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42900 BP_3 270.60 4.30 3323 91093076 XP_968784.1 903 4.2e-94 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] 195036913 XM_001989877.1 35 5.26601e-06 Drosophila grimshawi GH18533 (Dgri\GH18533), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 844 1.2e-88 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42901 BP_3 453.03 6.96 3427 642918312 XP_008191454.1 2864 0.0e+00 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.09751e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1917 4.7e-213 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.42903 BP_3 13.19 0.36 2075 270014138 EFA10586.1 919 3.7e-96 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936569 XM_008200268.1 184 4.8507e-89 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X2, mRNA -- -- -- -- P55202 325 1.1e-28 Atrial natriuretic peptide receptor 2 OS=Anguilla japonica GN=npr2 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.42904 BP_3 783.89 27.72 1655 332376633 AEE63456.1 1923 1.1e-212 unknown [Dendroctonus ponderosae] 195434135 XM_002065023.1 48 1.54054e-13 Drosophila willistoni GK15257 (Dwil\GK15257), mRNA -- -- -- -- Q96P53 1238 1.2e-134 WD repeat and FYVE domain-containing protein 2 OS=Homo sapiens GN=WDFY2 PE=2 SV=2 PF00400//PF07365//PF01363 WD domain, G-beta repeat//Alpha conotoxin precursor//FYVE zinc finger GO:0007268//GO:0009405//GO:0007165 synaptic transmission//pathogenesis//signal transduction GO:0030550//GO:0005515//GO:0046872 acetylcholine receptor inhibitor activity//protein binding//metal ion binding GO:0005576 extracellular region KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.42905 BP_3 937.20 41.21 1388 332373814 AEE62048.1 1915 7.9e-212 unknown [Dendroctonus ponderosae] 194896197 XM_001978396.1 323 1.72901e-166 Drosophila erecta GG17681 (Dere\GG17681), mRNA K03064 PSMC6, RPT4 26S proteasome regulatory subunit T4 http://www.genome.jp/dbget-bin/www_bget?ko:K03064 P62335 1794 3.5e-199 26S protease regulatory subunit 10B OS=Spermophilus tridecemlineatus GN=PSMC6 PE=2 SV=1 PF00004//PF13851//PF07724//PF01695//PF07728//PF05496//PF00158//PF06068//PF01432//PF00910//PF07726//PF02562//PF01637//PF02367 ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//Peptidase family M3//RNA helicase//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006355//GO:0006281//GO:0002949//GO:0006310//GO:0006508//GO:0048870 regulation of transcription, DNA-templated//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis//cell motility GO:0016887//GO:0008134//GO:0005524//GO:0004222//GO:0009378//GO:0003724//GO:0003678//GO:0003723 ATPase activity//transcription factor binding//ATP binding//metalloendopeptidase activity//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding GO:0009379//GO:0031514//GO:0005667//GO:0005657 Holliday junction helicase complex//motile cilium//transcription factor complex//replication fork KOG0651 26S proteasome regulatory complex, ATPase RPT4 Cluster-8309.42907 BP_3 877.89 29.71 1716 86515410 NP_001034529.1 1464 1.9e-159 cytochrome P450, family 4, subfamily Q, polypeptide 4 precursor [Tribolium castaneum]>gi|7804914|gb|AAF70178.1|AF251548_1 cytochrome P450 monooxigenase CYP4Q4 [Tribolium castaneum] 826490357 XM_012684512.1 42 3.46025e-10 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105838744), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1024 8.3e-110 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0046872//GO:0016705 heme binding//iron ion binding//oxidoreductase activity//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.42908 BP_3 52.41 1.35 2158 86515410 NP_001034529.1 1464 2.4e-159 cytochrome P450, family 4, subfamily Q, polypeptide 4 precursor [Tribolium castaneum]>gi|7804914|gb|AAF70178.1|AF251548_1 cytochrome P450 monooxigenase CYP4Q4 [Tribolium castaneum] 826490357 XM_012684512.1 42 4.37008e-10 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105838744), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1024 1.0e-109 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0005506//GO:0020037//GO:0016705 metal ion binding//oxidoreductase activity//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.42909 BP_3 82.44 2.30 2018 91079304 XP_966317.1 1435 5.2e-156 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 648 3.9e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.42911 BP_3 178.00 4.02 2426 282158109 NP_001164098.1 2402 4.7e-268 heat shock protein TC005094 [Tribolium castaneum]>gi|270015405|gb|EFA11853.1| hypothetical protein TcasGA2_TC005094 [Tribolium castaneum] 113208384 AB251895.1 568 0 Mamestra brassicae hsp70 mRNA for heat shock protein 70, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 O97125 2184 3.7e-244 Heat shock protein 68 OS=Drosophila melanogaster GN=Hsp68 PE=1 SV=1 PF01968//PF06723 Hydantoinase/oxoprolinase//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0005524//GO:0016787 ATP binding//hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.42913 BP_3 864.17 11.90 3791 478254766 ENN75003.1 1130 2.3e-120 hypothetical protein YQE_08460, partial [Dendroctonus ponderosae] 462318734 APGK01044304.1 89 5.76577e-36 Dendroctonus ponderosae Seq01044314, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF00158 Sigma-54 interaction domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0008134 ATP binding//transcription factor binding GO:0005667 transcription factor complex -- -- Cluster-8309.42915 BP_3 692.94 20.29 1938 546673062 ERL84739.1 613 1.0e-60 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 324 1.4e-28 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF01764//PF02230//PF07859//PF00326//PF03583//PF11112 Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family//Secretory lipase//Pyocin activator protein PrtN GO:0006629//GO:0008152//GO:0046486//GO:0006355//GO:0006508//GO:0016042 lipid metabolic process//metabolic process//glycerolipid metabolic process//regulation of transcription, DNA-templated//proteolysis//lipid catabolic process GO:0004806//GO:0016787//GO:0008236 triglyceride lipase activity//hydrolase activity//serine-type peptidase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.42917 BP_3 753.67 5.83 6523 332372760 AEE61522.1 509 4.0e-48 unknown [Dendroctonus ponderosae]>gi|478251664|gb|ENN72118.1| hypothetical protein YQE_11177, partial [Dendroctonus ponderosae]>gi|478262743|gb|ENN81274.1| hypothetical protein YQE_02310, partial [Dendroctonus ponderosae]>gi|546680918|gb|ERL91092.1| hypothetical protein D910_08434 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38718 366 6.3e-33 Mitochondrial pyruvate carrier 2 OS=Rattus norvegicus GN=Mpc2 PE=2 SV=1 PF03650//PF02790 Uncharacterised protein family (UPF0041)//Cytochrome C oxidase subunit II, transmembrane domain GO:0022900//GO:0006850 electron transport chain//mitochondrial pyruvate transport -- -- GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG1589 Uncharacterized conserved protein Cluster-8309.42919 BP_3 1851.91 15.55 6031 642925932 XP_008194701.1 4700 0.0e+00 PREDICTED: protein son of sevenless [Tribolium castaneum] 642925931 XM_008196479.1 821 0 PREDICTED: Tribolium castaneum protein son of sevenless (LOC662194), mRNA K03099 SOS son of sevenless http://www.genome.jp/dbget-bin/www_bget?ko:K03099 P26675 3237 0.0e+00 Protein son of sevenless OS=Drosophila melanogaster GN=Sos PE=1 SV=2 PF00617//PF00032//PF00621//PF00125 RasGEF domain//Cytochrome b(C-terminal)/b6/petD//RhoGEF domain//Core histone H2A/H2B/H3/H4 GO:0035023//GO:0043087//GO:0006118//GO:0007264 regulation of Rho protein signal transduction//regulation of GTPase activity//obsolete electron transport//small GTPase mediated signal transduction GO:0003677//GO:0005085//GO:0016491//GO:0009055//GO:0005089 DNA binding//guanyl-nucleotide exchange factor activity//oxidoreductase activity//electron carrier activity//Rho guanyl-nucleotide exchange factor activity GO:0016020 membrane KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.42920 BP_3 121.33 1.13 5462 642925932 XP_008194701.1 2145 6.7e-238 PREDICTED: protein son of sevenless [Tribolium castaneum] 642925931 XM_008196479.1 355 0 PREDICTED: Tribolium castaneum protein son of sevenless (LOC662194), mRNA K03099 SOS son of sevenless http://www.genome.jp/dbget-bin/www_bget?ko:K03099 P26675 1425 8.4e-156 Protein son of sevenless OS=Drosophila melanogaster GN=Sos PE=1 SV=2 PF00621//PF06422//PF00032//PF00617//PF03635 RhoGEF domain//CDR ABC transporter//Cytochrome b(C-terminal)/b6/petD//RasGEF domain//Vacuolar protein sorting-associated protein 35 GO:0006118//GO:0042147//GO:0015031//GO:0035023//GO:0006810//GO:0043087//GO:0007264 obsolete electron transport//retrograde transport, endosome to Golgi//protein transport//regulation of Rho protein signal transduction//transport//regulation of GTPase activity//small GTPase mediated signal transduction GO:0008565//GO:0042626//GO:0005524//GO:0009055//GO:0005089//GO:0005085//GO:0016491 protein transporter activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//electron carrier activity//Rho guanyl-nucleotide exchange factor activity//guanyl-nucleotide exchange factor activity//oxidoreductase activity GO:0016021//GO:0030904//GO:0016020 integral component of membrane//retromer complex//membrane KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.42925 BP_3 19.11 3.18 581 646720584 KDR22245.1 138 3.7e-06 GMP reductase 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42926 BP_3 8.00 1.11 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42927 BP_3 47.50 1.46 1855 642915333 XP_008190576.1 659 4.6e-66 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 484 3.7e-47 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 PF00034 Cytochrome c GO:0006118 obsolete electron transport GO:0009055//GO:0020037 electron carrier activity//heme binding -- -- -- -- Cluster-8309.42928 BP_3 75.45 0.90 4313 91083607 XP_969406.1 899 1.6e-93 PREDICTED: solute carrier family 25 member 44 [Tribolium castaneum]>gi|270007841|gb|EFA04289.1| hypothetical protein TcasGA2_TC014580 [Tribolium castaneum] -- -- -- -- -- K15121 SLC25A44 solute carrier family 25, member 44 http://www.genome.jp/dbget-bin/www_bget?ko:K15121 Q5RD67 494 6.0e-48 Solute carrier family 25 member 44 OS=Pongo abelii GN=SLC25A44 PE=2 SV=2 PF00096 Zinc finger, C2H2 type GO:0055085 transmembrane transport GO:0046872 metal ion binding GO:0016021 integral component of membrane KOG0765 Predicted mitochondrial carrier protein Cluster-8309.42929 BP_3 13.61 0.33 2255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668//PF05493 Aspartyl protease//ATP synthase subunit H GO:0015991//GO:0015992//GO:0006508 ATP hydrolysis coupled proton transport//proton transport//proteolysis GO:0015078//GO:0004190 hydrogen ion transmembrane transporter activity//aspartic-type endopeptidase activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.42930 BP_3 13.48 1.23 819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.42933 BP_3 1049.70 21.38 2658 642911645 XP_008200684.1 1455 3.3e-158 PREDICTED: synapse-associated protein of 47 kDa isoform X1 [Tribolium castaneum]>gi|270014579|gb|EFA11027.1| hypothetical protein TcasGA2_TC004616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 565 2.2e-56 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.42934 BP_3 3.02 0.48 595 642911649 XP_008200687.1 208 2.9e-14 PREDICTED: synapse-associated protein of 47 kDa isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42936 BP_3 1057.45 18.27 3081 642926820 XP_008195027.1 2254 8.6e-251 PREDICTED: uncharacterized protein LOC100142170 isoform X2 [Tribolium castaneum]>gi|270008388|gb|EFA04836.1| hypothetical protein TcasGA2_TC014886 [Tribolium castaneum] 642926819 XM_008196805.1 319 6.50937e-164 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096//PF14719 Altered inheritance of mitochondria protein 3//Phosphotyrosine interaction domain (PTB/PID) GO:0051016 barbed-end actin filament capping GO:0005515 protein binding GO:0030479 actin cortical patch -- -- Cluster-8309.42937 BP_3 22.00 9.42 403 642923549 XP_008193554.1 545 1.7e-53 PREDICTED: zinc finger and SCAN domain-containing protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10073 293 1.1e-25 Zinc finger and SCAN domain-containing protein 22 OS=Homo sapiens GN=ZSCAN22 PE=1 SV=2 PF00096//PF05495//PF02892//PF00412//PF13912//PF13465//PF13639//PF07975 Zinc finger, C2H2 type//CHY zinc finger//BED zinc finger//LIM domain//C2H2-type zinc finger//Zinc-finger double domain//Ring finger domain//TFIIH C1-like domain GO:0006281 DNA repair GO:0046872//GO:0005515//GO:0008270//GO:0003677 metal ion binding//protein binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.42938 BP_3 17.80 0.41 2409 344241662 EGV97765.1 506 3.3e-48 Zinc finger protein 845, partial [Cricetulus griseus] 642923548 XM_008195332.1 36 1.0578e-06 PREDICTED: Tribolium castaneum zinc finger and SCAN domain-containing protein 2-like (LOC658870), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P18753 455 1.1e-43 Oocyte zinc finger protein XlCOF8.4 (Fragment) OS=Xenopus laevis PE=2 SV=1 PF00096//PF13465//PF05495//PF13912//PF07776//PF00962 Zinc finger, C2H2 type//Zinc-finger double domain//CHY zinc finger//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Adenosine/AMP deaminase -- -- GO:0008270//GO:0019239//GO:0046872 zinc ion binding//deaminase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.42939 BP_3 308.67 5.62 2939 344241662 EGV97765.1 670 3.9e-67 Zinc finger protein 845, partial [Cricetulus griseus] 642923548 XM_008195332.1 36 1.2931e-06 PREDICTED: Tribolium castaneum zinc finger and SCAN domain-containing protein 2-like (LOC658870), transcript variant X2, mRNA -- -- -- -- P18753 552 7.7e-55 Oocyte zinc finger protein XlCOF8.4 (Fragment) OS=Xenopus laevis PE=2 SV=1 PF13465//PF00096//PF13912//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.42940 BP_3 190.53 3.75 2742 344241662 EGV97765.1 646 2.2e-64 Zinc finger protein 845, partial [Cricetulus griseus] 462390348 APGK01018839.1 38 9.31792e-08 Dendroctonus ponderosae Seq01018849, whole genome shotgun sequence K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9BY31 525 9.7e-52 Zinc finger protein 717 OS=Homo sapiens GN=ZNF717 PE=2 SV=2 PF13912//PF07776//PF13465//PF00096//PF07975 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.42941 BP_3 11.00 0.35 1805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00738 Polyhedrin -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.42943 BP_3 311.32 1.51 10262 642912029 XP_008199066.1 2816 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 345 2.7e-30 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF04319//PF02460//PF03176//PF00873 NifZ domain//Patched family//MMPL family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165//GO:0009399 transport//signal transduction//nitrogen fixation GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.42945 BP_3 79.28 0.68 5917 642920440 XP_008192351.1 1883 1.7e-207 PREDICTED: interference hedgehog-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 847 9.6e-89 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF13895//PF00041//PF16656 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.42947 BP_3 1605.81 6.96 11419 91093513 XP_969441.1 4135 0.0e+00 PREDICTED: RNA polymerase-associated protein CTR9 homolog [Tribolium castaneum]>gi|270002675|gb|EEZ99122.1| hypothetical protein TcasGA2_TC005228 [Tribolium castaneum] 759065906 XM_011344092.1 655 0 PREDICTED: Cerapachys biroi RNA polymerase-associated protein CTR9 homolog (LOC105282240), mRNA K15176 CTR9 RNA polymerase-associated protein CTR9 http://www.genome.jp/dbget-bin/www_bget?ko:K15176 Q4QR29 3306 0.0e+00 RNA polymerase-associated protein CTR9 homolog OS=Xenopus laevis GN=ctr9 PE=2 SV=1 PF00892//PF13174//PF05009//PF06027//PF07721//PF13181//PF10579//PF13176//PF05887//PF13414//PF00515//PF13374 EamA-like transporter family//Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Solute carrier family 35//Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Procyclic acidic repetitive protein (PARP)//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006810//GO:0007268//GO:0016032 transport//synaptic transmission//viral process GO:0043495//GO:0005515//GO:0033130//GO:0042802 protein anchor//protein binding//acetylcholine receptor binding//identical protein binding GO:0016020//GO:0042025//GO:0016021 membrane//host cell nucleus//integral component of membrane KOG2002 TPR-containing nuclear phosphoprotein that regulates K(+) uptake Cluster-8309.42949 BP_3 3.00 1.82 368 91089625 XP_973443.1 323 8.4e-28 PREDICTED: tudor and KH domain-containing protein [Tribolium castaneum]>gi|270012611|gb|EFA09059.1| hypothetical protein TcasGA2_TC006774 [Tribolium castaneum] -- -- -- -- -- K18406 TDRKH, TDRD2 tudor domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18406 Q9Y2W6 129 1.1e-06 Tudor and KH domain-containing protein OS=Homo sapiens GN=TDRKH PE=1 SV=2 -- -- -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.42950 BP_3 225.26 1.97 5801 642936624 XP_008198511.1 2966 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.17895e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.9e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF02346//PF01166 Chordopoxvirus multifunctional envelope protein A27//TSC-22/dip/bun family GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.42951 BP_3 298.12 3.56 4331 642924482 XP_008194314.1 222 5.1e-15 PREDICTED: protein ELYS isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05210 Sprouty protein (Spry) GO:0007275//GO:0009966 multicellular organismal development//regulation of signal transduction -- -- GO:0016020 membrane -- -- Cluster-8309.42952 BP_3 648.00 23.18 1639 282403505 NP_001164149.1 1680 1.7e-184 fumble isoform 2 [Tribolium castaneum]>gi|642912443|ref|XP_008200862.1| PREDICTED: fumble isoform X2 [Tribolium castaneum] 746854770 XM_011059724.1 126 6.65888e-57 PREDICTED: Acromyrmex echinatior pantothenate kinase 3 (LOC105148170), transcript variant X9, mRNA K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q8TE04 1160 1.4e-125 Pantothenate kinase 1 OS=Homo sapiens GN=PANK1 PE=1 SV=2 PF03630 Fumble GO:0015937//GO:0015940 coenzyme A biosynthetic process//pantothenate biosynthetic process GO:0004594//GO:0005524 pantothenate kinase activity//ATP binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.42954 BP_3 2360.15 11.71 10007 546685894 ERL95319.1 2308 1.5e-256 hypothetical protein D910_12585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MSS1 521 1.0e-50 Protein lava lamp OS=Drosophila melanogaster GN=lva PE=1 SV=2 PF06463 Molybdenum Cofactor Synthesis C GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0051539 4 iron, 4 sulfur cluster binding GO:0019008 molybdopterin synthase complex -- -- Cluster-8309.42956 BP_3 765.32 11.99 3368 642928849 XP_008195587.1 3047 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 16 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15159 MED16 mediator of RNA polymerase II transcription subunit 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15159 Q16K67 1494 5.2e-164 Mediator of RNA polymerase II transcription subunit 16 OS=Aedes aegypti GN=MED16 PE=3 SV=1 PF00830 Ribosomal L28 family GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.42957 BP_3 104.58 1.08 4961 642931172 XP_008196469.1 1949 3.2e-215 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42958 BP_3 260.29 1.42 9099 189238003 XP_969912.2 3006 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925068|ref|XP_008194156.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925070|ref|XP_008194157.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|270008050|gb|EFA04498.1| hypothetical protein TcasGA2_TC014806 [Tribolium castaneum] 642925074 XM_008195937.1 248 5.69799e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 252 1.5e-19 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF00096//PF13465//PF04988//PF02196//PF00715//PF05792 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//Raf-like Ras-binding domain//Interleukin 2//Candida agglutinin-like (ALS) GO:0007165//GO:0040007//GO:0008283//GO:0006955//GO:0007155 signal transduction//growth//cell proliferation//immune response//cell adhesion GO:0003677//GO:0005057//GO:0008083//GO:0046872//GO:0005134 DNA binding//receptor signaling protein activity//growth factor activity//metal ion binding//interleukin-2 receptor binding GO:0005634//GO:0005576//GO:0005893 nucleus//extracellular region//interleukin-2 receptor complex -- -- Cluster-8309.4296 BP_3 20.58 0.39 2844 642921677 XP_008192920.1 1071 1.2e-113 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 393 2.0e-36 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.42960 BP_3 15.25 0.31 2680 91092368 XP_971937.1 1294 1.6e-139 PREDICTED: dnaJ homolog dnj-5 [Tribolium castaneum] -- -- -- -- -- K09534 DNAJC14 DnaJ homolog subfamily C member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09534 Q921R4 425 3.7e-40 DnaJ homolog subfamily C member 14 OS=Mus musculus GN=Dnajc14 PE=2 SV=2 PF09726//PF05390 Transmembrane protein//Yeast cell wall synthesis protein KRE9/KNH1 GO:0042546//GO:0006078 cell wall biogenesis//(1->6)-beta-D-glucan biosynthetic process -- -- GO:0016021 integral component of membrane KOG0720 Molecular chaperone (DnaJ superfamily) Cluster-8309.42962 BP_3 165.00 3.10 2859 642927489 XP_008195288.1 1569 2.2e-171 PREDICTED: neuropilin and tolloid-like protein 1 [Tribolium castaneum] 642927488 XM_008197066.1 249 4.93683e-125 PREDICTED: Tribolium castaneum neuropilin and tolloid-like protein 1 (LOC658952), mRNA -- -- -- -- Q8NC67 400 3.2e-37 Neuropilin and tolloid-like protein 2 OS=Homo sapiens GN=NETO2 PE=1 SV=1 PF02535//PF00057//PF00430//PF01956 ZIP Zinc transporter//Low-density lipoprotein receptor domain class A//ATP synthase B/B' CF(0)//Integral membrane protein DUF106 GO:0055085//GO:0030001//GO:0015986//GO:0015992 transmembrane transport//metal ion transport//ATP synthesis coupled proton transport//proton transport GO:0005515//GO:0015078//GO:0046873 protein binding//hydrogen ion transmembrane transporter activity//metal ion transmembrane transporter activity GO:0016020//GO:0045263 membrane//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.42963 BP_3 176.23 1.90 4756 728418761 AIY68380.1 1519 2.2e-165 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 709 7.8e-73 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF13499//PF01153//PF13405//PF13833//PF12763//PF08115//PF00036//PF03874//PF00326//PF13202//PF07859 EF-hand domain pair//Glypican//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//SFI toxin family//EF hand//RNA polymerase Rpb4//Prolyl oligopeptidase family//EF hand//alpha/beta hydrolase fold GO:0009405//GO:0006144//GO:0008152//GO:0006351//GO:0006206//GO:0006508 pathogenesis//purine nucleobase metabolic process//metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//proteolysis GO:0003899//GO:0043395//GO:0016787//GO:0008236//GO:0005515//GO:0005509 DNA-directed RNA polymerase activity//heparan sulfate proteoglycan binding//hydrolase activity//serine-type peptidase activity//protein binding//calcium ion binding GO:0005730//GO:0005578//GO:0005576//GO:0016020 nucleolus//proteinaceous extracellular matrix//extracellular region//membrane -- -- Cluster-8309.42964 BP_3 3.18 1.04 439 91091742 XP_966408.1 334 5.3e-29 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 276 1.2e-23 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 -- -- GO:0008152 metabolic process GO:0030170//GO:0008483 pyridoxal phosphate binding//transaminase activity -- -- KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.42967 BP_3 427.62 4.29 5101 642915075 XP_008190400.1 5163 0.0e+00 PREDICTED: unconventional myosin-IXa isoform X1 [Tribolium castaneum]>gi|642915077|ref|XP_008190401.1| PREDICTED: unconventional myosin-IXa isoform X1 [Tribolium castaneum]>gi|270002356|gb|EEZ98803.1| hypothetical protein TcasGA2_TC001372 [Tribolium castaneum] 768442001 XM_011564452.1 512 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q63358 2222 3.0e-248 Unconventional myosin-IXb OS=Rattus norvegicus GN=Myo9b PE=1 SV=1 PF00788//PF00437//PF09280//PF02954//PF15177//PF00612//PF00063 Ras association (RalGDS/AF-6) domain//Type II/IV secretion system protein//XPC-binding domain//Bacterial regulatory protein, Fis family//Interleukin-28A//IQ calmodulin-binding motif//Myosin head (motor domain) GO:0035556//GO:0007165//GO:0006810//GO:0006281//GO:0043161//GO:0006289//GO:0007259//GO:0050778//GO:0051607 intracellular signal transduction//signal transduction//transport//DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair//JAK-STAT cascade//positive regulation of immune response//defense response to virus GO:0005125//GO:0043565//GO:0005524//GO:0003774//GO:0046872//GO:0003684//GO:0005515 cytokine activity//sequence-specific DNA binding//ATP binding//motor activity//metal ion binding//damaged DNA binding//protein binding GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.42968 BP_3 50.54 43.04 342 642912471 XP_008200876.1 298 6.1e-25 PREDICTED: transcription elongation regulator 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 141 4.1e-08 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862//PF06459 DDHD domain//Ryanodine Receptor TM 4-6 GO:0006816//GO:0006874 calcium ion transport//cellular calcium ion homeostasis GO:0005219//GO:0046872 ryanodine-sensitive calcium-release channel activity//metal ion binding GO:0016021//GO:0005622 integral component of membrane//intracellular KOG0155 Transcription factor CA150 Cluster-8309.42969 BP_3 1422.79 39.34 2035 642916336 XP_008190980.1 1473 2.1e-160 PREDICTED: rab11 family-interacting protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12485 RAB11FIP3_4 Rab11 family-interacting protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K12485 Q86YS3 404 7.7e-38 Rab11 family-interacting protein 4 OS=Homo sapiens GN=RAB11FIP4 PE=1 SV=1 PF08653//PF05557 DASH complex subunit Dam1//Mitotic checkpoint protein GO:0008608//GO:0007094 attachment of spindle microtubules to kinetochore//mitotic spindle assembly checkpoint -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG0982 Centrosomal protein Nuf Cluster-8309.42970 BP_3 13.70 0.31 2427 642916336 XP_008190980.1 341 4.5e-29 PREDICTED: rab11 family-interacting protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12485 RAB11FIP3_4 Rab11 family-interacting protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K12485 -- -- -- -- PF07716//PF05531//PF06156 Basic region leucine zipper//Nucleopolyhedrovirus P10 protein//Protein of unknown function (DUF972) GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0019028 transcription factor complex//viral capsid -- -- Cluster-8309.42971 BP_3 920.38 8.93 5257 642930931 XP_008196146.1 2320 3.3e-258 PREDICTED: ephrin type-A receptor 4-B isoform X2 [Tribolium castaneum] 642930930 XM_008197924.1 475 0 PREDICTED: Tribolium castaneum ephrin type-A receptor 4-B (LOC658635), transcript variant X2, mRNA K05110 EPHB1, ELK, NET Eph receptor B1 http://www.genome.jp/dbget-bin/www_bget?ko:K05110 P54755 1396 1.9e-152 Ephrin type-A receptor 5 OS=Gallus gallus GN=EPHA5 PE=2 SV=1 PF07731//PF06293//PF16656//PF00041//PF00069//PF07714//PF00536//PF04587//PF05434//PF07647 Multicopper oxidase//Lipopolysaccharide kinase (Kdo/WaaP) family//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase//SAM domain (Sterile alpha motif)//ADP-specific Phosphofructokinase/Glucokinase conserved region//TMEM9//SAM domain (Sterile alpha motif) GO:0005975//GO:0055114//GO:0006771//GO:0019497//GO:0006468 carbohydrate metabolic process//oxidation-reduction process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0046872//GO:0004672//GO:0003993//GO:0016773//GO:0016491//GO:0005515//GO:0005507//GO:0005524 metal ion binding//protein kinase activity//acid phosphatase activity//phosphotransferase activity, alcohol group as acceptor//oxidoreductase activity//protein binding//copper ion binding//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.42972 BP_3 31.24 0.38 4258 642916336 XP_008190980.1 341 8.0e-29 PREDICTED: rab11 family-interacting protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12485 RAB11FIP3_4 Rab11 family-interacting protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K12485 -- -- -- -- PF09034//PF06156//PF05531//PF07716 TRADD, N-terminal domain//Protein of unknown function (DUF972)//Nucleopolyhedrovirus P10 protein//Basic region leucine zipper GO:0043123//GO:0006260//GO:0006355//GO:0007165 positive regulation of I-kappaB kinase/NF-kappaB signaling//DNA replication//regulation of transcription, DNA-templated//signal transduction GO:0003700//GO:0004871//GO:0043565//GO:0005515 transcription factor activity, sequence-specific DNA binding//signal transducer activity//sequence-specific DNA binding//protein binding GO:0005667//GO:0019028 transcription factor complex//viral capsid -- -- Cluster-8309.42973 BP_3 27.90 1.17 1441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42974 BP_3 33.12 0.31 5494 166998249 NP_001107795.1 2592 9.8e-290 CYCLE [Tribolium castaneum]>gi|140270864|gb|ABO86538.1| CYCLE [Tribolium castaneum] 121945612 AB289690.1 179 7.8083e-86 Dianemobius nigrofasciatus mRNA for circadian transcription modulator CYCLE, partial cds K02296 ARNTL, BMAL1, CYC aryl hydrocarbon receptor nuclear translocator-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02296 A0MLS5 1442 9.1e-158 Aryl hydrocarbon receptor nuclear translocator-like protein 1 OS=Equus caballus GN=ARNTL PE=2 SV=1 PF08447//PF08446//PF00010//PF00989//PF02159 PAS fold//PAS fold//Helix-loop-helix DNA-binding domain//PAS fold//Oestrogen receptor GO:0006355//GO:0043401//GO:0007165 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//signal transduction GO:0003700//GO:0004871//GO:0005496//GO:0030284//GO:0005515//GO:0046983//GO:0003677 transcription factor activity, sequence-specific DNA binding//signal transducer activity//steroid binding//estrogen receptor activity//protein binding//protein dimerization activity//DNA binding GO:0005737//GO:0005667//GO:0005634 cytoplasm//transcription factor complex//nucleus KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.42977 BP_3 448.54 14.38 1795 332374794 AEE62538.1 980 2.7e-103 unknown [Dendroctonus ponderosae]>gi|546674015|gb|ERL85508.1| hypothetical protein D910_02927 [Dendroctonus ponderosae] -- -- -- -- -- K01444 AGA, aspG N4-(beta-N-acetylglucosaminyl)-L-asparaginase http://www.genome.jp/dbget-bin/www_bget?ko:K01444 O02467 840 1.9e-88 N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (Fragment) OS=Spodoptera frugiperda PE=1 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1593 Asparaginase Cluster-8309.42979 BP_3 126.60 17.93 632 478255719 ENN75928.1 637 5.6e-64 hypothetical protein YQE_07465, partial [Dendroctonus ponderosae]>gi|546681163|gb|ERL91307.1| hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35502 169 4.3e-11 Esterase FE4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42980 BP_3 391.91 4.27 4711 270013440 EFA09888.1 842 7.1e-87 hypothetical protein TcasGA2_TC012037 [Tribolium castaneum] -- -- -- -- -- K08497 SEC20 protein transport protein SEC20 http://www.genome.jp/dbget-bin/www_bget?ko:K08497 Q12981 377 2.4e-34 Vesicle transport protein SEC20 OS=Homo sapiens GN=BNIP1 PE=1 SV=3 PF13890//PF03836//PF04513 Rab3 GTPase-activating protein catalytic subunit//RasGAP C-terminus//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007264 small GTPase mediated signal transduction GO:0005096//GO:0005198 GTPase activator activity//structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope -- -- Cluster-8309.42982 BP_3 20.27 0.45 2474 642923462 XP_008193755.1 945 4.2e-99 PREDICTED: forkhead box protein L2-like isoform X1 [Tribolium castaneum] 507561117 XM_004664203.1 146 7.71738e-68 PREDICTED: Jaculus jaculus forkhead box L2 (Foxl2), mRNA K09405 FOXL forkhead box protein L http://www.genome.jp/dbget-bin/www_bget?ko:K09405 O88470 395 1.0e-36 Forkhead box protein L2 OS=Mus musculus GN=Foxl2 PE=1 SV=2 PF00250//PF06070 Forkhead domain//Herpesvirus large structural phosphoprotein UL32 GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0005198 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//structural molecule activity GO:0005667 transcription factor complex -- -- Cluster-8309.42983 BP_3 1545.67 15.66 5049 642924854 XP_008194067.1 5142 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein mahjong [Tribolium castaneum] 662191784 XM_008470499.1 80 7.75206e-31 PREDICTED: Diaphorina citri protein mahjong (LOC103506118), mRNA K11789 VPRBP, DCAF1 HIV-1 Vpr-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11789 Q9Y4B6 2635 3.8e-296 Protein VPRBP OS=Homo sapiens GN=VPRBP PE=1 SV=3 PF08513 LisH -- -- GO:0005515 protein binding -- -- KOG1832 HIV-1 Vpr-binding protein Cluster-8309.42984 BP_3 77.19 0.55 7043 642928264 XP_969418.2 1140 3.0e-121 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q8BQR4 470 6.0e-45 KAT8 regulatory NSL complex subunit 2 OS=Mus musculus GN=Kansl2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.42985 BP_3 219.83 1.11 9864 478250015 ENN70521.1 3990 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 658876389 XM_008422979.1 108 4.13514e-46 PREDICTED: Poecilia reticulata unconventional myosin-Ig-like (LOC103473050), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2850 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF00612//PF00063//PF06414//PF00437//PF06017 IQ calmodulin-binding motif//Myosin head (motor domain)//Zeta toxin//Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding GO:0006810 transport GO:0003774//GO:0016301//GO:0005524//GO:0005515 motor activity//kinase activity//ATP binding//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.42986 BP_3 178.87 1.30 6944 91077500 XP_969314.1 3436 0.0e+00 PREDICTED: exocyst complex component 1 [Tribolium castaneum]>gi|270002145|gb|EEZ98592.1| hypothetical protein TcasGA2_TC001107 [Tribolium castaneum] 805812953 XM_012292417.1 89 1.06023e-35 PREDICTED: Megachile rotundata exocyst complex component 1 (LOC100878684), transcript variant X4, mRNA -- -- -- -- Q9VVG4 2060 2.5e-229 Exocyst complex component 1 OS=Drosophila melanogaster GN=sec3 PE=1 SV=2 PF08446//PF07544//PF00588//PF06009 PAS fold//RNA polymerase II transcription mediator complex subunit 9//SpoU rRNA Methylase family//Laminin Domain II GO:0006396//GO:0006357//GO:0007155//GO:0006355//GO:0009451 RNA processing//regulation of transcription from RNA polymerase II promoter//cell adhesion//regulation of transcription, DNA-templated//RNA modification GO:0008173//GO:0003723//GO:0001104 RNA methyltransferase activity//RNA binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2148 Exocyst protein Sec3 Cluster-8309.42988 BP_3 19.00 0.63 1739 91090820 XP_971545.1 1658 6.3e-182 PREDICTED: heparan sulfate glucosamine 3-O-sulfotransferase 1 [Tribolium castaneum] 198456690 XM_001360374.2 94 4.34879e-39 Drosophila pseudoobscura pseudoobscura GA17321 (Dpse\GA17321), partial mRNA K08104 HS3ST5 http://www.genome.jp/dbget-bin/www_bget?ko:K08104 Q8IZT8 772 1.4e-80 Heparan sulfate glucosamine 3-O-sulfotransferase 5 OS=Homo sapiens GN=HS3ST5 PE=1 SV=1 PF00685//PF03567//PF04947 Sulfotransferase domain//Sulfotransferase family//Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane KOG3704 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase Cluster-8309.42989 BP_3 942.20 15.42 3237 270001944 EEZ98391.1 2260 1.8e-251 hypothetical protein TcasGA2_TC000855 [Tribolium castaneum] 755966655 XM_011307270.1 318 2.46113e-163 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X5, mRNA K12075 DLG2_3 discs large protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12075 P31007 1822 4.6e-202 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF14604//PF00595//PF00018//PF13180 Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.42991 BP_3 1514.32 21.31 3717 189237356 XP_969548.2 2743 2.1e-307 PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|642923199|ref|XP_008193652.1| PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|270007091|gb|EFA03539.1| hypothetical protein TcasGA2_TC013542 [Tribolium castaneum] 817080180 XM_012407117.1 207 1.43342e-101 PREDICTED: Athalia rosae transmembrane 9 superfamily member 2 (LOC105689811), transcript variant X2, mRNA K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q66HG5 2133 4.6e-238 Transmembrane 9 superfamily member 2 OS=Rattus norvegicus GN=Tm9sf2 PE=2 SV=1 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.42992 BP_3 1185.60 16.33 3792 189237356 XP_969548.2 2743 2.1e-307 PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|642923199|ref|XP_008193652.1| PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|270007091|gb|EFA03539.1| hypothetical protein TcasGA2_TC013542 [Tribolium castaneum] 817080180 XM_012407117.1 207 1.46263e-101 PREDICTED: Athalia rosae transmembrane 9 superfamily member 2 (LOC105689811), transcript variant X2, mRNA K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q66HG5 2133 4.7e-238 Transmembrane 9 superfamily member 2 OS=Rattus norvegicus GN=Tm9sf2 PE=2 SV=1 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.42993 BP_3 67.74 0.86 4081 642922153 XP_008193036.1 4275 0.0e+00 PREDICTED: afadin isoform X1 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 Q9QZQ1 1399 6.5e-153 Afadin OS=Mus musculus GN=Mllt4 PE=1 SV=3 PF16011//PF00595//PF00498//PF13180 Carbohydrate-binding family 9//PDZ domain (Also known as DHR or GLGF)//FHA domain//PDZ domain GO:0005975//GO:0016052 carbohydrate metabolic process//carbohydrate catabolic process GO:0030246//GO:0004553//GO:0005515 carbohydrate binding//hydrolase activity, hydrolyzing O-glycosyl compounds//protein binding -- -- KOG1892 Actin filament-binding protein Afadin Cluster-8309.42994 BP_3 2.00 11.84 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42995 BP_3 125.00 1.09 5807 817087169 XP_012266348.1 531 1.0e-50 PREDICTED: CUGBP Elav-like family member 2 isoform X2 [Athalia rosae] 194861276 XM_001969711.1 74 1.93176e-27 Drosophila erecta GG23780 (Dere\GG23780), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q5R8Y8 377 3.0e-34 CUGBP Elav-like family member 2 OS=Pongo abelii GN=CELF2 PE=2 SV=2 PF00076//PF15320//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//mRNA cap methylation, RNMT-activating mini protein//RNA recognition motif GO:0032259 methylation GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0005845 mRNA cap binding complex KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.42998 BP_3 93.54 0.93 5152 642917797 XP_008191290.1 2204 9.0e-245 PREDICTED: NAD-dependent histone deacetylase Sir2 [Tribolium castaneum]>gi|270003357|gb|EEZ99804.1| hypothetical protein TcasGA2_TC002584 [Tribolium castaneum] -- -- -- -- -- K11411 SIRT1, SIR2L1 NAD-dependent deacetylase sirtuin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11411 Q9VK34 1115 7.0e-120 NAD-dependent histone deacetylase Sir2 OS=Drosophila melanogaster GN=Sir2 PE=1 SV=1 PF00205//PF04574//PF02146 Thiamine pyrophosphate enzyme, central domain//Protein of unknown function (DUF592)//Sir2 family GO:0006807//GO:0006355//GO:0006342//GO:0006476 nitrogen compound metabolic process//regulation of transcription, DNA-templated//chromatin silencing//protein deacetylation GO:0030976//GO:0000287//GO:0008270//GO:0051287//GO:0070403//GO:0017136//GO:0016811 thiamine pyrophosphate binding//magnesium ion binding//zinc ion binding//NAD binding//NAD+ binding//NAD-dependent histone deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0000118 histone deacetylase complex KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family) Cluster-8309.42999 BP_3 1470.47 30.14 2643 546685535 ERL95022.1 492 1.5e-46 hypothetical protein D910_12292 [Dendroctonus ponderosae] 449102215 JX081307.1 150 4.93149e-70 Pleurobrachia bachei dynein light chain-2 mRNA, complete cds K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q78P75 465 8.5e-45 Dynein light chain 2, cytoplasmic OS=Rattus norvegicus GN=Dynll2 PE=1 SV=1 PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.43001 BP_3 1450.62 17.04 4395 91091728 XP_967315.1 1628 4.8e-178 PREDICTED: argininosuccinate synthase [Tribolium castaneum]>gi|270001069|gb|EEZ97516.1| hypothetical protein TcasGA2_TC011361 [Tribolium castaneum] 78496741 CP000153.1 36 1.94165e-06 Sulfurimonas denitrificans DSM 1251, complete genome K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 Q0IFL5 1380 1.1e-150 Argininosuccinate synthase OS=Aedes aegypti GN=AAEL004701 PE=3 SV=1 PF00764//PF00498 Arginosuccinate synthase//FHA domain GO:0006531//GO:0006560//GO:0006526//GO:0006522 aspartate metabolic process//proline metabolic process//arginine biosynthetic process//alanine metabolic process GO:0004055//GO:0005515//GO:0005524 argininosuccinate synthase activity//protein binding//ATP binding -- -- KOG1706 Argininosuccinate synthase Cluster-8309.43002 BP_3 442.54 4.41 5130 642922159 XP_008193039.1 2620 5.2e-293 PREDICTED: nostrin isoform X1 [Tribolium castaneum]>gi|270007234|gb|EFA03682.1| hypothetical protein TcasGA2_TC013784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6WKZ7 419 3.6e-39 Nostrin OS=Mus musculus GN=Nostrin PE=1 SV=2 PF02402//PF14604//PF00018//PF02185//PF06466 Lysis protein//Variant SH3 domain//SH3 domain//Hr1 repeat//PCAF (P300/CBP-associated factor) N-terminal domain GO:0006355//GO:0007165//GO:0009405//GO:0019835//GO:0042967 regulation of transcription, DNA-templated//signal transduction//pathogenesis//cytolysis//acyl-carrier-protein biosynthetic process GO:0004402//GO:0005515 histone acetyltransferase activity//protein binding GO:0000123//GO:0005634//GO:0019867 histone acetyltransferase complex//nucleus//outer membrane KOG4429 Uncharacterized conserved protein, contains SH3 and FCH domains Cluster-8309.43004 BP_3 18.00 1.73 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43005 BP_3 629.26 5.28 6036 91086459 XP_969641.1 1106 2.2e-117 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Tribolium castaneum] -- -- -- -- -- K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 P57093 721 4.0e-74 Phytanoyl-CoA dioxygenase, peroxisomal OS=Rattus norvegicus GN=Phyh PE=1 SV=2 PF12326 N-glycosylation protein GO:0034599 cellular response to oxidative stress -- -- GO:0005789 endoplasmic reticulum membrane KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.43007 BP_3 95.76 3.86 1486 91089625 XP_973443.1 909 3.8e-95 PREDICTED: tudor and KH domain-containing protein [Tribolium castaneum]>gi|270012611|gb|EFA09059.1| hypothetical protein TcasGA2_TC006774 [Tribolium castaneum] -- -- -- -- -- K18406 TDRKH, TDRD2 tudor domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18406 Q80VL1 431 4.2e-41 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 -- -- -- -- GO:0003723 RNA binding -- -- KOG2039 Transcriptional coactivator p100 Cluster-8309.4301 BP_3 1.00 0.43 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43010 BP_3 20.17 0.39 2770 546682290 ERL92248.1 263 5.7e-20 hypothetical protein D910_09565 [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 192 4.0e-13 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382//PF06662 RTX N-terminal domain//D-glucuronyl C5-epimerase C-terminus GO:0006024//GO:0009405 glycosaminoglycan biosynthetic process//pathogenesis GO:0016857//GO:0005509 racemase and epimerase activity, acting on carbohydrates and derivatives//calcium ion binding GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.43011 BP_3 95.51 0.61 7860 642910887 XP_008193450.1 4311 0.0e+00 PREDICTED: calcium-dependent secretion activator isoform X5 [Tribolium castaneum] 642910886 XM_008195228.1 1198 0 PREDICTED: Tribolium castaneum calcium-dependent secretion activator (LOC660877), transcript variant X6, mRNA -- -- -- -- Q9NHE5 3654 0.0e+00 Calcium-dependent secretion activator OS=Drosophila melanogaster GN=Caps PE=1 SV=3 PF11615 Protein of unknown function (DUF3249) GO:0000266 mitochondrial fission -- -- GO:0005739 mitochondrion KOG3543 Ca2+-dependent activator protein Cluster-8309.43014 BP_3 13.20 1.54 705 642913083 XP_008201383.1 736 2.1e-75 PREDICTED: disks large 1 tumor suppressor protein isoform X7 [Tribolium castaneum] 642913082 XM_008203161.1 259 3.24163e-131 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X7, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 321 1.1e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.43016 BP_3 300.02 7.62 2189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43020 BP_3 1378.29 30.40 2477 270003943 EFA00391.1 1322 8.2e-143 hypothetical protein TcasGA2_TC003237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULV3 169 1.7e-10 Cip1-interacting zinc finger protein OS=Homo sapiens GN=CIZ1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43023 BP_3 10.00 4.28 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43025 BP_3 244.00 6.64 2063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43027 BP_3 5.07 1.63 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.43028 BP_3 7034.00 69.67 5158 91094043 XP_968570.1 5338 0.0e+00 PREDICTED: peroxidasin [Tribolium castaneum]>gi|270004795|gb|EFA01243.1| peroxidasin [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q9VZZ4 3408 0.0e+00 Peroxidasin OS=Drosophila melanogaster GN=Pxn PE=1 SV=1 PF13895//PF07354//PF02480//PF13855//PF09728 Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Alphaherpesvirus glycoprotein E//Leucine rich repeat//Myosin-like coiled-coil protein GO:0007339//GO:0006804//GO:0006979//GO:0055114 binding of sperm to zona pellucida//obsolete peroxidase reaction//response to oxidative stress//oxidation-reduction process GO:0019905//GO:0005515//GO:0004601//GO:0020037 syntaxin binding//protein binding//peroxidase activity//heme binding GO:0005576//GO:0016020 extracellular region//membrane KOG2408 Peroxidase/oxygenase Cluster-8309.43031 BP_3 207.98 3.38 3257 157130405 XP_001655700.1 449 1.8e-41 AAEL002600-PA [Aedes aegypti]>gi|108881960|gb|EAT46185.1| AAEL002600-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- P27435 282 1.7e-23 Tryptase OS=Rattus norvegicus GN=Tpsab1 PE=1 SV=2 PF16048//PF11057//PF00089 Frog antimicrobial peptide//Cortexin of kidney//Trypsin GO:0006508//GO:0006952 proteolysis//defense response GO:0004252 serine-type endopeptidase activity GO:0005576//GO:0031224 extracellular region//intrinsic component of membrane -- -- Cluster-8309.43035 BP_3 371.42 3.04 6181 642923131 XP_008193622.1 2730 1.1e-305 PREDICTED: nuclear receptor coactivator 3 isoform X1 [Tribolium castaneum] 642923146 XM_008195408.1 411 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.2e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF00989//PF00010//PF08447 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- -- -- Cluster-8309.43036 BP_3 812.76 6.88 5989 642923131 XP_008193622.1 2730 1.1e-305 PREDICTED: nuclear receptor coactivator 3 isoform X1 [Tribolium castaneum] 642923146 XM_008195408.1 411 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.1e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.43037 BP_3 1484.72 18.56 4147 642926286 XP_008194862.1 2720 1.1e-304 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like [Tribolium castaneum] 642926285 XM_008196640.1 270 1.52352e-136 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1584 2.3e-174 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF00069//PF01392//PF07714 Protein kinase domain//Fz domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.43038 BP_3 45.91 0.31 7513 642939202 XP_008200380.1 3478 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 168 1.39291e-79 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1288 8.9e-140 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF01825//PF02793//PF02140//PF02617//PF00002//PF03547 GPCR proteolysis site, GPS, motif//Hormone receptor domain//Galactose binding lectin domain//ATP-dependent Clp protease adaptor protein ClpS//7 transmembrane receptor (Secretin family)//Membrane transport protein GO:0030163//GO:0055085//GO:0007186 protein catabolic process//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0030246 G-protein coupled receptor activity//carbohydrate binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.43039 BP_3 16.93 0.34 2721 478263397 ENN81769.1 801 2.3e-82 hypothetical protein YQE_01862, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26474 246 2.2e-19 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF16656//PF13895//PF15491//PF00041//PF01108 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//CST, telomere maintenance, complex subunit CTC1//Fibronectin type III domain//Tissue factor GO:0019497//GO:0006771//GO:0000723 hexachlorocyclohexane metabolic process//riboflavin metabolic process//telomere maintenance GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity -- -- KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.43040 BP_3 744.93 4.98 7499 642922218 XP_008193066.1 916 3.0e-95 PREDICTED: TBC1 domain family member 24 isoform X3 [Tribolium castaneum] 768435492 XM_011560896.1 107 1.12933e-45 PREDICTED: Plutella xylostella TBC1 domain family member 24 (LOC105389728), transcript variant X5, mRNA -- -- -- -- Q9ULP9 328 1.9e-28 TBC1 domain family member 24 OS=Homo sapiens GN=TBC1D24 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.43042 BP_3 99.60 0.66 7544 642922218 XP_008193066.1 916 3.0e-95 PREDICTED: TBC1 domain family member 24 isoform X3 [Tribolium castaneum] 768435492 XM_011560896.1 107 1.13614e-45 PREDICTED: Plutella xylostella TBC1 domain family member 24 (LOC105389728), transcript variant X5, mRNA -- -- -- -- Q9ULP9 328 1.9e-28 TBC1 domain family member 24 OS=Homo sapiens GN=TBC1D24 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.43043 BP_3 10.41 0.33 1803 91095059 XP_972457.1 767 1.3e-78 PREDICTED: uroporphyrinogen decarboxylase [Tribolium castaneum] -- -- -- -- -- K01599 hemE, UROD uroporphyrinogen decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01599 Q9V595 590 1.9e-59 Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=3 SV=1 PF01208 Uroporphyrinogen decarboxylase (URO-D) GO:0015994//GO:0006779 chlorophyll metabolic process//porphyrin-containing compound biosynthetic process GO:0004853 uroporphyrinogen decarboxylase activity -- -- KOG2872 Uroporphyrinogen decarboxylase Cluster-8309.43044 BP_3 309.27 4.51 3598 91078392 XP_974372.1 1555 1.1e-169 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270003986|gb|EFA00434.1| hypothetical protein TcasGA2_TC003288 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 594 1.3e-59 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.43045 BP_3 1.00 45.97 208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08911 NUP50 (Nucleoporin 50 kDa) -- -- -- -- GO:0005643 nuclear pore -- -- Cluster-8309.43050 BP_3 162.78 6.08 1583 91091790 XP_970226.1 1209 6.6e-130 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X1 [Tribolium castaneum] 512883118 XM_002943445.2 41 1.14606e-09 PREDICTED: Xenopus (Silurana) tropicalis mannosidase, alpha, class 1A, member 2 (man1a2), mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 636 7.5e-65 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.43051 BP_3 50.14 0.41 6239 282721016 NP_001164208.1 2490 7.5e-278 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 409 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 9.4e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF12937//PF01557//PF00646//PF12125//PF00400//PF15324 F-box-like//Fumarylacetoacetate (FAA) hydrolase family//F-box domain//D domain of beta-TrCP//WD domain, G-beta repeat//Hedgehog signalling target GO:0007224//GO:0008152 smoothened signaling pathway//metabolic process GO:0003824//GO:0046983//GO:0005515 catalytic activity//protein dimerization activity//protein binding -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.43052 BP_3 636.30 5.28 6100 282721016 NP_001164208.1 2490 7.3e-278 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 9.2e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF01557//PF12937//PF15324//PF00646//PF12125//PF00400 Fumarylacetoacetate (FAA) hydrolase family//F-box-like//Hedgehog signalling target//F-box domain//D domain of beta-TrCP//WD domain, G-beta repeat GO:0007224//GO:0008152 smoothened signaling pathway//metabolic process GO:0003824//GO:0005515//GO:0046983 catalytic activity//protein binding//protein dimerization activity -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.43053 BP_3 48.35 0.61 4103 91088055 XP_967186.1 1358 9.1e-147 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 94 1.03762e-38 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q2NL29 1146 1.4e-123 Inositol-3-phosphate synthase 1 OS=Bos taurus GN=ISYNA1 PE=2 SV=1 PF13912//PF07994//PF13762 C2H2-type zinc finger//Myo-inositol-1-phosphate synthase//Mitochondrial splicing apparatus component GO:0006021//GO:0000372//GO:0019872//GO:0008654 inositol biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//phospholipid biosynthetic process GO:0004512//GO:0046872//GO:0000166 inositol-3-phosphate synthase activity//metal ion binding//nucleotide binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.43054 BP_3 430.00 4.19 5237 642934874 XP_008197845.1 2625 1.4e-293 PREDICTED: ecdysone-induced protein 75B, isoforms C/D isoform X4 [Tribolium castaneum] 443682249 KC020244.1 254 1.51126e-127 Monochamus alternatus ecdysone-induced protein 75-like protein (E75) mRNA, partial cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1308 3.0e-142 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4846 Nuclear receptor Cluster-8309.43057 BP_3 180.25 5.69 1818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43058 BP_3 211.26 1.05 10003 642922153 XP_008193036.1 5647 0.0e+00 PREDICTED: afadin isoform X1 [Tribolium castaneum] 462316425 APGK01045079.1 64 1.20797e-21 Dendroctonus ponderosae Seq01045089, whole genome shotgun sequence K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 P55196 2099 1.1e-233 Afadin OS=Homo sapiens GN=MLLT4 PE=1 SV=3 PF16011//PF08272//PF00595//PF05745//PF00498//PF00788//PF11808//PF02096//PF13180 Carbohydrate-binding family 9//Topoisomerase I zinc-ribbon-like//PDZ domain (Also known as DHR or GLGF)//Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)//FHA domain//Ras association (RalGDS/AF-6) domain//Domain of unknown function (DUF3329)//60Kd inner membrane protein//PDZ domain GO:0016052//GO:0016310//GO:0005975//GO:0006265//GO:0007165//GO:0051205 carbohydrate catabolic process//phosphorylation//carbohydrate metabolic process//DNA topological change//signal transduction//protein insertion into membrane GO:0003918//GO:0003677//GO:0005515//GO:0030246//GO:0004673//GO:0004553 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding//protein binding//carbohydrate binding//protein histidine kinase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005694//GO:0019867//GO:0009365//GO:0016021 chromosome//outer membrane//protein histidine kinase complex//integral component of membrane KOG1892 Actin filament-binding protein Afadin Cluster-8309.43062 BP_3 911.50 52.35 1131 91078844 XP_971675.1 520 3.7e-50 PREDICTED: leucine-rich repeat-containing protein 59 [Tribolium castaneum]>gi|270003717|gb|EFA00165.1| hypothetical protein TcasGA2_TC002987 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9X4 323 1.1e-28 Leucine-rich repeat-containing protein 59 OS=Bos taurus GN=LRRC59 PE=2 SV=1 PF03985//PF03040//PF00560//PF11744//PF01956//PF04998//PF13855 Paf1//CemA family//Leucine Rich Repeat//Aluminium activated malate transporter//Integral membrane protein DUF106//RNA polymerase Rpb1, domain 5//Leucine rich repeat GO:0006351//GO:0006368//GO:0006144//GO:0015743//GO:0016570//GO:0006206 transcription, DNA-templated//transcription elongation from RNA polymerase II promoter//purine nucleobase metabolic process//malate transport//histone modification//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005515 DNA binding//DNA-directed RNA polymerase activity//protein binding GO:0016593//GO:0016021//GO:0016020//GO:0005730 Cdc73/Paf1 complex//integral component of membrane//membrane//nucleolus KOG0619 FOG: Leucine rich repeat Cluster-8309.43063 BP_3 49.08 0.77 3350 189238741 XP_972079.2 3193 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927110|ref|XP_008195141.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927112|ref|XP_008195142.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927115|ref|XP_008195143.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum] 699256288 XM_009863644.1 39 3.17283e-08 PREDICTED: Ciona intestinalis ubiquitin carboxyl-terminal hydrolase 20-like (LOC100184024), mRNA K11848 USP20_33 ubiquitin carboxyl-terminal hydrolase 20/33 http://www.genome.jp/dbget-bin/www_bget?ko:K11848 A0JM59 1233 9.5e-134 Ubiquitin carboxyl-terminal hydrolase 20 OS=Xenopus tropicalis GN=usp20 PE=2 SV=1 PF02148//PF17001//PF06337//PF00443 Zn-finger in ubiquitin-hydrolases and other protein//Type III secretion basal body protein I, YscI, HrpB, PscI//DUSP domain//Ubiquitin carboxyl-terminal hydrolase GO:0006508//GO:0016579//GO:0009306 proteolysis//protein deubiquitination//protein secretion GO:0004843//GO:0036459//GO:0008270 ubiquitin-specific protease activity//ubiquitinyl hydrolase activity//zinc ion binding -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.43065 BP_3 33.36 0.50 3519 91094647 XP_971886.1 927 7.4e-97 PREDICTED: protein transport protein Sec24C [Tribolium castaneum]>gi|270016466|gb|EFA12912.1| hypothetical protein TcasGA2_TC006982 [Tribolium castaneum] 751205538 XM_011178054.1 47 1.19089e-12 PREDICTED: Solenopsis invicta protein transport protein Sec24C (LOC105208248), mRNA K14007 SEC24 protein transport protein SEC24 http://www.genome.jp/dbget-bin/www_bget?ko:K14007 P53992 588 6.2e-59 Protein transport protein Sec24C OS=Homo sapiens GN=SEC24C PE=1 SV=3 PF04815 Sec23/Sec24 helical domain GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1984 Vesicle coat complex COPII, subunit SFB3 Cluster-8309.43066 BP_3 71.89 0.83 4488 642914155 XP_008201569.1 5162 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X3 [Tribolium castaneum]>gi|270001582|gb|EEZ98029.1| hypothetical protein TcasGA2_TC000430 [Tribolium castaneum] -- -- -- -- -- K04426 MAP3K5, ASK1 mitogen-activated protein kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04426 Q6ZN16 2571 9.0e-289 Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens GN=MAP3K15 PE=1 SV=2 PF00069//PF07714//PF07647 Protein kinase domain//Protein tyrosine kinase//SAM domain (Sterile alpha motif) GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005515//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//protein binding//ATP binding -- -- KOG4279 Serine/threonine protein kinase Cluster-8309.43067 BP_3 515.17 7.65 3536 270014368 EFA10816.1 549 5.0e-53 hypothetical protein TcasGA2_TC030657 [Tribolium castaneum] -- -- -- -- -- K18588 COQ10 coenzyme Q-binding protein COQ10 http://www.genome.jp/dbget-bin/www_bget?ko:K18588 Q6DFA6 389 7.4e-36 Coenzyme Q-binding protein COQ10 homolog A, mitochondrial OS=Xenopus laevis GN=coq10b-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3177 Oligoketide cyclase/lipid transport protein Cluster-8309.43068 BP_3 26.10 0.56 2520 642924308 XP_008194241.1 2512 8.5e-281 PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X3 [Tribolium castaneum]>gi|270007868|gb|EFA04316.1| hypothetical protein TcasGA2_TC014609 [Tribolium castaneum] -- -- -- -- -- K00111 glpA, glpD glycerol-3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00111 A6QLU1 1965 9.4e-219 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Bos taurus GN=GPD2 PE=2 SV=1 PF01266//PF07992//PF01134//PF12831 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Glucose inhibited division protein A//FAD dependent oxidoreductase GO:0006072//GO:0055114//GO:0046486//GO:0008033//GO:0006118 glycerol-3-phosphate metabolic process//oxidation-reduction process//glycerolipid metabolic process//tRNA processing//obsolete electron transport GO:0016491//GO:0004368//GO:0005509//GO:0050660 oxidoreductase activity//glycerol-3-phosphate dehydrogenase activity//calcium ion binding//flavin adenine dinucleotide binding GO:0009331 glycerol-3-phosphate dehydrogenase complex KOG0042 Glycerol-3-phosphate dehydrogenase Cluster-8309.43069 BP_3 603.93 10.96 2947 91083661 XP_975782.1 3160 0.0e+00 PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K00111 glpA, glpD glycerol-3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00111 A6QLU1 2200 6.2e-246 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Bos taurus GN=GPD2 PE=2 SV=1 PF07992//PF00036//PF12831//PF01266//PF13499//PF13833//PF13405//PF01134 Pyridine nucleotide-disulphide oxidoreductase//EF hand//FAD dependent oxidoreductase//FAD dependent oxidoreductase//EF-hand domain pair//EF-hand domain pair//EF-hand domain//Glucose inhibited division protein A GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0016491//GO:0005509//GO:0050660 oxidoreductase activity//calcium ion binding//flavin adenine dinucleotide binding -- -- KOG0042 Glycerol-3-phosphate dehydrogenase Cluster-8309.43070 BP_3 29.83 0.31 4914 478251175 ENN71651.1 1464 5.5e-159 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 Q9P2N4 774 2.3e-80 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.43073 BP_3 214.23 3.80 3012 642919036 XP_008191706.1 1793 2.4e-197 PREDICTED: uncharacterized protein LOC663686 isoform X2 [Tribolium castaneum] 749755207 XM_011141773.1 86 2.12604e-34 PREDICTED: Harpegnathos saltator uncharacterized LOC105183546 (LOC105183546), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43075 BP_3 1158.03 24.66 2555 270001418 EEZ97865.1 1466 1.7e-159 hypothetical protein TcasGA2_TC000237 [Tribolium castaneum] 642914800 XM_008192137.1 546 0 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X3, mRNA K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 P57721 735 4.0e-76 Poly(rC)-binding protein 3 OS=Homo sapiens GN=PCBP3 PE=2 SV=2 PF00013//PF06326//PF13014//PF13184//PF07650 KH domain//Vesiculovirus matrix protein//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723//GO:0005198 RNA binding//structural molecule activity GO:0019031 viral envelope KOG2190 PolyC-binding proteins alphaCP-1 and related KH domain proteins Cluster-8309.43076 BP_3 1619.00 22.07 3827 -- -- -- -- -- 642914805 XM_008192139.1 52 2.15371e-15 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF06990 Galactose-3-O-sulfotransferase GO:0009058//GO:0006687 biosynthetic process//glycosphingolipid metabolic process GO:0001733 galactosylceramide sulfotransferase activity GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane -- -- Cluster-8309.43077 BP_3 292.81 8.44 1964 642931096 XP_974337.3 729 3.7e-74 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWU1 501 4.2e-49 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.43078 BP_3 66.37 0.46 7291 91082383 XP_968748.1 2378 8.5e-265 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.15359e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1618 4.7e-178 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF00005//PF03193//PF01637//PF06414//PF00437//PF02224//PF00664//PF01926//PF13304 NB-ARC domain//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Zeta toxin//Type II/IV secretion system protein//Cytidylate kinase//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006206//GO:0055085//GO:0006810//GO:0006139 pyrimidine nucleobase metabolic process//transmembrane transport//transport//nucleobase-containing compound metabolic process GO:0016301//GO:0016887//GO:0004127//GO:0005525//GO:0017111//GO:0042626//GO:0005524//GO:0003924//GO:0043531 kinase activity//ATPase activity//cytidylate kinase activity//GTP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//ADP binding GO:0016021 integral component of membrane -- -- Cluster-8309.4308 BP_3 3.00 0.59 537 642924239 XP_008194212.1 469 1.4e-44 PREDICTED: neuroligin-1 [Tribolium castaneum] 642924238 XM_008195990.1 161 7.30312e-77 PREDICTED: Tribolium castaneum neuroligin 2 (LOC663865), mRNA -- -- -- -- Q5XG92 140 8.3e-08 Carboxylesterase 4A OS=Homo sapiens GN=CES4A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.43081 BP_3 99.25 0.90 5619 332376995 AEE63637.1 1603 4.8e-175 unknown [Dendroctonus ponderosae]>gi|478252044|gb|ENN72475.1| hypothetical protein YQE_10817, partial [Dendroctonus ponderosae] 768439449 XM_011563053.1 264 4.47869e-133 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K04712 DEGS sphingolipid delta-4 desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K04712 Q3ZBY7 1091 4.7e-117 Sphingolipid delta(4)-desaturase DES1 OS=Bos taurus GN=DEGS1 PE=2 SV=1 PF00487//PF00769//PF01233 Fatty acid desaturase//Ezrin/radixin/moesin family//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0004379//GO:0008092 glycylpeptide N-tetradecanoyltransferase activity//cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane KOG2987 Fatty acid desaturase Cluster-8309.43083 BP_3 3.00 0.38 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43085 BP_3 94.60 3.25 1693 91089543 XP_971483.1 801 1.4e-82 PREDICTED: uncharacterized protein LOC660130 isoform X1 [Tribolium castaneum] 642933375 XM_966390.2 173 5.136e-83 PREDICTED: Tribolium castaneum uncharacterized LOC660130 (LOC660130), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF00822//PF00335//PF13903//PF06687 PMP-22/EMP/MP20/Claudin family//Tetraspanin family//PMP-22/EMP/MP20/Claudin tight junction//SUR7/PalI family -- -- -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.43087 BP_3 732.19 16.21 2469 642932818 XP_008196998.1 3141 0.0e+00 PREDICTED: protein CLEC16A isoform X6 [Tribolium castaneum] -- -- -- -- -- K19513 CLEC16A protein CLEC16A http://www.genome.jp/dbget-bin/www_bget?ko:K19513 Q2KHT3 1236 3.1e-134 Protein CLEC16A OS=Homo sapiens GN=CLEC16A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2219 Uncharacterized conserved protein Cluster-8309.43088 BP_3 347.94 2.46 7105 478254018 ENN74310.1 6594 0.0e+00 hypothetical protein YQE_09281, partial [Dendroctonus ponderosae] 242005974 XM_002423790.1 223 3.50928e-110 Pediculus humanus corporis jumonji/arid domain-containing protein, putative, mRNA K11446 KDM5, JARID1 histone demethylase JARID1 http://www.genome.jp/dbget-bin/www_bget?ko:K11446 Q9VMJ7 3561 0.0e+00 Lysine-specific demethylase lid OS=Drosophila melanogaster GN=lid PE=1 SV=1 PF00628//PF01388//PF08429 PHD-finger//ARID/BRIGHT DNA binding domain//PLU-1-like protein GO:0055114 oxidation-reduction process GO:0016706//GO:0003677//GO:0005515 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//DNA binding//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.43090 BP_3 159.73 3.15 2732 478259045 ENN78988.1 1984 1.6e-219 hypothetical protein YQE_04539, partial [Dendroctonus ponderosae] 640815149 XM_008066140.1 74 9.02446e-28 PREDICTED: Tarsius syrichta peroxisomal biogenesis factor 6 (PEX6), transcript variant X2, mRNA K13339 PEX6, PXAAA1 peroxin-6 http://www.genome.jp/dbget-bin/www_bget?ko:K13339 Q99LC9 1138 8.0e-123 Peroxisome assembly factor 2 OS=Mus musculus GN=Pex6 PE=2 SV=1 PF14532//PF01695//PF07728//PF05496//PF01057//PF06068//PF00158//PF00004//PF07724//PF07726//PF02562//PF02367//PF00910 Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Parvovirus non-structural protein NS1//TIP49 C-terminus//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase GO:0019079//GO:0006281//GO:0002949//GO:0006355//GO:0006310 viral genome replication//DNA repair//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA recombination GO:0005524//GO:0003678//GO:0003723//GO:0008134//GO:0016887//GO:0009378//GO:0003724 ATP binding//DNA helicase activity//RNA binding//transcription factor binding//ATPase activity//four-way junction helicase activity//RNA helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain Cluster-8309.43091 BP_3 9.72 0.37 1551 91089983 XP_974005.1 1394 2.3e-151 PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934014|ref|XP_008197604.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934016|ref|XP_008197605.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|270013684|gb|EFA10132.1| hypothetical protein TcasGA2_TC012312 [Tribolium castaneum] -- -- -- -- -- K15779 PGM2 phosphoglucomutase / phosphopentomutase http://www.genome.jp/dbget-bin/www_bget?ko:K15779 Q5RFI8 953 1.3e-101 Phosphoglucomutase-2 OS=Pongo abelii GN=PGM2 PE=2 SV=3 PF02879//PF02878//PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III GO:0005975 carbohydrate metabolic process GO:0016868//GO:0000287 intramolecular transferase activity, phosphotransferases//magnesium ion binding -- -- KOG1220 Phosphoglucomutase/phosphomannomutase Cluster-8309.43093 BP_3 8.00 2.03 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43096 BP_3 780.50 3.70 10447 642914280 XP_008201619.1 1367 2.1e-147 PREDICTED: cyclic AMP-dependent transcription factor ATF-6 beta [Tribolium castaneum] 332375533 BT127946.1 81 4.47442e-31 Dendroctonus ponderosae clone DPO1025_H21 unknown mRNA K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q6GM78 703 8.5e-72 Isoaspartyl peptidase/L-asparaginase OS=Xenopus laevis GN=asrgl1 PE=2 SV=1 PF01112//PF16622//PF13465//PF03453//PF04977//PF04275//PF14861//PF07776//PF01166//PF03131//PF13912//PF12356//PF07716//PF06156//PF00096//PF00170//PF06005 Asparaginase//zinc-finger C2H2-type//Zinc-finger double domain//MoeA N-terminal region (domain I and II)//Septum formation initiator//Phosphomevalonate kinase//Plant antimicrobial peptide//Zinc-finger associated domain (zf-AD)//TSC-22/dip/bun family//bZIP Maf transcription factor//C2H2-type zinc finger//Protein of unknown function (DUF3643)//Basic region leucine zipper//Protein of unknown function (DUF972)//Zinc finger, C2H2 type//bZIP transcription factor//Protein of unknown function (DUF904) GO:0032465//GO:0050832//GO:0006915//GO:0007049//GO:0006694//GO:0006260//GO:0006355//GO:0016567//GO:0032324//GO:0000917//GO:0043093//GO:0006695 regulation of cytokinesis//defense response to fungus//apoptotic process//cell cycle//steroid biosynthetic process//DNA replication//regulation of transcription, DNA-templated//protein ubiquitination//molybdopterin cofactor biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis//cholesterol biosynthetic process GO:0016787//GO:0003700//GO:0004631//GO:0043565//GO:0008270//GO:0004842//GO:0003677//GO:0046872 hydrolase activity//transcription factor activity, sequence-specific DNA binding//phosphomevalonate kinase activity//sequence-specific DNA binding//zinc ion binding//ubiquitin-protein transferase activity//DNA binding//metal ion binding GO:0005737//GO:0005667//GO:0005634 cytoplasm//transcription factor complex//nucleus KOG1592 Asparaginase Cluster-8309.43097 BP_3 1866.13 29.26 3366 642913378 XP_008195461.1 2341 7.7e-261 PREDICTED: uncharacterized protein LOC657396 isoform X2 [Tribolium castaneum]>gi|270002028|gb|EEZ98475.1| hypothetical protein TcasGA2_TC000967 [Tribolium castaneum] 195480065 XM_002101088.1 119 1.07593e-52 Drosophila yakuba GE15793 (Dyak\GE15793), partial mRNA -- -- -- -- -- -- -- -- PF01853//PF01048 MOZ/SAS family//Phosphorylase superfamily GO:0009116//GO:0006355 nucleoside metabolic process//regulation of transcription, DNA-templated GO:0003824//GO:0016747 catalytic activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.43098 BP_3 50.59 0.34 7380 642920318 XP_008192297.1 1522 1.6e-165 PREDICTED: uncharacterized protein LOC664527 isoform X1 [Tribolium castaneum] 642920319 XM_008194076.1 157 1.78235e-73 PREDICTED: Tribolium castaneum uncharacterized LOC664527 (LOC664527), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00646//PF01429//PF13855//PF12937 F-box domain//Methyl-CpG binding domain//Leucine rich repeat//F-box-like -- -- GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.431 BP_3 4.00 0.31 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43101 BP_3 9.00 4.10 396 194354011 NP_001123895.1 405 2.8e-37 cytochrome P450 CYP9Z1 [Tribolium castaneum]>gi|270012791|gb|EFA09239.1| cytochrome P450 9Z1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 306 3.5e-27 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0046872//GO:0016705 heme binding//oxidoreductase activity//iron ion binding//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.43103 BP_3 1145.24 41.68 1616 189236728 XP_974937.2 906 9.2e-95 PREDICTED: ATP-dependent (S)-NAD(P)H-hydrate dehydratase [Tribolium castaneum] -- -- -- -- -- K17757 CARKD ATP-dependent NAD(P)H-hydrate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K17757 E3XDZ8 662 7.4e-68 ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Anopheles darlingi GN=AND_21715 PE=3 SV=1 PF01256 Carbohydrate kinase -- -- GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity -- -- KOG3974 Predicted sugar kinase Cluster-8309.43104 BP_3 740.00 23.85 1787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04514 Bluetongue virus non-structural protein NS2 -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.43105 BP_3 1077.71 12.62 4407 642928504 XP_008193818.1 3415 0.0e+00 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VGW4 1340 4.9e-146 Endoplasmic reticulum metallopeptidase 1 OS=Xenopus laevis GN=ermp1 PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.43106 BP_3 1.00 13.75 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43107 BP_3 2.00 0.71 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43109 BP_3 287.03 4.01 3745 642921365 XP_972788.2 3354 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 1.94937e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1220 3.4e-132 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF13639//PF12678//PF12861//PF00787//PF00097 Ring finger domain//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//PX domain//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0035091//GO:0005515//GO:0046872//GO:0004842//GO:0008270 phosphatidylinositol binding//protein binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.4311 BP_3 1.57 0.33 522 642911511 XP_008199453.1 276 3.3e-22 PREDICTED: protein unc-79 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43110 BP_3 138.85 4.47 1788 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43112 BP_3 9.05 0.40 1385 817220587 XP_012285889.1 407 5.7e-37 PREDICTED: ankyrin-1-like isoform X1 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43114 BP_3 56.35 0.73 4032 642924664 XP_008194387.1 1401 9.2e-152 PREDICTED: tensin isoform X13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43115 BP_3 34.07 0.51 3498 270001943 EEZ98390.1 619 3.8e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 1.31983e-116 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 1.6e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.43117 BP_3 75.03 0.82 4701 642919877 XP_008192107.1 3215 0.0e+00 PREDICTED: N-acetyltransferase 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14521 NAT10, KRE33 N-acetyltransferase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14521 Q8K224 2729 4.5e-307 N-acetyltransferase 10 OS=Mus musculus GN=Nat10 PE=2 SV=1 PF00583//PF13508//PF13718 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//GNAT acetyltransferase 2 GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG2036 Predicted P-loop ATPase fused to an acetyltransferase Cluster-8309.43119 BP_3 99.59 7.04 974 546678053 ERL88777.1 630 5.6e-63 hypothetical protein D910_06159 [Dendroctonus ponderosae] -- -- -- -- -- K01934 MTHFS 5-formyltetrahydrofolate cyclo-ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01934 Q9D110 447 3.8e-43 5-formyltetrahydrofolate cyclo-ligase OS=Mus musculus GN=Mthfs PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3093 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.43120 BP_3 72.82 2.52 1684 546684777 ERL94372.1 764 2.8e-78 hypothetical protein D910_11652 [Dendroctonus ponderosae] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q9UG56 516 6.6e-51 Phosphatidylserine decarboxylase proenzyme OS=Homo sapiens GN=PISD PE=2 SV=4 PF02666 Phosphatidylserine decarboxylase GO:0006544//GO:0046486//GO:0008654//GO:0006566//GO:0006563 glycine metabolic process//glycerolipid metabolic process//phospholipid biosynthetic process//threonine metabolic process//L-serine metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.43121 BP_3 914.54 13.96 3450 642913416 XP_008201002.1 2426 1.1e-270 PREDICTED: supernumerary limbs isoform X2 [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 5.2e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF12937//PF15324//PF00400//PF12125//PF00646 F-box-like//Hedgehog signalling target//WD domain, G-beta repeat//D domain of beta-TrCP//F-box domain GO:0007224 smoothened signaling pathway GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.43122 BP_3 1233.56 10.80 5795 642925926 XP_008194700.1 6572 0.0e+00 PREDICTED: tetratricopeptide repeat protein 28 [Tribolium castaneum] 347968281 XM_312278.5 861 0 Anopheles gambiae str. PEST AGAP002648-PA (AgaP_AGAP002648) mRNA, complete cds -- -- -- -- Q96AY4 4208 0.0e+00 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 PF13414//PF13176//PF00515//PF13374//PF10255//PF13181//PF07721//PF10579 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//RNA polymerase I-associated factor PAF67//Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region GO:0007268//GO:0006446 synaptic transmission//regulation of translational initiation GO:0043495//GO:0005515//GO:0042802//GO:0033130//GO:0003743 protein anchor//protein binding//identical protein binding//acetylcholine receptor binding//translation initiation factor activity GO:0005852//GO:0005737//GO:0005840 eukaryotic translation initiation factor 3 complex//cytoplasm//ribosome KOG0548 Molecular co-chaperone STI1 Cluster-8309.43123 BP_3 60.91 0.84 3783 189237356 XP_969548.2 2710 1.4e-303 PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|642923199|ref|XP_008193652.1| PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|270007091|gb|EFA03539.1| hypothetical protein TcasGA2_TC013542 [Tribolium castaneum] 817080180 XM_012407117.1 207 1.45912e-101 PREDICTED: Athalia rosae transmembrane 9 superfamily member 2 (LOC105689811), transcript variant X2, mRNA K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q66HG5 2100 3.1e-234 Transmembrane 9 superfamily member 2 OS=Rattus norvegicus GN=Tm9sf2 PE=2 SV=1 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.43128 BP_3 2.00 0.79 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43129 BP_3 1667.36 31.90 2811 332376452 AEE63366.1 839 9.4e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08360 CYB561 cytochrome b-561 http://www.genome.jp/dbget-bin/www_bget?ko:K08360 P34465 448 8.5e-43 Putative cytochrome b561 OS=Caenorhabditis elegans GN=F55H2.5 PE=3 SV=1 PF03188//PF03124//PF01292 Eukaryotic cytochrome b561//EXS family//Prokaryotic cytochrome b561 GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane KOG1619 Cytochrome b Cluster-8309.4313 BP_3 15.00 0.58 1533 662195961 XP_008470989.1 142 3.4e-06 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09153//PF09258 Domain of unknown function (DUF1938)//Glycosyl transferase family 64 domain GO:0006024//GO:0015012 glycosaminoglycan biosynthetic process//heparan sulfate proteoglycan biosynthetic process -- -- GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.43131 BP_3 1153.70 17.62 3448 478253971 ENN74263.1 1931 2.7e-213 hypothetical protein YQE_09235, partial [Dendroctonus ponderosae] -- -- -- -- -- K08189 SLC16A13 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08189 Q7RTY0 334 1.7e-29 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF05924//PF00473//PF07690 SAMP Motif//Corticotropin-releasing factor family//Major Facilitator Superfamily GO:0055085//GO:0016055//GO:0007165 transmembrane transport//Wnt signaling pathway//signal transduction GO:0005179//GO:0008013 hormone activity//beta-catenin binding GO:0016021//GO:0016342//GO:0005576 integral component of membrane//catenin complex//extracellular region KOG2504 Monocarboxylate transporter Cluster-8309.43132 BP_3 56.90 0.48 6055 642935990 XP_008198259.1 3666 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1110 3.1e-119 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.43133 BP_3 14.45 0.31 2574 91094331 XP_966352.1 2228 7.4e-248 PREDICTED: ubiquitin-like modifier-activating enzyme 1 [Tribolium castaneum] 817198774 XM_012419622.1 50 1.8665e-14 PREDICTED: Orussus abietinus ubiquitin-like modifier-activating enzyme 1 (LOC105696846), mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 Q29504 1577 9.4e-174 Ubiquitin-like modifier-activating enzyme 1 OS=Oryctolagus cuniculus GN=UBA1 PE=2 SV=1 PF13241//PF00070//PF01006//PF00899 Putative NAD(P)-binding//Pyridine nucleotide-disulphide oxidoreductase//Hepatitis C virus non-structural protein NS4a//ThiF family GO:0055114//GO:0006779//GO:0019354//GO:0016032 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//viral process GO:0008641//GO:0043115//GO:0016491 small protein activating enzyme activity//precorrin-2 dehydrogenase activity//oxidoreductase activity GO:0019012 virion KOG2012 Ubiquitin activating enzyme UBA1 Cluster-8309.43135 BP_3 413.46 2.52 8204 642932579 XP_008196910.1 4293 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 201 6.88203e-98 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1947 3.7e-216 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF00443//PF00569//PF08496//PF02723//PF12678//PF02148//PF14634//PF17122//PF00097//PF01165//PF00637//PF13639//PF09726//PF12861 Ubiquitin carboxyl-terminal hydrolase//Zinc finger, ZZ type//Peptidase family S49 N-terminal//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//zinc-RING finger domain//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//Ribosomal protein S21//Region in Clathrin and VPS//Ring finger domain//Transmembrane protein//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0006412//GO:0016567//GO:0006886//GO:0016192//GO:0016579//GO:0042254 translation//protein ubiquitination//intracellular protein transport//vesicle-mediated transport//protein deubiquitination//ribosome biogenesis GO:0005515//GO:0004842//GO:0046872//GO:0036459//GO:0004252//GO:0003735//GO:0008270 protein binding//ubiquitin-protein transferase activity//metal ion binding//ubiquitinyl hydrolase activity//serine-type endopeptidase activity//structural constituent of ribosome//zinc ion binding GO:0005680//GO:0005886//GO:0016020//GO:0016021//GO:0005840 anaphase-promoting complex//plasma membrane//membrane//integral component of membrane//ribosome KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.43136 BP_3 160.96 0.98 8215 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 177 1.51296e-84 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF09726//PF12861//PF00637//PF01165//PF13639//PF05680//PF00097//PF17122//PF02148//PF02723//PF12678//PF14634//PF08496//PF00443//PF00569 Transmembrane protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Region in Clathrin and VPS//Ribosomal protein S21//Ring finger domain//ATP synthase E chain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//Zn-finger in ubiquitin-hydrolases and other protein//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//zinc-RING finger domain//Peptidase family S49 N-terminal//Ubiquitin carboxyl-terminal hydrolase//Zinc finger, ZZ type GO:0015992//GO:0042254//GO:0016579//GO:0016192//GO:0006886//GO:0015986//GO:0016567//GO:0006412 proton transport//ribosome biogenesis//protein deubiquitination//vesicle-mediated transport//intracellular protein transport//ATP synthesis coupled proton transport//protein ubiquitination//translation GO:0008270//GO:0003735//GO:0015078//GO:0004252//GO:0036459//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//structural constituent of ribosome//hydrogen ion transmembrane transporter activity//serine-type endopeptidase activity//ubiquitinyl hydrolase activity//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005840//GO:0016021//GO:0000276//GO:0016020//GO:0005886//GO:0005680 ribosome//integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//membrane//plasma membrane//anaphase-promoting complex KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.43139 BP_3 410.79 1.95 10469 270003689 EFA00137.1 2104 7.2e-233 hypothetical protein TcasGA2_TC002957 [Tribolium castaneum] 642916224 XM_008192715.1 305 1.35126e-155 PREDICTED: Tribolium castaneum uncharacterized LOC662985 (LOC662985), mRNA -- -- -- -- Q9V5L3 506 5.9e-49 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067//PF00631//PF02459//PF00439 Cytochrome P450//GGL domain//Adenoviral DNA terminal protein//Bromodomain GO:0006260//GO:0007186//GO:0055114//GO:0007165 DNA replication//G-protein coupled receptor signaling pathway//oxidation-reduction process//signal transduction GO:0004871//GO:0005506//GO:0020037//GO:0003677//GO:0016705//GO:0005515 signal transducer activity//iron ion binding//heme binding//DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//protein binding GO:0005834 heterotrimeric G-protein complex KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.43140 BP_3 458.71 2.36 9659 642937913 XP_972695.3 1638 7.3e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.2e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43142 BP_3 1094.53 14.85 3845 91076698 XP_971949.1 3939 0.0e+00 PREDICTED: dipeptidyl peptidase 9 [Tribolium castaneum] -- -- -- -- -- K08656 DPP9 dipeptidyl-peptidase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08656 Q86TI2 1788 4.8e-198 Dipeptidyl peptidase 9 OS=Homo sapiens GN=DPP9 PE=1 SV=3 PF00326//PF07859//PF02230//PF13954//PF02129//PF01738//PF00930 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//PapC N-terminal domain//X-Pro dipeptidyl-peptidase (S15 family)//Dienelactone hydrolase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236//GO:0005515 hydrolase activity//serine-type peptidase activity//protein binding -- -- KOG2281 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Cluster-8309.43143 BP_3 211.33 3.59 3127 91076698 XP_971949.1 3595 0.0e+00 PREDICTED: dipeptidyl peptidase 9 [Tribolium castaneum] -- -- -- -- -- K08656 DPP9 dipeptidyl-peptidase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08656 Q86TI2 1540 2.2e-169 Dipeptidyl peptidase 9 OS=Homo sapiens GN=DPP9 PE=1 SV=3 PF05577//PF07859//PF00326//PF13954//PF02129//PF00930 Serine carboxypeptidase S28//alpha/beta hydrolase fold//Prolyl oligopeptidase family//PapC N-terminal domain//X-Pro dipeptidyl-peptidase (S15 family)//Dipeptidyl peptidase IV (DPP IV) N-terminal region GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0005515//GO:0008236 hydrolase activity//protein binding//serine-type peptidase activity -- -- KOG2281 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Cluster-8309.43144 BP_3 722.93 15.40 2555 91088613 XP_973949.1 1834 3.6e-202 PREDICTED: pseudouridylate synthase 7 homolog [Tribolium castaneum]>gi|270011693|gb|EFA08141.1| hypothetical protein TcasGA2_TC005758 [Tribolium castaneum] -- -- -- -- -- K06176 truD, PUS7 tRNA pseudouridine13 synthase http://www.genome.jp/dbget-bin/www_bget?ko:K06176 Q96PZ0 995 2.9e-106 Pseudouridylate synthase 7 homolog OS=Homo sapiens GN=PUS7 PE=1 SV=2 PF01142 tRNA pseudouridine synthase D (TruD) GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG2339 Uncharacterized conserved protein Cluster-8309.43145 BP_3 231.45 2.47 4816 330371797 AEC12819.1 1380 3.0e-149 lactate dehydrogenase [Litopenaeus vannamei]>gi|385211791|gb|AFI47930.1| L-lactate dehydrogenase isoform 2 [Litopenaeus vannamei] 262401152 FJ774758.1 534 0 Scylla paramamosain l-lactate dehydrogenase mRNA, partial cds K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 1178 3.3e-127 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF02056//PF00056//PF02866 Family 4 glycosyl hydrolase//lactate/malate dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114//GO:0005975//GO:0006094//GO:0044262//GO:0006534//GO:0006096 oxidation-reduction process//carbohydrate metabolic process//gluconeogenesis//cellular carbohydrate metabolic process//cysteine metabolic process//glycolytic process GO:0000166//GO:0016616//GO:0016491//GO:0004553//GO:0004459 nucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//L-lactate dehydrogenase activity GO:0005737 cytoplasm KOG1495 Lactate dehydrogenase Cluster-8309.43146 BP_3 612.31 24.77 1483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43149 BP_3 641.70 3.39 9421 91083997 XP_975257.1 1901 2.3e-209 PREDICTED: phosphatidate cytidylyltransferase, photoreceptor-specific [Tribolium castaneum]>gi|270007993|gb|EFA04441.1| hypothetical protein TcasGA2_TC014743 [Tribolium castaneum] 729297249 XM_010548190.1 40 2.49717e-08 PREDICTED: Tarenaya hassleriana phosphatidate cytidylyltransferase (LOC104818548), transcript variant X5, mRNA K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 1615 1.4e-177 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 PF13639//PF05485//PF14604//PF00018//PF12906//PF12678 Ring finger domain//THAP domain//Variant SH3 domain//SH3 domain//RING-variant domain//RING-H2 zinc finger GO:0016024//GO:0008654//GO:0046486 CDP-diacylglycerol biosynthetic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0008270//GO:0003676//GO:0004605//GO:0005515 zinc ion binding//nucleic acid binding//phosphatidate cytidylyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1440 CDP-diacylglycerol synthase Cluster-8309.43150 BP_3 197.80 0.96 10205 91083997 XP_975257.1 1901 2.4e-209 PREDICTED: phosphatidate cytidylyltransferase, photoreceptor-specific [Tribolium castaneum]>gi|270007993|gb|EFA04441.1| hypothetical protein TcasGA2_TC014743 [Tribolium castaneum] 729297249 XM_010548190.1 40 2.7058e-08 PREDICTED: Tarenaya hassleriana phosphatidate cytidylyltransferase (LOC104818548), transcript variant X5, mRNA K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 1615 1.5e-177 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 PF05485//PF12906 THAP domain//RING-variant domain GO:0046486//GO:0008654//GO:0016024 glycerolipid metabolic process//phospholipid biosynthetic process//CDP-diacylglycerol biosynthetic process GO:0008270//GO:0004605//GO:0003676 zinc ion binding//phosphatidate cytidylyltransferase activity//nucleic acid binding GO:0016021 integral component of membrane KOG1440 CDP-diacylglycerol synthase Cluster-8309.43152 BP_3 19.54 0.69 1663 91084991 XP_972796.1 990 1.7e-104 PREDICTED: serine palmitoyltransferase 1 [Tribolium castaneum]>gi|270009012|gb|EFA05460.1| hypothetical protein TcasGA2_TC015642 [Tribolium castaneum] -- -- -- -- -- K00654 SPT serine palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00654 Q3MHG1 579 3.2e-58 Serine palmitoyltransferase 1 OS=Bos taurus GN=SPTLC1 PE=2 SV=1 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1358 Serine palmitoyltransferase Cluster-8309.43153 BP_3 417.71 6.85 3231 642915218 XP_008190526.1 2071 1.5e-229 PREDICTED: UDP-glucose 6-dehydrogenase isoform X1 [Tribolium castaneum] 332376888 BT128627.1 168 5.9547e-80 Dendroctonus ponderosae clone DPO012_D10 unknown mRNA K00012 UGDH, ugd UDPglucose 6-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00012 O02373 1908 4.9e-212 UDP-glucose 6-dehydrogenase OS=Drosophila melanogaster GN=sgl PE=1 SV=1 PF00984//PF02892//PF03446//PF03721//PF03720 UDP-glucose/GDP-mannose dehydrogenase family, central domain//BED zinc finger//NAD binding domain of 6-phosphogluconate dehydrogenase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain GO:0055114//GO:0006098//GO:0019521 oxidation-reduction process//pentose-phosphate shunt//D-gluconate metabolic process GO:0051287//GO:0016616//GO:0004616//GO:0003677 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//DNA binding -- -- KOG2666 UDP-glucose/GDP-mannose dehydrogenase Cluster-8309.43154 BP_3 187.68 3.42 2934 91094931 XP_970563.1 2741 2.8e-307 PREDICTED: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase [Tribolium castaneum]>gi|270016688|gb|EFA13134.1| hypothetical protein TcasGA2_TC010318 [Tribolium castaneum] 572264375 XM_006610309.1 75 2.69714e-28 PREDICTED: Apis dorsata bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2-like (LOC102670740), transcript variant X2, mRNA K13811 PAPSS 3'-phosphoadenosine 5'-phosphosulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13811 Q27128 2136 1.6e-238 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase OS=Urechis caupo PE=2 SV=1 PF01747//PF01583 ATP-sulfurylase//Adenylylsulphate kinase GO:0006144//GO:0000103//GO:0006790 purine nucleobase metabolic process//sulfate assimilation//sulfur compound metabolic process GO:0004020//GO:0005524//GO:0004781 adenylylsulfate kinase activity//ATP binding//sulfate adenylyltransferase (ATP) activity -- -- KOG4238 Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase Cluster-8309.43155 BP_3 1229.70 41.88 1707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04449//PF03153 CS1 type fimbrial major subunit//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672//GO:0009289 transcription factor TFIIA complex//pilus -- -- Cluster-8309.43156 BP_3 212.28 3.71 3047 646682520 KDR02319.1 1568 3.0e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 3.54888e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.4e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF07714//PF00937//PF00069 Protein tyrosine kinase//Coronavirus nucleocapsid protein//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.43159 BP_3 139.85 1.56 4618 642912496 XP_008200890.1 1792 4.8e-197 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LUQ4 218 6.5e-16 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.43161 BP_3 1.00 0.92 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43163 BP_3 77.00 2.70 1664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01436//PF02723 NHL repeat//Non-structural protein NS3/Small envelope protein E -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.43164 BP_3 47.97 2.14 1370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43168 BP_3 255.94 2.17 5972 478251857 ENN72296.1 1149 2.3e-122 hypothetical protein YQE_11039, partial [Dendroctonus ponderosae]>gi|546673558|gb|ERL85133.1| hypothetical protein D910_02555 [Dendroctonus ponderosae] -- -- -- -- -- K01834 PGAM, gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01834 Q5ZLN1 818 2.2e-85 Phosphoglycerate mutase 1 OS=Gallus gallus GN=PGAM1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0235 Phosphoglycerate mutase Cluster-8309.43170 BP_3 285.59 8.23 1964 546676100 ERL87167.1 1897 1.4e-209 hypothetical protein D910_04567 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H267 422 6.1e-40 Vacuolar protein sorting-associated protein 33B OS=Homo sapiens GN=VPS33B PE=1 SV=2 PF08926//PF00995 Domain of unknown function (DUF1908)//Sec1 family GO:0016192//GO:0016310//GO:0006904//GO:0009069//GO:0006468 vesicle-mediated transport//phosphorylation//vesicle docking involved in exocytosis//serine family amino acid metabolic process//protein phosphorylation GO:0000287//GO:0004674//GO:0005524 magnesium ion binding//protein serine/threonine kinase activity//ATP binding -- -- KOG1302 Vacuolar sorting protein VPS33/slp1 (Sec1 family) Cluster-8309.43174 BP_3 316.95 2.18 7284 332376224 AEE63252.1 1345 5.2e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 Q9Y4P3 750 2.1e-77 Transducin beta-like protein 2 OS=Homo sapiens GN=TBL2 PE=1 SV=1 PF00930//PF01612//PF00400 Dipeptidyl peptidase IV (DPP IV) N-terminal region//3'-5' exonuclease//WD domain, G-beta repeat GO:0006508//GO:0006139 proteolysis//nucleobase-containing compound metabolic process GO:0008408//GO:0003676//GO:0005515 3'-5' exonuclease activity//nucleic acid binding//protein binding -- -- KOG2248 3'-5' exonuclease Cluster-8309.43175 BP_3 97.29 0.71 6859 332376224 AEE63252.1 1345 4.9e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 Q9Y4P3 750 2.0e-77 Transducin beta-like protein 2 OS=Homo sapiens GN=TBL2 PE=1 SV=1 PF00400//PF00930//PF01612 WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//3'-5' exonuclease GO:0006508//GO:0006139 proteolysis//nucleobase-containing compound metabolic process GO:0008408//GO:0003676//GO:0005515 3'-5' exonuclease activity//nucleic acid binding//protein binding -- -- KOG2248 3'-5' exonuclease Cluster-8309.43176 BP_3 1403.73 9.51 7409 332376224 AEE63252.1 1345 5.3e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 Q9Y4P3 750 2.1e-77 Transducin beta-like protein 2 OS=Homo sapiens GN=TBL2 PE=1 SV=1 PF00400//PF00930//PF01612 WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//3'-5' exonuclease GO:0006139//GO:0006508 nucleobase-containing compound metabolic process//proteolysis GO:0005515//GO:0003676//GO:0008408 protein binding//nucleic acid binding//3'-5' exonuclease activity -- -- KOG2248 3'-5' exonuclease Cluster-8309.43177 BP_3 18.45 0.50 2087 546679672 ERL90099.1 1723 2.2e-189 hypothetical protein D910_07453 [Dendroctonus ponderosae] -- -- -- -- -- K12367 DOCK2 dedicator of cytokinesis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12367 Q8C3J5 1112 6.3e-120 Dedicator of cytokinesis protein 2 OS=Mus musculus GN=Dock2 PE=1 SV=3 PF01524 Geminivirus V1 protein GO:0019048//GO:0060967 modulation by virus of host morphology or physiology//negative regulation of gene silencing by RNA -- -- GO:0030430 host cell cytoplasm KOG1998 Signaling protein DOCK180 Cluster-8309.43179 BP_3 612.85 6.60 4769 642913355 XP_008195386.1 1300 5.6e-140 PREDICTED: protein polybromo-1 [Tribolium castaneum] -- -- -- -- -- K10738 MCM9 DNA helicase MCM9 http://www.genome.jp/dbget-bin/www_bget?ko:K10738 I0IUP4 1075 2.8e-115 DNA helicase MCM9 OS=Gallus gallus GN=MCM9 PE=1 SV=2 PF08073//PF10660//PF00493//PF07728//PF07726 CHDNT (NUC034) domain//Iron-containing outer mitochondrial membrane protein N-terminus//MCM2/3/5 family//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0008270//GO:0016887//GO:0016818//GO:0005524//GO:0051537//GO:0003677 zinc ion binding//ATPase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//2 iron, 2 sulfur cluster binding//DNA binding GO:0043231//GO:0005634 intracellular membrane-bounded organelle//nucleus KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.43180 BP_3 315.91 8.49 2086 91080451 XP_969541.1 2760 1.2e-309 PREDICTED: mediator of RNA polymerase II transcription subunit 17 isoform X1 [Tribolium castaneum]>gi|270005569|gb|EFA02017.1| hypothetical protein TcasGA2_TC007640 [Tribolium castaneum] -- -- -- -- -- K15133 MED17 mediator of RNA polymerase II transcription subunit 17 http://www.genome.jp/dbget-bin/www_bget?ko:K15133 Q7PVZ2 2062 4.4e-230 Mediator of RNA polymerase II transcription subunit 17 OS=Anopheles gambiae GN=MED17 PE=3 SV=2 PF04810//PF10156 Sec23/Sec24 zinc finger//Subunit 17 of Mediator complex GO:0006888//GO:0006886//GO:0006357 ER to Golgi vesicle-mediated transport//intracellular protein transport//regulation of transcription from RNA polymerase II promoter GO:0008270//GO:0001104 zinc ion binding//RNA polymerase II transcription cofactor activity GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.43181 BP_3 111.09 2.90 2140 91080451 XP_969541.1 2731 2.9e-306 PREDICTED: mediator of RNA polymerase II transcription subunit 17 isoform X1 [Tribolium castaneum]>gi|270005569|gb|EFA02017.1| hypothetical protein TcasGA2_TC007640 [Tribolium castaneum] -- -- -- -- -- K15133 MED17 mediator of RNA polymerase II transcription subunit 17 http://www.genome.jp/dbget-bin/www_bget?ko:K15133 Q7PVZ2 2034 8.0e-227 Mediator of RNA polymerase II transcription subunit 17 OS=Anopheles gambiae GN=MED17 PE=3 SV=2 PF04810//PF10156 Sec23/Sec24 zinc finger//Subunit 17 of Mediator complex GO:0006357//GO:0006886//GO:0006888 regulation of transcription from RNA polymerase II promoter//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0001104//GO:0008270 RNA polymerase II transcription cofactor activity//zinc ion binding GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.43182 BP_3 11.68 0.98 864 642910330 XP_970349.3 606 3.0e-60 PREDICTED: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGE0 325 4.8e-29 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Xenopus tropicalis GN=ogfod3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43187 BP_3 232.40 10.12 1399 642922190 XP_008193053.1 1123 5.5e-120 PREDICTED: patronin isoform X1 [Tribolium castaneum] 642922199 XM_008194837.1 290 3.85402e-148 PREDICTED: Tribolium castaneum patronin (LOC660656), transcript variant X6, mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 656 3.2e-67 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex KOG3654 Uncharacterized CH domain protein Cluster-8309.43188 BP_3 497.28 7.69 3409 642922204 XP_008193061.1 936 6.5e-98 PREDICTED: patronin isoform X8 [Tribolium castaneum] 642922199 XM_008194837.1 79 1.876e-30 PREDICTED: Tribolium castaneum patronin (LOC660656), transcript variant X6, mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 656 7.8e-67 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex KOG3654 Uncharacterized CH domain protein Cluster-8309.43190 BP_3 1.54 0.37 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43191 BP_3 25.53 0.52 2679 270000732 EEZ97179.1 525 2.3e-50 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] 642937909 XM_008202132.1 89 4.0583e-36 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 368 1.5e-33 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.43196 BP_3 2.00 1.15 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43202 BP_3 1171.00 11.36 5259 642927507 XP_008195297.1 7776 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642927506 XM_008197075.1 1528 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC661648), mRNA K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9VS29 3232 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05955//PF05790//PF00041//PF13895//PF16656 Equine herpesvirus glycoprotein gp2//Immunoglobulin C2-set domain//Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0007155//GO:0019497//GO:0016032 riboflavin metabolic process//cell adhesion//hexachlorocyclohexane metabolic process//viral process GO:0046872//GO:0003993//GO:0005515 metal ion binding//acid phosphatase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.43205 BP_3 1515.00 18.03 4341 91092762 XP_973584.1 4786 0.0e+00 PREDICTED: isoleucine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270014792|gb|EFA11240.1| hypothetical protein TcasGA2_TC010772 [Tribolium castaneum] -- -- -- -- -- K01870 IARS, ileS isoleucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01870 Q8BU30 3651 0.0e+00 Isoleucine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Iars PE=2 SV=2 PF00133//PF09334//PF04083//PF08264 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Partial alpha/beta-hydrolase lipase region//Anticodon-binding domain of tRNA GO:0006450//GO:0009099//GO:0006418//GO:0006629//GO:0006428//GO:0009098//GO:0009097 regulation of translational fidelity//valine biosynthetic process//tRNA aminoacylation for protein translation//lipid metabolic process//isoleucyl-tRNA aminoacylation//leucine biosynthetic process//isoleucine biosynthetic process GO:0004822//GO:0004812//GO:0002161//GO:0000166//GO:0005524 isoleucine-tRNA ligase activity//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity//nucleotide binding//ATP binding GO:0005737 cytoplasm KOG0434 Isoleucyl-tRNA synthetase Cluster-8309.43206 BP_3 15.59 0.93 1102 91082797 XP_967743.1 398 5.1e-36 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q9D3B1 264 7.2e-22 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Mus musculus GN=Hacd2 PE=2 SV=1 PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.43207 BP_3 103.20 1.68 3249 642927459 XP_968905.2 708 1.7e-71 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q28719 453 2.6e-43 Prostaglandin reductase 1 OS=Oryctolagus cuniculus GN=PTGR1 PE=2 SV=1 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.43208 BP_3 1171.03 11.50 5200 91093137 XP_969665.1 2367 1.1e-263 PREDICTED: breast cancer anti-estrogen resistance protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16832 NEDD9, HEF1, CASL enhancer of filamentation 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16832 Q61140 506 2.9e-49 Breast cancer anti-estrogen resistance protein 1 OS=Mus musculus GN=Bcar1 PE=1 SV=2 PF09726//PF14604//PF00018//PF01282 Transmembrane protein//Variant SH3 domain//SH3 domain//Ribosomal protein S24e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0016021//GO:0005840 intracellular//integral component of membrane//ribosome -- -- Cluster-8309.43209 BP_3 12.00 19.81 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43210 BP_3 649.23 8.55 3950 642928027 XP_008200126.1 3078 0.0e+00 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.71215e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q60902 1260 8.3e-137 Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus GN=Eps15l1 PE=1 SV=3 PF04111//PF00435//PF13833//PF13405//PF13499//PF12763//PF01920//PF10174//PF10186//PF00036//PF03836//PF02601//PF13202//PF00769 Autophagy protein Apg6//Spectrin repeat//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//Prefoldin subunit//RIM-binding protein of the cytomatrix active zone//Vacuolar sorting 38 and autophagy-related subunit 14//EF hand//RasGAP C-terminus//Exonuclease VII, large subunit//EF hand//Ezrin/radixin/moesin family GO:0006308//GO:0007264//GO:0006457//GO:0010508//GO:0006914 DNA catabolic process//small GTPase mediated signal transduction//protein folding//positive regulation of autophagy//autophagy GO:0005509//GO:0008092//GO:0005515//GO:0008855//GO:0051082//GO:0005096 calcium ion binding//cytoskeletal protein binding//protein binding//exodeoxyribonuclease VII activity//unfolded protein binding//GTPase activator activity GO:0048786//GO:0009318//GO:0016272//GO:0005737//GO:0019898 presynaptic active zone//exodeoxyribonuclease VII complex//prefoldin complex//cytoplasm//extrinsic component of membrane KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.43212 BP_3 15.02 0.54 1642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43214 BP_3 183.88 2.60 3694 642932194 XP_008196896.1 1658 1.3e-181 PREDICTED: transcription factor hamlet-like [Tribolium castaneum] 667674288 AE014134.6 89 5.61683e-36 Drosophila melanogaster chromosome 2L K04462 EVI1 ecotropic virus integration site 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04462 Q8I7Z8 890 6.2e-94 Transcription factor hamlet OS=Drosophila melanogaster GN=ham PE=2 SV=1 PF16622//PF13912//PF02892//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.43218 BP_3 227.04 5.30 2355 91088839 XP_970745.1 1131 1.1e-120 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] 642932363 XM_965652.3 358 0 PREDICTED: Tribolium castaneum RNA-binding protein lark (LOC659335), mRNA K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q94901 845 6.5e-89 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF00098//PF08777//PF08675//PF00076//PF16367 Zinc knuckle//RNA binding motif//RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0008270//GO:0000166//GO:0004535//GO:0003676//GO:0046872//GO:0003723 zinc ion binding//nucleotide binding//poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-8309.4322 BP_3 26.00 3.92 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43220 BP_3 72.00 1.38 2812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43221 BP_3 54.65 1.86 1705 189239625 XP_970060.2 1057 3.0e-112 PREDICTED: general transcription factor IIE subunit 2 [Tribolium castaneum]>gi|270009449|gb|EFA05897.1| hypothetical protein TcasGA2_TC008709 [Tribolium castaneum] 820846169 XM_003692874.2 143 2.45847e-66 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K03137 TFIIE2, GTF2E2, TFA2 transcription initiation factor TFIIE subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03137 P29540 601 9.3e-61 General transcription factor IIE subunit 2 OS=Xenopus laevis GN=gtf2e2 PE=2 SV=1 PF09494//PF02186 Slx4 endonuclease//TFIIE beta subunit core domain GO:0006308//GO:0006367//GO:0006260//GO:0006281 DNA catabolic process//transcription initiation from RNA polymerase II promoter//DNA replication//DNA repair GO:0017108 5'-flap endonuclease activity GO:0033557//GO:0005673//GO:0005634 Slx1-Slx4 complex//transcription factor TFIIE complex//nucleus KOG3095 Transcription initiation factor IIE, beta subunit Cluster-8309.43223 BP_3 1134.93 8.15 7007 642924136 XP_008194022.1 7907 0.0e+00 PREDICTED: neural-cadherin isoform X6 [Tribolium castaneum] 642924135 XM_008195800.1 1710 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X6, mRNA -- -- -- -- O15943 7157 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF00672//PF00028//PF01049//PF00008//PF11857 HAMP domain//Cadherin domain//Cadherin cytoplasmic region//EGF-like domain//Domain of unknown function (DUF3377) GO:0007165//GO:0007156 signal transduction//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0004871//GO:0005515//GO:0004222 calcium ion binding//signal transducer activity//protein binding//metalloendopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.43224 BP_3 100.20 1.90 2837 642930353 XP_008196361.1 542 2.6e-52 PREDICTED: protein 4.1 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 375 2.5e-34 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3527 Erythrocyte membrane protein 4.1 and related proteins of the ERM family Cluster-8309.43229 BP_3 256.12 14.76 1128 642920003 XP_008192163.1 1125 2.6e-120 PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum]>gi|642920005|ref|XP_008192164.1| PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K16059 STIM1 stromal interaction molecule 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16059 P83094 775 4.1e-81 Stromal interaction molecule homolog OS=Drosophila melanogaster GN=Stim PE=1 SV=1 PF07647//PF03462//PF00536//PF01576//PF06810//PF02203//PF07851//PF15291//PF05478//PF08702//PF10473//PF07926//PF05384 SAM domain (Sterile alpha motif)//PCRF domain//SAM domain (Sterile alpha motif)//Myosin tail//Phage minor structural protein GP20//Tar ligand binding domain homologue//TMPIT-like protein//Dermcidin, antibiotic peptide//Prominin//Fibrinogen alpha/beta chain family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//Sensor protein DegS GO:0051258//GO:0031640//GO:0007165//GO:0006415//GO:0006606//GO:0006935//GO:0006449//GO:0030168 protein polymerization//killing of cells of other organism//signal transduction//translational termination//protein import into nucleus//chemotaxis//regulation of translational termination//platelet activation GO:0008134//GO:0045502//GO:0005198//GO:0008233//GO:0005102//GO:0016301//GO:0005515//GO:0016149//GO:0004888//GO:0003774//GO:0030674//GO:0042803 transcription factor binding//dynein binding//structural molecule activity//peptidase activity//receptor binding//kinase activity//protein binding//translation release factor activity, codon specific//transmembrane signaling receptor activity//motor activity//protein binding, bridging//protein homodimerization activity GO:0016459//GO:0016021//GO:0005577//GO:0005737//GO:0018444//GO:0005840//GO:0005667//GO:0030286//GO:0016020//GO:0005576 myosin complex//integral component of membrane//fibrinogen complex//cytoplasm//translation release factor complex//ribosome//transcription factor complex//dynein complex//membrane//extracellular region KOG4403 Cell surface glycoprotein STIM, contains SAM domain Cluster-8309.4323 BP_3 50.00 2.41 1293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43231 BP_3 10.28 0.78 930 270000792 EEZ97239.1 463 1.2e-43 hypothetical protein TcasGA2_TC011037 [Tribolium castaneum] -- -- -- -- -- K15156 MED14, RGR1 mediator of RNA polymerase II transcription subunit 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15156 Q16U49 279 1.1e-23 Mediator of RNA polymerase II transcription subunit 14 OS=Aedes aegypti GN=MED14 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43232 BP_3 654.13 7.38 4564 642915809 XP_008200087.1 1290 7.7e-139 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 594 1.6e-59 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501//PF01450 AMP-binding enzyme//Acetohydroxy acid isomeroreductase, catalytic domain GO:0009099//GO:0055114//GO:0015940//GO:0009098//GO:0009097//GO:0008152//GO:0009082 valine biosynthetic process//oxidation-reduction process//pantothenate biosynthetic process//leucine biosynthetic process//isoleucine biosynthetic process//metabolic process//branched-chain amino acid biosynthetic process GO:0004455//GO:0003824 ketol-acid reductoisomerase activity//catalytic activity -- -- -- -- Cluster-8309.43235 BP_3 1590.88 14.18 5699 91078042 XP_966587.1 1300 6.7e-140 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 792 2.2e-82 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43236 BP_3 59.43 0.95 3312 642920773 XP_008192554.1 2909 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: spondin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 895 1.5e-94 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.43238 BP_3 263.66 10.45 1508 91079304 XP_966317.1 1568 1.5e-171 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 647 3.8e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.43239 BP_3 69.21 2.05 1916 642933080 XP_008197251.1 1014 3.3e-107 PREDICTED: ribosome biogenesis regulatory protein homolog [Tribolium castaneum] 795027340 XM_012006858.1 35 3.01444e-06 PREDICTED: Vollenhovia emeryi ribosome biogenesis regulatory protein homolog (LOC105558919), mRNA K14852 RRS1 regulator of ribosome biosynthesis http://www.genome.jp/dbget-bin/www_bget?ko:K14852 Q2KIH4 604 4.7e-61 Ribosome biogenesis regulatory protein homolog OS=Bos taurus GN=RRS1 PE=2 SV=1 PF04939 Ribosome biogenesis regulatory protein (RRS1) GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1765 Regulator of ribosome synthesis Cluster-8309.4324 BP_3 22.00 3.50 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43240 BP_3 266.61 5.53 2616 642935586 XP_008198071.1 3030 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform M isoform X9 [Tribolium castaneum] 642935585 XM_008199849.1 1006 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X11, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 Q9W4T4 2356 4.5e-264 cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I OS=Drosophila melanogaster GN=dnc PE=1 SV=2 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.43241 BP_3 324.79 1.81 8930 478251476 ENN71939.1 1947 9.9e-215 hypothetical protein YQE_11373, partial [Dendroctonus ponderosae] 642917170 XM_966698.2 42 1.82943e-09 PREDICTED: Tribolium castaneum centrosomin (LOC660470), transcript variant X2, mRNA K16718 CNN centrosomin http://www.genome.jp/dbget-bin/www_bget?ko:K16718 Q54G05 303 1.8e-25 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF07926//PF07989//PF04406//PF01608//PF03938//PF00831//PF02183 TPR/MLP1/MLP2-like protein//Centrosomin N-terminal motif 1//Type IIB DNA topoisomerase//I/LWEQ domain//Outer membrane protein (OmpH-like)//Ribosomal L29 protein//Homeobox associated leucine zipper GO:0042254//GO:0006606//GO:0006355//GO:0006412//GO:0006259 ribosome biogenesis//protein import into nucleus//regulation of transcription, DNA-templated//translation//DNA metabolic process GO:0003779//GO:0005524//GO:0003700//GO:0043565//GO:0051082//GO:0003735//GO:0003677//GO:0003824 actin binding//ATP binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//unfolded protein binding//structural constituent of ribosome//DNA binding//catalytic activity GO:0005815//GO:0005622//GO:0005840//GO:0005667//GO:0005694 microtubule organizing center//intracellular//ribosome//transcription factor complex//chromosome -- -- Cluster-8309.43244 BP_3 199.75 6.02 1891 642917401 XP_008191181.1 1711 4.9e-188 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like [Tribolium castaneum] 167777849 CP000786.1 38 6.39301e-08 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome I, complete sequence -- -- -- -- A1L258 1469 2.3e-161 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF01565//PF02913 FAD binding domain//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0050660//GO:0003824//GO:0016491 flavin adenine dinucleotide binding//catalytic activity//oxidoreductase activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.43245 BP_3 39.45 0.32 6306 642928768 XP_008195553.1 4946 0.0e+00 PREDICTED: ATPase, class II, type 9B isoform X2 [Tribolium castaneum] 342356458 JF265057.1 79 3.48561e-30 Heliconius melpomene cythera ribosomal protein L29 (RpL29) mRNA, complete cds K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3572 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF01779//PF00122 Ribosomal L29e protein family//E1-E2 ATPase GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0000166//GO:0046872 structural constituent of ribosome//nucleotide binding//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular KOG0210 P-type ATPase Cluster-8309.43246 BP_3 198.67 3.54 2997 642923800 XP_008193888.1 1414 2.1e-153 PREDICTED: uncharacterized protein LOC663689 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04999 Cell division protein FtsL GO:0051301//GO:0007049 cell division//cell cycle -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.43248 BP_3 246.46 2.79 4557 546684844 ERL94426.1 2530 1.3e-282 hypothetical protein D910_11704 [Dendroctonus ponderosae] -- -- -- -- -- K01769 E4.6.1.2 guanylate cyclase, other http://www.genome.jp/dbget-bin/www_bget?ko:K01769 Q9VEU5 1448 1.5e-158 Soluble guanylate cyclase 89Db OS=Drosophila melanogaster GN=Gyc-89Db PE=1 SV=1 PF00211//PF08144//PF07700//PF02285//PF07701 Adenylate and Guanylate cyclase catalytic domain//CPL (NUC119) domain//Haem-NO-binding//Cytochrome oxidase c subunit VIII//Heme NO binding associated GO:0006144//GO:0006123//GO:0046039//GO:0006182//GO:0015992//GO:0009190//GO:0035556 purine nucleobase metabolic process//mitochondrial electron transport, cytochrome c to oxygen//GTP metabolic process//cGMP biosynthetic process//proton transport//cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0003723//GO:0004129//GO:0020037//GO:0016849//GO:0004383 RNA binding//cytochrome-c oxidase activity//heme binding//phosphorus-oxygen lyase activity//guanylate cyclase activity GO:0045277 respiratory chain complex IV KOG4171 Adenylate/guanylate kinase Cluster-8309.43249 BP_3 13.36 0.31 2347 270004866 EFA01314.1 267 1.7e-20 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P4P2 235 3.5e-18 Fibrinogen C domain-containing protein 1 OS=Xenopus tropicalis GN=fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43251 BP_3 481.52 12.01 2224 642919898 XP_008192116.1 1330 8.7e-144 PREDICTED: mucin-17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43252 BP_3 3129.30 28.74 5540 270005377 EFA01825.1 2214 6.7e-246 hypothetical protein TcasGA2_TC007427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43254 BP_3 41.49 1.27 1861 642923726 XP_008193858.1 270 5.9e-21 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43256 BP_3 1011.00 15.36 3465 478262485 ENN81156.1 3139 0.0e+00 hypothetical protein YQE_02522, partial [Dendroctonus ponderosae] 642911150 XM_008202380.1 416 0 PREDICTED: Tribolium castaneum rho GTPase-activating protein 39 (LOC660972), mRNA -- -- -- -- Q9C0H5 959 5.8e-102 Rho GTPase-activating protein 39 OS=Homo sapiens GN=ARHGAP39 PE=1 SV=2 PF00784//PF00620//PF00397 MyTH4 domain//RhoGAP domain//WW domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.43257 BP_3 1025.30 4.76 10665 642911349 XP_008199384.1 4239 0.0e+00 PREDICTED: uncharacterized protein LOC659886 isoform X1 [Tribolium castaneum] 642911358 XM_008201167.1 137 3.38462e-62 PREDICTED: Tribolium castaneum uncharacterized LOC659886 (LOC659886), transcript variant X6, mRNA -- -- -- -- B6RSP1 355 2.0e-31 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.43258 BP_3 69.35 0.42 8254 91094517 XP_971992.1 691 4.0e-69 PREDICTED: protein TEX261 isoform X2 [Tribolium castaneum] 665817572 XM_008559342.1 66 7.69934e-23 PREDICTED: Microplitis demolitor iron-sulfur cluster assembly 1 homolog, mitochondrial (LOC103578320), partial mRNA K13628 iscA, ISCA1 iron-sulfur cluster assembly protein http://www.genome.jp/dbget-bin/www_bget?ko:K13628 Q4QRC6 514 5.5e-50 Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Danio rerio GN=isca1 PE=2 SV=1 PF12317//PF07882 Intraflagellar transport complex B protein 46 C terminal//L-fucose isomerase, second N-terminal domain GO:0006004//GO:0006013//GO:0006000//GO:0042073 fucose metabolic process//mannose metabolic process//fructose metabolic process//intraciliary transport GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm KOG1120 Fe-S cluster biosynthesis protein ISA1 (contains a HesB-like domain) Cluster-8309.43259 BP_3 96.47 1.60 3193 546677672 ERL88466.1 763 7.0e-78 hypothetical protein D910_05852, partial [Dendroctonus ponderosae] 462342680 APGK01035633.1 36 1.40624e-06 Dendroctonus ponderosae Seq01035643, whole genome shotgun sequence -- -- -- -- Q7SXT7 291 1.5e-24 Zinc finger C2HC domain-containing protein 1A OS=Danio rerio GN=zc2hc1a PE=2 SV=1 PF02964//PF01155//PF00096//PF04690//PF15168 Methane monooxygenase, hydrolase gamma chain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//YABBY protein//Triple QxxK/R motif-containing protein family GO:0007275//GO:0006464//GO:0015947//GO:0006118 multicellular organismal development//cellular protein modification process//methane metabolic process//obsolete electron transport GO:0016151//GO:0046872//GO:0015049 nickel cation binding//metal ion binding//methane monooxygenase activity GO:0005789//GO:0015050 endoplasmic reticulum membrane//methane monooxygenase complex KOG3940 Uncharacterized conserved protein Cluster-8309.43261 BP_3 38.01 0.66 3074 642931611 XP_971230.2 3097 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase isoform X1 [Tribolium castaneum] 808137240 XR_001099267.1 138 2.69082e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 2.9e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.43262 BP_3 165.36 2.68 3269 642931611 XP_971230.2 2719 1.1e-304 PREDICTED: sphingomyelin phosphodiesterase isoform X1 [Tribolium castaneum] 808137240 XR_001099267.1 138 2.86354e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 3.1e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.43263 BP_3 249.92 7.15 1977 642931613 XP_008196656.1 3053 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase isoform X2 [Tribolium castaneum] 808137240 XR_001099267.1 138 1.72061e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 1.9e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.43264 BP_3 230.50 1.72 6768 642920095 XP_008192202.1 1751 4.0e-192 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 7.49454e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.1e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43265 BP_3 2299.36 33.61 3589 642924886 XP_008194084.1 2016 4.0e-223 PREDICTED: serine/threonine-protein kinase MST4 isoform X2 [Tribolium castaneum] 642924885 XM_008195862.1 465 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase MST4 (LOC103313200), transcript variant X3, mRNA K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 Q99KH8 1092 2.3e-117 Serine/threonine-protein kinase 24 OS=Mus musculus GN=Stk24 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0201 Serine/threonine protein kinase Cluster-8309.43266 BP_3 201.23 2.50 4169 642926804 XP_008195020.1 1279 1.3e-137 PREDICTED: vacuole membrane protein 1 isoform X2 [Tribolium castaneum] 241594857 XM_002404356.1 107 6.25702e-46 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q6INE8 937 2.5e-99 Vacuole membrane protein 1 OS=Xenopus laevis GN=vmp1 PE=2 SV=1 PF00323 Mammalian defensin GO:0006952 defense response -- -- GO:0005576 extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.43267 BP_3 2075.35 11.86 8726 270001102 EEZ97549.1 1832 2.1e-201 hypothetical protein TcasGA2_TC011399 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZW4 179 4.1e-11 Dentin sialophosphoprotein OS=Homo sapiens GN=DSPP PE=1 SV=2 PF04433//PF03931 SWIRM domain//Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- -- -- Cluster-8309.43268 BP_3 668.69 2.18 15108 826444743 XP_012531039.1 5828 0.0e+00 PREDICTED: voltage-dependent calcium channel type A subunit alpha-1 isoform X7 [Monomorium pharaonis] 259906454 NM_001165911.1 940 0 Tribolium castaneum cacophony A (Cac), mRNA >gnl|BL_ORD_ID|7385018 Tribolium castaneum cacophony A (CAC) mRNA, complete cds -- -- -- -- C9D7C2 3178 0.0e+00 Voltage-dependent calcium channel type A subunit alpha-1 OS=Apis mellifera GN=CAC PE=2 SV=1 PF02561//PF14138//PF13405//PF00036//PF00230//PF00520//PF01635 Flagellar protein FliS//Cytochrome c oxidase assembly protein COX16//EF-hand domain//EF hand//Major intrinsic protein//Ion transport protein//Coronavirus M matrix/glycoprotein GO:0055085//GO:0019058//GO:0006810//GO:0006811 transmembrane transport//viral life cycle//transport//ion transport GO:0005215//GO:0005216//GO:0005509 transporter activity//ion channel activity//calcium ion binding GO:0009288//GO:0016020//GO:0031966 bacterial-type flagellum//membrane//mitochondrial membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.43271 BP_3 1075.33 26.63 2238 642921254 XP_008192785.1 1716 1.5e-188 PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|642921256|ref|XP_008192787.1| PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|270006236|gb|EFA02684.1| hypothetical protein TcasGA2_TC008405 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q9VL78 1056 2.1e-113 FK506-binding protein 59 OS=Drosophila melanogaster GN=FKBP59 PE=1 SV=1 PF13174//PF13181//PF13414//PF00254//PF13176//PF04434//PF13371//PF00515 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//SWIM zinc finger//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.43273 BP_3 114.92 5.26 1344 642910765 XP_008193399.1 1384 2.9e-150 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10473//PF07926 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus GO:0045502//GO:0008134//GO:0042803 dynein binding//transcription factor binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.43275 BP_3 1559.71 13.65 5799 820805554 AKG92768.1 605 2.6e-59 cropped [Leptinotarsa decemlineata] -- -- -- -- -- K09108 TFAP4 transcription factor AP-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09108 Q01664 164 1.5e-09 Transcription factor AP-4 OS=Homo sapiens GN=TFAP4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43280 BP_3 354.00 9.58 2072 -- -- -- -- -- 642917898 XM_008193153.1 95 1.44542e-39 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43281 BP_3 26.19 0.53 2677 642917897 XP_008191374.1 2213 4.2e-246 PREDICTED: nuclear hormone receptor FTZ-F1 isoform X2 [Tribolium castaneum] 642917896 XM_008193152.1 723 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1606 4.2e-177 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00105//PF00104//PF00288 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor//GHMP kinases N terminal domain GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0003700//GO:0043565//GO:0008270 ATP binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.43282 BP_3 56.45 0.59 4868 478254660 ENN74901.1 1209 2.0e-129 hypothetical protein YQE_08479, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12109 CXCR4 Chemokine receptor N terminal -- -- GO:0019955 cytokine binding -- -- -- -- Cluster-8309.43283 BP_3 298.09 16.98 1138 332373134 AEE61708.1 1176 3.2e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00913 ITPK1 inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00913 Q7ZU91 615 1.5e-62 Inositol-tetrakisphosphate 1-kinase OS=Danio rerio GN=itpk1 PE=2 SV=2 PF02655//PF05770 ATP-grasp domain//Inositol 1, 3, 4-trisphosphate 5/6-kinase GO:0032957 inositol trisphosphate metabolic process GO:0052725//GO:0046872//GO:0000287//GO:0052726//GO:0005524//GO:0047325 inositol-1,3,4-trisphosphate 6-kinase activity//metal ion binding//magnesium ion binding//inositol-1,3,4-trisphosphate 5-kinase activity//ATP binding//inositol tetrakisphosphate 1-kinase activity GO:0005622 intracellular -- -- Cluster-8309.43287 BP_3 1718.20 41.01 2311 91087799 XP_967345.1 3105 0.0e+00 PREDICTED: threonine--tRNA ligase, cytoplasmic isoform X2 [Tribolium castaneum] 572269851 XM_006612875.1 387 0 PREDICTED: Apis dorsata threonine--tRNA ligase, cytoplasmic-like (LOC102672191), transcript variant X2, mRNA K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q9D0R2 2689 9.6e-303 Threonine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Tars PE=1 SV=2 PF00587//PF07973 tRNA synthetase class II core domain (G, H, P, S and T)//Threonyl and Alanyl tRNA synthetase second additional domain GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0005524//GO:0000166//GO:0016876//GO:0004812 ATP binding//nucleotide binding//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.43288 BP_3 15.83 1.09 992 478249797 ENN70304.1 667 2.9e-67 hypothetical protein YQE_12815, partial [Dendroctonus ponderosae] -- -- -- -- -- K17785 IMMT, FCJ1, MNOS2 mitofilin http://www.genome.jp/dbget-bin/www_bget?ko:K17785 P91928 452 1.0e-43 MICOS complex subunit Mic60 OS=Drosophila melanogaster GN=Mitofilin PE=1 SV=4 -- -- -- -- -- -- -- -- KOG1854 Mitochondrial inner membrane protein (mitofilin) Cluster-8309.43289 BP_3 273.32 4.79 3044 642923201 XP_008193653.1 948 2.3e-99 PREDICTED: apoptotic chromatin condensation inducer in the nucleus [Tribolium castaneum]>gi|270007592|gb|EFA04040.1| hypothetical protein TcasGA2_TC014271 [Tribolium castaneum] -- -- -- -- -- K12875 ACIN1, ACINUS apoptotic chromatin condensation inducer in the nucleus http://www.genome.jp/dbget-bin/www_bget?ko:K12875 Q9JIX8 284 9.5e-24 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus GN=Acin1 PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2416 Acinus (induces apoptotic chromatin condensation) Cluster-8309.43290 BP_3 23.52 0.38 3257 642923201 XP_008193653.1 929 4.0e-97 PREDICTED: apoptotic chromatin condensation inducer in the nucleus [Tribolium castaneum]>gi|270007592|gb|EFA04040.1| hypothetical protein TcasGA2_TC014271 [Tribolium castaneum] -- -- -- -- -- K12875 ACIN1, ACINUS apoptotic chromatin condensation inducer in the nucleus http://www.genome.jp/dbget-bin/www_bget?ko:K12875 Q9JIX8 284 1.0e-23 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus GN=Acin1 PE=1 SV=3 PF05887//PF00076 Procyclic acidic repetitive protein (PARP)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding GO:0016020 membrane KOG2416 Acinus (induces apoptotic chromatin condensation) Cluster-8309.43291 BP_3 1384.65 11.68 6007 642911463 XP_008199434.1 1028 2.4e-108 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF15220//PF03323 MAP7 (E-MAP-115) family//Hypoxia-inducible lipid droplet-associated//Bacillus/Clostridium GerA spore germination protein GO:0000226//GO:0010884//GO:0001819//GO:0009847//GO:0008284 microtubule cytoskeleton organization//positive regulation of lipid storage//positive regulation of cytokine production//spore germination//positive regulation of cell proliferation -- -- GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane -- -- Cluster-8309.43292 BP_3 827.11 7.68 5482 642937541 XP_008199088.1 4421 0.0e+00 PREDICTED: ribonuclease 3 [Tribolium castaneum] 820865686 XM_012493878.1 559 0 PREDICTED: Apis florea ribonuclease 3 (LOC100863432), mRNA K03685 rnc, DROSHA, RNT1 ribonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K03685 Q9NRR4 2767 2.1e-311 Ribonuclease 3 OS=Homo sapiens GN=DROSHA PE=1 SV=2 PF00636//PF14622 Ribonuclease III domain//Ribonuclease-III-like GO:0051252//GO:0006396 regulation of RNA metabolic process//RNA processing GO:0003723//GO:0004525 RNA binding//ribonuclease III activity -- -- KOG1817 Ribonuclease Cluster-8309.43293 BP_3 2050.24 36.97 2965 646694595 KDR08043.1 2640 1.4e-295 hypothetical protein L798_02197 [Zootermopsis nevadensis] 808134796 XM_003399528.2 277 1.39426e-140 PREDICTED: Bombus terrestris uncharacterized LOC100647816 (LOC100647816), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43294 BP_3 297.06 4.51 3464 642938815 XP_008199930.1 763 7.5e-78 PREDICTED: uncharacterized protein LOC103314794 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-8309.43295 BP_3 279.52 5.52 2733 571330972 AHF27418.1 1958 1.6e-216 putative sugar transporter 4_2 [Phaedon cochleariae] 195586810 XM_002083125.1 43 1.54308e-10 Drosophila simulans GD13586 (Dsim\GD13586), mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 P20303 942 4.3e-100 Solute carrier family 2, facilitated glucose transporter member 1 OS=Sus scrofa GN=SLC2A1 PE=2 SV=2 PF08157//PF07690//PF00083 NUC129 domain//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0569 Permease of the major facilitator superfamily Cluster-8309.43296 BP_3 22.52 1.07 1307 668458368 KFB46282.1 1732 1.2e-190 AGAP004610-PA-like protein [Anopheles sinensis] 820863197 XM_012492833.1 398 0 PREDICTED: Apis florea signal recognition particle 54 kDa protein (LOC105736738), partial mRNA K03106 SRP54, ffh signal recognition particle subunit SRP54 http://www.genome.jp/dbget-bin/www_bget?ko:K03106 P14576 1576 6.2e-174 Signal recognition particle 54 kDa protein OS=Mus musculus GN=Srp54 PE=1 SV=2 PF01583//PF01926//PF01591//PF00004//PF02978//PF00448//PF02881//PF06414//PF04851//PF03205//PF10662 Adenylylsulphate kinase//50S ribosome-binding GTPase//6-phosphofructo-2-kinase//ATPase family associated with various cellular activities (AAA)//Signal peptide binding domain//SRP54-type protein, GTPase domain//SRP54-type protein, helical bundle domain//Zeta toxin//Type III restriction enzyme, res subunit//Molybdopterin guanine dinucleotide synthesis protein B//Ethanolamine utilisation - propanediol utilisation GO:0006000//GO:0006777//GO:0006614//GO:0006013//GO:0006144//GO:0000103//GO:0006576 fructose metabolic process//Mo-molybdopterin cofactor biosynthetic process//SRP-dependent cotranslational protein targeting to membrane//mannose metabolic process//purine nucleobase metabolic process//sulfate assimilation//cellular biogenic amine metabolic process GO:0016301//GO:0005524//GO:0016787//GO:0008312//GO:0005525//GO:0003873//GO:0004020//GO:0003677 kinase activity//ATP binding//hydrolase activity//7S RNA binding//GTP binding//6-phosphofructo-2-kinase activity//adenylylsulfate kinase activity//DNA binding GO:0048500 signal recognition particle KOG0780 Signal recognition particle, subunit Srp54 Cluster-8309.43297 BP_3 1344.35 60.66 1360 817068229 XP_012256040.1 1888 1.0e-208 PREDICTED: signal recognition particle 54 kDa protein [Athalia rosae] 242009195 XM_002425332.1 477 0 Pediculus humanus corporis Signal recognition particle 54 kDa protein, putative, mRNA K03106 SRP54, ffh signal recognition particle subunit SRP54 http://www.genome.jp/dbget-bin/www_bget?ko:K03106 P14576 1716 3.8e-190 Signal recognition particle 54 kDa protein OS=Mus musculus GN=Srp54 PE=1 SV=2 PF03205//PF04851//PF06414//PF10662//PF01583//PF01926//PF00004//PF02978//PF01591//PF02881//PF00448 Molybdopterin guanine dinucleotide synthesis protein B//Type III restriction enzyme, res subunit//Zeta toxin//Ethanolamine utilisation - propanediol utilisation//Adenylylsulphate kinase//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Signal peptide binding domain//6-phosphofructo-2-kinase//SRP54-type protein, helical bundle domain//SRP54-type protein, GTPase domain GO:0006000//GO:0006777//GO:0006614//GO:0006013//GO:0000103//GO:0006144//GO:0006576 fructose metabolic process//Mo-molybdopterin cofactor biosynthetic process//SRP-dependent cotranslational protein targeting to membrane//mannose metabolic process//sulfate assimilation//purine nucleobase metabolic process//cellular biogenic amine metabolic process GO:0016301//GO:0016787//GO:0005524//GO:0005525//GO:0008312//GO:0004020//GO:0003873//GO:0003677 kinase activity//hydrolase activity//ATP binding//GTP binding//7S RNA binding//adenylylsulfate kinase activity//6-phosphofructo-2-kinase activity//DNA binding GO:0048500 signal recognition particle KOG0780 Signal recognition particle, subunit Srp54 Cluster-8309.43299 BP_3 364.76 3.24 5726 478250173 ENN70676.1 1254 1.4e-134 hypothetical protein YQE_12621, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q88168 578 1.5e-57 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF03153//PF04111//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Transcription factor IIA, alpha/beta subunit//Autophagy protein Apg6//Glycosyltransferase family 28 C-terminal domain GO:0006914//GO:0006367//GO:0008152 autophagy//transcription initiation from RNA polymerase II promoter//metabolic process GO:0016758 transferase activity, transferring hexosyl groups GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.43302 BP_3 1591.14 66.16 1451 91081971 XP_967978.1 987 3.3e-104 PREDICTED: plexin domain-containing protein 2 [Tribolium castaneum]>gi|270007319|gb|EFA03767.1| hypothetical protein TcasGA2_TC013878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DC11 523 8.8e-52 Plexin domain-containing protein 2 OS=Mus musculus GN=Plxdc2 PE=1 SV=1 PF01437 Plexin repeat -- -- -- -- GO:0016020 membrane KOG3848 Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) Cluster-8309.43303 BP_3 213.00 7.08 1742 642929509 XP_975022.2 1897 1.2e-209 PREDICTED: protein CLP1 homolog [Tribolium castaneum] -- -- -- -- -- K14399 CLP1, HERB polyribonucleotide 5'-hydroxyl-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14399 Q7QJW7 1503 2.4e-165 Protein CLP1 homolog OS=Anopheles gambiae GN=cbc PE=3 SV=2 PF06807//PF01926 Pre-mRNA cleavage complex II protein Clp1//50S ribosome-binding GTPase GO:0031124 mRNA 3'-end processing GO:0005525 GTP binding -- -- KOG2749 mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1 Cluster-8309.43304 BP_3 276.59 8.16 1926 91076494 XP_972946.1 541 2.3e-52 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 394 1.1e-36 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43305 BP_3 19.60 0.48 2268 642935314 XP_008197964.1 1039 4.9e-110 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X13 [Tribolium castaneum] 780158183 XM_011684374.1 51 4.56411e-15 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 Q9VJE5 559 9.2e-56 Restin homolog OS=Drosophila melanogaster GN=CLIP-190 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43306 BP_3 127.36 1.15 5625 642935280 XP_008197946.1 1202 1.5e-128 PREDICTED: adenosine receptor A2a [Tribolium castaneum] -- -- -- -- -- K04266 ADORA2A, ADOR adenosine receptor A2a http://www.genome.jp/dbget-bin/www_bget?ko:K04266 O13076 453 4.5e-43 Adenosine receptor A2b OS=Gallus gallus GN=ADORA2B PE=2 SV=1 PF10716//PF00643//PF00001 NADH dehydrogenase transmembrane subunit//B-box zinc finger//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0006118//GO:0055114 G-protein coupled receptor signaling pathway//obsolete electron transport//oxidation-reduction process GO:0004930//GO:0008270//GO:0016655 G-protein coupled receptor activity//zinc ion binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.43307 BP_3 87.52 1.79 2654 91081405 XP_972749.1 1686 5.4e-185 PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|642920827|ref|XP_008192575.1| PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|270005174|gb|EFA01622.1| hypothetical protein TcasGA2_TC007191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ3 751 5.9e-78 T-complex protein 11-like protein 1 OS=Homo sapiens GN=TCP11L1 PE=1 SV=1 PF03310//PF12689 Caulimovirus DNA-binding protein//Acid Phosphatase -- -- GO:0003677//GO:0016791 DNA binding//phosphatase activity -- -- KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family Cluster-8309.43308 BP_3 87.70 1.62 2901 91081405 XP_972749.1 1686 5.9e-185 PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|642920827|ref|XP_008192575.1| PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|270005174|gb|EFA01622.1| hypothetical protein TcasGA2_TC007191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ3 751 6.4e-78 T-complex protein 11-like protein 1 OS=Homo sapiens GN=TCP11L1 PE=1 SV=1 PF12689//PF03310 Acid Phosphatase//Caulimovirus DNA-binding protein -- -- GO:0003677//GO:0016791 DNA binding//phosphatase activity -- -- KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family Cluster-8309.43309 BP_3 1726.95 36.55 2569 91081405 XP_972749.1 1798 5.4e-198 PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|642920827|ref|XP_008192575.1| PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|270005174|gb|EFA01622.1| hypothetical protein TcasGA2_TC007191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ3 754 2.5e-78 T-complex protein 11-like protein 1 OS=Homo sapiens GN=TCP11L1 PE=1 SV=1 PF03310//PF12689 Caulimovirus DNA-binding protein//Acid Phosphatase -- -- GO:0003677//GO:0016791 DNA binding//phosphatase activity -- -- KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family Cluster-8309.43310 BP_3 1340.91 36.82 2047 546675018 ERL86281.1 1576 2.4e-172 hypothetical protein D910_03690 [Dendroctonus ponderosae] -- -- -- -- -- K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 Q58DW2 1175 3.1e-127 Cystathionine gamma-lyase OS=Bos taurus GN=CTH PE=2 SV=1 PF00155//PF01212//PF01053 Aminotransferase class I and II//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.43311 BP_3 312.27 2.68 5910 642916978 XP_008199580.1 1043 4.4e-110 PREDICTED: leukocyte receptor cluster member 8 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CBY3 733 1.6e-75 Leukocyte receptor cluster member 8 homolog OS=Mus musculus GN=Leng8 PE=1 SV=1 PF02978//PF01785 Signal peptide binding domain//Closterovirus coat protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0019012//GO:0048500 virion//signal recognition particle KOG1861 Leucine permease transcriptional regulator Cluster-8309.43312 BP_3 176.65 17.23 786 478251617 ENN72078.1 335 7.3e-29 hypothetical protein YQE_11264, partial [Dendroctonus ponderosae]>gi|546674549|gb|ERL85905.1| hypothetical protein D910_03320 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BW72 223 2.9e-17 HIG1 domain family member 2A, mitochondrial OS=Homo sapiens GN=HIGD2A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4431 Uncharacterized protein, induced by hypoxia Cluster-8309.43314 BP_3 50.41 1.11 2481 189239692 XP_967139.2 1102 2.7e-117 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 68 1.77287e-24 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 751 5.5e-78 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2736 Presenilin Cluster-8309.43317 BP_3 218.54 3.59 3224 672273128 KFG45225.1 147 1.9e-06 IgA-specific metalloendopeptidase [Toxoplasma gondii GAB2-2007-GAL-DOM2] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03502 Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279 cell outer membrane -- -- Cluster-8309.43318 BP_3 10759.65 93.34 5848 270007317 EFA03765.1 2886 0.0e+00 hypothetical protein TcasGA2_TC013876 [Tribolium castaneum] 642921924 XM_008194725.1 121 1.45168e-53 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4 gamma 3-like (LOC656935), transcript variant X3, mRNA K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 O43432 889 1.3e-93 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens GN=EIF4G3 PE=1 SV=2 PF02020//PF05372//PF02854 eIF4-gamma/eIF5/eIF2-epsilon//Delta lysin family//MIF4G domain GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515//GO:0003723 protein binding//RNA binding GO:0005576 extracellular region KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.43319 BP_3 102.92 1.01 5200 642921925 XP_008192947.1 2157 2.6e-239 PREDICTED: eukaryotic translation initiation factor 4 gamma 3-like isoform X3 [Tribolium castaneum] 642921924 XM_008194725.1 121 1.28983e-53 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4 gamma 3-like (LOC656935), transcript variant X3, mRNA K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 O43432 889 1.1e-93 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens GN=EIF4G3 PE=1 SV=2 PF02020//PF02854//PF05372 eIF4-gamma/eIF5/eIF2-epsilon//MIF4G domain//Delta lysin family GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515//GO:0003723 protein binding//RNA binding GO:0005576 extracellular region KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.43321 BP_3 346.90 4.79 3785 642932100 XP_008196854.1 1534 3.3e-167 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.24608e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.8e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF00622//PF07525//PF01213 SPRY domain//SOCS box//Adenylate cyclase associated (CAP) N terminal GO:0007010//GO:0035556 cytoskeleton organization//intracellular signal transduction GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.43322 BP_3 29.08 1.17 1488 478250604 ENN71096.1 296 4.6e-24 hypothetical protein YQE_12029, partial [Dendroctonus ponderosae]>gi|546673100|gb|ERL84769.1| hypothetical protein D910_02194 [Dendroctonus ponderosae] 290756693 GU580820.1 73 1.74985e-27 Drepana curvatula voucher NS48 glyceraldhyde-3-phosphate dehydrogenase (GAPDH) gene, partial cds >gnl|BL_ORD_ID|8311285 Thyatira batis voucher MM00027 glyceraldhyde-3-phosphate dehydrogenase (GAPDH) gene, partial cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 P32636 283 6.1e-24 Glyceraldehyde-3-phosphate dehydrogenase 2 OS=Agaricus bisporus GN=gpd2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.43323 BP_3 8.00 83.78 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43324 BP_3 16.30 0.57 1658 844837396 XP_012792468.1 207 1.1e-13 Chromobox protein 8 [Schistosoma haematobium]>gi|685956510|gb|KGB32687.1| Chromobox protein 8 [Schistosoma haematobium] -- -- -- -- -- K11455 CBX8, PC3 chromobox protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11455 Q9HC52 162 7.3e-10 Chromobox protein homolog 8 OS=Homo sapiens GN=CBX8 PE=1 SV=3 PF01552//PF06524 Picornavirus 2B protein//NOA36 protein GO:0006508//GO:0018144//GO:0006144 proteolysis//RNA-protein covalent cross-linking//purine nucleobase metabolic process GO:0000166//GO:0003968//GO:0008234//GO:0008270//GO:0016779//GO:0008233//GO:0016787//GO:0016740//GO:0005198 nucleotide binding//RNA-directed RNA polymerase activity//cysteine-type peptidase activity//zinc ion binding//nucleotidyltransferase activity//peptidase activity//hydrolase activity//transferase activity//structural molecule activity GO:0031379//GO:0005634//GO:0019012 RNA-directed RNA polymerase complex//nucleus//virion KOG2748 Uncharacterized conserved protein, contains chromo domain Cluster-8309.43325 BP_3 30.39 2.37 909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43326 BP_3 583.83 3.56 8188 642929719 XP_008195949.1 2566 1.5e-286 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.82431e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q14738 2003 1.2e-222 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens GN=PPP2R5D PE=1 SV=1 PF01695//PF07728//PF05496//PF01603//PF06068//PF00004//PF07724 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily) GO:0006310//GO:0006281//GO:0007165 DNA recombination//DNA repair//signal transduction GO:0009378//GO:0016887//GO:0008601//GO:0005524//GO:0003678 four-way junction helicase activity//ATPase activity//protein phosphatase type 2A regulator activity//ATP binding//DNA helicase activity GO:0000159//GO:0009379//GO:0005657 protein phosphatase type 2A complex//Holliday junction helicase complex//replication fork KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.43330 BP_3 414.20 3.99 5293 189234120 XP_968578.2 724 3.8e-73 PREDICTED: tetraspanin-13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17356 TSPAN13_31 tetraspanin-13/31 http://www.genome.jp/dbget-bin/www_bget?ko:K17356 Q5XHG6 407 9.0e-38 Tetraspanin-31-A OS=Xenopus laevis GN=tspan31-a PE=2 SV=1 PF00076//PF07574//PF00335//PF11837 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Nse1 non-SMC component of SMC5-6 complex//Tetraspanin family//Domain of unknown function (DUF3357) GO:0006012//GO:0005985//GO:0005982//GO:0006281 galactose metabolic process//sucrose metabolic process//starch metabolic process//DNA repair GO:0004575//GO:0003676//GO:0004564 sucrose alpha-glucosidase activity//nucleic acid binding//beta-fructofuranosidase activity GO:0030915//GO:0016021//GO:0017177 Smc5-Smc6 complex//integral component of membrane//glucosidase II complex KOG4208 Nucleolar RNA-binding protein NIFK Cluster-8309.43331 BP_3 217.55 2.69 4190 642912156 XP_008200829.1 841 8.2e-87 PREDICTED: tetraspanin-13 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17356 TSPAN13_31 tetraspanin-13/31 http://www.genome.jp/dbget-bin/www_bget?ko:K17356 Q5XHG6 499 1.5e-48 Tetraspanin-31-A OS=Xenopus laevis GN=tspan31-a PE=2 SV=1 PF00076//PF11654//PF11837//PF00335//PF07574 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Protein of unknown function (DUF2665)//Domain of unknown function (DUF3357)//Tetraspanin family//Nse1 non-SMC component of SMC5-6 complex GO:0009306//GO:0006281//GO:0005982//GO:0006012//GO:0005985 protein secretion//DNA repair//starch metabolic process//galactose metabolic process//sucrose metabolic process GO:0004564//GO:0003676//GO:0004575 beta-fructofuranosidase activity//nucleic acid binding//sucrose alpha-glucosidase activity GO:0017177//GO:0016021//GO:0030915 glucosidase II complex//integral component of membrane//Smc5-Smc6 complex KOG4208 Nucleolar RNA-binding protein NIFK Cluster-8309.43332 BP_3 56.90 1.04 2924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43335 BP_3 103.29 1.04 5086 642918835 XP_008191606.1 3389 0.0e+00 PREDICTED: DENN domain-containing protein 5B [Tribolium castaneum]>gi|270005624|gb|EFA02072.1| hypothetical protein TcasGA2_TC007707 [Tribolium castaneum] 571543384 XM_006559642.1 37 6.25431e-07 PREDICTED: Apis mellifera DENN domain-containing protein 5B-like (LOC412128), transcript variant X4, mRNA -- -- -- -- A2RSQ0 1529 6.9e-168 DENN domain-containing protein 5B OS=Mus musculus GN=Dennd5b PE=1 SV=2 PF01807//PF01477 CHC2 zinc finger//PLAT/LH2 domain GO:0006269//GO:0006260//GO:0006351 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated GO:0008270//GO:0003677//GO:0003896//GO:0005515 zinc ion binding//DNA binding//DNA primase activity//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2080 Uncharacterized conserved protein, contains DENN and RUN domains Cluster-8309.43338 BP_3 900.92 6.50 6977 642912703 XP_008200968.1 4488 0.0e+00 PREDICTED: cytoskeleton-associated protein 5 [Tribolium castaneum]>gi|270002915|gb|EEZ99362.1| mini spindles [Tribolium castaneum] 642912702 XM_008202746.1 130 1.72066e-58 PREDICTED: Tribolium castaneum cytoskeleton-associated protein 5 (LOC659068), mRNA K16803 CKAP5, XMAP215 cytoskeleton-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16803 Q14008 1971 5.3e-219 Cytoskeleton-associated protein 5 OS=Homo sapiens GN=CKAP5 PE=1 SV=3 PF08465//PF02985//PF12422//PF11640 Thymidine kinase from Herpesvirus C-terminal//HEAT repeat//Condensin II non structural maintenance of chromosomes subunit//Telomere-length maintenance and DNA damage repair GO:0006206//GO:0016310//GO:0009069//GO:0006230 pyrimidine nucleobase metabolic process//phosphorylation//serine family amino acid metabolic process//TMP biosynthetic process GO:0004674//GO:0005515//GO:0004797//GO:0005524 protein serine/threonine kinase activity//protein binding//thymidine kinase activity//ATP binding GO:0005634 nucleus KOG1820 Microtubule-associated protein Cluster-8309.43339 BP_3 124.95 3.40 2063 546678750 ERL89302.1 1360 2.7e-147 hypothetical protein D910_06674 [Dendroctonus ponderosae] -- -- -- -- -- K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 -- -- -- -- PF05656//PF12106 Protein of unknown function (DUF805)//Colicin C terminal ribonuclease domain GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.43340 BP_3 17.00 0.49 1953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43343 BP_3 1130.02 5.14 10883 270005270 EFA01718.1 2859 0.0e+00 hypothetical protein TcasGA2_TC007298 [Tribolium castaneum] 642920291 XM_008194064.1 631 0 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 9-like (LOC664510), transcript variant X1, mRNA K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 Q3U1V8 1444 1.1e-157 Mitogen-activated protein kinase kinase kinase 9 OS=Mus musculus GN=Map3k9 PE=2 SV=2 PF00069//PF14604//PF00018//PF03938//PF07714//PF03102 Protein kinase domain//Variant SH3 domain//SH3 domain//Outer membrane protein (OmpH-like)//Protein tyrosine kinase//NeuB family GO:0016051//GO:0006468 carbohydrate biosynthetic process//protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0051082 protein binding//protein kinase activity//ATP binding//unfolded protein binding -- -- -- -- Cluster-8309.43345 BP_3 35.90 0.49 3834 270005270 EFA01718.1 703 7.6e-71 hypothetical protein TcasGA2_TC007298 [Tribolium castaneum] -- -- -- -- -- K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43346 BP_3 1390.21 29.03 2600 642919248 XP_008191793.1 999 2.4e-105 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|642919250|ref|XP_008191794.1| PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|270005765|gb|EFA02213.1| hypothetical protein TcasGA2_TC007872 [Tribolium castaneum] 170068618 XM_001868902.1 84 2.37113e-33 Culex quinquefasciatus cation efflux protein/ zinc transporter, mRNA K14688 SLC30A1, ZNT1 solute carrier family 30 (zinc transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14688 Q60738 372 5.1e-34 Zinc transporter 1 OS=Mus musculus GN=Slc30a1 PE=1 SV=1 PF01545 Cation efflux family GO:0006812//GO:0055085 cation transport//transmembrane transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.43347 BP_3 445.00 8.82 2723 642920080 XP_001816051.2 1083 4.6e-115 PREDICTED: uncharacterized protein LOC100142030 [Tribolium castaneum] 817217709 XM_012429347.1 55 3.28103e-17 PREDICTED: Orussus abietinus uncharacterized LOC105702077 (LOC105702077), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43348 BP_3 311.53 2.57 6144 270003480 EEZ99927.1 1716 4.2e-188 hypothetical protein TcasGA2_TC002723 [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 252 9.9e-20 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 PF03554//PF03110 UL73 viral envelope glycoprotein//SBP domain -- -- GO:0003677 DNA binding GO:0019031//GO:0005634 viral envelope//nucleus KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.43349 BP_3 40.59 0.62 3458 642911043 XP_008193521.1 1799 5.6e-198 PREDICTED: histone deacetylase 6 [Tribolium castaneum] -- -- -- -- -- K11407 HDAC6 histone deacetylase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11407 Q9Z2V5 1328 9.4e-145 Histone deacetylase 6 OS=Mus musculus GN=Hdac6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.43352 BP_3 1007.62 11.57 4488 642916691 XP_008192180.1 4543 0.0e+00 PREDICTED: membrane-bound transcription factor site-1 protease isoform X1 [Tribolium castaneum] 768954933 XM_003976835.2 102 4.05641e-43 PREDICTED: Takifugu rubripes membrane-bound transcription factor site-1 protease-like (LOC101078346), partial mRNA K08653 MBTPS1 membrane-bound transcription factor site-1 protease http://www.genome.jp/dbget-bin/www_bget?ko:K08653 Q9Z2A8 3338 0.0e+00 Membrane-bound transcription factor site-1 protease OS=Cricetulus griseus GN=MBTPS1 PE=1 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.43356 BP_3 1708.14 19.29 4560 91077054 XP_966585.1 1457 3.3e-158 PREDICTED: probable transaldolase [Tribolium castaneum]>gi|270001740|gb|EEZ98187.1| hypothetical protein TcasGA2_TC000616 [Tribolium castaneum] 746851965 XM_011058220.1 116 6.80068e-51 PREDICTED: Acromyrmex echinatior probable transaldolase (LOC105147307), mRNA K00616 E2.2.1.2, talA, talB transaldolase http://www.genome.jp/dbget-bin/www_bget?ko:K00616 Q9EQS0 1175 6.9e-127 Transaldolase OS=Rattus norvegicus GN=Taldo1 PE=1 SV=2 PF00560//PF00646//PF00923//PF15966//PF02428//PF13855//PF12937 Leucine Rich Repeat//F-box domain//Transaldolase//F-box//Potato type II proteinase inhibitor family//Leucine rich repeat//F-box-like GO:0005975//GO:0006098 carbohydrate metabolic process//pentose-phosphate shunt GO:0005515//GO:0004801//GO:0004867 protein binding//sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity//serine-type endopeptidase inhibitor activity GO:0005737 cytoplasm KOG2772 Transaldolase Cluster-8309.43357 BP_3 479.29 15.73 1760 642920404 XP_008192334.1 397 1.1e-35 PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum]>gi|642920406|ref|XP_967709.2| PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43358 BP_3 359.91 5.57 3407 478250209 ENN70712.1 1705 4.4e-187 hypothetical protein YQE_12657, partial [Dendroctonus ponderosae]>gi|546683975|gb|ERL93709.1| hypothetical protein D910_10996 [Dendroctonus ponderosae] -- -- -- -- -- K14807 DDX51, DBP6 ATP-dependent RNA helicase DDX51/DBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K14807 P26802 957 9.7e-102 Probable ATP-dependent RNA helicase Dbp73D OS=Drosophila melanogaster GN=Dbp73D PE=2 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0350 DEAD-box ATP-dependent RNA helicase Cluster-8309.4336 BP_3 4.24 0.46 734 752862307 XP_011262094.1 209 2.8e-14 PREDICTED: leucine-rich repeat-containing protein 71-like [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9D3W5 143 5.1e-08 Leucine-rich repeat-containing protein 71 OS=Mus musculus GN=Lrrc71 PE=2 SV=1 PF00560 Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43360 BP_3 9.75 0.51 1220 642917784 XP_008191285.1 743 5.5e-76 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X2 [Tribolium castaneum] -- -- -- -- -- K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 637 4.5e-65 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF08332 Calcium/calmodulin dependent protein kinase II association domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004683//GO:0005516 calmodulin-dependent protein kinase activity//calmodulin binding -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.43362 BP_3 106.02 1.07 5058 642928921 XP_008195617.1 6951 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] 642928920 XM_008197395.1 1020 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 3949 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF02985//PF00443 HEAT repeat//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0005515 ubiquitinyl hydrolase activity//protein binding -- -- -- -- Cluster-8309.43363 BP_3 39.93 0.31 6470 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.4e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF01331//PF09266//PF01279//PF13606//PF00023 mRNA capping enzyme, catalytic domain//Viral DNA topoisomerase I, N-terminal//Parathyroid hormone family//Ankyrin repeat//Ankyrin repeat GO:0006397//GO:0007165//GO:0006370//GO:0006265 mRNA processing//signal transduction//7-methylguanosine mRNA capping//DNA topological change GO:0003677//GO:0004484//GO:0005515//GO:0003916//GO:0005179 DNA binding//mRNA guanylyltransferase activity//protein binding//DNA topoisomerase activity//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.43366 BP_3 46.73 2.43 1219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43370 BP_3 126.75 1.28 5069 642924833 XP_008194059.1 824 9.3e-85 PREDICTED: IST1 homolog isoform X4 [Tribolium castaneum]>gi|270008007|gb|EFA04455.1| hypothetical protein TcasGA2_TC014759 [Tribolium castaneum] -- -- -- -- -- K19476 IST1 vacuolar protein sorting-associated protein IST1 http://www.genome.jp/dbget-bin/www_bget?ko:K19476 Q3ZBV1 568 1.9e-56 IST1 homolog OS=Bos taurus GN=IST1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2027 Spindle pole body protein Cluster-8309.43371 BP_3 806.37 8.03 5133 642924827 XP_008194056.1 824 9.4e-85 PREDICTED: IST1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K19476 IST1 vacuolar protein sorting-associated protein IST1 http://www.genome.jp/dbget-bin/www_bget?ko:K19476 Q3ZBV1 568 1.9e-56 IST1 homolog OS=Bos taurus GN=IST1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2027 Spindle pole body protein Cluster-8309.43372 BP_3 20.10 0.51 2186 642927866 XP_008195431.1 712 3.9e-72 PREDICTED: ankyrin repeat and LEM domain-containing protein 1 [Tribolium castaneum]>gi|270010254|gb|EFA06702.1| hypothetical protein TcasGA2_TC009633 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFX9 163 7.3e-10 Tankyrase-1 OS=Mus musculus GN=Tnks PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.43373 BP_3 14253.15 518.38 1617 642928332 XP_008195538.1 991 1.3e-104 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81139 364 2.7e-33 Pancreatic lipase-related protein 2 OS=Cavia porcellus GN=PNLIPRP2 PE=1 SV=1 PF00975//PF01764//PF00326//PF06821//PF07819//PF07859 Thioesterase domain//Lipase (class 3)//Prolyl oligopeptidase family//Serine hydrolase//PGAP1-like protein//alpha/beta hydrolase fold GO:0006886//GO:0006629//GO:0006505//GO:0008152//GO:0009058//GO:0006508 intracellular protein transport//lipid metabolic process//GPI anchor metabolic process//metabolic process//biosynthetic process//proteolysis GO:0016787//GO:0016788//GO:0008236 hydrolase activity//hydrolase activity, acting on ester bonds//serine-type peptidase activity -- -- -- -- Cluster-8309.43374 BP_3 285.25 15.01 1208 642928332 XP_008195538.1 647 7.4e-65 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q17RR3 280 1.1e-23 Pancreatic lipase-related protein 3 OS=Homo sapiens GN=PNLIPRP3 PE=2 SV=2 PF01764//PF06821//PF00326//PF07819//PF00975 Lipase (class 3)//Serine hydrolase//Prolyl oligopeptidase family//PGAP1-like protein//Thioesterase domain GO:0009058//GO:0006508//GO:0006629//GO:0006886//GO:0006505 biosynthetic process//proteolysis//lipid metabolic process//intracellular protein transport//GPI anchor metabolic process GO:0008236//GO:0016788//GO:0016787 serine-type peptidase activity//hydrolase activity, acting on ester bonds//hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.43375 BP_3 2.09 0.40 546 826436136 XP_012529352.1 607 1.5e-60 PREDICTED: ubiquitin-conjugating enzyme E2 G2 [Monomorium pharaonis] 827562182 XM_004933089.2 86 3.66e-35 PREDICTED: Bombyx mori ubiquitin-conjugating enzyme E2 G2 (LOC101745353), mRNA K04555 UBE2G2, UBC7 ubiquitin-conjugating enzyme E2 G2 http://www.genome.jp/dbget-bin/www_bget?ko:K04555 Q17QG5 542 2.1e-54 Ubiquitin-conjugating enzyme E2 G2 OS=Bos taurus GN=UBE2G2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0426 Ubiquitin-protein ligase Cluster-8309.43376 BP_3 403.00 17.26 1417 91090934 XP_974343.1 871 9.2e-91 PREDICTED: ribosome maturation protein SBDS [Tribolium castaneum]>gi|270013208|gb|EFA09656.1| hypothetical protein TcasGA2_TC011782 [Tribolium castaneum] -- -- -- -- -- K14574 SDO1, SBDS ribosome maturation protein SDO1 http://www.genome.jp/dbget-bin/www_bget?ko:K14574 Q3SWZ6 774 6.7e-81 Ribosome maturation protein SBDS OS=Bos taurus GN=SBDS PE=2 SV=1 PF09377 SBDS protein C-terminal domain GO:0042254 ribosome biogenesis -- -- -- -- KOG2917 Predicted exosome subunit Cluster-8309.43377 BP_3 138.75 1.24 5688 642936070 XP_008198290.1 2843 0.0e+00 PREDICTED: protein phosphatase Slingshot isoform X2 [Tribolium castaneum] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 1461 5.9e-160 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.43378 BP_3 1463.56 12.11 6119 91090936 XP_974392.1 3149 0.0e+00 PREDICTED: protein phosphatase Slingshot isoform X1 [Tribolium castaneum] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 1461 6.3e-160 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.43379 BP_3 1830.68 15.60 5947 270014017 EFA10465.1 3006 0.0e+00 hypothetical protein TcasGA2_TC012711 [Tribolium castaneum] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 1461 6.1e-160 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.43381 BP_3 3873.68 12.46 15273 642931869 XP_008196762.1 2259 1.1e-250 PREDICTED: protein split ends isoform X1 [Tribolium castaneum] 642931870 XM_008198541.1 278 2.0151e-140 PREDICTED: Tribolium castaneum protein split ends (LOC661278), transcript variant X2, mRNA -- -- -- -- Q8SX83 1148 3.1e-123 Protein split ends OS=Drosophila melanogaster GN=spen PE=1 SV=2 PF00335//PF04406//PF02532//PF16367//PF00076 Tetraspanin family//Type IIB DNA topoisomerase//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006259//GO:0015979 DNA metabolic process//photosynthesis GO:0003676//GO:0005524//GO:0003824//GO:0003677 nucleic acid binding//ATP binding//catalytic activity//DNA binding GO:0005694//GO:0016020//GO:0009539//GO:0009523//GO:0016021 chromosome//membrane//photosystem II reaction center//photosystem II//integral component of membrane KOG0112 Large RNA-binding protein (RRM superfamily) Cluster-8309.43382 BP_3 249.94 4.66 2878 642929390 XP_008195816.1 919 5.1e-96 PREDICTED: cysteine dioxygenase type 1 [Tribolium castaneum]>gi|270010522|gb|EFA06970.1| hypothetical protein TcasGA2_TC009929 [Tribolium castaneum] -- -- -- -- -- K00456 CDO1 cysteine dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00456 Q6NWZ9 594 1.0e-59 Cysteine dioxygenase type 1 OS=Danio rerio GN=cdo1 PE=2 SV=1 PF07847//PF05995 Protein of unknown function (DUF1637)//Cysteine dioxygenase type I GO:0055114//GO:0019530//GO:0006534//GO:0046439 oxidation-reduction process//taurine metabolic process//cysteine metabolic process//L-cysteine metabolic process GO:0016702//GO:0017172//GO:0005506 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//cysteine dioxygenase activity//iron ion binding -- -- KOG4064 Cysteine dioxygenase CDO1 Cluster-8309.43385 BP_3 481.82 14.45 1899 642926542 XP_008194914.1 1359 3.2e-147 PREDICTED: LOW QUALITY PROTEIN: arginine-glutamic acid dipeptide repeats protein [Tribolium castaneum] 766941684 XM_011505186.1 56 6.33036e-18 PREDICTED: Ceratosolen solmsi marchali arginine-glutamic acid dipeptide repeats protein (LOC105366667), mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q80TZ9 151 1.6e-08 Arginine-glutamic acid dipeptide repeats protein OS=Mus musculus GN=Rere PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4339 BP_3 5.72 0.45 910 546675056 ERL86311.1 291 1.1e-23 hypothetical protein D910_03719 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43390 BP_3 1396.82 7.76 8973 642912276 XP_008200634.1 5209 0.0e+00 PREDICTED: exportin-7 isoform X2 [Tribolium castaneum]>gi|270002549|gb|EEZ98996.1| hypothetical protein TcasGA2_TC004857 [Tribolium castaneum] 642912275 XM_008202412.1 982 0 PREDICTED: Tribolium castaneum exportin-7 (LOC655656), transcript variant X2, mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 4020 0.0e+00 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 PF03810//PF13414 Importin-beta N-terminal domain//TPR repeat GO:0006886//GO:0015031 intracellular protein transport//protein transport GO:0008565//GO:0005515//GO:0008536 protein transporter activity//protein binding//Ran GTPase binding GO:0005643 nuclear pore KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.43392 BP_3 52.80 5.49 755 478263559 ENN81893.1 243 3.3e-18 hypothetical protein YQE_01725, partial [Dendroctonus ponderosae]>gi|546678711|gb|ERL89273.1| hypothetical protein D910_06646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43393 BP_3 304.77 7.12 2355 189237332 XP_973384.2 1276 1.7e-137 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 7.82345e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.0e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.43396 BP_3 44.03 2.67 1086 91094947 XP_968721.1 1020 3.7e-108 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F3L4 728 1.1e-75 Protein DENND6A OS=Gallus gallus GN=DENND6A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2432 Uncharacterized conserved protein Cluster-8309.43398 BP_3 57.00 9.03 596 91092202 XP_969503.1 736 1.7e-75 PREDICTED: protein MEF2BNB homolog isoform X1 [Tribolium castaneum]>gi|270014438|gb|EFA10886.1| hypothetical protein TcasGA2_TC001710 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IR45 425 8.3e-41 Protein MEF2BNB homolog OS=Drosophila melanogaster GN=CG32590 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43399 BP_3 1079.99 24.13 2449 642924836 XP_008194060.1 879 1.9e-91 PREDICTED: regucalcin-like isoform X1 [Tribolium castaneum]>gi|642924838|ref|XP_008194061.1| PREDICTED: regucalcin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9TTJ5 418 2.2e-39 Regucalcin OS=Bos taurus GN=RGN PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.434 BP_3 1.00 0.40 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4340 BP_3 58.28 2.07 1648 546675056 ERL86311.1 285 9.6e-23 hypothetical protein D910_03719 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43400 BP_3 95.25 1.35 3693 91092348 XP_971306.1 1293 2.8e-139 PREDICTED: uncharacterized protein LOC659947 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0061025//GO:0046813 membrane fusion//receptor-mediated virion attachment to host cell -- -- GO:0016021//GO:0019031 integral component of membrane//viral envelope -- -- Cluster-8309.43401 BP_3 179.00 15.08 864 91077572 XP_972780.1 762 2.5e-78 PREDICTED: 39S ribosomal protein L46, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17427 MRPL46 large subunit ribosomal protein L46 http://www.genome.jp/dbget-bin/www_bget?ko:K17427 Q5RK00 453 6.8e-44 39S ribosomal protein L46, mitochondrial OS=Rattus norvegicus GN=Mrpl46 PE=2 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4548 Mitochondrial ribosomal protein L17 Cluster-8309.43402 BP_3 1074.64 17.56 3241 642920454 XP_008192357.1 1382 1.2e-149 PREDICTED: protein croquemort isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 956 1.2e-101 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.43403 BP_3 380.60 7.00 2913 91083737 XP_970914.1 1523 4.7e-166 PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|642924379|ref|XP_008194272.1| PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|270007890|gb|EFA04338.1| hypothetical protein TcasGA2_TC014632 [Tribolium castaneum] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 Q8QZR1 889 6.4e-94 Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1 SV=1 PF01212//PF01053//PF00155//PF02854 Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II//MIF4G domain GO:0016070//GO:0009058//GO:0006520 RNA metabolic process//biosynthetic process//cellular amino acid metabolic process GO:0003723//GO:0003677//GO:0030170//GO:0005515//GO:0016829 RNA binding//DNA binding//pyridoxal phosphate binding//protein binding//lyase activity -- -- KOG0259 Tyrosine aminotransferase Cluster-8309.43404 BP_3 163.89 2.19 3893 478254062 ENN74354.1 272 7.3e-21 hypothetical protein YQE_09324, partial [Dendroctonus ponderosae]>gi|546672807|gb|ERL84563.1| hypothetical protein D910_01992 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43408 BP_3 142.95 0.60 11796 478257995 ENN78133.1 3235 0.0e+00 hypothetical protein YQE_05287, partial [Dendroctonus ponderosae] -- -- -- -- -- K02324 POLE1 DNA polymerase epsilon subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02324 Q07864 2778 3.8e-312 DNA polymerase epsilon catalytic subunit A OS=Homo sapiens GN=POLE PE=1 SV=5 PF00136//PF00322//PF02177//PF03104//PF00711//PF13482//PF05405//PF08115 DNA polymerase family B//Endothelin family//Amyloid A4 N-terminal heparin-binding//DNA polymerase family B, exonuclease domain//Beta defensin//RNase_H superfamily//Mitochondrial ATP synthase B chain precursor (ATP-synt_B)//SFI toxin family GO:0015992//GO:0015986//GO:0006952//GO:0019229//GO:0009405 proton transport//ATP synthesis coupled proton transport//defense response//regulation of vasoconstriction//pathogenesis GO:0008201//GO:0000166//GO:0008408//GO:0015078//GO:0003676//GO:0003677 heparin binding//nucleotide binding//3'-5' exonuclease activity//hydrogen ion transmembrane transporter activity//nucleic acid binding//DNA binding GO:0005576 extracellular region KOG1798 DNA polymerase epsilon, catalytic subunit A Cluster-8309.43410 BP_3 348.55 2.52 6955 189241642 XP_970294.2 3267 0.0e+00 PREDICTED: uncharacterized protein LOC658848 isoform X1 [Tribolium castaneum] 642937292 XM_965201.3 298 6.9764e-152 PREDICTED: Tribolium castaneum uncharacterized LOC658848 (LOC658848), transcript variant X1, mRNA -- -- -- -- Q70EL1 1065 6.0e-114 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Homo sapiens GN=USP54 PE=1 SV=4 PF00126//PF00443 Bacterial regulatory helix-turn-helix protein, lysR family//Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0006355 protein deubiquitination//regulation of transcription, DNA-templated GO:0003700//GO:0036459 transcription factor activity, sequence-specific DNA binding//ubiquitinyl hydrolase activity GO:0005667 transcription factor complex KOG1887 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.43412 BP_3 40.55 0.35 5935 751224154 XP_011165403.1 320 3.0e-26 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08103 Uperin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.43414 BP_3 120.07 0.56 10561 322788321 EFZ14035.1 495 2.7e-46 hypothetical protein SINV_15106, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06484 Teneurin Intracellular Region GO:0007165 signal transduction -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.43417 BP_3 13.75 1.91 638 642931516 XP_001808926.2 221 9.8e-16 PREDICTED: uncharacterized protein LOC100141678 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.43418 BP_3 206.06 1.71 6090 332372732 AEE61508.1 572 1.9e-55 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 396 2.0e-36 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF03370//PF15826//PF00191//PF08294//PF02936 Carbohydrate/starch-binding module (family 21)//Bcl-2-binding component 3, p53 upregulated modulator of apoptosis//Annexin//TIM21//Cytochrome c oxidase subunit IV GO:0030150//GO:0006123//GO:0097193//GO:0043065//GO:0015992//GO:0090200 protein import into mitochondrial matrix//mitochondrial electron transport, cytochrome c to oxygen//intrinsic apoptotic signaling pathway//positive regulation of apoptotic process//proton transport//positive regulation of release of cytochrome c from mitochondria GO:0005515//GO:0004129//GO:0005544//GO:0005509 protein binding//cytochrome-c oxidase activity//calcium-dependent phospholipid binding//calcium ion binding GO:0045277//GO:0005744//GO:0005739 respiratory chain complex IV//mitochondrial inner membrane presequence translocase complex//mitochondrion KOG0819 Annexin Cluster-8309.43419 BP_3 546.12 4.33 6369 642936968 XP_008198633.1 774 7.4e-79 PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936970|ref|XP_008198634.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936972|ref|XP_008198636.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936974|ref|XP_008198637.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936976|ref|XP_008198638.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13709 137 2.2e-06 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 PF01397//PF04055 Terpene synthase, N-terminal domain//Radical SAM superfamily GO:0008152 metabolic process GO:0016829//GO:0010333//GO:0003824//GO:0051536 lyase activity//terpene synthase activity//catalytic activity//iron-sulfur cluster binding -- -- -- -- Cluster-8309.43422 BP_3 721.22 8.85 4220 642918982 XP_008191684.1 4673 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.31414e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.43423 BP_3 11666.62 451.93 1536 264667393 ACY71282.1 1027 8.2e-109 ribosomal protein S5 [Chrysomela tremula] 269118352 GQ865409.1 223 7.45718e-111 Catacroptera cloanthe voucher NW88-1 ribosomal protein S5 (RpS5) gene, partial cds K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 Q5E988 942 2.4e-100 40S ribosomal protein S5 OS=Bos taurus GN=RPS5 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-8309.43424 BP_3 347.75 2.42 7222 642918773 XP_008191578.1 3024 0.0e+00 PREDICTED: calpain-D-like isoform X2 [Tribolium castaneum] 194768179 XM_001966155.1 141 1.3674e-64 Drosophila ananassae GF19541 (Dana\GF19541), mRNA K08582 CAPN15 calpain-15 http://www.genome.jp/dbget-bin/www_bget?ko:K08582 P27398 1456 2.8e-159 Calpain-D OS=Drosophila melanogaster GN=sol PE=1 SV=2 PF00648//PF00641 Calpain family cysteine protease//Zn-finger in Ran binding protein and others GO:0006508 proteolysis GO:0008270//GO:0004198 zinc ion binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.43425 BP_3 143.98 1.92 3905 270014442 EFA10890.1 3189 0.0e+00 hypothetical protein TcasGA2_TC001714 [Tribolium castaneum] 642911942 XM_008200810.1 429 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1277 8.8e-139 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF14604//PF00023//PF00018//PF13606//PF01412//PF07043 Variant SH3 domain//Ankyrin repeat//SH3 domain//Ankyrin repeat//Putative GTPase activating protein for Arf//Protein of unknown function (DUF1328) -- -- GO:0005515//GO:0005096 protein binding//GTPase activator activity GO:0005886 plasma membrane KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.43427 BP_3 27.18 0.43 3370 642924682 XP_008194395.1 1980 5.6e-219 PREDICTED: voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [Tribolium castaneum] 642924681 XM_008196173.1 612 0 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X4, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 1238 2.5e-134 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF12052//PF08437//PF00018//PF01424 Voltage gated calcium channel subunit beta domain 4Aa N terminal//Glycosyl transferase family 8 C-terminal//SH3 domain//R3H domain GO:0009103//GO:0006816//GO:0070588 lipopolysaccharide biosynthetic process//calcium ion transport//calcium ion transmembrane transport GO:0005515//GO:0003676//GO:0005245//GO:0008918 protein binding//nucleic acid binding//voltage-gated calcium channel activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0005891 voltage-gated calcium channel complex KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.43428 BP_3 86.67 5.29 1081 270004596 EFA01044.1 1146 9.1e-123 hypothetical protein TcasGA2_TC003960 [Tribolium castaneum] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q8C8R3 587 2.5e-59 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.43429 BP_3 13.19 0.69 1219 546671620 ERL83854.1 1028 4.9e-109 hypothetical protein D910_01121 [Dendroctonus ponderosae] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q8C8R3 551 4.2e-55 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.43433 BP_3 2749.65 11.89 11435 642917156 XP_008191141.1 5897 0.0e+00 PREDICTED: filamin-A [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 793 3.4e-82 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 PF03110//PF03554//PF03547 SBP domain//UL73 viral envelope glycoprotein//Membrane transport protein GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0019031//GO:0005634//GO:0016021 viral envelope//nucleus//integral component of membrane KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.43435 BP_3 1.00 22.75 223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43438 BP_3 1.00 1.93 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43441 BP_3 1648.00 16.34 5153 478255854 ENN76062.1 464 5.3e-43 hypothetical protein YQE_07434, partial [Dendroctonus ponderosae]>gi|546680453|gb|ERL90719.1| hypothetical protein D910_08066 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q58D45 215 1.6e-15 Cell death-inducing p53-target protein 1 OS=Bos taurus GN=CDIP1 PE=2 SV=1 PF04113 Gpi16 subunit, GPI transamidase component GO:0016255 attachment of GPI anchor to protein -- -- GO:0042765 GPI-anchor transamidase complex -- -- Cluster-8309.43442 BP_3 107.00 16.89 597 478253101 ENN73474.1 270 1.9e-21 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02454 Sigma 1s protein GO:0019048 modulation by virus of host morphology or physiology -- -- -- -- -- -- Cluster-8309.43443 BP_3 173.75 1.19 7305 642935187 XP_008199684.1 1340 2.0e-144 PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|642935189|ref|XP_008199685.1| PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|270014202|gb|EFA10650.1| hypothetical protein TcasGA2_TC016287 [Tribolium castaneum] 558226116 XM_006137153.1 62 1.13958e-20 PREDICTED: Pelodiscus sinensis tetratricopeptide repeat domain 1 (TTC1), transcript variant X3, mRNA K12386 CTNS cystinosin http://www.genome.jp/dbget-bin/www_bget?ko:K12386 Q9VCR7 1014 5.1e-108 Cystinosin homolog OS=Drosophila melanogaster GN=CG17119 PE=1 SV=2 PF13374//PF00515//PF13371//PF04194//PF13176//PF00522//PF13414//PF13181//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Programmed cell death protein 2, C-terminal putative domain//Tetratricopeptide repeat//VPR/VPX protein//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019058 viral life cycle GO:0005515 protein binding GO:0042025//GO:0005737 host cell nucleus//cytoplasm KOG3145 Cystine transporter Cystinosin Cluster-8309.43445 BP_3 15.56 0.83 1194 642922873 XP_008200433.1 1484 6.5e-162 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [Tribolium castaneum]>gi|270006562|gb|EFA03010.1| hypothetical protein TcasGA2_TC010433 [Tribolium castaneum] 195346084 XM_002039563.1 253 1.21163e-127 Drosophila sechellia GM22642 (Dsec\GM22642), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q2KJI2 1258 4.3e-137 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Bos taurus GN=STT3A PE=2 SV=1 PF02516//PF10034 Oligosaccharyl transferase STT3 subunit//Q-cell neuroblast polarisation GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0016020//GO:0016021//GO:0008250 membrane//integral component of membrane//oligosaccharyltransferase complex KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.43449 BP_3 48.35 0.47 5251 478255990 ENN76189.1 1139 2.9e-121 hypothetical protein YQE_07157, partial [Dendroctonus ponderosae] 755992161 XM_011314822.1 134 7.72929e-61 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 710 6.6e-73 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00549//PF13508//PF00583//PF08445//PF13673 CoA-ligase//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein//Acetyltransferase (GNAT) domain GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0003824//GO:0008080//GO:0016747 catalytic activity//N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.4345 BP_3 4.00 0.53 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43450 BP_3 41.89 0.64 3443 642919071 XP_008191721.1 3346 0.0e+00 PREDICTED: MAP kinase-activating death domain protein isoform X2 [Tribolium castaneum] 780680996 XM_011699227.1 91 4.04413e-37 PREDICTED: Wasmannia auropunctata MAP kinase-activating death domain protein (LOC105455707), transcript variant X7, mRNA -- -- -- -- Q9VXY2 2480 2.5e-278 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane KOG3570 MAPK-activating protein DENN Cluster-8309.43452 BP_3 118.80 1.27 4791 189238796 XP_974873.2 4310 0.0e+00 PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|642927324|ref|XP_008195221.1| PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|270009983|gb|EFA06431.1| hypothetical protein TcasGA2_TC009311 [Tribolium castaneum] 817212881 XM_012427217.1 176 3.16493e-84 PREDICTED: Orussus abietinus paired amphipathic helix protein Sin3a (LOC105700923), transcript variant X6, mRNA K11644 SIN3A paired amphipathic helix protein Sin3a http://www.genome.jp/dbget-bin/www_bget?ko:K11644 Q96ST3 1682 1.2e-185 Paired amphipathic helix protein Sin3a OS=Homo sapiens GN=SIN3A PE=1 SV=2 PF06390//PF02671 Neuroendocrine-specific golgi protein P55 (NESP55)//Paired amphipathic helix repeat GO:0006355//GO:0071107 regulation of transcription, DNA-templated//response to parathyroid hormone -- -- GO:0005634 nucleus KOG4204 Histone deacetylase complex, SIN3 component Cluster-8309.43453 BP_3 903.35 11.48 4083 189238796 XP_974873.2 4310 0.0e+00 PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|642927324|ref|XP_008195221.1| PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|270009983|gb|EFA06431.1| hypothetical protein TcasGA2_TC009311 [Tribolium castaneum] 817212881 XM_012427217.1 176 2.69369e-84 PREDICTED: Orussus abietinus paired amphipathic helix protein Sin3a (LOC105700923), transcript variant X6, mRNA K11644 SIN3A paired amphipathic helix protein Sin3a http://www.genome.jp/dbget-bin/www_bget?ko:K11644 Q96ST3 1682 1.0e-185 Paired amphipathic helix protein Sin3a OS=Homo sapiens GN=SIN3A PE=1 SV=2 PF06390//PF02671 Neuroendocrine-specific golgi protein P55 (NESP55)//Paired amphipathic helix repeat GO:0006355//GO:0071107 regulation of transcription, DNA-templated//response to parathyroid hormone -- -- GO:0005634 nucleus KOG4204 Histone deacetylase complex, SIN3 component Cluster-8309.43454 BP_3 1.00 3.93 271 642929424 XP_008195834.1 330 9.4e-29 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07022//PF04218//PF01527 Bacteriophage CI repressor helix-turn-helix domain//CENP-B N-terminal DNA-binding domain//Transposase GO:0045892//GO:0006313 negative regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-8309.43455 BP_3 159.12 0.40 19481 642929422 XP_008195833.1 3477 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] 642929421 XM_008197611.1 179 2.7798e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q7TMR0 1024 9.5e-109 Lysosomal Pro-X carboxypeptidase OS=Mus musculus GN=Prcp PE=2 SV=2 PF05577//PF16367//PF00076//PF08273//PF01221//PF01429//PF07647//PF01609//PF08926//PF11789//PF02198//PF04564//PF06638//PF00326//PF00400//PF00130//PF00536//PF00439//PF00628//PF14634//PF04574 Serine carboxypeptidase S28//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc-binding domain of primase-helicase//Dynein light chain type 1//Methyl-CpG binding domain//SAM domain (Sterile alpha motif)//Transposase DDE domain//Domain of unknown function (DUF1908)//Zinc-finger of the MIZ type in Nse subunit//Sterile alpha motif (SAM)/Pointed domain//U-box domain//Strabismus protein//Prolyl oligopeptidase family//WD domain, G-beta repeat//Phorbol esters/diacylglycerol binding domain (C1 domain)//SAM domain (Sterile alpha motif)//Bromodomain//PHD-finger//zinc-RING finger domain//Protein of unknown function (DUF592) GO:0007017//GO:0006355//GO:0006468//GO:0009069//GO:0006807//GO:0006351//GO:0006476//GO:0006313//GO:0006269//GO:0035556//GO:0006508//GO:0006342//GO:0007275//GO:0016310//GO:0016567 microtubule-based process//regulation of transcription, DNA-templated//protein phosphorylation//serine family amino acid metabolic process//nitrogen compound metabolic process//transcription, DNA-templated//protein deacetylation//transposition, DNA-mediated//DNA replication, synthesis of RNA primer//intracellular signal transduction//proteolysis//chromatin silencing//multicellular organismal development//phosphorylation//protein ubiquitination GO:0043565//GO:0008270//GO:0016811//GO:0003896//GO:0017136//GO:0000287//GO:0004386//GO:0003677//GO:0051287//GO:0005515//GO:0004674//GO:0008236//GO:0005524//GO:0003676//GO:0004803//GO:0004842 sequence-specific DNA binding//zinc ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//DNA primase activity//NAD-dependent histone deacetylase activity//magnesium ion binding//helicase activity//DNA binding//NAD binding//protein binding//protein serine/threonine kinase activity//serine-type peptidase activity//ATP binding//nucleic acid binding//transposase activity//ubiquitin-protein transferase activity GO:0005875//GO:0016021//GO:0005657//GO:0005634//GO:0005730//GO:0000118 microtubule associated complex//integral component of membrane//replication fork//nucleus//nucleolus//histone deacetylase complex KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.43457 BP_3 312.53 5.46 3053 646722695 KDR23609.1 3011 0.0e+00 Periodic tryptophan protein 2-like protein [Zootermopsis nevadensis] -- -- -- -- -- K14558 PWP2, UTP1 periodic tryptophan protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14558 Q15269 2291 1.8e-256 Periodic tryptophan protein 2 homolog OS=Homo sapiens GN=PWP2 PE=1 SV=2 PF08625//PF01764//PF02031//PF00400//PF04192//PF09142//PF04617 Utp13 specific WD40 associated domain//Lipase (class 3)//Streptomyces extracellular neutral proteinase (M7) family//WD domain, G-beta repeat//Utp21 specific WD40 associated putative domain//tRNA Pseudouridine synthase II, C terminal//Hox9 activation region GO:0006351//GO:0006629//GO:0006508//GO:0006364//GO:0009451//GO:0001522 transcription, DNA-templated//lipid metabolic process//proteolysis//rRNA processing//RNA modification//pseudouridine synthesis GO:0004222//GO:0003723//GO:0005515//GO:0008270//GO:0009982 metalloendopeptidase activity//RNA binding//protein binding//zinc ion binding//pseudouridine synthase activity GO:0005634//GO:0005576//GO:0032040 nucleus//extracellular region//small-subunit processome KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.43458 BP_3 238.17 13.84 1121 91089925 XP_972979.1 1326 1.3e-143 PREDICTED: target of rapamycin complex subunit lst8 [Tribolium castaneum] -- -- -- -- -- K08266 GBL G protein beta subunit-like http://www.genome.jp/dbget-bin/www_bget?ko:K08266 Q803V5 1081 1.3e-116 Target of rapamycin complex subunit lst8 OS=Danio rerio GN=mlst8 PE=2 SV=1 PF00400//PF02897 WD domain, G-beta repeat//Prolyl oligopeptidase, N-terminal beta-propeller domain -- -- GO:0070008//GO:0005515//GO:0004252 serine-type exopeptidase activity//protein binding//serine-type endopeptidase activity -- -- KOG0315 G-protein beta subunit-like protein (contains WD40 repeats) Cluster-8309.43460 BP_3 8.24 0.31 1566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43461 BP_3 195.92 8.54 1397 642936242 XP_008198362.1 1634 3.1e-179 PREDICTED: polypyrimidine tract-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 781 1.0e-81 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.43462 BP_3 10.50 0.33 1817 642924469 XP_008194311.1 910 3.6e-95 PREDICTED: transcription factor Sox-2 [Tribolium castaneum]>gi|270008130|gb|EFA04578.1| Sox21b [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12336 SOX transcription factor GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.43465 BP_3 934.14 12.46 3904 91087975 XP_973241.1 1366 1.0e-147 PREDICTED: wiskott-Aldrich syndrome protein family member 3 [Tribolium castaneum]>gi|270012052|gb|EFA08500.1| hypothetical protein TcasGA2_TC006152 [Tribolium castaneum] -- -- -- -- -- K06220 WASF WAS protein family http://www.genome.jp/dbget-bin/www_bget?ko:K06220 Q9UPY6 601 2.1e-60 Wiskott-Aldrich syndrome protein family member 3 OS=Homo sapiens GN=WASF3 PE=1 SV=2 PF03358//PF07415//PF02205 NADPH-dependent FMN reductase//Gammaherpesvirus latent membrane protein (LMP2) protein//WH2 motif GO:0019042 viral latency GO:0003779//GO:0016491 actin binding//oxidoreductase activity GO:0033644 host cell membrane KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.43466 BP_3 39.28 1.37 1671 91092400 XP_969218.1 697 1.6e-70 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 279 2.0e-23 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43467 BP_3 11.29 0.84 937 557018159 XP_006009466.1 304 3.4e-25 PREDICTED: uncharacterized protein LOC102349681 isoform X1 [Latimeria chalumnae]>gi|557018161|ref|XP_006009467.1| PREDICTED: uncharacterized protein LOC102349681 isoform X2 [Latimeria chalumnae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02419 PsbL protein GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.43468 BP_3 407.00 16.78 1461 91081949 XP_967168.1 561 8.4e-55 PREDICTED: uncharacterized protein C18orf19 homolog B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5CZQ0 302 3.7e-26 Uncharacterized protein C18orf19 homolog B OS=Danio rerio GN=zgc:113036 PE=2 SV=1 PF01442//PF00448//PF13361//PF01610//PF13965 Apolipoprotein A1/A4/E domain//SRP54-type protein, GTPase domain//UvrD-like helicase C-terminal domain//Transposase//dsRNA-gated channel SID-1 GO:0006869//GO:0006313//GO:0042157//GO:0015931//GO:0006614//GO:0033227 lipid transport//transposition, DNA-mediated//lipoprotein metabolic process//nucleobase-containing compound transport//SRP-dependent cotranslational protein targeting to membrane//dsRNA transport GO:0016787//GO:0003677//GO:0008289//GO:0005524//GO:0004803//GO:0051033//GO:0005525 hydrolase activity//DNA binding//lipid binding//ATP binding//transposase activity//RNA transmembrane transporter activity//GTP binding GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG4082 Uncharacterized conserved protein Cluster-8309.43471 BP_3 54.78 0.35 7775 270011776 EFA08224.1 1024 9.2e-108 hypothetical protein TcasGA2_TC005851 [Tribolium castaneum] -- -- -- -- -- K17232 DUOXA2 dual oxidase maturation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17232 Q0VCL9 362 2.2e-32 Uncharacterized protein C3orf38 homolog OS=Bos taurus PE=2 SV=2 PF00096//PF04062//PF01283//PF10204//PF17123//PF00651 Zinc finger, C2H2 type//ARP2/3 complex ARPC3 (21 kDa) subunit//Ribosomal protein S26e//Dual oxidase maturation factor//RING-like zinc finger//BTB/POZ domain GO:0015031//GO:0042254//GO:0034314//GO:0006412//GO:0030833 protein transport//ribosome biogenesis//Arp2/3 complex-mediated actin nucleation//translation//regulation of actin filament polymerization GO:0046872//GO:0008270//GO:0003735//GO:0005515 metal ion binding//zinc ion binding//structural constituent of ribosome//protein binding GO:0005622//GO:0005885//GO:0005840//GO:0005789//GO:0005856//GO:0016021 intracellular//Arp2/3 protein complex//ribosome//endoplasmic reticulum membrane//cytoskeleton//integral component of membrane -- -- Cluster-8309.43472 BP_3 2.00 0.43 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43473 BP_3 62.54 1.24 2730 546678697 ERL89265.1 1371 1.9e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 3.4e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.43477 BP_3 328.78 17.76 1184 546680236 ERL90554.1 630 6.8e-63 hypothetical protein D910_07902 [Dendroctonus ponderosae] 667830835 XM_007781397.1 52 6.52966e-16 Coniosporium apollinis CBS 100218 hypothetical protein partial mRNA K10976 ERO1LB ERO1-like protein beta http://www.genome.jp/dbget-bin/www_bget?ko:K10976 Q9V3A6 428 7.4e-41 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0016671//GO:0003756 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//protein disulfide isomerase activity GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.43478 BP_3 92.91 3.40 1610 478250804 ENN71296.1 1183 7.0e-127 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10950 ERO1L ERO1-like protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K10950 Q9V3A6 913 5.8e-97 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0016671//GO:0003756 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//protein disulfide isomerase activity GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.43479 BP_3 429.57 15.85 1598 478250804 ENN71296.1 1194 3.7e-128 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10950 ERO1L ERO1-like protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K10950 Q9V3A6 924 3.1e-98 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0003756//GO:0016671 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.43481 BP_3 90.14 3.64 1484 642916321 XP_008190972.1 159 3.5e-08 PREDICTED: uncharacterized protein LOC103312341 [Tribolium castaneum] 642916320 XM_008192750.1 106 7.89231e-46 PREDICTED: Tribolium castaneum uncharacterized LOC103312341 (LOC103312341), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43484 BP_3 387.75 17.64 1351 91084201 XP_967826.1 1338 6.2e-145 PREDICTED: cyclin-dependent kinase 1 [Tribolium castaneum] 697443056 XM_009666252.1 44 2.09412e-11 PREDICTED: Struthio camelus australis cyclin-dependent kinase 3 (CDK3), partial mRNA K02087 CDK1, CDC2 cyclin-dependent kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02087 P23572 1201 2.0e-130 Cyclin-dependent kinase 1 OS=Drosophila melanogaster GN=cdc2 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.43487 BP_3 488.42 2.72 8955 646710408 KDR15927.1 1192 3.5e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.74134e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.43489 BP_3 13.00 36.38 283 642936837 XP_008197842.1 273 4.0e-22 PREDICTED: calcium-activated potassium channel slowpoke isoform X3 [Tribolium castaneum] 195504713 XM_002099161.1 68 1.81314e-25 Drosophila yakuba GE23506 (Dyak\GE23506), partial mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 267 8.3e-23 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4349 BP_3 100.00 8.82 838 91092028 XP_969359.1 1008 7.1e-107 PREDICTED: mediator of RNA polymerase II transcription subunit 18 [Tribolium castaneum]>gi|270004688|gb|EFA01136.1| hypothetical protein TcasGA2_TC010359 [Tribolium castaneum] -- -- -- -- -- K15135 MED18 mediator of RNA polymerase II transcription subunit 18 http://www.genome.jp/dbget-bin/www_bget?ko:K15135 Q17IN5 732 2.9e-76 Mediator of RNA polymerase II transcription subunit 18 OS=Aedes aegypti GN=MED18 PE=3 SV=1 PF09637 Med18 protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3264 Uncharacterized conserved protein Cluster-8309.43490 BP_3 8.00 0.47 1117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43491 BP_3 856.21 8.56 5114 270014651 EFA11099.1 3279 0.0e+00 hypothetical protein TcasGA2_TC004696 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63406 1651 4.9e-182 Guanine nucleotide exchange factor DBS OS=Rattus norvegicus GN=Mcf2l PE=1 SV=3 PF00806//PF00435//PF00018//PF14604//PF00621 Pumilio-family RNA binding repeat//Spectrin repeat//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089//GO:0003723 protein binding//Rho guanyl-nucleotide exchange factor activity//RNA binding -- -- -- -- Cluster-8309.43493 BP_3 109.00 2.95 2071 478254281 ENN74535.1 1199 1.3e-128 hypothetical protein YQE_08859, partial [Dendroctonus ponderosae]>gi|546679316|gb|ERL89803.1| hypothetical protein D910_07164 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q17EJ1 932 4.7e-99 Mitochondrial GTPase 1 OS=Aedes aegypti GN=AAEL003813 PE=3 SV=1 PF03193//PF10662//PF04548//PF00071//PF00503//PF05049//PF01926//PF08477//PF02421 Protein of unknown function, DUF258//Ethanolamine utilisation - propanediol utilisation//AIG1 family//Ras family//G-protein alpha subunit//Interferon-inducible GTPase (IIGP)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B GO:0007264//GO:0015684//GO:0007186//GO:0007165//GO:0006576 small GTPase mediated signal transduction//ferrous iron transport//G-protein coupled receptor signaling pathway//signal transduction//cellular biogenic amine metabolic process GO:0005525//GO:0004871//GO:0019001//GO:0003924//GO:0015093//GO:0005524//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//G-protein beta/gamma-subunit complex binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG2485 Conserved ATP/GTP binding protein Cluster-8309.43497 BP_3 36.00 13.86 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43499 BP_3 534.31 2.11 12506 642922986 XP_008200482.1 7208 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase TRIP12 isoform X2 [Tribolium castaneum] 642922985 XM_008202260.1 1251 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase TRIP12 (LOC658915), transcript variant X4, mRNA K10590 TRIP12 E3 ubiquitin-protein ligase TRIP12 http://www.genome.jp/dbget-bin/www_bget?ko:K10590 G5E870 4375 0.0e+00 E3 ubiquitin-protein ligase TRIP12 OS=Mus musculus GN=Trip12 PE=1 SV=1 PF13414//PF13176//PF13371//PF00515//PF13374//PF00514//PF13174//PF00632//PF04049//PF12470//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Armadillo/beta-catenin-like repeat//Tetratricopeptide repeat//HECT-domain (ubiquitin-transferase)//Anaphase promoting complex subunit 8 / Cdc23//Suppressor of Fused Gli/Ci N terminal binding domain//Tetratricopeptide repeat GO:0016567//GO:0030071 protein ubiquitination//regulation of mitotic metaphase/anaphase transition GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0170 E3 ubiquitin protein ligase Cluster-8309.4350 BP_3 4.00 76.55 227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43502 BP_3 426.00 10.30 2285 91091908 XP_966621.1 1119 2.6e-119 PREDICTED: ribosome production factor 2 homolog [Tribolium castaneum]>gi|270000797|gb|EEZ97244.1| hypothetical protein TcasGA2_TC011042 [Tribolium castaneum] -- -- -- -- -- K14847 RPF2 ribosome production factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14847 Q9VEB3 773 1.4e-80 Ribosome production factor 2 homolog OS=Drosophila melanogaster GN=CG7993 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3031 Protein required for biogenesis of the ribosomal 60S subunit Cluster-8309.43503 BP_3 9.00 24.52 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43505 BP_3 85.09 0.39 10841 270003171 EEZ99618.1 1776 8.1e-195 hypothetical protein TcasGA2_TC002136 [Tribolium castaneum] 795019206 XM_012004108.1 296 1.40938e-150 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556990 (LOC105556990), mRNA K09585 TXNDC10 thioredoxin domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09585 Q9VPF8 987 1.0e-104 Transmembrane protein 104 homolog OS=Drosophila melanogaster GN=CG5262 PE=2 SV=2 PF03222//PF01984//PF00400//PF01428//PF02073//PF00578//PF01216//PF00659//PF00085 Tryptophan/tyrosine permease family//Double-stranded DNA-binding domain//WD domain, G-beta repeat//AN1-like Zinc finger//Thermophilic metalloprotease (M29)//AhpC/TSA family//Calsequestrin//POLO box duplicated region//Thioredoxin GO:0055114//GO:0045454//GO:0003333//GO:0006508 oxidation-reduction process//cell redox homeostasis//amino acid transmembrane transport//proteolysis GO:0005515//GO:0016491//GO:0003677//GO:0005509//GO:0004177//GO:0008270//GO:0016209 protein binding//oxidoreductase activity//DNA binding//calcium ion binding//aminopeptidase activity//zinc ion binding//antioxidant activity -- -- KOG4277 Uncharacterized conserved protein, contains thioredoxin domain Cluster-8309.43506 BP_3 158.08 1.38 5801 546686097 ERL95494.1 1149 2.2e-122 hypothetical protein D910_12756 [Dendroctonus ponderosae] 807033242 XM_004529566.2 72 2.49629e-26 PREDICTED: Ceratitis capitata TM2 domain-containing protein almondex (LOC101449885), mRNA -- -- -- -- Q9U4H5 661 3.5e-67 TM2 domain-containing protein almondex OS=Drosophila melanogaster GN=amx PE=2 SV=1 PF05733//PF06743 Tenuivirus/Phlebovirus nucleocapsid protein//FAST kinase-like protein, subdomain 1 -- -- GO:0003723//GO:0004672 RNA binding//protein kinase activity GO:0019013 viral nucleocapsid KOG4272 Predicted GTP-binding protein Cluster-8309.43507 BP_3 161.32 0.91 8807 642927636 XP_008195344.1 4414 0.0e+00 PREDICTED: zinc finger FYVE domain-containing protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19027 ZFYVE26 zinc finger FYVE domain-containing protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K19027 Q9VGP1 855 1.7e-89 Zinc finger FYVE domain-containing protein 26 homolog OS=Drosophila melanogaster GN=CG5270 PE=1 SV=3 PF01363//PF02419//PF04805 FYVE zinc finger//PsbL protein//E10-like protein conserved region GO:0015979//GO:0055114 photosynthesis//oxidation-reduction process GO:0046872//GO:0016972 metal ion binding//thiol oxidase activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.43508 BP_3 1150.84 20.49 2999 642933278 XP_008197355.1 1071 1.3e-113 PREDICTED: serine/threonine-protein kinase pakG isoform X2 [Tribolium castaneum] 817211936 XM_012426709.1 59 2.16216e-19 PREDICTED: Orussus abietinus uncharacterized LOC105700657 (LOC105700657), mRNA -- -- -- -- Q96NU1 194 2.6e-13 Sterile alpha motif domain-containing protein 11 OS=Homo sapiens GN=SAMD11 PE=2 SV=3 PF07647//PF00536//PF02198 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain -- -- GO:0005515//GO:0043565 protein binding//sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.43509 BP_3 451.27 7.42 3224 642921426 XP_008192862.1 1545 1.5e-168 PREDICTED: kelch domain-containing protein 3 [Tribolium castaneum]>gi|270006295|gb|EFA02743.1| hypothetical protein TcasGA2_TC008474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYI2 940 8.6e-100 Kelch domain-containing protein 3 OS=Rattus norvegicus GN=Klhdc3 PE=2 SV=1 PF07646//PF03089//PF01344 Kelch motif//Recombination activating protein 2//Kelch motif GO:0006310 DNA recombination GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG0379 Kelch repeat-containing proteins Cluster-8309.43510 BP_3 79.12 3.50 1382 91093162 XP_967461.1 1374 4.3e-149 PREDICTED: nucleolar complex protein 4 homolog B [Tribolium castaneum]>gi|270012948|gb|EFA09396.1| hypothetical protein TcasGA2_TC004314 [Tribolium castaneum] -- -- -- -- -- K14771 NOC4, UTP19 U3 small nucleolar RNA-associated protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K14771 Q6NU91 432 3.0e-41 Nucleolar complex protein 4 homolog B OS=Xenopus laevis GN=noc4l-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2154 Predicted nucleolar protein involved in ribosome biogenesis Cluster-8309.43511 BP_3 513.07 6.93 3859 270012327 EFA08775.1 2527 2.4e-282 hypothetical protein TcasGA2_TC006465 [Tribolium castaneum] 642932319 XM_008198841.1 537 0 PREDICTED: Tribolium castaneum myosin 15 (LOC658144), mRNA K10361 MYO15 myosin XV http://www.genome.jp/dbget-bin/www_bget?ko:K10361 Q9UKN7 699 9.1e-72 Unconventional myosin-XV OS=Homo sapiens GN=MYO15A PE=1 SV=2 PF01716//PF00784 Manganese-stabilising protein / photosystem II polypeptide//MyTH4 domain GO:0015979//GO:0042549 photosynthesis//photosystem II stabilization GO:0005509 calcium ion binding GO:0019898//GO:0005856//GO:0009654//GO:0009523 extrinsic component of membrane//cytoskeleton//photosystem II oxygen evolving complex//photosystem II KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.43512 BP_3 142.94 6.33 1381 189234402 XP_974971.2 196 1.7e-12 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43513 BP_3 87.76 0.93 4822 91087699 XP_974256.1 950 2.2e-99 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 518 1.1e-50 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852//PF01036 Glycosyltransferase family 10 (fucosyltransferase) C-term//Bacteriorhodopsin-like protein GO:0070085//GO:0006486 glycosylation//protein glycosylation GO:0016757//GO:0008417 transferase activity, transferring glycosyl groups//fucosyltransferase activity GO:0005794//GO:0016020 Golgi apparatus//membrane KOG2619 Fucosyltransferase Cluster-8309.43514 BP_3 371.48 6.36 3105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43517 BP_3 28.77 0.31 4720 642926118 XP_008194793.1 3828 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 32 isoform X1 [Tribolium castaneum] -- -- -- -- -- K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q8NFA0 1141 6.2e-123 Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens GN=USP32 PE=1 SV=1 PF13499//PF06337//PF13405//PF00036//PF00443//PF11421 EF-hand domain pair//DUSP domain//EF-hand domain//EF hand//Ubiquitin carboxyl-terminal hydrolase//ATP synthase F1 beta subunit GO:0006754//GO:0016579//GO:0006508 ATP biosynthetic process//protein deubiquitination//proteolysis GO:0005509//GO:0016887//GO:0036459//GO:0005524//GO:0004843 calcium ion binding//ATPase activity//ubiquitinyl hydrolase activity//ATP binding//ubiquitin-specific protease activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.43518 BP_3 27.71 0.80 1970 546676863 ERL87800.1 503 6.0e-48 hypothetical protein D910_05189, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43520 BP_3 191.70 3.27 3116 524899886 XP_005106369.1 502 1.2e-47 PREDICTED: E3 ubiquitin-protein ligase mind-bomb-like isoform X1 [Aplysia californica] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 313 4.2e-27 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF14634//PF00097//PF00569//PF15898//PF06701//PF13639//PF07663 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc finger, ZZ type//cGMP-dependent protein kinase interacting domain//Mib_herc2//Ring finger domain//Sorbitol phosphotransferase enzyme II C-terminus GO:0008643//GO:0009401//GO:0016567 carbohydrate transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//protein ubiquitination GO:0046872//GO:0008982//GO:0019901//GO:0008270//GO:0005515//GO:0004842 metal ion binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase binding//zinc ion binding//protein binding//ubiquitin-protein transferase activity GO:0009357//GO:0016021 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger Cluster-8309.43521 BP_3 807.75 8.29 4988 478250812 ENN71304.1 2974 0.0e+00 hypothetical protein YQE_12229, partial [Dendroctonus ponderosae] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 1642 5.3e-181 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 PF00050//PF00093//PF05375//PF07648//PF02130//PF04584 Kazal-type serine protease inhibitor domain//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII)//Kazal-type serine protease inhibitor domain//Uncharacterized protein family UPF0054//Poxvirus A28 family GO:0016032//GO:0006364 viral process//rRNA processing GO:0004222//GO:0030414//GO:0005515 metalloendopeptidase activity//peptidase inhibitor activity//protein binding GO:0019031 viral envelope -- -- Cluster-8309.43524 BP_3 61.00 1.68 2043 478255783 ENN75992.1 1775 2.0e-195 hypothetical protein YQE_07524, partial [Dendroctonus ponderosae]>gi|546680369|gb|ERL90648.1| hypothetical protein D910_07995 [Dendroctonus ponderosae] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P09242 902 1.4e-95 Alkaline phosphatase, tissue-nonspecific isozyme OS=Mus musculus GN=Alpl PE=1 SV=2 PF00245//PF01663//PF01676//PF00884 Alkaline phosphatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Metalloenzyme superfamily//Sulfatase GO:0008152 metabolic process GO:0046872//GO:0016791//GO:0003824//GO:0008484 metal ion binding//phosphatase activity//catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.43528 BP_3 254.11 1.46 8665 642939376 XP_008193155.1 2929 0.0e+00 PREDICTED: uncharacterized protein LOC660515 isoform X1 [Tribolium castaneum] 642939377 XM_008194938.1 113 6.03246e-49 PREDICTED: Tribolium castaneum hemicentin-1 (LOC660515), transcript variant X2, mRNA -- -- -- -- Q8WZ42 332 7.4e-29 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF00895//PF05510//PF06377//PF13895 ATP synthase protein 8//Sarcoglycan alpha/epsilon//Adipokinetic hormone//Immunoglobulin domain GO:0015986//GO:0015992//GO:0007165 ATP synthesis coupled proton transport//proton transport//signal transduction GO:0015078//GO:0005179//GO:0005515 hydrogen ion transmembrane transporter activity//hormone activity//protein binding GO:0000276//GO:0016012 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//sarcoglycan complex -- -- Cluster-8309.43529 BP_3 290.11 2.34 6265 373159261 AEY63780.1 2465 6.0e-275 ecdysone receptor isoform A [Monochamus alternatus] 373159260 JN616374.1 1387 0 Monochamus alternatus ecdysone receptor isoform A mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 P49880 1354 1.7e-147 Ecdysone receptor OS=Aedes aegypti GN=EcR PE=1 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.43530 BP_3 2597.54 27.45 4853 282400162 NP_001164204.1 2375 1.3e-264 hexamerin 5 precursor [Tribolium castaneum]>gi|270012805|gb|EFA09253.1| hypothetical protein TcasGA2_TC006515 [Tribolium castaneum] 157137263 XM_001663913.1 48 4.57929e-13 Aedes aegypti AAEL013757-RA mRNA K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 Q17127 1337 1.2e-145 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 PF06951 Group XII secretory phospholipase A2 precursor (PLA2G12) GO:0009395//GO:0016042 phospholipid catabolic process//lipid catabolic process GO:0005509//GO:0004623 calcium ion binding//phospholipase A2 activity GO:0005576 extracellular region -- -- Cluster-8309.43531 BP_3 117.39 11.22 796 270002887 EEZ99334.1 630 4.6e-63 hypothetical protein TcasGA2_TC004551 [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q01603 393 5.7e-37 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.43534 BP_3 867.07 9.27 4798 91084515 XP_967225.1 790 7.7e-81 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.43535 BP_3 167.28 2.35 3720 642939887 XP_008200200.1 3339 0.0e+00 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12616 EDC4 enhancer of mRNA-decapping protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12616 Q1LUT1 643 2.7e-65 Enhancer of mRNA-decapping protein 4 OS=Danio rerio GN=edc4 PE=3 SV=1 PF01442//PF06152//PF08236//PF03127 Apolipoprotein A1/A4/E domain//Phage minor capsid protein 2//SRI (Set2 Rpb1 interacting) domain//GAT domain GO:0006886//GO:0034968//GO:0006869//GO:0042157//GO:0006554//GO:0006479//GO:0006355 intracellular protein transport//histone lysine methylation//lipid transport//lipoprotein metabolic process//lysine catabolic process//protein methylation//regulation of transcription, DNA-templated GO:0005198//GO:0018024//GO:0008289 structural molecule activity//histone-lysine N-methyltransferase activity//lipid binding GO:0019028//GO:0005622//GO:0005694//GO:0005576 viral capsid//intracellular//chromosome//extracellular region KOG1916 Nuclear protein, contains WD40 repeats Cluster-8309.43539 BP_3 307.99 19.20 1065 478257747 ENN77890.1 970 2.3e-102 hypothetical protein YQE_05567, partial [Dendroctonus ponderosae]>gi|546677670|gb|ERL88464.1| hypothetical protein D910_05850 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05946 610 5.2e-62 Sarcoplasmic calcium-binding protein 1 OS=Astacus leptodactylus PE=1 SV=1 PF00036//PF13833//PF13405//PF13499//PF13202//PF09298 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Fumarylacetoacetase N-terminal GO:0042207//GO:0006570//GO:0009072 styrene catabolic process//tyrosine metabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0005509 fumarylacetoacetase activity//calcium ion binding -- -- -- -- Cluster-8309.43540 BP_3 36.20 0.60 3176 91090890 XP_973414.1 3574 0.0e+00 PREDICTED: coatomer subunit gamma [Tribolium castaneum]>gi|270013230|gb|EFA09678.1| hypothetical protein TcasGA2_TC011806 [Tribolium castaneum] -- -- -- -- -- K17267 COPG coatomer protein complex, subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K17267 Q29AE5 2781 0.0e+00 Coatomer subunit gamma OS=Drosophila pseudoobscura pseudoobscura GN=gammaCop PE=3 SV=1 PF01602//PF08752//PF02985 Adaptin N terminal region//Coatomer gamma subunit appendage platform subdomain//HEAT repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030126//GO:0030117 COPI vesicle coat//membrane coat KOG1078 Vesicle coat complex COPI, gamma subunit Cluster-8309.43542 BP_3 3058.47 42.46 3764 642920169 XP_008192230.1 3419 0.0e+00 PREDICTED: echinoderm microtubule-associated protein-like 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18595 EML1_2 echinoderm microtubule-associated protein-like 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18595 Q4V8C3 1931 1.2e-214 Echinoderm microtubule-associated protein-like 1 OS=Rattus norvegicus GN=Eml1 PE=2 SV=2 PF00930//PF00400 Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains Cluster-8309.43543 BP_3 1327.73 36.75 2033 642936925 XP_008194485.1 1095 1.4e-116 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X2 [Tribolium castaneum] -- -- -- -- -- K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 264 1.3e-21 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF09494//PF00023//PF03776//PF13606 Slx4 endonuclease//Ankyrin repeat//Septum formation topological specificity factor MinE//Ankyrin repeat GO:0006281//GO:0051301//GO:0006260//GO:0006308//GO:0032955 DNA repair//cell division//DNA replication//DNA catabolic process//regulation of barrier septum assembly GO:0005515//GO:0017108 protein binding//5'-flap endonuclease activity GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex -- -- Cluster-8309.43545 BP_3 354.11 2.36 7524 189234456 XP_968035.2 3830 0.0e+00 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Tribolium castaneum]>gi|270001744|gb|EEZ98191.1| hypothetical protein TcasGA2_TC000620 [Tribolium castaneum] 831497549 XM_012853965.1 227 2.22147e-112 PREDICTED: Fundulus heteroclitus phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3), mRNA K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00914 Q6PF93 2695 6.3e-303 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Mus musculus GN=Pik3c3 PE=1 SV=1 PF00454 Phosphatidylinositol 3- and 4-kinase GO:0046854//GO:0048015//GO:0036092 phosphatidylinositol phosphorylation//phosphatidylinositol-mediated signaling//phosphatidylinositol-3-phosphate biosynthetic process GO:0016303//GO:0005524//GO:0016773 1-phosphatidylinositol-3-kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0906 Phosphatidylinositol 3-kinase VPS34, involved in signal transduction Cluster-8309.43549 BP_3 632.94 7.79 4207 478257812 ENN77955.1 359 6.4e-31 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0001522//GO:0042254//GO:0006464 pseudouridine synthesis//ribosome biogenesis//cellular protein modification process GO:0016151//GO:0030515 nickel cation binding//snoRNA binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.43550 BP_3 1220.09 8.63 7105 194880788 XP_001974544.1 2122 4.0e-235 GG21804 [Drosophila erecta]>gi|190657731|gb|EDV54944.1| GG21804 [Drosophila erecta] 572319027 XM_006625008.1 56 2.39887e-17 PREDICTED: Apis dorsata E3 ubiquitin-protein ligase SMURF1-like (LOC102679083), mRNA K04678 SMURF E3 ubiquitin ligase SMURF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K04678 A9JRZ0 1867 6.1e-207 E3 ubiquitin-protein ligase SMURF2 OS=Danio rerio GN=smurf2 PE=2 SV=1 PF00168//PF00397//PF00632 C2 domain//WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.43551 BP_3 106.00 2.79 2125 642927136 XP_972282.2 1355 1.0e-146 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0L6 377 1.1e-34 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Mus musculus GN=Paox PE=1 SV=3 PF00070//PF01134//PF05834//PF00732//PF01266//PF06389//PF12831//PF02254//PF01593//PF07992//PF01494 Pyridine nucleotide-disulphide oxidoreductase//Glucose inhibited division protein A//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase//Filovirus membrane-associated protein VP24//FAD dependent oxidoreductase//TrkA-N domain//Flavin containing amine oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain GO:0016117//GO:0055114//GO:0008033//GO:0016032//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//tRNA processing//viral process//potassium ion transport GO:0050660//GO:0016614//GO:0016705//GO:0071949//GO:0005198//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//structural molecule activity//oxidoreductase activity GO:0016020 membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.43553 BP_3 80.20 0.92 4475 642916588 XP_008191804.1 545 1.9e-52 PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum]>gi|642916590|ref|XP_008191810.1| PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12597 AIR1_2 protein AIR1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12597 A1L2T6 239 2.3e-18 Zinc finger CCHC domain-containing protein 7 OS=Xenopus laevis GN=zcchc7 PE=2 SV=2 PF06331 Transcription factor TFIIH complex subunit Tfb5 GO:0006289//GO:0006355 nucleotide-excision repair//regulation of transcription, DNA-templated -- -- GO:0000439 core TFIIH complex KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.43557 BP_3 267.18 5.06 2837 91078462 XP_967648.1 2187 4.7e-243 PREDICTED: protein SGT1 homolog ecdysoneless [Tribolium castaneum]>gi|270004999|gb|EFA01447.1| hypothetical protein TcasGA2_TC030757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W032 1156 6.8e-125 Protein ecdysoneless OS=Drosophila melanogaster GN=ecd PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2406 MADS box transcription factor Cluster-8309.43559 BP_3 267.49 10.45 1525 270003289 EEZ99736.1 1349 3.7e-146 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13678 128 5.9e-06 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF09202//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//Rio2, N-terminal//C2 domain GO:0035556//GO:0006468//GO:0009069//GO:0016310 intracellular signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0005515 ATP binding//protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.4356 BP_3 1.00 0.76 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43561 BP_3 488.43 6.46 3935 642927786 XP_008195405.1 2733 3.1e-306 PREDICTED: pre-mRNA-processing factor 39 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13217 PRPF39, PRP39 pre-mRNA-processing factor 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13217 Q1JPZ7 1242 1.0e-134 Pre-mRNA-processing factor 39 OS=Danio rerio GN=prpf39 PE=2 SV=2 PF02184//PF13181//PF13174//PF13414//PF05843 HAT (Half-A-TPR) repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Suppressor of forked protein (Suf) GO:0006396//GO:0006397 RNA processing//mRNA processing GO:0005515 protein binding GO:0005622//GO:0005634 intracellular//nucleus KOG1258 mRNA processing protein Cluster-8309.43563 BP_3 127.73 1.49 4419 642927788 XP_008195406.1 2047 1.2e-226 PREDICTED: pre-mRNA-processing factor 39 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13217 PRPF39, PRP39 pre-mRNA-processing factor 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13217 Q1JPZ7 1005 3.4e-107 Pre-mRNA-processing factor 39 OS=Danio rerio GN=prpf39 PE=2 SV=2 PF13181//PF00515//PF02184//PF13414//PF02978//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//HAT (Half-A-TPR) repeat//TPR repeat//Signal peptide binding domain//Tetratricopeptide repeat GO:0006614//GO:0006396 SRP-dependent cotranslational protein targeting to membrane//RNA processing GO:0008312//GO:0005515 7S RNA binding//protein binding GO:0005622//GO:0048500 intracellular//signal recognition particle KOG1258 mRNA processing protein Cluster-8309.43565 BP_3 115.54 3.68 1806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43566 BP_3 179.73 2.41 3886 546685110 ERL94637.1 1750 3.0e-192 hypothetical protein D910_11912 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PCB5 1066 2.6e-114 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 PF06151 Trehalose receptor GO:0007607//GO:0050912//GO:0007187 obsolete taste perception//detection of chemical stimulus involved in sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4425 Uncharacterized conserved protein Cluster-8309.43569 BP_3 1851.73 32.73 3019 91086463 XP_969857.1 1953 6.7e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1237 2.9e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.43571 BP_3 74.31 0.66 5691 189240823 XP_001811917.1 3289 0.0e+00 PREDICTED: ATP-dependent RNA helicase SUV3 homolog, mitochondrial [Tribolium castaneum]>gi|270013711|gb|EFA10159.1| hypothetical protein TcasGA2_TC012348 [Tribolium castaneum] 755880618 XM_005185469.2 352 0 PREDICTED: Musca domestica ATP-dependent RNA helicase SUV3 homolog, mitochondrial (LOC101900390), mRNA K17675 SUPV3L1, SUV3 ATP-dependent RNA helicase SUPV3L1/SUV3 http://www.genome.jp/dbget-bin/www_bget?ko:K17675 Q9VN03 2699 1.6e-303 ATP-dependent RNA helicase SUV3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG9791 PE=2 SV=3 PF12513//PF11965//PF00001 Mitochondrial degradasome RNA helicase subunit C terminal//Domain of unknown function (DUF3479)//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0015994 G-protein coupled receptor signaling pathway//chlorophyll metabolic process GO:0003676//GO:0016851//GO:0016817//GO:0005524//GO:0004386//GO:0004930 nucleic acid binding//magnesium chelatase activity//hydrolase activity, acting on acid anhydrides//ATP binding//helicase activity//G-protein coupled receptor activity GO:0016021//GO:0010007 integral component of membrane//magnesium chelatase complex KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily Cluster-8309.43573 BP_3 473.26 7.17 3475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05241 Emopamil binding protein GO:0006694//GO:0016125 steroid biosynthetic process//sterol metabolic process GO:0047750 cholestenol delta-isomerase activity GO:0016021 integral component of membrane -- -- Cluster-8309.43580 BP_3 15.16 0.38 2237 157128008 XP_001661271.1 710 6.8e-72 AAEL010985-PA [Aedes aegypti]>gi|108872753|gb|EAT36978.1| AAEL010985-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03523 Macrophage scavenger receptor GO:0007165//GO:0006898 signal transduction//receptor-mediated endocytosis GO:0005044 scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.43581 BP_3 2.03 0.48 495 817215882 XP_012284038.1 341 9.3e-30 PREDICTED: nuclear transcription factor Y subunit B-1 [Orussus abietinus]>gi|817215884|ref|XP_012284039.1| PREDICTED: nuclear transcription factor Y subunit B-1 [Orussus abietinus] -- -- -- -- -- K08065 NFYB nuclear transcription Y subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K08065 P63140 320 1.0e-28 Nuclear transcription factor Y subunit beta OS=Rattus norvegicus GN=Nfyb PE=1 SV=1 PF00125//PF02269 Core histone H2A/H2B/H3/H4//Transcription initiation factor IID, 18kD subunit GO:0006366 transcription from RNA polymerase II promoter GO:0003677 DNA binding -- -- KOG0869 CCAAT-binding factor, subunit A (HAP3) Cluster-8309.43582 BP_3 98.64 1.09 4658 270017210 EFA13656.1 560 3.5e-54 hypothetical protein TcasGA2_TC016129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YMJ7 216 1.1e-15 Envelope fusion protein OS=Lymantria dispar multicapsid nuclear polyhedrosis virus GN=LdOrf-130 PE=3 SV=1 PF07651//PF06009//PF03632//PF02601 ANTH domain//Laminin Domain II//Glycosyl hydrolase family 65 central catalytic domain//Exonuclease VII, large subunit GO:0007155//GO:0005975//GO:0006308 cell adhesion//carbohydrate metabolic process//DNA catabolic process GO:0003824//GO:0008855//GO:0005543 catalytic activity//exodeoxyribonuclease VII activity//phospholipid binding GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.43586 BP_3 1100.07 12.75 4450 91081213 XP_975619.1 894 6.3e-93 PREDICTED: proto-oncogene c-Fos isoform X2 [Tribolium castaneum]>gi|270006054|gb|EFA02502.1| hypothetical protein TcasGA2_TC008201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.43587 BP_3 61.31 0.38 8082 533200262 XP_005412710.1 597 3.1e-58 PREDICTED: zinc finger protein 347-like isoform X2 [Chinchilla lanigera] 642926231 XM_008196617.1 95 5.705e-39 PREDICTED: Tribolium castaneum transcriptional activator protein Pur-alpha (LOC662482), transcript variant X2, mRNA -- -- -- -- A6NK75 565 6.6e-56 Zinc finger protein 98 OS=Homo sapiens GN=ZNF98 PE=2 SV=4 PF13912//PF16622//PF03248//PF00096//PF13465 C2H2-type zinc finger//zinc-finger C2H2-type//Rer1 family//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.43588 BP_3 541.40 7.82 3630 270011110 EFA07558.1 1124 1.1e-119 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 764 2.5e-79 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF08367//PF02949//PF08395//PF00089//PF04130 Peptidase M16C associated//7tm Odorant receptor//7tm Chemosensory receptor//Trypsin//Spc97 / Spc98 family GO:0007187//GO:0007608//GO:0050909//GO:0006508//GO:0000226//GO:0090063 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell//sensory perception of taste//proteolysis//microtubule cytoskeleton organization//positive regulation of microtubule nucleation GO:0005549//GO:0004984//GO:0004252 odorant binding//olfactory receptor activity//serine-type endopeptidase activity GO:0005815//GO:0016021//GO:0000922//GO:0016020 microtubule organizing center//integral component of membrane//spindle pole//membrane -- -- Cluster-8309.43589 BP_3 759.83 3.58 10518 91077334 XP_974850.1 2102 1.2e-232 PREDICTED: amidophosphoribosyltransferase [Tribolium castaneum]>gi|270001665|gb|EEZ98112.1| hypothetical protein TcasGA2_TC000530 [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1736 1.4e-191 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF07851//PF04632//PF04508//PF04728//PF01401//PF00038//PF05404//PF11380//PF04111//PF13405//PF02465//PF01166//PF10473//PF00156//PF00769//PF17060 TMPIT-like protein//Fusaric acid resistance protein family//Viral A-type inclusion protein repeat//Lipoprotein leucine-zipper//Angiotensin-converting enzyme//Intermediate filament protein//Translocon-associated protein, delta subunit precursor (TRAP-delta)//Stealth protein CR2, conserved region 2//Autophagy protein Apg6//EF-hand domain//Flagellar hook-associated protein 2 N-terminus//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Phosphoribosyl transferase domain//Ezrin/radixin/moesin family//Monopolar spindle protein 2 GO:0030474//GO:0016032//GO:0006508//GO:0006144//GO:0071988//GO:0006914//GO:0006536//GO:0009113//GO:0006810//GO:0006189//GO:0006541//GO:0006355//GO:0009116 spindle pole body duplication//viral process//proteolysis//purine nucleobase metabolic process//protein localization to spindle pole body//autophagy//glutamate metabolic process//purine nucleobase biosynthetic process//transport//'de novo' IMP biosynthetic process//glutamine metabolic process//regulation of transcription, DNA-templated//nucleoside metabolic process GO:0008092//GO:0046872//GO:0005509//GO:0008237//GO:0008134//GO:0045502//GO:0008241//GO:0004044//GO:0003700//GO:0016772//GO:0042803//GO:0005198//GO:0051536 cytoskeletal protein binding//metal ion binding//calcium ion binding//metallopeptidase activity//transcription factor binding//dynein binding//peptidyl-dipeptidase activity//amidophosphoribosyltransferase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring phosphorus-containing groups//protein homodimerization activity//structural molecule activity//iron-sulfur cluster binding GO:0005667//GO:0030286//GO:0009424//GO:0005882//GO:0019898//GO:0005783//GO:0019867//GO:0005886//GO:0016020//GO:0016021//GO:0005737 transcription factor complex//dynein complex//bacterial-type flagellum hook//intermediate filament//extrinsic component of membrane//endoplasmic reticulum//outer membrane//plasma membrane//membrane//integral component of membrane//cytoplasm KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.43591 BP_3 25.11 5.92 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43592 BP_3 44.40 0.89 2688 546678697 ERL89265.1 1371 1.8e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 3.4e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.43593 BP_3 190.00 8.93 1317 642929245 XP_008195751.1 329 6.1e-28 PREDICTED: poly [ADP-ribose] polymerase 11-like [Tribolium castaneum]>gi|270009669|gb|EFA06117.1| hypothetical protein TcasGA2_TC008960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2W4 186 9.5e-13 Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens GN=ZC3HAV1 PE=1 SV=3 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- -- -- Cluster-8309.43594 BP_3 563.55 3.19 8807 642926988 XP_008195092.1 1922 7.7e-212 PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum]>gi|642926990|ref|XP_008195093.1| PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum] 642926985 XM_008196869.1 122 6.08852e-54 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX27 (LOC103313489), mRNA K01320 F7 coagulation factor VII http://www.genome.jp/dbget-bin/www_bget?ko:K01320 P21902 337 2.0e-29 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF02468 Trypsin//Photosystem II reaction centre N protein (psbN) GO:0015979//GO:0006508 photosynthesis//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.43595 BP_3 490.01 7.12 3611 642920655 XP_008192506.1 3040 0.0e+00 PREDICTED: tetratricopeptide repeat protein 17 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E9PVB5 637 1.3e-64 Tetratricopeptide repeat protein 17 OS=Mus musculus GN=Ttc17 PE=2 SV=1 PF13181//PF08152//PF02468//PF13174//PF00515//PF13374//PF13371//PF13176//PF13414 Tetratricopeptide repeat//GUCT (NUC152) domain//Photosystem II reaction centre N protein (psbN)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0015979 photosynthesis GO:0005515//GO:0003723//GO:0004386//GO:0005524 protein binding//RNA binding//helicase activity//ATP binding GO:0005634//GO:0009539//GO:0009523//GO:0016020 nucleus//photosystem II reaction center//photosystem II//membrane KOG4507 Uncharacterized conserved protein, contains TPR repeats Cluster-8309.43597 BP_3 1065.42 13.26 4163 642913615 XP_008201089.1 4124 0.0e+00 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X4 [Tribolium castaneum]>gi|270002050|gb|EEZ98497.1| hypothetical protein TcasGA2_TC000997 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q5PQN1 2385 3.1e-267 Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0941 E3 ubiquitin protein ligase Cluster-8309.436 BP_3 8.00 0.60 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43602 BP_3 377.18 3.57 5383 270010529 EFA06977.1 2726 2.8e-305 hypothetical protein TcasGA2_TC009937 [Tribolium castaneum] 642929423 XM_008197612.1 391 0 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X2, mRNA -- -- -- -- Q9UIF8 496 4.4e-48 Bromodomain adjacent to zinc finger domain protein 2B OS=Homo sapiens GN=BAZ2B PE=1 SV=3 PF16866//PF13718//PF00628//PF01221//PF08926//PF00130//PF00439 PHD-finger//GNAT acetyltransferase 2//PHD-finger//Dynein light chain type 1//Domain of unknown function (DUF1908)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain GO:0009069//GO:0006468//GO:0042967//GO:0016310//GO:0035556//GO:0007017 serine family amino acid metabolic process//protein phosphorylation//acyl-carrier-protein biosynthetic process//phosphorylation//intracellular signal transduction//microtubule-based process GO:0008080//GO:0005515//GO:0005524//GO:0000287//GO:0004674 N-acetyltransferase activity//protein binding//ATP binding//magnesium ion binding//protein serine/threonine kinase activity GO:0005875 microtubule associated complex KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.43604 BP_3 89.90 0.88 5226 642914074 XP_008201534.1 354 3.0e-30 PREDICTED: uncharacterized protein LOC658486 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43607 BP_3 1009.00 22.13 2489 332375116 AEE62699.1 2526 2.0e-282 unknown [Dendroctonus ponderosae]>gi|546676201|gb|ERL87268.1| hypothetical protein D910_04664 [Dendroctonus ponderosae] -- -- -- -- -- K12825 SF3A1, SAP114 splicing factor 3A subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12825 Q15459 1472 1.4e-161 Splicing factor 3A subunit 1 OS=Homo sapiens GN=SF3A1 PE=1 SV=1 PF01805//PF01093//PF00240 Surp module//Clusterin//Ubiquitin family GO:0008219//GO:0006396 cell death//RNA processing GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.43610 BP_3 680.00 16.15 2321 91091438 XP_972410.1 2336 2.0e-260 PREDICTED: protein ST7 homolog [Tribolium castaneum]>gi|270000957|gb|EEZ97404.1| hypothetical protein TcasGA2_TC011233 [Tribolium castaneum] 759067333 XM_011344833.1 251 3.09141e-126 PREDICTED: Cerapachys biroi protein ST7 homolog (LOC105282664), mRNA -- -- -- -- Q9VPB1 2095 7.3e-234 Protein ST7 homolog OS=Drosophila melanogaster GN=CG3634 PE=2 SV=1 PF13181//PF00515//PF00637//PF13174//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Region in Clathrin and VPS//Tetratricopeptide repeat//TPR repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding -- -- KOG3807 Predicted membrane protein ST7 (tumor suppressor in humans) Cluster-8309.43611 BP_3 6.00 1.11 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43613 BP_3 48.05 0.64 3907 642934754 XP_967096.2 1782 5.9e-196 PREDICTED: sorting nexin-30 [Tribolium castaneum] 642934008 XM_008199379.1 181 4.28107e-87 PREDICTED: Tribolium castaneum interferon-related developmental regulator 2 (LOC662460), mRNA K17921 SNX7_30 sorting nexin-7/30 http://www.genome.jp/dbget-bin/www_bget?ko:K17921 Q12894 597 6.2e-60 Interferon-related developmental regulator 2 OS=Homo sapiens GN=IFRD2 PE=1 SV=3 PF00787//PF02985//PF03114 PX domain//HEAT repeat//BAR domain -- -- GO:0035091//GO:0005515 phosphatidylinositol binding//protein binding GO:0005737 cytoplasm KOG2842 Interferon-related protein PC4 like Cluster-8309.43614 BP_3 1511.07 16.67 4660 642933926 XP_008197570.1 2887 0.0e+00 PREDICTED: protein Skeletor, isoforms B/C isoform X2 [Tribolium castaneum] 642933925 XM_008199348.1 442 0 PREDICTED: Tribolium castaneum protein Skeletor, isoforms B/C (LOC661990), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 894 2.7e-94 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.43615 BP_3 478.07 20.46 1418 642920923 XP_008192617.1 1088 6.4e-116 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P45376 573 1.4e-57 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.43618 BP_3 2.00 0.77 416 835482914 AKM70276.1 163 3.4e-09 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43620 BP_3 281.69 2.33 6117 91080927 XP_974039.1 6563 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3110 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF02617//PF01599//PF04183//PF02207 ATP-dependent Clp protease adaptor protein ClpS//Ribosomal protein S27a//IucA / IucC family//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0016567//GO:0030163//GO:0042254//GO:0006826//GO:0019290 translation//protein ubiquitination//protein catabolic process//ribosome biogenesis//iron ion transport//siderophore biosynthetic process GO:0004842//GO:0003735//GO:0008270//GO:0015343 ubiquitin-protein transferase activity//structural constituent of ribosome//zinc ion binding//siderophore transmembrane transporter activity GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.43622 BP_3 2177.94 12.90 8427 642911986 XP_008199051.1 3925 0.0e+00 PREDICTED: uncharacterized protein LOC657912 isoform X4 [Tribolium castaneum] 642911985 XM_008200829.1 807 0 PREDICTED: Tribolium castaneum amyloid beta A4 precursor protein-binding family A member 1-like (LOC657912), transcript variant X4, mRNA K04531 APBA1, X11 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) http://www.genome.jp/dbget-bin/www_bget?ko:K04531 O17583 1393 6.7e-152 Protein lin-10 OS=Caenorhabditis elegans GN=lin-10 PE=1 SV=1 PF13180//PF05773//PF00595//PF00640//PF05743 PDZ domain//RWD domain//PDZ domain (Also known as DHR or GLGF)//Phosphotyrosine interaction domain (PTB/PID)//UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG3605 Beta amyloid precursor-binding protein Cluster-8309.43626 BP_3 2.00 13.56 254 260814526 XP_002601966.1 156 1.3e-08 hypothetical protein BRAFLDRAFT_228315 [Branchiostoma floridae]>gi|229287269|gb|EEN57978.1| hypothetical protein BRAFLDRAFT_228315, partial [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 -- -- -- -- PF01096//PF00096//PF13465//PF02150//PF07649//PF00643 Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit//C1-like domain//B-box zinc finger GO:0006206//GO:0055114//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0003676//GO:0047134//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//nucleic acid binding//protein-disulfide reductase activity//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005622//GO:0005730 intracellular//nucleolus -- -- Cluster-8309.43627 BP_3 127.58 5.29 1455 642926860 XP_971810.2 180 1.3e-10 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H4Z2 132 1.9e-06 Zinc finger protein 335 OS=Homo sapiens GN=ZNF335 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43629 BP_3 3.00 0.46 604 260823044 XP_002603993.1 167 1.7e-09 hypothetical protein BRAFLDRAFT_71718 [Branchiostoma floridae]>gi|229289318|gb|EEN60004.1| hypothetical protein BRAFLDRAFT_71718 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q8NEP9 124 6.7e-06 Zinc finger protein 555 OS=Homo sapiens GN=ZNF555 PE=1 SV=4 PF00096//PF13465//PF02150//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit//Zinc-finger associated domain (zf-AD) GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.43631 BP_3 19.00 9.33 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF04988//PF07649 Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//C1-like domain GO:0055114 oxidation-reduction process GO:0003677//GO:0047134//GO:0046872 DNA binding//protein-disulfide reductase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.43633 BP_3 66.91 0.80 4311 642939478 XP_008197026.1 1939 4.1e-214 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 680 1.6e-69 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF07690//PF07817 Major Facilitator Superfamily//GLE1-like protein GO:0055085//GO:0016973 transmembrane transport//poly(A)+ mRNA export from nucleus -- -- GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.43634 BP_3 415.11 4.79 4465 642924813 XP_008194051.1 3880 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X3 [Tribolium castaneum] 749755570 XM_011141969.1 132 8.4915e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.6e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 PF01092//PF00569 Ribosomal protein S6e//Zinc finger, ZZ type GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2372 Oxidation resistance protein Cluster-8309.43635 BP_3 721.36 6.36 5759 780110017 XP_011676369.1 240 5.5e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 207 1.5e-14 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF07776//PF13606//PF06213//PF01539 Ankyrin repeat//Zinc-finger associated domain (zf-AD)//Ankyrin repeat//Cobalamin biosynthesis protein CobT//Hepatitis C virus envelope glycoprotein E1 GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0019031//GO:0005634 viral envelope//nucleus KOG4177 Ankyrin Cluster-8309.43637 BP_3 54.00 0.98 2943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43638 BP_3 397.56 1.99 9906 478255274 ENN75503.1 1875 2.5e-206 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] 815822303 XM_012377001.1 72 4.27201e-26 PREDICTED: Linepithema humile DNA primase small subunit (LOC105678028), mRNA K02684 PRI1 DNA primase small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02684 Q24317 1060 3.2e-113 DNA primase small subunit OS=Drosophila melanogaster GN=DNApol-alpha50 PE=2 SV=2 PF00057//PF13180//PF00884//PF00595//PF01896 Low-density lipoprotein receptor domain class A//PDZ domain//Sulfatase//PDZ domain (Also known as DHR or GLGF)//Eukaryotic and archaeal DNA primase small subunit GO:0006351//GO:0008152//GO:0006269 transcription, DNA-templated//metabolic process//DNA replication, synthesis of RNA primer GO:0005515//GO:0003896//GO:0008484 protein binding//DNA primase activity//sulfuric ester hydrolase activity GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.4364 BP_3 18.00 0.48 2118 478249687 ENN70196.1 749 1.9e-76 hypothetical protein YQE_13076, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AZB8 330 3.1e-29 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF01609 Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-8309.43640 BP_3 48.57 0.41 6037 642922760 XP_008193313.1 2111 6.4e-234 PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X2 [Tribolium castaneum] 751220523 XM_011165095.1 223 2.98045e-110 PREDICTED: Solenopsis invicta RNA pseudouridylate synthase domain-containing protein 2-like (LOC105198399), transcript variant X3, mRNA -- -- -- -- Q8IZ73 906 1.4e-95 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF13895//PF00951//PF00849 Immunoglobulin domain//Arterivirus GL envelope glycoprotein//RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0005515//GO:0003723//GO:0009982 protein binding//RNA binding//pseudouridine synthase activity GO:0019031 viral envelope KOG1919 RNA pseudouridylate synthases Cluster-8309.43641 BP_3 59.85 0.47 6437 642922760 XP_008193313.1 2754 1.9e-308 PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X2 [Tribolium castaneum] 751220523 XM_011165095.1 223 3.17762e-110 PREDICTED: Solenopsis invicta RNA pseudouridylate synthase domain-containing protein 2-like (LOC105198399), transcript variant X3, mRNA -- -- -- -- Q8IZ73 1040 4.4e-111 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF13895//PF00951//PF00849 Immunoglobulin domain//Arterivirus GL envelope glycoprotein//RNA pseudouridylate synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982//GO:0005515 RNA binding//pseudouridine synthase activity//protein binding GO:0019031 viral envelope KOG1919 RNA pseudouridylate synthases Cluster-8309.43642 BP_3 1353.16 29.40 2510 91078722 XP_967156.1 3311 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 5 [Tribolium castaneum]>gi|270004088|gb|EFA00536.1| hypothetical protein TcasGA2_TC003401 [Tribolium castaneum] 642915936 XM_962063.2 359 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 5 (LOC655510), mRNA K11836 USP5_13, UBP14 ubiquitin carboxyl-terminal hydrolase 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K11836 P56399 2135 1.8e-238 Ubiquitin carboxyl-terminal hydrolase 5 OS=Mus musculus GN=Usp5 PE=1 SV=1 PF00443//PF02148 Ubiquitin carboxyl-terminal hydrolase//Zn-finger in ubiquitin-hydrolases and other protein GO:0016579//GO:0006508//GO:0006511 protein deubiquitination//proteolysis//ubiquitin-dependent protein catabolic process GO:0046872//GO:0008234//GO:0008270//GO:0004221//GO:0008242//GO:0036459 metal ion binding//cysteine-type peptidase activity//zinc ion binding//obsolete ubiquitin thiolesterase activity//omega peptidase activity//ubiquitinyl hydrolase activity -- -- KOG0944 Ubiquitin-specific protease UBP14 Cluster-8309.43643 BP_3 22.52 0.40 2978 91078722 XP_967156.1 2751 1.9e-308 PREDICTED: ubiquitin carboxyl-terminal hydrolase 5 [Tribolium castaneum]>gi|270004088|gb|EFA00536.1| hypothetical protein TcasGA2_TC003401 [Tribolium castaneum] 642915936 XM_962063.2 344 7.96473e-178 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 5 (LOC655510), mRNA K11836 USP5_13, UBP14 ubiquitin carboxyl-terminal hydrolase 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K11836 P45974 1809 1.4e-200 Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens GN=USP5 PE=1 SV=2 PF00443//PF03635//PF02845 Ubiquitin carboxyl-terminal hydrolase//Vacuolar protein sorting-associated protein 35//CUE domain GO:0006511//GO:0006508//GO:0042147//GO:0015031//GO:0016579 ubiquitin-dependent protein catabolic process//proteolysis//retrograde transport, endosome to Golgi//protein transport//protein deubiquitination GO:0036459//GO:0008242//GO:0005515//GO:0008234//GO:0008270//GO:0004221//GO:0008565//GO:0046872 ubiquitinyl hydrolase activity//omega peptidase activity//protein binding//cysteine-type peptidase activity//zinc ion binding//obsolete ubiquitin thiolesterase activity//protein transporter activity//metal ion binding GO:0030904 retromer complex KOG0944 Ubiquitin-specific protease UBP14 Cluster-8309.43644 BP_3 115.82 10.07 846 189241532 XP_969755.2 532 1.1e-51 PREDICTED: transmembrane emp24 domain-containing protein 3 [Tribolium castaneum]>gi|270001016|gb|EEZ97463.1| hypothetical protein TcasGA2_TC011294 [Tribolium castaneum] -- -- -- -- -- K14825 ERP2 protein ERP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14825 Q9Y3B3 388 2.3e-36 Transmembrane emp24 domain-containing protein 7 OS=Homo sapiens GN=TMED7 PE=1 SV=2 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1693 emp24/gp25L/p24 family of membrane trafficking proteins Cluster-8309.43645 BP_3 158.00 11.77 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43647 BP_3 56.00 0.41 6873 642924674 XP_008194391.1 1323 1.7e-142 PREDICTED: protein abrupt isoform X2 [Tribolium castaneum] 642924672 XM_969854.3 316 6.79686e-162 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X4, mRNA -- -- -- -- Q24174 657 1.2e-66 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF02892//PF13912//PF00651//PF04135//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//BTB/POZ domain//Nucleolar RNA-binding protein, Nop10p family//Zinc-finger double domain//Zinc finger, C2H2 type GO:0042254//GO:0001522 ribosome biogenesis//pseudouridine synthesis GO:0030515//GO:0003677//GO:0005515//GO:0046872 snoRNA binding//DNA binding//protein binding//metal ion binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.43649 BP_3 41.00 1.03 2214 91089979 XP_973921.1 1248 2.8e-134 PREDICTED: uncharacterized protein LOC662748 isoform X2 [Tribolium castaneum]>gi|270013543|gb|EFA09991.1| hypothetical protein TcasGA2_TC012158 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05191 Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017 adenylate kinase activity -- -- -- -- Cluster-8309.43650 BP_3 316.39 8.20 2151 189239736 XP_001809239.1 901 4.7e-94 PREDICTED: uncharacterized protein LOC100141683 [Tribolium castaneum]>gi|270011260|gb|EFA07708.1| hypothetical protein TcasGA2_TC002185 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43652 BP_3 290.60 5.59 2797 478252725 ENN73120.1 1649 1.1e-180 hypothetical protein YQE_10261, partial [Dendroctonus ponderosae] -- -- -- -- -- K18398 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18398 Q0VA77 603 9.0e-61 Bis(5'-adenosyl)-triphosphatase enpp4 OS=Xenopus tropicalis GN=enpp4 PE=2 SV=1 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase -- -- GO:0003824 catalytic activity -- -- KOG2645 Type I phosphodiesterase/nucleotide pyrophosphatase Cluster-8309.43653 BP_3 20.06 1.74 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43654 BP_3 541.82 4.35 6296 642919612 XP_008191939.1 1923 4.2e-212 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X4 [Tribolium castaneum] 642919611 XM_008193717.1 100 7.37479e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 5.3e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF02257//PF01388//PF12031 RFX DNA-binding domain//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518) GO:0006355//GO:0006338 regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex -- -- Cluster-8309.43656 BP_3 100.35 0.80 6373 91087271 XP_975540.1 2035 4.4e-225 PREDICTED: TLD domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJX5 624 7.5e-63 TLD domain-containing protein 1 OS=Gallus gallus GN=TLDC1 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2557 Uncharacterized conserved protein, contains TLDc domain Cluster-8309.43657 BP_3 127.49 2.32 2937 189238180 XP_973789.2 1698 2.4e-186 PREDICTED: uncharacterized protein LOC662609, partial [Tribolium castaneum] 194890120 XM_001977204.1 49 7.66783e-14 Drosophila erecta GG18353 (Dere\GG18353), mRNA -- -- -- -- Q5ND56 258 9.5e-21 Protein FAM57A OS=Mus musculus GN=Fam57a PE=3 SV=1 PF03798 TLC domain -- -- -- -- GO:0016021 integral component of membrane KOG4561 Uncharacterized conserved protein, contains TBC domain Cluster-8309.43659 BP_3 1917.81 38.79 2675 642923832 XP_008193898.1 2379 2.4e-265 PREDICTED: importin subunit alpha-4 [Tribolium castaneum] 170029938 XM_001842796.1 313 1.22201e-160 Culex quinquefasciatus importin alpha, mRNA -- -- -- -- O35343 1914 8.2e-213 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 PF01602//PF11698//PF00514//PF01749//PF10508//PF02985 Adaptin N terminal region//V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Importin beta binding domain//Proteasome non-ATPase 26S subunit//HEAT repeat GO:0015031//GO:0043248//GO:0006606//GO:0016192//GO:0015991//GO:0006886 protein transport//proteasome assembly//protein import into nucleus//vesicle-mediated transport//ATP hydrolysis coupled proton transport//intracellular protein transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0005737//GO:0000221//GO:0005634 membrane coat//cytoplasm//vacuolar proton-transporting V-type ATPase, V1 domain//nucleus KOG0166 Karyopherin (importin) alpha Cluster-8309.4366 BP_3 4.00 0.46 713 391339732 XP_003744201.1 333 1.1e-28 PREDICTED: uncharacterized protein LOC100902024 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- Q8BHG9 127 3.6e-06 CGG triplet repeat-binding protein 1 OS=Mus musculus GN=Cggbp1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43660 BP_3 71.90 0.72 5074 642936719 XP_008198552.1 2792 0.0e+00 PREDICTED: ATP-dependent RNA helicase DDX54 [Tribolium castaneum]>gi|270000966|gb|EEZ97413.1| hypothetical protein TcasGA2_TC011242 [Tribolium castaneum] 642936718 XM_008200330.1 214 2.51993e-105 PREDICTED: Tribolium castaneum ATP-dependent RNA helicase DDX54 (LOC660698), mRNA K14808 DDX54, DBP10 ATP-dependent RNA helicase DDX54/DBP10 http://www.genome.jp/dbget-bin/www_bget?ko:K14808 Q8K4L0 1764 3.8e-195 ATP-dependent RNA helicase DDX54 OS=Mus musculus GN=Ddx54 PE=1 SV=1 PF00974//PF00270//PF00227//PF15785//PF08147 Rhabdovirus spike glycoprotein//DEAD/DEAH box helicase//Proteasome subunit//Serine/threonine-protein kinase smg-1//DBP10CT (NUC160) domain GO:0009069//GO:0016310//GO:0000184//GO:0051603 serine family amino acid metabolic process//phosphorylation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//proteolysis involved in cellular protein catabolic process GO:0008026//GO:0003723//GO:0005524//GO:0004298//GO:0016818//GO:0004674//GO:0003676 ATP-dependent helicase activity//RNA binding//ATP binding//threonine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//protein serine/threonine kinase activity//nucleic acid binding GO:0019031//GO:0005634//GO:0005839 viral envelope//nucleus//proteasome core complex KOG0337 ATP-dependent RNA helicase Cluster-8309.43663 BP_3 178.84 2.52 3717 642937806 XP_008200308.1 1035 2.3e-109 PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937808|ref|XP_008200309.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937810|ref|XP_008200310.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51884 137 1.3e-06 Lumican OS=Homo sapiens GN=LUM PE=1 SV=2 PF00560//PF13855//PF13516 Leucine Rich Repeat//Leucine rich repeat//Leucine Rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.43664 BP_3 906.16 18.35 2672 642937806 XP_008200308.1 1035 1.7e-109 PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937808|ref|XP_008200309.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937810|ref|XP_008200310.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51884 137 9.3e-07 Lumican OS=Homo sapiens GN=LUM PE=1 SV=2 PF00560//PF13516//PF13855 Leucine Rich Repeat//Leucine Rich repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.43665 BP_3 48.01 0.57 4353 642937806 XP_008200308.1 1035 2.7e-109 PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937808|ref|XP_008200309.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937810|ref|XP_008200310.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51884 137 1.5e-06 Lumican OS=Homo sapiens GN=LUM PE=1 SV=2 PF00560//PF13516//PF13855 Leucine Rich Repeat//Leucine Rich repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.43666 BP_3 678.44 6.85 5067 642911723 XP_008200714.1 359 7.8e-31 PREDICTED: scaffold attachment factor B2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80YR5 202 5.1e-14 Scaffold attachment factor B2 OS=Mus musculus GN=Safb2 PE=2 SV=2 PF06459//PF09270//PF04111//PF00076//PF02932 Ryanodine Receptor TM 4-6//Beta-trefoil DNA-binding domain//Autophagy protein Apg6//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Neurotransmitter-gated ion-channel transmembrane region GO:0006914//GO:0006816//GO:0006874//GO:0006811//GO:0006355 autophagy//calcium ion transport//cellular calcium ion homeostasis//ion transport//regulation of transcription, DNA-templated GO:0005219//GO:0000978//GO:0000982//GO:0003676 ryanodine-sensitive calcium-release channel activity//RNA polymerase II core promoter proximal region sequence-specific DNA binding//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//nucleic acid binding GO:0016021//GO:0005634//GO:0016020//GO:0005622 integral component of membrane//nucleus//membrane//intracellular -- -- Cluster-8309.43667 BP_3 97.27 4.75 1278 478257400 ENN77556.1 280 2.8e-22 hypothetical protein YQE_05852, partial [Dendroctonus ponderosae]>gi|546677756|gb|ERL88535.1| hypothetical protein D910_05920 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q95RI5 224 3.6e-17 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43669 BP_3 117.87 1.48 4125 820805580 AKG92781.1 3171 0.0e+00 trachealess [Leptinotarsa decemlineata] 820805579 KP147944.1 572 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1104 1.1e-118 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF08447//PF00010//PF04551//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold GO:0016114//GO:0055114//GO:0006355 terpenoid biosynthetic process//oxidation-reduction process//regulation of transcription, DNA-templated GO:0046983//GO:0005515//GO:0046429 protein dimerization activity//protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity -- -- -- -- Cluster-8309.4367 BP_3 6.20 0.32 1239 339258776 XP_003369574.1 502 5.0e-48 conserved hypothetical protein [Trichinella spiralis]>gi|316966176|gb|EFV50790.1| conserved hypothetical protein [Trichinella spiralis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43671 BP_3 48.25 1.17 2275 642924692 XP_008194400.1 1010 1.1e-106 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 255 1.6e-20 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.43672 BP_3 32.00 1.43 1367 91087851 XP_968461.1 1418 3.3e-154 PREDICTED: D-arabinitol dehydrogenase 1 [Tribolium castaneum]>gi|270012005|gb|EFA08453.1| hypothetical protein TcasGA2_TC006100 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R0J7 383 1.4e-35 D-arabinitol dehydrogenase 1 OS=Uromyces fabae GN=ARD1 PE=1 SV=1 PF08240//PF02558//PF00107 Alcohol dehydrogenase GroES-like domain//Ketopantoate reductase PanE/ApbA//Zinc-binding dehydrogenase GO:0015940//GO:0055114 pantothenate biosynthetic process//oxidation-reduction process GO:0008677//GO:0008270//GO:0000166//GO:0046872//GO:0016491 2-dehydropantoate 2-reductase activity//zinc ion binding//nucleotide binding//metal ion binding//oxidoreductase activity -- -- KOG0024 Sorbitol dehydrogenase Cluster-8309.43675 BP_3 602.66 4.24 7140 642939442 XP_008200393.1 3574 0.0e+00 PREDICTED: maternal protein pumilio isoform X6 [Tribolium castaneum] 642939433 XM_008202167.1 727 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.8e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF00806//PF08144 Pumilio-family RNA binding repeat//CPL (NUC119) domain -- -- GO:0003723 RNA binding -- -- KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.43676 BP_3 1116.00 17.20 3419 642938912 XP_008195563.1 4292 0.0e+00 PREDICTED: valine--tRNA ligase [Tribolium castaneum]>gi|270016168|gb|EFA12616.1| hypothetical protein TcasGA2_TC006857 [Tribolium castaneum] 780637039 XM_011688674.1 185 2.23585e-89 PREDICTED: Wasmannia auropunctata valine--tRNA ligase (LOC105449436), transcript variant X2, mRNA K01873 VARS, valS valyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01873 P49696 3306 0.0e+00 Valine--tRNA ligase OS=Takifugu rubripes GN=vars PE=3 SV=1 PF13603//PF09334//PF00133//PF08264//PF10458 Leucyl-tRNA synthetase, Domain 2//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA//Valyl tRNA synthetase tRNA binding arm GO:0009098//GO:0009097//GO:0006438//GO:0006450//GO:0009099//GO:0006418 leucine biosynthetic process//isoleucine biosynthetic process//valyl-tRNA aminoacylation//regulation of translational fidelity//valine biosynthetic process//tRNA aminoacylation for protein translation GO:0005524//GO:0004812//GO:0004832//GO:0002161//GO:0000166 ATP binding//aminoacyl-tRNA ligase activity//valine-tRNA ligase activity//aminoacyl-tRNA editing activity//nucleotide binding GO:0005737 cytoplasm KOG0432 Valyl-tRNA synthetase Cluster-8309.43679 BP_3 169.98 1.82 4784 478251175 ENN71651.1 1844 4.7e-203 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2N4 902 3.3e-95 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.4368 BP_3 2.97 0.77 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43681 BP_3 271.74 27.79 763 478257549 ENN77703.1 470 1.6e-44 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 166 1.1e-10 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- -- -- Cluster-8309.43682 BP_3 495.48 6.40 4025 642925010 XP_008194133.1 4674 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X3 [Tribolium castaneum] 759033712 XM_011331767.1 146 1.26179e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X1, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3842 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03540//PF03485//PF15014//PF05236//PF03293 Transcription initiation factor TFIID 23-30kDa subunit//Arginyl tRNA synthetase N terminal domain//Ceroid-lipofuscinosis neuronal protein 5//Transcription initiation factor TFIID component TAF4 family//Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006352//GO:0006206//GO:0006144//GO:0006560//GO:0006351//GO:0006420//GO:0022008//GO:0006525//GO:0019083 DNA-templated transcription, initiation//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//proline metabolic process//transcription, DNA-templated//arginyl-tRNA aminoacylation//neurogenesis//arginine metabolic process//viral transcription GO:0004814//GO:0003677//GO:0000166//GO:0005524//GO:0003899 arginine-tRNA ligase activity//DNA binding//nucleotide binding//ATP binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005669//GO:0005730//GO:0005737//GO:0005764 nucleus//transcription factor TFIID complex//nucleolus//cytoplasm//lysosome KOG3635 Phosphorylase kinase Cluster-8309.43685 BP_3 170.64 2.65 3394 166851820 NP_001107777.1 386 3.8e-34 pH-sensitive chloride channel precursor [Tribolium castaneum]>gi|642914731|ref|XP_008190329.1| PREDICTED: pH-sensitive chloride channel isoform X1 [Tribolium castaneum]>gi|156447623|gb|ABU63604.1| pH sensitive chloride channel [Tribolium castaneum]>gi|270002732|gb|EEZ99179.1| pHCl [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane -- -- Cluster-8309.43686 BP_3 200.64 1.02 9749 642914729 XP_008190327.1 1611 9.9e-176 PREDICTED: pH-sensitive chloride channel isoform X8 [Tribolium castaneum] 642914730 XM_008192107.1 360 0 PREDICTED: Tribolium castaneum pH sensitive chloride channel (Phcl), transcript variant X8, mRNA -- -- -- -- Q94900 458 2.0e-43 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.43687 BP_3 3875.51 205.66 1200 642926449 XP_008191964.1 927 2.5e-97 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|642926451|ref|XP_008191965.1| PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009087|gb|EFA05535.1| hypothetical protein TcasGA2_TC015722 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 537 1.7e-53 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF05834//PF07992//PF00732//PF02254 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0006813//GO:0055114 carotenoid biosynthetic process//potassium ion transport//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.43689 BP_3 25.00 0.81 1786 193785446 BAG54599.1 615 5.6e-61 unnamed protein product [Homo sapiens] 62865622 NM_004089.3 1786 0 Homo sapiens TSC22 domain family, member 3 (TSC22D3), transcript variant 2, mRNA -- -- -- -- Q5RED5 620 6.1e-63 TSC22 domain family protein 3 OS=Pongo abelii GN=TSC22D3 PE=2 SV=1 PF06005//PF01166//PF06156//PF04977//PF05531//PF01486//PF04799 Protein of unknown function (DUF904)//TSC-22/dip/bun family//Protein of unknown function (DUF972)//Septum formation initiator//Nucleopolyhedrovirus P10 protein//K-box region//fzo-like conserved region GO:0006260//GO:0006355//GO:0008053//GO:0043093//GO:0000917//GO:0007049 DNA replication//regulation of transcription, DNA-templated//mitochondrial fusion//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle GO:0003700//GO:0003924 transcription factor activity, sequence-specific DNA binding//GTPase activity GO:0005741//GO:0005737//GO:0016021//GO:0005634//GO:0019028//GO:0005667 mitochondrial outer membrane//cytoplasm//integral component of membrane//nucleus//viral capsid//transcription factor complex KOG4797 Transcriptional regulator Cluster-8309.43690 BP_3 1613.08 5.98 13303 642926407 XP_008191950.1 4370 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.22283e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.8e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF10541//PF00046//PF02121//PF03325//PF05920//PF03699//PF00529//PF02376 Nuclear envelope localisation domain//Homeobox domain//Phosphatidylinositol transfer protein//Herpesvirus polymerase accessory protein//Homeobox KN domain//Uncharacterised protein family (UPF0182)//HlyD membrane-fusion protein of T1SS//CUT domain GO:0019079//GO:0055085//GO:0006810//GO:0006355//GO:0006260 viral genome replication//transmembrane transport//transport//regulation of transcription, DNA-templated//DNA replication GO:0030337//GO:0003677 DNA polymerase processivity factor activity//DNA binding GO:0016021//GO:0042575//GO:0016020//GO:0005622 integral component of membrane//DNA polymerase complex//membrane//intracellular KOG3668 Phosphatidylinositol transfer protein Cluster-8309.43692 BP_3 145.70 1.95 3900 642935910 XP_008198225.1 1985 1.7e-219 PREDICTED: BMP-binding endothelial regulator protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8U9 950 7.2e-101 BMP-binding endothelial regulator protein OS=Homo sapiens GN=BMPER PE=1 SV=3 PF01479//PF00093 S4 domain//von Willebrand factor type C domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.43693 BP_3 86.66 0.59 7368 642911815 XP_008200755.1 3980 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 611 2.8e-61 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 PF01726 LexA DNA binding domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.43695 BP_3 357.58 14.19 1506 571330966 AHF27415.1 790 2.4e-81 putative sugar transporter 3_1 [Phaedon cochleariae]>gi|571330968|gb|AHF27416.1| putative sugar transporter 3_2 [Phaedon cochleariae] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 P58354 307 1.0e-26 Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus GN=SLC2A8 PE=2 SV=2 PF01769//PF00083//PF07690 Divalent cation transporter//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006812//GO:0055085 cation transport//transmembrane transport GO:0008324//GO:0022857 cation transmembrane transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.43696 BP_3 38.31 0.38 5190 347966510 XP_321327.5 384 1.0e-33 AGAP001756-PA [Anopheles gambiae str. PEST]>gi|333470028|gb|EAA01239.5| AGAP001756-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- Q8N4M1 290 3.3e-24 Choline transporter-like protein 3 OS=Homo sapiens GN=SLC44A3 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.43697 BP_3 15.27 1.08 974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43698 BP_3 237.47 1.79 6676 642917326 XP_008199254.1 3269 0.0e+00 PREDICTED: kazrin isoform X2 [Tribolium castaneum] 642917325 XM_008201032.1 539 0 PREDICTED: Tribolium castaneum kazrin (LOC658072), transcript variant X2, mRNA -- -- -- -- Q5FWS6 736 8.1e-76 Kazrin OS=Rattus norvegicus GN=Kazn PE=2 SV=2 PF09482//PF12285//PF14010//PF00536//PF02183//PF04923//PF07647 Bacterial type III secretion apparatus protein (OrgA_MxiK)//Protein of unknown function (DUF3621)//Phosphoenolpyruvate carboxylase//SAM domain (Sterile alpha motif)//Homeobox associated leucine zipper//Ninjurin//SAM domain (Sterile alpha motif) GO:0009405//GO:0006094//GO:0006355//GO:0006099//GO:0042246//GO:0019643//GO:0015977//GO:0007155 pathogenesis//gluconeogenesis//regulation of transcription, DNA-templated//tricarboxylic acid cycle//tissue regeneration//reductive tricarboxylic acid cycle//carbon fixation//cell adhesion GO:0008964//GO:0004252//GO:0003700//GO:0043565//GO:0005515//GO:0070008 phosphoenolpyruvate carboxylase activity//serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein binding//serine-type exopeptidase activity GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.43699 BP_3 62.23 0.34 9194 270006069 EFA02517.1 3290 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 690 0 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 Q92793 2221 7.1e-248 CREB-binding protein OS=Homo sapiens GN=CREBBP PE=1 SV=3 PF09030//PF02135//PF08214//PF16987//PF02172//PF06371//PF09468//PF07711//PF12437//PF00569//PF00439 Creb binding//TAZ zinc finger//Histone acetylation protein//KIX domain//KIX domain//Diaphanous GTPase-binding Domain//Ydr279p protein family (RNase H2 complex component)//Rab geranylgeranyl transferase alpha-subunit, insert domain//Glutamine synthetase type III N terminal//Zinc finger, ZZ type//Bromodomain GO:0009252//GO:0006807//GO:0016573//GO:0042967//GO:0006355//GO:0030036 peptidoglycan biosynthetic process//nitrogen compound metabolic process//histone acetylation//acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated//actin cytoskeleton organization GO:0004356//GO:0004402//GO:0003713//GO:0005515//GO:0017048//GO:0003779//GO:0003712//GO:0008270//GO:0004663 glutamate-ammonia ligase activity//histone acetyltransferase activity//transcription coactivator activity//protein binding//Rho GTPase binding//actin binding//transcription cofactor activity//zinc ion binding//Rab geranylgeranyltransferase activity GO:0005634//GO:0005968//GO:0005667//GO:0000123 nucleus//Rab-protein geranylgeranyltransferase complex//transcription factor complex//histone acetyltransferase complex KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.437 BP_3 23.00 0.72 1840 642937245 XP_008198754.1 241 1.4e-17 PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937247|ref|XP_008198755.1| PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937249|ref|XP_008198756.1| PREDICTED: protocadherin-15 [Tribolium castaneum] -- -- -- -- -- K16500 PCDH15 protocadherin-15 http://www.genome.jp/dbget-bin/www_bget?ko:K16500 -- -- -- -- PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.4370 BP_3 25.00 0.63 2214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43701 BP_3 104.93 0.66 8003 642935563 XP_008198060.1 3458 0.0e+00 PREDICTED: glutamate receptor-interacting protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15283 SLC35E1 solute carrier family 35, member E1 http://www.genome.jp/dbget-bin/www_bget?ko:K15283 Q9VR50 1070 1.8e-114 Solute carrier family 35 member E1 homolog OS=Drosophila melanogaster GN=CG14621 PE=2 SV=1 PF01783//PF09165//PF00892//PF08088//PF00595//PF13180 Ribosomal L32p protein family//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//EamA-like transporter family//Conotoxin I-superfamily//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006412//GO:0006119//GO:0009405//GO:0042254//GO:0015992//GO:0055114//GO:0006118 translation//oxidative phosphorylation//pathogenesis//ribosome biogenesis//proton transport//oxidation-reduction process//obsolete electron transport GO:0005515//GO:0008121//GO:0003735 protein binding//ubiquinol-cytochrome-c reductase activity//structural constituent of ribosome GO:0016021//GO:0015934//GO:0016020//GO:0005576//GO:0005840 integral component of membrane//large ribosomal subunit//membrane//extracellular region//ribosome KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.43702 BP_3 36.54 0.38 4926 91090284 XP_971237.1 1565 1.1e-170 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q92667 500 1.4e-48 A-kinase anchor protein 1, mitochondrial OS=Homo sapiens GN=AKAP1 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.43703 BP_3 2618.76 31.04 4358 91090284 XP_971237.1 1631 2.1e-178 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q92667 537 6.3e-53 A-kinase anchor protein 1, mitochondrial OS=Homo sapiens GN=AKAP1 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.43704 BP_3 19.44 0.60 1848 91090284 XP_971237.1 850 3.3e-88 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q09285 195 1.2e-13 KH domain-containing protein C56G2.1 OS=Caenorhabditis elegans GN=C56G2.1/C56G2.2 PE=3 SV=2 PF00013//PF13014//PF12409 KH domain//KH domain//P5-type ATPase cation transporter GO:0006812 cation transport GO:0003723//GO:0016887 RNA binding//ATPase activity GO:0016021 integral component of membrane KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.43705 BP_3 379.39 8.78 2375 642923613 XP_008193578.1 1719 7.2e-189 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X2 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.01356e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 1323 2.5e-144 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.43706 BP_3 5.89 1.00 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43707 BP_3 279.02 2.77 5155 2654204 AAC63079.1 1031 9.4e-109 putative juvenile hormone esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01020//PF03945 Ribosomal L40e family//delta endotoxin, N-terminal domain GO:0009405//GO:0042254//GO:0006412 pathogenesis//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.43708 BP_3 1553.05 30.69 2731 478255819 ENN76027.1 1030 6.5e-109 hypothetical protein YQE_07403, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00658//PF06305 Poly-adenylate binding protein, unique domain//Protein of unknown function (DUF1049) -- -- GO:0003723 RNA binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.43712 BP_3 677.55 15.55 2392 642923254 XP_008193679.1 749 2.2e-76 PREDICTED: DNA repair protein XRCC3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q08DH8 411 1.4e-38 DNA repair protein XRCC3 OS=Bos taurus GN=XRCC3 PE=2 SV=1 PF00154//PF03796 recA bacterial DNA recombination protein//DnaB-like helicase C terminal domain GO:0006260//GO:0009432//GO:0006281 DNA replication//SOS response//DNA repair GO:0005524//GO:0003678//GO:0003697 ATP binding//DNA helicase activity//single-stranded DNA binding GO:0005657 replication fork KOG1564 DNA repair protein RHP57 Cluster-8309.43713 BP_3 26.34 0.54 2636 167234455 NP_001107843.1 1160 5.3e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.4e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43714 BP_3 335.49 2.05 8193 642918562 XP_008199292.1 1023 1.3e-107 PREDICTED: large proline-rich protein BAG6 isoform X1 [Tribolium castaneum] 242016373 XM_002428751.1 60 1.65424e-19 Pediculus humanus corporis RWD domain-containing protein, putative, mRNA -- -- -- -- A4IH17 240 3.2e-18 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF07469//PF14560//PF00240//PF05773 Domain of unknown function (DUF1518)//Ubiquitin-like domain//Ubiquitin family//RWD domain -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4018 Uncharacterized conserved protein, contains RWD domain Cluster-8309.43716 BP_3 436.23 2.71 8059 642928738 XP_008199761.1 3549 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|642928740|ref|XP_008199762.1| PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|270009769|gb|EFA06217.1| hypothetical protein TcasGA2_TC009066 [Tribolium castaneum] 642928739 XM_008201540.1 59 5.85196e-19 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 4 regulatory subunit 3 (LOC663105), transcript variant X2, mRNA K17491 SMEK, PPP4R3 protein phosphatase 4 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17491 Q9VFS5 2688 4.4e-302 Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Drosophila melanogaster GN=flfl PE=1 SV=4 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG2175 Protein predicted to be involved in carbohydrate metabolism Cluster-8309.43717 BP_3 83.66 0.52 8097 642928738 XP_008199761.1 3549 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|642928740|ref|XP_008199762.1| PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|270009769|gb|EFA06217.1| hypothetical protein TcasGA2_TC009066 [Tribolium castaneum] 642928739 XM_008201540.1 59 5.87968e-19 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 4 regulatory subunit 3 (LOC663105), transcript variant X2, mRNA K17491 SMEK, PPP4R3 protein phosphatase 4 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17491 Q9VFS5 2688 4.4e-302 Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Drosophila melanogaster GN=flfl PE=1 SV=4 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG2175 Protein predicted to be involved in carbohydrate metabolism Cluster-8309.43719 BP_3 211.97 7.04 1744 546673729 ERL85285.1 1122 8.9e-120 hypothetical protein D910_02706 [Dendroctonus ponderosae] -- -- -- -- -- K10812 GlcAT-SP beta-1,3-glucuronyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10812 Q9VTG7 854 4.4e-90 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P OS=Drosophila melanogaster GN=GlcAT-P PE=2 SV=1 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.43722 BP_3 62.48 0.75 4303 270008659 EFA05107.1 3005 0.0e+00 hypothetical protein TcasGA2_TC015207 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 P42893 1657 8.3e-183 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF01431//PF01447//PF05649 Peptidase family M13//Thermolysin metallopeptidase, catalytic domain//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.43723 BP_3 586.00 343.52 371 478255731 ENN75940.1 220 7.4e-16 hypothetical protein YQE_07475, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43726 BP_3 703.32 24.87 1655 91082187 XP_971460.1 565 3.3e-55 PREDICTED: prostaglandin E synthase 3 [Tribolium castaneum]>gi|270007441|gb|EFA03889.1| hypothetical protein TcasGA2_TC014013 [Tribolium castaneum] -- -- -- -- -- K15730 PTGES3 cytosolic prostaglandin-E synthase http://www.genome.jp/dbget-bin/www_bget?ko:K15730 Q9VH95 227 2.1e-17 Uncharacterized protein CG16817 OS=Drosophila melanogaster GN=CG16817 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3158 HSP90 co-chaperone p23 Cluster-8309.43727 BP_3 103.15 2.70 2132 642931467 XP_966826.3 1593 2.6e-174 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q05B81 249 7.6e-20 Proton-coupled folate transporter OS=Bos taurus GN=SLC46A1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.43728 BP_3 21.32 0.85 1496 91081359 XP_971395.1 1180 1.4e-126 PREDICTED: tumor suppressor candidate 3 [Tribolium castaneum]>gi|270005188|gb|EFA01636.1| hypothetical protein TcasGA2_TC007206 [Tribolium castaneum] 571501133 XM_395605.5 170 2.10563e-81 PREDICTED: Apis mellifera magnesium transporter protein 1-like (LOC412141), mRNA K12669 OST3, OST6 oligosaccharyltransferase complex subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K12669 Q13454 906 3.5e-96 Tumor suppressor candidate 3 OS=Homo sapiens GN=TUSC3 PE=1 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2603 Oligosaccharyltransferase, gamma subunit Cluster-8309.43731 BP_3 208.23 2.12 5024 847140834 XP_012821161.1 437 6.9e-40 PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis]>gi|847140836|ref|XP_012821162.1| PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- E9QAG8 409 5.0e-38 Zinc finger protein 431 OS=Mus musculus GN=Znf431 PE=1 SV=1 PF17123//PF07776//PF00096//PF02892//PF13912//PF05485//PF16622//PF13465 RING-like zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//BED zinc finger//C2H2-type zinc finger//THAP domain//zinc-finger C2H2-type//Zinc-finger double domain -- -- GO:0046872//GO:0005515//GO:0008270//GO:0003677//GO:0003676 metal ion binding//protein binding//zinc ion binding//DNA binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.43732 BP_3 1651.32 6.91 11810 478258209 ENN78338.1 4936 0.0e+00 hypothetical protein YQE_05141, partial [Dendroctonus ponderosae] 642917861 XM_008193096.1 510 0 PREDICTED: Tribolium castaneum protein dopey-1 homolog (LOC656419), mRNA -- -- -- -- A1ZBE8 1965 4.4e-218 Protein dopey-1 homolog OS=Drosophila melanogaster GN=CG15099 PE=1 SV=1 PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0000775//GO:0005634 chromosome, centromeric region//nucleus KOG2957 Vacuolar H+-ATPase V0 sector, subunit d Cluster-8309.43733 BP_3 111.57 0.62 9009 270005301 EFA01749.1 185 2.1e-10 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 159 8.8e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01533//PF04608//PF00096//PF09728//PF05485//PF02892//PF01708 Tospovirus nucleocapsid protein//Phosphatidylglycerophosphatase A//Zinc finger, C2H2 type//Myosin-like coiled-coil protein//THAP domain//BED zinc finger//Geminivirus putative movement protein GO:0046486//GO:0046740//GO:0006629 glycerolipid metabolic process//transport of virus in host, cell to cell//lipid metabolic process GO:0003676//GO:0008962//GO:0046872//GO:0003677//GO:0019905 nucleic acid binding//phosphatidylglycerophosphatase activity//metal ion binding//DNA binding//syntaxin binding GO:0019013//GO:0016021 viral nucleocapsid//integral component of membrane -- -- Cluster-8309.43734 BP_3 35.14 4.46 671 91090364 XP_968231.1 370 5.4e-33 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5U6 228 6.5e-18 RING finger protein 10 OS=Homo sapiens GN=RNF10 PE=1 SV=2 -- -- -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG2164 Predicted E3 ubiquitin ligase Cluster-8309.43737 BP_3 188.68 1.79 5360 642934874 XP_008197845.1 2625 1.4e-293 PREDICTED: ecdysone-induced protein 75B, isoforms C/D isoform X4 [Tribolium castaneum] 443682249 KC020244.1 254 1.547e-127 Monochamus alternatus ecdysone-induced protein 75-like protein (E75) mRNA, partial cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1308 3.1e-142 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00105//PF01213//PF00104//PF05805 Zinc finger, C4 type (two domains)//Adenylate cyclase associated (CAP) N terminal//Ligand-binding domain of nuclear hormone receptor//L6 membrane protein GO:0006355//GO:0043401//GO:0007010 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//cytoskeleton organization GO:0003700//GO:0008270//GO:0043565//GO:0003779 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding//actin binding GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus KOG4846 Nuclear receptor Cluster-8309.43738 BP_3 141.51 1.58 4605 642915162 XP_008190500.1 1424 2.3e-154 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02562 149 6.5e-08 Myosin heavy chain, skeletal muscle (Fragments) OS=Oryctolagus cuniculus PE=1 SV=2 PF02135 TAZ zinc finger GO:0042967//GO:0006355 acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0004402//GO:0008270//GO:0003712 histone acetyltransferase activity//zinc ion binding//transcription cofactor activity GO:0005634//GO:0005667//GO:0000123 nucleus//transcription factor complex//histone acetyltransferase complex -- -- Cluster-8309.43739 BP_3 10.00 0.91 820 642937603 XP_008199117.1 184 2.5e-11 PREDICTED: uncharacterized protein LOC103314536 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43744 BP_3 27.00 1.62 1095 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43746 BP_3 41.00 0.90 2490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43752 BP_3 254.95 0.79 15750 546679672 ERL90099.1 6770 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 3978 0.0e+00 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF00515//PF13374//PF14604//PF00018//PF08141//PF00462//PF13176//PF13414//PF13181//PF00389//PF03493//PF02826//PF03446 Tetratricopeptide repeat//Tetratricopeptide repeat//Variant SH3 domain//SH3 domain//Small acid-soluble spore protein H family//Glutaredoxin//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006813//GO:0008152//GO:0006098//GO:0045454//GO:0055114//GO:0006118//GO:0030436//GO:0019521 potassium ion transport//metabolic process//pentose-phosphate shunt//cell redox homeostasis//oxidation-reduction process//obsolete electron transport//asexual sporulation//D-gluconate metabolic process GO:0051287//GO:0005515//GO:0009055//GO:0015035//GO:0016616//GO:0015269//GO:0004616 NAD binding//protein binding//electron carrier activity//protein disulfide oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//calcium-activated potassium channel activity//phosphogluconate dehydrogenase (decarboxylating) activity GO:0016020//GO:0042601 membrane//endospore-forming forespore KOG1998 Signaling protein DOCK180 Cluster-8309.43753 BP_3 1201.44 4.07 14507 546679672 ERL90099.1 6770 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 3978 0.0e+00 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF00515//PF13374//PF08141//PF00018//PF14604//PF13176//PF00462//PF13414//PF13181//PF00389//PF03493//PF02826//PF03446 Tetratricopeptide repeat//Tetratricopeptide repeat//Small acid-soluble spore protein H family//SH3 domain//Variant SH3 domain//Tetratricopeptide repeat//Glutaredoxin//TPR repeat//Tetratricopeptide repeat//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0019521//GO:0030436//GO:0006118//GO:0045454//GO:0006813//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//asexual sporulation//obsolete electron transport//cell redox homeostasis//potassium ion transport//metabolic process//pentose-phosphate shunt GO:0004616//GO:0015269//GO:0016616//GO:0015035//GO:0009055//GO:0005515//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//calcium-activated potassium channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//protein disulfide oxidoreductase activity//electron carrier activity//protein binding//NAD binding GO:0042601//GO:0016020 endospore-forming forespore//membrane KOG1998 Signaling protein DOCK180 Cluster-8309.43755 BP_3 383.00 5.99 3372 546678030 ERL88754.1 994 1.2e-104 hypothetical protein D910_06136 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5NVC7 440 8.6e-42 E3 ubiquitin-protein ligase RNF34 OS=Pongo abelii GN=RNF34 PE=2 SV=2 PF15323//PF14634//PF12906//PF13639 Developmental protein//zinc-RING finger domain//RING-variant domain//Ring finger domain GO:0048598 embryonic morphogenesis GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0072669 tRNA-splicing ligase complex -- -- Cluster-8309.43758 BP_3 340.65 6.58 2788 642933410 XP_008197405.1 2321 1.3e-258 PREDICTED: sodium-independent sulfate anion transporter isoform X2 [Tribolium castaneum] 644991717 XM_001603675.3 264 2.20766e-133 PREDICTED: Nasonia vitripennis sodium-independent sulfate anion transporter (LOC100120043), mRNA K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 959 4.7e-102 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.43759 BP_3 211.90 6.63 1832 91089905 XP_972496.1 1215 1.5e-130 PREDICTED: UDP-glucuronosyltransferase [Tribolium castaneum]>gi|270013659|gb|EFA10107.1| hypothetical protein TcasGA2_TC012286 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 577 6.1e-58 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758//GO:0016740 transferase activity, transferring hexosyl groups//transferase activity -- -- -- -- Cluster-8309.43762 BP_3 417.24 4.26 5017 546684675 ERL94292.1 1147 3.2e-122 hypothetical protein D910_11573 [Dendroctonus ponderosae] -- -- -- -- -- K13219 SFPQ, PSF splicing factor, proline- and glutamine-rich http://www.genome.jp/dbget-bin/www_bget?ko:K13219 Q9U1N0 962 3.8e-102 Hrp65 protein OS=Chironomus tentans GN=HRP65 PE=1 SV=1 PF02601//PF00076 Exonuclease VII, large subunit//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006308 DNA catabolic process GO:0003676//GO:0008855 nucleic acid binding//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG0115 RNA-binding protein p54nrb (RRM superfamily) Cluster-8309.43765 BP_3 91.77 1.19 4021 642926686 XP_008194968.1 2027 2.4e-224 PREDICTED: optomotor-blind protein [Tribolium castaneum] 815905935 XM_012383383.1 239 2.52427e-119 PREDICTED: Bombus impatiens optomotor-blind protein (LOC100740497), partial mRNA K10177 TBX3 T-box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10177 Q24432 1212 3.1e-131 Optomotor-blind protein OS=Drosophila melanogaster GN=bi PE=1 SV=3 PF06624//PF00907 Ribosome associated membrane protein RAMP4//T-box GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005783 nucleus//transcription factor complex//endoplasmic reticulum KOG3585 TBX2 and related T-box transcription factors Cluster-8309.43766 BP_3 56.12 1.13 2679 189240077 XP_971167.2 1503 9.1e-164 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 190 6.7e-13 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.43768 BP_3 69.06 0.35 9701 642918656 XP_008191524.1 2229 2.2e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.4e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF01799//PF07714//PF00069//PF13520//PF00463//PF00433//PF07535//PF06220 [2Fe-2S] binding domain//Protein tyrosine kinase//Protein kinase domain//Amino acid permease//Isocitrate lyase family//Protein kinase C terminal domain//DBF zinc finger//U1 zinc finger GO:0055114//GO:0006097//GO:0009069//GO:0006468//GO:0003333//GO:0019752//GO:0016310//GO:0006865 oxidation-reduction process//glyoxylate cycle//serine family amino acid metabolic process//protein phosphorylation//amino acid transmembrane transport//carboxylic acid metabolic process//phosphorylation//amino acid transport GO:0004674//GO:0008270//GO:0015171//GO:0005524//GO:0004672//GO:0046872//GO:0003676//GO:0016491//GO:0004451//GO:0005543 protein serine/threonine kinase activity//zinc ion binding//amino acid transmembrane transporter activity//ATP binding//protein kinase activity//metal ion binding//nucleic acid binding//oxidoreductase activity//isocitrate lyase activity//phospholipid binding GO:0016020 membrane KOG0690 Serine/threonine protein kinase Cluster-8309.43770 BP_3 2032.50 10.62 9519 642911194 XP_008199555.1 11434 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X2 [Tribolium castaneum] 805816093 XM_012293284.1 544 0 PREDICTED: Megachile rotundata inositol 1,4,5-trisphosphate receptor (LOC100879087), transcript variant X3, mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 8769 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF00520//PF01365//PF02815 Ion transport protein//RIH domain//MIR domain GO:0006816//GO:0055085//GO:0006811//GO:0070588 calcium ion transport//transmembrane transport//ion transport//calcium ion transmembrane transport GO:0005216//GO:0005262 ion channel activity//calcium channel activity GO:0016020 membrane KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.43773 BP_3 145.19 1.79 4208 190702371 ACE75264.1 1541 5.6e-168 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00751//PF03175 DM DNA binding domain//DNA polymerase type B, organellar and viral GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008408//GO:0043565//GO:0000166//GO:0003677//GO:0003887 3'-5' exonuclease activity//sequence-specific DNA binding//nucleotide binding//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.43777 BP_3 40.92 0.49 4302 546684921 ERL94503.1 2312 2.3e-257 hypothetical protein D910_11780 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96MT7 747 2.8e-77 Cilia- and flagella-associated protein 44 OS=Homo sapiens GN=CFAP44 PE=1 SV=1 PF05104//PF00591//PF00400 Ribosome receptor lysine/proline rich region//Glycosyl transferase family, a/b domain//WD domain, G-beta repeat GO:0008152//GO:0015031 metabolic process//protein transport GO:0016757//GO:0005515 transferase activity, transferring glycosyl groups//protein binding GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.43778 BP_3 1971.74 12.39 7960 189238786 XP_974651.2 2965 0.0e+00 PREDICTED: putative RNA-binding protein 15B [Tribolium castaneum] 662187094 XM_008487201.1 150 1.49723e-69 PREDICTED: Diaphorina citri putative RNA-binding protein 15 (LOC103522090), mRNA K13190 RBM15 RNA-binding protein 15 http://www.genome.jp/dbget-bin/www_bget?ko:K13190 Q96T37 714 3.4e-73 Putative RNA-binding protein 15 OS=Homo sapiens GN=RBM15 PE=1 SV=2 PF00558//PF00076//PF16367//PF00789//PF02313//PF08777//PF15281 Vpu protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//UBX domain//Fumarate reductase subunit D//RNA binding motif//Consortin C-terminus GO:0006812//GO:0032801//GO:0006106//GO:0042998//GO:0019076 cation transport//receptor catabolic process//fumarate metabolic process//positive regulation of Golgi to plasma membrane protein transport//viral release from host cell GO:0003676//GO:0003723//GO:0005261//GO:0005515//GO:0071253 nucleic acid binding//RNA binding//cation channel activity//protein binding//connexin binding GO:0016020//GO:0033644//GO:0005802 membrane//host cell membrane//trans-Golgi network KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.43779 BP_3 2106.02 13.10 8039 189238786 XP_974651.2 2965 0.0e+00 PREDICTED: putative RNA-binding protein 15B [Tribolium castaneum] 662187094 XM_008487201.1 150 1.51215e-69 PREDICTED: Diaphorina citri putative RNA-binding protein 15 (LOC103522090), mRNA K13190 RBM15 RNA-binding protein 15 http://www.genome.jp/dbget-bin/www_bget?ko:K13190 Q96T37 714 3.5e-73 Putative RNA-binding protein 15 OS=Homo sapiens GN=RBM15 PE=1 SV=2 PF15281//PF00789//PF08777//PF02313//PF00076//PF00558//PF16367 Consortin C-terminus//UBX domain//RNA binding motif//Fumarate reductase subunit D//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Vpu protein//RNA recognition motif GO:0019076//GO:0042998//GO:0006812//GO:0032801//GO:0006106 viral release from host cell//positive regulation of Golgi to plasma membrane protein transport//cation transport//receptor catabolic process//fumarate metabolic process GO:0003723//GO:0005515//GO:0071253//GO:0005261//GO:0003676 RNA binding//protein binding//connexin binding//cation channel activity//nucleic acid binding GO:0005802//GO:0016020//GO:0033644 trans-Golgi network//membrane//host cell membrane KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.43785 BP_3 39.61 0.91 2385 642927926 XP_001814448.2 1898 1.3e-209 PREDICTED: LOW QUALITY PROTEIN: membralin [Tribolium castaneum] 642927925 XM_001814396.2 309 1.82023e-158 PREDICTED: Tribolium castaneum membralin (LOC663408), mRNA -- -- -- -- Q4ZIN3 1161 1.5e-125 Membralin OS=Homo sapiens GN=TMEM259 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2092 Uncharacterized conserved protein Cluster-8309.43788 BP_3 752.30 9.70 4030 478260571 ENN80274.1 706 3.6e-71 hypothetical protein YQE_03268, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF15220//PF03323 MAP7 (E-MAP-115) family//Hypoxia-inducible lipid droplet-associated//Bacillus/Clostridium GerA spore germination protein GO:0009847//GO:0008284//GO:0010884//GO:0000226//GO:0001819 spore germination//positive regulation of cell proliferation//positive regulation of lipid storage//microtubule cytoskeleton organization//positive regulation of cytokine production -- -- GO:0016021//GO:0015630 integral component of membrane//microtubule cytoskeleton -- -- Cluster-8309.43789 BP_3 619.36 74.95 690 322793851 EFZ17191.1 257 7.1e-20 hypothetical protein SINV_15085, partial [Solenopsis invicta] 808119683 XM_012307943.1 60 1.33179e-20 PREDICTED: Bombus terrestris 40S ribosomal protein S28 (LOC105665663), mRNA K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 Q9W334 233 1.8e-18 40S ribosomal protein S28 OS=Drosophila melanogaster GN=RpS28b PE=1 SV=2 PF01176//PF01200//PF03367 Translation initiation factor 1A / IF-1//Ribosomal protein S28e//ZPR1 zinc-finger domain GO:0042254//GO:0006413//GO:0006446//GO:0006412 ribosome biogenesis//translational initiation//regulation of translational initiation//translation GO:0008270//GO:0003735//GO:0003723//GO:0003743 zinc ion binding//structural constituent of ribosome//RNA binding//translation initiation factor activity GO:0005840//GO:0005622 ribosome//intracellular KOG3502 40S ribosomal protein S28 Cluster-8309.43790 BP_3 816.60 12.65 3404 91084021 XP_975350.1 2531 7.2e-283 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 571571862 XM_006564848.1 565 0 PREDICTED: Apis mellifera uncharacterized LOC551823 (LOC551823), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q9BUQ8 2115 5.1e-236 Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens GN=DDX23 PE=1 SV=3 PF00270//PF06862//PF00176//PF04851 DEAD/DEAH box helicase//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0016787//GO:0003677//GO:0003676//GO:0008026 ATP binding//hydrolase activity//DNA binding//nucleic acid binding//ATP-dependent helicase activity GO:0005634 nucleus KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.43791 BP_3 813.21 6.11 6707 642920095 XP_008192202.1 1742 4.4e-191 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 7.42662e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.0e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43794 BP_3 135.17 0.94 7237 332372760 AEE61522.1 509 4.5e-48 unknown [Dendroctonus ponderosae]>gi|478251664|gb|ENN72118.1| hypothetical protein YQE_11177, partial [Dendroctonus ponderosae]>gi|478262743|gb|ENN81274.1| hypothetical protein YQE_02310, partial [Dendroctonus ponderosae]>gi|546680918|gb|ERL91092.1| hypothetical protein D910_08434 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38718 366 7.0e-33 Mitochondrial pyruvate carrier 2 OS=Rattus norvegicus GN=Mpc2 PE=2 SV=1 PF03650//PF02790 Uncharacterised protein family (UPF0041)//Cytochrome C oxidase subunit II, transmembrane domain GO:0022900//GO:0006850 electron transport chain//mitochondrial pyruvate transport -- -- GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG1589 Uncharacterized conserved protein Cluster-8309.43796 BP_3 1284.79 8.94 7216 642912703 XP_008200968.1 4488 0.0e+00 PREDICTED: cytoskeleton-associated protein 5 [Tribolium castaneum]>gi|270002915|gb|EEZ99362.1| mini spindles [Tribolium castaneum] 642912702 XM_008202746.1 130 1.77992e-58 PREDICTED: Tribolium castaneum cytoskeleton-associated protein 5 (LOC659068), mRNA K16803 CKAP5, XMAP215 cytoskeleton-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16803 Q14008 1971 5.4e-219 Cytoskeleton-associated protein 5 OS=Homo sapiens GN=CKAP5 PE=1 SV=3 PF02985//PF11640//PF12422//PF08465 HEAT repeat//Telomere-length maintenance and DNA damage repair//Condensin II non structural maintenance of chromosomes subunit//Thymidine kinase from Herpesvirus C-terminal GO:0006206//GO:0016310//GO:0009069//GO:0006230 pyrimidine nucleobase metabolic process//phosphorylation//serine family amino acid metabolic process//TMP biosynthetic process GO:0004674//GO:0005515//GO:0004797//GO:0005524 protein serine/threonine kinase activity//protein binding//thymidine kinase activity//ATP binding GO:0005634 nucleus KOG1820 Microtubule-associated protein Cluster-8309.43797 BP_3 108.00 1.04 5298 642934118 XP_008199283.1 1895 6.3e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1299 3.3e-141 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0006865//GO:0055085//GO:0003333//GO:0006810 amino acid transport//transmembrane transport//amino acid transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.43799 BP_3 78.05 0.47 8225 91091444 XP_972566.1 1855 4.3e-204 PREDICTED: succinate-semialdehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270000977|gb|EEZ97424.1| hypothetical protein TcasGA2_TC011254 [Tribolium castaneum] -- -- -- -- -- K00139 ALDH5A1 succinate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00139 Q3MSM3 1320 1.9e-143 Succinate-semialdehyde dehydrogenase, mitochondrial OS=Hylobates lar GN=ALDH5A1 PE=2 SV=1 PF00013//PF00171 KH domain//Aldehyde dehydrogenase family GO:0009450//GO:0008152//GO:0006570//GO:0055114 gamma-aminobutyric acid catabolic process//metabolic process//tyrosine metabolic process//oxidation-reduction process GO:0009013//GO:0003723//GO:0016491 succinate-semialdehyde dehydrogenase [NAD(P)+] activity//RNA binding//oxidoreductase activity -- -- KOG2451 Aldehyde dehydrogenase Cluster-8309.43800 BP_3 1448.64 7.68 9387 546684330 ERL94035.1 3979 0.0e+00 hypothetical protein D910_11318 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O94812 756 5.5e-78 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF02947//PF00168//PF08392//PF01688 flt3 ligand//C2 domain//FAE1/Type III polyketide synthase-like protein//Alphaherpesvirus glycoprotein I GO:0007165//GO:0006633 signal transduction//fatty acid biosynthetic process GO:0016747//GO:0005515//GO:0005125 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//cytokine activity GO:0043657//GO:0016020 host cell//membrane KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.43803 BP_3 235.93 2.85 4281 642932431 XP_008197110.1 2076 5.2e-230 PREDICTED: uncharacterized protein LOC100141760 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43804 BP_3 185.00 1.71 5511 642915654 XP_008190698.1 870 4.7e-90 PREDICTED: uncharacterized protein LOC103312268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05745//PF03153//PF04103 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)//Transcription factor IIA, alpha/beta subunit//CD20-like family GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0019867//GO:0005672//GO:0016021 outer membrane//transcription factor TFIIA complex//integral component of membrane -- -- Cluster-8309.43806 BP_3 688.56 15.87 2383 91092788 XP_974007.1 919 4.2e-96 PREDICTED: dual specificity protein phosphatase 10 [Tribolium castaneum]>gi|270014786|gb|EFA11234.1| hypothetical protein TcasGA2_TC010766 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q0IID7 428 1.5e-40 Dual specificity protein phosphatase 10 OS=Bos taurus GN=DUSP10 PE=2 SV=1 PF05706//PF00102//PF04179//PF00782 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470//GO:0019988//GO:0035335 tyrosine metabolic process//protein dephosphorylation//charged-tRNA amino acid modification//peptidyl-tyrosine dephosphorylation GO:0043399//GO:0017017//GO:0004725//GO:0008138//GO:0004721 tRNA A64-2'-O-ribosylphosphate transferase activity//MAP kinase tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity -- -- KOG1716 Dual specificity phosphatase Cluster-8309.43808 BP_3 318.81 3.69 4453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43816 BP_3 65.42 2.17 1745 642939092 XP_008200218.1 530 4.0e-51 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06209 Cofactor of BRCA1 (COBRA1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.43817 BP_3 20.77 0.60 1970 642939092 XP_008200218.1 686 3.6e-69 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606//PF06209 Ankyrin repeat//Ankyrin repeat//Cofactor of BRCA1 (COBRA1) GO:0045892 negative regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.43818 BP_3 66.75 1.81 2074 642939092 XP_008200218.1 955 2.5e-100 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFX9 186 1.5e-12 Tankyrase-1 OS=Mus musculus GN=Tnks PE=1 SV=1 PF06209//PF13606//PF00023 Cofactor of BRCA1 (COBRA1)//Ankyrin repeat//Ankyrin repeat GO:0045892 negative regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.43820 BP_3 653.12 16.49 2201 189242426 XP_969950.2 1190 1.5e-127 PREDICTED: ankyrin repeat domain-containing protein 12 isoform X3 [Tribolium castaneum] 642939093 XM_964857.3 235 2.29662e-117 PREDICTED: Tribolium castaneum ankyrin repeat domain-containing protein 11 (LOC658469), transcript variant X3, mRNA -- -- -- -- Q6UB98 509 5.6e-50 Ankyrin repeat domain-containing protein 12 OS=Homo sapiens GN=ANKRD12 PE=1 SV=3 PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.43821 BP_3 72.71 1.68 2373 189242426 XP_969950.2 1190 1.6e-127 PREDICTED: ankyrin repeat domain-containing protein 12 isoform X3 [Tribolium castaneum] 642939093 XM_964857.3 235 2.47899e-117 PREDICTED: Tribolium castaneum ankyrin repeat domain-containing protein 11 (LOC658469), transcript variant X3, mRNA -- -- -- -- Q6UB98 509 6.0e-50 Ankyrin repeat domain-containing protein 12 OS=Homo sapiens GN=ANKRD12 PE=1 SV=3 PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.43823 BP_3 15.00 0.62 1463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43824 BP_3 124.62 4.71 1568 668451731 KFB40787.1 242 8.8e-18 hypothetical protein ZHAS_00008218 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- O95271 233 4.0e-18 Tankyrase-1 OS=Homo sapiens GN=TNKS PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43826 BP_3 1130.67 41.75 1597 642939092 XP_008200218.1 530 3.6e-51 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06209 Cofactor of BRCA1 (COBRA1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.43827 BP_3 21.41 0.36 3187 189242426 XP_969950.2 1190 2.1e-127 PREDICTED: ankyrin repeat domain-containing protein 12 isoform X3 [Tribolium castaneum] 642939093 XM_964857.3 235 3.33997e-117 PREDICTED: Tribolium castaneum ankyrin repeat domain-containing protein 11 (LOC658469), transcript variant X3, mRNA -- -- -- -- Q6UB98 509 8.1e-50 Ankyrin repeat domain-containing protein 12 OS=Homo sapiens GN=ANKRD12 PE=1 SV=3 PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.43828 BP_3 34.76 0.56 3300 642939090 XP_008200217.1 1190 2.2e-127 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X1 [Tribolium castaneum] 642939093 XM_964857.3 235 3.45975e-117 PREDICTED: Tribolium castaneum ankyrin repeat domain-containing protein 11 (LOC658469), transcript variant X3, mRNA -- -- -- -- Q6UB98 509 8.4e-50 Ankyrin repeat domain-containing protein 12 OS=Homo sapiens GN=ANKRD12 PE=1 SV=3 PF01818//PF01405 Bacteriophage translational regulator//Photosystem II reaction centre T protein GO:0015979 photosynthesis GO:0003723 RNA binding GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.43829 BP_3 1814.09 25.48 3723 546676181 ERL87248.1 2487 1.0e-277 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9I9 673 9.1e-69 Mycosubtilin synthase subunit C OS=Bacillus subtilis GN=mycC PE=3 SV=1 PF02733//PF00501 Dak1 domain//AMP-binding enzyme GO:0046486//GO:0006071//GO:0008152 glycerolipid metabolic process//glycerol metabolic process//metabolic process GO:0004371//GO:0003824 glycerone kinase activity//catalytic activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.43831 BP_3 775.93 11.06 3672 270014366 EFA10814.1 2201 1.4e-244 hypothetical protein TcasGA2_TC030632 [Tribolium castaneum] -- -- -- -- -- K09189 MLL5 histone-lysine N-methyltransferase MLL5 http://www.genome.jp/dbget-bin/www_bget?ko:K09189 Q3UG20 509 9.3e-50 Histone-lysine N-methyltransferase 2E OS=Mus musculus GN=Kmt2e PE=1 SV=2 PF00856//PF00569//PF00628//PF01033//PF07496 SET domain//Zinc finger, ZZ type//PHD-finger//Somatomedin B domain//CW-type Zinc Finger GO:0007165//GO:0006955 signal transduction//immune response GO:0005515//GO:0008270//GO:0005044//GO:0030247 protein binding//zinc ion binding//scavenger receptor activity//polysaccharide binding -- -- KOG1844 PHD Zn-finger proteins Cluster-8309.43832 BP_3 373.22 22.04 1108 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43833 BP_3 786.69 8.53 4737 189235385 XP_969534.2 4402 0.0e+00 PREDICTED: regulator of nonsense transcripts 2 [Tribolium castaneum] -- -- -- -- -- K14327 UPF2, RENT2 regulator of nonsense transcripts 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14327 Q9HAU5 2203 4.5e-246 Regulator of nonsense transcripts 2 OS=Homo sapiens GN=UPF2 PE=1 SV=1 PF02854 MIF4G domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2051 Nonsense-mediated mRNA decay 2 protein Cluster-8309.43834 BP_3 55.37 0.76 3781 91094585 XP_969953.1 1122 1.9e-119 PREDICTED: parathyroid hormone/parathyroid hormone-related peptide receptor [Tribolium castaneum]>gi|270016404|gb|EFA12850.1| hypothetical protein TcasGA2_TC010267 [Tribolium castaneum]>gi|570932721|gb|AHF20217.1| parathyroid hormone receptor like 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25107 511 5.6e-50 Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Didelphis virginiana GN=PTH1R PE=2 SV=2 PF00800//PF00002//PF02793//PF00466 Prephenate dehydratase//7 transmembrane receptor (Secretin family)//Hormone receptor domain//Ribosomal protein L10 GO:0007165//GO:0006571//GO:0042254//GO:0000162//GO:0009094//GO:0007186 signal transduction//tyrosine biosynthetic process//ribosome biogenesis//tryptophan biosynthetic process//L-phenylalanine biosynthetic process//G-protein coupled receptor signaling pathway GO:0004664//GO:0004930//GO:0004871 prephenate dehydratase activity//G-protein coupled receptor activity//signal transducer activity GO:0016021//GO:0005622//GO:0016020 integral component of membrane//intracellular//membrane -- -- Cluster-8309.43835 BP_3 549.00 9.01 3227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43836 BP_3 6.00 0.64 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43837 BP_3 288.05 5.83 2673 531445261 AGT57839.1 756 3.8e-77 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 547 2.7e-54 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.43839 BP_3 1978.32 16.07 6226 270003174 EEZ99621.1 1609 1.1e-175 hypothetical protein TcasGA2_TC002139 [Tribolium castaneum] 817079739 XM_012406879.1 41 4.58132e-09 PREDICTED: Athalia rosae thioredoxin-related transmembrane protein 1-like (LOC105689684), mRNA K14832 MAK21, NOC1, CEBPZ ribosome biogenesis protein MAK21 http://www.genome.jp/dbget-bin/www_bget?ko:K14832 Q03701 977 8.5e-104 CCAAT/enhancer-binding protein zeta OS=Homo sapiens GN=CEBPZ PE=1 SV=3 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein Cluster-8309.43840 BP_3 27.37 0.47 3114 189235122 XP_001811652.1 3202 0.0e+00 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 317 8.51166e-163 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1895 1.5e-210 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF01496//PF00856 V-type ATPase 116kDa subunit family//SET domain GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078//GO:0003682//GO:0005515 hydrogen ion transmembrane transporter activity//chromatin binding//protein binding GO:0000785//GO:0033179 chromatin//proton-transporting V-type ATPase, V0 domain KOG1079 Transcriptional repressor EZH1 Cluster-8309.43841 BP_3 26.26 0.41 3357 546676387 ERL87409.1 794 1.9e-81 hypothetical protein D910_04804 [Dendroctonus ponderosae] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 578 8.5e-58 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF01370//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.43842 BP_3 729.21 5.57 6605 270014159 EFA10607.1 893 1.2e-92 hypothetical protein TcasGA2_TC012868 [Tribolium castaneum] 642936629 XM_008200293.1 231 1.16461e-114 PREDICTED: Tribolium castaneum serine-arginine protein 55-like (LOC660636), mRNA K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 732 2.3e-75 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF04179//PF08777//PF00102//PF00782//PF01529//PF02868//PF01416//PF16367//PF00076 Initiator tRNA phosphoribosyl transferase//RNA binding motif//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//DHHC palmitoyltransferase//Thermolysin metallopeptidase, alpha-helical domain//tRNA pseudouridine synthase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0001522//GO:0009451//GO:0019988//GO:0006570//GO:0006470 pseudouridine synthesis//RNA modification//charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation GO:0008270//GO:0009982//GO:0003676//GO:0004725//GO:0008138//GO:0004222//GO:0003723//GO:0043399 zinc ion binding//pseudouridine synthase activity//nucleic acid binding//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//metalloendopeptidase activity//RNA binding//tRNA A64-2'-O-ribosylphosphate transferase activity -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.43844 BP_3 479.95 3.76 6446 91076790 XP_974060.1 1407 3.0e-152 PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|642913035|ref|XP_008201360.1| PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|270001925|gb|EEZ98372.1| hypothetical protein TcasGA2_TC000831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88879 532 3.5e-52 Apoptotic protease-activating factor 1 OS=Mus musculus GN=Apaf1 PE=1 SV=3 PF00931//PF00619//PF07569//PF00400 NB-ARC domain//Caspase recruitment domain//TUP1-like enhancer of split//WD domain, G-beta repeat GO:0042981//GO:0006355 regulation of apoptotic process//regulation of transcription, DNA-templated GO:0005515//GO:0043531 protein binding//ADP binding GO:0005634 nucleus -- -- Cluster-8309.43848 BP_3 2036.70 47.58 2355 189238127 XP_001814833.1 1517 1.9e-165 PREDICTED: lachesin [Tribolium castaneum]>gi|270008732|gb|EFA05180.1| hypothetical protein TcasGA2_TC015310 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 1312 4.6e-143 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43849 BP_3 26.01 0.55 2562 189238127 XP_001814833.1 1411 4.0e-153 PREDICTED: lachesin [Tribolium castaneum]>gi|270008732|gb|EFA05180.1| hypothetical protein TcasGA2_TC015310 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 1248 1.3e-135 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43850 BP_3 1852.28 40.43 2500 189238127 XP_001814833.1 933 1.1e-97 PREDICTED: lachesin [Tribolium castaneum]>gi|270008732|gb|EFA05180.1| hypothetical protein TcasGA2_TC015310 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 809 1.0e-84 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895//PF04369 Immunoglobulin domain//Lactococcin-like family GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0005576 extracellular region -- -- Cluster-8309.43852 BP_3 1900.72 31.19 3229 157125048 XP_001660595.1 2233 2.5e-248 AAEL010063-PA [Aedes aegypti]>gi|108873778|gb|EAT38003.1| AAEL010063-PA [Aedes aegypti] 124487747 EF091969.1 234 1.21728e-116 Maconellicoccus hirsutus clone WHMH3794 putative T-complex protein 1 subunit gamma mRNA, partial cds K09495 CCT3, TRIC5 T-complex protein 1 subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K09495 P48605 2177 3.1e-243 T-complex protein 1 subunit gamma OS=Drosophila melanogaster GN=Cctgamma PE=2 SV=2 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0005737 cytoplasm KOG0364 Chaperonin complex component, TCP-1 gamma subunit (CCT3) Cluster-8309.43854 BP_3 510.77 19.52 1553 646714773 KDR18627.1 221 2.4e-15 hypothetical protein L798_06607 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43855 BP_3 94.85 0.72 6630 478255041 ENN75273.1 1173 4.1e-125 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 658861642 XM_008415365.1 133 3.51341e-60 PREDICTED: Poecilia reticulata phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 1058 3.7e-113 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF00520//PF15461//PF01409 Ion transport protein//Beta-carotene 15,15'-dioxygenase//tRNA synthetases class II core domain (F) GO:0006418//GO:0043039//GO:0055114//GO:0006811//GO:0055085 tRNA aminoacylation for protein translation//tRNA aminoacylation//oxidation-reduction process//ion transport//transmembrane transport GO:0005216//GO:0004812//GO:0005524//GO:0016702//GO:0000049 ion channel activity//aminoacyl-tRNA ligase activity//ATP binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//tRNA binding GO:0016020//GO:0005737 membrane//cytoplasm KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.43857 BP_3 18.18 0.37 2652 91076592 XP_968333.1 932 1.5e-97 PREDICTED: charged multivesicular body protein 5 [Tribolium castaneum]>gi|270002380|gb|EEZ98827.1| hypothetical protein TcasGA2_TC004434 [Tribolium castaneum] 642912650 XM_963240.2 181 2.89514e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K12198 CHMP5, VPS60 charged multivesicular body protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12198 Q9VVI9 706 9.7e-73 Charged multivesicular body protein 5 OS=Drosophila melanogaster GN=Vps60 PE=1 SV=2 PF04111//PF16326//PF05531//PF04632//PF03357//PF04871//PF01920//PF02252//PF00091//PF07544//PF00462 Autophagy protein Apg6//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Fusaric acid resistance protein family//Snf7//Uso1 / p115 like vesicle tethering protein, C terminal region//Prefoldin subunit//Proteasome activator pa28 beta subunit//Tubulin/FtsZ family, GTPase domain//RNA polymerase II transcription mediator complex subunit 9//Glutaredoxin GO:0006457//GO:0045454//GO:0006886//GO:0006810//GO:0006914//GO:0006118//GO:0006357//GO:0015031//GO:0007034 protein folding//cell redox homeostasis//intracellular protein transport//transport//autophagy//obsolete electron transport//regulation of transcription from RNA polymerase II promoter//protein transport//vacuolar transport GO:0003677//GO:0001104//GO:0015035//GO:0009055//GO:0003924//GO:0008565//GO:0051082 DNA binding//RNA polymerase II transcription cofactor activity//protein disulfide oxidoreductase activity//electron carrier activity//GTPase activity//protein transporter activity//unfolded protein binding GO:0005886//GO:0016592//GO:0016020//GO:0019028//GO:0008537//GO:0005737//GO:0016272 plasma membrane//mediator complex//membrane//viral capsid//proteasome activator complex//cytoplasm//prefoldin complex KOG1655 Protein involved in vacuolar protein sorting Cluster-8309.43859 BP_3 1801.01 15.74 5808 642917952 XP_008198956.1 1655 4.7e-181 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 728 6.0e-75 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.4386 BP_3 8.00 1.29 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43860 BP_3 5.20 0.79 607 546675135 ERL86379.1 330 2.1e-28 hypothetical protein D910_03787, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43861 BP_3 13.50 0.41 1883 642913237 XP_008201451.1 545 7.8e-53 PREDICTED: zinc finger protein 830 [Tribolium castaneum] 828206332 XM_012701468.1 44 2.94068e-11 PREDICTED: Hydra vulgaris zinc finger protein 830-like (LOC100205964), mRNA K13104 ZNF830, CCDC16 zinc finger protein 830 http://www.genome.jp/dbget-bin/www_bget?ko:K13104 Q6DJ13 207 5.0e-15 Zinc finger protein 830 OS=Xenopus tropicalis GN=znf830 PE=2 SV=1 PF15898//PF16525 cGMP-dependent protein kinase interacting domain//Haemophore, haem-binding -- -- GO:0019901//GO:0020037 protein kinase binding//heme binding -- -- KOG3032 Uncharacterized conserved protein Cluster-8309.43862 BP_3 62.06 0.79 4071 642930006 XP_008196062.1 305 1.1e-24 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 1.2e-18 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43863 BP_3 581.84 8.88 3449 91086943 XP_972716.1 828 2.2e-85 PREDICTED: G patch domain-containing protein 4 [Tribolium castaneum]>gi|270010496|gb|EFA06944.1| hypothetical protein TcasGA2_TC009895 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 437 2.0e-41 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 PF08188//PF01585 Spermatozal protamine family//G-patch domain GO:0035092 sperm chromatin condensation GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0000228 nuclear chromosome KOG1212 Amidases Cluster-8309.43865 BP_3 1492.49 6.48 11389 642920053 XP_008192184.1 1927 2.6e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.85285e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.8e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF00341//PF13673//PF00159//PF02297//PF08159//PF03822//PF08445//PF00583//PF13508 PDGF/VEGF domain//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide//Cytochrome oxidase c subunit VIb//NUC153 domain//NAF domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0015992//GO:0006123//GO:0007165//GO:0042967//GO:0040007//GO:0008283 proton transport//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//acyl-carrier-protein biosynthetic process//growth//cell proliferation GO:0016747//GO:0004129//GO:0008083//GO:0008080//GO:0005179 transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity//growth factor activity//N-acetyltransferase activity//hormone activity GO:0005739//GO:0016020//GO:0005576//GO:0005634//GO:0045277 mitochondrion//membrane//extracellular region//nucleus//respiratory chain complex IV KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.43866 BP_3 540.82 9.07 3165 478254712 ENN74953.1 1280 7.7e-138 hypothetical protein YQE_08530, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 1251 7.3e-136 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF00722//PF15886 Glycosyl hydrolases family 16//Carbohydrate binding domain (family 32) GO:0005975 carbohydrate metabolic process GO:0004553//GO:0030246 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding -- -- -- -- Cluster-8309.43867 BP_3 65.51 1.40 2544 478254712 ENN74953.1 610 3.1e-60 hypothetical protein YQE_08530, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 564 2.7e-56 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF00722//PF15886 Glycosyl hydrolases family 16//Carbohydrate binding domain (family 32) GO:0005975 carbohydrate metabolic process GO:0004553//GO:0030246 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding -- -- -- -- Cluster-8309.43868 BP_3 573.95 4.10 7032 546685725 ERL95180.1 4192 0.0e+00 hypothetical protein D910_12448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.5e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.4387 BP_3 57.83 1.46 2206 564248485 XP_006263331.1 807 3.8e-83 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 740 9.2e-77 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF02892//PF07776//PF16622//PF00096//PF13465 C2H2-type zinc finger//BED zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.43871 BP_3 436.57 9.93 2410 478257950 ENN78088.1 1858 5.6e-205 hypothetical protein YQE_05242, partial [Dendroctonus ponderosae] -- -- -- -- -- K14805 DDX24, MAK5 ATP-dependent RNA helicase DDX24/MAK5 http://www.genome.jp/dbget-bin/www_bget?ko:K14805 Q9ESV0 1075 1.4e-115 ATP-dependent RNA helicase DDX24 OS=Mus musculus GN=Ddx24 PE=1 SV=2 PF06955//PF09798//PF08040//PF00270 Xyloglucan endo-transglycosylase (XET) C-terminus//DNA damage checkpoint protein//MNLL subunit//DEAD/DEAH box helicase GO:0006073//GO:0006118//GO:0000077 cellular glucan metabolic process//obsolete electron transport//DNA damage checkpoint GO:0016762//GO:0003676//GO:0003954//GO:0005524 xyloglucan:xyloglucosyl transferase activity//nucleic acid binding//NADH dehydrogenase activity//ATP binding GO:0005739//GO:0048046//GO:0005618 mitochondrion//apoplast//cell wall KOG0347 RNA helicase Cluster-8309.43872 BP_3 546.54 10.87 2715 91079112 XP_975371.1 1029 8.5e-109 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 1.3e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF04879//PF16760//PF03423//PF03370 Molybdopterin oxidoreductase Fe4S4 domain//Starch/carbohydrate-binding module (family 53)//Carbohydrate binding domain (family 25)//Carbohydrate/starch-binding module (family 21) GO:0055114 oxidation-reduction process GO:2001070//GO:0005515//GO:0016491 starch binding//protein binding//oxidoreductase activity -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.43873 BP_3 70.26 1.38 2746 91079112 XP_975371.1 1029 8.6e-109 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 1.3e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF03370//PF03423//PF16760 Carbohydrate/starch-binding module (family 21)//Carbohydrate binding domain (family 25)//Starch/carbohydrate-binding module (family 53) -- -- GO:2001070//GO:0005515 starch binding//protein binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.43874 BP_3 1255.29 9.43 6707 642920336 XP_008192303.1 1655 5.4e-181 PREDICTED: zinc finger CCCH domain-containing protein 14 isoform X1 [Tribolium castaneum]>gi|270005252|gb|EFA01700.1| hypothetical protein TcasGA2_TC007276 [Tribolium castaneum] 462358939 APGK01029925.1 99 2.82662e-41 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- Q5TYQ8 389 1.4e-35 Zinc finger CCCH domain-containing protein 14 OS=Danio rerio GN=zc3h14 PE=2 SV=1 PF03595//PF01480//PF05830 Voltage-dependent anion channel//PWI domain//Nodulation protein Z (NodZ) GO:0006397//GO:0009312//GO:0055085//GO:0009877 mRNA processing//oligosaccharide biosynthetic process//transmembrane transport//nodulation GO:0016758 transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane KOG3702 Nuclear polyadenylated RNA binding protein Cluster-8309.43879 BP_3 358.81 5.62 3367 237681208 NP_001153741.1 1279 1.1e-137 cleavage and polyadenylation specific factor 4, 30kDa [Tribolium castaneum]>gi|270004678|gb|EFA01126.1| hypothetical protein TcasGA2_TC010339 [Tribolium castaneum] 751792985 XM_011207858.1 143 4.90216e-66 PREDICTED: Bactrocera dorsalis cleavage and polyadenylation specificity factor subunit 4 (LOC105228160), mRNA K14404 CPSF4, YTH1 cleavage and polyadenylation specificity factor subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14404 Q9VPT8 848 4.2e-89 Cleavage and polyadenylation specificity factor subunit 4 OS=Drosophila melanogaster GN=Clp PE=1 SV=1 PF03943//PF00642//PF00098 TAP C-terminal domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Zinc knuckle GO:0051028 mRNA transport GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.4388 BP_3 74.70 2.01 2085 564248485 XP_006263331.1 816 3.2e-84 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 755 1.6e-78 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF16622//PF07776//PF13912//PF02892//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.43880 BP_3 213.62 2.08 5244 478255570 ENN75787.1 730 7.7e-74 hypothetical protein YQE_07744, partial [Dendroctonus ponderosae]>gi|546682060|gb|ERL92046.1| hypothetical protein D910_09368 [Dendroctonus ponderosae] 642913709 XM_008202908.1 121 1.30082e-53 PREDICTED: Tribolium castaneum acyl-CoA desaturase 1 (LOC662865), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O00767 550 2.3e-54 Acyl-CoA desaturase OS=Homo sapiens GN=SCD PE=1 SV=2 PF00487//PF14583 Fatty acid desaturase//Oligogalacturonate lyase GO:0006629//GO:0045490 lipid metabolic process//pectin catabolic process GO:0047487 oligogalacturonide lyase activity -- -- KOG1600 Fatty acid desaturase Cluster-8309.43881 BP_3 1296.09 7.06 9145 646710408 KDR15927.1 1190 6.1e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.79975e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.8e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.43882 BP_3 26.07 0.36 3810 91085981 XP_971976.1 3595 0.0e+00 PREDICTED: cullin-1 [Tribolium castaneum]>gi|642927556|ref|XP_008195314.1| PREDICTED: cullin-1 [Tribolium castaneum] -- -- -- -- -- K03347 CUL1, CDC53 cullin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03347 Q9WTX6 3029 0.0e+00 Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1 PF03965//PF00888 Penicillinase repressor//Cullin family GO:0045892//GO:0006511 negative regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process GO:0031625//GO:0003677 ubiquitin protein ligase binding//DNA binding -- -- KOG2166 Cullins Cluster-8309.43883 BP_3 359.86 5.74 3311 91092074 XP_971115.1 2158 1.3e-239 PREDICTED: uncharacterized protein LOC659745 [Tribolium castaneum]>gi|270004682|gb|EFA01130.1| hypothetical protein TcasGA2_TC010343 [Tribolium castaneum] 642917993 XM_966022.2 289 3.32714e-147 PREDICTED: Tribolium castaneum uncharacterized LOC659745 (LOC659745), mRNA K10480 BTBD8 BTB/POZ domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10480 Q5XKL5 386 1.5e-35 BTB/POZ domain-containing protein 8 OS=Homo sapiens GN=BTBD8 PE=2 SV=2 PF00651//PF15952 BTB/POZ domain//Enhancer of split M4 family GO:0007423//GO:0007219 sensory organ development//Notch signaling pathway GO:0005515 protein binding -- -- KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.43884 BP_3 25.29 0.46 2947 91083583 XP_968366.1 950 1.3e-99 PREDICTED: adenosylhomocysteinase [Tribolium castaneum]>gi|270007826|gb|EFA04274.1| hypothetical protein TcasGA2_TC014564 [Tribolium castaneum] 751460631 XM_011186787.1 162 1.17439e-76 PREDICTED: Bactrocera cucurbitae adenosylhomocysteinase (LOC105213739), mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q27580 872 6.1e-92 Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=2 SV=2 PF02826//PF02254//PF11744//PF01175//PF05221//PF00208 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//TrkA-N domain//Aluminium activated malate transporter//Urocanase//S-adenosyl-L-homocysteine hydrolase//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GO:0006813//GO:0015743//GO:0055114//GO:0006555//GO:0006520//GO:0006547//GO:0006730 potassium ion transport//malate transport//oxidation-reduction process//methionine metabolic process//cellular amino acid metabolic process//histidine metabolic process//one-carbon metabolic process GO:0051287//GO:0004013//GO:0016491//GO:0000166//GO:0016153 NAD binding//adenosylhomocysteinase activity//oxidoreductase activity//nucleotide binding//urocanate hydratase activity -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.43885 BP_3 6.20 0.43 985 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43889 BP_3 1211.05 33.05 2058 332376366 AEE63323.1 1176 5.8e-126 unknown [Dendroctonus ponderosae]>gi|478253695|gb|ENN73994.1| hypothetical protein YQE_09384, partial [Dendroctonus ponderosae]>gi|546679604|gb|ERL90045.1| hypothetical protein D910_07403 [Dendroctonus ponderosae] 195403178 XM_002060136.1 104 1.42536e-44 Drosophila virilis GJ18493 (Dvir\GJ18493), mRNA -- -- -- -- Q9VXK0 976 3.7e-104 Protein NipSnap OS=Drosophila melanogaster GN=Nipsnap PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2883 NIPSNAP1 protein Cluster-8309.4389 BP_3 6.80 0.66 791 836000512 XP_004573587.2 367 1.4e-32 PREDICTED: uncharacterized protein LOC101484584 [Maylandia zebra] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 349 7.2e-32 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF02892//PF13912//PF01428//PF16622//PF02176//PF00096//PF00130//PF06467 Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//TRAF-type zinc finger//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//MYM-type Zinc finger with FCS sequence motif GO:0035556 intracellular signal transduction GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.43895 BP_3 1023.85 23.25 2414 91088593 XP_967390.1 873 9.2e-91 PREDICTED: low density lipoprotein receptor adapter protein 1 [Tribolium castaneum]>gi|270012267|gb|EFA08715.1| hypothetical protein TcasGA2_TC006386 [Tribolium castaneum] -- -- -- -- -- K12474 LDLRAP1, ARH low density lipoprotein receptor adapter protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12474 Q67FQ3 337 5.4e-30 Low density lipoprotein receptor adapter protein 1-B OS=Xenopus laevis GN=ldlrap1-b PE=1 SV=1 PF00640//PF08416//PF14719 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43896 BP_3 504.15 2.38 10499 270003689 EFA00137.1 2104 7.3e-233 hypothetical protein TcasGA2_TC002957 [Tribolium castaneum] 642916224 XM_008192715.1 305 1.35515e-155 PREDICTED: Tribolium castaneum uncharacterized LOC662985 (LOC662985), mRNA -- -- -- -- Q9V5L3 504 1.0e-48 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF02459//PF00631//PF00067//PF00439 Adenoviral DNA terminal protein//GGL domain//Cytochrome P450//Bromodomain GO:0007165//GO:0006260//GO:0007186//GO:0055114 signal transduction//DNA replication//G-protein coupled receptor signaling pathway//oxidation-reduction process GO:0003677//GO:0016705//GO:0005515//GO:0004871//GO:0005506//GO:0020037 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//protein binding//signal transducer activity//iron ion binding//heme binding GO:0005834 heterotrimeric G-protein complex KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.43897 BP_3 277.15 5.94 2541 189233738 XP_971576.2 1678 4.4e-184 PREDICTED: xaa-Pro dipeptidase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K14213 PEPD Xaa-Pro dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K14213 P12955 1250 7.7e-136 Xaa-Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 SV=3 PF05195 Aminopeptidase P, N-terminal domain -- -- GO:0030145//GO:0004177 manganese ion binding//aminopeptidase activity -- -- KOG2737 Putative metallopeptidase Cluster-8309.43898 BP_3 316.24 5.15 3250 91076670 XP_971562.1 2445 6.5e-273 PREDICTED: ATP-binding cassette sub-family F member 1 [Tribolium castaneum]>gi|270002367|gb|EEZ98814.1| hypothetical protein TcasGA2_TC004420 [Tribolium castaneum] 195480796 XM_002101360.1 207 1.25157e-101 Drosophila yakuba GE15656 (Dyak\GE15656), partial mRNA K06184 ABCF1 ATP-binding cassette, subfamily F, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06184 Q767L0 1760 7.2e-195 ATP-binding cassette sub-family F member 1 OS=Sus scrofa GN=ABCF1 PE=3 SV=1 PF03193//PF00005//PF06003//PF03938//PF01008//PF00910//PF13304//PF01926//PF00004//PF07213 Protein of unknown function, DUF258//ABC transporter//Survival motor neuron protein (SMN)//Outer membrane protein (OmpH-like)//Initiation factor 2 subunit family//RNA helicase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//DAP10 membrane protein GO:0050776//GO:0044237//GO:0006200//GO:0007165//GO:0006397//GO:0014068 regulation of immune response//cellular metabolic process//obsolete ATP catabolic process//signal transduction//mRNA processing//positive regulation of phosphatidylinositol 3-kinase signaling GO:0005102//GO:0016887//GO:0051082//GO:0003924//GO:0043548//GO:0005524//GO:0003724//GO:0005525//GO:0003723 receptor binding//ATPase activity//unfolded protein binding//GTPase activity//phosphatidylinositol 3-kinase binding//ATP binding//RNA helicase activity//GTP binding//RNA binding GO:0005737//GO:0016020//GO:0005634 cytoplasm//membrane//nucleus KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b Cluster-8309.43899 BP_3 10.00 0.72 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04061//PF00335 ORMDL family//Tetraspanin family -- -- -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.4390 BP_3 70.67 1.83 2157 564248485 XP_006263331.1 816 3.4e-84 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 755 1.6e-78 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00075//PF00096//PF13465//PF02892//PF13912//PF07776//PF16622 RNase H//Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type GO:0051252 regulation of RNA metabolic process GO:0008270//GO:0003676//GO:0003677//GO:0004523//GO:0046872 zinc ion binding//nucleic acid binding//DNA binding//RNA-DNA hybrid ribonuclease activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.43900 BP_3 161.22 0.93 8647 478253916 ENN74208.1 1517 7.0e-165 hypothetical protein YQE_09181, partial [Dendroctonus ponderosae] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9NP71 521 8.9e-51 Carbohydrate-responsive element-binding protein OS=Homo sapiens GN=MLXIPL PE=1 SV=1 PF00595//PF13180//PF09726//PF10186//PF00170//PF00010 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Transmembrane protein//Vacuolar sorting 38 and autophagy-related subunit 14//bZIP transcription factor//Helix-loop-helix DNA-binding domain GO:0010508//GO:0006355 positive regulation of autophagy//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0046983//GO:0005515 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein dimerization activity//protein binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane KOG3582 Mlx interactors and related transcription factors Cluster-8309.43901 BP_3 318.02 12.13 1555 642933162 XP_974056.2 1933 7.2e-214 PREDICTED: ubiquitin carboxyl-terminal hydrolase nonstop isoform X2 [Tribolium castaneum] -- -- -- -- -- K11366 USP22_27_51, UBP8 ubiquitin carboxyl-terminal hydrolase 22/27/51 http://www.genome.jp/dbget-bin/www_bget?ko:K11366 Q9VVR1 1294 3.7e-141 Ubiquitin carboxyl-terminal hydrolase nonstop OS=Drosophila melanogaster GN=not PE=1 SV=3 PF02148//PF00443 Zn-finger in ubiquitin-hydrolases and other protein//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0008270 ubiquitinyl hydrolase activity//zinc ion binding -- -- KOG1867 Ubiquitin-specific protease Cluster-8309.43902 BP_3 38.94 0.93 2313 478257769 ENN77912.1 1776 1.7e-195 hypothetical protein YQE_05589, partial [Dendroctonus ponderosae] 118344591 NM_001078595.1 107 3.44979e-46 Takifugu rubripes transmembrane protein 57 (tmem57), mRNA >gnl|BL_ORD_ID|675048 Takifugu rubripes macoilin-2 mRNA, complete cds -- -- -- -- Q2TLY1 912 1.1e-96 Macoilin-2 OS=Danio rerio GN=tmem57b PE=2 SV=1 PF09726//PF04508 Transmembrane protein//Viral A-type inclusion protein repeat GO:0016032 viral process -- -- GO:0016021 integral component of membrane KOG1821 Uncharacterized conserved protein Cluster-8309.43903 BP_3 670.60 6.23 5481 642935990 XP_008198259.1 4380 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1884 5.1e-209 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.43905 BP_3 1776.28 16.32 5537 642927835 XP_972081.2 781 9.9e-80 PREDICTED: LOW QUALITY PROTEIN: probable glucosamine 6-phosphate N-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00621 GNPNAT1, GNA1 glucosamine-phosphate N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00621 Q9VAI0 611 2.1e-61 Probable glucosamine 6-phosphate N-acetyltransferase OS=Drosophila melanogaster GN=CG1969 PE=2 SV=1 PF13673//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3396 Glucosamine-phosphate N-acetyltransferase Cluster-8309.43906 BP_3 6.00 12.71 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43907 BP_3 383.01 6.39 3180 91088615 XP_974002.1 834 4.0e-86 PREDICTED: sepiapterin reductase [Tribolium castaneum]>gi|270012265|gb|EFA08713.1| hypothetical protein TcasGA2_TC006384 [Tribolium castaneum] -- -- -- -- -- K00072 SPR sepiapterin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00072 P35270 313 4.3e-27 Sepiapterin reductase OS=Homo sapiens GN=SPR PE=1 SV=1 PF00769//PF05130//PF12242//PF00106 Ezrin/radixin/moesin family//FlgN protein//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase GO:0044780//GO:0008152//GO:0055114 bacterial-type flagellum assembly//metabolic process//oxidation-reduction process GO:0008092//GO:0016491 cytoskeletal protein binding//oxidoreductase activity GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG1204 Predicted dehydrogenase Cluster-8309.43908 BP_3 107.00 5.19 1312 13625795 AAK35160.1 181 8.7e-11 defensin 1 precursor [Acalolepta luxuriosa] -- -- -- -- -- -- -- -- -- Q27023 157 2.2e-09 Tenecin-1 OS=Tenebrio molitor PE=1 SV=1 PF01097 Arthropod defensin GO:0006952 defense response -- -- -- -- -- -- Cluster-8309.43910 BP_3 20.98 0.44 2611 91082797 XP_967743.1 383 6.6e-34 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BXC6 243 4.6e-19 COMM domain-containing protein 2 OS=Mus musculus GN=Commd2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43911 BP_3 2238.24 7.80 14122 642938921 XP_008195601.1 3295 0.0e+00 PREDICTED: PHD finger protein rhinoceros [Tribolium castaneum] 642938920 XM_008197379.1 365 0 PREDICTED: Tribolium castaneum PHD finger protein rhinoceros (LOC659824), mRNA -- -- -- -- Q7YZH1 1379 4.7e-150 PHD finger protein rhinoceros OS=Drosophila melanogaster GN=rno PE=1 SV=1 PF14560//PF00628//PF00312//PF02214//PF00130//PF02136//PF03708 Ubiquitin-like domain//PHD-finger//Ribosomal protein S15//BTB/POZ domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Nuclear transport factor 2 (NTF2) domain//Avian retrovirus envelope protein, gp85 GO:0051260//GO:0006412//GO:0006810//GO:0035556//GO:0042254 protein homooligomerization//translation//transport//intracellular signal transduction//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0019031//GO:0005840//GO:0005622 viral envelope//ribosome//intracellular KOG3840 Uncharaterized conserved protein, contains BTB/POZ domain Cluster-8309.43916 BP_3 432.38 3.34 6537 642930787 XP_008196091.1 3440 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.5e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF08069//PF08211//PF02217//PF07531//PF01428//PF00383 Ribosomal S13/S15 N-terminal domain//Cytidine and deoxycytidylate deaminase zinc-binding region//Origin of replication binding protein//NHR1 homology to TAF//AN1-like Zinc finger//Cytidine and deoxycytidylate deaminase zinc-binding region GO:0006260//GO:0006355//GO:0046087//GO:0042254//GO:0006206//GO:0009972//GO:0006807//GO:0006412 DNA replication//regulation of transcription, DNA-templated//cytidine metabolic process//ribosome biogenesis//pyrimidine nucleobase metabolic process//cytidine deamination//nitrogen compound metabolic process//translation GO:0003735//GO:0008270//GO:0003700//GO:0003688//GO:0004126 structural constituent of ribosome//zinc ion binding//transcription factor activity, sequence-specific DNA binding//DNA replication origin binding//cytidine deaminase activity GO:0005840//GO:0046809//GO:0005667 ribosome//replication compartment//transcription factor complex KOG3183 Predicted Zn-finger protein Cluster-8309.43917 BP_3 395.84 2.67 7443 642930787 XP_008196091.1 3584 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.7e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF16711//PF02217//PF07531//PF00383//PF01428//PF08211//PF08069 Actin-binding domain of plant-specific actin-binding protein//Origin of replication binding protein//NHR1 homology to TAF//Cytidine and deoxycytidylate deaminase zinc-binding region//AN1-like Zinc finger//Cytidine and deoxycytidylate deaminase zinc-binding region//Ribosomal S13/S15 N-terminal domain GO:0042254//GO:0046087//GO:0006355//GO:0006260//GO:0006412//GO:0006807//GO:0009972//GO:0006206 ribosome biogenesis//cytidine metabolic process//regulation of transcription, DNA-templated//DNA replication//translation//nitrogen compound metabolic process//cytidine deamination//pyrimidine nucleobase metabolic process GO:0003779//GO:0003688//GO:0003700//GO:0003735//GO:0008270//GO:0004126 actin binding//DNA replication origin binding//transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome//zinc ion binding//cytidine deaminase activity GO:0005840//GO:0005667//GO:0046809 ribosome//transcription factor complex//replication compartment KOG3183 Predicted Zn-finger protein Cluster-8309.43919 BP_3 174.85 4.20 2297 91081833 XP_974716.1 1272 4.8e-137 PREDICTED: replication factor C subunit 4 [Tribolium castaneum]>gi|270006308|gb|EFA02756.1| hypothetical protein TcasGA2_TC008489 [Tribolium castaneum] 156849228 XM_001647445.1 73 2.72413e-27 Vanderwaltozyma polyspora DSM 70294 hypothetical protein (Kpol_1018p177) partial mRNA K10755 RFC2_4 replication factor C subunit 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10755 Q99J62 913 8.3e-97 Replication factor C subunit 4 OS=Mus musculus GN=Rfc4 PE=1 SV=1 PF01443//PF05496//PF07728//PF06144//PF00004//PF01637//PF02562//PF04851//PF00270 Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//DNA polymerase III, delta subunit//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0006260//GO:0006310//GO:0006281 DNA replication//DNA recombination//DNA repair GO:0009378//GO:0017111//GO:0003676//GO:0016887//GO:0003887//GO:0003677//GO:0016787//GO:0005524 four-way junction helicase activity//nucleoside-triphosphatase activity//nucleic acid binding//ATPase activity//DNA-directed DNA polymerase activity//DNA binding//hydrolase activity//ATP binding GO:0042575//GO:0009360//GO:0005657//GO:0009379 DNA polymerase complex//DNA polymerase III complex//replication fork//Holliday junction helicase complex KOG0989 Replication factor C, subunit RFC4 Cluster-8309.43922 BP_3 191.57 8.88 1332 478250432 ENN70927.1 600 2.3e-59 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 510 2.6e-50 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00522//PF00656 VPR/VPX protein//Caspase domain GO:0006508//GO:0019058 proteolysis//viral life cycle GO:0004197 cysteine-type endopeptidase activity GO:0042025 host cell nucleus -- -- Cluster-8309.43924 BP_3 43.21 1.78 1464 91089723 XP_975024.1 1131 6.8e-121 PREDICTED: ATPase family AAA domain-containing protein 1-B [Tribolium castaneum]>gi|270011311|gb|EFA07759.1| hypothetical protein TcasGA2_TC005313 [Tribolium castaneum] 768421023 XM_011553001.1 182 4.39542e-88 PREDICTED: Plutella xylostella ATPase family AAA domain-containing protein 1-A (LOC105383005), mRNA -- -- -- -- Q503W7 873 2.3e-92 ATPase family AAA domain-containing protein 1-B OS=Danio rerio GN=atad1b PE=2 SV=2 PF07724//PF00004//PF06068//PF00158//PF05496//PF07728//PF01695//PF14532//PF00910//PF02367//PF06414//PF02562 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//TIP49 C-terminus//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//RNA helicase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein GO:0006281//GO:0006355//GO:0002949//GO:0006310 DNA repair//regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification//DNA recombination GO:0008134//GO:0005524//GO:0016301//GO:0016887//GO:0003678//GO:0003723//GO:0009378//GO:0017111//GO:0003724 transcription factor binding//ATP binding//kinase activity//ATPase activity//DNA helicase activity//RNA binding//four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity GO:0009379//GO:0005667//GO:0005657 Holliday junction helicase complex//transcription factor complex//replication fork KOG0737 AAA+-type ATPase Cluster-8309.43925 BP_3 214.39 2.95 3792 642919490 XP_008191893.1 2883 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum]>gi|642919492|ref|XP_008191894.1| PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43927 BP_3 23.28 0.37 3330 91089951 XP_973444.1 2134 7.7e-237 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013551|gb|EFA09999.1| hypothetical protein TcasGA2_TC012169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q55EH8 694 3.0e-71 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF00931//PF03193//PF00005//PF00006//PF13304//PF01061//PF01637 NB-ARC domain//Protein of unknown function, DUF258//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//AAA domain, putative AbiEii toxin, Type IV TA system//ABC-2 type transporter//Archaeal ATPase -- -- GO:0005525//GO:0005524//GO:0000166//GO:0016887//GO:0043531//GO:0003924 GTP binding//ATP binding//nucleotide binding//ATPase activity//ADP binding//GTPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.43928 BP_3 198.95 3.79 2822 91093803 XP_968404.1 863 1.6e-89 PREDICTED: inositol polyphosphate 1-phosphatase [Tribolium castaneum]>gi|270015932|gb|EFA12380.1| hypothetical protein TcasGA2_TC002087 [Tribolium castaneum] -- -- -- -- -- K01107 INPP1 inositol polyphosphate 1-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01107 P49442 655 8.4e-67 Inositol polyphosphate 1-phosphatase OS=Mus musculus GN=Inpp1 PE=2 SV=2 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.43929 BP_3 64.82 2.15 1745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14978 Mitochondrial ribosome protein 63 -- -- -- -- GO:0005761 mitochondrial ribosome -- -- Cluster-8309.43930 BP_3 49.55 0.41 6061 91082203 XP_972014.1 3263 0.0e+00 PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922206|ref|XP_008193062.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922209|ref|XP_008193063.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|270007229|gb|EFA03677.1| hypothetical protein TcasGA2_TC013779 [Tribolium castaneum] -- -- -- -- -- K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 O02466 665 1.3e-67 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF00069//PF03139//PF07714 Protein kinase domain//Vanadium/alternative nitrogenase delta subunit//Protein tyrosine kinase GO:0009399//GO:0019337//GO:0016310//GO:0006468//GO:0006807//GO:0055114 nitrogen fixation//tetrachloroethylene catabolic process//phosphorylation//protein phosphorylation//nitrogen compound metabolic process//oxidation-reduction process GO:0005524//GO:0000166//GO:0004672//GO:0016163 ATP binding//nucleotide binding//protein kinase activity//nitrogenase activity GO:0016610 nitrogenase complex KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.43931 BP_3 126.00 19.45 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43932 BP_3 2534.42 20.37 6288 642930675 XP_966843.2 4210 0.0e+00 PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 Q08470 2065 6.0e-230 Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura GN=l(2)gl PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.43934 BP_3 76.74 1.29 3154 649572315 NP_001280527.1 2838 0.0e+00 lethal(2) giant larvae protein homolog 1 [Tribolium castaneum]>gi|642930673|ref|XP_008199983.1| PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X1 [Tribolium castaneum]>gi|270012677|gb|EFA09125.1| hypothetical protein TcasGA2_TC015986 [Tribolium castaneum]>gi|625293659|gb|AHY24027.1| lethal giant larvae [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 Q08470 1450 6.1e-159 Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura GN=l(2)gl PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.43935 BP_3 19.29 0.36 2863 642932086 XP_008196851.1 1247 4.7e-134 PREDICTED: solute carrier family 25 member 36-A isoform X2 [Tribolium castaneum] -- -- -- -- -- K15116 SLC25A33_36, RIM2 solute carrier family 25, member 33/36 http://www.genome.jp/dbget-bin/www_bget?ko:K15116 Q6DG32 810 9.1e-85 Solute carrier family 25 member 36-A OS=Danio rerio GN=slc25a36a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0757 Mitochondrial carrier protein - Rim2p/Mrs12p Cluster-8309.43936 BP_3 259.35 4.76 2917 91088711 XP_975115.1 1328 1.9e-143 PREDICTED: solute carrier family 25 member 36-A isoform X1 [Tribolium castaneum]>gi|270012292|gb|EFA08740.1| hypothetical protein TcasGA2_TC006415 [Tribolium castaneum] -- -- -- -- -- K15116 SLC25A33_36, RIM2 solute carrier family 25, member 33/36 http://www.genome.jp/dbget-bin/www_bget?ko:K15116 Q6DG32 745 3.2e-77 Solute carrier family 25 member 36-A OS=Danio rerio GN=slc25a36a PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0757 Mitochondrial carrier protein - Rim2p/Mrs12p Cluster-8309.43938 BP_3 339.65 2.25 7557 270001017 EEZ97464.1 919 1.3e-95 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 726 1.3e-74 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF03540//PF02137//PF07297 Transcription initiation factor TFIID 23-30kDa subunit//Adenosine-deaminase (editase) domain//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) GO:0006144//GO:0009059//GO:0006352//GO:0006807//GO:0006396 purine nucleobase metabolic process//macromolecule biosynthetic process//DNA-templated transcription, initiation//nitrogen compound metabolic process//RNA processing GO:0003723//GO:0004000 RNA binding//adenosine deaminase activity GO:0005634//GO:0030176 nucleus//integral component of endoplasmic reticulum membrane KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.43939 BP_3 112.08 0.63 8866 270001017 EEZ97464.1 369 9.4e-32 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 337 2.0e-29 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF02137//PF07297 Adenosine-deaminase (editase) domain//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) GO:0006396//GO:0009059//GO:0006807//GO:0006144 RNA processing//macromolecule biosynthetic process//nitrogen compound metabolic process//purine nucleobase metabolic process GO:0004000//GO:0003723 adenosine deaminase activity//RNA binding GO:0030176 integral component of endoplasmic reticulum membrane KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.43940 BP_3 822.03 9.37 4521 91079889 XP_968047.1 4005 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 3.88904e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 1.4e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF00443//PF00240//PF14560 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin family//Ubiquitin-like domain GO:0016579 protein deubiquitination GO:0005515//GO:0036459 protein binding//ubiquitinyl hydrolase activity -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.43941 BP_3 1363.25 8.27 8234 91079889 XP_968047.1 4173 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 7.10556e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 2.5e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF00443//PF00240//PF14560 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin family//Ubiquitin-like domain GO:0016579 protein deubiquitination GO:0036459//GO:0005515 ubiquitinyl hydrolase activity//protein binding -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.43942 BP_3 313.65 2.68 5941 642925021 XP_008194139.1 3725 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X3 [Tribolium castaneum] 462328174 APGK01040787.1 46 7.26165e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 6.1e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.43944 BP_3 446.64 12.56 2006 91077554 XP_972108.1 1153 2.6e-123 PREDICTED: 39S ribosomal protein L2, mitochondrial [Tribolium castaneum]>gi|270001586|gb|EEZ98033.1| hypothetical protein TcasGA2_TC000434 [Tribolium castaneum] -- -- -- -- -- K02886 RP-L2, MRPL2, rplB large subunit ribosomal protein L2 http://www.genome.jp/dbget-bin/www_bget?ko:K02886 Q498T4 482 6.9e-47 39S ribosomal protein L2, mitochondrial OS=Rattus norvegicus GN=Mrpl2 PE=2 SV=1 PF00181//PF03947 Ribosomal Proteins L2, RNA binding domain//Ribosomal Proteins L2, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0438 Mitochondrial/chloroplast ribosomal protein L2 Cluster-8309.43949 BP_3 543.17 15.05 2031 478255214 ENN75443.1 689 1.7e-69 hypothetical protein YQE_07994, partial [Dendroctonus ponderosae]>gi|546675119|gb|ERL86366.1| hypothetical protein D910_03774 [Dendroctonus ponderosae] -- -- -- -- -- K17499 PPM1G, PP2CG protein phosphatase 1G http://www.genome.jp/dbget-bin/www_bget?ko:K17499 Q7K4Q5 586 6.1e-59 Probable protein phosphatase CG10417 OS=Drosophila melanogaster GN=CG10417 PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.43950 BP_3 604.67 16.74 2033 167444210 ABZ80666.1 1036 9.8e-110 tollip-like protein [Sitophilus zeamais] -- -- -- -- -- K05402 TOLLIP toll-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05402 A2RUW1 649 3.0e-66 Toll-interacting protein OS=Rattus norvegicus GN=Tollip PE=2 SV=1 PF02845//PF00168 CUE domain//C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43952 BP_3 488.52 4.73 5272 270007730 EFA04178.1 469 1.4e-43 hypothetical protein TcasGA2_TC014427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0D2 153 2.6e-08 Centrosomal protein of 295 kDa OS=Homo sapiens GN=CEP295 PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43957 BP_3 16.00 4.44 465 270297202 NP_001161902.1 515 5.8e-50 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 374 5.3e-35 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- GO:0008152 metabolic process GO:0033961 cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.43959 BP_3 133.20 1.38 4942 817011235 AKF11871.1 1486 1.6e-161 putative juvenile hormone epoxide hydrolase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 1230 3.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.4396 BP_3 43.49 1.75 1488 642918175 XP_008191397.1 1135 2.4e-121 PREDICTED: glycosyltransferase-like domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXN0 820 3.3e-86 Glycosyltransferase-like domain-containing protein 1-like OS=Drosophila melanogaster GN=CG15914 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43962 BP_3 67.15 0.82 4224 270000732 EEZ97179.1 1015 5.5e-107 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] 642937909 XM_008202132.1 151 2.20112e-70 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 399 6.1e-37 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.43963 BP_3 169.87 5.31 1835 91079236 XP_970901.1 1361 1.8e-147 PREDICTED: tubulin-specific chaperone E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KS0 795 3.2e-83 Tubulin-specific chaperone E OS=Bos taurus GN=TBCE PE=2 SV=1 PF00564//PF13855 PB1 domain//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG3207 Beta-tubulin folding cofactor E Cluster-8309.43964 BP_3 32.28 0.95 1932 270004984 EFA01432.1 746 3.9e-76 hypothetical protein TcasGA2_TC030612, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U378 462 1.4e-44 Tubulin-specific chaperone E OS=Danio rerio GN=tbce PE=2 SV=2 PF00564//PF13855//PF14560//PF00560 PB1 domain//Leucine rich repeat//Ubiquitin-like domain//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG3207 Beta-tubulin folding cofactor E Cluster-8309.43966 BP_3 208.47 2.14 4994 571522851 XP_006560648.1 2180 5.3e-242 PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X3 [Apis mellifera]>gi|572299843|ref|XP_006616037.1| PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X2 [Apis dorsata]>gi|820834524|ref|XP_012348863.1| PREDICTED: zinc finger SWIM domain-containing protein 8 isoform X2 [Apis florea] 195132728 XM_002010759.1 175 1.18691e-83 Drosophila mojavensis GI21737 (Dmoj\GI21737), mRNA -- -- -- -- A7E2V4 1086 1.6e-116 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3615 Uncharacterized conserved protein Cluster-8309.43968 BP_3 526.51 5.98 4538 642916588 XP_008191804.1 545 1.9e-52 PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum]>gi|642916590|ref|XP_008191810.1| PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12597 AIR1_2 protein AIR1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12597 A1L2T6 239 2.3e-18 Zinc finger CCHC domain-containing protein 7 OS=Xenopus laevis GN=zcchc7 PE=2 SV=2 PF06331 Transcription factor TFIIH complex subunit Tfb5 GO:0006289//GO:0006355 nucleotide-excision repair//regulation of transcription, DNA-templated -- -- GO:0000439 core TFIIH complex KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.43969 BP_3 45.55 0.44 5281 91076774 XP_973840.1 1189 4.6e-127 PREDICTED: autophagy protein 5 [Tribolium castaneum]>gi|270001850|gb|EEZ98297.1| hypothetical protein TcasGA2_TC000747 [Tribolium castaneum] 170060949 XM_001865993.1 65 1.76815e-22 Culex quinquefasciatus Autophagy-specific protein, mRNA K08339 ATG5 autophagy-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08339 Q9W3R7 857 6.0e-90 Autophagy protein 5 OS=Drosophila melanogaster GN=Atg5 PE=2 SV=2 PF06309//PF04106//PF07728 Torsin//Autophagy protein Apg5//AAA domain (dynein-related subfamily) GO:0006914 autophagy GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0005737 cytoplasm KOG2170 ATPase of the AAA+ superfamily Cluster-8309.43970 BP_3 80.56 5.67 977 546680730 ERL90956.1 961 2.3e-101 hypothetical protein D910_08298 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R599 496 8.0e-49 Translin-associated protein X OS=Macaca fascicularis GN=TSNAX PE=2 SV=1 PF01997 Translin family -- -- GO:0043565 sequence-specific DNA binding -- -- KOG3066 Translin-associated protein X Cluster-8309.43971 BP_3 210.42 4.27 2668 728417098 AIY68333.1 793 1.9e-81 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 522 2.1e-51 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.43974 BP_3 59.44 2.36 1507 642931467 XP_966826.3 924 7.0e-97 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q6PEM8 149 2.1e-08 Proton-coupled folate transporter OS=Mus musculus GN=Slc46a1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43975 BP_3 96.53 0.58 8290 642914685 XP_008190314.1 4543 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum] 695158202 XM_009508869.1 44 1.31246e-10 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 1636 4.4e-180 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 PF00069//PF07714//PF16656//PF00041 Protein kinase domain//Protein tyrosine kinase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497//GO:0006468 riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0046872//GO:0004672//GO:0003993//GO:0005515//GO:0005524 metal ion binding//protein kinase activity//acid phosphatase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.43976 BP_3 289.39 1.74 8296 642914685 XP_008190314.1 7291 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum] 695158202 XM_009508869.1 44 1.31341e-10 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 Q78DX7 2253 1.2e-251 Proto-oncogene tyrosine-protein kinase ROS OS=Mus musculus GN=Ros1 PE=1 SV=1 PF00069//PF07714//PF16656//PF00041 Protein kinase domain//Protein tyrosine kinase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0006468//GO:0019497 riboflavin metabolic process//protein phosphorylation//hexachlorocyclohexane metabolic process GO:0003993//GO:0004672//GO:0046872//GO:0005524//GO:0005515 acid phosphatase activity//protein kinase activity//metal ion binding//ATP binding//protein binding -- -- -- -- Cluster-8309.43977 BP_3 758.36 11.48 3477 478260834 ENN80486.1 1804 1.5e-198 hypothetical protein YQE_03090, partial [Dendroctonus ponderosae] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q5F364 1548 2.9e-170 Multidrug resistance-associated protein 1 OS=Gallus gallus GN=ABCC1 PE=2 SV=1 PF00664//PF01926//PF13304//PF00005//PF03193 ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.43981 BP_3 101.34 4.59 1356 270003787 EFA00235.1 713 1.9e-72 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 642915737 XM_008192562.1 189 5.21907e-92 PREDICTED: Tribolium castaneum kalirin (LOC656919), transcript variant X3, mRNA K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 Q0KL02 317 6.3e-28 Triple functional domain protein OS=Mus musculus GN=Trio PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.43982 BP_3 151.15 0.64 11723 642927139 XP_008195153.1 8604 0.0e+00 PREDICTED: talin-1 isoform X1 [Tribolium castaneum]>gi|642927141|ref|XP_008195154.1| PREDICTED: talin-1 isoform X1 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.78117e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01608//PF01044//PF02174//PF09141//PF01025 I/LWEQ domain//Vinculin family//PTB domain (IRS-1 type)//Talin, middle domain//GrpE GO:0007016//GO:0007165//GO:0006457//GO:0007155 cytoskeletal anchoring at plasma membrane//signal transduction//protein folding//cell adhesion GO:0003779//GO:0005158//GO:0042803//GO:0005200//GO:0051087//GO:0051015//GO:0000774 actin binding//insulin receptor binding//protein homodimerization activity//structural constituent of cytoskeleton//chaperone binding//actin filament binding//adenyl-nucleotide exchange factor activity GO:0005899//GO:0001726//GO:0005856//GO:0005925 insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.43984 BP_3 106.03 2.55 2296 478260883 ENN80520.1 505 4.1e-48 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IZR5 151 1.9e-08 CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Homo sapiens GN=CMTM4 PE=1 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane KOG4788 Members of chemokine-like factor super family and related proteins Cluster-8309.43987 BP_3 1057.85 13.18 4160 270013807 EFA10255.1 3315 0.0e+00 hypothetical protein TcasGA2_TC012455 [Tribolium castaneum] -- -- -- -- -- K04648 DCTN1 dynactin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04648 P13496 2104 1.2e-234 Dynactin subunit 1 OS=Drosophila melanogaster GN=Gl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0971 Microtubule-associated protein dynactin DCTN1/Glued Cluster-8309.43988 BP_3 1692.07 19.61 4451 642934746 XP_008197795.1 2989 0.0e+00 PREDICTED: dynactin subunit 1 [Tribolium castaneum] -- -- -- -- -- K04648 DCTN1 dynactin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04648 P13496 1855 9.5e-206 Dynactin subunit 1 OS=Drosophila melanogaster GN=Gl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0971 Microtubule-associated protein dynactin DCTN1/Glued Cluster-8309.43990 BP_3 144.44 2.04 3699 642927970 XP_972030.2 3284 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 255552749 XM_002517372.1 35 5.86839e-06 Ricinus communis mannosidase alpha class 2a, putative, mRNA K01231 MAN2 alpha-mannosidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01231 Q24451 1997 2.7e-222 Alpha-mannosidase 2 OS=Drosophila melanogaster GN=alpha-Man-II PE=1 SV=2 PF09261//PF01074//PF07748//PF08053 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain//Tryptophanase operon leader peptide GO:0031554//GO:0031556//GO:0006013//GO:0005975 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome//mannose metabolic process//carbohydrate metabolic process GO:0004553//GO:0004559//GO:0015923//GO:0008270 hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-mannosidase activity//mannosidase activity//zinc ion binding -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.43991 BP_3 4.97 0.31 1076 607357938 EZA52377.1 193 2.9e-12 hypothetical protein X777_08775, partial [Cerapachys biroi] 462299627 APGK01051253.1 52 5.92344e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43992 BP_3 777.46 9.58 4203 642927970 XP_972030.2 4255 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 255552749 XM_002517372.1 35 6.67583e-06 Ricinus communis mannosidase alpha class 2a, putative, mRNA K01231 MAN2 alpha-mannosidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01231 Q24451 2373 7.7e-266 Alpha-mannosidase 2 OS=Drosophila melanogaster GN=alpha-Man-II PE=1 SV=2 PF09261//PF07748//PF08053//PF01074 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 C-terminal domain//Tryptophanase operon leader peptide//Glycosyl hydrolases family 38 N-terminal domain GO:0031554//GO:0031556//GO:0005975//GO:0006013 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome//carbohydrate metabolic process//mannose metabolic process GO:0004553//GO:0015923//GO:0004559//GO:0008270 hydrolase activity, hydrolyzing O-glycosyl compounds//mannosidase activity//alpha-mannosidase activity//zinc ion binding -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.43993 BP_3 21.04 1.11 1205 607357065 EZA51539.1 229 2.2e-16 hypothetical protein X777_09786 [Cerapachys biroi] 462299627 APGK01051253.1 52 6.649e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43996 BP_3 3.40 0.32 800 -- -- -- -- -- 462299627 APGK01051253.1 52 4.35447e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43997 BP_3 9.71 0.58 1092 -- -- -- -- -- 462299627 APGK01051253.1 52 6.0144e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44002 BP_3 2.63 0.61 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44003 BP_3 143.73 3.35 2359 -- -- -- -- -- 642912782 XM_008203028.1 89 3.5696e-36 PREDICTED: Tribolium castaneum held out wings (how), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44004 BP_3 424.61 12.48 1932 642923427 XP_008193740.1 1289 4.3e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6JFQ6 386 9.0e-36 Clavesin-1 OS=Rattus norvegicus GN=Clvs1 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.44006 BP_3 279.76 1.51 9213 270002460 EEZ98907.1 3799 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1803 2.1e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF02148//PF07649//PF01363 Zn-finger in ubiquitin-hydrolases and other protein//C1-like domain//FYVE zinc finger GO:0055114 oxidation-reduction process GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.44007 BP_3 171.31 0.92 9269 270002460 EEZ98907.1 5010 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1802 2.8e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF02148//PF07649//PF01363 Zn-finger in ubiquitin-hydrolases and other protein//C1-like domain//FYVE zinc finger GO:0055114 oxidation-reduction process GO:0046872//GO:0047134//GO:0008270 metal ion binding//protein-disulfide reductase activity//zinc ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.44008 BP_3 198.96 2.00 5093 642912265 XP_008200629.1 1187 7.6e-127 PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912267|ref|XP_008200630.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912269|ref|XP_008200631.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q6IRB8 281 3.5e-23 Lysine-specific demethylase 3A-A OS=Xenopus laevis GN=kdm3a-a PE=2 SV=1 PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-8309.44009 BP_3 221.35 2.79 4112 478251563 ENN72025.1 1955 5.4e-216 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1Z8J0 1065 3.5e-114 CWF19-like protein 1 homolog OS=Drosophila melanogaster GN=CG7741 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.4401 BP_3 23.00 0.43 2860 642932616 XP_008196921.1 983 1.9e-103 PREDICTED: forkhead box protein N2-like [Tribolium castaneum]>gi|270011538|gb|EFA07986.1| hypothetical protein TcasGA2_TC005573 [Tribolium castaneum] 817069969 XM_012401563.1 57 2.66572e-18 PREDICTED: Athalia rosae forkhead box protein J1-B-like (LOC105686600), mRNA K09402 FOXJ1 forkhead box protein J1 http://www.genome.jp/dbget-bin/www_bget?ko:K09402 F1R8Z9 346 5.8e-31 Forkhead box protein J1-B OS=Danio rerio GN=foxj1b PE=2 SV=1 PF00250//PF01080 Forkhead domain//Presenilin GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0004190 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//aspartic-type endopeptidase activity GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-8309.44010 BP_3 243.18 2.22 5571 91078406 XP_974522.1 2008 5.2e-222 PREDICTED: cirhin [Tribolium castaneum]>gi|270003991|gb|EFA00439.1| hypothetical protein TcasGA2_TC003293 [Tribolium castaneum] -- -- -- -- -- K14548 UTP4, CIRH1A U3 small nucleolar RNA-associated protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14548 Q969X6 742 1.4e-76 Cirhin OS=Homo sapiens GN=CIRH1A PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2048 WD40 repeat protein Cluster-8309.44011 BP_3 193.55 1.52 6435 642924086 XP_008194000.1 2791 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X2 [Tribolium castaneum] 194751946 XM_001958249.1 59 4.66727e-19 Drosophila ananassae GF23597 (Dana\GF23597), mRNA K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q9VW47 1468 1.0e-160 Mediator of RNA polymerase II transcription subunit 12 OS=Drosophila melanogaster GN=kto PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3598 Thyroid hormone receptor-associated protein complex, subunit TRAP230 Cluster-8309.44012 BP_3 1105.44 5.97 9210 642913168 XP_008201419.1 1661 1.5e-181 PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum]>gi|642913170|ref|XP_008201420.1| PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum] 642913399 XM_008202772.1 149 6.23456e-69 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X3, mRNA K10358 MYO6 myosin VI http://www.genome.jp/dbget-bin/www_bget?ko:K10358 Q01989 1300 4.4e-141 Myosin heavy chain 95F OS=Drosophila melanogaster GN=jar PE=2 SV=4 PF13465//PF01363//PF13912//PF02724//PF02892//PF02487//PF06459//PF00096//PF01943//PF00063//PF00612 Zinc-finger double domain//FYVE zinc finger//C2H2-type zinc finger//CDC45-like protein//BED zinc finger//CLN3 protein//Ryanodine Receptor TM 4-6//Zinc finger, C2H2 type//Polysaccharide biosynthesis protein//Myosin head (motor domain)//IQ calmodulin-binding motif GO:0000271//GO:0006816//GO:0006270//GO:0006874 polysaccharide biosynthetic process//calcium ion transport//DNA replication initiation//cellular calcium ion homeostasis GO:0005524//GO:0003677//GO:0005219//GO:0005515//GO:0003774//GO:0046872 ATP binding//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding//motor activity//metal ion binding GO:0016021//GO:0016459//GO:0005622//GO:0016020 integral component of membrane//myosin complex//intracellular//membrane KOG0163 Myosin class VI heavy chain Cluster-8309.44014 BP_3 418.12 2.58 8097 642926340 XP_008194885.1 3619 0.0e+00 PREDICTED: small G protein signaling modulator 1 isoform X1 [Tribolium castaneum]>gi|270009053|gb|EFA05501.1| hypothetical protein TcasGA2_TC015686 [Tribolium castaneum] 195482092 XM_002101873.1 376 0 Drosophila yakuba GE17884 (Dyak\GE17884), partial mRNA -- -- -- -- Q8BPQ7 2332 8.4e-261 Small G protein signaling modulator 1 OS=Mus musculus GN=Sgsm1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1648 Uncharacterized conserved protein, contains RUN, BRK and TBC domains Cluster-8309.44019 BP_3 28.00 5.91 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4402 BP_3 2.00 0.31 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44022 BP_3 17.60 3.62 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44023 BP_3 2267.36 33.73 3532 546673138 ERL84803.1 2449 2.4e-273 hypothetical protein D910_02228 [Dendroctonus ponderosae] 645036531 XM_001607427.3 100 4.12052e-42 PREDICTED: Nasonia vitripennis ribulose-phosphate 3-epimerase (LOC100121800), mRNA K01937 pyrG, CTPS CTP synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01937 Q2M197 1861 1.5e-206 CTP synthase OS=Drosophila pseudoobscura pseudoobscura GN=CTPsyn PE=3 SV=2 PF16941//PF00215//PF07722//PF06418//PF01729//PF00834 Putative cyclodextrin porin//Orotidine 5'-phosphate decarboxylase / HUMPS family//Peptidase C26//CTP synthase N-terminus//Quinolinate phosphoribosyl transferase, C-terminal domain//Ribulose-phosphate 3 epimerase family GO:0005975//GO:0006541//GO:0009435//GO:0006206//GO:0046497//GO:0006221//GO:0098657//GO:0006207 carbohydrate metabolic process//glutamine metabolic process//NAD biosynthetic process//pyrimidine nucleobase metabolic process//nicotinate nucleotide metabolic process//pyrimidine nucleotide biosynthetic process//import into cell//'de novo' pyrimidine nucleobase biosynthetic process GO:0004514//GO:0004590//GO:0003883//GO:0016787//GO:0016857 nicotinate-nucleotide diphosphorylase (carboxylating) activity//orotidine-5'-phosphate decarboxylase activity//CTP synthase activity//hydrolase activity//racemase and epimerase activity, acting on carbohydrates and derivatives -- -- KOG2387 CTP synthase (UTP-ammonia lyase) Cluster-8309.44025 BP_3 1544.98 24.70 3306 642917516 XP_969396.3 1985 1.4e-219 PREDICTED: fragile X mental retardation syndrome-related protein 1 isoform X2 [Tribolium castaneum] 642917515 XM_964303.3 446 0 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X2, mRNA K15516 FMR fragile X mental retardation protein http://www.genome.jp/dbget-bin/www_bget?ko:K15516 Q9NFU0 1214 1.5e-131 Fragile X mental retardation syndrome-related protein 1 OS=Drosophila melanogaster GN=Fmr1 PE=1 SV=1 PF13184//PF13014//PF00013//PF12235//PF07650//PF06331 NusA-like KH domain//KH domain//KH domain//Fragile X-related 1 protein core C terminal//KH domain//Transcription factor TFIIH complex subunit Tfb5 GO:0006355//GO:0006289 regulation of transcription, DNA-templated//nucleotide-excision repair GO:0003723 RNA binding GO:0000439 core TFIIH complex -- -- Cluster-8309.44026 BP_3 518.28 32.90 1051 642917518 XP_008191235.1 181 7.0e-11 PREDICTED: fragile X mental retardation syndrome-related protein 1 isoform X3 [Tribolium castaneum] 642917523 XM_008193017.1 66 9.53829e-24 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44029 BP_3 1000.34 11.92 4336 478257240 ENN77403.1 3447 0.0e+00 hypothetical protein YQE_06228, partial [Dendroctonus ponderosae] 768451728 XM_011569773.1 111 3.8903e-48 PREDICTED: Plutella xylostella GTPase-activating protein-like (LOC105397755), partial mRNA K12380 RASA3 Ras GTPase-activating protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12380 Q14644 1808 2.6e-200 Ras GTPase-activating protein 3 OS=Homo sapiens GN=RASA3 PE=1 SV=3 PF00779//PF00616//PF00168 BTK motif//GTPase-activator protein for Ras-like GTPase//C2 domain GO:0043087//GO:0035556 regulation of GTPase activity//intracellular signal transduction GO:0005515 protein binding -- -- KOG2059 Ras GTPase-activating protein Cluster-8309.44030 BP_3 246.51 4.17 3138 642939832 XP_008190719.1 942 1.2e-98 PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum]>gi|642939834|ref|XP_008190783.1| PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CCG1 288 3.4e-24 Zinc finger C2HC domain-containing protein 1C OS=Mus musculus GN=Zc2hc1c PE=2 SV=1 PF13465//PF00096//PF02313//PF01155//PF05191//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//Fumarate reductase subunit D//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0006144//GO:0046034//GO:0006464//GO:0006106 purine nucleobase metabolic process//ATP metabolic process//cellular protein modification process//fumarate metabolic process GO:0016151//GO:0004017//GO:0046872 nickel cation binding//adenylate kinase activity//metal ion binding GO:0016020 membrane KOG3940 Uncharacterized conserved protein Cluster-8309.44031 BP_3 1035.49 21.93 2568 642926791 XP_008195017.1 410 4.8e-37 PREDICTED: uncharacterized protein LOC103313467 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44033 BP_3 84.44 1.27 3507 642915289 XP_975869.2 2037 1.4e-225 PREDICTED: RING finger and SPRY domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R881 1386 1.8e-151 RING finger and SPRY domain-containing protein 1 OS=Pongo abelii GN=RSPRY1 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.44034 BP_3 62.39 0.90 3642 642915289 XP_975869.2 1723 3.8e-189 PREDICTED: RING finger and SPRY domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R881 1177 3.2e-127 RING finger and SPRY domain-containing protein 1 OS=Pongo abelii GN=RSPRY1 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.44038 BP_3 1570.00 102.78 1028 649572227 NP_001280512.1 1435 2.7e-156 clathrin heavy chain [Tribolium castaneum]>gi|270008499|gb|EFA04947.1| hypothetical protein TcasGA2_TC015014 [Tribolium castaneum]>gi|629511285|gb|AHY84716.1| clathrin heavy chain [Tribolium castaneum] 649572226 NM_001293583.1 402 0 Tribolium castaneum clathrin heavy chain (LOC656193), mRNA >gnl|BL_ORD_ID|19160611 Tribolium castaneum strain Georgia-1 clathrin heavy chain (Chc) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P49951 1195 7.4e-130 Clathrin heavy chain 1 OS=Bos taurus GN=CLTC PE=1 SV=1 -- -- GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198 structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.44042 BP_3 4396.40 55.29 4124 642919579 XP_008191929.1 3085 0.0e+00 PREDICTED: heat shock 70 kDa protein 4 isoform X2 [Tribolium castaneum]>gi|270005857|gb|EFA02305.1| hypothetical protein TcasGA2_TC007971 [Tribolium castaneum] -- -- -- -- -- K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q61316 1858 3.9e-206 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 PF02862//PF04355//PF06723 DDHD domain//SmpA / OmlA family//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0005524//GO:0046872 ATP binding//metal ion binding GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.44043 BP_3 6.54 28.13 268 270015668 EFA12116.1 188 2.8e-12 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.44044 BP_3 43.00 1.90 1380 91086175 XP_970802.1 1231 1.6e-132 PREDICTED: L-asparaginase isoform X1 [Tribolium castaneum]>gi|270009879|gb|EFA06327.1| hypothetical protein TcasGA2_TC009198 [Tribolium castaneum] -- -- -- -- -- K13278 ASPG 60kDa lysophospholipase http://www.genome.jp/dbget-bin/www_bget?ko:K13278 Q9U518 818 5.2e-86 L-asparaginase OS=Dirofilaria immitis PE=1 SV=1 PF00710 Asparaginase GO:0006522//GO:0006528//GO:0006520//GO:0006531 alanine metabolic process//asparagine metabolic process//cellular amino acid metabolic process//aspartate metabolic process GO:0004067 asparaginase activity -- -- KOG0503 Asparaginase Cluster-8309.44047 BP_3 121.24 1.24 4996 642913326 XP_008195269.1 1969 1.6e-217 PREDICTED: protein roadkill isoform X3 [Tribolium castaneum] 817216130 XM_012428712.1 388 0 PREDICTED: Orussus abietinus protein roadkill (LOC105701723), transcript variant X5, mRNA K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 1774 2.6e-196 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 PF05355//PF00917//PF00651 Apolipoprotein C-II//MATH domain//BTB/POZ domain GO:0006869//GO:0006629 lipid transport//lipid metabolic process GO:0005515//GO:0008047 protein binding//enzyme activator activity GO:0042627 chylomicron KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.44048 BP_3 266.99 2.84 4821 642913326 XP_008195269.1 1984 2.7e-219 PREDICTED: protein roadkill isoform X3 [Tribolium castaneum] 817216130 XM_012428712.1 388 0 PREDICTED: Orussus abietinus protein roadkill (LOC105701723), transcript variant X5, mRNA K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 1774 2.5e-196 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 PF00651//PF00917//PF05355 BTB/POZ domain//MATH domain//Apolipoprotein C-II GO:0006629//GO:0006869 lipid metabolic process//lipid transport GO:0005515//GO:0008047 protein binding//enzyme activator activity GO:0042627 chylomicron KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.44051 BP_3 188.73 2.03 4770 270001755 EEZ98202.1 1966 3.3e-217 hypothetical protein TcasGA2_TC000632 [Tribolium castaneum] 817216130 XM_012428712.1 388 0 PREDICTED: Orussus abietinus protein roadkill (LOC105701723), transcript variant X5, mRNA K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 1770 7.3e-196 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 PF00651//PF00917//PF05355 BTB/POZ domain//MATH domain//Apolipoprotein C-II GO:0006869//GO:0006629 lipid transport//lipid metabolic process GO:0008047//GO:0005515 enzyme activator activity//protein binding GO:0042627 chylomicron KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.44052 BP_3 5.74 0.31 1171 642926638 XP_008194951.1 621 7.4e-62 PREDICTED: LOW QUALITY PROTEIN: DNA-binding protein Ets97D [Tribolium castaneum] -- -- -- -- -- K09441 GABPA GA-binding protein transcription factor, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K09441 Q04688 393 8.4e-37 DNA-binding protein Ets97D OS=Drosophila melanogaster GN=Ets97D PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.44054 BP_3 50.00 1.73 1685 642925814 XP_970128.3 720 3.6e-73 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 524 7.8e-52 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0016491//GO:0050662//GO:0003824 oxidoreductase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.44055 BP_3 148.62 3.62 2269 270008593 EFA05041.1 2628 2.7e-294 hypothetical protein TcasGA2_TC015132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96AY4 1597 4.0e-176 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 PF07721//PF13181//PF10579//PF13414//PF13176//PF13374//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0007268 synaptic transmission GO:0042802//GO:0033130//GO:0043495//GO:0005515 identical protein binding//acetylcholine receptor binding//protein anchor//protein binding -- -- KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain Cluster-8309.44056 BP_3 2.00 6.24 279 270008593 EFA05041.1 420 3.6e-39 hypothetical protein TcasGA2_TC015132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96AY4 275 9.7e-24 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44058 BP_3 216.82 1.85 5927 642925926 XP_008194700.1 6390 0.0e+00 PREDICTED: tetratricopeptide repeat protein 28 [Tribolium castaneum] 347968281 XM_312278.5 861 0 Anopheles gambiae str. PEST AGAP002648-PA (AgaP_AGAP002648) mRNA, complete cds -- -- -- -- Q96AY4 3087 0.0e+00 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 PF10579//PF07721//PF13181//PF10255//PF13371//PF13374//PF00515//PF13176//PF07544//PF13414 Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Tetratricopeptide repeat//RNA polymerase I-associated factor PAF67//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//RNA polymerase II transcription mediator complex subunit 9//TPR repeat GO:0006357//GO:0006446//GO:0007268 regulation of transcription from RNA polymerase II promoter//regulation of translational initiation//synaptic transmission GO:0043495//GO:0003743//GO:0001104//GO:0033130//GO:0042802//GO:0005515 protein anchor//translation initiation factor activity//RNA polymerase II transcription cofactor activity//acetylcholine receptor binding//identical protein binding//protein binding GO:0005840//GO:0005737//GO:0005852//GO:0016592 ribosome//cytoplasm//eukaryotic translation initiation factor 3 complex//mediator complex KOG0548 Molecular co-chaperone STI1 Cluster-8309.44059 BP_3 4.00 1.62 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4406 BP_3 3.00 0.48 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44060 BP_3 1022.68 16.66 3250 546683908 ERL93656.1 2922 0.0e+00 hypothetical protein D910_10944 [Dendroctonus ponderosae] 195130912 XM_002009859.1 179 4.598e-86 Drosophila mojavensis GI14989 (Dmoj\GI14989), mRNA -- -- -- -- Q80XJ3 846 6.9e-89 Tetratricopeptide repeat protein 28 OS=Mus musculus GN=Ttc28 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44068 BP_3 34.06 0.56 3234 642913398 XP_008200993.1 1367 6.5e-148 PREDICTED: fruitless isoform X3 [Tribolium castaneum] 642913407 XM_008202776.1 210 2.67668e-103 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X7, mRNA -- -- -- -- Q8IN81 552 8.5e-55 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00651//PF00096 BTB/POZ domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.44069 BP_3 769.25 9.47 4206 642933107 XP_008197261.1 1670 6.2e-183 PREDICTED: prominin-like protein isoform X1 [Tribolium castaneum]>gi|270011437|gb|EFA07885.1| hypothetical protein TcasGA2_TC005459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 530 3.9e-52 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF04513//PF13903//PF07464//PF02417//PF07926//PF05356//PF05478//PF01442 Baculovirus polyhedron envelope protein, PEP, C terminus//PMP-22/EMP/MP20/Claudin tight junction//Apolipophorin-III precursor (apoLp-III)//Chromate transporter//TPR/MLP1/MLP2-like protein//Phage Coat protein B//Prominin//Apolipoprotein A1/A4/E domain GO:0006606//GO:0042157//GO:0015703//GO:0006869 protein import into nucleus//lipoprotein metabolic process//chromate transport//lipid transport GO:0015109//GO:0008289//GO:0005198 chromate transmembrane transporter activity//lipid binding//structural molecule activity GO:0005576//GO:0016021//GO:0019028//GO:0019031 extracellular region//integral component of membrane//viral capsid//viral envelope KOG4331 Polytopic membrane protein Prominin Cluster-8309.44071 BP_3 36.22 0.97 2089 642915964 XP_008190829.1 1006 3.0e-106 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 316 1.3e-27 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44072 BP_3 93.98 3.81 1481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.44073 BP_3 67.65 1.48 2490 795011494 XP_011872774.1 366 5.9e-32 PREDICTED: uncharacterized protein LOC105564750, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.44075 BP_3 176.52 9.38 1199 91093479 XP_968090.1 424 5.3e-39 PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930712|ref|XP_008199997.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930714|ref|XP_008199998.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930716|ref|XP_008199999.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930718|ref|XP_008200000.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|270012666|gb|EFA09114.1| hypothetical protein TcasGA2_TC015974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.44076 BP_3 662.71 7.59 4501 91087363 XP_975631.1 632 1.5e-62 PREDICTED: iron-sulfur cluster assembly enzyme ISCU, mitochondrial [Tribolium castaneum]>gi|270010618|gb|EFA07066.1| hypothetical protein TcasGA2_TC010045 [Tribolium castaneum] 844835377 XM_012936598.1 119 1.44265e-52 Schistosoma haematobium Iron-sulfur cluster assembly enzyme ISCU, mitochondrial mRNA K04488 iscU, nifU nitrogen fixation protein NifU and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K04488 Q9D7P6 568 1.6e-56 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial OS=Mus musculus GN=Iscu PE=1 SV=1 PF09494//PF01592//PF05735 Slx4 endonuclease//NifU-like N terminal domain//Thrombospondin C-terminal region GO:0016226//GO:0006281//GO:0006260//GO:0007155//GO:0006308 iron-sulfur cluster assembly//DNA repair//DNA replication//cell adhesion//DNA catabolic process GO:0017108//GO:0051536//GO:0005509//GO:0005506 5'-flap endonuclease activity//iron-sulfur cluster binding//calcium ion binding//iron ion binding GO:0005634//GO:0005576//GO:0033557 nucleus//extracellular region//Slx1-Slx4 complex KOG3361 Iron binding protein involved in Fe-S cluster formation Cluster-8309.44077 BP_3 18.35 0.85 1328 91093479 XP_968090.1 424 5.9e-39 PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930712|ref|XP_008199997.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930714|ref|XP_008199998.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930716|ref|XP_008199999.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930718|ref|XP_008200000.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|270012666|gb|EFA09114.1| hypothetical protein TcasGA2_TC015974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.4408 BP_3 170.00 2.56 3497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44080 BP_3 1059.00 14.68 3768 642914430 XP_008201676.1 2675 1.6e-299 PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum]>gi|642914432|ref|XP_008201677.1| PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum] 642914431 XM_008203455.1 637 0 PREDICTED: Tribolium castaneum semaphorin-2A (LOC656741), transcript variant X3, mRNA -- -- -- -- Q9XZC8 2207 1.2e-246 Semaphorin-2A OS=Schistocerca gregaria GN=SEMA-2A PE=2 SV=1 PF01403//PF01437 Sema domain//Plexin repeat -- -- GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.44083 BP_3 331.00 4.14 4146 282721016 NP_001164208.1 2480 7.2e-277 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 6.3e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF15324//PF00400//PF12125//PF00646//PF12937//PF01557 Hedgehog signalling target//WD domain, G-beta repeat//D domain of beta-TrCP//F-box domain//F-box-like//Fumarylacetoacetate (FAA) hydrolase family GO:0008152//GO:0007224 metabolic process//smoothened signaling pathway GO:0046983//GO:0005515//GO:0003824 protein dimerization activity//protein binding//catalytic activity -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.44084 BP_3 219.90 1.74 6382 282721016 NP_001164208.1 2467 3.6e-275 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 397 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2110 3.7e-235 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF15324//PF00400//PF12125//PF00646//PF12937//PF01557 Hedgehog signalling target//WD domain, G-beta repeat//D domain of beta-TrCP//F-box domain//F-box-like//Fumarylacetoacetate (FAA) hydrolase family GO:0007224//GO:0008152 smoothened signaling pathway//metabolic process GO:0046983//GO:0005515//GO:0003824 protein dimerization activity//protein binding//catalytic activity -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.44085 BP_3 248.00 6.09 2253 642920207 XP_008192249.1 940 1.5e-98 PREDICTED: plancitoxin-1 [Tribolium castaneum] -- -- -- -- -- K01158 DNASE2 deoxyribonuclease II http://www.genome.jp/dbget-bin/www_bget?ko:K01158 Q75WF2 570 4.8e-57 Plancitoxin-1 OS=Acanthaster planci PE=1 SV=1 PF03265//PF15880 Deoxyribonuclease II//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial GO:0006259//GO:0006308 DNA metabolic process//DNA catabolic process GO:0004531 deoxyribonuclease II activity GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG3825 Deoxyribonuclease II Cluster-8309.44092 BP_3 1223.43 18.28 3517 642928441 XP_008193786.1 274 3.9e-21 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44093 BP_3 2732.76 35.48 4004 189240839 XP_001812334.1 3167 0.0e+00 PREDICTED: SWI/SNF complex subunit SMARCC2 [Tribolium castaneum]>gi|270013718|gb|EFA10166.1| hypothetical protein TcasGA2_TC012356 [Tribolium castaneum] 585702584 XM_006897683.1 41 2.93678e-09 PREDICTED: Elephantulus edwardii SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), mRNA K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q8TAQ2 1969 5.1e-219 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens GN=SMARCC2 PE=1 SV=1 PF04433//PF09268 SWIRM domain//Clathrin, heavy-chain linker GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005488//GO:0005515//GO:0005198 binding//protein binding//structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle KOG1279 Chromatin remodeling factor subunit and related transcription factors Cluster-8309.44094 BP_3 54.54 0.67 4215 642939478 XP_008197026.1 1937 6.8e-214 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 724 1.3e-74 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF00854//PF06432//PF04923//PF07690 POT family//Phosphatidylinositol N-acetylglucosaminyltransferase//Ninjurin//Major Facilitator Superfamily GO:0007155//GO:0006506//GO:0042246//GO:0006810//GO:0055085 cell adhesion//GPI anchor biosynthetic process//tissue regeneration//transport//transmembrane transport GO:0005215//GO:0017176 transporter activity//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.44095 BP_3 134.45 1.96 3590 642924494 XP_008194318.1 1947 4.0e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 9.0e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.44097 BP_3 349.03 4.32 4184 642913457 XP_008201020.1 3978 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.2e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00023//PF00784//PF13606 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.44098 BP_3 106.68 1.34 4115 642913457 XP_008201020.1 4091 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.1e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00023//PF00784 Ankyrin repeat//Ankyrin repeat//MyTH4 domain -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.44103 BP_3 254.17 5.06 2712 642920316 XP_008192296.1 1643 5.4e-180 PREDICTED: histone-lysine N-methyltransferase setd3 [Tribolium castaneum] -- -- -- -- -- K19199 SETD3 histone-lysine N-methyltransferase SETD3 http://www.genome.jp/dbget-bin/www_bget?ko:K19199 Q5ZML9 864 4.7e-91 Histone-lysine N-methyltransferase setd3 OS=Gallus gallus GN=SETD3 PE=2 SV=1 PF00856//PF00253 SET domain//Ribosomal protein S14p/S29e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1337 N-methyltransferase Cluster-8309.44106 BP_3 4304.71 13.65 15492 189237595 XP_966729.2 2234 9.0e-248 PREDICTED: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [Tribolium castaneum] 642910996 XM_968304.3 331 7.04623e-170 PREDICTED: Tribolium castaneum single-stranded DNA-binding protein 3 (LOC662190), transcript variant X3, mRNA K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 P49071 1432 3.7e-156 MAP kinase-activated protein kinase 2 OS=Drosophila melanogaster GN=MAPk-Ak2 PE=2 SV=1 PF00069//PF09029//PF07714//PF01212//PF01053//PF08001//PF06016//PF00155//PF06293 Protein kinase domain//5-aminolevulinate synthase presequence//Protein tyrosine kinase//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme//CMV US//Reovirus core-spike protein lambda-2 (L2)//Aminotransferase class I and II//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0042967//GO:0006468//GO:0006563//GO:0009058//GO:0006778//GO:0006566//GO:0006520//GO:0006783//GO:0006544//GO:0030683//GO:0009451//GO:0006370 acyl-carrier-protein biosynthetic process//protein phosphorylation//L-serine metabolic process//biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process//cellular amino acid metabolic process//heme biosynthetic process//glycine metabolic process//evasion or tolerance by virus of host immune response//RNA modification//7-methylguanosine mRNA capping GO:0005524//GO:0016829//GO:0003870//GO:0004484//GO:0030170//GO:0004482//GO:0004672//GO:0016773 ATP binding//lyase activity//5-aminolevulinate synthase activity//mRNA guanylyltransferase activity//pyridoxal phosphate binding//mRNA (guanine-N7-)-methyltransferase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0019028//GO:0044386//GO:0005759//GO:0016020 viral capsid//integral to host endoplasmic reticulum membrane//mitochondrial matrix//membrane KOG0604 MAP kinase-activated protein kinase 2 Cluster-8309.44107 BP_3 326.05 33.70 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44108 BP_3 48.70 0.80 3213 -- -- -- -- -- 462302786 APGK01050086.1 56 1.07861e-17 Dendroctonus ponderosae Seq01050096, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44109 BP_3 10.00 2.01 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44110 BP_3 11.00 1.50 645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44111 BP_3 13.69 0.58 1423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44112 BP_3 29.27 0.70 2307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00681 Plectin repeat -- -- -- -- GO:0005856 cytoskeleton -- -- Cluster-8309.44114 BP_3 161.69 1.21 6712 642929667 XP_008195928.1 3270 0.0e+00 PREDICTED: probable Rho GTPase-activating protein CG5521 isoform X1 [Tribolium castaneum] 642929668 XM_970393.2 238 1.52026e-118 PREDICTED: Tribolium castaneum probable Rho GTPase-activating protein CG5521 (LOC664386), transcript variant X2, mRNA -- -- -- -- Q9VB98 1597 1.2e-175 Probable Rho GTPase-activating protein CG5521 OS=Drosophila melanogaster GN=CG5521 PE=1 SV=2 PF03367//PF02145//PF00130//PF01155//PF04135//PF03110 ZPR1 zinc-finger domain//Rap/ran-GAP//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Nucleolar RNA-binding protein, Nop10p family//SBP domain GO:0035556//GO:0001522//GO:0042254//GO:0051056//GO:0006464 intracellular signal transduction//pseudouridine synthesis//ribosome biogenesis//regulation of small GTPase mediated signal transduction//cellular protein modification process GO:0008270//GO:0016151//GO:0030515//GO:0003677//GO:0005096 zinc ion binding//nickel cation binding//snoRNA binding//DNA binding//GTPase activator activity GO:0005634//GO:0072588 nucleus//box H/ACA RNP complex KOG2703 C4-type Zn-finger protein Cluster-8309.44117 BP_3 524.13 12.93 2245 642928504 XP_008193818.1 868 3.3e-90 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2K6 283 9.2e-24 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.44119 BP_3 24.47 1.26 1231 478253914 ENN74206.1 988 2.2e-104 hypothetical protein YQE_09179, partial [Dendroctonus ponderosae]>gi|546674879|gb|ERL86165.1| hypothetical protein D910_03578 [Dendroctonus ponderosae] 780631737 XM_011687331.1 63 5.21717e-22 PREDICTED: Wasmannia auropunctata nicotinate phosphoribosyltransferase (LOC105448642), transcript variant X2, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 803 2.5e-84 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2511 Nicotinic acid phosphoribosyltransferase Cluster-8309.44120 BP_3 186.78 2.69 3643 817051906 XP_012253468.1 1791 5.0e-197 PREDICTED: autophagy-related protein 16-1 isoform X2 [Athalia rosae] -- -- -- -- -- K17890 ATG16L autophagy-related protein 16, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K17890 Q676U5 920 2.0e-97 Autophagy-related protein 16-1 OS=Homo sapiens GN=ATG16L1 PE=1 SV=2 PF08702//PF05837//PF00105//PF00400 Fibrinogen alpha/beta chain family//Centromere protein H (CENP-H)//Zinc finger, C4 type (two domains)//WD domain, G-beta repeat GO:0051258//GO:0051382//GO:0007165//GO:0030168//GO:0006355 protein polymerization//kinetochore assembly//signal transduction//platelet activation//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0005102//GO:0008270//GO:0030674//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//receptor binding//zinc ion binding//protein binding, bridging//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005577//GO:0000776 transcription factor complex//nucleus//fibrinogen complex//kinetochore KOG0288 WD40 repeat protein TipD Cluster-8309.44122 BP_3 45.50 0.77 3156 642911928 XP_967929.2 2694 8.4e-302 PREDICTED: uncharacterized protein LOC656296 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60611 151 2.6e-08 DNA-binding protein SATB1 OS=Mus musculus GN=Satb1 PE=1 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG3755 SATB1 matrix attachment region binding protein Cluster-8309.44124 BP_3 88.33 16.61 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44125 BP_3 146.98 1.58 4786 642925187 XP_008194461.1 3226 0.0e+00 PREDICTED: myelin regulatory factor isoform X2 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.36945e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1228 5.2e-133 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF05224//PF10152 NDT80 / PhoG like DNA-binding family//Predicted coiled-coil domain-containing protein (DUF2360) -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.44126 BP_3 258.93 1.56 8284 546680590 ERL90833.1 6072 0.0e+00 hypothetical protein D910_08178 [Dendroctonus ponderosae] 642925848 XM_008192328.1 61 4.65073e-20 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- Q6DFF9 2154 3.8e-240 Mitogen-activated protein kinase-binding protein 1 OS=Xenopus laevis GN=mapkbp1 PE=2 SV=1 PF00400//PF08367 WD domain, G-beta repeat//Peptidase M16C associated GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG1408 WD40 repeat protein Cluster-8309.44127 BP_3 226.93 3.84 3137 91090830 XP_971933.1 783 3.3e-80 PREDICTED: ras-related protein M-Ras [Tribolium castaneum]>gi|642935926|ref|XP_008198232.1| PREDICTED: ras-related protein M-Ras [Tribolium castaneum]>gi|270013249|gb|EFA09697.1| hypothetical protein TcasGA2_TC011829 [Tribolium castaneum] 332376259 BT128312.1 188 4.40506e-91 Dendroctonus ponderosae clone DPO105_N17 unknown mRNA K07831 MRAS Ras-related protein M-Ras http://www.genome.jp/dbget-bin/www_bget?ko:K07831 O08989 639 6.7e-65 Ras-related protein M-Ras OS=Mus musculus GN=Mras PE=1 SV=1 PF03193//PF08477//PF01926//PF00071//PF02421//PF04670//PF00025 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ras family//Ferrous iron transport protein B//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family GO:0015684//GO:0007264//GO:0006184 ferrous iron transport//small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0005525//GO:0003924//GO:0015093 GTP binding//GTPase activity//ferrous iron transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0395 Ras-related GTPase Cluster-8309.44129 BP_3 40.89 4.56 724 642929557 XP_008195884.1 854 4.4e-89 PREDICTED: focal adhesion kinase 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44132 BP_3 210.95 2.00 5364 270002048 EEZ98495.1 654 5.1e-65 hypothetical protein TcasGA2_TC000995 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44134 BP_3 1067.31 12.12 4535 642913586 XP_008201074.1 1578 3.1e-172 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] 768311758 CP010986.1 104 3.1689e-44 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- PF02166 Androgen receptor GO:0030521//GO:0007165//GO:0006355 androgen receptor signaling pathway//signal transduction//regulation of transcription, DNA-templated GO:0004882//GO:0005496//GO:0003677 androgen receptor activity//steroid binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.44135 BP_3 24.70 0.75 1882 642913592 XP_008201077.1 367 3.4e-32 PREDICTED: dentin sialophosphoprotein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.44136 BP_3 272.07 6.92 2186 642913592 XP_008201077.1 1546 7.6e-169 PREDICTED: dentin sialophosphoprotein isoform X2 [Tribolium castaneum] 768311758 CP010986.1 104 1.51555e-44 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- PF02166 Androgen receptor GO:0007165//GO:0030521//GO:0006355 signal transduction//androgen receptor signaling pathway//regulation of transcription, DNA-templated GO:0004882//GO:0003677//GO:0005496 androgen receptor activity//DNA binding//steroid binding GO:0005634 nucleus -- -- Cluster-8309.44138 BP_3 13.66 0.96 977 642913586 XP_008201074.1 369 1.0e-32 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] 768311758 CP010986.1 104 6.64626e-45 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- PF02166 Androgen receptor GO:0006355//GO:0007165//GO:0030521 regulation of transcription, DNA-templated//signal transduction//androgen receptor signaling pathway GO:0005496//GO:0003677//GO:0004882 steroid binding//DNA binding//androgen receptor activity GO:0005634 nucleus -- -- Cluster-8309.44140 BP_3 142.98 9.35 1029 642913586 XP_008201074.1 465 8.0e-44 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44142 BP_3 52.79 3.73 974 642913586 XP_008201074.1 465 7.6e-44 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44145 BP_3 4214.00 56.51 3886 91088515 XP_971706.1 1200 1.8e-128 PREDICTED: short-chain dehydrogenase/reductase family 16C member 6 [Tribolium castaneum] -- -- -- -- -- K15734 SDR16C5 all-trans-retinol dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K15734 A5PJJ7 506 2.2e-49 Short-chain dehydrogenase/reductase family 16C member 6 OS=Bos taurus GN=SDR16C6 PE=2 SV=1 PF02737//PF01209//PF01370//PF05175//PF13241//PF00899//PF03446//PF02882//PF01073//PF00106//PF02254//PF00208//PF03435//PF01210//PF02558//PF03721//PF02826//PF00056 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//ubiE/COQ5 methyltransferase family//NAD dependent epimerase/dehydratase family//Methyltransferase small domain//Putative NAD(P)-binding//ThiF family//NAD binding domain of 6-phosphogluconate dehydrogenase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//TrkA-N domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Ketopantoate reductase PanE/ApbA//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008210//GO:0046168//GO:0006633//GO:0006098//GO:0018874//GO:0008152//GO:0019354//GO:0006552//GO:0046487//GO:0006554//GO:0006779//GO:0055114//GO:0008207//GO:0006568//GO:0006813//GO:0006520//GO:0006631//GO:0009396//GO:0006550//GO:0006574//GO:0015940//GO:0008209//GO:0006694//GO:0019521 estrogen metabolic process//glycerol-3-phosphate catabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//metabolic process//siroheme biosynthetic process//leucine catabolic process//glyoxylate metabolic process//lysine catabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//tryptophan metabolic process//potassium ion transport//cellular amino acid metabolic process//fatty acid metabolic process//folic acid-containing compound biosynthetic process//isoleucine catabolic process//valine catabolic process//pantothenate biosynthetic process//androgen metabolic process//steroid biosynthetic process//D-gluconate metabolic process GO:0016491//GO:0043115//GO:0008677//GO:0004488//GO:0016616//GO:0003854//GO:0008168//GO:0051287//GO:0003824//GO:0008641//GO:0050662//GO:0003857//GO:0004616 oxidoreductase activity//precorrin-2 dehydrogenase activity//2-dehydropantoate 2-reductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//methyltransferase activity//NAD binding//catalytic activity//small protein activating enzyme activity//coenzyme binding//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 Cluster-8309.44146 BP_3 1177.83 31.89 2072 91090840 XP_972191.1 1205 2.5e-129 PREDICTED: N-acetyl-D-glucosamine kinase [Tribolium castaneum]>gi|270013990|gb|EFA10438.1| hypothetical protein TcasGA2_TC012681 [Tribolium castaneum] -- -- -- -- -- K00884 NAGK, nagK N-acetylglucosamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00884 Q9QZ08 717 4.0e-74 N-acetyl-D-glucosamine kinase OS=Mus musculus GN=Nagk PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1794 N-Acetylglucosamine kinase Cluster-8309.44148 BP_3 73.91 3.98 1187 645020575 XP_003426678.2 386 1.3e-34 PREDICTED: uncharacterized protein LOC100123516 isoform X1 [Nasonia vitripennis] 749773866 XM_011143969.1 77 8.29086e-30 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X1, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44149 BP_3 426.32 12.14 1985 645020577 XP_001608013.2 409 4.8e-37 PREDICTED: uncharacterized protein LOC100123516 isoform X2 [Nasonia vitripennis] 749773869 XM_011143970.1 77 1.4034e-29 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X2, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4415 BP_3 1.00 0.73 353 641647850 XP_008179855.1 179 4.0e-11 PREDICTED: piggyBac transposable element-derived protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44151 BP_3 2.00 0.34 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44153 BP_3 367.71 3.62 5181 91091502 XP_968873.1 1269 2.4e-136 PREDICTED: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270000935|gb|EEZ97382.1| hypothetical protein TcasGA2_TC011207 [Tribolium castaneum] -- -- -- -- -- K05605 HIBCH 3-hydroxyisobutyryl-CoA hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K05605 A2VDC2 912 2.4e-96 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Xenopus laevis GN=hibch PE=2 SV=1 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1684 Enoyl-CoA hydratase Cluster-8309.44156 BP_3 134.95 1.24 5540 91091502 XP_968873.1 1272 1.1e-136 PREDICTED: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270000935|gb|EEZ97382.1| hypothetical protein TcasGA2_TC011207 [Tribolium castaneum] -- -- -- -- -- K05605 HIBCH 3-hydroxyisobutyryl-CoA hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K05605 A2VDC2 912 2.6e-96 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Xenopus laevis GN=hibch PE=2 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0003824//GO:0016836 catalytic activity//hydro-lyase activity -- -- KOG1684 Enoyl-CoA hydratase Cluster-8309.44158 BP_3 76.85 1.29 3162 478253436 ENN73776.1 1496 6.9e-163 hypothetical protein YQE_09622, partial [Dendroctonus ponderosae] 676485074 XM_009065298.1 66 2.92999e-23 Lottia gigantea hypothetical protein partial mRNA K11141 ENPEP glutamyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11141 Q32LQ0 1079 6.5e-116 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433//PF08040 Peptidase family M1//MNLL subunit GO:0006118 obsolete electron transport GO:0003954//GO:0008237//GO:0008270 NADH dehydrogenase activity//metallopeptidase activity//zinc ion binding GO:0005739 mitochondrion -- -- Cluster-8309.44159 BP_3 60.55 4.63 922 270016206 EFA12652.1 326 9.5e-28 hypothetical protein TcasGA2_TC016253 [Tribolium castaneum] -- -- -- -- -- K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 Q9USX1 151 7.6e-09 Aminopeptidase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ape1 PE=3 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.44160 BP_3 291.64 3.64 4151 642935247 XP_008197929.1 4314 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 726 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1681 1.3e-185 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF00041//PF16656//PF05506 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Domain of unknown function (DUF756) GO:0016042//GO:0006771//GO:0019497//GO:0009395 lipid catabolic process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//phospholipid catabolic process GO:0004629//GO:0046872//GO:0003993//GO:0005515 phospholipase C activity//metal ion binding//acid phosphatase activity//protein binding -- -- -- -- Cluster-8309.44163 BP_3 84.61 1.71 2682 270007047 EFA03495.1 1081 7.8e-115 hypothetical protein TcasGA2_TC013495 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q9NPB8 481 1.2e-46 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Homo sapiens GN=GPCPD1 PE=1 SV=2 PF01868//PF03009 Domain of unknown function UPF0086//Glycerophosphoryl diester phosphodiesterase family GO:0008033//GO:0051252//GO:0006364//GO:0006629//GO:0006379 tRNA processing//regulation of RNA metabolic process//rRNA processing//lipid metabolic process//mRNA cleavage GO:0008081//GO:0004540//GO:0003723 phosphoric diester hydrolase activity//ribonuclease activity//RNA binding GO:0000172//GO:0030677 ribonuclease MRP complex//ribonuclease P complex KOG2421 Predicted starch-binding protein Cluster-8309.44164 BP_3 264.00 228.19 341 167234390 NP_001107818.1 253 1.0e-19 adipokinetic hormone 2 precursor [Tribolium castaneum]>gi|81170844|gb|ABB58740.1| AKH-II preprohormone [Tribolium castaneum]>gi|126116534|gb|ABN79649.1| adipokinetic hormone 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17128 168 3.0e-11 Hypertrehalosaemic prohormone OS=Blaberus discoidalis PE=1 SV=1 PF06377//PF00711 Adipokinetic hormone//Beta defensin GO:0006952//GO:0007165 defense response//signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.44165 BP_3 73.63 0.72 5223 642934019 XP_008197606.1 1061 3.2e-112 PREDICTED: PCTP-like protein isoform X1 [Tribolium castaneum] 642934018 XM_008199384.1 192 4.40331e-93 PREDICTED: Tribolium castaneum phosphatidylcholine transfer protein (LOC662808), transcript variant X1, mRNA -- -- -- -- Q9JMD3 495 5.6e-48 PCTP-like protein OS=Mus musculus GN=Stard10 PE=1 SV=1 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.44166 BP_3 874.97 11.11 4089 91076588 XP_968186.1 1366 1.1e-147 PREDICTED: transmembrane protein 194A [Tribolium castaneum]>gi|270002381|gb|EEZ98828.1| hypothetical protein TcasGA2_TC004435 [Tribolium castaneum] 642912650 XM_963240.2 181 4.48235e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K10391 TUBE tubulin epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K10391 Q9D6T1 783 1.8e-81 Tubulin epsilon chain OS=Mus musculus GN=Tube1 PE=2 SV=1 PF04632//PF04111//PF16326//PF05531//PF01920//PF04871//PF03357//PF00091//PF00462//PF07544 Fusaric acid resistance protein family//Autophagy protein Apg6//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Prefoldin subunit//Uso1 / p115 like vesicle tethering protein, C terminal region//Snf7//Tubulin/FtsZ family, GTPase domain//Glutaredoxin//RNA polymerase II transcription mediator complex subunit 9 GO:0006457//GO:0045454//GO:0006914//GO:0006810//GO:0006886//GO:0006357//GO:0006118//GO:0007034//GO:0015031 protein folding//cell redox homeostasis//autophagy//transport//intracellular protein transport//regulation of transcription from RNA polymerase II promoter//obsolete electron transport//vacuolar transport//protein transport GO:0003677//GO:0001104//GO:0009055//GO:0015035//GO:0003924//GO:0051082//GO:0008565 DNA binding//RNA polymerase II transcription cofactor activity//electron carrier activity//protein disulfide oxidoreductase activity//GTPase activity//unfolded protein binding//protein transporter activity GO:0016592//GO:0005886//GO:0016020//GO:0019028//GO:0016272//GO:0005737 mediator complex//plasma membrane//membrane//viral capsid//prefoldin complex//cytoplasm KOG3817 Uncharacterized conserved protein Cluster-8309.4417 BP_3 5.00 0.82 586 607354393 EZA49035.1 172 4.3e-10 Histone-lysine N-methyltransferase SETMAR [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44170 BP_3 1024.80 10.29 5090 91078490 XP_968588.1 2030 1.3e-224 PREDICTED: COP9 signalosome complex subunit 1 [Tribolium castaneum]>gi|270004016|gb|EFA00464.1| hypothetical protein TcasGA2_TC003322 [Tribolium castaneum] 642915516 XM_963495.3 360 0 PREDICTED: Tribolium castaneum COP9 signalosome complex subunit 1 (LOC657006), mRNA K12175 GPS1, COPS1, CSN1 COP9 signalosome complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12175 Q99LD4 1580 8.4e-174 COP9 signalosome complex subunit 1 OS=Mus musculus GN=Gps1 PE=1 SV=1 PF13414//PF01399//PF00515 TPR repeat//PCI domain//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0686 COP9 signalosome, subunit CSN1 Cluster-8309.44172 BP_3 3.54 0.41 711 270006594 EFA03042.1 295 2.9e-24 hypothetical protein TcasGA2_TC010468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44174 BP_3 67.00 0.77 4462 478265842 ENN82601.1 273 6.4e-21 hypothetical protein YQE_01027, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01442//PF02734 Apolipoprotein A1/A4/E domain//DAK2 domain GO:0006869//GO:0006071//GO:0046486//GO:0042157 lipid transport//glycerol metabolic process//glycerolipid metabolic process//lipoprotein metabolic process GO:0004371//GO:0008289 glycerone kinase activity//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.44179 BP_3 1100.59 5.95 9200 270002460 EEZ98907.1 4932 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1803 2.1e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF02148//PF07649//PF01363 Zn-finger in ubiquitin-hydrolases and other protein//C1-like domain//FYVE zinc finger GO:0055114 oxidation-reduction process GO:0008270//GO:0046872//GO:0047134 zinc ion binding//metal ion binding//protein-disulfide reductase activity -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.44183 BP_3 64.64 1.39 2537 546685044 ERL94598.1 1467 1.3e-159 hypothetical protein D910_11875 [Dendroctonus ponderosae] 126142258 EF387104.1 128 8.02953e-58 Drosophila simulans strain S132 Malic DH (Mdh) gene, partial sequence K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P06801 1037 3.8e-111 NADP-dependent malic enzyme OS=Mus musculus GN=Me1 PE=1 SV=2 PF03949//PF00390//PF01420 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain//Type I restriction modification DNA specificity domain GO:0006099//GO:0015976//GO:0006090//GO:0055114//GO:0006108//GO:0006304 tricarboxylic acid cycle//carbon utilization//pyruvate metabolic process//oxidation-reduction process//malate metabolic process//DNA modification GO:0004471//GO:0003677//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//DNA binding//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.44185 BP_3 1056.61 9.79 5492 642913045 XP_008201364.1 6843 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] 642913044 XM_008203142.1 708 0 PREDICTED: Tribolium castaneum fibrillin-2 (LOC663193), mRNA -- -- -- -- Q61555 3664 0.0e+00 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.44187 BP_3 142.17 1.67 4394 270010422 EFA06870.1 1347 1.8e-145 hypothetical protein TcasGA2_TC009815 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05891 AdoMet dependent proline di-methyltransferase GO:0006480 N-terminal protein amino acid methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.44188 BP_3 63.91 1.36 2552 637366323 XP_008121191.1 428 3.9e-39 PREDICTED: oocyte zinc finger protein XlCOF6-like, partial [Anolis carolinensis] 195570403 XM_002103161.1 88 1.39048e-35 Drosophila simulans GD19093 (Dsim\GD19093), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NQZ8 410 2.0e-38 Endothelial zinc finger protein induced by tumor necrosis factor alpha OS=Homo sapiens GN=ZNF71 PE=2 SV=1 PF00096//PF13465//PF13912//PF07776//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.44191 BP_3 102.75 0.63 8148 642916295 XP_008190964.1 6336 0.0e+00 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X2 [Tribolium castaneum] 642916294 XM_008192742.1 997 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 1 (LOC663739), transcript variant X2, mRNA K12604 CNOT1, NOT1 CCR4-NOT transcription complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12604 Q6ZQ08 3762 0.0e+00 CCR4-NOT transcription complex subunit 1 OS=Mus musculus GN=Cnot1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1831 Negative regulator of transcription Cluster-8309.44196 BP_3 41.00 2.53 1073 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11081//PF07809 Protein of unknown function (DUF2890)//RTP801 C-terminal region GO:0009968//GO:0016032 negative regulation of signal transduction//viral process -- -- GO:0005737 cytoplasm -- -- Cluster-8309.44198 BP_3 1440.86 33.19 2384 282165792 NP_001164135.1 870 2.0e-90 drongo protein isoform 2 [Tribolium castaneum]>gi|270008252|gb|EFA04700.1| drongo [Tribolium castaneum] -- -- -- -- -- K15044 AGFG1 Arf-GAP domain and FG repeats-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15044 P52594 415 4.8e-39 Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens GN=AGFG1 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0702 Predicted GTPase-activating protein Cluster-8309.442 BP_3 7.00 2.76 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4420 BP_3 7.20 0.41 1133 642913680 XP_008201115.1 765 1.4e-78 PREDICTED: protein amalgam-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44200 BP_3 125.59 7.92 1056 91079212 XP_966680.1 897 6.6e-94 PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|642916704|ref|XP_008192258.1| PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|270004989|gb|EFA01437.1| hypothetical protein TcasGA2_TC030667 [Tribolium castaneum] 665815702 XM_008558299.1 225 3.92634e-112 PREDICTED: Microplitis demolitor myosin regulatory light chain sqh (LOC103577593), mRNA K12755 MYL9 myosin regulatory light chain 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12755 P40423 847 1.7e-89 Myosin regulatory light chain sqh OS=Drosophila melanogaster GN=sqh PE=1 SV=1 PF10591//PF13833//PF00036//PF13405//PF13499//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.44201 BP_3 12.87 0.43 1721 91079212 XP_966680.1 587 9.6e-58 PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|642916704|ref|XP_008192258.1| PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|270004989|gb|EFA01437.1| hypothetical protein TcasGA2_TC030667 [Tribolium castaneum] 642916705 XM_961587.3 110 5.48789e-48 PREDICTED: Tribolium castaneum myosin regulatory light chain sqh (LOC658477), transcript variant X2, mRNA K12755 MYL9 myosin regulatory light chain 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12755 P40423 560 5.3e-56 Myosin regulatory light chain sqh OS=Drosophila melanogaster GN=sqh PE=1 SV=1 PF13499//PF13833//PF00036//PF13405 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.44204 BP_3 295.87 2.87 5254 642939784 XP_970158.2 1024 6.2e-108 PREDICTED: mesoderm induction early response protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T105 566 3.3e-56 Mesoderm induction early response protein 1 OS=Xenopus laevis GN=mier1 PE=2 SV=1 PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.44205 BP_3 631.05 10.02 3327 642919875 XP_008192105.1 3515 0.0e+00 PREDICTED: N-acetyltransferase 10 isoform X1 [Tribolium castaneum]>gi|270005385|gb|EFA01833.1| hypothetical protein TcasGA2_TC007435 [Tribolium castaneum] -- -- -- -- -- K14521 NAT10, KRE33 N-acetyltransferase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14521 Q8K224 2996 0.0e+00 N-acetyltransferase 10 OS=Mus musculus GN=Nat10 PE=2 SV=1 PF13718//PF13508//PF00583 GNAT acetyltransferase 2//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG2036 Predicted P-loop ATPase fused to an acetyltransferase Cluster-8309.44210 BP_3 49.81 1.27 2186 642923250 XP_008193676.1 212 3.7e-14 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q9VUX2 189 7.1e-13 E3 ubiquitin-protein ligase mind-bomb OS=Drosophila melanogaster GN=mib1 PE=1 SV=3 PF00097//PF14634//PF13639//PF15898 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Ring finger domain//cGMP-dependent protein kinase interacting domain -- -- GO:0046872//GO:0005515//GO:0019901//GO:0043169//GO:0008270 metal ion binding//protein binding//protein kinase binding//cation binding//zinc ion binding -- -- -- -- Cluster-8309.44212 BP_3 32.38 5.75 563 642930844 XP_008196110.1 150 1.5e-07 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44214 BP_3 109.89 0.74 7416 270006156 EFA02604.1 2074 1.5e-229 hypothetical protein TcasGA2_TC008323 [Tribolium castaneum] 820858958 XM_012490996.1 144 3.0184e-66 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7RTS6 149 1.0e-07 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 PF01769//PF01499 Divalent cation transporter//Herpesvirus UL25 family GO:0006812//GO:0019072 cation transport//viral genome packaging GO:0008324 cation transmembrane transporter activity GO:0042025 host cell nucleus KOG4740 Uncharacterized conserved protein Cluster-8309.44215 BP_3 18.99 0.61 1802 820858959 XP_012346450.1 487 4.0e-46 PREDICTED: uncharacterized protein LOC100869561 [Apis florea] 645008120 XM_003425686.2 127 2.03956e-57 PREDICTED: Nasonia vitripennis uncharacterized LOC100121483 (LOC100121483), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF03286//PF03348//PF05529//PF16965//PF00856//PF12326//PF13965//PF02862//PF07168//PF03896//PF06459//PF03522 Pox virus Ag35 surface protein//Serine incorporator (Serinc)//B-cell receptor-associated protein 31-like//Ceramide synthase regulator//SET domain//N-glycosylation protein//dsRNA-gated channel SID-1//DDHD domain//Ureide permease//Translocon-associated protein (TRAP), alpha subunit//Ryanodine Receptor TM 4-6//Solute carrier family 12 GO:0034599//GO:0006811//GO:0071705//GO:0006874//GO:0033227//GO:0015931//GO:0006816//GO:0006810//GO:0006886 cellular response to oxidative stress//ion transport//nitrogen compound transport//cellular calcium ion homeostasis//dsRNA transport//nucleobase-containing compound transport//calcium ion transport//transport//intracellular protein transport GO:0051033//GO:0046872//GO:0005215//GO:0005515//GO:0005219//GO:0030234 RNA transmembrane transporter activity//metal ion binding//transporter activity//protein binding//ryanodine-sensitive calcium-release channel activity//enzyme regulator activity GO:0016020//GO:0005789//GO:0030176//GO:0005783//GO:0019031//GO:0005622//GO:0016021 membrane//endoplasmic reticulum membrane//integral component of endoplasmic reticulum membrane//endoplasmic reticulum//viral envelope//intracellular//integral component of membrane -- -- Cluster-8309.44216 BP_3 45.79 1.59 1684 642921007 XP_008192651.1 1341 3.5e-145 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 6.74952e-67 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7M734 135 1.0e-06 Otopetrin-1 OS=Rattus norvegicus GN=Otop1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44217 BP_3 518.52 5.83 4575 91080859 XP_976120.1 630 2.6e-62 PREDICTED: lipid storage droplets surface-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270005933|gb|EFA02381.1| hypothetical protein TcasGA2_TC008057 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 205 2.1e-14 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44218 BP_3 436.35 3.76 5880 91087589 XP_971974.1 2420 9.3e-270 PREDICTED: RNA polymerase II subunit A C-terminal domain phosphatase [Tribolium castaneum]>gi|270010700|gb|EFA07148.1| hypothetical protein TcasGA2_TC010139 [Tribolium castaneum] -- -- -- -- -- K15732 CTDP1, FCP1 RNA polymerase II subunit A C-terminal domain phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K15732 Q7TSG2 708 1.3e-72 RNA polymerase II subunit A C-terminal domain phosphatase OS=Mus musculus GN=Ctdp1 PE=1 SV=1 PF02932//PF00366 Neurotransmitter-gated ion-channel transmembrane region//Ribosomal protein S17 GO:0042254//GO:0006811//GO:0006412 ribosome biogenesis//ion transport//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular KOG0323 TFIIF-interacting CTD phosphatases, including NLI-interacting factor Cluster-8309.44219 BP_3 92.70 3.68 1506 642913680 XP_008201115.1 852 1.6e-88 PREDICTED: protein amalgam-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01411//PF13895 tRNA synthetases class II (A)//Immunoglobulin domain GO:0006522//GO:0006419//GO:0006531 alanine metabolic process//alanyl-tRNA aminoacylation//aspartate metabolic process GO:0005524//GO:0000166//GO:0005515//GO:0004813 ATP binding//nucleotide binding//protein binding//alanine-tRNA ligase activity -- -- -- -- Cluster-8309.44220 BP_3 898.20 298.86 436 478255706 ENN75917.1 293 3.0e-24 hypothetical protein YQE_07558, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44222 BP_3 7.81 0.37 1323 91084535 XP_972884.1 1277 7.2e-138 PREDICTED: NADH-ubiquinone oxidoreductase 49 kDa subunit [Tribolium castaneum]>gi|270009249|gb|EFA05697.1| hypothetical protein TcasGA2_TC015217 [Tribolium castaneum] 751773600 XM_011215103.1 134 1.90958e-61 PREDICTED: Bactrocera dorsalis NADH-ubiquinone oxidoreductase 49 kDa subunit (LOC105233130), mRNA K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q641Y2 1023 8.4e-110 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Rattus norvegicus GN=Ndufs2 PE=1 SV=1 PF00346//PF00374//PF00165 Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Nickel-dependent hydrogenase//Bacterial regulatory helix-turn-helix proteins, AraC family GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0051287//GO:0016151//GO:0016651//GO:0003700//GO:0048038//GO:0043565 NAD binding//nickel cation binding//oxidoreductase activity, acting on NAD(P)H//transcription factor activity, sequence-specific DNA binding//quinone binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-8309.44224 BP_3 95.73 4.74 1265 91086881 XP_970132.1 1278 5.3e-138 PREDICTED: RING finger protein 113A [Tribolium castaneum]>gi|270010474|gb|EFA06922.1| hypothetical protein TcasGA2_TC009871 [Tribolium castaneum] 195450055 XM_002072309.1 74 4.11854e-28 Drosophila willistoni GK22373 (Dwil\GK22373), mRNA K13127 RNF113A, CWC24 RING finger protein 113A http://www.genome.jp/dbget-bin/www_bget?ko:K13127 O15541 956 4.7e-102 RING finger protein 113A OS=Homo sapiens GN=RNF113A PE=1 SV=1 PF00642//PF03854//PF16685//PF07297//PF13639//PF14634//PF00097//PF11789 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//P-11 zinc finger//zinc RING finger of MSL2//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Ring finger domain//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit GO:0009059 macromolecule biosynthetic process GO:0003723//GO:0061630//GO:0005515//GO:0008270//GO:0003676//GO:0046872 RNA binding//ubiquitin protein ligase activity//protein binding//zinc ion binding//nucleic acid binding//metal ion binding GO:0030176 integral component of endoplasmic reticulum membrane KOG1813 Predicted E3 ubiquitin ligase Cluster-8309.44226 BP_3 111.82 0.94 6046 642912875 XP_008201292.1 4806 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X9 [Tribolium castaneum]>gi|270001881|gb|EEZ98328.1| hypothetical protein TcasGA2_TC000782 [Tribolium castaneum] 642912874 XM_008203070.1 1390 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1836 2.1e-203 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00628//PF07649//PF00781//PF00076//PF00609//PF00130//PF00788 PHD-finger//C1-like domain//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain GO:0007165//GO:0009395//GO:0007205//GO:0035556//GO:0055114//GO:0046486 signal transduction//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//intracellular signal transduction//oxidation-reduction process//glycerolipid metabolic process GO:0005515//GO:0004143//GO:0047134//GO:0046872//GO:0000166//GO:0003676//GO:0016301 protein binding//diacylglycerol kinase activity//protein-disulfide reductase activity//metal ion binding//nucleotide binding//nucleic acid binding//kinase activity GO:0005622 intracellular KOG1169 Diacylglycerol kinase Cluster-8309.44232 BP_3 46.00 0.49 4844 546675277 ERL86513.1 2764 9.9e-310 hypothetical protein D910_03917 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PD19 1667 6.5e-184 UPF0668 protein C10orf76 homolog OS=Mus musculus PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG4654 Uncharacterized conserved protein Cluster-8309.44234 BP_3 541.07 3.37 8030 189236343 XP_975398.2 1765 1.1e-193 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X3 [Tribolium castaneum] 642919611 XM_008193717.1 100 9.41791e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.8e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF02257//PF01388//PF12031 RFX DNA-binding domain//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518) GO:0006338//GO:0006355 chromatin remodeling//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.44237 BP_3 1058.70 21.22 2697 642937018 XP_008198655.1 2482 2.7e-277 PREDICTED: neutral ceramidase-like [Tribolium castaneum] -- -- -- -- -- K12349 ASAH2 neutral ceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K12349 Q9VA70 1845 8.3e-205 Neutral ceramidase OS=Drosophila melanogaster GN=CDase PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2232 Ceramidases Cluster-8309.44238 BP_3 1.00 0.37 421 861589141 KMQ82656.1 196 5.1e-13 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF01047 Transposase//MarR family GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44239 BP_3 5.28 2.69 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44240 BP_3 17.60 0.76 1403 607356391 EZA50914.1 232 1.1e-16 hypothetical protein X777_10741 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01047//PF01498 MarR family//Transposase GO:0015074//GO:0006313//GO:0006355 DNA integration//transposition, DNA-mediated//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44241 BP_3 4.00 0.54 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01493 GXGXG motif GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.44242 BP_3 2303.76 43.61 2838 642919346 XP_008191834.1 1839 1.1e-202 PREDICTED: uncharacterized protein LOC662079 [Tribolium castaneum]>gi|270005802|gb|EFA02250.1| hypothetical protein TcasGA2_TC007913 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.44244 BP_3 17.61 0.31 3050 282403501 NP_001164148.1 269 1.3e-20 fumble isoform 3 [Tribolium castaneum]>gi|270002881|gb|EEZ99328.1| fumble [Tribolium castaneum] -- -- -- -- -- K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q8K4K6 219 3.3e-16 Pantothenate kinase 1 OS=Mus musculus GN=Pank1 PE=1 SV=1 PF03630//PF00325 Fumble//Bacterial regulatory proteins, crp family GO:0015937//GO:0006355//GO:0015940 coenzyme A biosynthetic process//regulation of transcription, DNA-templated//pantothenate biosynthetic process GO:0005524//GO:0004594//GO:0003677 ATP binding//pantothenate kinase activity//DNA binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.44246 BP_3 122.95 2.90 2338 642919917 XP_008192124.1 1050 2.7e-111 PREDICTED: transmembrane 7 superfamily member 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS93 457 6.4e-44 Transmembrane 7 superfamily member 3 OS=Homo sapiens GN=TM7SF3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4425 BP_3 62.00 2.40 1537 -- -- -- -- -- 462468310 APGK01003484.1 63 6.552e-22 Dendroctonus ponderosae Seq01003484, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44250 BP_3 7.00 0.37 1202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44252 BP_3 82.09 1.23 3502 642921967 XP_008192964.1 947 3.5e-99 PREDICTED: protein painting of fourth isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W123 294 7.6e-25 Protein painting of fourth OS=Drosophila melanogaster GN=Pof PE=1 SV=1 PF01757//PF00076 Acyltransferase family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0016747//GO:0003676 transferase activity, transferring acyl groups other than amino-acyl groups//nucleic acid binding -- -- -- -- Cluster-8309.44254 BP_3 89.73 1.21 3861 642923462 XP_008193755.1 1023 6.0e-108 PREDICTED: forkhead box protein L2-like isoform X1 [Tribolium castaneum] 507561117 XM_004664203.1 146 1.20991e-67 PREDICTED: Jaculus jaculus forkhead box L2 (Foxl2), mRNA K09405 FOXL forkhead box protein L http://www.genome.jp/dbget-bin/www_bget?ko:K09405 O88470 395 1.6e-36 Forkhead box protein L2 OS=Mus musculus GN=Foxl2 PE=1 SV=2 PF00250//PF06070 Forkhead domain//Herpesvirus large structural phosphoprotein UL32 GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005198//GO:0043565 transcription factor activity, sequence-specific DNA binding//structural molecule activity//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44256 BP_3 10.00 0.57 1138 270003872 EFA00320.1 327 8.9e-28 hypothetical protein TcasGA2_TC003158 [Tribolium castaneum] 170037221 XM_001846406.1 83 3.67173e-33 Culex quinquefasciatus chloride channel protein 3, mRNA K05012 CLCN3_4_5 chloride channel 3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K05012 P51790 258 3.7e-21 H(+)/Cl(-) exchange transporter 3 OS=Homo sapiens GN=CLCN3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0475 Cl- channel CLC-3 and related proteins (CLC superfamily) Cluster-8309.44258 BP_3 117.55 0.50 11641 642920053 XP_008192184.1 1927 2.7e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.93838e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.9e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF03822//PF08159//PF00583//PF13508//PF08445//PF03396//PF02297//PF00341//PF13673//PF00159 NAF domain//NUC153 domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Cytochrome oxidase c subunit VIb//PDGF/VEGF domain//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide GO:0006206//GO:0006144//GO:0008283//GO:0040007//GO:0006351//GO:0015992//GO:0042967//GO:0006123//GO:0007165//GO:0019083 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//cell proliferation//growth//transcription, DNA-templated//proton transport//acyl-carrier-protein biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//viral transcription GO:0004129//GO:0016747//GO:0008080//GO:0005179//GO:0008083//GO:0003677//GO:0003899 cytochrome-c oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//hormone activity//growth factor activity//DNA binding//DNA-directed RNA polymerase activity GO:0005576//GO:0016020//GO:0045277//GO:0005634//GO:0005730//GO:0005739 extracellular region//membrane//respiratory chain complex IV//nucleus//nucleolus//mitochondrion KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.44259 BP_3 67.73 1.55 2403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00681 Plectin repeat -- -- -- -- GO:0005856 cytoskeleton -- -- Cluster-8309.44260 BP_3 124.62 2.39 2800 270007326 EFA03774.1 1530 7.0e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 843 1.3e-88 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF08066//PF02456//PF01612 PMC2NT (NUC016) domain//Adenovirus IVa2 protein//3'-5' exonuclease GO:0006139//GO:0006396//GO:0019083 nucleobase-containing compound metabolic process//RNA processing//viral transcription GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.44261 BP_3 359.26 6.71 2874 91094369 XP_970631.1 1029 8.9e-109 PREDICTED: E3 ubiquitin-protein ligase znrf1 [Tribolium castaneum] -- -- -- -- -- K10694 ZNRF1_2 E3 ubiquitin-protein ligase ZNRF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10694 Q71FD5 435 2.8e-41 E3 ubiquitin-protein ligase ZNRF2 OS=Mus musculus GN=Znrf2 PE=1 SV=1 PF13639//PF01612//PF15926//PF14634//PF12678//PF12906//PF17123//PF00097 Ring finger domain//3'-5' exonuclease//E3 ubiquitin-protein ligase RNF220//zinc-RING finger domain//RING-H2 zinc finger//RING-variant domain//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0006139//GO:0090263 protein ubiquitination//nucleobase-containing compound metabolic process//positive regulation of canonical Wnt signaling pathway GO:0005515//GO:0046872//GO:0008270//GO:0003676//GO:0008408 protein binding//metal ion binding//zinc ion binding//nucleic acid binding//3'-5' exonuclease activity -- -- KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.44263 BP_3 200.96 2.60 4014 270009986 EFA06434.1 1590 1.1e-173 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.9e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF03359//PF02653//PF01544 Guanylate-kinase-associated protein (GKAP) protein//Branched-chain amino acid transport system / permease component//CorA-like Mg2+ transporter protein GO:0006810//GO:0030001//GO:0023052//GO:0055085 transport//metal ion transport//signaling//transmembrane transport GO:0005215//GO:0046873 transporter activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.44264 BP_3 205.20 2.52 4219 642922624 XP_008193254.1 3643 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] 642922625 XM_008195033.1 226 4.46534e-112 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07291 Methylamine utilisation protein MauE GO:0030416 methylamine metabolic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.44265 BP_3 58.63 0.70 4325 -- -- -- -- -- 642922625 XM_008195033.1 61 2.41945e-20 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF08001 CMV US GO:0030683 evasion or tolerance by virus of host immune response -- -- GO:0044386 integral to host endoplasmic reticulum membrane -- -- Cluster-8309.44266 BP_3 91.44 1.30 3680 642933135 XP_973578.2 3446 0.0e+00 PREDICTED: DNA topoisomerase 3-alpha [Tribolium castaneum] 571572814 XM_394050.5 155 1.14453e-72 PREDICTED: Apis mellifera DNA topoisomerase 3-alpha-like (LOC410571), mRNA K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 Q9NG98 2222 2.2e-248 DNA topoisomerase 3-alpha OS=Drosophila melanogaster GN=Top3alpha PE=2 SV=2 PF06839//PF01022//PF00556//PF01131//PF01396 GRF zinc finger//Bacterial regulatory protein, arsR family//Antenna complex alpha/beta subunit//DNA topoisomerase//Topoisomerase DNA binding C4 zinc finger GO:0019684//GO:0006265//GO:0006118//GO:0006355 photosynthesis, light reaction//DNA topological change//obsolete electron transport//regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0003916//GO:0045156//GO:0003677 transcription factor activity, sequence-specific DNA binding//zinc ion binding//DNA topoisomerase activity//electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//DNA binding GO:0005694//GO:0005667//GO:0030077//GO:0016021 chromosome//transcription factor complex//plasma membrane light-harvesting complex//integral component of membrane KOG1956 DNA topoisomerase III alpha Cluster-8309.44267 BP_3 3.00 0.51 576 332373118 AEE61700.1 141 1.7e-06 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44270 BP_3 48.82 1.00 2645 332376210 AEE63245.1 1265 3.5e-136 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XJP1 688 1.2e-70 Protein TSSC1 OS=Danio rerio GN=tssc1 PE=2 SV=1 PF00400//PF03121//PF01215 WD domain, G-beta repeat//Herpesviridae UL52/UL70 DNA primase//Cytochrome c oxidase subunit Vb GO:0015992//GO:0006269//GO:0006260//GO:0006351//GO:0006123 proton transport//DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0005515//GO:0003896 cytochrome-c oxidase activity//protein binding//DNA primase activity GO:0005730//GO:0005740//GO:0045277//GO:0005657 nucleolus//mitochondrial envelope//respiratory chain complex IV//replication fork KOG1007 WD repeat protein TSSC1, WD repeat superfamily Cluster-8309.44271 BP_3 232.53 2.08 5672 270009170 EFA05618.1 2269 2.9e-252 hypothetical protein TcasGA2_TC015826 [Tribolium castaneum] 768423227 XM_011554208.1 242 7.67338e-121 PREDICTED: Plutella xylostella histone-lysine N-methyltransferase SETD1-like (LOC105384048), mRNA K11422 SETD1, SET1 histone-lysine N-methyltransferase SETD1 http://www.genome.jp/dbget-bin/www_bget?ko:K11422 Q5LJZ2 1105 1.1e-118 Histone-lysine N-methyltransferase SETD1 OS=Drosophila melanogaster GN=Set1 PE=1 SV=1 PF00856//PF00076//PF03490 SET domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396//GO:0005515//GO:0003676 glycosylphosphatidylinositol diacylglycerol-lyase activity//protein binding//nucleic acid binding -- -- KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.44274 BP_3 485.19 1.50 15832 642934437 XP_008197662.1 5528 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X1 [Tribolium castaneum]>gi|270013709|gb|EFA10157.1| hypothetical protein TcasGA2_TC012345 [Tribolium castaneum] 242013552 XM_002427424.1 127 1.82131e-56 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1577 5.8e-173 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00439//PF00202//PF00628//PF16866//PF04947//PF13639//PF02178//PF00155//PF12125 Bromodomain//Aminotransferase class-III//PHD-finger//PHD-finger//Poxvirus Late Transcription Factor VLTF3 like//Ring finger domain//AT hook motif//Aminotransferase class I and II//D domain of beta-TrCP GO:0009058//GO:0046782 biosynthetic process//regulation of viral transcription GO:0005488//GO:0008270//GO:0046983//GO:0030170//GO:0008483//GO:0005515//GO:0003677 binding//zinc ion binding//protein dimerization activity//pyridoxal phosphate binding//transaminase activity//protein binding//DNA binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.44275 BP_3 281.55 0.89 15482 642934437 XP_008197662.1 5528 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X1 [Tribolium castaneum]>gi|270013709|gb|EFA10157.1| hypothetical protein TcasGA2_TC012345 [Tribolium castaneum] 242013552 XM_002427424.1 127 1.78095e-56 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1577 5.7e-173 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00155//PF02178//PF13639//PF12125//PF00439//PF16866//PF00628//PF00202 Aminotransferase class I and II//AT hook motif//Ring finger domain//D domain of beta-TrCP//Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III GO:0009058 biosynthetic process GO:0003677//GO:0030170//GO:0046983//GO:0005515//GO:0008483//GO:0005488//GO:0008270 DNA binding//pyridoxal phosphate binding//protein dimerization activity//protein binding//transaminase activity//binding//zinc ion binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.44276 BP_3 1591.72 22.01 3778 646701548 KDR11217.1 3060 0.0e+00 E3 ubiquitin-protein ligase Nedd-4 [Zootermopsis nevadensis] -- -- -- -- -- K10591 NEDD4, RSP5 E3 ubiquitin-protein ligase NEDD4 http://www.genome.jp/dbget-bin/www_bget?ko:K10591 Q9VVI3 2157 7.7e-241 E3 ubiquitin-protein ligase Nedd-4 OS=Drosophila melanogaster GN=Nedd4 PE=1 SV=2 PF00632//PF00168//PF00397 HECT-domain (ubiquitin-transferase)//C2 domain//WW domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.44277 BP_3 11.00 0.37 1741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44278 BP_3 144.97 1.31 5612 546671797 ERL83955.1 1541 7.5e-168 hypothetical protein D910_01250 [Dendroctonus ponderosae] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 1026 1.6e-109 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF00245//PF01035//PF01676//PF00884//PF01663//PF01355 Alkaline phosphatase//6-O-methylguanine DNA methyltransferase, DNA binding domain//Metalloenzyme superfamily//Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//High potential iron-sulfur protein GO:0008152//GO:0019646//GO:0006281//GO:0006118 metabolic process//aerobic electron transport chain//DNA repair//obsolete electron transport GO:0003824//GO:0016791//GO:0009055//GO:0008484//GO:0046872 catalytic activity//phosphatase activity//electron carrier activity//sulfuric ester hydrolase activity//metal ion binding -- -- -- -- Cluster-8309.44279 BP_3 132.00 22.53 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44280 BP_3 15.31 0.64 1444 642928561 XP_008199958.1 648 6.8e-65 PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928563|ref|XP_008199959.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928565|ref|XP_008199960.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270011133|gb|EFA07581.1| cytochrome P450 12H1 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 517 4.3e-51 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067//PF00640 Cytochrome P450//Phosphotyrosine interaction domain (PTB/PID) GO:0055114 oxidation-reduction process GO:0020037//GO:0005515//GO:0005506//GO:0016705 heme binding//protein binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.44281 BP_3 325.51 3.35 4977 642910291 XP_008198710.1 3584 0.0e+00 PREDICTED: guanine nucleotide exchange factor DBS-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63406 1738 3.9e-192 Guanine nucleotide exchange factor DBS OS=Rattus norvegicus GN=Mcf2l PE=1 SV=3 PF00435//PF00018//PF14604//PF00621//PF00806 Spectrin repeat//SH3 domain//Variant SH3 domain//RhoGEF domain//Pumilio-family RNA binding repeat GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089//GO:0003723 protein binding//Rho guanyl-nucleotide exchange factor activity//RNA binding -- -- -- -- Cluster-8309.44282 BP_3 237.95 3.18 3896 642910291 XP_008198710.1 1797 1.1e-197 PREDICTED: guanine nucleotide exchange factor DBS-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44283 BP_3 395.22 5.92 3512 270005700 EFA02148.1 294 1.8e-23 hypothetical protein TcasGA2_TC007800 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15003//PF04625//PF09036//PF01484 HAUS augmin-like complex subunit 2//DEC-1 protein, N-terminal region//Bcr-Abl oncoprotein oligomerisation domain//Nematode cuticle collagen N-terminal domain GO:0007304//GO:0016310//GO:0006468//GO:0031023//GO:0009069//GO:0007165//GO:0051225 chorion-containing eggshell formation//phosphorylation//protein phosphorylation//microtubule organizing center organization//serine family amino acid metabolic process//signal transduction//spindle assembly GO:0004674//GO:0042302//GO:0005096//GO:0005213 protein serine/threonine kinase activity//structural constituent of cuticle//GTPase activator activity//structural constituent of chorion GO:0042600//GO:0005576 chorion//extracellular region -- -- Cluster-8309.44288 BP_3 137.00 4.21 1859 642923877 XP_008193910.1 439 1.5e-40 PREDICTED: aristaless isoform X1 [Tribolium castaneum] -- -- -- -- -- K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44289 BP_3 121.47 1.17 5302 189239596 XP_967754.2 1896 4.8e-209 PREDICTED: BTB/POZ domain-containing protein KCTD3 [Tribolium castaneum]>gi|270010663|gb|EFA07111.1| hypothetical protein TcasGA2_TC010101 [Tribolium castaneum] 170042981 XM_001849132.1 104 3.70915e-44 Culex quinquefasciatus BTB/POZ domain-containing protein KCTD3, mRNA -- -- -- -- Q8BFX3 921 2.3e-97 BTB/POZ domain-containing protein KCTD3 OS=Mus musculus GN=Kctd3 PE=2 SV=1 PF00651//PF09726//PF02214 BTB/POZ domain//Transmembrane protein//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding GO:0016021 integral component of membrane KOG2714 SETA binding protein SB1 and related proteins, contain BTB/POZ domain Cluster-8309.44290 BP_3 745.82 5.94 6345 91078808 XP_970433.1 2223 7.0e-247 PREDICTED: protein SDA1 homolog [Tribolium castaneum]>gi|270004115|gb|EFA00563.1| hypothetical protein TcasGA2_TC003433 [Tribolium castaneum] -- -- -- -- -- K14856 SDA1, SDAD1 protein SDA1 http://www.genome.jp/dbget-bin/www_bget?ko:K14856 Q7KKH3 1747 4.5e-193 Protein SDA1 homolog OS=Drosophila melanogaster GN=Mys45A PE=1 SV=1 PF07690//PF06839//PF01306 Major Facilitator Superfamily//GRF zinc finger//LacY proton/sugar symporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0008270 zinc ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG2229 Protein required for actin cytoskeleton organization and cell cycle progression Cluster-8309.44293 BP_3 791.00 8.05 5028 642918835 XP_008191606.1 5206 0.0e+00 PREDICTED: DENN domain-containing protein 5B [Tribolium castaneum]>gi|270005624|gb|EFA02072.1| hypothetical protein TcasGA2_TC007707 [Tribolium castaneum] 571543384 XM_006559642.1 37 6.18248e-07 PREDICTED: Apis mellifera DENN domain-containing protein 5B-like (LOC412128), transcript variant X4, mRNA -- -- -- -- Q6ZUT9 2374 7.0e-266 DENN domain-containing protein 5B OS=Homo sapiens GN=DENND5B PE=1 SV=2 PF01807//PF01477 CHC2 zinc finger//PLAT/LH2 domain GO:0006269//GO:0006260//GO:0006351 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated GO:0008270//GO:0005515//GO:0003896//GO:0003677 zinc ion binding//protein binding//DNA primase activity//DNA binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2080 Uncharacterized conserved protein, contains DENN and RUN domains Cluster-8309.44294 BP_3 35.65 0.35 5179 642918835 XP_008191606.1 4683 0.0e+00 PREDICTED: DENN domain-containing protein 5B [Tribolium castaneum]>gi|270005624|gb|EFA02072.1| hypothetical protein TcasGA2_TC007707 [Tribolium castaneum] 571543384 XM_006559642.1 37 6.36949e-07 PREDICTED: Apis mellifera DENN domain-containing protein 5B-like (LOC412128), transcript variant X4, mRNA -- -- -- -- Q6ZUT9 2258 2.0e-252 DENN domain-containing protein 5B OS=Homo sapiens GN=DENND5B PE=1 SV=2 PF01807//PF01477 CHC2 zinc finger//PLAT/LH2 domain GO:0006260//GO:0006269//GO:0006351 DNA replication//DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0008270//GO:0005515//GO:0003896//GO:0003677 zinc ion binding//protein binding//DNA primase activity//DNA binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2080 Uncharacterized conserved protein, contains DENN and RUN domains Cluster-8309.44297 BP_3 140.55 2.44 3067 270000862 EEZ97309.1 900 8.7e-94 hypothetical protein TcasGA2_TC011118 [Tribolium castaneum] 195590478 XM_002084937.1 97 1.6621e-40 Drosophila simulans GD14552 (Dsim\GD14552), mRNA K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 P29747 388 8.4e-36 Cyclic AMP response element-binding protein A OS=Drosophila melanogaster GN=CrebA PE=1 SV=2 PF02183//PF07716//PF03131//PF07926//PF01544//PF00170//PF06005//PF04111 Homeobox associated leucine zipper//Basic region leucine zipper//bZIP Maf transcription factor//TPR/MLP1/MLP2-like protein//CorA-like Mg2+ transporter protein//bZIP transcription factor//Protein of unknown function (DUF904)//Autophagy protein Apg6 GO:0006914//GO:0030001//GO:0055085//GO:0000917//GO:0043093//GO:0006606//GO:0006355 autophagy//metal ion transport//transmembrane transport//barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565//GO:0046873 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//metal ion transmembrane transporter activity GO:0005667//GO:0005634//GO:0005737//GO:0016020 transcription factor complex//nucleus//cytoplasm//membrane KOG0709 CREB/ATF family transcription factor Cluster-8309.44298 BP_3 43.95 0.79 2961 270011776 EFA08224.1 722 3.7e-73 hypothetical protein TcasGA2_TC005851 [Tribolium castaneum] -- -- -- -- -- K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 347 4.6e-31 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF02188 BTB/POZ domain//GoLoco motif -- -- GO:0030695//GO:0005515 GTPase regulator activity//protein binding -- -- -- -- Cluster-8309.443 BP_3 3.00 0.40 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44300 BP_3 129.00 2.13 3216 642931624 XP_008196660.1 331 8.7e-28 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13639//PF13465//PF00096//PF16622//PF02892//PF13912 Ring finger domain//Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0003677//GO:0008270//GO:0005515//GO:0046872 DNA binding//zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.44303 BP_3 909.99 12.90 3693 642934510 XP_008197694.1 3479 0.0e+00 PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|642934512|ref|XP_008197695.1| PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|270013512|gb|EFA09960.1| hypothetical protein TcasGA2_TC012117 [Tribolium castaneum] 393809286 JQ824200.1 481 0 Bombyx mori adaptor protein complex-1 gamma subunit (AP1G) mRNA, complete cds, alternatively spliced K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 2321 7.2e-260 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF02883//PF02985//PF08367//PF01602 Adaptin C-terminal domain//HEAT repeat//Peptidase M16C associated//Adaptin N terminal region GO:0015031//GO:0006508//GO:0006886//GO:0016192 protein transport//proteolysis//intracellular protein transport//vesicle-mediated transport GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0030117//GO:0044431//GO:0030131 membrane coat//Golgi apparatus part//clathrin adaptor complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.44304 BP_3 1098.00 6.06 9025 642913467 XP_008201025.1 3247 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC664116 [Tribolium castaneum] 642913466 XM_008202803.1 409 0 PREDICTED: Tribolium castaneum uncharacterized LOC664116 (LOC664116), mRNA -- -- -- -- Q5BJU7 192 1.3e-12 Wiskott-Aldrich syndrome protein family member 1 OS=Rattus norvegicus GN=Wasf1 PE=1 SV=1 PF04013 Putative SAM-dependent RNA methyltransferase GO:0008033//GO:0009451 tRNA processing//RNA modification GO:0008175 tRNA methyltransferase activity -- -- KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.44307 BP_3 21.99 0.33 3478 385845164 AFI81409.1 798 6.6e-82 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 57 3.24908e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 412 1.6e-38 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF08127//PF03099 Peptidase family C1 propeptide//Biotin/lipoate A/B protein ligase family GO:0050790//GO:0006464//GO:0006508 regulation of catalytic activity//cellular protein modification process//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.44308 BP_3 40.08 0.45 4540 478258212 ENN78341.1 2151 1.1e-238 hypothetical protein YQE_05143, partial [Dendroctonus ponderosae]>gi|546677008|gb|ERL87924.1| hypothetical protein D910_05312 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R7U0 1006 2.7e-107 Transmembrane channel-like protein 7 OS=Macaca fascicularis GN=TMC7 PE=2 SV=1 PF08686//PF07810 PLAC (protease and lacunin) domain//TMC domain -- -- GO:0008233 peptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.44309 BP_3 21.17 0.46 2500 546678697 ERL89265.1 1371 1.7e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 3.1e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.4431 BP_3 121.19 2.61 2527 642928107 XP_008200159.1 534 2.0e-51 PREDICTED: SAGA-associated factor 11 homolog [Tribolium castaneum]>gi|270010861|gb|EFA07309.1| hypothetical protein TcasGA2_TC015900 [Tribolium castaneum] -- -- -- -- -- K11363 SGF11 SAGA-associated factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11363 B0W8L4 238 1.7e-18 SAGA-associated factor 11 homolog OS=Culex quinquefasciatus GN=Sgf11 PE=3 SV=1 PF11522 Yeast phosphatidylinositol-4-OH kinase Pik1 -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.44311 BP_3 6.60 2.95 398 642911935 XP_008199028.1 270 1.3e-21 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 5-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00558//PF14942 Vpu protein//Organelle biogenesis, Muted-like protein GO:0019076//GO:0032801//GO:0006812 viral release from host cell//receptor catabolic process//cation transport GO:0005261 cation channel activity GO:0030133//GO:0033644//GO:0031083 transport vesicle//host cell membrane//BLOC-1 complex -- -- Cluster-8309.44312 BP_3 59153.36 1269.28 2538 91093831 XP_966868.1 430 2.3e-39 PREDICTED: proline-rich protein 4-like [Tribolium castaneum] 642938794 XM_961775.2 143 3.68477e-66 PREDICTED: Tribolium castaneum proline-rich protein 4-like (LOC657696), mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q9VLJ6 262 2.8e-21 Angiotensin-converting enzyme-related protein OS=Drosophila melanogaster GN=Acer PE=1 SV=1 PF00879//PF01401 Defensin propeptide//Angiotensin-converting enzyme GO:0006952//GO:0006508 defense response//proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane -- -- Cluster-8309.44315 BP_3 592.53 11.24 2832 642933086 XP_008197254.1 1618 4.4e-177 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 1020 4.0e-109 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133//PF03171 Tubulin-tyrosine ligase family//2OG-Fe(II) oxygenase superfamily GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.44316 BP_3 164.33 0.90 9089 91076206 XP_972459.1 2316 1.6e-257 PREDICTED: KN motif and ankyrin repeat domain-containing protein 2 [Tribolium castaneum]>gi|270014552|gb|EFA11000.1| hypothetical protein TcasGA2_TC004585 [Tribolium castaneum] 759076887 XM_011349892.1 70 5.06871e-25 PREDICTED: Cerapachys biroi KN motif and ankyrin repeat domain-containing protein 2-like (LOC105285603), transcript variant X3, mRNA -- -- -- -- Q14678 663 3.2e-67 KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens GN=KANK1 PE=1 SV=3 PF15182//PF13606//PF00628//PF07649//PF02150//PF15898//PF01096//PF01300//PF00023//PF13939//PF01363 Otospiralin//Ankyrin repeat//PHD-finger//C1-like domain//RNA polymerases M/15 Kd subunit//cGMP-dependent protein kinase interacting domain//Transcription factor S-II (TFIIS)//Telomere recombination//Ankyrin repeat//Toxin TisB, type I toxin-antitoxin system//FYVE zinc finger GO:0006820//GO:0006206//GO:0009432//GO:0006144//GO:0006351//GO:0022611//GO:0055114//GO:0007605 anion transport//pyrimidine nucleobase metabolic process//SOS response//purine nucleobase metabolic process//transcription, DNA-templated//dormancy process//oxidation-reduction process//sensory perception of sound GO:0046872//GO:0003676//GO:0005515//GO:0003677//GO:0003725//GO:0047134//GO:0005253//GO:0019901//GO:0008270//GO:0003899 metal ion binding//nucleic acid binding//protein binding//DNA binding//double-stranded RNA binding//protein-disulfide reductase activity//anion channel activity//protein kinase binding//zinc ion binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005887 nucleolus//integral component of plasma membrane KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.44319 BP_3 9.00 1.01 721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4432 BP_3 40.81 1.00 2250 642928107 XP_008200159.1 534 1.8e-51 PREDICTED: SAGA-associated factor 11 homolog [Tribolium castaneum]>gi|270010861|gb|EFA07309.1| hypothetical protein TcasGA2_TC015900 [Tribolium castaneum] -- -- -- -- -- K11363 SGF11 SAGA-associated factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11363 B0W8L4 238 1.5e-18 SAGA-associated factor 11 homolog OS=Culex quinquefasciatus GN=Sgf11 PE=3 SV=1 PF11522 Yeast phosphatidylinositol-4-OH kinase Pik1 -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.44321 BP_3 16.73 0.32 2787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07578//PF14895 Lipid A Biosynthesis N-terminal domain//Protein phosphatase 1 inhibitor GO:0009245//GO:0010923 lipid A biosynthetic process//negative regulation of phosphatase activity GO:0019902//GO:0008915 phosphatase binding//lipid-A-disaccharide synthase activity -- -- -- -- Cluster-8309.44322 BP_3 96.00 1.21 4108 642914043 XP_008201521.1 3397 0.0e+00 PREDICTED: metabotropic glutamate receptor 5-like [Tribolium castaneum]>gi|270002144|gb|EEZ98591.1| hypothetical protein TcasGA2_TC001106 [Tribolium castaneum] 852783725 XM_013028106.1 66 3.81667e-23 PREDICTED: Dipodomys ordii glutamate receptor, metabotropic 2 (Grm2), mRNA K04604 GRM5 metabotropic glutamate receptor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04604 P31424 2041 2.4e-227 Metabotropic glutamate receptor 5 OS=Rattus norvegicus GN=Grm5 PE=1 SV=2 PF01620//PF00003//PF02687//PF07562 Ribonuclease (pollen allergen)//7 transmembrane sweet-taste receptor of 3 GCPR//FtsX-like permease family//Nine Cysteines Domain of family 3 GPCR GO:0016068//GO:0007186 type I hypersensitivity//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.44323 BP_3 444.02 2.42 9146 815898955 XP_012250113.1 3448 0.0e+00 PREDICTED: metabotropic glutamate receptor 2 isoform X2 [Bombus impatiens] 827545296 XM_004925338.2 134 1.34964e-60 PREDICTED: Bombyx mori metabotropic glutamate receptor 2-like (LOC101737989), mRNA K04611 MXR metabotropic X receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04611 O00222 1625 9.1e-179 Metabotropic glutamate receptor 8 OS=Homo sapiens GN=GRM8 PE=2 SV=2 PF00003//PF07690//PF09198//PF07562 7 transmembrane sweet-taste receptor of 3 GCPR//Major Facilitator Superfamily//Bacteriophage T4 beta-glucosyltransferase//Nine Cysteines Domain of family 3 GPCR GO:0006304//GO:0055085//GO:0007186 DNA modification//transmembrane transport//G-protein coupled receptor signaling pathway GO:0033821//GO:0004930 DNA beta-glucosyltransferase activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.44326 BP_3 417.32 9.23 2472 189238013 XP_001813375.1 2647 1.9e-296 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 55 2.9767e-17 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1925 4.0e-214 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00664//PF13304//PF06414//PF00005//PF03193//PF00437 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//ABC transporter//Protein of unknown function, DUF258//Type II/IV secretion system protein GO:0006810//GO:0006200//GO:0055085 transport//obsolete ATP catabolic process//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0016301//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTP binding GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.44328 BP_3 44.46 0.99 2456 189238013 XP_001813375.1 2718 1.1e-304 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 55 2.95716e-17 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1926 3.1e-214 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00437//PF06414//PF13304//PF00664//PF03193//PF00005 Type II/IV secretion system protein//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0055085//GO:0006200//GO:0006810 transmembrane transport//obsolete ATP catabolic process//transport GO:0016887//GO:0016301//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.44329 BP_3 22.31 0.46 2618 189238013 XP_001813375.1 1531 5.0e-167 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 52 1.46789e-15 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1142 2.6e-123 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00437//PF00005//PF07728//PF03193//PF00664//PF13304//PF06414 Type II/IV secretion system protein//ABC transporter//AAA domain (dynein-related subfamily)//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin GO:0055085//GO:0006200//GO:0006810 transmembrane transport//obsolete ATP catabolic process//transport GO:0005524//GO:0003924//GO:0005525//GO:0016301//GO:0016887//GO:0042626 ATP binding//GTPase activity//GTP binding//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.44334 BP_3 1204.91 6.48 9249 189235087 XP_001808767.1 4590 0.0e+00 PREDICTED: leucine-rich repeat-containing protein 16A [Tribolium castaneum] 808129414 XM_003397808.2 142 4.87447e-65 PREDICTED: Bombus terrestris DNA/RNA-binding protein KIN17 (LOC100644094), mRNA -- -- -- -- Q5VZK9 1592 6.2e-175 Leucine-rich repeat-containing protein 16A OS=Homo sapiens GN=LRRC16A PE=1 SV=1 PF00560//PF07062 Leucine Rich Repeat//Clc-like -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2837 Protein containing a U1-type Zn-finger and implicated in RNA splicing or processing Cluster-8309.44335 BP_3 47.74 1.08 2424 642930224 XP_008196307.1 2188 3.0e-243 PREDICTED: probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [Tribolium castaneum] 543271752 XM_005425019.1 98 3.64357e-41 PREDICTED: Geospiza fortis methylcrotonoyl-CoA carboxylase beta chain, mitochondrial-like (LOC102043970), mRNA K01969 E6.4.1.4B 3-methylcrotonyl-CoA carboxylase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01969 Q9V9A7 1889 5.9e-210 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Drosophila melanogaster GN=l(2)04524 PE=2 SV=1 PF00484//PF10186//PF06833 Carbonic anhydrase//Vacuolar sorting 38 and autophagy-related subunit 14//Malonate decarboxylase gamma subunit (MdcE) GO:0006807//GO:0010508//GO:0006730 nitrogen compound metabolic process//positive regulation of autophagy//one-carbon metabolic process GO:0016874//GO:0004089//GO:0008270 ligase activity//carbonate dehydratase activity//zinc ion binding -- -- KOG0540 3-Methylcrotonyl-CoA carboxylase, non-biotin containing subunit/Acetyl-CoA carboxylase carboxyl transferase, subunit beta Cluster-8309.44336 BP_3 186.77 6.44 1690 478259929 ENN79731.1 747 2.6e-76 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 407 2.9e-38 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.44337 BP_3 659.13 5.29 6297 642929205 XP_008195735.1 6293 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 848 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q9Y4E6 2954 0.0e+00 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF01506//PF00400 Hepatitis C virus non-structural 5a protein membrane anchor//WD domain, G-beta repeat GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0003968//GO:0004197//GO:0004252//GO:0017111//GO:0005515 RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//serine-type endopeptidase activity//nucleoside-triphosphatase activity//protein binding GO:0031379 RNA-directed RNA polymerase complex KOG4155 FOG: WD40 repeat Cluster-8309.44339 BP_3 876.02 6.88 6428 642918222 XP_008191418.1 7410 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 1 isoform X1 [Tribolium castaneum]>gi|270003291|gb|EEZ99738.1| hypothetical protein TcasGA2_TC002507 [Tribolium castaneum] 795022714 XM_012005302.1 590 0 PREDICTED: Vollenhovia emeryi transcription initiation factor TFIID subunit 1 (LOC105557903), mRNA K03125 TAF1 transcription initiation factor TFIID subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03125 Q8IZX4 3968 0.0e+00 Transcription initiation factor TFIID subunit 1-like OS=Homo sapiens GN=TAF1L PE=1 SV=1 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG0008 Transcription initiation factor TFIID, subunit TAF1 Cluster-8309.4434 BP_3 21.04 0.36 3084 164698398 NP_001106936.1 1532 4.5e-167 timeless isoform B [Tribolium castaneum]>gi|140270876|gb|ABO86541.1| TIMELESS isoform B [Tribolium castaneum] -- -- -- -- -- K12074 TIM timeless http://www.genome.jp/dbget-bin/www_bget?ko:K12074 P49021 1191 6.5e-129 Protein timeless OS=Drosophila melanogaster GN=tim PE=1 SV=3 PF06925 Monogalactosyldiacylglycerol (MGDG) synthase GO:0009247 glycolipid biosynthetic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44341 BP_3 3403.28 44.55 3974 546676181 ERL87248.1 2281 8.2e-254 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9J0 409 4.0e-38 Mycosubtilin synthase subunit B OS=Bacillus subtilis GN=mycB PE=3 SV=1 PF02733//PF00501 Dak1 domain//AMP-binding enzyme GO:0008152//GO:0046486//GO:0006071 metabolic process//glycerolipid metabolic process//glycerol metabolic process GO:0003824//GO:0004371 catalytic activity//glycerone kinase activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.44342 BP_3 30.00 0.33 4697 642925942 XP_008194705.1 4442 0.0e+00 PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3-like [Tribolium castaneum] 642925941 XM_008196483.1 58 1.2233e-18 PREDICTED: Tribolium castaneum voltage-dependent calcium channel subunit alpha-2/delta-3-like (LOC662338), mRNA K05316 CACNA2DN voltage-dependent calcium channel alpha-2/delta, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05316 Q7Z3S7 1097 7.8e-118 Voltage-dependent calcium channel subunit alpha-2/delta-4 OS=Homo sapiens GN=CACNA2D4 PE=1 SV=2 PF00469//PF06112 Negative factor, (F-Protein) or Nef//Gammaherpesvirus capsid protein -- -- GO:0005525 GTP binding GO:0019028 viral capsid KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.44351 BP_3 48.88 0.48 5168 189240067 XP_970199.2 2407 2.6e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.31863e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 5.2e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF00083//PF08040//PF07690//PF05480 Sugar (and other) transporter//MNLL subunit//Major Facilitator Superfamily//Staphylococcus haemolytic protein GO:0006118//GO:0009405//GO:0055085 obsolete electron transport//pathogenesis//transmembrane transport GO:0003954//GO:0022857 NADH dehydrogenase activity//transmembrane transporter activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.44353 BP_3 443.38 2.66 8329 642934565 XP_008197717.1 3682 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF01533//PF00069//PF06293//PF07714 Tospovirus nucleocapsid protein//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524//GO:0000166 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding//nucleotide binding GO:0019013//GO:0016020 viral nucleocapsid//membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.44354 BP_3 84.00 4.32 1229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44355 BP_3 40.46 0.43 4822 641650412 XP_008189476.1 529 1.4e-50 PREDICTED: zinc finger protein 2-like isoform X1 [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q02525 486 5.7e-47 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF13912//PF02892//PF07776//PF05191//PF13465//PF00096//PF01328 C2H2-type zinc finger//BED zinc finger//Zinc-finger associated domain (zf-AD)//Adenylate kinase, active site lid//Zinc-finger double domain//Zinc finger, C2H2 type//Peroxidase, family 2 GO:0006979//GO:0006804//GO:0046034//GO:0006144 response to oxidative stress//obsolete peroxidase reaction//ATP metabolic process//purine nucleobase metabolic process GO:0003677//GO:0004601//GO:0008270//GO:0004017//GO:0046872 DNA binding//peroxidase activity//zinc ion binding//adenylate kinase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.44358 BP_3 211.29 10.61 1252 242022723 XP_002431788.1 717 5.9e-73 papilin, putative [Pediculus humanus corporis]>gi|212517113|gb|EEB19050.1| papilin, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q868Z9 612 3.6e-62 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014//PF02226 Kunitz/Bovine pancreatic trypsin inhibitor domain//Picornavirus coat protein (VP4) -- -- GO:0004867//GO:0005198 serine-type endopeptidase inhibitor activity//structural molecule activity GO:0019028 viral capsid KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.44359 BP_3 175.58 1.88 4784 642915090 XP_008190408.1 1130 2.9e-120 PREDICTED: probable uridine-cytidine kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q9VC99 910 3.9e-96 Probable uridine-cytidine kinase OS=Drosophila melanogaster GN=CG6364 PE=3 SV=1 PF00485//PF06414//PF01121//PF09547//PF00437//PF07690//PF02224//PF00083//PF03810 Phosphoribulokinase / Uridine kinase family//Zeta toxin//Dephospho-CoA kinase//Stage IV sporulation protein A (spore_IV_A)//Type II/IV secretion system protein//Major Facilitator Superfamily//Cytidylate kinase//Sugar (and other) transporter//Importin-beta N-terminal domain GO:0015937//GO:0006886//GO:0006810//GO:0006139//GO:0015940//GO:0055085//GO:0043934//GO:0006206//GO:0008152 coenzyme A biosynthetic process//intracellular protein transport//transport//nucleobase-containing compound metabolic process//pantothenate biosynthetic process//transmembrane transport//sporulation//pyrimidine nucleobase metabolic process//metabolic process GO:0004127//GO:0016887//GO:0016301//GO:0005524//GO:0004140//GO:0008536//GO:0022857 cytidylate kinase activity//ATPase activity//kinase activity//ATP binding//dephospho-CoA kinase activity//Ran GTPase binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.44360 BP_3 312.29 11.64 1585 91082413 XP_976289.1 522 3.0e-50 PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922599|ref|XP_008193242.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922601|ref|XP_008193243.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922603|ref|XP_008193244.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922605|ref|XP_008193245.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922607|ref|XP_008193246.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|270007164|gb|EFA03612.1| hypothetical protein TcasGA2_TC013700 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44361 BP_3 51.86 0.90 3061 642915291 XP_008190557.1 1402 5.3e-152 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 656 7.0e-67 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.44362 BP_3 185.47 5.85 1820 642915291 XP_008190557.1 1278 7.6e-138 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 596 3.8e-60 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.44363 BP_3 2387.19 13.57 8771 642912633 XP_008200941.1 4927 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q96RL7 2069 2.9e-230 Vacuolar protein sorting-associated protein 13A OS=Homo sapiens GN=VPS13A PE=1 SV=2 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.44365 BP_3 276.00 12.24 1379 641658103 XP_008180598.1 716 8.5e-73 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8TAQ5 685 1.4e-70 Zinc finger protein 420 OS=Homo sapiens GN=ZNF420 PE=1 SV=1 PF00412//PF13912//PF15178//PF00346//PF02178//PF13465//PF07975//PF00096 LIM domain//C2H2-type zinc finger//Mitochondrial import receptor subunit TOM5 homolog//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//AT hook motif//Zinc-finger double domain//TFIIH C1-like domain//Zinc finger, C2H2 type GO:0006281//GO:0055114 DNA repair//oxidation-reduction process GO:0003677//GO:0051287//GO:0016651//GO:0008270//GO:0048038//GO:0046872 DNA binding//NAD binding//oxidoreductase activity, acting on NAD(P)H//zinc ion binding//quinone binding//metal ion binding GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.44366 BP_3 330.03 4.70 3679 91089675 XP_974428.1 1381 1.7e-149 PREDICTED: probable trans-2-enoyl-CoA reductase, mitochondrial [Tribolium castaneum]>gi|270012629|gb|EFA09077.1| hypothetical protein TcasGA2_TC006794 [Tribolium castaneum] -- -- -- -- -- K07512 MECR, NRBF1 mitochondrial trans-2-enoyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07512 Q9V6U9 1031 2.8e-110 Probable trans-2-enoyl-CoA reductase, mitochondrial OS=Drosophila melanogaster GN=CG16935 PE=3 SV=2 PF08240//PF00107 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0008270//GO:0000166//GO:0016491 zinc ion binding//nucleotide binding//oxidoreductase activity -- -- KOG0025 Zn2+-binding dehydrogenase (nuclear receptor binding factor-1) Cluster-8309.44367 BP_3 17.00 1.22 964 332373302 AEE61792.1 375 2.1e-33 unknown [Dendroctonus ponderosae]>gi|546684141|gb|ERL93846.1| hypothetical protein D910_11132 [Dendroctonus ponderosae] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 263 8.2e-22 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF04101//PF02432//PF00201 Glycosyltransferase family 28 C-terminal domain//Fimbrial, major and minor subunit//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152//GO:0007155 metabolic process//cell adhesion GO:0016758 transferase activity, transferring hexosyl groups GO:0009289 pilus -- -- Cluster-8309.44372 BP_3 199.17 5.66 1987 91090214 XP_967924.1 1409 5.3e-153 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P08541 585 7.8e-59 UDP-glucuronosyltransferase 2B2 OS=Rattus norvegicus GN=Ugt2b PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44375 BP_3 14.44 0.63 1392 270013462 EFA09910.1 1126 2.4e-120 hypothetical protein TcasGA2_TC012061 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q09426 424 2.5e-40 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Rattus norvegicus GN=Ugt8 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44377 BP_3 37.35 0.34 5607 270000722 EEZ97169.1 2106 2.3e-233 hypothetical protein TcasGA2_TC004356 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 1242 1.4e-134 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF00130//PF00621//PF14604//PF00018 Phorbol esters/diacylglycerol binding domain (C1 domain)//RhoGEF domain//Variant SH3 domain//SH3 domain GO:0035023//GO:0043087//GO:0035556 regulation of Rho protein signal transduction//regulation of GTPase activity//intracellular signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.44379 BP_3 574.22 1.43 19620 642937892 XP_008200345.1 18892 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 3.57072e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 10400 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF03488//PF01667//PF02806//PF04410//PF03875//PF02207 Nematode insulin-related peptide beta type//Ribosomal protein S27//Alpha amylase, C-terminal all-beta domain//Gar1/Naf1 RNA binding region//Statherin//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0001522//GO:0042254//GO:0005975//GO:0007165//GO:0030500//GO:0042742 translation//pseudouridine synthesis//ribosome biogenesis//carbohydrate metabolic process//signal transduction//regulation of bone mineralization//defense response to bacterium GO:0043169//GO:0005179//GO:0003824//GO:0003735//GO:0008270//GO:0046848 cation binding//hormone activity//catalytic activity//structural constituent of ribosome//zinc ion binding//hydroxyapatite binding GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1776 Zn-binding protein Push Cluster-8309.4438 BP_3 1.00 0.47 393 546683554 ERL93352.1 332 8.1e-29 hypothetical protein D910_10644 [Dendroctonus ponderosae] 167380901 XM_001735449.1 54 1.58253e-17 Entamoeba dispar SAW760 DNA polymerase delta catalytic subunit, putative EDI_244370 mRNA, complete cds K02327 POLD1 DNA polymerase delta subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02327 P54358 256 2.2e-21 DNA polymerase delta catalytic subunit OS=Drosophila melanogaster GN=DNApol-delta PE=2 SV=2 PF00136 DNA polymerase family B -- -- GO:0003677//GO:0000166 DNA binding//nucleotide binding -- -- KOG0969 DNA polymerase delta, catalytic subunit Cluster-8309.44382 BP_3 765.09 14.06 2915 332373440 AEE61861.1 1521 8.1e-166 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RDN7 1071 5.0e-115 Carboxypeptidase Q OS=Pongo abelii GN=CPQ PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2195 Transferrin receptor and related proteins containing the protease-associated (PA) domain Cluster-8309.44384 BP_3 28.68 0.31 4778 546678584 ERL89166.1 1205 5.8e-129 hypothetical protein D910_06541, partial [Dendroctonus ponderosae] -- -- -- -- -- K08002 MMP24 matrix metalloproteinase-24 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K08002 Q9GLE4 481 2.1e-46 Matrix metalloproteinase-14 OS=Bos taurus GN=MMP14 PE=2 SV=1 PF01400//PF07998//PF00413//PF10462//PF02691 Astacin (Peptidase family M12A)//Peptidase family M54//Matrixin//Peptidase M66//Vacuolating cyotoxin GO:0006508//GO:0009405 proteolysis//pathogenesis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0005576//GO:0031012 extracellular region//extracellular matrix -- -- Cluster-8309.44385 BP_3 22.85 1.00 1389 478254210 ENN74475.1 1424 6.8e-155 hypothetical protein YQE_08921, partial [Dendroctonus ponderosae] -- -- -- -- -- K02085 APC adenomatosis polyposis coli protein http://www.genome.jp/dbget-bin/www_bget?ko:K02085 P70478 882 2.0e-93 Adenomatous polyposis coli protein OS=Rattus norvegicus GN=Apc PE=1 SV=1 PF10280//PF00514//PF05972 Mediator complex protein//Armadillo/beta-catenin-like repeat//APC 15 residue motif GO:0006357//GO:0016055 regulation of transcription from RNA polymerase II promoter//Wnt signaling pathway GO:0008013//GO:0001104//GO:0005515 beta-catenin binding//RNA polymerase II transcription cofactor activity//protein binding GO:0016592//GO:0016342 mediator complex//catenin complex KOG2122 Beta-catenin-binding protein APC, contains ARM repeats Cluster-8309.44386 BP_3 38.32 2.29 1100 189234473 XP_001808764.1 1072 3.5e-114 PREDICTED: double-strand-break repair protein rad21 homolog isoform X1 [Tribolium castaneum]>gi|270002814|gb|EEZ99261.1| rad21 [Tribolium castaneum] 662206050 XM_008478247.1 93 9.7879e-39 PREDICTED: Diaphorina citri double-strand-break repair protein rad21 homolog (LOC103513421), mRNA K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 697 4.4e-72 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF04825//PF06766 N terminus of Rad21 / Rec8 like protein//Fungal hydrophobin -- -- GO:0005515 protein binding GO:0000228//GO:0005576 nuclear chromosome//extracellular region KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.44387 BP_3 888.06 32.87 1594 332373278 AEE61780.1 1520 5.8e-166 unknown [Dendroctonus ponderosae]>gi|546685176|gb|ERL94703.1| hypothetical protein D910_11977 [Dendroctonus ponderosae] -- -- -- -- -- K12164 UBA5, UBE1DC1 ubiquitin-like modifier-activating enzyme 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12164 B9VJ80 1329 3.3e-145 Ubiquitin-like modifier-activating enzyme 5 OS=Bombyx mori PE=2 SV=1 PF01494//PF03435//PF02558//PF02826//PF03721//PF00899//PF00831 FAD binding domain//Saccharopine dehydrogenase NADP binding domain//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//ThiF family//Ribosomal L29 protein GO:0055114//GO:0042254//GO:0015940//GO:0006412 oxidation-reduction process//ribosome biogenesis//pantothenate biosynthetic process//translation GO:0008677//GO:0003735//GO:0008641//GO:0071949//GO:0016491//GO:0051287//GO:0016616 2-dehydropantoate 2-reductase activity//structural constituent of ribosome//small protein activating enzyme activity//FAD binding//oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005622//GO:0005840 intracellular//ribosome KOG2336 Molybdopterin biosynthesis-related protein Cluster-8309.44389 BP_3 532.50 3.23 8243 270009943 EFA06391.1 325 1.1e-26 hypothetical protein TcasGA2_TC009269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009//PF00570//PF12356//PF12763 Telomerase ribonucleoprotein complex - RNA binding domain//HRDC domain//Protein of unknown function (DUF3643)//Cytoskeletal-regulatory complex EF hand GO:0032465//GO:0006278//GO:0016567//GO:0006915 regulation of cytokinesis//RNA-dependent DNA replication//protein ubiquitination//apoptotic process GO:0003964//GO:0005515//GO:0004842//GO:0003676 RNA-directed DNA polymerase activity//protein binding//ubiquitin-protein transferase activity//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.44390 BP_3 40.84 0.54 3916 189234531 XP_967948.2 892 9.4e-93 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 704 2.4e-72 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522//PF13520 Amino acid permease//Solute carrier family 12//Amino acid permease GO:0006811//GO:0003333//GO:0006810//GO:0006865//GO:0055085 ion transport//amino acid transmembrane transport//transport//amino acid transport//transmembrane transport GO:0005215//GO:0015171 transporter activity//amino acid transmembrane transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.44393 BP_3 1658.99 43.86 2115 91087035 XP_974421.1 1714 2.4e-188 PREDICTED: E3 ubiquitin-protein ligase synoviolin A [Tribolium castaneum]>gi|642929379|ref|XP_008195811.1| PREDICTED: E3 ubiquitin-protein ligase synoviolin A [Tribolium castaneum]>gi|642929381|ref|XP_008195812.1| PREDICTED: E3 ubiquitin-protein ligase synoviolin A [Tribolium castaneum]>gi|270010520|gb|EFA06968.1| hypothetical protein TcasGA2_TC009927 [Tribolium castaneum] 733931137 XM_010727931.1 111 1.88241e-48 PREDICTED: Meleagris gallopavo E3 ubiquitin-protein ligase synoviolin-like (LOC104916890), mRNA K10601 SYVN1, HRD1 E3 ubiquitin-protein ligase synoviolin http://www.genome.jp/dbget-bin/www_bget?ko:K10601 Q9DBY1 1238 1.6e-134 E3 ubiquitin-protein ligase synoviolin OS=Mus musculus GN=Syvn1 PE=1 SV=3 PF11789//PF14634//PF12906//PF12678//PF17123//PF17122//PF00097//PF13639//PF12861 Zinc-finger of the MIZ type in Nse subunit//zinc-RING finger domain//RING-variant domain//RING-H2 zinc finger//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0043169//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//cation binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.44394 BP_3 814.08 4.77 8526 478262704 ENN81251.1 2158 3.2e-239 hypothetical protein YQE_02345, partial [Dendroctonus ponderosae]>gi|546679053|gb|ERL89576.1| hypothetical protein D910_06941 [Dendroctonus ponderosae] 759080227 XM_011351649.1 232 4.1851e-115 PREDICTED: Cerapachys biroi uncharacterized LOC105286595 (LOC105286595), transcript variant X5, mRNA K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 P70182 1209 1.5e-130 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Mus musculus GN=Pip5k1a PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.44396 BP_3 372.94 5.11 3806 642925611 XP_008194640.1 2652 7.5e-297 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.7e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44397 BP_3 87.28 2.27 2142 91076406 XP_969383.1 1230 3.3e-132 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 768 5.0e-80 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.444 BP_3 13.00 1.65 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44400 BP_3 1169.45 7.67 7639 91085823 XP_974821.1 3077 0.0e+00 PREDICTED: bone morphogenetic protein receptor type-2 [Tribolium castaneum]>gi|270011027|gb|EFA07475.1| wishful thinking [Tribolium castaneum] -- -- -- -- -- K04671 BMPR2 bone morphogenetic protein receptor type-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04671 O35607 801 2.7e-83 Bone morphogenetic protein receptor type-2 OS=Mus musculus GN=Bmpr2 PE=1 SV=1 PF00069//PF01064//PF03460//PF03829//PF06221//PF07714 Protein kinase domain//Activin types I and II receptor domain//Nitrite/Sulfite reductase ferredoxin-like half domain//PTS system glucitol/sorbitol-specific IIA component//Putative zinc finger motif, C2HC5-type//Protein tyrosine kinase GO:0008643//GO:0016310//GO:0055114//GO:0009401//GO:0006355//GO:0006468//GO:0023014//GO:0009069//GO:0007178 carbohydrate transport//phosphorylation//oxidation-reduction process//phosphoenolpyruvate-dependent sugar phosphotransferase system//regulation of transcription, DNA-templated//protein phosphorylation//signal transduction by protein phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004672//GO:0008982//GO:0004675//GO:0005024//GO:0016491//GO:0008270//GO:0004702//GO:0005524 protein kinase activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//transmembrane receptor protein serine/threonine kinase activity//transforming growth factor beta-activated receptor activity//oxidoreductase activity//zinc ion binding//receptor signaling protein serine/threonine kinase activity//ATP binding GO:0016020//GO:0005634//GO:0005737//GO:0009357 membrane//nucleus//cytoplasm//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex -- -- Cluster-8309.44401 BP_3 822.45 8.15 5154 642919776 XP_008192060.1 5683 0.0e+00 PREDICTED: multidrug resistance-associated protein 7 [Tribolium castaneum] -- -- -- -- -- K05674 ABCC10 ATP-binding cassette, subfamily C (CFTR/MRP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05674 Q5T3U5 2041 3.0e-227 Multidrug resistance-associated protein 7 OS=Homo sapiens GN=ABCC10 PE=1 SV=1 PF01926//PF13304//PF00664//PF03193//PF00005//PF00004 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter//ATPase family associated with various cellular activities (AAA) GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.44402 BP_3 621.90 9.25 3533 91082077 XP_966548.1 1186 6.9e-127 PREDICTED: zinc finger CCCH domain-containing protein 10 [Tribolium castaneum]>gi|270007415|gb|EFA03863.1| hypothetical protein TcasGA2_TC013984 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96K80 323 3.3e-28 Zinc finger CCCH domain-containing protein 10 OS=Homo sapiens GN=ZC3H10 PE=1 SV=1 PF02183//PF16326//PF04977 Homeobox associated leucine zipper//ABC transporter C-terminal domain//Septum formation initiator GO:0007049//GO:0006355 cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0005488//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44403 BP_3 40.00 1.96 1273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44404 BP_3 189.78 3.39 2991 282158097 NP_001164092.1 989 4.1e-104 quaking related [Tribolium castaneum] -- -- -- -- -- K17843 KHDRBS2, SLM1 KH domain-containing, RNA-binding, signal transduction-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17843 Q920F3 502 4.9e-49 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Rattus norvegicus GN=Khdrbs2 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.44405 BP_3 42.52 0.41 5231 91094947 XP_968721.1 1275 4.9e-137 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 866 5.3e-91 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF02295//PF06815 Adenosine deaminase z-alpha domain//Reverse transcriptase connection domain GO:0006278//GO:0006807 RNA-dependent DNA replication//nitrogen compound metabolic process GO:0003964//GO:0003723//GO:0003726 RNA-directed DNA polymerase activity//RNA binding//double-stranded RNA adenosine deaminase activity -- -- KOG2432 Uncharacterized conserved protein Cluster-8309.44406 BP_3 490.13 9.14 2876 237681141 NP_001153713.1 2130 1.9e-236 glycerol kinase-like [Tribolium castaneum]>gi|270003063|gb|EEZ99510.1| hypothetical protein TcasGA2_TC000091 [Tribolium castaneum] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q14409 1486 3.8e-163 Putative glycerol kinase 3 OS=Homo sapiens GN=GK3P PE=5 SV=2 PF02782//PF00370 FGGY family of carbohydrate kinases, C-terminal domain//FGGY family of carbohydrate kinases, N-terminal domain GO:0006072//GO:0016310//GO:0046486//GO:0005975 glycerol-3-phosphate metabolic process//phosphorylation//glycerolipid metabolic process//carbohydrate metabolic process GO:0016773//GO:0004370 phosphotransferase activity, alcohol group as acceptor//glycerol kinase activity -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.44408 BP_3 933.71 6.44 7281 642930496 XP_008196428.1 2252 3.5e-250 PREDICTED: CLIP-associating protein isoform X3 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 A1A5G0 890 1.2e-93 CLIP-associating protein 1 OS=Xenopus tropicalis GN=clasp1 PE=1 SV=1 PF01602//PF01528//PF02985 Adaptin N terminal region//Herpesvirus glycoprotein M//HEAT repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0016020//GO:0030117 membrane//membrane coat -- -- Cluster-8309.4441 BP_3 2.00 0.32 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44410 BP_3 67.69 1.01 3530 642928007 XP_008200118.1 1706 3.5e-187 PREDICTED: solute carrier family 35, member F5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15289 SLC35F5 solute carrier family 35, member F5 http://www.genome.jp/dbget-bin/www_bget?ko:K15289 Q5R6J3 868 2.1e-91 Solute carrier family 35 member F5 OS=Pongo abelii GN=SLC35F5 PE=2 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG2765 Predicted membrane protein Cluster-8309.44412 BP_3 46.11 0.43 5402 189235691 XP_966538.2 1798 1.1e-197 PREDICTED: limbic system-associated membrane protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EHU7 696 2.8e-71 Endoplasmic reticulum-Golgi intermediate compartment protein 2 OS=Gecko japonicus GN=ERGIC2 PE=2 SV=1 PF11629//PF15333//PF00041//PF13895 C terminal SARAH domain of Mst1//TATA box-binding protein-associated factor 1D//Fibronectin type III domain//Immunoglobulin domain GO:0006355//GO:0016310//GO:0009069 regulation of transcription, DNA-templated//phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0004674 protein binding//protein serine/threonine kinase activity GO:0005668//GO:0005634 RNA polymerase transcription factor SL1 complex//nucleus KOG2667 COPII vesicle protein Cluster-8309.44413 BP_3 83.84 1.13 3870 642920297 XP_975609.3 526 2.6e-50 PREDICTED: interferon regulatory factor 2-binding protein 2 isoform X1 [Tribolium castaneum] 642920300 XM_008194067.1 94 9.78171e-39 PREDICTED: Tribolium castaneum interferon regulatory factor 2-binding protein 2 (LOC664517), transcript variant X3, mRNA -- -- -- -- Q7Z5L9 405 1.1e-37 Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens GN=IRF2BP2 PE=1 SV=2 PF00097//PF02778 Zinc finger, C3HC4 type (RING finger)//tRNA intron endonuclease, N-terminal domain GO:0006388//GO:0051252 tRNA splicing, via endonucleolytic cleavage and ligation//regulation of RNA metabolic process GO:0000213//GO:0046872 tRNA-intron endonuclease activity//metal ion binding GO:0000214 tRNA-intron endonuclease complex KOG3579 Predicted E3 ubiquitin ligase Cluster-8309.44414 BP_3 142.55 1.36 5346 189235691 XP_966538.2 1798 1.1e-197 PREDICTED: limbic system-associated membrane protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EHU7 696 2.8e-71 Endoplasmic reticulum-Golgi intermediate compartment protein 2 OS=Gecko japonicus GN=ERGIC2 PE=2 SV=1 PF13895//PF00041//PF15333//PF11629 Immunoglobulin domain//Fibronectin type III domain//TATA box-binding protein-associated factor 1D//C terminal SARAH domain of Mst1 GO:0016310//GO:0009069//GO:0006355 phosphorylation//serine family amino acid metabolic process//regulation of transcription, DNA-templated GO:0005515//GO:0004674 protein binding//protein serine/threonine kinase activity GO:0005668//GO:0005634 RNA polymerase transcription factor SL1 complex//nucleus KOG2667 COPII vesicle protein Cluster-8309.44416 BP_3 1245.34 14.52 4425 189235691 XP_966538.2 1798 9.3e-198 PREDICTED: limbic system-associated membrane protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EHU7 696 2.3e-71 Endoplasmic reticulum-Golgi intermediate compartment protein 2 OS=Gecko japonicus GN=ERGIC2 PE=2 SV=1 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- KOG2667 COPII vesicle protein Cluster-8309.44417 BP_3 262.77 2.35 5687 270007804 EFA04252.1 2632 2.3e-294 hypothetical protein TcasGA2_TC014542 [Tribolium castaneum] 831223259 XM_012804206.1 235 5.9899e-117 PREDICTED: Otolemur garnettii RAN binding protein 9 (RANBP9), mRNA -- -- -- -- Q96S59 1739 3.4e-192 Ran-binding protein 9 OS=Homo sapiens GN=RANBP9 PE=1 SV=1 PF06005//PF00622//PF17122//PF07989//PF08513//PF04977 Protein of unknown function (DUF904)//SPRY domain//Zinc-finger//Centrosomin N-terminal motif 1//LisH//Septum formation initiator GO:0000917//GO:0043093//GO:0007049 barrier septum assembly//FtsZ-dependent cytokinesis//cell cycle GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005737//GO:0005815 cytoplasm//microtubule organizing center KOG1477 SPRY domain-containing proteins Cluster-8309.44418 BP_3 565.00 7.74 3808 270010332 EFA06780.1 1053 2.0e-111 hypothetical protein TcasGA2_TC009716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44419 BP_3 81.18 0.62 6640 270003174 EEZ99621.1 1609 1.2e-175 hypothetical protein TcasGA2_TC002139 [Tribolium castaneum] -- -- -- -- -- K14832 MAK21, NOC1, CEBPZ ribosome biogenesis protein MAK21 http://www.genome.jp/dbget-bin/www_bget?ko:K14832 Q03701 977 9.1e-104 CCAAT/enhancer-binding protein zeta OS=Homo sapiens GN=CEBPZ PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein Cluster-8309.44421 BP_3 658.00 48.03 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44423 BP_3 511.61 32.74 1045 642931033 XP_008196186.1 410 1.9e-37 PREDICTED: uncharacterized protein LOC103313792 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05497 Destabilase GO:0005975 carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-8309.44424 BP_3 641.98 7.76 4279 478253821 ENN74113.1 4520 0.0e+00 hypothetical protein YQE_09086, partial [Dendroctonus ponderosae]>gi|546684626|gb|ERL94243.1| hypothetical protein D910_11524 [Dendroctonus ponderosae] 817219709 XM_012430138.1 107 6.42355e-46 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 3311 0.0e+00 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF16656//PF13895//PF01618//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//MotA/TolQ/ExbB proton channel family//Fibronectin type III domain GO:0006810//GO:0019497//GO:0006771//GO:0015031 transport//hexachlorocyclohexane metabolic process//riboflavin metabolic process//protein transport GO:0005515//GO:0003993//GO:0008565//GO:0046872 protein binding//acid phosphatase activity//protein transporter activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.44425 BP_3 49.48 4.15 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44427 BP_3 941.90 12.26 3994 646714577 KDR18490.1 1909 1.1e-210 Cytospin-A [Zootermopsis nevadensis] 817187826 XM_012433045.1 176 2.63445e-84 PREDICTED: Orussus abietinus cytospin-A (LOC105704102), transcript variant X5, mRNA -- -- -- -- Q2KN98 542 1.5e-53 Cytospin-A OS=Mus musculus GN=Specc1l PE=1 SV=1 PF07926//PF03920//PF00307//PF06667 TPR/MLP1/MLP2-like protein//Groucho/TLE N-terminal Q-rich domain//Calponin homology (CH) domain//Phage shock protein B GO:0006355//GO:0006606//GO:0009271 regulation of transcription, DNA-templated//protein import into nucleus//phage shock GO:0005515 protein binding -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.44429 BP_3 2816.89 15.26 9191 270002460 EEZ98907.1 4938 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1803 2.1e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF07649//PF01363//PF02148 C1-like domain//FYVE zinc finger//Zn-finger in ubiquitin-hydrolases and other protein GO:0055114 oxidation-reduction process GO:0047134//GO:0046872//GO:0008270 protein-disulfide reductase activity//metal ion binding//zinc ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.44430 BP_3 411.64 4.03 5211 642912265 XP_008200629.1 1906 3.3e-210 PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912267|ref|XP_008200630.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912269|ref|XP_008200631.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q6IRB8 281 3.6e-23 Lysine-specific demethylase 3A-A OS=Xenopus laevis GN=kdm3a-a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44431 BP_3 1541.67 6.29 12107 91092426 XP_968165.1 6155 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC1 [Tribolium castaneum]>gi|270004743|gb|EFA01191.1| hypothetical protein TcasGA2_TC010518 [Tribolium castaneum] 617460781 XM_007571860.1 414 0 PREDICTED: Poecilia formosa ATP-binding cassette, sub-family E (OABP), member 1 (abce1), mRNA K03018 RPC1, POLR3A DNA-directed RNA polymerase III subunit RPC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03018 Q5ZL98 4386 0.0e+00 DNA-directed RNA polymerase III subunit RPC1 OS=Gallus gallus GN=POLR3A PE=2 SV=1 PF04997//PF02367//PF00623//PF04998//PF00931//PF13304//PF07728//PF08477//PF05000//PF04983//PF00004//PF03193//PF00005//PF00910//PF07851//PF07352//PF00448//PF01920//PF06810 RNA polymerase Rpb1, domain 1//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 5//NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 3//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//RNA helicase//TMPIT-like protein//Bacteriophage Mu Gam like protein//SRP54-type protein, GTPase domain//Prefoldin subunit//Phage minor structural protein GP20 GO:0007264//GO:0002949//GO:0006206//GO:0006144//GO:0042262//GO:0006351//GO:0006457//GO:0006614 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//DNA protection//transcription, DNA-templated//protein folding//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0003690//GO:0005525//GO:0032549//GO:0043531//GO:0003723//GO:0003677//GO:0008270//GO:0051082//GO:0016887//GO:0005198//GO:0003924//GO:0005524//GO:0003899 RNA helicase activity//double-stranded DNA binding//GTP binding//ribonucleoside binding//ADP binding//RNA binding//DNA binding//zinc ion binding//unfolded protein binding//ATPase activity//structural molecule activity//GTPase activity//ATP binding//DNA-directed RNA polymerase activity GO:0005634//GO:0016272//GO:0005730//GO:0016021 nucleus//prefoldin complex//nucleolus//integral component of membrane KOG0261 RNA polymerase III, large subunit Cluster-8309.44432 BP_3 16.25 0.38 2363 642910982 XP_008193494.1 803 1.2e-82 PREDICTED: uncharacterized protein LOC662081 isoform X1 [Tribolium castaneum] 642910981 XM_008195272.1 151 1.22393e-70 PREDICTED: Tribolium castaneum uncharacterized LOC662081 (LOC662081), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF15221 Lens epithelial cell protein LEP503 GO:0007275 multicellular organismal development -- -- -- -- -- -- Cluster-8309.44433 BP_3 52.61 0.86 3241 -- -- -- -- -- 462302786 APGK01050086.1 56 1.08811e-17 Dendroctonus ponderosae Seq01050096, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44440 BP_3 107.17 3.10 1957 642927980 XP_008195470.1 1064 5.3e-113 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08685 GON domain -- -- GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.44442 BP_3 533.80 11.53 2524 91084751 XP_971582.1 1374 7.8e-149 PREDICTED: scavenger receptor class B member 1-like [Tribolium castaneum]>gi|642925852|ref|XP_008190558.1| PREDICTED: scavenger receptor class B member 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 447 9.9e-43 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.44443 BP_3 299.62 2.14 7039 642922200 XP_008193059.1 1847 3.1e-203 PREDICTED: patronin isoform X6 [Tribolium castaneum] 645007691 XM_008218148.1 74 2.34308e-27 PREDICTED: Nasonia vitripennis patronin (LOC100118026), mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 794 1.6e-82 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF17095 Spectrin-binding region of Ca2+-Calmodulin GO:0031175 neuron projection development GO:0005516//GO:0030507 calmodulin binding//spectrin binding GO:0008091 spectrin KOG3654 Uncharacterized CH domain protein Cluster-8309.44444 BP_3 59.94 0.54 5688 642930270 XP_008196324.1 1161 8.8e-124 PREDICTED: uncharacterized protein LOC103313834 [Tribolium castaneum] 642930269 XM_008198102.1 181 6.25074e-87 PREDICTED: Tribolium castaneum uncharacterized LOC103313834 (LOC103313834), mRNA -- -- -- -- -- -- -- -- PF07557//PF10181 Shugoshin C terminus//GPI-GlcNAc transferase complex, PIG-H component GO:0045132 meiotic chromosome segregation GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0000775//GO:0005634 chromosome, centromeric region//nucleus -- -- Cluster-8309.44445 BP_3 58.00 0.33 8830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03554//PF03502 UL73 viral envelope glycoprotein//Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279//GO:0019031 cell outer membrane//viral envelope -- -- Cluster-8309.44448 BP_3 304.56 13.01 1420 91084625 XP_974579.1 1260 7.2e-136 PREDICTED: cullin-2 [Tribolium castaneum]>gi|270008911|gb|EFA05359.1| hypothetical protein TcasGA2_TC015524 [Tribolium castaneum] -- -- -- -- -- K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 696 7.5e-72 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2284 E3 ubiquitin ligase, Cullin 2 component Cluster-8309.44449 BP_3 154.26 1.60 4927 478254660 ENN74901.1 1230 7.6e-132 hypothetical protein YQE_08479, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12109//PF15953 CXCR4 Chemokine receptor N terminal//Putative propanediol utilisation -- -- GO:0005198//GO:0019955 structural molecule activity//cytokine binding -- -- -- -- Cluster-8309.44451 BP_3 9.00 13.38 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44452 BP_3 37.34 0.85 2413 546675819 ERL86931.1 1416 1.0e-153 hypothetical protein D910_04334, partial [Dendroctonus ponderosae] -- -- -- -- -- K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11147 1021 2.6e-109 Heat shock 70 kDa protein cognate 4 OS=Drosophila melanogaster GN=Hsc70-4 PE=1 SV=3 PF01968//PF06723 Hydantoinase/oxoprolinase//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0016787 hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.44455 BP_3 92.69 0.51 9104 642933690 XP_008197522.1 457 6.0e-42 PREDICTED: golgin subfamily A member 4-like [Tribolium castaneum]>gi|270012607|gb|EFA09055.1| hypothetical protein TcasGA2_TC006768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 229 6.8e-17 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF04048//PF02179 Sec8 exocyst complex component specific domain//BAG domain GO:0006904//GO:0015031 vesicle docking involved in exocytosis//protein transport GO:0051087 chaperone binding GO:0000145 exocyst -- -- Cluster-8309.44457 BP_3 220.00 5.39 2260 91080047 XP_972871.1 300 2.4e-24 PREDICTED: protein SREK1IP1 [Tribolium castaneum]>gi|270003217|gb|EEZ99664.1| hypothetical protein TcasGA2_TC002421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N9Q2 188 9.6e-13 Protein SREK1IP1 OS=Homo sapiens GN=SREK1IP1 PE=1 SV=1 PF06459//PF02724//PF05793//PF01080//PF02932 Ryanodine Receptor TM 4-6//CDC45-like protein//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Presenilin//Neurotransmitter-gated ion-channel transmembrane region GO:0006367//GO:0006811//GO:0006874//GO:0006270//GO:0006816//GO:0032968 transcription initiation from RNA polymerase II promoter//ion transport//cellular calcium ion homeostasis//DNA replication initiation//calcium ion transport//positive regulation of transcription elongation from RNA polymerase II promoter GO:0008270//GO:0003676//GO:0005219//GO:0004190//GO:0003677 zinc ion binding//nucleic acid binding//ryanodine-sensitive calcium-release channel activity//aspartic-type endopeptidase activity//DNA binding GO:0016020//GO:0005622//GO:0016021//GO:0005634 membrane//intracellular//integral component of membrane//nucleus KOG2985 Uncharacterized conserved protein Cluster-8309.44458 BP_3 99.41 0.74 6775 91076704 XP_972106.1 1365 2.3e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 7.2e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF13639//PF16685//PF10147//PF04142//PF08030//PF08449//PF13371//PF00892//PF00175//PF01297//PF00097//PF12678//PF14634 Ring finger domain//zinc RING finger of MSL2//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//Nucleotide-sugar transporter//Ferric reductase NAD binding domain//UAA transporter family//Tetratricopeptide repeat//EamA-like transporter family//Oxidoreductase NAD-binding domain//Zinc-uptake complex component A periplasmic//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain GO:0008643//GO:0030001//GO:0015780//GO:0007049//GO:0055114//GO:0055085 carbohydrate transport//metal ion transport//nucleotide-sugar transport//cell cycle//oxidation-reduction process//transmembrane transport GO:0046872//GO:0016491//GO:0005515//GO:0061630//GO:0005338//GO:0008270//GO:0005351 metal ion binding//oxidoreductase activity//protein binding//ubiquitin protein ligase activity//nucleotide-sugar transmembrane transporter activity//zinc ion binding//sugar:proton symporter activity GO:0016020//GO:0000139//GO:0005634//GO:0016021 membrane//Golgi membrane//nucleus//integral component of membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.44459 BP_3 124.32 1.36 4698 91076704 XP_972106.1 1365 1.6e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 5.0e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF08449//PF04142//PF13371//PF10147//PF13639//PF16685//PF12678//PF14634//PF01297//PF00097//PF00892//PF00175 UAA transporter family//Nucleotide-sugar transporter//Tetratricopeptide repeat//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//Ring finger domain//zinc RING finger of MSL2//RING-H2 zinc finger//zinc-RING finger domain//Zinc-uptake complex component A periplasmic//Zinc finger, C3HC4 type (RING finger)//EamA-like transporter family//Oxidoreductase NAD-binding domain GO:0055085//GO:0055114//GO:0007049//GO:0015780//GO:0030001//GO:0008643 transmembrane transport//oxidation-reduction process//cell cycle//nucleotide-sugar transport//metal ion transport//carbohydrate transport GO:0005351//GO:0008270//GO:0005338//GO:0061630//GO:0016491//GO:0005515//GO:0046872 sugar:proton symporter activity//zinc ion binding//nucleotide-sugar transmembrane transporter activity//ubiquitin protein ligase activity//oxidoreductase activity//protein binding//metal ion binding GO:0016021//GO:0005634//GO:0000139//GO:0016020 integral component of membrane//nucleus//Golgi membrane//membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.44461 BP_3 819.67 13.96 3121 646696804 KDR08844.1 4269 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component [Zootermopsis nevadensis] 642930974 XM_008197940.1 1005 0 PREDICTED: Tribolium castaneum 116 kDa U5 small nuclear ribonucleoprotein component (LOC661338), mRNA K12852 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component http://www.genome.jp/dbget-bin/www_bget?ko:K12852 Q5F3X4 3877 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component OS=Gallus gallus GN=EFTUD2 PE=2 SV=1 PF01926//PF08477//PF03144//PF00071//PF03764 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Elongation factor Tu domain 2//Ras family//Elongation factor G, domain IV GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0468 U5 snRNP-specific protein Cluster-8309.44463 BP_3 26.00 1.70 1029 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44467 BP_3 881.68 22.84 2152 91087131 XP_975238.1 1915 1.2e-211 PREDICTED: trifunctional enzyme subunit beta, mitochondrial [Tribolium castaneum]>gi|270009593|gb|EFA06041.1| hypothetical protein TcasGA2_TC008872 [Tribolium castaneum] -- -- -- -- -- K07509 HADHB acetyl-CoA acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07509 O46629 1508 7.9e-166 Trifunctional enzyme subunit beta, mitochondrial OS=Bos taurus GN=HADHB PE=2 SV=1 PF02803//PF00108//PF08545 Thiolase, C-terminal domain//Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0042967//GO:0006633//GO:0008152 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process//metabolic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.44470 BP_3 21.35 1.37 1042 817057502 XP_012269659.1 799 1.5e-82 PREDICTED: C-1-tetrahydrofolate synthase, cytoplasmic isoform X3 [Athalia rosae]>gi|817057504|ref|XP_012269660.1| PREDICTED: C-1-tetrahydrofolate synthase, cytoplasmic isoform X3 [Athalia rosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 O96553 728 1.1e-75 C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster GN=pug PE=1 SV=4 PF02882//PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0003824//GO:0004488 catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.44471 BP_3 591.48 17.61 1911 642935660 XP_008198104.1 481 2.1e-45 PREDICTED: cytochrome b reductase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08370 CYBRD1 cytochrome b reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08370 Q53TN4 208 3.9e-15 Cytochrome b reductase 1 OS=Homo sapiens GN=CYBRD1 PE=1 SV=1 PF01292//PF00033//PF03188 Prokaryotic cytochrome b561//Cytochrome b/b6/petB//Eukaryotic cytochrome b561 GO:0006118//GO:0022904 obsolete electron transport//respiratory electron transport chain GO:0009055 electron carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1619 Cytochrome b Cluster-8309.44472 BP_3 65.00 1.51 2373 313225548 CBY07022.1 161 3.3e-08 unnamed protein product [Oikopleura dioica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44473 BP_3 3111.98 46.62 3509 270013939 EFA10387.1 896 2.9e-93 hypothetical protein TcasGA2_TC012618 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 2.6e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF03188//PF01292 Eukaryotic cytochrome b561//Prokaryotic cytochrome b561 GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane KOG1619 Cytochrome b Cluster-8309.44475 BP_3 4.02 0.84 522 642932516 XP_008197146.1 366 1.2e-32 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B isoform X2 [Tribolium castaneum] 642932517 XM_008198925.1 102 4.44918e-44 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03043 323 4.9e-29 cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster GN=for PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.44477 BP_3 328.06 3.83 4417 91078312 XP_972704.1 4795 0.0e+00 PREDICTED: intraflagellar transport protein 122 homolog [Tribolium castaneum]>gi|270003955|gb|EFA00403.1| hypothetical protein TcasGA2_TC003254 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8WGF4 3404 0.0e+00 Intraflagellar transport protein 122 homolog OS=Xenopus tropicalis GN=ift122 PE=2 SV=1 PF00400//PF13176//PF01525//PF00637//PF04053 WD domain, G-beta repeat//Tetratricopeptide repeat//Rotavirus NS26//Region in Clathrin and VPS//Coatomer WD associated region GO:0019079//GO:0016192//GO:0006886 viral genome replication//vesicle-mediated transport//intracellular protein transport GO:0016887//GO:0000287//GO:0005515//GO:0005198 ATPase activity//magnesium ion binding//protein binding//structural molecule activity GO:0030117//GO:0030430 membrane coat//host cell cytoplasm KOG1538 Uncharacterized conserved protein WDR10, contains WD40 repeats Cluster-8309.44479 BP_3 1120.60 15.38 3803 642932911 XP_008197183.1 2530 1.1e-282 PREDICTED: ankyrin repeat domain-containing protein 13D isoform X1 [Tribolium castaneum]>gi|270012473|gb|EFA08921.1| hypothetical protein TcasGA2_TC006628 [Tribolium castaneum] 645004819 XM_001604621.3 84 3.48119e-33 PREDICTED: Nasonia vitripennis ankyrin repeat domain-containing protein 13D (LOC100121088), mRNA -- -- -- -- Q6PD24 1509 1.1e-165 Ankyrin repeat domain-containing protein 13D OS=Mus musculus GN=Ankrd13d PE=2 SV=2 PF15306//PF00023 LIN37//Ankyrin repeat GO:0007049 cell cycle GO:0005515 protein binding GO:0017053 transcriptional repressor complex KOG0522 Ankyrin repeat protein Cluster-8309.4448 BP_3 17.35 1.15 1017 642933131 XP_008197270.1 796 3.3e-82 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] 462326012 APGK01041603.1 84 9.08988e-34 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- Q8N4B1 379 3.1e-35 Sesquipedalian-1 OS=Homo sapiens GN=FAM109A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44480 BP_3 20.44 0.35 3079 524899886 XP_005106369.1 502 1.2e-47 PREDICTED: E3 ubiquitin-protein ligase mind-bomb-like isoform X1 [Aplysia californica] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 313 4.2e-27 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF14634//PF00097//PF00569//PF07663//PF15898//PF06701//PF13639 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc finger, ZZ type//Sorbitol phosphotransferase enzyme II C-terminus//cGMP-dependent protein kinase interacting domain//Mib_herc2//Ring finger domain GO:0009401//GO:0008643//GO:0016567 phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport//protein ubiquitination GO:0008270//GO:0008982//GO:0019901//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase binding//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0009357//GO:0016021 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger Cluster-8309.44483 BP_3 108.00 10.20 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44484 BP_3 2.30 0.55 494 642930472 XP_008196416.1 311 2.8e-26 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] -- -- -- -- -- K06238 COL6A collagen, type VI, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06238 Q868Z9 185 4.6e-13 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.44485 BP_3 104.26 1.76 3140 270016830 EFA13276.1 858 6.6e-89 hypothetical protein TcasGA2_TC016027 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 552 8.2e-55 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.44486 BP_3 650.89 14.38 2474 270003787 EFA00235.1 3339 0.0e+00 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 642915737 XM_008192562.1 745 0 PREDICTED: Tribolium castaneum kalirin (LOC656919), transcript variant X3, mRNA K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 Q0KL02 1708 5.8e-189 Triple functional domain protein OS=Mus musculus GN=Trio PE=1 SV=3 PF00435//PF11896//PF09589 Spectrin repeat//Domain of unknown function (DUF3416)//HrpA pilus formation protein GO:0009405//GO:0005975 pathogenesis//carbohydrate metabolic process GO:0004553//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//protein binding GO:0005615 extracellular space KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.44488 BP_3 1400.43 20.74 3547 189234051 XP_001809969.1 2712 7.7e-304 PREDICTED: solute carrier family 12 member 8 [Tribolium castaneum]>gi|270014477|gb|EFA10925.1| hypothetical protein TcasGA2_TC001752 [Tribolium castaneum] -- -- -- -- -- K14428 SLC12A8, CCC9 solute carrier family 12 (potassium/chloride transporters), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14428 Q6A4L1 1040 2.4e-111 Solute carrier family 12 member 8 OS=Xenopus laevis GN=slc12a8 PE=2 SV=1 PF02535//PF00324//PF13520 ZIP Zinc transporter//Amino acid permease//Amino acid permease GO:0030001//GO:0006865//GO:0055085//GO:0006810//GO:0003333 metal ion transport//amino acid transport//transmembrane transport//transport//amino acid transmembrane transport GO:0015171//GO:0046873 amino acid transmembrane transporter activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.44489 BP_3 204.57 2.67 3990 189234051 XP_001809969.1 2156 2.6e-239 PREDICTED: solute carrier family 12 member 8 [Tribolium castaneum]>gi|270014477|gb|EFA10925.1| hypothetical protein TcasGA2_TC001752 [Tribolium castaneum] -- -- -- -- -- K14428 SLC12A8, CCC9 solute carrier family 12 (potassium/chloride transporters), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14428 Q6A4L1 829 7.9e-87 Solute carrier family 12 member 8 OS=Xenopus laevis GN=slc12a8 PE=2 SV=1 PF00324//PF02535//PF13520 Amino acid permease//ZIP Zinc transporter//Amino acid permease GO:0030001//GO:0006865//GO:0055085//GO:0006810//GO:0003333 metal ion transport//amino acid transport//transmembrane transport//transport//amino acid transmembrane transport GO:0015171//GO:0046873 amino acid transmembrane transporter activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.44491 BP_3 708.21 8.76 4190 805759384 XP_012151679.1 1158 1.4e-123 PREDICTED: protein KRI1 homolog [Megachile rotundata] 820856991 XR_001112512.1 101 1.36129e-42 PREDICTED: Apis florea uncharacterized protein C1orf43 homolog (LOC100869278), transcript variant X3, misc_RNA K14786 KRI1 protein KRI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14786 Q9VTU0 542 1.6e-53 Protein KRI1 homolog OS=Drosophila melanogaster GN=CG5645 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2409 KRR1-interacting protein involved in 40S ribosome biogenesis Cluster-8309.44492 BP_3 65.61 0.86 3951 332372885 AEE61584.1 909 1.0e-94 unknown [Dendroctonus ponderosae]>gi|478252324|gb|ENN72750.1| hypothetical protein YQE_10555, partial [Dendroctonus ponderosae]>gi|546680657|gb|ERL90883.1| hypothetical protein D910_08228 [Dendroctonus ponderosae] 820856991 XR_001112512.1 101 1.28297e-42 PREDICTED: Apis florea uncharacterized protein C1orf43 homolog (LOC100869278), transcript variant X3, misc_RNA K14786 KRI1 protein KRI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14786 Q9VTU0 542 1.5e-53 Protein KRI1 homolog OS=Drosophila melanogaster GN=CG5645 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2409 KRR1-interacting protein involved in 40S ribosome biogenesis Cluster-8309.44494 BP_3 60.86 0.88 3620 642922580 XP_008193235.1 1425 1.4e-154 PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922582|ref|XP_008193236.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922584|ref|XP_008193237.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922586|ref|XP_008193238.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum] 642922589 XM_008195018.1 167 2.40245e-79 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X6, mRNA -- -- -- -- P55197 507 1.6e-49 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00130//PF05405//PF00628//PF12678 Phorbol esters/diacylglycerol binding domain (C1 domain)//Mitochondrial ATP synthase B chain precursor (ATP-synt_B)//PHD-finger//RING-H2 zinc finger GO:0035556//GO:0015992//GO:0015986 intracellular signal transduction//proton transport//ATP synthesis coupled proton transport GO:0005515//GO:0008270//GO:0015078 protein binding//zinc ion binding//hydrogen ion transmembrane transporter activity -- -- KOG0956 PHD finger protein AF10 Cluster-8309.44495 BP_3 1743.91 15.16 5837 91078256 XP_970842.1 4504 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 558207907 XM_006132981.1 93 5.32307e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2891 0.0e+00 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF03810//PF05773//PF05743 Importin-beta N-terminal domain//RWD domain//UEV domain GO:0015031//GO:0006886//GO:0006464 protein transport//intracellular protein transport//cellular protein modification process GO:0008536//GO:0005515//GO:0008565 Ran GTPase binding//protein binding//protein transporter activity GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.44496 BP_3 807.88 4.77 8458 820805550 AKG92766.1 2666 4.0e-298 Mlx interactor [Leptinotarsa decemlineata] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9HAP2 562 1.5e-55 MLX-interacting protein OS=Homo sapiens GN=MLXIP PE=1 SV=2 PF06005//PF00010//PF00595//PF13180 Protein of unknown function (DUF904)//Helix-loop-helix DNA-binding domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly GO:0046983//GO:0005515 protein dimerization activity//protein binding GO:0005737 cytoplasm KOG3582 Mlx interactors and related transcription factors Cluster-8309.44499 BP_3 626.79 15.60 2228 546675643 ERL86793.1 952 5.9e-100 hypothetical protein D910_04198 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TPQ9 231 9.7e-18 Arrestin domain-containing protein 3 OS=Mus musculus GN=Arrdc3 PE=2 SV=1 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.445 BP_3 6.00 0.62 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14249 Tocopherol cyclase -- -- GO:0009976 tocopherol cyclase activity -- -- -- -- Cluster-8309.44500 BP_3 213.50 2.64 4186 91094249 XP_968795.1 527 2.1e-50 PREDICTED: neurofilament heavy polypeptide [Tribolium castaneum]>gi|270016266|gb|EFA12712.1| hypothetical protein TcasGA2_TC002346 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54J55 130 9.4e-06 Myb-like protein X OS=Dictyostelium discoideum GN=mybX PE=3 SV=1 PF00378//PF16113//PF07213 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//DAP10 membrane protein GO:0008152//GO:0007165//GO:0014068//GO:0050776 metabolic process//signal transduction//positive regulation of phosphatidylinositol 3-kinase signaling//regulation of immune response GO:0043548//GO:0016836//GO:0003824//GO:0005102 phosphatidylinositol 3-kinase binding//hydro-lyase activity//catalytic activity//receptor binding GO:0016020 membrane -- -- Cluster-8309.44501 BP_3 2177.56 22.13 5034 270006638 EFA03086.1 1933 2.3e-213 hypothetical protein TcasGA2_TC012992 [Tribolium castaneum] 642925120 XM_008195954.1 531 0 PREDICTED: Tribolium castaneum YTH domain-containing family protein 3 (LOC659651), transcript variant X1, mRNA -- -- -- -- Q8BYK6 754 5.0e-78 YTH domain-containing family protein 3 OS=Mus musculus GN=Ythdf3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1901 Uncharacterized high-glucose-regulated protein Cluster-8309.44503 BP_3 494.06 6.39 4020 642923393 XP_008193730.1 1613 2.4e-176 PREDICTED: facilitated trehalose transporter Tret1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 457 1.1e-43 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF14634//PF12678//PF00097//PF11789//PF00083//PF07690//PF12861//PF01589//PF16685//PF13639 zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Sugar (and other) transporter//Major Facilitator Superfamily//Anaphase-promoting complex subunit 11 RING-H2 finger//Alphavirus E1 glycoprotein//zinc RING finger of MSL2//Ring finger domain GO:0016567//GO:0055085 protein ubiquitination//transmembrane transport GO:0004252//GO:0046872//GO:0008270//GO:0005515//GO:0061630//GO:0004842//GO:0022857 serine-type endopeptidase activity//metal ion binding//zinc ion binding//protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//transmembrane transporter activity GO:0005680//GO:0055036//GO:0019028//GO:0016021 anaphase-promoting complex//virion membrane//viral capsid//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.44504 BP_3 13.00 0.86 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44505 BP_3 277.24 3.56 4043 642923393 XP_008193730.1 1613 2.4e-176 PREDICTED: facilitated trehalose transporter Tret1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 457 1.1e-43 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF14634//PF12678//PF00097//PF11789//PF00083//PF07690//PF12861//PF01589//PF16685//PF13639 zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Sugar (and other) transporter//Major Facilitator Superfamily//Anaphase-promoting complex subunit 11 RING-H2 finger//Alphavirus E1 glycoprotein//zinc RING finger of MSL2//Ring finger domain GO:0055085//GO:0016567 transmembrane transport//protein ubiquitination GO:0008270//GO:0004252//GO:0046872//GO:0022857//GO:0005515//GO:0061630//GO:0004842 zinc ion binding//serine-type endopeptidase activity//metal ion binding//transmembrane transporter activity//protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity GO:0019028//GO:0016021//GO:0005680//GO:0055036 viral capsid//integral component of membrane//anaphase-promoting complex//virion membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.44507 BP_3 39.45 0.59 3521 328777746 XP_396692.3 823 8.5e-85 PREDICTED: roughened isoform X3 [Apis mellifera]>gi|340717290|ref|XP_003397118.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|350407287|ref|XP_003488045.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|380017382|ref|XP_003692636.1| PREDICTED: ras-like protein 3 [Apis florea]>gi|571537886|ref|XP_006558879.1| PREDICTED: roughened isoform X1 [Apis mellifera]>gi|571537889|ref|XP_006558880.1| PREDICTED: roughened isoform X2 [Apis mellifera]>gi|572258774|ref|XP_006607754.1| PREDICTED: ras-like protein 3-like isoform X1 [Apis dorsata]>gi|572258776|ref|XP_006607755.1| PREDICTED: ras-like protein 3-like isoform X2 [Apis dorsata]>gi|572258778|ref|XP_006607756.1| PREDICTED: ras-like protein 3-like isoform X3 [Apis dorsata]>gi|572258780|ref|XP_006607757.1| PREDICTED: ras-like protein 3-like isoform X4 [Apis dorsata]>gi|808126889|ref|XP_012166429.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126891|ref|XP_012166430.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126893|ref|XP_012166431.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|815906255|ref|XP_012238943.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906257|ref|XP_012238944.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906259|ref|XP_012238945.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|169668013|gb|ACA64426.1| RAS-like protein [Bombus ignitus] 642938605 XM_008201640.1 384 0 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 803 7.3e-84 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF01926//PF08477//PF03193//PF00025//PF00071//PF00268 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ras family//Ribonucleotide reductase, small chain GO:0006184//GO:0009186//GO:0007264//GO:0055114 obsolete GTP catabolic process//deoxyribonucleoside diphosphate metabolic process//small GTPase mediated signal transduction//oxidation-reduction process GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.44509 BP_3 1018.32 10.10 5152 91088913 XP_973082.1 2219 1.6e-246 PREDICTED: uncharacterized protein KIAA0556-like [Tribolium castaneum] 551546037 XM_005760895.1 51 1.04535e-14 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 1376 3.8e-150 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF01507//PF07685//PF00733//PF00764//PF08131//PF02568//PF07722 Phosphoadenosine phosphosulfate reductase family//CobB/CobQ-like glutamine amidotransferase domain//Asparagine synthase//Arginosuccinate synthase//Defensin-like peptide family//Thiamine biosynthesis protein (ThiI)//Peptidase C26 GO:0006522//GO:0008152//GO:0006529//GO:0006531//GO:0006560//GO:0009236//GO:0008033//GO:0006541//GO:0006526 alanine metabolic process//metabolic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process//cobalamin biosynthetic process//tRNA processing//glutamine metabolic process//arginine biosynthetic process GO:0004066//GO:0004810//GO:0003824//GO:0004055//GO:0005524//GO:0016787 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity//catalytic activity//argininosuccinate synthase activity//ATP binding//hydrolase activity GO:0005576 extracellular region KOG1622 GMP synthase Cluster-8309.44512 BP_3 156.95 1.52 5267 91088913 XP_973082.1 2046 1.9e-226 PREDICTED: uncharacterized protein KIAA0556-like [Tribolium castaneum] 551546037 XM_005760895.1 51 1.06885e-14 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 1376 3.9e-150 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF00733//PF07685//PF01507//PF02568//PF07722//PF00764//PF08131 Asparagine synthase//CobB/CobQ-like glutamine amidotransferase domain//Phosphoadenosine phosphosulfate reductase family//Thiamine biosynthesis protein (ThiI)//Peptidase C26//Arginosuccinate synthase//Defensin-like peptide family GO:0006522//GO:0006531//GO:0006560//GO:0008152//GO:0006529//GO:0009236//GO:0008033//GO:0006541//GO:0006526 alanine metabolic process//aspartate metabolic process//proline metabolic process//metabolic process//asparagine biosynthetic process//cobalamin biosynthetic process//tRNA processing//glutamine metabolic process//arginine biosynthetic process GO:0004066//GO:0004055//GO:0004810//GO:0003824//GO:0005524//GO:0016787 asparagine synthase (glutamine-hydrolyzing) activity//argininosuccinate synthase activity//tRNA adenylyltransferase activity//catalytic activity//ATP binding//hydrolase activity GO:0005576 extracellular region KOG1622 GMP synthase Cluster-8309.44514 BP_3 1085.98 53.23 1275 642931818 XP_008196746.1 1472 1.7e-160 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 P49915 1114 2.3e-120 GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens GN=GMPS PE=1 SV=1 PF00958 GMP synthase C terminal domain GO:0006536//GO:0006144//GO:0006164//GO:0006177 glutamate metabolic process//purine nucleobase metabolic process//purine nucleotide biosynthetic process//GMP biosynthetic process GO:0003922//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//ATP binding -- -- KOG1622 GMP synthase Cluster-8309.44517 BP_3 2721.43 16.04 8471 642911053 XP_008200620.1 8548 0.0e+00 PREDICTED: HEAT repeat-containing protein 5B isoform X2 [Tribolium castaneum] 549438536 KC282400.1 192 7.15748e-93 Leptinotarsa decemlineata clone 18-9298 disulfide-isomerase mRNA, partial cds -- -- -- -- Q9P2D3 5379 0.0e+00 HEAT repeat-containing protein 5B OS=Homo sapiens GN=HEATR5B PE=1 SV=2 PF02985//PF08785//PF00578//PF00085//PF00514 HEAT repeat//Ku C terminal domain like//AhpC/TSA family//Thioredoxin//Armadillo/beta-catenin-like repeat GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0016491//GO:0005515//GO:0016817 antioxidant activity//oxidoreductase activity//protein binding//hydrolase activity, acting on acid anhydrides -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.44519 BP_3 64.00 11.12 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4452 BP_3 117.55 3.85 1765 642936377 XP_971655.2 1589 6.4e-174 PREDICTED: S1 RNA-binding domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5C6 1100 1.3e-118 S1 RNA-binding domain-containing protein 1 OS=Homo sapiens GN=SRBD1 PE=1 SV=2 PF00575 S1 RNA binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG1856 Transcription elongation factor SPT6 Cluster-8309.44521 BP_3 4.00 0.51 673 478254979 ENN75212.1 181 4.5e-11 hypothetical protein YQE_08222, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44522 BP_3 92.58 1.80 2764 642924494 XP_008194318.1 1947 3.1e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 6.9e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.44524 BP_3 120.93 1.59 3967 642924494 XP_008194318.1 1947 4.4e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 9.9e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.44525 BP_3 296.96 2.20 6800 642937533 XP_008199086.1 1407 3.1e-152 PREDICTED: F-box only protein 9 [Tribolium castaneum] -- -- -- -- -- K10295 FBXO9 F-box protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10295 Q3ZBT2 828 1.8e-86 F-box only protein 9 OS=Bos taurus GN=FBXO9 PE=2 SV=2 PF03006//PF12937//PF13414//PF00303//PF13181//PF00515//PF00646 Haemolysin-III related//F-box-like//TPR repeat//Thymidylate synthase//Tetratricopeptide repeat//Tetratricopeptide repeat//F-box domain GO:0006231//GO:0006206 dTMP biosynthetic process//pyrimidine nucleobase metabolic process GO:0004799//GO:0005515 thymidylate synthase activity//protein binding GO:0016021 integral component of membrane KOG2997 F-box protein FBX9 Cluster-8309.44526 BP_3 366.94 2.72 6783 642937533 XP_008199086.1 1407 3.1e-152 PREDICTED: F-box only protein 9 [Tribolium castaneum] -- -- -- -- -- K10295 FBXO9 F-box protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10295 Q3ZBT2 828 1.8e-86 F-box only protein 9 OS=Bos taurus GN=FBXO9 PE=2 SV=2 PF00303//PF13414//PF03006//PF12937//PF00646//PF00515//PF13181 Thymidylate synthase//TPR repeat//Haemolysin-III related//F-box-like//F-box domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006206//GO:0006231 pyrimidine nucleobase metabolic process//dTMP biosynthetic process GO:0004799//GO:0005515 thymidylate synthase activity//protein binding GO:0016021 integral component of membrane KOG2997 F-box protein FBX9 Cluster-8309.44529 BP_3 173.65 4.87 2011 91089699 XP_974834.1 1210 6.4e-130 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum]>gi|270011321|gb|EFA07769.1| hypothetical protein TcasGA2_TC005323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 173 4.7e-11 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF13414//PF00856 TPR repeat//SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.4453 BP_3 54.00 4.25 904 642936377 XP_971655.2 504 2.1e-48 PREDICTED: S1 RNA-binding domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q497V5 379 2.7e-35 S1 RNA-binding domain-containing protein 1 OS=Mus musculus GN=Srbd1 PE=2 SV=2 PF14641 Helix-turn-helix DNA-binding domain of SPT6 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.44531 BP_3 71.12 1.12 3357 478250976 ENN71460.1 1093 4.0e-116 hypothetical protein YQE_11877, partial [Dendroctonus ponderosae]>gi|546682655|gb|ERL92567.1| hypothetical protein D910_09880 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P46941 324 2.4e-28 WW domain-containing protein tag-325 OS=Caenorhabditis elegans GN=tag-325 PE=3 SV=1 PF00620//PF02749 RhoGAP domain//Quinolinate phosphoribosyl transferase, N-terminal domain GO:0007165 signal transduction GO:0016763 transferase activity, transferring pentosyl groups -- -- KOG1450 Predicted Rho GTPase-activating protein Cluster-8309.44534 BP_3 2484.83 71.96 1956 642930397 XP_008196382.1 1526 1.4e-166 PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930399|ref|XP_008196383.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930401|ref|XP_008196384.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|270010720|gb|EFA07168.1| hypothetical protein TcasGA2_TC010167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7JUY7 636 9.3e-65 PTB domain-containing adapter protein ced-6 OS=Drosophila melanogaster GN=ced-6 PE=1 SV=1 PF00640//PF08416//PF14719 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG3536 Adaptor protein CED-6, contains PTB domain Cluster-8309.44536 BP_3 30.73 0.47 3456 642926809 XP_008195022.1 416 1.3e-37 PREDICTED: zinc finger protein 64 homolog, isoforms 3 and 4-like [Tribolium castaneum]>gi|270009173|gb|EFA05621.1| hypothetical protein TcasGA2_TC015829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PVG3 262 3.8e-21 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF07776//PF01235//PF04120//PF01309//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Sodium:alanine symporter family//Low affinity iron permease//Equine arteritis virus small envelope glycoprotein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0055085//GO:0015846//GO:0032328//GO:0015804//GO:0006814 transmembrane transport//polyamine transport//alanine transport//neutral amino acid transport//sodium ion transport GO:0046872//GO:0015655//GO:0008270 metal ion binding//alanine:sodium symporter activity//zinc ion binding GO:0019031//GO:0005634//GO:0016020 viral envelope//nucleus//membrane -- -- Cluster-8309.44537 BP_3 114.97 1.52 3936 642921067 XP_008192678.1 931 2.8e-97 PREDICTED: LIM domain only protein 3-like isoform X3 [Tribolium castaneum] 642921066 XM_008194456.1 286 1.84338e-145 PREDICTED: Tribolium castaneum LIM domain only protein 3-like (LOC663863), transcript variant X3, mRNA -- -- -- -- Q99MB5 570 8.4e-57 LIM domain only protein 3 OS=Rattus norvegicus GN=Lmo3 PE=2 SV=2 PF06112//PF00412 Gammaherpesvirus capsid protein//LIM domain -- -- GO:0008270 zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.44538 BP_3 2.08 0.93 398 270009921 EFA06369.1 246 7.7e-19 hypothetical protein TcasGA2_TC009245 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44542 BP_3 668.99 25.81 1541 478258647 ENN78697.1 1059 1.6e-112 hypothetical protein YQE_04869, partial [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24046 790 1.0e-82 Sodium/potassium-transporting ATPase subunit beta-1 OS=Drosophila melanogaster GN=nrv1 PE=1 SV=2 PF03598//PF00287 CO dehydrogenase/acetyl-CoA synthase complex beta subunit//Sodium / potassium ATPase beta chain GO:0006084//GO:0006814//GO:0015947//GO:0006813 acetyl-CoA metabolic process//sodium ion transport//methane metabolic process//potassium ion transport GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity GO:0005890 sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.44543 BP_3 57.40 0.36 8046 133722006 ABO37162.1 1645 9.3e-180 3-hydroxy-3-methylglutaryl-CoA reductase [Chrysomela populi] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 1112 2.4e-119 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF02932//PF02460//PF00628//PF00643//PF14634//PF00283//PF17123//PF13639//PF00368 Neurotransmitter-gated ion-channel transmembrane region//Patched family//PHD-finger//B-box zinc finger//zinc-RING finger domain//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//RING-like zinc finger//Ring finger domain//Hydroxymethylglutaryl-coenzyme A reductase GO:0055114//GO:0006694//GO:0006811//GO:0015936//GO:0007165//GO:0015979 oxidation-reduction process//steroid biosynthetic process//ion transport//coenzyme A metabolic process//signal transduction//photosynthesis GO:0008270//GO:0004420//GO:0005515//GO:0050662//GO:0008158 zinc ion binding//hydroxymethylglutaryl-CoA reductase (NADPH) activity//protein binding//coenzyme binding//hedgehog receptor activity GO:0005622//GO:0016020 intracellular//membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.44544 BP_3 658.68 5.62 5936 478257810 ENN77953.1 2106 2.4e-233 hypothetical protein YQE_05630, partial [Dendroctonus ponderosae] -- -- -- -- -- K14833 NOC2 nucleolar complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14833 Q9VIF0 1452 6.8e-159 Nucleolar complex protein 2 homolog OS=Drosophila melanogaster GN=CG9246 PE=1 SV=1 PF01292//PF00083//PF07690 Prokaryotic cytochrome b561//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006118 transmembrane transport//obsolete electron transport GO:0022857//GO:0009055 transmembrane transporter activity//electron carrier activity GO:0016021 integral component of membrane KOG2256 Predicted protein involved in nuclear export of pre-ribosomes Cluster-8309.44547 BP_3 191.11 1.77 5498 642939895 XP_008200229.1 2703 1.3e-302 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] 657546453 XM_008280188.1 50 4.01402e-14 PREDICTED: Stegastes partitus protein tyrosine phosphatase, non-receptor type 6 (ptpn6), mRNA K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q06124 1888 1.7e-209 Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens GN=PTPN11 PE=1 SV=2 PF00782//PF03832//PF00102 Dual specificity phosphatase, catalytic domain//WSK motif//Protein-tyrosine phosphatase GO:0006605//GO:0007165//GO:0006570//GO:0006470 protein targeting//signal transduction//tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes Cluster-8309.44548 BP_3 150.15 2.20 3587 121583752 NP_001073568.1 1122 1.8e-119 cuticular protein analogous to peritrophins 3-D2 precursor [Tribolium castaneum]>gi|119387892|gb|ABL73931.1| obstractor D [Tribolium castaneum]>gi|270002339|gb|EEZ98786.1| hypothetical protein TcasGA2_TC001350 [Tribolium castaneum] 815806463 XM_012368582.1 219 2.95118e-108 PREDICTED: Linepithema humile chondroitin proteoglycan-2-like (LOC105673158), mRNA -- -- -- -- Q86UB9 152 2.3e-08 Transmembrane protein 135 OS=Homo sapiens GN=TMEM135 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.44549 BP_3 113.00 1.29 4503 390362249 XP_001190749.2 1689 4.1e-185 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q505D1 908 6.2e-96 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF08513//PF07660//PF00023 Ankyrin repeat//LisH//Secretin and TonB N terminus short domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0019867 outer membrane -- -- Cluster-8309.44553 BP_3 252.18 1.70 7450 642920095 XP_008192202.1 1816 1.3e-199 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 8.2539e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.2e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.44554 BP_3 102.26 0.68 7492 642920095 XP_008192202.1 1816 1.3e-199 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 8.30066e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.2e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.44556 BP_3 55.31 0.39 7212 642926766 XP_008195005.1 4458 0.0e+00 PREDICTED: copper-transporting ATPase 1 isoform X1 [Tribolium castaneum] 827557043 XM_012694365.1 41 5.30867e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2576 3.8e-289 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF00403//PF01529//PF05138//PF00122 Heavy-metal-associated domain//DHHC palmitoyltransferase//Phenylacetic acid catabolic protein//E1-E2 ATPase GO:0010124//GO:0030001 phenylacetate catabolic process//metal ion transport GO:0046872//GO:0000166//GO:0008270 metal ion binding//nucleotide binding//zinc ion binding -- -- KOG0207 Cation transport ATPase Cluster-8309.44558 BP_3 130.16 3.30 2194 91076878 XP_974995.1 789 4.6e-81 PREDICTED: methionyl-tRNA formyltransferase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270001958|gb|EEZ98405.1| hypothetical protein TcasGA2_TC000873 [Tribolium castaneum] -- -- -- -- -- K00604 MTFMT, fmt methionyl-tRNA formyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00604 Q96DP5 572 2.8e-57 Methionyl-tRNA formyltransferase, mitochondrial OS=Homo sapiens GN=MTFMT PE=1 SV=2 PF04281//PF00551//PF02911 Mitochondrial import receptor subunit Tom22//Formyl transferase//Formyl transferase, C-terminal domain GO:0006886//GO:0009058//GO:0008152 intracellular protein transport//biosynthetic process//metabolic process GO:0003824//GO:0016742 catalytic activity//hydroxymethyl-, formyl- and related transferase activity GO:0005741 mitochondrial outer membrane KOG3082 Methionyl-tRNA formyltransferase Cluster-8309.44559 BP_3 443.52 14.02 1816 270006519 EFA02967.1 989 2.5e-104 hypothetical protein TcasGA2_TC030640 [Tribolium castaneum] -- -- -- -- -- K17725 ETHE1 sulfur dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K17725 Q9DCM0 746 1.5e-77 Persulfide dioxygenase ETHE1, mitochondrial OS=Mus musculus GN=Ethe1 PE=1 SV=2 PF15221 Lens epithelial cell protein LEP503 GO:0007275 multicellular organismal development -- -- -- -- KOG0813 Glyoxylase Cluster-8309.44560 BP_3 318.97 11.31 1651 642924888 XP_008194085.1 710 5.0e-72 PREDICTED: nibrin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5I2W8 420 8.8e-40 Nibrin OS=Danio rerio GN=nbn PE=2 SV=2 PF00498//PF15826 FHA domain//Bcl-2-binding component 3, p53 upregulated modulator of apoptosis GO:0090200//GO:0043065//GO:0097193 positive regulation of release of cytochrome c from mitochondria//positive regulation of apoptotic process//intrinsic apoptotic signaling pathway GO:0005515 protein binding GO:0005739 mitochondrion -- -- Cluster-8309.44561 BP_3 11.39 0.57 1250 189237846 XP_974719.2 1150 3.6e-123 PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|642924610|ref|XP_008194362.1| PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|270007960|gb|EFA04408.1| hypothetical protein TcasGA2_TC014707 [Tribolium castaneum] 642924609 XM_008196140.1 249 2.12545e-125 PREDICTED: Tribolium castaneum BTB/POZ domain-containing protein 6 (LOC663586), transcript variant X2, mRNA K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 F7ASZ0 344 4.3e-31 BTB/POZ domain-containing protein 3 OS=Callithrix jacchus GN=BTBD3 PE=2 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.44562 BP_3 639.54 19.97 1835 642924612 XP_008194363.1 2213 2.9e-246 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 374 2.1e-34 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.44564 BP_3 1055.86 44.09 1446 478259256 ENN79158.1 956 1.3e-100 hypothetical protein YQE_04344, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44565 BP_3 16.00 12.50 348 -- -- -- -- -- 462326012 APGK01041603.1 134 4.67309e-62 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44566 BP_3 54.34 0.41 6693 478260037 ENN79822.1 3053 0.0e+00 hypothetical protein YQE_03645, partial [Dendroctonus ponderosae] 642918140 XM_008193162.1 208 7.20425e-102 PREDICTED: Tribolium castaneum ATP-dependent DNA helicase Q4 (LOC655929), mRNA K10730 RECQL4 ATP-dependent DNA helicase Q4 http://www.genome.jp/dbget-bin/www_bget?ko:K10730 Q75NR7 1484 1.5e-162 ATP-dependent DNA helicase Q4 OS=Mus musculus GN=Recql4 PE=2 SV=2 PF00437//PF00735//PF00098//PF00158//PF00485//PF00270//PF00503//PF01580//PF03193//PF02367//PF06414 Type II/IV secretion system protein//Septin//Zinc knuckle//Sigma-54 interaction domain//Phosphoribulokinase / Uridine kinase family//DEAD/DEAH box helicase//G-protein alpha subunit//FtsK/SpoIIIE family//Protein of unknown function, DUF258//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin GO:0006355//GO:0007186//GO:0006810//GO:0007165//GO:0002949//GO:0008152 regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway//transport//signal transduction//tRNA threonylcarbamoyladenosine modification//metabolic process GO:0008270//GO:0000166//GO:0016301//GO:0019001//GO:0003924//GO:0008134//GO:0005524//GO:0031683//GO:0005525//GO:0003676//GO:0004871//GO:0003677 zinc ion binding//nucleotide binding//kinase activity//guanyl nucleotide binding//GTPase activity//transcription factor binding//ATP binding//G-protein beta/gamma-subunit complex binding//GTP binding//nucleic acid binding//signal transducer activity//DNA binding GO:0005667 transcription factor complex KOG0351 ATP-dependent DNA helicase Cluster-8309.44567 BP_3 496.05 2.90 8549 270012359 EFA08807.1 1895 1.0e-208 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.3e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF13639//PF00198//PF08783//PF00097//PF01588//PF00098//PF04564//PF14634//PF02817 Ring finger domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//DWNN domain//Zinc finger, C3HC4 type (RING finger)//Putative tRNA binding domain//Zinc knuckle//U-box domain//zinc-RING finger domain//e3 binding domain GO:0008152//GO:0016567 metabolic process//protein ubiquitination GO:0000049//GO:0005515//GO:0016746//GO:0004842//GO:0003676//GO:0008270//GO:0046872 tRNA binding//protein binding//transferase activity, transferring acyl groups//ubiquitin-protein transferase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.44568 BP_3 463.38 41.65 828 91083251 XP_974045.1 485 3.1e-46 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 780659103 XM_011694063.1 107 1.20281e-46 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 436 6.1e-42 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF00270 DEAD/DEAH box helicase -- -- GO:0008026//GO:0003676//GO:0005524 ATP-dependent helicase activity//nucleic acid binding//ATP binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.44569 BP_3 839.72 65.46 910 332376787 AEE63533.1 834 1.2e-86 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 617645164 XM_007532444.1 182 2.69531e-88 PREDICTED: Erinaceus europaeus DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A (DDX39A), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 800 4.2e-84 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.44570 BP_3 29.02 0.79 2070 91083251 XP_974045.1 697 2.0e-70 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 442626186 NM_001273171.1 169 1.05486e-80 Drosophila melanogaster helicase at 25E (Hel25E), transcript variant D, mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q63413 618 1.2e-62 Spliceosome RNA helicase Ddx39b OS=Rattus norvegicus GN=Ddx39b PE=2 SV=3 PF00128//PF02391//PF04851//PF00270//PF00765 Alpha amylase, catalytic domain//MoaE protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Autoinducer synthase GO:0005975//GO:0006777 carbohydrate metabolic process//Mo-molybdopterin cofactor biosynthetic process GO:0008026//GO:0003677//GO:0016787//GO:0016740//GO:0005524//GO:0003824//GO:0043169//GO:0003676 ATP-dependent helicase activity//DNA binding//hydrolase activity//transferase activity//ATP binding//catalytic activity//cation binding//nucleic acid binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.44574 BP_3 200.81 2.62 3991 642935662 XP_008198105.1 1005 7.5e-106 PREDICTED: cytochrome b reductase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 3.0e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF00033//PF03188//PF01292 Cytochrome b/b6/petB//Eukaryotic cytochrome b561//Prokaryotic cytochrome b561 GO:0006118//GO:0022904 obsolete electron transport//respiratory electron transport chain GO:0009055 electron carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1619 Cytochrome b Cluster-8309.44575 BP_3 704.08 8.94 4086 642935662 XP_008198105.1 1005 7.7e-106 PREDICTED: cytochrome b reductase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 3.0e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF03188//PF00033//PF01292 Eukaryotic cytochrome b561//Cytochrome b/b6/petB//Prokaryotic cytochrome b561 GO:0022904//GO:0006118 respiratory electron transport chain//obsolete electron transport GO:0009055 electron carrier activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1619 Cytochrome b Cluster-8309.44578 BP_3 17.79 1.08 1086 357611230 EHJ67381.1 181 7.3e-11 hypothetical protein KGM_13834 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44580 BP_3 452.06 4.19 5494 642930886 XP_008196126.1 327 4.3e-27 PREDICTED: myb-like protein X isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 197 2.1e-13 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44582 BP_3 76.44 0.90 4392 478262463 ENN81134.1 1181 3.2e-126 hypothetical protein YQE_02502, partial [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q06AU5 724 1.3e-74 Ras-related protein Rab-32 OS=Sus scrofa GN=RAB32 PE=2 SV=1 PF02367//PF04670//PF10662//PF00071//PF01926//PF08477//PF15168//PF00025 Threonylcarbamoyl adenosine biosynthesis protein TsaE//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Triple QxxK/R motif-containing protein family//ADP-ribosylation factor family GO:0007264//GO:0006576//GO:0002949 small GTPase mediated signal transduction//cellular biogenic amine metabolic process//tRNA threonylcarbamoyladenosine modification GO:0005525//GO:0005524 GTP binding//ATP binding GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.44583 BP_3 92.68 1.04 4580 189236906 XP_001809986.1 1625 1.1e-177 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 781 3.4e-81 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF00140//PF01529//PF13606//PF00023 Sigma-70 factor, region 1.2//DHHC palmitoyltransferase//Ankyrin repeat//Ankyrin repeat GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0008270//GO:0016987//GO:0003700//GO:0046872//GO:0003677//GO:0005515 zinc ion binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//DNA binding//protein binding GO:0005667 transcription factor complex KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.44584 BP_3 590.77 7.35 4167 189239223 XP_973572.2 678 6.5e-68 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 7.75384e-75 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44586 BP_3 66.46 0.98 3569 270006797 EFA03245.1 212 6.1e-14 hypothetical protein TcasGA2_TC013178 [Tribolium castaneum] -- -- -- -- -- K13171 SRRM1, SRM160 serine/arginine repetitive matrix protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13171 Q52KI8 169 2.4e-10 Serine/arginine repetitive matrix protein 1 OS=Mus musculus GN=Srrm1 PE=1 SV=2 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2146 Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) Cluster-8309.44588 BP_3 86.75 1.28 3563 91089227 XP_968078.1 1676 1.1e-183 PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum]>gi|642932923|ref|XP_008197189.1| PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 699 8.4e-72 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF00498//PF12920 FHA domain//TcdA/TcdB pore forming domain GO:0009405 pathogenesis GO:0005515 protein binding -- -- KOG3872 FOG: FHA domain Cluster-8309.44589 BP_3 1120.50 16.79 3509 91089227 XP_968078.1 1676 1.0e-183 PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum]>gi|642932923|ref|XP_008197189.1| PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 699 8.3e-72 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF00498//PF12920 FHA domain//TcdA/TcdB pore forming domain GO:0009405 pathogenesis GO:0005515 protein binding -- -- KOG3872 FOG: FHA domain Cluster-8309.44591 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44592 BP_3 88.77 1.16 3987 642910866 XP_001813884.2 3464 0.0e+00 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1321 7.1e-144 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF08123//PF02390//PF00103 Histone methylation protein DOT1//Putative methyltransferase//Somatotropin hormone family GO:0007165//GO:0009451//GO:0006479//GO:0006554//GO:0008033//GO:0006400 signal transduction//RNA modification//protein methylation//lysine catabolic process//tRNA processing//tRNA modification GO:0018024//GO:0005179//GO:0008176 histone-lysine N-methyltransferase activity//hormone activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.44595 BP_3 41.83 0.36 5904 642930905 XP_008196134.1 432 3.1e-39 PREDICTED: TRAF-type zinc finger domain-containing protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01001 Hepatitis C virus non-structural protein NS4b GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0017111//GO:0004252//GO:0004197//GO:0003968 nucleoside-triphosphatase activity//serine-type endopeptidase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.44596 BP_3 98.12 0.81 6098 642920225 XP_008192255.1 659 1.5e-65 PREDICTED: receptor-type tyrosine-protein phosphatase mu-like [Tribolium castaneum] -- -- -- -- -- K18035 PTPRO receptor-type tyrosine-protein phosphatase O http://www.genome.jp/dbget-bin/www_bget?ko:K18035 Q16827 318 2.2e-27 Receptor-type tyrosine-protein phosphatase O OS=Homo sapiens GN=PTPRO PE=1 SV=2 PF00102//PF00041 Protein-tyrosine phosphatase//Fibronectin type III domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0005515//GO:0004725 protein binding//protein tyrosine phosphatase activity -- -- KOG0791 Protein tyrosine phosphatase, contains fn3 domain Cluster-8309.44601 BP_3 178.00 0.96 9243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12422 Condensin II non structural maintenance of chromosomes subunit -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.44602 BP_3 527.22 5.88 4617 255918127 NP_001157610.1 1687 7.2e-185 tramtrack [Tribolium castaneum]>gi|642921896|ref|XP_008192935.1| PREDICTED: tramtrack isoform X1 [Tribolium castaneum] 751794272 XR_852685.1 49 1.21084e-13 PREDICTED: Bactrocera dorsalis polyhomeotic-proximal chromatin protein-like (LOC105228656), transcript variant X5, misc_RNA K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 578 1.2e-57 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF02178//PF00096//PF13465//PF13912//PF00651 AT hook motif//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BTB/POZ domain -- -- GO:0005515//GO:0046872//GO:0003677 protein binding//metal ion binding//DNA binding -- -- -- -- Cluster-8309.44603 BP_3 30.53 0.36 4388 255918127 NP_001157610.1 1687 6.9e-185 tramtrack [Tribolium castaneum]>gi|642921896|ref|XP_008192935.1| PREDICTED: tramtrack isoform X1 [Tribolium castaneum] 751794272 XR_852685.1 49 1.15031e-13 PREDICTED: Bactrocera dorsalis polyhomeotic-proximal chromatin protein-like (LOC105228656), transcript variant X5, misc_RNA K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 578 1.1e-57 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF02178//PF13465//PF00096//PF13912//PF00651 AT hook motif//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BTB/POZ domain -- -- GO:0003677//GO:0005515//GO:0046872 DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.44604 BP_3 369.52 9.06 2258 270009876 EFA06324.1 1586 1.8e-173 hypothetical protein TcasGA2_TC009195 [Tribolium castaneum] 704338400 XM_010176089.1 39 2.12897e-08 PREDICTED: Caprimulgus carolinensis salvador family WW domain containing protein 1 (SAV1), mRNA K16686 SAV1, Sav scaffold protein salvador http://www.genome.jp/dbget-bin/www_bget?ko:K16686 Q9H4B6 559 9.1e-56 Protein salvador homolog 1 OS=Homo sapiens GN=SAV1 PE=1 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.44607 BP_3 65.59 3.77 1131 642921248 XP_969543.2 563 3.8e-55 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 Q7KQM6 245 1.2e-19 PERQ amino acid-rich with GYF domain-containing protein CG11148 OS=Drosophila melanogaster GN=CG11148 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44608 BP_3 40.00 1.60 1499 478250837 ENN71327.1 180 1.3e-10 hypothetical protein YQE_11987, partial [Dendroctonus ponderosae] 642921251 XM_008194562.1 101 4.79912e-43 PREDICTED: Tribolium castaneum PERQ amino acid-rich with GYF domain-containing protein 2 (LOC658036), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF12297 Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- -- -- -- -- Cluster-8309.44610 BP_3 157.49 3.40 2523 642933298 XP_008197360.1 655 1.8e-65 PREDICTED: LOW QUALITY PROTEIN: mucin-17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44611 BP_3 21.39 0.77 1625 546676387 ERL87409.1 298 2.9e-24 hypothetical protein D910_04804 [Dendroctonus ponderosae] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 P08074 219 1.8e-16 Carbonyl reductase [NADPH] 2 OS=Mus musculus GN=Cbr2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.44614 BP_3 478.61 8.14 3126 642921224 XP_008192769.1 1615 1.1e-176 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921235 XM_008194553.1 303 5.17918e-155 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 651 2.7e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF14604//PF00023//PF00018//PF13606 Variant SH3 domain//Ankyrin repeat//SH3 domain//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.44616 BP_3 610.26 6.26 4993 642938298 XP_008192776.1 2305 1.7e-256 PREDICTED: late secretory pathway protein AVL9 homolog [Tribolium castaneum] 820839237 XM_012495150.1 168 9.23864e-80 PREDICTED: Apis florea late secretory pathway protein AVL9 homolog (LOC100871294), mRNA -- -- -- -- Q80U56 1230 3.2e-133 Late secretory pathway protein AVL9 homolog OS=Mus musculus GN=Avl9 PE=2 SV=2 PF01767 Birnavirus VP3 protein -- -- GO:0005198 structural molecule activity -- -- KOG3823 Uncharacterized conserved protein Cluster-8309.44618 BP_3 474.51 3.08 7715 260436903 NP_001159498.1 879 5.9e-91 U-box domain containing 5 [Tribolium castaneum] -- -- -- -- -- K10600 UBOX5, UIP5 U-box domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10600 Q925F4 318 2.8e-27 RING finger protein 37 OS=Mus musculus GN=Ubox5 PE=1 SV=2 PF04564//PF14634 U-box domain//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0005515//GO:0004842 zinc ion binding//protein binding//ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.44622 BP_3 14.04 0.74 1207 270011004 EFA07452.1 267 8.6e-21 serine protease P91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 145 4.9e-08 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF02022 Integrase Zinc binding domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.44625 BP_3 131.74 2.20 3176 546681102 ERL91258.1 1088 1.4e-115 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P34410 177 2.5e-11 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF01573 Bromovirus movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0044156 host cell junction -- -- Cluster-8309.44626 BP_3 154.54 6.85 1379 478260273 ENN80025.1 238 2.3e-17 hypothetical protein YQE_03502, partial [Dendroctonus ponderosae] -- -- -- -- -- K03424 tatD TatD DNase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03424 -- -- -- -- PF01026 TatD related DNase GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.44627 BP_3 186.25 1.13 8261 642919073 XP_008191722.1 1583 1.5e-172 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 1281 6.4e-139 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.44629 BP_3 247.46 1.55 7976 642919073 XP_008191722.1 1583 1.4e-172 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 1281 6.1e-139 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.4463 BP_3 1.00 0.32 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44630 BP_3 241.16 3.66 3469 817051906 XP_012253468.1 1791 4.7e-197 PREDICTED: autophagy-related protein 16-1 isoform X2 [Athalia rosae] -- -- -- -- -- K17890 ATG16L autophagy-related protein 16, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K17890 Q676U5 920 1.9e-97 Autophagy-related protein 16-1 OS=Homo sapiens GN=ATG16L1 PE=1 SV=2 PF00105//PF00400//PF05837//PF08702 Zinc finger, C4 type (two domains)//WD domain, G-beta repeat//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family GO:0030168//GO:0006355//GO:0051258//GO:0051382//GO:0007165 platelet activation//regulation of transcription, DNA-templated//protein polymerization//kinetochore assembly//signal transduction GO:0003700//GO:0005102//GO:0008270//GO:0030674//GO:0043565//GO:0005515 transcription factor activity, sequence-specific DNA binding//receptor binding//zinc ion binding//protein binding, bridging//sequence-specific DNA binding//protein binding GO:0005577//GO:0000776//GO:0005667//GO:0005634 fibrinogen complex//kinetochore//transcription factor complex//nucleus KOG0288 WD40 repeat protein TipD Cluster-8309.44631 BP_3 97.50 2.03 2605 642921092 XP_008192688.1 1665 1.4e-182 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q9VDR1 538 2.9e-53 Mediator of RNA polymerase II transcription subunit 25 OS=Drosophila melanogaster GN=MED25 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44632 BP_3 165.00 2.37 3646 642928913 XP_971104.2 1611 3.7e-176 PREDICTED: FK506-binding protein 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05891 AdoMet dependent proline di-methyltransferase GO:0006480 N-terminal protein amino acid methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.44633 BP_3 45.22 0.83 2926 91083807 XP_973296.1 1994 1.2e-220 PREDICTED: organic cation transporter protein isoform X1 [Tribolium castaneum]>gi|270007927|gb|EFA04375.1| hypothetical protein TcasGA2_TC014673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 794 6.7e-83 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF03839//PF00083//PF07690 Translocation protein Sec62//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0015031 transmembrane transport//protein transport GO:0008565//GO:0022857 protein transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.44635 BP_3 1645.86 7.37 11053 642934936 XP_008195867.1 3128 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 205 5.54741e-100 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 548 8.4e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05225//PF05197 helix-turn-helix, Psq domain//TRIC channel GO:0015672//GO:0006812 monovalent inorganic cation transport//cation transport GO:0003677//GO:0005261 DNA binding//cation channel activity GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.44636 BP_3 2509.59 33.05 3952 478258615 ENN78665.1 504 9.3e-48 hypothetical protein YQE_04837, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08720 Influenza C hemagglutinin stalk GO:0007165//GO:0019064 signal transduction//fusion of virus membrane with host plasma membrane GO:0046789 host cell surface receptor binding GO:0009986//GO:0019031 cell surface//viral envelope -- -- Cluster-8309.44638 BP_3 363.07 2.21 8197 642920751 XP_008192546.1 1457 6.0e-158 PREDICTED: pre-mRNA cleavage complex 2 protein Pcf11 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 446 4.2e-42 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 PF08916 Phenylalanine zipper GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0004871 signal transducer activity -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.44639 BP_3 137.00 3.50 2180 780687510 XP_011698854.1 345 1.4e-29 PREDICTED: uncharacterized protein LOC105456480 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.44641 BP_3 457.56 12.38 2073 642929609 XP_008195902.1 2320 1.3e-258 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] 642929608 XM_008197680.1 221 1.30976e-109 PREDICTED: Tribolium castaneum FAS-associated factor 1 (LOC664346), mRNA -- -- -- -- Q9UNN5 1010 4.2e-108 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF09226//PF00240//PF00789 Restriction endonuclease HincII//Ubiquitin family//UBX domain GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0005515//GO:0003677//GO:0009036 protein binding//DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.44643 BP_3 176.04 1.27 6994 642910859 XP_008193438.1 1525 6.7e-166 PREDICTED: mitogen-activated protein kinase 14B-like [Tribolium castaneum] 749732005 XM_011139608.1 229 1.59574e-113 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1333 5.0e-145 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF13414//PF02434//PF06293//PF00069//PF01762//PF07714 TPR repeat//Fringe-like//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Galactosyltransferase//Protein tyrosine kinase GO:0006468//GO:0006486 protein phosphorylation//protein glycosylation GO:0005524//GO:0016757//GO:0005515//GO:0016773//GO:0008378//GO:0004672 ATP binding//transferase activity, transferring glycosyl groups//protein binding//phosphotransferase activity, alcohol group as acceptor//galactosyltransferase activity//protein kinase activity GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.44646 BP_3 729.83 49.95 996 91090021 XP_967356.1 957 6.9e-101 PREDICTED: peroxiredoxin-1 [Tribolium castaneum]>gi|270014285|gb|EFA10733.1| hypothetical protein TcasGA2_TC012328 [Tribolium castaneum] -- -- -- -- -- K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9Z0V6 678 6.4e-70 Thioredoxin-dependent peroxide reductase, mitochondrial OS=Rattus norvegicus GN=Prdx3 PE=1 SV=2 PF10417//PF00578//PF08534 C-terminal domain of 1-Cys peroxiredoxin//AhpC/TSA family//Redoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0051920//GO:0016491 antioxidant activity//peroxiredoxin activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.44648 BP_3 90.49 0.63 7239 189241670 XP_001807691.1 252 2.8e-18 PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum]>gi|642937361|ref|XP_008198805.1| PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 Q9M8S8 232 2.4e-17 Inositol-phosphate phosphatase OS=Arabidopsis thaliana GN=VTC4 PE=1 SV=1 PF03664//PF04159//PF02935//PF00459//PF05739 Glycosyl hydrolase family 62//NB glycoprotein//Cytochrome c oxidase subunit VIIc//Inositol monophosphatase family//SNARE domain GO:0009117//GO:0006123//GO:0046373//GO:0015992//GO:0046854//GO:0005975 nucleotide metabolic process//mitochondrial electron transport, cytochrome c to oxygen//L-arabinose metabolic process//proton transport//phosphatidylinositol phosphorylation//carbohydrate metabolic process GO:0046556//GO:0005515//GO:0004129 alpha-L-arabinofuranosidase activity//protein binding//cytochrome-c oxidase activity GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG2951 Inositol monophosphatase Cluster-8309.4465 BP_3 2.00 0.34 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44652 BP_3 34.28 1.32 1542 157115843 XP_001658309.1 1312 7.3e-142 AAEL001206-PA [Aedes aegypti]>gi|108883479|gb|EAT47704.1| AAEL001206-PA [Aedes aegypti] 820840943 XM_012483434.1 146 4.76839e-68 PREDICTED: Apis florea threonine--tRNA ligase, cytoplasmic-like (LOC100870854), mRNA K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q5XHY5 1126 1.1e-121 Threonine--tRNA ligase, cytoplasmic OS=Rattus norvegicus GN=Tars PE=2 SV=1 PF05149 Paraflagellar rod protein GO:0006566//GO:0006544//GO:0006435//GO:0006563 threonine metabolic process//glycine metabolic process//threonyl-tRNA aminoacylation//L-serine metabolic process GO:0005516//GO:0005524//GO:0004829 calmodulin binding//ATP binding//threonine-tRNA ligase activity GO:0005737//GO:0031514 cytoplasm//motile cilium KOG1637 Threonyl-tRNA synthetase Cluster-8309.44653 BP_3 22.07 0.44 2699 91087799 XP_967345.1 1807 5.1e-199 PREDICTED: threonine--tRNA ligase, cytoplasmic isoform X2 [Tribolium castaneum] 820840943 XM_012483434.1 146 8.42351e-68 PREDICTED: Apis florea threonine--tRNA ligase, cytoplasmic-like (LOC100870854), mRNA K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q3ZBV8 1584 1.5e-174 Threonine--tRNA ligase, cytoplasmic OS=Bos taurus GN=TARS PE=2 SV=1 PF07973//PF05149 Threonyl and Alanyl tRNA synthetase second additional domain//Paraflagellar rod protein GO:0043039 tRNA aminoacylation GO:0016876//GO:0005516//GO:0005524 ligase activity, forming aminoacyl-tRNA and related compounds//calmodulin binding//ATP binding GO:0031514 motile cilium KOG1637 Threonyl-tRNA synthetase Cluster-8309.44655 BP_3 25.95 0.61 2356 751223799 XP_011165208.1 233 1.5e-16 PREDICTED: uncharacterized protein LOC105199705 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44656 BP_3 25.37 0.53 2603 642927014 XP_001810799.2 529 7.7e-51 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9J0 162 1.1e-09 Peroxisomal leader peptide-processing protease OS=Homo sapiens GN=TYSND1 PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.44657 BP_3 181.55 2.43 3893 642922648 XP_008193260.1 2324 8.3e-259 PREDICTED: coiled-coil and C2 domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18260 CC2D1 coiled-coil and C2 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18260 Q29M42 1636 2.1e-180 Coiled-coil and C2 domain-containing protein 1-like OS=Drosophila pseudoobscura pseudoobscura GN=GA18377 PE=3 SV=2 PF00168//PF04097//PF00711 C2 domain//Nup93/Nic96//Beta defensin GO:0006952//GO:0006810 defense response//transport GO:0005515 protein binding GO:0005576//GO:0005643 extracellular region//nuclear pore KOG3837 Uncharacterized conserved protein, contains DM14 and C2 domains Cluster-8309.44658 BP_3 28.97 0.36 4191 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44662 BP_3 800.04 13.50 3149 478257994 ENN78132.1 1444 7.4e-157 hypothetical protein YQE_05286, partial [Dendroctonus ponderosae] 815908496 XM_003488754.2 48 2.95938e-13 PREDICTED: Bombus impatiens protein SEC13 homolog (LOC100746611), mRNA K14004 SEC13 protein transport protein SEC13 http://www.genome.jp/dbget-bin/www_bget?ko:K14004 P55735 1099 3.1e-118 Protein SEC13 homolog OS=Homo sapiens GN=SEC13 PE=1 SV=3 PF00400//PF00023//PF00097//PF13606//PF14634//PF13639//PF16685 WD domain, G-beta repeat//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//zinc-RING finger domain//Ring finger domain//zinc RING finger of MSL2 -- -- GO:0061630//GO:0005515//GO:0046872//GO:0008270 ubiquitin protein ligase activity//protein binding//metal ion binding//zinc ion binding -- -- KOG1332 Vesicle coat complex COPII, subunit SEC13 Cluster-8309.44664 BP_3 232.40 0.80 14305 91089729 XP_975072.1 3148 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|642933644|ref|XP_008197508.1| PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|270011308|gb|EFA07756.1| hypothetical protein TcasGA2_TC005310 [Tribolium castaneum] -- -- -- -- -- K05016 CLCN7 chloride channel 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05016 P51798 1839 2.2e-203 H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens GN=CLCN7 PE=1 SV=2 PF00170//PF00654//PF04111//PF15191//PF00769//PF15898//PF10473//PF05024//PF15036//PF13851//PF00709//PF03328//PF08702//PF02183//PF13326//PF09726//PF05837//PF07926 bZIP transcription factor//Voltage gated chloride channel//Autophagy protein Apg6//Synaptonemal complex central element protein 3//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//N-acetylglucosaminyl transferase component (Gpi1)//Interleukin 34//Growth-arrest specific micro-tubule binding//Adenylosuccinate synthetase//HpcH/HpaI aldolase/citrate lyase family//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Photosystem II Pbs27//Transmembrane protein//Centromere protein H (CENP-H)//TPR/MLP1/MLP2-like protein GO:0006144//GO:0006821//GO:0007130//GO:0040007//GO:0006506//GO:0006522//GO:0051258//GO:0006914//GO:0007165//GO:0007283//GO:0008284//GO:0006355//GO:0007131//GO:0006531//GO:0048870//GO:0008283//GO:0001934//GO:0010207//GO:0030168//GO:0006164//GO:0051382//GO:0055085//GO:0006606 purine nucleobase metabolic process//chloride transport//synaptonemal complex assembly//growth//GPI anchor biosynthetic process//alanine metabolic process//protein polymerization//autophagy//signal transduction//spermatogenesis//positive regulation of cell proliferation//regulation of transcription, DNA-templated//reciprocal meiotic recombination//aspartate metabolic process//cell motility//cell proliferation//positive regulation of protein phosphorylation//photosystem II assembly//platelet activation//purine nucleotide biosynthetic process//kinetochore assembly//transmembrane transport//protein import into nucleus GO:0017176//GO:0003824//GO:0042803//GO:0005525//GO:0043565//GO:0005247//GO:0019901//GO:0008092//GO:0030674//GO:0004019//GO:0008134//GO:0045502//GO:0003700//GO:0005157//GO:0005102 phosphatidylinositol N-acetylglucosaminyltransferase activity//catalytic activity//protein homodimerization activity//GTP binding//sequence-specific DNA binding//voltage-gated chloride channel activity//protein kinase binding//cytoskeletal protein binding//protein binding, bridging//adenylosuccinate synthase activity//transcription factor binding//dynein binding//transcription factor activity, sequence-specific DNA binding//macrophage colony-stimulating factor receptor binding//receptor binding GO:0016020//GO:0016021//GO:0031514//GO:0005737//GO:0005667//GO:0030286//GO:0000776//GO:0019898//GO:0005615//GO:0005577 membrane//integral component of membrane//motile cilium//cytoplasm//transcription factor complex//dynein complex//kinetochore//extrinsic component of membrane//extracellular space//fibrinogen complex KOG0474 Cl- channel CLC-7 and related proteins (CLC superfamily) Cluster-8309.44665 BP_3 15.49 0.55 1639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44666 BP_3 212.56 0.61 17197 91089729 XP_975072.1 3304 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|642933644|ref|XP_008197508.1| PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|270011308|gb|EFA07756.1| hypothetical protein TcasGA2_TC005310 [Tribolium castaneum] -- -- -- -- -- K05016 CLCN7 chloride channel 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05016 P51798 1914 5.3e-212 H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens GN=CLCN7 PE=1 SV=2 PF15191//PF00769//PF15898//PF10473//PF05024//PF00170//PF00654//PF04111//PF08702//PF02183//PF13326//PF09726//PF05837//PF07926//PF15036//PF03790//PF13851//PF00709//PF03328 Synaptonemal complex central element protein 3//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//N-acetylglucosaminyl transferase component (Gpi1)//bZIP transcription factor//Voltage gated chloride channel//Autophagy protein Apg6//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Photosystem II Pbs27//Transmembrane protein//Centromere protein H (CENP-H)//TPR/MLP1/MLP2-like protein//Interleukin 34//KNOX1 domain//Growth-arrest specific micro-tubule binding//Adenylosuccinate synthetase//HpcH/HpaI aldolase/citrate lyase family GO:0008283//GO:0048870//GO:0006531//GO:0001934//GO:0030168//GO:0010207//GO:0006164//GO:0055085//GO:0051382//GO:0006606//GO:0007130//GO:0006144//GO:0006821//GO:0040007//GO:0006522//GO:0006506//GO:0006914//GO:0051258//GO:0007165//GO:0007283//GO:0007131//GO:0006355//GO:0008284 cell proliferation//cell motility//aspartate metabolic process//positive regulation of protein phosphorylation//platelet activation//photosystem II assembly//purine nucleotide biosynthetic process//transmembrane transport//kinetochore assembly//protein import into nucleus//synaptonemal complex assembly//purine nucleobase metabolic process//chloride transport//growth//alanine metabolic process//GPI anchor biosynthetic process//autophagy//protein polymerization//signal transduction//spermatogenesis//reciprocal meiotic recombination//regulation of transcription, DNA-templated//positive regulation of cell proliferation GO:0008092//GO:0004019//GO:0030674//GO:0045502//GO:0008134//GO:0003700//GO:0005157//GO:0005102//GO:0003677//GO:0003824//GO:0017176//GO:0005525//GO:0042803//GO:0019901//GO:0005247//GO:0043565 cytoskeletal protein binding//adenylosuccinate synthase activity//protein binding, bridging//dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//macrophage colony-stimulating factor receptor binding//receptor binding//DNA binding//catalytic activity//phosphatidylinositol N-acetylglucosaminyltransferase activity//GTP binding//protein homodimerization activity//protein kinase binding//voltage-gated chloride channel activity//sequence-specific DNA binding GO:0005667//GO:0030286//GO:0000776//GO:0019898//GO:0005577//GO:0005615//GO:0005634//GO:0016020//GO:0031514//GO:0016021//GO:0005737 transcription factor complex//dynein complex//kinetochore//extrinsic component of membrane//fibrinogen complex//extracellular space//nucleus//membrane//motile cilium//integral component of membrane//cytoplasm KOG0474 Cl- channel CLC-7 and related proteins (CLC superfamily) Cluster-8309.44668 BP_3 38.22 0.72 2837 189235061 XP_001814285.1 1015 3.7e-107 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18749 289 2.3e-24 Oocyte zinc finger protein XlCOF6 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.44669 BP_3 96.74 0.91 5437 189240413 XP_969795.2 2244 2.2e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.13034e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.2e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00250//PF00498 Forkhead domain//FHA domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0005515//GO:0003700 sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44673 BP_3 417.26 9.16 2488 91089449 XP_967843.1 2043 2.0e-226 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 [Tribolium castaneum]>gi|270011408|gb|EFA07856.1| hypothetical protein TcasGA2_TC005426 [Tribolium castaneum] -- -- -- -- -- K14440 SMARCAL1, HARP SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14440 Q9VMX6 1255 2.0e-136 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Drosophila melanogaster GN=Marcal1 PE=1 SV=2 PF13949//PF04851//PF00176 ALIX V-shaped domain binding to HIV//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain GO:0016568 chromatin modification GO:0005515//GO:0003677//GO:0016787//GO:0004386//GO:0005524 protein binding//DNA binding//hydrolase activity//helicase activity//ATP binding GO:0005634 nucleus KOG1000 Chromatin remodeling protein HARP/SMARCAL1, DEAD-box superfamily Cluster-8309.44674 BP_3 132.34 2.97 2440 189238895 XP_966473.2 1135 3.9e-121 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 1.1e-27 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF13855//PF00128 Leucine rich repeat//Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169//GO:0005515 catalytic activity//cation binding//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.44676 BP_3 31.26 0.32 4971 642925814 XP_970128.3 570 2.6e-55 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 405 1.4e-37 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF01370//PF02737//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//short chain dehydrogenase GO:0006574//GO:0006550//GO:0008152//GO:0006633//GO:0018874//GO:0006568//GO:0006631//GO:0006552//GO:0006554//GO:0055114 valine catabolic process//isoleucine catabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//tryptophan metabolic process//fatty acid metabolic process//leucine catabolic process//lysine catabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491//GO:0003857 coenzyme binding//catalytic activity//oxidoreductase activity//3-hydroxyacyl-CoA dehydrogenase activity -- -- -- -- Cluster-8309.44680 BP_3 172.00 1295.37 251 795517215 XP_011712761.1 453 4.8e-43 PREDICTED: tubulin alpha-8 chain isoform X2 [Macaca nemestrina] 768423887 XM_011554570.1 186 4.00968e-91 PREDICTED: Plutella xylostella tubulin alpha chain (LOC105384350), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q32KN8 453 2.0e-44 Tubulin alpha-3 chain OS=Bos taurus GN=TUBA3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44683 BP_3 664.82 7.28 4693 189241196 XP_001810857.1 3678 0.0e+00 PREDICTED: zinc finger protein 91 [Tribolium castaneum]>gi|270013967|gb|EFA10415.1| hypothetical protein TcasGA2_TC012655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51523 616 4.7e-62 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13465//PF00096//PF02112//PF13912//PF01258 Zinc-finger double domain//Zinc finger, C2H2 type//cAMP phosphodiesterases class-II//C2H2-type zinc finger//Prokaryotic dksA/traR C4-type zinc finger GO:0006198 cAMP catabolic process GO:0046872//GO:0004115//GO:0008270//GO:0005488 metal ion binding//3',5'-cyclic-AMP phosphodiesterase activity//zinc ion binding//binding -- -- -- -- Cluster-8309.44684 BP_3 146.70 3.26 2461 91076358 XP_966407.1 1078 1.6e-114 PREDICTED: tubulin alpha-1A chain [Tribolium castaneum]>gi|270002884|gb|EEZ99331.1| tubulin alpha 1-like protein [Tribolium castaneum] 803322942 XM_012164297.1 329 1.43222e-169 PREDICTED: Ovis aries musimon tubulin alpha-3 chain (LOC101108295), transcript variant X3, mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q71U36 1070 5.6e-115 Tubulin alpha-1A chain OS=Homo sapiens GN=TUBA1A PE=1 SV=1 PF13912//PF00091//PF01766 C2H2-type zinc finger//Tubulin/FtsZ family, GTPase domain//Birnavirus VP2 protein GO:0006184//GO:0051258//GO:0007018 obsolete GTP catabolic process//protein polymerization//microtubule-based movement GO:0046872//GO:0005525//GO:0003924//GO:0005198 metal ion binding//GTP binding//GTPase activity//structural molecule activity GO:0005737//GO:0005874 cytoplasm//microtubule KOG1376 Alpha tubulin Cluster-8309.44685 BP_3 567.24 3.35 8465 642910377 XP_971554.2 7752 0.0e+00 PREDICTED: uncharacterized protein LOC660207 isoform X3 [Tribolium castaneum] 194747504 XM_001956156.1 230 5.37486e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q9CPW0 626 5.8e-63 Contactin-associated protein-like 2 OS=Mus musculus GN=Cntnap2 PE=1 SV=2 PF02432//PF10192//PF00014//PF00008 Fimbrial, major and minor subunit//Rhodopsin-like GPCR transmembrane domain//Kunitz/Bovine pancreatic trypsin inhibitor domain//EGF-like domain GO:0007155//GO:0007186//GO:0019236 cell adhesion//G-protein coupled receptor signaling pathway//response to pheromone GO:0004867//GO:0005515 serine-type endopeptidase inhibitor activity//protein binding GO:0009289 pilus -- -- Cluster-8309.44686 BP_3 36.14 0.84 2366 795020727 XP_011860021.1 875 5.3e-91 PREDICTED: transposable element P transposase isoform X2 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 310 7.2e-27 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44687 BP_3 7.21 0.42 1117 189235436 XP_001812776.1 823 2.7e-85 PREDICTED: protein twisted gastrulation [Tribolium castaneum]>gi|270004290|gb|EFA00738.1| hypothetical protein TcasGA2_TC003620 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54356 466 2.7e-45 Protein twisted gastrulation OS=Drosophila melanogaster GN=tsg PE=1 SV=1 PF03627 PapG carbohydrate binding domain GO:0007155 cell adhesion GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.44688 BP_3 21.02 2.17 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44690 BP_3 25.10 0.74 1917 91088681 XP_974930.1 1028 7.8e-109 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JFV8 482 6.6e-47 Synaptic vesicle membrane protein VAT-1 homolog OS=Danio rerio GN=vat1 PE=2 SV=1 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0005488 binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.44693 BP_3 7.72 0.46 1097 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03325//PF04568 Herpesvirus polymerase accessory protein//Mitochondrial ATPase inhibitor, IATP GO:0032780//GO:0019079//GO:0006260 negative regulation of ATPase activity//viral genome replication//DNA replication GO:0042030//GO:0030337 ATPase inhibitor activity//DNA polymerase processivity factor activity GO:0042575//GO:0005739 DNA polymerase complex//mitochondrion -- -- Cluster-8309.44695 BP_3 530.11 3.30 8025 91085649 XP_970922.1 6731 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum]>gi|270011037|gb|EFA07485.1| hypothetical protein TcasGA2_TC009375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R422 759 2.1e-78 CD109 antigen OS=Mus musculus GN=Cd109 PE=2 SV=1 PF00057//PF00432//PF00207//PF07678//PF02033//PF07677//PF01835 Low-density lipoprotein receptor domain class A//Prenyltransferase and squalene oxidase repeat//Alpha-2-macroglobulin family//A-macroglobulin complement component//Ribosome-binding factor A//A-macroglobulin receptor//MG2 domain GO:0006364//GO:0010951 rRNA processing//negative regulation of endopeptidase activity GO:0003824//GO:0004866//GO:0005515 catalytic activity//endopeptidase inhibitor activity//protein binding GO:0005576//GO:0005615 extracellular region//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.44696 BP_3 126.47 0.77 8201 91085649 XP_970922.1 3684 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum]>gi|270011037|gb|EFA07485.1| hypothetical protein TcasGA2_TC009375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6YHK3 723 3.2e-74 CD109 antigen OS=Homo sapiens GN=CD109 PE=1 SV=2 PF00432//PF00207//PF00057//PF07677//PF01835//PF07678//PF02033 Prenyltransferase and squalene oxidase repeat//Alpha-2-macroglobulin family//Low-density lipoprotein receptor domain class A//A-macroglobulin receptor//MG2 domain//A-macroglobulin complement component//Ribosome-binding factor A GO:0010951//GO:0006364 negative regulation of endopeptidase activity//rRNA processing GO:0005515//GO:0004866//GO:0003824 protein binding//endopeptidase inhibitor activity//catalytic activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.44699 BP_3 215.46 1.53 7096 642930298 XP_008196335.1 3056 0.0e+00 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1 [Tribolium castaneum] 642930305 XM_008198117.1 1318 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 Q9UL51 1577 2.6e-173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens GN=HCN2 PE=1 SV=3 PF00520//PF01676 Ion transport protein//Metalloenzyme superfamily GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0046872//GO:0003824//GO:0005216 metal ion binding//catalytic activity//ion channel activity GO:0016020 membrane -- -- Cluster-8309.447 BP_3 6.00 1.06 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44703 BP_3 88.00 10.57 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44704 BP_3 231.35 3.03 3966 642917429 XP_008191194.1 1648 2.1e-180 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1L258 1320 9.2e-144 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF01565//PF02913//PF08558 FAD binding domain//FAD linked oxidases, C-terminal domain//Telomere repeat binding factor (TRF) GO:0055114 oxidation-reduction process GO:0016491//GO:0042162//GO:0050660//GO:0003824//GO:0042803 oxidoreductase activity//telomeric DNA binding//flavin adenine dinucleotide binding//catalytic activity//protein homodimerization activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.44705 BP_3 15.75 0.70 1376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4471 BP_3 17.00 3.65 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07533 BRK domain -- -- GO:0016817//GO:0005515 hydrolase activity, acting on acid anhydrides//protein binding -- -- -- -- Cluster-8309.44710 BP_3 257.19 5.89 2395 91091932 XP_966409.1 3357 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 242021384 XM_002431080.1 95 1.67461e-39 Pediculus humanus corporis structural maintenance of chromosome, putative, mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 O97594 1951 3.8e-217 Structural maintenance of chromosomes protein 3 OS=Bos taurus GN=SMC3 PE=1 SV=1 PF13304//PF11427//PF04111//PF00005//PF06470//PF01580 AAA domain, putative AbiEii toxin, Type IV TA system//Tc3 transposase//Autophagy protein Apg6//ABC transporter//SMC proteins Flexible Hinge Domain//FtsK/SpoIIIE family GO:0007062//GO:0006310//GO:0030261//GO:0051276//GO:0006281//GO:0006914 sister chromatid cohesion//DNA recombination//chromosome condensation//chromosome organization//DNA repair//autophagy GO:0016887//GO:0000166//GO:0003677//GO:0005524//GO:0005515 ATPase activity//nucleotide binding//DNA binding//ATP binding//protein binding GO:0005694//GO:0005634 chromosome//nucleus KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.44711 BP_3 72.15 0.63 5770 91091932 XP_966409.1 1977 2.1e-218 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 827536550 XM_004921667.2 136 6.56975e-62 PREDICTED: Bombyx mori structural maintenance of chromosomes protein 3 (LOC101736252), mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 O93309 1082 5.3e-116 Structural maintenance of chromosomes protein 3 OS=Xenopus laevis GN=smc3 PE=1 SV=2 PF04210//PF05440//PF00614//PF05531//PF13304 Tetrahydromethanopterin S-methyltransferase, subunit G//Tetrahydromethanopterin S-methyltransferase subunit B//Phospholipase D Active site motif//Nucleopolyhedrovirus P10 protein//AAA domain, putative AbiEii toxin, Type IV TA system GO:0030261//GO:0006310//GO:0007062//GO:0046656//GO:0006281//GO:0015948 chromosome condensation//DNA recombination//sister chromatid cohesion//folic acid biosynthetic process//DNA repair//methanogenesis GO:0030269//GO:0005524//GO:0003824 tetrahydromethanopterin S-methyltransferase activity//ATP binding//catalytic activity GO:0005694//GO:0019028//GO:0005634//GO:0016021 chromosome//viral capsid//nucleus//integral component of membrane KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.44713 BP_3 1444.50 13.74 5359 91091932 XP_966409.1 1977 2.0e-218 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 827536550 XM_004921667.2 136 6.09885e-62 PREDICTED: Bombyx mori structural maintenance of chromosomes protein 3 (LOC101736252), mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 O93309 1082 4.9e-116 Structural maintenance of chromosomes protein 3 OS=Xenopus laevis GN=smc3 PE=1 SV=2 PF13304//PF05531//PF00614//PF04210//PF05440 AAA domain, putative AbiEii toxin, Type IV TA system//Nucleopolyhedrovirus P10 protein//Phospholipase D Active site motif//Tetrahydromethanopterin S-methyltransferase, subunit G//Tetrahydromethanopterin S-methyltransferase subunit B GO:0006281//GO:0046656//GO:0015948//GO:0030261//GO:0007062//GO:0006310 DNA repair//folic acid biosynthetic process//methanogenesis//chromosome condensation//sister chromatid cohesion//DNA recombination GO:0005524//GO:0003824//GO:0030269 ATP binding//catalytic activity//tetrahydromethanopterin S-methyltransferase activity GO:0016021//GO:0005634//GO:0019028//GO:0005694 integral component of membrane//nucleus//viral capsid//chromosome KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.44715 BP_3 249.59 2.38 5339 270002209 EEZ98656.1 2306 1.4e-256 hypothetical protein TcasGA2_TC001185 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1289 4.9e-140 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.44716 BP_3 10.11 0.35 1675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44717 BP_3 114.75 1.40 4239 642924682 XP_008194395.1 1811 2.8e-199 PREDICTED: voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [Tribolium castaneum] 642924681 XM_008196173.1 612 0 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X4, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 1236 5.4e-134 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF12052//PF08437//PF00018//PF01424 Voltage gated calcium channel subunit beta domain 4Aa N terminal//Glycosyl transferase family 8 C-terminal//SH3 domain//R3H domain GO:0009103//GO:0006816//GO:0070588 lipopolysaccharide biosynthetic process//calcium ion transport//calcium ion transmembrane transport GO:0005515//GO:0003676//GO:0005245//GO:0008918 protein binding//nucleic acid binding//voltage-gated calcium channel activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0005891 voltage-gated calcium channel complex KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.44718 BP_3 78.89 2.77 1665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44721 BP_3 1062.28 34.24 1787 646723939 KDR24373.1 1858 4.1e-205 T-complex protein 1 subunit gamma [Zootermopsis nevadensis] 124487747 EF091969.1 234 6.68131e-117 Maconellicoccus hirsutus clone WHMH3794 putative T-complex protein 1 subunit gamma mRNA, partial cds K09495 CCT3, TRIC5 T-complex protein 1 subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K09495 P48605 1813 2.8e-201 T-complex protein 1 subunit gamma OS=Drosophila melanogaster GN=Cctgamma PE=2 SV=2 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0364 Chaperonin complex component, TCP-1 gamma subunit (CCT3) Cluster-8309.44726 BP_3 71.77 3.77 1210 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44728 BP_3 8.19 0.39 1314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44730 BP_3 1.00 1.37 314 123439425 XP_001310484.1 185 7.2e-12 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121892256|gb|EAX97554.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q9STP8 161 1.8e-10 Acyl-CoA-binding domain-containing protein 2 OS=Arabidopsis thaliana GN=ACBP2 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44733 BP_3 51.22 0.35 7310 642912875 XP_008201292.1 4596 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X9 [Tribolium castaneum]>gi|270001881|gb|EEZ98328.1| hypothetical protein TcasGA2_TC000782 [Tribolium castaneum] 642912874 XM_008203070.1 1275 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1812 1.5e-200 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00784//PF00788//PF00781//PF00076//PF07649//PF00628//PF00609//PF00130 MyTH4 domain//Ras association (RalGDS/AF-6) domain//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C1-like domain//PHD-finger//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0046486//GO:0035556//GO:0055114//GO:0007205//GO:0009395//GO:0007165 glycerolipid metabolic process//intracellular signal transduction//oxidation-reduction process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//signal transduction GO:0003676//GO:0016301//GO:0000166//GO:0047134//GO:0046872//GO:0004143//GO:0005515 nucleic acid binding//kinase activity//nucleotide binding//protein-disulfide reductase activity//metal ion binding//diacylglycerol kinase activity//protein binding GO:0005622//GO:0005856 intracellular//cytoskeleton KOG1169 Diacylglycerol kinase Cluster-8309.44734 BP_3 1729.37 28.56 3210 478256479 ENN76664.1 1569 2.4e-171 hypothetical protein YQE_06843, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q869E1 144 1.7e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44736 BP_3 103.83 0.84 6263 270013964 EFA10412.1 5274 0.0e+00 hypothetical protein TcasGA2_TC012652 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 4.4e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.44737 BP_3 1832.92 25.58 3746 270017242 EFA13688.1 1493 1.8e-162 hypothetical protein TcasGA2_TC001594 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 1.1e-111 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF05118//PF02737//PF00515//PF04812//PF13414//PF13176//PF13181//PF13174 Aspartyl/Asparaginyl beta-hydroxylase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Tetratricopeptide repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0055114//GO:0006554//GO:0006552//GO:0045893//GO:0018193//GO:0006631//GO:0006568//GO:0006633//GO:0018874//GO:0006574//GO:0006550 oxidation-reduction process//lysine catabolic process//leucine catabolic process//positive regulation of transcription, DNA-templated//peptidyl-amino acid modification//fatty acid metabolic process//tryptophan metabolic process//fatty acid biosynthetic process//benzoate metabolic process//valine catabolic process//isoleucine catabolic process GO:0003857//GO:0016491//GO:0005515 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//protein binding GO:0005634 nucleus KOG3696 Aspartyl beta-hydroxylase Cluster-8309.44738 BP_3 153.74 1.98 4041 546672114 ERL84135.1 1143 7.6e-122 hypothetical protein D910_01486 [Dendroctonus ponderosae]>gi|546675290|gb|ERL86521.1| hypothetical protein D910_03927 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NAG6 531 2.9e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.44739 BP_3 49.12 0.53 4723 270015509 EFA11957.1 1503 1.6e-163 serine protease H82 [Tribolium castaneum] 641658676 XM_001951259.3 168 8.73543e-80 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- Q96EN8 486 5.6e-47 Molybdenum cofactor sulfurase OS=Homo sapiens GN=MOCOS PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.44740 BP_3 830.61 16.63 2699 642916167 XP_008190914.1 1078 1.7e-114 PREDICTED: uncharacterized protein LOC103312328 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44745 BP_3 56.60 1.20 2566 642929001 XP_008195650.1 2028 1.2e-224 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 845 7.1e-89 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF05986//PF08686 ADAM-TS Spacer 1//PLAC (protease and lacunin) domain -- -- GO:0008233//GO:0004222 peptidase activity//metalloendopeptidase activity GO:0031012 extracellular matrix KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.44748 BP_3 184.50 1.17 7911 642932112 XP_008196860.1 3146 0.0e+00 PREDICTED: ABC transporter G family member 14 isoform X1 [Tribolium castaneum] 642932111 XM_008198638.1 779 0 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X1, mRNA -- -- -- -- Q6WV17 1150 9.4e-124 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 PF00004//PF00437//PF01061//PF13304//PF01926//PF00910//PF10662//PF01637//PF00005//PF05418//PF03193 ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//RNA helicase//Ethanolamine utilisation - propanediol utilisation//Archaeal ATPase//ABC transporter//Apovitellenin I (Apo-VLDL-II)//Protein of unknown function, DUF258 GO:0006576//GO:0006629//GO:0006810 cellular biogenic amine metabolic process//lipid metabolic process//transport GO:0005525//GO:0016887//GO:0003724//GO:0003723//GO:0005524//GO:0004857//GO:0003924 GTP binding//ATPase activity//RNA helicase activity//RNA binding//ATP binding//enzyme inhibitor activity//GTPase activity GO:0016020//GO:0042627 membrane//chylomicron KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.44749 BP_3 57.77 0.37 7915 642932108 XP_008196858.1 2425 3.3e-270 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 1 isoform X1 [Tribolium castaneum]>gi|270011650|gb|EFA08098.1| hypothetical protein TcasGA2_TC005702 [Tribolium castaneum] 642932111 XM_008198638.1 553 0 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 1239 4.5e-134 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 PF10662//PF00910//PF00931//PF03193//PF05418//PF00005//PF01637//PF06422//PF00437//PF00004//PF02485//PF01926//PF13304//PF01061 Ethanolamine utilisation - propanediol utilisation//RNA helicase//NB-ARC domain//Protein of unknown function, DUF258//Apovitellenin I (Apo-VLDL-II)//ABC transporter//Archaeal ATPase//CDR ABC transporter//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Core-2/I-Branching enzyme//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC-2 type transporter GO:0006629//GO:0006576//GO:0006810//GO:0006486 lipid metabolic process//cellular biogenic amine metabolic process//transport//protein glycosylation GO:0004857//GO:0043531//GO:0003723//GO:0003724//GO:0005525//GO:0008375//GO:0003924//GO:0016757//GO:0005524//GO:0042626//GO:0016887 enzyme inhibitor activity//ADP binding//RNA binding//RNA helicase activity//GTP binding//acetylglucosaminyltransferase activity//GTPase activity//transferase activity, transferring glycosyl groups//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity GO:0016020//GO:0005794//GO:0016021//GO:0042627 membrane//Golgi apparatus//integral component of membrane//chylomicron KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.4475 BP_3 2.00 0.39 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44750 BP_3 118.75 1.16 5233 270004497 EFA00945.1 2146 4.9e-238 hypothetical protein TcasGA2_TC003854 [Tribolium castaneum] -- -- -- -- -- K14416 HBS1 elongation factor 1 alpha-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K14416 Q69ZS7 1399 8.4e-153 HBS1-like protein OS=Mus musculus GN=Hbs1l PE=1 SV=2 PF03144//PF05773//PF01926//PF09445 Elongation factor Tu domain 2//RWD domain//50S ribosome-binding GTPase//RNA cap guanine-N2 methyltransferase GO:0009452//GO:0001510 7-methylguanosine RNA capping//RNA methylation GO:0005525//GO:0008168//GO:0005515 GTP binding//methyltransferase activity//protein binding -- -- KOG0458 Elongation factor 1 alpha Cluster-8309.44752 BP_3 59.22 0.71 4320 642914513 XP_008201708.1 803 2.2e-82 PREDICTED: protein scalloped isoform X3 [Tribolium castaneum] 642914516 XM_008203488.1 273 3.4124e-138 PREDICTED: Tribolium castaneum scalloped (LOC658922), transcript variant X5, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 Q25214 564 4.6e-56 Protein scalloped (Fragment) OS=Junonia coenia GN=SD PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.44753 BP_3 19.26 0.37 2777 642934573 XP_008197722.1 2027 1.6e-224 PREDICTED: uncharacterized protein LOC658962 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10314 FBXO39 F-box protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K10314 -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44754 BP_3 34.18 0.64 2882 478250393 ENN70888.1 2076 3.5e-230 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 751 6.4e-78 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF03404//PF00107 Mo-co oxidoreductase dimerisation domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0030151 oxidoreductase activity//molybdenum ion binding -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.44756 BP_3 161.33 2.13 3951 570341982 AHE77387.1 1798 8.3e-198 heat shock protein 70, partial [Lissorhoptrus oryzophilus] 645000994 XM_001599723.3 244 4.12054e-122 PREDICTED: Nasonia vitripennis heat shock protein 68-like (LOC100114907), mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P41825 1624 5.1e-179 Heat shock protein 70 A1 OS=Anopheles albimanus GN=HSP70A1 PE=3 SV=1 PF00560//PF02782//PF13855 Leucine Rich Repeat//FGGY family of carbohydrate kinases, C-terminal domain//Leucine rich repeat GO:0005975 carbohydrate metabolic process GO:0005515//GO:0016773 protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.44759 BP_3 1.00 3.49 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44764 BP_3 1295.62 8.32 7799 270012248 EFA08696.1 940 5.1e-98 hypothetical protein TcasGA2_TC006367 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q8IX06 586 2.3e-58 Putative exonuclease GOR OS=Homo sapiens GN=REXO1L1P PE=5 SV=2 PF02932//PF03930//PF00400//PF00930//PF01612 Neurotransmitter-gated ion-channel transmembrane region//Recombinase Flp protein N-terminus//WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//3'-5' exonuclease GO:0006811//GO:0006508//GO:0006310//GO:0006139 ion transport//proteolysis//DNA recombination//nucleobase-containing compound metabolic process GO:0003676//GO:0008408//GO:0005515 nucleic acid binding//3'-5' exonuclease activity//protein binding GO:0016020 membrane KOG2248 3'-5' exonuclease Cluster-8309.44766 BP_3 671.10 9.82 3587 642933817 XP_008197388.1 674 1.6e-67 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TN34 370 1.2e-33 MICAL-like protein 2 OS=Mus musculus GN=Micall2 PE=1 SV=1 PF00307//PF00288 Calponin homology (CH) domain//GHMP kinases N terminal domain -- -- GO:0005515//GO:0005524 protein binding//ATP binding -- -- -- -- Cluster-8309.44768 BP_3 180.61 4.38 2279 642930218 XP_008196305.1 2314 7.0e-258 PREDICTED: protein UBASH3A homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 1098 2.9e-118 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.44770 BP_3 2608.73 33.39 4057 189241935 XP_969741.2 2165 2.4e-240 PREDICTED: coronin-2B-like isoform X2 [Tribolium castaneum] 612001587 XM_007485717.1 39 3.84971e-08 PREDICTED: Monodelphis domestica coronin 6 (CORO6), transcript variant X3, mRNA K13887 CORO2 coronin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13887 A8WGE3 1310 1.4e-142 Coronin-2B OS=Xenopus tropicalis GN=coro2b PE=2 SV=1 PF00400//PF04977 WD domain, G-beta repeat//Septum formation initiator GO:0007049 cell cycle GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.44771 BP_3 334.91 2.73 6213 478263644 ENN81950.1 1558 8.8e-170 hypothetical protein YQE_01661, partial [Dendroctonus ponderosae]>gi|546676683|gb|ERL87639.1| hypothetical protein D910_05030 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9I7H9 662 2.9e-67 Prolyl 3-hydroxylase sudestada1 OS=Drosophila melanogaster GN=sud1 PE=2 SV=1 PF07527//PF00010//PF03594//PF13640//PF10637 Hairy Orange//Helix-loop-helix DNA-binding domain//Benzoate membrane transport protein//2OG-Fe(II) oxygenase superfamily//Oxoglutarate and iron-dependent oxygenase degradation C-term GO:0006355//GO:0055114//GO:0042919//GO:0006810 regulation of transcription, DNA-templated//oxidation-reduction process//benzoate transport//transport GO:0016706//GO:0031418//GO:0042925//GO:0005506//GO:0003677//GO:0046983//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//L-ascorbic acid binding//benzoate transporter activity//iron ion binding//DNA binding//protein dimerization activity//oxidoreductase activity GO:0016021 integral component of membrane -- -- Cluster-8309.44774 BP_3 270.35 1.67 8106 91086329 XP_967308.1 2183 3.9e-242 PREDICTED: protein pellino isoform X3 [Tribolium castaneum] 642927955 XM_962215.3 371 0 PREDICTED: Tribolium castaneum protein pellino (LOC662980), transcript variant X3, mRNA K11964 PELI pellino http://www.genome.jp/dbget-bin/www_bget?ko:K11964 O77237 1765 4.7e-195 Protein pellino OS=Drosophila melanogaster GN=Pli PE=1 SV=1 PF01899//PF13639//PF15723//PF04710//PF13897//PF05203//PF14634 Na+/H+ ion antiporter subunit//Ring finger domain//Motility quorum-sensing regulator, toxin of MqsA//Pellino//Golgi-dynamics membrane-trafficking//Hom_end-associated Hint//zinc-RING finger domain GO:0008063//GO:0030908//GO:0006810//GO:0006812//GO:0017148//GO:0042710//GO:0009372 Toll signaling pathway//protein splicing//transport//cation transport//negative regulation of translation//biofilm formation//quorum sensing GO:0005515//GO:0008324//GO:0008270 protein binding//cation transmembrane transporter activity//zinc ion binding GO:0016021 integral component of membrane KOG3842 Adaptor protein Pellino Cluster-8309.44777 BP_3 1901.89 19.74 4936 642917920 XP_008200607.1 2695 1.0e-301 PREDICTED: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [Tribolium castaneum] -- -- -- -- -- K00738 MGAT4A_B alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B http://www.genome.jp/dbget-bin/www_bget?ko:K00738 Q6GMK0 1217 1.0e-131 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B OS=Danio rerio GN=mgat4b PE=2 SV=1 PF01991//PF04666 ATP synthase (E/31 kDa) subunit//N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region GO:0015992//GO:0005975//GO:0006119//GO:0015991 proton transport//carbohydrate metabolic process//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961//GO:0016758 proton-transporting ATPase activity, rotational mechanism//transferase activity, transferring hexosyl groups GO:0016020//GO:0033178 membrane//proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.44779 BP_3 269.19 1.86 7250 91076138 XP_970159.1 2672 6.9e-299 PREDICTED: catenin alpha [Tribolium castaneum]>gi|642911687|ref|XP_008200701.1| PREDICTED: catenin alpha [Tribolium castaneum]>gi|642911689|ref|XP_008200702.1| PREDICTED: catenin alpha [Tribolium castaneum]>gi|270014573|gb|EFA11021.1| hypothetical protein TcasGA2_TC004609 [Tribolium castaneum] 642911688 XM_008202480.1 594 0 PREDICTED: Tribolium castaneum catenin alpha (LOC658703), transcript variant X3, mRNA K05691 CTNNA catenin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05691 P35220 2281 6.2e-255 Catenin alpha OS=Drosophila melanogaster GN=alpha-Cat PE=1 SV=2 PF08919//PF00328//PF03223//PF00639//PF01044//PF01608//PF00435//PF04632 F-actin binding//Histidine phosphatase superfamily (branch 2)//V-ATPase subunit C//PPIC-type PPIASE domain//Vinculin family//I/LWEQ domain//Spectrin repeat//Fusaric acid resistance protein family GO:0006810//GO:0019497//GO:0006468//GO:0015992//GO:0015991//GO:0006771//GO:0007155 transport//hexachlorocyclohexane metabolic process//protein phosphorylation//proton transport//ATP hydrolysis coupled proton transport//riboflavin metabolic process//cell adhesion GO:0003779//GO:0005198//GO:0045296//GO:0005524//GO:0003993//GO:0051015//GO:0015078//GO:0005515//GO:0016853//GO:0004715 actin binding//structural molecule activity//cadherin binding//ATP binding//acid phosphatase activity//actin filament binding//hydrogen ion transmembrane transporter activity//protein binding//isomerase activity//non-membrane spanning protein tyrosine kinase activity GO:0033180//GO:0015629//GO:0005886 proton-transporting V-type ATPase, V1 domain//actin cytoskeleton//plasma membrane KOG3681 Alpha-catenin Cluster-8309.44786 BP_3 339.32 3.50 4965 91084129 XP_969781.1 4516 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 51 1.00714e-14 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA -- -- -- -- Q54U44 1414 1.4e-154 ABC transporter C family member 12 OS=Dictyostelium discoideum GN=abcC12 PE=3 SV=1 PF03193//PF00005//PF01637//PF02456//PF06552//PF00931//PF08477//PF01926//PF13304//PF00664//PF00437 Protein of unknown function, DUF258//ABC transporter//Archaeal ATPase//Adenovirus IVa2 protein//Plant specific mitochondrial import receptor subunit TOM20//NB-ARC domain//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0055085//GO:0019083//GO:0006810//GO:0045040//GO:0007264//GO:0009987 transmembrane transport//viral transcription//transport//protein import into mitochondrial outer membrane//small GTPase mediated signal transduction//cellular process GO:0005524//GO:0043531//GO:0003924//GO:0005525//GO:0000166//GO:0016887//GO:0042626 ATP binding//ADP binding//GTPase activity//GTP binding//nucleotide binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0005742 integral component of membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.44789 BP_3 89.23 1.39 3381 478253357 ENN73716.1 926 9.3e-97 hypothetical protein YQE_09686, partial [Dendroctonus ponderosae]>gi|478266907|gb|ENN82945.1| hypothetical protein YQE_00690, partial [Dendroctonus ponderosae]>gi|546681927|gb|ERL91923.1| hypothetical protein D910_09246 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2ABP2 551 1.2e-54 Post-GPI attachment to proteins factor 2 OS=Cricetulus griseus GN=Pgap2 PE=2 SV=1 PF01848 Hok/gef family -- -- -- -- GO:0016020 membrane KOG3979 FGF receptor activating protein 1 Cluster-8309.44791 BP_3 2348.48 26.51 4561 642911425 XP_008199417.1 1790 8.1e-197 PREDICTED: uncharacterized protein LOC103314658 [Tribolium castaneum]>gi|270014802|gb|EFA11250.1| hypothetical protein TcasGA2_TC010783 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62675 357 4.9e-32 Pro-interleukin-16 OS=Macaca mulatta GN=IL16 PE=2 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.44793 BP_3 66.11 0.55 6088 642911425 XP_008199417.1 1219 1.8e-130 PREDICTED: uncharacterized protein LOC103314658 [Tribolium castaneum]>gi|270014802|gb|EFA11250.1| hypothetical protein TcasGA2_TC010783 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62675 290 3.8e-24 Pro-interleukin-16 OS=Macaca mulatta GN=IL16 PE=2 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44797 BP_3 241.52 1.75 6949 642917278 XP_008199232.1 1608 1.6e-175 PREDICTED: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform X2 [Tribolium castaneum] 685047512 LN596024.1 38 2.37935e-07 Cyprinus carpio genome assembly common carp genome ,scaffold 000002447 K16513 NOS1AP, CAPON carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein http://www.genome.jp/dbget-bin/www_bget?ko:K16513 O54960 737 6.4e-76 Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Rattus norvegicus GN=Nos1ap PE=1 SV=1 PF00640 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4815 Muscular protein implicated in muscular dystrophy phenotype Cluster-8309.44798 BP_3 253.32 1.83 6965 642917278 XP_008199232.1 1608 1.6e-175 PREDICTED: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform X2 [Tribolium castaneum] 685047512 LN596024.1 38 2.38486e-07 Cyprinus carpio genome assembly common carp genome ,scaffold 000002447 K16513 NOS1AP, CAPON carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein http://www.genome.jp/dbget-bin/www_bget?ko:K16513 O54960 737 6.5e-76 Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Rattus norvegicus GN=Nos1ap PE=1 SV=1 PF00640 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4815 Muscular protein implicated in muscular dystrophy phenotype Cluster-8309.44799 BP_3 124.79 3.20 2174 91077688 XP_974709.1 1738 4.1e-191 PREDICTED: protein PTCD3 homolog, mitochondrial [Tribolium castaneum]>gi|270001531|gb|EEZ97978.1| hypothetical protein TcasGA2_TC000373 [Tribolium castaneum] -- -- -- -- -- K17659 PTCD3 pentatricopeptide repeat domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17659 A1Z9A8 1410 1.8e-154 Protein PTCD3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4679 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.448 BP_3 1.00 1.49 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44800 BP_3 606.21 15.97 2121 91077688 XP_974709.1 2028 9.5e-225 PREDICTED: protein PTCD3 homolog, mitochondrial [Tribolium castaneum]>gi|270001531|gb|EEZ97978.1| hypothetical protein TcasGA2_TC000373 [Tribolium castaneum] -- -- -- -- -- K17659 PTCD3 pentatricopeptide repeat domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17659 A1Z9A8 1606 3.4e-177 Protein PTCD3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4679 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44802 BP_3 3.00 1.68 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44803 BP_3 2951.50 15.92 9227 91083997 XP_975257.1 1901 2.2e-209 PREDICTED: phosphatidate cytidylyltransferase, photoreceptor-specific [Tribolium castaneum]>gi|270007993|gb|EFA04441.1| hypothetical protein TcasGA2_TC014743 [Tribolium castaneum] 729297249 XM_010548190.1 40 2.44555e-08 PREDICTED: Tarenaya hassleriana phosphatidate cytidylyltransferase (LOC104818548), transcript variant X5, mRNA K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 1615 1.3e-177 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 PF12861//PF12906//PF12678//PF05485//PF14604//PF00018//PF13639 Anaphase-promoting complex subunit 11 RING-H2 finger//RING-variant domain//RING-H2 zinc finger//THAP domain//Variant SH3 domain//SH3 domain//Ring finger domain GO:0016024//GO:0046486//GO:0008654//GO:0016567 CDP-diacylglycerol biosynthetic process//glycerolipid metabolic process//phospholipid biosynthetic process//protein ubiquitination GO:0003676//GO:0008270//GO:0004605//GO:0005515//GO:0004842 nucleic acid binding//zinc ion binding//phosphatidate cytidylyltransferase activity//protein binding//ubiquitin-protein transferase activity GO:0016021//GO:0005680 integral component of membrane//anaphase-promoting complex KOG1440 CDP-diacylglycerol synthase Cluster-8309.44806 BP_3 419.00 8.97 2542 642924866 XP_008194074.1 942 9.7e-99 PREDICTED: protein crossbronx homolog [Tribolium castaneum] 665792379 XM_008545569.1 54 1.10136e-16 PREDICTED: Microplitis demolitor UPF0598 protein CG30010 (LOC103568629), transcript variant X3, mRNA -- -- -- -- Q7K4V4 498 1.2e-48 Protein crossbronx OS=Drosophila melanogaster GN=cbx PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.44807 BP_3 296.18 3.44 4438 332375999 AEE63140.1 1341 9.2e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DGR4 833 3.0e-87 Protein HGH1 homolog OS=Danio rerio GN=hgh1 PE=2 SV=1 PF05485//PF00096 THAP domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- KOG2973 Uncharacterized conserved protein Cluster-8309.44810 BP_3 2400.59 30.86 4041 91092998 XP_968397.1 1000 2.9e-105 PREDICTED: ras-related protein Rac1 [Tribolium castaneum]>gi|270004802|gb|EFA01250.1| Ras-related protein Rac1 [Tribolium castaneum] 751452676 XM_011182416.1 179 5.72962e-86 PREDICTED: Bactrocera cucurbitae ras-related protein Rac1 (LOC105211120), mRNA K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 P40792 956 1.5e-101 Ras-related protein Rac1 OS=Drosophila melanogaster GN=Rac1 PE=1 SV=2 PF08477//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0005622//GO:0016020 intracellular//membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.44812 BP_3 55.33 1.67 1884 332374412 AEE62347.1 607 5.0e-60 unknown [Dendroctonus ponderosae]>gi|478255244|gb|ENN75473.1| hypothetical protein YQE_08022, partial [Dendroctonus ponderosae]>gi|546671879|gb|ERL83998.1| hypothetical protein D910_01314 [Dendroctonus ponderosae]>gi|546679662|gb|ERL90089.1| hypothetical protein D910_07443 [Dendroctonus ponderosae] -- -- -- -- -- K13347 PXMP2, PMP22 peroxisomal membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13347 Q9ZS51 170 9.7e-11 Peroxisomal membrane protein PMP22 OS=Arabidopsis thaliana GN=PMP22 PE=1 SV=1 PF06027//PF04117 Solute carrier family 35//Mpv17 / PMP22 family GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.44813 BP_3 64.90 0.81 4137 546674815 ERL86101.1 1860 5.6e-205 hypothetical protein D910_03515 [Dendroctonus ponderosae] 815800151 XM_012365304.1 53 6.47779e-16 PREDICTED: Linepithema humile uncharacterized LOC105671296 (LOC105671296), transcript variant X3, mRNA -- -- -- -- B0UYT5 156 9.0e-09 Major facilitator superfamily domain-containing protein 6-B OS=Danio rerio GN=mfsd6b PE=3 SV=1 PF01306//PF07690 LacY proton/sugar symporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.44814 BP_3 62.25 2.13 1698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0015992//GO:0006814//GO:0006120//GO:0006744 proton transport//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.44816 BP_3 892.89 80.40 827 332374374 AEE62328.1 687 1.2e-69 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44817 BP_3 188.12 3.18 3144 91089355 XP_972978.1 757 3.4e-77 PREDICTED: innexin inx2 [Tribolium castaneum]>gi|270011438|gb|EFA07886.1| hypothetical protein TcasGA2_TC005460 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XYN1 619 1.4e-62 Innexin inx2 OS=Schistocerca americana GN=inx2 PE=1 SV=1 PF00876//PF08587 Innexin//Ubiquitin associated domain (UBA) GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0004674 protein serine/threonine kinase activity GO:0005921 gap junction -- -- Cluster-8309.44818 BP_3 1160.45 32.40 2018 91088421 XP_967011.1 289 4.0e-23 PREDICTED: activated RNA polymerase II transcriptional coactivator p15 [Tribolium castaneum]>gi|270012200|gb|EFA08648.1| hypothetical protein TcasGA2_TC006312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11031 175 2.7e-11 Activated RNA polymerase II transcriptional coactivator p15 OS=Mus musculus GN=Sub1 PE=1 SV=3 PF02229 Transcriptional Coactivator p15 (PC4) GO:0006355 regulation of transcription, DNA-templated GO:0003713//GO:0003677 transcription coactivator activity//DNA binding GO:0005667 transcription factor complex KOG2712 Transcriptional coactivator Cluster-8309.44820 BP_3 566.30 3.41 8304 170042086 XP_001848770.1 1358 1.8e-146 RING finger protein 121 [Culex quinquefasciatus]>gi|167865628|gb|EDS29011.1| RING finger protein 121 [Culex quinquefasciatus] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q6DD32 1112 2.5e-119 RING finger protein 121 OS=Xenopus laevis GN=rnf121 PE=2 SV=1 PF02687//PF00097//PF14634//PF17123//PF12678//PF13639//PF12861//PF09773 FtsX-like permease family//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-like zinc finger//RING-H2 zinc finger//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Meckelin (Transmembrane protein 67) GO:0010826//GO:0042384//GO:0016567 negative regulation of centrosome duplication//cilium assembly//protein ubiquitination GO:0046872//GO:0008270//GO:0004842//GO:0005515 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding GO:0036038//GO:0016020//GO:0005680 TCTN-B9D complex//membrane//anaphase-promoting complex KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.44822 BP_3 867.00 10.13 4415 91089371 XP_973545.1 3861 0.0e+00 PREDICTED: calcium-activated chloride channel regulator 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54281 456 1.6e-43 Epithelial chloride channel protein OS=Bos taurus PE=2 SV=1 PF02480//PF10462 Alphaherpesvirus glycoprotein E//Peptidase M66 -- -- GO:0004222 metalloendopeptidase activity GO:0016020 membrane -- -- Cluster-8309.44825 BP_3 427.61 3.37 6406 642938167 XP_008190994.1 878 6.5e-91 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NQ0 408 8.4e-38 G-protein coupled receptor Mth2 OS=Drosophila simulans GN=mth2 PE=3 SV=1 PF00002//PF00001//PF04644 7 transmembrane receptor (Secretin family)//7 transmembrane receptor (rhodopsin family)//Motilin/ghrelin GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005179//GO:0004930 hormone activity//G-protein coupled receptor activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.44827 BP_3 243.00 6.76 2025 478266386 ENN82777.1 1064 5.5e-113 hypothetical protein YQE_00855, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 336 5.9e-30 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.44828 BP_3 73.05 1.50 2646 642935358 XP_008197980.1 1191 1.4e-127 PREDICTED: uncharacterized protein LOC657906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44831 BP_3 232.24 1.29 8959 642916561 XP_008191701.1 2302 6.8e-256 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] 642916712 XM_001813000.2 329 5.26391e-169 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100141653), mRNA -- -- -- -- Q5T2T1 1155 2.8e-124 MAGUK p55 subfamily member 7 OS=Homo sapiens GN=MPP7 PE=1 SV=1 PF00651//PF14604//PF00018//PF00595//PF05225//PF13180 BTB/POZ domain//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF)//helix-turn-helix, Psq domain//PDZ domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.44833 BP_3 11.00 0.63 1138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44834 BP_3 2084.55 27.15 3993 91082721 XP_972476.1 730 5.8e-74 PREDICTED: uncharacterized protein LOC661208 [Tribolium castaneum]>gi|270014957|gb|EFA11405.1| hypothetical protein TcasGA2_TC013579 [Tribolium castaneum] -- -- -- -- -- K16678 EGR eiger http://www.genome.jp/dbget-bin/www_bget?ko:K16678 -- -- -- -- PF00229 TNF(Tumour Necrosis Factor) family GO:0006955//GO:0007165 immune response//signal transduction GO:0005164 tumor necrosis factor receptor binding GO:0016020 membrane -- -- Cluster-8309.44835 BP_3 86.80 0.39 11045 642918318 XP_008191457.1 7327 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 195492470 XM_002093969.1 257 6.8728e-129 Drosophila yakuba GE20438 (Dyak\GE20438), partial mRNA -- -- -- -- Q9VS29 6236 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF04120//PF00041//PF16656//PF07749 Immunoglobulin domain//Low affinity iron permease//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Endoplasmic reticulum protein ERp29, C-terminal domain GO:0019497//GO:0006771//GO:0055085 hexachlorocyclohexane metabolic process//riboflavin metabolic process//transmembrane transport GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.44837 BP_3 181.00 4.85 2089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44838 BP_3 2007.10 11.41 8773 546685536 ERL95023.1 3214 0.0e+00 hypothetical protein D910_12293 [Dendroctonus ponderosae] 780637936 XM_011688946.1 186 1.6048e-89 PREDICTED: Wasmannia auropunctata LIM domain kinase 1 (LOC105449641), transcript variant X2, mRNA K05743 LIMK1 LIM domain kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05743 Q8IR79 1694 8.7e-187 LIM domain kinase 1 OS=Drosophila melanogaster GN=LIMK1 PE=1 SV=1 PF10392//PF05929//PF00595//PF05478//PF07851//PF05531//PF06009//PF16331//PF02601//PF04513//PF04728//PF01621//PF00412//PF16740//PF00170//PF04871//PF00069//PF07714//PF07544//PF08289//PF06293//PF10473//PF06160 Golgi transport complex subunit 5//Phage capsid scaffolding protein (GPO) serine peptidase//PDZ domain (Also known as DHR or GLGF)//Prominin//TMPIT-like protein//Nucleopolyhedrovirus P10 protein//Laminin Domain II//TolA binding protein trimerisation//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//Lipoprotein leucine-zipper//Cell fusion glycoprotein K//LIM domain//Spindle and kinetochore-associated protein 2//bZIP transcription factor//Uso1 / p115 like vesicle tethering protein, C terminal region//Protein kinase domain//Protein tyrosine kinase//RNA polymerase II transcription mediator complex subunit 9//Influenza Matrix protein (M1) C-terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA GO:0006891//GO:0000921//GO:0051301//GO:0006357//GO:0007155//GO:0019069//GO:0006308//GO:0031110//GO:0000090//GO:0006355//GO:0007067//GO:0007059//GO:0015031//GO:0006886//GO:0070206//GO:0006468 intra-Golgi vesicle-mediated transport//septin ring assembly//cell division//regulation of transcription from RNA polymerase II promoter//cell adhesion//viral capsid assembly//DNA catabolic process//regulation of microtubule polymerization or depolymerization//mitotic anaphase//regulation of transcription, DNA-templated//mitotic nuclear division//chromosome segregation//protein transport//intracellular protein transport//protein trimerization//protein phosphorylation GO:0016773//GO:0004672//GO:0001104//GO:0003700//GO:0005524//GO:0008134//GO:0045502//GO:0008017//GO:0042803//GO:0003723//GO:0005515//GO:0008855//GO:0008565//GO:0043565//GO:0008270//GO:0005198 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//RNA polymerase II transcription cofactor activity//transcription factor activity, sequence-specific DNA binding//ATP binding//transcription factor binding//dynein binding//microtubule binding//protein homodimerization activity//RNA binding//protein binding//exodeoxyribonuclease VII activity//protein transporter activity//sequence-specific DNA binding//zinc ion binding//structural molecule activity GO:0030286//GO:0016592//GO:0005667//GO:0009318//GO:0019028//GO:0045298//GO:0017119//GO:0000940//GO:0016020//GO:0019867//GO:0019031//GO:0005876//GO:0005737//GO:0016021//GO:0005940 dynein complex//mediator complex//transcription factor complex//exodeoxyribonuclease VII complex//viral capsid//tubulin complex//Golgi transport complex//condensed chromosome outer kinetochore//membrane//outer membrane//viral envelope//spindle microtubule//cytoplasm//integral component of membrane//septin ring -- -- Cluster-8309.44839 BP_3 150.60 2.77 2911 338224398 AEI88080.1 332 6.0e-28 midline fasciclin [Scylla paramamosain] 338224397 HM217842.1 193 6.78584e-94 Scylla paramamosain isolate 1 midline fasciclin mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44840 BP_3 1873.34 14.94 6335 642919657 XP_008192010.1 2446 9.7e-273 PREDICTED: kinesin light chain isoform X2 [Tribolium castaneum]>gi|270005876|gb|EFA02324.1| hypothetical protein TcasGA2_TC007992 [Tribolium castaneum] 817205684 XM_012423337.1 328 1.33643e-168 PREDICTED: Orussus abietinus kinesin light chain (LOC105698786), transcript variant X2, mRNA K10407 KLC kinesin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10407 P46824 1708 1.5e-188 Kinesin light chain OS=Drosophila melanogaster GN=Klc PE=1 SV=1 PF13181//PF06156//PF13174//PF03836//PF13374//PF00515//PF00637//PF13414//PF11365//PF13176 Tetratricopeptide repeat//Protein of unknown function (DUF972)//Tetratricopeptide repeat//RasGAP C-terminus//Tetratricopeptide repeat//Tetratricopeptide repeat//Region in Clathrin and VPS//TPR repeat//Protein of unknown function (DUF3166)//Tetratricopeptide repeat GO:0010506//GO:0016192//GO:0006886//GO:0007017//GO:0006260//GO:0007264 regulation of autophagy//vesicle-mediated transport//intracellular protein transport//microtubule-based process//DNA replication//small GTPase mediated signal transduction GO:0005096//GO:0005515//GO:0003777 GTPase activator activity//protein binding//microtubule motor activity GO:0005874//GO:0005871//GO:0005615 microtubule//kinesin complex//extracellular space KOG1840 Kinesin light chain Cluster-8309.44843 BP_3 158.24 2.76 3055 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 5.95432e-40 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 1.3e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.44844 BP_3 18.17 0.39 2530 91076598 XP_968579.1 1385 4.1e-150 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 4.92239e-40 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9HBG4 935 2.6e-99 V-type proton ATPase 116 kDa subunit a isoform 4 OS=Homo sapiens GN=ATP6V0A4 PE=1 SV=2 PF02060//PF01496 Slow voltage-gated potassium channel//V-type ATPase 116kDa subunit family GO:0006811//GO:0015992//GO:0015991//GO:0006813 ion transport//proton transport//ATP hydrolysis coupled proton transport//potassium ion transport GO:0015078//GO:0005249 hydrogen ion transmembrane transporter activity//voltage-gated potassium channel activity GO:0016020//GO:0008076//GO:0033179 membrane//voltage-gated potassium channel complex//proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.44846 BP_3 262.75 3.14 4321 340723622 XP_003400188.1 3201 0.0e+00 PREDICTED: protein brunelleschi isoform X1 [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q6PA97 1528 7.6e-168 Trafficking protein particle complex subunit 9 OS=Xenopus laevis GN=trappc9 PE=2 SV=1 PF00515 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1953 Targeting complex (TRAPP) subunit Cluster-8309.44847 BP_3 1216.95 5.96 10127 642938459 XP_008199812.1 3950 0.0e+00 PREDICTED: Niemann-Pick C1 protein isoform X3 [Tribolium castaneum] 657584210 XM_008298026.1 56 3.42453e-17 PREDICTED: Stegastes partitus Niemann-Pick disease, type C1 (npc1), transcript variant X2, mRNA K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 P56941 2256 6.8e-252 Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1 PF03402//PF07677//PF03176//PF02460 Vomeronasal organ pheromone receptor family, V1R//A-macroglobulin receptor//MMPL family//Patched family GO:0007186//GO:0019236//GO:0007606//GO:0007165 G-protein coupled receptor signaling pathway//response to pheromone//sensory perception of chemical stimulus//signal transduction GO:0008158//GO:0016503 hedgehog receptor activity//pheromone receptor activity GO:0016020//GO:0005576//GO:0016021 membrane//extracellular region//integral component of membrane KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.44848 BP_3 1245.85 19.48 3375 270000870 EEZ97317.1 1789 7.9e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.36855e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.5e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.44849 BP_3 193.33 2.12 4687 478259245 ENN79147.1 3115 0.0e+00 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] 260807434 XM_002598468.1 159 8.72987e-75 Branchiostoma floridae hypothetical protein, mRNA K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 2572 7.2e-289 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF00004//PF07728//PF01745//PF08752//PF01695//PF00158//PF01926//PF01057//PF00931//PF02367//PF07724//PF06068//PF05496//PF00910//PF06800//PF07726//PF00005//PF01299//PF01637 ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Isopentenyl transferase//Coatomer gamma subunit appendage platform subdomain//IstB-like ATP binding protein//Sigma-54 interaction domain//50S ribosome-binding GTPase//Parvovirus non-structural protein NS1//NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//AAA domain (Cdc48 subfamily)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//RNA helicase//Sugar transport protein//ATPase family associated with various cellular activities (AAA)//ABC transporter//Lysosome-associated membrane glycoprotein (Lamp)//Archaeal ATPase GO:0002949//GO:0006310//GO:0008643//GO:0019079//GO:0016114//GO:0016192//GO:0006281//GO:0006886//GO:0006355//GO:0006694//GO:0034219//GO:0009058 tRNA threonylcarbamoyladenosine modification//DNA recombination//carbohydrate transport//viral genome replication//terpenoid biosynthetic process//vesicle-mediated transport//DNA repair//intracellular protein transport//regulation of transcription, DNA-templated//steroid biosynthetic process//carbohydrate transmembrane transport//biosynthetic process GO:0003678//GO:0003723//GO:0043531//GO:0005525//GO:0009378//GO:0003724//GO:0005524//GO:0005198//GO:0015144//GO:0008134//GO:0004161//GO:0016887 DNA helicase activity//RNA binding//ADP binding//GTP binding//four-way junction helicase activity//RNA helicase activity//ATP binding//structural molecule activity//carbohydrate transmembrane transporter activity//transcription factor binding//dimethylallyltranstransferase activity//ATPase activity GO:0005657//GO:0005667//GO:0016020//GO:0016021//GO:0009379//GO:0030126 replication fork//transcription factor complex//membrane//integral component of membrane//Holliday junction helicase complex//COPI vesicle coat KOG0741 AAA+-type ATPase Cluster-8309.4485 BP_3 4.00 0.58 622 102940 240 5.9e-18 hypothetical protein 3 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44850 BP_3 390.25 4.29 4681 478259245 ENN79147.1 3115 0.0e+00 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] 260807434 XM_002598468.1 165 4.02778e-78 Branchiostoma floridae hypothetical protein, mRNA K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 2572 7.2e-289 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF00931//PF02367//PF00004//PF00158//PF01926//PF01057//PF07728//PF01745//PF01695//PF08752//PF00910//PF06800//PF01637//PF07726//PF01299//PF00005//PF07724//PF06068//PF05496 NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//50S ribosome-binding GTPase//Parvovirus non-structural protein NS1//AAA domain (dynein-related subfamily)//Isopentenyl transferase//IstB-like ATP binding protein//Coatomer gamma subunit appendage platform subdomain//RNA helicase//Sugar transport protein//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//Lysosome-associated membrane glycoprotein (Lamp)//ABC transporter//AAA domain (Cdc48 subfamily)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus GO:0008643//GO:0002949//GO:0006310//GO:0016192//GO:0006281//GO:0006886//GO:0016114//GO:0019079//GO:0034219//GO:0009058//GO:0006694//GO:0006355 carbohydrate transport//tRNA threonylcarbamoyladenosine modification//DNA recombination//vesicle-mediated transport//DNA repair//intracellular protein transport//terpenoid biosynthetic process//viral genome replication//carbohydrate transmembrane transport//biosynthetic process//steroid biosynthetic process//regulation of transcription, DNA-templated GO:0043531//GO:0003678//GO:0003723//GO:0009378//GO:0003724//GO:0005525//GO:0015144//GO:0008134//GO:0005198//GO:0005524//GO:0004161//GO:0016887 ADP binding//DNA helicase activity//RNA binding//four-way junction helicase activity//RNA helicase activity//GTP binding//carbohydrate transmembrane transporter activity//transcription factor binding//structural molecule activity//ATP binding//dimethylallyltranstransferase activity//ATPase activity GO:0005667//GO:0005657//GO:0016020//GO:0016021//GO:0009379//GO:0030126 transcription factor complex//replication fork//membrane//integral component of membrane//Holliday junction helicase complex//COPI vesicle coat KOG0741 AAA+-type ATPase Cluster-8309.44851 BP_3 335.11 13.85 1458 546677198 ERL88080.1 790 2.3e-81 hypothetical protein D910_05469 [Dendroctonus ponderosae] -- -- -- -- -- K15262 BCP1, BCCIP protein BCP1 http://www.genome.jp/dbget-bin/www_bget?ko:K15262 Q9VFR0 496 1.2e-48 Protein BCCIP homolog OS=Drosophila melanogaster GN=CG9286 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3034 Isoamyl acetate-hydrolyzing esterase and related enzymes Cluster-8309.44852 BP_3 504.58 6.97 3783 189240899 XP_972980.2 1488 7.0e-162 PREDICTED: protein numb isoform X1 [Tribolium castaneum] 642934702 XM_967887.3 381 0 PREDICTED: Tribolium castaneum protein numb (LOC661741), transcript variant X1, mRNA K06057 NUMBL numb http://www.genome.jp/dbget-bin/www_bget?ko:K06057 P16554 1106 5.7e-119 Protein numb OS=Drosophila melanogaster GN=numb PE=1 SV=2 PF14719//PF08168//PF00640//PF07353 Phosphotyrosine interaction domain (PTB/PID)//NUC205 domain//Phosphotyrosine interaction domain (PTB/PID)//Uroplakin II GO:0061024 membrane organization GO:0005515 protein binding GO:0030176//GO:0005634 integral component of endoplasmic reticulum membrane//nucleus KOG3537 Adaptor protein NUMB Cluster-8309.44853 BP_3 106.84 1.10 4985 189236066 XP_971573.2 1275 4.6e-137 PREDICTED: protein SMG9 [Tribolium castaneum] -- -- -- -- -- K18735 SMG9 protein SMG9 http://www.genome.jp/dbget-bin/www_bget?ko:K18735 Q05AW9 527 1.0e-51 Protein SMG9 OS=Xenopus laevis GN=smg9 PE=2 SV=1 PF09268//PF00005//PF03193//PF00931//PF00910//PF01445//PF00071//PF01926//PF08477//PF00735//PF10220 Clathrin, heavy-chain linker//ABC transporter//Protein of unknown function, DUF258//NB-ARC domain//RNA helicase//Viral small hydrophobic protein//Ras family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//Uncharacterized conserved protein (DUF2146) GO:0000184//GO:0006886//GO:0016192//GO:0007264 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//intracellular protein transport//vesicle-mediated transport//small GTPase mediated signal transduction GO:0003723//GO:0005524//GO:0043531//GO:0005198//GO:0003924//GO:0005525//GO:0016887//GO:0003724 RNA binding//ATP binding//ADP binding//structural molecule activity//GTPase activity//GTP binding//ATPase activity//RNA helicase activity GO:0030132//GO:0016020//GO:0030130 clathrin coat of coated pit//membrane//clathrin coat of trans-Golgi network vesicle KOG4181 Uncharacterized conserved protein Cluster-8309.44854 BP_3 1980.39 15.20 6571 270008878 EFA05326.1 1129 5.2e-120 hypothetical protein TcasGA2_TC015490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 347 1.0e-30 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF00089//PF04277//PF15957//PF03067 Trypsin//Oxaloacetate decarboxylase, gamma chain//Commissureless//Chitin binding domain GO:0006525//GO:0007411//GO:0006560//GO:0006090//GO:0006508//GO:0071436//GO:0006814 arginine metabolic process//axon guidance//proline metabolic process//pyruvate metabolic process//proteolysis//sodium ion export//sodium ion transport GO:0008948//GO:0004252//GO:0015081 oxaloacetate decarboxylase activity//serine-type endopeptidase activity//sodium ion transmembrane transporter activity GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-8309.44855 BP_3 176.99 11.94 1006 642937671 XP_008198895.1 179 1.1e-10 PREDICTED: E3 ubiquitin-protein ligase RNF19A-like [Tribolium castaneum]>gi|642937673|ref|XP_008198896.1| PREDICTED: E3 ubiquitin-protein ligase RNF19A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44859 BP_3 251.40 9.85 1522 642929512 XP_975068.2 1084 2.0e-115 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Tribolium castaneum] 727003473 XM_010393578.1 39 1.4241e-08 PREDICTED: Corvus cornix cornix 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA K01082 cysQ, MET22, BPNT1 3'(2'), 5'-bisphosphate nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01082 O95861 750 4.4e-78 3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens GN=BPNT1 PE=1 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.44860 BP_3 374.38 1.60 11553 478250013 ENN70519.1 1319 8.5e-142 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 249 4.1e-19 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF01280//PF02388 Ribosomal protein L19e//FemAB family GO:0009252//GO:0006412//GO:0042254 peptidoglycan biosynthetic process//translation//ribosome biogenesis GO:0016755//GO:0003735 transferase activity, transferring amino-acyl groups//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.44861 BP_3 136.86 3.82 2017 642931187 XP_008196474.1 308 2.5e-25 PREDICTED: uncharacterized protein LOC103313868 [Tribolium castaneum]>gi|270012111|gb|EFA08559.1| hypothetical protein TcasGA2_TC006214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44862 BP_3 238.74 2.53 4843 642915277 XP_008190552.1 1610 6.4e-176 PREDICTED: breast cancer type 2 susceptibility protein homolog isoform X1 [Tribolium castaneum]>gi|642915279|ref|XP_008190553.1| PREDICTED: breast cancer type 2 susceptibility protein homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K08775 BRCA2, FANCD1 breast cancer 2 susceptibility protein http://www.genome.jp/dbget-bin/www_bget?ko:K08775 P51587 780 4.6e-81 Breast cancer type 2 susceptibility protein OS=Homo sapiens GN=BRCA2 PE=1 SV=2 PF04057//PF09103 Replication factor-A protein 1, N-terminal domain//BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 GO:0000724//GO:0006260 double-strand break repair via homologous recombination//DNA replication GO:0003677 DNA binding GO:0005634 nucleus KOG4751 DNA recombinational repair protein BRCA2 Cluster-8309.44863 BP_3 9333.80 313.89 1725 189241335 XP_001809545.1 1796 6.2e-198 PREDICTED: innexin inx3 [Tribolium castaneum]>gi|270013143|gb|EFA09591.1| hypothetical protein TcasGA2_TC011709 [Tribolium castaneum] 642936310 XM_001809493.2 422 0 PREDICTED: Tribolium castaneum innexin inx3 (LOC100141896), mRNA -- -- -- -- Q9VAS7 1318 6.8e-144 Innexin inx3 OS=Drosophila melanogaster GN=Inx3 PE=1 SV=1 PF00876//PF01292//PF06662 Innexin//Prokaryotic cytochrome b561//D-glucuronyl C5-epimerase C-terminus GO:0006118//GO:0006024 obsolete electron transport//glycosaminoglycan biosynthetic process GO:0016857//GO:0009055 racemase and epimerase activity, acting on carbohydrates and derivatives//electron carrier activity GO:0005921//GO:0016021 gap junction//integral component of membrane -- -- Cluster-8309.44864 BP_3 589.44 3.59 8214 270013321 EFA09769.1 3434 0.0e+00 hypothetical protein TcasGA2_TC011910 [Tribolium castaneum] -- -- -- -- -- K15283 SLC35E1 solute carrier family 35, member E1 http://www.genome.jp/dbget-bin/www_bget?ko:K15283 Q9VR50 1070 1.9e-114 Solute carrier family 35 member E1 homolog OS=Drosophila melanogaster GN=CG14621 PE=2 SV=1 PF00892//PF09165//PF00595//PF13180 EamA-like transporter family//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006119//GO:0006118//GO:0055114//GO:0015992 oxidative phosphorylation//obsolete electron transport//oxidation-reduction process//proton transport GO:0008121//GO:0005515 ubiquinol-cytochrome-c reductase activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.44867 BP_3 616.00 10.23 3193 642935122 XP_008197897.1 4663 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 694449459 XM_009352104.1 77 2.27136e-29 PREDICTED: Pyrus x bretschneideri uncharacterized LOC103941904 (LOC103941904), partial mRNA -- -- -- -- P10079 354 7.6e-32 Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2 PF03150//PF00023 Di-haem cytochrome c peroxidase//Ankyrin repeat GO:0055114 oxidation-reduction process GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.44870 BP_3 618.02 2.63 11605 478250013 ENN70519.1 1223 1.2e-130 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 192 1.7e-12 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF02388//PF01280 FemAB family//Ribosomal protein L19e GO:0042254//GO:0009252//GO:0006412 ribosome biogenesis//peptidoglycan biosynthetic process//translation GO:0003735//GO:0016755 structural constituent of ribosome//transferase activity, transferring amino-acyl groups GO:0005840//GO:0005622 ribosome//intracellular KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.44875 BP_3 25.33 0.38 3501 642918668 XP_008191531.1 1044 2.0e-110 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum]>gi|642918670|ref|XP_008191532.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44876 BP_3 382.91 6.25 3246 751457144 XP_011183174.1 1662 4.0e-182 PREDICTED: protein will die slowly [Bactrocera cucurbitae] 585715269 XM_006825240.1 164 1.00111e-77 PREDICTED: Saccoglossus kowalevskii protein will die slowly-like (LOC100375790), mRNA K14963 WDR5, SWD3, CPS30 COMPASS component SWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K14963 Q9V3J8 1615 4.7e-178 Protein will die slowly OS=Drosophila melanogaster GN=wds PE=1 SV=1 PF07569//PF00400//PF02944 TUP1-like enhancer of split//WD domain, G-beta repeat//BESS motif GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus KOG0266 WD40 repeat-containing protein Cluster-8309.44878 BP_3 544.20 9.89 2943 642912011 XP_008199059.1 1271 8.0e-137 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80U35 742 7.2e-77 Rho guanine nucleotide exchange factor 17 OS=Mus musculus GN=Arhgef17 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.44879 BP_3 167.71 0.99 8495 642935563 XP_008198060.1 3533 0.0e+00 PREDICTED: glutamate receptor-interacting protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97879 687 4.9e-70 Glutamate receptor-interacting protein 1 OS=Rattus norvegicus GN=Grip1 PE=1 SV=1 PF13180//PF08449//PF08088//PF00595//PF00892//PF09165//PF01783 PDZ domain//UAA transporter family//Conotoxin I-superfamily//PDZ domain (Also known as DHR or GLGF)//EamA-like transporter family//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//Ribosomal L32p protein family GO:0009405//GO:0055085//GO:0006118//GO:0015992//GO:0042254//GO:0055114//GO:0006119//GO:0006412 pathogenesis//transmembrane transport//obsolete electron transport//proton transport//ribosome biogenesis//oxidation-reduction process//oxidative phosphorylation//translation GO:0003735//GO:0008121//GO:0005515 structural constituent of ribosome//ubiquinol-cytochrome-c reductase activity//protein binding GO:0016021//GO:0005840//GO:0005576//GO:0016020//GO:0015934 integral component of membrane//ribosome//extracellular region//membrane//large ribosomal subunit KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.44881 BP_3 20.03 0.46 2371 642934951 XP_008195932.1 2237 6.2e-249 PREDICTED: protein MTO1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03495 gidA, mnmG, MTO1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K03495 Q5RB71 1520 3.5e-167 Protein MTO1 homolog, mitochondrial OS=Pongo abelii GN=MTO1 PE=2 SV=1 PF05834//PF07992//PF12831//PF01134//PF00070 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase GO:0008033//GO:0055114//GO:0016117 tRNA processing//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016705 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG2311 NAD/FAD-utilizing protein possibly involved in translation Cluster-8309.44882 BP_3 53.00 1.26 2321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44883 BP_3 236.07 30.81 661 478251437 ENN71902.1 203 1.2e-13 hypothetical protein YQE_11439, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44886 BP_3 998.43 9.75 5228 642928927 XP_008195620.1 2115 1.9e-234 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 263 1.49801e-132 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 512 6.0e-50 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44890 BP_3 4.00 0.46 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44891 BP_3 298.21 4.51 3481 478250947 ENN71431.1 310 2.6e-25 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P22897 277 7.1e-23 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03791 KNOX2 domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.44893 BP_3 2222.96 18.62 6046 642917633 XP_008193409.1 5050 0.0e+00 PREDICTED: DNA topoisomerase 2 [Tribolium castaneum] 158299571 XM_319665.4 602 0 Anopheles gambiae str. PEST AGAP008917-PA (AgaP_AGAP008917) mRNA, partial cds K03164 TOP2 DNA topoisomerase II http://www.genome.jp/dbget-bin/www_bget?ko:K03164 O16140 4530 0.0e+00 DNA topoisomerase 2 OS=Bombyx mori GN=TOP2 PE=2 SV=1 PF01728//PF00204//PF00521 FtsJ-like methyltransferase//DNA gyrase B//DNA gyrase/topoisomerase IV, subunit A GO:0006265//GO:0032259 DNA topological change//methylation GO:0003677//GO:0003918//GO:0005524//GO:0008168 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding//methyltransferase activity -- -- KOG0355 DNA topoisomerase type II Cluster-8309.44896 BP_3 87.74 1.06 4270 189241229 XP_971878.2 693 1.2e-69 PREDICTED: DNA primase large subunit [Tribolium castaneum]>gi|270013987|gb|EFA10435.1| hypothetical protein TcasGA2_TC012678 [Tribolium castaneum] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 P33610 577 1.4e-57 DNA primase large subunit OS=Mus musculus GN=Prim2 PE=1 SV=1 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896 DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.449 BP_3 2.00 0.60 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4490 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44901 BP_3 50.03 0.35 7216 642920223 XP_975548.2 2644 1.2e-295 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66GS9 565 5.9e-56 Centrosomal protein of 135 kDa OS=Homo sapiens GN=CEP135 PE=1 SV=2 PF01180//PF02183//PF00170 Dihydroorotate dehydrogenase//Homeobox associated leucine zipper//bZIP transcription factor GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0043565//GO:0003700//GO:0016627 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.44903 BP_3 234.03 3.83 3235 332373230 AEE61756.1 981 3.7e-103 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NAM7 628 1.3e-63 Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog OS=Caenorhabditis elegans GN=Y105C5B.9 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.44904 BP_3 89.27 3.40 1556 546682240 ERL92201.1 2301 1.5e-256 hypothetical protein D910_09521 [Dendroctonus ponderosae] -- -- -- -- -- K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q9VA73 1884 1.4e-209 Calcium-binding mitochondrial carrier protein Aralar1 OS=Drosophila melanogaster GN=aralar1 PE=2 SV=1 PF13405//PF13833//PF00036//PF13499//PF13202 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.44905 BP_3 159.52 0.92 8673 478262704 ENN81251.1 2158 3.3e-239 hypothetical protein YQE_02345, partial [Dendroctonus ponderosae]>gi|546679053|gb|ERL89576.1| hypothetical protein D910_06941 [Dendroctonus ponderosae] 759080227 XM_011351649.1 232 4.25757e-115 PREDICTED: Cerapachys biroi uncharacterized LOC105286595 (LOC105286595), transcript variant X5, mRNA K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 P70182 1209 1.5e-130 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Mus musculus GN=Pip5k1a PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.44906 BP_3 10.87 0.34 1836 642924612 XP_008194363.1 2213 2.9e-246 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 374 2.1e-34 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.44910 BP_3 34.00 5.15 610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44911 BP_3 611.00 20.87 1703 91081999 XP_969259.1 1356 6.4e-147 PREDICTED: ribonucleoside-diphosphate reductase subunit M2 B [Tribolium castaneum]>gi|270007377|gb|EFA03825.1| hypothetical protein TcasGA2_TC013940 [Tribolium castaneum] -- -- -- -- -- K10808 RRM2 ribonucleoside-diphosphate reductase subunit M2 http://www.genome.jp/dbget-bin/www_bget?ko:K10808 P48592 1281 1.3e-139 Ribonucleoside-diphosphate reductase subunit M2 OS=Drosophila melanogaster GN=RnrS PE=1 SV=2 PF00268 Ribonucleotide reductase, small chain GO:0006144//GO:0055114//GO:0009186//GO:0006206 purine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//pyrimidine nucleobase metabolic process GO:0004748//GO:0046914 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//transition metal ion binding GO:0005971 ribonucleoside-diphosphate reductase complex KOG1567 Ribonucleotide reductase, beta subunit Cluster-8309.44912 BP_3 808.52 10.96 3848 642926029 XP_969555.3 1934 1.4e-213 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 2.80144e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 2.3e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44913 BP_3 34.56 0.58 3145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44915 BP_3 54.87 0.56 5049 642937100 XP_008198691.1 892 1.2e-92 PREDICTED: uncharacterized protein LOC659764 [Tribolium castaneum] -- -- -- -- -- K16315 GSG2 serine/threonine-protein kinase haspin http://www.genome.jp/dbget-bin/www_bget?ko:K16315 P83103 589 6.8e-59 Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster GN=Haspin PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2464 Serine/threonine kinase (haspin family) Cluster-8309.44916 BP_3 6.00 2.53 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44920 BP_3 46.60 0.51 4719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115//PF03611 SFI toxin family//PTS system sugar-specific permease component GO:0009405//GO:0009401 pathogenesis//phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.44921 BP_3 356.19 5.48 3426 237681208 NP_001153741.1 1279 1.1e-137 cleavage and polyadenylation specific factor 4, 30kDa [Tribolium castaneum]>gi|270004678|gb|EFA01126.1| hypothetical protein TcasGA2_TC010339 [Tribolium castaneum] 751792985 XM_011207858.1 143 4.98899e-66 PREDICTED: Bactrocera dorsalis cleavage and polyadenylation specificity factor subunit 4 (LOC105228160), mRNA K14404 CPSF4, YTH1 cleavage and polyadenylation specificity factor subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14404 Q9VPT8 848 4.3e-89 Cleavage and polyadenylation specificity factor subunit 4 OS=Drosophila melanogaster GN=Clp PE=1 SV=1 PF03943//PF00098//PF00642 TAP C-terminal domain//Zinc knuckle//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0051028 mRNA transport GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.44922 BP_3 24.13 0.43 2983 478260594 ENN80297.1 378 2.9e-33 hypothetical protein YQE_03290, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44924 BP_3 545.09 3.52 7757 642939202 XP_008200380.1 3580 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 462 0 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1284 2.7e-139 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF03547//PF02617//PF00002//PF02140//PF02793//PF01825 Membrane transport protein//ATP-dependent Clp protease adaptor protein ClpS//7 transmembrane receptor (Secretin family)//Galactose binding lectin domain//Hormone receptor domain//GPCR proteolysis site, GPS, motif GO:0030163//GO:0007186//GO:0055085 protein catabolic process//G-protein coupled receptor signaling pathway//transmembrane transport GO:0030246//GO:0004930 carbohydrate binding//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG4193 G protein-coupled receptors Cluster-8309.44925 BP_3 91.91 1.68 2932 546685274 ERL94801.1 378 2.8e-33 hypothetical protein D910_12075, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44926 BP_3 1121.96 7.43 7567 642939202 XP_008200380.1 3258 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 168 1.40297e-79 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1288 9.0e-140 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF03547//PF00002//PF02617//PF02140//PF02793//PF01825 Membrane transport protein//7 transmembrane receptor (Secretin family)//ATP-dependent Clp protease adaptor protein ClpS//Galactose binding lectin domain//Hormone receptor domain//GPCR proteolysis site, GPS, motif GO:0030163//GO:0055085//GO:0007186 protein catabolic process//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0030246 G-protein coupled receptor activity//carbohydrate binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.44927 BP_3 22.74 0.31 3785 768418510 XP_011549944.1 801 3.2e-82 PREDICTED: uncharacterized protein LOC105381841 [Plutella xylostella] -- -- -- -- -- -- -- -- -- P0CT40 361 1.4e-32 Transposon Tf2-9 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-9 PE=3 SV=1 PF04414 D-aminoacyl-tRNA deacylase -- -- GO:0016788//GO:0051499 hydrolase activity, acting on ester bonds//D-aminoacyl-tRNA deacylase activity -- -- -- -- Cluster-8309.44930 BP_3 944.00 12.02 4078 642926517 XP_008191989.1 2538 1.3e-283 PREDICTED: myb-binding protein 1A [Tribolium castaneum]>gi|270009066|gb|EFA05514.1| hypothetical protein TcasGA2_TC015701 [Tribolium castaneum] -- -- -- -- -- K02331 POL5, MYBBP1A DNA polymerase phi http://www.genome.jp/dbget-bin/www_bget?ko:K02331 Q6DRL5 199 9.2e-14 Myb-binding protein 1A-like protein OS=Danio rerio GN=mybbp1a PE=1 SV=1 PF02532//PF08328//PF09815//PF04931 Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//Adenylosuccinate lyase C-terminal//XK-related protein//DNA polymerase phi GO:0006260//GO:0006522//GO:0006351//GO:0006188//GO:0015979//GO:0009152//GO:0006531//GO:0006144 DNA replication//alanine metabolic process//transcription, DNA-templated//IMP biosynthetic process//photosynthesis//purine ribonucleotide biosynthetic process//aspartate metabolic process//purine nucleobase metabolic process GO:0004018//GO:0003677//GO:0003887 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity//DNA binding//DNA-directed DNA polymerase activity GO:0009539//GO:0016021//GO:0042575//GO:0016020//GO:0009523 photosystem II reaction center//integral component of membrane//DNA polymerase complex//membrane//photosystem II KOG1926 Predicted regulator of rRNA gene transcription (MYB-binding protein) Cluster-8309.44932 BP_3 7.00 0.75 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44935 BP_3 993.68 69.09 985 546678378 ERL89011.1 852 1.0e-88 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 713 5.5e-74 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3936 Nitroreductases Cluster-8309.44936 BP_3 313.66 6.17 2742 91080237 XP_972872.1 1006 4.0e-106 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44939 BP_3 1035.01 11.97 4459 478257777 ENN77920.1 1102 4.8e-117 hypothetical protein YQE_05597, partial [Dendroctonus ponderosae] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q99JX7 569 1.2e-56 Nuclear RNA export factor 1 OS=Mus musculus GN=Nxf1 PE=1 SV=3 PF13855//PF02136//PF03943//PF09162 Leucine rich repeat//Nuclear transport factor 2 (NTF2) domain//TAP C-terminal domain//Tap, RNA-binding GO:0006810//GO:0006406//GO:0051028 transport//mRNA export from nucleus//mRNA transport GO:0003723//GO:0005515 RNA binding//protein binding GO:0005634//GO:0005622//GO:0005737 nucleus//intracellular//cytoplasm -- -- Cluster-8309.44941 BP_3 114.66 1.24 4743 478257777 ENN77920.1 1042 4.6e-110 hypothetical protein YQE_05597, partial [Dendroctonus ponderosae] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q9U1H9 529 5.8e-52 Nuclear RNA export factor 1 OS=Drosophila melanogaster GN=sbr PE=1 SV=2 PF13855//PF02136//PF03943//PF09162 Leucine rich repeat//Nuclear transport factor 2 (NTF2) domain//TAP C-terminal domain//Tap, RNA-binding GO:0051028//GO:0006810//GO:0006406 mRNA transport//transport//mRNA export from nucleus GO:0005515//GO:0003723 protein binding//RNA binding GO:0005634//GO:0005737//GO:0005622 nucleus//cytoplasm//intracellular -- -- Cluster-8309.44942 BP_3 18.16 0.32 3021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44943 BP_3 1611.09 15.09 5437 642937294 XP_008198774.1 3084 0.0e+00 PREDICTED: uncharacterized protein LOC658848 isoform X2 [Tribolium castaneum] 642937293 XM_008200552.1 244 5.68455e-122 PREDICTED: Tribolium castaneum uncharacterized LOC658848 (LOC658848), transcript variant X2, mRNA -- -- -- -- Q70EL1 976 9.7e-104 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Homo sapiens GN=USP54 PE=1 SV=4 PF00126 Bacterial regulatory helix-turn-helix protein, lysR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1887 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.44944 BP_3 250.27 4.38 3045 357622566 EHJ73993.1 2320 1.9e-258 fanconi anemia group J protein [Danaus plexippus] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 2051 1.2e-228 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 PF13307//PF00270//PF02562//PF04851//PF06733//PF00176 Helicase C-terminal domain//DEAD/DEAH box helicase//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD_2//SNF2 family N-terminal domain GO:0006139 nucleobase-containing compound metabolic process GO:0003677//GO:0016787//GO:0005524//GO:0008026//GO:0003676//GO:0004003//GO:0016818 DNA binding//hydrolase activity//ATP binding//ATP-dependent helicase activity//nucleic acid binding//ATP-dependent DNA helicase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005657 replication fork KOG1132 Helicase of the DEAD superfamily Cluster-8309.44946 BP_3 4.97 0.36 949 270006398 EFA02846.1 499 8.5e-48 regulator of telomere elongation helicase 1 [Tribolium castaneum] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 258 3.1e-21 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1132 Helicase of the DEAD superfamily Cluster-8309.44948 BP_3 40.88 1.12 2055 307197059 EFN78431.1 161 2.9e-08 Transposable element Tc3 transposase, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44949 BP_3 36.88 0.31 5938 270014063 EFA10511.1 2208 3.6e-245 hypothetical protein TcasGA2_TC012762 [Tribolium castaneum] 837785995 XM_012926268.1 41 4.36817e-09 PREDICTED: Ochotona princeps formin-like 2 (FMNL2), transcript variant X2, mRNA -- -- -- -- Q9VUC6 1601 3.6e-176 Formin-like protein CG32138 OS=Drosophila melanogaster GN=CG32138 PE=1 SV=3 PF07926//PF04627//PF06371//PF01044//PF05130//PF04632//PF03449//PF02734//PF04111//PF08671//PF06367 TPR/MLP1/MLP2-like protein//Mitochondrial ATP synthase epsilon chain//Diaphanous GTPase-binding Domain//Vinculin family//FlgN protein//Fusaric acid resistance protein family//Transcription elongation factor, N-terminal//DAK2 domain//Autophagy protein Apg6//Anti-repressor SinI//Diaphanous FH3 Domain GO:0046486//GO:0030036//GO:0006071//GO:0015992//GO:0006606//GO:0006355//GO:0006810//GO:0032784//GO:0006914//GO:0044780//GO:0015986//GO:0007155//GO:0016043//GO:0006119 glycerolipid metabolic process//actin cytoskeleton organization//glycerol metabolic process//proton transport//protein import into nucleus//regulation of transcription, DNA-templated//transport//regulation of DNA-templated transcription, elongation//autophagy//bacterial-type flagellum assembly//ATP synthesis coupled proton transport//cell adhesion//cellular component organization//oxidative phosphorylation GO:0046961//GO:0046933//GO:0051015//GO:0003779//GO:0004371//GO:0017048//GO:0046983//GO:0003677 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism//actin filament binding//actin binding//glycerone kinase activity//Rho GTPase binding//protein dimerization activity//DNA binding GO:0045259//GO:0000275//GO:0005886 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//plasma membrane KOG1923 Rac1 GTPase effector FRL Cluster-8309.44951 BP_3 5.06 0.58 715 642917177 XP_008191151.1 324 1.2e-27 PREDICTED: pangolin isoform X3 [Tribolium castaneum] 645018735 XM_008212558.1 62 1.06877e-21 PREDICTED: Nasonia vitripennis protein pangolin, isoforms A/H/I/S (LOC100120687), mRNA -- -- -- -- P91943 147 1.7e-08 Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44954 BP_3 1419.32 13.38 5404 642918478 XP_008191493.1 5390 0.0e+00 PREDICTED: epidermal growth factor receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K04361 EGFR, ERBB1 epidermal growth factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04361 P0CY46 4398 0.0e+00 Epidermal growth factor receptor OS=Apis mellifera GN=Egfr PE=2 SV=1 PF00757//PF00069//PF06293//PF07714 Furin-like cysteine rich region//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0016773//GO:0004714//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//transmembrane receptor protein tyrosine kinase activity//protein kinase activity GO:0016020 membrane KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-8309.44955 BP_3 2964.76 28.54 5299 642913636 XP_008201097.1 848 1.6e-87 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum]>gi|270002053|gb|EEZ98500.1| hypothetical protein TcasGA2_TC001001 [Tribolium castaneum] 642913635 XM_008202875.1 61 2.9689e-20 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC661669), mRNA -- -- -- -- Q9W596 677 4.5e-69 Microtubule-associated protein futsch OS=Drosophila melanogaster GN=futsch PE=1 SV=4 PF01825//PF02187//PF05923 GPCR proteolysis site, GPS, motif//Growth-Arrest-Specific Protein 2 Domain//APC cysteine-rich region GO:0007050//GO:0016055 cell cycle arrest//Wnt signaling pathway -- -- GO:0016020 membrane -- -- Cluster-8309.44956 BP_3 20.00 11.22 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44962 BP_3 7.39 1.14 605 642924854 XP_008194067.1 372 2.9e-33 PREDICTED: LOW QUALITY PROTEIN: protein mahjong [Tribolium castaneum] 662191784 XM_008470499.1 80 8.83545e-32 PREDICTED: Diaphorina citri protein mahjong (LOC103506118), mRNA K11789 VPRBP, DCAF1 HIV-1 Vpr-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11789 Q9W2F2 205 2.7e-15 Protein mahjong OS=Drosophila melanogaster GN=mahj PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1832 HIV-1 Vpr-binding protein Cluster-8309.44963 BP_3 106.46 1.53 3636 91077414 XP_975386.1 1918 9.3e-212 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 4.7e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF15281//PF02782//PF13414//PF06723//PF00516//PF12634 Consortin C-terminus//FGGY family of carbohydrate kinases, C-terminal domain//TPR repeat//MreB/Mbl protein//Envelope glycoprotein GP120//Inheritance of peroxisomes protein 1 GO:0005975//GO:0045033//GO:0000902//GO:0042998//GO:0006457 carbohydrate metabolic process//peroxisome inheritance//cell morphogenesis//positive regulation of Golgi to plasma membrane protein transport//protein folding GO:0051082//GO:0016773//GO:0071253//GO:0005515//GO:0005524 unfolded protein binding//phosphotransferase activity, alcohol group as acceptor//connexin binding//protein binding//ATP binding GO:0019031//GO:0005802//GO:0005780 viral envelope//trans-Golgi network//extrinsic component of intraperoxisomal membrane KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.44964 BP_3 183.23 2.43 3930 642920422 XP_008192343.1 2516 4.6e-281 PREDICTED: fasciclin-2 isoform X2 [Tribolium castaneum]>gi|225685461|emb|CAX64461.1| fasciclin-2 precursor [Tribolium castaneum]>gi|270005231|gb|EFA01679.1| hypothetical protein TcasGA2_TC007253 [Tribolium castaneum] -- -- -- -- -- K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1653 2.2e-182 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF05864//PF00041//PF07354//PF13895//PF16656 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006351//GO:0019497//GO:0007339//GO:0006144//GO:0006206//GO:0006771 transcription, DNA-templated//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//riboflavin metabolic process GO:0003677//GO:0003899//GO:0005515//GO:0003993//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//protein binding//acid phosphatase activity//metal ion binding GO:0005576//GO:0005730 extracellular region//nucleolus -- -- Cluster-8309.44966 BP_3 1005.47 13.02 4013 642934618 XP_008197739.1 2862 0.0e+00 PREDICTED: zinc finger protein 62-like [Tribolium castaneum]>gi|270013744|gb|EFA10192.1| hypothetical protein TcasGA2_TC012384 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05481 443 4.6e-42 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00096//PF07776//PF03337//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Poxvirus F12L protein//C2H2-type zinc finger GO:0016032 viral process GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.44969 BP_3 22.95 0.62 2069 91092598 XP_970550.1 423 1.2e-38 PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|642921812|ref|XP_008199330.1| PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|270006629|gb|EFA03077.1| hypothetical protein TcasGA2_TC010951 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9JLY7 284 6.5e-24 Dual specificity protein phosphatase 14 OS=Mus musculus GN=Dusp14 PE=2 SV=2 PF00782 Dual specificity phosphatase, catalytic domain GO:0006470 protein dephosphorylation GO:0008138 protein tyrosine/serine/threonine phosphatase activity -- -- KOG1718 Dual specificity phosphatase Cluster-8309.44971 BP_3 41.06 0.92 2436 642929832 XP_008195993.1 830 9.0e-86 PREDICTED: N-acylneuraminate-9-phosphatase [Tribolium castaneum] -- -- -- -- -- K01097 NANP N-acylneuraminate-9-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01097 Q8TBE9 345 6.4e-31 N-acylneuraminate-9-phosphatase OS=Homo sapiens GN=NANP PE=1 SV=1 PF04062 ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0005856//GO:0005885 cytoskeleton//Arp2/3 protein complex -- -- Cluster-8309.44972 BP_3 2255.22 19.60 5837 642916405 XP_008191009.1 3474 0.0e+00 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.5e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF00018//PF14604 IRSp53/MIM homology domain//SH3 domain//Variant SH3 domain GO:0007009 plasma membrane organization GO:0005515 protein binding -- -- -- -- Cluster-8309.44975 BP_3 38.67 1.19 1859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44976 BP_3 1250.18 23.17 2892 759001854 AJP08639.1 1866 7.9e-206 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 475 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1636 1.5e-180 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF06293//PF00069//PF03242 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Late embryogenesis abundant protein GO:0006950//GO:0006468 response to stress//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.44977 BP_3 302.39 2.60 5902 546679844 ERL90232.1 1077 5.0e-114 hypothetical protein D910_07585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 554 9.1e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF03561//PF01157//PF07228 Allantoicase repeat//Ribosomal protein L21e//Stage II sporulation protein E (SpoIIE) GO:0006144//GO:0006412//GO:0000256//GO:0042254//GO:0006807 purine nucleobase metabolic process//translation//allantoin catabolic process//ribosome biogenesis//nitrogen compound metabolic process GO:0003824//GO:0004037//GO:0003735 catalytic activity//allantoicase activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.4498 BP_3 3.00 0.36 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44981 BP_3 509.22 3.00 8479 642935640 XP_008198094.1 4502 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X3 [Tribolium castaneum] 642935647 XM_008199876.1 264 6.77006e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.5e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF13180//PF00620//PF00595 Glycolipid transfer protein (GLTP)//PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0051861//GO:0017089//GO:0005515 glycolipid binding//glycolipid transporter activity//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.44982 BP_3 74.20 0.48 7712 642935642 XP_008198095.1 2419 1.6e-269 PREDICTED: rho GTPase-activating protein 21-B isoform X4 [Tribolium castaneum] 642935647 XM_008199876.1 210 6.42185e-103 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.3e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF00620//PF00595//PF13180//PF11973//PF08718 RhoGAP domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain//NQRA C-terminal domain//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836//GO:0006118//GO:0055114 signal transduction//glycolipid transport//obsolete electron transport//oxidation-reduction process GO:0017089//GO:0005515//GO:0051861//GO:0016655 glycolipid transporter activity//protein binding//glycolipid binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.44985 BP_3 174.34 1.59 5576 91077028 XP_967318.1 1305 1.7e-140 PREDICTED: moesin/ezrin/radixin homolog 1 [Tribolium castaneum]>gi|270002017|gb|EEZ98464.1| hypothetical protein TcasGA2_TC000955 [Tribolium castaneum] -- -- -- -- -- K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 988 4.1e-105 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF00769//PF00887//PF05531//PF02911//PF00551 Ezrin/radixin/moesin family//Acyl CoA binding protein//Nucleopolyhedrovirus P10 protein//Formyl transferase, C-terminal domain//Formyl transferase GO:0009058 biosynthetic process GO:0008092//GO:0000062//GO:0016742 cytoskeletal protein binding//fatty-acyl-CoA binding//hydroxymethyl-, formyl- and related transferase activity GO:0005737//GO:0019028//GO:0019898 cytoplasm//viral capsid//extrinsic component of membrane KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.44987 BP_3 14.67 0.52 1655 91092532 XP_967540.1 960 5.2e-101 PREDICTED: ankyrin-1 [Tribolium castaneum]>gi|270006612|gb|EFA03060.1| hypothetical protein TcasGA2_TC010916 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 255 1.2e-20 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF07525//PF00023//PF13606 SOCS box//Ankyrin repeat//Ankyrin repeat GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.44991 BP_3 164.00 3.21 2751 91087957 XP_972849.1 2918 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit B [Tribolium castaneum]>gi|270011918|gb|EFA08366.1| hypothetical protein TcasGA2_TC006009 [Tribolium castaneum] 759033163 XM_011349720.1 192 2.3048e-93 PREDICTED: Cerapachys biroi eukaryotic translation initiation factor 3 subunit B (LOC105285460), mRNA K03253 EIF3B translation initiation factor 3 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K03253 Q1HDZ5 2290 2.1e-256 Eukaryotic translation initiation factor 3 subunit B OS=Bombyx mori GN=eIF3-S9 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0000166//GO:0003743//GO:0003676 nucleotide binding//translation initiation factor activity//nucleic acid binding GO:0005737//GO:0005840 cytoplasm//ribosome KOG2314 Translation initiation factor 3, subunit b (eIF-3b) Cluster-8309.44992 BP_3 21.00 1.04 1264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44994 BP_3 222.57 2.95 3930 665810054 XP_008553427.1 1656 2.4e-181 PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|665810056|ref|XP_008553428.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|751201535|ref|XP_011167836.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Solenopsis invicta]>gi|780681748|ref|XP_011697692.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Wasmannia auropunctata]>gi|795064613|ref|XP_011874023.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Vollenhovia emeryi]>gi|826425920|ref|XP_012527326.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Monomorium pharaonis] 642933469 XM_968453.3 436 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (LOC662352), mRNA K04382 PPP2C serine/threonine-protein phosphatase 2A catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04382 P62714 1626 3.0e-179 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens GN=PPP2CB PE=1 SV=1 PF09514//PF00149//PF02135//PF01086//PF09494 SSXRD motif//Calcineurin-like phosphoesterase//TAZ zinc finger//Clathrin light chain//Slx4 endonuclease GO:0006281//GO:0006886//GO:0042967//GO:0016192//GO:0006260//GO:0006355//GO:0006308 DNA repair//intracellular protein transport//acyl-carrier-protein biosynthetic process//vesicle-mediated transport//DNA replication//regulation of transcription, DNA-templated//DNA catabolic process GO:0016787//GO:0005198//GO:0017108//GO:0003712//GO:0008270//GO:0004402 hydrolase activity//structural molecule activity//5'-flap endonuclease activity//transcription cofactor activity//zinc ion binding//histone acetyltransferase activity GO:0030132//GO:0030130//GO:0005634//GO:0005667//GO:0000123//GO:0033557 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle//nucleus//transcription factor complex//histone acetyltransferase complex//Slx1-Slx4 complex KOG0371 Serine/threonine protein phosphatase 2A, catalytic subunit Cluster-8309.44995 BP_3 385.39 1.26 15000 91093435 XP_969667.1 5244 0.0e+00 PREDICTED: protein unc-13 homolog B [Tribolium castaneum] 642938496 XM_964574.2 1399 0 PREDICTED: Tribolium castaneum protein unc-13 homolog B (LOC658165), mRNA K15293 UNC13, MUNC13 protein unc-13 http://www.genome.jp/dbget-bin/www_bget?ko:K15293 O14795 3755 0.0e+00 Protein unc-13 homolog B OS=Homo sapiens GN=UNC13B PE=1 SV=2 PF12169//PF00130//PF11968//PF07065//PF03081//PF11112//PF01104//PF00889//PF00168//PF08236 DNA polymerase III subunits gamma and tau domain III//Phorbol esters/diacylglycerol binding domain (C1 domain)//Putative methyltransferase (DUF3321)//D123//Exo70 exocyst complex subunit//Pyocin activator protein PrtN//Bunyavirus non-structural protein NS-s//Elongation factor TS//C2 domain//SRI (Set2 Rpb1 interacting) domain GO:0016032//GO:0006479//GO:0006887//GO:0034968//GO:0006448//GO:0006414//GO:0006396//GO:0006554//GO:0000154//GO:0035556//GO:0007049//GO:0006260//GO:0006355 viral process//protein methylation//exocytosis//histone lysine methylation//regulation of translational elongation//translational elongation//RNA processing//lysine catabolic process//rRNA modification//intracellular signal transduction//cell cycle//DNA replication//regulation of transcription, DNA-templated GO:0003887//GO:0005515//GO:0018024//GO:0003746//GO:0016433 DNA-directed DNA polymerase activity//protein binding//histone-lysine N-methyltransferase activity//translation elongation factor activity//rRNA (adenine) methyltransferase activity GO:0000145//GO:0005694//GO:0042575//GO:0005622//GO:0005840 exocyst//chromosome//DNA polymerase complex//intracellular//ribosome KOG1011 Neurotransmitter release regulator, UNC-13 Cluster-8309.44996 BP_3 243.75 0.76 15767 91093435 XP_969667.1 5244 0.0e+00 PREDICTED: protein unc-13 homolog B [Tribolium castaneum] 642938496 XM_964574.2 1396 0 PREDICTED: Tribolium castaneum protein unc-13 homolog B (LOC658165), mRNA K15293 UNC13, MUNC13 protein unc-13 http://www.genome.jp/dbget-bin/www_bget?ko:K15293 O14795 3755 0.0e+00 Protein unc-13 homolog B OS=Homo sapiens GN=UNC13B PE=1 SV=2 PF00889//PF00168//PF08236//PF00130//PF07065//PF11968//PF03081//PF12169//PF01104//PF11112 Elongation factor TS//C2 domain//SRI (Set2 Rpb1 interacting) domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//D123//Putative methyltransferase (DUF3321)//Exo70 exocyst complex subunit//DNA polymerase III subunits gamma and tau domain III//Bunyavirus non-structural protein NS-s//Pyocin activator protein PrtN GO:0016032//GO:0006887//GO:0006479//GO:0006414//GO:0006448//GO:0034968//GO:0006355//GO:0006260//GO:0007049//GO:0000154//GO:0035556//GO:0006554//GO:0006396 viral process//exocytosis//protein methylation//translational elongation//regulation of translational elongation//histone lysine methylation//regulation of transcription, DNA-templated//DNA replication//cell cycle//rRNA modification//intracellular signal transduction//lysine catabolic process//RNA processing GO:0018024//GO:0005515//GO:0003887//GO:0003746//GO:0016433 histone-lysine N-methyltransferase activity//protein binding//DNA-directed DNA polymerase activity//translation elongation factor activity//rRNA (adenine) methyltransferase activity GO:0005694//GO:0000145//GO:0042575//GO:0005840//GO:0005622 chromosome//exocyst//DNA polymerase complex//ribosome//intracellular KOG1011 Neurotransmitter release regulator, UNC-13 Cluster-8309.44997 BP_3 376.06 2.27 8267 91093435 XP_969667.1 5865 0.0e+00 PREDICTED: protein unc-13 homolog B [Tribolium castaneum] 642938496 XM_964574.2 1530 0 PREDICTED: Tribolium castaneum protein unc-13 homolog B (LOC658165), mRNA K15293 UNC13, MUNC13 protein unc-13 http://www.genome.jp/dbget-bin/www_bget?ko:K15293 O14795 4289 0.0e+00 Protein unc-13 homolog B OS=Homo sapiens GN=UNC13B PE=1 SV=2 PF00168//PF08236//PF03310//PF01104//PF04623//PF11112//PF00130//PF11968//PF03081//PF07065//PF12169 C2 domain//SRI (Set2 Rpb1 interacting) domain//Caulimovirus DNA-binding protein//Bunyavirus non-structural protein NS-s//Adenovirus E1B protein N-terminus//Pyocin activator protein PrtN//Phorbol esters/diacylglycerol binding domain (C1 domain)//Putative methyltransferase (DUF3321)//Exo70 exocyst complex subunit//D123//DNA polymerase III subunits gamma and tau domain III GO:0006887//GO:0006479//GO:0009605//GO:0016032//GO:0006260//GO:0006355//GO:0006554//GO:0006396//GO:0007049//GO:0000154//GO:0035556//GO:0034968 exocytosis//protein methylation//response to external stimulus//viral process//DNA replication//regulation of transcription, DNA-templated//lysine catabolic process//RNA processing//cell cycle//rRNA modification//intracellular signal transduction//histone lysine methylation GO:0003677//GO:0018024//GO:0005515//GO:0003887//GO:0016433 DNA binding//histone-lysine N-methyltransferase activity//protein binding//DNA-directed DNA polymerase activity//rRNA (adenine) methyltransferase activity GO:0005694//GO:0000145//GO:0042575 chromosome//exocyst//DNA polymerase complex KOG1011 Neurotransmitter release regulator, UNC-13 Cluster-8309.44998 BP_3 515.07 1.61 15735 91093435 XP_969667.1 5244 0.0e+00 PREDICTED: protein unc-13 homolog B [Tribolium castaneum] 642938496 XM_964574.2 1396 0 PREDICTED: Tribolium castaneum protein unc-13 homolog B (LOC658165), mRNA K15293 UNC13, MUNC13 protein unc-13 http://www.genome.jp/dbget-bin/www_bget?ko:K15293 O14795 3755 0.0e+00 Protein unc-13 homolog B OS=Homo sapiens GN=UNC13B PE=1 SV=2 PF12169//PF00130//PF11968//PF07065//PF03081//PF11112//PF01104//PF00889//PF00168//PF08236 DNA polymerase III subunits gamma and tau domain III//Phorbol esters/diacylglycerol binding domain (C1 domain)//Putative methyltransferase (DUF3321)//D123//Exo70 exocyst complex subunit//Pyocin activator protein PrtN//Bunyavirus non-structural protein NS-s//Elongation factor TS//C2 domain//SRI (Set2 Rpb1 interacting) domain GO:0016032//GO:0006887//GO:0006479//GO:0006448//GO:0034968//GO:0006414//GO:0007049//GO:0000154//GO:0035556//GO:0006554//GO:0006396//GO:0006355//GO:0006260 viral process//exocytosis//protein methylation//regulation of translational elongation//histone lysine methylation//translational elongation//cell cycle//rRNA modification//intracellular signal transduction//lysine catabolic process//RNA processing//regulation of transcription, DNA-templated//DNA replication GO:0005515//GO:0003887//GO:0018024//GO:0003746//GO:0016433 protein binding//DNA-directed DNA polymerase activity//histone-lysine N-methyltransferase activity//translation elongation factor activity//rRNA (adenine) methyltransferase activity GO:0005694//GO:0000145//GO:0042575//GO:0005840//GO:0005622 chromosome//exocyst//DNA polymerase complex//ribosome//intracellular KOG1011 Neurotransmitter release regulator, UNC-13 Cluster-8309.44999 BP_3 253.01 3.61 3674 478253263 ENN73634.1 2771 1.2e-310 hypothetical protein YQE_09881, partial [Dendroctonus ponderosae] -- -- -- -- -- K00771 XYLT protein xylosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00771 Q5QQ53 2068 1.6e-230 Xylosyltransferase oxt OS=Drosophila pseudoobscura pseudoobscura GN=oxt PE=2 SV=1 PF12529//PF02485 Xylosyltransferase C terminal//Core-2/I-Branching enzyme GO:0030206//GO:0006024 chondroitin sulfate biosynthetic process//glycosaminoglycan biosynthetic process GO:0008375//GO:0030158 acetylglucosaminyltransferase activity//protein xylosyltransferase activity GO:0016020 membrane KOG0799 Branching enzyme Cluster-8309.45001 BP_3 1.00 0.95 335 642929713 XP_008195946.1 167 9.3e-10 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [Tribolium castaneum]>gi|642929715|ref|XP_008195947.1| PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [Tribolium castaneum]>gi|642929717|ref|XP_008195948.1| PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45004 BP_3 86.01 0.72 6045 91076832 XP_974636.1 3950 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 224 8.2978e-111 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 Q9Y6R4 854 1.5e-89 Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens GN=MAP3K4 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0000166//GO:0005524 protein kinase activity//nucleotide binding//ATP binding -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.45006 BP_3 336.13 3.23 5303 646710672 KDR16118.1 400 1.4e-35 hypothetical protein L798_10008 [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 383 5.5e-35 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13912//PF07776//PF01113//PF13465//PF00096//PF08533//PF00044 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Dihydrodipicolinate reductase, N-terminus//Zinc-finger double domain//Zinc finger, C2H2 type//Beta-galactosidase C-terminal domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0006012//GO:0009089//GO:0006027//GO:0009085//GO:0046486//GO:0006687//GO:0055114 galactose metabolic process//lysine biosynthetic process via diaminopimelate//glycosaminoglycan catabolic process//lysine biosynthetic process//glycerolipid metabolic process//glycosphingolipid metabolic process//oxidation-reduction process GO:0004565//GO:0008839//GO:0008270//GO:0016620//GO:0046872 beta-galactosidase activity//4-hydroxy-tetrahydrodipicolinate reductase//zinc ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//metal ion binding GO:0009341//GO:0005634 beta-galactosidase complex//nucleus -- -- Cluster-8309.45008 BP_3 222.85 2.07 5486 91082499 XP_972877.1 1497 9.2e-163 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU29 852 2.4e-89 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF04097//PF16276//PF00569//PF01256//PF06701//PF00637//PF02066//PF04121 Nup93/Nic96//Nucleophosmin C-terminal domain//Zinc finger, ZZ type//Carbohydrate kinase//Mib_herc2//Region in Clathrin and VPS//Metallothionein family 11//Nuclear pore protein 84 / 107 GO:0006886//GO:0016567//GO:0006810//GO:0016192 intracellular protein transport//protein ubiquitination//transport//vesicle-mediated transport GO:0004842//GO:0052855//GO:0005507//GO:0046872//GO:0003676//GO:0008270 ubiquitin-protein transferase activity//ADP-dependent NAD(P)H-hydrate dehydratase activity//copper ion binding//metal ion binding//nucleic acid binding//zinc ion binding GO:0005643 nuclear pore -- -- Cluster-8309.45009 BP_3 181.78 4.19 2385 110767819 XP_393546.3 2235 1.1e-248 PREDICTED: potassium voltage-gated channel protein Shab-like isoform X6 [Apis mellifera] 189008483 EU616810.1 323 3.00309e-166 Tribolium castaneum shaker cognate b (Shab) gene, exon 2 and partial cds K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1985 4.3e-221 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF02214//PF00520//PF13374 BTB/POZ domain//Ion transport protein//Tetratricopeptide repeat GO:0055085//GO:0051260//GO:0006811 transmembrane transport//protein homooligomerization//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane -- -- Cluster-8309.45010 BP_3 233.46 12.92 1163 642927612 XP_973436.3 625 2.5e-62 PREDICTED: cell growth regulator with RING finger domain protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45012 BP_3 287.12 2.17 6669 91080389 XP_966373.1 6388 0.0e+00 PREDICTED: teneurin-a, partial [Tribolium castaneum] 194768035 XM_001966084.1 267 1.14314e-134 Drosophila ananassae GF19389 (Dana\GF19389), mRNA -- -- -- -- Q9VYN8 4159 0.0e+00 Teneurin-a OS=Drosophila melanogaster GN=Ten-a PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.45016 BP_3 243.17 2.03 6078 91080389 XP_966373.1 6388 0.0e+00 PREDICTED: teneurin-a, partial [Tribolium castaneum] 194768035 XM_001966084.1 267 1.04177e-134 Drosophila ananassae GF19389 (Dana\GF19389), mRNA -- -- -- -- Q9VYN8 4159 0.0e+00 Teneurin-a OS=Drosophila melanogaster GN=Ten-a PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.45018 BP_3 1314.59 11.98 5579 642931607 XP_008196654.1 4556 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 853 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3318 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02171//PF02170//PF04810 Piwi domain//PAZ domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0008270//GO:0003676 protein binding//zinc ion binding//nucleic acid binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.45019 BP_3 138.43 4.01 1957 642916559 XP_008191693.1 1581 6.0e-173 PREDICTED: uncharacterized protein LOC103312554 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45020 BP_3 38.15 0.45 4422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45022 BP_3 17.77 0.80 1367 645020639 XP_008207241.1 180 1.2e-10 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45023 BP_3 86.13 0.86 5107 478260665 ENN80362.1 1376 9.2e-149 hypothetical protein YQE_03221, partial [Dendroctonus ponderosae]>gi|478269621|gb|ENN83368.1| hypothetical protein YQE_00276, partial [Dendroctonus ponderosae]>gi|546683697|gb|ERL93475.1| hypothetical protein D910_10766 [Dendroctonus ponderosae] -- -- -- -- -- K08592 SENP1 sentrin-specific protease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08592 Q9VXP4 724 1.5e-74 Platelet-activating factor acetylhydrolase IB subunit beta homolog OS=Drosophila melanogaster GN=Paf-AHalpha PE=1 SV=1 PF00657//PF00770//PF02902 GDSL-like Lipase/Acylhydrolase//Adenovirus endoprotease//Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0016788//GO:0008234//GO:0004197 hydrolase activity, acting on ester bonds//cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG0778 Protease, Ulp1 family Cluster-8309.45025 BP_3 10.36 1.35 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45029 BP_3 459.53 21.88 1304 332374520 AEE62401.1 597 5.0e-59 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45031 BP_3 14.49 0.74 1233 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45034 BP_3 50.78 3.29 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45037 BP_3 511.01 4.70 5534 642918693 XP_008191540.1 2619 7.3e-293 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 1276 1.6e-138 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF00788//PF15200 Ras association (RalGDS/AF-6) domain//Keratinocyte differentiation-associated GO:0007165 signal transduction -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.45038 BP_3 85.09 0.77 5641 642918693 XP_008191540.1 2619 7.5e-293 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 1276 1.7e-138 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200//PF00788 Keratinocyte differentiation-associated//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.45040 BP_3 7.39 0.34 1338 478256455 ENN76640.1 1257 1.5e-135 hypothetical protein YQE_06819, partial [Dendroctonus ponderosae]>gi|546684774|gb|ERL94369.1| hypothetical protein D910_11649, partial [Dendroctonus ponderosae] 242009899 XM_002425675.1 68 9.44417e-25 Pediculus humanus corporis heat shock protein 75 kDa, putative, mRNA K09488 TRAP1, HSP75 TNF receptor-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09488 Q9CQN1 907 2.4e-96 Heat shock protein 75 kDa, mitochondrial OS=Mus musculus GN=Trap1 PE=1 SV=1 PF00183 Hsp90 protein GO:0006457//GO:0006950 protein folding//response to stress GO:0005524//GO:0051082 ATP binding//unfolded protein binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.45041 BP_3 9691.71 152.84 3348 121583752 NP_001073568.1 1122 1.7e-119 cuticular protein analogous to peritrophins 3-D2 precursor [Tribolium castaneum]>gi|119387892|gb|ABL73931.1| obstractor D [Tribolium castaneum]>gi|270002339|gb|EEZ98786.1| hypothetical protein TcasGA2_TC001350 [Tribolium castaneum] 815806463 XM_012368582.1 219 2.75255e-108 PREDICTED: Linepithema humile chondroitin proteoglycan-2-like (LOC105673158), mRNA -- -- -- -- Q86UB9 201 4.4e-14 Transmembrane protein 135 OS=Homo sapiens GN=TMEM135 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.45042 BP_3 4186.13 66.67 3318 121583752 NP_001073568.1 1122 1.7e-119 cuticular protein analogous to peritrophins 3-D2 precursor [Tribolium castaneum]>gi|119387892|gb|ABL73931.1| obstractor D [Tribolium castaneum]>gi|270002339|gb|EEZ98786.1| hypothetical protein TcasGA2_TC001350 [Tribolium castaneum] 815806463 XM_012368582.1 219 2.72762e-108 PREDICTED: Linepithema humile chondroitin proteoglycan-2-like (LOC105673158), mRNA -- -- -- -- Q86UB9 201 4.4e-14 Transmembrane protein 135 OS=Homo sapiens GN=TMEM135 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.45043 BP_3 246.43 1.31 9369 642921537 XP_967662.3 1215 7.9e-130 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270006324|gb|EFA02772.1| hypothetical protein TcasGA2_TC008507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWF2 488 6.5e-47 Supporter of activation of yellow protein OS=Drosophila melanogaster GN=e(y)3 PE=2 SV=3 -- -- -- -- GO:0003677 DNA binding -- -- KOG1512 PHD Zn-finger protein Cluster-8309.45044 BP_3 1177.40 8.77 6760 546681968 ERL91964.1 676 1.8e-67 hypothetical protein D910_09287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 139 1.4e-06 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF09472//PF04838 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Baculoviridae late expression factor 5 GO:0015948//GO:0006355//GO:0046656 methanogenesis//regulation of transcription, DNA-templated//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane -- -- Cluster-8309.45045 BP_3 200.57 1.39 7236 642921537 XP_967662.3 1215 6.1e-130 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270006324|gb|EFA02772.1| hypothetical protein TcasGA2_TC008507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWF2 488 5.0e-47 Supporter of activation of yellow protein OS=Drosophila melanogaster GN=e(y)3 PE=2 SV=3 -- -- -- -- GO:0003677 DNA binding -- -- KOG1512 PHD Zn-finger protein Cluster-8309.45046 BP_3 15.00 0.91 1090 478252983 ENN73365.1 591 2.1e-58 hypothetical protein YQE_10015, partial [Dendroctonus ponderosae]>gi|546679350|gb|ERL89825.1| hypothetical protein D910_07185 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P51909 223 4.0e-17 Apolipoprotein D OS=Cavia porcellus GN=APOD PE=2 SV=1 PF03973 Triabin GO:0030682 evasion or tolerance of host defense response -- -- -- -- -- -- Cluster-8309.45048 BP_3 150.00 6.93 1335 768437701 XP_011560403.1 311 7.5e-26 PREDICTED: zinc finger protein Xfin-like [Plutella xylostella]>gi|768437703|ref|XP_011560404.1| PREDICTED: zinc finger protein Xfin-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q9W747 217 2.4e-16 Zinc finger protein draculin OS=Danio rerio GN=drl PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.45049 BP_3 258.98 2.90 4589 546684929 ERL94511.1 246 8.9e-18 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF01363 Zinc-finger associated domain (zf-AD)//FYVE zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45050 BP_3 17.02 1.71 771 546684929 ERL94511.1 201 2.5e-13 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF17123 Zinc-finger associated domain (zf-AD)//RING-like zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45052 BP_3 128.24 2.03 3340 642923250 XP_008193676.1 367 6.0e-32 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 313 4.5e-27 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF14634//PF00097//PF00569//PF06701//PF15898//PF13639//PF07663 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc finger, ZZ type//Mib_herc2//cGMP-dependent protein kinase interacting domain//Ring finger domain//Sorbitol phosphotransferase enzyme II C-terminus GO:0016567//GO:0009401//GO:0008643 protein ubiquitination//phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport GO:0004842//GO:0005515//GO:0008270//GO:0019901//GO:0008982//GO:0046872 ubiquitin-protein transferase activity//protein binding//zinc ion binding//protein kinase binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//metal ion binding GO:0016021//GO:0009357 integral component of membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger Cluster-8309.45053 BP_3 166.49 9.55 1132 642923250 XP_008193676.1 243 4.9e-18 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q96AX9 202 1.1e-14 E3 ubiquitin-protein ligase MIB2 OS=Homo sapiens GN=MIB2 PE=1 SV=3 PF06701//PF13639//PF14634//PF00097 Mib_herc2//Ring finger domain//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0005515//GO:0046872//GO:0004842//GO:0008270 protein binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding -- -- -- -- Cluster-8309.45055 BP_3 62.04 11.76 546 478260276 ENN80028.1 197 5.1e-13 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q99KE8 133 5.5e-07 Zinc finger protein 64 OS=Mus musculus GN=Zfp64 PE=2 SV=1 PF00096//PF13465//PF04988//PF02150//PF07649 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//RNA polymerases M/15 Kd subunit//C1-like domain GO:0006206//GO:0055114//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process GO:0047134//GO:0046872//GO:0003899//GO:0003677 protein-disulfide reductase activity//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.45057 BP_3 86.38 4.23 1277 642937652 XP_966876.3 224 8.8e-16 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 145 5.2e-08 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF16866//PF07649//PF06397//PF02150//PF04988//PF00096//PF13465 PHD-finger//C1-like domain//Desulfoferrodoxin, N-terminal domain//RNA polymerases M/15 Kd subunit//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006351//GO:0006144//GO:0006206//GO:0055114 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0003899//GO:0003677//GO:0005515//GO:0046872//GO:0047134//GO:0005506 DNA-directed RNA polymerase activity//DNA binding//protein binding//metal ion binding//protein-disulfide reductase activity//iron ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.45058 BP_3 673.64 5.92 5775 780110017 XP_011676369.1 240 5.6e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 207 1.5e-14 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF07776//PF00023//PF06213//PF13606 Zinc-finger associated domain (zf-AD)//Ankyrin repeat//Cobalamin biosynthesis protein CobT//Ankyrin repeat GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.45059 BP_3 278.79 2.09 6733 795370015 XP_011748985.1 261 2.4e-19 PREDICTED: neurofilament heavy polypeptide isoform X4 [Macaca nemestrina]>gi|795370020|ref|XP_011748986.1| PREDICTED: neurofilament heavy polypeptide isoform X5 [Macaca nemestrina]>gi|795370026|ref|XP_011748987.1| PREDICTED: neurofilament heavy polypeptide isoform X6 [Macaca nemestrina] -- -- -- -- -- -- -- -- -- P12036 226 1.1e-16 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.45060 BP_3 2904.60 36.90 4086 642927788 XP_008195406.1 2047 1.2e-226 PREDICTED: pre-mRNA-processing factor 39 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13217 PRPF39, PRP39 pre-mRNA-processing factor 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13217 Q1JPZ7 1005 3.2e-107 Pre-mRNA-processing factor 39 OS=Danio rerio GN=prpf39 PE=2 SV=2 PF13414//PF13174//PF02978//PF13181//PF00515//PF02184 TPR repeat//Tetratricopeptide repeat//Signal peptide binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//HAT (Half-A-TPR) repeat GO:0006614//GO:0006396 SRP-dependent cotranslational protein targeting to membrane//RNA processing GO:0008312//GO:0005515 7S RNA binding//protein binding GO:0005622//GO:0048500 intracellular//signal recognition particle KOG1258 mRNA processing protein Cluster-8309.45064 BP_3 10.77 1.04 793 91078850 XP_971848.1 674 3.6e-68 PREDICTED: uncharacterized protein LOC660531 [Tribolium castaneum]>gi|270004130|gb|EFA00578.1| hypothetical protein TcasGA2_TC003448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0042318 penicillin biosynthetic process -- -- -- -- -- -- Cluster-8309.45066 BP_3 1090.99 8.79 6275 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.28325e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.2e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF01929//PF00787//PF00018//PF00620//PF14604 Ribosomal protein L14//PX domain//SH3 domain//RhoGAP domain//Variant SH3 domain GO:0007165//GO:0006412//GO:0042254//GO:0007154 signal transduction//translation//ribosome biogenesis//cell communication GO:0035091//GO:0005515//GO:0003735 phosphatidylinositol binding//protein binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.45068 BP_3 437.77 1.92 11310 642937629 XP_008198876.1 4353 0.0e+00 PREDICTED: tubby-related protein 4 [Tribolium castaneum] 462288762 APGK01055065.1 72 4.87976e-26 Dendroctonus ponderosae Seq01055075, whole genome shotgun sequence -- -- -- -- Q9JIL5 1348 1.5e-146 Tubby-related protein 4 OS=Mus musculus GN=Tulp4 PE=2 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- KOG2503 Tubby superfamily protein TULP4 Cluster-8309.45069 BP_3 1850.72 23.72 4052 189235221 XP_967494.2 2057 7.9e-228 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15047 HNRNPUL1, E1BAP5 heterogeneous nuclear ribonucleoprotein U-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15047 Q8VDM6 770 5.6e-80 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Mus musculus GN=Hnrnpul1 PE=1 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.4507 BP_3 51.00 0.86 3152 91087147 XP_975307.1 1067 3.9e-113 PREDICTED: uncharacterized protein LOC664201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45072 BP_3 374.48 4.03 4765 642919813 XP_008192079.1 4713 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X4 [Tribolium castaneum] 642919812 XM_008193857.1 759 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X4, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1895 2.3e-210 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF05445//PF00069//PF06293//PF07714 Poxvirus serine/threonine protein kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.45073 BP_3 46.16 0.31 7384 270005401 EFA01849.1 4351 0.0e+00 hypothetical protein TcasGA2_TC007452 [Tribolium castaneum] 768422702 XM_011553921.1 458 0 PREDICTED: Plutella xylostella homeodomain-interacting protein kinase 2-like (LOC105383806), mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1823 8.1e-202 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF07714//PF06293//PF00069//PF05445 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.45076 BP_3 1012.36 10.38 4994 91076832 XP_974636.1 4089 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 224 6.84648e-111 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 Q9Y6R4 854 1.3e-89 Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens GN=MAP3K4 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0000166//GO:0004672 ATP binding//nucleotide binding//protein kinase activity -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.45077 BP_3 1859.57 17.68 5361 642918693 XP_008191540.1 2619 7.1e-293 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 1276 1.6e-138 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200//PF00788 Keratinocyte differentiation-associated//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.45078 BP_3 52.16 2.88 1166 642923532 XP_969777.2 291 1.4e-23 PREDICTED: GPALPP motifs-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IXQ4 171 4.6e-11 GPALPP motifs-containing protein 1 OS=Homo sapiens GN=GPALPP1 PE=1 SV=1 PF06638//PF06687 Strabismus protein//SUR7/PalI family GO:0007275 multicellular organismal development -- -- GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.4508 BP_3 20.00 0.55 2048 357622005 EHJ73629.1 489 2.6e-46 hypothetical protein KGM_22172 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF03184 helix-turn-helix, Psq domain//DDE superfamily endonuclease -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.45082 BP_3 184.06 4.18 2415 91092388 XP_968476.1 2123 1.0e-235 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 1.0382e-21 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45083 BP_3 1202.15 26.12 2510 478254210 ENN74475.1 2197 2.9e-244 hypothetical protein YQE_08921, partial [Dendroctonus ponderosae] -- -- -- -- -- K02085 APC adenomatosis polyposis coli protein http://www.genome.jp/dbget-bin/www_bget?ko:K02085 Q61315 1246 2.2e-135 Adenomatous polyposis coli protein OS=Mus musculus GN=Apc PE=1 SV=1 PF02985//PF05972//PF00514//PF10280 HEAT repeat//APC 15 residue motif//Armadillo/beta-catenin-like repeat//Mediator complex protein GO:0006357//GO:0016055 regulation of transcription from RNA polymerase II promoter//Wnt signaling pathway GO:0008013//GO:0001104//GO:0005515 beta-catenin binding//RNA polymerase II transcription cofactor activity//protein binding GO:0016592//GO:0016342 mediator complex//catenin complex KOG2122 Beta-catenin-binding protein APC, contains ARM repeats Cluster-8309.45084 BP_3 222.97 11.10 1260 189240236 XP_001811057.1 1774 1.6e-195 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 54 5.38161e-17 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q7ZYD5 1064 1.4e-114 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Xenopus laevis GN=slc25a25 PE=2 SV=1 PF13202//PF13499//PF10591//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0036 Predicted mitochondrial carrier protein Cluster-8309.45085 BP_3 16.61 0.41 2240 642912719 XP_008200974.1 337 1.2e-28 PREDICTED: tyrosine kinase receptor Cad96Ca isoform X1 [Tribolium castaneum] -- -- -- -- -- K08252 E2.7.10.1 receptor protein-tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08252 Q9VBW3 180 8.0e-12 Tyrosine kinase receptor Cad96Ca OS=Drosophila melanogaster GN=Cad96Ca PE=2 SV=2 PF16622//PF00028 zinc-finger C2H2-type//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0046872 calcium ion binding//metal ion binding GO:0016020 membrane -- -- Cluster-8309.45088 BP_3 401.35 10.76 2090 478254798 ENN75034.1 1459 9.0e-159 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 170 2.96172e-81 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 980 1.3e-104 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.45089 BP_3 157.60 0.59 13108 189235004 XP_970036.2 3148 0.0e+00 PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [Tribolium castaneum]>gi|270003924|gb|EFA00372.1| hypothetical protein TcasGA2_TC003215 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 Q6IR34 1563 2.0e-171 G-protein-signaling modulator 1 OS=Mus musculus GN=Gpsm1 PE=1 SV=3 PF05194//PF00069//PF07714//PF13181//PF10579//PF13414//PF02104//PF13176//PF00620//PF02188//PF06293//PF04692//PF13374//PF00515 UreE urease accessory protein, C-terminal domain//Protein kinase domain//Protein tyrosine kinase//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//TPR repeat//SURF1 family//Tetratricopeptide repeat//RhoGAP domain//GoLoco motif//Lipopolysaccharide kinase (Kdo/WaaP) family//Platelet-derived growth factor, N terminal region//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0007165//GO:0006461//GO:0007268//GO:0006468//GO:0040007//GO:0008283//GO:0019627 signal transduction//protein complex assembly//synaptic transmission//protein phosphorylation//growth//cell proliferation//urea metabolic process GO:0005524//GO:0030695//GO:0016773//GO:0004672//GO:0043495//GO:0008083//GO:0033130//GO:0005515//GO:0016151 ATP binding//GTPase regulator activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein anchor//growth factor activity//acetylcholine receptor binding//protein binding//nickel cation binding GO:0016020 membrane KOG1563 Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase Cluster-8309.45090 BP_3 59.07 0.93 3349 642925753 XP_008201610.1 903 4.3e-94 PREDICTED: protein GUCD1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 1.4e-39 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284//PF03412 Cytochrome c oxidase subunit Va//Peptidase C39 family GO:0006123//GO:0015992//GO:0006508 mitochondrial electron transport, cytochrome c to oxygen//proton transport//proteolysis GO:0005524//GO:0004129//GO:0008233 ATP binding//cytochrome-c oxidase activity//peptidase activity GO:0045277//GO:0016021//GO:0005743 respiratory chain complex IV//integral component of membrane//mitochondrial inner membrane KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.45091 BP_3 37.00 43.70 322 642922463 XP_008193182.1 277 1.6e-22 PREDICTED: integrin beta-PS [Tribolium castaneum] -- -- -- -- -- K06493 ITGB3 integrin beta 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06493 P11584 223 1.2e-17 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.45092 BP_3 237.43 10.12 1423 642919702 XP_008192028.1 994 5.1e-105 PREDICTED: inositol-trisphosphate 3-kinase A-like [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 638 4.0e-65 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.45097 BP_3 332.18 5.05 3464 91091214 XP_966756.1 2881 0.0e+00 PREDICTED: WD repeat-containing protein 24 [Tribolium castaneum]>gi|270014105|gb|EFA10553.1| hypothetical protein TcasGA2_TC012809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZX22 1413 1.3e-154 WD repeat-containing protein 24 OS=Xenopus laevis GN=wdr24 PE=2 SV=1 PF00400 WD domain, G-beta repeat GO:0007165//GO:0016558 signal transduction//protein import into peroxisome matrix GO:0005053//GO:0005515 peroxisome matrix targeting signal-2 binding//protein binding GO:0005777//GO:0005781 peroxisome//obsolete peroxisome targeting signal receptor complex KOG0269 WD40 repeat-containing protein Cluster-8309.45098 BP_3 542.05 20.88 1543 546673667 ERL85231.1 1312 7.3e-142 hypothetical protein D910_02652 [Dendroctonus ponderosae] -- -- -- -- -- K06990 K06990 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06990 Q803S3 958 3.4e-102 Protein MEMO1 OS=Danio rerio GN=memo1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3086 Predicted dioxygenase Cluster-8309.45099 BP_3 527.08 4.05 6568 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028//PF14249 Cadherin domain//Tocopherol cyclase GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0009976//GO:0005509 tocopherol cyclase activity//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.45100 BP_3 187.00 5.54 1919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07657 N terminus of Notch ligand GO:0007219//GO:0007275 Notch signaling pathway//multicellular organismal development -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45101 BP_3 386.79 9.45 2264 478256359 ENN76549.1 2315 5.3e-258 hypothetical protein YQE_07000, partial [Dendroctonus ponderosae]>gi|546680788|gb|ERL90994.1| hypothetical protein D910_08336 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 274 1.0e-22 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45104 BP_3 321.44 3.73 4440 270006116 EFA02564.1 933 1.9e-97 hypothetical protein TcasGA2_TC008273 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q7ZYQ3 470 3.8e-45 Choline/ethanolaminephosphotransferase 1 OS=Xenopus laevis GN=cept1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.45105 BP_3 159.00 2.40 3482 642920784 XP_008192559.1 186 6.1e-11 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00871 Acetokinase family GO:0008152//GO:0016310 metabolic process//phosphorylation GO:0016774//GO:0016301 phosphotransferase activity, carboxyl group as acceptor//kinase activity GO:0005622 intracellular -- -- Cluster-8309.45107 BP_3 384.54 3.12 6239 270006116 EFA02564.1 908 2.1e-94 hypothetical protein TcasGA2_TC008273 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q7ZYQ3 470 5.3e-45 Choline/ethanolaminephosphotransferase 1 OS=Xenopus laevis GN=cept1 PE=2 SV=1 PF01066 CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0016780 phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.45108 BP_3 84.36 7.42 840 642920788 XP_008192561.1 234 4.0e-17 PREDICTED: cholinephosphotransferase 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45109 BP_3 34.36 0.40 4417 270006116 EFA02564.1 251 2.3e-18 hypothetical protein TcasGA2_TC008273 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q7ZYQ3 157 7.4e-09 Choline/ethanolaminephosphotransferase 1 OS=Xenopus laevis GN=cept1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.45110 BP_3 781.75 19.39 2235 642911471 XP_008199437.1 1821 1.0e-200 PREDICTED: LOW QUALITY PROTEIN: dihydropyrimidinase [Tribolium castaneum] 762124057 XM_011446728.1 87 4.37119e-35 PREDICTED: Crassostrea gigas dihydropyrimidinase-like (LOC105340590), transcript variant X7, mRNA K01464 DPYS, dht, hydA dihydropyrimidinase http://www.genome.jp/dbget-bin/www_bget?ko:K01464 Q63150 1134 1.9e-122 Dihydropyrimidinase OS=Rattus norvegicus GN=Dpys PE=1 SV=2 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG2584 Dihydroorotase and related enzymes Cluster-8309.45111 BP_3 143.83 5.80 1487 478262463 ENN81134.1 908 5.0e-95 hypothetical protein YQE_02502, partial [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q06AU5 721 9.9e-75 Ras-related protein Rab-32 OS=Sus scrofa GN=RAB32 PE=2 SV=1 PF04670//PF10662//PF00071//PF00503//PF02367//PF00025//PF01926//PF08477 Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//G-protein alpha subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0006576//GO:0007186//GO:0002949//GO:0007264 signal transduction//cellular biogenic amine metabolic process//G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0031683//GO:0005524//GO:0003924//GO:0004871//GO:0019001//GO:0005525 G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//signal transducer activity//guanyl nucleotide binding//GTP binding -- -- KOG0394 Ras-related GTPase Cluster-8309.45112 BP_3 56.61 0.81 3651 478262463 ENN81134.1 1181 2.7e-126 hypothetical protein YQE_02502, partial [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q06AU5 724 1.1e-74 Ras-related protein Rab-32 OS=Sus scrofa GN=RAB32 PE=2 SV=1 PF01926//PF08477//PF00025//PF15168//PF02367//PF04670//PF10662//PF00071 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Triple QxxK/R motif-containing protein family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family GO:0002949//GO:0006576//GO:0007264 tRNA threonylcarbamoyladenosine modification//cellular biogenic amine metabolic process//small GTPase mediated signal transduction GO:0005524//GO:0005525 ATP binding//GTP binding GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.45113 BP_3 13.00 1.62 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45115 BP_3 35.73 0.47 3991 795018312 XP_011859165.1 573 9.3e-56 PREDICTED: uncharacterized protein LOC105556682 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45117 BP_3 3.00 0.95 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04689 DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.45118 BP_3 104.96 1.12 4824 642921287 XP_008192801.1 4438 0.0e+00 PREDICTED: disheveled-associated activator of morphogenesis 1 isoform X1 [Tribolium castaneum] 642921292 XM_008194582.1 488 0 PREDICTED: Tribolium castaneum disheveled-associated activator of morphogenesis 1 (LOC658864), transcript variant X4, mRNA K04512 DAAM dishevelled associated activator of morphogenesis http://www.genome.jp/dbget-bin/www_bget?ko:K04512 Q8BPM0 1369 2.3e-149 Disheveled-associated activator of morphogenesis 1 OS=Mus musculus GN=Daam1 PE=1 SV=4 PF06367//PF06371//PF04561//PF01763 Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain//RNA polymerase Rpb2, domain 2//Herpesvirus UL6 like GO:0016043//GO:0006144//GO:0006351//GO:0030036//GO:0006323//GO:0006206 cellular component organization//purine nucleobase metabolic process//transcription, DNA-templated//actin cytoskeleton organization//DNA packaging//pyrimidine nucleobase metabolic process GO:0003779//GO:0003677//GO:0003899//GO:0017048 actin binding//DNA binding//DNA-directed RNA polymerase activity//Rho GTPase binding GO:0005730 nucleolus KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.45119 BP_3 70.84 0.46 7731 546674242 ERL85667.1 1294 4.5e-139 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q6DD32 793 2.3e-82 RING finger protein 121 OS=Xenopus laevis GN=rnf121 PE=2 SV=1 PF00097//PF17123//PF12678//PF14634//PF12861//PF13639//PF07967 Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//C3HC zinc finger-like GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//metal ion binding//protein binding//zinc ion binding GO:0005680//GO:0005634 anaphase-promoting complex//nucleus KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.4512 BP_3 10.00 0.86 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45122 BP_3 1.00 0.51 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45123 BP_3 172.59 0.79 10767 270003171 EEZ99618.1 1776 8.1e-195 hypothetical protein TcasGA2_TC002136 [Tribolium castaneum] 795019206 XM_012004108.1 296 1.39973e-150 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556990 (LOC105556990), mRNA K09585 TXNDC10 thioredoxin domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09585 Q9VPF8 987 1.0e-104 Transmembrane protein 104 homolog OS=Drosophila melanogaster GN=CG5262 PE=2 SV=2 PF00400//PF01428//PF03222//PF01984//PF01216//PF00659//PF00578//PF02073//PF00085 WD domain, G-beta repeat//AN1-like Zinc finger//Tryptophan/tyrosine permease family//Double-stranded DNA-binding domain//Calsequestrin//POLO box duplicated region//AhpC/TSA family//Thermophilic metalloprotease (M29)//Thioredoxin GO:0055114//GO:0045454//GO:0003333//GO:0006508 oxidation-reduction process//cell redox homeostasis//amino acid transmembrane transport//proteolysis GO:0016491//GO:0005515//GO:0003677//GO:0016209//GO:0005509//GO:0008270//GO:0004177 oxidoreductase activity//protein binding//DNA binding//antioxidant activity//calcium ion binding//zinc ion binding//aminopeptidase activity -- -- KOG4277 Uncharacterized conserved protein, contains thioredoxin domain Cluster-8309.45124 BP_3 430.60 4.36 5052 270000843 EEZ97290.1 2313 2.0e-257 hypothetical protein TcasGA2_TC011095 [Tribolium castaneum] 642937273 XM_008200545.1 377 0 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X2, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 1079 1.0e-115 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.45125 BP_3 957.74 11.46 4320 270000843 EEZ97290.1 2031 8.7e-225 hypothetical protein TcasGA2_TC011095 [Tribolium castaneum] 642937273 XM_008200545.1 377 0 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X2, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 1079 8.8e-116 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF00595//PF16867//PF13180//PF01369 PDZ domain (Also known as DHR or GLGF)//Dimethlysulfonioproprionate lyase//PDZ domain//Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086//GO:0005515//GO:0047869 ARF guanyl-nucleotide exchange factor activity//protein binding//dimethylpropiothetin dethiomethylase activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.45126 BP_3 1035.46 251.45 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45127 BP_3 104.07 0.63 8196 642927844 XP_008195423.1 1169 1.5e-124 PREDICTED: INO80 complex subunit D-B-like [Tribolium castaneum]>gi|270010242|gb|EFA06690.1| hypothetical protein TcasGA2_TC009621 [Tribolium castaneum] -- -- -- -- -- K11668 INO80D INO80 complex subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K11668 Q66JY2 239 4.2e-18 INO80 complex subunit D OS=Mus musculus GN=Ino80d PE=2 SV=3 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45128 BP_3 183.39 7.64 1449 642926052 XP_970129.2 648 6.8e-65 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41034 207 3.8e-15 Alpha-tocopherol transfer protein OS=Rattus norvegicus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45129 BP_3 377.92 2.34 8074 642938555 XP_008199840.1 3495 0.0e+00 PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum]>gi|642938557|ref|XP_008199841.1| PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum] 642938558 XR_511746.1 676 0 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X3, misc_RNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 6.6e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF02985//PF08935//PF01312//PF01602//PF09258//PF00514 HEAT repeat//Viral protein VP4 subunit//FlhB HrpN YscU SpaS Family//Adaptin N terminal region//Glycosyl transferase family 64 domain//Armadillo/beta-catenin-like repeat GO:0015012//GO:0016192//GO:0006886//GO:0006024//GO:0009306 heparan sulfate proteoglycan biosynthetic process//vesicle-mediated transport//intracellular protein transport//glycosaminoglycan biosynthetic process//protein secretion GO:0005515 protein binding GO:0019030//GO:0016021//GO:0016020//GO:0030117 icosahedral viral capsid//integral component of membrane//membrane//membrane coat KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins Cluster-8309.45131 BP_3 368.83 1.91 9609 642930211 XP_008196303.1 2319 7.8e-258 PREDICTED: protein aubergine [Tribolium castaneum]>gi|642930213|ref|XP_008196304.1| PREDICTED: protein aubergine [Tribolium castaneum]>gi|270010977|gb|EFA07425.1| piwi [Tribolium castaneum] 820846169 XM_003692874.2 149 6.50575e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 1447 4.2e-158 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF02230//PF02171//PF04636//PF07859//PF09494//PF15384//PF01764//PF02170//PF02186 Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin)//alpha/beta hydrolase fold//Slx4 endonuclease//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//Lipase (class 3)//PAZ domain//TFIIE beta subunit core domain GO:0006281//GO:0006629//GO:0006303//GO:0008152//GO:0006308//GO:0006367//GO:1901031//GO:0006260 DNA repair//lipid metabolic process//double-strand break repair via nonhomologous end joining//metabolic process//DNA catabolic process//transcription initiation from RNA polymerase II promoter//regulation of response to reactive oxygen species//DNA replication GO:0017108//GO:0005515//GO:0016787//GO:0003676 5'-flap endonuclease activity//protein binding//hydrolase activity//nucleic acid binding GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.45132 BP_3 11.85 0.64 1186 642919843 XP_008192092.1 744 4.1e-76 PREDICTED: TIP41-like protein [Tribolium castaneum]>gi|270005393|gb|EFA01841.1| hypothetical protein TcasGA2_TC007443 [Tribolium castaneum] -- -- -- -- -- K17607 TIPRL, TIP41 type 2A phosphatase activator TIP41 http://www.genome.jp/dbget-bin/www_bget?ko:K17607 Q6IRA8 382 1.6e-35 TIP41-like protein OS=Xenopus laevis GN=tiprl PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3224 Uncharacterized conserved protein Cluster-8309.45133 BP_3 8.62 0.45 1215 642919843 XP_008192092.1 926 3.3e-97 PREDICTED: TIP41-like protein [Tribolium castaneum]>gi|270005393|gb|EFA01841.1| hypothetical protein TcasGA2_TC007443 [Tribolium castaneum] -- -- -- -- -- K17607 TIPRL, TIP41 type 2A phosphatase activator TIP41 http://www.genome.jp/dbget-bin/www_bget?ko:K17607 O75663 528 1.9e-52 TIP41-like protein OS=Homo sapiens GN=TIPRL PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3224 Uncharacterized conserved protein Cluster-8309.45134 BP_3 82.55 0.80 5293 642912949 XP_008201320.1 755 9.8e-77 PREDICTED: uncharacterized protein LOC103315151 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18407 TDRD5 tudor domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18407 Q4R3G4 152 3.4e-08 RING finger protein 17 OS=Macaca fascicularis GN=RNF17 PE=2 SV=2 PF15151 Response gene to complement 32 protein family GO:0051726 regulation of cell cycle -- -- -- -- -- -- Cluster-8309.45135 BP_3 19.95 1.54 917 478263480 ENN81835.1 246 1.8e-18 hypothetical protein YQE_01774, partial [Dendroctonus ponderosae] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q7TSX5 140 1.4e-07 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Rattus norvegicus GN=Sgms1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45137 BP_3 117.26 1.50 4063 642913773 XP_008201155.1 4296 0.0e+00 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6H8H2 2020 6.4e-225 DENN domain-containing protein 4C OS=Mus musculus GN=Dennd4c PE=1 SV=1 PF04554 Extensin-like region GO:0042546//GO:0009664 cell wall biogenesis//plant-type cell wall organization GO:0005199 structural constituent of cell wall GO:0005618 cell wall KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.45138 BP_3 47.50 0.44 5516 642913773 XP_008201155.1 5958 0.0e+00 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6H8H2 2020 8.6e-225 DENN domain-containing protein 4C OS=Mus musculus GN=Dennd4c PE=1 SV=1 PF01844//PF02861//PF02055 HNH endonuclease//Clp amino terminal domain, pathogenicity island component//O-Glycosyl hydrolase family 30 GO:0006665//GO:0006807//GO:0005975//GO:0019538//GO:0006687 sphingolipid metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process//protein metabolic process//glycosphingolipid metabolic process GO:0004519//GO:0003676//GO:0004348 endonuclease activity//nucleic acid binding//glucosylceramidase activity -- -- KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.45140 BP_3 589.80 2.26 12887 642927168 XP_008195164.1 970 2.8e-101 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47180 731 5.9e-75 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF16093//PF00295 Proteasome assembly chaperone 4//Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0043248//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//proteasome assembly//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.45142 BP_3 141.23 0.54 12935 642927168 XP_008195164.1 970 2.8e-101 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47180 731 6.0e-75 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF16093//PF00295 Proteasome assembly chaperone 4//Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0043248//GO:0005975 sucrose metabolic process//starch metabolic process//proteasome assembly//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.45143 BP_3 37.40 0.31 6027 189234308 XP_971839.2 1959 2.7e-216 PREDICTED: solute carrier family 35 member F3 [Tribolium castaneum] -- -- -- -- -- K15288 SLC35F3_4 solute carrier family 35, member F3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15288 Q1LZI2 549 3.5e-54 Putative thiamine transporter SLC35F3 OS=Mus musculus GN=Slc35f3 PE=2 SV=1 PF00892//PF06027 EamA-like transporter family//Solute carrier family 35 GO:0006810 transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4314 Predicted carbohydrate/phosphate translocator Cluster-8309.45144 BP_3 226.92 159.31 356 429327037 AFZ78847.1 367 6.4e-33 putative cysteine-rich protein 1 [Coptotermes formosanus] -- -- -- -- -- -- -- -- -- P63255 292 1.3e-25 Cysteine-rich protein 1 OS=Rattus norvegicus GN=Crip1 PE=1 SV=2 PF03884//PF00412 Domain of unknown function (DUF329)//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.45145 BP_3 107.35 3.19 1916 642917782 XP_008191284.1 687 2.7e-69 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [Tribolium castaneum] -- -- -- -- -- K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 638 5.4e-65 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF08332 Calcium/calmodulin dependent protein kinase II association domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005516//GO:0004683 calmodulin binding//calmodulin-dependent protein kinase activity -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.45146 BP_3 205.89 2.69 3981 189236323 XP_975243.2 2357 1.3e-262 PREDICTED: condensin complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YHY6 1231 1.9e-133 Condensin complex subunit 1 OS=Xenopus laevis GN=ncapd2 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0414 Chromosome condensation complex Condensin, subunit D2 Cluster-8309.45147 BP_3 467.27 17.19 1602 642929822 XP_975593.2 1060 1.3e-112 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.59798e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.3e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.45148 BP_3 26.91 0.57 2568 642929822 XP_975593.2 1013 5.7e-107 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 1.06654e-46 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 2.1e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.45150 BP_3 13.68 0.48 1657 642929822 XP_975593.2 1036 8.0e-110 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.82956e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.4e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.45151 BP_3 28.05 0.38 3811 91093755 XP_969513.1 1374 1.2e-148 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270012977|gb|EFA09425.1| hypothetical protein TcasGA2_TC010636 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 O15254 928 2.5e-98 Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens GN=ACOX3 PE=1 SV=2 PF05139//PF07716//PF00441//PF07544//PF02770//PF00107//PF01756 Erythromycin esterase//Basic region leucine zipper//Acyl-CoA dehydrogenase, C-terminal domain//RNA polymerase II transcription mediator complex subunit 9//Acyl-CoA dehydrogenase, middle domain//Zinc-binding dehydrogenase//Acyl-CoA oxidase GO:0006118//GO:0006355//GO:0006357//GO:0055114//GO:0006637//GO:0046677//GO:0006631//GO:0006635 obsolete electron transport//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//oxidation-reduction process//acyl-CoA metabolic process//response to antibiotic//fatty acid metabolic process//fatty acid beta-oxidation GO:0043565//GO:0016627//GO:0003700//GO:0003995//GO:0003997//GO:0001104 sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//transcription factor activity, sequence-specific DNA binding//acyl-CoA dehydrogenase activity//acyl-CoA oxidase activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005667//GO:0005777 mediator complex//transcription factor complex//peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.45152 BP_3 154.31 2.40 3394 642916496 XP_008191066.1 2813 0.0e+00 PREDICTED: elongation factor Tu GTP-binding domain-containing protein 1 [Tribolium castaneum]>gi|270003614|gb|EFA00062.1| hypothetical protein TcasGA2_TC002875 [Tribolium castaneum] -- -- -- -- -- K14536 RIA1 ribosome assembly protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14536 Q7Z2Z2 1323 3.5e-144 Elongation factor Tu GTP-binding domain-containing protein 1 OS=Homo sapiens GN=EFTUD1 PE=1 SV=2 PF03764//PF03144//PF02961//PF08477 Elongation factor G, domain IV//Elongation factor Tu domain 2//Barrier to autointegration factor//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0003677//GO:0000166//GO:0005525 DNA binding//nucleotide binding//GTP binding -- -- KOG0467 Translation elongation factor 2/ribosome biogenesis protein RIA1 and related proteins Cluster-8309.45153 BP_3 93.10 3.40 1611 727098966 AIY54302.1 1001 8.8e-106 TATA-box-binding protein 1 [Colaphellus bowringi] -- -- -- -- -- K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 Q9YGV8 507 7.0e-50 TATA box-binding protein-like protein 1 OS=Gallus gallus GN=TBPL1 PE=2 SV=1 PF00352 Transcription factor TFIID (or TATA-binding protein, TBP) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding -- -- KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.45155 BP_3 128.46 0.97 6687 727098966 AIY54302.1 721 1.1e-72 TATA-box-binding protein 1 [Colaphellus bowringi] 762143181 XM_011456532.1 50 4.88555e-14 PREDICTED: Crassostrea gigas TATA box-binding protein-like protein 1 (LOC105347432), mRNA K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 Q9YGV8 339 8.8e-30 TATA box-binding protein-like protein 1 OS=Gallus gallus GN=TBPL1 PE=2 SV=1 PF00352 Transcription factor TFIID (or TATA-binding protein, TBP) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding -- -- KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.45156 BP_3 170.44 1.23 6976 727098966 AIY54302.1 721 1.1e-72 TATA-box-binding protein 1 [Colaphellus bowringi] 762143181 XM_011456532.1 50 5.09786e-14 PREDICTED: Crassostrea gigas TATA box-binding protein-like protein 1 (LOC105347432), mRNA K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 Q9YGV8 339 9.1e-30 TATA box-binding protein-like protein 1 OS=Gallus gallus GN=TBPL1 PE=2 SV=1 PF00352 Transcription factor TFIID (or TATA-binding protein, TBP) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding -- -- KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.45157 BP_3 1041.76 13.39 4042 871211803 XP_012946119.1 440 2.5e-40 PREDICTED: collagen alpha-1(I) chain-like [Aplysia californica] 170039347 XM_001847447.1 45 1.77184e-11 Culex quinquefasciatus collagen alpha 1(XVIII) chain, mRNA K08135 COL15A collagen, type XV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08135 P02453 358 3.3e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF10660//PF06482 Iron-containing outer mitochondrial membrane protein N-terminus//Collagenase NC10 and Endostatin GO:0007155 cell adhesion GO:0005198//GO:0051537 structural molecule activity//2 iron, 2 sulfur cluster binding GO:0043231//GO:0031012 intracellular membrane-bounded organelle//extracellular matrix -- -- Cluster-8309.45159 BP_3 273.97 5.34 2763 270000727 EEZ97174.1 449 1.5e-41 hypothetical protein TcasGA2_TC004361 [Tribolium castaneum] 752865554 XM_011270924.1 89 4.18728e-36 PREDICTED: Camponotus floridanus RNA-binding protein 1-like (LOC105259161), transcript variant X11, mRNA K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q02427 409 2.8e-38 RNA-binding protein 1 OS=Drosophila melanogaster GN=Rbp1 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily) Cluster-8309.45161 BP_3 135.74 7.89 1121 642911480 XP_008199442.1 1056 2.6e-112 PREDICTED: retinol dehydrogenase 13-like [Tribolium castaneum]>gi|270014891|gb|EFA11339.1| hypothetical protein TcasGA2_TC010879 [Tribolium castaneum] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 680 4.2e-70 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0000166 oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.45164 BP_3 504.94 2.45 10235 642935247 XP_008197929.1 5389 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 780 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1750 3.3e-193 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF00041//PF13895//PF13443//PF16656//PF05506 Fibronectin type III domain//Immunoglobulin domain//Cro/C1-type HTH DNA-binding domain//Purple acid Phosphatase, N-terminal domain//Domain of unknown function (DUF756) GO:0019497//GO:0009395//GO:0006771//GO:0016042 hexachlorocyclohexane metabolic process//phospholipid catabolic process//riboflavin metabolic process//lipid catabolic process GO:0005515//GO:0046872//GO:0004629//GO:0003993//GO:0043565 protein binding//metal ion binding//phospholipase C activity//acid phosphatase activity//sequence-specific DNA binding -- -- -- -- Cluster-8309.45165 BP_3 202.08 0.91 10986 642935247 XP_008197929.1 4423 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 727 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1750 3.5e-193 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF00041//PF16656//PF13443//PF05506 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Cro/C1-type HTH DNA-binding domain//Domain of unknown function (DUF756) GO:0019497//GO:0009395//GO:0006771//GO:0016042 hexachlorocyclohexane metabolic process//phospholipid catabolic process//riboflavin metabolic process//lipid catabolic process GO:0005515//GO:0004629//GO:0046872//GO:0043565//GO:0003993 protein binding//phospholipase C activity//metal ion binding//sequence-specific DNA binding//acid phosphatase activity -- -- -- -- Cluster-8309.45167 BP_3 6.65 18.61 283 270001017 EEZ97464.1 364 1.1e-32 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 331 3.1e-30 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF02137 Adenosine-deaminase (editase) domain GO:0006807//GO:0006144//GO:0006396 nitrogen compound metabolic process//purine nucleobase metabolic process//RNA processing GO:0004000//GO:0003723 adenosine deaminase activity//RNA binding -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.45168 BP_3 13.10 0.31 2322 478256208 ENN76402.1 688 2.5e-69 hypothetical protein YQE_07063, partial [Dendroctonus ponderosae] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q5H8C4 285 5.6e-24 Vacuolar protein sorting-associated protein 13A OS=Mus musculus GN=Vps13a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.45169 BP_3 21.96 0.59 2079 478258252 ENN78381.1 1023 3.2e-108 hypothetical protein YQE_05182, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 212 1.5e-15 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00018//PF14604//PF00621 SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.45170 BP_3 169.10 0.65 12816 270013710 EFA10158.1 5454 0.0e+00 hypothetical protein TcasGA2_TC012347 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 5.2e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF03400//PF06553//PF13606//PF00023//PF00960//PF05510//PF00536 IS1 transposase//BNIP3//Ankyrin repeat//Ankyrin repeat//Neocarzinostatin family//Sarcoglycan alpha/epsilon//SAM domain (Sterile alpha motif) GO:0043065//GO:0006313//GO:0006952 positive regulation of apoptotic process//transposition, DNA-mediated//defense response GO:0004803//GO:0003677//GO:0005515 transposase activity//DNA binding//protein binding GO:0005740//GO:0016012//GO:0016021 mitochondrial envelope//sarcoglycan complex//integral component of membrane -- -- Cluster-8309.45172 BP_3 87.00 3.18 1610 -- -- -- -- -- 642911032 XM_008195295.1 170 2.26993e-81 PREDICTED: Tribolium castaneum small conductance calcium-activated potassium channel protein (LOC657962), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45173 BP_3 90.69 0.98 4748 270009357 EFA05805.1 2702 1.5e-302 hypothetical protein TcasGA2_TC030720 [Tribolium castaneum] -- -- -- -- -- K10875 RAD54L, RAD54 DNA repair and recombination protein RAD54 and RAD54-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K10875 O12944 1957 1.5e-217 DNA repair and recombination protein RAD54-like (Fragment) OS=Gallus gallus GN=RAD54L PE=2 SV=1 PF00176//PF01484//PF04851//PF08658 SNF2 family N-terminal domain//Nematode cuticle collagen N-terminal domain//Type III restriction enzyme, res subunit//Rad54 N terminal -- -- GO:0042302//GO:0016817//GO:0016787//GO:0003677//GO:0005524 structural constituent of cuticle//hydrolase activity, acting on acid anhydrides//hydrolase activity//DNA binding//ATP binding -- -- KOG0390 DNA repair protein, SNF2 family Cluster-8309.45174 BP_3 54.50 0.35 7812 91091506 XP_969096.1 3532 0.0e+00 PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|642936851|ref|XP_008197901.1| PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|270000934|gb|EEZ97381.1| hypothetical protein TcasGA2_TC011206 [Tribolium castaneum] 170030268 XM_001842960.1 189 3.06985e-91 Culex quinquefasciatus ubiquitin-protein ligase E3A, mRNA K10587 UBE3A, E6AP ubiquitin-protein ligase E3 A http://www.genome.jp/dbget-bin/www_bget?ko:K10587 Q05086 2156 2.1e-240 Ubiquitin-protein ligase E3A OS=Homo sapiens GN=UBE3A PE=1 SV=4 PF15798//PF00895//PF00632 Proline-rich AKT1 substrate 1//ATP synthase protein 8//HECT-domain (ubiquitin-transferase) GO:0048011//GO:0016567//GO:0032007//GO:0015986//GO:0015992 neurotrophin TRK receptor signaling pathway//protein ubiquitination//negative regulation of TOR signaling//ATP synthesis coupled proton transport//proton transport GO:0004842//GO:0015078 ubiquitin-protein transferase activity//hydrogen ion transmembrane transporter activity GO:0000276//GO:0005622 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//intracellular KOG0941 E3 ubiquitin protein ligase Cluster-8309.45176 BP_3 1632.95 13.41 6161 189240296 XP_973610.2 2451 2.5e-273 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 P55156 752 1.0e-77 Microsomal triglyceride transfer protein large subunit (Fragment) OS=Bos taurus GN=MTTP PE=1 SV=1 PF09172//PF00019//PF01347 Domain of unknown function (DUF1943)//Transforming growth factor beta like domain//Lipoprotein amino terminal region GO:0006869//GO:0008283//GO:0040007//GO:0007165 lipid transport//cell proliferation//growth//signal transduction GO:0005319//GO:0008083 lipid transporter activity//growth factor activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.45178 BP_3 735.42 9.89 3876 512892422 XP_004922927.1 1138 2.8e-121 PREDICTED: uncharacterized protein LOC101739908 [Bombyx mori] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 468 5.6e-45 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.45180 BP_3 123.97 1.05 5969 642926198 XP_008194826.1 5231 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein castor homolog 1-like [Tribolium castaneum] 645021609 XM_008209379.1 386 0 PREDICTED: Nasonia vitripennis zinc finger protein castor homolog 1-like (LOC100116283), partial mRNA -- -- -- -- Q7M3M8 877 3.2e-92 Transcription factor castor OS=Drosophila melanogaster GN=cas PE=1 SV=2 PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.45184 BP_3 138.31 1.81 3966 642922116 XP_008193022.1 736 1.2e-74 PREDICTED: calcium channel flower isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MXW6 352 1.6e-31 Calcium channel flower OS=Drosophila willistoni GN=flower PE=3 SV=2 PF03613//PF10233 PTS system mannose/fructose/sorbose family IID component//Uncharacterized conserved protein CG6151-P GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021 integral component of membrane KOG4085 Uncharacterized conserved protein Cluster-8309.45185 BP_3 1738.28 27.92 3293 478258600 ENN78650.1 1780 8.5e-196 hypothetical protein YQE_04823, partial [Dendroctonus ponderosae]>gi|546676605|gb|ERL87577.1| hypothetical protein D910_04968 [Dendroctonus ponderosae] 696999013 XM_009567460.1 74 1.09023e-27 PREDICTED: Cuculus canorus regulatory solute carrier protein, family 1, member 1 (RSC1A1), mRNA K11885 DDI1 DNA damage-inducible protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11885 Q497D6 986 4.1e-105 Protein DDI1 homolog 2 OS=Xenopus tropicalis GN=ddi2 PE=2 SV=1 PF09668//PF00240 Aspartyl protease//Ubiquitin family GO:0006508 proteolysis GO:0004190//GO:0005515 aspartic-type endopeptidase activity//protein binding -- -- KOG0012 DNA damage inducible protein Cluster-8309.45188 BP_3 33.94 0.92 2068 642927514 XP_008195300.1 944 4.6e-99 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] -- -- -- -- -- K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 414 5.4e-39 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1365 RNA-binding protein Fusilli, contains RRM domain Cluster-8309.45189 BP_3 800.18 26.54 1745 91091630 XP_970163.1 1498 2.2e-163 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial [Tribolium castaneum]>gi|270000896|gb|EEZ97343.1| hypothetical protein TcasGA2_TC011159 [Tribolium castaneum] 572261461 XM_006608952.1 211 3.98064e-104 PREDICTED: Apis dorsata pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like (LOC102674287), transcript variant X3, mRNA K00162 PDHB, pdhB pyruvate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00162 O44451 1220 1.6e-132 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Caenorhabditis elegans GN=pdhb-1 PE=1 SV=2 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.4519 BP_3 5.00 0.33 1019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45190 BP_3 162.25 3.24 2708 642927435 XP_008195272.1 827 2.2e-85 PREDICTED: UPF0183 protein CG7083 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSH9 574 2.0e-57 UPF0183 protein CG7083 OS=Drosophila melanogaster GN=CG7083 PE=2 SV=1 PF05094 Late expression factor 9 (LEF-9) GO:0019083 viral transcription -- -- -- -- KOG2819 Uncharacterized conserved protein Cluster-8309.45191 BP_3 389.58 5.78 3538 91085889 XP_967833.1 1816 6.1e-200 PREDICTED: UPF0183 protein CG7083 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSH9 1366 3.8e-149 UPF0183 protein CG7083 OS=Drosophila melanogaster GN=CG7083 PE=2 SV=1 PF05094 Late expression factor 9 (LEF-9) GO:0019083 viral transcription -- -- -- -- KOG2819 Uncharacterized conserved protein Cluster-8309.45192 BP_3 20.57 0.48 2372 642916614 XP_008191899.1 1314 6.6e-142 PREDICTED: LOW QUALITY PROTEIN: suppressor of cytokine signaling 5 [Tribolium castaneum] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 2.9e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.45193 BP_3 253.38 2.36 5471 270011060 EFA07508.1 2488 1.1e-277 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28666 738 3.9e-76 Murinoglobulin-2 OS=Mus musculus GN=Mug2 PE=2 SV=2 PF07678//PF07677//PF01835//PF00207//PF01483 A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain//Alpha-2-macroglobulin family//Proprotein convertase P-domain GO:0006508 proteolysis GO:0004252//GO:0004866 serine-type endopeptidase activity//endopeptidase inhibitor activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.45194 BP_3 468.50 2.17 10705 642914280 XP_008201619.1 1367 2.1e-147 PREDICTED: cyclic AMP-dependent transcription factor ATF-6 beta [Tribolium castaneum] 332375533 BT127946.1 81 4.58532e-31 Dendroctonus ponderosae clone DPO1025_H21 unknown mRNA K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q6GM78 703 8.7e-72 Isoaspartyl peptidase/L-asparaginase OS=Xenopus laevis GN=asrgl1 PE=2 SV=1 PF00170//PF00096//PF06005//PF06156//PF03604//PF12356//PF07716//PF07975//PF01166//PF03131//PF13912//PF01363//PF16866//PF04275//PF04977//PF14861//PF06467//PF07776//PF13465//PF03453//PF01112 bZIP transcription factor//Zinc finger, C2H2 type//Protein of unknown function (DUF904)//Protein of unknown function (DUF972)//DNA directed RNA polymerase, 7 kDa subunit//Protein of unknown function (DUF3643)//Basic region leucine zipper//TFIIH C1-like domain//TSC-22/dip/bun family//bZIP Maf transcription factor//C2H2-type zinc finger//FYVE zinc finger//PHD-finger//Phosphomevalonate kinase//Septum formation initiator//Plant antimicrobial peptide//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//MoeA N-terminal region (domain I and II)//Asparaginase GO:0016567//GO:0006144//GO:0032324//GO:0006351//GO:0043093//GO:0000917//GO:0006695//GO:0006206//GO:0032465//GO:0006281//GO:0050832//GO:0006915//GO:0006694//GO:0007049//GO:0006260//GO:0006355 protein ubiquitination//purine nucleobase metabolic process//molybdopterin cofactor biosynthetic process//transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly//cholesterol biosynthetic process//pyrimidine nucleobase metabolic process//regulation of cytokinesis//DNA repair//defense response to fungus//apoptotic process//steroid biosynthetic process//cell cycle//DNA replication//regulation of transcription, DNA-templated GO:0005515//GO:0004842//GO:0003677//GO:0046872//GO:0016787//GO:0003899//GO:0004631//GO:0003700//GO:0008270//GO:0043565 protein binding//ubiquitin-protein transferase activity//DNA binding//metal ion binding//hydrolase activity//DNA-directed RNA polymerase activity//phosphomevalonate kinase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005730//GO:0005737 transcription factor complex//nucleus//nucleolus//cytoplasm KOG1592 Asparaginase Cluster-8309.45196 BP_3 18.90 0.73 1540 91077766 XP_968426.1 1279 4.9e-138 PREDICTED: WD repeat domain phosphoinositide-interacting protein 4 [Tribolium castaneum]>gi|270002238|gb|EEZ98685.1| hypothetical protein TcasGA2_TC001220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCV0 1046 2.1e-112 WD repeat domain phosphoinositide-interacting protein 4 OS=Xenopus laevis GN=wdr45 PE=2 SV=1 PF00400//PF03178 WD domain, G-beta repeat//CPSF A subunit region -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.45198 BP_3 6.00 0.36 1097 62897709 BAD96794.1 584 1.4e-57 lymphocyte antigen 6 complex, locus E variant [Homo sapiens] 187827163 NM_002346.2 1094 0 Homo sapiens lymphocyte antigen 6 complex, locus E (LY6E), transcript variant 1, mRNA K06846 LY6 lymphocyte antigen 6 complex http://www.genome.jp/dbget-bin/www_bget?ko:K06846 Q16553 588 1.9e-59 Lymphocyte antigen 6E OS=Homo sapiens GN=LY6E PE=2 SV=1 PF00087 Snake toxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.45199 BP_3 192.81 3.39 3031 91080705 XP_975304.1 881 1.4e-91 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270005473|gb|EFA01921.1| hypothetical protein TcasGA2_TC007531 [Tribolium castaneum] -- -- -- -- -- K17352 TSPAN11 tetraspanin-11 http://www.genome.jp/dbget-bin/www_bget?ko:K17352 Q9QZA6 364 5.0e-33 CD151 antigen OS=Rattus norvegicus GN=Cd151 PE=1 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.452 BP_3 18.06 0.43 2295 189239672 XP_001813945.1 1283 2.5e-138 PREDICTED: serine proteinase stubble [Tribolium castaneum]>gi|270011208|gb|EFA07656.1| hypothetical protein TcasGA2_TC030609 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 650 2.6e-66 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00548//PF00089 3C cysteine protease (picornain 3C)//Trypsin GO:0006508 proteolysis GO:0004252//GO:0004197 serine-type endopeptidase activity//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.4520 BP_3 90.91 6.05 1016 478254654 ENN74895.1 839 3.4e-87 hypothetical protein YQE_08473, partial [Dendroctonus ponderosae] 817052986 XM_012404120.1 175 2.35231e-84 PREDICTED: Athalia rosae SUMO-conjugating enzyme UBC9-B (LOC105688078), mRNA K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 Q9DDJ0 751 2.2e-78 SUMO-conjugating enzyme UBC9-B OS=Danio rerio GN=ube2ib PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.45200 BP_3 126.83 1.50 4367 546686080 ERL95480.1 617 8.1e-61 hypothetical protein D910_12742 [Dendroctonus ponderosae] -- -- -- -- -- K03434 PIGL N-acetylglucosaminylphosphatidylinositol deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K03434 Q9Y2B2 355 8.0e-32 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase OS=Homo sapiens GN=PIGL PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3332 N-acetylglucosaminyl phosphatidylinositol de-N-acetylase Cluster-8309.45201 BP_3 32.00 0.99 1855 91077582 XP_973057.1 519 7.9e-50 PREDICTED: uncharacterized protein LOC661830 isoform X1 [Tribolium castaneum]>gi|270001568|gb|EEZ98015.1| hypothetical protein TcasGA2_TC000415 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45202 BP_3 107.59 2.70 2214 642914209 XP_008201591.1 790 3.6e-81 PREDICTED: uncharacterized protein LOC661830 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.45203 BP_3 295.52 4.27 3630 549438545 AGX25161.1 2415 2.2e-269 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 1472 2.0e-161 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF00326//PF01738//PF03583//PF12537//PF00930//PF02129 Prolyl oligopeptidase family//Dienelactone hydrolase family//Secretory lipase//The Golgi pH Regulator (GPHR) Family N-terminal//Dipeptidyl peptidase IV (DPP IV) N-terminal region//X-Pro dipeptidyl-peptidase (S15 family) GO:0046486//GO:0016042//GO:0006508 glycerolipid metabolic process//lipid catabolic process//proteolysis GO:0004806//GO:0008236//GO:0016787 triglyceride lipase activity//serine-type peptidase activity//hydrolase activity GO:0016020 membrane KOG2100 Dipeptidyl aminopeptidase Cluster-8309.45204 BP_3 228.59 2.03 5719 642928819 XP_008195574.1 1389 3.2e-150 PREDICTED: transcriptional repressor p66-alpha isoform X1 [Tribolium castaneum] 642928820 XM_008197353.1 64 6.89046e-22 PREDICTED: Tribolium castaneum transcriptional repressor p66-alpha (LOC656529), transcript variant X2, mRNA -- -- -- -- Q8WXI9 344 2.0e-30 Transcriptional repressor p66-beta OS=Homo sapiens GN=GATAD2B PE=1 SV=1 PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667 transcription factor complex -- -- Cluster-8309.45205 BP_3 181.36 6.46 1645 91081763 XP_973188.1 796 5.3e-82 PREDICTED: UDP-glucuronosyltransferase 2B20 [Tribolium castaneum]>gi|270005052|gb|EFA01500.1| hypothetical protein TcasGA2_TC007056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 374 1.9e-34 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.45207 BP_3 235.49 1.31 8971 642917303 XP_008199243.1 6908 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X4 [Tribolium castaneum] 665815961 XM_008558446.1 643 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3679 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF06464//PF02710//PF02784//PF00501//PF01297 DMAP1-binding Domain//Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein//Pyridoxal-dependent decarboxylase, pyridoxal binding domain//AMP-binding enzyme//Zinc-uptake complex component A periplasmic GO:0030001//GO:0007165//GO:0008152//GO:0019064 metal ion transport//signal transduction//metabolic process//fusion of virus membrane with host plasma membrane GO:0016788//GO:0003824//GO:0008134//GO:0046789//GO:0046872 hydrolase activity, acting on ester bonds//catalytic activity//transcription factor binding//host cell surface receptor binding//metal ion binding GO:0005634//GO:0005667//GO:0019031//GO:0009986 nucleus//transcription factor complex//viral envelope//cell surface KOG3628 Predicted AMP-binding protein Cluster-8309.45208 BP_3 165.64 1.49 5652 478257589 ENN77743.1 1238 1.0e-132 hypothetical protein YQE_05813, partial [Dendroctonus ponderosae]>gi|546677142|gb|ERL88039.1| hypothetical protein D910_05428 [Dendroctonus ponderosae] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 792 2.2e-82 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF02254//PF15453//PF03435//PF02325//PF01408//PF13241//PF00389//PF00899//PF02826//PF03446 TrkA-N domain//Protein incorporated later into Tight Junctions//Saccharopine dehydrogenase NADP binding domain//YGGT family//Oxidoreductase family, NAD-binding Rossmann fold//Putative NAD(P)-binding//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006813//GO:0008152//GO:0019354//GO:0006098//GO:0055114//GO:0006779//GO:0019521 potassium ion transport//metabolic process//siroheme biosynthetic process//pentose-phosphate shunt//oxidation-reduction process//porphyrin-containing compound biosynthetic process//D-gluconate metabolic process GO:0051287//GO:0016616//GO:0016491//GO:0043115//GO:0008641//GO:0004616 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//precorrin-2 dehydrogenase activity//small protein activating enzyme activity//phosphogluconate dehydrogenase (decarboxylating) activity GO:0005923//GO:0016020 bicellular tight junction//membrane -- -- Cluster-8309.45211 BP_3 53.90 0.68 4133 642912871 XP_008201290.1 3785 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X7 [Tribolium castaneum] 642912870 XM_008203068.1 1166 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X7, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1287 6.4e-140 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00130//PF00788//PF00781//PF00076//PF07649//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C1-like domain//PHD-finger GO:0007165//GO:0035556//GO:0055114 signal transduction//intracellular signal transduction//oxidation-reduction process GO:0016301//GO:0003676//GO:0047134//GO:0005515 kinase activity//nucleic acid binding//protein-disulfide reductase activity//protein binding -- -- KOG1169 Diacylglycerol kinase Cluster-8309.45212 BP_3 323.93 2.65 6180 642912869 XP_008201289.1 3556 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X6 [Tribolium castaneum] 642912868 XM_008203067.1 1382 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X6, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1296 8.7e-141 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF07649//PF00628//PF00781//PF00076//PF00609//PF00130//PF00788 C1-like domain//PHD-finger//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain GO:0046486//GO:0035556//GO:0055114//GO:0007205//GO:0009395//GO:0007165 glycerolipid metabolic process//intracellular signal transduction//oxidation-reduction process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//signal transduction GO:0047134//GO:0003676//GO:0016301//GO:0005515//GO:0004143 protein-disulfide reductase activity//nucleic acid binding//kinase activity//protein binding//diacylglycerol kinase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.45215 BP_3 241.30 11.16 1334 270008843 EFA05291.1 961 3.2e-101 hypothetical protein TcasGA2_TC015448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 260 2.5e-21 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4522 BP_3 3.00 0.36 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45221 BP_3 18.64 0.32 3132 332376577 AEE63428.1 1040 5.2e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 550 1.4e-54 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722//PF11522 Peptidase C26//Yeast phosphatidylinositol-4-OH kinase Pik1 GO:0006541 glutamine metabolic process GO:0016787//GO:0016773 hydrolase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.45222 BP_3 6.00 0.35 1122 332376577 AEE63428.1 277 5.5e-22 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q9Z0L8 149 1.6e-08 Gamma-glutamyl hydrolase OS=Mus musculus GN=Ggh PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.45224 BP_3 1.00 2.28 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45225 BP_3 36.00 4.90 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45226 BP_3 10.11 0.34 1716 270297202 NP_001161902.1 988 3.0e-104 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q25489 845 4.8e-89 Juvenile hormone epoxide hydrolase OS=Manduca sexta PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.45227 BP_3 1.00 1.52 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45231 BP_3 94.60 1.07 4566 642934390 XP_008197640.1 2185 1.3e-242 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Tribolium castaneum] 462277993 APGK01058794.1 35 7.25738e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 813 6.5e-85 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.45233 BP_3 99.55 1.35 3838 642921365 XP_972788.2 3525 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 1.99825e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1310 1.3e-142 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF12861//PF12678//PF00097//PF00787//PF13639 Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//PX domain//Ring finger domain GO:0016567 protein ubiquitination GO:0005515//GO:0035091//GO:0046872//GO:0004842//GO:0008270 protein binding//phosphatidylinositol binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.45234 BP_3 43.21 0.31 6938 91083881 XP_967558.1 1012 2.0e-106 PREDICTED: D-3-phosphoglycerate dehydrogenase [Tribolium castaneum]>gi|270006715|gb|EFA03163.1| hypothetical protein TcasGA2_TC013082 [Tribolium castaneum] -- -- -- -- -- K00058 serA, PHGDH D-3-phosphoglycerate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00058 O08651 676 7.6e-69 D-3-phosphoglycerate dehydrogenase OS=Rattus norvegicus GN=Phgdh PE=1 SV=3 PF00389//PF02826//PF07347 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) GO:0006814//GO:0006744//GO:0006566//GO:0006544//GO:0055114//GO:0006564//GO:0015992//GO:0008152//GO:0042773//GO:0006120 sodium ion transport//ubiquinone biosynthetic process//threonine metabolic process//glycine metabolic process//oxidation-reduction process//L-serine biosynthetic process//proton transport//metabolic process//ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone GO:0004617//GO:0008137//GO:0051287//GO:0016616 phosphoglycerate dehydrogenase activity//NADH dehydrogenase (ubiquinone) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005743 mitochondrial inner membrane KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily Cluster-8309.45235 BP_3 13.00 35.42 284 307196158 EFN77820.1 287 9.6e-24 hypothetical protein EAI_03910, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45237 BP_3 250.27 3.70 3551 861603962 KMQ84139.1 355 1.6e-30 histone-lysine n-methyltransferase setmar [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45239 BP_3 39.70 0.96 2277 861603962 KMQ84139.1 349 5.0e-30 histone-lysine n-methyltransferase setmar [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45240 BP_3 1371.56 15.94 4439 642912959 XP_008201326.1 2864 0.0e+00 PREDICTED: programmed cell death 6-interacting protein [Tribolium castaneum]>gi|270001905|gb|EEZ98352.1| hypothetical protein TcasGA2_TC000807 [Tribolium castaneum] -- -- -- -- -- K12200 PDCD6IP, ALIX, RIM20 programmed cell death 6-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12200 Q9W6C5 1514 3.3e-166 Programmed cell death 6-interacting protein OS=Xenopus laevis GN=pdcd6ip PE=1 SV=1 PF04111//PF17082//PF13949 Autophagy protein Apg6//Spindle Pole Component 29//ALIX V-shaped domain binding to HIV GO:0030474//GO:0006914 spindle pole body duplication//autophagy GO:0005200//GO:0005515 structural constituent of cytoskeleton//protein binding GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG2220 Predicted signal transduction protein Cluster-8309.45242 BP_3 140.64 3.16 2437 91076754 XP_973519.1 1295 1.1e-139 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P30638 168 2.2e-10 Putative transporter ZK637.1 OS=Caenorhabditis elegans GN=ZK637.1 PE=3 SV=5 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.45245 BP_3 55.00 0.70 4098 861619777 KMQ87102.1 2897 0.0e+00 blastopia polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 776 1.1e-80 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00098//PF09668 Zinc knuckle//Aspartyl protease GO:0006508 proteolysis GO:0008270//GO:0003676//GO:0004190 zinc ion binding//nucleic acid binding//aspartic-type endopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.45249 BP_3 108.30 1.71 3341 91076754 XP_973519.1 817 4.0e-84 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63564 313 4.5e-27 Synaptic vesicle glycoprotein 2B OS=Rattus norvegicus GN=Sv2b PE=1 SV=1 PF05631//PF07690//PF00083 Sugar-tranasporters, 12 TM//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0015689 transmembrane transport//molybdate ion transport GO:0022857//GO:0015098 transmembrane transporter activity//molybdate ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.4525 BP_3 68.01 4.74 983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45250 BP_3 322.67 4.96 3428 345489096 XP_001604048.2 2041 4.8e-226 PREDICTED: organic cation transporter protein-like [Nasonia vitripennis] 815793565 XM_012361984.1 64 4.1127e-22 PREDICTED: Linepithema humile uncharacterized LOC105669183 (LOC105669183), mRNA -- -- -- -- Q9VCA2 639 7.3e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.45251 BP_3 752.41 21.22 2001 91091236 XP_967765.1 731 2.2e-74 PREDICTED: golgin subfamily A member 7 [Tribolium castaneum]>gi|642936471|ref|XP_008198449.1| PREDICTED: golgin subfamily A member 7 [Tribolium castaneum]>gi|270014108|gb|EFA10556.1| hypothetical protein TcasGA2_TC012812 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D428 419 1.4e-39 Golgin subfamily A member 7B OS=Mus musculus GN=GOLGA7B PE=1 SV=1 PF03650 Uncharacterised protein family (UPF0041) GO:0006850 mitochondrial pyruvate transport -- -- GO:0005743 mitochondrial inner membrane KOG4069 Uncharacterized conserved protein Cluster-8309.45253 BP_3 15.66 0.34 2504 741829858 AJA91073.1 1179 3.2e-126 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 919 1.8e-97 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.45259 BP_3 110.31 1.46 3923 91087131 XP_975238.1 1903 5.5e-210 PREDICTED: trifunctional enzyme subunit beta, mitochondrial [Tribolium castaneum]>gi|270009593|gb|EFA06041.1| hypothetical protein TcasGA2_TC008872 [Tribolium castaneum] -- -- -- -- -- K07509 HADHB acetyl-CoA acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07509 O46629 1462 3.1e-160 Trifunctional enzyme subunit beta, mitochondrial OS=Bos taurus GN=HADHB PE=2 SV=1 PF08541//PF02803//PF08545//PF00108 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//Thiolase, C-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0006633//GO:0008152//GO:0008610 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process//metabolic process//lipid biosynthetic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1068 Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases Cluster-8309.4526 BP_3 4.43 0.34 924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45261 BP_3 783.99 31.20 1503 332376360 AEE63320.1 1078 9.7e-115 unknown [Dendroctonus ponderosae] 821454901 XM_003756308.2 97 8.05256e-41 PREDICTED: Sarcophilus harrisii proteasome (prosome, macropain) subunit, alpha type, 3 (PSMA3), mRNA K02727 PSMA3 20S proteasome subunit alpha 7 http://www.genome.jp/dbget-bin/www_bget?ko:K02727 P25788 866 1.5e-91 Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 SV=2 PF00227//PF01896//PF10584 Proteasome subunit//Eukaryotic and archaeal DNA primase small subunit//Proteasome subunit A N-terminal signature GO:0006351//GO:0006511//GO:0006269//GO:0051603 transcription, DNA-templated//ubiquitin-dependent protein catabolic process//DNA replication, synthesis of RNA primer//proteolysis involved in cellular protein catabolic process GO:0003896//GO:0004175//GO:0004298 DNA primase activity//endopeptidase activity//threonine-type endopeptidase activity GO:0005657//GO:0005839//GO:0019773//GO:0005730 replication fork//proteasome core complex//proteasome core complex, alpha-subunit complex//nucleolus KOG0184 20S proteasome, regulatory subunit alpha type PSMA3/PRE10 Cluster-8309.45263 BP_3 455.16 6.03 3929 646720840 KDR22423.1 602 4.0e-59 hypothetical protein L798_01417, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6P1L5 275 1.4e-22 Protein FAM117B OS=Homo sapiens GN=FAM117B PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45264 BP_3 574.51 18.07 1824 646720840 KDR22423.1 768 1.0e-78 hypothetical protein L798_01417, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q3U3E2 273 1.1e-22 Protein FAM117B OS=Mus musculus GN=Fam117b PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45265 BP_3 0.79 0.63 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45266 BP_3 354.00 156.97 399 642911627 XP_968106.2 244 1.3e-18 PREDICTED: uncharacterized protein LOC656487 [Tribolium castaneum]>gi|270015130|gb|EFA11578.1| hypothetical protein TcasGA2_TC004750 [Tribolium castaneum] -- -- -- -- -- K03945 NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45267 BP_3 2.00 0.88 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45269 BP_3 253.17 7.82 1853 820805548 AKG92765.1 895 2.0e-93 net [Leptinotarsa decemlineata] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q07417 308 9.5e-27 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acads PE=1 SV=2 PF00010//PF00441 Helix-loop-helix DNA-binding domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016627//GO:0046983 oxidoreductase activity, acting on the CH-CH group of donors//protein dimerization activity -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.45271 BP_3 11.12 0.44 1503 642929396 XP_008195819.1 599 3.4e-59 PREDICTED: neogenin isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06583 Neogenin C-terminus -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45274 BP_3 56.88 0.92 3263 642938573 XP_969296.2 2189 3.1e-243 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum]>gi|642938575|ref|XP_008199847.1| PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum] 195573452 XM_002104672.1 41 2.38836e-09 Drosophila simulans GD21091 (Dsim\GD21091), mRNA K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 1709 5.9e-189 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.45275 BP_3 236.51 5.06 2545 546684308 ERL94013.1 1156 1.5e-123 hypothetical protein D910_11297 [Dendroctonus ponderosae] -- -- -- -- -- K15446 TRM13, CCDC76 tRNA:m4X modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15446 Q9NUP7 616 2.5e-62 tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens GN=TRMT13 PE=1 SV=2 PF11722//PF02077//PF05206 CCCH zinc finger in TRM13 protein//SURF4 family//Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity GO:0016021 integral component of membrane KOG2811 Uncharacterized conserved protein Cluster-8309.45277 BP_3 786.98 4.02 9725 642935247 XP_008197929.1 5274 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 774 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1668 1.0e-183 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13443//PF16656//PF00041//PF13895//PF05506 Cro/C1-type HTH DNA-binding domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//Domain of unknown function (DUF756) GO:0016042//GO:0006771//GO:0019497//GO:0009395 lipid catabolic process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//phospholipid catabolic process GO:0046872//GO:0004629//GO:0003993//GO:0043565//GO:0005515 metal ion binding//phospholipase C activity//acid phosphatase activity//sequence-specific DNA binding//protein binding -- -- -- -- Cluster-8309.45278 BP_3 118.96 4.21 1653 642920923 XP_008192617.1 786 7.8e-81 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q6GMC7 430 6.1e-41 Alcohol dehydrogenase [NADP(+)] OS=Xenopus laevis GN=akr1a1 PE=2 SV=1 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.45279 BP_3 1090.16 13.75 4114 546681074 ERL91230.1 1528 1.8e-166 hypothetical protein D910_08566 [Dendroctonus ponderosae] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 883 4.5e-93 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.45280 BP_3 2962.32 25.51 5889 642915588 XP_008190677.1 7722 0.0e+00 PREDICTED: tyrosine-protein phosphatase Lar isoform X3 [Tribolium castaneum] 821135605 XM_012519131.1 232 2.88645e-115 PREDICTED: Dasypus novemcinctus protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant X15, mRNA K05695 PTPRF, LAR receptor-type tyrosine-protein phosphatase F http://www.genome.jp/dbget-bin/www_bget?ko:K05695 P16621 6820 0.0e+00 Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 PF00102//PF16656//PF00041//PF09472//PF01108//PF00782 Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Tissue factor//Dual specificity phosphatase, catalytic domain GO:0006771//GO:0019497//GO:0046656//GO:0006570//GO:0006470//GO:0015948 riboflavin metabolic process//hexachlorocyclohexane metabolic process//folic acid biosynthetic process//tyrosine metabolic process//protein dephosphorylation//methanogenesis GO:0046872//GO:0003993//GO:0004725//GO:0005515//GO:0008138//GO:0030269 metal ion binding//acid phosphatase activity//protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane -- -- Cluster-8309.45283 BP_3 1235.50 7.16 8614 642926407 XP_008191950.1 2727 3.4e-305 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 1.43715e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 3.1e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF10541//PF02376//PF00046//PF11593//PF02121//PF05920//PF03699 Nuclear envelope localisation domain//CUT domain//Homeobox domain//Mediator complex subunit 3 fungal//Phosphatidylinositol transfer protein//Homeobox KN domain//Uncharacterised protein family (UPF0182) GO:0006357//GO:0006355//GO:0006810 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//transport GO:0001104//GO:0003677 RNA polymerase II transcription cofactor activity//DNA binding GO:0005622//GO:0016592//GO:0016021 intracellular//mediator complex//integral component of membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.45284 BP_3 734.21 20.31 2034 546681357 ERL91467.1 785 1.2e-80 hypothetical protein D910_08797 [Dendroctonus ponderosae] -- -- -- -- -- K02265 COX5B cytochrome c oxidase subunit 5b http://www.genome.jp/dbget-bin/www_bget?ko:K02265 Q53HC9 387 7.3e-36 Protein TSSC1 OS=Homo sapiens GN=TSSC1 PE=1 SV=2 PF03121//PF01215 Herpesviridae UL52/UL70 DNA primase//Cytochrome c oxidase subunit Vb GO:0006260//GO:0006269//GO:0015992//GO:0006351//GO:0006123 DNA replication//DNA replication, synthesis of RNA primer//proton transport//transcription, DNA-templated//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003896 cytochrome-c oxidase activity//DNA primase activity GO:0005740//GO:0005730//GO:0005657//GO:0045277 mitochondrial envelope//nucleolus//replication fork//respiratory chain complex IV KOG3352 Cytochrome c oxidase, subunit Vb/COX4 Cluster-8309.45285 BP_3 472.93 5.34 4557 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 4.7e-261 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF07646//PF00651//PF01344 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.45286 BP_3 2843.81 20.29 7046 91085525 XP_972127.1 4732 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 isoform X1 [Tribolium castaneum]>gi|270008364|gb|EFA04812.1| hypothetical protein TcasGA2_TC014862 [Tribolium castaneum] 158287320 XM_309375.4 117 2.92855e-51 Anopheles gambiae str. PEST AGAP011271-PA (AgaP_AGAP011271) mRNA, partial cds K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 2155 2.4e-240 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF04346//PF00122 P5-type ATPase cation transporter//Ethanolamine utilisation protein, EutH//E1-E2 ATPase GO:0034229//GO:0006200//GO:0006812 ethanolamine transport//obsolete ATP catabolic process//cation transport GO:0005524//GO:0015662//GO:0034228//GO:0000166//GO:0016887//GO:0046872 ATP binding//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//ethanolamine transmembrane transporter activity//nucleotide binding//ATPase activity//metal ion binding GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.45287 BP_3 41.84 0.82 2756 546681672 ERL91720.1 1514 5.0e-165 hypothetical protein D910_09047 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01465//PF02041//PF13855 GRIP domain//Auxin binding protein//Leucine rich repeat GO:0000042//GO:0007165 protein targeting to Golgi//signal transduction GO:0004872//GO:0005515 receptor activity//protein binding -- -- -- -- Cluster-8309.45288 BP_3 15.24 0.43 2016 270013489 EFA09937.1 184 6.0e-11 hypothetical protein TcasGA2_TC012090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45289 BP_3 27.73 0.48 3086 332374052 AEE62167.1 738 5.3e-75 unknown [Dendroctonus ponderosae]>gi|478263264|gb|ENN81648.1| hypothetical protein YQE_01946, partial [Dendroctonus ponderosae]>gi|546673295|gb|ERL84927.1| hypothetical protein D910_02350 [Dendroctonus ponderosae] 831570078 XM_012879141.1 114 5.93094e-50 PREDICTED: Fundulus heteroclitus ubiquitin-conjugating enzyme E2E 1 (ube2e1), transcript variant X2, mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P52485 668 2.9e-68 Ubiquitin-conjugating enzyme E2-24 kDa OS=Drosophila melanogaster GN=UbcD2 PE=2 SV=1 PF02060//PF05773 Slow voltage-gated potassium channel//RWD domain GO:0006811//GO:0006813 ion transport//potassium ion transport GO:0005515//GO:0005249 protein binding//voltage-gated potassium channel activity GO:0008076//GO:0016020 voltage-gated potassium channel complex//membrane KOG0417 Ubiquitin-protein ligase Cluster-8309.4529 BP_3 18.32 0.53 1967 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03694 Erg28 like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45293 BP_3 312.91 1.82 8571 642910643 XP_008200041.1 6865 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: plexin-B [Tribolium castaneum] 571537979 XM_395735.5 266 5.29061e-134 PREDICTED: Apis mellifera plexin B (plexB), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 Q9V4A7 4832 0.0e+00 Plexin-B OS=Drosophila melanogaster GN=plexB PE=1 SV=2 PF01833//PF01756//PF02854//PF01403//PF01437 IPT/TIG domain//Acyl-CoA oxidase//MIF4G domain//Sema domain//Plexin repeat GO:0055114//GO:0006637//GO:0006635 oxidation-reduction process//acyl-CoA metabolic process//fatty acid beta-oxidation GO:0003997//GO:0003723//GO:0005515 acyl-CoA oxidase activity//RNA binding//protein binding GO:0016020//GO:0005777 membrane//peroxisome KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.45294 BP_3 63.94 1.05 3231 189237846 XP_974719.2 859 5.2e-89 PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|642924610|ref|XP_008194362.1| PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|270007960|gb|EFA04408.1| hypothetical protein TcasGA2_TC014707 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45295 BP_3 1220.53 54.97 1362 676470177 XP_009058769.1 210 3.9e-14 hypothetical protein LOTGIDRAFT_164025 [Lottia gigantea]>gi|556101791|gb|ESO90443.1| hypothetical protein LOTGIDRAFT_164025 [Lottia gigantea] -- -- -- -- -- K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 P02535 132 1.8e-06 Keratin, type I cytoskeletal 10 OS=Mus musculus GN=Krt10 PE=1 SV=3 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family GO:0008152 metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.45296 BP_3 6.46 0.53 879 676470177 XP_009058769.1 166 3.2e-09 hypothetical protein LOTGIDRAFT_164025 [Lottia gigantea]>gi|556101791|gb|ESO90443.1| hypothetical protein LOTGIDRAFT_164025 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45297 BP_3 2669.07 40.78 3446 642916726 XP_008192366.1 1461 8.7e-159 PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum]>gi|642916728|ref|XP_008192372.1| PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 141 4.1e-07 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45300 BP_3 554.09 8.49 3439 642913381 XP_008195471.1 796 1.1e-81 PREDICTED: double-strand-break repair protein rad21 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 284 1.1e-23 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF04824 Conserved region of Rad21 / Rec8 like protein -- -- -- -- GO:0000228 nuclear chromosome KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.45301 BP_3 905.91 13.80 3455 189234473 XP_001808764.1 796 1.1e-81 PREDICTED: double-strand-break repair protein rad21 homolog isoform X1 [Tribolium castaneum]>gi|270002814|gb|EEZ99261.1| rad21 [Tribolium castaneum] -- -- -- -- -- K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 282 1.8e-23 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF04824 Conserved region of Rad21 / Rec8 like protein -- -- -- -- GO:0000228 nuclear chromosome KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.45302 BP_3 1385.39 23.09 3184 332372624 AEE61454.1 1753 1.1e-192 unknown [Dendroctonus ponderosae] 645007963 XM_008205563.1 265 7.02136e-134 PREDICTED: Nasonia vitripennis SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (LOC100118240), transcript variant X4, mRNA K11648 SMARCB1, SNF5, INI1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11648 Q6DFM1 1331 3.9e-145 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xenopus tropicalis GN=smarcb1 PE=2 SV=1 PF08039//PF04855 Mitochondrial proteolipid//SNF5 / SMARCB1 / INI1 GO:0006338 chromatin remodeling -- -- GO:0005739//GO:0000228 mitochondrion//nuclear chromosome KOG1649 SWI-SNF chromatin remodeling complex, Snf5 subunit Cluster-8309.45306 BP_3 470.39 4.98 4840 -- -- -- -- -- 642912444 XM_008202641.1 364 0 PREDICTED: Tribolium castaneum serum response factor (Srf), transcript variant X1, mRNA K04378 SRF serum response factor http://www.genome.jp/dbget-bin/www_bget?ko:K04378 Q3SXZ3 139 9.9e-07 Zinc finger protein 718 OS=Homo sapiens GN=ZNF718 PE=2 SV=1 PF13465//PF00096//PF00319//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//SRF-type transcription factor (DNA-binding and dimerisation domain)//C2H2-type zinc finger -- -- GO:0003677//GO:0046872//GO:0046983 DNA binding//metal ion binding//protein dimerization activity -- -- -- -- Cluster-8309.45307 BP_3 746.92 10.91 3592 617660946 XP_007537349.1 202 8.8e-13 PREDICTED: zinc finger protein 850-like [Erinaceus europaeus] -- -- -- -- -- -- -- -- -- O75346 197 1.4e-13 Zinc finger protein 253 OS=Homo sapiens GN=ZNF253 PE=2 SV=2 PF02892//PF13912//PF00433//PF05191//PF13465//PF06689//PF00096//PF01155 BED zinc finger//C2H2-type zinc finger//Protein kinase C terminal domain//Adenylate kinase, active site lid//Zinc-finger double domain//ClpX C4-type zinc finger//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0016310//GO:0006144//GO:0046034//GO:0006468//GO:0009069//GO:0006464 phosphorylation//purine nucleobase metabolic process//ATP metabolic process//protein phosphorylation//serine family amino acid metabolic process//cellular protein modification process GO:0016151//GO:0046983//GO:0003677//GO:0005524//GO:0046872//GO:0004674//GO:0004017//GO:0008270 nickel cation binding//protein dimerization activity//DNA binding//ATP binding//metal ion binding//protein serine/threonine kinase activity//adenylate kinase activity//zinc ion binding -- -- -- -- Cluster-8309.45309 BP_3 810.05 12.21 3489 642918994 XP_008191690.1 2383 1.1e-265 PREDICTED: tyrosine-protein kinase Btk29A isoform X3 [Tribolium castaneum] 642918993 XM_008193468.1 455 0 PREDICTED: Tribolium castaneum tyrosine-protein kinase Btk29A (LOC663266), transcript variant X3, mRNA K07364 TEC tyrosine-protein kinase Tec http://www.genome.jp/dbget-bin/www_bget?ko:K07364 P08630 1986 4.8e-221 Tyrosine-protein kinase Btk29A OS=Drosophila melanogaster GN=Btk29A PE=2 SV=2 PF00069//PF14604//PF00018//PF07714 Protein kinase domain//Variant SH3 domain//SH3 domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.45311 BP_3 190.68 2.27 4338 642918982 XP_008191684.1 4714 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.3512e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.45312 BP_3 598.79 7.78 4001 642932100 XP_008196854.1 1751 2.4e-192 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 642932099 XM_008198632.1 549 0 PREDICTED: Tribolium castaneum SPRY domain-containing SOCS box protein 1 (LOC664070), transcript variant X2, mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 5.1e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF07525//PF00622 SOCS box//SPRY domain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.45313 BP_3 369.59 7.37 2709 642928561 XP_008199958.1 1050 3.1e-111 PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928563|ref|XP_008199959.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928565|ref|XP_008199960.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270011133|gb|EFA07581.1| cytochrome P450 12H1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 O18635 743 5.1e-77 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0016705//GO:0005488 heme binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding -- -- -- -- Cluster-8309.45316 BP_3 1.00 6.78 254 705675810 XP_010116797.1 158 7.8e-09 PREDICTED: LOW QUALITY PROTEIN: ankyrin-1-like, partial [Chlamydotis macqueenii] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 P16157 148 4.6e-09 Ankyrin-1 OS=Homo sapiens GN=ANK1 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45318 BP_3 305.58 22.76 939 642925845 XP_008190534.1 669 1.6e-67 PREDICTED: mitogen-activated protein kinase-binding protein 1 isoform X3 [Tribolium castaneum] 642925848 XM_008192328.1 87 1.79872e-35 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45320 BP_3 587.55 30.18 1230 91077322 XP_974743.1 1310 1.0e-141 PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|642913792|ref|XP_008201162.1| PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|270002090|gb|EEZ98537.1| hypothetical protein TcasGA2_TC001041 [Tribolium castaneum] 632985180 XM_007911344.1 103 3.02827e-44 PREDICTED: Callorhinchus milii pre-mRNA processing factor 18 (prpf18), mRNA K12817 PRPF18, PRP18 pre-mRNA-splicing factor 18 http://www.genome.jp/dbget-bin/www_bget?ko:K12817 Q8BM39 859 8.1e-91 Pre-mRNA-splicing factor 18 OS=Mus musculus GN=Prpf18 PE=2 SV=1 PF02840 Prp18 domain GO:0008380 RNA splicing -- -- GO:0005681 spliceosomal complex KOG2808 U5 snRNP-associated RNA splicing factor Cluster-8309.45322 BP_3 1618.15 35.14 2511 642930006 XP_008196062.1 318 2.2e-26 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 7.6e-19 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.45324 BP_3 1550.88 8.96 8638 642930272 XP_008196325.1 3813 0.0e+00 PREDICTED: AT-rich interactive domain-containing protein 4B isoform X1 [Tribolium castaneum] -- -- -- -- -- K19195 ARID4B AT-rich interactive domain-containing protein 4B http://www.genome.jp/dbget-bin/www_bget?ko:K19195 Q4LE39 739 4.7e-76 AT-rich interactive domain-containing protein 4B OS=Homo sapiens GN=ARID4B PE=1 SV=2 PF01388 ARID/BRIGHT DNA binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.45325 BP_3 150.56 0.83 9079 642930272 XP_008196325.1 3820 0.0e+00 PREDICTED: AT-rich interactive domain-containing protein 4B isoform X1 [Tribolium castaneum] -- -- -- -- -- K19195 ARID4B AT-rich interactive domain-containing protein 4B http://www.genome.jp/dbget-bin/www_bget?ko:K19195 Q4LE39 739 4.9e-76 AT-rich interactive domain-containing protein 4B OS=Homo sapiens GN=ARID4B PE=1 SV=2 PF01388 ARID/BRIGHT DNA binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.45327 BP_3 149.56 1.60 4785 642914198 XP_008201586.1 2068 4.9e-229 PREDICTED: uncharacterized protein LOC661711 isoform X2 [Tribolium castaneum] 642914197 XM_008203364.1 384 0 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.9e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF15360//PF00018//PF07647//PF00536 APJ endogenous ligand//SH3 domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0007165 signal transduction GO:0005179//GO:0005515//GO:0031704 hormone activity//protein binding//apelin receptor binding -- -- -- -- Cluster-8309.45329 BP_3 6.09 1.10 558 642932128 XP_975308.3 183 2.2e-11 PREDICTED: monocarboxylate transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01213//PF00684 Adenylate cyclase associated (CAP) N terminal//DnaJ central domain GO:0007010 cytoskeleton organization GO:0003779//GO:0031072//GO:0051082 actin binding//heat shock protein binding//unfolded protein binding -- -- -- -- Cluster-8309.45331 BP_3 8480.60 117.69 3765 478249931 ENN70438.1 943 1.1e-98 hypothetical protein YQE_12942, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9IBG7 163 1.3e-09 Kielin/chordin-like protein OS=Xenopus laevis GN=kcp PE=2 SV=1 PF00093//PF00216 von Willebrand factor type C domain//Bacterial DNA-binding protein -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.45332 BP_3 51.52 0.32 7997 546684848 ERL94430.1 1978 2.3e-218 hypothetical protein D910_11707 [Dendroctonus ponderosae] 462302391 APGK01050245.1 46 9.78571e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 Q2M2R8 872 1.6e-91 Peroxisomal targeting signal 1 receptor OS=Rattus norvegicus GN=Pex5 PE=1 SV=2 PF00400//PF13371//PF13374//PF00515//PF13414//PF13176//PF02064//PF00638//PF13181 WD domain, G-beta repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//MAS20 protein import receptor//RanBP1 domain//Tetratricopeptide repeat GO:0006605//GO:0006886//GO:0046907 protein targeting//intracellular protein transport//intracellular transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.45333 BP_3 304.53 1.97 7740 642935862 XP_008198202.1 2012 2.5e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 9.46976e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 4.0e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF00515//PF13374//PF13371//PF00400//PF13176//PF13414//PF13181//PF00638//PF02064 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//RanBP1 domain//MAS20 protein import receptor GO:0006605//GO:0006886//GO:0046907 protein targeting//intracellular protein transport//intracellular transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.45334 BP_3 61.44 0.40 7757 642935862 XP_008198202.1 2012 2.5e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 9.49066e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 4.0e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF13181//PF00638//PF02064//PF13414//PF13176//PF00400//PF00515//PF13374//PF13371 Tetratricopeptide repeat//RanBP1 domain//MAS20 protein import receptor//TPR repeat//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006886//GO:0046907//GO:0006605 intracellular protein transport//intracellular transport//protein targeting GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.45336 BP_3 489.33 12.03 2252 642923358 XP_008193717.1 657 9.6e-66 PREDICTED: serine/threonine-protein phosphatase 1 regulatory subunit 10-like [Tribolium castaneum]>gi|270007046|gb|EFA03494.1| hypothetical protein TcasGA2_TC013494 [Tribolium castaneum] -- -- -- -- -- K17552 PPP1R10 protein phosphatase 1 regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K17552 Q6GLQ4 298 1.7e-25 Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Xenopus laevis GN=ppp1r10 PE=2 SV=1 PF04006//PF00642//PF05297 Mpp10 protein//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Herpesvirus latent membrane protein 1 (LMP1) GO:0006364//GO:0019087//GO:0006351 rRNA processing//transformation of host cell by virus//transcription, DNA-templated GO:0008270//GO:0046872//GO:0003677 zinc ion binding//metal ion binding//DNA binding GO:0005732//GO:0034457//GO:0016021//GO:0005634 small nucleolar ribonucleoprotein complex//Mpp10 complex//integral component of membrane//nucleus -- -- Cluster-8309.45338 BP_3 20.16 0.41 2681 270008906 EFA05354.1 1818 2.7e-200 hypothetical protein TcasGA2_TC015519 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1607 3.3e-177 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF02934//PF00087//PF00654 GatB/GatE catalytic domain//Snake toxin//Voltage gated chloride channel GO:0006821//GO:0009405//GO:0055085 chloride transport//pathogenesis//transmembrane transport GO:0016874//GO:0005247 ligase activity//voltage-gated chloride channel activity GO:0005576//GO:0016020 extracellular region//membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.45341 BP_3 391.00 8.35 2549 270015207 EFA11655.1 1074 4.8e-114 hypothetical protein TcasGA2_TC004080 [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 A6QNP3 340 2.6e-30 Protein phosphatase 1 regulatory subunit 3B OS=Bos taurus GN=PPP1R3B PE=2 SV=1 PF03370//PF16760 Carbohydrate/starch-binding module (family 21)//Starch/carbohydrate-binding module (family 53) -- -- GO:0005515//GO:2001070 protein binding//starch binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.45342 BP_3 1.00 1.10 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45345 BP_3 1085.71 23.82 2489 91094425 XP_969302.1 1958 1.5e-216 PREDICTED: host cell factor 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q9V4C8 625 2.2e-63 Host cell factor OS=Drosophila melanogaster GN=Hcf PE=1 SV=2 PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.45346 BP_3 1180.36 17.20 3600 642939156 XP_008200359.1 1312 1.7e-141 PREDICTED: host cell factor 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 P51611 613 8.0e-62 Host cell factor 1 OS=Mesocricetus auratus GN=HCFC1 PE=1 SV=1 PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.45347 BP_3 6.61 0.36 1184 642924888 XP_008194085.1 461 2.7e-43 PREDICTED: nibrin [Tribolium castaneum] -- -- -- -- -- K10867 NBN, NBS1 nijmegen breakage syndrome protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10867 Q5I2W8 362 3.3e-33 Nibrin OS=Danio rerio GN=nbn PE=2 SV=2 PF00498 FHA domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45348 BP_3 8.93 0.54 1089 642916357 XP_008190987.1 414 7.0e-38 PREDICTED: ubiquitin domain-containing protein UBFD1 isoform X1 [Tribolium castaneum] 769860810 XM_011643855.1 35 1.69125e-06 PREDICTED: Pogonomyrmex barbatus ubiquitin domain-containing protein UBFD1-like (LOC105430337), transcript variant X3, mRNA -- -- -- -- O14562 267 3.2e-22 Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens GN=UBFD1 PE=1 SV=2 PF15323//PF00240 Developmental protein//Ubiquitin family GO:0048598 embryonic morphogenesis GO:0005515 protein binding GO:0072669 tRNA-splicing ligase complex -- -- Cluster-8309.4535 BP_3 1.00 12.65 237 765144722 XP_011483321.1 178 3.5e-11 PREDICTED: transposase isoform X1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45350 BP_3 382.28 3.62 5383 642911937 XP_008199029.1 3902 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 585 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1858 5.1e-206 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF03114//PF00018//PF00023//PF14604//PF07043//PF08397//PF13606//PF00465//PF01412 BAR domain//SH3 domain//Ankyrin repeat//Variant SH3 domain//Protein of unknown function (DUF1328)//IRSp53/MIM homology domain//Ankyrin repeat//Iron-containing alcohol dehydrogenase//Putative GTPase activating protein for Arf GO:0007009//GO:0055114 plasma membrane organization//oxidation-reduction process GO:0046872//GO:0005096//GO:0005515//GO:0016491 metal ion binding//GTPase activator activity//protein binding//oxidoreductase activity GO:0005737//GO:0005886 cytoplasm//plasma membrane -- -- Cluster-8309.45351 BP_3 820.26 3.16 12820 642926407 XP_008191950.1 4387 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.1419e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.6e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF00046//PF10541//PF02376//PF05920//PF03325//PF03699//PF02121 Homeobox domain//Nuclear envelope localisation domain//CUT domain//Homeobox KN domain//Herpesvirus polymerase accessory protein//Uncharacterised protein family (UPF0182)//Phosphatidylinositol transfer protein GO:0006260//GO:0006355//GO:0019079//GO:0006810 DNA replication//regulation of transcription, DNA-templated//viral genome replication//transport GO:0003677//GO:0030337 DNA binding//DNA polymerase processivity factor activity GO:0005622//GO:0016021//GO:0042575 intracellular//integral component of membrane//DNA polymerase complex KOG3668 Phosphatidylinositol transfer protein Cluster-8309.45353 BP_3 720.17 8.90 4190 91077046 XP_968112.1 1016 4.2e-107 PREDICTED: ras-related C3 botulinum toxin substrate 1 [Tribolium castaneum]>gi|270002813|gb|EEZ99260.1| Mig-2-like protein [Tribolium castaneum] 746848885 XM_011056563.1 186 7.63327e-90 PREDICTED: Acromyrmex echinatior ras-related C3 botulinum toxin substrate 1 (LOC105146367), mRNA K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 P62999 770 5.8e-80 Ras-related C3 botulinum toxin substrate 1 OS=Canis familiaris GN=RAC1 PE=2 SV=1 PF08477//PF15894//PF05656//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Inhibitor of glucose uptake transporter SgrT//Protein of unknown function (DUF805)//ADP-ribosylation factor family//Ras family GO:0007264//GO:0046325 small GTPase mediated signal transduction//negative regulation of glucose import GO:0005525 GTP binding GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular KOG0393 Ras-related small GTPase, Rho type Cluster-8309.45354 BP_3 21.24 0.51 2303 478264640 ENN82297.1 723 2.2e-73 hypothetical protein YQE_01327, partial [Dendroctonus ponderosae] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 343 1.0e-30 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.45355 BP_3 734.91 37.67 1232 642937410 XP_008198824.1 862 8.9e-90 PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|642937412|ref|XP_008198826.1| PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|270000810|gb|EEZ97257.1| hypothetical protein TcasGA2_TC011057 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 380 2.8e-35 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0046486//GO:0008654//GO:0042967//GO:0008152 glycerolipid metabolic process//phospholipid biosynthetic process//acyl-carrier-protein biosynthetic process//metabolic process GO:0016746//GO:0003841 transferase activity, transferring acyl groups//1-acylglycerol-3-phosphate O-acyltransferase activity GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.45357 BP_3 475.66 9.70 2655 642917087 XP_008191111.1 1264 4.7e-136 PREDICTED: probable ATP-dependent RNA helicase DDX20 [Tribolium castaneum]>gi|270004341|gb|EFA00789.1| hypothetical protein TcasGA2_TC003675 [Tribolium castaneum] -- -- -- -- -- K13131 DDX20, GEMIN3 ATP-dependent RNA helicase DDX20 http://www.genome.jp/dbget-bin/www_bget?ko:K13131 P0C218 932 6.0e-99 Probable ATP-dependent RNA helicase DDX20 OS=Danio rerio GN=ddx20 PE=3 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0004386//GO:0000166//GO:0005524//GO:0003677//GO:0016787//GO:0003676 helicase activity//nucleotide binding//ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- -- -- Cluster-8309.45358 BP_3 45.17 0.62 3804 642923667 XP_008193834.1 2088 1.9e-231 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 Q54LE6 639 8.2e-65 ABC transporter C family member 5 OS=Dictyostelium discoideum GN=abcC5 PE=3 SV=1 PF00664//PF13304//PF01926//PF00005//PF03193 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.45361 BP_3 308.77 1.98 7815 642936590 XP_008198497.1 1461 2.0e-158 PREDICTED: uncharacterized protein LOC103314369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 255 5.6e-20 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF05375//PF15686 Pacifastin inhibitor (LCMII)//Lysine-rich CEACAM1 co-isolated protein family GO:0045766//GO:0043123//GO:0043066 positive regulation of angiogenesis//positive regulation of I-kappaB kinase/NF-kappaB signaling//negative regulation of apoptotic process GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.45362 BP_3 64.63 0.58 5696 642925023 XP_008194140.1 3709 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X4 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.96036e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.8e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.45363 BP_3 188.80 4.12 2498 642916810 XP_967695.2 1570 1.4e-171 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 1086 7.9e-117 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein GO:0050821//GO:0015979 protein stabilization//photosynthesis GO:0042301//GO:0005515 phosphate ion binding//protein binding GO:0016020//GO:0009523 membrane//photosystem II KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.45365 BP_3 783.06 14.43 2908 642935358 XP_008197980.1 1397 1.9e-151 PREDICTED: uncharacterized protein LOC657906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E9QJ05 145 1.2e-07 Protein PET117 homolog, mitochondrial OS=Danio rerio GN=pet117 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45367 BP_3 950.00 30.08 1814 332376085 AEE63183.1 1974 1.5e-218 unknown [Dendroctonus ponderosae]>gi|478254813|gb|ENN75049.1| hypothetical protein YQE_08364, partial [Dendroctonus ponderosae]>gi|546676901|gb|ERL87825.1| hypothetical protein D910_05214 [Dendroctonus ponderosae] 642925677 XM_969308.2 332 2.25738e-171 PREDICTED: Tribolium castaneum ruvB-like 2 (LOC663252), mRNA K11338 RUVBL2, RVB2, INO80J RuvB-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11338 Q9DE27 1665 4.1e-184 RuvB-like 2 OS=Xenopus laevis GN=ruvbl2 PE=2 SV=1 PF06414//PF02367//PF02562//PF00910//PF06068//PF00158//PF03796//PF05496//PF07728//PF01695//PF00004 Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//RNA helicase//TIP49 C-terminus//Sigma-54 interaction domain//DnaB-like helicase C terminal domain//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//ATPase family associated with various cellular activities (AAA) GO:0006260//GO:0006355//GO:0006281//GO:0006310//GO:0002949 DNA replication//regulation of transcription, DNA-templated//DNA repair//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0016887//GO:0016301//GO:0005524//GO:0008134//GO:0003724//GO:0009378//GO:0003723//GO:0003678 ATPase activity//kinase activity//ATP binding//transcription factor binding//RNA helicase activity//four-way junction helicase activity//RNA binding//DNA helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG2680 DNA helicase TIP49, TBP-interacting protein Cluster-8309.45368 BP_3 248.59 0.99 12396 642913916 XP_008201212.1 3044 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X1 [Tribolium castaneum] 755870656 XM_005181954.2 137 3.93587e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 P51812 2107 1.6e-234 Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1 PF00069//PF06293//PF07714//PF00433 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Protein kinase C terminal domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.45369 BP_3 65.29 1.26 2784 478253945 ENN74237.1 863 1.5e-89 hypothetical protein YQE_09210, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BJM3 303 5.5e-26 Coiled-coil domain-containing protein R3HCC1L OS=Mus musculus GN=R3hcc1l PE=2 SV=1 PF08675//PF06963 RNA binding domain//Ferroportin1 (FPN1) GO:0006826//GO:0051252//GO:0034755//GO:0006402 iron ion transport//regulation of RNA metabolic process//iron ion transmembrane transport//mRNA catabolic process GO:0004535//GO:0005381//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//iron ion transmembrane transporter activity//metal ion binding//RNA binding GO:0005737//GO:0016021//GO:0005634 cytoplasm//integral component of membrane//nucleus KOG4483 Uncharacterized conserved protein Cluster-8309.45371 BP_3 875.00 7.13 6204 91094947 XP_968721.1 2301 6.2e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- KOG2432 Uncharacterized conserved protein Cluster-8309.45374 BP_3 473.17 4.71 5130 642925748 XP_008201596.1 549 7.3e-53 PREDICTED: uncharacterized protein LOC103315223 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03967 Photosynthetic reaction centre, H-chain N-terminal region GO:0006118//GO:0019684 obsolete electron transport//photosynthesis, light reaction GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GO:0030077 plasma membrane light-harvesting complex -- -- Cluster-8309.45375 BP_3 12.06 15.04 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45376 BP_3 107.09 0.90 6050 642938527 XP_008199828.1 2530 1.7e-282 PREDICTED: actin-related protein 8 [Tribolium castaneum] 642927958 XR_511541.1 53 9.49949e-16 PREDICTED: Tribolium castaneum transcriptional adapter 2B (LOC663682), transcript variant X2, misc_RNA K11673 ACTR8, ARP8, INO80N actin-related protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11673 Q0IEG8 1666 1.1e-183 Actin-related protein 8 OS=Aedes aegypti GN=Arp8 PE=3 SV=1 PF04433//PF00569//PF06723 SWIRM domain//Zinc finger, ZZ type//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0797 Actin-related protein Cluster-8309.45377 BP_3 228.92 1.99 5824 642938527 XP_008199828.1 2530 1.6e-282 PREDICTED: actin-related protein 8 [Tribolium castaneum] 642927958 XR_511541.1 53 9.14251e-16 PREDICTED: Tribolium castaneum transcriptional adapter 2B (LOC663682), transcript variant X2, misc_RNA K11673 ACTR8, ARP8, INO80N actin-related protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11673 Q0IEG8 1666 1.0e-183 Actin-related protein 8 OS=Aedes aegypti GN=Arp8 PE=3 SV=1 PF06723//PF00569//PF04433 MreB/Mbl protein//Zinc finger, ZZ type//SWIRM domain GO:0000902 cell morphogenesis GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0797 Actin-related protein Cluster-8309.45386 BP_3 96.76 0.77 6366 270002146 EEZ98593.1 7002 0.0e+00 hypothetical protein TcasGA2_TC001109 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9QWN8 1711 6.8e-189 Spectrin beta chain, non-erythrocytic 2 OS=Rattus norvegicus GN=Sptbn2 PE=1 SV=2 PF00307//PF14604//PF00018//PF00642//PF00435 Calponin homology (CH) domain//Variant SH3 domain//SH3 domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Spectrin repeat -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.45387 BP_3 55.71 0.47 6061 642928531 XP_008195362.1 3020 0.0e+00 PREDICTED: transient receptor potential channel pyrexia [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 1952 7.3e-217 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF07992//PF00023//PF01266//PF13606//PF00520//PF02254 Pyridine nucleotide-disulphide oxidoreductase//Ankyrin repeat//FAD dependent oxidoreductase//Ankyrin repeat//Ion transport protein//TrkA-N domain GO:0006811//GO:0055114//GO:0006813//GO:0055085 ion transport//oxidation-reduction process//potassium ion transport//transmembrane transport GO:0005216//GO:0005515//GO:0016491 ion channel activity//protein binding//oxidoreductase activity GO:0016020 membrane KOG4177 Ankyrin Cluster-8309.45388 BP_3 1220.00 7.73 7899 642937363 XP_008198806.1 4646 0.0e+00 PREDICTED: ATP-dependent helicase brm isoform X1 [Tribolium castaneum]>gi|642937365|ref|XP_008198807.1| PREDICTED: ATP-dependent helicase brm isoform X1 [Tribolium castaneum] 801398653 XM_012204404.1 479 0 PREDICTED: Atta cephalotes ATP-dependent helicase brm (LOC105623001), mRNA K11647 SMARCA2_4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K11647 P25439 3883 0.0e+00 ATP-dependent helicase brm OS=Drosophila melanogaster GN=brm PE=1 SV=2 PF00176//PF04851//PF00270//PF13892//PF02935//PF14619//PF07533//PF00439//PF08880 SNF2 family N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//DNA-binding domain//Cytochrome c oxidase subunit VIIc//Snf2-ATP coupling, chromatin remodelling complex//BRK domain//Bromodomain//QLQ GO:0006355//GO:0015992//GO:0006123 regulation of transcription, DNA-templated//proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0042393//GO:0003676//GO:0004129//GO:0016817//GO:0005524//GO:0016787//GO:0003677//GO:0005515 histone binding//nucleic acid binding//cytochrome-c oxidase activity//hydrolase activity, acting on acid anhydrides//ATP binding//hydrolase activity//DNA binding//protein binding GO:0005634//GO:0045277 nucleus//respiratory chain complex IV KOG0386 Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) Cluster-8309.45389 BP_3 1423.51 12.74 5679 642915716 XP_008190773.1 4756 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X4 [Tribolium castaneum] 752876735 XM_011257478.1 63 2.46081e-21 PREDICTED: Camponotus floridanus rho guanine nucleotide exchange factor 12 (LOC105251006), transcript variant X6, mRNA K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.9e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF09128//PF00130//PF13180//PF00595//PF00621 Regulator of G protein signalling-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//PDZ domain//PDZ domain (Also known as DHR or GLGF)//RhoGEF domain GO:0043087//GO:0035023//GO:0035556 regulation of GTPase activity//regulation of Rho protein signal transduction//intracellular signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding GO:0005737 cytoplasm KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.4539 BP_3 2.00 0.42 520 118083604 XP_416616.2 557 8.7e-55 PREDICTED: 60S ribosomal protein L24 [Gallus gallus]>gi|527266977|ref|XP_005151635.1| PREDICTED: 60S ribosomal protein L24 [Melopsittacus undulatus]>gi|729738889|ref|XP_010565634.1| PREDICTED: 60S ribosomal protein L24 [Haliaeetus leucocephalus]>gi|733872175|ref|XP_010718751.1| PREDICTED: 60S ribosomal protein L24 [Meleagris gallopavo]>gi|768340933|ref|XP_011582962.1| PREDICTED: 60S ribosomal protein L24 [Aquila chrysaetos canadensis] 694903177 XM_009446072.1 520 0 PREDICTED: Pan troglodytes ribosomal protein L24 (RPL24), mRNA K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q6Y263 533 2.2e-53 60S ribosomal protein L24 OS=Pagrus major GN=rpl24 PE=2 SV=1 PF07565 Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1722 60s ribosomal protein L24 Cluster-8309.45391 BP_3 23.24 0.33 3659 642927046 XP_008195117.1 1366 9.5e-148 PREDICTED: putative ATP-dependent RNA helicase DHX30 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13185 DHX30 ATP-dependent RNA helicase DHX30 http://www.genome.jp/dbget-bin/www_bget?ko:K13185 Q6PGC1 758 1.2e-78 ATP-dependent RNA helicase Dhx29 OS=Mus musculus GN=Dhx29 PE=2 SV=1 PF03193//PF04408//PF00270 Protein of unknown function, DUF258//Helicase associated domain (HA2)//DEAD/DEAH box helicase -- -- GO:0003924//GO:0003676//GO:0004386//GO:0005524//GO:0005525 GTPase activity//nucleic acid binding//helicase activity//ATP binding//GTP binding -- -- -- -- Cluster-8309.45393 BP_3 793.15 5.65 7052 189239223 XP_973572.2 678 1.1e-67 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 1.31629e-74 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF05115 Cytochrome B6-F complex subunit VI (PetL) GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.45395 BP_3 74.44 0.43 8601 91082383 XP_968748.1 3389 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.36191e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2467 2.0e-276 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00437//PF00664//PF13304//PF00158//PF01926//PF01580//PF00931//PF00005//PF03266//PF03193//PF01637//PF02367//PF06414 Type II/IV secretion system protein//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Sigma-54 interaction domain//50S ribosome-binding GTPase//FtsK/SpoIIIE family//NB-ARC domain//ABC transporter//NTPase//Protein of unknown function, DUF258//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin GO:0006810//GO:0055085//GO:0006355//GO:0002949 transport//transmembrane transport//regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0003924//GO:0098519//GO:0005524//GO:0042626//GO:0016887//GO:0016301//GO:0000166//GO:0043531//GO:0003677//GO:0017111//GO:0005525 transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//nucleotide binding//ADP binding//DNA binding//nucleoside-triphosphatase activity//GTP binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.45396 BP_3 1072.00 4.69 11302 642920962 XP_008192632.1 910 2.2e-94 PREDICTED: uncharacterized protein LOC103312136 [Tribolium castaneum]>gi|642920964|ref|XP_008192633.1| PREDICTED: uncharacterized protein LOC103312136 [Tribolium castaneum]>gi|270005145|gb|EFA01593.1| hypothetical protein TcasGA2_TC007157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45397 BP_3 515.00 46.20 829 642924825 XP_967668.2 738 1.4e-75 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I922 290 5.2e-25 Regucalcin OS=Xenopus laevis GN=rgn PE=2 SV=1 PF01731 Arylesterase -- -- GO:0004064 arylesterase activity -- -- -- -- Cluster-8309.45398 BP_3 77.81 0.86 4654 91076340 XP_971067.1 1806 1.2e-198 PREDICTED: peroxisomal N(1)-acetyl-spermine/spermidine oxidase [Tribolium castaneum]>gi|270002541|gb|EEZ98988.1| hypothetical protein TcasGA2_TC004849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q865R1 602 1.9e-60 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus GN=PAOX PE=1 SV=3 PF01593//PF01134//PF06100//PF01494//PF07992//PF01266//PF00979 Flavin containing amine oxidoreductase//Glucose inhibited division protein A//MCRA family//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Reovirus outer capsid protein, Sigma 3 GO:0019058//GO:0055114//GO:0008033//GO:0006631 viral life cycle//oxidation-reduction process//tRNA processing//fatty acid metabolic process GO:0050151//GO:0005198//GO:0016491//GO:0071949//GO:0050660 oleate hydratase activity//structural molecule activity//oxidoreductase activity//FAD binding//flavin adenine dinucleotide binding -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.45399 BP_3 107.25 3.31 1852 642936637 XP_008198518.1 1491 1.5e-162 PREDICTED: zinc finger and BTB domain-containing protein 12 [Tribolium castaneum] 642936636 XM_008200296.1 101 5.95628e-43 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 12 (LOC661906), mRNA -- -- -- -- Q01295 398 3.5e-37 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45400 BP_3 60.97 1.02 3171 167234455 NP_001107843.1 1160 6.4e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.9e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45401 BP_3 308.61 4.38 3688 568248634 ETN58473.1 1038 1.0e-109 Elongation of very long chain fatty acids protein [Anopheles darlingi] 642935170 XM_008201454.1 67 9.51723e-24 PREDICTED: Tribolium castaneum elongation of very long chain fatty acids protein AAEL008004 (LOC655397), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 723 1.4e-74 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45402 BP_3 93.88 2.27 2284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45403 BP_3 37.77 0.56 3543 642926809 XP_008195022.1 416 1.3e-37 PREDICTED: zinc finger protein 64 homolog, isoforms 3 and 4-like [Tribolium castaneum]>gi|270009173|gb|EFA05621.1| hypothetical protein TcasGA2_TC015829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PVG3 262 3.9e-21 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF01465//PF07776//PF04120//PF13465//PF01309//PF00096 GRIP domain//Zinc-finger associated domain (zf-AD)//Low affinity iron permease//Zinc-finger double domain//Equine arteritis virus small envelope glycoprotein//Zinc finger, C2H2 type GO:0000042//GO:0055085 protein targeting to Golgi//transmembrane transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0019031//GO:0005634 viral envelope//nucleus -- -- Cluster-8309.45404 BP_3 132.37 5.59 1433 91092260 XP_967199.1 755 2.6e-77 PREDICTED: uncharacterized protein C6orf136 [Tribolium castaneum]>gi|270001227|gb|EEZ97674.1| hypothetical protein TcasGA2_TC016219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SQH8 260 2.7e-21 Uncharacterized protein C6orf136 OS=Homo sapiens GN=C6orf136 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4457 Uncharacterized conserved protein Cluster-8309.45406 BP_3 600.50 2.97 10022 642917699 XP_008191335.1 2161 1.7e-239 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X5 [Tribolium castaneum] 817189456 XM_012414634.1 313 4.61897e-160 PREDICTED: Orussus abietinus mitogen-activated protein kinase kinase kinase kinase 5 (LOC105694191), transcript variant X5, mRNA K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q8IVH8 1310 3.3e-142 Mitogen-activated protein kinase kinase kinase kinase 3 OS=Homo sapiens GN=MAP4K3 PE=1 SV=1 PF07728//PF00069//PF07714//PF01926//PF00004//PF00437//PF00005//PF03193//PF03266//PF01637//PF00503//PF00910//PF01580 AAA domain (dynein-related subfamily)//Protein kinase domain//Protein tyrosine kinase//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//ABC transporter//Protein of unknown function, DUF258//NTPase//Archaeal ATPase//G-protein alpha subunit//RNA helicase//FtsK/SpoIIIE family GO:0006468//GO:0006810//GO:0007165//GO:0007186 protein phosphorylation//transport//signal transduction//G-protein coupled receptor signaling pathway GO:0003723//GO:0003677//GO:0003724//GO:0004672//GO:0005525//GO:0004871//GO:0003924//GO:0005524//GO:0098519//GO:0031683//GO:0000166//GO:0016887//GO:0019001 RNA binding//DNA binding//RNA helicase activity//protein kinase activity//GTP binding//signal transducer activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//G-protein beta/gamma-subunit complex binding//nucleotide binding//ATPase activity//guanyl nucleotide binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45408 BP_3 2068.62 19.24 5474 642913045 XP_008201364.1 6725 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35556 3609 0.0e+00 Fibrillin-2 OS=Homo sapiens GN=FBN2 PE=1 SV=3 PF09064//PF07645//PF00008 Thrombomodulin like fifth domain, EGF-like//Calcium-binding EGF domain//EGF-like domain GO:0007165 signal transduction GO:0005509//GO:0004888//GO:0005515 calcium ion binding//transmembrane signaling receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.45409 BP_3 37.84 0.35 5554 642913045 XP_008201364.1 4060 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35556 2139 1.4e-238 Fibrillin-2 OS=Homo sapiens GN=FBN2 PE=1 SV=3 PF00008//PF07645//PF06247//PF09064 EGF-like domain//Calcium-binding EGF domain//Plasmodium ookinete surface protein Pvs28//Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888//GO:0005509//GO:0005515 transmembrane signaling receptor activity//calcium ion binding//protein binding GO:0009986//GO:0016021//GO:0016020 cell surface//integral component of membrane//membrane -- -- Cluster-8309.45410 BP_3 159.69 6.76 1431 546673062 ERL84739.1 984 7.4e-104 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 453 1.1e-43 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF03583//PF01764//PF00326//PF07859//PF02230 Secretory lipase//Lipase (class 3)//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase GO:0046486//GO:0016042//GO:0006508//GO:0006629//GO:0008152 glycerolipid metabolic process//lipid catabolic process//proteolysis//lipid metabolic process//metabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.45411 BP_3 98.60 2.88 1941 546673062 ERL84739.1 984 1.0e-103 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 453 1.5e-43 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF03583//PF11112//PF01764//PF02230//PF07859//PF00326 Secretory lipase//Pyocin activator protein PrtN//Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0016042//GO:0006355//GO:0046486//GO:0008152//GO:0006629 proteolysis//lipid catabolic process//regulation of transcription, DNA-templated//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0008236//GO:0016787//GO:0004806 serine-type peptidase activity//hydrolase activity//triglyceride lipase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.45412 BP_3 31.51 6.71 518 478250471 ENN70966.1 337 2.8e-29 hypothetical protein YQE_12367, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AYT7 136 2.3e-07 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45413 BP_3 12.68 0.46 1634 270013283 EFA09731.1 335 1.5e-28 hypothetical protein TcasGA2_TC011864 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35566 193 1.8e-13 CD151 antigen OS=Mus musculus GN=Cd151 PE=2 SV=2 PF00335//PF02203 Tetraspanin family//Tar ligand binding domain homologue GO:0006935//GO:0007165 chemotaxis//signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.45415 BP_3 51.76 6.16 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45416 BP_3 673.85 11.71 3066 91090560 XP_971544.1 1549 4.8e-169 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013348|gb|EFA09796.1| hypothetical protein TcasGA2_TC011938 [Tribolium castaneum] 751447204 XM_011179427.1 197 4.27386e-96 PREDICTED: Bactrocera cucurbitae elongation of very long chain fatty acids protein AAEL008004 (LOC105209165), transcript variant X2, mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1022 2.5e-109 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151//PF02554 GNS1/SUR4 family//Carbon starvation protein CstA GO:0009267 cellular response to starvation -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.45419 BP_3 32.24 3.72 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45421 BP_3 35.07 0.94 2096 91088863 XP_971818.1 142 4.7e-06 PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932389|ref|XP_008197091.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932391|ref|XP_008197092.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|270011591|gb|EFA08039.1| hypothetical protein TcasGA2_TC005632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45424 BP_3 1.00 0.58 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45425 BP_3 17.36 0.57 1749 642931893 XP_008196771.1 850 3.1e-88 PREDICTED: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 692 2.7e-71 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.45426 BP_3 7.05 0.91 664 22901764 AAN10061.1 297 1.6e-24 Kunitz-like protease inhibitor precursor [Ancylostoma caninum] -- -- -- -- -- K03909 TFPI tissue factor pathway inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K03909 P86733 283 2.7e-24 BPTI/Kunitz domain-containing protein (Fragment) OS=Haliotis asinina PE=1 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.45429 BP_3 25.47 1.14 1373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45430 BP_3 2.00 1.11 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45433 BP_3 269.84 3.57 3939 642927862 XP_008195429.1 2688 5.2e-301 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X2 [Tribolium castaneum]>gi|270009857|gb|EFA06305.1| hypothetical protein TcasGA2_TC009173 [Tribolium castaneum] 662183442 XM_008489250.1 153 1.58578e-71 PREDICTED: Diaphorina citri receptor-type tyrosine-protein phosphatase alpha (LOC103524239), mRNA K13297 PTPRT receptor-type tyrosine-protein phosphatase T http://www.genome.jp/dbget-bin/www_bget?ko:K13297 Q99M80 1006 2.3e-107 Receptor-type tyrosine-protein phosphatase T OS=Mus musculus GN=Ptprt PE=2 SV=2 PF00782//PF00641//PF00041//PF00102//PF07973 Dual specificity phosphatase, catalytic domain//Zn-finger in Ran binding protein and others//Fibronectin type III domain//Protein-tyrosine phosphatase//Threonyl and Alanyl tRNA synthetase second additional domain GO:0035335//GO:0043039//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//tRNA aminoacylation//protein dephosphorylation//tyrosine metabolic process GO:0008270//GO:0016876//GO:0005524//GO:0008138//GO:0005515//GO:0004725 zinc ion binding//ligase activity, forming aminoacyl-tRNA and related compounds//ATP binding//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.45434 BP_3 161.03 4.87 1884 642917693 XP_008191332.1 2257 2.4e-251 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q9Y4K4 1110 9.8e-120 Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens GN=MAP4K5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45435 BP_3 29.31 0.91 1845 642917699 XP_008191335.1 2220 4.5e-247 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X5 [Tribolium castaneum] -- -- -- -- -- K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q9Y4K4 1110 9.6e-120 Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens GN=MAP4K5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45436 BP_3 147.36 1.37 5467 642917699 XP_008191335.1 2220 1.3e-246 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X5 [Tribolium castaneum] -- -- -- -- -- K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q9Y4K4 1110 2.8e-119 Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens GN=MAP4K5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45438 BP_3 1070.88 8.60 6295 642916405 XP_008191009.1 2354 4.5e-262 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.6e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF03114//PF00018//PF14604 IRSp53/MIM homology domain//BAR domain//SH3 domain//Variant SH3 domain GO:0007009 plasma membrane organization GO:0005515 protein binding GO:0005737 cytoplasm -- -- Cluster-8309.45439 BP_3 3295.58 28.91 5787 642916405 XP_008191009.1 3474 0.0e+00 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.5e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF00018//PF14604 IRSp53/MIM homology domain//SH3 domain//Variant SH3 domain GO:0007009 plasma membrane organization GO:0005515 protein binding -- -- -- -- Cluster-8309.45440 BP_3 118.09 1.24 4885 642912121 XP_008200815.1 1303 2.6e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1R3 469 5.4e-45 StAR-related lipid transfer protein 7, mitochondrial OS=Mus musculus GN=Stard7 PE=2 SV=2 PF01494//PF07992//PF09452//PF01593//PF12831//PF01266//PF01134//PF01907//PF01852//PF08264 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//ESCRT-I subunit Mvb12//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Glucose inhibited division protein A//Ribosomal protein L37e//START domain//Anticodon-binding domain of tRNA GO:0032509//GO:0042254//GO:0055114//GO:0008033//GO:0006412//GO:0006418 endosome transport via multivesicular body sorting pathway//ribosome biogenesis//oxidation-reduction process//tRNA processing//translation//tRNA aminoacylation for protein translation GO:0071949//GO:0000166//GO:0003735//GO:0043130//GO:0008289//GO:0016491//GO:0050660 FAD binding//nucleotide binding//structural constituent of ribosome//ubiquitin binding//lipid binding//oxidoreductase activity//flavin adenine dinucleotide binding GO:0005840//GO:0005622//GO:0000813 ribosome//intracellular//ESCRT I complex KOG0685 Flavin-containing amine oxidase Cluster-8309.45441 BP_3 919.00 22.53 2258 270001642 EEZ98089.1 550 2.5e-53 hypothetical protein TcasGA2_TC000502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T3Y0 248 1.1e-19 Probable E3 ubiquitin-protein ligase sinah OS=Drosophila melanogaster GN=sinah PE=1 SV=2 PF03391//PF03145//PF02176 Nepovirus coat protein, central domain//Seven in absentia protein family//TRAF-type zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0005634//GO:0019028 nucleus//viral capsid KOG3002 Zn finger protein Cluster-8309.45444 BP_3 37.61 0.43 4514 642910200 XP_008198377.1 2265 6.7e-252 PREDICTED: N-alpha-acetyltransferase 35, NatC auxiliary subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZHV2 1540 3.2e-169 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Gallus gallus GN=NAA35 PE=2 SV=1 PF02050//PF08287//PF01442//PF08336 Flagellar FliJ protein//Spc19//Apolipoprotein A1/A4/E domain//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0006525//GO:0018401//GO:0055114//GO:0008608//GO:0006869//GO:0071973//GO:0006560//GO:0006935//GO:0042157 arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//oxidation-reduction process//attachment of spindle microtubules to kinetochore//lipid transport//bacterial-type flagellum-dependent cell motility//proline metabolic process//chemotaxis//lipoprotein metabolic process GO:0016702//GO:0004656//GO:0008289//GO:0003774 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//procollagen-proline 4-dioxygenase activity//lipid binding//motor activity GO:0005876//GO:0009288//GO:0042729//GO:0005783//GO:0005576//GO:0016020 spindle microtubule//bacterial-type flagellum//DASH complex//endoplasmic reticulum//extracellular region//membrane KOG2343 Glucose-repressible protein and related proteins Cluster-8309.45445 BP_3 148.43 3.31 2450 91079234 XP_970844.1 3509 0.0e+00 PREDICTED: TFIIH basal transcription factor complex helicase XPD subunit [Tribolium castaneum]>gi|270003570|gb|EFA00018.1| hypothetical protein TcasGA2_TC002825 [Tribolium castaneum] 572310025 XM_006620723.1 529 0 PREDICTED: Apis dorsata TFIIH basal transcription factor complex helicase XPD subunit-like (LOC102676342), mRNA K10844 ERCC2, XPD DNA excision repair protein ERCC-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10844 O08811 2758 1.0e-310 TFIIH basal transcription factor complex helicase XPD subunit OS=Mus musculus GN=Ercc2 PE=2 SV=2 PF06733//PF06777//PF13307//PF00580//PF00176//PF02562//PF04851//PF00270 DEAD_2//Helical and beta-bridge domain//Helicase C-terminal domain//UvrD/REP helicase N-terminal domain//SNF2 family N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0006139//GO:0006289 nucleobase-containing compound metabolic process//nucleotide-excision repair GO:0005524//GO:0016787//GO:0003677//GO:0008026//GO:0004003//GO:0003676//GO:0016818 ATP binding//hydrolase activity//DNA binding//ATP-dependent helicase activity//ATP-dependent DNA helicase activity//nucleic acid binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005657//GO:0005634 replication fork//nucleus KOG1131 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 Cluster-8309.45446 BP_3 895.25 11.41 4073 189242134 XP_968235.2 1493 2.0e-162 PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 1.2e-111 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF05118//PF00515//PF13414//PF04812//PF13176//PF13181//PF15339//PF13174 Aspartyl/Asparaginyl beta-hydroxylase//Tetratricopeptide repeat//TPR repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//Tetratricopeptide repeat//Tetratricopeptide repeat//Acrosome formation-associated factor//Tetratricopeptide repeat GO:0045893//GO:0018193//GO:0006897//GO:0060478//GO:0007342 positive regulation of transcription, DNA-templated//peptidyl-amino acid modification//endocytosis//acrosomal vesicle exocytosis//fusion of sperm to egg plasma membrane GO:0005515 protein binding GO:0005886//GO:0005634 plasma membrane//nucleus KOG3696 Aspartyl beta-hydroxylase Cluster-8309.45447 BP_3 67.72 0.61 5665 270009582 EFA06030.1 3151 0.0e+00 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] 749781041 XM_011146561.1 110 1.83165e-47 PREDICTED: Harpegnathos saltator uncharacterized LOC105186395 (LOC105186395), mRNA K05725 PTK2, FAK focal adhesion kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05725 O35346 1778 1.0e-196 Focal adhesion kinase 1 OS=Rattus norvegicus GN=Ptk2 PE=1 SV=1 PF03623//PF07714//PF00069 Focal adhesion targeting region//Protein tyrosine kinase//Protein kinase domain GO:0007165//GO:0006468//GO:0007172 signal transduction//protein phosphorylation//signal complex assembly GO:0004871//GO:0004672//GO:0004713//GO:0005524 signal transducer activity//protein kinase activity//protein tyrosine kinase activity//ATP binding GO:0005925 focal adhesion KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain Cluster-8309.45448 BP_3 34.38 2.21 1042 270002439 EEZ98886.1 272 1.9e-21 hypothetical protein TcasGA2_TC004501 [Tribolium castaneum] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 135 6.2e-07 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862 DDHD domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.45452 BP_3 661.43 6.09 5529 189239298 XP_971413.2 2145 6.7e-238 PREDICTED: protein lingerer isoform X3 [Tribolium castaneum] 642928928 XM_966320.3 252 2.0647e-126 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X4, mRNA -- -- -- -- Q16VD3 579 1.1e-57 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45453 BP_3 182.59 4.84 2110 91078388 XP_974322.1 1200 9.8e-129 PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|642915363|ref|XP_008190586.1| PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|270003984|gb|EFA00432.1| hypothetical protein TcasGA2_TC003286 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q92051 566 1.3e-56 Carbonic anhydrase OS=Danio rerio GN=cahz PE=1 SV=2 -- -- GO:0006730//GO:0006807 one-carbon metabolic process//nitrogen compound metabolic process GO:0008270//GO:0004089//GO:0046872 zinc ion binding//carbonate dehydratase activity//metal ion binding -- -- -- -- Cluster-8309.45454 BP_3 272.96 3.08 4567 642919794 XP_008192070.1 4448 0.0e+00 PREDICTED: coronin-7 isoform X1 [Tribolium castaneum]>gi|270005922|gb|EFA02370.1| hypothetical protein TcasGA2_TC008045 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1086 1.4e-116 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.45455 BP_3 573.12 4.93 5900 642919794 XP_008192070.1 4571 0.0e+00 PREDICTED: coronin-7 isoform X1 [Tribolium castaneum]>gi|270005922|gb|EFA02370.1| hypothetical protein TcasGA2_TC008045 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1118 3.6e-120 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF00400//PF04053 WD domain, G-beta repeat//Coatomer WD associated region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.45456 BP_3 221.01 3.19 3627 642910776 XP_008193405.1 2342 6.3e-261 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 2.54731e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1170 2.1e-126 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.45457 BP_3 1370.01 21.11 3420 642936769 XP_008198572.1 840 8.8e-87 PREDICTED: general transcription factor IIF subunit 1 isoform X2 [Tribolium castaneum] 820846436 XM_012485722.1 154 3.82276e-72 PREDICTED: Apis florea general transcription factor IIF subunit 1-like (LOC100863803), mRNA K03138 TFIIF1, GTF2F1, TFG1 transcription initiation factor TFIIF subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03138 Q05913 679 1.7e-69 General transcription factor IIF subunit 1 OS=Drosophila melanogaster GN=TfIIFalpha PE=1 SV=3 PF08202//PF05793 Mis12-Mtw1 protein family//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0051301//GO:0032968//GO:0007059//GO:0006367 cell division//positive regulation of transcription elongation from RNA polymerase II promoter//chromosome segregation//transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005634//GO:0000444 nucleus//MIS12/MIND type complex KOG2393 Transcription initiation factor IIF, large subunit (RAP74) Cluster-8309.45458 BP_3 60.35 0.89 3551 642936769 XP_008198572.1 580 1.3e-56 PREDICTED: general transcription factor IIF subunit 1 isoform X2 [Tribolium castaneum] 820846436 XM_012485722.1 115 1.90043e-50 PREDICTED: Apis florea general transcription factor IIF subunit 1-like (LOC100863803), mRNA K03138 TFIIF1, GTF2F1, TFG1 transcription initiation factor TFIIF subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03138 Q05913 461 3.3e-44 General transcription factor IIF subunit 1 OS=Drosophila melanogaster GN=TfIIFalpha PE=1 SV=3 PF05793//PF08202 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Mis12-Mtw1 protein family GO:0051301//GO:0032968//GO:0006367//GO:0007059 cell division//positive regulation of transcription elongation from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//chromosome segregation GO:0003677 DNA binding GO:0005634//GO:0000444 nucleus//MIS12/MIND type complex KOG2393 Transcription initiation factor IIF, large subunit (RAP74) Cluster-8309.45460 BP_3 59.52 0.64 4740 478257975 ENN78113.1 1310 3.8e-141 hypothetical protein YQE_05267, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V0D5 622 9.5e-63 Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1 PF02615 Malate/L-lactate dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.45461 BP_3 1279.68 9.54 6757 546677006 ERL87922.1 2801 0.0e+00 hypothetical protein D910_05310 [Dendroctonus ponderosae] 642917861 XM_008193096.1 494 0 PREDICTED: Tribolium castaneum protein dopey-1 homolog (LOC656419), mRNA K02146 ATPeV0D, ATP6D V-type H+-transporting ATPase subunit d http://www.genome.jp/dbget-bin/www_bget?ko:K02146 Q25531 1736 9.0e-192 V-type proton ATPase subunit d OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2957 Vacuolar H+-ATPase V0 sector, subunit d Cluster-8309.45462 BP_3 8.51 0.33 1519 642934319 XP_008198599.1 370 1.2e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45463 BP_3 249.88 1.89 6656 270006862 EFA03310.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013252 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q96IG2 1483 1.9e-162 F-box/LRR-repeat protein 20 OS=Homo sapiens GN=FBXL20 PE=1 SV=2 PF13855//PF00152//PF13516//PF02126//PF12937//PF00646//PF00560//PF15966 Leucine rich repeat//tRNA synthetases class II (D, K and N)//Leucine Rich repeat//Phosphotriesterase family//F-box-like//F-box domain//Leucine Rich Repeat//F-box GO:0009056//GO:0006418 catabolic process//tRNA aminoacylation for protein translation GO:0005515//GO:0004812//GO:0000166//GO:0008270//GO:0005524 protein binding//aminoacyl-tRNA ligase activity//nucleotide binding//zinc ion binding//ATP binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.45465 BP_3 19.54 0.55 2011 642912047 XP_008199070.1 141 5.8e-06 PREDICTED: nuclear factor 1 C-type isoform X1 [Tribolium castaneum]>gi|270014496|gb|EFA10944.1| hypothetical protein TcasGA2_TC001775 [Tribolium castaneum] 58037658 AC152508.3 177 3.65797e-85 Tribolium castaneum BAC T.cast_C29K22 (Clemson University Genomics Institute Tribolium castaneum BAC Library (Red Flour Beetle)) complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45466 BP_3 659.32 11.36 3089 91078902 XP_973455.1 1013 6.9e-107 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q3ZBT5 504 3.0e-49 Syntaxin-7 OS=Bos taurus GN=STX7 PE=2 SV=1 PF04632//PF02561//PF05531//PF00957//PF08597//PF00804//PF00015//PF05739 Fusaric acid resistance protein family//Flagellar protein FliS//Nucleopolyhedrovirus P10 protein//Synaptobrevin//Translation initiation factor eIF3 subunit//Syntaxin//Methyl-accepting chemotaxis protein (MCP) signalling domain//SNARE domain GO:0007165//GO:0006446//GO:0016192//GO:0006810 signal transduction//regulation of translational initiation//vesicle-mediated transport//transport GO:0004871//GO:0003743//GO:0005515 signal transducer activity//translation initiation factor activity//protein binding GO:0016020//GO:0005840//GO:0009288//GO:0005737//GO:0005852//GO:0005886//GO:0019028//GO:0016021 membrane//ribosome//bacterial-type flagellum//cytoplasm//eukaryotic translation initiation factor 3 complex//plasma membrane//viral capsid//integral component of membrane KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.45468 BP_3 610.09 9.15 3504 91081981 XP_968444.1 1956 3.5e-216 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921927|ref|XP_008192949.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921929|ref|XP_008192950.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270007370|gb|EFA03818.1| hypothetical protein TcasGA2_TC013933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 822 4.5e-86 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083//PF02568 Major Facilitator Superfamily//Sugar (and other) transporter//Thiamine biosynthesis protein (ThiI) GO:0055085//GO:0008033 transmembrane transport//tRNA processing GO:0022857//GO:0004810 transmembrane transporter activity//tRNA adenylyltransferase activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.45469 BP_3 95.60 1.37 3651 91081981 XP_968444.1 1956 3.7e-216 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921927|ref|XP_008192949.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921929|ref|XP_008192950.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270007370|gb|EFA03818.1| hypothetical protein TcasGA2_TC013933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 822 4.7e-86 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF02568//PF07690//PF00083 Thiamine biosynthesis protein (ThiI)//Major Facilitator Superfamily//Sugar (and other) transporter GO:0008033//GO:0055085 tRNA processing//transmembrane transport GO:0022857//GO:0004810 transmembrane transporter activity//tRNA adenylyltransferase activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.45470 BP_3 38.37 0.51 3953 91081981 XP_968444.1 1097 1.6e-116 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921927|ref|XP_008192949.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921929|ref|XP_008192950.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270007370|gb|EFA03818.1| hypothetical protein TcasGA2_TC013933 [Tribolium castaneum] -- -- -- -- -- K08202 SLC22A4_5, OCTN MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K08202 Q9VMX0 787 5.8e-82 39S ribosomal protein L28, mitochondrial OS=Drosophila melanogaster GN=mRpL28 PE=2 SV=1 PF00083//PF07690//PF02568 Sugar (and other) transporter//Major Facilitator Superfamily//Thiamine biosynthesis protein (ThiI) GO:0008033//GO:0055085 tRNA processing//transmembrane transport GO:0004810//GO:0022857 tRNA adenylyltransferase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.45472 BP_3 100.17 4.58 1346 642938577 XP_008199848.1 280 3.0e-22 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938579|ref|XP_008199849.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938581|ref|XP_008199850.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938583|ref|XP_008199851.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938585|ref|XP_008199852.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|270015602|gb|EFA12050.1| hypothetical protein TcasGA2_TC001467 [Tribolium castaneum] 642938584 XM_008201630.1 147 1.15336e-68 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0003824//GO:0005388 catalytic activity//calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum -- -- Cluster-8309.45474 BP_3 164.63 7.97 1287 642912973 XP_008201334.1 1180 1.2e-126 PREDICTED: elongator complex protein 4 [Tribolium castaneum] -- -- -- -- -- K11375 ELP4 elongator complex protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11375 Q5XG58 511 1.9e-50 Elongator complex protein 4 OS=Xenopus laevis GN=elp4 PE=2 SV=1 PF05625 PAXNEB protein -- -- -- -- GO:0033588 Elongator holoenzyme complex KOG3949 RNA polymerase II elongator complex, subunit ELP4 Cluster-8309.45476 BP_3 1235.27 13.45 4719 642930284 XP_008196328.1 1023 7.3e-108 PREDICTED: fanconi-associated nuclease 1 homolog isoform X1 [Tribolium castaneum]>gi|270010701|gb|EFA07149.1| hypothetical protein TcasGA2_TC010140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LWH4 450 8.3e-43 Fanconi-associated nuclease 1 OS=Danio rerio GN=fan1 PE=2 SV=2 PF08774 VRR-NUC domain -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2143 Uncharacterized conserved protein Cluster-8309.45477 BP_3 23.00 5.67 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45480 BP_3 295.50 1.92 7704 817058126 XP_012250513.1 1919 1.5e-211 PREDICTED: beta-1,4-mannosyltransferase egh isoform X1 [Athalia rosae]>gi|817058128|ref|XP_012250514.1| PREDICTED: beta-1,4-mannosyltransferase egh isoform X1 [Athalia rosae] 642920158 XM_970403.3 374 0 PREDICTED: Tribolium castaneum beta-1,4-mannosyltransferase egh (LOC664396), mRNA K02359 EGH egghead protein (zeste-white 4 protein) http://www.genome.jp/dbget-bin/www_bget?ko:K02359 O01346 1850 6.2e-205 Beta-1,4-mannosyltransferase egh OS=Drosophila melanogaster GN=egh PE=2 SV=1 PF13506//PF00651 Glycosyl transferase family 21//BTB/POZ domain -- -- GO:0005515//GO:0016757 protein binding//transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.45484 BP_3 338.00 9.45 2015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05313 Poxvirus P21 membrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45486 BP_3 30.26 0.47 3382 642913496 XP_008201037.1 981 3.9e-103 PREDICTED: uncharacterized protein LOC100142275 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45487 BP_3 976.20 17.13 3038 189234485 XP_001811926.1 1069 2.2e-113 PREDICTED: uncharacterized protein LOC100142275 isoform X2 [Tribolium castaneum]>gi|270001729|gb|EEZ98176.1| hypothetical protein TcasGA2_TC000605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45489 BP_3 333.61 13.52 1481 642912091 XP_008200799.1 1091 3.0e-116 PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912093|ref|XP_008200800.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912095|ref|XP_008200802.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45490 BP_3 10.00 1.76 565 91083643 XP_966464.1 235 2.1e-17 PREDICTED: protein Spindly [Tribolium castaneum]>gi|270007854|gb|EFA04302.1| hypothetical protein TcasGA2_TC014594 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3KR99 169 3.8e-11 Protein Spindly OS=Rattus norvegicus GN=Spdl1 PE=2 SV=1 PF04111//PF06156//PF07851//PF13851//PF12179//PF10186//PF07926//PF08702//PF00038 Autophagy protein Apg6//Protein of unknown function (DUF972)//TMPIT-like protein//Growth-arrest specific micro-tubule binding//I-kappa-kinase-beta NEMO binding domain//Vacuolar sorting 38 and autophagy-related subunit 14//TPR/MLP1/MLP2-like protein//Fibrinogen alpha/beta chain family//Intermediate filament protein GO:0006260//GO:0006606//GO:0010508//GO:0007165//GO:0009069//GO:0006914//GO:0051258//GO:0030168//GO:0016310//GO:0048870 DNA replication//protein import into nucleus//positive regulation of autophagy//signal transduction//serine family amino acid metabolic process//autophagy//protein polymerization//platelet activation//phosphorylation//cell motility GO:0005102//GO:0005198//GO:0008384//GO:0030674 receptor binding//structural molecule activity//IkappaB kinase activity//protein binding, bridging GO:0005577//GO:0031514//GO:0016021//GO:0005882//GO:0008385 fibrinogen complex//motile cilium//integral component of membrane//intermediate filament//IkappaB kinase complex -- -- Cluster-8309.45495 BP_3 38.56 2.10 1175 194754345 XP_001959456.1 143 2.0e-06 GF12046 [Drosophila ananassae]>gi|190620754|gb|EDV36278.1| GF12046 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04487//PF01155 CITED//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006355 cellular protein modification process//regulation of transcription, DNA-templated GO:0016151 nickel cation binding GO:0005634 nucleus -- -- Cluster-8309.45496 BP_3 289.78 1.12 12774 642926088 XP_008194761.1 1377 1.8e-148 PREDICTED: uncharacterized protein LOC103313398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 153 6.2e-08 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF02990//PF15220//PF01222//PF09606//PF01214 Endomembrane protein 70//Hypoxia-inducible lipid droplet-associated//Ergosterol biosynthesis ERG4/ERG24 family//ARC105 or Med15 subunit of Mediator complex non-fungal//Casein kinase II regulatory subunit GO:0045859//GO:0010884//GO:0001819//GO:0008284//GO:0006357 regulation of protein kinase activity//positive regulation of lipid storage//positive regulation of cytokine production//positive regulation of cell proliferation//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0019887 RNA polymerase II transcription cofactor activity//protein kinase regulator activity GO:0016021//GO:0016592//GO:0005956//GO:0016020 integral component of membrane//mediator complex//protein kinase CK2 complex//membrane -- -- Cluster-8309.45498 BP_3 1.00 2.95 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45499 BP_3 17.87 0.50 2024 546683208 ERL93048.1 660 3.9e-66 hypothetical protein D910_10350 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45500 BP_3 229.69 3.38 3564 189241728 XP_966529.2 1790 6.3e-197 PREDICTED: polycomb protein Scm [Tribolium castaneum] 817209209 XM_012425227.1 101 1.15615e-42 PREDICTED: Orussus abietinus polycomb protein Scm-like (LOC105699853), transcript variant X3, mRNA K11461 SCMH1 polycomb protein SCMH1 http://www.genome.jp/dbget-bin/www_bget?ko:K11461 Q9VHA0 1356 5.5e-148 Polycomb protein Scm OS=Drosophila melanogaster GN=Scm PE=1 SV=2 PF05495//PF02820//PF02069//PF03145//PF06467 CHY zinc finger//mbt repeat//Prokaryotic metallothionein//Seven in absentia protein family//MYM-type Zinc finger with FCS sequence motif GO:0006511//GO:0006355//GO:0007275 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.45501 BP_3 63.56 0.66 4932 642925869 XP_008190626.1 2498 7.0e-279 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 Q9P2N4 1274 2.5e-138 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF01421//PF05986//PF00413//PF01562 Reprolysin (M12B) family zinc metalloprotease//ADAM-TS Spacer 1//Matrixin//Reprolysin family propeptide GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.45505 BP_3 29.67 0.82 2032 642916102 XP_971729.2 1730 3.3e-190 PREDICTED: DDB1- and CUL4-associated factor 11 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q5R7H5 1196 1.1e-129 DDB1- and CUL4-associated factor 11 OS=Pongo abelii GN=DCAF11 PE=2 SV=2 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0266 WD40 repeat-containing protein Cluster-8309.45506 BP_3 5354.33 27.54 9663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45509 BP_3 579.35 4.00 7266 642915546 XP_008190660.1 7945 0.0e+00 PREDICTED: serine/threonine-protein kinase SMG1 [Tribolium castaneum] -- -- -- -- -- K08873 SMG1 PI-3-kinase-related kinase SMG-1 http://www.genome.jp/dbget-bin/www_bget?ko:K08873 Q8BKX6 1869 3.7e-207 Serine/threonine-protein kinase SMG1 OS=Mus musculus GN=Smg1 PE=1 SV=3 PF15785//PF00454//PF08771 Serine/threonine-protein kinase smg-1//Phosphatidylinositol 3- and 4-kinase//Rapamycin binding domain GO:0009069//GO:0000184//GO:0016310 serine family amino acid metabolic process//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//phosphorylation GO:0008144//GO:0004674//GO:0016773 drug binding//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG0891 DNA-dependent protein kinase Cluster-8309.45512 BP_3 841.00 9.02 4786 642915546 XP_008190660.1 3375 0.0e+00 PREDICTED: serine/threonine-protein kinase SMG1 [Tribolium castaneum] 642915545 XM_008192438.1 117 1.9853e-51 PREDICTED: Tribolium castaneum serine/threonine-protein kinase SMG1 (LOC658025), mRNA K08873 SMG1 PI-3-kinase-related kinase SMG-1 http://www.genome.jp/dbget-bin/www_bget?ko:K08873 Q8BKX6 999 1.8e-106 Serine/threonine-protein kinase SMG1 OS=Mus musculus GN=Smg1 PE=1 SV=3 PF05773//PF02260 RWD domain//FATC domain -- -- GO:0005515 protein binding -- -- KOG0891 DNA-dependent protein kinase Cluster-8309.45513 BP_3 344.65 2.40 7214 642915546 XP_008190660.1 7945 0.0e+00 PREDICTED: serine/threonine-protein kinase SMG1 [Tribolium castaneum] -- -- -- -- -- K08873 SMG1 PI-3-kinase-related kinase SMG-1 http://www.genome.jp/dbget-bin/www_bget?ko:K08873 Q8BKX6 1869 3.7e-207 Serine/threonine-protein kinase SMG1 OS=Mus musculus GN=Smg1 PE=1 SV=3 PF08771//PF15785//PF00454 Rapamycin binding domain//Serine/threonine-protein kinase smg-1//Phosphatidylinositol 3- and 4-kinase GO:0009069//GO:0016310//GO:0000184 serine family amino acid metabolic process//phosphorylation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0016773//GO:0008144//GO:0004674 phosphotransferase activity, alcohol group as acceptor//drug binding//protein serine/threonine kinase activity -- -- KOG0891 DNA-dependent protein kinase Cluster-8309.45514 BP_3 113.66 0.73 7804 91087059 XP_974768.1 2503 2.9e-279 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum] 557328628 XM_006037179.1 83 2.58075e-32 PREDICTED: Alligator sinensis SMAD family member 2 (SMAD2), transcript variant X2, mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 1461 8.1e-160 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF03165//PF01401 MH1 domain//Angiotensin-converting enzyme GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020//GO:0005622 membrane//intracellular -- -- Cluster-8309.45516 BP_3 2085.44 17.05 6187 91087059 XP_974768.1 2503 2.3e-279 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum] 705688348 XM_010123009.1 125 9.18128e-56 PREDICTED: Chlamydotis macqueenii SMAD family member 2 (SMAD2), transcript variant X2, mRNA K04500 SMAD2_3 mothers against decapentaplegic homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K04500 P84022 1609 4.4e-177 Mothers against decapentaplegic homolog 3 OS=Homo sapiens GN=SMAD3 PE=1 SV=1 PF01401//PF10401//PF03166//PF03165 Angiotensin-converting enzyme//Interferon-regulatory factor 3//MH2 domain//MH1 domain GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0008241//GO:0008237//GO:0003700 peptidyl-dipeptidase activity//metallopeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622//GO:0016020 transcription factor complex//intracellular//membrane -- -- Cluster-8309.45517 BP_3 59.00 19.50 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45521 BP_3 2.00 1.44 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45522 BP_3 1.00 39.62 211 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45524 BP_3 2000.32 35.90 2977 91094931 XP_970563.1 2741 2.8e-307 PREDICTED: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase [Tribolium castaneum]>gi|270016688|gb|EFA13134.1| hypothetical protein TcasGA2_TC010318 [Tribolium castaneum] 572264375 XM_006610309.1 75 2.73716e-28 PREDICTED: Apis dorsata bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2-like (LOC102670740), transcript variant X2, mRNA K13811 PAPSS 3'-phosphoadenosine 5'-phosphosulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13811 Q27128 2136 1.6e-238 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase OS=Urechis caupo PE=2 SV=1 PF01583//PF01747 Adenylylsulphate kinase//ATP-sulfurylase GO:0006790//GO:0000103//GO:0006144 sulfur compound metabolic process//sulfate assimilation//purine nucleobase metabolic process GO:0004781//GO:0005524//GO:0004020 sulfate adenylyltransferase (ATP) activity//ATP binding//adenylylsulfate kinase activity -- -- KOG4238 Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase Cluster-8309.45527 BP_3 109.39 1.19 4707 642910357 XP_008200291.1 5527 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase Genghis Khan [Tribolium castaneum] 642910356 XM_008202069.1 1028 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 1944 4.8e-216 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF07714//PF00433//PF00069//PF00130//PF08826//PF01291 Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//DMPK coiled coil domain like//LIF / OSM family GO:0006955//GO:0035556//GO:0007165//GO:0009069//GO:0006468//GO:0016310 immune response//intracellular signal transduction//signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005125//GO:0004674//GO:0004672//GO:0005524 cytokine activity//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0005576 extracellular region KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.45528 BP_3 5.00 0.96 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00236 Glycoprotein hormone GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.45529 BP_3 1012.08 4.72 10616 270014310 EFA10758.1 3865 0.0e+00 starry night [Tribolium castaneum] 332376259 BT128312.1 203 6.89136e-99 Dendroctonus ponderosae clone DPO105_N17 unknown mRNA K04600 CELSR1 cadherin EGF LAG seven-pass G-type receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04600 Q9V5N8 1132 1.5e-121 Protocadherin-like wing polarity protein stan OS=Drosophila melanogaster GN=stan PE=1 SV=4 PF04670//PF00071//PF02793//PF01825//PF00837//PF03193//PF07732//PF03348//PF00025//PF02421//PF00002//PF01926//PF08477 Gtr1/RagA G protein conserved region//Ras family//Hormone receptor domain//GPCR proteolysis site, GPS, motif//Iodothyronine deiodinase//Protein of unknown function, DUF258//Multicopper oxidase//Serine incorporator (Serinc)//ADP-ribosylation factor family//Ferrous iron transport protein B//7 transmembrane receptor (Secretin family)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0007264//GO:0055114//GO:0015684 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//oxidation-reduction process//ferrous iron transport GO:0015093//GO:0005507//GO:0004930//GO:0003924//GO:0004800//GO:0005525 ferrous iron transmembrane transporter activity//copper ion binding//G-protein coupled receptor activity//GTPase activity//thyroxine 5'-deiodinase activity//GTP binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0395 Ras-related GTPase Cluster-8309.45530 BP_3 13.18 0.88 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83653 208 2.1e-15 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.45531 BP_3 47.49 0.58 4241 642918008 XP_008198978.1 844 3.7e-87 PREDICTED: E3 ubiquitin-protein ligase rnf146 [Tribolium castaneum] -- -- -- -- -- K15700 RNF146 E3 ubiquitin-protein ligase RNF146 http://www.genome.jp/dbget-bin/www_bget?ko:K15700 Q5XIK5 576 1.8e-57 E3 ubiquitin-protein ligase RNF146 OS=Rattus norvegicus GN=Rnf146 PE=2 SV=1 PF16685//PF13639//PF00097//PF14634//PF12678 zinc RING finger of MSL2//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-H2 zinc finger -- -- GO:0008270//GO:0046872//GO:0005515//GO:0061630 zinc ion binding//metal ion binding//protein binding//ubiquitin protein ligase activity -- -- KOG0824 Predicted E3 ubiquitin ligase Cluster-8309.45533 BP_3 394.97 17.40 1386 642931051 XP_008196192.1 746 2.8e-76 PREDICTED: myeloid leukemia factor isoform X4 [Tribolium castaneum]>gi|270012061|gb|EFA08509.1| hypothetical protein TcasGA2_TC006162 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NKV0 358 1.1e-32 Myeloid leukemia factor OS=Drosophila melanogaster GN=Mlf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45534 BP_3 150.62 3.10 2636 827551061 XP_012547435.1 489 3.4e-46 PREDICTED: cAMP-dependent protein kinase catalytic subunit alpha-like [Bombyx mori] -- -- -- -- -- K04345 PKA protein kinase A http://www.genome.jp/dbget-bin/www_bget?ko:K04345 P17612 484 5.3e-47 cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens GN=PRKACA PE=1 SV=2 PF00069//PF07714//PF16035 Protein kinase domain//Protein tyrosine kinase//Chalcone isomerase like GO:0006468 protein phosphorylation GO:0016872//GO:0004672//GO:0005524 intramolecular lyase activity//protein kinase activity//ATP binding -- -- KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA) Cluster-8309.45535 BP_3 374.52 1.59 11627 642936312 XP_008198391.1 8183 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 1.00468e-77 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3630 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF03822//PF14604//PF00018//PF07651//PF01608 NAF domain//Variant SH3 domain//SH3 domain//ANTH domain//I/LWEQ domain GO:0007165 signal transduction GO:0003779//GO:0005515//GO:0005543 actin binding//protein binding//phospholipid binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.45537 BP_3 72.98 4.29 1111 546674232 ERL85660.1 317 1.3e-26 hypothetical protein D910_03077 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45539 BP_3 1681.39 15.82 5416 642925019 XP_008194138.1 3889 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X2 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.61604e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.6e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.4554 BP_3 59.00 0.88 3521 752868491 XP_011251320.1 533 3.6e-51 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Camponotus floridanus]>gi|752875846|ref|XP_011255293.1| PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Camponotus floridanus] 168488035 EU365789.1 222 6.22526e-110 Drosophila yakuba strain CY27 tan gene, 5' upstream region -- -- -- -- Q9NBX4 156 7.7e-09 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 PF01975 Survival protein SurE -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.45540 BP_3 4.00 0.35 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45541 BP_3 411.14 14.32 1676 91092034 XP_969657.1 1306 4.0e-141 PREDICTED: proton-coupled amino acid transporter 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 499 6.1e-49 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.45542 BP_3 150.61 1.15 6585 642917952 XP_008198956.1 1185 1.7e-126 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 499 2.4e-48 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.45543 BP_3 264.00 4.12 3377 642933143 XP_008197274.1 3049 0.0e+00 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] 642933142 XM_008199052.1 70 1.8714e-25 PREDICTED: Tribolium castaneum UPF0378 protein KIAA0100 (LOC662561), mRNA -- -- -- -- Q5SYL3 445 2.3e-42 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1910 Uncharacterized conserved protein Cluster-8309.45544 BP_3 518.96 7.22 3754 642934158 XP_968636.2 1148 1.9e-122 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 680 1.4e-69 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01805//PF01151 Surp module//GNS1/SUR4 family GO:0006396 RNA processing GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.45545 BP_3 75.04 0.86 4492 91086115 XP_968072.1 1323 1.1e-142 PREDICTED: sister chromatid cohesion protein DCC1 [Tribolium castaneum] -- -- -- -- -- K11271 DSCC1, DCC1 sister chromatid cohesion protein DCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K11271 Q6GMB0 633 4.8e-64 Sister chromatid cohesion protein DCC1 OS=Xenopus laevis GN=dscc1 PE=2 SV=1 PF00018//PF14604//PF04088//PF04421 SH3 domain//Variant SH3 domain//Peroxin 13, N-terminal region//Mss4 protein GO:0007264//GO:0043087//GO:0016560 small GTPase mediated signal transduction//regulation of GTPase activity//protein import into peroxisome matrix, docking GO:0005515//GO:0005085 protein binding//guanyl-nucleotide exchange factor activity GO:0005777//GO:0016021 peroxisome//integral component of membrane KOG3875 Peroxisomal biogenesis protein peroxin Cluster-8309.45548 BP_3 291.19 2.87 5181 91091282 XP_966431.1 1870 4.9e-206 PREDICTED: rab5 GDP/GTP exchange factor isoform X1 [Tribolium castaneum]>gi|270013085|gb|EFA09533.1| hypothetical protein TcasGA2_TC011637 [Tribolium castaneum] 642936530 XM_961338.3 239 3.25906e-119 PREDICTED: Tribolium castaneum rab5 GDP/GTP exchange factor (LOC658256), transcript variant X1, mRNA -- -- -- -- O18973 696 2.7e-71 Rab5 GDP/GTP exchange factor OS=Bos taurus GN=RABGEF1 PE=1 SV=1 PF01754 A20-like zinc finger -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.45549 BP_3 13.00 0.60 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45552 BP_3 564.80 4.80 5965 642937896 XP_008200347.1 2573 1.7e-287 PREDICTED: protein vav isoform X1 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 1473 2.5e-161 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF00130//PF00307//PF00018//PF14604//PF00621 Phorbol esters/diacylglycerol binding domain (C1 domain)//Calponin homology (CH) domain//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0035556//GO:0043087//GO:0035023 intracellular signal transduction//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.45554 BP_3 805.35 9.66 4310 478251097 ENN71573.1 1390 1.9e-150 hypothetical protein YQE_11673, partial [Dendroctonus ponderosae] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 209 6.7e-15 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402//PF00036 Man1-Src1p-C-terminal domain//EF hand -- -- GO:0005509 calcium ion binding GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.45555 BP_3 487.76 35.08 962 270002027 EEZ98474.1 452 2.4e-42 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWD0 135 5.7e-07 Gametocyte-specific factor 1-like OS=Mus musculus GN=Gtsf1l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4376 Uncharacterized conserved protein Cluster-8309.45556 BP_3 515.00 19.42 1570 780104265 XP_011675652.1 245 4.0e-18 PREDICTED: zinc finger protein 883 isoform X1 [Strongylocentrotus purpuratus] -- -- -- -- -- K09207 KLF6_7 krueppel-like factor 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K09207 Q5VIY5 232 5.3e-18 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF00797//PF04931//PF00096//PF13465 N-acetyltransferase//DNA polymerase phi//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006351//GO:0008152//GO:0042967//GO:0006260 transcription, DNA-templated//metabolic process//acyl-carrier-protein biosynthetic process//DNA replication GO:0003677//GO:0016407//GO:0003887//GO:0046872 DNA binding//acetyltransferase activity//DNA-directed DNA polymerase activity//metal ion binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.45558 BP_3 47.52 0.47 5132 91089275 XP_970398.1 2665 3.2e-298 PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase 9 isoform X1 [Tribolium castaneum] 642933027 XM_965305.2 493 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 2186 4.5e-244 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.45560 BP_3 25.16 1.33 1201 270014029 EFA10477.1 331 3.2e-28 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 3.93196e-23 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- O94842 173 2.8e-11 TOX high mobility group box family member 4 OS=Homo sapiens GN=TOX4 PE=1 SV=1 PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.45562 BP_3 686.12 23.72 1686 642912158 XP_008200830.1 1263 3.9e-136 PREDICTED: tRNA pseudouridine synthase A, mitochondrial [Tribolium castaneum] -- -- -- -- -- K06173 truA, PUS1 tRNA pseudouridine38-40 synthase http://www.genome.jp/dbget-bin/www_bget?ko:K06173 Q9WU56 870 5.9e-92 tRNA pseudouridine synthase A, mitochondrial OS=Mus musculus GN=Pus1 PE=1 SV=2 PF01416 tRNA pseudouridine synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG2553 Pseudouridylate synthase Cluster-8309.45564 BP_3 682.14 9.55 3733 642913781 XP_008201158.1 1088 1.7e-115 PREDICTED: programmed cell death protein 2-like [Tribolium castaneum] -- -- -- -- -- K14801 TSR4 pre-rRNA-processing protein TSR4 http://www.genome.jp/dbget-bin/www_bget?ko:K14801 Q8C5N5 232 1.3e-17 Programmed cell death protein 2-like OS=Mus musculus GN=Pdcd2l PE=2 SV=1 PF04194//PF01150 Programmed cell death protein 2, C-terminal putative domain//GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity GO:0005737 cytoplasm KOG2061 Uncharacterized MYND Zn-finger protein Cluster-8309.45566 BP_3 37.13 0.68 2916 642934335 XP_969733.2 2631 1.6e-294 PREDICTED: tripartite motif-containing protein 2 isoform X5 [Tribolium castaneum] 817086197 XM_012410395.1 92 9.50493e-38 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 O75382 343 1.3e-30 Tripartite motif-containing protein 3 OS=Homo sapiens GN=TRIM3 PE=1 SV=2 PF05149//PF01637//PF02601//PF01580//PF13639//PF14634//PF00643//PF00097//PF05929//PF09815//PF05524//PF01436 Paraflagellar rod protein//Archaeal ATPase//Exonuclease VII, large subunit//FtsK/SpoIIIE family//Ring finger domain//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger)//Phage capsid scaffolding protein (GPO) serine peptidase//XK-related protein//PEP-utilising enzyme, N-terminal//NHL repeat GO:0019069//GO:0006308//GO:0009401 viral capsid assembly//DNA catabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0008855//GO:0005515//GO:0005524//GO:0005516//GO:0003677//GO:0046872//GO:0000166//GO:0008270 exodeoxyribonuclease VII activity//protein binding//ATP binding//calmodulin binding//DNA binding//metal ion binding//nucleotide binding//zinc ion binding GO:0016021//GO:0031514//GO:0009318//GO:0005622 integral component of membrane//motile cilium//exodeoxyribonuclease VII complex//intracellular -- -- Cluster-8309.45571 BP_3 54.84 0.58 4858 642935897 XP_008198219.1 936 9.2e-98 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X2 [Tribolium castaneum] 688627348 LL261331.1 74 1.61409e-27 Echinostoma caproni genome assembly E_caproni_Egypt ,scaffold ECPE_scaffold0027233 -- -- -- -- Q8NA58 326 2.0e-28 Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 OS=Homo sapiens GN=PNLDC1 PE=2 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.45573 BP_3 437.37 6.87 3362 642928048 XP_008200135.1 1024 4.0e-108 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 3.2e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF05104//PF04508//PF09392 Ribosome receptor lysine/proline rich region//Viral A-type inclusion protein repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0009405//GO:0016032//GO:0015031 pathogenesis//viral process//protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45574 BP_3 1459.43 23.27 3314 642928044 XP_008200132.1 982 2.9e-103 PREDICTED: ribosome-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2E9 264 2.2e-21 Ribosome-binding protein 1 OS=Homo sapiens GN=RRBP1 PE=1 SV=4 PF09392//PF04508//PF05104 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Viral A-type inclusion protein repeat//Ribosome receptor lysine/proline rich region GO:0016032//GO:0009405//GO:0015031 viral process//pathogenesis//protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45575 BP_3 1919.84 31.69 3212 642928048 XP_008200135.1 946 4.2e-99 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 3.0e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF05104//PF04508//PF09392 Ribosome receptor lysine/proline rich region//Viral A-type inclusion protein repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0015031//GO:0016032//GO:0009405 protein transport//viral process//pathogenesis -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45577 BP_3 10.25 0.37 1619 642928048 XP_008200135.1 274 1.8e-21 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2E9 128 6.2e-06 Ribosome-binding protein 1 OS=Homo sapiens GN=RRBP1 PE=1 SV=4 PF00473 Corticotropin-releasing factor family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.45578 BP_3 37.44 0.94 2204 642928046 XP_008200133.1 748 2.6e-76 PREDICTED: ribosome-binding protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1D823 186 1.6e-12 Adventurous-gliding motility protein Z OS=Myxococcus xanthus (strain DK 1622) GN=aglZ PE=1 SV=1 PF05104 Ribosome receptor lysine/proline rich region GO:0015031 protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45580 BP_3 2.00 0.44 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45582 BP_3 481.76 12.02 2224 642934675 XP_008197763.1 2437 3.7e-272 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 556762122 XM_005976302.1 125 3.26843e-56 PREDICTED: Pantholops hodgsonii adenylate cyclase 1 (brain) (ADCY1), mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1565 2.0e-172 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.45585 BP_3 10.36 0.43 1458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45586 BP_3 18.56 0.64 1694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45587 BP_3 319.30 5.43 3124 642918017 XP_008198981.1 462 5.4e-43 PREDICTED: protein LSM14 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K18749 LSM14, RAP55, SCD6 protein LSM14 http://www.genome.jp/dbget-bin/www_bget?ko:K18749 Q566L7 195 2.0e-13 Protein LSM14 homolog B OS=Xenopus tropicalis GN=lsm14b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1073 Uncharacterized mRNA-associated protein RAP55 Cluster-8309.4559 BP_3 23.30 0.37 3300 270012188 EFA08636.1 2248 4.6e-250 hypothetical protein TcasGA2_TC006299 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44997 577 1.1e-57 Death-associated protein kinase dapk-1 OS=Caenorhabditis elegans GN=dapk-1 PE=2 SV=2 PF13606//PF00023//PF08477//PF14144 Ankyrin repeat//Ankyrin repeat//Ras of Complex, Roc, domain of DAPkinase//Seed dormancy control GO:0006351//GO:0007264 transcription, DNA-templated//small GTPase mediated signal transduction GO:0043565//GO:0005525//GO:0005515 sequence-specific DNA binding//GTP binding//protein binding -- -- -- -- Cluster-8309.45590 BP_3 19.34 0.71 1603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45592 BP_3 177.00 3.25 2915 384255136 AFH75400.1 3825 0.0e+00 elongation factor 2 [Eriocheir sinensis] 393395827 JQ824131.1 2380 0 Scylla paramamosain elongation factor 2 mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3203 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF03144//PF06881 Elongation factor G, domain IV//Elongation factor Tu domain 2//RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated GO:0005525 GTP binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0469 Elongation factor 2 Cluster-8309.45593 BP_3 2550.85 60.65 2319 189234402 XP_974971.2 3224 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 1858 2.2e-206 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF01414//PF00008 Delta serrate ligand//EGF-like domain GO:0007154 cell communication GO:0005515 protein binding GO:0016020 membrane KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.45594 BP_3 19.89 0.51 2161 189234402 XP_974971.2 3224 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 1858 2.1e-206 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF00008//PF01414 EGF-like domain//Delta serrate ligand GO:0007154 cell communication GO:0005515 protein binding GO:0016020 membrane KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.45595 BP_3 5.00 0.90 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45596 BP_3 37.79 0.40 4894 662215753 XP_008481775.1 1611 5.0e-176 PREDICTED: uncharacterized protein LOC103518486 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P04323 865 6.5e-91 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03839//PF13683//PF00665 Translocation protein Sec62//Integrase core domain//Integrase core domain GO:0015074//GO:0015031 DNA integration//protein transport GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.45597 BP_3 359.20 7.88 2488 642918750 XP_008191568.1 1074 4.7e-114 PREDICTED: palmitoyltransferase ZDHHC7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91WU6 360 1.2e-32 Palmitoyltransferase ZDHHC7 OS=Mus musculus GN=Zdhhc7 PE=1 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.45599 BP_3 412.00 12.57 1872 91088645 XP_974426.1 423 1.1e-38 PREDICTED: calcium-binding and coiled-coil domain-containing protein 2 [Tribolium castaneum]>gi|270011685|gb|EFA08133.1| hypothetical protein TcasGA2_TC005737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R914 211 1.7e-15 Calcium-binding and coiled-coil domain-containing protein 2 OS=Macaca fascicularis GN=CALCOCO2 PE=2 SV=1 PF02050//PF00038//PF07544//PF06156//PF07851//PF04111//PF10174//PF13851//PF10186//PF05440 Flagellar FliJ protein//Intermediate filament protein//RNA polymerase II transcription mediator complex subunit 9//Protein of unknown function (DUF972)//TMPIT-like protein//Autophagy protein Apg6//RIM-binding protein of the cytomatrix active zone//Growth-arrest specific micro-tubule binding//Vacuolar sorting 38 and autophagy-related subunit 14//Tetrahydromethanopterin S-methyltransferase subunit B GO:0048870//GO:0071973//GO:0006935//GO:0015948//GO:0010508//GO:0006260//GO:0006357//GO:0046656//GO:0006914 cell motility//bacterial-type flagellum-dependent cell motility//chemotaxis//methanogenesis//positive regulation of autophagy//DNA replication//regulation of transcription from RNA polymerase II promoter//folic acid biosynthetic process//autophagy GO:0003774//GO:0001104//GO:0005198//GO:0030269 motor activity//RNA polymerase II transcription cofactor activity//structural molecule activity//tetrahydromethanopterin S-methyltransferase activity GO:0016020//GO:0016592//GO:0048786//GO:0009288//GO:0005882//GO:0031514//GO:0016021 membrane//mediator complex//presynaptic active zone//bacterial-type flagellum//intermediate filament//motile cilium//integral component of membrane -- -- Cluster-8309.45600 BP_3 121.84 0.93 6621 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.45601 BP_3 187.11 1.49 6351 642923135 XP_008193624.1 2730 1.1e-305 PREDICTED: nuclear receptor coactivator 2 isoform X3 [Tribolium castaneum] 642923146 XM_008195408.1 411 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.2e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.45602 BP_3 72.71 2.16 1914 642937984 XP_008199157.1 229 3.5e-16 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45603 BP_3 393.68 26.90 997 189234473 XP_001808764.1 1192 3.9e-128 PREDICTED: double-strand-break repair protein rad21 homolog isoform X1 [Tribolium castaneum]>gi|270002814|gb|EEZ99261.1| rad21 [Tribolium castaneum] 662206050 XM_008478247.1 93 8.84216e-39 PREDICTED: Diaphorina citri double-strand-break repair protein rad21 homolog (LOC103513421), mRNA K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 725 2.3e-75 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF06766//PF04825 Fungal hydrophobin//N terminus of Rad21 / Rec8 like protein -- -- GO:0005515 protein binding GO:0005576//GO:0000228 extracellular region//nuclear chromosome KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.45604 BP_3 13.42 0.31 2345 642912121 XP_008200815.1 1300 2.7e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6QHF9 414 6.2e-39 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF00070//PF07664//PF00899//PF01134//PF01266//PF01593//PF12831//PF07992//PF01494 Pyridine nucleotide-disulphide oxidoreductase//Ferrous iron transport protein B C terminus//ThiF family//Glucose inhibited division protein A//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain GO:0008033//GO:0015684//GO:0055114 tRNA processing//ferrous iron transport//oxidation-reduction process GO:0008641//GO:0050660//GO:0016491//GO:0071949//GO:0015093 small protein activating enzyme activity//flavin adenine dinucleotide binding//oxidoreductase activity//FAD binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.45606 BP_3 75.27 0.41 9071 642933690 XP_008197522.1 457 6.0e-42 PREDICTED: golgin subfamily A member 4-like [Tribolium castaneum]>gi|270012607|gb|EFA09055.1| hypothetical protein TcasGA2_TC006768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 227 1.2e-16 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF02179//PF04048 BAG domain//Sec8 exocyst complex component specific domain GO:0015031//GO:0006904 protein transport//vesicle docking involved in exocytosis GO:0051087 chaperone binding GO:0000145 exocyst -- -- Cluster-8309.45609 BP_3 1088.77 14.39 3938 91081191 XP_975602.1 3797 0.0e+00 PREDICTED: N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2 [Tribolium castaneum]>gi|270006047|gb|EFA02495.1| hypothetical protein TcasGA2_TC008190 [Tribolium castaneum] 642920290 XM_970509.2 763 0 PREDICTED: Tribolium castaneum N-alpha-acetyltransferase 16, NatA auxiliary subunit (LOC664508), transcript variant X3, mRNA K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 Q5R4J9 2511 7.2e-282 N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Pongo abelii GN=NAA15 PE=2 SV=1 PF13371//PF00515//PF13414//PF13176//PF06552//PF03601//PF13181//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Plant specific mitochondrial import receptor subunit TOM20//Conserved hypothetical protein 698//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0045040 protein import into mitochondrial outer membrane GO:0005515 protein binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane KOG1156 N-terminal acetyltransferase Cluster-8309.45610 BP_3 44.00 2.78 1055 270010513 EFA06961.1 680 9.7e-69 hypothetical protein TcasGA2_TC009919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03568 Peptidase family C50 GO:0006508 proteolysis GO:0008233 peptidase activity GO:0005634 nucleus -- -- Cluster-8309.45611 BP_3 39.00 2.85 951 642929360 XP_008195803.1 784 7.6e-81 PREDICTED: separin [Tribolium castaneum] -- -- -- -- -- K02365 ESP1 separase http://www.genome.jp/dbget-bin/www_bget?ko:K02365 P60330 267 2.8e-22 Separin OS=Mus musculus GN=Espl1 PE=1 SV=1 PF03568 Peptidase family C50 GO:0006508 proteolysis GO:0008233 peptidase activity GO:0005634 nucleus KOG1849 Regulator of spindle pole body duplication Cluster-8309.45613 BP_3 796.86 14.57 2928 281369846 BAI59107.1 972 3.7e-102 serpin55 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q1JPB0 246 2.3e-19 Leukocyte elastase inhibitor OS=Bos taurus GN=SERPINB1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.45615 BP_3 140.82 0.95 7470 662212467 XP_008479970.1 158 2.3e-07 PREDICTED: zinc finger protein 425-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF04810//PF00412//PF13912//PF01155//PF00096//PF13465 zinc-finger C2H2-type//Sec23/Sec24 zinc finger//LIM domain//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006886//GO:0006888//GO:0006464 intracellular protein transport//ER to Golgi vesicle-mediated transport//cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.45617 BP_3 56.83 2.66 1322 478257606 ENN77758.1 157 5.4e-08 hypothetical protein YQE_05730, partial [Dendroctonus ponderosae]>gi|546677510|gb|ERL88336.1| hypothetical protein D910_05723 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45619 BP_3 520.57 19.33 1590 91087061 XP_974794.1 1218 6.0e-131 PREDICTED: retrograde Golgi transport protein RGP1 homolog [Tribolium castaneum]>gi|270010531|gb|EFA06979.1| hypothetical protein TcasGA2_TC009939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92546 492 3.8e-48 RAB6A-GEF complex partner protein 2 OS=Homo sapiens GN=RGP1 PE=1 SV=1 PF04216 Protein involved in formate dehydrogenase formation -- -- -- -- GO:0005737 cytoplasm KOG4469 Uncharacterized conserved protein Cluster-8309.45620 BP_3 164.86 6.37 1539 91076824 XP_967870.1 885 2.4e-92 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 565 1.3e-56 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.45621 BP_3 505.21 18.76 1590 741829289 AJA91071.1 1030 3.8e-109 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 738 1.1e-76 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.45622 BP_3 208.18 1.56 6740 478260037 ENN79822.1 2213 1.1e-245 hypothetical protein YQE_03645, partial [Dendroctonus ponderosae] 642918140 XM_008193162.1 193 1.58161e-93 PREDICTED: Tribolium castaneum ATP-dependent DNA helicase Q4 (LOC655929), mRNA K10730 RECQL4 ATP-dependent DNA helicase Q4 http://www.genome.jp/dbget-bin/www_bget?ko:K10730 Q75NR7 1081 8.1e-116 ATP-dependent DNA helicase Q4 OS=Mus musculus GN=Recql4 PE=2 SV=2 PF00098//PF00437//PF06414//PF02367//PF03193//PF00485//PF00270//PF00503 Zinc knuckle//Type II/IV secretion system protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//Phosphoribulokinase / Uridine kinase family//DEAD/DEAH box helicase//G-protein alpha subunit GO:0006810//GO:0008152//GO:0007165//GO:0007186//GO:0002949 transport//metabolic process//signal transduction//G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0031683//GO:0005524//GO:0004871//GO:0019001//GO:0003676//GO:0016301//GO:0008270//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//ATP binding//signal transducer activity//guanyl nucleotide binding//nucleic acid binding//kinase activity//zinc ion binding//GTP binding -- -- KOG0351 ATP-dependent DNA helicase Cluster-8309.45625 BP_3 76.38 2.44 1803 642928935 XP_008195623.1 238 3.0e-17 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9VCX1 139 3.7e-07 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 -- -- GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.45626 BP_3 371.65 5.55 3517 642912272 XP_008200632.1 770 1.2e-78 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 8.7e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF01414//PF00089 Delta serrate ligand//Trypsin GO:0006508//GO:0007154 proteolysis//cell communication GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.45627 BP_3 4.26 0.31 951 270008952 EFA05400.1 456 8.2e-43 hypothetical protein TcasGA2_TC015572 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 284 3.0e-24 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45628 BP_3 247.00 4.68 2835 91082797 XP_967743.1 715 2.3e-72 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BXC6 372 5.5e-34 COMM domain-containing protein 2 OS=Mus musculus GN=Commd2 PE=1 SV=1 PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.45629 BP_3 49.00 4.78 786 546682961 ERL92838.1 1171 8.4e-126 hypothetical protein D910_10145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9UM47 242 1.8e-19 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.45632 BP_3 308.49 1.79 8592 642918656 XP_008191524.1 2229 1.9e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.3e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF07535//PF06220//PF00463//PF00069//PF01799//PF00433//PF07714 DBF zinc finger//U1 zinc finger//Isocitrate lyase family//Protein kinase domain//[2Fe-2S] binding domain//Protein kinase C terminal domain//Protein tyrosine kinase GO:0019752//GO:0016310//GO:0009069//GO:0006468//GO:0006097//GO:0055114 carboxylic acid metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//glyoxylate cycle//oxidation-reduction process GO:0004451//GO:0016491//GO:0005543//GO:0005524//GO:0046872//GO:0004674//GO:0004672//GO:0003676//GO:0008270 isocitrate lyase activity//oxidoreductase activity//phospholipid binding//ATP binding//metal ion binding//protein serine/threonine kinase activity//protein kinase activity//nucleic acid binding//zinc ion binding -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.45634 BP_3 303.79 10.92 1633 282158103 NP_001164095.1 1643 3.2e-180 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.78039e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1360 8.7e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF06273//PF03141//PF04851 DEAD/DEAH box helicase//Plant specific eukaryotic initiation factor 4B//Putative S-adenosyl-L-methionine-dependent methyltransferase//Type III restriction enzyme, res subunit GO:0006446 regulation of translational initiation GO:0003743//GO:0016787//GO:0003677//GO:0005524//GO:0003676//GO:0008168 translation initiation factor activity//hydrolase activity//DNA binding//ATP binding//nucleic acid binding//methyltransferase activity GO:0005840 ribosome KOG0331 ATP-dependent RNA helicase Cluster-8309.45635 BP_3 457.43 12.73 2024 -- -- -- -- -- 327302703 XM_003235996.1 43 1.13835e-10 Trichophyton rubrum CBS 118892 hypothetical protein (TERG_08771) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45639 BP_3 303.32 4.67 3425 642937037 XP_008198662.1 2915 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X3 [Tribolium castaneum] 642937036 XM_008200440.1 584 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X3, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 2063 5.5e-230 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF11540//PF09266//PF00400 Cytoplasmic dynein 1 intermediate chain 2//Viral DNA topoisomerase I, N-terminal//WD domain, G-beta repeat GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0003916//GO:0005515//GO:0003677 DNA topoisomerase activity//protein binding//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.45640 BP_3 35.00 1.34 1546 307168739 EFN61742.1 152 2.4e-07 hypothetical protein EAG_13055, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45641 BP_3 20.95 0.37 2996 332375280 AEE62781.1 555 8.6e-54 unknown [Dendroctonus ponderosae]>gi|478256834|gb|ENN77009.1| hypothetical protein YQE_06503, partial [Dendroctonus ponderosae] 815824285 XM_012378064.1 88 1.63469e-35 PREDICTED: Linepithema humile dnaJ homolog subfamily C member 8 (LOC105678594), mRNA K09528 DNAJC8 DnaJ homolog subfamily C member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09528 O75937 382 4.1e-35 DnaJ homolog subfamily C member 8 OS=Homo sapiens GN=DNAJC8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1150 Predicted molecular chaperone (DnaJ superfamily) Cluster-8309.45642 BP_3 95.41 1.17 4239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF05485 Zinc-finger associated domain (zf-AD)//THAP domain -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45644 BP_3 15.21 0.53 1683 642926286 XP_008194862.1 1484 9.1e-162 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like [Tribolium castaneum] 642926285 XM_008196640.1 273 1.31312e-138 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1076 7.7e-116 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.45646 BP_3 25.51 0.76 1904 642910558 XP_008200265.1 957 1.3e-100 PREDICTED: ras-related protein Rab6 isoform X2 [Tribolium castaneum]>gi|270014377|gb|EFA10825.1| hypothetical protein TcasGA2_TC001600 [Tribolium castaneum] 676425887 XM_009046199.1 171 7.48935e-82 Lottia gigantea hypothetical protein mRNA K07893 RAB6A Ras-related protein Rab-6A http://www.genome.jp/dbget-bin/www_bget?ko:K07893 O18334 933 3.3e-99 Ras-related protein Rab6 OS=Drosophila melanogaster GN=Rab6 PE=1 SV=1 PF08477//PF01926//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0015031//GO:0007264 protein transport//small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily Cluster-8309.45648 BP_3 9.00 1.39 604 546678920 ERL89458.1 167 1.7e-09 hypothetical protein D910_06825 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF02892//PF00096//PF13465 Kazal-type serine protease inhibitor domain//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0005515//GO:0046872//GO:0003677 protein binding//metal ion binding//DNA binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.45649 BP_3 468.69 3.26 7225 642930298 XP_008196335.1 3056 0.0e+00 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1 [Tribolium castaneum] 642930305 XM_008198117.1 1318 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 Q9UL51 1577 2.6e-173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens GN=HCN2 PE=1 SV=3 PF01676//PF00520 Metalloenzyme superfamily//Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0003824//GO:0005216//GO:0046872 catalytic activity//ion channel activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.45651 BP_3 121.62 2.87 2332 91081173 XP_975583.1 1226 1.0e-131 PREDICTED: mitochondrial 2-oxodicarboxylate carrier [Tribolium castaneum]>gi|270006043|gb|EFA02491.1| hypothetical protein TcasGA2_TC008186 [Tribolium castaneum] -- -- -- -- -- K15110 SLC25A21, ODC solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15110 Q9BQT8 888 6.7e-94 Mitochondrial 2-oxodicarboxylate carrier OS=Homo sapiens GN=SLC25A21 PE=1 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0754 Mitochondrial oxodicarboxylate carrier protein Cluster-8309.45655 BP_3 1012.00 96.92 795 478256590 ENN76772.1 465 6.2e-44 hypothetical protein YQE_06613, partial [Dendroctonus ponderosae] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q45VV3 215 2.5e-16 Transcriptional coactivator yorkie OS=Drosophila melanogaster GN=yki PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45656 BP_3 1030.18 19.89 2788 642911706 XP_008200710.1 705 3.2e-71 PREDICTED: yorkie homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q9EPK5 283 1.1e-23 WW domain-containing transcription regulator protein 1 OS=Mus musculus GN=Wwtr1 PE=1 SV=2 PF00397//PF03153 WW domain//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0005515 protein binding GO:0005672 transcription factor TFIIA complex KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.45657 BP_3 6.88 0.36 1214 91076148 XP_970492.1 742 7.2e-76 PREDICTED: yorkie homolog isoform X1 [Tribolium castaneum]>gi|270014715|gb|EFA11163.1| hypothetical protein TcasGA2_TC004769 [Tribolium castaneum] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q45VV3 309 4.8e-27 Transcriptional coactivator yorkie OS=Drosophila melanogaster GN=yki PE=1 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.45658 BP_3 258.98 3.12 4298 91089273 XP_966340.1 958 2.3e-100 PREDICTED: autophagy-related protein 101 [Tribolium castaneum]>gi|270011443|gb|EFA07891.1| hypothetical protein TcasGA2_TC005466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH75 708 9.2e-73 Autophagy-related protein 101 OS=Xenopus tropicalis GN=atg101 PE=2 SV=1 PF02907 Hepatitis C virus NS3 protease GO:0006508//GO:0019087 proteolysis//transformation of host cell by virus GO:0008236 serine-type peptidase activity -- -- KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.45659 BP_3 312.39 5.19 3194 91092536 XP_967769.1 2382 1.3e-265 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 515 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1611 1.3e-177 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.45660 BP_3 20.00 2.48 681 546681776 ERL91802.1 199 3.7e-13 hypothetical protein D910_09127 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45661 BP_3 202.96 2.84 3734 91080499 XP_971142.1 1091 7.5e-116 PREDICTED: 5'-AMP-activated protein kinase subunit beta-1 [Tribolium castaneum]>gi|270005556|gb|EFA02004.1| hypothetical protein TcasGA2_TC007626 [Tribolium castaneum] 332376520 BT128443.1 148 9.04263e-69 Dendroctonus ponderosae clone DPO1136_F01 unknown mRNA K07199 PRKAB 5'-AMP-activated protein kinase, regulatory beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07199 Q5BIS9 672 1.2e-68 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus GN=PRKAB1 PE=2 SV=3 PF02892//PF04739//PF13912//PF00320//PF16622//PF13465//PF05443//PF02922//PF07503//PF00096 BED zinc finger//5'-AMP-activated protein kinase beta subunit, interaction domain//C2H2-type zinc finger//GATA zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//HypF finger//Zinc finger, C2H2 type GO:0006355//GO:0005975 regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0004553//GO:0003677//GO:0005515//GO:0008270//GO:0043565//GO:0046872//GO:0003700 hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding//protein binding//zinc ion binding//sequence-specific DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1616 Protein involved in Snf1 protein kinase complex assembly Cluster-8309.45662 BP_3 484.65 5.70 4391 332376575 AEE63427.1 1298 8.8e-140 unknown [Dendroctonus ponderosae]>gi|546673735|gb|ERL85291.1| hypothetical protein D910_02712 [Dendroctonus ponderosae] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q5FWL7 826 1.9e-86 Palmitoyltransferase ZDHHC15 OS=Xenopus laevis GN=zdhhc15 PE=2 SV=1 PF00219//PF01529//PF01309//PF02714 Insulin-like growth factor binding protein//DHHC palmitoyltransferase//Equine arteritis virus small envelope glycoprotein//Calcium-dependent channel, 7TM region, putative phosphate GO:0001558 regulation of cell growth GO:0005520//GO:0008270 insulin-like growth factor binding//zinc ion binding GO:0016942//GO:0019031//GO:0016020//GO:0005576 insulin-like growth factor binding protein complex//viral envelope//membrane//extracellular region KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.45663 BP_3 62.03 0.70 4542 332376575 AEE63427.1 1358 1.0e-146 unknown [Dendroctonus ponderosae]>gi|546673735|gb|ERL85291.1| hypothetical protein D910_02712 [Dendroctonus ponderosae] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q5FWL7 833 3.1e-87 Palmitoyltransferase ZDHHC15 OS=Xenopus laevis GN=zdhhc15 PE=2 SV=1 PF02714//PF01309//PF01529//PF00219 Calcium-dependent channel, 7TM region, putative phosphate//Equine arteritis virus small envelope glycoprotein//DHHC palmitoyltransferase//Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0008270//GO:0005520 zinc ion binding//insulin-like growth factor binding GO:0005576//GO:0016020//GO:0019031//GO:0016942 extracellular region//membrane//viral envelope//insulin-like growth factor binding protein complex KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.45666 BP_3 86.77 1.49 3098 642930161 XP_008196278.1 3054 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [Tribolium castaneum]>gi|642930163|ref|XP_008196279.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [Tribolium castaneum]>gi|642930165|ref|XP_008196280.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 6.0e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00989//PF00072//PF05504//PF00233//PF09771 PAS fold//Response regulator receiver domain//Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188 GO:0006144//GO:0000160//GO:0035307//GO:0007165//GO:0009847//GO:0006355 purine nucleobase metabolic process//phosphorelay signal transduction system//positive regulation of protein dephosphorylation//signal transduction//spore germination//regulation of transcription, DNA-templated GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.45668 BP_3 513.80 2.33 10916 642940144 XP_008200104.1 3309 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H269 1673 2.9e-184 Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens GN=VPS16 PE=1 SV=2 PF04840//PF04841 Vps16, C-terminal region//Vps16, N-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.45669 BP_3 7.03 1.25 563 478263360 ENN81736.1 389 2.9e-35 hypothetical protein YQE_01875, partial [Dendroctonus ponderosae]>gi|546681308|gb|ERL91422.1| hypothetical protein D910_08754 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.4567 BP_3 42.42 0.46 4694 642917080 XP_008191110.1 1932 2.9e-213 PREDICTED: kinesin-like protein KIF18A isoform X2 [Tribolium castaneum] -- -- -- -- -- K10401 KIF18_19 kinesin family member 18/19 http://www.genome.jp/dbget-bin/www_bget?ko:K10401 Q8NI77 1056 4.5e-113 Kinesin-like protein KIF18A OS=Homo sapiens GN=KIF18A PE=1 SV=2 PF02245//PF00225//PF04923 Methylpurine-DNA glycosylase (MPG)//Kinesin motor domain//Ninjurin GO:0006284//GO:0007018//GO:0042246//GO:0007155//GO:0007017 base-excision repair//microtubule-based movement//tissue regeneration//cell adhesion//microtubule-based process GO:0003677//GO:0003905//GO:0005524//GO:0003777//GO:0008017 DNA binding//alkylbase DNA N-glycosylase activity//ATP binding//microtubule motor activity//microtubule binding GO:0016021//GO:0045298//GO:0005874 integral component of membrane//tubulin complex//microtubule KOG0242 Kinesin-like protein Cluster-8309.45671 BP_3 128.64 1.73 3881 91090029 XP_967684.1 2946 0.0e+00 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270013527|gb|EFA09975.1| hypothetical protein TcasGA2_TC012134 [Tribolium castaneum] 462277993 APGK01058794.1 35 6.15996e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 1000 1.1e-106 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553//PF00620 Acyltransferase//RhoGAP domain GO:0046486//GO:0008654//GO:0008152//GO:0007165//GO:0042967 glycerolipid metabolic process//phospholipid biosynthetic process//metabolic process//signal transduction//acyl-carrier-protein biosynthetic process GO:0016746//GO:0004366 transferase activity, transferring acyl groups//glycerol-3-phosphate O-acyltransferase activity GO:0016020 membrane KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.45672 BP_3 1183.84 34.06 1967 189237918 XP_001811805.1 2207 1.5e-245 PREDICTED: transcription initiation factor TFIID subunit 6 [Tribolium castaneum]>gi|270006675|gb|EFA03123.1| hypothetical protein TcasGA2_TC013033 [Tribolium castaneum] 762091727 XM_011429969.1 66 1.81142e-23 PREDICTED: Crassostrea gigas transcription initiation factor TFIID subunit 6-like (LOC105328924), mRNA K03131 TAF6 transcription initiation factor TFIID subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03131 P49847 1590 2.2e-175 Transcription initiation factor TFIID subunit 6 OS=Drosophila melanogaster GN=Taf6 PE=1 SV=2 PF08769//PF00125//PF07571//PF02969 Sporulation initiation factor Spo0A C terminal//Core histone H2A/H2B/H3/H4//TAF6 C-terminal HEAT repeat domain//TATA box binding protein associated factor (TAF) GO:0051090//GO:0006352//GO:0042173//GO:0006355 regulation of sequence-specific DNA binding transcription factor activity//DNA-templated transcription, initiation//regulation of sporulation resulting in formation of a cellular spore//regulation of transcription, DNA-templated GO:0046982//GO:0003677//GO:0003700//GO:0005509 protein heterodimerization activity//DNA binding//transcription factor activity, sequence-specific DNA binding//calcium ion binding GO:0005667//GO:0005634//GO:0005737 transcription factor complex//nucleus//cytoplasm KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.45676 BP_3 754.83 8.09 4790 642918008 XP_008198978.1 844 4.2e-87 PREDICTED: E3 ubiquitin-protein ligase rnf146 [Tribolium castaneum] -- -- -- -- -- K15700 RNF146 E3 ubiquitin-protein ligase RNF146 http://www.genome.jp/dbget-bin/www_bget?ko:K15700 Q5XIK5 576 2.1e-57 E3 ubiquitin-protein ligase RNF146 OS=Rattus norvegicus GN=Rnf146 PE=2 SV=1 PF08445//PF13302//PF13508//PF00583//PF13639//PF16685//PF12678//PF14634//PF00097//PF13673 FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Ring finger domain//zinc RING finger of MSL2//RING-H2 zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0046872//GO:0005515//GO:0061630//GO:0008080//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//metal ion binding//protein binding//ubiquitin protein ligase activity//N-acetyltransferase activity//zinc ion binding -- -- KOG0824 Predicted E3 ubiquitin ligase Cluster-8309.4568 BP_3 6.00 0.59 786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45680 BP_3 77.18 7.42 793 642928567 XP_008199961.1 327 6.2e-28 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 Q9VVR9 212 5.5e-16 Probable cytochrome P450 12c1, mitochondrial OS=Drosophila melanogaster GN=Cyp12c1 PE=2 SV=2 PF11057//PF00067 Cortexin of kidney//Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0031224 intrinsic component of membrane -- -- Cluster-8309.45683 BP_3 203.94 0.91 11106 642922880 XP_008200435.1 6092 0.0e+00 PREDICTED: maestro heat-like repeat-containing protein family member 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDA8 1449 2.8e-158 Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens GN=MROH1 PE=2 SV=3 PF00628//PF01429//PF02985//PF05485//PF00096//PF07178//PF11698 PHD-finger//Methyl-CpG binding domain//HEAT repeat//THAP domain//Zinc finger, C2H2 type//TraL protein//V-ATPase subunit H GO:0000746//GO:0015991 conjugation//ATP hydrolysis coupled proton transport GO:0046872//GO:0003676//GO:0005515//GO:0016820//GO:0003677 metal ion binding//nucleic acid binding//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//DNA binding GO:0000221//GO:0005634//GO:0019867 vacuolar proton-transporting V-type ATPase, V1 domain//nucleus//outer membrane KOG2032 Uncharacterized conserved protein Cluster-8309.45684 BP_3 770.20 3.46 11026 642922880 XP_008200435.1 5420 0.0e+00 PREDICTED: maestro heat-like repeat-containing protein family member 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDA8 1179 5.7e-127 Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens GN=MROH1 PE=2 SV=3 PF05485//PF02985//PF10288//PF01429//PF11698//PF00628//PF00096//PF07178 THAP domain//HEAT repeat//Cytoplasmic tRNA 2-thiolation protein 2//Methyl-CpG binding domain//V-ATPase subunit H//PHD-finger//Zinc finger, C2H2 type//TraL protein GO:0002098//GO:0015991//GO:0034227//GO:0000746 tRNA wobble uridine modification//ATP hydrolysis coupled proton transport//tRNA thio-modification//conjugation GO:0016820//GO:0000049//GO:0005515//GO:0003677//GO:0046872//GO:0003676 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//tRNA binding//protein binding//DNA binding//metal ion binding//nucleic acid binding GO:0000221//GO:0005634//GO:0019867 vacuolar proton-transporting V-type ATPase, V1 domain//nucleus//outer membrane KOG2032 Uncharacterized conserved protein Cluster-8309.45685 BP_3 359.37 6.18 3096 332375600 AEE62941.1 1416 1.3e-153 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7T3C7 340 3.1e-30 Reticulon-4-interacting protein 1 homolog, mitochondrial OS=Danio rerio GN=rtn4ip1 PE=2 SV=2 PF08240 Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process -- -- -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.45687 BP_3 34.34 0.49 3698 642921224 XP_008192769.1 1938 4.5e-214 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921223 XM_008194547.1 369 0 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X1, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 652 2.5e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF00023//PF14604//PF00018//PF13606 Ankyrin repeat//Variant SH3 domain//SH3 domain//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.45690 BP_3 1415.37 6.06 11557 642917448 XP_008191204.1 2643 2.5e-295 PREDICTED: maternal protein tudor isoform X3 [Tribolium castaneum] -- -- -- -- -- K11457 PHC2, EDR2 polyhomeotic-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11457 P25823 542 4.4e-53 Maternal protein tudor OS=Drosophila melanogaster GN=tud PE=1 SV=2 PF02198//PF00536//PF07647 Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515//GO:0043565 protein binding//sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.45692 BP_3 123.37 6.90 1153 589939228 XP_006982360.1 507 1.2e-48 PREDICTED: zinc finger protein 658B-like [Peromyscus maniculatus bairdii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q52M93 479 8.8e-47 Zinc finger protein 585B OS=Homo sapiens GN=ZNF585B PE=2 SV=1 PF13465//PF07975//PF13912//PF16622//PF00096//PF01155//PF00130//PF06467//PF07776 Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD) GO:0035556//GO:0006281//GO:0006464 intracellular signal transduction//DNA repair//cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45694 BP_3 7.22 0.45 1069 282158087 NP_001164087.1 289 2.1e-23 zinc finger protein TC009514 [Tribolium castaneum]>gi|270010151|gb|EFA06599.1| hypothetical protein TcasGA2_TC009514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45698 BP_3 196.14 2.73 3759 546679853 ERL90241.1 1277 2.0e-137 hypothetical protein D910_07594 [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 700 6.8e-72 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF16782//PF00916 Nucleotide exchange factor SIL1//Sulfate permease family GO:0008272 sulfate transport GO:0015116//GO:0000774 sulfate transmembrane transporter activity//adenyl-nucleotide exchange factor activity GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.45699 BP_3 1648.43 18.80 4517 642914389 XP_008201657.1 2629 4.1e-294 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K08836 SLK STE20-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08836 O54988 1025 1.7e-109 STE20-like serine/threonine-protein kinase OS=Mus musculus GN=Slk PE=1 SV=2 PF00069//PF07714//PF12474 Protein kinase domain//Protein tyrosine kinase//Polo kinase kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004674//GO:0004672//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//ATP binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.457 BP_3 6.60 0.35 1194 642920497 XP_008192376.1 1291 1.5e-139 PREDICTED: head-specific guanylate cyclase [Tribolium castaneum]>gi|270005900|gb|EFA02348.1| hypothetical protein TcasGA2_TC008018 [Tribolium castaneum] 755945261 XM_011301432.1 164 3.61574e-78 PREDICTED: Fopius arisanus head-specific guanylate cyclase (LOC105264506), mRNA K12318 GUCY1A guanylate cyclase soluble subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K12318 Q07093 1002 2.1e-107 Head-specific guanylate cyclase OS=Drosophila melanogaster GN=Gycalpha99B PE=2 SV=2 PF00211//PF00522//PF07701//PF07429//PF04464 Adenylate and Guanylate cyclase catalytic domain//VPR/VPX protein//Heme NO binding associated//4-alpha-L-fucosyltransferase glycosyl transferase group 56//CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase GO:0046039//GO:0009190//GO:0035556//GO:0009246//GO:0006144//GO:0019058//GO:0006182//GO:0036065 GTP metabolic process//cyclic nucleotide biosynthetic process//intracellular signal transduction//enterobacterial common antigen biosynthetic process//purine nucleobase metabolic process//viral life cycle//cGMP biosynthetic process//fucosylation GO:0004383//GO:0000166//GO:0008417//GO:0016849//GO:0020037//GO:0047355 guanylate cyclase activity//nucleotide binding//fucosyltransferase activity//phosphorus-oxygen lyase activity//heme binding//CDP-glycerol glycerophosphotransferase activity GO:0042025//GO:0005622//GO:0016020 host cell nucleus//intracellular//membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.45700 BP_3 51.94 1.11 2541 817078465 XP_012261606.1 796 8.2e-82 PREDICTED: uncharacterized protein LOC105689268 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF00628//PF03184 helix-turn-helix, Psq domain//PHD-finger//DDE superfamily endonuclease -- -- GO:0005515//GO:0003677//GO:0003676 protein binding//DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.45701 BP_3 143.07 16.49 710 91079879 XP_975774.1 464 7.2e-44 PREDICTED: uncharacterized protein LOC655985 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06220//PF04889 U1 zinc finger//Cwf15/Cwc15 cell cycle control protein GO:0000398 mRNA splicing, via spliceosome GO:0008270 zinc ion binding GO:0005681 spliceosomal complex -- -- Cluster-8309.45703 BP_3 264.61 11.33 1417 91094297 XP_971720.1 1187 2.1e-127 PREDICTED: estradiol 17-beta-dehydrogenase 12 [Tribolium castaneum]>gi|270014405|gb|EFA10853.1| hypothetical protein TcasGA2_TC001630 [Tribolium castaneum] -- -- -- -- -- K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10251 Q28IU1 690 3.7e-71 Very-long-chain 3-oxoacyl-CoA reductase OS=Xenopus tropicalis GN=hsd17b12 PE=2 SV=1 PF00106//PF02737//PF03435//PF01370//PF10461//PF02882 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family//Peptidase S68//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0006550//GO:0006574//GO:0046487//GO:0009396//GO:0006974//GO:0006568//GO:0006915//GO:0006554//GO:0055114//GO:0008152//GO:0006633//GO:0018874//GO:0006631//GO:0006552 isoleucine catabolic process//valine catabolic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//cellular response to DNA damage stimulus//tryptophan metabolic process//apoptotic process//lysine catabolic process//oxidation-reduction process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//fatty acid metabolic process//leucine catabolic process GO:0050662//GO:0004488//GO:0000166//GO:0003857//GO:0003824//GO:0016491 coenzyme binding//methylenetetrahydrofolate dehydrogenase (NADP+) activity//nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity//catalytic activity//oxidoreductase activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.45706 BP_3 127.87 2.05 3302 478256573 ENN76755.1 1419 6.2e-154 hypothetical protein YQE_06596, partial [Dendroctonus ponderosae] -- -- -- -- -- K11652 ACTL6B actin-like protein 6B http://www.genome.jp/dbget-bin/www_bget?ko:K11652 Q99MR0 773 2.0e-80 Actin-like protein 6B OS=Mus musculus GN=Actl6b PE=1 SV=1 PF07690//PF02487 Major Facilitator Superfamily//CLN3 protein GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG3880 Predicted small molecule transporter involved in cellular pH homeostasis (Batten disease protein in human) Cluster-8309.45707 BP_3 564.30 3.25 8668 642916202 XP_008190929.1 540 1.4e-51 PREDICTED: uncharacterized protein LOC103312333 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q59SG9 137 3.0e-06 Probable GPI-anchored adhesin-like protein PGA55 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PGA55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45708 BP_3 1072.37 8.86 6126 642916202 XP_008190929.1 462 1.1e-42 PREDICTED: uncharacterized protein LOC103312333 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q59SG9 137 2.1e-06 Probable GPI-anchored adhesin-like protein PGA55 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PGA55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45711 BP_3 124.48 1.07 5892 546679844 ERL90232.1 1077 5.0e-114 hypothetical protein D910_07585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 554 9.1e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228//PF01157//PF03561 Stage II sporulation protein E (SpoIIE)//Ribosomal protein L21e//Allantoicase repeat GO:0006807//GO:0042254//GO:0000256//GO:0006412//GO:0006144 nitrogen compound metabolic process//ribosome biogenesis//allantoin catabolic process//translation//purine nucleobase metabolic process GO:0003735//GO:0004037//GO:0003824 structural constituent of ribosome//allantoicase activity//catalytic activity GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.45714 BP_3 342.41 6.93 2674 332376166 AEE63223.1 796 8.7e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q86BN8 611 1.0e-61 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Drosophila melanogaster GN=Plip PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1719 Dual specificity phosphatase Cluster-8309.45715 BP_3 65.00 6.97 741 642929725 XP_975551.3 737 1.7e-75 PREDICTED: nuclear pore complex protein Nup133 [Tribolium castaneum] -- -- -- -- -- K14300 NUP133 nuclear pore complex protein Nup133 http://www.genome.jp/dbget-bin/www_bget?ko:K14300 Q8R0G9 187 4.1e-13 Nuclear pore complex protein Nup133 OS=Mus musculus GN=Nup133 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45716 BP_3 59.25 0.43 6915 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.55062e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF05201//PF03178 Glutamyl-tRNAGlu reductase, N-terminal domain//CPSF A subunit region GO:0033014//GO:0055114 tetrapyrrole biosynthetic process//oxidation-reduction process GO:0003676//GO:0050661//GO:0008883 nucleic acid binding//NADP binding//glutamyl-tRNA reductase activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.45717 BP_3 115.12 0.85 6783 91087281 XP_975549.1 5025 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.40571e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 3976 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF03178//PF05201 CPSF A subunit region//Glutamyl-tRNAGlu reductase, N-terminal domain GO:0033014//GO:0055114 tetrapyrrole biosynthetic process//oxidation-reduction process GO:0003676//GO:0050661//GO:0008883 nucleic acid binding//NADP binding//glutamyl-tRNA reductase activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.45718 BP_3 109.90 0.86 6441 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.03026e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF03178//PF05201 CPSF A subunit region//Glutamyl-tRNAGlu reductase, N-terminal domain GO:0033014//GO:0055114 tetrapyrrole biosynthetic process//oxidation-reduction process GO:0003676//GO:0050661//GO:0008883 nucleic acid binding//NADP binding//glutamyl-tRNA reductase activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.45719 BP_3 146.42 1.10 6724 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.34094e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF03178//PF05201 CPSF A subunit region//Glutamyl-tRNAGlu reductase, N-terminal domain GO:0055114//GO:0033014 oxidation-reduction process//tetrapyrrole biosynthetic process GO:0003676//GO:0050661//GO:0008883 nucleic acid binding//NADP binding//glutamyl-tRNA reductase activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.45720 BP_3 1417.37 10.78 6631 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.23884e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF03178//PF05201 CPSF A subunit region//Glutamyl-tRNAGlu reductase, N-terminal domain GO:0033014//GO:0055114 tetrapyrrole biosynthetic process//oxidation-reduction process GO:0008883//GO:0050661//GO:0003676 glutamyl-tRNA reductase activity//NADP binding//nucleic acid binding GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.45723 BP_3 31.77 0.63 2716 642924566 XP_008194346.1 1572 9.2e-172 PREDICTED: endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform X1 [Tribolium castaneum]>gi|270007946|gb|EFA04394.1| hypothetical protein TcasGA2_TC014693 [Tribolium castaneum] 827553572 XM_004929230.2 77 1.92817e-29 PREDICTED: Bombyx mori endoplasmic reticulum-Golgi intermediate compartment protein 3 (LOC101741074), mRNA -- -- -- -- Q803I2 1024 1.3e-109 Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Danio rerio GN=ergic3 PE=2 SV=1 PF04124//PF04976 Dor1-like family//DMSO reductase anchor subunit (DmsC) GO:0019645 anaerobic electron transport chain -- -- GO:0017119//GO:0016021 Golgi transport complex//integral component of membrane KOG2667 COPII vesicle protein Cluster-8309.45724 BP_3 16.46 0.31 2815 642924566 XP_008194346.1 1572 9.5e-172 PREDICTED: endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform X1 [Tribolium castaneum]>gi|270007946|gb|EFA04394.1| hypothetical protein TcasGA2_TC014693 [Tribolium castaneum] 827553572 XM_004929230.2 77 1.9994e-29 PREDICTED: Bombyx mori endoplasmic reticulum-Golgi intermediate compartment protein 3 (LOC101741074), mRNA -- -- -- -- Q803I2 1024 1.4e-109 Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Danio rerio GN=ergic3 PE=2 SV=1 PF01544//PF04976 CorA-like Mg2+ transporter protein//DMSO reductase anchor subunit (DmsC) GO:0030001//GO:0055085//GO:0019645 metal ion transport//transmembrane transport//anaerobic electron transport chain GO:0046873 metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2667 COPII vesicle protein Cluster-8309.45726 BP_3 149.88 8.75 1117 189237923 XP_001810409.1 1254 2.8e-135 PREDICTED: exocyst complex component 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ43 482 3.8e-47 Exocyst complex component 8 OS=Gallus gallus GN=EXOC8 PE=2 SV=1 PF07578//PF02902 Lipid A Biosynthesis N-terminal domain//Ulp1 protease family, C-terminal catalytic domain GO:0006508//GO:0009245 proteolysis//lipid A biosynthetic process GO:0008915//GO:0008234 lipid-A-disaccharide synthase activity//cysteine-type peptidase activity -- -- KOG2215 Exocyst complex subunit Cluster-8309.45727 BP_3 65.28 1.27 2763 642924566 XP_008194346.1 1572 9.3e-172 PREDICTED: endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform X1 [Tribolium castaneum]>gi|270007946|gb|EFA04394.1| hypothetical protein TcasGA2_TC014693 [Tribolium castaneum] 827553572 XM_004929230.2 77 1.96198e-29 PREDICTED: Bombyx mori endoplasmic reticulum-Golgi intermediate compartment protein 3 (LOC101741074), mRNA -- -- -- -- Q803I2 1024 1.3e-109 Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Danio rerio GN=ergic3 PE=2 SV=1 PF04976//PF07749 DMSO reductase anchor subunit (DmsC)//Endoplasmic reticulum protein ERp29, C-terminal domain GO:0019645 anaerobic electron transport chain -- -- GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG2667 COPII vesicle protein Cluster-8309.45729 BP_3 22.74 1.00 1392 270001240 EEZ97687.1 703 2.7e-71 hypothetical protein TcasGA2_TC016235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4U9 521 1.4e-51 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.45731 BP_3 381.76 16.51 1406 270001240 EEZ97687.1 703 2.8e-71 hypothetical protein TcasGA2_TC016235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4U9 521 1.4e-51 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.45732 BP_3 484.71 13.57 2014 546674618 ERL85967.1 1881 1.0e-207 hypothetical protein D910_03382 [Dendroctonus ponderosae] 612023545 XM_007491044.1 107 2.99698e-46 PREDICTED: Monodelphis domestica ClpB caseinolytic peptidase B homolog (E. coli) (CLPB), transcript variant X4, mRNA K03695 clpB ATP-dependent Clp protease ATP-binding subunit ClpB http://www.genome.jp/dbget-bin/www_bget?ko:K03695 Q60649 1468 3.2e-161 Caseinolytic peptidase B protein homolog OS=Mus musculus GN=Clpb PE=1 SV=1 PF00005//PF00023//PF07726//PF06414//PF00910//PF08477//PF07728//PF13606//PF00158//PF00004//PF06309//PF07724//PF00448 ABC transporter//Ankyrin repeat//ATPase family associated with various cellular activities (AAA)//Zeta toxin//RNA helicase//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//Ankyrin repeat//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Torsin//AAA domain (Cdc48 subfamily)//SRP54-type protein, GTPase domain GO:0007264//GO:0006355//GO:0006614 small GTPase mediated signal transduction//regulation of transcription, DNA-templated//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0005525//GO:0016301//GO:0016887//GO:0005515//GO:0008134//GO:0005524//GO:0003723 RNA helicase activity//GTP binding//kinase activity//ATPase activity//protein binding//transcription factor binding//ATP binding//RNA binding GO:0005667 transcription factor complex KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases Cluster-8309.45734 BP_3 5.00 12.93 286 332375450 AEE62866.1 139 1.4e-06 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45736 BP_3 1540.01 52.93 1694 546671664 ERL83880.1 838 7.4e-87 hypothetical protein D910_01160 [Dendroctonus ponderosae]>gi|546671671|gb|ERL83885.1| hypothetical protein D910_01165 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P8Y1 518 3.9e-51 Calcyphosin-like protein OS=Mus musculus GN=Capsl PE=2 SV=4 PF13202//PF13833//PF00036//PF13405//PF13499 EF hand//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.45737 BP_3 387.41 4.60 4355 189237113 XP_971629.2 1209 1.8e-129 PREDICTED: xyloside xylosyltransferase 1 [Tribolium castaneum]>gi|270007231|gb|EFA03679.1| hypothetical protein TcasGA2_TC013781 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBI6 600 3.1e-60 Xyloside xylosyltransferase 1 OS=Homo sapiens GN=XXYLT1 PE=1 SV=1 PF13202//PF13499//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509//GO:0016757 calcium ion binding//transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.45738 BP_3 1229.38 50.94 1455 546671664 ERL83880.1 951 5.0e-100 hypothetical protein D910_01160 [Dendroctonus ponderosae]>gi|546671671|gb|ERL83885.1| hypothetical protein D910_01165 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P8Y1 574 1.1e-57 Calcyphosin-like protein OS=Mus musculus GN=Capsl PE=2 SV=4 PF13202//PF13499//PF13405//PF10591//PF13833//PF00036 EF hand//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.45739 BP_3 2.00 0.36 560 332375450 AEE62866.1 181 3.7e-11 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8WWF8 136 2.5e-07 Calcyphosin-like protein OS=Homo sapiens GN=CAPSL PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45742 BP_3 1121.16 8.00 7045 270013942 EFA10390.1 1611 7.2e-176 hypothetical protein TcasGA2_TC012621 [Tribolium castaneum] 642935672 XM_969594.3 364 0 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 11 (LOC663555), mRNA K03036 PSMD11, RPN6 26S proteasome regulatory subunit N6 http://www.genome.jp/dbget-bin/www_bget?ko:K03036 Q7KLV9 1341 6.0e-146 26S proteasome non-ATPase regulatory subunit 11 OS=Drosophila melanogaster GN=Rpn6 PE=1 SV=1 PF01399//PF05524//PF05823 PCI domain//PEP-utilising enzyme, N-terminal//Nematode fatty acid retinoid binding protein (Gp-FAR-1) GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.45744 BP_3 19.00 0.42 2489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45746 BP_3 9.00 1.03 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45747 BP_3 63.65 0.40 7963 91084687 XP_968830.1 2292 8.7e-255 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] 831284033 XM_012817767.1 98 1.20807e-40 PREDICTED: Clupea harengus myotubularin-related protein 3-like (LOC105891591), mRNA K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q13615 1397 2.2e-152 Myotubularin-related protein 3 OS=Homo sapiens GN=MTMR3 PE=1 SV=3 PF00782//PF01363//PF00400//PF07646//PF00102 Dual specificity phosphatase, catalytic domain//FYVE zinc finger//WD domain, G-beta repeat//Kelch motif//Protein-tyrosine phosphatase GO:0035335//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0046872//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//metal ion binding//protein tyrosine/serine/threonine phosphatase activity//protein binding -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.45749 BP_3 215.14 1.28 8386 478259801 ENN79629.1 3196 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.20252e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.7e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433//PF00443 Peptidase family M1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0008237//GO:0008270//GO:0036459 metallopeptidase activity//zinc ion binding//ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.4575 BP_3 1.00 0.47 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45752 BP_3 658.25 4.42 7462 478252915 ENN73299.1 1438 8.7e-156 hypothetical protein YQE_10063, partial [Dendroctonus ponderosae]>gi|546681594|gb|ERL91658.1| hypothetical protein D910_08986, partial [Dendroctonus ponderosae] -- -- -- -- -- K16526 AKAP10 A-kinase anchor protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16526 O88845 730 4.5e-75 A-kinase anchor protein 10, mitochondrial OS=Mus musculus GN=Akap10 PE=1 SV=3 PF00002//PF02101 7 transmembrane receptor (Secretin family)//Ocular albinism type 1 protein GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.45756 BP_3 1667.79 18.39 4663 642922405 XP_008193143.1 994 1.7e-104 PREDICTED: tetratricopeptide repeat protein 14 isoform X2 [Tribolium castaneum] 642922404 XM_008194921.1 225 1.77649e-111 PREDICTED: Tribolium castaneum tetratricopeptide repeat protein 14 (LOC663177), transcript variant X2, mRNA -- -- -- -- Q9VGU5 596 9.7e-60 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF01080//PF13181//PF11744//PF15741//PF05053//PF13174//PF13371//PF02724//PF09726//PF13374//PF00515//PF13176//PF10486//PF13414 Presenilin//Tetratricopeptide repeat//Aluminium activated malate transporter//Ligand-dependent nuclear receptor-interacting factor 1//Menin//Tetratricopeptide repeat//Tetratricopeptide repeat//CDC45-like protein//Transmembrane protein//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Phosphoinositide 3-kinase gamma adapter protein p101 subunit//TPR repeat GO:0006355//GO:0007165//GO:0015743//GO:0006270 regulation of transcription, DNA-templated//signal transduction//malate transport//DNA replication initiation GO:0046935//GO:0004190//GO:0042974//GO:0005515 1-phosphatidylinositol-3-kinase regulator activity//aspartic-type endopeptidase activity//retinoic acid receptor binding//protein binding GO:0005944//GO:0005634//GO:0016021//GO:0005667 phosphatidylinositol 3-kinase complex, class IB//nucleus//integral component of membrane//transcription factor complex -- -- Cluster-8309.45757 BP_3 2248.22 20.78 5506 642927190 XP_008195173.1 7885 0.0e+00 PREDICTED: DNA-directed RNA polymerase II subunit RPB1 [Tribolium castaneum]>gi|270010112|gb|EFA06560.1| hypothetical protein TcasGA2_TC009471 [Tribolium castaneum] 324120583 AB596930.1 1941 0 Lucidina biplagiata RPB1 mRNA for RNA polymerase II largest subunit, partial cds, isolate: E-19 K03006 RPB1, POLR2A DNA-directed RNA polymerase II subunit RPB1 http://www.genome.jp/dbget-bin/www_bget?ko:K03006 P04052 7075 0.0e+00 DNA-directed RNA polymerase II subunit RPB1 OS=Drosophila melanogaster GN=RpII215 PE=3 SV=4 PF04997//PF04992//PF05001//PF00623//PF04998//PF01381//PF04983//PF05000//PF04990 RNA polymerase Rpb1, domain 1//RNA polymerase Rpb1, domain 6//RNA polymerase Rpb1 C-terminal repeat//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 5//Helix-turn-helix//RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 7 GO:0006206//GO:0006351//GO:0006144//GO:0006366 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//transcription from RNA polymerase II promoter GO:0043565//GO:0003899//GO:0003677 sequence-specific DNA binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005665 nucleolus//DNA-directed RNA polymerase II, core complex KOG0260 RNA polymerase II, large subunit Cluster-8309.45762 BP_3 37.86 1.14 1899 642925895 XP_008190722.1 1323 4.8e-143 PREDICTED: uncharacterized protein LOC661054 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 705 9.0e-73 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45764 BP_3 23.86 0.37 3427 332375600 AEE62941.1 1189 3.0e-127 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8WWV3 323 3.2e-28 Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens GN=RTN4IP1 PE=1 SV=2 PF08240 Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process -- -- -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.45765 BP_3 599.57 2.67 11097 642918318 XP_008191457.1 7327 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 195492470 XM_002093969.1 257 6.90527e-129 Drosophila yakuba GE20438 (Dyak\GE20438), partial mRNA -- -- -- -- Q9VS29 6236 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF16656//PF00041//PF04120//PF13895//PF07749 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Low affinity iron permease//Immunoglobulin domain//Endoplasmic reticulum protein ERp29, C-terminal domain GO:0006771//GO:0055085//GO:0019497 riboflavin metabolic process//transmembrane transport//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0005783 endoplasmic reticulum -- -- Cluster-8309.45766 BP_3 4.80 0.36 931 642920332 XP_975626.2 404 8.6e-37 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17078//PF04048 SWI5-dependent HO expression protein 3//Sec8 exocyst complex component specific domain GO:0051028//GO:0006904//GO:0048309//GO:0015031 mRNA transport//vesicle docking involved in exocytosis//endoplasmic reticulum inheritance//protein transport -- -- GO:0000145 exocyst KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.45767 BP_3 404.58 6.67 3214 642919831 XP_008192086.1 788 8.8e-81 PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919833|ref|XP_008192087.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919835|ref|XP_973145.3| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919837|ref|XP_008192088.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919839|ref|XP_008192090.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919841|ref|XP_008192091.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|270006383|gb|EFA02831.1| sprouty [Tribolium castaneum] -- -- -- -- -- K17383 SPRY2 protein sprouty homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17383 O44783 484 6.5e-47 Protein sprouty OS=Drosophila melanogaster GN=sty PE=1 SV=2 PF05210 Sprouty protein (Spry) GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development -- -- GO:0016020 membrane -- -- Cluster-8309.45768 BP_3 1271.25 28.72 2425 91083579 XP_968212.1 2253 8.9e-251 PREDICTED: lysine--tRNA ligase isoform X2 [Tribolium castaneum]>gi|270007824|gb|EFA04272.1| hypothetical protein TcasGA2_TC014562 [Tribolium castaneum] 157106532 XM_001649316.1 196 1.21286e-95 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1893 2.0e-210 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF01409//PF00152//PF17121//PF01336//PF06667 tRNA synthetases class II core domain (F)//tRNA synthetases class II (D, K and N)//Zinc finger, C3HC4 type (RING finger)//OB-fold nucleic acid binding domain//Phage shock protein B GO:0006430//GO:0009271//GO:0009085//GO:0006418//GO:0006355//GO:0043039 lysyl-tRNA aminoacylation//phage shock//lysine biosynthetic process//tRNA aminoacylation for protein translation//regulation of transcription, DNA-templated//tRNA aminoacylation GO:0005524//GO:0000049//GO:0005515//GO:0004824//GO:0003676//GO:0000166//GO:0008270//GO:0004812 ATP binding//tRNA binding//protein binding//lysine-tRNA ligase activity//nucleic acid binding//nucleotide binding//zinc ion binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.45769 BP_3 2090.62 10.31 10065 546685894 ERL95319.1 1917 3.4e-211 hypothetical protein D910_12585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MSS1 506 5.7e-49 Protein lava lamp OS=Drosophila melanogaster GN=lva PE=1 SV=2 PF06463//PF11427 Molybdenum Cofactor Synthesis C//Tc3 transposase GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0003677//GO:0051539 DNA binding//4 iron, 4 sulfur cluster binding GO:0019008 molybdopterin synthase complex -- -- Cluster-8309.4577 BP_3 10.00 0.34 1716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45770 BP_3 315.32 1.93 8183 642931705 XP_008196694.1 4269 0.0e+00 PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum]>gi|642931707|ref|XP_008196695.1| PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum] -- -- -- -- -- K06640 ATR serine/threonine-protein kinase ATR http://www.genome.jp/dbget-bin/www_bget?ko:K06640 Q13535 2096 2.0e-233 Serine/threonine-protein kinase ATR OS=Homo sapiens GN=ATR PE=1 SV=3 PF08064//PF02259//PF00454//PF02260 UME (NUC010) domain//FAT domain//Phosphatidylinositol 3- and 4-kinase//FATC domain GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0004674//GO:0016773 protein binding//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG0890 Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination Cluster-8309.45772 BP_3 307.22 3.37 4686 642939323 XP_969087.2 928 7.5e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 5.75892e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.2e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01956//PF01588//PF02724 Integral membrane protein DUF106//Putative tRNA binding domain//CDC45-like protein GO:0006270 DNA replication initiation GO:0000049 tRNA binding GO:0016020 membrane KOG2241 tRNA-binding protein Cluster-8309.45773 BP_3 19.05 0.52 2074 642937972 XP_008199150.1 1964 2.5e-217 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X3 [Tribolium castaneum] 827549661 XM_012691461.1 35 3.26765e-06 PREDICTED: Bombyx mori ATP-binding cassette sub-family A member 1-like (LOC101740368), transcript variant X2, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 984 4.4e-105 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF13304 AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.45774 BP_3 126.49 1.13 5681 642937978 XP_008199153.1 5190 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 76 1.46073e-28 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 2907 0.0e+00 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF04310//PF03193//PF00005//PF13304//PF06414//PF11080//PF00448 MukB N-terminal//Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//Protein of unknown function (DUF2622)//SRP54-type protein, GTPase domain GO:0051252//GO:0030261//GO:0007059//GO:0006614 regulation of RNA metabolic process//chromosome condensation//chromosome segregation//SRP-dependent cotranslational protein targeting to membrane GO:0016301//GO:0016887//GO:0005525//GO:0004521//GO:0003924//GO:0003677//GO:0005524 kinase activity//ATPase activity//GTP binding//endoribonuclease activity//GTPase activity//DNA binding//ATP binding GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.45777 BP_3 423.18 2.90 7322 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 5.09347e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 1.7e-26 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF13895//PF13855//PF00560//PF03526 Immunoglobulin domain//Leucine rich repeat//Leucine Rich Repeat//Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643//GO:0005515 toxic substance binding//protein binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.45778 BP_3 601.22 9.66 3291 642929848 XP_008196000.1 3334 0.0e+00 PREDICTED: alanine--tRNA ligase, mitochondrial [Tribolium castaneum] 599384916 XM_007409341.1 64 3.94659e-22 Melampsora larici-populina 98AG31 hypothetical protein (MELLADRAFT_48072), partial mRNA K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VRJ1 1963 2.1e-218 Alanine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-ala-m PE=2 SV=1 PF07973//PF08718//PF01411 Threonyl and Alanyl tRNA synthetase second additional domain//Glycolipid transfer protein (GLTP)//tRNA synthetases class II (A) GO:0046836//GO:0006531//GO:0006419//GO:0043039//GO:0006522 glycolipid transport//aspartate metabolic process//alanyl-tRNA aminoacylation//tRNA aminoacylation//alanine metabolic process GO:0004813//GO:0005524//GO:0017089//GO:0016876//GO:0051861//GO:0000166 alanine-tRNA ligase activity//ATP binding//glycolipid transporter activity//ligase activity, forming aminoacyl-tRNA and related compounds//glycolipid binding//nucleotide binding GO:0005737 cytoplasm KOG0188 Alanyl-tRNA synthetase Cluster-8309.45779 BP_3 196.70 2.90 3565 270014029 EFA10477.1 699 2.0e-70 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 1.18967e-22 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- Q5R6A9 173 8.3e-11 TOX high mobility group box family member 4 OS=Pongo abelii GN=TOX4 PE=2 SV=2 PF03460//PF11770 Nitrite/Sulfite reductase ferredoxin-like half domain//GRB2-binding adapter (GAPT) GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.45780 BP_3 69.38 0.84 4270 91077926 XP_974115.1 1002 1.8e-105 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] 689542246 LL999048.1 56 1.43746e-17 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_scaffold0000001 -- -- -- -- Q9X248 335 1.6e-29 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN=fabG PE=3 SV=1 PF00106//PF01370//PF07684//PF05889//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NOTCH protein//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0007219//GO:0008152//GO:0007275//GO:0030154//GO:0055114 Notch signaling pathway//metabolic process//multicellular organismal development//cell differentiation//oxidation-reduction process GO:0050662//GO:0003824//GO:0016740//GO:0016491//GO:0000166 coenzyme binding//catalytic activity//transferase activity//oxidoreductase activity//nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.45786 BP_3 340.85 3.47 5032 642931023 XP_008196183.1 2071 2.3e-229 PREDICTED: probable ribonuclease ZC3H12B isoform X2 [Tribolium castaneum] 642931022 XM_008197961.1 302 3.01177e-154 PREDICTED: Tribolium castaneum probable ribonuclease ZC3H12B (LOC661984), transcript variant X2, mRNA K18668 ZC3H12, MCPIP ribonuclease ZC3H12 http://www.genome.jp/dbget-bin/www_bget?ko:K18668 Q5DTV4 843 2.4e-88 Probable ribonuclease ZC3H12C OS=Mus musculus GN=Zc3h12c PE=2 SV=2 PF07499//PF01769//PF05157//PF00642 RuvA, C-terminal domain//Divalent cation transporter//Type II secretion system (T2SS), protein E, N-terminal domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006810//GO:0006281//GO:0006310//GO:0006812 transport//DNA repair//DNA recombination//cation transport GO:0005524//GO:0009378//GO:0046872//GO:0008324 ATP binding//four-way junction helicase activity//metal ion binding//cation transmembrane transporter activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG3777 Uncharacterized conserved protein Cluster-8309.45787 BP_3 921.00 14.00 3462 546675262 ERL86498.1 3058 0.0e+00 hypothetical protein D910_03902 [Dendroctonus ponderosae] 572263546 XM_006609915.1 337 7.22095e-174 PREDICTED: Apis dorsata protein crooked neck-like (LOC102679096), mRNA K12869 CRN, CRNKL1, CLF1, SYF3 crooked neck http://www.genome.jp/dbget-bin/www_bget?ko:K12869 P17886 2735 6.7e-308 Protein crooked neck OS=Drosophila melanogaster GN=crn PE=2 SV=2 PF02184//PF13374//PF05843//PF13414//PF13174//PF06330 HAT (Half-A-TPR) repeat//Tetratricopeptide repeat//Suppressor of forked protein (Suf)//TPR repeat//Tetratricopeptide repeat//Trichodiene synthase (TRI5) GO:0016114//GO:0016106//GO:0006397//GO:0006396 terpenoid biosynthetic process//sesquiterpenoid biosynthetic process//mRNA processing//RNA processing GO:0005515//GO:0045482 protein binding//trichodiene synthase activity GO:0005634//GO:0005622 nucleus//intracellular KOG1915 Cell cycle control protein (crooked neck) Cluster-8309.45788 BP_3 308.71 3.37 4713 642931023 XP_008196183.1 2086 4.0e-231 PREDICTED: probable ribonuclease ZC3H12B isoform X2 [Tribolium castaneum] 642931022 XM_008197961.1 301 1.01406e-153 PREDICTED: Tribolium castaneum probable ribonuclease ZC3H12B (LOC661984), transcript variant X2, mRNA K18668 ZC3H12, MCPIP ribonuclease ZC3H12 http://www.genome.jp/dbget-bin/www_bget?ko:K18668 Q5DTV4 846 1.0e-88 Probable ribonuclease ZC3H12C OS=Mus musculus GN=Zc3h12c PE=2 SV=2 PF05157//PF07499//PF01769//PF00642 Type II secretion system (T2SS), protein E, N-terminal domain//RuvA, C-terminal domain//Divalent cation transporter//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006810//GO:0006281//GO:0006310//GO:0006812 transport//DNA repair//DNA recombination//cation transport GO:0005524//GO:0008324//GO:0009378//GO:0046872 ATP binding//cation transmembrane transporter activity//four-way junction helicase activity//metal ion binding GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG3777 Uncharacterized conserved protein Cluster-8309.45789 BP_3 471.47 7.64 3267 91078940 XP_973987.1 1536 1.6e-167 PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|642916209|ref|XP_008190931.1| PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|270003691|gb|EFA00139.1| hypothetical protein TcasGA2_TC002960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWP6 582 2.8e-58 Motile sperm domain-containing protein 2 OS=Mus musculus GN=Mospd2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-8309.4579 BP_3 1.00 0.36 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45791 BP_3 533.79 5.39 5064 478255001 ENN75234.1 3133 0.0e+00 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1964 2.5e-218 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF01926//PF13304//PF00664//PF00437//PF06414//PF01637//PF03193//PF00005//PF01580 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Type II/IV secretion system protein//Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//FtsK/SpoIIIE family GO:0055085//GO:0006810 transmembrane transport//transport GO:0003677//GO:0005524//GO:0003924//GO:0016301//GO:0016887//GO:0000166//GO:0005525//GO:0042626 DNA binding//ATP binding//GTPase activity//kinase activity//ATPase activity//nucleotide binding//GTP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.45792 BP_3 32.15 0.49 3435 546678547 ERL89136.1 1910 7.4e-211 hypothetical protein D910_06512, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1189 1.2e-128 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF01443//PF01926//PF13304//PF08477//PF00437//PF01637//PF06414//PF02367//PF00005//PF03193//PF04670//PF01580//PF04548//PF01348 ABC transporter transmembrane region//Viral (Superfamily 1) RNA helicase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase//Type II/IV secretion system protein//Archaeal ATPase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//FtsK/SpoIIIE family//AIG1 family//Type II intron maturase GO:0006810//GO:0055085//GO:0006397//GO:0007264//GO:0002949 transport//transmembrane transport//mRNA processing//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0005524//GO:0003677//GO:0042626//GO:0000166//GO:0005525//GO:0016301//GO:0016887 GTPase activity//ATP binding//DNA binding//ATPase activity, coupled to transmembrane movement of substances//nucleotide binding//GTP binding//kinase activity//ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.45796 BP_3 60.86 0.56 5489 478255001 ENN75234.1 2239 8.4e-249 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1265 3.0e-137 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03041//PF01637//PF06414//PF00005//PF03193//PF00437//PF00664//PF01926//PF13304 lef-2//Archaeal ATPase//Zeta toxin//ABC transporter//Protein of unknown function, DUF258//Type II/IV secretion system protein//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006810//GO:0019083//GO:0055085 transport//viral transcription//transmembrane transport GO:0042626//GO:0016887//GO:0016301//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.45797 BP_3 669.00 10.80 3277 189235137 XP_001807432.1 2668 9.0e-299 PREDICTED: probable RNA-binding protein 19 [Tribolium castaneum]>gi|270003801|gb|EFA00249.1| hypothetical protein TcasGA2_TC003078 [Tribolium castaneum] -- -- -- -- -- K14787 MRD1, RBM19 multiple RNA-binding domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14787 Q8R3C6 1416 5.6e-155 Probable RNA-binding protein 19 OS=Mus musculus GN=Rbm19 PE=1 SV=1 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif -- -- GO:0003676//GO:1901363//GO:0003723//GO:0097159 nucleic acid binding//heterocyclic compound binding//RNA binding//organic cyclic compound binding -- -- KOG0110 RNA-binding protein (RRM superfamily) Cluster-8309.45799 BP_3 598.01 5.34 5689 642935331 XP_008197971.1 2924 0.0e+00 PREDICTED: regulator of G-protein signaling 7 isoform X2 [Tribolium castaneum] 642935330 XM_008199749.1 953 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC656292), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q80ZD1 950 1.1e-100 Regulator of G-protein signaling 9 OS=Tamias striatus PE=1 SV=1 PF00631//PF00424//PF00610 GGL domain//REV protein (anti-repression trans-activator protein)//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0006355//GO:0007186//GO:0035556//GO:0007165 regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway//intracellular signal transduction//signal transduction GO:0004871//GO:0003700 signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667//GO:0005834 host cell nucleus//transcription factor complex//heterotrimeric G-protein complex KOG3589 G protein signaling regulators Cluster-8309.45800 BP_3 27.74 0.42 3484 91085219 XP_972532.1 1550 4.2e-169 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009084|gb|EFA05532.1| hypothetical protein TcasGA2_TC015719 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 577 1.2e-57 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF05199 GMC oxidoreductase//GMC oxidoreductase GO:0006066//GO:0006563//GO:0055114//GO:0006544//GO:0006566 alcohol metabolic process//L-serine metabolic process//oxidation-reduction process//glycine metabolic process//threonine metabolic process GO:0016614//GO:0008812//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.45802 BP_3 32.35 0.34 4829 91080259 XP_973356.1 2365 1.8e-263 PREDICTED: TBC1 domain family member 23 [Tribolium castaneum]>gi|270005620|gb|EFA02068.1| hypothetical protein TcasGA2_TC007702 [Tribolium castaneum] 641791443 XM_005305637.2 106 2.6098e-45 PREDICTED: Chrysemys picta bellii chaperonin containing TCP1, subunit 4 (delta) (CCT4), mRNA K09496 CCT4 T-complex protein 1 subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K09496 Q9NB32 2088 9.9e-233 T-complex protein 1 subunit delta OS=Ochlerotatus triseriatus PE=2 SV=1 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding GO:0005622 intracellular KOG0358 Chaperonin complex component, TCP-1 delta subunit (CCT4) Cluster-8309.45803 BP_3 354.93 5.42 3446 91076338 XP_971007.1 2127 5.1e-236 PREDICTED: protein TAPT1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VED0 1430 1.4e-156 Protein TAPT1 homolog OS=Drosophila melanogaster GN=CG7218 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2490 Predicted membrane protein Cluster-8309.45804 BP_3 264.00 6.29 2315 642928539 XP_008195366.1 627 3.0e-62 PREDICTED: trypsin-1-like [Tribolium castaneum]>gi|270011007|gb|EFA07455.1| serine protease P94 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 435 2.2e-41 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0003824 serine-type endopeptidase activity//catalytic activity -- -- -- -- Cluster-8309.45805 BP_3 323.03 3.53 4707 270004078 EFA00526.1 412 5.1e-37 hypothetical protein TcasGA2_TC003391 [Tribolium castaneum] 662204498 XM_008477405.1 35 7.48328e-06 PREDICTED: Diaphorina citri uncharacterized LOC103512635 (LOC103512635), mRNA -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity -- -- -- -- Cluster-8309.45806 BP_3 1013.55 3.20 15538 642934439 XP_008197663.1 5595 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 642934440 XM_008199442.1 135 6.38333e-61 PREDICTED: Tribolium castaneum nucleosome-remodeling factor subunit NURF301 (LOC100141790), transcript variant X3, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1598 2.1e-175 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00155//PF02178//PF13639//PF12125//PF00439//PF16866//PF00628//PF00202 Aminotransferase class I and II//AT hook motif//Ring finger domain//D domain of beta-TrCP//Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III GO:0009058 biosynthetic process GO:0003677//GO:0008270//GO:0005515//GO:0008483//GO:0030170//GO:0046983 DNA binding//zinc ion binding//protein binding//transaminase activity//pyridoxal phosphate binding//protein dimerization activity -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.45808 BP_3 10.84 0.40 1611 478255226 ENN75455.1 523 2.4e-50 hypothetical protein YQE_08005, partial [Dendroctonus ponderosae] 242013552 XM_002427424.1 53 2.49017e-16 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K11728 BPTF, E(bx) nucleosome-remodeling factor subunit BPTF http://www.genome.jp/dbget-bin/www_bget?ko:K11728 Q9W0T1 367 1.2e-33 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45809 BP_3 246.16 19.25 908 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00957//PF06209 Synaptobrevin//Cofactor of BRCA1 (COBRA1) GO:0045892//GO:0016192 negative regulation of transcription, DNA-templated//vesicle-mediated transport -- -- GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.45810 BP_3 54.49 1.67 1863 828177651 AKK25148.1 438 2.0e-40 chemosensory protein 4 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 251 3.9e-20 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01299//PF00957//PF06209 Lysosome-associated membrane glycoprotein (Lamp)//Synaptobrevin//Cofactor of BRCA1 (COBRA1) GO:0016192//GO:0045892 vesicle-mediated transport//negative regulation of transcription, DNA-templated -- -- GO:0016020//GO:0016021//GO:0005634 membrane//integral component of membrane//nucleus -- -- Cluster-8309.45812 BP_3 80.69 0.99 4204 642922624 XP_008193254.1 3594 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] 642922625 XM_008195033.1 226 4.44933e-112 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07291 Methylamine utilisation protein MauE GO:0030416 methylamine metabolic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45813 BP_3 155.00 2.29 3548 642922624 XP_008193254.1 3525 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45814 BP_3 404.10 2.62 7727 642937296 XP_008198775.1 2919 0.0e+00 PREDICTED: uncharacterized protein LOC658848 isoform X3 [Tribolium castaneum] 642937295 XM_008200553.1 210 6.4344e-103 PREDICTED: Tribolium castaneum uncharacterized LOC658848 (LOC658848), transcript variant X3, mRNA -- -- -- -- Q70EL1 831 9.0e-87 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Homo sapiens GN=USP54 PE=1 SV=4 PF00126//PF09663 Bacterial regulatory helix-turn-helix protein, lysR family//Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) GO:0006807//GO:0006355 nitrogen compound metabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0016812 transcription factor activity, sequence-specific DNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0005667 transcription factor complex KOG1887 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.45815 BP_3 9.00 0.46 1243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45817 BP_3 330.77 3.14 5371 642928768 XP_008195553.1 4200 0.0e+00 PREDICTED: ATPase, class II, type 9B isoform X2 [Tribolium castaneum] 462389179 APGK01019264.1 69 1.07478e-24 Dendroctonus ponderosae Seq01019274, whole genome shotgun sequence K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 O43861 2973 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Homo sapiens GN=ATP9B PE=2 SV=4 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0210 P-type ATPase Cluster-8309.45818 BP_3 120.16 1.21 5096 322794211 EFZ17393.1 1470 1.2e-159 hypothetical protein SINV_02519, partial [Solenopsis invicta] 572309672 XM_006620560.1 86 3.61484e-34 PREDICTED: Apis dorsata cell division cycle and apoptosis regulator protein 1-like (LOC102677857), transcript variant X2, mRNA -- -- -- -- Q8IX12 823 5.0e-86 Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens GN=CCAR1 PE=1 SV=2 PF06495//PF03153//PF01247 Fruit fly transformer protein//Transcription factor IIA, alpha/beta subunit//Ribosomal protein L35Ae GO:0042254//GO:0006367//GO:0046660//GO:0006412//GO:0006397 ribosome biogenesis//transcription initiation from RNA polymerase II promoter//female sex differentiation//translation//mRNA processing GO:0003735 structural constituent of ribosome GO:0005622//GO:0005672//GO:0005840//GO:0005634 intracellular//transcription factor TFIIA complex//ribosome//nucleus KOG4246 Predicted DNA-binding protein, contains SAP domain Cluster-8309.45821 BP_3 157.14 2.64 3162 189240526 XP_972038.2 1592 5.1e-174 PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933395|ref|XP_008197398.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933397|ref|XP_008197400.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933399|ref|XP_008197401.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933402|ref|XP_008197402.1| PREDICTED: epsin-1 [Tribolium castaneum] 462340791 APGK01036278.1 94 7.97538e-39 Dendroctonus ponderosae Seq01036288, whole genome shotgun sequence K12471 EPN epsin http://www.genome.jp/dbget-bin/www_bget?ko:K12471 Q9Z1Z3 828 8.2e-87 Epsin-2 OS=Rattus norvegicus GN=Epn2 PE=1 SV=1 PF07651//PF09298//PF00790 ANTH domain//Fumarylacetoacetase N-terminal//VHS domain GO:0006886//GO:0006570//GO:0042207//GO:0009072 intracellular protein transport//tyrosine metabolic process//styrene catabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0005543 fumarylacetoacetase activity//phospholipid binding -- -- KOG2056 Equilibrative nucleoside transporter protein Cluster-8309.45822 BP_3 756.82 15.54 2639 189240526 XP_972038.2 1592 4.3e-174 PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933395|ref|XP_008197398.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933397|ref|XP_008197400.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933399|ref|XP_008197401.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933402|ref|XP_008197402.1| PREDICTED: epsin-1 [Tribolium castaneum] 462340791 APGK01036278.1 94 6.64569e-39 Dendroctonus ponderosae Seq01036288, whole genome shotgun sequence K12471 EPN epsin http://www.genome.jp/dbget-bin/www_bget?ko:K12471 Q9Z1Z3 828 6.9e-87 Epsin-2 OS=Rattus norvegicus GN=Epn2 PE=1 SV=1 PF07651//PF00790//PF09298 ANTH domain//VHS domain//Fumarylacetoacetase N-terminal GO:0006886//GO:0006570//GO:0042207//GO:0009072 intracellular protein transport//tyrosine metabolic process//styrene catabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0005543 fumarylacetoacetase activity//phospholipid binding -- -- KOG2056 Equilibrative nucleoside transporter protein Cluster-8309.45823 BP_3 105.76 1.68 3324 189240526 XP_972038.2 1592 5.4e-174 PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933395|ref|XP_008197398.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933397|ref|XP_008197400.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933399|ref|XP_008197401.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933402|ref|XP_008197402.1| PREDICTED: epsin-1 [Tribolium castaneum] 462340791 APGK01036278.1 94 8.38869e-39 Dendroctonus ponderosae Seq01036288, whole genome shotgun sequence K12471 EPN epsin http://www.genome.jp/dbget-bin/www_bget?ko:K12471 Q9Z1Z3 828 8.6e-87 Epsin-2 OS=Rattus norvegicus GN=Epn2 PE=1 SV=1 PF07651//PF09298//PF00790 ANTH domain//Fumarylacetoacetase N-terminal//VHS domain GO:0009072//GO:0042207//GO:0006886//GO:0006570 aromatic amino acid family metabolic process//styrene catabolic process//intracellular protein transport//tyrosine metabolic process GO:0005543//GO:0004334 phospholipid binding//fumarylacetoacetase activity -- -- KOG2056 Equilibrative nucleoside transporter protein Cluster-8309.45825 BP_3 870.77 11.13 4062 270009986 EFA06434.1 1589 1.5e-173 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.9e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF01544//PF02653//PF03359 CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component//Guanylate-kinase-associated protein (GKAP) protein GO:0055085//GO:0023052//GO:0030001//GO:0006810 transmembrane transport//signaling//metal ion transport//transport GO:0046873//GO:0005215 metal ion transmembrane transporter activity//transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.45826 BP_3 250.95 6.27 2221 546673801 ERL85345.1 1439 2.0e-156 hypothetical protein D910_02765 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7SXW3 744 3.2e-77 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.45828 BP_3 25.59 0.82 1803 270015218 EFA11666.1 360 2.1e-31 hypothetical protein TcasGA2_TC008530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW3 162 7.9e-10 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF08163//PF13855 NUC194 domain//Leucine rich repeat GO:0009069//GO:0016310//GO:0006303 serine family amino acid metabolic process//phosphorylation//double-strand break repair via nonhomologous end joining GO:0005515//GO:0004677//GO:0005524//GO:0003677 protein binding//DNA-dependent protein kinase activity//ATP binding//DNA binding GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0619 FOG: Leucine rich repeat Cluster-8309.45833 BP_3 2.00 6.24 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45834 BP_3 206.93 1.44 7242 91075968 XP_969381.1 1380 4.5e-149 PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|642910393|ref|XP_008190714.1| PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|270014619|gb|EFA11067.1| hypothetical protein TcasGA2_TC004663 [Tribolium castaneum] -- -- -- -- -- K03522 fixB, etfA electron transfer flavoprotein alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03522 P13803 751 1.6e-77 Electron transfer flavoprotein subunit alpha, mitochondrial OS=Rattus norvegicus GN=Etfa PE=1 SV=4 PF07224//PF16987//PF03403//PF00326//PF07819//PF04083//PF12740//PF15453//PF02230//PF06821 Chlorophyllase//KIX domain//Platelet-activating factor acetylhydrolase, isoform II//Prolyl oligopeptidase family//PGAP1-like protein//Partial alpha/beta-hydrolase lipase region//Chlorophyllase enzyme//Protein incorporated later into Tight Junctions//Phospholipase/Carboxylesterase//Serine hydrolase GO:0015996//GO:0006505//GO:0006886//GO:0006355//GO:0046486//GO:0006629//GO:0015994//GO:0016042//GO:0006508 chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport//regulation of transcription, DNA-templated//glycerolipid metabolic process//lipid metabolic process//chlorophyll metabolic process//lipid catabolic process//proteolysis GO:0016787//GO:0003847//GO:0003712//GO:0008236//GO:0016788//GO:0047746 hydrolase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//transcription cofactor activity//serine-type peptidase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity GO:0005923//GO:0008247//GO:0005667 bicellular tight junction//1-alkyl-2-acetylglycerophosphocholine esterase complex//transcription factor complex KOG3954 Electron transfer flavoprotein, alpha subunit Cluster-8309.45837 BP_3 72.02 0.69 5339 642928974 XP_008195641.1 904 5.2e-94 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum]>gi|642928976|ref|XP_008195642.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ULP2 147 1.3e-07 Aftiphilin OS=Homo sapiens GN=AFTPH PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45838 BP_3 71.83 0.58 6290 546677600 ERL88405.1 5090 0.0e+00 hypothetical protein D910_05791 [Dendroctonus ponderosae] -- -- -- -- -- K17601 WDR81 WD repeat-containing protein 81 http://www.genome.jp/dbget-bin/www_bget?ko:K17601 D4A929 968 9.5e-103 WD repeat-containing protein 81 OS=Rattus norvegicus GN=Wdr81 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.45840 BP_3 15.89 0.40 2187 478263151 ENN81544.1 923 1.3e-96 hypothetical protein YQE_02073, partial [Dendroctonus ponderosae] -- -- -- -- -- K18166 FOXRED1 FAD-dependent oxidoreductase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18166 Q6DCP1 543 6.3e-54 FAD-dependent oxidoreductase domain-containing protein 1 OS=Xenopus laevis GN=foxred1 PE=2 SV=1 PF00070//PF02558//PF01210//PF03435//PF01266//PF05834//PF02254//PF07992//PF01494 Pyridine nucleotide-disulphide oxidoreductase//Ketopantoate reductase PanE/ApbA//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//Lycopene cyclase protein//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain GO:0055114//GO:0016117//GO:0006813//GO:0046168//GO:0015940 oxidation-reduction process//carotenoid biosynthetic process//potassium ion transport//glycerol-3-phosphate catabolic process//pantothenate biosynthetic process GO:0008677//GO:0016491//GO:0016616//GO:0051287//GO:0071949//GO:0016705 2-dehydropantoate 2-reductase activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//FAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG2853 Possible oxidoreductase Cluster-8309.45844 BP_3 76.70 1.07 3733 759001854 AJP08639.1 1844 3.6e-203 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 436 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1619 1.8e-178 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF03242//PF06293//PF00069 Protein tyrosine kinase//Late embryogenesis abundant protein//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006950//GO:0006468 response to stress//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.45846 BP_3 73.10 0.52 7049 91091256 XP_968850.1 1918 1.8e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.7e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF01398//PF04117//PF00180 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Mpv17 / PMP22 family//Isocitrate/isopropylmalate dehydrogenase GO:0006099//GO:0055114//GO:0006749//GO:0006102//GO:0019643 tricarboxylic acid cycle//oxidation-reduction process//glutathione metabolic process//isocitrate metabolic process//reductive tricarboxylic acid cycle GO:0000287//GO:0004450//GO:0005515//GO:0051287//GO:0016616 magnesium ion binding//isocitrate dehydrogenase (NADP+) activity//protein binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.45847 BP_3 41.27 1.18 1977 755545949 XP_011242903.1 916 7.8e-96 PREDICTED: zinc finger protein 431-like, partial [Mus musculus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 875 1.8e-92 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF05864//PF13912//PF16622//PF07776//PF00096//PF13465 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.45849 BP_3 47.62 0.46 5286 675371881 KFM64783.1 284 4.0e-22 Hypothetical protein in type-1 retrotransposable element R1DM, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P16425 223 2.0e-16 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF13949 ALIX V-shaped domain binding to HIV -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45850 BP_3 42.48 0.31 6881 675371505 KFM64407.1 682 3.7e-68 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P16425 223 2.5e-16 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF13949//PF00484 ALIX V-shaped domain binding to HIV//Carbonic anhydrase GO:0006807//GO:0006730 nitrogen compound metabolic process//one-carbon metabolic process GO:0005515//GO:0004089//GO:0008270 protein binding//carbonate dehydratase activity//zinc ion binding -- -- -- -- Cluster-8309.45851 BP_3 14.60 2.49 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45852 BP_3 260.00 24.23 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03920//PF00170//PF13851//PF06005//PF04111//PF02183//PF00225//PF09728//PF07926//PF04136 Groucho/TLE N-terminal Q-rich domain//bZIP transcription factor//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//Autophagy protein Apg6//Homeobox associated leucine zipper//Kinesin motor domain//Myosin-like coiled-coil protein//TPR/MLP1/MLP2-like protein//Sec34-like family GO:0000917//GO:0043093//GO:0048870//GO:0006606//GO:0006355//GO:0007017//GO:0007018//GO:0006886//GO:0006914 barrier septum assembly//FtsZ-dependent cytokinesis//cell motility//protein import into nucleus//regulation of transcription, DNA-templated//microtubule-based process//microtubule-based movement//intracellular protein transport//autophagy GO:0008017//GO:0003777//GO:0005515//GO:0019905//GO:0043565//GO:0003700//GO:0005524 microtubule binding//microtubule motor activity//protein binding//syntaxin binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//ATP binding GO:0016020//GO:0005667//GO:0005874//GO:0005801//GO:0005737//GO:0031514//GO:0045298 membrane//transcription factor complex//microtubule//cis-Golgi network//cytoplasm//motile cilium//tubulin complex -- -- Cluster-8309.45853 BP_3 39.89 0.67 3173 642919263 XP_008191800.1 1439 2.8e-156 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8BGM5 922 1.0e-97 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.45855 BP_3 97.95 2.88 1929 642918534 XP_008191512.1 171 1.9e-09 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45856 BP_3 709.50 27.62 1530 665803886 XP_008550059.1 162 1.6e-08 PREDICTED: uncharacterized protein LOC103572990 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.45857 BP_3 38.77 1.19 1856 731463707 XP_003407411.2 579 8.8e-57 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100675838 [Loxodonta africana] 642923856 XM_008195686.1 161 2.6431e-76 PREDICTED: Tribolium castaneum uncharacterized LOC663851 (LOC663851), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A1YF12 559 7.5e-56 Zinc finger protein 16 OS=Gorilla gorilla gorilla GN=ZNF16 PE=3 SV=1 PF13912//PF07776//PF16622//PF13465//PF00096//PF01155 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0008270//GO:0046872//GO:0016151 zinc ion binding//metal ion binding//nickel cation binding GO:0005634 nucleus -- -- Cluster-8309.45858 BP_3 49.05 3.87 902 642935862 XP_008198202.1 691 4.4e-70 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q920N5 202 9.1e-15 Peroxisomal targeting signal 1 receptor OS=Cricetulus griseus GN=PEX5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45859 BP_3 24.74 0.32 4032 641650582 XP_008189789.1 1152 6.9e-123 PREDICTED: uncharacterized protein LOC103311826 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225//PF06449 DDE superfamily endonuclease//helix-turn-helix, Psq domain//Mitochondrial domain of unknown function (DUF1082) -- -- GO:0003677//GO:0003676//GO:0016820 DNA binding//nucleic acid binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016021//GO:0005739 integral component of membrane//mitochondrion -- -- Cluster-8309.45862 BP_3 141.00 30.83 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45863 BP_3 1903.56 8.99 10501 642913929 XP_008201218.1 1980 1.7e-218 PREDICTED: headcase protein [Tribolium castaneum] 642913928 XM_008202996.1 693 0 PREDICTED: Tribolium castaneum headcase protein (LOC664275), mRNA -- -- -- -- Q9N2M8 849 1.0e-88 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 PF02701//PF10403 Dof domain, zinc finger//Rad4 beta-hairpin domain 1 GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3816 Cell differentiation regulator of the Headcase family Cluster-8309.45864 BP_3 47.27 0.36 6697 646719715 KDR21733.1 2722 1.0e-304 Importin-7 [Zootermopsis nevadensis] 558207907 XM_006132981.1 93 6.10938e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2243 1.5e-250 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.45865 BP_3 451.28 3.64 6268 642929348 XP_008195797.1 4436 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1650 7.9e-182 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF00787//PF00498//PF00225 PX domain//FHA domain//Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0035091//GO:0005515//GO:0003777//GO:0008017 ATP binding//phosphatidylinositol binding//protein binding//microtubule motor activity//microtubule binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG0245 Kinesin-like protein Cluster-8309.45866 BP_3 15.97 0.83 1221 642912944 XP_008201318.1 552 7.8e-54 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22922 382 1.6e-35 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45869 BP_3 105.86 2.68 2197 642933610 XP_008197493.1 1933 1.0e-213 PREDICTED: stress-activated protein kinase JNK isoform X2 [Tribolium castaneum] 170029895 XM_001842775.1 532 0 Culex quinquefasciatus jnk, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1693 2.8e-187 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF03708//PF07714//PF01429//PF00069//PF06293 Avian retrovirus envelope protein, gp85//Protein tyrosine kinase//Methyl-CpG binding domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0005524//GO:0003677//GO:0016773//GO:0004672 ATP binding//DNA binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0005634//GO:0019031//GO:0016020 nucleus//viral envelope//membrane -- -- Cluster-8309.45871 BP_3 1492.00 16.69 4600 546684887 ERL94469.1 2704 8.5e-303 hypothetical protein D910_11746 [Dendroctonus ponderosae] -- -- -- -- -- K10866 RAD50 DNA repair protein RAD50 http://www.genome.jp/dbget-bin/www_bget?ko:K10866 Q9W252 1533 2.1e-168 DNA repair protein RAD50 OS=Drosophila melanogaster GN=rad50 PE=2 SV=4 PF13304//PF16331//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//TolA binding protein trimerisation//ABC transporter GO:0070206 protein trimerization GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- KOG0962 DNA repair protein RAD50, ABC-type ATPase/SMC superfamily Cluster-8309.45872 BP_3 581.05 5.23 5651 189235813 XP_971989.2 2629 5.2e-294 PREDICTED: probable cytosolic oligopeptidase A [Tribolium castaneum] 689005257 LL516414.1 39 5.37581e-08 Onchocerca ochengi genome assembly O_ochengi_Ngaoundere ,scaffold OOCN_contig0000027 K01409 KAE1, tsaD, QRI7 N6-L-threonylcarbamoyladenine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01409 Q7SYR1 1314 6.5e-143 Probable tRNA N6-adenosine threonylcarbamoyltransferase OS=Xenopus laevis GN=osgep PE=2 SV=1 PF02543//PF01432 Carbamoyltransferase N-terminus//Peptidase family M3 GO:0006508//GO:0009058 proteolysis//biosynthetic process GO:0004222//GO:0003824 metalloendopeptidase activity//catalytic activity -- -- KOG2708 Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold) Cluster-8309.45873 BP_3 178.40 0.55 16050 766923154 XP_011506186.1 4186 0.0e+00 PREDICTED: voltage-dependent calcium channel type A subunit alpha-1 [Ceratosolen solmsi marchali] 259906454 NM_001165911.1 1031 0 Tribolium castaneum cacophony A (Cac), mRNA >gnl|BL_ORD_ID|7385018 Tribolium castaneum cacophony A (CAC) mRNA, complete cds K04344 CACNA1A voltage-dependent calcium channel P/Q type alpha-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04344 P91645 2341 1.5e-261 Voltage-dependent calcium channel type A subunit alpha-1 OS=Drosophila melanogaster GN=cac PE=2 SV=3 PF01635//PF00520//PF00230//PF02561//PF14138//PF13405//PF00036 Coronavirus M matrix/glycoprotein//Ion transport protein//Major intrinsic protein//Flagellar protein FliS//Cytochrome c oxidase assembly protein COX16//EF-hand domain//EF hand GO:0006811//GO:0006810//GO:0019058//GO:0055085 ion transport//transport//viral life cycle//transmembrane transport GO:0005216//GO:0005509//GO:0005215 ion channel activity//calcium ion binding//transporter activity GO:0031966//GO:0016020//GO:0009288 mitochondrial membrane//membrane//bacterial-type flagellum KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.45874 BP_3 4.00 1.67 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45877 BP_3 406.22 6.30 3399 642919831 XP_008192086.1 788 9.3e-81 PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919833|ref|XP_008192087.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919835|ref|XP_973145.3| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919837|ref|XP_008192088.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919839|ref|XP_008192090.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919841|ref|XP_008192091.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|270006383|gb|EFA02831.1| sprouty [Tribolium castaneum] -- -- -- -- -- K17383 SPRY2 protein sprouty homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17383 O44783 484 6.8e-47 Protein sprouty OS=Drosophila melanogaster GN=sty PE=1 SV=2 PF05210 Sprouty protein (Spry) GO:0007275//GO:0009966 multicellular organismal development//regulation of signal transduction -- -- GO:0016020 membrane -- -- Cluster-8309.45878 BP_3 124.04 1.49 4295 91090558 XP_971487.1 1781 8.5e-196 PREDICTED: translation initiation factor eIF-2B subunit gamma [Tribolium castaneum]>gi|270013887|gb|EFA10335.1| hypothetical protein TcasGA2_TC012553 [Tribolium castaneum] 828217611 XM_002154671.3 60 8.64104e-20 PREDICTED: Hydra vulgaris transcription elongation factor 1 homolog (LOC100207595), mRNA K03241 EIF2B3 translation initiation factor eIF-2B subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03241 A5PJI7 711 4.1e-73 Translation initiation factor eIF-2B subunit gamma OS=Bos taurus GN=EIF2B3 PE=2 SV=1 PF00483//PF07959//PF01128 Nucleotidyl transferase//L-fucokinase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299//GO:0009058//GO:0006694 isoprenoid biosynthetic process//biosynthetic process//steroid biosynthetic process GO:0050518//GO:0016779//GO:0016772 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1) Cluster-8309.4588 BP_3 3349.12 27.20 6226 546681025 ERL91190.1 1905 5.1e-210 hypothetical protein D910_08529 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0S8 265 3.1e-21 Leukocyte elastase inhibitor OS=Xenopus tropicalis GN=serpinb1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45882 BP_3 547.34 3.75 7335 642915664 XP_008190703.1 5589 0.0e+00 PREDICTED: nephrin isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZS7 1262 9.0e-137 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF13895//PF00041//PF05434 Immunoglobulin domain//Fibronectin type III domain//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules Cluster-8309.45885 BP_3 9.91 6.23 365 -- -- -- -- -- 462329210 APGK01040426.1 36 1.48024e-07 Dendroctonus ponderosae Seq01040436, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.45886 BP_3 1.31 0.54 406 -- -- -- -- -- 462329210 APGK01040426.1 36 1.66304e-07 Dendroctonus ponderosae Seq01040436, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.45888 BP_3 5404.07 64.28 4344 646696935 KDR08899.1 1285 2.8e-138 Beta-amyloid-like protein, partial [Zootermopsis nevadensis] 462380259 APGK01022394.1 40 1.14676e-08 Dendroctonus ponderosae Seq01022404, whole genome shotgun sequence K04520 APP amyloid beta A4 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04520 P14599 928 2.9e-98 Beta-amyloid-like protein OS=Drosophila melanogaster GN=Appl PE=1 SV=2 PF12924//PF02177 Copper-binding of amyloid precursor, CuBD//Amyloid A4 N-terminal heparin-binding -- -- GO:0046914//GO:0008201 transition metal ion binding//heparin binding -- -- KOG3540 Beta amyloid precursor protein Cluster-8309.45895 BP_3 81.21 0.66 6179 478249960 ENN70467.1 2128 7.0e-236 hypothetical protein YQE_12970, partial [Dendroctonus ponderosae] -- -- -- -- -- K10777 LIG4, DNL4 DNA ligase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10777 Q90YB1 1021 6.7e-109 DNA ligase 4 OS=Gallus gallus GN=LIG4 PE=2 SV=2 PF04675//PF06814//PF04679//PF01068//PF11411 DNA ligase N terminus//Lung seven transmembrane receptor//ATP dependent DNA ligase C terminal region//ATP dependent DNA ligase domain//DNA ligase IV GO:0006281//GO:0006260//GO:0006310 DNA repair//DNA replication//DNA recombination GO:0003910//GO:0003677//GO:0005524 DNA ligase (ATP) activity//DNA binding//ATP binding GO:0016021 integral component of membrane KOG0966 ATP-dependent DNA ligase IV Cluster-8309.45898 BP_3 26.53 0.73 2040 270014308 EFA10756.1 897 1.3e-93 cytochrome P450-like protein [Tribolium castaneum] 826490357 XM_012684512.1 42 4.12719e-10 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105838744), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 582 1.8e-58 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.4590 BP_3 106.10 0.81 6610 546681025 ERL91190.1 1077 5.6e-114 hypothetical protein D910_08529 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O73860 164 1.7e-09 Ovalbumin OS=Meleagris gallopavo GN=SERPINB14 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45900 BP_3 737.28 4.72 7824 642914403 XP_008201481.1 2794 0.0e+00 PREDICTED: TELO2-interacting protein 1 homolog [Tribolium castaneum] 780665329 XM_011695591.1 124 4.17915e-55 PREDICTED: Wasmannia auropunctata uncharacterized LOC105453540 (LOC105453540), mRNA -- -- -- -- Q3ZCX4 649 1.2e-65 Zinc finger protein 568 OS=Homo sapiens GN=ZNF568 PE=2 SV=2 PF13465//PF08880//PF00096//PF02985//PF08064 Zinc-finger double domain//QLQ//Zinc finger, C2H2 type//HEAT repeat//UME (NUC010) domain GO:0016310//GO:0009069//GO:0006355 phosphorylation//serine family amino acid metabolic process//regulation of transcription, DNA-templated GO:0005515//GO:0005524//GO:0046872//GO:0004674 protein binding//ATP binding//metal ion binding//protein serine/threonine kinase activity GO:0005634 nucleus -- -- Cluster-8309.45902 BP_3 15.89 0.95 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45903 BP_3 1222.75 9.22 6683 642928510 XP_008193821.1 3443 0.0e+00 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X2 [Tribolium castaneum] 755894366 XM_011297040.1 39 6.36089e-08 PREDICTED: Musca domestica multiple C2 and transmembrane domain-containing protein 1 (LOC101898395), transcript variant X1, mRNA -- -- -- -- Q6DN14 1246 5.9e-135 Multiple C2 and transmembrane domain-containing protein 1 OS=Homo sapiens GN=MCTP1 PE=2 SV=2 PF00606//PF02542//PF00168 Herpesvirus Glycoprotein B//YgbB family//C2 domain GO:0016114 terpenoid biosynthetic process GO:0005515//GO:0008685 protein binding//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity GO:0016020 membrane KOG1030 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.45906 BP_3 920.85 11.18 4261 642923667 XP_008193834.1 4119 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15439 2437 3.0e-273 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00931//PF02367//PF06414//PF00006//PF03205//PF03193//PF03266//PF00005//PF13304//PF01926//PF01443//PF00664//PF08477 NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ATP synthase alpha/beta family, nucleotide-binding domain//Molybdopterin guanine dinucleotide synthesis protein B//Protein of unknown function, DUF258//NTPase//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Viral (Superfamily 1) RNA helicase//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0006777//GO:0002949//GO:0006810//GO:0055085 small GTPase mediated signal transduction//Mo-molybdopterin cofactor biosynthetic process//tRNA threonylcarbamoyladenosine modification//transport//transmembrane transport GO:0042626//GO:0016887//GO:0016301//GO:0005525//GO:0003924//GO:0043531//GO:0098519//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTP binding//GTPase activity//ADP binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.45907 BP_3 86.39 0.97 4581 91087437 XP_975683.1 1563 1.7e-170 PREDICTED: calbindin-32 isoform X2 [Tribolium castaneum]>gi|270009492|gb|EFA05940.1| hypothetical protein TcasGA2_TC008758 [Tribolium castaneum] 768416565 XM_011550577.1 347 2.64467e-179 PREDICTED: Plutella xylostella calbindin-32 (LOC105380953), mRNA -- -- -- -- P41044 1359 3.2e-148 Calbindin-32 OS=Drosophila melanogaster GN=Cbp53E PE=2 SV=1 PF13202//PF12763//PF00036//PF13833//PF13405//PF13499 EF hand//Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.45908 BP_3 86.84 1.20 3789 270009834 EFA06282.1 2409 1.1e-268 hypothetical protein TcasGA2_TC009148 [Tribolium castaneum] -- -- -- -- -- K12600 SKI3, TTC37 superkiller protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12600 Q6PGP7 940 1.0e-99 Tetratricopeptide repeat protein 37 OS=Homo sapiens GN=TTC37 PE=1 SV=1 PF13174//PF13181//PF12513//PF13414//PF13176//PF00515//PF13374//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Mitochondrial degradasome RNA helicase subunit C terminal//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0016817//GO:0005515 hydrolase activity, acting on acid anhydrides//protein binding -- -- KOG1127 TPR repeat-containing protein Cluster-8309.4591 BP_3 134.00 4.17 1839 478256216 ENN76410.1 208 9.1e-14 hypothetical protein YQE_07071, partial [Dendroctonus ponderosae]>gi|546684462|gb|ERL94101.1| hypothetical protein D910_11383 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45910 BP_3 187.15 2.55 3826 546683595 ERL93390.1 1233 2.6e-132 hypothetical protein D910_10682 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45911 BP_3 2.31 0.51 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45912 BP_3 72.27 0.88 4230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05737 Collagen binding domain -- -- GO:0005518 collagen binding GO:0005581 collagen trimer -- -- Cluster-8309.45913 BP_3 462.00 6.57 3679 546670890 ERL83460.1 943 1.1e-98 hypothetical protein D910_00452 [Dendroctonus ponderosae]>gi|546677255|gb|ERL88124.1| hypothetical protein D910_05512 [Dendroctonus ponderosae]>gi|546678640|gb|ERL89222.1| hypothetical protein D910_06596 [Dendroctonus ponderosae] -- -- -- -- -- K07928 RAB40 Ras-related protein Rab-40 http://www.genome.jp/dbget-bin/www_bget?ko:K07928 Q8VHQ4 748 1.8e-77 Ras-related protein Rab-40C OS=Mus musculus GN=Rab40c PE=2 SV=1 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.45915 BP_3 115.54 0.72 8040 242008211 XP_002424904.1 2464 1.0e-274 zinc finger protein, putative [Pediculus humanus corporis]>gi|212508484|gb|EEB12166.1| zinc finger protein, putative [Pediculus humanus corporis] 817192597 XM_012416318.1 430 0 PREDICTED: Orussus abietinus zinc finger protein 665-like (LOC105695064), transcript variant X6, mRNA -- -- -- -- P51523 1365 1.1e-148 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00830//PF13465//PF00096//PF06467//PF14764//PF13912//PF02892 Ribosomal L28 family//Zinc-finger double domain//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//AP-5 complex subunit, vesicle trafficking//C2H2-type zinc finger//BED zinc finger GO:0042254 ribosome biogenesis GO:0003677//GO:0005488//GO:0008270//GO:0003735//GO:0046872 DNA binding//binding//zinc ion binding//structural constituent of ribosome//metal ion binding GO:0005840//GO:0044599 ribosome//AP-5 adaptor complex -- -- Cluster-8309.45916 BP_3 142.12 0.90 7929 242008211 XP_002424904.1 2464 9.9e-275 zinc finger protein, putative [Pediculus humanus corporis]>gi|212508484|gb|EEB12166.1| zinc finger protein, putative [Pediculus humanus corporis] 817192597 XM_012416318.1 430 0 PREDICTED: Orussus abietinus zinc finger protein 665-like (LOC105695064), transcript variant X6, mRNA -- -- -- -- P51523 1365 1.1e-148 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF14764//PF13912//PF06467 Zinc finger, C2H2 type//Zinc-finger double domain//AP-5 complex subunit, vesicle trafficking//C2H2-type zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0005488//GO:0008270 metal ion binding//binding//zinc ion binding GO:0044599 AP-5 adaptor complex -- -- Cluster-8309.45917 BP_3 83.00 1.96 2333 270016078 EFA12526.1 1195 4.1e-128 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 793 6.9e-83 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF00665//PF10371 Integrase core domain//Domain of unknown function GO:0055114//GO:0015074 oxidation-reduction process//DNA integration GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors -- -- -- -- Cluster-8309.45920 BP_3 19.42 0.46 2319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45921 BP_3 74.68 0.61 6205 242013664 XP_002427522.1 1953 1.4e-215 adenosylhomocysteinase, putative [Pediculus humanus corporis]>gi|212511924|gb|EEB14784.1| adenosylhomocysteinase, putative [Pediculus humanus corporis] 821118450 XM_004463226.2 166 1.4873e-78 PREDICTED: Dasypus novemcinctus adenosylhomocysteinase-like 2 (AHCYL2), transcript variant X6, mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q96HN2 1757 3.0e-194 Adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1 PF13241//PF07992//PF05221//PF07851//PF02826//PF02882//PF02254 Putative NAD(P)-binding//Pyridine nucleotide-disulphide oxidoreductase//S-adenosyl-L-homocysteine hydrolase//TMPIT-like protein//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//TrkA-N domain GO:0006730//GO:0006779//GO:0006555//GO:0055114//GO:0019354//GO:0046487//GO:0009396//GO:0006813 one-carbon metabolic process//porphyrin-containing compound biosynthetic process//methionine metabolic process//oxidation-reduction process//siroheme biosynthetic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//potassium ion transport GO:0043115//GO:0003824//GO:0004488//GO:0016491//GO:0051287//GO:0004013 precorrin-2 dehydrogenase activity//catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity//NAD binding//adenosylhomocysteinase activity GO:0016021 integral component of membrane KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.45922 BP_3 251.42 3.23 4043 546678692 ERL89260.1 3267 0.0e+00 hypothetical protein D910_06633, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1260 8.5e-137 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.45923 BP_3 100.15 2.58 2160 571330962 AHF27413.1 1329 1.1e-143 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A5LGM7 437 1.2e-41 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.45928 BP_3 2639.29 34.51 3978 642913546 XP_008201056.1 1646 3.5e-180 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 645 1.7e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.45929 BP_3 278.44 3.53 4098 642924614 XP_008194364.1 2671 5.1e-299 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 5.7e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.45930 BP_3 99.00 1.00 5061 642917976 XP_008198967.1 3341 0.0e+00 PREDICTED: follistatin-related protein 5-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BFR2 1162 2.5e-125 Follistatin-related protein 5 OS=Mus musculus GN=Fstl5 PE=2 SV=1 PF10591//PF13833//PF13405//PF13499//PF00050//PF00036//PF07648//PF13895//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Kazal-type serine protease inhibitor domain//EF hand//Kazal-type serine protease inhibitor domain//Immunoglobulin domain//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.45936 BP_3 42.36 4.49 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45937 BP_3 206.39 4.26 2627 642910319 XP_969877.2 2468 1.1e-275 PREDICTED: uridine-cytidine kinase-like 1 [Tribolium castaneum] 602627952 XM_007420856.1 35 4.15387e-06 PREDICTED: Python bivittatus uridine-cytidine kinase-like 1-like (LOC103062425), mRNA K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q91YL3 1454 1.8e-159 Uridine-cytidine kinase-like 1 OS=Mus musculus GN=Uckl1 PE=2 SV=1 PF02224//PF00485//PF01583//PF01121//PF06414//PF03205//PF07931 Cytidylate kinase//Phosphoribulokinase / Uridine kinase family//Adenylylsulphate kinase//Dephospho-CoA kinase//Zeta toxin//Molybdopterin guanine dinucleotide synthesis protein B//Chloramphenicol phosphotransferase-like protein GO:0015940//GO:0008152//GO:0000103//GO:0006139//GO:0006144//GO:0006777//GO:0006206//GO:0015937 pantothenate biosynthetic process//metabolic process//sulfate assimilation//nucleobase-containing compound metabolic process//purine nucleobase metabolic process//Mo-molybdopterin cofactor biosynthetic process//pyrimidine nucleobase metabolic process//coenzyme A biosynthetic process GO:0016740//GO:0005524//GO:0004020//GO:0004127//GO:0016301//GO:0005525//GO:0004140 transferase activity//ATP binding//adenylylsulfate kinase activity//cytidylate kinase activity//kinase activity//GTP binding//dephospho-CoA kinase activity -- -- KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.45938 BP_3 23.78 0.43 2978 91093871 XP_967859.1 963 4.2e-101 PREDICTED: OTU domain-containing protein 5-A [Tribolium castaneum]>gi|270014527|gb|EFA10975.1| hypothetical protein TcasGA2_TC004141 [Tribolium castaneum] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q640H3 388 8.1e-36 OTU domain-containing protein 5-B OS=Xenopus laevis GN=otud5-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.45939 BP_3 259.18 5.55 2541 91087799 XP_967345.1 3115 0.0e+00 PREDICTED: threonine--tRNA ligase, cytoplasmic isoform X2 [Tribolium castaneum] 572269851 XM_006612875.1 387 0 PREDICTED: Apis dorsata threonine--tRNA ligase, cytoplasmic-like (LOC102672191), transcript variant X2, mRNA K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q3ZBV8 2707 8.7e-305 Threonine--tRNA ligase, cytoplasmic OS=Bos taurus GN=TARS PE=2 SV=1 PF00587//PF07973 tRNA synthetase class II core domain (G, H, P, S and T)//Threonyl and Alanyl tRNA synthetase second additional domain GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0000166//GO:0005524//GO:0004812//GO:0016876 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity//ligase activity, forming aminoacyl-tRNA and related compounds -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.45941 BP_3 203.11 4.29 2575 817061558 XP_012252386.1 254 5.9e-19 PREDICTED: collagen alpha-3(IX) chain-like [Athalia rosae] -- -- -- -- -- K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 Q07092 197 9.9e-14 Collagen alpha-1(XVI) chain OS=Homo sapiens GN=COL16A1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.45942 BP_3 922.00 10.88 4378 332374982 AEE62632.1 800 4.9e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13800 CMPK1, UMPK UMP-CMP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13800 Q29561 644 2.5e-65 UMP-CMP kinase OS=Sus scrofa GN=CMPK1 PE=1 SV=1 PF00910//PF06414 RNA helicase//Zeta toxin -- -- GO:0003724//GO:0016301//GO:0005524//GO:0003723 RNA helicase activity//kinase activity//ATP binding//RNA binding -- -- KOG3079 Uridylate kinase/adenylate kinase Cluster-8309.45946 BP_3 310.87 10.97 1658 751457144 XP_011183174.1 1497 2.8e-163 PREDICTED: protein will die slowly [Bactrocera cucurbitae] 585715269 XM_006825240.1 164 5.06328e-78 PREDICTED: Saccoglossus kowalevskii protein will die slowly-like (LOC100375790), mRNA K14963 WDR5, SWD3, CPS30 COMPASS component SWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K14963 Q9V3J8 1450 3.2e-159 Protein will die slowly OS=Drosophila melanogaster GN=wds PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.45948 BP_3 384.00 9.84 2172 642912880 XP_971262.2 1272 4.5e-137 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45949 BP_3 49.31 2.75 1155 270012481 EFA08929.1 901 2.5e-94 hypothetical protein TcasGA2_TC006636 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 576 5.0e-58 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.45950 BP_3 128.13 7.35 1132 478257458 ENN77614.1 1202 3.1e-129 hypothetical protein YQE_05909, partial [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 767 3.5e-80 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.45952 BP_3 220.32 16.21 947 642937660 XP_008198889.1 727 3.1e-74 PREDICTED: tetraspanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17353 TSPAN18 tetraspanin-18 http://www.genome.jp/dbget-bin/www_bget?ko:K17353 Q96SJ8 233 2.4e-18 Tetraspanin-18 OS=Homo sapiens GN=TSPAN18 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.45958 BP_3 8.00 80.67 243 642918497 XP_972472.3 148 1.1e-07 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X1 [Tribolium castaneum]>gi|270004628|gb|EFA01076.1| hypothetical protein TcasGA2_TC003997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45959 BP_3 16.50 6.66 410 642918497 XP_972472.3 134 7.7e-06 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X1 [Tribolium castaneum]>gi|270004628|gb|EFA01076.1| hypothetical protein TcasGA2_TC003997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45960 BP_3 436.25 5.38 4203 642918499 XP_008191499.1 263 8.7e-20 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P298 133 4.3e-06 HIG1 domain family member 1B OS=Homo sapiens GN=HIGD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45962 BP_3 143.75 0.94 7624 642918499 XP_008191499.1 263 1.6e-19 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P298 133 7.7e-06 HIG1 domain family member 1B OS=Homo sapiens GN=HIGD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45964 BP_3 613.77 10.30 3163 189239405 XP_001813943.1 2912 0.0e+00 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] 637379439 XM_008125298.1 41 2.31435e-09 PREDICTED: Anolis carolinensis nuclear export mediator factor NEMF-like (LOC103282578), mRNA -- -- -- -- O60524 1933 6.1e-215 Nuclear export mediator factor NEMF OS=Homo sapiens GN=NEMF PE=1 SV=4 PF08052 PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process -- -- -- -- KOG2030 Predicted RNA-binding protein Cluster-8309.45965 BP_3 3225.01 16.86 9510 91084029 XP_966465.1 4108 0.0e+00 PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|642924795|ref|XP_008194044.1| PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270006700|gb|EFA03148.1| hypothetical protein TcasGA2_TC013061 [Tribolium castaneum] 440199242 JQ783618.1 203 6.17089e-99 Schreckensteinia sp. Sktn ala-tRNA synthetase mRNA, partial cds K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VLM8 3510 0.0e+00 Alanine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-ala PE=2 SV=1 PF00005//PF01399//PF00400//PF03193//PF01018//PF01411//PF02272//PF00493//PF01580//PF00071//PF01926//PF07973//PF01343//PF00025//PF02421 ABC transporter//PCI domain//WD domain, G-beta repeat//Protein of unknown function, DUF258//GTP1/OBG//tRNA synthetases class II (A)//DHHA1 domain//MCM2/3/5 family//FtsK/SpoIIIE family//Ras family//50S ribosome-binding GTPase//Threonyl and Alanyl tRNA synthetase second additional domain//Peptidase family S49//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0043039//GO:0007264//GO:0006413//GO:0006508//GO:0006522//GO:0006446//GO:0006531//GO:0006419//GO:0015684//GO:0006260 tRNA aminoacylation//small GTPase mediated signal transduction//translational initiation//proteolysis//alanine metabolic process//regulation of translational initiation//aspartate metabolic process//alanyl-tRNA aminoacylation//ferrous iron transport//DNA replication GO:0003676//GO:0005525//GO:0005515//GO:0004813//GO:0003677//GO:0015093//GO:0016876//GO:0008233//GO:0016887//GO:0000166//GO:0003924//GO:0003743//GO:0005524 nucleic acid binding//GTP binding//protein binding//alanine-tRNA ligase activity//DNA binding//ferrous iron transmembrane transporter activity//ligase activity, forming aminoacyl-tRNA and related compounds//peptidase activity//ATPase activity//nucleotide binding//GTPase activity//translation initiation factor activity//ATP binding GO:0005737//GO:0005840//GO:0016021 cytoplasm//ribosome//integral component of membrane KOG0188 Alanyl-tRNA synthetase Cluster-8309.45966 BP_3 53.65 1.43 2103 642915190 XP_008190511.1 1436 4.2e-156 PREDICTED: protein phosphatase 1 regulatory subunit 12B-like isoform X1 [Tribolium castaneum] 242023035 XM_002431897.1 50 1.52025e-14 Pediculus humanus corporis protein phosphatase 1 regulatory subunit 12B, putative, mRNA K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q90623 953 1.8e-101 Protein phosphatase 1 regulatory subunit 12A OS=Gallus gallus GN=PPP1R12A PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.45967 BP_3 8.12 0.83 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03896 Translocon-associated protein (TRAP), alpha subunit -- -- -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.45969 BP_3 2.00 1.32 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45970 BP_3 16.00 0.81 1239 861605932 KMQ84424.1 265 1.5e-20 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45972 BP_3 466.66 5.35 4495 642912808 XP_008201260.1 1904 4.8e-210 PREDICTED: neurogenic protein mastermind-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21519 206 1.6e-14 Neurogenic protein mastermind OS=Drosophila melanogaster GN=mam PE=2 SV=2 PF09596 MamL-1 domain GO:0007219//GO:0045944 Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter GO:0003713 transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex -- -- Cluster-8309.45974 BP_3 164.95 1.24 6708 642940098 XP_008192969.1 1320 3.8e-142 PREDICTED: excitatory amino acid transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 Q10901 652 4.5e-66 Excitatory amino acid transporter OS=Caenorhabditis elegans GN=glt-1 PE=1 SV=2 PF00375//PF01585 Sodium:dicarboxylate symporter family//G-patch domain GO:0006812//GO:0006835//GO:0006820 cation transport//dicarboxylic acid transport//anion transport GO:0003676//GO:0017153 nucleic acid binding//sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.45975 BP_3 319.52 2.42 6661 642940098 XP_008192969.1 1251 3.8e-134 PREDICTED: excitatory amino acid transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K05612 SLC1A1, EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05612 Q10901 602 2.8e-60 Excitatory amino acid transporter OS=Caenorhabditis elegans GN=glt-1 PE=1 SV=2 PF00375//PF01585 Sodium:dicarboxylate symporter family//G-patch domain GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153//GO:0003676 sodium:dicarboxylate symporter activity//nucleic acid binding GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.45977 BP_3 847.21 12.29 3614 642939887 XP_008200200.1 3339 0.0e+00 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12616 EDC4 enhancer of mRNA-decapping protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12616 Q1LUT1 643 2.7e-65 Enhancer of mRNA-decapping protein 4 OS=Danio rerio GN=edc4 PE=3 SV=1 PF08236//PF06152//PF01442//PF03127 SRI (Set2 Rpb1 interacting) domain//Phage minor capsid protein 2//Apolipoprotein A1/A4/E domain//GAT domain GO:0006869//GO:0006886//GO:0034968//GO:0042157//GO:0006554//GO:0006355//GO:0006479 lipid transport//intracellular protein transport//histone lysine methylation//lipoprotein metabolic process//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005198//GO:0008289//GO:0018024 structural molecule activity//lipid binding//histone-lysine N-methyltransferase activity GO:0019028//GO:0005576//GO:0005622//GO:0005694 viral capsid//extracellular region//intracellular//chromosome KOG1916 Nuclear protein, contains WD40 repeats Cluster-8309.45978 BP_3 17.00 21.61 318 -- -- -- -- -- 225543475 NM_001145913.1 55 3.48335e-18 Tribolium castaneum ventral vein lacking (Vvl), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45979 BP_3 438.89 4.06 5508 546675238 ERL86474.1 1956 5.5e-216 hypothetical protein D910_03880 [Dendroctonus ponderosae] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q54G06 923 1.4e-97 Xaa-Pro aminopeptidase 1 OS=Dictyostelium discoideum GN=xpnpep1 PE=3 SV=1 PF01321//PF01398//PF04961//PF02723//PF10278 Creatinase/Prolidase N-terminal domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//Non-structural protein NS3/Small envelope protein E//Mediator of RNA pol II transcription subunit 19 GO:0006357//GO:0044237 regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0001104//GO:0016787//GO:0005515 catalytic activity//RNA polymerase II transcription cofactor activity//hydrolase activity//protein binding GO:0016020//GO:0016592 membrane//mediator complex KOG2413 Xaa-Pro aminopeptidase Cluster-8309.45983 BP_3 77.21 0.61 6344 91087271 XP_975540.1 2035 4.4e-225 PREDICTED: TLD domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJX5 624 7.5e-63 TLD domain-containing protein 1 OS=Gallus gallus GN=TLDC1 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2557 Uncharacterized conserved protein, contains TLDc domain Cluster-8309.45984 BP_3 14.00 0.47 1732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135 Nucleolar RNA-binding protein, Nop10p family GO:0001522//GO:0042254 pseudouridine synthesis//ribosome biogenesis GO:0030515 snoRNA binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.45985 BP_3 34.57 0.31 5696 642917693 XP_008191332.1 2197 6.5e-244 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q9Y4K4 1110 3.0e-119 Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens GN=MAP4K5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45990 BP_3 888.88 21.52 2283 642929118 XP_008195696.1 834 2.9e-86 PREDICTED: uncharacterized protein LOC100142378 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42891 537 3.3e-53 Endothelin-converting enzyme 1 OS=Bos taurus GN=ECE1 PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.45993 BP_3 787.02 7.41 5409 546684088 ERL93807.1 1248 6.8e-134 hypothetical protein D910_11093 [Dendroctonus ponderosae] -- -- -- -- -- K06627 CCNA cyclin A http://www.genome.jp/dbget-bin/www_bget?ko:K06627 P14785 768 1.3e-79 G2/mitotic-specific cyclin-A OS=Drosophila melanogaster GN=CycA PE=1 SV=3 PF05461//PF04108//PF02984//PF00210//PF08336 Apolipoprotein L//Autophagy protein Apg17//Cyclin, C-terminal domain//Ferritin-like domain//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0006560//GO:0006869//GO:0006914//GO:0042157//GO:0018401//GO:0006525//GO:0006879//GO:0055114 proline metabolic process//lipid transport//autophagy//lipoprotein metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process//cellular iron ion homeostasis//oxidation-reduction process GO:0016702//GO:0008289//GO:0004656//GO:0008199 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//lipid binding//procollagen-proline 4-dioxygenase activity//ferric iron binding GO:0005783//GO:0005634//GO:0005576 endoplasmic reticulum//nucleus//extracellular region KOG0654 G2/Mitotic-specific cyclin A Cluster-8309.45997 BP_3 246.06 3.90 3334 642929686 XP_008195936.1 1180 3.2e-126 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] 462360465 APGK01029384.1 79 1.83429e-30 Dendroctonus ponderosae Seq01029394, whole genome shotgun sequence K06064 HAIRLESS hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06064 Q02308 257 1.4e-20 Protein hairless OS=Drosophila melanogaster GN=H PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.460 BP_3 23.61 1.65 981 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46000 BP_3 42.64 0.65 3467 332374952 AEE62617.1 516 3.3e-49 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CW42 275 1.2e-22 Mitochondrial amidoxime-reducing component 1 OS=Mus musculus GN=Marc1 PE=1 SV=2 PF03473 MOSC domain -- -- GO:0003824//GO:0030151//GO:0030170 catalytic activity//molybdenum ion binding//pyridoxal phosphate binding -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.46001 BP_3 2212.25 32.76 3547 649572315 NP_001280527.1 2820 0.0e+00 lethal(2) giant larvae protein homolog 1 [Tribolium castaneum]>gi|642930673|ref|XP_008199983.1| PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X1 [Tribolium castaneum]>gi|270012677|gb|EFA09125.1| hypothetical protein TcasGA2_TC015986 [Tribolium castaneum]>gi|625293659|gb|AHY24027.1| lethal giant larvae [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 Q08470 1450 6.9e-159 Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura GN=l(2)gl PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.46005 BP_3 426.41 5.06 4352 642930648 XP_008199209.1 3390 0.0e+00 PREDICTED: gamma-tubulin complex component 6 [Tribolium castaneum] -- -- -- -- -- K16573 TUBGCP6, GCP6 gamma-tubulin complex component 6 http://www.genome.jp/dbget-bin/www_bget?ko:K16573 Q96RT7 575 2.5e-57 Gamma-tubulin complex component 6 OS=Homo sapiens GN=TUBGCP6 PE=1 SV=3 PF04130 Spc97 / Spc98 family GO:0000226//GO:0090063 microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0000922//GO:0005815 spindle pole//microtubule organizing center KOG2001 Gamma-tubulin complex, DGRIP84/SPC97 component Cluster-8309.46007 BP_3 60.09 1.48 2246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46008 BP_3 268.09 2.10 6432 642921412 XP_008192854.1 1114 2.8e-118 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.47121e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 791 3.3e-82 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF05648//PF00937 Peroxisomal biogenesis factor 11 (PEX11)//Coronavirus nucleocapsid protein GO:0016559 peroxisome fission -- -- GO:0019013//GO:0005779 viral nucleocapsid//integral component of peroxisomal membrane -- -- Cluster-8309.46009 BP_3 113.91 1.41 4191 642913916 XP_008201212.1 3081 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X1 [Tribolium castaneum] 755870656 XM_005181954.2 137 1.32363e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 P51812 2107 5.4e-235 Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1 PF00433//PF07714//PF06293//PF00069 Protein kinase C terminal domain//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.46014 BP_3 14596.26 326.27 2448 21218350 AAM44045.1 2540 4.7e-284 arylphorin-like hexamerin [Apriona germari] 21218349 AF509880.1 489 0 Apriona germari arylphorin-like hexamerin mRNA, complete cds -- -- -- -- Q17127 1167 3.1e-126 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 PF12464 Maltose acetyltransferase GO:0042967 acyl-carrier-protein biosynthetic process GO:0016407 acetyltransferase activity -- -- -- -- Cluster-8309.46015 BP_3 47.27 1.00 2577 642929247 XP_008195752.1 173 1.5e-09 PREDICTED: uncharacterized protein LOC103313669 [Tribolium castaneum]>gi|270010484|gb|EFA06932.1| hypothetical protein TcasGA2_TC009882 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09788 Transmembrane protein 55A GO:0046856 phosphatidylinositol dephosphorylation GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity -- -- -- -- Cluster-8309.46016 BP_3 15.15 0.64 1439 642935463 XP_008198020.1 1481 1.7e-161 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X1 [Tribolium castaneum] 820850190 XM_012487292.1 50 1.03212e-14 PREDICTED: Apis florea constitutive coactivator of PPAR-gamma-like protein 1 homolog (LOC100866531), mRNA -- -- -- -- Q6DEZ2 566 9.0e-57 Constitutive coactivator of PPAR-gamma-like protein 1 homolog OS=Xenopus tropicalis GN=fam120a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46018 BP_3 209.09 2.20 4881 189236382 XP_969620.2 2293 4.1e-255 PREDICTED: serine/threonine-protein kinase PAK mbt [Tribolium castaneum] 158287954 XM_309828.4 261 1.80829e-131 Anopheles gambiae str. PEST AGAP010874-PA (AgaP_AGAP010874) mRNA, complete cds K05736 PAK7 p21-activated kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05736 Q9VXE5 1526 1.5e-167 Serine/threonine-protein kinase PAK mbt OS=Drosophila melanogaster GN=mbt PE=1 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.46019 BP_3 346.91 3.85 4633 189236382 XP_969620.2 2293 3.9e-255 PREDICTED: serine/threonine-protein kinase PAK mbt [Tribolium castaneum] 158287954 XM_309828.4 261 1.71573e-131 Anopheles gambiae str. PEST AGAP010874-PA (AgaP_AGAP010874) mRNA, complete cds K05736 PAK7 p21-activated kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05736 Q9VXE5 1526 1.4e-167 Serine/threonine-protein kinase PAK mbt OS=Drosophila melanogaster GN=mbt PE=1 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.46020 BP_3 1017.00 27.52 2073 270010572 EFA07020.1 714 2.2e-72 hypothetical protein TcasGA2_TC009991 [Tribolium castaneum] 642929657 XM_970383.2 189 8.05182e-92 PREDICTED: Tribolium castaneum AP-2 complex subunit sigma (LOC664376), mRNA K11827 AP2S1 AP-2 complex subunit sigma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11827 P62744 692 3.2e-71 AP-2 complex subunit sigma OS=Rattus norvegicus GN=Ap2s1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0935 Clathrin adaptor complex, small subunit Cluster-8309.46021 BP_3 682.25 11.71 3100 91079410 XP_967066.1 1352 3.4e-146 PREDICTED: nudC domain-containing protein 1 [Tribolium castaneum]>gi|270003473|gb|EEZ99920.1| hypothetical protein TcasGA2_TC002712 [Tribolium castaneum] -- -- -- -- -- K07071 K07071 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K07071 Q6PIP5 687 1.8e-70 NudC domain-containing protein 1 OS=Mus musculus GN=Nudcd1 PE=2 SV=2 PF01370//PF02827//PF00070 NAD dependent epimerase/dehydratase family//cAMP-dependent protein kinase inhibitor//Pyridine nucleotide-disulphide oxidoreductase GO:0045859//GO:0006469//GO:0055114 regulation of protein kinase activity//negative regulation of protein kinase activity//oxidation-reduction process GO:0016491//GO:0050662//GO:0003824//GO:0004862 oxidoreductase activity//coenzyme binding//catalytic activity//cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex KOG4379 Uncharacterized conserved protein (tumor antigen CML66 in humans) Cluster-8309.46022 BP_3 8.00 0.72 830 3907620 AAC78681.1 346 4.1e-30 actin 1 [Penaeus monodon] 795401007 XM_012087502.1 131 5.49239e-60 PREDICTED: Cercocebus atys actin, beta (ACTB), mRNA K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 P90689 341 6.4e-31 Actin OS=Brugia malayi PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.46023 BP_3 404.80 10.08 2227 91086839 XP_974133.1 262 6.0e-20 PREDICTED: transmembrane protein 14C [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQN6 158 2.8e-09 Transmembrane protein 14C OS=Mus musculus GN=Tmem14c PE=1 SV=1 PF03647 Transmembrane proteins 14C -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.46025 BP_3 266.00 6.17 2369 91093509 XP_969295.1 1113 1.3e-118 PREDICTED: ras-related protein Rab-39B [Tribolium castaneum]>gi|270002676|gb|EEZ99123.1| hypothetical protein TcasGA2_TC005229 [Tribolium castaneum] -- -- -- -- -- K07925 RAB39B Ras-related protein Rab-39B http://www.genome.jp/dbget-bin/www_bget?ko:K07925 Q8BHD0 613 5.2e-62 Ras-related protein Rab-39A OS=Mus musculus GN=Rab39a PE=1 SV=1 PF03193//PF08477//PF01926//PF00025//PF04670//PF00071 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.46029 BP_3 1017.12 7.61 6735 270016510 EFA12956.1 3014 0.0e+00 pumilio [Tribolium castaneum] 642939433 XM_008202167.1 706 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.7e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806 CPL (NUC119) domain//Pumilio-family RNA binding repeat -- -- GO:0003723 RNA binding -- -- KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.46030 BP_3 60.11 0.40 7567 642939434 XP_008200389.1 4121 0.0e+00 PREDICTED: pumilio homolog 2 isoform X2 [Tribolium castaneum] 642939433 XM_008202167.1 727 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF00806//PF08144 Pumilio-family RNA binding repeat//CPL (NUC119) domain -- -- GO:0003723 RNA binding -- -- KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.46033 BP_3 96.00 10.80 720 795016637 XP_011858564.1 169 1.2e-09 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01429 Methyl-CpG binding domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.46034 BP_3 112.99 1.22 4754 642912121 XP_008200815.1 1300 5.6e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1R3 469 5.3e-45 StAR-related lipid transfer protein 7, mitochondrial OS=Mus musculus GN=Stard7 PE=2 SV=2 PF12831//PF01593//PF09452//PF07992//PF01494//PF00899//PF07664//PF00070//PF01852//PF01134//PF00965//PF01266 FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//ESCRT-I subunit Mvb12//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//ThiF family//Ferrous iron transport protein B C terminus//Pyridine nucleotide-disulphide oxidoreductase//START domain//Glucose inhibited division protein A//Tissue inhibitor of metalloproteinase//FAD dependent oxidoreductase GO:0032509//GO:0055114//GO:0008033//GO:0015684 endosome transport via multivesicular body sorting pathway//oxidation-reduction process//tRNA processing//ferrous iron transport GO:0016491//GO:0015093//GO:0008289//GO:0043130//GO:0071949//GO:0008191//GO:0008641//GO:0050660 oxidoreductase activity//ferrous iron transmembrane transporter activity//lipid binding//ubiquitin binding//FAD binding//metalloendopeptidase inhibitor activity//small protein activating enzyme activity//flavin adenine dinucleotide binding GO:0016021//GO:0000813 integral component of membrane//ESCRT I complex -- -- Cluster-8309.46035 BP_3 90.60 8.25 821 642937344 XP_008198797.1 914 5.5e-96 PREDICTED: centaurin-gamma-1A [Tribolium castaneum] 701339117 XM_009982980.1 84 7.27745e-34 PREDICTED: Tauraco erythrolophus arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like (LOC104376406), partial mRNA K12491 AGAP1_3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12491 Q9NGC3 790 5.4e-83 Centaurin-gamma-1A OS=Drosophila melanogaster GN=CenG1A PE=2 SV=2 PF00071//PF08477 Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains) Cluster-8309.46036 BP_3 218.75 1.22 8901 642935083 XP_008197877.1 3809 0.0e+00 PREDICTED: calmodulin-binding transcription activator 2-like isoform X3 [Tribolium castaneum] 642935084 XM_008199656.1 481 0 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- Q9Y6Y1 651 7.7e-66 Calmodulin-binding transcription activator 1 OS=Homo sapiens GN=CAMTA1 PE=1 SV=4 PF01833//PF00612//PF00023//PF03859//PF13606//PF00899//PF10371 IPT/TIG domain//IQ calmodulin-binding motif//Ankyrin repeat//CG-1 domain//Ankyrin repeat//ThiF family//Domain of unknown function GO:0055114 oxidation-reduction process GO:0008641//GO:0005515//GO:0016903//GO:0003677 small protein activating enzyme activity//protein binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors//DNA binding GO:0005634 nucleus KOG0520 Uncharacterized conserved protein, contains IPT/TIG domain Cluster-8309.46037 BP_3 25.37 0.97 1551 642919164 XP_008191764.1 1201 5.5e-129 PREDICTED: forkhead box protein N3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09407 FOXN forkhead box protein N http://www.genome.jp/dbget-bin/www_bget?ko:K09407 Q499D0 446 7.9e-43 Forkhead box protein N3 OS=Mus musculus GN=Foxn3 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.46039 BP_3 33.88 1.66 1274 189240236 XP_001811057.1 1228 3.3e-132 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 54 5.44312e-17 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q0V7M4 858 1.1e-90 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Bos taurus GN=SLC25A25 PE=2 SV=1 PF13499//PF10591//PF13833//PF00036//PF13405//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0036 Predicted mitochondrial carrier protein Cluster-8309.4604 BP_3 6.59 0.87 657 91093274 XP_971370.1 506 9.0e-49 PREDICTED: U6 snRNA-associated Sm-like protein LSm1 [Tribolium castaneum]>gi|270016827|gb|EFA13273.1| hypothetical protein TcasGA2_TC001544 [Tribolium castaneum] -- -- -- -- -- K12620 LSM1 U6 snRNA-associated Sm-like protein LSm1 http://www.genome.jp/dbget-bin/www_bget?ko:K12620 Q5E9Z8 380 1.5e-35 U6 snRNA-associated Sm-like protein LSm1 OS=Bos taurus GN=LSM1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1782 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.46040 BP_3 116.05 0.86 6780 649572237 NP_001280538.1 2012 2.2e-222 5-hydroxytryptamine receptor [Tribolium castaneum]>gi|510960964|gb|AGN56420.1| serotonin receptor type 1 [Tribolium castaneum] 195584787 XM_002082150.1 80 1.0424e-30 Drosophila simulans GD11428 (Dsim\GD11428), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25190 1208 1.5e-130 5-hydroxytryptamine receptor OS=Heliothis virescens PE=2 SV=1 PF00974//PF00001 Rhabdovirus spike glycoprotein//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.46042 BP_3 85.94 2.64 1858 546684200 ERL93905.1 259 1.1e-19 hypothetical protein D910_11191 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46043 BP_3 319.27 6.69 2591 91094007 XP_971310.1 1623 1.1e-177 PREDICTED: DENN domain-containing protein 1A isoform X1 [Tribolium castaneum]>gi|270016162|gb|EFA12610.1| hypothetical protein TcasGA2_TC006851 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 410 2.0e-38 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.46048 BP_3 1.00 5.73 259 642934270 XP_008200879.1 140 9.8e-07 PREDICTED: uncharacterized protein LOC103314998 isoform X28 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502K3 124 2.9e-06 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Danio rerio GN=ankrd52 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46049 BP_3 134.00 5.77 1412 154416570 XP_001581307.1 396 1.1e-35 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121915533|gb|EAY20321.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 360 6.8e-33 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023//PF02263//PF05396 Ankyrin repeat//Ankyrin repeat//Guanylate-binding protein, N-terminal domain//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0003924//GO:0005515//GO:0005525 GTPase activity//protein binding//GTP binding -- -- KOG4177 Ankyrin Cluster-8309.46050 BP_3 76.00 2.72 1638 780132859 XP_011679540.1 377 2.0e-33 PREDICTED: uncharacterized protein LOC105445556 [Strongylocentrotus purpuratus] -- -- -- -- -- K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q4UMH6 312 2.9e-27 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46051 BP_3 43.00 2.21 1230 642934260 XP_008200857.1 605 5.6e-60 PREDICTED: uncharacterized protein LOC103314998 isoform X23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 529 1.5e-52 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.46055 BP_3 31.60 0.86 2064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01132 Elongation factor P (EF-P) OB domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840 ribosome -- -- Cluster-8309.46056 BP_3 93.12 1.24 3916 642938306 XP_008192805.1 639 2.0e-63 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X3 [Tribolium castaneum] 642938305 XM_008194583.1 200 1.1763e-97 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X4, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 Q9VWW0 222 1.9e-16 Cyclic AMP response element-binding protein B OS=Drosophila melanogaster GN=CrebB PE=1 SV=1 PF07716//PF00170//PF02173//PF03131 Basic region leucine zipper//bZIP transcription factor//pKID domain//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.46057 BP_3 14.65 0.43 1933 642910932 XP_008193471.1 964 2.1e-101 PREDICTED: kinesin-like protein KIF13A isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4606 BP_3 11.00 0.49 1372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46060 BP_3 48.29 1.74 1631 478258496 ENN78571.1 1843 2.1e-203 hypothetical protein YQE_04939, partial [Dendroctonus ponderosae]>gi|546677392|gb|ERL88238.1| hypothetical protein D910_05626 [Dendroctonus ponderosae] 768436038 XM_011561181.1 53 2.52177e-16 PREDICTED: Plutella xylostella PRKCA-binding protein-like (LOC105389970), mRNA -- -- -- -- Q5REH1 1208 3.7e-131 PRKCA-binding protein OS=Pongo abelii GN=PICK1 PE=2 SV=1 PF13180//PF06456//PF00595 PDZ domain//Arfaptin-like domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0019904//GO:0005515 protein domain specific binding//protein binding -- -- KOG3651 Protein kinase C, alpha binding protein Cluster-8309.46062 BP_3 264.12 2.66 5085 642918584 XP_966986.2 1643 1.0e-179 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0NGI1 259 1.3e-20 Transmembrane protein 234 homolog OS=Anopheles gambiae GN=AGAP012180 PE=3 SV=1 PF16331//PF04977//PF13855//PF06005//PF00892//PF10392//PF07926//PF00560 TolA binding protein trimerisation//Septum formation initiator//Leucine rich repeat//Protein of unknown function (DUF904)//EamA-like transporter family//Golgi transport complex subunit 5//TPR/MLP1/MLP2-like protein//Leucine Rich Repeat GO:0006606//GO:0043093//GO:0000917//GO:0007049//GO:0006891//GO:0070206 protein import into nucleus//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle//intra-Golgi vesicle-mediated transport//protein trimerization GO:0005515 protein binding GO:0016020//GO:0017119//GO:0005737//GO:0016021 membrane//Golgi transport complex//cytoplasm//integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.46065 BP_3 893.14 2.62 16732 765150019 XP_011485511.1 427 3.3e-38 PREDICTED: ring-infected erythrocyte surface antigen-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- P25386 202 1.7e-13 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46066 BP_3 104.94 0.31 16485 765150019 XP_011485511.1 427 3.3e-38 PREDICTED: ring-infected erythrocyte surface antigen-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- P25386 202 1.7e-13 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46067 BP_3 465.55 4.88 4893 642930421 XP_008196394.1 3685 0.0e+00 PREDICTED: tyrosine-protein kinase hopscotch [Tribolium castaneum] 755985098 XM_011312437.1 47 1.66068e-12 PREDICTED: Fopius arisanus tyrosine-protein kinase hopscotch (LOC105271102), mRNA K04447 JAK2 Janus kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04447 Q24592 570 1.1e-56 Tyrosine-protein kinase hopscotch OS=Drosophila melanogaster GN=hop PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.46070 BP_3 40.69 17.89 400 270006872 EFA03320.1 172 2.9e-10 hypothetical protein TcasGA2_TC013263 [Tribolium castaneum] 642924012 XM_970745.2 112 9.24044e-50 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X2, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 155 1.1e-09 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00503 G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0019001//GO:0004871//GO:0031683 GTPase activity//guanyl nucleotide binding//signal transducer activity//G-protein beta/gamma-subunit complex binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46071 BP_3 251.00 12.40 1267 91083543 XP_975838.1 738 2.2e-75 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [Tribolium castaneum] 805773141 XM_012281746.1 191 3.76276e-93 PREDICTED: Megachile rotundata guanine nucleotide-binding protein G(o) subunit alpha (LOC100880970), transcript variant X3, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 722 6.4e-75 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00025//PF00503 ADP-ribosylation factor family//G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0005525//GO:0031683//GO:0019001//GO:0004871 GTPase activity//GTP binding//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46072 BP_3 75.29 3.22 1420 826420612 XP_012525240.1 917 4.3e-96 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Monomorium pharaonis] 642924011 XM_961328.2 321 2.28952e-165 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X1, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 915 3.0e-97 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00025//PF01580//PF00503 ADP-ribosylation factor family//FtsK/SpoIIIE family//G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0000166//GO:0019001//GO:0004871//GO:0005524//GO:0031683//GO:0003677//GO:0003924 GTP binding//nucleotide binding//guanyl nucleotide binding//signal transducer activity//ATP binding//G-protein beta/gamma-subunit complex binding//DNA binding//GTPase activity -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46073 BP_3 52.61 1.79 1712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46074 BP_3 152.00 16.72 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46076 BP_3 4.00 5.60 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4608 BP_3 92.83 2.13 2389 642934709 XP_008197779.1 1054 9.4e-112 PREDICTED: condensin complex subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15003 375 2.1e-34 Condensin complex subunit 2 OS=Homo sapiens GN=NCAPH PE=1 SV=3 PF08655//PF05786 DASH complex subunit Ask1//Condensin complex subunit 2 GO:0008608//GO:0007076 attachment of spindle microtubules to kinetochore//mitotic chromosome condensation -- -- GO:0042729//GO:0072686//GO:0000796 DASH complex//mitotic spindle//condensin complex KOG2328 Chromosome condensation complex Condensin, subunit H Cluster-8309.46081 BP_3 9.00 0.89 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46084 BP_3 4.00 0.35 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46085 BP_3 11.85 0.60 1241 531445092 AGT57838.1 365 3.8e-32 cytochrome P450 413a1 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27902 212 8.7e-16 Cytochrome P450 6B4 OS=Papilio glaucus GN=CYP6B4 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.46087 BP_3 45.00 3.30 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46090 BP_3 227.00 11.18 1270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46094 BP_3 13.21 0.50 1561 826420612 XP_012525240.1 917 4.7e-96 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Monomorium pharaonis] 642924011 XM_961328.2 321 2.5226e-165 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X1, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 915 3.3e-97 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF01580//PF00025//PF00503 FtsK/SpoIIIE family//ADP-ribosylation factor family//G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003677//GO:0031683//GO:0005524//GO:0003924//GO:0004871//GO:0019001//GO:0005525//GO:0000166 DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//signal transducer activity//guanyl nucleotide binding//GTP binding//nucleotide binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46096 BP_3 163.33 8.73 1194 826420612 XP_012525240.1 954 1.8e-100 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Monomorium pharaonis] 642924011 XM_961328.2 327 8.85108e-169 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X1, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 952 1.3e-101 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF08477//PF00503//PF00025//PF01580//PF04670 Ras of Complex, Roc, domain of DAPkinase//G-protein alpha subunit//ADP-ribosylation factor family//FtsK/SpoIIIE family//Gtr1/RagA G protein conserved region GO:0007264//GO:0007186//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0000166//GO:0005525//GO:0019001//GO:0004871//GO:0003924//GO:0005524//GO:0031683//GO:0003677 nucleotide binding//GTP binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//DNA binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46099 BP_3 152.10 1.26 6117 478256710 ENN76892.1 1622 3.3e-177 hypothetical protein YQE_06733, partial [Dendroctonus ponderosae]>gi|546685091|gb|ERL94618.1| hypothetical protein D910_11895 [Dendroctonus ponderosae] 749732005 XM_011139608.1 230 3.87931e-114 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1360 3.3e-148 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF07714//PF01762//PF02434//PF06293//PF00069//PF13414 Protein tyrosine kinase//Galactosyltransferase//Fringe-like//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//TPR repeat GO:0006486//GO:0006468 protein glycosylation//protein phosphorylation GO:0008378//GO:0004672//GO:0016773//GO:0005515//GO:0005524//GO:0016757 galactosyltransferase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//protein binding//ATP binding//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.461 BP_3 11.87 0.96 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4610 BP_3 5.09 0.51 777 546672740 ERL84510.1 159 1.8e-08 hypothetical protein D910_01940 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46100 BP_3 87.00 2.24 2162 642923314 XP_972670.2 1929 2.9e-213 PREDICTED: T-box transcription factor TBX20 [Tribolium castaneum] 642923313 XM_967577.2 521 0 PREDICTED: Tribolium castaneum H15 protein (LOC661420), mRNA K10185 TBX20 T-box protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10185 Q94890 986 2.7e-105 T-box protein H15 OS=Drosophila melanogaster GN=H15 PE=2 SV=2 PF00907 T-box GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3586 TBX1 and related T-box transcription factors Cluster-8309.46101 BP_3 211.83 1.26 8364 642933138 XP_008197272.1 7411 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 13 isoform X1 [Tribolium castaneum] 642933139 XM_008199051.1 239 5.27301e-119 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 3.1e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF02671//PF06333 Paired amphipathic helix repeat//Mediator complex subunit 13 C-terminal GO:0006355//GO:0006357 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.46102 BP_3 265.52 2.82 4828 478251982 ENN72418.1 2639 3.1e-295 hypothetical protein YQE_10936, partial [Dendroctonus ponderosae] 562831337 XM_006145090.1 42 9.86098e-10 PREDICTED: Tupaia chinensis tripartite motif containing 24 (TRIM24), mRNA K08883 TRIM33, TIF1G tripartite motif-containing protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K08883 Q56R14 487 4.4e-47 E3 ubiquitin-protein ligase TRIM33 OS=Xenopus laevis GN=trim33 PE=1 SV=1 PF13639//PF00439//PF01361//PF00097//PF00643//PF14634//PF00628 Ring finger domain//Bromodomain//Tautomerase enzyme//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger//zinc-RING finger domain//PHD-finger GO:0006725 cellular aromatic compound metabolic process GO:0008270//GO:0005515//GO:0046872//GO:0016853 zinc ion binding//protein binding//metal ion binding//isomerase activity GO:0005622 intracellular -- -- Cluster-8309.46103 BP_3 78.34 1.57 2700 91079885 XP_967890.1 570 1.4e-55 PREDICTED: tRNA methyltransferase 112 homolog [Tribolium castaneum]>gi|270004559|gb|EFA01007.1| hypothetical protein TcasGA2_TC003920 [Tribolium castaneum] -- -- -- -- -- K15448 TRM112, TRMT112 multifunctional methyltransferase subunit TRM112 http://www.genome.jp/dbget-bin/www_bget?ko:K15448 Q9DCG9 366 2.6e-33 Multifunctional methyltransferase subunit TRM112-like protein OS=Mus musculus GN=Trmt112 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1088 Uncharacterized conserved protein Cluster-8309.46106 BP_3 59.39 3.50 1110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46109 BP_3 1.00 0.43 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4611 BP_3 5.00 1.60 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46110 BP_3 219.00 64.89 454 817056880 XP_012269325.1 158 1.4e-08 PREDICTED: uncharacterized protein LOC105693774 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46111 BP_3 322.00 34.39 743 91094513 XP_971885.1 559 7.3e-55 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [Tribolium castaneum]>gi|270001243|gb|EEZ97690.1| lethal neo18 [Tribolium castaneum] -- -- -- -- -- K03961 NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03961 Q02380 236 8.5e-19 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial OS=Bos taurus GN=NDUFB5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46112 BP_3 15.72 1.11 973 641681966 XP_008189661.1 241 7.2e-18 PREDICTED: general transcription factor II-I repeat domain-containing protein 2-like, partial [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- A4IFA3 190 2.4e-13 General transcription factor II-I repeat domain-containing protein 2 OS=Bos taurus GN=GTF2IRD2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46114 BP_3 8.12 0.60 948 478260882 ENN80519.1 270 3.0e-21 hypothetical protein YQE_03058, partial [Dendroctonus ponderosae]>gi|546671739|gb|ERL83923.1| hypothetical protein D910_01216 [Dendroctonus ponderosae]>gi|546675041|gb|ERL86299.1| hypothetical protein D910_03707 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04814 Hepatocyte nuclear factor 1 (HNF-1), N terminus GO:0045893 positive regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.46115 BP_3 31.74 0.31 5192 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46117 BP_3 178.76 2.78 3390 91093659 XP_966349.1 2937 0.0e+00 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] 686775201 LM127048.1 46 4.12457e-12 Taenia asiatica genome assembly T_asiatica_South_Korea ,scaffold TASK_contig0000687 K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 Q9W3K5 2018 9.0e-225 Glutamate--cysteine ligase OS=Drosophila melanogaster GN=Gclc PE=2 SV=1 PF03074//PF00355 Glutamate-cysteine ligase//Rieske [2Fe-2S] domain GO:0006749//GO:0055114//GO:0006750 glutathione metabolic process//oxidation-reduction process//glutathione biosynthetic process GO:0051537//GO:0016491//GO:0004357 2 iron, 2 sulfur cluster binding//oxidoreductase activity//glutamate-cysteine ligase activity GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.46118 BP_3 357.76 4.20 4394 91093659 XP_966349.1 2003 1.6e-221 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] 686775201 LM127048.1 46 5.35923e-12 Taenia asiatica genome assembly T_asiatica_South_Korea ,scaffold TASK_contig0000687 K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 P19468 1367 3.6e-149 Glutamate--cysteine ligase catalytic subunit OS=Rattus norvegicus GN=Gclc PE=1 SV=2 PF03074//PF00355 Glutamate-cysteine ligase//Rieske [2Fe-2S] domain GO:0006749//GO:0006750//GO:0055114 glutathione metabolic process//glutathione biosynthetic process//oxidation-reduction process GO:0051537//GO:0004357//GO:0016491 2 iron, 2 sulfur cluster binding//glutamate-cysteine ligase activity//oxidoreductase activity GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.46119 BP_3 3.00 3.89 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46120 BP_3 61.19 1.81 1922 91093659 XP_966349.1 777 1.0e-79 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] -- -- -- -- -- K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 Q9NFN6 417 2.3e-39 Glutamate--cysteine ligase OS=Onchocerca volvulus GN=gcs-1 PE=2 SV=2 PF03074 Glutamate-cysteine ligase GO:0006750//GO:0006749 glutathione biosynthetic process//glutathione metabolic process GO:0004357 glutamate-cysteine ligase activity GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.46121 BP_3 103.26 0.99 5300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46123 BP_3 4.52 0.36 893 91082769 XP_973660.1 499 8.0e-48 PREDICTED: probable peroxisomal acyl-coenzyme A oxidase 1 [Tribolium castaneum]>gi|270015082|gb|EFA11530.1| hypothetical protein TcasGA2_TC014245 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q7KML2 425 1.2e-40 Probable peroxisomal acyl-coenzyme A oxidase 1 OS=Drosophila melanogaster GN=CG5009 PE=1 SV=1 PF02770//PF01484//PF04414 Acyl-CoA dehydrogenase, middle domain//Nematode cuticle collagen N-terminal domain//D-aminoacyl-tRNA deacylase GO:0006118//GO:0055114//GO:0006637//GO:0006635 obsolete electron transport//oxidation-reduction process//acyl-CoA metabolic process//fatty acid beta-oxidation GO:0003997//GO:0050660//GO:0051499//GO:0016788//GO:0003995//GO:0042302 acyl-CoA oxidase activity//flavin adenine dinucleotide binding//D-aminoacyl-tRNA deacylase activity//hydrolase activity, acting on ester bonds//acyl-CoA dehydrogenase activity//structural constituent of cuticle GO:0005777 peroxisome KOG0136 Acyl-CoA oxidase Cluster-8309.46125 BP_3 9.28 0.50 1183 780089478 XP_011673857.1 292 1.1e-23 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- K08803 DAPK death-associated protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08803 Q8N8A2 234 2.3e-18 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens GN=ANKRD44 PE=1 SV=3 PF00023//PF13606//PF05396 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- -- -- Cluster-8309.46126 BP_3 15.00 2.97 535 123507472 XP_001329422.1 295 2.2e-24 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121912377|gb|EAY17199.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10324 ASB2 ankyrin repeat and SOCS box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10324 Q9J569 240 2.1e-19 Putative ankyrin repeat protein FPV162 OS=Fowlpox virus (strain NVSL) GN=FPV162 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46127 BP_3 46.13 0.56 4272 478253248 ENN73619.1 690 2.7e-69 hypothetical protein YQE_09866, partial [Dendroctonus ponderosae] -- -- -- -- -- K15277 SLC35B3, PAPST2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 http://www.genome.jp/dbget-bin/www_bget?ko:K15277 Q7Q5D4 522 3.4e-51 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Anopheles gambiae GN=Papst2 PE=3 SV=4 PF08449//PF00892 UAA transporter family//EamA-like transporter family GO:0055085 transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1582 UDP-galactose transporter related protein Cluster-8309.46128 BP_3 22.58 0.35 3422 642936562 XP_008198486.1 1449 2.1e-157 PREDICTED: somatostatin receptor type 2 isoform X1 [Tribolium castaneum] 462360042 APGK01029530.1 119 1.09402e-52 Dendroctonus ponderosae Seq01029540, whole genome shotgun sequence K04218 SSTR2 somatostatin receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04218 P30874 580 5.1e-58 Somatostatin receptor type 2 OS=Homo sapiens GN=SSTR2 PE=1 SV=1 PF13994//PF00001 PgaD-like protein//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0042710 G-protein coupled receptor signaling pathway//biofilm formation GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.46129 BP_3 13.40 0.32 2282 642926882 XP_008195051.1 1690 1.6e-185 PREDICTED: probable cation-transporting ATPase 13A3 isoform X3 [Tribolium castaneum] 759064686 XM_011343453.1 68 1.62863e-24 PREDICTED: Cerapachys biroi probable cation-transporting ATPase 13A3 (LOC105281898), transcript variant X2, mRNA K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 985 3.7e-105 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF06399//PF00122 P5-type ATPase cation transporter//GTP cyclohydrolase I feedback regulatory protein (GFRP)//E1-E2 ATPase GO:0009890//GO:0006812 negative regulation of biosynthetic process//cation transport GO:0046872//GO:0016887//GO:0000166 metal ion binding//ATPase activity//nucleotide binding GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.4613 BP_3 6.00 1.66 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46130 BP_3 82.33 2.44 1918 91076534 XP_973776.1 777 9.9e-80 PREDICTED: snRNA-activating protein complex subunit 3 [Tribolium castaneum]>gi|270002398|gb|EEZ98845.1| hypothetical protein TcasGA2_TC004455 [Tribolium castaneum] -- -- -- -- -- K15210 SNAPC3 snRNA-activating protein complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15210 Q5E9M5 334 9.6e-30 snRNA-activating protein complex subunit 3 OS=Bos taurus GN=SNAPC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2664 Small nuclear RNA activating protein complex - 50kD subunit (SNAP50) Cluster-8309.46131 BP_3 1529.01 4.96 15155 546683698 ERL93476.1 2777 1.2e-310 hypothetical protein D910_10767, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF07535 Zinc finger, C2H2 type//DBF zinc finger -- -- GO:0046872//GO:0008270//GO:0003676 metal ion binding//zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.46132 BP_3 32.71 0.40 4273 642927998 XP_008195478.1 2546 1.7e-284 PREDICTED: LOW QUALITY PROTEIN: DNA replication licensing factor Mcm5 [Tribolium castaneum] 686484113 KM036513.1 190 4.65281e-92 Locusta migratoria Mcm5 mRNA, complete cds K02209 MCM5, CDC46 DNA replication licensing factor MCM5 http://www.genome.jp/dbget-bin/www_bget?ko:K02209 Q9VGW6 2277 1.1e-254 DNA replication licensing factor Mcm5 OS=Drosophila melanogaster GN=Mcm5 PE=1 SV=1 PF00493//PF00004//PF07728//PF07726//PF00158 MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008134//GO:0016887//GO:0003677//GO:0005524 transcription factor binding//ATPase activity//DNA binding//ATP binding GO:0005667 transcription factor complex KOG0481 DNA replication licensing factor, MCM5 component Cluster-8309.46133 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46134 BP_3 7.90 0.45 1145 546684523 ERL94154.1 570 6.0e-56 hypothetical protein D910_11436 [Dendroctonus ponderosae] -- -- -- -- -- K13142 INTS5 integrator complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13142 Q6P9B9 260 2.2e-21 Integrator complex subunit 5 OS=Homo sapiens GN=INTS5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46135 BP_3 375.00 8.21 2492 546684523 ERL94154.1 2540 4.8e-284 hypothetical protein D910_11436 [Dendroctonus ponderosae] -- -- -- -- -- K13142 INTS5 integrator complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13142 Q8CHT3 675 3.6e-69 Integrator complex subunit 5 OS=Mus musculus GN=Ints5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46136 BP_3 18.06 1.52 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06858//PF02259 Nucleolar GTP-binding protein 1 (NOG1)//FAT domain -- -- GO:0005515//GO:0005525 protein binding//GTP binding -- -- -- -- Cluster-8309.46137 BP_3 28.68 2.78 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46138 BP_3 5.78 0.36 1056 270008621 EFA05069.1 151 2.1e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.46139 BP_3 44.15 0.91 2634 642926809 XP_008195022.1 416 9.9e-38 PREDICTED: zinc finger protein 64 homolog, isoforms 3 and 4-like [Tribolium castaneum]>gi|270009173|gb|EFA05621.1| hypothetical protein TcasGA2_TC015829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PVG3 262 2.9e-21 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF04120//PF01309//PF00096//PF13465//PF07776 Low affinity iron permease//Equine arteritis virus small envelope glycoprotein//Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) GO:0055085 transmembrane transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0019031//GO:0005634 viral envelope//nucleus -- -- Cluster-8309.4614 BP_3 8.00 3.89 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46140 BP_3 61.85 0.41 7634 91086723 XP_970869.1 1361 7.6e-147 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 2.02164e-08 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 757 3.4e-78 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF02535//PF08022 ZIP Zinc transporter//FAD-binding domain GO:0030001//GO:0055085//GO:0055114 metal ion transport//transmembrane transport//oxidation-reduction process GO:0046873//GO:0016491 metal ion transmembrane transporter activity//oxidoreductase activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.46141 BP_3 68.65 1.12 3233 642914563 XP_008201731.1 497 4.9e-47 PREDICTED: histone-lysine N-methyltransferase ash1 isoform X2 [Tribolium castaneum]>gi|270001477|gb|EEZ97924.1| hypothetical protein TcasGA2_TC000311 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0032259 methylation GO:0008168//GO:0043169 methyltransferase activity//cation binding -- -- -- -- Cluster-8309.46142 BP_3 59.78 0.98 3217 91083297 XP_974591.1 1894 5.0e-209 PREDICTED: probable cysteine desulfurase, mitochondrial [Tribolium castaneum]>gi|270007737|gb|EFA04185.1| hypothetical protein TcasGA2_TC014434 [Tribolium castaneum] -- -- -- -- -- K04487 iscS, NFS1 cysteine desulfurase http://www.genome.jp/dbget-bin/www_bget?ko:K04487 Q9VKD3 1773 2.2e-196 Probable cysteine desulfurase, mitochondrial OS=Drosophila melanogaster GN=CG12264 PE=2 SV=1 PF08477//PF01926//PF00025//PF03193//PF00282//PF01212//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Protein of unknown function, DUF258//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//Gtr1/RagA G protein conserved region//Ras family GO:0006520//GO:0007264//GO:0019752//GO:0008152 cellular amino acid metabolic process//small GTPase mediated signal transduction//carboxylic acid metabolic process//metabolic process GO:0016829//GO:0005525//GO:0003924//GO:0030170//GO:0016831//GO:0003824 lyase activity//GTP binding//GTPase activity//pyridoxal phosphate binding//carboxy-lyase activity//catalytic activity -- -- KOG1549 Cysteine desulfurase NFS1 Cluster-8309.46143 BP_3 241.75 2.03 6031 642923145 XP_008193629.1 2730 1.1e-305 PREDICTED: nuclear receptor coactivator 1 isoform X8 [Tribolium castaneum] 642923146 XM_008195408.1 411 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.1e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.46144 BP_3 758.41 16.34 2529 270013857 EFA10305.1 160 4.6e-08 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46145 BP_3 196.38 2.00 5034 642932649 XP_969929.2 1247 8.3e-134 PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15112 SLC25A27, UCP4 solute carrier family 25 (mitochondrial uncoupling protein), member 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15112 O95847 886 2.5e-93 Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.46147 BP_3 27.52 0.53 2777 91084661 XP_967669.1 1706 2.7e-187 PREDICTED: protein phosphatase 1D [Tribolium castaneum]>gi|270008629|gb|EFA05077.1| hypothetical protein TcasGA2_TC015174 [Tribolium castaneum] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 728 2.8e-75 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481 Protein phosphatase 2C GO:0006470 protein dephosphorylation GO:0004722//GO:0046872//GO:0003824 protein serine/threonine phosphatase activity//metal ion binding//catalytic activity GO:0008287 protein serine/threonine phosphatase complex KOG0698 Serine/threonine protein phosphatase Cluster-8309.46150 BP_3 21.13 0.37 3008 478253953 ENN74245.1 1772 6.5e-195 hypothetical protein YQE_09217, partial [Dendroctonus ponderosae]>gi|546674841|gb|ERL86127.1| hypothetical protein D910_03541 [Dendroctonus ponderosae] 150013142 CP000743.1 37 3.68075e-07 Methanococcus aeolicus Nankai-3, complete genome K07767 KATNA1 katanin p60 ATPase-containing subunit A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07767 B4USW8 1439 1.1e-157 Katanin p60 ATPase-containing subunit A-like 1 OS=Otolemur garnettii GN=KATNAL1 PE=3 SV=1 PF05496//PF01080//PF06068//PF01695//PF07728//PF03286//PF07724//PF00004//PF02562//PF02367//PF00910 Holliday junction DNA helicase ruvB N-terminus//Presenilin//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Pox virus Ag35 surface protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase GO:0006281//GO:0006310//GO:0002949 DNA repair//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0004190//GO:0003723//GO:0003678//GO:0005524//GO:0016887//GO:0003724//GO:0009378 aspartic-type endopeptidase activity//RNA binding//DNA helicase activity//ATP binding//ATPase activity//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0016021//GO:0019031 Holliday junction helicase complex//replication fork//integral component of membrane//viral envelope KOG0738 AAA+-type ATPase Cluster-8309.46151 BP_3 219.01 2.93 3898 642918805 XP_008191593.1 3364 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 2055 5.3e-229 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF00122 P5-type ATPase cation transporter//E1-E2 ATPase GO:0006812 cation transport GO:0046872//GO:0016887//GO:0000166 metal ion binding//ATPase activity//nucleotide binding GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.46155 BP_3 110.46 2.42 2489 642911714 XP_008200711.1 682 1.3e-68 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 557 1.7e-55 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF09339//PF01118 short chain dehydrogenase//IclR helix-turn-helix domain//Semialdehyde dehydrogenase, NAD binding domain GO:0055114//GO:0008152//GO:0006355 oxidation-reduction process//metabolic process//regulation of transcription, DNA-templated GO:0051287//GO:0016620//GO:0016491//GO:0003677 NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity//DNA binding -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.46157 BP_3 240.07 2.19 5578 642919894 XP_008192113.1 2193 1.8e-243 PREDICTED: mucin-17 isoform X1 [Tribolium castaneum]>gi|642919896|ref|XP_008192115.1| PREDICTED: mucin-17 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46160 BP_3 302.24 2.32 6570 642928935 XP_008195623.1 2125 1.7e-235 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K17426 MRPL45 large subunit ribosomal protein L45 http://www.genome.jp/dbget-bin/www_bget?ko:K17426 Q9VCX1 1021 7.1e-109 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF00788//PF02188//PF00595//PF02196//PF07961//PF13180 Ras association (RalGDS/AF-6) domain//GoLoco motif//PDZ domain (Also known as DHR or GLGF)//Raf-like Ras-binding domain//MBA1-like protein//PDZ domain GO:0032979//GO:0007165 protein insertion into mitochondrial membrane from inner side//signal transduction GO:0005515//GO:0030695//GO:0005057 protein binding//GTPase regulator activity//receptor signaling protein activity GO:0005743 mitochondrial inner membrane KOG4599 Putative mitochondrial/chloroplast ribosomal protein L45 Cluster-8309.46161 BP_3 85.91 0.40 10682 642928935 XP_008195623.1 1843 1.4e-202 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K17426 MRPL45 large subunit ribosomal protein L45 http://www.genome.jp/dbget-bin/www_bget?ko:K17426 Q9VCX1 1021 1.2e-108 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF00788//PF02196//PF07961//PF15170//PF02188 Ras association (RalGDS/AF-6) domain//Raf-like Ras-binding domain//MBA1-like protein//Calcium/calmodulin-dependent protein kinase II inhibitor//GoLoco motif GO:0007165//GO:0032979//GO:0045859 signal transduction//protein insertion into mitochondrial membrane from inner side//regulation of protein kinase activity GO:0005057//GO:0030695//GO:0004860 receptor signaling protein activity//GTPase regulator activity//protein kinase inhibitor activity GO:0005743 mitochondrial inner membrane KOG4599 Putative mitochondrial/chloroplast ribosomal protein L45 Cluster-8309.46163 BP_3 4410.02 73.24 3194 478257607 ENN77759.1 781 5.7e-80 hypothetical protein YQE_05731, partial [Dendroctonus ponderosae]>gi|546677511|gb|ERL88337.1| hypothetical protein D910_05724, partial [Dendroctonus ponderosae] -- -- -- -- -- K09880 mtnC, ENOPH1 enolase-phosphatase E1 http://www.genome.jp/dbget-bin/www_bget?ko:K09880 Q17Q32 461 3.0e-44 Enolase-phosphatase E1 OS=Aedes aegypti GN=AAEL000109 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2630 Enolase-phosphatase E-1 Cluster-8309.46164 BP_3 528.79 23.04 1398 478250783 ENN71275.1 862 1.0e-89 hypothetical protein YQE_12200, partial [Dendroctonus ponderosae]>gi|546673018|gb|ERL84704.1| hypothetical protein D910_02129 [Dendroctonus ponderosae] -- -- -- -- -- K06999 K06999 phospholipase/carboxylesterase http://www.genome.jp/dbget-bin/www_bget?ko:K06999 Q3UFF7 515 7.1e-51 Lysophospholipase-like protein 1 OS=Mus musculus GN=Lyplal1 PE=1 SV=3 PF01764//PF07859//PF02230//PF00326//PF03583//PF00975//PF01738 Lipase (class 3)//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Secretory lipase//Thioesterase domain//Dienelactone hydrolase family GO:0006508//GO:0016042//GO:0009058//GO:0046486//GO:0008152//GO:0006629 proteolysis//lipid catabolic process//biosynthetic process//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0008236//GO:0016788//GO:0016787//GO:0004806 serine-type peptidase activity//hydrolase activity, acting on ester bonds//hydrolase activity//triglyceride lipase activity -- -- KOG2112 Lysophospholipase Cluster-8309.46165 BP_3 66.45 0.37 8879 642938747 XP_008199872.1 1850 1.7e-203 PREDICTED: cytosolic purine 5'-nucleotidase isoform X2 [Tribolium castaneum] 41393060 NM_201427.1 39 8.46269e-08 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1401 8.3e-153 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.46167 BP_3 107.54 0.90 6074 642933274 XP_008197353.1 2089 2.3e-231 PREDICTED: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 [Tribolium castaneum] 850480667 CP011888.1 37 7.47792e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 822 7.8e-86 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF01612//PF03798//PF09061//PF00443 3'-5' exonuclease//TLC domain//Stirrup//Ubiquitin carboxyl-terminal hydrolase GO:0006139//GO:0016579 nucleobase-containing compound metabolic process//protein deubiquitination GO:0016788//GO:0036459//GO:0003676//GO:0008408 hydrolase activity, acting on ester bonds//ubiquitinyl hydrolase activity//nucleic acid binding//3'-5' exonuclease activity GO:0016021 integral component of membrane KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.46168 BP_3 4954.06 257.79 1218 642934605 XP_971300.2 782 1.7e-80 PREDICTED: CD63 antigen [Tribolium castaneum] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q9XSK2 375 1.1e-34 CD63 antigen OS=Bos taurus GN=CD63 PE=2 SV=4 PF13520//PF00115//PF09004//PF00335//PF05149 Amino acid permease//Cytochrome C and Quinol oxidase polypeptide I//Domain of unknown function (DUF1891)//Tetraspanin family//Paraflagellar rod protein GO:0003333//GO:0006865//GO:0015992//GO:0055114//GO:0006118//GO:0006123//GO:0009060 amino acid transmembrane transport//amino acid transport//proton transport//oxidation-reduction process//obsolete electron transport//mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration GO:0004129//GO:0020037//GO:0016706//GO:0009055//GO:0005506//GO:0008168//GO:0005516//GO:0015171 cytochrome-c oxidase activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//electron carrier activity//iron ion binding//methyltransferase activity//calmodulin binding//amino acid transmembrane transporter activity GO:0016020//GO:0045277//GO:0016021//GO:0031514 membrane//respiratory chain complex IV//integral component of membrane//motile cilium KOG3882 Tetraspanin family integral membrane protein Cluster-8309.46172 BP_3 71.25 0.97 3826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46175 BP_3 771.86 5.42 7159 642912303 XP_008200641.1 1230 1.1e-131 PREDICTED: protein couch potato isoform X3 [Tribolium castaneum] 642912304 XM_008202420.1 406 0 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X4, mRNA -- -- -- -- Q01617 784 2.4e-81 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00168//PF00076 C2 domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.46176 BP_3 25.76 0.34 3977 642912719 XP_008200974.1 1391 1.3e-150 PREDICTED: tyrosine kinase receptor Cad96Ca isoform X1 [Tribolium castaneum] -- -- -- -- -- K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 Q9VBW3 571 6.5e-57 Tyrosine kinase receptor Cad96Ca OS=Drosophila melanogaster GN=Cad96Ca PE=2 SV=2 PF16622//PF00069//PF07714//PF00028 zinc-finger C2H2-type//Protein kinase domain//Protein tyrosine kinase//Cadherin domain GO:0007156//GO:0006468 homophilic cell adhesion via plasma membrane adhesion molecules//protein phosphorylation GO:0005524//GO:0005509//GO:0004672//GO:0046872 ATP binding//calcium ion binding//protein kinase activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.46177 BP_3 2343.62 32.14 3806 642912719 XP_008200974.1 2258 3.7e-251 PREDICTED: tyrosine kinase receptor Cad96Ca isoform X1 [Tribolium castaneum] -- -- -- -- -- K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 Q9VBW3 1351 2.2e-147 Tyrosine kinase receptor Cad96Ca OS=Drosophila melanogaster GN=Cad96Ca PE=2 SV=2 PF16622//PF00069//PF06293//PF00028//PF07714 zinc-finger C2H2-type//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Cadherin domain//Protein tyrosine kinase GO:0007156//GO:0006468 homophilic cell adhesion via plasma membrane adhesion molecules//protein phosphorylation GO:0005524//GO:0016773//GO:0005509//GO:0004672//GO:0046872 ATP binding//phosphotransferase activity, alcohol group as acceptor//calcium ion binding//protein kinase activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.46178 BP_3 1082.00 15.37 3685 546682477 ERL92400.1 3247 0.0e+00 hypothetical protein D910_09714 [Dendroctonus ponderosae] 820864418 XM_012493351.1 157 8.85991e-74 PREDICTED: Apis florea structural maintenance of chromosomes protein 2 (LOC100863079), transcript variant X1, mRNA K06674 SMC2 structural maintenance of chromosome 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06674 P50533 2622 9.0e-295 Structural maintenance of chromosomes protein 2 OS=Xenopus laevis GN=smc2 PE=1 SV=1 PF13304//PF06470 AAA domain, putative AbiEii toxin, Type IV TA system//SMC proteins Flexible Hinge Domain GO:0051276 chromosome organization GO:0005515//GO:0005524 protein binding//ATP binding GO:0005694 chromosome KOG0933 Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin, subunit E) Cluster-8309.46181 BP_3 258.44 2.46 5361 642935257 XP_008197935.1 1482 4.9e-161 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 424 9.8e-40 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.46184 BP_3 54.00 4.56 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46187 BP_3 517.55 18.72 1624 642915257 XP_008190546.1 1047 4.1e-111 PREDICTED: alpha-tubulin N-acetyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K19573 ATAT1, MEC17 alpha-tubulin N-acetyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19573 Q16Y34 630 3.8e-64 Alpha-tubulin N-acetyltransferase OS=Aedes aegypti GN=AAEL008679 PE=3 SV=1 PF13673//PF05301//PF03494//PF13508//PF00583 Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Beta-amyloid peptide (beta-APP)//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967//GO:0071929 acyl-carrier-protein biosynthetic process//alpha-tubulin acetylation GO:0008080//GO:0019799 N-acetyltransferase activity//tubulin N-acetyltransferase activity GO:0005874//GO:0045298//GO:0016021 microtubule//tubulin complex//integral component of membrane KOG4601 Uncharacterized conserved protein Cluster-8309.46189 BP_3 6.00 2.00 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46190 BP_3 27.68 0.34 4222 642926793 XP_008195018.1 3461 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 87 8.31458e-35 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2005 3.6e-223 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF01363//PF13606//PF00023//PF01155 FYVE zinc finger//Ankyrin repeat//Ankyrin repeat//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0016151//GO:0005515//GO:0046872 nickel cation binding//protein binding//metal ion binding -- -- KOG4177 Ankyrin Cluster-8309.46193 BP_3 241.64 1.79 6791 91087949 XP_972541.1 1210 2.2e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.0e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF12763//PF13606//PF13499//PF13833//PF10591//PF13405//PF13202//PF01694//PF00023//PF00036 Cytoskeletal-regulatory complex EF hand//Ankyrin repeat//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//Rhomboid family//Ankyrin repeat//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515//GO:0004252 calcium ion binding//protein binding//serine-type endopeptidase activity GO:0016021//GO:0005578 integral component of membrane//proteinaceous extracellular matrix KOG2289 Rhomboid family proteins Cluster-8309.46194 BP_3 225.72 20.52 822 215820608 NP_001135963.1 334 1.0e-28 autophagy related protein Atg12-like protein [Bombyx mori]>gi|213390048|gb|ACJ46063.1| autophagy related protein Atg12-like protein [Bombyx mori] -- -- -- -- -- K08336 ATG12 ubiquitin-like protein ATG12 http://www.genome.jp/dbget-bin/www_bget?ko:K08336 Q9VTU1 274 3.7e-23 Autophagy protein 12-like OS=Drosophila melanogaster GN=Atg12 PE=3 SV=3 PF08727//PF04110 Poliovirus 3A protein like//Ubiquitin-like autophagy protein Apg12 GO:0006508//GO:0006144//GO:0000045 proteolysis//purine nucleobase metabolic process//autophagosome assembly GO:0017111//GO:0004197//GO:0003968 nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0005737//GO:0031379 cytoplasm//RNA-directed RNA polymerase complex KOG3439 Protein conjugation factor involved in autophagy Cluster-8309.46195 BP_3 36.88 0.58 3336 91089353 XP_972936.1 590 8.3e-58 PREDICTED: coiled-coil domain-containing protein 137 [Tribolium castaneum]>gi|270012523|gb|EFA08971.1| hypothetical protein TcasGA2_TC006678 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XYN1 370 1.1e-33 Innexin inx2 OS=Schistocerca americana GN=inx2 PE=1 SV=1 PF00876//PF08587 Innexin//Ubiquitin associated domain (UBA) GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674 protein serine/threonine kinase activity GO:0005921 gap junction -- -- Cluster-8309.46196 BP_3 129.58 1.33 4998 642913613 XP_008201088.1 3914 0.0e+00 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X3 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q5PQN1 2206 2.1e-246 Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0941 E3 ubiquitin protein ligase Cluster-8309.46197 BP_3 60.37 7.01 707 478259947 ENN79749.1 609 1.1e-60 hypothetical protein YQE_03805, partial [Dendroctonus ponderosae]>gi|546681497|gb|ERL91574.1| hypothetical protein D910_08904 [Dendroctonus ponderosae] 533121362 XM_005376003.1 92 2.22251e-38 PREDICTED: Chinchilla lanigera glutamine-fructose-6-phosphate transaminase 2 (Gfpt2), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q9Z2Z9 513 6.2e-51 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Mus musculus GN=Gfpt2 PE=2 SV=3 PF01380 SIS domain GO:0005975 carbohydrate metabolic process GO:0030246 carbohydrate binding -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.46199 BP_3 115.27 5.32 1336 91086881 XP_970132.1 1278 5.6e-138 PREDICTED: RING finger protein 113A [Tribolium castaneum]>gi|270010474|gb|EFA06922.1| hypothetical protein TcasGA2_TC009871 [Tribolium castaneum] 195450055 XM_002072309.1 74 4.35627e-28 Drosophila willistoni GK22373 (Dwil\GK22373), mRNA K13127 RNF113A, CWC24 RING finger protein 113A http://www.genome.jp/dbget-bin/www_bget?ko:K13127 O15541 956 5.0e-102 RING finger protein 113A OS=Homo sapiens GN=RNF113A PE=1 SV=1 PF13639//PF16685//PF11789//PF00097//PF03854//PF00642//PF14634 Ring finger domain//zinc RING finger of MSL2//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//P-11 zinc finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//zinc-RING finger domain -- -- GO:0061630//GO:0046872//GO:0005515//GO:0003723//GO:0008270//GO:0003676 ubiquitin protein ligase activity//metal ion binding//protein binding//RNA binding//zinc ion binding//nucleic acid binding -- -- KOG1813 Predicted E3 ubiquitin ligase Cluster-8309.46200 BP_3 587.15 11.26 2805 478255270 ENN75499.1 1625 6.8e-178 hypothetical protein YQE_08048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46201 BP_3 62.84 1.03 3244 158294276 XP_001688670.1 383 8.2e-34 AGAP005507-PB [Anopheles gambiae str. PEST]>gi|158294278|ref|XP_001688671.1| AGAP005507-PA [Anopheles gambiae str. PEST]>gi|157015489|gb|EDO63676.1| AGAP005507-PB [Anopheles gambiae str. PEST]>gi|157015490|gb|EDO63677.1| AGAP005507-PA [Anopheles gambiae str. PEST] 768430547 XM_011558205.1 125 4.78842e-56 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105387473), transcript variant X3, mRNA >gnl|BL_ORD_ID|28135220 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105389571), transcript variant X3, mRNA K13504 VAMP2 vesicle-associated membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13504 P47194 284 1.0e-23 Synaptobrevin OS=Doryteuthis pealeii PE=1 SV=1 PF04799//PF00963//PF07352//PF00957//PF00517 fzo-like conserved region//Cohesin domain//Bacteriophage Mu Gam like protein//Synaptobrevin//Retroviral envelope protein GO:0042262//GO:0016192//GO:0000272//GO:0008053 DNA protection//vesicle-mediated transport//polysaccharide catabolic process//mitochondrial fusion GO:0003924//GO:0005198//GO:0030246//GO:0003690 GTPase activity//structural molecule activity//carbohydrate binding//double-stranded DNA binding GO:0016021//GO:0019031//GO:0005741 integral component of membrane//viral envelope//mitochondrial outer membrane KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.46202 BP_3 87.77 1.45 3212 158294276 XP_001688670.1 383 8.1e-34 AGAP005507-PB [Anopheles gambiae str. PEST]>gi|158294278|ref|XP_001688671.1| AGAP005507-PA [Anopheles gambiae str. PEST]>gi|157015489|gb|EDO63676.1| AGAP005507-PB [Anopheles gambiae str. PEST]>gi|157015490|gb|EDO63677.1| AGAP005507-PA [Anopheles gambiae str. PEST] 768430547 XM_011558205.1 125 4.74065e-56 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105387473), transcript variant X3, mRNA >gnl|BL_ORD_ID|28135220 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105389571), transcript variant X3, mRNA K13504 VAMP2 vesicle-associated membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13504 P47194 284 1.0e-23 Synaptobrevin OS=Doryteuthis pealeii PE=1 SV=1 PF00517//PF00963//PF04799//PF07352//PF00957 Retroviral envelope protein//Cohesin domain//fzo-like conserved region//Bacteriophage Mu Gam like protein//Synaptobrevin GO:0008053//GO:0000272//GO:0042262//GO:0016192 mitochondrial fusion//polysaccharide catabolic process//DNA protection//vesicle-mediated transport GO:0030246//GO:0003690//GO:0005198//GO:0003924 carbohydrate binding//double-stranded DNA binding//structural molecule activity//GTPase activity GO:0005741//GO:0016021//GO:0019031 mitochondrial outer membrane//integral component of membrane//viral envelope KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.46203 BP_3 1.00 0.34 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46204 BP_3 107.12 1.86 3063 642910620 XP_008200030.1 353 2.3e-30 PREDICTED: uncharacterized protein LOC100142225 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.46205 BP_3 55.33 1.18 2558 642929465 XP_974907.2 1071 1.1e-113 PREDICTED: armadillo repeat-containing protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K486 693 3.0e-71 Armadillo repeat-containing protein 6 homolog OS=Drosophila melanogaster GN=CG5721 PE=1 SV=1 PF00514//PF15785 Armadillo/beta-catenin-like repeat//Serine/threonine-protein kinase smg-1 GO:0016310//GO:0000184//GO:0009069 phosphorylation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//serine family amino acid metabolic process GO:0005515//GO:0004674 protein binding//protein serine/threonine kinase activity -- -- KOG4199 Uncharacterized conserved protein Cluster-8309.46206 BP_3 122.26 1.41 4467 91088115 XP_969791.1 1930 4.6e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 4.4e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF04851//PF01105 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//emp24/gp25L/p24 family/GOLD GO:0006810 transport GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0008026 ATP binding//nucleic acid binding//DNA binding//hydrolase activity//ATP-dependent helicase activity GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.46208 BP_3 52.23 0.69 3916 642925647 XP_008194654.1 4485 0.0e+00 PREDICTED: potassium voltage-gated channel subfamily H member 6-like isoform X2 [Tribolium castaneum] 642925646 XM_008196432.1 572 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel subfamily H member 6-like (LOC662676), transcript variant X2, mRNA K04910 KCNH7 potassium voltage-gated channel Eag-related subfamily H member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04910 Q9NS40 1865 5.8e-207 Potassium voltage-gated channel subfamily H member 7 OS=Homo sapiens GN=KCNH7 PE=2 SV=2 PF08447//PF00520//PF00989 PAS fold//Ion transport protein//PAS fold GO:0006811//GO:0055085//GO:0006355 ion transport//transmembrane transport//regulation of transcription, DNA-templated GO:0005515//GO:0005216 protein binding//ion channel activity GO:0016020 membrane KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain Cluster-8309.46209 BP_3 186.69 2.74 3578 642922915 XP_008200450.1 3937 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X1 [Tribolium castaneum]>gi|270006550|gb|EFA02998.1| hypothetical protein TcasGA2_TC010420 [Tribolium castaneum] 642922916 XM_008202229.1 385 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5F499 2444 3.8e-274 Dynamin-like 120 kDa protein, mitochondrial OS=Gallus gallus GN=OPA1 PE=2 SV=1 PF08477//PF06305//PF01926//PF13304//PF02421//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function (DUF1049)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ferrous iron transport protein B//Ras family GO:0006184//GO:0015684//GO:0007264 obsolete GTP catabolic process//ferrous iron transport//small GTPase mediated signal transduction GO:0005524//GO:0015093//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//GTP binding GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.4621 BP_3 6.00 0.51 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46211 BP_3 520.93 6.07 4425 91093481 XP_968172.1 1641 1.5e-179 PREDICTED: WD repeat domain phosphoinositide-interacting protein 3 [Tribolium castaneum]>gi|270012665|gb|EFA09113.1| hypothetical protein TcasGA2_TC015973 [Tribolium castaneum] 766932181 XM_011500000.1 121 1.09625e-53 PREDICTED: Ceratosolen solmsi marchali WD repeat domain phosphoinositide-interacting protein 3 (LOC105362539), mRNA -- -- -- -- Q9CR39 1375 4.3e-150 WD repeat domain phosphoinositide-interacting protein 3 OS=Mus musculus GN=Wdr45b PE=2 SV=2 PF04584//PF00240//PF14560//PF03178//PF00400 Poxvirus A28 family//Ubiquitin family//Ubiquitin-like domain//CPSF A subunit region//WD domain, G-beta repeat GO:0016032 viral process GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0019031//GO:0005634 viral envelope//nucleus KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.46213 BP_3 20550.57 297.07 3626 642940390 XP_008200542.1 2165 2.1e-240 PREDICTED: chitin deacetylase 5 isoform X3 [Tribolium castaneum] 827560342 XM_012695639.1 311 2.14893e-159 PREDICTED: Bombyx mori uncharacterized LOC101740429 (LOC101740429), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0006030//GO:0006807//GO:0005975 chitin metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.46217 BP_3 81.92 0.44 9259 642936835 XP_008197838.1 1310 7.5e-141 PREDICTED: calcium-activated potassium channel slowpoke isoform X2 [Tribolium castaneum] 642936834 XM_008199616.1 411 0 PREDICTED: Tribolium castaneum calcium-activated potassium channel slowpoke (LOC657078), transcript variant X2, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1258 3.3e-136 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF03493//PF02254//PF01478//PF00520//PF13606//PF07503 Calcium-activated BK potassium channel alpha subunit//TrkA-N domain//Type IV leader peptidase family//Ion transport protein//Ankyrin repeat//HypF finger GO:0055085//GO:0006813//GO:0006811 transmembrane transport//potassium ion transport//ion transport GO:0004190//GO:0015269//GO:0005515//GO:0005216//GO:0008270 aspartic-type endopeptidase activity//calcium-activated potassium channel activity//protein binding//ion channel activity//zinc ion binding GO:0016020 membrane KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.46218 BP_3 141.47 1.54 4711 157138068 XP_001657222.1 1584 6.5e-173 AAEL003765-PA, partial [Aedes aegypti]>gi|108880706|gb|EAT44931.1| AAEL003765-PA, partial [Aedes aegypti] 642936834 XM_008199616.1 461 0 PREDICTED: Tribolium castaneum calcium-activated potassium channel slowpoke (LOC657078), transcript variant X2, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1492 1.2e-163 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF07503//PF03493 HypF finger//Calcium-activated BK potassium channel alpha subunit GO:0006813 potassium ion transport GO:0000166//GO:0008270//GO:0060072//GO:0015269 nucleotide binding//zinc ion binding//large conductance calcium-activated potassium channel activity//calcium-activated potassium channel activity GO:0016020 membrane KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.46220 BP_3 9.00 2.90 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46221 BP_3 57.61 1.76 1874 815819889 XP_012231138.1 1373 7.5e-149 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X4 [Linepithema humile] 642930305 XM_008198117.1 695 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 Q9UL51 591 1.5e-59 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens GN=HCN2 PE=1 SV=3 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.46225 BP_3 159.00 12.10 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46226 BP_3 73.65 1.15 3381 189234485 XP_001811926.1 1005 6.4e-106 PREDICTED: uncharacterized protein LOC100142275 isoform X2 [Tribolium castaneum]>gi|270001729|gb|EEZ98176.1| hypothetical protein TcasGA2_TC000605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335//PF02747 Tetraspanin family//Proliferating cell nuclear antigen, C-terminal domain GO:0006275 regulation of DNA replication GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.46227 BP_3 141.23 3.48 2250 642911000 XP_008193502.1 361 2.0e-31 PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum]>gi|642911002|ref|XP_008193503.1| PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16113 Enoyl-CoA hydratase/isomerase -- -- GO:0016836 hydro-lyase activity -- -- -- -- Cluster-8309.46228 BP_3 115.93 2.03 3038 642913496 XP_008201037.1 1087 1.8e-115 PREDICTED: uncharacterized protein LOC100142275 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4623 BP_3 26.00 2.73 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46230 BP_3 106.75 1.83 3105 189238048 XP_001811309.1 1728 8.5e-190 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 2.2e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF03015//PF01073//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0080019//GO:0016616//GO:0003854//GO:0050662//GO:0003824 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.46232 BP_3 30.72 0.48 3347 642914719 XP_008190322.1 390 1.3e-34 PREDICTED: pH-sensitive chloride channel isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13443//PF02932 Cro/C1-type HTH DNA-binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport GO:0043565 sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.46233 BP_3 1926.26 26.52 3792 189237166 XP_974303.2 1329 1.9e-143 PREDICTED: transmembrane protein 198 isoform X1 [Tribolium castaneum]>gi|270007195|gb|EFA03643.1| hypothetical protein TcasGA2_TC013737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q498W5 483 1.0e-46 Transmembrane protein 198-B OS=Danio rerio GN=tmem198b PE=2 SV=1 PF09207//PF05365 Yeast killer toxin//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0009405//GO:0006122//GO:0008219 pathogenesis//mitochondrial electron transport, ubiquinol to cytochrome c//cell death -- -- GO:0005750//GO:0005576//GO:0005743 mitochondrial respiratory chain complex III//extracellular region//mitochondrial inner membrane -- -- Cluster-8309.46235 BP_3 2.00 2.64 316 780114121 XP_011676955.1 200 1.3e-13 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q9J569 159 3.1e-10 Putative ankyrin repeat protein FPV162 OS=Fowlpox virus (strain NVSL) GN=FPV162 PE=3 SV=1 PF13606//PF00023//PF05396 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- -- -- Cluster-8309.46236 BP_3 5.00 5.14 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46237 BP_3 2.00 1.73 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46238 BP_3 39.98 0.62 3375 765336429 XP_011493101.1 255 5.9e-19 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 222 1.6e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.46239 BP_3 14.87 3.16 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4624 BP_3 106.00 1.59 3495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46240 BP_3 70.84 1.09 3431 765336429 XP_011493101.1 255 6.0e-19 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 222 1.7e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.46241 BP_3 2.00 0.87 401 307181085 EFN68830.1 155 2.8e-08 Transient receptor potential channel pyrexia [Camponotus floridanus] -- -- -- -- -- -- -- -- -- O14974 147 9.6e-09 Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens GN=PPP1R12A PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.46242 BP_3 22.57 0.67 1924 642914102 XP_008201543.1 1515 2.6e-165 PREDICTED: ras-interacting protein RIP3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.46244 BP_3 7.22 0.71 782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46247 BP_3 535.15 11.00 2637 478251138 ENN71614.1 1171 2.8e-125 hypothetical protein YQE_11713, partial [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q91XA9 609 1.7e-61 Acidic mammalian chitinase OS=Mus musculus GN=Chia PE=1 SV=2 PF00287//PF00704 Sodium / potassium ATPase beta chain//Glycosyl hydrolases family 18 GO:0006814//GO:0006813//GO:0005975 sodium ion transport//potassium ion transport//carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.46248 BP_3 511.91 2.49 10217 642937160 XP_969386.2 1135 1.6e-120 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] 242018355 XM_002429598.1 78 2.03575e-29 Pediculus humanus corporis Prolyl 4-hydroxylase alpha-1 subunit precursor, putative, mRNA K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 P13674 833 7.0e-87 Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens GN=P4HA1 PE=1 SV=2 PF13640//PF08476//PF08336//PF03171 2OG-Fe(II) oxygenase superfamily//Viral D10 N-terminal//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//2OG-Fe(II) oxygenase superfamily GO:0055114//GO:0006560//GO:0018401//GO:0006525 oxidation-reduction process//proline metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process GO:0016491//GO:0016791//GO:0016702//GO:0004656 oxidoreductase activity//phosphatase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//procollagen-proline 4-dioxygenase activity GO:0005783 endoplasmic reticulum KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.46249 BP_3 1.24 1.43 323 642930494 XP_008196427.1 461 7.3e-44 PREDICTED: CLIP-associating protein isoform X2 [Tribolium castaneum]>gi|270009386|gb|EFA05834.1| hypothetical protein TcasGA2_TC008618 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q9NBD7 274 1.5e-23 CLIP-associating protein OS=Drosophila melanogaster GN=chb PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46251 BP_3 516.38 3.69 7044 642930498 XP_008196429.1 2853 0.0e+00 PREDICTED: CLIP-associating protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 946 3.8e-100 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF12844//PF01528//PF11640//PF02985 Helix-turn-helix domain//Herpesvirus glycoprotein M//Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0004674//GO:0043565 protein binding//protein serine/threonine kinase activity//sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.46252 BP_3 1634.35 10.70 7652 91089099 XP_971819.1 9261 0.0e+00 PREDICTED: serine/threonine-protein kinase mTOR [Tribolium castaneum]>gi|270011516|gb|EFA07964.1| hypothetical protein TcasGA2_TC005546 [Tribolium castaneum] 242011951 XM_002426662.1 83 2.53024e-32 Pediculus humanus corporis Phosphatidylinositol 3-kinase tor2, putative, mRNA K07203 FRAP FKBP12-rapamycin complex-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K07203 Q9VK45 6979 0.0e+00 Target of rapamycin OS=Drosophila melanogaster GN=Tor PE=1 SV=1 PF00454//PF01602//PF13176//PF02260//PF08771//PF02985//PF02259 Phosphatidylinositol 3- and 4-kinase//Adaptin N terminal region//Tetratricopeptide repeat//FATC domain//Rapamycin binding domain//HEAT repeat//FAT domain GO:0016192//GO:0006886//GO:0016310 vesicle-mediated transport//intracellular protein transport//phosphorylation GO:0016773//GO:0016301//GO:0005524//GO:0008144//GO:0005515 phosphotransferase activity, alcohol group as acceptor//kinase activity//ATP binding//drug binding//protein binding GO:0030117 membrane coat KOG0891 DNA-dependent protein kinase Cluster-8309.46253 BP_3 93.50 0.61 7730 91089099 XP_971819.1 9229 0.0e+00 PREDICTED: serine/threonine-protein kinase mTOR [Tribolium castaneum]>gi|270011516|gb|EFA07964.1| hypothetical protein TcasGA2_TC005546 [Tribolium castaneum] 242011951 XM_002426662.1 74 2.57431e-27 Pediculus humanus corporis Phosphatidylinositol 3-kinase tor2, putative, mRNA K07203 FRAP FKBP12-rapamycin complex-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K07203 Q9VK45 6944 0.0e+00 Target of rapamycin OS=Drosophila melanogaster GN=Tor PE=1 SV=1 PF02985//PF02259//PF00454//PF13176//PF01602//PF02260//PF08771 HEAT repeat//FAT domain//Phosphatidylinositol 3- and 4-kinase//Tetratricopeptide repeat//Adaptin N terminal region//FATC domain//Rapamycin binding domain GO:0016192//GO:0006886//GO:0016310 vesicle-mediated transport//intracellular protein transport//phosphorylation GO:0016301//GO:0016773//GO:0005524//GO:0005515//GO:0008144 kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding//protein binding//drug binding GO:0030117 membrane coat KOG0891 DNA-dependent protein kinase Cluster-8309.46256 BP_3 159.92 2.30 3649 91087023 XP_974255.1 1236 1.1e-132 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q9C0D9 679 1.8e-69 Ethanolaminephosphotransferase 1 OS=Homo sapiens GN=EPT1 PE=1 SV=3 PF13292 1-deoxy-D-xylulose-5-phosphate synthase GO:0006694//GO:0016114 steroid biosynthetic process//terpenoid biosynthetic process GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.46257 BP_3 116.07 1.86 3303 91087023 XP_974255.1 1159 8.7e-124 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q80TA1 585 1.3e-58 Ethanolaminephosphotransferase 1 OS=Mus musculus GN=Ept1 PE=2 SV=3 PF13292//PF07645 1-deoxy-D-xylulose-5-phosphate synthase//Calcium-binding EGF domain GO:0016114//GO:0006694 terpenoid biosynthetic process//steroid biosynthetic process GO:0008661//GO:0005509 1-deoxy-D-xylulose-5-phosphate synthase activity//calcium ion binding -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.46259 BP_3 135.98 4.14 1875 642910713 XP_008200528.1 263 3.9e-20 PREDICTED: serine-arginine protein 55-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 Q08170 243 3.3e-19 Serine/arginine-rich splicing factor 4 OS=Homo sapiens GN=SRSF4 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.4626 BP_3 155.88 4.98 1801 91076116 XP_969524.1 1541 2.4e-168 PREDICTED: tRNA modification GTPase GTPBP3, mitochondrial [Tribolium castaneum]>gi|270014577|gb|EFA11025.1| hypothetical protein TcasGA2_TC004613 [Tribolium castaneum] -- -- -- -- -- K03650 mnmE, trmE, MSS1 tRNA modification GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K03650 Q501Z5 1094 6.7e-118 tRNA modification GTPase GTPBP3, mitochondrial OS=Danio rerio GN=gtpbp3 PE=2 SV=1 PF02421//PF00071//PF00005//PF03193//PF08477//PF01926 Ferrous iron transport protein B//Ras family//ABC transporter//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0008033//GO:0015684//GO:0007264 tRNA processing//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0015093//GO:0005524//GO:0016887//GO:0005525//GO:0000166 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//ATPase activity//GTP binding//nucleotide binding GO:0016021 integral component of membrane KOG1191 Mitochondrial GTPase Cluster-8309.46260 BP_3 1102.79 14.20 4034 642935257 XP_008197935.1 2067 5.4e-229 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NRG5 1325 2.5e-144 NADPH-dependent diflavin oxidoreductase 1 OS=Xenopus laevis GN=ndor1 PE=2 SV=1 PF12641//PF00175//PF01344//PF07646//PF00667//PF00258 Flavodoxin domain//Oxidoreductase NAD-binding domain//Kelch motif//Kelch motif//FAD binding domain//Flavodoxin GO:0055114 oxidation-reduction process GO:0005515//GO:0016491//GO:0010181 protein binding//oxidoreductase activity//FMN binding -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.46262 BP_3 403.83 11.97 1918 642931467 XP_966826.3 1593 2.4e-174 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q05B81 249 6.9e-20 Proton-coupled folate transporter OS=Bos taurus GN=SLC46A1 PE=2 SV=1 PF05026//PF07690 Dcp2, box A domain//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0016787//GO:0003723//GO:0030145 hydrolase activity//RNA binding//manganese ion binding GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.46263 BP_3 42.00 3.21 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46264 BP_3 1747.90 14.06 6285 270005549 EFA01997.1 4656 0.0e+00 hypothetical protein TcasGA2_TC007618 [Tribolium castaneum] 642919307 XM_008193597.1 101 2.04686e-42 PREDICTED: Tribolium castaneum signal-induced proliferation-associated 1-like protein 2 (LOC660473), transcript variant X2, mRNA K17702 SIPA1L2, SPAL2 signal-induced proliferation-associated 1 like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17702 Q80TE4 1803 1.4e-199 Signal-induced proliferation-associated 1-like protein 2 OS=Mus musculus GN=Sipa1l2 PE=1 SV=3 PF06005//PF00595//PF04799//PF02145//PF06221 Protein of unknown function (DUF904)//PDZ domain (Also known as DHR or GLGF)//fzo-like conserved region//Rap/ran-GAP//Putative zinc finger motif, C2HC5-type GO:0006355//GO:0008053//GO:0051056//GO:0000917//GO:0043093 regulation of transcription, DNA-templated//mitochondrial fusion//regulation of small GTPase mediated signal transduction//barrier septum assembly//FtsZ-dependent cytokinesis GO:0005096//GO:0003924//GO:0005515//GO:0008270 GTPase activator activity//GTPase activity//protein binding//zinc ion binding GO:0005634//GO:0016021//GO:0005741//GO:0005737 nucleus//integral component of membrane//mitochondrial outer membrane//cytoplasm KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46268 BP_3 19.00 3.26 573 91091214 XP_966756.1 368 7.9e-33 PREDICTED: WD repeat-containing protein 24 [Tribolium castaneum]>gi|270014105|gb|EFA10553.1| hypothetical protein TcasGA2_TC012809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZX22 179 2.7e-12 WD repeat-containing protein 24 OS=Xenopus laevis GN=wdr24 PE=2 SV=1 -- -- GO:0016558//GO:0007165 protein import into peroxisome matrix//signal transduction GO:0005053 peroxisome matrix targeting signal-2 binding GO:0005781//GO:0005777 obsolete peroxisome targeting signal receptor complex//peroxisome -- -- Cluster-8309.46269 BP_3 24.05 0.57 2325 642920861 XP_008192589.1 2705 3.3e-303 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 780702434 XM_011704077.1 464 0 PREDICTED: Wasmannia auropunctata protein turtle (LOC105458610), mRNA -- -- -- -- Q967D7 2350 2.0e-263 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF13895//PF07354//PF00041//PF16656 Tissue factor//Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0007339//GO:0019497 riboflavin metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.46271 BP_3 1.00 1.14 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46272 BP_3 62.00 2.33 1572 478252882 ENN73270.1 1041 2.0e-110 hypothetical protein YQE_10113, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46274 BP_3 1125.58 33.86 1894 642939755 XP_969161.2 2023 3.2e-224 PREDICTED: dnaJ homolog subfamily C member 3 [Tribolium castaneum] -- -- -- -- -- K09523 DNAJC3 DnaJ homolog subfamily C member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09523 Q13217 1117 1.5e-120 DnaJ homolog subfamily C member 3 OS=Homo sapiens GN=DNAJC3 PE=1 SV=1 PF07378//PF13181//PF13174//PF13371//PF00515//PF00836//PF13414//PF13176 Flagellar protein FlbT//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Stathmin family//TPR repeat//Tetratricopeptide repeat GO:0031110//GO:0006402//GO:1902209 regulation of microtubule polymerization or depolymerization//mRNA catabolic process//negative regulation of bacterial-type flagellum assembly GO:0048027//GO:0005515 mRNA 5'-UTR binding//protein binding -- -- KOG0550 Molecular chaperone (DnaJ superfamily) Cluster-8309.46275 BP_3 7.00 0.43 1074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46278 BP_3 24.42 0.57 2374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46279 BP_3 392.24 5.41 3784 642919263 XP_008191800.1 2096 2.2e-232 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGM5 1006 2.3e-107 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.46280 BP_3 36.73 0.46 4167 91088223 XP_973543.1 1516 4.4e-165 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X1 [Tribolium castaneum]>gi|270011823|gb|EFA08271.1| hypothetical protein TcasGA2_TC005902 [Tribolium castaneum] 645002819 XM_008209794.1 206 5.78577e-101 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X3, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 1276 1.2e-138 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.46281 BP_3 154.90 3.64 2345 91088223 XP_973543.1 1516 2.5e-165 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X1 [Tribolium castaneum]>gi|270011823|gb|EFA08271.1| hypothetical protein TcasGA2_TC005902 [Tribolium castaneum] 645002819 XM_008209794.1 206 3.23634e-101 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X3, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 1276 6.9e-139 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.46282 BP_3 4.12 0.41 782 642931814 XP_008196744.1 595 5.1e-59 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q9VG82 369 3.4e-34 Probable cytochrome P450 9f2 OS=Drosophila melanogaster GN=Cyp9f2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.46283 BP_3 89.87 2.16 2298 478256087 ENN76286.1 2279 8.1e-254 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 1431 7.1e-157 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF02568//PF00764//PF00733 Thiamine biosynthesis protein (ThiI)//Arginosuccinate synthase//Asparagine synthase GO:0006522//GO:0008033//GO:0006526//GO:0006529//GO:0006531//GO:0006560 alanine metabolic process//tRNA processing//arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process GO:0004066//GO:0004810//GO:0005524//GO:0004055 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity//ATP binding//argininosuccinate synthase activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.46285 BP_3 72.00 8.14 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46287 BP_3 35.06 0.33 5464 642915951 XP_008190823.1 974 4.1e-102 PREDICTED: protein halfway isoform X2 [Tribolium castaneum]>gi|270004091|gb|EFA00539.1| hypothetical protein TcasGA2_TC003404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 475 1.2e-45 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46288 BP_3 187.17 5.18 2033 642927423 XP_008195266.1 686 3.8e-69 PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum]>gi|642927425|ref|XP_008195267.1| PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46289 BP_3 12.11 0.52 1417 270009582 EFA06030.1 346 7.0e-30 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4629 BP_3 7.63 0.88 709 91076116 XP_969524.1 278 2.7e-22 PREDICTED: tRNA modification GTPase GTPBP3, mitochondrial [Tribolium castaneum]>gi|270014577|gb|EFA11025.1| hypothetical protein TcasGA2_TC004613 [Tribolium castaneum] -- -- -- -- -- K03650 mnmE, trmE, MSS1 tRNA modification GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K03650 Q969Y2 180 2.5e-12 tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens GN=GTPBP3 PE=1 SV=2 -- -- GO:0008033 tRNA processing GO:0000166 nucleotide binding -- -- -- -- Cluster-8309.46290 BP_3 1739.69 16.22 5461 270009582 EFA06030.1 3206 0.0e+00 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] 749781041 XM_011146561.1 110 1.76527e-47 PREDICTED: Harpegnathos saltator uncharacterized LOC105186395 (LOC105186395), mRNA K05725 PTK2, FAK focal adhesion kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05725 Q05397 1803 1.2e-199 Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2 PF07714//PF03623//PF00069 Protein tyrosine kinase//Focal adhesion targeting region//Protein kinase domain GO:0006468//GO:0007172//GO:0007165 protein phosphorylation//signal complex assembly//signal transduction GO:0004713//GO:0005524//GO:0004672//GO:0004871 protein tyrosine kinase activity//ATP binding//protein kinase activity//signal transducer activity GO:0005925 focal adhesion KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain Cluster-8309.46291 BP_3 7.14 0.35 1285 170036200 XP_001845953.1 270 4.1e-21 conserved hypothetical protein [Culex quinquefasciatus]>gi|167878751|gb|EDS42134.1| conserved hypothetical protein [Culex quinquefasciatus] 543382501 XM_005534384.1 41 9.25436e-10 PREDICTED: Pseudopodoces humilis bromodomain containing 2 (BRD2), mRNA K08871 BRD2 bromodomain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08871 P13709 249 4.6e-20 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1474 Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins Cluster-8309.46293 BP_3 16.20 0.62 1560 642914933 XP_008190447.1 345 1.0e-29 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.46294 BP_3 1128.63 19.02 3152 642914935 XP_008190448.1 756 4.4e-77 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X2 [Tribolium castaneum] 170050238 XM_001859888.1 68 2.25777e-24 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46295 BP_3 18.60 1.35 955 642914933 XP_008190447.1 457 6.3e-43 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X1 [Tribolium castaneum] 170050238 XM_001859888.1 68 6.67752e-25 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46296 BP_3 1125.05 13.85 4207 751778641 XP_011198371.1 1054 1.7e-111 PREDICTED: REST corepressor isoform X2 [Bactrocera dorsalis] 817199620 XM_012420083.1 130 1.03446e-58 PREDICTED: Orussus abietinus uncharacterized LOC105697085 (LOC105697085), transcript variant X3, mRNA -- -- -- -- Q59E36 855 8.1e-90 REST corepressor OS=Drosophila melanogaster GN=CoRest PE=1 SV=2 PF00376 MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG1194 Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains Cluster-8309.46298 BP_3 896.00 11.90 3920 91076686 XP_971385.1 1175 1.4e-125 PREDICTED: dnaJ homolog subfamily C member 25 homolog [Tribolium castaneum]>gi|270001878|gb|EEZ98325.1| hypothetical protein TcasGA2_TC000779 [Tribolium castaneum] -- -- -- -- -- K19371 DNAJC25 DnaJ homolog subfamily C member 25 http://www.genome.jp/dbget-bin/www_bget?ko:K19371 Q9VXT2 979 3.2e-104 DnaJ homolog subfamily C member 25 homolog OS=Drosophila melanogaster GN=CG7872 PE=2 SV=1 PF05746//PF02854 DALR anticodon binding domain//MIF4G domain GO:0006420//GO:0006560//GO:0006457//GO:0006525 arginyl-tRNA aminoacylation//proline metabolic process//protein folding//arginine metabolic process GO:0051082//GO:0005515//GO:0004814//GO:0031072//GO:0005524//GO:0003723 unfolded protein binding//protein binding//arginine-tRNA ligase activity//heat shock protein binding//ATP binding//RNA binding -- -- KOG0722 Molecular chaperone (DnaJ superfamily) Cluster-8309.46299 BP_3 77.71 0.59 6644 91086487 XP_970606.1 1009 4.3e-106 PREDICTED: putative Rab-43-like protein ENSP00000330714 [Tribolium castaneum]>gi|270009806|gb|EFA06254.1| hypothetical protein TcasGA2_TC009113 [Tribolium castaneum] -- -- -- -- -- K07930 RAB43 Ras-related protein Rab-43 http://www.genome.jp/dbget-bin/www_bget?ko:K07930 Q86YS6 601 3.6e-60 Ras-related protein Rab-43 OS=Homo sapiens GN=RAB43 PE=1 SV=1 PF08710//PF08513//PF01926//PF08477//PF14991//PF00025//PF00096//PF02367//PF04670//PF10662//PF00071 nsp9 replicase//LisH//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein melan-A//ADP-ribosylation factor family//Zinc finger, C2H2 type//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family GO:0015031//GO:0007264//GO:0002949//GO:0006576//GO:0019079 protein transport//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//cellular biogenic amine metabolic process//viral genome replication GO:0046872//GO:0005525//GO:0005515//GO:0005524//GO:0003723 metal ion binding//GTP binding//protein binding//ATP binding//RNA binding GO:0042470 melanosome KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.46300 BP_3 1014.51 9.75 5307 91081967 XP_967820.1 2574 1.2e-287 PREDICTED: replication factor C subunit 1 [Tribolium castaneum]>gi|270007366|gb|EFA03814.1| hypothetical protein TcasGA2_TC013927 [Tribolium castaneum] 196009296 XM_002114478.1 41 3.90116e-09 Trichoplax adhaerens hypothetical protein, mRNA K10754 RFC1 replication factor C subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10754 P35600 1845 1.6e-204 Replication factor C subunit 1 OS=Drosophila melanogaster GN=Gnf1 PE=1 SV=2 PF00004//PF03462//PF06144//PF07728//PF05496//PF08519//PF00910//PF00472//PF06414 ATPase family associated with various cellular activities (AAA)//PCRF domain//DNA polymerase III, delta subunit//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Replication factor RFC1 C terminal domain//RNA helicase//RF-1 domain//Zeta toxin GO:0006281//GO:0006415//GO:0006260//GO:0006449//GO:0006310 DNA repair//translational termination//DNA replication//regulation of translational termination//DNA recombination GO:0005524//GO:0003747//GO:0003689//GO:0016301//GO:1901363//GO:0016887//GO:0003723//GO:0003677//GO:0016149//GO:0003887//GO:0097159//GO:0009378//GO:0003724 ATP binding//translation release factor activity//DNA clamp loader activity//kinase activity//heterocyclic compound binding//ATPase activity//RNA binding//DNA binding//translation release factor activity, codon specific//DNA-directed DNA polymerase activity//organic cyclic compound binding//four-way junction helicase activity//RNA helicase activity GO:0009360//GO:0009379//GO:0005663//GO:0042575//GO:0005840//GO:0018444//GO:0005737//GO:0005657 DNA polymerase III complex//Holliday junction helicase complex//DNA replication factor C complex//DNA polymerase complex//ribosome//translation release factor complex//cytoplasm//replication fork KOG1968 Replication factor C, subunit RFC1 (large subunit) Cluster-8309.46301 BP_3 38.49 0.36 5376 91081967 XP_967820.1 2376 1.1e-264 PREDICTED: replication factor C subunit 1 [Tribolium castaneum]>gi|270007366|gb|EFA03814.1| hypothetical protein TcasGA2_TC013927 [Tribolium castaneum] 196009296 XM_002114478.1 41 3.95222e-09 Trichoplax adhaerens hypothetical protein, mRNA K10754 RFC1 replication factor C subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10754 P35600 1821 1.0e-201 Replication factor C subunit 1 OS=Drosophila melanogaster GN=Gnf1 PE=1 SV=2 PF07728//PF03700//PF06068//PF05496//PF00004//PF03462//PF06144//PF00472//PF06414//PF08519//PF00910 AAA domain (dynein-related subfamily)//Sorting nexin, N-terminal domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//ATPase family associated with various cellular activities (AAA)//PCRF domain//DNA polymerase III, delta subunit//RF-1 domain//Zeta toxin//Replication factor RFC1 C terminal domain//RNA helicase GO:0006415//GO:0006260//GO:0006281//GO:0006886//GO:0006310//GO:0006449 translational termination//DNA replication//DNA repair//intracellular protein transport//DNA recombination//regulation of translational termination GO:0016887//GO:0016301//GO:0003689//GO:0000166//GO:0003747//GO:0005524//GO:0003724//GO:0009378//GO:0017111//GO:0003887//GO:0016149//GO:0003677//GO:0003723//GO:0003678 ATPase activity//kinase activity//DNA clamp loader activity//nucleotide binding//translation release factor activity//ATP binding//RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//DNA-directed DNA polymerase activity//translation release factor activity, codon specific//DNA binding//RNA binding//DNA helicase activity GO:0005737//GO:0018444//GO:0005840//GO:0042575//GO:0005663//GO:0009379//GO:0009360//GO:0005657 cytoplasm//translation release factor complex//ribosome//DNA polymerase complex//DNA replication factor C complex//Holliday junction helicase complex//DNA polymerase III complex//replication fork KOG1968 Replication factor C, subunit RFC1 (large subunit) Cluster-8309.46302 BP_3 25.17 0.69 2049 270003204 EEZ99651.1 607 5.5e-60 hypothetical protein TcasGA2_TC002408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G3MWR8 373 3.1e-34 Protein-methionine sulfoxide oxidase MICAL3 OS=Bos taurus GN=MICAL3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46303 BP_3 227.00 6.23 2047 270003204 EEZ99651.1 1245 5.7e-134 hypothetical protein TcasGA2_TC002408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86BA1 496 1.7e-48 Protein-methionine sulfoxide oxidase Mical OS=Drosophila melanogaster GN=Mical PE=1 SV=1 PF06467//PF00412 MYM-type Zinc finger with FCS sequence motif//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.46304 BP_3 39.83 1.03 2164 270003204 EEZ99651.1 607 5.8e-60 hypothetical protein TcasGA2_TC002408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G3MWR8 373 3.2e-34 Protein-methionine sulfoxide oxidase MICAL3 OS=Bos taurus GN=MICAL3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46305 BP_3 44.00 11.43 477 642918586 XP_008199372.1 162 5.1e-09 PREDICTED: protein-methionine sulfoxide oxidase Mical [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46307 BP_3 992.47 7.06 7066 642919794 XP_008192070.1 2788 0.0e+00 PREDICTED: coronin-7 isoform X1 [Tribolium castaneum]>gi|270005922|gb|EFA02370.1| hypothetical protein TcasGA2_TC008045 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1118 4.3e-120 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF04851//PF00400 Type III restriction enzyme, res subunit//WD domain, G-beta repeat -- -- GO:0005515//GO:0003677//GO:0016787//GO:0005524 protein binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.46308 BP_3 8.19 0.38 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46311 BP_3 218.00 8.70 1500 270015441 EFA11889.1 189 1.2e-11 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03079 ARD/ARD' family GO:0055114 oxidation-reduction process GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity -- -- -- -- Cluster-8309.46312 BP_3 90.07 0.94 4893 91088253 XP_966567.1 1655 3.9e-181 PREDICTED: ankyrin repeat and zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270012152|gb|EFA08600.1| hypothetical protein TcasGA2_TC006259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPJ0 627 2.6e-63 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF15306//PF13606//PF06072//PF00023//PF01553 LIN37//Ankyrin repeat//Alphaherpesvirus tegument protein US9//Ankyrin repeat//Acyltransferase GO:0007049//GO:0008152 cell cycle//metabolic process GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0017053//GO:0019033 transcriptional repressor complex//viral tegument KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.46313 BP_3 172.00 1.59 5491 642929086 XP_008195685.1 2031 1.1e-224 PREDICTED: putative transcription factor SOX-15 isoform X1 [Tribolium castaneum] 642929087 XM_008197464.1 219 4.53357e-108 PREDICTED: Tribolium castaneum putative transcription factor SOX-15 (LOC663052), transcript variant X2, mRNA K04495 SOX17 transcription factor SOX17 (SOX group F) http://www.genome.jp/dbget-bin/www_bget?ko:K04495 P40657 448 1.7e-42 Putative transcription factor SOX-15 OS=Drosophila melanogaster GN=Sox15 PE=2 SV=2 PF17066 RBPJ-interacting and tubulin associated protein GO:0051168//GO:0007219 nuclear export//Notch signaling pathway GO:0015631 tubulin binding GO:0045298 tubulin complex KOG0527 HMG-box transcription factor Cluster-8309.46317 BP_3 358.65 8.42 2344 270014462 EFA10910.1 282 3.0e-22 hypothetical protein TcasGA2_TC001736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46318 BP_3 1262.57 18.21 3634 642911903 XP_008199015.1 1233 2.5e-132 PREDICTED: heat shock factor protein-like isoform X3 [Tribolium castaneum] 642911902 XM_008200793.1 159 6.75341e-75 PREDICTED: Tribolium castaneum heat shock factor protein-like (LOC103314511), transcript variant X4, mRNA K09414 HSF1 heat shock transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09414 P22813 658 4.9e-67 Heat shock factor protein OS=Drosophila melanogaster GN=Hsf PE=1 SV=1 PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0627 Heat shock transcription factor Cluster-8309.46321 BP_3 286.00 11.06 1538 642925638 XP_008194650.1 1632 5.7e-179 PREDICTED: putative fatty acyl-CoA reductase CG5065 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 917 1.9e-97 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF05805//PF03015//PF01370//PF01073//PF01118 L6 membrane protein//Male sterility protein//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0080019//GO:0051287//GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding GO:0016021 integral component of membrane KOG1221 Acyl-CoA reductase Cluster-8309.46322 BP_3 255.25 1.60 7994 642920861 XP_008192589.1 3610 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 571 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3120 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF00041//PF07354//PF13895//PF02480//PF07353//PF16656 Tissue factor//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Alphaherpesvirus glycoprotein E//Uroplakin II//Purple acid Phosphatase, N-terminal domain GO:0007339//GO:0019497//GO:0061024//GO:0006771 binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//membrane organization//riboflavin metabolic process GO:0005515//GO:0003993//GO:0046872 protein binding//acid phosphatase activity//metal ion binding GO:0030176//GO:0005576//GO:0016020 integral component of endoplasmic reticulum membrane//extracellular region//membrane -- -- Cluster-8309.46323 BP_3 235.17 2.19 5465 642920861 XP_008192589.1 3667 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 663 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3167 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF02480//PF07353//PF16656//PF13895//PF07354//PF00041//PF01108 Alphaherpesvirus glycoprotein E//Uroplakin II//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Tissue factor GO:0061024//GO:0006771//GO:0007339//GO:0019497 membrane organization//riboflavin metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0005576//GO:0016020//GO:0030176 extracellular region//membrane//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.46324 BP_3 623.99 6.52 4904 642924106 XP_008194007.1 3057 0.0e+00 PREDICTED: serine/threonine-protein kinase mig-15 isoform X3 [Tribolium castaneum] 642924109 XM_008195787.1 569 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1480 3.2e-162 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF00069//PF06293//PF07463//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//NUMOD4 motif//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0016788//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//hydrolase activity, acting on ester bonds//ATP binding GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.46325 BP_3 4.59 0.60 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46327 BP_3 667.00 11.88 2999 768421086 XP_011551338.1 1409 8.1e-153 PREDICTED: E3 ubiquitin-protein ligase NRDP1 isoform X2 [Plutella xylostella] -- -- -- -- -- K11981 RNF41, NRDP1 E3 ubiquitin-protein ligase NRDP1 http://www.genome.jp/dbget-bin/www_bget?ko:K11981 Q5FWL3 1121 8.3e-121 E3 ubiquitin-protein ligase NRDP1 OS=Xenopus laevis GN=rnf41 PE=2 SV=1 PF17082//PF13639//PF15965//PF16685//PF03145//PF12861//PF02176//PF11789//PF12678//PF00367//PF04564//PF14634//PF08941//PF00097 Spindle Pole Component 29//Ring finger domain//TRAF-like zinc-finger//zinc RING finger of MSL2//Seven in absentia protein family//Anaphase-promoting complex subunit 11 RING-H2 finger//TRAF-type zinc finger//Zinc-finger of the MIZ type in Nse subunit//RING-H2 zinc finger//phosphotransferase system, EIIB//U-box domain//zinc-RING finger domain//USP8 interacting//Zinc finger, C3HC4 type (RING finger) GO:0006511//GO:0008643//GO:0007275//GO:0016567//GO:0030474 ubiquitin-dependent protein catabolic process//carbohydrate transport//multicellular organismal development//protein ubiquitination//spindle pole body duplication GO:0008270//GO:0005200//GO:0016881//GO:0031386//GO:0008982//GO:0046872//GO:0005515//GO:0004842//GO:0061630 zinc ion binding//structural constituent of cytoskeleton//acid-amino acid ligase activity//protein tag//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//metal ion binding//protein binding//ubiquitin-protein transferase activity//ubiquitin protein ligase activity GO:0009357//GO:0005823//GO:0005856//GO:0005634//GO:0005680 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//central plaque of spindle pole body//cytoskeleton//nucleus//anaphase-promoting complex -- -- Cluster-8309.46329 BP_3 262.23 4.53 3082 478255178 ENN75407.1 459 1.2e-42 hypothetical protein YQE_07958, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DAK4 165 6.1e-10 Fatty acid-binding protein 12 OS=Mus musculus GN=Fabp12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.46331 BP_3 2715.74 24.70 5591 642937261 XP_008198761.1 2852 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270001290|gb|EEZ97737.1| tartan/capricious-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12024 415 1.1e-38 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF01080//PF13855 Leucine Rich Repeat//Presenilin//Leucine rich repeat -- -- GO:0004190//GO:0005515 aspartic-type endopeptidase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.46338 BP_3 263.70 8.43 1800 642920067 XP_008192192.1 1431 1.4e-155 PREDICTED: nuclear RNA export factor 2-like [Tribolium castaneum]>gi|270005996|gb|EFA02444.1| hypothetical protein TcasGA2_TC008131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58797 434 2.3e-41 Nuclear RNA export factor 1 OS=Coturnix coturnix japonica GN=NXF1 PE=1 SV=1 PF01132//PF03943//PF09162//PF13855//PF02136 Elongation factor P (EF-P) OB domain//TAP C-terminal domain//Tap, RNA-binding//Leucine rich repeat//Nuclear transport factor 2 (NTF2) domain GO:0006414//GO:0006406//GO:0006810//GO:0006448//GO:0051028 translational elongation//mRNA export from nucleus//transport//regulation of translational elongation//mRNA transport GO:0003723//GO:0005515//GO:0003746 RNA binding//protein binding//translation elongation factor activity GO:0005634//GO:0005622//GO:0005840//GO:0005737 nucleus//intracellular//ribosome//cytoplasm -- -- Cluster-8309.46339 BP_3 53.23 0.46 5929 478262859 ENN81341.1 1820 3.5e-200 hypothetical protein YQE_02252, partial [Dendroctonus ponderosae] 213513283 NM_001141934.1 389 0 Tribolium castaneum estrogen-related receptor (Err), mRNA K08703 NR3BN, ERR estrogen-related receptor ERR http://www.genome.jp/dbget-bin/www_bget?ko:K08703 O95718 803 1.2e-83 Steroid hormone receptor ERR2 OS=Homo sapiens GN=ESRRB PE=1 SV=2 PF00105//PF01370//PF00324//PF00106//PF00104 Zinc finger, C4 type (two domains)//NAD dependent epimerase/dehydratase family//Amino acid permease//short chain dehydrogenase//Ligand-binding domain of nuclear hormone receptor GO:0008152//GO:0055085//GO:0006810//GO:0043401//GO:0006355 metabolic process//transmembrane transport//transport//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0050662//GO:0003824//GO:0016491//GO:0043565//GO:0008270//GO:0003700 coenzyme binding//catalytic activity//oxidoreductase activity//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0016020 nucleus//transcription factor complex//membrane -- -- Cluster-8309.4634 BP_3 15.68 0.36 2373 154413468 XP_001579764.1 192 8.4e-12 viral A-type inclusion protein [Trichomonas vaginalis G3]>gi|121913974|gb|EAY18778.1| viral A-type inclusion protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- A6ZYV5 162 1.0e-09 Spindle pole body component 110 OS=Saccharomyces cerevisiae (strain YJM789) GN=SPC110 PE=3 SV=1 PF08941 USP8 interacting GO:0016567 protein ubiquitination GO:0016881//GO:0031386 acid-amino acid ligase activity//protein tag -- -- -- -- Cluster-8309.46341 BP_3 657.59 6.99 4824 478250068 ENN70574.1 5312 0.0e+00 hypothetical protein YQE_12749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TDM6 588 8.5e-59 Disks large homolog 5 OS=Homo sapiens GN=DLG5 PE=1 SV=4 PF15898//PF00595//PF13180//PF04111//PF06156 cGMP-dependent protein kinase interacting domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain//Autophagy protein Apg6//Protein of unknown function (DUF972) GO:0006260//GO:0006914 DNA replication//autophagy GO:0019901//GO:0005515 protein kinase binding//protein binding -- -- KOG3580 Tight junction proteins Cluster-8309.46343 BP_3 2.74 0.40 621 642920255 XP_975582.3 303 3.0e-25 PREDICTED: pecanex-like protein 1 isoform X1 [Tribolium castaneum] 827551112 XM_012692010.1 64 7.12166e-23 PREDICTED: Bombyx mori pecanex-like protein 1 (LOC101738614), mRNA -- -- -- -- P18490 238 4.2e-19 Protein pecanex OS=Drosophila melanogaster GN=pcx PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3604 Pecanex Cluster-8309.46344 BP_3 62.65 1.17 2869 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46348 BP_3 456.35 13.58 1912 642930331 XP_008196350.1 890 7.8e-93 PREDICTED: ataxin-10 [Tribolium castaneum] -- -- -- -- -- K19323 ATXN10 ataxin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19323 P28658 312 3.4e-27 Ataxin-10 OS=Mus musculus GN=Atxn10 PE=1 SV=2 PF06743//PF01320 FAST kinase-like protein, subdomain 1//Colicin immunity protein / pyocin immunity protein GO:0006955 immune response GO:0004672//GO:0015643 protein kinase activity//toxic substance binding GO:0019814 immunoglobulin complex KOG2676 Uncharacterized conserved protein Cluster-8309.46352 BP_3 155.59 1.65 4844 91084545 XP_973071.1 1808 7.1e-199 PREDICTED: tudor domain-containing protein 7 isoform X1 [Tribolium castaneum]>gi|270008665|gb|EFA05113.1| hypothetical protein TcasGA2_TC015214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 2.1e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 PF16622 zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46354 BP_3 16.90 0.74 1395 642916805 XP_008199511.1 238 2.3e-17 PREDICTED: uncharacterized protein LOC103314681 [Tribolium castaneum]>gi|270003062|gb|EEZ99509.1| hypothetical protein TcasGA2_TC000090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05843//PF01101//PF02724//PF09726//PF05793//PF07393 Suppressor of forked protein (Suf)//HMG14 and HMG17//CDC45-like protein//Transmembrane protein//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Exocyst complex component Sec10 GO:0006270//GO:0032968//GO:0006397//GO:0006367//GO:0006887//GO:0048278 DNA replication initiation//positive regulation of transcription elongation from RNA polymerase II promoter//mRNA processing//transcription initiation from RNA polymerase II promoter//exocytosis//vesicle docking GO:0003677//GO:0031492 DNA binding//nucleosomal DNA binding GO:0016021//GO:0005634//GO:0000785//GO:0005737 integral component of membrane//nucleus//chromatin//cytoplasm -- -- Cluster-8309.46355 BP_3 16.00 5.08 443 262401269 ACY66537.1 460 1.3e-43 60S ribosomal protein L27 [Scylla paramamosain] 262401268 FJ774816.1 384 0 Scylla paramamosain 60S ribosomal protein L27 mRNA, partial cds K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 P61359 349 4.0e-32 60S ribosomal protein L27 OS=Hippocampus comes GN=rpl27 PE=2 SV=2 PF01777 Ribosomal L27e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3418 60S ribosomal protein L27 Cluster-8309.46358 BP_3 66.92 0.68 5046 642929984 XP_008196053.1 2645 6.5e-296 PREDICTED: atrial natriuretic peptide receptor 1 [Tribolium castaneum] 642929983 XM_008197831.1 317 1.38543e-162 PREDICTED: Tribolium castaneum atrial natriuretic peptide receptor 1 (LOC664507), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18910 1611 2.1e-177 Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus GN=Npr1 PE=1 SV=1 PF07701//PF06330//PF00069//PF00211//PF07714 Heme NO binding associated//Trichodiene synthase (TRI5)//Protein kinase domain//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase GO:0016106//GO:0006144//GO:0016114//GO:0006468//GO:0006182//GO:0046039//GO:0035556//GO:0009190 sesquiterpenoid biosynthetic process//purine nucleobase metabolic process//terpenoid biosynthetic process//protein phosphorylation//cGMP biosynthetic process//GTP metabolic process//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0005524//GO:0045482//GO:0004672//GO:0016849//GO:0004383 ATP binding//trichodiene synthase activity//protein kinase activity//phosphorus-oxygen lyase activity//guanylate cyclase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.46360 BP_3 33.05 0.34 5039 642937449 XP_008198840.1 454 7.4e-42 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46363 BP_3 124.19 3.34 2083 91082667 XP_966596.1 481 2.3e-45 PREDICTED: uncharacterized protein LOC659832 [Tribolium castaneum]>gi|270014970|gb|EFA11418.1| hypothetical protein TcasGA2_TC013595 [Tribolium castaneum] 642910857 XM_961503.3 132 3.92776e-60 PREDICTED: Tribolium castaneum uncharacterized LOC659832 (LOC659832), mRNA -- -- -- -- -- -- -- -- PF05808 Podoplanin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46364 BP_3 372.26 3.28 5756 91089043 XP_969794.1 4688 0.0e+00 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] 657579724 XM_008295570.1 270 2.11981e-136 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 3142 0.0e+00 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF00400//PF02985//PF06384 WD domain, G-beta repeat//HEAT repeat//Beta-catenin-interacting protein ICAT -- -- GO:0005515//GO:0008013 protein binding//beta-catenin binding GO:0016342 catenin complex KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.46365 BP_3 35.45 6.80 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46366 BP_3 69.39 0.60 5876 861611827 KMQ85369.1 365 1.8e-31 reverse transcriptase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- P21329 184 7.2e-12 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila funebris GN=jockey\pol PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46367 BP_3 48.98 0.50 5049 861611827 KMQ85369.1 365 1.6e-31 reverse transcriptase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- P21329 184 6.2e-12 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila funebris GN=jockey\pol PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46369 BP_3 13.00 3.74 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46371 BP_3 26.40 1.01 1554 91092260 XP_967199.1 670 2.1e-67 PREDICTED: uncharacterized protein C6orf136 [Tribolium castaneum]>gi|270001227|gb|EEZ97674.1| hypothetical protein TcasGA2_TC016219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SQH8 242 3.6e-19 Uncharacterized protein C6orf136 OS=Homo sapiens GN=C6orf136 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4457 Uncharacterized conserved protein Cluster-8309.46372 BP_3 12.00 6.96 372 559163445 AHB11276.1 220 7.4e-16 attacin-like immune protein [Diabrotica virgifera virgifera] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.46373 BP_3 339.00 10.85 1798 546672982 ERL84676.1 320 9.2e-27 hypothetical protein D910_02103 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5R7A8 165 3.5e-10 C-Myc-binding protein OS=Pongo abelii GN=MYCBP PE=3 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46374 BP_3 11.05 1.09 778 546672982 ERL84676.1 236 2.2e-17 hypothetical protein D910_02103 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP7 154 2.9e-09 C-Myc-binding protein OS=Bos taurus GN=MYCBP PE=3 SV=3 PF02330 Mitochondrial glycoprotein -- -- -- -- GO:0005759 mitochondrial matrix -- -- Cluster-8309.46377 BP_3 403.91 3.46 5914 91080927 XP_974039.1 6560 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3107 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF01599//PF02617//PF02207//PF04183 Ribosomal protein S27a//ATP-dependent Clp protease adaptor protein ClpS//Putative zinc finger in N-recognin (UBR box)//IucA / IucC family GO:0016567//GO:0006412//GO:0019290//GO:0006826//GO:0030163//GO:0042254 protein ubiquitination//translation//siderophore biosynthetic process//iron ion transport//protein catabolic process//ribosome biogenesis GO:0004842//GO:0008270//GO:0015343//GO:0003735 ubiquitin-protein transferase activity//zinc ion binding//siderophore transmembrane transporter activity//structural constituent of ribosome GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.46378 BP_3 282.52 1.80 7870 642934473 XP_008197678.1 5341 0.0e+00 PREDICTED: kinase D-interacting substrate of 220 kDa isoform X2 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 3.2e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF06553//PF13606//PF00023//PF00536 BNIP3//Ankyrin repeat//Ankyrin repeat//SAM domain (Sterile alpha motif) GO:0043065 positive regulation of apoptotic process GO:0005515 protein binding GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.46379 BP_3 132.96 1.11 6058 642913051 XP_008201367.1 1799 9.8e-198 PREDICTED: tRNA (guanine(10)-N2)-methyltransferase homolog [Tribolium castaneum] -- -- -- -- -- K15430 TRM11, TRMT11 tRNA (guanine10-N2)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15430 Q6YJI5 1082 5.6e-116 tRNA (guanine(10)-N2)-methyltransferase homolog OS=Gallus gallus GN=TRMT11 PE=2 SV=1 PF13181//PF02384//PF05944//PF08241//PF14863//PF01555//PF13371//PF03602//PF00515//PF02086//PF13414//PF14721 Tetratricopeptide repeat//N-6 DNA Methylase//Phage small terminase subunit//Methyltransferase domain//Alkyl sulfatase dimerisation//DNA methylase//Tetratricopeptide repeat//Conserved hypothetical protein 95//Tetratricopeptide repeat//D12 class N6 adenine-specific DNA methyltransferase//TPR repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term GO:0006306//GO:0019069//GO:0032775//GO:0008152//GO:0031167 DNA methylation//viral capsid assembly//DNA methylation on adenine//metabolic process//rRNA methylation GO:0008170//GO:0008168//GO:0009007//GO:0003677//GO:0004519//GO:0005515//GO:0046983 N-methyltransferase activity//methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//DNA binding//endonuclease activity//protein binding//protein dimerization activity -- -- KOG2671 Putative RNA methylase Cluster-8309.46381 BP_3 22.38 1.24 1161 642929593 XP_008195897.1 706 1.0e-71 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 559 4.7e-56 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0909 Peptide:N-glycanase Cluster-8309.46383 BP_3 896.93 6.85 6599 642916561 XP_008191701.1 1854 4.5e-204 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U0L2 302 1.7e-25 Ankyrin repeat domain-containing protein 33B OS=Mus musculus GN=Ankrd33b PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46384 BP_3 263.30 14.34 1177 642910330 XP_970349.3 738 2.0e-75 PREDICTED: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGE0 423 2.8e-40 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Xenopus tropicalis GN=ogfod3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46387 BP_3 51.72 0.46 5677 189240823 XP_001811917.1 3243 0.0e+00 PREDICTED: ATP-dependent RNA helicase SUV3 homolog, mitochondrial [Tribolium castaneum]>gi|270013711|gb|EFA10159.1| hypothetical protein TcasGA2_TC012348 [Tribolium castaneum] 755880618 XM_005185469.2 352 0 PREDICTED: Musca domestica ATP-dependent RNA helicase SUV3 homolog, mitochondrial (LOC101900390), mRNA K17675 SUPV3L1, SUV3 ATP-dependent RNA helicase SUPV3L1/SUV3 http://www.genome.jp/dbget-bin/www_bget?ko:K17675 Q9VN03 2690 1.8e-302 ATP-dependent RNA helicase SUV3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG9791 PE=2 SV=3 PF12513//PF11965//PF00001 Mitochondrial degradasome RNA helicase subunit C terminal//Domain of unknown function (DUF3479)//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0015994 G-protein coupled receptor signaling pathway//chlorophyll metabolic process GO:0016817//GO:0016851//GO:0003676//GO:0004930//GO:0004386//GO:0005524 hydrolase activity, acting on acid anhydrides//magnesium chelatase activity//nucleic acid binding//G-protein coupled receptor activity//helicase activity//ATP binding GO:0010007//GO:0016021 magnesium chelatase complex//integral component of membrane KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily Cluster-8309.46388 BP_3 123.89 1.06 5948 642923585 XP_008193571.1 1658 2.1e-181 PREDICTED: run domain Beclin-1 interacting and cysteine-rich containing protein [Tribolium castaneum] -- -- -- -- -- K19330 KIAA0226 run domain Beclin-1 interacting and cysteine-rich containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K19330 Q92622 802 1.6e-83 Run domain Beclin-1 interacting and cysteine-rich containing protein OS=Homo sapiens GN=KIAA0226 PE=1 SV=4 PF08506//PF14721//PF00628 Cse1//Apoptosis-inducing factor, mitochondrion-associated, C-term//PHD-finger GO:0006886 intracellular protein transport GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.46389 BP_3 138.43 1.23 5723 642923585 XP_008193571.1 1658 2.1e-181 PREDICTED: run domain Beclin-1 interacting and cysteine-rich containing protein [Tribolium castaneum] -- -- -- -- -- K19330 KIAA0226 run domain Beclin-1 interacting and cysteine-rich containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K19330 Q92622 802 1.5e-83 Run domain Beclin-1 interacting and cysteine-rich containing protein OS=Homo sapiens GN=KIAA0226 PE=1 SV=4 PF14721//PF08506//PF00628 Apoptosis-inducing factor, mitochondrion-associated, C-term//Cse1//PHD-finger GO:0006886 intracellular protein transport GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.4639 BP_3 238.51 6.94 1948 91082495 XP_972789.1 1723 2.0e-189 PREDICTED: SHC SH2 domain-binding protein 1 [Tribolium castaneum]>gi|270007137|gb|EFA03585.1| hypothetical protein TcasGA2_TC013668 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z179 296 2.5e-25 SHC SH2 domain-binding protein 1 OS=Mus musculus GN=Shcbp1 PE=1 SV=1 PF05924 SAMP Motif GO:0016055 Wnt signaling pathway GO:0008013 beta-catenin binding GO:0016342 catenin complex -- -- Cluster-8309.46391 BP_3 61.69 0.53 5945 642923585 XP_008193571.1 1658 2.1e-181 PREDICTED: run domain Beclin-1 interacting and cysteine-rich containing protein [Tribolium castaneum] -- -- -- -- -- K19330 KIAA0226 run domain Beclin-1 interacting and cysteine-rich containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K19330 Q92622 802 1.6e-83 Run domain Beclin-1 interacting and cysteine-rich containing protein OS=Homo sapiens GN=KIAA0226 PE=1 SV=4 PF08506//PF14721//PF00628 Cse1//Apoptosis-inducing factor, mitochondrion-associated, C-term//PHD-finger GO:0006886 intracellular protein transport GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.46392 BP_3 94.78 2.70 1982 270012236 EFA08684.1 705 2.3e-71 hypothetical protein TcasGA2_TC006354 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVV5 386 9.2e-36 Androgen-induced gene 1 protein OS=Homo sapiens GN=AIG1 PE=1 SV=2 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.46397 BP_3 4.00 3.56 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46399 BP_3 30.18 0.46 3474 546674389 ERL85776.1 3567 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 642926086 XM_001808290.2 513 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase TAO1 (LOC657810), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 O88664 1304 5.8e-142 Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus GN=Taok1 PE=1 SV=1 PF12474//PF00069//PF07714 Polo kinase kinase//Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.4640 BP_3 4.10 0.49 693 270007072 EFA03520.1 344 5.8e-30 hypothetical protein TcasGA2_TC013522 [Tribolium castaneum] -- -- -- -- -- K18953 NSMAF, FAN factor associated with neutral sphingomyelinase activation http://www.genome.jp/dbget-bin/www_bget?ko:K18953 -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46401 BP_3 132.58 1.48 4611 546674389 ERL85776.1 3567 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 642926086 XM_001808290.2 513 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase TAO1 (LOC657810), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 O88664 1304 7.6e-142 Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus GN=Taok1 PE=1 SV=1 PF00069//PF07714//PF12474 Protein kinase domain//Protein tyrosine kinase//Polo kinase kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.46403 BP_3 117.47 3.04 2156 270005270 EFA01718.1 1895 2.6e-209 hypothetical protein TcasGA2_TC007298 [Tribolium castaneum] 642920293 XM_008194065.1 444 0 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 9-like (LOC664510), transcript variant X2, mRNA K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 Q3U1V8 1312 4.2e-143 Mitogen-activated protein kinase kinase kinase 9 OS=Mus musculus GN=Map3k9 PE=2 SV=2 PF00018//PF14604//PF00069//PF07714 SH3 domain//Variant SH3 domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- -- -- Cluster-8309.46404 BP_3 104.19 0.63 8273 123407101 XP_001302933.1 225 4.4e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.6e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4641 BP_3 8.00 0.45 1151 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-8309.46410 BP_3 272.93 2.16 6369 642933926 XP_008197570.1 1635 1.1e-178 PREDICTED: protein Skeletor, isoforms B/C isoform X2 [Tribolium castaneum] 642933925 XM_008199348.1 310 1.36279e-158 PREDICTED: Tribolium castaneum protein Skeletor, isoforms B/C (LOC661990), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 645 2.7e-65 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.46411 BP_3 5.92 0.33 1153 270013556 EFA10004.1 292 1.0e-23 hypothetical protein TcasGA2_TC012174 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46412 BP_3 122.38 0.74 8267 642932579 XP_008196910.1 2227 3.1e-247 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 201 6.93512e-98 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q91W86 1090 8.9e-117 Vacuolar protein sorting-associated protein 11 homolog OS=Mus musculus GN=Vps11 PE=1 SV=3 PF02723//PF02148//PF12678//PF14634//PF17122//PF00097//PF00443//PF00569//PF08496//PF03194//PF12861//PF05680//PF01165//PF13639//PF00637 Non-structural protein NS3/Small envelope protein E//Zn-finger in ubiquitin-hydrolases and other protein//RING-H2 zinc finger//zinc-RING finger domain//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//Ubiquitin carboxyl-terminal hydrolase//Zinc finger, ZZ type//Peptidase family S49 N-terminal//LUC7 N_terminus//Anaphase-promoting complex subunit 11 RING-H2 finger//ATP synthase E chain//Ribosomal protein S21//Ring finger domain//Region in Clathrin and VPS GO:0015986//GO:0016567//GO:0006412//GO:0016579//GO:0015992//GO:0042254//GO:0006376//GO:0016192//GO:0006886 ATP synthesis coupled proton transport//protein ubiquitination//translation//protein deubiquitination//proton transport//ribosome biogenesis//mRNA splice site selection//vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0005515//GO:0004842//GO:0015078//GO:0008270//GO:0003735//GO:0004252//GO:0003729//GO:0036459 metal ion binding//protein binding//ubiquitin-protein transferase activity//hydrogen ion transmembrane transporter activity//zinc ion binding//structural constituent of ribosome//serine-type endopeptidase activity//mRNA binding//ubiquitinyl hydrolase activity GO:0016020//GO:0000276//GO:0005886//GO:0005680//GO:0005840//GO:0005685 membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//plasma membrane//anaphase-promoting complex//ribosome//U1 snRNP KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.46415 BP_3 508.93 1.52 16421 157124457 XP_001660469.1 11313 0.0e+00 AAEL009869-PA [Aedes aegypti]>gi|108873980|gb|EAT38205.1| AAEL009869-PA [Aedes aegypti] 665794659 XM_008546814.1 316 1.62841e-161 PREDICTED: Microplitis demolitor low-density lipoprotein receptor-related protein 2 (LOC103569491), mRNA K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 P98158 5576 0.0e+00 Low-density lipoprotein receptor-related protein 2 OS=Rattus norvegicus GN=Lrp2 PE=1 SV=1 PF00008//PF00057//PF07645//PF01731//PF09246 EGF-like domain//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Arylesterase//PHAT GO:0006355 regulation of transcription, DNA-templated GO:0003723//GO:0005509//GO:0004064//GO:0005515 RNA binding//calcium ion binding//arylesterase activity//protein binding GO:0016021 integral component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.46416 BP_3 1314.58 21.88 3188 91088439 XP_968151.1 778 1.3e-79 PREDICTED: uncharacterized protein LOC656533 [Tribolium castaneum]>gi|270011749|gb|EFA08197.1| hypothetical protein TcasGA2_TC005824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46417 BP_3 15.05 0.42 2017 91080393 XP_966637.1 1575 3.1e-172 PREDICTED: rab proteins geranylgeranyltransferase component A 1 [Tribolium castaneum]>gi|270005742|gb|EFA02190.1| hypothetical protein TcasGA2_TC007846 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXG2 755 1.5e-78 Rab proteins geranylgeranyltransferase component A 1 OS=Mus musculus GN=Chm PE=2 SV=1 PF12831 FAD dependent oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1439 RAB proteins geranylgeranyltransferase component A (RAB escort protein) Cluster-8309.46418 BP_3 226.52 2.57 4541 91083193 XP_972923.1 1404 4.6e-152 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] 347972934 XM_316946.5 74 1.50798e-27 Anopheles gambiae str. PEST AGAP008497-PA (AgaP_AGAP008497) mRNA, partial cds K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q6DG88 837 1.1e-87 Cysteine protease ATG4B OS=Danio rerio GN=atg4b PE=2 SV=2 PF03293 Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006206//GO:0006144//GO:0006810//GO:0006351//GO:0008152//GO:0019083 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transport//transcription, DNA-templated//metabolic process//viral transcription GO:0008233//GO:0003899//GO:0003677 peptidase activity//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46420 BP_3 161.55 1.86 4475 91083193 XP_972923.1 1429 5.8e-155 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] 347972934 XM_316946.5 74 1.48589e-27 Anopheles gambiae str. PEST AGAP008497-PA (AgaP_AGAP008497) mRNA, partial cds K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q6DG88 854 1.1e-89 Cysteine protease ATG4B OS=Danio rerio GN=atg4b PE=2 SV=2 PF03293 Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006508//GO:0006206//GO:0015031//GO:0019083//GO:0006351//GO:0006914//GO:0006144 proteolysis//pyrimidine nucleobase metabolic process//protein transport//viral transcription//transcription, DNA-templated//autophagy//purine nucleobase metabolic process GO:0008234//GO:0003677//GO:0003899 cysteine-type peptidase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005737 nucleolus//cytoplasm KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46421 BP_3 511.79 10.55 2629 91083193 XP_972923.1 1408 9.2e-153 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] 347972934 XM_316946.5 74 8.68576e-28 Anopheles gambiae str. PEST AGAP008497-PA (AgaP_AGAP008497) mRNA, partial cds K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q6DG88 854 6.6e-90 Cysteine protease ATG4B OS=Danio rerio GN=atg4b PE=2 SV=2 -- -- GO:0006914//GO:0015031//GO:0006508 autophagy//protein transport//proteolysis GO:0008234 cysteine-type peptidase activity GO:0005737 cytoplasm KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46422 BP_3 23.14 1.20 1218 91083193 XP_972923.1 352 1.2e-30 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] -- -- -- -- -- K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q5ZIW7 192 1.8e-13 Cysteine protease ATG4A OS=Gallus gallus GN=ATG4A PE=2 SV=1 -- -- GO:0006914//GO:0015031//GO:0006508 autophagy//protein transport//proteolysis GO:0008234 cysteine-type peptidase activity GO:0005737 cytoplasm KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46423 BP_3 3.00 0.31 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46425 BP_3 2875.60 13.71 10402 478249703 ENN70211.1 3709 0.0e+00 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 Q8R420 1191 2.2e-128 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF01225//PF00448//PF03193//PF00005//PF06414//PF13304 Mur ligase family, catalytic domain//SRP54-type protein, GTPase domain//Protein of unknown function, DUF258//ABC transporter//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006614//GO:0009058 SRP-dependent cotranslational protein targeting to membrane//biosynthetic process GO:0016887//GO:0016301//GO:0005525//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//ATP binding//GTPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.46427 BP_3 125.45 2.32 2899 91094333 XP_969230.1 955 3.4e-100 PREDICTED: acyl-protein thioesterase 1 [Tribolium castaneum] -- -- -- -- -- K06130 LYPLA2 lysophospholipase II http://www.genome.jp/dbget-bin/www_bget?ko:K06130 Q5RBR7 628 1.2e-63 Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1 PF02230//PF01738//PF00326//PF07859//PF10503//PF05577//PF01764//PF08170 Phospholipase/Carboxylesterase//Dienelactone hydrolase family//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Esterase PHB depolymerase//Serine carboxypeptidase S28//Lipase (class 3)//POPLD (NUC188) domain GO:0006629//GO:0008152//GO:0051252//GO:0008033//GO:0006396//GO:0006508 lipid metabolic process//metabolic process//regulation of RNA metabolic process//tRNA processing//RNA processing//proteolysis GO:0004526//GO:0016787//GO:0008236 ribonuclease P activity//hydrolase activity//serine-type peptidase activity GO:0030677//GO:0005576 ribonuclease P complex//extracellular region KOG2112 Lysophospholipase Cluster-8309.46428 BP_3 211.65 2.15 5035 642910386 XP_969301.3 1715 4.5e-188 PREDICTED: ribonucleases P/MRP protein subunit POP1, partial [Tribolium castaneum] -- -- -- -- -- K06130 LYPLA2 lysophospholipase II http://www.genome.jp/dbget-bin/www_bget?ko:K06130 Q5RBR7 592 3.0e-59 Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1 PF01738//PF02230//PF08170//PF00326//PF07859//PF10503//PF05577//PF01764//PF06978 Dienelactone hydrolase family//Phospholipase/Carboxylesterase//POPLD (NUC188) domain//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Esterase PHB depolymerase//Serine carboxypeptidase S28//Lipase (class 3)//Ribonucleases P/MRP protein subunit POP1 GO:0006508//GO:0001682//GO:0051252//GO:0008033//GO:0006396//GO:0008152//GO:0006629 proteolysis//tRNA 5'-leader removal//regulation of RNA metabolic process//tRNA processing//RNA processing//metabolic process//lipid metabolic process GO:0008236//GO:0016787//GO:0004526 serine-type peptidase activity//hydrolase activity//ribonuclease P activity GO:0005576//GO:0030677 extracellular region//ribonuclease P complex KOG2112 Lysophospholipase Cluster-8309.46429 BP_3 16.00 0.58 1620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4643 BP_3 24.62 0.73 1909 357628416 EHJ77759.1 705 2.2e-71 DNA-directed DNA polymerase alpha 2 [Danaus plexippus] -- -- -- -- -- K02321 POLA2 DNA polymerase alpha subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02321 Q58D13 452 2.0e-43 DNA polymerase alpha subunit B OS=Bos taurus GN=POLA2 PE=2 SV=1 PF04042//PF10471 DNA polymerase alpha/epsilon subunit B//Anaphase-promoting complex APC subunit CDC26 GO:0031145//GO:0006260//GO:0030071 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process//DNA replication//regulation of mitotic metaphase/anaphase transition GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0005680//GO:0042575 anaphase-promoting complex//DNA polymerase complex KOG1625 DNA polymerase alpha-primase complex, polymerase-associated subunit B Cluster-8309.46430 BP_3 137.23 0.86 7980 478259801 ENN79629.1 3189 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.14405e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.7e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433//PF00443 Peptidase family M1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0008270//GO:0036459//GO:0008237 zinc ion binding//ubiquitinyl hydrolase activity//metallopeptidase activity -- -- -- -- Cluster-8309.46431 BP_3 54.00 10.11 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46432 BP_3 35307.05 305.45 5863 478259801 ENN79629.1 2421 7.1e-270 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 143 8.57547e-66 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P97449 1171 2.6e-126 Aminopeptidase N OS=Mus musculus GN=Anpep PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.46433 BP_3 111.04 0.70 7913 478259801 ENN79629.1 3189 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.1344e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.6e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433//PF00443 Peptidase family M1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0008237//GO:0008270//GO:0036459 metallopeptidase activity//zinc ion binding//ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.46434 BP_3 6210.59 101.84 3231 478259801 ENN79629.1 1912 4.1e-211 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 146 1.01063e-67 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P16406 992 8.1e-106 Glutamyl aminopeptidase OS=Mus musculus GN=Enpep PE=1 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.46435 BP_3 616.41 3.84 8026 478259801 ENN79629.1 3189 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.15067e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.7e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433//PF00443 Peptidase family M1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0008270//GO:0036459//GO:0008237 zinc ion binding//ubiquitinyl hydrolase activity//metallopeptidase activity -- -- -- -- Cluster-8309.46437 BP_3 25.52 1.70 1017 478251178 ENN71654.1 875 2.3e-91 hypothetical protein YQE_11752, partial [Dendroctonus ponderosae] -- -- -- -- -- K18180 COA7, SELRC1, RESA1 cytochrome c oxidase assembly factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18180 Q9W5N0 699 2.4e-72 Cytochrome c oxidase assembly factor 7 homolog OS=Drosophila melanogaster GN=CG13865 PE=1 SV=1 PF13181 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4014 Uncharacterized conserved protein (contains TPR repeat) Cluster-8309.46438 BP_3 501.86 11.31 2431 642912496 XP_008200890.1 1793 1.9e-197 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LUQ4 218 3.4e-16 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.4644 BP_3 30.64 0.87 1988 646718133 KDR20724.1 912 2.3e-95 DNA polymerase alpha subunit B [Zootermopsis nevadensis] -- -- -- -- -- K02321 POLA2 DNA polymerase alpha subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02321 P33611 674 3.7e-69 DNA polymerase alpha subunit B OS=Mus musculus GN=Pola2 PE=1 SV=2 PF10471//PF04042 Anaphase-promoting complex APC subunit CDC26//DNA polymerase alpha/epsilon subunit B GO:0031145//GO:0006260//GO:0030071 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process//DNA replication//regulation of mitotic metaphase/anaphase transition GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0005680//GO:0042575 anaphase-promoting complex//DNA polymerase complex KOG1625 DNA polymerase alpha-primase complex, polymerase-associated subunit B Cluster-8309.46440 BP_3 798.36 4.94 8082 642926340 XP_008194885.1 3619 0.0e+00 PREDICTED: small G protein signaling modulator 1 isoform X1 [Tribolium castaneum]>gi|270009053|gb|EFA05501.1| hypothetical protein TcasGA2_TC015686 [Tribolium castaneum] 195482092 XM_002101873.1 376 0 Drosophila yakuba GE17884 (Dyak\GE17884), partial mRNA -- -- -- -- Q8BPQ7 2332 8.4e-261 Small G protein signaling modulator 1 OS=Mus musculus GN=Sgsm1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1648 Uncharacterized conserved protein, contains RUN, BRK and TBC domains Cluster-8309.46442 BP_3 12.29 0.33 2100 546680966 ERL91140.1 778 8.3e-80 hypothetical protein D910_08480 [Dendroctonus ponderosae] 642937909 XM_008202132.1 201 1.74119e-98 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 492 5.0e-48 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.46443 BP_3 17.00 1.93 717 646714789 KDR18643.1 632 2.4e-63 hypothetical protein L798_06624, partial [Zootermopsis nevadensis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 542 2.7e-54 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.46444 BP_3 17.65 2.16 685 270008800 EFA05248.1 369 7.2e-33 hypothetical protein TcasGA2_TC015399 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P19096 221 4.3e-17 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.46445 BP_3 7.00 1.20 572 478250393 ENN70888.1 258 4.5e-20 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46450 BP_3 799.00 25.77 1786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46451 BP_3 600.00 18.76 1833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46452 BP_3 1822.00 127.78 979 478250567 ENN71060.1 557 1.6e-54 hypothetical protein YQE_12244, partial [Dendroctonus ponderosae]>gi|546681270|gb|ERL91395.1| hypothetical protein D910_08727 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01817 Chorismate mutase type II GO:0046417 chorismate metabolic process -- -- -- -- -- -- Cluster-8309.46453 BP_3 1152.13 71.91 1064 91079780 XP_976161.1 264 1.7e-20 PREDICTED: uncharacterized protein LOC656005 [Tribolium castaneum]>gi|270003312|gb|EEZ99759.1| hypothetical protein TcasGA2_TC002531 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46454 BP_3 18.87 1.04 1163 91079780 XP_976161.1 264 1.8e-20 PREDICTED: uncharacterized protein LOC656005 [Tribolium castaneum]>gi|270003312|gb|EEZ99759.1| hypothetical protein TcasGA2_TC002531 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46456 BP_3 762.08 7.96 4907 91091688 XP_972411.1 1271 1.3e-136 PREDICTED: carbohydrate sulfotransferase 5 [Tribolium castaneum]>gi|270001059|gb|EEZ97506.1| hypothetical protein TcasGA2_TC011350 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QUP4 261 7.1e-21 Carbohydrate sulfotransferase 5 OS=Mus musculus GN=Chst5 PE=2 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.46457 BP_3 98.53 2.36 2306 91081127 XP_976484.1 737 5.2e-75 PREDICTED: protein maelstrom [Tribolium castaneum]>gi|270006444|gb|EFA02892.1| maelstrom [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0W2W6 466 5.7e-45 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.46458 BP_3 13.80 0.49 1663 546681066 ERL91222.1 1538 4.9e-168 hypothetical protein D910_08559 [Dendroctonus ponderosae] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 P08049 679 8.2e-70 Neprilysin OS=Oryctolagus cuniculus GN=MME PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.46459 BP_3 58.20 1.24 2555 546681066 ERL91222.1 2100 5.1e-233 hypothetical protein D910_08559 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P07861 812 4.8e-85 Neprilysin OS=Rattus norvegicus GN=Mme PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.46460 BP_3 793.10 10.67 3875 642910870 XP_008193441.1 2744 1.6e-307 PREDICTED: kinesin-like protein Klp10A isoform X1 [Tribolium castaneum] 462310547 APGK01047286.1 86 2.74256e-34 Dendroctonus ponderosae Seq01047296, whole genome shotgun sequence K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 O00139 1655 1.3e-182 Kinesin-like protein KIF2A OS=Homo sapiens GN=KIF2A PE=1 SV=3 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0246 Kinesin-like protein Cluster-8309.46461 BP_3 1.00 2.80 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46462 BP_3 970.91 10.74 4647 642922159 XP_008193039.1 2619 6.2e-293 PREDICTED: nostrin isoform X1 [Tribolium castaneum]>gi|270007234|gb|EFA03682.1| hypothetical protein TcasGA2_TC013784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6WKZ7 419 3.2e-39 Nostrin OS=Mus musculus GN=Nostrin PE=1 SV=2 PF02185//PF00018//PF14604 Hr1 repeat//SH3 domain//Variant SH3 domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4429 Uncharacterized conserved protein, contains SH3 and FCH domains Cluster-8309.46463 BP_3 4.00 0.74 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46464 BP_3 1085.25 15.79 3604 270009986 EFA06434.1 1396 3.1e-151 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.6e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF03359//PF01544//PF02653 Guanylate-kinase-associated protein (GKAP) protein//CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component GO:0055085//GO:0023052//GO:0030001//GO:0006810 transmembrane transport//signaling//metal ion transport//transport GO:0046873//GO:0005215 metal ion transmembrane transporter activity//transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.46465 BP_3 141.67 1.17 6140 642927313 XP_974796.3 1396 5.3e-151 PREDICTED: uncharacterized protein LOC663667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 4.4e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF02653//PF01544//PF03359 Branched-chain amino acid transport system / permease component//CorA-like Mg2+ transporter protein//Guanylate-kinase-associated protein (GKAP) protein GO:0055085//GO:0023052//GO:0030001//GO:0006810 transmembrane transport//signaling//metal ion transport//transport GO:0046873//GO:0005215 metal ion transmembrane transporter activity//transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.46466 BP_3 343.40 3.95 4480 642927313 XP_974796.3 1596 2.5e-174 PREDICTED: uncharacterized protein LOC663667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 3.2e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF02653//PF01544//PF03359//PF08043 Branched-chain amino acid transport system / permease component//CorA-like Mg2+ transporter protein//Guanylate-kinase-associated protein (GKAP) protein//Xin repeat GO:0023052//GO:0030036//GO:0030001//GO:0055085//GO:0006810 signaling//actin cytoskeleton organization//metal ion transport//transmembrane transport//transport GO:0046873//GO:0005215//GO:0003779 metal ion transmembrane transporter activity//transporter activity//actin binding GO:0030054//GO:0016020 cell junction//membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.46467 BP_3 289.21 1.44 9977 642927313 XP_974796.3 1396 8.6e-151 PREDICTED: uncharacterized protein LOC663667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 7.2e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF01544//PF02653//PF06221//PF03359 CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component//Putative zinc finger motif, C2HC5-type//Guanylate-kinase-associated protein (GKAP) protein GO:0006810//GO:0030001//GO:0055085//GO:0006355//GO:0023052 transport//metal ion transport//transmembrane transport//regulation of transcription, DNA-templated//signaling GO:0005215//GO:0008270//GO:0046873 transporter activity//zinc ion binding//metal ion transmembrane transporter activity GO:0005634//GO:0016020 nucleus//membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.46468 BP_3 92.90 0.94 5052 270013859 EFA10307.1 1925 2.0e-212 hypothetical protein TcasGA2_TC012523 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFP6 1230 3.2e-133 NADPH-dependent diflavin oxidoreductase 1 OS=Danio rerio GN=ndor1 PE=2 SV=1 PF01344//PF00175//PF07646//PF00667//PF00258 Kelch motif//Oxidoreductase NAD-binding domain//Kelch motif//FAD binding domain//Flavodoxin GO:0055114 oxidation-reduction process GO:0005515//GO:0016491//GO:0010181 protein binding//oxidoreductase activity//FMN binding -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.46469 BP_3 97.00 7.28 934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46472 BP_3 136.00 11.76 849 226968625 YP_002808574.1 1066 1.4e-113 NADH dehydrogenase subunit 1 [Scylla paramamosain]>gi|225697861|gb|ACO07228.1| NADH dehydrogenase subunit 1 [Scylla paramamosain] 403311088 JX457150.1 840 0 Scylla paramamosain mitochondrion, complete genome K03878 ND1 NADH-ubiquinone oxidoreductase chain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03878 P33502 829 1.7e-87 NADH-ubiquinone oxidoreductase chain 1 OS=Anopheles quadrimaculatus GN=ND1 PE=3 SV=1 PF00146 NADH dehydrogenase GO:0055114//GO:0015992//GO:0006814//GO:0006744//GO:0006120 oxidation-reduction process//proton transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0048038//GO:0008137 quinone binding//NADH dehydrogenase (ubiquinone) activity GO:0005739//GO:0016020//GO:0016021//GO:0005886 mitochondrion//membrane//integral component of membrane//plasma membrane KOG4770 NADH dehydrogenase subunit 1 Cluster-8309.46474 BP_3 72.71 1.97 2071 270010719 EFA07167.1 2030 5.5e-225 hypothetical protein TcasGA2_TC010166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH82 622 4.1e-63 SH3 domain-binding protein 5-like OS=Xenopus tropicalis GN=sh3bp5l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.46475 BP_3 42.59 0.52 4266 270010719 EFA07167.1 1038 1.2e-109 hypothetical protein TcasGA2_TC010166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U584 455 2.0e-43 SH3 domain-binding protein 5-like OS=Xenopus laevis GN=sh3bp5l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.46476 BP_3 265.90 1.85 7235 642921434 XP_008192864.1 2906 0.0e+00 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P86410 1324 5.8e-144 Ral GTPase-activating protein subunit beta OS=Rattus norvegicus GN=Ralgapb PE=1 SV=1 PF00876//PF02145//PF00237 Innexin//Rap/ran-GAP//Ribosomal protein L22p/L17e GO:0006412//GO:0042254//GO:0051056 translation//ribosome biogenesis//regulation of small GTPase mediated signal transduction GO:0005096//GO:0003735 GTPase activator activity//structural constituent of ribosome GO:0005921//GO:0005840 gap junction//ribosome KOG1711 Mitochondrial/chloroplast ribosomal protein L22 Cluster-8309.46477 BP_3 58.56 0.54 5556 642937240 XP_008198752.1 2533 6.9e-283 PREDICTED: chondroitin sulfate synthase 1 isoform X1 [Tribolium castaneum] 194768964 XM_001966545.1 125 8.23942e-56 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1667 7.4e-184 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF13506//PF01762//PF05679//PF02434 Glycosyl transferase family 21//Galactosyltransferase//Chondroitin N-acetylgalactosaminyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378//GO:0008376 transferase activity, transferring glycosyl groups//galactosyltransferase activity//acetylgalactosaminyltransferase activity GO:0016020//GO:0032580 membrane//Golgi cisterna membrane KOG3588 Chondroitin synthase 1 Cluster-8309.46479 BP_3 133.52 1.27 5364 189241624 XP_001807794.1 2521 1.6e-281 PREDICTED: chondroitin sulfate synthase 1 isoform X2 [Tribolium castaneum] 194768964 XM_001966545.1 131 3.67401e-59 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1685 5.9e-186 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF13506//PF02434//PF05679//PF01762 Glycosyl transferase family 21//Fringe-like//Chondroitin N-acetylgalactosaminyltransferase//Galactosyltransferase GO:0006486 protein glycosylation GO:0008376//GO:0008378//GO:0016757 acetylgalactosaminyltransferase activity//galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020//GO:0032580 membrane//Golgi cisterna membrane KOG3588 Chondroitin synthase 1 Cluster-8309.46483 BP_3 15.00 0.59 1522 91090210 XP_967762.1 556 3.3e-54 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18569 167 1.8e-10 Ecdysteroid UDP-glucosyltransferase OS=Autographa californica nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.46484 BP_3 39.06 0.56 3660 642928441 XP_008193786.1 225 1.9e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02148 Zn-finger in ubiquitin-hydrolases and other protein -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.46485 BP_3 174.04 2.40 3787 642928441 XP_008193786.1 225 2.0e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46486 BP_3 515.32 20.21 1521 642916091 XP_008190884.1 1064 4.1e-113 PREDICTED: alpha-L-fucosidase-like isoform X1 [Tribolium castaneum] 808126062 XM_012310694.1 95 1.05444e-39 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K01206 FUCA alpha-L-fucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01206 C3YWU0 905 4.7e-96 Alpha-L-fucosidase OS=Branchiostoma floridae GN=BRAFLDRAFT_56888 PE=3 SV=2 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0016787//GO:0004560 hydrolase activity//alpha-L-fucosidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.46487 BP_3 608.00 8.68 3669 189238478 XP_968757.2 855 1.7e-88 PREDICTED: bicaudal D-related protein homolog isoform X2 [Tribolium castaneum] 195590137 XM_002084767.1 68 2.63238e-24 Drosophila simulans GD14464 (Dsim\GD14464), mRNA K16756 CCDC64 coiled-coil domain-containing protein 64 http://www.genome.jp/dbget-bin/www_bget?ko:K16756 Q8SWR2 443 4.2e-42 Bicaudal D-related protein homolog OS=Drosophila melanogaster GN=CG17365 PE=2 SV=1 PF01544//PF01920//PF13851//PF10473 CorA-like Mg2+ transporter protein//Prefoldin subunit//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0055085//GO:0006457//GO:0030001//GO:0048870 transmembrane transport//protein folding//metal ion transport//cell motility GO:0046873//GO:0051082//GO:0042803//GO:0045502//GO:0008134 metal ion transmembrane transporter activity//unfolded protein binding//protein homodimerization activity//dynein binding//transcription factor binding GO:0016020//GO:0016272//GO:0030286//GO:0031514//GO:0005667 membrane//prefoldin complex//dynein complex//motile cilium//transcription factor complex -- -- Cluster-8309.46488 BP_3 85.95 0.38 11066 642914930 XP_008190446.1 6476 0.0e+00 PREDICTED: protein slit isoform X3 [Tribolium castaneum] 462424845 APGK01016975.1 99 4.67388e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 4903 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF00560//PF00097//PF00008//PF07645//PF14634//PF13639//PF13855 Leucine Rich Repeat//Zinc finger, C3HC4 type (RING finger)//EGF-like domain//Calcium-binding EGF domain//zinc-RING finger domain//Ring finger domain//Leucine rich repeat -- -- GO:0005515//GO:0046872//GO:0008270//GO:0005509 protein binding//metal ion binding//zinc ion binding//calcium ion binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.46489 BP_3 775.29 34.18 1385 642910558 XP_008200265.1 1075 2.0e-114 PREDICTED: ras-related protein Rab6 isoform X2 [Tribolium castaneum]>gi|270014377|gb|EFA10825.1| hypothetical protein TcasGA2_TC001600 [Tribolium castaneum] 642910557 XM_008202043.1 281 3.84154e-143 PREDICTED: Tribolium castaneum ras-related protein Rab6 (LOC661182), transcript variant X2, mRNA K07893 RAB6A Ras-related protein Rab-6A http://www.genome.jp/dbget-bin/www_bget?ko:K07893 O18334 1038 1.6e-111 Ras-related protein Rab6 OS=Drosophila melanogaster GN=Rab6 PE=1 SV=1 PF03193//PF08477//PF01926//PF04670//PF02421//PF00025//PF00071 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Gtr1/RagA G protein conserved region//Ferrous iron transport protein B//ADP-ribosylation factor family//Ras family GO:0015031//GO:0015684//GO:0007264 protein transport//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0005525//GO:0015093 GTPase activity//GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily Cluster-8309.46490 BP_3 1252.22 11.31 5627 642919894 XP_008192113.1 2193 1.9e-243 PREDICTED: mucin-17 isoform X1 [Tribolium castaneum]>gi|642919896|ref|XP_008192115.1| PREDICTED: mucin-17 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46492 BP_3 980.88 10.00 5021 91095029 XP_966439.1 854 3.1e-88 PREDICTED: ubiquitin-conjugating enzyme E2 H [Tribolium castaneum]>gi|270014763|gb|EFA11211.1| hypothetical protein TcasGA2_TC005175 [Tribolium castaneum] 462332992 APGK01039128.1 55 6.08707e-17 Dendroctonus ponderosae Seq01039138, whole genome shotgun sequence K10576 UBE2H, UBC8 ubiquitin-conjugating enzyme E2 H http://www.genome.jp/dbget-bin/www_bget?ko:K10576 P62257 751 1.1e-77 Ubiquitin-conjugating enzyme E2 H OS=Mus musculus GN=Ube2h PE=1 SV=1 PF05773 RWD domain -- -- GO:0005515//GO:0016881//GO:0005524 protein binding//acid-amino acid ligase activity//ATP binding -- -- KOG0416 Ubiquitin-protein ligase Cluster-8309.46493 BP_3 1506.16 60.94 1483 642928439 XP_008193785.1 1050 1.7e-111 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 751786134 XM_011204132.1 202 3.39468e-99 PREDICTED: Bactrocera dorsalis ras-related protein Rab-8A (LOC105225600), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P35280 874 1.8e-92 Ras-related protein Rab-8A OS=Rattus norvegicus GN=Rab8a PE=1 SV=2 PF00025//PF04670//PF00071//PF10662//PF01926//PF03193//PF08477 ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0006576//GO:0007264//GO:0015031 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.46494 BP_3 872.00 6.66 6602 642916803 XP_008199510.1 1707 5.0e-187 PREDICTED: LON peptidase N-terminal domain and RING finger protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4H7 621 1.7e-62 LON peptidase N-terminal domain and RING finger protein 3 OS=Mus musculus GN=Lonrf3 PE=2 SV=1 PF13639//PF16685//PF11789//PF02190//PF00097//PF14634 Ring finger domain//zinc RING finger of MSL2//Zinc-finger of the MIZ type in Nse subunit//ATP-dependent protease La (LON) substrate-binding domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain GO:0006510//GO:0006508 obsolete ATP-dependent proteolysis//proteolysis GO:0046872//GO:0005515//GO:0061630//GO:0004176//GO:0008270 metal ion binding//protein binding//ubiquitin protein ligase activity//ATP-dependent peptidase activity//zinc ion binding -- -- KOG4159 Predicted E3 ubiquitin ligase Cluster-8309.46495 BP_3 120.92 5.66 1322 91078476 XP_968270.1 911 2.0e-95 PREDICTED: ubiquinone biosynthesis protein COQ9, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18587 COQ9 ubiquinone biosynthesis protein COQ9 http://www.genome.jp/dbget-bin/www_bget?ko:K18587 Q8MKN0 559 5.3e-56 Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Drosophila melanogaster GN=Coq9 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2969 Uncharacterized conserved protein Cluster-8309.46496 BP_3 59.08 2.25 1558 91078476 XP_968270.1 911 2.3e-95 PREDICTED: ubiquinone biosynthesis protein COQ9, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18587 COQ9 ubiquinone biosynthesis protein COQ9 http://www.genome.jp/dbget-bin/www_bget?ko:K18587 Q8MKN0 559 6.3e-56 Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Drosophila melanogaster GN=Coq9 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2969 Uncharacterized conserved protein Cluster-8309.46497 BP_3 156.17 1.34 5904 91082203 XP_972014.1 3609 0.0e+00 PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922206|ref|XP_008193062.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922209|ref|XP_008193063.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|270007229|gb|EFA03677.1| hypothetical protein TcasGA2_TC013779 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02466 665 1.2e-67 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF05676//PF00069//PF03139//PF07714 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Protein kinase domain//Vanadium/alternative nitrogenase delta subunit//Protein tyrosine kinase GO:0006468//GO:0006120//GO:0009399//GO:0055114//GO:0015992//GO:0006814//GO:0006118//GO:0016310//GO:0019337//GO:0006807//GO:0006744 protein phosphorylation//mitochondrial electron transport, NADH to ubiquinone//nitrogen fixation//oxidation-reduction process//proton transport//sodium ion transport//obsolete electron transport//phosphorylation//tetrachloroethylene catabolic process//nitrogen compound metabolic process//ubiquinone biosynthetic process GO:0005524//GO:0008137//GO:0016163//GO:0000166//GO:0003954//GO:0004672 ATP binding//NADH dehydrogenase (ubiquinone) activity//nitrogenase activity//nucleotide binding//NADH dehydrogenase activity//protein kinase activity GO:0016610//GO:0005739 nitrogenase complex//mitochondrion KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.46498 BP_3 144.94 5.08 1668 642912146 XP_008200825.1 443 4.6e-41 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BQS4 133 1.7e-06 Protein FAM102B OS=Mus musculus GN=Fam102b PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46499 BP_3 1585.95 8.69 9085 642929329 XP_008195789.1 5307 0.0e+00 PREDICTED: unconventional myosin-X [Tribolium castaneum] 642929328 XM_008197567.1 514 0 PREDICTED: Tribolium castaneum myosin 22 (LOC662516), mRNA K12559 MYO10 myosin X http://www.genome.jp/dbget-bin/www_bget?ko:K12559 Q9U1M8 1418 9.1e-155 Myosin-I heavy chain OS=Dictyostelium discoideum GN=myoI PE=1 SV=1 PF00788//PF08416//PF00612//PF00784//PF00063 Ras association (RalGDS/AF-6) domain//Phosphotyrosine-binding domain//IQ calmodulin-binding motif//MyTH4 domain//Myosin head (motor domain) GO:0007165 signal transduction GO:0005515//GO:0005524//GO:0003774 protein binding//ATP binding//motor activity GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.46500 BP_3 219.18 8.12 1592 642918280 XP_008191442.1 840 4.1e-87 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 642918281 XM_008193221.1 184 3.70223e-89 PREDICTED: Tribolium castaneum UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (LOC655930), transcript variant X2, mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 740 6.6e-77 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13414//PF13176//PF02529//PF13374//PF00515//PF13371//PF13174//PF07721//PF13181 TPR repeat//Tetratricopeptide repeat//Cytochrome B6-F complex subunit 5//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding GO:0009512 cytochrome b6f complex KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.46502 BP_3 23.75 0.48 2652 642936089 XP_008198299.1 3439 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 2 [Tribolium castaneum]>gi|270013200|gb|EFA09648.1| hypothetical protein TcasGA2_TC011774 [Tribolium castaneum] 752890085 XM_011264720.1 230 1.67001e-114 PREDICTED: Camponotus floridanus transcription initiation factor TFIID subunit 2 (LOC105255436), mRNA K03128 TAF2 transcription initiation factor TFIID subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03128 Q6P1X5 1991 9.6e-222 Transcription initiation factor TFIID subunit 2 OS=Homo sapiens GN=TAF2 PE=1 SV=3 PF01433 Peptidase family M1 GO:0032259 methylation GO:0008270//GO:0004222//GO:0008168//GO:0003676//GO:0008237 zinc ion binding//metalloendopeptidase activity//methyltransferase activity//nucleic acid binding//metallopeptidase activity -- -- KOG1932 TATA binding protein associated factor Cluster-8309.46505 BP_3 23.84 1.76 945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46506 BP_3 14.68 0.33 2439 642937299 XP_008198776.1 572 7.5e-56 PREDICTED: DNA excision repair protein ERCC-1 [Tribolium castaneum] -- -- -- -- -- K10849 ERCC1 DNA excision repair protein ERCC-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10849 P07992 437 1.4e-41 DNA excision repair protein ERCC-1 OS=Homo sapiens GN=ERCC1 PE=1 SV=1 PF01367//PF00633//PF01296//PF10391//PF07690 5'-3' exonuclease, C-terminal SAM fold//Helix-hairpin-helix motif//Galanin//Fingers domain of DNA polymerase lambda//Major Facilitator Superfamily GO:0055085//GO:0007165 transmembrane transport//signal transduction GO:0003677//GO:0003824//GO:0034061//GO:0005179 DNA binding//catalytic activity//DNA polymerase activity//hormone activity GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG2841 Structure-specific endonuclease ERCC1-XPF, ERCC1 component Cluster-8309.46507 BP_3 463.51 10.02 2522 478260870 ENN80509.1 1625 6.1e-178 hypothetical protein YQE_03066, partial [Dendroctonus ponderosae] 195352940 XM_002042933.1 130 6.17e-59 Drosophila sechellia GM16357 (Dsec\GM16357), mRNA K09442 SPDEF SAM pointed domain-containing ETS transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09442 Q9WTP3 564 2.7e-56 SAM pointed domain-containing Ets transcription factor OS=Mus musculus GN=Spdef PE=2 SV=1 PF02198//PF00178 Sterile alpha motif (SAM)/Pointed domain//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3805 ERG and related ETS transcription factors Cluster-8309.46508 BP_3 781.25 6.78 5842 642927212 XP_008195182.1 2270 2.3e-252 PREDICTED: S phase cyclin A-associated protein in the endoplasmic reticulum [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY12 753 7.6e-78 S phase cyclin A-associated protein in the endoplasmic reticulum OS=Homo sapiens GN=SCAPER PE=1 SV=2 PF05955 Equine herpesvirus glycoprotein gp2 GO:0016032 viral process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46509 BP_3 619.38 26.79 1406 546678868 ERL89413.1 1075 2.0e-114 hypothetical protein D910_06780 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 O88531 826 6.2e-87 Palmitoyl-protein thioesterase 1 OS=Mus musculus GN=Ppt1 PE=2 SV=2 PF01674//PF02089 Lipase (class 2)//Palmitoyl protein thioesterase -- -- GO:0098599//GO:0016787 palmitoyl hydrolase activity//hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.4651 BP_3 48.00 2.63 1173 158262731 NP_001103421.1 1091 2.4e-116 histamine-gated chloride channel precursor [Tribolium castaneum]>gi|156447621|gb|ABU63603.1| histamine-gated chloride channel [Tribolium castaneum]>gi|270015115|gb|EFA11563.1| histamine-gated chloride channel subunit 2 [Tribolium castaneum] 766918223 XM_011498835.1 53 1.79811e-16 PREDICTED: Ceratosolen solmsi marchali glycine receptor subunit alpha-4 (LOC105361587), mRNA K05271 GLRA4 glycine receptor alpha-4 http://www.genome.jp/dbget-bin/www_bget?ko:K05271 P24524 336 3.4e-30 Glycine receptor subunit alpha-3 OS=Rattus norvegicus GN=Glra3 PE=2 SV=1 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016021//GO:0005886//GO:0030054//GO:0016020//GO:0045211 integral component of membrane//plasma membrane//cell junction//membrane//postsynaptic membrane KOG3644 Ligand-gated ion channel Cluster-8309.46510 BP_3 4063.24 58.18 3658 642932512 XP_008197144.1 2807 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum]>gi|642932514|ref|XP_008197145.1| PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum] 642932517 XM_008198925.1 654 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 P32023 2359 2.8e-264 cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 OS=Drosophila melanogaster GN=for PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.46511 BP_3 43.24 2.26 1214 546680684 ERL90910.1 475 6.6e-45 hypothetical protein D910_08254 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZL12 135 7.2e-07 Protein phosphatase 1 regulatory subunit 21 OS=Gallus gallus GN=PPP1R21 PE=2 SV=1 PF04799//PF07926//PF10473//PF00170 fzo-like conserved region//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//bZIP transcription factor GO:0006606//GO:0008053//GO:0006355 protein import into nucleus//mitochondrial fusion//regulation of transcription, DNA-templated GO:0008134//GO:0003924//GO:0045502//GO:0043565//GO:0042803//GO:0003700 transcription factor binding//GTPase activity//dynein binding//sequence-specific DNA binding//protein homodimerization activity//transcription factor activity, sequence-specific DNA binding GO:0030286//GO:0016021//GO:0005667//GO:0005741 dynein complex//integral component of membrane//transcription factor complex//mitochondrial outer membrane -- -- Cluster-8309.46513 BP_3 1086.10 22.33 2636 642935023 XP_008199910.1 1210 8.4e-130 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 770 3.6e-80 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF11547//PF08925 E3 ubiquitin ligase EDD//Domain of Unknown Function (DUF1907) -- -- GO:0043130 ubiquitin binding GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.46516 BP_3 13.70 0.48 1658 642915592 XP_008190679.1 1711 4.3e-188 PREDICTED: tyrosine-protein phosphatase Lar isoform X5 [Tribolium castaneum] -- -- -- -- -- K06777 PTPRD receptor-type tyrosine-protein phosphatase delta http://www.genome.jp/dbget-bin/www_bget?ko:K06777 P16621 1344 6.3e-147 Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46517 BP_3 78.18 1.79 2402 478253832 ENN74124.1 1426 6.9e-155 hypothetical protein YQE_09097, partial [Dendroctonus ponderosae]>gi|546684638|gb|ERL94255.1| hypothetical protein D910_11536 [Dendroctonus ponderosae] 749785289 XM_011148089.1 84 2.1881e-33 PREDICTED: Harpegnathos saltator probable E3 ubiquitin-protein ligase makorin-1 (LOC105187344), mRNA K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q5NU14 740 1.0e-76 Probable E3 ubiquitin-protein ligase makorin-1 OS=Takifugu rubripes GN=mkrn1 PE=2 SV=1 PF00097//PF12678//PF14634//PF13639//PF16685//PF16954//PF00642//PF12861 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain//Ring finger domain//zinc RING finger of MSL2//Haem-transporter, endosomal/lysosomal, haem-responsive gene//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567//GO:0015886 protein ubiquitination//heme transport GO:0015232//GO:0005515//GO:0061630//GO:0004842//GO:0008270//GO:0046872 heme transporter activity//protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//zinc ion binding//metal ion binding GO:0005680 anaphase-promoting complex KOG1039 Predicted E3 ubiquitin ligase Cluster-8309.46521 BP_3 18.66 0.84 1359 170321839 BAG14264.1 334 1.6e-28 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P79953 162 6.0e-10 Ovochymase-2 OS=Xenopus laevis GN=ovch2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.46528 BP_3 18.91 0.46 2258 478255819 ENN76027.1 844 2.0e-87 hypothetical protein YQE_07403, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.46531 BP_3 46.66 4.66 774 642937272 XP_008198766.1 1042 7.5e-111 PREDICTED: PH and SEC7 domain-containing protein 1 isoform X1 [Tribolium castaneum] 642937277 XM_008200547.1 180 2.94531e-87 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X4, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 468 1.1e-45 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF16867 Dimethlysulfonioproprionate lyase -- -- GO:0047869 dimethylpropiothetin dethiomethylase activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.46532 BP_3 78.84 1.54 2766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46533 BP_3 164.47 2.60 3341 642934081 XP_008196456.1 1036 1.6e-109 PREDICTED: phosphatase and actin regulator 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.5e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00957//PF00344 Synaptobrevin//SecY translocase GO:0016192//GO:0015031 vesicle-mediated transport//protein transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.46535 BP_3 193.17 1.27 7625 478249959 ENN70466.1 989 1.0e-103 hypothetical protein YQE_12969, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46539 BP_3 458.50 9.38 2647 642924566 XP_008194346.1 1572 8.9e-172 PREDICTED: endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform X1 [Tribolium castaneum]>gi|270007946|gb|EFA04394.1| hypothetical protein TcasGA2_TC014693 [Tribolium castaneum] 827553572 XM_004929230.2 77 1.87984e-29 PREDICTED: Bombyx mori endoplasmic reticulum-Golgi intermediate compartment protein 3 (LOC101741074), mRNA -- -- -- -- Q803I2 1024 1.3e-109 Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Danio rerio GN=ergic3 PE=2 SV=1 PF04976 DMSO reductase anchor subunit (DmsC) GO:0019645 anaerobic electron transport chain -- -- GO:0016021 integral component of membrane KOG2667 COPII vesicle protein Cluster-8309.46544 BP_3 7.00 0.55 900 157138609 XP_001664277.1 735 3.5e-75 AAEL003891-PA [Aedes aegypti]>gi|108880565|gb|EAT44790.1| AAEL003891-PA [Aedes aegypti] -- -- -- -- -- K06515 SLC44A1, CDW92 solute carrier family 44 (choline transporter-like protein), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06515 Q54I48 455 4.2e-44 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.46551 BP_3 12.14 0.51 1433 642923174 XP_008193640.1 424 6.4e-39 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29RT6 274 6.5e-23 Kinesin-like protein KIF20A OS=Bos taurus GN=KIF20A PE=2 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.46552 BP_3 11.00 1.60 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46553 BP_3 39.00 1.41 1627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.46556 BP_3 11.41 0.54 1310 630585733 AHZ00135.1 568 1.2e-55 pyruvate dehydrogenase, partial [Spinotectarchus acornutus] 769840408 XM_011633076.1 90 5.44499e-37 PREDICTED: Pogonomyrmex barbatus probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (LOC105423352), transcript variant X2, mRNA K00161 PDHA, pdhA pyruvate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00161 P52899 485 2.0e-47 Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Caenorhabditis elegans GN=T05H10.6 PE=3 SV=1 PF00676 Dehydrogenase E1 component GO:0008152 metabolic process GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.46557 BP_3 92.25 0.95 4968 642917577 XP_008191264.1 750 3.5e-76 PREDICTED: zinc transporter ZIP11 isoform X3 [Tribolium castaneum] -- -- -- -- -- K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 P43005 456 1.8e-43 Excitatory amino acid transporter 3 OS=Homo sapiens GN=SLC1A1 PE=1 SV=2 PF01903//PF00375//PF02535 CbiX//Sodium:dicarboxylate symporter family//ZIP Zinc transporter GO:0030001//GO:0055085//GO:0006783//GO:0009236//GO:0006820//GO:0006812//GO:0006835 metal ion transport//transmembrane transport//heme biosynthetic process//cobalamin biosynthetic process//anion transport//cation transport//dicarboxylic acid transport GO:0017153//GO:0016852//GO:0046873 sodium:dicarboxylate symporter activity//sirohydrochlorin cobaltochelatase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.46561 BP_3 32.04 7.04 511 642920332 XP_975626.2 405 3.6e-37 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17078//PF04048 SWI5-dependent HO expression protein 3//Sec8 exocyst complex component specific domain GO:0051028//GO:0006904//GO:0015031//GO:0048309 mRNA transport//vesicle docking involved in exocytosis//protein transport//endoplasmic reticulum inheritance -- -- GO:0000145 exocyst KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.46565 BP_3 525.81 6.28 4326 91078172 XP_967060.1 1454 7.0e-158 PREDICTED: sorting nexin-27 [Tribolium castaneum]>gi|270001364|gb|EEZ97811.1| hypothetical protein TcasGA2_TC000177 [Tribolium castaneum] 573908103 XM_006641708.1 114 8.34221e-50 PREDICTED: Lepisosteus oculatus sorting nexin-27-like (LOC102684965), mRNA K17936 SNX27 sorting nexin-27 http://www.genome.jp/dbget-bin/www_bget?ko:K17936 A5PKA5 1014 3.0e-108 Sorting nexin-27 OS=Bos taurus GN=SNX27 PE=2 SV=1 PF00788//PF01544//PF00787//PF00595//PF13180 Ras association (RalGDS/AF-6) domain//CorA-like Mg2+ transporter protein//PX domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0055085//GO:0030001//GO:0007165 transmembrane transport//metal ion transport//signal transduction GO:0005515//GO:0035091//GO:0046873 protein binding//phosphatidylinositol binding//metal ion transmembrane transporter activity GO:0016020 membrane KOG3784 Sorting nexin protein SNX27 Cluster-8309.46566 BP_3 65.45 0.76 4416 91078172 XP_967060.1 1454 7.2e-158 PREDICTED: sorting nexin-27 [Tribolium castaneum]>gi|270001364|gb|EEZ97811.1| hypothetical protein TcasGA2_TC000177 [Tribolium castaneum] 573908103 XM_006641708.1 114 8.51722e-50 PREDICTED: Lepisosteus oculatus sorting nexin-27-like (LOC102684965), mRNA K17936 SNX27 sorting nexin-27 http://www.genome.jp/dbget-bin/www_bget?ko:K17936 A5PKA5 1014 3.1e-108 Sorting nexin-27 OS=Bos taurus GN=SNX27 PE=2 SV=1 PF00788//PF01544//PF00787//PF00595//PF13180 Ras association (RalGDS/AF-6) domain//CorA-like Mg2+ transporter protein//PX domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0055085//GO:0007165//GO:0030001 transmembrane transport//signal transduction//metal ion transport GO:0005515//GO:0035091//GO:0046873 protein binding//phosphatidylinositol binding//metal ion transmembrane transporter activity GO:0016020 membrane KOG3784 Sorting nexin protein SNX27 Cluster-8309.46567 BP_3 122.78 1.39 4557 642931654 XP_008196673.1 2387 4.8e-266 PREDICTED: rap1 GTPase-activating protein 1 isoform X1 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.49208e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 4.0e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF02145//PF07836//PF02188//PF13851 Rap/ran-GAP//DmpG-like communication domain//GoLoco motif//Growth-arrest specific micro-tubule binding GO:0019439//GO:0051056//GO:0048870 aromatic compound catabolic process//regulation of small GTPase mediated signal transduction//cell motility GO:0030695//GO:0005096//GO:0016833 GTPase regulator activity//GTPase activator activity//oxo-acid-lyase activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46569 BP_3 653.12 14.81 2417 642917000 XP_008199589.1 461 5.5e-43 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 206 8.4e-15 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.46570 BP_3 112.02 4.52 1487 642932834 XP_008197005.1 1294 8.6e-140 PREDICTED: uncharacterized protein LOC663161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46574 BP_3 92.92 0.77 6110 642937382 XP_008198814.1 4353 0.0e+00 PREDICTED: GTPase-activating Rap/Ran-GAP domain-like protein 3 [Tribolium castaneum] 642937381 XM_008200592.1 830 0 PREDICTED: Tribolium castaneum GTPase-activating Rap/Ran-GAP domain-like protein 3 (LOC656074), mRNA -- -- -- -- Q5VVW2 2037 1.0e-226 GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Homo sapiens GN=GARNL3 PE=2 SV=2 PF03124//PF02145 EXS family//Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity GO:0016021 integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46575 BP_3 947.08 7.85 6109 642937382 XP_008198814.1 4353 0.0e+00 PREDICTED: GTPase-activating Rap/Ran-GAP domain-like protein 3 [Tribolium castaneum] 642937381 XM_008200592.1 830 0 PREDICTED: Tribolium castaneum GTPase-activating Rap/Ran-GAP domain-like protein 3 (LOC656074), mRNA -- -- -- -- Q5VVW2 2037 1.0e-226 GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Homo sapiens GN=GARNL3 PE=2 SV=2 PF03124//PF02145 EXS family//Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity GO:0016021 integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46576 BP_3 3418.14 48.54 3686 642915807 XP_008200086.1 3638 0.0e+00 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 572308789 XM_006620141.1 286 1.72522e-145 PREDICTED: Apis dorsata WD repeat-containing protein 47-like (LOC102670854), mRNA -- -- -- -- Q8CGF6 1106 5.6e-119 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.46577 BP_3 76.59 1.15 3501 329350997 AEB91339.1 2095 2.7e-232 salicyl alcohol oxidase paralog 1 [Chrysomela lapponica] -- -- -- -- -- -- -- -- -- P18172 1049 2.2e-112 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF02254//PF01266//PF00732//PF05834//PF07992 GMC oxidoreductase//TrkA-N domain//FAD dependent oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0006813//GO:0016117 oxidation-reduction process//potassium ion transport//carotenoid biosynthetic process GO:0016491//GO:0016614//GO:0016705//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.46578 BP_3 69.27 0.33 10543 189236510 XP_975373.2 2538 3.5e-283 PREDICTED: insulin-like receptor [Tribolium castaneum] 471364329 XM_004372657.1 83 3.49084e-32 PREDICTED: Trichechus manatus latirostris insulin-like growth factor 1 receptor (LOC101355333), mRNA K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q60751 1871 3.1e-207 Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 PF08727//PF16656//PF00757//PF00909//PF00041//PF00069//PF07714 Poliovirus 3A protein like//Purple acid Phosphatase, N-terminal domain//Furin-like cysteine rich region//Ammonium Transporter Family//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0019497//GO:0006144//GO:0015696//GO:0007169//GO:0006771//GO:0006508 protein phosphorylation//hexachlorocyclohexane metabolic process//purine nucleobase metabolic process//ammonium transport//transmembrane receptor protein tyrosine kinase signaling pathway//riboflavin metabolic process//proteolysis GO:0008519//GO:0005524//GO:0003993//GO:0005515//GO:0004197//GO:0046872//GO:0004672//GO:0004714//GO:0017111//GO:0003968 ammonium transmembrane transporter activity//ATP binding//acid phosphatase activity//protein binding//cysteine-type endopeptidase activity//metal ion binding//protein kinase activity//transmembrane receptor protein tyrosine kinase activity//nucleoside-triphosphatase activity//RNA-directed RNA polymerase activity GO:0031379//GO:0016020 RNA-directed RNA polymerase complex//membrane KOG3796 Ammonium transporter RHBG Cluster-8309.46580 BP_3 63.79 0.58 5552 91082499 XP_972877.1 1497 9.3e-163 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU29 852 2.4e-89 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF04097//PF06701//PF00637//PF16276//PF02066//PF00569//PF04121 Nup93/Nic96//Mib_herc2//Region in Clathrin and VPS//Nucleophosmin C-terminal domain//Metallothionein family 11//Zinc finger, ZZ type//Nuclear pore protein 84 / 107 GO:0016567//GO:0006810//GO:0016192//GO:0006886 protein ubiquitination//transport//vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0003676//GO:0008270//GO:0004842//GO:0005507 metal ion binding//nucleic acid binding//zinc ion binding//ubiquitin-protein transferase activity//copper ion binding GO:0005643 nuclear pore KOG2855 Ribokinase Cluster-8309.46581 BP_3 266.55 2.43 5587 642932522 XP_008197149.1 945 9.6e-99 PREDICTED: ribokinase [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 653 2.8e-66 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF04097//PF02066//PF00569//PF04121//PF06701//PF16276 Nup93/Nic96//Metallothionein family 11//Zinc finger, ZZ type//Nuclear pore protein 84 / 107//Mib_herc2//Nucleophosmin C-terminal domain GO:0016567//GO:0006810 protein ubiquitination//transport GO:0005507//GO:0004842//GO:0003676//GO:0008270//GO:0046872 copper ion binding//ubiquitin-protein transferase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005643 nuclear pore -- -- Cluster-8309.46582 BP_3 23.25 0.50 2544 91090496 XP_969212.1 763 5.5e-78 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] -- -- -- -- -- K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 421 1.0e-39 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0006520//GO:0006508//GO:0000051//GO:0008152 cellular amino acid metabolic process//proteolysis//obsolete urea cycle intermediate metabolic process//metabolic process GO:0008237//GO:0004046//GO:0016787 metallopeptidase activity//aminoacylase activity//hydrolase activity GO:0005737 cytoplasm KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.46583 BP_3 679.93 4.17 8156 189241962 XP_968788.2 835 8.0e-86 PREDICTED: remodeling and spacing factor 1-like [Tribolium castaneum] -- -- -- -- -- K11657 RSF1 remodeling and spacing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11657 Q96T23 382 1.1e-34 Remodeling and spacing factor 1 OS=Homo sapiens GN=RSF1 PE=1 SV=2 PF00628//PF10404//PF01428 PHD-finger//Rad4 beta-hairpin domain 2//AN1-like Zinc finger -- -- GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.46584 BP_3 1335.82 7.99 8351 642926988 XP_008195092.1 1922 7.3e-212 PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum]>gi|642926990|ref|XP_008195093.1| PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum] 642926985 XM_008196869.1 122 5.77194e-54 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX27 (LOC103313489), mRNA K01320 F7 coagulation factor VII http://www.genome.jp/dbget-bin/www_bget?ko:K01320 P21902 337 1.9e-29 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF02468 Trypsin//Photosystem II reaction centre N protein (psbN) GO:0006508//GO:0015979 proteolysis//photosynthesis GO:0004252 serine-type endopeptidase activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.46585 BP_3 1452.22 25.97 2987 270008674 EFA05122.1 2411 5.2e-269 hypothetical protein TcasGA2_TC015236 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 1015 1.6e-108 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF01691//PF00523//PF00916//PF03083//PF01566 Adenovirus E1B 19K protein / small t-antigen//Fusion glycoprotein F0//Sulfate permease family//Sugar efflux transporter for intercellular exchange//Natural resistance-associated macrophage protein GO:0006810//GO:0043066//GO:0008272//GO:0006948 transport//negative regulation of apoptotic process//sulfate transport//induction by virus of host cell-cell fusion GO:0005215//GO:0015116//GO:0005521 transporter activity//sulfate transmembrane transporter activity//lamin binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.46587 BP_3 62.25 0.45 6977 642937185 XP_008198729.1 2693 2.4e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 3.75103e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.3e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF13606//PF00023//PF00995//PF05192//PF11744 Ankyrin repeat//Ankyrin repeat//Sec1 family//MutS domain III//Aluminium activated malate transporter GO:0006298//GO:0006904//GO:0015743//GO:0016192 mismatch repair//vesicle docking involved in exocytosis//malate transport//vesicle-mediated transport GO:0005524//GO:0030983//GO:0005515 ATP binding//mismatched DNA binding//protein binding -- -- KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.46588 BP_3 397.05 6.25 3356 270001264 EEZ97711.1 2291 4.8e-255 Ras opposite [Tribolium castaneum] 7321217 Y12732.2 114 6.45598e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 1930 1.4e-214 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF05192//PF11744//PF00995 MutS domain III//Aluminium activated malate transporter//Sec1 family GO:0006298//GO:0015743//GO:0006904//GO:0016192 mismatch repair//malate transport//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.46589 BP_3 740.69 9.28 4137 642915700 XP_008190765.1 3242 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X3 [Tribolium castaneum] 642915699 XM_008192543.1 679 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 6.3e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.46590 BP_3 1085.22 10.89 5095 270010529 EFA06977.1 4750 0.0e+00 hypothetical protein TcasGA2_TC009937 [Tribolium castaneum] 642929423 XM_008197612.1 78 1.01199e-29 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X2, mRNA -- -- -- -- Q9UIF8 496 4.2e-48 Bromodomain adjacent to zinc finger domain protein 2B OS=Homo sapiens GN=BAZ2B PE=1 SV=3 PF01221//PF16866//PF00628//PF00130//PF00439//PF08926 Dynein light chain type 1//PHD-finger//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain//Domain of unknown function (DUF1908) GO:0035556//GO:0007017//GO:0016310//GO:0009069//GO:0006468 intracellular signal transduction//microtubule-based process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0000287//GO:0004674//GO:0005515//GO:0005524 magnesium ion binding//protein serine/threonine kinase activity//protein binding//ATP binding GO:0005875 microtubule associated complex KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.46593 BP_3 442.29 2.70 8195 642918629 XP_008200387.1 2425 3.4e-270 PREDICTED: serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2 [Tribolium castaneum] 642918632 XM_008202178.1 276 1.39626e-139 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 6 regulatory subunit 3 (LOC655675), transcript variant X5, mRNA K15501 PPP6R3, SAPS3 serine/threonine-protein phosphatase 6 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15501 Q5F471 1177 7.2e-127 Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Gallus gallus GN=PPP6R3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2073 SAP family cell cycle dependent phosphatase-associated protein Cluster-8309.46594 BP_3 40.21 0.56 3781 642928439 XP_008193785.1 891 1.2e-92 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 751786134 XM_011204132.1 190 4.11252e-92 PREDICTED: Bactrocera dorsalis ras-related protein Rab-8A (LOC105225600), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P35280 825 2.2e-86 Ras-related protein Rab-8A OS=Rattus norvegicus GN=Rab8a PE=1 SV=2 PF00025//PF04670//PF00071//PF10662//PF08477//PF03193//PF01926 ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0006576//GO:0007264//GO:0015031 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.46595 BP_3 22.14 0.31 3769 642928439 XP_008193785.1 891 1.2e-92 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 751786134 XM_011204132.1 190 4.09935e-92 PREDICTED: Bactrocera dorsalis ras-related protein Rab-8A (LOC105225600), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P55258 825 2.2e-86 Ras-related protein Rab-8A OS=Mus musculus GN=Rab8a PE=1 SV=2 PF04670//PF00025//PF10662//PF00071//PF01926//PF08477//PF03193 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation//Ras family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0007264//GO:0015031//GO:0006576 small GTPase mediated signal transduction//protein transport//cellular biogenic amine metabolic process GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.46596 BP_3 106.02 4.29 1482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01446 Replication protein GO:0006260 DNA replication GO:0003677 DNA binding GO:0005727 extrachromosomal circular DNA -- -- Cluster-8309.46598 BP_3 64.82 1.88 1956 270013391 EFA09839.1 2971 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 275 1.18326e-139 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 286 3.6e-24 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.46602 BP_3 1470.06 26.66 2949 642922112 XP_008193020.1 768 1.7e-78 PREDICTED: calcium channel flower isoform X2 [Tribolium castaneum]>gi|270007428|gb|EFA03876.1| hypothetical protein TcasGA2_TC014000 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MXW6 393 2.1e-36 Calcium channel flower OS=Drosophila willistoni GN=flower PE=3 SV=2 PF10233//PF03613 Uncharacterized conserved protein CG6151-P//PTS system mannose/fructose/sorbose family IID component GO:0006816//GO:0009401//GO:0048488//GO:0070588 calcium ion transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//synaptic vesicle endocytosis//calcium ion transmembrane transport GO:0005262 calcium channel activity GO:0016021//GO:0030285 integral component of membrane//integral component of synaptic vesicle membrane KOG4085 Uncharacterized conserved protein Cluster-8309.46604 BP_3 8.61 0.46 1191 270003477 EEZ99924.1 1199 7.2e-129 hypothetical protein TcasGA2_TC002717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 947 4.9e-101 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF13417//PF07651 Glutathione S-transferase, N-terminal domain//ANTH domain -- -- GO:0005543//GO:0005515 phospholipid binding//protein binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.46605 BP_3 125.06 0.55 11314 642925080 XP_008194161.1 4665 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A1 [Tribolium castaneum] 573902448 XM_006638886.1 156 9.84486e-73 PREDICTED: Lepisosteus oculatus lysine-specific demethylase 6A-like (LOC102692642), transcript variant X4, mRNA K14950 ATP13A1 cation-transporting ATPase 13A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14950 Q9HD20 3312 0.0e+00 Manganese-transporting ATPase 13A1 OS=Homo sapiens GN=ATP13A1 PE=1 SV=2 PF13414//PF02388//PF03938//PF00782//PF00515//PF00122//PF13949//PF00102//PF08797//PF13181 TPR repeat//FemAB family//Outer membrane protein (OmpH-like)//Dual specificity phosphatase, catalytic domain//Tetratricopeptide repeat//E1-E2 ATPase//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//HIRAN domain//Tetratricopeptide repeat GO:0006570//GO:0006470//GO:0009252 tyrosine metabolic process//protein dephosphorylation//peptidoglycan biosynthetic process GO:0004725//GO:0005515//GO:0008138//GO:0016755//GO:0046872//GO:0016818//GO:0003676//GO:0051082//GO:0008270//GO:0000166 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//transferase activity, transferring amino-acyl groups//metal ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//unfolded protein binding//zinc ion binding//nucleotide binding -- -- KOG0209 P-type ATPase Cluster-8309.46609 BP_3 218.28 2.25 4962 189237952 XP_001813626.1 1883 1.5e-207 PREDICTED: methyltransferase-like protein 13 [Tribolium castaneum]>gi|270008036|gb|EFA04484.1| hypothetical protein TcasGA2_TC014789 [Tribolium castaneum] 332372815 BT126586.1 196 2.49902e-95 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q3SX43 1348 6.5e-147 Ras-related GTP-binding protein A OS=Bos taurus GN=RRAGA PE=2 SV=1 PF00005//PF03193//PF00503//PF01209//PF00484//PF04670//PF00071//PF10662//PF08241//PF08477//PF01926//PF07516//PF00025 ABC transporter//Protein of unknown function, DUF258//G-protein alpha subunit//ubiE/COQ5 methyltransferase family//Carbonic anhydrase//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//Methyltransferase domain//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//SecA Wing and Scaffold domain//ADP-ribosylation factor family GO:0007165//GO:0017038//GO:0006730//GO:0007186//GO:0008152//GO:0006576//GO:0006807//GO:0007264//GO:0032259 signal transduction//protein import//one-carbon metabolic process//G-protein coupled receptor signaling pathway//metabolic process//cellular biogenic amine metabolic process//nitrogen compound metabolic process//small GTPase mediated signal transduction//methylation GO:0005524//GO:0031683//GO:0003924//GO:0008168//GO:0008270//GO:0019001//GO:0016887//GO:0004089//GO:0005525//GO:0004871 ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//methyltransferase activity//zinc ion binding//guanyl nucleotide binding//ATPase activity//carbonate dehydratase activity//GTP binding//signal transducer activity GO:0016020 membrane KOG3886 GTP-binding protein Cluster-8309.46610 BP_3 199.79 3.94 2733 642918280 XP_008191442.1 388 1.8e-34 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] -- -- -- -- -- K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 371 7.0e-34 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.46611 BP_3 3.42 0.53 604 642916126 XP_008190896.1 198 4.3e-13 PREDICTED: uncharacterized protein LOC661413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.46612 BP_3 54.10 0.57 4882 642918959 XP_008191673.1 1172 4.0e-125 PREDICTED: NEDD8 ultimate buster 1-like [Tribolium castaneum]>gi|270005608|gb|EFA02056.1| hypothetical protein TcasGA2_TC007685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54729 466 1.2e-44 NEDD8 ultimate buster 1 OS=Mus musculus GN=Nub1 PE=1 SV=2 PF13414//PF03711//PF07721//PF13374//PF00240 TPR repeat//Orn/Lys/Arg decarboxylase, C-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Ubiquitin family -- -- GO:0005515//GO:0003824//GO:0042802 protein binding//catalytic activity//identical protein binding -- -- KOG2561 Adaptor protein NUB1, contains UBA domain Cluster-8309.46613 BP_3 40.82 0.34 6086 642912926 XP_008201309.1 1747 1.0e-191 PREDICTED: LOW QUALITY PROTEIN: RNA polymerase II-associated factor 1 homolog [Tribolium castaneum] 808145633 XM_012318648.1 294 1.02125e-149 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K15174 PAF1 RNA polymerase II-associated factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15174 B3A0N5 1282 3.6e-139 Apyrase OS=Tabanus yao PE=1 SV=1 PF02872//PF01757//PF00149//PF03985 5'-nucleotidase, C-terminal domain//Acyltransferase family//Calcineurin-like phosphoesterase//Paf1 GO:0016570//GO:0009166//GO:0006368 histone modification//nucleotide catabolic process//transcription elongation from RNA polymerase II promoter GO:0016787//GO:0016747 hydrolase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016593 Cdc73/Paf1 complex KOG2478 Putative RNA polymerase II regulator Cluster-8309.46614 BP_3 117.00 6.24 1196 189238518 XP_001811514.1 354 6.9e-31 PREDICTED: dnaJ homolog subfamily C member 30 [Tribolium castaneum]>gi|270009074|gb|EFA05522.1| hypothetical protein TcasGA2_TC015709 [Tribolium castaneum] -- -- -- -- -- K09515 DNAJB9 DnaJ homolog subfamily B member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K09515 P97554 197 4.6e-14 DnaJ homolog subfamily B member 9 OS=Rattus norvegicus GN=Dnajb9 PE=2 SV=2 PF09004 Domain of unknown function (DUF1891) GO:0055114 oxidation-reduction process GO:0016706//GO:0008168 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//methyltransferase activity -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.46615 BP_3 201.92 3.07 3461 642919877 XP_008192107.1 3469 0.0e+00 PREDICTED: N-acetyltransferase 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14521 NAT10, KRE33 N-acetyltransferase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14521 Q8K224 2966 0.0e+00 N-acetyltransferase 10 OS=Mus musculus GN=Nat10 PE=2 SV=1 PF13718//PF13508//PF00583 GNAT acetyltransferase 2//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG2036 Predicted P-loop ATPase fused to an acetyltransferase Cluster-8309.46616 BP_3 17.16 1.21 974 478251160 ENN71636.1 637 8.6e-64 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46617 BP_3 184.57 1.85 5088 546685821 ERL95264.1 1051 4.5e-111 hypothetical protein D910_12530 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843//PF04931//PF02724//PF01080 Herpesvirus tegument protein, N-terminal conserved region//DNA polymerase phi//CDC45-like protein//Presenilin GO:0006260//GO:0006508//GO:0006270//GO:0006351 DNA replication//proteolysis//DNA replication initiation//transcription, DNA-templated GO:0008233//GO:0003887//GO:0003677//GO:0004190 peptidase activity//DNA-directed DNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0042575//GO:0016021 DNA polymerase complex//integral component of membrane -- -- Cluster-8309.46618 BP_3 54.23 0.82 3488 478251160 ENN71636.1 816 5.4e-84 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46619 BP_3 318.03 7.21 2419 332374250 AEE62266.1 1841 5.3e-203 unknown [Dendroctonus ponderosae]>gi|478251803|gb|ENN72249.1| hypothetical protein YQE_11112, partial [Dendroctonus ponderosae]>gi|546684740|gb|ERL94350.1| hypothetical protein D910_11631 [Dendroctonus ponderosae] -- -- -- -- -- K01102 PDP pyruvate dehydrogenase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01102 Q3UV70 975 5.7e-104 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Mus musculus GN=Pdp1 PE=2 SV=1 PF00481//PF03110 Protein phosphatase 2C//SBP domain -- -- GO:0003824//GO:0003677 catalytic activity//DNA binding GO:0005634 nucleus KOG0700 Protein phosphatase 2C/pyruvate dehydrogenase (lipoamide) phosphatase Cluster-8309.4662 BP_3 2.00 1.17 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46620 BP_3 35.87 0.64 3000 642928133 XP_008200170.1 285 1.7e-22 PREDICTED: G protein pathway suppressor 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15307 GPS2 G protein pathway suppressor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15307 Q13227 149 4.2e-08 G protein pathway suppressor 2 OS=Homo sapiens GN=GPS2 PE=1 SV=3 PF15048//PF09573//PF05929//PF03839//PF04977//PF04111 Organic solute transporter subunit beta protein//TaqI restriction endonuclease//Phage capsid scaffolding protein (GPO) serine peptidase//Translocation protein Sec62//Septum formation initiator//Autophagy protein Apg6 GO:0015721//GO:0006810//GO:0006914//GO:0015031//GO:0007049//GO:0009307//GO:0006308//GO:0019069 bile acid and bile salt transport//transport//autophagy//protein transport//cell cycle//DNA restriction-modification system//DNA catabolic process//viral capsid assembly GO:0008565//GO:0046982//GO:0005215//GO:0003677//GO:0009036 protein transporter activity//protein heterodimerization activity//transporter activity//DNA binding//Type II site-specific deoxyribonuclease activity GO:0016021//GO:0005886//GO:0009359 integral component of membrane//plasma membrane//Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.46621 BP_3 20.84 0.47 2430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46624 BP_3 608.63 4.59 6677 642914058 XP_008201527.1 6845 0.0e+00 PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 2022 6.1e-225 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00435 Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.46625 BP_3 2999.04 12.47 11880 642914062 XP_008201529.1 13841 0.0e+00 PREDICTED: spectrin beta chain, non-erythrocytic 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3138 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00435//PF14604//PF00018//PF11616//PF00307 Spectrin repeat//Variant SH3 domain//SH3 domain//WD repeat binding protein EZH2//Calponin homology (CH) domain GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.46626 BP_3 379.47 2.89 6612 270002146 EEZ98593.1 6803 0.0e+00 hypothetical protein TcasGA2_TC001109 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 2022 6.1e-225 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00435 Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.46627 BP_3 933.54 3.24 14177 642914062 XP_008201529.1 14400 0.0e+00 PREDICTED: spectrin beta chain, non-erythrocytic 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3138 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00307//PF11616//PF00018//PF14604//PF00435 Calponin homology (CH) domain//WD repeat binding protein EZH2//SH3 domain//Variant SH3 domain//Spectrin repeat GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.46628 BP_3 237.84 1.85 6505 642933881 XP_008197550.1 1596 3.6e-174 PREDICTED: protein phosphatase PP2A 55 kDa regulatory subunit isoform X3 [Tribolium castaneum] 817186518 XM_012432341.1 231 1.14687e-114 PREDICTED: Orussus abietinus protein phosphatase PP2A 55 kDa regulatory subunit (LOC105703734), transcript variant X6, mRNA K04354 PPP2R2 serine/threonine-protein phosphatase 2A regulatory subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K04354 P36872 1423 1.7e-155 Protein phosphatase PP2A 55 kDa regulatory subunit OS=Drosophila melanogaster GN=tws PE=2 SV=1 PF00400//PF11093//PF13463//PF13465 WD domain, G-beta repeat//Mitochondrial export protein Som1//Winged helix DNA-binding domain//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0046872//GO:0005515 transcription factor activity, sequence-specific DNA binding//metal ion binding//protein binding GO:0042720//GO:0005667 mitochondrial inner membrane peptidase complex//transcription factor complex KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.46629 BP_3 40.10 7.07 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF01363 Zinc-finger associated domain (zf-AD)//FYVE zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.4663 BP_3 8.00 0.73 823 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46632 BP_3 376.59 10.63 1999 478254836 ENN75072.1 973 1.9e-102 hypothetical protein YQE_08385, partial [Dendroctonus ponderosae] -- -- -- -- -- K16795 PAFAH1B2_3 platelet-activating factor acetylhydrolase IB subunit beta/gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16795 Q61206 484 4.0e-47 Platelet-activating factor acetylhydrolase IB subunit beta OS=Mus musculus GN=Pafah1b2 PE=1 SV=2 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.46633 BP_3 243.67 1.13 10726 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.46634 BP_3 396.19 2.85 6995 642928264 XP_969418.2 1644 1.1e-179 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q2NL14 660 5.5e-67 KAT8 regulatory NSL complex subunit 2 OS=Bos taurus GN=KANSL2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.46636 BP_3 72.33 1.11 3445 861616833 KMQ86423.1 1250 2.5e-134 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 498 1.7e-48 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF13683//PF00665//PF01165 Integrase core domain//Integrase core domain//Ribosomal protein S21 GO:0042254//GO:0015074//GO:0006412 ribosome biogenesis//DNA integration//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.46642 BP_3 703.84 14.70 2600 642928291 XP_008195520.1 2436 5.7e-272 PREDICTED: helicase SKI2W [Tribolium castaneum] 510904653 XM_004830813.1 55 3.13305e-17 Babesia equi DEAD/DEAH box helicase domain-containing protein (BEWA_006130) mRNA, complete cds K12599 SKI2, SKIV2L antiviral helicase SKI2 http://www.genome.jp/dbget-bin/www_bget?ko:K12599 Q15477 1385 1.7e-151 Helicase SKI2W OS=Homo sapiens GN=SKIV2L PE=1 SV=3 PF00787//PF04119 PX domain//Heat shock protein 9/12 GO:0006950 response to stress GO:0035091 phosphatidylinositol binding -- -- KOG0947 Cytoplasmic exosomal RNA helicase SKI2, DEAD-box superfamily Cluster-8309.46644 BP_3 217.95 1.82 6056 546685110 ERL94637.1 2013 1.5e-222 hypothetical protein D910_11912 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PCB5 1066 4.0e-114 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 PF06151 Trehalose receptor GO:0007607//GO:0050912//GO:0007187 obsolete taste perception//detection of chemical stimulus involved in sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4425 Uncharacterized conserved protein Cluster-8309.46646 BP_3 1969.58 13.33 7413 91076206 XP_972459.1 2763 2.0e-309 PREDICTED: KN motif and ankyrin repeat domain-containing protein 2 [Tribolium castaneum]>gi|270014552|gb|EFA11000.1| hypothetical protein TcasGA2_TC004585 [Tribolium castaneum] 759076887 XM_011349892.1 70 4.13022e-25 PREDICTED: Cerapachys biroi KN motif and ankyrin repeat domain-containing protein 2-like (LOC105285603), transcript variant X3, mRNA -- -- -- -- Q14678 663 2.6e-67 KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens GN=KANK1 PE=1 SV=3 PF13606//PF00628//PF07649//PF00130//PF00023//PF13939//PF01300//PF01096//PF02150 Ankyrin repeat//PHD-finger//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ankyrin repeat//Toxin TisB, type I toxin-antitoxin system//Telomere recombination//Transcription factor S-II (TFIIS)//RNA polymerases M/15 Kd subunit GO:0055114//GO:0035556//GO:0022611//GO:0006144//GO:0006351//GO:0006820//GO:0006206//GO:0009432 oxidation-reduction process//intracellular signal transduction//dormancy process//purine nucleobase metabolic process//transcription, DNA-templated//anion transport//pyrimidine nucleobase metabolic process//SOS response GO:0003899//GO:0003725//GO:0047134//GO:0008270//GO:0005253//GO:0005515//GO:0003677//GO:0003676 DNA-directed RNA polymerase activity//double-stranded RNA binding//protein-disulfide reductase activity//zinc ion binding//anion channel activity//protein binding//DNA binding//nucleic acid binding GO:0005887//GO:0005730 integral component of plasma membrane//nucleolus KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.46647 BP_3 365.00 12.77 1669 642927459 XP_968905.2 1207 1.2e-129 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q3SZJ4 799 1.0e-83 Prostaglandin reductase 1 OS=Bos taurus GN=PTGR1 PE=2 SV=1 PF01370//PF00208//PF00106//PF02826//PF00107 NAD dependent epimerase/dehydratase family//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//short chain dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Zinc-binding dehydrogenase GO:0006520//GO:0055114//GO:0008152 cellular amino acid metabolic process//oxidation-reduction process//metabolic process GO:0016491//GO:0051287//GO:0003824//GO:0050662 oxidoreductase activity//NAD binding//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.46648 BP_3 538.09 3.26 8239 91087319 XP_975585.1 1377 1.1e-148 PREDICTED: solute carrier family 46 member 3-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q5F4B8 256 4.6e-20 Solute carrier family 46 member 3 OS=Gallus gallus GN=SLC46A3 PE=2 SV=1 PF00608//PF02285//PF03869//PF07690 Adenoviral fibre protein (repeat/shaft region)//Cytochrome oxidase c subunit VIII//Arc-like DNA binding domain//Major Facilitator Superfamily GO:0015992//GO:0007155//GO:0055085//GO:0006123//GO:0009405//GO:0019062 proton transport//cell adhesion//transmembrane transport//mitochondrial electron transport, cytochrome c to oxygen//pathogenesis//virion attachment to host cell GO:0004129//GO:0003677 cytochrome-c oxidase activity//DNA binding GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.46650 BP_3 2952.88 125.15 1429 642934635 XP_008197747.1 237 3.1e-17 PREDICTED: uncharacterized protein LOC103314201 [Tribolium castaneum]>gi|270013491|gb|EFA09939.1| hypothetical protein TcasGA2_TC012092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46651 BP_3 21.07 0.70 1747 642934635 XP_008197747.1 196 2.1e-12 PREDICTED: uncharacterized protein LOC103314201 [Tribolium castaneum]>gi|270013491|gb|EFA09939.1| hypothetical protein TcasGA2_TC012092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46654 BP_3 670.82 7.79 4443 642928504 XP_008193818.1 3415 0.0e+00 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VGW4 1340 4.9e-146 Endoplasmic reticulum metallopeptidase 1 OS=Xenopus laevis GN=ermp1 PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.46659 BP_3 166.79 2.28 3812 307170013 EFN62483.1 873 1.5e-90 Transposable element P transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q7M3K2 476 6.5e-46 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46663 BP_3 46.35 1.72 1587 270013857 EFA10305.1 155 1.1e-07 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02297 Cytochrome oxidase c subunit VIb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0005739//GO:0045277 mitochondrion//respiratory chain complex IV -- -- Cluster-8309.46664 BP_3 323.73 3.96 4232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46665 BP_3 473.85 7.60 3295 642915652 XP_008190697.1 1571 1.5e-171 PREDICTED: integrin-alpha FG-GAP repeat-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- K09648 IMP2 mitochondrial inner membrane protease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09648 Q969R8 631 6.0e-64 Integrin-alpha FG-GAP repeat-containing protein 2 OS=Homo sapiens GN=ITFG2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1568 Mitochondrial inner membrane protease, subunit IMP2 Cluster-8309.46666 BP_3 3.74 0.36 793 270016407 EFA12853.1 455 8.9e-43 hypothetical protein TcasGA2_TC000150 [Tribolium castaneum] -- -- -- -- -- K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46667 BP_3 2260.73 25.70 4531 270012101 EFA08549.1 2607 1.5e-291 hypothetical protein TcasGA2_TC006204 [Tribolium castaneum] 642931168 XM_964110.3 418 0 PREDICTED: Tribolium castaneum protein tweety (LOC657663), mRNA -- -- -- -- Q9U6L4 1123 7.3e-121 Protein tweety OS=Drosophila melanogaster GN=tty PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46669 BP_3 117.00 4.66 1503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46670 BP_3 43.00 3.47 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46672 BP_3 23.00 14.28 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08465 Thymidine kinase from Herpesvirus C-terminal GO:0006230//GO:0006206 TMP biosynthetic process//pyrimidine nucleobase metabolic process GO:0004797//GO:0005524 thymidine kinase activity//ATP binding -- -- -- -- Cluster-8309.46673 BP_3 975.15 36.91 1565 642933298 XP_008197360.1 974 1.2e-102 PREDICTED: LOW QUALITY PROTEIN: mucin-17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46676 BP_3 20.12 0.38 2853 270007463 EFA03911.1 274 3.1e-21 hypothetical protein TcasGA2_TC014045 [Tribolium castaneum] -- -- -- -- -- K13163 MSL1 male-specific lethal 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13163 Q68DK7 136 1.3e-06 Male-specific lethal 1 homolog OS=Homo sapiens GN=MSL1 PE=1 SV=3 PF00558 Vpu protein GO:0019076//GO:0032801//GO:0006812 viral release from host cell//receptor catabolic process//cation transport GO:0005261 cation channel activity GO:0033644 host cell membrane -- -- Cluster-8309.46677 BP_3 415.00 11.22 2074 91078636 XP_968589.1 446 2.6e-41 PREDICTED: U6 snRNA-associated Sm-like protein LSm5 [Tribolium castaneum]>gi|270004060|gb|EFA00508.1| hypothetical protein TcasGA2_TC003372 [Tribolium castaneum] 242023982 XM_002432365.1 101 6.68402e-43 Pediculus humanus corporis conserved hypothetical protein, mRNA K12624 LSM5 U6 snRNA-associated Sm-like protein LSm5 http://www.genome.jp/dbget-bin/www_bget?ko:K12624 Q2HJH0 382 2.8e-35 U6 snRNA-associated Sm-like protein LSm5 OS=Bos taurus GN=LSM5 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG1775 U6 snRNA-associated Sm-like protein Cluster-8309.4668 BP_3 12.00 0.46 1541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46682 BP_3 2.67 0.52 539 546681790 ERL91816.1 221 8.3e-16 hypothetical protein D910_09141 [Dendroctonus ponderosae] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q9CXE6 156 1.2e-09 DNA repair protein XRCC3 OS=Mus musculus GN=Xrcc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1564 DNA repair protein RHP57 Cluster-8309.46689 BP_3 419.63 15.34 1610 642922662 XP_008193267.1 1027 8.5e-109 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q27589 806 1.5e-84 Cytochrome P450 4d2 OS=Drosophila melanogaster GN=Cyp4d2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.46690 BP_3 6.00 0.79 660 642922662 XP_008193267.1 356 2.2e-31 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K17953 CYP31A cytochrome P450, family 31, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17953 P29981 309 2.6e-27 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.46692 BP_3 19.37 0.67 1682 642922662 XP_008193267.1 1010 8.4e-107 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q27589 776 4.7e-81 Cytochrome P450 4d2 OS=Drosophila melanogaster GN=Cyp4d2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.46693 BP_3 611.16 11.09 2947 91092362 XP_971770.1 1234 1.6e-132 PREDICTED: midnolin-A [Tribolium castaneum]>gi|270015714|gb|EFA12162.1| hypothetical protein TcasGA2_TC002312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZWN4 381 5.2e-35 Midnolin-A OS=Xenopus laevis GN=midn-a PE=2 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46695 BP_3 21.00 2.25 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46698 BP_3 6.00 0.50 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46700 BP_3 362.84 3.75 4950 270013742 EFA10190.1 824 9.1e-85 hypothetical protein TcasGA2_TC012382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46703 BP_3 2202.46 30.68 3752 91088223 XP_973543.1 2732 3.9e-306 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X1 [Tribolium castaneum]>gi|270011823|gb|EFA08271.1| hypothetical protein TcasGA2_TC005902 [Tribolium castaneum] 645002819 XM_008209794.1 290 1.04964e-147 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X3, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 2284 1.4e-255 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.46706 BP_3 1760.81 17.49 5145 642933550 XP_008197466.1 3443 0.0e+00 PREDICTED: reversion-inducing cysteine-rich protein with Kazal motifs [Tribolium castaneum] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 1914 1.6e-212 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 PF07648//PF05375//PF00050//PF02130 Kazal-type serine protease inhibitor domain//Pacifastin inhibitor (LCMII)//Kazal-type serine protease inhibitor domain//Uncharacterized protein family UPF0054 GO:0006364 rRNA processing GO:0004222//GO:0030414//GO:0005515 metalloendopeptidase activity//peptidase inhibitor activity//protein binding -- -- -- -- Cluster-8309.46707 BP_3 134.76 1.17 5862 270007165 EFA03613.1 1442 2.4e-156 hypothetical protein TcasGA2_TC013701 [Tribolium castaneum] 642922583 XM_008195015.1 341 7.3382e-176 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X3, mRNA -- -- -- -- P55197 839 8.1e-88 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG0956 PHD finger protein AF10 Cluster-8309.46708 BP_3 15.38 1.34 847 642939420 XP_008200384.1 380 4.7e-34 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha isoform X1 [Tribolium castaneum]>gi|270016503|gb|EFA12949.1| hypothetical protein TcasGA2_TC005069 [Tribolium castaneum] -- -- -- -- -- K13711 PI4K2 phosphatidylinositol 4-kinase type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13711 Q6DCQ8 244 1.1e-19 Phosphatidylinositol 4-kinase type 2-beta OS=Xenopus laevis GN=pi4k2b PE=2 SV=1 PF14987//PF17050 NADH dehydrogenase 1 alpha subcomplex subunit 3//Altered inheritance of mitochondria 5 GO:0042407 cristae formation -- -- GO:0061617//GO:0005743//GO:0044284//GO:0005747 MICOS complex//mitochondrial inner membrane//mitochondrial crista junction//mitochondrial respiratory chain complex I KOG2381 Phosphatidylinositol 4-kinase Cluster-8309.46711 BP_3 21.47 0.46 2540 642919246 XP_008191792.1 900 7.2e-94 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 533 1.1e-52 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46713 BP_3 51.27 0.52 5062 478251563 ENN72025.1 1955 6.6e-216 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1Z8J0 1065 4.3e-114 CWF19-like protein 1 homolog OS=Drosophila melanogaster GN=CG7741 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.46714 BP_3 104.84 1.99 2832 91081405 XP_972749.1 1031 5.2e-109 PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|642920827|ref|XP_008192575.1| PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|270005174|gb|EFA01622.1| hypothetical protein TcasGA2_TC007191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ3 432 6.1e-41 T-complex protein 11-like protein 1 OS=Homo sapiens GN=TCP11L1 PE=1 SV=1 PF12689//PF03310 Acid Phosphatase//Caulimovirus DNA-binding protein -- -- GO:0016791//GO:0003677 phosphatase activity//DNA binding -- -- KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family Cluster-8309.46715 BP_3 230.50 3.59 3383 478252457 ENN72879.1 2104 2.3e-233 hypothetical protein YQE_10449, partial [Dendroctonus ponderosae] -- -- -- -- -- K09531 DNAJC11 DnaJ homolog subfamily C member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09531 Q5U458 1166 5.6e-126 DnaJ homolog subfamily C member 11 OS=Mus musculus GN=Dnajc11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0718 Molecular chaperone (DnaJ superfamily) Cluster-8309.46716 BP_3 341.09 5.93 3064 546683205 ERL93045.1 3551 0.0e+00 hypothetical protein D910_10347 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96JG6 1826 1.5e-202 Syndetin OS=Homo sapiens GN=CCDC132 PE=1 SV=3 PF05531//PF04048//PF08718 Nucleopolyhedrovirus P10 protein//Sec8 exocyst complex component specific domain//Glycolipid transfer protein (GLTP) GO:0015031//GO:0006904//GO:0046836 protein transport//vesicle docking involved in exocytosis//glycolipid transport GO:0051861//GO:0017089 glycolipid binding//glycolipid transporter activity GO:0000145//GO:0005737//GO:0019028 exocyst//cytoplasm//viral capsid KOG2939 Uncharacterized conserved protein Cluster-8309.46718 BP_3 187.05 7.74 1457 270004864 EFA01312.1 2091 3.2e-232 baboon, partial [Tribolium castaneum] 589944031 XM_006984651.1 98 2.16876e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 P36897 1480 9.4e-163 TGF-beta receptor type-1 OS=Homo sapiens GN=TGFBR1 PE=1 SV=1 PF08515//PF00069//PF01064//PF07714 Transforming growth factor beta type I GS-motif//Protein kinase domain//Activin types I and II receptor domain//Protein tyrosine kinase GO:0007178//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004675//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.46719 BP_3 5.00 4.97 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46720 BP_3 32.00 8.05 483 826449982 XP_012532058.1 135 6.9e-06 PREDICTED: TGF-beta receptor type-1 isoform X2 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064 Activin types I and II receptor domain GO:0016310//GO:0009069//GO:0007178 phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.46721 BP_3 6.00 0.67 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46722 BP_3 69.87 1.61 2387 270004864 EFA01312.1 2073 6.5e-230 baboon, partial [Tribolium castaneum] 589944031 XM_006984651.1 98 3.58714e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 P36897 1473 1.0e-161 TGF-beta receptor type-1 OS=Homo sapiens GN=TGFBR1 PE=1 SV=1 PF07714//PF01064//PF00069//PF08515//PF02790 Protein tyrosine kinase//Activin types I and II receptor domain//Protein kinase domain//Transforming growth factor beta type I GS-motif//Cytochrome C oxidase subunit II, transmembrane domain GO:0009069//GO:0006468//GO:0016310//GO:0007178//GO:0022900 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//electron transport chain GO:0005524//GO:0004672//GO:0004675 ATP binding//protein kinase activity//transmembrane receptor protein serine/threonine kinase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.46724 BP_3 5.00 0.47 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46725 BP_3 18.11 0.73 1484 642915222 XP_008190529.1 1973 1.6e-218 PREDICTED: TGF-beta receptor type-1 isoform X1 [Tribolium castaneum] 589944031 XM_006984651.1 98 2.20994e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 O46680 1455 7.6e-160 TGF-beta receptor type-1 OS=Bos taurus GN=TGFBR1 PE=2 SV=1 PF08515//PF01064//PF00069//PF07714 Transforming growth factor beta type I GS-motif//Activin types I and II receptor domain//Protein kinase domain//Protein tyrosine kinase GO:0007178//GO:0016310//GO:0006468//GO:0009069 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.46729 BP_3 279.69 3.08 4663 307173098 EFN64217.1 1138 3.3e-121 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 568 1.7e-56 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF00619//PF13851//PF04977//PF05485 Caspase recruitment domain//Growth-arrest specific micro-tubule binding//Septum formation initiator//THAP domain GO:0007049//GO:0048870//GO:0042981 cell cycle//cell motility//regulation of apoptotic process GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.46731 BP_3 650.72 11.48 3024 768419593 XP_011550521.1 1889 1.8e-208 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [Plutella xylostella] 695538883 XM_009544325.1 56 1.01444e-17 Heterobasidion irregulare TC 32-1 hypothetical protein mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 A4FV68 1632 4.6e-180 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Bos taurus GN=PPP2R5E PE=1 SV=1 PF01603 Protein phosphatase 2A regulatory B subunit (B56 family) GO:0007165 signal transduction GO:0008601 protein phosphatase type 2A regulator activity GO:0000159 protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.46732 BP_3 250.03 2.38 5347 642915949 XP_967806.3 974 4.0e-102 PREDICTED: protein halfway isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 475 1.2e-45 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46733 BP_3 291.98 4.11 3714 91076832 XP_974636.1 3605 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 168 6.8549e-80 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 O08648 670 2.0e-68 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0000166//GO:0005524 protein kinase activity//nucleotide binding//ATP binding -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.46734 BP_3 160.20 3.22 2688 642929118 XP_008195696.1 834 3.4e-86 PREDICTED: uncharacterized protein LOC100142378 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42893 530 2.5e-52 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.46735 BP_3 559.55 4.88 5815 546677823 ERL88580.1 3317 0.0e+00 hypothetical protein D910_05965 [Dendroctonus ponderosae] 562831337 XM_006145090.1 42 1.1892e-09 PREDICTED: Tupaia chinensis tripartite motif containing 24 (TRIM24), mRNA K08883 TRIM33, TIF1G tripartite motif-containing protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K08883 Q56R14 487 5.3e-47 E3 ubiquitin-protein ligase TRIM33 OS=Xenopus laevis GN=trim33 PE=1 SV=1 PF00439//PF13639//PF00628//PF14634//PF00643//PF00097//PF01361 Bromodomain//Ring finger domain//PHD-finger//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger)//Tautomerase enzyme GO:0006725 cellular aromatic compound metabolic process GO:0046872//GO:0005515//GO:0016853//GO:0008270 metal ion binding//protein binding//isomerase activity//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.46736 BP_3 222.00 3.35 3484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08025 Spider antimicrobial peptide GO:0019836 hemolysis by symbiont of host erythrocytes -- -- GO:0005576 extracellular region -- -- Cluster-8309.46737 BP_3 42.10 0.45 4755 642925990 XP_008194721.1 3148 0.0e+00 PREDICTED: DNA repair and recombination protein RAD54-like [Tribolium castaneum] -- -- -- -- -- K10875 RAD54L, RAD54 DNA repair and recombination protein RAD54 and RAD54-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K10875 Q92698 2264 3.8e-253 DNA repair and recombination protein RAD54-like OS=Homo sapiens GN=RAD54L PE=1 SV=2 PF00176//PF01484//PF04851 SNF2 family N-terminal domain//Nematode cuticle collagen N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0005524//GO:0042302 DNA binding//hydrolase activity//ATP binding//structural constituent of cuticle -- -- KOG0390 DNA repair protein, SNF2 family Cluster-8309.46738 BP_3 100.39 0.57 8851 642937185 XP_008198729.1 2693 3.1e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 4.76391e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 3.0e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF11744//PF05033//PF13606//PF02068//PF00856//PF05192//PF00023//PF00995 Aluminium activated malate transporter//Pre-SET motif//Ankyrin repeat//Plant PEC family metallothionein//SET domain//MutS domain III//Ankyrin repeat//Sec1 family GO:0006298//GO:0016192//GO:0034968//GO:0015743//GO:0006904//GO:0006479//GO:0006554 mismatch repair//vesicle-mediated transport//histone lysine methylation//malate transport//vesicle docking involved in exocytosis//protein methylation//lysine catabolic process GO:0018024//GO:0005524//GO:0005515//GO:0030983//GO:0008270 histone-lysine N-methyltransferase activity//ATP binding//protein binding//mismatched DNA binding//zinc ion binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.46744 BP_3 31.82 0.41 4012 156564355 NP_001096056.1 2228 1.2e-247 aromatic-L-amino-acid decarboxylase [Tribolium castaneum]>gi|155675828|gb|ABU25222.1| dopa decarboxylase [Tribolium castaneum] 332373577 BT126968.1 368 0 Dendroctonus ponderosae clone DPO1325_L24 unknown mRNA K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P05031 1950 8.2e-217 Aromatic-L-amino-acid decarboxylase OS=Drosophila melanogaster GN=Ddc PE=1 SV=4 PF05889//PF00282//PF01212//PF00155 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//Aminotransferase class I and II GO:0019752//GO:0006570//GO:0042432//GO:0009821//GO:0006520//GO:0009058//GO:0006568//GO:0006558//GO:0006547 carboxylic acid metabolic process//tyrosine metabolic process//indole biosynthetic process//alkaloid biosynthetic process//cellular amino acid metabolic process//biosynthetic process//tryptophan metabolic process//L-phenylalanine metabolic process//histidine metabolic process GO:0030170//GO:0016831//GO:0016740//GO:0016829//GO:0004058 pyridoxal phosphate binding//carboxy-lyase activity//transferase activity//lyase activity//aromatic-L-amino-acid decarboxylase activity -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.46745 BP_3 287.00 15.97 1158 478253972 ENN74264.1 285 6.7e-23 hypothetical protein YQE_09236, partial [Dendroctonus ponderosae]>gi|546674823|gb|ERL86109.1| hypothetical protein D910_03523 [Dendroctonus ponderosae] 749731967 XM_011139388.1 34 6.48064e-06 PREDICTED: Harpegnathos saltator UPF0547 protein C16orf87-like (LOC105182147), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF07882//PF07851//PF08070 L-fucose isomerase, second N-terminal domain//TMPIT-like protein//DTHCT (NUC029) region GO:0006013//GO:0006265//GO:0006000//GO:0006004 mannose metabolic process//DNA topological change//fructose metabolic process//fucose metabolic process GO:0003918//GO:0005524//GO:0003677//GO:0008736 DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding//DNA binding//L-fucose isomerase activity GO:0005737//GO:0005634//GO:0016021 cytoplasm//nucleus//integral component of membrane -- -- Cluster-8309.46746 BP_3 532.31 8.05 3479 642928007 XP_008200118.1 1675 1.3e-183 PREDICTED: solute carrier family 35, member F5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15289 SLC35F5 solute carrier family 35, member F5 http://www.genome.jp/dbget-bin/www_bget?ko:K15289 A6QL92 863 7.9e-91 Solute carrier family 35 member F5 OS=Bos taurus GN=SLC35F5 PE=2 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG2765 Predicted membrane protein Cluster-8309.46747 BP_3 124.46 0.67 9250 642918833 XP_008191605.1 7409 0.0e+00 PREDICTED: myotubularin-related protein 13 isoform X4 [Tribolium castaneum]>gi|270005687|gb|EFA02135.1| hypothetical protein TcasGA2_TC007785 [Tribolium castaneum] 642918832 XM_008193383.1 1305 0 PREDICTED: Tribolium castaneum myotubularin-related protein 13 (LOC659622), transcript variant X4, mRNA K18061 SBF1_2, MTMR5_13 myotubularin-related protein 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K18061 Q86WG5 2943 0.0e+00 Myotubularin-related protein 13 OS=Homo sapiens GN=SBF2 PE=1 SV=1 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0016311 intracellular signal transduction//dephosphorylation GO:0005543//GO:0046872//GO:0016791 phospholipid binding//metal ion binding//phosphatase activity GO:0005622 intracellular KOG1090 Predicted dual-specificity phosphatase Cluster-8309.46748 BP_3 627.27 20.33 1779 646709836 KDR15525.1 1383 4.9e-150 Vacuolar protein sorting-associated protein 26B-like [Zootermopsis nevadensis] 545849340 XM_003482653.2 172 1.94305e-82 PREDICTED: Sus scrofa vacuolar protein sorting-associated protein 26B-like (LOC100738900), mRNA K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q9W552 1291 9.5e-141 Vacuolar protein sorting-associated protein 26 OS=Drosophila melanogaster GN=Vps26 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.46750 BP_3 137.88 4.71 1703 189235363 XP_001808147.1 741 1.3e-75 PREDICTED: uncharacterized protein LOC100142009 [Tribolium castaneum]>gi|270003618|gb|EFA00066.1| hypothetical protein TcasGA2_TC002880 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46752 BP_3 949.65 8.84 5472 270016078 EFA12526.1 1426 1.6e-154 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] 118441617 CR925768.9 53 8.5865e-16 Zebrafish DNA sequence from clone DKEY-20L4 in linkage group 12, complete sequence -- -- -- -- P0CT34 848 6.8e-89 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF02793//PF00665 Hormone receptor domain//Integrase core domain GO:0015074//GO:0007186 DNA integration//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.46753 BP_3 96.00 15.01 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46754 BP_3 414.24 8.69 2589 91091956 XP_968337.1 3381 0.0e+00 PREDICTED: exocyst complex component 6 [Tribolium castaneum]>gi|270000776|gb|EEZ97223.1| hypothetical protein TcasGA2_TC011021 [Tribolium castaneum] 571522972 XM_393572.5 71 3.97877e-26 PREDICTED: Apis mellifera exocyst complex component 6 (sec15), transcript variant 2, mRNA -- -- -- -- Q9VDE6 1952 3.1e-217 Exocyst complex component 6 OS=Drosophila melanogaster GN=sec15 PE=1 SV=1 PF04048//PF04091//PF01207 Sec8 exocyst complex component specific domain//Exocyst complex subunit Sec15-like//Dihydrouridine synthase (Dus) GO:0006904//GO:0055114//GO:0015031//GO:0008033 vesicle docking involved in exocytosis//oxidation-reduction process//protein transport//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity GO:0000145 exocyst KOG2176 Exocyst complex, subunit SEC15 Cluster-8309.46756 BP_3 527.07 15.40 1941 478252064 ENN72495.1 1626 3.6e-178 hypothetical protein YQE_10836, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VWN5 1225 4.7e-133 Protein FAM188A homolog OS=Drosophila melanogaster GN=CG7332 PE=1 SV=1 PF13499//PF13405//PF00036 EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG2871 Uncharacterized conserved protein Cluster-8309.46758 BP_3 36.64 0.47 4088 642929686 XP_008195936.1 1124 1.2e-119 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] 462360465 APGK01029384.1 79 2.25365e-30 Dendroctonus ponderosae Seq01029394, whole genome shotgun sequence -- -- -- -- Q02308 257 1.7e-20 Protein hairless OS=Drosophila melanogaster GN=H PE=1 SV=2 PF07706 Aminotransferase ubiquitination site GO:0006536//GO:0009821//GO:0009074//GO:0006571//GO:0000162//GO:0009094//GO:0006103 glutamate metabolic process//alkaloid biosynthetic process//aromatic amino acid family catabolic process//tyrosine biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process//2-oxoglutarate metabolic process GO:0030170//GO:0004838 pyridoxal phosphate binding//L-tyrosine:2-oxoglutarate aminotransferase activity -- -- -- -- Cluster-8309.46759 BP_3 20.00 0.35 3028 641672830 XP_008186079.1 175 1.0e-09 PREDICTED: zinc finger protein 674-like isoform X1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.4676 BP_3 2.00 0.31 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46761 BP_3 56.93 0.60 4870 242018392 XP_002429661.1 498 5.7e-47 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 383 5.0e-35 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF05279//PF13465//PF00096 Aspartyl beta-hydroxylase N-terminal region//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0016020 membrane -- -- Cluster-8309.46762 BP_3 214.48 2.99 3746 91089279 XP_970539.1 1682 2.2e-184 PREDICTED: serine/threonine-protein kinase unc-51 isoform X1 [Tribolium castaneum]>gi|270011454|gb|EFA07902.1| hypothetical protein TcasGA2_TC005477 [Tribolium castaneum] 820865549 XM_003698790.2 61 2.09284e-20 PREDICTED: Apis florea serine/threonine-protein kinase unc-51 (LOC100864929), transcript variant X1, mRNA K08269 ULK1_2_3, ATG1 serine/threonine-protein kinase ULK/ATG1 http://www.genome.jp/dbget-bin/www_bget?ko:K08269 Q8IYT8 967 7.4e-103 Serine/threonine-protein kinase ULK2 OS=Homo sapiens GN=ULK2 PE=1 SV=3 PF06293//PF00069//PF07714//PF12063 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Domain of unknown function (DUF3543) GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674//GO:0000166//GO:0016773 ATP binding//protein kinase activity//protein serine/threonine kinase activity//nucleotide binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0595 Serine/threonine-protein kinase involved in autophagy Cluster-8309.46763 BP_3 46.23 0.83 2988 91089279 XP_970539.1 1916 1.3e-211 PREDICTED: serine/threonine-protein kinase unc-51 isoform X1 [Tribolium castaneum]>gi|270011454|gb|EFA07902.1| hypothetical protein TcasGA2_TC005477 [Tribolium castaneum] 820865549 XM_003698790.2 61 1.66524e-20 PREDICTED: Apis florea serine/threonine-protein kinase unc-51 (LOC100864929), transcript variant X1, mRNA K08269 ULK1_2_3, ATG1 serine/threonine-protein kinase ULK/ATG1 http://www.genome.jp/dbget-bin/www_bget?ko:K08269 Q8IYT8 967 5.9e-103 Serine/threonine-protein kinase ULK2 OS=Homo sapiens GN=ULK2 PE=1 SV=3 PF07714//PF12063//PF06293//PF00069 Protein tyrosine kinase//Domain of unknown function (DUF3543)//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0004672//GO:0016772//GO:0016773 ATP binding//protein serine/threonine kinase activity//protein kinase activity//transferase activity, transferring phosphorus-containing groups//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0595 Serine/threonine-protein kinase involved in autophagy Cluster-8309.46764 BP_3 32.08 0.48 3521 478256132 ENN76331.1 1942 1.5e-214 hypothetical protein YQE_07294, partial [Dendroctonus ponderosae]>gi|546675874|gb|ERL86979.1| hypothetical protein D910_04382 [Dendroctonus ponderosae] 157114192 XM_001652155.1 199 3.80003e-97 Aedes aegypti AAEL006730-RA partial mRNA K04407 MAP4K4, HGK mitogen-activated protein kinase kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04407 Q23356 1468 5.6e-161 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF12537 The Golgi pH Regulator (GPHR) Family N-terminal -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.46765 BP_3 115.98 1.99 3102 91088055 XP_967186.1 1467 1.6e-159 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 111 2.77387e-48 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q2NL29 1243 6.1e-135 Inositol-3-phosphate synthase 1 OS=Bos taurus GN=ISYNA1 PE=2 SV=1 PF13762//PF07994//PF13912 Mitochondrial splicing apparatus component//Myo-inositol-1-phosphate synthase//C2H2-type zinc finger GO:0006021//GO:0000372//GO:0019872//GO:0008654 inositol biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//phospholipid biosynthetic process GO:0004512//GO:0046872//GO:0000166 inositol-3-phosphate synthase activity//metal ion binding//nucleotide binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.46766 BP_3 252.70 2.59 4997 642928750 XP_008199767.1 3233 0.0e+00 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] 642928749 XM_008201545.1 659 0 PREDICTED: Tribolium castaneum uncharacterized LOC663132 (LOC663132), mRNA -- -- -- -- Q9UPX0 212 3.5e-15 Protein turtle homolog B OS=Homo sapiens GN=IGSF9B PE=2 SV=2 PF00001//PF13895 7 transmembrane receptor (rhodopsin family)//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.46768 BP_3 1119.31 20.55 2917 642915551 XP_008190663.1 1295 1.3e-139 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 71 4.48679e-26 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 2.3e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076//PF01480 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PWI domain GO:0006397 mRNA processing GO:0003676 nucleic acid binding -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.46773 BP_3 87.83 1.13 4032 546684171 ERL93876.1 1173 2.5e-125 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P57775 470 3.4e-45 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF00646//PF01442//PF00400//PF15966//PF03357//PF12937 F-box domain//Apolipoprotein A1/A4/E domain//WD domain, G-beta repeat//F-box//Snf7//F-box-like GO:0042157//GO:0007034//GO:0006869 lipoprotein metabolic process//vacuolar transport//lipid transport GO:0008289//GO:0005515 lipid binding//protein binding GO:0005576 extracellular region KOG2911 Uncharacterized conserved protein Cluster-8309.46775 BP_3 100.41 1.76 3041 91084211 XP_968214.1 750 2.1e-76 PREDICTED: transcriptional adapter 3 [Tribolium castaneum]>gi|270008765|gb|EFA05213.1| hypothetical protein TcasGA2_TC015353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66IZ5 282 1.6e-23 Transcriptional adapter 3-B OS=Xenopus laevis GN=tada3-b PE=2 SV=1 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.46776 BP_3 1044.56 5.94 8768 189238003 XP_969912.2 3006 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925068|ref|XP_008194156.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925070|ref|XP_008194157.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|270008050|gb|EFA04498.1| hypothetical protein TcasGA2_TC014806 [Tribolium castaneum] 642925074 XM_008195937.1 248 5.48987e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 252 1.4e-19 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF04988//PF00096//PF13465//PF02196//PF05792//PF00715 A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain//Raf-like Ras-binding domain//Candida agglutinin-like (ALS)//Interleukin 2 GO:0008283//GO:0007165//GO:0040007//GO:0007155//GO:0006955 cell proliferation//signal transduction//growth//cell adhesion//immune response GO:0005057//GO:0003677//GO:0008083//GO:0046872//GO:0005134 receptor signaling protein activity//DNA binding//growth factor activity//metal ion binding//interleukin-2 receptor binding GO:0005634//GO:0005893//GO:0005576 nucleus//interleukin-2 receptor complex//extracellular region -- -- Cluster-8309.46779 BP_3 312.28 15.82 1243 642919467 XP_008191881.1 497 1.9e-47 PREDICTED: polyprenol reductase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLP9 326 5.2e-29 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1640 Predicted steroid reductase Cluster-8309.46780 BP_3 11.40 4.42 415 270006525 EFA02973.1 275 3.5e-22 hypothetical protein TcasGA2_TC030714, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46781 BP_3 3249.39 18.01 8989 642937658 XP_008198888.1 6936 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 14 [Tribolium castaneum] 157132702 XM_001662569.1 146 2.83078e-67 Aedes aegypti AAEL012490-RA partial mRNA K15156 MED14, RGR1 mediator of RNA polymerase II transcription subunit 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15156 Q16U49 4416 0.0e+00 Mediator of RNA polymerase II transcription subunit 14 OS=Aedes aegypti GN=MED14 PE=3 SV=2 PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1875 Thyroid hormone receptor-associated coactivator complex component (TRAP170) Cluster-8309.46784 BP_3 164.00 26.50 590 642926014 XP_008194728.1 467 2.7e-44 PREDICTED: ATP-citrate synthase isoform X1 [Tribolium castaneum]>gi|642926016|ref|XP_008194729.1| PREDICTED: ATP-citrate synthase isoform X1 [Tribolium castaneum] 50540365 NM_001002649.1 42 1.14486e-10 Danio rerio ATP citrate lyase a (aclya), mRNA >gnl|BL_ORD_ID|2650124 Danio rerio ATP citrate lyase, mRNA (cDNA clone MGC:92008 IMAGE:7043656), complete cds K01648 ACLY ATP citrate (pro-S)-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01648 Q32PF2 295 9.8e-26 ATP-citrate synthase OS=Bos taurus GN=ACLY PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1254 ATP-citrate lyase Cluster-8309.46785 BP_3 195.43 30.65 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46786 BP_3 20.92 0.39 2901 546683632 ERL93420.1 1145 3.2e-122 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 P57095 334 1.4e-29 Axin-2 OS=Danio rerio GN=axin2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46789 BP_3 2292.55 31.87 3759 91077592 XP_973319.1 1821 1.7e-200 PREDICTED: decaprenyl-diphosphate synthase subunit 1 [Tribolium castaneum] 645030079 XM_008211983.1 197 5.25135e-96 PREDICTED: Nasonia vitripennis decaprenyl-diphosphate synthase subunit 1 (LOC100118369), transcript variant X4, mRNA K12504 PDSS1 decaprenyl-diphosphate synthase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12504 Q5T2R2 916 6.1e-97 Decaprenyl-diphosphate synthase subunit 1 OS=Homo sapiens GN=PDSS1 PE=1 SV=1 PF01783//PF00348 Ribosomal L32p protein family//Polyprenyl synthetase GO:0042254//GO:0008299//GO:0006412 ribosome biogenesis//isoprenoid biosynthetic process//translation GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.46791 BP_3 34.04 0.50 3604 91084515 XP_967225.1 751 1.9e-76 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891//GO:0003723 endoribonuclease activity, producing 5'-phosphomonoesters//RNA binding -- -- -- -- Cluster-8309.46793 BP_3 1495.46 25.32 3138 642917797 XP_008191290.1 2396 3.0e-267 PREDICTED: NAD-dependent histone deacetylase Sir2 [Tribolium castaneum]>gi|270003357|gb|EEZ99804.1| hypothetical protein TcasGA2_TC002584 [Tribolium castaneum] -- -- -- -- -- K11411 SIRT1, SIR2L1 NAD-dependent deacetylase sirtuin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11411 Q9VK34 1115 4.3e-120 NAD-dependent histone deacetylase Sir2 OS=Drosophila melanogaster GN=Sir2 PE=1 SV=1 PF04574//PF00205//PF02146 Protein of unknown function (DUF592)//Thiamine pyrophosphate enzyme, central domain//Sir2 family GO:0006355//GO:0006807//GO:0006476//GO:0006342 regulation of transcription, DNA-templated//nitrogen compound metabolic process//protein deacetylation//chromatin silencing GO:0008270//GO:0030976//GO:0000287//GO:0016811//GO:0017136//GO:0070403//GO:0051287 zinc ion binding//thiamine pyrophosphate binding//magnesium ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//NAD-dependent histone deacetylase activity//NAD+ binding//NAD binding GO:0000118 histone deacetylase complex KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family) Cluster-8309.46794 BP_3 1321.06 13.15 5133 270013169 EFA09617.1 2364 2.5e-263 hypothetical protein TcasGA2_TC011738 [Tribolium castaneum] 195495540 XM_002095275.1 180 2.02741e-86 Drosophila yakuba GE19764 (Dyak\GE19764), partial mRNA K08819 CDK12_13 cyclin-dependent kinase 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K08819 Q9VP22 1822 7.3e-202 Cyclin-dependent kinase 12 OS=Drosophila melanogaster GN=Cdk12 PE=1 SV=1 PF08272//PF00069//PF03092//PF00876//PF04505//PF07714 Topoisomerase I zinc-ribbon-like//Protein kinase domain//BT1 family//Innexin//Interferon-induced transmembrane protein//Protein tyrosine kinase GO:0006468//GO:0006810//GO:0006265//GO:0009607 protein phosphorylation//transport//DNA topological change//response to biotic stimulus GO:0005524//GO:0003677//GO:0004672//GO:0003918 ATP binding//DNA binding//protein kinase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0016021//GO:0005921//GO:0005694 integral component of membrane//gap junction//chromosome KOG0600 Cdc2-related protein kinase Cluster-8309.46795 BP_3 10.21 0.55 1192 270007759 EFA04207.1 734 6.0e-75 hypothetical protein TcasGA2_TC014456 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NM28 188 5.0e-13 Zinc finger protein 92 homolog OS=Homo sapiens GN=ZFP92 PE=2 SV=3 PF07776//PF13912//PF01155//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006464 cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.46797 BP_3 33.77 0.52 3433 91080655 XP_974603.1 512 9.5e-49 PREDICTED: post-GPI attachment to proteins factor 2 [Tribolium castaneum]>gi|270005499|gb|EFA01947.1| hypothetical protein TcasGA2_TC007562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UHJ9 296 4.4e-25 Post-GPI attachment to proteins factor 2 OS=Homo sapiens GN=PGAP2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3979 FGF receptor activating protein 1 Cluster-8309.46799 BP_3 239.21 1.82 6642 642930492 XP_008196426.1 2252 3.2e-250 PREDICTED: CLIP-associating protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 867 5.2e-91 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF02985//PF03153//PF12844//PF01528 HEAT repeat//Transcription factor IIA, alpha/beta subunit//Helix-turn-helix domain//Herpesvirus glycoprotein M GO:0006367 transcription initiation from RNA polymerase II promoter GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005672//GO:0016020 transcription factor TFIIA complex//membrane -- -- Cluster-8309.46800 BP_3 284.00 6.53 2388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46802 BP_3 302.49 6.24 2630 642932900 XP_008197178.1 2035 1.8e-225 PREDICTED: carboxypeptidase M isoform X1 [Tribolium castaneum] 170072561 XM_001870172.1 158 1.7524e-74 Culex quinquefasciatus carboxypeptidase D, mRNA K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q5RFD6 991 8.6e-106 Carboxypeptidase M OS=Pongo abelii GN=CPM PE=2 SV=1 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008270//GO:0016788//GO:0004181 zinc ion binding//hydrolase activity, acting on ester bonds//metallocarboxypeptidase activity -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.46804 BP_3 552.59 10.71 2778 642932902 XP_008197179.1 1991 2.4e-220 PREDICTED: carboxypeptidase M isoform X2 [Tribolium castaneum] 170072561 XM_001870172.1 158 1.85108e-74 Culex quinquefasciatus carboxypeptidase D, mRNA K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 993 5.3e-106 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF00246//PF04952 Zinc carboxypeptidase//Succinylglutamate desuccinylase / Aspartoacylase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004181//GO:0008270//GO:0016788 metallocarboxypeptidase activity//zinc ion binding//hydrolase activity, acting on ester bonds -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.46805 BP_3 24.66 0.40 3264 642932902 XP_008197179.1 1991 2.9e-220 PREDICTED: carboxypeptidase M isoform X2 [Tribolium castaneum] 170072561 XM_001870172.1 158 2.17918e-74 Culex quinquefasciatus carboxypeptidase D, mRNA K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 993 6.2e-106 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF00246//PF04952 Zinc carboxypeptidase//Succinylglutamate desuccinylase / Aspartoacylase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0004181//GO:0016788//GO:0008270 metallocarboxypeptidase activity//hydrolase activity, acting on ester bonds//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.46809 BP_3 4.00 23.68 258 546678141 ERL88850.1 161 3.6e-09 hypothetical protein D910_06232 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46810 BP_3 109.33 6.42 1113 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46811 BP_3 107.51 8.29 917 642934441 XP_008197664.1 1106 3.4e-118 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X3 [Tribolium castaneum] 242013552 XM_002427424.1 112 2.22255e-49 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K11728 BPTF, E(bx) nucleosome-remodeling factor subunit BPTF http://www.genome.jp/dbget-bin/www_bget?ko:K11728 Q9W0T1 699 2.2e-72 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00628//PF16866//PF00108//PF13639 PHD-finger//PHD-finger//Thiolase, N-terminal domain//Ring finger domain GO:0008152 metabolic process GO:0008270//GO:0005515//GO:0016747 zinc ion binding//protein binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.46812 BP_3 14.63 5.34 423 514683686 XP_004989424.1 217 1.9e-15 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- O54963 170 2.2e-11 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF04988//PF00096//PF13465//PF02150 A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.46814 BP_3 79.00 4.92 1065 642923174 XP_008193640.1 404 9.9e-37 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V877 246 8.5e-20 Kinesin-like protein subito OS=Drosophila melanogaster GN=sub PE=1 SV=1 PF00225//PF01146 Kinesin motor domain//Caveolin GO:0007018//GO:0007017//GO:0070836 microtubule-based movement//microtubule-based process//caveola assembly GO:0003777//GO:0005524//GO:0008017 microtubule motor activity//ATP binding//microtubule binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG0242 Kinesin-like protein Cluster-8309.46815 BP_3 25.49 1.43 1150 752860623 XP_011252895.1 465 9.0e-44 PREDICTED: putative uncharacterized protein FLJ37770 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q3ZCU0 248 5.4e-20 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46817 BP_3 99.29 2.08 2598 642915296 XP_008190559.1 391 7.7e-35 PREDICTED: signal recognition particle 9 kDa protein [Tribolium castaneum]>gi|270004979|gb|EFA01427.1| hypothetical protein TcasGA2_TC030568 [Tribolium castaneum] -- -- -- -- -- K03109 SRP9 signal recognition particle subunit SRP9 http://www.genome.jp/dbget-bin/www_bget?ko:K03109 Q9VSC1 231 1.1e-17 Signal recognition particle 9 kDa protein OS=Drosophila melanogaster GN=Srp9 PE=3 SV=1 -- -- GO:0045900//GO:0006614 negative regulation of translational elongation//SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3465 Signal recognition particle, subunit Srp9 Cluster-8309.46820 BP_3 168.00 1.38 6147 642934158 XP_968636.2 633 1.6e-62 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 378 2.4e-34 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151//PF01805 GNS1/SUR4 family//Surp module GO:0006396 RNA processing GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.46823 BP_3 5.00 0.37 945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46824 BP_3 48.02 0.41 5895 642937978 XP_008199153.1 4516 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 76 1.51611e-28 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 2441 1.4e-273 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00005//PF03193//PF04310//PF06414//PF13304//PF00352//PF00448 ABC transporter//Protein of unknown function, DUF258//MukB N-terminal//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//Transcription factor TFIID (or TATA-binding protein, TBP)//SRP54-type protein, GTPase domain GO:0006352//GO:0007059//GO:0030261//GO:0006614 DNA-templated transcription, initiation//chromosome segregation//chromosome condensation//SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0016887//GO:0016301//GO:0005524//GO:0003677//GO:0003924 GTP binding//ATPase activity//kinase activity//ATP binding//DNA binding//GTPase activity GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.46826 BP_3 861.53 5.41 7969 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 201 6.684e-98 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF00097//PF17122//PF14634//PF02148//PF02723//PF12678//PF00569//PF00443//PF12861//PF01165//PF00637//PF13639//PF05680 Zinc finger, C3HC4 type (RING finger)//Zinc-finger//zinc-RING finger domain//Zn-finger in ubiquitin-hydrolases and other protein//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//Zinc finger, ZZ type//Ubiquitin carboxyl-terminal hydrolase//Anaphase-promoting complex subunit 11 RING-H2 finger//Ribosomal protein S21//Region in Clathrin and VPS//Ring finger domain//ATP synthase E chain GO:0016192//GO:0006886//GO:0015992//GO:0042254//GO:0016579//GO:0016567//GO:0006412//GO:0015986 vesicle-mediated transport//intracellular protein transport//proton transport//ribosome biogenesis//protein deubiquitination//protein ubiquitination//translation//ATP synthesis coupled proton transport GO:0036459//GO:0008270//GO:0003735//GO:0015078//GO:0004842//GO:0005515//GO:0046872 ubiquitinyl hydrolase activity//zinc ion binding//structural constituent of ribosome//hydrogen ion transmembrane transporter activity//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005840//GO:0005680//GO:0000276//GO:0016020 ribosome//anaphase-promoting complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//membrane KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.46827 BP_3 540.33 8.80 3251 478263518 ENN81868.1 2723 3.8e-305 hypothetical protein YQE_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68EI3 1268 8.1e-138 Cytosolic carboxypeptidase-like protein 5 OS=Danio rerio GN=agbl5 PE=2 SV=1 PF04828//PF00246//PF07776//PF04952//PF05656 Glutathione-dependent formaldehyde-activating enzyme//Zinc carboxypeptidase//Zinc-finger associated domain (zf-AD)//Succinylglutamate desuccinylase / Aspartoacylase family//Protein of unknown function (DUF805) GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016788//GO:0008270//GO:0016846//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//carbon-sulfur lyase activity//metallocarboxypeptidase activity GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3641 Zinc carboxypeptidase Cluster-8309.46828 BP_3 511.66 5.97 4425 478263518 ENN81868.1 2311 3.0e-257 hypothetical protein YQE_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68EI3 1268 1.1e-137 Cytosolic carboxypeptidase-like protein 5 OS=Danio rerio GN=agbl5 PE=2 SV=1 PF04828//PF00246//PF07776//PF05656//PF04952 Glutathione-dependent formaldehyde-activating enzyme//Zinc carboxypeptidase//Zinc-finger associated domain (zf-AD)//Protein of unknown function (DUF805)//Succinylglutamate desuccinylase / Aspartoacylase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004181//GO:0016846//GO:0008270//GO:0016788 metallocarboxypeptidase activity//carbon-sulfur lyase activity//zinc ion binding//hydrolase activity, acting on ester bonds GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3641 Zinc carboxypeptidase Cluster-8309.46829 BP_3 12.34 0.37 1910 270011957 EFA08405.1 805 5.6e-83 hypothetical protein TcasGA2_TC006052 [Tribolium castaneum] -- -- -- -- -- K04710 CERS ceramide synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K04710 Q8C172 470 1.6e-45 Ceramide synthase 6 OS=Mus musculus GN=Cers6 PE=1 SV=1 PF03798//PF12766 TLC domain//Pyridoxamine 5'-phosphate oxidase -- -- GO:0010181 FMN binding GO:0016021 integral component of membrane KOG1607 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.46830 BP_3 97.30 12.73 660 642913091 XP_008201388.1 456 5.7e-43 PREDICTED: disks large 1 tumor suppressor protein isoform X10 [Tribolium castaneum] 642913090 XM_008203166.1 194 4.1107e-95 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X11, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 309 2.6e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.46832 BP_3 7.13 0.39 1184 91082269 XP_973494.1 428 1.8e-39 PREDICTED: eukaryotic translation initiation factor 4E-1A [Tribolium castaneum]>gi|270008177|gb|EFA04625.1| eukaryotic initiation factor 4E [Tribolium castaneum] -- -- -- -- -- K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 Q9DFS6 342 7.0e-31 Eukaryotic translation initiation factor 4E-1A OS=Danio rerio GN=eif4e1a PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.46833 BP_3 289.90 2.46 5980 642911486 XP_008199444.1 557 1.0e-53 PREDICTED: Na(+)/H(+) exchange regulatory cofactor NHE-RF2 [Tribolium castaneum]>gi|270014790|gb|EFA11238.1| hypothetical protein TcasGA2_TC010770 [Tribolium castaneum] -- -- -- -- -- K13358 SLC9A3R2, NHERF2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 http://www.genome.jp/dbget-bin/www_bget?ko:K13358 Q5ZM14 257 2.5e-20 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Gallus gallus GN=SLC9A3R1 PE=2 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.46834 BP_3 48.81 0.81 3197 642929628 XP_008195910.1 593 3.6e-58 PREDICTED: integrin alpha-X-like [Tribolium castaneum] -- -- -- -- -- K06585 ITGA9 integrin alpha 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06585 P13612 380 7.4e-35 Integrin alpha-4 OS=Homo sapiens GN=ITGA4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46836 BP_3 506.44 24.93 1271 91087219 XP_975481.1 675 4.4e-68 PREDICTED: pinin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H307 323 1.2e-28 Pinin OS=Homo sapiens GN=PNN PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46839 BP_3 411.45 3.11 6671 270006862 EFA03310.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013252 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q96IG2 1483 1.9e-162 F-box/LRR-repeat protein 20 OS=Homo sapiens GN=FBXL20 PE=1 SV=2 PF15966//PF00560//PF00646//PF12937//PF02126//PF13516//PF00152//PF13855 F-box//Leucine Rich Repeat//F-box domain//F-box-like//Phosphotriesterase family//Leucine Rich repeat//tRNA synthetases class II (D, K and N)//Leucine rich repeat GO:0006418//GO:0009056 tRNA aminoacylation for protein translation//catabolic process GO:0005524//GO:0008270//GO:0000166//GO:0005515//GO:0004812 ATP binding//zinc ion binding//nucleotide binding//protein binding//aminoacyl-tRNA ligase activity -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.46841 BP_3 49.66 0.33 7519 642924396 XP_008194278.1 1678 1.3e-183 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] 462327956 APGK01040876.1 174 6.44005e-83 Dendroctonus ponderosae Seq01040886, whole genome shotgun sequence K02178 BUB1 checkpoint serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02178 O43683 451 1.0e-42 Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens GN=BUB1 PE=1 SV=1 PF07714//PF04111//PF08656//PF00541//PF00069//PF00684//PF00170//PF03852//PF00227//PF06957//PF01025//PF07716//PF17060//PF04977//PF05478//PF00130//PF01920//PF03938//PF04728//PF07926//PF04513//PF02601//PF00416 Protein tyrosine kinase//Autophagy protein Apg6//DASH complex subunit Dad3//Adenoviral fibre protein (knob domain)//Protein kinase domain//DnaJ central domain//bZIP transcription factor//DNA mismatch endonuclease Vsr//Proteasome subunit//Coatomer (COPI) alpha subunit C-terminus//GrpE//Basic region leucine zipper//Monopolar spindle protein 2//Septum formation initiator//Prominin//Phorbol esters/diacylglycerol binding domain (C1 domain)//Prefoldin subunit//Outer membrane protein (OmpH-like)//Lipoprotein leucine-zipper//TPR/MLP1/MLP2-like protein//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//Ribosomal protein S13/S18 GO:0035556//GO:0042254//GO:0008608//GO:0006606//GO:0051603//GO:0030474//GO:0006298//GO:0007049//GO:0006355//GO:0006886//GO:0016192//GO:0006468//GO:0006914//GO:0006308//GO:0071988//GO:0006412//GO:0006457//GO:0019062 intracellular signal transduction//ribosome biogenesis//attachment of spindle microtubules to kinetochore//protein import into nucleus//proteolysis involved in cellular protein catabolic process//spindle pole body duplication//mismatch repair//cell cycle//regulation of transcription, DNA-templated//intracellular protein transport//vesicle-mediated transport//protein phosphorylation//autophagy//DNA catabolic process//protein localization to spindle pole body//translation//protein folding//virion attachment to host cell GO:0003700//GO:0003735//GO:0051082//GO:0051087//GO:0005524//GO:0004672//GO:0004519//GO:0000774//GO:0043565//GO:0005198//GO:0004298//GO:0042803//GO:0005515//GO:0008855//GO:0003723//GO:0031072 transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome//unfolded protein binding//chaperone binding//ATP binding//protein kinase activity//endonuclease activity//adenyl-nucleotide exchange factor activity//sequence-specific DNA binding//structural molecule activity//threonine-type endopeptidase activity//protein homodimerization activity//protein binding//exodeoxyribonuclease VII activity//RNA binding//heat shock protein binding GO:0016272//GO:0030126//GO:0009318//GO:0019028//GO:0005667//GO:0072686//GO:0005839//GO:0005622//GO:0005840//GO:0042729//GO:0016021//GO:0019031//GO:0019867 prefoldin complex//COPI vesicle coat//exodeoxyribonuclease VII complex//viral capsid//transcription factor complex//mitotic spindle//proteasome core complex//intracellular//ribosome//DASH complex//integral component of membrane//viral envelope//outer membrane KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.46844 BP_3 26.64 1.73 1033 91078348 XP_973652.1 149 3.5e-07 PREDICTED: prostaglandin E synthase 2 [Tribolium castaneum]>gi|270003893|gb|EFA00341.1| hypothetical protein TcasGA2_TC003180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- -- -- Cluster-8309.46845 BP_3 24.04 0.39 3254 478257801 ENN77944.1 1549 5.1e-169 hypothetical protein YQE_05621, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W3J8 748 1.6e-77 Dynein regulatory complex protein 1 homolog OS=Drosophila melanogaster GN=CG10958 PE=2 SV=1 PF04513//PF02742//PF02472//PF01972 Baculovirus polyhedron envelope protein, PEP, C terminus//Iron dependent repressor, metal binding and dimerisation domain//Biopolymer transport protein ExbD/TolR//Serine dehydrogenase proteinase GO:0006810 transport GO:0046914//GO:0046983//GO:0005215//GO:0005198 transition metal ion binding//protein dimerization activity//transporter activity//structural molecule activity GO:0016020//GO:0019028//GO:0016021//GO:0019031 membrane//viral capsid//integral component of membrane//viral envelope -- -- Cluster-8309.46846 BP_3 198.46 3.94 2719 642935358 XP_008197980.1 1191 1.4e-127 PREDICTED: uncharacterized protein LOC657906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46847 BP_3 108.78 1.99 2920 546681542 ERL91613.1 854 1.8e-88 hypothetical protein D910_08943, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46848 BP_3 198.73 5.40 2066 91086285 XP_967226.1 1600 4.0e-175 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] 827562488 XM_012696459.1 44 3.23188e-11 PREDICTED: Bombyx mori 4-coumarate--CoA ligase 1-like (LOC101735849), mRNA -- -- -- -- Q27757 1167 2.6e-126 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.46849 BP_3 2.00 0.40 532 -- -- -- -- -- 768311754 CP010982.1 520 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- PF03301//PF04931 Tryptophan 2,3-dioxygenase//DNA polymerase phi GO:0006260//GO:0006568//GO:0006351//GO:0019441 DNA replication//tryptophan metabolic process//transcription, DNA-templated//tryptophan catabolic process to kynurenine GO:0020037//GO:0003677//GO:0003887//GO:0004833 heme binding//DNA binding//DNA-directed DNA polymerase activity//tryptophan 2,3-dioxygenase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.46852 BP_3 19.05 0.47 2247 642934778 XP_008197804.1 2992 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein flightless-1 [Tribolium castaneum] 158287295 XM_309356.4 147 1.94602e-68 Anopheles gambiae str. PEST AGAP011292-PA (AgaP_AGAP011292) mRNA, complete cds -- -- -- -- Q24020 2297 2.7e-257 Protein flightless-1 OS=Drosophila melanogaster GN=fliI PE=2 SV=1 PF13855//PF14895//PF00560 Leucine rich repeat//Protein phosphatase 1 inhibitor//Leucine Rich Repeat GO:0010923 negative regulation of phosphatase activity GO:0005515//GO:0019902 protein binding//phosphatase binding -- -- KOG0444 Cytoskeletal regulator Flightless-I (contains leucine-rich and gelsolin repeats) Cluster-8309.46854 BP_3 63.23 0.68 4747 646710672 KDR16118.1 400 1.3e-35 hypothetical protein L798_10008 [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 383 4.9e-35 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13465//PF13912//PF16622//PF01113//PF00096//PF03015//PF00044//PF08533//PF07776 Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type//Dihydrodipicolinate reductase, N-terminus//Zinc finger, C2H2 type//Male sterility protein//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Beta-galactosidase C-terminal domain//Zinc-finger associated domain (zf-AD) GO:0046486//GO:0006687//GO:0055114//GO:0006027//GO:0009085//GO:0006012//GO:0009089 glycerolipid metabolic process//glycosphingolipid metabolic process//oxidation-reduction process//glycosaminoglycan catabolic process//lysine biosynthetic process//galactose metabolic process//lysine biosynthetic process via diaminopimelate GO:0016620//GO:0046872//GO:0080019//GO:0008270//GO:0004565//GO:0008839 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//metal ion binding//fatty-acyl-CoA reductase (alcohol-forming) activity//zinc ion binding//beta-galactosidase activity//4-hydroxy-tetrahydrodipicolinate reductase GO:0009341//GO:0005634 beta-galactosidase complex//nucleus -- -- Cluster-8309.46856 BP_3 613.61 5.92 5286 642928433 XP_008193783.1 6152 0.0e+00 PREDICTED: proteasome activator complex subunit 4 [Tribolium castaneum]>gi|270010813|gb|EFA07261.1| hypothetical protein TcasGA2_TC013292 [Tribolium castaneum] -- -- -- -- -- K06699 PSME4 proteasome activator subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06699 Q6NRP2 2946 0.0e+00 Proteasome activator complex subunit 4 OS=Xenopus laevis GN=psme4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1851 Uncharacterized conserved protein Cluster-8309.46857 BP_3 1245.78 15.30 4216 546683122 ERL92973.1 2083 7.9e-231 hypothetical protein D910_10276 [Dendroctonus ponderosae] 237874246 NM_001160401.1 165 3.62457e-78 Acyrthosiphon pisum aspartyl-tRNA synthetase (Aats-asp), mRNA K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 P14868 1669 3.3e-184 Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens GN=DARS PE=1 SV=2 PF00152//PF11538//PF01409 tRNA synthetases class II (D, K and N)//Snurportin1//tRNA synthetases class II core domain (F) GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0000166//GO:0004812//GO:0005524//GO:0000049//GO:0005515 nucleotide binding//aminoacyl-tRNA ligase activity//ATP binding//tRNA binding//protein binding GO:0005737 cytoplasm KOG0556 Aspartyl-tRNA synthetase Cluster-8309.4686 BP_3 3.00 1.14 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46862 BP_3 175.50 1.37 6479 642914773 XP_008190345.1 1450 3.1e-157 PREDICTED: protein SERAC1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SNQ7 389 1.4e-35 Protein SERAC1 OS=Danio rerio GN=serac1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46865 BP_3 671.00 18.67 2024 91081605 XP_975406.1 2055 6.7e-228 PREDICTED: conserved oligomeric Golgi complex subunit 8 [Tribolium castaneum]>gi|270006211|gb|EFA02659.1| hypothetical protein TcasGA2_TC008380 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKH0 1330 3.2e-145 Conserved oligomeric Golgi complex subunit 8 OS=Drosophila melanogaster GN=CG6488 PE=2 SV=1 PF04124//PF06248 Dor1-like family//Centromere/kinetochore Zw10 GO:0007067 mitotic nuclear division -- -- GO:0017119//GO:0000775//GO:0005634 Golgi transport complex//chromosome, centromeric region//nucleus KOG2069 Golgi transport complex subunit Cluster-8309.46866 BP_3 991.18 9.35 5401 91086067 XP_974022.1 2937 0.0e+00 PREDICTED: snake venom 5'-nucleotidase isoform X1 [Tribolium castaneum]>gi|270009911|gb|EFA06359.1| hypothetical protein TcasGA2_TC009234 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 O34313 387 1.9e-35 Trifunctional nucleotide phosphoesterase protein YfkN OS=Bacillus subtilis (strain 168) GN=yfkN PE=1 SV=1 PF02872//PF00149 5'-nucleotidase, C-terminal domain//Calcineurin-like phosphoesterase GO:0009166 nucleotide catabolic process GO:0016787 hydrolase activity -- -- KOG4697 Integral membrane protein involved in transport between the late Golgi and endosome Cluster-8309.46867 BP_3 190.99 1.82 5349 817193091 XP_012271999.1 427 1.1e-38 PREDICTED: actin-binding protein anillin-like isoform X1 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q9NQW6 263 4.6e-21 Actin-binding protein anillin OS=Homo sapiens GN=ANLN PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46869 BP_3 3.00 1.36 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46871 BP_3 1704.00 21.27 4153 765150019 XP_011485511.1 184 1.2e-10 PREDICTED: ring-infected erythrocyte surface antigen-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04947 Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.46872 BP_3 288.99 1.67 8627 546674242 ERL85667.1 1272 1.8e-136 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q9VHN9 460 1.1e-43 Hermansky-Pudlak syndrome 5 protein homolog OS=Drosophila melanogaster GN=p PE=2 SV=1 PF13639//PF12678 Ring finger domain//RING-H2 zinc finger -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.46873 BP_3 239.42 1.38 8628 546674242 ERL85667.1 1224 6.6e-131 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q9VHN9 464 3.6e-44 Hermansky-Pudlak syndrome 5 protein homolog OS=Drosophila melanogaster GN=p PE=2 SV=1 PF12678//PF13639 RING-H2 zinc finger//Ring finger domain -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.46875 BP_3 30.65 0.87 1992 478251087 ENN71563.1 634 3.9e-63 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 1.5e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF07685//PF08465 CobB/CobQ-like glutamine amidotransferase domain//Thymidine kinase from Herpesvirus C-terminal GO:0009236//GO:0006206//GO:0006230 cobalamin biosynthetic process//pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0003824//GO:0005524//GO:0004797 catalytic activity//ATP binding//thymidine kinase activity -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.46876 BP_3 571.00 16.47 1963 332373082 AEE61682.1 583 3.2e-57 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05B54 156 4.3e-09 Transmembrane protein 134 OS=Bos taurus GN=TMEM134 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46878 BP_3 177.80 1.01 8807 478258750 ENN78776.1 2014 1.7e-222 hypothetical protein YQE_04763, partial [Dendroctonus ponderosae] 780682419 XM_011699543.1 39 8.39377e-08 PREDICTED: Wasmannia auropunctata anoctamin-1 (LOC105455869), transcript variant X4, mRNA K19480 ANO5, GDD1, TMEM16E anoctamin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K19480 Q75V66 924 1.7e-97 Anoctamin-5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 PF13939//PF16178//PF01091 Toxin TisB, type I toxin-antitoxin system//Dimerisation domain of Ca+-activated chloride-channel, anoctamin//PTN/MK heparin-binding protein family, C-terminal domain GO:0040007//GO:0007165//GO:0008283//GO:0009432//GO:0022611//GO:0006820 growth//signal transduction//cell proliferation//SOS response//dormancy process//anion transport GO:0008083//GO:0046983//GO:0005253 growth factor activity//protein dimerization activity//anion channel activity GO:0005887 integral component of plasma membrane KOG2514 Uncharacterized conserved protein Cluster-8309.46879 BP_3 64.09 0.36 8862 780669493 XP_011694869.1 1341 1.8e-144 PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata]>gi|780669497|ref|XP_011694870.1| PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata]>gi|780669501|ref|XP_011694871.1| PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata] 642922119 XM_008194802.1 71 1.37395e-25 PREDICTED: Tribolium castaneum uncharacterized LOC103312925 (LOC103312925), mRNA -- -- -- -- M9NEY8 1073 9.0e-115 DNA N6-methyl adenine demethylase OS=Drosophila melanogaster GN=Tet PE=1 SV=1 PF07646 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46880 BP_3 11.28 0.41 1616 642918472 XP_971273.2 211 3.6e-14 PREDICTED: protein NDRG3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08653 DASH complex subunit Dam1 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.46881 BP_3 34.41 1.00 1957 478259228 ENN79130.1 801 1.7e-82 hypothetical protein YQE_04317, partial [Dendroctonus ponderosae] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 O34940 288 2.1e-24 Putative sugar lactone lactonase YvrE OS=Bacillus subtilis (strain 168) GN=yvrE PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46882 BP_3 119.14 1.38 4458 91082383 XP_968748.1 1170 6.2e-125 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 791 2.3e-82 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00005//PF03266//PF03193//PF02367//PF00931//PF00664//PF13304//PF01926//PF00437//PF00004 ABC transporter//NTPase//Protein of unknown function, DUF258//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0055085//GO:0006810//GO:0002949 transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0098519//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0042626//GO:0017111 ATP binding//nucleotide phosphatase activity, acting on free nucleotides//ADP binding//GTPase activity//GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//nucleoside-triphosphatase activity GO:0016021 integral component of membrane -- -- Cluster-8309.46884 BP_3 121.87 1.57 4030 546684171 ERL93876.1 1173 2.5e-125 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P57775 470 3.4e-45 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF15966//PF00400//PF00646//PF01442//PF12937//PF03357 F-box//WD domain, G-beta repeat//F-box domain//Apolipoprotein A1/A4/E domain//F-box-like//Snf7 GO:0007034//GO:0006869//GO:0042157 vacuolar transport//lipid transport//lipoprotein metabolic process GO:0005515//GO:0008289 protein binding//lipid binding GO:0005576 extracellular region KOG2911 Uncharacterized conserved protein Cluster-8309.46886 BP_3 96.23 3.10 1787 817088843 XP_012267256.1 438 1.9e-40 PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae]>gi|817088845|ref|XP_012267257.1| PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae] -- -- -- -- -- K03004 RPA43 DNA-directed RNA polymerase I subunit RPA43 http://www.genome.jp/dbget-bin/www_bget?ko:K03004 Q3B726 275 6.2e-23 DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens GN=TWISTNB PE=1 SV=1 PF03876 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG4134 DNA-dependent RNA polymerase I Cluster-8309.46887 BP_3 103.99 1.83 3033 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46888 BP_3 345.65 4.80 3761 642926192 XP_008194823.1 1297 9.8e-140 PREDICTED: glycylpeptide N-tetradecanoyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K00671 E2.3.1.97, NMT glycylpeptide N-tetradecanoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00671 P30419 1044 8.8e-112 Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens GN=NMT1 PE=1 SV=2 PF01233//PF07402//PF13508//PF02799 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//Human herpesvirus U26 protein//Acetyltransferase (GNAT) domain//Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0004379 N-acetyltransferase activity//glycylpeptide N-tetradecanoyltransferase activity GO:0016021 integral component of membrane KOG2779 N-myristoyl transferase Cluster-8309.46889 BP_3 1381.69 28.42 2635 642926192 XP_008194823.1 1891 9.1e-209 PREDICTED: glycylpeptide N-tetradecanoyltransferase 2 [Tribolium castaneum] 670428483 XM_008656828.1 53 4.10815e-16 PREDICTED: Zea mays glycylpeptide N-tetradecanoyltransferase 1 (LOC100283890), transcript variant X2, mRNA K00671 E2.3.1.97, NMT glycylpeptide N-tetradecanoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00671 P30419 1554 4.5e-171 Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens GN=NMT1 PE=1 SV=2 PF02799//PF13508//PF07402//PF01233 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain//Acetyltransferase (GNAT) domain//Human herpesvirus U26 protein//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0004379//GO:0008080 glycylpeptide N-tetradecanoyltransferase activity//N-acetyltransferase activity GO:0016021 integral component of membrane KOG2779 N-myristoyl transferase Cluster-8309.4689 BP_3 12.00 0.37 1870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46892 BP_3 114.00 5.05 1380 768443194 XP_011563401.1 213 1.8e-14 PREDICTED: homeobox protein 6-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588 C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.46895 BP_3 41.06 0.61 3545 642922624 XP_008193254.1 3526 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46896 BP_3 37.71 0.64 3115 91092214 XP_969938.1 2127 4.6e-236 PREDICTED: uncharacterized protein LOC658457 [Tribolium castaneum]>gi|270014434|gb|EFA10882.1| hypothetical protein TcasGA2_TC001706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48613 198 9.1e-14 Protein tipE OS=Drosophila melanogaster GN=tipE PE=2 SV=1 PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.46898 BP_3 1365.17 13.90 5027 642927882 XP_008195435.1 2852 0.0e+00 PREDICTED: zinc finger protein 609-like isoform X2 [Tribolium castaneum] 642927883 XM_008197214.1 252 1.87601e-126 PREDICTED: Tribolium castaneum zinc finger protein 608-like (LOC662416), transcript variant X3, mRNA -- -- -- -- Q56A10 383 5.2e-35 Zinc finger protein 608 OS=Mus musculus GN=Znf608 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46903 BP_3 454.98 3.85 5988 91080961 XP_974748.1 580 2.2e-56 PREDICTED: ubiquitin-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z2M6 446 3.1e-42 Ubiquitin-like protein 3 OS=Mus musculus GN=Ubl3 PE=1 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46904 BP_3 1135.78 9.44 6092 91080961 XP_974748.1 580 2.2e-56 PREDICTED: ubiquitin-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z2M6 446 3.1e-42 Ubiquitin-like protein 3 OS=Mus musculus GN=Ubl3 PE=1 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46908 BP_3 233.87 3.15 3867 91087699 XP_974256.1 950 1.7e-99 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 518 8.9e-51 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF01036//PF00852 Bacteriorhodopsin-like protein//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0070085//GO:0006486 glycosylation//protein glycosylation GO:0008417//GO:0016757 fucosyltransferase activity//transferase activity, transferring glycosyl groups GO:0005794//GO:0016020 Golgi apparatus//membrane KOG2619 Fucosyltransferase Cluster-8309.46909 BP_3 1391.29 6.18 11144 642910592 XP_008200017.1 3242 0.0e+00 PREDICTED: uncharacterized protein LOC103314818 isoform X2 [Tribolium castaneum] 642910591 XM_008201795.1 107 1.68098e-45 PREDICTED: Tribolium castaneum uncharacterized LOC103314818 (LOC103314818), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07359//PF08272 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)//Topoisomerase I zinc-ribbon-like GO:0006265//GO:0042742 DNA topological change//defense response to bacterium GO:0003677//GO:0003918 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005694 chromosome -- -- Cluster-8309.46911 BP_3 13.71 1.31 797 270016897 EFA13343.1 199 4.3e-13 hypothetical protein TcasGA2_TC005298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46912 BP_3 2.00 0.40 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46913 BP_3 50.00 1.00 2698 646705478 KDR13176.1 151 5.4e-07 hypothetical protein L798_12933, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03852//PF05653 DNA mismatch endonuclease Vsr//Magnesium transporter NIPA GO:0006298//GO:0015693 mismatch repair//magnesium ion transport GO:0004519//GO:0015095 endonuclease activity//magnesium ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.46914 BP_3 90.01 1.69 2864 478256087 ENN76286.1 2307 5.7e-257 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 1467 6.0e-161 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF00733//PF00764//PF02568 Asparagine synthase//Arginosuccinate synthase//Thiamine biosynthesis protein (ThiI) GO:0006522//GO:0008033//GO:0006526//GO:0006529//GO:0006531//GO:0006560 alanine metabolic process//tRNA processing//arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process GO:0004066//GO:0004810//GO:0005524//GO:0004055 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity//ATP binding//argininosuccinate synthase activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.46915 BP_3 113.34 2.55 2438 478256087 ENN76286.1 1327 2.1e-143 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 923 6.1e-98 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF00764//PF02568//PF00733 Arginosuccinate synthase//Thiamine biosynthesis protein (ThiI)//Asparagine synthase GO:0006526//GO:0006529//GO:0006531//GO:0006560//GO:0006522//GO:0008033 arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process//alanine metabolic process//tRNA processing GO:0004810//GO:0005524//GO:0004055//GO:0004066 tRNA adenylyltransferase activity//ATP binding//argininosuccinate synthase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.46916 BP_3 18.37 0.43 2333 270001539 EEZ97986.1 1123 9.1e-120 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 141 4.37616e-65 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 526 6.3e-52 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF00076//PF16367//PF01174//PF03153 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//SNO glutamine amidotransferase family//Transcription factor IIA, alpha/beta subunit GO:0042819//GO:0006541//GO:0006367//GO:0042823 vitamin B6 biosynthetic process//glutamine metabolic process//transcription initiation from RNA polymerase II promoter//pyridoxal phosphate biosynthetic process GO:0004359//GO:0003676 glutaminase activity//nucleic acid binding GO:0005672 transcription factor TFIIA complex KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.46921 BP_3 7.87 0.34 1392 189235434 XP_001813433.1 1265 1.9e-136 PREDICTED: paraplegin [Tribolium castaneum]>gi|270004289|gb|EFA00737.1| hypothetical protein TcasGA2_TC003619 [Tribolium castaneum] 242019804 XM_002430304.1 38 4.6742e-08 Pediculus humanus corporis conserved hypothetical protein, mRNA K09552 SPG7 spastic paraplegia 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09552 Q9UQ90 880 3.4e-93 Paraplegin OS=Homo sapiens GN=SPG7 PE=1 SV=2 PF01434//PF00004//PF07724 Peptidase family M41//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily) GO:0030163//GO:0006508 protein catabolic process//proteolysis GO:0017111//GO:0004222//GO:0008270//GO:0005524 nucleoside-triphosphatase activity//metalloendopeptidase activity//zinc ion binding//ATP binding GO:0016021 integral component of membrane KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.46922 BP_3 620.28 9.20 3540 91087023 XP_974255.1 1314 9.9e-142 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q9C0D9 721 2.4e-74 Ethanolaminephosphotransferase 1 OS=Homo sapiens GN=EPT1 PE=1 SV=3 PF13292 1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694 terpenoid biosynthetic process//steroid biosynthetic process GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.46923 BP_3 3.00 1.22 409 478250268 ENN70767.1 301 3.3e-25 hypothetical protein YQE_12527, partial [Dendroctonus ponderosae] -- -- -- -- -- K09751 TMPRSS11B transmembrane protease, serine 11B http://www.genome.jp/dbget-bin/www_bget?ko:K09751 P05049 176 4.3e-12 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.46924 BP_3 12.22 1.27 757 242008321 XP_002424955.1 192 2.7e-12 conserved hypothetical protein [Pediculus humanus corporis]>gi|212508569|gb|EEB12217.1| conserved hypothetical protein [Pediculus humanus corporis] 642915784 XM_963085.2 121 1.80699e-54 PREDICTED: Tribolium castaneum cofilin/actin-depolymerizing factor homolog (LOC656560), mRNA K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 186 5.5e-13 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular -- -- Cluster-8309.46925 BP_3 31.16 2.02 1036 815803125 XP_012222257.1 355 4.6e-31 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2-like isoform X1 [Linepithema humile] 195391703 XM_002054464.1 69 2.01988e-25 Drosophila virilis GJ22773 (Dvir\GJ22773), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q9Z2Z9 277 2.1e-23 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Mus musculus GN=Gfpt2 PE=2 SV=3 PF01380//PF13397 SIS domain//RNA polymerase-binding protein GO:0005975//GO:0045893 carbohydrate metabolic process//positive regulation of transcription, DNA-templated GO:0001000//GO:0030246 bacterial-type RNA polymerase core enzyme binding//carbohydrate binding -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.46926 BP_3 63.16 0.41 7699 642939018 XP_008198083.1 860 9.5e-89 PREDICTED: protein SCAF8 isoform X2 [Tribolium castaneum] 195123078 XM_002006001.1 64 9.28702e-22 Drosophila mojavensis GI18767 (Dmoj\GI18767), mRNA K13191 RBM16, SCAF8 RNA-binding protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13191 Q6DID3 568 2.8e-56 Protein SCAF8 OS=Mus musculus GN=Scaf8 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0132 RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains Cluster-8309.46928 BP_3 1256.86 12.35 5197 478255927 ENN76129.1 1966 3.6e-217 hypothetical protein YQE_07349, partial [Dendroctonus ponderosae]>gi|546676523|gb|ERL87517.1| hypothetical protein D910_04909 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NRA2 315 4.1e-27 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF00379//PF07690 Insect cuticle protein//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.46929 BP_3 625.96 4.87 6482 642931680 XP_008196686.1 193 1.8e-11 PREDICTED: neurofilament heavy polypeptide-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46930 BP_3 1.01 0.52 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46931 BP_3 10.00 1.59 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF04218 helix-turn-helix, Psq domain//CENP-B N-terminal DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.46932 BP_3 1868.00 16.60 5715 546677666 ERL88460.1 5013 0.0e+00 hypothetical protein D910_05846 [Dendroctonus ponderosae] -- -- -- -- -- K07207 TSC2 tuberous sclerosis 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07207 P49815 1939 2.2e-215 Tuberin OS=Homo sapiens GN=TSC2 PE=1 SV=2 PF02888//PF04088//PF02145//PF03542 Calmodulin binding domain//Peroxin 13, N-terminal region//Rap/ran-GAP//Tuberin GO:0043547//GO:0006813//GO:0051056//GO:0016560 positive regulation of GTPase activity//potassium ion transport//regulation of small GTPase mediated signal transduction//protein import into peroxisome matrix, docking GO:0005516//GO:0005096//GO:0015269 calmodulin binding//GTPase activator activity//calcium-activated potassium channel activity GO:0016021//GO:0005777 integral component of membrane//peroxisome KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46938 BP_3 53.32 0.33 7981 642924396 XP_008194278.1 1678 1.4e-183 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] 706147644 XM_010207329.1 63 3.46314e-21 PREDICTED: Colius striatus family with sequence similarity 76, member B (FAM76B), partial mRNA -- -- -- -- Q5ZJ65 678 5.1e-69 Protein FAM76A OS=Gallus gallus GN=FAM76A PE=2 SV=1 PF00227//PF03852//PF00170//PF00541//PF00069//PF08656//PF04111//PF07714//PF17060//PF01025//PF07716//PF01920//PF05478//PF04977//PF00416//PF02601//PF04513//PF07926//PF04728//PF03938 Proteasome subunit//DNA mismatch endonuclease Vsr//bZIP transcription factor//Adenoviral fibre protein (knob domain)//Protein kinase domain//DASH complex subunit Dad3//Autophagy protein Apg6//Protein tyrosine kinase//Monopolar spindle protein 2//GrpE//Basic region leucine zipper//Prefoldin subunit//Prominin//Septum formation initiator//Ribosomal protein S13/S18//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//TPR/MLP1/MLP2-like protein//Lipoprotein leucine-zipper//Outer membrane protein (OmpH-like) GO:0006298//GO:0030474//GO:0051603//GO:0008608//GO:0006606//GO:0042254//GO:0019062//GO:0006457//GO:0006412//GO:0071988//GO:0006308//GO:0006914//GO:0006468//GO:0006355//GO:0007049 mismatch repair//spindle pole body duplication//proteolysis involved in cellular protein catabolic process//attachment of spindle microtubules to kinetochore//protein import into nucleus//ribosome biogenesis//virion attachment to host cell//protein folding//translation//protein localization to spindle pole body//DNA catabolic process//autophagy//protein phosphorylation//regulation of transcription, DNA-templated//cell cycle GO:0004519//GO:0004672//GO:0005524//GO:0003735//GO:0051087//GO:0051082//GO:0003700//GO:0003723//GO:0008855//GO:0042803//GO:0004298//GO:0005198//GO:0043565//GO:0000774 endonuclease activity//protein kinase activity//ATP binding//structural constituent of ribosome//chaperone binding//unfolded protein binding//transcription factor activity, sequence-specific DNA binding//RNA binding//exodeoxyribonuclease VII activity//protein homodimerization activity//threonine-type endopeptidase activity//structural molecule activity//sequence-specific DNA binding//adenyl-nucleotide exchange factor activity GO:0072686//GO:0005667//GO:0019028//GO:0009318//GO:0016272//GO:0019867//GO:0019031//GO:0016021//GO:0042729//GO:0005840//GO:0005839//GO:0005622 mitotic spindle//transcription factor complex//viral capsid//exodeoxyribonuclease VII complex//prefoldin complex//outer membrane//viral envelope//integral component of membrane//DASH complex//ribosome//proteasome core complex//intracellular KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.46940 BP_3 25.00 0.63 2214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46941 BP_3 55.00 1.65 1900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46950 BP_3 1.00 19.14 227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46951 BP_3 9.00 2.08 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46952 BP_3 629.56 4.95 6428 642929205 XP_008195735.1 3696 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 560 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q9Y4E6 1822 9.2e-202 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF07569//PF01506//PF00784//PF00400 TUP1-like enhancer of split//Hepatitis C virus non-structural 5a protein membrane anchor//MyTH4 domain//WD domain, G-beta repeat GO:0006144//GO:0006355//GO:0006508 purine nucleobase metabolic process//regulation of transcription, DNA-templated//proteolysis GO:0005515//GO:0004197//GO:0017111//GO:0004252//GO:0003968 protein binding//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0005634//GO:0005856//GO:0031379 nucleus//cytoskeleton//RNA-directed RNA polymerase complex KOG4155 FOG: WD40 repeat Cluster-8309.46953 BP_3 46.11 0.34 6740 642912146 XP_008200825.1 1113 3.8e-118 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNM6 504 6.5e-49 Protein FAM102A OS=Xenopus laevis GN=fam102a PE=2 SV=1 PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.46954 BP_3 1133.78 29.55 2141 189238236 XP_972123.2 372 1.0e-32 PREDICTED: guanine nucleotide-binding protein subunit gamma-e [Tribolium castaneum]>gi|270008671|gb|EFA05119.1| hypothetical protein TcasGA2_TC015232 [Tribolium castaneum] 743280388 KM065747.1 140 1.44244e-64 Culex quinquefasciatus clone C2B G-protein gamma-subunit mRNA, complete cds K04547 GNG13 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 http://www.genome.jp/dbget-bin/www_bget?ko:K04547 Q9NFZ3 335 8.2e-30 Guanine nucleotide-binding protein subunit gamma-e OS=Drosophila melanogaster GN=Ggamma30A PE=1 SV=1 PF00631//PF02501 GGL domain//Type II secretion system (T2SS), protein I GO:0007165//GO:0015031//GO:0015628//GO:0007186 signal transduction//protein transport//protein secretion by the type II secretion system//G-protein coupled receptor signaling pathway GO:0008565//GO:0004871 protein transporter activity//signal transducer activity GO:0005834//GO:0015627 heterotrimeric G-protein complex//type II protein secretion system complex KOG4119 G protein gamma subunit Cluster-8309.46956 BP_3 1142.73 42.33 1593 478250645 ENN71137.1 1207 1.1e-129 hypothetical protein YQE_12068, partial [Dendroctonus ponderosae] -- -- -- -- -- K17525 CHID1 chitinase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17525 A0JPQ9 801 5.6e-84 Chitinase domain-containing protein 1 OS=Rattus norvegicus GN=Chid1 PE=2 SV=2 PF00704//PF03644 Glycosyl hydrolases family 18//Glycosyl hydrolase family 85 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0033925 hydrolase activity, hydrolyzing O-glycosyl compounds//mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2091 Predicted member of glycosyl hydrolase family 18 Cluster-8309.46958 BP_3 127.05 1.37 4770 478255990 ENN76189.1 1139 2.6e-121 hypothetical protein YQE_07157, partial [Dendroctonus ponderosae] 755992161 XM_011314822.1 134 7.01638e-61 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 710 6.0e-73 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00583//PF00549 Acetyltransferase (GNAT) family//CoA-ligase GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0003824//GO:0008080 catalytic activity//N-acetyltransferase activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.46959 BP_3 167.79 2.33 3768 642915551 XP_008190663.1 1298 7.5e-140 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 71 5.81211e-26 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 3.0e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.46960 BP_3 340.23 4.14 4251 642926413 XP_008191952.1 2942 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X1 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.25991e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 3.2e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.46962 BP_3 510.92 5.11 5108 91087085 XP_974959.1 1184 1.7e-126 PREDICTED: phytepsin [Tribolium castaneum]>gi|270010541|gb|EFA06989.1| hypothetical protein TcasGA2_TC009950 [Tribolium castaneum] -- -- -- -- -- K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 593 2.4e-59 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF03145//PF01186//PF02176//PF00026 Seven in absentia protein family//Lysyl oxidase//TRAF-type zinc finger//Eukaryotic aspartyl protease GO:0055114//GO:0006508//GO:0006511//GO:0007275 oxidation-reduction process//proteolysis//ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0016641//GO:0004190//GO:0005507 zinc ion binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//aspartic-type endopeptidase activity//copper ion binding GO:0005634 nucleus KOG1339 Aspartyl protease Cluster-8309.46963 BP_3 183.41 3.73 2664 189236857 XP_974302.2 1925 1.1e-212 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum] 541975047 XM_005440594.1 35 4.21317e-06 PREDICTED: Falco cherrug solute carrier family 36 (proton/amino acid symporter), member 1 (SLC36A1), mRNA K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 842 1.6e-88 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.46964 BP_3 7.82 0.57 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46965 BP_3 107.50 1.45 3871 572098878 AHF48760.1 2078 2.8e-230 mitochondrial arginyl-tRNA synthetase [Caryedes brasiliensis] 874501526 XM_013108851.1 55 4.68283e-17 PREDICTED: Anas platyrhynchos mitochondrial ribosomal protein S9 (MRPS9), mRNA K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 Q0P5H7 921 1.7e-97 Probable arginine--tRNA ligase, mitochondrial OS=Bos taurus GN=RARS2 PE=2 SV=1 PF00750//PF00380//PF05746 tRNA synthetases class I (R)//Ribosomal protein S9/S16//DALR anticodon binding domain GO:0006525//GO:0006412//GO:0006560//GO:0006420//GO:0042254 arginine metabolic process//translation//proline metabolic process//arginyl-tRNA aminoacylation//ribosome biogenesis GO:0005524//GO:0004814//GO:0003735 ATP binding//arginine-tRNA ligase activity//structural constituent of ribosome GO:0005840 ribosome KOG1195 Arginyl-tRNA synthetase Cluster-8309.46966 BP_3 486.58 6.94 3673 642922521 XP_008193210.1 3245 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1353 1.3e-147 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF00514//PF02985 Armadillo/beta-catenin-like repeat//HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.46969 BP_3 9.56 0.85 831 642930331 XP_008196350.1 235 3.0e-17 PREDICTED: ataxin-10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5FVB0 125 7.1e-06 Ataxin-10 OS=Xenopus tropicalis GN=atxn10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46971 BP_3 526.00 4.52 5897 861624593 KMQ88311.1 3247 0.0e+00 hypothetical protein RF55_12227 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668//PF15220 Aspartyl protease//Hypoxia-inducible lipid droplet-associated GO:0001819//GO:0010884//GO:0006508//GO:0008284 positive regulation of cytokine production//positive regulation of lipid storage//proteolysis//positive regulation of cell proliferation GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.46972 BP_3 45.78 1.54 1728 332375352 AEE62817.1 223 1.6e-15 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46974 BP_3 62.96 2.38 1566 91079959 XP_969470.1 510 7.4e-49 PREDICTED: three-prime repair exonuclease 1 [Tribolium castaneum]>gi|270003252|gb|EEZ99699.1| hypothetical protein TcasGA2_TC002459 [Tribolium castaneum] -- -- -- -- -- K10791 TREX2 three prime repair exonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10791 Q9R1A9 252 2.5e-20 Three prime repair exonuclease 2 OS=Mus musculus GN=Trex2 PE=2 SV=1 PF13482//PF03104 RNase_H superfamily//DNA polymerase family B, exonuclease domain -- -- GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- -- -- Cluster-8309.46977 BP_3 253.40 5.67 2444 642935245 XP_008197928.1 1930 2.5e-213 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 311 1.44245e-159 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 828 6.4e-87 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF05790 Immunoglobulin domain//Immunoglobulin C2-set domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.4698 BP_3 4.00 0.39 789 449273738 EMC83152.1 226 3.2e-16 hypothetical protein A306_08766, partial [Columba livia] -- -- -- -- -- -- -- -- -- A9GP90 147 1.9e-08 Urease accessory protein UreG OS=Sorangium cellulosum (strain So ce56) GN=ureG PE=3 SV=1 PF03689 Nepovirus coat protein, N-terminal domain -- -- -- -- GO:0019028 viral capsid KOG2693 Putative zinc transporter Cluster-8309.46981 BP_3 464.87 4.99 4784 332372957 AEE61620.1 2271 1.4e-252 unknown [Dendroctonus ponderosae] 242003777 XM_002422811.1 148 1.16102e-68 Pediculus humanus corporis conserved hypothetical protein, mRNA K11142 LAP3 cytosol aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11142 P00727 1029 6.1e-110 Cytosol aminopeptidase OS=Bos taurus GN=LAP3 PE=1 SV=3 PF02789//PF04140//PF02544//PF00883 Cytosol aminopeptidase family, N-terminal domain//Isoprenylcysteine carboxyl methyltransferase (ICMT) family//3-oxo-5-alpha-steroid 4-dehydrogenase//Cytosol aminopeptidase family, catalytic domain GO:0006629//GO:0006481//GO:0006508//GO:0006479 lipid metabolic process//C-terminal protein methylation//proteolysis//protein methylation GO:0004177//GO:0004671//GO:0016627 aminopeptidase activity//protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005622//GO:0005737 integral component of membrane//intracellular//cytoplasm -- -- Cluster-8309.46983 BP_3 445.86 5.84 3971 642919697 XP_008192026.1 4505 0.0e+00 PREDICTED: putative ATP-dependent RNA helicase DHX57 [Tribolium castaneum]>gi|270005433|gb|EFA01881.1| hypothetical protein TcasGA2_TC007486 [Tribolium castaneum] -- -- -- -- -- K13026 DHX57 ATP-dependent RNA helicase DHX57 http://www.genome.jp/dbget-bin/www_bget?ko:K13026 Q6P158 2493 8.8e-280 Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens GN=DHX57 PE=1 SV=2 PF00270//PF00437//PF04408//PF00642//PF05773//PF00005 DEAD/DEAH box helicase//Type II/IV secretion system protein//Helicase associated domain (HA2)//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//RWD domain//ABC transporter GO:0006810 transport GO:0008270//GO:0016887//GO:0003676//GO:0046872//GO:0004386//GO:0005524//GO:0008026//GO:0005515 zinc ion binding//ATPase activity//nucleic acid binding//metal ion binding//helicase activity//ATP binding//ATP-dependent helicase activity//protein binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.46984 BP_3 36.01 0.45 4113 642923221 XP_008193661.1 1362 3.1e-147 PREDICTED: uncharacterized protein LOC103313092 [Tribolium castaneum] -- -- -- -- -- K18269 PDCD10 programmed cell death protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18269 Q6DF07 344 1.4e-30 Programmed cell death protein 10 OS=Xenopus tropicalis GN=pdcd10 PE=2 SV=1 PF09815//PF00863//PF04048 XK-related protein//Peptidase family C4//Sec8 exocyst complex component specific domain GO:0006904//GO:0015031//GO:0006508 vesicle docking involved in exocytosis//protein transport//proteolysis GO:0008234 cysteine-type peptidase activity GO:0016021//GO:0000145 integral component of membrane//exocyst KOG4025 Putative apoptosis related protein Cluster-8309.46986 BP_3 41.37 1.05 2199 642929609 XP_008195902.1 2244 8.9e-250 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] 642929608 XM_008197680.1 179 3.09682e-86 PREDICTED: Tribolium castaneum FAS-associated factor 1 (LOC664346), mRNA -- -- -- -- Q9UNN5 941 4.5e-100 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF00789//PF00240//PF00430//PF05279 UBX domain//Ubiquitin family//ATP synthase B/B' CF(0)//Aspartyl beta-hydroxylase N-terminal region GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078//GO:0005515 hydrogen ion transmembrane transporter activity//protein binding GO:0045263//GO:0016020 proton-transporting ATP synthase complex, coupling factor F(o)//membrane KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.46988 BP_3 78.26 2.83 1624 270001943 EEZ98390.1 619 1.8e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 6.05971e-117 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 7.6e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.46989 BP_3 35.00 9.09 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46990 BP_3 55.00 15.18 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46991 BP_3 262.88 3.49 3923 642940154 XP_008194847.1 1161 6.0e-124 PREDICTED: myoneurin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 345 1.0e-30 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF02714//PF00651 Calcium-dependent channel, 7TM region, putative phosphate//BTB/POZ domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.46992 BP_3 237.53 4.17 3036 642940156 XP_008194851.1 1063 1.1e-112 PREDICTED: myoneurin-like isoform X3 [Tribolium castaneum]>gi|642940158|ref|XP_008194859.1| PREDICTED: myoneurin-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 335 1.2e-29 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF02714//PF00651//PF01527 Calcium-dependent channel, 7TM region, putative phosphate//BTB/POZ domain//Transposase GO:0006313 transposition, DNA-mediated GO:0004803//GO:0005515//GO:0003677 transposase activity//protein binding//DNA binding GO:0016020 membrane -- -- Cluster-8309.46993 BP_3 472.31 11.31 2304 189237223 XP_969624.2 1426 6.6e-155 PREDICTED: 45 kDa calcium-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKE5 310 7.0e-27 45 kDa calcium-binding protein OS=Gallus gallus GN=SDF4 PE=2 SV=2 PF12763//PF13202//PF13499//PF13833//PF00036//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG4251 Calcium binding protein Cluster-8309.46994 BP_3 150.54 6.21 1461 642912660 XP_008200953.1 1394 2.2e-151 PREDICTED: aldose reductase-like [Tribolium castaneum]>gi|270002625|gb|EEZ99072.1| hypothetical protein TcasGA2_TC004950 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 758 5.0e-79 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.46997 BP_3 72.92 0.72 5165 815810119 XP_012225949.1 195 8.2e-12 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q9V5M3 135 3.1e-06 Longitudinals lacking protein, isoforms N/O/W/X/Y OS=Drosophila melanogaster GN=lola PE=1 SV=3 PF13912//PF01363//PF02176//PF00096//PF04805//PF13465 C2H2-type zinc finger//FYVE zinc finger//TRAF-type zinc finger//Zinc finger, C2H2 type//E10-like protein conserved region//Zinc-finger double domain GO:0055114 oxidation-reduction process GO:0008270//GO:0046872//GO:0016972 zinc ion binding//metal ion binding//thiol oxidase activity -- -- -- -- Cluster-8309.47 BP_3 4.00 0.82 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47001 BP_3 686.69 6.09 5727 642929059 XP_008195674.1 2839 0.0e+00 PREDICTED: A-agglutinin anchorage subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9S0 859 3.8e-90 MTSS1-like protein OS=Mus musculus GN=Mtss1l PE=1 SV=1 PF14980//PF02205//PF08397 TIP39 peptide//WH2 motif//IRSp53/MIM homology domain GO:0007218//GO:0007009 neuropeptide signaling pathway//plasma membrane organization GO:0003779 actin binding GO:0005576 extracellular region -- -- Cluster-8309.47002 BP_3 823.67 8.50 4962 -- -- -- -- -- 642916579 XM_008193556.1 49 1.30202e-13 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein L (LOC657712), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47004 BP_3 2131.11 32.14 3488 270007542 EFA03990.1 2206 3.6e-245 hypothetical protein TcasGA2_TC014139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLB0 1005 2.7e-107 MAGUK p55 subfamily member 6 OS=Mus musculus GN=Mpp6 PE=1 SV=1 PF13180//PF03193//PF14604//PF00018//PF00595 PDZ domain//Protein of unknown function, DUF258//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005525//GO:0005515//GO:0003924 GTP binding//protein binding//GTPase activity -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.47005 BP_3 38.11 0.59 3416 270007542 EFA03990.1 2360 4.9e-263 hypothetical protein TcasGA2_TC014139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLB0 1099 3.3e-118 MAGUK p55 subfamily member 6 OS=Mus musculus GN=Mpp6 PE=1 SV=1 PF13180//PF14604//PF00018//PF00595//PF03193 PDZ domain//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF)//Protein of unknown function, DUF258 -- -- GO:0003924//GO:0005515//GO:0005525 GTPase activity//protein binding//GTP binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.47007 BP_3 94.69 0.49 9558 642934439 XP_008197663.1 3342 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 642934440 XM_008199442.1 78 1.90397e-29 PREDICTED: Tribolium castaneum nucleosome-remodeling factor subunit NURF301 (LOC100141790), transcript variant X3, mRNA K11728 BPTF, E(bx) nucleosome-remodeling factor subunit BPTF http://www.genome.jp/dbget-bin/www_bget?ko:K11728 Q9W0T1 1262 1.2e-136 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF08392//PF12125//PF00628//PF02178 FAE1/Type III polyketide synthase-like protein//D domain of beta-TrCP//PHD-finger//AT hook motif GO:0006633 fatty acid biosynthetic process GO:0003677//GO:0016747//GO:0005515//GO:0046983 DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//protein dimerization activity GO:0016020 membrane KOG1473 Nucleosome remodeling factor, subunit NURF301/BPTF Cluster-8309.47008 BP_3 478.95 1.51 15567 642934439 XP_008197663.1 5485 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 242013552 XM_002427424.1 127 1.79075e-56 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1486 2.0e-162 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00155//PF02178//PF13639//PF12125//PF00439//PF16866//PF00628//PF00202 Aminotransferase class I and II//AT hook motif//Ring finger domain//D domain of beta-TrCP//Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III GO:0009058 biosynthetic process GO:0003677//GO:0008270//GO:0008483//GO:0005515//GO:0046983//GO:0030170 DNA binding//zinc ion binding//transaminase activity//protein binding//protein dimerization activity//pyridoxal phosphate binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.47009 BP_3 584.38 1.84 15581 642934439 XP_008197663.1 5552 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 242013552 XM_002427424.1 127 1.79236e-56 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1507 7.5e-165 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00439//PF00628//PF16866//PF00202//PF02178//PF00155//PF13639//PF12125 Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III//AT hook motif//Aminotransferase class I and II//Ring finger domain//D domain of beta-TrCP GO:0009058 biosynthetic process GO:0008270//GO:0003677//GO:0046983//GO:0030170//GO:0008483//GO:0005515 zinc ion binding//DNA binding//protein dimerization activity//pyridoxal phosphate binding//transaminase activity//protein binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.47011 BP_3 22.64 0.41 2924 91094595 XP_970633.1 1466 1.9e-159 PREDICTED: cytochrome P450 6k1 [Tribolium castaneum]>gi|270016411|gb|EFA12857.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 966 7.6e-103 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0005506//GO:0020037//GO:0016705 metal ion binding//oxidoreductase activity//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.47012 BP_3 12416.72 84.42 7381 642918516 XP_008191506.1 2911 0.0e+00 PREDICTED: angiopoietin-4 [Tribolium castaneum] 755982309 XM_011311561.1 246 5.97344e-123 PREDICTED: Fopius arisanus angiopoietin-related protein 2 (LOC105270540), mRNA -- -- -- -- Q9U8W7 556 6.7e-55 Techylectin-5B OS=Tachypleus tridentatus PE=1 SV=1 PF04111//PF05615//PF08702//PF04513//PF00137 Autophagy protein Apg6//Tho complex subunit 7//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//ATP synthase subunit C GO:0030168//GO:0015991//GO:0006397//GO:0015992//GO:0006914//GO:0051258//GO:0007165 platelet activation//ATP hydrolysis coupled proton transport//mRNA processing//proton transport//autophagy//protein polymerization//signal transduction GO:0030674//GO:0005102//GO:0015078//GO:0005198 protein binding, bridging//receptor binding//hydrogen ion transmembrane transporter activity//structural molecule activity GO:0019031//GO:0005577//GO:0000445//GO:0033177//GO:0019028 viral envelope//fibrinogen complex//THO complex part of transcription export complex//proton-transporting two-sector ATPase complex, proton-transporting domain//viral capsid KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.47013 BP_3 400.61 5.04 4123 642926286 XP_008194862.1 2731 5.6e-306 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like [Tribolium castaneum] 642926285 XM_008196640.1 273 3.25548e-138 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1579 8.8e-174 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF07714//PF01392//PF00069 Protein tyrosine kinase//Fz domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.47015 BP_3 34.78 0.32 5485 237681145 NP_001153717.1 4861 0.0e+00 ATPase, class II, type 9B [Tribolium castaneum]>gi|642928770|ref|XP_008195554.1| PREDICTED: ATPase, class II, type 9B isoform X1 [Tribolium castaneum]>gi|270010392|gb|EFA06840.1| hypothetical protein TcasGA2_TC009783 [Tribolium castaneum] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3531 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF00122//PF09003 E1-E2 ATPase//Bacteriophage lambda integrase, N-terminal domain GO:0015074//GO:0015917//GO:0006812//GO:0015914//GO:0008152 DNA integration//aminophospholipid transport//cation transport//phospholipid transport//metabolic process GO:0046872//GO:0008907//GO:0000287//GO:0000166//GO:0015662//GO:0004012//GO:0003677//GO:0005524 metal ion binding//integrase activity//magnesium ion binding//nucleotide binding//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//phospholipid-translocating ATPase activity//DNA binding//ATP binding GO:0016021 integral component of membrane KOG0210 P-type ATPase Cluster-8309.47021 BP_3 1668.32 27.59 3206 642922662 XP_008193267.1 1184 1.1e-126 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 867 2.5e-91 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067//PF12822 Cytochrome P450//Protein of unknown function (DUF3816) GO:0055114//GO:0006810 oxidation-reduction process//transport GO:0016705//GO:0020037//GO:0005215//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//transporter activity//iron ion binding -- -- -- -- Cluster-8309.47022 BP_3 12.46 0.71 1133 642921027 XP_008192660.1 721 1.8e-73 PREDICTED: protein kinase C-binding protein NELL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92832 278 1.8e-23 Protein kinase C-binding protein NELL1 OS=Homo sapiens GN=NELL1 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47023 BP_3 139.60 4.30 1858 642919704 XP_008192030.1 1785 1.3e-196 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] 807042760 XM_012306425.1 116 2.74128e-51 PREDICTED: Ceratitis capitata serine/threonine-protein kinase par-1 (LOC101453227), transcript variant X3, mRNA K16311 SIK2 serine/threonine-protein kinase SIK2 http://www.genome.jp/dbget-bin/www_bget?ko:K16311 Q9H0K1 1243 3.6e-135 Serine/threonine-protein kinase SIK2 OS=Homo sapiens GN=SIK2 PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0586 Serine/threonine protein kinase Cluster-8309.47027 BP_3 149.52 1.21 6226 270012280 EFA08728.1 711 1.5e-71 hypothetical protein TcasGA2_TC006403 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80VL1 172 1.9e-10 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF04277//PF15802 Oxaloacetate decarboxylase, gamma chain//DDB1- and CUL4-associated factor 17 GO:0016567//GO:0006560//GO:0006525//GO:0006814//GO:0071436//GO:0006090 protein ubiquitination//proline metabolic process//arginine metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.47029 BP_3 704.72 30.98 1388 546676966 ERL87890.1 603 1.1e-59 hypothetical protein D910_05278 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47032 BP_3 957.11 24.77 2154 270001223 EEZ97670.1 186 3.8e-11 hypothetical protein TcasGA2_TC016215 [Tribolium castaneum] 642937522 XM_008200859.1 67 5.52392e-24 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47034 BP_3 489.58 6.18 4112 91087255 XP_975528.1 1116 1.0e-118 PREDICTED: transmembrane protein 110 [Tribolium castaneum]>gi|270009551|gb|EFA05999.1| hypothetical protein TcasGA2_TC008825 [Tribolium castaneum] 847108462 XR_001170156.1 36 1.8156e-06 PREDICTED: Xenopus (Silurana) tropicalis transmembrane protein 110 (tmem110), transcript variant X1, misc_RNA -- -- -- -- Q86TL2 556 3.7e-55 Transmembrane protein 110 OS=Homo sapiens GN=TMEM110 PE=2 SV=1 PF01708//PF01529 Geminivirus putative movement protein//DHHC palmitoyltransferase GO:0046740 transport of virus in host, cell to cell GO:0008270 zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.47038 BP_3 719.52 6.58 5565 167234451 NP_001107840.1 4552 0.0e+00 Dicer-2 [Tribolium castaneum]>gi|642913971|ref|XP_008201496.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|642913973|ref|XP_008201497.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|270002830|gb|EEZ99277.1| hypothetical protein TcasGA2_TC001108 [Tribolium castaneum] 642913972 XM_008203275.1 50 4.06326e-14 PREDICTED: Tribolium castaneum Dicer-2 (Dcr-2), transcript variant X2, mRNA -- -- -- -- P34529 1074 4.3e-115 Endoribonuclease dcr-1 OS=Caenorhabditis elegans GN=dcr-1 PE=1 SV=3 PF00636//PF03368//PF04851//PF02170//PF14622//PF00270 Ribonuclease III domain//Dicer dimerisation domain//Type III restriction enzyme, res subunit//PAZ domain//Ribonuclease-III-like//DEAD/DEAH box helicase GO:0034470//GO:0051252//GO:0006396//GO:0016072 ncRNA processing//regulation of RNA metabolic process//RNA processing//rRNA metabolic process GO:0005515//GO:0004386//GO:0003723//GO:0005524//GO:0016787//GO:0003677//GO:0004525//GO:0043167//GO:0016891//GO:0003676 protein binding//helicase activity//RNA binding//ATP binding//hydrolase activity//DNA binding//ribonuclease III activity//ion binding//endoribonuclease activity, producing 5'-phosphomonoesters//nucleic acid binding -- -- KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.47039 BP_3 247.11 2.64 4802 189235133 XP_966882.2 3063 0.0e+00 PREDICTED: EH domain-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270003802|gb|EFA00250.1| hypothetical protein TcasGA2_TC003079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDI1 547 4.8e-54 EH domain-binding protein 1 OS=Homo sapiens GN=EHBP1 PE=1 SV=3 PF05366//PF00307 Sarcolipin//Calponin homology (CH) domain -- -- GO:0005515//GO:0030234 protein binding//enzyme regulator activity GO:0016020 membrane -- -- Cluster-8309.47041 BP_3 375.00 6.79 2955 642930268 XP_008196323.1 2286 1.6e-254 PREDICTED: digestive organ expansion factor homolog [Tribolium castaneum]>gi|270009436|gb|EFA05884.1| hypothetical protein TcasGA2_TC008696 [Tribolium castaneum] -- -- -- -- -- K14774 UTP25, DEF U3 small nucleolar RNA-associated protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K14774 Q68CQ4 1490 1.3e-163 Digestive organ expansion factor homolog OS=Homo sapiens GN=DIEXF PE=1 SV=2 PF06862 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 -- -- -- -- GO:0005634 nucleus KOG2340 Uncharacterized conserved protein Cluster-8309.47044 BP_3 180.81 5.31 1932 91082667 XP_966596.1 342 2.8e-29 PREDICTED: uncharacterized protein LOC659832 [Tribolium castaneum]>gi|270014970|gb|EFA11418.1| hypothetical protein TcasGA2_TC013595 [Tribolium castaneum] 642910857 XM_961503.3 73 2.28456e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659832 (LOC659832), mRNA -- -- -- -- -- -- -- -- PF05808 Podoplanin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47045 BP_3 21.00 4.30 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47046 BP_3 161.77 4.00 2239 478256087 ENN76286.1 2299 3.8e-256 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 1467 4.7e-161 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF00733//PF00764//PF02568 Asparagine synthase//Arginosuccinate synthase//Thiamine biosynthesis protein (ThiI) GO:0006526//GO:0006529//GO:0006531//GO:0006560//GO:0006522//GO:0008033 arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process//alanine metabolic process//tRNA processing GO:0005524//GO:0004810//GO:0004055//GO:0004066 ATP binding//tRNA adenylyltransferase activity//argininosuccinate synthase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.47047 BP_3 12.06 0.56 1321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47048 BP_3 698.35 8.84 4100 642930410 XP_008196388.1 3749 0.0e+00 PREDICTED: presequence protease, mitochondrial [Tribolium castaneum]>gi|270010721|gb|EFA07169.1| hypothetical protein TcasGA2_TC010168 [Tribolium castaneum] -- -- -- -- -- K06972 K06972 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06972 Q9V9E3 2309 2.0e-258 Presequence protease, mitochondrial OS=Drosophila melanogaster GN=CG3107 PE=2 SV=2 PF08397//PF08367 IRSp53/MIM homology domain//Peptidase M16C associated GO:0006508//GO:0007009 proteolysis//plasma membrane organization GO:0008270//GO:0004222//GO:0046872 zinc ion binding//metalloendopeptidase activity//metal ion binding -- -- KOG2019 Metalloendoprotease HMP1 (insulinase superfamily) Cluster-8309.47049 BP_3 151.22 9.38 1069 759001854 AJP08639.1 1203 2.2e-129 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 317 2.86391e-163 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1096 2.3e-118 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF06293//PF00069//PF03242 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Late embryogenesis abundant protein GO:0006950//GO:0006468 response to stress//protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.47051 BP_3 267.00 14.87 1157 189238165 XP_973195.2 374 3.2e-33 PREDICTED: serine protease gd-like [Tribolium castaneum]>gi|642925379|ref|XP_008194524.1| PREDICTED: serine protease gd-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47052 BP_3 287.15 6.85 2311 642933063 XP_008197247.1 1689 2.1e-185 PREDICTED: rab GTPase-binding effector protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35551 370 7.7e-34 Rab GTPase-binding effector protein 1 OS=Mus musculus GN=Rabep1 PE=1 SV=2 PF03528 Rabaptin GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0005096//GO:0008083 GTPase activator activity//growth factor activity -- -- KOG0993 Rab5 GTPase effector Rabaptin-5 Cluster-8309.47053 BP_3 132435.00 8330.40 1058 225543480 NP_001139387.1 525 9.1e-51 cuticular protein-like precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.47054 BP_3 136.69 1.71 4140 546686080 ERL95480.1 797 1.0e-81 hypothetical protein D910_12742 [Dendroctonus ponderosae] -- -- -- -- -- K03434 PIGL N-acetylglucosaminylphosphatidylinositol deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K03434 Q9Y2B2 434 5.2e-41 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase OS=Homo sapiens GN=PIGL PE=1 SV=1 PF04144 SCAMP family GO:0015031 protein transport -- -- GO:0016021 integral component of membrane KOG3332 N-acetylglucosaminyl phosphatidylinositol de-N-acetylase Cluster-8309.47055 BP_3 3030.97 133.02 1390 91081285 XP_967895.1 685 3.4e-69 PREDICTED: soma ferritin [Tribolium castaneum]>gi|270005213|gb|EFA01661.1| hypothetical protein TcasGA2_TC007233 [Tribolium castaneum] -- -- -- -- -- K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 P42577 552 3.6e-55 Soma ferritin OS=Lymnaea stagnalis PE=2 SV=2 PF00210//PF02915 Ferritin-like domain//Rubrerythrin GO:0006826//GO:0055114//GO:0006879 iron ion transport//oxidation-reduction process//cellular iron ion homeostasis GO:0016491//GO:0046872//GO:0008199 oxidoreductase activity//metal ion binding//ferric iron binding -- -- KOG2332 Ferritin Cluster-8309.47057 BP_3 331.44 4.22 4074 478249815 ENN70322.1 784 3.3e-80 hypothetical protein YQE_12833, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PR54 158 5.2e-09 Telomere-associated protein RIF1 OS=Mus musculus GN=Rif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47059 BP_3 89.79 1.26 3737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00220 Neurohypophysial hormones, N-terminal Domain GO:0007218 neuropeptide signaling pathway GO:0005185 neurohypophyseal hormone activity GO:0005576 extracellular region -- -- Cluster-8309.4706 BP_3 21.08 0.47 2473 531446815 AGT57845.1 476 1.0e-44 cytochrome P450 334e3, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V5L3 141 3.0e-07 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.47061 BP_3 41.59 0.57 3785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.47062 BP_3 253.26 2.34 5516 815769352 XP_012234789.1 1736 1.8e-190 PREDICTED: synaptotagmin-7 isoform X1 [Linepithema humile]>gi|815769354|ref|XP_012234790.1| PREDICTED: synaptotagmin-7 isoform X1 [Linepithema humile] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 870 1.9e-91 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168//PF04545 C2 domain//Sigma-70, region 4 GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0005515//GO:0016987//GO:0003677 transcription factor activity, sequence-specific DNA binding//protein binding//sigma factor activity//DNA binding GO:0005667 transcription factor complex KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.47063 BP_3 166.18 4.52 2065 571330974 AHF27419.1 1063 7.3e-113 putative sugar transporter 5 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A9ZSY2 627 1.1e-63 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.47064 BP_3 159.32 3.49 2491 817182773 XP_012272816.1 326 2.6e-27 PREDICTED: uncharacterized protein LOC105695640 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.47065 BP_3 84.13 1.86 2474 817182773 XP_012272816.1 326 2.5e-27 PREDICTED: uncharacterized protein LOC105695640 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.47066 BP_3 291.85 4.62 3335 642914128 XP_008201556.1 3030 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 586 1.0e-58 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 PF00404//PF13405//PF00036//PF13499//PF13202 Dockerin type I repeat//EF-hand domain//EF hand//EF-hand domain pair//EF hand GO:0005975 carbohydrate metabolic process GO:0004553//GO:0005509 hydrolase activity, hydrolyzing O-glycosyl compounds//calcium ion binding -- -- -- -- Cluster-8309.47067 BP_3 8132.36 64.18 6399 91080811 XP_970116.1 1778 2.8e-195 PREDICTED: ufm1-specific protease 2 [Tribolium castaneum]>gi|270005426|gb|EFA01874.1| hypothetical protein TcasGA2_TC007479 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M1D1 1045 1.1e-111 Probable Ufm1-specific protease 2 OS=Drosophila pseudoobscura pseudoobscura GN=UFSP2 PE=3 SV=1 PF03847//PF00125//PF00089//PF02285 Transcription initiation factor TFIID subunit A//Core histone H2A/H2B/H3/H4//Trypsin//Cytochrome oxidase c subunit VIII GO:0006352//GO:0015992//GO:0006508//GO:0006123 DNA-templated transcription, initiation//proton transport//proteolysis//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0004252//GO:0003677 cytochrome-c oxidase activity//serine-type endopeptidase activity//DNA binding GO:0005669//GO:0045277 transcription factor TFIID complex//respiratory chain complex IV KOG2433 Uncharacterized conserved protein Cluster-8309.47068 BP_3 658.33 4.37 7549 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 9.0e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF00071//PF02421//PF01926//PF07817//PF03810//PF08477//PF03193 Ras family//Ferrous iron transport protein B//50S ribosome-binding GTPase//GLE1-like protein//Importin-beta N-terminal domain//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0007264//GO:0015684//GO:0015031//GO:0016973//GO:0006886 small GTPase mediated signal transduction//ferrous iron transport//protein transport//poly(A)+ mRNA export from nucleus//intracellular protein transport GO:0005525//GO:0008565//GO:0015093//GO:0008536//GO:0003924 GTP binding//protein transporter activity//ferrous iron transmembrane transporter activity//Ran GTPase binding//GTPase activity GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.47069 BP_3 72.09 3.24 1365 642910295 XP_008200272.1 367 2.5e-32 PREDICTED: beta-N-acetylglucosaminidase NAG2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P49010 294 3.0e-25 Chitooligosaccharidolytic beta-N-acetylglucosaminidase OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.47070 BP_3 76.96 1.24 3293 642925685 XP_008194669.1 1150 9.6e-123 PREDICTED: aminomethyltransferase, mitochondrial [Tribolium castaneum]>gi|270008909|gb|EFA05357.1| hypothetical protein TcasGA2_TC015522 [Tribolium castaneum] -- -- -- -- -- K00605 gcvT, AMT aminomethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00605 P25285 762 3.9e-79 Aminomethyltransferase, mitochondrial OS=Bos taurus GN=AMT PE=1 SV=1 -- -- GO:0006546//GO:0006544//GO:0006563//GO:0006566 glycine catabolic process//glycine metabolic process//L-serine metabolic process//threonine metabolic process GO:0008483//GO:0004047 transaminase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2770 Aminomethyl transferase Cluster-8309.47071 BP_3 217.04 6.68 1857 642925685 XP_008194669.1 1435 4.8e-156 PREDICTED: aminomethyltransferase, mitochondrial [Tribolium castaneum]>gi|270008909|gb|EFA05357.1| hypothetical protein TcasGA2_TC015522 [Tribolium castaneum] -- -- -- -- -- K00605 gcvT, AMT aminomethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00605 P25285 942 2.9e-100 Aminomethyltransferase, mitochondrial OS=Bos taurus GN=AMT PE=1 SV=1 -- -- GO:0006544//GO:0006546//GO:0006566//GO:0006563 glycine metabolic process//glycine catabolic process//threonine metabolic process//L-serine metabolic process GO:0008483//GO:0004047 transaminase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2770 Aminomethyl transferase Cluster-8309.47075 BP_3 464.45 10.94 2338 478253832 ENN74124.1 1593 2.9e-174 hypothetical protein YQE_09097, partial [Dendroctonus ponderosae]>gi|546684638|gb|ERL94255.1| hypothetical protein D910_11536 [Dendroctonus ponderosae] 749785289 XM_011148089.1 84 2.12893e-33 PREDICTED: Harpegnathos saltator probable E3 ubiquitin-protein ligase makorin-1 (LOC105187344), mRNA K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q5NU14 754 2.3e-78 Probable E3 ubiquitin-protein ligase makorin-1 OS=Takifugu rubripes GN=mkrn1 PE=2 SV=1 PF14634//PF12861//PF12678//PF00642//PF00097//PF16954//PF13639 zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Zinc finger, C3HC4 type (RING finger)//Haem-transporter, endosomal/lysosomal, haem-responsive gene//Ring finger domain GO:0016567//GO:0015886 protein ubiquitination//heme transport GO:0005515//GO:0004842//GO:0015232//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//heme transporter activity//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG1039 Predicted E3 ubiquitin ligase Cluster-8309.47076 BP_3 612.00 2.89 10509 91088841 XP_970807.1 2162 1.4e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.63921e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 6.0e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF00628//PF00538//PF01853//PF06431//PF01160//PF13508 PHD-finger//linker histone H1 and H5 family//MOZ/SAS family//Polyomavirus large T antigen C-terminus//Vertebrate endogenous opioids neuropeptide//Acetyltransferase (GNAT) domain GO:0042967//GO:0006334//GO:0007218//GO:0006260//GO:0006355 acyl-carrier-protein biosynthetic process//nucleosome assembly//neuropeptide signaling pathway//DNA replication//regulation of transcription, DNA-templated GO:0005515//GO:0008080//GO:0003677//GO:0005524//GO:0016747//GO:0005488 protein binding//N-acetyltransferase activity//DNA binding//ATP binding//transferase activity, transferring acyl groups other than amino-acyl groups//binding GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.47077 BP_3 615.91 6.14 5128 91083351 XP_975052.1 2637 5.6e-295 PREDICTED: gamma-tubulin complex component 3 [Tribolium castaneum]>gi|270007769|gb|EFA04217.1| hypothetical protein TcasGA2_TC014466 [Tribolium castaneum] -- -- -- -- -- K16570 TUBGCP3, GCP3 gamma-tubulin complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16570 P58854 1192 8.3e-129 Gamma-tubulin complex component 3 OS=Mus musculus GN=Tubgcp3 PE=2 SV=2 PF04130 Spc97 / Spc98 family GO:0090063//GO:0000226 positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0005815//GO:0000922//GO:0044430//GO:0015630 microtubule organizing center//spindle pole//cytoskeletal part//microtubule cytoskeleton KOG2000 Gamma-tubulin complex, DGRIP91/SPC98 component Cluster-8309.47078 BP_3 10.08 0.51 1245 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47079 BP_3 843.41 8.71 4958 91088253 XP_966567.1 1655 4.0e-181 PREDICTED: ankyrin repeat and zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270012152|gb|EFA08600.1| hypothetical protein TcasGA2_TC006259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPJ0 627 2.6e-63 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF13606//PF00023//PF01553//PF15306 Ankyrin repeat//Ankyrin repeat//Acyltransferase//LIN37 GO:0008152//GO:0007049 metabolic process//cell cycle GO:0005515//GO:0016746 protein binding//transferase activity, transferring acyl groups GO:0017053 transcriptional repressor complex KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.4708 BP_3 21.00 0.49 2354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04715 Anthranilate synthase component I, N terminal region GO:0009058 biosynthetic process GO:0016833 oxo-acid-lyase activity -- -- -- -- Cluster-8309.47080 BP_3 635.09 6.75 4829 91088253 XP_966567.1 1655 3.9e-181 PREDICTED: ankyrin repeat and zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270012152|gb|EFA08600.1| hypothetical protein TcasGA2_TC006259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPJ0 627 2.5e-63 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF13606//PF06072//PF00023//PF01553//PF15306 Ankyrin repeat//Alphaherpesvirus tegument protein US9//Ankyrin repeat//Acyltransferase//LIN37 GO:0008152//GO:0007049 metabolic process//cell cycle GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0017053//GO:0019033 transcriptional repressor complex//viral tegument KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.47083 BP_3 36.79 1.24 1726 478251085 ENN71561.1 1380 1.1e-149 hypothetical protein YQE_11663, partial [Dendroctonus ponderosae] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q5RAS0 1123 2.8e-121 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Pongo abelii GN=ACADS PE=2 SV=1 PF02771//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050660//GO:0016627 flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.47086 BP_3 1474.84 26.07 3018 270015051 EFA11499.1 1436 6.0e-156 hypothetical protein TcasGA2_TC014213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2C3 393 2.2e-36 Beta-1,3-galactosyltransferase 5 OS=Homo sapiens GN=B3GALT5 PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG2287 Galactosyltransferases Cluster-8309.47088 BP_3 13.00 1.71 658 91088697 XP_975033.1 140 2.5e-06 PREDICTED: uncharacterized protein LOC663911 [Tribolium castaneum]>gi|270011669|gb|EFA08117.1| hypothetical protein TcasGA2_TC005721 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.4709 BP_3 2.00 0.52 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47090 BP_3 14.72 0.34 2390 91082195 XP_971684.1 1231 2.8e-132 PREDICTED: nipped-B-like protein B [Tribolium castaneum]>gi|270007443|gb|EFA03891.1| hypothetical protein TcasGA2_TC014015 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09034 TRADD, N-terminal domain GO:0007165//GO:0043123 signal transduction//positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0004871//GO:0005515 signal transducer activity//protein binding -- -- -- -- Cluster-8309.47091 BP_3 3048.00 53.93 3016 642921295 XP_008192806.1 1217 1.5e-130 PREDICTED: uncharacterized protein LOC103312850 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47093 BP_3 797.61 9.50 4337 270003958 EFA00406.1 1857 1.3e-204 hypothetical protein TcasGA2_TC003257 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 P81274 1369 2.1e-149 G-protein-signaling modulator 2 OS=Homo sapiens GN=GPSM2 PE=1 SV=3 PF00515//PF13374//PF13414//PF13176//PF10579//PF07721//PF13181//PF05194 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Tetratricopeptide repeat//UreE urease accessory protein, C-terminal domain GO:0019627//GO:0007268//GO:0006461 urea metabolic process//synaptic transmission//protein complex assembly GO:0042802//GO:0033130//GO:0016151//GO:0005515//GO:0043495 identical protein binding//acetylcholine receptor binding//nickel cation binding//protein binding//protein anchor -- -- KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain Cluster-8309.47096 BP_3 60.68 1.14 2853 642934335 XP_969733.2 2663 3.0e-298 PREDICTED: tripartite motif-containing protein 2 isoform X5 [Tribolium castaneum] 817086197 XM_012410395.1 92 9.29701e-38 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 O75382 362 8.0e-33 Tripartite motif-containing protein 3 OS=Homo sapiens GN=TRIM3 PE=1 SV=2 PF01580//PF02601//PF13639//PF01637//PF05149//PF09815//PF01436//PF05524//PF00643//PF14634//PF05929//PF00097 FtsK/SpoIIIE family//Exonuclease VII, large subunit//Ring finger domain//Archaeal ATPase//Paraflagellar rod protein//XK-related protein//NHL repeat//PEP-utilising enzyme, N-terminal//B-box zinc finger//zinc-RING finger domain//Phage capsid scaffolding protein (GPO) serine peptidase//Zinc finger, C3HC4 type (RING finger) GO:0006308//GO:0019069//GO:0009401 DNA catabolic process//viral capsid assembly//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0008855//GO:0003677//GO:0005524//GO:0005516//GO:0046872//GO:0008270//GO:0000166 protein binding//exodeoxyribonuclease VII activity//DNA binding//ATP binding//calmodulin binding//metal ion binding//zinc ion binding//nucleotide binding GO:0031514//GO:0016021//GO:0005622//GO:0009318 motile cilium//integral component of membrane//intracellular//exodeoxyribonuclease VII complex -- -- Cluster-8309.47097 BP_3 69.11 1.23 3002 332376741 AEE63510.1 552 1.9e-53 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q9QXF8 270 3.9e-22 Glycine N-methyltransferase OS=Mus musculus GN=Gnmt PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47098 BP_3 927.47 7.96 5906 642918478 XP_008191493.1 5390 0.0e+00 PREDICTED: epidermal growth factor receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K04361 EGFR, ERBB1 epidermal growth factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04361 P0CY46 4398 0.0e+00 Epidermal growth factor receptor OS=Apis mellifera GN=Egfr PE=2 SV=1 PF00757//PF07714//PF06293//PF00069 Furin-like cysteine rich region//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0016773//GO:0004672//GO:0004714 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-8309.471 BP_3 6.00 1.24 524 719769482 XP_010218741.1 749 4.8e-77 PREDICTED: LOW QUALITY PROTEIN: KRAB-A domain-containing protein 2, partial [Tinamus guttatus] 258644652 AP009091.1 509 0 Oryza sativa Indica Group DNA, chromosome 8, BAC clone: K0155E09 K01301 NAALAD N-acetylated-alpha-linked acidic dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01301 P0CT40 292 1.9e-25 Transposon Tf2-9 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-9 PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.47101 BP_3 33.90 1.24 1612 546682476 ERL92399.1 940 1.0e-98 hypothetical protein D910_09713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V0D5 434 2.0e-41 Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1 PF02402//PF02615 Lysis protein//Malate/L-lactate dehydrogenase GO:0055114//GO:0008152//GO:0009405//GO:0019835 oxidation-reduction process//metabolic process//pathogenesis//cytolysis GO:0016491 oxidoreductase activity GO:0019867 outer membrane -- -- Cluster-8309.47106 BP_3 96.15 1.97 2640 270017024 EFA13470.1 982 2.3e-103 hypothetical protein TcasGA2_TC001911 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 300 1.2e-25 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.47107 BP_3 138.85 2.65 2813 270017024 EFA13470.1 983 1.9e-103 hypothetical protein TcasGA2_TC001911 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 300 1.2e-25 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.47113 BP_3 336.03 2.99 5708 642912871 XP_008201290.1 4729 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X7 [Tribolium castaneum] 642912874 XM_008203070.1 1284 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1804 9.9e-200 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00609//PF00130//PF00788//PF00781//PF00076//PF00628//PF07649 Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PHD-finger//C1-like domain GO:0035556//GO:0055114//GO:0046486//GO:0007165//GO:0009395//GO:0007205 intracellular signal transduction//oxidation-reduction process//glycerolipid metabolic process//signal transduction//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway GO:0003676//GO:0016301//GO:0047134//GO:0004143//GO:0005515 nucleic acid binding//kinase activity//protein-disulfide reductase activity//diacylglycerol kinase activity//protein binding -- -- KOG1169 Diacylglycerol kinase Cluster-8309.47115 BP_3 32.90 0.37 4566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10729 Cell division activator CedA GO:0051301 cell division GO:0003677 DNA binding -- -- -- -- Cluster-8309.47116 BP_3 87.87 0.70 6330 270010053 EFA06501.1 2365 2.4e-263 hypothetical protein TcasGA2_TC009400 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 957 1.8e-101 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF00665//PF05225//PF00098 Integrase core domain//helix-turn-helix, Psq domain//Zinc knuckle GO:0015074 DNA integration GO:0008270//GO:0003677//GO:0003676 zinc ion binding//DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.47117 BP_3 166.06 1.17 7141 270010053 EFA06501.1 2365 2.7e-263 hypothetical protein TcasGA2_TC009400 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 957 2.0e-101 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF05225//PF00098//PF00665 helix-turn-helix, Psq domain//Zinc knuckle//Integrase core domain GO:0015074 DNA integration GO:0008270//GO:0003676//GO:0003677 zinc ion binding//nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.47119 BP_3 384.53 2.93 6617 189239223 XP_973572.2 678 1.0e-67 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 1.23467e-74 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF05115 Cytochrome B6-F complex subunit VI (PetL) GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.47120 BP_3 689.57 14.13 2644 189240891 XP_971710.2 3065 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Bre1 [Tribolium castaneum]>gi|270013497|gb|EFA09945.1| hypothetical protein TcasGA2_TC012098 [Tribolium castaneum] 195552621 XM_002076477.1 132 5.00368e-60 Drosophila simulans GD17597 (Dsim\GD17597), mRNA K10696 BRE1 E3 ubiquitin-protein ligase BRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10696 Q9VRP9 2307 2.2e-258 E3 ubiquitin-protein ligase Bre1 OS=Drosophila melanogaster GN=Bre1 PE=1 SV=2 PF17078//PF16331//PF04111//PF04739//PF07926//PF04632 SWI5-dependent HO expression protein 3//TolA binding protein trimerisation//Autophagy protein Apg6//5'-AMP-activated protein kinase beta subunit, interaction domain//TPR/MLP1/MLP2-like protein//Fusaric acid resistance protein family GO:0048309//GO:0006810//GO:0070206//GO:0006914//GO:0051028//GO:0006606 endoplasmic reticulum inheritance//transport//protein trimerization//autophagy//mRNA transport//protein import into nucleus GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding GO:0005886 plasma membrane KOG0978 E3 ubiquitin ligase involved in syntaxin degradation Cluster-8309.47121 BP_3 247.00 20.03 886 189240891 XP_971710.2 1244 3.2e-134 PREDICTED: E3 ubiquitin-protein ligase Bre1 [Tribolium castaneum]>gi|270013497|gb|EFA09945.1| hypothetical protein TcasGA2_TC012098 [Tribolium castaneum] 642934616 XM_966617.3 360 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase Bre1 (LOC660381), mRNA K10696 BRE1 E3 ubiquitin-protein ligase BRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10696 Q9VRP9 1145 4.0e-124 E3 ubiquitin-protein ligase Bre1 OS=Drosophila melanogaster GN=Bre1 PE=1 SV=2 PF13639//PF14634//PF12861//PF12678//PF00097 Ring finger domain//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0978 E3 ubiquitin ligase involved in syntaxin degradation Cluster-8309.47122 BP_3 38.43 0.77 2695 189240891 XP_971710.2 3088 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Bre1 [Tribolium castaneum]>gi|270013497|gb|EFA09945.1| hypothetical protein TcasGA2_TC012098 [Tribolium castaneum] 195552621 XM_002076477.1 132 5.09797e-60 Drosophila simulans GD17597 (Dsim\GD17597), mRNA K10696 BRE1 E3 ubiquitin-protein ligase BRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10696 Q9VRP9 2331 3.7e-261 E3 ubiquitin-protein ligase Bre1 OS=Drosophila melanogaster GN=Bre1 PE=1 SV=2 PF04632//PF07926//PF04739//PF04111//PF16331 Fusaric acid resistance protein family//TPR/MLP1/MLP2-like protein//5'-AMP-activated protein kinase beta subunit, interaction domain//Autophagy protein Apg6//TolA binding protein trimerisation GO:0006606//GO:0006914//GO:0070206//GO:0006810 protein import into nucleus//autophagy//protein trimerization//transport GO:0046872//GO:0008270//GO:0005515 metal ion binding//zinc ion binding//protein binding GO:0005886 plasma membrane KOG0978 E3 ubiquitin ligase involved in syntaxin degradation Cluster-8309.47123 BP_3 32.00 3.01 804 514683686 XP_004989424.1 163 6.5e-09 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF04988//PF02150 Zinc-finger double domain//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//RNA polymerases M/15 Kd subunit GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.47124 BP_3 667.44 9.15 3808 91079074 XP_975225.1 1006 5.5e-106 PREDICTED: ras-related protein Rab-10 [Tribolium castaneum]>gi|270003655|gb|EFA00103.1| hypothetical protein TcasGA2_TC002919 [Tribolium castaneum] 642916371 XM_970132.3 262 3.91425e-132 PREDICTED: Tribolium castaneum ras-related protein Rab-10 (LOC664117), mRNA K07903 RAB10 Ras-related protein Rab-10 http://www.genome.jp/dbget-bin/www_bget?ko:K07903 P22127 812 7.1e-85 Ras-related protein Rab-10 OS=Diplobatis ommata PE=2 SV=1 PF01926//PF04344//PF08477//PF03193//PF00025//PF04670//PF00071 50S ribosome-binding GTPase//Chemotaxis phosphatase, CheZ//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family GO:0050920//GO:0007264//GO:0015031 regulation of chemotaxis//small GTPase mediated signal transduction//protein transport GO:0003824//GO:0005525//GO:0003924 catalytic activity//GTP binding//GTPase activity GO:0009288 bacterial-type flagellum KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.47125 BP_3 725.82 2.35 15152 826444743 XP_012531039.1 5876 0.0e+00 PREDICTED: voltage-dependent calcium channel type A subunit alpha-1 isoform X7 [Monomorium pharaonis] 259906454 NM_001165911.1 940 0 Tribolium castaneum cacophony A (Cac), mRNA >gnl|BL_ORD_ID|7385018 Tribolium castaneum cacophony A (CAC) mRNA, complete cds -- -- -- -- C9D7C2 3178 0.0e+00 Voltage-dependent calcium channel type A subunit alpha-1 OS=Apis mellifera GN=CAC PE=2 SV=1 PF00230//PF14138//PF13405//PF00036//PF02561//PF01635//PF00520 Major intrinsic protein//Cytochrome c oxidase assembly protein COX16//EF-hand domain//EF hand//Flagellar protein FliS//Coronavirus M matrix/glycoprotein//Ion transport protein GO:0019058//GO:0006810//GO:0055085//GO:0006811 viral life cycle//transport//transmembrane transport//ion transport GO:0005215//GO:0005509//GO:0005216 transporter activity//calcium ion binding//ion channel activity GO:0031966//GO:0009288//GO:0016020 mitochondrial membrane//bacterial-type flagellum//membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.47127 BP_3 889.55 36.61 1463 91079142 XP_975469.1 1492 9.3e-163 PREDICTED: hypoxia-inducible factor 1-alpha inhibitor [Tribolium castaneum]>gi|270004836|gb|EFA01284.1| hypoxia-inducible factor 1, alpha subunit inhibitor [Tribolium castaneum] -- -- -- -- -- K18055 HIF1AN hypoxia-inducible factor 1-alpha inhibitor (HIF hydroxylase) http://www.genome.jp/dbget-bin/www_bget?ko:K18055 Q9NWT6 1105 2.9e-119 Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens GN=HIF1AN PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.47128 BP_3 104.45 1.04 5123 91079142 XP_975469.1 965 4.2e-101 PREDICTED: hypoxia-inducible factor 1-alpha inhibitor [Tribolium castaneum]>gi|270004836|gb|EFA01284.1| hypoxia-inducible factor 1, alpha subunit inhibitor [Tribolium castaneum] -- -- -- -- -- K18055 HIF1AN hypoxia-inducible factor 1-alpha inhibitor (HIF hydroxylase) http://www.genome.jp/dbget-bin/www_bget?ko:K18055 Q9NWT6 839 7.1e-88 Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens GN=HIF1AN PE=1 SV=2 PF06783//PF01191 Uncharacterised protein family (UPF0239)//RNA polymerase Rpb5, C-terminal domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0016021//GO:0005730 integral component of membrane//nucleolus KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.47130 BP_3 150.88 2.33 3417 642933781 XP_008197271.1 2885 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 16 isoform X2 [Tribolium castaneum]>gi|270013594|gb|EFA10042.1| hypothetical protein TcasGA2_TC012214 [Tribolium castaneum] -- -- -- -- -- K09536 DNAJC16 DnaJ homolog subfamily C member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K09536 Q5RCM7 799 2.0e-83 DnaJ homolog subfamily C member 16 OS=Pongo abelii GN=DNAJC16 PE=2 SV=1 PF07961//PF00578//PF00085//PF08534 MBA1-like protein//AhpC/TSA family//Thioredoxin//Redoxin GO:0006457//GO:0032979//GO:0055114//GO:0045454 protein folding//protein insertion into mitochondrial membrane from inner side//oxidation-reduction process//cell redox homeostasis GO:0031072//GO:0016491//GO:0016209//GO:0051082 heat shock protein binding//oxidoreductase activity//antioxidant activity//unfolded protein binding GO:0005743 mitochondrial inner membrane KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.47131 BP_3 12.00 0.33 2048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47132 BP_3 139.17 1.29 5482 859132801 AKO63316.1 1700 2.7e-186 acetyl CoA acetyltransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 1338 1.0e-145 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF02803//PF00108//PF14634 Thiolase, C-terminal domain//Thiolase, N-terminal domain//zinc-RING finger domain GO:0008152 metabolic process GO:0016747//GO:0005515//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//zinc ion binding -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.47135 BP_3 500.43 2.86 8723 642926595 XP_008194933.1 1180 8.4e-126 PREDICTED: fasciclin-3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15278 504 8.4e-49 Fasciclin-3 OS=Drosophila melanogaster GN=Fas3 PE=2 SV=1 PF13895//PF02017//PF09230 Immunoglobulin domain//CIDE-N domain//DNA fragmentation factor 40 kDa GO:0006915//GO:0006309 apoptotic process//apoptotic DNA fragmentation GO:0016787//GO:0005515 hydrolase activity//protein binding GO:0005622//GO:0005634//GO:0005737 intracellular//nucleus//cytoplasm -- -- Cluster-8309.47136 BP_3 91.25 18.30 532 642926597 XP_008194934.1 255 9.3e-20 PREDICTED: fasciclin-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47137 BP_3 2531.16 14.76 8555 642926595 XP_008194933.1 1393 1.7e-150 PREDICTED: fasciclin-3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15278 540 5.5e-53 Fasciclin-3 OS=Drosophila melanogaster GN=Fas3 PE=2 SV=1 PF02017//PF13895//PF13965//PF12539//PF09230 CIDE-N domain//Immunoglobulin domain//dsRNA-gated channel SID-1//Chromosome segregation protein Csm1/Pcs1//DNA fragmentation factor 40 kDa GO:0006915//GO:0033227//GO:0015931//GO:0006309 apoptotic process//dsRNA transport//nucleobase-containing compound transport//apoptotic DNA fragmentation GO:0051033//GO:0016787//GO:0005515 RNA transmembrane transporter activity//hydrolase activity//protein binding GO:0005622//GO:0005737//GO:0016021//GO:0005634 intracellular//cytoplasm//integral component of membrane//nucleus -- -- Cluster-8309.47138 BP_3 71.91 9.36 662 642937521 XP_008199080.1 240 6.4e-18 PREDICTED: heterogeneous nuclear ribonucleoprotein 27C isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04140 Isoprenylcysteine carboxyl methyltransferase (ICMT) family GO:0006479//GO:0006481 protein methylation//C-terminal protein methylation GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47139 BP_3 274.00 12.73 1329 189237653 XP_001811993.1 884 2.7e-92 PREDICTED: rab-like protein 3 [Tribolium castaneum]>gi|270006864|gb|EFA03312.1| hypothetical protein TcasGA2_TC013254 [Tribolium castaneum] -- -- -- -- -- K07933 RABL3 Rab-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07933 Q5ZKR4 554 2.0e-55 Rab-like protein 3 OS=Gallus gallus GN=RABL3 PE=2 SV=1 PF08477//PF05049//PF01926//PF00004//PF00025//PF03193//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//Interferon-inducible GTPase (IIGP)//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//ADP-ribosylation factor family//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity GO:0016020 membrane -- -- Cluster-8309.47142 BP_3 2176.99 61.97 1985 91077256 XP_974061.1 862 1.4e-89 PREDICTED: trypsin-1 [Tribolium castaneum]>gi|270002769|gb|EEZ99216.1| serine protease-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 238 1.3e-18 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF04928//PF01008//PF00089 Poly(A) polymerase central domain//Initiation factor 2 subunit family//Trypsin GO:0006508//GO:0043631//GO:0044237 proteolysis//RNA polyadenylation//cellular metabolic process GO:0004652//GO:0004252//GO:0008233 polynucleotide adenylyltransferase activity//serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.47143 BP_3 1.00 2.87 282 749750016 XP_011137246.1 218 9.6e-16 PREDICTED: thioredoxin reductase 1, mitochondrial-like isoform X2 [Harpegnathos saltator] -- -- -- -- -- K00384 trxB thioredoxin reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00384 P91938 183 4.5e-13 Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 PE=1 SV=2 PF07992//PF00070 Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG4716 Thioredoxin reductase Cluster-8309.47144 BP_3 1050.80 20.40 2774 642923285 XP_008193690.1 2418 7.5e-270 PREDICTED: venom dipeptidyl peptidase 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B1A4F7 1320 6.4e-144 Venom dipeptidyl peptidase 4 OS=Vespula vulgaris PE=1 SV=1 PF00930//PF02129//PF00326 Dipeptidyl peptidase IV (DPP IV) N-terminal region//X-Pro dipeptidyl-peptidase (S15 family)//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.47150 BP_3 26.82 0.46 3093 478259915 ENN79717.1 710 9.4e-72 hypothetical protein YQE_03773, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- D2I2M6 138 8.2e-07 Metallophosphoesterase 1 OS=Ailuropoda melanoleuca GN=MPPE1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3662 Cell division control protein/predicted DNA repair exonuclease Cluster-8309.47152 BP_3 6.07 1.69 464 642919995 XP_008192159.1 659 1.2e-66 PREDICTED: teneurin-m isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O61307 585 1.8e-59 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47154 BP_3 713.94 4.65 7692 642936873 XP_969385.2 1572 2.6e-171 PREDICTED: cdc42-interacting protein 4 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RU3 725 1.8e-74 Formin-binding protein 1 OS=Homo sapiens GN=FNBP1 PE=1 SV=2 PF00018//PF14604//PF02185//PF09177//PF00816 SH3 domain//Variant SH3 domain//Hr1 repeat//Syntaxin 6, N-terminal//H-NS histone family GO:0007165//GO:0006355//GO:0048193 signal transduction//regulation of transcription, DNA-templated//Golgi vesicle transport GO:0003677//GO:0005515 DNA binding//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.47155 BP_3 46.88 0.88 2872 478257994 ENN78132.1 1444 6.7e-157 hypothetical protein YQE_05286, partial [Dendroctonus ponderosae] 815908496 XM_003488754.2 48 2.69605e-13 PREDICTED: Bombus impatiens protein SEC13 homolog (LOC100746611), mRNA K14004 SEC13 protein transport protein SEC13 http://www.genome.jp/dbget-bin/www_bget?ko:K14004 Q9D1M0 1099 2.8e-118 Protein SEC13 homolog OS=Mus musculus GN=Sec13 PE=2 SV=3 PF13606//PF16473//PF00023//PF00400 Ankyrin repeat//Domain of unknown function (DUF5051)//Ankyrin repeat//WD domain, G-beta repeat -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- KOG1332 Vesicle coat complex COPII, subunit SEC13 Cluster-8309.47156 BP_3 180.28 4.71 2138 91078830 XP_971270.1 1311 1.3e-141 PREDICTED: metallophosphoesterase domain-containing protein 1 [Tribolium castaneum]>gi|270004125|gb|EFA00573.1| hypothetical protein TcasGA2_TC003443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q22306 692 3.3e-71 UPF0046 protein T07D4.2 OS=Caenorhabditis elegans GN=T07D4.2 PE=1 SV=3 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3947 Phosphoesterases Cluster-8309.47157 BP_3 4.00 8.90 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47159 BP_3 926.19 9.76 4867 642934675 XP_008197763.1 4351 0.0e+00 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 642934684 XM_008199547.1 110 1.57199e-47 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1576 2.3e-173 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF02542//PF00211 YgbB family//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0016114 cyclic nucleotide biosynthetic process//intracellular signal transduction//terpenoid biosynthetic process GO:0016849//GO:0008685 phosphorus-oxygen lyase activity//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity -- -- -- -- Cluster-8309.47160 BP_3 620.47 12.99 2594 189242404 XP_968940.2 2817 0.0e+00 PREDICTED: palmitoyltransferase ZDHHC5 isoform X2 [Tribolium castaneum] 642939045 XM_963847.3 577 0 PREDICTED: Tribolium castaneum palmitoyltransferase ZDHHC5 (LOC657384), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q2THW9 732 9.1e-76 Palmitoyltransferase ZDHHC5 OS=Canis familiaris GN=ZDHHC5 PE=2 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.47161 BP_3 124.78 0.79 7898 270016265 EFA12711.1 933 3.3e-97 hypothetical protein TcasGA2_TC002345 [Tribolium castaneum] 642939045 XM_963847.3 205 3.95862e-100 PREDICTED: Tribolium castaneum palmitoyltransferase ZDHHC5 (LOC657384), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47162 BP_3 110.78 0.81 6845 546674055 ERL85543.1 387 5.9e-34 hypothetical protein D910_02962 [Dendroctonus ponderosae] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 251 1.4e-19 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF08395//PF07859 7tm Chemosensory receptor//alpha/beta hydrolase fold GO:0050909//GO:0008152 sensory perception of taste//metabolic process GO:0016787 hydrolase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47163 BP_3 22.59 0.31 3861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47164 BP_3 29.06 0.40 3795 642926822 XP_008195028.1 2091 8.5e-232 PREDICTED: pre-mRNA-processing factor 40 homolog A [Tribolium castaneum]>gi|270009175|gb|EFA05623.1| hypothetical protein TcasGA2_TC015831 [Tribolium castaneum] 642926821 XM_008196806.1 308 1.04686e-157 PREDICTED: Tribolium castaneum pre-mRNA-processing factor 40 homolog A (LOC658510), mRNA K12821 PRPF40, PRP40 pre-mRNA-processing factor 40 http://www.genome.jp/dbget-bin/www_bget?ko:K12821 Q6NWY9 1231 1.8e-133 Pre-mRNA-processing factor 40 homolog B OS=Homo sapiens GN=PRPF40B PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0152 Spliceosomal protein FBP11/Splicing factor PRP40 Cluster-8309.47165 BP_3 353.90 15.15 1418 642932331 XP_008197068.1 440 8.8e-41 PREDICTED: uncharacterized protein LOC103314051 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07947//PF00335//PF01284//PF06624//PF03348 YhhN-like protein//Tetraspanin family//Membrane-associating domain//Ribosome associated membrane protein RAMP4//Serine incorporator (Serinc) -- -- -- -- GO:0016021//GO:0016020//GO:0005783 integral component of membrane//membrane//endoplasmic reticulum -- -- Cluster-8309.47166 BP_3 118.13 1.11 5444 642926303 XP_008194869.1 1059 5.6e-112 PREDICTED: GDNF-inducible zinc finger protein 1-like [Tribolium castaneum]>gi|270008503|gb|EFA04951.1| hypothetical protein TcasGA2_TC015019 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJU3 323 5.1e-28 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13912//PF16622//PF05965//PF13465//PF00096 C2H2-type zinc finger//zinc-finger C2H2-type//F/Y rich C-terminus//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0005634 nucleus -- -- Cluster-8309.47169 BP_3 129.95 2.54 2762 642926303 XP_008194869.1 919 4.9e-96 PREDICTED: GDNF-inducible zinc finger protein 1-like [Tribolium castaneum]>gi|270008503|gb|EFA04951.1| hypothetical protein TcasGA2_TC015019 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJU3 323 2.6e-28 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13912//PF16622//PF09008//PF00096//PF13465 C2H2-type zinc finger//zinc-finger C2H2-type//Head binding//Zinc finger, C2H2 type//Zinc-finger double domain GO:0009405 pathogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47170 BP_3 39.65 0.33 6154 478255651 ENN75863.1 4255 0.0e+00 hypothetical protein YQE_07592, partial [Dendroctonus ponderosae] 642935246 XM_008199707.1 724 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1589 9.1e-175 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05506//PF16656//PF00041//PF13895 Domain of unknown function (DUF756)//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0006771//GO:0016042//GO:0009395//GO:0019497 riboflavin metabolic process//lipid catabolic process//phospholipid catabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0004629//GO:0005515 acid phosphatase activity//metal ion binding//phospholipase C activity//protein binding -- -- -- -- Cluster-8309.47176 BP_3 428.48 6.15 3648 546674893 ERL86179.1 3056 0.0e+00 hypothetical protein D910_03592, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 1.08733e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1896 1.4e-210 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.47177 BP_3 84.53 1.65 2757 91090486 XP_968848.1 975 1.6e-102 PREDICTED: GTP-binding protein Di-Ras2 [Tribolium castaneum]>gi|270013863|gb|EFA10311.1| hypothetical protein TcasGA2_TC012527 [Tribolium castaneum] 642935350 XM_963755.2 98 4.14862e-41 PREDICTED: Tribolium castaneum GTP-binding protein Di-Ras2 (LOC657287), mRNA K07841 DIRAS2 DIRAS family, GTP-binding Ras-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07841 Q95KD9 747 1.8e-77 GTP-binding protein Di-Ras2 OS=Macaca fascicularis GN=DIRAS2 PE=2 SV=1 PF08477//PF03193//PF01926//PF01637//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//Archaeal ATPase//Ras family//ADP-ribosylation factor family GO:0007264//GO:0006184 small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005525//GO:0005524 GTPase activity//GTP binding//ATP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.47179 BP_3 12.00 1.00 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4718 BP_3 6.00 0.43 967 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47180 BP_3 1.00 23.78 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47183 BP_3 289.50 3.81 3951 189238946 XP_972230.2 195 6.3e-12 PREDICTED: orexin receptor type 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.47184 BP_3 591.00 11.38 2794 826469534 XP_012535839.1 912 3.2e-95 PREDICTED: uncharacterized protein LOC105836387 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47185 BP_3 92.50 1.40 3485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.47186 BP_3 554.52 7.10 4058 642931121 XP_008201670.1 421 4.0e-38 PREDICTED: autism susceptibility gene 2 protein isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04617//PF08597 Hox9 activation region//Translation initiation factor eIF3 subunit GO:0006351//GO:0006446 transcription, DNA-templated//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840//GO:0005634//GO:0005737//GO:0005852 ribosome//nucleus//cytoplasm//eukaryotic translation initiation factor 3 complex -- -- Cluster-8309.47189 BP_3 825.11 8.16 5166 642931695 XP_008196691.1 301 4.2e-24 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O55035 139 1.1e-06 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.47190 BP_3 2103.69 40.86 2773 642910843 XP_008193432.1 1665 1.5e-182 PREDICTED: xaa-Pro dipeptidase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14213 PEPD Xaa-Pro dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K14213 P12955 1250 8.4e-136 Xaa-Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 SV=3 PF05195 Aminopeptidase P, N-terminal domain -- -- GO:0030145//GO:0004177 manganese ion binding//aminopeptidase activity -- -- KOG2737 Putative metallopeptidase Cluster-8309.47195 BP_3 230.64 1.90 6157 642912869 XP_008201289.1 4842 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X6 [Tribolium castaneum] 642912868 XM_008203067.1 1425 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X6, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1296 8.6e-141 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00076//PF00781//PF00130//PF00609//PF00788//PF00628//PF07649 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase catalytic domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//Ras association (RalGDS/AF-6) domain//PHD-finger//C1-like domain GO:0007165//GO:0009395//GO:0007205//GO:0055114//GO:0035556//GO:0046486 signal transduction//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//oxidation-reduction process//intracellular signal transduction//glycerolipid metabolic process GO:0004143//GO:0005515//GO:0016301//GO:0003676//GO:0047134 diacylglycerol kinase activity//protein binding//kinase activity//nucleic acid binding//protein-disulfide reductase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.47196 BP_3 7.78 0.58 935 546680809 ERL91015.1 433 3.7e-40 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 273 5.5e-23 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2246 Galactosyltransferases Cluster-8309.47197 BP_3 182.06 1.46 6311 478257502 ENN77658.1 2180 6.7e-242 hypothetical protein YQE_05952, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SNZ0 288 6.8e-24 Girdin OS=Mus musculus GN=Ccdc88a PE=1 SV=2 PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.47198 BP_3 784.31 6.34 6250 478257502 ENN77658.1 2692 2.8e-301 hypothetical protein YQE_05952, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q13439 325 3.4e-28 Golgin subfamily A member 4 OS=Homo sapiens GN=GOLGA4 PE=1 SV=1 PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.47201 BP_3 609.19 2.55 11799 642930533 XP_008196445.1 4961 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12 [Tribolium castaneum] 642930532 XM_008198223.1 980 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X12, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 4167 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47203 BP_3 1540.97 5.26 14410 642930533 XP_008196445.1 4913 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12 [Tribolium castaneum] 642930520 XM_008198217.1 960 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X6, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 4184 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47204 BP_3 182.25 1.38 6657 642930525 XP_008196441.1 3418 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X8 [Tribolium castaneum] 795051011 XM_012014668.1 258 1.14918e-129 PREDICTED: Vollenhovia emeryi inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC105563237), transcript variant X22, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 1840 7.8e-204 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47207 BP_3 201.56 0.69 14429 642930521 XP_008196439.1 3729 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X6 [Tribolium castaneum] 642930520 XM_008198217.1 806 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X6, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 3317 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47209 BP_3 828.83 5.96 7000 642930523 XP_008196440.1 2319 5.7e-258 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X7 [Tribolium castaneum] 795051011 XM_012014668.1 258 1.20872e-129 PREDICTED: Vollenhovia emeryi inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC105563237), transcript variant X22, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 1837 1.8e-203 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328//PF17076 Histidine phosphatase superfamily (branch 2)//SBE2, cell-qall formation GO:0006771//GO:0019497//GO:0031505 riboflavin metabolic process//hexachlorocyclohexane metabolic process//fungal-type cell wall organization GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.4721 BP_3 10.47 0.41 1525 332373478 AEE61880.1 464 1.6e-43 unknown [Dendroctonus ponderosae]>gi|478263741|gb|ENN82044.1| hypothetical protein YQE_01619, partial [Dendroctonus ponderosae]>gi|546670972|gb|ERL83504.1| hypothetical protein D910_00535 [Dendroctonus ponderosae]>gi|546679616|gb|ERL90053.1| hypothetical protein D910_07409 [Dendroctonus ponderosae] -- -- -- -- -- K00949 thiN, TPK1, THI80 thiamine pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00949 Q9H3S4 308 7.9e-27 Thiamin pyrophosphokinase 1 OS=Homo sapiens GN=TPK1 PE=1 SV=1 PF04263//PF01341//PF04265 Thiamin pyrophosphokinase, catalytic domain//Glycosyl hydrolases family 6//Thiamin pyrophosphokinase, vitamin B1 binding domain GO:0005975//GO:0030245//GO:0006772//GO:0009229 carbohydrate metabolic process//cellulose catabolic process//thiamine metabolic process//thiamine diphosphate biosynthetic process GO:0004788//GO:0030975//GO:0004553//GO:0005524 thiamine diphosphokinase activity//thiamine binding//hydrolase activity, hydrolyzing O-glycosyl compounds//ATP binding -- -- KOG3153 Thiamine pyrophosphokinase Cluster-8309.47210 BP_3 234.26 1.76 6699 642930525 XP_008196441.1 3404 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X8 [Tribolium castaneum] 795051011 XM_012014668.1 258 1.15647e-129 PREDICTED: Vollenhovia emeryi inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC105563237), transcript variant X22, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 1841 6.0e-204 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47211 BP_3 64.52 3.59 1157 91089445 XP_966341.1 348 3.3e-30 PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|91089447|ref|XP_975797.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|270012573|gb|EFA09021.1| hypothetical protein TcasGA2_TC006730 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 P52565 234 2.3e-18 Rho GDP-dissociation inhibitor 1 OS=Homo sapiens GN=ARHGDIA PE=1 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.47214 BP_3 74.14 0.68 5541 642940052 XP_008200969.1 2913 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 1.8e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF07724//PF00004//PF00439//PF05496//PF06068//PF01695//PF07728//PF00910//PF04851//PF00005 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Bromodomain//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//RNA helicase//Type III restriction enzyme, res subunit//ABC transporter GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0003724//GO:0009378//GO:0016887//GO:0005515//GO:0003723//GO:0003678//GO:0005524//GO:0003677//GO:0016787 RNA helicase activity//four-way junction helicase activity//ATPase activity//protein binding//RNA binding//DNA helicase activity//ATP binding//DNA binding//hydrolase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.47215 BP_3 20.44 0.36 3020 642915313 XP_008190567.1 1625 7.3e-178 PREDICTED: dosage compensation regulator isoform X1 [Tribolium castaneum] 766920220 XM_011506269.1 107 4.51753e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1210 4.0e-131 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF00437//PF00270//PF03060//PF03368 Type II/IV secretion system protein//DEAD/DEAH box helicase//Nitronate monooxygenase//Dicer dimerisation domain GO:0006810//GO:0051252//GO:0055114//GO:0006807 transport//regulation of RNA metabolic process//oxidation-reduction process//nitrogen compound metabolic process GO:0018580//GO:0005524//GO:0016891//GO:0003676 nitronate monooxygenase activity//ATP binding//endoribonuclease activity, producing 5'-phosphomonoesters//nucleic acid binding -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.47216 BP_3 419.62 7.58 2961 642915313 XP_008190567.1 1620 2.7e-177 PREDICTED: dosage compensation regulator isoform X1 [Tribolium castaneum] 766920220 XM_011506269.1 107 4.42821e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1205 1.5e-130 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF03060//PF00270//PF00437//PF03368 Nitronate monooxygenase//DEAD/DEAH box helicase//Type II/IV secretion system protein//Dicer dimerisation domain GO:0006810//GO:0051252//GO:0006807//GO:0055114 transport//regulation of RNA metabolic process//nitrogen compound metabolic process//oxidation-reduction process GO:0005524//GO:0018580//GO:0003676//GO:0016891 ATP binding//nitronate monooxygenase activity//nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.47218 BP_3 662.89 8.57 4019 642923221 XP_008193661.1 1362 3.0e-147 PREDICTED: uncharacterized protein LOC103313092 [Tribolium castaneum] -- -- -- -- -- K18269 PDCD10 programmed cell death protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18269 Q8AVR4 477 5.2e-46 Programmed cell death protein 10 OS=Xenopus laevis GN=pdcd10 PE=2 SV=1 PF00669//PF00863//PF09815 Bacterial flagellin N-terminal helical region//Peptidase family C4//XK-related protein GO:0006508//GO:0071973 proteolysis//bacterial-type flagellum-dependent cell motility GO:0008234//GO:0005198 cysteine-type peptidase activity//structural molecule activity GO:0016021 integral component of membrane KOG4025 Putative apoptosis related protein Cluster-8309.47219 BP_3 33.21 0.44 3965 642923221 XP_008193661.1 1362 3.0e-147 PREDICTED: uncharacterized protein LOC103313092 [Tribolium castaneum] -- -- -- -- -- K18269 PDCD10 programmed cell death protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18269 Q8AVR4 477 5.2e-46 Programmed cell death protein 10 OS=Xenopus laevis GN=pdcd10 PE=2 SV=1 PF09815//PF00669//PF00863 XK-related protein//Bacterial flagellin N-terminal helical region//Peptidase family C4 GO:0071973//GO:0006508 bacterial-type flagellum-dependent cell motility//proteolysis GO:0005198//GO:0008234 structural molecule activity//cysteine-type peptidase activity GO:0016021 integral component of membrane KOG4025 Putative apoptosis related protein Cluster-8309.4722 BP_3 2.00 0.60 453 807040371 XP_012161059.1 157 1.8e-08 PREDICTED: disks large 1 tumor suppressor protein isoform X6 [Ceratitis capitata] -- -- -- -- -- K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 157 7.6e-10 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47220 BP_3 66.22 0.48 6953 91077500 XP_969314.1 3473 0.0e+00 PREDICTED: exocyst complex component 1 [Tribolium castaneum]>gi|270002145|gb|EEZ98592.1| hypothetical protein TcasGA2_TC001107 [Tribolium castaneum] 805812953 XM_012292417.1 89 1.06161e-35 PREDICTED: Megachile rotundata exocyst complex component 1 (LOC100878684), transcript variant X4, mRNA -- -- -- -- Q9VVG4 2093 3.7e-233 Exocyst complex component 1 OS=Drosophila melanogaster GN=sec3 PE=1 SV=2 PF00588//PF07544 SpoU rRNA Methylase family//RNA polymerase II transcription mediator complex subunit 9 GO:0006396//GO:0009451//GO:0006357 RNA processing//RNA modification//regulation of transcription from RNA polymerase II promoter GO:0008173//GO:0001104//GO:0003723 RNA methyltransferase activity//RNA polymerase II transcription cofactor activity//RNA binding GO:0016592 mediator complex KOG2148 Exocyst protein Sec3 Cluster-8309.47221 BP_3 165.44 1.69 5013 91091902 XP_971322.1 679 6.0e-68 PREDICTED: mediator of RNA polymerase II transcription subunit 22 [Tribolium castaneum]>gi|270000800|gb|EEZ97247.1| hypothetical protein TcasGA2_TC011045 [Tribolium castaneum] -- -- -- -- -- K15139 MED22 mediator of RNA polymerase II transcription subunit 22 http://www.genome.jp/dbget-bin/www_bget?ko:K15139 Q7QB45 538 5.5e-53 Mediator of RNA polymerase II transcription subunit 22 OS=Anopheles gambiae GN=MED22 PE=3 SV=3 PF00219//PF06179//PF14528 Insulin-like growth factor binding protein//Surfeit locus protein 5 subunit 22 of Mediator complex//LAGLIDADG-like domain GO:0006357//GO:0001558 regulation of transcription from RNA polymerase II promoter//regulation of cell growth GO:0005520//GO:0004519//GO:0001104 insulin-like growth factor binding//endonuclease activity//RNA polymerase II transcription cofactor activity GO:0005576//GO:0016592//GO:0016942 extracellular region//mediator complex//insulin-like growth factor binding protein complex KOG3304 Surfeit family protein 5 Cluster-8309.47222 BP_3 43.62 0.84 2790 270006157 EFA02605.1 2133 8.4e-237 hypothetical protein TcasGA2_TC008324 [Tribolium castaneum] 332375782 BT128071.1 218 8.23202e-108 Dendroctonus ponderosae clone DPO116_B20 unknown mRNA K01892 HARS, hisS histidyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01892 Q61035 1637 1.1e-180 Histidine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Hars PE=2 SV=2 PF00458//PF00587//PF00152 WHEP-TRS domain//tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG1936 Histidyl-tRNA synthetase Cluster-8309.47223 BP_3 1279.71 11.28 5758 270012867 EFA09315.1 1048 1.1e-110 hypothetical protein TcasGA2_TC030748 [Tribolium castaneum] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 532 3.2e-52 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 PF08288//PF07830//PF04420 PIGA (GPI anchor biosynthesis)//Protein serine/threonine phosphatase 2C, C-terminal domain//CHD5-like protein GO:0006470//GO:0006506//GO:0071816 protein dephosphorylation//GPI anchor biosynthetic process//tail-anchored membrane protein insertion into ER membrane GO:0000287//GO:0004721//GO:0030145 magnesium ion binding//phosphoprotein phosphatase activity//manganese ion binding -- -- KOG2687 Spindle pole body protein, contains UNC-84 domain Cluster-8309.47224 BP_3 67.80 0.65 5340 91089655 XP_974084.1 2180 5.7e-242 PREDICTED: protein wntless [Tribolium castaneum]>gi|270011339|gb|EFA07787.1| hypothetical protein TcasGA2_TC005345 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4LC58 1542 2.2e-169 Protein wntless OS=Drosophila virilis GN=wls PE=3 SV=1 PF00651 BTB/POZ domain GO:0016055 Wnt signaling pathway GO:0005515//GO:0017147 protein binding//Wnt-protein binding -- -- -- -- Cluster-8309.47225 BP_3 52.69 3.62 993 642933508 XP_008197447.1 406 5.4e-37 PREDICTED: speckle-type POZ protein-like A isoform X4 [Tribolium castaneum]>gi|642933510|ref|XP_008197448.1| PREDICTED: speckle-type POZ protein-like A isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47226 BP_3 5.69 0.45 898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47227 BP_3 713.31 53.70 932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47228 BP_3 11.26 0.63 1155 195341822 XP_002037504.1 634 2.3e-63 GM18300 [Drosophila sechellia]>gi|194132354|gb|EDW53922.1| GM18300 [Drosophila sechellia] 731200838 XM_010617131.1 98 1.71022e-41 PREDICTED: Fukomys damarensis 1-acylglycerol-3-phosphate O-acyltransferase 6 (Agpat6), mRNA K13506 GPAT3_4, AGPAT9, AGPAT6 glycerol-3-phosphate O-acyltransferase 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13506 Q6DG38 525 4.1e-52 Glycerol-3-phosphate acyltransferase 3 OS=Danio rerio GN=agpat9 PE=2 SV=1 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.47229 BP_3 17.00 1.83 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4723 BP_3 34.00 0.85 2223 270012476 EFA08924.1 193 6.0e-12 hypothetical protein TcasGA2_TC006631 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47231 BP_3 268.36 7.65 1982 91080597 XP_973963.1 1525 1.9e-166 PREDICTED: vacuolar protein-sorting-associated protein 36 [Tribolium castaneum]>gi|270005813|gb|EFA02261.1| hypothetical protein TcasGA2_TC007925 [Tribolium castaneum] -- -- -- -- -- K12190 VPS36, EAP45 ESCRT-II complex subunit VPS36 http://www.genome.jp/dbget-bin/www_bget?ko:K12190 Q9VU87 1000 5.9e-107 Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0032266//GO:0043130 phosphatidylinositol-3-phosphate binding//ubiquitin binding -- -- KOG2760 Vacuolar sorting protein VPS36 Cluster-8309.47234 BP_3 508.90 6.72 3942 91083301 XP_974629.1 1378 4.2e-149 PREDICTED: alpha-methylacyl-CoA racemase [Tribolium castaneum]>gi|270007738|gb|EFA04186.1| hypothetical protein TcasGA2_TC014435 [Tribolium castaneum] -- -- -- -- -- K01796 E5.1.99.4, AMACR, mcr alpha-methylacyl-CoA racemase http://www.genome.jp/dbget-bin/www_bget?ko:K01796 O09174 1099 3.9e-118 Alpha-methylacyl-CoA racemase OS=Mus musculus GN=Amacr PE=1 SV=4 PF02515//PF04178//PF07647//PF00536 CoA-transferase family III//Got1/Sft2-like family//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0008152//GO:0016192 metabolic process//vesicle-mediated transport GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.47235 BP_3 122.00 4.01 1757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47238 BP_3 151.32 3.07 2664 91080563 XP_973259.1 2637 2.9e-295 PREDICTED: alpha-N-acetylglucosaminidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 1665 6.1e-184 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.47239 BP_3 55.80 0.66 4349 91093228 XP_967462.1 705 5.0e-71 PREDICTED: phosphopantothenoylcysteine decarboxylase [Tribolium castaneum]>gi|270016594|gb|EFA13040.1| hypothetical protein TcasGA2_TC010571 [Tribolium castaneum] -- -- -- -- -- K01598 PPCDC, coaC phosphopantothenoylcysteine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01598 Q8BZB2 574 3.2e-57 Phosphopantothenoylcysteine decarboxylase OS=Mus musculus GN=Ppcdc PE=2 SV=1 PF02297//PF08070//PF02569//PF05676//PF02441 Cytochrome oxidase c subunit VIb//DTHCT (NUC029) region//Pantoate-beta-alanine ligase//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Flavoprotein GO:0008152//GO:0006744//GO:0006123//GO:0006120//GO:0015940//GO:0006118//GO:0006814//GO:0015992//GO:0019482//GO:0006265 metabolic process//ubiquinone biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//mitochondrial electron transport, NADH to ubiquinone//pantothenate biosynthetic process//obsolete electron transport//sodium ion transport//proton transport//beta-alanine metabolic process//DNA topological change GO:0003824//GO:0003677//GO:0003954//GO:0003918//GO:0004592//GO:0004129//GO:0005524//GO:0008137 catalytic activity//DNA binding//NADH dehydrogenase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity//pantoate-beta-alanine ligase activity//cytochrome-c oxidase activity//ATP binding//NADH dehydrogenase (ubiquinone) activity GO:0005634//GO:0045277//GO:0005739 nucleus//respiratory chain complex IV//mitochondrion KOG0672 Halotolerance protein HAL3 (contains flavoprotein domain) Cluster-8309.47241 BP_3 4.00 17.19 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47242 BP_3 506.20 6.93 3811 642934319 XP_008198599.1 1520 1.4e-165 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] 831504568 XM_012856442.1 55 4.60957e-17 PREDICTED: Fundulus heteroclitus inositol hexakisphosphate kinase 1 (ip6k1), mRNA K07756 IP6K, IHPK inositol-hexakisphosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07756 Q96PC2 434 4.8e-41 Inositol hexakisphosphate kinase 3 OS=Homo sapiens GN=IP6K3 PE=1 SV=2 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1620 Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex Cluster-8309.47244 BP_3 238.32 10.68 1367 642934319 XP_008198599.1 370 1.1e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47245 BP_3 198.53 4.00 2685 189240781 XP_969579.2 1527 1.5e-166 PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum]>gi|642934322|ref|XP_008198600.1| PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum] 831504568 XM_012856442.1 55 3.23463e-17 PREDICTED: Fundulus heteroclitus inositol hexakisphosphate kinase 1 (ip6k1), mRNA K07756 IP6K, IHPK inositol-hexakisphosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07756 Q96PC2 434 3.4e-41 Inositol hexakisphosphate kinase 3 OS=Homo sapiens GN=IP6K3 PE=1 SV=2 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1620 Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex Cluster-8309.47247 BP_3 32.00 1.48 1335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47249 BP_3 137.32 2.35 3108 642932487 XP_008197135.1 1919 6.1e-212 PREDICTED: E3 ubiquitin-protein ligase RBBP6 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 4.6e-82 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF00097//PF00098//PF04564//PF14634//PF13639//PF08783 Zinc finger, C3HC4 type (RING finger)//Zinc knuckle//U-box domain//zinc-RING finger domain//Ring finger domain//DWNN domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270//GO:0003676 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0314 Predicted E3 ubiquitin ligase Cluster-8309.47257 BP_3 413.65 3.67 5717 478262859 ENN81341.1 1820 3.4e-200 hypothetical protein YQE_02252, partial [Dendroctonus ponderosae] 213513283 NM_001141934.1 389 0 Tribolium castaneum estrogen-related receptor (Err), mRNA K08703 NR3BN, ERR estrogen-related receptor ERR http://www.genome.jp/dbget-bin/www_bget?ko:K08703 O95718 803 1.2e-83 Steroid hormone receptor ERR2 OS=Homo sapiens GN=ESRRB PE=1 SV=2 PF00106//PF00104//PF01370//PF00105//PF00324 short chain dehydrogenase//Ligand-binding domain of nuclear hormone receptor//NAD dependent epimerase/dehydratase family//Zinc finger, C4 type (two domains)//Amino acid permease GO:0006810//GO:0055085//GO:0008152//GO:0006355//GO:0043401 transport//transmembrane transport//metabolic process//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0016491//GO:0003824//GO:0050662//GO:0003700//GO:0008270//GO:0043565 oxidoreductase activity//catalytic activity//coenzyme binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0016020 transcription factor complex//nucleus//membrane -- -- Cluster-8309.47260 BP_3 209.72 3.07 3584 189234531 XP_967948.2 892 8.6e-93 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 704 2.2e-72 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF13520//PF00324//PF03522 Amino acid permease//Amino acid permease//Solute carrier family 12 GO:0003333//GO:0006811//GO:0006865//GO:0055085//GO:0006810 amino acid transmembrane transport//ion transport//amino acid transport//transmembrane transport//transport GO:0015171//GO:0005215 amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.47261 BP_3 787.00 12.67 3286 546673947 ERL85458.1 3578 0.0e+00 hypothetical protein D910_02877 [Dendroctonus ponderosae] 657572521 XM_008291658.1 272 9.31089e-138 PREDICTED: Stegastes partitus ribonucleoside-diphosphate reductase large subunit (LOC103364515), mRNA K10807 RRM1 ribonucleoside-diphosphate reductase subunit M1 http://www.genome.jp/dbget-bin/www_bget?ko:K10807 P07742 3192 0.0e+00 Ribonucleoside-diphosphate reductase large subunit OS=Mus musculus GN=Rrm1 PE=1 SV=2 PF02867//PF00317 Ribonucleotide reductase, barrel domain//Ribonucleotide reductase, all-alpha domain GO:0009186//GO:0006144//GO:0006260//GO:0006206//GO:0055114 deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process//DNA replication//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0005524//GO:0004748 ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0005971 ribonucleoside-diphosphate reductase complex KOG1112 Ribonucleotide reductase, alpha subunit Cluster-8309.47275 BP_3 116.00 3.65 1825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47279 BP_3 51.35 0.54 4858 642918982 XP_008191684.1 2908 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.51453e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 1992 1.3e-221 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122//PF05109 E1-E2 ATPase//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058 viral life cycle GO:0000166//GO:0046872 nucleotide binding//metal ion binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.47280 BP_3 225.00 12.10 1188 195429517 XP_002062805.1 222 1.4e-15 GK19503 [Drosophila willistoni]>gi|194158890|gb|EDW73791.1| GK19503 [Drosophila willistoni] -- -- -- -- -- -- -- -- -- Q54VM3 170 6.1e-11 TBC1 domain family member 5 homolog A OS=Dictyostelium discoideum GN=tbc1d5A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47281 BP_3 19.92 0.31 3385 270008310 EFA04758.1 3290 0.0e+00 hypothetical protein TcasGA2_TC030607 [Tribolium castaneum] 642924172 XM_965504.3 284 2.04767e-144 PREDICTED: Tribolium castaneum protein shuttle craft (LOC659177), mRNA K12236 NFX1 transcriptional repressor NF-X1 http://www.genome.jp/dbget-bin/www_bget?ko:K12236 P40798 2285 9.9e-256 Protein shuttle craft OS=Drosophila melanogaster GN=stc PE=1 SV=2 PF01422//PF01424 NF-X1 type zinc finger//R3H domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003676//GO:0008270 transcription factor activity, sequence-specific DNA binding//nucleic acid binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.47282 BP_3 1148.79 24.67 2536 189237698 XP_970597.2 3338 0.0e+00 PREDICTED: protein shuttle craft [Tribolium castaneum] 642924172 XM_965504.3 284 1.52966e-144 PREDICTED: Tribolium castaneum protein shuttle craft (LOC659177), mRNA K12236 NFX1 transcriptional repressor NF-X1 http://www.genome.jp/dbget-bin/www_bget?ko:K12236 P40798 2285 7.4e-256 Protein shuttle craft OS=Drosophila melanogaster GN=stc PE=1 SV=2 PF01422//PF01424 NF-X1 type zinc finger//R3H domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0003676 transcription factor activity, sequence-specific DNA binding//zinc ion binding//nucleic acid binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.47284 BP_3 669.22 16.83 2208 91090216 XP_968004.1 1600 4.2e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.5e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008146//GO:0008476 sulfotransferase activity//protein-tyrosine sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.47285 BP_3 598.23 7.37 4203 642921416 XP_008192857.1 2259 3.1e-251 PREDICTED: transmembrane protein 62 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P6H9 1134 3.6e-122 Transmembrane protein 62 OS=Homo sapiens GN=TMEM62 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47287 BP_3 783.00 6.11 6465 91079166 XP_967495.1 4861 0.0e+00 PREDICTED: HEAT repeat-containing protein 1 homolog [Tribolium castaneum]>gi|270003615|gb|EFA00063.1| hypothetical protein TcasGA2_TC002876 [Tribolium castaneum] -- -- -- -- -- K14550 UTP10, HEATR1 U3 small nucleolar RNA-associated protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14550 Q7SY48 1495 7.6e-164 HEAT repeat-containing protein 1 OS=Danio rerio GN=heatr1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1837 Uncharacterized conserved protein Cluster-8309.47289 BP_3 190.79 5.17 2069 546686183 ERL95563.1 873 7.9e-91 hypothetical protein D910_12824, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9JTS5 218 2.9e-16 Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Xenopus tropicalis GN=tut1 PE=2 SV=1 PF09249 tRNA nucleotidyltransferase, second domain GO:0008033 tRNA processing GO:0016437//GO:0004810 tRNA cytidylyltransferase activity//tRNA adenylyltransferase activity -- -- KOG2277 S-M checkpoint control protein CID1 and related nucleotidyltransferases Cluster-8309.47290 BP_3 57.33 2.03 1655 642915071 XP_008190398.1 1740 1.8e-191 PREDICTED: protein groucho isoform X4 [Tribolium castaneum] 602715430 XM_007467859.1 365 0 PREDICTED: Lipotes vexillifer transducin-like enhancer of split 3 (TLE3), transcript variant X12, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 1685 1.8e-186 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.47293 BP_3 616.18 8.55 3767 270014679 EFA11127.1 650 1.0e-64 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 256 2.1e-20 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47295 BP_3 33.79 0.33 5222 91080947 XP_974375.1 1989 7.8e-220 PREDICTED: protein arginine N-methyltransferase 1 [Tribolium castaneum]>gi|270005950|gb|EFA02398.1| hypothetical protein TcasGA2_TC008078 [Tribolium castaneum] -- -- -- -- -- K11436 PRMT3 protein arginine N-methyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11436 O60678 1062 1.0e-113 Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 PE=1 SV=3 PF01340//PF03602//PF05185//PF01209//PF08241//PF02390//PF01728//PF01135//PF05175//PF00517//PF02140 Met Apo-repressor, MetJ//Conserved hypothetical protein 95//PRMT5 arginine-N-methyltransferase//ubiE/COQ5 methyltransferase family//Methyltransferase domain//Putative methyltransferase//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Retroviral envelope protein//Galactose binding lectin domain GO:0006555//GO:0046500//GO:0032259//GO:0006400//GO:0009451//GO:0006479//GO:0008152//GO:0008033//GO:0006355//GO:0031167//GO:0006464 methionine metabolic process//S-adenosylmethionine metabolic process//methylation//tRNA modification//RNA modification//protein methylation//metabolic process//tRNA processing//regulation of transcription, DNA-templated//rRNA methylation//cellular protein modification process GO:0004719//GO:0008176//GO:0003700//GO:0030246//GO:0008168//GO:0005198 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//transcription factor activity, sequence-specific DNA binding//carbohydrate binding//methyltransferase activity//structural molecule activity GO:0019031//GO:0005667 viral envelope//transcription factor complex KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.47296 BP_3 18.00 0.78 1400 642915536 XP_008190656.1 409 3.4e-37 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] 571572836 XM_006565668.1 108 5.74744e-47 PREDICTED: Apis mellifera uncharacterized FAM18-like protein CG5021-like (LOC408503), transcript variant X6, mRNA -- -- -- -- Q8IQC1 373 2.1e-34 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.47299 BP_3 194.68 1.58 6234 642936172 XP_008198327.1 2217 3.4e-246 PREDICTED: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [Tribolium castaneum]>gi|270014057|gb|EFA10505.1| hypothetical protein TcasGA2_TC012753 [Tribolium castaneum] -- -- -- -- -- K12489 ACAP Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12489 Q6IVG4 1156 1.5e-124 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Oryctolagus cuniculus GN=ACAP2 PE=2 SV=1 PF05130//PF01412//PF03114//PF13606//PF02170//PF00023 FlgN protein//Putative GTPase activating protein for Arf//BAR domain//Ankyrin repeat//PAZ domain//Ankyrin repeat GO:0044780 bacterial-type flagellum assembly GO:0005515//GO:0005488//GO:0005096 protein binding//binding//GTPase activator activity GO:0005737 cytoplasm KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.473 BP_3 12.00 2.40 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47302 BP_3 193.38 2.66 3795 270002245 EEZ98692.1 1521 1.1e-165 hypothetical protein TcasGA2_TC001228 [Tribolium castaneum] -- -- -- -- -- K08187 SLC16A10 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K08187 Q91Y77 935 3.9e-99 Monocarboxylate transporter 10 OS=Rattus norvegicus GN=Slc16a10 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.47305 BP_3 457.00 5.66 4185 91094681 XP_967379.1 2293 3.5e-255 PREDICTED: beta-catenin-like protein 1 [Tribolium castaneum]>gi|270016504|gb|EFA12950.1| hypothetical protein TcasGA2_TC005070 [Tribolium castaneum] -- -- -- -- -- K12864 CTNNBL1 beta-catenin-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12864 Q8WYA6 1509 1.2e-165 Beta-catenin-like protein 1 OS=Homo sapiens GN=CTNNBL1 PE=1 SV=1 PF02985//PF02892//PF00782//PF00102//PF00514//PF11648//PF00096 HEAT repeat//BED zinc finger//Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Armadillo/beta-catenin-like repeat//C-terminal domain of RIG-I//Zinc finger, C2H2 type GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0005515//GO:0004725//GO:0003677//GO:0046872//GO:0016817 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//DNA binding//metal ion binding//hydrolase activity, acting on acid anhydrides -- -- KOG2734 Uncharacterized conserved protein Cluster-8309.47307 BP_3 43.17 0.51 4334 478263754 ENN82050.1 936 8.2e-98 hypothetical protein YQE_01563, partial [Dendroctonus ponderosae] -- -- -- -- -- K17083 FERMT2, KIND2 kindlin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17083 Q9VZI3 598 5.3e-60 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.47308 BP_3 184.00 1.92 4899 270005111 EFA01559.1 1885 8.4e-208 hypothetical protein TcasGA2_TC007120 [Tribolium castaneum] 642921112 XM_008194472.1 648 0 PREDICTED: Tribolium castaneum B-cell lymphoma/leukemia 11B (LOC664174), mRNA -- -- -- -- Q9NSJ1 214 2.0e-15 Putative zinc finger protein 355P OS=Homo sapiens GN=ZNF355P PE=5 SV=2 PF13912//PF07776//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.4731 BP_3 10.00 0.60 1095 270008839 EFA05287.1 261 3.9e-20 hypothetical protein TcasGA2_TC015444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GQU6 149 1.5e-08 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 OS=Mus musculus GN=Lingo3 PE=2 SV=2 PF00560//PF13855//PF14955 Leucine Rich Repeat//Leucine rich repeat//Mitochondrial ribosome subunit S24 -- -- GO:0005515 protein binding GO:0005739 mitochondrion KOG0619 FOG: Leucine rich repeat Cluster-8309.47312 BP_3 33.18 0.38 4500 642931475 XP_008196599.1 1698 3.7e-186 PREDICTED: insulin receptor substrate 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 P84770 503 5.7e-49 Insulin receptor substrate 1-B OS=Xenopus laevis GN=irs1-b PE=2 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.47315 BP_3 1902.38 12.81 7452 270011103 EFA07551.1 3565 0.0e+00 semaphorin-1a-like protein [Tribolium castaneum] 642930289 XM_008198109.1 776 0 PREDICTED: Tribolium castaneum semaphorin-1A (LOC660780), transcript variant X2, mRNA K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q24322 2582 7.9e-290 Semaphorin-1A OS=Drosophila melanogaster GN=Sema-1a PE=2 SV=2 PF01437//PF01403//PF05700 Plexin repeat//Sema domain//Breast carcinoma amplified sequence 2 (BCAS2) GO:0006397 mRNA processing GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.47317 BP_3 1823.80 9.11 9937 197276678 NP_001127849.1 4725 0.0e+00 patched [Tribolium castaneum]>gi|270015128|gb|EFA11576.1| patched [Tribolium castaneum] 197276677 NM_001134377.1 723 0 Tribolium castaneum patched (Ptc), mRNA K15013 ACSBG long-chain-fatty-acid--CoA ligase ACSBG http://www.genome.jp/dbget-bin/www_bget?ko:K15013 P18502 2167 1.4e-241 Protein patched OS=Drosophila melanogaster GN=ptc PE=2 SV=2 PF02116//PF00501//PF08941//PF16499//PF03572//PF02460 Fungal pheromone mating factor STE2 GPCR//AMP-binding enzyme//USP8 interacting//Alpha galactosidase A//Peptidase family S41//Patched family GO:0007165//GO:0007606//GO:0005975//GO:0007186//GO:0016567//GO:0008152//GO:0019236//GO:0006508 signal transduction//sensory perception of chemical stimulus//carbohydrate metabolic process//G-protein coupled receptor signaling pathway//protein ubiquitination//metabolic process//response to pheromone//proteolysis GO:0008158//GO:0031386//GO:0004553//GO:0008236//GO:0004932//GO:0016881//GO:0003824 hedgehog receptor activity//protein tag//hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type peptidase activity//mating-type factor pheromone receptor activity//acid-amino acid ligase activity//catalytic activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1935 Membrane protein Patched/PTCH Cluster-8309.47318 BP_3 105.50 1.22 4472 642937652 XP_966876.3 827 3.7e-85 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6B4Z5 368 2.5e-33 Zinc finger Y-chromosomal protein OS=Pan troglodytes GN=ZFY PE=2 SV=1 PF00096//PF13465//PF07649//PF02738 Zinc finger, C2H2 type//Zinc-finger double domain//C1-like domain//Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0047134//GO:0046872 oxidoreductase activity//protein-disulfide reductase activity//metal ion binding -- -- -- -- Cluster-8309.4732 BP_3 9.00 0.70 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47320 BP_3 31.63 2.52 897 478253168 ENN73539.1 316 1.3e-26 hypothetical protein YQE_09790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q867Z4 288 9.6e-25 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01428//PF02892//PF01155//PF00096//PF13465 AN1-like Zinc finger//BED zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006464 cellular protein modification process GO:0008270//GO:0003677//GO:0016151//GO:0046872 zinc ion binding//DNA binding//nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.47325 BP_3 85.24 0.82 5315 847111375 XP_012814894.1 858 1.1e-88 PREDICTED: uncharacterized protein LOC105946753 [Xenopus (Silurana) tropicalis]>gi|847149816|ref|XP_012822809.1| PREDICTED: uncharacterized protein LOC105947875 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.47327 BP_3 413.53 4.25 4985 91089275 XP_970398.1 2665 3.1e-298 PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase 9 isoform X1 [Tribolium castaneum] 642933027 XM_965305.2 493 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 2186 4.4e-244 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.47329 BP_3 10.35 0.92 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47330 BP_3 56.46 1.09 2794 642925558 XP_008194598.1 1188 3.2e-127 PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925560|ref|XP_008194599.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925562|ref|XP_008194600.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|270008677|gb|EFA05125.1| hypothetical protein TcasGA2_TC015240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6Q4G4 327 9.0e-29 Angiotensin-converting enzyme OS=Theromyzon tessulatum GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.47334 BP_3 5.00 0.63 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47336 BP_3 35.88 0.32 5641 642929205 XP_008195735.1 3215 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 91 6.65318e-37 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q9Y4E6 1355 1.1e-147 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF01506//PF00784//PF00400 Hepatitis C virus non-structural 5a protein membrane anchor//MyTH4 domain//WD domain, G-beta repeat GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0005515//GO:0004197//GO:0004252//GO:0017111//GO:0003968 protein binding//cysteine-type endopeptidase activity//serine-type endopeptidase activity//nucleoside-triphosphatase activity//RNA-directed RNA polymerase activity GO:0005856//GO:0031379 cytoskeleton//RNA-directed RNA polymerase complex KOG4155 FOG: WD40 repeat Cluster-8309.47339 BP_3 264.26 5.09 2796 642913398 XP_008200993.1 1367 5.6e-148 PREDICTED: fruitless isoform X3 [Tribolium castaneum] 642913407 XM_008202776.1 250 1.34199e-125 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X7, mRNA -- -- -- -- Q8IN81 552 7.3e-55 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00096//PF00651 Zinc finger, C2H2 type//BTB/POZ domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.47341 BP_3 489.45 12.44 2188 189234531 XP_967948.2 1727 7.9e-190 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 1438 1.1e-157 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006811//GO:0006810//GO:0055085 ion transport//transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.47344 BP_3 27.43 1.36 1261 91089745 XP_975162.1 578 7.8e-57 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 439 4.2e-42 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF07714//PF06293 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.47345 BP_3 1.00 0.88 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47346 BP_3 39.00 1.62 1452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47348 BP_3 10.31 0.74 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47349 BP_3 57.00 8.97 598 91089745 XP_975162.1 277 2.9e-22 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 Q1RMT7 222 2.9e-17 Serine/threonine-protein kinase RIO3 OS=Bos taurus GN=RIOK3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.4735 BP_3 32.51 0.84 2167 759162834 XP_011373103.1 547 5.2e-53 PREDICTED: uncharacterized protein LOC105301931 [Pteropus vampyrus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9Y6Q3 534 6.9e-53 Zinc finger protein 37 homolog OS=Homo sapiens GN=ZFP37 PE=2 SV=3 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47350 BP_3 187.58 6.27 1734 91089745 XP_975162.1 687 2.4e-69 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 404 6.6e-38 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.47351 BP_3 2.00 2.09 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47352 BP_3 20.10 0.58 1956 91089745 XP_975162.1 695 3.3e-70 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 412 8.8e-39 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.47353 BP_3 20.23 1.19 1111 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47356 BP_3 8.50 0.49 1120 270007459 EFA03907.1 401 2.3e-36 hypothetical protein TcasGA2_TC014039 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 205 5.1e-15 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47357 BP_3 14.89 0.85 1135 91078972 XP_974414.1 492 6.6e-47 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05187 220 9.4e-17 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868 Transglutaminase family GO:0018149 peptide cross-linking -- -- -- -- -- -- Cluster-8309.47360 BP_3 1.00 1.40 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47367 BP_3 25.05 0.58 2379 642921234 XP_008192774.1 1587 1.5e-173 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X3 [Tribolium castaneum] 642921233 XM_008194552.1 277 1.11614e-140 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X6, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q62415 386 1.1e-35 Apoptosis-stimulating of p53 protein 1 OS=Mus musculus GN=Ppp1r13b PE=2 SV=2 PF05188 MutS domain II GO:0006298 mismatch repair GO:0030983//GO:0005524 mismatched DNA binding//ATP binding -- -- -- -- Cluster-8309.47368 BP_3 712.00 27.65 1533 91086281 XP_973404.1 1589 5.5e-174 PREDICTED: alpha-N-acetylgalactosaminidase-like [Tribolium castaneum] -- -- -- -- -- K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 1151 1.4e-124 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF16499//PF02065 Alpha galactosidase A//Melibiase GO:0001575//GO:0046486//GO:0005975//GO:0006012 globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process//galactose metabolic process GO:0004557//GO:0004553 alpha-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.47369 BP_3 89.80 0.88 5214 768954657 XP_011616057.1 422 3.9e-38 PREDICTED: zinc finger protein 595-like [Takifugu rubripes] -- -- -- -- -- -- -- -- -- E9QAG8 390 8.3e-36 Zinc finger protein 431 OS=Mus musculus GN=Znf431 PE=1 SV=1 PF13465//PF16622//PF05485//PF13912//PF02892//PF00096//PF06467//PF07776//PF17123 Zinc-finger double domain//zinc-finger C2H2-type//THAP domain//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//RING-like zinc finger -- -- GO:0003676//GO:0003677//GO:0008270//GO:0005515//GO:0046872 nucleic acid binding//DNA binding//zinc ion binding//protein binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.4737 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47371 BP_3 139.58 4.08 1942 91079056 XP_975139.1 1149 7.4e-123 PREDICTED: uncharacterized protein LOC664025 [Tribolium castaneum]>gi|270004195|gb|EFA00643.1| hypothetical protein TcasGA2_TC003519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47373 BP_3 575.69 19.61 1707 91079696 XP_968351.1 1157 7.6e-124 PREDICTED: rRNA 2'-O-methyltransferase fibrillarin [Tribolium castaneum]>gi|270003342|gb|EEZ99789.1| hypothetical protein TcasGA2_TC002569 [Tribolium castaneum] 746845440 XM_011054705.1 112 4.20717e-49 PREDICTED: Acromyrmex echinatior rRNA 2'-O-methyltransferase fibrillarin (LOC105145259), mRNA K14563 NOP1, FBL rRNA 2'-O-methyltransferase fibrillarin http://www.genome.jp/dbget-bin/www_bget?ko:K14563 Q8I1F4 1136 8.6e-123 rRNA 2'-O-methyltransferase fibrillarin OS=Drosophila erecta GN=Fib PE=3 SV=1 PF01189//PF08704//PF01269//PF01728//PF01135 16S rRNA methyltransferase RsmF//tRNA methyltransferase complex GCD14 subunit//Fibrillarin//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006479//GO:0009451//GO:0006364//GO:0032259//GO:0008033//GO:0046500//GO:0006464//GO:0030488 protein methylation//RNA modification//rRNA processing//methylation//tRNA processing//S-adenosylmethionine metabolic process//cellular protein modification process//tRNA methylation GO:0008168//GO:0004719//GO:0003723//GO:0016429 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//RNA binding//tRNA (adenine-N1-)-methyltransferase activity GO:0031515 tRNA (m1A) methyltransferase complex KOG1596 Fibrillarin and related nucleolar RNA-binding proteins Cluster-8309.47374 BP_3 194.39 3.87 2714 642913646 XP_008201102.1 2668 7.5e-299 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 2.4e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF03539//PF01055 Spumavirus aspartic protease (A9)//Glycosyl hydrolases family 31 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004190//GO:0004553 aspartic-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.47376 BP_3 870.07 5.07 8566 642923487 XP_008193531.1 372 4.1e-32 PREDICTED: RNA binding protein fox-1 homolog 3 isoform X3 [Tribolium castaneum] 642923486 XM_008195309.1 339 1.38923e-174 PREDICTED: Tribolium castaneum RNA binding protein fox-1 homolog 3 (LOC655682), transcript variant X3, mRNA K14946 RBFOX, FOX RNA binding protein fox-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14946 Q9NWB1 148 1.6e-07 RNA binding protein fox-1 homolog 1 OS=Homo sapiens GN=RBFOX1 PE=1 SV=2 PF00076//PF04117 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Mpv17 / PMP22 family -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.47377 BP_3 36.43 0.67 2931 546686197 ERL95577.1 364 1.2e-31 hypothetical protein D910_12838 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.47381 BP_3 17.04 1.97 709 642926739 XP_008194992.1 146 5.4e-07 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47382 BP_3 48.00 1.66 1688 571543791 XP_006561534.1 245 4.3e-18 PREDICTED: chaoptin-like isoform X2 [Apis mellifera]>gi|571543794|ref|XP_006561535.1| PREDICTED: chaoptin-like isoform X3 [Apis mellifera]>gi|571543797|ref|XP_006561536.1| PREDICTED: chaoptin-like isoform X4 [Apis mellifera]>gi|571543800|ref|XP_006561537.1| PREDICTED: chaoptin-like isoform X5 [Apis mellifera]>gi|571543803|ref|XP_006561538.1| PREDICTED: chaoptin-like isoform X6 [Apis mellifera]>gi|571543806|ref|XP_006561539.1| PREDICTED: chaoptin-like isoform X7 [Apis mellifera] -- -- -- -- -- -- -- -- -- D4A1J9 226 2.8e-17 Leucine-rich repeat and fibronectin type-III domain-containing protein 5 OS=Rattus norvegicus GN=Lrfn5 PE=1 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.47383 BP_3 161.64 3.86 2308 91085301 XP_968534.1 1697 2.5e-186 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum]>gi|270009220|gb|EFA05668.1| hypothetical protein TcasGA2_TC014946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 521 2.4e-51 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.47386 BP_3 2602.60 14.58 8894 189240947 XP_971362.2 2727 3.5e-305 PREDICTED: ecdysone-inducible protein E75 isoform X3 [Tribolium castaneum] 642934872 XM_966269.3 520 0 PREDICTED: Tribolium castaneum ecdysone-inducible protein E75 (LOC660005), transcript variant X3, mRNA K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1575 5.6e-173 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF03689//PF00105//PF00104 Nepovirus coat protein, N-terminal domain//Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0019028//GO:0005634//GO:0005667 viral capsid//nucleus//transcription factor complex -- -- Cluster-8309.47391 BP_3 23.83 1.19 1261 861605580 KMQ84383.1 273 1.8e-21 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47392 BP_3 1198.26 5.45 10888 270008428 EFA04876.1 9007 0.0e+00 hypothetical protein TcasGA2_TC014935 [Tribolium castaneum] -- -- -- -- -- K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 P42356 4980 0.0e+00 Phosphatidylinositol 4-kinase alpha OS=Homo sapiens GN=PI4KA PE=1 SV=3 PF13181//PF07721//PF08240//PF00899//PF00454//PF00106//PF13374//PF00515//PF13414//PF00107 Tetratricopeptide repeat//Tetratricopeptide repeat//Alcohol dehydrogenase GroES-like domain//ThiF family//Phosphatidylinositol 3- and 4-kinase//short chain dehydrogenase//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Zinc-binding dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0042802//GO:0016773//GO:0016491//GO:0008641//GO:0005515 identical protein binding//phosphotransferase activity, alcohol group as acceptor//oxidoreductase activity//small protein activating enzyme activity//protein binding -- -- KOG0902 Phosphatidylinositol 4-kinase Cluster-8309.47398 BP_3 60.30 3.24 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47402 BP_3 604.79 13.60 2435 91089063 XP_970679.1 2031 4.9e-225 PREDICTED: N-sulphoglucosamine sulphohydrolase isoform X1 [Tribolium castaneum]>gi|270012406|gb|EFA08854.1| hypothetical protein TcasGA2_TC006555 [Tribolium castaneum] 584037463 XM_006753050.1 45 1.06184e-11 PREDICTED: Myotis davidii N-sulfoglucosamine sulfohydrolase (SGSH), partial mRNA K01565 SGSH N-sulfoglucosamine sulfohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01565 P51688 1498 1.3e-164 N-sulphoglucosamine sulphohydrolase OS=Homo sapiens GN=SGSH PE=1 SV=1 PF00010//PF02076//PF00884//PF07931//PF01663//PF09004 Helix-loop-helix DNA-binding domain//Pheromone A receptor//Sulfatase//Chloramphenicol phosphotransferase-like protein//Type I phosphodiesterase / nucleotide pyrophosphatase//Domain of unknown function (DUF1891) GO:0007606//GO:0019236//GO:0055114//GO:0007186//GO:0008152 sensory perception of chemical stimulus//response to pheromone//oxidation-reduction process//G-protein coupled receptor signaling pathway//metabolic process GO:0004932//GO:0008168//GO:0008484//GO:0016706//GO:0046983//GO:0016740//GO:0005524//GO:0003824 mating-type factor pheromone receptor activity//methyltransferase activity//sulfuric ester hydrolase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//protein dimerization activity//transferase activity//ATP binding//catalytic activity GO:0016021 integral component of membrane KOG3867 Sulfatase Cluster-8309.47406 BP_3 98.56 1.90 2789 242018392 XP_002429661.1 645 2.9e-64 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 529 3.4e-52 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.4741 BP_3 51.10 0.88 3101 642927347 XP_008195231.1 719 8.5e-73 PREDICTED: uncharacterized protein C1orf112 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NSG2 157 5.2e-09 Uncharacterized protein C1orf112 OS=Homo sapiens GN=C1orf112 PE=1 SV=1 PF04428 Choline kinase N terminus -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.47412 BP_3 21.09 0.32 3451 546678825 ERL89370.1 1643 6.8e-180 hypothetical protein D910_06741 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2T9W3 343 1.6e-30 Coiled-coil domain-containing protein 63 OS=Bos taurus GN=CCDC63 PE=2 SV=1 PF04092 SRS domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.47415 BP_3 5.33 0.37 982 642922646 XP_971397.2 213 1.3e-14 PREDICTED: Krueppel-like factor 11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47416 BP_3 33.00 0.54 3230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47419 BP_3 11.78 1.19 770 642922539 XP_008193217.1 573 1.8e-56 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SPP0 239 4.0e-19 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47420 BP_3 258.54 4.77 2906 642922539 XP_008193217.1 573 6.8e-56 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SPP0 239 1.5e-18 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47422 BP_3 73.04 10.72 620 642922539 XP_008193217.1 573 1.4e-56 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SPP0 239 3.2e-19 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47423 BP_3 37.14 1.45 1526 270008621 EFA05069.1 151 3.1e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.47424 BP_3 264.15 9.16 1682 478256678 ENN76860.1 772 3.3e-79 hypothetical protein YQE_06701, partial [Dendroctonus ponderosae]>gi|546685125|gb|ERL94652.1| hypothetical protein D910_11927 [Dendroctonus ponderosae] -- -- -- -- -- K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47425 BP_3 432.26 8.51 2739 642916439 XP_008191027.1 1004 6.8e-106 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 430 1.0e-40 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF00606//PF10459//PF08651//PF06814//PF04111//PF05073//PF11744//PF00046//PF02184//PF09036//PF09392//PF02601//PF08702//PF05929//PF05478//PF01496 Herpesvirus Glycoprotein B//Peptidase S46//DASH complex subunit Duo1//Lung seven transmembrane receptor//Autophagy protein Apg6//Baculovirus P24 capsid protein//Aluminium activated malate transporter//Homeobox domain//HAT (Half-A-TPR) repeat//Bcr-Abl oncoprotein oligomerisation domain//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin//V-type ATPase 116kDa subunit family GO:0015031//GO:0007067//GO:0051258//GO:0006468//GO:0009069//GO:0006914//GO:0007165//GO:0009405//GO:0019069//GO:0006308//GO:0015743//GO:0015991//GO:0015992//GO:0006396//GO:0030168//GO:0016310 protein transport//mitotic nuclear division//protein polymerization//protein phosphorylation//serine family amino acid metabolic process//autophagy//signal transduction//pathogenesis//viral capsid assembly//DNA catabolic process//malate transport//ATP hydrolysis coupled proton transport//proton transport//RNA processing//platelet activation//phosphorylation GO:0015078//GO:0070009//GO:0005096//GO:0008855//GO:0003677//GO:0004674//GO:0005102//GO:0008239//GO:0030674 hydrogen ion transmembrane transporter activity//serine-type aminopeptidase activity//GTPase activator activity//exodeoxyribonuclease VII activity//DNA binding//protein serine/threonine kinase activity//receptor binding//dipeptidyl-peptidase activity//protein binding, bridging GO:0042729//GO:0005622//GO:0016021//GO:0033179//GO:0016020//GO:0005577//GO:0009318//GO:0019028//GO:0072686 DASH complex//intracellular//integral component of membrane//proton-transporting V-type ATPase, V0 domain//membrane//fibrinogen complex//exodeoxyribonuclease VII complex//viral capsid//mitotic spindle KOG3850 Predicted membrane protein Cluster-8309.47426 BP_3 21.65 1.04 1296 642939241 XP_008194774.1 1252 5.6e-135 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q4JM44 411 7.6e-39 Phosphatidylcholine:ceramide cholinephosphotransferase 2 OS=Rattus norvegicus GN=Sgms2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.47427 BP_3 23.00 0.84 1618 91091114 XP_966512.1 762 4.6e-78 PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|91091116|ref|XP_975893.1| PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|270014090|gb|EFA10538.1| hypothetical protein TcasGA2_TC012793 [Tribolium castaneum] 768428971 XM_011557345.1 165 1.37308e-78 PREDICTED: Plutella xylostella GTP-binding nuclear protein Ran (LOC105386728), mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 Q9VZ23 739 8.8e-77 GTP-binding nuclear protein Ran OS=Drosophila melanogaster GN=ran PE=1 SV=1 PF00025//PF01926//PF08477//PF04670//PF00910//PF00071//PF00503//PF02367//PF03193 ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Gtr1/RagA G protein conserved region//RNA helicase//Ras family//G-protein alpha subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258 GO:0007264//GO:0006184//GO:0002949//GO:0007186//GO:0006886//GO:0006913//GO:0007165 small GTPase mediated signal transduction//obsolete GTP catabolic process//tRNA threonylcarbamoyladenosine modification//G-protein coupled receptor signaling pathway//intracellular protein transport//nucleocytoplasmic transport//signal transduction GO:0003724//GO:0004871//GO:0019001//GO:0005525//GO:0003924//GO:0031683//GO:0003723 RNA helicase activity//signal transducer activity//guanyl nucleotide binding//GTP binding//GTPase activity//G-protein beta/gamma-subunit complex binding//RNA binding GO:0005622 intracellular KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-8309.47429 BP_3 26.79 3.97 617 642913461 XP_008201022.1 661 9.0e-67 PREDICTED: uncharacterized protein LOC663795 [Tribolium castaneum] -- -- -- -- -- K07524 RGS3 regulator of G-protein signalling 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07524 P17252 128 2.4e-06 Protein kinase C alpha type OS=Homo sapiens GN=PRKCA PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG0696 Serine/threonine protein kinase Cluster-8309.47430 BP_3 182.47 6.32 1683 642914933 XP_008190447.1 345 1.1e-29 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.47431 BP_3 72.00 0.89 4203 642929562 XP_008195885.1 2014 7.9e-223 PREDICTED: ankyrin repeat and IBR domain-containing protein 1-like [Tribolium castaneum]>gi|270010556|gb|EFA07004.1| hypothetical protein TcasGA2_TC009974 [Tribolium castaneum] 642929561 XM_008197663.1 153 1.69304e-71 PREDICTED: Tribolium castaneum ankyrin repeat and IBR domain-containing protein 1-like (LOC664247), mRNA -- -- -- -- -- -- -- -- -- -- -- -- GO:0043169 cation binding -- -- -- -- Cluster-8309.47435 BP_3 250.64 4.53 2956 91088353 XP_971591.1 1440 2.0e-156 PREDICTED: alpha/beta hydrolase domain-containing protein 13 [Tribolium castaneum]>gi|270011778|gb|EFA08226.1| hypothetical protein TcasGA2_TC005853 [Tribolium castaneum] -- -- -- -- -- K06889 K06889 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06889 Q7L211 757 1.3e-78 Alpha/beta hydrolase domain-containing protein 13 OS=Homo sapiens GN=ABHD13 PE=2 SV=1 PF01738//PF01764//PF02230//PF07859//PF00326//PF07819 Dienelactone hydrolase family//Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family//PGAP1-like protein GO:0006508//GO:0006505//GO:0008152//GO:0006886//GO:0006629 proteolysis//GPI anchor metabolic process//metabolic process//intracellular protein transport//lipid metabolic process GO:0008236//GO:0016788//GO:0016787 serine-type peptidase activity//hydrolase activity, acting on ester bonds//hydrolase activity -- -- KOG4391 Predicted alpha/beta hydrolase BEM46 Cluster-8309.47438 BP_3 8.98 0.44 1280 91084687 XP_968830.1 287 4.4e-23 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] -- -- -- -- -- K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q9NYA4 130 2.9e-06 Myotubularin-related protein 4 OS=Homo sapiens GN=MTMR4 PE=1 SV=2 PF13639//PF01363 Ring finger domain//FYVE zinc finger GO:0006470//GO:0006570//GO:0035335 protein dephosphorylation//tyrosine metabolic process//peptidyl-tyrosine dephosphorylation GO:0005515//GO:0046872//GO:0004725//GO:0008270 protein binding//metal ion binding//protein tyrosine phosphatase activity//zinc ion binding -- -- -- -- Cluster-8309.47439 BP_3 583.00 12.35 2567 91078584 XP_971954.1 1057 4.5e-112 PREDICTED: 3-hydroxyacyl-CoA dehydrogenase type-2 [Tribolium castaneum]>gi|270004043|gb|EFA00491.1| hypothetical protein TcasGA2_TC003351 [Tribolium castaneum] 769864511 XM_011645839.1 68 1.8352e-24 PREDICTED: Pogonomyrmex barbatus 3-hydroxyacyl-CoA dehydrogenase type-2 (LOC105431577), mRNA K08683 HSD17B10 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K08683 O18404 946 1.4e-100 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Drosophila melanogaster GN=scu PE=1 SV=1 PF01370//PF01073//PF00106 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008210//GO:0008152 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//estrogen metabolic process//metabolic process GO:0000166//GO:0003854//GO:0050662//GO:0003824//GO:0016491//GO:0016616 nucleotide binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA dehydrogenase Cluster-8309.47440 BP_3 76.09 0.53 7175 642927083 XP_008195130.1 5734 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927084 XM_008196909.1 473 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X2, mRNA -- -- -- -- Q9ULI1 411 4.2e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF07728//PF00004//PF03193//PF00005//PF00400//PF01637//PF00910//PF00931 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//WD domain, G-beta repeat//Archaeal ATPase//RNA helicase//NB-ARC domain -- -- GO:0005524//GO:0003723//GO:0043531//GO:0005515//GO:0003924//GO:0005525//GO:0016887//GO:0003724 ATP binding//RNA binding//ADP binding//protein binding//GTPase activity//GTP binding//ATPase activity//RNA helicase activity -- -- -- -- Cluster-8309.47442 BP_3 56.50 0.94 3191 270012300 EFA08748.1 2821 0.0e+00 hypothetical protein TcasGA2_TC006423 [Tribolium castaneum] 642932121 XM_001815605.2 463 0 PREDICTED: Tribolium castaneum uncharacterized LOC100142139 (LOC100142139), mRNA -- -- -- -- Q18PE1 381 5.6e-35 Protein Dok-7 OS=Homo sapiens GN=DOK7 PE=1 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.47443 BP_3 104.78 0.73 7168 642920223 XP_975548.2 2830 0.0e+00 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 604 1.8e-60 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF00170//PF02183//PF01180 bZIP transcription factor//Homeobox associated leucine zipper//Dihydroorotate dehydrogenase GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0043565//GO:0003700//GO:0016627 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0005737//GO:0005667 cytoplasm//transcription factor complex -- -- Cluster-8309.47444 BP_3 5.00 0.83 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47445 BP_3 494.69 6.92 3739 321462910 EFX73930.1 533 3.8e-51 hypothetical protein DAPPUDRAFT_307535 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q6UWB4 293 1.1e-24 Serine protease 55 OS=Homo sapiens GN=PRSS55 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.47447 BP_3 983.76 23.80 2284 270009116 EFA05564.1 1983 1.7e-219 hypothetical protein TcasGA2_TC015753 [Tribolium castaneum] 642926575 XM_008196705.1 163 2.52348e-77 PREDICTED: Tribolium castaneum putative fatty acyl-CoA reductase CG5065 (LOC656109), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1034 7.7e-111 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01118//PF01370//PF03015 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Male sterility protein GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0008210 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0080019//GO:0016616//GO:0051287//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.47448 BP_3 2497.00 101.71 1475 91084139 XP_976149.1 334 1.8e-28 PREDICTED: chromo domain-containing protein cec-1 [Tribolium castaneum]>gi|270006667|gb|EFA03115.1| hypothetical protein TcasGA2_TC013025 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.47449 BP_3 3631.78 21.40 8470 642911559 XP_970343.3 5242 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4083 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF04851//PF00176//PF04689//PF08074//PF03808 Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//DNA binding protein S1FA//CHDCT2 (NUC038) domain//Glycosyl transferase WecB/TagA/CpsF family GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0008270//GO:0016818//GO:0005524//GO:0003677//GO:0016787 zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//DNA binding//hydrolase activity GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.47450 BP_3 471.21 5.55 4387 91084287 XP_966951.1 533 4.5e-51 PREDICTED: rhythmically expressed gene 5 protein [Tribolium castaneum]>gi|270008733|gb|EFA05181.1| hypothetical protein TcasGA2_TC015311 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94913 211 4.0e-15 Rhythmically expressed gene 5 protein OS=Drosophila melanogaster GN=Reg-5 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47455 BP_3 165.42 1.61 5258 91081873 XP_968521.1 1429 6.8e-155 PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|642921577|ref|XP_008192430.1| PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|270005016|gb|EFA01464.1| hypothetical protein TcasGA2_TC007010 [Tribolium castaneum] 462361277 APGK01029116.1 57 4.92931e-18 Dendroctonus ponderosae Seq01029126, whole genome shotgun sequence K16717 CEP97 centrosomal protein CEP97 http://www.genome.jp/dbget-bin/www_bget?ko:K16717 Q8IW35 304 7.9e-26 Centrosomal protein of 97 kDa OS=Homo sapiens GN=CEP97 PE=1 SV=1 PF00612//PF01984//PF05531//PF13855 IQ calmodulin-binding motif//Double-stranded DNA-binding domain//Nucleopolyhedrovirus P10 protein//Leucine rich repeat -- -- GO:0005515//GO:0003677 protein binding//DNA binding GO:0019028 viral capsid KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.47456 BP_3 528.21 7.09 3885 91081873 XP_968521.1 2216 2.8e-246 PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|642921577|ref|XP_008192430.1| PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|270005016|gb|EFA01464.1| hypothetical protein TcasGA2_TC007010 [Tribolium castaneum] 462361277 APGK01029116.1 57 3.63327e-18 Dendroctonus ponderosae Seq01029126, whole genome shotgun sequence K16717 CEP97 centrosomal protein CEP97 http://www.genome.jp/dbget-bin/www_bget?ko:K16717 Q8IW35 751 8.6e-78 Centrosomal protein of 97 kDa OS=Homo sapiens GN=CEP97 PE=1 SV=1 PF00560//PF00612//PF05531//PF13855 Leucine Rich Repeat//IQ calmodulin-binding motif//Nucleopolyhedrovirus P10 protein//Leucine rich repeat -- -- GO:0005515 protein binding GO:0019028 viral capsid KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.47457 BP_3 378.48 6.41 3139 642916792 XP_008199505.1 1678 5.4e-184 PREDICTED: deformed epidermal autoregulatory factor 1 [Tribolium castaneum]>gi|270003059|gb|EEZ99506.1| hypothetical protein TcasGA2_TC000085 [Tribolium castaneum] 642916791 XM_008201283.1 177 5.74247e-85 PREDICTED: Tribolium castaneum deformed epidermal autoregulatory factor 1 (LOC655086), mRNA -- -- -- -- O88450 347 4.9e-31 Deformed epidermal autoregulatory factor 1 homolog OS=Rattus norvegicus GN=Deaf1 PE=1 SV=1 PF08064//PF00125//PF01342//PF15460 UME (NUC010) domain//Core histone H2A/H2B/H3/H4//SAND domain//Something about silencing, SAS, complex subunit 4 GO:0016310//GO:0009069//GO:0016573 phosphorylation//serine family amino acid metabolic process//histone acetylation GO:0004674//GO:0046872//GO:0003677//GO:0008270 protein serine/threonine kinase activity//metal ion binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.47458 BP_3 8.77 0.73 871 91078698 XP_971450.1 677 1.8e-68 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q5ZKN1 569 2.4e-57 Cyclin-dependent kinase 9 OS=Gallus gallus GN=CDK9 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.47459 BP_3 124.46 11.33 821 91078698 XP_971450.1 840 2.1e-87 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q5ZKN1 659 8.4e-68 Cyclin-dependent kinase 9 OS=Gallus gallus GN=CDK9 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.47460 BP_3 6.68 0.55 881 91078698 XP_971450.1 809 8.9e-84 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q5ZKN1 628 3.6e-64 Cyclin-dependent kinase 9 OS=Gallus gallus GN=CDK9 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.47461 BP_3 13.00 1.47 718 91078698 XP_971450.1 558 9.2e-55 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q6GLD8 508 2.4e-50 Cyclin-dependent kinase 9 OS=Xenopus tropicalis GN=cdk9 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.47464 BP_3 396.75 6.39 3286 646714573 KDR18486.1 3080 0.0e+00 Leucine-zipper-like transcriptional regulator 1 [Zootermopsis nevadensis] 527245427 XM_005140996.1 147 2.8583e-68 PREDICTED: Melopsittacus undulatus leucine-zipper-like transcription regulator 1 (LOC101875977), partial mRNA -- -- -- -- Q9CQ33 1429 1.7e-156 Leucine-zipper-like transcriptional regulator 1 OS=Mus musculus GN=Lztr1 PE=2 SV=2 PF03089//PF01344//PF11648//PF00651//PF07646 Recombination activating protein 2//Kelch motif//C-terminal domain of RIG-I//BTB/POZ domain//Kelch motif GO:0006310 DNA recombination GO:0003677//GO:0005515//GO:0016817 DNA binding//protein binding//hydrolase activity, acting on acid anhydrides GO:0005634 nucleus KOG0379 Kelch repeat-containing proteins Cluster-8309.47468 BP_3 238.25 2.07 5849 546682311 ERL92264.1 783 6.1e-80 hypothetical protein D910_09581 [Dendroctonus ponderosae] -- -- -- -- -- K15113 SLC25A28_37, MFRN solute carrier family 25 (mitochondrial iron transporter), member 28/37 http://www.genome.jp/dbget-bin/www_bget?ko:K15113 Q66H23 495 6.2e-48 Mitoferrin-1 OS=Rattus norvegicus GN=Slc25a37 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0760 Mitochondrial carrier protein MRS3/4 Cluster-8309.47469 BP_3 20.74 0.44 2542 642923795 XP_008193886.1 1065 5.3e-113 PREDICTED: uncharacterized protein LOC663689 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07650//PF00013//PF04999//PF13014 KH domain//KH domain//Cell division protein FtsL//KH domain GO:0051301//GO:0007049 cell division//cell cycle GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.47470 BP_3 44.00 1.60 1618 635120339 XP_007983241.1 348 4.7e-30 PREDICTED: histone-lysine N-methyltransferase SETMAR [Chlorocebus sabaeus] 687869404 LK939364.1 75 1.47374e-28 Angiostrongylus costaricensis genome assembly A_costaricensis_Costa_Rica ,scaffold ACOC_scaffold0000209 K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q53H47 345 4.3e-31 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF09339//PF01047//PF01498//PF01022//PF01325//PF00440//PF13404 IclR helix-turn-helix domain//MarR family//Transposase//Bacterial regulatory protein, arsR family//Iron dependent repressor, N-terminal DNA binding domain//Bacterial regulatory proteins, tetR family//AsnC-type helix-turn-helix domain GO:0015074//GO:0006313//GO:0006355 DNA integration//transposition, DNA-mediated//regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.47471 BP_3 45.00 2.52 1154 1263081 AAC52010.1 780 2.7e-80 mariner transposase [Homo sapiens] 689770398 LM265316.1 319 2.39576e-164 Strongylus vulgaris genome assembly S_vulgaris_Kentucky ,scaffold SVUK_scaffold0039628 K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q53H47 717 2.2e-74 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47474 BP_3 27.82 0.46 3238 642913555 XP_008201060.1 1983 2.4e-219 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X1 [Tribolium castaneum] 642913554 XM_008202838.1 516 0 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X1, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 Q9QXA6 1141 4.3e-123 b(0,+)-type amino acid transporter 1 OS=Mus musculus GN=Slc7a9 PE=1 SV=1 PF01194//PF04544//PF13520//PF00324 RNA polymerases N / 8 kDa subunit//Herpesvirus egress protein UL20//Amino acid permease//Amino acid permease GO:0003333//GO:0006206//GO:0019058//GO:0006144//GO:0006810//GO:0006351//GO:0006865//GO:0055085 amino acid transmembrane transport//pyrimidine nucleobase metabolic process//viral life cycle//purine nucleobase metabolic process//transport//transcription, DNA-templated//amino acid transport//transmembrane transport GO:0003899//GO:0003677//GO:0015171 DNA-directed RNA polymerase activity//DNA binding//amino acid transmembrane transporter activity GO:0005730//GO:0016020 nucleolus//membrane -- -- Cluster-8309.47476 BP_3 136.69 2.19 3305 642913555 XP_008201060.1 2234 1.9e-248 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X1 [Tribolium castaneum] 642913554 XM_008202838.1 620 0 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X1, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 P82252 1249 1.3e-135 b(0,+)-type amino acid transporter 1 OS=Rattus norvegicus GN=Slc7a9 PE=1 SV=1 PF00324//PF01194//PF13520//PF04544 Amino acid permease//RNA polymerases N / 8 kDa subunit//Amino acid permease//Herpesvirus egress protein UL20 GO:0003333//GO:0006206//GO:0006810//GO:0006144//GO:0019058//GO:0055085//GO:0006351//GO:0006865 amino acid transmembrane transport//pyrimidine nucleobase metabolic process//transport//purine nucleobase metabolic process//viral life cycle//transmembrane transport//transcription, DNA-templated//amino acid transport GO:0003677//GO:0015171//GO:0003899 DNA binding//amino acid transmembrane transporter activity//DNA-directed RNA polymerase activity GO:0005730//GO:0016020 nucleolus//membrane -- -- Cluster-8309.47477 BP_3 58.10 1.59 2054 91085955 XP_971224.1 1612 1.6e-176 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q75QN2 565 1.7e-56 Integrator complex subunit 8 OS=Homo sapiens GN=INTS8 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47478 BP_3 1216.83 207.73 574 291170322 ADD82417.1 469 1.5e-44 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 247 1.22236e-124 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- Q27017 132 7.6e-07 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.47479 BP_3 704.00 2.16 15974 642938845 XP_972555.3 12736 0.0e+00 PREDICTED: midasin [Tribolium castaneum] -- -- -- -- -- K14572 MDN1, REA1 midasin http://www.genome.jp/dbget-bin/www_bget?ko:K14572 Q9NU22 4992 0.0e+00 Midasin OS=Homo sapiens GN=MDN1 PE=1 SV=2 PF10662//PF00910//PF03193//PF07726//PF00005//PF02367//PF00437//PF00004//PF00448//PF07728//PF14532//PF01695//PF00158//PF06068//PF05496 Ethanolamine utilisation - propanediol utilisation//RNA helicase//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//SRP54-type protein, GTPase domain//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//IstB-like ATP binding protein//Sigma-54 interaction domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus GO:0006281//GO:0006810//GO:0006614//GO:0006355//GO:0006576//GO:0006310//GO:0002949 DNA repair//transport//SRP-dependent cotranslational protein targeting to membrane//regulation of transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0003924//GO:0005524//GO:0016887//GO:0003723//GO:0003678//GO:0003724//GO:0009378//GO:0005525 transcription factor binding//GTPase activity//ATP binding//ATPase activity//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity//GTP binding GO:0009379//GO:0005667//GO:0005657 Holliday junction helicase complex//transcription factor complex//replication fork KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.47480 BP_3 109.28 2.31 2567 859132801 AKO63316.1 1708 1.5e-187 acetyl CoA acetyltransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 1343 1.3e-146 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF00108//PF02803 Thiolase, N-terminal domain//Thiolase, C-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.47481 BP_3 27.73 0.51 2907 332376294 AEE63287.1 1800 3.6e-198 unknown [Dendroctonus ponderosae]>gi|478257770|gb|ENN77913.1| hypothetical protein YQE_05590, partial [Dendroctonus ponderosae] 642933156 XM_968826.3 47 9.81639e-13 PREDICTED: Tribolium castaneum trehalase (LOC662746), transcript variant X2, mRNA K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1648 6.2e-182 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.47485 BP_3 74.00 0.80 4766 270001609 EEZ98056.1 2859 0.0e+00 hypothetical protein TcasGA2_TC000461 [Tribolium castaneum] 827556978 XM_004930671.2 65 1.59454e-22 PREDICTED: Bombyx mori major facilitator superfamily domain-containing protein 6 (LOC101746863), mRNA -- -- -- -- Q1LUQ4 968 7.2e-103 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690//PF01306 Major Facilitator Superfamily//LacY proton/sugar symporter GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG3762 Predicted transporter Cluster-8309.47486 BP_3 43.13 0.80 2882 827556337 XP_012549527.1 234 1.4e-16 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X2 [Bombyx mori] -- -- -- -- -- K03103 MINPP1 multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K03103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47489 BP_3 116.53 0.85 6888 349584988 BAL03254.1 1867 1.4e-205 93 kDa serpin [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8TMP0 426 7.4e-40 Uncharacterized serpin-like protein MA_2613/MA_2612 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=MA_2613/MA_2612 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47490 BP_3 900.70 7.96 5744 642925017 XP_008194137.1 3852 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X1 [Tribolium castaneum] 462328174 APGK01040787.1 46 7.01939e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.9e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.47491 BP_3 248.69 7.00 2003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47493 BP_3 237.24 0.61 18986 642928205 XP_008195489.1 12645 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal [Tribolium castaneum] 620960012 XM_007666944.1 166 4.56535e-78 PREDICTED: Ornithorhynchus anatinus dynein, axonemal, heavy chain 10 (DNAH10), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8IVF4 9590 0.0e+00 Dynein heavy chain 10, axonemal OS=Homo sapiens GN=DNAH10 PE=1 SV=4 PF07728//PF15957//PF03028//PF05197//PF00437//PF00004//PF04136//PF00370//PF03938//PF02562//PF02782 AAA domain (dynein-related subfamily)//Commissureless//Dynein heavy chain and region D6 of dynein motor//TRIC channel//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Sec34-like family//FGGY family of carbohydrate kinases, N-terminal domain//Outer membrane protein (OmpH-like)//PhoH-like protein//FGGY family of carbohydrate kinases, C-terminal domain GO:0007017//GO:0006812//GO:0005975//GO:0007018//GO:0007411//GO:0015672//GO:0006810//GO:0006886 microtubule-based process//cation transport//carbohydrate metabolic process//microtubule-based movement//axon guidance//monovalent inorganic cation transport//transport//intracellular protein transport GO:0051082//GO:0016887//GO:0005524//GO:0005261//GO:0016773//GO:0003777 unfolded protein binding//ATPase activity//ATP binding//cation channel activity//phosphotransferase activity, alcohol group as acceptor//microtubule motor activity GO:0005801//GO:0016020//GO:0030286//GO:0005874 cis-Golgi network//membrane//dynein complex//microtubule -- -- Cluster-8309.47495 BP_3 110.63 3.23 1943 642914567 XP_008190268.1 327 1.5e-27 PREDICTED: uncharacterized protein LOC103312147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47497 BP_3 568.21 10.98 2786 478255924 ENN76126.1 1824 5.7e-201 hypothetical protein YQE_07346, partial [Dendroctonus ponderosae]>gi|546676527|gb|ERL87521.1| hypothetical protein D910_04913 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1DH70 1482 1.1e-162 Innexin shaking-B OS=Aedes aegypti GN=shakB PE=3 SV=1 PF00876//PF06753 Innexin//Bradykinin GO:0007165//GO:0006950 signal transduction//response to stress GO:0005179 hormone activity GO:0005921//GO:0005576 gap junction//extracellular region -- -- Cluster-8309.47498 BP_3 13.36 1.55 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.475 BP_3 3.17 0.33 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47500 BP_3 6.00 0.82 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47505 BP_3 48.95 1.03 2578 642939069 XP_008200209.1 1427 5.7e-155 PREDICTED: HIV Tat-specific factor 1 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K13093 HTATSF1 HIV Tat-specific factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13093 Q5RB63 749 9.7e-78 HIV Tat-specific factor 1 homolog OS=Pongo abelii GN=HTATSF1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1548 Transcription elongation factor TAT-SF1 Cluster-8309.47507 BP_3 468.88 36.79 906 642917710 XP_008191340.1 397 5.4e-36 PREDICTED: ninjurin-1 [Tribolium castaneum]>gi|270003379|gb|EEZ99826.1| hypothetical protein TcasGA2_TC002607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70617 184 1.1e-12 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF04923//PF02724//PF06459 Ninjurin//CDC45-like protein//Ryanodine Receptor TM 4-6 GO:0007155//GO:0006874//GO:0006816//GO:0006270//GO:0042246 cell adhesion//cellular calcium ion homeostasis//calcium ion transport//DNA replication initiation//tissue regeneration GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.47509 BP_3 2174.00 152.25 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47510 BP_3 272.40 3.36 4204 91076340 XP_971067.1 2071 2.0e-229 PREDICTED: peroxisomal N(1)-acetyl-spermine/spermidine oxidase [Tribolium castaneum]>gi|270002541|gb|EEZ98988.1| hypothetical protein TcasGA2_TC004849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q865R1 687 2.4e-70 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus GN=PAOX PE=1 SV=3 PF06100//PF01266//PF00979//PF01134//PF00899//PF01494//PF07992//PF01593 MCRA family//FAD dependent oxidoreductase//Reovirus outer capsid protein, Sigma 3//Glucose inhibited division protein A//ThiF family//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase GO:0006631//GO:0055114//GO:0008033//GO:0019058 fatty acid metabolic process//oxidation-reduction process//tRNA processing//viral life cycle GO:0050660//GO:0008641//GO:0071949//GO:0005198//GO:0050151//GO:0016491 flavin adenine dinucleotide binding//small protein activating enzyme activity//FAD binding//structural molecule activity//oleate hydratase activity//oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.47511 BP_3 55.36 1.13 2659 332374794 AEE62538.1 706 2.4e-71 unknown [Dendroctonus ponderosae]>gi|546674015|gb|ERL85508.1| hypothetical protein D910_02927 [Dendroctonus ponderosae] -- -- -- -- -- K01444 AGA, aspG N4-(beta-N-acetylglucosaminyl)-L-asparaginase http://www.genome.jp/dbget-bin/www_bget?ko:K01444 Q64191 653 1.4e-66 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Mus musculus GN=Aga PE=2 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1593 Asparaginase Cluster-8309.47514 BP_3 1577.25 34.12 2520 270006157 EFA02605.1 2232 2.5e-248 hypothetical protein TcasGA2_TC008324 [Tribolium castaneum] 332375782 BT128071.1 218 7.43028e-108 Dendroctonus ponderosae clone DPO116_B20 unknown mRNA K01892 HARS, hisS histidyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01892 Q61035 1637 1.0e-180 Histidine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Hars PE=2 SV=2 PF05073//PF00458//PF00587//PF00152 Baculovirus P24 capsid protein//WHEP-TRS domain//tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N) GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity GO:0019028 viral capsid KOG1936 Histidyl-tRNA synthetase Cluster-8309.47515 BP_3 326.02 8.84 2069 646718490 KDR20930.1 993 9.6e-105 hypothetical protein L798_03868 [Zootermopsis nevadensis] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 D4A4K3 586 6.2e-59 Beclin 1-associated autophagy-related key regulator OS=Rattus norvegicus GN=Atg14 PE=3 SV=1 PF10186//PF00643 Vacuolar sorting 38 and autophagy-related subunit 14//B-box zinc finger GO:0010508 positive regulation of autophagy GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.47517 BP_3 53.73 0.39 6898 546676860 ERL87797.1 1153 9.0e-123 hypothetical protein D910_05186 [Dendroctonus ponderosae] 512862182 XM_002935331.2 57 6.47441e-18 PREDICTED: Xenopus (Silurana) tropicalis enhancer of rudimentary homolog (Drosophila) (erh), mRNA -- -- -- -- Q8CIF6 750 2.0e-77 SID1 transmembrane family member 2 OS=Mus musculus GN=Sidt2 PE=1 SV=1 PF00097//PF01133//PF08030//PF13965//PF00175 Zinc finger, C3HC4 type (RING finger)//Enhancer of rudimentary//Ferric reductase NAD binding domain//dsRNA-gated channel SID-1//Oxidoreductase NAD-binding domain GO:0006221//GO:0015931//GO:0045747//GO:0007049//GO:0055114//GO:0033227 pyrimidine nucleotide biosynthetic process//nucleobase-containing compound transport//positive regulation of Notch signaling pathway//cell cycle//oxidation-reduction process//dsRNA transport GO:0016491//GO:0051033//GO:0046872 oxidoreductase activity//RNA transmembrane transporter activity//metal ion binding GO:0016021 integral component of membrane KOG1766 Enhancer of rudimentary Cluster-8309.47518 BP_3 192.51 5.93 1857 189233648 XP_972556.2 711 4.3e-72 PREDICTED: beta-arrestin-1 isoform X4 [Tribolium castaneum] 642910565 XM_967463.3 283 4.00799e-144 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X4, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P51485 395 7.8e-37 Probable beta-arrestin OS=Caenorhabditis elegans GN=arr-1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.47519 BP_3 240.02 5.28 2481 642910564 XP_008200268.1 1299 3.8e-140 PREDICTED: arrestin red cell isoform 2 isoform X3 [Tribolium castaneum] 525343481 NM_001279418.1 174 2.10669e-83 Bombyx mori beta-arrestin-1-like (LOC101742650), mRNA >gnl|BL_ORD_ID|14275337 Bombyx mori strain Qiufeng x Baiyu nonvisual arrestin mRNA, complete cds K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 Q4R562 933 4.3e-99 Beta-arrestin-1 OS=Macaca fascicularis GN=ARRB1 PE=2 SV=1 PF00950 ABC 3 transport family GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016020 membrane KOG3865 Arrestin Cluster-8309.47520 BP_3 1.00 5.54 260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47521 BP_3 41.49 0.67 3290 642910562 XP_008200267.1 1299 5.0e-140 PREDICTED: arrestin red cell isoform 2 isoform X2 [Tribolium castaneum] 642910561 XM_008202045.1 274 7.20662e-139 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X2, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P49407 933 5.7e-99 Beta-arrestin-1 OS=Homo sapiens GN=ARRB1 PE=1 SV=2 PF00950 ABC 3 transport family GO:0006810 transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016020 membrane KOG3865 Arrestin Cluster-8309.47522 BP_3 24.70 0.60 2264 189233648 XP_972556.2 1826 2.7e-201 PREDICTED: beta-arrestin-1 isoform X4 [Tribolium castaneum] 642910565 XM_967463.3 515 0 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X4, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 Q4R562 1154 9.3e-125 Beta-arrestin-1 OS=Macaca fascicularis GN=ARRB1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.47524 BP_3 56.93 1.12 2740 91079879 XP_975774.1 464 2.8e-43 PREDICTED: uncharacterized protein LOC655985 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04889 Cwf15/Cwc15 cell cycle control protein GO:0000398 mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex -- -- Cluster-8309.47526 BP_3 456.80 1.82 12418 642914032 XP_008201515.1 5554 0.0e+00 PREDICTED: syntaxin-binding protein 5 isoform X2 [Tribolium castaneum] 751777385 XM_011199394.1 86 8.84214e-34 PREDICTED: Bactrocera dorsalis probable ATP-dependent RNA helicase DDX10 (LOC105222182), mRNA K08518 STXBP5 syntaxin-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08518 Q9WU70 2011 2.1e-223 Syntaxin-binding protein 5 OS=Rattus norvegicus GN=Stxbp5 PE=1 SV=1 PF00957//PF00802//PF11616//PF04992//PF00400//PF11427//PF00270//PF01218 Synaptobrevin//Pneumovirus attachment glycoprotein G//WD repeat binding protein EZH2//RNA polymerase Rpb1, domain 6//WD domain, G-beta repeat//Tc3 transposase//DEAD/DEAH box helicase//Coproporphyrinogen III oxidase GO:0006351//GO:0015994//GO:0006144//GO:0006206//GO:0006479//GO:0016192//GO:0006554//GO:0006779//GO:0055114 transcription, DNA-templated//chlorophyll metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//protein methylation//vesicle-mediated transport//lysine catabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0018024//GO:0003677//GO:0004109//GO:0005515//GO:0003676//GO:0005524//GO:0003899 histone-lysine N-methyltransferase activity//DNA binding//coproporphyrinogen oxidase activity//protein binding//nucleic acid binding//ATP binding//DNA-directed RNA polymerase activity GO:0016021//GO:0055036//GO:0005730 integral component of membrane//virion membrane//nucleolus KOG0343 RNA Helicase Cluster-8309.47527 BP_3 88.03 1.22 3766 642921579 XP_008192431.1 1018 2.2e-107 PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum]>gi|642921581|ref|XP_008192432.1| PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2LZ59 873 5.9e-92 MOB kinase activator-like 2 OS=Drosophila pseudoobscura pseudoobscura GN=Mob1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.47528 BP_3 2737.09 37.83 3779 546673579 ERL85150.1 2312 2.0e-257 hypothetical protein D910_02572 [Dendroctonus ponderosae] 381143842 JN171289.1 206 5.24234e-101 Bembidion scopulinum voucher DRMaddison:DNA1282 topoisomerase I gene, partial cds K03163 TOP1 DNA topoisomerase I http://www.genome.jp/dbget-bin/www_bget?ko:K03163 P30189 1944 3.8e-216 DNA topoisomerase 1 OS=Drosophila melanogaster GN=Top1 PE=1 SV=1 PF02919//PF01028 Eukaryotic DNA topoisomerase I, DNA binding fragment//Eukaryotic DNA topoisomerase I, catalytic core GO:0006265 DNA topological change GO:0003917//GO:0003677//GO:0003918 DNA topoisomerase type I activity//DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005694 chromosome KOG0981 DNA topoisomerase I Cluster-8309.47530 BP_3 14.56 0.33 2438 91077292 XP_974520.1 2379 2.2e-265 PREDICTED: splicing factor 3A subunit 3 [Tribolium castaneum]>gi|270002083|gb|EEZ98530.1| hypothetical protein TcasGA2_TC001034 [Tribolium castaneum] 242011600 XM_002426492.1 125 3.58796e-56 Pediculus humanus corporis Splicing factor 3A subunit, putative, mRNA K12827 SF3A3, SAP61, PRP9 splicing factor 3A subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12827 Q12874 1856 4.0e-206 Splicing factor 3A subunit 3 OS=Homo sapiens GN=SF3A3 PE=1 SV=1 -- -- -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus KOG2636 Splicing factor 3a, subunit 3 Cluster-8309.47531 BP_3 797.47 27.79 1675 270009029 EFA05477.1 800 1.9e-82 hypothetical protein TcasGA2_TC015661 [Tribolium castaneum] -- -- -- -- -- K10606 FANCL, PHF9 E3 ubiquitin-protein ligase FANCL http://www.genome.jp/dbget-bin/www_bget?ko:K10606 Q9NW38 346 3.4e-31 E3 ubiquitin-protein ligase FANCL OS=Homo sapiens GN=FANCL PE=1 SV=2 PF13639//PF12678//PF12906//PF12861//PF00628 Ring finger domain//RING-H2 zinc finger//RING-variant domain//Anaphase-promoting complex subunit 11 RING-H2 finger//PHD-finger GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//protein binding//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.47532 BP_3 404.00 5.43 3879 642930592 XP_008198268.1 295 1.6e-23 PREDICTED: calponin homology domain-containing protein DDB_G0272472 [Tribolium castaneum]>gi|270010755|gb|EFA07203.1| hypothetical protein TcasGA2_TC010210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04610//PF06624 TrbL/VirB6 plasmid conjugal transfer protein//Ribosome associated membrane protein RAMP4 GO:0030255 protein secretion by the type IV secretion system -- -- GO:0005783 endoplasmic reticulum -- -- Cluster-8309.47535 BP_3 770.26 22.69 1928 91080555 XP_967130.1 706 1.7e-71 PREDICTED: clathrin light chain isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWA1 368 1.1e-33 Clathrin light chain OS=Drosophila melanogaster GN=Clc PE=2 SV=1 PF01086//PF13855 Clathrin light chain//Leucine rich repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle -- -- Cluster-8309.47537 BP_3 29.62 0.66 2465 642919416 XP_008191861.1 399 8.7e-36 PREDICTED: F-box/LRR-repeat protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K04644 CLTA, LCA clathrin light chain A http://www.genome.jp/dbget-bin/www_bget?ko:K04644 Q8IY45 297 2.4e-25 Protein AMN1 homolog OS=Homo sapiens GN=AMN1 PE=2 SV=4 PF13855//PF01086 Leucine rich repeat//Clathrin light chain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030130//GO:0030132 clathrin coat of trans-Golgi network vesicle//clathrin coat of coated pit -- -- Cluster-8309.47538 BP_3 135.56 3.23 2314 642919416 XP_008191861.1 399 8.1e-36 PREDICTED: F-box/LRR-repeat protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IY45 297 2.2e-25 Protein AMN1 homolog OS=Homo sapiens GN=AMN1 PE=2 SV=4 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.47539 BP_3 129.11 2.19 3137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47541 BP_3 146.21 2.17 3543 478254798 ENN75034.1 2058 5.3e-228 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 227 1.04089e-112 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 1138 1.0e-122 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF03526//PF06870//PF00887 Colicin E1 (microcin) immunity protein//A49-like RNA polymerase I associated factor//Acyl CoA binding protein GO:0006351//GO:0006144//GO:0006206//GO:0006955//GO:0030153 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//immune response//bacteriocin immunity GO:0000062//GO:0003899//GO:0003677//GO:0015643 fatty-acyl-CoA binding//DNA-directed RNA polymerase activity//DNA binding//toxic substance binding GO:0005634//GO:0019814//GO:0005730 nucleus//immunoglobulin complex//nucleolus KOG3530 FERM domain protein EHM2 Cluster-8309.47542 BP_3 23.35 0.46 2714 91091180 XP_971767.1 828 1.7e-85 PREDICTED: uncharacterized protein LOC660444 [Tribolium castaneum]>gi|270013120|gb|EFA09568.1| hypothetical protein TcasGA2_TC011682 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VCH8 313 3.7e-27 Transmembrane protein 65 OS=Bos taurus GN=TMEM65 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4619 Uncharacterized conserved protein Cluster-8309.47543 BP_3 32.86 0.39 4366 642913983 XP_008201501.1 1894 6.8e-209 PREDICTED: probable ATP-dependent RNA helicase DDX56 [Tribolium castaneum]>gi|270002128|gb|EEZ98575.1| hypothetical protein TcasGA2_TC001089 [Tribolium castaneum] 642913982 XM_008203279.1 298 4.36793e-152 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX56 (LOC655034), mRNA K14810 DDX56, DBP9 ATP-dependent RNA helicase DDX56/DBP9 http://www.genome.jp/dbget-bin/www_bget?ko:K14810 Q9D0R4 1211 4.4e-131 Probable ATP-dependent RNA helicase DDX56 OS=Mus musculus GN=Ddx56 PE=2 SV=1 PF02732//PF04851//PF15310//PF00580//PF01484//PF00503//PF00270//PF07652 ERCC4 domain//Type III restriction enzyme, res subunit//Vitamin A-deficiency (VAD) rat model signalling//UvrD/REP helicase N-terminal domain//Nematode cuticle collagen N-terminal domain//G-protein alpha subunit//DEAD/DEAH box helicase//Flavivirus DEAD domain GO:0007186//GO:0007283//GO:0007165//GO:0019079 G-protein coupled receptor signaling pathway//spermatogenesis//signal transduction//viral genome replication GO:0019001//GO:0004871//GO:0003676//GO:0004518//GO:0005524//GO:0016787//GO:0003677//GO:0031683//GO:0008026//GO:0003924//GO:0042302 guanyl nucleotide binding//signal transducer activity//nucleic acid binding//nuclease activity//ATP binding//hydrolase activity//DNA binding//G-protein beta/gamma-subunit complex binding//ATP-dependent helicase activity//GTPase activity//structural constituent of cuticle -- -- KOG0346 RNA helicase Cluster-8309.47544 BP_3 210.46 5.38 2177 189236990 XP_970274.2 792 2.1e-81 PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|642921800|ref|XP_008199324.1| PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|270008114|gb|EFA04562.1| hypothetical protein TcasGA2_TC010947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZS10 145 8.9e-08 C-type lectin domain family 17, member A OS=Homo sapiens GN=CLEC17A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47545 BP_3 12.95 1.56 693 478260276 ENN80028.1 211 1.5e-14 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P17012 167 8.0e-11 Zinc finger X-chromosomal protein OS=Mus musculus GN=Zfx PE=1 SV=2 PF16622//PF00096//PF13465//PF04988//PF01096 zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//Transcription factor S-II (TFIIS) GO:0006351 transcription, DNA-templated GO:0003676//GO:0003677//GO:0008270//GO:0046872 nucleic acid binding//DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.47547 BP_3 639.83 11.06 3080 642920934 XP_001814127.2 1388 2.3e-150 PREDICTED: yemanuclein-alpha isoform X2 [Tribolium castaneum] -- -- -- -- -- K17492 UBN ubinuclein http://www.genome.jp/dbget-bin/www_bget?ko:K17492 Q80WC1 453 2.4e-43 Ubinuclein-2 OS=Mus musculus GN=Ubn2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47548 BP_3 64.34 1.03 3299 91077726 XP_975075.1 2465 3.1e-275 PREDICTED: protein inturned [Tribolium castaneum]>gi|270002215|gb|EEZ98662.1| hypothetical protein TcasGA2_TC001193 [Tribolium castaneum] 642914358 XM_969982.2 79 1.81482e-30 PREDICTED: Tribolium castaneum protein inturned (LOC663956), mRNA -- -- -- -- Q2I0E5 577 1.1e-57 Protein inturned OS=Xenopus laevis GN=intu PE=2 SV=1 PF03276 Spumavirus gag protein GO:0019076//GO:0075521//GO:0046718 viral release from host cell//microtubule-dependent intracellular transport of viral material towards nucleus//viral entry into host cell -- -- GO:0030430//GO:0044163//GO:0042025//GO:0019028 host cell cytoplasm//host cytoskeleton//host cell nucleus//viral capsid -- -- Cluster-8309.47549 BP_3 181.84 2.85 3371 91077726 XP_975075.1 2341 7.7e-261 PREDICTED: protein inturned [Tribolium castaneum]>gi|270002215|gb|EEZ98662.1| hypothetical protein TcasGA2_TC001193 [Tribolium castaneum] 642914358 XM_969982.2 79 1.85487e-30 PREDICTED: Tribolium castaneum protein inturned (LOC663956), mRNA -- -- -- -- F6U5F9 722 1.7e-74 Protein inturned OS=Xenopus tropicalis GN=intu PE=3 SV=1 PF03276//PF15281 Spumavirus gag protein//Consortin C-terminus GO:0046718//GO:0019076//GO:0075521//GO:0042998 viral entry into host cell//viral release from host cell//microtubule-dependent intracellular transport of viral material towards nucleus//positive regulation of Golgi to plasma membrane protein transport GO:0071253 connexin binding GO:0042025//GO:0019028//GO:0005802//GO:0030430//GO:0044163 host cell nucleus//viral capsid//trans-Golgi network//host cell cytoplasm//host cytoskeleton -- -- Cluster-8309.4755 BP_3 4.00 1.03 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47550 BP_3 208.26 5.19 2227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09004 Domain of unknown function (DUF1891) GO:0055114 oxidation-reduction process GO:0016706//GO:0008168 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//methyltransferase activity -- -- -- -- Cluster-8309.47552 BP_3 62.96 1.88 1906 665789011 XP_008560125.1 1371 1.3e-148 PREDICTED: uncharacterized protein LOC103580223 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00412//PF00751 LIM domain//DM DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565 zinc ion binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.47553 BP_3 167.73 5.10 1878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47554 BP_3 232.25 2.52 4742 478259245 ENN79147.1 2721 9.4e-305 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] 260807434 XM_002598468.1 165 4.08067e-78 Branchiostoma floridae hypothetical protein, mRNA K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 2277 1.2e-254 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF07728//PF01745//PF08752//PF01695//PF00158//PF01926//PF01057//PF00004//PF02367//PF02562//PF00931//PF06068//PF05496//PF07724//PF07726//PF01299//PF00005//PF01637//PF00910//PF06800 AAA domain (dynein-related subfamily)//Isopentenyl transferase//Coatomer gamma subunit appendage platform subdomain//IstB-like ATP binding protein//Sigma-54 interaction domain//50S ribosome-binding GTPase//Parvovirus non-structural protein NS1//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//NB-ARC domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Lysosome-associated membrane glycoprotein (Lamp)//ABC transporter//Archaeal ATPase//RNA helicase//Sugar transport protein GO:0016114//GO:0006886//GO:0006281//GO:0016192//GO:0019079//GO:0006694//GO:0009058//GO:0034219//GO:0006355//GO:0008643//GO:0006310//GO:0002949 terpenoid biosynthetic process//intracellular protein transport//DNA repair//vesicle-mediated transport//viral genome replication//steroid biosynthetic process//biosynthetic process//carbohydrate transmembrane transport//regulation of transcription, DNA-templated//carbohydrate transport//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005198//GO:0008134//GO:0015144//GO:0005524//GO:0016887//GO:0004161//GO:0043531//GO:0003723//GO:0003678//GO:0003724//GO:0009378//GO:0005525 structural molecule activity//transcription factor binding//carbohydrate transmembrane transporter activity//ATP binding//ATPase activity//dimethylallyltranstransferase activity//ADP binding//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity//GTP binding GO:0009379//GO:0016021//GO:0030126//GO:0005667//GO:0005657//GO:0016020 Holliday junction helicase complex//integral component of membrane//COPI vesicle coat//transcription factor complex//replication fork//membrane KOG0741 AAA+-type ATPase Cluster-8309.47556 BP_3 36.37 0.41 4521 642911937 XP_008199029.1 3664 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 525 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1725 1.1e-190 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF14604//PF00023//PF00018//PF03114//PF07043//PF08397//PF13606//PF01412 Variant SH3 domain//Ankyrin repeat//SH3 domain//BAR domain//Protein of unknown function (DUF1328)//IRSp53/MIM homology domain//Ankyrin repeat//Putative GTPase activating protein for Arf GO:0007009 plasma membrane organization GO:0005096//GO:0005515 GTPase activator activity//protein binding GO:0005886//GO:0005737 plasma membrane//cytoplasm KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.47557 BP_3 1.00 45.97 208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47559 BP_3 176.26 0.60 14374 189241098 XP_971301.2 11947 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13D [Tribolium castaneum] -- -- -- -- -- K19527 VPS13D vacuolar protein sorting-associated protein 13D http://www.genome.jp/dbget-bin/www_bget?ko:K19527 Q5THJ4 2017 5.0e-224 Vacuolar protein sorting-associated protein 13D OS=Homo sapiens GN=VPS13D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.4756 BP_3 5.74 0.54 800 642925206 XP_008194468.1 434 2.5e-40 PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum]>gi|642925208|ref|XP_008194469.1| PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum] -- -- -- -- -- K15153 MED31, SOH1 mediator of RNA polymerase II transcription subunit 31 http://www.genome.jp/dbget-bin/www_bget?ko:K15153 Q17DI7 357 8.6e-33 Mediator of RNA polymerase II transcription subunit 31 OS=Aedes aegypti GN=MED31 PE=3 SV=1 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4086 Transcriptional regulator SOH1 Cluster-8309.47561 BP_3 15.91 0.32 2726 91079959 XP_969470.1 510 1.3e-48 PREDICTED: three-prime repair exonuclease 1 [Tribolium castaneum]>gi|270003252|gb|EEZ99699.1| hypothetical protein TcasGA2_TC002459 [Tribolium castaneum] -- -- -- -- -- K10791 TREX2 three prime repair exonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10791 Q9R1A9 252 4.4e-20 Three prime repair exonuclease 2 OS=Mus musculus GN=Trex2 PE=2 SV=1 PF13482//PF03104 RNase_H superfamily//DNA polymerase family B, exonuclease domain -- -- GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- -- -- Cluster-8309.47562 BP_3 58.81 0.78 3913 270000732 EEZ97179.1 2324 8.4e-259 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] 642937909 XM_008202132.1 232 1.91197e-115 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 783 1.7e-81 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 PF00096//PF06220 Zinc finger, C2H2 type//U1 zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.47568 BP_3 92.85 5.03 1181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4757 BP_3 77.87 8.24 747 642925206 XP_008194468.1 623 2.8e-62 PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum]>gi|642925208|ref|XP_008194469.1| PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum] -- -- -- -- -- K15153 MED31, SOH1 mediator of RNA polymerase II transcription subunit 31 http://www.genome.jp/dbget-bin/www_bget?ko:K15153 Q28FE2 482 2.6e-47 Mediator of RNA polymerase II transcription subunit 31 OS=Xenopus tropicalis GN=med31 PE=2 SV=2 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4086 Transcriptional regulator SOH1 Cluster-8309.47572 BP_3 38.55 0.39 5040 91086227 XP_972385.1 1443 1.5e-156 PREDICTED: putative GPI-anchor transamidase [Tribolium castaneum] 820835140 XM_012484551.1 290 1.41345e-147 PREDICTED: Apis florea putative GPI-anchor transamidase (LOC105735008), mRNA K05290 PIGK phosphatidylinositol glycan, class K http://www.genome.jp/dbget-bin/www_bget?ko:K05290 Q8T4E1 1232 1.9e-133 Putative GPI-anchor transamidase OS=Drosophila melanogaster GN=CG4406 PE=2 SV=1 PF01979//PF00962//PF01650 Amidohydrolase family//Adenosine/AMP deaminase//Peptidase C13 family GO:0006508 proteolysis GO:0019239//GO:0008233//GO:0016787 deaminase activity//peptidase activity//hydrolase activity -- -- KOG1349 Gpi-anchor transamidase Cluster-8309.47573 BP_3 292.51 2.34 6323 642936157 XP_008198320.1 2712 1.4e-303 PREDICTED: transcription factor RFX3 isoform X2 [Tribolium castaneum] 620977287 XM_007670933.1 80 9.71757e-31 PREDICTED: Ornithorhynchus anatinus regulatory factor X, 2 (influences HLA class II expression) (RFX2), mRNA K09173 RFX1_2_3 regulatory factor X 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09173 Q0V9K5 1350 4.9e-147 Transcription factor RFX3 OS=Xenopus tropicalis GN=rfx3 PE=2 SV=2 PF02257 RFX DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3712 RFX family transcription factor Cluster-8309.47575 BP_3 22.68 2.06 822 642915266 XP_971845.3 235 3.0e-17 PREDICTED: sorting nexin-16 [Tribolium castaneum]>gi|270003912|gb|EFA00360.1| hypothetical protein TcasGA2_TC003202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4758 BP_3 5.35 0.37 984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47582 BP_3 404.60 1.02 19327 642929424 XP_008195834.1 3477 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X2 [Tribolium castaneum] 642929421 XM_008197611.1 179 2.75778e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q7TMR0 1024 9.4e-109 Lysosomal Pro-X carboxypeptidase OS=Mus musculus GN=Prcp PE=2 SV=2 PF04564//PF02198//PF06638//PF11789//PF08926//PF07647//PF01429//PF08273//PF01221//PF05577//PF00076//PF16367//PF00628//PF14634//PF04574//PF00439//PF00130//PF00536//PF00400//PF00326 U-box domain//Sterile alpha motif (SAM)/Pointed domain//Strabismus protein//Zinc-finger of the MIZ type in Nse subunit//Domain of unknown function (DUF1908)//SAM domain (Sterile alpha motif)//Methyl-CpG binding domain//Zinc-binding domain of primase-helicase//Dynein light chain type 1//Serine carboxypeptidase S28//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//PHD-finger//zinc-RING finger domain//Protein of unknown function (DUF592)//Bromodomain//Phorbol esters/diacylglycerol binding domain (C1 domain)//SAM domain (Sterile alpha motif)//WD domain, G-beta repeat//Prolyl oligopeptidase family GO:0006807//GO:0006476//GO:0006351//GO:0006355//GO:0007017//GO:0006468//GO:0009069//GO:0006508//GO:0007275//GO:0006342//GO:0016310//GO:0016567//GO:0006269//GO:0035556 nitrogen compound metabolic process//protein deacetylation//transcription, DNA-templated//regulation of transcription, DNA-templated//microtubule-based process//protein phosphorylation//serine family amino acid metabolic process//proteolysis//multicellular organismal development//chromatin silencing//phosphorylation//protein ubiquitination//DNA replication, synthesis of RNA primer//intracellular signal transduction GO:0000287//GO:0003677//GO:0004386//GO:0005515//GO:0051287//GO:0043565//GO:0008270//GO:0003896//GO:0016811//GO:0017136//GO:0003676//GO:0004842//GO:0004674//GO:0008236//GO:0005524 magnesium ion binding//DNA binding//helicase activity//protein binding//NAD binding//sequence-specific DNA binding//zinc ion binding//DNA primase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//NAD-dependent histone deacetylase activity//nucleic acid binding//ubiquitin-protein transferase activity//protein serine/threonine kinase activity//serine-type peptidase activity//ATP binding GO:0005657//GO:0005634//GO:0005875//GO:0016021//GO:0000118//GO:0005730 replication fork//nucleus//microtubule associated complex//integral component of membrane//histone deacetylase complex//nucleolus KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.47587 BP_3 962.72 25.11 2140 759056049 XP_011337263.1 1712 4.2e-188 PREDICTED: septin-2 isoform X2 [Cerapachys biroi] 749756922 XM_011142606.1 276 3.60503e-140 PREDICTED: Harpegnathos saltator septin-2 (LOC105184061), mRNA K16939 SEPT6_8_11 septin 6/8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K16939 P54359 1637 8.6e-181 Septin-2 OS=Drosophila melanogaster GN=Sep2 PE=2 SV=2 PF07926//PF04799//PF03193//PF13897//PF00071//PF02601//PF00735//PF08477//PF04111//PF01926//PF10186//PF06367 TPR/MLP1/MLP2-like protein//fzo-like conserved region//Protein of unknown function, DUF258//Golgi-dynamics membrane-trafficking//Ras family//Exonuclease VII, large subunit//Septin//Ras of Complex, Roc, domain of DAPkinase//Autophagy protein Apg6//50S ribosome-binding GTPase//Vacuolar sorting 38 and autophagy-related subunit 14//Diaphanous FH3 Domain GO:0006308//GO:0010508//GO:0007264//GO:0006606//GO:0008053//GO:0006810//GO:0016043//GO:0006914 DNA catabolic process//positive regulation of autophagy//small GTPase mediated signal transduction//protein import into nucleus//mitochondrial fusion//transport//cellular component organization//autophagy GO:0005525//GO:0003924//GO:0003779//GO:0008855 GTP binding//GTPase activity//actin binding//exodeoxyribonuclease VII activity GO:0005741//GO:0009318//GO:0016021 mitochondrial outer membrane//exodeoxyribonuclease VII complex//integral component of membrane KOG3859 Septins (P-loop GTPases) Cluster-8309.47589 BP_3 320.00 18.36 1132 270002223 EEZ98670.1 642 2.6e-64 hypothetical protein TcasGA2_TC001202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UPR3 132 1.5e-06 Protein SMG5 OS=Homo sapiens GN=SMG5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47590 BP_3 424.62 12.65 1909 759056049 XP_011337263.1 1605 9.6e-176 PREDICTED: septin-2 isoform X2 [Cerapachys biroi] 749756922 XM_011142606.1 267 3.2322e-135 PREDICTED: Harpegnathos saltator septin-2 (LOC105184061), mRNA K16939 SEPT6_8_11 septin 6/8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K16939 P54359 1554 3.2e-171 Septin-2 OS=Drosophila melanogaster GN=Sep2 PE=2 SV=2 PF00910//PF00071//PF00735//PF03193//PF08477//PF01926 RNA helicase//Ras family//Septin//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0003724//GO:0003924//GO:0005525//GO:0003723 RNA helicase activity//GTPase activity//GTP binding//RNA binding -- -- KOG3859 Septins (P-loop GTPases) Cluster-8309.47591 BP_3 788.05 13.28 3151 91086463 XP_969857.1 1953 7.0e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1236 4.0e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.47593 BP_3 192.34 1.15 8381 91083409 XP_968752.1 1012 2.4e-106 PREDICTED: sodium/potassium/calcium exchanger 4 [Tribolium castaneum]>gi|270006894|gb|EFA03342.1| hypothetical protein TcasGA2_TC013319 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q8NFF2 545 1.4e-53 Sodium/potassium/calcium exchanger 4 OS=Homo sapiens GN=SLC24A4 PE=1 SV=2 PF06689//PF01699 ClpX C4-type zinc finger//Sodium/calcium exchanger protein GO:0055085 transmembrane transport GO:0046983//GO:0008270 protein dimerization activity//zinc ion binding GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.47594 BP_3 19.58 1.37 982 91083409 XP_968752.1 914 6.6e-96 PREDICTED: sodium/potassium/calcium exchanger 4 [Tribolium castaneum]>gi|270006894|gb|EFA03342.1| hypothetical protein TcasGA2_TC013319 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q8NFF2 567 4.7e-57 Sodium/potassium/calcium exchanger 4 OS=Homo sapiens GN=SLC24A4 PE=1 SV=2 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.47596 BP_3 83.10 0.36 11370 642923391 XP_008193728.1 8407 0.0e+00 PREDICTED: protein still life, isoform SIF type 1 [Tribolium castaneum] 642923390 XM_008195506.1 1824 0 PREDICTED: Tribolium castaneum protein still life, isoform SIF type 1 (LOC662876), mRNA -- -- -- -- P91621 6459 0.0e+00 Protein still life, isoform SIF type 1 OS=Drosophila melanogaster GN=sif PE=2 SV=2 PF05453//PF02196//PF02724//PF13180//PF00621//PF00595 BmTXKS1/BmP02 toxin family//Raf-like Ras-binding domain//CDC45-like protein//PDZ domain//RhoGEF domain//PDZ domain (Also known as DHR or GLGF) GO:0006810//GO:0006270//GO:0007165//GO:0009405//GO:0035023//GO:0043087 transport//DNA replication initiation//signal transduction//pathogenesis//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0008200//GO:0005057//GO:0005089 protein binding//ion channel inhibitor activity//receptor signaling protein activity//Rho guanyl-nucleotide exchange factor activity GO:0005576 extracellular region KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases Cluster-8309.47599 BP_3 108.36 1.90 3047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.476 BP_3 50.02 0.74 3561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47602 BP_3 147.36 1.66 4578 642932649 XP_969929.2 1010 2.3e-106 PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15112 SLC25A27, UCP4 solute carrier family 25 (mitochondrial uncoupling protein), member 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15112 O95847 705 2.2e-72 Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.47603 BP_3 274.59 2.80 5018 642932649 XP_969929.2 1247 8.2e-134 PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15112 SLC25A27, UCP4 solute carrier family 25 (mitochondrial uncoupling protein), member 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15112 O95847 886 2.5e-93 Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.47605 BP_3 240.29 6.83 1987 642921483 XP_008192888.1 1043 1.5e-110 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY1 209 3.1e-15 Monocarboxylate transporter 9 OS=Homo sapiens GN=SLC16A9 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.47607 BP_3 418.32 5.79 3774 91091546 XP_970948.1 1001 2.1e-105 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|642936928|ref|XP_008194494.1| PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270000921|gb|EEZ97368.1| hypothetical protein TcasGA2_TC011190 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96MX3 167 4.4e-10 Zinc finger protein 48 OS=Homo sapiens GN=ZNF48 PE=1 SV=2 PF13912//PF00096//PF02178 C2H2-type zinc finger//Zinc finger, C2H2 type//AT hook motif -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.47608 BP_3 25.89 0.96 1586 91084907 XP_969916.1 693 4.5e-70 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 169 8.03971e-81 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 622 3.2e-63 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF04869 Aldehyde dehydrogenase family//Uso1 / p115 like vesicle tethering protein, head region GO:0009058//GO:0032259//GO:0055114//GO:0048280//GO:0006886//GO:0008152 biosynthetic process//methylation//oxidation-reduction process//vesicle fusion with Golgi apparatus//intracellular protein transport//metabolic process GO:0016620//GO:0016742//GO:0008168//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//hydroxymethyl-, formyl- and related transferase activity//methyltransferase activity//oxidoreductase activity GO:0005737//GO:0000139 cytoplasm//Golgi membrane KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.47609 BP_3 747.07 18.65 2222 642916163 XP_008190912.1 2033 2.6e-225 PREDICTED: abhydrolase domain-containing protein 16A [Tribolium castaneum]>gi|270003703|gb|EFA00151.1| hypothetical protein TcasGA2_TC002972 [Tribolium castaneum] 658893399 XM_008431335.1 63 9.5401e-22 PREDICTED: Poecilia reticulata abhydrolase domain containing 16A (abhd16a), transcript variant X2, mRNA -- -- -- -- Q5R6S0 1171 9.7e-127 Abhydrolase domain-containing protein 16A OS=Pongo abelii GN=ABHD16A PE=2 SV=1 PF00326 Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- KOG1553 Predicted alpha/beta hydrolase BAT5 Cluster-8309.4761 BP_3 2.50 0.58 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47611 BP_3 298.20 7.11 2312 189235087 XP_001808767.1 2027 1.4e-224 PREDICTED: leucine-rich repeat-containing protein 16A [Tribolium castaneum] 642915512 XM_008192426.1 123 4.39795e-55 PREDICTED: Tribolium castaneum adenylate kinase isoenzyme 6 (LOC103312254), mRNA -- -- -- -- Q5VZK9 887 8.7e-94 Leucine-rich repeat-containing protein 16A OS=Homo sapiens GN=LRRC16A PE=1 SV=1 PF01121//PF00560//PF00005//PF03193//PF03266//PF00910//PF10662//PF00493//PF13516//PF01443//PF14532//PF02224//PF01580//PF01926//PF00158//PF01695//PF07728//PF00004//PF13855 Dephospho-CoA kinase//Leucine Rich Repeat//ABC transporter//Protein of unknown function, DUF258//NTPase//RNA helicase//Ethanolamine utilisation - propanediol utilisation//MCM2/3/5 family//Leucine Rich repeat//Viral (Superfamily 1) RNA helicase//Sigma-54 interaction domain//Cytidylate kinase//FtsK/SpoIIIE family//50S ribosome-binding GTPase//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Leucine rich repeat GO:0015937//GO:0006260//GO:0006355//GO:0006139//GO:0015940//GO:0006206//GO:0006576 coenzyme A biosynthetic process//DNA replication//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process//pantothenate biosynthetic process//pyrimidine nucleobase metabolic process//cellular biogenic amine metabolic process GO:0004127//GO:0016887//GO:0000166//GO:0008134//GO:0003924//GO:0098519//GO:0005524//GO:0003724//GO:0004140//GO:0005525//GO:0005515//GO:0003677//GO:0003723 cytidylate kinase activity//ATPase activity//nucleotide binding//transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//RNA helicase activity//dephospho-CoA kinase activity//GTP binding//protein binding//DNA binding//RNA binding GO:0005667 transcription factor complex KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response Cluster-8309.47614 BP_3 66.44 1.50 2424 91081067 XP_975439.1 1963 3.8e-217 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q50L44 311 5.6e-27 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF00560//PF13855//PF13895 Leucine Rich Repeat//Leucine rich repeat//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47618 BP_3 981.67 8.91 5605 642917541 XP_008191247.1 5924 0.0e+00 PREDICTED: protein TANC2 isoform X3 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.12989e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.0e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF13414//PF02376//PF13639//PF00023//PF01637//PF00004//PF00097//PF07728//PF13606 TPR repeat//CUT domain//Ring finger domain//Ankyrin repeat//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//Zinc finger, C3HC4 type (RING finger)//AAA domain (dynein-related subfamily)//Ankyrin repeat -- -- GO:0046872//GO:0005515//GO:0016887//GO:0003677//GO:0008270//GO:0005524 metal ion binding//protein binding//ATPase activity//DNA binding//zinc ion binding//ATP binding -- -- -- -- Cluster-8309.4762 BP_3 11.50 0.35 1853 641649782 XP_003240718.2 932 1.0e-97 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- D2EAC2 299 1.1e-25 Zinc finger BED domain-containing protein 6 OS=Mus musculus GN=Zbed6 PE=1 SV=1 PF05699//PF14372 hAT family C-terminal dimerisation region//Domain of unknown function (DUF4413) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.47620 BP_3 192.73 3.10 3286 332375725 AEE63003.1 548 6.1e-53 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0007178//GO:0016310//GO:0009069//GO:1903818//GO:0030431//GO:0032222 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic GO:0034235//GO:0004675 GPI anchor binding//transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.47622 BP_3 4.00 0.36 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47623 BP_3 1.00 24.86 221 642917002 XP_008199590.1 361 2.0e-32 PREDICTED: E3 ubiquitin-protein ligase RNF216-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 Q9NWF9 235 3.3e-19 E3 ubiquitin-protein ligase RNF216 OS=Homo sapiens GN=RNF216 PE=1 SV=3 PF00098 Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.47624 BP_3 56.46 0.86 3438 642917000 XP_008199589.1 241 2.5e-17 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47625 BP_3 24.38 0.53 2497 642917000 XP_008199589.1 363 1.3e-31 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 165 4.9e-10 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF03119//PF08050 NAD-dependent DNA ligase C4 zinc finger domain//Tetracycline resistance leader peptide GO:0046677//GO:0006260//GO:0006281 response to antibiotic//DNA replication//DNA repair GO:0003911 DNA ligase (NAD+) activity -- -- -- -- Cluster-8309.47627 BP_3 93.03 1.43 3427 642917000 XP_008199589.1 241 2.5e-17 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47628 BP_3 151.62 3.63 2303 642917000 XP_008199589.1 631 1.0e-62 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 252 3.7e-20 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47630 BP_3 141.97 2.39 3156 189237912 XP_969631.2 2893 0.0e+00 PREDICTED: histone acetyltransferase KAT2A [Tribolium castaneum]>gi|270008022|gb|EFA04470.1| hypothetical protein TcasGA2_TC014774 [Tribolium castaneum] -- -- -- -- -- K06062 PCAF, KAT2, GCN5 histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06062 Q9JHD2 1837 8.2e-204 Histone acetyltransferase KAT2A OS=Mus musculus GN=Kat2a PE=1 SV=2 PF13673//PF00583//PF06472//PF13508//PF00439//PF06466 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//ABC transporter transmembrane region 2//Acetyltransferase (GNAT) domain//Bromodomain//PCAF (P300/CBP-associated factor) N-terminal domain GO:0016573//GO:0055085//GO:0042967//GO:0006810//GO:0006355 histone acetylation//transmembrane transport//acyl-carrier-protein biosynthetic process//transport//regulation of transcription, DNA-templated GO:0005524//GO:0008080//GO:0004402//GO:0005515//GO:0042626 ATP binding//N-acetyltransferase activity//histone acetyltransferase activity//protein binding//ATPase activity, coupled to transmembrane movement of substances GO:0005634//GO:0016021//GO:0000123 nucleus//integral component of membrane//histone acetyltransferase complex KOG1472 Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins Cluster-8309.47633 BP_3 97.00 5.78 1100 91091038 XP_975208.1 276 7.1e-22 PREDICTED: uncharacterized protein LOC664098 [Tribolium castaneum]>gi|270013164|gb|EFA09612.1| hypothetical protein TcasGA2_TC011733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03846//PF04442 Cell division inhibitor SulA//Cytochrome c oxidase assembly protein CtaG/Cox11 GO:0009432//GO:0051782 SOS response//negative regulation of cell division GO:0005507 copper ion binding GO:0009276 Gram-negative-bacterium-type cell wall -- -- Cluster-8309.47635 BP_3 729.45 23.54 1785 642913859 XP_008201191.1 617 3.3e-61 PREDICTED: uncharacterized protein LOC103315111 [Tribolium castaneum] 746845580 XM_011054780.1 39 1.67598e-08 PREDICTED: Acromyrmex echinatior protein spaetzle (LOC105145317), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47636 BP_3 65.56 0.41 7971 642918330 XP_008199110.1 4061 0.0e+00 PREDICTED: tyrosine-protein kinase Abl [Tribolium castaneum] 815766251 XM_012363285.1 447 0 PREDICTED: Linepithema humile tyrosine-protein kinase Abl (LOC105670007), mRNA K06619 ABL1 abelson tyrosine-protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06619 P00522 2688 4.3e-302 Tyrosine-protein kinase Abl OS=Drosophila melanogaster GN=Abl PE=1 SV=3 PF07714//PF00018//PF14604//PF00069//PF08919 Protein tyrosine kinase//SH3 domain//Variant SH3 domain//Protein kinase domain//F-actin binding GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0004715 protein binding//protein kinase activity//ATP binding//non-membrane spanning protein tyrosine kinase activity -- -- KOG4278 Protein tyrosine kinase Cluster-8309.47638 BP_3 18.16 0.89 1278 91081755 XP_972918.1 212 2.2e-14 PREDICTED: translation initiation factor eIF-2B subunit epsilon isoform X1 [Tribolium castaneum]>gi|270006269|gb|EFA02717.1| hypothetical protein TcasGA2_TC008441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64350 140 2.0e-07 Translation initiation factor eIF-2B subunit epsilon OS=Rattus norvegicus GN=Eif2b5 PE=1 SV=2 PF02020//PF00435 eIF4-gamma/eIF5/eIF2-epsilon//Spectrin repeat GO:0016070 RNA metabolic process GO:0016740//GO:0005515 transferase activity//protein binding -- -- -- -- Cluster-8309.47639 BP_3 17.00 0.90 1200 642923192 XP_008193649.1 667 3.5e-67 PREDICTED: MFS-type transporter SLC18B1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3Z5L6 293 3.4e-25 MFS-type transporter SLC18B1 OS=Mus musculus GN=Slc18b1 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47640 BP_3 161.46 1.83 4544 642922737 XP_008193304.1 1814 1.3e-199 PREDICTED: protein RRP5 homolog [Tribolium castaneum] -- -- -- -- -- K14792 RRP5, PDCD11 rRNA biogenesis protein RRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K14792 Q14690 642 4.4e-65 Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3 PF00575//PF05843//PF01496 S1 RNA binding domain//Suppressor of forked protein (Suf)//V-type ATPase 116kDa subunit family GO:0006397//GO:0015991//GO:0015992 mRNA processing//ATP hydrolysis coupled proton transport//proton transport GO:0015078//GO:0003676 hydrogen ion transmembrane transporter activity//nucleic acid binding GO:0005634//GO:0033179 nucleus//proton-transporting V-type ATPase, V0 domain KOG1070 rRNA processing protein Rrp5 Cluster-8309.47642 BP_3 94.39 1.56 3202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47644 BP_3 63.77 1.30 2665 546684067 ERL93790.1 2182 1.7e-242 hypothetical protein D910_11076 [Dendroctonus ponderosae] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 1363 6.4e-149 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.47645 BP_3 3.00 0.32 741 91080563 XP_973259.1 262 2.0e-20 PREDICTED: alpha-N-acetylglucosaminidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 152 4.7e-09 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.47646 BP_3 4.32 0.43 771 91090686 XP_974615.1 180 6.7e-11 PREDICTED: FGGY carbohydrate kinase domain-containing protein [Tribolium castaneum]>gi|270013302|gb|EFA09750.1| hypothetical protein TcasGA2_TC011889 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCD1 147 1.9e-08 FGGY carbohydrate kinase domain-containing protein OS=Xenopus laevis GN=fggy PE=2 SV=2 PF00370 FGGY family of carbohydrate kinases, N-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.47648 BP_3 172.15 1.10 7838 642920114 XP_008192211.1 1223 7.8e-131 PREDICTED: E3 ubiquitin-protein ligase SH3RF1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.6e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF13639//PF14634//PF09360//PF17123//PF00097//PF00018//PF14604 Ring finger domain//zinc-RING finger domain//Iron-binding zinc finger CDGSH type//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger)//SH3 domain//Variant SH3 domain -- -- GO:0008270//GO:0051537//GO:0005515//GO:0046872 zinc ion binding//2 iron, 2 sulfur cluster binding//protein binding//metal ion binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.47650 BP_3 77.09 0.49 7822 817087620 XP_012266596.1 1741 6.7e-191 PREDICTED: uncharacterized protein LOC105692156 isoform X1 [Athalia rosae] 780665329 XM_011695591.1 124 4.17808e-55 PREDICTED: Wasmannia auropunctata uncharacterized LOC105453540 (LOC105453540), mRNA -- -- -- -- Q3ZCX4 649 1.2e-65 Zinc finger protein 568 OS=Homo sapiens GN=ZNF568 PE=2 SV=2 PF08064//PF13465//PF08880//PF00096 UME (NUC010) domain//Zinc-finger double domain//QLQ//Zinc finger, C2H2 type GO:0006355//GO:0016310//GO:0009069 regulation of transcription, DNA-templated//phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0046872 ATP binding//protein serine/threonine kinase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.47652 BP_3 876.11 16.04 2924 189237332 XP_973384.2 1523 4.8e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 9.73578e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.4e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.47653 BP_3 200.78 1.94 5272 642934658 XP_008197755.1 4283 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.06987e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 531 3.8e-52 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF08727//PF01702//PF00595 Poliovirus 3A protein like//Queuine tRNA-ribosyltransferase//PDZ domain (Also known as DHR or GLGF) GO:0008616//GO:0006144//GO:0006508//GO:0006400 queuosine biosynthetic process//purine nucleobase metabolic process//proteolysis//tRNA modification GO:0008479//GO:0005515//GO:0003968//GO:0004197//GO:0017111 queuine tRNA-ribosyltransferase activity//protein binding//RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.47656 BP_3 118.53 1.16 5197 642938278 XP_008192712.1 3280 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 959 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.1e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF07714//PF00069//PF12142 Protein tyrosine kinase//Protein kinase domain//Polyphenol oxidase middle domain GO:0006570//GO:0006468//GO:0055114//GO:0006118 tyrosine metabolic process//protein phosphorylation//oxidation-reduction process//obsolete electron transport GO:0004097//GO:0004672//GO:0005524 catechol oxidase activity//protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.47657 BP_3 235.78 2.92 4185 642938278 XP_008192712.1 3056 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 871 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 Q9UKI8 1731 2.1e-191 Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens GN=TLK1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.47659 BP_3 218.95 1.36 8037 -- -- -- -- -- 642938285 XM_008194514.1 89 1.22801e-35 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF09477 Bacterial type II secretion system chaperone protein (type_III_yscG) GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.47660 BP_3 84.66 0.98 4437 642933795 XP_008197323.1 2058 6.6e-228 PREDICTED: multidrug resistance-associated protein 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q5F364 1283 2.0e-139 Multidrug resistance-associated protein 1 OS=Gallus gallus GN=ABCC1 PE=2 SV=1 PF03193//PF00005//PF17001//PF09547//PF06414//PF01637//PF08603//PF13304//PF01926//PF00664 Protein of unknown function, DUF258//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Stage IV sporulation protein A (spore_IV_A)//Zeta toxin//Archaeal ATPase//Adenylate cyclase associated (CAP) C terminal//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region GO:0009306//GO:0006810//GO:0007010//GO:0055085//GO:0043934 protein secretion//transport//cytoskeleton organization//transmembrane transport//sporulation GO:0003924//GO:0003779//GO:0005524//GO:0042626//GO:0005525//GO:0016887//GO:0016301 GTPase activity//actin binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47662 BP_3 25.29 0.32 4089 91080503 XP_971456.1 546 1.3e-52 PREDICTED: fasciclin-2 [Tribolium castaneum]>gi|642919288|ref|XP_008191811.1| PREDICTED: fasciclin-2 [Tribolium castaneum]>gi|642919290|ref|XP_008191812.1| PREDICTED: fasciclin-2 [Tribolium castaneum]>gi|270005773|gb|EFA02221.1| hypothetical protein TcasGA2_TC007882 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35136 179 1.9e-11 Neural cell adhesion molecule 2 OS=Mus musculus GN=Ncam2 PE=2 SV=1 PF02300//PF13895//PF00041 Fumarate reductase subunit C//Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.47664 BP_3 264.00 34.83 657 -- -- -- -- -- 642937526 XM_008200861.1 81 2.6803e-32 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X7, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47665 BP_3 80.00 3.39 1429 570341954 AHE77375.1 542 1.3e-52 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 340 1.4e-30 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525 Alpha crystallin A chain, N terminal GO:0007423 sensory organ development GO:0005212 structural constituent of eye lens -- -- -- -- Cluster-8309.47666 BP_3 906.77 8.91 5196 189233955 XP_967484.2 2432 3.3e-271 PREDICTED: uncharacterized protein LOC655828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-8309.47668 BP_3 36.21 0.53 3567 815897996 XP_012249713.1 1473 3.6e-160 PREDICTED: histone deacetylase 6 [Bombus impatiens] -- -- -- -- -- K11407 HDAC6 histone deacetylase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11407 Q9Z2V5 1042 1.4e-111 Histone deacetylase 6 OS=Mus musculus GN=Hdac6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.47671 BP_3 92.18 0.97 4858 91089275 XP_970398.1 2665 3.0e-298 PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase 9 isoform X1 [Tribolium castaneum] 642933027 XM_965305.2 493 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 2186 4.3e-244 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.47672 BP_3 1254.75 27.60 2483 642926071 XP_008194753.1 2757 3.3e-309 PREDICTED: transcription elongation factor SPT5 [Tribolium castaneum]>gi|270008998|gb|EFA05446.1| hypothetical protein TcasGA2_TC015626 [Tribolium castaneum] 158293810 XM_001231044.2 314 3.15053e-161 Anopheles gambiae str. PEST AGAP005021-PA (AgaP_AGAP005021) mRNA, complete cds K15172 SUPT5H, SPT5 transcription elongation factor SPT5 http://www.genome.jp/dbget-bin/www_bget?ko:K15172 Q9V460 2232 1.0e-249 Transcription elongation factor SPT5 OS=Drosophila melanogaster GN=Spt5 PE=1 SV=1 -- -- GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter -- -- -- -- KOG1999 RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5 Cluster-8309.47674 BP_3 10.11 1.28 671 189237923 XP_001810409.1 541 8.1e-53 PREDICTED: exocyst complex component 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U247 249 2.4e-20 Exocyst complex component 8 OS=Xenopus laevis GN=exoc8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47676 BP_3 130.49 1.10 5998 546680189 ERL90517.1 1703 1.3e-186 hypothetical protein D910_07865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 523 3.6e-51 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF05440 Tetrahydromethanopterin S-methyltransferase subunit B GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47678 BP_3 130.02 4.70 1624 642912091 XP_008200799.1 1091 3.3e-116 PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912093|ref|XP_008200800.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912095|ref|XP_008200802.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47679 BP_3 9.45 1.06 722 642912738 XP_966526.2 300 7.6e-25 PREDICTED: uncharacterized protein LOC654964 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 234 1.4e-18 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF02798//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.4768 BP_3 1.00 0.51 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47680 BP_3 628.00 8.15 4008 189238846 XP_971101.2 2032 6.2e-225 PREDICTED: XK-related protein 7 [Tribolium castaneum]>gi|270010171|gb|EFA06619.1| hypothetical protein TcasGA2_TC009537 [Tribolium castaneum] -- -- -- -- -- K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q803V3 1320 9.3e-144 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Danio rerio GN=ppp2r3c PE=2 SV=1 PF09815//PF13499//PF00036//PF13405 XK-related protein//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding GO:0016021 integral component of membrane KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.47684 BP_3 1125.83 12.23 4727 478260301 ENN80053.1 3354 0.0e+00 hypothetical protein YQE_03529, partial [Dendroctonus ponderosae] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 1901 4.7e-211 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 PF04851//PF04408//PF02562//PF00437//PF00270//PF07652 Type III restriction enzyme, res subunit//Helicase associated domain (HA2)//PhoH-like protein//Type II/IV secretion system protein//DEAD/DEAH box helicase//Flavivirus DEAD domain GO:0006810//GO:0019079 transport//viral genome replication GO:0008026//GO:0004386//GO:0005524//GO:0003677//GO:0016787//GO:0003676 ATP-dependent helicase activity//helicase activity//ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.47685 BP_3 98.42 0.82 6065 478260301 ENN80053.1 2656 4.1e-297 hypothetical protein YQE_03529, partial [Dendroctonus ponderosae] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 1477 8.7e-162 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 PF00437//PF07652//PF00270//PF04408//PF02562//PF04851 Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase//Helicase associated domain (HA2)//PhoH-like protein//Type III restriction enzyme, res subunit GO:0019079//GO:0006810 viral genome replication//transport GO:0016787//GO:0003677//GO:0004386//GO:0005524//GO:0008026//GO:0003676 hydrolase activity//DNA binding//helicase activity//ATP binding//ATP-dependent helicase activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.47688 BP_3 61.99 0.91 3565 546680054 ERL90409.1 2899 0.0e+00 hypothetical protein D910_07758, partial [Dendroctonus ponderosae] -- -- -- -- -- K13146 INTS9 integrator complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13146 Q8K114 1741 1.3e-192 Integrator complex subunit 9 OS=Mus musculus GN=Ints9 PE=2 SV=1 PF01896//PF00076 Eukaryotic and archaeal DNA primase small subunit//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896//GO:0003676 DNA primase activity//nucleic acid binding GO:0005730//GO:0005657 nucleolus//replication fork KOG1138 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.47689 BP_3 81.30 1.20 3563 546680054 ERL90409.1 2571 1.7e-287 hypothetical protein D910_07758, partial [Dendroctonus ponderosae] -- -- -- -- -- K13146 INTS9 integrator complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13146 Q6DFF4 1564 4.2e-172 Integrator complex subunit 9 OS=Xenopus laevis GN=ints9 PE=2 SV=1 PF00076//PF01896//PF00665 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Eukaryotic and archaeal DNA primase small subunit//Integrase core domain GO:0006351//GO:0006269//GO:0015074 transcription, DNA-templated//DNA replication, synthesis of RNA primer//DNA integration GO:0003676//GO:0003896 nucleic acid binding//DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG1138 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.4769 BP_3 21.62 0.94 1395 91076370 XP_967715.1 286 6.2e-23 PREDICTED: ras-related protein Rab-27A [Tribolium castaneum]>gi|270002552|gb|EEZ98999.1| hypothetical protein TcasGA2_TC004860 [Tribolium castaneum] -- -- -- -- -- K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 P23640 185 1.3e-12 Ras-related protein Rab-27A OS=Rattus norvegicus GN=Rab27a PE=1 SV=1 PF00071 Ras family GO:0015031//GO:0007264 protein transport//small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0081 GTPase Rab27, small G protein superfamily Cluster-8309.47691 BP_3 94.00 0.62 7550 270003693 EFA00141.1 4947 0.0e+00 hypothetical protein TcasGA2_TC002962 [Tribolium castaneum] 642915996 XM_008192627.1 748 0 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA -- -- -- -- O01761 501 1.6e-48 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF02474//PF02554//PF01184 Immunoglobulin domain//Nodulation protein A (NodA)//Carbon starvation protein CstA//GPR1/FUN34/yaaH family GO:0009267//GO:0009877 cellular response to starvation//nodulation GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0005829//GO:0016021//GO:0016020 cytosol//integral component of membrane//membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.47695 BP_3 1.10 0.31 459 642910375 XP_008200297.1 190 2.8e-12 PREDICTED: uncharacterized protein LOC660207 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47697 BP_3 41.65 0.32 6642 478250040 ENN70546.1 5690 0.0e+00 hypothetical protein YQE_12721, partial [Dendroctonus ponderosae] 194747504 XM_001956156.1 230 4.21226e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q0V8T7 600 4.7e-60 Contactin-associated protein like 5-3 OS=Mus musculus GN=Cntnap5c PE=2 SV=1 PF00008//PF10192 EGF-like domain//Rhodopsin-like GPCR transmembrane domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0005515 protein binding -- -- -- -- Cluster-8309.47699 BP_3 1346.00 26.98 2696 -- -- -- -- -- 642928667 XM_008201507.1 93 2.44085e-38 PREDICTED: Tribolium castaneum protein daughterless (LOC662057), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.477 BP_3 2.00 0.31 599 546675827 ERL86932.1 176 1.5e-10 hypothetical protein D910_04335 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4770 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47701 BP_3 421.05 6.94 3217 642935257 XP_008197935.1 595 2.1e-58 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q99808 205 1.5e-14 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF01733//PF04893 Nucleoside transporter//Yip1 domain GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.47702 BP_3 264.98 12.90 1282 642935257 XP_008197935.1 1324 2.5e-143 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 372 2.5e-34 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.47703 BP_3 152.50 2.49 3243 642935257 XP_008197935.1 595 2.1e-58 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q99808 205 1.5e-14 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF01733//PF04893 Nucleoside transporter//Yip1 domain GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.47704 BP_3 131.42 5.04 1549 642935257 XP_008197935.1 776 1.0e-79 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q9BZD2 258 5.0e-21 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF03600//PF01733 Citrate transporter//Nucleoside transporter GO:0055085//GO:0015858//GO:0006810 transmembrane transport//nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.47706 BP_3 119.00 6.87 1127 642911168 XP_008200609.1 488 1.9e-46 PREDICTED: leucine-rich repeat-containing protein 70-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 199 2.5e-14 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47712 BP_3 1059.75 9.98 5412 189238580 XP_971286.2 2127 8.1e-236 PREDICTED: protein mothers against dpp-like [Tribolium castaneum] 826414663 XM_012666571.1 155 1.68853e-72 PREDICTED: Monomorium pharaonis protein mothers against dpp (LOC105828307), transcript variant X2, mRNA K04676 SMAD1 mothers against decapentaplegic homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04676 P42003 1912 2.8e-212 Protein mothers against dpp OS=Drosophila melanogaster GN=Mad PE=1 SV=1 PF01272//PF03165//PF10401//PF03166 Transcription elongation factor, GreA/GreB, C-term//MH1 domain//Interferon-regulatory factor 3//MH2 domain GO:0006355//GO:0032784 regulation of transcription, DNA-templated//regulation of DNA-templated transcription, elongation GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.47713 BP_3 48.56 0.51 4837 91084075 XP_967986.1 1341 1.0e-144 PREDICTED: regucalcin [Tribolium castaneum]>gi|270006685|gb|EFA03133.1| hypothetical protein TcasGA2_TC013045 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I923 524 2.2e-51 Regucalcin OS=Gallus gallus GN=RGN PE=2 SV=1 -- -- GO:0050790 regulation of catalytic activity GO:0030234//GO:0005509 enzyme regulator activity//calcium ion binding -- -- -- -- Cluster-8309.47714 BP_3 51.02 0.88 3082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01853 MOZ/SAS family GO:0006355 regulation of transcription, DNA-templated GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.47716 BP_3 13.55 1.05 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47717 BP_3 169.97 3.00 3022 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01853//PF05428 MOZ/SAS family//Corticotropin-releasing factor binding protein (CRF-BP) GO:0006355 regulation of transcription, DNA-templated GO:0016747//GO:0051424 transferase activity, transferring acyl groups other than amino-acyl groups//corticotropin-releasing hormone binding -- -- -- -- Cluster-8309.47718 BP_3 671.83 4.73 7132 91087949 XP_972541.1 1210 2.3e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.1e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF12763//PF13606//PF13405//PF10591//PF13833//PF13499//PF13202//PF01694//PF00036//PF00023 Cytoskeletal-regulatory complex EF hand//Ankyrin repeat//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain pair//EF hand//Rhomboid family//EF hand//Ankyrin repeat GO:0007165 signal transduction GO:0005509//GO:0004252//GO:0005515 calcium ion binding//serine-type endopeptidase activity//protein binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.47719 BP_3 227.49 1.65 6939 91087949 XP_972541.1 1210 2.2e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.1e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF13606//PF13833//PF10591//PF13405//PF13499//PF12763//PF00036//PF00023//PF13202//PF01694 Ankyrin repeat//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//EF hand//Ankyrin repeat//EF hand//Rhomboid family GO:0007165 signal transduction GO:0004252//GO:0005515//GO:0005509 serine-type endopeptidase activity//protein binding//calcium ion binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.4772 BP_3 4.59 0.59 669 270004758 EFA01206.1 190 4.0e-12 hypothetical protein TcasGA2_TC010533 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15050//PF00060 SCIMP protein//Ligand-gated ion channel GO:0006811//GO:0007165//GO:0007268 ion transport//signal transduction//synaptic transmission GO:0004970 ionotropic glutamate receptor activity GO:0016020//GO:0016021//GO:0001772//GO:0097197 membrane//integral component of membrane//immunological synapse//tetraspanin-enriched microdomain -- -- Cluster-8309.47720 BP_3 26.99 0.41 3476 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.6e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47721 BP_3 157.66 0.60 13012 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 800 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.3e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF01436//PF01017//PF03124//PF06743//PF00097//PF14634//PF00643 NHL repeat//STAT protein, all-alpha domain//EXS family//FAST kinase-like protein, subdomain 1//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//B-box zinc finger GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0008270//GO:0004871//GO:0003700//GO:0004672//GO:0046872//GO:0005515 zinc ion binding//signal transducer activity//transcription factor activity, sequence-specific DNA binding//protein kinase activity//metal ion binding//protein binding GO:0005622//GO:0016021//GO:0005667 intracellular//integral component of membrane//transcription factor complex KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.47723 BP_3 43.58 13.75 444 91077988 XP_968808.1 167 1.2e-09 PREDICTED: protein SERAC1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47726 BP_3 12.93 1.18 821 91093771 XP_966673.1 245 2.1e-18 PREDICTED: histone acetyltransferase type B catalytic subunit [Tribolium castaneum]>gi|270015923|gb|EFA12371.1| hypothetical protein TcasGA2_TC002077 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47727 BP_3 424.08 2.70 7876 91093773 XP_966763.1 1569 5.9e-171 PREDICTED: KAT8 regulatory NSL complex subunit 1 [Tribolium castaneum]>gi|270015922|gb|EFA12370.1| hypothetical protein TcasGA2_TC002076 [Tribolium castaneum] 462418059 APGK01017125.1 89 1.20329e-35 Dendroctonus ponderosae Seq01017135, whole genome shotgun sequence K18400 KANSL1 KAT8 regulatory NSL complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18400 Q7Z3B3 343 3.6e-30 KAT8 regulatory NSL complex subunit 1 OS=Homo sapiens GN=KANSL1 PE=1 SV=2 PF06009//PF14822//PF08651//PF17064 Laminin Domain II//Vasohibin//DASH complex subunit Duo1//Sleepless protein GO:0032222//GO:0007155//GO:0007067//GO:0045765//GO:0030431//GO:1903818 regulation of synaptic transmission, cholinergic//cell adhesion//mitotic nuclear division//regulation of angiogenesis//sleep//positive regulation of voltage-gated potassium channel activity GO:0034235 GPI anchor binding GO:0042729//GO:0005737//GO:0072686 DASH complex//cytoplasm//mitotic spindle -- -- Cluster-8309.47729 BP_3 255.07 12.40 1283 478252069 ENN72500.1 875 2.9e-91 hypothetical protein YQE_10841, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O14929 434 1.6e-41 Histone acetyltransferase type B catalytic subunit OS=Homo sapiens GN=HAT1 PE=1 SV=1 PF10394//PF06580//PF13508//PF05301//PF00583//PF13673//PF08445 Histone acetyl transferase HAT1 N-terminus//Histidine kinase//Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967//GO:0016310//GO:0016568//GO:0000160//GO:0071929 acyl-carrier-protein biosynthetic process//phosphorylation//chromatin modification//phosphorelay signal transduction system//alpha-tubulin acetylation GO:0008080//GO:0004402//GO:0000155//GO:0016747//GO:0019799 N-acetyltransferase activity//histone acetyltransferase activity//phosphorelay sensor kinase activity//transferase activity, transferring acyl groups other than amino-acyl groups//tubulin N-acetyltransferase activity GO:0005874//GO:0009365//GO:0045298//GO:0016021//GO:0000123 microtubule//protein histidine kinase complex//tubulin complex//integral component of membrane//histone acetyltransferase complex KOG2696 Histone acetyltransferase type b catalytic subunit Cluster-8309.4773 BP_3 5.42 0.72 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05336 Domain of unknown function (DUF718) GO:0019299 rhamnose metabolic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0005737 cytoplasm -- -- Cluster-8309.47730 BP_3 180.51 4.64 2165 478259245 ENN79147.1 730 3.2e-74 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR0 414 5.7e-39 Kelch domain-containing protein 10 OS=Mus musculus GN=Klhdc10 PE=1 SV=1 PF01344//PF09187//PF00892//PF07646//PF05720 Kelch motif//Domain of unknown function(DUF1950)//EamA-like transporter family//Kelch motif//Cell-cell adhesion domain GO:0007155//GO:0044030 cell adhesion//regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0005634//GO:0016021 membrane//nucleus//integral component of membrane -- -- Cluster-8309.47732 BP_3 59.29 3.35 1144 642927612 XP_973436.3 625 2.5e-62 PREDICTED: cell growth regulator with RING finger domain protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47733 BP_3 2042.11 22.49 4669 283046724 NP_001164308.1 1952 1.4e-215 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 751 1.0e-77 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF00520//PF08727//PF13606//PF00023 Ion transport protein//Poliovirus 3A protein like//Ankyrin repeat//Ankyrin repeat GO:0055085//GO:0006144//GO:0006508//GO:0006811 transmembrane transport//purine nucleobase metabolic process//proteolysis//ion transport GO:0005515//GO:0005216//GO:0003968//GO:0004197//GO:0017111 protein binding//ion channel activity//RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity GO:0016020//GO:0031379 membrane//RNA-directed RNA polymerase complex -- -- Cluster-8309.47734 BP_3 193.18 1.40 6958 642935550 XP_008198055.1 345 4.5e-29 PREDICTED: toxin S6C6 [Tribolium castaneum] -- -- -- -- -- K04008 CD59 CD59 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K04008 -- -- -- -- PF01051//PF00087 Initiator Replication protein//Snake toxin GO:0006270//GO:0009405//GO:0006260 DNA replication initiation//pathogenesis//DNA replication GO:0003887 DNA-directed DNA polymerase activity GO:0042575//GO:0005727//GO:0005576 DNA polymerase complex//extrachromosomal circular DNA//extracellular region -- -- Cluster-8309.47737 BP_3 48.60 1.58 1778 642915807 XP_008200086.1 1110 2.2e-118 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 817218728 XM_012429755.1 250 8.47762e-126 PREDICTED: Orussus abietinus WD repeat-containing protein 47-like (LOC105702288), partial mRNA -- -- -- -- Q8CGF6 571 2.9e-57 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47738 BP_3 49.67 4.19 863 546684237 ERL93942.1 407 3.6e-37 hypothetical protein D910_11228 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02703 Early E1A protein GO:0019048//GO:0006355 modulation by virus of host morphology or physiology//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.47739 BP_3 30.68 0.46 3524 478254650 ENN74891.1 1311 2.2e-141 hypothetical protein YQE_08470, partial [Dendroctonus ponderosae] 195480065 XM_002101088.1 119 1.12698e-52 Drosophila yakuba GE15793 (Dyak\GE15793), partial mRNA -- -- -- -- -- -- -- -- PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.4774 BP_3 5.86 0.34 1127 642922863 XP_008200428.1 586 8.2e-58 PREDICTED: uncharacterized protein LOC103314915 [Tribolium castaneum] -- -- -- -- -- K05326 CNGN cyclic nucleotide gated channel, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05326 -- -- -- -- PF10458 Valyl tRNA synthetase tRNA binding arm GO:0009099//GO:0009098//GO:0006438//GO:0009097 valine biosynthetic process//leucine biosynthetic process//valyl-tRNA aminoacylation//isoleucine biosynthetic process GO:0000166//GO:0004832//GO:0005524 nucleotide binding//valine-tRNA ligase activity//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.47740 BP_3 163.10 1.90 4430 642937338 XP_008198794.1 871 2.9e-90 PREDICTED: innexin inx7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3W6 554 6.8e-55 Innexin inx7 OS=Drosophila melanogaster GN=Inx7 PE=2 SV=1 PF00876//PF05274 Innexin//Occlusion-derived virus envelope protein E25 -- -- -- -- GO:0019031//GO:0005921//GO:0042025 viral envelope//gap junction//host cell nucleus -- -- Cluster-8309.47742 BP_3 31.86 0.53 3202 478252320 ENN72746.1 975 1.8e-102 hypothetical protein YQE_10551, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7T3C7 310 9.7e-27 Reticulon-4-interacting protein 1 homolog, mitochondrial OS=Danio rerio GN=rtn4ip1 PE=2 SV=2 PF08102 Scorpion antimicrobial peptide -- -- -- -- GO:0005576 extracellular region KOG1198 Zinc-binding oxidoreductase Cluster-8309.47751 BP_3 1721.13 54.57 1812 189235224 XP_967725.2 2213 2.9e-246 PREDICTED: coatomer subunit delta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 1501 4.3e-165 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.47753 BP_3 276.08 3.77 3818 607360166 EZA54504.1 144 5.0e-06 hypothetical protein X777_05483 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47754 BP_3 57.20 0.72 4101 642919579 XP_008191929.1 2776 3.2e-311 PREDICTED: heat shock 70 kDa protein 4 isoform X2 [Tribolium castaneum]>gi|270005857|gb|EFA02305.1| hypothetical protein TcasGA2_TC007971 [Tribolium castaneum] -- -- -- -- -- K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q61316 1784 1.5e-197 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 PF06723//PF04355 MreB/Mbl protein//SmpA / OmlA family GO:0000902 cell morphogenesis GO:0005524 ATP binding GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.47758 BP_3 80.45 0.53 7639 91092226 XP_970548.1 4648 0.0e+00 PREDICTED: plexin-A2 [Tribolium castaneum]>gi|642912031|ref|XP_008199067.1| PREDICTED: plexin-A2 [Tribolium castaneum]>gi|270015104|gb|EFA11552.1| plexin A [Tribolium castaneum] 665792256 XM_008545501.1 519 0 PREDICTED: Microplitis demolitor plexin-A4 (LOC103568572), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 Q9HCM2 2278 1.4e-254 Plexin-A4 OS=Homo sapiens GN=PLXNA4 PE=1 SV=4 PF01403//PF01437//PF01833 Sema domain//Plexin repeat//IPT/TIG domain GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0004872//GO:0005515 receptor activity//protein binding GO:0005622//GO:0016020//GO:0016021 intracellular//membrane//integral component of membrane KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.47759 BP_3 22.81 0.39 3078 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09003 Bacteriophage lambda integrase, N-terminal domain GO:0015074 DNA integration GO:0003677//GO:0008907 DNA binding//integrase activity -- -- -- -- Cluster-8309.47760 BP_3 91.41 0.96 4894 642917076 XP_967651.3 1148 2.4e-122 PREDICTED: GTP-binding protein Di-Ras1 [Tribolium castaneum]>gi|270004334|gb|EFA00782.1| hypothetical protein TcasGA2_TC003668 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R6S2 298 3.6e-25 GTP-binding protein Di-Ras2 OS=Pongo abelii GN=DIRAS2 PE=2 SV=1 PF00025//PF00071//PF01443//PF01926//PF03193//PF08477 ADP-ribosylation factor family//Ras family//Viral (Superfamily 1) RNA helicase//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0006184 small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005525//GO:0005524 GTPase activity//GTP binding//ATP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.47761 BP_3 48.75 0.49 5110 642917076 XP_967651.3 1148 2.5e-122 PREDICTED: GTP-binding protein Di-Ras1 [Tribolium castaneum]>gi|270004334|gb|EFA00782.1| hypothetical protein TcasGA2_TC003668 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R6S2 298 3.8e-25 GTP-binding protein Di-Ras2 OS=Pongo abelii GN=DIRAS2 PE=2 SV=1 PF00071//PF00025//PF08477//PF03193//PF01926//PF01443 Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//Viral (Superfamily 1) RNA helicase GO:0007264//GO:0006184 small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.47763 BP_3 24.15 0.49 2657 642916256 XP_008190949.1 1280 6.5e-138 PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum]>gi|642916258|ref|XP_008190950.1| PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.9e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.47768 BP_3 30.00 1.53 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47770 BP_3 7.16 0.37 1232 642921436 XP_008192865.1 388 8.2e-35 PREDICTED: ral GTPase-activating protein subunit beta isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X10 217 2.3e-16 Ral GTPase-activating protein subunit beta OS=Homo sapiens GN=RALGAPB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47771 BP_3 381.69 2.98 6461 270006298 EFA02746.1 2906 0.0e+00 hypothetical protein TcasGA2_TC008477 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P86410 1324 5.1e-144 Ral GTPase-activating protein subunit beta OS=Rattus norvegicus GN=Ralgapb PE=1 SV=1 PF00237//PF00876//PF02145 Ribosomal protein L22p/L17e//Innexin//Rap/ran-GAP GO:0006412//GO:0042254//GO:0051056 translation//ribosome biogenesis//regulation of small GTPase mediated signal transduction GO:0005096//GO:0003735 GTPase activator activity//structural constituent of ribosome GO:0005921//GO:0005840 gap junction//ribosome KOG1711 Mitochondrial/chloroplast ribosomal protein L22 Cluster-8309.47773 BP_3 47.26 0.62 3962 478257309 ENN77469.1 1230 6.1e-132 hypothetical protein YQE_05997, partial [Dendroctonus ponderosae] -- -- -- -- -- K11324 DMAP1, SWC4, EAF2 DNA methyltransferase 1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11324 Q9NPF5 849 3.8e-89 DNA methyltransferase 1-associated protein 1 OS=Homo sapiens GN=DMAP1 PE=1 SV=1 PF05499 DNA methyltransferase 1-associated protein 1 (DMAP1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2656 DNA methyltransferase 1-associated protein-1 Cluster-8309.47774 BP_3 94.62 0.49 9598 642935083 XP_008197877.1 2530 2.7e-282 PREDICTED: calmodulin-binding transcription activator 2-like isoform X3 [Tribolium castaneum] 642935084 XM_008199656.1 481 0 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- Q9Y6Y1 656 2.2e-66 Calmodulin-binding transcription activator 1 OS=Homo sapiens GN=CAMTA1 PE=1 SV=4 PF00899//PF13606//PF03859//PF00023//PF00612//PF01833 ThiF family//Ankyrin repeat//CG-1 domain//Ankyrin repeat//IQ calmodulin-binding motif//IPT/TIG domain -- -- GO:0003677//GO:0005515//GO:0008641 DNA binding//protein binding//small protein activating enzyme activity GO:0005634 nucleus KOG0520 Uncharacterized conserved protein, contains IPT/TIG domain Cluster-8309.47775 BP_3 774.00 22.46 1953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47777 BP_3 29.29 2.59 837 189238013 XP_001813375.1 468 2.9e-44 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] -- -- -- -- -- K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q704E8 210 9.9e-16 ATP-binding cassette sub-family B member 7, mitochondrial OS=Rattus norvegicus GN=Abcb7 PE=1 SV=1 -- -- -- -- GO:0017111 nucleoside-triphosphatase activity -- -- KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.47778 BP_3 78.28 1.56 2710 189238013 XP_001813375.1 1636 3.5e-179 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 55 3.26516e-17 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1135 1.8e-122 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00664//PF13304//PF00005//PF05393 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Human adenovirus early E3A glycoprotein GO:0055085//GO:0006810//GO:0006200 transmembrane transport//transport//obsolete ATP catabolic process GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.47780 BP_3 142.73 2.53 3014 546682611 ERL92528.1 524 3.4e-50 hypothetical protein D910_09841 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0P3X7 213 1.6e-15 UPF0545 protein C22orf39 homolog OS=Danio rerio PE=3 SV=2 PF03581 Herpesvirus UL33-like protein GO:0019073 viral DNA genome packaging -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.47782 BP_3 210.73 4.91 2360 642921426 XP_008192862.1 1167 7.3e-125 PREDICTED: kelch domain-containing protein 3 [Tribolium castaneum]>gi|270006295|gb|EFA02743.1| hypothetical protein TcasGA2_TC008474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYI2 741 7.5e-77 Kelch domain-containing protein 3 OS=Rattus norvegicus GN=Klhdc3 PE=2 SV=1 PF07646//PF01344//PF03089 Kelch motif//Kelch motif//Recombination activating protein 2 GO:0006310 DNA recombination GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG4693 Uncharacterized conserved protein, contains kelch repeat Cluster-8309.47784 BP_3 9.31 0.32 1682 642919745 XP_008192047.1 1630 1.1e-178 PREDICTED: transmembrane protein 131 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 742 4.1e-77 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3620 Uncharacterized conserved protein Cluster-8309.47785 BP_3 32.00 43.93 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47786 BP_3 48.30 0.82 3148 270009506 EFA05954.1 296 9.7e-24 hypothetical protein TcasGA2_TC008772 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47788 BP_3 8952.12 517.21 1126 91087407 XP_975668.1 598 3.3e-59 PREDICTED: microtubule-associated protein Jupiter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4KBL1 140 1.8e-07 Microtubule-associated protein Jupiter OS=Drosophila mojavensis GN=Jupiter PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47789 BP_3 79.51 1.34 3149 91089227 XP_968078.1 1676 9.3e-184 PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum]>gi|642932923|ref|XP_008197189.1| PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 699 7.4e-72 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF00498 FHA domain -- -- GO:0005515 protein binding -- -- KOG3872 FOG: FHA domain Cluster-8309.4779 BP_3 8.00 0.38 1303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47790 BP_3 27.00 1.66 1075 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47794 BP_3 91.63 2.97 1779 646709836 KDR15525.1 1362 1.3e-147 Vacuolar protein sorting-associated protein 26B-like [Zootermopsis nevadensis] 884922933 XM_003472567.3 171 6.98846e-82 PREDICTED: Cavia porcellus VPS26 retromer complex component B (Vps26b), mRNA K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q9W552 1278 3.0e-139 Vacuolar protein sorting-associated protein 26 OS=Drosophila melanogaster GN=Vps26 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.47795 BP_3 754.05 28.63 1561 91084541 XP_972999.1 1668 3.9e-183 PREDICTED: vacuolar protein sorting-associated protein 26B-like [Tribolium castaneum]>gi|270008666|gb|EFA05114.1| hypothetical protein TcasGA2_TC015215 [Tribolium castaneum] 545849340 XM_003482653.2 172 1.70017e-82 PREDICTED: Sus scrofa vacuolar protein sorting-associated protein 26B-like (LOC100738900), mRNA K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q9W552 1261 2.5e-137 Vacuolar protein sorting-associated protein 26 OS=Drosophila melanogaster GN=Vps26 PE=2 SV=1 -- -- GO:0007034 vacuolar transport -- -- GO:0030904 retromer complex KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.47796 BP_3 101.49 0.63 8050 642918330 XP_008199110.1 2885 0.0e+00 PREDICTED: tyrosine-protein kinase Abl [Tribolium castaneum] 815766251 XM_012363285.1 453 0 PREDICTED: Linepithema humile tyrosine-protein kinase Abl (LOC105670007), mRNA K06619 ABL1 abelson tyrosine-protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06619 P00522 2331 1.1e-260 Tyrosine-protein kinase Abl OS=Drosophila melanogaster GN=Abl PE=1 SV=3 PF00069//PF08919//PF00018//PF14604//PF07714 Protein kinase domain//F-actin binding//SH3 domain//Variant SH3 domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0004715//GO:0005524 protein binding//protein kinase activity//non-membrane spanning protein tyrosine kinase activity//ATP binding -- -- KOG4278 Protein tyrosine kinase Cluster-8309.47797 BP_3 293.24 1.92 7639 642918330 XP_008199110.1 2916 0.0e+00 PREDICTED: tyrosine-protein kinase Abl [Tribolium castaneum] 815766251 XM_012363285.1 447 0 PREDICTED: Linepithema humile tyrosine-protein kinase Abl (LOC105670007), mRNA K06619 ABL1 abelson tyrosine-protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06619 P00522 2325 5.1e-260 Tyrosine-protein kinase Abl OS=Drosophila melanogaster GN=Abl PE=1 SV=3 PF14604//PF00018//PF00069//PF08919//PF07714 Variant SH3 domain//SH3 domain//Protein kinase domain//F-actin binding//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0004715 protein binding//protein kinase activity//ATP binding//non-membrane spanning protein tyrosine kinase activity -- -- KOG4278 Protein tyrosine kinase Cluster-8309.47798 BP_3 1637.74 11.32 7266 642918330 XP_008199110.1 5143 0.0e+00 PREDICTED: tyrosine-protein kinase Abl [Tribolium castaneum] 815766251 XM_012363285.1 447 0 PREDICTED: Linepithema humile tyrosine-protein kinase Abl (LOC105670007), mRNA K06619 ABL1 abelson tyrosine-protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06619 P00522 2688 4.0e-302 Tyrosine-protein kinase Abl OS=Drosophila melanogaster GN=Abl PE=1 SV=3 PF14604//PF00018//PF08919//PF00069//PF07714 Variant SH3 domain//SH3 domain//F-actin binding//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0004715//GO:0005524 protein binding//protein kinase activity//non-membrane spanning protein tyrosine kinase activity//ATP binding -- -- KOG4278 Protein tyrosine kinase Cluster-8309.47799 BP_3 31.35 0.46 3546 91087251 XP_975522.1 315 6.9e-26 PREDICTED: uncharacterized protein LOC664422 [Tribolium castaneum]>gi|270009553|gb|EFA06001.1| hypothetical protein TcasGA2_TC008827 [Tribolium castaneum] -- -- -- -- -- K04402 GADD45 growth arrest and DNA-damage-inducible protein http://www.genome.jp/dbget-bin/www_bget?ko:K04402 -- -- -- -- PF06992 Replication protein P GO:0006270//GO:0051726//GO:0006950 DNA replication initiation//regulation of cell cycle//response to stress -- -- GO:0005634 nucleus -- -- Cluster-8309.478 BP_3 3.00 0.61 527 554548683 XP_005868880.1 766 5.1e-79 PREDICTED: LOW QUALITY PROTEIN: ribosomal protein S16 [Myotis brandtii] 71482588 NM_001020.4 527 0 Homo sapiens ribosomal protein S16 (RPS16), mRNA K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 Q3T0X6 744 7.5e-78 40S ribosomal protein S16 OS=Bos taurus GN=RPS16 PE=2 SV=3 PF00380 Ribosomal protein S9/S16 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-8309.47800 BP_3 12.03 0.35 1946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47801 BP_3 273.07 3.11 4525 642933801 XP_008197340.1 1564 1.3e-170 PREDICTED: sphingosine-1-phosphate phosphatase 1-like [Tribolium castaneum]>gi|270013628|gb|EFA10076.1| hypothetical protein TcasGA2_TC012252 [Tribolium castaneum] 242013612 XM_002427452.1 98 6.84423e-41 Pediculus humanus corporis sphingosine-1-phosphate phosphatase, putative, mRNA K04716 SGPP1 sphingosine-1-phosphate phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04716 Q9BX95 650 5.1e-66 Sphingosine-1-phosphate phosphatase 1 OS=Homo sapiens GN=SGPP1 PE=1 SV=2 -- -- GO:0008152 metabolic process GO:0003824 catalytic activity GO:0016020 membrane KOG2822 Sphingoid base-phosphate phosphatase Cluster-8309.47802 BP_3 906.38 41.24 1351 642923823 XP_008193894.1 754 3.3e-77 PREDICTED: uncharacterized protein LOC103313156 [Tribolium castaneum]>gi|270007762|gb|EFA04210.1| hypothetical protein TcasGA2_TC014459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF13903//PF09446 Clc-like//PMP-22/EMP/MP20/Claudin tight junction//VMA21-like domain GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47803 BP_3 1171.07 6.98 8374 642938555 XP_008199840.1 3495 0.0e+00 PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum]>gi|642938557|ref|XP_008199841.1| PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum] 642938558 XR_511746.1 676 0 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X3, misc_RNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 6.9e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF02985//PF00514//PF01602//PF01312//PF09258 HEAT repeat//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//FlhB HrpN YscU SpaS Family//Glycosyl transferase family 64 domain GO:0015012//GO:0009306//GO:0006024//GO:0016192//GO:0006886 heparan sulfate proteoglycan biosynthetic process//protein secretion//glycosaminoglycan biosynthetic process//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0016020//GO:0030117//GO:0016021 membrane//membrane coat//integral component of membrane KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins Cluster-8309.47805 BP_3 591.00 23.48 1505 332375150 AEE62716.1 1178 2.5e-126 unknown [Dendroctonus ponderosae] 195568600 XM_002102266.1 65 4.9571e-23 Drosophila simulans GD19834 (Dsim\GD19834), mRNA K04405 ECSIT evolutionarily conserved signaling intermediate in Toll pathway http://www.genome.jp/dbget-bin/www_bget?ko:K04405 Q9U6M0 968 2.3e-103 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Drosophila melanogaster GN=ECSIT PE=1 SV=2 PF01777 Ribosomal L27e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3941 Intermediate in Toll signal transduction pathway (ECSIT) Cluster-8309.47806 BP_3 731.88 5.20 7080 91077136 XP_971386.1 4613 0.0e+00 PREDICTED: methyl-CpG-binding domain protein 5 isoform X2 [Tribolium castaneum]>gi|270001717|gb|EEZ98164.1| hypothetical protein TcasGA2_TC000591 [Tribolium castaneum] 462383301 APGK01021303.1 73 8.47656e-27 Dendroctonus ponderosae Seq01021313, whole genome shotgun sequence -- -- -- -- Q9P267 256 3.9e-20 Methyl-CpG-binding domain protein 5 OS=Homo sapiens GN=MBD5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47807 BP_3 63.57 0.52 6160 91077136 XP_971386.1 4131 0.0e+00 PREDICTED: methyl-CpG-binding domain protein 5 isoform X2 [Tribolium castaneum]>gi|270001717|gb|EEZ98164.1| hypothetical protein TcasGA2_TC000591 [Tribolium castaneum] 462383301 APGK01021303.1 73 7.37282e-27 Dendroctonus ponderosae Seq01021313, whole genome shotgun sequence -- -- -- -- Q9P267 256 3.4e-20 Methyl-CpG-binding domain protein 5 OS=Homo sapiens GN=MBD5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47809 BP_3 697.67 4.94 7092 91077136 XP_971386.1 4613 0.0e+00 PREDICTED: methyl-CpG-binding domain protein 5 isoform X2 [Tribolium castaneum]>gi|270001717|gb|EEZ98164.1| hypothetical protein TcasGA2_TC000591 [Tribolium castaneum] 462383301 APGK01021303.1 73 8.491e-27 Dendroctonus ponderosae Seq01021313, whole genome shotgun sequence -- -- -- -- Q9P267 256 3.9e-20 Methyl-CpG-binding domain protein 5 OS=Homo sapiens GN=MBD5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47811 BP_3 386.00 9.23 2307 91086585 XP_973508.1 2209 1.1e-245 PREDICTED: trafficking protein particle complex subunit 12 [Tribolium castaneum]>gi|270010359|gb|EFA06807.1| hypothetical protein TcasGA2_TC009746 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K2L8 890 3.9e-94 Trafficking protein particle complex subunit 12 OS=Mus musculus GN=Trappc12 PE=1 SV=2 PF13374//PF13181//PF07721//PF00515//PF13414//PF13174//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG2796 Uncharacterized conserved protein Cluster-8309.47813 BP_3 39.84 0.44 4611 642927197 XP_008195176.1 1633 1.3e-178 PREDICTED: uncharacterized protein LOC662380 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47815 BP_3 351.99 28.17 894 332375216 AEE62749.1 600 1.5e-59 unknown [Dendroctonus ponderosae]>gi|478260771|gb|ENN80443.1| hypothetical protein YQE_03135, partial [Dendroctonus ponderosae]>gi|546679580|gb|ERL90028.1| hypothetical protein D910_07386 [Dendroctonus ponderosae] -- -- -- -- -- K17197 NKIRAS NF-kappa-B inhibitor-interacting Ras-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17197 Q9V4L4 336 2.6e-30 NF-kappa-B inhibitor-interacting Ras-like protein OS=Drosophila melanogaster GN=kappaB-Ras PE=1 SV=1 PF00004//PF00025//PF08477//PF01926//PF00493//PF00071//PF00931//PF01637 ATPase family associated with various cellular activities (AAA)//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//MCM2/3/5 family//Ras family//NB-ARC domain//Archaeal ATPase GO:0006260//GO:0007264 DNA replication//small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003677//GO:0043531 ATP binding//GTP binding//DNA binding//ADP binding -- -- -- -- Cluster-8309.47816 BP_3 103.84 2.26 2503 642929027 XP_973541.3 829 1.2e-85 PREDICTED: probable maleylacetoacetate isomerase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01800 maiA, GSTZ1 maleylacetoacetate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01800 Q9VHD2 786 4.8e-82 Probable maleylacetoacetate isomerase 2 OS=Drosophila melanogaster GN=GstZ2 PE=1 SV=1 PF13409//PF02798//PF00462//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0009055//GO:0015035//GO:0005515 electron carrier activity//protein disulfide oxidoreductase activity//protein binding -- -- KOG0868 Glutathione S-transferase Cluster-8309.47823 BP_3 58.00 1.32 2403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.47824 BP_3 21.94 1.02 1328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47826 BP_3 102.00 2.69 2116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01985 CRS1 / YhbY (CRM) domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.47827 BP_3 13.86 1.05 926 665792068 XP_008543619.1 202 2.3e-13 PREDICTED: zinc finger protein 888-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P17010 167 1.1e-10 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF16622//PF04988//PF01096//PF13465//PF00096 zinc-finger C2H2-type//A-kinase anchoring protein 95 (AKAP95)//Transcription factor S-II (TFIIS)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006351 transcription, DNA-templated GO:0003677//GO:0003676//GO:0008270//GO:0046872 DNA binding//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.47828 BP_3 24.00 26.41 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47830 BP_3 180.80 2.86 3343 91082299 XP_974015.1 1414 2.4e-153 PREDICTED: cell differentiation protein RCD1 homolog [Tribolium castaneum]>gi|270007201|gb|EFA03649.1| hypothetical protein TcasGA2_TC013743 [Tribolium castaneum] -- -- -- -- -- K12606 RCD1, CNOT9, CAF40 CCR4-NOT transcription complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12606 Q5PQL2 1248 1.7e-135 Cell differentiation protein RCD1 homolog OS=Rattus norvegicus GN=Rqcd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3036 Protein involved in cell differentiation/sexual development Cluster-8309.47831 BP_3 8.04 0.45 1148 642923056 XP_008200513.1 322 3.4e-27 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X4 [Tribolium castaneum]>gi|270006595|gb|EFA03043.1| hypothetical protein TcasGA2_TC010469 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47832 BP_3 336.01 1.50 11123 642911559 XP_970343.3 5214 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4055 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF03808//PF08074//PF00640//PF04689//PF00176//PF04851 Glycosyl transferase WecB/TagA/CpsF family//CHDCT2 (NUC038) domain//Phosphotyrosine interaction domain (PTB/PID)//DNA binding protein S1FA//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0008270//GO:0016818//GO:0016787//GO:0003677//GO:0005524//GO:0005515 zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//hydrolase activity//DNA binding//ATP binding//protein binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.47835 BP_3 40.58 0.63 3418 91084169 XP_971096.1 1602 3.8e-175 PREDICTED: alpha-1,2-mannosyltransferase ALG9 [Tribolium castaneum]>gi|270006637|gb|EFA03085.1| hypothetical protein TcasGA2_TC012991 [Tribolium castaneum] -- -- -- -- -- K03846 ALG9 alpha-1,2-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03846 Q8VDI9 966 8.8e-103 Alpha-1,2-mannosyltransferase ALG9 OS=Mus musculus GN=Alg9 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2515 Mannosyltransferase Cluster-8309.47837 BP_3 162.14 17.28 744 478254757 ENN74994.1 180 6.5e-11 hypothetical protein YQE_08451, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7PSY2 164 1.9e-10 UPF0729 protein AGAP000931 OS=Anopheles gambiae GN=AGAP000931 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4784 BP_3 14.00 0.73 1210 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47840 BP_3 767.31 16.66 2511 859132814 AKO63320.1 1120 2.2e-119 mevalonate kinase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9R008 406 5.6e-38 Mevalonate kinase OS=Mus musculus GN=Mvk PE=2 SV=1 PF00288//PF04055 GHMP kinases N terminal domain//Radical SAM superfamily -- -- GO:0051536//GO:0005524//GO:0003824 iron-sulfur cluster binding//ATP binding//catalytic activity -- -- KOG1511 Mevalonate kinase MVK/ERG12 Cluster-8309.47842 BP_3 7.91 2.36 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47843 BP_3 235.70 12.52 1199 91094895 XP_973250.1 912 1.4e-95 PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923028|ref|XP_008200501.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923030|ref|XP_008200502.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- H3BPM6 338 2.1e-30 MKRN2 opposite strand protein OS=Homo sapiens GN=MKRN2OS PE=4 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.47844 BP_3 58.63 0.76 4002 91091542 XP_970835.1 1645 4.6e-180 PREDICTED: retinal dehydrogenase 1 [Tribolium castaneum]>gi|270000922|gb|EEZ97369.1| hypothetical protein TcasGA2_TC011192 [Tribolium castaneum] -- -- -- -- -- K07249 E1.2.1.36 retinal dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07249 Q62148 1318 1.6e-143 Retinal dehydrogenase 2 OS=Mus musculus GN=Aldh1a2 PE=2 SV=2 PF00705//PF00171 Proliferating cell nuclear antigen, N-terminal domain//Aldehyde dehydrogenase family GO:0008152//GO:0006275//GO:0055114 metabolic process//regulation of DNA replication//oxidation-reduction process GO:0003677//GO:0016491//GO:0016620 DNA binding//oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.47845 BP_3 319.47 4.43 3771 91091542 XP_970835.1 1726 1.8e-189 PREDICTED: retinal dehydrogenase 1 [Tribolium castaneum]>gi|270000922|gb|EEZ97369.1| hypothetical protein TcasGA2_TC011192 [Tribolium castaneum] -- -- -- -- -- K07249 E1.2.1.36 retinal dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07249 Q66HF8 1365 5.3e-149 Aldehyde dehydrogenase X, mitochondrial OS=Rattus norvegicus GN=Aldh1b1 PE=1 SV=1 PF00171//PF00705 Aldehyde dehydrogenase family//Proliferating cell nuclear antigen, N-terminal domain GO:0008152//GO:0006275//GO:0055114 metabolic process//regulation of DNA replication//oxidation-reduction process GO:0003677//GO:0016491 DNA binding//oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.47846 BP_3 210.87 3.48 3216 91084489 XP_971806.1 629 2.4e-62 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103 CD20-like family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47848 BP_3 42.63 1.12 2132 642915964 XP_008190829.1 1006 3.1e-106 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 316 1.3e-27 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47850 BP_3 11.91 0.52 1389 662191266 XP_008468441.1 682 7.5e-69 PREDICTED: transposable element P transposase [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7M3K2 364 2.3e-33 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.47851 BP_3 164.00 2.69 3229 642939454 XP_008200409.1 1602 3.6e-175 PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|270016515|gb|EFA12961.1| hypothetical protein TcasGA2_TC001412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 696 1.7e-71 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.47854 BP_3 1324.00 12.61 5351 478257233 ENN77396.1 1644 8.1e-180 hypothetical protein YQE_06221, partial [Dendroctonus ponderosae] 751455975 XM_011184231.1 54 2.33423e-16 PREDICTED: Bactrocera cucurbitae heparan-sulfate 6-O-sulfotransferase 2 (LOC105212331), transcript variant X2, mRNA K02514 HS6ST1 heparan sulfate 6-O-sulfotransferase HS6ST1 http://www.genome.jp/dbget-bin/www_bget?ko:K02514 Q76KB2 785 1.3e-81 Heparan-sulfate 6-O-sulfotransferase 1 OS=Gallus gallus GN=HS6ST1 PE=1 SV=4 PF00622//PF06990//PF03567 SPRY domain//Galactose-3-O-sulfotransferase//Sulfotransferase family GO:0009058//GO:0006687 biosynthetic process//glycosphingolipid metabolic process GO:0008146//GO:0005515//GO:0001733 sulfotransferase activity//protein binding//galactosylceramide sulfotransferase activity GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG4030 Uncharacterized conserved protein, contains SPRY domain Cluster-8309.47856 BP_3 25.00 1.37 1171 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47857 BP_3 5.00 7.43 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47859 BP_3 118.20 3.16 2092 478254028 ENN74320.1 1274 2.5e-137 hypothetical protein YQE_09291, partial [Dendroctonus ponderosae] -- -- -- -- -- K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 Q9D2A5 304 3.1e-26 Cyclic AMP-responsive element-binding protein 3-like protein 4 OS=Mus musculus GN=Creb3l4 PE=1 SV=1 PF03131//PF04281//PF11365//PF07716//PF00170 bZIP Maf transcription factor//Mitochondrial import receptor subunit Tom22//Protein of unknown function (DUF3166)//Basic region leucine zipper//bZIP transcription factor GO:0006355//GO:0010506//GO:0006886 regulation of transcription, DNA-templated//regulation of autophagy//intracellular protein transport GO:0043565//GO:0003700//GO:0003677 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005741//GO:0005615//GO:0005634//GO:0005667 mitochondrial outer membrane//extracellular space//nucleus//transcription factor complex KOG0709 CREB/ATF family transcription factor Cluster-8309.47861 BP_3 47.87 0.36 6780 642917203 XP_008191162.1 5579 0.0e+00 PREDICTED: protein virilizer [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AIV2 848 8.5e-89 Protein virilizer homolog OS=Mus musculus GN=Kiaa1429 PE=1 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.47865 BP_3 86.72 1.23 3702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00220 Neurohypophysial hormones, N-terminal Domain GO:0007218 neuropeptide signaling pathway GO:0005185 neurohypophyseal hormone activity GO:0005576 extracellular region -- -- Cluster-8309.47868 BP_3 55.00 4.90 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47869 BP_3 1270.00 15.91 4139 642913457 XP_008201020.1 4038 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.2e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00023//PF00784//PF13606 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.47872 BP_3 680.00 18.92 2024 642910650 XP_968863.2 2068 2.1e-229 PREDICTED: protein hook [Tribolium castaneum] -- -- -- -- -- K16536 HOOK3 protein HOOK3 http://www.genome.jp/dbget-bin/www_bget?ko:K16536 Q17AF4 1026 5.8e-110 Protein hook OS=Aedes aegypti GN=hk PE=3 SV=1 PF01763//PF01873 Herpesvirus UL6 like//Domain found in IF2B/IF5 GO:0006413//GO:0006323//GO:0006446 translational initiation//DNA packaging//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.47874 BP_3 19.93 2.24 720 642925421 XP_008194544.1 245 1.8e-18 PREDICTED: caldesmon-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47876 BP_3 4.00 9.35 290 749793177 XP_011149868.1 178 4.3e-11 PREDICTED: MLX-interacting protein isoform X2 [Harpegnathos saltator] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 -- -- -- -- PF04977//PF07716//PF00170//PF00010 Septum formation initiator//Basic region leucine zipper//bZIP transcription factor//Helix-loop-helix DNA-binding domain GO:0007049//GO:0006355 cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0046983//GO:0043565 transcription factor activity, sequence-specific DNA binding//protein dimerization activity//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.47877 BP_3 70.97 0.54 6589 478253916 ENN74208.1 1517 5.3e-165 hypothetical protein YQE_09181, partial [Dendroctonus ponderosae] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9QZR8 268 1.5e-21 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF13180//PF00303//PF04977//PF05531//PF00595//PF00170//PF00010//PF06005//PF10186 PDZ domain//Thymidylate synthase//Septum formation initiator//Nucleopolyhedrovirus P10 protein//PDZ domain (Also known as DHR or GLGF)//bZIP transcription factor//Helix-loop-helix DNA-binding domain//Protein of unknown function (DUF904)//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006231//GO:0006355//GO:0006206//GO:0007049//GO:0010508//GO:0000917//GO:0043093 dTMP biosynthetic process//regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process//cell cycle//positive regulation of autophagy//barrier septum assembly//FtsZ-dependent cytokinesis GO:0046983//GO:0005515//GO:0043565//GO:0004799//GO:0003700 protein dimerization activity//protein binding//sequence-specific DNA binding//thymidylate synthase activity//transcription factor activity, sequence-specific DNA binding GO:0019028//GO:0005667//GO:0005737 viral capsid//transcription factor complex//cytoplasm -- -- Cluster-8309.47878 BP_3 20.36 0.48 2350 91081429 XP_973458.1 1554 9.7e-170 PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|642920877|ref|XP_008192597.1| PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|270006127|gb|EFA02575.1| hypothetical protein TcasGA2_TC008293 [Tribolium castaneum] 749790449 XM_011150162.1 130 5.74328e-59 PREDICTED: Harpegnathos saltator ATP-binding cassette sub-family G member 4 (LOC105188614), mRNA K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 Q9H172 946 1.3e-100 ATP-binding cassette sub-family G member 4 OS=Homo sapiens GN=ABCG4 PE=1 SV=2 PF01926//PF13304//PF03193//PF00005 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function, DUF258//ABC transporter GO:0006200 obsolete ATP catabolic process GO:0003924//GO:0016887//GO:0005525//GO:0005524 GTPase activity//ATPase activity//GTP binding//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.47879 BP_3 458.52 9.85 2535 642924099 XP_008194004.1 1356 9.5e-147 PREDICTED: division abnormally delayed protein [Tribolium castaneum] -- -- -- -- -- K02306 DALLY dally http://www.genome.jp/dbget-bin/www_bget?ko:K02306 Q24114 699 6.0e-72 Division abnormally delayed protein OS=Drosophila melanogaster GN=dally PE=1 SV=1 PF01392//PF01153//PF03176//PF07657 Fz domain//Glypican//MMPL family//N terminus of Notch ligand GO:0007219//GO:0007275 Notch signaling pathway//multicellular organismal development GO:0005515//GO:0043395 protein binding//heparan sulfate proteoglycan binding GO:0016021//GO:0016020//GO:0005578 integral component of membrane//membrane//proteinaceous extracellular matrix -- -- Cluster-8309.47880 BP_3 8.00 0.98 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47881 BP_3 5.90 0.43 960 478257780 ENN77923.1 505 1.7e-48 hypothetical protein YQE_05600, partial [Dendroctonus ponderosae]>gi|546686002|gb|ERL95408.1| hypothetical protein D910_12672 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZJE4 269 1.6e-22 UPF0454 protein C12orf49 homolog OS=Gallus gallus GN=RCJMB04_18o22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3136 Uncharacterized conserved protein Cluster-8309.47882 BP_3 467.10 36.18 914 91087999 XP_973740.1 783 9.5e-81 PREDICTED: UPF0454 protein C12orf49 homolog [Tribolium castaneum]>gi|270011897|gb|EFA08345.1| hypothetical protein TcasGA2_TC005988 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNT2 462 6.5e-45 UPF0454 protein C12orf49 homolog OS=Xenopus laevis PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3136 Uncharacterized conserved protein Cluster-8309.47883 BP_3 1566.20 19.19 4226 642916660 XP_008192067.1 4186 0.0e+00 PREDICTED: serine/threonine-protein kinase N isoform X3 [Tribolium castaneum] 242022369 XM_002431568.1 129 3.73752e-58 Pediculus humanus corporis conserved hypothetical protein, mRNA K06071 PKN protein kinase N http://www.genome.jp/dbget-bin/www_bget?ko:K06071 Q16513 2483 1.4e-278 Serine/threonine-protein kinase N2 OS=Homo sapiens GN=PKN2 PE=1 SV=1 PF00069//PF02185//PF00433//PF07714 Protein kinase domain//Hr1 repeat//Protein kinase C terminal domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468//GO:0007165 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//signal transduction GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.47884 BP_3 518.12 5.70 4675 642927778 XP_008195402.1 2148 2.6e-238 PREDICTED: uncharacterized protein LOC658369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103//PF07690//PF07710 CD20-like family//Major Facilitator Superfamily//P53 tetramerisation motif GO:0051262//GO:0055085 protein tetramerization//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47885 BP_3 14.90 0.31 2594 642929180 XP_008195726.1 519 1.1e-49 PREDICTED: DNA-directed RNA polymerase III subunit RPC7-like [Tribolium castaneum] -- -- -- -- -- K15455 KTI11, DPH3 diphthamide biosynthesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15455 Q9VGQ9 190 6.4e-13 DPH3 homolog OS=Drosophila melanogaster GN=CG14701 PE=3 SV=1 PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- KOG2923 Uncharacterized conserved protein Cluster-8309.47886 BP_3 950.64 6.84 6989 642934824 XP_008197825.1 4092 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 5.1e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.47887 BP_3 400.97 5.72 3669 642934824 XP_008197825.1 4487 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 2.7e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.47888 BP_3 129.47 0.76 8482 642934828 XP_008197827.1 4092 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 6.2e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.47889 BP_3 243.95 3.56 3597 642934830 XP_008197828.1 4401 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 2.6e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.47894 BP_3 291.06 2.93 5073 642934565 XP_008197717.1 1516 5.3e-165 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47895 BP_3 1.00 1.27 318 546686701 ERL95808.1 171 3.0e-10 hypothetical protein D910_00344, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47898 BP_3 10.04 0.37 1613 270017159 EFA13605.1 557 2.7e-54 hypothetical protein TcasGA2_TC016030 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47899 BP_3 1702.86 26.30 3413 642933817 XP_008197388.1 565 6.8e-55 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.479 BP_3 11.84 4.59 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.47900 BP_3 587.19 39.57 1007 642926177 XP_008194817.1 792 9.5e-82 PREDICTED: protein LSM12 homolog A-like [Tribolium castaneum]>gi|270008537|gb|EFA04985.1| hypothetical protein TcasGA2_TC015064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZML5 382 1.4e-35 Protein LSM12 homolog OS=Gallus gallus GN=LSM12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4401 Uncharacterized conserved protein Cluster-8309.47901 BP_3 63.17 1.87 1923 642917480 XP_008191219.1 777 1.0e-79 PREDICTED: probable RNA-binding protein 18 [Tribolium castaneum]>gi|270004407|gb|EFA00855.1| hypothetical protein TcasGA2_TC003758 [Tribolium castaneum] 642917479 XM_008192997.1 137 6.01634e-63 PREDICTED: Tribolium castaneum probable RNA-binding protein 18 (LOC103312423), mRNA -- -- -- -- Q6PBM8 292 7.1e-25 Probable RNA-binding protein 18 OS=Danio rerio GN=rbm18 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.47902 BP_3 636.71 76.29 694 642927976 XP_008195469.1 559 6.8e-55 PREDICTED: leptin receptor gene-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3Y064 399 1.0e-37 Leptin receptor gene-related protein OS=Takifugu rubripes GN=leprot PE=2 SV=1 PF07440//PF07155 Caerin 1 protein//ECF-type riboflavin transporter, S component -- -- -- -- GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.47903 BP_3 8.75 0.38 1397 642927976 XP_008195469.1 561 8.1e-55 PREDICTED: leptin receptor gene-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3Y064 371 3.6e-34 Leptin receptor gene-related protein OS=Takifugu rubripes GN=leprot PE=2 SV=1 PF07155//PF07440 ECF-type riboflavin transporter, S component//Caerin 1 protein -- -- -- -- GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.47904 BP_3 45.53 0.65 3686 270012487 EFA08935.1 2481 4.9e-277 hypothetical protein TcasGA2_TC006642 [Tribolium castaneum] 645037466 XM_008219044.1 211 8.49403e-104 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1544 9.0e-170 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF09604//PF02214//PF00520 F subunit of K+-transporting ATPase (Potass_KdpF)//BTB/POZ domain//Ion transport protein GO:0043462//GO:0055085//GO:0006813//GO:0051260//GO:0006811 regulation of ATPase activity//transmembrane transport//potassium ion transport//protein homooligomerization//ion transport GO:0008556//GO:0005216 potassium-transporting ATPase activity//ion channel activity GO:0005886//GO:0016020 plasma membrane//membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.47907 BP_3 21.75 0.31 3683 478257325 ENN77485.1 1213 5.3e-130 hypothetical protein YQE_06013, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47908 BP_3 326.00 3.80 4425 642934496 XP_008197689.1 1102 4.7e-117 PREDICTED: nascent polypeptide-associated complex subunit alpha, muscle-specific form-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PR54 167 5.1e-10 Telomere-associated protein RIF1 OS=Mus musculus GN=Rif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47909 BP_3 564.84 2.14 13028 270007354 EFA03802.1 5836 0.0e+00 hypothetical protein TcasGA2_TC013915 [Tribolium castaneum] 642917043 XM_008192874.1 352 0 PREDICTED: Tribolium castaneum diacylglycerol kinase eta-like (LOC103312380), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 B4K6T8 2049 8.8e-228 Diacylglycerol kinase eta OS=Drosophila mojavensis GN=GI24133 PE=3 SV=1 PF00536//PF00609//PF00130//PF02017//PF07647//PF00749//PF07649//PF02198//PF16866//PF00781 SAM domain (Sterile alpha motif)//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//CIDE-N domain//SAM domain (Sterile alpha motif)//tRNA synthetases class I (E and Q), catalytic domain//C1-like domain//Sterile alpha motif (SAM)/Pointed domain//PHD-finger//Diacylglycerol kinase catalytic domain GO:0043039//GO:0007205//GO:0009395//GO:0046486//GO:0006915//GO:0035556//GO:0055114 tRNA aminoacylation//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process//apoptotic process//intracellular signal transduction//oxidation-reduction process GO:0005515//GO:0004143//GO:0047134//GO:0016876//GO:0016301//GO:0043565//GO:0005524 protein binding//diacylglycerol kinase activity//protein-disulfide reductase activity//ligase activity, forming aminoacyl-tRNA and related compounds//kinase activity//sequence-specific DNA binding//ATP binding GO:0005634//GO:0005622 nucleus//intracellular KOG1170 Diacylglycerol kinase Cluster-8309.47910 BP_3 898.00 20.62 2391 642936706 XP_008198547.1 835 2.3e-86 PREDICTED: uncharacterized protein C17orf85 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q803E1 227 3.0e-17 Uncharacterized protein C17orf85 homolog OS=Danio rerio GN=zgc:55870 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47914 BP_3 92.87 1.28 3784 546676181 ERL87248.1 2332 9.6e-260 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9I9 664 1.0e-67 Mycosubtilin synthase subunit C OS=Bacillus subtilis GN=mycC PE=3 SV=1 PF02733//PF00501 Dak1 domain//AMP-binding enzyme GO:0006071//GO:0046486//GO:0008152 glycerol metabolic process//glycerolipid metabolic process//metabolic process GO:0004371//GO:0003824 glycerone kinase activity//catalytic activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.47915 BP_3 34.00 8.05 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47919 BP_3 199.10 2.81 3710 478252950 ENN73334.1 1210 1.2e-129 hypothetical protein YQE_10095, partial [Dendroctonus ponderosae]>gi|546679632|gb|ERL90063.1| hypothetical protein D910_07419 [Dendroctonus ponderosae] -- -- -- -- -- K00637 E2.3.1.26, SOAT sterol O-acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00637 Q60457 838 6.7e-88 Sterol O-acyltransferase 1 OS=Cricetulus griseus GN=SOAT1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0380 Sterol O-acyltransferase/Diacylglycerol O-acyltransferase Cluster-8309.47920 BP_3 237.54 4.15 3051 91093909 XP_970018.1 939 2.6e-98 PREDICTED: cation transport regulator-like protein 1 [Tribolium castaneum]>gi|270014507|gb|EFA10955.1| hypothetical protein TcasGA2_TC004115 [Tribolium castaneum] -- -- -- -- -- K07232 chaC cation transport protein ChaC http://www.genome.jp/dbget-bin/www_bget?ko:K07232 Q9BUX1 467 5.7e-45 Glutathione-specific gamma-glutamylcyclotransferase 1 OS=Homo sapiens GN=CHAC1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47922 BP_3 25.92 0.75 1960 270008949 EFA05397.1 1196 2.6e-128 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 626 1.3e-63 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47924 BP_3 130.21 2.97 2408 189240752 XP_968856.2 777 1.2e-79 PREDICTED: uncharacterized protein LOC657295 isoform X2 [Tribolium castaneum]>gi|642934166|ref|XP_008199634.1| PREDICTED: uncharacterized protein LOC657295 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14135 151 2.0e-08 Transcription cofactor vestigial-like protein 4 OS=Homo sapiens GN=VGLL4 PE=1 SV=4 PF15245//PF07545 Transcription cofactor vestigial-like protein 4//Vestigial/Tondu family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.47926 BP_3 172.40 6.10 1655 91076236 XP_973093.1 520 5.4e-50 PREDICTED: protein KRTCAP2 homolog [Tribolium castaneum]>gi|270014546|gb|EFA10994.1| hypothetical protein TcasGA2_TC004578 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1HQF8 376 1.1e-34 Protein KRTCAP2 homolog OS=Aedes aegypti GN=AAEL007634 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4615 Uncharacterized conserved protein Cluster-8309.47927 BP_3 14.52 0.36 2218 270014745 EFA11193.1 1036 1.1e-109 hypothetical protein TcasGA2_TC004801 [Tribolium castaneum] 158297902 XM_318050.4 90 9.32267e-37 Anopheles gambiae str. PEST AGAP004766-PA (AgaP_AGAP004766) mRNA, complete cds K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I190 957 6.3e-102 Endophilin-A OS=Drosophila virilis GN=endoA PE=3 SV=1 PF03114 BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation Cluster-8309.47933 BP_3 121.61 1.25 4965 642911714 XP_008200711.1 876 8.5e-91 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 704 3.1e-72 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.47934 BP_3 98.41 2.82 1974 478257290 ENN77453.1 1543 1.5e-168 hypothetical protein YQE_06277, partial [Dendroctonus ponderosae] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 942 3.1e-100 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.47936 BP_3 2.00 0.60 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47939 BP_3 283.24 1.75 8098 546686183 ERL95563.1 1046 2.7e-110 hypothetical protein D910_12824, partial [Dendroctonus ponderosae] -- -- -- -- -- K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q9QXF8 603 2.6e-60 Glycine N-methyltransferase OS=Mus musculus GN=Gnmt PE=1 SV=3 PF06220//PF00076//PF09249//PF01885//PF08241//PF01909 U1 zinc finger//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA nucleotidyltransferase, second domain//RNA 2'-phosphotransferase, Tpt1 / KptA family//Methyltransferase domain//Nucleotidyltransferase domain GO:0008033//GO:0008152//GO:0006388 tRNA processing//metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0008168//GO:0008270//GO:0016772//GO:0003676//GO:0016779//GO:0004810//GO:0016437 methyltransferase activity//zinc ion binding//transferase activity, transferring phosphorus-containing groups//nucleic acid binding//nucleotidyltransferase activity//tRNA adenylyltransferase activity//tRNA cytidylyltransferase activity -- -- KOG2278 RNA:NAD 2'-phosphotransferase TPT1 Cluster-8309.47940 BP_3 395.12 2.79 7117 91081013 XP_975219.1 1786 3.7e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 4.3e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF00096//PF01956//PF13465//PF13912 Zinc finger, C2H2 type//Integral membrane protein DUF106//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding GO:0016020 membrane -- -- Cluster-8309.47941 BP_3 64.12 1.05 3247 91081013 XP_975219.1 1786 1.7e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 2.0e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47944 BP_3 806.40 21.86 2070 642911723 XP_008200714.1 359 3.2e-31 PREDICTED: scaffold attachment factor B2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80YR5 202 2.1e-14 Scaffold attachment factor B2 OS=Mus musculus GN=Safb2 PE=2 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.47947 BP_3 9.00 2.99 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47948 BP_3 4.00 0.33 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47949 BP_3 474.48 3.03 7828 642925217 XP_008194472.1 2663 8.2e-298 PREDICTED: zinc finger protein 729-like isoform X1 [Tribolium castaneum]>gi|270008760|gb|EFA05208.1| hypothetical protein TcasGA2_TC015347 [Tribolium castaneum] 194761711 XM_001963036.1 87 1.54703e-34 Drosophila ananassae GF15759 (Dana\GF15759), mRNA -- -- -- -- Q9VL13 907 1.4e-95 MOB kinase activator-like 3 OS=Drosophila melanogaster GN=Mob3 PE=2 SV=1 PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG1903 Cell cycle-associated protein Cluster-8309.47951 BP_3 344.09 2.02 8521 642924897 XP_008194088.1 5244 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P19137 1408 1.2e-153 Laminin subunit alpha-1 OS=Mus musculus GN=Lama1 PE=1 SV=1 PF06008 Laminin Domain I GO:0030155//GO:0030334//GO:0007165//GO:0045995 regulation of cell adhesion//regulation of cell migration//signal transduction//regulation of embryonic development GO:0005102 receptor binding -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.47954 BP_3 664.00 11.60 3051 546677546 ERL88365.1 2277 1.8e-253 hypothetical protein D910_05752 [Dendroctonus ponderosae] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1403 1.7e-153 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF10613//PF00060//PF06816 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//NOTCH protein GO:0006811//GO:0030154//GO:0007268//GO:0007165 ion transport//cell differentiation//synaptic transmission//signal transduction GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.47956 BP_3 3.00 7.19 289 642924557 XP_008194343.1 147 1.7e-07 PREDICTED: zinc finger protein 600-like [Tribolium castaneum]>gi|270006757|gb|EFA03205.1| hypothetical protein TcasGA2_TC013125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07649//PF06397//PF13465//PF00096 C1-like domain//Desulfoferrodoxin, N-terminal domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0055114 oxidation-reduction process GO:0005506//GO:0046872//GO:0047134 iron ion binding//metal ion binding//protein-disulfide reductase activity -- -- -- -- Cluster-8309.47957 BP_3 5.00 2.16 402 642926860 XP_971810.2 171 3.8e-10 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01155//PF13465//PF00096//PF01096//PF00647//PF07649 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Elongation factor 1 gamma, conserved domain//C1-like domain GO:0006448//GO:0006414//GO:0006464//GO:0006351//GO:0055114 regulation of translational elongation//translational elongation//cellular protein modification process//transcription, DNA-templated//oxidation-reduction process GO:0016151//GO:0047134//GO:0046872//GO:0003676//GO:0003746//GO:0008270 nickel cation binding//protein-disulfide reductase activity//metal ion binding//nucleic acid binding//translation elongation factor activity//zinc ion binding GO:0005840 ribosome -- -- Cluster-8309.47958 BP_3 16.65 1.66 774 861591666 KMQ82837.1 178 1.2e-10 integrase core domain protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47959 BP_3 206.61 12.54 1086 642923928 XP_008193931.1 1196 1.5e-128 PREDICTED: probable serine incorporator isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHV9 744 1.6e-77 Serine incorporator 1 OS=Bos taurus GN=SERINC1 PE=2 SV=1 PF03348 Serine incorporator (Serinc) -- -- -- -- GO:0016020 membrane KOG2592 Tumor differentially expressed (TDE) protein Cluster-8309.47960 BP_3 469.75 5.00 4823 478255594 ENN75808.1 232 3.9e-16 hypothetical protein YQE_07644, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86GF7 197 1.8e-13 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.47962 BP_3 211.00 11.10 1208 546673618 ERL85182.1 650 3.3e-65 hypothetical protein D910_02604, partial [Dendroctonus ponderosae] -- -- -- -- -- K00942 E2.7.4.8, gmk guanylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00942 Q64520 527 2.5e-52 Guanylate kinase OS=Mus musculus GN=Guk1 PE=1 SV=2 PF01926//PF06068//PF01695//PF07728//PF08477//PF00004//PF01637//PF03205//PF00005//PF03193//PF00910//PF00485 50S ribosome-binding GTPase//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Molybdopterin guanine dinucleotide synthesis protein B//ABC transporter//Protein of unknown function, DUF258//RNA helicase//Phosphoribulokinase / Uridine kinase family GO:0008152//GO:0006777//GO:0007264 metabolic process//Mo-molybdopterin cofactor biosynthetic process//small GTPase mediated signal transduction GO:0003723//GO:0005524//GO:0003678//GO:0003924//GO:0016887//GO:0016301//GO:0005525//GO:0003724 RNA binding//ATP binding//DNA helicase activity//GTPase activity//ATPase activity//kinase activity//GTP binding//RNA helicase activity GO:0005657 replication fork KOG0707 Guanylate kinase Cluster-8309.47964 BP_3 2.00 0.51 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47965 BP_3 60.61 0.39 7868 642912299 XP_008200639.1 550 8.6e-53 PREDICTED: protein couch potato isoform X1 [Tribolium castaneum] 642912304 XM_008202420.1 250 3.80646e-125 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X4, mRNA -- -- -- -- Q01617 270 1.0e-21 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00168//PF00076 C2 domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.47967 BP_3 241.55 3.07 4087 478252657 ENN73061.1 1798 8.6e-198 hypothetical protein YQE_10331, partial [Dendroctonus ponderosae] -- -- -- -- -- K10770 ALKBH8 alkylated DNA repair protein alkB homolog 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10770 Q07G10 1262 5.0e-137 Alkylated DNA repair protein alkB homolog 8 OS=Xenopus tropicalis GN=alkbh8 PE=2 SV=2 PF01738//PF08241//PF08168//PF04083//PF01209 Dienelactone hydrolase family//Methyltransferase domain//NUC205 domain//Partial alpha/beta-hydrolase lipase region//ubiE/COQ5 methyltransferase family GO:0008152//GO:0006629 metabolic process//lipid metabolic process GO:0008168//GO:0016787 methyltransferase activity//hydrolase activity GO:0005634 nucleus -- -- Cluster-8309.47969 BP_3 2.47 0.59 493 260810939 XP_002600180.1 148 2.2e-07 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47970 BP_3 13.53 3.14 499 260810939 XP_002600180.1 164 3.1e-09 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF00096//PF13465//PF02150 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0008270//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.47971 BP_3 481.34 4.43 5533 642937245 XP_008198754.1 4816 0.0e+00 PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937247|ref|XP_008198755.1| PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937249|ref|XP_008198756.1| PREDICTED: protocadherin-15 [Tribolium castaneum] 817188676 XM_012433497.1 76 1.42244e-28 PREDICTED: Orussus abietinus protocadherin-15 (LOC105704354), mRNA K16500 PCDH15 protocadherin-15 http://www.genome.jp/dbget-bin/www_bget?ko:K16500 Q8BNA6 730 3.3e-75 Protocadherin Fat 3 OS=Mus musculus GN=Fat3 PE=1 SV=2 PF01272//PF00028//PF00041 Transcription elongation factor, GreA/GreB, C-term//Cadherin domain//Fibronectin type III domain GO:0007156//GO:0032784 homophilic cell adhesion via plasma membrane adhesion molecules//regulation of DNA-templated transcription, elongation GO:0005509//GO:0003677//GO:0005515 calcium ion binding//DNA binding//protein binding GO:0016020 membrane -- -- Cluster-8309.47972 BP_3 8524.66 85.45 5100 642937245 XP_008198754.1 6167 0.0e+00 PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937247|ref|XP_008198755.1| PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937249|ref|XP_008198756.1| PREDICTED: protocadherin-15 [Tribolium castaneum] 817188676 XM_012433497.1 76 1.31039e-28 PREDICTED: Orussus abietinus protocadherin-15 (LOC105704354), mRNA K16500 PCDH15 protocadherin-15 http://www.genome.jp/dbget-bin/www_bget?ko:K16500 Q8R508 856 7.5e-90 Protocadherin Fat 3 OS=Rattus norvegicus GN=Fat3 PE=1 SV=1 PF00041//PF00028//PF01272 Fibronectin type III domain//Cadherin domain//Transcription elongation factor, GreA/GreB, C-term GO:0007156//GO:0032784 homophilic cell adhesion via plasma membrane adhesion molecules//regulation of DNA-templated transcription, elongation GO:0003677//GO:0005509//GO:0005515 DNA binding//calcium ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.47975 BP_3 10.55 0.48 1346 229892267 NP_001153545.1 635 2.0e-63 uncharacterized MFS-type transporter [Tribolium castaneum]>gi|270007334|gb|EFA03782.1| hypothetical protein TcasGA2_TC013893 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.47976 BP_3 817.88 5.04 8120 642924482 XP_008194314.1 3729 0.0e+00 PREDICTED: protein ELYS isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U249 903 4.2e-95 Protein ELYS OS=Xenopus laevis GN=ahctf1 PE=1 SV=1 PF05210 Sprouty protein (Spry) GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development -- -- GO:0016020 membrane -- -- Cluster-8309.47978 BP_3 333.82 7.36 2479 270007381 EFA03829.1 1893 5.0e-209 hypothetical protein TcasGA2_TC013944 [Tribolium castaneum] -- -- -- -- -- K19192 SAP130 histone deacetylase complex subunit SAP130 http://www.genome.jp/dbget-bin/www_bget?ko:K19192 Q8BIH0 312 4.4e-27 Histone deacetylase complex subunit SAP130 OS=Mus musculus GN=Sap130 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47979 BP_3 303.26 2.91 5316 407731620 AFU25696.1 4540 0.0e+00 Na+,K+ ATPase alpha-subunit 2, partial [Tetraopes tetrophthalmus] 407731619 JQ771527.1 1269 0 Tetraopes tetrophthalmus Na+,K+ ATPase alpha-subunit 2 mRNA, partial cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 2978 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF04565//PF00122 RNA polymerase Rpb2, domain 3//E1-E2 ATPase GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872//GO:0000166 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//nucleotide binding GO:0005730 nucleolus KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.47983 BP_3 23.33 0.36 3452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47986 BP_3 163.49 3.13 2809 646716704 KDR19844.1 661 4.1e-66 hypothetical protein L798_05910 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W440 592 1.7e-59 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.47988 BP_3 369.95 12.52 1716 91091920 XP_967150.1 2145 2.1e-238 PREDICTED: 60S ribosomal export protein NMD3 [Tribolium castaneum]>gi|270000793|gb|EEZ97240.1| hypothetical protein TcasGA2_TC011038 [Tribolium castaneum] 194768750 XM_001966439.1 63 7.33283e-22 Drosophila ananassae GF21978 (Dana\GF21978), mRNA K07562 NMD3 nonsense-mediated mRNA decay protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07562 Q5BLF0 1487 1.7e-163 60S ribosomal export protein NMD3 OS=Danio rerio GN=nmd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2613 NMD protein affecting ribosome stability and mRNA decay Cluster-8309.47990 BP_3 1050.61 25.85 2251 91085843 XP_974961.1 554 8.4e-54 PREDICTED: protein lunapark [Tribolium castaneum]>gi|270010140|gb|EFA06588.1| hypothetical protein TcasGA2_TC009502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1KKR9 362 6.3e-33 Protein lunapark-B OS=Takifugu rubripes GN=lnpb PE=3 SV=1 PF04689 DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG2846 Predicted membrane protein Cluster-8309.47993 BP_3 81.45 3.21 1513 642921071 XP_008192680.1 188 1.6e-11 PREDICTED: muscle LIM protein Mlp84B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47994 BP_3 33.00 4.70 630 270003490 EEZ99937.1 564 1.6e-55 hypothetical protein TcasGA2_TC002733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DM3 281 4.4e-24 Uncharacterized protein C18orf8 OS=Homo sapiens GN=C18orf8 PE=2 SV=2 PF09280 XPC-binding domain GO:0006281//GO:0043161//GO:0006289 DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair GO:0003684 damaged DNA binding -- -- KOG2377 Uncharacterized conserved protein Cluster-8309.47995 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47997 BP_3 28.97 2.36 883 91087011 XP_974048.1 485 3.3e-46 PREDICTED: uncharacterized protein ZK637.2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0BN94 226 1.5e-17 Protein FAM136A OS=Rattus norvegicus GN=Fam136a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3377 Uncharacterized conserved protein Cluster-8309.47998 BP_3 142.00 5.07 1641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04647 Accessory gene regulator B GO:0009372//GO:0009405 quorum sensing//pathogenesis GO:0008233 peptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47999 BP_3 5.14 0.60 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4800 BP_3 25.49 1.50 1111 270012890 EFA09338.1 480 1.6e-45 hypothetical protein TcasGA2_TC001664 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02884 Polysaccharide lyase family 8, C-terminal beta-sandwich domain -- -- GO:0016829 lyase activity GO:0005576 extracellular region -- -- Cluster-8309.48002 BP_3 6060.00 336.02 1161 114051842 NP_001040431.1 525 1.0e-50 cyclic AMP-regulated protein [Bombyx mori]>gi|95102866|gb|ABF51374.1| cyclic AMP-regulated protein [Bombyx mori] -- -- -- -- -- -- -- -- -- Q14019 309 4.6e-27 Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular -- -- Cluster-8309.48005 BP_3 4.02 0.46 709 189234163 XP_967233.2 348 2.0e-30 PREDICTED: receptor expression-enhancing protein 4-like [Tribolium castaneum] -- -- -- -- -- K17338 REEP1_2_3_4 receptor expression-enhancing protein 1/2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17338 Q5R598 245 7.3e-20 Receptor expression-enhancing protein 4 OS=Pongo abelii GN=REEP4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1726 HVA22/DP1 gene product-related proteins Cluster-8309.48006 BP_3 115.65 2.29 2730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48008 BP_3 475.58 11.60 2268 332375232 AEE62757.1 1178 3.7e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00729 ALG5 dolichyl-phosphate beta-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00729 Q9VLQ1 972 1.2e-103 Dolichyl-phosphate beta-glucosyltransferase OS=Drosophila melanogaster GN=wol PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2977 Glycosyltransferase Cluster-8309.48011 BP_3 124.77 3.29 2119 642915313 XP_008190567.1 2613 1.4e-292 PREDICTED: dosage compensation regulator isoform X1 [Tribolium castaneum] 617490619 XM_007578097.1 253 2.17863e-127 PREDICTED: Poecilia formosa DEAH (Asp-Glu-Ala-His) box helicase 9 (dhx9), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1880 5.7e-209 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF04408 Helicase associated domain (HA2) -- -- GO:0004386 helicase activity -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.48012 BP_3 37.00 0.61 3202 91088947 XP_973771.1 2775 2.5e-311 PREDICTED: exocyst complex component 3 [Tribolium castaneum]>gi|270012371|gb|EFA08819.1| hypothetical protein TcasGA2_TC006514 [Tribolium castaneum] -- -- -- -- -- K06110 EXOC3, SEC6L1 exocyst complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06110 Q9V8K2 1730 2.1e-191 Exocyst complex component 3 OS=Drosophila melanogaster GN=sec6 PE=2 SV=2 PF05192//PF03283//PF06046 MutS domain III//Pectinacetylesterase//Exocyst complex component Sec6 GO:0006298//GO:0006887 mismatch repair//exocytosis GO:0005524//GO:0030983//GO:0016787 ATP binding//mismatched DNA binding//hydrolase activity GO:0000145 exocyst KOG2286 Exocyst complex subunit SEC6 Cluster-8309.48013 BP_3 193.41 23.58 687 642926077 XP_971220.2 626 1.1e-62 PREDICTED: 39S ribosomal protein L18, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02881 RP-L18, MRPL18, rplR large subunit ribosomal protein L18 http://www.genome.jp/dbget-bin/www_bget?ko:K02881 Q9H0U6 244 9.3e-20 39S ribosomal protein L18, mitochondrial OS=Homo sapiens GN=MRPL18 PE=1 SV=1 PF00861 Ribosomal L18p/L5e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3333 Mitochondrial/chloroplast ribosomal protein L18 Cluster-8309.48017 BP_3 275.04 5.90 2540 642931650 XP_008196671.1 163 2.1e-08 PREDICTED: death-associated protein kinase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5D014 143 1.8e-07 Protein NATD1 OS=Danio rerio GN=natd1 PE=3 SV=1 PF04558//PF00583//PF13508 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967//GO:0006418 acyl-carrier-protein biosynthetic process//tRNA aminoacylation for protein translation GO:0004812//GO:0008080//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//N-acetyltransferase activity//ATP binding//nucleotide binding GO:0005737 cytoplasm -- -- Cluster-8309.48019 BP_3 167.63 3.31 2732 642929013 XP_008195655.1 1308 3.8e-141 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Tribolium castaneum] 759111195 XM_011357078.1 54 1.18402e-16 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K06125 COQ2 4-hydroxybenzoate polyprenyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06125 Q16QL3 1096 6.0e-118 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Aedes aegypti GN=coq2 PE=3 SV=1 PF01040//PF02366 UbiA prenyltransferase family//Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0006493 protein O-linked glycosylation GO:0004659//GO:0000030 prenyltransferase activity//mannosyltransferase activity GO:0000136//GO:0016020//GO:0016021 alpha-1,6-mannosyltransferase complex//membrane//integral component of membrane KOG1381 Para-hydroxybenzoate-polyprenyl transferase Cluster-8309.48022 BP_3 5.93 0.36 1090 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48024 BP_3 81.49 0.83 5015 270010959 EFA07407.1 2173 3.5e-241 protein C kinase 98E-like protein [Tribolium castaneum] 817193422 XM_012416747.1 273 3.966e-138 PREDICTED: Orussus abietinus protein kinase C (LOC105695297), transcript variant X5, mRNA K18050 PRKCE novel protein kinase C epsilon type http://www.genome.jp/dbget-bin/www_bget?ko:K18050 P13678 1797 5.7e-199 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF07714//PF07649//PF00628//PF00069//PF00168//PF00433//PF06293 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein tyrosine kinase//C1-like domain//PHD-finger//Protein kinase domain//C2 domain//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009069//GO:0006468//GO:0016310//GO:0055114//GO:0035556 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0016773//GO:0047134//GO:0004672//GO:0004674 ATP binding//protein binding//phosphotransferase activity, alcohol group as acceptor//protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.48026 BP_3 901.54 8.66 5312 546680410 ERL90676.1 3620 0.0e+00 hypothetical protein D910_08023 [Dendroctonus ponderosae] 827559853 XM_012695450.1 81 2.26844e-31 PREDICTED: Bombyx mori active breakpoint cluster region-related protein (LOC101736460), transcript variant X3, mRNA -- -- -- -- Q6PAJ1 1290 3.7e-140 Breakpoint cluster region protein OS=Mus musculus GN=Bcr PE=1 SV=3 PF00621//PF07247//PF09036//PF00620//PF00168 RhoGEF domain//Alcohol acetyltransferase//Bcr-Abl oncoprotein oligomerisation domain//RhoGAP domain//C2 domain GO:0043087//GO:0035023//GO:0007165//GO:0042967//GO:0016310//GO:0006066//GO:0009069//GO:0006468 regulation of GTPase activity//regulation of Rho protein signal transduction//signal transduction//acyl-carrier-protein biosynthetic process//phosphorylation//alcohol metabolic process//serine family amino acid metabolic process//protein phosphorylation GO:0004026//GO:0004674//GO:0005089//GO:0005096//GO:0005515 alcohol O-acetyltransferase activity//protein serine/threonine kinase activity//Rho guanyl-nucleotide exchange factor activity//GTPase activator activity//protein binding -- -- -- -- Cluster-8309.48028 BP_3 295.55 3.45 4424 642921136 XP_008192702.1 1068 4.1e-113 PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921138|ref|XP_008192703.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921140|ref|XP_008192704.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921142|ref|XP_008192706.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921144|ref|XP_008192707.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921146|ref|XP_008192708.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921148|ref|XP_008192709.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921150|ref|XP_008192710.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WVB4 224 1.3e-16 Slit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2 PF13855//PF13895//PF15050//PF14991 Leucine rich repeat//Immunoglobulin domain//SCIMP protein//Protein melan-A -- -- GO:0005515 protein binding GO:0016021//GO:0001772//GO:0042470//GO:0097197 integral component of membrane//immunological synapse//melanosome//tetraspanin-enriched microdomain -- -- Cluster-8309.48029 BP_3 110.39 2.72 2251 478263729 ENN82032.1 1745 6.6e-192 hypothetical protein YQE_01607, partial [Dendroctonus ponderosae] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 B7ZMP1 1042 9.0e-112 Probable Xaa-Pro aminopeptidase 3 OS=Mus musculus GN=Xpnpep3 PE=2 SV=1 PF05195 Aminopeptidase P, N-terminal domain -- -- GO:0004177//GO:0030145 aminopeptidase activity//manganese ion binding -- -- KOG2414 Putative Xaa-Pro aminopeptidase Cluster-8309.48033 BP_3 372.99 12.34 1749 478260919 ENN80542.1 1144 2.5e-122 hypothetical protein YQE_03036, partial [Dendroctonus ponderosae]>gi|546684164|gb|ERL93869.1| hypothetical protein D910_11155 [Dendroctonus ponderosae] -- -- -- -- -- K11687 ADPRHL2 poly(ADP-ribose) glycohydrolase ARH3 http://www.genome.jp/dbget-bin/www_bget?ko:K11687 Q8CG72 584 8.9e-59 Poly(ADP-ribose) glycohydrolase ARH3 OS=Mus musculus GN=Adprhl2 PE=1 SV=1 PF01051 Initiator Replication protein GO:0006260//GO:0006270 DNA replication//DNA replication initiation GO:0003887 DNA-directed DNA polymerase activity GO:0005727//GO:0042575 extrachromosomal circular DNA//DNA polymerase complex -- -- Cluster-8309.48036 BP_3 1014.04 24.91 2254 478251961 ENN72399.1 2164 1.7e-240 hypothetical protein YQE_11033, partial [Dendroctonus ponderosae] -- -- -- -- -- K01412 PMPCA, MAS2 mitochondrial-processing peptidase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01412 Q0P5M8 1272 1.9e-138 Mitochondrial-processing peptidase subunit alpha OS=Bos taurus GN=PMPCA PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2067 Mitochondrial processing peptidase, alpha subunit Cluster-8309.48039 BP_3 382.36 3.96 4943 642915162 XP_008190500.1 1220 1.1e-130 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07283 146 1.6e-07 Trichohyalin OS=Homo sapiens GN=TCHH PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48040 BP_3 68.28 0.76 4642 642915162 XP_008190500.1 1424 2.3e-154 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02562 149 6.5e-08 Myosin heavy chain, skeletal muscle (Fragments) OS=Oryctolagus cuniculus PE=1 SV=2 PF02135 TAZ zinc finger GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0008270//GO:0003712//GO:0004402 zinc ion binding//transcription cofactor activity//histone acetyltransferase activity GO:0000123//GO:0005667//GO:0005634 histone acetyltransferase complex//transcription factor complex//nucleus -- -- Cluster-8309.48042 BP_3 86.08 3.54 1465 270014289 EFA10737.1 225 7.7e-16 armadillo-1 [Tribolium castaneum] 642934620 XM_008199519.1 68 1.03647e-24 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 Q17GS9 128 5.6e-06 Armadillo segment polarity protein OS=Aedes aegypti GN=arm PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48043 BP_3 164.41 6.48 1515 270014289 EFA10737.1 642 3.5e-64 armadillo-1 [Tribolium castaneum] 642934620 XM_008199519.1 158 9.9944e-75 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 430 5.6e-41 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48044 BP_3 242.00 70.41 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48046 BP_3 28.26 0.34 4241 642918882 XP_008191626.1 256 5.7e-19 PREDICTED: E3 ubiquitin-protein ligase TRIM33-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01399 PCI domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48047 BP_3 287.93 9.62 1735 642923022 XP_008200499.1 968 6.4e-102 PREDICTED: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62377 498 8.3e-49 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 OS=Mus musculus GN=Zrsr2 PE=2 SV=1 PF00076//PF00642 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- KOG2202 U2 snRNP splicing factor, small subunit, and related proteins Cluster-8309.48048 BP_3 763.00 188.12 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48049 BP_3 34.56 0.35 5021 270014603 EFA11051.1 2395 6.3e-267 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] 195445683 XM_002070402.1 103 1.26286e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 1737 5.1e-192 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00041//PF00102//PF00782 Fibronectin type III domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0005515//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.4805 BP_3 24.17 0.47 2796 642927615 XP_008195335.1 1656 1.7e-181 PREDICTED: ribosomal protein S6 kinase delta-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R2S1 381 4.9e-35 Ribosomal protein S6 kinase-like 1 OS=Mus musculus GN=Rps6kl1 PE=1 SV=1 PF00787//PF00069//PF07714//PF13374//PF13181//PF00515//PF13414 PX domain//Protein kinase domain//Protein tyrosine kinase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0006468 protein phosphorylation GO:0005515//GO:0035091//GO:0004672//GO:0005524 protein binding//phosphatidylinositol binding//protein kinase activity//ATP binding -- -- -- -- Cluster-8309.48050 BP_3 369.00 6.39 3073 189234519 XP_001813478.1 630 1.8e-62 PREDICTED: BRISC complex subunit Abro1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TCJ1 271 3.1e-22 BRISC complex subunit Abro1 OS=Mus musculus GN=Fam175b PE=2 SV=1 PF09162 Tap, RNA-binding GO:0006406 mRNA export from nucleus GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.48053 BP_3 939.93 9.49 5067 91082203 XP_972014.1 3609 0.0e+00 PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922206|ref|XP_008193062.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922209|ref|XP_008193063.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|270007229|gb|EFA03677.1| hypothetical protein TcasGA2_TC013779 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02466 665 1.0e-67 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF07714//PF03139//PF00069//PF05676 Protein tyrosine kinase//Vanadium/alternative nitrogenase delta subunit//Protein kinase domain//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GO:0015992//GO:0055114//GO:0006118//GO:0006814//GO:0006468//GO:0009399//GO:0006120//GO:0006807//GO:0006744//GO:0016310//GO:0019337 proton transport//oxidation-reduction process//obsolete electron transport//sodium ion transport//protein phosphorylation//nitrogen fixation//mitochondrial electron transport, NADH to ubiquinone//nitrogen compound metabolic process//ubiquinone biosynthetic process//phosphorylation//tetrachloroethylene catabolic process GO:0016163//GO:0008137//GO:0000166//GO:0005524//GO:0004672//GO:0003954 nitrogenase activity//NADH dehydrogenase (ubiquinone) activity//nucleotide binding//ATP binding//protein kinase activity//NADH dehydrogenase activity GO:0016610//GO:0005739 nitrogenase complex//mitochondrion KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.48055 BP_3 98.96 1.10 4628 642936421 XP_008198427.1 2180 4.9e-242 PREDICTED: 5-hydroxytryptamine receptor 1 [Tribolium castaneum] 827537400 XM_012691584.1 74 1.5371e-27 PREDICTED: Bombyx mori 5-hydroxytryptamine receptor 1-like (LOC101742917), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 P20905 1148 9.4e-124 5-hydroxytryptamine receptor 1 OS=Drosophila melanogaster GN=5-HT7 PE=2 SV=1 PF12822//PF06072//PF00001//PF03839 Protein of unknown function (DUF3816)//Alphaherpesvirus tegument protein US9//7 transmembrane receptor (rhodopsin family)//Translocation protein Sec62 GO:0015031//GO:0007186//GO:0006810 protein transport//G-protein coupled receptor signaling pathway//transport GO:0008565//GO:0005215//GO:0004930 protein transporter activity//transporter activity//G-protein coupled receptor activity GO:0019033//GO:0016021 viral tegument//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.48057 BP_3 29.42 0.53 2982 91088439 XP_968151.1 419 5.0e-38 PREDICTED: uncharacterized protein LOC656533 [Tribolium castaneum]>gi|270011749|gb|EFA08197.1| hypothetical protein TcasGA2_TC005824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48058 BP_3 581.49 9.13 3360 189235679 XP_971393.2 409 8.2e-37 PREDICTED: sperm surface protein Sp17 [Tribolium castaneum]>gi|270004446|gb|EFA00894.1| hypothetical protein TcasGA2_TC003798 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48060 BP_3 60.00 1.68 2018 -- -- -- -- -- 56044569 AC152925.1 37 2.45667e-07 Tribolium castaneum BAC T.cast_C17P12 (Clemson University Genomics Institute Tribolium castaneum BAC Library (Red Flour Beetle)) complete sequence -- -- -- -- -- -- -- -- PF01273 LBP / BPI / CETP family, N-terminal domain -- -- GO:0008289 lipid binding -- -- -- -- Cluster-8309.48062 BP_3 960.42 16.47 3103 91091282 XP_966431.1 2214 3.8e-246 PREDICTED: rab5 GDP/GTP exchange factor isoform X1 [Tribolium castaneum]>gi|270013085|gb|EFA09533.1| hypothetical protein TcasGA2_TC011637 [Tribolium castaneum] 642936531 XM_970650.3 233 4.20535e-116 PREDICTED: Tribolium castaneum rab5 GDP/GTP exchange factor (LOC658256), transcript variant X2, mRNA -- -- -- -- Q9JM13 745 3.4e-77 Rab5 GDP/GTP exchange factor OS=Mus musculus GN=Rabgef1 PE=1 SV=1 PF01754 A20-like zinc finger -- -- GO:0003677//GO:0005488//GO:0008270 DNA binding//binding//zinc ion binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.48064 BP_3 567.88 9.10 3298 642914971 XP_008190464.1 2176 1.0e-241 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 1.41247e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 392 3.1e-36 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF00322//PF01585//PF07823//PF01805//PF06703 Endothelin family//G-patch domain//Cyclic phosphodiesterase-like protein//Surp module//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0019229//GO:0006465//GO:0006396 regulation of vasoconstriction//signal peptide processing//RNA processing GO:0003723//GO:0008233//GO:0003676//GO:0004112 RNA binding//peptidase activity//nucleic acid binding//cyclic-nucleotide phosphodiesterase activity GO:0016021//GO:0005787//GO:0005576 integral component of membrane//signal peptidase complex//extracellular region -- -- Cluster-8309.48065 BP_3 141.70 2.37 3177 642914971 XP_008190464.1 1011 1.2e-106 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 1.36008e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 392 3.0e-36 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF01585//PF00322//PF06703//PF05680 G-patch domain//Endothelin family//Microsomal signal peptidase 25 kDa subunit (SPC25)//ATP synthase E chain GO:0006465//GO:0019229//GO:0015986//GO:0015992 signal peptide processing//regulation of vasoconstriction//ATP synthesis coupled proton transport//proton transport GO:0015078//GO:0003676//GO:0008233 hydrogen ion transmembrane transporter activity//nucleic acid binding//peptidase activity GO:0016021//GO:0000276//GO:0005576//GO:0005787 integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//extracellular region//signal peptidase complex -- -- Cluster-8309.48066 BP_3 221.34 10.09 1349 478256079 ENN76278.1 720 2.8e-73 hypothetical protein YQE_07242, partial [Dendroctonus ponderosae]>gi|546676009|gb|ERL87104.1| hypothetical protein D910_04504 [Dendroctonus ponderosae] 617638670 XM_007531235.1 50 9.65961e-15 PREDICTED: Erinaceus europaeus oligosaccharyltransferase complex subunit (non-catalytic) (OSTC), mRNA K17259 CIB1 calcium and integrin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17259 Q17QE5 381 2.4e-35 Calcium and integrin-binding protein 1 OS=Bos taurus GN=CIB1 PE=2 SV=1 PF12763//PF13202//PF13499//PF10591//PF13833//PF13405//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0038 Ca2+-binding kinase interacting protein (KIP) (EF-Hand protein superfamily) Cluster-8309.48069 BP_3 19.26 0.43 2450 642919794 XP_008192070.1 1773 4.1e-195 PREDICTED: coronin-7 isoform X1 [Tribolium castaneum]>gi|270005922|gb|EFA02370.1| hypothetical protein TcasGA2_TC008045 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q0V8F1 688 1.1e-70 Coronin-7 OS=Bos taurus GN=CORO7 PE=2 SV=1 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.48071 BP_3 108.00 0.96 5730 642914658 XP_008190303.1 1363 3.3e-147 PREDICTED: glycine N-acyltransferase [Tribolium castaneum]>gi|270001445|gb|EEZ97892.1| hypothetical protein TcasGA2_TC000274 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13302//PF13673//PF08445//PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.48072 BP_3 202.00 6.12 1882 91090214 XP_967924.1 1392 4.7e-151 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 588 3.3e-59 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.48075 BP_3 18.82 3.39 559 157127404 XP_001654963.1 398 2.6e-36 AAEL002228-PA [Aedes aegypti]>gi|108882398|gb|EAT46623.1| AAEL002228-PA [Aedes aegypti] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 337 1.2e-30 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- GO:0003824 catalytic activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48077 BP_3 74.00 9.74 658 478252126 ENN72557.1 261 2.3e-20 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48078 BP_3 7.00 0.39 1164 478252125 ENN72556.1 744 4.0e-76 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 519 2.0e-51 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48081 BP_3 2.00 47.55 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.48082 BP_3 2.00 6.24 279 646714789 KDR18643.1 178 4.1e-11 hypothetical protein L798_06624, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48085 BP_3 2.00 0.69 431 755966256 XP_011305442.1 367 7.8e-33 PREDICTED: fatty acid synthase-like [Fopius arisanus]>gi|755966259|ref|XP_011305443.1| PREDICTED: fatty acid synthase-like [Fopius arisanus] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 284 1.3e-24 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48086 BP_3 5.66 0.59 752 641675408 XP_008187029.1 708 3.9e-72 PREDICTED: fatty acid synthase [Acyrthosiphon pisum]>gi|641675410|ref|XP_008187030.1| PREDICTED: fatty acid synthase [Acyrthosiphon pisum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 599 7.0e-61 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48087 BP_3 99.60 1.34 3881 645008238 XP_008203901.1 1419 7.2e-154 PREDICTED: fatty acid synthase-like [Nasonia vitripennis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 1101 2.2e-118 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00107//PF00106//PF14604//PF00975//PF00018 Zinc-binding dehydrogenase//short chain dehydrogenase//Variant SH3 domain//Thioesterase domain//SH3 domain GO:0055114//GO:0009058//GO:0008152 oxidation-reduction process//biosynthetic process//metabolic process GO:0005515//GO:0016491//GO:0016788 protein binding//oxidoreductase activity//hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48088 BP_3 3.00 2.63 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48091 BP_3 1.00 0.43 402 546676979 ERL87903.1 440 2.5e-41 hypothetical protein D910_05291 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 405 1.2e-38 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48095 BP_3 206.91 32.45 599 478252126 ENN72557.1 280 1.3e-22 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48096 BP_3 4.06 3.97 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48097 BP_3 20.90 7.35 428 827552646 XP_012548082.1 413 3.6e-38 PREDICTED: LOW QUALITY PROTEIN: p270 isoform X1 [Bombyx mori] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 369 1.9e-34 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.481 BP_3 38.91 3.22 875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48100 BP_3 5.00 11.68 290 641675408 XP_008187029.1 225 1.5e-16 PREDICTED: fatty acid synthase [Acyrthosiphon pisum]>gi|641675410|ref|XP_008187030.1| PREDICTED: fatty acid synthase [Acyrthosiphon pisum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 168 2.5e-11 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF10174 RIM-binding protein of the cytomatrix active zone -- -- -- -- GO:0048786 presynaptic active zone KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48101 BP_3 23.04 2.67 708 478252126 ENN72557.1 282 9.2e-23 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48107 BP_3 244.06 2.49 5015 91085385 XP_966386.1 455 5.7e-42 PREDICTED: arginine/serine-rich coiled-coil protein 2 [Tribolium castaneum]>gi|270009149|gb|EFA05597.1| hypothetical protein TcasGA2_TC015801 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHJ5 200 8.6e-14 Arginine/serine-rich coiled-coil protein 2 OS=Xenopus tropicalis GN=rsrc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48108 BP_3 814.16 15.61 2805 91093897 XP_969153.1 2630 2.0e-294 PREDICTED: tyrosine-protein kinase shark [Tribolium castaneum]>gi|270014537|gb|EFA10985.1| hypothetical protein TcasGA2_TC004153 [Tribolium castaneum] -- -- -- -- -- K17512 SHARK tyrosine-protein kinase shark  http://www.genome.jp/dbget-bin/www_bget?ko:K17512 P53356 785 7.1e-82 Tyrosine-protein kinase HTK16 OS=Hydra vulgaris GN=HTK16 PE=2 SV=1 PF00023//PF00069//PF13606//PF07714 Ankyrin repeat//Protein kinase domain//Ankyrin repeat//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0004713 protein binding//protein kinase activity//ATP binding//protein tyrosine kinase activity -- -- -- -- Cluster-8309.48109 BP_3 52.84 1.30 2258 91093897 XP_969153.1 1901 5.4e-210 PREDICTED: tyrosine-protein kinase shark [Tribolium castaneum]>gi|270014537|gb|EFA10985.1| hypothetical protein TcasGA2_TC004153 [Tribolium castaneum] -- -- -- -- -- K17512 SHARK tyrosine-protein kinase shark  http://www.genome.jp/dbget-bin/www_bget?ko:K17512 Q24145 780 2.2e-81 Tyrosine-protein kinase shark OS=Drosophila melanogaster GN=shark PE=2 SV=2 PF00069//PF00023//PF07714//PF13606 Protein kinase domain//Ankyrin repeat//Protein tyrosine kinase//Ankyrin repeat GO:0006468//GO:0016310 protein phosphorylation//phosphorylation GO:0004672//GO:0005515//GO:0000166//GO:0005524 protein kinase activity//protein binding//nucleotide binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.48110 BP_3 849.60 11.72 3787 91079594 XP_967887.1 1746 8.5e-192 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X1 [Tribolium castaneum]>gi|270003396|gb|EEZ99843.1| hypothetical protein TcasGA2_TC002624 [Tribolium castaneum] 194884182 XM_001976139.1 162 1.51328e-76 Drosophila erecta GG22721 (Dere\GG22721), mRNA K11975 RNF144 E3 ubiquitin-protein ligase RNF144 http://www.genome.jp/dbget-bin/www_bget?ko:K11975 Q925F3 770 5.2e-80 E3 ubiquitin-protein ligase RNF144A OS=Mus musculus GN=Rnf144a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.48112 BP_3 135.55 35.40 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48115 BP_3 31.72 4.63 622 195432162 XP_002064095.1 211 1.4e-14 GK19985 [Drosophila willistoni]>gi|194160180|gb|EDW75081.1| GK19985 [Drosophila willistoni] -- -- -- -- -- K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 -- -- -- -- PF03051 Peptidase C1-like family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.48118 BP_3 14.69 1.11 928 817053041 XP_012259845.1 528 3.6e-51 PREDICTED: insulin-like receptor [Athalia rosae] -- -- -- -- -- K04527 INSR insulin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04527 O02466 403 4.6e-38 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF00757 Furin-like cysteine rich region GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0004714 ATP binding//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.48119 BP_3 181.36 2.27 4146 91084075 XP_967986.1 1341 8.6e-145 PREDICTED: regucalcin [Tribolium castaneum]>gi|270006685|gb|EFA03133.1| hypothetical protein TcasGA2_TC013045 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I923 524 1.9e-51 Regucalcin OS=Gallus gallus GN=RGN PE=2 SV=1 -- -- GO:0050790 regulation of catalytic activity GO:0030234//GO:0005509 enzyme regulator activity//calcium ion binding -- -- -- -- Cluster-8309.48121 BP_3 1574.15 22.51 3663 642918801 XP_008191591.1 1384 7.8e-150 PREDICTED: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [Tribolium castaneum]>gi|270005684|gb|EFA02132.1| hypothetical protein TcasGA2_TC007781 [Tribolium castaneum] -- -- -- -- -- K13514 LPGAT1 lysophosphatidylglycerol acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13514 Q92604 758 1.2e-78 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Homo sapiens GN=LPGAT1 PE=1 SV=1 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.48122 BP_3 94.67 1.71 2964 478261325 ENN80741.1 3369 0.0e+00 hypothetical protein YQE_02849, partial [Dendroctonus ponderosae] 759040950 XM_011330978.1 45 1.29504e-11 PREDICTED: Cerapachys biroi UPF0378 protein KIAA0100 (LOC105274669), transcript variant X2, mRNA -- -- -- -- Q5SYL3 1379 9.9e-151 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=2 SV=1 PF02601 Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG1910 Uncharacterized conserved protein Cluster-8309.48123 BP_3 77.08 4.73 1077 642933143 XP_008197274.1 1612 8.4e-177 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14667 735 1.7e-76 Protein KIAA0100 OS=Homo sapiens GN=KIAA0100 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1910 Uncharacterized conserved protein Cluster-8309.48124 BP_3 2.00 0.78 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48126 BP_3 200.00 5.51 2041 -- -- -- -- -- 85822206 DQ295882.1 47 6.86098e-13 Glossina morsitans morsitans prophenol oxidase activating enzyme precursor protein (PPAE) mRNA, complete cds -- -- -- -- -- -- -- -- PF13631 Cytochrome b(N-terminal)/b6/petB GO:0006118 obsolete electron transport GO:0009055//GO:0016491 electron carrier activity//oxidoreductase activity GO:0016020 membrane -- -- Cluster-8309.48127 BP_3 50.00 3.21 1042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48129 BP_3 18.00 3.99 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48131 BP_3 62.13 0.45 6977 270014943 EFA11391.1 3101 0.0e+00 hypothetical protein TcasGA2_TC011551 [Tribolium castaneum] 642910356 XM_008202069.1 422 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 1743 1.4e-192 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.48134 BP_3 182.00 6.18 1712 817208960 XP_012280514.1 1282 2.5e-138 PREDICTED: glycoprotein endo-alpha-1,2-mannosidase [Orussus abietinus] -- -- -- -- -- K15538 MANEA glycoprotein endo-alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K15538 Q5GF25 916 2.8e-97 Glycoprotein endo-alpha-1,2-mannosidase OS=Rattus norvegicus GN=Manea PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48135 BP_3 30.85 0.67 2526 642936826 XP_008197806.1 2492 1.8e-278 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1 [Tribolium castaneum]>gi|270000937|gb|EEZ97384.1| hypothetical protein TcasGA2_TC011210 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 1889 6.1e-210 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00628//PF00622//PF00130 PHD-finger//SPRY domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.48137 BP_3 236.01 11.81 1255 546676804 ERL87750.1 647 7.7e-65 hypothetical protein D910_05139 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 B4F753 267 3.7e-22 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF00975//PF01764//PF02230//PF07859//PF14993 Thioesterase domain//Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Neuropeptide S precursor protein GO:0009058//GO:0006629//GO:0007218//GO:0008152 biosynthetic process//lipid metabolic process//neuropeptide signaling pathway//metabolic process GO:0016787//GO:0016788 hydrolase activity//hydrolase activity, acting on ester bonds GO:0005576 extracellular region -- -- Cluster-8309.48139 BP_3 57.91 4.89 863 642931770 XP_008196721.1 672 6.7e-68 PREDICTED: cytohesin-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q9QX11 460 1.1e-44 Cytohesin-1 OS=Mus musculus GN=Cyth1 PE=1 SV=2 PF01466//PF01369 Skp1 family, dimerisation domain//Sec7 domain GO:0043087//GO:0006511//GO:0032012 regulation of GTPase activity//ubiquitin-dependent protein catabolic process//regulation of ARF protein signal transduction GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.48140 BP_3 114.04 2.80 2255 642931766 XP_008196719.1 2049 3.7e-227 PREDICTED: cytohesin-1 isoform X2 [Tribolium castaneum] 676429235 XM_009047286.1 185 1.46768e-89 Lottia gigantea hypothetical protein partial mRNA K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q15438 1356 3.5e-148 Cytohesin-1 OS=Homo sapiens GN=CYTH1 PE=1 SV=1 PF01369//PF11525 Sec7 domain//Copper resistance protein K GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086//GO:0046872 ARF guanyl-nucleotide exchange factor activity//metal ion binding -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.48143 BP_3 642.79 7.40 4476 478258212 ENN78341.1 2330 1.9e-259 hypothetical protein YQE_05143, partial [Dendroctonus ponderosae]>gi|546677008|gb|ERL87924.1| hypothetical protein D910_05312 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R7U0 1006 2.7e-107 Transmembrane channel-like protein 7 OS=Macaca fascicularis GN=TMC7 PE=2 SV=1 PF08686//PF07810//PF16794 PLAC (protease and lacunin) domain//TMC domain//Fibronectin-III type domain -- -- GO:0008233//GO:0005515 peptidase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.48144 BP_3 241.59 2.07 5910 642929812 XP_008195986.1 1599 1.5e-174 PREDICTED: myb-related protein B isoform X2 [Tribolium castaneum] 817200908 XM_012420764.1 89 9.01947e-36 PREDICTED: Orussus abietinus myb-related protein B (LOC105697441), transcript variant X2, mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 P01103 467 1.1e-44 Transcriptional activator Myb OS=Gallus gallus GN=MYB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0048 Transcription factor, Myb superfamily Cluster-8309.48145 BP_3 472.92 4.68 5160 642929812 XP_008195986.1 1980 8.5e-219 PREDICTED: myb-related protein B isoform X2 [Tribolium castaneum] 657582350 XM_008297008.1 122 3.55842e-54 PREDICTED: Stegastes partitus v-myb avian myeloblastosis viral oncogene homolog (myb), mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 Q08759 683 8.7e-70 Transcriptional activator Myb OS=Xenopus laevis GN=myb PE=2 SV=1 PF16517//PF09111 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain//SLIDE GO:0007165//GO:0006338 signal transduction//chromatin remodeling GO:0003676//GO:0005524//GO:0016818 nucleic acid binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0048 Transcription factor, Myb superfamily Cluster-8309.48147 BP_3 50.00 55.98 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4815 BP_3 2.00 0.78 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48150 BP_3 14.83 0.82 1167 642914188 XP_008201581.1 392 2.7e-35 PREDICTED: uncharacterized protein LOC661670 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.48152 BP_3 24.00 24.27 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48156 BP_3 74.00 7.57 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48160 BP_3 38.78 1.29 1745 755939885 XP_011297929.1 794 9.7e-82 PREDICTED: NHS-like protein 1 isoform X1 [Fopius arisanus] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 Q9R062 762 2.0e-79 Glycogenin-1 OS=Mus musculus GN=Gyg1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.48161 BP_3 4.00 0.90 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48165 BP_3 74.12 3.34 1362 546679304 ERL89791.1 571 5.4e-56 hypothetical protein D910_07152 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03188 Eukaryotic cytochrome b561 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48166 BP_3 5.00 0.56 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48167 BP_3 3.11 0.34 730 642936857 XP_008197925.1 328 4.4e-28 PREDICTED: protein LMBR1L isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D1E5 231 3.2e-18 Protein LMBR1L OS=Mus musculus GN=Lmbr1l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.48169 BP_3 9.12 4.48 388 546675359 ERL86569.1 333 6.1e-29 hypothetical protein D910_03976 [Dendroctonus ponderosae] -- -- -- -- -- K12345 SRD5A3 3-oxo-5-alpha-steroid 4-dehydrogenase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12345 Q9VLP9 204 2.3e-15 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG1640 Predicted steroid reductase Cluster-8309.48171 BP_3 99.28 0.57 8619 642939376 XP_008193155.1 2929 0.0e+00 PREDICTED: uncharacterized protein LOC660515 isoform X1 [Tribolium castaneum] 642939377 XM_008194938.1 113 6.0003e-49 PREDICTED: Tribolium castaneum hemicentin-1 (LOC660515), transcript variant X2, mRNA -- -- -- -- Q8WZ42 332 7.3e-29 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF13895//PF06377//PF00895//PF05510 Immunoglobulin domain//Adipokinetic hormone//ATP synthase protein 8//Sarcoglycan alpha/epsilon GO:0007165//GO:0015992//GO:0015986 signal transduction//proton transport//ATP synthesis coupled proton transport GO:0005515//GO:0005179//GO:0015078 protein binding//hormone activity//hydrogen ion transmembrane transporter activity GO:0016012//GO:0000276 sarcoglycan complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.48177 BP_3 82.77 4.35 1209 642913075 XP_008201379.1 1055 3.6e-112 PREDICTED: disks large 1 tumor suppressor protein isoform X3 [Tribolium castaneum] 642913074 XM_008203157.1 285 1.99642e-145 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X3, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 354 2.9e-32 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.48179 BP_3 43.06 2.08 1290 642919433 XP_008191867.1 799 1.9e-82 PREDICTED: uncharacterized protein LOC663349 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48182 BP_3 656.73 4.24 7752 91080495 XP_971019.1 7430 0.0e+00 PREDICTED: ectopic P granules protein 5 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IEK6 2377 4.9e-266 Ectopic P granules protein 5 homolog OS=Aedes aegypti GN=AAEL009648 PE=3 SV=1 PF12422//PF05493 Condensin II non structural maintenance of chromosomes subunit//ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0005634//GO:0033179 nucleus//proton-transporting V-type ATPase, V0 domain KOG3622 Uncharacterized conserved protein Cluster-8309.48183 BP_3 112.12 1.19 4841 270005308 EFA01756.1 572 1.5e-55 hypothetical protein TcasGA2_TC007354 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- -- -- Cluster-8309.48185 BP_3 801.28 16.30 2661 642921967 XP_008192964.1 947 2.7e-99 PREDICTED: protein painting of fourth isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W123 294 5.8e-25 Protein painting of fourth OS=Drosophila melanogaster GN=Pof PE=1 SV=1 PF00076//PF01757 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Acyltransferase family -- -- GO:0016747//GO:0003676 transferase activity, transferring acyl groups other than amino-acyl groups//nucleic acid binding -- -- -- -- Cluster-8309.48186 BP_3 19.62 1.00 1235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48188 BP_3 640.55 4.69 6877 478249793 ENN70300.1 1026 4.8e-108 hypothetical protein YQE_12811, partial [Dendroctonus ponderosae] 642934382 XM_962183.2 94 1.74455e-38 PREDICTED: Tribolium castaneum fibroblast growth factor receptor-like 1 (LOC655623), mRNA K15279 SLC35C1, FUCT1 solute carrier family 35 (GDP-fucose transporter), member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K15279 Q9VHT4 606 9.9e-61 GDP-fucose transporter 1 OS=Drosophila melanogaster GN=nac PE=1 SV=1 PF03121//PF03030//PF13895//PF00892//PF06667 Herpesviridae UL52/UL70 DNA primase//Inorganic H+ pyrophosphatase//Immunoglobulin domain//EamA-like transporter family//Phage shock protein B GO:0015992//GO:0006355//GO:0006269//GO:0006260//GO:0006119//GO:0006351//GO:0009271 proton transport//regulation of transcription, DNA-templated//DNA replication, synthesis of RNA primer//DNA replication//oxidative phosphorylation//transcription, DNA-templated//phage shock GO:0005515//GO:0009678//GO:0004427//GO:0003896 protein binding//hydrogen-translocating pyrophosphatase activity//inorganic diphosphatase activity//DNA primase activity GO:0005730//GO:0016020//GO:0016021//GO:0005657 nucleolus//membrane//integral component of membrane//replication fork KOG1442 GDP-fucose transporter Cluster-8309.48189 BP_3 149.40 6.72 1363 478249807 ENN70314.1 757 1.5e-77 hypothetical protein YQE_12825, partial [Dendroctonus ponderosae]>gi|546682872|gb|ERL92758.1| hypothetical protein D910_10067 [Dendroctonus ponderosae] -- -- -- -- -- K15279 SLC35C1, FUCT1 solute carrier family 35 (GDP-fucose transporter), member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K15279 Q9VHT4 484 2.7e-47 GDP-fucose transporter 1 OS=Drosophila melanogaster GN=nac PE=1 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1442 GDP-fucose transporter Cluster-8309.48190 BP_3 126.41 1.03 6228 642929745 XP_008195958.1 2579 3.6e-288 PREDICTED: uncharacterized protein LOC664426 isoform X1 [Tribolium castaneum]>gi|270010581|gb|EFA07029.1| hypothetical protein TcasGA2_TC010001 [Tribolium castaneum] 242020070 XM_002430435.1 44 9.85009e-11 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05433//PF05887//PF06112//PF09172//PF03067 Glycine zipper 2TM domain//Procyclic acidic repetitive protein (PARP)//Gammaherpesvirus capsid protein//Domain of unknown function (DUF1943)//Chitin binding domain GO:0006869 lipid transport GO:0005319 lipid transporter activity GO:0016020//GO:0019867//GO:0019028 membrane//outer membrane//viral capsid -- -- Cluster-8309.48191 BP_3 84.46 0.66 6492 478259593 ENN79446.1 1339 2.3e-144 hypothetical protein YQE_04090, partial [Dendroctonus ponderosae] 242020070 XM_002430435.1 38 2.22203e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05887//PF05433//PF00957//PF03067 Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain//Synaptobrevin//Chitin binding domain GO:0016192 vesicle-mediated transport -- -- GO:0019028//GO:0016021//GO:0016020//GO:0019867 viral capsid//integral component of membrane//membrane//outer membrane -- -- Cluster-8309.48192 BP_3 1011.41 8.08 6327 642929749 XP_008195960.1 2122 3.6e-235 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] 242020070 XM_002430435.1 38 2.16524e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05433//PF05887//PF03067 Glycine zipper 2TM domain//Procyclic acidic repetitive protein (PARP)//Chitin binding domain -- -- -- -- GO:0019028//GO:0016020//GO:0019867 viral capsid//membrane//outer membrane -- -- Cluster-8309.48193 BP_3 979.82 7.97 6216 642929745 XP_008195958.1 2579 3.6e-288 PREDICTED: uncharacterized protein LOC664426 isoform X1 [Tribolium castaneum]>gi|270010581|gb|EFA07029.1| hypothetical protein TcasGA2_TC010001 [Tribolium castaneum] 242020070 XM_002430435.1 44 9.831e-11 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF09172//PF03067//PF06112//PF05433//PF05887 Domain of unknown function (DUF1943)//Chitin binding domain//Gammaherpesvirus capsid protein//Glycine zipper 2TM domain//Procyclic acidic repetitive protein (PARP) GO:0006869 lipid transport GO:0005319 lipid transporter activity GO:0019867//GO:0016020//GO:0019028 outer membrane//membrane//viral capsid -- -- Cluster-8309.48194 BP_3 7.06 7.77 326 642929747 XP_008195959.1 381 1.4e-34 PREDICTED: uncharacterized protein LOC664426 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15339 Acrosome formation-associated factor GO:0060478//GO:0007342//GO:0006897 acrosomal vesicle exocytosis//fusion of sperm to egg plasma membrane//endocytosis -- -- GO:0005886 plasma membrane -- -- Cluster-8309.48195 BP_3 90.43 0.62 7360 642929749 XP_008195960.1 2131 3.8e-236 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] 242020070 XM_002430435.1 38 2.52083e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05433//PF05887//PF03067//PF09172//PF06112//PF00008 Glycine zipper 2TM domain//Procyclic acidic repetitive protein (PARP)//Chitin binding domain//Domain of unknown function (DUF1943)//Gammaherpesvirus capsid protein//EGF-like domain GO:0006869 lipid transport GO:0005515//GO:0005319 protein binding//lipid transporter activity GO:0016020//GO:0019867//GO:0019028 membrane//outer membrane//viral capsid -- -- Cluster-8309.48196 BP_3 783.33 20.25 2156 642916163 XP_008190912.1 2033 2.5e-225 PREDICTED: abhydrolase domain-containing protein 16A [Tribolium castaneum]>gi|270003703|gb|EFA00151.1| hypothetical protein TcasGA2_TC002972 [Tribolium castaneum] 658893399 XM_008431335.1 63 9.25219e-22 PREDICTED: Poecilia reticulata abhydrolase domain containing 16A (abhd16a), transcript variant X2, mRNA -- -- -- -- Q5R6S0 1171 9.4e-127 Abhydrolase domain-containing protein 16A OS=Pongo abelii GN=ABHD16A PE=2 SV=1 PF00326 Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- KOG1553 Predicted alpha/beta hydrolase BAT5 Cluster-8309.48197 BP_3 235.00 6.34 2077 91078588 XP_972111.1 2168 5.4e-241 PREDICTED: tyrosine-protein kinase-like otk [Tribolium castaneum] -- -- -- -- -- K05127 PTK7, CCK4 PTK7 protein tyrosine kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05127 Q13308 739 1.1e-76 Inactive tyrosine-protein kinase 7 OS=Homo sapiens GN=PTK7 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.48198 BP_3 669.25 9.17 3810 642934333 XP_008198606.1 2979 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X4 [Tribolium castaneum] 817086197 XM_012410395.1 89 5.79494e-36 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 448 1.1e-42 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF00643//PF14634//PF05929//PF00097//PF05524//PF01436//PF05149//PF01637//PF03358//PF02601//PF01580//PF13639 B-box zinc finger//zinc-RING finger domain//Phage capsid scaffolding protein (GPO) serine peptidase//Zinc finger, C3HC4 type (RING finger)//PEP-utilising enzyme, N-terminal//NHL repeat//Paraflagellar rod protein//Archaeal ATPase//NADPH-dependent FMN reductase//Exonuclease VII, large subunit//FtsK/SpoIIIE family//Ring finger domain GO:0009401//GO:0006308//GO:0019069 phosphoenolpyruvate-dependent sugar phosphotransferase system//DNA catabolic process//viral capsid assembly GO:0003677//GO:0005524//GO:0005516//GO:0016491//GO:0005515//GO:0008855//GO:0008270//GO:0000166//GO:0046872 DNA binding//ATP binding//calmodulin binding//oxidoreductase activity//protein binding//exodeoxyribonuclease VII activity//zinc ion binding//nucleotide binding//metal ion binding GO:0031514//GO:0005622//GO:0009318 motile cilium//intracellular//exodeoxyribonuclease VII complex -- -- Cluster-8309.48199 BP_3 754.87 129.79 572 546682799 ERL92688.1 323 1.3e-27 hypothetical protein D910_09999 [Dendroctonus ponderosae] -- -- -- -- -- K13189 RBM14 RNA-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13189 Q96PK6 166 8.6e-11 RNA-binding protein 14 OS=Homo sapiens GN=RBM14 PE=1 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.482 BP_3 14.99 0.38 2183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48200 BP_3 66.44 2.60 1523 642939191 XP_008200374.1 241 1.1e-17 PREDICTED: DNA-binding protein P3A2 isoform X5 [Tribolium castaneum] -- -- -- -- -- K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 154 5.6e-09 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 PF02060 Slow voltage-gated potassium channel GO:0006811//GO:0006813 ion transport//potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0016020//GO:0008076 membrane//voltage-gated potassium channel complex -- -- Cluster-8309.48201 BP_3 190.00 4.39 2378 642939187 XP_008200372.1 1030 5.7e-109 PREDICTED: DNA-binding protein Ewg isoform X3 [Tribolium castaneum] 462310479 APGK01047307.1 62 3.67598e-21 Dendroctonus ponderosae Seq01047317, whole genome shotgun sequence K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 784 7.8e-82 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48203 BP_3 30.07 0.34 4618 91087237 XP_975509.1 1123 1.8e-119 PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|642929695|ref|XP_008195939.1| PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|270010578|gb|EFA07026.1| hypothetical protein TcasGA2_TC009997 [Tribolium castaneum] 827564585 CP011663.1 41 3.39121e-09 Clostridium sporogenes strain DSM 795, complete genome K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 961 4.5e-102 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF03244//PF00490//PF16834 Photosystem I reaction centre subunit VI//Delta-aminolevulinic acid dehydratase//Shu complex component Csm2, DNA-binding GO:0000725//GO:0015979//GO:0033014//GO:0015994 recombinational repair//photosynthesis//tetrapyrrole biosynthetic process//chlorophyll metabolic process GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding GO:0009538//GO:0097196//GO:0005634//GO:0009522 photosystem I reaction center//Shu complex//nucleus//photosystem I KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.48204 BP_3 228.79 4.34 2835 91087237 XP_975509.1 1259 1.9e-135 PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|642929695|ref|XP_008195939.1| PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|270010578|gb|EFA07026.1| hypothetical protein TcasGA2_TC009997 [Tribolium castaneum] 827564585 CP011663.1 41 2.07159e-09 Clostridium sporogenes strain DSM 795, complete genome K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 1035 7.3e-111 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF03244//PF00490 Photosystem I reaction centre subunit VI//Delta-aminolevulinic acid dehydratase GO:0033014//GO:0015994//GO:0015979 tetrapyrrole biosynthetic process//chlorophyll metabolic process//photosynthesis GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding GO:0009522//GO:0009538 photosystem I//photosystem I reaction center KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.48205 BP_3 13.68 0.37 2055 91088681 XP_974930.1 727 6.7e-74 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99536 343 9.3e-31 Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens GN=VAT1 PE=1 SV=2 PF08240//PF00107 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.48206 BP_3 505.01 5.23 4943 642939444 XP_008200394.1 1205 6.0e-129 PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939446|ref|XP_008200396.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939448|ref|XP_008200397.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939450|ref|XP_008200398.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum] 642939445 XM_008202174.1 38 1.68969e-07 PREDICTED: Tribolium castaneum transcription factor E2F2-like (LOC656396), transcript variant X2, mRNA K06620 E2F3 transcription factor E2F3 http://www.genome.jp/dbget-bin/www_bget?ko:K06620 O00716 437 2.8e-41 Transcription factor E2F3 OS=Homo sapiens GN=E2F3 PE=1 SV=1 PF02319//PF01991 E2F/DP family winged-helix DNA-binding domain//ATP synthase (E/31 kDa) subunit GO:0006355//GO:0015992//GO:0006119//GO:0015991 regulation of transcription, DNA-templated//proton transport//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0003700//GO:0046961 transcription factor activity, sequence-specific DNA binding//proton-transporting ATPase activity, rotational mechanism GO:0005667//GO:0033178 transcription factor complex//proton-transporting two-sector ATPase complex, catalytic domain KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.48207 BP_3 508.02 5.32 4896 91080109 XP_967250.1 2065 1.1e-228 PREDICTED: uncharacterized protein LOC655596 isoform X1 [Tribolium castaneum]>gi|270003190|gb|EEZ99637.1| hypothetical protein TcasGA2_TC002393 [Tribolium castaneum] -- -- -- -- -- K15559 RTT103 regulator of Ty1 transposition protein 103 http://www.genome.jp/dbget-bin/www_bget?ko:K15559 Q9CSU0 773 3.0e-80 Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Mus musculus GN=Rprd1b PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.48208 BP_3 366.80 11.03 1895 642917679 XP_008191324.1 527 9.6e-51 PREDICTED: poly(A) polymerase type 3 [Tribolium castaneum]>gi|642917681|ref|XP_008191326.1| PREDICTED: poly(A) polymerase type 3 [Tribolium castaneum] 642917680 XM_008193104.1 52 1.05702e-15 PREDICTED: Tribolium castaneum poly(A) polymerase type 3 (LOC103312455), transcript variant X2, mRNA K14376 PAP poly(A) polymerase http://www.genome.jp/dbget-bin/www_bget?ko:K14376 Q6PCL9 371 4.8e-34 Poly(A) polymerase gamma OS=Mus musculus GN=Papolg PE=1 SV=1 PF04928//PF04926 Poly(A) polymerase central domain//Poly(A) polymerase predicted RNA binding domain GO:0043631 RNA polyadenylation GO:0004652//GO:0003723 polynucleotide adenylyltransferase activity//RNA binding -- -- KOG2245 Poly(A) polymerase and related nucleotidyltransferases Cluster-8309.48209 BP_3 24.35 0.46 2834 524873532 XP_005093511.1 211 6.3e-14 PREDICTED: low-density lipoprotein receptor-related protein 4-like [Aplysia californica] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 Q9JI18 177 2.3e-11 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057//PF14659 Low-density lipoprotein receptor domain class A//Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.48215 BP_3 318.21 15.40 1288 91092722 XP_972691.1 1473 1.3e-160 PREDICTED: arrestin domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270014876|gb|EFA11324.1| hypothetical protein TcasGA2_TC010863 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TBH0 266 4.9e-22 Arrestin domain-containing protein 2 OS=Homo sapiens GN=ARRDC2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.48216 BP_3 599.21 6.55 4699 642925990 XP_008194721.1 3152 0.0e+00 PREDICTED: DNA repair and recombination protein RAD54-like [Tribolium castaneum] -- -- -- -- -- K10875 RAD54L, RAD54 DNA repair and recombination protein RAD54 and RAD54-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K10875 Q92698 2269 9.8e-254 DNA repair and recombination protein RAD54-like OS=Homo sapiens GN=RAD54L PE=1 SV=2 PF04851//PF01484//PF00176//PF08658 Type III restriction enzyme, res subunit//Nematode cuticle collagen N-terminal domain//SNF2 family N-terminal domain//Rad54 N terminal -- -- GO:0016817//GO:0042302//GO:0005524//GO:0016787//GO:0003677 hydrolase activity, acting on acid anhydrides//structural constituent of cuticle//ATP binding//hydrolase activity//DNA binding -- -- KOG0390 DNA repair protein, SNF2 family Cluster-8309.48218 BP_3 77.22 2.29 1916 820805520 AKG92751.1 846 9.9e-88 steroid receptor coactivator [Leptinotarsa decemlineata] 820805519 KP147914.1 185 1.24356e-89 Leptinotarsa decemlineata steroid receptor coactivator mRNA, complete cds K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48220 BP_3 92.46 1.63 3030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11968//PF01853 Putative methyltransferase (DUF3321)//MOZ/SAS family GO:0006396//GO:0000154//GO:0006355 RNA processing//rRNA modification//regulation of transcription, DNA-templated GO:0016747//GO:0016433 transferase activity, transferring acyl groups other than amino-acyl groups//rRNA (adenine) methyltransferase activity -- -- -- -- Cluster-8309.48221 BP_3 848.07 14.59 3094 270003145 EEZ99592.1 4008 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.3e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF04579//PF00069//PF07714 Keratin, high-sulphur matrix protein//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005198 ATP binding//protein kinase activity//structural molecule activity GO:0045095 keratin filament KOG1094 Discoidin domain receptor DDR1 Cluster-8309.48224 BP_3 15.54 0.75 1290 642929723 XP_008195952.1 1432 7.5e-156 PREDICTED: spastin [Tribolium castaneum]>gi|270010589|gb|EFA07037.1| hypothetical protein TcasGA2_TC010011 [Tribolium castaneum] -- -- -- -- -- K13254 SPAST spastin http://www.genome.jp/dbget-bin/www_bget?ko:K13254 B3M301 991 4.2e-106 Spastin OS=Drosophila ananassae GN=spas PE=3 SV=1 PF13414//PF00910//PF00515//PF00004//PF01695//PF07728//PF05496//PF06068 TPR repeat//RNA helicase//Tetratricopeptide repeat//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0016887//GO:0009378//GO:0003724//GO:0005524//GO:0003678//GO:0003723//GO:0008568//GO:0005515 ATPase activity//four-way junction helicase activity//RNA helicase activity//ATP binding//DNA helicase activity//RNA binding//microtubule-severing ATPase activity//protein binding GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG0740 AAA+-type ATPase Cluster-8309.48226 BP_3 54.02 1.54 1977 546675591 ERL86754.1 2118 3.3e-235 hypothetical protein D910_04160 [Dendroctonus ponderosae] 752860506 XM_011253949.1 341 2.44684e-176 PREDICTED: Camponotus floridanus serine/threonine-protein kinase tricorner (LOC105248897), transcript variant X1, mRNA K08790 STK38, NDR serine/threonine kinase 38 http://www.genome.jp/dbget-bin/www_bget?ko:K08790 Q2LZZ7 1949 5.3e-217 Serine/threonine-protein kinase tricorner OS=Drosophila pseudoobscura pseudoobscura GN=trc PE=3 SV=1 PF00069//PF06293//PF00433//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0016773//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0605 NDR and related serine/threonine kinases Cluster-8309.48227 BP_3 51.64 1.12 2521 642929027 XP_973541.3 829 1.2e-85 PREDICTED: probable maleylacetoacetate isomerase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01800 maiA, GSTZ1 maleylacetoacetate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01800 Q9VHD2 786 4.9e-82 Probable maleylacetoacetate isomerase 2 OS=Drosophila melanogaster GN=GstZ2 PE=1 SV=1 PF13409//PF02798//PF13417//PF00462 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG0868 Glutathione S-transferase Cluster-8309.48230 BP_3 5.25 0.69 660 642937453 XP_008198842.1 316 9.8e-27 PREDICTED: protein tramtrack, beta isoform-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48231 BP_3 207.11 2.21 4810 91087363 XP_975631.1 632 1.6e-62 PREDICTED: iron-sulfur cluster assembly enzyme ISCU, mitochondrial [Tribolium castaneum]>gi|270010618|gb|EFA07066.1| hypothetical protein TcasGA2_TC010045 [Tribolium castaneum] 844835377 XM_012936598.1 119 1.54249e-52 Schistosoma haematobium Iron-sulfur cluster assembly enzyme ISCU, mitochondrial mRNA K04488 iscU, nifU nitrogen fixation protein NifU and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K04488 Q9D7P6 568 1.8e-56 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial OS=Mus musculus GN=Iscu PE=1 SV=1 PF05735//PF01592//PF09494 Thrombospondin C-terminal region//NifU-like N terminal domain//Slx4 endonuclease GO:0016226//GO:0006281//GO:0007155//GO:0006260//GO:0006308 iron-sulfur cluster assembly//DNA repair//cell adhesion//DNA replication//DNA catabolic process GO:0017108//GO:0005509//GO:0051536//GO:0005506 5'-flap endonuclease activity//calcium ion binding//iron-sulfur cluster binding//iron ion binding GO:0005634//GO:0005576//GO:0033557 nucleus//extracellular region//Slx1-Slx4 complex KOG3361 Iron binding protein involved in Fe-S cluster formation Cluster-8309.48232 BP_3 76.57 0.49 7759 642923618 XP_008193579.1 8928 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: dedicator of cytokinesis protein 9 [Tribolium castaneum] 815808572 XM_012369703.1 116 1.16044e-50 PREDICTED: Linepithema humile dedicator of cytokinesis protein 9 (LOC105673797), transcript variant X4, mRNA -- -- -- -- Q9BZ29 2338 1.6e-261 Dedicator of cytokinesis protein 9 OS=Homo sapiens GN=DOCK9 PE=1 SV=2 PF03810//PF02936//PF02183 Importin-beta N-terminal domain//Cytochrome c oxidase subunit IV//Homeobox associated leucine zipper GO:0006123//GO:0006886//GO:0006355//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//regulation of transcription, DNA-templated//proton transport GO:0008536//GO:0043565//GO:0003700//GO:0004129 Ran GTPase binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//cytochrome-c oxidase activity GO:0005667//GO:0045277 transcription factor complex//respiratory chain complex IV KOG1997 PH domain-containing protein Cluster-8309.48233 BP_3 826.64 20.89 2199 189236353 XP_001807129.1 2395 2.7e-267 PREDICTED: signal recognition particle receptor subunit alpha homolog [Tribolium castaneum]>gi|270005877|gb|EFA02325.1| hypothetical protein TcasGA2_TC007993 [Tribolium castaneum] 720030593 XM_010267260.1 42 4.45448e-10 PREDICTED: Nelumbo nucifera signal recognition particle receptor subunit alpha-like (LOC104603264), transcript variant X4, mRNA K13431 SRPR signal recognition particle receptor subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13431 Q9U5L1 1446 1.2e-158 Signal recognition particle receptor subunit alpha homolog OS=Drosophila melanogaster GN=Gtp-bp PE=1 SV=2 PF03266//PF01926//PF02881//PF04086//PF00448 NTPase//50S ribosome-binding GTPase//SRP54-type protein, helical bundle domain//Signal recognition particle, alpha subunit, N-terminal//SRP54-type protein, GTPase domain GO:0006614//GO:0006886//GO:0006184 SRP-dependent cotranslational protein targeting to membrane//intracellular protein transport//obsolete GTP catabolic process GO:0098519//GO:0003924//GO:0005525//GO:0005047 nucleotide phosphatase activity, acting on free nucleotides//GTPase activity//GTP binding//signal recognition particle binding GO:0005786//GO:0005785 signal recognition particle, endoplasmic reticulum targeting//signal recognition particle receptor complex KOG0781 Signal recognition particle receptor, alpha subunit Cluster-8309.48234 BP_3 458.20 7.18 3369 91082299 XP_974015.1 1414 2.4e-153 PREDICTED: cell differentiation protein RCD1 homolog [Tribolium castaneum]>gi|270007201|gb|EFA03649.1| hypothetical protein TcasGA2_TC013743 [Tribolium castaneum] -- -- -- -- -- K12606 RCD1, CNOT9, CAF40 CCR4-NOT transcription complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12606 A7MB47 1248 1.7e-135 Cell differentiation protein RCD1 homolog OS=Bos taurus GN=RQCD1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3036 Protein involved in cell differentiation/sexual development Cluster-8309.48235 BP_3 72.00 3.59 1259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48236 BP_3 314.30 5.79 2910 642922915 XP_008200450.1 3722 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X1 [Tribolium castaneum]>gi|270006550|gb|EFA02998.1| hypothetical protein TcasGA2_TC010420 [Tribolium castaneum] 642922916 XM_008202229.1 361 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5F499 2244 4.8e-251 Dynamin-like 120 kDa protein, mitochondrial OS=Gallus gallus GN=OPA1 PE=2 SV=1 PF00071//PF02421//PF01926//PF13304//PF01031//PF08477 Ras family//Ferrous iron transport protein B//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Dynamin central region//Ras of Complex, Roc, domain of DAPkinase GO:0006184//GO:0007264//GO:0015684 obsolete GTP catabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0005524//GO:0015093//GO:0003924 GTP binding//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.48237 BP_3 42.76 1.11 2152 91079304 XP_966317.1 1435 5.6e-156 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 648 4.2e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.48238 BP_3 18.84 0.33 3038 91081979 XP_968359.1 2904 0.0e+00 PREDICTED: ubiquitin-protein ligase E3C [Tribolium castaneum]>gi|270007369|gb|EFA03817.1| hypothetical protein TcasGA2_TC013932 [Tribolium castaneum] -- -- -- -- -- K10589 UBE3C ubiquitin-protein ligase E3 C http://www.genome.jp/dbget-bin/www_bget?ko:K10589 Q15386 1282 1.8e-139 Ubiquitin-protein ligase E3C OS=Homo sapiens GN=UBE3C PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.48239 BP_3 1.00 3.30 277 -- -- -- -- -- 768311758 CP010986.1 98 3.72369e-42 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48240 BP_3 85.21 0.72 6033 332376639 AEE63459.1 1639 3.5e-179 unknown [Dendroctonus ponderosae] 808145633 XM_012318648.1 265 1.33758e-133 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K15174 PAF1 RNA polymerase II-associated factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15174 B3A0N5 1282 3.6e-139 Apyrase OS=Tabanus yao PE=1 SV=1 PF01757//PF02872//PF00149//PF03985 Acyltransferase family//5'-nucleotidase, C-terminal domain//Calcineurin-like phosphoesterase//Paf1 GO:0006368//GO:0009166//GO:0016570 transcription elongation from RNA polymerase II promoter//nucleotide catabolic process//histone modification GO:0016747//GO:0016787 transferase activity, transferring acyl groups other than amino-acyl groups//hydrolase activity GO:0016593 Cdc73/Paf1 complex KOG2478 Putative RNA polymerase II regulator Cluster-8309.48241 BP_3 28.35 0.34 4305 270008878 EFA05326.1 1127 5.8e-120 hypothetical protein TcasGA2_TC015490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 347 6.7e-31 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF15957//PF03067//PF04277//PF00089 Commissureless//Chitin binding domain//Oxaloacetate decarboxylase, gamma chain//Trypsin GO:0006560//GO:0006525//GO:0007411//GO:0006814//GO:0006090//GO:0071436//GO:0006508 proline metabolic process//arginine metabolic process//axon guidance//sodium ion transport//pyruvate metabolic process//sodium ion export//proteolysis GO:0008948//GO:0015081//GO:0004252 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity//serine-type endopeptidase activity GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-8309.48243 BP_3 114.94 1.41 4230 642938247 XP_008198128.1 296 1.3e-23 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 58 1.10073e-18 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF17096//PF02932//PF01080//PF03293 Altered inheritance of mitochondria protein 3//Neurotransmitter-gated ion-channel transmembrane region//Presenilin//Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006144//GO:0006351//GO:0019083//GO:0006811//GO:0051016//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//viral transcription//ion transport//barbed-end actin filament capping//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0004190 DNA-directed RNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0016021//GO:0030479//GO:0005730//GO:0016020 integral component of membrane//actin cortical patch//nucleolus//membrane -- -- Cluster-8309.48246 BP_3 297.25 17.68 1102 91088815 XP_976275.1 426 2.9e-39 PREDICTED: uncharacterized protein LOC658222 [Tribolium castaneum]>gi|270011614|gb|EFA08062.1| hypothetical protein TcasGA2_TC005658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48247 BP_3 179.75 3.96 2481 478250027 ENN70533.1 303 1.2e-24 hypothetical protein YQE_12709, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48248 BP_3 42.23 4.62 732 91088815 XP_976275.1 492 4.2e-47 PREDICTED: uncharacterized protein LOC658222 [Tribolium castaneum]>gi|270011614|gb|EFA08062.1| hypothetical protein TcasGA2_TC005658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48249 BP_3 228.94 13.20 1128 91088815 XP_976275.1 492 6.5e-47 PREDICTED: uncharacterized protein LOC658222 [Tribolium castaneum]>gi|270011614|gb|EFA08062.1| hypothetical protein TcasGA2_TC005658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48251 BP_3 69.17 1.54 2460 270009092 EFA05540.1 3462 0.0e+00 hypothetical protein TcasGA2_TC015727 [Tribolium castaneum] 642926476 XM_008193752.1 368 0 PREDICTED: Tribolium castaneum protein suppressor of forked (LOC661644), mRNA K14408 CSTF3, RNA14 cleavage stimulation factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14408 P25991 2395 1.3e-268 Protein suppressor of forked OS=Drosophila melanogaster GN=su(f) PE=1 SV=2 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG1914 mRNA cleavage and polyadenylation factor I complex, subunit RNA14 Cluster-8309.48254 BP_3 76.68 1.14 3527 646721974 KDR23118.1 1876 6.7e-207 HEAT repeat-containing protein 6 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q5R5R2 1224 1.1e-132 HEAT repeat-containing protein 6 OS=Pongo abelii GN=HEATR6 PE=2 SV=1 PF02985//PF01106//PF00514//PF01667 HEAT repeat//NifU-like domain//Armadillo/beta-catenin-like repeat//Ribosomal protein S27 GO:0042254//GO:0006412//GO:0016226 ribosome biogenesis//translation//iron-sulfur cluster assembly GO:0005506//GO:0003735//GO:0051536//GO:0005515 iron ion binding//structural constituent of ribosome//iron-sulfur cluster binding//protein binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.48257 BP_3 715.21 3.14 11257 642936312 XP_008198391.1 8183 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 9.72605e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3630 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF14604//PF00018//PF01608//PF07651//PF03822 Variant SH3 domain//SH3 domain//I/LWEQ domain//ANTH domain//NAF domain GO:0007165 signal transduction GO:0005543//GO:0003779//GO:0005515 phospholipid binding//actin binding//protein binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.48258 BP_3 24.16 0.41 3148 642917631 XP_008193400.1 1842 5.2e-203 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 968 4.8e-103 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF01585//PF01728//PF00846 G-patch domain//FtsJ-like methyltransferase//Hantavirus nucleocapsid protein GO:0032259 methylation GO:0008168//GO:0003676 methyltransferase activity//nucleic acid binding GO:0019013 viral nucleocapsid KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.48259 BP_3 28.91 0.51 3004 642917631 XP_008193400.1 1842 5.0e-203 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 968 4.6e-103 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF00846//PF01728//PF01585 Hantavirus nucleocapsid protein//FtsJ-like methyltransferase//G-patch domain GO:0032259 methylation GO:0003676//GO:0008168 nucleic acid binding//methyltransferase activity GO:0019013 viral nucleocapsid KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.48260 BP_3 238.70 7.49 1828 642917631 XP_008193400.1 1859 3.2e-205 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 967 3.6e-103 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.48267 BP_3 45.04 0.83 2910 642913836 XP_001815393.2 1504 7.5e-164 PREDICTED: engulfment and cell motility protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92556 408 3.8e-38 Engulfment and cell motility protein 1 OS=Homo sapiens GN=ELMO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48268 BP_3 1251.32 13.52 4752 270014286 EFA10734.1 1118 7.1e-119 transformer2, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O18391 492 1.1e-47 Probable serine hydrolase OS=Drosophila melanogaster GN=kraken PE=2 SV=1 PF07819//PF02205 PGAP1-like protein//WH2 motif GO:0006886//GO:0006505 intracellular protein transport//GPI anchor metabolic process GO:0003779//GO:0016788 actin binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.48273 BP_3 156.25 3.82 2265 189241329 XP_001808868.1 187 3.0e-11 PREDICTED: uncharacterized protein LOC100142578 [Tribolium castaneum]>gi|270014077|gb|EFA10525.1| hypothetical protein TcasGA2_TC012777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane -- -- Cluster-8309.48275 BP_3 19.00 1.77 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48277 BP_3 443.44 2.60 8525 189234241 XP_976116.2 354 5.0e-30 PREDICTED: high affinity copper uptake protein 1 isoform X2 [Tribolium castaneum] 194896366 XM_001978429.1 74 2.84034e-27 Drosophila erecta GG19602 (Dere\GG19602), mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 262 9.5e-21 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF06305//PF04145//PF02033 Protein of unknown function (DUF1049)//Ctr copper transporter family//Ribosome-binding factor A GO:0006825//GO:0035434//GO:0006364 copper ion transport//copper ion transmembrane transport//rRNA processing GO:0005375 copper ion transmembrane transporter activity GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane KOG3386 Copper transporter Cluster-8309.48278 BP_3 81.00 2.52 1838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48279 BP_3 93.53 0.55 8519 478261817 ENN80940.1 1262 2.5e-135 hypothetical protein YQE_02645, partial [Dendroctonus ponderosae]>gi|546673708|gb|ERL85267.1| hypothetical protein D910_02688 [Dendroctonus ponderosae] -- -- -- -- -- K05610 UCHL5, UCH37 ubiquitin carboxyl-terminal hydrolase L5 http://www.genome.jp/dbget-bin/www_bget?ko:K05610 Q9XSJ0 1055 1.1e-112 Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Bos taurus GN=UCHL5 PE=2 SV=1 PF00397//PF01404//PF00552//PF02845//PF01088//PF00325 WW domain//Ephrin receptor ligand binding domain//Integrase DNA binding domain//CUE domain//Ubiquitin carboxyl-terminal hydrolase, family 1//Bacterial regulatory proteins, crp family GO:0016579//GO:0006355//GO:0006511//GO:0006508//GO:0048013 protein deubiquitination//regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process//proteolysis//ephrin receptor signaling pathway GO:0005515//GO:0004843//GO:0003677//GO:0003676 protein binding//ubiquitin-specific protease activity//DNA binding//nucleic acid binding GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.48280 BP_3 532.27 6.88 4022 642927313 XP_974796.3 1396 3.5e-151 PREDICTED: uncharacterized protein LOC663667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.9e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF08043//PF03359//PF01544//PF02653 Xin repeat//Guanylate-kinase-associated protein (GKAP) protein//CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component GO:0006810//GO:0055085//GO:0030001//GO:0030036//GO:0023052 transport//transmembrane transport//metal ion transport//actin cytoskeleton organization//signaling GO:0003779//GO:0005215//GO:0046873 actin binding//transporter activity//metal ion transmembrane transporter activity GO:0016020//GO:0030054 membrane//cell junction KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.48281 BP_3 53.59 0.47 5801 642914389 XP_008201657.1 2571 2.8e-287 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K08836 SLK STE20-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08836 Q9H2G2 693 6.8e-71 STE20-like serine/threonine-protein kinase OS=Homo sapiens GN=SLK PE=1 SV=1 PF12474//PF06293//PF00069//PF07714 Polo kinase kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004674//GO:0004672//GO:0016773 ATP binding//protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.48283 BP_3 498.80 4.43 5723 642931136 XP_967600.2 3863 0.0e+00 PREDICTED: DNA-directed RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270012086|gb|EFA08534.1| hypothetical protein TcasGA2_TC006188 [Tribolium castaneum] -- -- -- -- -- K10908 POLRMT, RPO41 DNA-directed RNA polymerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K10908 Q8BKF1 1977 8.7e-220 DNA-directed RNA polymerase, mitochondrial OS=Mus musculus GN=Polrmt PE=2 SV=1 PF00940//PF03840 DNA-dependent RNA polymerase//Preprotein translocase SecG subunit GO:0009306//GO:0006144//GO:0006351//GO:0015031//GO:0006206 protein secretion//purine nucleobase metabolic process//transcription, DNA-templated//protein transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0016740//GO:0003677//GO:0015450 DNA-directed RNA polymerase activity//transferase activity//DNA binding//P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0016021//GO:0009941//GO:0005730 integral component of membrane//chloroplast envelope//nucleolus KOG1038 Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation Cluster-8309.48284 BP_3 155.51 1.59 5007 91084547 XP_973113.1 3577 0.0e+00 PREDICTED: protein unc-45 homolog B [Tribolium castaneum]>gi|270009248|gb|EFA05696.1| translocase of outer membrane 34 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F64 1674 1.0e-184 Protein unc-45 homolog B OS=Xenopus laevis GN=unc45b PE=2 SV=1 PF00839//PF00514//PF13181//PF13176//PF03152//PF08718//PF13414//PF13371//PF13374//PF00515 Cysteine rich repeat//Armadillo/beta-catenin-like repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Ubiquitin fusion degradation protein UFD1//Glycolipid transfer protein (GLTP)//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0046836//GO:0006511 glycolipid transport//ubiquitin-dependent protein catabolic process GO:0005515//GO:0017089//GO:0051861 protein binding//glycolipid transporter activity//glycolipid binding GO:0005737//GO:0016020 cytoplasm//membrane KOG1816 Ubiquitin fusion-degradation protein Cluster-8309.48287 BP_3 287.87 2.18 6658 270006862 EFA03310.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013252 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q96IG2 1483 1.9e-162 F-box/LRR-repeat protein 20 OS=Homo sapiens GN=FBXL20 PE=1 SV=2 PF15966//PF00646//PF00560//PF02126//PF12937//PF13516//PF00152//PF13855 F-box//F-box domain//Leucine Rich Repeat//Phosphotriesterase family//F-box-like//Leucine Rich repeat//tRNA synthetases class II (D, K and N)//Leucine rich repeat GO:0009056//GO:0006418 catabolic process//tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0008270//GO:0005515//GO:0004812 ATP binding//nucleotide binding//zinc ion binding//protein binding//aminoacyl-tRNA ligase activity -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.48289 BP_3 1760.22 27.63 3362 642922441 XP_008193170.1 2357 1.1e-262 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 642922838 XM_968977.2 327 2.53921e-168 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X2, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1929 1.9e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF02781//PF00180//PF00479 Glucose-6-phosphate dehydrogenase, C-terminal domain//Isocitrate/isopropylmalate dehydrogenase//Glucose-6-phosphate dehydrogenase, NAD binding domain GO:0055114//GO:0006098//GO:0006006//GO:0006749 oxidation-reduction process//pentose-phosphate shunt//glucose metabolic process//glutathione metabolic process GO:0016616//GO:0004345//GO:0050661 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glucose-6-phosphate dehydrogenase activity//NADP binding -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.4829 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48290 BP_3 2.00 0.47 498 270010730 EFA07178.1 196 6.0e-13 hypothetical protein TcasGA2_TC010178 [Tribolium castaneum] -- -- -- -- -- K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 O02194 183 8.0e-13 Presenilin homolog OS=Drosophila melanogaster GN=Psn PE=1 SV=2 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2736 Presenilin Cluster-8309.48294 BP_3 619.42 8.43 3832 642912272 XP_008200632.1 786 1.8e-80 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 9.5e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF01414//PF00089 Delta serrate ligand//Trypsin GO:0006508//GO:0007154 proteolysis//cell communication GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.48299 BP_3 64.59 5.09 903 642926336 XP_008194882.1 653 1.1e-65 PREDICTED: LOW QUALITY PROTEIN: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [Tribolium castaneum] 642926335 XM_008196660.1 192 7.38168e-94 PREDICTED: Tribolium castaneum retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (LOC657343), mRNA K13758 PDE6D retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K13758 Q9XT54 580 1.3e-58 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Canis familiaris GN=PDE6D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4038 cGMP-phosphodiesterase, delta subunit Cluster-8309.483 BP_3 68.47 5.10 939 769864913 XP_011644363.1 276 6.0e-22 PREDICTED: GSK3-beta interaction protein [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- Q7ZWI4 197 3.6e-14 GSK3-beta interaction protein OS=Danio rerio GN=gskip PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3965 Uncharacterized conserved protein Cluster-8309.48300 BP_3 11.41 0.49 1409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48302 BP_3 19.00 4.68 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01093 Clusterin GO:0008219 cell death -- -- -- -- -- -- Cluster-8309.48303 BP_3 295.56 4.85 3226 546682308 ERL92261.1 525 2.8e-50 hypothetical protein D910_09578, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y530 373 4.8e-34 O-acetyl-ADP-ribose deacetylase 1 OS=Homo sapiens GN=OARD1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48304 BP_3 14.78 1.05 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48307 BP_3 1.00 0.38 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48308 BP_3 221.27 1.30 8473 642918927 XP_008191660.1 739 1.1e-74 PREDICTED: uncharacterized protein LOC662701 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34258 210 1.0e-14 Uncharacterized protein B0303.7 OS=Caenorhabditis elegans GN=B0303.7 PE=1 SV=5 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4225 Sorbin and SH3 domain-containing protein Cluster-8309.48309 BP_3 17.00 0.46 2054 478252125 ENN72556.1 745 5.5e-76 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 351 1.1e-31 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF03144//PF00107 Elongation factor Tu domain 2//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0005525 GTP binding -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48310 BP_3 32.00 4.70 620 3287775 P81387.1 400 1.7e-36 RecName: Full=Cuticle protein AMP3; AltName: Full=HA-AMP3 [Homarus americanus] -- -- -- -- -- -- -- -- -- P81576 446 3.2e-43 Cuticle protein AM1159 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.48311 BP_3 26.05 0.50 2812 91091470 XP_973218.1 335 2.6e-28 PREDICTED: peroxisomal membrane protein 11C [Tribolium castaneum]>gi|270000949|gb|EEZ97396.1| hypothetical protein TcasGA2_TC011223 [Tribolium castaneum] -- -- -- -- -- K13353 PEX11C peroxin-11C http://www.genome.jp/dbget-bin/www_bget?ko:K13353 Q96HA9 139 5.7e-07 Peroxisomal membrane protein 11C OS=Homo sapiens GN=PEX11G PE=1 SV=1 PF05648 Peroxisomal biogenesis factor 11 (PEX11) GO:0016559 peroxisome fission -- -- GO:0005779 integral component of peroxisomal membrane -- -- Cluster-8309.48313 BP_3 421.03 11.03 2131 642910461 XP_008190748.1 2013 5.3e-223 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] 462340826 APGK01036266.1 75 1.95134e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1199 5.3e-130 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF02313//PF00069//PF07714//PF06305 Fumarate reductase subunit D//Protein kinase domain//Protein tyrosine kinase//Protein of unknown function (DUF1049) GO:0006468//GO:0006106 protein phosphorylation//fumarate metabolic process GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.48314 BP_3 289.92 1.73 8358 91078526 XP_970233.1 5708 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.68771e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3738 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF10233//PF01059//PF16692//PF09606//PF00400//PF00472 Uncharacterized conserved protein CG6151-P//NADH-ubiquinone oxidoreductase chain 4, amino terminus//Folliculin C-terminal domain//ARC105 or Med15 subunit of Mediator complex non-fungal//WD domain, G-beta repeat//RF-1 domain GO:0006120//GO:0006449//GO:0055114//GO:0043087//GO:0006415//GO:0006357 mitochondrial electron transport, NADH to ubiquinone//regulation of translational termination//oxidation-reduction process//regulation of GTPase activity//translational termination//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0003747//GO:0001104//GO:0005085 protein binding//translation release factor activity//RNA polymerase II transcription cofactor activity//guanyl-nucleotide exchange factor activity GO:0016021//GO:0016592//GO:0018444//GO:0005840 integral component of membrane//mediator complex//translation release factor complex//ribosome KOG3154 Uncharacterized conserved protein Cluster-8309.48315 BP_3 59.05 0.35 8387 91078526 XP_970233.1 4667 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.69359e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3270 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF00472//PF00400//PF09606//PF16692//PF01059//PF10233 RF-1 domain//WD domain, G-beta repeat//ARC105 or Med15 subunit of Mediator complex non-fungal//Folliculin C-terminal domain//NADH-ubiquinone oxidoreductase chain 4, amino terminus//Uncharacterized conserved protein CG6151-P GO:0055114//GO:0006415//GO:0043087//GO:0006357//GO:0006120//GO:0006449 oxidation-reduction process//translational termination//regulation of GTPase activity//regulation of transcription from RNA polymerase II promoter//mitochondrial electron transport, NADH to ubiquinone//regulation of translational termination GO:0005515//GO:0001104//GO:0003747//GO:0005085 protein binding//RNA polymerase II transcription cofactor activity//translation release factor activity//guanyl-nucleotide exchange factor activity GO:0018444//GO:0005840//GO:0016021//GO:0016592 translation release factor complex//ribosome//integral component of membrane//mediator complex KOG3154 Uncharacterized conserved protein Cluster-8309.48318 BP_3 617.04 3.72 8296 91078526 XP_970233.1 5708 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.67513e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3738 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF01059//PF00400//PF00472//PF16692 NADH-ubiquinone oxidoreductase chain 4, amino terminus//WD domain, G-beta repeat//RF-1 domain//Folliculin C-terminal domain GO:0055114//GO:0043087//GO:0006415//GO:0006120//GO:0006449 oxidation-reduction process//regulation of GTPase activity//translational termination//mitochondrial electron transport, NADH to ubiquinone//regulation of translational termination GO:0005515//GO:0003747//GO:0005085 protein binding//translation release factor activity//guanyl-nucleotide exchange factor activity GO:0018444//GO:0005840 translation release factor complex//ribosome KOG3154 Uncharacterized conserved protein Cluster-8309.48323 BP_3 227.06 1.48 7675 642917299 XP_008199241.1 7102 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X2 [Tribolium castaneum] 665815961 XM_008558446.1 862 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 5103 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF01297//PF00501//PF06464 Zinc-uptake complex component A periplasmic//AMP-binding enzyme//DMAP1-binding Domain GO:0030001//GO:0008152 metal ion transport//metabolic process GO:0008134//GO:0046872//GO:0003824 transcription factor binding//metal ion binding//catalytic activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3628 Predicted AMP-binding protein Cluster-8309.48326 BP_3 48.91 0.76 3390 91081173 XP_975583.1 1068 3.2e-113 PREDICTED: mitochondrial 2-oxodicarboxylate carrier [Tribolium castaneum]>gi|270006043|gb|EFA02491.1| hypothetical protein TcasGA2_TC008186 [Tribolium castaneum] -- -- -- -- -- K15110 SLC25A21, ODC solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15110 Q9BQT8 761 5.2e-79 Mitochondrial 2-oxodicarboxylate carrier OS=Homo sapiens GN=SLC25A21 PE=1 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0754 Mitochondrial oxodicarboxylate carrier protein Cluster-8309.48329 BP_3 38.18 0.35 5492 642933323 XP_008197368.1 1129 4.3e-120 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 641 6.9e-65 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.4833 BP_3 2.00 0.36 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48330 BP_3 80.97 0.32 12307 642930533 XP_008196445.1 3903 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12 [Tribolium castaneum] 795050965 XM_012014653.1 477 0 PREDICTED: Vollenhovia emeryi inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC105563237), transcript variant X7, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 3245 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.48334 BP_3 637.00 12.47 2754 642924477 XP_008194313.1 1368 4.2e-148 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270007914|gb|EFA04362.1| hypothetical protein TcasGA2_TC014658 [Tribolium castaneum] 642924476 XM_008196091.1 186 4.99452e-90 PREDICTED: Tribolium castaneum insulin-like growth factor-binding protein complex acid labile subunit (LOC660991), mRNA -- -- -- -- O94898 299 1.6e-25 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens GN=LRIG2 PE=2 SV=3 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48337 BP_3 61.96 1.63 2128 91092598 XP_970550.1 686 3.9e-69 PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|642921812|ref|XP_008199330.1| PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|270006629|gb|EFA03077.1| hypothetical protein TcasGA2_TC010951 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q8NEJ0 361 7.8e-33 Dual specificity protein phosphatase 18 OS=Homo sapiens GN=DUSP18 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0016311//GO:0006570//GO:0006470 dephosphorylation//tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0016791//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1718 Dual specificity phosphatase Cluster-8309.48340 BP_3 105.70 3.57 1717 642936844 XP_008197869.1 1620 1.6e-177 PREDICTED: E3 ubiquitin-protein ligase listerin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VW09 741 5.5e-77 E3 ubiquitin-protein ligase listerin OS=Drosophila melanogaster GN=l(3)76BDr PE=1 SV=2 PF12861//PF13639//PF00097//PF16866//PF12678//PF12906//PF00628//PF00130 Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//PHD-finger//RING-H2 zinc finger//RING-variant domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0016567 intracellular signal transduction//protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0803 Predicted E3 ubiquitin ligase Cluster-8309.48343 BP_3 22.00 1.01 1340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48344 BP_3 91.66 0.69 6714 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.32996e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF03178//PF16954 CPSF A subunit region//Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0003676//GO:0015232 nucleic acid binding//heme transporter activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.48346 BP_3 891.79 10.22 4499 642931932 XP_973544.3 3188 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 6 [Tribolium castaneum]>gi|270012741|gb|EFA09189.1| structural maintenance of chromosomes 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9I7 1238 3.4e-134 Structural maintenance of chromosomes protein 6 OS=Xenopus laevis GN=smc6 PE=2 SV=1 PF01580//PF05557//PF00038//PF10473//PF16716//PF04108//PF13304//PF04632//PF04336 FtsK/SpoIIIE family//Mitotic checkpoint protein//Intermediate filament protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Bone marrow stromal antigen 2//Autophagy protein Apg17//AAA domain, putative AbiEii toxin, Type IV TA system//Fusaric acid resistance protein family//Protein of unknown function, DUF479 GO:0015940//GO:0006914//GO:0006810//GO:0007094//GO:0006633//GO:0051607 pantothenate biosynthetic process//autophagy//transport//mitotic spindle assembly checkpoint//fatty acid biosynthetic process//defense response to virus GO:0000166//GO:0005524//GO:0008770//GO:0005198//GO:0045502//GO:0008134//GO:0042803//GO:0003677 nucleotide binding//ATP binding//[acyl-carrier-protein] phosphodiesterase activity//structural molecule activity//dynein binding//transcription factor binding//protein homodimerization activity//DNA binding GO:0005882//GO:0030286//GO:0005886//GO:0005667 intermediate filament//dynein complex//plasma membrane//transcription factor complex KOG0250 DNA repair protein RAD18 (SMC family protein) Cluster-8309.48347 BP_3 369.35 10.23 2032 91094503 XP_971555.1 1652 3.6e-181 PREDICTED: tyrosine-protein kinase Fps85D isoform X2 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1070 4.6e-115 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF08702 Fibrinogen alpha/beta chain family GO:0051258//GO:0030168//GO:0007165 protein polymerization//platelet activation//signal transduction GO:0005102//GO:0030674 receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-8309.48349 BP_3 181.00 6.78 1579 478251183 ENN71659.1 1253 5.2e-135 hypothetical protein YQE_11757, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NWS8 603 5.1e-61 Required for meiotic nuclear division protein 1 homolog OS=Homo sapiens GN=RMND1 PE=1 SV=2 PF00540 gag gene protein p17 (matrix protein) -- -- GO:0005198 structural molecule activity -- -- KOG2861 Uncharacterized conserved protein Cluster-8309.48353 BP_3 111.01 0.45 12191 546678376 ERL89009.1 14533 0.0e+00 hypothetical protein D910_06387 [Dendroctonus ponderosae] 861437320 XM_013072408.1 160 6.34085e-75 PREDICTED: Heterocephalus glaber dynein, axonemal, heavy chain 5 (Dnah5), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q96JB1 10759 0.0e+00 Dynein heavy chain 8, axonemal OS=Homo sapiens GN=DNAH8 PE=1 SV=2 PF07728//PF09520//PF11112//PF00004//PF03028 AAA domain (dynein-related subfamily)//Type II restriction endonuclease, TdeIII//Pyocin activator protein PrtN//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor GO:0007018//GO:0006355//GO:0007017//GO:0009307//GO:0006308 microtubule-based movement//regulation of transcription, DNA-templated//microtubule-based process//DNA restriction-modification system//DNA catabolic process GO:0005524//GO:0003677//GO:0009036//GO:0003777//GO:0016887 ATP binding//DNA binding//Type II site-specific deoxyribonuclease activity//microtubule motor activity//ATPase activity GO:0030286//GO:0005874//GO:0009359 dynein complex//microtubule//Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.48356 BP_3 15.36 0.46 1914 642911402 XP_972355.3 753 6.0e-77 PREDICTED: probable G-protein coupled receptor CG31760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKA4 293 5.4e-25 Probable G-protein coupled receptor CG31760 OS=Drosophila melanogaster GN=CG31760 PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.48357 BP_3 6.00 1.22 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48361 BP_3 7.00 0.50 972 405967580 EKC32723.1 664 6.4e-67 Calnexin [Crassostrea gigas] 768311752 CP010980.1 966 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 Q6Q487 961 9.6e-103 Calnexin homolog OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=AFUA_4G12850 PE=2 SV=2 PF00262 Calreticulin family GO:0006457 protein folding GO:0005509//GO:0051082 calcium ion binding//unfolded protein binding GO:0005783 endoplasmic reticulum KOG0675 Calnexin Cluster-8309.48364 BP_3 10.71 0.45 1443 478250113 ENN70619.1 462 2.5e-43 hypothetical protein YQE_12793, partial [Dendroctonus ponderosae] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 396 4.6e-37 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.48366 BP_3 608.72 14.32 2341 478258657 ENN78707.1 891 7.3e-93 hypothetical protein YQE_04879, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48368 BP_3 51.03 0.42 6213 91077030 XP_967400.1 1924 3.2e-212 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1115 8.5e-120 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF00069//PF06293//PF03604//PF05028//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//DNA directed RNA polymerase, 7 kDa subunit//Poly (ADP-ribose) glycohydrolase (PARG)//Protein tyrosine kinase GO:0006206//GO:0005975//GO:0006351//GO:0006144//GO:0006468 pyrimidine nucleobase metabolic process//carbohydrate metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//protein phosphorylation GO:0016773//GO:0004649//GO:0004672//GO:0005524//GO:0003899//GO:0003677 phosphotransferase activity, alcohol group as acceptor//poly(ADP-ribose) glycohydrolase activity//protein kinase activity//ATP binding//DNA-directed RNA polymerase activity//DNA binding GO:0016020//GO:0005730 membrane//nucleolus KOG3087 Serine/threonine protein kinase Cluster-8309.48370 BP_3 14.75 0.32 2486 91092788 XP_974007.1 441 1.2e-40 PREDICTED: dual specificity protein phosphatase 10 [Tribolium castaneum]>gi|270014786|gb|EFA11234.1| hypothetical protein TcasGA2_TC010766 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q0IID7 252 4.0e-20 Dual specificity protein phosphatase 10 OS=Bos taurus GN=DUSP10 PE=2 SV=1 PF00782 Dual specificity phosphatase, catalytic domain GO:0035335//GO:0006570//GO:0006470 peptidyl-tyrosine dephosphorylation//tyrosine metabolic process//protein dephosphorylation GO:0017017//GO:0004725//GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1716 Dual specificity phosphatase Cluster-8309.48371 BP_3 26.52 0.81 1861 270003747 EFA00195.1 2141 6.6e-238 hypothetical protein TcasGA2_TC003020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 1440 5.2e-158 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.48374 BP_3 145.08 2.97 2643 642921021 XP_974765.2 814 7.0e-84 PREDICTED: uncharacterized protein LOC663634 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48375 BP_3 174.92 3.30 2848 642921021 XP_974765.2 814 7.6e-84 PREDICTED: uncharacterized protein LOC663634 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48378 BP_3 74.53 2.99 1492 546673846 ERL85378.1 430 1.3e-39 hypothetical protein D910_02798 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48379 BP_3 126.81 0.69 9211 642920699 XP_976218.2 542 8.5e-52 PREDICTED: mucin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726//PF04443 Transmembrane protein//Acyl-protein synthetase, LuxE GO:0008218 bioluminescence GO:0047474 long-chain fatty acid luciferin component ligase activity GO:0016021 integral component of membrane -- -- Cluster-8309.48380 BP_3 76.01 0.65 5919 546681959 ERL91955.1 566 9.0e-55 hypothetical protein D910_09278, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04443 Acyl-protein synthetase, LuxE GO:0008218 bioluminescence GO:0047474 long-chain fatty acid luciferin component ligase activity -- -- -- -- Cluster-8309.48381 BP_3 14924.95 72.85 10167 546681959 ERL91955.1 566 1.5e-54 hypothetical protein D910_09278, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04443 Acyl-protein synthetase, LuxE GO:0008218 bioluminescence GO:0047474 long-chain fatty acid luciferin component ligase activity -- -- -- -- Cluster-8309.48384 BP_3 8.00 0.96 695 734546771 KHN75220.1 216 4.0e-15 Plasma membrane proteolipid 3, partial [Toxocara canis] 768311753 CP010981.1 504 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- Q4HXT6 280 6.3e-24 Plasma membrane proteolipid 3 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) GN=PMP3 PE=3 SV=2 PF01679 Proteolipid membrane potential modulator -- -- -- -- GO:0016021 integral component of membrane KOG1773 Stress responsive protein Cluster-8309.48385 BP_3 36.38 0.49 3906 642932262 XP_008197037.1 3915 0.0e+00 PREDICTED: exosome complex exonuclease RRP44 [Tribolium castaneum]>gi|270012315|gb|EFA08763.1| hypothetical protein TcasGA2_TC006450 [Tribolium castaneum] 642932261 XM_008198815.1 534 0 PREDICTED: Tribolium castaneum exosome complex exonuclease RRP44 (LOC655788), mRNA K12585 DIS3, RRP44 exosome complex exonuclease DIS3/RRP44 http://www.genome.jp/dbget-bin/www_bget?ko:K12585 Q9Y2L1 2562 8.7e-288 Exosome complex exonuclease RRP44 OS=Homo sapiens GN=DIS3 PE=1 SV=2 -- -- GO:0051252 regulation of RNA metabolic process GO:0004540//GO:0003723 ribonuclease activity//RNA binding -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-8309.48387 BP_3 169.00 4.35 2165 -- -- -- -- -- 642913530 XM_966293.2 135 8.78019e-62 PREDICTED: Tribolium castaneum methyl-CpG-binding domain protein 5 (LOC660029), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48390 BP_3 1.00 0.98 333 91078968 XP_974347.1 164 2.1e-09 PREDICTED: 60S ribosomal protein L7 [Tribolium castaneum]>gi|270003687|gb|EFA00135.1| hypothetical protein TcasGA2_TC002951 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48391 BP_3 388.62 2.32 8351 86515334 NP_001034492.1 4335 0.0e+00 chitin synthase 2 [Tribolium castaneum]>gi|33867321|gb|AAQ55061.1| chitin synthase CHS2 [Tribolium castaneum]>gi|34148365|gb|AAQ62692.1| chitin synthase [Tribolium castaneum]>gi|270014271|gb|EFA10719.1| chitin synthase 2 [Tribolium castaneum] -- -- -- -- -- K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q9H3F6 946 4.5e-100 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens GN=KCTD10 PE=1 SV=1 PF02186//PF00651//PF03233//PF02214 TFIIE beta subunit core domain//BTB/POZ domain//Aphid transmission protein//BTB/POZ domain GO:0051260//GO:0006367//GO:0019089 protein homooligomerization//transcription initiation from RNA polymerase II promoter//transmission of virus GO:0005515//GO:0016757 protein binding//transferase activity, transferring glycosyl groups -- -- KOG2716 Polymerase delta-interacting protein PDIP1 and related proteins, contain BTB/POZ domain Cluster-8309.48392 BP_3 19.00 4.19 510 546685505 ERL95003.1 230 7.0e-17 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06455 NADH dehydrogenase subunit 5 C-terminus GO:0006814//GO:0042773//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ATP synthesis coupled electron transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-8309.48394 BP_3 2021.39 37.06 2921 91084489 XP_971806.1 713 4.0e-72 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103 CD20-like family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48395 BP_3 1763.90 13.55 6564 332373456 AEE61869.1 1731 8.1e-190 unknown [Dendroctonus ponderosae]>gi|478257157|gb|ENN77320.1| hypothetical protein YQE_06146, partial [Dendroctonus ponderosae] 701345709 XM_009975740.1 83 2.16873e-32 PREDICTED: Tyto alba UDP-glucuronic acid decarboxylase 1 (LOC104368417), partial mRNA K08678 UXS1, uxs UDP-glucuronate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K08678 Q6DF08 1329 1.4e-144 UDP-glucuronic acid decarboxylase 1 OS=Xenopus tropicalis GN=uxs1 PE=2 SV=1 PF01073//PF00293//PF00106//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NUDIX domain//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 metabolic process//estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003854//GO:0050662//GO:0003824//GO:0016787 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//hydrolase activity -- -- KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase Cluster-8309.48396 BP_3 87.16 1.00 4476 642922521 XP_008193210.1 2779 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1116 4.7e-120 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF02985//PF00514 HEAT repeat//Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.48398 BP_3 415.20 2.81 7414 642939438 XP_008200391.1 4034 0.0e+00 PREDICTED: maternal protein pumilio isoform X4 [Tribolium castaneum] 642939437 XM_008202169.1 658 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X4, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806//PF02422 CPL (NUC119) domain//Pumilio-family RNA binding repeat//Keratin -- -- GO:0003723//GO:0005200 RNA binding//structural constituent of cytoskeleton GO:0005856//GO:0005882 cytoskeleton//intermediate filament KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.48399 BP_3 40.75 0.40 5179 642933730 XP_008197339.1 4351 0.0e+00 PREDICTED: transmembrane protein 132B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q14DG7 701 7.2e-72 Transmembrane protein 132B OS=Homo sapiens GN=TMEM132B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4789 Uncharacterized conserved protein Cluster-8309.484 BP_3 6.53 0.84 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48400 BP_3 3.73 0.52 637 514683686 XP_004989424.1 196 7.7e-13 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- Q642B9 135 3.8e-07 Zinc finger protein 18 OS=Rattus norvegicus GN=Znf18 PE=2 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.48401 BP_3 2.00 1.78 339 676469219 XP_009058461.1 162 3.6e-09 hypothetical protein LOTGIDRAFT_122614, partial [Lottia gigantea]>gi|556102154|gb|ESO90806.1| hypothetical protein LOTGIDRAFT_122614, partial [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04810//PF13465//PF00096//PF02150 Sec23/Sec24 zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//RNA polymerases M/15 Kd subunit GO:0006144//GO:0006886//GO:0006888//GO:0006351//GO:0006206 purine nucleobase metabolic process//intracellular protein transport//ER to Golgi vesicle-mediated transport//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0046872//GO:0008270 DNA-directed RNA polymerase activity//DNA binding//metal ion binding//zinc ion binding GO:0030127//GO:0005730 COPII vesicle coat//nucleolus -- -- Cluster-8309.48403 BP_3 27.32 0.34 4164 270008325 EFA04773.1 1797 1.1e-197 hypothetical protein TcasGA2_TC030724 [Tribolium castaneum] 170040110 XM_001847803.1 270 1.52982e-136 Culex quinquefasciatus elongation factor G 1, mitochondrial, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 B0WGM1 1688 2.1e-186 Elongation factor G, mitochondrial OS=Culex quinquefasciatus GN=CPIJ005834 PE=3 SV=1 PF10461//PF03764//PF05485//PF03144 Peptidase S68//Elongation factor G, domain IV//THAP domain//Elongation factor Tu domain 2 GO:0006915//GO:0006974 apoptotic process//cellular response to DNA damage stimulus GO:0003676//GO:0005525 nucleic acid binding//GTP binding -- -- KOG0465 Mitochondrial elongation factor Cluster-8309.48405 BP_3 7.28 0.47 1041 189234912 XP_969611.2 383 2.6e-34 PREDICTED: poly(rC)-binding protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 P57721 297 1.0e-25 Poly(rC)-binding protein 3 OS=Homo sapiens GN=PCBP3 PE=2 SV=2 PF13014//PF00013//PF07650 KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2190 PolyC-binding proteins alphaCP-1 and related KH domain proteins Cluster-8309.48406 BP_3 79.35 0.59 6822 546676860 ERL87797.1 1674 3.4e-183 hypothetical protein D910_05186 [Dendroctonus ponderosae] 512862182 XM_002935331.2 57 6.40269e-18 PREDICTED: Xenopus (Silurana) tropicalis enhancer of rudimentary homolog (Drosophila) (erh), mRNA -- -- -- -- Q8NBJ9 1125 6.5e-121 SID1 transmembrane family member 2 OS=Homo sapiens GN=SIDT2 PE=1 SV=2 PF13965//PF00175//PF01133//PF00097//PF08030 dsRNA-gated channel SID-1//Oxidoreductase NAD-binding domain//Enhancer of rudimentary//Zinc finger, C3HC4 type (RING finger)//Ferric reductase NAD binding domain GO:0045747//GO:0015931//GO:0006221//GO:0033227//GO:0007049//GO:0055114 positive regulation of Notch signaling pathway//nucleobase-containing compound transport//pyrimidine nucleotide biosynthetic process//dsRNA transport//cell cycle//oxidation-reduction process GO:0016491//GO:0051033//GO:0046872 oxidoreductase activity//RNA transmembrane transporter activity//metal ion binding GO:0016021 integral component of membrane KOG1766 Enhancer of rudimentary Cluster-8309.48407 BP_3 624.79 8.55 3815 642935249 XP_008197930.1 1729 8.0e-190 PREDICTED: cdk10/11-like protein isoform X1 [Tribolium castaneum] 808133727 XM_012313986.1 209 1.13761e-102 PREDICTED: Bombus terrestris cyclin-dependent kinase 11B (LOC100650971), transcript variant X6, mRNA K08818 CDC2L cell division cycle 2-like http://www.genome.jp/dbget-bin/www_bget?ko:K08818 Q9VPC0 1397 1.0e-152 Serine/threonine-protein kinase PITSLRE OS=Drosophila melanogaster GN=Pitslre PE=1 SV=1 PF00069//PF01166//PF07714//PF05324 Protein kinase domain//TSC-22/dip/bun family//Protein tyrosine kinase//Sperm antigen HE2 GO:0006355//GO:0006468 regulation of transcription, DNA-templated//protein phosphorylation GO:0005524//GO:0003700//GO:0004672 ATP binding//transcription factor activity, sequence-specific DNA binding//protein kinase activity GO:0005576//GO:0005667 extracellular region//transcription factor complex -- -- Cluster-8309.48409 BP_3 117.76 1.84 3378 642915652 XP_008190697.1 1174 1.6e-125 PREDICTED: integrin-alpha FG-GAP repeat-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- K09648 IMP2 mitochondrial inner membrane protease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09648 Q6AZD4 491 1.0e-47 Mitochondrial inner membrane protease subunit 2 OS=Danio rerio GN=immp2l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1568 Mitochondrial inner membrane protease, subunit IMP2 Cluster-8309.4841 BP_3 1.00 11.75 239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48411 BP_3 482.59 16.91 1667 642918656 XP_008191524.1 1896 1.5e-209 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 1716 4.6e-190 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005543//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phospholipid binding//ATP binding -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.48413 BP_3 34.58 1.02 1922 642928714 XP_973858.2 1169 3.5e-125 PREDICTED: venom serine protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQS8 716 4.8e-74 Venom serine protease 34 OS=Apis mellifera PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.48414 BP_3 12.63 0.49 1533 642936242 XP_008198362.1 1627 2.2e-178 PREDICTED: polypyrimidine tract-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 781 1.1e-81 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.48415 BP_3 438.44 4.98 4534 270013160 EFA09608.1 920 6.2e-96 hypothetical protein TcasGA2_TC011728 [Tribolium castaneum] 642936249 XM_008200144.1 221 2.88982e-109 PREDICTED: Tribolium castaneum polypyrimidine tract-binding protein 1 (LOC654951), transcript variant X5, mRNA K14948 PTBP2, NPTB polypyrimidine tract-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14948 Q00438 675 6.5e-69 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF08675//PF01405//PF00076 RNA binding domain//Photosystem II reaction centre T protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0051252//GO:0006402//GO:0015979 regulation of RNA metabolic process//mRNA catabolic process//photosynthesis GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0016020//GO:0009539//GO:0005737//GO:0009523//GO:0005634 membrane//photosystem II reaction center//cytoplasm//photosystem II//nucleus KOG1190 Polypyrimidine tract-binding protein Cluster-8309.48416 BP_3 353.27 17.26 1278 642936244 XP_008198363.1 1656 7.8e-182 PREDICTED: polypyrimidine tract-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 769 2.3e-80 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.48421 BP_3 362.53 2.08 8679 560135523 CDJ84245.1 2273 1.5e-252 Protein of unknown function DUF889 domain containing protein [Haemonchus contortus] -- -- -- -- -- -- -- -- -- Q7ZV90 255 6.3e-20 ATP-dependent DNA helicase PIF1 OS=Danio rerio GN=pif1 PE=2 SV=1 PF02689//PF01443//PF05970 Helicase//Viral (Superfamily 1) RNA helicase//PIF1-like helicase GO:0000723//GO:0006281 telomere maintenance//DNA repair GO:0005524//GO:0003678//GO:0004386 ATP binding//DNA helicase activity//helicase activity GO:0005657 replication fork -- -- Cluster-8309.48424 BP_3 268.00 8.89 1745 270016741 EFA13187.1 182 8.9e-11 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48425 BP_3 55.00 4.39 896 478254217 ENN74482.1 186 1.6e-11 hypothetical protein YQE_08928, partial [Dendroctonus ponderosae]>gi|546675251|gb|ERL86487.1| hypothetical protein D910_03891 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P23625 144 4.8e-08 G protein alpha q subunit OS=Drosophila melanogaster GN=Galphaq PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.48427 BP_3 67.41 1.25 2886 91081333 XP_976019.1 2826 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X1 [Tribolium castaneum] -- -- -- -- -- K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 2119 1.5e-236 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 PF07525//PF17050 SOCS box//Altered inheritance of mitochondria 5 GO:0042407//GO:0035556 cristae formation//intracellular signal transduction -- -- GO:0044284//GO:0061617 mitochondrial crista junction//MICOS complex KOG3635 Phosphorylase kinase Cluster-8309.48429 BP_3 22.40 0.32 3699 91081335 XP_967042.1 4384 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X2 [Tribolium castaneum]>gi|270005182|gb|EFA01630.1| hypothetical protein TcasGA2_TC007200 [Tribolium castaneum] 820837636 XM_012494483.1 538 0 PREDICTED: Apis florea probable phosphorylase b kinase regulatory subunit alpha (LOC100865608), transcript variant X3, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 3632 0.0e+00 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 -- -- GO:0005975//GO:0005977 carbohydrate metabolic process//glycogen metabolic process GO:0005516//GO:0004553 calmodulin binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG3635 Phosphorylase kinase Cluster-8309.48432 BP_3 21.52 0.31 3684 642920126 XP_008192217.1 1477 1.3e-160 PREDICTED: microtubule-associated protein futsch isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q869E1 144 2.0e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 PF01537 Herpesvirus glycoprotein D/GG/GX domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48434 BP_3 154.08 3.68 2309 -- -- -- -- -- 642920079 XM_001815999.2 51 4.64791e-15 PREDICTED: Tribolium castaneum uncharacterized LOC100142030 (LOC100142030), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48435 BP_3 207.75 4.86 2352 -- -- -- -- -- 642920079 XM_001815999.2 51 4.7358e-15 PREDICTED: Tribolium castaneum uncharacterized LOC100142030 (LOC100142030), mRNA -- -- -- -- -- -- -- -- PF02751 Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.48438 BP_3 69.32 0.78 4589 390362249 XP_001190749.2 841 9.0e-87 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 831 5.4e-87 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.48441 BP_3 11.21 0.33 1906 546671410 ERL83733.1 737 4.3e-75 hypothetical protein D910_00946 [Dendroctonus ponderosae]>gi|546671482|gb|ERL83777.1| hypothetical protein D910_01015 [Dendroctonus ponderosae]>gi|546671488|gb|ERL83781.1| hypothetical protein D910_01019 [Dendroctonus ponderosae] -- -- -- -- -- K10990 RMI1, BRAP75 RecQ-mediated genome instability protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10990 Q7ZVM9 410 1.5e-38 RecQ-mediated genome instability protein 1 OS=Danio rerio GN=rmi1 PE=2 SV=1 PF16099 Recq-mediated genome instability protein 1, C-terminal OB-fold -- -- GO:0000166 nucleotide binding -- -- KOG3683 Uncharacterized conserved protein Cluster-8309.48443 BP_3 327.00 25.25 916 478253497 ENN73824.1 519 3.9e-50 hypothetical protein YQE_09602, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V3W6 304 1.4e-26 Innexin inx7 OS=Drosophila melanogaster GN=Inx7 PE=2 SV=1 PF00876//PF01553 Innexin//Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups GO:0005921 gap junction -- -- Cluster-8309.48444 BP_3 23.19 0.34 3585 642916660 XP_008192067.1 3717 0.0e+00 PREDICTED: serine/threonine-protein kinase N isoform X3 [Tribolium castaneum] 242022369 XM_002431568.1 129 3.16574e-58 Pediculus humanus corporis conserved hypothetical protein, mRNA K06071 PKN protein kinase N http://www.genome.jp/dbget-bin/www_bget?ko:K06071 Q16513 2138 1.2e-238 Serine/threonine-protein kinase N2 OS=Homo sapiens GN=PKN2 PE=1 SV=1 PF07714//PF00069//PF02185 Protein tyrosine kinase//Protein kinase domain//Hr1 repeat GO:0007165//GO:0006468 signal transduction//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.48448 BP_3 249.05 12.25 1272 189241858 XP_971116.2 1391 4.2e-151 PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 P59644 534 4.1e-53 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Mus musculus GN=Inpp5j PE=2 SV=2 PF06330 Trichodiene synthase (TRI5) GO:0016114//GO:0016106 terpenoid biosynthetic process//sesquiterpenoid biosynthetic process GO:0045482 trichodiene synthase activity -- -- -- -- Cluster-8309.4845 BP_3 20.00 0.52 2136 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48450 BP_3 70.03 0.91 4020 642930094 XP_008196249.1 1125 9.2e-120 PREDICTED: uncharacterized protein LOC655867 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03610 212 2.8e-15 Uncharacterized protein ZC84.1 OS=Caenorhabditis elegans GN=ZC84.1 PE=3 SV=6 PF02822//PF00014 Antistasin family//Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.48451 BP_3 236.65 2.94 4172 270015450 EFA11898.1 376 6.8e-33 hypothetical protein TcasGA2_TC001429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07646 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48453 BP_3 72.84 1.16 3314 478267817 ENN83104.1 334 4.0e-28 hypothetical protein YQE_00535, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07646 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48455 BP_3 146.14 1.25 5946 270003786 EFA00234.1 3989 0.0e+00 hypothetical protein TcasGA2_TC003062 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.31264e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2082 6.0e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.48457 BP_3 12.14 0.43 1654 478256576 ENN76758.1 216 9.7e-15 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48459 BP_3 721.02 3.51 10191 478256576 ENN76758.1 3630 0.0e+00 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- K10395 KIF4_21_27 kinesin family member 4/21/27 http://www.genome.jp/dbget-bin/www_bget?ko:K10395 Q7Z4S6 1645 4.9e-181 Kinesin-like protein KIF21A OS=Homo sapiens GN=KIF21A PE=1 SV=2 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0003777//GO:0008017//GO:0005524 microtubule motor activity//microtubule binding//ATP binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG2408 Peroxidase/oxygenase Cluster-8309.48460 BP_3 435.40 2.11 10245 478256576 ENN76758.1 3630 0.0e+00 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- K10395 KIF4_21_27 kinesin family member 4/21/27 http://www.genome.jp/dbget-bin/www_bget?ko:K10395 Q7Z4S6 1645 4.9e-181 Kinesin-like protein KIF21A OS=Homo sapiens GN=KIF21A PE=1 SV=2 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule KOG0244 Kinesin-like protein Cluster-8309.48461 BP_3 254.47 4.51 3010 642927168 XP_008195164.1 1378 3.2e-149 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZI58 629 9.3e-64 Protein FAM214A OS=Gallus gallus GN=FAM214A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2306 Uncharacterized conserved protein Cluster-8309.48463 BP_3 848.53 3.76 11174 91079222 XP_970170.1 5671 0.0e+00 PREDICTED: calcineurin-binding protein cabin-1 [Tribolium castaneum]>gi|270004269|gb|EFA00717.1| hypothetical protein TcasGA2_TC003597 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 714 4.8e-73 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF00096//PF03608//PF04882//PF04828//PF00320//PF01363//PF13912//PF17051//PF13414//PF13465//PF13176//PF05191//PF16622//PF02892//PF00515//PF09726 Zinc finger, C2H2 type//PTS system enzyme II sorbitol-specific factor//Peroxin-3//Glutathione-dependent formaldehyde-activating enzyme//GATA zinc finger//FYVE zinc finger//C2H2-type zinc finger//Cytochrome C oxidase assembly factor 2//TPR repeat//Zinc-finger double domain//Tetratricopeptide repeat//Adenylate kinase, active site lid//zinc-finger C2H2-type//BED zinc finger//Tetratricopeptide repeat//Transmembrane protein GO:0046034//GO:0006355//GO:0009401//GO:0008152//GO:0007031//GO:0006144//GO:0033617 ATP metabolic process//regulation of transcription, DNA-templated//phosphoenolpyruvate-dependent sugar phosphotransferase system//metabolic process//peroxisome organization//purine nucleobase metabolic process//mitochondrial respiratory chain complex IV assembly GO:0016846//GO:0008270//GO:0043565//GO:0003700//GO:0004017//GO:0003677//GO:0005515//GO:0046872 carbon-sulfur lyase activity//zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//adenylate kinase activity//DNA binding//protein binding//metal ion binding GO:0016021//GO:0005779//GO:0005667 integral component of membrane//integral component of peroxisomal membrane//transcription factor complex -- -- Cluster-8309.48465 BP_3 15.01 0.41 2046 642933823 XP_008197408.1 1644 3.1e-180 PREDICTED: formin-2 [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 776 5.7e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.48466 BP_3 52.19 0.40 6618 642928875 XP_970065.3 3498 0.0e+00 PREDICTED: nuclear pore membrane glycoprotein 210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEM1 1169 4.9e-126 Nuclear pore membrane glycoprotein 210 OS=Homo sapiens GN=NUP210 PE=1 SV=3 PF01509 TruB family pseudouridylate synthase (N terminal domain) GO:0006396 RNA processing -- -- -- -- KOG1833 Nuclear pore complex, gp210 component Cluster-8309.48468 BP_3 1386.50 10.30 6779 546684555 ERL94183.1 5855 0.0e+00 hypothetical protein D910_11465 [Dendroctonus ponderosae] 642931708 XM_008198474.1 214 3.37118e-105 PREDICTED: Tribolium castaneum golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (LOC655455), mRNA K18443 GBF1 golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18443 Q9R1D7 1809 3.1e-200 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Cricetulus griseus GN=GBF1 PE=1 SV=1 PF01369 Sec7 domain GO:0043087//GO:0032012 regulation of GTPase activity//regulation of ARF protein signal transduction GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0928 Pattern-formation protein/guanine nucleotide exchange factor Cluster-8309.48469 BP_3 100.78 4.81 1301 478250432 ENN70927.1 524 1.5e-50 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 438 5.6e-42 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656//PF00522 Caspase domain//VPR/VPX protein GO:0006508//GO:0019058 proteolysis//viral life cycle GO:0004197 cysteine-type endopeptidase activity GO:0042025 host cell nucleus -- -- Cluster-8309.48472 BP_3 586.00 10.27 3041 478254047 ENN74339.1 1183 1.3e-126 hypothetical protein YQE_09309, partial [Dendroctonus ponderosae]>gi|546686139|gb|ERL95525.1| hypothetical protein D910_12787 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 680 1.1e-69 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF07284//PF07690//PF03137//PF00083 2-vinyl bacteriochlorophyllide hydratase (BCHF)//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Sugar (and other) transporter GO:0055085//GO:0019685//GO:0006810//GO:0030494 transmembrane transport//photosynthesis, dark reaction//transport//bacteriochlorophyll biosynthetic process GO:0022857//GO:0016836//GO:0005215 transmembrane transporter activity//hydro-lyase activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.48475 BP_3 135.99 2.01 3547 642915923 XP_008190812.1 3396 0.0e+00 PREDICTED: protein retinal degeneration B isoform X4 [Tribolium castaneum] 642915920 XM_008192589.1 55 4.2872e-17 PREDICTED: Tribolium castaneum protein retinal degeneration B (LOC655106), transcript variant X5, mRNA -- -- -- -- P43125 2320 9.1e-260 Protein retinal degeneration B OS=Drosophila melanogaster GN=rdgB PE=1 SV=2 PF03767//PF02862 HAD superfamily, subfamily IIIB (Acid phosphatase)//DDHD domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0003993 metal ion binding//acid phosphatase activity -- -- KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.48477 BP_3 40.78 0.40 5260 390362249 XP_001190749.2 801 4.5e-82 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 734 1.1e-75 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF12537//PF00023//PF06451//PF13606 The Golgi pH Regulator (GPHR) Family N-terminal//Ankyrin repeat//Moricin//Ankyrin repeat GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0016020//GO:0005576 membrane//extracellular region KOG4177 Ankyrin Cluster-8309.48478 BP_3 1.00 10.47 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48481 BP_3 154.36 1.59 4965 642932399 XP_001812551.2 1590 1.4e-173 PREDICTED: uncharacterized protein LOC100142041 [Tribolium castaneum] 642932398 XM_001812499.2 48 4.68576e-13 PREDICTED: Tribolium castaneum uncharacterized LOC100142041 (LOC100142041), mRNA K17895 GATA3 GATA-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17895 P46152 200 8.5e-14 Transcription factor GATA-4 OS=Rattus norvegicus GN=Gata4 PE=1 SV=1 PF00320//PF07776//PF00979 GATA zinc finger//Zinc-finger associated domain (zf-AD)//Reovirus outer capsid protein, Sigma 3 GO:0019058//GO:0006355 viral life cycle//regulation of transcription, DNA-templated GO:0005198//GO:0003700//GO:0043565//GO:0008270 structural molecule activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.48482 BP_3 73.96 0.76 4987 642932399 XP_001812551.2 1585 5.2e-173 PREDICTED: uncharacterized protein LOC100142041 [Tribolium castaneum] 642932398 XM_001812499.2 48 4.70668e-13 PREDICTED: Tribolium castaneum uncharacterized LOC100142041 (LOC100142041), mRNA K17895 GATA3 GATA-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17895 P43694 207 1.3e-14 Transcription factor GATA-4 OS=Homo sapiens GN=GATA4 PE=1 SV=2 PF00979//PF00320//PF07776 Reovirus outer capsid protein, Sigma 3//GATA zinc finger//Zinc-finger associated domain (zf-AD) GO:0019058//GO:0006355 viral life cycle//regulation of transcription, DNA-templated GO:0005198//GO:0003700//GO:0008270//GO:0043565 structural molecule activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.48485 BP_3 67.19 0.52 6542 91089043 XP_969794.1 4704 0.0e+00 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] 657579724 XM_008295570.1 270 2.40998e-136 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 3158 0.0e+00 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF06384//PF02985//PF00400 Beta-catenin-interacting protein ICAT//HEAT repeat//WD domain, G-beta repeat -- -- GO:0005515//GO:0008013 protein binding//beta-catenin binding GO:0016342 catenin complex KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.48486 BP_3 55.03 1.82 1753 769831193 XP_011634997.1 1643 3.5e-180 PREDICTED: synaptotagmin-7 isoform X1 [Pogonomyrmex barbatus] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 871 4.7e-92 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.48487 BP_3 1095.56 6.97 7864 478255473 ENN75692.1 1601 1.2e-174 hypothetical protein YQE_07754, partial [Dendroctonus ponderosae] 642937067 XM_008200455.1 308 2.1791e-157 PREDICTED: Tribolium castaneum collagen alpha chain CG42342 (LOC659070), transcript variant X4, mRNA -- -- -- -- B7Z0K8 216 1.9e-15 Collagen alpha chain CG42342 OS=Drosophila melanogaster GN=CG42342 PE=2 SV=1 PF01757//PF17123//PF17122//PF13639 Acyltransferase family//RING-like zinc finger//Zinc-finger//Ring finger domain -- -- GO:0005515//GO:0016747//GO:0008270 protein binding//transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- -- -- Cluster-8309.48488 BP_3 1345.43 8.39 8019 642937088 XP_008198687.1 1740 9.0e-191 PREDICTED: nose resistant to fluoxetine protein 6 isoform X1 [Tribolium castaneum]>gi|270000892|gb|EEZ97339.1| hypothetical protein TcasGA2_TC011151 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B7Z0K8 181 2.2e-11 Collagen alpha chain CG42342 OS=Drosophila melanogaster GN=CG42342 PE=2 SV=1 PF13639//PF01757//PF17123//PF17122 Ring finger domain//Acyltransferase family//RING-like zinc finger//Zinc-finger -- -- GO:0016747//GO:0005515//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//zinc ion binding -- -- -- -- Cluster-8309.48491 BP_3 324.27 2.69 6096 642937213 XP_008198742.1 1736 2.0e-190 PREDICTED: activin receptor type-2A [Tribolium castaneum]>gi|270001287|gb|EEZ97734.1| punt [Tribolium castaneum] 852789879 XM_013030253.1 144 2.47964e-66 PREDICTED: Dipodomys ordii activin A receptor, type IIB (Acvr2b), mRNA K13596 ACVR2B activin receptor type-2B http://www.genome.jp/dbget-bin/www_bget?ko:K13596 P27039 1135 4.0e-122 Activin receptor type-2A OS=Xenopus laevis GN=acvr2a PE=2 SV=1 PF16782//PF01064//PF00069//PF07714 Nucleotide exchange factor SIL1//Activin types I and II receptor domain//Protein kinase domain//Protein tyrosine kinase GO:0007178//GO:0016310//GO:0006468//GO:0009069 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0000774//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//adenyl-nucleotide exchange factor activity//protein kinase activity//ATP binding GO:0016020//GO:0005783 membrane//endoplasmic reticulum -- -- Cluster-8309.48493 BP_3 684.00 60.91 833 642917962 XP_008198961.1 846 4.3e-88 PREDICTED: probable phospholipid hydroperoxide glutathione peroxidase [Tribolium castaneum]>gi|270004924|gb|EFA01372.1| hypothetical protein TcasGA2_TC010362 [Tribolium castaneum] 512938538 XM_004933972.1 53 1.26286e-16 PREDICTED: Bombyx mori phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like (LOC101744684), partial mRNA K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q32QL6 485 1.3e-47 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial OS=Callithrix jacchus GN=GPX4 PE=2 SV=2 PF00255//PF00578//PF11095//PF08534 Glutathione peroxidase//AhpC/TSA family//Gem-associated protein 7 (Gemin7)//Redoxin GO:0006804//GO:0006979//GO:0006749//GO:0055114 obsolete peroxidase reaction//response to oxidative stress//glutathione metabolic process//oxidation-reduction process GO:0016491//GO:0004602//GO:0016209 oxidoreductase activity//glutathione peroxidase activity//antioxidant activity GO:0032797 SMN complex KOG1651 Glutathione peroxidase Cluster-8309.48498 BP_3 146.36 4.77 1770 642928567 XP_008199961.1 576 1.9e-56 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 384 1.4e-35 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.48502 BP_3 42.76 0.39 5514 815769352 XP_012234789.1 1751 3.3e-192 PREDICTED: synaptotagmin-7 isoform X1 [Linepithema humile]>gi|815769354|ref|XP_012234790.1| PREDICTED: synaptotagmin-7 isoform X1 [Linepithema humile] 768417764 XM_011551234.1 440 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 876 3.9e-92 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168//PF04545 C2 domain//Sigma-70, region 4 GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0003700//GO:0005515 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005667 transcription factor complex KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.48504 BP_3 711.48 8.68 4244 642910515 XP_971774.3 2651 1.1e-296 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] 642910514 XM_966681.3 50 3.09246e-14 PREDICTED: Tribolium castaneum leucine-rich repeats and immunoglobulin-like domains protein 2 (LOC660451), transcript variant X2, mRNA -- -- -- -- Q52KR2 1478 4.7e-162 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Mus musculus GN=Lrig2 PE=1 SV=1 PF13895//PF13855//PF06667//PF00560//PF02924//PF05790 Immunoglobulin domain//Leucine rich repeat//Phage shock protein B//Leucine Rich Repeat//Bacteriophage lambda head decoration protein D//Immunoglobulin C2-set domain GO:0007155//GO:0006355//GO:0009271 cell adhesion//regulation of transcription, DNA-templated//phage shock GO:0005515 protein binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG4194 Membrane glycoprotein LIG-1 Cluster-8309.48505 BP_3 98.55 2.01 2649 751425407 AJF93909.1 2405 2.3e-268 FTZ F1 beta [Leptinotarsa decemlineata] 642917898 XM_008193153.1 817 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X3, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1653 1.5e-182 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00105//PF00104//PF00288 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor//GHMP kinases N terminal domain GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0005524//GO:0003700//GO:0008270//GO:0043565 ATP binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.48506 BP_3 1.00 7.80 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48507 BP_3 27.49 0.93 1716 642932088 XP_975105.3 656 9.5e-66 PREDICTED: acid phosphatase-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IHQ9 220 1.4e-16 2-phosphoxylose phosphatase 1 OS=Xenopus tropicalis GN=pxylp1 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3672 Histidine acid phosphatase Cluster-8309.48509 BP_3 134.39 1.97 3585 546677956 ERL88689.1 429 4.2e-39 hypothetical protein D910_06072 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03547//PF05485 Membrane transport protein//THAP domain GO:0055085 transmembrane transport GO:0003676 nucleic acid binding GO:0016021 integral component of membrane -- -- Cluster-8309.48510 BP_3 25.61 0.37 3634 546677956 ERL88689.1 226 1.5e-15 hypothetical protein D910_06072 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03547//PF05485 Membrane transport protein//THAP domain GO:0055085 transmembrane transport GO:0003676 nucleic acid binding GO:0016021 integral component of membrane -- -- Cluster-8309.48511 BP_3 1053.00 39.03 1592 332374872 AEE62577.1 1421 1.7e-154 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03843 ALG2 alpha-1,3/alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03843 Q9H553 880 3.9e-93 Alpha-1,3/1,6-mannosyltransferase ALG2 OS=Homo sapiens GN=ALG2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0853 Glycosyltransferase Cluster-8309.48512 BP_3 635.00 149.69 496 668465859 KFB52933.1 491 3.7e-47 AGAP005873-PA-like protein [Anopheles sinensis] 242007912 XM_002424715.1 111 4.1928e-49 Pediculus humanus corporis DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide, putative, mRNA K03014 RPB6, POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03014 Q24320 469 5.5e-46 DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Drosophila melanogaster GN=RpII18 PE=2 SV=1 PF01192 RNA polymerase Rpb6 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG3405 RNA polymerase subunit K Cluster-8309.48516 BP_3 31.09 3.05 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48520 BP_3 704.32 5.61 6344 642929348 XP_008195797.1 4359 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1583 4.7e-174 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF00787//PF00498//PF00225 PX domain//FHA domain//Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0003777//GO:0005515//GO:0035091//GO:0008017 ATP binding//microtubule motor activity//protein binding//phosphatidylinositol binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.48521 BP_3 8.85 0.33 1588 642937136 XP_008198708.1 276 1.0e-21 PREDICTED: arginine/serine-rich protein PNISR [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04441 Poxvirus early transcription factor (VETF), large subunit GO:0045893 positive regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.48522 BP_3 109.88 1.02 5502 642939323 XP_969087.2 928 8.8e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.76952e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01588 Putative tRNA binding domain -- -- GO:0000049 tRNA binding -- -- KOG2241 tRNA-binding protein Cluster-8309.48523 BP_3 145.04 1.66 4506 642937136 XP_008198708.1 682 2.4e-68 PREDICTED: arginine/serine-rich protein PNISR [Tribolium castaneum] 826415001 XM_012666755.1 37 5.53599e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K13170 SFRS18 splicing factor, arginine/serine-rich 18 http://www.genome.jp/dbget-bin/www_bget?ko:K13170 Q8TF01 234 8.9e-18 Arginine/serine-rich protein PNISR OS=Homo sapiens GN=PNISR PE=1 SV=2 PF01956//PF02724 Integral membrane protein DUF106//CDC45-like protein GO:0006270 DNA replication initiation -- -- GO:0016020 membrane -- -- Cluster-8309.48524 BP_3 5.04 0.31 1072 270004118 EFA00566.1 451 3.5e-42 hypothetical protein TcasGA2_TC003436 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 399 1.5e-37 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.48525 BP_3 53.97 1.09 2680 642911304 XP_008199362.1 270 8.6e-21 PREDICTED: uncharacterized protein LOC103314645 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48526 BP_3 528.32 2.13 12221 642938657 XP_008197674.1 3758 0.0e+00 PREDICTED: probable G-protein coupled receptor 125 [Tribolium castaneum] -- -- -- -- -- K09478 ACADSB short/branched chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09478 P45954 1254 1.3e-135 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1 PF02793//PF01825//PF00441//PF13895//PF13855//PF02771//PF02770//PF00002 Hormone receptor domain//GPCR proteolysis site, GPS, motif//Acyl-CoA dehydrogenase, C-terminal domain//Immunoglobulin domain//Leucine rich repeat//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//7 transmembrane receptor (Secretin family) GO:0055114//GO:0006118//GO:0007186//GO:0008152 oxidation-reduction process//obsolete electron transport//G-protein coupled receptor signaling pathway//metabolic process GO:0016627//GO:0050660//GO:0005515//GO:0003995//GO:0004930 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//protein binding//acyl-CoA dehydrogenase activity//G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.48527 BP_3 1464.21 30.80 2583 91088011 XP_973916.1 309 2.5e-25 PREDICTED: 40S ribosomal protein S26 [Tribolium castaneum]>gi|270011893|gb|EFA08341.1| hypothetical protein TcasGA2_TC005984 [Tribolium castaneum] -- -- -- -- -- K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 P13008 282 1.4e-23 40S ribosomal protein S26 OS=Drosophila melanogaster GN=RpS26 PE=1 SV=1 PF02817//PF15473 e3 binding domain//PEST, proteolytic signal-containing nuclear protein family GO:0008152//GO:0042254//GO:0006412//GO:0016567 metabolic process//ribosome biogenesis//translation//protein ubiquitination GO:0003735//GO:0016746 structural constituent of ribosome//transferase activity, transferring acyl groups GO:0005840 ribosome KOG1768 40s ribosomal protein S26 Cluster-8309.48529 BP_3 85.75 0.87 5038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4853 BP_3 28.00 1.17 1442 795020586 XP_011859972.1 231 1.5e-16 PREDICTED: uncharacterized protein LOC105557363 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04659//PF00130//PF04611//PF00628//PF03184 Archaeal flagella protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Mating type protein A alpha Y mating type dependent binding region//PHD-finger//DDE superfamily endonuclease GO:0006355//GO:0019953//GO:0035556//GO:0097588 regulation of transcription, DNA-templated//sexual reproduction//intracellular signal transduction//archaeal or bacterial-type flagellum-dependent cell motility GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- -- -- Cluster-8309.48531 BP_3 79.71 9.27 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48532 BP_3 581.21 12.17 2593 -- -- -- -- -- 642924278 XM_008196007.1 103 6.48227e-44 PREDICTED: Tribolium castaneum uncharacterized LOC103313241 (LOC103313241), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF07645//PF00008//PF13895//PF08040 Calcium-binding EGF domain//EGF-like domain//Immunoglobulin domain//MNLL subunit GO:0006118 obsolete electron transport GO:0005509//GO:0005515//GO:0003954 calcium ion binding//protein binding//NADH dehydrogenase activity GO:0005739 mitochondrion -- -- Cluster-8309.48534 BP_3 6.61 1.06 592 642914038 XP_008201518.1 746 1.2e-76 PREDICTED: syntaxin-binding protein 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- K08518 STXBP5 syntaxin-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08518 Q5T5C0 334 2.9e-30 Syntaxin-binding protein 5 OS=Homo sapiens GN=STXBP5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.48535 BP_3 173.00 6.87 1505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48537 BP_3 24.52 0.94 1553 642918172 XP_008191396.1 358 3.1e-31 PREDICTED: uncharacterized protein LOC103312474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQ46 170 8.0e-11 EF-hand calcium-binding domain-containing protein 2 OS=Mus musculus GN=Efcab2 PE=2 SV=1 PF03982//PF03145 Diacylglycerol acyltransferase//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0005634 nucleus -- -- Cluster-8309.48541 BP_3 237.50 1.32 8984 642933690 XP_008197522.1 457 5.9e-42 PREDICTED: golgin subfamily A member 4-like [Tribolium castaneum]>gi|270012607|gb|EFA09055.1| hypothetical protein TcasGA2_TC006768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 227 1.1e-16 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF02179//PF04048 BAG domain//Sec8 exocyst complex component specific domain GO:0006904//GO:0015031 vesicle docking involved in exocytosis//protein transport GO:0051087 chaperone binding GO:0000145 exocyst -- -- Cluster-8309.48542 BP_3 92.15 0.95 4965 546671406 ERL83731.1 3007 0.0e+00 hypothetical protein D910_00944, partial [Dendroctonus ponderosae]>gi|546675549|gb|ERL86722.1| hypothetical protein D910_04128, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24247 1505 4.1e-165 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 PF06529 Vertebrate interleukin-3 regulated transcription factor GO:0007623//GO:0006351 circadian rhythm//transcription, DNA-templated -- -- GO:0005634 nucleus KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.48543 BP_3 25.90 0.38 3593 546673034 ERL84720.1 1157 1.6e-123 hypothetical protein D910_02145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24247 439 1.2e-41 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.48545 BP_3 929.08 9.42 5047 546671406 ERL83731.1 3164 0.0e+00 hypothetical protein D910_00944, partial [Dendroctonus ponderosae]>gi|546675549|gb|ERL86722.1| hypothetical protein D910_04128, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24247 1688 2.5e-186 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 PF06529 Vertebrate interleukin-3 regulated transcription factor GO:0006351//GO:0007623 transcription, DNA-templated//circadian rhythm -- -- GO:0005634 nucleus KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.48546 BP_3 83.35 221.24 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48548 BP_3 17.47 0.31 2972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48550 BP_3 536.01 14.74 2045 751799211 XP_011209556.1 727 6.7e-74 PREDICTED: methyltransferase-like protein 23 [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q5U312 190 5.1e-13 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF00887//PF13606//PF00023//PF16367//PF06839//PF00076//PF06177 Acyl CoA binding protein//Ankyrin repeat//Ankyrin repeat//RNA recognition motif//GRF zinc finger//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//QueT transporter -- -- GO:0008270//GO:0000062//GO:0003676//GO:0005515 zinc ion binding//fatty-acyl-CoA binding//nucleic acid binding//protein binding GO:0005886 plasma membrane -- -- Cluster-8309.48552 BP_3 16.06 3.30 526 642935292 XP_008197953.1 581 1.4e-57 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X4 [Tribolium castaneum]>gi|642935294|ref|XP_008197954.1| PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X4 [Tribolium castaneum]>gi|642935296|ref|XP_008197955.1| PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X4 [Tribolium castaneum] 705662443 XM_010129333.1 45 2.17746e-12 PREDICTED: Chlamydotis macqueenii CAP-GLY domain containing linker protein 1 (CLIP1), mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 304 7.8e-27 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF08702//PF13949//PF05531//PF02185 Fibrinogen alpha/beta chain family//ALIX V-shaped domain binding to HIV//Nucleopolyhedrovirus P10 protein//Hr1 repeat GO:0030168//GO:0051258//GO:0007165 platelet activation//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0005515 receptor binding//protein binding, bridging//protein binding GO:0005577//GO:0019028 fibrinogen complex//viral capsid -- -- Cluster-8309.48553 BP_3 126.12 5.47 1404 189234028 XP_973216.2 1787 5.6e-197 PREDICTED: dual specificity mitogen-activated protein kinase kinase dSOR1 [Tribolium castaneum]>gi|270014747|gb|EFA11195.1| hypothetical protein TcasGA2_TC004803 [Tribolium castaneum] -- -- -- -- -- K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q24324 1479 1.2e-162 Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster GN=Dsor1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0581 Mitogen-activated protein kinase kinase (MAP2K) Cluster-8309.48556 BP_3 13.00 6.20 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48562 BP_3 87.07 0.72 6104 642916731 XP_008192389.1 645 6.4e-64 PREDICTED: uncharacterized protein LOC103312734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48563 BP_3 86.75 0.73 5994 642916731 XP_008192389.1 645 6.3e-64 PREDICTED: uncharacterized protein LOC103312734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48564 BP_3 344.05 1.79 9559 91084029 XP_966465.1 4108 0.0e+00 PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|642924795|ref|XP_008194044.1| PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270006700|gb|EFA03148.1| hypothetical protein TcasGA2_TC013061 [Tribolium castaneum] 440199242 JQ783618.1 203 6.20281e-99 Schreckensteinia sp. Sktn ala-tRNA synthetase mRNA, partial cds K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VLM8 3510 0.0e+00 Alanine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-ala PE=2 SV=1 PF00071//PF01411//PF02272//PF01018//PF00400//PF01399//PF02421//PF00025//PF07973//PF01343//PF01926 Ras family//tRNA synthetases class II (A)//DHHA1 domain//GTP1/OBG//WD domain, G-beta repeat//PCI domain//Ferrous iron transport protein B//ADP-ribosylation factor family//Threonyl and Alanyl tRNA synthetase second additional domain//Peptidase family S49//50S ribosome-binding GTPase GO:0015684//GO:0006508//GO:0006522//GO:0006413//GO:0007264//GO:0043039//GO:0006419//GO:0006446//GO:0006531 ferrous iron transport//proteolysis//alanine metabolic process//translational initiation//small GTPase mediated signal transduction//tRNA aminoacylation//alanyl-tRNA aminoacylation//regulation of translational initiation//aspartate metabolic process GO:0000166//GO:0016876//GO:0008233//GO:0003743//GO:0005524//GO:0003676//GO:0005525//GO:0015093//GO:0005515//GO:0004813 nucleotide binding//ligase activity, forming aminoacyl-tRNA and related compounds//peptidase activity//translation initiation factor activity//ATP binding//nucleic acid binding//GTP binding//ferrous iron transmembrane transporter activity//protein binding//alanine-tRNA ligase activity GO:0005840//GO:0005737//GO:0016021 ribosome//cytoplasm//integral component of membrane KOG0188 Alanyl-tRNA synthetase Cluster-8309.48567 BP_3 419.14 7.45 3004 642927943 XP_008195456.1 2414 2.3e-269 PREDICTED: tetratricopeptide repeat protein 37 [Tribolium castaneum] -- -- -- -- -- K12600 SKI3, TTC37 superkiller protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12600 Q6PGP7 941 6.2e-100 Tetratricopeptide repeat protein 37 OS=Homo sapiens GN=TTC37 PE=1 SV=1 PF13414//PF13174//PF13176//PF13371//PF13181//PF13374//PF00515 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1127 TPR repeat-containing protein Cluster-8309.48571 BP_3 2088.73 140.36 1009 642926280 XP_008194858.1 520 3.3e-50 PREDICTED: uncharacterized protein LOC103313420 isoform X1 [Tribolium castaneum]>gi|270008508|gb|EFA04956.1| hypothetical protein TcasGA2_TC015025 [Tribolium castaneum] 749773866 XM_011143969.1 84 9.0159e-34 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X1, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48572 BP_3 15.54 0.72 1327 270013786 EFA10234.1 357 3.5e-31 hypothetical protein TcasGA2_TC012431 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48573 BP_3 3.66 0.73 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48574 BP_3 135.65 0.99 6868 642930100 XP_008196251.1 1594 6.5e-174 PREDICTED: putative epidermal cell surface receptor isoform X2 [Tribolium castaneum] 195454384 XM_002074181.1 39 6.53796e-08 Drosophila willistoni GK14524 (Dwil\GK14524), mRNA -- -- -- -- Q04164 1071 1.2e-114 Putative epidermal cell surface receptor OS=Drosophila melanogaster GN=sas PE=2 SV=2 PF00041//PF02556//PF16656//PF00093//PF05384 Fibronectin type III domain//Preprotein translocase subunit SecB//Purple acid Phosphatase, N-terminal domain//von Willebrand factor type C domain//Sensor protein DegS GO:0015031//GO:0006771//GO:0019497//GO:0051262//GO:0007165 protein transport//riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein tetramerization//signal transduction GO:0046872//GO:0016301//GO:0003993//GO:0051082//GO:0005515 metal ion binding//kinase activity//acid phosphatase activity//unfolded protein binding//protein binding -- -- -- -- Cluster-8309.48576 BP_3 2.78 0.38 646 270015858 EFA12306.1 324 1.1e-27 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48577 BP_3 164.36 4.23 2164 270015858 EFA12306.1 324 3.8e-27 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48578 BP_3 66.83 1.05 3347 91085761 XP_974130.1 3646 0.0e+00 PREDICTED: sodium/calcium exchanger 3 isoform X1 [Tribolium castaneum]>gi|270010000|gb|EFA06448.1| hypothetical protein TcasGA2_TC009330 [Tribolium castaneum] 768447007 XM_011567171.1 99 1.40358e-41 PREDICTED: Plutella xylostella sodium/calcium exchanger 1-like (LOC105395228), partial mRNA K05849 SLC8A, NCX solute carrier family 8 (sodium/calcium exchanger) http://www.genome.jp/dbget-bin/www_bget?ko:K05849 P70549 2204 2.4e-246 Sodium/calcium exchanger 3 OS=Rattus norvegicus GN=Slc8a3 PE=2 SV=1 PF01699//PF03160 Sodium/calcium exchanger protein//Calx-beta domain GO:0007154//GO:0006816//GO:0055085 cell communication//calcium ion transport//transmembrane transport GO:0005432 calcium:sodium antiporter activity GO:0016021 integral component of membrane KOG1306 Ca2+/Na+ exchanger NCX1 and related proteins Cluster-8309.48579 BP_3 37.00 6.04 587 72016467 XP_782887.1 302 3.6e-25 PREDICTED: ankyrin-1-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 272 4.5e-23 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.4858 BP_3 10.62 0.50 1311 91085541 XP_972533.1 1214 1.4e-130 PREDICTED: nucleoredoxin [Tribolium castaneum]>gi|270008359|gb|EFA04807.1| hypothetical protein TcasGA2_TC014856 [Tribolium castaneum] -- -- -- -- -- K17609 NXN nucleoredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K17609 Q503L9 475 2.9e-46 Nucleoredoxin OS=Danio rerio GN=nxn PE=2 SV=1 PF00832 Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2501 Thioredoxin, nucleoredoxin and related proteins Cluster-8309.48580 BP_3 36.00 4.48 679 170053867 XP_001862871.1 152 1.0e-07 predicted protein [Culex quinquefasciatus]>gi|167874341|gb|EDS37724.1| predicted protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48582 BP_3 93.00 3.30 1651 817061123 XP_012252151.1 475 8.9e-45 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00657//PF00448 GDSL-like Lipase/Acylhydrolase//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0016788 GTP binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.48583 BP_3 529.00 9.66 6216 390362249 XP_001190749.2 698 4.7e-70 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 662 2.9e-67 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00004//PF00448//PF00023//PF13606 ATPase family associated with various cellular activities (AAA)//SRP54-type protein, GTPase domain//Ankyrin repeat//Ankyrin repeat GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005515//GO:0005525//GO:0005524 protein binding//GTP binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.48584 BP_3 29.78 0.48 3292 478251779 ENN72225.1 582 7.0e-57 hypothetical protein YQE_11088, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1Y1 385 2.0e-35 ER membrane protein complex subunit 8/9 homolog OS=Drosophila melanogaster GN=CG3501 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3289 Uncharacterized conserved protein encoded by sequence overlapping the COX4 gene Cluster-8309.48587 BP_3 863.00 10.55 4234 642924505 XP_973263.2 4129 0.0e+00 PREDICTED: importin subunit beta-1 [Tribolium castaneum] -- -- -- -- -- K14293 KPNB1 importin subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14293 P70168 3109 0.0e+00 Importin subunit beta-1 OS=Mus musculus GN=Kpnb1 PE=1 SV=2 PF02985//PF03810//PF00514//PF11698 HEAT repeat//Importin-beta N-terminal domain//Armadillo/beta-catenin-like repeat//V-ATPase subunit H GO:0015991//GO:0006886 ATP hydrolysis coupled proton transport//intracellular protein transport GO:0008536//GO:0005515//GO:0016820 Ran GTPase binding//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain KOG1241 Karyopherin (importin) beta 1 Cluster-8309.48588 BP_3 38.05 3.23 859 768914857 XP_011600993.1 335 8.0e-29 PREDICTED: tubulin alpha-1C chain-like [Takifugu rubripes] 741957615 XM_010814273.1 138 7.31179e-64 PREDICTED: Bos taurus tubulin alpha-3 chain (LOC100295712), transcript variant X6, mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P41383 332 7.3e-30 Tubulin alpha-2/alpha-4 chain OS=Patella vulgata GN=TUB2 PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.48589 BP_3 220.12 9.35 1426 746842810 XP_011051628.1 144 1.9e-06 PREDICTED: neprilysin-11-like [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q22523 138 3.8e-07 Neprilysin-21 OS=Caenorhabditis elegans GN=nep-21 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.48595 BP_3 503.12 21.30 1430 642934319 XP_008198599.1 370 1.2e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48596 BP_3 24.48 0.62 2191 642934319 XP_008198599.1 370 1.8e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48597 BP_3 155.83 5.60 1633 91079782 XP_967732.1 655 1.2e-65 PREDICTED: 39S ribosomal protein L38, mitochondrial [Tribolium castaneum]>gi|270003311|gb|EEZ99758.1| hypothetical protein TcasGA2_TC002530 [Tribolium castaneum] 170048742 XM_001870724.1 54 7.02026e-17 Culex quinquefasciatus mitochondrial ribosomal protein L38, mRNA K17419 MRPL38 large subunit ribosomal protein L38 http://www.genome.jp/dbget-bin/www_bget?ko:K17419 Q3ZBF3 401 1.4e-37 39S ribosomal protein L38, mitochondrial OS=Bos taurus GN=MRPL38 PE=1 SV=2 PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.48598 BP_3 124.01 4.64 1580 91079782 XP_967732.1 1056 3.6e-112 PREDICTED: 39S ribosomal protein L38, mitochondrial [Tribolium castaneum]>gi|270003311|gb|EEZ99758.1| hypothetical protein TcasGA2_TC002530 [Tribolium castaneum] 170048742 XM_001870724.1 53 2.44119e-16 Culex quinquefasciatus mitochondrial ribosomal protein L38, mRNA K17419 MRPL38 large subunit ribosomal protein L38 http://www.genome.jp/dbget-bin/www_bget?ko:K17419 Q3ZBF3 690 4.1e-71 39S ribosomal protein L38, mitochondrial OS=Bos taurus GN=MRPL38 PE=1 SV=2 PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.48600 BP_3 78.88 1.63 2625 642934689 XP_972767.2 2951 0.0e+00 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 D3ZGS3 1477 3.8e-162 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Rattus norvegicus GN=Ocrl PE=1 SV=1 PF16276//PF00620//PF01113 Nucleophosmin C-terminal domain//RhoGAP domain//Dihydrodipicolinate reductase, N-terminus GO:0009089//GO:0007165//GO:0055114//GO:0009085 lysine biosynthetic process via diaminopimelate//signal transduction//oxidation-reduction process//lysine biosynthetic process GO:0008839//GO:0003676 4-hydroxy-tetrahydrodipicolinate reductase//nucleic acid binding -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.48602 BP_3 4.58 0.31 1002 642934689 XP_972767.2 841 2.0e-87 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 D3ZGS3 410 7.7e-39 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Rattus norvegicus GN=Ocrl PE=1 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.48604 BP_3 34.00 1.89 1158 642934689 XP_972767.2 367 2.1e-32 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 Q8K337 141 1.4e-07 Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Mus musculus GN=Inpp5b PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48606 BP_3 546.77 3.42 8000 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 204 1.44225e-99 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF13639//PF01165//PF00637//PF12861//PF00443//PF00569//PF02723//PF12678//PF02148//PF14634//PF00097//PF17122 Ring finger domain//Ribosomal protein S21//Region in Clathrin and VPS//Anaphase-promoting complex subunit 11 RING-H2 finger//Ubiquitin carboxyl-terminal hydrolase//Zinc finger, ZZ type//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger GO:0016567//GO:0016192//GO:0006886//GO:0006412//GO:0042254//GO:0016579 protein ubiquitination//vesicle-mediated transport//intracellular protein transport//translation//ribosome biogenesis//protein deubiquitination GO:0004842//GO:0005515//GO:0036459//GO:0046872//GO:0008270//GO:0003735 ubiquitin-protein transferase activity//protein binding//ubiquitinyl hydrolase activity//metal ion binding//zinc ion binding//structural constituent of ribosome GO:0005680//GO:0005840//GO:0016020 anaphase-promoting complex//ribosome//membrane KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.48610 BP_3 154.00 11.72 925 270013391 EFA09839.1 1338 4.3e-145 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 35 1.42834e-06 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P07207 158 1.2e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF00203 Ribosomal protein S19 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.48612 BP_3 162.00 0.93 8680 478262858 ENN81340.1 3676 0.0e+00 hypothetical protein YQE_02251, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VFB7 1853 3.1e-205 Trafficking protein particle complex subunit 10 OS=Drosophila melanogaster GN=SIDL PE=1 SV=1 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG1931 Putative transmembrane protein Cluster-8309.48613 BP_3 66.67 4.92 945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48616 BP_3 14.00 1.19 857 94468538 ABF18118.1 178 1.3e-10 TIL domain-containing cysteine-rich salivary secreted peptide [Aedes aegypti] -- -- -- -- -- -- -- -- -- P0DM55 131 1.5e-06 Venom peptide SjAPI OS=Scorpiops jendeki PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48618 BP_3 1786.00 21817.32 238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48619 BP_3 318.47 7.28 2400 642923613 XP_008193578.1 1827 2.2e-201 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X2 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.02438e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 1323 2.5e-144 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.4862 BP_3 3.00 3.42 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48623 BP_3 122.43 0.88 7031 91077500 XP_969314.1 3473 0.0e+00 PREDICTED: exocyst complex component 1 [Tribolium castaneum]>gi|270002145|gb|EEZ98592.1| hypothetical protein TcasGA2_TC001107 [Tribolium castaneum] 805812953 XM_012292417.1 89 1.07359e-35 PREDICTED: Megachile rotundata exocyst complex component 1 (LOC100878684), transcript variant X4, mRNA -- -- -- -- Q9VVG4 2093 3.8e-233 Exocyst complex component 1 OS=Drosophila melanogaster GN=sec3 PE=1 SV=2 PF00588//PF07544 SpoU rRNA Methylase family//RNA polymerase II transcription mediator complex subunit 9 GO:0009451//GO:0006357//GO:0006396 RNA modification//regulation of transcription from RNA polymerase II promoter//RNA processing GO:0001104//GO:0003723//GO:0008173 RNA polymerase II transcription cofactor activity//RNA binding//RNA methyltransferase activity GO:0016592 mediator complex KOG2148 Exocyst protein Sec3 Cluster-8309.48626 BP_3 697.18 18.98 2062 270012761 EFA09209.1 2062 1.1e-228 Eph receptor tyrosine kinase [Tribolium castaneum] 642930930 XM_008197924.1 296 2.64589e-151 PREDICTED: Tribolium castaneum ephrin type-A receptor 4-B (LOC658635), transcript variant X2, mRNA K05110 EPHB1, ELK, NET Eph receptor B1 http://www.genome.jp/dbget-bin/www_bget?ko:K05110 P28693 779 2.6e-81 Ephrin type-B receptor 2 OS=Gallus gallus GN=EPHB2 PE=1 SV=3 PF02544//PF01404//PF00041//PF16656 3-oxo-5-alpha-steroid 4-dehydrogenase//Ephrin receptor ligand binding domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006629//GO:0006771//GO:0048013 hexachlorocyclohexane metabolic process//lipid metabolic process//riboflavin metabolic process//ephrin receptor signaling pathway GO:0005515//GO:0003993//GO:0046872//GO:0016627 protein binding//acid phosphatase activity//metal ion binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005737 integral component of membrane//cytoplasm -- -- Cluster-8309.48627 BP_3 125.81 5.56 1383 642929791 XP_008195979.1 859 2.2e-89 PREDICTED: oxysterol-binding protein-related protein 9 isoform X2 [Tribolium castaneum] 755507583 XM_006502619.2 92 4.45023e-38 PREDICTED: Mus musculus oxysterol binding protein-like 9 (Osbpl9), transcript variant X3, mRNA -- -- -- -- Q96SU4 629 4.3e-64 Oxysterol-binding protein-related protein 9 OS=Homo sapiens GN=OSBPL9 PE=1 SV=2 PF06667//PF03510 Phage shock protein B//2C endopeptidase (C24) cysteine protease family GO:0009271//GO:0006508//GO:0006355 phage shock//proteolysis//regulation of transcription, DNA-templated GO:0004197 cysteine-type endopeptidase activity -- -- KOG2210 Oxysterol-binding protein Cluster-8309.48628 BP_3 303.36 7.04 2370 665820747 XP_008559286.1 1602 2.7e-175 PREDICTED: guanine nucleotide-binding protein subunit beta-5 [Microplitis demolitor] 807025222 XM_004523529.2 192 1.98283e-93 PREDICTED: Ceratitis capitata guanine nucleotide-binding protein subunit beta-5 (LOC101456443), mRNA K04539 GNB5 guanine nucleotide-binding protein subunit beta-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04539 Q6PNB6 1309 1.0e-142 Guanine nucleotide-binding protein subunit beta-5 OS=Oryctolagus cuniculus GN=GNB5 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.48629 BP_3 362.81 3.53 5246 642912602 XP_008200928.1 1201 1.9e-128 PREDICTED: poly(A) RNA polymerase gld-2 homolog A-like [Tribolium castaneum]>gi|270002400|gb|EEZ98847.1| hypothetical protein TcasGA2_TC004457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW4 846 1.1e-88 ER membrane protein complex subunit 3 OS=Danio rerio GN=emc3 PE=2 SV=1 PF01956//PF06596//PF01909 Integral membrane protein DUF106//Photosystem II reaction centre X protein (PsbX)//Nucleotidyltransferase domain GO:0015979 photosynthesis GO:0016779 nucleotidyltransferase activity GO:0009523//GO:0016020 photosystem II//membrane KOG3188 Uncharacterized conserved protein Cluster-8309.48633 BP_3 172.05 4.73 2046 270001314 EEZ97761.1 2240 2.4e-249 hect domain and RLD 2-like protein [Tribolium castaneum] 642937613 XM_008200900.1 321 3.32435e-165 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 Q4U2R1 1668 2.1e-184 E3 ubiquitin-protein ligase HERC2 OS=Mus musculus GN=Herc2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.48640 BP_3 62.51 3.05 1280 91089043 XP_969794.1 1019 5.8e-108 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] -- -- -- -- -- K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8K4Q0 554 2.0e-55 Regulatory-associated protein of mTOR OS=Mus musculus GN=Rptor PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.48644 BP_3 2.00 9.44 265 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48649 BP_3 251.33 4.39 3054 642932587 XP_967273.3 1369 3.6e-148 PREDICTED: S-adenosylmethionine decarboxylase proenzyme isoform X2 [Tribolium castaneum]>gi|270011546|gb|EFA07994.1| hypothetical protein TcasGA2_TC005583 [Tribolium castaneum] -- -- -- -- -- K01611 speD, AMD1 S-adenosylmethionine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01611 P91931 873 4.8e-92 S-adenosylmethionine decarboxylase proenzyme OS=Drosophila melanogaster GN=SamDC PE=2 SV=1 PF01536 Adenosylmethionine decarboxylase GO:0006597//GO:0008295//GO:0006560//GO:0006557//GO:0006525 spermine biosynthetic process//spermidine biosynthetic process//proline metabolic process//S-adenosylmethioninamine biosynthetic process//arginine metabolic process GO:0004014 adenosylmethionine decarboxylase activity -- -- KOG0788 S-adenosylmethionine decarboxylase Cluster-8309.4865 BP_3 4.00 1.19 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48653 BP_3 35.00 44.49 318 -- -- -- -- -- 642927790 XM_965363.2 50 2.09644e-15 PREDICTED: Tribolium castaneum nucleolysin TIAR (LOC659024), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48654 BP_3 143.00 2.41 3151 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48655 BP_3 37.09 0.66 3019 91079606 XP_966371.1 1455 3.8e-158 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|642917676|ref|XP_008191323.1| PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270003388|gb|EEZ99835.1| hypothetical protein TcasGA2_TC002616 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 585 1.2e-58 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane KOG1304 Amino acid transporters Cluster-8309.48656 BP_3 77.34 0.48 7979 91079606 XP_966371.1 1460 2.6e-158 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|642917676|ref|XP_008191323.1| PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270003388|gb|EEZ99835.1| hypothetical protein TcasGA2_TC002616 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 585 3.1e-58 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 PF01312//PF16588//PF14659 FlhB HrpN YscU SpaS Family//C2H2 zinc-finger//Phage integrase, N-terminal SAM-like domain GO:0015074//GO:0009306 DNA integration//protein secretion GO:0003677//GO:0003676//GO:0008270 DNA binding//nucleic acid binding//zinc ion binding GO:0016020 membrane KOG1304 Amino acid transporters Cluster-8309.48658 BP_3 59.40 0.90 3465 91080721 XP_975378.1 1530 8.7e-167 PREDICTED: lipase 3 [Tribolium castaneum]>gi|270005867|gb|EFA02315.1| hypothetical protein TcasGA2_TC007981 [Tribolium castaneum] -- -- -- -- -- K10770 ALKBH8 alkylated DNA repair protein alkB homolog 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10770 Q95K79 989 1.9e-105 Alkylated DNA repair protein alkB homolog 8 OS=Macaca fascicularis GN=ALKBH8 PE=2 SV=1 PF08168//PF01738//PF08241//PF01209//PF04083 NUC205 domain//Dienelactone hydrolase family//Methyltransferase domain//ubiE/COQ5 methyltransferase family//Partial alpha/beta-hydrolase lipase region GO:0008152//GO:0016042//GO:0006629 metabolic process//lipid catabolic process//lipid metabolic process GO:0008168//GO:0016788//GO:0016787 methyltransferase activity//hydrolase activity, acting on ester bonds//hydrolase activity GO:0005634 nucleus -- -- Cluster-8309.48659 BP_3 20.56 0.81 1514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48664 BP_3 17.86 0.73 1477 780616929 XP_011698547.1 144 1.9e-06 PREDICTED: zinc finger BED domain-containing protein RICESLEEPER 2-like [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48667 BP_3 70.78 0.76 4765 642927980 XP_008195470.1 951 1.6e-99 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AKG8 300 2.1e-25 Focadhesin OS=Mus musculus GN=Focad PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48675 BP_3 499.01 26.22 1209 478263332 ENN81711.1 185 2.8e-11 hypothetical protein YQE_01916, partial [Dendroctonus ponderosae]>gi|546681318|gb|ERL91432.1| hypothetical protein D910_08762 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48676 BP_3 105.79 9.74 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48678 BP_3 816.55 14.51 3005 642918691 XP_008191539.1 1571 1.3e-171 PREDICTED: protein sprint isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 643 2.2e-65 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.48680 BP_3 446.04 8.71 2760 642926591 XP_008194932.1 1964 3.3e-217 PREDICTED: scavenger receptor class B member 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 538 3.0e-53 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.48681 BP_3 145.86 5.45 1582 642923174 XP_008193640.1 552 1.0e-53 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- K10402 KIF20 kinesin family member 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10402 Q9V877 354 3.8e-32 Kinesin-like protein subito OS=Drosophila melanogaster GN=sub PE=1 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0247 Kinesin-like protein Cluster-8309.48682 BP_3 145.08 7.19 1264 642915518 XP_968660.2 732 1.1e-74 PREDICTED: syntaxin-8 [Tribolium castaneum] -- -- -- -- -- K08501 STX8 syntaxin 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08501 Q3T075 258 4.1e-21 Syntaxin-8 OS=Bos taurus GN=STX8 PE=2 SV=1 PF11744//PF05739//PF06009 Aluminium activated malate transporter//SNARE domain//Laminin Domain II GO:0015743//GO:0007155 malate transport//cell adhesion GO:0005515 protein binding -- -- KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.48685 BP_3 188.27 4.14 2482 642920515 XP_008192382.1 1349 6.0e-146 PREDICTED: TWiK family of potassium channels protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 335 9.5e-30 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF07830//PF00520//PF01007 Protein serine/threonine phosphatase 2C, C-terminal domain//Ion transport protein//Inward rectifier potassium channel GO:0006811//GO:0055085//GO:0006813//GO:0006470 ion transport//transmembrane transport//potassium ion transport//protein dephosphorylation GO:0005216//GO:0000287//GO:0004721//GO:0005242//GO:0030145 ion channel activity//magnesium ion binding//phosphoprotein phosphatase activity//inward rectifier potassium channel activity//manganese ion binding GO:0016020//GO:0008076//GO:0016021 membrane//voltage-gated potassium channel complex//integral component of membrane KOG1418 Tandem pore domain K+ channel Cluster-8309.48686 BP_3 13.66 0.92 1004 270009422 EFA05870.1 306 2.1e-25 hypothetical protein TcasGA2_TC008670 [Tribolium castaneum] -- -- -- -- -- K10904 TIPIN TIMELESS-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K10904 Q0IHI4 216 2.4e-16 TIMELESS-interacting protein OS=Xenopus laevis GN=tipin PE=1 SV=1 PF07962 Replication Fork Protection Component Swi3 GO:0006974//GO:0007049//GO:0048478 cellular response to DNA damage stimulus//cell cycle//replication fork protection -- -- GO:0005634 nucleus KOG3004 Meiotic chromosome segregation protein Cluster-8309.48687 BP_3 12.07 0.34 1983 642928356 XP_008195548.1 966 1.2e-101 PREDICTED: abhydrolase domain-containing protein 4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K13699 ABHD5, CGI-58 abhydrolase domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13699 Q9DBL9 560 6.1e-56 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 OS=Mus musculus GN=Abhd5 PE=1 SV=1 PF16929//PF01764//PF07819//PF02230//PF07859//PF03403 Accessory Sec system GspB-transporter//Lipase (class 3)//PGAP1-like protein//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Platelet-activating factor acetylhydrolase, isoform II GO:0006505//GO:0008152//GO:0006886//GO:0006629//GO:0016042//GO:0015031//GO:0046486 GPI anchor metabolic process//metabolic process//intracellular protein transport//lipid metabolic process//lipid catabolic process//protein transport//glycerolipid metabolic process GO:0016788//GO:0003847//GO:0016787 hydrolase activity, acting on ester bonds//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.48692 BP_3 3.00 0.31 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48695 BP_3 165.78 5.22 1821 546673062 ERL84739.1 984 9.4e-104 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 453 1.4e-43 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF02230//PF10503//PF01764//PF03583 Phospholipase/Carboxylesterase//Esterase PHB depolymerase//Lipase (class 3)//Secretory lipase GO:0046486//GO:0006629//GO:0016042 glycerolipid metabolic process//lipid metabolic process//lipid catabolic process GO:0004806//GO:0016787 triglyceride lipase activity//hydrolase activity GO:0005576 extracellular region KOG1552 Predicted alpha/beta hydrolase Cluster-8309.48696 BP_3 9.00 1.30 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48697 BP_3 129.29 1.13 5818 642937199 XP_008198736.1 4828 0.0e+00 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 5.41945e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1968 9.8e-219 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00787//PF00168//PF00454 PX domain//C2 domain//Phosphatidylinositol 3- and 4-kinase -- -- GO:0016773//GO:0035091//GO:0005515 phosphotransferase activity, alcohol group as acceptor//phosphatidylinositol binding//protein binding -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.487 BP_3 6.00 0.31 1229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4870 BP_3 7.00 4.30 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48701 BP_3 216.67 2.64 4242 642931487 XP_008196606.1 1648 2.2e-180 PREDICTED: insulin receptor substrate 1 isoform X10 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 B4NZ70 563 5.9e-56 Insulin receptor substrate 1 OS=Drosophila yakuba GN=chico PE=3 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.48703 BP_3 1670.36 69.27 1454 270013585 EFA10033.1 947 1.5e-99 hypothetical protein TcasGA2_TC012205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N3F8 294 3.1e-25 MICAL-like protein 1 OS=Homo sapiens GN=MICALL1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48706 BP_3 226.70 7.76 1700 332376807 AEE63543.1 1800 2.1e-198 unknown [Dendroctonus ponderosae] 645003053 XM_008209892.1 41 1.23268e-09 PREDICTED: Nasonia vitripennis kynurenine--oxoglutarate transaminase 3-like (LOC100119206), mRNA K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 1245 2.0e-135 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF00155//PF01053 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.48707 BP_3 418.32 10.23 2263 91088777 XP_967353.1 2052 1.7e-227 PREDICTED: protein phosphatase 1 regulatory subunit 16A [Tribolium castaneum]>gi|270011631|gb|EFA08079.1| hypothetical protein TcasGA2_TC005675 [Tribolium castaneum] -- -- -- -- -- K17458 PPP1R16A, MYPT3 protein phosphatase 1 regulatory subunit 16A http://www.genome.jp/dbget-bin/www_bget?ko:K17458 Q95N27 945 1.6e-100 Protein phosphatase 1 regulatory inhibitor subunit 16B OS=Bos taurus GN=PPP1R16B PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.48708 BP_3 1579.46 5065.66 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48709 BP_3 97617.54 3689.10 1568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48710 BP_3 222.39 10.95 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48715 BP_3 34.11 0.41 4350 91093869 XP_967782.1 6281 0.0e+00 PREDICTED: cytoplasmic FMR1-interacting protein [Tribolium castaneum]>gi|270014526|gb|EFA10974.1| hypothetical protein TcasGA2_TC004140 [Tribolium castaneum] 572271770 XM_006613756.1 995 0 PREDICTED: Apis dorsata cytoplasmic FMR1-interacting protein-like (LOC102675501), mRNA K05749 CYFIP cytoplasmic FMR1 interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05749 Q9VF87 5547 0.0e+00 Cytoplasmic FMR1-interacting protein OS=Drosophila melanogaster GN=Sra-1 PE=1 SV=1 -- -- -- -- -- -- GO:0005737 cytoplasm KOG3534 p53 inducible protein PIR121 Cluster-8309.48716 BP_3 12.00 0.45 1588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48717 BP_3 10.67 0.72 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48718 BP_3 513.59 7.22 3718 189239090 XP_968540.2 1587 2.3e-173 PREDICTED: cystathionine beta-synthase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01697 E4.2.1.22, CBS cystathionine beta-synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01697 P35520 1187 2.3e-128 Cystathionine beta-synthase OS=Homo sapiens GN=CBS PE=1 SV=2 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- KOG1252 Cystathionine beta-synthase and related enzymes Cluster-8309.48723 BP_3 201.16 3.89 2783 91083989 XP_975221.1 158 8.6e-08 PREDICTED: CKLF-like MARVEL transmembrane domain-containing protein 8 [Tribolium castaneum]>gi|270007988|gb|EFA04436.1| hypothetical protein TcasGA2_TC014737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.48724 BP_3 1548.03 21.78 3718 478260883 ENN80520.1 656 2.1e-65 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IZR5 180 1.3e-11 CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Homo sapiens GN=CMTM4 PE=1 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane KOG4788 Members of chemokine-like factor super family and related proteins Cluster-8309.48725 BP_3 187.39 3.49 2881 189241581 XP_969604.2 2443 9.8e-273 PREDICTED: phosphoinositide 3-kinase adapter protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.6e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0016020//GO:0005801 membrane//cis-Golgi network -- -- Cluster-8309.48727 BP_3 252.66 3.78 3514 91090862 XP_972769.1 1643 6.9e-180 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 132 6.6682e-60 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 Q92905 1371 9.9e-150 COP9 signalosome complex subunit 5 OS=Homo sapiens GN=COPS5 PE=1 SV=4 PF11890//PF03083//PF01040//PF01398 Domain of unknown function (DUF3410)//Sugar efflux transporter for intercellular exchange//UbiA prenyltransferase family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0046983//GO:0005515//GO:0004659 protein dimerization activity//protein binding//prenyltransferase activity GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.48728 BP_3 58.20 0.85 3573 91090862 XP_972769.1 1643 7.1e-180 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 132 6.78132e-60 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 O35864 1371 1.0e-149 COP9 signalosome complex subunit 5 OS=Mus musculus GN=Cops5 PE=1 SV=3 PF03083//PF01040//PF01398 Sugar efflux transporter for intercellular exchange//UbiA prenyltransferase family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0004659//GO:0005515 prenyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.48729 BP_3 5.29 0.61 712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4873 BP_3 5.00 0.52 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48731 BP_3 230.16 2.65 4474 478255758 ENN75967.1 1670 6.5e-183 hypothetical protein YQE_07501, partial [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 P57094 335 1.7e-29 Axin-1 OS=Danio rerio GN=axin1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48735 BP_3 375.62 3.16 6014 478260301 ENN80053.1 2656 4.1e-297 hypothetical protein YQE_03529, partial [Dendroctonus ponderosae] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 1477 8.7e-162 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 PF04851//PF04408//PF02562//PF00437//PF07652//PF00270 Type III restriction enzyme, res subunit//Helicase associated domain (HA2)//PhoH-like protein//Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0019079//GO:0006810 viral genome replication//transport GO:0016787//GO:0003677//GO:0004386//GO:0005524//GO:0008026//GO:0003676 hydrolase activity//DNA binding//helicase activity//ATP binding//ATP-dependent helicase activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.48739 BP_3 64.21 3.54 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48740 BP_3 71.28 1.35 2833 189237332 XP_973384.2 1523 4.6e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 9.42901e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.4e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.48741 BP_3 87.61 1.73 2727 189237332 XP_973384.2 1500 2.1e-163 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 9.07167e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.3e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.48743 BP_3 85.97 0.51 8344 642919073 XP_008191722.1 1583 1.5e-172 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 1281 6.4e-139 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.48744 BP_3 57.01 0.59 4987 642929749 XP_008195960.1 2122 2.8e-235 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887//PF05433 Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain -- -- -- -- GO:0016020//GO:0019867 membrane//outer membrane -- -- Cluster-8309.48745 BP_3 103.95 0.68 7638 91091742 XP_966408.1 1143 1.4e-121 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 839 1.1e-87 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF05372//PF02088//PF00202//PF03431//PF02424 Delta lysin family//Ornatin//Aminotransferase class-III//RNA replicase, beta-chain//ApbE family GO:0006144//GO:0008152//GO:0019079//GO:0017013//GO:0030193//GO:0007155//GO:0019836 purine nucleobase metabolic process//metabolic process//viral genome replication//protein flavinylation//regulation of blood coagulation//cell adhesion//hemolysis by symbiont of host erythrocytes GO:0030170//GO:0008483//GO:0003968 pyridoxal phosphate binding//transaminase activity//RNA-directed RNA polymerase activity GO:0031379//GO:0005576 RNA-directed RNA polymerase complex//extracellular region KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.48748 BP_3 58.84 0.78 3923 270016526 EFA12972.1 942 1.5e-98 hypothetical protein TcasGA2_TC010996 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 561 9.3e-56 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF09198 Bacteriophage T4 beta-glucosyltransferase GO:0006304 DNA modification GO:0033821 DNA beta-glucosyltransferase activity -- -- KOG3097 Predicted membrane protein Cluster-8309.4875 BP_3 19.04 2.63 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48751 BP_3 1085.87 14.94 3796 642930270 XP_008196324.1 1192 1.5e-127 PREDICTED: uncharacterized protein LOC103313834 [Tribolium castaneum] 642930269 XM_008198102.1 181 4.15831e-87 PREDICTED: Tribolium castaneum uncharacterized LOC103313834 (LOC103313834), mRNA -- -- -- -- -- -- -- -- PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.48752 BP_3 8.00 1.77 509 546673958 ERL85466.1 195 8.1e-13 hypothetical protein D910_02885 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVH3 123 7.4e-06 MICOS complex subunit MIC13 homolog OS=Drosophila melanogaster GN=CG7603 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48753 BP_3 177.00 14.00 901 546673958 ERL85466.1 303 4.3e-25 hypothetical protein D910_02885 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVH3 166 1.4e-10 MICOS complex subunit MIC13 homolog OS=Drosophila melanogaster GN=CG7603 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48757 BP_3 100.44 1.40 3744 91094203 XP_971608.1 1093 4.4e-116 PREDICTED: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [Tribolium castaneum]>gi|270010912|gb|EFA07360.1| hypothetical protein TcasGA2_TC015960 [Tribolium castaneum] 826492697 XM_012684964.1 53 5.85702e-16 PREDICTED: Monomorium pharaonis probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (LOC105838989), mRNA K03847 ALG12 alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03847 Q9VH78 668 3.5e-68 Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster GN=CG8412 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) Cluster-8309.48759 BP_3 139.00 1.50 4758 270006061 EFA02509.1 152 7.3e-07 hypothetical protein TcasGA2_TC008212 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13748//PF14659 ABC transporter transmembrane region//Phage integrase, N-terminal SAM-like domain GO:0055085//GO:0006810//GO:0015074 transmembrane transport//transport//DNA integration GO:0003677//GO:0005524//GO:0042626 DNA binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.4876 BP_3 31.75 2.19 989 642919293 XP_008191813.1 951 3.4e-100 PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum]>gi|642919295|ref|XP_008191814.1| PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3X5 555 1.2e-55 Transmembrane and TPR repeat-containing protein CG4341 OS=Drosophila melanogaster GN=CG4341 PE=2 SV=1 PF13176//PF13414//PF13371//PF13181//PF13374//PF00515 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.48760 BP_3 51.81 0.94 2962 189237054 XP_966641.2 758 2.4e-77 PREDICTED: bcl-2-related ovarian killer protein [Tribolium castaneum]>gi|270007277|gb|EFA03725.1| hypothetical protein TcasGA2_TC013830 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I8I2 201 3.9e-14 Bcl-2-related ovarian killer protein OS=Gallus gallus GN=BOK PE=2 SV=1 PF00452//PF14489 Apoptosis regulator proteins, Bcl-2 family//QueF-like protein GO:0042981//GO:0008616 regulation of apoptotic process//queuosine biosynthetic process GO:0033739 preQ1 synthase activity -- -- -- -- Cluster-8309.48762 BP_3 158.35 1.54 5251 642934118 XP_008199283.1 1895 6.2e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1299 3.3e-141 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.48765 BP_3 170.57 1.80 4870 478255412 ENN75634.1 2657 2.5e-297 hypothetical protein YQE_07812, partial [Dendroctonus ponderosae] 558207907 XM_006132981.1 93 4.43574e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 1706 2.0e-188 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF08506//PF05743//PF05773 Cse1//UEV domain//RWD domain GO:0006886//GO:0015031//GO:0006464 intracellular protein transport//protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.48766 BP_3 849.29 13.18 3398 642923323 XP_001814851.2 2046 1.2e-226 PREDICTED: transport and Golgi organization protein 6 [Tribolium castaneum]>gi|270007618|gb|EFA04066.1| hypothetical protein TcasGA2_TC014300 [Tribolium castaneum] 501297508 AK417956.1 98 5.12593e-41 Riptortus pedestris mRNA for NEDD8, putative, complete cds, sequence id: Rped-1360 -- -- -- -- P61282 288 3.7e-24 NEDD8 OS=Bos taurus GN=NEDD8 PE=3 SV=1 PF13443//PF00452//PF00240//PF02985//PF14560 Cro/C1-type HTH DNA-binding domain//Apoptosis regulator proteins, Bcl-2 family//Ubiquitin family//HEAT repeat//Ubiquitin-like domain GO:0042981 regulation of apoptotic process GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding -- -- KOG0005 Ubiquitin-like protein Cluster-8309.48767 BP_3 4.21 0.81 541 478260658 ENN80355.1 495 1.4e-47 hypothetical protein YQE_03214, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q25519 430 2.0e-41 Phenoloxidase subunit 2 OS=Manduca sexta GN=ppo PE=1 SV=3 PF03490 Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.48769 BP_3 13.00 1.44 727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4877 BP_3 27.25 1.82 1015 642919293 XP_008191813.1 951 3.5e-100 PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum]>gi|642919295|ref|XP_008191814.1| PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3X5 555 1.2e-55 Transmembrane and TPR repeat-containing protein CG4341 OS=Drosophila melanogaster GN=CG4341 PE=2 SV=1 PF13371//PF13374//PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.48772 BP_3 31.72 0.41 3991 642931092 XP_008196207.1 1720 9.3e-189 PREDICTED: ATP-dependent RNA helicase DDX42 [Tribolium castaneum]>gi|270012072|gb|EFA08520.1| hypothetical protein TcasGA2_TC006173 [Tribolium castaneum] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q5F485 1214 1.8e-131 ATP-dependent RNA helicase DDX42 OS=Gallus gallus GN=DDX42 PE=2 SV=1 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0008026 ATP binding//nucleic acid binding//DNA binding//hydrolase activity//ATP-dependent helicase activity -- -- KOG0334 RNA helicase Cluster-8309.48773 BP_3 164.09 5.38 1763 642912303 XP_008200641.1 1230 2.7e-132 PREDICTED: protein couch potato isoform X3 [Tribolium castaneum] 642912304 XM_008202420.1 321 2.85652e-165 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X4, mRNA -- -- -- -- Q01617 713 9.9e-74 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00076//PF17051 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Cytochrome C oxidase assembly factor 2 GO:0033617 mitochondrial respiratory chain complex IV assembly GO:0003676 nucleic acid binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.48774 BP_3 36.67 0.62 3162 642934087 XP_008196609.1 1036 1.5e-109 PREDICTED: phosphatase and actin regulator 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.4e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF04904//PF00344//PF00957 NAB conserved region 1 (NCD1)//SecY translocase//Synaptobrevin GO:0045892//GO:0016192//GO:0015031 negative regulation of transcription, DNA-templated//vesicle-mediated transport//protein transport -- -- GO:0005634//GO:0016021//GO:0016020 nucleus//integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.48776 BP_3 852.85 17.78 2604 478253945 ENN74237.1 863 1.4e-89 hypothetical protein YQE_09210, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BJM3 303 5.1e-26 Coiled-coil domain-containing protein R3HCC1L OS=Mus musculus GN=R3hcc1l PE=2 SV=1 PF08675 RNA binding domain GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0046872//GO:0003723//GO:0004535 metal ion binding//RNA binding//poly(A)-specific ribonuclease activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG4483 Uncharacterized conserved protein Cluster-8309.48777 BP_3 60.00 8.89 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48778 BP_3 1406.18 14.15 5080 642933029 XP_008197236.1 2620 5.2e-293 PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase 9 isoform X2 [Tribolium castaneum] 642933028 XM_008199014.1 472 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X2, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 2103 1.9e-234 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.4878 BP_3 86.00 1.70 2723 642919293 XP_008191813.1 2123 1.2e-235 PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum]>gi|642919295|ref|XP_008191814.1| PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VQE9 699 6.4e-72 Transmembrane and TPR repeat-containing protein CG31690 OS=Drosophila melanogaster GN=CG31690 PE=2 SV=3 PF13371//PF00515//PF13374//PF13414//PF13176//PF07721//PF13181//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG1124 FOG: TPR repeat Cluster-8309.48781 BP_3 600.58 7.34 4236 91082383 XP_968748.1 3454 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2490 2.1e-279 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF02714//PF00004//PF00664//PF01926//PF13304//PF00931//PF01637//PF06414//PF02367//PF00005//PF03193 Calcium-dependent channel, 7TM region, putative phosphate//ATPase family associated with various cellular activities (AAA)//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//NB-ARC domain//Archaeal ATPase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258 GO:0055085//GO:0006810//GO:0002949 transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626//GO:0017111 ATP binding//ADP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//nucleoside-triphosphatase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.48783 BP_3 3531.47 42.65 4283 642926766 XP_008195005.1 4281 0.0e+00 PREDICTED: copper-transporting ATPase 1 isoform X1 [Tribolium castaneum] 827557043 XM_012694365.1 41 3.14328e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2523 3.2e-283 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF00403//PF01529//PF00122//PF05138 Heavy-metal-associated domain//DHHC palmitoyltransferase//E1-E2 ATPase//Phenylacetic acid catabolic protein GO:0030001//GO:0010124 metal ion transport//phenylacetate catabolic process GO:0000166//GO:0008270//GO:0046872 nucleotide binding//zinc ion binding//metal ion binding -- -- KOG0207 Cation transport ATPase Cluster-8309.48784 BP_3 313.14 9.90 1816 478253376 ENN73730.1 320 9.2e-27 hypothetical protein YQE_09662, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5R7A8 165 3.6e-10 C-Myc-binding protein OS=Pongo abelii GN=MYCBP PE=3 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48786 BP_3 10.07 0.34 1706 665818766 XP_008558228.1 163 1.4e-08 PREDICTED: uncharacterized protein LOC103578820, partial [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48787 BP_3 1418.81 17.41 4220 642924110 XP_008194009.1 2553 2.5e-285 PREDICTED: serine/threonine-protein kinase mig-15 isoform X5 [Tribolium castaneum] 642924109 XM_008195787.1 939 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1466 1.1e-160 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.48790 BP_3 28.36 1.52 1189 642933817 XP_008197388.1 331 3.2e-28 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48792 BP_3 1.00 0.53 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48794 BP_3 1585.77 23.68 3519 478253702 ENN74001.1 1870 3.3e-206 hypothetical protein YQE_09391, partial [Dendroctonus ponderosae] 194741715 XM_001953298.1 46 4.28321e-12 Drosophila ananassae GF17255 (Dana\GF17255), mRNA K01942 HLCS biotin--protein ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01942 Q920N2 610 1.7e-61 Biotin--protein ligase OS=Mus musculus GN=Hlcs PE=2 SV=1 PF02237//PF03099 Biotin protein ligase C terminal domain//Biotin/lipoate A/B protein ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG1536 Biotin holocarboxylase synthetase/biotin-protein ligase Cluster-8309.48795 BP_3 43.53 0.63 3625 546679597 ERL90038.1 1206 3.4e-129 hypothetical protein D910_07396 [Dendroctonus ponderosae] 194741715 XM_001953298.1 46 4.41356e-12 Drosophila ananassae GF17255 (Dana\GF17255), mRNA K01942 HLCS biotin--protein ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01942 Q920N2 484 7.3e-47 Biotin--protein ligase OS=Mus musculus GN=Hlcs PE=2 SV=1 PF03099//PF02237 Biotin/lipoate A/B protein ligase family//Biotin protein ligase C terminal domain GO:0006464 cellular protein modification process -- -- -- -- KOG1536 Biotin holocarboxylase synthetase/biotin-protein ligase Cluster-8309.48796 BP_3 322.10 11.36 1658 642925318 XP_008194505.1 439 1.3e-40 PREDICTED: microtubule-associated proteins 1A/1B light chain 3C-like [Tribolium castaneum]>gi|270008734|gb|EFA05182.1| hypothetical protein TcasGA2_TC015312 [Tribolium castaneum] -- -- -- -- -- K10435 MAP1LC microtubule-associated protein 1 light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10435 Q9BXW4 342 9.8e-31 Microtubule-associated proteins 1A/1B light chain 3C OS=Homo sapiens GN=MAP1LC3C PE=1 SV=1 PF02150//PF04110 RNA polymerases M/15 Kd subunit//Ubiquitin-like autophagy protein Apg12 GO:0000045//GO:0006144//GO:0006351//GO:0006206 autophagosome assembly//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005737 nucleolus//cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-8309.48799 BP_3 6.00 0.51 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48800 BP_3 126.73 0.55 11433 642920053 XP_008192184.1 2013 2.8e-222 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.86778e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.8e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF08112//PF02297//PF13673//PF00159//PF03822//PF08159//PF13508//PF00583//PF08445 ATP synthase epsilon subunit//Cytochrome oxidase c subunit VIb//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide//NAF domain//NUC153 domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein GO:0015986//GO:0015992//GO:0006123//GO:0007165//GO:0006810//GO:0042967 ATP synthesis coupled proton transport//proton transport//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//transport//acyl-carrier-protein biosynthetic process GO:0016747//GO:0004129//GO:0008080//GO:0005179//GO:0042626 transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity//N-acetyltransferase activity//hormone activity//ATPase activity, coupled to transmembrane movement of substances GO:0005576//GO:0005634//GO:0045277//GO:0005739//GO:0033178 extracellular region//nucleus//respiratory chain complex IV//mitochondrion//proton-transporting two-sector ATPase complex, catalytic domain KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.48801 BP_3 3090.82 17.42 8842 91093683 XP_970017.1 1672 7.6e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 2.4e-75 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01395//PF01553//PF04136//PF00115 PBP/GOBP family//Acyltransferase//Sec34-like family//Cytochrome C and Quinol oxidase polypeptide I GO:0008152//GO:0055114//GO:0015992//GO:0006118//GO:0006886//GO:0009060//GO:0006123 metabolic process//oxidation-reduction process//proton transport//obsolete electron transport//intracellular protein transport//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0020037//GO:0009055//GO:0016746//GO:0005506//GO:0005549 cytochrome-c oxidase activity//heme binding//electron carrier activity//transferase activity, transferring acyl groups//iron ion binding//odorant binding GO:0016020//GO:0045277//GO:0005801//GO:0016021 membrane//respiratory chain complex IV//cis-Golgi network//integral component of membrane KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.48802 BP_3 21.01 0.46 2511 759001854 AJP08639.1 1849 6.4e-204 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 436 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1619 1.2e-178 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF06293//PF00069//PF03242//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Late embryogenesis abundant protein//Protein tyrosine kinase GO:0006950//GO:0006468 response to stress//protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.48803 BP_3 10.91 0.79 958 642928025 XP_008200124.1 425 3.3e-39 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q60902 149 1.4e-08 Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus GN=Eps15l1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48804 BP_3 106.01 1.00 5397 91078510 XP_969463.1 3442 0.0e+00 PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|642915541|ref|XP_008190658.1| PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|270003849|gb|EFA00297.1| hypothetical protein TcasGA2_TC003130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82094 856 7.9e-90 TATA element modulatory factor OS=Homo sapiens GN=TMF1 PE=1 SV=2 PF03376 Adenovirus E3B protein -- -- -- -- GO:0016020 membrane KOG4673 Transcription factor TMF, TATA element modulatory factor Cluster-8309.48805 BP_3 12.41 0.51 1456 189236494 XP_001816015.1 658 4.7e-66 PREDICTED: uncharacterized protein LOC100142441 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12337 MRVI1, IRAG inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate http://www.genome.jp/dbget-bin/www_bget?ko:K12337 Q5RHB5 170 7.5e-11 Lymphoid-restricted membrane protein OS=Danio rerio GN=lrmp PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48807 BP_3 32.58 2.98 819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48809 BP_3 64.20 25.72 411 546673559 ERL85134.1 167 1.2e-09 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48813 BP_3 6.00 0.72 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48814 BP_3 91.06 0.97 4808 642910690 XP_008200062.1 1046 1.6e-110 PREDICTED: serine protease snake [Tribolium castaneum]>gi|270015111|gb|EFA11559.1| serine protease P44 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 565 3.9e-56 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF01529//PF12422//PF00089 DHHC palmitoyltransferase//Condensin II non structural maintenance of chromosomes subunit//Trypsin GO:0006508 proteolysis GO:0008236//GO:0004252//GO:0008270 serine-type peptidase activity//serine-type endopeptidase activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.48815 BP_3 254.56 6.25 2255 478263151 ENN81544.1 1606 8.7e-176 hypothetical protein YQE_02073, partial [Dendroctonus ponderosae] -- -- -- -- -- K18166 FOXRED1 FAD-dependent oxidoreductase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18166 Q6DCP1 1055 2.8e-113 FAD-dependent oxidoreductase domain-containing protein 1 OS=Xenopus laevis GN=foxred1 PE=2 SV=1 PF01266//PF03435//PF05834//PF02558//PF00070//PF01494//PF07992//PF02254 FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//Lycopene cyclase protein//Ketopantoate reductase PanE/ApbA//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//TrkA-N domain GO:0015940//GO:0006813//GO:0016117//GO:0055114 pantothenate biosynthetic process//potassium ion transport//carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0071949//GO:0016491//GO:0008677 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oxidoreductase activity//2-dehydropantoate 2-reductase activity -- -- KOG2853 Possible oxidoreductase Cluster-8309.48816 BP_3 13.06 0.58 1385 91086693 XP_969563.1 484 6.8e-46 PREDICTED: 12 kDa FK506-binding protein [Tribolium castaneum]>gi|270010405|gb|EFA06853.1| hypothetical protein TcasGA2_TC009796 [Tribolium castaneum] -- -- -- -- -- K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 P48375 429 6.6e-41 12 kDa FK506-binding protein OS=Drosophila melanogaster GN=FK506-bp2 PE=3 SV=2 PF01581 FMRFamide related peptide family GO:0000413//GO:0006457//GO:0007218 protein peptidyl-prolyl isomerization//protein folding//neuropeptide signaling pathway GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.48817 BP_3 10.94 0.51 1323 642939044 XP_008200198.1 851 1.8e-88 PREDICTED: palmitoyltransferase ZDHHC5 isoform X1 [Tribolium castaneum] 642939045 XM_963847.3 189 5.08869e-92 PREDICTED: Tribolium castaneum palmitoyltransferase ZDHHC5 (LOC657384), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q2THX0 543 3.8e-54 Probable palmitoyltransferase ZDHHC8 OS=Pan troglodytes GN=ZDHHC8 PE=2 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.48822 BP_3 784.79 4.65 8425 642934565 XP_008197717.1 3683 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF06293//PF00069//PF07714//PF01533 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Tospovirus nucleocapsid protein GO:0006468 protein phosphorylation GO:0000166//GO:0005524//GO:0016773//GO:0004672 nucleotide binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020//GO:0019013 membrane//viral nucleocapsid KOG0611 Predicted serine/threonine protein kinase Cluster-8309.48824 BP_3 273.25 4.63 3136 642910907 XP_008193460.1 1000 2.3e-105 PREDICTED: katanin p60 ATPase-containing subunit A-like 1 [Tribolium castaneum]>gi|642910909|ref|XP_008193461.1| PREDICTED: katanin p60 ATPase-containing subunit A-like 1 [Tribolium castaneum] 150013142 CP000743.1 37 3.83928e-07 Methanococcus aeolicus Nankai-3, complete genome K07767 KATNA1 katanin p60 ATPase-containing subunit A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07767 Q9BW62 737 2.9e-76 Katanin p60 ATPase-containing subunit A-like 1 OS=Homo sapiens GN=KATNAL1 PE=1 SV=1 PF01695//PF07728//PF05496//PF01080//PF06068//PF00004//PF03286//PF07726//PF02562//PF02367//PF00910 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Presenilin//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Pox virus Ag35 surface protein//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase GO:0006281//GO:0006310//GO:0002949 DNA repair//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0003723//GO:0005524//GO:0003678//GO:0004190//GO:0003724//GO:0009378//GO:0016887 RNA binding//ATP binding//DNA helicase activity//aspartic-type endopeptidase activity//RNA helicase activity//four-way junction helicase activity//ATPase activity GO:0019031//GO:0005657//GO:0009379//GO:0016021 viral envelope//replication fork//Holliday junction helicase complex//integral component of membrane KOG0738 AAA+-type ATPase Cluster-8309.48826 BP_3 6.00 1.05 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48827 BP_3 70.87 6.30 834 642925847 XP_008190542.1 667 2.5e-67 PREDICTED: mitogen-activated protein kinase-binding protein 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48830 BP_3 68.94 1.65 2309 642921254 XP_008192785.1 1716 1.6e-188 PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|642921256|ref|XP_008192787.1| PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|270006236|gb|EFA02684.1| hypothetical protein TcasGA2_TC008405 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q9VL78 1056 2.2e-113 FK506-binding protein 59 OS=Drosophila melanogaster GN=FKBP59 PE=1 SV=1 PF13371//PF00515//PF04434//PF13176//PF13414//PF00254//PF13181//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//SWIM zinc finger//Tetratricopeptide repeat//TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.48831 BP_3 247.89 1.29 9542 642939376 XP_008193155.1 2929 0.0e+00 PREDICTED: uncharacterized protein LOC660515 isoform X1 [Tribolium castaneum] 642939377 XM_008194938.1 113 6.64564e-49 PREDICTED: Tribolium castaneum hemicentin-1 (LOC660515), transcript variant X2, mRNA -- -- -- -- Q8WZ42 332 8.1e-29 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF05510//PF00895//PF13895//PF06377//PF12422 Sarcoglycan alpha/epsilon//ATP synthase protein 8//Immunoglobulin domain//Adipokinetic hormone//Condensin II non structural maintenance of chromosomes subunit GO:0015986//GO:0015992//GO:0007165 ATP synthesis coupled proton transport//proton transport//signal transduction GO:0015078//GO:0005179//GO:0005515 hydrogen ion transmembrane transporter activity//hormone activity//protein binding GO:0000276//GO:0016012//GO:0005634 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//sarcoglycan complex//nucleus -- -- Cluster-8309.48832 BP_3 105.61 1.05 5146 642929945 XP_008196037.1 334 6.2e-28 PREDICTED: dentin sialophosphoprotein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01734//PF00498 Patatin-like phospholipase//FHA domain GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- -- -- Cluster-8309.48835 BP_3 40.02 0.62 3405 270015833 EFA12281.1 763 7.4e-78 hypothetical protein TcasGA2_TC005266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 289 2.8e-24 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.48836 BP_3 27.00 1.16 1416 641670797 XP_008185349.1 430 1.3e-39 PREDICTED: uncharacterized protein LOC100570268 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07834//PF00665//PF00213 RanGAP1 C-terminal domain//Integrase core domain//ATP synthase delta (OSCP) subunit GO:0015986//GO:0007165//GO:0015074 ATP synthesis coupled proton transport//signal transduction//DNA integration GO:0005096//GO:0046933 GTPase activator activity//proton-transporting ATP synthase activity, rotational mechanism GO:0045259 proton-transporting ATP synthase complex -- -- Cluster-8309.48837 BP_3 274.13 3.49 4073 189241815 XP_971376.2 3970 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1079 8.3e-116 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF00595//PF00397//PF13180 PDZ domain (Also known as DHR or GLGF)//WW domain//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.48841 BP_3 480.33 7.25 3484 642922917 XP_008200451.1 3946 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X2 [Tribolium castaneum] 642922916 XM_008202229.1 385 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5U3A7 2455 2.0e-275 Dynamin-like 120 kDa protein, mitochondrial OS=Danio rerio GN=opa1 PE=2 SV=1 PF02421//PF00071//PF06305//PF01926//PF08477 Ferrous iron transport protein B//Ras family//Protein of unknown function (DUF1049)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0005525//GO:0015093 GTP binding//ferrous iron transmembrane transporter activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.48843 BP_3 3893.61 19.98 9686 642912705 XP_970640.2 7721 0.0e+00 PREDICTED: protein crumbs [Tribolium castaneum] -- -- -- -- -- K16681 CRB protein crumbs http://www.genome.jp/dbget-bin/www_bget?ko:K16681 P10040 4517 0.0e+00 Protein crumbs OS=Drosophila melanogaster GN=crb PE=1 SV=3 PF04053//PF00008//PF11857//PF07645//PF00400 Coatomer WD associated region//EGF-like domain//Domain of unknown function (DUF3377)//Calcium-binding EGF domain//WD domain, G-beta repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515//GO:0004222//GO:0005509 structural molecule activity//protein binding//metalloendopeptidase activity//calcium ion binding GO:0030117 membrane coat -- -- Cluster-8309.48844 BP_3 32.58 0.75 2386 642933337 XP_008197372.1 841 4.7e-87 PREDICTED: E3 ubiquitin-protein ligase SIAH1-like [Tribolium castaneum]>gi|270012581|gb|EFA09029.1| hypothetical protein TcasGA2_TC006740 [Tribolium castaneum] 807039743 XM_004534931.2 43 1.34554e-10 PREDICTED: Ceratitis capitata INO80 complex subunit E (In80e), mRNA K11669 INO80E INO80 complex subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K11669 P61092 293 6.8e-25 E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a PE=1 SV=1 PF03145//PF09726//PF14634//PF00097//PF13639 Seven in absentia protein family//Transmembrane protein//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain GO:0007275//GO:0006511//GO:0044267 multicellular organismal development//ubiquitin-dependent protein catabolic process//cellular protein metabolic process GO:0005515//GO:0008270//GO:0043169//GO:0046872 protein binding//zinc ion binding//cation binding//metal ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG3002 Zn finger protein Cluster-8309.48845 BP_3 114993.39 5712.47 1262 -- -- -- -- -- 572311522 XM_006621426.1 43 7.02243e-11 PREDICTED: Apis dorsata glycine-rich cell wall structural protein 1-like (LOC102675835), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48846 BP_3 464.13 17.67 1558 -- -- -- -- -- 572311522 XM_006621426.1 43 8.71651e-11 PREDICTED: Apis dorsata glycine-rich cell wall structural protein 1-like (LOC102675835), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48847 BP_3 14.75 0.32 2486 91092788 XP_974007.1 441 1.2e-40 PREDICTED: dual specificity protein phosphatase 10 [Tribolium castaneum]>gi|270014786|gb|EFA11234.1| hypothetical protein TcasGA2_TC010766 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q0IID7 252 4.0e-20 Dual specificity protein phosphatase 10 OS=Bos taurus GN=DUSP10 PE=2 SV=1 PF00782 Dual specificity phosphatase, catalytic domain GO:0035335//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0017017//GO:0004725//GO:0008138 MAP kinase tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1716 Dual specificity phosphatase Cluster-8309.48848 BP_3 24.68 0.57 2380 642936612 XP_008198506.1 451 7.8e-42 PREDICTED: uncharacterized protein LOC661523 isoform X2 [Tribolium castaneum]>gi|270013067|gb|EFA09515.1| hypothetical protein TcasGA2_TC011617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48852 BP_3 27.71 1.32 1303 270011080 EFA07528.1 535 7.8e-52 frazzled [Tribolium castaneum] 642929397 XM_008197598.1 54 5.57052e-17 PREDICTED: Tribolium castaneum neogenin (LOC663356), transcript variant X4, mRNA K06765 DCC deleted in colorectal carcinoma http://www.genome.jp/dbget-bin/www_bget?ko:K06765 P43146 202 1.3e-14 Netrin receptor DCC OS=Homo sapiens GN=DCC PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.48853 BP_3 530.94 14.98 2000 642929394 XP_008195818.1 1991 1.8e-220 PREDICTED: neogenin isoform X2 [Tribolium castaneum] 642929397 XM_008197598.1 54 8.63255e-17 PREDICTED: Tribolium castaneum neogenin (LOC663356), transcript variant X4, mRNA K06766 NEO1 neogenin http://www.genome.jp/dbget-bin/www_bget?ko:K06766 Q92859 673 4.9e-69 Neogenin OS=Homo sapiens GN=NEO1 PE=1 SV=2 PF00041//PF13895//PF05790 Fibronectin type III domain//Immunoglobulin domain//Immunoglobulin C2-set domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane KOG4222 Axon guidance receptor Dscam Cluster-8309.48854 BP_3 530.80 5.78 4720 270011080 EFA07528.1 3052 0.0e+00 frazzled [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90610 1088 8.7e-117 Neogenin (Fragment) OS=Gallus gallus PE=2 SV=1 PF06583//PF08465//PF00041//PF16656//PF01108 Neogenin C-terminus//Thymidine kinase from Herpesvirus C-terminal//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Tissue factor GO:0006771//GO:0006206//GO:0006230//GO:0019497 riboflavin metabolic process//pyrimidine nucleobase metabolic process//TMP biosynthetic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0004797//GO:0005524//GO:0005515 acid phosphatase activity//metal ion binding//thymidine kinase activity//ATP binding//protein binding GO:0016021 integral component of membrane KOG4221 Receptor mediating netrin-dependent axon guidance Cluster-8309.48855 BP_3 244.77 1.17 10340 642918328 XP_008199102.1 6476 0.0e+00 PREDICTED: otoferlin-like [Tribolium castaneum] 662203764 XM_008477009.1 153 4.18476e-71 PREDICTED: Diaphorina citri otoferlin-like (LOC103512257), partial mRNA -- -- -- -- Q5SPC5 3900 0.0e+00 Otoferlin OS=Danio rerio GN=otof PE=3 SV=1 PF00168//PF00957//PF08150 C2 domain//Synaptobrevin//FerB (NUC096) domain GO:0016192 vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG1326 Membrane-associated protein FER-1 and related ferlins, contain multiple C2 domains Cluster-8309.48856 BP_3 707.87 3.51 10014 642924895 XP_008194087.1 5496 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P19137 1398 2.1e-152 Laminin subunit alpha-1 OS=Mus musculus GN=Lama1 PE=1 SV=1 PF06008//PF06009 Laminin Domain I//Laminin Domain II GO:0045995//GO:0007165//GO:0030334//GO:0030155//GO:0007155 regulation of embryonic development//signal transduction//regulation of cell migration//regulation of cell adhesion//cell adhesion GO:0005102 receptor binding -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.48857 BP_3 28.00 0.32 4514 642917299 XP_008199241.1 5246 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X2 [Tribolium castaneum] 665815961 XM_008558446.1 642 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3654 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF17096//PF00501 Altered inheritance of mitochondria protein 3//AMP-binding enzyme GO:0008152//GO:0051016 metabolic process//barbed-end actin filament capping GO:0003824 catalytic activity GO:0030479 actin cortical patch KOG3628 Predicted AMP-binding protein Cluster-8309.48858 BP_3 8.81 0.49 1160 478255341 ENN75567.1 1093 1.4e-116 hypothetical protein YQE_07910, partial [Dendroctonus ponderosae] 642917306 XM_008201023.1 73 1.35484e-27 PREDICTED: Tribolium castaneum disco-interacting protein 2 (LOC657292), transcript variant X6, mRNA -- -- -- -- Q14689 845 3.2e-89 Disco-interacting protein 2 homolog A OS=Homo sapiens GN=DIP2A PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG3628 Predicted AMP-binding protein Cluster-8309.4886 BP_3 1.00 0.77 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48860 BP_3 4.00 0.45 718 646719063 KDR21309.1 608 1.5e-60 Reversion-inducing cysteine-rich protein with Kazal motifs, partial [Zootermopsis nevadensis] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 488 5.0e-48 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48863 BP_3 1095.09 9.63 5774 642931136 XP_967600.2 3863 0.0e+00 PREDICTED: DNA-directed RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270012086|gb|EFA08534.1| hypothetical protein TcasGA2_TC006188 [Tribolium castaneum] -- -- -- -- -- K10908 POLRMT, RPO41 DNA-directed RNA polymerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K10908 Q8BKF1 1977 8.8e-220 DNA-directed RNA polymerase, mitochondrial OS=Mus musculus GN=Polrmt PE=2 SV=1 PF03840//PF00940 Preprotein translocase SecG subunit//DNA-dependent RNA polymerase GO:0006144//GO:0009306//GO:0006351//GO:0015031//GO:0006206 purine nucleobase metabolic process//protein secretion//transcription, DNA-templated//protein transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0016740//GO:0015450 DNA-directed RNA polymerase activity//DNA binding//transferase activity//P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0009941//GO:0016021//GO:0005730 chloroplast envelope//integral component of membrane//nucleolus KOG1038 Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation Cluster-8309.48864 BP_3 87.00 14.06 590 795009668 XP_011863002.1 262 1.6e-20 PREDICTED: uncharacterized protein LOC105559376 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00126//PF01047//PF01498//PF09339//PF00165 Bacterial regulatory helix-turn-helix protein, lysR family//MarR family//Transposase//IclR helix-turn-helix domain//Bacterial regulatory helix-turn-helix proteins, AraC family GO:0006355//GO:0015074//GO:0006313 regulation of transcription, DNA-templated//DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.48865 BP_3 429.61 4.17 5253 642914939 XP_008190450.1 1842 8.7e-203 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K13983 MOV10L1 putative helicase MOV10L1 http://www.genome.jp/dbget-bin/www_bget?ko:K13983 Q1LXK4 952 5.7e-101 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF00270//PF05970//PF13361//PF00580//PF00176//PF01637//PF02562//PF04851//PF00437//PF00004 DEAD/DEAH box helicase//PIF1-like helicase//UvrD-like helicase C-terminal domain//UvrD/REP helicase N-terminal domain//SNF2 family N-terminal domain//Archaeal ATPase//PhoH-like protein//Type III restriction enzyme, res subunit//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0006810//GO:0006281//GO:0000723 transport//DNA repair//telomere maintenance GO:0016787//GO:0003677//GO:0005524//GO:0003678//GO:0003676 hydrolase activity//DNA binding//ATP binding//DNA helicase activity//nucleic acid binding GO:0005657 replication fork KOG1804 RNA helicase Cluster-8309.48866 BP_3 153.66 2.20 3656 642914939 XP_008190450.1 1593 4.5e-174 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q1LXK4 922 1.2e-97 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF04851//PF01637//PF02562//PF00176//PF00580//PF00005//PF13361//PF05970//PF00270//PF00004//PF00437 Type III restriction enzyme, res subunit//Archaeal ATPase//PhoH-like protein//SNF2 family N-terminal domain//UvrD/REP helicase N-terminal domain//ABC transporter//UvrD-like helicase C-terminal domain//PIF1-like helicase//DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006281//GO:0006810//GO:0000723 DNA repair//transport//telomere maintenance GO:0003677//GO:0016787//GO:0003678//GO:0005524//GO:0016887//GO:0003676 DNA binding//hydrolase activity//DNA helicase activity//ATP binding//ATPase activity//nucleic acid binding GO:0005657 replication fork KOG1804 RNA helicase Cluster-8309.48867 BP_3 123.96 1.61 3996 270003759 EFA00207.1 1136 4.9e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.76753e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.48868 BP_3 96.69 1.41 3587 642917674 XP_008193576.1 1250 2.6e-134 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 4-like [Tribolium castaneum] -- -- -- -- -- K15426 PPP4R4 serine/threonine-protein phosphatase 4 regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15426 Q6NUP7 745 3.9e-77 Serine/threonine-protein phosphatase 4 regulatory subunit 4 OS=Homo sapiens GN=PPP4R4 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48871 BP_3 292.36 2.30 6415 642937185 XP_008198729.1 2693 2.2e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 3.44727e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.1e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF05192//PF11744//PF00995//PF00023//PF13606 MutS domain III//Aluminium activated malate transporter//Sec1 family//Ankyrin repeat//Ankyrin repeat GO:0006298//GO:0016192//GO:0015743//GO:0006904 mismatch repair//vesicle-mediated transport//malate transport//vesicle docking involved in exocytosis GO:0030983//GO:0005524//GO:0005515 mismatched DNA binding//ATP binding//protein binding -- -- KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.48881 BP_3 225.85 7.17 1811 91085253 XP_973335.1 609 2.8e-60 PREDICTED: uncharacterized protein LOC662125 [Tribolium castaneum]>gi|270009097|gb|EFA05545.1| hypothetical protein TcasGA2_TC015733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00274 Fructose-bisphosphate aldolase class-I GO:0006096//GO:0006098//GO:0006020//GO:0006094//GO:0015976//GO:0006000//GO:0006013 glycolytic process//pentose-phosphate shunt//inositol metabolic process//gluconeogenesis//carbon utilization//fructose metabolic process//mannose metabolic process GO:0004332 fructose-bisphosphate aldolase activity -- -- -- -- Cluster-8309.48882 BP_3 120.03 0.64 9326 546681221 ERL91356.1 1694 2.2e-185 hypothetical protein D910_08688 [Dendroctonus ponderosae] 642927571 XM_008197097.1 82 1.11009e-31 PREDICTED: Tribolium castaneum cAMP-dependent protein kinase type II regulatory subunit (LOC661163), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P81900 1231 4.5e-133 cAMP-dependent protein kinase type II regulatory subunit OS=Drosophila melanogaster GN=Pka-R2 PE=1 SV=2 PF00701//PF15494 Dihydrodipicolinate synthetase family//Scavenger receptor cysteine-rich domain GO:0008152 metabolic process GO:0016829 lyase activity GO:0016020 membrane KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.48883 BP_3 599.66 3.20 9312 546681221 ERL91356.1 1694 2.2e-185 hypothetical protein D910_08688 [Dendroctonus ponderosae] 642927571 XM_008197097.1 82 1.10842e-31 PREDICTED: Tribolium castaneum cAMP-dependent protein kinase type II regulatory subunit (LOC661163), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P81900 1231 4.5e-133 cAMP-dependent protein kinase type II regulatory subunit OS=Drosophila melanogaster GN=Pka-R2 PE=1 SV=2 PF00701//PF15494 Dihydrodipicolinate synthetase family//Scavenger receptor cysteine-rich domain GO:0008152 metabolic process GO:0016829 lyase activity GO:0016020 membrane KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.48884 BP_3 336.18 4.49 3897 332375210 AEE62746.1 1041 4.9e-110 unknown [Dendroctonus ponderosae]>gi|478254335|gb|ENN74587.1| hypothetical protein YQE_08710, partial [Dendroctonus ponderosae]>gi|546674053|gb|ERL85541.1| hypothetical protein D910_02960 [Dendroctonus ponderosae] -- -- -- -- -- K02895 RP-L24, MRPL24, rplX large subunit ribosomal protein L24 http://www.genome.jp/dbget-bin/www_bget?ko:K02895 Q29MA5 828 1.0e-86 Probable 39S ribosomal protein L24, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL24 PE=3 SV=1 PF13482 RNase_H superfamily -- -- GO:0003676 nucleic acid binding -- -- KOG3801 Uncharacterized conserved protein BCN92 Cluster-8309.48887 BP_3 3.00 1.18 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48888 BP_3 12.00 0.35 1951 546682247 ERL92208.1 244 6.4e-18 hypothetical protein D910_09528, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08573//PF07578//PF03122 DNA repair protein endonuclease SAE2/CtIP C-terminus//Lipid A Biosynthesis N-terminal domain//Herpes virus major capsid protein GO:0009245//GO:0006281//GO:0000077//GO:0006308 lipid A biosynthetic process//DNA repair//DNA damage checkpoint//DNA catabolic process GO:0005198//GO:0008915//GO:0000014 structural molecule activity//lipid-A-disaccharide synthase activity//single-stranded DNA endodeoxyribonuclease activity GO:0019028 viral capsid -- -- Cluster-8309.48893 BP_3 16.05 0.33 2658 642925975 XP_967431.2 237 5.7e-17 PREDICTED: uncharacterized protein LOC655776 [Tribolium castaneum] -- -- -- -- -- K17558 PPP1R15B, CREP protein phosphatase 1 regulatory subunit 15B http://www.genome.jp/dbget-bin/www_bget?ko:K17558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48894 BP_3 102.47 0.97 5393 270002310 EEZ98757.1 2340 1.6e-260 hypothetical protein TcasGA2_TC001321 [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 O43795 1233 1.5e-133 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF06414//PF00063//PF00612//PF09293//PF06017//PF00437 Zeta toxin//Myosin head (motor domain)//IQ calmodulin-binding motif//T4 RNase H, C terminal//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0005515//GO:0003677//GO:0003824//GO:0005524//GO:0003774//GO:0016301 protein binding//DNA binding//catalytic activity//ATP binding//motor activity//kinase activity GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.48895 BP_3 94.81 0.98 4940 642930492 XP_008196426.1 2252 2.4e-250 PREDICTED: CLIP-associating protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 867 3.9e-91 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF01528//PF02985 Herpesvirus glycoprotein M//HEAT repeat -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.48897 BP_3 208.00 2.40 4472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01810 LysE type translocator GO:0006865 amino acid transport -- -- GO:0016020 membrane -- -- Cluster-8309.48899 BP_3 1181.95 33.41 1997 546673691 ERL85252.1 2493 1.1e-278 hypothetical protein D910_02673 [Dendroctonus ponderosae] 826416467 XM_012667541.1 210 1.64268e-103 PREDICTED: Monomorium pharaonis asparagine--tRNA ligase, cytoplasmic (LOC105828947), mRNA K01893 NARS, asnS asparaginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01893 Q2KJG3 2079 4.5e-232 Asparagine--tRNA ligase, cytoplasmic OS=Bos taurus GN=NARS PE=2 SV=3 PF00152//PF01409//PF00237//PF01336 tRNA synthetases class II (D, K and N)//tRNA synthetases class II core domain (F)//Ribosomal protein L22p/L17e//OB-fold nucleic acid binding domain GO:0043039//GO:0042254//GO:0006418//GO:0006412 tRNA aminoacylation//ribosome biogenesis//tRNA aminoacylation for protein translation//translation GO:0004812//GO:0003676//GO:0003735//GO:0000166//GO:0000049//GO:0005524 aminoacyl-tRNA ligase activity//nucleic acid binding//structural constituent of ribosome//nucleotide binding//tRNA binding//ATP binding GO:0005737//GO:0005840 cytoplasm//ribosome KOG0555 Asparaginyl-tRNA synthetase Cluster-8309.48901 BP_3 383.73 29.77 913 91087039 XP_974482.1 911 1.4e-95 PREDICTED: AP-3 complex subunit sigma-2 isoform X1 [Tribolium castaneum]>gi|270009628|gb|EFA06076.1| hypothetical protein TcasGA2_TC008912 [Tribolium castaneum] 505849574 XM_004618186.1 123 1.69829e-55 PREDICTED: Sorex araneus adaptor-related protein complex 3, sigma 1 subunit (AP3S1), mRNA K12399 AP3S AP-3 complex subunit sigma http://www.genome.jp/dbget-bin/www_bget?ko:K12399 Q1JQA3 730 5.5e-76 AP-3 complex subunit sigma-2 OS=Bos taurus GN=AP3S2 PE=2 SV=1 -- -- GO:0016192//GO:0015031//GO:0006886 vesicle-mediated transport//protein transport//intracellular protein transport GO:0008565 protein transporter activity GO:0030117 membrane coat KOG0936 Clathrin adaptor complex, small subunit Cluster-8309.48902 BP_3 1844.00 16.62 5639 642919889 XP_008192111.1 3942 0.0e+00 PREDICTED: transmembrane and TPR repeat-containing protein CG4050-like [Tribolium castaneum]>gi|270005381|gb|EFA01829.1| hypothetical protein TcasGA2_TC007431 [Tribolium castaneum] 642919888 XM_008193889.1 143 8.24581e-66 PREDICTED: Tribolium castaneum transmembrane and TPR repeat-containing protein CG4050-like (LOC663014), mRNA -- -- -- -- Q7K4B6 2515 3.5e-282 Transmembrane and TPR repeat-containing protein CG4050 OS=Drosophila melanogaster GN=CG4050 PE=2 SV=1 PF13176//PF13414//PF13371//PF00515//PF13374//PF00619//PF13174//PF10579//PF04977//PF13181//PF08631 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Caspase recruitment domain//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Septum formation initiator//Tetratricopeptide repeat//Meiosis protein SPO22/ZIP4 like GO:0042981//GO:0007268//GO:0051321//GO:0007049 regulation of apoptotic process//synaptic transmission//meiotic cell cycle//cell cycle GO:0033130//GO:0005515//GO:0043495 acetylcholine receptor binding//protein binding//protein anchor -- -- KOG1124 FOG: TPR repeat Cluster-8309.48905 BP_3 1903.14 30.85 3265 91095167 XP_968412.1 623 1.2e-61 PREDICTED: PRA1 family protein 3 [Tribolium castaneum]>gi|270015793|gb|EFA12241.1| hypothetical protein TcasGA2_TC016173 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5J9 362 9.2e-33 PRA1 family protein 3 OS=Mus musculus GN=Arl6ip5 PE=1 SV=2 PF04382//PF02313 SAB domain//Fumarate reductase subunit D GO:0006106//GO:0030866 fumarate metabolic process//cortical actin cytoskeleton organization GO:0008092 cytoskeletal protein binding GO:0005856//GO:0016020 cytoskeleton//membrane KOG4050 Glutamate transporter EAAC1-interacting protein GTRAP3-18 Cluster-8309.48906 BP_3 8.47 3.03 426 546685092 ERL94619.1 231 4.5e-17 hypothetical protein D910_11896 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5F433 148 7.8e-09 PRA1 family protein 3 OS=Gallus gallus GN=ARL6IP5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4050 Glutamate transporter EAAC1-interacting protein GTRAP3-18 Cluster-8309.48909 BP_3 968.14 27.33 1999 91083715 XP_970185.1 1499 2.0e-163 PREDICTED: RNA-binding protein 45 [Tribolium castaneum]>gi|270007883|gb|EFA04331.1| hypothetical protein TcasGA2_TC014625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUH3 745 2.2e-77 RNA-binding protein 45 OS=Homo sapiens GN=RBM45 PE=1 SV=1 PF08777//PF16367//PF00076//PF08675 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0097159//GO:1901363//GO:0004535//GO:0003676//GO:0046872 RNA binding//organic cyclic compound binding//heterocyclic compound binding//poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.48914 BP_3 25.96 0.54 2617 478257801 ENN77944.1 1973 2.8e-218 hypothetical protein YQE_05621, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96MC2 753 3.4e-78 Dynein regulatory complex protein 1 OS=Homo sapiens GN=DRC1 PE=2 SV=2 PF04513//PF02742//PF01972 Baculovirus polyhedron envelope protein, PEP, C terminus//Iron dependent repressor, metal binding and dimerisation domain//Serine dehydrogenase proteinase -- -- GO:0046914//GO:0046983//GO:0005198 transition metal ion binding//protein dimerization activity//structural molecule activity GO:0019028//GO:0016021//GO:0019031 viral capsid//integral component of membrane//viral envelope -- -- Cluster-8309.48917 BP_3 6.74 1.37 528 478253952 ENN74244.1 431 3.6e-40 hypothetical protein YQE_09216, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48920 BP_3 90.20 5.50 1082 91081585 XP_975324.1 389 5.5e-35 PREDICTED: protein FAM177A1 [Tribolium castaneum]>gi|270005105|gb|EFA01553.1| hypothetical protein TcasGA2_TC007114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QLZ5 227 1.4e-17 Protein FAM177A1 OS=Bos taurus GN=FAM177A1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48921 BP_3 78.73 3.23 1466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48925 BP_3 65.30 0.31 10427 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.6e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF05430//PF02891//PF00397//PF00168//PF00632//PF01155 S-adenosyl-L-methionine-dependent methyltransferase//MIZ/SP-RING zinc finger//WW domain//C2 domain//HECT-domain (ubiquitin-transferase)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0016567//GO:0055114 cellular protein modification process//protein ubiquitination//oxidation-reduction process GO:0005515//GO:0016151//GO:0004842//GO:0008270//GO:0016645 protein binding//nickel cation binding//ubiquitin-protein transferase activity//zinc ion binding//oxidoreductase activity, acting on the CH-NH group of donors GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.48926 BP_3 158.38 1.40 5762 642920448 XP_008192355.1 2534 5.5e-283 PREDICTED: nuclear factor related to kappa-B-binding protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K11671 NFRKB, INO80G nuclear factor related to kappa-B-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11671 Q6PIJ4 679 2.8e-69 Nuclear factor related to kappa-B-binding protein OS=Mus musculus GN=Nfrkb PE=2 SV=1 PF10597//PF00397 U5-snRNA binding site 2 of PrP8//WW domain -- -- GO:0030623//GO:0005515 U5 snRNA binding//protein binding -- -- KOG1927 R-kappa-B and related transcription factors Cluster-8309.48927 BP_3 430.71 4.04 5435 642920450 XP_975645.2 2534 5.2e-283 PREDICTED: nuclear factor related to kappa-B-binding protein isoform X2 [Tribolium castaneum]>gi|270005227|gb|EFA01675.1| hypothetical protein TcasGA2_TC007248 [Tribolium castaneum] -- -- -- -- -- K11671 NFRKB, INO80G nuclear factor related to kappa-B-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11671 Q6P4R8 679 2.7e-69 Nuclear factor related to kappa-B-binding protein OS=Homo sapiens GN=NFRKB PE=1 SV=2 PF00397//PF10597 WW domain//U5-snRNA binding site 2 of PrP8 -- -- GO:0030623//GO:0005515 U5 snRNA binding//protein binding -- -- KOG1927 R-kappa-B and related transcription factors Cluster-8309.48929 BP_3 2.00 0.88 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4893 BP_3 58.77 0.96 3255 646703682 KDR12235.1 1809 3.6e-199 Armadillo repeat-containing protein 4 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q5T2S8 1418 3.3e-155 Armadillo repeat-containing protein 4 OS=Homo sapiens GN=ARMC4 PE=1 SV=1 PF02985//PF03739//PF10508//PF11698//PF00514//PF01602 HEAT repeat//Predicted permease YjgP/YjgQ family//Proteasome non-ATPase 26S subunit//V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region GO:0016192//GO:0006886//GO:0015991//GO:0043248 vesicle-mediated transport//intracellular protein transport//ATP hydrolysis coupled proton transport//proteasome assembly GO:0005515//GO:0016820 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221//GO:0016021//GO:0030117 vacuolar proton-transporting V-type ATPase, V1 domain//integral component of membrane//membrane coat KOG0167 FOG: Armadillo/beta-catenin-like repeats Cluster-8309.48932 BP_3 125.21 3.32 2109 91079134 XP_975446.1 995 5.7e-105 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|642916464|ref|XP_008191038.1| PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270004224|gb|EFA00672.1| hypothetical protein TcasGA2_TC003549 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q58DT4 515 1.1e-50 Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Bos taurus GN=PYCR1 PE=2 SV=1 PF03446//PF01408 NAD binding domain of 6-phosphogluconate dehydrogenase//Oxidoreductase family, NAD-binding Rossmann fold GO:0019521//GO:0055114//GO:0006098//GO:0055129//GO:0006525//GO:0006561 D-gluconate metabolic process//oxidation-reduction process//pentose-phosphate shunt//L-proline biosynthetic process//arginine metabolic process//proline biosynthetic process GO:0004616//GO:0000166//GO:0004735//GO:0016491 phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding//pyrroline-5-carboxylate reductase activity//oxidoreductase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.48934 BP_3 5.90 0.42 968 642928567 XP_008199961.1 505 1.7e-48 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 391 1.2e-36 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.48937 BP_3 83.22 5.67 999 478249796 ENN70303.1 1216 6.4e-131 hypothetical protein YQE_12814, partial [Dendroctonus ponderosae] -- -- -- -- -- K04403 MAP3K7IP1, TAB1 TAK1-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04403 Q15750 645 4.3e-66 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens GN=TAB1 PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.4894 BP_3 3.00 0.33 725 795269411 XP_011749182.1 537 2.5e-52 PREDICTED: transcription factor jun-D [Macaca nemestrina] 558695422 NM_005354.5 575 0 Homo sapiens jun D proto-oncogene (JUND), transcript variant 1, mRNA >gnl|BL_ORD_ID|16764092 Homo sapiens jun D proto-oncogene (JUND), transcript variant 1, mRNA K04449 JUND transcription factor jun-D http://www.genome.jp/dbget-bin/www_bget?ko:K04449 A7YY54 537 1.0e-53 Transcription factor jun-D OS=Bos taurus GN=JUND PE=2 SV=1 PF06005//PF08702//PF00170//PF07716//PF03131//PF01166//PF04977 Protein of unknown function (DUF904)//Fibrinogen alpha/beta chain family//bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor//TSC-22/dip/bun family//Septum formation initiator GO:0030168//GO:0000917//GO:0043093//GO:0007165//GO:0051258//GO:0006355//GO:0007049 platelet activation//barrier septum assembly//FtsZ-dependent cytokinesis//signal transduction//protein polymerization//regulation of transcription, DNA-templated//cell cycle GO:0003677//GO:0030674//GO:0043565//GO:0005102//GO:0003700 DNA binding//protein binding, bridging//sequence-specific DNA binding//receptor binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005737//GO:0005577 nucleus//transcription factor complex//cytoplasm//fibrinogen complex KOG0837 Transcriptional activator of the JUN family Cluster-8309.48941 BP_3 551.00 8.06 3587 91080401 XP_966987.1 1815 8.1e-200 PREDICTED: ankyrin repeat and LEM domain-containing protein 2 [Tribolium castaneum]>gi|270005746|gb|EFA02194.1| hypothetical protein TcasGA2_TC007850 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TP65 753 4.6e-78 Ankyrin repeat and LEM domain-containing protein 2 OS=Rattus norvegicus GN=Ankle2 PE=2 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48942 BP_3 48.89 4.10 866 751237885 XP_011172858.1 248 9.8e-19 PREDICTED: uncharacterized protein LOC105205238 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48946 BP_3 1660.00 15.55 5436 189237182 XP_001808720.1 2170 8.4e-241 PREDICTED: FERM, RhoGEF and pleckstrin domain-containing protein 2-like [Tribolium castaneum] 642922446 XM_008194952.1 244 5.6835e-122 PREDICTED: Tribolium castaneum titin-like (LOC655359), mRNA K06082 FARP2, FRG FERM, RhoGEF and pleckstrin domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06082 Q91VS8 1096 1.2e-117 FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Mus musculus GN=Farp2 PE=1 SV=2 PF00621//PF08172 RhoGEF domain//CASP C terminal GO:0043087//GO:0035023//GO:0006891 regulation of GTPase activity//regulation of Rho protein signal transduction//intra-Golgi vesicle-mediated transport GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0030173 integral component of Golgi membrane KOG3531 Rho guanine nucleotide exchange factor CDEP Cluster-8309.48948 BP_3 412.23 10.09 2260 189236990 XP_970274.2 792 2.1e-81 PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|642921800|ref|XP_008199324.1| PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|270008114|gb|EFA04562.1| hypothetical protein TcasGA2_TC010947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZS10 145 9.3e-08 C-type lectin domain family 17, member A OS=Homo sapiens GN=CLEC17A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48949 BP_3 540.86 13.37 2242 270005270 EFA01718.1 1895 2.7e-209 hypothetical protein TcasGA2_TC007298 [Tribolium castaneum] 642920293 XM_008194065.1 444 0 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 9-like (LOC664510), transcript variant X2, mRNA K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 Q3U1V8 1312 4.4e-143 Mitogen-activated protein kinase kinase kinase 9 OS=Mus musculus GN=Map3k9 PE=2 SV=2 PF07714//PF00018//PF14604//PF00069 Protein tyrosine kinase//SH3 domain//Variant SH3 domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- -- -- Cluster-8309.48950 BP_3 437.17 8.42 2795 478258781 ENN78804.1 2058 4.2e-228 hypothetical protein YQE_04741, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZIL9 960 3.6e-102 KIF1-binding protein homolog OS=Gallus gallus GN=kbp PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48951 BP_3 1.00 1.06 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48952 BP_3 19.74 0.36 2913 665817013 XP_008557255.1 179 3.3e-10 PREDICTED: uncharacterized protein LOC103578083 isoform X1 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48954 BP_3 32.84 9.22 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03492 SAM dependent carboxyl methyltransferase -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.48956 BP_3 628.04 9.25 3563 270015294 EFA11742.1 680 3.3e-68 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.48958 BP_3 1520.13 17.19 4553 123463203 XP_001316939.1 238 7.5e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121899660|gb|EAY04716.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 222 2.2e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF04083//PF09174 Partial alpha/beta-hydrolase lipase region//Maf1 regulator GO:0016480//GO:0006629 negative regulation of transcription from RNA polymerase III promoter//lipid metabolic process -- -- -- -- KOG4177 Ankyrin Cluster-8309.48959 BP_3 165.16 47.77 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03492 SAM dependent carboxyl methyltransferase -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.48960 BP_3 1671.14 27.18 3255 270015294 EFA11742.1 680 3.0e-68 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06363 Picornaviridae P3A protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.48962 BP_3 280.00 5.77 2632 546674012 ERL85505.1 2670 4.3e-299 hypothetical protein D910_02924 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q16ZN9 1594 1.0e-175 Conserved oligomeric Golgi complex subunit 3 OS=Aedes aegypti GN=Cog3 PE=3 SV=1 PF04048//PF04136 Sec8 exocyst complex component specific domain//Sec34-like family GO:0015031//GO:0006886//GO:0006904 protein transport//intracellular protein transport//vesicle docking involved in exocytosis -- -- GO:0016020//GO:0000145//GO:0005801 membrane//exocyst//cis-Golgi network KOG2604 Subunit of cis-Golgi transport vesicle tethering complex - Sec34p Cluster-8309.48963 BP_3 20.13 0.35 3092 189235061 XP_001814285.1 1167 9.6e-125 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51523 313 4.2e-27 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.48969 BP_3 298.00 7.83 2125 91092900 XP_970994.1 993 9.9e-105 PREDICTED: WW domain-binding protein 11 [Tribolium castaneum]>gi|270003035|gb|EEZ99482.1| hypothetical protein TcasGA2_TC000057 [Tribolium castaneum] 346710668 AK382553.1 92 6.89984e-38 Bombyx mori mRNA, clone: fdpe20P17 K12866 WBP11, NPWBP WW domain-binding protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12866 Q9Y2W2 452 2.2e-43 WW domain-binding protein 11 OS=Homo sapiens GN=WBP11 PE=1 SV=1 PF09429 WW domain binding protein 11 GO:0006396 RNA processing -- -- -- -- KOG4672 Uncharacterized conserved low complexity protein Cluster-8309.48970 BP_3 451.36 6.58 3600 642932794 XP_974082.2 1670 5.3e-183 PREDICTED: dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [Tribolium castaneum] 755973707 XM_011308799.1 131 2.45761e-59 PREDICTED: Fopius arisanus dual specificity mitogen-activated protein kinase kinase 4-like (LOC105268902), mRNA K04430 MAP2K4, MKK4 mitogen-activated protein kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04430 P47809 1129 1.2e-121 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 PF00069//PF04196//PF07714 Protein kinase domain//Bunyavirus RNA dependent RNA polymerase//Protein tyrosine kinase GO:0006468//GO:0006144//GO:0006351//GO:0019079 protein phosphorylation//purine nucleobase metabolic process//transcription, DNA-templated//viral genome replication GO:0005524//GO:0004672//GO:0003968 ATP binding//protein kinase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4 Cluster-8309.48972 BP_3 27.21 3.88 630 91089745 XP_975162.1 252 2.5e-19 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 Q1RMT7 205 2.9e-15 Serine/threonine-protein kinase RIO3 OS=Bos taurus GN=RIOK3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.48974 BP_3 2.00 8.60 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48975 BP_3 20.35 0.31 3481 642915800 XP_008200083.1 907 1.5e-94 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum] -- -- -- -- -- K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q62371 527 7.2e-52 Discoidin domain-containing receptor 2 OS=Mus musculus GN=Ddr2 PE=1 SV=2 PF07714//PF00069//PF02133 Protein tyrosine kinase//Protein kinase domain//Permease for cytosine/purines, uracil, thiamine, allantoin GO:0006810//GO:0006468//GO:0055085 transport//protein phosphorylation//transmembrane transport GO:0004672//GO:0005215//GO:0005524 protein kinase activity//transporter activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.48976 BP_3 125.27 1.67 3903 646702401 KDR11613.1 2165 2.3e-240 Mothers against decapentaplegic-like protein 4 [Zootermopsis nevadensis] 552954715 KF307635.1 131 2.66655e-59 Pinctada fucata TGF beta signaling pathway factor (smad4) mRNA, complete cds K04501 SMAD4 mothers against decapentaplegic homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04501 Q9GKQ9 1075 2.3e-115 Mothers against decapentaplegic homolog 4 OS=Sus scrofa GN=SMAD4 PE=2 SV=1 PF03166//PF03165 MH2 domain//MH1 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.48977 BP_3 17.79 1.35 928 642925141 XP_008194443.1 278 3.5e-22 PREDICTED: sex lethal isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48982 BP_3 250.35 14.28 1137 91088115 XP_969791.1 1073 2.8e-114 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 238 2.5145e-119 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 962 8.5e-103 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0008026 ATP binding//DNA binding//hydrolase activity//nucleic acid binding//ATP-dependent helicase activity -- -- KOG0330 ATP-dependent RNA helicase Cluster-8309.48984 BP_3 74.00 2.14 1956 478253983 ENN74275.1 451 6.4e-42 hypothetical protein YQE_09247, partial [Dendroctonus ponderosae]>gi|546673743|gb|ERL85299.1| hypothetical protein D910_02720 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48986 BP_3 184.00 9.67 1209 91087143 XP_975288.1 1046 4.0e-111 PREDICTED: exosome complex component MTR3 [Tribolium castaneum] -- -- -- -- -- K12587 MTR3, EXOSC6 exosome complex component MTR3 http://www.genome.jp/dbget-bin/www_bget?ko:K12587 Q6P0I8 438 5.3e-42 Exosome complex component MTR3 OS=Danio rerio GN=exosc6 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1068 Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases Cluster-8309.48987 BP_3 520.82 5.94 4515 642910521 XP_008200247.1 918 1.0e-95 PREDICTED: muscle M-line assembly protein unc-89-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48988 BP_3 376.92 3.18 6000 91082203 XP_972014.1 3609 0.0e+00 PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922206|ref|XP_008193062.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922209|ref|XP_008193063.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|270007229|gb|EFA03677.1| hypothetical protein TcasGA2_TC013779 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02466 665 1.2e-67 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF00069//PF03139//PF07714//PF05676 Protein kinase domain//Vanadium/alternative nitrogenase delta subunit//Protein tyrosine kinase//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GO:0015992//GO:0055114//GO:0006118//GO:0006814//GO:0006468//GO:0009399//GO:0006120//GO:0006807//GO:0006744//GO:0016310//GO:0019337 proton transport//oxidation-reduction process//obsolete electron transport//sodium ion transport//protein phosphorylation//nitrogen fixation//mitochondrial electron transport, NADH to ubiquinone//nitrogen compound metabolic process//ubiquinone biosynthetic process//phosphorylation//tetrachloroethylene catabolic process GO:0016163//GO:0008137//GO:0000166//GO:0005524//GO:0004672//GO:0003954 nitrogenase activity//NADH dehydrogenase (ubiquinone) activity//nucleotide binding//ATP binding//protein kinase activity//NADH dehydrogenase activity GO:0016610//GO:0005739 nitrogenase complex//mitochondrion KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.48990 BP_3 326.68 4.36 3906 642925947 XP_008194707.1 681 2.7e-68 PREDICTED: uncharacterized protein LOC103313387, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48993 BP_3 10.00 4.43 399 383847897 XP_003699589.1 422 3.0e-39 PREDICTED: 60S ribosomal protein L35a [Megachile rotundata] 262401316 FJ774840.1 179 5.24099e-87 Scylla paramamosain ribosomal protein L35A mRNA, partial cds K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 P61272 380 9.1e-36 60S ribosomal protein L35a OS=Macaca fascicularis GN=RPL35A PE=3 SV=1 PF01247 Ribosomal protein L35Ae GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0887 60S ribosomal protein L35A/L37 Cluster-8309.48994 BP_3 391.57 11.09 1993 91083711 XP_969979.1 1185 5.1e-127 PREDICTED: dnaJ homolog subfamily B member 13 [Tribolium castaneum]>gi|270006809|gb|EFA03257.1| hypothetical protein TcasGA2_TC013191 [Tribolium castaneum] -- -- -- -- -- K09519 DNAJB13 DnaJ homolog subfamily B member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09519 Q80Y75 555 2.3e-55 DnaJ homolog subfamily B member 13 OS=Mus musculus GN=Dnajb13 PE=2 SV=1 PF04961//PF11744 Formiminotransferase-cyclodeaminase//Aluminium activated malate transporter GO:0044237//GO:0015743//GO:0006457 cellular metabolic process//malate transport//protein folding GO:0051082//GO:0031072//GO:0003824 unfolded protein binding//heat shock protein binding//catalytic activity -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.48995 BP_3 53.32 1.63 1872 546683908 ERL93656.1 1982 1.8e-219 hypothetical protein D910_10944 [Dendroctonus ponderosae] 195130912 XM_002009859.1 179 2.62887e-86 Drosophila mojavensis GI14989 (Dmoj\GI14989), mRNA -- -- -- -- Q80XJ3 846 4.0e-89 Tetratricopeptide repeat protein 28 OS=Mus musculus GN=Ttc28 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48998 BP_3 105.56 1.27 4309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4900 BP_3 18.00 0.64 1655 829782570 XP_012623491.1 170 2.1e-09 PREDICTED: piggyBac transposable element-derived protein 4 isoform X1 [Microcebus murinus]>gi|829782575|ref|XP_012623492.1| PREDICTED: piggyBac transposable element-derived protein 4 isoform X1 [Microcebus murinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49000 BP_3 118.25 0.60 9849 270006808 EFA03256.1 1963 1.5e-216 hypothetical protein TcasGA2_TC013190 [Tribolium castaneum] 642924343 XM_008196035.1 453 0 PREDICTED: Tribolium castaneum voltage-gated potassium channel subunit beta-2 (LOC658668), mRNA K04883 KCNAB2 potassium voltage-gated channel Shaker-related subfamily A, beta member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04883 Q27955 988 7.2e-105 Voltage-gated potassium channel subunit beta-2 OS=Bos taurus GN=KCNAB2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1575 Voltage-gated shaker-like K+ channel, subunit beta/KCNAB Cluster-8309.49003 BP_3 360.33 16.32 1356 642911486 XP_008199444.1 557 2.3e-54 PREDICTED: Na(+)/H(+) exchange regulatory cofactor NHE-RF2 [Tribolium castaneum]>gi|270014790|gb|EFA11238.1| hypothetical protein TcasGA2_TC010770 [Tribolium castaneum] -- -- -- -- -- K13358 SLC9A3R2, NHERF2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 http://www.genome.jp/dbget-bin/www_bget?ko:K13358 Q5ZM14 257 5.7e-21 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Gallus gallus GN=SLC9A3R1 PE=2 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.49004 BP_3 25.28 0.61 2305 332376577 AEE63428.1 1040 3.8e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 550 1.0e-54 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722//PF11522 Peptidase C26//Yeast phosphatidylinositol-4-OH kinase Pik1 GO:0006541 glutamine metabolic process GO:0016773//GO:0016787 phosphotransferase activity, alcohol group as acceptor//hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.49005 BP_3 216.63 3.61 3185 642924174 XP_008194038.1 1263 7.3e-136 PREDICTED: LOW QUALITY PROTEIN: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like [Tribolium castaneum] -- -- -- -- -- K05544 DUS3 tRNA-dihydrouridine synthase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05544 Q28BT8 798 2.5e-83 tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Xenopus tropicalis GN=dus3l PE=2 SV=2 PF00642//PF01207 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Dihydrouridine synthase (Dus) GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0017150//GO:0046872//GO:0050660 tRNA dihydrouridine synthase activity//metal ion binding//flavin adenine dinucleotide binding -- -- KOG2333 Uncharacterized conserved protein Cluster-8309.49006 BP_3 410.84 5.00 4256 642937533 XP_008199086.1 1403 5.7e-152 PREDICTED: F-box only protein 9 [Tribolium castaneum] -- -- -- -- -- K10295 FBXO9 F-box protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10295 Q3ZBT2 828 1.1e-86 F-box only protein 9 OS=Bos taurus GN=FBXO9 PE=2 SV=2 PF00646//PF00515//PF13181//PF13414//PF12937//PF03006 F-box domain//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//F-box-like//Haemolysin-III related -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2997 F-box protein FBX9 Cluster-8309.49007 BP_3 44.66 1.20 2084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4901 BP_3 14.73 0.43 1944 642919042 XP_008191709.1 435 4.6e-40 PREDICTED: hyaluronan mediated motility receptor-like [Tribolium castaneum]>gi|270005720|gb|EFA02168.1| hypothetical protein TcasGA2_TC007824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96YR5 224 5.5e-17 DNA double-strand break repair Rad50 ATPase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=rad50 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49011 BP_3 939.20 23.64 2207 270000870 EEZ97317.1 1522 4.7e-166 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 46 2.67185e-12 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 226 3.7e-17 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 PF08476 Viral D10 N-terminal -- -- GO:0016791 phosphatase activity -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.49012 BP_3 497.13 8.83 3005 270000870 EEZ97317.1 1789 7.0e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.10608e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.4e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.49013 BP_3 548.38 4.69 5922 768446798 XP_011565358.1 1006 8.6e-106 PREDICTED: leucine-rich PPR motif-containing protein, mitochondrial-like [Plutella xylostella] 752871555 XM_011254679.1 92 1.94257e-37 PREDICTED: Camponotus floridanus 60S ribosome subunit biogenesis protein NIP7 homolog (LOC105249313), mRNA K07565 NIP7 60S ribosome subunit biogenesis protein NIP7 http://www.genome.jp/dbget-bin/www_bget?ko:K07565 Q503P2 684 7.7e-70 60S ribosome subunit biogenesis protein NIP7 homolog OS=Danio rerio GN=nip7 PE=2 SV=1 PF03002//PF13181//PF08686//PF03973//PF13176//PF04369//PF01472 Somatostatin/Cortistatin family//Tetratricopeptide repeat//PLAC (protease and lacunin) domain//Triabin//Tetratricopeptide repeat//Lactococcin-like family//PUA domain GO:0030682//GO:0042742//GO:0007165 evasion or tolerance of host defense response//defense response to bacterium//signal transduction GO:0008233//GO:0003723//GO:0005515//GO:0005179 peptidase activity//RNA binding//protein binding//hormone activity GO:0005576 extracellular region KOG3492 Ribosome biogenesis protein NIP7 Cluster-8309.49014 BP_3 907.26 15.41 3129 642916755 XP_008192481.1 2591 7.3e-290 PREDICTED: nuclear valosin-containing protein-like [Tribolium castaneum] 124087411 XM_001346809.1 35 4.95521e-06 Paramecium tetraurelia strain d4-2 >gnl|BL_ORD_ID|3811472 Paramecium tetraurelia hypothetical protein (GSPATT00000539001) partial mRNA K14571 RIX7, NVL ribosome biogenesis ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14571 O15381 1068 1.2e-114 Nuclear valosin-containing protein-like OS=Homo sapiens GN=NVL PE=1 SV=1 PF07726//PF00005//PF01637//PF01118//PF10662//PF00910//PF14532//PF06068//PF05496//PF01443//PF00437//PF07724//PF06414//PF02367//PF02562//PF00931//PF07728//PF01695//PF00158//PF01057//PF00004 ATPase family associated with various cellular activities (AAA)//ABC transporter//Archaeal ATPase//Semialdehyde dehydrogenase, NAD binding domain//Ethanolamine utilisation - propanediol utilisation//RNA helicase//Sigma-54 interaction domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//NB-ARC domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//ATPase family associated with various cellular activities (AAA) GO:0006576//GO:0002949//GO:0006310//GO:0006810//GO:0006281//GO:0019079//GO:0055114//GO:0006355 cellular biogenic amine metabolic process//tRNA threonylcarbamoyladenosine modification//DNA recombination//transport//DNA repair//viral genome replication//oxidation-reduction process//regulation of transcription, DNA-templated GO:0051287//GO:0043531//GO:0003678//GO:0003723//GO:0009378//GO:0003724//GO:0008134//GO:0005524//GO:0016620//GO:0016301//GO:0016887 NAD binding//ADP binding//DNA helicase activity//RNA binding//four-way junction helicase activity//RNA helicase activity//transcription factor binding//ATP binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//kinase activity//ATPase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0733 Nuclear AAA ATPase (VCP subfamily) Cluster-8309.49015 BP_3 14.00 3.62 478 642939494 XP_008190865.1 433 1.9e-40 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54FB7 179 2.2e-12 Xanthine dehydrogenase OS=Dictyostelium discoideum GN=xdh PE=3 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0003824//GO:0043167//GO:0016491 catalytic activity//ion binding//oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.49017 BP_3 10.77 0.31 1959 332375110 AEE62696.1 1843 2.5e-203 unknown [Dendroctonus ponderosae]>gi|478257862|gb|ENN78004.1| hypothetical protein YQE_05524, partial [Dendroctonus ponderosae]>gi|546674573|gb|ERL85926.1| hypothetical protein D910_03341 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O15244 663 6.9e-68 Solute carrier family 22 member 2 OS=Homo sapiens GN=SLC22A2 PE=1 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49018 BP_3 38.00 2.92 920 642923341 XP_008193709.1 745 2.4e-76 PREDICTED: peptidyl-prolyl cis-trans isomerase-like [Tribolium castaneum] -- -- -- -- -- K03768 PPIB, ppiB peptidyl-prolyl cis-trans isomerase B (cyclophilin B) http://www.genome.jp/dbget-bin/www_bget?ko:K03768 P28517 548 7.0e-55 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme OS=Calliphora vicina GN=NINAA PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0880 Peptidyl-prolyl cis-trans isomerase Cluster-8309.49019 BP_3 167.31 4.08 2270 642910948 XP_008193477.1 2276 1.8e-253 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 1570 5.4e-173 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF02897//PF00326 Prolyl oligopeptidase, N-terminal beta-propeller domain//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0070008//GO:0008236//GO:0004252 serine-type exopeptidase activity//serine-type peptidase activity//serine-type endopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.49020 BP_3 160.93 4.60 1979 91090484 XP_968697.1 513 4.2e-49 PREDICTED: DNA-directed RNA polymerase III subunit RPC4 [Tribolium castaneum]>gi|270013359|gb|EFA09807.1| hypothetical protein TcasGA2_TC011952 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05423 164 5.1e-10 DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens GN=POLR3D PE=1 SV=2 PF05132 RNA polymerase III RPC4 GO:0006383//GO:0006351//GO:0006144//GO:0006206 transcription from RNA polymerase III promoter//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005666 nucleolus//DNA-directed RNA polymerase III complex -- -- Cluster-8309.49021 BP_3 16.07 0.48 1894 642913668 XP_008201109.1 1299 2.9e-140 PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913670|ref|XP_008201110.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913672|ref|XP_008201111.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913674|ref|XP_008201112.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913676|ref|XP_008201113.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913678|ref|XP_008201114.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WTW5 614 3.2e-62 Solute carrier family 22 member 3 OS=Mus musculus GN=Slc22a3 PE=2 SV=1 PF01272//PF07690//PF00083 Transcription elongation factor, GreA/GreB, C-term//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0032784 transmembrane transport//regulation of DNA-templated transcription, elongation GO:0003677//GO:0022857 DNA binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.49022 BP_3 113.96 1.22 4801 746863121 XP_011062509.1 3108 0.0e+00 PREDICTED: neither inactivation nor afterpotential protein C isoform X1 [Acromyrmex echinatior]>gi|746863123|ref|XP_011062510.1| PREDICTED: neither inactivation nor afterpotential protein C isoform X1 [Acromyrmex echinatior] -- -- -- -- -- K08834 MYO3, DFNB30 myosin III http://www.genome.jp/dbget-bin/www_bget?ko:K08834 P10676 2652 3.9e-298 Neither inactivation nor afterpotential protein C OS=Drosophila melanogaster GN=ninaC PE=1 SV=2 PF01991//PF07714//PF05337//PF00063//PF00612//PF06293//PF00069 ATP synthase (E/31 kDa) subunit//Protein tyrosine kinase//Macrophage colony stimulating factor-1 (CSF-1)//Myosin head (motor domain)//IQ calmodulin-binding motif//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0040007//GO:0015991//GO:0008283//GO:0006119//GO:0015992//GO:0007165//GO:0006468 growth//ATP hydrolysis coupled proton transport//cell proliferation//oxidative phosphorylation//proton transport//signal transduction//protein phosphorylation GO:0003774//GO:0016773//GO:0004672//GO:0008083//GO:0005515//GO:0005125//GO:0046961//GO:0005524 motor activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//growth factor activity//protein binding//cytokine activity//proton-transporting ATPase activity, rotational mechanism//ATP binding GO:0016020//GO:0016459//GO:0016021//GO:0033178 membrane//myosin complex//integral component of membrane//proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.49023 BP_3 53.21 1.79 1728 642916443 XP_008191029.1 1489 2.5e-162 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum]>gi|642916445|ref|XP_008191030.1| PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum] 572301862 XM_006616904.1 66 1.58734e-23 PREDICTED: Apis dorsata transmembrane and coiled-coil domains protein 2-like (LOC102681558), transcript variant X6, mRNA -- -- -- -- Q80W04 647 4.4e-66 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF00606//PF04513//PF08702//PF02601//PF02184//PF05073//PF03462//PF05478//PF05929//PF05531//PF07851 Herpesvirus Glycoprotein B//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//HAT (Half-A-TPR) repeat//Baculovirus P24 capsid protein//PCRF domain//Prominin//Phage capsid scaffolding protein (GPO) serine peptidase//Nucleopolyhedrovirus P10 protein//TMPIT-like protein GO:0030168//GO:0019069//GO:0006308//GO:0006449//GO:0006415//GO:0006396//GO:0007165//GO:0051258 platelet activation//viral capsid assembly//DNA catabolic process//regulation of translational termination//translational termination//RNA processing//signal transduction//protein polymerization GO:0030674//GO:0016149//GO:0008855//GO:0005102//GO:0005198 protein binding, bridging//translation release factor activity, codon specific//exodeoxyribonuclease VII activity//receptor binding//structural molecule activity GO:0016020//GO:0019031//GO:0005622//GO:0005840//GO:0009318//GO:0005737//GO:0005577//GO:0018444//GO:0019028//GO:0016021 membrane//viral envelope//intracellular//ribosome//exodeoxyribonuclease VII complex//cytoplasm//fibrinogen complex//translation release factor complex//viral capsid//integral component of membrane KOG3850 Predicted membrane protein Cluster-8309.49024 BP_3 113.49 0.82 6938 546674893 ERL86179.1 3041 0.0e+00 hypothetical protein D910_03592, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 2.07678e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1895 3.4e-210 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.49026 BP_3 70.72 2.56 1623 189241213 XP_970686.2 1339 5.7e-145 PREDICTED: peroxisomal targeting signal 1 receptor isoform X1 [Tribolium castaneum]>gi|270013260|gb|EFA09708.1| hypothetical protein TcasGA2_TC011841 [Tribolium castaneum] 462302391 APGK01050245.1 53 2.50913e-16 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 635 1.0e-64 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF13414//PF13181//PF00515//PF13371 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1125 TPR repeat-containing protein Cluster-8309.49027 BP_3 53.26 0.52 5195 642926835 XP_008195033.1 610 6.2e-60 PREDICTED: cyclin-L1 [Tribolium castaneum]>gi|270009183|gb|EFA05631.1| hypothetical protein TcasGA2_TC015839 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S94 415 1.0e-38 Cyclin-L2 OS=Homo sapiens GN=CCNL2 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355//GO:0006396//GO:0000079 regulation of transcription, DNA-templated//RNA processing//regulation of cyclin-dependent protein serine/threonine kinase activity GO:0019901//GO:0003700 protein kinase binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.49028 BP_3 22.00 2.82 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49029 BP_3 130.25 1.29 5170 642926835 XP_008195033.1 610 6.2e-60 PREDICTED: cyclin-L1 [Tribolium castaneum]>gi|270009183|gb|EFA05631.1| hypothetical protein TcasGA2_TC015839 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S94 415 1.0e-38 Cyclin-L2 OS=Homo sapiens GN=CCNL2 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355//GO:0006396//GO:0000079 regulation of transcription, DNA-templated//RNA processing//regulation of cyclin-dependent protein serine/threonine kinase activity GO:0019901//GO:0003700 protein kinase binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.49030 BP_3 48.02 1.65 1696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00260 Protamine P1 GO:0007283 spermatogenesis GO:0003677 DNA binding GO:0000786//GO:0005634 nucleosome//nucleus -- -- Cluster-8309.49031 BP_3 707.00 53.56 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11023//PF03176//PF04987 Zinc-ribbon containing domain//MMPL family//Phosphatidylinositolglycan class N (PIG-N) GO:0006506 GPI anchor biosynthetic process GO:0016740 transferase activity GO:0005887//GO:0016020//GO:0005789 integral component of plasma membrane//membrane//endoplasmic reticulum membrane -- -- Cluster-8309.49033 BP_3 36.83 1.39 1566 546673667 ERL85231.1 1312 7.4e-142 hypothetical protein D910_02652 [Dendroctonus ponderosae] -- -- -- -- -- K06990 K06990 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06990 Q6GNT9 958 3.4e-102 Protein MEMO1 OS=Xenopus laevis GN=memo1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3086 Predicted dioxygenase Cluster-8309.49034 BP_3 66.05 0.61 5502 270009638 EFA06086.1 4231 0.0e+00 hypothetical protein TcasGA2_TC008923 [Tribolium castaneum] 817193412 XM_012416742.1 242 7.44193e-121 PREDICTED: Orussus abietinus unconventional myosin-VIIb-like (LOC105695296), transcript variant X2, mRNA -- -- -- -- Q8IVE3 343 2.5e-30 Pleckstrin homology domain-containing family H member 2 OS=Homo sapiens GN=PLEKHH2 PE=1 SV=2 PF02196//PF03359//PF00887//PF00784//PF08416//PF00788 Raf-like Ras-binding domain//Guanylate-kinase-associated protein (GKAP) protein//Acyl CoA binding protein//MyTH4 domain//Phosphotyrosine-binding domain//Ras association (RalGDS/AF-6) domain GO:0007165//GO:0023052 signal transduction//signaling GO:0000062//GO:0005057//GO:0005515 fatty-acyl-CoA binding//receptor signaling protein activity//protein binding GO:0005856 cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.49035 BP_3 300.98 8.05 2093 91091126 XP_969575.1 962 3.8e-101 PREDICTED: magnesium transporter NIPA2 [Tribolium castaneum]>gi|270013137|gb|EFA09585.1| hypothetical protein TcasGA2_TC011702 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SWX0 863 4.8e-91 Magnesium transporter NIPA2 OS=Bos taurus GN=NIPA2 PE=2 SV=1 PF05653//PF00892 Magnesium transporter NIPA//EamA-like transporter family GO:0015693 magnesium ion transport GO:0015095 magnesium ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2922 Uncharacterized conserved protein Cluster-8309.49037 BP_3 29.13 0.58 2713 91091126 XP_969575.1 384 5.2e-34 PREDICTED: magnesium transporter NIPA2 [Tribolium castaneum]>gi|270013137|gb|EFA09585.1| hypothetical protein TcasGA2_TC011702 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8Q9 350 1.9e-31 Magnesium transporter NIPA2 OS=Homo sapiens GN=NIPA2 PE=2 SV=1 PF00892//PF05653 EamA-like transporter family//Magnesium transporter NIPA GO:0015693 magnesium ion transport GO:0015095 magnesium ion transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2922 Uncharacterized conserved protein Cluster-8309.49038 BP_3 10.95 4.99 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04517 Microvirus lysis protein (E), C terminus GO:0019054 modulation by virus of host process GO:0004857 enzyme inhibitor activity -- -- -- -- Cluster-8309.49040 BP_3 402.78 4.31 4800 91090806 XP_970749.1 4595 0.0e+00 PREDICTED: ubiquitin-protein ligase E3B [Tribolium castaneum]>gi|270013259|gb|EFA09707.1| hypothetical protein TcasGA2_TC011840 [Tribolium castaneum] 642935863 XM_965656.2 556 0 PREDICTED: Tribolium castaneum ubiquitin-protein ligase E3B (LOC659339), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q08CZ0 2754 5.8e-310 Ubiquitin-protein ligase E3B OS=Xenopus tropicalis GN=ube3b PE=2 SV=1 PF00632//PF00612 HECT-domain (ubiquitin-transferase)//IQ calmodulin-binding motif GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.49041 BP_3 18.77 0.73 1532 642929994 XP_008196057.1 217 6.8e-15 PREDICTED: uncharacterized protein LOC664557 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0055114//GO:0006570//GO:0006118 oxidation-reduction process//tyrosine metabolic process//obsolete electron transport GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.49043 BP_3 389.00 30.57 905 91092040 XP_969867.1 628 8.9e-63 PREDICTED: probable phospholipid hydroperoxide glutathione peroxidase [Tribolium castaneum]>gi|270004921|gb|EFA01369.1| hypothetical protein TcasGA2_TC010354 [Tribolium castaneum] -- -- -- -- -- K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q9LEF0 441 1.8e-42 Probable phospholipid hydroperoxide glutathione peroxidase OS=Mesembryanthemum crystallinum GN=GPXMC1 PE=2 SV=1 PF00578//PF08534//PF00255 AhpC/TSA family//Redoxin//Glutathione peroxidase GO:0055114//GO:0006804//GO:0006979//GO:0006749 oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress//glutathione metabolic process GO:0004602//GO:0016209//GO:0004601//GO:0016491 glutathione peroxidase activity//antioxidant activity//peroxidase activity//oxidoreductase activity -- -- KOG1651 Glutathione peroxidase Cluster-8309.49044 BP_3 451.99 22.20 1273 91087635 XP_973117.1 1195 2.2e-128 PREDICTED: proteasome subunit alpha type-5 [Tribolium castaneum]>gi|642930329|ref|XP_008196349.1| PREDICTED: proteasome subunit alpha type-5 [Tribolium castaneum]>gi|270009423|gb|EFA05871.1| hypothetical protein TcasGA2_TC008671 [Tribolium castaneum] 571526488 XM_006557223.1 230 7.90016e-115 PREDICTED: Apis mellifera proteasome alpha5 subunit (Prosalpha5), mRNA K02729 PSMA5 20S proteasome subunit alpha 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02729 Q95083 984 2.7e-105 Proteasome subunit alpha type-5 OS=Drosophila melanogaster GN=Prosalpha5 PE=2 SV=2 PF00227//PF10584 Proteasome subunit//Proteasome subunit A N-terminal signature GO:0051603//GO:0006511 proteolysis involved in cellular protein catabolic process//ubiquitin-dependent protein catabolic process GO:0004298//GO:0004175 threonine-type endopeptidase activity//endopeptidase activity GO:0019773//GO:0005737//GO:0005839//GO:0005634 proteasome core complex, alpha-subunit complex//cytoplasm//proteasome core complex//nucleus KOG0176 20S proteasome, regulatory subunit alpha type PSMA5/PUP2 Cluster-8309.49046 BP_3 592.94 16.55 2019 642924856 XP_008194068.1 1494 7.6e-163 PREDICTED: trypsin-3 [Tribolium castaneum]>gi|270008121|gb|EFA04569.1| serine protease P133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81286 420 1.1e-39 Plasminogen (Fragment) OS=Ovis aries GN=PLG PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.49047 BP_3 51.58 0.38 6755 546676860 ERL87797.1 1674 3.4e-183 hypothetical protein D910_05186 [Dendroctonus ponderosae] 512862182 XM_002935331.2 57 6.33947e-18 PREDICTED: Xenopus (Silurana) tropicalis enhancer of rudimentary homolog (Drosophila) (erh), mRNA -- -- -- -- Q8NBJ9 1125 6.4e-121 SID1 transmembrane family member 2 OS=Homo sapiens GN=SIDT2 PE=1 SV=2 PF08030//PF01133//PF00097//PF00175//PF13965 Ferric reductase NAD binding domain//Enhancer of rudimentary//Zinc finger, C3HC4 type (RING finger)//Oxidoreductase NAD-binding domain//dsRNA-gated channel SID-1 GO:0045747//GO:0015931//GO:0006221//GO:0033227//GO:0007049//GO:0055114 positive regulation of Notch signaling pathway//nucleobase-containing compound transport//pyrimidine nucleotide biosynthetic process//dsRNA transport//cell cycle//oxidation-reduction process GO:0016491//GO:0046872//GO:0051033 oxidoreductase activity//metal ion binding//RNA transmembrane transporter activity GO:0016021 integral component of membrane KOG1766 Enhancer of rudimentary Cluster-8309.49048 BP_3 1110.56 9.79 5757 546682075 ERL92061.1 4429 0.0e+00 hypothetical protein D910_09383 [Dendroctonus ponderosae] -- -- -- -- -- K06101 ASH1L histone-lysine N-methyltransferase ASH1L http://www.genome.jp/dbget-bin/www_bget?ko:K06101 Q9VW15 2095 1.8e-233 Histone-lysine N-methyltransferase ash1 OS=Drosophila melanogaster GN=ash1 PE=1 SV=3 PF00439//PF00856//PF01426//PF02378//PF00628 Bromodomain//SET domain//BAH domain//Phosphotransferase system, EIIC//PHD-finger GO:0009401//GO:0008643 phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport GO:0005515//GO:0008982//GO:0003682 protein binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//chromatin binding GO:0000785//GO:0009357//GO:0016020 chromatin//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.49053 BP_3 201.00 6.03 1898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49054 BP_3 105.01 2.45 2358 642927459 XP_968905.2 1040 3.9e-110 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q3SZJ4 752 4.0e-78 Prostaglandin reductase 1 OS=Bos taurus GN=PTGR1 PE=2 SV=1 PF00107//PF02826//PF00106//PF01118//PF01370 Zinc-binding dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//short chain dehydrogenase//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0051287//GO:0016491//GO:0016620 coenzyme binding//catalytic activity//NAD binding//oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- -- -- Cluster-8309.49055 BP_3 617.00 6.89 4611 478256707 ENN76889.1 1972 6.5e-218 hypothetical protein YQE_06730, partial [Dendroctonus ponderosae]>gi|546685095|gb|ERL94622.1| hypothetical protein D910_11898 [Dendroctonus ponderosae] 880935623 XM_005079858.2 48 4.34923e-13 PREDICTED: Mesocricetus auratus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (Dyrk3), mRNA K18669 DYRK2_3_4 dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18669 Q5ZIU3 1711 4.9e-189 Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Gallus gallus GN=DYRK2 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.49057 BP_3 177.00 5.74 1777 642911746 XP_008200724.1 1659 4.9e-182 PREDICTED: protein MON2 homolog isoform X2 [Tribolium castaneum] 462386069 APGK01020363.1 46 2.14289e-12 Dendroctonus ponderosae Seq01020373, whole genome shotgun sequence -- -- -- -- Q9VLT1 1223 7.3e-133 Protein MON2 homolog OS=Drosophila melanogaster GN=mon2 PE=2 SV=4 PF07464 Apolipophorin-III precursor (apoLp-III) GO:0006869 lipid transport GO:0008289 lipid binding GO:0005576 extracellular region KOG1848 Uncharacterized conserved protein Cluster-8309.49058 BP_3 865.38 10.17 4395 642911744 XP_008200722.1 5379 0.0e+00 PREDICTED: protein MON2 homolog isoform X1 [Tribolium castaneum]>gi|270014560|gb|EFA11008.1| hypothetical protein TcasGA2_TC004594 [Tribolium castaneum] 805783467 XM_012284434.1 38 1.50099e-07 PREDICTED: Megachile rotundata protein MON2 homolog (LOC100878853), transcript variant X3, mRNA -- -- -- -- Q9VLT1 3816 0.0e+00 Protein MON2 homolog OS=Drosophila melanogaster GN=mon2 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG1848 Uncharacterized conserved protein Cluster-8309.4906 BP_3 21.47 0.44 2618 189241917 XP_971431.2 1467 1.3e-159 PREDICTED: rho GTPase-activating protein 19 isoform X1 [Tribolium castaneum]>gi|270016794|gb|EFA13240.1| hypothetical protein TcasGA2_TC001510 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INE5 272 2.0e-22 Rho GTPase-activating protein 19 OS=Xenopus laevis GN=arhgap19 PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.49060 BP_3 67.11 1.30 2775 642918280 XP_008191442.1 388 1.8e-34 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] -- -- -- -- -- K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 371 7.1e-34 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.49062 BP_3 17.00 2.00 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49063 BP_3 2.00 0.48 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49065 BP_3 22.74 0.64 2016 642935211 XP_008199691.1 660 3.9e-66 PREDICTED: RNA-binding protein Musashi homolog Rbp6 isoform X1 [Tribolium castaneum] 642935212 XM_008201470.1 333 6.98901e-172 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog Rbp6 (LOC656553), transcript variant X2, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q9VVE5 345 5.3e-31 RNA-binding protein Musashi homolog Rbp6 OS=Drosophila melanogaster GN=Rbp6 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49066 BP_3 664.15 24.14 1618 642929822 XP_975593.2 1060 1.3e-112 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.66535e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.4e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.49067 BP_3 34.02 0.53 3361 642933365 XP_008197385.1 3874 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49069 BP_3 1.00 2.52 287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49070 BP_3 1050.00 11.70 4616 189233723 XP_970246.2 2880 0.0e+00 PREDICTED: leishmanolysin-like peptidase [Tribolium castaneum] 807037579 XM_004533605.2 92 1.51155e-37 PREDICTED: Ceratitis capitata leishmanolysin-like peptidase (LOC101450918), transcript variant X4, mRNA K13539 LMLN leishmanolysin-like peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K13539 Q29AK2 2313 7.6e-259 Leishmanolysin-like peptidase OS=Drosophila pseudoobscura pseudoobscura GN=GA17800 PE=3 SV=1 PF03491//PF01457 Serotonin (5-HT) neurotransmitter transporter, N-terminus//Leishmanolysin GO:0006508//GO:0006812//GO:0007155//GO:0006836 proteolysis//cation transport//cell adhesion//neurotransmitter transport GO:0005335//GO:0004222 serotonin:sodium symporter activity//metalloendopeptidase activity GO:0016020//GO:0005887 membrane//integral component of plasma membrane KOG2556 Leishmanolysin-like peptidase (Peptidase M8 family) Cluster-8309.49071 BP_3 33.77 0.36 4834 189240517 XP_001812287.1 5551 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X1 [Tribolium castaneum]>gi|270012592|gb|EFA09040.1| hypothetical protein TcasGA2_TC006753 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49072 BP_3 99.48 1.22 4222 642933365 XP_008197385.1 5115 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49073 BP_3 124.50 1.29 4934 189240517 XP_001812287.1 3876 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X1 [Tribolium castaneum]>gi|270012592|gb|EFA09040.1| hypothetical protein TcasGA2_TC006753 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49074 BP_3 693.40 7.48 4762 642933365 XP_008197385.1 5446 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49075 BP_3 4.00 0.38 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49076 BP_3 436.55 7.92 2950 642924301 XP_008194238.1 3160 0.0e+00 PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924303|ref|XP_008194239.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924305|ref|XP_008194240.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K00111 glpA, glpD glycerol-3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00111 A6QLU1 2199 8.1e-246 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Bos taurus GN=GPD2 PE=2 SV=1 PF12831//PF13202//PF00036//PF07992//PF01134//PF13405//PF13833//PF01266//PF13499 FAD dependent oxidoreductase//EF hand//EF hand//Pyridine nucleotide-disulphide oxidoreductase//Glucose inhibited division protein A//EF-hand domain//EF-hand domain pair//FAD dependent oxidoreductase//EF-hand domain pair GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0005509//GO:0050660//GO:0016491 calcium ion binding//flavin adenine dinucleotide binding//oxidoreductase activity -- -- KOG0042 Glycerol-3-phosphate dehydrogenase Cluster-8309.49080 BP_3 447.46 3.96 5738 270014299 EFA10747.1 1625 1.4e-177 hypothetical protein TcasGA2_TC012493 [Tribolium castaneum]>gi|485836784|tpg|DAA64479.1| TPA_inf: ETH-like G protein-coupled receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O93603 396 1.8e-36 Thyrotropin-releasing hormone receptor OS=Gallus gallus GN=TRHR PE=2 SV=1 PF07057//PF05924//PF00001//PF01278 DNA helicase TraI//SAMP Motif//7 transmembrane receptor (rhodopsin family)//Omptin family GO:0000746//GO:0007186//GO:0006508//GO:0016055 conjugation//G-protein coupled receptor signaling pathway//proteolysis//Wnt signaling pathway GO:0016818//GO:0008013//GO:0004175//GO:0003678//GO:0005524//GO:0003677//GO:0004930 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//beta-catenin binding//endopeptidase activity//DNA helicase activity//ATP binding//DNA binding//G-protein coupled receptor activity GO:0016342//GO:0009279//GO:0005657//GO:0016021 catenin complex//cell outer membrane//replication fork//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.49081 BP_3 21.42 0.31 3658 189239121 XP_001815551.1 604 2.2e-59 PREDICTED: lysM and putative peptidoglycan-binding domain-containing protein 2 [Tribolium castaneum]>gi|270010334|gb|EFA06782.1| hypothetical protein TcasGA2_TC009718 [Tribolium castaneum] 766919473 XM_011505860.1 143 5.33042e-66 PREDICTED: Ceratosolen solmsi marchali transcription initiation factor IIA subunit 2 (LOC105367226), mRNA K03123 TFIIA2, GTF2A2, TOA2 transcription initiation factor TFIIA small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03123 P52656 467 6.9e-45 Transcription initiation factor IIA subunit 2 OS=Drosophila melanogaster GN=TfIIA-S PE=1 SV=1 PF02268//PF02751 Transcription initiation factor IIA, gamma subunit, helical domain//Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex KOG3463 Transcription initiation factor IIA, gamma subunit Cluster-8309.49082 BP_3 13.00 0.89 996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49083 BP_3 126.80 1.84 3621 642916443 XP_008191029.1 1482 3.3e-161 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum]>gi|642916445|ref|XP_008191030.1| PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 670 2.0e-68 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF02601//PF00038//PF08702//PF04513//PF02184//PF03462//PF05073//PF05531//PF07851//PF10459//PF05929//PF05478 Exonuclease VII, large subunit//Intermediate filament protein//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//HAT (Half-A-TPR) repeat//PCRF domain//Baculovirus P24 capsid protein//Nucleopolyhedrovirus P10 protein//TMPIT-like protein//Peptidase S46//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin GO:0007165//GO:0051258//GO:0006415//GO:0006396//GO:0006449//GO:0030168//GO:0006308//GO:0019069 signal transduction//protein polymerization//translational termination//RNA processing//regulation of translational termination//platelet activation//DNA catabolic process//viral capsid assembly GO:0005198//GO:0070009//GO:0005102//GO:0016149//GO:0008855//GO:0030674//GO:0008239 structural molecule activity//serine-type aminopeptidase activity//receptor binding//translation release factor activity, codon specific//exodeoxyribonuclease VII activity//protein binding, bridging//dipeptidyl-peptidase activity GO:0016021//GO:0019028//GO:0005882//GO:0005622//GO:0009318//GO:0005840//GO:0005577//GO:0005737//GO:0018444//GO:0019031 integral component of membrane//viral capsid//intermediate filament//intracellular//exodeoxyribonuclease VII complex//ribosome//fibrinogen complex//cytoplasm//translation release factor complex//viral envelope KOG3850 Predicted membrane protein Cluster-8309.49086 BP_3 120.15 0.69 8640 642913355 XP_008195386.1 6061 0.0e+00 PREDICTED: protein polybromo-1 [Tribolium castaneum] -- -- -- -- -- K11757 PBRM1, PB1 protein polybromo-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11757 Q86U86 1886 4.7e-209 Protein polybromo-1 OS=Homo sapiens GN=PBRM1 PE=1 SV=1 PF01426//PF00439//PF00493//PF10505//PF07726//PF07728 BAH domain//Bromodomain//MCM2/3/5 family//NMDA receptor-regulated gene protein 2 C-terminus//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily) GO:0006260 DNA replication GO:0003682//GO:0016887//GO:0005515//GO:0005524//GO:0003677 chromatin binding//ATPase activity//protein binding//ATP binding//DNA binding GO:0000785//GO:0008023 chromatin//transcription elongation factor complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.49088 BP_3 66.54 0.66 5143 546671406 ERL83731.1 2877 0.0e+00 hypothetical protein D910_00944, partial [Dendroctonus ponderosae]>gi|546675549|gb|ERL86722.1| hypothetical protein D910_04128, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24247 1433 9.4e-157 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 PF06529 Vertebrate interleukin-3 regulated transcription factor GO:0007623//GO:0006351 circadian rhythm//transcription, DNA-templated -- -- GO:0005634 nucleus KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.49089 BP_3 75.98 0.56 6822 642937838 XP_008200322.1 3064 0.0e+00 PREDICTED: tyrosine-protein kinase Fps85D isoform X1 [Tribolium castaneum]>gi|270000733|gb|EEZ97180.1| hypothetical protein TcasGA2_TC004367 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1537 1.1e-168 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF09432//PF10541//PF07714//PF05090//PF00069//PF00346 Tho complex subunit THP2//Nuclear envelope localisation domain//Protein tyrosine kinase//Vitamin K-dependent gamma-carboxylase//Protein kinase domain//Respiratory-chain NADH dehydrogenase, 49 Kd subunit GO:0006468//GO:0017187//GO:0006406//GO:0006368//GO:0055114 protein phosphorylation//peptidyl-glutamic acid carboxylation//mRNA export from nucleus//transcription elongation from RNA polymerase II promoter//oxidation-reduction process GO:0051287//GO:0016651//GO:0004713//GO:0005524//GO:0048038//GO:0004672//GO:0008488 NAD binding//oxidoreductase activity, acting on NAD(P)H//protein tyrosine kinase activity//ATP binding//quinone binding//protein kinase activity//gamma-glutamyl carboxylase activity GO:0016021//GO:0000446 integral component of membrane//nucleoplasmic THO complex KOG0194 Protein tyrosine kinase Cluster-8309.49090 BP_3 618.37 12.99 2587 91094503 XP_971555.1 1921 3.0e-212 PREDICTED: tyrosine-protein kinase Fps85D isoform X2 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1546 3.7e-170 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0194 Protein tyrosine kinase Cluster-8309.49094 BP_3 2.00 1.40 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49101 BP_3 39.59 1.55 1523 642936884 XP_969823.3 427 3.0e-39 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 195 9.9e-14 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49102 BP_3 24.16 1.78 945 270001017 EEZ97464.1 326 9.7e-28 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 247 5.8e-20 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF02137 Adenosine-deaminase (editase) domain GO:0006144//GO:0006807//GO:0006396 purine nucleobase metabolic process//nitrogen compound metabolic process//RNA processing GO:0003723//GO:0004000 RNA binding//adenosine deaminase activity -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.49104 BP_3 891.42 17.03 2815 805765285 XP_012134962.1 832 6.1e-86 PREDICTED: peptidyl-prolyl cis-trans isomerase cyp11 isoform X2 [Megachile rotundata] 645259408 XM_008237125.1 62 4.35866e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 O55035 612 8.1e-62 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.49106 BP_3 102.08 0.65 7816 123407101 XP_001302933.1 225 4.1e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.5e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49107 BP_3 44.59 1.49 1732 478257465 ENN77621.1 438 1.8e-40 hypothetical protein YQE_05915, partial [Dendroctonus ponderosae]>gi|546679859|gb|ERL90247.1| hypothetical protein D910_07599 [Dendroctonus ponderosae] 665389295 NM_001297885.1 50 1.24752e-14 Drosophila melanogaster vinculin (Vinc), transcript variant C, mRNA K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 359 1.1e-32 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF01608 Vinculin family//I/LWEQ domain GO:0007155 cell adhesion GO:0003779//GO:0051015 actin binding//actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.49109 BP_3 11.55 2.76 493 270005102 EFA01550.1 399 1.7e-36 hypothetical protein TcasGA2_TC007111 [Tribolium castaneum] -- -- -- -- -- K17602 YLPM1 YLP motif-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17602 Q9R0I7 193 5.5e-14 YLP motif-containing protein 1 OS=Mus musculus GN=Ylpm1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4911 BP_3 1.00 0.33 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49110 BP_3 164.17 1.71 4917 728417025 AIY68331.1 3330 0.0e+00 putative gliotactin [Leptinotarsa decemlineata] 645019941 XM_008208782.1 54 2.14363e-16 PREDICTED: Nasonia vitripennis gliotactin (LOC100120557), transcript variant X3, mRNA -- -- -- -- Q8NFZ3 621 1.3e-62 Neuroligin-4, Y-linked OS=Homo sapiens GN=NLGN4Y PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.49111 BP_3 136.74 3.28 2303 91084545 XP_973071.1 1808 3.4e-199 PREDICTED: tudor domain-containing protein 7 isoform X1 [Tribolium castaneum]>gi|270008665|gb|EFA05113.1| hypothetical protein TcasGA2_TC015214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.0e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49113 BP_3 10.00 6.84 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49114 BP_3 24.00 3.62 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49115 BP_3 9.00 0.33 1620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07655//PF13965//PF06524 Secretin N-terminal domain//dsRNA-gated channel SID-1//NOA36 protein GO:0033227//GO:0015931//GO:0009297 dsRNA transport//nucleobase-containing compound transport//pilus assembly GO:0051033//GO:0008270 RNA transmembrane transporter activity//zinc ion binding GO:0019867//GO:0005634//GO:0016021 outer membrane//nucleus//integral component of membrane -- -- Cluster-8309.49116 BP_3 5.14 0.42 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4912 BP_3 4.00 0.90 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49120 BP_3 20.47 0.74 1616 642915590 XP_008190678.1 1743 8.1e-192 PREDICTED: tyrosine-protein phosphatase Lar isoform X4 [Tribolium castaneum] -- -- -- -- -- K06777 PTPRD receptor-type tyrosine-protein phosphatase delta http://www.genome.jp/dbget-bin/www_bget?ko:K06777 P16621 1339 2.3e-146 Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49122 BP_3 67.75 2.66 1518 795021508 XP_011860288.1 1161 2.3e-124 PREDICTED: putative uncharacterized protein FLJ37770 [Vollenhovia emeryi] 795018260 XM_012003757.1 984 0 PREDICTED: Vollenhovia emeryi putative uncharacterized protein FLJ37770 (LOC105556663), mRNA -- -- -- -- Q7JQ07 340 1.5e-30 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF07778 Mis6 GO:0034508 centromere complex assembly -- -- GO:0000776 kinetochore -- -- Cluster-8309.49125 BP_3 110.92 1.75 3345 642934172 XP_969292.2 1255 6.5e-135 PREDICTED: ras-related protein Rab-3 isoform X1 [Tribolium castaneum] 242004796 XM_002423218.1 218 9.89098e-108 Pediculus humanus corporis RAB 3 and, putative, mRNA K07883 RAB3C Ras-related protein Rab-3C http://www.genome.jp/dbget-bin/www_bget?ko:K07883 P25228 1074 2.6e-115 Ras-related protein Rab-3 OS=Drosophila melanogaster GN=Rab3 PE=1 SV=1 PF04451//PF03193//PF04670//PF00071//PF00503//PF01926//PF08477//PF00025//PF02421 Large eukaryotic DNA virus major capsid protein//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0007165//GO:0007264//GO:0015684//GO:0007186 signal transduction//small GTPase mediated signal transduction//ferrous iron transport//G-protein coupled receptor signaling pathway GO:0005198//GO:0003924//GO:0015093//GO:0031683//GO:0005525//GO:0019001//GO:0004871 structural molecule activity//GTPase activity//ferrous iron transmembrane transporter activity//G-protein beta/gamma-subunit complex binding//GTP binding//guanyl nucleotide binding//signal transducer activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.4913 BP_3 1.00 4.57 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49131 BP_3 759.12 10.05 3931 642910295 XP_008200272.1 1711 1.0e-187 PREDICTED: beta-N-acetylglucosaminidase NAG2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00827 AGXT2 alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00827 Q9BYV1 1306 3.8e-142 Alanine--glyoxylate aminotransferase 2, mitochondrial OS=Homo sapiens GN=AGXT2 PE=1 SV=1 PF00728//PF00202//PF00155 Glycosyl hydrolase family 20, catalytic domain//Aminotransferase class-III//Aminotransferase class I and II GO:0009058//GO:0005975 biosynthetic process//carbohydrate metabolic process GO:0030170//GO:0008483//GO:0004553 pyridoxal phosphate binding//transaminase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.49132 BP_3 70.49 0.96 3841 642910295 XP_008200272.1 1711 9.9e-188 PREDICTED: beta-N-acetylglucosaminidase NAG2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00827 AGXT2 alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00827 Q9BYV1 1267 1.2e-137 Alanine--glyoxylate aminotransferase 2, mitochondrial OS=Homo sapiens GN=AGXT2 PE=1 SV=1 PF00155//PF00202//PF00728 Aminotransferase class I and II//Aminotransferase class-III//Glycosyl hydrolase family 20, catalytic domain GO:0005975//GO:0009058 carbohydrate metabolic process//biosynthetic process GO:0004553//GO:0008483//GO:0030170 hydrolase activity, hydrolyzing O-glycosyl compounds//transaminase activity//pyridoxal phosphate binding -- -- KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.49133 BP_3 8.14 0.49 1088 642939406 XP_008193285.1 270 3.5e-21 PREDICTED: uncharacterized protein LOC661130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82596 143 7.6e-08 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49136 BP_3 842.84 14.99 3002 642921429 XP_974248.2 1678 5.2e-184 PREDICTED: uncharacterized protein LOC663094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4KMD7 284 9.4e-24 Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Danio rerio GN=tut1 PE=2 SV=1 PF01909//PF08039//PF09128 Nucleotidyltransferase domain//Mitochondrial proteolipid//Regulator of G protein signalling-like domain GO:0043087 regulation of GTPase activity GO:0005089//GO:0016779 Rho guanyl-nucleotide exchange factor activity//nucleotidyltransferase activity GO:0005737//GO:0005739 cytoplasm//mitochondrion KOG2277 S-M checkpoint control protein CID1 and related nucleotidyltransferases Cluster-8309.49137 BP_3 8.00 0.58 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49138 BP_3 206.63 2.25 4717 478260065 ENN79850.1 406 2.6e-36 hypothetical protein YQE_03670, partial [Dendroctonus ponderosae]>gi|546676798|gb|ERL87744.1| hypothetical protein D910_05133, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0030431//GO:1903818//GO:0032222//GO:0007178//GO:0016310//GO:0009069 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic//transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.4914 BP_3 6.00 3.86 363 795009010 XP_011859826.1 294 1.9e-24 PREDICTED: uncharacterized protein LOC105557250, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07531 NHR1 homology to TAF GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.49140 BP_3 77.37 0.88 4509 478260065 ENN79850.1 406 2.4e-36 hypothetical protein YQE_03670, partial [Dendroctonus ponderosae]>gi|546676798|gb|ERL87744.1| hypothetical protein D910_05133, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:1903818//GO:0030431//GO:0032222//GO:0016310//GO:0009069//GO:0007178 positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic//phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.49142 BP_3 63.30 2.09 1750 546673729 ERL85285.1 1122 9.0e-120 hypothetical protein D910_02706 [Dendroctonus ponderosae] -- -- -- -- -- K10812 GlcAT-SP beta-1,3-glucuronyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10812 Q9VTG7 854 4.4e-90 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P OS=Drosophila melanogaster GN=GlcAT-P PE=2 SV=1 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.49144 BP_3 564.09 16.43 1947 546673062 ERL84739.1 956 1.8e-100 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 451 2.6e-43 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF02230//PF07859//PF10503//PF01764//PF11112//PF03583 Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Esterase PHB depolymerase//Lipase (class 3)//Pyocin activator protein PrtN//Secretory lipase GO:0008152//GO:0006629//GO:0016042//GO:0006355//GO:0046486 metabolic process//lipid metabolic process//lipid catabolic process//regulation of transcription, DNA-templated//glycerolipid metabolic process GO:0016787//GO:0004806 hydrolase activity//triglyceride lipase activity GO:0005576 extracellular region KOG1552 Predicted alpha/beta hydrolase Cluster-8309.49145 BP_3 67.02 1.91 1985 546673062 ERL84739.1 806 4.5e-83 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 361 7.3e-33 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF11112//PF01764//PF07859//PF10503 Pyocin activator protein PrtN//Lipase (class 3)//alpha/beta hydrolase fold//Esterase PHB depolymerase GO:0008152//GO:0006355//GO:0006629 metabolic process//regulation of transcription, DNA-templated//lipid metabolic process GO:0016787 hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.49147 BP_3 204.31 1.75 5920 189239140 XP_001806913.1 1267 4.7e-136 PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|642928372|ref|XP_008192716.1| PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|270010787|gb|EFA07235.1| hypothetical protein TcasGA2_TC010592 [Tribolium castaneum] 657809175 XM_008333639.1 51 1.20227e-14 PREDICTED: Cynoglossus semilaevis TSC22 domain family protein 2-like (LOC103395840), transcript variant X2, mRNA -- -- -- -- Q24523 204 3.5e-14 Protein bunched, class 2/F/G isoform OS=Drosophila melanogaster GN=bun PE=2 SV=4 PF06005//PF00170//PF01486//PF04977//PF06156//PF07716//PF00038//PF11365//PF04799//PF07926//PF01166 Protein of unknown function (DUF904)//bZIP transcription factor//K-box region//Septum formation initiator//Protein of unknown function (DUF972)//Basic region leucine zipper//Intermediate filament protein//Protein of unknown function (DUF3166)//fzo-like conserved region//TPR/MLP1/MLP2-like protein//TSC-22/dip/bun family GO:0010506//GO:0006606//GO:0006355//GO:0006260//GO:0007049//GO:0008053//GO:0000917//GO:0043093 regulation of autophagy//protein import into nucleus//regulation of transcription, DNA-templated//DNA replication//cell cycle//mitochondrial fusion//barrier septum assembly//FtsZ-dependent cytokinesis GO:0005198//GO:0003924//GO:0043565//GO:0003700 structural molecule activity//GTPase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005882//GO:0005615//GO:0005737//GO:0005634//GO:0005667//GO:0005741 integral component of membrane//intermediate filament//extracellular space//cytoplasm//nucleus//transcription factor complex//mitochondrial outer membrane KOG4797 Transcriptional regulator Cluster-8309.49149 BP_3 96.05 5.72 1101 642919346 XP_008191834.1 536 5.0e-52 PREDICTED: uncharacterized protein LOC662079 [Tribolium castaneum]>gi|270005802|gb|EFA02250.1| hypothetical protein TcasGA2_TC007913 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690//PF05425 Major Facilitator Superfamily//Copper resistance protein D GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.4915 BP_3 15.00 1.74 707 795008352 XP_011883559.1 369 7.5e-33 PREDICTED: uncharacterized protein LOC105570729 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49151 BP_3 105.62 0.83 6450 91077834 XP_971265.1 6215 0.0e+00 PREDICTED: integrator complex subunit 1 [Tribolium castaneum]>gi|270002256|gb|EEZ98703.1| hypothetical protein TcasGA2_TC001242 [Tribolium castaneum] -- -- -- -- -- K13138 INTS1 integrator complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13138 Q6P4S8 2069 2.1e-230 Integrator complex subunit 1 OS=Mus musculus GN=Ints1 PE=2 SV=2 PF01602//PF04443//PF02985 Adaptin N terminal region//Acyl-protein synthetase, LuxE//HEAT repeat GO:0016192//GO:0006886//GO:0008218 vesicle-mediated transport//intracellular protein transport//bioluminescence GO:0047474//GO:0005515 long-chain fatty acid luciferin component ligase activity//protein binding GO:0030117 membrane coat -- -- Cluster-8309.49152 BP_3 720.94 5.65 6437 91077834 XP_971265.1 7175 0.0e+00 PREDICTED: integrator complex subunit 1 [Tribolium castaneum]>gi|270002256|gb|EEZ98703.1| hypothetical protein TcasGA2_TC001242 [Tribolium castaneum] -- -- -- -- -- K13138 INTS1 integrator complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13138 Q6P4S8 2384 6.2e-267 Integrator complex subunit 1 OS=Mus musculus GN=Ints1 PE=2 SV=2 PF04443 Acyl-protein synthetase, LuxE GO:0008218 bioluminescence GO:0047474 long-chain fatty acid luciferin component ligase activity -- -- -- -- Cluster-8309.49154 BP_3 90.25 2.17 2292 91090216 XP_968004.1 1600 4.4e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.7e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008146//GO:0008476 sulfotransferase activity//protein-tyrosine sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.49155 BP_3 371.89 15.57 1443 642922884 XP_008200437.1 1527 8.1e-167 PREDICTED: uncharacterized protein LOC659493 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49156 BP_3 48.52 0.39 6326 91094819 XP_970889.1 1558 9.0e-170 PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|642922887|ref|XP_008200438.1| PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|270006570|gb|EFA03018.1| hypothetical protein TcasGA2_TC010441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49157 BP_3 258.78 2.64 5016 642922889 XP_008200440.1 1532 7.4e-167 PREDICTED: uncharacterized protein LOC659493 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49158 BP_3 203.48 7.02 1689 91094819 XP_970889.1 1558 2.4e-170 PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|642922887|ref|XP_008200438.1| PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|270006570|gb|EFA03018.1| hypothetical protein TcasGA2_TC010441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49159 BP_3 295.33 2.83 5313 91094819 XP_970889.1 1558 7.6e-170 PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|642922887|ref|XP_008200438.1| PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|270006570|gb|EFA03018.1| hypothetical protein TcasGA2_TC010441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4916 BP_3 1.00 0.31 445 795009481 XP_011861944.1 157 1.8e-08 PREDICTED: uncharacterized protein LOC105558715, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49160 BP_3 163.83 1.87 4507 189236906 XP_001809986.1 2851 0.0e+00 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 1480 2.9e-162 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF00140//PF00023//PF13606//PF01529 Sigma-70 factor, region 1.2//Ankyrin repeat//Ankyrin repeat//DHHC palmitoyltransferase GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0005515//GO:0008270//GO:0016987//GO:0003700//GO:0046872 DNA binding//protein binding//zinc ion binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0005667 transcription factor complex KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.49161 BP_3 16.00 0.77 1293 227018332 ACP18832.1 818 1.2e-84 tetraspanin 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P08962 286 2.4e-24 CD63 antigen OS=Homo sapiens GN=CD63 PE=1 SV=2 PF00335//PF03600 Tetraspanin family//Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49165 BP_3 366.83 14.48 1513 642934075 XP_008196143.1 1076 1.7e-114 PREDICTED: sin3 histone deacetylase corepressor complex component SDS3 [Tribolium castaneum]>gi|270012950|gb|EFA09398.1| hypothetical protein TcasGA2_TC004316 [Tribolium castaneum] 347964404 XM_559379.4 34 8.51902e-06 Anopheles gambiae str. PEST AGAP000738-PA (AgaP_AGAP000738) mRNA, complete cds K19201 SUDS3, SAP45 Sin3 histone deacetylase corepressor complex component SDS3 http://www.genome.jp/dbget-bin/www_bget?ko:K19201 Q5RBB8 633 1.6e-64 Sin3 histone deacetylase corepressor complex component SDS3 OS=Pongo abelii GN=SUDS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49167 BP_3 786.07 6.72 5933 478255012 ENN75245.1 1054 2.3e-111 hypothetical protein YQE_08254, partial [Dendroctonus ponderosae] -- -- -- -- -- K10684 UBLE1A, SAE1 ubiquitin-like 1-activating enzyme E1 A http://www.genome.jp/dbget-bin/www_bget?ko:K10684 Q28DS0 490 2.4e-47 SUMO-activating enzyme subunit 1 OS=Xenopus tropicalis GN=sae1 PE=2 SV=1 PF07243//PF00899 Phlebovirus glycoprotein G1//ThiF family -- -- GO:0008641 small protein activating enzyme activity GO:0019012//GO:0016021 virion//integral component of membrane KOG2014 SMT3/SUMO-activating complex, AOS1/RAD31 component Cluster-8309.49171 BP_3 11.49 0.97 862 270003787 EFA00235.1 419 1.4e-38 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 239 4.4e-19 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49172 BP_3 79.96 1.37 3115 546679741 ERL90152.1 1446 4.3e-157 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BKN5 456 1.1e-43 Gamma-tubulin complex component 5 OS=Mus musculus GN=Tubgcp5 PE=2 SV=2 PF04505//PF04130 Interferon-induced transmembrane protein//Spc97 / Spc98 family GO:0009607//GO:0090063//GO:0000226 response to biotic stimulus//positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0000922//GO:0005815//GO:0016021 spindle pole//microtubule organizing center//integral component of membrane -- -- Cluster-8309.49174 BP_3 44.20 0.51 4487 642927980 XP_008195470.1 780 1.0e-79 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AKG8 219 4.8e-16 Focadhesin OS=Mus musculus GN=Focad PE=2 SV=1 PF01105//PF00514 emp24/gp25L/p24 family/GOLD//Armadillo/beta-catenin-like repeat GO:0006810 transport GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.49175 BP_3 54.75 2.39 1398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49176 BP_3 17.00 3.45 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49177 BP_3 5.00 2.43 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49178 BP_3 14.74 0.59 1498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49179 BP_3 91.00 9.57 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49180 BP_3 55.01 2.35 1419 270016115 EFA12563.1 267 1.0e-20 hypothetical protein TcasGA2_TC004192 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845//PF09009 CUE domain//Exotoxin A catalytic -- -- GO:0047286//GO:0005515 NAD+-diphthamide ADP-ribosyltransferase activity//protein binding -- -- -- -- Cluster-8309.49182 BP_3 25.00 4.07 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49183 BP_3 31.59 1.13 1634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02388 FemAB family GO:0009252 peptidoglycan biosynthetic process GO:0016755 transferase activity, transferring amino-acyl groups -- -- -- -- Cluster-8309.49184 BP_3 23.99 1.93 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49185 BP_3 76.70 1.54 2692 642917000 XP_008199589.1 413 2.3e-37 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 153 1.3e-08 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.49186 BP_3 194.19 4.03 2614 642917000 XP_008199589.1 426 6.8e-39 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 153 1.3e-08 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.49187 BP_3 25.61 1.75 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49188 BP_3 214.60 6.98 1773 642923014 XP_008200496.1 897 1.1e-93 PREDICTED: transcription factor GATA-5-like isoform X3 [Tribolium castaneum]>gi|270008081|gb|EFA04529.1| serpent [Tribolium castaneum] 642923013 XM_008202274.1 127 2.00609e-57 PREDICTED: Tribolium castaneum transcription factor GATA-4-like (LOC661909), transcript variant X3, mRNA K17896 GATA5 GATA-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17896 P52172 304 2.7e-26 Box A-binding factor OS=Drosophila melanogaster GN=srp PE=1 SV=2 PF01873//PF08752//PF00320 Domain found in IF2B/IF5//Coatomer gamma subunit appendage platform subdomain//GATA zinc finger GO:0016192//GO:0006446//GO:0006886//GO:0006355//GO:0006413 vesicle-mediated transport//regulation of translational initiation//intracellular protein transport//regulation of transcription, DNA-templated//translational initiation GO:0005198//GO:0003743//GO:0003700//GO:0008270//GO:0043565 structural molecule activity//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005840//GO:0030126 transcription factor complex//ribosome//COPI vesicle coat KOG1601 GATA-4/5/6 transcription factors Cluster-8309.49191 BP_3 844.39 23.81 2001 642936656 XP_008198526.1 629 1.5e-62 PREDICTED: LOW QUALITY PROTEIN: probable nuclear transport factor 2 [Tribolium castaneum] 642936655 XM_008200304.1 162 7.93397e-77 PREDICTED: Tribolium castaneum nuclear transport factor-2 (LOC662356), mRNA -- -- -- -- Q21735 305 2.3e-26 Probable nuclear transport factor 2 OS=Caenorhabditis elegans GN=ran-4 PE=3 SV=1 PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular KOG2104 Nuclear transport factor 2 Cluster-8309.49192 BP_3 606.62 7.62 4127 91089273 XP_966340.1 958 2.2e-100 PREDICTED: autophagy-related protein 101 [Tribolium castaneum]>gi|270011443|gb|EFA07891.1| hypothetical protein TcasGA2_TC005466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH75 708 8.8e-73 Autophagy-related protein 101 OS=Xenopus tropicalis GN=atg101 PE=2 SV=1 PF00069//PF06293//PF07714//PF02907 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Hepatitis C virus NS3 protease GO:0006468//GO:0006508//GO:0019087 protein phosphorylation//proteolysis//transformation of host cell by virus GO:0005524//GO:0016773//GO:0004672//GO:0008236 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//serine-type peptidase activity GO:0016020 membrane KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.49197 BP_3 70.53 1.17 3190 270003145 EEZ99592.1 4002 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.3e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1094 Discoidin domain receptor DDR1 Cluster-8309.49198 BP_3 26.15 0.67 2173 642917574 XP_008191263.1 651 4.6e-65 PREDICTED: zinc transporter ZIP11 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14717 SLC39A11, ZIP11 solute carrier family 39 (zinc transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14717 Q8N1S5 479 1.7e-46 Zinc transporter ZIP11 OS=Homo sapiens GN=SLC39A11 PE=2 SV=3 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2474 Zinc transporter and related ZIP domain-containing proteins Cluster-8309.49199 BP_3 103.39 1.89 2931 642917574 XP_008191263.1 1239 4.1e-133 PREDICTED: zinc transporter ZIP11 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14717 SLC39A11, ZIP11 solute carrier family 39 (zinc transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14717 Q8BWY7 763 2.6e-79 Zinc transporter ZIP11 OS=Mus musculus GN=Slc39a11 PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2474 Zinc transporter and related ZIP domain-containing proteins Cluster-8309.49202 BP_3 65.48 0.62 5370 642915700 XP_008190765.1 2741 5.1e-307 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X3 [Tribolium castaneum] 642915699 XM_008192543.1 576 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 759 1.4e-78 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.49203 BP_3 2.00 0.64 443 270007560 EFA04008.1 161 6.1e-09 hypothetical protein TcasGA2_TC014157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49205 BP_3 389.78 17.70 1353 478258160 ENN78298.1 1380 8.4e-150 hypothetical protein YQE_05448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZV5 975 3.2e-104 Cysteine and histidine-rich protein 1 homolog OS=Drosophila melanogaster GN=CG32486 PE=2 SV=2 PF03145//PF00097//PF02176//PF13639 Seven in absentia protein family//Zinc finger, C3HC4 type (RING finger)//TRAF-type zinc finger//Ring finger domain GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.49207 BP_3 19.61 0.56 1991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49209 BP_3 11.03 0.98 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49210 BP_3 1474.87 28.25 2808 189234759 XP_001814707.1 1633 8.0e-179 PREDICTED: SET and MYND domain-containing protein 5 [Tribolium castaneum]>gi|270001538|gb|EEZ97985.1| hypothetical protein TcasGA2_TC000380 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GPQ4 1083 2.0e-116 SET and MYND domain-containing protein 5 OS=Xenopus laevis GN=smyd5 PE=2 SV=1 PF07966//PF00856//PF04636//PF05279 A1 Propeptide//SET domain//PA26 p53-induced protein (sestrin)//Aspartyl beta-hydroxylase N-terminal region GO:1901031//GO:0006508 regulation of response to reactive oxygen species//proteolysis GO:0005515//GO:0004190 protein binding//aspartic-type endopeptidase activity GO:0016020//GO:0005634 membrane//nucleus KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.49212 BP_3 60.27 1.88 1834 642939503 XP_008190892.1 958 9.8e-101 PREDICTED: protein shifted isoform X1 [Tribolium castaneum]>gi|642939505|ref|XP_008190898.1| PREDICTED: protein shifted isoform X1 [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 637 6.7e-65 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.49213 BP_3 46.06 0.58 4150 642912878 XP_971323.2 658 1.4e-65 PREDICTED: EP300-interacting inhibitor of differentiation 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXX6 190 1.0e-12 Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens GN=NSMCE4A PE=1 SV=2 PF01405//PF00790//PF15050 Photosystem II reaction centre T protein//VHS domain//SCIMP protein GO:0015979//GO:0006886 photosynthesis//intracellular protein transport -- -- GO:0001772//GO:0016021//GO:0097197//GO:0016020//GO:0009523//GO:0009539 immunological synapse//integral component of membrane//tetraspanin-enriched microdomain//membrane//photosystem II//photosystem II reaction center KOG2866 Uncharacterized conserved protein Cluster-8309.49214 BP_3 396.16 3.69 5462 642915644 XP_972006.3 3143 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.3e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.49217 BP_3 203.49 2.54 4156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49218 BP_3 63.37 0.51 6227 612026501 XP_007492212.1 603 4.8e-59 PREDICTED: zinc finger protein 91-like [Monodelphis domestica] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NYT6 585 2.4e-58 Zinc finger protein 226 OS=Homo sapiens GN=ZNF226 PE=2 SV=2 PF02053//PF00130//PF13465//PF00096//PF13912 Gene 66 (IR5) protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger GO:0035556 intracellular signal transduction GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.49219 BP_3 353.88 5.35 3477 91090880 XP_973129.1 851 4.7e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.4e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.49220 BP_3 716.06 33.89 1310 91087023 XP_974255.1 1422 1.1e-154 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q9C0D9 802 3.5e-84 Ethanolaminephosphotransferase 1 OS=Homo sapiens GN=EPT1 PE=1 SV=3 PF01066//PF13292 CDP-alcohol phosphatidyltransferase//1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694//GO:0008654 terpenoid biosynthetic process//steroid biosynthetic process//phospholipid biosynthetic process GO:0008661//GO:0016780 1-deoxy-D-xylulose-5-phosphate synthase activity//phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.49221 BP_3 25.04 1.17 1322 270001008 EEZ97455.1 390 5.1e-35 hypothetical protein TcasGA2_TC011286 [Tribolium castaneum] -- -- -- -- -- K05527 bolA BolA protein http://www.genome.jp/dbget-bin/www_bget?ko:K05527 Q86KD0 282 7.0e-24 BolA-like protein DDB_G0274169 OS=Dictyostelium discoideum GN=DDB_G0274169 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2313 Stress-induced protein UVI31+ Cluster-8309.49222 BP_3 281.45 5.78 2640 820805518 AKG92750.1 2539 6.6e-284 tango [Leptinotarsa decemlineata] 820805517 KP147913.1 351 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1775 1.1e-196 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF00989//PF08447//PF00010 PAS fold//PAS fold//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.49223 BP_3 56.02 1.13 2673 642914766 XP_008190343.1 639 1.4e-63 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 329 5.1e-29 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.49224 BP_3 31.91 3.01 803 642932946 XP_008197199.1 581 2.2e-57 PREDICTED: sodium-independent sulfate anion transporter-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q58DD2 349 7.3e-32 Sodium-independent sulfate anion transporter OS=Bos taurus GN=SLC26A11 PE=2 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49226 BP_3 10.38 0.46 1373 270012481 EFA08929.1 901 3.0e-94 hypothetical protein TcasGA2_TC006636 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 576 5.9e-58 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.49228 BP_3 416.98 15.10 1623 642928571 XP_008199962.1 975 9.2e-103 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q16MW6 940 4.3e-100 S-methyl-5'-thioadenosine phosphorylase OS=Aedes aegypti GN=AAEL012172 PE=3 SV=1 PF01048//PF12422 Phosphorylase superfamily//Condensin II non structural maintenance of chromosomes subunit GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity GO:0005634 nucleus KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.49229 BP_3 37.84 0.45 4321 642924318 XP_008194246.1 944 9.7e-99 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 374 5.0e-34 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 -- -- GO:0006820//GO:0006821 anion transport//chloride transport GO:0005254 chloride channel activity GO:0034707 chloride channel complex -- -- Cluster-8309.49233 BP_3 204.36 1.57 6573 91077990 XP_968879.1 2384 1.5e-265 PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp3 [Tribolium castaneum]>gi|270001423|gb|EEZ97870.1| hypothetical protein TcasGA2_TC000245 [Tribolium castaneum] 642914786 XM_008192130.1 262 6.78036e-132 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X7, mRNA K12843 PRPF3, PRP3 U4/U6 small nuclear ribonucleoprotein PRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K12843 Q922U1 1295 1.2e-140 U4/U6 small nuclear ribonucleoprotein Prp3 OS=Mus musculus GN=Prpf3 PE=2 SV=1 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2769 Putative u4/u6 small nuclear ribonucleoprotein Cluster-8309.49234 BP_3 27.00 0.55 2665 591326172 XP_007089078.1 181 1.8e-10 PREDICTED: zinc finger protein 658-like isoform X1 [Panthera tigris altaica]>gi|591326174|ref|XP_007089079.1| PREDICTED: zinc finger protein 658-like isoform X2 [Panthera tigris altaica] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q4V348 178 1.6e-11 Zinc finger protein 658B OS=Homo sapiens GN=ZNF658B PE=2 SV=1 PF13912//PF00651//PF13465//PF02178//PF00096 C2H2-type zinc finger//BTB/POZ domain//Zinc-finger double domain//AT hook motif//Zinc finger, C2H2 type -- -- GO:0003677//GO:0005515//GO:0046872 DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.49235 BP_3 2027.87 20.31 5105 642924872 XP_008194077.1 631 2.3e-62 PREDICTED: tubulin glycylase 3A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM92 435 4.9e-41 Tubulin glycylase 3B OS=Drosophila melanogaster GN=TTLL3B PE=1 SV=2 PF06156//PF04111//PF03194//PF03255//PF02601//PF03133 Protein of unknown function (DUF972)//Autophagy protein Apg6//LUC7 N_terminus//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Exonuclease VII, large subunit//Tubulin-tyrosine ligase family GO:0006376//GO:0006464//GO:0006633//GO:0006914//GO:0006090//GO:0006260//GO:0006308 mRNA splice site selection//cellular protein modification process//fatty acid biosynthetic process//autophagy//pyruvate metabolic process//DNA replication//DNA catabolic process GO:0008855//GO:0003989//GO:0003729 exodeoxyribonuclease VII activity//acetyl-CoA carboxylase activity//mRNA binding GO:0005685//GO:0009318//GO:0009317 U1 snRNP//exodeoxyribonuclease VII complex//acetyl-CoA carboxylase complex KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.49236 BP_3 272.10 4.46 3232 642924872 XP_008194077.1 631 1.4e-62 PREDICTED: tubulin glycylase 3A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM92 435 3.1e-41 Tubulin glycylase 3B OS=Drosophila melanogaster GN=TTLL3B PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.49239 BP_3 217.24 0.70 15260 642914247 XP_008201606.1 19171 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10506 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF00028//PF08717//PF00008//PF07645 Cadherin domain//nsp8 replicase//EGF-like domain//Calcium-binding EGF domain GO:0007156//GO:0006508 homophilic cell adhesion via plasma membrane adhesion molecules//proteolysis GO:0008242//GO:0016740//GO:0005515//GO:0005509//GO:0004197 omega peptidase activity//transferase activity//protein binding//calcium ion binding//cysteine-type endopeptidase activity GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.49240 BP_3 377.62 1.30 14346 189241098 XP_971301.2 13697 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13D [Tribolium castaneum] -- -- -- -- -- K19527 VPS13D vacuolar protein sorting-associated protein 13D http://www.genome.jp/dbget-bin/www_bget?ko:K19527 Q5THJ4 2751 3.9e-309 Vacuolar protein sorting-associated protein 13D OS=Homo sapiens GN=VPS13D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.49241 BP_3 113.68 1.45 4082 478253469 ENN73796.1 2068 4.2e-229 hypothetical protein YQE_09574, partial [Dendroctonus ponderosae] -- -- -- -- -- K08863 PLK4 polo-like kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08863 A2VDZ4 1218 6.3e-132 Serine/threonine-protein kinase PLK4 OS=Bos taurus GN=PLK4 PE=2 SV=1 PF07714//PF00069//PF00050//PF06293//PF07648 Protein tyrosine kinase//Protein kinase domain//Kazal-type serine protease inhibitor domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Kazal-type serine protease inhibitor domain GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524//GO:0016773 protein kinase activity//protein binding//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0575 Polo-like serine/threonine protein kinase Cluster-8309.49245 BP_3 568.53 5.22 5539 546675155 ERL86391.1 1444 1.3e-156 hypothetical protein D910_03799 [Dendroctonus ponderosae] -- -- -- -- -- K14859 SSF1_2 ribosome biogenesis protein SSF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14859 Q9VDE5 984 1.2e-104 Protein Peter pan OS=Drosophila melanogaster GN=ppan PE=1 SV=1 PF02086//PF14721//PF13414//PF00515//PF03602//PF13371//PF01555//PF02384//PF13181//PF08241//PF14863//PF05944 D12 class N6 adenine-specific DNA methyltransferase//Apoptosis-inducing factor, mitochondrion-associated, C-term//TPR repeat//Tetratricopeptide repeat//Conserved hypothetical protein 95//Tetratricopeptide repeat//DNA methylase//N-6 DNA Methylase//Tetratricopeptide repeat//Methyltransferase domain//Alkyl sulfatase dimerisation//Phage small terminase subunit GO:0031167//GO:0032775//GO:0008152//GO:0006306//GO:0019069 rRNA methylation//DNA methylation on adenine//metabolic process//DNA methylation//viral capsid assembly GO:0005515//GO:0046983//GO:0003677//GO:0004519//GO:0009007//GO:0008170//GO:0008168 protein binding//protein dimerization activity//DNA binding//endonuclease activity//site-specific DNA-methyltransferase (adenine-specific) activity//N-methyltransferase activity//methyltransferase activity -- -- KOG2963 RNA-binding protein required for 60S ribosomal subunit biogenesis Cluster-8309.49246 BP_3 748.13 4.82 7771 642914403 XP_008201481.1 2818 0.0e+00 PREDICTED: TELO2-interacting protein 1 homolog [Tribolium castaneum] 780665329 XM_011695591.1 121 1.93114e-53 PREDICTED: Wasmannia auropunctata uncharacterized LOC105453540 (LOC105453540), mRNA -- -- -- -- Q9BY31 411 4.6e-38 Zinc finger protein 717 OS=Homo sapiens GN=ZNF717 PE=2 SV=2 PF14634//PF00628//PF16866//PF00569//PF00096//PF13912//PF00412//PF05191//PF01428//PF08064//PF13465//PF07975 zinc-RING finger domain//PHD-finger//PHD-finger//Zinc finger, ZZ type//Zinc finger, C2H2 type//C2H2-type zinc finger//LIM domain//Adenylate kinase, active site lid//AN1-like Zinc finger//UME (NUC010) domain//Zinc-finger double domain//TFIIH C1-like domain GO:0016310//GO:0006281//GO:0009069//GO:0006144//GO:0046034 phosphorylation//DNA repair//serine family amino acid metabolic process//purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0046872//GO:0004674//GO:0004017//GO:0005515 zinc ion binding//metal ion binding//protein serine/threonine kinase activity//adenylate kinase activity//protein binding -- -- -- -- Cluster-8309.49248 BP_3 31.69 0.54 3133 91084345 XP_972963.1 1879 2.7e-207 PREDICTED: SH2B adapter protein 2 isoform X1 [Tribolium castaneum]>gi|270008825|gb|EFA05273.1| hypothetical protein TcasGA2_TC015430 [Tribolium castaneum] -- -- -- -- -- K12459 SH2B1_3 SH2B adaptor protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12459 Q9UQQ2 476 5.3e-46 SH2B adapter protein 3 OS=Homo sapiens GN=SH2B3 PE=1 SV=2 PF00583//PF13508//PF08916//PF01395 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Phenylalanine zipper//PBP/GOBP family GO:0007165//GO:0042967//GO:0035556 signal transduction//acyl-carrier-protein biosynthetic process//intracellular signal transduction GO:0005549//GO:0005543//GO:0008080//GO:0004871 odorant binding//phospholipid binding//N-acetyltransferase activity//signal transducer activity GO:0005622 intracellular -- -- Cluster-8309.49249 BP_3 262.90 1.49 8816 91081101 XP_975504.1 3888 0.0e+00 PREDICTED: DNA topoisomerase 3-beta-1 [Tribolium castaneum]>gi|270005298|gb|EFA01746.1| hypothetical protein TcasGA2_TC007344 [Tribolium castaneum] -- -- -- -- -- K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 O95985 2923 0.0e+00 DNA topoisomerase 3-beta-1 OS=Homo sapiens GN=TOP3B PE=1 SV=1 PF04421//PF13855//PF00560//PF01131 Mss4 protein//Leucine rich repeat//Leucine Rich Repeat//DNA topoisomerase GO:0006265//GO:0007264//GO:0043087 DNA topological change//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005515//GO:0003916//GO:0003677//GO:0003917//GO:0005085 protein binding//DNA topoisomerase activity//DNA binding//DNA topoisomerase type I activity//guanyl-nucleotide exchange factor activity GO:0005694 chromosome KOG1956 DNA topoisomerase III alpha Cluster-8309.4925 BP_3 120.00 6.30 1210 662192401 XP_008469056.1 154 1.1e-07 PREDICTED: uncharacterized protein LOC103506445 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.49250 BP_3 1037.63 6.25 8296 91081101 XP_975504.1 3888 0.0e+00 PREDICTED: DNA topoisomerase 3-beta-1 [Tribolium castaneum]>gi|270005298|gb|EFA01746.1| hypothetical protein TcasGA2_TC007344 [Tribolium castaneum] -- -- -- -- -- K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 O95985 2923 0.0e+00 DNA topoisomerase 3-beta-1 OS=Homo sapiens GN=TOP3B PE=1 SV=1 PF00560//PF01131//PF04421//PF13855 Leucine Rich Repeat//DNA topoisomerase//Mss4 protein//Leucine rich repeat GO:0043087//GO:0006265//GO:0007264 regulation of GTPase activity//DNA topological change//small GTPase mediated signal transduction GO:0003917//GO:0003677//GO:0005085//GO:0005515//GO:0003916 DNA topoisomerase type I activity//DNA binding//guanyl-nucleotide exchange factor activity//protein binding//DNA topoisomerase activity GO:0005694 chromosome KOG1956 DNA topoisomerase III alpha Cluster-8309.49252 BP_3 22.77 3.04 653 642911734 XP_008200718.1 540 1.0e-52 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC660336 [Tribolium castaneum] 768412001 XM_011568499.1 42 1.27458e-10 PREDICTED: Plutella xylostella serine/arginine repetitive matrix protein 1 (LOC105396496), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49253 BP_3 15.06 0.41 2052 642911278 XP_008199353.1 1882 7.8e-208 PREDICTED: glutamate-gated chloride channel isoform X3 [Tribolium castaneum] 768428214 XM_011556933.1 327 1.54035e-168 PREDICTED: Plutella xylostella glutamate-gated chloride channel-like (LOC105386383), transcript variant X8, mRNA K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 1639 4.9e-181 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.49257 BP_3 217.00 18.74 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49259 BP_3 304.00 3.76 4190 546671782 ERL83947.1 882 1.4e-91 hypothetical protein D910_01240 [Dendroctonus ponderosae]>gi|546671784|gb|ERL83948.1| hypothetical protein D910_01241 [Dendroctonus ponderosae] 642930107 XM_008198033.1 119 1.34216e-52 PREDICTED: Tribolium castaneum probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (LOC656360), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07839 Plant calmodulin-binding domain -- -- GO:0005516 calmodulin binding -- -- -- -- Cluster-8309.49260 BP_3 327.24 2.32 7078 166998249 NP_001107795.1 2592 1.3e-289 CYCLE [Tribolium castaneum]>gi|140270864|gb|ABO86538.1| CYCLE [Tribolium castaneum] 121945612 AB289690.1 179 1.00698e-85 Dianemobius nigrofasciatus mRNA for circadian transcription modulator CYCLE, partial cds K02296 ARNTL, BMAL1, CYC aryl hydrocarbon receptor nuclear translocator-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02296 A0MLS5 1442 1.2e-157 Aryl hydrocarbon receptor nuclear translocator-like protein 1 OS=Equus caballus GN=ARNTL PE=2 SV=1 PF08447//PF08446//PF00010//PF00989//PF02159 PAS fold//PAS fold//Helix-loop-helix DNA-binding domain//PAS fold//Oestrogen receptor GO:0043401//GO:0006355//GO:0007165 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0004871//GO:0030284//GO:0005496//GO:0003700//GO:0003677//GO:0005515//GO:0046983 signal transducer activity//estrogen receptor activity//steroid binding//transcription factor activity, sequence-specific DNA binding//DNA binding//protein binding//protein dimerization activity GO:0005737//GO:0005634//GO:0005667 cytoplasm//nucleus//transcription factor complex KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.49263 BP_3 143.53 1.01 7121 166998249 NP_001107795.1 2592 1.3e-289 CYCLE [Tribolium castaneum]>gi|140270864|gb|ABO86538.1| CYCLE [Tribolium castaneum] 121945612 AB289690.1 179 1.01313e-85 Dianemobius nigrofasciatus mRNA for circadian transcription modulator CYCLE, partial cds K02296 ARNTL, BMAL1, CYC aryl hydrocarbon receptor nuclear translocator-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02296 A0MLS5 1442 1.2e-157 Aryl hydrocarbon receptor nuclear translocator-like protein 1 OS=Equus caballus GN=ARNTL PE=2 SV=1 PF00010//PF08446//PF08447//PF02159//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold//Oestrogen receptor//PAS fold GO:0007165//GO:0043401//GO:0006355 signal transduction//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005515//GO:0046983//GO:0003677//GO:0003700//GO:0004871//GO:0030284//GO:0005496 protein binding//protein dimerization activity//DNA binding//transcription factor activity, sequence-specific DNA binding//signal transducer activity//estrogen receptor activity//steroid binding GO:0005667//GO:0005634//GO:0005737 transcription factor complex//nucleus//cytoplasm KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.49266 BP_3 118.46 0.88 6795 166998249 NP_001107795.1 2587 4.6e-289 CYCLE [Tribolium castaneum]>gi|140270864|gb|ABO86538.1| CYCLE [Tribolium castaneum] 121945612 AB289690.1 179 9.66506e-86 Dianemobius nigrofasciatus mRNA for circadian transcription modulator CYCLE, partial cds K02296 ARNTL, BMAL1, CYC aryl hydrocarbon receptor nuclear translocator-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02296 A0MLS5 1442 1.1e-157 Aryl hydrocarbon receptor nuclear translocator-like protein 1 OS=Equus caballus GN=ARNTL PE=2 SV=1 PF02159//PF00989//PF08446//PF08447//PF00010 Oestrogen receptor//PAS fold//PAS fold//PAS fold//Helix-loop-helix DNA-binding domain GO:0043401//GO:0006355//GO:0007165 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0003700//GO:0004871//GO:0030284//GO:0005496//GO:0005515//GO:0046983//GO:0003677 transcription factor activity, sequence-specific DNA binding//signal transducer activity//estrogen receptor activity//steroid binding//protein binding//protein dimerization activity//DNA binding GO:0005737//GO:0005667//GO:0005634 cytoplasm//transcription factor complex//nucleus KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.49268 BP_3 11.00 0.36 1772 556756621 XP_005973660.1 651 3.7e-65 PREDICTED: choline dehydrogenase, mitochondrial-like [Pantholops hodgsonii] 697087875 XM_009658554.1 1654 0 Verticillium dahliae VdLs.17 choline dehydrogenase partial mRNA -- -- -- -- Q7X2H8 926 2.0e-98 Choline oxidase OS=Arthrobacter globiformis GN=codA PE=1 SV=1 PF01266//PF07992//PF00732//PF05834//PF05199//PF00070//PF12831 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0050660//GO:0016705//GO:0016614//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity -- -- KOG1238 Glucose dehydrogenase/choline dehydrogenase/mandelonitrile lyase (GMC oxidoreductase family) Cluster-8309.49269 BP_3 48.00 1.20 2218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05739//PF02892 SNARE domain//BED zinc finger -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.49271 BP_3 3.23 1.40 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49272 BP_3 371.90 3.41 5542 642915644 XP_972006.3 3111 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.5e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.49273 BP_3 13.00 4.68 425 765336429 XP_011493101.1 225 2.2e-16 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q804S5 174 7.5e-12 E3 ubiquitin-protein ligase mib1 OS=Danio rerio GN=mib1 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.49277 BP_3 30.22 0.55 2942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49282 BP_3 969.20 22.54 2364 478252633 ENN73038.1 1374 7.3e-149 hypothetical protein YQE_10373, partial [Dendroctonus ponderosae] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P48594 528 3.8e-52 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49287 BP_3 82.28 1.47 2997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49288 BP_3 69.11 2.06 1907 189235302 XP_001816128.1 402 3.0e-36 PREDICTED: H/ACA ribonucleoprotein complex subunit 1 [Tribolium castaneum]>gi|270003676|gb|EFA00124.1| hypothetical protein TcasGA2_TC002940 [Tribolium castaneum] 766934267 XM_011501142.1 68 1.35683e-24 PREDICTED: Ceratosolen solmsi marchali probable H/ACA ribonucleoprotein complex subunit 1 (LOC105363452), mRNA K11128 GAR1, NOLA1 H/ACA ribonucleoprotein complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11128 Q7KVQ0 330 2.8e-29 Probable H/ACA ribonucleoprotein complex subunit 1 OS=Drosophila melanogaster GN=CG4038 PE=1 SV=1 PF04410 Gar1/Naf1 RNA binding region GO:0042254//GO:0001522//GO:0031120 ribosome biogenesis//pseudouridine synthesis//snRNA pseudouridine synthesis GO:0030515//GO:0009982 snoRNA binding//pseudouridine synthase activity GO:0031429 box H/ACA snoRNP complex KOG3262 H/ACA small nucleolar RNP component GAR1 Cluster-8309.49289 BP_3 213.33 9.35 1392 339238571 XP_003380840.1 186 2.4e-11 zinc knuckle protein [Trichinella spiralis]>gi|316976211|gb|EFV59539.1| zinc knuckle protein [Trichinella spiralis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49291 BP_3 40.99 4.06 778 642915298 XP_008190560.1 882 2.7e-92 PREDICTED: JNK-interacting protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29EP6 560 2.4e-56 JNK-interacting protein 3 OS=Drosophila pseudoobscura pseudoobscura GN=syd PE=3 SV=2 PF01763//PF04977//PF06156//PF04111//PF01496//PF04508//PF10186//PF06005//PF10473//PF05837//PF17082//PF00458 Herpesvirus UL6 like//Septum formation initiator//Protein of unknown function (DUF972)//Autophagy protein Apg6//V-type ATPase 116kDa subunit family//Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14//Protein of unknown function (DUF904)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centromere protein H (CENP-H)//Spindle Pole Component 29//WHEP-TRS domain GO:0006418//GO:0000917//GO:0043093//GO:0016032//GO:0015991//GO:0030474//GO:0006260//GO:0007049//GO:0006323//GO:0010508//GO:0015992//GO:0051382//GO:0006914 tRNA aminoacylation for protein translation//barrier septum assembly//FtsZ-dependent cytokinesis//viral process//ATP hydrolysis coupled proton transport//spindle pole body duplication//DNA replication//cell cycle//DNA packaging//positive regulation of autophagy//proton transport//kinetochore assembly//autophagy GO:0042803//GO:0015078//GO:0005200//GO:0004812//GO:0005524//GO:0008134//GO:0045502 protein homodimerization activity//hydrogen ion transmembrane transporter activity//structural constituent of cytoskeleton//aminoacyl-tRNA ligase activity//ATP binding//transcription factor binding//dynein binding GO:0000776//GO:0033179//GO:0005856//GO:0030286//GO:0005667//GO:0005823//GO:0005737 kinetochore//proton-transporting V-type ATPase, V0 domain//cytoskeleton//dynein complex//transcription factor complex//central plaque of spindle pole body//cytoplasm KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.49293 BP_3 25.03 1.88 932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49295 BP_3 9.00 0.58 1043 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49296 BP_3 2.99 0.69 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49298 BP_3 113.90 0.77 7427 642927006 XP_008195101.1 3735 0.0e+00 PREDICTED: protein disabled isoform X4 [Tribolium castaneum] -- -- -- -- -- K12475 DAB2 disabled homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12475 P98081 681 2.1e-69 Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 PF07415//PF00640//PF14719 Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID) GO:0019042 viral latency GO:0005515 protein binding GO:0033644 host cell membrane KOG3535 Adaptor protein Disabled Cluster-8309.49299 BP_3 68.66 1.41 2639 642912479 XP_008200881.1 1779 8.9e-196 PREDICTED: synaptic vesicular amine transporter [Tribolium castaneum]>gi|642912481|ref|XP_008200882.1| PREDICTED: synaptic vesicular amine transporter [Tribolium castaneum] -- -- -- -- -- K08155 SLC18A1_2, VMAT MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08155 Q8BRU6 1053 5.6e-113 Synaptic vesicular amine transporter OS=Mus musculus GN=Slc18a2 PE=1 SV=1 PF07690//PF00083//PF02892 Major Facilitator Superfamily//Sugar (and other) transporter//BED zinc finger GO:0055085 transmembrane transport GO:0003677//GO:0022857 DNA binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.49301 BP_3 25.11 0.44 3040 642921918 XP_008192944.1 1544 1.8e-168 PREDICTED: zinc finger MYND domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15326 593 1.4e-59 Zinc finger MYND domain-containing protein 11 OS=Homo sapiens GN=ZMYND11 PE=1 SV=2 PF00628//PF00130//PF00439 PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.49303 BP_3 387.00 9.97 2162 642939069 XP_008200209.1 1427 4.8e-155 PREDICTED: HIV Tat-specific factor 1 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K13093 HTATSF1 HIV Tat-specific factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13093 Q5RB63 749 8.1e-78 HIV Tat-specific factor 1 homolog OS=Pongo abelii GN=HTATSF1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1548 Transcription elongation factor TAT-SF1 Cluster-8309.49307 BP_3 9.17 2.68 456 642910556 XP_008200264.1 766 4.4e-79 PREDICTED: ras-related protein Rab6 isoform X1 [Tribolium castaneum] 721611937 XM_010239811.1 71 6.59389e-27 PREDICTED: Brachypodium distachyon ras-related protein RABH1b (LOC100823113), mRNA K07893 RAB6A Ras-related protein Rab-6A http://www.genome.jp/dbget-bin/www_bget?ko:K07893 O18334 713 2.5e-74 Ras-related protein Rab6 OS=Drosophila melanogaster GN=Rab6 PE=1 SV=1 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily Cluster-8309.49308 BP_3 554.71 7.43 3890 546680213 ERL90536.1 630 2.2e-62 hypothetical protein D910_07884 [Dendroctonus ponderosae] -- -- -- -- -- K12887 HNRNPM heterogeneous nuclear ribonucleoprotein M http://www.genome.jp/dbget-bin/www_bget?ko:K12887 Q9D0E1 281 2.7e-23 Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus GN=Hnrnpm PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4212 RNA-binding protein hnRNP-M Cluster-8309.49309 BP_3 16.55 3.24 538 642915807 XP_008200086.1 414 3.4e-38 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 766926462 XM_011496875.1 94 1.28667e-39 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- O94967 258 1.7e-21 WD repeat-containing protein 47 OS=Homo sapiens GN=WDR47 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.4931 BP_3 2.00 0.35 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49311 BP_3 229.60 7.33 1802 332373366 AEE61824.1 1600 3.4e-175 unknown [Dendroctonus ponderosae]>gi|478258142|gb|ENN78280.1| hypothetical protein YQE_05431, partial [Dendroctonus ponderosae] 391342831 XM_003745671.1 69 3.56089e-25 PREDICTED: Metaseiulus occidentalis GMP reductase 2-like (LOC100902322), mRNA K00364 E1.7.1.7, guaC GMP reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00364 Q9DCZ1 1399 2.9e-153 GMP reductase 1 OS=Mus musculus GN=Gmpr PE=2 SV=1 PF01081//PF00478//PF01070 KDPG and KHG aldolase//IMP dehydrogenase / GMP reductase domain//FMN-dependent dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016829//GO:0016491//GO:0003824 lyase activity//oxidoreductase activity//catalytic activity -- -- KOG2550 IMP dehydrogenase/GMP reductase Cluster-8309.49316 BP_3 23.00 1.43 1069 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49317 BP_3 24.60 0.80 1779 641664992 XP_008183213.1 994 6.3e-105 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 923 4.5e-98 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF16622//PF13912//PF07975//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.49318 BP_3 253.00 6.64 2128 827546729 XP_012545763.1 331 5.7e-28 PREDICTED: uncharacterized protein LOC105841624 isoform X1 [Bombyx mori] -- -- -- -- -- -- -- -- -- Q9YMJ7 144 1.1e-07 Envelope fusion protein OS=Lymantria dispar multicapsid nuclear polyhedrosis virus GN=LdOrf-130 PE=3 SV=1 PF03728//PF06009//PF06008//PF01105//PF04108 Viral DNA-binding protein, zinc binding domain//Laminin Domain II//Laminin Domain I//emp24/gp25L/p24 family/GOLD//Autophagy protein Apg17 GO:0030334//GO:0007165//GO:0006914//GO:0006810//GO:0007155//GO:0030155//GO:0006260//GO:0045995 regulation of cell migration//signal transduction//autophagy//transport//cell adhesion//regulation of cell adhesion//DNA replication//regulation of embryonic development GO:0003677//GO:0008270//GO:0005102 DNA binding//zinc ion binding//receptor binding GO:0016021 integral component of membrane -- -- Cluster-8309.49321 BP_3 577.81 10.72 2889 642933538 XP_008197461.1 3463 0.0e+00 PREDICTED: tyrosine-protein phosphatase non-receptor type 4 [Tribolium castaneum]>gi|270011334|gb|EFA07782.1| hypothetical protein TcasGA2_TC005339 [Tribolium castaneum] 817186761 XM_012432473.1 151 1.49947e-70 PREDICTED: Orussus abietinus tyrosine-protein phosphatase non-receptor type 4 (LOC105703795), transcript variant X5, mRNA K18037 PTPN4, MEG tyrosine-protein phosphatase non-receptor type 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18037 Q9WU22 1835 1.3e-203 Tyrosine-protein phosphatase non-receptor type 4 OS=Mus musculus GN=Ptpn4 PE=1 SV=2 PF00782//PF13180//PF00595//PF00102 Dual specificity phosphatase, catalytic domain//PDZ domain//PDZ domain (Also known as DHR or GLGF)//Protein-tyrosine phosphatase GO:0035335//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding GO:0005856 cytoskeleton KOG0792 Protein tyrosine phosphatase PTPMEG, contains FERM domain Cluster-8309.49323 BP_3 917.00 26.12 1984 -- -- -- -- -- 642926596 XM_008196712.1 35 3.12342e-06 PREDICTED: Tribolium castaneum fasciclin-3 (LOC657272), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49324 BP_3 280.92 3.55 4104 189238110 XP_001814014.1 2184 1.5e-242 PREDICTED: PHD finger protein 12 [Tribolium castaneum]>gi|270008739|gb|EFA05187.1| hypothetical protein TcasGA2_TC015317 [Tribolium castaneum] -- -- -- -- -- K13703 ABHD11 abhydrolase domain-containing protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13703 Q6DRD9 608 3.5e-61 Alpha/beta hydrolase domain-containing protein 11 OS=Danio rerio GN=abhd11 PE=2 SV=1 PF00130//PF00628//PF00498//PF01738//PF03403//PF02450//PF07819//PF12740//PF01764//PF04083//PF07224//PF00975 Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//FHA domain//Dienelactone hydrolase family//Platelet-activating factor acetylhydrolase, isoform II//Lecithin:cholesterol acyltransferase//PGAP1-like protein//Chlorophyllase enzyme//Lipase (class 3)//Partial alpha/beta-hydrolase lipase region//Chlorophyllase//Thioesterase domain GO:0006886//GO:0042967//GO:0006505//GO:0015996//GO:0035556//GO:0046486//GO:0009058//GO:0015994//GO:0006629//GO:0016042 intracellular protein transport//acyl-carrier-protein biosynthetic process//GPI anchor metabolic process//chlorophyll catabolic process//intracellular signal transduction//glycerolipid metabolic process//biosynthetic process//chlorophyll metabolic process//lipid metabolic process//lipid catabolic process GO:0003847//GO:0016787//GO:0008374//GO:0047746//GO:0005515//GO:0016788 1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity//O-acyltransferase activity//chlorophyllase activity//protein binding//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG2382 Predicted alpha/beta hydrolase Cluster-8309.49325 BP_3 131.95 1.62 4215 189238110 XP_001814014.1 2258 4.1e-251 PREDICTED: PHD finger protein 12 [Tribolium castaneum]>gi|270008739|gb|EFA05187.1| hypothetical protein TcasGA2_TC015317 [Tribolium castaneum] -- -- -- -- -- K13703 ABHD11 abhydrolase domain-containing protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13703 Q6DRD9 526 1.1e-51 Alpha/beta hydrolase domain-containing protein 11 OS=Danio rerio GN=abhd11 PE=2 SV=1 PF04083//PF01764//PF07819//PF00975//PF01674//PF07224//PF00130//PF00498//PF00628 Partial alpha/beta-hydrolase lipase region//Lipase (class 3)//PGAP1-like protein//Thioesterase domain//Lipase (class 2)//Chlorophyllase//Phorbol esters/diacylglycerol binding domain (C1 domain)//FHA domain//PHD-finger GO:0009058//GO:0035556//GO:0015996//GO:0006505//GO:0006886//GO:0006629//GO:0015994 biosynthetic process//intracellular signal transduction//chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport//lipid metabolic process//chlorophyll metabolic process GO:0016787//GO:0016788//GO:0047746//GO:0005515 hydrolase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity//protein binding -- -- KOG2382 Predicted alpha/beta hydrolase Cluster-8309.49330 BP_3 174.00 5.31 1870 91081371 XP_971796.1 907 8.2e-95 PREDICTED: coiled-coil domain-containing protein 94 [Tribolium castaneum]>gi|270005184|gb|EFA01632.1| hypothetical protein TcasGA2_TC007202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BW85 635 1.2e-64 Coiled-coil domain-containing protein 94 OS=Homo sapiens GN=CCDC94 PE=1 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- KOG2989 Uncharacterized conserved protein Cluster-8309.49331 BP_3 29.92 2.22 941 642923845 XP_008193902.1 738 1.6e-75 PREDICTED: uncharacterized protein LOC662374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82198 183 1.5e-12 Transforming growth factor-beta-induced protein ig-h3 OS=Mus musculus GN=Tgfbi PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49332 BP_3 327.00 1.17 13813 478254656 ENN74897.1 8505 0.0e+00 hypothetical protein YQE_08475, partial [Dendroctonus ponderosae] 611970121 XM_007480100.1 108 5.79685e-46 PREDICTED: Monodelphis domestica HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1), mRNA K10594 HERC1 E3 ubiquitin-protein ligase HERC1 http://www.genome.jp/dbget-bin/www_bget?ko:K10594 Q15751 3927 0.0e+00 Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens GN=HERC1 PE=1 SV=2 PF01475//PF06817//PF00400//PF00622//PF00632 Ferric uptake regulator family//Reverse transcriptase thumb domain//WD domain, G-beta repeat//SPRY domain//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0006278//GO:0006355 protein ubiquitination//RNA-dependent DNA replication//regulation of transcription, DNA-templated GO:0003964//GO:0004842//GO:0005515//GO:0003700 RNA-directed DNA polymerase activity//ubiquitin-protein transferase activity//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1426 FOG: RCC1 domain Cluster-8309.49336 BP_3 468.22 5.94 4089 270009970 EFA06418.1 1501 2.4e-163 hypothetical protein TcasGA2_TC009297 [Tribolium castaneum] 642927421 XM_962345.3 282 3.20564e-143 PREDICTED: Tribolium castaneum uncharacterized LOC655783 (LOC655783), mRNA -- -- -- -- -- -- -- -- PF06736 Protein of unknown function (DUF1211) GO:0006813 potassium ion transport GO:0005267 potassium channel activity -- -- -- -- Cluster-8309.49337 BP_3 33.47 0.48 3653 189238817 XP_967438.2 689 3.0e-69 PREDICTED: uncharacterized protein LOC655783 [Tribolium castaneum] 642927421 XM_962345.3 208 3.91616e-102 PREDICTED: Tribolium castaneum uncharacterized LOC655783 (LOC655783), mRNA -- -- -- -- -- -- -- -- PF04382//PF06736 SAB domain//Protein of unknown function (DUF1211) GO:0030866//GO:0006813 cortical actin cytoskeleton organization//potassium ion transport GO:0008092//GO:0005267 cytoskeletal protein binding//potassium channel activity GO:0005856 cytoskeleton -- -- Cluster-8309.49338 BP_3 88.87 0.96 4753 91082539 XP_973726.1 1447 5.0e-157 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 800 2.2e-83 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49341 BP_3 11.26 0.65 1124 478254113 ENN74397.1 1017 8.6e-108 hypothetical protein YQE_09015, partial [Dendroctonus ponderosae]>gi|546685434|gb|ERL94938.1| hypothetical protein D910_12210, partial [Dendroctonus ponderosae] -- -- -- -- -- K01136 IDS iduronate 2-sulfatase http://www.genome.jp/dbget-bin/www_bget?ko:K01136 Q08890 548 8.6e-55 Iduronate 2-sulfatase OS=Mus musculus GN=Ids PE=2 SV=3 PF00884//PF01663//PF01676 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Metalloenzyme superfamily GO:0008152 metabolic process GO:0046872//GO:0003824//GO:0008484 metal ion binding//catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.49346 BP_3 91.77 0.86 5418 91084477 XP_971283.1 1848 1.8e-203 PREDICTED: uncharacterized protein LOC659924 [Tribolium castaneum]>gi|270008871|gb|EFA05319.1| hypothetical protein TcasGA2_TC015477 [Tribolium castaneum] -- -- -- -- -- K10581 UBE2O ubiquitin-conjugating enzyme E2 O http://www.genome.jp/dbget-bin/www_bget?ko:K10581 Q9C0C9 640 8.9e-65 E2/E3 hybrid ubiquitin-protein ligase UBE2O OS=Homo sapiens GN=UBE2O PE=1 SV=3 PF05743 UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process -- -- -- -- KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.49348 BP_3 718.49 7.59 4853 91084477 XP_971283.1 2934 0.0e+00 PREDICTED: uncharacterized protein LOC659924 [Tribolium castaneum]>gi|270008871|gb|EFA05319.1| hypothetical protein TcasGA2_TC015477 [Tribolium castaneum] -- -- -- -- -- K10581 UBE2O ubiquitin-conjugating enzyme E2 O http://www.genome.jp/dbget-bin/www_bget?ko:K10581 Q9C0C9 640 8.0e-65 E2/E3 hybrid ubiquitin-protein ligase UBE2O OS=Homo sapiens GN=UBE2O PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.49349 BP_3 901.09 11.67 4013 91079492 XP_968664.1 1430 4.0e-155 PREDICTED: RING finger and transmembrane domain-containing protein 2 [Tribolium castaneum]>gi|270003440|gb|EEZ99887.1| hypothetical protein TcasGA2_TC002671 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UF64 482 1.4e-46 RING finger and transmembrane domain-containing protein 2 OS=Mus musculus GN=Rnft2 PE=2 SV=2 PF15185//PF11789//PF13639//PF12678//PF14634//PF12861//PF00097 Bcl-2-modifying factor, apoptosis//Zinc-finger of the MIZ type in Nse subunit//Ring finger domain//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger) GO:0006915//GO:0016567 apoptotic process//protein ubiquitination GO:0008270//GO:0043169//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//cation binding//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.49350 BP_3 213.00 7.12 1734 189237799 XP_001814012.1 1866 4.8e-206 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 35A [Tribolium castaneum]>gi|270008127|gb|EFA04575.1| PNR-like protein [Tribolium castaneum] -- -- -- -- -- K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MVS5 1292 7.1e-141 Polypeptide N-acetylgalactosaminyltransferase 35A OS=Drosophila melanogaster GN=Pgant35A PE=1 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.49352 BP_3 44.85 0.46 4983 91089905 XP_972496.1 1305 1.5e-140 PREDICTED: UDP-glucuronosyltransferase [Tribolium castaneum]>gi|270013659|gb|EFA10107.1| hypothetical protein TcasGA2_TC012286 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36513 593 2.3e-59 UDP-glucuronosyltransferase 2B14 OS=Oryctolagus cuniculus GN=UGT2B14 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016740//GO:0016758 transferase activity//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.49354 BP_3 211.50 7.31 1687 478258020 ENN78158.1 607 4.5e-60 hypothetical protein YQE_05312, partial [Dendroctonus ponderosae] -- -- -- -- -- K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q7KRY6 484 3.4e-47 Nucleosomal histone kinase 1 OS=Drosophila melanogaster GN=ball PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.49355 BP_3 289.25 1.17 12218 546678376 ERL89009.1 15655 0.0e+00 hypothetical protein D910_06387 [Dendroctonus ponderosae] 861437320 XM_013072408.1 160 6.35494e-75 PREDICTED: Heterocephalus glaber dynein, axonemal, heavy chain 5 (Dnah5), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q96JB1 10616 0.0e+00 Dynein heavy chain 8, axonemal OS=Homo sapiens GN=DNAH8 PE=1 SV=2 PF07728//PF11112//PF09520//PF00004//PF03028 AAA domain (dynein-related subfamily)//Pyocin activator protein PrtN//Type II restriction endonuclease, TdeIII//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor GO:0007017//GO:0006355//GO:0009307//GO:0006308//GO:0007018 microtubule-based process//regulation of transcription, DNA-templated//DNA restriction-modification system//DNA catabolic process//microtubule-based movement GO:0016887//GO:0005524//GO:0009036//GO:0003677//GO:0003777 ATPase activity//ATP binding//Type II site-specific deoxyribonuclease activity//DNA binding//microtubule motor activity GO:0009359//GO:0030286//GO:0005874 Type II site-specific deoxyribonuclease complex//dynein complex//microtubule -- -- Cluster-8309.49357 BP_3 26.47 0.95 1633 546683382 ERL93204.1 503 5.0e-48 hypothetical protein D910_10501, partial [Dendroctonus ponderosae] 642917441 XM_008192979.1 36 7.1203e-07 PREDICTED: Tribolium castaneum jerky protein homolog-like (LOC103312418), mRNA -- -- -- -- -- -- -- -- PF09606 ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.49358 BP_3 96.45 2.78 1962 478257079 ENN77242.1 541 2.4e-52 hypothetical protein YQE_06072, partial [Dendroctonus ponderosae] 642917441 XM_008192979.1 36 8.58624e-07 PREDICTED: Tribolium castaneum jerky protein homolog-like (LOC103312418), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49359 BP_3 437.22 10.65 2270 478257079 ENN77242.1 1174 1.1e-125 hypothetical protein YQE_06072, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.49360 BP_3 848.00 28.42 1730 762092937 XP_011428912.1 230 2.4e-16 PREDICTED: uncharacterized protein LOC105329380 isoform X3 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- P98088 142 1.6e-07 Mucin-5AC OS=Homo sapiens GN=MUC5AC PE=1 SV=4 PF09494 Slx4 endonuclease GO:0006260//GO:0006281//GO:0006308 DNA replication//DNA repair//DNA catabolic process GO:0017108 5'-flap endonuclease activity GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex -- -- Cluster-8309.49361 BP_3 6.35 0.47 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49363 BP_3 270.05 3.27 4271 642921997 XP_008192975.1 1073 1.1e-113 PREDICTED: calcium uniporter protein, mitochondrial [Tribolium castaneum] 884952751 XM_013134023.1 63 1.8468e-21 PREDICTED: Esox lucius mitochondrial calcium uniporter (mcu), transcript variant X2, mRNA -- -- -- -- Q08BI9 672 1.4e-68 Calcium uniporter protein, mitochondrial OS=Danio rerio GN=mcu PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2966 Uncharacterized conserved protein Cluster-8309.49364 BP_3 101.00 2.13 2574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49370 BP_3 472.02 4.34 5535 642939323 XP_969087.2 913 4.9e-95 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.81039e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF03876//PF01588 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Putative tRNA binding domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0000049 DNA-directed RNA polymerase activity//tRNA binding GO:0005730 nucleolus KOG2241 tRNA-binding protein Cluster-8309.49373 BP_3 288.04 6.04 2589 768419593 XP_011550521.1 1889 1.5e-208 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [Plutella xylostella] 695538883 XM_009544325.1 56 8.67368e-18 Heterobasidion irregulare TC 32-1 hypothetical protein mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 A4FV68 1632 4.0e-180 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Bos taurus GN=PPP2R5E PE=1 SV=1 PF01603 Protein phosphatase 2A regulatory B subunit (B56 family) GO:0007165 signal transduction GO:0008601 protein phosphatase type 2A regulator activity GO:0000159 protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.49376 BP_3 44.63 0.47 4823 642935321 XP_008197967.1 172 3.6e-09 PREDICTED: 5-hydroxytryptamine receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49378 BP_3 23.09 1.18 1232 642933391 XP_008197397.1 350 2.1e-30 PREDICTED: cyclin-dependent kinase 2-associated protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49119 216 3.0e-16 Cyclin-dependent kinase 2-associated protein 1 OS=Mesocricetus auratus GN=CDK2AP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4713 Cyclin-dependent kinase 2-associated protein Cluster-8309.49379 BP_3 1364.10 13.90 5023 642936719 XP_008198552.1 2792 0.0e+00 PREDICTED: ATP-dependent RNA helicase DDX54 [Tribolium castaneum]>gi|270000966|gb|EEZ97413.1| hypothetical protein TcasGA2_TC011242 [Tribolium castaneum] 642936718 XM_008200330.1 214 2.49442e-105 PREDICTED: Tribolium castaneum ATP-dependent RNA helicase DDX54 (LOC660698), mRNA K14808 DDX54, DBP10 ATP-dependent RNA helicase DDX54/DBP10 http://www.genome.jp/dbget-bin/www_bget?ko:K14808 Q8K4L0 1764 3.8e-195 ATP-dependent RNA helicase DDX54 OS=Mus musculus GN=Ddx54 PE=1 SV=1 PF08147//PF00974//PF15785//PF00227//PF00270 DBP10CT (NUC160) domain//Rhabdovirus spike glycoprotein//Serine/threonine-protein kinase smg-1//Proteasome subunit//DEAD/DEAH box helicase GO:0051603//GO:0009069//GO:0000184//GO:0016310 proteolysis involved in cellular protein catabolic process//serine family amino acid metabolic process//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//phosphorylation GO:0004298//GO:0016818//GO:0004674//GO:0003676//GO:0008026//GO:0003723//GO:0005524 threonine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//protein serine/threonine kinase activity//nucleic acid binding//ATP-dependent helicase activity//RNA binding//ATP binding GO:0005839//GO:0019031//GO:0005634 proteasome core complex//viral envelope//nucleus KOG0337 ATP-dependent RNA helicase Cluster-8309.49381 BP_3 837.74 6.92 6130 91091096 XP_968472.1 2668 1.7e-298 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58428 391 7.5e-36 ATP-binding cassette sub-family G member 8 OS=Rattus norvegicus GN=Abcg8 PE=2 SV=2 PF01061//PF00005 ABC-2 type transporter//ABC transporter -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.49382 BP_3 2596.97 36.41 3730 91091096 XP_968472.1 1886 4.9e-208 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58428 301 1.2e-25 ATP-binding cassette sub-family G member 8 OS=Rattus norvegicus GN=Abcg8 PE=2 SV=2 PF05297//PF00005//PF01061 Herpesvirus latent membrane protein 1 (LMP1)//ABC transporter//ABC-2 type transporter GO:0006200//GO:0019087 obsolete ATP catabolic process//transformation of host cell by virus GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.49383 BP_3 714.52 18.68 2135 478253336 ENN73697.1 702 5.5e-71 hypothetical protein YQE_09694, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0W2W6 433 3.5e-41 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.49384 BP_3 24.50 0.41 3197 642911928 XP_967929.2 2556 8.6e-286 PREDICTED: uncharacterized protein LOC656296 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60611 151 2.6e-08 DNA-binding protein SATB1 OS=Mus musculus GN=Satb1 PE=1 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG3755 SATB1 matrix attachment region binding protein Cluster-8309.49385 BP_3 32.89 0.68 2615 642934168 XP_008199635.1 1855 1.4e-204 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.89664e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 O95352 1286 5.3e-140 Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1 PF13241//PF00899//PF02826 Putative NAD(P)-binding//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006779//GO:0055114//GO:0019354 porphyrin-containing compound biosynthetic process//oxidation-reduction process//siroheme biosynthetic process GO:0008641//GO:0051287//GO:0043115 small protein activating enzyme activity//NAD binding//precorrin-2 dehydrogenase activity -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.49386 BP_3 101.87 2.76 2069 189236439 XP_001814289.1 886 2.5e-92 PREDICTED: uncharacterized protein LOC100142575 [Tribolium castaneum]>gi|270005928|gb|EFA02376.1| hypothetical protein TcasGA2_TC008051 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08332 Calcium/calmodulin dependent protein kinase II association domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005516//GO:0004683 calmodulin binding//calmodulin-dependent protein kinase activity -- -- -- -- Cluster-8309.49387 BP_3 121.31 0.69 8736 642938612 XP_008199865.1 1750 6.8e-192 PREDICTED: uncharacterized protein LOC655974, partial [Tribolium castaneum] 462373247 APGK01024812.1 79 4.8367e-30 Dendroctonus ponderosae Seq01024822, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF05366//PF00435//PF10541//PF01388 Sarcolipin//Spectrin repeat//Nuclear envelope localisation domain//ARID/BRIGHT DNA binding domain -- -- GO:0003677//GO:0005515//GO:0030234 DNA binding//protein binding//enzyme regulator activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.49388 BP_3 155.93 1.81 4441 642938612 XP_008199865.1 1300 5.2e-140 PREDICTED: uncharacterized protein LOC655974, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49389 BP_3 1365.97 9.55 7185 642938612 XP_008199865.1 2583 1.4e-288 PREDICTED: uncharacterized protein LOC655974, partial [Tribolium castaneum] 462373247 APGK01024812.1 79 3.97434e-30 Dendroctonus ponderosae Seq01024822, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF00435//PF01388//PF10541 Spectrin repeat//ARID/BRIGHT DNA binding domain//Nuclear envelope localisation domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.49391 BP_3 361.99 2.14 8430 642916934 XP_008199560.1 2574 1.8e-287 PREDICTED: serine/threonine-protein kinase HSL1 [Tribolium castaneum] 642916933 XM_008201338.1 374 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase HSL1 (LOC660568), mRNA K08853 AAK AP2-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08853 F1MH24 1145 3.8e-123 AP2-associated protein kinase 1 OS=Bos taurus GN=AAK1 PE=1 SV=2 PF00069//PF07714//PF08925 Protein kinase domain//Protein tyrosine kinase//Domain of Unknown Function (DUF1907) GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005634 nucleus KOG1989 ARK protein kinase family Cluster-8309.49392 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.49396 BP_3 1683.68 39.89 2326 642917609 XP_008191278.1 1425 8.7e-155 PREDICTED: U3 small nucleolar RNA-associated protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VCY6 452 2.4e-43 U3 small nucleolar RNA-associated protein 6 homolog OS=Mus musculus GN=Utp6 PE=2 SV=1 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG2396 HAT (Half-A-TPR) repeat-containing protein Cluster-8309.49399 BP_3 92.50 3.11 1724 91084617 XP_974511.1 940 1.1e-98 PREDICTED: serine/threonine-protein kinase 16 [Tribolium castaneum]>gi|270008645|gb|EFA05093.1| hypothetical protein TcasGA2_TC015191 [Tribolium castaneum] -- -- -- -- -- K08856 STK16 serine/threonine kinase 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08856 P57760 453 1.4e-43 Serine/threonine-protein kinase 16 OS=Rattus norvegicus GN=Stk16 PE=2 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG1989 ARK protein kinase family Cluster-8309.4940 BP_3 6.23 0.32 1230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49400 BP_3 285.04 10.02 1663 91084617 XP_974511.1 1367 3.3e-148 PREDICTED: serine/threonine-protein kinase 16 [Tribolium castaneum]>gi|270008645|gb|EFA05093.1| hypothetical protein TcasGA2_TC015191 [Tribolium castaneum] -- -- -- -- -- K08856 STK16 serine/threonine kinase 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08856 P57760 626 1.1e-63 Serine/threonine-protein kinase 16 OS=Rattus norvegicus GN=Stk16 PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG2345 Serine/threonine protein kinase/TGF-beta stimulated factor Cluster-8309.49402 BP_3 50.48 1.70 1720 91084617 XP_974511.1 1070 9.4e-114 PREDICTED: serine/threonine-protein kinase 16 [Tribolium castaneum]>gi|270008645|gb|EFA05093.1| hypothetical protein TcasGA2_TC015191 [Tribolium castaneum] -- -- -- -- -- K08856 STK16 serine/threonine kinase 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08856 P57760 484 3.5e-47 Serine/threonine-protein kinase 16 OS=Rattus norvegicus GN=Stk16 PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG1989 ARK protein kinase family Cluster-8309.49404 BP_3 374.79 20.27 1183 91082921 XP_972710.1 1216 7.6e-131 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] 462337062 APGK01037684.1 46 1.41219e-12 Dendroctonus ponderosae Seq01037694, whole genome shotgun sequence K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 841 9.6e-89 Annulin OS=Schistocerca americana PE=2 SV=1 PF00868 Transglutaminase family GO:0018149 peptide cross-linking -- -- -- -- -- -- Cluster-8309.49407 BP_3 1073.13 6.98 7704 642928738 XP_008199761.1 3549 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|642928740|ref|XP_008199762.1| PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|270009769|gb|EFA06217.1| hypothetical protein TcasGA2_TC009066 [Tribolium castaneum] 642928739 XM_008201540.1 59 5.59299e-19 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 4 regulatory subunit 3 (LOC663105), transcript variant X2, mRNA K17491 SMEK, PPP4R3 protein phosphatase 4 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17491 Q9VFS5 2688 4.2e-302 Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Drosophila melanogaster GN=flfl PE=1 SV=4 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG2175 Protein predicted to be involved in carbohydrate metabolism Cluster-8309.49408 BP_3 91.52 6.38 983 642917000 XP_008199589.1 252 3.8e-19 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49409 BP_3 163.33 8.87 1179 270009226 EFA05674.1 966 7.4e-102 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXL6 334 5.9e-30 SID1 transmembrane family member 1 OS=Homo sapiens GN=SIDT1 PE=2 SV=2 PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.4941 BP_3 40.67 0.61 3488 270008685 EFA05133.1 1253 1.2e-134 hypothetical protein TcasGA2_TC015248 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00822//PF01699//PF09258 PMP-22/EMP/MP20/Claudin family//Sodium/calcium exchanger protein//Glycosyl transferase family 64 domain GO:0055085//GO:0015012//GO:0006024 transmembrane transport//heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49412 BP_3 105.14 4.12 1522 270009226 EFA05674.1 986 4.6e-104 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXL6 466 3.7e-45 SID1 transmembrane family member 1 OS=Homo sapiens GN=SIDT1 PE=2 SV=2 PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49414 BP_3 67.79 2.28 1726 270009226 EFA05674.1 1253 5.7e-135 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXL6 664 4.7e-68 SID1 transmembrane family member 1 OS=Homo sapiens GN=SIDT1 PE=2 SV=2 PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49415 BP_3 37.75 0.69 2939 642929814 XP_008195987.1 809 3.0e-83 PREDICTED: E3 ubiquitin-protein ligase Topors-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10631 TOPORS E3 ubiquitin-protein ligase Topors http://www.genome.jp/dbget-bin/www_bget?ko:K10631 Q80Z37 253 3.6e-20 E3 ubiquitin-protein ligase Topors OS=Mus musculus GN=Topors PE=1 SV=1 PF00257//PF01480//PF05793 Dehydrin//PWI domain//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0006397//GO:0032968//GO:0006950//GO:0009415//GO:0006367 mRNA processing//positive regulation of transcription elongation from RNA polymerase II promoter//response to stress//response to water//transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.49416 BP_3 76.11 1.23 3270 642918803 XP_008191592.1 1891 1.1e-208 PREDICTED: mitochondrial import receptor subunit TOM70 [Tribolium castaneum]>gi|270005628|gb|EFA02076.1| hypothetical protein TcasGA2_TC007711 [Tribolium castaneum] -- -- -- -- -- K17768 TOM70 mitochondrial import receptor subunit TOM70 http://www.genome.jp/dbget-bin/www_bget?ko:K17768 Q75Q39 1167 4.2e-126 Mitochondrial import receptor subunit TOM70 OS=Rattus norvegicus GN=Tomm70a PE=1 SV=1 PF05822//PF13176//PF13414//PF13371//PF13181//PF13374//PF00515 Pyrimidine 5'-nucleotidase (UMPH-1)//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0008253//GO:0005515//GO:0000287 5'-nucleotidase activity//protein binding//magnesium ion binding GO:0005737 cytoplasm KOG0547 Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72 Cluster-8309.49420 BP_3 1.00 0.31 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01096 Transcription factor S-II (TFIIS) GO:0006351 transcription, DNA-templated GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.49421 BP_3 398.99 15.89 1502 91078286 XP_971953.1 1058 2.0e-112 PREDICTED: negative elongation factor E [Tribolium castaneum]>gi|270003949|gb|EFA00397.1| hypothetical protein TcasGA2_TC003247 [Tribolium castaneum] -- -- -- -- -- K15182 RDBP, NELFE negative elongation factor E http://www.genome.jp/dbget-bin/www_bget?ko:K15182 P92204 626 1.0e-63 Negative elongation factor E OS=Drosophila melanogaster GN=Nelf-E PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0000166//GO:0003676 RNA binding//nucleotide binding//nucleic acid binding -- -- KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-8309.49422 BP_3 129.24 1.77 3802 91093755 XP_969513.1 2086 3.2e-231 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270012977|gb|EFA09425.1| hypothetical protein TcasGA2_TC010636 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 O15254 1438 1.8e-157 Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens GN=ACOX3 PE=1 SV=2 PF01756//PF07716//PF07544//PF05139//PF00441//PF02770//PF00107 Acyl-CoA oxidase//Basic region leucine zipper//RNA polymerase II transcription mediator complex subunit 9//Erythromycin esterase//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Zinc-binding dehydrogenase GO:0006637//GO:0006118//GO:0006355//GO:0006357//GO:0055114//GO:0006635//GO:0046677//GO:0006631 acyl-CoA metabolic process//obsolete electron transport//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//oxidation-reduction process//fatty acid beta-oxidation//response to antibiotic//fatty acid metabolic process GO:0003995//GO:0043565//GO:0003700//GO:0016627//GO:0001104//GO:0003997 acyl-CoA dehydrogenase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//RNA polymerase II transcription cofactor activity//acyl-CoA oxidase activity GO:0016592//GO:0005777//GO:0005667 mediator complex//peroxisome//transcription factor complex KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.49424 BP_3 187.08 5.70 1874 345480784 XP_001605371.2 299 2.6e-24 PREDICTED: GTP cyclohydrolase 1 isoform X2 [Nasonia vitripennis] 768436468 XM_011561420.1 91 2.18359e-37 PREDICTED: Plutella xylostella GTP cyclohydrolase 1 (LOC105390169), transcript variant X2, mRNA K01495 GCH1, folE GTP cyclohydrolase I http://www.genome.jp/dbget-bin/www_bget?ko:K01495 P48596 283 7.7e-24 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2698 GTP cyclohydrolase I Cluster-8309.49425 BP_3 26.60 0.43 3250 642938181 XP_008191045.1 480 4.6e-45 PREDICTED: GTP cyclohydrolase 1 isoform X2 [Tribolium castaneum] 768442784 XM_011564875.1 153 1.30584e-71 PREDICTED: Plutella xylostella GTP cyclohydrolase 1-like (LOC105393140), mRNA K01495 GCH1, folE GTP cyclohydrolase I http://www.genome.jp/dbget-bin/www_bget?ko:K01495 P48596 455 1.5e-43 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 PF01091//PF06495//PF14489//PF00344//PF12678 PTN/MK heparin-binding protein family, C-terminal domain//Fruit fly transformer protein//QueF-like protein//SecY translocase//RING-H2 zinc finger GO:0006397//GO:0007165//GO:0008616//GO:0040007//GO:0008283//GO:0015031//GO:0046660 mRNA processing//signal transduction//queuosine biosynthetic process//growth//cell proliferation//protein transport//female sex differentiation GO:0008083//GO:0033739//GO:0008270 growth factor activity//preQ1 synthase activity//zinc ion binding GO:0005634//GO:0016020 nucleus//membrane KOG2698 GTP cyclohydrolase I Cluster-8309.49426 BP_3 95440.00 4430.61 1330 91093827 XP_966784.1 445 2.2e-41 PREDICTED: proline-rich protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49429 BP_3 134.75 4.46 1749 478254618 ENN74861.1 748 2.1e-76 hypothetical protein YQE_08631, partial [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 343 7.9e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF06687//PF00230//PF07043 SUR7/PalI family//Major intrinsic protein//Protein of unknown function (DUF1328) GO:0006810 transport GO:0005215 transporter activity GO:0005886//GO:0016020 plasma membrane//membrane -- -- Cluster-8309.49430 BP_3 79.18 6.58 872 642923081 XP_970728.2 443 2.4e-41 PREDICTED: aquaporin NIP1-2-like [Tribolium castaneum] -- -- -- -- -- K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q25074 367 6.5e-34 Aquaporin OS=Haematobia irritans exigua PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.49431 BP_3 476.08 56.34 699 478255840 ENN76048.1 300 7.4e-25 hypothetical protein YQE_07421, partial [Dendroctonus ponderosae]>gi|546680467|gb|ERL90733.1| hypothetical protein D910_08080 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16692 Folliculin C-terminal domain GO:0043087 regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.49433 BP_3 458.22 7.21 3356 91090986 XP_974863.1 2803 0.0e+00 PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936123|ref|XP_008198309.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936125|ref|XP_008198310.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|270013188|gb|EFA09636.1| hypothetical protein TcasGA2_TC011759 [Tribolium castaneum] 642936121 XM_969770.3 59 2.42267e-19 PREDICTED: Tribolium castaneum ubiquitin thioesterase trabid (LOC663735), transcript variant X1, mRNA K11862 ZRANB1, TRABID ubiquitin thioesterase ZRANB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11862 Q9VH90 1920 2.1e-213 Ubiquitin thioesterase trabid OS=Drosophila melanogaster GN=trbd PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG4345 NF-kappa B regulator AP20/Cezanne Cluster-8309.49435 BP_3 2332.00 29.73 4073 189235802 XP_976325.2 307 6.7e-25 PREDICTED: DNA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49437 BP_3 21.79 1.01 1328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49438 BP_3 140.00 1.78 4089 546685504 ERL95002.1 782 5.6e-80 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 182 8.6e-12 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.49439 BP_3 16.91 0.63 1588 189236353 XP_001807129.1 1704 2.7e-187 PREDICTED: signal recognition particle receptor subunit alpha homolog [Tribolium castaneum]>gi|270005877|gb|EFA02325.1| hypothetical protein TcasGA2_TC007993 [Tribolium castaneum] 720030593 XM_010267260.1 42 3.19677e-10 PREDICTED: Nelumbo nucifera signal recognition particle receptor subunit alpha-like (LOC104603264), transcript variant X4, mRNA K13431 SRPR signal recognition particle receptor subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13431 Q9U5L1 1424 3.2e-156 Signal recognition particle receptor subunit alpha homolog OS=Drosophila melanogaster GN=Gtp-bp PE=1 SV=2 PF01926//PF03266//PF04086//PF02881//PF00448 50S ribosome-binding GTPase//NTPase//Signal recognition particle, alpha subunit, N-terminal//SRP54-type protein, helical bundle domain//SRP54-type protein, GTPase domain GO:0006886//GO:0006614//GO:0006184 intracellular protein transport//SRP-dependent cotranslational protein targeting to membrane//obsolete GTP catabolic process GO:0003924//GO:0098519//GO:0005047//GO:0005525 GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//signal recognition particle binding//GTP binding GO:0005786//GO:0005785 signal recognition particle, endoplasmic reticulum targeting//signal recognition particle receptor complex KOG0781 Signal recognition particle receptor, alpha subunit Cluster-8309.4944 BP_3 37.31 2.25 1092 642922841 XP_001813804.2 546 3.4e-53 PREDICTED: uncharacterized protein LOC100141768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05297//PF03694 Herpesvirus latent membrane protein 1 (LMP1)//Erg28 like protein GO:0019087 transformation of host cell by virus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49443 BP_3 56.28 6.19 730 478252829 ENN73218.1 578 4.5e-57 hypothetical protein YQE_10115, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49444 BP_3 1410.57 19.85 3716 589094703 AHK59785.1 1404 3.8e-152 major facilitator superfamily protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU13 144 2.0e-07 Protein spinster homolog 1 OS=Danio rerio GN=spns1 PE=2 SV=1 PF01220//PF00083//PF07690 Dehydroquinase class II//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006571//GO:0000162//GO:0009094//GO:0055085 tyrosine biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process//transmembrane transport GO:0003855//GO:0022857 3-dehydroquinate dehydratase activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49448 BP_3 200.83 2.02 5089 642917330 XP_008199256.1 2195 9.9e-244 PREDICTED: kazrin isoform X4 [Tribolium castaneum] 642917329 XM_008201034.1 314 6.50108e-161 PREDICTED: Tribolium castaneum kazrin (LOC658072), transcript variant X4, mRNA -- -- -- -- Q674X7 600 3.6e-60 Kazrin OS=Homo sapiens GN=KAZN PE=1 SV=2 PF00536//PF07647//PF02183//PF12285//PF09482 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Homeobox associated leucine zipper//Protein of unknown function (DUF3621)//Bacterial type III secretion apparatus protein (OrgA_MxiK) GO:0006355//GO:0009405 regulation of transcription, DNA-templated//pathogenesis GO:0003700//GO:0004252//GO:0043565//GO:0070008//GO:0005515 transcription factor activity, sequence-specific DNA binding//serine-type endopeptidase activity//sequence-specific DNA binding//serine-type exopeptidase activity//protein binding GO:0005667 transcription factor complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.49450 BP_3 79.65 0.49 8188 649572303 NP_001280516.1 1401 1.9e-151 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 642931552 XM_961600.3 337 1.71744e-173 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1298 6.7e-141 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF02297//PF00514//PF02778//PF02739//PF01602//PF01974//PF02985//PF11698 Cytochrome oxidase c subunit VIb//Armadillo/beta-catenin-like repeat//tRNA intron endonuclease, N-terminal domain//5'-3' exonuclease, N-terminal resolvase-like domain//Adaptin N terminal region//tRNA intron endonuclease, catalytic C-terminal domain//HEAT repeat//V-ATPase subunit H GO:0015992//GO:0051252//GO:0006123//GO:0006886//GO:0016192//GO:0006388//GO:0006119//GO:0015991 proton transport//regulation of RNA metabolic process//mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//vesicle-mediated transport//tRNA splicing, via endonucleolytic cleavage and ligation//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961//GO:0004129//GO:0003677//GO:0000213//GO:0016820//GO:0005515 proton-transporting ATPase activity, rotational mechanism//cytochrome-c oxidase activity//DNA binding//tRNA-intron endonuclease activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0005739//GO:0000214//GO:0030117//GO:0000221//GO:0045277 mitochondrion//tRNA-intron endonuclease complex//membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain//respiratory chain complex IV KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.49451 BP_3 232.84 2.06 5730 270007165 EFA03613.1 1428 9.7e-155 hypothetical protein TcasGA2_TC013701 [Tribolium castaneum] 642922583 XM_008195015.1 341 7.17194e-176 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X3, mRNA -- -- -- -- P55197 839 7.9e-88 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG0956 PHD finger protein AF10 Cluster-8309.49452 BP_3 181.00 4.35 2298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49455 BP_3 3030.46 25.67 5982 642916405 XP_008191009.1 3474 0.0e+00 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.5e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF00018//PF14604//PF08397 SH3 domain//Variant SH3 domain//IRSp53/MIM homology domain GO:0007009 plasma membrane organization GO:0005515 protein binding -- -- -- -- Cluster-8309.49456 BP_3 82.87 2.36 1987 270003897 EFA00345.1 1623 8.2e-178 hypothetical protein TcasGA2_TC003184 [Tribolium castaneum] 766920220 XM_011506269.1 107 2.9561e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1205 9.9e-131 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF00437//PF00270//PF03060//PF03368 Type II/IV secretion system protein//DEAD/DEAH box helicase//Nitronate monooxygenase//Dicer dimerisation domain GO:0006810//GO:0006807//GO:0055114//GO:0051252 transport//nitrogen compound metabolic process//oxidation-reduction process//regulation of RNA metabolic process GO:0005524//GO:0018580//GO:0003676//GO:0016891 ATP binding//nitronate monooxygenase activity//nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.49458 BP_3 4.00 0.36 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49462 BP_3 53.00 6.77 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49463 BP_3 32.50 0.47 3607 478252538 ENN72954.1 1831 1.1e-201 hypothetical protein YQE_10425, partial [Dendroctonus ponderosae] -- -- -- -- -- K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 O08648 296 4.6e-25 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.49464 BP_3 737.71 3.98 9219 91076832 XP_974636.1 3950 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 224 1.26754e-110 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 Q9Y6R4 854 2.3e-89 Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens GN=MAP3K4 PE=1 SV=2 PF02744//PF07714//PF00069 Galactose-1-phosphate uridyl transferase, C-terminal domain//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0009117//GO:0006012 protein phosphorylation//nucleotide metabolic process//galactose metabolic process GO:0008108//GO:0004672//GO:0005524//GO:0000166 UDP-glucose:hexose-1-phosphate uridylyltransferase activity//protein kinase activity//ATP binding//nucleotide binding -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.49465 BP_3 1073.93 33.83 1822 478252220 ENN72648.1 669 3.1e-67 hypothetical protein YQE_10746, partial [Dendroctonus ponderosae] 645003522 XM_008214370.1 95 1.26802e-39 PREDICTED: Nasonia vitripennis high affinity copper uptake protein 1 (LOC100122867), transcript variant X3, mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 340 1.8e-30 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145 Ctr copper transporter family GO:0006825//GO:0035434 copper ion transport//copper ion transmembrane transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane KOG3386 Copper transporter Cluster-8309.49466 BP_3 18.00 2.31 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00957//PF05434 Synaptobrevin//TMEM9 GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49467 BP_3 14.79 1.63 729 270007921 EFA04369.1 175 2.4e-10 hypothetical protein TcasGA2_TC014667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49469 BP_3 556.94 15.98 1972 189234241 XP_976116.2 673 1.2e-67 PREDICTED: high affinity copper uptake protein 1 isoform X2 [Tribolium castaneum] 645003520 XM_008214369.1 86 1.38422e-34 PREDICTED: Nasonia vitripennis high affinity copper uptake protein 1 (LOC100122867), transcript variant X2, mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 362 5.6e-33 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145 Ctr copper transporter family GO:0006825//GO:0035434 copper ion transport//copper ion transmembrane transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane KOG3386 Copper transporter Cluster-8309.49470 BP_3 35.00 0.64 2921 642927770 XP_008195398.1 727 9.5e-74 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 145 1.2e-07 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF02018 Carbohydrate binding domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds -- -- -- -- Cluster-8309.49473 BP_3 230.24 20.89 823 91081479 XP_974351.1 873 3.1e-91 PREDICTED: dynactin subunit 5 [Tribolium castaneum]>gi|270006145|gb|EFA02593.1| hypothetical protein TcasGA2_TC008312 [Tribolium castaneum] 642920959 XM_969258.2 155 2.4797e-73 PREDICTED: Tribolium castaneum dynactin subunit 5 (LOC663200), mRNA K10427 DCTN5 dynactin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10427 Q5R559 670 4.5e-69 Dynactin subunit 5 OS=Pongo abelii GN=DCTN5 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772//GO:0016740 transferase activity, transferring phosphorus-containing groups//transferase activity -- -- KOG3121 Dynactin, subunit p25 Cluster-8309.49474 BP_3 13.09 1.87 630 91081479 XP_974351.1 676 1.7e-68 PREDICTED: dynactin subunit 5 [Tribolium castaneum]>gi|270006145|gb|EFA02593.1| hypothetical protein TcasGA2_TC008312 [Tribolium castaneum] 642920959 XM_969258.2 128 1.91331e-58 PREDICTED: Tribolium castaneum dynactin subunit 5 (LOC663200), mRNA K10427 DCTN5 dynactin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10427 Q5R559 513 5.5e-51 Dynactin subunit 5 OS=Pongo abelii GN=DCTN5 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772//GO:0016740 transferase activity, transferring phosphorus-containing groups//transferase activity -- -- KOG3121 Dynactin, subunit p25 Cluster-8309.49475 BP_3 401.51 6.01 3514 91090862 XP_972769.1 1643 6.9e-180 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 132 6.6682e-60 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 O35864 1371 9.9e-150 COP9 signalosome complex subunit 5 OS=Mus musculus GN=Cops5 PE=1 SV=3 PF04479//PF03083//PF01040//PF01398 RTA1 like protein//Sugar efflux transporter for intercellular exchange//UbiA prenyltransferase family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0006950 response to stress GO:0004659//GO:0005515 prenyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.49476 BP_3 10.17 0.61 1089 91093645 XP_967622.1 295 4.4e-24 PREDICTED: translation initiation factor eIF-2B subunit beta [Tribolium castaneum]>gi|270015813|gb|EFA12261.1| hypothetical protein TcasGA2_TC016125 [Tribolium castaneum] -- -- -- -- -- K03754 EIF2B2 translation initiation factor eIF-2B subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03754 Q90511 226 1.8e-17 Translation initiation factor eIF-2B subunit beta OS=Takifugu rubripes GN=eif2b2 PE=3 SV=1 PF04209//PF01008 homogentisate 1,2-dioxygenase//Initiation factor 2 subunit family GO:0055114//GO:0042207//GO:0044237//GO:0006570//GO:0006559 oxidation-reduction process//styrene catabolic process//cellular metabolic process//tyrosine metabolic process//L-phenylalanine catabolic process GO:0004411 homogentisate 1,2-dioxygenase activity -- -- KOG1465 Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7) Cluster-8309.49477 BP_3 466.25 3.95 5987 642911239 XP_008199721.1 3998 0.0e+00 PREDICTED: IQ motif and SEC7 domain-containing protein 1 isoform X1 [Tribolium castaneum] 641661643 XM_001945108.3 182 1.82988e-87 PREDICTED: Acyrthosiphon pisum IQ motif and SEC7 domain-containing protein 1 (LOC100162626), transcript variant X2, mRNA K12495 IQSEC IQ motif and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12495 Q6DN90 1206 2.3e-130 IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens GN=IQSEC1 PE=1 SV=1 PF01369//PF00612 Sec7 domain//IQ calmodulin-binding motif GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005086 protein binding//ARF guanyl-nucleotide exchange factor activity -- -- KOG0931 Predicted guanine nucleotide exchange factor, contains Sec7 domain Cluster-8309.49480 BP_3 118.00 0.86 6895 641650328 XP_008189178.1 986 2.1e-103 PREDICTED: uncharacterized protein LOC103311361 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02160//PF09668 Cauliflower mosaic virus peptidase (A3)//Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.49481 BP_3 17.77 0.67 1561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49484 BP_3 360.32 30.45 862 332373702 AEE61992.1 351 1.1e-30 unknown [Dendroctonus ponderosae]>gi|478250661|gb|ENN71153.1| hypothetical protein YQE_12084, partial [Dendroctonus ponderosae]>gi|546677245|gb|ERL88114.1| hypothetical protein D910_05503 [Dendroctonus ponderosae] -- -- -- -- -- K05357 VKORC1 vitamin-K-epoxide reductase (warfarin-sensitive) http://www.genome.jp/dbget-bin/www_bget?ko:K05357 Q8N0U8 229 6.4e-18 Vitamin K epoxide reductase complex subunit 1-like protein 1 OS=Homo sapiens GN=VKORC1L1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49489 BP_3 5.65 0.76 652 91087589 XP_971974.1 430 5.8e-40 PREDICTED: RNA polymerase II subunit A C-terminal domain phosphatase [Tribolium castaneum]>gi|270010700|gb|EFA07148.1| hypothetical protein TcasGA2_TC010139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.49490 BP_3 56.48 2.73 1289 91090252 XP_969934.1 408 4.1e-37 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 Q9CPQ3 236 1.5e-18 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=2 SV=3 PF04281 Mitochondrial import receptor subunit Tom22 GO:0006886 intracellular protein transport -- -- GO:0005741 mitochondrial outer membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.49491 BP_3 49.00 1.86 1563 478256534 ENN76718.1 642 3.6e-64 hypothetical protein YQE_06783, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q0VAW7 348 1.9e-31 Zinc finger protein 112 OS=Mus musculus GN=Znf112 PE=2 SV=2 PF00096//PF13465//PF00130//PF02892//PF13912//PF05191//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//BED zinc finger//C2H2-type zinc finger//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0046034//GO:0006144//GO:0035556 ATP metabolic process//purine nucleobase metabolic process//intracellular signal transduction GO:0046872//GO:0004017//GO:0003677 metal ion binding//adenylate kinase activity//DNA binding -- -- -- -- Cluster-8309.49492 BP_3 31.45 0.59 2875 91084671 XP_966504.1 791 3.5e-81 PREDICTED: lambda-crystallin [Tribolium castaneum]>gi|270008625|gb|EFA05073.1| hypothetical protein TcasGA2_TC015170 [Tribolium castaneum] -- -- -- -- -- K13247 CRYL1 L-gulonate 3-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K13247 P14755 502 4.7e-49 Lambda-crystallin OS=Oryctolagus cuniculus GN=CRYL1 PE=1 SV=3 PF02737//PF03446//PF00725//PF12592 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//Protein of unknown function (DUF3763) GO:0006633//GO:0018874//GO:0006098//GO:0006552//GO:0006631//GO:0006574//GO:0006550//GO:0006554//GO:0055114//GO:0019521//GO:0006568 fatty acid biosynthetic process//benzoate metabolic process//pentose-phosphate shunt//leucine catabolic process//fatty acid metabolic process//valine catabolic process//isoleucine catabolic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process GO:0016491//GO:0016820//GO:0070403//GO:0003857//GO:0004616 oxidoreductase activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//NAD+ binding//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG2305 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.49493 BP_3 192.88 4.60 2314 642915206 XP_008190520.1 275 1.9e-21 PREDICTED: gelsolin-related protein of 125 kDa isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49496 BP_3 6.92 0.39 1142 642915518 XP_968660.2 698 8.6e-71 PREDICTED: syntaxin-8 [Tribolium castaneum] -- -- -- -- -- K08501 STX8 syntaxin 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08501 Q3T075 245 1.2e-19 Syntaxin-8 OS=Bos taurus GN=STX8 PE=2 SV=1 PF11744//PF05739//PF06009 Aluminium activated malate transporter//SNARE domain//Laminin Domain II GO:0015743//GO:0007155 malate transport//cell adhesion GO:0005515 protein binding -- -- KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.49498 BP_3 22.76 0.62 2059 546674389 ERL85776.1 973 2.0e-102 hypothetical protein D910_03191 [Dendroctonus ponderosae] 241813187 XM_002414589.1 161 2.93775e-76 Ixodes scapularis serine/threonine protein kinase TAO1, putative, mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 Q7L7X3 619 9.2e-63 Serine/threonine-protein kinase TAO1 OS=Homo sapiens GN=TAOK1 PE=1 SV=1 PF05392//PF02805//PF04689//PF02364 Cytochrome C oxidase chain VIIB//Metal binding domain of Ada//DNA binding protein S1FA//1,3-beta-glucan synthase component GO:0005985//GO:0005982//GO:0006075//GO:0006281//GO:0006123//GO:0015992//GO:0006355 sucrose metabolic process//starch metabolic process//(1->3)-beta-D-glucan biosynthetic process//DNA repair//mitochondrial electron transport, cytochrome c to oxygen//proton transport//regulation of transcription, DNA-templated GO:0003677//GO:0004129//GO:0003843//GO:0008270//GO:0008168 DNA binding//cytochrome-c oxidase activity//1,3-beta-D-glucan synthase activity//zinc ion binding//methyltransferase activity GO:0005746//GO:0045277//GO:0005634//GO:0016020//GO:0000148 mitochondrial respiratory chain//respiratory chain complex IV//nucleus//membrane//1,3-beta-D-glucan synthase complex KOG0577 Serine/threonine protein kinase Cluster-8309.4950 BP_3 1.00 0.43 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49500 BP_3 111.48 1.33 4332 270014937 EFA11385.1 608 8.9e-60 hypothetical protein TcasGA2_TC011545 [Tribolium castaneum] -- -- -- -- -- K10694 ZNRF1_2 E3 ubiquitin-protein ligase ZNRF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10694 Q8NHG8 395 1.8e-36 E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens GN=ZNRF2 PE=1 SV=1 PF01612//PF15926//PF13639//PF14634//PF12906//PF17123//PF12678//PF00097 3'-5' exonuclease//E3 ubiquitin-protein ligase RNF220//Ring finger domain//zinc-RING finger domain//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0090263//GO:0016567//GO:0006139 positive regulation of canonical Wnt signaling pathway//protein ubiquitination//nucleobase-containing compound metabolic process GO:0005515//GO:0003676//GO:0008408//GO:0008270//GO:0046872 protein binding//nucleic acid binding//3'-5' exonuclease activity//zinc ion binding//metal ion binding -- -- KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.49503 BP_3 79.26 0.93 4409 91093228 XP_967462.1 705 5.1e-71 PREDICTED: phosphopantothenoylcysteine decarboxylase [Tribolium castaneum]>gi|270016594|gb|EFA13040.1| hypothetical protein TcasGA2_TC010571 [Tribolium castaneum] -- -- -- -- -- K01598 PPCDC, coaC phosphopantothenoylcysteine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01598 Q8BZB2 574 3.3e-57 Phosphopantothenoylcysteine decarboxylase OS=Mus musculus GN=Ppcdc PE=2 SV=1 PF02441//PF05676//PF02297//PF08070//PF02569 Flavoprotein//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Cytochrome oxidase c subunit VIb//DTHCT (NUC029) region//Pantoate-beta-alanine ligase GO:0015940//GO:0006120//GO:0006123//GO:0006814//GO:0006118//GO:0006265//GO:0019482//GO:0015992//GO:0008152//GO:0006744 pantothenate biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//mitochondrial electron transport, cytochrome c to oxygen//sodium ion transport//obsolete electron transport//DNA topological change//beta-alanine metabolic process//proton transport//metabolic process//ubiquinone biosynthetic process GO:0005524//GO:0008137//GO:0003677//GO:0003824//GO:0003954//GO:0004592//GO:0003918//GO:0004129 ATP binding//NADH dehydrogenase (ubiquinone) activity//DNA binding//catalytic activity//NADH dehydrogenase activity//pantoate-beta-alanine ligase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity//cytochrome-c oxidase activity GO:0005739//GO:0005634//GO:0045277 mitochondrion//nucleus//respiratory chain complex IV KOG0672 Halotolerance protein HAL3 (contains flavoprotein domain) Cluster-8309.49508 BP_3 605.14 12.73 2583 546684930 ERL94512.1 2755 5.8e-309 hypothetical protein D910_11789 [Dendroctonus ponderosae] 641669724 XM_001950701.3 53 4.02599e-16 PREDICTED: Acyrthosiphon pisum myotubularin-related protein 6 (LOC100169408), transcript variant X2, mRNA K18083 MTMR6_7_8 myotubularin-related protein 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K18083 Q5F452 1701 4.0e-188 Myotubularin-related protein 8 OS=Gallus gallus GN=MTMR8 PE=2 SV=1 PF01363//PF00782//PF00102//PF13639 FYVE zinc finger//Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Ring finger domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008270//GO:0008138//GO:0005515//GO:0004725//GO:0046872 zinc ion binding//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//metal ion binding -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.49509 BP_3 8.41 0.48 1129 507954529 XP_004684958.1 923 6.9e-97 PREDICTED: T-complex protein 1 subunit zeta-2 isoform X1 [Condylura cristata] 312068591 XM_003137238.1 74 3.66765e-28 Loa loa T-complex protein 1 (LOAG_01700) mRNA, complete cds K09498 CCT6 T-complex protein 1 subunit zeta http://www.genome.jp/dbget-bin/www_bget?ko:K09498 Q8L7N0 792 4.4e-83 T-complex protein 1 subunit zeta 2 OS=Arabidopsis thaliana GN=CCT6B PE=1 SV=1 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0359 Chaperonin complex component, TCP-1 zeta subunit (CCT6) Cluster-8309.49510 BP_3 37.71 4.50 696 478252124 ENN72555.1 292 6.2e-24 hypothetical protein YQE_10895, partial [Dendroctonus ponderosae] -- -- -- -- -- K18747 SXL protein sex-lethal http://www.genome.jp/dbget-bin/www_bget?ko:K18747 Q15717 170 3.6e-11 ELAV-like protein 1 OS=Homo sapiens GN=ELAVL1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.49511 BP_3 9.45 0.34 1636 642915222 XP_008190529.1 1936 3.4e-214 PREDICTED: TGF-beta receptor type-1 isoform X1 [Tribolium castaneum] 589944031 XM_006984651.1 98 2.44176e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 O46680 1455 8.4e-160 TGF-beta receptor type-1 OS=Bos taurus GN=TGFBR1 PE=2 SV=1 PF08515//PF00069//PF01064//PF07714 Transforming growth factor beta type I GS-motif//Protein kinase domain//Activin types I and II receptor domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468//GO:0007178 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004672//GO:0004675//GO:0005524 protein kinase activity//transmembrane receptor protein serine/threonine kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.49512 BP_3 841.34 25.71 1869 91082933 XP_972996.1 1070 1.0e-113 PREDICTED: uncharacterized protein LOC661762 [Tribolium castaneum]>gi|270007056|gb|EFA03504.1| hypothetical protein TcasGA2_TC013505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49514 BP_3 477.93 4.61 5294 546680010 ERL90372.1 1094 4.8e-116 hypothetical protein D910_07721 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6VMQ6 269 9.1e-22 Activating transcription factor 7-interacting protein 1 OS=Homo sapiens GN=ATF7IP PE=1 SV=3 PF06156//PF16794//PF17060 Protein of unknown function (DUF972)//Fibronectin-III type domain//Monopolar spindle protein 2 GO:0030474//GO:0071988//GO:0006260 spindle pole body duplication//protein localization to spindle pole body//DNA replication GO:0005515 protein binding -- -- -- -- Cluster-8309.49517 BP_3 15.00 1.22 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49519 BP_3 5.20 0.33 1054 322786223 EFZ12827.1 793 7.6e-82 hypothetical protein SINV_02089, partial [Solenopsis invicta] 505849574 XM_004618186.1 109 1.19449e-47 PREDICTED: Sorex araneus adaptor-related protein complex 3, sigma 1 subunit (AP3S1), mRNA K12399 AP3S AP-3 complex subunit sigma http://www.genome.jp/dbget-bin/www_bget?ko:K12399 Q8BSZ2 695 7.2e-72 AP-3 complex subunit sigma-2 OS=Mus musculus GN=Ap3s2 PE=1 SV=1 PF00159 Pancreatic hormone peptide GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region KOG0936 Clathrin adaptor complex, small subunit Cluster-8309.49522 BP_3 35.28 0.66 2868 642923312 XP_972626.2 1933 1.3e-213 PREDICTED: T-box transcription factor TBX20-like isoform X2 [Tribolium castaneum] 641673418 XM_008188106.1 219 2.35363e-108 PREDICTED: Acyrthosiphon pisum T-box transcription factor TBX20-like (LOC100167986), partial mRNA K10185 TBX20 T-box protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10185 Q9ES03 974 8.8e-104 T-box transcription factor TBX20 OS=Mus musculus GN=Tbx20 PE=2 SV=3 PF00907 T-box GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3586 TBX1 and related T-box transcription factors Cluster-8309.49523 BP_3 1182.62 11.44 5274 642930931 XP_008196146.1 2320 3.3e-258 PREDICTED: ephrin type-A receptor 4-B isoform X2 [Tribolium castaneum] 642930930 XM_008197924.1 475 0 PREDICTED: Tribolium castaneum ephrin type-A receptor 4-B (LOC658635), transcript variant X2, mRNA K05110 EPHB1, ELK, NET Eph receptor B1 http://www.genome.jp/dbget-bin/www_bget?ko:K05110 P54755 1396 1.9e-152 Ephrin type-A receptor 5 OS=Gallus gallus GN=EPHA5 PE=2 SV=1 PF16656//PF00041//PF07731//PF06293//PF00536//PF05434//PF04587//PF07647//PF00069//PF07714 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Multicopper oxidase//Lipopolysaccharide kinase (Kdo/WaaP) family//SAM domain (Sterile alpha motif)//TMEM9//ADP-specific Phosphofructokinase/Glucokinase conserved region//SAM domain (Sterile alpha motif)//Protein kinase domain//Protein tyrosine kinase GO:0019497//GO:0006468//GO:0006771//GO:0005975//GO:0055114 hexachlorocyclohexane metabolic process//protein phosphorylation//riboflavin metabolic process//carbohydrate metabolic process//oxidation-reduction process GO:0005507//GO:0005524//GO:0005515//GO:0016491//GO:0003993//GO:0016773//GO:0046872//GO:0004672 copper ion binding//ATP binding//protein binding//oxidoreductase activity//acid phosphatase activity//phosphotransferase activity, alcohol group as acceptor//metal ion binding//protein kinase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.49525 BP_3 10.32 0.71 996 642915929 XP_008190815.1 181 6.6e-11 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF09478//PF00620//PF01025//PF01920 Outer membrane protein (OmpH-like)//Carbohydrate binding domain CBM49//RhoGAP domain//GrpE//Prefoldin subunit GO:0007165//GO:0006457 signal transduction//protein folding GO:0051087//GO:0042803//GO:0051082//GO:0000774//GO:0030246 chaperone binding//protein homodimerization activity//unfolded protein binding//adenyl-nucleotide exchange factor activity//carbohydrate binding GO:0016272 prefoldin complex -- -- Cluster-8309.49526 BP_3 410.49 4.20 5002 642915929 XP_008190815.1 812 2.3e-83 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 400 5.5e-37 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.49527 BP_3 21.10 1.00 1309 642914502 XP_008201702.1 1612 1.0e-176 PREDICTED: RUN and FYVE domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7L099 792 5.1e-83 Protein RUFY3 OS=Homo sapiens GN=RUFY3 PE=1 SV=1 PF06005 Protein of unknown function (DUF904) GO:0000917//GO:0043093 barrier septum assembly//FtsZ-dependent cytokinesis -- -- GO:0005737 cytoplasm -- -- Cluster-8309.4953 BP_3 132.31 2.36 2991 642919458 XP_008191877.1 3114 0.0e+00 PREDICTED: gamma-tubulin complex component 2-like [Tribolium castaneum] -- -- -- -- -- K16569 TUBGCP2, GCP2 gamma-tubulin complex component 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16569 Q9BSJ2 1510 6.4e-166 Gamma-tubulin complex component 2 OS=Homo sapiens GN=TUBGCP2 PE=1 SV=2 PF04130 Spc97 / Spc98 family GO:0000226//GO:0090063 microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0005815//GO:0000922 microtubule organizing center//spindle pole KOG2001 Gamma-tubulin complex, DGRIP84/SPC97 component Cluster-8309.49533 BP_3 692.40 10.81 3380 270008598 EFA05046.1 2573 9.7e-288 hypothetical protein TcasGA2_TC015138 [Tribolium castaneum] 817328593 XM_012435835.1 362 0 PREDICTED: Aotus nancymaae adaptor-related protein complex 3, delta 1 subunit (AP3D1), mRNA K12396 AP3D1 AP-3 complex subunit delta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12396 O54774 1906 8.8e-212 AP-3 complex subunit delta-1 OS=Mus musculus GN=Ap3d1 PE=1 SV=1 PF11698//PF01602//PF02985//PF14532 V-ATPase subunit H//Adaptin N terminal region//HEAT repeat//Sigma-54 interaction domain GO:0006355//GO:0015991//GO:0006886//GO:0016192 regulation of transcription, DNA-templated//ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle-mediated transport GO:0005524//GO:0016820//GO:0008134//GO:0005515 ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//transcription factor binding//protein binding GO:0030117//GO:0005667//GO:0000221 membrane coat//transcription factor complex//vacuolar proton-transporting V-type ATPase, V1 domain KOG1059 Vesicle coat complex AP-3, delta subunit Cluster-8309.49534 BP_3 537.88 7.53 3733 91091446 XP_972658.1 1633 1.1e-178 PREDICTED: kanadaptin [Tribolium castaneum]>gi|270000979|gb|EEZ97426.1| hypothetical protein TcasGA2_TC011256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BWU0 920 2.1e-97 Kanadaptin OS=Homo sapiens GN=SLC4A1AP PE=1 SV=1 PF03368//PF00498 Dicer dimerisation domain//FHA domain GO:0051252 regulation of RNA metabolic process GO:0005515//GO:0016891 protein binding//endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG1882 Transcriptional regulator SNIP1, contains FHA domain Cluster-8309.49535 BP_3 31.98 0.64 2697 546676945 ERL87869.1 962 4.9e-101 hypothetical protein D910_05257 [Dendroctonus ponderosae] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50430 543 7.8e-54 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF00884//PF02319 Sulfatase//E2F/DP family winged-helix DNA-binding domain GO:0008152//GO:0006355 metabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0008484 transcription factor activity, sequence-specific DNA binding//sulfuric ester hydrolase activity GO:0005667 transcription factor complex -- -- Cluster-8309.49537 BP_3 404.37 8.85 2494 642912518 XP_008200898.1 3155 0.0e+00 PREDICTED: lysine-specific histone demethylase 1A [Tribolium castaneum] 831537284 XM_012867807.1 99 1.04273e-41 PREDICTED: Fundulus heteroclitus lysine (K)-specific demethylase 1A (kdm1a), transcript variant X2, mRNA K11450 KDM1A, AOF2, LSD1 lysine-specific histone demethylase 1A http://www.genome.jp/dbget-bin/www_bget?ko:K11450 O60341 2321 4.9e-260 Lysine-specific histone demethylase 1A OS=Homo sapiens GN=KDM1A PE=1 SV=2 PF01134//PF02826//PF00070//PF04433//PF01266//PF05834//PF02254//PF01593//PF12831//PF01494//PF07992//PF04799 Glucose inhibited division protein A//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//SWIRM domain//FAD dependent oxidoreductase//Lycopene cyclase protein//TrkA-N domain//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//fzo-like conserved region GO:0006813//GO:0055114//GO:0008033//GO:0008053//GO:0016117 potassium ion transport//oxidation-reduction process//tRNA processing//mitochondrial fusion//carotenoid biosynthetic process GO:0051287//GO:0003924//GO:0005515//GO:0016491//GO:0016705//GO:0071949//GO:0050660 NAD binding//GTPase activity//protein binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//flavin adenine dinucleotide binding GO:0016021//GO:0005741 integral component of membrane//mitochondrial outer membrane KOG0029 Amine oxidase Cluster-8309.49538 BP_3 14.89 0.45 1895 91087867 XP_969419.1 1924 9.8e-213 PREDICTED: histone deacetylase 3 [Tribolium castaneum]>gi|270012009|gb|EFA08457.1| hypothetical protein TcasGA2_TC006104 [Tribolium castaneum] 195568433 XM_002102185.1 235 1.97217e-117 Drosophila simulans GD19615 (Dsim\GD19615), mRNA K11404 HDAC3 histone deacetylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11404 Q6IRL9 1605 3.9e-177 Histone deacetylase 3 OS=Xenopus laevis GN=hdac3 PE=2 SV=2 -- -- GO:0070932//GO:0070933//GO:0006807//GO:0006355 histone H3 deacetylation//histone H4 deacetylation//nitrogen compound metabolic process//regulation of transcription, DNA-templated GO:0032041//GO:0046970//GO:0046969//GO:0097372 NAD-dependent histone deacetylase activity (H3-K14 specific)//NAD-dependent histone deacetylase activity (H4-K16 specific)//NAD-dependent histone deacetylase activity (H3-K9 specific)//NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0005634//GO:0000118 nucleus//histone deacetylase complex KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.49539 BP_3 57.01 0.37 7727 642927000 XP_008195098.1 2561 5.4e-286 PREDICTED: protein disabled isoform X1 [Tribolium castaneum]>gi|270010075|gb|EFA06523.1| hypothetical protein TcasGA2_TC009426 [Tribolium castaneum] -- -- -- -- -- K12475 DAB2 disabled homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12475 P98081 681 2.2e-69 Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 PF07415//PF00640//PF08416//PF14719 Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID) GO:0019042 viral latency GO:0005515 protein binding GO:0033644 host cell membrane KOG3535 Adaptor protein Disabled Cluster-8309.49540 BP_3 805.16 5.59 7236 642927006 XP_008195101.1 3700 0.0e+00 PREDICTED: protein disabled isoform X4 [Tribolium castaneum] -- -- -- -- -- K12475 DAB2 disabled homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12475 P98081 670 3.9e-68 Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 PF14719//PF00640//PF07415 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID)//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency GO:0005515 protein binding GO:0033644 host cell membrane KOG3535 Adaptor protein Disabled Cluster-8309.49542 BP_3 16.20 0.39 2269 642933365 XP_008197385.1 1572 7.7e-172 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49544 BP_3 18.45 0.98 1202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49546 BP_3 167.07 4.14 2235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49548 BP_3 800.39 3.05 12959 642927168 XP_008195164.1 970 2.8e-101 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47180 731 6.0e-75 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF16093//PF00295 Proteasome assembly chaperone 4//Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0043248//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//proteasome assembly//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.49549 BP_3 424.71 2.86 7445 332376741 AEE63510.1 1257 8.5e-135 unknown [Dendroctonus ponderosae] 665817218 XM_008559146.1 65 2.49654e-22 PREDICTED: Microplitis demolitor glycine N-methyltransferase-like (LOC103578165), mRNA K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q29513 847 1.2e-88 Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus GN=GNMT PE=2 SV=1 PF01135//PF05724//PF05175//PF01885//PF08241//PF01909//PF00076//PF09249//PF06220//PF01209 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain//RNA 2'-phosphotransferase, Tpt1 / KptA family//Methyltransferase domain//Nucleotidyltransferase domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA nucleotidyltransferase, second domain//U1 zinc finger//ubiE/COQ5 methyltransferase family GO:0008152//GO:0006464//GO:0006388//GO:0006479//GO:0046500//GO:0008033 metabolic process//cellular protein modification process//tRNA splicing, via endonucleolytic cleavage and ligation//protein methylation//S-adenosylmethionine metabolic process//tRNA processing GO:0004810//GO:0008757//GO:0016437//GO:0008168//GO:0016772//GO:0008270//GO:0003676//GO:0004719//GO:0016779 tRNA adenylyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//tRNA cytidylyltransferase activity//methyltransferase activity//transferase activity, transferring phosphorus-containing groups//zinc ion binding//nucleic acid binding//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//nucleotidyltransferase activity -- -- KOG2278 RNA:NAD 2'-phosphotransferase TPT1 Cluster-8309.49550 BP_3 138.60 3.63 2133 91092074 XP_971115.1 2139 1.3e-237 PREDICTED: uncharacterized protein LOC659745 [Tribolium castaneum]>gi|270004682|gb|EFA01130.1| hypothetical protein TcasGA2_TC010343 [Tribolium castaneum] 642917993 XM_966022.2 289 2.13207e-147 PREDICTED: Tribolium castaneum uncharacterized LOC659745 (LOC659745), mRNA K10480 BTBD8 BTB/POZ domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10480 Q5XKL5 386 9.9e-36 BTB/POZ domain-containing protein 8 OS=Homo sapiens GN=BTBD8 PE=2 SV=2 PF00651//PF05757 BTB/POZ domain//Oxygen evolving enhancer protein 3 (PsbQ) GO:0015979 photosynthesis GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0009523//GO:0009654//GO:0019898 photosystem II//photosystem II oxygen evolving complex//extrinsic component of membrane KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.49556 BP_3 51.27 11.42 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49557 BP_3 135.11 1.54 4519 91085249 XP_973267.1 1086 3.5e-115 PREDICTED: thioredoxin-related transmembrane protein 2 homolog [Tribolium castaneum]>gi|270009096|gb|EFA05544.1| hypothetical protein TcasGA2_TC015732 [Tribolium castaneum] 815899095 XM_012394754.1 156 3.9149e-73 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 3.2e-92 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00085//PF00149//PF02144//PF04139//PF04005 Thioredoxin//Calcineurin-like phosphoesterase//Repair protein Rad1/Rec1/Rad17//Rad9//Hus1-like protein GO:0006281//GO:0045454//GO:0000077 DNA repair//cell redox homeostasis//DNA damage checkpoint GO:0016787 hydrolase activity GO:0030896//GO:0005634 checkpoint clamp complex//nucleus KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.49559 BP_3 142.82 8.33 1118 332375811 AEE63046.1 936 2.1e-98 unknown [Dendroctonus ponderosae] 815899095 XM_012394754.1 159 2.03593e-75 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 7.9e-93 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.49560 BP_3 184.57 1.63 5736 642918049 XP_008198995.1 1794 3.5e-197 PREDICTED: ATP-dependent RNA helicase dbp2-like [Tribolium castaneum] 752889233 XM_011264255.1 203 3.71425e-99 PREDICTED: Camponotus floridanus probable ATP-dependent RNA helicase DDX17 (LOC105255133), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1428 4.0e-156 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF00270//PF00004//PF04851 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.49562 BP_3 617.00 12.01 2767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49566 BP_3 153.79 3.48 2419 642924086 XP_008194000.1 1470 5.5e-160 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q9VW47 725 5.5e-75 Mediator of RNA polymerase II transcription subunit 12 OS=Drosophila melanogaster GN=kto PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49569 BP_3 218.00 3.87 3006 307196370 EFN77965.1 169 4.9e-09 hypothetical protein EAI_12921, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49571 BP_3 72.93 0.40 9099 642916561 XP_008191701.1 2302 6.9e-256 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] 642916712 XM_001813000.2 329 5.34651e-169 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100141653), mRNA -- -- -- -- Q5T2T1 1155 2.9e-124 MAGUK p55 subfamily member 7 OS=Homo sapiens GN=MPP7 PE=1 SV=1 PF13180//PF05225//PF00018//PF14604//PF00595//PF00651 PDZ domain//helix-turn-helix, Psq domain//SH3 domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//BTB/POZ domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.49572 BP_3 507.81 4.67 5533 642932256 XP_008197035.1 1291 7.2e-139 PREDICTED: uncharacterized protein CG7065 homolog isoform X2 [Tribolium castaneum] 805785462 XM_012284975.1 63 2.39714e-21 PREDICTED: Megachile rotundata uncharacterized protein CG7065-like (LOC100874663), transcript variant X3, mRNA -- -- -- -- Q7YZA2 382 7.5e-35 Uncharacterized protein CG7065 OS=Drosophila melanogaster GN=CG7065 PE=1 SV=1 PF16554 Dimerisation domain of d-ornithine 4,5-aminomutase -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.49578 BP_3 77.44 4.01 1222 642933837 XP_008197529.1 190 7.4e-12 PREDICTED: epsin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49579 BP_3 1517.71 21.65 3671 478259957 ENN79759.1 1185 9.3e-127 hypothetical protein YQE_03815, partial [Dendroctonus ponderosae]>gi|546681505|gb|ERL91582.1| hypothetical protein D910_08912 [Dendroctonus ponderosae] -- -- -- -- -- K05614 SLC1A3, EAAT1 solute carrier family 1 (glial high affinity glutamate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05614 P24942 748 1.8e-77 Excitatory amino acid transporter 1 OS=Rattus norvegicus GN=Slc1a3 PE=1 SV=2 PF02535//PF01903//PF00375 ZIP Zinc transporter//CbiX//Sodium:dicarboxylate symporter family GO:0030001//GO:0055085//GO:0006783//GO:0009236//GO:0006820//GO:0006835//GO:0006812 metal ion transport//transmembrane transport//heme biosynthetic process//cobalamin biosynthetic process//anion transport//dicarboxylic acid transport//cation transport GO:0017153//GO:0016852//GO:0046873 sodium:dicarboxylate symporter activity//sirohydrochlorin cobaltochelatase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.49582 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49583 BP_3 388.89 4.48 4472 91081955 XP_967420.1 2620 4.5e-293 PREDICTED: cullin-3 [Tribolium castaneum]>gi|270007361|gb|EFA03809.1| hypothetical protein TcasGA2_TC013922 [Tribolium castaneum] 755982854 XM_011311736.1 332 5.62708e-171 PREDICTED: Fopius arisanus cullin-3 (LOC105270650), mRNA K03869 CUL3 cullin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03869 B5DF89 2168 4.8e-242 Cullin-3 OS=Rattus norvegicus GN=Cul3 PE=1 SV=2 PF02023//PF00888//PF12422 SCAN domain//Cullin family//Condensin II non structural maintenance of chromosomes subunit GO:0006511//GO:0006355 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0031625 transcription factor activity, sequence-specific DNA binding//ubiquitin protein ligase binding GO:0005667//GO:0005634//GO:0031461 transcription factor complex//nucleus//cullin-RING ubiquitin ligase complex KOG2166 Cullins Cluster-8309.49584 BP_3 321.10 1.88 8522 91085437 XP_968834.1 1008 7.2e-106 PREDICTED: protein zyg-11 homolog [Tribolium castaneum]>gi|270009168|gb|EFA05616.1| hypothetical protein TcasGA2_TC015823 [Tribolium castaneum] 462389525 APGK01019132.1 136 9.71867e-62 Dendroctonus ponderosae Seq01019142, whole genome shotgun sequence K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 A0JMZ3 586 2.6e-58 Protein zyg-11 homolog OS=Xenopus laevis GN=zyg-11 PE=2 SV=1 PF00514//PF00073//PF13855//PF08711//PF00560//PF02985 Armadillo/beta-catenin-like repeat//picornavirus capsid protein//Leucine rich repeat//TFIIS helical bundle-like domain//Leucine Rich Repeat//HEAT repeat GO:0006351 transcription, DNA-templated GO:0003677//GO:0005515//GO:0005198 DNA binding//protein binding//structural molecule activity GO:0005634//GO:0019028 nucleus//viral capsid KOG3665 ZYG-1-like serine/threonine protein kinases Cluster-8309.49587 BP_3 1.00 1.49 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49588 BP_3 34.00 73.80 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49589 BP_3 98.33 0.72 6863 766923639 XP_011506452.1 753 2.2e-76 PREDICTED: protein FAM102B [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- Q6GNM6 456 2.4e-43 Protein FAM102A OS=Xenopus laevis GN=fam102a PE=2 SV=1 PF07525//PF07660 SOCS box//Secretin and TonB N terminus short domain GO:0035556 intracellular signal transduction -- -- GO:0019867 outer membrane -- -- Cluster-8309.49590 BP_3 346.43 2.59 6728 642912146 XP_008200825.1 1113 3.8e-118 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNM6 504 6.5e-49 Protein FAM102A OS=Xenopus laevis GN=fam102a PE=2 SV=1 PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.49591 BP_3 123.90 1.16 5456 642912146 XP_008200825.1 635 8.3e-63 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.49593 BP_3 22.46 0.45 2691 332374548 AEE62415.1 509 1.7e-48 unknown [Dendroctonus ponderosae]>gi|478260072|gb|ENN79857.1| hypothetical protein YQE_03677, partial [Dendroctonus ponderosae]>gi|546676791|gb|ERL87737.1| hypothetical protein D910_05126 [Dendroctonus ponderosae] -- -- -- -- -- K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q95108 302 6.9e-26 Thioredoxin, mitochondrial OS=Bos taurus GN=TXN2 PE=1 SV=2 PF02966//PF01323//PF00085//PF08534//PF00462//PF07689 Mitosis protein DIM1//DSBA-like thioredoxin domain//Thioredoxin//Redoxin//Glutaredoxin//KaiB domain GO:0048511//GO:0000398//GO:0045454//GO:0006118 rhythmic process//mRNA splicing, via spliceosome//cell redox homeostasis//obsolete electron transport GO:0016491//GO:0015035//GO:0009055 oxidoreductase activity//protein disulfide oxidoreductase activity//electron carrier activity GO:0005681 spliceosomal complex KOG0910 Thioredoxin-like protein Cluster-8309.49595 BP_3 428.82 4.39 5003 642919677 XP_968051.2 1092 7.7e-116 PREDICTED: uncharacterized protein LOC656425 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VBW5 307 3.4e-26 HMG box transcription factor BBX OS=Mus musculus GN=Bbx PE=1 SV=2 PF13014//PF08785//PF00013//PF11520 KH domain//Ku C terminal domain like//KH domain//Chromatin protein Cren7 -- -- GO:0003690//GO:0016817//GO:0003723 double-stranded DNA binding//hydrolase activity, acting on acid anhydrides//RNA binding GO:0005737 cytoplasm KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.49596 BP_3 13.96 1.02 954 546677206 ERL88085.1 163 7.8e-09 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49597 BP_3 455.17 8.70 2812 546677626 ERL88431.1 2497 5.2e-279 hypothetical protein D910_05817, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VUY0 1367 2.3e-149 MOXD1 homolog 1 OS=Drosophila melanogaster GN=CG5235 PE=2 SV=2 PF01082//PF07465 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//Photosystem I protein M (PsaM) GO:0055114//GO:0015979 oxidation-reduction process//photosynthesis GO:0004497//GO:0016715//GO:0005507 monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//copper ion binding -- -- KOG3568 Dopamine beta-monooxygenase Cluster-8309.49598 BP_3 114.10 2.17 2829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49601 BP_3 277.37 2.89 4925 91086147 XP_969343.1 2917 0.0e+00 PREDICTED: integrator complex subunit 11 [Tribolium castaneum]>gi|270009886|gb|EFA06334.1| hypothetical protein TcasGA2_TC009205 [Tribolium castaneum] 826440986 XM_012674849.1 377 0 PREDICTED: Monomorium pharaonis integrator complex subunit 11 (LOC105833262), transcript variant X4, mRNA K13148 CPSF3L, INTS11 integrator complex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13148 Q5ZIH0 2284 1.9e-255 Integrator complex subunit 11 OS=Gallus gallus GN=CPSF3L PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.49602 BP_3 322.97 3.35 4938 91086147 XP_969343.1 2917 0.0e+00 PREDICTED: integrator complex subunit 11 [Tribolium castaneum]>gi|270009886|gb|EFA06334.1| hypothetical protein TcasGA2_TC009205 [Tribolium castaneum] 826440986 XM_012674849.1 377 0 PREDICTED: Monomorium pharaonis integrator complex subunit 11 (LOC105833262), transcript variant X4, mRNA K13148 CPSF3L, INTS11 integrator complex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13148 Q5ZIH0 2284 1.9e-255 Integrator complex subunit 11 OS=Gallus gallus GN=CPSF3L PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.49604 BP_3 43.00 0.70 3270 642937391 XP_008198818.1 551 2.7e-53 PREDICTED: carboxypeptidase N subunit 2-like [Tribolium castaneum]>gi|270001112|gb|EEZ97559.1| hypothetical protein TcasGA2_TC011413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02833 197 1.3e-13 Insulin-like growth factor-binding protein complex acid labile subunit OS=Papio hamadryas GN=IGFALS PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.49605 BP_3 1.62 5.51 276 546677909 ERL88653.1 190 1.6e-12 hypothetical protein D910_06037 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49607 BP_3 910.20 39.98 1389 91085415 XP_967672.1 937 2.0e-98 PREDICTED: ell-associated factor Eaf [Tribolium castaneum]>gi|642926746|ref|XP_008194996.1| PREDICTED: ell-associated factor Eaf [Tribolium castaneum]>gi|270009158|gb|EFA05606.1| hypothetical protein TcasGA2_TC015812 [Tribolium castaneum] 642926744 XM_962579.2 42 2.78714e-10 PREDICTED: Tribolium castaneum ell-associated factor Eaf (LOC656023), transcript variant X1, mRNA K15186 EAF ELL-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15186 B4P1N5 480 8.1e-47 Ell-associated factor Eaf OS=Drosophila yakuba GN=Eaf PE=3 SV=1 PF07943 Penicillin-binding protein 5, C-terminal domain GO:0006508 proteolysis GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity -- -- KOG4795 Protein associated with transcriptional elongation factor ELL Cluster-8309.49608 BP_3 104.82 0.42 12182 546678376 ERL89009.1 14244 0.0e+00 hypothetical protein D910_06387 [Dendroctonus ponderosae] 861437320 XM_013072408.1 160 6.33616e-75 PREDICTED: Heterocephalus glaber dynein, axonemal, heavy chain 5 (Dnah5), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q96JB1 10172 0.0e+00 Dynein heavy chain 8, axonemal OS=Homo sapiens GN=DNAH8 PE=1 SV=2 PF00004//PF03028//PF07728//PF11112//PF09520 ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor//AAA domain (dynein-related subfamily)//Pyocin activator protein PrtN//Type II restriction endonuclease, TdeIII GO:0007018//GO:0006355//GO:0007017//GO:0009307//GO:0006308 microtubule-based movement//regulation of transcription, DNA-templated//microtubule-based process//DNA restriction-modification system//DNA catabolic process GO:0005524//GO:0009036//GO:0003677//GO:0003777//GO:0016887 ATP binding//Type II site-specific deoxyribonuclease activity//DNA binding//microtubule motor activity//ATPase activity GO:0030286//GO:0005874//GO:0009359 dynein complex//microtubule//Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.49609 BP_3 327.00 2.89 5751 642938278 XP_008192712.1 3280 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938291 XM_008194530.1 978 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X9, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.3e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF07714//PF00069//PF12142 Protein tyrosine kinase//Protein kinase domain//Polyphenol oxidase middle domain GO:0006118//GO:0055114//GO:0006468//GO:0006570 obsolete electron transport//oxidation-reduction process//protein phosphorylation//tyrosine metabolic process GO:0005524//GO:0004097//GO:0004672 ATP binding//catechol oxidase activity//protein kinase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.49610 BP_3 71.00 1.25 3040 642930253 XP_008196317.1 1147 2.0e-122 PREDICTED: lachesin-like [Tribolium castaneum]>gi|642930255|ref|XP_008196318.1| PREDICTED: lachesin-like [Tribolium castaneum]>gi|642930257|ref|XP_008196319.1| PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49613 BP_3 198.85 2.67 3876 642914292 XP_008201625.1 1104 2.4e-117 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 O14733 934 5.1e-99 Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens GN=MAP2K7 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0983 Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2 Cluster-8309.49614 BP_3 5.31 0.45 859 642914292 XP_008201625.1 282 1.1e-22 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08935 Viral protein VP4 subunit -- -- -- -- GO:0019030 icosahedral viral capsid -- -- Cluster-8309.49615 BP_3 61.84 4.68 929 270006684 EFA03132.1 738 1.6e-75 hypothetical protein TcasGA2_TC013044 [Tribolium castaneum] 642924851 XM_008195844.1 184 2.1288e-89 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- Q9Y266 547 9.2e-55 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.49616 BP_3 155.78 6.66 1419 642914292 XP_008201625.1 1443 4.4e-157 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 O14733 1119 6.7e-121 Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens GN=MAP2K7 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0983 Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2 Cluster-8309.49617 BP_3 298.19 7.41 2231 642914292 XP_008201625.1 587 1.2e-57 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 Q23977 182 4.7e-12 Dual specificity mitogen-activated protein kinase kinase hemipterous OS=Drosophila melanogaster GN=hep PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49619 BP_3 21.04 6.64 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49620 BP_3 6.00 0.95 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49621 BP_3 242.00 9.79 1483 270008954 EFA05402.1 1409 4.0e-153 hypothetical protein TcasGA2_TC015574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49622 BP_3 6.00 0.66 732 478250699 ENN71191.1 204 1.1e-13 hypothetical protein YQE_12120, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49623 BP_3 125.40 0.96 6565 270010424 EFA06872.1 8503 0.0e+00 hypothetical protein TcasGA2_TC009817 [Tribolium castaneum] 642928920 XM_008197395.1 1349 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 4681 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF01080//PF02985//PF00443//PF05395 Presenilin//HEAT repeat//Ubiquitin carboxyl-terminal hydrolase//Protein phosphatase inhibitor 1/DARPP-32 GO:0007165//GO:0016579 signal transduction//protein deubiquitination GO:0036459//GO:0004864//GO:0004190//GO:0005515 ubiquitinyl hydrolase activity//protein phosphatase inhibitor activity//aspartic-type endopeptidase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.49624 BP_3 735.31 8.00 4720 189235385 XP_969534.2 4402 0.0e+00 PREDICTED: regulator of nonsense transcripts 2 [Tribolium castaneum] -- -- -- -- -- K14327 UPF2, RENT2 regulator of nonsense transcripts 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14327 Q9HAU5 2203 4.5e-246 Regulator of nonsense transcripts 2 OS=Homo sapiens GN=UPF2 PE=1 SV=1 PF02854 MIF4G domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2051 Nonsense-mediated mRNA decay 2 protein Cluster-8309.49625 BP_3 173.97 2.33 3889 642928921 XP_008195617.1 4891 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 1119 1.8e-120 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49626 BP_3 843.94 8.96 4834 91076220 XP_972698.1 3287 0.0e+00 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum]>gi|270014737|gb|EFA11185.1| hypothetical protein TcasGA2_TC004793 [Tribolium castaneum] 462373375 APGK01024771.1 206 6.71995e-101 Dendroctonus ponderosae Seq01024781, whole genome shotgun sequence K14353 SLCO3A solute carrier organic anion transporter family, member 3A http://www.genome.jp/dbget-bin/www_bget?ko:K14353 Q9H2Y9 912 2.3e-96 Solute carrier organic anion transporter family member 5A1 OS=Homo sapiens GN=SLCO5A1 PE=2 SV=2 PF07690//PF03137//PF00050//PF07648 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0055085//GO:0006810 transmembrane transport//transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.49627 BP_3 248.62 4.32 3066 282165752 NP_001164117.1 1291 4.0e-139 uncharacterized protein LOC100322888 [Tribolium castaneum]>gi|270013327|gb|EFA09775.1| hypothetical protein TcasGA2_TC011917 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49630 BP_3 1905.48 120.01 1057 -- -- -- -- -- 642916845 XM_008201305.1 130 2.53876e-59 PREDICTED: Tribolium castaneum failed axon connections (LOC656797), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49633 BP_3 21.83 0.69 1811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-8309.49634 BP_3 66.28 3.58 1184 156546413 XP_001607107.1 442 4.3e-41 PREDICTED: pyridoxal kinase isoform X2 [Nasonia vitripennis] -- -- -- -- -- K00868 pdxK, pdxY pyridoxine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00868 Q8W1X2 370 3.9e-34 Pyridoxal kinase OS=Arabidopsis thaliana GN=PK PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2599 Pyridoxal/pyridoxine/pyridoxamine kinase Cluster-8309.49637 BP_3 737.78 10.63 3638 91076374 XP_967954.1 2668 1.0e-298 PREDICTED: DNA ligase 3 [Tribolium castaneum]>gi|270002897|gb|EEZ99344.1| ligase III [Tribolium castaneum] -- -- -- -- -- K10776 LIG3 DNA ligase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10776 P49916 2093 2.0e-233 DNA ligase 3 OS=Homo sapiens GN=LIG3 PE=1 SV=2 PF04675//PF04679//PF02229//PF01068//PF00645 DNA ligase N terminus//ATP dependent DNA ligase C terminal region//Transcriptional Coactivator p15 (PC4)//ATP dependent DNA ligase domain//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0006281//GO:0006260//GO:0006355//GO:0006310 DNA repair//DNA replication//regulation of transcription, DNA-templated//DNA recombination GO:0003677//GO:0005524//GO:0003713//GO:0003909//GO:0000166//GO:0008270//GO:0043167//GO:0003910 DNA binding//ATP binding//transcription coactivator activity//DNA ligase activity//nucleotide binding//zinc ion binding//ion binding//DNA ligase (ATP) activity GO:0005667 transcription factor complex KOG0967 ATP-dependent DNA ligase I Cluster-8309.49640 BP_3 72.88 1.57 2525 91080515 XP_971732.1 844 2.2e-87 PREDICTED: galectin-8-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00214 373 3.8e-34 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.49644 BP_3 657.00 10.40 3336 270007486 EFA03934.1 2860 0.0e+00 hypothetical protein TcasGA2_TC014074 [Tribolium castaneum] -- -- -- -- -- K18643 KATNB1 katanin p80 WD40 repeat-containing subunit B1 http://www.genome.jp/dbget-bin/www_bget?ko:K18643 O61585 1038 3.9e-111 Katanin p80 WD40 repeat-containing subunit B1 OS=Strongylocentrotus purpuratus GN=KATNB1 PE=1 SV=1 PF13931//PF00400 Kinesin-associated microtubule-binding//WD domain, G-beta repeat -- -- GO:0008017//GO:0005515 microtubule binding//protein binding GO:0045298 tubulin complex KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats) Cluster-8309.49647 BP_3 121.73 5.15 1430 189238013 XP_001813375.1 1388 1.0e-150 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 55 1.70394e-17 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 934 1.9e-99 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00664 ABC transporter transmembrane region GO:0006810//GO:0006200//GO:0055085 transport//obsolete ATP catabolic process//transmembrane transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.49648 BP_3 67.52 2.97 1388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02790 Cytochrome C oxidase subunit II, transmembrane domain GO:0022900 electron transport chain -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.4965 BP_3 7.00 0.58 871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49651 BP_3 25.00 0.67 2099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49652 BP_3 204.45 3.78 2896 642921163 XP_008192741.1 2292 3.2e-255 PREDICTED: sip1/TFIP11 interacting protein isoform X1 [Tribolium castaneum]>gi|270006305|gb|EFA02753.1| hypothetical protein TcasGA2_TC008486 [Tribolium castaneum] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q0IIX9 1226 5.3e-133 Tuftelin-interacting protein 11 OS=Xenopus tropicalis GN=tfip11 PE=2 SV=2 PF07842//PF01585 GC-rich sequence DNA-binding factor-like protein//G-patch domain GO:0008380//GO:0006355//GO:0006397 RNA splicing//regulation of transcription, DNA-templated//mRNA processing GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0005681//GO:0005634 spliceosomal complex//nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.49653 BP_3 150.34 2.64 3039 122114669 NP_001073624.1 2891 0.0e+00 Sip1/TFIP11 interacting protein [Tribolium castaneum]>gi|85363108|gb|ABC69932.1| STIP [Tribolium castaneum] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q6DI35 1457 9.1e-160 Tuftelin-interacting protein 11 OS=Danio rerio GN=tfip11 PE=1 SV=1 PF07842//PF01585 GC-rich sequence DNA-binding factor-like protein//G-patch domain GO:0006397//GO:0006355//GO:0008380 mRNA processing//regulation of transcription, DNA-templated//RNA splicing GO:0003677//GO:0003676 DNA binding//nucleic acid binding GO:0005634//GO:0005681 nucleus//spliceosomal complex KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.49654 BP_3 30.57 0.78 2173 478259929 ENN79731.1 1251 1.2e-134 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U2U7 617 1.7e-62 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF02285//PF12326//PF09243 Cytochrome oxidase c subunit VIII//N-glycosylation protein//Mitochondrial small ribosomal subunit Rsm22 GO:0034599//GO:0015992//GO:0006123//GO:0006412 cellular response to oxidative stress//proton transport//mitochondrial electron transport, cytochrome c to oxygen//translation GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0005789//GO:0045277 endoplasmic reticulum membrane//respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.49656 BP_3 378.13 6.49 3102 642939784 XP_970158.2 1230 4.8e-132 PREDICTED: mesoderm induction early response protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T105 566 1.9e-56 Mesoderm induction early response protein 1 OS=Xenopus laevis GN=mier1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.49658 BP_3 194.60 2.00 4991 390362249 XP_001190749.2 1582 1.2e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 2.8e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00906//PF00023//PF00866//PF01637//PF13606 Hepatitis core antigen//Ankyrin repeat//Ring hydroxylating beta subunit//Archaeal ATPase//Ankyrin repeat GO:0055114//GO:0006725//GO:0009405 oxidation-reduction process//cellular aromatic compound metabolic process//pathogenesis GO:0005198//GO:0005515//GO:0005524//GO:0003824 structural molecule activity//protein binding//ATP binding//catalytic activity -- -- -- -- Cluster-8309.49659 BP_3 48.35 3.41 976 642926735 XP_008194991.1 353 7.4e-31 PREDICTED: protein Malvolio isoform X3 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 180 3.5e-12 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF01384//PF15168//PF07123//PF08395 Phosphate transporter family//Triple QxxK/R motif-containing protein family//Photosystem II reaction centre W protein (PsbW)//7tm Chemosensory receptor GO:0015979//GO:0006817//GO:0050909 photosynthesis//phosphate ion transport//sensory perception of taste GO:0005315 inorganic phosphate transmembrane transporter activity GO:0016021//GO:0005789//GO:0009507//GO:0016020//GO:0009523 integral component of membrane//endoplasmic reticulum membrane//chloroplast//membrane//photosystem II -- -- Cluster-8309.4966 BP_3 12.00 0.69 1135 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49660 BP_3 12.81 0.50 1515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49661 BP_3 42.00 0.75 2987 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49662 BP_3 81.43 0.71 5791 270009582 EFA06030.1 3211 0.0e+00 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] 749781041 XM_011146561.1 110 1.87265e-47 PREDICTED: Harpegnathos saltator uncharacterized LOC105186395 (LOC105186395), mRNA K05725 PTK2, FAK focal adhesion kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05725 Q05397 1800 2.9e-199 Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2 PF00069//PF07714//PF03623 Protein kinase domain//Protein tyrosine kinase//Focal adhesion targeting region GO:0007165//GO:0007172//GO:0006468 signal transduction//signal complex assembly//protein phosphorylation GO:0004713//GO:0005524//GO:0004871//GO:0004672 protein tyrosine kinase activity//ATP binding//signal transducer activity//protein kinase activity GO:0005925 focal adhesion KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain Cluster-8309.49663 BP_3 508.55 4.43 5819 270009582 EFA06030.1 3434 0.0e+00 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] 749781041 XM_011146561.1 110 1.88176e-47 PREDICTED: Harpegnathos saltator uncharacterized LOC105186395 (LOC105186395), mRNA K05725 PTK2, FAK focal adhesion kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05725 Q05397 1800 3.0e-199 Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2 PF00069//PF03623//PF07714 Protein kinase domain//Focal adhesion targeting region//Protein tyrosine kinase GO:0006468//GO:0007172//GO:0007165 protein phosphorylation//signal complex assembly//signal transduction GO:0004713//GO:0005524//GO:0004672//GO:0004871 protein tyrosine kinase activity//ATP binding//protein kinase activity//signal transducer activity GO:0005925 focal adhesion KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain Cluster-8309.49665 BP_3 132.00 2.09 3342 270010224 EFA06672.1 3668 0.0e+00 hypothetical protein TcasGA2_TC009600 [Tribolium castaneum] -- -- -- -- -- K02324 POLE1 DNA polymerase epsilon subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02324 Q9WVF7 2204 2.4e-246 DNA polymerase epsilon catalytic subunit A OS=Mus musculus GN=Pole PE=2 SV=3 PF05280//PF08490 Flagellar transcriptional activator (FlhC)//Domain of unknown function (DUF1744) GO:0045893//GO:1902208//GO:0006260 positive regulation of transcription, DNA-templated//regulation of bacterial-type flagellum assembly//DNA replication GO:0003677//GO:0003887//GO:0008270 DNA binding//DNA-directed DNA polymerase activity//zinc ion binding GO:0005634//GO:0042575 nucleus//DNA polymerase complex KOG1798 DNA polymerase epsilon, catalytic subunit A Cluster-8309.49668 BP_3 128.86 1.44 4617 478253546 ENN73864.1 968 1.7e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.38586e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 8.9e-82 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF01529 Peptidase family M50//DHHC palmitoyltransferase GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG2585 Uncharacterized conserved protein Cluster-8309.49669 BP_3 50.18 1.86 1590 642924008 XP_008193967.1 180 1.4e-10 PREDICTED: ran-binding protein 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0005634//GO:0000775 nucleus//chromosome, centromeric region -- -- Cluster-8309.49672 BP_3 350.83 7.56 2528 270014679 EFA11127.1 658 8.2e-66 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 300 1.1e-25 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49673 BP_3 102.76 2.09 2667 478254798 ENN75034.1 1439 2.4e-156 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 167 1.76485e-79 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 980 1.6e-104 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF03526 Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex KOG3530 FERM domain protein EHM2 Cluster-8309.49676 BP_3 1.00 0.41 409 260810939 XP_002600180.1 214 4.0e-15 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9H4Z2 128 1.6e-06 Zinc finger protein 335 OS=Homo sapiens GN=ZNF335 PE=1 SV=1 PF07562//PF00130//PF13465//PF00096 Nine Cysteines Domain of family 3 GPCR//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0007186//GO:0035556 G-protein coupled receptor signaling pathway//intracellular signal transduction GO:0004930//GO:0046872 G-protein coupled receptor activity//metal ion binding -- -- -- -- Cluster-8309.49677 BP_3 1054.73 11.59 4677 728417025 AIY68331.1 3720 0.0e+00 putative gliotactin [Leptinotarsa decemlineata] 645019941 XM_008208782.1 61 2.61802e-20 PREDICTED: Nasonia vitripennis gliotactin (LOC100120557), transcript variant X3, mRNA -- -- -- -- Q69ZK9 628 1.9e-63 Neuroligin-2 OS=Mus musculus GN=Nlgn2 PE=1 SV=2 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.4968 BP_3 1.00 0.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49680 BP_3 180.00 12.57 982 270013391 EFA09839.1 1541 1.3e-168 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 220 8.1e-17 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.49681 BP_3 42.03 0.33 6476 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.3246e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.3e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF00787//PF00018//PF14604//PF00620//PF01929 PX domain//SH3 domain//Variant SH3 domain//RhoGAP domain//Ribosomal protein L14 GO:0007154//GO:0042254//GO:0006412//GO:0007165 cell communication//ribosome biogenesis//translation//signal transduction GO:0003735//GO:0035091//GO:0005515 structural constituent of ribosome//phosphatidylinositol binding//protein binding GO:0005840//GO:0005622 ribosome//intracellular KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.49682 BP_3 1.00 5.73 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49683 BP_3 223.91 6.80 1880 478255819 ENN76027.1 855 8.8e-89 hypothetical protein YQE_07403, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.49686 BP_3 40.87 1.24 1880 478267740 ENN83098.1 409 4.6e-37 hypothetical protein YQE_00541, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BN95 185 1.8e-12 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49688 BP_3 472.80 2.97 7971 189236343 XP_975398.2 2270 3.1e-252 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X3 [Tribolium castaneum] 642919611 XM_008193717.1 100 9.34839e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.7e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF01388//PF12031//PF02257 ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518)//RFX DNA-binding domain GO:0006355//GO:0006338 regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.49689 BP_3 40.30 6.34 598 91086889 XP_970389.1 228 1.4e-16 PREDICTED: lipoma HMGIC fusion partner-like 2 protein [Tribolium castaneum]>gi|642929193|ref|XP_008195730.1| PREDICTED: lipoma HMGIC fusion partner-like 2 protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49691 BP_3 180.95 2.62 3622 642917011 XP_008199595.1 1252 1.6e-134 PREDICTED: probable ATP-dependent RNA helicase DHX35 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O77475 954 2.3e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF01066//PF04548//PF00503//PF00437//PF03193//PF00005 CDP-alcohol phosphatidyltransferase//AIG1 family//G-protein alpha subunit//Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0007165//GO:0008654//GO:0007186 transport//signal transduction//phospholipid biosynthetic process//G-protein coupled receptor signaling pathway GO:0003924//GO:0016780//GO:0005524//GO:0031683//GO:0005525//GO:0004871//GO:0019001//GO:0016887 GTPase activity//phosphotransferase activity, for other substituted phosphate groups//ATP binding//G-protein beta/gamma-subunit complex binding//GTP binding//signal transducer activity//guanyl nucleotide binding//ATPase activity GO:0016020 membrane KOG0922 DEAH-box RNA helicase Cluster-8309.49693 BP_3 29.89 0.49 3257 642917000 XP_008199589.1 225 1.7e-15 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00317 Ribonucleotide reductase, all-alpha domain GO:0006260//GO:0006206//GO:0055114//GO:0009186//GO:0006144 DNA replication//pyrimidine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process GO:0005524//GO:0004748 ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-8309.49697 BP_3 179.39 1.27 7087 91078242 XP_970298.1 3529 0.0e+00 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 642939064 XM_008201985.1 402 0 PREDICTED: Tribolium castaneum xenotropic and polytropic retrovirus receptor 1 (LOC100142189), transcript variant X2, mRNA -- -- -- -- Q9UBH6 1815 6.6e-201 Xenotropic and polytropic retrovirus receptor 1 OS=Homo sapiens GN=XPR1 PE=1 SV=1 PF01504//PF03124 Phosphatidylinositol-4-phosphate 5-Kinase//EXS family GO:0046488 phosphatidylinositol metabolic process GO:0016307//GO:0043167 phosphatidylinositol phosphate kinase activity//ion binding GO:0016021 integral component of membrane KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.49698 BP_3 253.44 6.26 2244 91078242 XP_970298.1 2598 8.1e-291 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 462322709 APGK01042728.1 101 7.24129e-43 Dendroctonus ponderosae Seq01042738, whole genome shotgun sequence K00921 PIKFYVE, FAB1 1-phosphatidylinositol-3-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00921 Q9Z1T6 1105 4.4e-119 1-phosphatidylinositol 3-phosphate 5-kinase OS=Mus musculus GN=Pikfyve PE=1 SV=3 PF00118//PF00610//PF00851//PF01363 TCP-1/cpn60 chaperonin family//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Helper component proteinase//FYVE zinc finger GO:0006508//GO:0035556//GO:0046854//GO:0044267 proteolysis//intracellular signal transduction//phosphatidylinositol phosphorylation//cellular protein metabolic process GO:0016307//GO:0004197//GO:0046872//GO:0005524 phosphatidylinositol phosphate kinase activity//cysteine-type endopeptidase activity//metal ion binding//ATP binding GO:0005622 intracellular KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.49699 BP_3 103.92 1.72 3196 189235866 XP_969616.2 3011 0.0e+00 PREDICTED: pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [Tribolium castaneum]>gi|270004535|gb|EFA00983.1| hypothetical protein TcasGA2_TC003896 [Tribolium castaneum] 242012722 XM_002427032.1 375 0 Pediculus humanus corporis splicing factor ATP-dependent RNA helicase prp16, putative, mRNA K12815 DHX38, PRP16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 http://www.genome.jp/dbget-bin/www_bget?ko:K12815 Q17R09 2191 7.4e-245 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Bos taurus GN=DHX38 PE=2 SV=1 PF02562//PF01637//PF00005//PF00931//PF00270//PF07652//PF02407//PF00158//PF00448//PF00437 PhoH-like protein//Archaeal ATPase//ABC transporter//NB-ARC domain//DEAD/DEAH box helicase//Flavivirus DEAD domain//Putative viral replication protein//Sigma-54 interaction domain//SRP54-type protein, GTPase domain//Type II/IV secretion system protein GO:0006144//GO:0006308//GO:0019079//GO:0006614//GO:0006810//GO:0018142//GO:0006260//GO:0006355 purine nucleobase metabolic process//DNA catabolic process//viral genome replication//SRP-dependent cotranslational protein targeting to membrane//transport//protein-DNA covalent cross-linking//DNA replication//regulation of transcription, DNA-templated GO:0004386//GO:0016888//GO:0043531//GO:0008026//GO:0003676//GO:0042624//GO:0005525//GO:0005524//GO:0008134//GO:0016887//GO:0000166//GO:0016779 helicase activity//endodeoxyribonuclease activity, producing 5'-phosphomonoesters//ADP binding//ATP-dependent helicase activity//nucleic acid binding//ATPase activity, uncoupled//GTP binding//ATP binding//transcription factor binding//ATPase activity//nucleotide binding//nucleotidyltransferase activity GO:0005667 transcription factor complex KOG0924 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.49700 BP_3 149.28 2.29 3434 642927046 XP_008195117.1 2581 1.2e-288 PREDICTED: putative ATP-dependent RNA helicase DHX30 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13185 DHX30 ATP-dependent RNA helicase DHX30 http://www.genome.jp/dbget-bin/www_bget?ko:K13185 Q5ZI74 1067 1.7e-114 Putative ATP-dependent RNA helicase DHX30 OS=Gallus gallus GN=DHX30 PE=2 SV=1 PF03193//PF04408//PF00270 Protein of unknown function, DUF258//Helicase associated domain (HA2)//DEAD/DEAH box helicase -- -- GO:0003924//GO:0003676//GO:0004386//GO:0005524//GO:0005525 GTPase activity//nucleic acid binding//helicase activity//ATP binding//GTP binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.49701 BP_3 43.30 0.81 2873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49702 BP_3 75.04 2.53 1720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49703 BP_3 26.65 1.12 1440 478250432 ENN70927.1 363 7.6e-32 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 290 9.1e-25 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3573 Caspase, apoptotic cysteine protease Cluster-8309.49704 BP_3 54.36 1.66 1873 642921248 XP_969543.2 768 1.1e-78 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 Q7KQM6 245 2.0e-19 PERQ amino acid-rich with GYF domain-containing protein CG11148 OS=Drosophila melanogaster GN=CG11148 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49711 BP_3 12.54 0.37 1905 123482337 XP_001323756.1 221 2.9e-15 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121906627|gb|EAY11533.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K06694 PSMD10 26S proteasome non-ATPase regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06694 Q4UMH6 181 5.2e-12 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00340 Ankyrin repeat//Interleukin-1 / 18 -- -- GO:0005515 protein binding GO:0005615 extracellular space -- -- Cluster-8309.49712 BP_3 25.68 0.92 1640 123482337 XP_001323756.1 242 9.2e-18 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121906627|gb|EAY11533.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q9EP71 189 5.3e-13 Ankycorbin OS=Mus musculus GN=Rai14 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.49715 BP_3 198.83 2.39 4308 478261443 ENN80813.1 1898 2.3e-209 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] 462382197 APGK01021748.1 140 2.92506e-64 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 1081 5.2e-116 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.49716 BP_3 71.85 0.85 4343 478261443 ENN80813.1 1898 2.3e-209 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] 462382197 APGK01021748.1 140 2.94902e-64 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 1081 5.2e-116 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.49717 BP_3 699.15 11.87 3130 91094507 XP_971663.1 1499 3.1e-163 PREDICTED: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [Tribolium castaneum]>gi|270000751|gb|EEZ97198.1| hypothetical protein TcasGA2_TC004386 [Tribolium castaneum] -- -- -- -- -- K00166 BCKDHA, bkdA1 2-oxoisovalerate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00166 Q8HXY4 1341 2.7e-146 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Macaca fascicularis GN=BCKDHA PE=2 SV=1 PF00676//PF02775//PF13292 Dehydrogenase E1 component//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694//GO:0008152 terpenoid biosynthetic process//steroid biosynthetic process//metabolic process GO:0030976//GO:0008661//GO:0016624//GO:0003824 thiamine pyrophosphate binding//1-deoxy-D-xylulose-5-phosphate synthase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity -- -- KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.49719 BP_3 65.86 1.08 3221 270014279 EFA10727.1 1613 1.9e-176 cappuccino [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 781 2.4e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.4972 BP_3 2.00 1.13 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49720 BP_3 610.00 35.50 1120 332372686 AEE61485.1 1029 3.5e-109 unknown [Dendroctonus ponderosae]>gi|478255312|gb|ENN75538.1| hypothetical protein YQE_07881, partial [Dendroctonus ponderosae]>gi|546683134|gb|ERL92985.1| hypothetical protein D910_10288 [Dendroctonus ponderosae] 268557825 XM_002636857.1 54 4.77246e-17 Caenorhabditis briggsae C. briggsae CBR-PAS-6 protein (Cbr-pas-6) mRNA, partial cds K02725 PSMA1 20S proteasome subunit alpha 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02725 Q9R1P4 832 1.0e-87 Proteasome subunit alpha type-1 OS=Mus musculus GN=Psma1 PE=1 SV=1 PF00227//PF10584 Proteasome subunit//Proteasome subunit A N-terminal signature GO:0006511//GO:0051603 ubiquitin-dependent protein catabolic process//proteolysis involved in cellular protein catabolic process GO:0004175//GO:0004298 endopeptidase activity//threonine-type endopeptidase activity GO:0005839//GO:0019773 proteasome core complex//proteasome core complex, alpha-subunit complex KOG0863 20S proteasome, regulatory subunit alpha type PSMA1/PRE5 Cluster-8309.49722 BP_3 67.66 0.37 9026 642934043 XP_008197617.1 532 1.2e-50 PREDICTED: kelch-like protein 38 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9J569 208 1.8e-14 Putative ankyrin repeat protein FPV162 OS=Fowlpox virus (strain NVSL) GN=FPV162 PE=3 SV=1 PF13606//PF01370//PF00023//PF00651//PF07646//PF01344 Ankyrin repeat//NAD dependent epimerase/dehydratase family//Ankyrin repeat//BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0003824//GO:0050662//GO:0005515 catalytic activity//coenzyme binding//protein binding -- -- KOG4177 Ankyrin Cluster-8309.49724 BP_3 213.09 2.74 4038 642938312 XP_008192824.1 857 1.1e-88 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X6 [Tribolium castaneum] 642938311 XM_008194602.1 163 4.48901e-77 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X7, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 Q9VWW0 285 9.7e-24 Cyclic AMP response element-binding protein B OS=Drosophila melanogaster GN=CrebB PE=1 SV=1 PF03131//PF00170//PF07716//PF02173 bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper//pKID domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.49726 BP_3 3244.97 62.33 2801 91078176 XP_967241.1 2271 8.4e-253 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 1711 3.0e-189 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- GO:0006979//GO:0006804//GO:0055114 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004601//GO:0020037 peroxidase activity//heme binding -- -- -- -- Cluster-8309.49727 BP_3 2.00 13.56 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04577 Protein of unknown function (DUF563) -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.49728 BP_3 1.00 1.52 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49732 BP_3 633.66 10.21 3282 91090264 XP_970269.1 888 2.3e-92 PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934841|ref|XP_008197832.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934843|ref|XP_008197833.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934845|ref|XP_008197834.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|270013784|gb|EFA10232.1| hypothetical protein TcasGA2_TC012429 [Tribolium castaneum] 780638303 XM_011689036.1 101 1.06373e-42 PREDICTED: Wasmannia auropunctata E3 ubiquitin-protein ligase RNF185-like (LOC105449687), transcript variant X4, mRNA K10666 RNF5 E3 ubiquitin-protein ligase RNF5 http://www.genome.jp/dbget-bin/www_bget?ko:K10666 Q5ZIR9 677 2.8e-69 E3 ubiquitin-protein ligase RNF185 OS=Gallus gallus GN=RNF185 PE=2 SV=1 PF13639//PF17123//PF12678//PF12861//PF14634//PF00219//PF00097 Ring finger domain//RING-like zinc finger//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Insulin-like growth factor binding protein//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0001558 protein ubiquitination//regulation of cell growth GO:0005520//GO:0005515//GO:0004842//GO:0008270//GO:0046872 insulin-like growth factor binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding//metal ion binding GO:0016942//GO:0005680//GO:0005576 insulin-like growth factor binding protein complex//anaphase-promoting complex//extracellular region KOG0823 Predicted E3 ubiquitin ligase Cluster-8309.49741 BP_3 217.09 4.03 2886 478260286 ENN80038.1 1121 1.9e-119 hypothetical protein YQE_03515, partial [Dendroctonus ponderosae] -- -- -- -- -- K03660 OGG1 N-glycosylase/DNA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K03660 O70249 689 9.8e-71 N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1 PF13895//PF07934//PF00730//PF00633 Immunoglobulin domain//8-oxoguanine DNA glycosylase, N-terminal domain//HhH-GPD superfamily base excision DNA repair protein//Helix-hairpin-helix motif GO:0006289//GO:0006308//GO:0006285//GO:0006281//GO:0006284 nucleotide-excision repair//DNA catabolic process//base-excision repair, AP site formation//DNA repair//base-excision repair GO:0003684//GO:0008534//GO:0005515//GO:0003677 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//protein binding//DNA binding -- -- KOG2875 8-oxoguanine DNA glycosylase Cluster-8309.49745 BP_3 6.00 0.36 1085 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49754 BP_3 49.52 1.01 2662 642919697 XP_008192026.1 1931 2.1e-213 PREDICTED: putative ATP-dependent RNA helicase DHX57 [Tribolium castaneum]>gi|270005433|gb|EFA01881.1| hypothetical protein TcasGA2_TC007486 [Tribolium castaneum] -- -- -- -- -- K13026 DHX57 ATP-dependent RNA helicase DHX57 http://www.genome.jp/dbget-bin/www_bget?ko:K13026 Q6P158 776 7.4e-81 Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens GN=DHX57 PE=1 SV=2 PF01609//PF00270//PF00437//PF05773//PF00642//PF00005 Transposase DDE domain//DEAD/DEAH box helicase//Type II/IV secretion system protein//RWD domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//ABC transporter GO:0006313//GO:0006810 transposition, DNA-mediated//transport GO:0005524//GO:0003677//GO:0008026//GO:0005515//GO:0008270//GO:0003676//GO:0016887//GO:0004803//GO:0046872 ATP binding//DNA binding//ATP-dependent helicase activity//protein binding//zinc ion binding//nucleic acid binding//ATPase activity//transposase activity//metal ion binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.49757 BP_3 60.46 0.96 3315 478251474 ENN71937.1 307 5.4e-25 hypothetical protein YQE_11371, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF03233//PF09367 THAP domain//Aphid transmission protein//CpeS-like protein GO:0017009//GO:0019089 protein-phycocyanobilin linkage//transmission of virus GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.49761 BP_3 303.15 5.64 2881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49763 BP_3 124.85 3.47 2027 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49764 BP_3 25.39 0.60 2318 270004815 EFA01263.1 788 6.4e-81 ftz transcription factor 1 [Tribolium castaneum] 642917896 XM_008193152.1 303 3.82776e-155 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 647 5.9e-66 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF09412//PF00288//PF00104 Endoribonuclease XendoU//GHMP kinases N terminal domain//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0016788 ATP binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.49765 BP_3 212.00 5.12 2288 91089021 XP_968771.1 1518 1.4e-165 PREDICTED: peptidyl-prolyl cis-trans isomerase-like 4 [Tribolium castaneum]>gi|270011537|gb|EFA07985.1| hypothetical protein TcasGA2_TC005570 [Tribolium castaneum] 665815434 XM_008558152.1 39 2.1577e-08 PREDICTED: Microplitis demolitor peptidyl-prolyl cis-trans isomerase-like 4 (LOC103577497), mRNA K12735 PPIL4 peptidyl-prolyl cis-trans isomerase-like 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12735 Q8WUA2 1130 5.7e-122 Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens GN=PPIL4 PE=1 SV=1 PF00160//PF00076 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0000413//GO:0044267//GO:0006457 protein peptidyl-prolyl isomerization//cellular protein metabolic process//protein folding GO:1901363//GO:0003676//GO:0097159//GO:0003755//GO:0016853 heterocyclic compound binding//nucleic acid binding//organic cyclic compound binding//peptidyl-prolyl cis-trans isomerase activity//isomerase activity -- -- KOG0415 Predicted peptidyl prolyl cis-trans isomerase Cluster-8309.49771 BP_3 47.22 0.39 6170 91095163 XP_968103.1 1706 6.0e-187 PREDICTED: phosphorylated CTD-interacting factor 1 [Tribolium castaneum]>gi|270015787|gb|EFA12235.1| hypothetical protein TcasGA2_TC004110 [Tribolium castaneum] -- -- -- -- -- K17584 PCIF1 phosphorylated CTD-interacting factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17584 Q9H4Z3 872 1.3e-91 Phosphorylated CTD-interacting factor 1 OS=Homo sapiens GN=PCIF1 PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49772 BP_3 61.06 1.03 3155 642927886 XP_001813556.2 1242 2.0e-133 PREDICTED: follistatin [Tribolium castaneum] -- -- -- -- -- K04661 FST follistatin http://www.genome.jp/dbget-bin/www_bget?ko:K04661 P31514 642 3.0e-65 Follistatin (Fragment) OS=Ovis aries GN=FST PE=2 SV=1 PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.49774 BP_3 22.21 2.03 818 91078712 XP_966534.1 541 9.8e-53 PREDICTED: ethanolamine-phosphate cytidylyltransferase [Tribolium castaneum]>gi|270003752|gb|EFA00200.1| hypothetical protein TcasGA2_TC003025 [Tribolium castaneum] -- -- -- -- -- K00967 PCYT2 ethanolamine-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00967 Q5EA75 432 1.8e-41 Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus GN=PCYT2 PE=2 SV=1 PF01467 Cytidylyltransferase-like GO:0009058 biosynthetic process GO:0003824//GO:0016779 catalytic activity//nucleotidyltransferase activity -- -- KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-8309.49777 BP_3 2771.77 11.61 11802 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 800 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.1e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF06743//PF01017//PF03124//PF01436//PF14634//PF00643//PF00097 FAST kinase-like protein, subdomain 1//STAT protein, all-alpha domain//EXS family//NHL repeat//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0008270//GO:0004871//GO:0003700//GO:0046872//GO:0004672 protein binding//zinc ion binding//signal transducer activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//protein kinase activity GO:0016021//GO:0005667//GO:0005622 integral component of membrane//transcription factor complex//intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.49778 BP_3 23.88 0.40 3204 642927083 XP_008195130.1 3664 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927082 XM_008196908.1 494 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X1, mRNA -- -- -- -- Q9ULI1 406 7.1e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF00004//PF07728//PF00931//PF00910//PF03193//PF00005//PF00006//PF04851//PF01637 ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//NB-ARC domain//RNA helicase//Protein of unknown function, DUF258//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//Type III restriction enzyme, res subunit//Archaeal ATPase -- -- GO:0003924//GO:0043531//GO:0016787//GO:0003677//GO:0005524//GO:0003723//GO:0003724//GO:0016887//GO:0005525 GTPase activity//ADP binding//hydrolase activity//DNA binding//ATP binding//RNA binding//RNA helicase activity//ATPase activity//GTP binding -- -- -- -- Cluster-8309.49779 BP_3 10.00 3.16 444 -- -- -- -- -- 768311754 CP010982.1 258 7.14358e-131 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49781 BP_3 28.93 0.39 3832 642935735 XP_008198150.1 2616 1.1e-292 PREDICTED: RNA polymerase II-associated protein 1 [Tribolium castaneum]>gi|270013972|gb|EFA10420.1| hypothetical protein TcasGA2_TC012660 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JN53 385 2.3e-35 RNA polymerase II-associated protein 1 OS=Bos taurus GN=RPAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4732 Uncharacterized conserved protein Cluster-8309.49782 BP_3 22.95 0.53 2394 662210206 XP_008478733.1 255 4.2e-19 PREDICTED: sporozoite surface protein 2-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49783 BP_3 47.16 1.08 2392 91084077 XP_968062.1 632 8.1e-63 PREDICTED: protein odr-4 homolog [Tribolium castaneum]>gi|270008008|gb|EFA04456.1| hypothetical protein TcasGA2_TC014760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWX8 234 4.7e-18 Protein odr-4 homolog OS=Homo sapiens GN=ODR4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49784 BP_3 7.00 0.51 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49786 BP_3 255.24 3.00 4395 189239183 XP_966847.2 1778 1.9e-195 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q69ZF3 1014 3.1e-108 Non-lysosomal glucosylceramidase OS=Mus musculus GN=Gba2 PE=1 SV=2 PF01232//PF04685 Mannitol dehydrogenase Rossmann domain//Protein of unknown function, DUF608 GO:0006687//GO:0005975//GO:0006807//GO:0055114//GO:0006665 glycosphingolipid metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process//oxidation-reduction process//sphingolipid metabolic process GO:0004348//GO:0016798//GO:0016491 glucosylceramidase activity//hydrolase activity, acting on glycosyl bonds//oxidoreductase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.49787 BP_3 770.00 12.02 3380 189239183 XP_966847.2 2940 0.0e+00 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q5M868 1550 1.7e-170 Non-lysosomal glucosylceramidase OS=Rattus norvegicus GN=Gba2 PE=2 SV=2 PF04685 Protein of unknown function, DUF608 GO:0006665//GO:0006680//GO:0006807//GO:0006687//GO:0005975 sphingolipid metabolic process//glucosylceramide catabolic process//nitrogen compound metabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process GO:0004348 glucosylceramidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.49789 BP_3 75.64 1.13 3530 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 6.9e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00072//PF00989//PF00233//PF05504//PF09771 Response regulator receiver domain//PAS fold//3'5'-cyclic nucleotide phosphodiesterase//Spore germination B3/ GerAC like, C-terminal//Transmembrane protein 188 GO:0006355//GO:0009847//GO:0006144//GO:0035307//GO:0000160//GO:0007165 regulation of transcription, DNA-templated//spore germination//purine nucleobase metabolic process//positive regulation of protein dephosphorylation//phosphorelay signal transduction system//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.49790 BP_3 92.08 3.31 1632 642911138 XP_971944.3 561 9.4e-55 PREDICTED: mitochondrial folate transporter/carrier isoform X2 [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q95J75 320 3.4e-28 Mitochondrial folate transporter/carrier OS=Macaca fascicularis GN=SLC25A32 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0764 Mitochondrial FAD carrier protein Cluster-8309.49792 BP_3 467.28 4.16 5703 752869980 XP_011252123.1 2489 9.0e-278 PREDICTED: von Willebrand factor A domain-containing protein 8 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q8CC88 2228 6.8e-249 von Willebrand factor A domain-containing protein 8 OS=Mus musculus GN=Vwa8 PE=2 SV=2 PF01443//PF10440//PF07724//PF00005//PF07726//PF03193//PF01637//PF00006//PF00493//PF00910//PF01695//PF07728//PF08477//PF01926//PF00158//PF00004//PF00421//PF02562 Viral (Superfamily 1) RNA helicase//Ubiquitin-binding WIYLD domain//AAA domain (Cdc48 subfamily)//ABC transporter//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//Archaeal ATPase//ATP synthase alpha/beta family, nucleotide-binding domain//MCM2/3/5 family//RNA helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Photosystem II protein//PhoH-like protein GO:0007264//GO:0009767//GO:0006479//GO:0019684//GO:0006554//GO:0006355//GO:0006260 small GTPase mediated signal transduction//photosynthetic electron transport chain//protein methylation//photosynthesis, light reaction//lysine catabolic process//regulation of transcription, DNA-templated//DNA replication GO:0003723//GO:0003677//GO:0018024//GO:0003724//GO:0005525//GO:0003924//GO:0008134//GO:0005524//GO:0016168//GO:0016887 RNA binding//DNA binding//histone-lysine N-methyltransferase activity//RNA helicase activity//GTP binding//GTPase activity//transcription factor binding//ATP binding//chlorophyll binding//ATPase activity GO:0005667//GO:0016020//GO:0009521 transcription factor complex//membrane//photosystem KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.49793 BP_3 1617.05 21.88 3854 478251380 ENN71846.1 1036 1.9e-109 hypothetical protein YQE_11464, partial [Dendroctonus ponderosae] -- -- -- -- -- K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 Q7ZXE9 429 1.9e-40 Testin OS=Xenopus laevis GN=tes PE=2 SV=1 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.49794 BP_3 169.25 3.22 2829 91079124 XP_975420.1 615 8.9e-61 PREDICTED: proteasome assembly chaperone 2 [Tribolium castaneum]>gi|270003633|gb|EFA00081.1| hypothetical protein TcasGA2_TC002896 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14735//PF13912//PF07776//PF13465//PF00096//PF07975 HAUS augmin-like complex subunit 4//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain GO:0006281//GO:0051225 DNA repair//spindle assembly GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0070652//GO:0005634 HAUS complex//nucleus -- -- Cluster-8309.49797 BP_3 353.21 2.43 7306 642911815 XP_008200755.1 6671 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 611 2.8e-61 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 PF01726 LexA DNA binding domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.498 BP_3 3.00 9.90 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49802 BP_3 4.00 2.48 366 642925814 XP_970128.3 236 1.0e-17 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12242//PF02737//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0006554//GO:0006552//GO:0055114//GO:0006631//GO:0006568//GO:0006574//GO:0006550//GO:0006633//GO:0018874//GO:0008152 lysine catabolic process//leucine catabolic process//oxidation-reduction process//fatty acid metabolic process//tryptophan metabolic process//valine catabolic process//isoleucine catabolic process//fatty acid biosynthetic process//benzoate metabolic process//metabolic process GO:0003857//GO:0016491//GO:0050662//GO:0003824 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.49803 BP_3 7.70 0.52 999 642915450 XP_008190622.1 1185 2.5e-127 PREDICTED: E3 ubiquitin-protein ligase MYCBP2 [Tribolium castaneum] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 Q7TPH6 828 2.6e-87 E3 ubiquitin-protein ligase MYCBP2 OS=Mus musculus GN=Mycbp2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.49805 BP_3 14.35 0.34 2330 642915450 XP_008190622.1 2617 5.3e-293 PREDICTED: E3 ubiquitin-protein ligase MYCBP2 [Tribolium castaneum] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 Q7TPH6 1678 1.7e-185 E3 ubiquitin-protein ligase MYCBP2 OS=Mus musculus GN=Mycbp2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.49807 BP_3 229.07 1.82 6363 270003917 EFA00365.1 7046 0.0e+00 hypothetical protein TcasGA2_TC003207 [Tribolium castaneum] 820837995 XM_012494632.1 48 6.01194e-13 PREDICTED: Apis florea E3 ubiquitin-protein ligase highwire-like (LOC100865814), transcript variant X9, mRNA K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 O75592 3448 0.0e+00 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3 PF13639//PF17123 Ring finger domain//RING-like zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.49808 BP_3 104.71 0.79 6655 270003917 EFA00365.1 6460 0.0e+00 hypothetical protein TcasGA2_TC003207 [Tribolium castaneum] 820837995 XM_012494632.1 48 6.28944e-13 PREDICTED: Apis florea E3 ubiquitin-protein ligase highwire-like (LOC100865814), transcript variant X9, mRNA K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 O75592 3448 0.0e+00 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3 PF17123//PF13639 RING-like zinc finger//Ring finger domain -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.49813 BP_3 34.94 0.48 3794 270008949 EFA05397.1 1203 7.9e-129 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97279 629 1.2e-63 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Mesocricetus auratus GN=ITIH2 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49815 BP_3 4.00 13.97 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49816 BP_3 9.92 0.47 1315 478252870 ENN73259.1 802 8.6e-83 hypothetical protein YQE_10155, partial [Dendroctonus ponderosae]>gi|546674747|gb|ERL86052.1| hypothetical protein D910_03466 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U145 311 3.0e-27 Transmembrane protein 64 OS=Mus musculus GN=Tmem64 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49817 BP_3 412.01 7.13 3077 751425405 AJF93908.1 2411 5.4e-269 FTZ F1 alpha [Leptinotarsa decemlineata] 642917896 XM_008193152.1 798 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1606 4.9e-177 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00288//PF00104//PF00105 GHMP kinases N terminal domain//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0003700//GO:0043565//GO:0008270 ATP binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.49818 BP_3 31.43 0.63 2691 751425407 AJF93909.1 2380 1.8e-265 FTZ F1 beta [Leptinotarsa decemlineata] 642917898 XM_008193153.1 541 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X3, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1628 1.2e-179 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00288//PF00104//PF00105 GHMP kinases N terminal domain//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0043565//GO:0008270//GO:0003700 ATP binding//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.49819 BP_3 33.90 0.96 1994 751425407 AJF93909.1 2183 9.5e-243 FTZ F1 beta [Leptinotarsa decemlineata] 751425406 KM091936.1 662 0 Leptinotarsa decemlineata FTZ F1 beta mRNA, complete cds K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1453 1.7e-159 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.49820 BP_3 11.47 0.75 1030 478259434 ENN79324.1 224 7.1e-16 hypothetical protein YQE_04233, partial [Dendroctonus ponderosae]>gi|546675175|gb|ERL86411.1| hypothetical protein D910_03818 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49822 BP_3 12.90 0.41 1807 642913378 XP_008195461.1 728 4.5e-74 PREDICTED: uncharacterized protein LOC657396 isoform X2 [Tribolium castaneum]>gi|270002028|gb|EEZ98475.1| hypothetical protein TcasGA2_TC000967 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.49823 BP_3 343.27 7.01 2653 189240781 XP_969579.2 1520 9.6e-166 PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum]>gi|642934322|ref|XP_008198600.1| PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum] 831504568 XM_012856442.1 55 3.19778e-17 PREDICTED: Fundulus heteroclitus inositol hexakisphosphate kinase 1 (ip6k1), mRNA K07756 IP6K, IHPK inositol-hexakisphosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07756 Q96PC2 434 3.4e-41 Inositol hexakisphosphate kinase 3 OS=Homo sapiens GN=IP6K3 PE=1 SV=2 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1620 Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex Cluster-8309.49825 BP_3 40.58 1.29 1811 345488645 XP_003425958.1 1012 5.3e-107 PREDICTED: T-cell activation inhibitor, mitochondrial isoform X1 [Nasonia vitripennis]>gi|645006689|ref|XP_008204888.1| PREDICTED: T-cell activation inhibitor, mitochondrial isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q66JZ4 365 2.3e-33 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49828 BP_3 18.69 1.62 848 642937828 XP_008200318.1 532 1.1e-51 PREDICTED: ethanolamine kinase 2 [Tribolium castaneum] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 Q9NVF9 395 3.6e-37 Ethanolamine kinase 2 OS=Homo sapiens GN=ETNK2 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4720 Ethanolamine kinase Cluster-8309.4983 BP_3 4.08 1.67 408 166998659 NP_001107798.1 252 1.6e-19 Snipper [Tribolium castaneum]>gi|156447793|gb|ABU63675.1| Snipper [Tribolium castaneum] -- -- -- -- -- K18417 ERI2 ERI1 exoribonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18417 A8K979 200 7.0e-15 ERI1 exoribonuclease 2 OS=Homo sapiens GN=ERI2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0542 Predicted exonuclease Cluster-8309.49830 BP_3 11.72 0.36 1861 91094379 XP_970941.1 1077 1.6e-114 PREDICTED: 39S ribosomal protein L4, mitochondrial [Tribolium castaneum]>gi|270014913|gb|EFA11361.1| hypothetical protein TcasGA2_TC011518 [Tribolium castaneum] -- -- -- -- -- K02926 RP-L4, MRPL4, rplD large subunit ribosomal protein L4 http://www.genome.jp/dbget-bin/www_bget?ko:K02926 Q32PI6 676 2.0e-69 39S ribosomal protein L4, mitochondrial OS=Bos taurus GN=MRPL4 PE=1 SV=1 PF01084//PF03497//PF00573 Ribosomal protein S18//Anthrax toxin LF subunit//Ribosomal protein L4/L1 family GO:0042254//GO:0006171//GO:0006412//GO:0009405 ribosome biogenesis//cAMP biosynthetic process//translation//pathogenesis GO:0003735//GO:0008294 structural constituent of ribosome//calcium- and calmodulin-responsive adenylate cyclase activity GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1624 Mitochondrial/chloroplast ribosomal protein L4 Cluster-8309.49831 BP_3 36.01 0.50 3765 189240011 XP_970535.2 1502 1.7e-163 PREDICTED: gamma-glutamyltranspeptidase 1 isoform X2 [Tribolium castaneum]>gi|642931571|ref|XP_008196639.1| PREDICTED: gamma-glutamyltranspeptidase 1 isoform X2 [Tribolium castaneum]>gi|270012173|gb|EFA08621.1| hypothetical protein TcasGA2_TC006284 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P20735 957 1.1e-101 Gamma-glutamyltranspeptidase 1 OS=Sus scrofa GN=GGT1 PE=2 SV=1 PF01019 Gamma-glutamyltranspeptidase GO:0006749//GO:0006693//GO:0019530//GO:0006691 glutathione metabolic process//prostaglandin metabolic process//taurine metabolic process//leukotriene metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.49833 BP_3 347.85 7.33 2578 478256352 ENN76542.1 1586 2.1e-173 hypothetical protein YQE_06993, partial [Dendroctonus ponderosae] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 Q60928 969 3.0e-103 Gamma-glutamyltranspeptidase 1 OS=Mus musculus GN=Ggt1 PE=1 SV=1 PF01019 Gamma-glutamyltranspeptidase GO:0019530//GO:0006691//GO:0006693//GO:0006749 taurine metabolic process//leukotriene metabolic process//prostaglandin metabolic process//glutathione metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.49837 BP_3 409.31 2.58 7953 86515334 NP_001034492.1 4335 0.0e+00 chitin synthase 2 [Tribolium castaneum]>gi|33867321|gb|AAQ55061.1| chitin synthase CHS2 [Tribolium castaneum]>gi|34148365|gb|AAQ62692.1| chitin synthase [Tribolium castaneum]>gi|270014271|gb|EFA10719.1| chitin synthase 2 [Tribolium castaneum] -- -- -- -- -- K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q9H3F6 928 5.2e-98 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens GN=KCTD10 PE=1 SV=1 PF03233//PF02214//PF02186//PF00651 Aphid transmission protein//BTB/POZ domain//TFIIE beta subunit core domain//BTB/POZ domain GO:0051260//GO:0006367//GO:0019089 protein homooligomerization//transcription initiation from RNA polymerase II promoter//transmission of virus GO:0016757//GO:0005515 transferase activity, transferring glycosyl groups//protein binding -- -- KOG2716 Polymerase delta-interacting protein PDIP1 and related proteins, contain BTB/POZ domain Cluster-8309.49838 BP_3 5.00 0.36 958 861594808 KMQ83108.1 376 1.6e-33 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00272 Cecropin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.4984 BP_3 15.46 1.10 967 642928748 XP_008199766.1 235 3.5e-17 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K03858 PIGH, GPI15 phosphatidylinositol glycan, class H http://www.genome.jp/dbget-bin/www_bget?ko:K03858 Q32L89 142 8.8e-08 Phosphatidylinositol N-acetylglucosaminyltransferase subunit H OS=Bos taurus GN=PIGH PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49840 BP_3 29.63 0.58 2756 270012474 EFA08922.1 1128 2.8e-120 hypothetical protein TcasGA2_TC006629 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 660 2.2e-67 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF05399//PF00498//PF12920 Ectropic viral integration site 2A protein (EVI2A)//FHA domain//TcdA/TcdB pore forming domain GO:0009405 pathogenesis GO:0005515 protein binding GO:0016021 integral component of membrane KOG3872 FOG: FHA domain Cluster-8309.49843 BP_3 16.05 0.45 2005 189234437 XP_966363.2 1336 1.6e-144 PREDICTED: BTB/POZ domain-containing protein 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08380 170 1.0e-10 Galectin-3-binding protein OS=Homo sapiens GN=LGALS3BP PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49846 BP_3 30.00 3.89 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49847 BP_3 364.05 4.58 4126 642931643 XP_008196669.1 765 5.3e-78 PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum]>gi|642931645|ref|XP_972490.2| PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum] -- -- -- -- -- K04701 CISH cytokine inducible SH2-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04701 O14508 228 4.0e-17 Suppressor of cytokine signaling 2 OS=Homo sapiens GN=SOCS2 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.49848 BP_3 345.91 2.54 6852 194880788 XP_001974544.1 2122 3.9e-235 GG21804 [Drosophila erecta]>gi|190657731|gb|EDV54944.1| GG21804 [Drosophila erecta] 572319027 XM_006625008.1 56 2.313e-17 PREDICTED: Apis dorsata E3 ubiquitin-protein ligase SMURF1-like (LOC102679083), mRNA K04678 SMURF E3 ubiquitin ligase SMURF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K04678 A9JRZ0 1867 5.9e-207 E3 ubiquitin-protein ligase SMURF2 OS=Danio rerio GN=smurf2 PE=2 SV=1 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.49852 BP_3 23.58 0.53 2452 308495432 XP_003109904.1 230 3.4e-16 hypothetical protein CRE_06611 [Caenorhabditis remanei]>gi|308244741|gb|EFO88693.1| hypothetical protein CRE_06611 [Caenorhabditis remanei] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49853 BP_3 61.18 0.69 4589 391657 BAA01703.1 2713 7.7e-304 unnamed protein product [Drosophila simulans] 123676641 AM473001.1 39 4.35905e-08 Vitis vinifera contig VV78X059590.2, whole genome shotgun sequence -- -- -- -- P04146 2709 9.2e-305 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF04273//PF00098//PF06072//PF00665//PF13683 Putative phosphatase (DUF442)//Zinc knuckle//Alphaherpesvirus tegument protein US9//Integrase core domain//Integrase core domain GO:0015074 DNA integration GO:0008270//GO:0016787//GO:0003676 zinc ion binding//hydrolase activity//nucleic acid binding GO:0019033 viral tegument -- -- Cluster-8309.49862 BP_3 156.50 6.78 1405 478257589 ENN77743.1 1232 1.3e-132 hypothetical protein YQE_05813, partial [Dendroctonus ponderosae]>gi|546677142|gb|ERL88039.1| hypothetical protein D910_05428 [Dendroctonus ponderosae] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 790 9.3e-83 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF03435//PF02325//PF13241//PF01408//PF00389//PF00899//PF02826//PF03446//PF00044//PF01118//PF02254 Saccharopine dehydrogenase NADP binding domain//YGGT family//Putative NAD(P)-binding//Oxidoreductase family, NAD-binding Rossmann fold//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Semialdehyde dehydrogenase, NAD binding domain//TrkA-N domain GO:0055114//GO:0006779//GO:0019521//GO:0006813//GO:0008152//GO:0019354//GO:0006098 oxidation-reduction process//porphyrin-containing compound biosynthetic process//D-gluconate metabolic process//potassium ion transport//metabolic process//siroheme biosynthetic process//pentose-phosphate shunt GO:0016620//GO:0008641//GO:0004616//GO:0051287//GO:0016616//GO:0016491//GO:0043115 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//small protein activating enzyme activity//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//precorrin-2 dehydrogenase activity GO:0016020 membrane KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.49863 BP_3 14.36 0.32 2454 642924106 XP_008194007.1 1803 1.4e-198 PREDICTED: serine/threonine-protein kinase mig-15 isoform X3 [Tribolium castaneum] 642924109 XM_008195787.1 569 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K08840 TNIK TRAF2 and NCK interacting kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08840 P83510 1409 2.7e-154 Traf2 and NCK-interacting protein kinase OS=Mus musculus GN=Tnik PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.49865 BP_3 285.32 4.99 3050 642922596 XP_970120.2 1845 2.3e-203 PREDICTED: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like [Tribolium castaneum] -- -- -- -- -- K05543 DUS2 tRNA-dihydrouridine synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05543 Q9NX74 1063 4.5e-114 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens GN=DUS2 PE=1 SV=1 PF10541//PF00977//PF01207 Nuclear envelope localisation domain//Histidine biosynthesis protein//Dihydrouridine synthase (Dus) GO:0055114//GO:0000105//GO:0008033 oxidation-reduction process//histidine biosynthetic process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity GO:0016021 integral component of membrane KOG2334 tRNA-dihydrouridine synthase Cluster-8309.49871 BP_3 24.55 0.43 3032 759056049 XP_011337263.1 1556 7.3e-170 PREDICTED: septin-2 isoform X2 [Cerapachys biroi] 749756922 XM_011142606.1 270 1.11031e-136 PREDICTED: Harpegnathos saltator septin-2 (LOC105184061), mRNA K16939 SEPT6_8_11 septin 6/8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K16939 P54359 1486 4.0e-163 Septin-2 OS=Drosophila melanogaster GN=Sep2 PE=2 SV=2 PF10186//PF00283//PF04111//PF01926//PF08477//PF00735//PF13897//PF00071//PF07926//PF00005//PF04799//PF03193 Vacuolar sorting 38 and autophagy-related subunit 14//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//Autophagy protein Apg6//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//Golgi-dynamics membrane-trafficking//Ras family//TPR/MLP1/MLP2-like protein//ABC transporter//fzo-like conserved region//Protein of unknown function, DUF258 GO:0015979//GO:0006914//GO:0006810//GO:0006606//GO:0008053//GO:0010508//GO:0007264 photosynthesis//autophagy//transport//protein import into nucleus//mitochondrial fusion//positive regulation of autophagy//small GTPase mediated signal transduction GO:0005524//GO:0003924//GO:0005525//GO:0016887 ATP binding//GTPase activity//GTP binding//ATPase activity GO:0016021//GO:0005741 integral component of membrane//mitochondrial outer membrane KOG3859 Septins (P-loop GTPases) Cluster-8309.49872 BP_3 148.60 1.81 4248 546685737 ERL95192.1 1349 1.0e-145 hypothetical protein D910_12460 [Dendroctonus ponderosae] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 1056 4.0e-113 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF03431//PF00202 RNA replicase, beta-chain//Aminotransferase class-III GO:0006144//GO:0019079 purine nucleobase metabolic process//viral genome replication GO:0008483//GO:0030170//GO:0003968 transaminase activity//pyridoxal phosphate binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.49873 BP_3 219.00 2.05 5433 546681355 ERL91465.1 2903 0.0e+00 hypothetical protein D910_08795 [Dendroctonus ponderosae] -- -- -- -- -- K13983 MOV10L1 putative helicase MOV10L1 http://www.genome.jp/dbget-bin/www_bget?ko:K13983 Q6J5K9 1597 9.5e-176 Probable RNA helicase armi OS=Drosophila melanogaster GN=armi PE=1 SV=4 PF00789//PF07545//PF04851//PF01443//PF02562 UBX domain//Vestigial/Tondu family//Type III restriction enzyme, res subunit//Viral (Superfamily 1) RNA helicase//PhoH-like protein GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0016787//GO:0003677//GO:0005515 ATP binding//hydrolase activity//DNA binding//protein binding GO:0005634 nucleus KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.49877 BP_3 448.43 17.12 1554 91081503 XP_974574.1 1439 1.4e-156 PREDICTED: actin-related protein 10 [Tribolium castaneum]>gi|270006151|gb|EFA02599.1| hypothetical protein TcasGA2_TC008318 [Tribolium castaneum] -- -- -- -- -- K16576 ACTR10, ARP11 actin-related protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16576 Q9QZB7 822 2.0e-86 Actin-related protein 10 OS=Mus musculus GN=Actr10 PE=1 SV=2 PF09446 VMA21-like domain GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.49882 BP_3 253.81 3.02 4338 478261444 ENN80814.1 1613 2.6e-176 hypothetical protein YQE_02771, partial [Dendroctonus ponderosae]>gi|546676398|gb|ERL87418.1| hypothetical protein D910_04813 [Dendroctonus ponderosae] 462382197 APGK01021748.1 104 3.03015e-44 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence K02433 gatA, QRSL1 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02433 Q17H91 1361 1.8e-148 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Aedes aegypti GN=gatA PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.49883 BP_3 13.75 0.35 2185 282400160 NP_001164203.1 2045 1.0e-226 cannonball [Tribolium castaneum]>gi|270008125|gb|EFA04573.1| cannonball [Tribolium castaneum] 379771659 JQ180221.1 187 1.09881e-90 Mylabris cichorii transcription initiation factor TFIID subunit 5 mRNA, partial cds K03130 TAF5 transcription initiation factor TFIID subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03130 Q15542 1223 8.9e-133 Transcription initiation factor TFIID subunit 5 OS=Homo sapiens GN=TAF5 PE=1 SV=3 PF00400//PF00039//PF04494 WD domain, G-beta repeat//Fibronectin type I domain//WD40 associated region in TFIID subunit, NTD2 domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005576//GO:0005634 extracellular region//nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.49884 BP_3 657.51 18.64 1992 332376669 AEE63474.1 618 2.8e-61 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B5XB27 336 5.8e-30 Kynurenine formamidase OS=Salmo salar GN=afmid PE=2 SV=1 PF00183//PF00326//PF07859 Hsp90 protein//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006950//GO:0008152//GO:0006457//GO:0006508 response to stress//metabolic process//protein folding//proteolysis GO:0005524//GO:0016787//GO:0051082//GO:0008236 ATP binding//hydrolase activity//unfolded protein binding//serine-type peptidase activity -- -- -- -- Cluster-8309.49885 BP_3 3753.76 78.96 2583 332376669 AEE63474.1 695 4.3e-70 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B5XB27 393 1.9e-36 Kynurenine formamidase OS=Salmo salar GN=afmid PE=2 SV=1 PF00183//PF00326//PF07859 Hsp90 protein//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0006950//GO:0008152//GO:0006457 proteolysis//response to stress//metabolic process//protein folding GO:0008236//GO:0051082//GO:0005524//GO:0016787 serine-type peptidase activity//unfolded protein binding//ATP binding//hydrolase activity -- -- -- -- Cluster-8309.49886 BP_3 345.00 26.81 912 642917470 XP_008191215.1 274 1.0e-21 PREDICTED: uncharacterized protein LOC103312421 [Tribolium castaneum]>gi|642917472|ref|XP_008191216.1| PREDICTED: uncharacterized protein LOC103312421 [Tribolium castaneum]>gi|270003451|gb|EEZ99898.1| hypothetical protein TcasGA2_TC002682 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49887 BP_3 34.22 1.40 1467 478249764 ENN70272.1 711 3.4e-72 hypothetical protein YQE_13055, partial [Dendroctonus ponderosae]>gi|546677444|gb|ERL88281.1| hypothetical protein D910_05668 [Dendroctonus ponderosae] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 O88801 240 5.8e-19 Homer protein homolog 2 OS=Rattus norvegicus GN=Homer2 PE=1 SV=1 PF04111//PF00170//PF06005//PF10473//PF07716//PF16326//PF04977//PF07352//PF06703//PF03938//PF07989//PF07926//PF04728//PF02183//PF00038//PF08702 Autophagy protein Apg6//bZIP transcription factor//Protein of unknown function (DUF904)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Basic region leucine zipper//ABC transporter C-terminal domain//Septum formation initiator//Bacteriophage Mu Gam like protein//Microsomal signal peptidase 25 kDa subunit (SPC25)//Outer membrane protein (OmpH-like)//Centrosomin N-terminal motif 1//TPR/MLP1/MLP2-like protein//Lipoprotein leucine-zipper//Homeobox associated leucine zipper//Intermediate filament protein//Fibrinogen alpha/beta chain family GO:0042262//GO:0030168//GO:0006606//GO:0006465//GO:0000917//GO:0043093//GO:0051258//GO:0006914//GO:0007165//GO:0007049//GO:0006355 DNA protection//platelet activation//protein import into nucleus//signal peptide processing//barrier septum assembly//FtsZ-dependent cytokinesis//protein polymerization//autophagy//signal transduction//cell cycle//regulation of transcription, DNA-templated GO:0030674//GO:0008134//GO:0045502//GO:0008233//GO:0003700//GO:0051082//GO:0005102//GO:0003677//GO:0003690//GO:0042803//GO:0005198//GO:0043565 protein binding, bridging//transcription factor binding//dynein binding//peptidase activity//transcription factor activity, sequence-specific DNA binding//unfolded protein binding//receptor binding//DNA binding//double-stranded DNA binding//protein homodimerization activity//structural molecule activity//sequence-specific DNA binding GO:0005667//GO:0030286//GO:0005882//GO:0005577//GO:0019867//GO:0005815//GO:0016021//GO:0005787//GO:0005737 transcription factor complex//dynein complex//intermediate filament//fibrinogen complex//outer membrane//microtubule organizing center//integral component of membrane//signal peptidase complex//cytoplasm -- -- Cluster-8309.49891 BP_3 77.18 5.02 1033 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16818 Protein SLM4 GO:0016237//GO:0007165 lysosomal microautophagy//signal transduction -- -- GO:0034448 EGO complex -- -- Cluster-8309.49892 BP_3 320.40 6.17 2793 270010128 EFA06576.1 1043 2.1e-110 hypothetical protein TcasGA2_TC009488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q968 711 2.7e-73 Protein N-terminal glutamine amidohydrolase OS=Anopheles gambiae GN=tun PE=3 SV=3 PF09764 N-terminal glutamine amidase GO:0006807 nitrogen compound metabolic process GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides -- -- KOG3261 Uncharacterized conserved protein Cluster-8309.49893 BP_3 310.69 8.22 2114 642929595 XP_008195898.1 1519 1.0e-165 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 992 5.3e-106 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 PF04721 PNGase C-terminal domain, mannose-binding module PAW GO:0006516 glycoprotein catabolic process -- -- GO:0005737 cytoplasm KOG0909 Peptide:N-glycanase Cluster-8309.49894 BP_3 274.09 2.60 5374 642929595 XP_008195898.1 1497 9.0e-163 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 986 6.7e-105 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 PF02532//PF04721//PF06736//PF08395 Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//PNGase C-terminal domain, mannose-binding module PAW//Protein of unknown function (DUF1211)//7tm Chemosensory receptor GO:0050909//GO:0006516//GO:0006813//GO:0015979 sensory perception of taste//glycoprotein catabolic process//potassium ion transport//photosynthesis GO:0005267 potassium channel activity GO:0009539//GO:0009523//GO:0005737//GO:0016020//GO:0016021 photosystem II reaction center//photosystem II//cytoplasm//membrane//integral component of membrane KOG0909 Peptide:N-glycanase Cluster-8309.49897 BP_3 45.83 0.42 5587 642929595 XP_008195898.1 1497 9.4e-163 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 986 6.9e-105 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 PF02532//PF04721//PF08395//PF06736 Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//PNGase C-terminal domain, mannose-binding module PAW//7tm Chemosensory receptor//Protein of unknown function (DUF1211) GO:0015979//GO:0006813//GO:0050909//GO:0006516 photosynthesis//potassium ion transport//sensory perception of taste//glycoprotein catabolic process GO:0005267 potassium channel activity GO:0016021//GO:0016020//GO:0009539//GO:0009523//GO:0005737 integral component of membrane//membrane//photosystem II reaction center//photosystem II//cytoplasm KOG0909 Peptide:N-glycanase Cluster-8309.49900 BP_3 68.00 3.81 1152 193878327 ACF25908.1 283 1.1e-22 crustin-2 [Eriocheir sinensis]>gi|239909562|gb|ACS32493.1| crustin III [Eriocheir sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49902 BP_3 36.94 0.47 4096 270014491 EFA10939.1 1976 2.0e-218 hypothetical protein TcasGA2_TC001770 [Tribolium castaneum] 751473836 XM_011193984.1 157 9.85784e-74 PREDICTED: Bactrocera cucurbitae endochitinase (LOC105218422), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 P36362 1683 7.7e-186 Endochitinase OS=Manduca sexta PE=2 SV=1 PF01607//PF00704//PF03427//PF01757 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18//Carbohydrate binding domain (family 19)//Acyltransferase family GO:0006030//GO:0006032//GO:0005975 chitin metabolic process//chitin catabolic process//carbohydrate metabolic process GO:0004553//GO:0008061//GO:0016747 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005576 extracellular region KOG2806 Chitinase Cluster-8309.49904 BP_3 6.53 0.31 1293 642938395 XP_971552.2 279 3.7e-22 PREDICTED: probable oligoribonuclease isoform X1 [Tribolium castaneum] -- -- -- -- -- K13288 orn, REX2, REXO2 oligoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K13288 Q9VCI0 232 4.3e-18 Probable oligoribonuclease OS=Drosophila melanogaster GN=CG10214 PE=1 SV=1 PF08395//PF02949 7tm Chemosensory receptor//7tm Odorant receptor GO:0007187//GO:0050909//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of taste//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3242 Oligoribonuclease (3'->5' exoribonuclease) Cluster-8309.49906 BP_3 19.08 0.90 1313 478260591 ENN80294.1 316 1.9e-26 hypothetical protein YQE_03287, partial [Dendroctonus ponderosae]>gi|546685277|gb|ERL94804.1| hypothetical protein D910_12078 [Dendroctonus ponderosae] -- -- -- -- -- K12176 COPS2, CSN2, TRIP15 COP9 signalosome complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12176 Q6IR75 292 4.8e-25 COP9 signalosome complex subunit 2 (Fragment) OS=Xenopus laevis GN=csn2 PE=2 SV=1 PF01399 PCI domain -- -- GO:0005515 protein binding -- -- KOG1464 COP9 signalosome, subunit CSN2 Cluster-8309.49907 BP_3 328.92 10.41 1814 801375161 XP_012063342.1 2126 3.5e-236 PREDICTED: COP9 signalosome complex subunit 2 [Atta cephalotes] 807038124 XM_004533924.2 381 0 PREDICTED: Ceratitis capitata COP9 signalosome complex subunit 2 (LOC101459187), mRNA K12176 COPS2, CSN2, TRIP15 COP9 signalosome complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12176 Q94899 2025 7.5e-226 COP9 signalosome complex subunit 2 OS=Drosophila melanogaster GN=alien PE=1 SV=2 PF13176//PF01399 Tetratricopeptide repeat//PCI domain -- -- GO:0005515 protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.49909 BP_3 114.51 0.71 8084 642918159 XP_008191391.1 1949 5.3e-215 PREDICTED: mucin-22 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 819 2.3e-85 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.49910 BP_3 6168.42 39.19 7879 642918163 XP_008191393.1 2589 3.1e-289 PREDICTED: mucin-22 isoform X3 [Tribolium castaneum] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 819 2.3e-85 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF01607 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region -- -- Cluster-8309.49912 BP_3 5.00 0.90 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49913 BP_3 18.00 0.49 2073 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49914 BP_3 286.00 8.04 2007 332374266 AEE62274.1 1745 5.9e-192 unknown [Dendroctonus ponderosae]>gi|546680061|gb|ERL90416.1| hypothetical protein D910_07765 [Dendroctonus ponderosae] -- -- -- -- -- K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 P17248 1497 1.4e-164 Tryptophan--tRNA ligase, cytoplasmic OS=Bos taurus GN=WARS PE=1 SV=3 PF00579 tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//ATP binding//nucleotide binding -- -- KOG2145 Cytoplasmic tryptophanyl-tRNA synthetase Cluster-8309.49915 BP_3 134.75 1.96 3601 189234531 XP_967948.2 893 6.6e-93 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 711 3.5e-73 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF13520//PF03522//PF00324 Amino acid permease//Solute carrier family 12//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0003333//GO:0006811 transmembrane transport//amino acid transport//transport//amino acid transmembrane transport//ion transport GO:0015171//GO:0005215 amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.49917 BP_3 31.18 0.66 2560 189233973 XP_975713.2 1356 9.6e-147 PREDICTED: serine/threonine-protein kinase 3 [Tribolium castaneum]>gi|270014571|gb|EFA11019.1| hypothetical protein TcasGA2_TC004606 [Tribolium castaneum] 156389256 XM_001634858.1 179 3.61344e-86 Nematostella vectensis predicted protein (NEMVEDRAFT_v1g241948) partial mRNA K04412 STK3, MST2 serine/threonine kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04412 Q7ZUQ3 1209 4.4e-131 Serine/threonine-protein kinase 3 OS=Danio rerio GN=stk3 PE=2 SV=1 PF11629//PF07714//PF07352//PF00069//PF16517 C terminal SARAH domain of Mst1//Protein tyrosine kinase//Bacteriophage Mu Gam like protein//Protein kinase domain//Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain GO:0016310//GO:0009069//GO:0006468//GO:0007165//GO:0042262 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//signal transduction//DNA protection GO:0005524//GO:0003690//GO:0004672//GO:0004674 ATP binding//double-stranded DNA binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0574 STE20-like serine/threonine kinase MST Cluster-8309.49918 BP_3 455.81 9.91 2508 189233973 XP_975713.2 2235 1.1e-248 PREDICTED: serine/threonine-protein kinase 3 [Tribolium castaneum]>gi|270014571|gb|EFA11019.1| hypothetical protein TcasGA2_TC004606 [Tribolium castaneum] 156389256 XM_001634858.1 179 3.53902e-86 Nematostella vectensis predicted protein (NEMVEDRAFT_v1g241948) partial mRNA K04412 STK3, MST2 serine/threonine kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04412 Q6IP06 1497 1.7e-164 Serine/threonine-protein kinase 3 OS=Xenopus laevis GN=stk3 PE=2 SV=1 PF16517//PF07714//PF11629//PF00069 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain//Protein tyrosine kinase//C terminal SARAH domain of Mst1//Protein kinase domain GO:0009069//GO:0006468//GO:0016310//GO:0007165 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//signal transduction GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0574 STE20-like serine/threonine kinase MST Cluster-8309.49921 BP_3 51.00 1.18 2371 759064429 XP_011341618.1 885 3.7e-92 PREDICTED: uncharacterized protein LOC105281809 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- B0BN95 137 8.2e-07 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.49923 BP_3 194.53 2.78 3670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49924 BP_3 86.68 1.29 3529 642922915 XP_008200450.1 3979 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X1 [Tribolium castaneum]>gi|270006550|gb|EFA02998.1| hypothetical protein TcasGA2_TC010420 [Tribolium castaneum] 642922916 XM_008202229.1 385 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5F499 2457 1.2e-275 Dynamin-like 120 kDa protein, mitochondrial OS=Gallus gallus GN=OPA1 PE=2 SV=1 PF01926//PF13304//PF06305//PF08477//PF00071//PF02421 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function (DUF1049)//Ras of Complex, Roc, domain of DAPkinase//Ras family//Ferrous iron transport protein B GO:0006184//GO:0007264//GO:0015684 obsolete GTP catabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0005524//GO:0003924//GO:0005525 ferrous iron transmembrane transporter activity//ATP binding//GTPase activity//GTP binding GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.49927 BP_3 56.45 0.40 7065 642920440 XP_008192351.1 1913 6.9e-211 PREDICTED: interference hedgehog-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 849 6.7e-89 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF13895//PF00041//PF16656//PF02480 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.49928 BP_3 99.99 0.82 6158 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.25979e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.2e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF01929//PF00787//PF00018//PF00620//PF14604 Ribosomal protein L14//PX domain//SH3 domain//RhoGAP domain//Variant SH3 domain GO:0006412//GO:0007165//GO:0042254//GO:0007154 translation//signal transduction//ribosome biogenesis//cell communication GO:0035091//GO:0005515//GO:0003735 phosphatidylinositol binding//protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.49930 BP_3 288.00 25.98 826 332374356 AEE62319.1 795 3.5e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08597 SENP8, NEDP1, DEN1 sentrin-specific protease 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08597 Q5FVJ8 358 6.8e-33 Sentrin-specific protease 8 OS=Rattus norvegicus GN=Senp8 PE=2 SV=1 PF02902 Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- KOG3246 Sentrin-specific cysteine protease (Ulp1 family) Cluster-8309.49932 BP_3 363.00 56.93 599 91088435 XP_967919.1 560 4.5e-55 PREDICTED: ragulator complex protein LAMTOR2 homolog [Tribolium castaneum]>gi|270011751|gb|EFA08199.1| hypothetical protein TcasGA2_TC005826 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V8I2 479 4.6e-47 Ragulator complex protein LAMTOR2 homolog OS=Drosophila melanogaster GN=CG5189 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4107 MP1 adaptor interacting protein P14 Cluster-8309.49934 BP_3 455.72 2.10 10743 642926389 XP_008194905.1 4856 0.0e+00 PREDICTED: citron Rho-interacting kinase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14578 2078 3.2e-231 Citron Rho-interacting kinase OS=Homo sapiens GN=CIT PE=1 SV=2 PF07714//PF00069//PF15367//PF00827//PF00130//PF13851//PF00433//PF01326//PF00391//PF09377 Protein tyrosine kinase//Protein kinase domain//Calcium-binding and spermatid-specific protein 1//Ribosomal L15//Phorbol esters/diacylglycerol binding domain (C1 domain)//Growth-arrest specific micro-tubule binding//Protein kinase C terminal domain//Pyruvate phosphate dikinase, PEP/pyruvate binding domain//PEP-utilising enzyme, mobile domain//SBDS protein C-terminal domain GO:0006468//GO:0009069//GO:0035556//GO:0042254//GO:0007283//GO:0048870//GO:0016310//GO:0006412 protein phosphorylation//serine family amino acid metabolic process//intracellular signal transduction//ribosome biogenesis//spermatogenesis//cell motility//phosphorylation//translation GO:0005524//GO:0004674//GO:0003735//GO:0016772//GO:0016301//GO:0004672//GO:0005509 ATP binding//protein serine/threonine kinase activity//structural constituent of ribosome//transferase activity, transferring phosphorus-containing groups//kinase activity//protein kinase activity//calcium ion binding GO:0031514//GO:0005840 motile cilium//ribosome KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.49938 BP_3 98.45 0.64 7656 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 8.0e-261 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF01344//PF00651//PF07646 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.49939 BP_3 755.86 4.16 9059 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 9.4e-261 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF07646//PF00651//PF01667//PF01344//PF00856 Kelch motif//BTB/POZ domain//Ribosomal protein S27//Kelch motif//SET domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840//GO:0005622 ribosome//intracellular KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.49945 BP_3 469.14 9.21 2748 642930650 XP_008199210.1 1816 4.7e-200 PREDICTED: ubiquitin carboxyl-terminal hydrolase 30 [Tribolium castaneum] -- -- -- -- -- K11851 USP30 ubiquitin carboxyl-terminal hydrolase 30 http://www.genome.jp/dbget-bin/www_bget?ko:K11851 Q9W462 475 6.1e-46 Ubiquitin carboxyl-terminal hydrolase 30 homolog OS=Drosophila melanogaster GN=CG3016 PE=2 SV=1 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0036459//GO:0032183//GO:0070140 ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity -- -- KOG1867 Ubiquitin-specific protease Cluster-8309.49950 BP_3 8.44 0.81 795 645004771 XP_008210751.1 420 1.0e-38 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100116128 [Nasonia vitripennis] 194893319 XM_001977817.1 74 2.54893e-28 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- -- -- -- -- PF05818 Enterobacterial TraT complement resistance protein GO:0046999 regulation of conjugation -- -- GO:0019867 outer membrane -- -- Cluster-8309.49952 BP_3 30.66 0.37 4237 91086089 XP_967008.1 1099 1.0e-116 PREDICTED: XK-related protein 7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5GH59 276 1.1e-22 XK-related protein 4 OS=Rattus norvegicus GN=Xkr4 PE=2 SV=1 PF09815 XK-related protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49953 BP_3 24.35 0.34 3776 546676381 ERL87403.1 680 3.5e-68 hypothetical protein D910_04798 [Dendroctonus ponderosae] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 391 4.6e-36 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF08122//PF01212//PF01053 NADH-ubiquinone oxidoreductase B12 subunit family//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0006520//GO:0022900 cellular amino acid metabolic process//electron transport chain GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding GO:0005747//GO:0005739 mitochondrial respiratory chain complex I//mitochondrion KOG1368 Threonine aldolase Cluster-8309.49956 BP_3 281.16 3.77 3883 642914519 XP_008201711.1 1016 3.9e-107 PREDICTED: post-GPI attachment to proteins factor 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWK6 648 7.5e-66 Post-GPI attachment to proteins factor 2-like OS=Drosophila melanogaster GN=CG7990 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG3979 FGF receptor activating protein 1 Cluster-8309.49957 BP_3 210.03 5.27 2214 642929686 XP_008195936.1 615 7.0e-61 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49960 BP_3 277.90 2.47 5705 91080703 XP_975295.1 987 1.3e-103 PREDICTED: uncharacterized protein LOC664189 [Tribolium castaneum]>gi|270005858|gb|EFA02306.1| hypothetical protein TcasGA2_TC007972 [Tribolium castaneum] 462358939 APGK01029925.1 99 2.40317e-41 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- Q8BJ05 260 1.1e-20 Zinc finger CCCH domain-containing protein 14 OS=Mus musculus GN=Zc3h14 PE=1 SV=1 PF01480//PF05830//PF03595 PWI domain//Nodulation protein Z (NodZ)//Voltage-dependent anion channel GO:0006397//GO:0009312//GO:0055085//GO:0009877 mRNA processing//oligosaccharide biosynthetic process//transmembrane transport//nodulation GO:0016758 transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane KOG3702 Nuclear polyadenylated RNA binding protein Cluster-8309.49961 BP_3 20.29 0.59 1957 270003490 EEZ99937.1 821 8.0e-85 hypothetical protein TcasGA2_TC002733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DM3 474 5.7e-46 Uncharacterized protein C18orf8 OS=Homo sapiens GN=C18orf8 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2377 Uncharacterized conserved protein Cluster-8309.49965 BP_3 42.43 1.26 1910 478250804 ENN71296.1 674 8.7e-68 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10976 ERO1LB ERO1-like protein beta http://www.genome.jp/dbget-bin/www_bget?ko:K10976 Q9V3A6 487 1.7e-47 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0003756//GO:0016671 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.49971 BP_3 394.00 9.16 2366 642913809 XP_008201168.1 397 1.4e-35 PREDICTED: putative WEB family protein At1g65010, chloroplastic [Tribolium castaneum]>gi|270001664|gb|EEZ98111.1| hypothetical protein TcasGA2_TC000528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9Q6 173 5.5e-11 FK506-binding protein 15 OS=Mus musculus GN=Fkbp15 PE=1 SV=2 PF10473//PF09177//PF04111//PF08650 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//Autophagy protein Apg6//DASH complex subunit Dad4 GO:0008608//GO:0048193//GO:0006914 attachment of spindle microtubules to kinetochore//Golgi vesicle transport//autophagy GO:0042803//GO:0008134//GO:0045502 protein homodimerization activity//transcription factor binding//dynein binding GO:0016020//GO:0042729//GO:0030286//GO:0072686//GO:0005667 membrane//DASH complex//dynein complex//mitotic spindle//transcription factor complex -- -- Cluster-8309.49973 BP_3 37.58 0.41 4694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49977 BP_3 51.15 0.61 4355 642938610 XP_008199864.1 3197 0.0e+00 PREDICTED: protein trachealess [Tribolium castaneum] 820805579 KP147944.1 572 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1108 3.9e-119 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF00989//PF08447//PF04551//PF00010 PAS fold//PAS fold//GcpE protein//Helix-loop-helix DNA-binding domain GO:0006355//GO:0055114//GO:0016114 regulation of transcription, DNA-templated//oxidation-reduction process//terpenoid biosynthetic process GO:0046983//GO:0046429//GO:0005515 protein dimerization activity//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//protein binding -- -- -- -- Cluster-8309.49978 BP_3 56.99 0.96 3144 688549490 XP_009298860.1 580 1.1e-56 PREDICTED: gastrula zinc finger protein XlCGF57.1-like [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9EQB9 575 1.8e-57 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF04810//PF00412//PF13912//PF14972//PF00096//PF13465//PF09174 Sec23/Sec24 zinc finger//LIM domain//C2H2-type zinc finger//Mitochondrial morphogenesis regulator//Zinc finger, C2H2 type//Zinc-finger double domain//Maf1 regulator GO:0006886//GO:0016480//GO:0006888//GO:0007005 intracellular protein transport//negative regulation of transcription from RNA polymerase III promoter//ER to Golgi vesicle-mediated transport//mitochondrion organization GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0030127//GO:0031305 COPII vesicle coat//integral component of mitochondrial inner membrane -- -- Cluster-8309.49979 BP_3 19.00 1.53 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49980 BP_3 5.00 0.52 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49981 BP_3 76.49 1.52 2724 688549490 XP_009298860.1 543 1.9e-52 PREDICTED: gastrula zinc finger protein XlCGF57.1-like [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9EQB9 532 1.5e-52 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF05191//PF13912//PF00412//PF09174//PF00096//PF13465 Adenylate kinase, active site lid//C2H2-type zinc finger//LIM domain//Maf1 regulator//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006144//GO:0046034//GO:0016480 purine nucleobase metabolic process//ATP metabolic process//negative regulation of transcription from RNA polymerase III promoter GO:0008270//GO:0046872//GO:0004017 zinc ion binding//metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.49982 BP_3 595.51 12.93 2511 642936826 XP_008197806.1 2492 1.8e-278 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1 [Tribolium castaneum]>gi|270000937|gb|EEZ97384.1| hypothetical protein TcasGA2_TC011210 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 1889 6.1e-210 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00628//PF00130//PF00622 PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//SPRY domain GO:0035556 intracellular signal transduction GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.49983 BP_3 2.32 0.32 643 189241520 XP_968500.2 501 3.3e-48 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 335 2.4e-30 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49987 BP_3 95.23 0.67 7154 91077932 XP_974190.1 2678 1.4e-299 PREDICTED: conserved oligomeric Golgi complex subunit 7 [Tribolium castaneum] 820862785 XM_003697932.2 121 1.77708e-53 PREDICTED: Apis florea U4/U6 small nuclear ribonucleoprotein Prp4 (LOC100870360), mRNA K12662 PRPF4, PRP4 U4/U6 small nuclear ribonucleoprotein PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K12662 Q3MHE2 1614 1.3e-177 U4/U6 small nuclear ribonucleoprotein Prp4 OS=Bos taurus GN=PRPF4 PE=2 SV=1 PF10191//PF10392//PF00400//PF02468 Golgi complex component 7 (COG7)//Golgi transport complex subunit 5//WD domain, G-beta repeat//Photosystem II reaction centre N protein (psbN) GO:0006891//GO:0015979//GO:0006886 intra-Golgi vesicle-mediated transport//photosynthesis//intracellular protein transport GO:0005515 protein binding GO:0017119//GO:0016020//GO:0009523//GO:0009539 Golgi transport complex//membrane//photosystem II//photosystem II reaction center KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats) Cluster-8309.49991 BP_3 26.01 4.08 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49994 BP_3 1448.00 46.43 1795 237681128 NP_001153709.1 2550 2.4e-285 eukaryotic initiation factor 3 p66 subunit [Tribolium castaneum] 766940977 XM_011504807.1 209 5.29985e-103 PREDICTED: Ceratosolen solmsi marchali eukaryotic translation initiation factor 3 subunit D (LOC105366385), mRNA K03251 EIF3D translation initiation factor 3 subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K03251 Q7QBW3 2128 8.4e-238 Eukaryotic translation initiation factor 3 subunit D OS=Anopheles gambiae GN=eIF3-S7 PE=3 SV=3 PF10505//PF05091//PF01788 NMDA receptor-regulated gene protein 2 C-terminus//Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)//PsbJ GO:0015979//GO:0006446 photosynthesis//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0008023//GO:0005840//GO:0016020//GO:0005852//GO:0009539//GO:0005737//GO:0009523 transcription elongation factor complex//ribosome//membrane//eukaryotic translation initiation factor 3 complex//photosystem II reaction center//cytoplasm//photosystem II KOG2479 Translation initiation factor 3, subunit d (eIF-3d) Cluster-8309.49995 BP_3 376.93 7.53 2703 642929864 XP_008196005.1 2407 1.4e-268 PREDICTED: cactin isoform X2 [Tribolium castaneum] 696122558 KF828752.1 126 1.10684e-56 Rhipicephalus microplus Cactin mRNA, partial cds -- -- -- -- Q9VR99 1610 1.5e-177 Cactin OS=Drosophila melanogaster GN=cactin PE=1 SV=3 PF09732 Cactus-binding C-terminus of cactin protein -- -- GO:0005515 protein binding -- -- KOG2370 Cactin Cluster-8309.49996 BP_3 613.15 5.04 6160 189240093 XP_972388.2 1454 1.0e-157 PREDICTED: myosin heavy chain, clone 203 isoform X1 [Tribolium castaneum]>gi|270012237|gb|EFA08685.1| hypothetical protein TcasGA2_TC006355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05929//PF04048//PF01465//PF04508//PF10186 Phage capsid scaffolding protein (GPO) serine peptidase//Sec8 exocyst complex component specific domain//GRIP domain//Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0019069//GO:0010508//GO:0000042//GO:0015031//GO:0006904//GO:0016032 viral capsid assembly//positive regulation of autophagy//protein targeting to Golgi//protein transport//vesicle docking involved in exocytosis//viral process GO:0005515 protein binding GO:0000145 exocyst -- -- Cluster-8309.49998 BP_3 358.22 16.47 1340 642933482 XP_008197436.1 1172 1.1e-125 PREDICTED: luc7-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95232 670 7.3e-69 Luc7-like protein 3 OS=Homo sapiens GN=LUC7L3 PE=1 SV=2 PF08027//PF03194//PF05887 Albumin I chain b//LUC7 N_terminus//Procyclic acidic repetitive protein (PARP) GO:0009405//GO:0006376 pathogenesis//mRNA splice site selection GO:0045735//GO:0003729 nutrient reservoir activity//mRNA binding GO:0005685//GO:0016020 U1 snRNP//membrane KOG0796 Spliceosome subunit Cluster-8309.49999 BP_3 385.78 11.41 1921 642933482 XP_008197436.1 1172 1.6e-125 PREDICTED: luc7-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95232 670 1.0e-68 Luc7-like protein 3 OS=Homo sapiens GN=LUC7L3 PE=1 SV=2 PF05887//PF03194//PF08027 Procyclic acidic repetitive protein (PARP)//LUC7 N_terminus//Albumin I chain b GO:0009405//GO:0006376 pathogenesis//mRNA splice site selection GO:0003729//GO:0045735 mRNA binding//nutrient reservoir activity GO:0005685//GO:0016020 U1 snRNP//membrane KOG0796 Spliceosome subunit Cluster-8309.5 BP_3 14.00 0.82 1114 -- -- -- -- -- 462329931 APGK01040186.1 53 1.707e-16 Dendroctonus ponderosae Seq01040196, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50000 BP_3 363.00 7.56 2606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50002 BP_3 40.66 1.52 1580 815793737 XP_012217495.1 220 3.2e-15 PREDICTED: mucin-17-like [Linepithema humile] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50003 BP_3 151.00 7.56 1254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50005 BP_3 59.86 1.51 2201 642912820 XP_008201266.1 477 7.0e-45 PREDICTED: DNA damage-regulated autophagy modulator protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC48 292 8.1e-25 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4320 Uncharacterized conserved protein Cluster-8309.50006 BP_3 46.28 0.96 2620 270001923 EEZ98370.1 376 4.3e-33 hypothetical protein TcasGA2_TC000828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC48 223 9.7e-17 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 PF01825 GPCR proteolysis site, GPS, motif -- -- -- -- GO:0016020 membrane KOG4320 Uncharacterized conserved protein Cluster-8309.50008 BP_3 53.37 0.44 6094 642935103 XP_008197888.1 1698 5.1e-186 PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935105|ref|XP_008197889.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935107|ref|XP_008197890.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935109|ref|XP_008197891.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935111|ref|XP_008197892.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01226//PF02623//PF09907//PF07535 Formate/nitrite transporter//FliW protein//HigB_toxin, RelE-like toxic component of a toxin-antitoxin system//DBF zinc finger GO:0006810//GO:0044780 transport//bacterial-type flagellum assembly GO:0005215//GO:0003676//GO:0016788//GO:0008270 transporter activity//nucleic acid binding//hydrolase activity, acting on ester bonds//zinc ion binding GO:0016020 membrane -- -- Cluster-8309.50009 BP_3 10.24 0.45 1387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50010 BP_3 18.58 0.96 1228 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50012 BP_3 149.73 1.85 4188 478250013 ENN70519.1 1223 4.2e-131 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 192 6.1e-13 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF02388//PF01280 FemAB family//Ribosomal protein L19e GO:0009252//GO:0006412//GO:0042254 peptidoglycan biosynthetic process//translation//ribosome biogenesis GO:0016755//GO:0003735 transferase activity, transferring amino-acyl groups//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.50013 BP_3 800.33 3.74 10601 270005280 EFA01728.1 8299 0.0e+00 hypothetical protein TcasGA2_TC007308 [Tribolium castaneum] 642920256 XM_008194048.1 93 9.69062e-38 PREDICTED: Tribolium castaneum pecanex-like protein 1 (LOC664487), transcript variant X2, mRNA -- -- -- -- Q96RV3 3295 0.0e+00 Pecanex-like protein 1 OS=Homo sapiens GN=PCNX PE=1 SV=2 PF11095//PF05041//PF06753 Gem-associated protein 7 (Gemin7)//Pecanex protein (C-terminus)//Bradykinin GO:0006950//GO:0007165 response to stress//signal transduction GO:0005179 hormone activity GO:0032797//GO:0016021//GO:0005576 SMN complex//integral component of membrane//extracellular region KOG3604 Pecanex Cluster-8309.50016 BP_3 51.04 0.35 7304 642911196 XP_008199563.1 2674 4.1e-299 PREDICTED: solute carrier family 12 member 4 isoform X1 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.38069e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 1974 2.5e-219 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF13520//PF02450//PF03522//PF00324//PF05038 Amino acid permease//Lecithin:cholesterol acyltransferase//Solute carrier family 12//Amino acid permease//Cytochrome Cytochrome b558 alpha-subunit GO:0006811//GO:0003333//GO:0042967//GO:0006810//GO:0006629//GO:0006865//GO:0055085 ion transport//amino acid transmembrane transport//acyl-carrier-protein biosynthetic process//transport//lipid metabolic process//amino acid transport//transmembrane transport GO:0020037//GO:0005215//GO:0008374//GO:0015171 heme binding//transporter activity//O-acyltransferase activity//amino acid transmembrane transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.50019 BP_3 12.00 21.15 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50020 BP_3 208.00 8.19 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50024 BP_3 43.63 1.24 1987 642920075 XP_008192196.1 1290 3.4e-139 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 793 5.9e-83 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03453 MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.50025 BP_3 365.56 6.23 3118 642920075 XP_008192196.1 1129 2.5e-120 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 742 7.6e-77 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03454//PF03453 MoeA C-terminal region (domain IV)//MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.50026 BP_3 2.00 0.38 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50027 BP_3 34.70 0.88 2182 270006380 EFA02828.1 295 8.8e-24 insulin-like growth factor receptor [Tribolium castaneum]>gi|570932717|gb|AHF20215.1| insulin like receptor 2 [Tribolium castaneum] -- -- -- -- -- K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q9WTL4 239 1.1e-18 Insulin receptor-related protein OS=Mus musculus GN=Insrr PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50028 BP_3 229.31 1.08 10537 270006380 EFA02828.1 2538 3.4e-283 insulin-like growth factor receptor [Tribolium castaneum]>gi|570932717|gb|AHF20215.1| insulin like receptor 2 [Tribolium castaneum] 471364329 XM_004372657.1 83 3.48885e-32 PREDICTED: Trichechus manatus latirostris insulin-like growth factor 1 receptor (LOC101355333), mRNA K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q60751 1871 3.1e-207 Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 PF16656//PF08727//PF00757//PF00909//PF00041//PF00069//PF07714 Purple acid Phosphatase, N-terminal domain//Poliovirus 3A protein like//Furin-like cysteine rich region//Ammonium Transporter Family//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase GO:0015696//GO:0006144//GO:0006508//GO:0006771//GO:0007169//GO:0019497//GO:0006468 ammonium transport//purine nucleobase metabolic process//proteolysis//riboflavin metabolic process//transmembrane receptor protein tyrosine kinase signaling pathway//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0005515//GO:0003968//GO:0017111//GO:0004714//GO:0004672//GO:0046872//GO:0004197//GO:0005524//GO:0008519//GO:0003993 protein binding//RNA-directed RNA polymerase activity//nucleoside-triphosphatase activity//transmembrane receptor protein tyrosine kinase activity//protein kinase activity//metal ion binding//cysteine-type endopeptidase activity//ATP binding//ammonium transmembrane transporter activity//acid phosphatase activity GO:0016020//GO:0031379 membrane//RNA-directed RNA polymerase complex KOG3796 Ammonium transporter RHBG Cluster-8309.50034 BP_3 82.22 1.43 3066 478257160 ENN77323.1 1838 1.5e-202 hypothetical protein YQE_06149, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IVI9 341 2.4e-30 Nostrin OS=Homo sapiens GN=NOSTRIN PE=1 SV=2 PF02185 Hr1 repeat GO:0007165 signal transduction -- -- -- -- KOG3158 HSP90 co-chaperone p23 Cluster-8309.50035 BP_3 4.24 0.41 786 546681430 ERL91527.1 377 9.8e-34 hypothetical protein D910_08857 [Dendroctonus ponderosae] -- -- -- -- -- K15730 PTGES3 cytosolic prostaglandin-E synthase http://www.genome.jp/dbget-bin/www_bget?ko:K15730 Q9VH95 159 7.7e-10 Uncharacterized protein CG16817 OS=Drosophila melanogaster GN=CG16817 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50039 BP_3 18.60 1.00 1188 270008834 EFA05282.1 830 4.4e-86 hypothetical protein TcasGA2_TC015439 [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02599 388 3.2e-36 Calmodulin OS=Dictyostelium discoideum GN=calA PE=1 SV=3 PF13499//PF10591//PF13833//PF00036//PF13405//PF12763//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//Cytoskeletal-regulatory complex EF hand//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.5004 BP_3 99.87 2.62 2126 91091050 XP_975260.1 1821 9.6e-201 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270014061|gb|EFA10509.1| hypothetical protein TcasGA2_TC012760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17NV8 583 1.4e-58 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF07690//PF03137//PF00083 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Sugar (and other) transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.50040 BP_3 10.29 0.36 1672 642921818 XP_008199331.1 193 4.5e-12 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.50044 BP_3 73.70 0.88 4322 642925718 XP_973763.2 936 8.2e-98 PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4GAP7 488 3.0e-47 Facilitated trehalose transporter Tret1 OS=Drosophila persimilis GN=Tret1 PE=3 SV=2 PF00083//PF10483//PF07690//PF05493 Sugar (and other) transporter//Elongator subunit Iki1//Major Facilitator Superfamily//ATP synthase subunit H GO:0015992//GO:0015991//GO:0055085 proton transport//ATP hydrolysis coupled proton transport//transmembrane transport GO:0015078//GO:0022857 hydrogen ion transmembrane transporter activity//transmembrane transporter activity GO:0033588//GO:0033179//GO:0016021 Elongator holoenzyme complex//proton-transporting V-type ATPase, V0 domain//integral component of membrane -- -- Cluster-8309.50045 BP_3 80.33 3.77 1319 642918845 XP_008191611.1 681 9.3e-69 PREDICTED: phosphoglycolate phosphatase 2-like [Tribolium castaneum]>gi|270005689|gb|EFA02137.1| hypothetical protein TcasGA2_TC007787 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 314 1.4e-27 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 PF02310 B12 binding domain -- -- GO:0046872//GO:0031419 metal ion binding//cobalamin binding -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.50046 BP_3 16.00 1.10 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.50048 BP_3 369.52 3.82 4957 642910200 XP_008198377.1 2478 1.5e-276 PREDICTED: N-alpha-acetyltransferase 35, NatC auxiliary subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZHV2 1716 1.4e-189 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Gallus gallus GN=NAA35 PE=2 SV=1 PF08336//PF08287//PF01442//PF02050 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Spc19//Apolipoprotein A1/A4/E domain//Flagellar FliJ protein GO:0042157//GO:0006935//GO:0006869//GO:0071973//GO:0006560//GO:0008608//GO:0055114//GO:0006525//GO:0018401 lipoprotein metabolic process//chemotaxis//lipid transport//bacterial-type flagellum-dependent cell motility//proline metabolic process//attachment of spindle microtubules to kinetochore//oxidation-reduction process//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0003774//GO:0008289//GO:0004656//GO:0016702 motor activity//lipid binding//procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005576//GO:0016020//GO:0005783//GO:0042729//GO:0009288//GO:0005876 extracellular region//membrane//endoplasmic reticulum//DASH complex//bacterial-type flagellum//spindle microtubule KOG2343 Glucose-repressible protein and related proteins Cluster-8309.50049 BP_3 76.69 0.92 4314 189233937 XP_973896.2 1951 1.6e-215 PREDICTED: conserved oligomeric Golgi complex subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T322 797 4.4e-83 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Danio rerio GN=naa35 PE=2 SV=1 PF02050//PF08336//PF01442//PF08287 Flagellar FliJ protein//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Apolipoprotein A1/A4/E domain//Spc19 GO:0006935//GO:0042157//GO:0006869//GO:0071973//GO:0006560//GO:0006525//GO:0018401//GO:0008608//GO:0055114 chemotaxis//lipoprotein metabolic process//lipid transport//bacterial-type flagellum-dependent cell motility//proline metabolic process//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//attachment of spindle microtubules to kinetochore//oxidation-reduction process GO:0004656//GO:0008289//GO:0003774//GO:0016702 procollagen-proline 4-dioxygenase activity//lipid binding//motor activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005783//GO:0005576//GO:0016020//GO:0009288//GO:0042729//GO:0005876 endoplasmic reticulum//extracellular region//membrane//bacterial-type flagellum//DASH complex//spindle microtubule KOG2343 Glucose-repressible protein and related proteins Cluster-8309.50051 BP_3 202.85 2.18 4781 642923482 XP_008193528.1 1562 2.3e-170 PREDICTED: hyccin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BYI3 417 5.7e-39 Hyccin OS=Homo sapiens GN=FAM126A PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.50052 BP_3 111.36 3.17 1985 642923487 XP_008193531.1 316 2.9e-26 PREDICTED: RNA binding protein fox-1 homolog 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50053 BP_3 18.21 5.06 465 546677542 ERL88361.1 236 1.3e-17 hypothetical protein D910_05748, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01426 BAH domain -- -- GO:0003682 chromatin binding GO:0000785 chromatin -- -- Cluster-8309.50054 BP_3 12.00 0.38 1822 478249914 ENN70421.1 260 8.4e-20 hypothetical protein YQE_12926, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C4S8 149 2.6e-08 DENN domain-containing protein 2A OS=Mus musculus GN=Dennd2a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50056 BP_3 349.79 11.22 1794 478249914 ENN70421.1 958 9.6e-101 hypothetical protein YQE_12926, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P78524 186 1.3e-12 Suppression of tumorigenicity 5 protein OS=Homo sapiens GN=ST5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50057 BP_3 19.51 0.50 2177 478252879 ENN73268.1 277 1.1e-21 hypothetical protein YQE_10163, partial [Dendroctonus ponderosae]>gi|546673885|gb|ERL85407.1| hypothetical protein D910_02827, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50058 BP_3 7.17 0.66 815 91092902 XP_971056.1 495 2.1e-47 PREDICTED: N-acetyltransferase 9-like protein [Tribolium castaneum]>gi|270003097|gb|EEZ99544.1| hypothetical protein TcasGA2_TC000126 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7SLC8 273 4.8e-23 N-acetyltransferase 9-like protein OS=Nematostella vectensis GN=nat9 PE=3 SV=1 PF13302 Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG4135 Predicted phosphoglucosamine acetyltransferase Cluster-8309.50059 BP_3 297.23 18.87 1051 642933799 XP_008197333.1 1000 7.5e-106 PREDICTED: PIH1 domain-containing protein 1 [Tribolium castaneum]>gi|270013593|gb|EFA10041.1| hypothetical protein TcasGA2_TC012213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZWY2 469 1.2e-45 PIH1 domain-containing protein 1 OS=Xenopus laevis GN=pih1d1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50063 BP_3 175.14 12.69 957 478254555 ENN74798.1 694 2.1e-70 hypothetical protein YQE_08571, partial [Dendroctonus ponderosae]>gi|546681658|gb|ERL91709.1| hypothetical protein D910_09036 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q92626 207 2.5e-15 Peroxidasin homolog OS=Homo sapiens GN=PXDN PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50064 BP_3 34.13 0.83 2279 91091974 XP_968950.1 1069 1.6e-113 PREDICTED: protein prenyltransferase alpha subunit repeat-containing protein 1-B [Tribolium castaneum]>gi|270001151|gb|EEZ97598.1| hypothetical protein TcasGA2_TC011467 [Tribolium castaneum] -- -- -- -- -- K14137 PTAR1 protein prenyltransferase alpha subunit repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14137 A1L3L1 385 1.4e-35 Protein prenyltransferase alpha subunit repeat-containing protein 1-B (Fragment) OS=Xenopus laevis GN=ptar1-b PE=2 SV=1 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- -- -- Cluster-8309.50066 BP_3 386.00 9.27 2299 91094257 XP_969374.1 1055 6.9e-112 PREDICTED: BUD13 homolog [Tribolium castaneum]>gi|270016259|gb|EFA12705.1| hypothetical protein TcasGA2_TC002339 [Tribolium castaneum] -- -- -- -- -- K13106 BUD13, CWC26 pre-mRNA-splicing factor CWC26 http://www.genome.jp/dbget-bin/www_bget?ko:K13106 P30640 569 6.4e-57 BUD13 homolog OS=Caenorhabditis elegans GN=R08D7.1 PE=3 SV=1 PF04139//PF01176 Rad9//Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413//GO:0000077 regulation of translational initiation//translational initiation//DNA damage checkpoint GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840//GO:0030896 ribosome//checkpoint clamp complex KOG2654 Uncharacterized conserved protein Cluster-8309.50067 BP_3 81.82 0.81 5182 91083631 XP_970382.1 3673 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 2.06143e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2881 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF01752//PF02826//PF03188//PF00205//PF00236//PF00107//PF02233//PF02456//PF00005 Collagenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Thiamine pyrophosphate enzyme, central domain//Glycoprotein hormone//Zinc-binding dehydrogenase//NAD(P) transhydrogenase beta subunit//Adenovirus IVa2 protein//ABC transporter GO:0007165//GO:0019083//GO:0046497//GO:0006769//GO:0015992//GO:0055114//GO:0006508 signal transduction//viral transcription//nicotinate nucleotide metabolic process//nicotinamide metabolic process//proton transport//oxidation-reduction process//proteolysis GO:0005524//GO:0008750//GO:0008270//GO:0016887//GO:0004252//GO:0050661//GO:0051287//GO:0005179//GO:0000287//GO:0030976 ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//zinc ion binding//ATPase activity//serine-type endopeptidase activity//NADP binding//NAD binding//hormone activity//magnesium ion binding//thiamine pyrophosphate binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.50070 BP_3 92.86 1.82 2755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50072 BP_3 68.26 9.75 629 642917454 XP_008191207.1 338 2.6e-29 PREDICTED: uncharacterized protein LOC655754 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14722 Ki-ras-induced actin-interacting protein-IP3R-interacting domain GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.50073 BP_3 686.89 11.94 3065 91079466 XP_967409.1 421 3.0e-38 PREDICTED: uncharacterized protein LOC655754 isoform X3 [Tribolium castaneum]>gi|270003452|gb|EEZ99899.1| hypothetical protein TcasGA2_TC002683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14722 Ki-ras-induced actin-interacting protein-IP3R-interacting domain GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.50074 BP_3 132.00 6.67 1245 546685212 ERL94739.1 1007 1.4e-106 hypothetical protein D910_12013 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N954 397 3.1e-37 G patch domain-containing protein 11 OS=Homo sapiens GN=GPATCH11 PE=1 SV=3 PF01585//PF08941 G-patch domain//USP8 interacting GO:0016567 protein ubiquitination GO:0016881//GO:0031386//GO:0003676 acid-amino acid ligase activity//protein tag//nucleic acid binding -- -- KOG1994 Predicted RNA binding protein, contains G-patch and Zn-finger domains Cluster-8309.50075 BP_3 55.94 0.57 5017 546677102 ERL88003.1 1067 6.1e-113 hypothetical protein D910_05392 [Dendroctonus ponderosae] -- -- -- -- -- K16751 C2CD3 C2 domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16751 Q4AC94 264 3.3e-21 C2 domain-containing protein 3 OS=Homo sapiens GN=C2CD3 PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50077 BP_3 13.28 0.34 2153 270015676 EFA12124.1 345 1.4e-29 hypothetical protein TcasGA2_TC002270 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50078 BP_3 101.54 1.16 4512 189239531 XP_975588.2 1723 4.7e-189 PREDICTED: myb-related protein B isoform X1 [Tribolium castaneum] 817200908 XM_012420764.1 89 6.87286e-36 PREDICTED: Orussus abietinus myb-related protein B (LOC105697441), transcript variant X2, mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 P01103 467 8.5e-45 Transcriptional activator Myb OS=Gallus gallus GN=MYB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0048 Transcription factor, Myb superfamily Cluster-8309.50079 BP_3 326.62 3.16 5280 270014457 EFA10905.1 248 6.0e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.50080 BP_3 43.36 0.41 5422 270014457 EFA10905.1 248 6.2e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098//PF07776 C2H2 zinc-finger//Zinc knuckle//Zinc-finger associated domain (zf-AD) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.50082 BP_3 583.66 6.56 4578 91089365 XP_973210.1 1738 8.7e-191 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Tribolium castaneum]>gi|642933115|ref|XP_008197263.1| PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Tribolium castaneum]>gi|270012525|gb|EFA08973.1| hypothetical protein TcasGA2_TC006680 [Tribolium castaneum] 642933114 XM_008199041.1 278 6.01137e-141 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC661989), transcript variant X2, mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 Q9XZV3 959 7.7e-102 Guanine nucleotide-binding protein G(o) subunit alpha OS=Geodia cydonium PE=2 SV=3 PF07931//PF08477//PF00025//PF04670//PF00503 Chloramphenicol phosphotransferase-like protein//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0005524//GO:0031683//GO:0016740//GO:0003924//GO:0005525//GO:0004871//GO:0019001 ATP binding//G-protein beta/gamma-subunit complex binding//transferase activity//GTPase activity//GTP binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.50084 BP_3 4.94 0.44 828 91094899 XP_973315.1 576 8.7e-57 PREDICTED: ubiquitin-like modifier-activating enzyme 5 [Tribolium castaneum]>gi|270006537|gb|EFA02985.1| hypothetical protein TcasGA2_TC010401 [Tribolium castaneum] -- -- -- -- -- K12164 UBA5, UBE1DC1 ubiquitin-like modifier-activating enzyme 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12164 B9VJ80 530 7.7e-53 Ubiquitin-like modifier-activating enzyme 5 OS=Bombyx mori PE=2 SV=1 PF03435//PF02558//PF02826//PF03721//PF00899//PF00831//PF01494//PF02737 Saccharopine dehydrogenase NADP binding domain//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//ThiF family//Ribosomal L29 protein//FAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0018874//GO:0006633//GO:0006412//GO:0006631//GO:0006552//GO:0015940//GO:0006574//GO:0006550//GO:0006568//GO:0006554//GO:0055114//GO:0042254 benzoate metabolic process//fatty acid biosynthetic process//translation//fatty acid metabolic process//leucine catabolic process//pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process//tryptophan metabolic process//lysine catabolic process//oxidation-reduction process//ribosome biogenesis GO:0016491//GO:0051287//GO:0008677//GO:0008641//GO:0071949//GO:0016616//GO:0003735//GO:0000166//GO:0003857//GO:0048037 oxidoreductase activity//NAD binding//2-dehydropantoate 2-reductase activity//small protein activating enzyme activity//FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural constituent of ribosome//nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity//cofactor binding GO:0005622//GO:0005840 intracellular//ribosome KOG2336 Molybdopterin biosynthesis-related protein Cluster-8309.50087 BP_3 31.32 3.13 774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50089 BP_3 162.06 2.46 3469 91083357 XP_975102.1 2572 1.3e-287 PREDICTED: suppressor of hairless protein [Tribolium castaneum]>gi|270008236|gb|EFA04684.1| suppressor of hairless [Tribolium castaneum] 642923838 XM_970009.2 512 0 PREDICTED: Tribolium castaneum suppressor of hairless (LOC663984), mRNA K06053 RBPSUH, RBPJK recombining binding protein suppressor of hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06053 P28159 2150 4.6e-240 Suppressor of hairless protein OS=Drosophila melanogaster GN=Su(H) PE=1 SV=1 PF09271//PF09270//PF01833 LAG1, DNA binding//Beta-trefoil DNA-binding domain//IPT/TIG domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0003700//GO:0000978//GO:0000982 protein binding//DNA binding//transcription factor activity, sequence-specific DNA binding//RNA polymerase II core promoter proximal region sequence-specific DNA binding//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3743 Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5) Cluster-8309.50090 BP_3 6.47 0.64 776 91088745 XP_975314.1 302 4.8e-25 PREDICTED: uncharacterized protein LOC664209 [Tribolium castaneum]>gi|270012304|gb|EFA08752.1| hypothetical protein TcasGA2_TC006429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50091 BP_3 6.17 0.70 715 332373440 AEE61861.1 334 8.7e-29 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GQ29 299 4.1e-26 Carboxypeptidase Q OS=Xenopus laevis GN=cpq PE=2 SV=1 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.50092 BP_3 286.75 2.51 5796 642927212 XP_008195182.1 2177 1.4e-241 PREDICTED: S phase cyclin A-associated protein in the endoplasmic reticulum [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY12 677 4.9e-69 S phase cyclin A-associated protein in the endoplasmic reticulum OS=Homo sapiens GN=SCAPER PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50096 BP_3 16.74 0.94 1150 514683686 XP_004989424.1 195 1.8e-12 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86T29 136 5.2e-07 Zinc finger protein 605 OS=Homo sapiens GN=ZNF605 PE=2 SV=1 PF02150//PF04988//PF13465 RNA polymerases M/15 Kd subunit//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003899//GO:0003677 metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.50098 BP_3 8.46 0.52 1078 260832616 XP_002611253.1 217 4.8e-15 hypothetical protein BRAFLDRAFT_71208 [Branchiostoma floridae]>gi|229296624|gb|EEN67263.1| hypothetical protein BRAFLDRAFT_71208 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q96JM2 155 3.1e-09 Zinc finger protein 462 OS=Homo sapiens GN=ZNF462 PE=1 SV=3 PF02150//PF13465//PF00096 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//metal ion binding GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.50099 BP_3 55.56 2.58 1330 91085455 XP_969485.1 152 2.0e-07 PREDICTED: WASH complex subunit FAM21A [Tribolium castaneum]>gi|270009171|gb|EFA05619.1| hypothetical protein TcasGA2_TC015827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5010 BP_3 25.82 0.93 1633 769831193 XP_011634997.1 1729 3.4e-190 PREDICTED: synaptotagmin-7 isoform X1 [Pogonomyrmex barbatus] 768417764 XM_011551234.1 440 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 876 1.2e-92 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.50100 BP_3 63.40 2.38 1573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50101 BP_3 14.60 0.48 1762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50102 BP_3 3441.01 30.53 5724 270013632 EFA10080.1 4350 0.0e+00 hypothetical protein TcasGA2_TC012257 [Tribolium castaneum] 462320691 APGK01043568.1 65 1.91749e-22 Dendroctonus ponderosae Seq01043578, whole genome shotgun sequence K16680 ED echinoid http://www.genome.jp/dbget-bin/www_bget?ko:K16680 Q96RW7 345 1.5e-30 Hemicentin-1 OS=Homo sapiens GN=HMCN1 PE=1 SV=2 PF01108//PF06682//PF13895//PF00041 Tissue factor//SOCE-associated regulatory factor of calcium homoeostasis//Immunoglobulin domain//Fibronectin type III domain GO:2001256 regulation of store-operated calcium entry GO:0005515 protein binding GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.50103 BP_3 77.65 1.16 3525 642923441 XP_008193745.1 3178 0.0e+00 PREDICTED: intraflagellar transport protein 80 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2H3 1990 1.7e-221 Intraflagellar transport protein 80 homolog OS=Homo sapiens GN=IFT80 PE=1 SV=3 PF04421//PF00400//PF01239 Mss4 protein//WD domain, G-beta repeat//Protein prenyltransferase alpha subunit repeat GO:0043087//GO:0018342//GO:0007264 regulation of GTPase activity//protein prenylation//small GTPase mediated signal transduction GO:0005085//GO:0008318//GO:0005515 guanyl-nucleotide exchange factor activity//protein prenyltransferase activity//protein binding -- -- KOG0529 Protein geranylgeranyltransferase type II, alpha subunit Cluster-8309.50105 BP_3 830.00 21.56 2147 91087583 XP_971811.1 2038 6.7e-226 PREDICTED: nicalin-1 [Tribolium castaneum]>gi|270009431|gb|EFA05879.1| hypothetical protein TcasGA2_TC008691 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NZ07 1167 2.7e-126 Nicalin-1 OS=Danio rerio GN=ncl1 PE=2 SV=1 PF05450 Nicastrin GO:0016485//GO:0006508 protein processing//proteolysis GO:0008233 peptidase activity GO:0016021 integral component of membrane KOG2526 Predicted aminopeptidases - M20/M25/M40 family Cluster-8309.50106 BP_3 208.32 3.69 3014 642916479 XP_008191061.1 1715 2.7e-188 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TUF1 1179 1.6e-127 Serrate RNA effector molecule homolog OS=Anopheles gambiae GN=Ars2 PE=3 SV=3 PF00076//PF09726 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding GO:0016021 integral component of membrane KOG2295 C2H2 Zn-finger protein Cluster-8309.50108 BP_3 214.35 2.08 5249 642931184 XP_008196473.1 2454 9.4e-274 PREDICTED: mediator of RNA polymerase II transcription subunit 1 [Tribolium castaneum]>gi|270012110|gb|EFA08558.1| hypothetical protein TcasGA2_TC006213 [Tribolium castaneum] -- -- -- -- -- K15144 MED1 mediator of RNA polymerase II transcription subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15144 Q172G3 1280 5.3e-139 Mediator of RNA polymerase II transcription subunit 1 OS=Aedes aegypti GN=AAEL007402 PE=3 SV=1 PF04810//PF10744 Sec23/Sec24 zinc finger//Mediator of RNA polymerase II transcription subunit 1 GO:0006886//GO:0006888//GO:0006357 intracellular protein transport//ER to Golgi vesicle-mediated transport//regulation of transcription from RNA polymerase II promoter GO:0008270//GO:0001104 zinc ion binding//RNA polymerase II transcription cofactor activity GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.5011 BP_3 1.00 0.90 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50110 BP_3 134.35 1.36 5046 642935053 XP_008199922.1 1091 1.0e-115 PREDICTED: cerebellar degeneration-related protein 2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 347 7.8e-31 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF01025//PF02183//PF04977//PF16326//PF06156//PF10473//PF07926 GrpE//Homeobox associated leucine zipper//Septum formation initiator//ABC transporter C-terminal domain//Protein of unknown function (DUF972)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein GO:0006606//GO:0006355//GO:0006260//GO:0007049//GO:0006457 protein import into nucleus//regulation of transcription, DNA-templated//DNA replication//cell cycle//protein folding GO:0043565//GO:0042803//GO:0051087//GO:0000774//GO:0003700//GO:0003677//GO:0008134//GO:0045502 sequence-specific DNA binding//protein homodimerization activity//chaperone binding//adenyl-nucleotide exchange factor activity//transcription factor activity, sequence-specific DNA binding//DNA binding//transcription factor binding//dynein binding GO:0030286//GO:0005667 dynein complex//transcription factor complex -- -- Cluster-8309.50112 BP_3 28.00 4.48 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50114 BP_3 541.90 7.04 4003 91088329 XP_970397.1 411 5.7e-37 PREDICTED: geminin [Tribolium castaneum]>gi|270012171|gb|EFA08619.1| hypothetical protein TcasGA2_TC006282 [Tribolium castaneum] -- -- -- -- -- K10749 GMNN geminin http://www.genome.jp/dbget-bin/www_bget?ko:K10749 -- -- -- -- PF00833//PF07412//PF00714//PF06456 Ribosomal S17//Geminin//Interferon gamma//Arfaptin-like domain GO:0006275//GO:0007165//GO:0006412//GO:0006955//GO:0042254 regulation of DNA replication//signal transduction//translation//immune response//ribosome biogenesis GO:0019904//GO:0005133//GO:0003735 protein domain specific binding//interferon-gamma receptor binding//structural constituent of ribosome GO:0005622//GO:0005840//GO:0005576 intracellular//ribosome//extracellular region -- -- Cluster-8309.50116 BP_3 129850.25 4962.23 1553 478260764 ENN80437.1 252 6.1e-19 hypothetical protein YQE_03141, partial [Dendroctonus ponderosae] 642925806 XM_964316.3 202 3.55878e-99 PREDICTED: Tribolium castaneum glycine-rich cell wall structural protein (LOC657888), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50120 BP_3 67.93 1.01 3537 270014279 EFA10727.1 1613 2.1e-176 cappuccino [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 781 2.6e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.50122 BP_3 65.45 0.96 3572 91081013 XP_975219.1 1786 1.8e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 2.2e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.50123 BP_3 16.63 3.15 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50124 BP_3 69.66 5.16 942 642927700 XP_008196611.1 411 1.3e-37 PREDICTED: LOW QUALITY PROTEIN: oxidative stress-induced growth inhibitor 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y236 229 7.0e-18 Oxidative stress-induced growth inhibitor 2 OS=Homo sapiens GN=OSGIN2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50129 BP_3 60.74 0.33 9298 642912276 XP_008200634.1 5209 0.0e+00 PREDICTED: exportin-7 isoform X2 [Tribolium castaneum]>gi|270002549|gb|EEZ98996.1| hypothetical protein TcasGA2_TC004857 [Tribolium castaneum] 642912275 XM_008202412.1 982 0 PREDICTED: Tribolium castaneum exportin-7 (LOC655656), transcript variant X2, mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 4020 0.0e+00 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 PF13414//PF03810 TPR repeat//Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008565//GO:0005515//GO:0008536 protein transporter activity//protein binding//Ran GTPase binding GO:0005643 nuclear pore KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.50131 BP_3 3407.24 20.33 8371 91080871 XP_972325.1 4869 0.0e+00 PREDICTED: nidogen-1 [Tribolium castaneum]>gi|270005920|gb|EFA02368.1| hypothetical protein TcasGA2_TC008043 [Tribolium castaneum] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 4.1e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF07645//PF00008//PF02257//PF06119 Calcium-binding EGF domain//EGF-like domain//RFX DNA-binding domain//Nidogen-like GO:0007160//GO:0006355 cell-matrix adhesion//regulation of transcription, DNA-templated GO:0003677//GO:0005509//GO:0005515 DNA binding//calcium ion binding//protein binding -- -- KOG1214 Nidogen and related basement membrane protein proteins Cluster-8309.50137 BP_3 24.55 0.80 1763 646721584 KDR22862.1 383 4.4e-34 Transcription initiation factor TFIID subunit 4 [Zootermopsis nevadensis] 642914704 XM_961439.3 98 2.63545e-41 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K03129 TAF4 transcription initiation factor TFIID subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50138 BP_3 15.51 2.18 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.50139 BP_3 366.21 3.22 5781 642914701 XP_008199886.1 2077 5.4e-230 PREDICTED: transcription initiation factor TFIID subunit 4 isoform X1 [Tribolium castaneum] 642914704 XM_961439.3 141 1.0937e-64 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K03129 TAF4 transcription initiation factor TFIID subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03129 O00268 702 6.1e-72 Transcription initiation factor TFIID subunit 4 OS=Homo sapiens GN=TAF4 PE=1 SV=2 PF05236//PF07531 Transcription initiation factor TFIID component TAF4 family//NHR1 homology to TAF GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005669//GO:0005667 transcription factor TFIID complex//transcription factor complex KOG2341 TATA box binding protein (TBP)-associated factor, RNA polymerase II Cluster-8309.5014 BP_3 5.75 0.38 1020 91079462 XP_966980.1 303 4.9e-25 PREDICTED: uncharacterized protein LOC655346 [Tribolium castaneum]>gi|270003455|gb|EEZ99902.1| hypothetical protein TcasGA2_TC002686 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50140 BP_3 15.49 2.18 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.50141 BP_3 194.60 1.07 9047 91077944 XP_966624.1 1709 4.0e-187 PREDICTED: U3 small nucleolar RNA-associated protein 18 homolog [Tribolium castaneum]>gi|270001438|gb|EEZ97885.1| hypothetical protein TcasGA2_TC000267 [Tribolium castaneum] 642914704 XM_961439.3 98 1.37329e-40 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K14553 UTP18 U3 small nucleolar RNA-associated protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K14553 Q9V7P1 823 8.9e-86 U3 small nucleolar RNA-associated protein 18 homolog OS=Drosophila melanogaster GN=wcd PE=1 SV=1 PF00400//PF05434 WD domain, G-beta repeat//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2055 WD40 repeat protein Cluster-8309.50143 BP_3 378.72 2.08 9083 91077944 XP_966624.1 1709 4.0e-187 PREDICTED: U3 small nucleolar RNA-associated protein 18 homolog [Tribolium castaneum]>gi|270001438|gb|EEZ97885.1| hypothetical protein TcasGA2_TC000267 [Tribolium castaneum] 642914704 XM_961439.3 98 1.37878e-40 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K14553 UTP18 U3 small nucleolar RNA-associated protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K14553 Q9V7P1 823 9.0e-86 U3 small nucleolar RNA-associated protein 18 homolog OS=Drosophila melanogaster GN=wcd PE=1 SV=1 PF00400//PF05434 WD domain, G-beta repeat//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2055 WD40 repeat protein Cluster-8309.50145 BP_3 244.79 2.15 5770 642914701 XP_008199886.1 2077 5.4e-230 PREDICTED: transcription initiation factor TFIID subunit 4 isoform X1 [Tribolium castaneum] 642914704 XM_961439.3 141 1.0916e-64 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K03129 TAF4 transcription initiation factor TFIID subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03129 O00268 702 6.1e-72 Transcription initiation factor TFIID subunit 4 OS=Homo sapiens GN=TAF4 PE=1 SV=2 PF07531//PF05236 NHR1 homology to TAF//Transcription initiation factor TFIID component TAF4 family GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005669//GO:0005667 transcription factor TFIID complex//transcription factor complex KOG2341 TATA box binding protein (TBP)-associated factor, RNA polymerase II Cluster-8309.50146 BP_3 37.00 4.64 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50147 BP_3 341.85 2.30 7469 642940394 XP_008200544.1 720 1.6e-72 PREDICTED: chitin deacetylase 5 isoform X5 [Tribolium castaneum] 642940399 XM_008202325.1 70 4.16158e-25 PREDICTED: Tribolium castaneum chitin deacetylase 5 (Cda5), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.50148 BP_3 21.01 0.48 2423 91091868 XP_969098.1 1369 2.8e-148 PREDICTED: 26S proteasome non-ATPase regulatory subunit 5 [Tribolium castaneum]>gi|270001117|gb|EEZ97564.1| hypothetical protein TcasGA2_TC011419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16401 632 3.4e-64 26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens GN=PSMD5 PE=1 SV=3 PF00514//PF11698//PF10508//PF02985 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Proteasome non-ATPase 26S subunit//HEAT repeat GO:0043248//GO:0015991 proteasome assembly//ATP hydrolysis coupled proton transport GO:0005515//GO:0016820 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.5015 BP_3 39.27 0.95 2278 642918256 XP_008191433.1 1117 4.4e-119 PREDICTED: low affinity cationic amino acid transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50150 BP_3 457.32 6.74 3563 642921224 XP_008192769.1 1938 4.4e-214 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921223 XM_008194547.1 369 0 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X1, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 677 3.0e-69 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF14604//PF00018//PF00023//PF03396//PF13606 Variant SH3 domain//SH3 domain//Ankyrin repeat//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Ankyrin repeat GO:0006144//GO:0006351//GO:0019083//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//viral transcription//pyrimidine nucleobase metabolic process GO:0005515//GO:0003899//GO:0003677 protein binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.50152 BP_3 7.73 0.99 668 801402421 XP_012061378.1 424 3.0e-39 PREDICTED: vacuolar protein sorting-associated protein 29 [Atta cephalotes] -- -- -- -- -- K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 389 1.4e-36 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.50153 BP_3 114.18 1.33 4416 270009849 EFA06297.1 1025 4.0e-108 hypothetical protein TcasGA2_TC009164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5VW36 239 2.3e-18 Focadhesin OS=Homo sapiens GN=FOCAD PE=1 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50155 BP_3 72.68 0.68 5431 665804096 XP_008550173.1 2041 7.6e-226 PREDICTED: potassium voltage-gated channel protein Shab isoform X2 [Microplitis demolitor] 795009898 XM_012008789.1 149 3.66794e-69 PREDICTED: Vollenhovia emeryi potassium voltage-gated channel protein Shab-like (LOC105560041), mRNA K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1859 4.0e-206 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF13374//PF02214//PF00520//PF01092 Tetratricopeptide repeat//BTB/POZ domain//Ion transport protein//Ribosomal protein S6e GO:0055085//GO:0006412//GO:0051260//GO:0006811//GO:0042254 transmembrane transport//translation//protein homooligomerization//ion transport//ribosome biogenesis GO:0005515//GO:0005216//GO:0003735 protein binding//ion channel activity//structural constituent of ribosome GO:0016020//GO:0005622//GO:0005840 membrane//intracellular//ribosome -- -- Cluster-8309.50156 BP_3 6.14 0.36 1114 642917930 XP_008200653.1 558 1.4e-54 PREDICTED: uncharacterized protein LOC103314985, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50158 BP_3 50.06 0.99 2721 642919246 XP_008191792.1 510 1.3e-48 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 312 4.8e-27 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50159 BP_3 169.34 3.77 2457 642919246 XP_008191792.1 900 6.9e-94 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 533 1.0e-52 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50160 BP_3 70.20 0.83 4366 642935245 XP_008197928.1 1932 2.7e-213 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 308 1.20589e-157 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 830 6.7e-87 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF16990//PF13895//PF04110//PF05790 Carbohydrate binding module (family 35)//Immunoglobulin domain//Ubiquitin-like autophagy protein Apg12//Immunoglobulin C2-set domain GO:0000045//GO:0007155 autophagosome assembly//cell adhesion GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.50161 BP_3 11.43 0.50 1384 642935247 XP_008197929.1 711 3.2e-72 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] -- -- -- -- -- K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9VS29 373 2.1e-34 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50163 BP_3 20.87 0.38 2918 642935245 XP_008197928.1 698 2.2e-70 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] -- -- -- -- -- K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9VS29 379 8.8e-35 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF05786 Immunoglobulin domain//Condensin complex subunit 2 GO:0007076 mitotic chromosome condensation GO:0005515 protein binding GO:0000796 condensin complex -- -- Cluster-8309.50164 BP_3 161.81 2.75 3127 91079786 XP_967971.1 1583 5.6e-173 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 6.8e-126 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607//PF16093 Chitin binding Peritrophin-A domain//Proteasome assembly chaperone 4 GO:0006030//GO:0043248//GO:0042254//GO:0006396 chitin metabolic process//proteasome assembly//ribosome biogenesis//RNA processing GO:0003824//GO:0008061 catalytic activity//chitin binding GO:0005576//GO:0005730 extracellular region//nucleolus KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.50168 BP_3 359.73 4.76 3938 642929450 XP_008195846.1 3584 0.0e+00 PREDICTED: serine/threonine-protein kinase D3 isoform X2 [Tribolium castaneum] 242010804 XM_002426104.1 343 3.79938e-177 Pediculus humanus corporis serine/threonine-protein kinase D1, putative, mRNA K06070 PKD protein kinase D http://www.genome.jp/dbget-bin/www_bget?ko:K06070 O94806 2295 8.0e-257 Serine/threonine-protein kinase D3 OS=Homo sapiens GN=PRKD3 PE=1 SV=1 PF06293//PF01155//PF00130//PF05445//PF00069//PF16866//PF07714//PF07649//PF00628 Lipopolysaccharide kinase (Kdo/WaaP) family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//Poxvirus serine/threonine protein kinase//Protein kinase domain//PHD-finger//Protein tyrosine kinase//C1-like domain//PHD-finger GO:0006464//GO:0006468//GO:0055114//GO:0035556 cellular protein modification process//protein phosphorylation//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0016151//GO:0016773//GO:0004672//GO:0047134 ATP binding//protein binding//nickel cation binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein-disulfide reductase activity GO:0016020 membrane KOG4236 Serine/threonine protein kinase PKC mu/PKD and related proteins Cluster-8309.5017 BP_3 3.00 0.31 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50170 BP_3 612.81 7.29 4344 91078200 XP_968428.1 1153 5.7e-123 PREDICTED: m7GpppN-mRNA hydrolase [Tribolium castaneum]>gi|270001356|gb|EEZ97803.1| hypothetical protein TcasGA2_TC000167 [Tribolium castaneum] -- -- -- -- -- K12613 DCP2 mRNA-decapping enzyme subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12613 Q5REQ8 712 3.2e-73 m7GpppN-mRNA hydrolase OS=Pongo abelii GN=DCP2 PE=2 SV=1 PF05026//PF08273//PF15957//PF00293 Dcp2, box A domain//Zinc-binding domain of primase-helicase//Commissureless//NUDIX domain GO:0006351//GO:0007411//GO:0006269 transcription, DNA-templated//axon guidance//DNA replication, synthesis of RNA primer GO:0003896//GO:0016787//GO:0004386//GO:0003723//GO:0030145//GO:0008270 DNA primase activity//hydrolase activity//helicase activity//RNA binding//manganese ion binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG2937 Decapping enzyme complex, predicted pyrophosphatase DCP2 Cluster-8309.50171 BP_3 326.77 6.18 2842 91078200 XP_968428.1 1053 1.5e-111 PREDICTED: m7GpppN-mRNA hydrolase [Tribolium castaneum]>gi|270001356|gb|EEZ97803.1| hypothetical protein TcasGA2_TC000167 [Tribolium castaneum] -- -- -- -- -- K12613 DCP2 mRNA-decapping enzyme subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12613 Q5REQ8 710 3.6e-73 m7GpppN-mRNA hydrolase OS=Pongo abelii GN=DCP2 PE=2 SV=1 PF05026//PF00293//PF15957//PF08273 Dcp2, box A domain//NUDIX domain//Commissureless//Zinc-binding domain of primase-helicase GO:0006269//GO:0006351//GO:0007411 DNA replication, synthesis of RNA primer//transcription, DNA-templated//axon guidance GO:0008270//GO:0016787//GO:0003896//GO:0004386//GO:0003723//GO:0030145 zinc ion binding//hydrolase activity//DNA primase activity//helicase activity//RNA binding//manganese ion binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2937 Decapping enzyme complex, predicted pyrophosphatase DCP2 Cluster-8309.50173 BP_3 372.44 2.73 6861 478253900 ENN74192.1 2763 1.8e-309 hypothetical protein YQE_09165, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 2.05361e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1647 1.9e-181 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.50175 BP_3 67.19 0.43 7848 478254383 ENN74635.1 2600 1.7e-290 hypothetical protein YQE_08755, partial [Dendroctonus ponderosae] -- -- -- -- -- K02350 POLZ1, rev3 DNA polymerase zeta http://www.genome.jp/dbget-bin/www_bget?ko:K02350 O60673 1976 1.6e-219 DNA polymerase zeta catalytic subunit OS=Homo sapiens GN=REV3L PE=1 SV=2 PF13683//PF00136//PF03104//PF02741 Integrase core domain//DNA polymerase family B//DNA polymerase family B, exonuclease domain//FTR, proximal lobe GO:0015074//GO:0006730 DNA integration//one-carbon metabolic process GO:0000166//GO:0008408//GO:0003677//GO:0016740 nucleotide binding//3'-5' exonuclease activity//DNA binding//transferase activity -- -- KOG0968 DNA polymerase zeta, catalytic subunit Cluster-8309.50176 BP_3 261.00 25.87 778 226968618 YP_002808567.1 1066 1.2e-113 cytochrome c oxidase subunit III [Scylla paramamosain]>gi|225697854|gb|ACO07221.1| cytochrome c oxidase subunit III [Scylla paramamosain]>gi|403311093|gb|AFR34052.1| cytochrome c oxidase subunit III (mitochondrion) [Scylla paramamosain] 225697849 FJ827761.1 776 0 Scylla paramamosain mitochondrion, complete genome K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 B0FWD1 850 5.7e-90 Cytochrome c oxidase subunit 3 OS=Aedes aegypti GN=mt:CoIII PE=3 SV=1 -- -- GO:0006123//GO:0019646//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//aerobic electron transport chain//proton transport GO:0004129 cytochrome-c oxidase activity GO:0016021//GO:0045277//GO:0005739 integral component of membrane//respiratory chain complex IV//mitochondrion KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-8309.50177 BP_3 58.04 0.52 5646 189237952 XP_001813626.1 2230 9.6e-248 PREDICTED: methyltransferase-like protein 13 [Tribolium castaneum]>gi|270008036|gb|EFA04484.1| hypothetical protein TcasGA2_TC014789 [Tribolium castaneum] 332372815 BT126586.1 117 2.34475e-51 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q9VIK9 1576 2.7e-173 Methyltransferase-like protein 13 OS=Drosophila melanogaster GN=CG2614 PE=2 SV=1 PF07516//PF00025//PF05175//PF08477//PF05724//PF08241//PF02390//PF01926//PF00503//PF01209//PF00071//PF10662//PF04670//PF03193//PF00005 SecA Wing and Scaffold domain//ADP-ribosylation factor family//Methyltransferase small domain//Ras of Complex, Roc, domain of DAPkinase//Thiopurine S-methyltransferase (TPMT)//Methyltransferase domain//Putative methyltransferase//50S ribosome-binding GTPase//G-protein alpha subunit//ubiE/COQ5 methyltransferase family//Ras family//Ethanolamine utilisation - propanediol utilisation//Gtr1/RagA G protein conserved region//Protein of unknown function, DUF258//ABC transporter GO:0007165//GO:0017038//GO:0008033//GO:0007186//GO:0008152//GO:0006576//GO:0032259//GO:0007264//GO:0006400//GO:0009451 signal transduction//protein import//tRNA processing//G-protein coupled receptor signaling pathway//metabolic process//cellular biogenic amine metabolic process//methylation//small GTPase mediated signal transduction//tRNA modification//RNA modification GO:0003924//GO:0005524//GO:0031683//GO:0008168//GO:0016887//GO:0019001//GO:0008757//GO:0005525//GO:0004871//GO:0008176 GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//methyltransferase activity//ATPase activity//guanyl nucleotide binding//S-adenosylmethionine-dependent methyltransferase activity//GTP binding//signal transducer activity//tRNA (guanine-N7-)-methyltransferase activity GO:0016020 membrane KOG3886 GTP-binding protein Cluster-8309.50178 BP_3 96.63 0.84 5836 189237952 XP_001813626.1 2230 9.9e-248 PREDICTED: methyltransferase-like protein 13 [Tribolium castaneum]>gi|270008036|gb|EFA04484.1| hypothetical protein TcasGA2_TC014789 [Tribolium castaneum] 332372815 BT126586.1 117 2.42416e-51 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q9VIK9 1576 2.8e-173 Methyltransferase-like protein 13 OS=Drosophila melanogaster GN=CG2614 PE=2 SV=1 PF00503//PF01209//PF04670//PF00071//PF10662//PF00005//PF03193//PF07516//PF00025//PF08241//PF02390//PF08477//PF05175//PF05724//PF01926 G-protein alpha subunit//ubiE/COQ5 methyltransferase family//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//ABC transporter//Protein of unknown function, DUF258//SecA Wing and Scaffold domain//ADP-ribosylation factor family//Methyltransferase domain//Putative methyltransferase//Ras of Complex, Roc, domain of DAPkinase//Methyltransferase small domain//Thiopurine S-methyltransferase (TPMT)//50S ribosome-binding GTPase GO:0007165//GO:0017038//GO:0008033//GO:0007186//GO:0008152//GO:0006576//GO:0032259//GO:0006400//GO:0007264//GO:0009451 signal transduction//protein import//tRNA processing//G-protein coupled receptor signaling pathway//metabolic process//cellular biogenic amine metabolic process//methylation//tRNA modification//small GTPase mediated signal transduction//RNA modification GO:0003924//GO:0005524//GO:0031683//GO:0008168//GO:0016887//GO:0019001//GO:0008757//GO:0005525//GO:0004871//GO:0008176 GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//methyltransferase activity//ATPase activity//guanyl nucleotide binding//S-adenosylmethionine-dependent methyltransferase activity//GTP binding//signal transducer activity//tRNA (guanine-N7-)-methyltransferase activity GO:0016020 membrane KOG3886 GTP-binding protein Cluster-8309.50179 BP_3 686.40 6.39 5468 383847785 XP_003699533.1 2153 7.9e-239 PREDICTED: serine/threonine-protein phosphatase 5 isoform X1 [Megachile rotundata] 817223205 XM_012431486.1 202 1.27307e-98 PREDICTED: Orussus abietinus serine/threonine-protein phosphatase 5 (LOC105703243), transcript variant X2, mRNA K04460 PPP5C serine/threonine-protein phosphatase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04460 P53041 1825 3.5e-202 Serine/threonine-protein phosphatase 5 OS=Homo sapiens GN=PPP5C PE=1 SV=1 PF13181//PF13174//PF13371//PF00515//PF00149//PF01553//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Calcineurin-like phosphoesterase//Acyltransferase//Tetratricopeptide repeat//TPR repeat GO:0008152 metabolic process GO:0016746//GO:0005515//GO:0016787 transferase activity, transferring acyl groups//protein binding//hydrolase activity -- -- KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.50183 BP_3 61.51 2.68 1399 524901033 XP_005106931.1 651 3.0e-65 PREDICTED: ras-related protein Rab-1A [Aplysia californica] -- -- -- -- -- K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q05974 647 3.5e-66 Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1 PF00071//PF00025//PF08477//PF03193//PF01926 Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.50185 BP_3 264.00 35.51 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50186 BP_3 31.68 0.91 1966 189242016 XP_001807518.1 1879 1.7e-207 PREDICTED: carboxypeptidase E-like [Tribolium castaneum] 37787288 AY214171.1 41 1.42961e-09 Paralichthys olivaceus carboxypeptidase H mRNA, complete cds K01294 CPE carboxypeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01294 P37892 1035 5.1e-111 Carboxypeptidase E OS=Lophius americanus GN=cpe PE=2 SV=1 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016788//GO:0008270//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//metallocarboxypeptidase activity -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.50188 BP_3 65.85 1.48 2437 332374348 AEE62315.1 987 5.6e-104 unknown [Dendroctonus ponderosae]>gi|478251260|gb|ENN71734.1| hypothetical protein YQE_11656, partial [Dendroctonus ponderosae]>gi|546676119|gb|ERL87186.1| hypothetical protein D910_04586 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W5U2 149 3.4e-08 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.50190 BP_3 112.93 1.48 3981 642923836 XP_008193900.1 2217 2.2e-246 PREDICTED: LOW QUALITY PROTEIN: DNA repair protein complementing XP-G cells homolog [Tribolium castaneum] -- -- -- -- -- K10846 ERCC5, XPG, RAD2 DNA excision repair protein ERCC-5 http://www.genome.jp/dbget-bin/www_bget?ko:K10846 P28715 623 6.1e-63 DNA repair protein complementing XP-G cells OS=Homo sapiens GN=ERCC5 PE=1 SV=3 PF00867//PF00752 XPG I-region//XPG N-terminal domain GO:0006281 DNA repair GO:0004518 nuclease activity -- -- KOG2520 5'-3' exonuclease Cluster-8309.50191 BP_3 67.64 2.08 1861 642928561 XP_008199958.1 1171 2.0e-125 PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928563|ref|XP_008199959.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928565|ref|XP_008199960.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270011133|gb|EFA07581.1| cytochrome P450 12H1 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 805 2.2e-84 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067//PF02959 Cytochrome P450//HTLV Tax GO:0055114//GO:0045893 oxidation-reduction process//positive regulation of transcription, DNA-templated GO:0005506//GO:0016491//GO:0020037//GO:0005488//GO:0016705 iron ion binding//oxidoreductase activity//heme binding//binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.50195 BP_3 1.00 0.99 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50202 BP_3 1742.63 13.27 6621 642930492 XP_008196426.1 2252 3.2e-250 PREDICTED: CLIP-associating protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 867 5.2e-91 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF02985//PF12844//PF01528 HEAT repeat//Helix-turn-helix domain//Herpesvirus glycoprotein M -- -- GO:0005515//GO:0043565 protein binding//sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.50203 BP_3 443.76 4.33 5237 642922255 XP_008193081.1 3052 0.0e+00 PREDICTED: sodium bicarbonate cotransporter 3 isoform X2 [Tribolium castaneum] 642922254 XM_008194859.1 405 0 PREDICTED: Tribolium castaneum sodium bicarbonate cotransporter 3 (LOC661759), transcript variant X4, mRNA -- -- -- -- Q8JZR6 1986 7.2e-221 Electroneutral sodium bicarbonate exchanger 1 OS=Mus musculus GN=Slc4a8 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.50204 BP_3 295.73 5.53 2868 642930150 XP_008196273.1 1719 8.7e-189 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X7 [Tribolium castaneum] 189164165 EU545256.1 259 1.36729e-130 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1247 1.9e-135 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.50206 BP_3 43.42 0.56 4049 91090772 XP_969499.1 1511 1.6e-164 PREDICTED: rapamycin-insensitive companion of mTOR [Tribolium castaneum]>gi|270013969|gb|EFA10417.1| hypothetical protein TcasGA2_TC012657 [Tribolium castaneum] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 725 9.2e-75 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.50208 BP_3 1.00 2.65 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50209 BP_3 47.82 1.72 1630 91094501 XP_971498.1 793 1.2e-81 PREDICTED: translation initiation factor eIF-2B subunit alpha [Tribolium castaneum]>gi|270000750|gb|EEZ97197.1| hypothetical protein TcasGA2_TC004385 [Tribolium castaneum] 815821379 XM_012376515.1 71 2.48479e-26 PREDICTED: Linepithema humile translation initiation factor eIF-2B subunit alpha (LOC105677712), mRNA K03239 EIF2B1 translation initiation factor eIF-2B subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03239 Q0IIF2 560 5.1e-56 Translation initiation factor eIF-2B subunit alpha OS=Bos taurus GN=EIF2B1 PE=2 SV=1 PF01008 Initiation factor 2 subunit family GO:0044237 cellular metabolic process -- -- -- -- KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) Cluster-8309.5021 BP_3 2.00 0.54 470 602715618 XP_007468010.1 677 9.6e-69 PREDICTED: 60S ribosomal protein L23-like [Lipotes vexillifer] 40226377 BC010114.2 470 0 Homo sapiens ribosomal protein L23, mRNA (cDNA clone MGC:19760 IMAGE:3632936), complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P62829 664 1.3e-68 60S ribosomal protein L23 OS=Homo sapiens GN=RPL23 PE=1 SV=1 PF00238 Ribosomal protein L14p/L23e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.50210 BP_3 231.44 12.23 1204 646700908 KDR10861.1 1083 2.0e-115 Translation initiation factor eIF-2B subunit alpha [Zootermopsis nevadensis] 815821379 XM_012376515.1 71 1.82114e-26 PREDICTED: Linepithema humile translation initiation factor eIF-2B subunit alpha (LOC105677712), mRNA K03239 EIF2B1 translation initiation factor eIF-2B subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03239 Q14232 819 3.5e-86 Translation initiation factor eIF-2B subunit alpha OS=Homo sapiens GN=EIF2B1 PE=1 SV=1 PF01008 Initiation factor 2 subunit family GO:0044237 cellular metabolic process -- -- -- -- KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) Cluster-8309.50211 BP_3 186.00 3.59 2786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0009405//GO:0019835 pathogenesis//cytolysis -- -- GO:0019867 outer membrane -- -- Cluster-8309.50216 BP_3 168.62 5.79 1695 642913503 XP_008201041.1 1467 8.6e-160 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 Q91YJ2 811 4.1e-85 Sorting nexin-4 OS=Mus musculus GN=Snx4 PE=2 SV=1 PF00500//PF00787 L1 (late) protein//PX domain GO:0007154 cell communication GO:0035091//GO:0005198 phosphatidylinositol binding//structural molecule activity GO:0019028 viral capsid KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.50218 BP_3 152.76 4.05 2111 642913503 XP_008201041.1 1541 2.8e-168 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 A1A4L0 837 5.0e-88 Sorting nexin-4 OS=Bos taurus GN=SNX4 PE=2 SV=1 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.50219 BP_3 4.00 0.47 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50221 BP_3 318.13 4.21 3933 270009741 EFA06189.1 3185 0.0e+00 hypothetical protein TcasGA2_TC009038 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IGJ0 2062 8.3e-230 Protein EFR3 homolog cmp44E OS=Drosophila melanogaster GN=stmA PE=2 SV=3 PF05000//PF07244 RNA polymerase Rpb1, domain 4//Surface antigen variable number repeat GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0019867 nucleolus//outer membrane KOG1877 Putative transmembrane protein cmp44E Cluster-8309.50224 BP_3 22.77 1.98 845 91089739 XP_975135.1 570 4.4e-56 PREDICTED: S-adenosylmethionine mitochondrial carrier protein homolog [Tribolium castaneum]>gi|270012648|gb|EFA09096.1| hypothetical protein TcasGA2_TC006818 [Tribolium castaneum] -- -- -- -- -- K15111 SLC25A26 solute carrier family 25 (mitochondrial S-adenosylmethionine transporter), member 26 http://www.genome.jp/dbget-bin/www_bget?ko:K15111 Q9VBN7 347 1.3e-31 S-adenosylmethionine mitochondrial carrier protein homolog OS=Drosophila melanogaster GN=CG4743 PE=2 SV=2 PF02554//PF09515 Carbon starvation protein CstA//Thiamine transporter protein (Thia_YuaJ) GO:0009267//GO:0015888 cellular response to starvation//thiamine transport GO:0015234 thiamine transmembrane transporter activity GO:0016020//GO:0005886 membrane//plasma membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.50225 BP_3 95.87 0.76 6348 649572315 NP_001280527.1 4179 0.0e+00 lethal(2) giant larvae protein homolog 1 [Tribolium castaneum]>gi|642930673|ref|XP_008199983.1| PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X1 [Tribolium castaneum]>gi|270012677|gb|EFA09125.1| hypothetical protein TcasGA2_TC015986 [Tribolium castaneum]>gi|625293659|gb|AHY24027.1| lethal giant larvae [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 Q08470 2035 1.8e-226 Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura GN=l(2)gl PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.50229 BP_3 30.61 0.78 2194 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.50231 BP_3 238.99 1.98 6113 734625955 XP_010741096.1 446 7.6e-41 PREDICTED: uncharacterized protein LOC104928499 [Larimichthys crocea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8IYB9 395 2.6e-36 Zinc finger protein 595 OS=Homo sapiens GN=ZNF595 PE=2 SV=1 PF00096//PF13465//PF13912//PF06305 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Protein of unknown function (DUF1049) -- -- GO:0046872 metal ion binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.50232 BP_3 78.14 1.65 2578 91082913 XP_972525.1 874 7.5e-91 PREDICTED: sorting nexin-20 [Tribolium castaneum]>gi|270007065|gb|EFA03513.1| hypothetical protein TcasGA2_TC013515 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 549 1.5e-54 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF00787//PF10503 PX domain//Esterase PHB depolymerase -- -- GO:0035091 phosphatidylinositol binding GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.50233 BP_3 178.97 1.88 4887 642914939 XP_008190450.1 1788 1.5e-196 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K13983 MOV10L1 putative helicase MOV10L1 http://www.genome.jp/dbget-bin/www_bget?ko:K13983 Q1LXK4 952 5.3e-101 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF02562//PF01637//PF04851//PF00176//PF00580//PF05970//PF13361//PF00270//PF00437//PF00004 PhoH-like protein//Archaeal ATPase//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//UvrD/REP helicase N-terminal domain//PIF1-like helicase//UvrD-like helicase C-terminal domain//DEAD/DEAH box helicase//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0000723//GO:0006810//GO:0006281 telomere maintenance//transport//DNA repair GO:0003676//GO:0016787//GO:0003677//GO:0003678//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//DNA helicase activity//ATP binding GO:0005657 replication fork KOG1804 RNA helicase Cluster-8309.50236 BP_3 140.73 2.89 2641 270006959 EFA03407.1 1289 5.8e-139 hypothetical protein TcasGA2_TC013394 [Tribolium castaneum] -- -- -- -- -- K11248 SH3GLB endophilin-B http://www.genome.jp/dbget-bin/www_bget?ko:K11248 Q5ZIR1 753 3.4e-78 Endophilin-B1 OS=Gallus gallus GN=SH3GLB1 PE=2 SV=1 PF00018//PF14604//PF03114 SH3 domain//Variant SH3 domain//BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG3725 SH3 domain protein SH3GLB Cluster-8309.50241 BP_3 246.95 5.37 2509 91085733 XP_973505.1 2855 0.0e+00 PREDICTED: tRNA (cytosine(34)-C(5))-methyltransferase [Tribolium castaneum] -- -- -- -- -- K15335 NSUN2 tRNA (cytosine34-C5)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15335 Q9W4M9 1723 1.1e-190 tRNA (cytosine(34)-C(5))-methyltransferase OS=Drosophila melanogaster GN=Nsun2 PE=2 SV=1 PF01728//PF01189 FtsJ-like methyltransferase//16S rRNA methyltransferase RsmF GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2198 tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily Cluster-8309.50245 BP_3 1050.56 14.74 3728 270009986 EFA06434.1 1611 3.8e-176 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.7e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF03359//PF01544//PF02653 Guanylate-kinase-associated protein (GKAP) protein//CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component GO:0055085//GO:0023052//GO:0030001//GO:0006810 transmembrane transport//signaling//metal ion transport//transport GO:0046873//GO:0005215 metal ion transmembrane transporter activity//transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.50247 BP_3 36.00 7.34 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50248 BP_3 138.79 2.23 3298 642911164 XP_008200608.1 2198 2.9e-244 PREDICTED: sodium/hydrogen exchanger 7 isoform X1 [Tribolium castaneum] 556959399 XM_005990356.1 38 1.12325e-07 PREDICTED: Latimeria chalumnae solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant X3, mRNA K12041 SLC9A6_7, NHE6_7 solute carrier family 9 (sodium/hydrogen exchanger), member 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K12041 Q8BLV3 1283 1.5e-139 Sodium/hydrogen exchanger 7 OS=Mus musculus GN=Slc9a7 PE=2 SV=1 PF00999//PF11522 Sodium/hydrogen exchanger family//Yeast phosphatidylinositol-4-OH kinase Pik1 GO:0055085//GO:0006885//GO:0006812 transmembrane transport//regulation of pH//cation transport GO:0015299//GO:0016773 solute:proton antiporter activity//phosphotransferase activity, alcohol group as acceptor GO:0016021 integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.50250 BP_3 773.48 12.68 3232 642918695 XP_008191541.1 1571 1.4e-171 PREDICTED: protein sprint isoform X3 [Tribolium castaneum]>gi|642918697|ref|XP_008191542.1| PREDICTED: protein sprint isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 643 2.4e-65 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.50254 BP_3 593.89 8.44 3685 642926212 XP_008194831.1 2213 5.9e-246 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926214|ref|XP_008194832.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926216|ref|XP_973431.2| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926218|ref|XP_008194833.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926220|ref|XP_008194834.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926222|ref|XP_008194835.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] 749752848 XM_011140486.1 61 2.05843e-20 PREDICTED: Harpegnathos saltator putative fatty acyl-CoA reductase CG5065 (LOC105182795), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1491 1.3e-163 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01073//PF01118//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0055114//GO:0006694//GO:0008209//GO:0008207//GO:0008210 oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0080019//GO:0051287//GO:0016616//GO:0003854//GO:0050662//GO:0003824 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.50255 BP_3 405.49 6.79 3172 189235122 XP_001811652.1 2006 5.1e-222 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 422 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1600 2.5e-176 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF04277//PF00856//PF01496//PF15048 Oxaloacetate decarboxylase, gamma chain//SET domain//V-type ATPase 116kDa subunit family//Organic solute transporter subunit beta protein GO:0015991//GO:0006560//GO:0006814//GO:0006090//GO:0071436//GO:0015992//GO:0006525//GO:0015721//GO:0006810 ATP hydrolysis coupled proton transport//proline metabolic process//sodium ion transport//pyruvate metabolic process//sodium ion export//proton transport//arginine metabolic process//bile acid and bile salt transport//transport GO:0015081//GO:0005215//GO:0046982//GO:0005515//GO:0015078//GO:0003682//GO:0008948 sodium ion transmembrane transporter activity//transporter activity//protein heterodimerization activity//protein binding//hydrogen ion transmembrane transporter activity//chromatin binding//oxaloacetate decarboxylase activity GO:0016020//GO:0033179//GO:0000785//GO:0005886 membrane//proton-transporting V-type ATPase, V0 domain//chromatin//plasma membrane KOG1079 Transcriptional repressor EZH1 Cluster-8309.50256 BP_3 134.76 1.47 4724 91083631 XP_970382.1 4149 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.87796e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 P11024 3168 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Bos taurus GN=NNT PE=1 SV=3 PF00236//PF07074//PF00107//PF02456//PF02233//PF00005//PF01752//PF02826//PF03188//PF00205 Glycoprotein hormone//Translocon-associated protein, gamma subunit (TRAP-gamma)//Zinc-binding dehydrogenase//Adenovirus IVa2 protein//NAD(P) transhydrogenase beta subunit//ABC transporter//Collagenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Thiamine pyrophosphate enzyme, central domain GO:0006508//GO:0019083//GO:0007165//GO:0006613//GO:0046497//GO:0015992//GO:0006769//GO:0055114 proteolysis//viral transcription//signal transduction//cotranslational protein targeting to membrane//nicotinate nucleotide metabolic process//proton transport//nicotinamide metabolic process//oxidation-reduction process GO:0050661//GO:0051287//GO:0005179//GO:0030976//GO:0000287//GO:0005524//GO:0008750//GO:0016887//GO:0008270//GO:0004252 NADP binding//NAD binding//hormone activity//thiamine pyrophosphate binding//magnesium ion binding//ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//ATPase activity//zinc ion binding//serine-type endopeptidase activity GO:0030176//GO:0005784//GO:0005576//GO:0016021 integral component of endoplasmic reticulum membrane//Sec61 translocon complex//extracellular region//integral component of membrane -- -- Cluster-8309.50257 BP_3 463.60 10.76 2369 642915430 XP_008190612.1 1893 4.8e-209 PREDICTED: WD repeat-containing protein 75 [Tribolium castaneum]>gi|270004005|gb|EFA00453.1| hypothetical protein TcasGA2_TC003309 [Tribolium castaneum] -- -- -- -- -- K14552 NAN1, UTP17, WDR75 NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) http://www.genome.jp/dbget-bin/www_bget?ko:K14552 Q6DFC6 757 1.1e-78 WD repeat-containing protein 75 OS=Xenopus laevis GN=wdr75 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1963 WD40 repeat protein Cluster-8309.50263 BP_3 1119.89 29.30 2134 642924770 XP_008194433.1 2238 4.3e-249 PREDICTED: netrin receptor UNC5C isoform X1 [Tribolium castaneum] -- -- -- -- -- K07521 UNC5 netrin receptor unc-5 http://www.genome.jp/dbget-bin/www_bget?ko:K07521 Q95TU8 714 9.2e-74 Netrin receptor unc-5 OS=Drosophila melanogaster GN=unc-5 PE=1 SV=1 PF11468//PF13895//PF01733//PF01632 Aromatic prenyltransferase Orf2//Immunoglobulin domain//Nucleoside transporter//Ribosomal protein L35 GO:0006810//GO:0006412//GO:0015858//GO:0042254 transport//translation//nucleoside transport//ribosome biogenesis GO:0005515//GO:0016740//GO:0005337//GO:0003735 protein binding//transferase activity//nucleoside transmembrane transporter activity//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622 integral component of membrane//ribosome//intracellular KOG1480 Netrin transmembrane receptor unc-5 Cluster-8309.50264 BP_3 208.78 22.01 749 478255161 ENN75390.1 547 1.8e-53 hypothetical protein YQE_07942, partial [Dendroctonus ponderosae] -- -- -- -- -- K15262 BCP1, BCCIP protein BCP1 http://www.genome.jp/dbget-bin/www_bget?ko:K15262 Q9VFR0 360 3.6e-33 Protein BCCIP homolog OS=Drosophila melanogaster GN=CG9286 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3034 Isoamyl acetate-hydrolyzing esterase and related enzymes Cluster-8309.50265 BP_3 163.83 0.62 13067 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 800 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.3e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF06743//PF01436//PF01017//PF03124//PF14634//PF00643//PF00097 FAST kinase-like protein, subdomain 1//NHL repeat//STAT protein, all-alpha domain//EXS family//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0008270//GO:0004871//GO:0003700//GO:0046872//GO:0004672//GO:0005515 zinc ion binding//signal transducer activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//protein kinase activity//protein binding GO:0005622//GO:0016021//GO:0005667 intracellular//integral component of membrane//transcription factor complex KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.50266 BP_3 449.67 1.69 13121 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 798 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.3e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF14634//PF00643//PF00097//PF06743//PF01436//PF03124//PF01017 zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger)//FAST kinase-like protein, subdomain 1//NHL repeat//EXS family//STAT protein, all-alpha domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0046872//GO:0004672//GO:0003700//GO:0004871//GO:0008270//GO:0005515 metal ion binding//protein kinase activity//transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding//protein binding GO:0005622//GO:0005667//GO:0016021 intracellular//transcription factor complex//integral component of membrane KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.50267 BP_3 32.37 0.32 5137 769848297 XP_011635512.1 1496 1.1e-162 PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus]>gi|769848299|ref|XP_011635513.1| PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus] 572314861 XM_006623032.1 428 0 PREDICTED: Apis dorsata developmentally-regulated GTP-binding protein 2-like (LOC102680357), transcript variant X1, mRNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 1333 3.7e-145 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF01926//PF05875//PF00176//PF03193//PF03006//PF02421 50S ribosome-binding GTPase//Ceramidase//SNF2 family N-terminal domain//Protein of unknown function, DUF258//Haemolysin-III related//Ferrous iron transport protein B GO:0006672//GO:0006807//GO:0015684 ceramide metabolic process//nitrogen compound metabolic process//ferrous iron transport GO:0005524//GO:0015093//GO:0016811//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//GTPase activity//GTP binding GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.50268 BP_3 35.53 0.34 5340 769848297 XP_011635512.1 1496 1.2e-162 PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus]>gi|769848299|ref|XP_011635513.1| PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus] 572314861 XM_006623032.1 428 0 PREDICTED: Apis dorsata developmentally-regulated GTP-binding protein 2-like (LOC102680357), transcript variant X1, mRNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 1333 3.8e-145 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF03006//PF02421//PF01926//PF03193//PF00176 Haemolysin-III related//Ferrous iron transport protein B//50S ribosome-binding GTPase//Protein of unknown function, DUF258//SNF2 family N-terminal domain GO:0015684 ferrous iron transport GO:0003924//GO:0005524//GO:0005525//GO:0015093 GTPase activity//ATP binding//GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.50269 BP_3 80.53 4.07 1245 642913824 XP_008201175.1 211 2.8e-14 PREDICTED: microtubule-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05296 Taste receptor protein (TAS2R) GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50271 BP_3 14.63 0.36 2265 780665970 XP_011694053.1 813 7.9e-84 PREDICTED: uncharacterized protein LOC105453629 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02465//PF15233//PF03462//PF01496//PF09668//PF04111//PF02050//PF07544//PF17082//PF04136//PF02185//PF11427 Flagellar hook-associated protein 2 N-terminus//Synaptonemal complex central element protein 1//PCRF domain//V-type ATPase 116kDa subunit family//Aspartyl protease//Autophagy protein Apg6//Flagellar FliJ protein//RNA polymerase II transcription mediator complex subunit 9//Spindle Pole Component 29//Sec34-like family//Hr1 repeat//Tc3 transposase GO:0007130//GO:0070193//GO:0015991//GO:0006449//GO:0006914//GO:0007128//GO:0006886//GO:0007165//GO:0006508//GO:0030474//GO:0071973//GO:0006935//GO:0015992//GO:0006357//GO:0006415 synaptonemal complex assembly//synaptonemal complex organization//ATP hydrolysis coupled proton transport//regulation of translational termination//autophagy//meiotic prophase I//intracellular protein transport//signal transduction//proteolysis//spindle pole body duplication//bacterial-type flagellum-dependent cell motility//chemotaxis//proton transport//regulation of transcription from RNA polymerase II promoter//translational termination GO:0016149//GO:0003677//GO:0015078//GO:0003774//GO:0001104//GO:0004190//GO:0005200 translation release factor activity, codon specific//DNA binding//hydrogen ion transmembrane transporter activity//motor activity//RNA polymerase II transcription cofactor activity//aspartic-type endopeptidase activity//structural constituent of cytoskeleton GO:0033179//GO:0016020//GO:0000795//GO:0005856//GO:0005737//GO:0005823//GO:0005840//GO:0005801//GO:0009424//GO:0016592//GO:0018444//GO:0009288 proton-transporting V-type ATPase, V0 domain//membrane//synaptonemal complex//cytoskeleton//cytoplasm//central plaque of spindle pole body//ribosome//cis-Golgi network//bacterial-type flagellum hook//mediator complex//translation release factor complex//bacterial-type flagellum -- -- Cluster-8309.50272 BP_3 1.96 1.49 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50274 BP_3 92.71 1.79 2792 642919713 XP_008192033.1 1789 6.5e-197 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.5e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.50275 BP_3 46.55 0.40 5943 102939 1614 2.7e-176 hypothetical protein 2 - cabbage looper transposon TED (fragment) 667676433 AE013599.5 36 2.63119e-06 Drosophila melanogaster chromosome 2R -- -- -- -- P04323 1273 3.9e-138 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.50276 BP_3 13.45 0.61 1355 642928838 XP_008195583.1 1291 1.8e-139 PREDICTED: uncharacterized protein LOC656400 [Tribolium castaneum] 642928837 XM_008197361.1 282 1.04436e-143 PREDICTED: Tribolium castaneum uncharacterized LOC656400 (LOC656400), mRNA -- -- -- -- -- -- -- -- PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.50279 BP_3 415.67 7.63 2918 189238125 XP_001814215.1 3173 0.0e+00 PREDICTED: phagocyte signaling-impaired protein [Tribolium castaneum]>gi|270008817|gb|EFA05265.1| hypothetical protein TcasGA2_TC015420 [Tribolium castaneum] 462295253 APGK01052815.1 38 9.92396e-08 Dendroctonus ponderosae Seq01052825, whole genome shotgun sequence K17973 NAA25, MDM20 N-terminal acetyltransferase B complex non-catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17973 Q9VDQ7 1583 2.2e-174 Phagocyte signaling-impaired protein OS=Drosophila melanogaster GN=psidin PE=2 SV=1 PF14863//PF13414 Alkyl sulfatase dimerisation//TPR repeat -- -- GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG2053 Mitochondrial inheritance and actin cytoskeleton organization protein Cluster-8309.5028 BP_3 6.53 1.02 601 642927459 XP_968905.2 228 1.4e-16 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q28719 158 7.7e-10 Prostaglandin reductase 1 OS=Oryctolagus cuniculus GN=PTGR1 PE=2 SV=1 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.50282 BP_3 21.55 0.65 1896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845 Spore germination protein GO:0009847 spore germination -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50283 BP_3 75.12 4.77 1051 189236433 XP_972706.2 827 8.7e-86 PREDICTED: nuclear transcription factor Y subunit alpha isoform X1 [Tribolium castaneum]>gi|270005402|gb|EFA01850.1| hypothetical protein TcasGA2_TC007453 [Tribolium castaneum] 642919803 XM_967613.3 141 1.93731e-65 PREDICTED: Tribolium castaneum nuclear transcription factor Y subunit alpha (LOC661458), transcript variant X1, mRNA K08064 NFYA nuclear transcription factor Y, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08064 P23511 325 5.8e-29 Nuclear transcription factor Y subunit alpha OS=Homo sapiens GN=NFYA PE=1 SV=2 PF11525//PF02045//PF00737//PF09606 Copper resistance protein K//CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B//Photosystem II 10 kDa phosphoprotein//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006355//GO:0006357//GO:0050821//GO:0015979 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//protein stabilization//photosynthesis GO:0046872//GO:0003700//GO:0042301//GO:0001104 metal ion binding//transcription factor activity, sequence-specific DNA binding//phosphate ion binding//RNA polymerase II transcription cofactor activity GO:0009523//GO:0016020//GO:0005667//GO:0016592 photosystem II//membrane//transcription factor complex//mediator complex KOG1561 CCAAT-binding factor, subunit B (HAP2) Cluster-8309.50289 BP_3 40.13 2.88 963 642916451 XP_008191033.1 241 7.1e-18 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5029 BP_3 4.00 0.91 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50292 BP_3 902.90 9.72 4770 332377021 AEE63650.1 2446 7.3e-273 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01303 APEH acylaminoacyl-peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01303 P13676 1008 1.7e-107 Acylamino-acid-releasing enzyme OS=Rattus norvegicus GN=Apeh PE=1 SV=1 PF00326//PF00769//PF07859//PF02129 Prolyl oligopeptidase family//Ezrin/radixin/moesin family//alpha/beta hydrolase fold//X-Pro dipeptidyl-peptidase (S15 family) GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008092//GO:0016787//GO:0008236 cytoskeletal protein binding//hydrolase activity//serine-type peptidase activity GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG2010 Double stranded RNA binding protein Cluster-8309.50295 BP_3 14.00 22.63 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50297 BP_3 344.31 5.26 3444 642927943 XP_008195456.1 771 8.9e-79 PREDICTED: tetratricopeptide repeat protein 37 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DFB8 283 1.4e-23 Tetratricopeptide repeat protein 37 OS=Xenopus laevis GN=ttc37 PE=2 SV=1 PF13414//PF13174//PF13176//PF16045//PF13374//PF00515//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//LisH//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50298 BP_3 207.00 33.78 587 546683525 ERL93327.1 440 3.6e-41 hypothetical protein D910_10621 [Dendroctonus ponderosae] 572257679 XM_006607174.1 44 8.80252e-12 PREDICTED: Apis dorsata PAXIP1-associated glutamate-rich protein 1-like (LOC102673490), mRNA K14973 PA1 PAXIP1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14973 Q9BTK6 134 4.5e-07 PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens GN=PAGR1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50299 BP_3 3.73 0.99 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50300 BP_3 90.12 2.62 1951 642940167 XP_008194639.1 623 7.3e-62 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXM1 253 2.4e-20 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens GN=LRIG3 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.50301 BP_3 53.78 0.90 3184 478258656 ENN78706.1 208 1.6e-13 hypothetical protein YQE_04878, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50302 BP_3 284.90 6.20 2506 642926809 XP_008195022.1 149 8.6e-07 PREDICTED: zinc finger protein 64 homolog, isoforms 3 and 4-like [Tribolium castaneum]>gi|270009173|gb|EFA05621.1| hypothetical protein TcasGA2_TC015829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF10588 Zinc-finger associated domain (zf-AD)//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114 oxidation-reduction process GO:0016491//GO:0008270 oxidoreductase activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.50303 BP_3 9704.44 108.80 4591 642924939 XP_008194106.1 1397 3.0e-151 PREDICTED: uncharacterized protein LOC100142197 isoform X2 [Tribolium castaneum] 642924938 XM_008195884.1 157 1.10597e-73 PREDICTED: Tribolium castaneum uncharacterized LOC100142197 (LOC100142197), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50305 BP_3 33.29 0.39 4434 642911033 XP_008193517.1 3553 0.0e+00 PREDICTED: small conductance calcium-activated potassium channel protein [Tribolium castaneum] 642911032 XM_008195295.1 849 0 PREDICTED: Tribolium castaneum small conductance calcium-activated potassium channel protein (LOC657962), mRNA K05325 KCNNN potassium intermediate/small conductance calcium-activated channel subfamily N, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05325 Q7KVW5 2115 6.7e-236 Small conductance calcium-activated potassium channel protein OS=Drosophila melanogaster GN=SK PE=2 SV=2 PF01544//PF02888//PF00520//PF03119//PF01407//PF03530 CorA-like Mg2+ transporter protein//Calmodulin binding domain//Ion transport protein//NAD-dependent DNA ligase C4 zinc finger domain//Geminivirus AL3 protein//Calcium-activated SK potassium channel GO:0006811//GO:0006260//GO:0006813//GO:0006281//GO:0030001//GO:0055085//GO:0016032 ion transport//DNA replication//potassium ion transport//DNA repair//metal ion transport//transmembrane transport//viral process GO:0005216//GO:0046873//GO:0016286//GO:0015269//GO:0005516//GO:0003911 ion channel activity//metal ion transmembrane transporter activity//small conductance calcium-activated potassium channel activity//calcium-activated potassium channel activity//calmodulin binding//DNA ligase (NAD+) activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3684 Ca2+-activated K+ channel proteins (intermediate/small conductance classes) Cluster-8309.50310 BP_3 8.00 0.44 1172 642933823 XP_008197408.1 189 9.2e-12 PREDICTED: formin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50315 BP_3 35.00 2.03 1122 861599125 KMQ83546.1 1141 3.6e-122 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- Q53H47 125 9.6e-06 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF00292//PF01498//PF09749//PF01047//PF02796//PF04218 'Paired box' domain//Transposase//Uncharacterised conserved protein//MarR family//Helix-turn-helix domain of resolvase//CENP-B N-terminal DNA-binding domain GO:0006313//GO:0015074//GO:0034477//GO:0006355//GO:0006310 transposition, DNA-mediated//DNA integration//U6 snRNA 3'-end processing//regulation of transcription, DNA-templated//DNA recombination GO:0000150//GO:0003677//GO:0003700//GO:0004518 recombinase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//nuclease activity GO:0005667 transcription factor complex -- -- Cluster-8309.50318 BP_3 114.51 1.34 4404 795018312 XP_011859165.1 573 1.0e-55 PREDICTED: uncharacterized protein LOC105556682 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50320 BP_3 150.04 2.05 3818 270004788 EFA01236.1 1095 2.6e-116 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1XG89 391 4.7e-36 Putative ATP-dependent RNA helicase TDRD12 OS=Bombyx mori GN=TDRD12 PE=1 SV=2 PF00270 DEAD/DEAH box helicase -- -- GO:0003676//GO:0005524 nucleic acid binding//ATP binding -- -- -- -- Cluster-8309.50321 BP_3 163.00 4.95 1879 270004788 EFA01236.1 980 2.8e-103 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1XG89 400 2.1e-37 Putative ATP-dependent RNA helicase TDRD12 OS=Bombyx mori GN=TDRD12 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50323 BP_3 156.96 2.11 3873 270004788 EFA01236.1 887 3.5e-92 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1XG89 287 5.4e-24 Putative ATP-dependent RNA helicase TDRD12 OS=Bombyx mori GN=TDRD12 PE=1 SV=2 PF00270 DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676 ATP binding//nucleic acid binding -- -- -- -- Cluster-8309.50324 BP_3 141.38 1.06 6737 270014943 EFA11391.1 6857 0.0e+00 hypothetical protein TcasGA2_TC011551 [Tribolium castaneum] 642910356 XM_008202069.1 422 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 2621 2.2e-294 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF00069//PF00433//PF07714//PF01291//PF08826//PF00130 Protein kinase domain//Protein kinase C terminal domain//Protein tyrosine kinase//LIF / OSM family//DMPK coiled coil domain like//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007165//GO:0006468//GO:0009069//GO:0016310//GO:0006955//GO:0035556 signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//immune response//intracellular signal transduction GO:0005524//GO:0005125//GO:0004672//GO:0004674 ATP binding//cytokine activity//protein kinase activity//protein serine/threonine kinase activity GO:0005576 extracellular region KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.50327 BP_3 433.34 2.14 10054 91076250 XP_966964.1 1806 2.5e-198 PREDICTED: testican-2 [Tribolium castaneum] 642912114 XM_961871.3 78 2.00316e-29 PREDICTED: Tribolium castaneum testican-2 (LOC655329), mRNA -- -- -- -- Q9ER58 343 4.5e-30 Testican-2 OS=Mus musculus GN=Spock2 PE=2 SV=1 PF07648//PF13833//PF00050//PF10591//PF00036//PF15009 Kazal-type serine protease inhibitor domain//EF-hand domain pair//Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//Transmembrane protein 173 GO:0032481//GO:0002218//GO:0007165 positive regulation of type I interferon production//activation of innate immune response//signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG3555 Ca2+-binding proteoglycan Testican Cluster-8309.50330 BP_3 327.84 7.85 2305 642918756 XP_008191570.1 1365 7.8e-148 PREDICTED: thymidylate synthase-like [Tribolium castaneum]>gi|270005647|gb|EFA02095.1| hypothetical protein TcasGA2_TC007732 [Tribolium castaneum] 674038954 XM_008826954.1 103 5.75244e-44 PREDICTED: Nannospalax galili thymidylate synthetase (Tyms), mRNA K00560 thyA, TYMS thymidylate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00560 P04818 1141 3.0e-123 Thymidylate synthase OS=Homo sapiens GN=TYMS PE=1 SV=3 PF02949//PF00303//PF06385 7tm Odorant receptor//Thymidylate synthase//Baculovirus LEF-11 protein GO:0019058//GO:0006231//GO:0007187//GO:0032259//GO:0006206//GO:0007608//GO:0006235//GO:0006355 viral life cycle//dTMP biosynthetic process//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//methylation//pyrimidine nucleobase metabolic process//sensory perception of smell//dTTP biosynthetic process//regulation of transcription, DNA-templated GO:0005549//GO:0004984//GO:0004799 odorant binding//olfactory receptor activity//thymidylate synthase activity GO:0016020 membrane KOG0673 Thymidylate synthase Cluster-8309.50331 BP_3 171.50 1.71 5115 642931709 XP_008196696.1 3580 0.0e+00 PREDICTED: golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [Tribolium castaneum]>gi|270011755|gb|EFA08203.1| hypothetical protein TcasGA2_TC005830 [Tribolium castaneum] 642931708 XM_008198474.1 214 2.54044e-105 PREDICTED: Tribolium castaneum golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (LOC655455), mRNA K18443 GBF1 golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18443 Q92538 1421 2.3e-155 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens GN=GBF1 PE=1 SV=2 PF01369//PF00001 Sec7 domain//7 transmembrane receptor (rhodopsin family) GO:0043087//GO:0032012//GO:0007186 regulation of GTPase activity//regulation of ARF protein signal transduction//G-protein coupled receptor signaling pathway GO:0004930//GO:0005086 G-protein coupled receptor activity//ARF guanyl-nucleotide exchange factor activity GO:0016021 integral component of membrane KOG0928 Pattern-formation protein/guanine nucleotide exchange factor Cluster-8309.50333 BP_3 448.53 3.33 6793 91077932 XP_974190.1 2842 0.0e+00 PREDICTED: conserved oligomeric Golgi complex subunit 7 [Tribolium castaneum] 820862785 XM_003697932.2 121 1.68694e-53 PREDICTED: Apis florea U4/U6 small nuclear ribonucleoprotein Prp4 (LOC100870360), mRNA K12662 PRPF4, PRP4 U4/U6 small nuclear ribonucleoprotein PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K12662 Q3MHE2 1614 1.3e-177 U4/U6 small nuclear ribonucleoprotein Prp4 OS=Bos taurus GN=PRPF4 PE=2 SV=1 PF10191//PF10392//PF02468//PF00400 Golgi complex component 7 (COG7)//Golgi transport complex subunit 5//Photosystem II reaction centre N protein (psbN)//WD domain, G-beta repeat GO:0006886//GO:0006891//GO:0015979 intracellular protein transport//intra-Golgi vesicle-mediated transport//photosynthesis GO:0005515 protein binding GO:0009523//GO:0009539//GO:0017119//GO:0016020 photosystem II//photosystem II reaction center//Golgi transport complex//membrane KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats) Cluster-8309.50335 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01483 Proprotein convertase P-domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.50338 BP_3 168.83 1.53 5613 642928360 XP_972133.2 2245 1.7e-249 PREDICTED: ATP-binding cassette sub-family B member 8, mitochondrial isoform X1 [Tribolium castaneum] 768408887 XM_011551471.1 79 3.10182e-30 PREDICTED: Plutella xylostella igLON family member 5-like (LOC105381682), mRNA K05655 ABCB8 ATP-binding cassette, subfamily B (MDR/TAP), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K05655 B2GUP8 1544 1.4e-169 ATP-binding cassette sub-family B member 8, mitochondrial OS=Xenopus tropicalis GN=abcb8 PE=2 SV=1 PF06472//PF12814//PF01583//PF13304//PF00664//PF13895//PF03193//PF00005//PF06414 ABC transporter transmembrane region 2//Meiotic cell cortex C-terminal pleckstrin homology//Adenylylsulphate kinase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Immunoglobulin domain//Protein of unknown function, DUF258//ABC transporter//Zeta toxin GO:0006810//GO:0055085//GO:0006144//GO:0000103//GO:0032065 transport//transmembrane transport//purine nucleobase metabolic process//sulfate assimilation//cortical protein anchoring GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0016301//GO:0005543//GO:0004020//GO:0005515//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//phospholipid binding//adenylylsulfate kinase activity//protein binding//GTP binding GO:0016021//GO:0005938 integral component of membrane//cell cortex KOG0058 Peptide exporter, ABC superfamily Cluster-8309.50339 BP_3 653.03 4.11 7953 751224154 XP_011165403.1 884 1.6e-91 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07180//PF01825 Protein of unknown function (DUF1401)//GPCR proteolysis site, GPS, motif GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.5034 BP_3 4.00 0.47 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50340 BP_3 1699.39 11.35 7510 751224154 XP_011165403.1 1440 5.1e-156 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF07180 GPCR proteolysis site, GPS, motif//Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.50341 BP_3 302.86 1.86 8155 751224154 XP_011165403.1 1304 3.3e-140 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF07180 GPCR proteolysis site, GPS, motif//Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.50342 BP_3 135.56 0.86 7846 751224154 XP_011165403.1 1312 3.7e-141 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF07180 GPCR proteolysis site, GPS, motif//Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.50343 BP_3 1914.53 33.43 3052 815766413 XP_012219810.1 1004 7.5e-106 PREDICTED: uncharacterized protein LOC105670709 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06350//PF11435 Hormone-sensitive lipase (HSL) N-terminus//RNA binding protein She2p GO:0016042//GO:0008203 lipid catabolic process//cholesterol metabolic process GO:0016298//GO:0003723 lipase activity//RNA binding -- -- -- -- Cluster-8309.50344 BP_3 601.00 21.86 1617 642933692 XP_008197523.1 1004 4.0e-106 PREDICTED: ankyrin repeat domain-containing protein 6 [Tribolium castaneum]>gi|270012614|gb|EFA09062.1| hypothetical protein TcasGA2_TC006777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2G4 484 3.3e-47 Ankyrin repeat domain-containing protein 6 OS=Homo sapiens GN=ANKRD6 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50345 BP_3 273.00 12.42 1351 61652776 AAX47960.1 737 3.0e-75 prophenoloxidase activating factor serine proteinase [Scylla serrata] 61652775 AY946200.1 252 4.9481e-127 Scylla serrata prophenoloxidase activating factor serine proteinase (PPAF-SP) mRNA, complete cds -- -- -- -- Q7RTY7 459 2.2e-44 Ovochymase-1 OS=Homo sapiens GN=OVCH1 PE=2 SV=2 PF00089//PF16622 Trypsin//zinc-finger C2H2-type GO:0006508 proteolysis GO:0004252//GO:0046872 serine-type endopeptidase activity//metal ion binding -- -- -- -- Cluster-8309.50346 BP_3 11.00 1.30 699 -- -- -- -- -- 333103092 JF715397.1 177 1.23143e-85 Scylla paramamosain clone SP13 microsatellite sequence -- -- -- -- -- -- -- -- PF05434//PF12409 TMEM9//P5-type ATPase cation transporter GO:0006812 cation transport GO:0016887 ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50347 BP_3 19.00 0.46 2284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50352 BP_3 296.57 4.62 3386 478254798 ENN75034.1 2058 5.1e-228 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 227 9.94294e-113 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 1138 1.0e-122 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF00887//PF00403 Acyl CoA binding protein//Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872//GO:0000062 metal ion binding//fatty-acyl-CoA binding -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.50353 BP_3 92.00 2.83 1858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50354 BP_3 36.86 0.79 2534 607361054 EZA55356.1 530 5.7e-51 Putative nuclease HARBI1, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- Q6AZB8 284 7.9e-24 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF03213//PF01609 Poxvirus P35 protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding GO:0019031 viral envelope -- -- Cluster-8309.50357 BP_3 249.22 1.47 8446 270015299 EFA11747.1 1770 3.1e-194 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2VWP9 589 1.1e-58 Protogenin OS=Rattus norvegicus GN=Prtg PE=2 SV=1 PF00041//PF13895//PF16656 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.50364 BP_3 35.41 0.39 4665 91078420 XP_974692.1 1419 8.7e-154 PREDICTED: tektin-3 [Tribolium castaneum]>gi|270003874|gb|EFA00322.1| hypothetical protein TcasGA2_TC003160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16T79 1220 4.3e-132 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Aedes aegypti GN=AAEL010360 PE=3 SV=2 PF08912//PF08702//PF00005//PF03193//PF07989//PF03938//PF00437//PF01920//PF01544//PF01583//PF16331//PF00931//PF09177//PF06414//PF03082//PF02951//PF16716//PF07728 Rho Binding//Fibrinogen alpha/beta chain family//ABC transporter//Protein of unknown function, DUF258//Centrosomin N-terminal motif 1//Outer membrane protein (OmpH-like)//Type II/IV secretion system protein//Prefoldin subunit//CorA-like Mg2+ transporter protein//Adenylylsulphate kinase//TolA binding protein trimerisation//NB-ARC domain//Syntaxin 6, N-terminal//Zeta toxin//Male accessory gland secretory protein//Prokaryotic glutathione synthetase, N-terminal domain//Bone marrow stromal antigen 2//AAA domain (dynein-related subfamily) GO:0030168//GO:0000103//GO:0048193//GO:0006750//GO:0055085//GO:0000226//GO:0007618//GO:0006144//GO:0051607//GO:0030001//GO:0006457//GO:0051258//GO:0070206//GO:0006810//GO:0007165 platelet activation//sulfate assimilation//Golgi vesicle transport//glutathione biosynthetic process//transmembrane transport//microtubule cytoskeleton organization//mating//purine nucleobase metabolic process//defense response to virus//metal ion transport//protein folding//protein polymerization//protein trimerization//transport//signal transduction GO:0017048//GO:0030674//GO:0046873//GO:0051082//GO:0016887//GO:0005102//GO:0016301//GO:0003924//GO:0005524//GO:0005525//GO:0043531//GO:0004020//GO:0004363 Rho GTPase binding//protein binding, bridging//metal ion transmembrane transporter activity//unfolded protein binding//ATPase activity//receptor binding//kinase activity//GTPase activity//ATP binding//GTP binding//ADP binding//adenylylsulfate kinase activity//glutathione synthase activity GO:0005577//GO:0016272//GO:0005576//GO:0016020//GO:0005874//GO:0005815 fibrinogen complex//prefoldin complex//extracellular region//membrane//microtubule//microtubule organizing center KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.50365 BP_3 38.29 0.66 3106 642917011 XP_008199595.1 2473 3.5e-276 PREDICTED: probable ATP-dependent RNA helicase DHX35 [Tribolium castaneum] -- -- -- -- -- K13117 DHX35 ATP-dependent RNA helicase DDX35 http://www.genome.jp/dbget-bin/www_bget?ko:K13117 Q9H5Z1 1549 2.0e-170 Probable ATP-dependent RNA helicase DHX35 OS=Homo sapiens GN=DHX35 PE=1 SV=2 PF00400//PF04408//PF01436 WD domain, G-beta repeat//Helicase associated domain (HA2)//NHL repeat -- -- GO:0004386//GO:0005515 helicase activity//protein binding -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.50367 BP_3 27.21 0.53 2750 546684608 ERL94225.1 1767 2.3e-194 hypothetical protein D910_11506 [Dendroctonus ponderosae] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q640H3 747 1.8e-77 OTU domain-containing protein 5-B OS=Xenopus laevis GN=otud5-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.50374 BP_3 30.00 4.25 632 478252081 ENN72512.1 224 4.3e-16 hypothetical protein YQE_10853, partial [Dendroctonus ponderosae]>gi|546685597|gb|ERL95084.1| hypothetical protein D910_12354, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12106 Colicin C terminal ribonuclease domain GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity -- -- -- -- Cluster-8309.50375 BP_3 39.00 1.31 1722 91084303 XP_971911.1 1275 1.6e-137 PREDICTED: T-box transcription factor TBX1-A [Tribolium castaneum]>gi|270009267|gb|EFA05715.1| optomotor blind related gene 1 protein [Tribolium castaneum] 884973126 XM_010885314.2 48 1.60425e-13 PREDICTED: Esox lucius T-box 20 (tbx20), transcript variant X4, mRNA K10175 TBX1 T-box protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10175 Q8AX98 849 1.6e-89 T-box transcription factor TBX1-A OS=Xenopus laevis GN=tbx1-a PE=1 SV=1 PF00907 T-box GO:0006355//GO:0006351 regulation of transcription, DNA-templated//transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.50376 BP_3 313.93 3.21 5000 91085385 XP_966386.1 455 5.6e-42 PREDICTED: arginine/serine-rich coiled-coil protein 2 [Tribolium castaneum]>gi|270009149|gb|EFA05597.1| hypothetical protein TcasGA2_TC015801 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHJ5 200 8.6e-14 Arginine/serine-rich coiled-coil protein 2 OS=Xenopus tropicalis GN=rsrc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50377 BP_3 36.17 0.36 5125 91086901 XP_970921.1 1465 4.4e-159 PREDICTED: origin recognition complex subunit 4 [Tribolium castaneum]>gi|270010481|gb|EFA06929.1| hypothetical protein TcasGA2_TC009879 [Tribolium castaneum] -- -- -- -- -- K02606 ORC4 origin recognition complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02606 O43929 850 3.7e-89 Origin recognition complex subunit 4 OS=Homo sapiens GN=ORC4 PE=1 SV=2 PF01637//PF00005//PF13676//PF03193//PF03266//PF00448//PF00437//PF04517//PF05496//PF00578//PF03205//PF02367//PF00580//PF00004//PF00085//PF07728 Archaeal ATPase//ABC transporter//TIR domain//Protein of unknown function, DUF258//NTPase//SRP54-type protein, GTPase domain//Type II/IV secretion system protein//Microvirus lysis protein (E), C terminus//Holliday junction DNA helicase ruvB N-terminus//AhpC/TSA family//Molybdopterin guanine dinucleotide synthesis protein B//Threonylcarbamoyl adenosine biosynthesis protein TsaE//UvrD/REP helicase N-terminal domain//ATPase family associated with various cellular activities (AAA)//Thioredoxin//AAA domain (dynein-related subfamily) GO:0045454//GO:0006310//GO:0019054//GO:0002949//GO:0055114//GO:0006777//GO:0006260//GO:0006281//GO:0006810//GO:0006614//GO:0007165 cell redox homeostasis//DNA recombination//modulation by virus of host process//tRNA threonylcarbamoyladenosine modification//oxidation-reduction process//Mo-molybdopterin cofactor biosynthetic process//DNA replication//DNA repair//transport//SRP-dependent cotranslational protein targeting to membrane//signal transduction GO:0009378//GO:0005525//GO:0016491//GO:0005515//GO:0004857//GO:0003677//GO:0016887//GO:0016209//GO:0003924//GO:0098519//GO:0005524 four-way junction helicase activity//GTP binding//oxidoreductase activity//protein binding//enzyme inhibitor activity//DNA binding//ATPase activity//antioxidant activity//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding GO:0005634//GO:0005657//GO:0000808//GO:0009379 nucleus//replication fork//origin recognition complex//Holliday junction helicase complex KOG2228 Origin recognition complex, subunit 4 Cluster-8309.50379 BP_3 55.26 0.33 8465 270015299 EFA11747.1 1763 2.0e-193 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2VWP9 594 3.0e-59 Protogenin OS=Rattus norvegicus GN=Prtg PE=2 SV=1 PF16656//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.50380 BP_3 179.42 2.37 3946 270002078 EEZ98525.1 246 7.7e-18 hypothetical protein TcasGA2_TC001029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50384 BP_3 145.69 1.68 4475 478255961 ENN76162.1 1692 1.8e-185 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 Q8WY07 1081 5.4e-116 Cationic amino acid transporter 3 OS=Homo sapiens GN=SLC7A3 PE=1 SV=1 PF13520//PF15020//PF00324 Amino acid permease//Cation channel sperm-associated protein subunit delta//Amino acid permease GO:0006865//GO:0003333//GO:0055085//GO:0006810 amino acid transport//amino acid transmembrane transport//transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0036128//GO:0016020 CatSper complex//membrane -- -- Cluster-8309.50385 BP_3 19.15 1.30 1001 642918845 XP_008191611.1 332 2.1e-28 PREDICTED: phosphoglycolate phosphatase 2-like [Tribolium castaneum]>gi|270005689|gb|EFA02137.1| hypothetical protein TcasGA2_TC007787 [Tribolium castaneum] -- -- -- -- -- K01101 E3.1.3.41 4-nitrophenyl phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01101 -- -- -- -- -- -- GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.50386 BP_3 36.34 2.24 1075 642920711 XP_008192531.1 633 2.8e-63 PREDICTED: uncharacterized protein LOC103312793 isoform X1 [Tribolium castaneum]>gi|270006095|gb|EFA02543.1| hypothetical protein TcasGA2_TC008248 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50389 BP_3 965.11 8.18 5978 642920612 XP_008192488.1 1042 5.8e-110 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- -- -- Cluster-8309.50392 BP_3 310.29 15.15 1279 91082137 XP_966595.1 1464 1.4e-159 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 172 1.38598e-82 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1193 1.6e-129 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.50394 BP_3 106.45 3.06 1970 332373656 AEE61969.1 1637 1.9e-179 unknown [Dendroctonus ponderosae] 571430507 KF255600.1 387 0 Plutella xylostella protein phosphatase 4 mRNA, complete cds K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 A9JRC7 1586 6.5e-175 Serine/threonine-protein phosphatase 4 catalytic subunit B OS=Danio rerio GN=ppp4cb PE=2 SV=1 PF00149//PF01429 Calcineurin-like phosphoesterase//Methyl-CpG binding domain -- -- GO:0016787//GO:0003677 hydrolase activity//DNA binding GO:0005634 nucleus KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-8309.50395 BP_3 59.20 0.66 4608 642918982 XP_008191684.1 4714 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.436e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.50396 BP_3 1076.33 5.09 10489 642918082 XP_008193932.1 1793 8.4e-197 PREDICTED: protein disulfide-isomerase TMX3 [Tribolium castaneum] 795019206 XM_012004108.1 296 1.36347e-150 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556990 (LOC105556990), mRNA K09585 TXNDC10 thioredoxin domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09585 Q9VPF8 987 1.0e-104 Transmembrane protein 104 homolog OS=Drosophila melanogaster GN=CG5262 PE=2 SV=2 PF00085//PF00400//PF01428//PF01984//PF03222//PF00659//PF01216//PF02073//PF00578 Thioredoxin//WD domain, G-beta repeat//AN1-like Zinc finger//Double-stranded DNA-binding domain//Tryptophan/tyrosine permease family//POLO box duplicated region//Calsequestrin//Thermophilic metalloprotease (M29)//AhpC/TSA family GO:0045454//GO:0055114//GO:0006508//GO:0003333 cell redox homeostasis//oxidation-reduction process//proteolysis//amino acid transmembrane transport GO:0005515//GO:0016491//GO:0003677//GO:0016209//GO:0004177//GO:0008270//GO:0005509 protein binding//oxidoreductase activity//DNA binding//antioxidant activity//aminopeptidase activity//zinc ion binding//calcium ion binding -- -- KOG4277 Uncharacterized conserved protein, contains thioredoxin domain Cluster-8309.50398 BP_3 29.95 0.42 3763 91090216 XP_968004.1 1600 7.2e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 9.3e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF07393//PF00685 Exocyst complex component Sec10//Sulfotransferase domain GO:0006478//GO:0006887//GO:0048278 peptidyl-tyrosine sulfation//exocytosis//vesicle docking GO:0008146//GO:0008476 sulfotransferase activity//protein-tyrosine sulfotransferase activity GO:0005737 cytoplasm KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.50399 BP_3 310.09 18.11 1117 270011245 EFA07693.1 507 1.2e-48 hypothetical protein TcasGA2_TC030782, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X3B2 187 6.2e-13 Adipocyte plasma membrane-associated protein OS=Salmo salar GN=apmap PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG1520 Predicted alkaloid synthase/Surface mucin Hemomucin Cluster-8309.504 BP_3 35.14 1.34 1554 642937330 XP_966361.3 766 1.5e-78 PREDICTED: serine proteinase stubble, partial [Tribolium castaneum] 642937329 XM_961268.2 64 1.84232e-22 PREDICTED: Tribolium castaneum serine protease P126 (LOC654852), partial mRNA -- -- -- -- Q05319 270 2.0e-22 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF02060 Slow voltage-gated potassium channel GO:0006813//GO:0006811 potassium ion transport//ion transport GO:0005249 voltage-gated potassium channel activity GO:0008076//GO:0016020 voltage-gated potassium channel complex//membrane -- -- Cluster-8309.50400 BP_3 142.01 8.79 1070 91092208 XP_969730.1 1137 1.0e-121 PREDICTED: protein unc-50 homolog [Tribolium castaneum]>gi|270014482|gb|EFA10930.1| hypothetical protein TcasGA2_TC001757 [Tribolium castaneum] 602644740 XM_007428757.1 50 7.61834e-15 PREDICTED: Python bivittatus unc-50 homolog (C. elegans) (UNC50), transcript variant X5, mRNA -- -- -- -- Q9VHN5 860 5.4e-91 Protein unc-50 homolog OS=Drosophila melanogaster GN=CG9773 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3012 Uncharacterized conserved protein Cluster-8309.50401 BP_3 1.98 0.44 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00879//PF04446 Defensin propeptide//tRNAHis guanylyltransferase GO:0006400//GO:0006952 tRNA modification//defense response GO:0000287//GO:0008193 magnesium ion binding//tRNA guanylyltransferase activity -- -- -- -- Cluster-8309.50408 BP_3 8.52 0.49 1124 546674361 ERL85748.1 582 2.4e-57 hypothetical protein D910_03163 [Dendroctonus ponderosae] -- -- -- -- -- K02216 CHK1 serine/threonine-protein kinase Chk1 http://www.genome.jp/dbget-bin/www_bget?ko:K02216 O35280 228 1.1e-17 Serine/threonine-protein kinase Chk1 OS=Mus musculus GN=Chek1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50409 BP_3 127.00 5.24 1460 91094423 XP_969158.1 456 1.3e-42 PREDICTED: integrator complex subunit 12 [Tribolium castaneum]>gi|270016363|gb|EFA12809.1| hypothetical protein TcasGA2_TC001873 [Tribolium castaneum] -- -- -- -- -- K13149 INTS12 integrator complex subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13149 Q6IQU7 157 2.4e-09 Integrator complex subunit 12 OS=Danio rerio GN=ints12 PE=2 SV=1 PF00130//PF05715//PF16866//PF09726//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Piccolo Zn-finger//PHD-finger//Transmembrane protein//PHD-finger GO:0035556 intracellular signal transduction GO:0046872//GO:0005515 metal ion binding//protein binding GO:0016021//GO:0045202 integral component of membrane//synapse -- -- Cluster-8309.50410 BP_3 657.50 4.99 6644 478256693 ENN76875.1 1740 7.4e-191 hypothetical protein YQE_06716, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PCB5 884 5.5e-93 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 PF05059//PF06151 Orbivirus VP4 core protein//Trehalose receptor GO:0050912//GO:0007187//GO:0007607 detection of chemical stimulus involved in sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//obsolete taste perception GO:0008527 taste receptor activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4425 Uncharacterized conserved protein Cluster-8309.50412 BP_3 323.00 18.03 1155 91079640 XP_968044.1 741 8.9e-76 PREDICTED: OCIA domain-containing protein 1 [Tribolium castaneum]>gi|270003372|gb|EEZ99819.1| hypothetical protein TcasGA2_TC002599 [Tribolium castaneum] 642917740 XM_962951.2 61 6.32761e-21 PREDICTED: Tribolium castaneum OCIA domain-containing protein 1 (LOC656418), mRNA -- -- -- -- Q28X44 416 1.8e-39 OCIA domain-containing protein 1 OS=Drosophila pseudoobscura pseudoobscura GN=GA12348 PE=3 SV=1 PF02637 GatB domain -- -- GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor -- -- -- -- Cluster-8309.50413 BP_3 270.00 4.27 3342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03324 Herpesvirus DNA helicase/primase complex associated protein GO:0019079 viral genome replication -- -- -- -- -- -- Cluster-8309.50414 BP_3 18.87 1.02 1184 642913058 XP_008201370.1 993 5.5e-105 PREDICTED: zinc finger protein 557-like [Tribolium castaneum]>gi|270001933|gb|EEZ98380.1| hypothetical protein TcasGA2_TC000840 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 223 4.4e-17 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF06467//PF16622//PF00096//PF13465//PF02053 MYM-type Zinc finger with FCS sequence motif//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain//Gene 66 (IR5) protein -- -- GO:0008270//GO:0005488//GO:0046872 zinc ion binding//binding//metal ion binding -- -- -- -- Cluster-8309.50415 BP_3 126.41 4.02 1808 642917276 XP_008199231.1 1232 1.6e-132 PREDICTED: capon-like protein isoform X1 [Tribolium castaneum] 685047512 LN596024.1 38 6.10712e-08 Cyprinus carpio genome assembly common carp genome ,scaffold 000002447 K16513 NOS1AP, CAPON carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein http://www.genome.jp/dbget-bin/www_bget?ko:K16513 O54960 255 1.3e-20 Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Rattus norvegicus GN=Nos1ap PE=1 SV=1 PF00640 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4815 Muscular protein implicated in muscular dystrophy phenotype Cluster-8309.50416 BP_3 141.17 5.56 1515 123482337 XP_001323756.1 297 3.6e-24 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121906627|gb|EAY11533.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K06694 PSMD10 26S proteasome non-ATPase regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06694 O70511 257 6.4e-21 Ankyrin-3 OS=Rattus norvegicus GN=Ank3 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50418 BP_3 493.82 3.91 6384 283046724 NP_001164308.1 351 8.3e-30 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 275 2.2e-22 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF13606//PF00096//PF04988//PF09153//PF07535//PF00520 Ankyrin repeat//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//Domain of unknown function (DUF1938)//DBF zinc finger//Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005515//GO:0003677//GO:0046872//GO:0008270//GO:0005216//GO:0003676 protein binding//DNA binding//metal ion binding//zinc ion binding//ion channel activity//nucleic acid binding GO:0005634//GO:0005737//GO:0016020 nucleus//cytoplasm//membrane -- -- Cluster-8309.50422 BP_3 41.13 0.52 4132 642935910 XP_008198225.1 1993 2.1e-220 PREDICTED: BMP-binding endothelial regulator protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8U9 947 1.7e-100 BMP-binding endothelial regulator protein OS=Homo sapiens GN=BMPER PE=1 SV=3 PF01479//PF00093 S4 domain//von Willebrand factor type C domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- -- -- Cluster-8309.50423 BP_3 199.49 2.56 4044 642935910 XP_008198225.1 1985 1.8e-219 PREDICTED: BMP-binding endothelial regulator protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8U9 950 7.5e-101 BMP-binding endothelial regulator protein OS=Homo sapiens GN=BMPER PE=1 SV=3 PF00093//PF01479 von Willebrand factor type C domain//S4 domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.50425 BP_3 97.64 1.19 4237 642918984 XP_008191685.1 4678 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X6 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.31948e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122//PF05109 E1-E2 ATPase//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058 viral life cycle GO:0000166//GO:0046872 nucleotide binding//metal ion binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.50427 BP_3 83.90 1.41 3166 546673801 ERL85345.1 1621 2.2e-177 hypothetical protein D910_02765 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GPJ5 767 9.7e-80 Leucine-rich repeat-containing protein 40 OS=Xenopus laevis GN=lrrc40 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.50428 BP_3 210.70 14.06 1014 642919633 XP_008191999.1 271 2.5e-21 PREDICTED: dopamine N acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94521 150 1.1e-08 Dopamine N-acetyltransferase OS=Drosophila melanogaster GN=Dat PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50431 BP_3 28.79 0.33 4478 91092194 XP_969216.1 543 3.2e-52 PREDICTED: ceramide kinase [Tribolium castaneum]>gi|270014479|gb|EFA10927.1| hypothetical protein TcasGA2_TC001754 [Tribolium castaneum] -- -- -- -- -- K04715 E2.7.1.138, CERK ceramide kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04715 Q8K4Q7 205 2.0e-14 Ceramide kinase OS=Mus musculus GN=Cerk PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1115 Ceramide kinase Cluster-8309.50432 BP_3 402.87 9.39 2359 91092194 XP_969216.1 1766 2.5e-194 PREDICTED: ceramide kinase [Tribolium castaneum]>gi|270014479|gb|EFA10927.1| hypothetical protein TcasGA2_TC001754 [Tribolium castaneum] -- -- -- -- -- K04715 E2.7.1.138, CERK ceramide kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04715 Q8TCT0 672 7.5e-69 Ceramide kinase OS=Homo sapiens GN=CERK PE=1 SV=1 PF00781//PF02976 Diacylglycerol kinase catalytic domain//DNA mismatch repair enzyme MutH GO:0009395//GO:0007205//GO:0046486 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//glycerolipid metabolic process GO:0004519//GO:0004143//GO:0003677//GO:0016301 endonuclease activity//diacylglycerol kinase activity//DNA binding//kinase activity -- -- KOG1115 Ceramide kinase Cluster-8309.50434 BP_3 59.35 1.45 2268 478253865 ENN74157.1 915 1.2e-95 hypothetical protein YQE_09130, partial [Dendroctonus ponderosae]>gi|546684674|gb|ERL94291.1| hypothetical protein D910_11572 [Dendroctonus ponderosae] -- -- -- -- -- K04715 E2.7.1.138, CERK ceramide kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04715 Q8TCT0 371 5.8e-34 Ceramide kinase OS=Homo sapiens GN=CERK PE=1 SV=1 PF00781 Diacylglycerol kinase catalytic domain -- -- GO:0016301 kinase activity -- -- KOG1115 Ceramide kinase Cluster-8309.50436 BP_3 12.00 5.01 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09815 XK-related protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50437 BP_3 181.32 5.06 2020 546676350 ERL87377.1 1897 1.4e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.2e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.50438 BP_3 253.00 7.12 2005 91083247 XP_973990.1 1467 1.0e-159 PREDICTED: GDP-fucose protein O-fucosyltransferase 1 [Tribolium castaneum] 195149693 XM_002015755.1 56 6.69035e-18 Drosophila persimilis GL11249 (Dper\GL11249), mRNA K03691 POFUT peptide-O-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03691 Q9V6X7 1207 5.9e-131 GDP-fucose protein O-fucosyltransferase 1 OS=Drosophila melanogaster GN=O-fut1 PE=1 SV=1 PF11547 E3 ubiquitin ligase EDD -- -- GO:0043130 ubiquitin binding -- -- KOG3849 GDP-fucose protein O-fucosyltransferase Cluster-8309.50439 BP_3 6.00 0.80 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50440 BP_3 97.00 10.48 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10808 Protein of unknown function (DUF2542) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50441 BP_3 160.27 2.18 3829 642910285 XP_008198690.1 2416 1.8e-269 PREDICTED: LOW QUALITY PROTEIN: solute carrier organic anion transporter family member 4C1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R3L5 694 3.4e-71 Solute carrier organic anion transporter family member 3A1 OS=Mus musculus GN=Slco3a1 PE=2 SV=1 PF03137//PF07690//PF07648//PF00050 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0055085//GO:0006810 transmembrane transport//transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.50442 BP_3 44.00 8.47 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05851 Lentivirus virion infectivity factor (VIF) GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.50443 BP_3 130.42 2.17 3182 91087253 XP_975524.1 233 2.0e-16 PREDICTED: uncharacterized protein LOC664424 [Tribolium castaneum]>gi|270009552|gb|EFA06000.1| hypothetical protein TcasGA2_TC008826 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50444 BP_3 5.11 0.55 740 642920083 XP_008192197.1 289 1.5e-23 PREDICTED: glycogen synthase kinase-3 beta isoform X2 [Tribolium castaneum] 645029971 XM_008210300.1 55 8.62622e-18 PREDICTED: Nasonia vitripennis glycogen synthase kinase-3 beta (LOC100117808), transcript variant X7, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P49841 260 1.4e-21 Glycogen synthase kinase-3 beta OS=Homo sapiens GN=GSK3B PE=1 SV=2 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0658 Glycogen synthase kinase-3 Cluster-8309.50446 BP_3 260.45 8.28 1808 642914299 XP_008201627.1 1721 3.2e-189 PREDICTED: cytosol aminopeptidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K11142 LAP3 cytosol aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11142 Q68FS4 1104 4.7e-119 Cytosol aminopeptidase OS=Rattus norvegicus GN=Lap3 PE=1 SV=1 PF02789//PF03823//PF00883 Cytosol aminopeptidase family, N-terminal domain//Neurokinin B//Cytosol aminopeptidase family, catalytic domain GO:0006508//GO:0007217 proteolysis//tachykinin receptor signaling pathway GO:0004177 aminopeptidase activity GO:0005622 intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.50447 BP_3 46.00 16.07 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50450 BP_3 559.24 17.38 1843 478259581 ENN79434.1 765 2.3e-78 hypothetical protein YQE_04078, partial [Dendroctonus ponderosae]>gi|546686694|gb|ERL95804.1| hypothetical protein D910_00332 [Dendroctonus ponderosae]>gi|546687578|gb|ERL96217.1| hypothetical protein D910_01476 [Dendroctonus ponderosae] -- -- -- -- -- K12193 VPS24, CHMP3 charged multivesicular body protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12193 Q4R574 597 2.9e-60 Charged multivesicular body protein 3 OS=Macaca fascicularis GN=CHMP3 PE=2 SV=3 PF03357 Snf7 GO:0007034 vacuolar transport -- -- -- -- KOG3229 Vacuolar sorting protein VPS24 Cluster-8309.50451 BP_3 43.30 0.45 4916 189237113 XP_971629.2 1209 2.1e-129 PREDICTED: xyloside xylosyltransferase 1 [Tribolium castaneum]>gi|270007231|gb|EFA03679.1| hypothetical protein TcasGA2_TC013781 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBI6 600 3.5e-60 Xyloside xylosyltransferase 1 OS=Homo sapiens GN=XXYLT1 PE=1 SV=1 PF12763//PF13202//PF13499//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0016757//GO:0005509//GO:0005515 transferase activity, transferring glycosyl groups//calcium ion binding//protein binding -- -- KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.50452 BP_3 622.81 3.95 7898 642937296 XP_008198775.1 2919 0.0e+00 PREDICTED: uncharacterized protein LOC658848 isoform X3 [Tribolium castaneum] 642937295 XM_008200553.1 210 6.57748e-103 PREDICTED: Tribolium castaneum uncharacterized LOC658848 (LOC658848), transcript variant X3, mRNA -- -- -- -- Q70EL1 831 9.2e-87 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Homo sapiens GN=USP54 PE=1 SV=4 PF09663//PF03311//PF11808//PF00126 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD)//Cornichon protein//Domain of unknown function (DUF3329)//Bacterial regulatory helix-turn-helix protein, lysR family GO:0016310//GO:0035556//GO:0006807//GO:0006355 phosphorylation//intracellular signal transduction//nitrogen compound metabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0004673//GO:0016812 transcription factor activity, sequence-specific DNA binding//protein histidine kinase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0005667//GO:0009365//GO:0016020 transcription factor complex//protein histidine kinase complex//membrane KOG1887 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.50453 BP_3 143.29 4.48 1834 478252879 ENN73268.1 274 2.0e-21 hypothetical protein YQE_10163, partial [Dendroctonus ponderosae]>gi|546673885|gb|ERL85407.1| hypothetical protein D910_02827, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50456 BP_3 5.29 1.03 539 270001425 EEZ97872.1 707 3.6e-72 hypothetical protein TcasGA2_TC000254 [Tribolium castaneum] 755849387 XM_011295091.1 87 1.0037e-35 PREDICTED: Musca domestica potassium channel subfamily T member 2 (LOC101895809), transcript variant X3, mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q5JUK3 376 3.6e-35 Potassium channel subfamily T member 1 OS=Homo sapiens GN=KCNT1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50458 BP_3 52.00 4.20 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5046 BP_3 2.00 0.41 528 91084541 XP_972999.1 241 3.9e-18 PREDICTED: vacuolar protein sorting-associated protein 26B-like [Tribolium castaneum]>gi|270008666|gb|EFA05114.1| hypothetical protein TcasGA2_TC015215 [Tribolium castaneum] -- -- -- -- -- K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q8C0E2 190 1.3e-13 Vacuolar protein sorting-associated protein 26B OS=Mus musculus GN=Vps26b PE=1 SV=1 -- -- GO:0007034 vacuolar transport -- -- GO:0030904 retromer complex KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.50462 BP_3 367.42 4.76 4011 642910697 XP_008200065.1 946 5.3e-99 PREDICTED: uncharacterized protein LOC103314827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09107 Elongation factor SelB, winged helix GO:0001514//GO:0006448 selenocysteine incorporation//regulation of translational elongation GO:0003723//GO:0005525//GO:0003746 RNA binding//GTP binding//translation elongation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome -- -- Cluster-8309.50463 BP_3 42.00 2.60 1070 817054398 XP_012267380.1 183 4.2e-11 PREDICTED: THAP domain-containing protein 1-like isoform X2 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.50466 BP_3 62.33 1.54 2238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50467 BP_3 462.46 7.77 3160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50468 BP_3 1365.48 5.55 12152 642913340 XP_008195316.1 15018 0.0e+00 PREDICTED: WD repeat and FYVE domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270002019|gb|EEZ98466.1| hypothetical protein TcasGA2_TC000957 [Tribolium castaneum] 572266379 XM_006611237.1 593 0 PREDICTED: Apis dorsata WD repeat and FYVE domain-containing protein 3-like (LOC102679853), mRNA -- -- -- -- Q8IZQ1 5442 0.0e+00 WD repeat and FYVE domain-containing protein 3 OS=Homo sapiens GN=WDFY3 PE=1 SV=2 PF00400//PF01363 WD domain, G-beta repeat//FYVE zinc finger -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.50470 BP_3 302.37 4.96 3232 642915724 XP_008190776.1 1435 8.4e-156 PREDICTED: serine/threonine-protein kinase VRK1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q32PI1 400 3.6e-37 Serine/threonine-protein kinase VRK1 OS=Bos taurus GN=VRK1 PE=2 SV=1 PF07714//PF00069//PF03047 Protein tyrosine kinase//Protein kinase domain//COMC family GO:0007165//GO:0006468 signal transduction//protein phosphorylation GO:0005524//GO:0004672//GO:0005186 ATP binding//protein kinase activity//pheromone activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.50471 BP_3 106.34 3.57 1729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00260 Protamine P1 GO:0007283 spermatogenesis GO:0003677 DNA binding GO:0000786//GO:0005634 nucleosome//nucleus -- -- Cluster-8309.50473 BP_3 5.00 1.38 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50474 BP_3 118.68 2.57 2516 642925371 XP_008194521.1 312 1.1e-25 PREDICTED: zinc finger protein 600-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 222 1.2e-16 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF04988//PF13465//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.50475 BP_3 24.15 1.06 1393 546673850 ERL85380.1 1204 2.2e-129 hypothetical protein D910_02800 [Dendroctonus ponderosae] 157136796 XM_001656862.1 144 5.55843e-67 Aedes aegypti AAEL003514-RA mRNA K11131 DKC1, NOLA4, CBF5 H/ACA ribonucleoprotein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11131 O44081 1174 2.7e-127 H/ACA ribonucleoprotein complex subunit 4 OS=Drosophila melanogaster GN=Nop60B PE=1 SV=1 PF01509 TruB family pseudouridylate synthase (N terminal domain) GO:0006396 RNA processing -- -- -- -- KOG2529 Pseudouridine synthase Cluster-8309.50476 BP_3 281.61 2.69 5343 390362249 XP_001190749.2 1582 1.3e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 3.0e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF01637//PF13606//PF00866//PF00023//PF00906 Archaeal ATPase//Ankyrin repeat//Ring hydroxylating beta subunit//Ankyrin repeat//Hepatitis core antigen GO:0009405//GO:0055114//GO:0006725 pathogenesis//oxidation-reduction process//cellular aromatic compound metabolic process GO:0003824//GO:0005524//GO:0005198//GO:0005515 catalytic activity//ATP binding//structural molecule activity//protein binding -- -- -- -- Cluster-8309.5048 BP_3 1.00 0.80 346 817182783 XP_012272876.1 190 2.1e-12 PREDICTED: dipeptidase 1-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50481 BP_3 9.00 4.51 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50483 BP_3 17.00 1.70 775 808859777 KKF11870.1 1235 3.1e-133 Tubulin alpha-1C chain [Larimichthys crocea] 262401096 FJ774729.1 736 0 Scylla paramamosain alpha-I tubulin mRNA, partial cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q25008 1257 3.6e-137 Tubulin alpha-1 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.50484 BP_3 3.00 1.39 394 330976859 AEC48728.1 565 7.8e-56 alpha-tubulin [Eriocheir sinensis] 330976858 HQ436507.1 194 2.37129e-95 Eriocheir sinensis alpha-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P41383 548 3.0e-55 Tubulin alpha-2/alpha-4 chain OS=Patella vulgata GN=TUB2 PE=2 SV=1 PF13912//PF00091//PF11057 C2H2-type zinc finger//Tubulin/FtsZ family, GTPase domain//Cortexin of kidney -- -- GO:0046872//GO:0003924 metal ion binding//GTPase activity GO:0031224 intrinsic component of membrane KOG1376 Alpha tubulin Cluster-8309.50487 BP_3 36.10 0.63 3056 642911941 XP_008199031.1 3233 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3 [Tribolium castaneum] 642911942 XM_008200810.1 587 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 Q9ULH1 1729 2.6e-191 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens GN=ASAP1 PE=1 SV=4 PF08397//PF07043//PF01412//PF13606//PF03114//PF00023 IRSp53/MIM homology domain//Protein of unknown function (DUF1328)//Putative GTPase activating protein for Arf//Ankyrin repeat//BAR domain//Ankyrin repeat GO:0007009 plasma membrane organization GO:0005096//GO:0005515 GTPase activator activity//protein binding GO:0005886//GO:0005737 plasma membrane//cytoplasm KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.50488 BP_3 23.00 4.21 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50489 BP_3 309.57 3.93 4092 642935257 XP_008197935.1 679 4.9e-68 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q80WK7 178 2.5e-11 Equilibrative nucleoside transporter 3 OS=Rattus norvegicus GN=Slc29a3 PE=1 SV=2 PF07690//PF01733 Major Facilitator Superfamily//Nucleoside transporter GO:0006810//GO:0015858//GO:0055085 transport//nucleoside transport//transmembrane transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.50492 BP_3 31.89 0.63 2744 91085763 XP_974155.1 1911 4.5e-211 PREDICTED: polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270009999|gb|EFA06447.1| hypothetical protein TcasGA2_TC009329 [Tribolium castaneum] -- -- -- -- -- K00962 pnp, PNPT1 polyribonucleotide nucleotidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00962 Q8K1R3 1319 8.3e-144 Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Mus musculus GN=Pnpt1 PE=1 SV=1 PF03726//PF00575 Polyribonucleotide nucleotidyltransferase, RNA binding domain//S1 RNA binding domain GO:0006144//GO:0006402//GO:0006396//GO:0051252//GO:0006206 purine nucleobase metabolic process//mRNA catabolic process//RNA processing//regulation of RNA metabolic process//pyrimidine nucleobase metabolic process GO:0000175//GO:0003723//GO:0004654//GO:0003676 3'-5'-exoribonuclease activity//RNA binding//polyribonucleotide nucleotidyltransferase activity//nucleic acid binding -- -- KOG1067 Predicted RNA-binding polyribonucleotide nucleotidyltransferase Cluster-8309.50493 BP_3 143.34 1.58 4661 642911186 XP_008199538.1 3936 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911188|ref|XP_008199542.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911190|ref|XP_008199549.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911192|ref|XP_008199550.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum] 198453821 XM_001359317.2 76 1.19679e-28 Drosophila pseudoobscura pseudoobscura GA10452 (Dpse\GA10452), partial mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 3156 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF08702//PF00520 Fibrinogen alpha/beta chain family//Ion transport protein GO:0007165//GO:0055085//GO:0051258//GO:0030168//GO:0006811 signal transduction//transmembrane transport//protein polymerization//platelet activation//ion transport GO:0030674//GO:0005216//GO:0005102 protein binding, bridging//ion channel activity//receptor binding GO:0016020//GO:0005577 membrane//fibrinogen complex KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.50497 BP_3 250.92 1.97 6437 642912571 XP_008200914.1 1898 3.4e-209 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 195 1.16739e-94 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 1025 2.4e-109 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF00617 RasGEF domain GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.50498 BP_3 18.03 1.00 1165 826485719 XP_012539045.1 734 5.8e-75 PREDICTED: ras-related protein Rab6 isoform X1 [Monomorium pharaonis] 721611937 XM_010239811.1 71 1.76038e-26 PREDICTED: Brachypodium distachyon ras-related protein RABH1b (LOC100823113), mRNA K07893 RAB6A Ras-related protein Rab-6A http://www.genome.jp/dbget-bin/www_bget?ko:K07893 O18334 713 6.5e-74 Ras-related protein Rab6 OS=Drosophila melanogaster GN=Rab6 PE=1 SV=1 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily Cluster-8309.505 BP_3 8.96 0.50 1155 642937330 XP_966361.3 774 1.3e-79 PREDICTED: serine proteinase stubble, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 272 8.9e-23 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5050 BP_3 113.68 2.60 2398 827545651 XP_012545324.1 596 1.2e-58 PREDICTED: connectin-like [Bombyx mori] -- -- -- -- -- -- -- -- -- Q01819 529 2.9e-52 Connectin OS=Drosophila melanogaster GN=Con PE=2 SV=2 PF13855//PF00560//PF00664 Leucine rich repeat//Leucine Rich Repeat//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0005515//GO:0042626 ATP binding//protein binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.50502 BP_3 157.53 5.58 1653 91078380 XP_974219.1 194 3.4e-12 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03310//PF02176//PF03145//PF00876 Caulimovirus DNA-binding protein//TRAF-type zinc finger//Seven in absentia protein family//Innexin GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0003677//GO:0008270 DNA binding//zinc ion binding GO:0005921//GO:0005634 gap junction//nucleus -- -- Cluster-8309.50504 BP_3 160.08 1.91 4338 478258110 ENN78248.1 2446 6.6e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 3.50025e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 2.5e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF00400//PF08063//PF01435//PF01433//PF09127 WD domain, G-beta repeat//PADR1 (NUC008) domain//Peptidase family M48//Peptidase family M1//Leukotriene A4 hydrolase, C-terminal GO:0006508//GO:0019370 proteolysis//leukotriene biosynthetic process GO:0008237//GO:0008270//GO:0003950//GO:0004222//GO:0005515 metallopeptidase activity//zinc ion binding//NAD+ ADP-ribosyltransferase activity//metalloendopeptidase activity//protein binding GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.50505 BP_3 44.97 0.43 5283 478258110 ENN78248.1 2446 8.1e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 4.26913e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 3.1e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF01435//PF00400//PF08063//PF09127//PF01433 Peptidase family M48//WD domain, G-beta repeat//PADR1 (NUC008) domain//Leukotriene A4 hydrolase, C-terminal//Peptidase family M1 GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0005515//GO:0004222//GO:0003950//GO:0008270//GO:0008237 protein binding//metalloendopeptidase activity//NAD+ ADP-ribosyltransferase activity//zinc ion binding//metallopeptidase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.50506 BP_3 40.50 0.93 2381 26324131 AAN77377.1 2686 5.4e-301 smooth endoplasmic reticulum calcium ATPase [Porcellio scaber] 378947922 JN986572.1 799 0 Litopenaeus vannamei sarco/endoplasmic reticulum Ca2+-ATPase mRNA, complete cds K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 Q7PPA5 2456 1.0e-275 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Anopheles gambiae GN=Ca-P60A PE=3 SV=5 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.5051 BP_3 1.00 0.31 449 -- -- -- -- -- 462310984 APGK01047133.1 59 3.03849e-20 Dendroctonus ponderosae Seq01047143, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50511 BP_3 139.31 5.13 1601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50512 BP_3 434.44 9.55 2485 270003665 EFA00113.1 1871 1.8e-206 hypothetical protein TcasGA2_TC002929 [Tribolium castaneum] 642916327 XM_008192753.1 606 0 PREDICTED: Tribolium castaneum glucose transporter type 1 (LOC663886), transcript variant X2, mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 Q8IRI6 1796 3.7e-199 Glucose transporter type 1 OS=Drosophila melanogaster GN=Glut1 PE=2 SV=4 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0569 Permease of the major facilitator superfamily Cluster-8309.50513 BP_3 181.21 3.00 3204 270009489 EFA05937.1 1625 7.7e-178 hypothetical protein TcasGA2_TC008753 [Tribolium castaneum] 642929936 XM_008197811.1 369 0 PREDICTED: Tribolium castaneum nucleolar protein 4-like (LOC664605), transcript variant X1, mRNA -- -- -- -- Q96MY1 448 9.6e-43 Nucleolar protein 4-like OS=Homo sapiens GN=NOL4L PE=1 SV=2 PF09026 Centromere protein B dimerisation domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003682 DNA binding//chromatin binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region -- -- Cluster-8309.50515 BP_3 1.68 0.37 513 769856846 XP_011640032.1 138 3.3e-06 PREDICTED: longitudinals lacking protein, isoforms A/B/D/L isoform X39 [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF02892//PF01708//PF13912//PF00096//PF13465 zinc-finger C2H2-type//BED zinc finger//Geminivirus putative movement protein//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0046740 transport of virus in host, cell to cell GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.50517 BP_3 23.45 0.52 2463 642915596 XP_008190681.1 282 3.2e-22 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B-B [Tribolium castaneum] -- -- -- -- -- K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 P22681 141 2.9e-07 E3 ubiquitin-protein ligase CBL OS=Homo sapiens GN=CBL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50521 BP_3 88.00 1.13 4035 546673724 ERL85280.1 3262 0.0e+00 hypothetical protein D910_02701 [Dendroctonus ponderosae] 756767049 KJ699123.1 896 0 Brassicogethes aeneus isolate Wlkp_PL voltage-sensitive sodium channel mRNA, complete cds K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 P35500 2894 0.0e+00 Sodium channel protein para OS=Drosophila melanogaster GN=para PE=2 SV=3 PF00520//PF02163//PF02297 Ion transport protein//Peptidase family M50//Cytochrome oxidase c subunit VIb GO:0055085//GO:0006123//GO:0006508//GO:0006811//GO:0015992 transmembrane transport//mitochondrial electron transport, cytochrome c to oxygen//proteolysis//ion transport//proton transport GO:0004222//GO:0005216//GO:0004129 metalloendopeptidase activity//ion channel activity//cytochrome-c oxidase activity GO:0045277//GO:0016020//GO:0005739 respiratory chain complex IV//membrane//mitochondrion -- -- Cluster-8309.50524 BP_3 103.40 3.28 1812 270009226 EFA05674.1 1385 3.0e-150 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AXF6 733 4.9e-76 SID1 transmembrane family member 1 OS=Mus musculus GN=Sidt1 PE=2 SV=1 PF01040//PF13965 UbiA prenyltransferase family//dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0004659//GO:0051033 prenyltransferase activity//RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.50526 BP_3 154.25 1.25 6221 571535227 XP_006568313.1 6105 0.0e+00 PREDICTED: neurobeachin-like [Apis mellifera] 817185259 XM_012430472.1 851 0 PREDICTED: Orussus abietinus neurobeachin (LOC105702683), transcript variant X7, mRNA -- -- -- -- Q8NFP9 3084 0.0e+00 Neurobeachin OS=Homo sapiens GN=NBEA PE=1 SV=3 PF10508//PF10798 Proteasome non-ATPase 26S subunit//Biofilm development protein YmgB/AriR GO:0071229//GO:0042710//GO:0043248 cellular response to acid chemical//biofilm formation//proteasome assembly -- -- -- -- KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.50527 BP_3 72.00 2.62 1618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50528 BP_3 105.25 2.89 2047 642936881 XP_008194325.1 316 3.0e-26 PREDICTED: uncharacterized protein LOC103313261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50532 BP_3 364.82 16.31 1370 91081201 XP_975610.1 1253 4.5e-135 PREDICTED: peptidylglycine alpha-hydroxylating monooxygenase [Tribolium castaneum]>gi|270005264|gb|EFA01712.1| hypothetical protein TcasGA2_TC007292 [Tribolium castaneum] -- -- -- -- -- K00504 PAM, PHM peptidylglycine monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00504 O01404 924 2.6e-98 Peptidylglycine alpha-hydroxylating monooxygenase OS=Drosophila melanogaster GN=Phm PE=1 SV=2 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0006518//GO:0055114 peptide metabolic process//oxidation-reduction process GO:0004504//GO:0005507//GO:0016715//GO:0004497 peptidylglycine monooxygenase activity//copper ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity GO:0016020 membrane KOG3567 Peptidylglycine alpha-amidating monooxygenase Cluster-8309.50534 BP_3 711.22 17.46 2255 91092806 XP_967025.1 2140 1.0e-237 PREDICTED: protein henna [Tribolium castaneum]>gi|270003060|gb|EEZ99507.1| hypothetical protein TcasGA2_TC000087 [Tribolium castaneum] -- -- -- -- -- K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 1717 4.8e-190 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF00351//PF01842 Biopterin-dependent aromatic amino acid hydroxylase//ACT domain GO:0008152//GO:0006559//GO:0009094//GO:0000162//GO:0006571//GO:0055114 metabolic process//L-phenylalanine catabolic process//L-phenylalanine biosynthetic process//tryptophan biosynthetic process//tyrosine biosynthetic process//oxidation-reduction process GO:0016714//GO:0016597//GO:0005506//GO:0004505 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//amino acid binding//iron ion binding//phenylalanine 4-monooxygenase activity -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.50535 BP_3 405.29 9.86 2273 91092806 XP_967025.1 2140 1.1e-237 PREDICTED: protein henna [Tribolium castaneum]>gi|270003060|gb|EEZ99507.1| hypothetical protein TcasGA2_TC000087 [Tribolium castaneum] -- -- -- -- -- K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 1717 4.9e-190 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF00351//PF01842 Biopterin-dependent aromatic amino acid hydroxylase//ACT domain GO:0008152//GO:0000162//GO:0006571//GO:0055114//GO:0006559//GO:0009094 metabolic process//tryptophan biosynthetic process//tyrosine biosynthetic process//oxidation-reduction process//L-phenylalanine catabolic process//L-phenylalanine biosynthetic process GO:0016714//GO:0005506//GO:0004505//GO:0016597 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//iron ion binding//phenylalanine 4-monooxygenase activity//amino acid binding -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.50537 BP_3 342.57 4.94 3632 478258640 ENN78690.1 1014 6.2e-107 hypothetical protein YQE_04862, partial [Dendroctonus ponderosae]>gi|546685796|gb|ERL95245.1| hypothetical protein D910_12512 [Dendroctonus ponderosae] -- -- -- -- -- K07966 B4GALT1 beta-1,4-galactosyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07966 Q80WN7 486 4.3e-47 Beta-1,4-galactosyltransferase 4 OS=Cricetulus griseus GN=B4GALT4 PE=2 SV=1 PF05679//PF03279 Chondroitin N-acetylgalactosaminyltransferase//Bacterial lipid A biosynthesis acyltransferase -- -- GO:0008376//GO:0016740 acetylgalactosaminyltransferase activity//transferase activity GO:0016021//GO:0032580 integral component of membrane//Golgi cisterna membrane KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.50539 BP_3 603.12 2.78 10756 642914930 XP_008190446.1 6308 0.0e+00 PREDICTED: protein slit isoform X3 [Tribolium castaneum] 462424845 APGK01016975.1 99 4.54251e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 4797 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF00560//PF07645//PF13639//PF05463//PF00097//PF00008//PF14634//PF13855 Leucine Rich Repeat//Calcium-binding EGF domain//Ring finger domain//Sclerostin (SOST)//Zinc finger, C3HC4 type (RING finger)//EGF-like domain//zinc-RING finger domain//Leucine rich repeat -- -- GO:0008270//GO:0005509//GO:0005515//GO:0046872 zinc ion binding//calcium ion binding//protein binding//metal ion binding GO:0005615 extracellular space KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.50540 BP_3 29.46 0.88 1899 642914052 XP_969243.3 1511 7.6e-165 PREDICTED: sorting nexin-6 isoform X2 [Tribolium castaneum]>gi|270001606|gb|EEZ98053.1| hypothetical protein TcasGA2_TC000458 [Tribolium castaneum] 697469095 XM_009669926.1 81 8.01687e-32 PREDICTED: Struthio camelus australis sorting nexin 6 (SNX6), transcript variant X2, mRNA K17920 SNX5_6_32 sorting nexin-5/6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K17920 Q5R613 931 5.6e-99 Sorting nexin-6 OS=Pongo abelii GN=SNX6 PE=2 SV=1 PF01916//PF04632//PF00787 Deoxyhypusine synthase//Fusaric acid resistance protein family//PX domain GO:0007154//GO:0006810//GO:0008612 cell communication//transport//peptidyl-lysine modification to peptidyl-hypusine GO:0035091 phosphatidylinositol binding GO:0005886 plasma membrane KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.50541 BP_3 188.20 4.17 2466 91084581 XP_973970.1 693 7.0e-70 PREDICTED: signal peptide peptidase-like 3 isoform X1 [Tribolium castaneum]>gi|270008893|gb|EFA05341.1| hypothetical protein TcasGA2_TC015505 [Tribolium castaneum] 27820031 BT003288.1 56 8.25596e-18 Drosophila melanogaster GM06145 full insert cDNA K09598 SPPL3 signal peptide peptidase-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09598 Q8TCT6 445 1.7e-42 Signal peptide peptidase-like 3 OS=Homo sapiens GN=SPPL3 PE=1 SV=1 PF04258 Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.50542 BP_3 49.00 3.79 915 642926314 XP_008194873.1 883 2.4e-92 PREDICTED: bicaudal D-related protein homolog isoform X1 [Tribolium castaneum]>gi|642926316|ref|XP_008194874.1| PREDICTED: bicaudal D-related protein homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K16756 CCDC64 coiled-coil domain-containing protein 64 http://www.genome.jp/dbget-bin/www_bget?ko:K16756 Q8SWR2 446 4.7e-43 Bicaudal D-related protein homolog OS=Drosophila melanogaster GN=CG17365 PE=2 SV=1 PF01920//PF13851//PF10473 Prefoldin subunit//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006457//GO:0048870 protein folding//cell motility GO:0051082//GO:0042803//GO:0008134//GO:0045502 unfolded protein binding//protein homodimerization activity//transcription factor binding//dynein binding GO:0016272//GO:0030286//GO:0031514//GO:0005667 prefoldin complex//dynein complex//motile cilium//transcription factor complex -- -- Cluster-8309.50543 BP_3 605.85 8.77 3620 189238478 XP_968757.2 850 6.4e-88 PREDICTED: bicaudal D-related protein homolog isoform X2 [Tribolium castaneum] 195590137 XM_002084767.1 68 2.59687e-24 Drosophila simulans GD14464 (Dsim\GD14464), mRNA K16756 CCDC64 coiled-coil domain-containing protein 64 http://www.genome.jp/dbget-bin/www_bget?ko:K16756 Q8SWR2 443 4.1e-42 Bicaudal D-related protein homolog OS=Drosophila melanogaster GN=CG17365 PE=2 SV=1 PF10473//PF13851//PF01920//PF01544 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Growth-arrest specific micro-tubule binding//Prefoldin subunit//CorA-like Mg2+ transporter protein GO:0006457//GO:0055085//GO:0030001//GO:0048870 protein folding//transmembrane transport//metal ion transport//cell motility GO:0046873//GO:0051082//GO:0042803//GO:0008134//GO:0045502 metal ion transmembrane transporter activity//unfolded protein binding//protein homodimerization activity//transcription factor binding//dynein binding GO:0016020//GO:0016272//GO:0031514//GO:0030286//GO:0005667 membrane//prefoldin complex//motile cilium//dynein complex//transcription factor complex -- -- Cluster-8309.50544 BP_3 39.00 1.69 1407 546681029 ERL91194.1 212 2.4e-14 hypothetical protein D910_08533 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01290 Thymosin beta-4 family GO:0007015 actin filament organization GO:0003785 actin monomer binding -- -- -- -- Cluster-8309.50548 BP_3 556.11 1.91 14311 189241098 XP_971301.2 12901 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13D [Tribolium castaneum] -- -- -- -- -- K19527 VPS13D vacuolar protein sorting-associated protein 13D http://www.genome.jp/dbget-bin/www_bget?ko:K19527 Q5THJ4 2461 1.6e-275 Vacuolar protein sorting-associated protein 13D OS=Homo sapiens GN=VPS13D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.50549 BP_3 69.35 0.64 5482 642939323 XP_969087.2 928 8.8e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.74475e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF03876//PF01588 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Putative tRNA binding domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0000049 DNA-directed RNA polymerase activity//tRNA binding GO:0005730 nucleolus KOG2241 tRNA-binding protein Cluster-8309.5055 BP_3 13.00 0.93 963 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50551 BP_3 238.65 1.48 8056 642934473 XP_008197678.1 5966 0.0e+00 PREDICTED: kinase D-interacting substrate of 220 kDa isoform X2 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 3.3e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF00536//PF06553//PF13606//PF00023 SAM domain (Sterile alpha motif)//BNIP3//Ankyrin repeat//Ankyrin repeat GO:0043065 positive regulation of apoptotic process GO:0005515 protein binding GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.50555 BP_3 24.82 0.34 3768 270009834 EFA06282.1 2409 1.1e-268 hypothetical protein TcasGA2_TC009148 [Tribolium castaneum] -- -- -- -- -- K12600 SKI3, TTC37 superkiller protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12600 Q6PGP7 940 1.0e-99 Tetratricopeptide repeat protein 37 OS=Homo sapiens GN=TTC37 PE=1 SV=1 PF13414//PF12513//PF13176//PF13371//PF00515//PF13374//PF13174//PF13181 TPR repeat//Mitochondrial degradasome RNA helicase subunit C terminal//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0016817//GO:0005515 hydrolase activity, acting on acid anhydrides//protein binding -- -- KOG1127 TPR repeat-containing protein Cluster-8309.50556 BP_3 617.12 13.17 2550 91088067 XP_967758.1 898 1.2e-93 PREDICTED: UPF0047 protein C4A8.02c [Tribolium castaneum]>gi|270011871|gb|EFA08319.1| hypothetical protein TcasGA2_TC005961 [Tribolium castaneum] 642931137 XM_962665.2 338 1.47429e-174 PREDICTED: Tribolium castaneum UPF0047 protein C4A8.02c (LOC656116), mRNA -- -- -- -- P0AF49 389 5.3e-36 UPF0047 protein YjbQ OS=Escherichia coli O157:H7 GN=yjbQ PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3267 Uncharacterized conserved protein Cluster-8309.50557 BP_3 20.00 0.59 1938 -- -- -- -- -- 462278079 APGK01058767.1 46 2.34094e-12 Dendroctonus ponderosae Seq01058777, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50558 BP_3 42.68 0.60 3718 546684844 ERL94426.1 2239 5.7e-249 hypothetical protein D910_11704 [Dendroctonus ponderosae] -- -- -- -- -- K01769 E4.6.1.2 guanylate cyclase, other http://www.genome.jp/dbget-bin/www_bget?ko:K01769 Q9VEU6 1251 8.6e-136 Soluble guanylate cyclase 89Da OS=Drosophila melanogaster GN=Gyc-89Da PE=1 SV=2 PF07701//PF00211//PF07700 Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain//Haem-NO-binding GO:0035556//GO:0009190//GO:0006182//GO:0046039//GO:0006144 intracellular signal transduction//cyclic nucleotide biosynthetic process//cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process GO:0004383//GO:0016849//GO:0020037 guanylate cyclase activity//phosphorus-oxygen lyase activity//heme binding -- -- KOG4171 Adenylate/guanylate kinase Cluster-8309.50559 BP_3 460.68 3.72 6256 478257502 ENN77658.1 2749 7.0e-308 hypothetical protein YQE_05952, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q13439 325 3.4e-28 Golgin subfamily A member 4 OS=Homo sapiens GN=GOLGA4 PE=1 SV=1 PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.50560 BP_3 7.00 1.15 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50562 BP_3 94.75 0.77 6257 546674893 ERL86179.1 2180 6.7e-242 hypothetical protein D910_03592, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 1.87184e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1751 1.5e-193 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.50564 BP_3 525.79 19.07 1621 642919866 XP_008192101.1 1717 8.4e-189 PREDICTED: uridine 5'-monophosphate synthase [Tribolium castaneum] -- -- -- -- -- K13421 UMPS uridine monophosphate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K13421 Q01637 1272 1.4e-138 Uridine 5'-monophosphate synthase OS=Drosophila melanogaster GN=r-l PE=2 SV=2 PF00156//PF00215 Phosphoribosyl transferase domain//Orotidine 5'-phosphate decarboxylase / HUMPS family GO:0006207//GO:0006206//GO:0009116 'de novo' pyrimidine nucleobase biosynthetic process//pyrimidine nucleobase metabolic process//nucleoside metabolic process GO:0004590 orotidine-5'-phosphate decarboxylase activity -- -- KOG1377 Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase Cluster-8309.50567 BP_3 94.21 0.85 5646 642917556 XP_008191255.1 3201 0.0e+00 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.87786e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 257 2.4e-20 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621//PF10541 RhoGEF domain//Nuclear envelope localisation domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50568 BP_3 166.06 0.52 15783 826444743 XP_012531039.1 5861 0.0e+00 PREDICTED: voltage-dependent calcium channel type A subunit alpha-1 isoform X7 [Monomorium pharaonis] 259906454 NM_001165911.1 922 0 Tribolium castaneum cacophony A (Cac), mRNA >gnl|BL_ORD_ID|7385018 Tribolium castaneum cacophony A (CAC) mRNA, complete cds -- -- -- -- C9D7C2 3178 0.0e+00 Voltage-dependent calcium channel type A subunit alpha-1 OS=Apis mellifera GN=CAC PE=2 SV=1 PF01635//PF00520//PF00230//PF02561//PF14138//PF00036//PF13405 Coronavirus M matrix/glycoprotein//Ion transport protein//Major intrinsic protein//Flagellar protein FliS//Cytochrome c oxidase assembly protein COX16//EF hand//EF-hand domain GO:0055085//GO:0019058//GO:0006810//GO:0006811 transmembrane transport//viral life cycle//transport//ion transport GO:0005215//GO:0005509//GO:0005216 transporter activity//calcium ion binding//ion channel activity GO:0009288//GO:0016020//GO:0031966 bacterial-type flagellum//membrane//mitochondrial membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.5057 BP_3 6.00 0.45 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50570 BP_3 22.54 0.60 2111 642918880 XP_008191625.1 1769 1.0e-194 PREDICTED: probable ATP-dependent RNA helicase DDX49 [Tribolium castaneum] 471223534 XM_004030496.1 44 3.30349e-11 Ichthyophthirius multifiliis hypothetical protein (IMG5_158860) mRNA, partial cds K14778 DDX49, DBP8 ATP-dependent RNA helicase DDX49/DBP8 http://www.genome.jp/dbget-bin/www_bget?ko:K14778 Q9Y6V7 1283 9.5e-140 Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens GN=DDX49 PE=1 SV=1 PF00176//PF04851//PF00270 SNF2 family N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676//GO:0016787//GO:0003677 ATP binding//nucleic acid binding//hydrolase activity//DNA binding -- -- KOG0340 ATP-dependent RNA helicase Cluster-8309.50571 BP_3 38.99 1.89 1284 642918880 XP_008191625.1 1026 8.9e-109 PREDICTED: probable ATP-dependent RNA helicase DDX49 [Tribolium castaneum] 769857380 XM_011642027.1 37 1.54734e-07 PREDICTED: Pogonomyrmex barbatus probable ATP-dependent RNA helicase DDX10 (LOC105429200), mRNA K14778 DDX49, DBP8 ATP-dependent RNA helicase DDX49/DBP8 http://www.genome.jp/dbget-bin/www_bget?ko:K14778 Q9Y6V7 778 2.1e-81 Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens GN=DDX49 PE=1 SV=1 PF00270//PF04851//PF00176 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0005524//GO:0003676//GO:0003677//GO:0016787 ATP binding//nucleic acid binding//DNA binding//hydrolase activity -- -- KOG0340 ATP-dependent RNA helicase Cluster-8309.50572 BP_3 592.46 18.10 1869 642918880 XP_008191625.1 1769 9.1e-195 PREDICTED: probable ATP-dependent RNA helicase DDX49 [Tribolium castaneum] 471223534 XM_004030496.1 44 2.9184e-11 Ichthyophthirius multifiliis hypothetical protein (IMG5_158860) mRNA, partial cds K14778 DDX49, DBP8 ATP-dependent RNA helicase DDX49/DBP8 http://www.genome.jp/dbget-bin/www_bget?ko:K14778 Q9Y6V7 1283 8.4e-140 Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens GN=DDX49 PE=1 SV=1 PF00270//PF04851//PF00176 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0005524//GO:0003676//GO:0003677//GO:0016787 ATP binding//nucleic acid binding//DNA binding//hydrolase activity -- -- KOG0340 ATP-dependent RNA helicase Cluster-8309.50573 BP_3 29.00 0.44 3502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50579 BP_3 39.28 0.98 2227 642912148 XP_008200826.1 1887 2.2e-208 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 484 4.5e-47 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF07196//PF01757 Flagellin hook IN motif//Acyltransferase family GO:0006928//GO:0044781 movement of cell or subcellular component//bacterial-type flagellum organization GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0009288 bacterial-type flagellum -- -- Cluster-8309.50581 BP_3 6.00 0.44 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50582 BP_3 7.00 1.46 522 546678121 ERL88830.1 251 2.6e-19 hypothetical protein D910_06212 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50584 BP_3 25.29 0.34 3908 642930901 XP_008196133.1 762 1.1e-77 PREDICTED: protein suppressor of sable isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22293 345 1.0e-30 Protein suppressor of sable OS=Drosophila melanogaster GN=su(s) PE=1 SV=2 PF08108//PF06440//PF00642 Halocidin family//DNA polymerase III, theta subunit//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006260//GO:0042742 DNA replication//defense response to bacterium GO:0046872//GO:0003887//GO:0003677 metal ion binding//DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.50587 BP_3 560.44 20.29 1623 91076806 XP_974293.1 777 8.4e-80 PREDICTED: sorting nexin-12 [Tribolium castaneum]>gi|270001843|gb|EEZ98290.1| hypothetical protein TcasGA2_TC000739 [Tribolium castaneum] -- -- -- -- -- K17918 SNX3_12 sorting nexin-3/12 http://www.genome.jp/dbget-bin/www_bget?ko:K17918 Q9UMY4 597 2.6e-60 Sorting nexin-12 OS=Homo sapiens GN=SNX12 PE=1 SV=3 PF00233//PF00787 3'5'-cyclic nucleotide phosphodiesterase//PX domain GO:0007154//GO:0006144//GO:0007165 cell communication//purine nucleobase metabolic process//signal transduction GO:0035091//GO:0004114 phosphatidylinositol binding//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG2527 Sorting nexin SNX11 Cluster-8309.50588 BP_3 36.15 0.78 2518 91076806 XP_974293.1 777 1.3e-79 PREDICTED: sorting nexin-12 [Tribolium castaneum]>gi|270001843|gb|EEZ98290.1| hypothetical protein TcasGA2_TC000739 [Tribolium castaneum] -- -- -- -- -- K17918 SNX3_12 sorting nexin-3/12 http://www.genome.jp/dbget-bin/www_bget?ko:K17918 Q9UMY4 597 4.0e-60 Sorting nexin-12 OS=Homo sapiens GN=SNX12 PE=1 SV=3 PF00233//PF00787 3'5'-cyclic nucleotide phosphodiesterase//PX domain GO:0006144//GO:0007154//GO:0007165 purine nucleobase metabolic process//cell communication//signal transduction GO:0035091//GO:0004114 phosphatidylinositol binding//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG2527 Sorting nexin SNX11 Cluster-8309.50589 BP_3 78.40 1.74 2459 91076806 XP_974293.1 777 1.3e-79 PREDICTED: sorting nexin-12 [Tribolium castaneum]>gi|270001843|gb|EEZ98290.1| hypothetical protein TcasGA2_TC000739 [Tribolium castaneum] -- -- -- -- -- K17918 SNX3_12 sorting nexin-3/12 http://www.genome.jp/dbget-bin/www_bget?ko:K17918 Q9UMY4 597 3.9e-60 Sorting nexin-12 OS=Homo sapiens GN=SNX12 PE=1 SV=3 PF00233//PF00787 3'5'-cyclic nucleotide phosphodiesterase//PX domain GO:0007154//GO:0006144//GO:0007165 cell communication//purine nucleobase metabolic process//signal transduction GO:0035091//GO:0004114 phosphatidylinositol binding//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG2527 Sorting nexin SNX11 Cluster-8309.50591 BP_3 51.88 1.66 1798 642929939 XP_008196034.1 980 2.7e-103 PREDICTED: nucleolar protein 4-like isoform X2 [Tribolium castaneum] 642929940 XM_008197813.1 280 1.80435e-142 PREDICTED: Tribolium castaneum nucleolar protein 4-like (LOC664605), transcript variant X3, mRNA -- -- -- -- O94818 393 1.3e-36 Nucleolar protein 4 OS=Homo sapiens GN=NOL4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50593 BP_3 157.52 10.24 1033 332374840 AEE62561.1 651 2.2e-65 unknown [Dendroctonus ponderosae]>gi|546685384|gb|ERL94902.1| hypothetical protein D910_12175 [Dendroctonus ponderosae] -- -- -- -- -- K06134 COQ7 ubiquinone biosynthesis monooxygenase Coq7 http://www.genome.jp/dbget-bin/www_bget?ko:K06134 Q99807 459 1.6e-44 5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens GN=COQ7 PE=1 SV=3 PF03232//PF02915 Ubiquinone biosynthesis protein COQ7//Rubrerythrin GO:0055114//GO:0006744 oxidation-reduction process//ubiquinone biosynthetic process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- KOG4061 DMQ mono-oxygenase/Ubiquinone biosynthesis protein COQ7/CLK-1/CAT5 Cluster-8309.50594 BP_3 23.00 1.68 951 641669667 XP_008184906.1 270 3.0e-21 PREDICTED: uncharacterized protein LOC100574215 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50598 BP_3 38.61 0.39 5049 91079074 XP_975225.1 1006 7.3e-106 PREDICTED: ras-related protein Rab-10 [Tribolium castaneum]>gi|270003655|gb|EFA00103.1| hypothetical protein TcasGA2_TC002919 [Tribolium castaneum] 642916371 XM_970132.3 262 5.20205e-132 PREDICTED: Tribolium castaneum ras-related protein Rab-10 (LOC664117), mRNA K07903 RAB10 Ras-related protein Rab-10 http://www.genome.jp/dbget-bin/www_bget?ko:K07903 P22127 812 9.4e-85 Ras-related protein Rab-10 OS=Diplobatis ommata PE=2 SV=1 PF03193//PF00874//PF04344//PF15898//PF00071//PF02601//PF04670//PF04513//PF01442//PF08477//PF04111//PF01926//PF16716//PF00025//PF01496 Protein of unknown function, DUF258//PRD domain//Chemotaxis phosphatase, CheZ//cGMP-dependent protein kinase interacting domain//Ras family//Exonuclease VII, large subunit//Gtr1/RagA G protein conserved region//Baculovirus polyhedron envelope protein, PEP, C terminus//Apolipoprotein A1/A4/E domain//Ras of Complex, Roc, domain of DAPkinase//Autophagy protein Apg6//50S ribosome-binding GTPase//Bone marrow stromal antigen 2//ADP-ribosylation factor family//V-type ATPase 116kDa subunit family GO:0006355//GO:0015031//GO:0015992//GO:0050920//GO:0006914//GO:0007264//GO:0006308//GO:0042157//GO:0015991//GO:0006869//GO:0051607 regulation of transcription, DNA-templated//protein transport//proton transport//regulation of chemotaxis//autophagy//small GTPase mediated signal transduction//DNA catabolic process//lipoprotein metabolic process//ATP hydrolysis coupled proton transport//lipid transport//defense response to virus GO:0015078//GO:0019901//GO:0003924//GO:0005198//GO:0005525//GO:0008289//GO:0003824//GO:0008855 hydrogen ion transmembrane transporter activity//protein kinase binding//GTPase activity//structural molecule activity//GTP binding//lipid binding//catalytic activity//exodeoxyribonuclease VII activity GO:0009288//GO:0009318//GO:0019028//GO:0005576//GO:0033179//GO:0019031 bacterial-type flagellum//exodeoxyribonuclease VII complex//viral capsid//extracellular region//proton-transporting V-type ATPase, V0 domain//viral envelope KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.50599 BP_3 145.22 1.70 4419 91079074 XP_975225.1 987 1.0e-103 PREDICTED: ras-related protein Rab-10 [Tribolium castaneum]>gi|270003655|gb|EFA00103.1| hypothetical protein TcasGA2_TC002919 [Tribolium castaneum] 642916371 XM_970132.3 262 4.5483e-132 PREDICTED: Tribolium castaneum ras-related protein Rab-10 (LOC664117), mRNA K07903 RAB10 Ras-related protein Rab-10 http://www.genome.jp/dbget-bin/www_bget?ko:K07903 P22127 793 1.3e-82 Ras-related protein Rab-10 OS=Diplobatis ommata PE=2 SV=1 PF01442//PF08477//PF04111//PF00025//PF16716//PF01496//PF04344//PF15898//PF00071//PF02601 Apolipoprotein A1/A4/E domain//Ras of Complex, Roc, domain of DAPkinase//Autophagy protein Apg6//ADP-ribosylation factor family//Bone marrow stromal antigen 2//V-type ATPase 116kDa subunit family//Chemotaxis phosphatase, CheZ//cGMP-dependent protein kinase interacting domain//Ras family//Exonuclease VII, large subunit GO:0042157//GO:0051607//GO:0006869//GO:0015991//GO:0007264//GO:0006308//GO:0050920//GO:0006914//GO:0015992//GO:0015031 lipoprotein metabolic process//defense response to virus//lipid transport//ATP hydrolysis coupled proton transport//small GTPase mediated signal transduction//DNA catabolic process//regulation of chemotaxis//autophagy//proton transport//protein transport GO:0003824//GO:0008289//GO:0008855//GO:0005525//GO:0019901//GO:0015078 catalytic activity//lipid binding//exodeoxyribonuclease VII activity//GTP binding//protein kinase binding//hydrogen ion transmembrane transporter activity GO:0005576//GO:0033179//GO:0009318//GO:0009288 extracellular region//proton-transporting V-type ATPase, V0 domain//exodeoxyribonuclease VII complex//bacterial-type flagellum KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.506 BP_3 6.14 0.47 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50600 BP_3 20.45 5.02 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50601 BP_3 91.00 3.25 1642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50603 BP_3 133.16 7.42 1157 642932044 XP_008196835.1 430 1.0e-39 PREDICTED: uncharacterized protein LOC103313971 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50605 BP_3 62.65 0.51 6246 642932046 XP_008196836.1 832 1.4e-85 PREDICTED: uncharacterized protein LOC103313971 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80VL1 160 4.7e-09 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF04277//PF15802 Oxaloacetate decarboxylase, gamma chain//DDB1- and CUL4-associated factor 17 GO:0016567//GO:0006560//GO:0006525//GO:0071436//GO:0006090//GO:0006814 protein ubiquitination//proline metabolic process//arginine metabolic process//sodium ion export//pyruvate metabolic process//sodium ion transport GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.50606 BP_3 51.12 0.40 6491 642932046 XP_008196836.1 832 1.4e-85 PREDICTED: uncharacterized protein LOC103313971 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF15802 Oxaloacetate decarboxylase, gamma chain//DDB1- and CUL4-associated factor 17 GO:0006560//GO:0016567//GO:0006525//GO:0006090//GO:0071436//GO:0006814 proline metabolic process//protein ubiquitination//arginine metabolic process//pyruvate metabolic process//sodium ion export//sodium ion transport GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.50607 BP_3 15.77 0.95 1090 91079146 XP_966535.1 240 1.0e-17 PREDICTED: ankyrin repeat domain-containing protein 49 [Tribolium castaneum]>gi|270004231|gb|EFA00679.1| hypothetical protein TcasGA2_TC003556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VE42 153 5.3e-09 Ankyrin repeat domain-containing protein 49 OS=Mus musculus GN=Ankrd49 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50608 BP_3 1076.96 7.36 7344 642937185 XP_008198729.1 2693 2.6e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 3.94939e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.5e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF00856//PF11744//PF05192//PF00023//PF05033//PF00995//PF13606 SET domain//Aluminium activated malate transporter//MutS domain III//Ankyrin repeat//Pre-SET motif//Sec1 family//Ankyrin repeat GO:0016192//GO:0034968//GO:0015743//GO:0006904//GO:0006298//GO:0006554//GO:0006479 vesicle-mediated transport//histone lysine methylation//malate transport//vesicle docking involved in exocytosis//mismatch repair//lysine catabolic process//protein methylation GO:0005515//GO:0018024//GO:0005524//GO:0030983//GO:0008270 protein binding//histone-lysine N-methyltransferase activity//ATP binding//mismatched DNA binding//zinc ion binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.50610 BP_3 341.19 11.51 1721 189237479 XP_970444.2 1590 4.8e-174 PREDICTED: golgi-associated PDZ and coiled-coil motif-containing protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH60 759 4.5e-79 Golgi-associated PDZ and coiled-coil motif-containing protein OS=Mus musculus GN=Gopc PE=1 SV=1 PF04871//PF05837//PF06156//PF00595 Uso1 / p115 like vesicle tethering protein, C terminal region//Centromere protein H (CENP-H)//Protein of unknown function (DUF972)//PDZ domain (Also known as DHR or GLGF) GO:0051382//GO:0006886//GO:0006260//GO:0015031 kinetochore assembly//intracellular protein transport//DNA replication//protein transport GO:0005515//GO:0008565 protein binding//protein transporter activity GO:0016020//GO:0000776//GO:0005737 membrane//kinetochore//cytoplasm -- -- Cluster-8309.50612 BP_3 80.78 1.09 3864 642911213 XP_008199622.1 1038 1.1e-109 PREDICTED: FCH domain only protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UQN2 622 7.7e-63 F-BAR domain only protein 2 OS=Mus musculus GN=Fcho2 PE=1 SV=1 PF02662//PF01442//PF02050//PF13326 Methyl-viologen-reducing hydrogenase, delta subunit//Apolipoprotein A1/A4/E domain//Flagellar FliJ protein//Photosystem II Pbs27 GO:0055114//GO:0010207//GO:0071973//GO:0006869//GO:0006935//GO:0042157//GO:0015948 oxidation-reduction process//photosystem II assembly//bacterial-type flagellum-dependent cell motility//lipid transport//chemotaxis//lipoprotein metabolic process//methanogenesis GO:0003774//GO:0008289 motor activity//lipid binding GO:0016020//GO:0009288//GO:0005576 membrane//bacterial-type flagellum//extracellular region KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.50613 BP_3 82.82 2.00 2284 642923805 XP_008193890.1 1839 8.5e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 4.5e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.50615 BP_3 34.61 0.40 4504 91082023 XP_970243.1 884 9.1e-92 PREDICTED: 39S ribosomal protein L47, mitochondrial [Tribolium castaneum]>gi|270007306|gb|EFA03754.1| hypothetical protein TcasGA2_TC013863 [Tribolium castaneum] -- -- -- -- -- K17428 MRPL47, NCM1 large subunit ribosomal protein L47 http://www.genome.jp/dbget-bin/www_bget?ko:K17428 Q9HD33 443 5.2e-42 39S ribosomal protein L47, mitochondrial OS=Homo sapiens GN=MRPL47 PE=1 SV=2 PF06984 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0005761 ribosome//mitochondrial ribosome KOG3331 Mitochondrial/chloroplast ribosomal protein L4/L29 Cluster-8309.5062 BP_3 3.00 0.45 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50620 BP_3 107.06 2.40 2443 270012313 EFA08761.1 390 9.5e-35 hypothetical protein TcasGA2_TC006440 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q93373 201 3.2e-14 Leucine-rich repeat-containing protein let-4 OS=Caenorhabditis elegans GN=let-4 PE=2 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.50624 BP_3 25.95 0.42 3303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50625 BP_3 160.25 0.87 9216 270010529 EFA06977.1 4691 0.0e+00 hypothetical protein TcasGA2_TC009937 [Tribolium castaneum] 642929421 XM_008197611.1 179 1.31275e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA -- -- -- -- Q9UIF8 496 7.5e-48 Bromodomain adjacent to zinc finger domain protein 2B OS=Homo sapiens GN=BAZ2B PE=1 SV=3 PF01429//PF01221//PF00439//PF00130//PF08926//PF04574//PF06638//PF00628//PF16866 Methyl-CpG binding domain//Dynein light chain type 1//Bromodomain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Domain of unknown function (DUF1908)//Protein of unknown function (DUF592)//Strabismus protein//PHD-finger//PHD-finger GO:0006468//GO:0009069//GO:0035556//GO:0007017//GO:0006355//GO:0016310//GO:0006476//GO:0007275//GO:0006342//GO:0006807 protein phosphorylation//serine family amino acid metabolic process//intracellular signal transduction//microtubule-based process//regulation of transcription, DNA-templated//phosphorylation//protein deacetylation//multicellular organismal development//chromatin silencing//nitrogen compound metabolic process GO:0017136//GO:0016811//GO:0005524//GO:0004674//GO:0008270//GO:0005515//GO:0051287//GO:0003677//GO:0000287 NAD-dependent histone deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//ATP binding//protein serine/threonine kinase activity//zinc ion binding//protein binding//NAD binding//DNA binding//magnesium ion binding GO:0005875//GO:0016021//GO:0005634//GO:0000118 microtubule associated complex//integral component of membrane//nucleus//histone deacetylase complex KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.50626 BP_3 751.39 21.28 1994 332374338 AEE62310.1 903 2.5e-94 unknown [Dendroctonus ponderosae] 759034475 XM_011335706.1 148 4.7918e-69 PREDICTED: Cerapachys biroi ADP-ribosylation factor-like protein 5B (LOC105277374), mRNA K07950 ARL5B ADP-ribosylation factor-like protein 5B http://www.genome.jp/dbget-bin/www_bget?ko:K07950 Q2KJ96 746 1.7e-77 ADP-ribosylation factor-like protein 5A OS=Bos taurus GN=ARL5A PE=2 SV=1 PF00071//PF04670//PF00503//PF01926//PF08477//PF03661//PF02421//PF00025//PF05843 Ras family//Gtr1/RagA G protein conserved region//G-protein alpha subunit//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Uncharacterised protein family (UPF0121)//Ferrous iron transport protein B//ADP-ribosylation factor family//Suppressor of forked protein (Suf) GO:0007186//GO:0007264//GO:0015684//GO:0007165//GO:0006397 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//ferrous iron transport//signal transduction//mRNA processing GO:0005525//GO:0019001//GO:0004871//GO:0015093//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//ferrous iron transmembrane transporter activity//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.50628 BP_3 9.98 1.25 675 91087535 XP_970133.1 629 5.1e-63 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] 642930219 XM_965040.2 161 9.30676e-77 PREDICTED: Tribolium castaneum DNA-directed RNA polymerases I, II, and III subunit RPABC3 (LOC658676), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 440 1.7e-42 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.50630 BP_3 64.89 1.29 2709 91088147 XP_971356.1 1157 1.2e-123 PREDICTED: platelet-activating factor acetylhydrolase [Tribolium castaneum]>gi|270012120|gb|EFA08568.1| hypothetical protein TcasGA2_TC006223 [Tribolium castaneum] -- -- -- -- -- K05961 dnk deoxynucleoside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05961 P70683 520 3.6e-51 Platelet-activating factor acetylhydrolase OS=Cavia porcellus GN=PLA2G7 PE=2 SV=1 PF03403//PF01121//PF02367//PF01738//PF00005 Platelet-activating factor acetylhydrolase, isoform II//Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Dienelactone hydrolase family//ABC transporter GO:0046486//GO:0015937//GO:0016042//GO:0002949//GO:0015940 glycerolipid metabolic process//coenzyme A biosynthetic process//lipid catabolic process//tRNA threonylcarbamoyladenosine modification//pantothenate biosynthetic process GO:0004140//GO:0016887//GO:0016787//GO:0003847//GO:0005524 dephospho-CoA kinase activity//ATPase activity//hydrolase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//ATP binding GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4235 Mitochondrial thymidine kinase 2/deoxyguanosine kinase Cluster-8309.50631 BP_3 265.67 1.44 9206 642937449 XP_008198840.1 454 1.4e-41 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127//PF00628//PF00042 Late nodulin protein//PHD-finger//Globin GO:0009878 nodule morphogenesis GO:0019825//GO:0020037//GO:0046872//GO:0005515 oxygen binding//heme binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.50633 BP_3 36.40 1.20 1757 478255456 ENN75677.1 422 1.3e-38 hypothetical protein YQE_07775, partial [Dendroctonus ponderosae] 662202247 XM_008476190.1 51 3.51966e-15 PREDICTED: Diaphorina citri WW domain-binding protein 4-like (LOC103511468), mRNA K13220 WBP4, FBP21 WW domain-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13220 Q5HZF2 177 1.4e-11 WW domain-binding protein 4 OS=Rattus norvegicus GN=Wbp4 PE=2 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0150 Spliceosomal protein FBP21 Cluster-8309.50636 BP_3 1563.00 24.00 3431 546674943 ERL86220.1 2362 2.9e-263 hypothetical protein D910_03631, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZVD7 317 1.6e-27 Storkhead-box protein 1 OS=Homo sapiens GN=STOX1 PE=1 SV=2 PF02153 Prephenate dehydrogenase GO:0006571//GO:0055114//GO:0000162//GO:0009094 tyrosine biosynthetic process//oxidation-reduction process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process GO:0008977//GO:0004665 prephenate dehydrogenase activity//prephenate dehydrogenase (NADP+) activity -- -- -- -- Cluster-8309.50637 BP_3 1161.19 10.61 5569 91080879 XP_972622.1 4552 0.0e+00 PREDICTED: coronin-7 isoform X2 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1118 3.4e-120 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.50638 BP_3 126.49 3.93 1844 270002221 EEZ98668.1 1684 6.4e-185 hypothetical protein TcasGA2_TC001200 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91V83 593 8.5e-60 TELO2-interacting protein 1 homolog OS=Mus musculus GN=Tti1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4524 Uncharacterized conserved protein Cluster-8309.50639 BP_3 72.81 4.38 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5064 BP_3 19.09 0.51 2108 642910346 XP_970887.2 1984 1.2e-219 PREDICTED: serine/threonine-protein kinase MAK isoform X2 [Tribolium castaneum] 689931499 LM413849.1 50 1.52392e-14 Enterobius vermicularis genome assembly E_vermicularis_Canary_Islands ,scaffold EVEC_scaffold0000298 K08829 MAK male germ cell-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08829 P20793 1138 6.2e-123 Serine/threonine-protein kinase MAK OS=Rattus norvegicus GN=Mak PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0661 MAPK related serine/threonine protein kinase Cluster-8309.50640 BP_3 215.76 2.24 4930 676425900 XP_009044451.1 383 1.2e-33 hypothetical protein LOTGIDRAFT_156185 [Lottia gigantea]>gi|556116290|gb|ESP04942.1| hypothetical protein LOTGIDRAFT_156185 [Lottia gigantea] -- -- -- -- -- -- -- -- -- Q9CXE0 370 1.6e-33 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF07776//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.50645 BP_3 376.73 3.30 5790 642920442 XP_008192352.1 1913 5.6e-211 PREDICTED: interference hedgehog-like isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 849 5.5e-89 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF13895//PF00041//PF02480//PF16656 Immunoglobulin domain//Fibronectin type III domain//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity GO:0016020 membrane -- -- Cluster-8309.50646 BP_3 2.08 0.47 507 642915775 XP_008200074.1 399 1.8e-36 PREDICTED: translocating chain-associated membrane protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14010 TRAM1 translocating chain-associated membrane protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14010 Q01685 170 2.6e-11 Translocating chain-associated membrane protein 1 OS=Canis familiaris GN=TRAM1 PE=1 SV=2 PF03798 TLC domain -- -- -- -- GO:0016021 integral component of membrane KOG1608 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.50650 BP_3 33.19 0.72 2507 91084211 XP_968214.1 800 2.8e-82 PREDICTED: transcriptional adapter 3 [Tribolium castaneum]>gi|270008765|gb|EFA05213.1| hypothetical protein TcasGA2_TC015353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66IZ5 313 3.4e-27 Transcriptional adapter 3-B OS=Xenopus laevis GN=tada3-b PE=2 SV=1 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.50652 BP_3 105.80 2.32 2486 780089478 XP_011673857.1 145 2.5e-06 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10104//PF02935 Di-sulfide bridge nucleocytoplasmic transport domain//Cytochrome c oxidase subunit VIIc GO:0006406//GO:0006611//GO:0006998//GO:0006123//GO:0015992 mRNA export from nucleus//protein export from nucleus//nuclear envelope organization//mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0031965//GO:0045277 nuclear membrane//respiratory chain complex IV -- -- Cluster-8309.50653 BP_3 71.12 3.60 1244 478250793 ENN71285.1 367 2.2e-32 hypothetical protein YQE_12210, partial [Dendroctonus ponderosae] -- -- -- -- -- K17402 MRPS23 small subunit ribosomal protein S23 http://www.genome.jp/dbget-bin/www_bget?ko:K17402 Q2NL27 174 2.2e-11 28S ribosomal protein S23, mitochondrial OS=Bos taurus GN=MRPS23 PE=1 SV=1 PF10484//PF13741 Mitochondrial ribosomal protein S23//Mitochondrial ribosomal protein S25 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005763//GO:0005840 mitochondrial small ribosomal subunit//ribosome -- -- Cluster-8309.50654 BP_3 207.35 10.74 1222 546673007 ERL84693.1 367 2.2e-32 hypothetical protein D910_02120 [Dendroctonus ponderosae] -- -- -- -- -- K17402 MRPS23 small subunit ribosomal protein S23 http://www.genome.jp/dbget-bin/www_bget?ko:K17402 Q2NL27 174 2.2e-11 28S ribosomal protein S23, mitochondrial OS=Bos taurus GN=MRPS23 PE=1 SV=1 PF10484//PF13741 Mitochondrial ribosomal protein S23//Mitochondrial ribosomal protein S25 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005763 ribosome//mitochondrial small ribosomal subunit -- -- Cluster-8309.50655 BP_3 38.65 0.88 2409 91081955 XP_967420.1 2232 2.4e-248 PREDICTED: cullin-3 [Tribolium castaneum]>gi|270007361|gb|EFA03809.1| hypothetical protein TcasGA2_TC013922 [Tribolium castaneum] 755982854 XM_011311736.1 300 1.85187e-153 PREDICTED: Fopius arisanus cullin-3 (LOC105270650), mRNA K03869 CUL3 cullin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03869 B5DF89 1843 1.3e-204 Cullin-3 OS=Rattus norvegicus GN=Cul3 PE=1 SV=2 PF02023//PF12422//PF00888 SCAN domain//Condensin II non structural maintenance of chromosomes subunit//Cullin family GO:0006511//GO:0006355 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0031625 transcription factor activity, sequence-specific DNA binding//ubiquitin protein ligase binding GO:0005667//GO:0005634//GO:0031461 transcription factor complex//nucleus//cullin-RING ubiquitin ligase complex KOG2166 Cullins Cluster-8309.50656 BP_3 3.71 1.39 420 642925982 XP_968141.3 535 2.5e-52 PREDICTED: sugar phosphate exchanger 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 P57057 368 2.4e-34 Glycerol-3-phosphate transporter OS=Homo sapiens GN=SLC37A1 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.50657 BP_3 426.28 4.19 5197 283046724 NP_001164308.1 351 6.7e-30 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 275 1.8e-22 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF13606//PF09153//PF04988//PF00096//PF00520//PF07535 Ankyrin repeat//Domain of unknown function (DUF1938)//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Ion transport protein//DBF zinc finger GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0003676//GO:0008270//GO:0005216//GO:0046872//GO:0003677//GO:0005515 nucleic acid binding//zinc ion binding//ion channel activity//metal ion binding//DNA binding//protein binding GO:0016020//GO:0005737//GO:0005634 membrane//cytoplasm//nucleus -- -- Cluster-8309.50662 BP_3 28.50 1.05 1606 478257137 ENN77300.1 376 2.6e-33 hypothetical protein YQE_06126, partial [Dendroctonus ponderosae]>gi|546681456|gb|ERL91553.1| hypothetical protein D910_08883 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50663 BP_3 35.55 0.88 2234 91077894 XP_973141.1 1014 3.8e-107 PREDICTED: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [Tribolium castaneum]>gi|270001465|gb|EEZ97912.1| hypothetical protein TcasGA2_TC000297 [Tribolium castaneum] 704568790 XM_010186488.1 35 3.52406e-06 PREDICTED: Mesitornis unicolor farnesyltransferase, CAAX box, alpha (FNTA), partial mRNA K05955 FNTA protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05955 P29702 623 3.4e-63 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Bos taurus GN=FNTA PE=2 SV=2 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- KOG0530 Protein farnesyltransferase, alpha subunit/protein geranylgeranyltransferase type I, alpha subunit Cluster-8309.50666 BP_3 52.38 0.84 3295 642934163 XP_008199633.1 735 1.3e-74 PREDICTED: uncharacterized protein LOC657295 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14135 151 2.7e-08 Transcription cofactor vestigial-like protein 4 OS=Homo sapiens GN=VGLL4 PE=1 SV=4 PF07545//PF15245 Vestigial/Tondu family//Transcription cofactor vestigial-like protein 4 GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.50670 BP_3 2424.57 71.29 1931 642920402 XP_008192333.1 464 2.0e-43 PREDICTED: uncharacterized protein LOC664268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50671 BP_3 564.67 8.26 3585 546676365 ERL87392.1 1940 2.6e-214 hypothetical protein D910_04787, partial [Dendroctonus ponderosae] 828210619 XM_004208630.2 127 4.09515e-57 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 1339 5.2e-146 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF09573//PF06293//PF00069//PF07714 TaqI restriction endonuclease//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006308//GO:0009307//GO:0006468 DNA catabolic process//DNA restriction-modification system//protein phosphorylation GO:0004672//GO:0016773//GO:0009036//GO:0003677//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//Type II site-specific deoxyribonuclease activity//DNA binding//ATP binding GO:0016020//GO:0009359 membrane//Type II site-specific deoxyribonuclease complex KOG4717 Serine/threonine protein kinase Cluster-8309.50673 BP_3 34.18 0.44 4011 91075990 XP_970704.1 2425 1.7e-270 PREDICTED: synaptojanin-1 isoform X1 [Tribolium castaneum]>gi|270014666|gb|EFA11114.1| hypothetical protein TcasGA2_TC004712 [Tribolium castaneum] 642910454 XM_008192523.1 287 5.22385e-146 PREDICTED: Tribolium castaneum synaptojanin-1 (LOC659292), transcript variant X2, mRNA K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 O43426 1532 2.4e-168 Synaptojanin-1 OS=Homo sapiens GN=SYNJ1 PE=1 SV=2 -- -- GO:0046854 phosphatidylinositol phosphorylation GO:0042578//GO:0000166 phosphoric ester hydrolase activity//nucleotide binding -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.50674 BP_3 314.06 3.15 5100 270012402 EFA08850.1 3240 0.0e+00 hypothetical protein TcasGA2_TC006551 [Tribolium castaneum] 642932661 XM_008198715.1 84 4.67978e-33 PREDICTED: Tribolium castaneum inactive rhomboid protein 1 (LOC658816), mRNA -- -- -- -- Q76NQ1 1377 2.9e-150 Inactive rhomboid protein 1 OS=Drosophila melanogaster GN=rho-5 PE=2 SV=1 PF01694 Rhomboid family -- -- GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2290 Rhomboid family proteins Cluster-8309.50675 BP_3 255.44 2.41 5397 642919693 XP_008192024.1 793 3.9e-81 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 372 1.1e-33 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF10716//PF00520 NADH dehydrogenase transmembrane subunit//Ion transport protein GO:0055114//GO:0006811//GO:0006118//GO:0055085 oxidation-reduction process//ion transport//obsolete electron transport//transmembrane transport GO:0016655//GO:0005216 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//ion channel activity GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.50676 BP_3 2.10 0.88 405 827552646 XP_012548082.1 397 2.4e-36 PREDICTED: LOW QUALITY PROTEIN: p270 isoform X1 [Bombyx mori] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 347 6.2e-32 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.50677 BP_3 122.21 0.80 7643 642937579 XP_008199106.1 1348 2.4e-145 PREDICTED: protein bric-a-brac 1-like isoform X1 [Tribolium castaneum]>gi|270001234|gb|EEZ97681.1| hypothetical protein TcasGA2_TC016226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B87 360 3.7e-32 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF03938//PF10473//PF05485//PF00651//PF04871//PF13851//PF00644 Outer membrane protein (OmpH-like)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//THAP domain//BTB/POZ domain//Uso1 / p115 like vesicle tethering protein, C terminal region//Growth-arrest specific micro-tubule binding//Poly(ADP-ribose) polymerase catalytic domain GO:0015031//GO:0006886//GO:0048870 protein transport//intracellular protein transport//cell motility GO:0008565//GO:0051082//GO:0045502//GO:0008134//GO:0003676//GO:0042803//GO:0003950//GO:0005515 protein transporter activity//unfolded protein binding//dynein binding//transcription factor binding//nucleic acid binding//protein homodimerization activity//NAD+ ADP-ribosyltransferase activity//protein binding GO:0005737//GO:0031514//GO:0016020//GO:0030286//GO:0005667 cytoplasm//motile cilium//membrane//dynein complex//transcription factor complex -- -- Cluster-8309.50678 BP_3 40.56 1.09 2093 478254477 ENN74726.1 1349 5.1e-146 hypothetical protein YQE_08693, partial [Dendroctonus ponderosae]>gi|546685047|gb|ERL94601.1| hypothetical protein D910_11878 [Dendroctonus ponderosae] -- -- -- -- -- K13205 AAR2, C20orf4 A1 cistron-splicing factor AAR2 http://www.genome.jp/dbget-bin/www_bget?ko:K13205 Q08DJ7 779 2.6e-81 Protein AAR2 homolog OS=Bos taurus GN=AAR2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3937 mRNA splicing factor Cluster-8309.50679 BP_3 11.46 1.93 578 642926187 XP_008194822.1 484 2.8e-46 PREDICTED: deleted in azoospermia-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24207 333 3.8e-30 Protein boule OS=Drosophila melanogaster GN=bol PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.50682 BP_3 36.74 0.81 2476 642939406 XP_008193285.1 335 2.3e-28 PREDICTED: uncharacterized protein LOC661130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M8X6 130 5.6e-06 Collectin-10 OS=Xenopus tropicalis GN=colec10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50683 BP_3 40.12 0.54 3862 795015467 XP_011858161.1 354 2.2e-30 PREDICTED: uncharacterized protein LOC105555728, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q5M8X6 130 8.7e-06 Collectin-10 OS=Xenopus tropicalis GN=colec10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50684 BP_3 39.46 0.78 2725 642937777 XP_008198941.1 1118 4.1e-119 PREDICTED: probable phospholipid-transporting ATPase IM isoform X3 [Tribolium castaneum] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 Q8TF62 561 6.5e-56 Probable phospholipid-transporting ATPase IM OS=Homo sapiens GN=ATP8B4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0206 P-type ATPase Cluster-8309.50685 BP_3 301.00 7.06 2348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50687 BP_3 26.59 0.52 2734 189241298 XP_975145.2 1031 5.0e-109 PREDICTED: cyclin-dependent kinase 12 isoform X1 [Tribolium castaneum] 675419157 XM_008924738.1 53 4.26166e-16 PREDICTED: Manacus vitellinus cyclin-dependent kinase 12 (CDK12), mRNA K08819 CDK12_13 cyclin-dependent kinase 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K08819 Q9VP22 883 3.0e-93 Cyclin-dependent kinase 12 OS=Drosophila melanogaster GN=Cdk12 PE=1 SV=1 PF00069//PF03092 Protein kinase domain//BT1 family GO:0006468//GO:0006810 protein phosphorylation//transport GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0016021 integral component of membrane KOG0600 Cdc2-related protein kinase Cluster-8309.50688 BP_3 1.00 2.12 294 478253101 ENN73474.1 247 4.3e-19 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02161 Progesterone receptor GO:0006355//GO:0007165//GO:0043401 regulation of transcription, DNA-templated//signal transduction//steroid hormone mediated signaling pathway GO:0003707//GO:0005496//GO:0003677 steroid hormone receptor activity//steroid binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.50692 BP_3 24.38 0.98 1493 270012966 EFA09414.1 151 3.0e-07 hypothetical protein TcasGA2_TC005216 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50693 BP_3 2.00 1.63 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50695 BP_3 36.00 2.88 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50698 BP_3 4.00 5.83 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50699 BP_3 18.00 2.77 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50700 BP_3 37.25 0.35 5367 478255001 ENN75234.1 1692 2.2e-185 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1080 8.4e-116 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF06414//PF01637//PF03193//PF00005//PF01926//PF13304//PF00664//PF00437 Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0016301//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50701 BP_3 340.32 3.98 4414 642938610 XP_008199864.1 2111 4.7e-234 PREDICTED: protein trachealess [Tribolium castaneum] 820805579 KP147944.1 547 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1103 1.5e-118 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF00010//PF04551//PF08447//PF00989 Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold//PAS fold GO:0055114//GO:0016114//GO:0006355 oxidation-reduction process//terpenoid biosynthetic process//regulation of transcription, DNA-templated GO:0005515//GO:0046429//GO:0046983 protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//protein dimerization activity -- -- -- -- Cluster-8309.50704 BP_3 476.20 15.17 1805 546682401 ERL92343.1 1126 3.2e-120 hypothetical protein D910_09660 [Dendroctonus ponderosae] -- -- -- -- -- K14648 ENDOU, PP11 poly(U)-specific endoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K14648 Q9VZ49 735 2.9e-76 Poly(U)-specific endoribonuclease homolog OS=Drosophila melanogaster GN=CG2145 PE=1 SV=1 PF09412 Endoribonuclease XendoU -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2849 Placental protein 11 Cluster-8309.50705 BP_3 36.86 0.71 2802 478257079 ENN77242.1 1174 1.3e-125 hypothetical protein YQE_06072, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.50709 BP_3 175.00 5.99 1701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50710 BP_3 42.08 1.69 1493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.50715 BP_3 29.42 0.82 2018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50718 BP_3 251.55 2.91 4465 91082023 XP_970243.1 884 9.1e-92 PREDICTED: 39S ribosomal protein L47, mitochondrial [Tribolium castaneum]>gi|270007306|gb|EFA03754.1| hypothetical protein TcasGA2_TC013863 [Tribolium castaneum] -- -- -- -- -- K17428 MRPL47, NCM1 large subunit ribosomal protein L47 http://www.genome.jp/dbget-bin/www_bget?ko:K17428 Q9HD33 443 5.1e-42 39S ribosomal protein L47, mitochondrial OS=Homo sapiens GN=MRPL47 PE=1 SV=2 PF06984 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0005761 ribosome//mitochondrial ribosome KOG3331 Mitochondrial/chloroplast ribosomal protein L4/L29 Cluster-8309.50719 BP_3 100.19 1.09 4722 91082023 XP_970243.1 884 9.6e-92 PREDICTED: 39S ribosomal protein L47, mitochondrial [Tribolium castaneum]>gi|270007306|gb|EFA03754.1| hypothetical protein TcasGA2_TC013863 [Tribolium castaneum] -- -- -- -- -- K17428 MRPL47, NCM1 large subunit ribosomal protein L47 http://www.genome.jp/dbget-bin/www_bget?ko:K17428 Q9HD33 443 5.4e-42 39S ribosomal protein L47, mitochondrial OS=Homo sapiens GN=MRPL47 PE=1 SV=2 PF06984 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005761//GO:0005840 mitochondrial ribosome//ribosome KOG3331 Mitochondrial/chloroplast ribosomal protein L4/L29 Cluster-8309.50720 BP_3 1841.86 20.57 4607 91081241 XP_975643.1 2015 6.7e-223 PREDICTED: interference hedgehog-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 851 2.6e-89 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF02480//PF16656//PF00041//PF13895 Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.50724 BP_3 30.00 5.03 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50729 BP_3 2.90 0.33 713 166851830 NP_001107779.1 662 8.0e-67 bursicon precursor [Tribolium castaneum]>gi|74325216|gb|ABA03053.1| bursicon [Tribolium castaneum]>gi|270008186|gb|EFA04634.1| bursicon [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VD83 549 4.2e-55 Bursicon OS=Drosophila melanogaster GN=Burs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50730 BP_3 2634.33 32.12 4245 642923551 XP_008193555.1 837 2.4e-86 PREDICTED: Golgi integral membrane protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49638 186 3.1e-12 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 PF01940//PF02513//PF04111//PF02566//PF05090 Integral membrane protein DUF92//Spin/Ssty Family//Autophagy protein Apg6//OsmC-like protein//Vitamin K-dependent gamma-carboxylase GO:0006914//GO:0007276//GO:0017187//GO:0006979 autophagy//gamete generation//peptidyl-glutamic acid carboxylation//response to oxidative stress GO:0008488 gamma-glutamyl carboxylase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50732 BP_3 4.00 0.40 773 817083080 XP_012264132.1 175 2.6e-10 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Athalia rosae] -- -- -- -- -- -- -- -- -- Q3UTY6 140 1.2e-07 Thrombospondin type-1 domain-containing protein 4 OS=Mus musculus GN=Thsd4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50733 BP_3 24.00 1.97 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50734 BP_3 19.61 0.31 3345 91088343 XP_971105.1 804 1.3e-82 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 582 2.9e-58 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF01370//PF02558//PF02254//PF02826//PF02882//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA//TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0006813//GO:0009396//GO:0046487//GO:0008152//GO:0015940 oxidation-reduction process//potassium ion transport//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//metabolic process//pantothenate biosynthetic process GO:0008677//GO:0051287//GO:0016491//GO:0004488//GO:0003824//GO:0050662 2-dehydropantoate 2-reductase activity//NAD binding//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//coenzyme binding -- -- KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.50738 BP_3 349.75 7.12 2660 642914962 XP_008190460.1 841 5.2e-87 PREDICTED: ribosomal RNA-processing protein 8 [Tribolium castaneum]>gi|270001380|gb|EEZ97827.1| hypothetical protein TcasGA2_TC000195 [Tribolium castaneum] -- -- -- -- -- K14850 RRP8 ribosomal RNA-processing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14850 Q9DB85 599 2.5e-60 Ribosomal RNA-processing protein 8 OS=Mus musculus GN=Rrp8 PE=1 SV=1 PF10391//PF05148//PF08241//PF05175 Fingers domain of DNA polymerase lambda//Hypothetical methyltransferase//Methyltransferase domain//Methyltransferase small domain GO:0008152 metabolic process GO:0034061//GO:0008168//GO:0003677 DNA polymerase activity//methyltransferase activity//DNA binding GO:0005634 nucleus KOG3045 Predicted RNA methylase involved in rRNA processing Cluster-8309.50739 BP_3 170.00 6.23 1608 91077596 XP_973387.1 648 7.6e-65 PREDICTED: forkhead-associated domain-containing protein 1 [Tribolium castaneum]>gi|270001561|gb|EEZ98008.1| hypothetical protein TcasGA2_TC000407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16331//PF00992//PF16326//PF05531//PF00170//PF13851//PF06005//PF01166//PF04513//PF03999//PF07716//PF00038//PF02183 TolA binding protein trimerisation//Troponin//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//bZIP transcription factor//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//TSC-22/dip/bun family//Baculovirus polyhedron envelope protein, PEP, C terminus//Microtubule associated protein (MAP65/ASE1 family)//Basic region leucine zipper//Intermediate filament protein//Homeobox associated leucine zipper GO:0006355//GO:0070206//GO:0000226//GO:0043093//GO:0000917//GO:0048870//GO:0000910 regulation of transcription, DNA-templated//protein trimerization//microtubule cytoskeleton organization//FtsZ-dependent cytokinesis//barrier septum assembly//cell motility//cytokinesis GO:0003700//GO:0043565//GO:0005198//GO:0008017//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//structural molecule activity//microtubule binding//DNA binding GO:0005737//GO:0005882//GO:0045298//GO:0019028//GO:0031514//GO:0005861//GO:0019031//GO:0005667 cytoplasm//intermediate filament//tubulin complex//viral capsid//motile cilium//troponin complex//viral envelope//transcription factor complex -- -- Cluster-8309.5074 BP_3 92.88 3.12 1726 4868339 AAD31269.1 643 3.1e-64 trypsinogen RdoT3 precursor [Rhyzopertha dominica] -- -- -- -- -- K09640 TMPRSS9 transmembrane protease, serine 9 http://www.genome.jp/dbget-bin/www_bget?ko:K09640 P35041 567 8.3e-57 Trypsin-7 OS=Anopheles gambiae GN=TRYP7 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.50740 BP_3 145.25 1.53 4862 91093829 XP_969227.1 1839 1.8e-202 PREDICTED: transmembrane protein 161B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C2L6 1009 1.3e-107 Transmembrane protein 161B OS=Mus musculus GN=Tmem161b PE=2 SV=1 PF04632//PF10018//PF01008//PF00336 Fusaric acid resistance protein family//Vitamin-D-receptor interacting Mediator subunit 4//Initiation factor 2 subunit family//DNA polymerase (viral) C-terminal domain GO:0006357//GO:0051252//GO:0006810//GO:0044237 regulation of transcription from RNA polymerase II promoter//regulation of RNA metabolic process//transport//cellular metabolic process GO:0004523//GO:0001104 RNA-DNA hybrid ribonuclease activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005886 mediator complex//plasma membrane KOG1468 Predicted translation initiation factor related to eIF-2B alpha/beta/delta subunits (CIG2/IDI2) Cluster-8309.50741 BP_3 531.05 3.01 8805 91086935 XP_972534.1 3985 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2479 8.2e-278 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13958//PF01926//PF13304//PF00664//PF14719//PF00437//PF03193//PF00005//PF05209//PF02724//PF00640//PF00931 Toxin ToxN, type III toxin-antitoxin system//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Phosphotyrosine interaction domain (PTB/PID)//Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter//Septum formation inhibitor MinC, N-terminal domain//CDC45-like protein//Phosphotyrosine interaction domain (PTB/PID)//NB-ARC domain GO:0055085//GO:0051302//GO:0006810//GO:0006270//GO:0009987//GO:0051252 transmembrane transport//regulation of cell division//transport//DNA replication initiation//cellular process//regulation of RNA metabolic process GO:0005524//GO:0004521//GO:0003924//GO:0016887//GO:0000166//GO:0042626//GO:0003723//GO:0005515//GO:0043531//GO:0005525 ATP binding//endoribonuclease activity//GTPase activity//ATPase activity//nucleotide binding//ATPase activity, coupled to transmembrane movement of substances//RNA binding//protein binding//ADP binding//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.50742 BP_3 1090.11 13.83 4092 91086935 XP_972534.1 4084 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] 195484314 XM_002090606.1 45 1.79395e-11 Drosophila yakuba GE13220 (Dyak\GE13220), partial mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2458 1.0e-275 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF13304//PF01926//PF00437//PF05209//PF00005//PF03193//PF02724//PF00931 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein//Septum formation inhibitor MinC, N-terminal domain//ABC transporter//Protein of unknown function, DUF258//CDC45-like protein//NB-ARC domain GO:0009987//GO:0006270//GO:0006810//GO:0055085//GO:0051302 cellular process//DNA replication initiation//transport//transmembrane transport//regulation of cell division GO:0042626//GO:0000166//GO:0005525//GO:0016887//GO:0043531//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//nucleotide binding//GTP binding//ATPase activity//ADP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.50743 BP_3 7.99 0.31 1533 642920657 XP_008192507.1 905 1.1e-94 PREDICTED: tetratricopeptide repeat protein 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E7F211 504 1.5e-49 Tetratricopeptide repeat protein 17 OS=Danio rerio GN=ttc17 PE=3 SV=1 PF13181//PF02468//PF13174//PF00515//PF13374//PF13371//PF13414//PF13176 Tetratricopeptide repeat//Photosystem II reaction centre N protein (psbN)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0015979 photosynthesis GO:0005515 protein binding GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane KOG4507 Uncharacterized conserved protein, contains TPR repeats Cluster-8309.50745 BP_3 143.03 3.59 2212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50747 BP_3 151.80 0.43 17491 642913486 XP_008201031.1 6210 0.0e+00 PREDICTED: histone-lysine N-methyltransferase 2C-like isoform X2 [Tribolium castaneum] 807039419 XM_004534701.2 145 1.98434e-66 PREDICTED: Ceratitis capitata histone-lysine N-methyltransferase trr (LOC101450744), mRNA K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8IRW8 1972 1.0e-218 Histone-lysine N-methyltransferase trr OS=Drosophila melanogaster GN=trr PE=1 SV=2 PF07155//PF00628//PF05964//PF00856//PF05965//PF08052 ECF-type riboflavin transporter, S component//PHD-finger//F/Y-rich N-terminus//SET domain//F/Y rich C-terminus//PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process GO:0005515 protein binding GO:0016020//GO:0005634 membrane//nucleus KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8309.50749 BP_3 97.17 1.12 4468 642935794 XP_008198177.1 369 4.7e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00864//PF00335 ATP P2X receptor//Tetraspanin family GO:0007165//GO:0006812//GO:0098655//GO:0033198 signal transduction//cation transport//cation transmembrane transport//response to ATP GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.5075 BP_3 192.58 8.31 1409 4868339 AAD31269.1 643 2.5e-64 trypsinogen RdoT3 precursor [Rhyzopertha dominica] -- -- -- -- -- K09640 TMPRSS9 transmembrane protease, serine 9 http://www.genome.jp/dbget-bin/www_bget?ko:K09640 P35041 566 8.8e-57 Trypsin-7 OS=Anopheles gambiae GN=TRYP7 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.50750 BP_3 79.93 1.03 4049 91086367 XP_974595.1 889 2.2e-92 PREDICTED: ankyrin repeat family A protein 2-like [Tribolium castaneum] -- -- -- -- -- K13352 PEX11B peroxin-11B http://www.genome.jp/dbget-bin/www_bget?ko:K13352 Q9ULH0 194 3.5e-13 Kinase D-interacting substrate of 220 kDa OS=Homo sapiens GN=KIDINS220 PE=1 SV=3 PF05648//PF02932//PF00023//PF02931//PF13606 Peroxisomal biogenesis factor 11 (PEX11)//Neurotransmitter-gated ion-channel transmembrane region//Ankyrin repeat//Neurotransmitter-gated ion-channel ligand binding domain//Ankyrin repeat GO:0006811//GO:0016559//GO:0006810 ion transport//peroxisome fission//transport GO:0005230//GO:0005515 extracellular ligand-gated ion channel activity//protein binding GO:0016020//GO:0005779 membrane//integral component of peroxisomal membrane -- -- Cluster-8309.50751 BP_3 135.21 0.85 7986 91079606 XP_966371.1 1460 2.6e-158 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|642917676|ref|XP_008191323.1| PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270003388|gb|EEZ99835.1| hypothetical protein TcasGA2_TC002616 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 585 3.1e-58 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 PF14659//PF16588//PF01312 Phage integrase, N-terminal SAM-like domain//C2H2 zinc-finger//FlhB HrpN YscU SpaS Family GO:0015074//GO:0009306 DNA integration//protein secretion GO:0003676//GO:0003677//GO:0008270 nucleic acid binding//DNA binding//zinc ion binding GO:0016020 membrane KOG1304 Amino acid transporters Cluster-8309.50755 BP_3 76.88 1.45 2844 642935023 XP_008199910.1 1040 4.7e-110 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 644 1.6e-65 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF08925 Domain of Unknown Function (DUF1907) -- -- -- -- GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.50756 BP_3 80.05 1.40 3057 645020639 XP_008207241.1 204 4.4e-13 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01522 Polysaccharide deacetylase GO:0006807//GO:0005975 nitrogen compound metabolic process//carbohydrate metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.50757 BP_3 234.00 6.97 1909 642916317 XP_008190971.1 315 3.7e-26 PREDICTED: uncharacterized protein LOC103312340 [Tribolium castaneum]>gi|270004179|gb|EFA00627.1| hypothetical protein TcasGA2_TC003503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01695//PF00004//PF06309//PF00005//PF03193//PF02562//PF00910//PF00931//PF08047 IstB-like ATP binding protein//ATPase family associated with various cellular activities (AAA)//Torsin//ABC transporter//Protein of unknown function, DUF258//PhoH-like protein//RNA helicase//NB-ARC domain//Histidine operon leader peptide GO:0000105 histidine biosynthetic process GO:0003724//GO:0016887//GO:0005525//GO:0003924//GO:0043531//GO:0003723//GO:0005524 RNA helicase activity//ATPase activity//GTP binding//GTPase activity//ADP binding//RNA binding//ATP binding -- -- -- -- Cluster-8309.50758 BP_3 251.61 5.00 2719 242015216 XP_002428268.1 1387 2.6e-150 cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis]>gi|212512842|gb|EEB15530.1| cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis] 558203653 XM_006132037.1 59 1.95783e-19 PREDICTED: Pelodiscus sinensis mitogen-activated protein kinase kinase 7 (MAP2K7), partial mRNA K04432 MAP2K3, MKK3 mitogen-activated protein kinase kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04432 O09110 1122 5.7e-121 Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus GN=Map2k3 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 Cluster-8309.50759 BP_3 663.98 10.26 3410 91077060 XP_968584.1 3353 0.0e+00 PREDICTED: TBC domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270001739|gb|EEZ98186.1| hypothetical protein TcasGA2_TC000615 [Tribolium castaneum] -- -- -- -- -- K17544 TBCK TBC domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17544 Q8TEA7 1806 3.5e-200 TBC domain-containing protein kinase-like protein OS=Homo sapiens GN=TBCK PE=1 SV=4 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0005622 intracellular KOG1093 Predicted protein kinase (contains TBC and RHOD domains) Cluster-8309.50762 BP_3 15.00 0.31 2657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50766 BP_3 253.30 6.15 2278 91092284 XP_968475.1 1070 1.2e-113 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [Tribolium castaneum]>gi|270001209|gb|EEZ97656.1| hypothetical protein TcasGA2_TC016200 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 486 2.7e-47 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0008152//GO:0042967//GO:0008654//GO:0046486 metabolic process//acyl-carrier-protein biosynthetic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.50771 BP_3 221.14 4.41 2708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50774 BP_3 730.73 12.33 3149 642939483 XP_966848.2 1017 2.4e-107 PREDICTED: transcription elongation factor B polypeptide 3 [Tribolium castaneum]>gi|642939485|ref|XP_008193753.1| PREDICTED: transcription elongation factor B polypeptide 3 [Tribolium castaneum]>gi|270016551|gb|EFA12997.1| hypothetical protein TcasGA2_TC001477 [Tribolium castaneum] -- -- -- -- -- K15076 TCEB3, ELOA transcription elongation factor B, polypeptide 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15076 Q9VCP0 606 4.5e-61 Transcription elongation factor B polypeptide 3 OS=Drosophila melanogaster GN=EloA PE=1 SV=1 PF08711//PF06881 TFIIS helical bundle-like domain//RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006351//GO:0006355 transcription, DNA-templated//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG2821 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin A Cluster-8309.50776 BP_3 69.40 1.38 2713 642921918 XP_008192944.1 1730 4.4e-190 PREDICTED: zinc finger MYND domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5C8 367 2.0e-33 Zinc finger MYND domain-containing protein 11 OS=Mus musculus GN=Zmynd11 PE=1 SV=2 PF00130//PF00439//PF00326//PF02085//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain//Prolyl oligopeptidase family//Class III cytochrome C family//PHD-finger GO:0006508//GO:0006118//GO:0035556 proteolysis//obsolete electron transport//intracellular signal transduction GO:0009055//GO:0008236//GO:0005515//GO:0020037 electron carrier activity//serine-type peptidase activity//protein binding//heme binding -- -- -- -- Cluster-8309.50777 BP_3 33.02 0.45 3830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50778 BP_3 26.50 0.44 3185 91079722 XP_969695.1 2853 0.0e+00 PREDICTED: xenotropic and polytropic retrovirus receptor 1 [Tribolium castaneum]>gi|270003331|gb|EEZ99778.1| hypothetical protein TcasGA2_TC002557 [Tribolium castaneum] 827561892 XM_004932993.2 53 4.97404e-16 PREDICTED: Bombyx mori xenotropic and polytropic retrovirus receptor 1 (LOC101739894), mRNA -- -- -- -- Q9Z0U0 1878 1.5e-208 Xenotropic and polytropic retrovirus receptor 1 OS=Mus musculus GN=Xpr1 PE=1 SV=1 PF03124 EXS family -- -- -- -- GO:0016021 integral component of membrane KOG1162 Predicted small molecule transporter Cluster-8309.50780 BP_3 57.15 0.58 5065 91078484 XP_968508.1 435 1.2e-39 PREDICTED: uncharacterized protein C20orf24 homolog [Tribolium castaneum]>gi|270003855|gb|EFA00303.1| hypothetical protein TcasGA2_TC003138 [Tribolium castaneum] 766924181 XM_011495620.1 92 1.65973e-37 PREDICTED: Ceratosolen solmsi marchali uncharacterized protein C20orf24 homolog (LOC105359127), mRNA -- -- -- -- Q9CQT9 303 9.9e-26 Uncharacterized protein C20orf24 homolog OS=Mus musculus PE=2 SV=1 PF07062 Clc-like -- -- -- -- GO:0016021 integral component of membrane KOG3415 Putative Rab5-interacting protein Cluster-8309.50781 BP_3 224.46 2.41 4773 91078484 XP_968508.1 435 1.1e-39 PREDICTED: uncharacterized protein C20orf24 homolog [Tribolium castaneum]>gi|270003855|gb|EFA00303.1| hypothetical protein TcasGA2_TC003138 [Tribolium castaneum] 766924181 XM_011495620.1 92 1.56336e-37 PREDICTED: Ceratosolen solmsi marchali uncharacterized protein C20orf24 homolog (LOC105359127), mRNA -- -- -- -- Q9CQT9 303 9.4e-26 Uncharacterized protein C20orf24 homolog OS=Mus musculus PE=2 SV=1 PF07062 Clc-like -- -- -- -- GO:0016021 integral component of membrane KOG3415 Putative Rab5-interacting protein Cluster-8309.50788 BP_3 60.54 4.89 889 91080705 XP_975304.1 592 1.3e-58 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270005473|gb|EFA01921.1| hypothetical protein TcasGA2_TC007531 [Tribolium castaneum] -- -- -- -- -- K17353 TSPAN18 tetraspanin-18 http://www.genome.jp/dbget-bin/www_bget?ko:K17353 P27701 236 1.0e-18 CD82 antigen OS=Homo sapiens GN=CD82 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50790 BP_3 17.41 0.63 1632 91090182 XP_966481.1 530 3.7e-51 PREDICTED: methenyltetrahydrofolate synthase domain-containing protein [Tribolium castaneum]>gi|270013764|gb|EFA10212.1| hypothetical protein TcasGA2_TC012407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M296 217 3.0e-16 Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens GN=MTHFSD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4410 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.50792 BP_3 23.47 0.78 1733 642932421 XP_972642.2 1794 1.1e-197 PREDICTED: synaptotagmin-15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P59926 550 7.8e-55 Synaptotagmin-15 OS=Rattus norvegicus GN=Syt15 PE=2 SV=1 PF00168//PF01299 C2 domain//Lysosome-associated membrane glycoprotein (Lamp) -- -- GO:0005515 protein binding GO:0016020 membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.50793 BP_3 12.29 0.47 1562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50795 BP_3 18.00 2.68 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50796 BP_3 47.00 3.03 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.508 BP_3 1.00 0.31 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50800 BP_3 40.08 0.66 3219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50801 BP_3 12243.99 665.14 1179 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50802 BP_3 3.00 0.54 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50803 BP_3 364.28 34.75 797 91085321 XP_969715.1 722 9.8e-74 PREDICTED: lactoylglutathione lyase [Tribolium castaneum]>gi|270009130|gb|EFA05578.1| hypothetical protein TcasGA2_TC015771 [Tribolium castaneum] -- -- -- -- -- K01759 GLO1, gloA lactoylglutathione lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01759 Q6P7Q4 638 2.2e-65 Lactoylglutathione lyase OS=Rattus norvegicus GN=Glo1 PE=1 SV=3 -- -- GO:0005975//GO:0006090 carbohydrate metabolic process//pyruvate metabolic process GO:0004462//GO:0046872 lactoylglutathione lyase activity//metal ion binding -- -- KOG2944 Glyoxalase Cluster-8309.50806 BP_3 109.50 3.93 1634 332374764 AEE62523.1 1431 1.2e-155 unknown [Dendroctonus ponderosae] -- -- -- -- -- K06126 COQ6 ubiquinone biosynthesis monooxygenase Coq6 http://www.genome.jp/dbget-bin/www_bget?ko:K06126 F1RAX8 980 1.0e-104 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Danio rerio GN=coq6 PE=2 SV=1 PF08491//PF01266//PF07992//PF05834//PF01494 Squalene epoxidase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD binding domain GO:0055114//GO:0006694//GO:0016117//GO:0016114 oxidation-reduction process//steroid biosynthetic process//carotenoid biosynthetic process//terpenoid biosynthetic process GO:0004506//GO:0050660//GO:0016491//GO:0016705//GO:0071949 squalene monooxygenase activity//flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding GO:0016021 integral component of membrane KOG3855 Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis Cluster-8309.50808 BP_3 316.28 1.72 9164 642937449 XP_008198840.1 454 1.4e-41 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF07127//PF00042 PHD-finger//Late nodulin protein//Globin GO:0009878 nodule morphogenesis GO:0020037//GO:0046872//GO:0005515//GO:0019825 heme binding//metal ion binding//protein binding//oxygen binding -- -- -- -- Cluster-8309.50810 BP_3 2.00 1.42 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50811 BP_3 16.06 0.55 1688 270001391 EEZ97838.1 1702 4.8e-187 hypothetical protein TcasGA2_TC000207 [Tribolium castaneum] -- -- -- -- -- K05860 PLCE phosphatidylinositol phospholipase C, epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K05860 Q9P212 192 2.5e-13 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 OS=Homo sapiens GN=PLCE1 PE=1 SV=3 PF01241//PF00788 Photosystem I psaG / psaK//Ras association (RalGDS/AF-6) domain GO:0015979//GO:0007165 photosynthesis//signal transduction -- -- GO:0016020//GO:0009522 membrane//photosystem I -- -- Cluster-8309.50812 BP_3 617.94 4.62 6737 642914941 XP_008190451.1 8103 0.0e+00 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like [Tribolium castaneum] 642914940 XM_008192229.1 1528 0 PREDICTED: Tribolium castaneum 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like (LOC661312), mRNA K05860 PLCE phosphatidylinositol phospholipase C, epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K05860 Q8K4S1 1352 3.0e-147 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 OS=Mus musculus GN=Plce1 PE=1 SV=3 PF00788//PF00168//PF00617//PF00387 Ras association (RalGDS/AF-6) domain//C2 domain//RasGEF domain//Phosphatidylinositol-specific phospholipase C, Y domain GO:0007264//GO:0035556//GO:0043087//GO:0006629//GO:0046339//GO:0007165//GO:0009395 small GTPase mediated signal transduction//intracellular signal transduction//regulation of GTPase activity//lipid metabolic process//diacylglycerol metabolic process//signal transduction//phospholipid catabolic process GO:0005515//GO:0005085//GO:0004435 protein binding//guanyl-nucleotide exchange factor activity//phosphatidylinositol phospholipase C activity -- -- -- -- Cluster-8309.50813 BP_3 3.30 0.56 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50814 BP_3 535.72 18.98 1652 646718490 KDR20930.1 993 7.7e-105 hypothetical protein L798_03868 [Zootermopsis nevadensis] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 D4A4K3 586 4.9e-59 Beclin 1-associated autophagy-related key regulator OS=Rattus norvegicus GN=Atg14 PE=3 SV=1 PF03951//PF10186//PF00643 Glutamine synthetase, beta-Grasp domain//Vacuolar sorting 38 and autophagy-related subunit 14//B-box zinc finger GO:0006542//GO:0010508//GO:0006807//GO:0009252 glutamine biosynthetic process//positive regulation of autophagy//nitrogen compound metabolic process//peptidoglycan biosynthetic process GO:0008270//GO:0004356 zinc ion binding//glutamate-ammonia ligase activity GO:0005622 intracellular -- -- Cluster-8309.50815 BP_3 1387.00 155.01 723 478257892 ENN78032.1 370 5.9e-33 hypothetical protein YQE_05469, partial [Dendroctonus ponderosae]>gi|546676206|gb|ERL87273.1| hypothetical protein D910_04669 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03529 Otx1 transcription factor GO:0007275 multicellular organismal development GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.50818 BP_3 46.86 0.50 4813 746863121 XP_011062509.1 3101 0.0e+00 PREDICTED: neither inactivation nor afterpotential protein C isoform X1 [Acromyrmex echinatior]>gi|746863123|ref|XP_011062510.1| PREDICTED: neither inactivation nor afterpotential protein C isoform X1 [Acromyrmex echinatior] -- -- -- -- -- K08834 MYO3, DFNB30 myosin III http://www.genome.jp/dbget-bin/www_bget?ko:K08834 P10676 2639 1.3e-296 Neither inactivation nor afterpotential protein C OS=Drosophila melanogaster GN=ninaC PE=1 SV=2 PF01991//PF06293//PF00069//PF00612//PF00063//PF05337//PF07714 ATP synthase (E/31 kDa) subunit//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//IQ calmodulin-binding motif//Myosin head (motor domain)//Macrophage colony stimulating factor-1 (CSF-1)//Protein tyrosine kinase GO:0007165//GO:0006468//GO:0015992//GO:0040007//GO:0008283//GO:0015991//GO:0006119 signal transduction//protein phosphorylation//proton transport//growth//cell proliferation//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0005524//GO:0005125//GO:0046961//GO:0008083//GO:0005515//GO:0003774//GO:0016773//GO:0004672 ATP binding//cytokine activity//proton-transporting ATPase activity, rotational mechanism//growth factor activity//protein binding//motor activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016459//GO:0016021//GO:0033178//GO:0016020 myosin complex//integral component of membrane//proton-transporting two-sector ATPase complex, catalytic domain//membrane -- -- Cluster-8309.5082 BP_3 85.00 1.47 3071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13724 DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.50820 BP_3 1.00 4.30 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50824 BP_3 2.00 9.74 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50826 BP_3 8.51 0.95 725 642914292 XP_008201625.1 458 3.7e-43 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 -- -- -- -- PF08935 Viral protein VP4 subunit -- -- -- -- GO:0019030 icosahedral viral capsid -- -- Cluster-8309.50828 BP_3 119.17 0.68 8680 270017072 EFA13518.1 2053 4.9e-227 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1356 1.3e-147 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00098//PF00665 Integrase core domain//Zinc knuckle//Integrase core domain GO:0015074 DNA integration GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.50829 BP_3 30.00 3.65 688 861631908 KMQ90492.1 184 2.1e-11 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50831 BP_3 38.05 0.45 4377 642917250 XP_967285.3 815 8.9e-84 PREDICTED: SPARC-related modular calcium-binding protein 2 isoform X2 [Tribolium castaneum] 642917249 XM_962192.3 115 2.34702e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA -- -- -- -- Q8BLY1 323 4.1e-28 SPARC-related modular calcium-binding protein 1 OS=Mus musculus GN=Smoc1 PE=2 SV=2 PF13499//PF00506//PF13833//PF13405//PF10591//PF00036//PF09398//PF02829//PF13202 EF-hand domain pair//Influenza virus nucleoprotein//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//FOP N terminal dimerisation domain//3H domain//EF hand GO:0034453//GO:0007165 microtubule anchoring//signal transduction GO:0005509//GO:0005198//GO:0036094 calcium ion binding//structural molecule activity//small molecule binding GO:0005578//GO:0005815 proteinaceous extracellular matrix//microtubule organizing center KOG4578 Uncharacterized conserved protein, contains KAZAL and TY domains Cluster-8309.50839 BP_3 3.12 0.56 559 642911480 XP_008199442.1 450 2.4e-42 PREDICTED: retinol dehydrogenase 13-like [Tribolium castaneum]>gi|270014891|gb|EFA11339.1| hypothetical protein TcasGA2_TC010879 [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8BYK4 315 4.4e-28 Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2 SV=1 PF00106 short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0000166//GO:0016491 nucleotide binding//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.5084 BP_3 27.00 1.04 1543 607367538 EZA61679.1 185 3.5e-11 hypothetical protein X777_10511, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50841 BP_3 6.88 0.89 664 642911480 XP_008199442.1 770 2.2e-79 PREDICTED: retinol dehydrogenase 13-like [Tribolium castaneum]>gi|270014891|gb|EFA11339.1| hypothetical protein TcasGA2_TC010879 [Tribolium castaneum] -- -- -- -- -- K11152 RDH11 retinol dehydrogenase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11152 Q8TC12 508 2.2e-50 Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0000166//GO:0016491 nucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.50843 BP_3 14.50 0.33 2391 642925978 XP_967909.2 1119 2.7e-119 PREDICTED: UNC93-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 304 3.6e-26 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50844 BP_3 57.50 1.26 2492 642925978 XP_967909.2 1119 2.8e-119 PREDICTED: UNC93-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 304 3.7e-26 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50846 BP_3 80.99 1.32 3247 642936096 XP_008198301.1 2202 9.7e-245 PREDICTED: PR domain zinc finger protein 10-like isoform X2 [Tribolium castaneum] 780701311 XM_011703805.1 79 1.7859e-30 PREDICTED: Wasmannia auropunctata PR domain zinc finger protein 10-like (LOC105458476), transcript variant X2, mRNA -- -- -- -- Q5RAX9 917 4.0e-97 PR domain zinc finger protein 10 OS=Pongo abelii GN=PRDM10 PE=2 SV=1 PF13912//PF09803//PF13465//PF00096 C2H2-type zinc finger//Uncharacterized conserved protein (DUF2346)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0033617 mitochondrial respiratory chain complex IV assembly GO:0046872 metal ion binding GO:0005739 mitochondrion -- -- Cluster-8309.50848 BP_3 44.82 0.64 3673 642910357 XP_008200291.1 4326 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase Genghis Khan [Tribolium castaneum] 242024079 XM_002432413.1 313 1.68297e-160 Pediculus humanus corporis serine/threonine-protein kinase MRCK beta, putative, mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q5VT25 1633 4.3e-180 Serine/threonine-protein kinase MRCK alpha OS=Homo sapiens GN=CDC42BPA PE=1 SV=1 PF01291//PF00130//PF08826//PF00069//PF00433//PF07714 LIF / OSM family//Phorbol esters/diacylglycerol binding domain (C1 domain)//DMPK coiled coil domain like//Protein kinase domain//Protein kinase C terminal domain//Protein tyrosine kinase GO:0006955//GO:0035556//GO:0007165//GO:0016310//GO:0009069//GO:0006468 immune response//intracellular signal transduction//signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005125//GO:0004674//GO:0004672//GO:0005524 cytokine activity//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0005576 extracellular region KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.50849 BP_3 910.96 10.79 4362 642936291 XP_008198385.1 4280 0.0e+00 PREDICTED: nuclear pore complex protein Nup160 homolog [Tribolium castaneum] -- -- -- -- -- K14303 NUP160, NUP120 nuclear pore complex protein Nup160 http://www.genome.jp/dbget-bin/www_bget?ko:K14303 Q9VKJ3 1743 9.0e-193 Nuclear pore complex protein Nup160 homolog OS=Drosophila melanogaster GN=Nup160 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50851 BP_3 80.90 6.70 874 270008756 EFA05204.1 320 4.4e-27 hypothetical protein TcasGA2_TC015340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12276 166 1.3e-10 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.50852 BP_3 418.27 4.42 4850 642925057 XP_008194153.1 5276 0.0e+00 PREDICTED: tectonin beta-propeller repeat-containing protein isoform X4 [Tribolium castaneum] 874475179 XM_013100081.1 39 4.60893e-08 PREDICTED: Anas platyrhynchos tectonin beta-propeller repeat containing 1 (TECPR1), transcript variant X4, mRNA K17988 TECPR1 tectonin beta-propeller repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17988 Q9VWB0 1850 3.9e-205 Tectonin beta-propeller repeat-containing protein OS=Drosophila melanogaster GN=Pex23 PE=2 SV=2 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.50853 BP_3 319.62 3.50 4689 189237993 XP_001812825.1 5381 0.0e+00 PREDICTED: tectonin beta-propeller repeat-containing protein isoform X2 [Tribolium castaneum] 874475179 XM_013100081.1 39 4.45479e-08 PREDICTED: Anas platyrhynchos tectonin beta-propeller repeat containing 1 (TECPR1), transcript variant X4, mRNA K17988 TECPR1 tectonin beta-propeller repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17988 Q9VWB0 1864 9.0e-207 Tectonin beta-propeller repeat-containing protein OS=Drosophila melanogaster GN=Pex23 PE=2 SV=2 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.50854 BP_3 33.52 0.47 3710 642925057 XP_008194153.1 4997 0.0e+00 PREDICTED: tectonin beta-propeller repeat-containing protein isoform X4 [Tribolium castaneum] 874475179 XM_013100081.1 39 3.51749e-08 PREDICTED: Anas platyrhynchos tectonin beta-propeller repeat containing 1 (TECPR1), transcript variant X4, mRNA K17988 TECPR1 tectonin beta-propeller repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17988 Q9VWB0 1682 9.1e-186 Tectonin beta-propeller repeat-containing protein OS=Drosophila melanogaster GN=Pex23 PE=2 SV=2 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.50856 BP_3 291.10 2.69 5505 642927195 XP_008195175.1 2564 1.7e-286 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50857 BP_3 79.04 0.73 5501 642927195 XP_008195175.1 2564 1.7e-286 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50858 BP_3 74.00 1.37 2896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08063//PF09596 PADR1 (NUC008) domain//MamL-1 domain GO:0045944//GO:0007219 positive regulation of transcription from RNA polymerase II promoter//Notch signaling pathway GO:0003713//GO:0003950 transcription coactivator activity//NAD+ ADP-ribosyltransferase activity GO:0005667//GO:0016607//GO:0005634 transcription factor complex//nuclear speck//nucleus -- -- Cluster-8309.50859 BP_3 9.00 2.29 481 514692343 XP_004993744.1 207 3.1e-14 hypothetical protein PTSG_12268 [Salpingoeca rosetta]>gi|326427892|gb|EGD73462.1| hypothetical protein PTSG_12268 [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5086 BP_3 17.31 1.22 973 270015294 EFA11742.1 448 7.1e-42 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50860 BP_3 23.81 0.80 1726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50861 BP_3 912.56 17.71 2776 546684003 ERL93732.1 2078 2.0e-230 hypothetical protein D910_11018 [Dendroctonus ponderosae] 642929691 XM_970420.3 420 0 PREDICTED: Tribolium castaneum splicing factor 3B subunit 2 (LOC664413), transcript variant X2, mRNA K12829 SF3B2, SAP145, CUS1 splicing factor 3B subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12829 Q13435 1529 3.7e-168 Splicing factor 3B subunit 2 OS=Homo sapiens GN=SF3B2 PE=1 SV=2 PF04998//PF04037 RNA polymerase Rpb1, domain 5//Domain of unknown function (DUF382) GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005730 nucleus//nucleolus KOG2330 Splicing factor 3b, subunit 2 Cluster-8309.50862 BP_3 199.49 3.15 3347 260795637 XP_002592811.1 669 5.8e-67 hypothetical protein BRAFLDRAFT_275668 [Branchiostoma floridae]>gi|229278035|gb|EEN48822.1| hypothetical protein BRAFLDRAFT_275668, partial [Branchiostoma floridae] 815905920 XM_012383378.1 159 6.21471e-75 PREDICTED: Bombus impatiens another transcription unit protein (LOC100742825), transcript variant X2, mRNA K15177 LEO1 RNA polymerase-associated protein LEO1 http://www.genome.jp/dbget-bin/www_bget?ko:K15177 Q05481 646 1.1e-65 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF07776//PF00096//PF00130//PF01363//PF04004//PF13912//PF00346//PF16622//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//FYVE zinc finger//Leo1-like protein//C2H2-type zinc finger//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//zinc-finger C2H2-type//Zinc-finger double domain GO:0016570//GO:0035556//GO:0055114//GO:0006368 histone modification//intracellular signal transduction//oxidation-reduction process//transcription elongation from RNA polymerase II promoter GO:0008270//GO:0048038//GO:0046872//GO:0051287//GO:0016651 zinc ion binding//quinone binding//metal ion binding//NAD binding//oxidoreductase activity, acting on NAD(P)H GO:0016593//GO:0005634 Cdc73/Paf1 complex//nucleus -- -- Cluster-8309.50865 BP_3 21.73 0.47 2518 642930142 XP_008196269.1 1873 1.1e-206 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X3 [Tribolium castaneum] 189164165 EU545256.1 262 2.57745e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1247 1.7e-135 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.50866 BP_3 15.62 0.84 1192 189164166 ACD77184.1 1175 4.4e-126 putative hepatocyte nuclear factor 4 nuclear hormone receptor [Callosobruchus maculatus] 189164165 EU545256.1 262 1.20101e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 753 1.5e-78 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.50867 BP_3 601.89 10.72 2999 662209763 XP_008478495.1 561 1.7e-54 PREDICTED: uncharacterized protein LOC103515333 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.50868 BP_3 176.67 1.28 6954 386763496 NP_001245440.1 5465 0.0e+00 calcium activated protein for secretion, isoform E [Drosophila melanogaster]>gi|383293108|gb|AFH06800.1| calcium activated protein for secretion, isoform E [Drosophila melanogaster] 642910886 XM_008195228.1 1198 0 PREDICTED: Tribolium castaneum calcium-dependent secretion activator (LOC660877), transcript variant X6, mRNA -- -- -- -- Q9NHE5 3654 0.0e+00 Calcium-dependent secretion activator OS=Drosophila melanogaster GN=Caps PE=1 SV=3 PF11615 Protein of unknown function (DUF3249) GO:0072499//GO:0007476//GO:0016079//GO:0035249//GO:0000266//GO:0016477//GO:0008045//GO:0035147//GO:0046331//GO:0007156 photoreceptor cell axon guidance//imaginal disc-derived wing morphogenesis//synaptic vesicle exocytosis//synaptic transmission, glutamatergic//mitochondrial fission//cell migration//motor neuron axon guidance//branch fusion, open tracheal system//lateral inhibition//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005543 phospholipid binding GO:0005739//GO:0016020//GO:0042995//GO:0008021 mitochondrion//membrane//cell projection//synaptic vesicle KOG3543 Ca2+-dependent activator protein Cluster-8309.50871 BP_3 580.94 19.55 1724 642914683 XP_001815109.2 276 1.1e-21 PREDICTED: uncharacterized protein LOC100142559 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01093 Clusterin GO:0008219 cell death -- -- -- -- -- -- Cluster-8309.50872 BP_3 1164.93 19.70 3142 642920703 XP_008192529.1 303 1.5e-24 PREDICTED: beta-taxilin-like isoform X2 [Tribolium castaneum]>gi|270006091|gb|EFA02539.1| hypothetical protein TcasGA2_TC008244 [Tribolium castaneum] -- -- -- -- -- K15712 TTC3 E3 ubiquitin-protein ligase TTC3 http://www.genome.jp/dbget-bin/www_bget?ko:K15712 Q86Y13 157 5.2e-09 E3 ubiquitin-protein ligase DZIP3 OS=Homo sapiens GN=DZIP3 PE=1 SV=2 PF13639//PF04420//PF12861//PF03938//PF11789//PF00097//PF14634//PF17123//PF12906//PF12678 Ring finger domain//CHD5-like protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Outer membrane protein (OmpH-like)//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-like zinc finger//RING-variant domain//RING-H2 zinc finger GO:0016567//GO:0071816 protein ubiquitination//tail-anchored membrane protein insertion into ER membrane GO:0004842//GO:0005515//GO:0046872//GO:0051082//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//unfolded protein binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.50875 BP_3 98.32 0.95 5289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09004//PF17053//PF03854 Domain of unknown function (DUF1891)//Genetic interactor of prohibitin 5//P-11 zinc finger GO:0055114//GO:0000002 oxidation-reduction process//mitochondrial genome maintenance GO:0003723//GO:0008168//GO:0008270//GO:0016706 RNA binding//methyltransferase activity//zinc ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.50876 BP_3 364.11 10.45 1971 531445092 AGT57838.1 975 1.1e-102 cytochrome P450 413a1 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V4U7 362 5.6e-33 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067//PF01833 Cytochrome P450//IPT/TIG domain GO:0055114 oxidation-reduction process GO:0020037//GO:0005515//GO:0005506//GO:0016705 heme binding//protein binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.50878 BP_3 42.27 0.53 4119 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50880 BP_3 183.73 2.33 4089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50883 BP_3 31.43 0.37 4337 642917429 XP_008191194.1 1503 1.5e-163 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1L258 1264 3.1e-137 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF01565//PF08558//PF02913 FAD binding domain//Telomere repeat binding factor (TRF)//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0042803//GO:0003824//GO:0050660//GO:0042162//GO:0016491 protein homodimerization activity//catalytic activity//flavin adenine dinucleotide binding//telomeric DNA binding//oxidoreductase activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.50885 BP_3 487.90 6.91 3693 847046522 XP_012807721.1 797 9.2e-82 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 260-like [Jaculus jaculus] -- -- -- -- -- -- -- -- -- Q14590 769 6.7e-80 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF00096//PF02022//PF13465//PF13912//PF02723//PF07776 Zinc finger, C2H2 type//Integrase Zinc binding domain//Zinc-finger double domain//C2H2-type zinc finger//Non-structural protein NS3/Small envelope protein E//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.50888 BP_3 103.97 0.93 5665 91089161 XP_973772.1 3055 0.0e+00 PREDICTED: probable G-protein coupled receptor CG31760 [Tribolium castaneum] 642932771 XM_968679.2 444 0 PREDICTED: Tribolium castaneum probable G-protein coupled receptor CG31760 (LOC662590), mRNA -- -- -- -- Q9VKA4 2243 1.2e-250 Probable G-protein coupled receptor CG31760 OS=Drosophila melanogaster GN=CG31760 PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50890 BP_3 52.38 1.72 1763 642920867 XP_008192592.1 2528 8.3e-283 PREDICTED: protein turtle isoform X7 [Tribolium castaneum] 780702434 XM_011704077.1 434 0 PREDICTED: Wasmannia auropunctata protein turtle (LOC105458610), mRNA -- -- -- -- Q967D7 2226 3.6e-249 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF16656//PF07354//PF00041//PF13895//PF01108 Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Immunoglobulin domain//Tissue factor GO:0007339//GO:0019497//GO:0006771 binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity GO:0005576 extracellular region -- -- Cluster-8309.50891 BP_3 103.84 0.72 7267 642920861 XP_008192589.1 3390 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 780702434 XM_011704077.1 550 0 PREDICTED: Wasmannia auropunctata protein turtle (LOC105458610), mRNA -- -- -- -- Q967D7 2951 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF07353//PF02480//PF16656//PF13895//PF07354//PF00041//PF01108 Uroplakin II//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Tissue factor GO:0061024//GO:0006771//GO:0007339//GO:0019497 membrane organization//riboflavin metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0005576//GO:0016020//GO:0030176 extracellular region//membrane//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.50894 BP_3 4.83 1.41 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50895 BP_3 2.00 27.51 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50896 BP_3 5.00 11.12 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50897 BP_3 170.30 3.95 2369 560922390 XP_006187394.1 378 2.3e-33 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 782-like [Camelus ferus] -- -- -- -- -- -- -- -- -- Q1LYE3 221 1.5e-16 Zinc finger protein 143 OS=Danio rerio GN=znf143 PE=2 SV=2 PF00096//PF13465//PF16622//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.50899 BP_3 8.00 0.32 1504 642927984 XP_008195472.1 747 2.3e-76 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5090 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.50905 BP_3 482.69 24.00 1261 642914504 XP_008201703.1 1370 1.1e-148 PREDICTED: RUN and FYVE domain-containing protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WXA3 700 2.3e-72 RUN and FYVE domain-containing protein 2 OS=Homo sapiens GN=RUFY2 PE=1 SV=2 PF06005 Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly -- -- GO:0005737 cytoplasm -- -- Cluster-8309.50906 BP_3 407.71 13.62 1735 728416727 AIY68319.1 1451 6.3e-158 putative beta-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 893 1.3e-94 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.50907 BP_3 156.49 1.29 6128 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50909 BP_3 55.66 1.52 2054 270014998 EFA11446.1 1919 4.0e-212 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] 746860780 XM_011062944.1 41 1.49476e-09 PREDICTED: Acromyrmex echinatior xanthine dehydrogenase-like (LOC105150088), transcript variant X2, mRNA -- -- -- -- P47990 835 8.2e-88 Xanthine dehydrogenase/oxidase OS=Gallus gallus GN=XDH PE=1 SV=1 PF02738//PF01313 Molybdopterin-binding domain of aldehyde dehydrogenase//Bacterial export proteins, family 3 GO:0055114//GO:0009306 oxidation-reduction process//protein secretion GO:0016491 oxidoreductase activity GO:0016020 membrane KOG0430 Xanthine dehydrogenase Cluster-8309.50910 BP_3 32.74 1.01 1847 478257586 ENN77740.1 1716 1.3e-188 hypothetical protein YQE_05810, partial [Dendroctonus ponderosae] 746860780 XM_011062944.1 41 1.34151e-09 PREDICTED: Acromyrmex echinatior xanthine dehydrogenase-like (LOC105150088), transcript variant X2, mRNA -- -- -- -- P47990 758 6.3e-79 Xanthine dehydrogenase/oxidase OS=Gallus gallus GN=XDH PE=1 SV=1 PF01313//PF02738 Bacterial export proteins, family 3//Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114//GO:0009306 oxidation-reduction process//protein secretion GO:0016491 oxidoreductase activity GO:0016020 membrane KOG0430 Xanthine dehydrogenase Cluster-8309.50911 BP_3 28.76 0.87 1894 478259581 ENN79434.1 737 4.3e-75 hypothetical protein YQE_04078, partial [Dendroctonus ponderosae]>gi|546686694|gb|ERL95804.1| hypothetical protein D910_00332 [Dendroctonus ponderosae]>gi|546687578|gb|ERL96217.1| hypothetical protein D910_01476 [Dendroctonus ponderosae] -- -- -- -- -- K12193 VPS24, CHMP3 charged multivesicular body protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12193 Q4R574 569 5.3e-57 Charged multivesicular body protein 3 OS=Macaca fascicularis GN=CHMP3 PE=2 SV=3 PF03357 Snf7 GO:0007034 vacuolar transport -- -- -- -- KOG3229 Vacuolar sorting protein VPS24 Cluster-8309.50913 BP_3 322.53 4.26 3937 242016957 XP_002428961.1 2569 3.3e-287 tubulin-specific chaperone D, putative [Pediculus humanus corporis]>gi|212513790|gb|EEB16223.1| tubulin-specific chaperone D, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q5ZI87 2014 3.1e-224 Tubulin-specific chaperone D OS=Gallus gallus GN=TBCD PE=2 SV=1 PF02985//PF08429 HEAT repeat//PLU-1-like protein GO:0055114 oxidation-reduction process GO:0005515//GO:0016706 protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- KOG1943 Beta-tubulin folding cofactor D Cluster-8309.50914 BP_3 120.79 1.52 4133 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50916 BP_3 11.18 0.72 1040 270012018 EFA08466.1 480 1.5e-45 hypothetical protein TcasGA2_TC006115 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 282 5.5e-24 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 PF05041 Pecanex protein (C-terminus) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50919 BP_3 27.27 0.96 1655 642930331 XP_008196350.1 653 2.0e-65 PREDICTED: ataxin-10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28658 193 1.8e-13 Ataxin-10 OS=Mus musculus GN=Atxn10 PE=1 SV=2 PF02405//PF01320 Permease MlaE//Colicin immunity protein / pyocin immunity protein GO:0006810//GO:0006955 transport//immune response GO:0015643 toxic substance binding GO:0019814//GO:0043190 immunoglobulin complex//ATP-binding cassette (ABC) transporter complex -- -- Cluster-8309.50920 BP_3 36.67 1.32 1632 189238634 XP_001811204.1 1894 2.5e-209 PREDICTED: tubulin gamma-1 chain isoform X2 [Tribolium castaneum] 532072251 XM_005321887.1 177 2.95637e-85 PREDICTED: Spermophilus tridecemlineatus tubulin, gamma 2 (Tubg2), mRNA K10389 TUBG tubulin gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10389 Q32KM1 1697 7.3e-188 Tubulin gamma-2 chain OS=Bos taurus GN=TUBG2 PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1374 Gamma tubulin Cluster-8309.50922 BP_3 758.67 34.62 1348 642933817 XP_008197388.1 674 6.1e-68 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TN34 370 4.5e-34 MICAL-like protein 2 OS=Mus musculus GN=Micall2 PE=1 SV=1 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50925 BP_3 63.02 1.65 2129 675372920 KFM65822.1 141 6.2e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50927 BP_3 35.53 0.54 3480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50930 BP_3 78.78 1.43 2951 646710326 KDR15870.1 2105 1.6e-233 Dual serine/threonine and tyrosine protein kinase, partial [Zootermopsis nevadensis] -- -- -- -- -- K16288 RIPK5, DSTYK receptor-interacting serine/threonine-protein kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16288 Q1L6Q1 1864 5.7e-207 Dual serine/threonine and tyrosine protein kinase OS=Apis mellifera GN=DSTYK PE=2 SV=1 PF00069//PF01442//PF06293//PF07714//PF04390//PF04614 Protein kinase domain//Apolipoprotein A1/A4/E domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Lipopolysaccharide-assembly//Pex19 protein family GO:0006869//GO:0006468//GO:0042157//GO:0043165 lipid transport//protein phosphorylation//lipoprotein metabolic process//Gram-negative-bacterium-type cell outer membrane assembly GO:0005524//GO:0008289//GO:0004672//GO:0016773 ATP binding//lipid binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0005777//GO:0019867//GO:0005576//GO:0016020 peroxisome//outer membrane//extracellular region//membrane -- -- Cluster-8309.50931 BP_3 3.60 0.49 644 546685957 ERL95371.1 235 2.3e-17 hypothetical protein D910_12635, partial [Dendroctonus ponderosae] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 -- -- -- -- PF00344//PF00957 SecY translocase//Synaptobrevin GO:0016192//GO:0015031 vesicle-mediated transport//protein transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.50933 BP_3 91.00 0.69 6603 546678769 ERL89321.1 3207 0.0e+00 hypothetical protein D910_06693 [Dendroctonus ponderosae] 815816223 XM_012373772.1 303 1.10019e-154 PREDICTED: Linepithema humile protein stoned-B (LOC105676122), transcript variant X2, mRNA -- -- -- -- Q24212 2445 5.4e-274 Protein stoned-B OS=Drosophila melanogaster GN=stnB PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2677 Stoned B synaptic vesicle biogenesis protein Cluster-8309.50935 BP_3 123.16 2.30 2873 642920771 XP_008192553.1 1321 1.2e-142 PREDICTED: spondin-1-like [Tribolium castaneum]>gi|270005186|gb|EFA01634.1| hypothetical protein TcasGA2_TC007204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 831 3.4e-87 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF08943//PF08925 CsiD//Domain of Unknown Function (DUF1907) -- -- GO:0005506 iron ion binding GO:0005634 nucleus KOG3539 Spondins, extracellular matrix proteins Cluster-8309.50938 BP_3 65.32 1.48 2424 478250251 ENN70751.1 405 1.7e-36 hypothetical protein YQE_12540, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609//PF09057 Plant transposon protein//Transposase DDE domain//Second Mitochondria-derived Activator of Caspases GO:0006919//GO:0006313//GO:0006915 activation of cysteine-type endopeptidase activity involved in apoptotic process//transposition, DNA-mediated//apoptotic process GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity GO:0005739 mitochondrion -- -- Cluster-8309.50939 BP_3 14.62 0.33 2411 478250251 ENN70751.1 814 6.4e-84 hypothetical protein YQE_12540, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AZB8 220 2.0e-16 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF09057//PF04827 Second Mitochondria-derived Activator of Caspases//Plant transposon protein GO:0006919//GO:0006915 activation of cysteine-type endopeptidase activity involved in apoptotic process//apoptotic process GO:0016788 hydrolase activity, acting on ester bonds GO:0005739 mitochondrion -- -- Cluster-8309.50940 BP_3 31.22 0.60 2785 270001480 EEZ97927.1 1278 1.2e-137 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M3K2 465 8.9e-45 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF01025 GrpE GO:0006457 protein folding GO:0000774//GO:0051087//GO:0042803 adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity -- -- -- -- Cluster-8309.50941 BP_3 512.95 8.82 3095 189239405 XP_001813943.1 3364 0.0e+00 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] 637379439 XM_008125298.1 41 2.26402e-09 PREDICTED: Anolis carolinensis nuclear export mediator factor NEMF-like (LOC103282578), mRNA -- -- -- -- Q9VBX1 2205 1.7e-246 Nuclear export mediator factor NEMF homolog OS=Drosophila melanogaster GN=Clbn PE=1 SV=2 PF08052 PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process -- -- -- -- KOG2030 Predicted RNA-binding protein Cluster-8309.50943 BP_3 18.51 0.49 2104 189239405 XP_001813943.1 2436 4.6e-272 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60524 1740 9.7e-193 Nuclear export mediator factor NEMF OS=Homo sapiens GN=NEMF PE=1 SV=4 PF05615//PF02050//PF08052 Tho complex subunit 7//Flagellar FliJ protein//PyrBI operon leader peptide GO:0019856//GO:0071973//GO:0006397//GO:0006935 pyrimidine nucleobase biosynthetic process//bacterial-type flagellum-dependent cell motility//mRNA processing//chemotaxis GO:0003774 motor activity GO:0000445//GO:0016020//GO:0009288 THO complex part of transcription export complex//membrane//bacterial-type flagellum KOG2030 Predicted RNA-binding protein Cluster-8309.50945 BP_3 13.77 0.31 2403 642921818 XP_008199331.1 1173 1.5e-125 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] -- -- -- -- -- K10106 GGCX vitamin K-dependent gamma-carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10106 Q9MYY3 693 2.8e-71 Vitamin K-dependent gamma-carboxylase OS=Delphinapterus leucas GN=GGCX PE=2 SV=1 PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.50946 BP_3 128.81 1.57 4250 91077592 XP_973319.1 1821 1.9e-200 PREDICTED: decaprenyl-diphosphate synthase subunit 1 [Tribolium castaneum] 645030079 XM_008211983.1 197 5.94392e-96 PREDICTED: Nasonia vitripennis decaprenyl-diphosphate synthase subunit 1 (LOC100118369), transcript variant X4, mRNA K12504 PDSS1 decaprenyl-diphosphate synthase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12504 Q5T2R2 916 6.9e-97 Decaprenyl-diphosphate synthase subunit 1 OS=Homo sapiens GN=PDSS1 PE=1 SV=1 PF01783//PF00348 Ribosomal L32p protein family//Polyprenyl synthetase GO:0008299//GO:0006412//GO:0042254 isoprenoid biosynthetic process//translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.50949 BP_3 196.04 9.95 1241 642916768 XP_008192537.1 517 9.0e-50 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q8SXQ7 284 3.9e-24 Peptidoglycan-recognition protein LF OS=Drosophila melanogaster GN=PGRP-LF PE=1 SV=1 PF06422//PF01510 CDR ABC transporter//N-acetylmuramoyl-L-alanine amidase GO:0006810//GO:0009253//GO:0009252//GO:0006807 transport//peptidoglycan catabolic process//peptidoglycan biosynthetic process//nitrogen compound metabolic process GO:0005524//GO:0042626//GO:0008745 ATP binding//ATPase activity, coupled to transmembrane movement of substances//N-acetylmuramoyl-L-alanine amidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50950 BP_3 195.00 2.80 3645 91087405 XP_975667.1 2806 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 5 [Tribolium castaneum]>gi|270009507|gb|EFA05955.1| hypothetical protein TcasGA2_TC008773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CG46 1362 1.1e-148 Structural maintenance of chromosomes protein 5 OS=Mus musculus GN=Smc5 PE=2 SV=1 PF13851//PF02183//PF13304 Growth-arrest specific micro-tubule binding//Homeobox associated leucine zipper//AAA domain, putative AbiEii toxin, Type IV TA system GO:0048870//GO:0006355 cell motility//regulation of transcription, DNA-templated GO:0003700//GO:0005524//GO:0043565 transcription factor activity, sequence-specific DNA binding//ATP binding//sequence-specific DNA binding GO:0005667//GO:0031514 transcription factor complex//motile cilium KOG0979 Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily Cluster-8309.50951 BP_3 47.36 3.04 1042 642933095 XP_008197256.1 395 1.1e-35 PREDICTED: protein Gawky isoform X1 [Tribolium castaneum]>gi|642933097|ref|XP_008197257.1| PREDICTED: protein Gawky isoform X1 [Tribolium castaneum] 642933104 XM_008199038.1 408 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50958 BP_3 18.81 0.42 2454 91086747 XP_971978.1 710 7.5e-72 PREDICTED: tafazzin homolog [Tribolium castaneum] -- -- -- -- -- K13511 TAZ monolysocardiolipin acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13511 Q9V6G5 527 5.1e-52 Tafazzin homolog OS=Drosophila melanogaster GN=Taz PE=2 SV=2 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG2847 Phosphate acyltransferase Cluster-8309.5096 BP_3 125.00 2.35 2852 642917435 XP_008191197.1 979 5.6e-103 PREDICTED: uncharacterized protein LOC103312417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50962 BP_3 56.97 2.27 1499 861635858 KMQ91682.1 1413 1.4e-153 wd repeat-containing protein 35-like protein [Lasius niger] 780035245 XM_778124.4 37 1.8137e-07 PREDICTED: Strongylocentrotus purpuratus WD repeat-containing protein 35 (LOC577925), transcript variant X3, mRNA -- -- -- -- A6N6J5 1341 1.3e-146 WD repeat-containing protein 35 OS=Rattus norvegicus GN=Wdr35 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2503 Tubby superfamily protein TULP4 Cluster-8309.50965 BP_3 16.71 0.40 2309 91078176 XP_967241.1 1763 5.6e-194 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 1332 2.2e-145 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- GO:0006804//GO:0055114//GO:0006979 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress GO:0020037//GO:0004601 heme binding//peroxidase activity -- -- -- -- Cluster-8309.50966 BP_3 99.00 3.83 1537 478254156 ENN74435.1 873 5.9e-91 hypothetical protein YQE_08970, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O54905 329 2.9e-29 Beta-1,3-galactosyltransferase 2 OS=Mus musculus GN=B3galt2 PE=2 SV=2 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.50967 BP_3 604.56 5.04 6074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50968 BP_3 379.03 8.60 2415 532107609 XP_005338536.1 469 6.5e-44 PREDICTED: zinc finger protein 420-like [Ictidomys tridecemlineatus] -- -- -- -- -- -- -- -- -- Q9UJU3 432 5.2e-41 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13912//PF16622//PF05191//PF00096//PF10392//PF13465 C2H2-type zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Golgi transport complex subunit 5//Zinc-finger double domain GO:0006891//GO:0046034//GO:0006144 intra-Golgi vesicle-mediated transport//ATP metabolic process//purine nucleobase metabolic process GO:0046872//GO:0004017 metal ion binding//adenylate kinase activity GO:0017119 Golgi transport complex -- -- Cluster-8309.50970 BP_3 11.00 2.89 475 328703894 XP_001945611.2 153 5.6e-08 PREDICTED: uncharacterized protein LOC100164320 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50972 BP_3 209.45 3.77 2973 91085955 XP_971224.1 3102 0.0e+00 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q80V86 755 2.3e-78 Integrator complex subunit 8 OS=Mus musculus GN=Ints8 PE=2 SV=1 PF00515//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50976 BP_3 5.80 0.36 1074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50977 BP_3 705.50 12.12 3097 91089209 XP_967093.1 2991 0.0e+00 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog [Tribolium castaneum]>gi|270012470|gb|EFA08918.1| hypothetical protein TcasGA2_TC006624 [Tribolium castaneum] -- -- -- -- -- K14439 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14439 Q9VL72 1791 1.7e-198 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog OS=Drosophila melanogaster GN=Etl1 PE=1 SV=1 PF00270//PF00176//PF02845//PF04851 DEAD/DEAH box helicase//SNF2 family N-terminal domain//CUE domain//Type III restriction enzyme, res subunit -- -- GO:0005515//GO:0003676//GO:0003677//GO:0016787//GO:0005524 protein binding//nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0389 SNF2 family DNA-dependent ATPase Cluster-8309.50979 BP_3 216.42 2.27 4893 478251175 ENN71651.1 1463 7.2e-159 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 Q9P2N4 773 3.0e-80 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.50980 BP_3 40.06 1.03 2175 742090774 XP_010831732.1 722 2.7e-73 PREDICTED: zinc finger protein 665-like, partial [Bison bison bison] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZN08 696 1.1e-71 Putative zinc finger protein 66 OS=Homo sapiens GN=ZNF66 PE=5 SV=3 PF07776//PF16622//PF13912//PF05864//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.50983 BP_3 530.67 10.14 2815 642912548 XP_008200908.1 1126 5.0e-120 PREDICTED: collagen and calcium-binding EGF domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXH8 366 2.7e-33 Collagen and calcium-binding EGF domain-containing protein 1 OS=Homo sapiens GN=CCBE1 PE=1 SV=1 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.50985 BP_3 67.94 1.40 2633 270013970 EFA10418.1 447 2.5e-41 hypothetical protein TcasGA2_TC012658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50986 BP_3 237.09 5.20 2490 642935733 XP_008198149.1 915 1.3e-95 PREDICTED: proteoglycan 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50987 BP_3 20516.17 643.26 1829 270008070 EFA04518.1 612 1.3e-60 hypothetical protein TcasGA2_TC016313 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50989 BP_3 96.30 0.60 7999 642920861 XP_008192589.1 3650 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 630 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3150 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF07353//PF02480//PF16656//PF07354//PF13895//PF00041 Tissue factor//Uroplakin II//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0061024//GO:0019497//GO:0007339 riboflavin metabolic process//membrane organization//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida GO:0046872//GO:0003993//GO:0005515 metal ion binding//acid phosphatase activity//protein binding GO:0016020//GO:0005576//GO:0030176 membrane//extracellular region//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.50990 BP_3 196.24 2.68 3820 189234149 XP_971128.2 773 5.8e-79 PREDICTED: uncharacterized protein LOC659761 [Tribolium castaneum]>gi|270002466|gb|EEZ98913.1| hypothetical protein TcasGA2_TC004532 [Tribolium castaneum] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q9VW97 195 2.5e-13 Possible lysine-specific histone demethylase 1 OS=Drosophila melanogaster GN=Su(var)3-3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.50994 BP_3 448.85 58.42 662 332375022 AEE62652.1 556 1.4e-54 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03955 NDUFAB1 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03955 Q94519 396 2.1e-37 Acyl carrier protein, mitochondrial OS=Drosophila melanogaster GN=mtacp1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-8309.50995 BP_3 42.75 0.37 5797 642935609 XP_008198080.1 4494 0.0e+00 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7C5 1453 5.1e-159 Phosphatidylinositide phosphatase SAC2 OS=Danio rerio GN=inpp5f PE=3 SV=1 PF02383//PF03092//PF06056 SacI homology domain//BT1 family//Putative ATPase subunit of terminase (gpP-like) GO:0006810//GO:0019069 transport//viral capsid assembly GO:0005524//GO:0042578 ATP binding//phosphoric ester hydrolase activity GO:0016021 integral component of membrane KOG1889 Putative phosphoinositide phosphatase Cluster-8309.50998 BP_3 48.78 0.52 4830 270013073 EFA09521.1 1113 2.7e-118 hypothetical protein TcasGA2_TC011623 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 Q5SWT3 770 6.7e-80 Solute carrier family 25 member 35 OS=Mus musculus GN=Slc25a35 PE=2 SV=2 PF07714//PF00069//PF01674 Protein tyrosine kinase//Protein kinase domain//Lipase (class 2) GO:0006468 protein phosphorylation GO:0016787//GO:0005524//GO:0004672 hydrolase activity//ATP binding//protein kinase activity -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.50999 BP_3 4.00 0.82 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51 BP_3 15.00 0.69 1341 270005976 EFA02424.1 1818 1.4e-200 hypothetical protein TcasGA2_TC008109 [Tribolium castaneum] 827025196 LM524968.1 52 7.42187e-16 Strongyloides venezuelensis genome assembly S_venezuelensis_HH1, scaffold SVE_scaffold0000001 K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q27802 1429 7.1e-157 Cytoplasmic dynein 2 heavy chain 1 OS=Tripneustes gratilla GN=DYH1B PE=2 SV=2 PF01926//PF07728//PF00005//PF00910//PF00437//PF00004 50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//ABC transporter//RNA helicase//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0006810 transport GO:0016887//GO:0005524//GO:0005525//GO:0003723//GO:0003724 ATPase activity//ATP binding//GTP binding//RNA binding//RNA helicase activity -- -- KOG3595 Dyneins, heavy chain Cluster-8309.51000 BP_3 107.00 28.88 470 642924825 XP_967668.2 489 6.0e-47 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 284 1.5e-24 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51003 BP_3 83.93 2.37 1999 189239183 XP_966847.2 1313 7.3e-142 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q7KT91 852 8.6e-90 Non-lysosomal glucosylceramidase OS=Drosophila melanogaster GN=CG33090 PE=1 SV=1 PF04685 Protein of unknown function, DUF608 GO:0006680//GO:0006807//GO:0006687//GO:0005975//GO:0006665 glucosylceramide catabolic process//nitrogen compound metabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process GO:0004348 glucosylceramidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.51004 BP_3 7.00 2.14 449 264667365 ACY71268.1 314 1.1e-26 ribosomal protein S23 [Chrysomela tremula] 769857176 XM_011641913.1 101 1.36454e-43 PREDICTED: Pogonomyrmex barbatus 40S ribosomal protein S23 (LOC105429139), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q6EV23 313 6.1e-28 40S ribosomal protein S23 OS=Papilio dardanus GN=RpS23 PE=2 SV=1 PF00164 Ribosomal protein S12/S23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1749 40S ribosomal protein S23 Cluster-8309.51006 BP_3 6.00 0.79 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51007 BP_3 161.83 0.87 9230 478249960 ENN70467.1 2128 1.1e-235 hypothetical protein YQE_12970, partial [Dendroctonus ponderosae] -- -- -- -- -- K10777 LIG4, DNL4 DNA ligase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10777 Q90YB1 1021 1.0e-108 DNA ligase 4 OS=Gallus gallus GN=LIG4 PE=2 SV=2 PF01068//PF11411//PF06814//PF04679//PF04675 ATP dependent DNA ligase domain//DNA ligase IV//Lung seven transmembrane receptor//ATP dependent DNA ligase C terminal region//DNA ligase N terminus GO:0006260//GO:0006310//GO:0006281 DNA replication//DNA recombination//DNA repair GO:0003677//GO:0005524//GO:0003910 DNA binding//ATP binding//DNA ligase (ATP) activity GO:0016021 integral component of membrane KOG0966 ATP-dependent DNA ligase IV Cluster-8309.51009 BP_3 168.83 2.17 4038 478261443 ENN80813.1 1898 2.2e-209 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] 462382197 APGK01021748.1 140 2.74019e-64 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence K02433 gatA, QRSL1 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02433 Q17H91 1361 1.6e-148 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Aedes aegypti GN=gatA PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.5101 BP_3 4.84 0.56 707 91092754 XP_973448.1 544 3.8e-53 PREDICTED: Werner Syndrome-like exonuclease [Tribolium castaneum]>gi|270014889|gb|EFA11337.1| hypothetical protein TcasGA2_TC010877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4PLB3 389 1.5e-36 Werner Syndrome-like exonuclease OS=Drosophila yakuba GN=WRNexo PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- -- -- Cluster-8309.51010 BP_3 387.72 3.78 5233 817052050 XP_012254225.1 1947 5.8e-215 PREDICTED: cGMP-dependent 3',5'-cyclic phosphodiesterase-like isoform X2 [Athalia rosae] -- -- -- -- -- K18283 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K18283 P14099 1564 6.2e-172 cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Bos taurus GN=PDE2A PE=1 SV=2 PF00233//PF01590//PF13492//PF05699//PF11590//PF13185//PF00494 3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain//hAT family C-terminal dimerisation region//DNA polymerase catalytic subunit Pol//GAF domain//Squalene/phytoene synthase GO:0051252//GO:0009058//GO:0006260//GO:0006144//GO:0007165 regulation of RNA metabolic process//biosynthetic process//DNA replication//purine nucleobase metabolic process//signal transduction GO:0004523//GO:0046983//GO:0003887//GO:0005515//GO:0004114//GO:0016740 RNA-DNA hybrid ribonuclease activity//protein dimerization activity//DNA-directed DNA polymerase activity//protein binding//3',5'-cyclic-nucleotide phosphodiesterase activity//transferase activity GO:0042575 DNA polymerase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.51011 BP_3 102.37 2.21 2529 270010170 EFA06618.1 643 4.5e-64 hypothetical protein TcasGA2_TC009536 [Tribolium castaneum] -- -- -- -- -- K11343 MRGBP MRG-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11343 Q9NV56 222 1.2e-16 MRG/MORF4L-binding protein OS=Homo sapiens GN=MRGBP PE=1 SV=1 PF07904//PF02535//PF02724 Chromatin modification-related protein EAF7//ZIP Zinc transporter//CDC45-like protein GO:0006355//GO:0030001//GO:0055085//GO:0006270 regulation of transcription, DNA-templated//metal ion transport//transmembrane transport//DNA replication initiation GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005634//GO:0043189 membrane//nucleus//H4/H2A histone acetyltransferase complex -- -- Cluster-8309.51015 BP_3 132.95 1.93 3608 646724190 KDR24525.1 1729 7.6e-190 WD repeat-containing protein 40A, partial [Zootermopsis nevadensis] -- -- -- -- -- K11803 WDR40A WD repeat-containing protein 40A http://www.genome.jp/dbget-bin/www_bget?ko:K11803 Q4R3J7 828 9.4e-87 DDB1- and CUL4-associated factor 12 OS=Macaca fascicularis GN=DCAF12 PE=2 SV=1 PF00400//PF03178 WD domain, G-beta repeat//CPSF A subunit region -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.51016 BP_3 1050.11 23.52 2444 642938254 XP_008198131.1 1462 4.7e-159 PREDICTED: disintegrin and metalloproteinase domain-containing protein 10 isoform X2 [Tribolium castaneum] 642938253 XM_008199909.1 218 7.20304e-108 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X2, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 Q8JIY1 635 1.5e-64 Disintegrin and metalloproteinase domain-containing protein 10 OS=Xenopus laevis GN=adam10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.51018 BP_3 38.63 0.74 2791 91090155 XP_972292.1 566 4.2e-55 PREDICTED: uncharacterized protein LOC661009 [Tribolium castaneum]>gi|270013490|gb|EFA09938.1| hypothetical protein TcasGA2_TC012091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05823//PF01284 Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Membrane-associating domain -- -- GO:0008289 lipid binding GO:0016020 membrane -- -- Cluster-8309.51020 BP_3 3.00 2.31 349 746843684 XP_011052079.1 152 5.3e-08 PREDICTED: uncharacterized protein LOC105144710, partial [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02543//PF00816 Carbamoyltransferase N-terminus//H-NS histone family GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0003677//GO:0003824 DNA binding//catalytic activity GO:0005622 intracellular -- -- Cluster-8309.51025 BP_3 39.24 1.75 1372 642915588 XP_008190677.1 1743 6.9e-192 PREDICTED: tyrosine-protein phosphatase Lar isoform X3 [Tribolium castaneum] -- -- -- -- -- K06777 PTPRD receptor-type tyrosine-protein phosphatase delta http://www.genome.jp/dbget-bin/www_bget?ko:K06777 P16621 1339 2.0e-146 Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51027 BP_3 7.00 12.61 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5103 BP_3 7.53 0.39 1219 242003872 XP_002422893.1 390 4.7e-35 vacuolar amino acid transporter, putative [Pediculus humanus corporis]>gi|212505775|gb|EEB10155.1| vacuolar amino acid transporter, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q8IZM9 128 4.7e-06 Probable sodium-coupled neutral amino acid transporter 6 OS=Homo sapiens GN=SLC38A6 PE=1 SV=2 PF03222 Tryptophan/tyrosine permease family GO:0003333 amino acid transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51031 BP_3 218.38 3.91 2982 642939887 XP_008200200.1 2712 6.5e-304 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12616 EDC4 enhancer of mRNA-decapping protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12616 Q1LUT1 565 2.4e-56 Enhancer of mRNA-decapping protein 4 OS=Danio rerio GN=edc4 PE=3 SV=1 PF07464//PF08236//PF06152//PF01442//PF04216 Apolipophorin-III precursor (apoLp-III)//SRI (Set2 Rpb1 interacting) domain//Phage minor capsid protein 2//Apolipoprotein A1/A4/E domain//Protein involved in formate dehydrogenase formation GO:0006869//GO:0034968//GO:0042157//GO:0006554//GO:0006355//GO:0006479 lipid transport//histone lysine methylation//lipoprotein metabolic process//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005198//GO:0008289//GO:0018024 structural molecule activity//lipid binding//histone-lysine N-methyltransferase activity GO:0019028//GO:0005737//GO:0005576//GO:0005694 viral capsid//cytoplasm//extracellular region//chromosome KOG1916 Nuclear protein, contains WD40 repeats Cluster-8309.51034 BP_3 34.09 0.83 2272 642915063 XP_008190394.1 983 1.5e-103 PREDICTED: acyl-CoA dehydrogenase family member 9, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZN5 435 2.2e-41 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 PF00763//PF00441//PF02771//PF02770 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0055114//GO:0006118//GO:0046487//GO:0009396//GO:0008152 oxidation-reduction process//obsolete electron transport//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//metabolic process GO:0016627//GO:0050660//GO:0004488//GO:0003995//GO:0003824 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//methylenetetrahydrofolate dehydrogenase (NADP+) activity//acyl-CoA dehydrogenase activity//catalytic activity -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.51037 BP_3 85.71 1.13 3952 478251563 ENN72025.1 1587 2.4e-173 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RGJ5 846 8.4e-89 CWF19-like protein 1 OS=Danio rerio GN=cwf19l1 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.51038 BP_3 1011.64 31.35 1847 646226754 CDF77374.1 676 4.9e-68 CD63 protein [Tenebrio molitor] 817053829 XM_012408690.1 49 4.79092e-14 PREDICTED: Athalia rosae CD63 antigen-like (LOC105690669), mRNA K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q6GMK6 250 5.1e-20 Tetraspanin-9 OS=Danio rerio GN=tspan9 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.51039 BP_3 268.00 4.38 3240 642936007 XP_008198265.1 2144 5.2e-238 PREDICTED: uncharacterized protein LOC662355 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17725 ETHE1 sulfur dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K17725 -- -- -- -- PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51041 BP_3 28.68 0.53 2878 642920046 XP_975305.2 1015 3.8e-107 PREDICTED: kielin/chordin-like protein [Tribolium castaneum]>gi|270005328|gb|EFA01776.1| hypothetical protein TcasGA2_TC007377 [Tribolium castaneum] -- -- -- -- -- K11169 DHRS13 dehydrogenase/reductase SDR family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11169 Q6UX07 197 1.1e-13 Dehydrogenase/reductase SDR family member 13 OS=Homo sapiens GN=DHRS13 PE=2 SV=1 PF00106//PF02088 short chain dehydrogenase//Ornatin GO:0007155//GO:0008152//GO:0030193 cell adhesion//metabolic process//regulation of blood coagulation GO:0016491 oxidoreductase activity GO:0005576 extracellular region KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.51044 BP_3 68.68 1.90 2031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05320 Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.51045 BP_3 134.00 1.10 6160 642929931 XP_008196030.1 3940 0.0e+00 PREDICTED: inactive dipeptidyl peptidase 10 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 C5FYZ3 716 1.6e-73 Probable dipeptidyl-aminopeptidase B OS=Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) GN=DAPB PE=3 SV=1 PF00930//PF05739//PF02129//PF07859//PF02230//PF03403//PF00326 Dipeptidyl peptidase IV (DPP IV) N-terminal region//SNARE domain//X-Pro dipeptidyl-peptidase (S15 family)//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Platelet-activating factor acetylhydrolase, isoform II//Prolyl oligopeptidase family GO:0046486//GO:0016042//GO:0006508//GO:0008152 glycerolipid metabolic process//lipid catabolic process//proteolysis//metabolic process GO:0008236//GO:0005515//GO:0003847//GO:0016787 serine-type peptidase activity//protein binding//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG2100 Dipeptidyl aminopeptidase Cluster-8309.51048 BP_3 39.04 1.41 1623 91080473 XP_970438.1 562 7.2e-55 PREDICTED: mitochondrial inner membrane protease subunit 1 [Tribolium castaneum]>gi|270005561|gb|EFA02009.1| hypothetical protein TcasGA2_TC007631 [Tribolium castaneum] -- -- -- -- -- K09647 IMP1 mitochondrial inner membrane protease subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09647 Q96LU5 398 3.1e-37 Mitochondrial inner membrane protease subunit 1 OS=Homo sapiens GN=IMMP1L PE=2 SV=1 -- -- GO:0006508 proteolysis GO:0008236 serine-type peptidase activity GO:0016021 integral component of membrane KOG0171 Mitochondrial inner membrane protease, subunit IMP1 Cluster-8309.51049 BP_3 16.91 0.70 1457 91080473 XP_970438.1 524 1.6e-50 PREDICTED: mitochondrial inner membrane protease subunit 1 [Tribolium castaneum]>gi|270005561|gb|EFA02009.1| hypothetical protein TcasGA2_TC007631 [Tribolium castaneum] -- -- -- -- -- K09647 IMP1 mitochondrial inner membrane protease subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09647 Q96LU5 360 7.0e-33 Mitochondrial inner membrane protease subunit 1 OS=Homo sapiens GN=IMMP1L PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0171 Mitochondrial inner membrane protease, subunit IMP1 Cluster-8309.51051 BP_3 32.76 0.79 2295 861599125 KMQ83546.1 252 9.0e-19 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51052 BP_3 108.32 1.14 4860 478255815 ENN76023.1 1513 1.1e-164 hypothetical protein YQE_07399, partial [Dendroctonus ponderosae] -- -- -- -- -- K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q9Z136 486 5.7e-47 Hamartin OS=Rattus norvegicus GN=Tsc1 PE=1 SV=1 PF06005 Protein of unknown function (DUF904) GO:0000917//GO:0043093 barrier septum assembly//FtsZ-dependent cytokinesis -- -- GO:0005737 cytoplasm KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.51057 BP_3 42.12 1.32 1827 91089563 XP_971820.1 657 7.8e-66 PREDICTED: diphthamide biosynthesis protein 7 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q9CYU6 373 2.7e-34 Diphthine methyltransferase OS=Mus musculus GN=Dph7 PE=2 SV=1 PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.51058 BP_3 85.82 1.37 3318 91089563 XP_971820.1 657 1.4e-65 PREDICTED: diphthamide biosynthesis protein 7 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q9CYU6 373 5.0e-34 Diphthine methyltransferase OS=Mus musculus GN=Dph7 PE=2 SV=1 PF01596//PF00322//PF07127//PF06874 O-methyltransferase//Endothelin family//Late nodulin protein//Firmicute fructose-1,6-bisphosphatase GO:0019229//GO:0006098//GO:0006096//GO:0006013//GO:0006000//GO:0015976//GO:0006094//GO:0009878 regulation of vasoconstriction//pentose-phosphate shunt//glycolytic process//mannose metabolic process//fructose metabolic process//carbon utilization//gluconeogenesis//nodule morphogenesis GO:0042132//GO:0008171//GO:0046872 fructose 1,6-bisphosphate 1-phosphatase activity//O-methyltransferase activity//metal ion binding GO:0005576 extracellular region -- -- Cluster-8309.51059 BP_3 31.87 0.71 2452 270012598 EFA09046.1 325 3.3e-27 hypothetical protein TcasGA2_TC006759 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q55C80 211 2.2e-15 Diphthine methyltransferase homolog OS=Dictyostelium discoideum GN=wdr85 PE=3 SV=1 PF04137//PF05699 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//hAT family C-terminal dimerisation region GO:0055114 oxidation-reduction process GO:0016671//GO:0003756//GO:0046983 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//protein disulfide isomerase activity//protein dimerization activity GO:0005783 endoplasmic reticulum KOG0280 Uncharacterized conserved protein Cluster-8309.51060 BP_3 76.95 1.21 3354 768413304 XP_011568765.1 398 1.5e-35 PREDICTED: uncharacterized protein LOC105398382 [Plutella xylostella] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q9BTV6 216 8.0e-16 Diphthine methyltransferase OS=Homo sapiens GN=DPH7 PE=1 SV=2 PF06874//PF01596//PF00322//PF07127 Firmicute fructose-1,6-bisphosphatase//O-methyltransferase//Endothelin family//Late nodulin protein GO:0006096//GO:0006098//GO:0019229//GO:0009878//GO:0006094//GO:0015976//GO:0006000//GO:0006013 glycolytic process//pentose-phosphate shunt//regulation of vasoconstriction//nodule morphogenesis//gluconeogenesis//carbon utilization//fructose metabolic process//mannose metabolic process GO:0008171//GO:0042132//GO:0046872 O-methyltransferase activity//fructose 1,6-bisphosphate 1-phosphatase activity//metal ion binding GO:0005576 extracellular region -- -- Cluster-8309.51061 BP_3 30.11 0.47 3407 91089563 XP_971820.1 517 2.5e-49 PREDICTED: diphthamide biosynthesis protein 7 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q9BTV6 309 1.3e-26 Diphthine methyltransferase OS=Homo sapiens GN=DPH7 PE=1 SV=2 PF06874//PF01596//PF00322 Firmicute fructose-1,6-bisphosphatase//O-methyltransferase//Endothelin family GO:0006096//GO:0006098//GO:0019229//GO:0006094//GO:0015976//GO:0006013//GO:0006000 glycolytic process//pentose-phosphate shunt//regulation of vasoconstriction//gluconeogenesis//carbon utilization//mannose metabolic process//fructose metabolic process GO:0008171//GO:0042132 O-methyltransferase activity//fructose 1,6-bisphosphate 1-phosphatase activity GO:0005576 extracellular region -- -- Cluster-8309.51062 BP_3 18.13 3.50 541 270012598 EFA09046.1 338 2.2e-29 hypothetical protein TcasGA2_TC006759 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q55C80 230 3.1e-18 Diphthine methyltransferase homolog OS=Dictyostelium discoideum GN=wdr85 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0280 Uncharacterized conserved protein Cluster-8309.51064 BP_3 12.81 0.78 1087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51069 BP_3 1.00 2.12 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5107 BP_3 12.32 0.33 2103 646693425 KDR07697.1 969 5.9e-102 Proton-coupled amino acid transporter 4 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q4KL91 170 1.1e-10 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 PF00955//PF03222//PF03402//PF03845 HCO3- transporter family//Tryptophan/tyrosine permease family//Vomeronasal organ pheromone receptor family, V1R//Spore germination protein GO:0007606//GO:0006820//GO:0019236//GO:0007186//GO:0009847//GO:0003333 sensory perception of chemical stimulus//anion transport//response to pheromone//G-protein coupled receptor signaling pathway//spore germination//amino acid transmembrane transport GO:0016503 pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.51072 BP_3 295.57 2.78 5416 642936622 XP_008198510.1 3086 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X2 [Tribolium castaneum] 642936623 XM_008200289.1 120 4.83309e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.4e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF02346//PF01166 Chordopoxvirus multifunctional envelope protein A27//TSC-22/dip/bun family GO:0006355//GO:0019064 regulation of transcription, DNA-templated//fusion of virus membrane with host plasma membrane GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.51073 BP_3 16.00 1.59 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51074 BP_3 154.67 6.73 1400 642912272 XP_008200632.1 381 6.0e-34 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90WD8 219 1.5e-16 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.51076 BP_3 19.42 0.50 2149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51077 BP_3 21.60 0.61 2003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51081 BP_3 61.84 0.71 4510 642926793 XP_008195018.1 4220 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 73 5.38635e-27 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2506 3.1e-281 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF13606//PF00651//PF00023//PF01068 Ankyrin repeat//BTB/POZ domain//Ankyrin repeat//ATP dependent DNA ligase domain GO:0006281//GO:0006310//GO:0006260 DNA repair//DNA recombination//DNA replication GO:0005515//GO:0003910//GO:0005524 protein binding//DNA ligase (ATP) activity//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.51082 BP_3 221.10 2.91 3952 478256893 ENN77062.1 359 6.0e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 6.1e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF01844//PF16622//PF02150//PF07975//PF13465//PF00096 HNH endonuclease//zinc-finger C2H2-type//RNA polymerases M/15 Kd subunit//TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006351//GO:0006281//GO:0006144//GO:0006206 transcription, DNA-templated//DNA repair//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0004519//GO:0003676//GO:0008270//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//endonuclease activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.51084 BP_3 36.22 1.49 1463 662192693 XP_008469216.1 150 3.8e-07 PREDICTED: uncharacterized protein LOC103506596 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51085 BP_3 15.47 0.40 2143 662192693 XP_008469216.1 150 5.6e-07 PREDICTED: uncharacterized protein LOC103506596 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51087 BP_3 116.65 2.01 3082 270003283 EEZ99730.1 288 8.1e-23 hypothetical protein TcasGA2_TC002499 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 -- -- -- -- PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.51090 BP_3 46.55 1.31 2000 642921483 XP_008192888.1 951 6.9e-100 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51091 BP_3 176.17 6.41 1616 642921483 XP_008192888.1 1043 1.2e-110 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY1 209 2.5e-15 Monocarboxylate transporter 9 OS=Homo sapiens GN=SLC16A9 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.51092 BP_3 321.25 3.00 5457 189238580 XP_971286.2 2127 8.1e-236 PREDICTED: protein mothers against dpp-like [Tribolium castaneum] 826414663 XM_012666571.1 155 1.70266e-72 PREDICTED: Monomorium pharaonis protein mothers against dpp (LOC105828307), transcript variant X2, mRNA K04676 SMAD1 mothers against decapentaplegic homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04676 P42003 1912 2.9e-212 Protein mothers against dpp OS=Drosophila melanogaster GN=Mad PE=1 SV=1 PF03165//PF01272//PF10401//PF03166 MH1 domain//Transcription elongation factor, GreA/GreB, C-term//Interferon-regulatory factor 3//MH2 domain GO:0032784//GO:0006355 regulation of DNA-templated transcription, elongation//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.51094 BP_3 220.29 1.61 6883 642923817 XP_001816010.2 3150 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 2.62763e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q9NQC7 1133 7.7e-122 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens GN=CYLD PE=1 SV=1 PF00443//PF07297//PF01529//PF04451 Ubiquitin carboxyl-terminal hydrolase//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//DHHC palmitoyltransferase//Large eukaryotic DNA virus major capsid protein GO:0009059//GO:0016579 macromolecule biosynthetic process//protein deubiquitination GO:0036459//GO:0008270//GO:0005198 ubiquitinyl hydrolase activity//zinc ion binding//structural molecule activity GO:0019028//GO:0030176 viral capsid//integral component of endoplasmic reticulum membrane KOG2257 N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis Cluster-8309.51095 BP_3 516.37 3.81 6818 642923817 XP_001816010.2 3150 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 2.60268e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q9NQC7 1133 7.6e-122 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens GN=CYLD PE=1 SV=1 PF07297//PF00443//PF01529//PF04451 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Ubiquitin carboxyl-terminal hydrolase//DHHC palmitoyltransferase//Large eukaryotic DNA virus major capsid protein GO:0009059//GO:0016579 macromolecule biosynthetic process//protein deubiquitination GO:0036459//GO:0008270//GO:0005198 ubiquitinyl hydrolase activity//zinc ion binding//structural molecule activity GO:0019028//GO:0030176 viral capsid//integral component of endoplasmic reticulum membrane KOG2257 N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis Cluster-8309.51097 BP_3 285.74 13.50 1312 478253679 ENN73981.1 424 5.8e-39 hypothetical protein YQE_09436, partial [Dendroctonus ponderosae]>gi|546684423|gb|ERL94066.1| hypothetical protein D910_11349 [Dendroctonus ponderosae] -- -- -- -- -- K03861 PIGP, GPI19, DSCR5 phosphatidylinositol glycan, class P http://www.genome.jp/dbget-bin/www_bget?ko:K03861 Q9JHG1 231 5.7e-18 Phosphatidylinositol N-acetylglucosaminyltransferase subunit P OS=Mus musculus GN=Pigp PE=2 SV=1 PF07297//PF04451//PF01529 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Large eukaryotic DNA virus major capsid protein//DHHC palmitoyltransferase GO:0009059 macromolecule biosynthetic process GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0019028//GO:0030176 viral capsid//integral component of endoplasmic reticulum membrane KOG2257 N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis Cluster-8309.51098 BP_3 287.63 5.26 2928 642921224 XP_008192769.1 1615 1.0e-176 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921235 XM_008194553.1 303 4.84731e-155 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 651 2.5e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF13606//PF00023//PF14604//PF00018 Ankyrin repeat//Ankyrin repeat//Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.51104 BP_3 232.88 1.57 7463 642940390 XP_008200542.1 735 2.9e-74 PREDICTED: chitin deacetylase 5 isoform X3 [Tribolium castaneum] 642940399 XM_008202325.1 70 4.15822e-25 PREDICTED: Tribolium castaneum chitin deacetylase 5 (Cda5), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF01607//PF01061 Chitin binding Peritrophin-A domain//ABC-2 type transporter GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.51105 BP_3 4.00 20.11 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51106 BP_3 51.05 2.34 1341 270015218 EFA11666.1 601 1.8e-59 hypothetical protein TcasGA2_TC008530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW3 280 1.2e-23 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.51108 BP_3 3.00 0.31 757 195979063 ACG63697.1 1003 2.4e-106 myosin heavy chain [Gammarus duebeni] 410509305 AB758441.1 217 7.77768e-108 Penaeus monodon MYH1 mRNA for myosin heavy chain type 1, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 921 3.2e-98 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0003774//GO:0005524 motor activity//ATP binding GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.51111 BP_3 25.29 0.66 2140 343183155 BAK61430.1 2733 1.7e-306 myosin heavy chain type b [Marsupenaeus japonicus] 343183154 AB613206.1 785 0 Marsupenaeus japonicus MYHb mRNA for myosin heavy chain type b, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2430 9.6e-273 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF01059//PF00063//PF02736//PF04799 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Myosin head (motor domain)//Myosin N-terminal SH3-like domain//fzo-like conserved region GO:0008053//GO:0055114//GO:0006120 mitochondrial fusion//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone GO:0003774//GO:0005524//GO:0003924 motor activity//ATP binding//GTPase activity GO:0005741//GO:0016021//GO:0016459 mitochondrial outer membrane//integral component of membrane//myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.51114 BP_3 6.00 0.42 978 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51115 BP_3 27.00 26.86 332 478257525 ENN77680.1 162 3.5e-09 hypothetical protein YQE_05831, partial [Dendroctonus ponderosae]>gi|546677868|gb|ERL88620.1| hypothetical protein D910_06005 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51120 BP_3 294.00 36.31 682 478256423 ENN76610.1 428 1.0e-39 hypothetical protein YQE_06868, partial [Dendroctonus ponderosae] -- -- -- -- -- K17292 TBCA tubulin-specific chaperone A http://www.genome.jp/dbget-bin/www_bget?ko:K17292 Q6PEC1 330 9.8e-30 Tubulin-specific chaperone A OS=Rattus norvegicus GN=Tbca PE=1 SV=1 PF02970 Tubulin binding cofactor A GO:0007021 tubulin complex assembly GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0045298 tubulin complex KOG3470 Beta-tubulin folding cofactor A Cluster-8309.51121 BP_3 15.90 1.05 1021 554879053 XP_005949345.1 151 2.0e-07 PREDICTED: low-density lipoprotein receptor-related protein 2-like [Haplochromis burtoni] -- -- -- -- -- -- -- -- -- P98164 140 1.6e-07 Low-density lipoprotein receptor-related protein 2 OS=Homo sapiens GN=LRP2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.51124 BP_3 28.34 0.68 2301 91087367 XP_975633.1 890 9.4e-93 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XJA3 343 1.0e-30 Protein PRRC1 OS=Danio rerio GN=prrc1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51126 BP_3 39.34 0.84 2550 642926818 XP_001810169.2 1787 1.0e-196 PREDICTED: uncharacterized protein LOC100142170 isoform X1 [Tribolium castaneum] 642926819 XM_008196805.1 195 4.59036e-95 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096 Altered inheritance of mitochondria protein 3 GO:0051016 barbed-end actin filament capping -- -- GO:0030479 actin cortical patch -- -- Cluster-8309.51127 BP_3 321.00 23.72 944 478257864 ENN78006.1 605 4.3e-60 hypothetical protein YQE_05526, partial [Dendroctonus ponderosae]>gi|546674575|gb|ERL85928.1| hypothetical protein D910_03343 [Dendroctonus ponderosae] -- -- -- -- -- K17432 MRPL51 large subunit ribosomal protein L51 http://www.genome.jp/dbget-bin/www_bget?ko:K17432 Q29PG4 514 6.3e-51 39S ribosomal protein L51, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL51 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4045 Uncharacterized conserved protein Cluster-8309.51128 BP_3 158.98 1.34 6025 646720734 KDR22356.1 2392 1.7e-266 Protein melted [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9VS24 1951 9.5e-217 Protein melted OS=Drosophila melanogaster GN=melt PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3723 PH domain protein Melted Cluster-8309.51129 BP_3 59.67 0.89 3513 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 6.8e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF05504//PF00233//PF09771//PF00989//PF00072 Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188//PAS fold//Response regulator receiver domain GO:0009847//GO:0006355//GO:0006144//GO:0007165//GO:0035307//GO:0000160 spore germination//regulation of transcription, DNA-templated//purine nucleobase metabolic process//signal transduction//positive regulation of protein dephosphorylation//phosphorelay signal transduction system GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.51132 BP_3 3.00 0.39 662 470012454 AGI03918.1 281 1.1e-22 60S ribosomal protein L4-like protein, partial [Leptinotarsa decemlineata] -- -- -- -- -- K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P09180 192 9.6e-14 60S ribosomal protein L4 OS=Drosophila melanogaster GN=RpL4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-8309.51133 BP_3 29.00 1.83 1054 805766866 XP_012135376.1 388 7.0e-35 PREDICTED: uncharacterized protein LOC105661843 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.51134 BP_3 11.09 0.45 1469 270004508 EFA00956.1 297 3.5e-24 hypothetical protein TcasGA2_TC003866 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51138 BP_3 749.56 10.47 3741 642930503 XP_008196431.1 1202 1.0e-128 PREDICTED: uncharacterized protein LOC663881 [Tribolium castaneum]>gi|270010742|gb|EFA07190.1| hypothetical protein TcasGA2_TC010196 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- -- -- Cluster-8309.51139 BP_3 654.55 6.01 5545 546676831 ERL87777.1 1250 4.1e-134 hypothetical protein D910_05166 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DCD5 235 8.3e-18 Tight junction-associated protein 1 OS=Mus musculus GN=Tjap1 PE=1 SV=1 PF01890 Cobalamin synthesis G C-terminus GO:0009236 cobalamin biosynthetic process -- -- -- -- -- -- Cluster-8309.5114 BP_3 40.10 0.61 3445 642915798 XP_008200082.1 3736 0.0e+00 PREDICTED: discoidin domain-containing receptor 2-like [Tribolium castaneum] -- -- -- -- -- K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 618 2.0e-62 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1094 Discoidin domain receptor DDR1 Cluster-8309.51140 BP_3 31.19 0.78 2214 189237080 XP_969040.2 1869 2.7e-206 PREDICTED: E3 ubiquitin-protein ligase parkin [Tribolium castaneum] -- -- -- -- -- K04556 PARK2 parkin http://www.genome.jp/dbget-bin/www_bget?ko:K04556 Q9JK66 872 4.5e-92 E3 ubiquitin-protein ligase parkin OS=Rattus norvegicus GN=Park2 PE=1 SV=1 PF00240//PF15965 Ubiquitin family//TRAF-like zinc-finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0006 E3 ubiquitin-protein ligase (Parkin protein) Cluster-8309.51141 BP_3 37.01 0.85 2384 642915063 XP_008190394.1 636 2.8e-63 PREDICTED: acyl-CoA dehydrogenase family member 9, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZN5 252 3.8e-20 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 PF09057//PF00926//PF02770//PF02771 Second Mitochondria-derived Activator of Caspases//3,4-dihydroxy-2-butanone 4-phosphate synthase//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0006915//GO:0006118//GO:0006919//GO:0009231//GO:0008152 oxidation-reduction process//apoptotic process//obsolete electron transport//activation of cysteine-type endopeptidase activity involved in apoptotic process//riboflavin biosynthetic process//metabolic process GO:0016627//GO:0050660//GO:0003995//GO:0008686 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//3,4-dihydroxy-2-butanone-4-phosphate synthase activity GO:0005739 mitochondrion KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.51144 BP_3 9.00 0.49 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51146 BP_3 200.32 3.16 3349 91080057 XP_973322.1 1545 1.5e-168 PREDICTED: GDP-mannose 4,6 dehydratase [Tribolium castaneum]>gi|270004634|gb|EFA01082.1| hypothetical protein TcasGA2_TC004005 [Tribolium castaneum] 817222766 XM_012431305.1 132 6.35185e-60 PREDICTED: Orussus abietinus GDP-mannose 4,6 dehydratase-like (LOC105703151), mRNA K01711 gmd, GMDS GDPmannose 4,6-dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01711 Q9VMW9 1386 1.7e-151 GDP-mannose 4,6 dehydratase OS=Drosophila melanogaster GN=Gmd PE=1 SV=2 PF04814//PF01370 Hepatocyte nuclear factor 1 (HNF-1), N terminus//NAD dependent epimerase/dehydratase family GO:0009298//GO:0006012//GO:0019673//GO:0045893//GO:0006000 GDP-mannose biosynthetic process//galactose metabolic process//GDP-mannose metabolic process//positive regulation of transcription, DNA-templated//fructose metabolic process GO:0050662//GO:0003824//GO:0000166//GO:0008446 coenzyme binding//catalytic activity//nucleotide binding//GDP-mannose 4,6-dehydratase activity GO:0005634//GO:0005622 nucleus//intracellular KOG1372 GDP-mannose 4,6 dehydratase Cluster-8309.51148 BP_3 528.55 20.06 1562 642924915 XP_008194095.1 1347 6.5e-146 PREDICTED: neprilysin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 O16796 719 1.8e-74 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.51150 BP_3 112.17 0.76 7383 189234456 XP_968035.2 3830 0.0e+00 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Tribolium castaneum]>gi|270001744|gb|EEZ98191.1| hypothetical protein TcasGA2_TC000620 [Tribolium castaneum] 831497549 XM_012853965.1 227 2.17964e-112 PREDICTED: Fundulus heteroclitus phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3), mRNA K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00914 Q6PF93 2695 6.2e-303 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Mus musculus GN=Pik3c3 PE=1 SV=1 PF00454 Phosphatidylinositol 3- and 4-kinase GO:0036092//GO:0046854//GO:0048015 phosphatidylinositol-3-phosphate biosynthetic process//phosphatidylinositol phosphorylation//phosphatidylinositol-mediated signaling GO:0016303//GO:0005524//GO:0016773 1-phosphatidylinositol-3-kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0906 Phosphatidylinositol 3-kinase VPS34, involved in signal transduction Cluster-8309.51153 BP_3 1.00 3.93 271 642089788 CDQ82427.1 332 5.6e-29 unnamed protein product [Oncorhynchus mykiss] 393395827 JQ824131.1 265 5.3134e-135 Scylla paramamosain elongation factor 2 mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 P29691 317 1.3e-28 Elongation factor 2 OS=Caenorhabditis elegans GN=eef-2 PE=2 SV=4 PF01926 50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8309.51159 BP_3 7.00 0.43 1068 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00682 HMGL-like -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.51160 BP_3 14.13 0.33 2335 189237572 XP_974818.2 1066 3.7e-113 PREDICTED: uncharacterized protein LOC663689 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13014//PF04999//PF00013//PF07650 KH domain//Cell division protein FtsL//KH domain//KH domain GO:0007049//GO:0051301 cell cycle//cell division GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.51161 BP_3 341.95 3.63 4827 546687608 ERL96229.1 1695 8.9e-186 hypothetical protein D910_01506 [Dendroctonus ponderosae]>gi|546687612|gb|ERL96230.1| hypothetical protein D910_01507 [Dendroctonus ponderosae] 817204838 XM_012422887.1 468 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X5, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1555 6.3e-171 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.51165 BP_3 12153.28 82.44 7397 642918516 XP_008191506.1 2857 0.0e+00 PREDICTED: angiopoietin-4 [Tribolium castaneum] 755982309 XM_011311561.1 246 5.98645e-123 PREDICTED: Fopius arisanus angiopoietin-related protein 2 (LOC105270540), mRNA -- -- -- -- Q9U8W7 556 6.7e-55 Techylectin-5B OS=Tachypleus tridentatus PE=1 SV=1 PF08336//PF05615//PF04111//PF00137//PF04513//PF08702 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Tho complex subunit 7//Autophagy protein Apg6//ATP synthase subunit C//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family GO:0006914//GO:0051258//GO:0018401//GO:0007165//GO:0006525//GO:0015992//GO:0055114//GO:0006560//GO:0015991//GO:0006397//GO:0030168 autophagy//protein polymerization//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//signal transduction//arginine metabolic process//proton transport//oxidation-reduction process//proline metabolic process//ATP hydrolysis coupled proton transport//mRNA processing//platelet activation GO:0005198//GO:0016702//GO:0005102//GO:0015078//GO:0004656//GO:0030674 structural molecule activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//receptor binding//hydrogen ion transmembrane transporter activity//procollagen-proline 4-dioxygenase activity//protein binding, bridging GO:0033177//GO:0019028//GO:0005577//GO:0000445//GO:0005783//GO:0019031 proton-transporting two-sector ATPase complex, proton-transporting domain//viral capsid//fibrinogen complex//THO complex part of transcription export complex//endoplasmic reticulum//viral envelope KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.51174 BP_3 220.29 1.20 9162 642918201 XP_008191408.1 10448 0.0e+00 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918206 XM_008193189.1 808 0 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X4, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 Q15911 1905 3.1e-211 Zinc finger homeobox protein 3 OS=Homo sapiens GN=ZFHX3 PE=1 SV=2 PF00096//PF04988//PF00046//PF13912//PF01435//PF05920//PF13411 Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//Homeobox domain//C2H2-type zinc finger//Peptidase family M48//Homeobox KN domain//MerR HTH family regulatory protein GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0004222//GO:0003677//GO:0046872 metalloendopeptidase activity//DNA binding//metal ion binding GO:0005634 nucleus KOG1146 Homeobox protein Cluster-8309.51176 BP_3 14893.69 1637.92 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51177 BP_3 394.74 2.76 7178 589968018 XP_006996507.1 370 5.8e-32 PREDICTED: zinc finger protein 431-like [Peromyscus maniculatus bairdii] -- -- -- -- -- -- -- -- -- Q9UJN7 345 1.9e-30 Zinc finger protein 391 OS=Homo sapiens GN=ZNF391 PE=2 SV=2 PF02724//PF13912//PF09606//PF08452//PF13465//PF00096//PF00508 CDC45-like protein//C2H2-type zinc finger//ARC105 or Med15 subunit of Mediator complex non-fungal//DNA polymerase family B exonuclease domain, N-terminal//Zinc-finger double domain//Zinc finger, C2H2 type//E2 (early) protein, N terminal GO:0006260//GO:0006357//GO:0006355//GO:0016032//GO:0006275//GO:0006270 DNA replication//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//viral process//regulation of DNA replication//DNA replication initiation GO:0046872//GO:0001104//GO:0003887 metal ion binding//RNA polymerase II transcription cofactor activity//DNA-directed DNA polymerase activity GO:0016592//GO:0042575 mediator complex//DNA polymerase complex -- -- Cluster-8309.51178 BP_3 141.53 3.52 2232 672017838 XP_008773853.1 392 5.1e-35 PREDICTED: zinc finger protein 431-like isoform X1 [Rattus norvegicus] -- -- -- -- -- -- -- -- -- P51522 368 1.3e-33 Zinc finger protein 83 OS=Homo sapiens GN=ZNF83 PE=2 SV=3 PF11744//PF00096//PF13465//PF13912//PF02724//PF01428 Aluminium activated malate transporter//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//CDC45-like protein//AN1-like Zinc finger GO:0015743//GO:0006270 malate transport//DNA replication initiation GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.51179 BP_3 134.58 1.16 5889 189239140 XP_001806913.1 1267 4.6e-136 PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|642928372|ref|XP_008192716.1| PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|270010787|gb|EFA07235.1| hypothetical protein TcasGA2_TC010592 [Tribolium castaneum] 657809175 XM_008333639.1 51 1.19594e-14 PREDICTED: Cynoglossus semilaevis TSC22 domain family protein 2-like (LOC103395840), transcript variant X2, mRNA -- -- -- -- Q24523 204 3.5e-14 Protein bunched, class 2/F/G isoform OS=Drosophila melanogaster GN=bun PE=2 SV=4 PF04977//PF06156//PF01486//PF00170//PF06005//PF01166//PF07926//PF04799//PF11365//PF00038//PF07716 Septum formation initiator//Protein of unknown function (DUF972)//K-box region//bZIP transcription factor//Protein of unknown function (DUF904)//TSC-22/dip/bun family//TPR/MLP1/MLP2-like protein//fzo-like conserved region//Protein of unknown function (DUF3166)//Intermediate filament protein//Basic region leucine zipper GO:0043093//GO:0000917//GO:0008053//GO:0010506//GO:0007049//GO:0006260//GO:0006355//GO:0006606 FtsZ-dependent cytokinesis//barrier septum assembly//mitochondrial fusion//regulation of autophagy//cell cycle//DNA replication//regulation of transcription, DNA-templated//protein import into nucleus GO:0003924//GO:0005198//GO:0003700//GO:0043565 GTPase activity//structural molecule activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005741//GO:0005882//GO:0016021//GO:0005737//GO:0005615 transcription factor complex//nucleus//mitochondrial outer membrane//intermediate filament//integral component of membrane//cytoplasm//extracellular space KOG4797 Transcriptional regulator Cluster-8309.5118 BP_3 6.55 0.48 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51180 BP_3 38.00 5.53 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51182 BP_3 67.44 0.90 3907 91084797 XP_972841.1 974 2.9e-102 PREDICTED: zinc transporter ZIP9 [Tribolium castaneum]>gi|270008594|gb|EFA05042.1| hypothetical protein TcasGA2_TC015133 [Tribolium castaneum] -- -- -- -- -- K14715 SLC39A9, ZIP9 solute carrier family 39 (zinc transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14715 Q6NTL1 626 2.7e-63 Zinc transporter ZIP9-A OS=Xenopus laevis GN=slc39a9-a PE=2 SV=1 PF00892//PF01757//PF15048//PF02535 EamA-like transporter family//Acyltransferase family//Organic solute transporter subunit beta protein//ZIP Zinc transporter GO:0055085//GO:0030001//GO:0015721//GO:0006810//GO:0044765 transmembrane transport//metal ion transport//bile acid and bile salt transport//transport//single-organism transport GO:0046982//GO:0005215//GO:0046873//GO:0016747 protein heterodimerization activity//transporter activity//metal ion transmembrane transporter activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005886//GO:0016021//GO:0016020 plasma membrane//integral component of membrane//membrane KOG3907 ZIP-like zinc transporter proteins Cluster-8309.51183 BP_3 25.87 1.75 1006 642914452 XP_008201682.1 831 2.9e-86 PREDICTED: GRAM domain-containing protein 1B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3KR37 180 3.6e-12 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51184 BP_3 1013.37 20.97 2621 91077778 XP_969102.1 2335 3.0e-260 PREDICTED: GRAM domain-containing protein 1B-like isoform X1 [Tribolium castaneum]>gi|642914450|ref|XP_008201680.1| PREDICTED: GRAM domain-containing protein 1B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3KR37 875 2.4e-92 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.51185 BP_3 67.00 0.64 5353 546681938 ERL91934.1 5113 0.0e+00 hypothetical protein D910_09257, partial [Dendroctonus ponderosae] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 O88572 3260 0.0e+00 Low-density lipoprotein receptor-related protein 6 OS=Mus musculus GN=Lrp6 PE=1 SV=1 PF06320//PF02244//PF12859//PF00057 GCN5-like protein 1 (GCN5L1)//Carboxypeptidase activation peptide//Anaphase-promoting complex subunit 1//Low-density lipoprotein receptor domain class A GO:0006508 proteolysis GO:0005515//GO:0004180 protein binding//carboxypeptidase activity GO:0005680//GO:0031083 anaphase-promoting complex//BLOC-1 complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.51189 BP_3 217.77 0.79 13597 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 798 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.4e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF01436//PF01017//PF03124//PF00097//PF00643//PF14634//PF08447//PF06743 NHL repeat//STAT protein, all-alpha domain//EXS family//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger//zinc-RING finger domain//PAS fold//FAST kinase-like protein, subdomain 1 GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0004672//GO:0046872//GO:0003700//GO:0004871//GO:0008270//GO:0005515 protein kinase activity//metal ion binding//transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding//protein binding GO:0005622//GO:0005667//GO:0016021 intracellular//transcription factor complex//integral component of membrane KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.5119 BP_3 108.00 0.84 6459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51191 BP_3 267.79 2.65 5161 546687608 ERL96229.1 1679 6.8e-184 hypothetical protein D910_01506 [Dendroctonus ponderosae]>gi|546687612|gb|ERL96230.1| hypothetical protein D910_01507 [Dendroctonus ponderosae] 817204838 XM_012422887.1 429 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X5, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1538 6.3e-169 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.51195 BP_3 247.00 4.80 2774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168//PF03574 Triple QxxK/R motif-containing protein family//Peptidase family S48 GO:0043158 heterocyst differentiation GO:0004252//GO:0003677 serine-type endopeptidase activity//DNA binding GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.51196 BP_3 72.58 2.70 1586 332374160 AEE62221.1 385 2.3e-34 unknown [Dendroctonus ponderosae]>gi|546682250|gb|ERL92211.1| hypothetical protein D910_09531 [Dendroctonus ponderosae] -- -- -- -- -- K18178 COA5, PET191 cytochrome c oxidase assembly factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18178 A1L3N6 221 1.0e-16 Cytochrome c oxidase assembly factor 5 OS=Xenopus laevis GN=coa5 PE=3 SV=1 PF04706 Dickkopf N-terminal cysteine-rich region GO:0030178//GO:0007275 negative regulation of Wnt signaling pathway//multicellular organismal development -- -- GO:0005576 extracellular region KOG4114 Cytochrome c oxidase assembly protein PET191 Cluster-8309.51197 BP_3 48.52 0.74 3433 642918916 XP_008191654.1 4139 0.0e+00 PREDICTED: apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1 [Tribolium castaneum] 194759777 XM_001962088.1 63 1.48137e-21 Drosophila ananassae GF14596 (Dana\GF14596), mRNA -- -- -- -- O15033 1602 1.6e-176 Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Homo sapiens GN=AREL1 PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.51201 BP_3 29.34 0.31 4916 91092158 XP_967537.1 1017 3.8e-107 PREDICTED: steroid receptor seven-up, isoforms B/C [Tribolium castaneum]>gi|270015100|gb|EFA11548.1| seven up [Tribolium castaneum] 642911915 XM_962444.2 314 6.27851e-161 PREDICTED: Tribolium castaneum seven up (LOC655884), mRNA K08548 NR2F2, TFCOUP2 COUP transcription factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08548 P16375 835 2.0e-87 Steroid receptor seven-up, isoforms B/C OS=Drosophila melanogaster GN=svp PE=2 SV=1 PF00104//PF00105//PF14554 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains)//VEGF heparin-binding domain GO:0030522//GO:0006355//GO:0043401//GO:0007165 intracellular receptor signaling pathway//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//signal transduction GO:0046872//GO:0003700//GO:0008201//GO:0008270//GO:0043565//GO:0004879//GO:0003707 metal ion binding//transcription factor activity, sequence-specific DNA binding//heparin binding//zinc ion binding//sequence-specific DNA binding//RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding//steroid hormone receptor activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3575 FOG: Hormone receptors Cluster-8309.51202 BP_3 745.98 33.19 1375 642913840 XP_008201181.1 425 4.7e-39 PREDICTED: uncharacterized protein LOC103315106 [Tribolium castaneum]>gi|270001659|gb|EEZ98106.1| hypothetical protein TcasGA2_TC000521 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51204 BP_3 3821.44 29.64 6505 270000847 EEZ97294.1 1566 1.1e-170 hypothetical protein TcasGA2_TC011099 [Tribolium castaneum] 642937258 XM_008200538.1 171 2.59019e-81 PREDICTED: Tribolium castaneum mucin-2 (LOC657242), mRNA -- -- -- -- -- -- -- -- PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.51208 BP_3 1762.00 30.96 3035 642920202 XP_008192247.1 1933 1.4e-213 PREDICTED: uncharacterized protein LOC103312691 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06455 NADH dehydrogenase subunit 5 C-terminus GO:0006814//GO:0042773//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ATP synthesis coupled electron transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-8309.51209 BP_3 643.33 9.51 3552 546683281 ERL93113.1 1368 5.4e-148 hypothetical protein D910_10415 [Dendroctonus ponderosae] 755951009 XM_011303317.1 181 3.88846e-87 PREDICTED: Fopius arisanus liprin-alpha-1 (LOC105265686), transcript variant X11, mRNA -- -- -- -- Q13136 1133 4.0e-122 Liprin-alpha-1 OS=Homo sapiens GN=PPFIA1 PE=1 SV=1 PF00884//PF01663//PF02247//PF07647//PF03294//PF00536 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Large coat protein//SAM domain (Sterile alpha motif)//RNA polymerase-associated transcription specificity factor, Rap94//SAM domain (Sterile alpha motif) GO:0008152 metabolic process GO:0003700//GO:0008484//GO:0005198//GO:0005515//GO:0003824 transcription factor activity, sequence-specific DNA binding//sulfuric ester hydrolase activity//structural molecule activity//protein binding//catalytic activity GO:0005667//GO:0019028 transcription factor complex//viral capsid KOG0249 LAR-interacting protein and related proteins Cluster-8309.5121 BP_3 4.08 0.50 685 91081401 XP_972667.1 396 5.4e-36 PREDICTED: exosome complex component RRP43 [Tribolium castaneum]>gi|270006123|gb|EFA02571.1| hypothetical protein TcasGA2_TC008282 [Tribolium castaneum] -- -- -- -- -- K12586 RRP43, EXOSC8, OIP2 exosome complex component RRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12586 Q96B26 309 2.7e-27 Exosome complex component RRP43 OS=Homo sapiens GN=EXOSC8 PE=1 SV=1 PF01084 Ribosomal protein S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.51210 BP_3 178.05 1.73 5244 642912405 XP_008199494.1 3145 0.0e+00 PREDICTED: liprin-alpha-1 isoform X12 [Tribolium castaneum] 642912388 XM_008201264.1 777 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X4, mRNA -- -- -- -- Q13136 1554 8.9e-171 Liprin-alpha-1 OS=Homo sapiens GN=PPFIA1 PE=1 SV=1 PF05513//PF15724 TraA//TMEM119 family GO:0000746//GO:0001503 conjugation//ossification -- -- GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.51211 BP_3 135.38 1.43 4861 642912407 XP_008199495.1 3238 0.0e+00 PREDICTED: liprin-alpha-1 isoform X13 [Tribolium castaneum] 642912406 XM_008201273.1 742 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X13, mRNA -- -- -- -- O75334 1537 7.7e-169 Liprin-alpha-2 OS=Homo sapiens GN=PPFIA2 PE=1 SV=2 PF02459//PF05513 Adenoviral DNA terminal protein//TraA GO:0000746//GO:0006260 conjugation//DNA replication GO:0003677 DNA binding GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.51212 BP_3 68.94 0.64 5452 642912405 XP_008199494.1 3145 0.0e+00 PREDICTED: liprin-alpha-1 isoform X12 [Tribolium castaneum] 642912388 XM_008201264.1 777 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X4, mRNA -- -- -- -- Q13136 1554 9.3e-171 Liprin-alpha-1 OS=Homo sapiens GN=PPFIA1 PE=1 SV=1 PF15724//PF02459 TMEM119 family//Adenoviral DNA terminal protein GO:0001503//GO:0006260 ossification//DNA replication GO:0003677 DNA binding -- -- KOG0249 LAR-interacting protein and related proteins Cluster-8309.51215 BP_3 39.26 0.42 4824 91078392 XP_974372.1 1555 1.5e-169 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270003986|gb|EFA00434.1| hypothetical protein TcasGA2_TC003288 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 594 1.7e-59 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF02086//PF00083//PF07690//PF01770 D12 class N6 adenine-specific DNA methyltransferase//Sugar (and other) transporter//Major Facilitator Superfamily//Reduced folate carrier GO:0032775//GO:0055085//GO:0006810//GO:0006306 DNA methylation on adenine//transmembrane transport//transport//DNA methylation GO:0022857//GO:0009007 transmembrane transporter activity//site-specific DNA-methyltransferase (adenine-specific) activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.51216 BP_3 4.00 1.02 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51218 BP_3 32.57 0.37 4523 270015016 EFA11464.1 753 1.4e-76 hypothetical protein TcasGA2_TC014173 [Tribolium castaneum] -- -- -- -- -- K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q6PFM0 581 5.1e-58 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Danio rerio GN=jmjd6 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain Cluster-8309.5122 BP_3 125.73 8.79 981 546671056 ERL83540.1 991 7.8e-105 hypothetical protein D910_00610 [Dendroctonus ponderosae] -- -- -- -- -- K12586 RRP43, EXOSC8, OIP2 exosome complex component RRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12586 Q96B26 734 2.0e-76 Exosome complex component RRP43 OS=Homo sapiens GN=EXOSC8 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.51220 BP_3 573.90 6.41 4605 642923960 XP_970859.2 718 1.7e-72 PREDICTED: neural Wiskott-Aldrich syndrome protein [Tribolium castaneum]>gi|642923962|ref|XP_008193941.1| PREDICTED: neural Wiskott-Aldrich syndrome protein [Tribolium castaneum]>gi|642923964|ref|XP_008193942.1| PREDICTED: neural Wiskott-Aldrich syndrome protein [Tribolium castaneum] -- -- -- -- -- K05747 WAS Wiskott-Aldrich syndrome protein http://www.genome.jp/dbget-bin/www_bget?ko:K05747 Q91YD9 401 3.9e-37 Neural Wiskott-Aldrich syndrome protein OS=Mus musculus GN=Wasl PE=1 SV=1 PF06105//PF02205 Aph-1 protein//WH2 motif GO:0043085//GO:0016485 positive regulation of catalytic activity//protein processing GO:0003779 actin binding GO:0016021 integral component of membrane KOG3671 Actin regulatory protein (Wiskott-Aldrich syndrome protein) Cluster-8309.51222 BP_3 72.56 1.28 3014 190702371 ACE75264.1 1760 1.6e-193 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51223 BP_3 17.84 0.50 1999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14980 TIP39 peptide GO:0007218 neuropeptide signaling pathway -- -- GO:0005576 extracellular region -- -- Cluster-8309.51225 BP_3 5.89 0.52 838 766935896 XP_011500333.1 177 1.6e-10 PREDICTED: THAP domain-containing protein 1 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.51227 BP_3 697.39 2.86 12053 270016002 EFA12450.1 1111 1.2e-117 hypothetical protein TcasGA2_TC016185 [Tribolium castaneum]>gi|270016905|gb|EFA13351.1| hypothetical protein TcasGA2_TC006959 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 315 9.6e-27 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF13683//PF08398//PF00770//PF01637//PF02902//PF00665//PF02022 Integrase core domain//Parvovirus coat protein VP1//Adenovirus endoprotease//Archaeal ATPase//Ulp1 protease family, C-terminal catalytic domain//Integrase core domain//Integrase Zinc binding domain GO:0006508//GO:0015074 proteolysis//DNA integration GO:0008270//GO:0008234//GO:0004197//GO:0005524//GO:0005198 zinc ion binding//cysteine-type peptidase activity//cysteine-type endopeptidase activity//ATP binding//structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.51229 BP_3 4.00 0.39 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51230 BP_3 14.00 0.46 1748 -- -- -- -- -- 642923663 XM_008195611.1 51 3.50126e-15 PREDICTED: Tribolium castaneum acetylcholinesterase 1 (LOC662258), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51232 BP_3 22.41 1.87 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51235 BP_3 222.30 2.12 5352 478258110 ENN78248.1 2446 8.2e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 4.32527e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 3.1e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF01435//PF00400//PF08063//PF09127//PF01433 Peptidase family M48//WD domain, G-beta repeat//PADR1 (NUC008) domain//Leukotriene A4 hydrolase, C-terminal//Peptidase family M1 GO:0006508//GO:0019370 proteolysis//leukotriene biosynthetic process GO:0004222//GO:0005515//GO:0008237//GO:0008270//GO:0003950 metalloendopeptidase activity//protein binding//metallopeptidase activity//zinc ion binding//NAD+ ADP-ribosyltransferase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.5124 BP_3 6.18 0.40 1036 91081401 XP_972667.1 670 1.4e-67 PREDICTED: exosome complex component RRP43 [Tribolium castaneum]>gi|270006123|gb|EFA02571.1| hypothetical protein TcasGA2_TC008282 [Tribolium castaneum] -- -- -- -- -- K12586 RRP43, EXOSC8, OIP2 exosome complex component RRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12586 Q96B26 523 6.2e-52 Exosome complex component RRP43 OS=Homo sapiens GN=EXOSC8 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.51242 BP_3 109.04 1.14 4917 478252787 ENN73180.1 1289 1.1e-138 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 5.6e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4780 Uncharacterized conserved protein Cluster-8309.51243 BP_3 45.26 1.34 1921 189240093 XP_972388.2 430 1.7e-39 PREDICTED: myosin heavy chain, clone 203 isoform X1 [Tribolium castaneum]>gi|270012237|gb|EFA08685.1| hypothetical protein TcasGA2_TC006355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.51244 BP_3 4.00 9.35 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51246 BP_3 2.00 0.33 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51247 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51249 BP_3 33.10 0.35 4901 642925690 XP_008194671.1 3246 0.0e+00 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2318 2.1e-259 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.51250 BP_3 122.86 1.25 5047 642925690 XP_008194671.1 3246 0.0e+00 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2318 2.2e-259 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.51251 BP_3 580.59 3.82 7620 780669493 XP_011694869.1 1341 1.6e-144 PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata]>gi|780669497|ref|XP_011694870.1| PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata]>gi|780669501|ref|XP_011694871.1| PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata] 642922119 XM_008194802.1 71 1.18058e-25 PREDICTED: Tribolium castaneum uncharacterized LOC103312925 (LOC103312925), mRNA -- -- -- -- M9NEY8 1073 7.7e-115 DNA N6-methyl adenine demethylase OS=Drosophila melanogaster GN=Tet PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51254 BP_3 75.83 0.80 4882 642931654 XP_008196673.1 2383 1.5e-265 PREDICTED: rap1 GTPase-activating protein 1 isoform X1 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.59934e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 4.3e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF07836//PF02145//PF02188//PF13851 DmpG-like communication domain//Rap/ran-GAP//GoLoco motif//Growth-arrest specific micro-tubule binding GO:0048870//GO:0019439//GO:0051056 cell motility//aromatic compound catabolic process//regulation of small GTPase mediated signal transduction GO:0016833//GO:0030695//GO:0005096 oxo-acid-lyase activity//GTPase regulator activity//GTPase activator activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.51256 BP_3 450.97 2.19 10214 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.6e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF00632//PF01155//PF02891//PF00168//PF00397//PF05430 HECT-domain (ubiquitin-transferase)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//MIZ/SP-RING zinc finger//C2 domain//WW domain//S-adenosyl-L-methionine-dependent methyltransferase GO:0055114//GO:0006464//GO:0016567 oxidation-reduction process//cellular protein modification process//protein ubiquitination GO:0008270//GO:0016645//GO:0016151//GO:0004842//GO:0005515 zinc ion binding//oxidoreductase activity, acting on the CH-NH group of donors//nickel cation binding//ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.51258 BP_3 8.03 2.13 473 478256438 ENN76625.1 195 7.5e-13 hypothetical protein YQE_06882, partial [Dendroctonus ponderosae]>gi|546677604|gb|ERL88409.1| hypothetical protein D910_05795 [Dendroctonus ponderosae] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51263 BP_3 581.30 14.29 2253 255958232 NP_001157646.1 2114 1.1e-234 matrix metalloproteinase 1 isoform 1 precursor [Tribolium castaneum]>gi|270008219|gb|EFA04667.1| matrix metalloproteinase 1 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q10739 816 1.4e-85 Matrix metalloproteinase-14 OS=Rattus norvegicus GN=Mmp14 PE=2 SV=2 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0004222//GO:0005509//GO:0008270 metalloendopeptidase activity//calcium ion binding//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.51264 BP_3 1920.36 53.93 2008 91090500 XP_969356.1 1185 5.1e-127 PREDICTED: shootin-1 [Tribolium castaneum]>gi|642935361|ref|XP_008197981.1| PREDICTED: shootin-1 [Tribolium castaneum]>gi|270013357|gb|EFA09805.1| hypothetical protein TcasGA2_TC011950 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0MZ66 206 7.0e-15 Shootin-1 OS=Homo sapiens GN=KIAA1598 PE=1 SV=4 PF17078//PF00435//PF05531//PF04728 SWI5-dependent HO expression protein 3//Spectrin repeat//Nucleopolyhedrovirus P10 protein//Lipoprotein leucine-zipper GO:0051028//GO:0048309 mRNA transport//endoplasmic reticulum inheritance GO:0005515 protein binding GO:0019028//GO:0019867 viral capsid//outer membrane -- -- Cluster-8309.51265 BP_3 49.79 0.46 5511 642920075 XP_008192196.1 1113 3.1e-118 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 703 4.5e-72 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03453 MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.51266 BP_3 99.23 2.49 2209 642920075 XP_008192196.1 1067 2.7e-113 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 Q9NQX3 865 2.9e-91 Gephyrin OS=Homo sapiens GN=GPHN PE=1 SV=1 PF03454//PF03453 MoeA C-terminal region (domain IV)//MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.51274 BP_3 146.00 3.43 2346 478251119 ENN71595.1 1727 8.4e-190 hypothetical protein YQE_11694, partial [Dendroctonus ponderosae] -- -- -- -- -- K10727 CDT1 chromatin licensing and DNA replication factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10727 Q9I9A7 731 1.1e-75 DNA replication factor Cdt1 OS=Xenopus laevis GN=cdt1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4762 DNA replication factor Cluster-8309.51277 BP_3 10.00 0.97 790 546682659 ERL92571.1 354 4.6e-31 hypothetical protein D910_09884, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02724//PF06459//PF06783 CDC45-like protein//Ryanodine Receptor TM 4-6//Uncharacterised protein family (UPF0239) GO:0006270//GO:0006874//GO:0006816 DNA replication initiation//cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.51278 BP_3 14.79 0.31 2574 642920590 XP_008192477.1 730 3.8e-74 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 588 4.5e-59 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.51279 BP_3 86.82 1.15 3939 332375210 AEE62746.1 1041 5.0e-110 unknown [Dendroctonus ponderosae]>gi|478254335|gb|ENN74587.1| hypothetical protein YQE_08710, partial [Dendroctonus ponderosae]>gi|546674053|gb|ERL85541.1| hypothetical protein D910_02960 [Dendroctonus ponderosae] -- -- -- -- -- K02895 RP-L24, MRPL24, rplX large subunit ribosomal protein L24 http://www.genome.jp/dbget-bin/www_bget?ko:K02895 Q29MA5 828 1.0e-86 Probable 39S ribosomal protein L24, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL24 PE=3 SV=1 PF13482 RNase_H superfamily -- -- GO:0003676 nucleic acid binding -- -- KOG3801 Uncharacterized conserved protein BCN92 Cluster-8309.51283 BP_3 43.47 2.65 1082 91092264 XP_967363.1 701 3.6e-71 PREDICTED: peptide deformylase, mitochondrial [Tribolium castaneum]>gi|270001218|gb|EEZ97665.1| hypothetical protein TcasGA2_TC016210 [Tribolium castaneum] -- -- -- -- -- K01462 PDF, def peptide deformylase http://www.genome.jp/dbget-bin/www_bget?ko:K01462 Q9HBH1 388 2.9e-36 Peptide deformylase, mitochondrial OS=Homo sapiens GN=PDF PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3137 Peptide deformylase Cluster-8309.51285 BP_3 192.73 2.43 4120 642926608 XP_969412.2 812 1.9e-83 PREDICTED: histone-lysine N-methyltransferase pr-set7 [Tribolium castaneum] -- -- -- -- -- K11428 SETD8 histone-lysine N-methyltransferase SETD8 http://www.genome.jp/dbget-bin/www_bget?ko:K11428 Q9VFK6 626 2.8e-63 Histone-lysine N-methyltransferase pr-set7 OS=Drosophila melanogaster GN=pr-set7 PE=1 SV=2 PF07571//PF00856 TAF6 C-terminal HEAT repeat domain//SET domain GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0005515 protein binding GO:0005634 nucleus KOG1085 Predicted methyltransferase (contains a SET domain) Cluster-8309.51286 BP_3 15.39 0.45 1947 642931033 XP_008196186.1 211 4.3e-14 PREDICTED: uncharacterized protein LOC103313792 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05497 Destabilase GO:0005975 carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-8309.51287 BP_3 31.00 1.09 1664 675880570 XP_009025787.1 646 1.3e-64 hypothetical protein HELRODRAFT_163757 [Helobdella robusta]>gi|555693431|gb|ESN96663.1| hypothetical protein HELRODRAFT_163757 [Helobdella robusta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5129 BP_3 12.39 0.35 2003 642922857 XP_008200425.1 394 2.7e-35 PREDICTED: FK506-binding protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PU47 157 3.3e-09 PDZ and LIM domain protein 3 OS=Gallus gallus GN=PDLIM3 PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51290 BP_3 1.00 0.40 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51294 BP_3 335.71 4.02 4319 642912272 XP_008200632.1 793 3.1e-81 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 1.1e-20 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF01414//PF04625 Trypsin//Delta serrate ligand//DEC-1 protein, N-terminal region GO:0007154//GO:0007304//GO:0006508 cell communication//chorion-containing eggshell formation//proteolysis GO:0004252//GO:0005213 serine-type endopeptidase activity//structural constituent of chorion GO:0042600//GO:0016020//GO:0005576 chorion//membrane//extracellular region -- -- Cluster-8309.51295 BP_3 29.58 1.72 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51296 BP_3 140.91 9.35 1018 189238253 XP_001813297.1 1260 5.2e-136 PREDICTED: GPN-loop GTPase 3 [Tribolium castaneum]>gi|270008652|gb|EFA05100.1| hypothetical protein TcasGA2_TC015199 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9D3W4 830 1.6e-87 GPN-loop GTPase 3 OS=Mus musculus GN=Gpn3 PE=2 SV=1 PF00004//PF00910//PF00005//PF01926 ATPase family associated with various cellular activities (AAA)//RNA helicase//ABC transporter//50S ribosome-binding GTPase -- -- GO:0003724//GO:0005524//GO:0000166//GO:0005525//GO:0003723//GO:0016887 RNA helicase activity//ATP binding//nucleotide binding//GTP binding//RNA binding//ATPase activity -- -- KOG1534 Putative transcription factor FET5 Cluster-8309.51299 BP_3 36.54 7.71 520 642926212 XP_008194831.1 306 1.1e-25 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926214|ref|XP_008194832.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926216|ref|XP_973431.2| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926218|ref|XP_008194833.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926220|ref|XP_008194834.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926222|ref|XP_008194835.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] 749752848 XM_011140486.1 61 2.74328e-21 PREDICTED: Harpegnathos saltator putative fatty acyl-CoA reductase CG5065 (LOC105182795), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 209 8.0e-16 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01715//PF01118//PF01073//PF01370 IPP transferase//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0006694//GO:0055114//GO:0008209//GO:0008033//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//tRNA processing//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0051287//GO:0016616//GO:0003854//GO:0050662//GO:0003824 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.5130 BP_3 36.01 1.14 1815 642922857 XP_008200425.1 394 2.4e-35 PREDICTED: FK506-binding protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PU47 157 3.0e-09 PDZ and LIM domain protein 3 OS=Gallus gallus GN=PDLIM3 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51301 BP_3 15.93 0.31 2737 546675694 ERL86836.1 661 4.0e-66 hypothetical protein D910_04239 [Dendroctonus ponderosae] -- -- -- -- -- K15865 CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15865 Q291H5 555 3.2e-55 Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Drosophila pseudoobscura pseudoobscura GN=GA19679 PE=3 SV=1 PF05818//PF00919 Enterobacterial TraT complement resistance protein//Uncharacterized protein family UPF0004 GO:0046999//GO:0009451 regulation of conjugation//RNA modification GO:0051539//GO:0003824 4 iron, 4 sulfur cluster binding//catalytic activity GO:0019867 outer membrane KOG4355 Predicted Fe-S oxidoreductase Cluster-8309.51302 BP_3 146.09 3.13 2543 260810939 XP_002600180.1 645 2.7e-64 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NN14 482 8.7e-47 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF07776//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.51305 BP_3 151.00 4.81 1805 546678228 ERL88904.1 1130 1.1e-120 hypothetical protein D910_06285, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5VT52 251 3.8e-20 Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens GN=RPRD2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2669 Regulator of nuclear mRNA Cluster-8309.51309 BP_3 63.00 4.34 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00964 Elicitin GO:0006952//GO:0009405 defense response//pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.5131 BP_3 58.07 1.75 1887 642922857 XP_008200425.1 689 1.6e-69 PREDICTED: FK506-binding protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PU47 157 3.1e-09 PDZ and LIM domain protein 3 OS=Gallus gallus GN=PDLIM3 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51311 BP_3 13.79 2.85 525 478257445 ENN77601.1 432 2.8e-40 hypothetical protein YQE_05896, partial [Dendroctonus ponderosae] 159484014 XM_001700004.1 35 7.87111e-07 Chlamydomonas reinhardtii strain CC-503 cw92 mt+ K18164 NDUFAF7 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18164 Q2KHV5 305 6.0e-27 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 OS=Bos taurus GN=NDUFAF7 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2901 Uncharacterized conserved protein Cluster-8309.51312 BP_3 43.34 0.57 3965 546673906 ERL85422.1 313 1.3e-25 hypothetical protein D910_02842 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51313 BP_3 325.70 1.87 8702 642937185 XP_008198729.1 2663 9.1e-298 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 4.68338e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2237 9.4e-250 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF00023//PF00995//PF00856//PF05192//PF13606//PF02068//PF05033//PF11744 Ankyrin repeat//Sec1 family//SET domain//MutS domain III//Ankyrin repeat//Plant PEC family metallothionein//Pre-SET motif//Aluminium activated malate transporter GO:0006904//GO:0015743//GO:0016192//GO:0034968//GO:0006298//GO:0006554//GO:0006479 vesicle docking involved in exocytosis//malate transport//vesicle-mediated transport//histone lysine methylation//mismatch repair//lysine catabolic process//protein methylation GO:0005515//GO:0005524//GO:0018024//GO:0008270//GO:0030983 protein binding//ATP binding//histone-lysine N-methyltransferase activity//zinc ion binding//mismatched DNA binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.51315 BP_3 242.98 2.31 5368 642940052 XP_008200969.1 2894 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 1.8e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF00910//PF04851//PF00005//PF07724//PF00439//PF00004//PF06068//PF05496//PF07728//PF01695 RNA helicase//Type III restriction enzyme, res subunit//ABC transporter//AAA domain (Cdc48 subfamily)//Bromodomain//ATPase family associated with various cellular activities (AAA)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0003724//GO:0009378//GO:0016887//GO:0005515//GO:0003723//GO:0003678//GO:0005524//GO:0016787//GO:0003677 RNA helicase activity//four-way junction helicase activity//ATPase activity//protein binding//RNA binding//DNA helicase activity//ATP binding//hydrolase activity//DNA binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.51316 BP_3 20.24 1.05 1222 270014679 EFA11127.1 303 5.8e-25 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K12041 SLC9A6_7, NHE6_7 solute carrier family 9 (sodium/hydrogen exchanger), member 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K12041 Q92581 156 2.7e-09 Sodium/hydrogen exchanger 6 OS=Homo sapiens GN=SLC9A6 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51317 BP_3 247.00 13.79 1155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16517 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.51318 BP_3 363.38 3.19 5790 91083069 XP_967587.1 4327 0.0e+00 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDW6 2521 7.3e-283 Dystrophin, isoforms A/C/F/G/H OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF01166//PF14641//PF08115//PF00569//PF16473//PF00435//PF00397//PF07649 TSC-22/dip/bun family//Helix-turn-helix DNA-binding domain of SPT6//SFI toxin family//Zinc finger, ZZ type//Domain of unknown function (DUF5051)//Spectrin repeat//WW domain//C1-like domain GO:0009405//GO:0055114//GO:0006355 pathogenesis//oxidation-reduction process//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0003700//GO:0047134//GO:0008270//GO:0005509//GO:0003676 protein binding//DNA binding//transcription factor activity, sequence-specific DNA binding//protein-disulfide reductase activity//zinc ion binding//calcium ion binding//nucleic acid binding GO:0005667//GO:0005576 transcription factor complex//extracellular region -- -- Cluster-8309.51319 BP_3 4.00 0.43 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51321 BP_3 1167.92 9.83 6021 91083069 XP_967587.1 4327 0.0e+00 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDW6 2521 7.6e-283 Dystrophin, isoforms A/C/F/G/H OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF14641//PF00569//PF08115//PF07649//PF00397//PF16473//PF00435//PF01166 Helix-turn-helix DNA-binding domain of SPT6//Zinc finger, ZZ type//SFI toxin family//C1-like domain//WW domain//Domain of unknown function (DUF5051)//Spectrin repeat//TSC-22/dip/bun family GO:0009405//GO:0006355//GO:0055114 pathogenesis//regulation of transcription, DNA-templated//oxidation-reduction process GO:0003677//GO:0005515//GO:0008270//GO:0005509//GO:0003676//GO:0003700//GO:0047134 DNA binding//protein binding//zinc ion binding//calcium ion binding//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//protein-disulfide reductase activity GO:0005667//GO:0005576 transcription factor complex//extracellular region -- -- Cluster-8309.51322 BP_3 190.91 1.52 6329 91083069 XP_967587.1 3512 0.0e+00 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDW3 2107 8.1e-235 Dystrophin, isoform B OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF11365//PF11802//PF08826//PF10473//PF09177//PF08115//PF00170//PF14641//PF00397//PF16473//PF04111//PF02601//PF02183//PF00569//PF04977//PF04632 Protein of unknown function (DUF3166)//Centromere-associated protein K//DMPK coiled coil domain like//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//SFI toxin family//bZIP transcription factor//Helix-turn-helix DNA-binding domain of SPT6//WW domain//Domain of unknown function (DUF5051)//Autophagy protein Apg6//Exonuclease VII, large subunit//Homeobox associated leucine zipper//Zinc finger, ZZ type//Septum formation initiator//Fusaric acid resistance protein family GO:0007049//GO:0006355//GO:0006810//GO:0006914//GO:0009069//GO:0006468//GO:0009405//GO:0006308//GO:0010506//GO:0048193//GO:0016310 cell cycle//regulation of transcription, DNA-templated//transport//autophagy//serine family amino acid metabolic process//protein phosphorylation//pathogenesis//DNA catabolic process//regulation of autophagy//Golgi vesicle transport//phosphorylation GO:0008270//GO:0043565//GO:0042803//GO:0005515//GO:0008855//GO:0003677//GO:0004674//GO:0003700//GO:0045502//GO:0008134//GO:0005524//GO:0003676//GO:0005509 zinc ion binding//sequence-specific DNA binding//protein homodimerization activity//protein binding//exodeoxyribonuclease VII activity//DNA binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//dynein binding//transcription factor binding//ATP binding//nucleic acid binding//calcium ion binding GO:0016020//GO:0005576//GO:0005886//GO:0005634//GO:0005615//GO:0009318//GO:0005667//GO:0030286 membrane//extracellular region//plasma membrane//nucleus//extracellular space//exodeoxyribonuclease VII complex//transcription factor complex//dynein complex -- -- Cluster-8309.51326 BP_3 46.68 0.53 4533 642916479 XP_008191061.1 1715 4.0e-188 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TUF1 1179 2.3e-127 Serrate RNA effector molecule homolog OS=Anopheles gambiae GN=Ars2 PE=3 SV=3 PF09726//PF00076 Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding GO:0016021 integral component of membrane KOG2295 C2H2 Zn-finger protein Cluster-8309.51328 BP_3 1347.56 26.03 2787 642916479 XP_008191061.1 1715 2.5e-188 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TUF1 1179 1.4e-127 Serrate RNA effector molecule homolog OS=Anopheles gambiae GN=Ars2 PE=3 SV=3 PF05793//PF09726//PF00076 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006367//GO:0032968 transcription initiation from RNA polymerase II promoter//positive regulation of transcription elongation from RNA polymerase II promoter GO:0000166//GO:0003677//GO:0003676 nucleotide binding//DNA binding//nucleic acid binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG2295 C2H2 Zn-finger protein Cluster-8309.51331 BP_3 1.00 4.17 269 332019131 EGI59647.1 249 2.3e-19 FLJ37770-like protein, partial [Acromyrmex echinatior] 746870179 XM_011067966.1 123 4.56113e-56 PREDICTED: Acromyrmex echinatior putative uncharacterized protein FLJ37770 (LOC105153239), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51334 BP_3 11503.00 587.79 1235 553041307 AGY54953.1 168 2.7e-09 encapsulation-relating protein [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51335 BP_3 353.50 13.15 1587 -- -- -- -- -- 642913213 XM_008203219.1 81 6.67499e-32 PREDICTED: Tribolium castaneum zinc finger MIZ domain-containing protein 1 (LOC664124), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF06862//PF00656 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity GO:0005634 nucleus -- -- Cluster-8309.51336 BP_3 19.96 0.56 2008 308495432 XP_003109904.1 234 9.6e-17 hypothetical protein CRE_06611 [Caenorhabditis remanei]>gi|308244741|gb|EFO88693.1| hypothetical protein CRE_06611 [Caenorhabditis remanei] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51338 BP_3 40.06 0.62 3407 642936222 XP_008198354.1 1073 8.4e-114 PREDICTED: glutamyl aminopeptidase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32LQ0 675 4.9e-69 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.51340 BP_3 75.00 2.08 2033 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51342 BP_3 437.30 9.36 2543 91090232 XP_968695.1 3206 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 51 homolog [Tribolium castaneum]>gi|270013774|gb|EFA10222.1| hypothetical protein TcasGA2_TC012418 [Tribolium castaneum] 462282022 APGK01057453.1 216 9.70063e-107 Dendroctonus ponderosae Seq01057463, whole genome shotgun sequence -- -- -- -- Q8MSY4 1960 3.6e-218 Vacuolar protein sorting-associated protein 51 homolog OS=Drosophila melanogaster GN=CG15087 PE=2 SV=1 PF06009//PF04048//PF04124//PF04513 Laminin Domain II//Sec8 exocyst complex component specific domain//Dor1-like family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0006904//GO:0007155//GO:0015031 vesicle docking involved in exocytosis//cell adhesion//protein transport GO:0005198 structural molecule activity GO:0019028//GO:0019031//GO:0017119//GO:0000145 viral capsid//viral envelope//Golgi transport complex//exocyst KOG2346 Uncharacterized conserved protein Cluster-8309.51343 BP_3 1418.87 12.91 5589 478254436 ENN74688.1 2918 0.0e+00 hypothetical protein YQE_08805, partial [Dendroctonus ponderosae] 697484427 XM_009675369.1 47 1.89866e-12 PREDICTED: Struthio camelus australis methionyl-tRNA synthetase (MARS), partial mRNA K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q6PF21 2080 9.7e-232 Methionine--tRNA ligase, cytoplasmic OS=Xenopus laevis GN=mars PE=2 SV=1 PF00133//PF09334//PF08264//PF00458 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Anticodon-binding domain of tRNA//WHEP-TRS domain GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG1247 Methionyl-tRNA synthetase Cluster-8309.51346 BP_3 276.08 2.21 6323 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.51348 BP_3 335.53 4.88 3608 91077430 XP_966364.1 2481 4.8e-277 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [Tribolium castaneum]>gi|270001627|gb|EEZ98074.1| hypothetical protein TcasGA2_TC000481 [Tribolium castaneum] 752892703 XM_011266149.1 450 0 PREDICTED: Camponotus floridanus putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 (LOC105256330), mRNA K12820 DHX15, PRP43 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12820 O35286 2035 1.0e-226 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Mus musculus GN=Dhx15 PE=1 SV=2 PF07652//PF00270//PF00005//PF04851//PF09339//PF00437//PF00448//PF01695//PF00063//PF04408 Flavivirus DEAD domain//DEAD/DEAH box helicase//ABC transporter//Type III restriction enzyme, res subunit//IclR helix-turn-helix domain//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//IstB-like ATP binding protein//Myosin head (motor domain)//Helicase associated domain (HA2) GO:0006614//GO:0019079//GO:0006810//GO:0006355 SRP-dependent cotranslational protein targeting to membrane//viral genome replication//transport//regulation of transcription, DNA-templated GO:0004386//GO:0005524//GO:0016787//GO:0003677//GO:0008026//GO:0005525//GO:0003774//GO:0016887//GO:0003676 helicase activity//ATP binding//hydrolase activity//DNA binding//ATP-dependent helicase activity//GTP binding//motor activity//ATPase activity//nucleic acid binding GO:0016459 myosin complex KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.51349 BP_3 656.36 13.87 2572 91077430 XP_966364.1 3508 0.0e+00 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [Tribolium castaneum]>gi|270001627|gb|EEZ98074.1| hypothetical protein TcasGA2_TC000481 [Tribolium castaneum] 665808807 XM_008554521.1 649 0 PREDICTED: Microplitis demolitor putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 (LOC103574950), transcript variant X2, mRNA K12820 DHX15, PRP43 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12820 O43143 2950 0.0e+00 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens GN=DHX15 PE=1 SV=2 PF07652//PF00270//PF04851//PF09339//PF00005//PF00448//PF00437//PF00063//PF04408//PF01695 Flavivirus DEAD domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//IclR helix-turn-helix domain//ABC transporter//SRP54-type protein, GTPase domain//Type II/IV secretion system protein//Myosin head (motor domain)//Helicase associated domain (HA2)//IstB-like ATP binding protein GO:0006355//GO:0006810//GO:0006614//GO:0019079 regulation of transcription, DNA-templated//transport//SRP-dependent cotranslational protein targeting to membrane//viral genome replication GO:0003676//GO:0016887//GO:0003774//GO:0005525//GO:0008026//GO:0003677//GO:0016787//GO:0005524//GO:0004386 nucleic acid binding//ATPase activity//motor activity//GTP binding//ATP-dependent helicase activity//DNA binding//hydrolase activity//ATP binding//helicase activity GO:0016459 myosin complex KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.5135 BP_3 2.00 0.42 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51350 BP_3 590.20 4.02 7362 642924922 XP_008194098.1 1584 1.0e-172 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMF0 206 2.6e-14 Cordon-bleu protein-like 1 OS=Mus musculus GN=Cobll1 PE=1 SV=2 PF02196//PF01349//PF02205 Raf-like Ras-binding domain//Flavivirus non-structural protein NS4B//WH2 motif GO:0007165//GO:0006144//GO:0006370//GO:0009451//GO:0006396 signal transduction//purine nucleobase metabolic process//7-methylguanosine mRNA capping//RNA modification//RNA processing GO:0005057//GO:0004482//GO:0003779//GO:0003968//GO:0070008//GO:0004252//GO:0016817//GO:0017111//GO:0004483 receptor signaling protein activity//mRNA (guanine-N7-)-methyltransferase activity//actin binding//RNA-directed RNA polymerase activity//serine-type exopeptidase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//nucleoside-triphosphatase activity//mRNA (nucleoside-2'-O-)-methyltransferase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.51353 BP_3 12.73 1.99 600 642926574 XP_008194926.1 315 1.2e-26 PREDICTED: scavenger receptor class B member 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10766 Multidrug efflux pump-associated protein AcrZ GO:0015893//GO:0006855 drug transport//drug transmembrane transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.51354 BP_3 21.00 1.40 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51355 BP_3 154.18 4.07 2119 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04441 Poxvirus early transcription factor (VETF), large subunit GO:0045893 positive regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.51358 BP_3 167.00 1.17 7197 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51359 BP_3 489.08 5.21 4813 478251301 ENN71769.1 1449 3.0e-157 hypothetical protein YQE_11504, partial [Dendroctonus ponderosae] 820835140 XM_012484551.1 290 1.34933e-147 PREDICTED: Apis florea putative GPI-anchor transamidase (LOC105735008), mRNA K05290 PIGK phosphatidylinositol glycan, class K http://www.genome.jp/dbget-bin/www_bget?ko:K05290 Q8T4E1 1232 1.8e-133 Putative GPI-anchor transamidase OS=Drosophila melanogaster GN=CG4406 PE=2 SV=1 PF01650//PF01979 Peptidase C13 family//Amidohydrolase family GO:0006508 proteolysis GO:0016787//GO:0008233 hydrolase activity//peptidase activity -- -- KOG1349 Gpi-anchor transamidase Cluster-8309.51360 BP_3 6.00 0.54 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51361 BP_3 128.55 4.11 1800 91084337 XP_972793.1 775 1.6e-79 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 3.33745e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 515 9.2e-51 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.51362 BP_3 187.78 13.38 968 817218269 XP_012284990.1 863 5.3e-90 PREDICTED: ATP-dependent Clp protease proteolytic subunit, mitochondrial [Orussus abietinus] -- -- -- -- -- K01358 clpP, CLPP ATP-dependent Clp protease, protease subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01358 Q16740 781 7.1e-82 ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens GN=CLPP PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0840 ATP-dependent Clp protease, proteolytic subunit Cluster-8309.51363 BP_3 408.84 3.74 5563 91093076 XP_968784.1 1144 8.0e-122 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1007 2.5e-107 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51366 BP_3 1.48 0.41 467 91093076 XP_968784.1 693 1.3e-70 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 584 2.4e-59 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51367 BP_3 62.79 0.83 3922 642922996 XP_008200488.1 1531 7.5e-167 PREDICTED: GATA-binding factor A isoform X2 [Tribolium castaneum] 687916009 LK995611.1 47 1.32868e-12 Rhabditophanes sp. KR3021 genome assembly Rhabditophanes_sp_KR3021 ,scaffold RSKR_scaffold0000049 K09183 GATA4 GATA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09183 P52168 796 5.2e-83 GATA-binding factor A OS=Drosophila melanogaster GN=pnr PE=1 SV=1 PF01873//PF08273//PF00320 Domain found in IF2B/IF5//Zinc-binding domain of primase-helicase//GATA zinc finger GO:0006355//GO:0006413//GO:0006269//GO:0006351//GO:0006446 regulation of transcription, DNA-templated//translational initiation//DNA replication, synthesis of RNA primer//transcription, DNA-templated//regulation of translational initiation GO:0043565//GO:0008270//GO:0003700//GO:0004386//GO:0003896//GO:0003743 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//helicase activity//DNA primase activity//translation initiation factor activity GO:0005840//GO:0005730//GO:0005657//GO:0005667 ribosome//nucleolus//replication fork//transcription factor complex KOG1601 GATA-4/5/6 transcription factors Cluster-8309.51368 BP_3 153.59 1.86 4276 642914414 XP_008201486.1 3260 0.0e+00 PREDICTED: protein groucho-1-like isoform X2 [Tribolium castaneum] 642914413 XM_008203264.1 710 0 PREDICTED: Tribolium castaneum protein groucho-1-like (LOC655664), transcript variant X2, mRNA -- -- -- -- Q62441 2314 5.4e-259 Transducin-like enhancer protein 4 OS=Mus musculus GN=Tle4 PE=1 SV=4 PF03920//PF02183//PF00400 Groucho/TLE N-terminal Q-rich domain//Homeobox associated leucine zipper//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.51369 BP_3 823.03 8.37 5034 642914414 XP_008201486.1 3275 0.0e+00 PREDICTED: protein groucho-1-like isoform X2 [Tribolium castaneum] 642914413 XM_008203264.1 911 0 PREDICTED: Tribolium castaneum protein groucho-1-like (LOC655664), transcript variant X2, mRNA -- -- -- -- Q62441 2324 4.4e-260 Transducin-like enhancer protein 4 OS=Mus musculus GN=Tle4 PE=1 SV=4 PF00400//PF10538//PF03920//PF02183 WD domain, G-beta repeat//Immunoreceptor tyrosine-based activation motif//Groucho/TLE N-terminal Q-rich domain//Homeobox associated leucine zipper GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.5137 BP_3 3.00 0.81 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51375 BP_3 106.34 2.63 2238 380017601 XP_003692741.1 1817 2.9e-200 PREDICTED: 5'-nucleotidase domain-containing protein 3 isoform X2 [Apis florea] -- -- -- -- -- -- -- -- -- Q6GN91 1104 5.8e-119 5'-nucleotidase domain-containing protein 3 OS=Xenopus laevis GN=nt5dc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.51376 BP_3 73.68 1.49 2672 808131500 XP_012168405.1 1394 3.9e-151 PREDICTED: 5'-nucleotidase domain-containing protein 3 isoform X1 [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q6GN91 848 3.3e-89 5'-nucleotidase domain-containing protein 3 OS=Xenopus laevis GN=nt5dc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.51377 BP_3 12.03 1.70 633 478262482 ENN81153.1 304 2.3e-25 hypothetical protein YQE_02519, partial [Dendroctonus ponderosae]>gi|546672793|gb|ERL84549.1| hypothetical protein D910_01979 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51379 BP_3 4.66 0.36 909 546680296 ERL90594.1 502 3.6e-48 hypothetical protein D910_07941 [Dendroctonus ponderosae] -- -- -- -- -- K04559 HIP1 huntingtin interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04559 O00291 311 2.1e-27 Huntingtin-interacting protein 1 OS=Homo sapiens GN=HIP1 PE=1 SV=5 PF01608 I/LWEQ domain -- -- GO:0003779 actin binding -- -- KOG0980 Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 Cluster-8309.51380 BP_3 15.00 2.76 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51381 BP_3 94.00 1.91 2662 270016078 EFA12526.1 192 9.4e-12 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02160 Cauliflower mosaic virus peptidase (A3) GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.51383 BP_3 5.00 0.39 909 270009884 EFA06332.1 307 1.5e-25 hypothetical protein TcasGA2_TC009203 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641E3 250 2.5e-20 Acyl-CoA-binding domain-containing protein 5 OS=Xenopus laevis GN=acbd5 PE=2 SV=1 PF02315//PF00887 Methanol dehydrogenase beta subunit//Acyl CoA binding protein GO:0015946//GO:0055114 methanol oxidation//oxidation-reduction process GO:0004022//GO:0000062 alcohol dehydrogenase (NAD) activity//fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-8309.51384 BP_3 16.00 10.17 364 478251443 ENN71908.1 168 7.7e-10 hypothetical protein YQE_11445, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T079 139 7.3e-08 Putative oxidoreductase GLYR1 homolog OS=Drosophila melanogaster GN=CG4747 PE=1 SV=1 PF04926//PF14833 Poly(A) polymerase predicted RNA binding domain//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase GO:0043631 RNA polyadenylation GO:0003723//GO:0051287 RNA binding//NAD binding -- -- -- -- Cluster-8309.51385 BP_3 12.66 0.86 1002 642935650 XP_008198099.1 1107 2.8e-118 PREDICTED: post-GPI attachment to proteins factor 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K0P4 736 1.2e-76 Post-GPI attachment to proteins factor 3 OS=Drosophila melanogaster GN=PGAP3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2970 Predicted membrane protein Cluster-8309.51386 BP_3 34.80 1.31 1568 91079184 XP_968431.1 1195 2.8e-128 PREDICTED: histone acetyltransferase KAT8 [Tribolium castaneum]>gi|270004246|gb|EFA00694.1| hypothetical protein TcasGA2_TC003573 [Tribolium castaneum] 751216179 XM_011162727.1 187 7.83476e-91 PREDICTED: Solenopsis invicta histone acetyltransferase KAT8-like (LOC105196679), mRNA K11308 MYST1, MOF, KAT8 histone acetyltransferase MYST1 http://www.genome.jp/dbget-bin/www_bget?ko:K11308 Q9H7Z6 1047 1.6e-112 Histone acetyltransferase KAT8 OS=Homo sapiens GN=KAT8 PE=1 SV=2 PF01853 MOZ/SAS family GO:0006355 regulation of transcription, DNA-templated GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0005634 nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.51387 BP_3 26.78 1.00 1585 91079184 XP_968431.1 1840 4.5e-203 PREDICTED: histone acetyltransferase KAT8 [Tribolium castaneum]>gi|270004246|gb|EFA00694.1| hypothetical protein TcasGA2_TC003573 [Tribolium castaneum] 755929079 XM_011311259.1 304 7.2256e-156 PREDICTED: Fopius arisanus histone acetyltransferase KAT8 (LOC105270370), mRNA K11308 MYST1, MOF, KAT8 histone acetyltransferase MYST1 http://www.genome.jp/dbget-bin/www_bget?ko:K11308 Q5XI06 1508 5.8e-166 Histone acetyltransferase KAT8 OS=Rattus norvegicus GN=Kat8 PE=2 SV=1 PF00583//PF13508//PF01853//PF16719//PF14532 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//MOZ/SAS family//SAWADEE domain//Sigma-54 interaction domain GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0016747//GO:0003682//GO:0008134//GO:0008080//GO:0005524 transferase activity, transferring acyl groups other than amino-acyl groups//chromatin binding//transcription factor binding//N-acetyltransferase activity//ATP binding GO:0005667//GO:0005634//GO:0000785 transcription factor complex//nucleus//chromatin KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.51389 BP_3 132.30 3.14 2322 91087367 XP_975633.1 890 9.5e-93 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XJA3 343 1.0e-30 Protein PRRC1 OS=Danio rerio GN=prrc1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51390 BP_3 469.18 10.84 2378 91087367 XP_975633.1 855 1.1e-88 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XJA3 317 1.1e-27 Protein PRRC1 OS=Danio rerio GN=prrc1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51393 BP_3 70.61 1.98 2009 642927937 XP_008195453.1 1603 1.7e-175 PREDICTED: pregnancy zone protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63041 398 3.8e-37 Alpha-1-macroglobulin OS=Rattus norvegicus GN=A1m PE=1 SV=1 PF00207 Alpha-2-macroglobulin family -- -- GO:0004866 endopeptidase inhibitor activity -- -- -- -- Cluster-8309.51394 BP_3 2.97 2.39 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51395 BP_3 10.46 0.61 1124 478255318 ENN75544.1 334 1.4e-28 hypothetical protein YQE_07887, partial [Dendroctonus ponderosae]>gi|546683128|gb|ERL92979.1| hypothetical protein D910_10282 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZJ97 229 8.4e-18 Uncharacterized protein KIAA1143 homolog OS=Gallus gallus GN=RCJMB04_19n18 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51396 BP_3 12.00 0.38 1824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51397 BP_3 181.42 23.68 661 270010984 EFA07432.1 185 1.5e-11 mutagen-sensitive 312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05735 Thrombospondin C-terminal region GO:0007155 cell adhesion GO:0005509 calcium ion binding GO:0005576 extracellular region -- -- Cluster-8309.514 BP_3 3.00 0.43 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51401 BP_3 5640.28 136.94 2277 156564355 NP_001096056.1 2228 6.6e-248 aromatic-L-amino-acid decarboxylase [Tribolium castaneum]>gi|155675828|gb|ABU25222.1| dopa decarboxylase [Tribolium castaneum] 332373577 BT126968.1 370 0 Dendroctonus ponderosae clone DPO1325_L24 unknown mRNA K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P05031 1950 4.7e-217 Aromatic-L-amino-acid decarboxylase OS=Drosophila melanogaster GN=Ddc PE=1 SV=4 PF00282//PF01212//PF00155//PF05889 Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//Aminotransferase class I and II//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GO:0042432//GO:0006570//GO:0019752//GO:0009821//GO:0009058//GO:0006520//GO:0006558//GO:0006568//GO:0006547 indole biosynthetic process//tyrosine metabolic process//carboxylic acid metabolic process//alkaloid biosynthetic process//biosynthetic process//cellular amino acid metabolic process//L-phenylalanine metabolic process//tryptophan metabolic process//histidine metabolic process GO:0030170//GO:0016831//GO:0016740//GO:0004058//GO:0016829 pyridoxal phosphate binding//carboxy-lyase activity//transferase activity//aromatic-L-amino-acid decarboxylase activity//lyase activity -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.51404 BP_3 113.00 3.50 1850 91087279 XP_975547.1 975 1.1e-102 PREDICTED: DNA repair protein complementing XP-C cells homolog [Tribolium castaneum]>gi|270009546|gb|EFA05994.1| hypothetical protein TcasGA2_TC008820 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24595 304 2.8e-26 DNA repair protein complementing XP-C cells homolog OS=Drosophila melanogaster GN=mus210 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51408 BP_3 1.00 4.43 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02689 Helicase -- -- GO:0004386//GO:0005524 helicase activity//ATP binding -- -- -- -- Cluster-8309.51411 BP_3 939.86 13.21 3721 91093829 XP_969227.1 1839 1.4e-202 PREDICTED: transmembrane protein 161B [Tribolium castaneum] -- -- -- -- -- K08963 mtnA methylthioribose-1-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K08963 B4NG41 1425 5.7e-156 Methylthioribose-1-phosphate isomerase OS=Drosophila willistoni GN=GK22419 PE=3 SV=1 PF01008//PF04632//PF10018//PF00336 Initiation factor 2 subunit family//Fusaric acid resistance protein family//Vitamin-D-receptor interacting Mediator subunit 4//DNA polymerase (viral) C-terminal domain GO:0006357//GO:0051252//GO:0006810//GO:0044237 regulation of transcription from RNA polymerase II promoter//regulation of RNA metabolic process//transport//cellular metabolic process GO:0004523//GO:0001104 RNA-DNA hybrid ribonuclease activity//RNA polymerase II transcription cofactor activity GO:0005886//GO:0016592 plasma membrane//mediator complex KOG1468 Predicted translation initiation factor related to eIF-2B alpha/beta/delta subunits (CIG2/IDI2) Cluster-8309.51414 BP_3 1515.39 18.38 4265 808140666 XP_012171915.1 1927 9.9e-213 PREDICTED: transcriptional regulator ATRX homolog [Bombus terrestris] 642928856 XM_008197369.1 131 2.91618e-59 PREDICTED: Tribolium castaneum transcriptional regulator ATRX homolog (LOC657738), transcript variant X2, mRNA K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 Q9GQN5 1100 3.2e-118 Transcriptional regulator ATRX homolog OS=Drosophila melanogaster GN=XNP PE=1 SV=2 PF08361//PF04851//PF00176 MAATS-type transcriptional repressor, C-terminal region//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.51416 BP_3 14.43 0.57 1521 642917952 XP_008198956.1 1283 1.7e-138 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 499 5.6e-49 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.51417 BP_3 63.28 0.44 7147 478254018 ENN74310.1 6580 0.0e+00 hypothetical protein YQE_09281, partial [Dendroctonus ponderosae] 462310588 APGK01047273.1 161 1.03134e-75 Dendroctonus ponderosae Seq01047283, whole genome shotgun sequence K11446 KDM5, JARID1 histone demethylase JARID1 http://www.genome.jp/dbget-bin/www_bget?ko:K11446 Q9VMJ7 3544 0.0e+00 Lysine-specific demethylase lid OS=Drosophila melanogaster GN=lid PE=1 SV=1 PF08429//PF01388//PF06552//PF05191//PF16866//PF00628 PLU-1-like protein//ARID/BRIGHT DNA binding domain//Plant specific mitochondrial import receptor subunit TOM20//Adenylate kinase, active site lid//PHD-finger//PHD-finger GO:0045040//GO:0055114//GO:0006144//GO:0046034 protein import into mitochondrial outer membrane//oxidation-reduction process//purine nucleobase metabolic process//ATP metabolic process GO:0016706//GO:0004017//GO:0003677//GO:0005515 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//adenylate kinase activity//DNA binding//protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.5142 BP_3 42.00 1.52 1620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q54G05 130 3.6e-06 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF02203 Tar ligand binding domain homologue GO:0007165//GO:0006935 signal transduction//chemotaxis GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.51420 BP_3 131.76 4.20 1804 260799997 XP_002594923.1 439 1.5e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P17010 323 1.7e-28 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF02150//PF13465//PF00096//PF07649 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872//GO:0047134 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//protein-disulfide reductase activity GO:0005730 nucleolus -- -- Cluster-8309.51423 BP_3 216.76 14.13 1031 478252870 ENN73259.1 802 6.7e-83 hypothetical protein YQE_10155, partial [Dendroctonus ponderosae]>gi|546674747|gb|ERL86052.1| hypothetical protein D910_03466 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U145 311 2.4e-27 Transmembrane protein 64 OS=Mus musculus GN=Tmem64 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51424 BP_3 9.00 0.37 1478 857975875 CEO98054.1 239 1.9e-17 hypothetical protein PBRA_006168 [Plasmodiophora brassicae] 697088040 XM_009658636.1 1209 0 Verticillium dahliae VdLs.17 UTR2 protein partial mRNA -- -- -- -- Q4WI46 959 2.5e-102 Probable glycosidase crf2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=crf1 PE=1 SV=1 PF00187//PF00722 Chitin recognition protein//Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0008061 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding -- -- -- -- Cluster-8309.51425 BP_3 114.89 1.46 4086 642914138 XP_008201561.1 270 1.3e-20 PREDICTED: uncharacterized protein LOC103315216 isoform X1 [Tribolium castaneum]>gi|270001587|gb|EEZ98034.1| hypothetical protein TcasGA2_TC000435 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.51426 BP_3 33.00 3.19 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51428 BP_3 42.66 0.60 3704 270012487 EFA08935.1 2481 4.9e-277 hypothetical protein TcasGA2_TC006642 [Tribolium castaneum] 645037466 XM_008219044.1 217 3.94338e-107 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1544 9.1e-170 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF02214//PF00520 BTB/POZ domain//Ion transport protein GO:0055085//GO:0006811//GO:0051260 transmembrane transport//ion transport//protein homooligomerization GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.51429 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5143 BP_3 10.57 1.05 775 642931265 XP_008196504.1 614 3.2e-61 PREDICTED: high mobility group B protein 13-like [Tribolium castaneum]>gi|270012132|gb|EFA08580.1| hypothetical protein TcasGA2_TC006235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03435 125 6.6e-06 Non-histone protein 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NHP10 PE=1 SV=1 PF00340 Interleukin-1 / 18 -- -- -- -- GO:0005615 extracellular space KOG0381 HMG box-containing protein Cluster-8309.51430 BP_3 137.10 2.87 2598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51433 BP_3 36.62 0.62 3140 642918320 XP_008191458.1 395 3.2e-35 PREDICTED: uncharacterized protein LOC656340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845//PF00552 CUE domain//Integrase DNA binding domain -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- -- -- Cluster-8309.51435 BP_3 37215.56 974.73 2132 332375180 AEE62731.1 1124 6.4e-120 unknown [Dendroctonus ponderosae] 195134259 XM_002011519.1 83 6.9721e-33 Drosophila mojavensis GI11033 (Dmoj\GI11033), mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.51440 BP_3 90.29 0.48 9268 642912274 XP_008200633.1 5247 0.0e+00 PREDICTED: exportin-7 isoform X1 [Tribolium castaneum] 642912273 XM_008202411.1 991 0 PREDICTED: Tribolium castaneum exportin-7 (LOC655656), transcript variant X1, mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 4001 0.0e+00 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 PF03810//PF13414 Importin-beta N-terminal domain//TPR repeat GO:0006886 intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding -- -- KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.51441 BP_3 35.33 0.96 2074 642926820 XP_008195027.1 1979 4.5e-219 PREDICTED: uncharacterized protein LOC100142170 isoform X2 [Tribolium castaneum]>gi|270008388|gb|EFA04836.1| hypothetical protein TcasGA2_TC014886 [Tribolium castaneum] 642926819 XM_008196805.1 319 4.36019e-164 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096//PF14719 Altered inheritance of mitochondria protein 3//Phosphotyrosine interaction domain (PTB/PID) GO:0051016 barbed-end actin filament capping GO:0005515 protein binding GO:0030479 actin cortical patch -- -- Cluster-8309.51442 BP_3 125.10 4.03 1789 478259242 ENN79144.1 1148 8.9e-123 hypothetical protein YQE_04330, partial [Dendroctonus ponderosae]>gi|546678424|gb|ERL89047.1| hypothetical protein D910_06425 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGY6 912 8.5e-97 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- -- -- Cluster-8309.51445 BP_3 157.38 2.67 3135 270003145 EEZ99592.1 4002 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.3e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF04579//PF00069//PF07714 Keratin, high-sulphur matrix protein//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005198//GO:0005524 protein kinase activity//structural molecule activity//ATP binding GO:0045095 keratin filament KOG1094 Discoidin domain receptor DDR1 Cluster-8309.51446 BP_3 397.35 6.30 3332 478250819 ENN71311.1 810 2.6e-83 hypothetical protein YQE_12236, partial [Dendroctonus ponderosae]>gi|546679724|gb|ERL90139.1| hypothetical protein D910_07493 [Dendroctonus ponderosae] -- -- -- -- -- K14775 UTP30, RSL1D1 ribosome biogenesis protein UTP30 http://www.genome.jp/dbget-bin/www_bget?ko:K14775 Q9VLK2 333 2.2e-29 Ribosomal L1 domain-containing protein CG13096 OS=Drosophila melanogaster GN=CG13096 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51448 BP_3 1.00 3.39 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51450 BP_3 239.13 8.19 1699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51451 BP_3 80.88 0.38 10602 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.7e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF05430//PF00397//PF02891//PF00168//PF01155//PF00632 S-adenosyl-L-methionine-dependent methyltransferase//WW domain//MIZ/SP-RING zinc finger//C2 domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//HECT-domain (ubiquitin-transferase) GO:0055114//GO:0016567//GO:0006464 oxidation-reduction process//protein ubiquitination//cellular protein modification process GO:0016645//GO:0008270//GO:0005515//GO:0004842//GO:0016151 oxidoreductase activity, acting on the CH-NH group of donors//zinc ion binding//protein binding//ubiquitin-protein transferase activity//nickel cation binding GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.51453 BP_3 33.83 0.40 4401 189236877 XP_974696.2 3522 0.0e+00 PREDICTED: exportin-5 [Tribolium castaneum] -- -- -- -- -- K14289 XPO5 exportin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K14289 Q9HAV4 1466 1.2e-160 Exportin-5 OS=Homo sapiens GN=XPO5 PE=1 SV=1 PF00822//PF03810//PF05236 PMP-22/EMP/MP20/Claudin family//Importin-beta N-terminal domain//Transcription initiation factor TFIID component TAF4 family GO:0006352//GO:0006886 DNA-templated transcription, initiation//intracellular protein transport GO:0008536 Ran GTPase binding GO:0016021//GO:0005669 integral component of membrane//transcription factor TFIID complex KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.51455 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51456 BP_3 492.26 20.24 1464 270015295 EFA11743.1 526 9.6e-51 hypothetical protein TcasGA2_TC004233 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51457 BP_3 471.43 10.55 2445 189234456 XP_968035.2 2646 2.4e-296 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Tribolium castaneum]>gi|270001744|gb|EEZ98191.1| hypothetical protein TcasGA2_TC000620 [Tribolium castaneum] 831497549 XM_012853965.1 227 7.15523e-113 PREDICTED: Fundulus heteroclitus phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3), mRNA K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00914 Q6PF93 1885 1.7e-209 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Mus musculus GN=Pik3c3 PE=1 SV=1 PF01481//PF00454 Arterivirus nucleocapsid protein//Phosphatidylinositol 3- and 4-kinase GO:0036092//GO:0048015//GO:0046854 phosphatidylinositol-3-phosphate biosynthetic process//phosphatidylinositol-mediated signaling//phosphatidylinositol phosphorylation GO:0016303//GO:0005524//GO:0016773 1-phosphatidylinositol-3-kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0019013 viral nucleocapsid KOG0906 Phosphatidylinositol 3-kinase VPS34, involved in signal transduction Cluster-8309.51462 BP_3 32.28 1.29 1497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51468 BP_3 3.00 8.17 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51469 BP_3 55.00 2.07 1571 795010007 XP_011864749.1 707 1.1e-71 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] 462367335 APGK01026939.1 59 1.1212e-19 Dendroctonus ponderosae Seq01026949, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF13404//PF00126 AsnC-type helix-turn-helix domain//Bacterial regulatory helix-turn-helix protein, lysR family GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.51471 BP_3 5.00 2.30 395 307184971 EFN71217.1 155 2.7e-08 hypothetical protein EAG_05969, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51473 BP_3 1.00 2.59 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51477 BP_3 56.15 2.66 1308 768418838 XP_011550121.1 209 4.9e-14 PREDICTED: uncharacterized protein LOC105382004 [Plutella xylostella]>gi|768424236|ref|XP_011553062.1| PREDICTED: uncharacterized protein LOC105384507 [Plutella xylostella]>gi|768439288|ref|XP_011561267.1| PREDICTED: uncharacterized protein LOC105391485 [Plutella xylostella]>gi|768449353|ref|XP_011566757.1| PREDICTED: uncharacterized protein LOC105396454 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06017 Unconventional myosin tail, actin- and lipid-binding -- -- GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.51478 BP_3 38.30 2.47 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06017 Unconventional myosin tail, actin- and lipid-binding -- -- GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.51479 BP_3 52.69 2.09 1507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5148 BP_3 91.00 3.12 1696 642914136 XP_008201560.1 375 3.6e-33 PREDICTED: uncharacterized protein LOC103315215 [Tribolium castaneum]>gi|270002164|gb|EEZ98611.1| hypothetical protein TcasGA2_TC001133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51480 BP_3 4.00 1.46 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51481 BP_3 11.00 7.34 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.51483 BP_3 15.75 0.50 1816 270014076 EFA10524.1 250 1.2e-18 hypothetical protein TcasGA2_TC012776 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51484 BP_3 19.46 0.66 1709 768418838 XP_011550121.1 271 4.2e-21 PREDICTED: uncharacterized protein LOC105382004 [Plutella xylostella]>gi|768424236|ref|XP_011553062.1| PREDICTED: uncharacterized protein LOC105384507 [Plutella xylostella]>gi|768439288|ref|XP_011561267.1| PREDICTED: uncharacterized protein LOC105391485 [Plutella xylostella]>gi|768449353|ref|XP_011566757.1| PREDICTED: uncharacterized protein LOC105396454 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51487 BP_3 71.02 2.12 1910 189235509 XP_969871.2 1682 1.1e-184 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 550 8.5e-55 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51489 BP_3 175.04 3.40 2774 270005301 EFA01749.1 1244 1.0e-133 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.5149 BP_3 17.00 0.42 2235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51491 BP_3 58.16 1.54 2108 557757543 XP_005178504.1 2179 2.9e-242 PREDICTED: putative adenosylhomocysteinase 2 [Musca domestica]>gi|755860451|ref|XP_011290496.1| PREDICTED: putative adenosylhomocysteinase 2 [Musca domestica] 821118450 XM_004463226.2 207 8.07503e-102 PREDICTED: Dasypus novemcinctus adenosylhomocysteinase-like 2 (AHCYL2), transcript variant X6, mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q96HN2 1977 3.2e-220 Adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1 PF02254//PF02826//PF02882//PF07851//PF07992//PF13241//PF05221 TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//TMPIT-like protein//Pyridine nucleotide-disulphide oxidoreductase//Putative NAD(P)-binding//S-adenosyl-L-homocysteine hydrolase GO:0006730//GO:0006779//GO:0006555//GO:0055114//GO:0019354//GO:0046487//GO:0009396//GO:0006813 one-carbon metabolic process//porphyrin-containing compound biosynthetic process//methionine metabolic process//oxidation-reduction process//siroheme biosynthetic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//potassium ion transport GO:0043115//GO:0003824//GO:0004488//GO:0016491//GO:0051287//GO:0004013 precorrin-2 dehydrogenase activity//catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity//NAD binding//adenosylhomocysteinase activity GO:0016021 integral component of membrane KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.51494 BP_3 50.92 0.39 6561 242013664 XP_002427522.1 1953 1.5e-215 adenosylhomocysteinase, putative [Pediculus humanus corporis]>gi|212511924|gb|EEB14784.1| adenosylhomocysteinase, putative [Pediculus humanus corporis] 821118450 XM_004463226.2 166 1.57239e-78 PREDICTED: Dasypus novemcinctus adenosylhomocysteinase-like 2 (AHCYL2), transcript variant X6, mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q68FL4 1757 3.2e-194 Putative adenosylhomocysteinase 3 OS=Mus musculus GN=Ahcyl2 PE=1 SV=1 PF02882//PF02826//PF02254//PF07992//PF05221//PF13241//PF07851 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase//S-adenosyl-L-homocysteine hydrolase//Putative NAD(P)-binding//TMPIT-like protein GO:0006555//GO:0006779//GO:0055114//GO:0006730//GO:0009396//GO:0046487//GO:0006813//GO:0019354 methionine metabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//one-carbon metabolic process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//potassium ion transport//siroheme biosynthetic process GO:0016491//GO:0004488//GO:0004013//GO:0051287//GO:0043115//GO:0003824 oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//adenosylhomocysteinase activity//NAD binding//precorrin-2 dehydrogenase activity//catalytic activity GO:0016021 integral component of membrane KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.51495 BP_3 134.84 3.26 2288 642915507 XP_008190646.1 500 1.6e-47 PREDICTED: suppressor of cytokine signaling 6 [Tribolium castaneum]>gi|270004015|gb|EFA00463.1| hypothetical protein TcasGA2_TC003320 [Tribolium castaneum] -- -- -- -- -- K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q9JLY0 390 3.7e-36 Suppressor of cytokine signaling 6 OS=Mus musculus GN=Socs6 PE=1 SV=2 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.51498 BP_3 36.90 0.64 3090 91090484 XP_968697.1 281 5.2e-22 PREDICTED: DNA-directed RNA polymerase III subunit RPC4 [Tribolium castaneum]>gi|270013359|gb|EFA09807.1| hypothetical protein TcasGA2_TC011952 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05423 153 1.5e-08 DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens GN=POLR3D PE=1 SV=2 PF05132 RNA polymerase III RPC4 GO:0006206//GO:0006144//GO:0006383//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005666 nucleolus//DNA-directed RNA polymerase III complex -- -- Cluster-8309.515 BP_3 21.00 0.36 3105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51501 BP_3 66.87 1.34 2693 91090484 XP_968697.1 513 5.7e-49 PREDICTED: DNA-directed RNA polymerase III subunit RPC4 [Tribolium castaneum]>gi|270013359|gb|EFA09807.1| hypothetical protein TcasGA2_TC011952 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05423 164 6.9e-10 DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens GN=POLR3D PE=1 SV=2 PF05132 RNA polymerase III RPC4 GO:0006206//GO:0006383//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005666 nucleolus//DNA-directed RNA polymerase III complex -- -- Cluster-8309.51502 BP_3 585.87 5.89 5085 270016078 EFA12526.1 1340 1.4e-144 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7LHG5 939 1.8e-99 Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-I PE=3 SV=2 PF02406//PF00665//PF03539 MmoB/DmpM family//Integrase core domain//Spumavirus aspartic protease (A9) GO:0015074//GO:0006725//GO:0006508 DNA integration//cellular aromatic compound metabolic process//proteolysis GO:0004497//GO:0004190 monooxygenase activity//aspartic-type endopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.51503 BP_3 34.07 0.34 5143 270016078 EFA12526.1 1340 1.4e-144 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7LHG5 939 1.8e-99 Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-I PE=3 SV=2 PF02406//PF00665//PF03539 MmoB/DmpM family//Integrase core domain//Spumavirus aspartic protease (A9) GO:0015074//GO:0006725//GO:0006508 DNA integration//cellular aromatic compound metabolic process//proteolysis GO:0004497//GO:0004190 monooxygenase activity//aspartic-type endopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.51505 BP_3 125.53 2.86 2407 607361054 EZA55356.1 530 5.5e-51 Putative nuclease HARBI1, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- Q6AZB8 284 7.5e-24 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF03213//PF01609 Poxvirus P35 protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity GO:0019031 viral envelope -- -- Cluster-8309.51509 BP_3 107.04 4.15 1535 642930251 XP_971223.2 984 7.9e-104 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 132 2.0e-06 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51513 BP_3 15.00 0.39 2160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51514 BP_3 253.41 3.48 3800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.51521 BP_3 956.12 40.56 1428 91076680 XP_971073.1 809 1.4e-83 PREDICTED: AP-1 complex subunit sigma-2 isoform X1 [Tribolium castaneum]>gi|270001880|gb|EEZ98327.1| hypothetical protein TcasGA2_TC000781 [Tribolium castaneum] 242011937 XM_002426655.1 178 7.1698e-86 Pediculus humanus corporis clathrin coat assembly protein ap19, putative, mRNA K12394 AP1S1_2 AP-1 complex subunit sigma 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12394 P56377 680 5.4e-70 AP-1 complex subunit sigma-2 OS=Homo sapiens GN=AP1S2 PE=1 SV=1 -- -- GO:0006886//GO:0016192//GO:0015031 intracellular protein transport//vesicle-mediated transport//protein transport GO:0008565 protein transporter activity GO:0030117 membrane coat KOG0934 Clathrin adaptor complex, small subunit Cluster-8309.51525 BP_3 113.76 3.11 2057 270013936 EFA10384.1 1688 2.5e-185 hypothetical protein TcasGA2_TC012615 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2RUV4 717 4.0e-74 Rho GTPase-activating protein 21 OS=Xenopus tropicalis GN=arhgap21 PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.51527 BP_3 93.74 1.84 2747 642927091 XP_008195134.1 2880 0.0e+00 PREDICTED: rhophilin-2 isoform X3 [Tribolium castaneum]>gi|270010028|gb|EFA06476.1| hypothetical protein TcasGA2_TC009368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TNR1 1240 1.2e-134 Rhophilin-2 OS=Danio rerio GN=rhpn2 PE=2 SV=1 PF13180//PF02185//PF00595 PDZ domain//Hr1 repeat//PDZ domain (Also known as DHR or GLGF) GO:0007165 signal transduction GO:0005515 protein binding GO:0005622 intracellular KOG2220 Predicted signal transduction protein Cluster-8309.51528 BP_3 662.61 12.70 2806 189233695 XP_001812208.1 496 5.6e-47 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 371 7.2e-34 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.51530 BP_3 5.00 1.90 418 270013391 EFA09839.1 584 5.2e-58 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 694449459 XM_009352104.1 67 1.00427e-24 PREDICTED: Pyrus x bretschneideri uncharacterized LOC103941904 (LOC103941904), partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51533 BP_3 450.00 9.88 2487 91082983 XP_974176.1 1153 3.2e-123 PREDICTED: tetratricopeptide repeat protein 19 homolog, mitochondrial [Tribolium castaneum]>gi|270007637|gb|EFA04085.1| hypothetical protein TcasGA2_TC014319 [Tribolium castaneum] -- -- -- -- -- K18169 TTC19 tetratricopeptide repeat protein 19, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K18169 Q8SYD0 577 8.2e-58 Tetratricopeptide repeat protein 19 homolog, mitochondrial OS=Drosophila melanogaster GN=Ttc19 PE=2 SV=1 PF08631//PF13374//PF00515//PF13181//PF13414//PF13176 Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0051321 meiotic cell cycle GO:0005515 protein binding -- -- KOG1840 Kinesin light chain Cluster-8309.51541 BP_3 1833.49 15.74 5907 642938800 XP_008199891.1 1155 4.5e-123 PREDICTED: collagen alpha-1(V) chain-like [Tribolium castaneum] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 P20908 777 1.3e-80 Collagen alpha-1(V) chain OS=Homo sapiens GN=COL5A1 PE=1 SV=3 PF01410//PF02948 Fibrillar collagen C-terminal domain//Amelogenin GO:0007275 multicellular organismal development GO:0005201 extracellular matrix structural constituent GO:0005578//GO:0005581 proteinaceous extracellular matrix//collagen trimer -- -- Cluster-8309.51542 BP_3 67.12 3.99 1102 646722307 KDR23320.1 765 1.4e-78 Collagen alpha-1(XI) chain, partial [Zootermopsis nevadensis] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 Q61245 432 2.4e-41 Collagen alpha-1(XI) chain OS=Mus musculus GN=Col11a1 PE=1 SV=2 PF00552//PF01410 Integrase DNA binding domain//Fibrillar collagen C-terminal domain -- -- GO:0003676//GO:0005201 nucleic acid binding//extracellular matrix structural constituent GO:0005578//GO:0005581 proteinaceous extracellular matrix//collagen trimer -- -- Cluster-8309.51543 BP_3 622.39 5.58 5669 642938800 XP_008199891.1 1187 8.4e-127 PREDICTED: collagen alpha-1(V) chain-like [Tribolium castaneum] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 P20908 777 1.2e-80 Collagen alpha-1(V) chain OS=Homo sapiens GN=COL5A1 PE=1 SV=3 PF02948//PF01410 Amelogenin//Fibrillar collagen C-terminal domain GO:0007275 multicellular organismal development GO:0005201 extracellular matrix structural constituent GO:0005581//GO:0005578 collagen trimer//proteinaceous extracellular matrix -- -- Cluster-8309.51545 BP_3 37.00 1.18 1802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13174 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51546 BP_3 75.31 0.96 4073 91082137 XP_966595.1 1464 4.6e-159 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 178 2.0772e-85 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1193 5.0e-129 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.51547 BP_3 380.76 5.29 3764 91081013 XP_975219.1 1786 1.9e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 2.3e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.51554 BP_3 13.75 0.39 1986 642927844 XP_008195423.1 951 6.8e-100 PREDICTED: INO80 complex subunit D-B-like [Tribolium castaneum]>gi|270010242|gb|EFA06690.1| hypothetical protein TcasGA2_TC009621 [Tribolium castaneum] -- -- -- -- -- K11668 INO80D INO80 complex subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K11668 Q66JY2 239 1.0e-18 INO80 complex subunit D OS=Mus musculus GN=Ino80d PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51555 BP_3 89.80 8.30 813 642931789 XP_008196729.1 275 6.8e-22 PREDICTED: chromatin accessibility complex protein 1 [Tribolium castaneum] -- -- -- -- -- K11656 CHRAC1, CHRAC15 chromatin accessibility complex protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11656 Q9NRG0 184 1.0e-12 Chromatin accessibility complex protein 1 OS=Homo sapiens GN=CHRAC1 PE=1 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1657 CCAAT-binding factor, subunit C (HAP5) Cluster-8309.51558 BP_3 124.93 1.78 3681 91094203 XP_971608.1 1093 4.3e-116 PREDICTED: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [Tribolium castaneum]>gi|270010912|gb|EFA07360.1| hypothetical protein TcasGA2_TC015960 [Tribolium castaneum] 826492697 XM_012684964.1 53 5.75751e-16 PREDICTED: Monomorium pharaonis probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (LOC105838989), mRNA K03847 ALG12 alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03847 Q9VH78 740 1.5e-76 Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster GN=CG8412 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) Cluster-8309.51559 BP_3 31.94 3.23 769 646640094 KDQ71559.1 200 3.2e-13 hypothetical protein L798_09467 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51560 BP_3 1728.52 41.26 2311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51561 BP_3 3.00 1.34 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51565 BP_3 55.70 1.02 2936 122114669 NP_001073624.1 3027 0.0e+00 Sip1/TFIP11 interacting protein [Tribolium castaneum]>gi|85363108|gb|ABC69932.1| STIP [Tribolium castaneum] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q9Y103 1539 2.7e-169 Septin-interacting protein 1 OS=Drosophila melanogaster GN=sip1 PE=1 SV=1 PF07842//PF01585 GC-rich sequence DNA-binding factor-like protein//G-patch domain GO:0008380//GO:0006355//GO:0006397 RNA splicing//regulation of transcription, DNA-templated//mRNA processing GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0005681//GO:0005634 spliceosomal complex//nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.51572 BP_3 410.11 5.32 4007 642922588 XP_008193239.1 1439 3.6e-156 PREDICTED: protein AF-10 isoform X2 [Tribolium castaneum] 642922589 XM_008195018.1 320 2.36023e-164 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X6, mRNA -- -- -- -- P55197 839 5.5e-88 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG0956 PHD finger protein AF10 Cluster-8309.51574 BP_3 9.00 1.42 598 91094481 XP_970829.1 165 2.9e-09 PREDICTED: WD and tetratricopeptide repeats protein 1 [Tribolium castaneum]>gi|270000741|gb|EEZ97188.1| hypothetical protein TcasGA2_TC004375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51575 BP_3 100.60 3.67 1613 642940167 XP_008194639.1 623 6.0e-62 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXM1 253 2.0e-20 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens GN=LRIG3 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.51578 BP_3 8.22 0.43 1221 91095131 XP_971500.1 186 2.1e-11 PREDICTED: transforming growth factor-beta-induced protein ig-h3 [Tribolium castaneum]>gi|270015611|gb|EFA12059.1| hypothetical protein TcasGA2_TC012903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51580 BP_3 161.00 2.28 3694 332374070 AEE62176.1 1027 2.0e-108 unknown [Dendroctonus ponderosae] -- -- -- -- -- K12259 SMOX, PAO5 spermine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K12259 Q9NWM0 381 6.5e-35 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF00070//PF01593//PF12831//PF01266//PF06152//PF07992 Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Phage minor capsid protein 2//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491//GO:0005198 oxidoreductase activity//structural molecule activity GO:0019028 viral capsid KOG0685 Flavin-containing amine oxidase Cluster-8309.51581 BP_3 11.08 0.94 859 478256794 ENN76972.1 147 5.0e-07 hypothetical protein YQE_06540, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51584 BP_3 11.94 1.30 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51586 BP_3 99.90 1.68 3159 332373870 AEE62076.1 1581 9.7e-173 unknown [Dendroctonus ponderosae] 198456406 XM_001360273.2 35 5.00327e-06 Drosophila pseudoobscura pseudoobscura GA13487 (Dpse\GA13487), partial mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 909 3.3e-96 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.51589 BP_3 13.60 0.32 2337 270010353 EFA06801.1 1514 4.2e-165 hypothetical protein TcasGA2_TC009740 [Tribolium castaneum] 665795469 XM_008547261.1 239 1.45864e-119 PREDICTED: Microplitis demolitor cyclin-dependent kinase 5 (LOC103569778), mRNA K02090 CDK5 cyclin-dependent kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02090 P51166 1283 1.1e-139 Cyclin-dependent-like kinase 5 OS=Xenopus laevis GN=cdk5 PE=2 SV=1 PF00069//PF02109//PF07714 Protein kinase domain//DAD family//Protein tyrosine kinase GO:0018279//GO:0006468 protein N-linked glycosylation via asparagine//protein phosphorylation GO:0005524//GO:0004579//GO:0004672 ATP binding//dolichyl-diphosphooligosaccharide-protein glycotransferase activity//protein kinase activity GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex KOG0662 Cyclin-dependent kinase CDK5 Cluster-8309.51590 BP_3 19.00 0.43 2412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02378//PF08926 Phosphotransferase system, EIIC//Domain of unknown function (DUF1908) GO:0008643//GO:0009401//GO:0016310//GO:0006468//GO:0009069 carbohydrate transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0000287//GO:0008982//GO:0005524 protein serine/threonine kinase activity//magnesium ion binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//ATP binding GO:0009357//GO:0016020 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane -- -- Cluster-8309.51591 BP_3 75.74 2.52 1740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51593 BP_3 20.30 1.86 818 189234785 XP_975008.2 818 7.5e-85 PREDICTED: acetyl-CoA acetyltransferase, mitochondrial [Tribolium castaneum]>gi|270001523|gb|EEZ97970.1| hypothetical protein TcasGA2_TC000365 [Tribolium castaneum] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 425 1.1e-40 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF03534//PF02803//PF00462 Salmonella virulence plasmid 65kDa B protein//Thiolase, C-terminal domain//Glutaredoxin GO:0008152//GO:0006118//GO:0045454 metabolic process//obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0016747 protein disulfide oxidoreductase activity//electron carrier activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005737 cytoplasm KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.51595 BP_3 13.00 0.46 1651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51596 BP_3 799.78 11.79 3562 270007542 EFA03990.1 2387 3.8e-266 hypothetical protein TcasGA2_TC014139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLB0 1099 3.5e-118 MAGUK p55 subfamily member 6 OS=Mus musculus GN=Mpp6 PE=1 SV=1 PF13180//PF03193//PF00595//PF14604//PF00018 PDZ domain//Protein of unknown function, DUF258//PDZ domain (Also known as DHR or GLGF)//Variant SH3 domain//SH3 domain -- -- GO:0005525//GO:0005515//GO:0003924 GTP binding//protein binding//GTPase activity -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.51597 BP_3 2.00 0.49 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.516 BP_3 4.00 0.34 866 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5160 BP_3 32.47 0.32 5239 642913905 XP_008201208.1 1550 6.3e-169 PREDICTED: putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 isoform X1 [Tribolium castaneum]>gi|270001644|gb|EEZ98091.1| hypothetical protein TcasGA2_TC000504 [Tribolium castaneum] -- -- -- -- -- K13718 OTUD4 OTU domain-containing protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13718 Q9D8C3 456 1.9e-43 Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 OS=Mus musculus GN=Alg13 PE=2 SV=2 PF00757//PF12250 Furin-like cysteine rich region//Arabinofuranosyltransferase N terminal GO:0007169//GO:0006468//GO:0044038 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation//cell wall macromolecule biosynthetic process GO:0004714//GO:0005524//GO:0016757 transmembrane receptor protein tyrosine kinase activity//ATP binding//transferase activity, transferring glycosyl groups GO:0016020//GO:0016021//GO:0005886 membrane//integral component of membrane//plasma membrane KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.51604 BP_3 43.93 0.73 3175 546679384 ERL89859.1 2202 9.5e-245 hypothetical protein D910_07218, partial [Dendroctonus ponderosae] -- -- -- -- -- K11421 SETDB1 histone-lysine N-methyltransferase SETDB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11421 Q28Z18 942 5.0e-100 Histone-lysine N-methyltransferase eggless OS=Drosophila pseudoobscura pseudoobscura GN=egg PE=3 SV=2 PF00856//PF05033//PF01429 SET domain//Pre-SET motif//Methyl-CpG binding domain GO:0034968//GO:0006479//GO:0006554 histone lysine methylation//protein methylation//lysine catabolic process GO:0003677//GO:0018024//GO:0005515//GO:0008270 DNA binding//histone-lysine N-methyltransferase activity//protein binding//zinc ion binding GO:0005634 nucleus KOG1141 Predicted histone methyl transferase Cluster-8309.51605 BP_3 12.73 0.47 1611 478254824 ENN75060.1 1179 2.0e-126 hypothetical protein YQE_08373, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DKP5 692 2.5e-71 WD repeat-containing protein 13 OS=Pan troglodytes GN=WDR13 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.51606 BP_3 5.62 0.71 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51608 BP_3 308.43 3.45 4602 642925191 XP_008194463.1 3175 0.0e+00 PREDICTED: myelin regulatory factor isoform X4 [Tribolium castaneum]>gi|270008766|gb|EFA05214.1| hypothetical protein TcasGA2_TC015354 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.23893e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1228 5.0e-133 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF05224//PF10152 NDT80 / PhoG like DNA-binding family//Predicted coiled-coil domain-containing protein (DUF2360) -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.51609 BP_3 125.09 0.70 8967 642933755 XP_008191527.1 3915 0.0e+00 PREDICTED: huntingtin-like [Tribolium castaneum] -- -- -- -- -- K04533 HD huntingtin http://www.genome.jp/dbget-bin/www_bget?ko:K04533 P42858 1659 1.0e-182 Huntingtin OS=Homo sapiens GN=HTT PE=1 SV=2 PF02985//PF08715 HEAT repeat//Papain like viral protease GO:0006508 proteolysis GO:0016740//GO:0008242//GO:0005515//GO:0004197 transferase activity//omega peptidase activity//protein binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.51610 BP_3 21.08 1.02 1287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51614 BP_3 239.33 6.15 2168 189238634 XP_001811204.1 2185 6.1e-243 PREDICTED: tubulin gamma-1 chain isoform X2 [Tribolium castaneum] 675658452 XM_002747994.2 219 1.77326e-108 PREDICTED: Callithrix jacchus tubulin, gamma 1 (TUBG1), mRNA K10389 TUBG tubulin gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10389 Q0VCD2 1927 2.1e-214 Tubulin gamma-1 chain OS=Bos taurus GN=TUBG1 PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1374 Gamma tubulin Cluster-8309.51615 BP_3 156.50 3.23 2629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51616 BP_3 72.50 1.49 2644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51618 BP_3 22.36 0.42 2868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51620 BP_3 82.96 1.72 2617 270017034 EFA13480.1 707 1.8e-71 hypothetical protein TcasGA2_TC002031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MU95 275 9.0e-23 Beta-1,3-glucan-binding protein OS=Plodia interpunctella PE=1 SV=1 PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.51622 BP_3 73.31 1.96 2092 478253546 ENN73864.1 744 7.3e-76 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 634 1.7e-64 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF03435//PF01266//PF13241//PF02558//PF01134//PF00899//PF03721//PF00070//PF01494//PF07992//PF02254 Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//Putative NAD(P)-binding//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A//ThiF family//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//TrkA-N domain GO:0055114//GO:0008033//GO:0006779//GO:0006813//GO:0019354//GO:0015940 oxidation-reduction process//tRNA processing//porphyrin-containing compound biosynthetic process//potassium ion transport//siroheme biosynthetic process//pantothenate biosynthetic process GO:0008641//GO:0050660//GO:0008677//GO:0051287//GO:0016616//GO:0016491//GO:0071949//GO:0043115 small protein activating enzyme activity//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//FAD binding//precorrin-2 dehydrogenase activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.51626 BP_3 30.10 0.45 3546 642926212 XP_008194831.1 2213 5.6e-246 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926214|ref|XP_008194832.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926216|ref|XP_973431.2| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926218|ref|XP_008194833.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926220|ref|XP_008194834.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926222|ref|XP_008194835.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] 749752848 XM_011140486.1 61 1.98002e-20 PREDICTED: Harpegnathos saltator putative fatty acyl-CoA reductase CG5065 (LOC105182795), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1491 1.2e-163 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01118//PF01370//PF03015 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Male sterility protein GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process GO:0080019//GO:0016620//GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.51627 BP_3 33.47 0.58 3073 642926212 XP_008194831.1 1900 9.6e-210 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926214|ref|XP_008194832.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926216|ref|XP_973431.2| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926218|ref|XP_008194833.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926220|ref|XP_008194834.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926222|ref|XP_008194835.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1277 6.9e-139 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.51628 BP_3 37.93 5.07 652 642924886 XP_008194084.1 416 2.4e-38 PREDICTED: serine/threonine-protein kinase MST4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 -- -- -- -- PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- -- -- Cluster-8309.51629 BP_3 19.75 0.79 1495 642921104 XP_008192691.1 1112 1.1e-118 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 A0JNI5 597 2.4e-60 CLK4-associating serine/arginine rich protein OS=Bos taurus GN=CLASRP PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2548 SWAP mRNA splicing regulator Cluster-8309.5163 BP_3 99.11 3.69 1585 642929142 XP_008195711.1 1656 9.7e-182 PREDICTED: transcription factor AP-2 isoform X1 [Tribolium castaneum] 597797984 XM_007260483.1 100 1.82746e-42 PREDICTED: Astyanax mexicanus transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (tfap2b), mRNA K09179 TFAP2E transcription factor AP-2 epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09179 Q2T9K2 867 1.2e-91 Transcription factor AP-2-epsilon OS=Xenopus laevis GN=tfap2e PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3811 Transcription factor AP-2 Cluster-8309.51630 BP_3 73.76 2.85 1538 642924864 XP_008194073.1 138 9.9e-06 PREDICTED: uncharacterized protein LOC656855 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51632 BP_3 1209.51 25.57 2572 642916217 XP_008190934.1 3030 0.0e+00 PREDICTED: calpain-C [Tribolium castaneum] 195479179 XM_002100759.1 39 2.42969e-08 Drosophila yakuba GE17262 (Dyak\GE17262), partial mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 Q9VXH6 1662 1.3e-183 Calpain-C OS=Drosophila melanogaster GN=CalpC PE=1 SV=4 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.51634 BP_3 1.00 0.57 373 478253099 ENN73472.1 220 7.5e-16 hypothetical protein YQE_09897, partial [Dendroctonus ponderosae] -- -- -- -- -- K01331 C1S complement component 1, s subcomponent http://www.genome.jp/dbget-bin/www_bget?ko:K01331 P05049 179 1.7e-12 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.51635 BP_3 8.65 0.38 1399 642912421 XP_008193352.1 702 3.6e-71 PREDICTED: serine protease snake-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 459 2.2e-44 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.51641 BP_3 29.05 0.70 2306 642919263 XP_008191800.1 985 9.1e-104 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8NFU1 646 7.6e-66 Bestrophin-2 OS=Homo sapiens GN=BEST2 PE=2 SV=1 PF08283 Geminivirus rep protein central domain GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.51644 BP_3 48.51 3.11 1043 478256686 ENN76868.1 708 5.4e-72 hypothetical protein YQE_06709, partial [Dendroctonus ponderosae]>gi|546685117|gb|ERL94644.1| hypothetical protein D910_11919 [Dendroctonus ponderosae] -- -- -- -- -- K00944 AK3 nucleoside-triphosphate--adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00944 Q9WTP7 485 1.6e-47 GTP:AMP phosphotransferase AK3, mitochondrial OS=Mus musculus GN=Ak3 PE=1 SV=3 PF05191 Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017 adenylate kinase activity -- -- KOG3078 Adenylate kinase Cluster-8309.51645 BP_3 590.86 7.11 4295 642919071 XP_008191721.1 4744 0.0e+00 PREDICTED: MAP kinase-activating death domain protein isoform X2 [Tribolium castaneum] 780680996 XM_011699227.1 91 5.05546e-37 PREDICTED: Wasmannia auropunctata MAP kinase-activating death domain protein (LOC105455707), transcript variant X7, mRNA -- -- -- -- Q9VXY2 3272 0.0e+00 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane KOG3570 MAPK-activating protein DENN Cluster-8309.51646 BP_3 250.12 2.94 4392 642919071 XP_008191721.1 3346 0.0e+00 PREDICTED: MAP kinase-activating death domain protein isoform X2 [Tribolium castaneum] 780680996 XM_011699227.1 91 5.1706e-37 PREDICTED: Wasmannia auropunctata MAP kinase-activating death domain protein (LOC105455707), transcript variant X7, mRNA -- -- -- -- Q9VXY2 2480 3.1e-278 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane KOG3570 MAPK-activating protein DENN Cluster-8309.51653 BP_3 115.01 1.39 4292 91084565 XP_973665.1 3728 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 41 homolog [Tribolium castaneum]>gi|270008656|gb|EFA05104.1| hypothetical protein TcasGA2_TC015204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5KU39 1694 4.3e-187 Vacuolar protein sorting-associated protein 41 homolog OS=Mus musculus GN=Vps41 PE=2 SV=1 PF17122//PF00400//PF14634//PF12678//PF17123//PF00637//PF13639 Zinc-finger//WD domain, G-beta repeat//zinc-RING finger domain//RING-H2 zinc finger//RING-like zinc finger//Region in Clathrin and VPS//Ring finger domain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005622 intracellular KOG2066 Vacuolar assembly/sorting protein VPS41 Cluster-8309.51654 BP_3 571.83 7.08 4183 91084565 XP_973665.1 3739 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 41 homolog [Tribolium castaneum]>gi|270008656|gb|EFA05104.1| hypothetical protein TcasGA2_TC015204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5KU39 1694 4.2e-187 Vacuolar protein sorting-associated protein 41 homolog OS=Mus musculus GN=Vps41 PE=2 SV=1 PF17123//PF12678//PF14634//PF00400//PF17122//PF13639//PF00637 RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//WD domain, G-beta repeat//Zinc-finger//Ring finger domain//Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005622 intracellular KOG2066 Vacuolar assembly/sorting protein VPS41 Cluster-8309.51655 BP_3 19.17 0.42 2515 642933990 XP_008197594.1 414 1.6e-37 PREDICTED: vesicle-fusing ATPase 1-like [Tribolium castaneum]>gi|642933992|ref|XP_008197595.1| PREDICTED: vesicle-fusing ATPase 1-like [Tribolium castaneum]>gi|270013652|gb|EFA10100.1| hypothetical protein TcasGA2_TC012279 [Tribolium castaneum] -- -- -- -- -- K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 305 2.9e-26 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF08752//PF01299 Coatomer gamma subunit appendage platform subdomain//Lysosome-associated membrane glycoprotein (Lamp) GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005524//GO:0017111//GO:0005198 ATP binding//nucleoside-triphosphatase activity//structural molecule activity GO:0016020//GO:0030126 membrane//COPI vesicle coat -- -- Cluster-8309.51656 BP_3 760.22 12.86 3141 91083297 XP_974591.1 1894 4.9e-209 PREDICTED: probable cysteine desulfurase, mitochondrial [Tribolium castaneum]>gi|270007737|gb|EFA04185.1| hypothetical protein TcasGA2_TC014434 [Tribolium castaneum] -- -- -- -- -- K04487 iscS, NFS1 cysteine desulfurase http://www.genome.jp/dbget-bin/www_bget?ko:K04487 Q9VKD3 1773 2.2e-196 Probable cysteine desulfurase, mitochondrial OS=Drosophila melanogaster GN=CG12264 PE=2 SV=1 PF01926//PF08477//PF00025//PF03193//PF00910//PF04670//PF00071//PF00282//PF01212 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Protein of unknown function, DUF258//RNA helicase//Gtr1/RagA G protein conserved region//Ras family//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase GO:0008152//GO:0019752//GO:0007264//GO:0006520 metabolic process//carboxylic acid metabolic process//small GTPase mediated signal transduction//cellular amino acid metabolic process GO:0003723//GO:0003824//GO:0016831//GO:0030170//GO:0003924//GO:0005525//GO:0003724//GO:0016829 RNA binding//catalytic activity//carboxy-lyase activity//pyridoxal phosphate binding//GTPase activity//GTP binding//RNA helicase activity//lyase activity -- -- KOG1549 Cysteine desulfurase NFS1 Cluster-8309.51659 BP_3 51.06 0.39 6573 546679060 ERL89583.1 2516 7.7e-281 hypothetical protein D910_06948 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 2.2e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF07728//PF01695//PF06068//PF01057//PF05496//PF00439//PF00004//PF07724//PF00005//PF04851//PF00910 AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Bromodomain//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ABC transporter//Type III restriction enzyme, res subunit//RNA helicase GO:0006310//GO:0019079//GO:0006281 DNA recombination//viral genome replication//DNA repair GO:0016887//GO:0003724//GO:0009378//GO:0003723//GO:0003678//GO:0005524//GO:0016787//GO:0003677//GO:0005515 ATPase activity//RNA helicase activity//four-way junction helicase activity//RNA binding//DNA helicase activity//ATP binding//hydrolase activity//DNA binding//protein binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.51665 BP_3 137.42 0.80 8552 478255880 ENN76088.1 1556 2.1e-169 hypothetical protein YQE_07459, partial [Dendroctonus ponderosae]>gi|546680428|gb|ERL90694.1| hypothetical protein D910_08041 [Dendroctonus ponderosae] 642916712 XM_001813000.2 336 6.45286e-173 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100141653), mRNA -- -- -- -- Q9W0K7 653 4.4e-66 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF05225 helix-turn-helix, Psq domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.51666 BP_3 56.55 9.20 588 270004298 EFA00746.1 810 4.5e-84 hypothetical protein TcasGA2_TC003628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BVD5 440 1.5e-42 MAGUK p55 subfamily member 7 OS=Mus musculus GN=Mpp7 PE=2 SV=2 PF14604//PF00595//PF00018//PF13180 Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51669 BP_3 283.59 3.16 4615 91078526 XP_970233.1 4667 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 9.29029e-20 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3270 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF00472 RF-1 domain GO:0006415//GO:0006449 translational termination//regulation of translational termination GO:0003747 translation release factor activity GO:0018444//GO:0005840 translation release factor complex//ribosome -- -- Cluster-8309.5167 BP_3 3.00 0.62 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51672 BP_3 11.00 2.08 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51678 BP_3 740.96 34.83 1317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51680 BP_3 8.00 3.78 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51683 BP_3 446.11 2.82 7929 641658099 XP_008180596.1 937 1.2e-97 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 642920823 XM_008194352.1 69 1.58941e-24 PREDICTED: Tribolium castaneum transcription factor SPT20 homolog (LOC661459), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 886 3.9e-93 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00096//PF16622//PF12090//PF13912//PF02892//PF00412//PF12833//PF04810//PF13465 Zinc finger, C2H2 type//zinc-finger C2H2-type//Spt20 family//C2H2-type zinc finger//BED zinc finger//LIM domain//Helix-turn-helix domain//Sec23/Sec24 zinc finger//Zinc-finger double domain GO:0006888//GO:0006886//GO:0006355 ER to Golgi vesicle-mediated transport//intracellular protein transport//regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003712//GO:0008270//GO:0046872//GO:0003700 DNA binding//sequence-specific DNA binding//transcription cofactor activity//zinc ion binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0030127//GO:0005667//GO:0000124 COPII vesicle coat//transcription factor complex//SAGA complex -- -- Cluster-8309.51684 BP_3 41.67 1.12 2082 546683632 ERL93420.1 963 2.9e-101 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 Q9V407 259 5.2e-21 Axin OS=Drosophila melanogaster GN=Axn PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51687 BP_3 5.00 1.26 483 -- -- -- -- -- 60649821 AJ829764.1 101 1.47606e-43 Otiorhynchus sulcatus partial cbh1 gene for cellulose 1,4-beta-cellobiosidase, six exons -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51688 BP_3 21.24 1.16 1172 642937910 XP_008200354.1 882 4.1e-92 PREDICTED: zinc finger RNA-binding protein [Tribolium castaneum] -- -- -- -- -- K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 O88532 485 1.8e-47 Zinc finger RNA-binding protein OS=Mus musculus GN=Zfr PE=1 SV=2 PF00096//PF06220//PF03153 Zinc finger, C2H2 type//U1 zinc finger//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.51690 BP_3 22.66 0.60 2125 315570560 ADU33284.1 2397 1.6e-267 glycoside hydrolase family protein 48 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P50899 1926 2.6e-214 Exoglucanase B OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) GN=cbhB PE=1 SV=1 PF02011 Glycosyl hydrolase family 48 GO:0030245//GO:0005975//GO:0005982//GO:0005985 cellulose catabolic process//carbohydrate metabolic process//starch metabolic process//sucrose metabolic process GO:0008810//GO:0004553 cellulase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.51694 BP_3 129.41 0.95 6886 675371505 KFM64407.1 685 1.7e-68 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P16425 223 2.6e-16 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF13949 ALIX V-shaped domain binding to HIV -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51695 BP_3 177.34 1.88 4841 675371881 KFM64783.1 284 3.7e-22 Hypothetical protein in type-1 retrotransposable element R1DM, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P16425 223 1.8e-16 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF01609 Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-8309.51696 BP_3 46.14 0.40 5872 675371505 KFM64407.1 793 4.2e-81 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q96DM1 227 7.5e-17 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF01609 Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-8309.51698 BP_3 51.26 1.40 2057 546676350 ERL87377.1 1897 1.4e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.2e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.51699 BP_3 154.45 0.92 8424 642929587 XP_975389.2 4308 0.0e+00 PREDICTED: uncharacterized protein LOC664289 isoform X3 [Tribolium castaneum] 642929586 XM_970296.2 70 4.69634e-25 PREDICTED: Tribolium castaneum uncharacterized LOC664289 (LOC664289), transcript variant X3, mRNA -- -- -- -- Q14687 146 2.6e-07 Genetic suppressor element 1 OS=Homo sapiens GN=GSE1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.517 BP_3 7.00 0.32 1338 15425681 BAB64297.1 1667 4.4e-183 I-connectin [Procambarus clarkii] -- -- -- -- -- -- -- -- -- Q9I7U4 704 8.3e-73 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF13895//PF00041//PF16656//PF01108//PF01153 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Tissue factor//Glypican GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0043395//GO:0046872//GO:0003993 protein binding//heparan sulfate proteoglycan binding//metal ion binding//acid phosphatase activity GO:0016020//GO:0005578 membrane//proteinaceous extracellular matrix KOG0613 Projectin/twitchin and related proteins Cluster-8309.5170 BP_3 2.00 0.50 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51700 BP_3 132.80 3.89 1936 642917151 XP_008191139.1 2389 1.2e-266 PREDICTED: F-box-like/WD repeat-containing protein TBL1XR1 [Tribolium castaneum]>gi|270004371|gb|EFA00819.1| hypothetical protein TcasGA2_TC003706 [Tribolium castaneum] 442624961 NM_057981.4 286 8.98813e-146 Drosophila melanogaster ebi (ebi), mRNA K04508 TBL1 transducin (beta)-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04508 Q8BHJ5 2046 2.9e-228 F-box-like/WD repeat-containing protein TBL1XR1 OS=Mus musculus GN=Tbl1xr1 PE=1 SV=1 PF04053//PF08513//PF00457//PF00400//PF01588 Coatomer WD associated region//LisH//Glycosyl hydrolases family 11//WD domain, G-beta repeat//Putative tRNA binding domain GO:0016192//GO:0006886//GO:0005975 vesicle-mediated transport//intracellular protein transport//carbohydrate metabolic process GO:0005515//GO:0000049//GO:0005198//GO:0004553 protein binding//tRNA binding//structural molecule activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0030117 membrane coat KOG0273 Beta-transducin family (WD-40 repeat) protein Cluster-8309.51703 BP_3 462.44 1.92 11875 478250833 ENN71323.1 994 4.2e-104 hypothetical protein YQE_11983, partial [Dendroctonus ponderosae]>gi|478259213|gb|ENN79116.1| hypothetical protein YQE_04427, partial [Dendroctonus ponderosae] 642918718 XM_008193332.1 122 8.21846e-54 PREDICTED: Tribolium castaneum zinc finger protein jing homolog (LOC658276), transcript variant X2, mRNA K17452 AEBP2 zinc finger protein AEBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K17452 Q17PR1 474 3.5e-45 Zinc finger protein jing homolog OS=Aedes aegypti GN=AAEL000263 PE=3 SV=1 PF05399//PF16622//PF13465//PF00096 Ectropic viral integration site 2A protein (EVI2A)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.51706 BP_3 4.00 2.84 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5171 BP_3 15316.90 2156.74 634 478258611 ENN78661.1 429 7.4e-40 hypothetical protein YQE_04833, partial [Dendroctonus ponderosae]>gi|546685768|gb|ERL95217.1| hypothetical protein D910_12484 [Dendroctonus ponderosae] 752872390 XM_011255128.1 52 3.41081e-16 PREDICTED: Camponotus floridanus endocuticle structural glycoprotein SgAbd-1-like (LOC105249568), mRNA -- -- -- -- Q7M4F4 282 3.4e-24 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.51712 BP_3 468.86 4.48 5332 642918616 XP_008200343.1 2086 4.5e-231 PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum]>gi|642918618|ref|XP_008200351.1| PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum] 462322041 APGK01042995.1 78 1.0594e-29 Dendroctonus ponderosae Seq01043005, whole genome shotgun sequence -- -- -- -- Q61SK8 473 2.0e-45 MOG interacting and ectopic P-granules protein 1 OS=Caenorhabditis briggsae GN=mep-1 PE=3 SV=2 PF04692//PF13912//PF13465//PF00096 Platelet-derived growth factor, N terminal region//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0046872//GO:0008083 metal ion binding//growth factor activity GO:0016020 membrane -- -- Cluster-8309.51713 BP_3 907.83 8.85 5236 642918616 XP_008200343.1 2133 1.6e-236 PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum]>gi|642918618|ref|XP_008200351.1| PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum] 462322041 APGK01042995.1 78 1.0402e-29 Dendroctonus ponderosae Seq01043005, whole genome shotgun sequence -- -- -- -- Q21502 458 1.1e-43 MOG interacting and ectopic P-granules protein 1 OS=Caenorhabditis elegans GN=mep-1 PE=1 SV=2 PF13912//PF04692//PF00096//PF13465 C2H2-type zinc finger//Platelet-derived growth factor, N terminal region//Zinc finger, C2H2 type//Zinc-finger double domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083//GO:0046872 growth factor activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.51714 BP_3 209.14 1.19 8791 478255320 ENN75546.1 1154 8.8e-123 hypothetical protein YQE_07889, partial [Dendroctonus ponderosae] 462322041 APGK01042995.1 78 1.75059e-29 Dendroctonus ponderosae Seq01043005, whole genome shotgun sequence -- -- -- -- Q61SK8 296 1.1e-24 MOG interacting and ectopic P-granules protein 1 OS=Caenorhabditis briggsae GN=mep-1 PE=3 SV=2 PF00096//PF00253//PF04988//PF13465//PF04692//PF13912//PF15178//PF01530//PF05191//PF16622 Zinc finger, C2H2 type//Ribosomal protein S14p/S29e//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Platelet-derived growth factor, N terminal region//C2H2-type zinc finger//Mitochondrial import receptor subunit TOM5 homolog//Zinc finger, C2HC type//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0042254//GO:0006355//GO:0046034//GO:0007165//GO:0006144//GO:0006412//GO:0008283//GO:0040007 ribosome biogenesis//regulation of transcription, DNA-templated//ATP metabolic process//signal transduction//purine nucleobase metabolic process//translation//cell proliferation//growth GO:0003700//GO:0004017//GO:0003735//GO:0008270//GO:0046872//GO:0003677//GO:0008083 transcription factor activity, sequence-specific DNA binding//adenylate kinase activity//structural constituent of ribosome//zinc ion binding//metal ion binding//DNA binding//growth factor activity GO:0005742//GO:0005840//GO:0005622//GO:0016020//GO:0005667//GO:0005634 mitochondrial outer membrane translocase complex//ribosome//intracellular//membrane//transcription factor complex//nucleus -- -- Cluster-8309.51719 BP_3 107.09 1.90 3012 270013391 EFA09839.1 4485 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 366 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P31695 484 6.1e-47 Neurogenic locus notch homolog protein 4 OS=Mus musculus GN=Notch4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.51721 BP_3 484.03 7.24 3515 478255701 ENN75912.1 1275 3.3e-137 hypothetical protein YQE_07554, partial [Dendroctonus ponderosae] 817199099 XM_012419796.1 144 1.42354e-66 PREDICTED: Orussus abietinus transmembrane protein 189 (LOC105696934), transcript variant X3, mRNA K10704 UBE2V ubiquitin-conjugating enzyme E2 variant http://www.genome.jp/dbget-bin/www_bget?ko:K10704 A6QLM0 813 5.0e-85 Transmembrane protein 189 OS=Bos taurus GN=TMEM189 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0055114//GO:0006633 oxidation-reduction process//fatty acid biosynthetic process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- KOG3011 Ubiquitin-conjugating enzyme Cluster-8309.51722 BP_3 24.90 0.36 3639 91084025 XP_975362.1 1054 1.4e-111 PREDICTED: transmembrane protein 189 [Tribolium castaneum]>gi|270006701|gb|EFA03149.1| hypothetical protein TcasGA2_TC013062 [Tribolium castaneum] 817199099 XM_012419796.1 111 3.25971e-48 PREDICTED: Orussus abietinus transmembrane protein 189 (LOC105696934), transcript variant X3, mRNA K10704 UBE2V ubiquitin-conjugating enzyme E2 variant http://www.genome.jp/dbget-bin/www_bget?ko:K10704 A6QLM0 729 2.9e-75 Transmembrane protein 189 OS=Bos taurus GN=TMEM189 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- KOG3011 Ubiquitin-conjugating enzyme Cluster-8309.51723 BP_3 5.00 1.43 460 646723380 KDR24014.1 178 6.8e-11 hypothetical protein L798_07957, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51724 BP_3 65.75 0.54 6208 642918693 XP_008191540.1 2587 4.2e-289 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 1244 9.3e-135 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200//PF00788 Keratinocyte differentiation-associated//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.51729 BP_3 40.46 0.77 2813 642915596 XP_008190681.1 1038 7.9e-110 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B-B [Tribolium castaneum] -- -- -- -- -- K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 Q3TTA7 152 1.8e-08 E3 ubiquitin-protein ligase CBL-B OS=Mus musculus GN=Cblb PE=1 SV=3 PF02796 Helix-turn-helix domain of resolvase GO:0006310 DNA recombination GO:0000150//GO:0003677 recombinase activity//DNA binding -- -- -- -- Cluster-8309.5173 BP_3 2.00 0.41 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51730 BP_3 1199.41 10.10 6016 642915596 XP_008190681.1 2238 1.2e-248 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B-B [Tribolium castaneum] 801389704 XM_012201966.1 201 5.04071e-98 PREDICTED: Atta cephalotes E3 ubiquitin-protein ligase CBL-B (LOC105620476), transcript variant X3, mRNA K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 P22681 1636 3.2e-180 E3 ubiquitin-protein ligase CBL OS=Homo sapiens GN=CBL PE=1 SV=2 PF13639//PF02262//PF02761//PF00097//PF12678//PF14634//PF02796 Ring finger domain//CBL proto-oncogene N-terminal domain 1//CBL proto-oncogene N-terminus, EF hand-like domain//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain//Helix-turn-helix domain of resolvase GO:0006310//GO:0007166//GO:0007165 DNA recombination//cell surface receptor signaling pathway//signal transduction GO:0005509//GO:0008270//GO:0004871//GO:0046872//GO:0003677//GO:0000150//GO:0005515 calcium ion binding//zinc ion binding//signal transducer activity//metal ion binding//DNA binding//recombinase activity//protein binding GO:0005634 nucleus KOG1785 Tyrosine kinase negative regulator CBL Cluster-8309.51731 BP_3 35.61 0.76 2538 478253028 ENN73408.1 1589 9.2e-174 hypothetical protein YQE_09970, partial [Dendroctonus ponderosae] 801389704 XM_012201966.1 126 1.0391e-56 PREDICTED: Atta cephalotes E3 ubiquitin-protein ligase CBL-B (LOC105620476), transcript variant X3, mRNA K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 Q13191 1160 2.1e-125 E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens GN=CBLB PE=1 SV=2 PF02262//PF02761 CBL proto-oncogene N-terminal domain 1//CBL proto-oncogene N-terminus, EF hand-like domain GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0004871//GO:0005509 signal transducer activity//calcium ion binding GO:0005634 nucleus KOG1785 Tyrosine kinase negative regulator CBL Cluster-8309.51733 BP_3 28.65 0.46 3301 91079957 XP_969398.1 635 5.0e-63 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6L5 146 1.0e-07 Cyclic GMP-AMP synthase OS=Mus musculus GN=Mb21d1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51736 BP_3 143.33 0.62 11347 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 1.2e-260 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF00856//PF01344//PF07646//PF00651 SET domain//Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.51741 BP_3 4.00 0.37 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51743 BP_3 9.54 0.34 1662 270008586 EFA05034.1 523 2.4e-50 hypothetical protein TcasGA2_TC015122 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZP9 335 6.3e-30 GAS2-like protein 1 OS=Mus musculus GN=Gas2l1 PE=2 SV=1 PF02187 Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest -- -- -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.51746 BP_3 42.54 0.78 2930 642933293 XP_968154.2 806 6.6e-83 PREDICTED: putative ribosomal RNA methyltransferase CG11447 [Tribolium castaneum] -- -- -- -- -- K02427 rlmE, rrmJ, ftsJ 23S rRNA (uridine2552-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K02427 Q9VDT6 673 7.2e-69 rRNA methyltransferase 2, mitochondrial OS=Drosophila melanogaster GN=CG11447 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ Cluster-8309.51747 BP_3 5.00 0.33 1016 91077308 XP_968724.1 881 4.6e-92 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001657|gb|EEZ98104.1| hypothetical protein TcasGA2_TC000517 [Tribolium castaneum] 762079884 XM_011415836.1 35 1.57422e-06 PREDICTED: Crassostrea gigas thaumatin-like protein 1b (LOC105318618), mRNA -- -- -- -- P28493 572 1.3e-57 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51749 BP_3 27.10 1.48 1176 91083575 XP_968060.1 455 1.3e-42 PREDICTED: ribonuclease H2 subunit B [Tribolium castaneum]>gi|270007823|gb|EFA04271.1| hypothetical protein TcasGA2_TC014561 [Tribolium castaneum] -- -- -- -- -- K10744 RNASEH2B ribonuclease H2 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10744 Q5HZP1 148 2.2e-08 Ribonuclease H2 subunit B OS=Xenopus laevis GN=rnaseh2b PE=2 SV=1 PF09468 Ydr279p protein family (RNase H2 complex component) -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.51751 BP_3 30.31 0.97 1792 607362518 EZA56769.1 1781 3.5e-196 hypothetical protein X777_03234 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.51752 BP_3 5.00 3.60 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51755 BP_3 7.00 0.48 990 645040646 XP_008210807.1 316 1.5e-26 PREDICTED: uncharacterized protein LOC100117040 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51757 BP_3 95.48 0.47 10076 759070124 XP_011344632.1 3031 0.0e+00 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51759 BP_3 110.24 0.54 10063 759070124 XP_011344632.1 3059 0.0e+00 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06616 BsuBI/PstI restriction endonuclease C-terminus GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0000287//GO:0009036//GO:0003677 magnesium ion binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.51760 BP_3 4.00 1.79 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51761 BP_3 47.29 0.32 7462 759070124 XP_011344632.1 2199 5.0e-244 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06616 BsuBI/PstI restriction endonuclease C-terminus GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036//GO:0000287 DNA binding//Type II site-specific deoxyribonuclease activity//magnesium ion binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.51764 BP_3 16.23 0.60 1594 546670638 ERL83322.1 416 6.0e-38 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51765 BP_3 88.81 0.42 10437 642935083 XP_008197877.1 2530 2.9e-282 PREDICTED: calmodulin-binding transcription activator 2-like isoform X3 [Tribolium castaneum] 642935084 XM_008199656.1 481 0 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- Q9Y6Y1 651 9.1e-66 Calmodulin-binding transcription activator 1 OS=Homo sapiens GN=CAMTA1 PE=1 SV=4 PF03859//PF13606//PF01833//PF00023//PF00612//PF10371//PF00899 CG-1 domain//Ankyrin repeat//IPT/TIG domain//Ankyrin repeat//IQ calmodulin-binding motif//Domain of unknown function//ThiF family GO:0055114 oxidation-reduction process GO:0003677//GO:0016903//GO:0005515//GO:0008641 DNA binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors//protein binding//small protein activating enzyme activity GO:0005634 nucleus KOG0520 Uncharacterized conserved protein, contains IPT/TIG domain Cluster-8309.51766 BP_3 187.31 3.45 2910 270004664 EFA01112.1 1792 3.0e-197 hypothetical protein TcasGA2_TC010324 [Tribolium castaneum] 752889233 XM_011264255.1 203 1.87276e-99 PREDICTED: Camponotus floridanus probable ATP-dependent RNA helicase DDX17 (LOC105255133), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q92841 1426 3.4e-156 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 PF00270//PF00004//PF04851 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.51767 BP_3 353.76 5.31 3504 91094511 XP_971832.1 1240 3.7e-133 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.54863e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 O35737 863 8.0e-91 Heterogeneous nuclear ribonucleoprotein H OS=Mus musculus GN=Hnrnph1 PE=1 SV=3 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0097159//GO:1901363//GO:0003676 RNA binding//organic cyclic compound binding//heterocyclic compound binding//nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.51769 BP_3 233.00 3.62 3390 224994808 NP_001139341.1 1845 2.5e-203 apterous a [Tribolium castaneum]>gi|224459212|gb|ACN43341.1| apterous a [Tribolium castaneum] 224994807 NM_001145869.1 548 0 Tribolium castaneum apterous a (LOC658656), mRNA >gnl|BL_ORD_ID|6468650 Tribolium castaneum apterous a (ap A) mRNA, complete cds K09373 LHX2_9 LIM homeobox protein 2/9 http://www.genome.jp/dbget-bin/www_bget?ko:K09373 P36198 746 2.8e-77 LIM/homeobox protein Lhx2 OS=Rattus norvegicus GN=Lhx2 PE=2 SV=1 PF00046//PF13417//PF05920//PF00412//PF08407 Homeobox domain//Glutathione S-transferase, N-terminal domain//Homeobox KN domain//LIM domain//Chitin synthase N-terminal GO:0006031//GO:0006355 chitin biosynthetic process//regulation of transcription, DNA-templated GO:0005515//GO:0004100//GO:0003677//GO:0046872//GO:0003700//GO:0008270//GO:0043565 protein binding//chitin synthase activity//DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0490 Transcription factor, contains HOX domain Cluster-8309.5177 BP_3 1.00 0.40 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51770 BP_3 101.92 0.90 5730 642937199 XP_008198736.1 4828 0.0e+00 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 5.33696e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1968 9.6e-219 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00454//PF00168//PF00787 Phosphatidylinositol 3- and 4-kinase//C2 domain//PX domain -- -- GO:0005515//GO:0035091//GO:0016773 protein binding//phosphatidylinositol binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.51771 BP_3 387.78 11.08 1979 642122061 CDQ63792.1 197 1.8e-12 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14372//PF02083 Domain of unknown function (DUF4413)//Urotensin II GO:0007165//GO:0042312//GO:0008217 signal transduction//regulation of vasodilation//regulation of blood pressure GO:0003677//GO:0005179 DNA binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.51772 BP_3 575.44 4.94 5910 642937199 XP_008198736.1 4828 0.0e+00 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 5.50568e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1968 9.9e-219 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00168//PF00787//PF00454 C2 domain//PX domain//Phosphatidylinositol 3- and 4-kinase -- -- GO:0016773//GO:0035091//GO:0005515 phosphotransferase activity, alcohol group as acceptor//phosphatidylinositol binding//protein binding -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.51775 BP_3 29.14 2.78 796 478252357 ENN72783.1 452 2.0e-42 hypothetical protein YQE_10588, partial [Dendroctonus ponderosae]>gi|546680689|gb|ERL90915.1| hypothetical protein D910_08259 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A4QNC6 233 2.0e-18 Protein FAM136A OS=Xenopus tropicalis GN=fam136a PE=2 SV=1 PF02970//PF07464//PF00174 Tubulin binding cofactor A//Apolipophorin-III precursor (apoLp-III)//Oxidoreductase molybdopterin binding domain GO:0007021//GO:0006869//GO:0042128 tubulin complex assembly//lipid transport//nitrate assimilation GO:0051082//GO:0015631//GO:0008289 unfolded protein binding//tubulin binding//lipid binding GO:0005576//GO:0045298 extracellular region//tubulin complex KOG3377 Uncharacterized conserved protein Cluster-8309.51776 BP_3 859.17 7.77 5621 642912926 XP_008201309.1 1747 9.7e-192 PREDICTED: LOW QUALITY PROTEIN: RNA polymerase II-associated factor 1 homolog [Tribolium castaneum] 808145633 XM_012318648.1 294 9.42754e-150 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K15174 PAF1 RNA polymerase II-associated factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15174 B3A0N5 1263 5.3e-137 Apyrase OS=Tabanus yao PE=1 SV=1 PF03985//PF00149//PF01757//PF02872 Paf1//Calcineurin-like phosphoesterase//Acyltransferase family//5'-nucleotidase, C-terminal domain GO:0009166//GO:0016570//GO:0006368 nucleotide catabolic process//histone modification//transcription elongation from RNA polymerase II promoter GO:0016787//GO:0016747 hydrolase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016593 Cdc73/Paf1 complex KOG2478 Putative RNA polymerase II regulator Cluster-8309.51777 BP_3 53.63 0.44 6135 642912926 XP_008201309.1 1747 1.1e-191 PREDICTED: LOW QUALITY PROTEIN: RNA polymerase II-associated factor 1 homolog [Tribolium castaneum] 808145633 XM_012318648.1 294 1.02952e-149 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K15174 PAF1 RNA polymerase II-associated factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15174 B3A0N5 1282 3.6e-139 Apyrase OS=Tabanus yao PE=1 SV=1 PF01757//PF02872//PF00149//PF03985 Acyltransferase family//5'-nucleotidase, C-terminal domain//Calcineurin-like phosphoesterase//Paf1 GO:0009166//GO:0016570//GO:0006368 nucleotide catabolic process//histone modification//transcription elongation from RNA polymerase II promoter GO:0016787//GO:0016747 hydrolase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016593 Cdc73/Paf1 complex KOG2478 Putative RNA polymerase II regulator Cluster-8309.51779 BP_3 102.83 1.40 3821 641654576 XP_008179259.1 844 3.4e-87 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A2T812 773 2.4e-80 Zinc finger protein 287 OS=Pongo pygmaeus GN=ZNF287 PE=3 SV=1 PF07975//PF00096//PF13465//PF16622//PF13912 TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.51781 BP_3 5.00 0.44 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51783 BP_3 5.57 1.25 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51785 BP_3 37.36 0.39 4884 478254712 ENN74953.1 1284 4.1e-138 hypothetical protein YQE_08530, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 1247 3.3e-135 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF15886//PF00722 Carbohydrate binding domain (family 32)//Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0030246 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding -- -- -- -- Cluster-8309.51787 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51788 BP_3 10.14 0.96 800 572270616 XP_006613297.1 380 4.5e-34 PREDICTED: RNA-binding protein 1-like isoform X4 [Apis dorsata] 752865554 XM_011270924.1 75 7.13355e-29 PREDICTED: Camponotus floridanus RNA-binding protein 1-like (LOC105259161), transcript variant X11, mRNA K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q02427 343 3.6e-31 RNA-binding protein 1 OS=Drosophila melanogaster GN=Rbp1 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily) Cluster-8309.51791 BP_3 60.92 1.31 2532 642918927 XP_008191660.1 172 1.9e-09 PREDICTED: uncharacterized protein LOC662701 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01873//PF03298 Domain found in IF2B/IF5//Stanniocalcin family GO:0006413//GO:0007165//GO:0006446 translational initiation//signal transduction//regulation of translational initiation GO:0003743//GO:0005179 translation initiation factor activity//hormone activity GO:0005576//GO:0005840 extracellular region//ribosome -- -- Cluster-8309.51792 BP_3 325.54 1.86 8738 642938393 XP_008191052.1 2835 0.0e+00 PREDICTED: serine-protein kinase ATM isoform X2 [Tribolium castaneum] -- -- -- -- -- K04728 ATM, TEL1 ataxia telangiectasia mutated family protein http://www.genome.jp/dbget-bin/www_bget?ko:K04728 Q6PQD5 1670 5.3e-184 Serine-protein kinase ATM OS=Sus scrofa GN=ATM PE=3 SV=2 PF03868//PF02259//PF11640//PF02985//PF02260//PF00071//PF00454 Ribosomal protein L6, N-terminal domain//FAT domain//Telomere-length maintenance and DNA damage repair//HEAT repeat//FATC domain//Ras family//Phosphatidylinositol 3- and 4-kinase GO:0007264//GO:0042254//GO:0009069//GO:0006412//GO:0016310 small GTPase mediated signal transduction//ribosome biogenesis//serine family amino acid metabolic process//translation//phosphorylation GO:0003735//GO:0016773//GO:0005525//GO:0004674//GO:0005515 structural constituent of ribosome//phosphotransferase activity, alcohol group as acceptor//GTP binding//protein serine/threonine kinase activity//protein binding GO:0005840//GO:0005622 ribosome//intracellular KOG0892 Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair Cluster-8309.51793 BP_3 127.73 0.73 8735 642938393 XP_008191052.1 3267 0.0e+00 PREDICTED: serine-protein kinase ATM isoform X2 [Tribolium castaneum] -- -- -- -- -- K04728 ATM, TEL1 ataxia telangiectasia mutated family protein http://www.genome.jp/dbget-bin/www_bget?ko:K04728 Q6PQD5 1815 8.1e-201 Serine-protein kinase ATM OS=Sus scrofa GN=ATM PE=3 SV=2 PF02259//PF11640//PF00454//PF00071//PF02260 FAT domain//Telomere-length maintenance and DNA damage repair//Phosphatidylinositol 3- and 4-kinase//Ras family//FATC domain GO:0016310//GO:0009069//GO:0007264 phosphorylation//serine family amino acid metabolic process//small GTPase mediated signal transduction GO:0005525//GO:0016773//GO:0004674//GO:0005515 GTP binding//phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein binding -- -- KOG0892 Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair Cluster-8309.51794 BP_3 5.88 0.33 1154 91083895 XP_974479.1 442 4.2e-41 PREDICTED: ATPase family AAA domain-containing protein 3 [Tribolium castaneum]>gi|270007948|gb|EFA04396.1| hypothetical protein TcasGA2_TC014695 [Tribolium castaneum] -- -- -- -- -- K17681 ATAD3A_B ATPase family AAA domain-containing protein 3A/B http://www.genome.jp/dbget-bin/www_bget?ko:K17681 Q3KRE0 305 1.3e-26 ATPase family AAA domain-containing protein 3 OS=Rattus norvegicus GN=Atad3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0742 AAA+-type ATPase Cluster-8309.51795 BP_3 47.30 0.49 4953 642919536 XP_008191915.1 146 3.8e-06 PREDICTED: uncharacterized protein LOC103312626 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51796 BP_3 73.26 5.49 935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51797 BP_3 167.02 1.68 5097 642929205 XP_008195735.1 3747 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 694 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q920I9 1610 2.8e-177 WD repeat-containing protein 7 OS=Mus musculus GN=Wdr7 PE=1 SV=3 PF00784//PF00400//PF01506 MyTH4 domain//WD domain, G-beta repeat//Hepatitis C virus non-structural 5a protein membrane anchor GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0004197//GO:0004252//GO:0017111//GO:0003968//GO:0005515 cysteine-type endopeptidase activity//serine-type endopeptidase activity//nucleoside-triphosphatase activity//RNA-directed RNA polymerase activity//protein binding GO:0031379//GO:0005856 RNA-directed RNA polymerase complex//cytoskeleton KOG4155 FOG: WD40 repeat Cluster-8309.51799 BP_3 667.01 4.31 7758 270001259 EEZ97706.1 4646 0.0e+00 brahma [Tribolium castaneum] 801398653 XM_012204404.1 479 0 PREDICTED: Atta cephalotes ATP-dependent helicase brm (LOC105623001), mRNA K11647 SMARCA2_4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K11647 P25439 3883 0.0e+00 ATP-dependent helicase brm OS=Drosophila melanogaster GN=brm PE=1 SV=2 PF00439//PF08880//PF07533//PF14619//PF00270//PF02935//PF13892//PF00176//PF04851 Bromodomain//QLQ//BRK domain//Snf2-ATP coupling, chromatin remodelling complex//DEAD/DEAH box helicase//Cytochrome c oxidase subunit VIIc//DNA-binding domain//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0015992//GO:0006355//GO:0006123 proton transport//regulation of transcription, DNA-templated//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0016817//GO:0042393//GO:0003676//GO:0005515//GO:0005524//GO:0003677//GO:0016787 cytochrome-c oxidase activity//hydrolase activity, acting on acid anhydrides//histone binding//nucleic acid binding//protein binding//ATP binding//DNA binding//hydrolase activity GO:0045277//GO:0005634 respiratory chain complex IV//nucleus KOG0386 Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) Cluster-8309.518 BP_3 7.00 0.63 829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5180 BP_3 6.00 1.57 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51801 BP_3 116.88 3.82 1766 478257549 ENN77703.1 413 1.5e-37 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 153 8.6e-09 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.51802 BP_3 83.63 1.72 2634 642926449 XP_008191964.1 1143 5.0e-122 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|642926451|ref|XP_008191965.1| PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009087|gb|EFA05535.1| hypothetical protein TcasGA2_TC015722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 538 2.9e-53 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF13495//PF00732 GMC oxidoreductase//Phage integrase, N-terminal SAM-like domain//GMC oxidoreductase GO:0015074//GO:0055114 DNA integration//oxidation-reduction process GO:0003677//GO:0050660//GO:0016614 DNA binding//flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.51803 BP_3 3.16 0.59 549 642934179 XP_008199640.1 750 3.8e-77 PREDICTED: uncharacterized protein LOC657682 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZMT1 173 1.3e-11 SH3 and cysteine-rich domain-containing protein 2 OS=Homo sapiens GN=STAC2 PE=1 SV=1 PF00130//PF07649//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain//PHD-finger GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0047134//GO:0005515 protein-disulfide reductase activity//protein binding -- -- -- -- Cluster-8309.51807 BP_3 945.21 17.73 2861 642931092 XP_008196207.1 2570 1.8e-287 PREDICTED: ATP-dependent RNA helicase DDX42 [Tribolium castaneum]>gi|270012072|gb|EFA08520.1| hypothetical protein TcasGA2_TC006173 [Tribolium castaneum] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q5F485 1661 1.9e-183 ATP-dependent RNA helicase DDX42 OS=Gallus gallus GN=DDX42 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524//GO:0008026 nucleic acid binding//hydrolase activity//DNA binding//ATP binding//ATP-dependent helicase activity -- -- KOG0334 RNA helicase Cluster-8309.51808 BP_3 25.52 0.47 2919 642931092 XP_008196207.1 2405 2.5e-268 PREDICTED: ATP-dependent RNA helicase DDX42 [Tribolium castaneum]>gi|270012072|gb|EFA08520.1| hypothetical protein TcasGA2_TC006173 [Tribolium castaneum] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q5F485 1676 3.5e-185 ATP-dependent RNA helicase DDX42 OS=Gallus gallus GN=DDX42 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0008026//GO:0005524//GO:0003676//GO:0003677//GO:0016787 ATP-dependent helicase activity//ATP binding//nucleic acid binding//DNA binding//hydrolase activity -- -- KOG0334 RNA helicase Cluster-8309.5181 BP_3 5.00 0.85 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51812 BP_3 20.00 0.43 2534 189241889 XP_968786.2 2194 6.4e-244 PREDICTED: glutamate receptor 1 [Tribolium castaneum]>gi|270016489|gb|EFA12935.1| hypothetical protein TcasGA2_TC010481 [Tribolium castaneum] 884951073 XM_010899911.2 47 8.54715e-13 PREDICTED: Esox lucius glutamate receptor, ionotropic, AMPA 2 (gria2), transcript variant X7, mRNA K05200 GRIA4 glutamate receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05200 Q03445 1509 7.1e-166 Glutamate receptor 1 OS=Drosophila melanogaster GN=GluRIA PE=2 SV=2 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0035235//GO:0006811 signal transduction//synaptic transmission//ionotropic glutamate receptor signaling pathway//ion transport GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0030288//GO:0005886//GO:0016021//GO:0016020//GO:0030054//GO:0045211 outer membrane-bounded periplasmic space//plasma membrane//integral component of membrane//membrane//cell junction//postsynaptic membrane KOG1054 Glutamate-gated AMPA-type ion channel receptor subunit GluR2 and related subunits Cluster-8309.51814 BP_3 294.28 4.96 3152 642937952 XP_970081.3 435 7.4e-40 PREDICTED: uncharacterized protein LOC658612 isoform X2 [Tribolium castaneum]>gi|270015689|gb|EFA12137.1| hypothetical protein TcasGA2_TC002283 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51816 BP_3 13.00 1.35 755 752871781 XP_011253103.1 673 4.5e-68 PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus]>gi|752871783|ref|XP_011253104.1| PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus] 826438850 XM_012674433.1 127 8.32476e-58 PREDICTED: Monomorium pharaonis uncharacterized LOC105833032 (LOC105833032), mRNA -- -- -- -- Q3ZCU0 217 1.4e-16 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.51817 BP_3 11.00 0.58 1208 795021508 XP_011860288.1 891 3.8e-93 PREDICTED: putative uncharacterized protein FLJ37770 [Vollenhovia emeryi] 752884322 XM_011261597.1 329 6.92495e-170 PREDICTED: Camponotus floridanus putative uncharacterized protein FLJ37770 (LOC105253516), mRNA -- -- -- -- Q3ZCU0 249 4.3e-20 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 PF12844//PF00665 Helix-turn-helix domain//Integrase core domain GO:0015074 DNA integration GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.51818 BP_3 7.00 0.57 880 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51821 BP_3 17.09 0.55 1785 546685752 ERL95207.1 1000 1.3e-105 hypothetical protein D910_12474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XIJ8 413 6.1e-39 Coiled-coil domain-containing protein 65 OS=Rattus norvegicus GN=Ccdc65 PE=2 SV=1 PF02927 N-terminal ig-like domain of cellulase GO:0005982//GO:0005985//GO:0005975 starch metabolic process//sucrose metabolic process//carbohydrate metabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-8309.51825 BP_3 11.00 0.70 1052 817089178 XP_012267440.1 531 1.8e-51 PREDICTED: PDZ and LIM domain protein Zasp isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- A1ZA47 493 1.9e-48 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.51826 BP_3 99.39 0.95 5352 270002209 EEZ98656.1 1922 4.7e-212 hypothetical protein TcasGA2_TC001185 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1123 8.6e-121 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.51830 BP_3 439.34 5.35 4251 642932427 XP_008197107.1 4443 0.0e+00 PREDICTED: uncharacterized protein KIAA0195 isoform X2 [Tribolium castaneum]>gi|270012352|gb|EFA08800.1| hypothetical protein TcasGA2_TC006494 [Tribolium castaneum] 391330831 XM_003739808.1 45 1.86428e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 1284 1.5e-139 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF01844//PF08053//PF00122 HNH endonuclease//Tryptophanase operon leader peptide//E1-E2 ATPase GO:0031554//GO:0031556 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome GO:0046872//GO:0000166//GO:0004519//GO:0003676 metal ion binding//nucleotide binding//endonuclease activity//nucleic acid binding -- -- KOG4383 Uncharacterized conserved protein Cluster-8309.51832 BP_3 151.09 1.68 4637 478261315 ENN80731.1 2577 4.6e-288 hypothetical protein YQE_02839, partial [Dendroctonus ponderosae] 391330831 XM_003739808.1 45 2.035e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q7TSH8 909 4.9e-96 Uncharacterized protein KIAA0195 OS=Mus musculus GN=Kiaa0195 PE=2 SV=1 PF01844//PF00122 HNH endonuclease//E1-E2 ATPase -- -- GO:0003676//GO:0000166//GO:0004519//GO:0046872 nucleic acid binding//nucleotide binding//endonuclease activity//metal ion binding -- -- KOG4383 Uncharacterized conserved protein Cluster-8309.51838 BP_3 127.81 4.04 1817 91092536 XP_967769.1 1936 3.8e-214 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 441 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1235 3.0e-134 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.51844 BP_3 16.40 0.39 2332 642940163 XP_972562.2 2109 4.2e-234 PREDICTED: integral membrane protein GPR155 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R9A7 897 6.0e-95 Integral membrane protein GPR155 OS=Pongo abelii GN=GPR155 PE=2 SV=1 PF03547 Membrane transport protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51846 BP_3 570.92 7.05 4194 642940163 XP_972562.2 2969 0.0e+00 PREDICTED: integral membrane protein GPR155 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R9A7 897 1.1e-94 Integral membrane protein GPR155 OS=Pongo abelii GN=GPR155 PE=2 SV=1 PF03547//PF00610 Membrane transport protein//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556//GO:0055085 intracellular signal transduction//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51847 BP_3 1756.67 13.01 6801 546675629 ERL86779.1 7377 0.0e+00 hypothetical protein D910_04185 [Dendroctonus ponderosae] 705688754 XM_010123154.1 36 3.01198e-06 PREDICTED: Chlamydotis macqueenii activating signal cointegrator 1 complex subunit 3 (ASCC3), partial mRNA K18663 ASCC3 activating signal cointegrator complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18663 F1NTD6 3950 0.0e+00 Activating signal cointegrator 1 complex subunit 3 OS=Gallus gallus GN=ascc3 PE=3 SV=2 PF00270//PF00437//PF02562//PF04851//PF00098//PF00580//PF00176 DEAD/DEAH box helicase//Type II/IV secretion system protein//PhoH-like protein//Type III restriction enzyme, res subunit//Zinc knuckle//UvrD/REP helicase N-terminal domain//SNF2 family N-terminal domain GO:0006810 transport GO:0003676//GO:0003677//GO:0016787//GO:0005524//GO:0008270 nucleic acid binding//DNA binding//hydrolase activity//ATP binding//zinc ion binding -- -- KOG0952 DNA/RNA helicase MER3/SLH1, DEAD-box superfamily Cluster-8309.51848 BP_3 76.93 1.38 2974 642938535 XP_008199831.1 737 6.7e-75 PREDICTED: uncharacterized protein LOC103314771 [Tribolium castaneum] 642938534 XM_008201609.1 67 7.65652e-24 PREDICTED: Tribolium castaneum uncharacterized LOC103314771 (LOC103314771), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51851 BP_3 741.76 8.54 4477 642926793 XP_008195018.1 4231 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 87 8.82108e-35 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2521 5.6e-283 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF00651//PF00023//PF01363//PF13606//PF01155//PF01068 BTB/POZ domain//Ankyrin repeat//FYVE zinc finger//Ankyrin repeat//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//ATP dependent DNA ligase domain GO:0006260//GO:0006310//GO:0006281//GO:0006464 DNA replication//DNA recombination//DNA repair//cellular protein modification process GO:0046872//GO:0003910//GO:0005515//GO:0016151//GO:0005524 metal ion binding//DNA ligase (ATP) activity//protein binding//nickel cation binding//ATP binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.51854 BP_3 5.96 0.32 1189 642919915 XP_008192123.1 1014 2.0e-107 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9K8 222 5.8e-17 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0507 CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain Cluster-8309.51858 BP_3 483.34 1.55 15365 642914247 XP_008201606.1 18780 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10506 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF00028//PF07645//PF00008 Cadherin domain//Calcium-binding EGF domain//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.51862 BP_3 38.09 1.53 1491 805813989 XP_012148087.1 393 2.6e-35 PREDICTED: glucocorticoid-induced transcript 1 protein-like isoform X1 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q6P1L5 239 7.7e-19 Protein FAM117B OS=Homo sapiens GN=FAM117B PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51863 BP_3 15.34 0.36 2324 755974462 XP_011307335.1 391 6.9e-35 PREDICTED: protein FAM117B-like isoform X1 [Fopius arisanus]>gi|755974465|ref|XP_011307336.1| PREDICTED: protein FAM117B-like isoform X1 [Fopius arisanus]>gi|755974469|ref|XP_011307337.1| PREDICTED: protein FAM117B-like isoform X1 [Fopius arisanus] -- -- -- -- -- -- -- -- -- Q6P1L5 239 1.2e-18 Protein FAM117B OS=Homo sapiens GN=FAM117B PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51867 BP_3 4.00 1.36 433 307190171 EFN74294.1 232 3.5e-17 120.7 kDa protein in NOF-FB transposable element, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51868 BP_3 58.82 1.23 2597 307186237 EFN71909.1 331 7.0e-28 120.7 kDa protein in NOF-FB transposable element [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17078 SWI5-dependent HO expression protein 3 GO:0048309//GO:0051028 endoplasmic reticulum inheritance//mRNA transport -- -- -- -- -- -- Cluster-8309.51869 BP_3 3.21 0.40 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51872 BP_3 381.51 3.23 5983 642920211 XP_008192250.1 2586 5.3e-289 PREDICTED: LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11 [Tribolium castaneum] 721631354 XM_003567893.2 45 2.63033e-11 PREDICTED: Brachypodium distachyon mannose-6-phosphate isomerase 1 (LOC100835530), mRNA K11273 DDX11, CHL1, CTF1 chromosome transmission fidelity protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11273 Q92771 1452 6.8e-159 Putative ATP-dependent RNA helicase DDX12 OS=Homo sapiens GN=DDX12P PE=5 SV=3 PF00170//PF13307//PF01238//PF02944//PF06733//PF08471//PF04851//PF02562//PF01416 bZIP transcription factor//Helicase C-terminal domain//Phosphomannose isomerase type I//BESS motif//DEAD_2//Class II vitamin B12-dependent ribonucleotide reductase//Type III restriction enzyme, res subunit//PhoH-like protein//tRNA pseudouridine synthase GO:0006000//GO:0005975//GO:0001522//GO:0055114//GO:0006355//GO:0006139//GO:0006013//GO:0009451//GO:0006206//GO:0006144//GO:0009186 fructose metabolic process//carbohydrate metabolic process//pseudouridine synthesis//oxidation-reduction process//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process//mannose metabolic process//RNA modification//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process GO:0016818//GO:0050897//GO:0003700//GO:0004003//GO:0009982//GO:0043565//GO:0008270//GO:0004476//GO:0016787//GO:0005524//GO:0003676//GO:0004748//GO:0008026//GO:0003677//GO:0003723 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//cobalt ion binding//transcription factor activity, sequence-specific DNA binding//ATP-dependent DNA helicase activity//pseudouridine synthase activity//sequence-specific DNA binding//zinc ion binding//mannose-6-phosphate isomerase activity//hydrolase activity//ATP binding//nucleic acid binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//ATP-dependent helicase activity//DNA binding//RNA binding GO:0005971//GO:0005667//GO:0005657 ribonucleoside-diphosphate reductase complex//transcription factor complex//replication fork KOG1133 Helicase of the DEAD superfamily Cluster-8309.51873 BP_3 222.00 2.34 4871 478253139 ENN73510.1 1950 2.4e-215 hypothetical protein YQE_09761, partial [Dendroctonus ponderosae]>gi|546678891|gb|ERL89429.1| hypothetical protein D910_06796 [Dendroctonus ponderosae] -- -- -- -- -- K16309 MASTL, GW serine/threonine-protein kinase greatwall http://www.genome.jp/dbget-bin/www_bget?ko:K16309 Q9VM60 1077 1.7e-115 Mini-chromosome maintenance complex-binding protein OS=Drosophila melanogaster GN=CG3430 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG2545 Conserved membrane protein Cluster-8309.51878 BP_3 69.23 0.69 5130 642935997 XP_008198262.1 1304 2.1e-140 PREDICTED: ileal sodium/bile acid cotransporter isoform X2 [Tribolium castaneum] -- -- -- -- -- K14343 SLC10A3_5 solute carrier family 10 (sodium/bile acid cotransporter), member 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14343 P09131 356 7.2e-32 P3 protein OS=Homo sapiens GN=SLC10A3 PE=2 SV=1 PF04785//PF01758 Rhabdovirus matrix protein M2//Sodium Bile acid symporter family GO:0016032 viral process -- -- GO:0016020//GO:0019031 membrane//viral envelope KOG2718 Na+-bile acid cotransporter Cluster-8309.51885 BP_3 1228.37 16.21 3945 642912351 XP_008199606.1 871 2.6e-90 PREDICTED: formin-binding protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQ03 139 8.0e-07 Formin-binding protein 4 OS=Mus musculus GN=Fnbp4 PE=1 SV=2 PF00397//PF06632 WW domain//DNA double-strand break repair and V(D)J recombination protein XRCC4 GO:0006302//GO:0006310 double-strand break repair//DNA recombination GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.51886 BP_3 457.19 5.64 4200 270002668 EEZ99115.1 599 9.5e-59 hypothetical protein TcasGA2_TC005008 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQ03 139 8.6e-07 Formin-binding protein 4 OS=Mus musculus GN=Fnbp4 PE=1 SV=2 PF00397//PF07267//PF00963 WW domain//Nucleopolyhedrovirus capsid protein P87//Cohesin domain GO:0000272 polysaccharide catabolic process GO:0030246//GO:0005515 carbohydrate binding//protein binding GO:0019028 viral capsid -- -- Cluster-8309.51887 BP_3 605.43 7.76 4053 642912351 XP_008199606.1 871 2.6e-90 PREDICTED: formin-binding protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQ03 139 8.3e-07 Formin-binding protein 4 OS=Mus musculus GN=Fnbp4 PE=1 SV=2 PF00397//PF01213//PF06632 WW domain//Adenylate cyclase associated (CAP) N terminal//DNA double-strand break repair and V(D)J recombination protein XRCC4 GO:0007010//GO:0006302//GO:0006310 cytoskeleton organization//double-strand break repair//DNA recombination GO:0003779//GO:0005515//GO:0003677 actin binding//protein binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.51888 BP_3 28.93 1.43 1264 642912701 XP_970424.2 791 1.6e-81 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q7XJS0 279 1.5e-23 Histone-lysine N-methyltransferase ASHR1 OS=Arabidopsis thaliana GN=ASHR1 PE=2 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.51892 BP_3 481.19 20.30 1434 91091890 XP_970295.1 1595 1.0e-174 PREDICTED: mitotic checkpoint protein BUB3 [Tribolium castaneum]>gi|270001257|gb|EEZ97704.1| budding uninhibited by benzimidazoles 3 [Tribolium castaneum] 642937433 XM_965202.2 331 6.38473e-171 PREDICTED: Tribolium castaneum budding uninhibited by benzimidazoles 3 (LOC658849), mRNA K02180 BUB3 cell cycle arrest protein BUB3 http://www.genome.jp/dbget-bin/www_bget?ko:K02180 Q1JQB2 1172 4.8e-127 Mitotic checkpoint protein BUB3 OS=Bos taurus GN=BUB3 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily Cluster-8309.51893 BP_3 31.13 0.97 1835 270000732 EEZ97179.1 795 7.8e-82 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] -- -- -- -- -- K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q5REX3 466 4.5e-45 Zinc finger RNA-binding protein OS=Pongo abelii GN=ZFR PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.51898 BP_3 13.00 2.71 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51900 BP_3 18.50 0.58 1827 741829513 AJA91072.1 1636 2.3e-179 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 1092 1.2e-117 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.51901 BP_3 2769.42 39.37 3682 189235428 XP_001812612.1 4557 0.0e+00 PREDICTED: importin-4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEX9 1523 2.5e-167 Importin-4 OS=Homo sapiens GN=IPO4 PE=1 SV=2 PF03810//PF02985//PF07836//PF00514 Importin-beta N-terminal domain//HEAT repeat//DmpG-like communication domain//Armadillo/beta-catenin-like repeat GO:0019439//GO:0006886 aromatic compound catabolic process//intracellular protein transport GO:0005515//GO:0016833//GO:0008536 protein binding//oxo-acid-lyase activity//Ran GTPase binding -- -- KOG2171 Karyopherin (importin) beta 3 Cluster-8309.51902 BP_3 295.83 1.58 9314 270006108 EFA02556.1 1457 6.8e-158 hypothetical protein TcasGA2_TC008263 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 436 6.9e-41 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 PF08916 Phenylalanine zipper GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0004871 signal transducer activity -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.51903 BP_3 171.00 3.44 2685 91083987 XP_975212.1 1084 3.5e-115 PREDICTED: protein asteroid [Tribolium castaneum]>gi|270007987|gb|EFA04435.1| hypothetical protein TcasGA2_TC014736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VPW1 478 2.7e-46 Protein asteroid OS=Drosophila melanogaster GN=ast PE=2 SV=1 PF00752 XPG N-terminal domain GO:0006281//GO:0090304 DNA repair//nucleic acid metabolic process GO:0004518 nuclease activity -- -- -- -- Cluster-8309.51905 BP_3 188.31 1.62 5904 641682104 XP_008189718.1 666 2.3e-66 PREDICTED: uncharacterized protein LOC100570869 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q96DM1 150 6.4e-08 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF02609 Exonuclease VII small subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.51906 BP_3 73.57 0.98 3899 546680539 ERL90799.1 938 4.3e-98 hypothetical protein D910_08145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.51907 BP_3 194.94 2.34 4303 189235679 XP_971393.2 226 1.7e-15 PREDICTED: sperm surface protein Sp17 [Tribolium castaneum]>gi|270004446|gb|EFA00894.1| hypothetical protein TcasGA2_TC003798 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51909 BP_3 61.06 0.58 5396 91078510 XP_969463.1 2942 0.0e+00 PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|642915541|ref|XP_008190658.1| PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|270003849|gb|EFA00297.1| hypothetical protein TcasGA2_TC003130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82094 697 2.2e-71 TATA element modulatory factor OS=Homo sapiens GN=TMF1 PE=1 SV=2 PF03376//PF02183//PF00769//PF15898//PF07926//PF10392//PF05529//PF06005//PF06810//PF13851//PF05531//PF06156 Adenovirus E3B protein//Homeobox associated leucine zipper//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//TPR/MLP1/MLP2-like protein//Golgi transport complex subunit 5//B-cell receptor-associated protein 31-like//Protein of unknown function (DUF904)//Phage minor structural protein GP20//Growth-arrest specific micro-tubule binding//Nucleopolyhedrovirus P10 protein//Protein of unknown function (DUF972) GO:0006886//GO:0006260//GO:0006606//GO:0006355//GO:0006891//GO:0048870//GO:0000917//GO:0043093 intracellular protein transport//DNA replication//protein import into nucleus//regulation of transcription, DNA-templated//intra-Golgi vesicle-mediated transport//cell motility//barrier septum assembly//FtsZ-dependent cytokinesis GO:0005198//GO:0019901//GO:0043565//GO:0003700//GO:0008092 structural molecule activity//protein kinase binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//cytoskeletal protein binding GO:0031514//GO:0019028//GO:0019898//GO:0016021//GO:0005737//GO:0005667//GO:0005783//GO:0017119//GO:0016020 motile cilium//viral capsid//extrinsic component of membrane//integral component of membrane//cytoplasm//transcription factor complex//endoplasmic reticulum//Golgi transport complex//membrane KOG4673 Transcription factor TMF, TATA element modulatory factor Cluster-8309.51912 BP_3 108.99 0.93 5920 270013632 EFA10080.1 4288 0.0e+00 hypothetical protein TcasGA2_TC012257 [Tribolium castaneum] 462320691 APGK01043568.1 65 1.98356e-22 Dendroctonus ponderosae Seq01043578, whole genome shotgun sequence K16680 ED echinoid http://www.genome.jp/dbget-bin/www_bget?ko:K16680 A2ASS6 338 1.0e-29 Titin OS=Mus musculus GN=Ttn PE=1 SV=1 PF00041//PF06682//PF13895//PF01108 Fibronectin type III domain//SOCE-associated regulatory factor of calcium homoeostasis//Immunoglobulin domain//Tissue factor GO:2001256 regulation of store-operated calcium entry GO:0005515 protein binding GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.51913 BP_3 49.16 0.95 2780 189239355 XP_974286.2 2627 4.4e-294 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 2161 1.9e-241 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 PF04851//PF00622//PF00270 Type III restriction enzyme, res subunit//SPRY domain//DEAD/DEAH box helicase -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524//GO:0005515//GO:0008026 DNA binding//hydrolase activity//nucleic acid binding//ATP binding//protein binding//ATP-dependent helicase activity -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.51914 BP_3 98.18 1.84 2858 642915391 XP_008190597.1 403 3.5e-36 PREDICTED: cytochrome c oxidase subunit 6B2 isoform X1 [Tribolium castaneum] 642915392 XM_969527.2 84 2.60789e-33 PREDICTED: Tribolium castaneum cytochrome c oxidase subunit 6B2 (LOC663486), transcript variant X2, mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 P14854 264 1.9e-21 Cytochrome c oxidase subunit 6B1 OS=Homo sapiens GN=COX6B1 PE=1 SV=2 PF07393//PF02297 Exocyst complex component Sec10//Cytochrome oxidase c subunit VIb GO:0015992//GO:0006887//GO:0048278//GO:0006123 proton transport//exocytosis//vesicle docking//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0005737//GO:0005739//GO:0045277 cytoplasm//mitochondrion//respiratory chain complex IV KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.51915 BP_3 382.87 21.96 1132 642912083 XP_008200795.1 819 7.9e-85 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27972 178 6.9e-12 Chondroadherin OS=Bos taurus GN=CHAD PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51916 BP_3 301.24 3.47 4478 91083957 XP_975021.1 668 1.0e-66 PREDICTED: caldesmon [Tribolium castaneum]>gi|270006722|gb|EFA03170.1| hypothetical protein TcasGA2_TC013090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09002 147 1.1e-07 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF14372//PF01442//PF01544//PF13741//PF08496//PF00318//PF06667//PF00836//PF02096//PF01956//PF08074 Domain of unknown function (DUF4413)//Apolipoprotein A1/A4/E domain//CorA-like Mg2+ transporter protein//Mitochondrial ribosomal protein S25//Peptidase family S49 N-terminal//Ribosomal protein S2//Phage shock protein B//Stathmin family//60Kd inner membrane protein//Integral membrane protein DUF106//CHDCT2 (NUC038) domain GO:0006869//GO:0006412//GO:0030001//GO:0042157//GO:0042254//GO:0006355//GO:0031110//GO:0051205//GO:0009271//GO:0055085 lipid transport//translation//metal ion transport//lipoprotein metabolic process//ribosome biogenesis//regulation of transcription, DNA-templated//regulation of microtubule polymerization or depolymerization//protein insertion into membrane//phage shock//transmembrane transport GO:0046873//GO:0008289//GO:0003677//GO:0016818//GO:0004252//GO:0003735//GO:0008270//GO:0005524 metal ion transmembrane transporter activity//lipid binding//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//serine-type endopeptidase activity//structural constituent of ribosome//zinc ion binding//ATP binding GO:0005576//GO:0016020//GO:0005634//GO:0005763//GO:0005886//GO:0005840//GO:0005622//GO:0016021 extracellular region//membrane//nucleus//mitochondrial small ribosomal subunit//plasma membrane//ribosome//intracellular//integral component of membrane -- -- Cluster-8309.51918 BP_3 115.12 0.71 8108 642919609 XP_008191938.1 1817 1.1e-199 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X2 [Tribolium castaneum] 642919611 XM_008193717.1 100 9.50981e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.8e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF02257//PF01388//PF12031 RFX DNA-binding domain//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518) GO:0006355//GO:0006338 regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.5192 BP_3 57.10 1.31 2389 478263509 ENN81862.1 482 2.0e-45 hypothetical protein YQE_01754, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF04111//PF07851//PF02601 Outer membrane protein (OmpH-like)//Autophagy protein Apg6//TMPIT-like protein//Exonuclease VII, large subunit GO:0006308//GO:0006914 DNA catabolic process//autophagy GO:0051082//GO:0008855 unfolded protein binding//exodeoxyribonuclease VII activity GO:0016021//GO:0009318 integral component of membrane//exodeoxyribonuclease VII complex -- -- Cluster-8309.51920 BP_3 34.82 1.61 1332 642932849 XP_008197011.1 848 4.0e-88 PREDICTED: NAD kinase-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 P58058 580 2.0e-58 NAD kinase OS=Mus musculus GN=Nadk PE=1 SV=2 PF00781//PF01513 Diacylglycerol kinase catalytic domain//ATP-NAD kinase GO:0006769//GO:0046497//GO:0008152//GO:0006741 nicotinamide metabolic process//nicotinate nucleotide metabolic process//metabolic process//NADP biosynthetic process GO:0003951//GO:0016301 NAD+ kinase activity//kinase activity -- -- KOG2178 Predicted sugar kinase Cluster-8309.51921 BP_3 385.33 3.61 5433 546683205 ERL93045.1 2710 2.0e-303 hypothetical protein D910_10347 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96JG6 1322 7.4e-144 Syndetin OS=Homo sapiens GN=CCDC132 PE=1 SV=3 PF08718//PF04189//PF12422//PF04048 Glycolipid transfer protein (GLTP)//Gcd10p family//Condensin II non structural maintenance of chromosomes subunit//Sec8 exocyst complex component specific domain GO:0006904//GO:0030488//GO:0046836//GO:0015031 vesicle docking involved in exocytosis//tRNA methylation//glycolipid transport//protein transport GO:0017089//GO:0051861 glycolipid transporter activity//glycolipid binding GO:0005634//GO:0000145//GO:0031515//GO:0005737 nucleus//exocyst//tRNA (m1A) methyltransferase complex//cytoplasm KOG2939 Uncharacterized conserved protein Cluster-8309.51922 BP_3 34.58 0.32 5527 546683205 ERL93045.1 2710 2.1e-303 hypothetical protein D910_10347 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96JG6 1322 7.5e-144 Syndetin OS=Homo sapiens GN=CCDC132 PE=1 SV=3 PF12422//PF04048//PF04189//PF08718 Condensin II non structural maintenance of chromosomes subunit//Sec8 exocyst complex component specific domain//Gcd10p family//Glycolipid transfer protein (GLTP) GO:0046836//GO:0006904//GO:0030488//GO:0015031 glycolipid transport//vesicle docking involved in exocytosis//tRNA methylation//protein transport GO:0017089//GO:0051861 glycolipid transporter activity//glycolipid binding GO:0005634//GO:0000145//GO:0005737//GO:0031515 nucleus//exocyst//cytoplasm//tRNA (m1A) methyltransferase complex KOG2939 Uncharacterized conserved protein Cluster-8309.51924 BP_3 28.96 0.87 1905 571330962 AHF27413.1 1329 9.7e-144 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A5LGM7 437 1.1e-41 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.51925 BP_3 124.35 3.55 1980 642918258 XP_008191434.1 1452 5.5e-158 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918260|ref|XP_008191435.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918262|ref|XP_008191436.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 Q1HG43 346 4.0e-31 Dual oxidase maturation factor 1 OS=Homo sapiens GN=DUOXA1 PE=1 SV=1 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG3921 Uncharacterized conserved protein Cluster-8309.51926 BP_3 80.71 0.37 10838 642935463 XP_008198020.1 2819 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X1 [Tribolium castaneum] 642935470 XM_967302.3 113 7.55176e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- Q6A0A9 763 9.7e-79 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 PF01328//PF00083//PF07690 Peroxidase, family 2//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006979//GO:0006804//GO:0055085 response to oxidative stress//obsolete peroxidase reaction//transmembrane transport GO:0004601//GO:0022857 peroxidase activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.51927 BP_3 542.42 10.65 2747 642935463 XP_008198020.1 2980 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X1 [Tribolium castaneum] 820850190 XM_012487292.1 50 1.99231e-14 PREDICTED: Apis florea constitutive coactivator of PPAR-gamma-like protein 1 homolog (LOC100866531), mRNA -- -- -- -- Q6A0A9 755 2.1e-78 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51928 BP_3 1396.91 6.88 10083 642935465 XP_008198021.1 3334 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X2 [Tribolium castaneum] 642935470 XM_967302.3 113 7.02389e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- Q6A0A9 763 9.0e-79 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 PF07690//PF00083//PF01328 Major Facilitator Superfamily//Sugar (and other) transporter//Peroxidase, family 2 GO:0006804//GO:0006979//GO:0055085 obsolete peroxidase reaction//response to oxidative stress//transmembrane transport GO:0004601//GO:0022857 peroxidase activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.51930 BP_3 5.00 1.17 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51932 BP_3 1.00 1.16 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51934 BP_3 7.00 0.34 1280 111182472 ABH07674.1 1551 1.2e-169 gut-specific chitinase [Apriona germari]>gi|111182474|gb|ABH07675.1| gut-specific chitinase [Apriona germari] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 706 4.7e-73 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0006032//GO:0016998//GO:0005975 chitin catabolic process//cell wall macromolecule catabolic process//carbohydrate metabolic process GO:0004553//GO:0043169//GO:0004568 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//chitinase activity -- -- -- -- Cluster-8309.51936 BP_3 156.41 5.14 1757 642914399 XP_974973.2 1511 7.0e-165 PREDICTED: uncharacterized protein LOC663847 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ7 199 3.9e-14 PI-PLC X domain-containing protein 1 OS=Homo sapiens GN=PLCXD1 PE=2 SV=1 PF03490 Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.5194 BP_3 13.47 4.70 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51940 BP_3 143.71 1.59 4644 91082383 XP_968748.1 3454 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 462340820 APGK01036268.1 160 2.40479e-75 Dendroctonus ponderosae Seq01036278, whole genome shotgun sequence K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2490 2.3e-279 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00004//PF02714//PF01926//PF13304//PF00664//PF00931//PF03193//PF00005//PF02367//PF06414//PF01637 ATPase family associated with various cellular activities (AAA)//Calcium-dependent channel, 7TM region, putative phosphate//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//NB-ARC domain//Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Archaeal ATPase GO:0002949//GO:0055085//GO:0006810 tRNA threonylcarbamoyladenosine modification//transmembrane transport//transport GO:0016301//GO:0016887//GO:0005525//GO:0017111//GO:0042626//GO:0005524//GO:0003924//GO:0043531 kinase activity//ATPase activity//GTP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//ADP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.51944 BP_3 22.45 0.68 1894 642915648 XP_008190695.1 1161 2.9e-124 PREDICTED: uncharacterized protein LOC103312267 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DCD5 235 2.8e-18 Tight junction-associated protein 1 OS=Mus musculus GN=Tjap1 PE=1 SV=1 PF01890//PF05791//PF07989 Cobalamin synthesis G C-terminus//Bacillus haemolytic enterotoxin (HBL)//Centrosomin N-terminal motif 1 GO:0009236//GO:0009405 cobalamin biosynthetic process//pathogenesis -- -- GO:0016020//GO:0005815 membrane//microtubule organizing center -- -- Cluster-8309.51945 BP_3 18.18 0.37 2643 270005721 EFA02169.1 703 5.2e-71 hypothetical protein TcasGA2_TC007825 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51946 BP_3 10.00 1.56 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51947 BP_3 6.56 0.33 1247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51948 BP_3 13.00 0.40 1851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51949 BP_3 105.41 0.78 6786 642910887 XP_008193450.1 6367 0.0e+00 PREDICTED: calcium-dependent secretion activator isoform X5 [Tribolium castaneum] 642910886 XM_008195228.1 1696 0 PREDICTED: Tribolium castaneum calcium-dependent secretion activator (LOC660877), transcript variant X6, mRNA -- -- -- -- Q9NHE5 4160 0.0e+00 Calcium-dependent secretion activator OS=Drosophila melanogaster GN=Caps PE=1 SV=3 PF11615 Protein of unknown function (DUF3249) GO:0000266 mitochondrial fission -- -- GO:0005739 mitochondrion KOG3543 Ca2+-dependent activator protein Cluster-8309.51951 BP_3 251.01 2.81 4602 91077854 XP_972003.1 1769 2.2e-194 PREDICTED: tetratricopeptide repeat protein 7B [Tribolium castaneum]>gi|270002262|gb|EEZ98709.1| hypothetical protein TcasGA2_TC001250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86TV6 697 1.9e-71 Tetratricopeptide repeat protein 7B OS=Homo sapiens GN=TTC7B PE=1 SV=3 PF13414//PF13176//PF13371//PF13181//PF13374//PF00515 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4162 Predicted calmodulin-binding protein Cluster-8309.51953 BP_3 806.55 9.79 4264 642930462 XP_008196413.1 2488 8.8e-278 PREDICTED: phosphofurin acidic cluster sorting protein 1 [Tribolium castaneum]>gi|270009398|gb|EFA05846.1| hypothetical protein TcasGA2_TC008635 [Tribolium castaneum] 558214452 XM_006108296.1 57 3.99102e-18 PREDICTED: Myotis lucifugus phosphofurin acidic cluster sorting protein 2 (PACS2), partial mRNA -- -- -- -- Q5ZKF4 633 4.5e-64 High mobility group protein 20A OS=Gallus gallus GN=HMG20A PE=2 SV=1 PF01496//PF04513//PF07851 V-type ATPase 116kDa subunit family//Baculovirus polyhedron envelope protein, PEP, C terminus//TMPIT-like protein GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0005198//GO:0015078 structural molecule activity//hydrogen ion transmembrane transporter activity GO:0019028//GO:0016021//GO:0019031//GO:0033179 viral capsid//integral component of membrane//viral envelope//proton-transporting V-type ATPase, V0 domain KOG0381 HMG box-containing protein Cluster-8309.51956 BP_3 153.84 2.87 2875 91077428 XP_975436.1 1252 1.2e-134 PREDICTED: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A [Tribolium castaneum]>gi|270001628|gb|EEZ98075.1| hypothetical protein TcasGA2_TC000482 [Tribolium castaneum] -- -- -- -- -- K07442 TRM61, GCD14 tRNA (adenine57-N1/adenine58-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07442 A6H791 696 1.5e-71 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Bos taurus GN=TRMT61A PE=2 SV=1 PF01135//PF06816//PF03009//PF08704 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//NOTCH protein//Glycerophosphoryl diester phosphodiesterase family//tRNA methyltransferase complex GCD14 subunit GO:0008033//GO:0046500//GO:0030154//GO:0006479//GO:0009451//GO:0030488//GO:0006629//GO:0006464 tRNA processing//S-adenosylmethionine metabolic process//cell differentiation//protein methylation//RNA modification//tRNA methylation//lipid metabolic process//cellular protein modification process GO:0008081//GO:0004719//GO:0016429 phosphoric diester hydrolase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (adenine-N1-)-methyltransferase activity GO:0031515//GO:0016021 tRNA (m1A) methyltransferase complex//integral component of membrane KOG2915 tRNA(1-methyladenosine) methyltransferase, subunit GCD14 Cluster-8309.51960 BP_3 445.33 5.81 3983 91082137 XP_966595.1 1646 3.5e-180 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 178 2.03089e-85 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1351 2.3e-147 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.51963 BP_3 2136.20 19.44 5589 478254436 ENN74688.1 2866 0.0e+00 hypothetical protein YQE_08805, partial [Dendroctonus ponderosae] 697484427 XM_009675369.1 47 1.89866e-12 PREDICTED: Struthio camelus australis methionyl-tRNA synthetase (MARS), partial mRNA K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q6PF21 2041 3.2e-227 Methionine--tRNA ligase, cytoplasmic OS=Xenopus laevis GN=mars PE=2 SV=1 PF09334//PF00133//PF08264 tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding -- -- KOG1247 Methionyl-tRNA synthetase Cluster-8309.51965 BP_3 34.18 0.31 5596 642923061 XP_008200515.1 1804 2.4e-198 PREDICTED: sphingomyelin synthase-related 1-like [Tribolium castaneum]>gi|270006596|gb|EFA03044.1| hypothetical protein TcasGA2_TC010470 [Tribolium castaneum] 755974579 XM_011309074.1 145 6.32548e-67 PREDICTED: Fopius arisanus sphingomyelin synthase-related 1 (LOC105269082), mRNA -- -- -- -- Q9VS60 1131 1.1e-121 Sphingomyelin synthase-related 1 OS=Drosophila melanogaster GN=SMSr PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3330 Transport protein particle (TRAPP) complex subunit Cluster-8309.51966 BP_3 29.65 0.95 1796 91092400 XP_969218.1 1236 5.6e-133 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 492 4.3e-48 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.51967 BP_3 222.14 7.90 1647 91092400 XP_969218.1 1514 3.0e-165 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 624 1.9e-63 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.51968 BP_3 7.58 0.52 998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51972 BP_3 9.69 0.62 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51973 BP_3 548.52 97.79 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51974 BP_3 126.54 6.44 1239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51978 BP_3 4.00 9.12 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5198 BP_3 20.00 1.13 1148 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51980 BP_3 2.14 0.35 586 270006237 EFA02685.1 577 4.7e-57 hypothetical protein TcasGA2_TC008406 [Tribolium castaneum] 573910381 XM_006642846.1 154 6.23962e-73 PREDICTED: Lepisosteus oculatus serine/threonine-protein phosphatase PP1-beta catalytic subunit-like (LOC102696354), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 P62207 526 1.6e-52 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Gallus gallus GN=PPP1CB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.51981 BP_3 165.49 2.06 4168 642918835 XP_008191606.1 4250 0.0e+00 PREDICTED: DENN domain-containing protein 5B [Tribolium castaneum]>gi|270005624|gb|EFA02072.1| hypothetical protein TcasGA2_TC007707 [Tribolium castaneum] 571543384 XM_006559642.1 37 5.11739e-07 PREDICTED: Apis mellifera DENN domain-containing protein 5B-like (LOC412128), transcript variant X4, mRNA -- -- -- -- A2RSQ0 1907 8.3e-212 DENN domain-containing protein 5B OS=Mus musculus GN=Dennd5b PE=1 SV=2 PF01807//PF01477 CHC2 zinc finger//PLAT/LH2 domain GO:0006260//GO:0006269//GO:0006351 DNA replication//DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0008270//GO:0003677//GO:0003896//GO:0005515 zinc ion binding//DNA binding//DNA primase activity//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2080 Uncharacterized conserved protein, contains DENN and RUN domains Cluster-8309.51985 BP_3 499.00 24.24 1284 768431187 XP_011556858.1 403 1.6e-36 PREDICTED: probable small nuclear ribonucleoprotein Sm D2 [Plutella xylostella] -- -- -- -- -- K11096 SNRPD2, SMD2 small nuclear ribonucleoprotein D2 http://www.genome.jp/dbget-bin/www_bget?ko:K11096 Q18786 385 7.8e-36 Probable small nuclear ribonucleoprotein Sm D2 OS=Caenorhabditis elegans GN=snr-4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3459 Small nuclear ribonucleoprotein (snRNP) Sm core protein Cluster-8309.51986 BP_3 8.00 0.72 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51987 BP_3 104.85 1.51 3645 642916726 XP_008192366.1 1461 9.2e-159 PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum]>gi|642916728|ref|XP_008192372.1| PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 137 1.3e-06 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51989 BP_3 50.38 1.28 2195 642919559 XP_008191923.1 2104 1.5e-233 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270005853|gb|EFA02301.1| hypothetical protein TcasGA2_TC007966 [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50430 782 1.2e-81 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.51991 BP_3 6302.91 55.79 5737 642930100 XP_008196251.1 2972 0.0e+00 PREDICTED: putative epidermal cell surface receptor isoform X2 [Tribolium castaneum] 195454384 XM_002074181.1 39 5.45815e-08 Drosophila willistoni GK14524 (Dwil\GK14524), mRNA -- -- -- -- Q04164 1071 9.9e-115 Putative epidermal cell surface receptor OS=Drosophila melanogaster GN=sas PE=2 SV=2 PF00093//PF02556//PF00041 von Willebrand factor type C domain//Preprotein translocase subunit SecB//Fibronectin type III domain GO:0051262//GO:0015031 protein tetramerization//protein transport GO:0051082//GO:0005515 unfolded protein binding//protein binding -- -- -- -- Cluster-8309.51999 BP_3 31.00 1.36 1392 642928332 XP_008195538.1 1043 1.0e-110 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 P54316 372 2.7e-34 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 PF01764//PF06821//PF07819 Lipase (class 3)//Serine hydrolase//PGAP1-like protein GO:0006505//GO:0006886//GO:0006629 GPI anchor metabolic process//intracellular protein transport//lipid metabolic process GO:0016787//GO:0016788//GO:0003824 hydrolase activity//hydrolase activity, acting on ester bonds//catalytic activity -- -- -- -- Cluster-8309.520 BP_3 351.00 17.36 1266 270011432 EFA07880.1 258 9.9e-20 hypothetical protein TcasGA2_TC005454 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52002 BP_3 16.14 0.69 1425 642913929 XP_008201218.1 1052 9.5e-112 PREDICTED: headcase protein [Tribolium castaneum] 642913928 XM_008202996.1 311 8.32297e-160 PREDICTED: Tribolium castaneum headcase protein (LOC664275), mRNA -- -- -- -- Q9N2M8 397 3.5e-37 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52003 BP_3 2.02 4.50 292 820132938 KKX07222.1 313 9.6e-27 ribose-phosphate pyrophosphokinase 1 [Scleropages formosus] -- -- -- -- -- K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 Q9D7G0 303 5.7e-27 Ribose-phosphate pyrophosphokinase 1 OS=Mus musculus GN=Prps1 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.52004 BP_3 82.79 7.67 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52009 BP_3 1.00 0.52 382 642936833 XP_008197835.1 198 2.7e-13 PREDICTED: calcium-activated potassium channel slowpoke isoform X1 [Tribolium castaneum] 642936832 XM_008199613.1 87 6.93866e-36 PREDICTED: Tribolium castaneum calcium-activated potassium channel slowpoke (LOC657078), transcript variant X1, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 149 5.4e-09 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF03493 Calcium-activated BK potassium channel alpha subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.5201 BP_3 66.93 0.58 5900 91085743 XP_973670.1 2112 4.8e-234 PREDICTED: Fanconi anemia group M protein homolog [Tribolium castaneum] 884966605 XM_013137615.1 65 1.97682e-22 PREDICTED: Esox lucius Fanconi anemia, complementation group M (fancm), mRNA K10896 FANCM fanconi anemia group M protein http://www.genome.jp/dbget-bin/www_bget?ko:K10896 Q8IYD8 1231 2.9e-133 Fanconi anemia group M protein OS=Homo sapiens GN=FANCM PE=1 SV=2 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0354 DEAD-box like helicase Cluster-8309.52010 BP_3 66.00 0.79 4313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52012 BP_3 908.37 9.58 4862 478252787 ENN73180.1 1403 6.5e-152 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 5.6e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4780 Uncharacterized conserved protein Cluster-8309.52019 BP_3 216.69 3.38 3384 642920751 XP_008192546.1 1717 1.8e-188 PREDICTED: pre-mRNA cleavage complex 2 protein Pcf11 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 433 5.6e-41 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.52020 BP_3 189.82 1.01 9358 270006108 EFA02556.1 1470 2.1e-159 hypothetical protein TcasGA2_TC008263 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 436 6.9e-41 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 PF08916 Phenylalanine zipper GO:0035556//GO:0007165 intracellular signal transduction//signal transduction GO:0004871 signal transducer activity -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.52024 BP_3 21.00 2.16 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52026 BP_3 513.34 15.73 1865 270014347 EFA10795.1 637 1.7e-63 nuclear transport factor-2 [Tribolium castaneum] 572260423 XM_006608467.1 134 2.71314e-61 PREDICTED: Apis dorsata probable nuclear transport factor 2-like (LOC102679089), transcript variant X1, mRNA -- -- -- -- Q21735 314 1.9e-27 Probable nuclear transport factor 2 OS=Caenorhabditis elegans GN=ran-4 PE=3 SV=1 PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular KOG2104 Nuclear transport factor 2 Cluster-8309.52028 BP_3 7.77 0.31 1495 642937919 XP_008199130.1 1094 1.4e-116 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9B9 311 3.5e-27 Choline transporter-like protein 1 OS=Torpedo marmorata GN=slc44a1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.52030 BP_3 41.22 1.80 1393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52031 BP_3 2669.58 66.45 2228 642923071 XP_008193599.1 2072 7.9e-230 PREDICTED: matrix metalloproteinase 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q99PW6 812 4.1e-85 Matrix metalloproteinase-24 OS=Rattus norvegicus GN=Mmp24 PE=1 SV=1 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.52032 BP_3 473.36 6.91 3593 255958232 NP_001157646.1 2108 8.5e-234 matrix metalloproteinase 1 isoform 1 precursor [Tribolium castaneum]>gi|270008219|gb|EFA04667.1| matrix metalloproteinase 1 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q10739 816 2.3e-85 Matrix metalloproteinase-14 OS=Rattus norvegicus GN=Mmp14 PE=2 SV=2 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0008270//GO:0005509//GO:0004222 zinc ion binding//calcium ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix -- -- Cluster-8309.52033 BP_3 224.25 5.25 2350 255958232 NP_001157646.1 2108 5.6e-234 matrix metalloproteinase 1 isoform 1 precursor [Tribolium castaneum]>gi|270008219|gb|EFA04667.1| matrix metalloproteinase 1 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q10739 816 1.5e-85 Matrix metalloproteinase-14 OS=Rattus norvegicus GN=Mmp14 PE=2 SV=2 PF00413//PF01400 Matrixin//Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0005509//GO:0004222//GO:0008270 calcium ion binding//metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.52035 BP_3 2.00 4.56 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52036 BP_3 18.00 5.54 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52037 BP_3 1084.43 26.95 2231 546675654 ERL86804.1 1778 9.8e-196 hypothetical protein D910_04208 [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 Q8WY07 1135 1.5e-122 Cationic amino acid transporter 3 OS=Homo sapiens GN=SLC7A3 PE=1 SV=1 PF00324//PF15020//PF13520 Amino acid permease//Cation channel sperm-associated protein subunit delta//Amino acid permease GO:0006810//GO:0006865//GO:0055085//GO:0003333 transport//amino acid transport//transmembrane transport//amino acid transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016020//GO:0036128 membrane//CatSper complex KOG1286 Amino acid transporters Cluster-8309.52039 BP_3 19.52 0.73 1586 270000811 EEZ97258.1 1464 1.8e-159 hypothetical protein TcasGA2_TC011058 [Tribolium castaneum] -- -- -- -- -- K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P39054 1386 8.1e-152 Dynamin-2 OS=Mus musculus GN=Dnm2 PE=1 SV=2 PF01031//PF01926//PF01297//PF08477 Dynamin central region//50S ribosome-binding GTPase//Zinc-uptake complex component A periplasmic//Ras of Complex, Roc, domain of DAPkinase GO:0030001//GO:0007264 metal ion transport//small GTPase mediated signal transduction GO:0005525//GO:0046872 GTP binding//metal ion binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.52040 BP_3 376.90 6.69 3006 642937407 XP_008198823.1 2845 0.0e+00 PREDICTED: dynamin isoform X2 [Tribolium castaneum] -- -- -- -- -- K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 2587 8.4e-291 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF02212//PF01926//PF01031 Dynamin GTPase effector domain//50S ribosome-binding GTPase//Dynamin central region -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.52042 BP_3 6.75 1.83 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52043 BP_3 1.00 6.33 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52047 BP_3 9.09 0.83 821 91080861 XP_971851.1 262 2.2e-20 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [Tribolium castaneum]>gi|270006430|gb|EFA02878.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 [Tribolium castaneum] -- -- -- -- -- K03954 NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03954 P91929 161 4.7e-10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Drosophila melanogaster GN=ND42 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5205 BP_3 5.00 0.54 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52052 BP_3 59.08 2.23 1566 642925505 XP_008194578.1 1185 4.0e-127 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase [Tribolium castaneum]>gi|270008695|gb|EFA05143.1| hypothetical protein TcasGA2_TC015260 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q7SY06 550 7.0e-55 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio GN=hacd3 PE=2 SV=2 PF06687 SUR7/PalI family -- -- -- -- GO:0005886 plasma membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.52053 BP_3 128.38 1.87 3602 478263518 ENN81868.1 427 7.2e-39 hypothetical protein YQE_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68EI3 201 4.7e-14 Cytosolic carboxypeptidase-like protein 5 OS=Danio rerio GN=agbl5 PE=2 SV=1 PF05656//PF06638 Protein of unknown function (DUF805)//Strabismus protein GO:0007275 multicellular organismal development -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.52054 BP_3 289.47 2.41 6076 612026501 XP_007492212.1 603 4.7e-59 PREDICTED: zinc finger protein 91-like [Monodelphis domestica] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NYT6 585 2.4e-58 Zinc finger protein 226 OS=Homo sapiens GN=ZNF226 PE=2 SV=2 PF13912//PF00130//PF02053//PF00096//PF13465 C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Gene 66 (IR5) protein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0035556 intracellular signal transduction GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.52055 BP_3 19.36 0.64 1754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52057 BP_3 150.76 4.09 2067 332372486 AEE61385.1 1589 7.5e-174 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5LJP9 903 1.1e-95 Asparagine synthetase domain-containing protein CG17486 OS=Drosophila melanogaster GN=CG17486 PE=2 SV=2 PF00733 Asparagine synthase GO:0006531//GO:0006522//GO:0006529 aspartate metabolic process//alanine metabolic process//asparagine biosynthetic process GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0573 Asparagine synthase Cluster-8309.52058 BP_3 29.70 1.08 1623 642914104 XP_008201544.1 491 1.2e-46 PREDICTED: altered inheritance of mitochondria protein 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52062 BP_3 13.67 0.33 2301 2660868 AAC48288.1 1073 5.7e-114 fast tropomyosin isoform [Homarus americanus] 151505278 EF672351.1 814 0 Scylla serrata tropomyosin mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 O44119 1117 1.8e-120 Tropomyosin OS=Homarus americanus GN=TM1 PE=1 SV=1 PF05557//PF00769//PF10473//PF05739//PF06160//PF16716//PF04111//PF01929//PF02601//PF08702//PF07926//PF06109//PF14073//PF06008//PF06009//PF00435 Mitotic checkpoint protein//Ezrin/radixin/moesin family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Septation ring formation regulator, EzrA//Bone marrow stromal antigen 2//Autophagy protein Apg6//Ribosomal protein L14//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//TPR/MLP1/MLP2-like protein//Haemolysin E (HlyE)//Centrosome localisation domain of Cep57//Laminin Domain I//Laminin Domain II//Spectrin repeat GO:0051258//GO:0006914//GO:0009405//GO:0007165//GO:0030334//GO:0044179//GO:0006308//GO:0007155//GO:0030155//GO:0007094//GO:0051607//GO:0006412//GO:0042254//GO:0045995//GO:0006606//GO:0030168//GO:0000921 protein polymerization//autophagy//pathogenesis//signal transduction//regulation of cell migration//hemolysis in other organism//DNA catabolic process//cell adhesion//regulation of cell adhesion//mitotic spindle assembly checkpoint//defense response to virus//translation//ribosome biogenesis//regulation of embryonic development//protein import into nucleus//platelet activation//septin ring assembly GO:0042803//GO:0043015//GO:0008855//GO:0005515//GO:0042802//GO:0003735//GO:0005102//GO:0008134//GO:0045502//GO:0030674//GO:0008092 protein homodimerization activity//gamma-tubulin binding//exodeoxyribonuclease VII activity//protein binding//identical protein binding//structural constituent of ribosome//receptor binding//transcription factor binding//dynein binding//protein binding, bridging//cytoskeletal protein binding GO:0005737//GO:0005840//GO:0005622//GO:0005940//GO:0016021//GO:0005577//GO:0009318//GO:0045298//GO:0019898//GO:0005667//GO:0030286 cytoplasm//ribosome//intracellular//septin ring//integral component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//tubulin complex//extrinsic component of membrane//transcription factor complex//dynein complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.52064 BP_3 1.00 1.72 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52065 BP_3 121.32 1.01 6101 642920114 XP_008192211.1 1223 6.1e-131 PREDICTED: E3 ubiquitin-protein ligase SH3RF1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.3e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF00097//PF14634//PF17123//PF00096//PF16622//PF14604//PF00018//PF13912//PF09360//PF02892//PF13639//PF13465 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-like zinc finger//Zinc finger, C2H2 type//zinc-finger C2H2-type//Variant SH3 domain//SH3 domain//C2H2-type zinc finger//Iron-binding zinc finger CDGSH type//BED zinc finger//Ring finger domain//Zinc-finger double domain -- -- GO:0046872//GO:0005515//GO:0003677//GO:0051537//GO:0008270 metal ion binding//protein binding//DNA binding//2 iron, 2 sulfur cluster binding//zinc ion binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.52067 BP_3 20.07 0.38 2841 780649216 XP_011689959.1 1304 1.1e-140 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52068 BP_3 54.40 3.14 1126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52069 BP_3 35.78 1.48 1456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52074 BP_3 25.87 0.60 2372 189233695 XP_001812208.1 495 6.2e-47 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 370 7.9e-34 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.52077 BP_3 18.83 2.42 667 478259666 ENN79510.1 176 1.7e-10 hypothetical protein YQE_03973, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52079 BP_3 460.06 4.07 5737 642923585 XP_008193571.1 1658 2.1e-181 PREDICTED: run domain Beclin-1 interacting and cysteine-rich containing protein [Tribolium castaneum] -- -- -- -- -- K19330 KIAA0226 run domain Beclin-1 interacting and cysteine-rich containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K19330 Q92622 802 1.5e-83 Run domain Beclin-1 interacting and cysteine-rich containing protein OS=Homo sapiens GN=KIAA0226 PE=1 SV=4 PF08506//PF14721//PF00628 Cse1//Apoptosis-inducing factor, mitochondrion-associated, C-term//PHD-finger GO:0006886 intracellular protein transport GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.5208 BP_3 9.00 0.41 1346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52085 BP_3 2.00 1.35 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52087 BP_3 9.06 0.98 737 332376162 AEE63221.1 273 1.1e-21 unknown [Dendroctonus ponderosae]>gi|478261356|gb|ENN80760.1| hypothetical protein YQE_02821, partial [Dendroctonus ponderosae]>gi|546678771|gb|ERL89323.1| hypothetical protein D910_06695 [Dendroctonus ponderosae] 765338024 XM_011494945.1 62 1.1033e-21 Aedes aegypti AAEL004475-RB mRNA K05756 ARPC3 actin related protein 2/3 complex, subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05756 Q9JM76 213 3.9e-16 Actin-related protein 2/3 complex subunit 3 OS=Mus musculus GN=Arpc3 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3155 Actin-related protein Arp2/3 complex, subunit ARPC3 Cluster-8309.52088 BP_3 2.00 79.24 211 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52090 BP_3 13.00 0.45 1684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52091 BP_3 98.29 3.78 1545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52095 BP_3 3.00 0.98 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52097 BP_3 754.98 3.79 9902 642928417 XP_008193778.1 1636 1.3e-178 PREDICTED: transcriptional regulator ATRX homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 F4HW51 979 8.0e-104 Protein CHROMATIN REMODELING 20 OS=Arabidopsis thaliana GN=ATRX PE=2 SV=2 PF00176//PF02729 SNF2 family N-terminal domain//Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GO:0006520 cellular amino acid metabolic process GO:0005524//GO:0016743 ATP binding//carboxyl- or carbamoyltransferase activity -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.52098 BP_3 59.54 2.44 1467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08064//PF00125 UME (NUC010) domain//Core histone H2A/H2B/H3/H4 GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0003677//GO:0004674 DNA binding//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.521 BP_3 4.39 0.50 713 270007789 EFA04237.1 176 1.8e-10 hypothetical protein TcasGA2_TC014490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01320 Colicin immunity protein / pyocin immunity protein GO:0006955 immune response GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.5210 BP_3 20.52 0.44 2525 642935762 XP_008198164.1 1462 4.9e-159 PREDICTED: uncharacterized protein C2orf42 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SYX3 696 1.3e-71 Uncharacterized protein C2orf42 homolog OS=Bos taurus PE=2 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.52100 BP_3 406.86 22.18 1176 332373564 AEE61923.1 917 3.5e-96 unknown [Dendroctonus ponderosae]>gi|478264341|gb|ENN82218.1| hypothetical protein YQE_01408, partial [Dendroctonus ponderosae]>gi|478266738|gb|ENN82887.1| hypothetical protein YQE_00749, partial [Dendroctonus ponderosae]>gi|546683553|gb|ERL93351.1| hypothetical protein D910_10643 [Dendroctonus ponderosae] 644995449 XM_001599589.3 181 1.26227e-87 PREDICTED: Nasonia vitripennis ADP-ribosylation factor-like protein 1 (LOC100114707), mRNA K07942 ARL1 ADP-ribosylation factor-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07942 P25160 807 8.3e-85 ADP-ribosylation factor-like protein 1 OS=Drosophila melanogaster GN=Arl1 PE=2 SV=5 PF01926//PF08477//PF02421//PF00025//PF00005//PF03193//PF04670//PF10662//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//ABC transporter//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//G-protein alpha subunit GO:0007186//GO:0015684//GO:0007264//GO:0006576//GO:0007165 G-protein coupled receptor signaling pathway//ferrous iron transport//small GTPase mediated signal transduction//cellular biogenic amine metabolic process//signal transduction GO:0019001//GO:0004871//GO:0016887//GO:0005525//GO:0031683//GO:0005524//GO:0015093//GO:0003924 guanyl nucleotide binding//signal transducer activity//ATPase activity//GTP binding//G-protein beta/gamma-subunit complex binding//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.52102 BP_3 42.00 3.81 823 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52105 BP_3 8.35 0.34 1466 91091486 XP_968262.1 699 8.4e-71 PREDICTED: phospholipase A1 [Tribolium castaneum]>gi|270000939|gb|EEZ97386.1| hypothetical protein TcasGA2_TC011212 [Tribolium castaneum] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q6Q252 289 1.2e-24 Phospholipase A1 1 OS=Polistes dominula PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52109 BP_3 32.52 0.98 1887 642937972 XP_008199150.1 274 2.1e-21 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52117 BP_3 219.92 8.62 1522 270014308 EFA10756.1 1447 1.6e-157 cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1017 4.8e-109 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067//PF01618 Cytochrome P450//MotA/TolQ/ExbB proton channel family GO:0015031//GO:0055114//GO:0006810 protein transport//oxidation-reduction process//transport GO:0005506//GO:0020037//GO:0008565//GO:0016705 iron ion binding//heme binding//protein transporter activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016020 membrane -- -- Cluster-8309.52120 BP_3 144.64 2.16 3522 642927427 XP_008195268.1 1097 1.4e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52121 BP_3 71.00 7.45 751 56112341 AAV71145.1 1156 4.4e-124 ribosomal protein L10 [Callinectes sapidus] 56112340 AY822650.1 410 0 Callinectes sapidus ribosomal protein L10 mRNA, complete cds K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O61231 1002 1.3e-107 60S ribosomal protein L10 OS=Drosophila melanogaster GN=RpL10 PE=1 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.52122 BP_3 29.00 4.95 574 410925912 XP_003976423.1 581 1.6e-57 PREDICTED: 60S ribosomal protein L18a [Takifugu rubripes] 545198928 XM_005604118.1 113 3.77909e-50 PREDICTED: Equus caballus ribosomal protein L18a (RPL18A), mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q7ZWJ4 580 8.5e-59 60S ribosomal protein L18a OS=Danio rerio GN=rpl18a PE=2 SV=1 PF01775 Ribosomal L18ae/LX protein domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.52126 BP_3 33.27 0.89 2090 724860998 XP_010368879.1 518 1.2e-49 PREDICTED: zinc finger protein 107-like, partial [Rhinopithecus roxellana] 158294380 XM_315566.4 143 3.02525e-66 Anopheles gambiae str. PEST AGAP005562-PA (AgaP_AGAP005562) mRNA, complete cds K10611 RBX2, ROC2, RNF7 RING-box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10611 Q05481 450 3.7e-43 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF13639//PF13912//PF06003//PF12861//PF16622//PF00096//PF12678//PF17123//PF00097//PF07776 Zinc-finger double domain//Ring finger domain//C2H2-type zinc finger//Survival motor neuron protein (SMN)//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//RING-H2 zinc finger//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger associated domain (zf-AD) GO:0016567//GO:0006397 protein ubiquitination//mRNA processing GO:0046872//GO:0008270//GO:0004842//GO:0005515//GO:0003723 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding//RNA binding GO:0005737//GO:0005680//GO:0005634 cytoplasm//anaphase-promoting complex//nucleus -- -- Cluster-8309.52127 BP_3 163.27 3.20 2754 532058550 XP_005371968.1 469 7.4e-44 PREDICTED: zinc finger protein 208-like [Microtus ochrogaster] 158294380 XM_315566.4 143 4.00002e-66 Anopheles gambiae str. PEST AGAP005562-PA (AgaP_AGAP005562) mRNA, complete cds K10611 RBX2, ROC2, RNF7 RING-box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10611 Q9P2J8 437 1.6e-41 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF12678//PF17123//PF07776//PF00097//PF00096//PF06003//PF12861//PF13912//PF16622//PF13465//PF13639 RING-H2 zinc finger//RING-like zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Survival motor neuron protein (SMN)//Anaphase-promoting complex subunit 11 RING-H2 finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Ring finger domain GO:0016567//GO:0006397 protein ubiquitination//mRNA processing GO:0005515//GO:0004842//GO:0003723//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//RNA binding//metal ion binding//zinc ion binding GO:0005680//GO:0005634//GO:0005737 anaphase-promoting complex//nucleus//cytoplasm -- -- Cluster-8309.52129 BP_3 56.57 1.82 1791 724860998 XP_010368879.1 508 1.4e-48 PREDICTED: zinc finger protein 107-like, partial [Rhinopithecus roxellana] 158294380 XM_315566.4 143 2.58508e-66 Anopheles gambiae str. PEST AGAP005562-PA (AgaP_AGAP005562) mRNA, complete cds K10611 RBX2, ROC2, RNF7 RING-box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10611 P17035 450 3.2e-43 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF00096//PF00097//PF17123//PF12678//PF13639//PF07975//PF13465//PF16622//PF00412//PF12861//PF13912 Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//Ring finger domain//TFIIH C1-like domain//Zinc-finger double domain//zinc-finger C2H2-type//LIM domain//Anaphase-promoting complex subunit 11 RING-H2 finger//C2H2-type zinc finger GO:0006281//GO:0016567 DNA repair//protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.52131 BP_3 21.89 0.54 2236 488508184 XP_004446587.1 476 9.3e-45 PREDICTED: zinc finger protein 624 isoform X4 [Dasypus novemcinctus] 158294380 XM_315566.4 143 3.24018e-66 Anopheles gambiae str. PEST AGAP005562-PA (AgaP_AGAP005562) mRNA, complete cds K10611 RBX2, ROC2, RNF7 RING-box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10611 Q9P2J8 416 3.5e-39 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF13639//PF13465//PF12861//PF13912//PF00096//PF07776//PF00097//PF17123//PF12678 Ring finger domain//Zinc-finger double domain//Anaphase-promoting complex subunit 11 RING-H2 finger//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005634//GO:0005680 nucleus//anaphase-promoting complex -- -- Cluster-8309.52133 BP_3 25.28 2.55 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00096//PF13465 BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.52134 BP_3 84.97 4.79 1147 189240296 XP_973610.2 719 3.2e-73 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 P55158 214 4.7e-16 Microsomal triglyceride transfer protein large subunit OS=Mesocricetus auratus GN=MTTP PE=2 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52138 BP_3 25.56 0.61 2323 642922790 XP_008193326.1 883 6.2e-92 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BJD1 469 2.6e-45 Inter-alpha-trypsin inhibitor heavy chain H5 OS=Mus musculus GN=Itih5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52140 BP_3 69.13 0.80 4474 270017202 EFA13648.1 1715 4.0e-188 hypothetical protein TcasGA2_TC015886 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 184 5.5e-12 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00075//PF00589//PF05869//PF16497//PF13495 RNase H//Phage integrase family//DNA N-6-adenine-methyltransferase (Dam)//MHC-I family domain//Phage integrase, N-terminal SAM-like domain GO:0032775//GO:0006955//GO:0006310//GO:0006306//GO:0051252//GO:0015074 DNA methylation on adenine//immune response//DNA recombination//DNA methylation//regulation of RNA metabolic process//DNA integration GO:0003677//GO:0003676//GO:0009007//GO:0004523 DNA binding//nucleic acid binding//site-specific DNA-methyltransferase (adenine-specific) activity//RNA-DNA hybrid ribonuclease activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.52143 BP_3 2.00 0.55 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52144 BP_3 311.48 3.90 4143 546684929 ERL94511.1 314 1.0e-25 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF00096 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.52145 BP_3 112.90 4.93 1395 91093220 XP_967110.1 1225 8.1e-132 PREDICTED: putative Golgi pH regulator C [Tribolium castaneum]>gi|270016591|gb|EFA13037.1| hypothetical protein TcasGA2_TC010568 [Tribolium castaneum] 312070078 XM_003137932.1 38 4.68453e-08 Loa loa hypothetical protein (LOAG_02394) mRNA, partial cds -- -- -- -- B5X1G3 828 3.6e-87 Golgi pH regulator OS=Salmo salar GN=gpr89 PE=2 SV=1 PF12537 The Golgi pH Regulator (GPHR) Family N-terminal -- -- -- -- GO:0016020 membrane KOG2417 Predicted G-protein coupled receptor Cluster-8309.52146 BP_3 626.67 5.48 5807 189242051 XP_968641.2 3234 0.0e+00 PREDICTED: DNA replication licensing factor Mcm3 [Tribolium castaneum]>gi|270015933|gb|EFA12381.1| hypothetical protein TcasGA2_TC002088 [Tribolium castaneum] 752884597 XM_011261744.1 285 9.81067e-145 PREDICTED: Camponotus floridanus DNA replication licensing factor Mcm3 (LOC105253613), transcript variant X2, mRNA K02541 MCM3 DNA replication licensing factor MCM3 http://www.genome.jp/dbget-bin/www_bget?ko:K02541 Q9XYU1 2771 7.5e-312 DNA replication licensing factor Mcm3 OS=Drosophila melanogaster GN=Mcm3 PE=1 SV=1 PF07728//PF07726//PF00493 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//MCM2/3/5 family GO:0006260//GO:0006270 DNA replication//DNA replication initiation GO:0005524//GO:0003677//GO:0016887//GO:0017111 ATP binding//DNA binding//ATPase activity//nucleoside-triphosphatase activity GO:0005634 nucleus KOG0479 DNA replication licensing factor, MCM3 component Cluster-8309.52147 BP_3 16.42 0.51 1848 270015831 EFA12279.1 637 1.6e-63 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52148 BP_3 16.00 0.77 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52150 BP_3 21.00 0.87 1458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.52155 BP_3 9.00 0.66 953 369724800 AEX20235.1 1390 4.1e-151 pacifastin-related serine protease inhibitor [Portunus trituberculatus] 369724799 JF412655.1 529 0 Portunus trituberculatus pacifastin-related serine protease inhibitor mRNA, complete cds -- -- -- -- Q9NZV1 156 2.1e-09 Cysteine-rich motor neuron 1 protein OS=Homo sapiens GN=CRIM1 PE=1 SV=1 PF00093//PF05375 von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) -- -- GO:0005515//GO:0030414 protein binding//peptidase inhibitor activity -- -- -- -- Cluster-8309.52162 BP_3 251.87 6.27 2228 91091974 XP_968950.1 1097 9.0e-117 PREDICTED: protein prenyltransferase alpha subunit repeat-containing protein 1-B [Tribolium castaneum]>gi|270001151|gb|EEZ97598.1| hypothetical protein TcasGA2_TC011467 [Tribolium castaneum] -- -- -- -- -- K14137 PTAR1 protein prenyltransferase alpha subunit repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14137 A1L3L1 401 1.9e-37 Protein prenyltransferase alpha subunit repeat-containing protein 1-B (Fragment) OS=Xenopus laevis GN=ptar1-b PE=2 SV=1 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- -- -- Cluster-8309.52163 BP_3 8.00 1.84 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52164 BP_3 180.59 4.54 2211 332376709 AEE63494.1 1235 8.9e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q6QHF9 464 9.3e-45 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.52165 BP_3 5.37 0.47 837 642913083 XP_008201383.1 736 2.5e-75 PREDICTED: disks large 1 tumor suppressor protein isoform X7 [Tribolium castaneum] 642913082 XM_008203161.1 259 3.87933e-131 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X7, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 321 1.3e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.52167 BP_3 21.52 0.51 2308 478271195 ENN83593.1 916 9.1e-96 hypothetical protein YQE_00052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q924D0 442 3.4e-42 Reticulon-4-interacting protein 1, mitochondrial OS=Mus musculus GN=Rtn4ip1 PE=1 SV=2 PF00515//PF13374//PF00106//PF00107//PF13414//PF07721//PF13181//PF08240//PF00899 Tetratricopeptide repeat//Tetratricopeptide repeat//short chain dehydrogenase//Zinc-binding dehydrogenase//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Alcohol dehydrogenase GroES-like domain//ThiF family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0005515//GO:0008641//GO:0042802 oxidoreductase activity//protein binding//small protein activating enzyme activity//identical protein binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.52169 BP_3 36.81 0.87 2331 332376741 AEE63510.1 343 2.6e-29 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q29513 156 5.1e-09 Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus GN=GNMT PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52170 BP_3 57.05 0.89 3368 642911164 XP_008200608.1 2164 2.6e-240 PREDICTED: sodium/hydrogen exchanger 7 isoform X1 [Tribolium castaneum] 556959399 XM_005990356.1 38 1.14735e-07 PREDICTED: Latimeria chalumnae solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant X3, mRNA K12041 SLC9A6_7, NHE6_7 solute carrier family 9 (sodium/hydrogen exchanger), member 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K12041 Q8BLV3 1262 4.1e-137 Sodium/hydrogen exchanger 7 OS=Mus musculus GN=Slc9a7 PE=2 SV=1 PF11522//PF00999 Yeast phosphatidylinositol-4-OH kinase Pik1//Sodium/hydrogen exchanger family GO:0006812//GO:0006885//GO:0055085 cation transport//regulation of pH//transmembrane transport GO:0016773//GO:0015299 phosphotransferase activity, alcohol group as acceptor//solute:proton antiporter activity GO:0016021 integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.52171 BP_3 208.92 4.86 2364 189233838 XP_001808952.1 2559 2.8e-286 PREDICTED: sodium/hydrogen exchanger 7 isoform X2 [Tribolium castaneum] 556959399 XM_005990356.1 38 8.02226e-08 PREDICTED: Latimeria chalumnae solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant X3, mRNA K12041 SLC9A6_7, NHE6_7 solute carrier family 9 (sodium/hydrogen exchanger), member 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K12041 Q8BLV3 1370 8.7e-150 Sodium/hydrogen exchanger 7 OS=Mus musculus GN=Slc9a7 PE=2 SV=1 PF00999 Sodium/hydrogen exchanger family GO:0055085//GO:0006885//GO:0006812 transmembrane transport//regulation of pH//cation transport GO:0015299 solute:proton antiporter activity GO:0016021 integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.52173 BP_3 595.56 6.62 4625 642921981 XP_008192968.1 2946 0.0e+00 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N0W4 891 6.0e-94 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF07859//PF06330 alpha/beta hydrolase fold//Trichodiene synthase (TRI5) GO:0008152//GO:0016106//GO:0016114 metabolic process//sesquiterpenoid biosynthetic process//terpenoid biosynthetic process GO:0016787//GO:0045482 hydrolase activity//trichodiene synthase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.52174 BP_3 79.63 0.66 6116 642935532 XP_008198047.1 2202 1.8e-244 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Tribolium castaneum]>gi|270013328|gb|EFA09776.1| hypothetical protein TcasGA2_TC011918 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q14642 962 4.6e-102 Type I inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens GN=INPP5A PE=1 SV=1 -- -- GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG1976 Inositol polyphosphate 5-phosphatase, type I Cluster-8309.52178 BP_3 95.18 0.75 6422 642913900 XP_008201205.1 5196 0.0e+00 PREDICTED: anaphase-promoting complex subunit 1 [Tribolium castaneum] -- -- -- -- -- K03348 APC1 anaphase-promoting complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03348 Q9H1A4 2593 3.6e-291 Anaphase-promoting complex subunit 1 OS=Homo sapiens GN=ANAPC1 PE=1 SV=1 PF12859//PF07475 Anaphase-promoting complex subunit 1//HPr Serine kinase C-terminal domain GO:0000160//GO:0006109//GO:0016310 phosphorelay signal transduction system//regulation of carbohydrate metabolic process//phosphorylation GO:0004672//GO:0000155//GO:0005524 protein kinase activity//phosphorelay sensor kinase activity//ATP binding GO:0005680//GO:0009365 anaphase-promoting complex//protein histidine kinase complex KOG1858 Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) Cluster-8309.52179 BP_3 57.25 0.45 6416 642913900 XP_008201205.1 5580 0.0e+00 PREDICTED: anaphase-promoting complex subunit 1 [Tribolium castaneum] -- -- -- -- -- K03348 APC1 anaphase-promoting complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03348 Q9H1A4 2699 1.9e-303 Anaphase-promoting complex subunit 1 OS=Homo sapiens GN=ANAPC1 PE=1 SV=1 PF12859//PF07475 Anaphase-promoting complex subunit 1//HPr Serine kinase C-terminal domain GO:0000160//GO:0016310//GO:0006109 phosphorelay signal transduction system//phosphorylation//regulation of carbohydrate metabolic process GO:0004672//GO:0005524//GO:0000155 protein kinase activity//ATP binding//phosphorelay sensor kinase activity GO:0005680//GO:0009365 anaphase-promoting complex//protein histidine kinase complex KOG1858 Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) Cluster-8309.52181 BP_3 158.85 5.74 1625 91078370 XP_974092.1 1641 5.5e-180 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003978|gb|EFA00426.1| hypothetical protein TcasGA2_TC003280 [Tribolium castaneum] 253560541 GQ232416.1 50 1.16886e-14 Culex pipiens pipiens putative acyl-CoA dehydrogenase (ACD-1) mRNA, partial cds K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 1520 2.4e-167 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF02770//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.52183 BP_3 19.44 0.38 2756 815765826 XP_012215973.1 2839 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Linepithema humile] 752863719 XM_011269923.1 159 5.10541e-75 PREDICTED: Camponotus floridanus E3 ubiquitin-protein ligase UBR3 (LOC105258579), mRNA K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 1589 4.1e-175 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1139 Predicted ubiquitin-protein ligase of the N-recognin family Cluster-8309.52185 BP_3 368.87 10.63 1964 642918672 XP_968126.3 1009 1.3e-106 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [Tribolium castaneum] 657589840 XM_008301108.1 80 2.98393e-31 PREDICTED: Stegastes partitus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (smarce1), transcript variant X4, mRNA K11651 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11651 O54941 653 1.0e-66 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Mus musculus GN=Smarce1 PE=1 SV=1 PF01496//PF05478 V-type ATPase 116kDa subunit family//Prominin GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179//GO:0016021 proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG4715 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin Cluster-8309.52186 BP_3 49.48 1.30 2120 642918678 XP_008191535.1 810 1.6e-83 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X4 [Tribolium castaneum] 657589840 XM_008301108.1 75 1.94109e-28 PREDICTED: Stegastes partitus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (smarce1), transcript variant X4, mRNA K11651 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11651 O54941 478 2.1e-46 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Mus musculus GN=Smarce1 PE=1 SV=1 PF03938//PF05478//PF01496//PF02601 Outer membrane protein (OmpH-like)//Prominin//V-type ATPase 116kDa subunit family//Exonuclease VII, large subunit GO:0006308//GO:0015992//GO:0015991 DNA catabolic process//proton transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0051082//GO:0008855 hydrogen ion transmembrane transporter activity//unfolded protein binding//exodeoxyribonuclease VII activity GO:0009318//GO:0033179//GO:0016021 exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG4715 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin Cluster-8309.52188 BP_3 40.92 0.94 2382 817206334 XP_012279103.1 167 6.7e-09 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q [Orussus abietinus]>gi|817206336|ref|XP_012279104.1| PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q9BRB3 141 2.8e-07 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q OS=Homo sapiens GN=PIGQ PE=1 SV=3 PF05024//PF01363//PF02148//PF00641 N-acetylglucosaminyl transferase component (Gpi1)//FYVE zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//Zn-finger in Ran binding protein and others GO:0006506 GPI anchor biosynthetic process GO:0046872//GO:0008270//GO:0017176 metal ion binding//zinc ion binding//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.5219 BP_3 3.00 1.86 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52192 BP_3 7.00 2.72 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52193 BP_3 409.02 5.64 3785 91082137 XP_966595.1 1646 3.4e-180 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 172 4.17558e-82 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1351 2.2e-147 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.52194 BP_3 11.00 0.87 901 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52195 BP_3 73.00 5.85 893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52196 BP_3 31.51 0.78 2241 607368025 EZA62148.1 198 1.6e-12 THAP domain-containing protein, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52197 BP_3 119.87 1.56 3995 861619004 KMQ86923.1 990 4.1e-104 mariner transposase [Lasius niger] 689905592 LM386654.1 68 2.86859e-24 Hymenolepis diminuta genome assembly H_diminuta_Denmark ,scaffold HDID_contig0002140 -- -- -- -- Q7JQ07 390 6.4e-36 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF06056//PF11889 Putative ATPase subunit of terminase (gpP-like)//Domain of unknown function (DUF3409) GO:0006508//GO:0019069//GO:0006144 proteolysis//viral capsid assembly//purine nucleobase metabolic process GO:0003968//GO:0070008//GO:0004197//GO:0017111//GO:0004252//GO:0016817//GO:0005524 RNA-directed RNA polymerase activity//serine-type exopeptidase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//ATP binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.52198 BP_3 2.00 2.02 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52199 BP_3 109.59 1.39 4083 861619004 KMQ86923.1 756 5.8e-77 mariner transposase [Lasius niger] 689905592 LM386654.1 65 1.36429e-22 Hymenolepis diminuta genome assembly H_diminuta_Denmark ,scaffold HDID_contig0002140 K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q7JQ07 314 4.2e-27 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF05354//PF06056 Phage Head-Tail Attachment//Putative ATPase subunit of terminase (gpP-like) GO:0019069//GO:0019068 viral capsid assembly//virion assembly GO:0005524 ATP binding GO:0019028 viral capsid -- -- Cluster-8309.522 BP_3 1.00 0.85 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52201 BP_3 240.25 3.03 4112 642923805 XP_008193890.1 1839 1.5e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 8.1e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.52203 BP_3 145.16 14.21 784 642919702 XP_008192028.1 404 7.2e-37 PREDICTED: inositol-trisphosphate 3-kinase A-like [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P27987 195 5.1e-14 Inositol-trisphosphate 3-kinase B OS=Homo sapiens GN=ITPKB PE=1 SV=5 PF05456 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) GO:0045947 negative regulation of translational initiation GO:0008190 eukaryotic initiation factor 4E binding -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.52204 BP_3 45.76 0.79 3074 642911589 XP_008200663.1 795 1.3e-81 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 387 1.1e-35 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52205 BP_3 544.30 9.60 3025 642911589 XP_008200663.1 1363 1.8e-147 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 362 8.5e-33 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52207 BP_3 295.50 10.27 1679 642926835 XP_008195033.1 1501 9.7e-164 PREDICTED: cyclin-L1 [Tribolium castaneum]>gi|270009183|gb|EFA05631.1| hypothetical protein TcasGA2_TC015839 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S94 965 5.7e-103 Cyclin-L2 OS=Homo sapiens GN=CCNL2 PE=1 SV=1 PF00382//PF02984 Transcription factor TFIIB repeat//Cyclin, C-terminal domain GO:0006396//GO:0000079//GO:0006355 RNA processing//regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated GO:0017025//GO:0019901 TBP-class protein binding//protein kinase binding GO:0005634 nucleus KOG0835 Cyclin L Cluster-8309.52208 BP_3 352.01 11.80 1729 642940001 XP_008198792.1 590 4.3e-58 PREDICTED: uncharacterized protein LOC103314449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52209 BP_3 85.16 2.52 1923 642940001 XP_008198792.1 410 3.6e-37 PREDICTED: uncharacterized protein LOC103314449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52210 BP_3 312.00 20.73 1017 270003522 EEZ99969.1 283 1.0e-22 hypothetical protein TcasGA2_TC002765 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52211 BP_3 131.83 3.76 1980 642940001 XP_008198792.1 410 3.7e-37 PREDICTED: uncharacterized protein LOC103314449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52216 BP_3 9.00 0.31 1705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52217 BP_3 3.00 0.59 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5222 BP_3 1.00 0.48 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52220 BP_3 11.00 2.23 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52222 BP_3 28.00 2.62 806 668448475 KFB38130.1 158 2.5e-08 hypothetical protein ZHAS_00005405 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52223 BP_3 617.37 3.46 8883 642935083 XP_008197877.1 3815 0.0e+00 PREDICTED: calmodulin-binding transcription activator 2-like isoform X3 [Tribolium castaneum] 642935084 XM_008199656.1 481 0 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- Q9Y6Y1 651 7.7e-66 Calmodulin-binding transcription activator 1 OS=Homo sapiens GN=CAMTA1 PE=1 SV=4 PF00023//PF00612//PF01833//PF13606//PF03859//PF00899//PF10371 Ankyrin repeat//IQ calmodulin-binding motif//IPT/TIG domain//Ankyrin repeat//CG-1 domain//ThiF family//Domain of unknown function GO:0055114 oxidation-reduction process GO:0003677//GO:0016903//GO:0008641//GO:0005515 DNA binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors//small protein activating enzyme activity//protein binding GO:0005634 nucleus KOG0520 Uncharacterized conserved protein, contains IPT/TIG domain Cluster-8309.52227 BP_3 216.06 4.69 2513 332373500 AEE61891.1 743 1.1e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M882 290 1.6e-24 Ribonuclease P protein subunit p29 OS=Rattus norvegicus GN=Pop4 PE=2 SV=1 PF01868 Domain of unknown function UPF0086 GO:0051252//GO:0008033//GO:0006364//GO:0006379 regulation of RNA metabolic process//tRNA processing//rRNA processing//mRNA cleavage GO:0004540//GO:0003723 ribonuclease activity//RNA binding GO:0000172//GO:0030677 ribonuclease MRP complex//ribonuclease P complex KOG4046 RNase MRP and P, subunit POP4/p29 Cluster-8309.52228 BP_3 84.63 1.79 2573 332373500 AEE61891.1 739 3.4e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M882 290 1.6e-24 Ribonuclease P protein subunit p29 OS=Rattus norvegicus GN=Pop4 PE=2 SV=1 PF01868 Domain of unknown function UPF0086 GO:0006379//GO:0051252//GO:0008033//GO:0006364 mRNA cleavage//regulation of RNA metabolic process//tRNA processing//rRNA processing GO:0004540//GO:0003723 ribonuclease activity//RNA binding GO:0030677//GO:0000172 ribonuclease P complex//ribonuclease MRP complex KOG4046 RNase MRP and P, subunit POP4/p29 Cluster-8309.52229 BP_3 223.74 0.92 12056 642935135 XP_008197902.1 8205 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13B isoform X1 [Tribolium castaneum] -- -- -- -- -- K19526 VPS13B vacuolar protein sorting-associated protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K19526 Q80TY5 1024 5.9e-109 Vacuolar protein sorting-associated protein 13B OS=Mus musculus GN=Vps13b PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.52234 BP_3 176.20 4.49 2184 91086839 XP_974133.1 262 5.9e-20 PREDICTED: transmembrane protein 14C [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQN6 158 2.8e-09 Transmembrane protein 14C OS=Mus musculus GN=Tmem14c PE=1 SV=1 PF03647 Transmembrane proteins 14C -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.52238 BP_3 196.41 1.88 5320 642936535 XP_970405.2 5431 0.0e+00 PREDICTED: guanylate cyclase 32E [Tribolium castaneum] 642936534 XM_965312.2 763 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC658966), mRNA -- -- -- -- Q07553 2059 2.5e-229 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00069//PF02198//PF07714//PF06984//PF00211//PF07701 Protein kinase domain//Sterile alpha motif (SAM)/Pointed domain//Protein tyrosine kinase//Mitochondrial 39-S ribosomal protein L47 (MRP-L47)//Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated GO:0006144//GO:0006412//GO:0006182//GO:0006468//GO:0046039//GO:0035556//GO:0042254//GO:0009190 purine nucleobase metabolic process//translation//cGMP biosynthetic process//protein phosphorylation//GTP metabolic process//intracellular signal transduction//ribosome biogenesis//cyclic nucleotide biosynthetic process GO:0004672//GO:0016849//GO:0005524//GO:0003735//GO:0043565//GO:0004383 protein kinase activity//phosphorus-oxygen lyase activity//ATP binding//structural constituent of ribosome//sequence-specific DNA binding//guanylate cyclase activity GO:0005634//GO:0005761//GO:0005840 nucleus//mitochondrial ribosome//ribosome KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.52242 BP_3 779.99 9.45 4269 189240845 XP_001812763.1 2259 3.1e-251 PREDICTED: AP-1 complex subunit gamma-1 isoform X1 [Tribolium castaneum] 827536207 XM_004921559.2 261 1.57987e-131 PREDICTED: Bombyx mori AP-1 complex subunit gamma-1 (LOC101742239), mRNA K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 1463 2.6e-160 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF02724//PF09726//PF06213//PF02883//PF02535//PF08367//PF01080//PF04931//PF01602 CDC45-like protein//Transmembrane protein//Cobalamin biosynthesis protein CobT//Adaptin C-terminal domain//ZIP Zinc transporter//Peptidase M16C associated//Presenilin//DNA polymerase phi//Adaptin N terminal region GO:0006270//GO:0016192//GO:0006886//GO:0055085//GO:0009236//GO:0006260//GO:0006351//GO:0030001//GO:0006508 DNA replication initiation//vesicle-mediated transport//intracellular protein transport//transmembrane transport//cobalamin biosynthetic process//DNA replication//transcription, DNA-templated//metal ion transport//proteolysis GO:0003887//GO:0004190//GO:0003677//GO:0046873 DNA-directed DNA polymerase activity//aspartic-type endopeptidase activity//DNA binding//metal ion transmembrane transporter activity GO:0042575//GO:0030131//GO:0016021//GO:0030117//GO:0016020 DNA polymerase complex//clathrin adaptor complex//integral component of membrane//membrane coat//membrane KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.52245 BP_3 133.00 4.47 1726 758213862 AJO62244.1 1758 1.6e-193 chemosensory ionotropic receptor IR6 [Tenebrio molitor] 195576599 XM_002078127.1 284 1.03425e-144 Drosophila simulans GD22688 (Dsim\GD22688), mRNA K05313 GRIN glutamate receptor, ionotropic, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05313 Q9Z2W9 466 4.2e-45 Glutamate receptor 3 OS=Mus musculus GN=Gria3 PE=1 SV=2 PF08114//PF10613//PF00060 ATPase proteolipid family//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007268//GO:0007165//GO:0050790//GO:0006811 synaptic transmission//signal transduction//regulation of catalytic activity//ion transport GO:0005234//GO:0004970//GO:0030234 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//enzyme regulator activity GO:0016020 membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-8309.52246 BP_3 232.57 2.70 4442 642929566 XP_008195887.1 2710 1.7e-303 PREDICTED: uncharacterized protein LOC664242 isoform X2 [Tribolium castaneum]>gi|270009578|gb|EFA06026.1| hypothetical protein TcasGA2_TC008856 [Tribolium castaneum] 817214723 XM_012428143.1 47 1.50648e-12 PREDICTED: Orussus abietinus GTP-binding protein Rit2 (LOC105701416), partial mRNA -- -- -- -- O88667 266 1.7e-21 GTP-binding protein RAD OS=Mus musculus GN=Rrad PE=1 SV=1 PF01868//PF00498//PF08477//PF01105//PF03193//PF00025//PF00071 Domain of unknown function UPF0086//FHA domain//Ras of Complex, Roc, domain of DAPkinase//emp24/gp25L/p24 family/GOLD//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ras family GO:0007264//GO:0009987//GO:0008033//GO:0051252//GO:0006364//GO:0006810//GO:0006379 small GTPase mediated signal transduction//cellular process//tRNA processing//regulation of RNA metabolic process//rRNA processing//transport//mRNA cleavage GO:0005525//GO:0004540//GO:0005515//GO:0003924//GO:0003723 GTP binding//ribonuclease activity//protein binding//GTPase activity//RNA binding GO:0000172//GO:0016021//GO:0030677 ribonuclease MRP complex//integral component of membrane//ribonuclease P complex KOG0395 Ras-related GTPase Cluster-8309.52250 BP_3 49.01 0.50 5038 642924132 XP_008194019.1 705 5.8e-71 PREDICTED: neural-cadherin isoform X4 [Tribolium castaneum] 642924139 XM_008195802.1 222 8.93508e-110 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X8, mRNA K06803 CDH11 cadherin 11, type 2, OB-cadherin http://www.genome.jp/dbget-bin/www_bget?ko:K06803 O15943 616 5.0e-62 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF01049//PF00008 Cadherin cytoplasmic region//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.52251 BP_3 241.42 4.88 2675 727098983 AIY54303.1 1230 4.1e-132 TATA-box-binding protein [Colaphellus bowringi] 727098982 KJ534562.1 347 1.53666e-179 Colaphellus bowringi TATA-box-binding protein (TBP) mRNA, complete cds K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 P53361 1022 2.2e-109 TATA-box-binding protein OS=Spodoptera frugiperda GN=Tbp PE=2 SV=1 PF13762//PF00352//PF00560 Mitochondrial splicing apparatus component//Transcription factor TFIID (or TATA-binding protein, TBP)//Leucine Rich Repeat GO:0000372//GO:0006352 Group I intron splicing//DNA-templated transcription, initiation GO:0003677//GO:0005515 DNA binding//protein binding GO:0030529 intracellular ribonucleoprotein complex KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.52253 BP_3 27.00 1.40 1223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52254 BP_3 179.63 3.36 2871 727098983 AIY54303.1 1230 4.4e-132 TATA-box-binding protein [Colaphellus bowringi] 727098982 KJ534562.1 347 1.64965e-179 Colaphellus bowringi TATA-box-binding protein (TBP) mRNA, complete cds K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 P53361 1022 2.4e-109 TATA-box-binding protein OS=Spodoptera frugiperda GN=Tbp PE=2 SV=1 PF00560//PF00352//PF13762 Leucine Rich Repeat//Transcription factor TFIID (or TATA-binding protein, TBP)//Mitochondrial splicing apparatus component GO:0000372//GO:0006352 Group I intron splicing//DNA-templated transcription, initiation GO:0003677//GO:0005515 DNA binding//protein binding GO:0030529 intracellular ribonucleoprotein complex KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.52255 BP_3 122.11 2.77 2415 642917920 XP_008200607.1 2655 2.1e-297 PREDICTED: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [Tribolium castaneum] -- -- -- -- -- K00738 MGAT4A_B alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B http://www.genome.jp/dbget-bin/www_bget?ko:K00738 Q6GMK0 1212 1.9e-131 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B OS=Danio rerio GN=mgat4b PE=2 SV=1 PF01991//PF04666 ATP synthase (E/31 kDa) subunit//N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region GO:0005975//GO:0015992//GO:0015991//GO:0006119 carbohydrate metabolic process//proton transport//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0046961//GO:0016758 proton-transporting ATPase activity, rotational mechanism//transferase activity, transferring hexosyl groups GO:0016020//GO:0033178 membrane//proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.52258 BP_3 72.83 2.92 1494 91088311 XP_969566.1 1176 4.2e-126 PREDICTED: dipeptidase 1 [Tribolium castaneum]>gi|270012164|gb|EFA08612.1| hypothetical protein TcasGA2_TC006275 [Tribolium castaneum] -- -- -- -- -- K01273 DPEP membrane dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01273 P31430 772 1.2e-80 Dipeptidase 1 OS=Rattus norvegicus GN=Dpep1 PE=2 SV=2 PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0008238//GO:0016805 exopeptidase activity//dipeptidase activity -- -- KOG4127 Renal dipeptidase Cluster-8309.52259 BP_3 2.00 0.31 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.5226 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52260 BP_3 396.73 2.84 7017 642921434 XP_008192864.1 4129 0.0e+00 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X10 1853 2.5e-205 Ral GTPase-activating protein subunit beta OS=Homo sapiens GN=RALGAPB PE=1 SV=1 PF00237//PF02145//PF00876 Ribosomal protein L22p/L17e//Rap/ran-GAP//Innexin GO:0042254//GO:0006412//GO:0051056 ribosome biogenesis//translation//regulation of small GTPase mediated signal transduction GO:0003735//GO:0005096 structural constituent of ribosome//GTPase activator activity GO:0005840//GO:0005921 ribosome//gap junction KOG1711 Mitochondrial/chloroplast ribosomal protein L22 Cluster-8309.52263 BP_3 1499.55 13.32 5719 642920285 XP_008192283.1 1874 1.9e-206 PREDICTED: extensin-2 [Tribolium castaneum]>gi|270005272|gb|EFA01720.1| hypothetical protein TcasGA2_TC007300 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52264 BP_3 1015.45 9.07 5689 642920285 XP_008192283.1 1874 1.8e-206 PREDICTED: extensin-2 [Tribolium castaneum]>gi|270005272|gb|EFA01720.1| hypothetical protein TcasGA2_TC007300 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52270 BP_3 6.00 0.59 785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52272 BP_3 7.40 2.48 435 642918201 XP_008191408.1 422 3.3e-39 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918204 XM_008193188.1 146 1.27279e-68 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.52273 BP_3 197.75 1.05 9365 642918201 XP_008191408.1 10448 0.0e+00 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918206 XM_008193189.1 795 0 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X4, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 Q15911 1905 3.2e-211 Zinc finger homeobox protein 3 OS=Homo sapiens GN=ZFHX3 PE=1 SV=2 PF01435//PF13912//PF05920//PF13411//PF00096//PF00046//PF04988 Peptidase family M48//C2H2-type zinc finger//Homeobox KN domain//MerR HTH family regulatory protein//Zinc finger, C2H2 type//Homeobox domain//A-kinase anchoring protein 95 (AKAP95) GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0003677//GO:0004222//GO:0046872 DNA binding//metalloendopeptidase activity//metal ion binding GO:0005634 nucleus KOG1146 Homeobox protein Cluster-8309.52274 BP_3 181.40 0.98 9201 642918201 XP_008191408.1 10448 0.0e+00 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918206 XM_008193189.1 795 0 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X4, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 Q15911 1905 3.1e-211 Zinc finger homeobox protein 3 OS=Homo sapiens GN=ZFHX3 PE=1 SV=2 PF00046//PF04988//PF00096//PF05920//PF13411//PF01435//PF13912 Homeobox domain//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Homeobox KN domain//MerR HTH family regulatory protein//Peptidase family M48//C2H2-type zinc finger GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0004222//GO:0003677//GO:0046872 metalloendopeptidase activity//DNA binding//metal ion binding GO:0005634 nucleus KOG1146 Homeobox protein Cluster-8309.52277 BP_3 60.07 0.69 4488 189233937 XP_973896.2 1948 3.8e-215 PREDICTED: conserved oligomeric Golgi complex subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZHV2 925 6.6e-98 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Gallus gallus GN=NAA35 PE=2 SV=1 PF08336//PF08287//PF01442//PF02050 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Spc19//Apolipoprotein A1/A4/E domain//Flagellar FliJ protein GO:0006560//GO:0006869//GO:0071973//GO:0006935//GO:0042157//GO:0018401//GO:0006525//GO:0055114//GO:0008608 proline metabolic process//lipid transport//bacterial-type flagellum-dependent cell motility//chemotaxis//lipoprotein metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process//oxidation-reduction process//attachment of spindle microtubules to kinetochore GO:0004656//GO:0008289//GO:0003774//GO:0016702 procollagen-proline 4-dioxygenase activity//lipid binding//motor activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005783//GO:0016020//GO:0005576//GO:0005876//GO:0042729//GO:0009288 endoplasmic reticulum//membrane//extracellular region//spindle microtubule//DASH complex//bacterial-type flagellum KOG2343 Glucose-repressible protein and related proteins Cluster-8309.52278 BP_3 370.25 2.40 7716 91092128 XP_972649.1 4445 0.0e+00 PREDICTED: splicing factor 3B subunit 3 isoform X1 [Tribolium castaneum]>gi|270004662|gb|EFA01110.1| hypothetical protein TcasGA2_TC010322 [Tribolium castaneum] 77623052 CT030548.1 392 0 Xenopus tropicalis finished cDNA, clone TGas034j22 K12830 SF3B3, SAP130, RSE1 splicing factor 3B subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12830 Q15393 3985 0.0e+00 Splicing factor 3B subunit 3 OS=Homo sapiens GN=SF3B3 PE=1 SV=4 PF03178 CPSF A subunit region -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG1898 Splicing factor 3b, subunit 3 Cluster-8309.52279 BP_3 89.80 3.53 1519 478259051 ENN78994.1 2113 9.5e-235 hypothetical protein YQE_04545, partial [Dendroctonus ponderosae]>gi|546678364|gb|ERL88997.1| hypothetical protein D910_06375 [Dendroctonus ponderosae] 571531346 XM_625072.4 309 1.14945e-158 PREDICTED: Apis mellifera males absent on the first (mof), transcript variant X2, mRNA K11308 MYST1, MOF, KAT8 histone acetyltransferase MYST1 http://www.genome.jp/dbget-bin/www_bget?ko:K11308 Q9D1P2 1677 1.4e-185 Histone acetyltransferase KAT8 OS=Mus musculus GN=Kat8 PE=1 SV=1 PF01853//PF14532//PF00583//PF13508 MOZ/SAS family//Sigma-54 interaction domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967//GO:0006355 acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0008080//GO:0008134//GO:0016747//GO:0005524 N-acetyltransferase activity//transcription factor binding//transferase activity, transferring acyl groups other than amino-acyl groups//ATP binding GO:0005667 transcription factor complex KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.52280 BP_3 102.75 0.74 6955 642924674 XP_008194391.1 1323 1.8e-142 PREDICTED: protein abrupt isoform X2 [Tribolium castaneum] 642924673 XM_008196169.1 334 6.78175e-172 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X5, mRNA -- -- -- -- Q24174 633 7.4e-64 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF04135//PF13465//PF00096//PF02892//PF13912//PF00651 Nucleolar RNA-binding protein, Nop10p family//Zinc-finger double domain//Zinc finger, C2H2 type//BED zinc finger//C2H2-type zinc finger//BTB/POZ domain GO:0001522//GO:0042254 pseudouridine synthesis//ribosome biogenesis GO:0030515//GO:0003677//GO:0046872//GO:0005515 snoRNA binding//DNA binding//metal ion binding//protein binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.52281 BP_3 51.91 0.88 3124 642928964 XP_008195636.1 452 7.9e-42 PREDICTED: uncharacterized protein LOC103313636 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52282 BP_3 44.54 1.15 2163 795011494 XP_011872774.1 309 2.1e-25 PREDICTED: uncharacterized protein LOC105564750, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.52284 BP_3 5.00 0.74 619 642927016 XP_008195104.1 408 2.0e-37 PREDICTED: ATP-binding cassette sub-family A member 2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 P41233 256 3.4e-21 ATP-binding cassette sub-family A member 1 OS=Mus musculus GN=Abca1 PE=1 SV=4 PF13304//PF06414//PF03193//PF04310//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//Protein of unknown function, DUF258//MukB N-terminal//ABC transporter GO:0007059//GO:0030261 chromosome segregation//chromosome condensation GO:0005525//GO:0016301//GO:0016887//GO:0003924//GO:0005524//GO:0003677 GTP binding//kinase activity//ATPase activity//GTPase activity//ATP binding//DNA binding GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52286 BP_3 107.88 1.48 3797 478249703 ENN70211.1 1542 3.9e-168 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 617 2.9e-62 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF00005//PF13304//PF03152 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//Ubiquitin fusion degradation protein UFD1 GO:0006511 ubiquitin-dependent protein catabolic process GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52288 BP_3 25.12 0.33 3959 478249703 ENN70211.1 1603 3.4e-175 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 628 1.6e-63 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF13304//PF00005//PF03152 AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Ubiquitin fusion degradation protein UFD1 GO:0006511 ubiquitin-dependent protein catabolic process GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52290 BP_3 2.00 0.60 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52291 BP_3 223.99 2.48 4638 189236877 XP_974696.2 4794 0.0e+00 PREDICTED: exportin-5 [Tribolium castaneum] -- -- -- -- -- K14289 XPO5 exportin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K14289 Q9HAV4 1864 8.9e-207 Exportin-5 OS=Homo sapiens GN=XPO5 PE=1 SV=1 PF03810//PF00822//PF05236 Importin-beta N-terminal domain//PMP-22/EMP/MP20/Claudin family//Transcription initiation factor TFIID component TAF4 family GO:0006886//GO:0006352 intracellular protein transport//DNA-templated transcription, initiation GO:0008536 Ran GTPase binding GO:0005669//GO:0016021 transcription factor TFIID complex//integral component of membrane KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.52292 BP_3 246.84 3.44 3750 189236877 XP_974696.2 4119 0.0e+00 PREDICTED: exportin-5 [Tribolium castaneum] -- -- -- -- -- K14289 XPO5 exportin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K14289 Q9HAV4 1527 8.6e-168 Exportin-5 OS=Homo sapiens GN=XPO5 PE=1 SV=1 PF05236//PF00822//PF03810 Transcription initiation factor TFIID component TAF4 family//PMP-22/EMP/MP20/Claudin family//Importin-beta N-terminal domain GO:0006352//GO:0006886 DNA-templated transcription, initiation//intracellular protein transport GO:0008536 Ran GTPase binding GO:0005669//GO:0016021 transcription factor TFIID complex//integral component of membrane KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.52293 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52295 BP_3 1613.62 10.10 7994 478259801 ENN79629.1 3189 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.14606e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.7e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433//PF00443 Peptidase family M1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0008270//GO:0008237 ubiquitinyl hydrolase activity//zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.52297 BP_3 18.65 0.39 2591 642919246 XP_008191792.1 872 1.3e-90 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 509 6.6e-50 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.52298 BP_3 175.47 2.64 3493 546685251 ERL94778.1 1443 1.1e-156 hypothetical protein D910_12052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2Q2 261 5.1e-21 FERM domain-containing protein 4A OS=Homo sapiens GN=FRMD4A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52299 BP_3 81.83 1.80 2478 91088919 XP_973208.1 1960 8.5e-217 PREDICTED: protein asunder [Tribolium castaneum]>gi|270012357|gb|EFA08805.1| hypothetical protein TcasGA2_TC006499 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8QZV7 1003 3.3e-107 Protein asunder homolog OS=Mus musculus GN=Asun PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3711 Uncharacterized conserved protein Cluster-8309.52301 BP_3 746.59 7.33 5204 91083631 XP_970382.1 3673 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 2.07024e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2881 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF00107//PF00236//PF00005//PF02233//PF02456//PF03188//PF02826//PF01752//PF00205 Zinc-binding dehydrogenase//Glycoprotein hormone//ABC transporter//NAD(P) transhydrogenase beta subunit//Adenovirus IVa2 protein//Eukaryotic cytochrome b561//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Collagenase//Thiamine pyrophosphate enzyme, central domain GO:0007165//GO:0019083//GO:0046497//GO:0015992//GO:0006769//GO:0055114//GO:0006508 signal transduction//viral transcription//nicotinate nucleotide metabolic process//proton transport//nicotinamide metabolic process//oxidation-reduction process//proteolysis GO:0005524//GO:0008750//GO:0008270//GO:0016887//GO:0004252//GO:0050661//GO:0005179//GO:0051287//GO:0000287//GO:0030976 ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//zinc ion binding//ATPase activity//serine-type endopeptidase activity//NADP binding//hormone activity//NAD binding//magnesium ion binding//thiamine pyrophosphate binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.52304 BP_3 91.78 1.10 4313 642923817 XP_001816010.2 2807 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 1.64211e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q9NQC7 1004 4.4e-107 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens GN=CYLD PE=1 SV=1 PF00443//PF07297//PF04451//PF01529 Ubiquitin carboxyl-terminal hydrolase//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Large eukaryotic DNA virus major capsid protein//DHHC palmitoyltransferase GO:0009059//GO:0016579 macromolecule biosynthetic process//protein deubiquitination GO:0008270//GO:0036459//GO:0005198 zinc ion binding//ubiquitinyl hydrolase activity//structural molecule activity GO:0019028//GO:0030176 viral capsid//integral component of endoplasmic reticulum membrane KOG2257 N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis Cluster-8309.52308 BP_3 10.00 0.49 1273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52309 BP_3 4.26 0.38 839 642912070 XP_008200786.1 442 3.0e-41 PREDICTED: peroxidase isoform X2 [Tribolium castaneum]>gi|642912072|ref|XP_008200787.1| PREDICTED: peroxidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q01603 262 9.3e-22 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.52313 BP_3 561.03 9.72 3073 642926822 XP_008195028.1 2091 6.8e-232 PREDICTED: pre-mRNA-processing factor 40 homolog A [Tribolium castaneum]>gi|270009175|gb|EFA05623.1| hypothetical protein TcasGA2_TC015831 [Tribolium castaneum] 642926821 XM_008196806.1 308 8.45791e-158 PREDICTED: Tribolium castaneum pre-mRNA-processing factor 40 homolog A (LOC658510), mRNA K12821 PRPF40, PRP40 pre-mRNA-processing factor 40 http://www.genome.jp/dbget-bin/www_bget?ko:K12821 Q6NWY9 1231 1.5e-133 Pre-mRNA-processing factor 40 homolog B OS=Homo sapiens GN=PRPF40B PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0152 Spliceosomal protein FBP11/Splicing factor PRP40 Cluster-8309.52316 BP_3 12.00 1.25 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52318 BP_3 9.00 0.82 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52320 BP_3 6.00 9.70 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52323 BP_3 63.31 3.16 1258 780633762 XP_011686120.1 143 2.1e-06 PREDICTED: uncharacterized protein LOC105448935 isoform X1 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52325 BP_3 4.00 11.50 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52326 BP_3 11.69 0.59 1242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52331 BP_3 167.95 1.04 8104 642931705 XP_008196694.1 3379 0.0e+00 PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum]>gi|642931707|ref|XP_008196695.1| PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum] -- -- -- -- -- K06640 ATR serine/threonine-protein kinase ATR http://www.genome.jp/dbget-bin/www_bget?ko:K06640 Q13535 1889 2.0e-209 Serine/threonine-protein kinase ATR OS=Homo sapiens GN=ATR PE=1 SV=3 PF08064//PF02259//PF00454//PF02260 UME (NUC010) domain//FAT domain//Phosphatidylinositol 3- and 4-kinase//FATC domain GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0005515//GO:0016773 protein serine/threonine kinase activity//protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0890 Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination Cluster-8309.52332 BP_3 248.12 9.78 1515 642926073 XP_008194754.1 280 3.3e-22 PREDICTED: E3 ubiquitin-protein ligase RNF8-B-like [Tribolium castaneum]>gi|270008553|gb|EFA05001.1| hypothetical protein TcasGA2_TC015080 [Tribolium castaneum] -- -- -- -- -- K10667 RNF8 E3 ubiquitin-protein ligase RNF8 http://www.genome.jp/dbget-bin/www_bget?ko:K10667 Q2HJ46 264 9.9e-22 E3 ubiquitin-protein ligase RNF8 OS=Bos taurus GN=RNF8 PE=2 SV=1 PF04564//PF14634//PF12678//PF00498//PF00097//PF16685//PF13639//PF12861 U-box domain//zinc-RING finger domain//RING-H2 zinc finger//FHA domain//Zinc finger, C3HC4 type (RING finger)//zinc RING finger of MSL2//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0061630//GO:0004842//GO:0005515//GO:0008270//GO:0043169//GO:0046872 ubiquitin protein ligase activity//ubiquitin-protein transferase activity//protein binding//zinc ion binding//cation binding//metal ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.52333 BP_3 29.84 0.98 1753 765160702 XP_011489848.1 269 7.3e-21 PREDICTED: E3 ubiquitin-protein ligase RNF8 isoform X4 [Oryzias latipes] -- -- -- -- -- K10667 RNF8 E3 ubiquitin-protein ligase RNF8 http://www.genome.jp/dbget-bin/www_bget?ko:K10667 Q2HJ46 261 2.5e-21 E3 ubiquitin-protein ligase RNF8 OS=Bos taurus GN=RNF8 PE=2 SV=1 PF13639//PF16685//PF12861//PF00097//PF00498//PF12678//PF17123//PF04564//PF14634 Ring finger domain//zinc RING finger of MSL2//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger)//FHA domain//RING-H2 zinc finger//RING-like zinc finger//U-box domain//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0061630//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//ubiquitin protein ligase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.52335 BP_3 82.98 20.25 489 546678005 ERL88729.1 701 1.6e-71 hypothetical protein D910_06111 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9UKZ1 617 3.7e-63 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52338 BP_3 14.00 0.35 2201 -- -- -- -- -- 642913296 XM_970406.2 58 5.68653e-19 PREDICTED: Tribolium castaneum vesicular acetylcholine transporter (LOC664399), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52341 BP_3 38.52 0.59 3427 357621647 EHJ73416.1 189 2.7e-11 putative pol-like protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00075//PF02723 RNase H//Non-structural protein NS3/Small envelope protein E GO:0051252 regulation of RNA metabolic process GO:0003676//GO:0004523 nucleic acid binding//RNA-DNA hybrid ribonuclease activity GO:0016020 membrane -- -- Cluster-8309.52344 BP_3 1364.00 12.76 5445 642919210 XP_008191781.1 5464 0.0e+00 PREDICTED: uncharacterized protein LOC657327 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00530//PF15494//PF09272 Scavenger receptor cysteine-rich domain//Scavenger receptor cysteine-rich domain//Hepsin, SRCR GO:0007165 signal transduction GO:0004252//GO:0070008//GO:0005044 serine-type endopeptidase activity//serine-type exopeptidase activity//scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.52345 BP_3 251.51 3.53 3726 642923662 XP_008193832.1 4111 0.0e+00 PREDICTED: protein phosphatase PHLPP-like protein [Tribolium castaneum] 642923661 XM_008195610.1 421 0 PREDICTED: Tribolium castaneum protein phosphatase PHLPP-like protein (LOC662191), mRNA K16340 PHLPP PH domain and leucine-rich repeat-containing protein phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16340 Q9VJ07 1138 1.1e-122 Protein phosphatase PHLPP-like protein OS=Drosophila melanogaster GN=Phlpp PE=3 SV=1 PF00560//PF00481//PF13855 Leucine Rich Repeat//Protein phosphatase 2C//Leucine rich repeat -- -- GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG0618 Serine/threonine phosphatase 2C containing leucine-rich repeats, similar to SCN circadian oscillatory protein (SCOP) Cluster-8309.52346 BP_3 889.49 12.54 3710 642923662 XP_008193832.1 4367 0.0e+00 PREDICTED: protein phosphatase PHLPP-like protein [Tribolium castaneum] 642923661 XM_008195610.1 432 0 PREDICTED: Tribolium castaneum protein phosphatase PHLPP-like protein (LOC662191), mRNA K16340 PHLPP PH domain and leucine-rich repeat-containing protein phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16340 Q9VJ07 1138 1.1e-122 Protein phosphatase PHLPP-like protein OS=Drosophila melanogaster GN=Phlpp PE=3 SV=1 PF00481//PF00560//PF13855 Protein phosphatase 2C//Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515//GO:0003824 protein binding//catalytic activity -- -- KOG0618 Serine/threonine phosphatase 2C containing leucine-rich repeats, similar to SCN circadian oscillatory protein (SCOP) Cluster-8309.52350 BP_3 5.93 0.42 979 270006792 EFA03240.1 256 1.3e-19 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZA47 217 1.8e-16 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.52352 BP_3 128.33 6.74 1210 332375232 AEE62757.1 903 1.5e-94 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00729 ALG5 dolichyl-phosphate beta-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00729 Q9VLQ1 711 1.2e-73 Dolichyl-phosphate beta-glucosyltransferase OS=Drosophila melanogaster GN=wol PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2977 Glycosyltransferase Cluster-8309.52353 BP_3 46.41 0.56 4302 688550711 XP_009299041.1 812 1.9e-83 PREDICTED: gastrula zinc finger protein XlCGF57.1-like, partial [Danio rerio] -- -- -- -- -- -- -- -- -- P52742 790 2.9e-82 Zinc finger protein 135 OS=Homo sapiens GN=ZNF135 PE=2 SV=3 PF00096//PF02178//PF13465//PF07776//PF16622//PF13912 Zinc finger, C2H2 type//AT hook motif//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.52355 BP_3 139.00 3.51 2199 741829513 AJA91072.1 1659 6.1e-182 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 1063 3.2e-114 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067//PF15681//PF09298 Cytochrome P450//Lymphocyte activation family X//Fumarylacetoacetase N-terminal GO:0006570//GO:0055114//GO:0042207//GO:0006955//GO:0051249//GO:0009072 tyrosine metabolic process//oxidation-reduction process//styrene catabolic process//immune response//regulation of lymphocyte activation//aromatic amino acid family metabolic process GO:0016705//GO:0004334//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//fumarylacetoacetase activity//iron ion binding//heme binding -- -- -- -- Cluster-8309.52358 BP_3 4.68 1.29 466 642937507 XP_008198870.1 220 9.3e-16 PREDICTED: protein tramtrack, beta isoform-like isoform X30 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52361 BP_3 4.00 1.70 404 357622556 EHJ73984.1 218 1.4e-15 eIF2B-alpha protein [Danaus plexippus] -- -- -- -- -- K03239 EIF2B1 translation initiation factor eIF-2B subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03239 Q99LC8 184 5.0e-13 Translation initiation factor eIF-2B subunit alpha OS=Mus musculus GN=Eif2b1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) Cluster-8309.52362 BP_3 22.90 0.34 3525 642921224 XP_008192769.1 1907 1.7e-210 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921235 XM_008194553.1 272 9.9956e-138 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 651 3.1e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF00018//PF14604//PF00023//PF13606//PF00788 SH3 domain//Variant SH3 domain//Ankyrin repeat//Ankyrin repeat//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.52363 BP_3 129.92 12.67 786 759035214 XP_011338260.1 142 1.7e-06 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105279872 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52364 BP_3 14.74 1.00 1000 755948394 XP_011300766.1 1018 5.9e-108 PREDICTED: ryanodine receptor 44F isoform X9 [Fopius arisanus] 194752972 XM_001958757.1 275 5.95205e-140 Drosophila ananassae GF12384 (Dana\GF12384), mRNA K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 1016 4.1e-109 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.52365 BP_3 23.47 0.35 3503 411147305 BAM66322.1 2031 7.1e-225 GABA-gated chloride channel [Oulema oryzae] 584463066 KC288141.2 762 0 Diabrotica virgifera virgifera GABA receptor mRNA, complete cds K05195 GLRA3 glycine receptor alpha-3 http://www.genome.jp/dbget-bin/www_bget?ko:K05195 Q75NA5 1805 4.7e-200 Gamma-aminobutyric acid receptor subunit beta OS=Musca domestica GN=Rdl PE=1 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3643 GABA receptor Cluster-8309.52366 BP_3 40.20 0.81 2676 300807184 NP_001180223.1 1572 9.1e-172 juvenile hormone esterase precursor [Tribolium castaneum]>gi|300117035|dbj|BAJ10675.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117037|dbj|BAJ10676.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117039|dbj|BAJ10677.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117041|dbj|BAJ10678.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117043|dbj|BAJ10679.1| juvenile hormone esterase [Tribolium castaneum] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 712 2.0e-73 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.52368 BP_3 46.24 1.12 2279 17646748 AAL41023.1 932 1.3e-97 juvenile hormone esterase [Tenebrio molitor] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 P35502 494 3.2e-48 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.52373 BP_3 130.43 14.12 737 91090888 XP_973381.1 1122 3.8e-120 PREDICTED: YEATS domain-containing protein 4 [Tribolium castaneum]>gi|270014003|gb|EFA10451.1| hypothetical protein TcasGA2_TC012697 [Tribolium castaneum] 571562276 XM_396159.3 137 2.2409e-63 PREDICTED: Apis mellifera YEATS domain-containing protein 4 (Gas41), transcript variant X2, mRNA K11341 YEATS4, GAS41, YAF9 YEATS domain-containing protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11341 O95619 762 8.6e-80 YEATS domain-containing protein 4 OS=Homo sapiens GN=YEATS4 PE=1 SV=1 PF03366//PF07544 YEATS family//RNA polymerase II transcription mediator complex subunit 9 GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592 nucleus//mediator complex KOG3149 Transcription initiation factor IIF, auxiliary subunit Cluster-8309.52377 BP_3 33.72 0.87 2167 642922696 XP_008193284.1 873 8.3e-91 PREDICTED: succinate--hydroxymethylglutarate CoA-transferase [Tribolium castaneum] -- -- -- -- -- K18703 SUGCT succinate---hydroxymethylglutarate CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18703 Q7TNE1 620 7.4e-63 Succinate--hydroxymethylglutarate CoA-transferase OS=Mus musculus GN=Sugct PE=1 SV=2 PF02515 CoA-transferase family III -- -- GO:0003824 catalytic activity -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.52378 BP_3 55.70 1.52 2053 642922696 XP_008193284.1 1638 1.5e-179 PREDICTED: succinate--hydroxymethylglutarate CoA-transferase [Tribolium castaneum] -- -- -- -- -- K18703 SUGCT succinate---hydroxymethylglutarate CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18703 Q7TNE1 1143 1.6e-123 Succinate--hydroxymethylglutarate CoA-transferase OS=Mus musculus GN=Sugct PE=1 SV=2 PF02515 CoA-transferase family III -- -- GO:0003824 catalytic activity -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.52380 BP_3 50.90 0.31 8129 642916033 XP_008190864.1 1601 1.2e-174 PREDICTED: lisH domain and HEAT repeat-containing protein KIAA1468 homolog [Tribolium castaneum]>gi|270003733|gb|EFA00181.1| hypothetical protein TcasGA2_TC003006 [Tribolium castaneum] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q99489 534 2.6e-52 D-aspartate oxidase OS=Homo sapiens GN=DDO PE=2 SV=1 PF12179//PF06156//PF02985//PF01266 I-kappa-kinase-beta NEMO binding domain//Protein of unknown function (DUF972)//HEAT repeat//FAD dependent oxidoreductase GO:0009069//GO:0016310//GO:0006260//GO:0055114 serine family amino acid metabolic process//phosphorylation//DNA replication//oxidation-reduction process GO:0005515//GO:0016491//GO:0008384 protein binding//oxidoreductase activity//IkappaB kinase activity GO:0008385 IkappaB kinase complex KOG3923 D-aspartate oxidase Cluster-8309.52381 BP_3 501.79 7.28 3612 546674389 ERL85776.1 3682 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 642926086 XM_001808290.2 491 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase TAO1 (LOC657810), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 O88664 1304 6.0e-142 Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus GN=Taok1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.52383 BP_3 32.74 0.39 4338 642911921 XP_008199023.1 325 5.8e-27 PREDICTED: casein kinase I isoform gamma-3-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q9Y6M4 177 3.5e-11 Casein kinase I isoform gamma-3 OS=Homo sapiens GN=CSNK1G3 PE=1 SV=2 PF02184 HAT (Half-A-TPR) repeat GO:0006396 RNA processing -- -- GO:0005622 intracellular -- -- Cluster-8309.52384 BP_3 148.36 1.78 4319 270014464 EFA10912.1 878 4.3e-91 hypothetical protein TcasGA2_TC001738 [Tribolium castaneum] 805771597 XM_012281305.1 102 3.90243e-43 PREDICTED: Megachile rotundata casein kinase I isoform gamma-3 (LOC100876501), transcript variant X6, mRNA K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q8C4X2 724 1.3e-74 Casein kinase I isoform gamma-3 OS=Mus musculus GN=Csnk1g3 PE=1 SV=2 PF12605//PF02184//PF00069 Casein kinase 1 gamma C terminal//HAT (Half-A-TPR) repeat//Protein kinase domain GO:0006396//GO:0009069//GO:0006468//GO:0016310 RNA processing//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004674//GO:0004672//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0005622 intracellular KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.52385 BP_3 1354.36 17.57 4007 642911919 XP_008199022.1 2018 2.6e-223 PREDICTED: casein kinase I isoform gamma-3-like isoform X2 [Tribolium castaneum] 805771594 XM_012281304.1 194 2.60597e-94 PREDICTED: Megachile rotundata casein kinase I isoform gamma-3 (LOC100876501), transcript variant X5, mRNA K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q62763 1546 5.8e-170 Casein kinase I isoform gamma-3 OS=Rattus norvegicus GN=Csnk1g3 PE=2 SV=1 PF00069//PF02184//PF07714//PF12605 Protein kinase domain//HAT (Half-A-TPR) repeat//Protein tyrosine kinase//Casein kinase 1 gamma C terminal GO:0006396//GO:0016310//GO:0009069//GO:0006468 RNA processing//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0005622 intracellular KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.52388 BP_3 63.66 0.86 3874 -- -- -- -- -- 301173032 NR_036303.1 37 4.75327e-07 Tribolium castaneum microRNA mir-277 (Mir277), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52396 BP_3 38.82 0.62 3296 642928315 XP_008195531.1 965 2.7e-101 PREDICTED: microtubule-associated protein RP/EB family member 1 [Tribolium castaneum] 389608702 AK401339.1 148 7.9716e-69 Papilio xuthus mRNA for microtubule binding protein, putative, complete cds, sequence id: Px-0417 K10436 MAPRE microtubule-associated protein, RP/EB family http://www.genome.jp/dbget-bin/www_bget?ko:K10436 Q6P848 756 1.9e-78 Microtubule-associated protein RP/EB family member 1 OS=Xenopus tropicalis GN=mapre1 PE=2 SV=1 PF06070//PF00307//PF03271//PF05361 Herpesvirus large structural phosphoprotein UL32//Calponin homology (CH) domain//EB1-like C-terminal motif//PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation GO:0005198//GO:0005515//GO:0008017 structural molecule activity//protein binding//microtubule binding GO:0005737//GO:0045298 cytoplasm//tubulin complex KOG3000 Microtubule-binding protein involved in cell cycle control Cluster-8309.52398 BP_3 21.02 1.13 1188 194754345 XP_001959456.1 143 2.0e-06 GF12046 [Drosophila ananassae]>gi|190620754|gb|EDV36278.1| GF12046 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04487//PF01155 CITED//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006355//GO:0006464 regulation of transcription, DNA-templated//cellular protein modification process GO:0016151 nickel cation binding GO:0005634 nucleus -- -- Cluster-8309.52402 BP_3 617.24 6.88 4615 642923551 XP_008193555.1 837 2.6e-86 PREDICTED: Golgi integral membrane protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49638 186 3.3e-12 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 PF05090//PF04111//PF02566//PF01940//PF02513 Vitamin K-dependent gamma-carboxylase//Autophagy protein Apg6//OsmC-like protein//Integral membrane protein DUF92//Spin/Ssty Family GO:0007276//GO:0006979//GO:0017187//GO:0006914 gamete generation//response to oxidative stress//peptidyl-glutamic acid carboxylation//autophagy GO:0008488 gamma-glutamyl carboxylase activity GO:0016021 integral component of membrane -- -- Cluster-8309.52405 BP_3 562.97 5.49 5238 642928819 XP_008195574.1 1389 2.9e-150 PREDICTED: transcriptional repressor p66-alpha isoform X1 [Tribolium castaneum] 642928820 XM_008197353.1 64 6.30726e-22 PREDICTED: Tribolium castaneum transcriptional repressor p66-alpha (LOC656529), transcript variant X2, mRNA -- -- -- -- Q8VHR5 344 1.8e-30 Transcriptional repressor p66-beta OS=Mus musculus GN=Gatad2b PE=1 SV=1 PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.52407 BP_3 71.05 2.39 1724 642936590 XP_008198497.1 809 1.7e-83 PREDICTED: uncharacterized protein LOC103314369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52409 BP_3 69.97 2.41 1690 642923832 XP_008193898.1 2202 5.1e-245 PREDICTED: importin subunit alpha-4 [Tribolium castaneum] 170029938 XM_001842796.1 194 1.08643e-94 Culex quinquefasciatus importin alpha, mRNA -- -- -- -- O35343 1804 2.9e-200 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 PF01749//PF02985//PF01602//PF11698//PF00514 Importin beta binding domain//HEAT repeat//Adaptin N terminal region//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0015031//GO:0006606//GO:0016192//GO:0006886//GO:0015991 protein transport//protein import into nucleus//vesicle-mediated transport//intracellular protein transport//ATP hydrolysis coupled proton transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0005737//GO:0000221//GO:0005634 membrane coat//cytoplasm//vacuolar proton-transporting V-type ATPase, V1 domain//nucleus KOG0166 Karyopherin (importin) alpha Cluster-8309.52410 BP_3 44.54 0.70 3372 270007768 EFA04216.1 1199 2.0e-128 hypothetical protein TcasGA2_TC014465 [Tribolium castaneum] 170029938 XM_001842796.1 262 3.46181e-132 Culex quinquefasciatus importin alpha, mRNA -- -- -- -- O35343 981 1.6e-104 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 PF11698//PF00514//PF01602//PF02985//PF01749//PF11538//PF10508 V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//HEAT repeat//Importin beta binding domain//Snurportin1//Proteasome non-ATPase 26S subunit GO:0043248//GO:0006606//GO:0015031//GO:0015991//GO:0006886//GO:0016192 proteasome assembly//protein import into nucleus//protein transport//ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle-mediated transport GO:0008565//GO:0016820//GO:0005515 protein transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0005737//GO:0030117//GO:0005634//GO:0000221 cytoplasm//membrane coat//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain KOG0166 Karyopherin (importin) alpha Cluster-8309.52412 BP_3 5.00 1.45 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52413 BP_3 44.84 0.51 4569 817074162 XP_012259260.1 369 4.8e-32 PREDICTED: uncharacterized protein LOC105687895 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52414 BP_3 145.26 1.43 5177 817074162 XP_012259260.1 369 5.5e-32 PREDICTED: uncharacterized protein LOC105687895 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52415 BP_3 11.23 0.38 1701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52416 BP_3 36.24 0.36 5083 817074162 XP_012259260.1 369 5.4e-32 PREDICTED: uncharacterized protein LOC105687895 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52419 BP_3 190.50 1.78 5440 642917556 XP_008191255.1 3201 0.0e+00 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.80891e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 257 2.3e-20 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.5242 BP_3 7.84 1.34 573 -- -- -- -- -- 301173163 NR_036317.1 74 1.80536e-28 Tribolium castaneum microRNA bantam (bantam), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52420 BP_3 248.53 1.37 9063 270015570 EFA12018.1 4146 0.0e+00 hypothetical protein TcasGA2_TC001433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86YS7 1257 4.2e-136 C2 domain-containing protein 5 OS=Homo sapiens GN=C2CD5 PE=1 SV=1 PF00168//PF08354 C2 domain//Domain of unknown function (DUF1729) GO:0042967//GO:0055114//GO:0006633 acyl-carrier-protein biosynthetic process//oxidation-reduction process//fatty acid biosynthetic process GO:0005515//GO:0004318 protein binding//enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0005835 fatty acid synthase complex KOG1031 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.52423 BP_3 2.00 1.46 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52424 BP_3 59.63 1.94 1775 478256893 ENN77062.1 359 2.7e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 2.8e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF13912//PF07975//PF00096//PF13465 C2H2-type zinc finger//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.52428 BP_3 67.80 1.05 3398 189233571 XP_967872.2 671 3.4e-67 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96B67 190 8.4e-13 Arrestin domain-containing protein 3 OS=Homo sapiens GN=ARRDC3 PE=1 SV=1 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0051287 NAD binding -- -- -- -- Cluster-8309.52430 BP_3 81.12 0.72 5734 189233571 XP_967872.2 668 1.3e-66 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96B67 193 6.4e-13 Arrestin domain-containing protein 3 OS=Homo sapiens GN=ARRDC3 PE=1 SV=1 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0051287 NAD binding -- -- -- -- Cluster-8309.52434 BP_3 165.84 2.61 3353 189234241 XP_976116.2 354 1.9e-30 PREDICTED: high affinity copper uptake protein 1 isoform X2 [Tribolium castaneum] 194896366 XM_001978429.1 74 1.11032e-27 Drosophila erecta GG19602 (Dere\GG19602), mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 262 3.7e-21 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145//PF06305 Ctr copper transporter family//Protein of unknown function (DUF1049) GO:0035434//GO:0006825 copper ion transmembrane transport//copper ion transport GO:0005375 copper ion transmembrane transporter activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane KOG3386 Copper transporter Cluster-8309.52436 BP_3 127.52 1.75 3798 270011590 EFA08038.1 2324 8.1e-259 hypothetical protein TcasGA2_TC005627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ET47 433 6.3e-41 Espin OS=Mus musculus GN=Espn PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52437 BP_3 302.43 3.01 5131 270011590 EFA08038.1 2616 1.5e-292 hypothetical protein TcasGA2_TC005627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ET47 433 8.5e-41 Espin OS=Mus musculus GN=Espn PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52438 BP_3 1350.07 15.21 4571 270011590 EFA08038.1 2616 1.3e-292 hypothetical protein TcasGA2_TC005627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ET47 434 5.8e-41 Espin OS=Mus musculus GN=Espn PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52439 BP_3 112.79 3.02 2093 642914172 XP_008201574.1 1882 8.0e-208 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 954 1.3e-101 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF01738 Dienelactone hydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.5244 BP_3 14.20 0.49 1691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52442 BP_3 1.00 0.61 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52446 BP_3 16.00 1.00 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52447 BP_3 32.00 3.34 754 746849727 XP_011055317.1 270 2.4e-21 PREDICTED: uncharacterized protein LOC105146626 isoform X1 [Acromyrmex echinatior]>gi|746849729|ref|XP_011055318.1| PREDICTED: uncharacterized protein LOC105146626 isoform X2 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52448 BP_3 30.00 1.49 1262 847114225 XP_012815396.1 145 1.3e-06 PREDICTED: uncharacterized protein LOC105946840 [Xenopus (Silurana) tropicalis]>gi|847114228|ref|XP_012815397.1| PREDICTED: uncharacterized protein LOC105946840 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07850//PF04218 Renin receptor-like protein//CENP-B N-terminal DNA-binding domain GO:0007165 signal transduction GO:0004872//GO:0003677 receptor activity//DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.52449 BP_3 35.45 0.90 2184 546677792 ERL88559.1 1875 5.4e-207 hypothetical protein D910_05944 [Dendroctonus ponderosae] -- -- -- -- -- K13174 THOC5 THO complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13174 Q6NY52 901 1.9e-95 THO complex subunit 5 homolog OS=Danio rerio GN=thoc5 PE=2 SV=1 PF05225//PF05773 helix-turn-helix, Psq domain//RWD domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG2216 Conserved coiled/coiled coil protein Cluster-8309.52451 BP_3 12.00 0.39 1790 196012373 XP_002116049.1 583 2.9e-57 expressed hypothetical protein [Trichoplax adhaerens]>gi|190581372|gb|EDV21449.1| expressed hypothetical protein [Trichoplax adhaerens] 768311753 CP010981.1 1760 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- P32465 1074 1.4e-115 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 PF00083//PF07690//PF08264 Sugar (and other) transporter//Major Facilitator Superfamily//Anticodon-binding domain of tRNA GO:0055085//GO:0006418 transmembrane transport//tRNA aminoacylation for protein translation GO:0000166//GO:0022857 nucleotide binding//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.52454 BP_3 365.19 1.76 10317 642914930 XP_008190446.1 6655 0.0e+00 PREDICTED: protein slit isoform X3 [Tribolium castaneum] 462424845 APGK01016975.1 99 4.35647e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 5055 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF13639//PF13855//PF07645//PF00008//PF14634//PF00560//PF00097 Ring finger domain//Leucine rich repeat//Calcium-binding EGF domain//EGF-like domain//zinc-RING finger domain//Leucine Rich Repeat//Zinc finger, C3HC4 type (RING finger) -- -- GO:0046872//GO:0005515//GO:0005509//GO:0008270 metal ion binding//protein binding//calcium ion binding//zinc ion binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.52456 BP_3 558.92 2.66 10407 642914926 XP_008190444.1 6829 0.0e+00 PREDICTED: protein slit isoform X1 [Tribolium castaneum] 462424845 APGK01016975.1 99 4.39461e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 5191 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF07645//PF00008//PF14634//PF00560//PF00097//PF13639//PF13855 Calcium-binding EGF domain//EGF-like domain//zinc-RING finger domain//Leucine Rich Repeat//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Leucine rich repeat -- -- GO:0005515//GO:0046872//GO:0008270//GO:0005509 protein binding//metal ion binding//zinc ion binding//calcium ion binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.52458 BP_3 12.00 0.69 1135 642935245 XP_008197928.1 315 2.2e-26 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS29 141 1.4e-07 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52459 BP_3 6.00 0.87 625 198456023 XP_001360206.2 249 5.4e-19 dscam [Drosophila pseudoobscura pseudoobscura]>gi|198135489|gb|EAL24780.2| dscam [Drosophila pseudoobscura pseudoobscura] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52462 BP_3 15.29 0.33 2512 642921806 XP_008199327.1 236 7.0e-17 PREDICTED: uncharacterized protein LOC103314630 isoform X2 [Tribolium castaneum]>gi|270008091|gb|EFA04539.1| hypothetical protein TcasGA2_TC010898 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52464 BP_3 44.30 3.66 875 642934467 XP_008197675.1 734 4.4e-75 PREDICTED: alpha-sarcoglycan isoform X1 [Tribolium castaneum]>gi|270013517|gb|EFA09965.1| hypothetical protein TcasGA2_TC012123 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82350 130 2.0e-06 Alpha-sarcoglycan OS=Mus musculus GN=Sgca PE=1 SV=1 PF05510 Sarcoglycan alpha/epsilon -- -- -- -- GO:0016012 sarcoglycan complex -- -- Cluster-8309.52469 BP_3 353.73 6.85 2779 642929061 XP_008195675.1 998 3.4e-105 PREDICTED: metastasis suppressor protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205//PF14980 WH2 motif//TIP39 peptide GO:0007218 neuropeptide signaling pathway GO:0003779 actin binding GO:0005576 extracellular region -- -- Cluster-8309.52470 BP_3 84.38 2.18 2155 642911919 XP_008199022.1 827 1.8e-85 PREDICTED: casein kinase I isoform gamma-3-like isoform X2 [Tribolium castaneum] 884956669 XM_010871844.2 98 3.23331e-41 PREDICTED: Esox lucius casein kinase 1, gamma 2 (csnk1g2), transcript variant X4, mRNA K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q8WQ99 687 1.3e-70 Casein kinase I gamma OS=Caenorhabditis elegans GN=csnk-1 PE=3 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.52473 BP_3 34.68 8.82 481 270003964 EFA00412.1 182 2.5e-11 hypothetical protein TcasGA2_TC003263 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13639//PF00097//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.52474 BP_3 186.60 2.80 3509 642915289 XP_975869.2 2037 1.4e-225 PREDICTED: RING finger and SPRY domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R881 1386 1.8e-151 RING finger and SPRY domain-containing protein 1 OS=Pongo abelii GN=RSPRY1 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.52478 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52481 BP_3 1.00 1.46 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52483 BP_3 26.32 0.68 2147 34099638 AAQ57129.1 1222 2.8e-131 endonuclease and reverse transcriptase-like protein [Bombyx mori] 347439535 JN415099.1 335 5.76011e-173 Scylla paramamosain clone QX04 microsatellite sequence -- -- -- -- Q95SX7 373 3.2e-34 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF09004 Domain of unknown function (DUF1891) GO:0055114 oxidation-reduction process GO:0008168//GO:0016706 methyltransferase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.52485 BP_3 43.51 0.35 6247 642927276 XP_008195203.1 338 2.6e-28 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52490 BP_3 2.00 2.97 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52497 BP_3 18.41 0.38 2615 91076832 XP_974636.1 1062 1.2e-112 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08648 296 3.3e-25 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 -- -- -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.52499 BP_3 54.20 4.23 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.525 BP_3 59.00 1.67 1995 478263113 ENN81506.1 748 2.4e-76 hypothetical protein YQE_02035, partial [Dendroctonus ponderosae]>gi|546675494|gb|ERL86679.1| hypothetical protein D910_04085, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 279 2.4e-23 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF01975//PF00379 Survival protein SurE//Insect cuticle protein -- -- GO:0016787//GO:0042302 hydrolase activity//structural constituent of cuticle -- -- -- -- Cluster-8309.52500 BP_3 151.54 0.84 8989 478256070 ENN76269.1 1241 7.3e-133 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 268 2.0e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF04111//PF03462//PF05823//PF00170//PF06005//PF01576//PF10473//PF01008//PF00866//PF08919//PF00769//PF01025//PF07716//PF06220//PF16331//PF07851//PF04977//PF04508//PF06305//PF05837//PF04559//PF03233 Autophagy protein Apg6//PCRF domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//bZIP transcription factor//Protein of unknown function (DUF904)//Myosin tail//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Initiation factor 2 subunit family//Ring hydroxylating beta subunit//F-actin binding//Ezrin/radixin/moesin family//GrpE//Basic region leucine zipper//U1 zinc finger//TolA binding protein trimerisation//TMPIT-like protein//Septum formation initiator//Viral A-type inclusion protein repeat//Protein of unknown function (DUF1049)//Centromere protein H (CENP-H)//Herpesvirus UL17 protein//Aphid transmission protein GO:0055114//GO:0006415//GO:0044237//GO:0051382//GO:0006725//GO:0019089//GO:0016032//GO:0007049//GO:0006323//GO:0006355//GO:0070206//GO:0006914//GO:0006468//GO:0043093//GO:0000917//GO:0006457//GO:0006449 oxidation-reduction process//translational termination//cellular metabolic process//kinetochore assembly//cellular aromatic compound metabolic process//transmission of virus//viral process//cell cycle//DNA packaging//regulation of transcription, DNA-templated//protein trimerization//autophagy//protein phosphorylation//FtsZ-dependent cytokinesis//barrier septum assembly//protein folding//regulation of translational termination GO:0003700//GO:0051087//GO:0045502//GO:0008134//GO:0005524//GO:0003774//GO:0008092//GO:0008289//GO:0000774//GO:0008270//GO:0043565//GO:0042803//GO:0016149//GO:0004715//GO:0003824 transcription factor activity, sequence-specific DNA binding//chaperone binding//dynein binding//transcription factor binding//ATP binding//motor activity//cytoskeletal protein binding//lipid binding//adenyl-nucleotide exchange factor activity//zinc ion binding//sequence-specific DNA binding//protein homodimerization activity//translation release factor activity, codon specific//non-membrane spanning protein tyrosine kinase activity//catalytic activity GO:0018444//GO:0019898//GO:0000776//GO:0005667//GO:0030286//GO:0005737//GO:0005840//GO:0005887//GO:0016459//GO:0016021//GO:0019012 translation release factor complex//extrinsic component of membrane//kinetochore//transcription factor complex//dynein complex//cytoplasm//ribosome//integral component of plasma membrane//myosin complex//integral component of membrane//virion -- -- Cluster-8309.52502 BP_3 132.00 4.73 1637 642922824 XP_008193341.1 354 9.5e-31 PREDICTED: uncharacterized protein LOC103313006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04706//PF02172 Dickkopf N-terminal cysteine-rich region//KIX domain GO:0006355//GO:0007275//GO:0030178 regulation of transcription, DNA-templated//multicellular organismal development//negative regulation of Wnt signaling pathway GO:0003712 transcription cofactor activity GO:0005576//GO:0005667 extracellular region//transcription factor complex -- -- Cluster-8309.52505 BP_3 210.33 2.06 5204 641658099 XP_008180596.1 1075 7.5e-114 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 967 1.0e-102 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF13465//PF00096//PF16622//PF07776//PF00400//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//WD domain, G-beta repeat//C2H2-type zinc finger -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.52508 BP_3 11.99 0.40 1746 642920075 XP_008192196.1 1108 3.8e-118 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 695 1.2e-71 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03453//PF03454 MoeA N-terminal region (domain I and II)//MoeA C-terminal region (domain IV) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.52509 BP_3 93.00 2.46 2114 642919263 XP_008191800.1 2060 1.8e-228 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGM5 1006 1.3e-107 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.52511 BP_3 97.00 4.34 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52512 BP_3 5.26 0.35 1023 642926582 XP_008194929.1 347 3.8e-30 PREDICTED: lipoma-preferred partner homolog isoform X1 [Tribolium castaneum] 642926583 XM_962896.2 109 1.15818e-47 PREDICTED: Tribolium castaneum lipoma-preferred partner homolog (LOC656358), transcript variant X2, mRNA K16676 LPP lipoma-prefererred partner http://www.genome.jp/dbget-bin/www_bget?ko:K16676 Q5F464 264 6.7e-22 Lipoma-preferred partner homolog OS=Gallus gallus GN=LPP PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.52514 BP_3 6.52 0.35 1185 91083575 XP_968060.1 503 3.6e-48 PREDICTED: ribonuclease H2 subunit B [Tribolium castaneum]>gi|270007823|gb|EFA04271.1| hypothetical protein TcasGA2_TC014561 [Tribolium castaneum] -- -- -- -- -- K10744 RNASEH2B ribonuclease H2 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10744 Q28GD9 195 7.7e-14 Ribonuclease H2 subunit B OS=Xenopus tropicalis GN=rnaseh2b PE=2 SV=1 -- -- -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.52515 BP_3 4.00 0.40 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52517 BP_3 2.00 0.36 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52523 BP_3 68.23 1.02 3524 478259502 ENN79383.1 3958 0.0e+00 hypothetical protein YQE_04170, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- H9JIQ1 3089 0.0e+00 Protein mesh OS=Bombyx mori PE=1 SV=1 PF00779//PF05434//PF04277//PF06119//PF01833//PF02487 BTK motif//TMEM9//Oxaloacetate decarboxylase, gamma chain//Nidogen-like//IPT/TIG domain//CLN3 protein GO:0006525//GO:0006560//GO:0006814//GO:0007160//GO:0006090//GO:0071436//GO:0035556 arginine metabolic process//proline metabolic process//sodium ion transport//cell-matrix adhesion//pyruvate metabolic process//sodium ion export//intracellular signal transduction GO:0008948//GO:0005515//GO:0015081 oxaloacetate decarboxylase activity//protein binding//sodium ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG4291 Mucin/alpha-tectorin Cluster-8309.52525 BP_3 69.83 1.16 3181 642910319 XP_969877.2 1984 1.8e-219 PREDICTED: uridine-cytidine kinase-like 1 [Tribolium castaneum] 602627952 XM_007420856.1 35 5.03851e-06 PREDICTED: Python bivittatus uridine-cytidine kinase-like 1-like (LOC103062425), mRNA K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q91YL3 1136 1.6e-122 Uridine-cytidine kinase-like 1 OS=Mus musculus GN=Uckl1 PE=2 SV=1 PF03205//PF07931//PF01121//PF06414//PF01583//PF00485//PF02224 Molybdopterin guanine dinucleotide synthesis protein B//Chloramphenicol phosphotransferase-like protein//Dephospho-CoA kinase//Zeta toxin//Adenylylsulphate kinase//Phosphoribulokinase / Uridine kinase family//Cytidylate kinase GO:0006144//GO:0000103//GO:0006139//GO:0008152//GO:0015940//GO:0015937//GO:0006777//GO:0006206 purine nucleobase metabolic process//sulfate assimilation//nucleobase-containing compound metabolic process//metabolic process//pantothenate biosynthetic process//coenzyme A biosynthetic process//Mo-molybdopterin cofactor biosynthetic process//pyrimidine nucleobase metabolic process GO:0004020//GO:0005524//GO:0016740//GO:0004140//GO:0005525//GO:0004127//GO:0016301 adenylylsulfate kinase activity//ATP binding//transferase activity//dephospho-CoA kinase activity//GTP binding//cytidylate kinase activity//kinase activity -- -- KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.52527 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5253 BP_3 10.32 0.31 1923 270009196 EFA05644.1 946 2.5e-99 hypothetical protein TcasGA2_TC015853 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62052 560 6.0e-56 P protein OS=Mus musculus GN=Oca2 PE=1 SV=1 PF00957//PF03600//PF00939//PF00089 Synaptobrevin//Citrate transporter//Sodium:sulfate symporter transmembrane region//Trypsin GO:0006810//GO:0016192//GO:0055085//GO:0006508//GO:0006814 transport//vesicle-mediated transport//transmembrane transport//proteolysis//sodium ion transport GO:0005215//GO:0004252 transporter activity//serine-type endopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.52531 BP_3 16.35 0.42 2189 642911136 XP_008200596.1 1379 1.8e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 7.0e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.52532 BP_3 5.61 0.69 681 91084661 XP_967669.1 533 6.9e-52 PREDICTED: protein phosphatase 1D [Tribolium castaneum]>gi|270008629|gb|EFA05077.1| hypothetical protein TcasGA2_TC015174 [Tribolium castaneum] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O80871 158 8.7e-10 Probable protein phosphatase 2C 25 OS=Arabidopsis thaliana GN=At2g30020 PE=1 SV=1 PF00481 Protein phosphatase 2C GO:0006470 protein dephosphorylation GO:0046872//GO:0004722//GO:0003824 metal ion binding//protein serine/threonine phosphatase activity//catalytic activity GO:0008287 protein serine/threonine phosphatase complex KOG0698 Serine/threonine protein phosphatase Cluster-8309.52533 BP_3 851.52 16.04 2850 91086723 XP_970869.1 1296 9.7e-140 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 7.49068e-09 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 697 1.1e-71 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.52534 BP_3 132.15 4.02 1875 332373656 AEE61969.1 1637 1.8e-179 unknown [Dendroctonus ponderosae] 571430507 KF255600.1 387 0 Plutella xylostella protein phosphatase 4 mRNA, complete cds K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 Q5R6K8 1586 6.2e-175 Serine/threonine-protein phosphatase 4 catalytic subunit OS=Pongo abelii GN=PPP4C PE=2 SV=1 PF00149//PF01429 Calcineurin-like phosphoesterase//Methyl-CpG binding domain -- -- GO:0016787//GO:0003677 hydrolase activity//DNA binding GO:0005634 nucleus KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-8309.52540 BP_3 431.91 3.50 6234 270006670 EFA03118.1 1114 2.7e-118 hypothetical protein TcasGA2_TC013028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01349//PF02205 Flavivirus non-structural protein NS4B//WH2 motif GO:0006144//GO:0006396//GO:0009451//GO:0006370 purine nucleobase metabolic process//RNA processing//RNA modification//7-methylguanosine mRNA capping GO:0003779//GO:0004482//GO:0017111//GO:0004483//GO:0004252//GO:0016817//GO:0070008//GO:0003968 actin binding//mRNA (guanine-N7-)-methyltransferase activity//nucleoside-triphosphatase activity//mRNA (nucleoside-2'-O-)-methyltransferase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//serine-type exopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.52541 BP_3 8.94 0.81 823 239789106 BAH71199.1 360 9.6e-32 hypothetical protein [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52544 BP_3 65.27 1.13 3077 642915944 XP_008190822.1 1636 3.9e-179 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X1 [Tribolium castaneum]>gi|270003748|gb|EFA00196.1| hypothetical protein TcasGA2_TC003021 [Tribolium castaneum] -- -- -- -- -- K15047 HNRNPUL1, E1BAP5 heterogeneous nuclear ribonucleoprotein U-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15047 Q9BUJ2 496 2.5e-48 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens GN=HNRNPUL1 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.52550 BP_3 650.34 5.57 5923 642937841 XP_008200323.1 1942 2.5e-214 PREDICTED: thyroid adenoma-associated protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8C756 578 1.5e-57 Thyroid adenoma-associated protein homolog OS=Mus musculus GN=Thada PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1810 Cell cycle-associated protein Cluster-8309.52551 BP_3 43.53 2.67 1079 640788486 XP_008050052.1 230 1.5e-16 PREDICTED: zinc finger protein 208-like, partial [Tarsius syrichta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q02525 210 1.3e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF13465//PF00096//PF07776//PF06221//PF13912//PF01363 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Putative zinc finger motif, C2HC5-type//C2H2-type zinc finger//FYVE zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.52556 BP_3 22.71 0.97 1419 748995286 AJE75665.1 932 7.8e-98 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 684 1.8e-70 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232//PF07243//PF00150 Glycosyl hydrolase family 1//Phlebovirus glycoprotein G1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0019012//GO:0016021 virion//integral component of membrane -- -- Cluster-8309.52557 BP_3 492.82 4.61 5444 642914333 XP_008201635.1 2633 1.7e-294 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum] 752869466 XM_011253546.1 368 0 PREDICTED: Camponotus floridanus glutamate receptor ionotropic, kainate 2 (LOC105248646), transcript variant X2, mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1448 1.8e-158 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF10613//PF00060//PF15163 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//Meiosis-expressed GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.5256 BP_3 1.00 0.31 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52562 BP_3 520.66 7.63 3582 642918209 XP_008191412.1 1177 7.7e-126 PREDICTED: methyltransferase-like protein 9 isoform X1 [Tribolium castaneum]>gi|270004533|gb|EFA00981.1| hypothetical protein TcasGA2_TC003894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EPL4 639 7.7e-65 Methyltransferase-like protein 9 OS=Mus musculus GN=Mettl9 PE=2 SV=1 PF01234//PF04218//PF08241//PF05958 NNMT/PNMT/TEMT family//CENP-B N-terminal DNA-binding domain//Methyltransferase domain//tRNA (Uracil-5-)-methyltransferase GO:0009451//GO:0008152//GO:0006396 RNA modification//metabolic process//RNA processing GO:0003677//GO:0008168//GO:0008173 DNA binding//methyltransferase activity//RNA methyltransferase activity -- -- KOG3987 Uncharacterized conserved protein DREV/CGI-81 Cluster-8309.52566 BP_3 1.00 0.36 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52567 BP_3 380.73 12.31 1782 642919019 XP_008191698.1 1526 1.3e-166 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1L8F9 535 4.4e-53 UPF0536 protein C12orf66 homolog OS=Danio rerio GN=si:ch211-125a15.1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52570 BP_3 51.63 0.84 3261 817212181 XP_012282266.1 793 2.4e-81 PREDICTED: uncharacterized protein LOC105700713 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02563//PF02066 Polysaccharide biosynthesis/export protein//Metallothionein family 11 GO:0015774 polysaccharide transport GO:0015159//GO:0005507 polysaccharide transmembrane transporter activity//copper ion binding GO:0016020 membrane -- -- Cluster-8309.52571 BP_3 67.05 1.12 3180 642933791 XP_008197311.1 3775 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2210 4.6e-247 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF03193//PF17001//PF00005//PF01926//PF13304//PF00664 Protein of unknown function, DUF258//Type III secretion basal body protein I, YscI, HrpB, PscI//ABC transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810//GO:0009306 transmembrane transport//transport//protein secretion GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.52573 BP_3 285.86 2.77 5257 642934658 XP_008197755.1 4283 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.0668e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 531 3.8e-52 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF01702//PF08727 PDZ domain (Also known as DHR or GLGF)//Queuine tRNA-ribosyltransferase//Poliovirus 3A protein like GO:0006400//GO:0006508//GO:0006144//GO:0008616 tRNA modification//proteolysis//purine nucleobase metabolic process//queuosine biosynthetic process GO:0017111//GO:0004197//GO:0003968//GO:0005515//GO:0008479 nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity//protein binding//queuine tRNA-ribosyltransferase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.52574 BP_3 33.65 0.47 3736 478255214 ENN75443.1 217 1.7e-14 hypothetical protein YQE_07994, partial [Dendroctonus ponderosae]>gi|546675119|gb|ERL86366.1| hypothetical protein D910_03774 [Dendroctonus ponderosae] 805772222 XM_012281473.1 39 3.54239e-08 PREDICTED: Megachile rotundata probable protein phosphatase CG10417 (LOC100882395), mRNA K17499 PPM1G, PP2CG protein phosphatase 1G http://www.genome.jp/dbget-bin/www_bget?ko:K17499 Q7K4Q5 175 5.1e-11 Probable protein phosphatase CG10417 OS=Drosophila melanogaster GN=CG10417 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52577 BP_3 504.31 4.44 5768 189241444 XP_972982.2 2726 3.0e-305 PREDICTED: uncharacterized protein LOC661743 isoform X1 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.1493e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.8e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF01166//PF02346 TSC-22/dip/bun family//Chordopoxvirus multifunctional envelope protein A27 GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.52578 BP_3 65.51 0.77 4397 642914860 XP_008195065.1 1758 4.0e-193 PREDICTED: myosin light chain kinase, smooth muscle-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q15746 694 3.9e-71 Myosin light chain kinase, smooth muscle OS=Homo sapiens GN=MYLK PE=1 SV=4 PF08469//PF07714//PF00069 Nucleoside triphosphatase I C-terminal//Protein tyrosine kinase//Protein kinase domain GO:0006351//GO:0006468 transcription, DNA-templated//protein phosphorylation GO:0005524//GO:0004672//GO:0017111 ATP binding//protein kinase activity//nucleoside-triphosphatase activity -- -- -- -- Cluster-8309.52579 BP_3 18.00 1.15 1045 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00906 Hepatitis core antigen GO:0009405 pathogenesis GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.52580 BP_3 952.89 43.73 1342 828177651 AKK25148.1 438 1.4e-40 chemosensory protein 4 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 251 2.8e-20 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.52581 BP_3 450.74 5.44 4285 641649257 XP_008185321.1 466 2.6e-43 PREDICTED: uncharacterized protein LOC103310050 [Acyrthosiphon pisum] -- -- -- -- -- K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8CGZ0 259 1.1e-20 Calcium homeostasis endoplasmic reticulum protein OS=Mus musculus GN=Cherp PE=1 SV=1 PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- KOG4368 Predicted RNA binding protein, contains SWAP, RPR and G-patch domains Cluster-8309.52582 BP_3 370.00 7.91 2545 91079060 XP_975158.1 2827 0.0e+00 PREDICTED: polycomb protein Suz12 [Tribolium castaneum]>gi|270004197|gb|EFA00645.1| hypothetical protein TcasGA2_TC003521 [Tribolium castaneum] -- -- -- -- -- K11463 SUZ12 polycomb protein SUZ12 http://www.genome.jp/dbget-bin/www_bget?ko:K11463 Q80U70 1383 2.9e-151 Polycomb protein Suz12 OS=Mus musculus GN=Suz12 PE=1 SV=2 -- -- -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor) Cluster-8309.52585 BP_3 1770.18 5.89 14787 642914247 XP_008201606.1 18917 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 1497 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10611 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF07645//PF00008//PF00028 Calcium-binding EGF domain//EGF-like domain//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.52586 BP_3 101.49 2.64 2145 91090216 XP_968004.1 1600 4.1e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.3e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008476//GO:0008146 protein-tyrosine sulfotransferase activity//sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.52589 BP_3 20.70 1.85 831 478250388 ENN70883.1 835 8.1e-87 hypothetical protein YQE_12288, partial [Dendroctonus ponderosae]>gi|546672880|gb|ERL84603.1| hypothetical protein D910_02031 [Dendroctonus ponderosae] 766925232 XM_011496200.1 50 5.86083e-15 PREDICTED: Ceratosolen solmsi marchali pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (LOC105359580), transcript variant X2, mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 481 3.7e-47 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.52595 BP_3 300.00 2.39 6350 390362249 XP_001190749.2 1176 1.8e-125 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q505D1 689 2.2e-70 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF01637//PF00023//PF08092//PF05396 Ankyrin repeat//Archaeal ATPase//Ankyrin repeat//Magi peptide toxin family//Phage T7 capsid assembly protein GO:0019069//GO:0006810 viral capsid assembly//transport GO:0005524//GO:0019871//GO:0005515 ATP binding//sodium channel inhibitor activity//protein binding GO:0005576 extracellular region KOG4177 Ankyrin Cluster-8309.52597 BP_3 52.80 3.63 992 390362249 XP_001190749.2 311 5.6e-26 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q4UMH6 270 1.3e-22 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52601 BP_3 56.55 2.02 1644 91086285 XP_967226.1 1427 3.6e-155 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13129 1069 4.8e-115 Luciferin 4-monooxygenase OS=Luciola cruciata PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.52602 BP_3 31.45 0.84 2092 91086285 XP_967226.1 1505 4.1e-164 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13129 1101 1.2e-118 Luciferin 4-monooxygenase OS=Luciola cruciata PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.52604 BP_3 11.32 0.67 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52605 BP_3 470.59 12.14 2160 546677792 ERL88559.1 1850 4.2e-204 hypothetical protein D910_05944 [Dendroctonus ponderosae] -- -- -- -- -- K13174 THOC5 THO complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13174 Q6NY52 904 8.6e-96 THO complex subunit 5 homolog OS=Danio rerio GN=thoc5 PE=2 SV=1 PF05773//PF05225 RWD domain//helix-turn-helix, Psq domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG2216 Conserved coiled/coiled coil protein Cluster-8309.52607 BP_3 16.98 2.18 667 332374634 AEE62458.1 293 4.6e-24 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17607 TIPRL, TIP41 type 2A phosphatase activator TIP41 http://www.genome.jp/dbget-bin/www_bget?ko:K17607 O75663 179 3.1e-12 TIP41-like protein OS=Homo sapiens GN=TIPRL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52609 BP_3 83.21 1.48 3005 642937652 XP_966876.3 611 2.8e-60 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95LI3 435 2.9e-41 Zinc finger Y-chromosomal protein OS=Bos taurus GN=ZFY PE=2 SV=1 PF07776//PF05485//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//THAP domain//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.52610 BP_3 16.00 1.03 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.52613 BP_3 31.60 0.53 3150 189239405 XP_001813943.1 2777 2.5e-311 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] 637379439 XM_008125298.1 41 2.30472e-09 PREDICTED: Anolis carolinensis nuclear export mediator factor NEMF-like (LOC103282578), mRNA -- -- -- -- O60524 1933 6.0e-215 Nuclear export mediator factor NEMF OS=Homo sapiens GN=NEMF PE=1 SV=4 PF05615//PF02050//PF08052 Tho complex subunit 7//Flagellar FliJ protein//PyrBI operon leader peptide GO:0071973//GO:0006935//GO:0006397//GO:0019856 bacterial-type flagellum-dependent cell motility//chemotaxis//mRNA processing//pyrimidine nucleobase biosynthetic process GO:0003774 motor activity GO:0000445//GO:0016020//GO:0009288 THO complex part of transcription export complex//membrane//bacterial-type flagellum KOG2030 Predicted RNA-binding protein Cluster-8309.52614 BP_3 6.00 0.42 978 270008217 EFA04665.1 256 1.3e-19 cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 219 1.1e-16 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.52617 BP_3 675.00 18.08 2091 189233809 XP_971005.2 1228 5.5e-132 PREDICTED: protein trapped in endoderm-1 [Tribolium castaneum]>gi|270015127|gb|EFA11575.1| hypothetical protein TcasGA2_TC004716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NDM2 710 2.6e-73 Protein trapped in endoderm-1 OS=Drosophila melanogaster GN=Tre1 PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.52618 BP_3 4.00 0.43 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52619 BP_3 13.89 1.57 717 546677319 ERL88176.1 306 1.5e-25 hypothetical protein D910_05564 [Dendroctonus ponderosae] -- -- -- -- -- K02449 CDK10 cyclin-dependent kinase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K02449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5262 BP_3 2.00 0.35 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52620 BP_3 563.01 7.49 3913 642928921 XP_008195617.1 5063 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 1119 1.8e-120 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.52622 BP_3 24.77 1.10 1377 642925645 XP_008194653.1 1380 8.5e-150 PREDICTED: potassium voltage-gated channel subfamily H member 6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K04905 KCNH2 potassium voltage-gated channel Eag-related subfamily H member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04905 Q9TSZ3 297 1.3e-25 Potassium voltage-gated channel subfamily H member 2 OS=Canis familiaris GN=KCNH2 PE=2 SV=1 PF02213//PF00989//PF08447 GYF domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-8309.52623 BP_3 245.00 1.87 6599 642916796 XP_008199507.1 3278 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61555 1031 5.0e-110 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.52628 BP_3 44.03 3.33 929 746833442 XP_011063369.1 567 1.1e-55 PREDICTED: uncharacterized protein LOC105151387 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52629 BP_3 215.85 4.47 2617 478263077 ENN81477.1 220 5.2e-15 hypothetical protein YQE_02169, partial [Dendroctonus ponderosae]>gi|546682119|gb|ERL92100.1| hypothetical protein D910_09421 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane -- -- Cluster-8309.5263 BP_3 2.00 0.33 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52631 BP_3 6.00 0.36 1099 91083149 XP_971578.1 771 2.8e-79 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P05049 495 1.2e-48 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.52632 BP_3 109.01 0.69 7882 642916594 XP_008191822.1 3080 0.0e+00 PREDICTED: alpha-catulin isoform X2 [Tribolium castaneum] 642916593 XM_008193600.1 658 0 PREDICTED: Tribolium castaneum alpha-catulin (LOC658111), transcript variant X2, mRNA -- -- -- -- Q9UBT7 1143 6.1e-123 Alpha-catulin OS=Homo sapiens GN=CTNNAL1 PE=1 SV=2 PF01044 Vinculin family GO:0007155 cell adhesion GO:0051015 actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.52635 BP_3 396.25 3.78 5349 642929988 XP_008196055.1 2169 1.1e-240 PREDICTED: patj homolog [Tribolium castaneum] -- -- -- -- -- K13804 INAD inactivation no afterpotential D protein http://www.genome.jp/dbget-bin/www_bget?ko:K13804 Q9NB04 727 7.2e-75 Patj homolog OS=Drosophila melanogaster GN=Patj PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.52638 BP_3 442.87 9.18 2617 642921104 XP_008192691.1 1190 1.7e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.7e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF15678//PF09726//PF05279//PF04882//PF02535 Centriole duplication and mitotic chromosome congression//Transmembrane protein//Aspartyl beta-hydroxylase N-terminal region//Peroxin-3//ZIP Zinc transporter GO:0007031//GO:0055085//GO:0030001//GO:0090307 peroxisome organization//transmembrane transport//metal ion transport//mitotic spindle assembly GO:0046873 metal ion transmembrane transporter activity GO:0016021//GO:0016020//GO:0005779 integral component of membrane//membrane//integral component of peroxisomal membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.5264 BP_3 9.00 0.35 1536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52640 BP_3 112.72 1.01 5682 189241815 XP_971376.2 3322 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1079 1.2e-115 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF13180//PF00397//PF00595 PDZ domain//WW domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.52644 BP_3 697.45 31.71 1352 91088179 XP_972438.1 1205 1.6e-129 PREDICTED: hydroxyacylglutathione hydrolase, mitochondrial [Tribolium castaneum]>gi|270012133|gb|EFA08581.1| hypothetical protein TcasGA2_TC006236 [Tribolium castaneum] -- -- -- -- -- K01069 E3.1.2.6, gloB hydroxyacylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01069 Q6P963 899 2.1e-95 Hydroxyacylglutathione hydrolase, mitochondrial OS=Danio rerio GN=hagh PE=2 SV=2 -- -- GO:0006750//GO:0006090 glutathione biosynthetic process//pyruvate metabolic process GO:0004416//GO:0008270 hydroxyacylglutathione hydrolase activity//zinc ion binding -- -- KOG0813 Glyoxylase Cluster-8309.52645 BP_3 46.55 2.35 1247 91090398 XP_970402.1 723 1.2e-73 PREDICTED: mediator of RNA polymerase II transcription subunit 19 [Tribolium castaneum]>gi|270013384|gb|EFA09832.1| hypothetical protein TcasGA2_TC011979 [Tribolium castaneum] 665785746 XM_008550626.1 157 2.94371e-74 PREDICTED: Microplitis demolitor mediator of RNA polymerase II transcription subunit 19 (LOC103572159), mRNA K15137 MED19 mediator of RNA polymerase II transcription subunit 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15137 Q174D3 648 2.4e-66 Mediator of RNA polymerase II transcription subunit 19 OS=Aedes aegypti GN=MED19 PE=3 SV=1 PF10278 Mediator of RNA pol II transcription subunit 19 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.52648 BP_3 29.79 0.81 2074 642911136 XP_008200596.1 1380 1.3e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 6.6e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.52652 BP_3 61.63 0.72 4402 91085935 XP_970328.1 5241 0.0e+00 PREDICTED: 5-oxoprolinase [Tribolium castaneum] 642927487 XM_965235.3 600 0 PREDICTED: Tribolium castaneum 5-oxoprolinase (LOC658884), mRNA K01469 OPLAH, OXP1, oplAH 5-oxoprolinase (ATP-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01469 P97608 4092 0.0e+00 5-oxoprolinase OS=Rattus norvegicus GN=Oplah PE=1 SV=2 PF02538//PF01968 Hydantoinase B/oxoprolinase//Hydantoinase/oxoprolinase -- -- GO:0003824//GO:0016787 catalytic activity//hydrolase activity -- -- KOG1939 Oxoprolinase Cluster-8309.52654 BP_3 90.00 6.28 982 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52655 BP_3 144.49 1.69 4401 91085935 XP_970328.1 5241 0.0e+00 PREDICTED: 5-oxoprolinase [Tribolium castaneum] 642927487 XM_965235.3 600 0 PREDICTED: Tribolium castaneum 5-oxoprolinase (LOC658884), mRNA K01469 OPLAH, OXP1, oplAH 5-oxoprolinase (ATP-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01469 P97608 4092 0.0e+00 5-oxoprolinase OS=Rattus norvegicus GN=Oplah PE=1 SV=2 PF02538//PF01968 Hydantoinase B/oxoprolinase//Hydantoinase/oxoprolinase -- -- GO:0016787//GO:0003824 hydrolase activity//catalytic activity -- -- KOG1939 Oxoprolinase Cluster-8309.52656 BP_3 33.36 1.45 1401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.52664 BP_3 485.45 17.56 1624 332375126 AEE62704.1 758 1.3e-77 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q63528 327 5.2e-29 Replication protein A 32 kDa subunit OS=Rattus norvegicus GN=Rpa2 PE=2 SV=2 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG3108 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit Cluster-8309.52665 BP_3 53.69 1.42 2118 270012126 EFA08574.1 1425 7.9e-155 hypothetical protein TcasGA2_TC006229 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17060 491 6.6e-48 Major royal jelly protein 3 OS=Apis mellifera GN=MRJP3 PE=1 SV=1 PF02978 Signal peptide binding domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle -- -- Cluster-8309.52668 BP_3 271.27 9.10 1729 91087015 XP_974102.1 890 7.1e-93 PREDICTED: protein phosphatase 1 regulatory subunit 21 [Tribolium castaneum]>gi|270009633|gb|EFA06081.1| hypothetical protein TcasGA2_TC008917 [Tribolium castaneum] -- -- -- -- -- K17562 PPP1R21, CCDC128, KLRAQ1 protein phosphatase 1 regulatory subunit 21 http://www.genome.jp/dbget-bin/www_bget?ko:K17562 Q5U3A8 272 1.3e-22 Protein phosphatase 1 regulatory subunit 21 OS=Danio rerio GN=ppp1r21 PE=2 SV=1 PF12639 DNase/tRNase domain of colicin-like bacteriocin -- -- GO:0004519 endonuclease activity -- -- KOG4421 Uncharacterized conserved protein Cluster-8309.52670 BP_3 174.69 8.37 1298 749784476 XP_011146090.1 572 4.0e-56 PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784479|ref|XP_011146091.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784482|ref|XP_011146092.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784485|ref|XP_011146093.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784488|ref|XP_011146094.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- Q9UJG1 401 1.1e-37 Motile sperm domain-containing protein 1 OS=Homo sapiens GN=MOSPD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52672 BP_3 85.17 3.54 1450 642919913 XP_008192122.1 657 6.2e-66 PREDICTED: transcription factor SOX-13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05881 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) GO:0009214 cyclic nucleotide catabolic process GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity GO:0016020 membrane -- -- Cluster-8309.52674 BP_3 1435.92 28.49 2721 546682401 ERL92343.1 1196 3.7e-128 hypothetical protein D910_09660 [Dendroctonus ponderosae] -- -- -- -- -- K14648 ENDOU, PP11 poly(U)-specific endoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K14648 Q9VZ49 735 4.3e-76 Poly(U)-specific endoribonuclease homolog OS=Drosophila melanogaster GN=CG2145 PE=1 SV=1 PF09412 Endoribonuclease XendoU -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2849 Placental protein 11 Cluster-8309.52676 BP_3 41.49 0.74 2990 642926793 XP_008195018.1 3206 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q810B6 1857 3.7e-206 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF01068//PF00651//PF00023//PF13606 ATP dependent DNA ligase domain//BTB/POZ domain//Ankyrin repeat//Ankyrin repeat GO:0006281//GO:0006260//GO:0006310 DNA repair//DNA replication//DNA recombination GO:0003910//GO:0005515//GO:0005524 DNA ligase (ATP) activity//protein binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.52677 BP_3 16.00 0.38 2301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52678 BP_3 223.00 4.28 2802 478255092 ENN75322.1 478 6.8e-45 hypothetical protein YQE_08099, partial [Dendroctonus ponderosae]>gi|546678671|gb|ERL89239.1| hypothetical protein D910_06613 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52680 BP_3 69.32 0.76 4698 270002048 EEZ98495.1 367 8.5e-32 hypothetical protein TcasGA2_TC000995 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.52683 BP_3 60.62 0.77 4093 91094947 XP_968721.1 1275 3.8e-137 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 866 4.2e-91 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF10018//PF06815 Vitamin-D-receptor interacting Mediator subunit 4//Reverse transcriptase connection domain GO:0006357//GO:0006278 regulation of transcription from RNA polymerase II promoter//RNA-dependent DNA replication GO:0003964//GO:0001104 RNA-directed DNA polymerase activity//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2432 Uncharacterized conserved protein Cluster-8309.52685 BP_3 27.16 0.45 3207 478259428 ENN79318.1 1231 3.8e-132 hypothetical protein YQE_04227, partial [Dendroctonus ponderosae]>gi|546675169|gb|ERL86405.1| hypothetical protein D910_03812 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R1R3 469 3.5e-45 StAR-related lipid transfer protein 7, mitochondrial OS=Mus musculus GN=Stard7 PE=2 SV=2 PF00965//PF09452//PF01852 Tissue inhibitor of metalloproteinase//ESCRT-I subunit Mvb12//START domain GO:0032509 endosome transport via multivesicular body sorting pathway GO:0043130//GO:0008289//GO:0008191 ubiquitin binding//lipid binding//metalloendopeptidase inhibitor activity GO:0000813 ESCRT I complex KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.52687 BP_3 107.56 0.77 6989 91087949 XP_972541.1 1210 2.2e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.1e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF12763//PF13606//PF13499//PF13833//PF10591//PF13405//PF13202//PF01694//PF00023//PF00036 Cytoskeletal-regulatory complex EF hand//Ankyrin repeat//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//Rhomboid family//Ankyrin repeat//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515//GO:0004252 calcium ion binding//protein binding//serine-type endopeptidase activity GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.52688 BP_3 33.97 0.53 3358 270007768 EFA04216.1 1199 2.0e-128 hypothetical protein TcasGA2_TC014465 [Tribolium castaneum] 170029938 XM_001842796.1 262 3.44728e-132 Culex quinquefasciatus importin alpha, mRNA -- -- -- -- O35343 981 1.6e-104 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 PF01602//PF00514//PF11698//PF11538//PF10508//PF01749//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Snurportin1//Proteasome non-ATPase 26S subunit//Importin beta binding domain//HEAT repeat GO:0015031//GO:0043248//GO:0006606//GO:0016192//GO:0006886//GO:0015991 protein transport//proteasome assembly//protein import into nucleus//vesicle-mediated transport//intracellular protein transport//ATP hydrolysis coupled proton transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0005737//GO:0000221//GO:0005634 membrane coat//cytoplasm//vacuolar proton-transporting V-type ATPase, V1 domain//nucleus KOG0166 Karyopherin (importin) alpha Cluster-8309.52691 BP_3 216.90 2.34 4751 546678797 ERL89342.1 3014 0.0e+00 hypothetical protein D910_06713 [Dendroctonus ponderosae] 356871507 FO082054.1 40 1.2551e-08 Pichia sorbitophila strain CBS 7064 chromosome F complete sequence K01950 E6.3.5.1, NADSYN1, QNS1, nadE NAD+ synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01950 Q9VYA0 2602 2.4e-292 Probable glutamine-dependent NAD(+) synthetase OS=Drosophila melanogaster GN=CG9940 PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG2303 Predicted NAD synthase, contains CN hydrolase domain Cluster-8309.52692 BP_3 194.05 2.22 4507 91080973 XP_974893.1 1926 1.4e-212 PREDICTED: probable glutamine-dependent NAD(+) synthetase [Tribolium castaneum]>gi|642919960|ref|XP_008192145.1| PREDICTED: probable glutamine-dependent NAD(+) synthetase [Tribolium castaneum]>gi|270005354|gb|EFA01802.1| hypothetical protein TcasGA2_TC007403 [Tribolium castaneum] 356871507 FO082054.1 40 1.19015e-08 Pichia sorbitophila strain CBS 7064 chromosome F complete sequence K01950 E6.3.5.1, NADSYN1, QNS1, nadE NAD+ synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01950 Q9VYA0 1589 6.7e-175 Probable glutamine-dependent NAD(+) synthetase OS=Drosophila melanogaster GN=CG9940 PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807//GO:0046497//GO:0009435 nitrogen compound metabolic process//nicotinate nucleotide metabolic process//NAD biosynthetic process GO:0016810//GO:0005524//GO:0003952 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//ATP binding//NAD+ synthase (glutamine-hydrolyzing) activity -- -- KOG2303 Predicted NAD synthase, contains CN hydrolase domain Cluster-8309.52696 BP_3 17.02 0.44 2159 642927980 XP_008195470.1 774 2.5e-79 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08685 GON domain -- -- GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.52697 BP_3 36.81 0.52 3675 91092536 XP_967769.1 2382 1.5e-265 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 515 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1611 1.5e-177 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF07714//PF06293//PF00069//PF05861 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Bacterial phosphonate metabolism protein (PhnI) GO:0019634//GO:0016310//GO:0009069//GO:0006468 organic phosphonate metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004674//GO:0004672//GO:0016773//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.52698 BP_3 288.91 4.23 3581 642917305 XP_008199244.1 5318 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X5 [Tribolium castaneum] 642917304 XM_008201022.1 925 0 PREDICTED: Tribolium castaneum disco-interacting protein 2 (LOC657292), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3637 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF00501//PF17096//PF06464 AMP-binding enzyme//Altered inheritance of mitochondria protein 3//DMAP1-binding Domain GO:0008152//GO:0051016 metabolic process//barbed-end actin filament capping GO:0003824//GO:0008134 catalytic activity//transcription factor binding GO:0005634//GO:0030479//GO:0005667 nucleus//actin cortical patch//transcription factor complex KOG3628 Predicted AMP-binding protein Cluster-8309.52699 BP_3 72.00 5.41 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03444 Winged helix-turn-helix transcription repressor, HrcA DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.52701 BP_3 217.00 7.72 1647 665794862 XP_008545150.1 679 2.0e-68 PREDICTED: nuclear transcription factor Y subunit gamma-like isoform X2 [Microplitis demolitor] -- -- -- -- -- K08066 NFYC nuclear transcription factor Y, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08066 Q5RA23 501 3.5e-49 Nuclear transcription factor Y subunit gamma OS=Pongo abelii GN=NFYC PE=2 SV=1 PF02969//PF09415//PF00125 TATA box binding protein associated factor (TAF)//CENP-S associating Centromere protein X//Core histone H2A/H2B/H3/H4 GO:0051382//GO:0006352//GO:0006281 kinetochore assembly//DNA-templated transcription, initiation//DNA repair GO:0003677 DNA binding GO:0005634 nucleus KOG1657 CCAAT-binding factor, subunit C (HAP5) Cluster-8309.52702 BP_3 191.86 2.82 3570 642937652 XP_966876.3 248 4.1e-18 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 170 1.8e-10 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF07776//PF00096//PF13465//PF02150 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0008270//GO:0003899//GO:0003677 metal ion binding//zinc ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.52703 BP_3 39.14 1.77 1360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52704 BP_3 56.55 1.15 2656 642937442 XP_008198836.1 676 7.1e-68 PREDICTED: uncharacterized protein LOC103314470 [Tribolium castaneum] -- -- -- -- -- K02088 CDK3 cyclin-dependent kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02088 P43450 262 3.0e-21 Cyclin-dependent kinase 2 OS=Carassius auratus GN=cdk2 PE=2 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.52705 BP_3 351.31 5.95 3138 478256147 ENN76345.1 1286 1.5e-138 hypothetical protein YQE_07122, partial [Dendroctonus ponderosae]>gi|546685758|gb|ERL95213.1| hypothetical protein D910_12480 [Dendroctonus ponderosae] -- -- -- -- -- K02088 CDK3 cyclin-dependent kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02088 P43450 909 3.3e-96 Cyclin-dependent kinase 2 OS=Carassius auratus GN=cdk2 PE=2 SV=1 PF06293//PF00069//PF02098//PF07714//PF04062 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Tick histamine binding protein//Protein tyrosine kinase//ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0006468//GO:0030682//GO:0034314 regulation of actin filament polymerization//protein phosphorylation//evasion or tolerance of host defense response//Arp2/3 complex-mediated actin nucleation GO:0005524//GO:0043176//GO:0016773//GO:0004672 ATP binding//amine binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0005856//GO:0005885//GO:0016020 cytoskeleton//Arp2/3 protein complex//membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.52709 BP_3 51.25 0.32 8095 546680337 ERL90623.1 1560 6.7e-170 hypothetical protein D910_07970 [Dendroctonus ponderosae] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q99489 534 2.6e-52 D-aspartate oxidase OS=Homo sapiens GN=DDO PE=2 SV=1 PF06156//PF01763//PF02985//PF01266 Protein of unknown function (DUF972)//Herpesvirus UL6 like//HEAT repeat//FAD dependent oxidoreductase GO:0006260//GO:0055114//GO:0006323 DNA replication//oxidation-reduction process//DNA packaging GO:0005515//GO:0016491 protein binding//oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.52714 BP_3 6.78 0.40 1107 91085889 XP_967833.1 522 2.1e-50 PREDICTED: UPF0183 protein CG7083 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSH9 403 5.5e-38 UPF0183 protein CG7083 OS=Drosophila melanogaster GN=CG7083 PE=2 SV=1 PF00280 Potato inhibitor I family GO:0009611 response to wounding GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG2819 Uncharacterized conserved protein Cluster-8309.52716 BP_3 117.36 4.93 1438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52717 BP_3 221.36 4.31 2767 91095029 XP_966439.1 854 1.7e-88 PREDICTED: ubiquitin-conjugating enzyme E2 H [Tribolium castaneum]>gi|270014763|gb|EFA11211.1| hypothetical protein TcasGA2_TC005175 [Tribolium castaneum] 462332992 APGK01039128.1 55 3.33476e-17 Dendroctonus ponderosae Seq01039138, whole genome shotgun sequence K10576 UBE2H, UBC8 ubiquitin-conjugating enzyme E2 H http://www.genome.jp/dbget-bin/www_bget?ko:K10576 P62257 751 6.1e-78 Ubiquitin-conjugating enzyme E2 H OS=Mus musculus GN=Ube2h PE=1 SV=1 PF05773 RWD domain -- -- GO:0005524//GO:0016881//GO:0005515 ATP binding//acid-amino acid ligase activity//protein binding -- -- KOG0416 Ubiquitin-protein ligase Cluster-8309.52720 BP_3 16.34 0.36 2496 642929103 XP_008195691.1 417 7.2e-38 PREDICTED: uncharacterized protein LOC655454 [Tribolium castaneum]>gi|270010386|gb|EFA06834.1| hypothetical protein TcasGA2_TC009777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52721 BP_3 56.05 0.41 6951 270005904 EFA02352.1 2947 0.0e+00 hypothetical protein TcasGA2_TC008022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 754 6.9e-78 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3321 Mitochondrial ribosomal protein S10 Cluster-8309.52722 BP_3 16.94 0.41 2297 642924819 XP_008194054.1 910 4.5e-95 PREDICTED: pre-mRNA 3'-end-processing factor FIP1 isoform X1 [Tribolium castaneum] 755881436 XM_005185743.2 56 7.68201e-18 PREDICTED: Musca domestica pre-mRNA 3'-end-processing factor FIP1 (LOC101888314), mRNA K14405 FIP1L1, FIP1 pre-mRNA 3'-end-processing factor FIP1 http://www.genome.jp/dbget-bin/www_bget?ko:K14405 Q9D824 273 1.4e-22 Pre-mRNA 3'-end-processing factor FIP1 OS=Mus musculus GN=Fip1l1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1049 Polyadenylation factor I complex, subunit FIP1 Cluster-8309.52723 BP_3 16.74 0.33 2703 642924819 XP_008194054.1 547 6.5e-53 PREDICTED: pre-mRNA 3'-end-processing factor FIP1 isoform X1 [Tribolium castaneum] 755881436 XM_005185743.2 55 3.25661e-17 PREDICTED: Musca domestica pre-mRNA 3'-end-processing factor FIP1 (LOC101888314), mRNA K14405 FIP1L1, FIP1 pre-mRNA 3'-end-processing factor FIP1 http://www.genome.jp/dbget-bin/www_bget?ko:K14405 Q6UN15 280 2.5e-23 Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens GN=FIP1L1 PE=1 SV=1 PF04279 Intracellular septation protein A -- -- -- -- GO:0016021 integral component of membrane KOG1049 Polyadenylation factor I complex, subunit FIP1 Cluster-8309.52729 BP_3 1018.72 18.33 2970 189237843 XP_974681.2 2191 1.7e-243 PREDICTED: advillin isoform X1 [Tribolium castaneum]>gi|270006740|gb|EFA03188.1| hypothetical protein TcasGA2_TC013108 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q23989 901 2.6e-95 Villin-like protein quail OS=Drosophila melanogaster GN=qua PE=2 SV=2 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG0443 Actin regulatory proteins (gelsolin/villin family) Cluster-8309.52730 BP_3 407.63 1.13 17748 642935122 XP_008197897.1 21876 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 1002 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q61555 1378 7.7e-150 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF06553//PF00008//PF07645 BNIP3//EGF-like domain//Calcium-binding EGF domain GO:0043065 positive regulation of apoptotic process GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.52732 BP_3 3064.00 72.10 2340 642914629 XP_008190291.1 622 1.1e-61 PREDICTED: uncharacterized protein LOC103312160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52733 BP_3 470.43 14.94 1809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52737 BP_3 7.00 0.35 1249 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52739 BP_3 3.00 0.44 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52741 BP_3 14.23 0.52 1608 270016720 EFA13166.1 202 3.9e-13 hypothetical protein TcasGA2_TC002235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 159 1.6e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF05485 Zinc-finger double domain//Zinc finger, C2H2 type//THAP domain -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- -- -- Cluster-8309.52748 BP_3 12.00 1.66 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52751 BP_3 64.55 1.96 1881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52753 BP_3 531.72 5.36 5077 642913582 XP_008201072.1 4497 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 21 [Tribolium castaneum] -- -- -- -- -- K18025 PTPN14_21 tyrosine-protein phosphatase non-receptor type 14/21 http://www.genome.jp/dbget-bin/www_bget?ko:K18025 Q15678 648 9.8e-66 Tyrosine-protein phosphatase non-receptor type 14 OS=Homo sapiens GN=PTPN14 PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.52758 BP_3 8.81 0.62 974 270007903 EFA04351.1 449 5.4e-42 hypothetical protein TcasGA2_TC014647 [Tribolium castaneum] -- -- -- -- -- K09540 SEC63, DNAJC23 translocation protein SEC63 http://www.genome.jp/dbget-bin/www_bget?ko:K09540 Q8VHE0 152 6.2e-09 Translocation protein SEC63 homolog OS=Mus musculus GN=Sec63 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG0721 Molecular chaperone (DnaJ superfamily) Cluster-8309.52761 BP_3 845.83 5.47 7747 170286893 BAG13448.1 5824 0.0e+00 chitinase [Monochamus alternatus] 170286892 AB428669.1 3470 0 Monochamus alternatus MaChiPm1 mRNA for chitinase, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W5U2 1858 7.4e-206 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607//PF00704//PF03970 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18//Herpesvirus UL37 tegument protein GO:0006030//GO:0005975//GO:0019068 chitin metabolic process//carbohydrate metabolic process//virion assembly GO:0004553//GO:0008061 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.52764 BP_3 107.53 1.02 5371 478252068 ENN72499.1 334 6.5e-28 hypothetical protein YQE_10840, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5UPA0 134 4.2e-06 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52768 BP_3 661.00 19.38 1936 642924077 XP_008193997.1 962 3.5e-101 PREDICTED: rho-associated protein kinase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04632 Fusaric acid resistance protein family GO:0006810 transport -- -- GO:0005886 plasma membrane -- -- Cluster-8309.52769 BP_3 838.00 15.44 2907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0047134 protein-disulfide reductase activity -- -- -- -- Cluster-8309.52770 BP_3 36.18 0.51 3690 478250074 ENN70580.1 978 9.4e-103 hypothetical protein YQE_12755, partial [Dendroctonus ponderosae]>gi|546672658|gb|ERL84454.1| hypothetical protein D910_01886 [Dendroctonus ponderosae] 642933290 XM_008199137.1 98 5.57113e-41 PREDICTED: Tribolium castaneum cytochrome b5 reductase 4 (LOC656620), transcript variant X2, mRNA K00326 E1.6.2.2 cytochrome-b5 reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00326 Q68EJ0 395 1.6e-36 Cytochrome b5 reductase 4 OS=Rattus norvegicus GN=Cyb5r4 PE=1 SV=2 PF00175//PF08030 Oxidoreductase NAD-binding domain//Ferric reductase NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0536 Flavohemoprotein b5+b5R Cluster-8309.52773 BP_3 65.59 0.33 9963 189236510 XP_975373.2 2107 3.1e-233 PREDICTED: insulin-like receptor [Tribolium castaneum] 471364329 XM_004372657.1 83 3.29812e-32 PREDICTED: Trichechus manatus latirostris insulin-like growth factor 1 receptor (LOC101355333), mRNA K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q60751 1531 7.9e-168 Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 PF07714//PF01108//PF00069//PF00909//PF00041//PF08727//PF16656 Protein tyrosine kinase//Tissue factor//Protein kinase domain//Ammonium Transporter Family//Fibronectin type III domain//Poliovirus 3A protein like//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006468//GO:0006144//GO:0015696//GO:0006771//GO:0006508 hexachlorocyclohexane metabolic process//protein phosphorylation//purine nucleobase metabolic process//ammonium transport//riboflavin metabolic process//proteolysis GO:0008519//GO:0005524//GO:0003993//GO:0005515//GO:0046872//GO:0004672//GO:0017111//GO:0004197//GO:0003968 ammonium transmembrane transporter activity//ATP binding//acid phosphatase activity//protein binding//metal ion binding//protein kinase activity//nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0031379//GO:0016020 RNA-directed RNA polymerase complex//membrane KOG3796 Ammonium transporter RHBG Cluster-8309.52779 BP_3 63.53 0.87 3829 642932698 XP_008196949.1 1305 1.2e-140 PREDICTED: uncharacterized protein LOC660251 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371//PF06330//PF06367//PF17085//PF10473 Diaphanous GTPase-binding Domain//Trichodiene synthase (TRI5)//Diaphanous FH3 Domain//Unique cartilage matrix associated protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0016043//GO:0016114//GO:0016106//GO:0045667//GO:0030036 cellular component organization//terpenoid biosynthetic process//sesquiterpenoid biosynthetic process//regulation of osteoblast differentiation//actin cytoskeleton organization GO:0008134//GO:0045502//GO:0003779//GO:0045482//GO:0017048//GO:0042803 transcription factor binding//dynein binding//actin binding//trichodiene synthase activity//Rho GTPase binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.52780 BP_3 33.89 0.92 2065 91089769 XP_967094.1 1002 8.7e-106 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 B4MYA4 520 2.8e-51 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.52783 BP_3 97.15 2.54 2138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52786 BP_3 131.67 15.32 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.52792 BP_3 20.27 0.31 3423 270008073 EFA04521.1 768 2.0e-78 hypothetical protein TcasGA2_TC016316 [Tribolium castaneum] -- -- -- -- -- K09200 SP-N transcription factor Sp, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09200 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52793 BP_3 38.85 1.80 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52795 BP_3 44.89 0.53 4413 642931800 XP_008196735.1 1800 5.4e-198 PREDICTED: probable tRNA (guanine(26)-N(2))-dimethyltransferase [Tribolium castaneum] 805826840 XM_012297893.1 36 1.94967e-06 PREDICTED: Megachile rotundata probable tRNA (guanine(26)-N(2))-dimethyltransferase (LOC105664233), mRNA K00555 TRMT1, trm1 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00555 Q9VK89 1491 1.5e-163 Probable tRNA (guanine(26)-N(2))-dimethyltransferase OS=Drosophila melanogaster GN=CG6388 PE=2 SV=1 PF05175//PF03602//PF05958//PF02005 Methyltransferase small domain//Conserved hypothetical protein 95//tRNA (Uracil-5-)-methyltransferase//N2,N2-dimethylguanosine tRNA methyltransferase GO:0008033//GO:0006396//GO:0009451//GO:0031167 tRNA processing//RNA processing//RNA modification//rRNA methylation GO:0008168//GO:0004809//GO:0008173//GO:0003723 methyltransferase activity//tRNA (guanine-N2-)-methyltransferase activity//RNA methyltransferase activity//RNA binding -- -- KOG1253 tRNA methyltransferase Cluster-8309.52796 BP_3 28.04 1.29 1342 91090910 XP_973922.1 973 1.3e-102 PREDICTED: protein rogdi isoform X1 [Tribolium castaneum]>gi|270013221|gb|EFA09669.1| hypothetical protein TcasGA2_TC011795 [Tribolium castaneum] 805780431 XM_012283623.1 73 1.57402e-27 PREDICTED: Megachile rotundata protein rogdi (LOC100879337), transcript variant X2, mRNA -- -- -- -- Q9VVE2 728 1.4e-75 Protein rogdi OS=Drosophila melanogaster GN=rogdi PE=1 SV=2 PF11047 Salmonella outer protein D GO:0009405 pathogenesis -- -- GO:0033644 host cell membrane KOG3992 Uncharacterized conserved protein Cluster-8309.52797 BP_3 16.21 0.45 2025 270008035 EFA04483.1 1789 4.7e-197 hypothetical protein TcasGA2_TC014788 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q9ES28 912 9.6e-97 Rho guanine nucleotide exchange factor 7 OS=Mus musculus GN=Arhgef7 PE=1 SV=2 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG2070 Guanine nucleotide exchange factor Cluster-8309.528 BP_3 4.00 0.91 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52804 BP_3 59.16 2.50 1434 91077544 XP_971725.1 1456 1.4e-158 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X1 [Tribolium castaneum] 642914119 XM_008203330.1 396 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q12923 206 5.0e-15 Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52805 BP_3 14.13 0.40 2012 270010959 EFA07407.1 779 6.1e-80 protein C kinase 98E-like protein [Tribolium castaneum] -- -- -- -- -- K18050 PRKCE novel protein kinase C epsilon type http://www.genome.jp/dbget-bin/www_bget?ko:K18050 Q16975 461 1.9e-44 Calcium-independent protein kinase C OS=Aplysia californica GN=PRKC2 PE=1 SV=1 PF00168//PF00130 C2 domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.52807 BP_3 45.14 0.62 3775 642911809 XP_008200752.1 3666 0.0e+00 PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911811|ref|XP_008200753.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911813|ref|XP_008200754.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 1444 3.7e-158 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52808 BP_3 2.00 2.41 321 478259841 ENN79663.1 220 6.4e-16 hypothetical protein YQE_03897, partial [Dendroctonus ponderosae] -- -- -- -- -- K02727 PSMA3 20S proteasome subunit alpha 7 http://www.genome.jp/dbget-bin/www_bget?ko:K02727 Q58DU5 175 4.4e-12 Proteasome subunit alpha type-3 OS=Bos taurus GN=PSMA3 PE=1 SV=3 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0184 20S proteasome, regulatory subunit alpha type PSMA3/PRE10 Cluster-8309.5281 BP_3 9.36 0.60 1049 189234473 XP_001808764.1 335 9.7e-29 PREDICTED: double-strand-break repair protein rad21 homolog isoform X1 [Tribolium castaneum]>gi|270002814|gb|EEZ99261.1| rad21 [Tribolium castaneum] -- -- -- -- -- K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52810 BP_3 5.00 2.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52811 BP_3 1264.32 28.80 2408 91088039 XP_974446.1 1345 1.7e-145 PREDICTED: erlin-1 [Tribolium castaneum]>gi|270012079|gb|EFA08527.1| hypothetical protein TcasGA2_TC006180 [Tribolium castaneum] 827559147 XM_012695171.1 184 5.64251e-89 PREDICTED: Bombyx mori erlin-2-like (LOC101740340), transcript variant X3, mRNA -- -- -- -- Q28J34 987 2.3e-105 Erlin-2 OS=Xenopus tropicalis GN=erlin2 PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2962 Prohibitin-related membrane protease subunits Cluster-8309.52812 BP_3 44.90 0.78 3067 91088039 XP_974446.1 1345 2.2e-145 PREDICTED: erlin-1 [Tribolium castaneum]>gi|270012079|gb|EFA08527.1| hypothetical protein TcasGA2_TC006180 [Tribolium castaneum] 827559147 XM_012695171.1 184 7.20484e-89 PREDICTED: Bombyx mori erlin-2-like (LOC101740340), transcript variant X3, mRNA -- -- -- -- Q28J34 987 2.9e-105 Erlin-2 OS=Xenopus tropicalis GN=erlin2 PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2962 Prohibitin-related membrane protease subunits Cluster-8309.52813 BP_3 281.00 3.28 4422 270001525 EEZ97972.1 1337 2.7e-144 hypothetical protein TcasGA2_TC000367 [Tribolium castaneum] 642914332 XM_008203413.1 376 0 PREDICTED: Tribolium castaneum glutamate receptor ionotropic, kainate 2 (LOC663783), mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P39087 583 3.0e-58 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.52817 BP_3 6.18 1.14 552 646708837 KDR14984.1 203 1.0e-13 Sodium-coupled monocarboxylate transporter 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8BYF6 135 3.3e-07 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus GN=Slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.52821 BP_3 233.50 2.82 4283 642937652 XP_966876.3 827 3.5e-85 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6B4Z5 368 2.4e-33 Zinc finger Y-chromosomal protein OS=Pan troglodytes GN=ZFY PE=2 SV=1 PF02738//PF13465//PF00096 Molybdopterin-binding domain of aldehyde dehydrogenase//Zinc-finger double domain//Zinc finger, C2H2 type GO:0055114 oxidation-reduction process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.52823 BP_3 125.08 4.07 1773 167234449 NP_001107839.1 919 3.1e-96 eagle [Tribolium castaneum]>gi|270004095|gb|EFA00543.1| hypothetical protein TcasGA2_TC003409 [Tribolium castaneum] 41223450 AJ621748.1 205 8.75767e-101 Tribolium castaneum partial mRNA for zinc finger transcription factor (eagle gene) K08706 NR0AN, kni nuclear receptor subfamily 0 group A http://www.genome.jp/dbget-bin/www_bget?ko:K08706 P13054 490 7.2e-48 Knirps-related protein OS=Drosophila melanogaster GN=knrl PE=2 SV=1 PF00105 Zinc finger, C4 type (two domains) GO:0006355//GO:0009987 regulation of transcription, DNA-templated//cellular process GO:0043565//GO:0005488//GO:0008270//GO:0003700 sequence-specific DNA binding//binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.52824 BP_3 13.00 1.13 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52828 BP_3 114.03 1.54 3860 642915691 XP_008190761.1 3109 0.0e+00 PREDICTED: cyclic nucleotide-gated cation channel subunit A [Tribolium castaneum] 170060746 XM_001865903.1 397 0 Culex quinquefasciatus cyclic-nucleotide-gated cation channel, mRNA K04950 CNGA3 cyclic nucleotide gated channel alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04950 Q24278 2169 3.2e-242 Cyclic nucleotide-gated cation channel subunit A OS=Drosophila melanogaster GN=CngA PE=2 SV=2 PF05929//PF00520//PF02173 Phage capsid scaffolding protein (GPO) serine peptidase//Ion transport protein//pKID domain GO:0006355//GO:0055085//GO:0019069//GO:0006811 regulation of transcription, DNA-templated//transmembrane transport//viral capsid assembly//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.52830 BP_3 667.41 5.49 6156 742090774 XP_010831732.1 714 6.4e-72 PREDICTED: zinc finger protein 665-like, partial [Bison bison bison] 297723644 NM_001187257.1 43 3.50153e-10 Oryza sativa Japonica Group Os05g0117798 (Os05g0117798) mRNA, complete cds K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q14590 669 4.4e-68 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF07975//PF13465//PF00225//PF16622//PF13912//PF00096//PF07776//PF06467//PF05531 TFIIH C1-like domain//Zinc-finger double domain//Kinesin motor domain//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//Nucleopolyhedrovirus P10 protein GO:0007017//GO:0006281//GO:0007018 microtubule-based process//DNA repair//microtubule-based movement GO:0046872//GO:0008017//GO:0008270//GO:0003777//GO:0005524 metal ion binding//microtubule binding//zinc ion binding//microtubule motor activity//ATP binding GO:0045298//GO:0005874//GO:0019028//GO:0005634 tubulin complex//microtubule//viral capsid//nucleus -- -- Cluster-8309.52831 BP_3 51.38 0.32 8008 21755011 BAC04610.1 526 5.3e-50 unnamed protein product [Homo sapiens] 297723644 NM_001187257.1 43 4.55914e-10 Oryza sativa Japonica Group Os05g0117798 (Os05g0117798) mRNA, complete cds K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 A0JNB1 521 8.3e-51 Zinc finger protein 227 OS=Bos taurus GN=ZNF227 PE=2 SV=1 PF01155//PF00096//PF06467//PF05715//PF05531//PF07649//PF07975//PF13465//PF16622//PF00225//PF01428//PF13912//PF02892//PF04810//PF00412 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//Piccolo Zn-finger//Nucleopolyhedrovirus P10 protein//C1-like domain//TFIIH C1-like domain//Zinc-finger double domain//zinc-finger C2H2-type//Kinesin motor domain//AN1-like Zinc finger//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger//LIM domain GO:0007018//GO:0006464//GO:0006886//GO:0006281//GO:0007017//GO:0055114//GO:0006888 microtubule-based movement//cellular protein modification process//intracellular protein transport//DNA repair//microtubule-based process//oxidation-reduction process//ER to Golgi vesicle-mediated transport GO:0005524//GO:0008270//GO:0047134//GO:0003677//GO:0016151//GO:0003777//GO:0008017//GO:0046872 ATP binding//zinc ion binding//protein-disulfide reductase activity//DNA binding//nickel cation binding//microtubule motor activity//microtubule binding//metal ion binding GO:0030127//GO:0019028//GO:0045298//GO:0045202//GO:0005874 COPII vesicle coat//viral capsid//tubulin complex//synapse//microtubule -- -- Cluster-8309.52833 BP_3 33.13 0.42 4134 642932900 XP_008197178.1 1785 2.8e-196 PREDICTED: carboxypeptidase M isoform X1 [Tribolium castaneum] 170072561 XM_001870172.1 155 1.28713e-72 Culex quinquefasciatus carboxypeptidase D, mRNA K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 983 1.1e-104 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016788//GO:0008270//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//metallocarboxypeptidase activity -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.52834 BP_3 18.56 0.93 1257 642932902 XP_008197179.1 985 4.9e-104 PREDICTED: carboxypeptidase M isoform X2 [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 P14384 449 2.9e-43 Carboxypeptidase M OS=Homo sapiens GN=CPM PE=1 SV=2 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0004181//GO:0008270 metallocarboxypeptidase activity//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.52835 BP_3 67.13 3.07 1347 642912083 XP_008200795.1 598 4.0e-59 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- F1MLX5 162 5.9e-10 Leucine-rich repeat-containing G-protein coupled receptor 4 OS=Bos taurus GN=LGR4 PE=3 SV=3 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52838 BP_3 28.31 2.12 936 189236619 XP_001816527.1 588 4.0e-58 PREDICTED: N-alpha-acetyltransferase 20 [Tribolium castaneum]>gi|270005230|gb|EFA01678.1| hypothetical protein TcasGA2_TC007251 [Tribolium castaneum] 572306440 XM_006619049.1 99 3.82611e-42 PREDICTED: Apis dorsata N-alpha-acetyltransferase 20-like (LOC102677987), transcript variant X1, mRNA K17972 NAA20, NAT3 N-terminal acetyltransferase B complex catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17972 Q58ED9 453 7.4e-44 N-alpha-acetyltransferase 20 OS=Danio rerio GN=naa20 PE=2 SV=1 PF00583//PF13508//PF13673//PF08445 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3234 Acetyltransferase, (GNAT) family Cluster-8309.52842 BP_3 7.83 0.69 838 642921219 XP_968442.2 299 1.2e-24 PREDICTED: uncharacterized protein LOC656848 isoform X2 [Tribolium castaneum]>gi|270005083|gb|EFA01531.1| hypothetical protein TcasGA2_TC007091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5Y4U4 129 2.5e-06 U8-agatoxin-Ao1a OS=Agelena orientalis PE=2 SV=1 PF05039//PF02950//PF02819 Agouti protein//Conotoxin//Spider toxin GO:0006810//GO:0009755//GO:0009405 transport//hormone-mediated signaling pathway//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.52843 BP_3 17.00 0.42 2255 646720121 KDR21968.1 1734 1.3e-190 Protein henna [Zootermopsis nevadensis] 158294631 XM_315721.4 287 2.91839e-146 Anopheles gambiae str. PEST AGAP005712-PC (AgaP_AGAP005712) mRNA, complete cds K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 1634 2.0e-180 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF01842//PF00351 ACT domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016714//GO:0016597 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//amino acid binding -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.52845 BP_3 249.30 7.01 2006 189241120 XP_973128.2 1177 4.3e-126 PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935513|ref|XP_008198040.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935515|ref|XP_008198041.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K17617 CTDNEP1, DULLARD, NEM1 CTD nuclear envelope phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17617 Q9VRG7 961 2.0e-102 CTD nuclear envelope phosphatase 1 homolog OS=Drosophila melanogaster GN=Dd PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.52846 BP_3 73.41 1.68 2403 91087247 XP_975518.1 1185 6.1e-127 PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929756|ref|XP_008195961.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929758|ref|XP_008195962.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929760|ref|XP_008195963.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCX5 279 2.9e-23 Proton-coupled folate transporter OS=Xenopus laevis GN=slc46a1 PE=2 SV=1 PF07690//PF03137 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.52847 BP_3 79.50 0.86 4741 642926255 XP_008194846.1 2554 2.2e-285 PREDICTED: kelch-like protein 17 [Tribolium castaneum]>gi|270008515|gb|EFA04963.1| hypothetical protein TcasGA2_TC015037 [Tribolium castaneum] 195029940 XM_001987794.1 64 5.70467e-22 Drosophila grimshawi GH19736 (Dgri\GH19736), mRNA K10454 KLHL17 kelch-like protein 17 (actinfilin) http://www.genome.jp/dbget-bin/www_bget?ko:K10454 Q6TDP3 1675 7.5e-185 Kelch-like protein 17 OS=Mus musculus GN=Klhl17 PE=2 SV=1 PF01344//PF00651//PF07646//PF00884//PF01663 Kelch motif//BTB/POZ domain//Kelch motif//Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0005515//GO:0003824//GO:0008484 protein binding//catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.52848 BP_3 85.88 1.22 3671 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 7.1e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00072//PF00989//PF09771//PF00233//PF05504 Response regulator receiver domain//PAS fold//Transmembrane protein 188//3'5'-cyclic nucleotide phosphodiesterase//Spore germination B3/ GerAC like, C-terminal GO:0009847//GO:0006355//GO:0006144//GO:0007165//GO:0035307//GO:0000160 spore germination//regulation of transcription, DNA-templated//purine nucleobase metabolic process//signal transduction//positive regulation of protein dephosphorylation//phosphorelay signal transduction system GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.52849 BP_3 247.35 1.55 7988 242008211 XP_002424904.1 2464 1.0e-274 zinc finger protein, putative [Pediculus humanus corporis]>gi|212508484|gb|EEB12166.1| zinc finger protein, putative [Pediculus humanus corporis] 817192597 XM_012416318.1 430 0 PREDICTED: Orussus abietinus zinc finger protein 665-like (LOC105695064), transcript variant X6, mRNA -- -- -- -- P51523 1365 1.1e-148 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF13912//PF14764//PF06467 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//AP-5 complex subunit, vesicle trafficking//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0005488//GO:0008270 metal ion binding//binding//zinc ion binding GO:0044599 AP-5 adaptor complex -- -- Cluster-8309.52850 BP_3 60.89 1.17 2801 478254777 ENN75013.1 924 1.3e-96 hypothetical protein YQE_08329, partial [Dendroctonus ponderosae] -- -- -- -- -- K11536 SLC28A pyrimidine nucleoside transport protein http://www.genome.jp/dbget-bin/www_bget?ko:K11536 Q62773 538 3.1e-53 Sodium/nucleoside cotransporter 2 OS=Rattus norvegicus GN=Slc28a2 PE=1 SV=1 PF03577 Peptidase family C69 GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- KOG3747 Concentrative Na+-nucleoside cotransporter CNT1/CNT2 Cluster-8309.52852 BP_3 31.25 1.09 1674 780704567 XP_011702891.1 953 3.4e-100 PREDICTED: probable G-protein coupled receptor No9 isoform X2 [Wasmannia auropunctata] -- -- -- -- -- K04135 ADRA1A adrenergic receptor alpha-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04135 P35348 514 1.1e-50 Alpha-1A adrenergic receptor OS=Homo sapiens GN=ADRA1A PE=1 SV=2 PF00001//PF01498 7 transmembrane receptor (rhodopsin family)//Transposase GO:0006313//GO:0015074//GO:0007186 transposition, DNA-mediated//DNA integration//G-protein coupled receptor signaling pathway GO:0003677//GO:0004930 DNA binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.52853 BP_3 16.20 0.33 2685 478254777 ENN75013.1 727 8.7e-74 hypothetical protein YQE_08329, partial [Dendroctonus ponderosae] -- -- -- -- -- K11536 SLC28A pyrimidine nucleoside transport protein http://www.genome.jp/dbget-bin/www_bget?ko:K11536 Q62773 425 3.8e-40 Sodium/nucleoside cotransporter 2 OS=Rattus norvegicus GN=Slc28a2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3747 Concentrative Na+-nucleoside cotransporter CNT1/CNT2 Cluster-8309.52856 BP_3 20.07 1.80 829 170028319 XP_001842043.1 190 5.0e-12 conserved hypothetical protein [Culex quinquefasciatus]>gi|167874198|gb|EDS37581.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52857 BP_3 36.78 0.56 3467 642920402 XP_008192333.1 397 2.1e-35 PREDICTED: uncharacterized protein LOC664268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52858 BP_3 33.00 1.45 1390 189234546 XP_001815475.1 1116 3.5e-119 PREDICTED: lachesin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24372 136 6.3e-07 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895//PF00620 Immunoglobulin domain//RhoGAP domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.52863 BP_3 6.63 0.52 906 478257549 ENN77703.1 470 1.9e-44 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 169 6.1e-11 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.52864 BP_3 258.51 4.33 3166 642910366 XP_008200294.1 3475 0.0e+00 PREDICTED: myosin-IB [Tribolium castaneum]>gi|270014945|gb|EFA11393.1| hypothetical protein TcasGA2_TC011553 [Tribolium castaneum] 637314166 XM_008113233.1 58 8.21479e-19 PREDICTED: Anolis carolinensis myosin ID (myo1d), transcript variant X2, mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23979 2752 6.5e-310 Myosin-IB OS=Drosophila melanogaster GN=Myo61F PE=1 SV=3 PF06017//PF00612//PF00063 Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Myosin head (motor domain) -- -- GO:0005524//GO:0003774//GO:0005515 ATP binding//motor activity//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.52867 BP_3 372.71 5.51 3552 91080057 XP_973322.1 1495 1.0e-162 PREDICTED: GDP-mannose 4,6 dehydratase [Tribolium castaneum]>gi|270004634|gb|EFA01082.1| hypothetical protein TcasGA2_TC004005 [Tribolium castaneum] -- -- -- -- -- K01711 gmd, GMDS GDPmannose 4,6-dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01711 Q9VMW9 1339 5.1e-146 GDP-mannose 4,6 dehydratase OS=Drosophila melanogaster GN=Gmd PE=1 SV=2 PF01370 NAD dependent epimerase/dehydratase family GO:0019673//GO:0009298//GO:0006012//GO:0006000 GDP-mannose metabolic process//GDP-mannose biosynthetic process//galactose metabolic process//fructose metabolic process GO:0003824//GO:0050662//GO:0008446//GO:0000166 catalytic activity//coenzyme binding//GDP-mannose 4,6-dehydratase activity//nucleotide binding GO:0005622 intracellular KOG1372 GDP-mannose 4,6 dehydratase Cluster-8309.52869 BP_3 47.86 0.92 2811 91080613 XP_974147.1 1046 9.3e-111 PREDICTED: exosome complex component rrp45 [Tribolium castaneum]>gi|270005510|gb|EFA01958.1| hypothetical protein TcasGA2_TC007574 [Tribolium castaneum] 242003302 XM_002422642.1 81 1.19312e-31 Pediculus humanus corporis histone deacetylase complex subunit SAP30, putative, mRNA K03678 RRP45, EXOSC9 exosome complex component RRP45 http://www.genome.jp/dbget-bin/www_bget?ko:K03678 Q4QR75 691 5.6e-71 Exosome complex component RRP45 OS=Rattus norvegicus GN=Exosc9 PE=2 SV=1 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.5287 BP_3 7.54 0.36 1299 478251917 ENN72355.1 384 2.5e-34 hypothetical protein YQE_10990, partial [Dendroctonus ponderosae] -- -- -- -- -- K13781 SLC7A8, LAT2 solute carrier family 7 (L-type amino acid transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13781 Q9N1Q4 241 3.9e-19 Large neutral amino acids transporter small subunit 2 OS=Oryctolagus cuniculus GN=SLC7A8 PE=1 SV=1 PF13520 Amino acid permease GO:0003333//GO:0006865 amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1287 Amino acid transporters Cluster-8309.52871 BP_3 528.81 3.14 8419 270015299 EFA11747.1 1763 2.0e-193 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2VWP9 594 3.0e-59 Protogenin OS=Rattus norvegicus GN=Prtg PE=2 SV=1 PF16656//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.52872 BP_3 49.20 0.59 4279 817078884 XP_012261830.1 2737 1.2e-306 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Athalia rosae] 170052083 XM_001862026.1 43 2.42761e-10 Culex quinquefasciatus multidrug resistance-associated protein 14, mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P14772 1288 5.1e-140 Bile pigment transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BPT1 PE=1 SV=2 PF00005//PF01416//PF00664//PF13304//PF01926 ABC transporter//tRNA pseudouridine synthase//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006810//GO:0055085//GO:0001522//GO:0009451 transport//transmembrane transport//pseudouridine synthesis//RNA modification GO:0005524//GO:0003723//GO:0042626//GO:0009982//GO:0016887//GO:0005525 ATP binding//RNA binding//ATPase activity, coupled to transmembrane movement of substances//pseudouridine synthase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.52875 BP_3 3.00 0.37 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52881 BP_3 11.19 0.72 1042 478255178 ENN75407.1 413 8.7e-38 hypothetical protein YQE_07958, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DAK4 165 2.1e-10 Fatty acid-binding protein 12 OS=Mus musculus GN=Fabp12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.52882 BP_3 120.81 5.42 1366 642936649 XP_008198523.1 1499 1.3e-163 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Tribolium castaneum]>gi|270013058|gb|EFA09506.1| hypothetical protein TcasGA2_TC011607 [Tribolium castaneum] -- -- -- -- -- K09458 fabF 3-oxoacyl- http://www.genome.jp/dbget-bin/www_bget?ko:K09458 Q0VCA7 1115 1.9e-120 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Bos taurus GN=OXSM PE=2 SV=1 PF00108 Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016740//GO:0016747 transferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.52885 BP_3 81.53 0.61 6760 189238206 XP_969047.2 3357 0.0e+00 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum] 512920866 XM_004929683.1 38 2.31429e-07 PREDICTED: Bombyx mori bumetanide-sensitive sodium-(potassium)-chloride cotransporter-like (LOC101736988), partial mRNA K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 2236 9.5e-250 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF13520//PF02786//PF00324//PF03522 Amino acid permease//Carbamoyl-phosphate synthase L chain, ATP binding domain//Amino acid permease//Solute carrier family 12 GO:0006865//GO:0055085//GO:0006810//GO:0003333//GO:0006811 amino acid transport//transmembrane transport//transport//amino acid transmembrane transport//ion transport GO:0005524//GO:0015171//GO:0005215 ATP binding//amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.52886 BP_3 35.90 0.37 4946 189238206 XP_969047.2 3357 0.0e+00 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum] 512920866 XM_004929683.1 38 1.69072e-07 PREDICTED: Bombyx mori bumetanide-sensitive sodium-(potassium)-chloride cotransporter-like (LOC101736988), partial mRNA K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 2236 7.0e-250 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF13520//PF00895//PF03522//PF00324 Amino acid permease//ATP synthase protein 8//Solute carrier family 12//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0015986//GO:0003333//GO:0006811//GO:0015992 transmembrane transport//amino acid transport//transport//ATP synthesis coupled proton transport//amino acid transmembrane transport//ion transport//proton transport GO:0015171//GO:0005215//GO:0015078 amino acid transmembrane transporter activity//transporter activity//hydrogen ion transmembrane transporter activity GO:0016020//GO:0000276 membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2083 Na+/K+ symporter Cluster-8309.52892 BP_3 566.80 5.21 5531 642919183 XP_008191772.1 2770 2.2e-310 PREDICTED: uncharacterized protein LOC103312580 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52896 BP_3 288.79 1.85 7832 642929402 XP_008195823.1 7413 0.0e+00 PREDICTED: unconventional myosin-Va isoform X2 [Tribolium castaneum] 766917087 XM_011503499.1 99 3.30337e-41 PREDICTED: Ceratosolen solmsi marchali unconventional myosin-Va (LOC105365325), mRNA K10357 MYO5 myosin V http://www.genome.jp/dbget-bin/www_bget?ko:K10357 Q9QYF3 4232 0.0e+00 Unconventional myosin-Va OS=Rattus norvegicus GN=Myo5a PE=1 SV=1 PF05902//PF01890//PF00612//PF00063//PF00584//PF11857//PF08437 4.1 protein C-terminal domain (CTD)//Cobalamin synthesis G C-terminus//IQ calmodulin-binding motif//Myosin head (motor domain)//SecE/Sec61-gamma subunits of protein translocation complex//Domain of unknown function (DUF3377)//Glycosyl transferase family 8 C-terminal GO:0009103//GO:0006605//GO:0006886//GO:0009236 lipopolysaccharide biosynthetic process//protein targeting//intracellular protein transport//cobalamin biosynthetic process GO:0005524//GO:0004222//GO:0005198//GO:0005515//GO:0003779//GO:0003774//GO:0008918 ATP binding//metalloendopeptidase activity//structural molecule activity//protein binding//actin binding//motor activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0016459//GO:0005856//GO:0016020 myosin complex//cytoskeleton//membrane KOG0160 Myosin class V heavy chain Cluster-8309.52897 BP_3 186.94 1.77 5377 270010527 EFA06975.1 6057 0.0e+00 hypothetical protein TcasGA2_TC009935 [Tribolium castaneum] 766917087 XM_011503499.1 99 2.26413e-41 PREDICTED: Ceratosolen solmsi marchali unconventional myosin-Va (LOC105365325), mRNA K10357 MYO5 myosin V http://www.genome.jp/dbget-bin/www_bget?ko:K10357 Q9QYF3 3426 0.0e+00 Unconventional myosin-Va OS=Rattus norvegicus GN=Myo5a PE=1 SV=1 PF06257//PF00612//PF00584//PF00063//PF01890//PF05902 Biofilm formation stimulator VEG//IQ calmodulin-binding motif//SecE/Sec61-gamma subunits of protein translocation complex//Myosin head (motor domain)//Cobalamin synthesis G C-terminus//4.1 protein C-terminal domain (CTD) GO:0006886//GO:0006605//GO:0042710//GO:0009236 intracellular protein transport//protein targeting//biofilm formation//cobalamin biosynthetic process GO:0005515//GO:0003779//GO:0005198//GO:0005524//GO:0003774 protein binding//actin binding//structural molecule activity//ATP binding//motor activity GO:0016459//GO:0005856//GO:0016020 myosin complex//cytoskeleton//membrane KOG0160 Myosin class V heavy chain Cluster-8309.52898 BP_3 427.02 31.65 942 478263101 ENN81494.1 294 4.9e-24 hypothetical protein YQE_02023, partial [Dendroctonus ponderosae]>gi|546675484|gb|ERL86669.1| hypothetical protein D910_04075 [Dendroctonus ponderosae] -- -- -- -- -- K13120 FAM32A protein FAM32A http://www.genome.jp/dbget-bin/www_bget?ko:K13120 B0JZ89 231 4.1e-18 Protein FAM32A OS=Xenopus tropicalis GN=fam32a PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3410 Conserved alpha-helical protein Cluster-8309.52899 BP_3 108.47 9.88 821 478263101 ENN81494.1 294 4.3e-24 hypothetical protein YQE_02023, partial [Dendroctonus ponderosae]>gi|546675484|gb|ERL86669.1| hypothetical protein D910_04075 [Dendroctonus ponderosae] -- -- -- -- -- K13120 FAM32A protein FAM32A http://www.genome.jp/dbget-bin/www_bget?ko:K13120 B0JZ89 231 3.6e-18 Protein FAM32A OS=Xenopus tropicalis GN=fam32a PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3410 Conserved alpha-helical protein Cluster-8309.529 BP_3 4.00 0.45 716 321457150 EFX68242.1 265 8.7e-21 hypothetical protein DAPPUDRAFT_93618 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q9R257 187 4.0e-13 Heme-binding protein 1 OS=Mus musculus GN=Hebp1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5290 BP_3 9.00 0.58 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52900 BP_3 16.10 1.13 979 478263101 ENN81494.1 294 5.1e-24 hypothetical protein YQE_02023, partial [Dendroctonus ponderosae]>gi|546675484|gb|ERL86669.1| hypothetical protein D910_04075 [Dendroctonus ponderosae] -- -- -- -- -- K13120 FAM32A protein FAM32A http://www.genome.jp/dbget-bin/www_bget?ko:K13120 B0JZ89 231 4.3e-18 Protein FAM32A OS=Xenopus tropicalis GN=fam32a PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3410 Conserved alpha-helical protein Cluster-8309.52905 BP_3 10.37 0.46 1385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52908 BP_3 13.46 0.36 2110 546676350 ERL87377.1 1897 1.5e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.3e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.52910 BP_3 56.00 1.03 2916 270003257 EEZ99704.1 1989 4.4e-220 hypothetical protein TcasGA2_TC002465 [Tribolium castaneum] 170061339 XM_001866158.1 38 9.91707e-08 Culex quinquefasciatus lysosomal alpha-mannosidase, mRNA K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 1437 1.8e-157 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF09261//PF07748//PF01074 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0004553//GO:0008270//GO:0015923//GO:0004559 hydrolase activity, hydrolyzing O-glycosyl compounds//zinc ion binding//mannosidase activity//alpha-mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.52911 BP_3 109.00 6.73 1072 270016479 EFA12925.1 311 6.0e-26 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00690 174 1.9e-11 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52912 BP_3 39.53 1.22 1858 807028462 XP_012157237.1 283 1.8e-22 PREDICTED: perlucin [Ceratitis capitata] -- -- -- -- -- -- -- -- -- P82596 192 2.7e-13 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4297 C-type lectin Cluster-8309.52913 BP_3 206.47 6.28 1877 807028462 XP_012157237.1 283 1.9e-22 PREDICTED: perlucin [Ceratitis capitata] -- -- -- -- -- -- -- -- -- P82596 192 2.7e-13 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4297 C-type lectin Cluster-8309.52914 BP_3 65.80 1.15 3057 642912407 XP_008199495.1 2146 2.9e-238 PREDICTED: liprin-alpha-1 isoform X13 [Tribolium castaneum] 642912406 XM_008201273.1 455 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X13, mRNA -- -- -- -- O75334 743 5.7e-77 Liprin-alpha-2 OS=Homo sapiens GN=PPFIA2 PE=1 SV=2 PF07536//PF02459 HWE histidine kinase//Adenoviral DNA terminal protein GO:0016310//GO:0006260 phosphorylation//DNA replication GO:0003677//GO:0004673 DNA binding//protein histidine kinase activity GO:0009365 protein histidine kinase complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.52917 BP_3 920.36 10.08 4691 576249472 AHH29250.1 3252 0.0e+00 Bedraggled-like protein [Leptinotarsa decemlineata] 576249471 KC713792.1 606 0 Leptinotarsa decemlineata Bedraggled-like protein mRNA, complete cds K05336 SLC6AN solute carrier family 6 (neurotransmitter transporter), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05336 Q99884 256 2.6e-20 Sodium-dependent proline transporter OS=Homo sapiens GN=SLC6A7 PE=2 SV=2 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.52923 BP_3 601.00 29.64 1269 642935282 XP_008197947.1 1110 1.6e-118 PREDICTED: malectin-B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8AVF4 670 6.9e-69 Malectin-B OS=Xenopus laevis GN=mlec-b PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3593 Predicted receptor-like serine/threonine kinase Cluster-8309.52924 BP_3 2.00 0.77 416 642935282 XP_008197947.1 202 1.0e-13 PREDICTED: malectin-B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14165 133 4.2e-07 Malectin OS=Homo sapiens GN=MLEC PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52925 BP_3 48.58 0.75 3430 642939832 XP_008190719.1 290 5.3e-23 PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum]>gi|642939834|ref|XP_008190783.1| PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYP4 169 2.3e-10 Zinc finger C2HC domain-containing protein 1C OS=Rattus norvegicus GN=Zc2hc1c PE=2 SV=1 PF06689 ClpX C4-type zinc finger -- -- GO:0008270//GO:0046983 zinc ion binding//protein dimerization activity -- -- KOG3940 Uncharacterized conserved protein Cluster-8309.52928 BP_3 80.55 0.64 6371 270015748 EFA12196.1 1249 6.1e-134 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 653 3.2e-66 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665//PF11468//PF02156//PF13013 Integrase core domain//Integrase core domain//Aromatic prenyltransferase Orf2//Glycosyl hydrolase family 26//F-box-like domain GO:0015074//GO:0005975 DNA integration//carbohydrate metabolic process GO:0004553//GO:0016740//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//transferase activity//protein binding -- -- -- -- Cluster-8309.5293 BP_3 4.00 0.39 790 817196090 XP_012273615.1 159 1.9e-08 PREDICTED: piggyBac transposable element-derived protein 4-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52932 BP_3 163.93 4.45 2067 91082233 XP_972708.1 1766 2.2e-194 PREDICTED: 2',5'-phosphodiesterase 12 [Tribolium castaneum]>gi|270007451|gb|EFA03899.1| hypothetical protein TcasGA2_TC014029 [Tribolium castaneum] 752886955 XM_011263028.1 45 8.99027e-12 PREDICTED: Camponotus floridanus 2',5'-phosphodiesterase 12-like (LOC105254385), partial mRNA K19612 PDE12 2',5'-phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19612 Q6AXQ5 989 1.2e-105 2',5'-phosphodiesterase 12 OS=Rattus norvegicus GN=Pde12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.52936 BP_3 258.84 3.58 3774 91091180 XP_971767.1 1087 2.2e-115 PREDICTED: uncharacterized protein LOC660444 [Tribolium castaneum]>gi|270013120|gb|EFA09568.1| hypothetical protein TcasGA2_TC011682 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VCH8 313 5.1e-27 Transmembrane protein 65 OS=Bos taurus GN=TMEM65 PE=2 SV=1 PF01293 Phosphoenolpyruvate carboxykinase GO:0015976//GO:0006099//GO:0006094 carbon utilization//tricarboxylic acid cycle//gluconeogenesis GO:0005524//GO:0004612 ATP binding//phosphoenolpyruvate carboxykinase (ATP) activity -- -- KOG4619 Uncharacterized conserved protein Cluster-8309.52937 BP_3 8.85 1.34 609 675366188 KFM59090.1 217 2.7e-15 Hemocyte protein-glutamine gamma-glutamyltransferase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q05187 129 1.8e-06 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868 Transglutaminase family GO:0018149 peptide cross-linking -- -- -- -- -- -- Cluster-8309.5294 BP_3 50.69 11.78 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52940 BP_3 487.28 4.71 5273 478251798 ENN72244.1 2578 4.0e-288 hypothetical protein YQE_11107, partial [Dendroctonus ponderosae] 642923087 XM_967659.3 120 4.70462e-53 PREDICTED: Tribolium castaneum hemocyte protein-glutamine gamma-glutamyltransferase (LOC661504), mRNA K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 Q05187 1770 8.1e-196 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00927//PF00868 Transglutaminase family, C-terminal ig like domain//Transglutaminase family GO:0018149 peptide cross-linking GO:0003810 protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.52943 BP_3 23.43 0.49 2580 478252154 ENN72582.1 944 5.8e-99 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 P48760 690 6.7e-71 Folylpolyglutamate synthase, mitochondrial OS=Mus musculus GN=Fpgs PE=1 SV=3 PF08245//PF02023 Mur ligase middle domain//SCAN domain GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0005524//GO:0003700 ATP binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2525 Folylpolyglutamate synthase Cluster-8309.52944 BP_3 47.82 0.94 2741 642917105 XP_008191117.1 1121 1.8e-119 PREDICTED: trimethylguanosine synthase isoform X3 [Tribolium castaneum] -- -- -- -- -- K14292 TGS1 trimethylguanosine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14292 Q923W1 629 8.5e-64 Trimethylguanosine synthase OS=Mus musculus GN=Tgs1 PE=1 SV=2 PF02086//PF05401//PF03602//PF01596//PF09452//PF02005//PF03721//PF09445//PF08241//PF01795//PF05175 D12 class N6 adenine-specific DNA methyltransferase//Nodulation protein S (NodS)//Conserved hypothetical protein 95//O-methyltransferase//ESCRT-I subunit Mvb12//N2,N2-dimethylguanosine tRNA methyltransferase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//RNA cap guanine-N2 methyltransferase//Methyltransferase domain//MraW methylase family//Methyltransferase small domain GO:0009452//GO:0008152//GO:0001510//GO:0006306//GO:0009877//GO:0009451//GO:0032509//GO:0031167//GO:0032775//GO:0009312//GO:0055114//GO:0008033 7-methylguanosine RNA capping//metabolic process//RNA methylation//DNA methylation//nodulation//RNA modification//endosome transport via multivesicular body sorting pathway//rRNA methylation//DNA methylation on adenine//oligosaccharide biosynthetic process//oxidation-reduction process//tRNA processing GO:0051287//GO:0043130//GO:0003723//GO:0008171//GO:0008757//GO:0016616//GO:0009007//GO:0004809//GO:0008168 NAD binding//ubiquitin binding//RNA binding//O-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//site-specific DNA-methyltransferase (adenine-specific) activity//tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity GO:0000813 ESCRT I complex KOG2730 Methylase Cluster-8309.52946 BP_3 84.11 0.89 4824 641658101 XP_008180597.1 595 3.2e-58 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 544 1.1e-53 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF02892//PF13912//PF00400//PF16622//PF07776//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//WD domain, G-beta repeat//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0008270//GO:0005515//GO:0046872 DNA binding//zinc ion binding//protein binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.5295 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52951 BP_3 1.00 1.40 313 270004866 EFA01314.1 176 7.9e-11 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 137 1.1e-07 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 PF14672 Late cornified envelope GO:0008544 epidermis development -- -- -- -- -- -- Cluster-8309.52952 BP_3 18.30 0.36 2731 195488344 XP_002092274.1 496 5.4e-47 GE11757 [Drosophila yakuba]>gi|194178375|gb|EDW91986.1| GE11757 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- Q9GQQ0 248 1.3e-19 Protein spinster OS=Drosophila melanogaster GN=spin PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1330 Sugar transporter/spinster transmembrane protein Cluster-8309.52954 BP_3 407.03 4.88 4313 642919433 XP_008191867.1 1035 2.7e-109 PREDICTED: uncharacterized protein LOC663349 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09197//PF04272 Rap1, DNA-binding//Phospholamban GO:0006816//GO:0006810 calcium ion transport//transport GO:0003677//GO:0005246//GO:0042030 DNA binding//calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.52955 BP_3 104.26 1.70 3256 91088973 XP_966480.1 3004 0.0e+00 PREDICTED: G protein-coupled receptor kinase 1 [Tribolium castaneum]>gi|270011553|gb|EFA08001.1| hypothetical protein TcasGA2_TC005590 [Tribolium castaneum] 642932569 XM_961387.2 783 0 PREDICTED: Tribolium castaneum G protein-coupled receptor kinase 1 (LOC654946), mRNA K00910 ADRBK, GRK beta-adrenergic-receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00910 P32865 2673 9.7e-301 G protein-coupled receptor kinase 1 OS=Drosophila melanogaster GN=Gprk1 PE=2 SV=2 PF07714//PF00069//PF06293//PF01160 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Vertebrate endogenous opioids neuropeptide GO:0038032//GO:0009069//GO:0006468//GO:0016310//GO:0007218 termination of G-protein coupled receptor signaling pathway//serine family amino acid metabolic process//protein phosphorylation//phosphorylation//neuropeptide signaling pathway GO:0005524//GO:0016773//GO:0004703//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//G-protein coupled receptor kinase activity//protein kinase activity GO:0016020 membrane KOG0986 G protein-coupled receptor kinase Cluster-8309.52957 BP_3 196.61 2.76 3731 642919697 XP_008192026.1 4256 0.0e+00 PREDICTED: putative ATP-dependent RNA helicase DHX57 [Tribolium castaneum]>gi|270005433|gb|EFA01881.1| hypothetical protein TcasGA2_TC007486 [Tribolium castaneum] -- -- -- -- -- K13026 DHX57 ATP-dependent RNA helicase DHX57 http://www.genome.jp/dbget-bin/www_bget?ko:K13026 Q6P158 2470 3.9e-277 Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens GN=DHX57 PE=1 SV=2 PF00005//PF05773//PF00642//PF04408//PF00270//PF00437 ABC transporter//RWD domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Helicase associated domain (HA2)//DEAD/DEAH box helicase//Type II/IV secretion system protein GO:0006810 transport GO:0046872//GO:0008270//GO:0016887//GO:0003676//GO:0008026//GO:0005515//GO:0004386//GO:0005524 metal ion binding//zinc ion binding//ATPase activity//nucleic acid binding//ATP-dependent helicase activity//protein binding//helicase activity//ATP binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.52958 BP_3 95.56 6.23 1031 332376963 AEE63621.1 661 1.5e-66 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13220 WBP4, FBP21 WW domain-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13220 Q5HZF2 177 8.2e-12 WW domain-binding protein 4 OS=Rattus norvegicus GN=Wbp4 PE=2 SV=1 PF00397//PF06220 WW domain//U1 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0150 Spliceosomal protein FBP21 Cluster-8309.52959 BP_3 4.52 0.40 840 91081197 XP_975607.1 293 5.8e-24 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270005269|gb|EFA01717.1| hypothetical protein TcasGA2_TC007297 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5296 BP_3 3.31 0.36 734 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52960 BP_3 28.23 0.55 2772 91079660 XP_966451.1 2210 9.8e-246 PREDICTED: ubiquitin conjugation factor E4 A [Tribolium castaneum]>gi|270003363|gb|EEZ99810.1| hypothetical protein TcasGA2_TC002590 [Tribolium castaneum] -- -- -- -- -- K10596 UBE4A ubiquitin conjugation factor E4 A http://www.genome.jp/dbget-bin/www_bget?ko:K10596 A5PKG6 937 1.7e-99 Ubiquitin conjugation factor E4 A OS=Bos taurus GN=UBE4A PE=2 SV=1 PF10408 Ubiquitin elongating factor core GO:0006511//GO:0044267//GO:0016567 ubiquitin-dependent protein catabolic process//cellular protein metabolic process//protein ubiquitination GO:0004842//GO:0034450 ubiquitin-protein transferase activity//ubiquitin-ubiquitin ligase activity GO:0000151 ubiquitin ligase complex KOG2042 Ubiquitin fusion degradation protein-2 Cluster-8309.52962 BP_3 134.00 3.97 1919 642920137 XP_008192221.1 399 6.7e-36 PREDICTED: zinc finger protein weckle-like [Tribolium castaneum]>gi|270005306|gb|EFA01754.1| hypothetical protein TcasGA2_TC007352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08875 128 7.4e-06 Protein suppressor of hairy wing OS=Drosophila ananassae GN=su(Hw) PE=2 SV=1 PF02892//PF13465//PF00096 BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.52964 BP_3 2.00 2.24 325 642926387 XP_008194904.1 173 1.8e-10 PREDICTED: centromere-associated protein E-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52967 BP_3 1458.73 51.12 1667 499140776 AGL76355.1 420 2.2e-38 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 261 2.4e-21 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52969 BP_3 92.27 4.16 1361 91079626 XP_967654.1 1329 6.9e-144 PREDICTED: 28S ribosomal protein S29, mitochondrial [Tribolium castaneum]>gi|270004472|gb|EFA00920.1| hypothetical protein TcasGA2_TC003826 [Tribolium castaneum] -- -- -- -- -- K17408 DAP3, MRPS29 small subunit ribosomal protein S29 http://www.genome.jp/dbget-bin/www_bget?ko:K17408 P82922 749 5.1e-78 28S ribosomal protein S29, mitochondrial OS=Bos taurus GN=DAP3 PE=1 SV=3 PF04659 Archaeal flagella protein GO:0006915//GO:0097588 apoptotic process//archaeal or bacterial-type flagellum-dependent cell motility -- -- GO:0005761//GO:0015935 mitochondrial ribosome//small ribosomal subunit KOG3928 Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3 Cluster-8309.52974 BP_3 83.88 2.80 1737 642919693 XP_008192024.1 250 1.2e-18 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0JKV1 129 5.1e-06 Potassium channel AKT1 OS=Oryza sativa subsp. japonica GN=AKT1 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52977 BP_3 65.42 0.94 3660 642922790 XP_008193326.1 872 1.8e-90 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 469 4.0e-45 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 PF08923 Mitogen-activated protein kinase kinase 1 interacting GO:0032006 regulation of TOR signaling -- -- -- -- -- -- Cluster-8309.52981 BP_3 31.77 0.58 2935 805765285 XP_012134962.1 832 6.4e-86 PREDICTED: peptidyl-prolyl cis-trans isomerase cyp11 isoform X2 [Megachile rotundata] 645259408 XM_008237125.1 62 4.54687e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 O55035 612 8.5e-62 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.52983 BP_3 4.00 0.31 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52987 BP_3 39.57 0.79 2700 557160153 CDJ27266.1 145 2.7e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.2e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52988 BP_3 183.00 3.08 3159 557160153 CDJ27266.1 145 3.2e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.4e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52990 BP_3 29.06 0.52 2971 557160153 CDJ27266.1 145 3.0e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.3e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52991 BP_3 405.00 23.34 1128 546678608 ERL89190.1 666 4.3e-67 hypothetical protein D910_06564 [Dendroctonus ponderosae] -- -- -- -- -- K00943 tmk, DTYMK dTMP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00943 P97930 524 5.2e-52 Thymidylate kinase OS=Mus musculus GN=Dtymk PE=2 SV=2 PF01637 Archaeal ATPase -- -- GO:0005524 ATP binding -- -- KOG3327 Thymidylate kinase/adenylate kinase Cluster-8309.52993 BP_3 429.23 5.13 4324 189236304 XP_975050.2 1063 1.5e-112 PREDICTED: alkaline phosphatase 4 [Tribolium castaneum]>gi|270005478|gb|EFA01926.1| hypothetical protein TcasGA2_TC007539 [Tribolium castaneum] 642919537 XM_969957.3 61 2.41889e-20 PREDICTED: Tribolium castaneum alkaline phosphatase 4 (LOC663929), mRNA K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 Q24238 697 1.7e-71 Alkaline phosphatase 4 OS=Drosophila melanogaster GN=Aph-4 PE=2 SV=3 PF00245//PF01676 Alkaline phosphatase//Metalloenzyme superfamily GO:0008152 metabolic process GO:0016791//GO:0046872//GO:0016787//GO:0003824 phosphatase activity//metal ion binding//hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.52999 BP_3 151.72 1.25 6164 478260037 ENN79822.1 2213 9.8e-246 hypothetical protein YQE_03645, partial [Dendroctonus ponderosae] 642918140 XM_008193162.1 193 1.44639e-93 PREDICTED: Tribolium castaneum ATP-dependent DNA helicase Q4 (LOC655929), mRNA K10730 RECQL4 ATP-dependent DNA helicase Q4 http://www.genome.jp/dbget-bin/www_bget?ko:K10730 Q75NR7 1081 7.4e-116 ATP-dependent DNA helicase Q4 OS=Mus musculus GN=Recql4 PE=2 SV=2 PF00270//PF00485//PF00503//PF06414//PF02367//PF03193//PF00437//PF00098 DEAD/DEAH box helicase//Phosphoribulokinase / Uridine kinase family//G-protein alpha subunit//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//Type II/IV secretion system protein//Zinc knuckle GO:0008152//GO:0007165//GO:0006810//GO:0007186//GO:0002949 metabolic process//signal transduction//transport//G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification GO:0031683//GO:0005524//GO:0003924//GO:0019001//GO:0004871//GO:0016301//GO:0003676//GO:0008270//GO:0005525 G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//guanyl nucleotide binding//signal transducer activity//kinase activity//nucleic acid binding//zinc ion binding//GTP binding -- -- KOG0351 ATP-dependent DNA helicase Cluster-8309.53001 BP_3 112.36 0.82 6921 642920242 XP_008192264.1 3133 0.0e+00 PREDICTED: uncharacterized protein CG43867 isoform X2 [Tribolium castaneum] 194768448 XM_001966288.1 67 1.79343e-23 Drosophila ananassae GF22056 (Dana\GF22056), mRNA -- -- -- -- Q9W5D0 1421 3.1e-155 Uncharacterized protein CG43867 OS=Drosophila melanogaster GN=CG43867 PE=1 SV=4 PF00784//PF05864 MyTH4 domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005856//GO:0005730 cytoskeleton//nucleolus KOG0248 Cytoplasmic protein Max-1, contains PH, MyTH4 and FERM domains Cluster-8309.53002 BP_3 540.69 6.74 4157 642912795 XP_008201255.1 1623 1.7e-177 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 353 1.3e-31 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.53007 BP_3 293.15 5.72 2760 189240093 XP_972388.2 784 2.2e-80 PREDICTED: myosin heavy chain, clone 203 isoform X1 [Tribolium castaneum]>gi|270012237|gb|EFA08685.1| hypothetical protein TcasGA2_TC006355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53011 BP_3 100.74 3.93 1528 270010329 EFA06777.1 847 6.0e-88 hypothetical protein TcasGA2_TC009713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BRG8 350 1.1e-31 Transmembrane protein 209 OS=Mus musculus GN=Tmem209 PE=2 SV=1 PF02602 Uroporphyrinogen-III synthase HemD GO:0033014//GO:0006783//GO:0015994 tetrapyrrole biosynthetic process//heme biosynthetic process//chlorophyll metabolic process GO:0004852 uroporphyrinogen-III synthase activity -- -- KOG4670 Uncharacterized conserved membrane protein Cluster-8309.53014 BP_3 102.23 2.55 2226 795017626 XP_011858919.1 264 3.5e-20 PREDICTED: uncharacterized protein LOC105556435, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53015 BP_3 16.21 0.46 1986 642921155 XP_975421.2 1115 6.6e-119 PREDICTED: nitrilase and fragile histidine triad fusion protein NitFhit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76464 826 8.8e-87 Nitrilase and fragile histidine triad fusion protein NitFhit OS=Drosophila melanogaster GN=NitFhit PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0807 Carbon-nitrogen hydrolase Cluster-8309.53017 BP_3 17.00 1.06 1063 642927984 XP_008195472.1 432 5.6e-40 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53018 BP_3 57.90 0.82 3694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53020 BP_3 8.12 0.49 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17097//PF06416 Spindle pole body component//Protein of unknown function (DUF1076) GO:0072519//GO:0016567 parasitism//protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0000775 chromosome, centromeric region -- -- Cluster-8309.53022 BP_3 211.93 10.09 1304 91078772 XP_966771.1 870 1.1e-90 PREDICTED: mitochondrial import receptor subunit TOM40 homolog 1 [Tribolium castaneum]>gi|270004110|gb|EFA00558.1| hypothetical protein TcasGA2_TC003426 [Tribolium castaneum] -- -- -- -- -- K11518 TOM40 mitochondrial import receptor subunit TOM40 http://www.genome.jp/dbget-bin/www_bget?ko:K11518 Q9U4L6 631 2.4e-64 Mitochondrial import receptor subunit TOM40 homolog 1 OS=Drosophila melanogaster GN=Tom40 PE=2 SV=2 PF01459 Eukaryotic porin GO:0006820//GO:0044070//GO:0055085 anion transport//regulation of anion transport//transmembrane transport GO:0008308 voltage-gated anion channel activity GO:0005741 mitochondrial outer membrane KOG3296 Translocase of outer mitochondrial membrane complex, subunit TOM40 Cluster-8309.53025 BP_3 87.70 1.59 2954 270001480 EEZ97927.1 555 8.5e-54 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H5L6 192 4.3e-13 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF01082//PF05485 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//THAP domain GO:0055114 oxidation-reduction process GO:0016715//GO:0004497//GO:0005507//GO:0003676 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity//copper ion binding//nucleic acid binding -- -- -- -- Cluster-8309.53027 BP_3 29.00 0.48 3198 270001177 EEZ97624.1 187 4.3e-11 hypothetical protein TcasGA2_TC016072 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01785 Closterovirus coat protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.53028 BP_3 162.60 10.50 1038 546678378 ERL89011.1 847 4.1e-88 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 713 5.8e-74 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3936 Nitroreductases Cluster-8309.53030 BP_3 4.02 0.39 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53031 BP_3 513.72 4.89 5357 91094623 XP_969159.1 2619 7.1e-293 PREDICTED: SCY1-like protein 2 [Tribolium castaneum]>gi|270016433|gb|EFA12879.1| hypothetical protein TcasGA2_TC011557 [Tribolium castaneum] -- -- -- -- -- K17541 SCYL2 SCY1-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17541 Q6P3W7 1760 1.2e-194 SCY1-like protein 2 OS=Homo sapiens GN=SCYL2 PE=1 SV=1 PF00069//PF07776//PF07714//PF00096//PF16622//PF02985//PF13912//PF13465 Protein kinase domain//Zinc-finger associated domain (zf-AD)//Protein tyrosine kinase//Zinc finger, C2H2 type//zinc-finger C2H2-type//HEAT repeat//C2H2-type zinc finger//Zinc-finger double domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0046872//GO:0005524//GO:0008270 protein binding//protein kinase activity//metal ion binding//ATP binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.53032 BP_3 117.00 1.53 3976 642926686 XP_008194968.1 2084 5.7e-231 PREDICTED: optomotor-blind protein [Tribolium castaneum] 642926685 XM_008196746.1 616 0 PREDICTED: Tribolium castaneum optomotor-blind-like (LOC661159), mRNA K10177 TBX3 T-box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10177 Q24432 1174 7.8e-127 Optomotor-blind protein OS=Drosophila melanogaster GN=bi PE=1 SV=3 PF00907//PF00018//PF06624 T-box//SH3 domain//Ribosome associated membrane protein RAMP4 GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005515 transcription factor activity, sequence-specific DNA binding//protein binding GO:0005783//GO:0005667//GO:0005634 endoplasmic reticulum//transcription factor complex//nucleus KOG3585 TBX2 and related T-box transcription factors Cluster-8309.53035 BP_3 13.00 0.80 1079 546678393 ERL89023.1 471 1.7e-44 hypothetical protein D910_06401 [Dendroctonus ponderosae] 642934684 XM_008199547.1 110 3.40252e-48 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF17076 SBE2, cell-qall formation GO:0031505 fungal-type cell wall organization -- -- -- -- -- -- Cluster-8309.5304 BP_3 4.00 0.40 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53043 BP_3 91.24 0.77 6030 189240296 XP_973610.2 2451 2.4e-273 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 P55156 752 1.0e-77 Microsomal triglyceride transfer protein large subunit (Fragment) OS=Bos taurus GN=MTTP PE=1 SV=1 PF01347//PF00019//PF09172 Lipoprotein amino terminal region//Transforming growth factor beta like domain//Domain of unknown function (DUF1943) GO:0007165//GO:0040007//GO:0008283//GO:0006869 signal transduction//growth//cell proliferation//lipid transport GO:0008083//GO:0005319 growth factor activity//lipid transporter activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.53045 BP_3 156.82 4.11 2132 642930929 XP_008196145.1 2008 2.0e-222 PREDICTED: ephrin type-B receptor 1-B isoform X1 [Tribolium castaneum] 642930930 XM_008197924.1 296 2.73726e-151 PREDICTED: Tribolium castaneum ephrin type-A receptor 4-B (LOC658635), transcript variant X2, mRNA K05110 EPHB1, ELK, NET Eph receptor B1 http://www.genome.jp/dbget-bin/www_bget?ko:K05110 P28693 772 1.7e-80 Ephrin type-B receptor 2 OS=Gallus gallus GN=EPHB2 PE=1 SV=3 PF01404//PF00041//PF16656 Ephrin receptor ligand binding domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0048013//GO:0006771//GO:0019497 ephrin receptor signaling pathway//riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.53047 BP_3 188.76 2.91 3417 546674875 ERL86161.1 2709 1.7e-303 hypothetical protein D910_03574 [Dendroctonus ponderosae] -- -- -- -- -- K12796 ERBB2IP, ERBIN erbb2-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12796 Q9V780 825 2.0e-86 Protein lap1 OS=Drosophila melanogaster GN=Lap1 PE=2 SV=1 PF13855//PF00560//PF00595//PF13180 Leucine rich repeat//Leucine Rich Repeat//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.53048 BP_3 81.00 3.63 1367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53050 BP_3 23.00 0.45 2753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53052 BP_3 101.29 1.72 3125 189235122 XP_001811652.1 2865 0.0e+00 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 412 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1564 3.7e-172 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF00856//PF01496//PF05602 SET domain//V-type ATPase 116kDa subunit family//Cleft lip and palate transmembrane protein 1 (CLPTM1) GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0003682//GO:0005515 hydrogen ion transmembrane transporter activity//chromatin binding//protein binding GO:0033179//GO:0016021//GO:0000785 proton-transporting V-type ATPase, V0 domain//integral component of membrane//chromatin KOG1079 Transcriptional repressor EZH1 Cluster-8309.53053 BP_3 114.00 2.98 2136 642911027 XP_008193514.1 1859 3.8e-205 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7G192 756 1.2e-78 Indole-3-acetaldehyde oxidase OS=Arabidopsis thaliana GN=AAO2 PE=1 SV=2 PF00123//PF00941//PF01799//PF06056//PF00111 Peptide hormone//FAD binding domain in molybdopterin dehydrogenase//[2Fe-2S] binding domain//Putative ATPase subunit of terminase (gpP-like)//2Fe-2S iron-sulfur cluster binding domain GO:0006118//GO:0019069//GO:0055114//GO:0007165 obsolete electron transport//viral capsid assembly//oxidation-reduction process//signal transduction GO:0009055//GO:0051536//GO:0046872//GO:0005524//GO:0005179//GO:0016491 electron carrier activity//iron-sulfur cluster binding//metal ion binding//ATP binding//hormone activity//oxidoreductase activity GO:0005576 extracellular region -- -- Cluster-8309.53057 BP_3 1.00 0.38 419 157129316 XP_001655365.1 163 3.4e-09 AAEL002467-PA [Aedes aegypti]>gi|108882100|gb|EAT46325.1| AAEL002467-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF00020 Chitin binding Peritrophin-A domain//TNFR/NGFR cysteine-rich region GO:0006030 chitin metabolic process GO:0008061//GO:0005515 chitin binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.53060 BP_3 81.13 1.31 3276 270001891 EEZ98338.1 345 2.1e-29 hypothetical protein TcasGA2_TC000792 [Tribolium castaneum] -- -- -- -- -- K08656 DPP9 dipeptidyl-peptidase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08656 Q8BVG4 253 4.0e-20 Dipeptidyl peptidase 9 OS=Mus musculus GN=Dpp9 PE=2 SV=2 PF00326 Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- KOG2281 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Cluster-8309.53063 BP_3 8.00 0.35 1401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53064 BP_3 13.00 9.13 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53065 BP_3 425.00 10.92 2167 820805572 AKG92777.1 698 1.6e-70 helix loop helix protein 3B [Leptinotarsa decemlineata] -- -- -- -- -- K09068 TAL T-cell acute lymphocytic leukemia protein http://www.genome.jp/dbget-bin/www_bget?ko:K09068 Q90YI8 262 2.4e-21 T-cell acute lymphocytic leukemia protein 1 OS=Takifugu rubripes GN=tal1 PE=2 SV=1 PF00010//PF06338 Helix-loop-helix DNA-binding domain//ComK protein GO:0030420 establishment of competence for transformation GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.53066 BP_3 30.86 2.01 1031 642940186 XP_008200539.1 953 2.1e-100 PREDICTED: uncharacterized protein LOC103314959 isoform X1 [Tribolium castaneum]>gi|642940188|ref|XP_008200548.1| PREDICTED: uncharacterized protein LOC103314959 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF13545 Transposase DDE domain//Crp-like helix-turn-helix domain GO:0006313//GO:0006355 transposition, DNA-mediated//regulation of transcription, DNA-templated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-8309.53067 BP_3 1.00 2.65 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53069 BP_3 8.01 0.36 1357 189236439 XP_001814289.1 1012 3.9e-107 PREDICTED: uncharacterized protein LOC100142575 [Tribolium castaneum]>gi|270005928|gb|EFA02376.1| hypothetical protein TcasGA2_TC008051 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53071 BP_3 1312.21 14.94 4524 795035143 XP_011864846.1 2194 1.1e-243 PREDICTED: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [Vollenhovia emeryi] 642933878 XM_008199327.1 658 0 PREDICTED: Tribolium castaneum protein phosphatase PP2A 55 kDa regulatory subunit (LOC659477), transcript variant X2, mRNA K04354 PPP2R2 serine/threonine-protein phosphatase 2A regulatory subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K04354 P36872 2065 4.3e-230 Protein phosphatase PP2A 55 kDa regulatory subunit OS=Drosophila melanogaster GN=tws PE=2 SV=1 PF11093//PF00400//PF13465//PF13463 Mitochondrial export protein Som1//WD domain, G-beta repeat//Zinc-finger double domain//Winged helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046872//GO:0003700 protein binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0042720//GO:0005667 mitochondrial inner membrane peptidase complex//transcription factor complex KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.53072 BP_3 7.42 0.34 1344 270011984 EFA08432.1 182 6.9e-11 hypothetical protein TcasGA2_TC006079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53076 BP_3 27.17 1.49 1169 642925968 XP_008194714.1 549 1.7e-53 PREDICTED: uncharacterized protein LOC655532 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53077 BP_3 706.03 16.71 2328 642925968 XP_008194714.1 817 2.8e-84 PREDICTED: uncharacterized protein LOC655532 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53081 BP_3 152.42 1.59 4915 478252864 ENN73253.1 1822 1.7e-200 hypothetical protein YQE_10149, partial [Dendroctonus ponderosae] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1237 4.8e-134 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.53082 BP_3 82.24 1.15 3728 642934335 XP_969733.2 2952 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X5 [Tribolium castaneum] 817086197 XM_012410395.1 92 1.21848e-37 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 419 2.6e-39 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF09815//PF01436//PF05524//PF14634//PF00643//PF00097//PF05929//PF01580//PF02601//PF13639//PF01637//PF05149 XK-related protein//NHL repeat//PEP-utilising enzyme, N-terminal//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger)//Phage capsid scaffolding protein (GPO) serine peptidase//FtsK/SpoIIIE family//Exonuclease VII, large subunit//Ring finger domain//Archaeal ATPase//Paraflagellar rod protein GO:0019069//GO:0006308//GO:0009401 viral capsid assembly//DNA catabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0046872//GO:0008270//GO:0000166//GO:0005515//GO:0008855//GO:0003677//GO:0005524//GO:0005516 metal ion binding//zinc ion binding//nucleotide binding//protein binding//exodeoxyribonuclease VII activity//DNA binding//ATP binding//calmodulin binding GO:0005622//GO:0009318//GO:0031514//GO:0016021 intracellular//exodeoxyribonuclease VII complex//motile cilium//integral component of membrane -- -- Cluster-8309.53091 BP_3 92.87 1.43 3423 817213310 XP_012282872.1 1421 3.7e-154 PREDICTED: POU domain, class 6, transcription factor 1 isoform X2 [Orussus abietinus] 817056495 XM_012413689.1 107 5.12764e-46 PREDICTED: Athalia rosae POU domain, class 6, transcription factor 1 (LOC105693636), mRNA K09368 POU6F POU domain transcription factor, class 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09368 Q8BJI4 671 1.4e-68 POU domain, class 6, transcription factor 2 OS=Mus musculus GN=Pou6f2 PE=2 SV=1 PF00157//PF00046 Pou domain - N-terminal to homeobox domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.53092 BP_3 2.00 1.09 378 642936148 XP_008198317.1 252 1.5e-19 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Tribolium castaneum] 571506739 XM_397111.4 36 1.5382e-07 PREDICTED: Apis mellifera f-box/LRR-repeat protein 2-like (LOC413670), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.531 BP_3 29.00 2.57 836 332374752 AEE62517.1 280 1.8e-22 unknown [Dendroctonus ponderosae]>gi|478256059|gb|ENN76258.1| hypothetical protein YQE_07223, partial [Dendroctonus ponderosae]>gi|546675990|gb|ERL87085.1| hypothetical protein D910_04486 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P49100 215 2.6e-16 Cytochrome b5 OS=Oryza sativa subsp. japonica GN=Os05g0108800 PE=2 SV=2 PF09187 Domain of unknown function(DUF1950) GO:0044030 regulation of DNA methylation -- -- GO:0005634 nucleus KOG0537 Cytochrome b5 Cluster-8309.53104 BP_3 16.77 0.71 1424 270008632 EFA05080.1 362 9.8e-32 hypothetical protein TcasGA2_TC015177 [Tribolium castaneum] 642925741 XM_008203345.1 66 1.30231e-23 PREDICTED: Tribolium castaneum protein strawberry notch (LOC655369), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53105 BP_3 14.00 1.25 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53106 BP_3 145.96 5.64 1540 642936624 XP_008198511.1 835 1.5e-86 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] 642936623 XM_008200289.1 118 1.74948e-52 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 188 6.5e-13 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF04513//PF08702//PF02346//PF03938 Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//Chordopoxvirus multifunctional envelope protein A27//Outer membrane protein (OmpH-like) GO:0030168//GO:0007165//GO:0051258//GO:0019064 platelet activation//signal transduction//protein polymerization//fusion of virus membrane with host plasma membrane GO:0030674//GO:0051082//GO:0005102//GO:0005198 protein binding, bridging//unfolded protein binding//receptor binding//structural molecule activity GO:0005577//GO:0019028//GO:0019031 fibrinogen complex//viral capsid//viral envelope -- -- Cluster-8309.53107 BP_3 12.00 0.57 1304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04879 Molybdopterin oxidoreductase Fe4S4 domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.5311 BP_3 5.50 0.39 976 642914660 XP_974035.2 503 3.0e-48 PREDICTED: transmembrane protein 230 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CIB6 284 3.1e-24 Transmembrane protein 230 OS=Mus musculus GN=Tmem230 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4753 Predicted membrane protein Cluster-8309.53113 BP_3 51.57 0.39 6720 270004778 EFA01226.1 1771 1.9e-194 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1242 1.7e-134 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF06657//PF12513//PF13683//PF00665 Centrosome microtubule-binding domain of Cep57//Mitochondrial degradasome RNA helicase subunit C terminal//Integrase core domain//Integrase core domain GO:0015074 DNA integration GO:0016817//GO:0008017 hydrolase activity, acting on acid anhydrides//microtubule binding GO:0045298 tubulin complex KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.53117 BP_3 81.13 0.99 4238 332376687 AEE63483.1 502 1.7e-47 unknown [Dendroctonus ponderosae]>gi|478259424|gb|ENN79314.1| hypothetical protein YQE_04223, partial [Dendroctonus ponderosae]>gi|546675165|gb|ERL86401.1| hypothetical protein D910_03808 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VWK6 326 1.8e-28 Post-GPI attachment to proteins factor 2-like OS=Drosophila melanogaster GN=CG7990 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG3979 FGF receptor activating protein 1 Cluster-8309.53118 BP_3 129.41 3.02 2355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53119 BP_3 66.59 2.94 1385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53120 BP_3 11.90 0.53 1376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53122 BP_3 7.00 0.51 951 795010007 XP_011864749.1 696 1.2e-70 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.53123 BP_3 6.94 0.32 1349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53126 BP_3 3.64 0.44 689 546675653 ERL86803.1 445 1.1e-41 hypothetical protein D910_04208 [Dendroctonus ponderosae] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 O08812 220 5.7e-17 Cationic amino acid transporter 3 OS=Rattus norvegicus GN=Slc7a3 PE=2 SV=1 PF03840//PF03419 Preprotein translocase SecG subunit//Sporulation factor SpoIIGA GO:0015031//GO:0030436//GO:0006508//GO:0009306 protein transport//asexual sporulation//proteolysis//protein secretion GO:0015450//GO:0004190 P-P-bond-hydrolysis-driven protein transmembrane transporter activity//aspartic-type endopeptidase activity GO:0009941//GO:0016021 chloroplast envelope//integral component of membrane KOG1286 Amino acid transporters Cluster-8309.53128 BP_3 581.89 19.19 1753 642926638 XP_008194951.1 1549 2.7e-169 PREDICTED: LOW QUALITY PROTEIN: DNA-binding protein Ets97D [Tribolium castaneum] -- -- -- -- -- K09441 GABPA GA-binding protein transcription factor, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K09441 Q04688 944 1.6e-100 DNA-binding protein Ets97D OS=Drosophila melanogaster GN=Ets97D PE=1 SV=2 PF02198//PF00178 Sterile alpha motif (SAM)/Pointed domain//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3806 Predicted transcription factor Cluster-8309.53129 BP_3 9.00 1.56 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5313 BP_3 91.16 1.79 2746 332374612 AEE62447.1 1251 1.5e-134 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q52KD1 756 1.6e-78 Sodium/bile acid cotransporter 7-B OS=Xenopus laevis GN=slc10a7-b PE=2 SV=1 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.53130 BP_3 104.25 9.49 821 546680452 ERL90718.1 468 2.9e-44 hypothetical protein D910_08065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16740 Spindle and kinetochore-associated protein 2 GO:0007059//GO:0031110//GO:0051301//GO:0007067//GO:0000090 chromosome segregation//regulation of microtubule polymerization or depolymerization//cell division//mitotic nuclear division//mitotic anaphase GO:0008017 microtubule binding GO:0005876//GO:0000940//GO:0045298 spindle microtubule//condensed chromosome outer kinetochore//tubulin complex -- -- Cluster-8309.53132 BP_3 13.74 0.87 1050 91094501 XP_971498.1 457 7.0e-43 PREDICTED: translation initiation factor eIF-2B subunit alpha [Tribolium castaneum]>gi|270000750|gb|EEZ97197.1| hypothetical protein TcasGA2_TC004385 [Tribolium castaneum] 749789948 XM_011149954.1 53 1.60584e-16 PREDICTED: Harpegnathos saltator translation initiation factor eIF-2B subunit alpha (LOC105188472), transcript variant X2, mRNA K03239 EIF2B1 translation initiation factor eIF-2B subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03239 Q0IIF2 334 5.2e-30 Translation initiation factor eIF-2B subunit alpha OS=Bos taurus GN=EIF2B1 PE=2 SV=1 PF01008//PF01380 Initiation factor 2 subunit family//SIS domain GO:0005975//GO:0044237 carbohydrate metabolic process//cellular metabolic process GO:0030246 carbohydrate binding -- -- KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) Cluster-8309.53133 BP_3 828.72 13.88 3169 91078858 XP_972061.1 1822 1.1e-200 PREDICTED: putative serine protease K12H4.7 [Tribolium castaneum] 642916112 XM_966968.2 67 8.1647e-24 PREDICTED: Tribolium castaneum putative serine protease K12H4.7 (LOC660762), mRNA -- -- -- -- P90893 781 2.3e-81 Putative serine protease F56F10.1 OS=Caenorhabditis elegans GN=F56F10.1 PE=1 SV=2 PF05577//PF02080//PF09138 Serine carboxypeptidase S28//TrkA-C domain//Urm1 (Ubiquitin related modifier) GO:0006812//GO:0034227//GO:0006508//GO:0006813 cation transport//tRNA thio-modification//proteolysis//potassium ion transport GO:0008324//GO:0008236 cation transmembrane transporter activity//serine-type peptidase activity GO:0005737 cytoplasm KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.53134 BP_3 300.89 5.15 3108 91086935 XP_972534.1 2270 1.2e-252 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1252 5.5e-136 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF05209//PF03193//PF02724//PF00664//PF01926//PF13304//PF00437 ABC transporter//Septum formation inhibitor MinC, N-terminal domain//Protein of unknown function, DUF258//CDC45-like protein//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Type II/IV secretion system protein GO:0009987//GO:0055085//GO:0051302//GO:0006270//GO:0006810 cellular process//transmembrane transport//regulation of cell division//DNA replication initiation//transport GO:0000166//GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 nucleotide binding//GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.53135 BP_3 61.19 1.08 3017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53136 BP_3 13.00 4.00 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53138 BP_3 3.00 1.01 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53139 BP_3 4.81 0.93 540 642928504 XP_008193818.1 448 4.0e-42 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2K6 154 2.0e-09 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53140 BP_3 87.69 1.11 4093 817061123 XP_012252151.1 255 7.2e-19 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53141 BP_3 2.00 1.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53142 BP_3 93.00 4.00 1413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53143 BP_3 191.76 3.11 3267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53144 BP_3 366.41 12.97 1653 546673009 ERL84695.1 319 1.1e-26 hypothetical protein D910_02121 [Dendroctonus ponderosae] -- -- -- -- -- K02435 gatC, GATC aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K02435 C3XVM1 244 2.2e-19 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Branchiostoma floridae GN=BRAFLDRAFT_270748 PE=3 SV=1 PF02686 Glu-tRNAGln amidotransferase C subunit GO:0006450 regulation of translational fidelity -- -- -- -- -- -- Cluster-8309.53145 BP_3 281.93 7.84 2025 642919000 XP_974493.2 1159 5.3e-124 PREDICTED: 1,5-anhydro-D-fructose reductase [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P45376 775 7.4e-81 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.53154 BP_3 12.57 0.57 1356 642933162 XP_974056.2 742 8.0e-76 PREDICTED: ubiquitin carboxyl-terminal hydrolase nonstop isoform X2 [Tribolium castaneum] -- -- -- -- -- K11366 USP22_27_51, UBP8 ubiquitin carboxyl-terminal hydrolase 22/27/51 http://www.genome.jp/dbget-bin/www_bget?ko:K11366 Q9VVR1 545 2.3e-54 Ubiquitin carboxyl-terminal hydrolase nonstop OS=Drosophila melanogaster GN=not PE=1 SV=3 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0036459//GO:0070140//GO:0032183 ubiquitinyl hydrolase activity//SUMO-specific isopeptidase activity//SUMO binding -- -- -- -- Cluster-8309.53155 BP_3 13.63 0.52 1545 642933164 XP_008197282.1 469 4.1e-44 PREDICTED: ubiquitin carboxyl-terminal hydrolase 22 isoform X3 [Tribolium castaneum] -- -- -- -- -- K11366 USP22_27_51, UBP8 ubiquitin carboxyl-terminal hydrolase 22/27/51 http://www.genome.jp/dbget-bin/www_bget?ko:K11366 Q9VVR1 313 2.1e-27 Ubiquitin carboxyl-terminal hydrolase nonstop OS=Drosophila melanogaster GN=not PE=1 SV=3 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1867 Ubiquitin-specific protease Cluster-8309.53157 BP_3 14.00 0.41 1922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02831 gpW GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.53161 BP_3 33.00 8.10 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53162 BP_3 16.54 2.49 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53164 BP_3 185.50 6.93 1581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53165 BP_3 40.46 3.00 941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53167 BP_3 368.61 1.50 12157 270016002 EFA12450.1 1111 1.2e-117 hypothetical protein TcasGA2_TC016185 [Tribolium castaneum]>gi|270016905|gb|EFA13351.1| hypothetical protein TcasGA2_TC006959 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 315 9.7e-27 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF02902//PF00665//PF01637//PF00770//PF08398//PF13683//PF02022 Ulp1 protease family, C-terminal catalytic domain//Integrase core domain//Archaeal ATPase//Adenovirus endoprotease//Parvovirus coat protein VP1//Integrase core domain//Integrase Zinc binding domain GO:0015074//GO:0006508 DNA integration//proteolysis GO:0005198//GO:0005524//GO:0004197//GO:0008234//GO:0008270 structural molecule activity//ATP binding//cysteine-type endopeptidase activity//cysteine-type peptidase activity//zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.53170 BP_3 5.00 1.60 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53171 BP_3 206.73 2.09 5070 546685821 ERL95264.1 1051 4.4e-111 hypothetical protein D910_12530 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843//PF04931//PF01080//PF02724 Herpesvirus tegument protein, N-terminal conserved region//DNA polymerase phi//Presenilin//CDC45-like protein GO:0006351//GO:0006270//GO:0006508//GO:0006260 transcription, DNA-templated//DNA replication initiation//proteolysis//DNA replication GO:0003677//GO:0004190//GO:0003887//GO:0008233 DNA binding//aspartic-type endopeptidase activity//DNA-directed DNA polymerase activity//peptidase activity GO:0016021//GO:0042575 integral component of membrane//DNA polymerase complex -- -- Cluster-8309.53174 BP_3 29.92 1.11 1587 642935122 XP_008197897.1 2108 3.8e-234 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 641668078 XM_008186100.1 34 8.94555e-06 PREDICTED: Acyrthosiphon pisum uncharacterized LOC100166039 (LOC100166039), mRNA -- -- -- -- P21783 262 1.8e-21 Neurogenic locus notch homolog protein 1 OS=Xenopus laevis GN=notch1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53175 BP_3 12.00 1.42 700 270013391 EFA09839.1 1069 5.0e-114 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 662193239 XM_008471296.1 76 1.72446e-29 PREDICTED: Diaphorina citri neurogenic locus notch homolog protein 3-like (LOC103506873), partial mRNA -- -- -- -- P97677 162 3.1e-10 Delta-like protein 1 OS=Rattus norvegicus GN=Dll1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53180 BP_3 949.62 5.15 9185 270006423 EFA02871.1 12307 0.0e+00 cadherin-like protein [Tribolium castaneum] 642919273 XM_965991.3 790 0 PREDICTED: Tribolium castaneum cadherin-related tumor suppressor (LOC659713), mRNA K16669 FAT4 protocadherin Fat 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16669 P33450 8565 0.0e+00 Cadherin-related tumor suppressor OS=Drosophila melanogaster GN=ft PE=1 SV=3 PF00008//PF00028 EGF-like domain//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.53184 BP_3 44.88 0.41 5611 478250833 ENN71323.1 1194 1.3e-127 hypothetical protein YQE_11983, partial [Dendroctonus ponderosae]>gi|478259213|gb|ENN79116.1| hypothetical protein YQE_04427, partial [Dendroctonus ponderosae] 642918718 XM_008193332.1 144 2.28119e-66 PREDICTED: Tribolium castaneum zinc finger protein jing homolog (LOC658276), transcript variant X2, mRNA K17452 AEBP2 zinc finger protein AEBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K17452 Q17PR1 641 7.0e-65 Zinc finger protein jing homolog OS=Aedes aegypti GN=AAEL000263 PE=3 SV=1 PF16622//PF05399//PF13465//PF00096 zinc-finger C2H2-type//Ectropic viral integration site 2A protein (EVI2A)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.53186 BP_3 61.61 0.46 6795 189242024 XP_967940.2 1531 1.3e-166 PREDICTED: sideroflexin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96NB2 1019 1.3e-108 Sideroflexin-2 OS=Homo sapiens GN=SFXN2 PE=1 SV=2 PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.53187 BP_3 526.26 5.34 5046 642924636 XP_008194372.1 1783 5.8e-196 PREDICTED: uncharacterized protein LOC103313276 [Tribolium castaneum]>gi|270007969|gb|EFA04417.1| hypothetical protein TcasGA2_TC014717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09111//PF00400//PF08082//PF03854 SLIDE//WD domain, G-beta repeat//PRO8NT (NUC069), PrP8 N-terminal domain//P-11 zinc finger GO:0000398//GO:0006338 mRNA splicing, via spliceosome//chromatin remodeling GO:0016818//GO:0003676//GO:0008270//GO:0005515//GO:0005524//GO:0003723 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//zinc ion binding//protein binding//ATP binding//RNA binding GO:0005634 nucleus -- -- Cluster-8309.53191 BP_3 25.00 4.61 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53192 BP_3 3.36 2.66 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53198 BP_3 2.00 2.69 315 646695674 KDR08438.1 172 2.3e-10 hypothetical protein L798_01785, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53200 BP_3 16.70 0.60 1644 826407464 XP_012543043.1 157 6.7e-08 PREDICTED: zinc finger protein 845-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- P0CG31 147 4.0e-08 Putative zinc finger protein 286B OS=Homo sapiens GN=ZNF286B PE=5 SV=1 PF00096//PF02892//PF05191 Zinc finger, C2H2 type//BED zinc finger//Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0003677//GO:0046872//GO:0004017 DNA binding//metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.53201 BP_3 28.68 0.87 1880 546681837 ERL91852.1 932 1.0e-97 hypothetical protein D910_09177 [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q9H936 575 1.1e-57 Mitochondrial glutamate carrier 1 OS=Homo sapiens GN=SLC25A22 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.53202 BP_3 69.44 0.98 3703 642939164 XP_008200361.1 2189 3.6e-243 PREDICTED: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1 [Tribolium castaneum]>gi|270016358|gb|EFA12804.1| hypothetical protein TcasGA2_TC001867 [Tribolium castaneum] 752875257 XM_011256672.1 68 2.65701e-24 PREDICTED: Camponotus floridanus alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC105250520), transcript variant X5, mRNA K00736 MGAT2 alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00736 Q921V5 843 1.8e-88 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat2 PE=2 SV=1 PF02367//PF01121//PF06414//PF05060//PF00437 Threonylcarbamoyl adenosine biosynthesis protein TsaE//Dephospho-CoA kinase//Zeta toxin//N-acetylglucosaminyltransferase II (MGAT2)//Type II/IV secretion system protein GO:0015937//GO:0002949//GO:0006810//GO:0009312//GO:0015940 coenzyme A biosynthetic process//tRNA threonylcarbamoyladenosine modification//transport//oligosaccharide biosynthetic process//pantothenate biosynthetic process GO:0004140//GO:0016301//GO:0008455//GO:0005524 dephospho-CoA kinase activity//kinase activity//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity//ATP binding GO:0005795//GO:0016021 Golgi stack//integral component of membrane KOG2791 N-acetylglucosaminyltransferase Cluster-8309.53204 BP_3 291.99 2.93 5097 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53205 BP_3 82.48 2.98 1626 728417366 AIY68341.1 1258 1.4e-135 putative pheromone esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 669 1.2e-68 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.53206 BP_3 4811.38 149.11 1847 728417366 AIY68341.1 1778 8.1e-196 putative pheromone esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 787 2.7e-82 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.53207 BP_3 641.00 8.36 3989 390362249 XP_001190749.2 1023 6.2e-108 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 735 6.3e-76 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF05349 Ankyrin repeat//Ankyrin repeat//GATA-type transcription activator, N-terminal GO:0045893 positive regulation of transcription, DNA-templated GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.53211 BP_3 150.02 6.51 1402 749774888 XP_011142643.1 213 1.8e-14 PREDICTED: uncharacterized protein LOC105185097 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53213 BP_3 67.99 4.40 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53214 BP_3 9.01 0.63 982 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53215 BP_3 44.00 6.81 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53216 BP_3 99.53 5.35 1189 795017626 XP_011858919.1 264 1.9e-20 PREDICTED: uncharacterized protein LOC105556435, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5322 BP_3 53.00 2.14 1485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53220 BP_3 56.00 1.68 1901 478252327 ENN72753.1 442 6.9e-41 hypothetical protein YQE_10558, partial [Dendroctonus ponderosae] -- -- -- -- -- K00861 RFK, FMN1 riboflavin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00861 Q8CFV9 418 1.7e-39 Riboflavin kinase OS=Mus musculus GN=Rfk PE=1 SV=2 PF01687 Riboflavin kinase GO:0009231 riboflavin biosynthetic process GO:0008531 riboflavin kinase activity -- -- KOG3110 Riboflavin kinase Cluster-8309.53221 BP_3 277.86 6.29 2421 91092636 XP_968782.1 1194 5.5e-128 PREDICTED: neurogenic protein big brain [Tribolium castaneum]>gi|270014847|gb|EFA11295.1| hypothetical protein TcasGA2_TC010832 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 P23645 1046 3.3e-112 Neurogenic protein big brain OS=Drosophila melanogaster GN=bib PE=1 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.53222 BP_3 45.61 1.02 2454 478249755 ENN70263.1 495 6.4e-47 hypothetical protein YQE_13046, partial [Dendroctonus ponderosae] -- -- -- -- -- K06695 PSMC3IP 26S proteasome regulatory subunit, ATPase 3, interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K06695 Q63ZL2 310 7.4e-27 Homologous-pairing protein 2 homolog OS=Xenopus laevis GN=psmc3ip PE=2 SV=1 PF10186//PF08702//PF02601//PF03965//PF03647//PF06156 Vacuolar sorting 38 and autophagy-related subunit 14//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Penicillinase repressor//Transmembrane proteins 14C//Protein of unknown function (DUF972) GO:0051258//GO:0007165//GO:0010508//GO:0006308//GO:0030168//GO:0006260//GO:0045892 protein polymerization//signal transduction//positive regulation of autophagy//DNA catabolic process//platelet activation//DNA replication//negative regulation of transcription, DNA-templated GO:0008855//GO:0003677//GO:0005102//GO:0030674 exodeoxyribonuclease VII activity//DNA binding//receptor binding//protein binding, bridging GO:0005577//GO:0016020//GO:0009318 fibrinogen complex//membrane//exodeoxyribonuclease VII complex KOG4603 TBP-1 interacting protein Cluster-8309.53223 BP_3 10.00 1.04 756 24643074 NP_573311.1 149 2.6e-07 CG15040 [Drosophila melanogaster]>gi|7293488|gb|AAF48863.1| CG15040 [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- Q55FT4 131 1.3e-06 Probable serine/threonine-protein kinase tsuA OS=Dictyostelium discoideum GN=tsuA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53225 BP_3 523.00 5.75 4676 270014284 EFA10732.1 3928 0.0e+00 teashirt-like protein [Tribolium castaneum] 86515361 NM_001039415.1 731 0 Tribolium castaneum teashirt-like protein (Tiotsh), mRNA >gnl|BL_ORD_ID|994588 Tribolium castaneum clone pctsh10 teashirt-like protein mRNA, complete cds -- -- -- -- Q9U3V5 1208 1.1e-130 Protein tiptop OS=Drosophila melanogaster GN=tio PE=2 SV=2 PF01277//PF11045//PF00096//PF13912//PF06467 Oleosin//Putative inner membrane protein of Enterobacteriaceae//Zinc finger, C2H2 type//C2H2-type zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane -- -- Cluster-8309.53228 BP_3 93.79 0.92 5186 642912101 XP_008200805.1 181 3.5e-10 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53230 BP_3 1.00 1.72 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53231 BP_3 108.13 0.43 12503 270013018 EFA09466.1 7223 0.0e+00 hypothetical protein TcasGA2_TC010960 [Tribolium castaneum] 667677299 AE014296.5 67 3.24766e-23 Drosophila melanogaster chromosome 3L K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8WXX0 4882 0.0e+00 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 PF05418//PF00580//PF01637//PF04851//PF00910//PF02601//PF01695//PF07728//PF00158//PF00437//PF00004//PF02224//PF03028//PF07724 Apovitellenin I (Apo-VLDL-II)//UvrD/REP helicase N-terminal domain//Archaeal ATPase//Type III restriction enzyme, res subunit//RNA helicase//Exonuclease VII, large subunit//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//Dynein heavy chain and region D6 of dynein motor//AAA domain (Cdc48 subfamily) GO:0007017//GO:0006355//GO:0006810//GO:0006139//GO:0007018//GO:0006308//GO:0006206//GO:0006629 microtubule-based process//regulation of transcription, DNA-templated//transport//nucleobase-containing compound metabolic process//microtubule-based movement//DNA catabolic process//pyrimidine nucleobase metabolic process//lipid metabolic process GO:0004127//GO:0016887//GO:0008134//GO:0016787//GO:0005524//GO:0003724//GO:0003777//GO:0004857//GO:0008855//GO:0003677//GO:0003723 cytidylate kinase activity//ATPase activity//transcription factor binding//hydrolase activity//ATP binding//RNA helicase activity//microtubule motor activity//enzyme inhibitor activity//exodeoxyribonuclease VII activity//DNA binding//RNA binding GO:0042627//GO:0009318//GO:0005667//GO:0005874//GO:0030286 chylomicron//exodeoxyribonuclease VII complex//transcription factor complex//microtubule//dynein complex -- -- Cluster-8309.53234 BP_3 181.48 1.80 5147 617299376 XP_007570232.1 969 1.5e-101 PREDICTED: zinc finger protein 236 [Poecilia formosa] -- -- -- -- -- -- -- -- -- P10076 663 1.8e-67 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.53235 BP_3 217.39 2.17 5129 617299376 XP_007570232.1 969 1.4e-101 PREDICTED: zinc finger protein 236 [Poecilia formosa] -- -- -- -- -- -- -- -- -- P10076 663 1.8e-67 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.53236 BP_3 122.12 1.29 4840 617299376 XP_007570232.1 686 8.9e-69 PREDICTED: zinc finger protein 236 [Poecilia formosa] -- -- -- -- -- -- -- -- -- Q9UL36 585 1.9e-58 Zinc finger protein 236 OS=Homo sapiens GN=ZNF236 PE=2 SV=2 PF00096//PF13465//PF01155//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//BED zinc finger//C2H2-type zinc finger GO:0006464 cellular protein modification process GO:0046872//GO:0016151//GO:0003677 metal ion binding//nickel cation binding//DNA binding -- -- -- -- Cluster-8309.53237 BP_3 3.00 0.36 695 270012045 EFA08493.1 341 1.3e-29 hypothetical protein TcasGA2_TC006145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53238 BP_3 58.89 2.30 1525 91093505 XP_969151.1 1925 6.0e-213 PREDICTED: NADP-dependent malic enzyme [Tribolium castaneum]>gi|270002678|gb|EEZ99125.1| hypothetical protein TcasGA2_TC005232 [Tribolium castaneum] 194765020 XM_001964590.1 291 1.17055e-148 Drosophila ananassae GF23280 (Dana\GF23280), mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1320 3.5e-144 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF00390//PF03949 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain GO:0055114//GO:0006108//GO:0006099//GO:0015976//GO:0006090 oxidation-reduction process//malate metabolic process//tricarboxylic acid cycle//carbon utilization//pyruvate metabolic process GO:0046872//GO:0004471//GO:0051287 metal ion binding//malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.53239 BP_3 308.48 8.73 1994 642914834 XP_008194983.1 1294 1.2e-139 PREDICTED: inhibitor of growth protein 3 isoform X1 [Tribolium castaneum] 795091176 XM_012024084.1 52 1.11328e-15 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q9NXR8 680 7.5e-70 Inhibitor of growth protein 3 OS=Homo sapiens GN=ING3 PE=1 SV=2 PF00160//PF10280//PF12090//PF03153 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Mediator complex protein//Spt20 family//Transcription factor IIA, alpha/beta subunit GO:0006457//GO:0006357//GO:0006367//GO:0000413 protein folding//regulation of transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//protein peptidyl-prolyl isomerization GO:0001104//GO:0003755//GO:0003712 RNA polymerase II transcription cofactor activity//peptidyl-prolyl cis-trans isomerase activity//transcription cofactor activity GO:0016592//GO:0005667//GO:0000124//GO:0005672 mediator complex//transcription factor complex//SAGA complex//transcription factor TFIIA complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.53241 BP_3 685.39 22.73 1745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53247 BP_3 99.72 1.08 4753 270010030 EFA06478.1 760 2.3e-77 hypothetical protein TcasGA2_TC009372 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53251 BP_3 262.01 2.15 6162 642915658 XP_008190700.1 5297 0.0e+00 PREDICTED: nephrin isoform X1 [Tribolium castaneum]>gi|642915662|ref|XP_008190702.1| PREDICTED: nephrin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZS7 1262 7.6e-137 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF05434//PF00041//PF13895 TMEM9//Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules Cluster-8309.53252 BP_3 6.00 1.54 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53254 BP_3 133.68 4.24 1810 642911837 XP_008200767.1 194 3.8e-12 PREDICTED: endophilin-A isoform X4 [Tribolium castaneum] -- -- -- -- -- K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I1A6 171 7.2e-11 Endophilin-A OS=Drosophila willistoni GN=endoA PE=3 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation Cluster-8309.53259 BP_3 325.13 4.94 3467 546680054 ERL90409.1 2899 0.0e+00 hypothetical protein D910_07758, partial [Dendroctonus ponderosae] -- -- -- -- -- K13146 INTS9 integrator complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13146 Q8K114 1741 1.2e-192 Integrator complex subunit 9 OS=Mus musculus GN=Ints9 PE=2 SV=1 PF00076//PF01896//PF05625 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Eukaryotic and archaeal DNA primase small subunit//PAXNEB protein GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896//GO:0003676 DNA primase activity//nucleic acid binding GO:0005657//GO:0005730//GO:0033588 replication fork//nucleolus//Elongator holoenzyme complex KOG1138 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.53260 BP_3 11.68 0.58 1268 34099638 AAQ57129.1 871 8.3e-91 endonuclease and reverse transcriptase-like protein [Bombyx mori] 347439535 JN415099.1 335 3.36279e-173 Scylla paramamosain clone QX04 microsatellite sequence -- -- -- -- Q95SX7 344 4.4e-31 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF09004 Domain of unknown function (DUF1891) GO:0055114 oxidation-reduction process GO:0008168//GO:0016706 methyltransferase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.53261 BP_3 225.43 3.12 3774 642918805 XP_008191593.1 3414 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 2080 6.5e-232 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0208 Cation transport ATPase Cluster-8309.53263 BP_3 75.09 1.13 3507 642918805 XP_008191593.1 2275 3.6e-253 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 1426 4.1e-156 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0208 Cation transport ATPase Cluster-8309.5327 BP_3 54.63 1.90 1675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53271 BP_3 52.79 0.66 4129 861615769 KMQ86193.1 1625 1.0e-177 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P10978 1358 3.7e-148 Retrovirus-related Pol polyprotein from transposon TNT 1-94 OS=Nicotiana tabacum PE=2 SV=1 PF00665//PF00098//PF13683//PF02932 Integrase core domain//Zinc knuckle//Integrase core domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0015074 ion transport//DNA integration GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.53273 BP_3 53.77 0.66 4212 270008864 EFA05312.1 1399 1.6e-151 hypothetical protein TcasGA2_TC015470 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04146 688 1.9e-70 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF13683//PF00098//PF00665//PF02932 Integrase core domain//Zinc knuckle//Integrase core domain//Neurotransmitter-gated ion-channel transmembrane region GO:0015074//GO:0006811 DNA integration//ion transport GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.53274 BP_3 22.00 0.31 3747 226510844 ACO59955.1 604 2.2e-59 beta-amyloid precursor-like protein [Neohelice granulata] -- -- -- -- -- K04520 APP amyloid beta A4 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04520 P14599 270 4.9e-22 Beta-amyloid-like protein OS=Drosophila melanogaster GN=Appl PE=1 SV=2 PF04995 Heme exporter protein D (CcmD) GO:0015886//GO:0017004 heme transport//cytochrome complex assembly -- -- GO:0016021 integral component of membrane KOG3540 Beta amyloid precursor protein Cluster-8309.53281 BP_3 36.81 0.49 3942 270016078 EFA12526.1 1399 1.5e-151 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 710 4.9e-73 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.53283 BP_3 13.36 0.44 1761 270014029 EFA10477.1 227 5.5e-16 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 571562937 XM_006570457.1 56 5.8617e-18 PREDICTED: Apis mellifera uncharacterized LOC551624 (LOC551624), transcript variant X2, mRNA -- -- -- -- O94842 141 2.1e-07 TOX high mobility group box family member 4 OS=Homo sapiens GN=TOX4 PE=1 SV=1 PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.53285 BP_3 5.54 0.43 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53289 BP_3 389.54 6.44 3209 270003759 EFA00207.1 1160 6.4e-124 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 3.82004e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.0e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.53291 BP_3 150.55 1.73 4492 642919497 XP_008191896.1 2896 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53292 BP_3 294.13 2.78 5400 642919497 XP_008191896.1 2940 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53293 BP_3 12.00 1.49 679 91088247 XP_974080.1 211 1.5e-14 PREDICTED: POC1 centriolar protein homolog B [Tribolium castaneum]>gi|270011818|gb|EFA08266.1| hypothetical protein TcasGA2_TC005896 [Tribolium castaneum] -- -- -- -- -- K16482 POC1 centriolar protein POC1 http://www.genome.jp/dbget-bin/www_bget?ko:K16482 Q28I85 198 2.0e-14 POC1 centriolar protein homolog A OS=Xenopus tropicalis GN=poc1a PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53296 BP_3 10.00 0.62 1066 674304006 AIL23534.1 424 4.7e-39 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 286 2.0e-24 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53297 BP_3 80.68 0.57 7155 642912301 XP_968800.3 1228 1.9e-131 PREDICTED: protein couch potato isoform X2 [Tribolium castaneum] 642912300 XM_963707.3 407 0 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X2, mRNA -- -- -- -- Q01617 796 9.6e-83 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00168//PF00076 C2 domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.53298 BP_3 153.54 5.62 1609 642912303 XP_008200641.1 626 2.7e-62 PREDICTED: protein couch potato isoform X3 [Tribolium castaneum] 642912302 XM_008202419.1 206 2.20519e-101 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X3, mRNA -- -- -- -- Q01617 332 1.4e-29 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00076//PF17051 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Cytochrome C oxidase assembly factor 2 GO:0033617 mitochondrial respiratory chain complex IV assembly GO:0003676 nucleic acid binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.53299 BP_3 11.00 0.79 966 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.533 BP_3 15.47 0.32 2615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53301 BP_3 50.16 1.78 1653 817088843 XP_012267256.1 438 1.7e-40 PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae]>gi|817088845|ref|XP_012267257.1| PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae] -- -- -- -- -- K03004 RPA43 DNA-directed RNA polymerase I subunit RPA43 http://www.genome.jp/dbget-bin/www_bget?ko:K03004 Q3B726 275 5.7e-23 DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens GN=TWISTNB PE=1 SV=1 PF03876 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG4134 DNA-dependent RNA polymerase I Cluster-8309.53304 BP_3 32.68 0.47 3625 602166190 AHN85842.1 1751 2.1e-192 octopamine beta receptor 2 [Nicrophorus vespilloides] -- -- -- -- -- K04160 HTR4 5-hydroxytryptamine receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04160 Q4LBB9 1334 2.0e-145 Octopamine receptor beta-2R OS=Drosophila melanogaster GN=Octbeta2R PE=2 SV=2 PF00001//PF01769//PF01717 7 transmembrane receptor (rhodopsin family)//Divalent cation transporter//Cobalamin-independent synthase, Catalytic domain GO:0009086//GO:0007186//GO:0006812 methionine biosynthetic process//G-protein coupled receptor signaling pathway//cation transport GO:0004930//GO:0008324//GO:0008270//GO:0003871 G-protein coupled receptor activity//cation transmembrane transporter activity//zinc ion binding//5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.53305 BP_3 171.61 2.45 3667 642918209 XP_008191412.1 1177 7.9e-126 PREDICTED: methyltransferase-like protein 9 isoform X1 [Tribolium castaneum]>gi|270004533|gb|EFA00981.1| hypothetical protein TcasGA2_TC003894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EPL4 639 7.9e-65 Methyltransferase-like protein 9 OS=Mus musculus GN=Mettl9 PE=2 SV=1 PF08241//PF04218//PF01234//PF05958 Methyltransferase domain//CENP-B N-terminal DNA-binding domain//NNMT/PNMT/TEMT family//tRNA (Uracil-5-)-methyltransferase GO:0006396//GO:0008152//GO:0009451 RNA processing//metabolic process//RNA modification GO:0008173//GO:0008168//GO:0003677 RNA methyltransferase activity//methyltransferase activity//DNA binding -- -- KOG3987 Uncharacterized conserved protein DREV/CGI-81 Cluster-8309.53306 BP_3 6.61 0.33 1250 642925968 XP_008194714.1 213 1.6e-14 PREDICTED: uncharacterized protein LOC655532 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53308 BP_3 10.00 0.66 1018 662215753 XP_008481775.1 594 8.8e-59 PREDICTED: uncharacterized protein LOC103518486 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P04323 455 4.7e-44 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.53311 BP_3 63.92 0.53 6108 270004778 EFA01226.1 1478 1.6e-160 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1060 2.0e-113 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF16867//PF00665 Integrase core domain//Dimethlysulfonioproprionate lyase//Integrase core domain GO:0015074 DNA integration GO:0047869 dimethylpropiothetin dethiomethylase activity -- -- -- -- Cluster-8309.53314 BP_3 42.56 0.49 4454 -- -- -- -- -- 462391137 APGK01018557.1 46 5.43302e-12 Dendroctonus ponderosae Seq01018567, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF03523 Macrophage scavenger receptor GO:0007165//GO:0006898 signal transduction//receptor-mediated endocytosis GO:0005044 scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.53322 BP_3 146.89 5.25 1641 546677957 ERL88690.1 242 9.3e-18 hypothetical protein D910_06073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53323 BP_3 44.00 1.26 1969 270009808 EFA06256.1 670 2.6e-67 hypothetical protein TcasGA2_TC009115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04146 142 1.8e-07 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF00098 Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.53324 BP_3 1175.67 22.71 2787 546674612 ERL85961.1 989 3.8e-104 hypothetical protein D910_03376 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SPP0 594 9.9e-60 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 PF08675 RNA binding domain GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0046872//GO:0004535//GO:0003723 metal ion binding//poly(A)-specific ribonuclease activity//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.53325 BP_3 9.00 0.79 838 642928984 XP_008195645.1 904 8.1e-95 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09849 615 1.1e-62 Lactase-phlorizin hydrolase OS=Oryctolagus cuniculus GN=LCT PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0016798//GO:0004553 hydrolase activity, acting on glycosyl bonds//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.53327 BP_3 10.00 0.43 1413 748995278 AJE75661.1 853 1.1e-88 putative glycosyl hydrolase [Chrysomela lapponica] 636630775 KJ576835.1 42 2.83654e-10 Periplaneta americana clone PA_BetaGlu_1701 beta-glucosidase mRNA, complete cds K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 656 3.2e-67 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00150//PF00232 Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.53329 BP_3 249.78 2.69 4763 478251175 ENN71651.1 1844 4.6e-203 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2N4 902 3.3e-95 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.53332 BP_3 379.44 9.90 2139 642926395 XP_970524.2 955 2.5e-100 PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926397|ref|XP_008191945.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926399|ref|XP_008191946.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum] -- -- -- -- -- K07899 RAB9A, RAB9 Ras-related protein Rab-9A http://www.genome.jp/dbget-bin/www_bget?ko:K07899 Q99P75 613 4.7e-62 Ras-related protein Rab-9A OS=Rattus norvegicus GN=Rab9a PE=1 SV=2 PF08477//PF00735//PF01926//PF00025//PF03193//PF01637//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//Septin//50S ribosome-binding GTPase//ADP-ribosylation factor family//Protein of unknown function, DUF258//Archaeal ATPase//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- KOG0394 Ras-related GTPase Cluster-8309.53334 BP_3 123.06 1.89 3437 546687691 ERL96264.1 1510 1.8e-164 hypothetical protein D910_01676 [Dendroctonus ponderosae] -- -- -- -- -- K02603 ORC1 origin recognition complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02603 O16810 1161 2.2e-125 Origin recognition complex subunit 1 OS=Drosophila melanogaster GN=Orc1 PE=1 SV=2 PF05790//PF00004 Immunoglobulin C2-set domain//ATPase family associated with various cellular activities (AAA) GO:0007155 cell adhesion GO:0005524 ATP binding GO:0016021 integral component of membrane KOG1514 Origin recognition complex, subunit 1, and related proteins Cluster-8309.53336 BP_3 196.52 1.31 7531 167234451 NP_001107840.1 1588 3.6e-173 Dicer-2 [Tribolium castaneum]>gi|642913971|ref|XP_008201496.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|642913973|ref|XP_008201497.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|270002830|gb|EEZ99277.1| hypothetical protein TcasGA2_TC001108 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34529 664 2.0e-67 Endoribonuclease dcr-1 OS=Caenorhabditis elegans GN=dcr-1 PE=1 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0016072//GO:0051252//GO:0034470 rRNA metabolic process//regulation of RNA metabolic process//ncRNA processing GO:0003676//GO:0016891//GO:0043167//GO:0003677//GO:0016787//GO:0005524//GO:0004386//GO:0003723 nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters//ion binding//DNA binding//hydrolase activity//ATP binding//helicase activity//RNA binding -- -- KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.53337 BP_3 21.10 0.31 3625 642913461 XP_008201022.1 1542 3.7e-168 PREDICTED: uncharacterized protein LOC663795 [Tribolium castaneum] 642913460 XM_008202800.1 44 5.7093e-11 PREDICTED: Tribolium castaneum uncharacterized LOC663795 (LOC663795), mRNA -- -- -- -- -- -- -- -- PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.53338 BP_3 935.60 2.67 17178 642935122 XP_008197897.1 19614 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 1002 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q61555 1378 7.5e-150 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF00008//PF06553//PF07645 EGF-like domain//BNIP3//Calcium-binding EGF domain GO:0043065 positive regulation of apoptotic process GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.53339 BP_3 175.06 1.39 6345 642935122 XP_008197897.1 9537 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 1051 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 678 4.1e-69 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53340 BP_3 213.88 0.85 12406 270013710 EFA10158.1 5372 0.0e+00 hypothetical protein TcasGA2_TC012347 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 5.0e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF00960//PF05510//PF00536//PF06553//PF03400//PF13606//PF00023 Neocarzinostatin family//Sarcoglycan alpha/epsilon//SAM domain (Sterile alpha motif)//BNIP3//IS1 transposase//Ankyrin repeat//Ankyrin repeat GO:0006952//GO:0006313//GO:0043065 defense response//transposition, DNA-mediated//positive regulation of apoptotic process GO:0005515//GO:0003677//GO:0004803 protein binding//DNA binding//transposase activity GO:0016021//GO:0016012//GO:0005740 integral component of membrane//sarcoglycan complex//mitochondrial envelope -- -- Cluster-8309.53341 BP_3 39.82 0.59 3541 642918701 XP_008191545.1 1571 1.6e-171 PREDICTED: protein sprint isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 643 2.6e-65 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.53344 BP_3 2228.00 10.19 10830 642920841 XP_008192580.1 12538 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein dachsous [Tribolium castaneum] 170031842 XM_001843741.1 41 7.98557e-09 Culex quinquefasciatus cadherin, mRNA K16507 DCHS1_2, PCDH16_23 protocadherin-16/23 http://www.genome.jp/dbget-bin/www_bget?ko:K16507 Q24292 6882 0.0e+00 Protein dachsous OS=Drosophila melanogaster GN=ds PE=1 SV=3 PF01247//PF01049//PF00028 Ribosomal protein L35Ae//Cadherin cytoplasmic region//Cadherin domain GO:0042254//GO:0006412//GO:0007156 ribosome biogenesis//translation//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0003735 calcium ion binding//structural constituent of ribosome GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.53346 BP_3 227.89 5.07 2460 642921104 XP_008192691.1 1190 1.6e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.6e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF15678//PF09726//PF05279//PF02535//PF04882 Centriole duplication and mitotic chromosome congression//Transmembrane protein//Aspartyl beta-hydroxylase N-terminal region//ZIP Zinc transporter//Peroxin-3 GO:0055085//GO:0007031//GO:0030001//GO:0090307 transmembrane transport//peroxisome organization//metal ion transport//mitotic spindle assembly GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005779//GO:0016021 membrane//integral component of peroxisomal membrane//integral component of membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.53347 BP_3 4.00 0.41 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53349 BP_3 133.22 3.60 2076 189234531 XP_967948.2 889 1.1e-92 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 693 2.4e-71 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006811//GO:0006810//GO:0055085 ion transport//transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.53350 BP_3 917.45 8.22 5674 642920242 XP_008192264.1 5773 0.0e+00 PREDICTED: uncharacterized protein CG43867 isoform X2 [Tribolium castaneum] 194768448 XM_001966288.1 67 1.46928e-23 Drosophila ananassae GF22056 (Dana\GF22056), mRNA -- -- -- -- Q9W5D0 2338 1.2e-261 Uncharacterized protein CG43867 OS=Drosophila melanogaster GN=CG43867 PE=1 SV=4 PF05864//PF00784 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//MyTH4 domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005856//GO:0005730 cytoskeleton//nucleolus KOG0248 Cytoplasmic protein Max-1, contains PH, MyTH4 and FERM domains Cluster-8309.53351 BP_3 966.99 3.63 13147 642930187 XP_008196292.1 4575 0.0e+00 PREDICTED: spatacsin [Tribolium castaneum]>gi|270009457|gb|EFA05905.1| hypothetical protein TcasGA2_TC008718 [Tribolium castaneum] 195121589 XM_002005267.1 94 3.34371e-38 Drosophila mojavensis GI20407 (Dmoj\GI20407), mRNA K07832 RIT1 Ras-like without CAAX 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07832 Q3UHA3 742 3.2e-76 Spatacsin OS=Mus musculus GN=Spg11 PE=2 SV=3 PF00962//PF03193//PF02459//PF00071//PF01979//PF08477//PF08533//PF00025 Adenosine/AMP deaminase//Protein of unknown function, DUF258//Adenoviral DNA terminal protein//Ras family//Amidohydrolase family//Ras of Complex, Roc, domain of DAPkinase//Beta-galactosidase C-terminal domain//ADP-ribosylation factor family GO:0006027//GO:0006012//GO:0007264//GO:0046486//GO:0006687//GO:0006260 glycosaminoglycan catabolic process//galactose metabolic process//small GTPase mediated signal transduction//glycerolipid metabolic process//glycosphingolipid metabolic process//DNA replication GO:0019239//GO:0003924//GO:0016787//GO:0003677//GO:0004565//GO:0005525 deaminase activity//GTPase activity//hydrolase activity//DNA binding//beta-galactosidase activity//GTP binding GO:0009341 beta-galactosidase complex KOG0395 Ras-related GTPase Cluster-8309.53354 BP_3 146.16 2.87 2750 642924514 XP_008194327.1 841 5.4e-87 PREDICTED: nuclear fragile X mental retardation-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXX8 333 1.8e-29 Nuclear fragile X mental retardation-interacting protein 1 OS=Mus musculus GN=Nufip1 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.53356 BP_3 15.95 8.06 385 549438545 AGX25161.1 160 6.9e-09 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53359 BP_3 27.49 0.52 2828 642923711 XP_974199.2 2818 0.0e+00 PREDICTED: protein smg8 [Tribolium castaneum] -- -- -- -- -- K18734 SMG8 protein SMG8 http://www.genome.jp/dbget-bin/www_bget?ko:K18734 B0W730 645 1.2e-65 Protein SMG8 OS=Culex quinquefasciatus GN=CPIJ003128 PE=3 SV=1 PF08653//PF10220 DASH complex subunit Dam1//Uncharacterized conserved protein (DUF2146) GO:0000184//GO:0008608 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG3692 Uncharacterized conserved protein Cluster-8309.53361 BP_3 110.46 1.51 3823 189237458 XP_967667.2 522 7.3e-50 PREDICTED: solute carrier family 35 member E2-like [Tribolium castaneum] -- -- -- -- -- K15284 SLC35E2 solute carrier family 35, member E2 http://www.genome.jp/dbget-bin/www_bget?ko:K15284 Q8C811 281 2.7e-23 Solute carrier family 35 member E2 OS=Mus musculus GN=Slc35e2 PE=2 SV=1 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.53362 BP_3 420.15 4.29 5013 478251160 ENN71636.1 1384 1.1e-149 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04931//PF01080//PF02724//PF04843 DNA polymerase phi//Presenilin//CDC45-like protein//Herpesvirus tegument protein, N-terminal conserved region GO:0006508//GO:0006260//GO:0006270//GO:0006351 proteolysis//DNA replication//DNA replication initiation//transcription, DNA-templated GO:0008233//GO:0003887//GO:0004190//GO:0003677 peptidase activity//DNA-directed DNA polymerase activity//aspartic-type endopeptidase activity//DNA binding GO:0042575//GO:0016021 DNA polymerase complex//integral component of membrane -- -- Cluster-8309.53367 BP_3 289.14 2.77 5318 91078468 XP_967964.1 2089 2.0e-231 PREDICTED: integral membrane protein GPR180 isoform X1 [Tribolium castaneum]>gi|270003859|gb|EFA00307.1| hypothetical protein TcasGA2_TC003142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q976I0 277 1.1e-22 Peptidyl-tRNA hydrolase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=pth PE=3 SV=1 PF10192//PF01981//PF02891//PF05051 Rhodopsin-like GPCR transmembrane domain//Peptidyl-tRNA hydrolase PTH2//MIZ/SP-RING zinc finger//Cytochrome C oxidase copper chaperone (COX17) GO:0019236//GO:0007186//GO:0006825 response to pheromone//G-protein coupled receptor signaling pathway//copper ion transport GO:0008270//GO:0004045//GO:0005507//GO:0016531 zinc ion binding//aminoacyl-tRNA hydrolase activity//copper ion binding//copper chaperone activity GO:0005758 mitochondrial intermembrane space KOG3282 Uncharacterized conserved protein Cluster-8309.5337 BP_3 11.15 0.32 1987 499037689 XP_004569491.1 435 4.7e-40 PREDICTED: zinc finger protein 883-like [Maylandia zebra] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17141 424 3.6e-40 Zinc finger protein 37 OS=Mus musculus GN=Zfp37 PE=2 SV=4 PF13912//PF16622//PF13465//PF00096 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.53370 BP_3 1284.92 21.27 3204 91084489 XP_971806.1 629 2.4e-62 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103 CD20-like family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.53373 BP_3 8.00 0.36 1358 642929789 XP_008195977.1 340 3.3e-29 PREDICTED: oxysterol-binding protein-related protein 9 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A8Z1 175 1.8e-11 Oxysterol-binding protein-related protein 9 OS=Mus musculus GN=Osbpl9 PE=1 SV=1 PF03510 2C endopeptidase (C24) cysteine protease family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.53381 BP_3 13.58 0.50 1594 642935612 XP_008198081.1 1107 4.5e-118 PREDICTED: probable elongator complex protein 2 [Tribolium castaneum]>gi|270013922|gb|EFA10370.1| hypothetical protein TcasGA2_TC012601 [Tribolium castaneum] -- -- -- -- -- K11374 ELP2 elongator complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11374 Q5EBD9 742 3.9e-77 Elongator complex protein 2 OS=Xenopus tropicalis GN=elp2 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily Cluster-8309.53383 BP_3 381.74 7.94 2609 642935612 XP_008198081.1 2423 1.8e-270 PREDICTED: probable elongator complex protein 2 [Tribolium castaneum]>gi|270013922|gb|EFA10370.1| hypothetical protein TcasGA2_TC012601 [Tribolium castaneum] 820980913 XM_012506317.1 42 5.29844e-10 PREDICTED: Nomascus leucogenys elongator acetyltransferase complex subunit 2 (ELP2), mRNA K11374 ELP2 elongator complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11374 Q7K4B3 1803 5.9e-200 Probable elongator complex protein 2 OS=Drosophila melanogaster GN=Elp2 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily Cluster-8309.53386 BP_3 533.82 9.01 3146 642932460 XP_008197124.1 2253 1.1e-250 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase epsilon [Tribolium castaneum] -- -- -- -- -- K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q9R1C6 1022 2.6e-109 Diacylglycerol kinase epsilon OS=Mus musculus GN=Dgke PE=2 SV=1 PF00781//PF00609//PF00130 Diacylglycerol kinase catalytic domain//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007205//GO:0009395//GO:0046486//GO:0035556 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process//intracellular signal transduction GO:0016301//GO:0004143 kinase activity//diacylglycerol kinase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.53387 BP_3 112.67 1.04 5522 270006429 EFA02877.1 3072 0.0e+00 hypothetical protein TcasGA2_TC008029 [Tribolium castaneum] -- -- -- -- -- K17495 CSMD CUB and sushi domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K17495 P0C6B8 1411 3.6e-154 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus GN=Svep1 PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53392 BP_3 275.11 5.39 2752 642925556 XP_971635.2 668 6.2e-67 PREDICTED: estrogen sulfotransferase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52845 368 1.6e-33 Estrogen sulfotransferase, isoform 2 OS=Rattus norvegicus GN=Ste2 PE=2 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.53399 BP_3 741.11 11.46 3409 642914114 XP_008201549.1 3054 0.0e+00 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X2 [Tribolium castaneum] 642914119 XM_008203330.1 557 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q68DX3 206 1.2e-14 FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=3 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.534 BP_3 30.91 0.65 2584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53401 BP_3 31.53 0.34 4752 642914114 XP_008201549.1 2831 0.0e+00 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X2 [Tribolium castaneum] 642914119 XM_008203330.1 483 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q68DX3 206 1.6e-14 FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53406 BP_3 48.44 0.91 2864 642930216 XP_970192.2 1626 5.3e-178 PREDICTED: protein UBASH3A homolog isoform X1 [Tribolium castaneum] 642930215 XM_965099.2 283 6.21901e-144 PREDICTED: Tribolium castaneum protein UBASH3A homolog (LOC658737), transcript variant X1, mRNA K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 1265 1.6e-137 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.53407 BP_3 3.00 0.38 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5341 BP_3 14.81 0.37 2219 642937652 XP_966876.3 600 3.8e-59 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62836 366 2.2e-33 Zinc finger X-chromosomal protein OS=Bos taurus GN=ZFX PE=2 SV=2 PF06784//PF13465//PF00096 Uncharacterised protein family (UPF0240)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0032981 mitochondrial respiratory chain complex I assembly GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.53411 BP_3 6.29 0.54 856 91082701 XP_971906.1 419 1.4e-38 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] 462332875 APGK01039175.1 89 1.26297e-36 Dendroctonus ponderosae Seq01039185, whole genome shotgun sequence -- -- -- -- O15126 190 2.1e-13 Secretory carrier-associated membrane protein 1 OS=Homo sapiens GN=SCAMP1 PE=1 SV=2 PF04144//PF00049 SCAMP family//Insulin/IGF/Relaxin family GO:0015031//GO:0007165 protein transport//signal transduction GO:0005179 hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3088 Secretory carrier membrane protein Cluster-8309.53413 BP_3 31.21 0.66 2559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53414 BP_3 181.00 4.72 2141 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53415 BP_3 303.00 7.68 2194 668455665 KFB43924.1 230 3.0e-16 hypothetical protein ZHAS_00011749 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- P82120 176 2.3e-11 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.53423 BP_3 44.39 0.72 3254 642924384 XP_008194273.1 3213 0.0e+00 PREDICTED: WD repeat-containing protein 59 [Tribolium castaneum]>gi|270007891|gb|EFA04339.1| hypothetical protein TcasGA2_TC014633 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKK2 1540 2.3e-169 WD repeat-containing protein 59 homolog OS=Drosophila melanogaster GN=CG4705 PE=1 SV=3 PF05773//PF00400 RWD domain//WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0309 Conserved WD40 repeat-containing protein Cluster-8309.53425 BP_3 1.00 35.97 213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53431 BP_3 67.16 1.25 2880 642930150 XP_008196273.1 1751 1.7e-192 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X7 [Tribolium castaneum] 189164165 EU545256.1 262 2.95126e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1238 2.1e-134 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.53432 BP_3 382.66 9.07 2325 546671091 ERL83562.1 337 1.3e-28 hypothetical protein D910_00648 [Dendroctonus ponderosae]>gi|546671774|gb|ERL83943.1| hypothetical protein D910_01236 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53433 BP_3 408.80 20.80 1239 91086847 XP_974260.1 1027 6.6e-109 PREDICTED: BSD domain-containing protein 1-B [Tribolium castaneum]>gi|270010460|gb|EFA06908.1| hypothetical protein TcasGA2_TC009857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BJ78 321 2.0e-28 BSD domain-containing protein 1 OS=Xenopus tropicalis GN=bsdc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2690 Uncharacterized conserved protein, contains BSD domain Cluster-8309.53434 BP_3 6.02 0.40 1013 91089133 XP_972853.1 633 2.6e-63 PREDICTED: THO complex subunit 5 homolog [Tribolium castaneum]>gi|270011509|gb|EFA07957.1| hypothetical protein TcasGA2_TC005538 [Tribolium castaneum] -- -- -- -- -- K13174 THOC5 THO complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13174 Q7ZXA8 375 8.9e-35 THO complex subunit 5 homolog B OS=Xenopus laevis GN=thoc5-b PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2216 Conserved coiled/coiled coil protein Cluster-8309.53436 BP_3 13.86 0.35 2180 642926177 XP_008194817.1 247 3.2e-18 PREDICTED: protein LSM12 homolog A-like [Tribolium castaneum]>gi|270008537|gb|EFA04985.1| hypothetical protein TcasGA2_TC015064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53437 BP_3 19.22 0.50 2160 642926177 XP_008194817.1 247 3.2e-18 PREDICTED: protein LSM12 homolog A-like [Tribolium castaneum]>gi|270008537|gb|EFA04985.1| hypothetical protein TcasGA2_TC015064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53438 BP_3 10.01 0.36 1621 642930742 XP_008196074.1 517 1.2e-49 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- K04919 KCNK9 potassium channel subfamily K member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04919 O35111 189 5.3e-13 Potassium channel subfamily K member 3 OS=Mus musculus GN=Kcnk3 PE=2 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.5344 BP_3 13.23 0.31 2374 270007714 EFA04162.1 284 1.8e-22 hypothetical protein TcasGA2_TC014408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53443 BP_3 9.59 0.32 1731 91094587 XP_970350.1 710 5.3e-72 PREDICTED: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [Tribolium castaneum] 642939259 XM_965257.2 152 2.47915e-71 PREDICTED: Tribolium castaneum high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (LOC658906), mRNA K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53445 BP_3 158.16 7.92 1254 861599125 KMQ83546.1 659 3.1e-66 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53449 BP_3 230.95 2.03 5769 478250909 ENN71394.1 603 4.5e-59 hypothetical protein YQE_11898, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9QX47 328 1.4e-28 Protein SON OS=Mus musculus GN=Son PE=1 SV=2 PF05493//PF01585 ATP synthase subunit H//G-patch domain GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0003676//GO:0015078 nucleic acid binding//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.53453 BP_3 53.70 0.62 4461 478251484 ENN71947.1 839 1.5e-86 hypothetical protein YQE_11381, partial [Dendroctonus ponderosae] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 454 2.7e-43 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF01750//PF00474 Hydrogenase maturation protease//Sodium:solute symporter family GO:0055085//GO:0006810 transmembrane transport//transport GO:0008047//GO:0005215//GO:0008233 enzyme activator activity//transporter activity//peptidase activity GO:0016020 membrane -- -- Cluster-8309.53455 BP_3 25.41 0.31 4278 478251484 ENN71947.1 1548 8.8e-169 hypothetical protein YQE_11381, partial [Dendroctonus ponderosae] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 796 5.7e-83 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.53456 BP_3 98.72 2.86 1953 478251484 ENN71947.1 1955 2.6e-216 hypothetical protein YQE_11381, partial [Dendroctonus ponderosae] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q8BYF6 903 1.0e-95 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus GN=Slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.53457 BP_3 40.71 0.86 2578 642916135 XP_008190901.1 765 3.3e-78 PREDICTED: PQ-loop repeat-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N755 308 1.3e-26 PQ-loop repeat-containing protein 3 OS=Homo sapiens GN=PQLC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.53463 BP_3 31.02 0.45 3583 642926149 XP_972125.2 1535 2.4e-167 PREDICTED: putative sodium-coupled neutral amino acid transporter 9 [Tribolium castaneum] -- -- -- -- -- K14995 SLC38A9 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14995 Q19425 860 1.8e-90 Sodium-coupled neutral amino acid transporter 9 homolog OS=Caenorhabditis elegans GN=F13H10.3 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53464 BP_3 3709.86 98.67 2104 642926149 XP_972125.2 1613 1.3e-176 PREDICTED: putative sodium-coupled neutral amino acid transporter 9 [Tribolium castaneum] -- -- -- -- -- K14995 SLC38A9 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14995 Q19425 860 1.1e-90 Sodium-coupled neutral amino acid transporter 9 homolog OS=Caenorhabditis elegans GN=F13H10.3 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53468 BP_3 15.35 1.48 790 642914939 XP_008190450.1 419 1.3e-38 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q9HCE1 240 3.1e-19 Putative helicase MOV-10 OS=Homo sapiens GN=MOV10 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1804 RNA helicase Cluster-8309.53469 BP_3 49.18 0.40 6160 270013629 EFA10077.1 299 8.5e-24 hypothetical protein TcasGA2_TC012253 [Tribolium castaneum] -- -- -- -- -- K05668 ABCC5 ATP-binding cassette, subfamily C (CFTR/MRP), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05668 O15440 167 7.1e-10 Multidrug resistance-associated protein 5 OS=Homo sapiens GN=ABCC5 PE=1 SV=2 PF00664//PF01799 ABC transporter transmembrane region//[2Fe-2S] binding domain GO:0055114//GO:0055085//GO:0006810 oxidation-reduction process//transmembrane transport//transport GO:0046872//GO:0042626//GO:0005524//GO:0016491 metal ion binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//oxidoreductase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.53472 BP_3 202.28 2.49 4209 642930416 XP_008196392.1 937 6.1e-98 PREDICTED: stAR-related lipid transfer protein 3 [Tribolium castaneum]>gi|270011106|gb|EFA07554.1| Start1 [Tribolium castaneum] 768450242 XM_011568950.1 44 6.63831e-11 PREDICTED: Plutella xylostella MLN64 N-terminal domain homolog (LOC105396938), mRNA -- -- -- -- Q9DFS4 333 2.7e-29 StAR-related lipid transfer protein 3 OS=Danio rerio GN=stard3 PE=2 SV=2 PF04277//PF01852 Oxaloacetate decarboxylase, gamma chain//START domain GO:0006525//GO:0006560//GO:0071436//GO:0006090//GO:0006814 arginine metabolic process//proline metabolic process//sodium ion export//pyruvate metabolic process//sodium ion transport GO:0008289//GO:0008948//GO:0015081 lipid binding//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane KOG3845 MLN, STAR and related lipid-binding proteins Cluster-8309.53473 BP_3 386.08 11.75 1875 91079600 XP_968514.1 1115 6.2e-119 PREDICTED: transcription initiation factor TFIID subunit 7 [Tribolium castaneum]>gi|270004463|gb|EFA00911.1| hypothetical protein TcasGA2_TC003817 [Tribolium castaneum] -- -- -- -- -- K03132 TAF7 transcription initiation factor TFIID subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03132 Q9VHY5 467 3.5e-45 Transcription initiation factor TFIID subunit 7 OS=Drosophila melanogaster GN=Taf7 PE=1 SV=1 PF04658 TAFII55 protein conserved region GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005669 transcription factor TFIID complex KOG4011 Transcription initiation factor TFIID, subunit TAF7 Cluster-8309.53474 BP_3 19.43 0.50 2166 546676986 ERL87910.1 449 1.2e-41 hypothetical protein D910_05298 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96S94 346 4.4e-31 Cyclin-L2 OS=Homo sapiens GN=CCNL2 PE=1 SV=1 PF02984//PF11547//PF05460 Cyclin, C-terminal domain//E3 ubiquitin ligase EDD//Origin recognition complex subunit 6 (ORC6) GO:0006260 DNA replication GO:0003677//GO:0043130 DNA binding//ubiquitin binding GO:0005634//GO:0005664 nucleus//nuclear origin of replication recognition complex KOG0835 Cyclin L Cluster-8309.53475 BP_3 343.06 11.62 1715 270015507 EFA11955.1 515 2.1e-49 hypothetical protein TcasGA2_TC008556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EQ28 214 7.0e-16 DNA polymerase delta subunit 3 OS=Mus musculus GN=Pold3 PE=1 SV=2 PF09507//PF17079//PF08689 DNA polymerase subunit Cdc27//Male-specific protein scotti//Mediator complex subunit Med5 GO:0006357//GO:0006260//GO:0007291 regulation of transcription from RNA polymerase II promoter//DNA replication//sperm individualization GO:0001104 RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592 nucleus//mediator complex -- -- Cluster-8309.53476 BP_3 184.90 2.70 3594 642929960 XP_008196043.1 1035 2.3e-109 PREDICTED: uncharacterized protein LOC661554 [Tribolium castaneum] -- -- -- -- -- K07819 B3GALT1 beta-1,3-galactosyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07819 Q9Y5Z6 431 1.0e-40 Beta-1,3-galactosyltransferase 1 OS=Homo sapiens GN=B3GALT1 PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane -- -- Cluster-8309.53477 BP_3 544.09 5.58 4989 642934662 XP_008197757.1 4150 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X4 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.01204e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 659 5.1e-67 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF08727 PDZ domain (Also known as DHR or GLGF)//Poliovirus 3A protein like GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0017111//GO:0005515//GO:0004197//GO:0003968 nucleoside-triphosphatase activity//protein binding//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.53479 BP_3 120.35 0.91 6700 102939 2480 1.2e-276 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1452 7.7e-159 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683//PF03839 Integrase core domain//Integrase core domain//Translocation protein Sec62 GO:0015031//GO:0015074 protein transport//DNA integration GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.53480 BP_3 123.00 0.57 10678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845//PF04706 Spore germination protein//Dickkopf N-terminal cysteine-rich region GO:0009847//GO:0030178//GO:0007275 spore germination//negative regulation of Wnt signaling pathway//multicellular organismal development -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.53486 BP_3 167.63 1.30 6498 642924039 XP_008193981.1 1498 8.4e-163 PREDICTED: synaptic vesicle 2-related protein [Tribolium castaneum] 642924038 XM_008195759.1 265 1.44062e-133 PREDICTED: Tribolium castaneum synaptic vesicle 2-related protein (LOC100142592), mRNA -- -- -- -- Q9Z2I7 896 2.2e-94 Synaptic vesicle 2-related protein OS=Rattus norvegicus GN=Svop PE=1 SV=1 PF13417//PF00701//PF00083//PF02798//PF07690//PF13409 Glutathione S-transferase, N-terminal domain//Dihydrodipicolinate synthetase family//Sugar (and other) transporter//Glutathione S-transferase, N-terminal domain//Major Facilitator Superfamily//Glutathione S-transferase, N-terminal domain GO:0055085//GO:0008152 transmembrane transport//metabolic process GO:0005515//GO:0016829//GO:0022857 protein binding//lyase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0253 Synaptic vesicle transporter SV2 (major facilitator superfamily) Cluster-8309.53487 BP_3 505.55 3.38 7504 91077676 XP_974586.1 2692 3.4e-301 PREDICTED: E3 ubiquitin-protein ligase RFWD2 isoform X1 [Tribolium castaneum]>gi|270001535|gb|EEZ97982.1| hypothetical protein TcasGA2_TC000377 [Tribolium castaneum] 821479846 XM_012547670.1 46 9.17963e-12 PREDICTED: Sarcophilus harrisii ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2), mRNA K10143 RFWD2, COP1 E3 ubiquitin-protein ligase RFWD2 http://www.genome.jp/dbget-bin/www_bget?ko:K10143 Q8NHY2 1693 9.7e-187 E3 ubiquitin-protein ligase RFWD2 OS=Homo sapiens GN=RFWD2 PE=1 SV=1 PF00097//PF12678//PF00883//PF04564//PF14634//PF02789//PF13639//PF16685//PF00048//PF00400//PF03823 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//Cytosol aminopeptidase family, catalytic domain//U-box domain//zinc-RING finger domain//Cytosol aminopeptidase family, N-terminal domain//Ring finger domain//zinc RING finger of MSL2//Small cytokines (intecrine/chemokine), interleukin-8 like//WD domain, G-beta repeat//Neurokinin B GO:0016567//GO:0006935//GO:0007165//GO:0007217//GO:0006508//GO:0006955 protein ubiquitination//chemotaxis//signal transduction//tachykinin receptor signaling pathway//proteolysis//immune response GO:0005515//GO:0061630//GO:0004842//GO:0008009//GO:0046872//GO:0004177//GO:0008270 protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//chemokine activity//metal ion binding//aminopeptidase activity//zinc ion binding GO:0005622//GO:0005576 intracellular//extracellular region -- -- Cluster-8309.53488 BP_3 1.00 2.72 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53490 BP_3 17.00 0.95 1154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53493 BP_3 1375.87 20.43 3537 642932696 XP_008196948.1 1875 8.8e-207 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371//PF06330//PF02183//PF06367//PF10473//PF00926 Diaphanous GTPase-binding Domain//Trichodiene synthase (TRI5)//Homeobox associated leucine zipper//Diaphanous FH3 Domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//3,4-dihydroxy-2-butanone 4-phosphate synthase GO:0009231//GO:0016043//GO:0006355//GO:0030036//GO:0016106//GO:0016114 riboflavin biosynthetic process//cellular component organization//regulation of transcription, DNA-templated//actin cytoskeleton organization//sesquiterpenoid biosynthetic process//terpenoid biosynthetic process GO:0042803//GO:0017048//GO:0045482//GO:0043565//GO:0003700//GO:0008686//GO:0045502//GO:0003779//GO:0008134 protein homodimerization activity//Rho GTPase binding//trichodiene synthase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//3,4-dihydroxy-2-butanone-4-phosphate synthase activity//dynein binding//actin binding//transcription factor binding GO:0030286//GO:0005667 dynein complex//transcription factor complex -- -- Cluster-8309.53494 BP_3 71.27 3.69 1222 332374338 AEE62310.1 832 2.7e-86 unknown [Dendroctonus ponderosae] 768911272 XM_003962159.2 72 5.14141e-27 PREDICTED: Takifugu rubripes ADP-ribosylation factor-like 5A (arl5a), mRNA K07950 ARL5B ADP-ribosylation factor-like protein 5B http://www.genome.jp/dbget-bin/www_bget?ko:K07950 Q9D4P0 695 8.4e-72 ADP-ribosylation factor-like protein 5B OS=Mus musculus GN=Arl5b PE=2 SV=3 PF08477//PF01926//PF03661//PF02421//PF00025//PF00503//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Uncharacterised protein family (UPF0121)//Ferrous iron transport protein B//ADP-ribosylation factor family//G-protein alpha subunit//Gtr1/RagA G protein conserved region//Ras family GO:0007186//GO:0007264//GO:0015684//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//ferrous iron transport//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0015093//GO:0031683//GO:0003924 GTP binding//signal transducer activity//guanyl nucleotide binding//ferrous iron transmembrane transporter activity//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.53497 BP_3 117.06 4.27 1612 91082413 XP_976289.1 522 3.1e-50 PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922599|ref|XP_008193242.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922601|ref|XP_008193243.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922603|ref|XP_008193244.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922605|ref|XP_008193245.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922607|ref|XP_008193246.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|270007164|gb|EFA03612.1| hypothetical protein TcasGA2_TC013700 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.535 BP_3 9.00 1.21 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53503 BP_3 6.00 0.34 1132 795010007 XP_011864749.1 247 1.7e-18 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53509 BP_3 2013.35 42.46 2577 91085409 XP_967434.1 861 2.4e-89 PREDICTED: prostatic acid phosphatase [Tribolium castaneum]>gi|270009157|gb|EFA05605.1| hypothetical protein TcasGA2_TC015811 [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 B1H1P9 622 5.2e-63 Lysosomal acid phosphatase OS=Xenopus laevis GN=acp2 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.53511 BP_3 49.49 0.69 3734 642929042 XP_973795.3 1248 4.7e-134 PREDICTED: homeobox protein Nkx-2.1-like [Tribolium castaneum] 736214483 XM_010779878.1 99 1.56763e-41 PREDICTED: Notothenia coriiceps NK2 homeobox 4 (nkx2-4), transcript variant X2, mRNA K09342 NKX2-1, TITF1 homeobox protein Nkx-2.1 http://www.genome.jp/dbget-bin/www_bget?ko:K09342 P23441 388 1.0e-35 Homeobox protein Nkx-2.1 OS=Rattus norvegicus GN=Nkx2-1 PE=1 SV=1 PF13374//PF00046 Tetratricopeptide repeat//Homeobox domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain Cluster-8309.53512 BP_3 35.26 0.41 4455 270001097 EEZ97544.1 925 1.6e-96 hypothetical protein TcasGA2_TC011394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08240 Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.53513 BP_3 40.74 0.41 5036 270001097 EEZ97544.1 925 1.8e-96 hypothetical protein TcasGA2_TC011394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08240 Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.53515 BP_3 135.87 0.86 7921 642927844 XP_008195423.1 830 2.9e-85 PREDICTED: INO80 complex subunit D-B-like [Tribolium castaneum]>gi|270010242|gb|EFA06690.1| hypothetical protein TcasGA2_TC009621 [Tribolium castaneum] -- -- -- -- -- K11668 INO80D INO80 complex subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K11668 Q66JY2 239 4.1e-18 INO80 complex subunit D OS=Mus musculus GN=Ino80d PE=2 SV=3 PF06160//PF00397 Septation ring formation regulator, EzrA//WW domain GO:0000921 septin ring assembly GO:0005515 protein binding GO:0016021//GO:0005940 integral component of membrane//septin ring -- -- Cluster-8309.53516 BP_3 385.59 4.67 4273 189239429 XP_974808.2 2351 6.8e-262 PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|642929453|ref|XP_008195847.1| PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|642929455|ref|XP_008195848.1| PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|642929457|ref|XP_008195849.1| PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|270009621|gb|EFA06069.1| hypothetical protein TcasGA2_TC008904 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W31 751 9.4e-78 Zinc finger protein 569 OS=Mus musculus GN=Znf569 PE=2 SV=2 PF01781//PF00096//PF00582//PF02892//PF13912//PF16622//PF13465//PF05443 Ribosomal L38e protein family//Zinc finger, C2H2 type//Universal stress protein family//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein GO:0006355//GO:0042254//GO:0006950//GO:0006412 regulation of transcription, DNA-templated//ribosome biogenesis//response to stress//translation GO:0003735//GO:0008270//GO:0003676//GO:0046872//GO:0003677 structural constituent of ribosome//zinc ion binding//nucleic acid binding//metal ion binding//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.53523 BP_3 452.39 9.14 2678 642910281 XP_008198657.1 2122 1.5e-235 PREDICTED: prolyl 3-hydroxylase 1-like [Tribolium castaneum] -- -- -- -- -- K08134 LEPRE leucine proline-enriched proteoglycan (leprecan) http://www.genome.jp/dbget-bin/www_bget?ko:K08134 Q6JHU7 921 1.1e-97 Prolyl 3-hydroxylase 2 OS=Gallus gallus GN=LEPREL1 PE=2 SV=1 PF00515//PF13640//PF03171//PF13414 Tetratricopeptide repeat//2OG-Fe(II) oxygenase superfamily//2OG-Fe(II) oxygenase superfamily//TPR repeat GO:0055114 oxidation-reduction process GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- -- -- Cluster-8309.53524 BP_3 809.28 15.59 2793 478258925 ENN78905.1 2019 1.4e-223 hypothetical protein YQE_04643, partial [Dendroctonus ponderosae] -- -- -- -- -- K17923 SNX9_18_33 sorting nexin-9/18/33 http://www.genome.jp/dbget-bin/www_bget?ko:K17923 Q8I4E2 883 3.0e-93 Sorting nexin lst-4 OS=Caenorhabditis elegans GN=lst-4 PE=1 SV=1 PF00787//PF00018//PF14604 PX domain//SH3 domain//Variant SH3 domain -- -- GO:0035091//GO:0005515 phosphatidylinositol binding//protein binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.53525 BP_3 36.31 0.46 4131 270003759 EFA00207.1 1137 3.9e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.93006e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.6e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.53532 BP_3 116.00 0.66 8769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53533 BP_3 571.87 7.26 4090 189234120 XP_968578.2 856 1.5e-88 PREDICTED: tetraspanin-13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17356 TSPAN13_31 tetraspanin-13/31 http://www.genome.jp/dbget-bin/www_bget?ko:K17356 Q5XHG6 450 7.2e-43 Tetraspanin-31-A OS=Xenopus laevis GN=tspan31-a PE=2 SV=1 PF11837//PF00335//PF07574//PF11654//PF00076 Domain of unknown function (DUF3357)//Tetraspanin family//Nse1 non-SMC component of SMC5-6 complex//Protein of unknown function (DUF2665)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006012//GO:0005985//GO:0005982//GO:0006281//GO:0009306 galactose metabolic process//sucrose metabolic process//starch metabolic process//DNA repair//protein secretion GO:0004575//GO:0003676//GO:0004564 sucrose alpha-glucosidase activity//nucleic acid binding//beta-fructofuranosidase activity GO:0030915//GO:0016021//GO:0017177 Smc5-Smc6 complex//integral component of membrane//glucosidase II complex KOG4208 Nucleolar RNA-binding protein NIFK Cluster-8309.53534 BP_3 309.00 53.32 571 21617525 AAM66719.1 534 4.4e-52 larval cuticle protein 12.6 [Apriona germari] -- -- -- -- -- -- -- -- -- O02387 248 2.7e-20 Larval cuticle protein LCP-17 OS=Bombyx mori GN=LCP17 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.53535 BP_3 265.14 2.54 5315 242008211 XP_002424904.1 2464 6.6e-275 zinc finger protein, putative [Pediculus humanus corporis]>gi|212508484|gb|EEB12166.1| zinc finger protein, putative [Pediculus humanus corporis] 817192597 XM_012416318.1 430 0 PREDICTED: Orussus abietinus zinc finger protein 665-like (LOC105695064), transcript variant X6, mRNA -- -- -- -- P51523 1365 7.4e-149 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF13912//PF06467 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0008270//GO:0005488 metal ion binding//zinc ion binding//binding -- -- -- -- Cluster-8309.53537 BP_3 28.60 0.95 1741 91094771 XP_967866.1 1686 3.5e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.4e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.53539 BP_3 38.59 0.44 4539 91082023 XP_970243.1 884 9.2e-92 PREDICTED: 39S ribosomal protein L47, mitochondrial [Tribolium castaneum]>gi|270007306|gb|EFA03754.1| hypothetical protein TcasGA2_TC013863 [Tribolium castaneum] -- -- -- -- -- K17428 MRPL47, NCM1 large subunit ribosomal protein L47 http://www.genome.jp/dbget-bin/www_bget?ko:K17428 Q9HD33 443 5.2e-42 39S ribosomal protein L47, mitochondrial OS=Homo sapiens GN=MRPL47 PE=1 SV=2 PF06984 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005761 ribosome//mitochondrial ribosome KOG3331 Mitochondrial/chloroplast ribosomal protein L4/L29 Cluster-8309.53541 BP_3 7.68 0.44 1130 795010952 XP_011869921.1 441 5.4e-41 PREDICTED: putative nuclease HARBI1 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q6AZB8 247 6.9e-20 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53542 BP_3 10.08 0.39 1527 189238464 XP_966906.2 779 4.6e-80 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q8CEC6 590 1.6e-59 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Mus musculus GN=Ppwd1 PE=2 SV=2 PF06470 SMC proteins Flexible Hinge Domain GO:0051276 chromosome organization GO:0005515//GO:0005524 protein binding//ATP binding GO:0005694 chromosome KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.53543 BP_3 44.00 10.58 492 270009040 EFA05488.1 809 5.0e-84 hypothetical protein TcasGA2_TC015673 [Tribolium castaneum] 817195439 XM_012417832.1 131 3.16809e-60 PREDICTED: Orussus abietinus peptidylprolyl isomerase domain and WD repeat-containing protein 1 (LOC105695851), transcript variant X2, mRNA K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q29RZ2 683 8.3e-71 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Bos taurus GN=PPWD1 PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0881 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.53544 BP_3 148.62 4.80 1783 189238464 XP_966906.2 1975 1.1e-218 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q8CEC6 1468 2.8e-161 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Mus musculus GN=Ppwd1 PE=2 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.53547 BP_3 1.00 2.28 291 478259707 ENN79551.1 134 5.5e-06 hypothetical protein YQE_04013, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53550 BP_3 11.00 0.60 1175 642924860 XP_008194071.1 296 3.6e-24 PREDICTED: uncharacterized protein LOC656855 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53553 BP_3 5.00 0.86 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53556 BP_3 1.00 2.17 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53557 BP_3 2.00 1.48 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53559 BP_3 18.88 34.80 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53560 BP_3 274.00 33.24 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53562 BP_3 912.68 9.25 5045 642919181 XP_008191771.1 3088 0.0e+00 PREDICTED: uncharacterized protein LOC103312580 isoform X1 [Tribolium castaneum]>gi|270005582|gb|EFA02030.1| hypothetical protein TcasGA2_TC007655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5357 BP_3 132.95 7.08 1197 642932906 XP_008197181.1 1459 5.1e-159 PREDICTED: replication factor C subunit 5 [Tribolium castaneum] -- -- -- -- -- K10756 RFC3_5 replication factor C subunit 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10756 P40937 1212 9.2e-132 Replication factor C subunit 5 OS=Homo sapiens GN=RFC5 PE=1 SV=1 PF07726//PF02562//PF04851//PF00270//PF01695//PF07728//PF05496//PF06068//PF00004//PF06144 ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//DNA polymerase III, delta subunit GO:0006310//GO:0006260//GO:0006281 DNA recombination//DNA replication//DNA repair GO:0009378//GO:0016887//GO:0003676//GO:0003887//GO:0003678//GO:0005524//GO:0016787//GO:0003677 four-way junction helicase activity//ATPase activity//nucleic acid binding//DNA-directed DNA polymerase activity//DNA helicase activity//ATP binding//hydrolase activity//DNA binding GO:0042575//GO:0005657//GO:0009379//GO:0009360 DNA polymerase complex//replication fork//Holliday junction helicase complex//DNA polymerase III complex KOG0990 Replication factor C, subunit RFC5 Cluster-8309.53573 BP_3 270.06 1.51 8901 478256070 ENN76269.1 1358 2.0e-146 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 268 2.0e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF06220//PF06657//PF01025//PF00866//PF03623//PF05837//PF01008//PF10473//PF04508//PF01576//PF00170//PF16331//PF04111//PF07851 U1 zinc finger//Centrosome microtubule-binding domain of Cep57//GrpE//Ring hydroxylating beta subunit//Focal adhesion targeting region//Centromere protein H (CENP-H)//Initiation factor 2 subunit family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Viral A-type inclusion protein repeat//Myosin tail//bZIP transcription factor//TolA binding protein trimerisation//Autophagy protein Apg6//TMPIT-like protein GO:0006457//GO:0006355//GO:0006914//GO:0006468//GO:0070206//GO:0007165//GO:0006725//GO:0007172//GO:0016032//GO:0055114//GO:0044237//GO:0051382 protein folding//regulation of transcription, DNA-templated//autophagy//protein phosphorylation//protein trimerization//signal transduction//cellular aromatic compound metabolic process//signal complex assembly//viral process//oxidation-reduction process//cellular metabolic process//kinetochore assembly GO:0042803//GO:0008017//GO:0004871//GO:0003824//GO:0004713//GO:0008270//GO:0043565//GO:0000774//GO:0003774//GO:0003700//GO:0051087//GO:0045502//GO:0008134 protein homodimerization activity//microtubule binding//signal transducer activity//catalytic activity//protein tyrosine kinase activity//zinc ion binding//sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//motor activity//transcription factor activity, sequence-specific DNA binding//chaperone binding//dynein binding//transcription factor binding GO:0016021//GO:0016459//GO:0000776//GO:0005667//GO:0030286//GO:0045298//GO:0005925 integral component of membrane//myosin complex//kinetochore//transcription factor complex//dynein complex//tubulin complex//focal adhesion -- -- Cluster-8309.53574 BP_3 135.28 1.46 4758 478256070 ENN76269.1 798 9.1e-82 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P43047 154 1.8e-08 Uncharacterized protein MCAP_0864 OS=Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154) GN=MCAP_0864 PE=3 SV=2 PF04977//PF06558//PF05524//PF04508//PF00170//PF00866//PF03623//PF05837//PF01008//PF10473//PF06657//PF06220//PF01025 Septum formation initiator//Secretion monitor precursor protein (SecM)//PEP-utilising enzyme, N-terminal//Viral A-type inclusion protein repeat//bZIP transcription factor//Ring hydroxylating beta subunit//Focal adhesion targeting region//Centromere protein H (CENP-H)//Initiation factor 2 subunit family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosome microtubule-binding domain of Cep57//U1 zinc finger//GrpE GO:0006725//GO:0006457//GO:0016032//GO:0007172//GO:0006355//GO:0009401//GO:0055114//GO:0007049//GO:0007165//GO:0051382//GO:0006468//GO:0044237 cellular aromatic compound metabolic process//protein folding//viral process//signal complex assembly//regulation of transcription, DNA-templated//phosphoenolpyruvate-dependent sugar phosphotransferase system//oxidation-reduction process//cell cycle//signal transduction//kinetochore assembly//protein phosphorylation//cellular metabolic process GO:0042803//GO:0008017//GO:0004871//GO:0004713//GO:0003824//GO:0043565//GO:0051087//GO:0008270//GO:0000774//GO:0003700//GO:0045182//GO:0008134//GO:0045502 protein homodimerization activity//microtubule binding//signal transducer activity//protein tyrosine kinase activity//catalytic activity//sequence-specific DNA binding//chaperone binding//zinc ion binding//adenyl-nucleotide exchange factor activity//transcription factor activity, sequence-specific DNA binding//translation regulator activity//transcription factor binding//dynein binding GO:0000776//GO:0030286//GO:0005667//GO:0005925//GO:0045298 kinetochore//dynein complex//transcription factor complex//focal adhesion//tubulin complex -- -- Cluster-8309.53575 BP_3 87.53 0.47 9246 478256070 ENN76269.1 1358 2.0e-146 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 268 2.1e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF03233//PF04559//PF06305//PF05837//PF04508//PF14822//PF16331//PF07851//PF04977//PF00769//PF01025//PF07716//PF06220//PF01008//PF03623//PF10473//PF00866//PF08919//PF03462//PF00170//PF06005//PF01576//PF04111 Aphid transmission protein//Herpesvirus UL17 protein//Protein of unknown function (DUF1049)//Centromere protein H (CENP-H)//Viral A-type inclusion protein repeat//Vasohibin//TolA binding protein trimerisation//TMPIT-like protein//Septum formation initiator//Ezrin/radixin/moesin family//GrpE//Basic region leucine zipper//U1 zinc finger//Initiation factor 2 subunit family//Focal adhesion targeting region//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Ring hydroxylating beta subunit//F-actin binding//PCRF domain//bZIP transcription factor//Protein of unknown function (DUF904)//Myosin tail//Autophagy protein Apg6 GO:0006355//GO:0045765//GO:0007049//GO:0006323//GO:0007165//GO:0006914//GO:0006468//GO:0070206//GO:0043093//GO:0000917//GO:0006449//GO:0006457//GO:0006415//GO:0055114//GO:0051382//GO:0044237//GO:0006725//GO:0016032//GO:0019089//GO:0007172 regulation of transcription, DNA-templated//regulation of angiogenesis//cell cycle//DNA packaging//signal transduction//autophagy//protein phosphorylation//protein trimerization//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of translational termination//protein folding//translational termination//oxidation-reduction process//kinetochore assembly//cellular metabolic process//cellular aromatic compound metabolic process//viral process//transmission of virus//signal complex assembly GO:0008270//GO:0043565//GO:0000774//GO:0042803//GO:0004871//GO:0003824//GO:0004713//GO:0004715//GO:0016149//GO:0051087//GO:0003700//GO:0005524//GO:0045502//GO:0008134//GO:0003774//GO:0008092 zinc ion binding//sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//protein homodimerization activity//signal transducer activity//catalytic activity//protein tyrosine kinase activity//non-membrane spanning protein tyrosine kinase activity//translation release factor activity, codon specific//chaperone binding//transcription factor activity, sequence-specific DNA binding//ATP binding//dynein binding//transcription factor binding//motor activity//cytoskeletal protein binding GO:0005840//GO:0005737//GO:0016021//GO:0005887//GO:0016459//GO:0019012//GO:0018444//GO:0019898//GO:0005925//GO:0000776//GO:0030286//GO:0005667 ribosome//cytoplasm//integral component of membrane//integral component of plasma membrane//myosin complex//virion//translation release factor complex//extrinsic component of membrane//focal adhesion//kinetochore//dynein complex//transcription factor complex -- -- Cluster-8309.53577 BP_3 22.67 1.37 1089 478256070 ENN76269.1 330 3.8e-28 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01025//PF00170//PF06657//PF03938//PF07851//PF04111 GrpE//bZIP transcription factor//Centrosome microtubule-binding domain of Cep57//Outer membrane protein (OmpH-like)//TMPIT-like protein//Autophagy protein Apg6 GO:0006355//GO:0006914//GO:0006457 regulation of transcription, DNA-templated//autophagy//protein folding GO:0003700//GO:0043565//GO:0051087//GO:0042803//GO:0051082//GO:0000774//GO:0008017 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//chaperone binding//protein homodimerization activity//unfolded protein binding//adenyl-nucleotide exchange factor activity//microtubule binding GO:0005667//GO:0045298//GO:0016021 transcription factor complex//tubulin complex//integral component of membrane -- -- Cluster-8309.53578 BP_3 516.96 7.76 3504 91083291 XP_974527.1 4089 0.0e+00 PREDICTED: exostosin-3 [Tribolium castaneum]>gi|270006943|gb|EFA03391.1| hypothetical protein TcasGA2_TC013377 [Tribolium castaneum] 571553454 XM_006564456.1 197 4.89167e-96 PREDICTED: Apis mellifera tripeptidyl-peptidase 2 (TppII), mRNA K02370 EXTL3 alpha-1,4-N-acetylglucosaminyltransferase EXTL3 http://www.genome.jp/dbget-bin/www_bget?ko:K02370 Q9XZ08 3068 0.0e+00 Exostosin-3 OS=Drosophila melanogaster GN=botv PE=1 SV=1 PF09258//PF08300//PF05615//PF04111 Glycosyl transferase family 64 domain//Hepatitis C virus non-structural 5a zinc finger domain//Tho complex subunit 7//Autophagy protein Apg6 GO:0015012//GO:0006397//GO:0006024//GO:0006914 heparan sulfate proteoglycan biosynthetic process//mRNA processing//glycosaminoglycan biosynthetic process//autophagy GO:0016758//GO:0008270 transferase activity, transferring hexosyl groups//zinc ion binding GO:0016021//GO:0031227//GO:0000445 integral component of membrane//intrinsic component of endoplasmic reticulum membrane//THO complex part of transcription export complex KOG1022 Acetylglucosaminyltransferase EXT2/exostosin 2 Cluster-8309.53582 BP_3 81.01 1.73 2551 91092950 XP_972452.1 1657 1.2e-181 PREDICTED: probable glutamine--tRNA ligase [Tribolium castaneum]>gi|270003024|gb|EEZ99471.1| hypothetical protein TcasGA2_TC000042 [Tribolium castaneum] 815821208 XM_012376424.1 119 8.13179e-53 PREDICTED: Linepithema humile probable glutamine--tRNA ligase (LOC105677665), mRNA K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 1494 3.9e-164 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 PF07499//PF04558//PF04557//PF03950//PF00749 RuvA, C-terminal domain//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//tRNA synthetases class I (E and Q), anti-codon binding domain//tRNA synthetases class I (E and Q), catalytic domain GO:0006281//GO:0006418//GO:0006310//GO:0006425//GO:0043039 DNA repair//tRNA aminoacylation for protein translation//DNA recombination//glutaminyl-tRNA aminoacylation//tRNA aminoacylation GO:0005524//GO:0000166//GO:0004819//GO:0009378//GO:0016876//GO:0004812 ATP binding//nucleotide binding//glutamine-tRNA ligase activity//four-way junction helicase activity//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity GO:0005657//GO:0009379//GO:0005737 replication fork//Holliday junction helicase complex//cytoplasm KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.53584 BP_3 344.18 4.49 3983 282721016 NP_001164208.1 2435 1.1e-271 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 6.0e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF00646//PF12125//PF00400//PF15324//PF12937 F-box domain//D domain of beta-TrCP//WD domain, G-beta repeat//Hedgehog signalling target//F-box-like GO:0007224 smoothened signaling pathway GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.53585 BP_3 106.91 0.44 12062 642935135 XP_008197902.1 8205 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13B isoform X1 [Tribolium castaneum] -- -- -- -- -- K19526 VPS13B vacuolar protein sorting-associated protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K19526 Q80TY5 1024 5.9e-109 Vacuolar protein sorting-associated protein 13B OS=Mus musculus GN=Vps13b PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.53587 BP_3 43.51 0.39 5603 478257240 ENN77403.1 2422 5.2e-270 hypothetical protein YQE_06228, partial [Dendroctonus ponderosae] 768451728 XM_011569773.1 111 5.03658e-48 PREDICTED: Plutella xylostella GTPase-activating protein-like (LOC105397755), partial mRNA K12380 RASA3 Ras GTPase-activating protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12380 P48423 1537 8.9e-169 GTPase-activating protein OS=Drosophila melanogaster GN=RasGAP1 PE=1 SV=2 PF00616//PF00779 GTPase-activator protein for Ras-like GTPase//BTK motif GO:0043087//GO:0035556 regulation of GTPase activity//intracellular signal transduction -- -- -- -- KOG2059 Ras GTPase-activating protein Cluster-8309.53590 BP_3 144.95 20.00 641 270002181 EEZ98628.1 466 3.8e-44 hypothetical protein TcasGA2_TC001151, partial [Tribolium castaneum] -- -- -- -- -- K18168 SDHAF2, SDH5 succinate dehydrogenase assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18168 B4GDB3 385 3.9e-36 Succinate dehydrogenase assembly factor 2-A, mitochondrial OS=Drosophila persimilis GN=GL10881 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3326 Uncharacterized conserved protein Cluster-8309.53591 BP_3 39.32 0.82 2608 91089303 XP_971648.1 2595 2.1e-290 PREDICTED: cationic amino acid transporter 4 isoform X1 [Tribolium castaneum]>gi|270012508|gb|EFA08956.1| hypothetical protein TcasGA2_TC006663 [Tribolium castaneum] -- -- -- -- -- K13866 SLC7A4 solute carrier family 7 (cationic amino acid transporter), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13866 Q8BLQ7 1302 7.4e-142 Cationic amino acid transporter 4 OS=Mus musculus GN=Slc7a4 PE=2 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0006865//GO:0003333//GO:0055085//GO:0006810 amino acid transport//amino acid transmembrane transport//transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1286 Amino acid transporters Cluster-8309.53592 BP_3 10.81 0.37 1691 91078258 XP_970899.1 942 6.4e-99 PREDICTED: conserved oligomeric Golgi complex subunit 6 [Tribolium castaneum]>gi|270003921|gb|EFA00369.1| hypothetical protein TcasGA2_TC003211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V564 760 3.4e-79 Conserved oligomeric Golgi complex subunit 6 OS=Drosophila melanogaster GN=CG1968 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3758 Uncharacterized conserved protein Cluster-8309.53593 BP_3 15.15 2.38 599 189239794 XP_969790.2 307 9.8e-26 PREDICTED: histone-lysine N-methyltransferase eggless-like [Tribolium castaneum]>gi|642930862|ref|XP_008196116.1| PREDICTED: histone-lysine N-methyltransferase eggless-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KD2 130 1.3e-06 Histone-lysine N-methyltransferase eggless OS=Drosophila melanogaster GN=egg PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53595 BP_3 19.00 1.47 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53597 BP_3 41.46 1.25 1891 642911140 XP_008200597.1 608 3.9e-60 PREDICTED: protein phosphatase 1 regulatory subunit SDS22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IIW9 144 1.0e-07 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Xenopus tropicalis GN=lingo1 PE=2 SV=1 PF00262//PF00560//PF13855 Calreticulin family//Leucine Rich Repeat//Leucine rich repeat GO:0006457 protein folding GO:0005515//GO:0051082//GO:0005509 protein binding//unfolded protein binding//calcium ion binding GO:0005783 endoplasmic reticulum -- -- Cluster-8309.53599 BP_3 52.45 0.38 6864 91093306 XP_967617.1 1066 1.1e-112 PREDICTED: putative protein FAM10A4 [Tribolium castaneum]>gi|270014189|gb|EFA10637.1| hypothetical protein TcasGA2_TC016274 [Tribolium castaneum] 558226116 XM_006137153.1 62 1.07043e-20 PREDICTED: Pelodiscus sinensis tetratricopeptide repeat domain 1 (TTC1), transcript variant X3, mRNA K09560 ST13 suppressor of tumorigenicity protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09560 Q5ZLF0 702 7.3e-72 Hsc70-interacting protein OS=Gallus gallus GN=ST13 PE=2 SV=1 PF04194//PF13176//PF00522//PF13414//PF13374//PF00515//PF13371//PF13174//PF13181 Programmed cell death protein 2, C-terminal putative domain//Tetratricopeptide repeat//VPR/VPX protein//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019058 viral life cycle GO:0005515 protein binding GO:0042025//GO:0005737 host cell nucleus//cytoplasm KOG1308 Hsp70-interacting protein Hip/Transient component of progesterone receptor complexes and an Hsp70-binding protein Cluster-8309.536 BP_3 31.00 0.96 1846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53604 BP_3 11.00 0.67 1088 861634002 KMQ91126.1 1067 1.3e-113 dna pol b2 domain-containing protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0008408//GO:0003677//GO:0000166//GO:0003887 3'-5' exonuclease activity//DNA binding//nucleotide binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.53607 BP_3 364.94 4.80 3953 478253469 ENN73796.1 2091 8.8e-232 hypothetical protein YQE_09574, partial [Dendroctonus ponderosae] -- -- -- -- -- K08863 PLK4 polo-like kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08863 A2VDZ4 1244 5.9e-135 Serine/threonine-protein kinase PLK4 OS=Bos taurus GN=PLK4 PE=2 SV=1 PF00069//PF00050//PF06293//PF07648//PF07714 Protein kinase domain//Kazal-type serine protease inhibitor domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Kazal-type serine protease inhibitor domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0016773//GO:0005524 protein binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0575 Polo-like serine/threonine protein kinase Cluster-8309.53611 BP_3 8.17 0.51 1071 546681997 ERL91993.1 475 5.8e-45 hypothetical protein D910_09315 [Dendroctonus ponderosae] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 412 4.8e-39 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0170 E3 ubiquitin protein ligase Cluster-8309.53618 BP_3 248.57 3.23 3998 642932892 XP_008197175.1 730 5.8e-74 PREDICTED: uncharacterized protein LOC103314074 [Tribolium castaneum]>gi|270011476|gb|EFA07924.1| hypothetical protein TcasGA2_TC005502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5362 BP_3 3.00 0.58 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53623 BP_3 739.58 6.09 6143 642911905 XP_008199016.1 3231 0.0e+00 PREDICTED: protein pigeon isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24118 1736 8.2e-192 Protein pigeon OS=Drosophila melanogaster GN=pigeon PE=2 SV=2 PF03374//PF15494//PF00278//PF02784 Phage antirepressor protein KilAC domain//Scavenger receptor cysteine-rich domain//Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Pyridoxal-dependent decarboxylase, pyridoxal binding domain -- -- GO:0003677//GO:0003824 DNA binding//catalytic activity GO:0016020 membrane KOG0622 Ornithine decarboxylase Cluster-8309.53625 BP_3 21.00 0.48 2397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53628 BP_3 461.09 5.94 4036 642917674 XP_008193576.1 1251 2.3e-134 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 4-like [Tribolium castaneum] -- -- -- -- -- K15426 PPP4R4 serine/threonine-protein phosphatase 4 regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15426 Q8C0Y0 745 4.4e-77 Serine/threonine-protein phosphatase 4 regulatory subunit 4 OS=Mus musculus GN=Ppp4r4 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3040 Predicted sugar phosphatase (HAD superfamily) Cluster-8309.53629 BP_3 91.97 1.17 4093 642917674 XP_008193576.1 1251 2.3e-134 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 4-like [Tribolium castaneum] -- -- -- -- -- K15426 PPP4R4 serine/threonine-protein phosphatase 4 regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15426 Q8C0Y0 745 4.5e-77 Serine/threonine-protein phosphatase 4 regulatory subunit 4 OS=Mus musculus GN=Ppp4r4 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3040 Predicted sugar phosphatase (HAD superfamily) Cluster-8309.53632 BP_3 9.00 2.22 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53633 BP_3 11.85 0.38 1799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-8309.53635 BP_3 15.83 0.85 1187 642919343 XP_008191832.1 1188 1.3e-127 PREDICTED: alpha-N-acetylglucosaminidase isoform X1 [Tribolium castaneum]>gi|270005801|gb|EFA02249.1| hypothetical protein TcasGA2_TC007912 [Tribolium castaneum] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 844 4.3e-89 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.53639 BP_3 4.00 1.34 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04772 Influenza B matrix protein 2 (BM2) GO:0015992 proton transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.53640 BP_3 715.72 2.38 14809 642914247 XP_008201606.1 18942 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 1554 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10635 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF00028//PF07645//PF00008 Cadherin domain//Calcium-binding EGF domain//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.53642 BP_3 242.00 9.05 1581 332373460 AEE61871.1 968 5.8e-102 unknown [Dendroctonus ponderosae] -- -- -- -- -- K04708 E1.1.1.102 3-dehydrosphinganine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K04708 Q06136 698 4.9e-72 3-ketodihydrosphingosine reductase OS=Homo sapiens GN=KDSR PE=1 SV=1 PF13241//PF02737//PF03435//PF00106//PF12242//PF02882 Putative NAD(P)-binding//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Saccharopine dehydrogenase NADP binding domain//short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0006631//GO:0006552//GO:0008152//GO:0019354//GO:0006633//GO:0018874//GO:0006568//GO:0055114//GO:0006779//GO:0006554//GO:0006550//GO:0006574//GO:0046487//GO:0009396 fatty acid metabolic process//leucine catabolic process//metabolic process//siroheme biosynthetic process//fatty acid biosynthetic process//benzoate metabolic process//tryptophan metabolic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//lysine catabolic process//isoleucine catabolic process//valine catabolic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0003824//GO:0043115//GO:0016491//GO:0003857//GO:0004488 catalytic activity//precorrin-2 dehydrogenase activity//oxidoreductase activity//3-hydroxyacyl-CoA dehydrogenase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG1210 Predicted 3-ketosphinganine reductase Cluster-8309.53646 BP_3 15.38 0.75 1284 607356256 EZA50796.1 660 2.5e-66 Teneurin-3 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- O61307 412 5.8e-39 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF04863 Alliinase EGF-like domain -- -- GO:0016846 carbon-sulfur lyase activity -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.53648 BP_3 10.64 0.37 1695 642929765 XP_008195966.1 1154 1.7e-123 PREDICTED: protein fem-1 homolog B isoform X1 [Tribolium castaneum]>gi|270009534|gb|EFA05982.1| hypothetical protein TcasGA2_TC008808 [Tribolium castaneum] -- -- -- -- -- K10349 FEM1B Fem-1 homolog b http://www.genome.jp/dbget-bin/www_bget?ko:K10349 Q5ZM55 719 1.9e-74 Protein fem-1 homolog B OS=Gallus gallus GN=FEM1B PE=2 SV=1 PF13374 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.53649 BP_3 11.62 0.41 1662 478259051 ENN78994.1 1720 3.9e-189 hypothetical protein YQE_04545, partial [Dendroctonus ponderosae]>gi|546678364|gb|ERL88997.1| hypothetical protein D910_06375 [Dendroctonus ponderosae] 751216179 XM_011162727.1 168 3.03328e-80 PREDICTED: Solenopsis invicta histone acetyltransferase KAT8-like (LOC105196679), mRNA K11308 MYST1, MOF, KAT8 histone acetyltransferase MYST1 http://www.genome.jp/dbget-bin/www_bget?ko:K11308 O02193 970 1.5e-103 Males-absent on the first protein OS=Drosophila melanogaster GN=mof PE=1 SV=1 PF01853 MOZ/SAS family GO:0006355 regulation of transcription, DNA-templated GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.5365 BP_3 2.00 1.63 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53652 BP_3 15.32 1.09 968 751233858 XP_011170631.1 323 2.2e-27 PREDICTED: uncharacterized protein LOC105203526 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53658 BP_3 64.00 2.37 1591 546685244 ERL94771.1 1395 1.8e-151 hypothetical protein D910_12045 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DCC6 795 2.8e-83 Putative GTP-binding protein 6 OS=Xenopus laevis GN=gtpbp6 PE=2 SV=1 PF02421//PF03851//PF04661//PF01637//PF01926//PF00005 Ferrous iron transport protein B//UV-endonuclease UvdE//Poxvirus I3 ssDNA-binding protein//Archaeal ATPase//50S ribosome-binding GTPase//ABC transporter GO:0006289//GO:0015684//GO:0009411 nucleotide-excision repair//ferrous iron transport//response to UV GO:0005525//GO:0016887//GO:0004519//GO:0015093//GO:0005524//GO:0003697 GTP binding//ATPase activity//endonuclease activity//ferrous iron transmembrane transporter activity//ATP binding//single-stranded DNA binding GO:0016021 integral component of membrane KOG0410 Predicted GTP binding protein Cluster-8309.53662 BP_3 2.00 3.23 306 270015668 EFA12116.1 183 1.2e-11 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.53663 BP_3 167.58 4.52 2079 478250264 ENN70764.1 872 1.0e-90 hypothetical protein YQE_12552, partial [Dendroctonus ponderosae]>gi|546685959|gb|ERL95373.1| hypothetical protein D910_12637 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D3D0 235 3.1e-18 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53666 BP_3 9.38 0.81 852 826412606 XP_012543383.1 156 4.5e-08 PREDICTED: uncharacterized protein LOC105840848 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00096 BED zinc finger//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.53668 BP_3 164.73 2.19 3918 546680539 ERL90799.1 921 4.1e-96 hypothetical protein D910_08145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.53669 BP_3 211.09 9.55 1357 91077210 XP_973096.1 1241 1.1e-133 PREDICTED: NAD-dependent protein deacetylase Sirt6 [Tribolium castaneum]>gi|270002055|gb|EEZ98502.1| hypothetical protein TcasGA2_TC001003 [Tribolium castaneum] -- -- -- -- -- K11416 SIRT6, SIR2L6 mono-ADP-ribosyltransferase sirtuin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11416 Q9VH08 1001 3.1e-107 NAD-dependent protein deacetylase Sirt6 OS=Drosophila melanogaster GN=Sirt6 PE=2 SV=1 PF10120//PF02146//PF00205 Thiamine-phosphate synthase//Sir2 family//Thiamine pyrophosphate enzyme, central domain -- -- GO:0004789//GO:0070403//GO:0000287//GO:0030976 thiamine-phosphate diphosphorylase activity//NAD+ binding//magnesium ion binding//thiamine pyrophosphate binding -- -- KOG1905 Class IV sirtuins (SIR2 family) Cluster-8309.53670 BP_3 11.98 1.83 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53672 BP_3 108.91 3.04 2020 91087581 XP_971751.1 857 5.5e-89 PREDICTED: peroxisomal membrane protein PMP34 [Tribolium castaneum]>gi|270009432|gb|EFA05880.1| hypothetical protein TcasGA2_TC008692 [Tribolium castaneum] -- -- -- -- -- K13354 SLC25A17, PMP34 solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17 http://www.genome.jp/dbget-bin/www_bget?ko:K13354 O70579 587 4.6e-59 Peroxisomal membrane protein PMP34 OS=Mus musculus GN=Slc25a17 PE=2 SV=1 PF03201 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase GO:0015948//GO:0055114//GO:0046656 methanogenesis//oxidation-reduction process//folic acid biosynthetic process GO:0047068//GO:0018537 N5,N10-methenyltetrahydromethanopterin hydrogenase activity//coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity GO:0016020 membrane KOG0769 Predicted mitochondrial carrier protein Cluster-8309.53676 BP_3 759.70 11.08 3597 546674389 ERL85776.1 3698 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 642926086 XM_001808290.2 513 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase TAO1 (LOC657810), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 O88664 1304 6.0e-142 Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus GN=Taok1 PE=1 SV=1 PF12474//PF07714//PF00069 Polo kinase kinase//Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.53678 BP_3 29.11 0.33 4589 642926092 XP_008194763.1 1991 4.0e-220 PREDICTED: MAP/microtubule affinity-regulating kinase 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REX1 141 5.5e-07 Serine/threonine-protein kinase SIK2 OS=Pongo abelii GN=SIK2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53681 BP_3 118.00 6.19 1210 242015011 XP_002428172.1 1118 1.8e-119 serine/threonine-protein kinase NIM1, putative [Pediculus humanus corporis]>gi|212512715|gb|EEB15434.1| serine/threonine-protein kinase NIM1, putative [Pediculus humanus corporis] 642926091 XM_008196541.1 428 0 PREDICTED: Tribolium castaneum MAP/microtubule affinity-regulating kinase 3 (LOC100142375), mRNA K19009 SIK3 serine/threonine-protein kinase SIK3 http://www.genome.jp/dbget-bin/www_bget?ko:K19009 Q6NSM8 1031 9.1e-111 Serine/threonine-protein kinase SIK3 homolog OS=Danio rerio GN=zgc:66101 PE=2 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004672//GO:0005524//GO:0004683 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding//calmodulin-dependent protein kinase activity GO:0016020 membrane KOG0586 Serine/threonine protein kinase Cluster-8309.53682 BP_3 303.39 3.98 3965 642926092 XP_008194763.1 2104 2.7e-233 PREDICTED: MAP/microtubule affinity-regulating kinase 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REX1 141 4.7e-07 Serine/threonine-protein kinase SIK2 OS=Pongo abelii GN=SIK2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53683 BP_3 74.00 2.91 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03742 PetN GO:0017004//GO:0006118 cytochrome complex assembly//obsolete electron transport GO:0045158 electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.53691 BP_3 10.00 0.81 888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53694 BP_3 183.30 1.58 5871 642915956 XP_008190826.1 1779 2.0e-195 PREDICTED: LOW QUALITY PROTEIN: protein kinase C, brain isozyme-like [Tribolium castaneum] 759058618 XM_011340249.1 327 4.45469e-168 PREDICTED: Cerapachys biroi protein kinase C, brain isozyme (LOC105280061), transcript variant X3, mRNA K02677 CPKC classical protein kinase C http://www.genome.jp/dbget-bin/www_bget?ko:K02677 P05130 1558 3.4e-171 Protein kinase C, brain isozyme OS=Drosophila melanogaster GN=Pkc53E PE=2 SV=2 PF07714//PF00628//PF07649//PF00069//PF09472//PF00130//PF00168//PF00433//PF06293//PF02150 Protein tyrosine kinase//PHD-finger//C1-like domain//Protein kinase domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//RNA polymerases M/15 Kd subunit GO:0046656//GO:0006468//GO:0009069//GO:0055114//GO:0035556//GO:0016310//GO:0006144//GO:0006351//GO:0015948//GO:0006206 folic acid biosynthetic process//protein phosphorylation//serine family amino acid metabolic process//oxidation-reduction process//intracellular signal transduction//phosphorylation//purine nucleobase metabolic process//transcription, DNA-templated//methanogenesis//pyrimidine nucleobase metabolic process GO:0030269//GO:0003899//GO:0005524//GO:0004674//GO:0047134//GO:0005515//GO:0003677//GO:0004672//GO:0016773 tetrahydromethanopterin S-methyltransferase activity//DNA-directed RNA polymerase activity//ATP binding//protein serine/threonine kinase activity//protein-disulfide reductase activity//protein binding//DNA binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0005730//GO:0016020 nucleolus//membrane KOG0694 Serine/threonine protein kinase Cluster-8309.53696 BP_3 578.47 9.91 3104 546680133 ERL90474.1 1139 1.7e-121 hypothetical protein D910_07823 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P12883 223 1.1e-16 Myosin-7 OS=Homo sapiens GN=MYH7 PE=1 SV=5 PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.53698 BP_3 1.02 0.55 379 642937291 XP_008198773.1 358 7.5e-32 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X2 [Tribolium castaneum]>gi|270000838|gb|EEZ97285.1| hypothetical protein TcasGA2_TC011089 [Tribolium castaneum] -- -- -- -- -- K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53625 307 2.5e-27 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B OS=Drosophila melanogaster GN=alpha-Man-I PE=2 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.5370 BP_3 2.00 3.04 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53702 BP_3 94.97 1.07 4563 642925690 XP_008194671.1 3246 0.0e+00 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2318 2.0e-259 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.53704 BP_3 23.39 0.43 2909 642922052 XP_008193000.1 2069 2.3e-229 PREDICTED: uncharacterized protein LOC662639 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 951 4.1e-101 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF00474//PF09036 Sodium:solute symporter family//Bcr-Abl oncoprotein oligomerisation domain GO:0006810//GO:0016310//GO:0009069//GO:0006468//GO:0055085//GO:0007165 transport//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane transport//signal transduction GO:0004674//GO:0005215//GO:0005096 protein serine/threonine kinase activity//transporter activity//GTPase activator activity GO:0016020 membrane -- -- Cluster-8309.53705 BP_3 170.36 3.21 2852 270007206 EFA03654.1 2120 2.8e-235 hypothetical protein TcasGA2_TC013748 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 985 4.6e-105 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF00474//PF09036 Sodium:solute symporter family//Bcr-Abl oncoprotein oligomerisation domain GO:0007165//GO:0055085//GO:0009069//GO:0006468//GO:0006810//GO:0016310 signal transduction//transmembrane transport//serine family amino acid metabolic process//protein phosphorylation//transport//phosphorylation GO:0004674//GO:0005096//GO:0005215 protein serine/threonine kinase activity//GTPase activator activity//transporter activity GO:0016020 membrane -- -- Cluster-8309.53709 BP_3 37.00 0.64 3070 641664521 XP_008183038.1 488 5.2e-46 PREDICTED: uncharacterized protein LOC103309427 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53710 BP_3 7.00 1.03 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53714 BP_3 54.12 0.62 4490 73765582 AAZ85125.1 3016 0.0e+00 Down Syndrome adhesion molecule splice variant 3.12.3.1 [Tribolium castaneum] 642935244 XM_008199706.1 318 3.42451e-163 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X1, mRNA -- -- -- -- Q9VS29 1291 2.4e-140 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF07354//PF13895//PF16990//PF04110 Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Carbohydrate binding module (family 35)//Ubiquitin-like autophagy protein Apg12 GO:0000045//GO:0007339 autophagosome assembly//binding of sperm to zona pellucida GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0005737//GO:0005576 cytoplasm//extracellular region -- -- Cluster-8309.53715 BP_3 23.19 1.11 1296 642919019 XP_008191698.1 398 6.0e-36 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53717 BP_3 149.91 1.60 4806 642926255 XP_008194846.1 2748 7.0e-308 PREDICTED: kelch-like protein 17 [Tribolium castaneum]>gi|270008515|gb|EFA04963.1| hypothetical protein TcasGA2_TC015037 [Tribolium castaneum] 195029940 XM_001987794.1 64 5.78348e-22 Drosophila grimshawi GH19736 (Dgri\GH19736), mRNA K10454 KLHL17 kelch-like protein 17 (actinfilin) http://www.genome.jp/dbget-bin/www_bget?ko:K10454 Q6TDP3 1717 1.0e-189 Kelch-like protein 17 OS=Mus musculus GN=Klhl17 PE=2 SV=1 PF00884//PF01663//PF00651//PF07646//PF01344 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//BTB/POZ domain//Kelch motif//Kelch motif GO:0008152 metabolic process GO:0005515//GO:0003824//GO:0008484 protein binding//catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.53718 BP_3 39.44 0.41 4917 642926255 XP_008194846.1 2748 7.2e-308 PREDICTED: kelch-like protein 17 [Tribolium castaneum]>gi|270008515|gb|EFA04963.1| hypothetical protein TcasGA2_TC015037 [Tribolium castaneum] 195029940 XM_001987794.1 64 5.91806e-22 Drosophila grimshawi GH19736 (Dgri\GH19736), mRNA K10454 KLHL17 kelch-like protein 17 (actinfilin) http://www.genome.jp/dbget-bin/www_bget?ko:K10454 Q6TDP3 1717 1.1e-189 Kelch-like protein 17 OS=Mus musculus GN=Klhl17 PE=2 SV=1 PF07646//PF00651//PF00884//PF01344 Kelch motif//BTB/POZ domain//Sulfatase//Kelch motif GO:0008152 metabolic process GO:0008484//GO:0005515 sulfuric ester hydrolase activity//protein binding -- -- -- -- Cluster-8309.53720 BP_3 4.00 2.20 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00374 Nickel-dependent hydrogenase -- -- GO:0016151 nickel cation binding -- -- -- -- Cluster-8309.53724 BP_3 7.00 1.38 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53725 BP_3 29.00 1.71 1107 752880489 XP_011257814.1 272 2.1e-21 PREDICTED: putative nuclease HARBI1, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53726 BP_3 4.00 0.72 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53728 BP_3 2.49 0.96 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53730 BP_3 1.00 10.47 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53735 BP_3 73.83 1.54 2607 642914284 XP_008201621.1 1185 6.6e-127 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X1 [Tribolium castaneum] 642914285 XM_008203400.1 279 9.46753e-142 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 6-like (LOC663221), transcript variant X2, mRNA K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 Q8K3P5 681 7.5e-70 CCR4-NOT transcription complex subunit 6 OS=Mus musculus GN=Cnot6 PE=1 SV=2 PF16093 Proteasome assembly chaperone 4 GO:0043248 proteasome assembly -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.53737 BP_3 23.86 0.32 3868 642935895 XP_008198218.1 1387 3.7e-150 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270013255|gb|EFA09703.1| hypothetical protein TcasGA2_TC011836 [Tribolium castaneum] 688627348 LL261331.1 76 9.91592e-29 Echinostoma caproni genome assembly E_caproni_Egypt ,scaffold ECPE_scaffold0027233 K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 Q8NA58 514 2.6e-50 Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 OS=Homo sapiens GN=PNLDC1 PE=2 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.53738 BP_3 81.47 1.39 3113 646722695 KDR23609.1 1885 5.3e-208 Periodic tryptophan protein 2-like protein [Zootermopsis nevadensis] -- -- -- -- -- K14558 PWP2, UTP1 periodic tryptophan protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14558 Q15269 1520 4.6e-167 Periodic tryptophan protein 2 homolog OS=Homo sapiens GN=PWP2 PE=1 SV=2 PF01764//PF08625//PF04053//PF02031//PF00400//PF00930//PF04192//PF09142//PF04617 Lipase (class 3)//Utp13 specific WD40 associated domain//Coatomer WD associated region//Streptomyces extracellular neutral proteinase (M7) family//WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Utp21 specific WD40 associated putative domain//tRNA Pseudouridine synthase II, C terminal//Hox9 activation region GO:0006508//GO:0009451//GO:0006629//GO:0006351//GO:0001522//GO:0006364//GO:0016192//GO:0006886 proteolysis//RNA modification//lipid metabolic process//transcription, DNA-templated//pseudouridine synthesis//rRNA processing//vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003723//GO:0008270//GO:0009982//GO:0005198//GO:0004222 protein binding//RNA binding//zinc ion binding//pseudouridine synthase activity//structural molecule activity//metalloendopeptidase activity GO:0030117//GO:0005576//GO:0005634//GO:0032040 membrane coat//extracellular region//nucleus//small-subunit processome KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.53739 BP_3 34.30 1.46 1426 861588173 KMQ82585.1 435 3.4e-40 transposase-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02262//PF13683 CBL proto-oncogene N-terminal domain 1//Integrase core domain GO:0007166//GO:0015074//GO:0007165 cell surface receptor signaling pathway//DNA integration//signal transduction GO:0004871 signal transducer activity GO:0005634 nucleus -- -- Cluster-8309.53740 BP_3 286.71 3.26 4534 91085249 XP_973267.1 1086 3.5e-115 PREDICTED: thioredoxin-related transmembrane protein 2 homolog [Tribolium castaneum]>gi|270009096|gb|EFA05544.1| hypothetical protein TcasGA2_TC015732 [Tribolium castaneum] 815899095 XM_012394754.1 156 3.928e-73 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 3.2e-92 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF02144//PF00149//PF04139//PF04005//PF00085 Repair protein Rad1/Rec1/Rad17//Calcineurin-like phosphoesterase//Rad9//Hus1-like protein//Thioredoxin GO:0045454//GO:0006281//GO:0000077 cell redox homeostasis//DNA repair//DNA damage checkpoint GO:0016787 hydrolase activity GO:0005634//GO:0030896 nucleus//checkpoint clamp complex KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.53747 BP_3 167.09 4.87 1946 642913383 XP_969242.3 997 3.1e-105 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 666 3.1e-68 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF00326//PF01738 Prolyl oligopeptidase family//Dienelactone hydrolase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2984 Predicted hydrolase Cluster-8309.53748 BP_3 99.00 2.72 2049 642913383 XP_969242.3 997 3.3e-105 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 666 3.2e-68 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF01738//PF00326 Dienelactone hydrolase family//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2984 Predicted hydrolase Cluster-8309.53749 BP_3 84.39 2.34 2028 642913383 XP_969242.3 997 3.2e-105 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 666 3.2e-68 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF00326//PF01738 Prolyl oligopeptidase family//Dienelactone hydrolase family GO:0006508 proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- KOG2984 Predicted hydrolase Cluster-8309.53750 BP_3 11.37 9.97 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53752 BP_3 7.00 7.98 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53756 BP_3 8.97 0.46 1222 167466181 NP_001107846.1 883 3.2e-92 cytochrome P450 monooxigenase CYP4Q2 [Tribolium castaneum]>gi|270014305|gb|EFA10753.1| cytochrome P450-like protein [Tribolium castaneum] 815819218 XM_012375356.1 49 3.13843e-14 PREDICTED: Linepithema humile cytochrome P450 4C1-like (LOC105677043), mRNA K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 P29981 636 5.8e-65 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0046872//GO:0016705 heme binding//iron ion binding//oxidoreductase activity//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.53757 BP_3 240.99 6.76 2011 167466181 NP_001107846.1 1363 1.2e-147 cytochrome P450 monooxigenase CYP4Q2 [Tribolium castaneum]>gi|270014305|gb|EFA10753.1| cytochrome P450-like protein [Tribolium castaneum] 815818840 XM_012375165.1 50 1.45262e-14 PREDICTED: Linepithema humile cytochrome P450 4C1-like (LOC105676933), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1007 9.2e-108 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016491//GO:0005506//GO:0046872//GO:0020037//GO:0016705 oxidoreductase activity//iron ion binding//metal ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.53758 BP_3 434.81 4.78 4678 478250909 ENN71394.1 603 3.6e-59 hypothetical protein YQE_11898, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9QX47 328 1.2e-28 Protein SON OS=Mus musculus GN=Son PE=1 SV=2 PF05493//PF01585 ATP synthase subunit H//G-patch domain GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0003676//GO:0015078 nucleic acid binding//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.5376 BP_3 1.97 0.32 591 270012482 EFA08930.1 244 2.0e-18 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 P23622 156 1.3e-09 Sulfate permease 2 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cys-14 PE=2 SV=3 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.53760 BP_3 51.91 0.90 3057 478255213 ENN75442.1 276 2.0e-21 hypothetical protein YQE_07993, partial [Dendroctonus ponderosae] -- -- -- -- -- K00953 FLAD1 FAD synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00953 Q6ING7 194 2.6e-13 FAD synthase OS=Xenopus laevis GN=flad1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2644 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Cluster-8309.53768 BP_3 284.54 3.99 3732 270003335 EEZ99782.1 1451 1.4e-157 hypothetical protein TcasGA2_TC002561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ERD6 793 1.1e-82 Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Mus musculus GN=Ralgps2 PE=1 SV=2 PF04636//PF05767//PF00617 PA26 p53-induced protein (sestrin)//Poxvirus virion envelope protein A14//RasGEF domain GO:1901031//GO:0007264//GO:0043087 regulation of response to reactive oxygen species//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0019031//GO:0005634 viral envelope//nucleus KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.53772 BP_3 34.93 1.16 1745 642935508 XP_008198038.1 1304 7.0e-141 PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K17617 CTDNEP1, DULLARD, NEM1 CTD nuclear envelope phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17617 Q9VRG7 898 3.5e-95 CTD nuclear envelope phosphatase 1 homolog OS=Drosophila melanogaster GN=Dd PE=2 SV=1 PF06436//PF01621 Pneumovirus matrix protein 2 (M2)//Cell fusion glycoprotein K GO:0046782 regulation of viral transcription GO:0005198 structural molecule activity GO:0016020//GO:0019012 membrane//virion KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.53773 BP_3 99.72 3.19 1800 189241120 XP_973128.2 1177 3.9e-126 PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935513|ref|XP_008198040.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935515|ref|XP_008198041.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K17617 CTDNEP1, DULLARD, NEM1 CTD nuclear envelope phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17617 Q9VRG7 961 1.8e-102 CTD nuclear envelope phosphatase 1 homolog OS=Drosophila melanogaster GN=Dd PE=2 SV=1 PF06436//PF01621 Pneumovirus matrix protein 2 (M2)//Cell fusion glycoprotein K GO:0046782 regulation of viral transcription GO:0005198 structural molecule activity GO:0016020//GO:0019012 membrane//virion KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.53779 BP_3 6.03 0.36 1102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53780 BP_3 17.00 0.46 2064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07415 Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency -- -- GO:0033644 host cell membrane -- -- Cluster-8309.53782 BP_3 28.57 1.55 1183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53783 BP_3 2.00 0.45 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53784 BP_3 22.09 0.56 2178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05320 Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.53789 BP_3 906.29 14.06 3398 642924922 XP_008194098.1 1312 1.6e-141 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMF0 209 5.3e-15 Cordon-bleu protein-like 1 OS=Mus musculus GN=Cobll1 PE=1 SV=2 PF02205//PF02196 WH2 motif//Raf-like Ras-binding domain GO:0007165 signal transduction GO:0003779//GO:0005057 actin binding//receptor signaling protein activity -- -- -- -- Cluster-8309.53794 BP_3 274.03 2.27 6103 189242026 XP_968092.2 2096 3.6e-232 PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938706|ref|XP_008196798.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938708|ref|XP_008196803.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938710|ref|XP_008196809.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938712|ref|XP_008196813.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938715|ref|XP_008196822.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|270015800|gb|EFA12248.1| hypothetical protein TcasGA2_TC016108 [Tribolium castaneum] 675175042 XM_008898158.1 35 9.71977e-06 Phytophthora parasitica INRA-310 hypothetical protein mRNA -- -- -- -- Q96NB2 1019 1.1e-108 Sideroflexin-2 OS=Homo sapiens GN=SFXN2 PE=1 SV=2 PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.53806 BP_3 26.62 0.38 3673 642932046 XP_008196836.1 703 7.3e-71 PREDICTED: uncharacterized protein LOC103313971 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80VL1 172 1.1e-10 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF15802//PF04277 DDB1- and CUL4-associated factor 17//Oxaloacetate decarboxylase, gamma chain GO:0006814//GO:0071436//GO:0006090//GO:0006525//GO:0016567//GO:0006560 sodium ion transport//sodium ion export//pyruvate metabolic process//arginine metabolic process//protein ubiquitination//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.53807 BP_3 64.06 2.39 1584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53808 BP_3 14.62 0.80 1172 642929239 XP_008195748.1 325 1.6e-27 PREDICTED: uncharacterized protein LOC103313667 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01914//PF01284 MarC family integral membrane protein//Membrane-associating domain -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.53810 BP_3 94.39 1.66 3034 270007928 EFA04376.1 272 5.7e-21 hypothetical protein TcasGA2_TC014674 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07688//PF05273 KaiA domain//Poxvirus RNA polymerase 22 kDa subunit GO:0007623//GO:0006468//GO:0006144//GO:0019083//GO:0006351//GO:0006206 circadian rhythm//protein phosphorylation//purine nucleobase metabolic process//viral transcription//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.53818 BP_3 315.23 4.98 3343 642914462 XP_008201687.1 932 1.8e-97 PREDICTED: potassium channel subfamily K member 6-like isoform X1 [Tribolium castaneum]>gi|270001497|gb|EEZ97944.1| hypothetical protein TcasGA2_TC000334 [Tribolium castaneum] -- -- -- -- -- K04912 KCNK1 potassium channel subfamily K member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04912 Q5UE96 439 1.1e-41 Potassium channel subfamily K member 1 OS=Oryctolagus cuniculus GN=KCNK1 PE=2 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.53820 BP_3 16.70 0.36 2515 189236906 XP_001809986.1 1625 6.1e-178 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 781 1.8e-81 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.53825 BP_3 8.00 0.41 1230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53832 BP_3 12.00 0.84 977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53840 BP_3 5.97 0.58 790 607304994 EZA45999.1 364 3.2e-32 NEDD4 family-interacting-like protein, partial [Microplitis demolitor] -- -- -- -- -- -- -- -- -- Q9NV92 186 5.7e-13 NEDD4 family-interacting protein 2 OS=Homo sapiens GN=NDFIP2 PE=1 SV=2 PF10176//PF03137 Protein of unknown function (DUF2370)//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0007034//GO:0030001 transport//vacuolar transport//metal ion transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.53843 BP_3 63.04 0.50 6429 642929566 XP_008195887.1 2710 2.4e-303 PREDICTED: uncharacterized protein LOC664242 isoform X2 [Tribolium castaneum]>gi|270009578|gb|EFA06026.1| hypothetical protein TcasGA2_TC008856 [Tribolium castaneum] 817214723 XM_012428143.1 47 2.18484e-12 PREDICTED: Orussus abietinus GTP-binding protein Rit2 (LOC105701416), partial mRNA -- -- -- -- O88667 266 2.5e-21 GTP-binding protein RAD OS=Mus musculus GN=Rrad PE=1 SV=1 PF01868//PF03390//PF03193//PF01105//PF00071//PF00498//PF08477//PF00025 Domain of unknown function UPF0086//2-hydroxycarboxylate transporter family//Protein of unknown function, DUF258//emp24/gp25L/p24 family/GOLD//Ras family//FHA domain//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family GO:0006364//GO:0051252//GO:0008033//GO:0009987//GO:0006810//GO:0015711//GO:0007264//GO:0006379 rRNA processing//regulation of RNA metabolic process//tRNA processing//cellular process//transport//organic anion transport//small GTPase mediated signal transduction//mRNA cleavage GO:0008514//GO:0003924//GO:0004540//GO:0005525//GO:0003723//GO:0005515 organic anion transmembrane transporter activity//GTPase activity//ribonuclease activity//GTP binding//RNA binding//protein binding GO:0000172//GO:0016021//GO:0030677 ribonuclease MRP complex//integral component of membrane//ribonuclease P complex KOG0395 Ras-related GTPase Cluster-8309.53844 BP_3 1659.66 11.54 7223 642940400 XP_008200547.1 809 7.3e-83 PREDICTED: chitin deacetylase 5 isoform X8 [Tribolium castaneum] 642940399 XM_008202325.1 70 4.02383e-25 PREDICTED: Tribolium castaneum chitin deacetylase 5 (Cda5), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.53845 BP_3 19.05 0.65 1710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53847 BP_3 182.85 3.88 2562 642927466 XP_008195284.1 1271 6.9e-137 PREDICTED: protein arginine N-methyltransferase 6 [Tribolium castaneum] -- -- -- -- -- K11435 PRMT2 protein arginine N-methyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11435 Q6NWG4 602 1.1e-60 Protein arginine N-methyltransferase 6 OS=Danio rerio GN=prmt6 PE=2 SV=2 PF01135//PF05175//PF08241//PF02527//PF03602//PF09243//PF05401//PF05185 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Methyltransferase domain//rRNA small subunit methyltransferase G//Conserved hypothetical protein 95//Mitochondrial small ribosomal subunit Rsm22//Nodulation protein S (NodS)//PRMT5 arginine-N-methyltransferase GO:0031167//GO:0006464//GO:0009312//GO:0000154//GO:0006396//GO:0006364//GO:0006412//GO:0008152//GO:0046500//GO:0009877//GO:0006479 rRNA methylation//cellular protein modification process//oligosaccharide biosynthetic process//rRNA modification//RNA processing//rRNA processing//translation//metabolic process//S-adenosylmethionine metabolic process//nodulation//protein methylation GO:0008168//GO:0008649//GO:0008757//GO:0004719 methyltransferase activity//rRNA methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0005737 cytoplasm KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.53850 BP_3 389.81 8.82 2422 642928221 XP_008195493.1 1550 2.9e-169 PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928223|ref|XP_008195494.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928225|ref|XP_008195495.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928227|ref|XP_008195496.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum] 642928222 XM_008197272.1 484 0 PREDICTED: Tribolium castaneum uncharacterized LOC103313600 (LOC103313600), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF11857 Domain of unknown function (DUF3377) -- -- GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.53858 BP_3 296.09 12.47 1436 91077808 XP_970231.1 636 1.7e-63 PREDICTED: uncharacterized protein LOC658778 [Tribolium castaneum]>gi|270001488|gb|EEZ97935.1| hypothetical protein TcasGA2_TC000323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08917 Transforming growth factor beta receptor 2 ectodomain GO:0016310//GO:0009069//GO:0006468//GO:0007178 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0005524//GO:0046872//GO:0005026 ATP binding//metal ion binding//transforming growth factor beta receptor activity, type II GO:0016020 membrane -- -- Cluster-8309.53859 BP_3 134.49 1.00 6743 642922445 XP_008193172.1 5206 0.0e+00 PREDICTED: uncharacterized protein LOC655273 [Tribolium castaneum] 665794170 XM_008546548.1 48 6.37307e-13 PREDICTED: Microplitis demolitor adenylate cyclase type 8 (LOC103569316), transcript variant X1, mRNA K08048 ADCY8 adenylate cyclase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08048 P40145 1239 3.9e-134 Adenylate cyclase type 8 OS=Homo sapiens GN=ADCY8 PE=1 SV=1 PF07701//PF06327//PF00211 Heme NO binding associated//Domain of Unknown Function (DUF1053)//Adenylate and Guanylate cyclase catalytic domain GO:0046039//GO:0006182//GO:0006144//GO:0006171//GO:0009190//GO:0035556 GTP metabolic process//cGMP biosynthetic process//purine nucleobase metabolic process//cAMP biosynthetic process//cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0004383//GO:0016849//GO:0004016 guanylate cyclase activity//phosphorus-oxygen lyase activity//adenylate cyclase activity GO:0005886 plasma membrane -- -- Cluster-8309.53864 BP_3 17.70 0.48 2054 91085771 XP_974257.1 517 1.5e-49 PREDICTED: cyclic AMP-dependent transcription factor ATF-7 [Tribolium castaneum]>gi|270010124|gb|EFA06572.1| hypothetical protein TcasGA2_TC009483 [Tribolium castaneum] -- -- -- -- -- K04450 ATF2, CREBP1 cyclic AMP-dependent transcription factor ATF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04450 P16951 242 4.8e-19 Cyclic AMP-dependent transcription factor ATF-2 OS=Mus musculus GN=Atf2 PE=1 SV=2 PF07716//PF00170//PF00096//PF14722 Basic region leucine zipper//bZIP transcription factor//Zinc finger, C2H2 type//Ki-ras-induced actin-interacting protein-IP3R-interacting domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0005102//GO:0043565//GO:0046872//GO:0003700 receptor binding//sequence-specific DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.53866 BP_3 228.35 6.06 2109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53867 BP_3 8.09 0.69 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53868 BP_3 15.91 1.48 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53869 BP_3 48.81 1.41 1960 546686197 ERL95577.1 364 7.9e-32 hypothetical protein D910_12838 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.5387 BP_3 6.70 0.51 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53870 BP_3 99.72 1.26 4119 189242026 XP_968092.2 677 8.4e-68 PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938706|ref|XP_008196798.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938708|ref|XP_008196803.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938710|ref|XP_008196809.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938712|ref|XP_008196813.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938715|ref|XP_008196822.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|270015800|gb|EFA12248.1| hypothetical protein TcasGA2_TC016108 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53872 BP_3 12.33 0.38 1854 820805536 AKG92759.1 679 2.2e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 2.83375e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 4.9e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF01586//PF00010 Myogenic Basic domain//Helix-loop-helix DNA-binding domain GO:0006355//GO:0007517 regulation of transcription, DNA-templated//muscle organ development GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.53875 BP_3 25.89 0.70 2081 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53880 BP_3 606.38 63.50 752 189234568 XP_001814929.1 178 1.1e-10 PREDICTED: uncharacterized protein LOC100142616 [Tribolium castaneum]>gi|270002080|gb|EEZ98527.1| hypothetical protein TcasGA2_TC001031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53881 BP_3 91.88 0.41 11091 478255023 ENN75255.1 4817 0.0e+00 hypothetical protein YQE_08171, partial [Dendroctonus ponderosae] -- -- -- -- -- K16681 CRB protein crumbs http://www.genome.jp/dbget-bin/www_bget?ko:K16681 P10040 3268 0.0e+00 Protein crumbs OS=Drosophila melanogaster GN=crb PE=1 SV=3 PF11857//PF07645//PF00008//PF00400//PF04053 Domain of unknown function (DUF3377)//Calcium-binding EGF domain//EGF-like domain//WD domain, G-beta repeat//Coatomer WD associated region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198//GO:0004222//GO:0005509 protein binding//structural molecule activity//metalloendopeptidase activity//calcium ion binding GO:0030117 membrane coat -- -- Cluster-8309.53883 BP_3 13.00 0.48 1610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53884 BP_3 18.00 3.25 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04632 Fusaric acid resistance protein family GO:0006810 transport -- -- GO:0005886 plasma membrane -- -- Cluster-8309.53886 BP_3 452.77 11.42 2202 642933622 XP_008197499.1 2018 1.4e-223 PREDICTED: ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [Tribolium castaneum]>gi|270011314|gb|EFA07762.1| hypothetical protein TcasGA2_TC005316 [Tribolium castaneum] -- -- -- -- -- K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 1264 1.6e-137 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 -- -- GO:0016579//GO:0006511 protein deubiquitination//ubiquitin-dependent protein catabolic process GO:0004221 obsolete ubiquitin thiolesterase activity -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.53888 BP_3 25.76 0.89 1693 270009560 EFA06008.1 162 1.8e-08 hypothetical protein TcasGA2_TC008834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53890 BP_3 204.82 18.79 817 751442604 XP_011195955.1 283 8.1e-23 PREDICTED: uncharacterized protein DDB_G0290301 isoform X1 [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q00690 165 1.6e-10 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53893 BP_3 49.46 5.20 750 642937577 XP_008199105.1 366 1.8e-32 PREDICTED: uncharacterized protein LOC103314533 [Tribolium castaneum]>gi|270001211|gb|EEZ97658.1| hypothetical protein TcasGA2_TC016202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.53894 BP_3 42.65 0.34 6277 642924788 XP_008194040.1 1633 1.8e-178 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 P07663 976 1.1e-103 Period circadian protein OS=Drosophila melanogaster GN=per PE=1 SV=2 PF08926//PF00516//PF08447//PF00989//PF01554 Domain of unknown function (DUF1908)//Envelope glycoprotein GP120//PAS fold//PAS fold//MatE GO:0006855//GO:0016310//GO:0015893//GO:0006355//GO:0006468//GO:0009069//GO:0006810//GO:0055085 drug transmembrane transport//phosphorylation//drug transport//regulation of transcription, DNA-templated//protein phosphorylation//serine family amino acid metabolic process//transport//transmembrane transport GO:0000287//GO:0005515//GO:0015297//GO:0004674//GO:0015238//GO:0005524 magnesium ion binding//protein binding//antiporter activity//protein serine/threonine kinase activity//drug transmembrane transporter activity//ATP binding GO:0016020//GO:0019031 membrane//viral envelope KOG3753 Circadian clock protein period Cluster-8309.53897 BP_3 3.00 0.72 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53900 BP_3 505.00 12.44 2248 642923944 XP_008193936.1 248 2.6e-18 PREDICTED: flexible cuticle protein 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45589 222 1.1e-16 Flexible cuticle protein 12 OS=Hyalophora cecropia GN=CP12 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.53902 BP_3 240.22 13.86 1127 332374552 AEE62417.1 611 1.0e-60 unknown [Dendroctonus ponderosae]>gi|478249849|gb|ENN70356.1| hypothetical protein YQE_12864, partial [Dendroctonus ponderosae] -- -- -- -- -- K15382 SLC50A, SWEET solute carrier family 50 (sugar transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K15382 Q7JVE7 217 2.1e-16 Sugar transporter SWEET1 OS=Drosophila melanogaster GN=slv PE=1 SV=1 PF01040//PF03083 UbiA prenyltransferase family//Sugar efflux transporter for intercellular exchange -- -- GO:0004659 prenyltransferase activity GO:0016021 integral component of membrane KOG1623 Multitransmembrane protein Cluster-8309.53910 BP_3 42.00 0.36 5969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02325 YGGT family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.53914 BP_3 272.81 5.79 2562 765166496 XP_011492062.1 818 2.3e-84 PREDICTED: zinc finger protein 26-like isoform X3 [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 766 1.0e-79 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF00096//PF13912//PF07776//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.53915 BP_3 23.22 0.49 2588 270002772 EEZ99219.1 287 8.8e-23 fruitless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IN81 267 7.6e-22 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53918 BP_3 9.30 0.34 1608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53919 BP_3 21.00 2.07 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53921 BP_3 44.22 1.65 1581 478256576 ENN76758.1 230 2.2e-16 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53922 BP_3 29.65 2.05 990 478256576 ENN76758.1 220 2.0e-15 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53924 BP_3 858.34 8.01 5455 642924788 XP_008194040.1 1633 1.6e-178 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 P07663 976 9.8e-104 Period circadian protein OS=Drosophila melanogaster GN=per PE=1 SV=2 PF00989//PF08447//PF00516//PF08926 PAS fold//PAS fold//Envelope glycoprotein GP120//Domain of unknown function (DUF1908) GO:0006355//GO:0016310//GO:0006468//GO:0009069 regulation of transcription, DNA-templated//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0000287//GO:0005515//GO:0005524 protein serine/threonine kinase activity//magnesium ion binding//protein binding//ATP binding GO:0019031 viral envelope KOG3753 Circadian clock protein period Cluster-8309.53925 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53926 BP_3 92.76 1.65 3002 478263495 ENN81850.1 329 1.4e-27 hypothetical protein YQE_01788, partial [Dendroctonus ponderosae]>gi|546685498|gb|ERL94996.1| hypothetical protein D910_12268 [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9UKD2 259 7.4e-21 mRNA turnover protein 4 homolog OS=Homo sapiens GN=MRTO4 PE=1 SV=2 PF00466//PF00002 Ribosomal protein L10//7 transmembrane receptor (Secretin family) GO:0042254//GO:0007186 ribosome biogenesis//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0005622 integral component of membrane//intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.5393 BP_3 24.00 0.42 3059 270004779 EFA01227.1 430 2.7e-39 hypothetical protein TcasGA2_TC010554 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7P9 267 9.0e-22 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.53930 BP_3 173.50 1.31 6691 642935034 XP_008199914.1 265 8.1e-20 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 271 6.85411e-137 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- Q8IPM8 227 8.5e-17 Complexin OS=Drosophila melanogaster GN=cpx PE=2 SV=1 PF05550//PF02724//PF05835//PF03307//PF10186 Pestivirus Npro endopeptidase C53//CDC45-like protein//Synaphin protein//Adenovirus 15.3kD protein in E3 region//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006836//GO:0016032//GO:0019082//GO:0019049//GO:0006270//GO:0010508 neurotransmitter transport//viral process//viral protein processing//evasion or tolerance of host defenses by virus//DNA replication initiation//positive regulation of autophagy GO:0019905 syntaxin binding -- -- -- -- Cluster-8309.53931 BP_3 121.11 3.23 2100 642935034 XP_008199914.1 150 5.5e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 201 1.74119e-98 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF02841//PF05835//PF04111//PF03938//PF10186 Guanylate-binding protein, C-terminal domain//Synaphin protein//Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508//GO:0006914//GO:0006836 positive regulation of autophagy//autophagy//neurotransmitter transport GO:0019905//GO:0003924//GO:0005525//GO:0051082 syntaxin binding//GTPase activity//GTP binding//unfolded protein binding -- -- -- -- Cluster-8309.53932 BP_3 353.03 5.57 3344 642919403 XP_008191855.1 1871 2.4e-206 PREDICTED: ubiquitin carboxyl-terminal hydrolase 46 [Tribolium castaneum] 642919402 XM_008193633.1 582 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 46 (LOC663037), mRNA K11842 USP12_46 ubiquitin carboxyl-terminal hydrolase 12/46 http://www.genome.jp/dbget-bin/www_bget?ko:K11842 P62068 1430 1.4e-156 Ubiquitin carboxyl-terminal hydrolase 46 OS=Homo sapiens GN=USP46 PE=1 SV=1 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0070140//GO:0032183//GO:0036459 SUMO-specific isopeptidase activity//SUMO binding//ubiquitinyl hydrolase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.53933 BP_3 117.00 9.18 906 270013391 EFA09839.1 1524 1.1e-166 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 820865025 XM_012493602.1 84 8.06345e-34 PREDICTED: Apis florea uncharacterized LOC100872076 (LOC100872076), mRNA -- -- -- -- Q9UM47 208 1.8e-15 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53934 BP_3 64.00 7.59 698 270013391 EFA09839.1 1077 5.9e-115 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34576 159 6.8e-10 Transmembrane cell adhesion receptor mua-3 OS=Caenorhabditis elegans GN=mua-3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53935 BP_3 26.00 2.95 716 270013391 EFA09839.1 1026 5.0e-109 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 95 4.84086e-40 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 202 7.2e-15 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53936 BP_3 237.00 5.45 2386 270013391 EFA09839.1 3741 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 572300552 XM_006616302.1 145 2.67552e-67 PREDICTED: Apis dorsata uncharacterized LOC102671488 (LOC102671488), mRNA -- -- -- -- Q9QW30 335 9.1e-30 Neurogenic locus notch homolog protein 2 OS=Rattus norvegicus GN=Notch2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53941 BP_3 744.03 6.21 6071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53942 BP_3 595.91 13.95 2350 332375488 AEE62885.1 1167 7.3e-125 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02089 CDK4 cyclin-dependent kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02089 Q91727 820 5.2e-86 Cyclin-dependent kinase 4 OS=Xenopus laevis GN=cdk4 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.53944 BP_3 34.12 0.80 2355 332375488 AEE62885.1 1167 7.3e-125 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02089 CDK4 cyclin-dependent kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02089 Q91727 820 5.2e-86 Cyclin-dependent kinase 4 OS=Xenopus laevis GN=cdk4 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.53945 BP_3 20.46 0.41 2705 91091782 XP_969684.1 2706 2.9e-303 PREDICTED: cell division cycle 5-like protein [Tribolium castaneum]>gi|270001087|gb|EEZ97534.1| hypothetical protein TcasGA2_TC011382 [Tribolium castaneum] 807017652 XM_004518985.2 277 1.27049e-140 PREDICTED: Ceratitis capitata cell division cycle 5-like protein (LOC101451004), mRNA K12860 CDC5L, CDC5, CEF1 pre-mRNA-splicing factor CDC5/CEF1 http://www.genome.jp/dbget-bin/www_bget?ko:K12860 O08837 2135 2.0e-238 Cell division cycle 5-like protein OS=Rattus norvegicus GN=Cdc5l PE=1 SV=2 PF07195//PF08912//PF06810//PF08657//PF02096 Flagellar hook-associated protein 2 C-terminus//Rho Binding//Phage minor structural protein GP20//DASH complex subunit Spc34//60Kd inner membrane protein GO:0051205//GO:0007155//GO:0008608 protein insertion into membrane//cell adhesion//attachment of spindle microtubules to kinetochore GO:0005198//GO:0017048//GO:0005488 structural molecule activity//Rho GTPase binding//binding GO:0016021//GO:0005876//GO:0042729//GO:0009288 integral component of membrane//spindle microtubule//DASH complex//bacterial-type flagellum KOG0050 mRNA splicing protein CDC5 (Myb superfamily) Cluster-8309.53946 BP_3 104.45 1.50 3653 91082339 XP_966549.1 5280 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC2 [Tribolium castaneum]>gi|270007487|gb|EFA03935.1| hypothetical protein TcasGA2_TC014075 [Tribolium castaneum] 719740584 XM_010211158.1 114 7.03351e-50 PREDICTED: Tinamus guttatus DNA-directed RNA polymerase III subunit RPC2 (LOC104564515), partial mRNA K03021 RPC2, POLR3B DNA-directed RNA polymerase III subunit RPC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03021 P25167 4223 0.0e+00 DNA-directed RNA polymerase III subunit RPC2 OS=Drosophila melanogaster GN=RpIII128 PE=2 SV=2 PF04565//PF04566//PF00562//PF04563//PF04560//PF04567//PF04561 RNA polymerase Rpb2, domain 3//RNA polymerase Rpb2, domain 4//RNA polymerase Rpb2, domain 6//RNA polymerase beta subunit//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 5//RNA polymerase Rpb2, domain 2 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0032549 DNA-directed RNA polymerase activity//DNA binding//ribonucleoside binding GO:0005730 nucleolus KOG0215 RNA polymerase III, second largest subunit Cluster-8309.53948 BP_3 54.01 7.01 663 91094813 XP_970635.1 956 6.0e-101 PREDICTED: DNA-directed RNA polymerase II subunit RPB3 [Tribolium castaneum]>gi|270006567|gb|EFA03015.1| hypothetical protein TcasGA2_TC010438 [Tribolium castaneum] 751216889 XM_011163108.1 137 2.00501e-63 PREDICTED: Solenopsis invicta DNA-directed RNA polymerase II subunit RPB3 (LOC105196940), mRNA K03011 RPB3, POLR2C DNA-directed RNA polymerase II subunit RPB3 http://www.genome.jp/dbget-bin/www_bget?ko:K03011 P19387 724 2.0e-75 DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens GN=POLR2C PE=1 SV=2 PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0046983 DNA-directed RNA polymerase activity//DNA binding//protein dimerization activity GO:0005730 nucleolus KOG1522 RNA polymerase II, subunit POLR2C/RPB3 Cluster-8309.53949 BP_3 22.00 3.40 604 817087870 XP_012266730.1 223 5.4e-16 PREDICTED: uncharacterized protein LOC105692236 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02421 Ferrous iron transport protein B GO:0015684 ferrous iron transport GO:0005525//GO:0015093 GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.53951 BP_3 5.59 0.42 927 861630394 KMQ90036.1 676 2.5e-68 hypothetical protein RF55_10255, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53952 BP_3 172.96 1.22 7141 546674055 ERL85543.1 387 6.2e-34 hypothetical protein D910_02962 [Dendroctonus ponderosae] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 251 1.5e-19 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF08395//PF07859 7tm Chemosensory receptor//alpha/beta hydrolase fold GO:0008152//GO:0050909 metabolic process//sensory perception of taste GO:0016787 hydrolase activity GO:0016021 integral component of membrane KOG1516 Carboxylesterase and related proteins Cluster-8309.53957 BP_3 63.04 1.46 2372 815765156 XP_012221381.1 913 2.1e-95 PREDICTED: uncharacterized protein LOC105671622 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00412//PF00751//PF00096 LIM domain//DM DNA binding domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0043565 metal ion binding//zinc ion binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.53958 BP_3 491.45 9.63 2752 91092966 XP_966837.1 920 3.7e-96 PREDICTED: phosducin-like protein [Tribolium castaneum]>gi|270003166|gb|EEZ99613.1| hypothetical protein TcasGA2_TC002130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUR7 545 4.7e-54 Phosducin-like protein OS=Drosophila melanogaster GN=CG7650 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3171 Conserved phosducin-like protein Cluster-8309.53959 BP_3 191.49 2.64 3789 642915162 XP_008190500.1 1814 1.1e-199 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02562 152 2.4e-08 Myosin heavy chain, skeletal muscle (Fragments) OS=Oryctolagus cuniculus PE=1 SV=2 PF02135 TAZ zinc finger GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0008270//GO:0003712//GO:0004402 zinc ion binding//transcription cofactor activity//histone acetyltransferase activity GO:0000123//GO:0005634//GO:0005667 histone acetyltransferase complex//nucleus//transcription factor complex -- -- Cluster-8309.53962 BP_3 28.00 2.97 746 410911686 XP_003969321.1 913 6.5e-96 PREDICTED: 40S ribosomal protein S5 [Takifugu rubripes] 697448166 XM_009667215.1 256 1.60034e-129 PREDICTED: Struthio camelus australis ribosomal protein S5 (RPS5), mRNA K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 Q5E988 910 6.0e-97 40S ribosomal protein S5 OS=Bos taurus GN=RPS5 PE=2 SV=3 PF03969 AFG1-like ATPase -- -- GO:0005524 ATP binding -- -- KOG3291 Ribosomal protein S7 Cluster-8309.53963 BP_3 320.06 2.80 5792 270014503 EFA10951.1 4876 0.0e+00 hypothetical protein TcasGA2_TC004111 [Tribolium castaneum] 665818753 XM_008559999.1 137 1.83364e-62 PREDICTED: Microplitis demolitor putative DNA helicase Ino80 (LOC103578813), mRNA K11665 INO80, INOC1 DNA helicase INO80 http://www.genome.jp/dbget-bin/www_bget?ko:K11665 Q9VDY1 3025 0.0e+00 Putative DNA helicase Ino80 OS=Drosophila melanogaster GN=Ino80 PE=1 SV=2 PF00176//PF13892 SNF2 family N-terminal domain//DNA-binding domain -- -- GO:0003677//GO:0005524 DNA binding//ATP binding -- -- KOG0388 SNF2 family DNA-dependent ATPase Cluster-8309.53968 BP_3 93.17 1.60 3091 189235122 XP_001811652.1 2310 2.8e-257 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 473 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1846 7.3e-205 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF15048//PF04277//PF01496//PF00856 Organic solute transporter subunit beta protein//Oxaloacetate decarboxylase, gamma chain//V-type ATPase 116kDa subunit family//SET domain GO:0006560//GO:0015991//GO:0006814//GO:0071436//GO:0006090//GO:0015992//GO:0006525//GO:0006810//GO:0015721 proline metabolic process//ATP hydrolysis coupled proton transport//sodium ion transport//sodium ion export//pyruvate metabolic process//proton transport//arginine metabolic process//transport//bile acid and bile salt transport GO:0015081//GO:0005215//GO:0046982//GO:0005515//GO:0015078//GO:0003682//GO:0008948 sodium ion transmembrane transporter activity//transporter activity//protein heterodimerization activity//protein binding//hydrogen ion transmembrane transporter activity//chromatin binding//oxaloacetate decarboxylase activity GO:0016020//GO:0033179//GO:0000785//GO:0005886 membrane//proton-transporting V-type ATPase, V0 domain//chromatin//plasma membrane KOG1079 Transcriptional repressor EZH1 Cluster-8309.53969 BP_3 5.03 0.56 726 546683481 ERL93287.1 721 1.2e-73 hypothetical protein D910_10583 [Dendroctonus ponderosae] 242012746 XM_002427044.1 86 4.94671e-35 Pediculus humanus corporis enhancer of zeste, ezh, putative, mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 623 1.1e-63 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1079 Transcriptional repressor EZH1 Cluster-8309.5397 BP_3 12.04 0.57 1310 478260022 ENN79811.1 829 6.3e-86 hypothetical protein YQE_03752, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53971 BP_3 292.29 8.37 1974 91088681 XP_974930.1 1028 8.0e-109 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JFV8 482 6.8e-47 Synaptic vesicle membrane protein VAT-1 homolog OS=Danio rerio GN=vat1 PE=2 SV=1 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0005488 binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.53973 BP_3 17.16 0.33 2809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53975 BP_3 1054.61 6.06 8677 642913944 XP_008201224.1 10793 0.0e+00 PREDICTED: leucine-rich repeat serine/threonine-protein kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TZM3 2932 0.0e+00 Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6 PF00071//PF07645//PF00023//PF00025//PF13855//PF13606//PF07714//PF08477//PF00069 Ras family//Calcium-binding EGF domain//Ankyrin repeat//ADP-ribosylation factor family//Leucine rich repeat//Ankyrin repeat//Protein tyrosine kinase//Ras of Complex, Roc, domain of DAPkinase//Protein kinase domain GO:0006468//GO:0007264 protein phosphorylation//small GTPase mediated signal transduction GO:0005509//GO:0005525//GO:0005524//GO:0004672//GO:0005515 calcium ion binding//GTP binding//ATP binding//protein kinase activity//protein binding -- -- -- -- Cluster-8309.53981 BP_3 13.00 0.39 1902 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53982 BP_3 946.51 8.84 5453 642929828 XP_008195992.1 980 8.2e-103 PREDICTED: ephrin-B1 [Tribolium castaneum]>gi|270010986|gb|EFA07434.1| hypothetical protein TcasGA2_TC008794 [Tribolium castaneum] 642929827 XM_008197770.1 229 1.2429e-113 PREDICTED: Tribolium castaneum ephrin-B1 (LOC664511), mRNA K05463 EFNB ephrin-B http://www.genome.jp/dbget-bin/www_bget?ko:K05463 O13097 208 1.1e-14 Ephrin-B1 OS=Xenopus laevis GN=efnb1 PE=1 SV=2 PF00812 Ephrin -- -- -- -- GO:0016020 membrane KOG3858 Ephrin, ligand for Eph receptor tyrosine kinase Cluster-8309.53983 BP_3 614.06 5.57 5610 642929828 XP_008195992.1 980 8.4e-103 PREDICTED: ephrin-B1 [Tribolium castaneum]>gi|270010986|gb|EFA07434.1| hypothetical protein TcasGA2_TC008794 [Tribolium castaneum] 642929827 XM_008197770.1 229 1.27892e-113 PREDICTED: Tribolium castaneum ephrin-B1 (LOC664511), mRNA K05463 EFNB ephrin-B http://www.genome.jp/dbget-bin/www_bget?ko:K05463 O13097 208 1.1e-14 Ephrin-B1 OS=Xenopus laevis GN=efnb1 PE=1 SV=2 PF00812 Ephrin -- -- -- -- GO:0016020 membrane KOG3858 Ephrin, ligand for Eph receptor tyrosine kinase Cluster-8309.53984 BP_3 90.62 0.96 4865 642939444 XP_008200394.1 1205 5.9e-129 PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939446|ref|XP_008200396.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939448|ref|XP_008200397.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939450|ref|XP_008200398.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum] 642939445 XM_008202174.1 38 1.66283e-07 PREDICTED: Tribolium castaneum transcription factor E2F2-like (LOC656396), transcript variant X2, mRNA K06620 E2F3 transcription factor E2F3 http://www.genome.jp/dbget-bin/www_bget?ko:K06620 O00716 437 2.8e-41 Transcription factor E2F3 OS=Homo sapiens GN=E2F3 PE=1 SV=1 PF02319//PF01991 E2F/DP family winged-helix DNA-binding domain//ATP synthase (E/31 kDa) subunit GO:0015991//GO:0006119//GO:0006355//GO:0015992 ATP hydrolysis coupled proton transport//oxidative phosphorylation//regulation of transcription, DNA-templated//proton transport GO:0046961//GO:0003700 proton-transporting ATPase activity, rotational mechanism//transcription factor activity, sequence-specific DNA binding GO:0033178//GO:0005667 proton-transporting two-sector ATPase complex, catalytic domain//transcription factor complex KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.53985 BP_3 29.84 0.42 3708 91091628 XP_970031.1 1001 2.0e-105 PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial [Tribolium castaneum] 780117224 XM_775688.3 40 9.77462e-09 PREDICTED: Strongylocentrotus purpuratus cathepsin L1 (LOC575275), mRNA K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 881 6.9e-93 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF04139//PF15163//PF02144//PF01180//PF03051//PF00112 Rad9//Meiosis-expressed//Repair protein Rad1/Rec1/Rad17//Dihydroorotate dehydrogenase//Peptidase C1-like family//Papain family cysteine protease GO:0000077//GO:0006508//GO:0055114//GO:0006281 DNA damage checkpoint//proteolysis//oxidation-reduction process//DNA repair GO:0008234//GO:0004197//GO:0016627 cysteine-type peptidase activity//cysteine-type endopeptidase activity//oxidoreductase activity, acting on the CH-CH group of donors GO:0005737//GO:0005634//GO:0030896 cytoplasm//nucleus//checkpoint clamp complex KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.53987 BP_3 3.02 0.48 597 86515378 NP_001034514.1 220 1.2e-15 laccase 1 [Tribolium castaneum]>gi|642912767|ref|XP_008201239.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|642912769|ref|XP_008201241.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|642912771|ref|XP_008201242.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|68137818|gb|AAX84206.1| laccase 1 [Tribolium castaneum]>gi|270001917|gb|EEZ98364.1| hypothetical protein TcasGA2_TC000821 [Tribolium castaneum] 689934885 LM419285.1 34 3.24608e-06 Enterobius vermicularis genome assembly E_vermicularis_Canary_Islands ,scaffold EVEC_scaffold0005575 -- -- -- -- -- -- -- -- PF11575 FhuF 2Fe-2S C-terminal domain GO:0055114 oxidation-reduction process GO:0005507//GO:0051537//GO:0016491 copper ion binding//2 iron, 2 sulfur cluster binding//oxidoreductase activity -- -- -- -- Cluster-8309.53991 BP_3 307.73 41.98 645 270000727 EEZ97174.1 449 3.6e-42 hypothetical protein TcasGA2_TC004361 [Tribolium castaneum] 752865554 XM_011270924.1 89 9.38774e-37 PREDICTED: Camponotus floridanus RNA-binding protein 1-like (LOC105259161), transcript variant X11, mRNA K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q02427 409 6.5e-39 RNA-binding protein 1 OS=Drosophila melanogaster GN=Rbp1 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily) Cluster-8309.53992 BP_3 4.09 0.34 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53994 BP_3 705.00 6.74 5330 91089913 XP_972686.1 1426 1.5e-154 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933954|ref|XP_008197580.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933957|ref|XP_008197581.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013662|gb|EFA10110.1| hypothetical protein TcasGA2_TC012289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0WC46 506 3.0e-49 Facilitated trehalose transporter Tret1 OS=Culex quinquefasciatus GN=Tret1 PE=3 SV=1 PF01306//PF00083//PF07690 LacY proton/sugar symporter//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.53995 BP_3 16.00 0.45 2010 270007175 EFA03623.1 1786 1.0e-196 hypothetical protein TcasGA2_TC013716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.540 BP_3 3.00 0.66 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5400 BP_3 6.00 0.35 1128 646634636 KDQ71520.1 672 8.7e-68 Adenosine receptor A2b [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P29276 216 2.7e-16 Adenosine receptor A2b OS=Rattus norvegicus GN=Adora2b PE=1 SV=1 PF01690//PF00001 Potato leaf roll virus readthrough protein//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.54002 BP_3 14.01 0.47 1721 478258622 ENN78672.1 343 1.9e-29 hypothetical protein YQE_04844, partial [Dendroctonus ponderosae]>gi|546685778|gb|ERL95227.1| hypothetical protein D910_12494 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q502E5 173 4.0e-11 Small integral membrane protein 8 OS=Danio rerio GN=smim8 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54004 BP_3 32.00 0.60 2874 270015894 EFA12342.1 2055 9.6e-228 hypothetical protein TcasGA2_TC001856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF03175//PF00096//PF00701 C2H2-type zinc finger//DNA polymerase type B, organellar and viral//Zinc finger, C2H2 type//Dihydrodipicolinate synthetase family GO:0006260//GO:0008152 DNA replication//metabolic process GO:0000166//GO:0008408//GO:0046872//GO:0016829//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//metal ion binding//lyase activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.54007 BP_3 4.00 2.96 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54009 BP_3 143.00 3.76 2123 189234079 XP_001810604.1 738 3.7e-75 PREDICTED: pleckstrin homology domain-containing family J member 1 [Tribolium castaneum]>gi|270014493|gb|EFA10941.1| hypothetical protein TcasGA2_TC001772 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZCI3 239 1.1e-18 Pleckstrin homology domain-containing family J member 1 OS=Bos taurus GN=PLEKHJ1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54010 BP_3 453.14 3.68 6233 642929348 XP_008195797.1 4169 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1646 2.3e-181 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF00498//PF00787//PF00225//PF08352//PF09111//PF02601 FHA domain//PX domain//Kinesin motor domain//Oligopeptide/dipeptide transporter, C-terminal region//SLIDE//Exonuclease VII, large subunit GO:0006308//GO:0015833//GO:0007017//GO:0007018//GO:0006338 DNA catabolic process//peptide transport//microtubule-based process//microtubule-based movement//chromatin remodeling GO:0003676//GO:0008017//GO:0005515//GO:0003777//GO:0008855//GO:0000166//GO:0016818//GO:0005524//GO:0035091 nucleic acid binding//microtubule binding//protein binding//microtubule motor activity//exodeoxyribonuclease VII activity//nucleotide binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//phosphatidylinositol binding GO:0005634//GO:0005874//GO:0009318//GO:0045298 nucleus//microtubule//exodeoxyribonuclease VII complex//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.54011 BP_3 113.00 1.35 4325 270004778 EFA01226.1 1108 9.3e-118 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 854 1.1e-89 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF16588//PF00558//PF00098 C2H2 zinc-finger//Vpu protein//Zinc knuckle GO:0032801//GO:0019076//GO:0006812 receptor catabolic process//viral release from host cell//cation transport GO:0005261//GO:0008270//GO:0003676 cation channel activity//zinc ion binding//nucleic acid binding GO:0033644 host cell membrane KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.54012 BP_3 28.00 0.94 1721 270017072 EFA13518.1 639 9.0e-64 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10394 466 4.2e-45 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54013 BP_3 283.00 6.50 2389 642939002 XP_008200112.1 644 3.3e-64 PREDICTED: uncharacterized protein LOC103314838 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54015 BP_3 1.00 3.49 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54017 BP_3 7.14 0.43 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54018 BP_3 5.00 1.02 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54020 BP_3 231.37 7.78 1726 91085575 XP_968070.1 1854 1.2e-204 PREDICTED: glutathione synthetase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K01920 gshB, GSS glutathione synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01920 P46413 996 1.5e-106 Glutathione synthetase OS=Rattus norvegicus GN=Gss PE=1 SV=1 PF03917//PF03199 Eukaryotic glutathione synthase, ATP binding domain//Eukaryotic glutathione synthase GO:0006750 glutathione biosynthetic process GO:0005524//GO:0004363 ATP binding//glutathione synthase activity -- -- KOG0021 Glutathione synthetase Cluster-8309.54022 BP_3 10.35 0.78 933 91078046 XP_971013.1 321 3.6e-27 PREDICTED: protein inscuteable homolog [Tribolium castaneum]>gi|270002309|gb|EEZ98756.1| hypothetical protein TcasGA2_TC001320 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3HNM7 129 2.7e-06 Protein inscuteable homolog OS=Mus musculus GN=Insc PE=1 SV=2 PF00514 Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54029 BP_3 712.91 15.35 2530 642939677 XP_008192358.1 254 5.8e-19 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103312719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF02892 Zinc finger, C2H2 type//BED zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.54031 BP_3 2.00 0.47 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54032 BP_3 9.58 0.47 1275 675376181 KFM69083.1 205 1.4e-13 hypothetical protein X975_14697, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54035 BP_3 141.75 2.82 2716 328705425 XP_003242798.1 231 2.9e-16 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54036 BP_3 10.00 2.67 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54038 BP_3 159.74 3.24 2668 270015371 EFA11819.1 231 2.8e-16 hypothetical protein TcasGA2_TC016421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54040 BP_3 178.47 3.66 2643 642939677 XP_008192358.1 240 2.5e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103312719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF13465//PF00096//PF05320 BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.54041 BP_3 5.00 0.97 540 546687063 ERL95973.1 181 3.6e-11 hypothetical protein D910_00717 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06109 Haemolysin E (HlyE) GO:0044179//GO:0009405 hemolysis in other organism//pathogenesis -- -- -- -- -- -- Cluster-8309.54043 BP_3 44.52 0.37 6093 270004778 EFA01226.1 1478 1.6e-160 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1060 2.0e-113 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF16867//PF00665//PF13683 Dimethlysulfonioproprionate lyase//Integrase core domain//Integrase core domain GO:0015074 DNA integration GO:0047869 dimethylpropiothetin dethiomethylase activity -- -- -- -- Cluster-8309.54044 BP_3 103.72 2.30 2469 189235509 XP_969871.2 1939 2.3e-214 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 721 1.6e-74 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3621 WD40 repeat-containing protein Cluster-8309.54045 BP_3 7.60 0.60 900 642938015 XP_008199171.1 409 2.2e-37 PREDICTED: uncharacterized protein LOC659947 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601//PF04140//PF00974 Coronavirus S2 glycoprotein//Isoprenylcysteine carboxyl methyltransferase (ICMT) family//Rhabdovirus spike glycoprotein GO:0061025//GO:0006479//GO:0006481//GO:0046813 membrane fusion//protein methylation//C-terminal protein methylation//receptor-mediated virion attachment to host cell GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021//GO:0019031 integral component of membrane//viral envelope -- -- Cluster-8309.54047 BP_3 8.24 0.34 1464 642917791 XP_008191288.1 445 2.4e-41 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X2 [Tribolium castaneum] 403179775 XM_003338024.2 42 2.94152e-10 Puccinia graminis f. sp. tritici CRL 75-36-700-3 glucosamine-fructose-6-phosphate aminotransferase (PGTG_19602), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 P47856 338 2.5e-30 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Mus musculus GN=Gfpt1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.54048 BP_3 1357.76 90.99 1011 642930259 XP_008196320.1 587 5.6e-58 PREDICTED: uncharacterized protein LOC103313831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.5405 BP_3 6.00 1.18 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54050 BP_3 58.83 1.16 2726 260799997 XP_002594923.1 439 2.2e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- O62836 323 2.6e-28 Zinc finger X-chromosomal protein OS=Bos taurus GN=ZFX PE=2 SV=2 PF02150//PF13465//PF00096//PF07649 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0047134//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//protein-disulfide reductase activity//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.54053 BP_3 408.03 10.48 2168 91090216 XP_968004.1 1600 4.2e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.4e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008476//GO:0008146 protein-tyrosine sulfotransferase activity//sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.54054 BP_3 12.64 0.79 1065 642940144 XP_008200104.1 770 3.6e-79 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9L7 341 8.2e-31 Vacuolar protein sorting-associated protein 16 homolog OS=Bos taurus GN=VPS16 PE=2 SV=1 PF04840 Vps16, C-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.54055 BP_3 171.40 2.41 3720 642926488 XP_008191976.1 3620 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase kurz [Tribolium castaneum]>gi|270009095|gb|EFA05543.1| hypothetical protein TcasGA2_TC015731 [Tribolium castaneum] -- -- -- -- -- K14780 DHX37, DHR1 ATP-dependent RNA helicase DHX37/DHR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14780 O46072 2617 3.5e-294 Probable ATP-dependent RNA helicase kurz OS=Drosophila melanogaster GN=kz PE=1 SV=1 PF04408//PF07652//PF00437//PF00270//PF01580 Helicase associated domain (HA2)//Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase//FtsK/SpoIIIE family GO:0006810//GO:0019079 transport//viral genome replication GO:0008026//GO:0004386//GO:0005524//GO:0003677//GO:0000166//GO:0003676 ATP-dependent helicase activity//helicase activity//ATP binding//DNA binding//nucleotide binding//nucleic acid binding -- -- KOG0926 DEAH-box RNA helicase Cluster-8309.54058 BP_3 270.97 11.46 1431 270016600 EFA13046.1 217 6.4e-15 hypothetical protein TcasGA2_TC010748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54059 BP_3 54.51 0.52 5375 270011137 EFA07585.1 331 1.5e-27 ion transport peptide [Tribolium castaneum] 751224970 XM_011167549.1 76 1.38155e-28 PREDICTED: Solenopsis invicta ion transport peptide-like (LOC105200138), transcript variant X3, mRNA -- -- -- -- Q26491 257 2.3e-20 Ion transport peptide OS=Schistocerca gregaria PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54064 BP_3 15758.81 920.39 1117 642928075 XP_008200145.1 322 3.3e-27 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270010867|gb|EFA07315.1| hypothetical protein TcasGA2_TC015908 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 267 3.3e-22 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.54065 BP_3 5.37 0.35 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54067 BP_3 184.82 4.92 2103 189238819 XP_967914.2 2083 4.0e-231 PREDICTED: N6-adenosine-methyltransferase 70 kDa subunit [Tribolium castaneum]>gi|270009967|gb|EFA06415.1| hypothetical protein TcasGA2_TC009294 [Tribolium castaneum] 719791100 XM_010225608.1 200 6.27154e-98 PREDICTED: Tinamus guttatus methyltransferase like 3 (METTL3), partial mRNA K05925 METTL3_14 mRNA (2'-O-methyladenosine-N6-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05925 Q86U44 1439 7.7e-158 N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 PF05063//PF07700//PF03121 MT-A70//Haem-NO-binding//Herpesviridae UL52/UL70 DNA primase GO:0006396//GO:0009451//GO:0006269//GO:0006260//GO:0006139//GO:0001510//GO:0006351 RNA processing//RNA modification//DNA replication, synthesis of RNA primer//DNA replication//nucleobase-containing compound metabolic process//RNA methylation//transcription, DNA-templated GO:0020037//GO:0008168//GO:0003896//GO:0016422 heme binding//methyltransferase activity//DNA primase activity//mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity GO:0005730//GO:0005657//GO:0005634 nucleolus//replication fork//nucleus KOG2098 Predicted N6-adenine RNA methylase Cluster-8309.54068 BP_3 61.18 1.77 1957 189238819 XP_967914.2 2069 1.5e-229 PREDICTED: N6-adenosine-methyltransferase 70 kDa subunit [Tribolium castaneum]>gi|270009967|gb|EFA06415.1| hypothetical protein TcasGA2_TC009294 [Tribolium castaneum] 719791100 XM_010225608.1 200 5.82877e-98 PREDICTED: Tinamus guttatus methyltransferase like 3 (METTL3), partial mRNA K05925 METTL3_14 mRNA (2'-O-methyladenosine-N6-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05925 Q86U44 1439 7.2e-158 N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 PF03121//PF07700//PF05063 Herpesviridae UL52/UL70 DNA primase//Haem-NO-binding//MT-A70 GO:0006260//GO:0006269//GO:0009451//GO:0006396//GO:0001510//GO:0006351//GO:0006139 DNA replication//DNA replication, synthesis of RNA primer//RNA modification//RNA processing//RNA methylation//transcription, DNA-templated//nucleobase-containing compound metabolic process GO:0008168//GO:0020037//GO:0003896//GO:0016422 methyltransferase activity//heme binding//DNA primase activity//mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity GO:0005730//GO:0005657//GO:0005634 nucleolus//replication fork//nucleus KOG2098 Predicted N6-adenine RNA methylase Cluster-8309.54074 BP_3 4.97 2.29 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54075 BP_3 27.00 1.02 1565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54076 BP_3 243.84 6.87 2002 546683411 ERL93227.1 1986 6.7e-220 hypothetical protein D910_10523 [Dendroctonus ponderosae] 830067296 XM_004687410.2 167 1.31895e-79 PREDICTED: Condylura cristata serine/threonine kinase 4 (STK4), mRNA K04412 STK3, MST2 serine/threonine kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04412 Q7ZUQ3 1336 6.5e-146 Serine/threonine-protein kinase 3 OS=Danio rerio GN=stk3 PE=2 SV=1 PF00069//PF07714//PF11629 Protein kinase domain//Protein tyrosine kinase//C terminal SARAH domain of Mst1 GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0574 STE20-like serine/threonine kinase MST Cluster-8309.54078 BP_3 42.31 0.63 3537 91094511 XP_971832.1 439 2.9e-40 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.57288e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 Q8VHV7 270 4.6e-22 Heterogeneous nuclear ribonucleoprotein H OS=Rattus norvegicus GN=Hnrnph1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.54080 BP_3 215.64 3.64 3145 91077592 XP_973319.1 1655 2.5e-181 PREDICTED: decaprenyl-diphosphate synthase subunit 1 [Tribolium castaneum] 645030079 XM_008211983.1 197 4.38529e-96 PREDICTED: Nasonia vitripennis decaprenyl-diphosphate synthase subunit 1 (LOC100118369), transcript variant X4, mRNA K12504 PDSS1 decaprenyl-diphosphate synthase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12504 Q5T2R2 916 5.1e-97 Decaprenyl-diphosphate synthase subunit 1 OS=Homo sapiens GN=PDSS1 PE=1 SV=1 PF00217//PF00348 ATP:guanido phosphotransferase, C-terminal catalytic domain//Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.54081 BP_3 1572.92 18.18 4461 270008889 EFA05337.1 1352 4.9e-146 hypothetical protein TcasGA2_TC015501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MKK4 678 2.9e-69 Facilitated trehalose transporter Tret1-2 homolog OS=Drosophila melanogaster GN=Tret1-2 PE=2 SV=1 PF10483//PF00083//PF08029//PF07690//PF05493//PF02487 Elongator subunit Iki1//Sugar (and other) transporter//HisG, C-terminal domain//Major Facilitator Superfamily//ATP synthase subunit H//CLN3 protein GO:0055085//GO:0015991//GO:0006547//GO:0000105//GO:0015992 transmembrane transport//ATP hydrolysis coupled proton transport//histidine metabolic process//histidine biosynthetic process//proton transport GO:0022857//GO:0003879//GO:0015078//GO:0000287 transmembrane transporter activity//ATP phosphoribosyltransferase activity//hydrogen ion transmembrane transporter activity//magnesium ion binding GO:0016021//GO:0016020//GO:0033179//GO:0005737//GO:0033588 integral component of membrane//membrane//proton-transporting V-type ATPase, V0 domain//cytoplasm//Elongator holoenzyme complex KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.54082 BP_3 365.38 4.23 4455 270008889 EFA05337.1 1352 4.9e-146 hypothetical protein TcasGA2_TC015501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MKK4 678 2.9e-69 Facilitated trehalose transporter Tret1-2 homolog OS=Drosophila melanogaster GN=Tret1-2 PE=2 SV=1 PF02487//PF00083//PF10483//PF08029//PF05493//PF07690 CLN3 protein//Sugar (and other) transporter//Elongator subunit Iki1//HisG, C-terminal domain//ATP synthase subunit H//Major Facilitator Superfamily GO:0000105//GO:0015992//GO:0006547//GO:0015991//GO:0055085 histidine biosynthetic process//proton transport//histidine metabolic process//ATP hydrolysis coupled proton transport//transmembrane transport GO:0000287//GO:0003879//GO:0015078//GO:0022857 magnesium ion binding//ATP phosphoribosyltransferase activity//hydrogen ion transmembrane transporter activity//transmembrane transporter activity GO:0033179//GO:0005737//GO:0033588//GO:0016020//GO:0016021 proton-transporting V-type ATPase, V0 domain//cytoplasm//Elongator holoenzyme complex//membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.54083 BP_3 41.62 0.42 5121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54084 BP_3 13.40 0.40 1907 642912175 XP_008200838.1 822 6.0e-85 PREDICTED: heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog isoform X2 [Tribolium castaneum] 780671672 XM_011697100.1 128 6.00771e-58 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 1.2e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00313//PF00076//PF16367 'Cold-shock' DNA-binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.54087 BP_3 742.69 18.10 2270 642937299 XP_008198776.1 862 1.6e-89 PREDICTED: DNA excision repair protein ERCC-1 [Tribolium castaneum] -- -- -- -- -- K10849 ERCC1 DNA excision repair protein ERCC-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10849 P07992 621 5.9e-63 DNA excision repair protein ERCC-1 OS=Homo sapiens GN=ERCC1 PE=1 SV=1 PF01367//PF00633//PF01296//PF10391//PF07690 5'-3' exonuclease, C-terminal SAM fold//Helix-hairpin-helix motif//Galanin//Fingers domain of DNA polymerase lambda//Major Facilitator Superfamily GO:0007165//GO:0055085 signal transduction//transmembrane transport GO:0003824//GO:0003677//GO:0005179//GO:0034061 catalytic activity//DNA binding//hormone activity//DNA polymerase activity GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG2841 Structure-specific endonuclease ERCC1-XPF, ERCC1 component Cluster-8309.54089 BP_3 7.00 0.55 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54090 BP_3 23.08 0.68 1918 642925139 XP_001813550.2 389 9.7e-35 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42282 208 3.9e-15 Protein tramtrack, alpha isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=3 PF00096//PF13465//PF00651//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//BTB/POZ domain//BED zinc finger//C2H2-type zinc finger -- -- GO:0003677//GO:0005515//GO:0046872 DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.54093 BP_3 8.06 0.66 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54097 BP_3 1.00 13.75 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54098 BP_3 105.41 3.80 1630 328705425 XP_003242798.1 264 2.6e-20 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF13639//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Ring finger domain//BED zinc finger -- -- GO:0008270//GO:0003677//GO:0005515//GO:0046872 zinc ion binding//DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.54099 BP_3 39.70 2.19 1166 328705425 XP_003242798.1 264 1.8e-20 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF13639//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//Ring finger domain//BED zinc finger -- -- GO:0003677//GO:0008270//GO:0005515//GO:0046872 DNA binding//zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.54101 BP_3 632.00 16.93 2091 91091144 XP_970545.1 1198 1.6e-128 PREDICTED: uncharacterized protein LOC659120 [Tribolium castaneum]>gi|270014092|gb|EFA10540.1| hypothetical protein TcasGA2_TC012795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.54103 BP_3 170.00 2.96 3060 642932510 XP_008197143.1 2229 6.8e-248 PREDICTED: chromosome transmission fidelity protein 18 homolog [Tribolium castaneum] -- -- -- -- -- K11269 CTF18, CHL12 chromosome transmission fidelity protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K11269 Q6NU40 1245 3.5e-135 Chromosome transmission fidelity protein 18 homolog OS=Xenopus laevis GN=chtf18 PE=2 SV=1 PF00004//PF07724//PF01695//PF07728//PF05496//PF08519//PF00910//PF00931//PF00005//PF03266//PF03193//PF06414 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Replication factor RFC1 C terminal domain//RNA helicase//NB-ARC domain//ABC transporter//NTPase//Protein of unknown function, DUF258//Zeta toxin GO:0006310//GO:0006260//GO:0006281 DNA recombination//DNA replication//DNA repair GO:0005525//GO:0003724//GO:0009378//GO:0003723//GO:0043531//GO:0003689//GO:0016887//GO:0016301//GO:0005524//GO:0098519//GO:0003924 GTP binding//RNA helicase activity//four-way junction helicase activity//RNA binding//ADP binding//DNA clamp loader activity//ATPase activity//kinase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//GTPase activity GO:0005657//GO:0009379//GO:0005663//GO:0042575 replication fork//Holliday junction helicase complex//DNA replication factor C complex//DNA polymerase complex KOG1969 DNA replication checkpoint protein CHL12/CTF18 Cluster-8309.54106 BP_3 254.55 5.02 2738 91092966 XP_966837.1 920 3.7e-96 PREDICTED: phosducin-like protein [Tribolium castaneum]>gi|270003166|gb|EEZ99613.1| hypothetical protein TcasGA2_TC002130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUR7 545 4.7e-54 Phosducin-like protein OS=Drosophila melanogaster GN=CG7650 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3171 Conserved phosducin-like protein Cluster-8309.54107 BP_3 423.48 5.95 3724 642932262 XP_008197037.1 3943 0.0e+00 PREDICTED: exosome complex exonuclease RRP44 [Tribolium castaneum]>gi|270012315|gb|EFA08763.1| hypothetical protein TcasGA2_TC006450 [Tribolium castaneum] 642932261 XM_008198815.1 549 0 PREDICTED: Tribolium castaneum exosome complex exonuclease RRP44 (LOC655788), mRNA K12585 DIS3, RRP44 exosome complex exonuclease DIS3/RRP44 http://www.genome.jp/dbget-bin/www_bget?ko:K12585 Q9Y2L1 2571 7.5e-289 Exosome complex exonuclease RRP44 OS=Homo sapiens GN=DIS3 PE=1 SV=2 -- -- GO:0051252 regulation of RNA metabolic process GO:0004540//GO:0003723 ribonuclease activity//RNA binding -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-8309.54109 BP_3 5.00 0.57 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54113 BP_3 1.00 1.06 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54114 BP_3 267.99 8.60 1794 642914168 XP_972661.2 528 6.9e-51 PREDICTED: crossover junction endonuclease EME1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10882 EME1, MMS4 crossover junction endonuclease EME1 http://www.genome.jp/dbget-bin/www_bget?ko:K10882 Q96AY2 224 5.1e-17 Crossover junction endonuclease EME1 OS=Homo sapiens GN=EME1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54115 BP_3 32.06 0.51 3313 861616833 KMQ86423.1 1250 2.4e-134 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 498 1.6e-48 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00328//PF01165 Histidine phosphatase superfamily (branch 2)//Ribosomal protein S21 GO:0042254//GO:0006412//GO:0019497//GO:0006771 ribosome biogenesis//translation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003735//GO:0003993 structural constituent of ribosome//acid phosphatase activity GO:0005840 ribosome KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.54116 BP_3 639.21 12.20 2818 642910982 XP_008193494.1 1168 6.7e-125 PREDICTED: uncharacterized protein LOC662081 isoform X1 [Tribolium castaneum] 642910981 XM_008195272.1 151 1.46216e-70 PREDICTED: Tribolium castaneum uncharacterized LOC662081 (LOC662081), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF01607//PF15221 Chitin binding Peritrophin-A domain//Lens epithelial cell protein LEP503 GO:0006030//GO:0007275 chitin metabolic process//multicellular organismal development GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.54117 BP_3 21.93 0.41 2872 270016838 EFA13284.1 164 1.8e-08 hypothetical protein TcasGA2_TC010304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5412 BP_3 4.00 0.45 720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54123 BP_3 59.68 0.78 3986 546678752 ERL89304.1 189 3.1e-11 hypothetical protein D910_06676, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54125 BP_3 55.89 0.92 3226 642920491 XP_008192374.1 1484 1.7e-161 PREDICTED: acyl-CoA synthetase family member 4 homolog [Tribolium castaneum] -- -- -- -- -- K00142 AASDH acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00142 Q4L235 588 5.7e-59 Acyl-CoA synthetase family member 4 OS=Homo sapiens GN=AASDH PE=1 SV=3 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.54126 BP_3 115.29 4.03 1671 766936334 XP_011500571.1 1518 1.0e-165 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 [Ceratosolen solmsi marchali] 820866238 XM_012494102.1 302 9.86551e-155 PREDICTED: Apis florea mitogen-activated protein kinase kinase kinase kinase 5 (LOC100864577), transcript variant X9, mRNA K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q8IVH8 1293 5.2e-141 Mitogen-activated protein kinase kinase kinase kinase 3 OS=Homo sapiens GN=MAP4K3 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.54134 BP_3 35.62 0.39 4699 817074162 XP_012259260.1 369 5.0e-32 PREDICTED: uncharacterized protein LOC105687895 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54135 BP_3 88.40 1.00 4551 91079410 XP_967066.1 1140 1.9e-121 PREDICTED: nudC domain-containing protein 1 [Tribolium castaneum]>gi|270003473|gb|EEZ99920.1| hypothetical protein TcasGA2_TC002712 [Tribolium castaneum] -- -- -- -- -- K07071 K07071 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K07071 Q6PIP5 579 8.8e-58 NudC domain-containing protein 1 OS=Mus musculus GN=Nudcd1 PE=2 SV=2 PF07650//PF00070//PF00705//PF03184//PF01370 KH domain//Pyridine nucleotide-disulphide oxidoreductase//Proliferating cell nuclear antigen, N-terminal domain//DDE superfamily endonuclease//NAD dependent epimerase/dehydratase family GO:0006275//GO:0055114 regulation of DNA replication//oxidation-reduction process GO:0003677//GO:0003723//GO:0050662//GO:0003824//GO:0016491//GO:0003676 DNA binding//RNA binding//coenzyme binding//catalytic activity//oxidoreductase activity//nucleic acid binding -- -- KOG4379 Uncharacterized conserved protein (tumor antigen CML66 in humans) Cluster-8309.54136 BP_3 20.34 0.59 1944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54144 BP_3 57.60 4.03 980 357605860 EHJ64807.1 370 7.9e-33 translation initiation factor 1a [Danaus plexippus] -- -- -- -- -- K15025 EIF1AD probable RNA-binding protein EIF1AD http://www.genome.jp/dbget-bin/www_bget?ko:K15025 Q8IQ13 306 8.6e-27 Probable RNA-binding protein EIF1AD OS=Drosophila melanogaster GN=CG31957 PE=2 SV=1 PF01176 Translation initiation factor 1A / IF-1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.54148 BP_3 85.00 1.94 2405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54149 BP_3 4.00 73.37 228 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54150 BP_3 1410.00 37.79 2090 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54152 BP_3 89.64 0.96 4808 641658099 XP_008180596.1 1075 6.9e-114 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 967 9.5e-103 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF00096//PF13465//PF00400//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//WD domain, G-beta repeat//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.54154 BP_3 17.83 2.45 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54155 BP_3 21.23 2.14 769 546679670 ERL90097.1 447 7.3e-42 hypothetical protein D910_07451 [Dendroctonus ponderosae] 158285680 XM_001687879.1 55 8.98055e-18 Anopheles gambiae str. PEST AGAP007421-PA (AgaP_AGAP007421) mRNA, complete cds K18334 fucD L-fuconate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K18334 Q5RAT4 267 2.2e-22 Mitochondrial enolase superfamily member 1 OS=Pongo abelii GN=ENOSF1 PE=2 SV=1 PF04421 Mss4 protein GO:0007264//GO:0043087 small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.54157 BP_3 53.65 1.22 2419 242018392 XP_002429661.1 645 2.5e-64 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 529 2.9e-52 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.54158 BP_3 226.00 5.55 2253 642913102 XP_008201393.1 1765 3.2e-194 PREDICTED: PCI domain-containing protein 2 [Tribolium castaneum]>gi|642913104|ref|XP_001816040.2| PREDICTED: PCI domain-containing protein 2 [Tribolium castaneum]>gi|270001938|gb|EEZ98385.1| hypothetical protein TcasGA2_TC000849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BFV2 1195 1.6e-129 PCI domain-containing protein 2 OS=Mus musculus GN=Pcid2 PE=2 SV=1 PF01399 PCI domain -- -- GO:0005515 protein binding -- -- KOG2688 Transcription-associated recombination protein - Thp1p Cluster-8309.54163 BP_3 42.07 0.76 2946 270016838 EFA13284.1 164 1.8e-08 hypothetical protein TcasGA2_TC010304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54166 BP_3 14.00 0.56 1503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54168 BP_3 33.65 0.31 5450 345794359 XP_544444.3 208 2.7e-13 PREDICTED: LOW QUALITY PROTEIN: collagen alpha-1(XVI) chain [Canis lupus familiaris] 808128522 XM_012311748.1 77 3.89519e-29 PREDICTED: Bombus terrestris uncharacterized LOC105666046 (LOC105666046), mRNA K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 Q07092 197 2.1e-13 Collagen alpha-1(XVI) chain OS=Homo sapiens GN=COL16A1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.5417 BP_3 3.00 0.37 687 669220923 CDW57771.1 136 7.6e-06 zinc finger protein [Trichuris trichiura] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54170 BP_3 7.03 0.32 1353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54171 BP_3 23.76 0.41 3089 642931322 XP_008196531.1 2334 4.6e-260 PREDICTED: kinase suppressor of Ras 2 isoform X2 [Tribolium castaneum] 642931321 XM_008198309.1 207 1.18887e-101 PREDICTED: Tribolium castaneum kinase suppressor of Ras 2 (LOC661985), transcript variant X2, mRNA K18529 KSR2 kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18529 Q3UVC0 350 2.1e-31 Kinase suppressor of Ras 2 OS=Mus musculus GN=Ksr2 PE=2 SV=2 PF06293//PF00069//PF07714//PF07649//PF00130 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006468//GO:0035556//GO:0055114 protein phosphorylation//intracellular signal transduction//oxidation-reduction process GO:0005524//GO:0016773//GO:0004672//GO:0047134 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein-disulfide reductase activity GO:0016020 membrane KOG0193 Serine/threonine protein kinase RAF Cluster-8309.54172 BP_3 458.00 6.24 3832 642919536 XP_008191915.1 155 2.6e-07 PREDICTED: uncharacterized protein LOC103312626 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54173 BP_3 29.01 0.50 3110 91078286 XP_971953.1 766 3.0e-78 PREDICTED: negative elongation factor E [Tribolium castaneum]>gi|270003949|gb|EFA00397.1| hypothetical protein TcasGA2_TC003247 [Tribolium castaneum] -- -- -- -- -- K15182 RDBP, NELFE negative elongation factor E http://www.genome.jp/dbget-bin/www_bget?ko:K15182 P92204 428 2.0e-40 Negative elongation factor E OS=Drosophila melanogaster GN=Nelf-E PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- -- -- Cluster-8309.54178 BP_3 91.75 1.21 3937 642923667 XP_008193834.1 3103 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] 170052083 XM_001862026.1 43 2.23194e-10 Culex quinquefasciatus multidrug resistance-associated protein 14, mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2045 7.8e-228 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF03193//PF01416//PF00005//PF02367//PF01926//PF13304//PF00664 Protein of unknown function, DUF258//tRNA pseudouridine synthase//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810//GO:0009451//GO:0002949//GO:0001522 transmembrane transport//transport//RNA modification//tRNA threonylcarbamoyladenosine modification//pseudouridine synthesis GO:0005524//GO:0003723//GO:0003924//GO:0016887//GO:0009982//GO:0005525//GO:0042626 ATP binding//RNA binding//GTPase activity//ATPase activity//pseudouridine synthase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.5418 BP_3 25.75 0.59 2399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54180 BP_3 1613.00 8.64 9292 219522040 NP_001137201.1 1569 7.0e-171 mex-3 protein [Tribolium castaneum]>gi|218464687|emb|CAM28380.2| KH domain protein [Tribolium castaneum] 219522039 NM_001143729.1 449 0 Tribolium castaneum mex-3 protein (Mex-3), mRNA >gnl|BL_ORD_ID|6206389 Tribolium castaneum mRNA for KH domain protein (mex-3 gene) K15686 MEX3, RKHD RNA-binding protein MEX3 http://www.genome.jp/dbget-bin/www_bget?ko:K15686 Q6ZN04 655 2.8e-66 RNA-binding protein MEX3B OS=Homo sapiens GN=MEX3B PE=1 SV=1 PF03854//PF00013//PF07650//PF13639//PF12678//PF14634//PF13014//PF00097 P-11 zinc finger//KH domain//KH domain//Ring finger domain//RING-H2 zinc finger//zinc-RING finger domain//KH domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0008270//GO:0003723//GO:0005515//GO:0046872 zinc ion binding//RNA binding//protein binding//metal ion binding -- -- KOG2113 Predicted RNA binding protein, contains KH domain Cluster-8309.54182 BP_3 116.05 0.95 6157 642935465 XP_008198021.1 297 1.5e-23 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X2 [Tribolium castaneum] 642935470 XM_967302.3 113 4.28098e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF01328 Peroxidase, family 2 GO:0006804//GO:0006979 obsolete peroxidase reaction//response to oxidative stress GO:0004601 peroxidase activity -- -- -- -- Cluster-8309.54183 BP_3 1016.72 5.02 10047 642935463 XP_008198020.1 3170 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X1 [Tribolium castaneum] 642935470 XM_967302.3 113 6.99872e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- Q6A0A9 763 9.0e-79 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 PF07690//PF00083//PF01328 Major Facilitator Superfamily//Sugar (and other) transporter//Peroxidase, family 2 GO:0055085//GO:0006979//GO:0006804 transmembrane transport//response to oxidative stress//obsolete peroxidase reaction GO:0022857//GO:0004601 transmembrane transporter activity//peroxidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.54188 BP_3 18.40 0.83 1365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5419 BP_3 44.22 0.90 2657 478256737 ENN76918.1 293 1.8e-23 hypothetical protein YQE_06565, partial [Dendroctonus ponderosae]>gi|546672595|gb|ERL84396.1| hypothetical protein D910_01829 [Dendroctonus ponderosae] 166208658 EU177511.1 42 5.39725e-10 Pinctada fucata shematrin-1 mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54193 BP_3 7.00 0.60 851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54194 BP_3 20.47 0.42 2643 91093683 XP_970017.1 1672 2.3e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 7.1e-76 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01553//PF00115//PF04589 Acyltransferase//Cytochrome C and Quinol oxidase polypeptide I//RFX1 transcription activation region GO:0009060//GO:0006123//GO:0006355//GO:0006118//GO:0015992//GO:0055114//GO:0008152 aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen//regulation of transcription, DNA-templated//obsolete electron transport//proton transport//oxidation-reduction process//metabolic process GO:0005506//GO:0003677//GO:0016746//GO:0009055//GO:0004129//GO:0020037 iron ion binding//DNA binding//transferase activity, transferring acyl groups//electron carrier activity//cytochrome-c oxidase activity//heme binding GO:0016021//GO:0005634//GO:0045277 integral component of membrane//nucleus//respiratory chain complex IV KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.54196 BP_3 1.00 0.47 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54202 BP_3 73.27 3.83 1214 642933983 XP_008197591.1 755 2.2e-77 PREDICTED: protein FAM45A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7G4 438 5.3e-42 Protein FAM45A OS=Danio rerio GN=fam45a PE=2 SV=1 PF03495 Clostridial binary toxin B/anthrax toxin PA GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.54203 BP_3 208.90 11.94 1135 642933983 XP_008197591.1 783 1.2e-80 PREDICTED: protein FAM45A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7G4 445 7.6e-43 Protein FAM45A OS=Danio rerio GN=fam45a PE=2 SV=1 PF03495 Clostridial binary toxin B/anthrax toxin PA GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.54204 BP_3 1925.65 34.44 2987 91080705 XP_975304.1 881 1.3e-91 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270005473|gb|EFA01921.1| hypothetical protein TcasGA2_TC007531 [Tribolium castaneum] -- -- -- -- -- K17352 TSPAN11 tetraspanin-11 http://www.genome.jp/dbget-bin/www_bget?ko:K17352 Q9QZA6 364 4.9e-33 CD151 antigen OS=Rattus norvegicus GN=Cd151 PE=1 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54208 BP_3 248.07 3.18 4052 478257589 ENN77743.1 1238 7.3e-133 hypothetical protein YQE_05813, partial [Dendroctonus ponderosae]>gi|546677142|gb|ERL88039.1| hypothetical protein D910_05428 [Dendroctonus ponderosae] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 792 1.6e-82 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF02254//PF02325//PF13241//PF01408//PF03435//PF00389//PF00899//PF03446//PF02826 TrkA-N domain//YGGT family//Putative NAD(P)-binding//Oxidoreductase family, NAD-binding Rossmann fold//Saccharopine dehydrogenase NADP binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//ThiF family//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006813//GO:0019354//GO:0008152//GO:0006098//GO:0055114//GO:0006779//GO:0019521 potassium ion transport//siroheme biosynthetic process//metabolic process//pentose-phosphate shunt//oxidation-reduction process//porphyrin-containing compound biosynthetic process//D-gluconate metabolic process GO:0051287//GO:0016616//GO:0016491//GO:0043115//GO:0008641//GO:0004616 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//precorrin-2 dehydrogenase activity//small protein activating enzyme activity//phosphogluconate dehydrogenase (decarboxylating) activity GO:0016020 membrane KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.54209 BP_3 13.00 2.05 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54215 BP_3 234.99 6.55 2022 332373998 AEE62140.1 738 3.5e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- K06694 PSMD10 26S proteasome non-ATPase regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06694 O75832 405 5.9e-38 26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens GN=PSMD10 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.54218 BP_3 327.24 3.23 5177 642935985 XP_008198257.1 561 3.0e-54 PREDICTED: uncharacterized protein LOC103314318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IG66 285 1.2e-23 Transmembrane protein 201 OS=Danio rerio GN=tmem201 PE=2 SV=1 PF06703//PF01680 Microsomal signal peptidase 25 kDa subunit (SPC25)//SOR/SNZ family GO:0042819//GO:0006465//GO:0042823 vitamin B6 biosynthetic process//signal peptide processing//pyridoxal phosphate biosynthetic process GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane KOG4623 Uncharacterized conserved protein Cluster-8309.54222 BP_3 41.17 0.59 3656 641654576 XP_008179259.1 844 3.2e-87 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A2T812 773 2.3e-80 Zinc finger protein 287 OS=Pongo pygmaeus GN=ZNF287 PE=3 SV=1 PF16622//PF13912//PF07975//PF00096//PF13465 zinc-finger C2H2-type//C2H2-type zinc finger//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.54225 BP_3 32.90 1.78 1184 861599125 KMQ83546.1 396 9.3e-36 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54226 BP_3 11.03 0.43 1522 270010525 EFA06973.1 213 2.0e-14 hypothetical protein TcasGA2_TC009933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54227 BP_3 19.00 0.70 1592 -- -- -- -- -- 797056881 HG313998.1 34 8.97437e-06 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 20 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5423 BP_3 110.64 2.18 2742 478251152 ENN71628.1 1655 2.2e-181 hypothetical protein YQE_11727, partial [Dendroctonus ponderosae]>gi|546685814|gb|ERL95257.1| hypothetical protein D910_12524 [Dendroctonus ponderosae] 642926333 XM_008196659.1 246 2.20169e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q3V3A7 523 1.7e-51 RING finger protein 207 OS=Mus musculus GN=Rnf207 PE=2 SV=2 PF05791//PF10392//PF04728//PF08702//PF04513//PF11802//PF04673//PF01667 Bacillus haemolytic enterotoxin (HBL)//Golgi transport complex subunit 5//Lipoprotein leucine-zipper//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Centromere-associated protein K//Polyketide synthesis cyclase//Ribosomal protein S27 GO:0030168//GO:0006891//GO:0006412//GO:0042254//GO:0007165//GO:0009405//GO:0030639//GO:0051258 platelet activation//intra-Golgi vesicle-mediated transport//translation//ribosome biogenesis//signal transduction//pathogenesis//polyketide biosynthetic process//protein polymerization GO:0030674//GO:0003735//GO:0005102//GO:0005198 protein binding, bridging//structural constituent of ribosome//receptor binding//structural molecule activity GO:0017119//GO:0016020//GO:0005634//GO:0019867//GO:0019031//GO:0005840//GO:0005622//GO:0005577//GO:0019028 Golgi transport complex//membrane//nucleus//outer membrane//viral envelope//ribosome//intracellular//fibrinogen complex//viral capsid -- -- Cluster-8309.54233 BP_3 4.00 0.31 915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54234 BP_3 209.73 1.43 7348 478256459 ENN76644.1 2724 6.5e-305 hypothetical protein YQE_06823, partial [Dendroctonus ponderosae] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 1598 9.9e-176 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF05148//PF10391//PF05206//PF08241//PF05175 Hypothetical methyltransferase//Fingers domain of DNA polymerase lambda//Methyltransferase TRM13//Methyltransferase domain//Methyltransferase small domain GO:0008152//GO:0008033 metabolic process//tRNA processing GO:0008168//GO:0003677//GO:0034061 methyltransferase activity//DNA binding//DNA polymerase activity GO:0005634 nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.54236 BP_3 104.80 1.01 5309 642917556 XP_008191255.1 2663 5.6e-298 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.76506e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 247 3.2e-19 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.54238 BP_3 7.00 0.34 1294 195119400 XP_002004219.1 172 9.6e-10 GI19798 [Drosophila mojavensis]>gi|193909287|gb|EDW08154.1| GI19798 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- Q80VQ0 130 2.9e-06 Aldehyde dehydrogenase family 3 member B1 OS=Mus musculus GN=Aldh3b1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152//GO:0044710 oxidation-reduction process//metabolic process//single-organism metabolic process GO:0016491//GO:0016620 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.54247 BP_3 42.01 0.42 5145 642922648 XP_008193260.1 1734 2.9e-190 PREDICTED: coiled-coil and C2 domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18260 CC2D1 coiled-coil and C2 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18260 Q29M42 1205 2.6e-130 Coiled-coil and C2 domain-containing protein 1-like OS=Drosophila pseudoobscura pseudoobscura GN=GA18377 PE=3 SV=2 PF00168//PF04097//PF00711 C2 domain//Nup93/Nic96//Beta defensin GO:0006952//GO:0006810 defense response//transport GO:0005515 protein binding GO:0005643//GO:0005576 nuclear pore//extracellular region KOG3837 Uncharacterized conserved protein, contains DM14 and C2 domains Cluster-8309.5425 BP_3 1.55 0.56 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54254 BP_3 25.81 0.58 2437 170027856 XP_001841813.1 169 4.0e-09 g-protein coupled receptor [Culex quinquefasciatus]>gi|167862383|gb|EDS25766.1| g-protein coupled receptor [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54255 BP_3 15.43 0.62 1498 91081511 XP_974643.1 666 5.8e-67 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 Q9JHW5 525 5.3e-52 Vesicle-associated membrane protein 7 OS=Rattus norvegicus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.54261 BP_3 771.46 21.57 2016 828177651 AKK25148.1 438 2.1e-40 chemosensory protein 4 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 251 4.2e-20 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF06209//PF08613//PF00957//PF01299 Cofactor of BRCA1 (COBRA1)//Cyclin//Synaptobrevin//Lysosome-associated membrane glycoprotein (Lamp) GO:0016192//GO:0000079//GO:0045892 vesicle-mediated transport//regulation of cyclin-dependent protein serine/threonine kinase activity//negative regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0016020//GO:0005634//GO:0016021 membrane//nucleus//integral component of membrane -- -- Cluster-8309.54262 BP_3 69.39 1.79 2156 642935609 XP_008198080.1 2765 3.4e-310 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7C5 1453 1.9e-159 Phosphatidylinositide phosphatase SAC2 OS=Danio rerio GN=inpp5f PE=3 SV=1 PF03092//PF02383//PF03611 BT1 family//SacI homology domain//PTS system sugar-specific permease component GO:0009401//GO:0006810 phosphoenolpyruvate-dependent sugar phosphotransferase system//transport GO:0042578 phosphoric ester hydrolase activity GO:0016021 integral component of membrane KOG1889 Putative phosphoinositide phosphatase Cluster-8309.54263 BP_3 205.94 3.64 3018 642936951 XP_008198626.1 327 2.4e-27 PREDICTED: protein ENL [Tribolium castaneum]>gi|270000916|gb|EEZ97363.1| hypothetical protein TcasGA2_TC011185 [Tribolium castaneum] -- -- -- -- -- K15187 MLLT1_3, ENL, AF9 YEATS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15187 P42568 147 7.3e-08 Protein AF-9 OS=Homo sapiens GN=MLLT3 PE=1 SV=2 PF03286//PF09768 Pox virus Ag35 surface protein//Peptidase M76 family -- -- GO:0004222 metalloendopeptidase activity GO:0019031 viral envelope -- -- Cluster-8309.54267 BP_3 345.99 39.21 717 91080999 XP_975088.1 382 2.4e-34 PREDICTED: mannose-6-phosphate isomerase [Tribolium castaneum]>gi|270005346|gb|EFA01794.1| hypothetical protein TcasGA2_TC007395 [Tribolium castaneum] -- -- -- -- -- K01809 manA, MPI mannose-6-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01809 Q8HXX2 297 6.9e-26 Mannose-6-phosphate isomerase OS=Macaca fascicularis GN=MPI PE=2 SV=3 PF01238 Phosphomannose isomerase type I GO:0044238//GO:0006013//GO:0006000//GO:0005975//GO:0071704 primary metabolic process//mannose metabolic process//fructose metabolic process//carbohydrate metabolic process//organic substance metabolic process GO:0008270//GO:0004476//GO:0016853 zinc ion binding//mannose-6-phosphate isomerase activity//isomerase activity -- -- KOG2757 Mannose-6-phosphate isomerase Cluster-8309.54268 BP_3 1.00 35.97 213 -- -- -- -- -- 507148294 NR_103097.1 198 7.1073e-98 Pseudoalteromonas haloplanktis strain TAC125 23S ribosomal RNA gene, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54274 BP_3 295.11 3.02 5005 642928077 XP_008200146.1 1753 1.7e-192 PREDICTED: homer protein homolog 2 [Tribolium castaneum]>gi|270010897|gb|EFA07345.1| hypothetical protein TcasGA2_TC015941 [Tribolium castaneum] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 Q9QWW1 681 1.4e-69 Homer protein homolog 2 OS=Mus musculus GN=Homer2 PE=1 SV=1 PF10473//PF07989//PF03938//PF07926//PF00038//PF16940//PF15898//PF16716//PF06703//PF13851//PF06810 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Outer membrane protein (OmpH-like)//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Chloroplast envelope transporter//cGMP-dependent protein kinase interacting domain//Bone marrow stromal antigen 2//Microsomal signal peptidase 25 kDa subunit (SPC25)//Growth-arrest specific micro-tubule binding//Phage minor structural protein GP20 GO:0006606//GO:0048870//GO:0006465//GO:0051607 protein import into nucleus//cell motility//signal peptide processing//defense response to virus GO:0019901//GO:0051082//GO:0008233//GO:0008134//GO:0045502//GO:0005198//GO:0042803 protein kinase binding//unfolded protein binding//peptidase activity//transcription factor binding//dynein binding//structural molecule activity//protein homodimerization activity GO:0009507//GO:0005787//GO:0031514//GO:0005815//GO:0016021//GO:0005882//GO:0030286//GO:0005667 chloroplast//signal peptidase complex//motile cilium//microtubule organizing center//integral component of membrane//intermediate filament//dynein complex//transcription factor complex -- -- Cluster-8309.54275 BP_3 10.00 0.37 1610 -- -- -- -- -- 558484710 KF564809.1 49 4.1643e-14 Melipona yucatanica isolate MyucMer2 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, complete sequence; and 5.8S ribosomal RNA gene, partial sequence >gnl|BL_ORD_ID|25926407 Melipona yucatanica isolate MyucMer3 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, complete sequence; and 5.8S ribosomal RNA gene, partial sequence >gnl|BL_ORD_ID|25926407 Melipona yucatanica isolate MyucMer4 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, complete sequence; and 5.8S ribosomal RNA gene, partial sequence >gnl|BL_ORD_ID|25926407 Melipona yucatanica isolate MyucMer5 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, complete sequence; and 5.8S ribosomal RNA gene, partial sequence >gnl|BL_ORD_ID|25926407 Melipona yucatanica isolate MyucMer6 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, complete sequence; and 5.8S ribosomal RNA gene, partial sequence >gnl|BL_ORD_ID|25926407 Melipona yucatanica isolate MyucMer7 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, complete sequence; and 5.8S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- PF04566 RNA polymerase Rpb2, domain 4 GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.54276 BP_3 163.00 2.68 3226 270009219 EFA05667.1 1914 2.4e-211 lim1 [Tribolium castaneum] 642926611 XM_008196718.1 618 0 PREDICTED: Tribolium castaneum LIM/homeobox protein Lhx5 (LOC657972), transcript variant X2, mRNA K09372 LHX1 LIM homeobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09372 P52889 847 5.3e-89 LIM/homeobox protein Lhx5 OS=Danio rerio GN=lhx5 PE=2 SV=1 PF05920//PF00412//PF00046 Homeobox KN domain//LIM domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.54280 BP_3 12.94 0.63 1278 642933728 XP_008197338.1 1822 4.4e-201 PREDICTED: transmembrane protein 132B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q24JP5 211 1.2e-15 Transmembrane protein 132A OS=Homo sapiens GN=TMEM132A PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54281 BP_3 81.05 2.19 2073 270016968 EFA13414.1 2409 6.2e-269 hypothetical protein TcasGA2_TC010300 [Tribolium castaneum] 701368608 XM_010009070.1 66 1.91081e-23 PREDICTED: Chaetura pelagica tripartite motif containing 37 (TRIM37), mRNA K10608 TRIM37, MUL tripartite motif-containing protein 37 http://www.genome.jp/dbget-bin/www_bget?ko:K10608 Q6PCX9 1742 5.6e-193 E3 ubiquitin-protein ligase TRIM37 OS=Mus musculus GN=Trim37 PE=1 SV=1 PF00643//PF01442//PF04632//PF00917 B-box zinc finger//Apolipoprotein A1/A4/E domain//Fusaric acid resistance protein family//MATH domain GO:0042157//GO:0006869//GO:0006810 lipoprotein metabolic process//lipid transport//transport GO:0008289//GO:0005515//GO:0008270 lipid binding//protein binding//zinc ion binding GO:0005886//GO:0005576//GO:0005622 plasma membrane//extracellular region//intracellular -- -- Cluster-8309.54282 BP_3 88.00 4.51 1233 642940459 XP_008196455.1 401 2.5e-36 PREDICTED: uncharacterized protein LOC661701 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54285 BP_3 44.00 1.07 2272 124107284 BAF45419.1 1378 2.4e-149 arrestin1 precursor [Dianemobius nigrofasciatus] 195117905 XM_002003450.1 56 7.59711e-18 Drosophila mojavensis GI17937 (Dmoj\GI17937), mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1253 3.1e-136 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 PF00367//PF11909 phosphotransferase system, EIIB//NADH-quinone oxidoreductase cyanobacterial subunit N GO:0006118//GO:0008643//GO:0055114 obsolete electron transport//carbohydrate transport//oxidation-reduction process GO:0008982//GO:0016655 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0009357//GO:0016020 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane KOG3865 Arrestin Cluster-8309.54286 BP_3 74.00 2.43 1762 815791214 XP_012216180.1 1232 1.6e-132 PREDICTED: arrestin homolog [Linepithema humile] -- -- -- -- -- K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P32122 1227 2.5e-133 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 PF05294 Scorpion short toxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG3865 Arrestin Cluster-8309.54288 BP_3 747.45 9.10 4252 642915350 XP_008190583.1 906 2.4e-94 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- K17410 MRPS31 small subunit ribosomal protein S31 http://www.genome.jp/dbget-bin/www_bget?ko:K17410 P82925 417 5.0e-39 28S ribosomal protein S31, mitochondrial OS=Bos taurus GN=MRPS31 PE=1 SV=3 PF15965//PF15433//PF03145 TRAF-like zinc-finger//Mitochondrial 28S ribosomal protein S31//Seven in absentia protein family GO:0006511//GO:0042254//GO:0007275 ubiquitin-dependent protein catabolic process//ribosome biogenesis//multicellular organismal development GO:0003735//GO:0008270 structural constituent of ribosome//zinc ion binding GO:0005840//GO:0005634//GO:0005763 ribosome//nucleus//mitochondrial small ribosomal subunit KOG3002 Zn finger protein Cluster-8309.5429 BP_3 54.07 2.08 1547 642920521 XP_008192385.1 1179 1.9e-126 PREDICTED: uncharacterized protein LOC663775 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96BD5 189 5.0e-13 PHD finger protein 21A OS=Homo sapiens GN=PHF21A PE=1 SV=1 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54291 BP_3 6.43 0.81 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54294 BP_3 42.69 1.59 1585 808127576 XP_012166717.1 344 1.3e-29 PREDICTED: uncharacterized protein LOC105666020 [Bombus terrestris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.54295 BP_3 211.54 2.19 4940 270013369 EFA09817.1 818 4.5e-84 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- K17963 PPRC1, PRC peroxisome proliferator-activated receptor gamma coactivator-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17963 Q6NZN1 232 1.7e-17 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Mus musculus GN=Pprc1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.54299 BP_3 6.91 1.18 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.543 BP_3 2.00 0.65 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54300 BP_3 148.11 9.20 1068 332374952 AEE62617.1 735 4.1e-75 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q922Q1 198 3.1e-14 Mitochondrial amidoxime reducing component 2 OS=Mus musculus GN=Marc2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54304 BP_3 1098.36 5.83 9379 642937090 XP_008198688.1 1740 1.0e-190 PREDICTED: nose resistant to fluoxetine protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 585 3.7e-58 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF17123//PF17122//PF13639 Acyltransferase family//RING-like zinc finger//Zinc-finger//Ring finger domain -- -- GO:0005515//GO:0016747//GO:0008270 protein binding//transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- -- -- Cluster-8309.54306 BP_3 221.82 2.12 5324 270014503 EFA10951.1 4359 0.0e+00 hypothetical protein TcasGA2_TC004111 [Tribolium castaneum] 665818753 XM_008559999.1 110 1.72069e-47 PREDICTED: Microplitis demolitor putative DNA helicase Ino80 (LOC103578813), mRNA K11665 INO80, INOC1 DNA helicase INO80 http://www.genome.jp/dbget-bin/www_bget?ko:K11665 Q9VDY1 2634 5.3e-296 Putative DNA helicase Ino80 OS=Drosophila melanogaster GN=Ino80 PE=1 SV=2 PF00176//PF13892 SNF2 family N-terminal domain//DNA-binding domain -- -- GO:0003677//GO:0005524 DNA binding//ATP binding -- -- KOG0388 SNF2 family DNA-dependent ATPase Cluster-8309.54307 BP_3 306.36 13.02 1426 642918280 XP_008191442.1 832 3.1e-86 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 642918281 XM_008193221.1 184 3.30751e-89 PREDICTED: Tribolium castaneum UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (LOC655930), transcript variant X2, mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 732 5.0e-76 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13174//PF13181//PF07721//PF13176//PF13414//PF13371//PF00515//PF13374 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.54308 BP_3 389.15 21.05 1183 332374122 AEE62202.1 703 2.3e-71 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9D0I8 565 9.6e-57 mRNA turnover protein 4 homolog OS=Mus musculus GN=Mrto4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0816 Protein involved in mRNA turnover Cluster-8309.54309 BP_3 83.75 10.96 660 189241797 XP_001812480.1 300 7.0e-25 PREDICTED: cytochrome c oxidase subunit 6C [Tribolium castaneum]>gi|270001250|gb|EEZ97697.1| hypothetical protein TcasGA2_TC011006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04038 152 4.2e-09 Cytochrome c oxidase subunit 6C OS=Bos taurus GN=COX6C PE=1 SV=2 -- -- GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.54312 BP_3 22.47 0.38 3130 478255321 ENN75547.1 632 1.1e-62 hypothetical protein YQE_07890, partial [Dendroctonus ponderosae] 828207244 XM_012701764.1 66 2.89999e-23 PREDICTED: Hydra vulgaris aspartate--tRNA ligase, cytoplasmic-like (LOC100205952), mRNA K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 Q922B2 385 1.9e-35 Aspartate--tRNA ligase, cytoplasmic OS=Mus musculus GN=Dars PE=2 SV=2 PF11538//PF00152 Snurportin1//tRNA synthetases class II (D, K and N) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812//GO:0005515 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity//protein binding -- -- KOG0556 Aspartyl-tRNA synthetase Cluster-8309.54316 BP_3 29.28 0.32 4706 478254095 ENN74383.1 3675 0.0e+00 hypothetical protein YQE_09040, partial [Dendroctonus ponderosae] -- -- -- -- -- K02332 POLG1 DNA polymerase gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02332 Q27607 2892 0.0e+00 DNA polymerase subunit gamma-1, mitochondrial OS=Drosophila melanogaster GN=tam PE=1 SV=2 PF01612//PF00476//PF01300//PF07834//PF01176 3'-5' exonuclease//DNA polymerase family A//Telomere recombination//RanGAP1 C-terminal domain//Translation initiation factor 1A / IF-1 GO:0006139//GO:0006446//GO:0007165//GO:0006413//GO:0006260 nucleobase-containing compound metabolic process//regulation of translational initiation//signal transduction//translational initiation//DNA replication GO:0003887//GO:0003723//GO:0003677//GO:0005096//GO:0003743//GO:0003725//GO:0008408//GO:0003676 DNA-directed DNA polymerase activity//RNA binding//DNA binding//GTPase activator activity//translation initiation factor activity//double-stranded RNA binding//3'-5' exonuclease activity//nucleic acid binding GO:0042575//GO:0005840 DNA polymerase complex//ribosome KOG3657 Mitochondrial DNA polymerase gamma, catalytic subunit Cluster-8309.54317 BP_3 179.58 3.06 3118 478257137 ENN77300.1 376 5.1e-33 hypothetical protein YQE_06126, partial [Dendroctonus ponderosae]>gi|546681456|gb|ERL91553.1| hypothetical protein D910_08883 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05273 Poxvirus RNA polymerase 22 kDa subunit GO:0006206//GO:0019083//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//viral transcription//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.5432 BP_3 3.24 0.41 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54320 BP_3 40.00 0.34 5939 817085753 XP_012265576.1 3784 0.0e+00 PREDICTED: glycogen debranching enzyme isoform X2 [Athalia rosae] 704284494 XM_010174344.1 87 1.1725e-34 PREDICTED: Caprimulgus carolinensis amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (AGL), partial mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 Q2PQH8 3337 0.0e+00 Glycogen debranching enzyme OS=Canis familiaris GN=AGL PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3625 Alpha amylase Cluster-8309.54322 BP_3 43.43 0.56 4049 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03323//PF03391 Bacillus/Clostridium GerA spore germination protein//Nepovirus coat protein, central domain GO:0009847 spore germination GO:0005198 structural molecule activity GO:0016021//GO:0019028 integral component of membrane//viral capsid -- -- Cluster-8309.54329 BP_3 14.00 0.45 1804 270001046 EEZ97493.1 167 5.1e-09 hypothetical protein TcasGA2_TC011335 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B7Z0K8 165 3.6e-10 Collagen alpha chain CG42342 OS=Drosophila melanogaster GN=CG42342 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.54330 BP_3 120.27 0.95 6375 546676741 ERL87697.1 411 9.1e-37 hypothetical protein D910_05087 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 212 4.5e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF02008 CXXC zinc finger domain -- -- GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- -- -- Cluster-8309.54331 BP_3 12246.73 201.37 3223 546676741 ERL87697.1 467 1.5e-43 hypothetical protein D910_05087 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 220 2.7e-16 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF02008//PF00379 CXXC zinc finger domain//Insect cuticle protein -- -- GO:0042302//GO:0003677//GO:0008270 structural constituent of cuticle//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.54332 BP_3 428.54 30.14 977 642936711 XP_008200418.1 1073 2.4e-114 PREDICTED: eukaryotic initiation factor 4E isoform X1 [Tribolium castaneum] 642936710 XM_008202196.1 160 4.92435e-76 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4E (eIF-4E), transcript variant X1, mRNA K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 O60573 608 8.2e-62 Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens GN=EIF4E2 PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005737//GO:0005840 cytoplasm//ribosome KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.54334 BP_3 58.71 9.88 578 270012966 EFA09414.1 154 5.2e-08 hypothetical protein TcasGA2_TC005216 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54337 BP_3 7.17 0.70 785 642934075 XP_008196143.1 327 6.2e-28 PREDICTED: sin3 histone deacetylase corepressor complex component SDS3 [Tribolium castaneum]>gi|270012950|gb|EFA09398.1| hypothetical protein TcasGA2_TC004316 [Tribolium castaneum] 347964404 XM_559379.4 34 4.33003e-06 Anopheles gambiae str. PEST AGAP000738-PA (AgaP_AGAP000738) mRNA, complete cds K19201 SUDS3, SAP45 Sin3 histone deacetylase corepressor complex component SDS3 http://www.genome.jp/dbget-bin/www_bget?ko:K19201 Q9H7L9 179 3.7e-12 Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens GN=SUDS3 PE=1 SV=2 PF02046 Cytochrome c oxidase subunit VIa GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743//GO:0005751 respiratory chain complex IV//mitochondrial inner membrane//mitochondrial respiratory chain complex IV -- -- Cluster-8309.54338 BP_3 22.64 0.60 2099 158298785 XP_553715.3 203 3.9e-13 AGAP009835-PA [Anopheles gambiae str. PEST]>gi|157014052|gb|EAL39215.3| AGAP009835-PA [Anopheles gambiae str. PEST] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q92887 184 2.6e-12 Canalicular multispecific organic anion transporter 1 OS=Homo sapiens GN=ABCC2 PE=1 SV=3 PF01120 Alpha-L-fucosidase GO:0055085//GO:0006200//GO:0006810//GO:0005975 transmembrane transport//obsolete ATP catabolic process//transport//carbohydrate metabolic process GO:0004560//GO:0005524//GO:0042626 alpha-L-fucosidase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.5434 BP_3 1.03 0.93 338 546678020 ERL88744.1 144 4.4e-07 hypothetical protein D910_06126 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54342 BP_3 5.00 0.34 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54343 BP_3 1372.48 15.26 4628 91093699 XP_966579.1 1805 1.5e-198 PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|270014224|gb|EFA10672.1| hypothetical protein TcasGA2_TC010654, partial [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VXD9 988 3.4e-105 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF00002//PF00503 7 transmembrane receptor (Secretin family)//G-protein alpha subunit GO:0007186//GO:0007166//GO:0007165 G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway//signal transduction GO:0019001//GO:0004871//GO:0004888//GO:0031683//GO:0004930//GO:0003924 guanyl nucleotide binding//signal transducer activity//transmembrane signaling receptor activity//G-protein beta/gamma-subunit complex binding//G-protein coupled receptor activity//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.54344 BP_3 156.80 2.48 3338 91093699 XP_966579.1 1001 1.8e-105 PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|270014224|gb|EFA10672.1| hypothetical protein TcasGA2_TC010654, partial [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VXD9 679 1.6e-69 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF00503//PF00002 G-protein alpha subunit//7 transmembrane receptor (Secretin family) GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0004930//GO:0031683//GO:0004871//GO:0019001 GTPase activity//G-protein coupled receptor activity//G-protein beta/gamma-subunit complex binding//signal transducer activity//guanyl nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.54345 BP_3 26.17 0.48 2913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54347 BP_3 53.37 0.95 2996 332376975 AEE63627.1 1323 7.6e-143 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 118 3.43976e-52 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1198 9.7e-130 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF00382//PF01857//PF02984 Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain//Cyclin, C-terminal domain GO:0051726 regulation of cell cycle GO:0017025 TBP-class protein binding GO:0005634 nucleus KOG1597 Transcription initiation factor TFIIB Cluster-8309.54348 BP_3 37.45 1.11 1923 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845 Spore germination protein GO:0009847 spore germination -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54349 BP_3 5.00 1.20 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54350 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54351 BP_3 25.00 9.55 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54355 BP_3 2.00 2.16 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54358 BP_3 45.64 2.23 1279 642920916 XP_008192614.1 157 5.2e-08 PREDICTED: outer dense fiber protein 3 isoform X3 [Tribolium castaneum] 462345164 APGK01034774.1 43 7.11972e-11 Dendroctonus ponderosae Seq01034784, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5436 BP_3 8.86 0.34 1535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54360 BP_3 58.30 3.27 1150 642924852 XP_008194066.1 738 2.0e-75 PREDICTED: nuclear migration protein nudC [Tribolium castaneum] 642924851 XM_008195844.1 184 2.65445e-89 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- Q9Y266 550 5.1e-55 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.54361 BP_3 776.66 13.30 3106 91084489 XP_971806.1 713 4.2e-72 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103 CD20-like family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54363 BP_3 23.40 0.77 1751 642922712 XP_008193292.1 145 1.7e-06 PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922714|ref|XP_008193293.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922716|ref|XP_008193294.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922718|ref|XP_008193295.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54367 BP_3 5.01 0.45 823 91077286 XP_974471.1 266 7.6e-21 PREDICTED: probable phosphoserine aminotransferase [Tribolium castaneum]>gi|270001676|gb|EEZ98123.1| hypothetical protein TcasGA2_TC000542 [Tribolium castaneum] -- -- -- -- -- K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 P10658 218 1.2e-16 Phosphoserine aminotransferase OS=Oryctolagus cuniculus GN=PSAT1 PE=2 SV=1 -- -- GO:0006544//GO:0006564//GO:0042816//GO:0006566//GO:0006563 glycine metabolic process//L-serine biosynthetic process//vitamin B6 metabolic process//threonine metabolic process//L-serine metabolic process GO:0030170//GO:0004648 pyridoxal phosphate binding//O-phospho-L-serine:2-oxoglutarate aminotransferase activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.54368 BP_3 26.94 0.31 4435 642939403 XP_008193263.1 1963 6.9e-217 PREDICTED: protein FAM135A [Tribolium castaneum]>gi|270016463|gb|EFA12909.1| hypothetical protein TcasGA2_TC006979 [Tribolium castaneum] 642939402 XM_008195041.1 369 0 PREDICTED: Tribolium castaneum protein FAM135A (LOC661082), mRNA -- -- -- -- Q5RA75 1083 3.1e-116 Protein FAM135A OS=Pongo abelii GN=FAM135A PE=2 SV=1 PF07819 PGAP1-like protein GO:0006505//GO:0006886 GPI anchor metabolic process//intracellular protein transport GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2205 Uncharacterized conserved protein Cluster-8309.54373 BP_3 33.82 2.05 1088 91090139 XP_971650.1 274 1.2e-21 PREDICTED: WEB family protein At3g02930, chloroplastic [Tribolium castaneum]>gi|270013743|gb|EFA10191.1| hypothetical protein TcasGA2_TC012383 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54374 BP_3 7.09 0.84 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54377 BP_3 93.62 0.88 5399 546686113 ERL95505.1 501 2.8e-47 hypothetical protein D910_12767 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957//PF02706//PF10798//PF00520//PF05434 Commissureless//Chain length determinant protein//Biofilm development protein YmgB/AriR//Ion transport protein//TMEM9 GO:0007411//GO:0009103//GO:0055085//GO:0071229//GO:0006811//GO:0042710 axon guidance//lipopolysaccharide biosynthetic process//transmembrane transport//cellular response to acid chemical//ion transport//biofilm formation GO:0005216 ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.54381 BP_3 17.00 1.23 958 478257567 ENN77721.1 244 3.2e-18 hypothetical protein YQE_05792, partial [Dendroctonus ponderosae]>gi|546675129|gb|ERL86373.1| hypothetical protein D910_03781 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9C6W5 134 7.4e-07 ABC transporter G family member 14 OS=Arabidopsis thaliana GN=ABCG14 PE=2 SV=1 PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.54383 BP_3 6.16 0.95 605 91082333 XP_974678.1 327 4.7e-28 PREDICTED: sugar transporter SWEET1 [Tribolium castaneum]>gi|270008305|gb|EFA04753.1| hypothetical protein TcasGA2_TC030574 [Tribolium castaneum] -- -- -- -- -- K15382 SLC50A, SWEET solute carrier family 50 (sugar transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K15382 Q7JVE7 246 4.8e-20 Sugar transporter SWEET1 OS=Drosophila melanogaster GN=slv PE=1 SV=1 PF03083 Sugar efflux transporter for intercellular exchange GO:0008643//GO:0006310 carbohydrate transport//DNA recombination -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG1623 Multitransmembrane protein Cluster-8309.54386 BP_3 415.90 5.86 3715 642929553 XP_008195882.1 2577 3.7e-288 PREDICTED: DNA excision repair protein ERCC-6-like [Tribolium castaneum] 645002912 XM_008209837.1 96 7.25602e-40 PREDICTED: Nasonia vitripennis DNA excision repair protein ERCC-6-like (LOC100118952), transcript variant X3, mRNA K10841 ERCC6, CSB, RAD26 DNA excision repair protein ERCC-6 http://www.genome.jp/dbget-bin/www_bget?ko:K10841 Q03468 1642 3.9e-181 DNA excision repair protein ERCC-6 OS=Homo sapiens GN=ERCC6 PE=1 SV=1 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) Cluster-8309.54389 BP_3 6.97 0.72 758 546678765 ERL89317.1 597 2.9e-59 hypothetical protein D910_06689 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769//PF03824 Divalent cation transporter//High-affinity nickel-transport protein GO:0015675//GO:0006812//GO:0035444 nickel cation transport//cation transport//nickel cation transmembrane transport GO:0046872//GO:0015099//GO:0008324 metal ion binding//nickel cation transmembrane transporter activity//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG4740 Uncharacterized conserved protein Cluster-8309.5439 BP_3 733.86 20.82 1991 91091470 XP_973218.1 867 3.8e-90 PREDICTED: peroxisomal membrane protein 11C [Tribolium castaneum]>gi|270000949|gb|EEZ97396.1| hypothetical protein TcasGA2_TC011223 [Tribolium castaneum] -- -- -- -- -- K13353 PEX11C peroxin-11C http://www.genome.jp/dbget-bin/www_bget?ko:K13353 Q96HA9 375 1.7e-34 Peroxisomal membrane protein 11C OS=Homo sapiens GN=PEX11G PE=1 SV=1 PF07194//PF05648 P2 response regulator binding domain//Peroxisomal biogenesis factor 11 (PEX11) GO:0016559//GO:0016310//GO:0000160//GO:0006928 peroxisome fission//phosphorylation//phosphorelay signal transduction system//movement of cell or subcellular component GO:0004673//GO:0000155 protein histidine kinase activity//phosphorelay sensor kinase activity GO:0005779//GO:0009365 integral component of peroxisomal membrane//protein histidine kinase complex KOG4186 Peroxisomal biogenesis protein (peroxin) Cluster-8309.54391 BP_3 71.30 3.24 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54392 BP_3 136.32 1.51 4644 642914198 XP_008201586.1 3946 0.0e+00 PREDICTED: uncharacterized protein LOC661711 isoform X2 [Tribolium castaneum] 642914197 XM_008203364.1 579 0 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.8e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF07647//PF00536//PF15360//PF04904//PF00018 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//APJ endogenous ligand//NAB conserved region 1 (NCD1)//SH3 domain GO:0045892//GO:0007165 negative regulation of transcription, DNA-templated//signal transduction GO:0031704//GO:0005515//GO:0005179 apelin receptor binding//protein binding//hormone activity GO:0005634 nucleus -- -- Cluster-8309.54396 BP_3 121.28 2.99 2246 642940025 XP_008191587.1 2573 6.4e-288 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P08487 1593 1.1e-175 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Bos taurus GN=PLCG1 PE=1 SV=1 PF00018//PF14604//PF03009 SH3 domain//Variant SH3 domain//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:0005515//GO:0008081 protein binding//phosphoric diester hydrolase activity -- -- KOG1264 Phospholipase C Cluster-8309.54397 BP_3 173.63 10.99 1053 270015871 EFA12319.1 1095 7.3e-117 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P19174 416 1.6e-39 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens GN=PLCG1 PE=1 SV=1 PF13499//PF13405//PF00036//PF13833 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.54399 BP_3 360.72 9.91 2047 270015871 EFA12319.1 2664 1.6e-298 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P08487 1627 1.2e-179 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Bos taurus GN=PLCG1 PE=1 SV=1 PF14604//PF00018//PF03009 Variant SH3 domain//SH3 domain//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:0005515//GO:0008081 protein binding//phosphoric diester hydrolase activity -- -- KOG1264 Phospholipase C Cluster-8309.54400 BP_3 254.15 6.24 2254 759078999 XP_011349304.1 1444 5.3e-157 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [Cerapachys biroi] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P19174 807 1.6e-84 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens GN=PLCG1 PE=1 SV=1 PF00168//PF00387 C2 domain//Phosphatidylinositol-specific phospholipase C, Y domain GO:0009395//GO:0046339//GO:0007165//GO:0006629//GO:0035556 phospholipid catabolic process//diacylglycerol metabolic process//signal transduction//lipid metabolic process//intracellular signal transduction GO:0004435//GO:0005515 phosphatidylinositol phospholipase C activity//protein binding -- -- KOG1264 Phospholipase C Cluster-8309.54401 BP_3 811.12 9.57 4377 270297228 NP_001161905.1 744 1.5e-75 cuticular protein analogous to peritrophins 1-C precursor [Tribolium castaneum]>gi|268309004|gb|ACY95468.1| cuticular protein analogous to peritrophins 1-C [Tribolium castaneum]>gi|270001482|gb|EEZ97929.1| hypothetical protein TcasGA2_TC000316 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.54402 BP_3 131.63 1.52 4476 270297228 NP_001161905.1 663 3.8e-66 cuticular protein analogous to peritrophins 1-C precursor [Tribolium castaneum]>gi|268309004|gb|ACY95468.1| cuticular protein analogous to peritrophins 1-C [Tribolium castaneum]>gi|270001482|gb|EEZ97929.1| hypothetical protein TcasGA2_TC000316 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.54408 BP_3 32.05 0.55 3079 270011563 EFA08011.1 1016 3.1e-107 hypothetical protein TcasGA2_TC005600 [Tribolium castaneum] 808137079 XM_012315443.1 86 2.1739e-34 PREDICTED: Bombus terrestris paired mesoderm homeobox protein 2B (LOC100648767), mRNA -- -- -- -- Q8BYH0 351 1.6e-31 Dorsal root ganglia homeobox protein OS=Mus musculus GN=Drgx PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.54409 BP_3 142.55 3.63 2187 642917040 XP_008191094.1 1744 8.4e-192 PREDICTED: uncharacterized protein C18orf8 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DM3 810 6.9e-85 Uncharacterized protein C18orf8 OS=Homo sapiens GN=C18orf8 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2377 Uncharacterized conserved protein Cluster-8309.54410 BP_3 38.30 0.40 4891 642924251 XP_008194216.1 4002 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19464 PLEKHG5 pleckstrin homology domain-containing family G member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K19464 Q6RFZ7 762 5.7e-79 Pleckstrin homology domain-containing family G member 5 OS=Rattus norvegicus GN=Plekhg5 PE=1 SV=1 PF02313//PF02196//PF00621 Fumarate reductase subunit D//Raf-like Ras-binding domain//RhoGEF domain GO:0007165//GO:0043087//GO:0035023//GO:0006106 signal transduction//regulation of GTPase activity//regulation of Rho protein signal transduction//fumarate metabolic process GO:0005057//GO:0005089 receptor signaling protein activity//Rho guanyl-nucleotide exchange factor activity GO:0016020 membrane KOG3521 Predicted guanine nucleotide exchange factor Cluster-8309.54412 BP_3 3.03 0.31 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54413 BP_3 513.30 10.97 2547 665800358 XP_008548139.1 704 3.8e-71 PREDICTED: G1/S-specific cyclin-D2 [Microplitis demolitor]>gi|607303972|gb|EZA45348.1| g1/S-specific cyclin-D2-like protein [Microplitis demolitor] -- -- -- -- -- K10151 CCND2 cyclin D2 http://www.genome.jp/dbget-bin/www_bget?ko:K10151 P30281 485 3.9e-47 G1/S-specific cyclin-D3 OS=Homo sapiens GN=CCND3 PE=1 SV=2 PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.54415 BP_3 37.87 1.43 1568 751960459 AJG05482.1 250 1.0e-18 poor imd response upon knock-in, partial [Sitophilus oryzae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5442 BP_3 60.49 0.63 4916 332372560 AEE61422.1 791 6.1e-81 unknown [Dendroctonus ponderosae]>gi|478257372|gb|ENN77530.1| hypothetical protein YQE_05978, partial [Dendroctonus ponderosae]>gi|546685343|gb|ERL94870.1| hypothetical protein D910_12143 [Dendroctonus ponderosae] -- -- -- -- -- K10687 UBE2F ubiquitin-conjugating enzyme E2 F http://www.genome.jp/dbget-bin/www_bget?ko:K10687 Q5M8Y2 566 3.1e-56 NEDD8-conjugating enzyme UBE2F OS=Xenopus tropicalis GN=ube2f PE=2 SV=1 PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0005737//GO:0016020 cytoplasm//membrane KOG0420 Ubiquitin-protein ligase Cluster-8309.54420 BP_3 151.78 4.44 1940 546674387 ERL85774.1 2121 1.4e-235 hypothetical protein D910_03189 [Dendroctonus ponderosae] -- -- -- -- -- K06628 CDC45 cell division control protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K06628 Q9YHZ6 1194 1.8e-129 Cell division control protein 45 homolog OS=Xenopus laevis GN=cdc45 PE=1 SV=2 PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- KOG2475 CDC45 (cell division cycle 45)-like protein Cluster-8309.54421 BP_3 198.59 1.87 5422 642917556 XP_008191255.1 3201 0.0e+00 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.80288e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 257 2.3e-20 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.54422 BP_3 44.53 0.39 5766 642917556 XP_008191255.1 2250 4.7e-250 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.91803e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 257 2.4e-20 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621//PF09298 RhoGEF domain//Fumarylacetoacetase N-terminal GO:0042207//GO:0043087//GO:0009072//GO:0006570//GO:0035023 styrene catabolic process//regulation of GTPase activity//aromatic amino acid family metabolic process//tyrosine metabolic process//regulation of Rho protein signal transduction GO:0004334//GO:0005089//GO:0005543 fumarylacetoacetase activity//Rho guanyl-nucleotide exchange factor activity//phospholipid binding GO:0005622 intracellular -- -- Cluster-8309.54423 BP_3 47.61 2.25 1311 642922712 XP_008193292.1 409 3.2e-37 PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922714|ref|XP_008193293.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922716|ref|XP_008193294.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922718|ref|XP_008193295.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61969 206 4.5e-15 LIM domain transcription factor LMO4 OS=Mus musculus GN=Lmo4 PE=1 SV=1 PF13639//PF00412//PF17123 Ring finger domain//LIM domain//RING-like zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.54425 BP_3 5.00 0.53 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54426 BP_3 86.34 1.16 3891 91092536 XP_967769.1 2382 1.6e-265 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 515 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1611 1.6e-177 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0016773//GO:0004674//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.54429 BP_3 1.01 0.86 342 546675679 ERL86823.1 240 3.3e-18 hypothetical protein D910_04226 [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 156 7.4e-10 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF00287 Sodium / potassium ATPase beta chain GO:0006813//GO:0006814 potassium ion transport//sodium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.54432 BP_3 308.98 3.10 5096 642926382 XP_008194902.1 3527 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Tribolium castaneum] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q505D1 2365 7.9e-265 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF02891//PF09066//PF00023 Ankyrin repeat//MIZ/SP-RING zinc finger//Beta2-adaptin appendage, C-terminal sub-domain//Ankyrin repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0030131 clathrin adaptor complex -- -- Cluster-8309.54437 BP_3 45.24 2.63 1120 91078738 XP_967649.1 892 2.7e-93 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] 195153530 XM_002017643.1 50 7.98602e-15 Drosophila persimilis GL17308 (Dper\GL17308), mRNA -- -- -- -- Q6DC39 570 2.4e-57 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.54438 BP_3 17.31 1.49 851 91078738 XP_967649.1 739 1.1e-75 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] 195153530 XM_002017643.1 50 6.0079e-15 Drosophila persimilis GL17308 (Dper\GL17308), mRNA -- -- -- -- Q6DC39 456 3.0e-44 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.54440 BP_3 57.36 1.93 1721 549084995 BAO00915.1 1987 4.4e-220 broad-complex [Psacothea hilaris]>gi|549150203|dbj|BAO01153.1| broad-complex [Psacothea hilaris] 549150202 AB858990.1 1079 0 Psacothea hilaris PhBR-C_Z2Z3 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q24206 611 6.5e-62 Broad-complex core protein isoform 6 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00096//PF06221//PF02148//PF05443//PF13465//PF16622//PF00651//PF01428//PF13912//PF01363//PF02892 Zinc finger, C2H2 type//Putative zinc finger motif, C2HC5-type//Zn-finger in ubiquitin-hydrolases and other protein//ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//zinc-finger C2H2-type//BTB/POZ domain//AN1-like Zinc finger//C2H2-type zinc finger//FYVE zinc finger//BED zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0005515//GO:0046872 zinc ion binding//DNA binding//protein binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.54441 BP_3 83.23 0.34 12017 549084993 BAO00914.1 2003 4.3e-221 broad-complex [Psacothea hilaris] 549084992 AB857715.1 1041 0 Psacothea hilaris PhBR-C_Z1 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q01295 609 7.8e-61 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF02892//PF03854//PF13912//PF01363//PF00651//PF16622//PF13465//PF00096//PF00130 BED zinc finger//P-11 zinc finger//C2H2-type zinc finger//FYVE zinc finger//BTB/POZ domain//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515//GO:0046872//GO:0003677//GO:0008270//GO:0003723 protein binding//metal ion binding//DNA binding//zinc ion binding//RNA binding -- -- -- -- Cluster-8309.54445 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54449 BP_3 143.64 1.25 5850 642926380 XP_008194901.1 2852 0.0e+00 PREDICTED: uncharacterized protein LOC655777 [Tribolium castaneum] 641673871 XM_001952487.3 158 3.92495e-74 PREDICTED: Acyrthosiphon pisum uncharacterized LOC100160518 (LOC100160518), partial mRNA -- -- -- -- Q9JJZ8 911 3.6e-96 Cyclic nucleotide-gated cation channel alpha-3 OS=Mus musculus GN=Cnga3 PE=1 SV=2 PF03938//PF00520 Outer membrane protein (OmpH-like)//Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0051082//GO:0005216 unfolded protein binding//ion channel activity GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.54450 BP_3 11.00 2.10 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54460 BP_3 7.00 0.32 1351 546674635 ERL85978.1 177 2.6e-10 hypothetical protein D910_03392 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54461 BP_3 7.00 0.60 857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54462 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54463 BP_3 1.00 2.22 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54469 BP_3 36.09 1.69 1318 546672343 ERL84251.1 671 1.3e-67 hypothetical protein D910_01632 [Dendroctonus ponderosae]>gi|546672458|gb|ERL84312.1| hypothetical protein D910_01724 [Dendroctonus ponderosae] -- -- -- -- -- K09648 IMP2 mitochondrial inner membrane protease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09648 Q6AZD4 491 4.1e-48 Mitochondrial inner membrane protease subunit 2 OS=Danio rerio GN=immp2l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1568 Mitochondrial inner membrane protease, subunit IMP2 Cluster-8309.54470 BP_3 20.00 0.86 1407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54473 BP_3 19.61 0.55 2001 642915071 XP_008190398.1 2322 7.3e-259 PREDICTED: protein groucho isoform X4 [Tribolium castaneum] 602715430 XM_007467859.1 376 0 PREDICTED: Lipotes vexillifer transducin-like enhancer of split 3 (TLE3), transcript variant X12, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 1950 4.1e-217 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.54474 BP_3 21.66 0.37 3127 332373836 AEE62059.1 1480 4.9e-161 unknown [Dendroctonus ponderosae]>gi|478256081|gb|ENN76280.1| hypothetical protein YQE_07244, partial [Dendroctonus ponderosae] -- -- -- -- -- K03846 ALG9 alpha-1,2-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03846 Q8VDI9 866 3.2e-91 Alpha-1,2-mannosyltransferase ALG9 OS=Mus musculus GN=Alg9 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2515 Mannosyltransferase Cluster-8309.54477 BP_3 218.78 2.49 4535 270011590 EFA08038.1 2613 3.0e-292 hypothetical protein TcasGA2_TC005627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ET47 449 1.0e-42 Espin OS=Mus musculus GN=Espn PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54478 BP_3 2474.65 17.86 6971 91080871 XP_972325.1 2663 7.3e-298 PREDICTED: nidogen-1 [Tribolium castaneum]>gi|270005920|gb|EFA02368.1| hypothetical protein TcasGA2_TC008043 [Tribolium castaneum] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 3.4e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF00661//PF07645//PF12861//PF13639//PF01731//PF12678//PF00008//PF06119//PF11789 Viral matrix protein//Calcium-binding EGF domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Arylesterase//RING-H2 zinc finger//EGF-like domain//Nidogen-like//Zinc-finger of the MIZ type in Nse subunit GO:0016567//GO:0007160//GO:0019068 protein ubiquitination//cell-matrix adhesion//virion assembly GO:0005198//GO:0004842//GO:0005515//GO:0008270//GO:0005509//GO:0004064 structural molecule activity//ubiquitin-protein transferase activity//protein binding//zinc ion binding//calcium ion binding//arylesterase activity GO:0005680 anaphase-promoting complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.54480 BP_3 124.21 1.34 4771 478258004 ENN78142.1 1189 4.2e-127 hypothetical protein YQE_05296, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3T8J9 309 1.9e-26 GON-4-like protein OS=Homo sapiens GN=GON4L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54481 BP_3 100.69 1.26 4135 270010376 EFA06824.1 2606 1.8e-291 hypothetical protein TcasGA2_TC009766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13590 263 3.5e-21 Neural cell adhesion molecule 1 OS=Gallus gallus GN=NCAM1 PE=1 SV=3 PF00041//PF13895//PF15880//PF02480 Fibronectin type III domain//Immunoglobulin domain//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial//Alphaherpesvirus glycoprotein E -- -- GO:0005515 protein binding GO:0016020//GO:0005739//GO:0005747 membrane//mitochondrion//mitochondrial respiratory chain complex I -- -- Cluster-8309.54482 BP_3 5.00 0.47 810 270013657 EFA10105.1 590 2.0e-58 hypothetical protein TcasGA2_TC012284 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P08542 421 3.3e-40 UDP-glucuronosyltransferase 2B17 OS=Rattus norvegicus GN=Ugt2b17 PE=2 SV=2 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.54483 BP_3 44.47 1.87 1439 270015480 EFA11928.1 1042 1.4e-110 hypothetical protein TcasGA2_TC004274 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 500 4.0e-49 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.54492 BP_3 106.01 0.72 7433 546684778 ERL94373.1 3133 0.0e+00 hypothetical protein D910_11653 [Dendroctonus ponderosae] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 1698 2.5e-187 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF08241//PF05175//PF05148//PF00270//PF10391//PF05206 Methyltransferase domain//Methyltransferase small domain//Hypothetical methyltransferase//DEAD/DEAH box helicase//Fingers domain of DNA polymerase lambda//Methyltransferase TRM13 GO:0008033//GO:0008152 tRNA processing//metabolic process GO:0008168//GO:0003676//GO:0034061//GO:0005524//GO:0003677 methyltransferase activity//nucleic acid binding//DNA polymerase activity//ATP binding//DNA binding GO:0005634 nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.54501 BP_3 78.21 5.79 943 478251178 ENN71654.1 912 1.1e-95 hypothetical protein YQE_11752, partial [Dendroctonus ponderosae] -- -- -- -- -- K18180 COA7, SELRC1, RESA1 cytochrome c oxidase assembly factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18180 Q9W5N0 736 1.1e-76 Cytochrome c oxidase assembly factor 7 homolog OS=Drosophila melanogaster GN=CG13865 PE=1 SV=1 PF13176 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4014 Uncharacterized conserved protein (contains TPR repeat) Cluster-8309.54502 BP_3 236.83 2.83 4331 642938610 XP_008199864.1 3216 0.0e+00 PREDICTED: protein trachealess [Tribolium castaneum] 820805579 KP147944.1 572 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1104 1.1e-118 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF00989//PF00010//PF04551//PF08447 PAS fold//Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold GO:0055114//GO:0016114//GO:0006355 oxidation-reduction process//terpenoid biosynthetic process//regulation of transcription, DNA-templated GO:0046983//GO:0005515//GO:0046429 protein dimerization activity//protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity -- -- -- -- Cluster-8309.54504 BP_3 399.13 5.36 3883 642918532 XP_008191511.1 676 1.0e-67 PREDICTED: microcephalin [Tribolium castaneum] -- -- -- -- -- K19403 MCPH1 microcephalin http://www.genome.jp/dbget-bin/www_bget?ko:K19403 P61590 331 4.3e-29 Microcephalin OS=Colobus guereza GN=MCPH1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54508 BP_3 9.92 2.26 503 242017388 XP_002429171.1 319 3.3e-27 TATA-binding protein-associated factor, putative [Pediculus humanus corporis]>gi|212514049|gb|EEB16433.1| TATA-binding protein-associated factor, putative [Pediculus humanus corporis] 831521961 XM_012862362.1 90 2.00843e-37 PREDICTED: Fundulus heteroclitus BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (btaf1), mRNA K15192 BTAF1, MOT1 TATA-binding protein-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15192 O14981 307 3.4e-27 TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 PF05433 Glycine zipper 2TM domain -- -- GO:0016740//GO:0003677//GO:0005524//GO:0004386 transferase activity//DNA binding//ATP binding//helicase activity GO:0019867 outer membrane KOG0392 SNF2 family DNA-dependent ATPase domain-containing protein Cluster-8309.54513 BP_3 133.00 4.29 1786 758213862 AJO62244.1 1724 1.4e-189 chemosensory ionotropic receptor IR6 [Tenebrio molitor] -- -- -- -- -- K05313 GRIN glutamate receptor, ionotropic, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05313 P42264 168 1.6e-10 Glutamate receptor ionotropic, kainate 3 OS=Rattus norvegicus GN=Grik3 PE=1 SV=1 PF10613 Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-8309.54514 BP_3 708.12 12.51 3021 189235122 XP_001811652.1 3243 0.0e+00 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 510 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1936 2.6e-215 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF00856//PF01496//PF05602 SET domain//V-type ATPase 116kDa subunit family//Cleft lip and palate transmembrane protein 1 (CLPTM1) GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0003682//GO:0015078//GO:0005515 chromatin binding//hydrogen ion transmembrane transporter activity//protein binding GO:0033179//GO:0016021//GO:0000785 proton-transporting V-type ATPase, V0 domain//integral component of membrane//chromatin KOG1079 Transcriptional repressor EZH1 Cluster-8309.54516 BP_3 42.00 1.95 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54517 BP_3 36.49 2.08 1139 449083364 NP_001263355.1 776 7.7e-80 dehydrogenase/reductase SDR family member 4 [Tribolium castaneum]>gi|270003836|gb|EFA00284.1| hypothetical protein TcasGA2_TC003117 [Tribolium castaneum] -- -- -- -- -- K11147 DHRS4 dehydrogenase/reductase SDR family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11147 Q9GKX2 568 4.2e-57 Dehydrogenase/reductase SDR family member 4 (Fragment) OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1 PF00106//PF02737//PF01370 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0006631//GO:0006568//GO:0006554//GO:0006552//GO:0055114//GO:0006574//GO:0006550//GO:0018874//GO:0006633//GO:0008152 fatty acid metabolic process//tryptophan metabolic process//lysine catabolic process//leucine catabolic process//oxidation-reduction process//valine catabolic process//isoleucine catabolic process//benzoate metabolic process//fatty acid biosynthetic process//metabolic process GO:0003857//GO:0050662//GO:0003824//GO:0016491 3-hydroxyacyl-CoA dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.54520 BP_3 6.32 0.51 892 270000836 EEZ97283.1 386 1.0e-34 hypothetical protein TcasGA2_TC011087 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IE24 245 9.3e-20 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Rattus norvegicus GN=Usp54 PE=2 SV=2 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.54522 BP_3 66.70 4.40 1023 642938512 XP_008195463.1 612 7.2e-61 PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum]>gi|642938514|ref|XP_008195504.1| PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00591 COQ3 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00591 Q63159 430 3.8e-41 Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Rattus norvegicus GN=Coq3 PE=2 SV=2 PF08241 Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG1270 Methyltransferases Cluster-8309.54525 BP_3 49.65 0.98 2732 91077680 XP_974637.1 1934 9.8e-214 PREDICTED: pre-mRNA-splicing factor Slu7 [Tribolium castaneum]>gi|270001533|gb|EEZ97980.1| hypothetical protein TcasGA2_TC000375 [Tribolium castaneum] 762095952 XM_011432193.1 51 5.50872e-15 PREDICTED: Crassostrea gigas pre-mRNA-splicing factor SLU7-like (LOC105330483), transcript variant X2, mRNA K12819 SLU7 pre-mRNA-processing factor SLU7 http://www.genome.jp/dbget-bin/www_bget?ko:K12819 Q9VAQ7 1403 1.5e-153 Pre-mRNA-splicing factor Slu7 OS=Drosophila melanogaster GN=Slu7 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2560 RNA splicing factor - Slu7p Cluster-8309.54528 BP_3 388.63 3.84 5164 642931184 XP_008196473.1 2454 9.3e-274 PREDICTED: mediator of RNA polymerase II transcription subunit 1 [Tribolium castaneum]>gi|270012110|gb|EFA08558.1| hypothetical protein TcasGA2_TC006213 [Tribolium castaneum] -- -- -- -- -- K15144 MED1 mediator of RNA polymerase II transcription subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15144 Q172G3 1280 5.2e-139 Mediator of RNA polymerase II transcription subunit 1 OS=Aedes aegypti GN=AAEL007402 PE=3 SV=1 PF04810//PF10744 Sec23/Sec24 zinc finger//Mediator of RNA polymerase II transcription subunit 1 GO:0006357//GO:0006888//GO:0006886 regulation of transcription from RNA polymerase II promoter//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0001104 zinc ion binding//RNA polymerase II transcription cofactor activity GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.54531 BP_3 57.33 1.17 2658 642938306 XP_008192805.1 208 1.3e-13 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X3 [Tribolium castaneum] 642938318 XM_008194620.1 57 2.47676e-18 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X11, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 -- -- -- -- PF02173 pKID domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-8309.54533 BP_3 48.83 0.83 3125 478251603 ENN72065.1 1404 3.2e-152 hypothetical protein YQE_11351 [Dendroctonus ponderosae]>gi|546674287|gb|ERL85698.1| hypothetical protein D910_03113 [Dendroctonus ponderosae] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q9QXL7 838 5.6e-88 Nucleoside diphosphate kinase 7 OS=Rattus norvegicus GN=Nme7 PE=1 SV=1 PF00334//PF05175//PF08241 Nucleoside diphosphate kinase//Methyltransferase small domain//Methyltransferase domain GO:0006228//GO:0006241//GO:0006206//GO:0006165//GO:0006144//GO:0008152//GO:0006183 UTP biosynthetic process//CTP biosynthetic process//pyrimidine nucleobase metabolic process//nucleoside diphosphate phosphorylation//purine nucleobase metabolic process//metabolic process//GTP biosynthetic process GO:0008168//GO:0004550 methyltransferase activity//nucleoside diphosphate kinase activity -- -- KOG2651 rRNA adenine N-6-methyltransferase Cluster-8309.54534 BP_3 2.85 0.31 732 642916400 XP_008191007.1 297 1.7e-24 PREDICTED: protein cueball [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54539 BP_3 27.03 0.69 2185 478251603 ENN72065.1 1404 2.2e-152 hypothetical protein YQE_11351 [Dendroctonus ponderosae]>gi|546674287|gb|ERL85698.1| hypothetical protein D910_03113 [Dendroctonus ponderosae] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q9QXL7 838 3.9e-88 Nucleoside diphosphate kinase 7 OS=Rattus norvegicus GN=Nme7 PE=1 SV=1 PF00334 Nucleoside diphosphate kinase GO:0006144//GO:0006183//GO:0006228//GO:0006165//GO:0006241//GO:0006206 purine nucleobase metabolic process//GTP biosynthetic process//UTP biosynthetic process//nucleoside diphosphate phosphorylation//CTP biosynthetic process//pyrimidine nucleobase metabolic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.54543 BP_3 175.31 1.44 6168 642924926 XP_008194100.1 2756 1.1e-308 PREDICTED: low affinity cationic amino acid transporter 2 [Tribolium castaneum]>gi|270008027|gb|EFA04475.1| hypothetical protein TcasGA2_TC014779 [Tribolium castaneum] 642924925 XM_008195878.1 40 1.6323e-08 PREDICTED: Tribolium castaneum low affinity cationic amino acid transporter 2 (LOC100142535), mRNA K13871 SLC7A14 solute carrier family 7 (cationic amino acid transporter), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13871 Q8BXR1 922 2.0e-97 Probable cationic amino acid transporter OS=Mus musculus GN=Slc7a14 PE=1 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0006810//GO:0055085//GO:0003333//GO:0006865 transport//transmembrane transport//amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.54545 BP_3 46.95 0.96 2657 270011563 EFA08011.1 491 2.0e-46 hypothetical protein TcasGA2_TC005600 [Tribolium castaneum] 571568585 XM_006565036.1 36 1.1683e-06 PREDICTED: Apis mellifera uncharacterized LOC724120 (LOC724120), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54547 BP_3 384.80 4.14 4773 478251175 ENN71651.1 1844 4.7e-203 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2N4 902 3.3e-95 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.54548 BP_3 99.06 1.94 2753 328699094 XP_003240827.1 1053 1.4e-111 PREDICTED: uncharacterized protein LOC100571979 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF00628//PF05225 DDE superfamily endonuclease//PHD-finger//helix-turn-helix, Psq domain -- -- GO:0005515//GO:0003676//GO:0003677 protein binding//nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.54551 BP_3 46.45 3.46 938 91094511 XP_971832.1 572 2.9e-56 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] -- -- -- -- -- K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 Q9Z2X1 425 1.3e-40 Heterogeneous nuclear ribonucleoprotein F OS=Mus musculus GN=Hnrnpf PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.54552 BP_3 50.48 1.38 2050 642920057 XP_008192187.1 1719 6.2e-189 PREDICTED: mitochondrial import inner membrane translocase subunit TIM44 [Tribolium castaneum] -- -- -- -- -- K17804 TIM44 mitochondrial import inner membrane translocase subunit TIM44 http://www.genome.jp/dbget-bin/www_bget?ko:K17804 O43615 1037 3.1e-111 Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens GN=TIMM44 PE=1 SV=2 PF07926//PF05478//PF08336//PF07464//PF02932 TPR/MLP1/MLP2-like protein//Prominin//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Apolipophorin-III precursor (apoLp-III)//Neurotransmitter-gated ion-channel transmembrane region GO:0006525//GO:0018401//GO:0006869//GO:0006560//GO:0006606//GO:0055114//GO:0006811 arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//lipid transport//proline metabolic process//protein import into nucleus//oxidation-reduction process//ion transport GO:0004656//GO:0008289//GO:0016702 procollagen-proline 4-dioxygenase activity//lipid binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016021//GO:0005783//GO:0005576//GO:0016020 integral component of membrane//endoplasmic reticulum//extracellular region//membrane KOG2580 Mitochondrial import inner membrane translocase, subunit TIM44 Cluster-8309.54554 BP_3 19.82 0.67 1723 189236906 XP_001809986.1 771 4.4e-79 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 390 2.8e-36 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.54555 BP_3 17425.42 773.91 1377 478251437 ENN71902.1 503 4.2e-48 hypothetical protein YQE_11439, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54560 BP_3 38.69 0.42 4703 270012924 EFA09372.1 815 9.6e-84 hypothetical protein TcasGA2_TC001933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54561 BP_3 97.89 1.14 4439 270012924 EFA09372.1 815 9.0e-84 hypothetical protein TcasGA2_TC001933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54562 BP_3 34.57 0.79 2409 642934141 XP_008199293.1 525 2.1e-50 PREDICTED: uncharacterized protein LOC103314619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54568 BP_3 62.17 0.81 3978 642921365 XP_972788.2 3206 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 2.07183e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1259 1.1e-136 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF12678//PF12861//PF00787//PF00097//PF13639 RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//PX domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain GO:0016567 protein ubiquitination GO:0005515//GO:0035091//GO:0046872//GO:0004842//GO:0008270 protein binding//phosphatidylinositol binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.5457 BP_3 25.64 0.69 2072 642937575 XP_008199104.1 489 2.7e-46 PREDICTED: uncharacterized protein LOC103314532 [Tribolium castaneum]>gi|270001210|gb|EEZ97657.1| hypothetical protein TcasGA2_TC016201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF00036 THAP domain//EF hand -- -- GO:0003676//GO:0005509 nucleic acid binding//calcium ion binding -- -- -- -- Cluster-8309.54574 BP_3 7.24 0.31 1405 642915257 XP_008190546.1 977 4.7e-103 PREDICTED: alpha-tubulin N-acetyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K19573 ATAT1, MEC17 alpha-tubulin N-acetyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19573 Q16Y34 605 2.6e-61 Alpha-tubulin N-acetyltransferase OS=Aedes aegypti GN=AAEL008679 PE=3 SV=1 PF13673//PF03494//PF00583//PF13508//PF05301 Acetyltransferase (GNAT) domain//Beta-amyloid peptide (beta-APP)//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17 GO:0042967//GO:0071929 acyl-carrier-protein biosynthetic process//alpha-tubulin acetylation GO:0019799//GO:0008080 tubulin N-acetyltransferase activity//N-acetyltransferase activity GO:0016021//GO:0005874//GO:0045298 integral component of membrane//microtubule//tubulin complex KOG4601 Uncharacterized conserved protein Cluster-8309.54576 BP_3 57.00 1.02 2998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54577 BP_3 2.00 1.29 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54578 BP_3 13.84 2.23 591 478259929 ENN79731.1 478 1.4e-45 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 257 2.5e-21 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF09243 Mitochondrial small ribosomal subunit Rsm22 GO:0006412 translation GO:0008168 methyltransferase activity -- -- KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.54582 BP_3 52.10 1.00 2801 759178516 XP_011378476.1 220 5.6e-15 PREDICTED: targeting protein for Xklp2 [Pteropus vampyrus] -- -- -- -- -- -- -- -- -- Q5RAF2 182 5.9e-12 Targeting protein for Xklp2 OS=Pongo abelii GN=TPX2 PE=2 SV=1 PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.54585 BP_3 1.00 0.57 373 189235393 XP_001810875.1 225 2.0e-16 PREDICTED: targeting protein for Xklp2 [Tribolium castaneum]>gi|270003583|gb|EFA00031.1| hypothetical protein TcasGA2_TC002838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54588 BP_3 67.22 1.25 2877 189235393 XP_001810875.1 455 3.2e-42 PREDICTED: targeting protein for Xklp2 [Tribolium castaneum]>gi|270003583|gb|EFA00031.1| hypothetical protein TcasGA2_TC002838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E2RYF8 271 2.9e-22 Targeting protein for Xklp2 homolog OS=Patiria pectinifera GN=TPX2 PE=2 SV=1 PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.5459 BP_3 7.00 0.33 1318 641651350 XP_008190094.1 160 2.4e-08 PREDICTED: uncharacterized protein LOC103311957 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54591 BP_3 124.04 2.90 2356 270014462 EFA10910.1 267 1.7e-20 hypothetical protein TcasGA2_TC001736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54592 BP_3 10.00 1.74 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54595 BP_3 300.83 17.53 1119 642929450 XP_008195846.1 904 1.1e-94 PREDICTED: serine/threonine-protein kinase D3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06070 PKD protein kinase D http://www.genome.jp/dbget-bin/www_bget?ko:K06070 Q8K1Y2 462 8.0e-45 Serine/threonine-protein kinase D3 OS=Mus musculus GN=Prkd3 PE=1 SV=1 PF00628//PF05191//PF00130 PHD-finger//Adenylate kinase, active site lid//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006144//GO:0046034//GO:0035556 purine nucleobase metabolic process//ATP metabolic process//intracellular signal transduction GO:0005515//GO:0004017 protein binding//adenylate kinase activity -- -- KOG4236 Serine/threonine protein kinase PKC mu/PKD and related proteins Cluster-8309.54596 BP_3 850.98 10.74 4110 478255815 ENN76023.1 2410 9.4e-269 hypothetical protein YQE_07399, partial [Dendroctonus ponderosae] -- -- -- -- -- K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q9EP53 482 1.4e-46 Hamartin OS=Mus musculus GN=Tsc1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.54597 BP_3 59.00 3.36 1137 270010513 EFA06961.1 502 4.5e-48 hypothetical protein TcasGA2_TC009919 [Tribolium castaneum] -- -- -- -- -- K15199 GTF3C1 general transcription factor 3C polypeptide 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15199 Q12789 323 1.1e-28 General transcription factor 3C polypeptide 1 OS=Homo sapiens GN=GTF3C1 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5460 BP_3 31.00 0.81 2139 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54602 BP_3 489.11 4.27 5807 642929357 XP_008195802.1 2106 2.4e-233 PREDICTED: uncharacterized protein LOC100142360 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12789 770 8.0e-80 General transcription factor 3C polypeptide 1 OS=Homo sapiens GN=GTF3C1 PE=1 SV=4 PF04186 FxsA cytoplasmic membrane protein -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.54605 BP_3 26.83 0.64 2308 270016648 EFA13094.1 464 2.4e-43 hypothetical protein TcasGA2_TC012963 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03277 163 7.8e-10 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Fragment) OS=Bradysia coprophila PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1075 FOG: Reverse transcriptase Cluster-8309.54606 BP_3 2.00 2.91 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54608 BP_3 2054.55 15.98 6487 91091098 XP_968555.1 1977 2.4e-218 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270014078|gb|EFA10526.1| hypothetical protein TcasGA2_TC012778 [Tribolium castaneum] -- -- -- -- -- K05684 ABCG8 ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2) http://www.genome.jp/dbget-bin/www_bget?ko:K05684 Q99PE7 367 4.8e-33 ATP-binding cassette sub-family G member 5 OS=Rattus norvegicus GN=Abcg5 PE=2 SV=3 PF01061//PF06422//PF00005//PF08352 ABC-2 type transporter//CDR ABC transporter//ABC transporter//Oligopeptide/dipeptide transporter, C-terminal region GO:0015833//GO:0006810//GO:0006200 peptide transport//transport//obsolete ATP catabolic process GO:0042626//GO:0016887//GO:0000166//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//nucleotide binding//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.54610 BP_3 1775.06 14.72 6102 91091098 XP_968555.1 1661 9.9e-182 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270014078|gb|EFA10526.1| hypothetical protein TcasGA2_TC012778 [Tribolium castaneum] -- -- -- -- -- K05684 ABCG8 ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2) http://www.genome.jp/dbget-bin/www_bget?ko:K05684 Q9H221 414 1.6e-38 ATP-binding cassette sub-family G member 8 OS=Homo sapiens GN=ABCG8 PE=1 SV=1 PF01061//PF06422//PF00005 ABC-2 type transporter//CDR ABC transporter//ABC transporter GO:0006200//GO:0006810 obsolete ATP catabolic process//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0016020 integral component of membrane//membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.54613 BP_3 167.97 7.30 1401 189240973 XP_967534.2 1507 1.6e-164 PREDICTED: TNF receptor-associated factor 4 isoform X1 [Tribolium castaneum] 746832798 XM_011061811.1 84 1.26275e-33 PREDICTED: Acromyrmex echinatior TNF receptor-associated factor 4 (LOC105149400), transcript variant X4, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 796 1.9e-83 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF15965//PF02176//PF03145 TRAF-like zinc-finger//TRAF-type zinc finger//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.54615 BP_3 121.46 1.04 5910 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54616 BP_3 1525.49 15.02 5188 478262931 ENN81354.1 5338 0.0e+00 hypothetical protein YQE_02244, partial [Dendroctonus ponderosae]>gi|546674076|gb|ERL85556.1| hypothetical protein D910_02975 [Dendroctonus ponderosae] 827549416 XM_004927285.2 162 2.07848e-76 PREDICTED: Bombyx mori tankyrase (LOC101740141), mRNA K10799 TNKS tankyrase http://www.genome.jp/dbget-bin/www_bget?ko:K10799 Q9VBP3 4501 0.0e+00 Tankyrase OS=Drosophila melanogaster GN=Tnks PE=1 SV=1 PF00023//PF00322//PF13606//PF00644//PF00536//PF07647 Ankyrin repeat//Endothelin family//Ankyrin repeat//Poly(ADP-ribose) polymerase catalytic domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0019229 regulation of vasoconstriction GO:0003950//GO:0005515 NAD+ ADP-ribosyltransferase activity//protein binding GO:0005576 extracellular region KOG4177 Ankyrin Cluster-8309.54618 BP_3 21.18 0.48 2404 641681966 XP_008189661.1 241 1.8e-17 PREDICTED: general transcription factor II-I repeat domain-containing protein 2-like, partial [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- A4IFA3 190 6.0e-13 General transcription factor II-I repeat domain-containing protein 2 OS=Bos taurus GN=GTF2IRD2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54622 BP_3 46.18 1.42 1861 478256893 ENN77062.1 359 2.8e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 2.9e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF13912//PF05485//PF00096//PF13465//PF07975 C2H2-type zinc finger//THAP domain//Zinc finger, C2H2 type//Zinc-finger double domain//TFIIH C1-like domain GO:0006281 DNA repair GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.54624 BP_3 51.45 1.19 2382 642927423 XP_008195266.1 1097 9.7e-117 PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum]>gi|642927425|ref|XP_008195267.1| PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54625 BP_3 40.56 1.54 1560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54627 BP_3 69.85 1.33 2830 642914898 XP_008190435.1 1139 1.5e-121 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 736 3.4e-76 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF14249//PF00028 Tocopherol cyclase//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0009976//GO:0005509 tocopherol cyclase activity//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.5463 BP_3 6.00 1.59 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54633 BP_3 49.32 1.88 1555 674034550 XP_008839429.1 531 2.7e-51 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like [Nannospalax galili] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q32M78 499 5.7e-49 Zinc finger protein 699 OS=Homo sapiens GN=ZNF699 PE=1 SV=1 PF07975//PF07934//PF13465//PF03326//PF16622//PF13912//PF00096//PF07776 TFIIH C1-like domain//8-oxoguanine DNA glycosylase, N-terminal domain//Zinc-finger double domain//Herpesvirus transcription activation factor (transactivator)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0006308//GO:0006289//GO:0006285//GO:0006355//GO:0006281 DNA catabolic process//nucleotide-excision repair//base-excision repair, AP site formation//regulation of transcription, DNA-templated//DNA repair GO:0046872//GO:0003684//GO:0008270//GO:0008534 metal ion binding//damaged DNA binding//zinc ion binding//oxidized purine nucleobase lesion DNA N-glycosylase activity GO:0005634 nucleus -- -- Cluster-8309.54637 BP_3 17.00 1.65 787 642913740 XP_008201142.1 345 5.0e-30 PREDICTED: serine/threonine-protein kinase PLK4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64702 136 3.6e-07 Serine/threonine-protein kinase PLK4 OS=Mus musculus GN=Plk4 PE=1 SV=2 PF00659 POLO box duplicated region -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54640 BP_3 6.00 0.75 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54641 BP_3 12.49 0.32 2191 546684930 ERL94512.1 1688 2.6e-185 hypothetical protein D910_11789 [Dendroctonus ponderosae] -- -- -- -- -- K18083 MTMR6_7_8 myotubularin-related protein 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K18083 Q96EF0 941 4.5e-100 Myotubularin-related protein 8 OS=Homo sapiens GN=MTMR8 PE=1 SV=1 PF00102//PF13639//PF01363//PF00782 Protein-tyrosine phosphatase//Ring finger domain//FYVE zinc finger//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0005515//GO:0008138//GO:0004725//GO:0046872//GO:0008270 protein binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//metal ion binding//zinc ion binding -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.54643 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54647 BP_3 11.00 2.32 520 91080705 XP_975304.1 217 2.3e-15 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270005473|gb|EFA01921.1| hypothetical protein TcasGA2_TC007531 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00083 Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.54652 BP_3 19.00 0.32 3185 -- -- -- -- -- 51872140 AY626793.1 97 1.72681e-40 Litopenaeus vannamei G protein beta 1 subunit mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54653 BP_3 314.45 5.91 2858 270005700 EFA02148.1 305 8.0e-25 hypothetical protein TcasGA2_TC007800 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01484//PF10473 Nematode cuticle collagen N-terminal domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 -- -- GO:0042302//GO:0008134//GO:0045502//GO:0042803 structural constituent of cuticle//transcription factor binding//dynein binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.54654 BP_3 763.77 7.25 5369 91082805 XP_968057.1 1207 3.8e-129 PREDICTED: beta-1,3-galactosyltransferase 6 [Tribolium castaneum] -- -- -- -- -- K00734 B3GALT6 galactosylxylosylprotein 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00734 Q9N491 438 2.3e-41 Beta-1,3-galactosyltransferase sqv-2 OS=Caenorhabditis elegans GN=sqv-2 PE=2 SV=1 PF01762 Galactosyltransferase GO:0006486 protein glycosylation GO:0008378 galactosyltransferase activity GO:0016020 membrane KOG2288 Galactosyltransferases Cluster-8309.54657 BP_3 46.30 2.53 1173 91079546 XP_971272.1 196 1.4e-12 PREDICTED: uncharacterized protein LOC659913 [Tribolium castaneum]>gi|270003419|gb|EEZ99866.1| hypothetical protein TcasGA2_TC002648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03505//PF10717 Clostridium enterotoxin//Occlusion-derived virus envelope protein ODV-E18 GO:0009405 pathogenesis -- -- GO:0005576//GO:0019031 extracellular region//viral envelope -- -- Cluster-8309.54658 BP_3 38.58 0.57 3538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54660 BP_3 254.82 13.61 1194 91091562 XP_967054.1 556 2.6e-54 PREDICTED: mRNA turnover protein 4 homolog [Tribolium castaneum]>gi|270000914|gb|EEZ97361.1| hypothetical protein TcasGA2_TC011183 [Tribolium castaneum] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9D0I8 443 1.4e-42 mRNA turnover protein 4 homolog OS=Mus musculus GN=Mrto4 PE=2 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0030529//GO:0005622 intracellular ribonucleoprotein complex//intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.54662 BP_3 368.30 8.46 2391 270004127 EFA00575.1 1563 8.9e-171 hypothetical protein TcasGA2_TC003445 [Tribolium castaneum] -- -- -- -- -- K15691 RFWD3 E3 ubiquitin-protein ligase RFWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K15691 Q8CIK8 580 3.6e-58 E3 ubiquitin-protein ligase RFWD3 OS=Mus musculus GN=Rfwd3 PE=2 SV=1 PF11789//PF12678//PF17123//PF14634//PF00097//PF13639//PF12861//PF01363//PF00400 Zinc-finger of the MIZ type in Nse subunit//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//FYVE zinc finger//WD domain, G-beta repeat GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG1645 RING-finger-containing E3 ubiquitin ligase Cluster-8309.54666 BP_3 165.76 1.85 4617 642918773 XP_008191578.1 4387 0.0e+00 PREDICTED: calpain-D-like isoform X2 [Tribolium castaneum] 194768179 XM_001966155.1 202 1.07363e-98 Drosophila ananassae GF19541 (Dana\GF19541), mRNA K08582 CAPN15 calpain-15 http://www.genome.jp/dbget-bin/www_bget?ko:K08582 P27398 2414 1.5e-270 Calpain-D OS=Drosophila melanogaster GN=sol PE=1 SV=2 PF00641//PF00648 Zn-finger in Ran binding protein and others//Calpain family cysteine protease GO:0006508 proteolysis GO:0004198//GO:0008270 calcium-dependent cysteine-type endopeptidase activity//zinc ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.54668 BP_3 31.83 2.28 966 478250258 ENN70758.1 183 3.8e-11 hypothetical protein YQE_12547, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54669 BP_3 8.00 0.76 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54671 BP_3 19.00 1.82 794 -- -- -- -- -- 642922719 XM_008195074.1 82 9.09101e-33 PREDICTED: Tribolium castaneum LIM domain transcription factor LMO4.1 (LOC661046), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54677 BP_3 251.40 2.68 4815 642933730 XP_008197339.1 4432 0.0e+00 PREDICTED: transmembrane protein 132B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q14DG7 701 6.7e-72 Transmembrane protein 132B OS=Homo sapiens GN=TMEM132B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4789 Uncharacterized conserved protein Cluster-8309.54678 BP_3 27.57 0.55 2702 270009092 EFA05540.1 2929 0.0e+00 hypothetical protein TcasGA2_TC015727 [Tribolium castaneum] 642926476 XM_008193752.1 224 3.68147e-111 PREDICTED: Tribolium castaneum protein suppressor of forked (LOC661644), mRNA K14408 CSTF3, RNA14 cleavage stimulation factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14408 P25991 2026 8.5e-226 Protein suppressor of forked OS=Drosophila melanogaster GN=su(f) PE=1 SV=2 PF09520//PF05843 Type II restriction endonuclease, TdeIII//Suppressor of forked protein (Suf) GO:0006308//GO:0009307//GO:0006397 DNA catabolic process//DNA restriction-modification system//mRNA processing GO:0009036//GO:0003677 Type II site-specific deoxyribonuclease activity//DNA binding GO:0005634//GO:0009359 nucleus//Type II site-specific deoxyribonuclease complex KOG1914 mRNA cleavage and polyadenylation factor I complex, subunit RNA14 Cluster-8309.54679 BP_3 3.00 0.56 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54685 BP_3 40.49 0.67 3222 642935223 XP_008199698.1 2123 1.4e-235 PREDICTED: uncharacterized protein LOC103314735 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58CV6 236 3.7e-18 Kelch domain-containing protein 3 OS=Bos taurus GN=KLHDC3 PE=2 SV=2 PF01344//PF07646//PF01239 Kelch motif//Kelch motif//Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity -- -- -- -- Cluster-8309.54686 BP_3 113.43 0.90 6363 91083069 XP_967587.1 2909 0.0e+00 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q0KI50 1792 2.7e-198 Dystrophin, isoform D OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF14641//PF08115//PF00569//PF04632//PF16473//PF00397//PF04111//PF04977//PF08826//PF11365//PF11802//PF02183//PF02601//PF10473//PF09177 Helix-turn-helix DNA-binding domain of SPT6//SFI toxin family//Zinc finger, ZZ type//Fusaric acid resistance protein family//Domain of unknown function (DUF5051)//WW domain//Autophagy protein Apg6//Septum formation initiator//DMPK coiled coil domain like//Protein of unknown function (DUF3166)//Centromere-associated protein K//Homeobox associated leucine zipper//Exonuclease VII, large subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal GO:0010506//GO:0016310//GO:0048193//GO:0006810//GO:0006468//GO:0009069//GO:0006914//GO:0009405//GO:0007049//GO:0006355//GO:0006308 regulation of autophagy//phosphorylation//Golgi vesicle transport//transport//protein phosphorylation//serine family amino acid metabolic process//autophagy//pathogenesis//cell cycle//regulation of transcription, DNA-templated//DNA catabolic process GO:0008134//GO:0045502//GO:0005524//GO:0004674//GO:0003700//GO:0003676//GO:0005509//GO:0043565//GO:0008270//GO:0005515//GO:0008855//GO:0003677//GO:0042803 transcription factor binding//dynein binding//ATP binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//nucleic acid binding//calcium ion binding//sequence-specific DNA binding//zinc ion binding//protein binding//exodeoxyribonuclease VII activity//DNA binding//protein homodimerization activity GO:0005615//GO:0009318//GO:0005667//GO:0030286//GO:0005886//GO:0005634//GO:0016020//GO:0005576 extracellular space//exodeoxyribonuclease VII complex//transcription factor complex//dynein complex//plasma membrane//nucleus//membrane//extracellular region -- -- Cluster-8309.54687 BP_3 723.26 8.76 4270 91083069 XP_967587.1 2481 5.7e-277 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q7YU29 1702 5.0e-188 Dystrophin, isoform E OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF02183//PF02601//PF04977//PF00569//PF10473//PF01166//PF07716//PF11365//PF11802//PF08826//PF04111//PF00397//PF16473//PF00170//PF08115//PF06005//PF14641 Homeobox associated leucine zipper//Exonuclease VII, large subunit//Septum formation initiator//Zinc finger, ZZ type//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TSC-22/dip/bun family//Basic region leucine zipper//Protein of unknown function (DUF3166)//Centromere-associated protein K//DMPK coiled coil domain like//Autophagy protein Apg6//WW domain//Domain of unknown function (DUF5051)//bZIP transcription factor//SFI toxin family//Protein of unknown function (DUF904)//Helix-turn-helix DNA-binding domain of SPT6 GO:0006355//GO:0007049//GO:0010506//GO:0009405//GO:0006914//GO:0009069//GO:0006468//GO:0043093//GO:0000917//GO:0006308//GO:0016310 regulation of transcription, DNA-templated//cell cycle//regulation of autophagy//pathogenesis//autophagy//serine family amino acid metabolic process//protein phosphorylation//FtsZ-dependent cytokinesis//barrier septum assembly//DNA catabolic process//phosphorylation GO:0008270//GO:0043565//GO:0004674//GO:0003700//GO:0005524//GO:0045502//GO:0008134//GO:0003676//GO:0042803//GO:0005509//GO:0003677//GO:0005515//GO:0008855 zinc ion binding//sequence-specific DNA binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//ATP binding//dynein binding//transcription factor binding//nucleic acid binding//protein homodimerization activity//calcium ion binding//DNA binding//protein binding//exodeoxyribonuclease VII activity GO:0009318//GO:0005737//GO:0005615//GO:0005576//GO:0030286//GO:0005634//GO:0005667 exodeoxyribonuclease VII complex//cytoplasm//extracellular space//extracellular region//dynein complex//nucleus//transcription factor complex -- -- Cluster-8309.54688 BP_3 469.36 5.35 4522 91083069 XP_967587.1 2488 9.3e-278 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q9VDW3 1708 1.1e-188 Dystrophin, isoform B OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF08826//PF11365//PF11802//PF07716//PF01166//PF10473//PF14641//PF06005//PF00170//PF08115//PF00397//PF16473//PF04111//PF02183//PF02601//PF00569//PF04977 DMPK coiled coil domain like//Protein of unknown function (DUF3166)//Centromere-associated protein K//Basic region leucine zipper//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Helix-turn-helix DNA-binding domain of SPT6//Protein of unknown function (DUF904)//bZIP transcription factor//SFI toxin family//WW domain//Domain of unknown function (DUF5051)//Autophagy protein Apg6//Homeobox associated leucine zipper//Exonuclease VII, large subunit//Zinc finger, ZZ type//Septum formation initiator GO:0009069//GO:0006914//GO:0006468//GO:0010506//GO:0009405//GO:0007049//GO:0006355//GO:0016310//GO:0006308//GO:0043093//GO:0000917 serine family amino acid metabolic process//autophagy//protein phosphorylation//regulation of autophagy//pathogenesis//cell cycle//regulation of transcription, DNA-templated//phosphorylation//DNA catabolic process//FtsZ-dependent cytokinesis//barrier septum assembly GO:0045502//GO:0008134//GO:0005524//GO:0003700//GO:0004674//GO:0008270//GO:0043565//GO:0008855//GO:0005515//GO:0003677//GO:0042803//GO:0005509//GO:0003676 dynein binding//transcription factor binding//ATP binding//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity//zinc ion binding//sequence-specific DNA binding//exodeoxyribonuclease VII activity//protein binding//DNA binding//protein homodimerization activity//calcium ion binding//nucleic acid binding GO:0005615//GO:0005737//GO:0009318//GO:0005667//GO:0005634//GO:0030286//GO:0005576 extracellular space//cytoplasm//exodeoxyribonuclease VII complex//transcription factor complex//nucleus//dynein complex//extracellular region -- -- Cluster-8309.54691 BP_3 141.99 2.31 3252 642927423 XP_008195266.1 1097 1.3e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum]>gi|642927425|ref|XP_008195267.1| PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF16622 Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.54693 BP_3 10.46 0.39 1590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54694 BP_3 1122.84 18.74 3180 642926208 XP_008194830.1 1578 2.2e-172 PREDICTED: uncharacterized protein LOC662086 isoform X2 [Tribolium castaneum] 347967374 XM_003436013.1 97 1.72407e-40 Anopheles gambiae str. PEST AGAP002199-PB (AgaP_AGAP002199) mRNA, complete cds -- -- -- -- -- -- -- -- PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54695 BP_3 3091.16 40.79 3944 270009021 EFA05469.1 2230 6.7e-248 hypothetical protein TcasGA2_TC015652 [Tribolium castaneum] 347967374 XM_003436013.1 97 2.14302e-40 Anopheles gambiae str. PEST AGAP002199-PB (AgaP_AGAP002199) mRNA, complete cds -- -- -- -- -- -- -- -- PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54696 BP_3 166.00 9.81 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54697 BP_3 13.73 4.14 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54699 BP_3 2016.18 117.61 1118 189242304 XP_001808377.1 640 4.5e-64 PREDICTED: uncharacterized protein LOC100141613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54702 BP_3 322.14 4.31 3897 642913983 XP_008201501.1 2263 9.9e-252 PREDICTED: probable ATP-dependent RNA helicase DDX56 [Tribolium castaneum]>gi|270002128|gb|EEZ98575.1| hypothetical protein TcasGA2_TC001089 [Tribolium castaneum] 642913982 XM_008203279.1 342 1.35214e-176 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX56 (LOC655034), mRNA K14810 DDX56, DBP9 ATP-dependent RNA helicase DDX56/DBP9 http://www.genome.jp/dbget-bin/www_bget?ko:K14810 Q3SZ40 1378 1.7e-150 Probable ATP-dependent RNA helicase DDX56 OS=Bos taurus GN=DDX56 PE=2 SV=1 PF04851//PF01484//PF02732//PF07652//PF00270 Type III restriction enzyme, res subunit//Nematode cuticle collagen N-terminal domain//ERCC4 domain//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0019079 viral genome replication GO:0003676//GO:0004518//GO:0003677//GO:0016787//GO:0005524//GO:0042302//GO:0008026 nucleic acid binding//nuclease activity//DNA binding//hydrolase activity//ATP binding//structural constituent of cuticle//ATP-dependent helicase activity -- -- KOG0346 RNA helicase Cluster-8309.54703 BP_3 725.27 19.60 2075 642938784 XP_008199885.1 1060 1.6e-112 PREDICTED: meiosis-specific nuclear structural protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBA8 579 4.0e-58 Meiosis-specific nuclear structural protein 1 OS=Danio rerio GN=mns1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54705 BP_3 1.00 3.30 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54708 BP_3 71.14 9.65 647 642922009 XP_008192983.1 180 5.6e-11 PREDICTED: timeless isoform X1 [Tribolium castaneum]>gi|270008196|gb|EFA04644.1| timeless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54709 BP_3 3.00 1.53 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54712 BP_3 163.30 1.07 7642 642932112 XP_008196860.1 3146 0.0e+00 PREDICTED: ABC transporter G family member 14 isoform X1 [Tribolium castaneum] 642932111 XM_008198638.1 779 0 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X1, mRNA -- -- -- -- Q6WV17 1239 4.4e-134 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 PF01637//PF05418//PF00005//PF03193//PF00910//PF10662//PF01061//PF01926//PF13304//PF00004//PF00437 Archaeal ATPase//Apovitellenin I (Apo-VLDL-II)//ABC transporter//Protein of unknown function, DUF258//RNA helicase//Ethanolamine utilisation - propanediol utilisation//ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006576//GO:0006629//GO:0006810 cellular biogenic amine metabolic process//lipid metabolic process//transport GO:0003723//GO:0005524//GO:0003924//GO:0004857//GO:0016887//GO:0005525//GO:0003724 RNA binding//ATP binding//GTPase activity//enzyme inhibitor activity//ATPase activity//GTP binding//RNA helicase activity GO:0016020//GO:0042627 membrane//chylomicron KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.54713 BP_3 22.07 1.26 1135 642932395 XP_008197093.1 418 2.5e-38 PREDICTED: leucine-rich repeat-containing protein 70-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESY6 127 5.7e-06 Leucine-rich repeat neuronal protein 3 OS=Rattus norvegicus GN=Lrrn3 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.54714 BP_3 128.01 1.36 4842 642912709 XP_008200970.1 3371 0.0e+00 PREDICTED: PDZ domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NEN9 534 1.6e-52 PDZ domain-containing protein 8 OS=Homo sapiens GN=PDZD8 PE=1 SV=1 PF00130//PF04689//PF01484//PF00595//PF13180 Phorbol esters/diacylglycerol binding domain (C1 domain)//DNA binding protein S1FA//Nematode cuticle collagen N-terminal domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0005515//GO:0042302 DNA binding//protein binding//structural constituent of cuticle GO:0005634 nucleus KOG3532 Predicted protein kinase Cluster-8309.54717 BP_3 9.66 0.53 1164 91085247 XP_973234.1 928 1.9e-97 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 205 5.68896e-101 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 706 4.2e-73 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF01134//PF04437//PF04091 Glucose inhibited division protein A//RINT-1 / TIP-1 family//Exocyst complex subunit Sec15-like GO:0006904//GO:0008033//GO:0048193 vesicle docking involved in exocytosis//tRNA processing//Golgi vesicle transport GO:0050660 flavin adenine dinucleotide binding GO:0000145//GO:0005783 exocyst//endoplasmic reticulum KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.54718 BP_3 25.85 1.10 1422 642925526 XP_008194587.1 238 2.3e-17 PREDICTED: probable low-specificity L-threonine aldolase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54719 BP_3 29.00 0.88 1886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54723 BP_3 8.74 1.49 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54725 BP_3 178.34 5.15 1961 817081624 XP_012263337.1 1695 3.6e-186 PREDICTED: protein brunelleschi [Athalia rosae]>gi|817081626|ref|XP_012263338.1| PREDICTED: protein brunelleschi [Athalia rosae] -- -- -- -- -- -- -- -- -- Q9VIL0 1112 6.0e-120 Protein brunelleschi OS=Drosophila melanogaster GN=bru PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54729 BP_3 1343.86 19.93 3542 759041178 XP_011329400.1 2003 1.3e-221 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Cerapachys biroi] 195434173 XM_002065042.1 152 5.12333e-71 Drosophila willistoni GK15268 (Dwil\GK15268), mRNA K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 1145 1.6e-123 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF01340//PF03602//PF05185//PF01209//PF02390//PF08241//PF01728//PF01135//PF05175//PF02065//PF00517//PF16499 Met Apo-repressor, MetJ//Conserved hypothetical protein 95//PRMT5 arginine-N-methyltransferase//ubiE/COQ5 methyltransferase family//Putative methyltransferase//Methyltransferase domain//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Melibiase//Retroviral envelope protein//Alpha galactosidase A GO:0031167//GO:0001575//GO:0006464//GO:0046486//GO:0008033//GO:0005975//GO:0006355//GO:0006012//GO:0008152//GO:0046500//GO:0006555//GO:0032259//GO:0006400//GO:0009451//GO:0006479 rRNA methylation//globoside metabolic process//cellular protein modification process//glycerolipid metabolic process//tRNA processing//carbohydrate metabolic process//regulation of transcription, DNA-templated//galactose metabolic process//metabolic process//S-adenosylmethionine metabolic process//methionine metabolic process//methylation//tRNA modification//RNA modification//protein methylation GO:0005198//GO:0004553//GO:0004557//GO:0003700//GO:0008168//GO:0004719//GO:0008176 structural molecule activity//hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-galactosidase activity//transcription factor activity, sequence-specific DNA binding//methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005667//GO:0019031 transcription factor complex//viral envelope KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.54730 BP_3 122.94 1.73 3726 642913416 XP_008201002.1 2429 5.3e-271 PREDICTED: supernumerary limbs isoform X2 [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 5.6e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF12937//PF12125//PF00400//PF00646//PF15324 F-box-like//D domain of beta-TrCP//WD domain, G-beta repeat//F-box domain//Hedgehog signalling target GO:0007224 smoothened signaling pathway GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.54732 BP_3 30.24 0.31 4933 642927980 XP_008195470.1 951 1.7e-99 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AKG8 300 2.2e-25 Focadhesin OS=Mus musculus GN=Focad PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54735 BP_3 19.02 0.51 2090 478253248 ENN73619.1 686 3.9e-69 hypothetical protein YQE_09866, partial [Dendroctonus ponderosae] -- -- -- -- -- K15277 SLC35B3, PAPST2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 http://www.genome.jp/dbget-bin/www_bget?ko:K15277 Q7Q5D4 522 1.7e-51 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Anopheles gambiae GN=Papst2 PE=3 SV=4 PF08449//PF00892 UAA transporter family//EamA-like transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1582 UDP-galactose transporter related protein Cluster-8309.54739 BP_3 185.94 6.49 1673 642939750 XP_008195710.1 1346 9.1e-146 PREDICTED: protein FAM43A, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2R8 243 3.0e-19 Protein FAM43A OS=Homo sapiens GN=FAM43A PE=2 SV=2 PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4448 Uncharacterized conserved protein, contains phosphotyrosine interaction (PI) domain Cluster-8309.54740 BP_3 53.35 0.81 3449 642928502 XP_008193817.1 290 5.3e-23 PREDICTED: ninjurin-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZG7 165 6.8e-10 Ninjurin-2 OS=Homo sapiens GN=NINJ2 PE=1 SV=1 PF04923 Ninjurin GO:0042246//GO:0007155 tissue regeneration//cell adhesion -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54741 BP_3 45.40 0.37 6276 642913543 XP_971895.2 587 3.5e-57 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 9.5e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF12678//PF00643//PF14634//PF06506//PF00097//PF01155//PF01363//PF06003//PF13639//PF16685 RING-H2 zinc finger//B-box zinc finger//zinc-RING finger domain//Propionate catabolism activator//Zinc finger, C3HC4 type (RING finger)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//FYVE zinc finger//Survival motor neuron protein (SMN)//Ring finger domain//zinc RING finger of MSL2 GO:0006397//GO:0000160//GO:0006464 mRNA processing//phosphorelay signal transduction system//cellular protein modification process GO:0003677//GO:0005524//GO:0003723//GO:0005515//GO:0061630//GO:0016151//GO:0000156//GO:0008270//GO:0046872 DNA binding//ATP binding//RNA binding//protein binding//ubiquitin protein ligase activity//nickel cation binding//phosphorelay response regulator activity//zinc ion binding//metal ion binding GO:0005634//GO:0005622//GO:0005737 nucleus//intracellular//cytoplasm -- -- Cluster-8309.54742 BP_3 650.63 25.57 1518 546683069 ERL92930.1 479 2.8e-45 hypothetical protein D910_10235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9JL89 209 2.4e-15 Ninjurin-2 OS=Mus musculus GN=Ninj2 PE=2 SV=1 PF04923//PF01545//PF10192//PF02990 Ninjurin//Cation efflux family//Rhodopsin-like GPCR transmembrane domain//Endomembrane protein 70 GO:0007155//GO:0007186//GO:0006812//GO:0019236//GO:0055085//GO:0042246 cell adhesion//G-protein coupled receptor signaling pathway//cation transport//response to pheromone//transmembrane transport//tissue regeneration GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.54743 BP_3 719.13 6.35 5748 642913543 XP_971895.2 1130 3.5e-120 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 A9CPT4 170 3.0e-10 Tudor domain-containing protein 1 OS=Oryzias latipes GN=tdrd1 PE=2 SV=1 PF00097//PF06506//PF14634//PF00643//PF12678//PF01155//PF06003//PF01363//PF02736//PF16685//PF13639 Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator//zinc-RING finger domain//B-box zinc finger//RING-H2 zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Survival motor neuron protein (SMN)//FYVE zinc finger//Myosin N-terminal SH3-like domain//zinc RING finger of MSL2//Ring finger domain GO:0006397//GO:0000160//GO:0006464 mRNA processing//phosphorelay signal transduction system//cellular protein modification process GO:0003774//GO:0046872//GO:0003677//GO:0003723//GO:0005515//GO:0061630//GO:0016151//GO:0000156//GO:0008270//GO:0005524 motor activity//metal ion binding//DNA binding//RNA binding//protein binding//ubiquitin protein ligase activity//nickel cation binding//phosphorelay response regulator activity//zinc ion binding//ATP binding GO:0005634//GO:0005622//GO:0005737//GO:0016459 nucleus//intracellular//cytoplasm//myosin complex -- -- Cluster-8309.54744 BP_3 430.58 4.36 5050 642913543 XP_971895.2 1210 1.6e-129 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 7.6e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF06003//PF00643//PF14634//PF02736//PF00097//PF06506 Survival motor neuron protein (SMN)//B-box zinc finger//zinc-RING finger domain//Myosin N-terminal SH3-like domain//Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator GO:0006397//GO:0000160 mRNA processing//phosphorelay signal transduction system GO:0005524//GO:0003723//GO:0003677//GO:0005515//GO:0008270//GO:0000156//GO:0003774//GO:0046872 ATP binding//RNA binding//DNA binding//protein binding//zinc ion binding//phosphorelay response regulator activity//motor activity//metal ion binding GO:0005634//GO:0016459//GO:0005622//GO:0005737 nucleus//myosin complex//intracellular//cytoplasm -- -- Cluster-8309.54745 BP_3 35.21 0.32 5655 642913543 XP_971895.2 672 4.4e-67 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 8.5e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF14634//PF00643//PF06003//PF02736//PF00097//PF06506 zinc-RING finger domain//B-box zinc finger//Survival motor neuron protein (SMN)//Myosin N-terminal SH3-like domain//Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator GO:0000160//GO:0006397 phosphorelay signal transduction system//mRNA processing GO:0046872//GO:0003774//GO:0000156//GO:0008270//GO:0005515//GO:0003677//GO:0003723//GO:0005524 metal ion binding//motor activity//phosphorelay response regulator activity//zinc ion binding//protein binding//DNA binding//RNA binding//ATP binding GO:0005737//GO:0005622//GO:0016459//GO:0005634 cytoplasm//intracellular//myosin complex//nucleus -- -- Cluster-8309.54747 BP_3 224.33 2.10 5440 642913543 XP_971895.2 672 4.2e-67 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 8.2e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF06003//PF00643//PF14634//PF02736//PF00097//PF06506 Survival motor neuron protein (SMN)//B-box zinc finger//zinc-RING finger domain//Myosin N-terminal SH3-like domain//Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator GO:0000160//GO:0006397 phosphorelay signal transduction system//mRNA processing GO:0005515//GO:0003723//GO:0005524//GO:0003677//GO:0046872//GO:0008270//GO:0000156//GO:0003774 protein binding//RNA binding//ATP binding//DNA binding//metal ion binding//zinc ion binding//phosphorelay response regulator activity//motor activity GO:0005634//GO:0016459//GO:0005737//GO:0005622 nucleus//myosin complex//cytoplasm//intracellular -- -- Cluster-8309.54748 BP_3 21.87 1.51 989 642931088 XP_008196205.1 156 5.2e-08 PREDICTED: partner of Y14 and mago [Tribolium castaneum]>gi|270011886|gb|EFA08334.1| hypothetical protein TcasGA2_TC005977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07966//PF09268//PF09317 A1 Propeptide//Clathrin, heavy-chain linker//Domain of unknown function (DUF1974) GO:0006886//GO:0016192//GO:0055114//GO:0033539//GO:0006118//GO:0006508 intracellular protein transport//vesicle-mediated transport//oxidation-reduction process//fatty acid beta-oxidation using acyl-CoA dehydrogenase//obsolete electron transport//proteolysis GO:0005198//GO:0003995//GO:0004190 structural molecule activity//acyl-CoA dehydrogenase activity//aspartic-type endopeptidase activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle -- -- Cluster-8309.54749 BP_3 15.00 4.07 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54753 BP_3 54.26 0.34 8022 91088309 XP_969421.1 1779 2.7e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 808 4.4e-84 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF02254//PF05199//PF07992//PF07307//PF05834//PF00732//PF01266 TrkA-N domain//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0055114//GO:0016117//GO:0009234//GO:0006813 oxidation-reduction process//carotenoid biosynthetic process//menaquinone biosynthetic process//potassium ion transport GO:0050660//GO:0016491//GO:0016614//GO:0016705 flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.54754 BP_3 82.85 0.77 5447 242008211 XP_002424904.1 2464 6.8e-275 zinc finger protein, putative [Pediculus humanus corporis]>gi|212508484|gb|EEB12166.1| zinc finger protein, putative [Pediculus humanus corporis] 817192597 XM_012416318.1 430 0 PREDICTED: Orussus abietinus zinc finger protein 665-like (LOC105695064), transcript variant X6, mRNA -- -- -- -- P51523 1365 7.6e-149 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13912//PF06467//PF00096//PF13465 C2H2-type zinc finger//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005488//GO:0008270 metal ion binding//binding//zinc ion binding -- -- -- -- Cluster-8309.54757 BP_3 7.26 0.89 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54764 BP_3 93.90 1.41 3509 478254043 ENN74335.1 2208 2.1e-245 hypothetical protein YQE_09305, partial [Dendroctonus ponderosae] 462310547 APGK01047286.1 86 2.48109e-34 Dendroctonus ponderosae Seq01047296, whole genome shotgun sequence K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 Q5ZKV8 1495 4.1e-164 Kinesin-like protein KIF2A OS=Gallus gallus GN=KIF2A PE=2 SV=2 PF04889//PF00225 Cwf15/Cwc15 cell cycle control protein//Kinesin motor domain GO:0000398//GO:0007017//GO:0007018 mRNA splicing, via spliceosome//microtubule-based process//microtubule-based movement GO:0008017//GO:0003777//GO:0005524 microtubule binding//microtubule motor activity//ATP binding GO:0005681//GO:0005874//GO:0045298 spliceosomal complex//microtubule//tubulin complex KOG0246 Kinesin-like protein Cluster-8309.54767 BP_3 279.22 12.06 1408 642935018 XP_968403.2 1217 7.0e-131 PREDICTED: WD repeat-containing protein 91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZLL7 576 6.1e-58 WD repeat-containing protein 91 OS=Gallus gallus GN=WDR91 PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- KOG1333 Uncharacterized conserved protein Cluster-8309.54772 BP_3 37.67 0.55 3565 478257833 ENN77976.1 706 3.2e-71 hypothetical protein YQE_05652, partial [Dendroctonus ponderosae] -- -- -- -- -- K18665 NUDT8 nudix motif 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18665 Q8WV74 264 2.3e-21 Nucleoside diphosphate-linked moiety X motif 8, mitochondrial OS=Homo sapiens GN=NUDT8 PE=2 SV=2 PF00293//PF00050//PF07648 NUDIX domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0016787//GO:0005515 hydrolase activity//protein binding -- -- KOG3069 Peroxisomal NUDIX hydrolase Cluster-8309.54776 BP_3 65.62 0.40 8145 270015299 EFA11747.1 1766 8.8e-194 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2VWP9 492 1.9e-47 Protogenin OS=Rattus norvegicus GN=Prtg PE=2 SV=1 PF16656//PF00041//PF13895 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.5478 BP_3 26.00 1.52 1117 861580033 KMQ82110.1 158 3.5e-08 n1r p28-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- Q91FL1 203 8.6e-15 Putative KilA-N domain-containing protein 313L OS=Invertebrate iridescent virus 6 GN=IIV6-313L PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54781 BP_3 182.69 2.67 3590 642929233 XP_008195746.1 1038 1.0e-109 PREDICTED: claspin homolog [Tribolium castaneum]>gi|270009673|gb|EFA06121.1| hypothetical protein TcasGA2_TC008964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRB5 380 8.3e-35 Claspin homolog OS=Drosophila melanogaster GN=CG32251 PE=1 SV=1 PF07827 KNTase C-terminal domain GO:0046677 response to antibiotic GO:0016779 nucleotidyltransferase activity -- -- KOG4156 Claspin, protein mediating phosphorylation and activation of Chk1 protein kinase in the DNA replication checkpoint response Cluster-8309.54784 BP_3 5.48 0.32 1109 768430787 XP_011556635.1 855 5.2e-89 PREDICTED: DNA-(apurinic or apyrimidinic site) lyase-like [Plutella xylostella] -- -- -- -- -- K10771 APEX1 AP endonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10771 P27864 725 2.5e-75 Recombination repair protein 1 OS=Drosophila melanogaster GN=Rrp1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes Cluster-8309.54787 BP_3 7.00 0.40 1130 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5479 BP_3 8.00 0.83 759 270001407 EEZ97854.1 267 5.4e-21 hypothetical protein TcasGA2_TC000226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54793 BP_3 4.00 1.19 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54794 BP_3 18.28 0.63 1692 546673463 ERL85061.1 595 1.1e-58 hypothetical protein D910_02484, partial [Dendroctonus ponderosae] 157136696 XM_001656830.1 41 1.22676e-09 Aedes aegypti AAEL013617-RA partial mRNA -- -- -- -- P15882 368 9.6e-34 N-chimaerin OS=Homo sapiens GN=CHN1 PE=1 SV=3 PF00620//PF04434 RhoGAP domain//SWIM zinc finger GO:0007165 signal transduction GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.54798 BP_3 54.75 2.36 1408 642935798 XP_008198179.1 407 5.8e-37 PREDICTED: CD63 antigen [Tribolium castaneum]>gi|270013280|gb|EFA09728.1| hypothetical protein TcasGA2_TC011861 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KHY8 171 5.6e-11 Leukocyte antigen CD37 OS=Bos taurus GN=CD37 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54801 BP_3 40.00 0.75 2870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54803 BP_3 65.04 0.83 4089 642911033 XP_008193517.1 2518 2.8e-281 PREDICTED: small conductance calcium-activated potassium channel protein [Tribolium castaneum] 642911032 XM_008195295.1 711 0 PREDICTED: Tribolium castaneum small conductance calcium-activated potassium channel protein (LOC657962), mRNA K05325 KCNNN potassium intermediate/small conductance calcium-activated channel subfamily N, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05325 Q7KVW5 2111 1.8e-235 Small conductance calcium-activated potassium channel protein OS=Drosophila melanogaster GN=SK PE=2 SV=2 PF03119//PF00520//PF02888//PF01544//PF03530//PF01407 NAD-dependent DNA ligase C4 zinc finger domain//Ion transport protein//Calmodulin binding domain//CorA-like Mg2+ transporter protein//Calcium-activated SK potassium channel//Geminivirus AL3 protein GO:0030001//GO:0055085//GO:0016032//GO:0006813//GO:0006281//GO:0006260//GO:0006811 metal ion transport//transmembrane transport//viral process//potassium ion transport//DNA repair//DNA replication//ion transport GO:0005516//GO:0003911//GO:0016286//GO:0015269//GO:0005216//GO:0046873 calmodulin binding//DNA ligase (NAD+) activity//small conductance calcium-activated potassium channel activity//calcium-activated potassium channel activity//ion channel activity//metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3684 Ca2+-activated K+ channel proteins (intermediate/small conductance classes) Cluster-8309.54804 BP_3 224.60 2.68 4336 270012867 EFA09315.1 1048 8.5e-111 hypothetical protein TcasGA2_TC030748 [Tribolium castaneum] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 532 2.4e-52 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 PF04420 CHD5-like protein GO:0071816 tail-anchored membrane protein insertion into ER membrane -- -- -- -- KOG2687 Spindle pole body protein, contains UNC-84 domain Cluster-8309.54808 BP_3 46.25 3.53 923 728418413 AIY68368.1 345 5.9e-30 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5481 BP_3 2.42 0.41 580 642931814 XP_008196744.1 574 1.0e-56 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 431 1.6e-41 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.54812 BP_3 2.00 0.83 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54813 BP_3 26.55 0.89 1735 332375126 AEE62704.1 467 7.9e-44 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10739 RFA2, RPA2 replication factor A2 http://www.genome.jp/dbget-bin/www_bget?ko:K10739 Q63528 194 1.5e-13 Replication protein A 32 kDa subunit OS=Rattus norvegicus GN=Rpa2 PE=2 SV=2 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG3108 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit Cluster-8309.5482 BP_3 78.00 2.46 1819 642931423 XP_008196576.1 1094 1.6e-116 PREDICTED: potassium channel subfamily K member 18 [Tribolium castaneum] 505771126 XM_004601051.1 43 1.02103e-10 PREDICTED: Sorex araneus potassium channel, two pore domain subfamily K, member 6 (KCNK6), partial mRNA -- -- -- -- Q18120 184 2.2e-12 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF07425//PF04973//PF01007//PF00520 Pardaxin//Nicotinamide mononucleotide transporter//Inward rectifier potassium channel//Ion transport protein GO:0006813//GO:0055085//GO:0006811//GO:0034258 potassium ion transport//transmembrane transport//ion transport//nicotinamide riboside transport GO:0005242//GO:0034257//GO:0005216 inward rectifier potassium channel activity//nicotinamide riboside transmembrane transporter activity//ion channel activity GO:0016021//GO:0008076//GO:0005576//GO:0016020 integral component of membrane//voltage-gated potassium channel complex//extracellular region//membrane KOG1418 Tandem pore domain K+ channel Cluster-8309.54823 BP_3 1035.99 15.86 3441 189236229 XP_001812942.1 1795 1.6e-197 PREDICTED: uncharacterized protein LOC100141771 [Tribolium castaneum] 642919319 XM_001812890.2 119 1.10016e-52 PREDICTED: Tribolium castaneum uncharacterized LOC100141771 (LOC100141771), mRNA -- -- -- -- Q9GNL3 175 4.7e-11 Transmembrane protein fend OS=Drosophila melanogaster GN=fend PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54824 BP_3 80.01 2.10 2125 189236229 XP_001812942.1 1723 2.2e-189 PREDICTED: uncharacterized protein LOC100141771 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GNL3 175 2.9e-11 Transmembrane protein fend OS=Drosophila melanogaster GN=fend PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54825 BP_3 23.70 0.36 3450 189235122 XP_001811652.1 2006 5.5e-222 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 422 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1600 2.7e-176 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF15048//PF01496//PF00856 Organic solute transporter subunit beta protein//V-type ATPase 116kDa subunit family//SET domain GO:0006810//GO:0015721//GO:0015991//GO:0015992 transport//bile acid and bile salt transport//ATP hydrolysis coupled proton transport//proton transport GO:0046982//GO:0005515//GO:0005215//GO:0003682//GO:0015078 protein heterodimerization activity//protein binding//transporter activity//chromatin binding//hydrogen ion transmembrane transporter activity GO:0005886//GO:0000785//GO:0033179 plasma membrane//chromatin//proton-transporting V-type ATPase, V0 domain KOG1079 Transcriptional repressor EZH1 Cluster-8309.54827 BP_3 42.10 4.52 741 642019431 CDQ95405.1 351 9.6e-31 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- Q04202 161 4.2e-10 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 PF12844//PF01498//PF01047//PF08281//PF00292//PF00196//PF01325//PF13463//PF02796//PF04545//PF06056 Helix-turn-helix domain//Transposase//MarR family//Sigma-70, region 4//'Paired box' domain//Bacterial regulatory proteins, luxR family//Iron dependent repressor, N-terminal DNA binding domain//Winged helix DNA-binding domain//Helix-turn-helix domain of resolvase//Sigma-70, region 4//Putative ATPase subunit of terminase (gpP-like) GO:0019069//GO:0006352//GO:0015074//GO:0006355//GO:0006310//GO:0006313 viral capsid assembly//DNA-templated transcription, initiation//DNA integration//regulation of transcription, DNA-templated//DNA recombination//transposition, DNA-mediated GO:0003700//GO:0043565//GO:0016987//GO:0000150//GO:0005524//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//sigma factor activity//recombinase activity//ATP binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.54828 BP_3 102.40 4.87 1305 270016600 EFA13046.1 231 1.4e-16 hypothetical protein TcasGA2_TC010748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01283 Ribosomal protein S26e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.54829 BP_3 17.90 1.99 725 642019431 CDQ95405.1 363 3.8e-32 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- Q04202 162 3.2e-10 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 PF12844//PF01047//PF01498//PF08281//PF00196//PF01325//PF00292//PF06056//PF02796//PF04545 Helix-turn-helix domain//MarR family//Transposase//Sigma-70, region 4//Bacterial regulatory proteins, luxR family//Iron dependent repressor, N-terminal DNA binding domain//'Paired box' domain//Putative ATPase subunit of terminase (gpP-like)//Helix-turn-helix domain of resolvase//Sigma-70, region 4 GO:0006355//GO:0006310//GO:0015074//GO:0019069//GO:0006352//GO:0006313 regulation of transcription, DNA-templated//DNA recombination//DNA integration//viral capsid assembly//DNA-templated transcription, initiation//transposition, DNA-mediated GO:0016987//GO:0043565//GO:0003700//GO:0003677//GO:0005524//GO:0000150 sigma factor activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//ATP binding//recombinase activity GO:0005667 transcription factor complex -- -- Cluster-8309.54831 BP_3 112.15 2.65 2328 546680809 ERL91015.1 1217 1.2e-130 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 1134 2.0e-122 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.54834 BP_3 104.99 1.19 4535 642912652 XP_008200949.1 1269 2.1e-136 PREDICTED: tubulin epsilon chain [Tribolium castaneum] 642912650 XM_963240.2 181 4.9756e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K10391 TUBE tubulin epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K10391 Q9D6T1 783 1.9e-81 Tubulin epsilon chain OS=Mus musculus GN=Tube1 PE=2 SV=1 PF04632//PF16326//PF04111//PF05531//PF01920//PF04871//PF03357//PF00091//PF00462//PF07544 Fusaric acid resistance protein family//ABC transporter C-terminal domain//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein//Prefoldin subunit//Uso1 / p115 like vesicle tethering protein, C terminal region//Snf7//Tubulin/FtsZ family, GTPase domain//Glutaredoxin//RNA polymerase II transcription mediator complex subunit 9 GO:0007034//GO:0015031//GO:0006357//GO:0006118//GO:0006914//GO:0006886//GO:0006810//GO:0045454//GO:0006457 vacuolar transport//protein transport//regulation of transcription from RNA polymerase II promoter//obsolete electron transport//autophagy//intracellular protein transport//transport//cell redox homeostasis//protein folding GO:0051082//GO:0008565//GO:0003924//GO:0009055//GO:0015035//GO:0001104//GO:0003677 unfolded protein binding//protein transporter activity//GTPase activity//electron carrier activity//protein disulfide oxidoreductase activity//RNA polymerase II transcription cofactor activity//DNA binding GO:0005737//GO:0016272//GO:0019028//GO:0016020//GO:0016592//GO:0005886 cytoplasm//prefoldin complex//viral capsid//membrane//mediator complex//plasma membrane KOG1655 Protein involved in vacuolar protein sorting Cluster-8309.54835 BP_3 40.75 1.13 2025 642920398 XP_008192330.1 189 1.6e-11 PREDICTED: uncharacterized protein LOC103312722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02703 Early E1A protein GO:0019048//GO:0006355 modulation by virus of host morphology or physiology//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.54837 BP_3 24.84 0.66 2119 478256893 ENN77062.1 359 3.2e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 3.3e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF00096//PF13465//PF07975//PF13912//PF05485 Zinc finger, C2H2 type//Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//THAP domain GO:0006281 DNA repair GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.54842 BP_3 36.39 2.20 1090 672017838 XP_008773853.1 392 2.5e-35 PREDICTED: zinc finger protein 431-like isoform X1 [Rattus norvegicus] -- -- -- -- -- -- -- -- -- P51522 368 6.2e-34 Zinc finger protein 83 OS=Homo sapiens GN=ZNF83 PE=2 SV=3 PF13912//PF01428//PF00096//PF13465 C2H2-type zinc finger//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.54848 BP_3 1.00 6.78 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54849 BP_3 587.00 28.51 1284 91079316 XP_967727.1 1251 7.2e-135 PREDICTED: 28S ribosomal protein S35, mitochondrial [Tribolium castaneum]>gi|270004335|gb|EFA00783.1| hypothetical protein TcasGA2_TC003669 [Tribolium castaneum] 195377909 XM_002047694.1 38 4.30219e-08 Drosophila virilis GJ13595 (Dvir\GJ13595), mRNA K17413 MRPS35 small subunit ribosomal protein S35 http://www.genome.jp/dbget-bin/www_bget?ko:K17413 Q2YDF6 779 1.6e-81 28S ribosomal protein S35, mitochondrial OS=Bos taurus GN=MRPS35 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3933 Mitochondrial ribosomal protein S28 Cluster-8309.54855 BP_3 293.17 3.46 4373 91082575 XP_966727.1 790 7.0e-81 PREDICTED: bifunctional arginine demethylase and lysyl-hydroxylase PSR isoform X1 [Tribolium castaneum] -- -- -- -- -- K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q6PFM0 581 5.0e-58 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Danio rerio GN=jmjd6 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain Cluster-8309.54856 BP_3 327.98 6.48 2730 91090155 XP_972292.1 566 4.1e-55 PREDICTED: uncharacterized protein LOC661009 [Tribolium castaneum]>gi|270013490|gb|EFA09938.1| hypothetical protein TcasGA2_TC012091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284//PF05823 Membrane-associating domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1) -- -- GO:0008289 lipid binding GO:0016020 membrane -- -- Cluster-8309.54863 BP_3 29.10 1.04 1635 478255161 ENN75390.1 736 4.8e-75 hypothetical protein YQE_07942, partial [Dendroctonus ponderosae] -- -- -- -- -- K15262 BCP1, BCCIP protein BCP1 http://www.genome.jp/dbget-bin/www_bget?ko:K15262 Q9VFR0 485 2.5e-47 Protein BCCIP homolog OS=Drosophila melanogaster GN=CG9286 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3034 Isoamyl acetate-hydrolyzing esterase and related enzymes Cluster-8309.54865 BP_3 194.21 1.86 5319 642919785 XP_008192065.1 3568 0.0e+00 PREDICTED: kinesin-like protein CG14535 isoform X2 [Tribolium castaneum] 759038090 XM_011353258.1 51 1.07947e-14 PREDICTED: Cerapachys biroi kinesin-like protein CG14535 (LOC105287618), mRNA K10404 KIF26 kinesin family member 26 http://www.genome.jp/dbget-bin/www_bget?ko:K10404 Q7TNC6 924 1.0e-97 Kinesin-like protein KIF26B OS=Mus musculus GN=Kif26b PE=1 SV=3 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.54866 BP_3 413.00 14.53 1662 91087667 XP_973701.1 687 2.3e-69 PREDICTED: deoxyuridine 5'-triphosphate nucleotidohydrolase [Tribolium castaneum]>gi|270009414|gb|EFA05862.1| hypothetical protein TcasGA2_TC008662 [Tribolium castaneum] -- -- -- -- -- K01520 dut, DUT dUTP pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01520 P33316 503 2.1e-49 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens GN=DUT PE=1 SV=4 PF00692 dUTPase GO:0006206//GO:0046080 pyrimidine nucleobase metabolic process//dUTP metabolic process GO:0016787//GO:0004170 hydrolase activity//dUTP diphosphatase activity -- -- KOG3370 dUTPase Cluster-8309.54868 BP_3 1.00 3.39 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54869 BP_3 12.00 1.48 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06733//PF08395 DEAD_2//7tm Chemosensory receptor GO:0050909 sensory perception of taste GO:0005524//GO:0003677//GO:0004003 ATP binding//DNA binding//ATP-dependent DNA helicase activity GO:0005657//GO:0016021 replication fork//integral component of membrane -- -- Cluster-8309.54871 BP_3 3.00 1.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54872 BP_3 3.76 0.43 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54873 BP_3 16.00 5.40 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54874 BP_3 294.00 8.10 2042 642932314 XP_008197061.1 1608 4.6e-176 PREDICTED: ankyrin repeat and SAM domain-containing protein 4B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80T11 515 1.0e-50 Usher syndrome type-1G protein homolog OS=Mus musculus GN=Ush1g PE=1 SV=1 PF13606//PF01920//PF00536//PF10186//PF09128//PF07647//PF00023//PF14721 Ankyrin repeat//Prefoldin subunit//SAM domain (Sterile alpha motif)//Vacuolar sorting 38 and autophagy-related subunit 14//Regulator of G protein signalling-like domain//SAM domain (Sterile alpha motif)//Ankyrin repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term GO:0006457//GO:0043087//GO:0010508 protein folding//regulation of GTPase activity//positive regulation of autophagy GO:0046983//GO:0005515//GO:0051082//GO:0005089 protein dimerization activity//protein binding//unfolded protein binding//Rho guanyl-nucleotide exchange factor activity GO:0016272//GO:0005737 prefoldin complex//cytoplasm -- -- Cluster-8309.54875 BP_3 70.05 3.07 1393 728416984 AIY68330.1 1146 1.2e-122 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 P35502 533 5.8e-53 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06638//PF07859//PF00326 Strabismus protein//alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0007275//GO:0006508 metabolic process//multicellular organismal development//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity GO:0016021 integral component of membrane -- -- Cluster-8309.54877 BP_3 21.91 0.72 1761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54879 BP_3 8.00 1.04 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54881 BP_3 591.39 6.37 4769 642923667 XP_008193834.1 4031 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15439 2431 1.6e-272 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF03193//PF00005//PF13304//PF01926//PF05972//PF00664//PF00437 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//APC 15 residue motif//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0006810//GO:0055085//GO:0016055 transport//transmembrane transport//Wnt signaling pathway GO:0042626//GO:0005525//GO:0008013//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//beta-catenin binding//ATPase activity//GTPase activity//ATP binding GO:0016342//GO:0016021 catenin complex//integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.54882 BP_3 116.08 2.39 2632 642923667 XP_008193834.1 2046 9.7e-227 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1316 1.8e-143 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF13304//PF01926//PF00005//PF03193 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.54884 BP_3 13.59 0.41 1899 642922360 XP_008193124.1 2313 7.6e-258 PREDICTED: sodium-coupled monocarboxylate transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 1054 3.1e-113 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.54887 BP_3 410.60 7.56 2911 642927093 XP_008195135.1 2894 0.0e+00 PREDICTED: rhophilin-2 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TNR1 1245 3.4e-135 Rhophilin-2 OS=Danio rerio GN=rhpn2 PE=2 SV=1 PF02185//PF00595//PF13180 Hr1 repeat//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2220 Predicted signal transduction protein Cluster-8309.54888 BP_3 126.90 4.39 1684 642929512 XP_975068.2 1084 2.2e-115 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Tribolium castaneum] 727003473 XM_010393578.1 39 1.57925e-08 PREDICTED: Corvus cornix cornix 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA K01082 cysQ, MET22, BPNT1 3'(2'), 5'-bisphosphate nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01082 O95861 750 4.8e-78 3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens GN=BPNT1 PE=1 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.54889 BP_3 29.26 1.12 1548 167466181 NP_001107846.1 1215 1.3e-130 cytochrome P450 monooxigenase CYP4Q2 [Tribolium castaneum]>gi|270014305|gb|EFA10753.1| cytochrome P450-like protein [Tribolium castaneum] 815819218 XM_012375356.1 60 3.07067e-20 PREDICTED: Linepithema humile cytochrome P450 4C1-like (LOC105677043), mRNA K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 P29981 855 3.0e-90 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0046872//GO:0016491//GO:0005506//GO:0016705 heme binding//metal ion binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.54890 BP_3 450.11 11.12 2243 642924819 XP_008194054.1 939 1.9e-98 PREDICTED: pre-mRNA 3'-end-processing factor FIP1 isoform X1 [Tribolium castaneum] 755881436 XM_005185743.2 56 7.49862e-18 PREDICTED: Musca domestica pre-mRNA 3'-end-processing factor FIP1 (LOC101888314), mRNA K14405 FIP1L1, FIP1 pre-mRNA 3'-end-processing factor FIP1 http://www.genome.jp/dbget-bin/www_bget?ko:K14405 Q9D824 301 7.5e-26 Pre-mRNA 3'-end-processing factor FIP1 OS=Mus musculus GN=Fip1l1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1049 Polyadenylation factor I complex, subunit FIP1 Cluster-8309.54893 BP_3 4.08 0.36 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54894 BP_3 188.56 2.29 4263 478249815 ENN70322.1 632 1.4e-62 hypothetical protein YQE_12833, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PR54 154 1.6e-08 Telomere-associated protein RIF1 OS=Mus musculus GN=Rif1 PE=1 SV=2 PF02252//PF03118 Proteasome activator pa28 beta subunit//Bacterial RNA polymerase, alpha chain C terminal domain GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0008537//GO:0005730 proteasome activator complex//nucleolus -- -- Cluster-8309.54896 BP_3 101.48 0.90 5706 270007730 EFA04178.1 522 1.1e-49 hypothetical protein TcasGA2_TC014427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0D2 169 3.9e-10 Centrosomal protein of 295 kDa OS=Homo sapiens GN=CEP295 PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54898 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54900 BP_3 49.72 1.82 1608 642917916 XP_008191381.1 387 1.4e-34 PREDICTED: methyltransferase-like protein 17, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U2U7 193 1.8e-13 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.54901 BP_3 45.32 13.94 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54906 BP_3 2.00 0.42 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54909 BP_3 3.46 0.44 670 332374052 AEE62167.1 296 2.1e-24 unknown [Dendroctonus ponderosae]>gi|478263264|gb|ENN81648.1| hypothetical protein YQE_01946, partial [Dendroctonus ponderosae]>gi|546673295|gb|ERL84927.1| hypothetical protein D910_02350 [Dendroctonus ponderosae] -- -- -- -- -- K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P52485 226 1.1e-17 Ubiquitin-conjugating enzyme E2-24 kDa OS=Drosophila melanogaster GN=UbcD2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.5491 BP_3 20.00 0.69 1698 91091008 XP_975006.1 1136 2.1e-121 PREDICTED: homeobox protein BarH-like 1 [Tribolium castaneum]>gi|270013179|gb|EFA09627.1| hypothetical protein TcasGA2_TC011748 [Tribolium castaneum] 642936140 XM_969913.2 242 2.26488e-121 PREDICTED: Tribolium castaneum homeobox protein BarH-like 1 (LOC663883), mRNA K09353 LBX homeobox protein LBX http://www.genome.jp/dbget-bin/www_bget?ko:K09353 Q0P4H6 401 1.4e-37 Transcription factor LBX1 OS=Xenopus tropicalis GN=lbx1 PE=2 SV=1 PF01186//PF00046//PF05920 Lysyl oxidase//Homeobox domain//Homeobox KN domain GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0016641//GO:0003677//GO:0005507//GO:0043565 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//DNA binding//copper ion binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.54912 BP_3 8.00 0.54 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- -- -- Cluster-8309.54913 BP_3 18.00 1.42 902 723587484 AIX97362.1 1380 5.6e-150 heat shock protein 70 [Charybdis japonica] 418206096 JX913781.1 896 0 Scylla paramamosain isolate S5 heat shock protein 70 (hsp70) gene, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P08108 1272 7.7e-139 Heat shock cognate 70 kDa protein OS=Oncorhynchus mykiss GN=hsc71 PE=2 SV=2 PF07748//PF02854//PF01968//PF06723//PF02782 Glycosyl hydrolases family 38 C-terminal domain//MIF4G domain//Hydantoinase/oxoprolinase//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain GO:0000902//GO:0005975//GO:0006013 cell morphogenesis//carbohydrate metabolic process//mannose metabolic process GO:0016787//GO:0003723//GO:0015923//GO:0005515//GO:0016773 hydrolase activity//RNA binding//mannosidase activity//protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.54914 BP_3 21.87 0.50 2406 91085955 XP_971224.1 1844 2.3e-203 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q80V86 622 4.8e-63 Integrator complex subunit 8 OS=Mus musculus GN=Ints8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54920 BP_3 24.37 0.43 3006 780665970 XP_011694053.1 1769 1.5e-194 PREDICTED: uncharacterized protein LOC105453629 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04825//PF00665//PF01361 N terminus of Rad21 / Rec8 like protein//Integrase core domain//Tautomerase enzyme GO:0015074//GO:0006725 DNA integration//cellular aromatic compound metabolic process GO:0016853//GO:0005515 isomerase activity//protein binding -- -- -- -- Cluster-8309.54921 BP_3 90.49 1.61 3006 -- -- -- -- -- 642924274 XM_008196005.1 39 2.84348e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103313241 (LOC103313241), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00008//PF07645//PF13895 EGF-like domain//Calcium-binding EGF domain//Immunoglobulin domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.54923 BP_3 77.24 0.70 5646 642939323 XP_969087.2 928 9.1e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01588//PF07782//PF03876 Putative tRNA binding domain//DC-STAMP-like protein//SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0000049//GO:0003899 tRNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0016021 nucleolus//integral component of membrane KOG2241 tRNA-binding protein Cluster-8309.54926 BP_3 23.11 0.63 2057 642935612 XP_008198081.1 1955 2.7e-216 PREDICTED: probable elongator complex protein 2 [Tribolium castaneum]>gi|270013922|gb|EFA10370.1| hypothetical protein TcasGA2_TC012601 [Tribolium castaneum] 820980913 XM_012506317.1 42 4.16218e-10 PREDICTED: Nomascus leucogenys elongator acetyltransferase complex subunit 2 (ELP2), mRNA K11374 ELP2 elongator complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11374 Q7K4B3 1563 3.2e-172 Probable elongator complex protein 2 OS=Drosophila melanogaster GN=Elp2 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily Cluster-8309.54928 BP_3 1.00 13.75 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54929 BP_3 6.00 0.31 1238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54930 BP_3 324.59 1.28 12504 270013018 EFA09466.1 6037 0.0e+00 hypothetical protein TcasGA2_TC010960 [Tribolium castaneum] 667677299 AE014296.5 67 3.24792e-23 Drosophila melanogaster chromosome 3L K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q923J6 3706 0.0e+00 Dynein heavy chain 12, axonemal OS=Rattus norvegicus GN=Dnah12 PE=2 SV=2 PF00015//PF00580//PF02562//PF00004//PF01695//PF07728//PF00158//PF00910//PF02601//PF03233//PF02096//PF01637//PF03938//PF04851//PF00437//PF03028//PF07724 Methyl-accepting chemotaxis protein (MCP) signalling domain//UvrD/REP helicase N-terminal domain//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//RNA helicase//Exonuclease VII, large subunit//Aphid transmission protein//60Kd inner membrane protein//Archaeal ATPase//Outer membrane protein (OmpH-like)//Type III restriction enzyme, res subunit//Type II/IV secretion system protein//Dynein heavy chain and region D6 of dynein motor//AAA domain (Cdc48 subfamily) GO:0006810//GO:0051205//GO:0007165//GO:0007018//GO:0007017//GO:0006355//GO:0019089//GO:0006308 transport//protein insertion into membrane//signal transduction//microtubule-based movement//microtubule-based process//regulation of transcription, DNA-templated//transmission of virus//DNA catabolic process GO:0008134//GO:0016787//GO:0005524//GO:0016887//GO:0051082//GO:0003777//GO:0008855//GO:0003677//GO:0003723//GO:0003724//GO:0004871 transcription factor binding//hydrolase activity//ATP binding//ATPase activity//unfolded protein binding//microtubule motor activity//exodeoxyribonuclease VII activity//DNA binding//RNA binding//RNA helicase activity//signal transducer activity GO:0016021//GO:0009318//GO:0005667//GO:0005874//GO:0030286//GO:0016020 integral component of membrane//exodeoxyribonuclease VII complex//transcription factor complex//microtubule//dynein complex//membrane -- -- Cluster-8309.54934 BP_3 34.75 0.94 2079 642926434 XP_008191959.1 216 1.2e-14 PREDICTED: serine/threonine-protein phosphatase Pgam5, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15637 PGAM5 serine/threonine-protein phosphatase PGAM5 http://www.genome.jp/dbget-bin/www_bget?ko:K15637 B4PY69 190 5.2e-13 Serine/threonine-protein phosphatase Pgam5, mitochondrial OS=Drosophila yakuba GN=Pgam5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4609 Predicted phosphoglycerate mutase Cluster-8309.54935 BP_3 259.25 6.07 2352 91085197 XP_971808.1 1006 3.4e-106 PREDICTED: serine/threonine-protein phosphatase Pgam5, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008461|gb|EFA04909.1| hypothetical protein TcasGA2_TC014973 [Tribolium castaneum] -- -- -- -- -- K15637 PGAM5 serine/threonine-protein phosphatase PGAM5 http://www.genome.jp/dbget-bin/www_bget?ko:K15637 B3MR30 705 1.1e-72 Serine/threonine-protein phosphatase Pgam5, mitochondrial OS=Drosophila ananassae GN=Pgam5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4609 Predicted phosphoglycerate mutase Cluster-8309.54938 BP_3 729.60 27.47 1572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54943 BP_3 579.57 15.55 2088 189233695 XP_001812208.1 757 2.3e-77 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 611 7.9e-62 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.54947 BP_3 1.00 3.70 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54948 BP_3 140.47 7.40 1207 91083701 XP_969551.1 798 2.3e-82 PREDICTED: PITH domain-containing protein CG6153 [Tribolium castaneum]>gi|270006812|gb|EFA03260.1| hypothetical protein TcasGA2_TC013194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29L80 614 2.0e-62 PITH domain-containing protein GA19395 OS=Drosophila pseudoobscura pseudoobscura GN=GA19395 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1730 Thioredoxin-like protein Cluster-8309.54951 BP_3 106.83 3.78 1655 641667737 XP_008184195.1 486 4.7e-46 PREDICTED: zinc finger protein 227-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q03938 436 1.2e-41 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF13465//PF00096//PF06467//PF16622//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.54952 BP_3 45.36 3.10 997 557025110 XP_006012719.1 402 1.6e-36 PREDICTED: zinc finger protein 850-like [Latimeria chalumnae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P16374 406 2.2e-38 Zinc finger protein 60 OS=Mus musculus GN=Zfp60 PE=2 SV=2 PF13465//PF00096//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.54953 BP_3 10.64 0.65 1075 612027816 XP_007492787.1 371 6.7e-33 PREDICTED: zinc finger protein 420-like isoform X1 [Monodelphis domestica]>gi|612027818|ref|XP_007492788.1| PREDICTED: zinc finger protein 420-like isoform X2 [Monodelphis domestica] -- -- -- -- -- -- -- -- -- P16374 370 3.6e-34 Zinc finger protein 60 OS=Mus musculus GN=Zfp60 PE=2 SV=2 PF02146//PF13465//PF01428//PF07648//PF16622//PF04810//PF13912//PF06397//PF01155//PF00130//PF00096//PF06467//PF02519 Sir2 family//Zinc-finger double domain//AN1-like Zinc finger//Kazal-type serine protease inhibitor domain//zinc-finger C2H2-type//Sec23/Sec24 zinc finger//C2H2-type zinc finger//Desulfoferrodoxin, N-terminal domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//Auxin responsive protein GO:0006888//GO:0006886//GO:0006464//GO:0035556//GO:0009733 ER to Golgi vesicle-mediated transport//intracellular protein transport//cellular protein modification process//intracellular signal transduction//response to auxin GO:0005515//GO:0016151//GO:0070403//GO:0046872//GO:0005506//GO:0008270 protein binding//nickel cation binding//NAD+ binding//metal ion binding//iron ion binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.54956 BP_3 597.69 11.58 2780 642917874 XP_969397.3 2186 6.0e-243 PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R7W3 1050 1.3e-112 Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Macaca fascicularis GN=RALGPS2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.54960 BP_3 352.80 14.58 1458 332376709 AEE63494.1 1834 2.0e-202 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NWM0 504 1.4e-49 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.54961 BP_3 50.23 1.85 1598 332376709 AEE63494.1 1235 6.5e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q6QHF9 464 6.7e-45 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.54964 BP_3 54.75 1.73 1820 91089227 XP_968078.1 575 2.5e-56 PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum]>gi|642932923|ref|XP_008197189.1| PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10186 Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy -- -- -- -- -- -- Cluster-8309.54968 BP_3 2.36 0.48 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54969 BP_3 3.00 0.93 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54971 BP_3 14.64 2.11 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54972 BP_3 36.48 0.60 3242 546683476 ERL93282.1 267 2.3e-20 hypothetical protein D910_10578 [Dendroctonus ponderosae] -- -- -- -- -- K11498 CENPE centromeric protein E http://www.genome.jp/dbget-bin/www_bget?ko:K11498 Q6RT24 209 5.0e-15 Centromere-associated protein E OS=Mus musculus GN=Cenpe PE=1 SV=1 PF08826//PF04675//PF09726//PF03938//PF00225//PF00170//PF00435//PF04111 DMPK coiled coil domain like//DNA ligase N terminus//Transmembrane protein//Outer membrane protein (OmpH-like)//Kinesin motor domain//bZIP transcription factor//Spectrin repeat//Autophagy protein Apg6 GO:0016310//GO:0006310//GO:0007018//GO:0006281//GO:0009069//GO:0006914//GO:0006468//GO:0006260//GO:0006355//GO:0007017 phosphorylation//DNA recombination//microtubule-based movement//DNA repair//serine family amino acid metabolic process//autophagy//protein phosphorylation//DNA replication//regulation of transcription, DNA-templated//microtubule-based process GO:0003677//GO:0005515//GO:0003777//GO:0008017//GO:0003910//GO:0005524//GO:0051082//GO:0043565//GO:0004674//GO:0003700 DNA binding//protein binding//microtubule motor activity//microtubule binding//DNA ligase (ATP) activity//ATP binding//unfolded protein binding//sequence-specific DNA binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding GO:0005874//GO:0005667//GO:0016021//GO:0045298 microtubule//transcription factor complex//integral component of membrane//tubulin complex KOG0242 Kinesin-like protein Cluster-8309.54974 BP_3 6.19 0.43 989 -- -- -- -- -- 462310927 APGK01047154.1 60 1.93881e-20 Dendroctonus ponderosae Seq01047164, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54977 BP_3 15.00 16.50 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54978 BP_3 84.49 5.59 1020 321472662 EFX83631.1 442 3.7e-41 hypothetical protein DAPPUDRAFT_100237 [Daphnia pulex] -- -- -- -- -- K03135 TAF11 transcription initiation factor TFIID subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K03135 Q99JX1 373 1.5e-34 Transcription initiation factor TFIID subunit 11 OS=Mus musculus GN=Taf11 PE=2 SV=1 PF17085//PF12289//PF04719 Unique cartilage matrix associated protein//Rotavirus VP1 C-terminal domain//hTAFII28-like protein conserved region GO:0045667//GO:0006144//GO:0006367 regulation of osteoblast differentiation//purine nucleobase metabolic process//transcription initiation from RNA polymerase II promoter GO:0003968 RNA-directed RNA polymerase activity GO:0005634//GO:0031379 nucleus//RNA-directed RNA polymerase complex -- -- Cluster-8309.5498 BP_3 3.00 0.45 612 675694793 XP_002754570.3 1000 4.4e-106 PREDICTED: heat shock cognate 71 kDa protein [Callithrix jacchus] 209402725 FJ224294.1 612 0 Homo sapiens epididymis secretory sperm binding protein Li 72p (HEL-S-72p) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P63018 926 6.9e-99 Heat shock cognate 71 kDa protein OS=Rattus norvegicus GN=Hspa8 PE=1 SV=1 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.54981 BP_3 185.27 36.54 536 270012085 EFA08533.1 386 6.0e-35 hypothetical protein TcasGA2_TC006187 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54983 BP_3 358.04 1.47 12039 549084993 BAO00914.1 2003 4.3e-221 broad-complex [Psacothea hilaris] 549084992 AB857715.1 1041 0 Psacothea hilaris PhBR-C_Z1 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q01295 609 7.8e-61 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00130//PF00096//PF13465//PF00651//PF16622//PF03854//PF02892//PF01363//PF13912 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc-finger double domain//BTB/POZ domain//zinc-finger C2H2-type//P-11 zinc finger//BED zinc finger//FYVE zinc finger//C2H2-type zinc finger GO:0035556 intracellular signal transduction GO:0005515//GO:0046872//GO:0008270//GO:0003723//GO:0003677 protein binding//metal ion binding//zinc ion binding//RNA binding//DNA binding -- -- -- -- Cluster-8309.54984 BP_3 36.55 0.52 3695 549150209 BAO01156.1 1009 2.4e-106 broad-complex [Psacothea hilaris] 549150208 AB858993.1 1040 0 Psacothea hilaris PhBR-C_Z5Z6 mRNA for broad-complex, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54985 BP_3 24.56 2.45 775 189239014 XP_974755.2 424 3.4e-39 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 176 8.1e-12 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54986 BP_3 57.67 0.38 7550 642927353 XP_008195233.1 3614 0.0e+00 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 7-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TE60 682 1.7e-69 A disintegrin and metalloproteinase with thrombospondin motifs 18 OS=Homo sapiens GN=ADAMTS18 PE=1 SV=3 PF00413//PF01562//PF01421//PF15339//PF13181 Matrixin//Reprolysin family propeptide//Reprolysin (M12B) family zinc metalloprotease//Acrosome formation-associated factor//Tetratricopeptide repeat GO:0007342//GO:0060478//GO:0006897//GO:0006508 fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis//endocytosis//proteolysis GO:0004222//GO:0005515//GO:0008270 metalloendopeptidase activity//protein binding//zinc ion binding GO:0005886//GO:0031012 plasma membrane//extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.54987 BP_3 50.26 1.03 2634 642916487 XP_008191063.1 996 5.5e-105 PREDICTED: glutathione S-transferase-like [Tribolium castaneum]>gi|642916489|ref|XP_008191064.1| PREDICTED: glutathione S-transferase-like [Tribolium castaneum]>gi|270003617|gb|EFA00065.1| hypothetical protein TcasGA2_TC002878 [Tribolium castaneum] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 466 6.5e-45 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF05529//PF13417//PF02798//PF13409 B-cell receptor-associated protein 31-like//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006886 intracellular protein transport GO:0005515 protein binding GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane KOG1695 Glutathione S-transferase Cluster-8309.54990 BP_3 352.66 3.81 4754 642925869 XP_008190626.1 2498 6.8e-279 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 Q9P2N4 1274 2.4e-138 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF01562//PF05986//PF00413//PF01421 Reprolysin family propeptide//ADAM-TS Spacer 1//Matrixin//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.54991 BP_3 44.47 0.42 5403 91084037 XP_966813.1 287 1.8e-22 PREDICTED: putative defense protein Hdd11 [Tribolium castaneum]>gi|642924804|ref|XP_008194048.1| PREDICTED: putative defense protein Hdd11 [Tribolium castaneum]>gi|270006698|gb|EFA03146.1| hypothetical protein TcasGA2_TC013059 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86RS3 192 7.9e-13 Putative defense protein Hdd11-like OS=Manduca sexta PE=2 SV=1 PF00864 ATP P2X receptor GO:0007165//GO:0006812//GO:0098655//GO:0033198 signal transduction//cation transport//cation transmembrane transport//response to ATP GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.54992 BP_3 125.83 9.99 899 91093645 XP_967622.1 952 2.4e-100 PREDICTED: translation initiation factor eIF-2B subunit beta [Tribolium castaneum]>gi|270015813|gb|EFA12261.1| hypothetical protein TcasGA2_TC016125 [Tribolium castaneum] -- -- -- -- -- K03754 EIF2B2 translation initiation factor eIF-2B subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03754 Q90511 660 7.1e-68 Translation initiation factor eIF-2B subunit beta OS=Takifugu rubripes GN=eif2b2 PE=3 SV=1 PF01008 Initiation factor 2 subunit family GO:0044237 cellular metabolic process -- -- -- -- KOG1465 Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7) Cluster-8309.54998 BP_3 62.02 0.35 8722 270007727 EFA04175.1 2353 8.1e-262 hypothetical protein TcasGA2_TC014424 [Tribolium castaneum] 642923781 XM_008195660.1 114 1.68833e-49 PREDICTED: Tribolium castaneum regulating synaptic membrane exocytosis protein 2 (LOC663311), mRNA K15297 RIMS2, RIM2 regulating synaptic membrane exocytosis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15297 Q9UQ26 647 2.2e-65 Regulating synaptic membrane exocytosis protein 2 OS=Homo sapiens GN=RIMS2 PE=1 SV=2 PF00595//PF00168 PDZ domain (Also known as DHR or GLGF)//C2 domain -- -- GO:0005515 protein binding -- -- KOG2060 Rab3 effector RIM1 and related proteins, contain PDZ and C2 domains Cluster-8309.55 BP_3 5.00 0.63 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5500 BP_3 4.00 0.45 716 307172808 EFN64048.1 215 5.4e-15 hypothetical protein EAG_09261, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55000 BP_3 43.00 2.43 1145 270007727 EFA04175.1 1105 5.5e-118 hypothetical protein TcasGA2_TC014424 [Tribolium castaneum] 462299229 APGK01051387.1 59 8.11226e-20 Dendroctonus ponderosae Seq01051397, whole genome shotgun sequence K15297 RIMS2, RIM2 regulating synaptic membrane exocytosis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15297 Q9JIS1 324 8.2e-29 Regulating synaptic membrane exocytosis protein 2 OS=Rattus norvegicus GN=Rims2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain Cluster-8309.55003 BP_3 177.92 1.24 7232 546684778 ERL94373.1 2654 8.4e-297 hypothetical protein D910_11653 [Dendroctonus ponderosae] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 1450 1.4e-158 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF05175//PF08241//PF05206//PF10391//PF05148//PF00270 Methyltransferase small domain//Methyltransferase domain//Methyltransferase TRM13//Fingers domain of DNA polymerase lambda//Hypothetical methyltransferase//DEAD/DEAH box helicase GO:0008152//GO:0008033 metabolic process//tRNA processing GO:0005524//GO:0003677//GO:0034061//GO:0008168//GO:0003676 ATP binding//DNA binding//DNA polymerase activity//methyltransferase activity//nucleic acid binding GO:0005634 nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.55004 BP_3 4.00 0.43 735 295982350 3KWQ 410 1.4e-37 Chain B, Structural Characterization Of H3k56q Nucleosomes And Nucleo Arrays>gi|295982354|pdb|3KWQ|F Chain F, Structural Characterization Of H3k56q Nucleosomes And Nucleo Arrays>gi|409107476|pdb|4H9S|C Chain C, Complex Structure 6 Of DaxxH3.3(SUB7)H4>gi|409107477|pdb|4H9S|D Chain D, Complex Structure 6 Of DaxxH3.3(SUB7)H4 512938600 XM_004933988.1 124 3.76569e-56 PREDICTED: Bombyx mori histone H4-like (LOC101736075), mRNA K11254 H4 histone H4 http://www.genome.jp/dbget-bin/www_bget?ko:K11254 P62790 361 2.7e-33 Histone H4 OS=Sterkiella nova PE=3 SV=2 PF02291//PF00125//PF02969 Transcription initiation factor IID, 31kD subunit//Core histone H2A/H2B/H3/H4//TATA box binding protein associated factor (TAF) GO:0006352//GO:0006334 DNA-templated transcription, initiation//nucleosome assembly GO:0046982//GO:0003677 protein heterodimerization activity//DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.55005 BP_3 59.00 11.78 533 620949140 XP_001513000.2 694 1.2e-70 PREDICTED: uncharacterized protein LOC100089390 [Ornithorhynchus anatinus] 27923434 AY125228.1 164 1.55722e-78 Ophiogomphus severus histone 3 gene, partial cds K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P84234 675 7.6e-70 Histone H3.2 OS=Oncorhynchus mykiss PE=1 SV=2 PF15715//PF00125 PCNA-associated factor//Core histone H2A/H2B/H3/H4 GO:0051726//GO:0006974 regulation of cell cycle//cellular response to DNA damage stimulus GO:0003677 DNA binding -- -- -- -- Cluster-8309.55007 BP_3 82.00 1.41 3096 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55008 BP_3 14.27 0.37 2132 91092760 XP_973551.1 1243 1.0e-133 PREDICTED: protein BCL9 homolog [Tribolium castaneum]>gi|270014793|gb|EFA11241.1| hypothetical protein TcasGA2_TC010773 [Tribolium castaneum] 642911481 XM_968458.3 396 0 PREDICTED: Tribolium castaneum protein BCL9 homolog (LOC662357), mRNA -- -- -- -- Q961D9 234 4.2e-18 Protein BCL9 homolog OS=Drosophila melanogaster GN=lgs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55010 BP_3 1.93 6.73 275 549438545 AGX25161.1 142 6.1e-07 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55012 BP_3 123.26 1.10 5699 549438545 AGX25161.1 2415 3.4e-269 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 1472 3.1e-161 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF00326//PF04060//PF02129//PF01738//PF00930//PF03583 Prolyl oligopeptidase family//Putative Fe-S cluster//X-Pro dipeptidyl-peptidase (S15 family)//Dienelactone hydrolase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Secretory lipase GO:0006508//GO:0016042//GO:0046486 proteolysis//lipid catabolic process//glycerolipid metabolic process GO:0016787//GO:0051536//GO:0008236//GO:0004806 hydrolase activity//iron-sulfur cluster binding//serine-type peptidase activity//triglyceride lipase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.55013 BP_3 77.18 1.17 3463 642932825 XP_008197001.1 2058 5.2e-228 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 1083 2.4e-116 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019//PF00957 Gamma-glutamyltranspeptidase//Synaptobrevin GO:0006693//GO:0006749//GO:0019530//GO:0016192//GO:0006691 prostaglandin metabolic process//glutathione metabolic process//taurine metabolic process//vesicle-mediated transport//leukotriene metabolic process GO:0003840 gamma-glutamyltransferase activity GO:0016021 integral component of membrane KOG2410 Gamma-glutamyltransferase Cluster-8309.55014 BP_3 1.00 0.32 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15339//PF00957 Acrosome formation-associated factor//Synaptobrevin GO:0060478//GO:0007342//GO:0006897//GO:0016192 acrosomal vesicle exocytosis//fusion of sperm to egg plasma membrane//endocytosis//vesicle-mediated transport -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.55016 BP_3 8.00 1.82 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55017 BP_3 73.00 2.38 1772 91094245 XP_968572.1 479 3.3e-45 PREDICTED: transcription factor 21 [Tribolium castaneum]>gi|270016269|gb|EFA12715.1| hypothetical protein TcasGA2_TC002349 [Tribolium castaneum] -- -- -- -- -- K09072 MSC musculin (activated B-cell factor-1) http://www.genome.jp/dbget-bin/www_bget?ko:K09072 O88940 240 7.0e-19 Musculin OS=Mus musculus GN=Msc PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.55025 BP_3 44.35 0.87 2735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55026 BP_3 18.00 0.80 1380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.55029 BP_3 95.93 2.81 1939 642916248 XP_008190945.1 1988 3.8e-220 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642916250|ref|XP_008190946.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270003683|gb|EFA00131.1| hypothetical protein TcasGA2_TC002947 [Tribolium castaneum] -- -- -- -- -- K08202 SLC22A4_5, OCTN MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K08202 Q9VCA2 1558 1.1e-171 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.55031 BP_3 287.43 3.55 4195 642919497 XP_008191896.1 2940 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55032 BP_3 593.58 5.53 5463 642919497 XP_008191896.1 2940 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55034 BP_3 335.97 8.94 2103 189233639 XP_001813427.1 925 7.5e-97 PREDICTED: tight junction protein ZO-3 [Tribolium castaneum]>gi|642910523|ref|XP_008200248.1| PREDICTED: tight junction protein ZO-3 [Tribolium castaneum]>gi|270014407|gb|EFA10855.1| hypothetical protein TcasGA2_TC001632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZR8 271 2.1e-22 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.5504 BP_3 2.00 1.90 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55043 BP_3 82.74 2.02 2265 91079796 XP_968202.1 2037 9.2e-226 PREDICTED: protein GPR107 [Tribolium castaneum]>gi|270003308|gb|EEZ99755.1| hypothetical protein TcasGA2_TC002527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BUV8 1081 2.7e-116 Protein GPR107 OS=Mus musculus GN=Gpr107 PE=2 SV=2 PF06814//PF10192//PF04420 Lung seven transmembrane receptor//Rhodopsin-like GPCR transmembrane domain//CHD5-like protein GO:0019236//GO:0071816//GO:0007186 response to pheromone//tail-anchored membrane protein insertion into ER membrane//G-protein coupled receptor signaling pathway -- -- GO:0016021 integral component of membrane KOG2569 G protein-coupled seven transmembrane receptor Cluster-8309.55044 BP_3 15.95 0.33 2601 91079796 XP_968202.1 1569 2.0e-171 PREDICTED: protein GPR107 [Tribolium castaneum]>gi|270003308|gb|EEZ99755.1| hypothetical protein TcasGA2_TC002527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BUV8 985 4.2e-105 Protein GPR107 OS=Mus musculus GN=Gpr107 PE=2 SV=2 PF06814//PF08041//PF04420//PF10192 Lung seven transmembrane receptor//PetM family of cytochrome b6f complex subunit 7//CHD5-like protein//Rhodopsin-like GPCR transmembrane domain GO:0071816//GO:0007186//GO:0019236 tail-anchored membrane protein insertion into ER membrane//G-protein coupled receptor signaling pathway//response to pheromone -- -- GO:0009512//GO:0016021 cytochrome b6f complex//integral component of membrane KOG2569 G protein-coupled seven transmembrane receptor Cluster-8309.55045 BP_3 1089.25 25.86 2322 91079796 XP_968202.1 2037 9.4e-226 PREDICTED: protein GPR107 [Tribolium castaneum]>gi|270003308|gb|EEZ99755.1| hypothetical protein TcasGA2_TC002527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BUV8 1081 2.8e-116 Protein GPR107 OS=Mus musculus GN=Gpr107 PE=2 SV=2 PF06814//PF10192//PF04420 Lung seven transmembrane receptor//Rhodopsin-like GPCR transmembrane domain//CHD5-like protein GO:0071816//GO:0007186//GO:0019236 tail-anchored membrane protein insertion into ER membrane//G-protein coupled receptor signaling pathway//response to pheromone -- -- GO:0016021 integral component of membrane KOG2569 G protein-coupled seven transmembrane receptor Cluster-8309.55046 BP_3 1.74 0.36 524 91079796 XP_968202.1 194 1.1e-12 PREDICTED: protein GPR107 [Tribolium castaneum]>gi|270003308|gb|EEZ99755.1| hypothetical protein TcasGA2_TC002527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.55047 BP_3 631.24 34.96 1162 642931053 XP_973827.2 1132 4.1e-121 PREDICTED: isoaspartyl peptidase/L-asparaginase [Tribolium castaneum] -- -- -- -- -- K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q29I93 723 4.5e-75 Probable isoaspartyl peptidase/L-asparaginase GA20639 OS=Drosophila pseudoobscura pseudoobscura GN=GA20639 PE=3 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1592 Asparaginase Cluster-8309.55048 BP_3 12.73 0.48 1569 642931053 XP_973827.2 854 9.6e-89 PREDICTED: isoaspartyl peptidase/L-asparaginase [Tribolium castaneum] -- -- -- -- -- K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q5BKW9 579 3.0e-58 Isoaspartyl peptidase/L-asparaginase OS=Danio rerio GN=asrgl1 PE=2 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1592 Asparaginase Cluster-8309.55051 BP_3 120.32 1.74 3633 642936806 XP_008199624.1 2898 0.0e+00 PREDICTED: protein sickie isoform X2 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 4.0e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF00004//PF13851//PF08172//PF07728//PF01695//PF06156//PF03796//PF01443//PF08702//PF00769//PF00910//PF03836//PF09726//PF02562 ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//CASP C terminal//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Protein of unknown function (DUF972)//DnaB-like helicase C terminal domain//Viral (Superfamily 1) RNA helicase//Fibrinogen alpha/beta chain family//Ezrin/radixin/moesin family//RNA helicase//RasGAP C-terminus//Transmembrane protein//PhoH-like protein GO:0007165//GO:0051258//GO:0006260//GO:0006891//GO:0048870//GO:0030168//GO:0007264 signal transduction//protein polymerization//DNA replication//intra-Golgi vesicle-mediated transport//cell motility//platelet activation//small GTPase mediated signal transduction GO:0005524//GO:0005096//GO:0016887//GO:0005102//GO:0003678//GO:0008092//GO:0003723//GO:0030674//GO:0003724 ATP binding//GTPase activator activity//ATPase activity//receptor binding//DNA helicase activity//cytoskeletal protein binding//RNA binding//protein binding, bridging//RNA helicase activity GO:0016021//GO:0019898//GO:0031514//GO:0005577//GO:0005737//GO:0005657//GO:0030173 integral component of membrane//extrinsic component of membrane//motile cilium//fibrinogen complex//cytoplasm//replication fork//integral component of Golgi membrane -- -- Cluster-8309.55055 BP_3 37.51 2.02 1185 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55056 BP_3 92.87 3.59 1539 642929034 XP_008195662.1 494 5.2e-47 PREDICTED: borealin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLD6 143 1.1e-07 Borealin OS=Drosophila melanogaster GN=borr PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55057 BP_3 41.70 0.85 2644 478255522 ENN75739.1 1082 5.9e-115 hypothetical protein YQE_07699, partial [Dendroctonus ponderosae] -- -- -- -- -- K05751 ABI2 abl interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05751 P62484 462 1.9e-44 Abl interactor 2 OS=Mus musculus GN=Abi2 PE=2 SV=1 PF01110//PF14604//PF00018//PF03153//PF07815//PF00031 Ciliary neurotrophic factor//Variant SH3 domain//SH3 domain//Transcription factor IIA, alpha/beta subunit//Abl-interactor HHR//Cystatin domain GO:0040007//GO:0006367 growth//transcription initiation from RNA polymerase II promoter GO:0004869//GO:0005515 cysteine-type endopeptidase inhibitor activity//protein binding GO:0005672//GO:0005737 transcription factor TFIIA complex//cytoplasm KOG2546 Abl interactor ABI-1, contains SH3 domain Cluster-8309.55058 BP_3 136.02 3.36 2243 642914217 XP_008201594.1 1758 2.0e-193 PREDICTED: abl interactor 2-like [Tribolium castaneum]>gi|270001565|gb|EEZ98012.1| hypothetical protein TcasGA2_TC000412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NYB9 522 1.8e-51 Abl interactor 2 OS=Homo sapiens GN=ABI2 PE=1 SV=1 PF07815//PF00031//PF00018//PF14604//PF01110 Abl-interactor HHR//Cystatin domain//SH3 domain//Variant SH3 domain//Ciliary neurotrophic factor GO:0040007 growth GO:0005515//GO:0004869 protein binding//cysteine-type endopeptidase inhibitor activity GO:0005737 cytoplasm KOG2546 Abl interactor ABI-1, contains SH3 domain Cluster-8309.55060 BP_3 43.55 1.29 1923 642921796 XP_008199323.1 458 9.7e-43 PREDICTED: transcription initiation factor IIB [Tribolium castaneum]>gi|270006604|gb|EFA03052.1| hypothetical protein TcasGA2_TC010900 [Tribolium castaneum] 564239149 XM_006276368.1 53 2.98315e-16 PREDICTED: Alligator mississippiensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 411 1.1e-38 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 -- -- GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0008270//GO:0017025 zinc ion binding//TBP-class protein binding -- -- KOG1597 Transcription initiation factor TFIIB Cluster-8309.55062 BP_3 102.93 1.36 3951 357622566 EHJ73993.1 2017 3.3e-223 fanconi anemia group J protein [Danaus plexippus] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 1803 9.0e-200 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 PF13307//PF00270//PF04851//PF02562//PF00176//PF06733 Helicase C-terminal domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//PhoH-like protein//SNF2 family N-terminal domain//DEAD_2 GO:0006139 nucleobase-containing compound metabolic process GO:0008026//GO:0003677//GO:0016787//GO:0005524//GO:0016818//GO:0003676//GO:0004003 ATP-dependent helicase activity//DNA binding//hydrolase activity//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//ATP-dependent DNA helicase activity GO:0005657 replication fork KOG1132 Helicase of the DEAD superfamily Cluster-8309.55063 BP_3 1151.98 9.74 5995 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55065 BP_3 12.00 1.38 712 283468932 CAP53905.1 240 6.8e-18 histone H1 orphon [Xenoturbella bocki] -- -- -- -- -- K11275 H1_5 histone H1/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11275 P15870 207 1.9e-15 Histone H1-delta OS=Strongylocentrotus purpuratus PE=3 SV=1 PF00538//PF01402 linker histone H1 and H5 family//Ribbon-helix-helix protein, copG family GO:0006355//GO:0006334 regulation of transcription, DNA-templated//nucleosome assembly GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.55066 BP_3 366.51 3.16 5888 642937896 XP_008200347.1 2573 1.7e-287 PREDICTED: protein vav isoform X1 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 1473 2.5e-161 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF00130//PF00307//PF14604//PF00018//PF00621 Phorbol esters/diacylglycerol binding domain (C1 domain)//Calponin homology (CH) domain//Variant SH3 domain//SH3 domain//RhoGEF domain GO:0035023//GO:0043087//GO:0035556 regulation of Rho protein signal transduction//regulation of GTPase activity//intracellular signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.55067 BP_3 77.66 0.65 6011 642937896 XP_008200347.1 1739 8.8e-191 PREDICTED: protein vav isoform X1 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 1007 2.7e-107 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF07649//PF00621//PF00018//PF14604//PF00307//PF00130 C1-like domain//RhoGEF domain//SH3 domain//Variant SH3 domain//Calponin homology (CH) domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0055114//GO:0035023//GO:0043087 intracellular signal transduction//oxidation-reduction process//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0047134//GO:0005515//GO:0005089 protein-disulfide reductase activity//protein binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.55075 BP_3 14.46 0.33 2396 308495432 XP_003109904.1 255 4.2e-19 hypothetical protein CRE_06611 [Caenorhabditis remanei]>gi|308244741|gb|EFO88693.1| hypothetical protein CRE_06611 [Caenorhabditis remanei] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55078 BP_3 5.00 2.09 406 642939245 XP_008194776.1 275 3.4e-22 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X5 [Tribolium castaneum]>gi|642939247|ref|XP_008194777.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X5 [Tribolium castaneum]>gi|642939249|ref|XP_008194778.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X5 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q9U3D4 200 6.9e-15 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Caenorhabditis elegans GN=sms-1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.55079 BP_3 412.05 7.21 3047 189236300 XP_001815376.1 2442 1.4e-272 PREDICTED: uncharacterized protein LOC100141693 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55080 BP_3 159.91 1.84 4474 642919497 XP_008191896.1 2883 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55081 BP_3 151.74 13.01 854 478259797 ENN79625.1 512 2.4e-49 hypothetical protein YQE_03914, partial [Dendroctonus ponderosae]>gi|478269270|gb|ENN83314.1| hypothetical protein YQE_00330, partial [Dendroctonus ponderosae] -- -- -- -- -- K14860 TMA16 translation machinery-associated protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K14860 Q9VXY4 343 3.8e-31 Translation machinery-associated protein 16 homolog OS=Drosophila melanogaster GN=CG15027 PE=2 SV=2 PF07743//PF04558 HSCB C-terminal oligomerisation domain//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 GO:0006418//GO:0051259 tRNA aminoacylation for protein translation//protein oligomerization GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.55082 BP_3 219.45 2.38 4742 546686097 ERL95494.1 1149 1.8e-122 hypothetical protein D910_12756 [Dendroctonus ponderosae] 807033242 XM_004529566.2 72 2.03773e-26 PREDICTED: Ceratitis capitata TM2 domain-containing protein almondex (LOC101449885), mRNA -- -- -- -- Q9U4H5 645 2.0e-65 TM2 domain-containing protein almondex OS=Drosophila melanogaster GN=amx PE=2 SV=1 PF06743//PF05733 FAST kinase-like protein, subdomain 1//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0004672//GO:0003723 protein kinase activity//RNA binding GO:0019013 viral nucleocapsid KOG4272 Predicted GTP-binding protein Cluster-8309.55086 BP_3 264.29 2.23 6004 91090340 XP_967097.1 1862 4.8e-205 PREDICTED: hexosaminidase D [Tribolium castaneum]>gi|270013820|gb|EFA10268.1| hypothetical protein TcasGA2_TC012468 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 807 4.3e-84 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728//PF02259 Glycosyl hydrolase family 20, catalytic domain//FAT domain GO:0005975 carbohydrate metabolic process GO:0005515//GO:0043169//GO:0004553 protein binding//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.55093 BP_3 886.00 8.45 5345 270006420 EFA02868.1 5545 0.0e+00 hypothetical protein TcasGA2_TC007861 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- F7J220 181 1.5e-11 Scavenger receptor cysteine-rich domain superfamily protein OS=Patiria pectinifera GN=SRCR1 PE=1 SV=1 PF15494//PF01245//PF02854//PF00530 Scavenger receptor cysteine-rich domain//Ribosomal protein L19//MIF4G domain//Scavenger receptor cysteine-rich domain GO:0006412//GO:0007165//GO:0042254 translation//signal transduction//ribosome biogenesis GO:0005515//GO:0005044//GO:0003723//GO:0003735 protein binding//scavenger receptor activity//RNA binding//structural constituent of ribosome GO:0005622//GO:0016020//GO:0005840 intracellular//membrane//ribosome -- -- Cluster-8309.55095 BP_3 255.77 9.92 1535 642914561 XP_008201730.1 474 1.1e-44 PREDICTED: uncharacterized protein LOC660094 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55096 BP_3 73.99 2.98 1489 270014491 EFA10939.1 919 2.6e-96 hypothetical protein TcasGA2_TC001770 [Tribolium castaneum] 751473836 XM_011193984.1 66 1.36326e-23 PREDICTED: Bactrocera cucurbitae endochitinase (LOC105218422), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 P36362 788 1.7e-82 Endochitinase OS=Manduca sexta PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.55098 BP_3 1416.21 8.50 8323 642920424 XP_008192344.1 2195 1.6e-243 PREDICTED: fasciclin-2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1510 1.8e-165 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF05864//PF13895//PF07354//PF00041//PF16656 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006206//GO:0006771//GO:0019497//GO:0006144//GO:0007339//GO:0006351 pyrimidine nucleobase metabolic process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//purine nucleobase metabolic process//binding of sperm to zona pellucida//transcription, DNA-templated GO:0046872//GO:0003993//GO:0005515//GO:0003677//GO:0003899 metal ion binding//acid phosphatase activity//protein binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005576 nucleolus//extracellular region -- -- Cluster-8309.55099 BP_3 1320.80 17.85 3858 642920424 XP_008192344.1 2430 4.2e-271 PREDICTED: fasciclin-2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1590 4.4e-175 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF05864//PF16656//PF07354//PF13895//PF00041 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0006206//GO:0006144//GO:0007339//GO:0019497//GO:0006351 riboflavin metabolic process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//transcription, DNA-templated GO:0046872//GO:0003993//GO:0005515//GO:0003899//GO:0003677 metal ion binding//acid phosphatase activity//protein binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005576 nucleolus//extracellular region -- -- Cluster-8309.551 BP_3 16.00 0.58 1631 270004310 EFA00758.1 833 2.7e-86 hypothetical protein TcasGA2_TC003644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DIM3 566 1.0e-56 Tubulin delta chain OS=Xenopus tropicalis GN=tubd1 PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1374 Gamma tubulin Cluster-8309.55100 BP_3 247.29 3.24 3966 642920420 XP_008192342.1 2610 5.8e-292 PREDICTED: fasciclin-2 isoform X1 [Tribolium castaneum] 642920419 XM_008194120.1 83 1.30624e-32 PREDICTED: Tribolium castaneum fasciclin-2 (LOC664545), transcript variant X1, mRNA K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1640 7.2e-181 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF16656//PF07354//PF00041//PF13895//PF05864 Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Immunoglobulin domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) GO:0006771//GO:0006206//GO:0006351//GO:0006144//GO:0007339//GO:0019497 riboflavin metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0003899//GO:0003677//GO:0005515 acid phosphatase activity//metal ion binding//DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005576//GO:0005730 extracellular region//nucleolus -- -- Cluster-8309.55102 BP_3 57.19 1.83 1797 642919375 XP_008191845.1 373 6.5e-33 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26618 185 1.7e-12 Platelet-derived growth factor receptor alpha OS=Mus musculus GN=Pdgfra PE=1 SV=3 PF01325 Iron dependent repressor, N-terminal DNA binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.55104 BP_3 9.00 0.37 1477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55105 BP_3 631.85 9.49 3502 646695578 KDR08392.1 995 9.6e-105 Ankyrin repeat domain-containing protein 29, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q502M6 578 8.9e-58 Ankyrin repeat domain-containing protein 29 OS=Danio rerio GN=ankrd29 PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55106 BP_3 6.00 0.64 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5511 BP_3 16.00 0.34 2558 642921423 XP_008192860.1 2550 3.4e-285 PREDICTED: probable protein S-acyltransferase 23 [Tribolium castaneum]>gi|270006293|gb|EFA02741.1| hypothetical protein TcasGA2_TC008472 [Tribolium castaneum] 347973015 XM_319681.3 252 9.48637e-127 Anopheles gambiae str. PEST AGAP008928-PA (AgaP_AGAP008928) mRNA, partial cds -- -- -- -- Q3EC11 526 6.9e-52 Probable protein S-acyltransferase 23 OS=Arabidopsis thaliana GN=PAT23 PE=2 SV=2 PF13606//PF01529//PF00023//PF08115 Ankyrin repeat//DHHC palmitoyltransferase//Ankyrin repeat//SFI toxin family GO:0009405 pathogenesis GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.55111 BP_3 27.00 0.80 1923 270015255 EFA11703.1 629 1.4e-62 hypothetical protein TcasGA2_TC001790 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55113 BP_3 40.99 1.03 2205 270008606 EFA05054.1 1594 2.1e-174 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 485 3.4e-47 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF08053 Tryptophanase operon leader peptide GO:0031554//GO:0031556 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.55114 BP_3 17.47 0.50 1981 665788269 XP_008559724.1 753 6.2e-77 PREDICTED: uncharacterized protein LOC103579935 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08398 Parvovirus coat protein VP1 -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.55120 BP_3 36.42 0.60 3236 642911196 XP_008199563.1 2703 7.8e-303 PREDICTED: solute carrier family 12 member 4 isoform X1 [Tribolium castaneum] 768953561 XM_011617286.1 47 1.09413e-12 PREDICTED: Takifugu rubripes solute carrier family 12 (potassium/chloride transporter), member 6 (slc12a6), mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2008 1.2e-223 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF13520//PF03522//PF00324 Amino acid permease//Solute carrier family 12//Amino acid permease GO:0006865//GO:0055085//GO:0006810//GO:0003333//GO:0006811 amino acid transport//transmembrane transport//transport//amino acid transmembrane transport//ion transport GO:0015171//GO:0005215 amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.55123 BP_3 72.58 7.77 742 642918845 XP_008191611.1 330 2.6e-28 PREDICTED: phosphoglycolate phosphatase 2-like [Tribolium castaneum]>gi|270005689|gb|EFA02137.1| hypothetical protein TcasGA2_TC007787 [Tribolium castaneum] -- -- -- -- -- K01101 E3.1.3.41 4-nitrophenyl phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01101 -- -- -- -- -- -- GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.55124 BP_3 112.57 2.68 2317 642915624 XP_008190712.1 2350 4.8e-262 PREDICTED: protein tramtrack, beta isoform isoform X2 [Tribolium castaneum] 642915623 XM_008192490.1 419 0 PREDICTED: Tribolium castaneum protein tramtrack, beta isoform (LOC660343), transcript variant X4, mRNA -- -- -- -- Q7KRI2 222 1.1e-16 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651//PF05225//PF02796//PF05007 BTB/POZ domain//helix-turn-helix, Psq domain//Helix-turn-helix domain of resolvase//Mannosyltransferase (PIG-M) GO:0006506//GO:0006310 GPI anchor biosynthetic process//DNA recombination GO:0005515//GO:0000150//GO:0003677//GO:0016758 protein binding//recombinase activity//DNA binding//transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane -- -- Cluster-8309.55126 BP_3 5.62 0.38 1010 642921483 XP_008192888.1 430 9.0e-40 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00939 Sodium:sulfate symporter transmembrane region GO:0006810//GO:0055085//GO:0006814 transport//transmembrane transport//sodium ion transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.55127 BP_3 12.83 0.80 1067 332027123 EGI67218.1 743 4.8e-76 FLJ37770-like protein, partial [Acromyrmex echinatior] 795011845 XM_012019428.1 678 0 PREDICTED: Vollenhovia emeryi putative uncharacterized protein FLJ37770 (LOC105565876), mRNA -- -- -- -- Q3ZCU0 256 5.9e-21 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 PF13443//PF02070 Cro/C1-type HTH DNA-binding domain//Neuromedin U GO:0006940 regulation of smooth muscle contraction GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.55131 BP_3 33.25 1.09 1765 768418838 XP_011550121.1 216 1.0e-14 PREDICTED: uncharacterized protein LOC105382004 [Plutella xylostella]>gi|768424236|ref|XP_011553062.1| PREDICTED: uncharacterized protein LOC105384507 [Plutella xylostella]>gi|768439288|ref|XP_011561267.1| PREDICTED: uncharacterized protein LOC105391485 [Plutella xylostella]>gi|768449353|ref|XP_011566757.1| PREDICTED: uncharacterized protein LOC105396454 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55135 BP_3 73.05 0.88 4271 642910866 XP_001813884.2 1750 3.3e-192 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1157 7.9e-125 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF03938//PF08123//PF04977//PF02390//PF00103 Outer membrane protein (OmpH-like)//Histone methylation protein DOT1//Septum formation initiator//Putative methyltransferase//Somatotropin hormone family GO:0008033//GO:0006554//GO:0007049//GO:0006400//GO:0006479//GO:0009451//GO:0007165 tRNA processing//lysine catabolic process//cell cycle//tRNA modification//protein methylation//RNA modification//signal transduction GO:0008176//GO:0051082//GO:0005179//GO:0018024 tRNA (guanine-N7-)-methyltransferase activity//unfolded protein binding//hormone activity//histone-lysine N-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.55148 BP_3 74.44 0.57 6552 449689435 XP_004212030.1 216 3.8e-14 PREDICTED: uncharacterized protein LOC101241870 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00722 Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.55149 BP_3 39.56 0.35 5747 102939 188 5.9e-11 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- -- -- -- -- PF00722 Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.55151 BP_3 4.00 0.94 497 270003164 EEZ99611.1 167 1.4e-09 hypothetical protein TcasGA2_TC002128 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.55153 BP_3 41.42 0.32 6487 102939 1312 3.1e-141 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 922 2.1e-97 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF02086//PF04998//PF13683//PF08703//PF00665//PF05440//PF07953//PF00684 D12 class N6 adenine-specific DNA methyltransferase//RNA polymerase Rpb1, domain 5//Integrase core domain//PLC-beta C terminal//Integrase core domain//Tetrahydromethanopterin S-methyltransferase subunit B//Clostridium neurotoxin, N-terminal receptor binding//DnaJ central domain GO:0015074//GO:0006306//GO:0016042//GO:0006206//GO:0006144//GO:0051609//GO:0006351//GO:0015948//GO:0009395//GO:0046656//GO:0009405//GO:0007165//GO:0046339//GO:0032775 DNA integration//DNA methylation//lipid catabolic process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//inhibition of neurotransmitter uptake//transcription, DNA-templated//methanogenesis//phospholipid catabolic process//folic acid biosynthetic process//pathogenesis//signal transduction//diacylglycerol metabolic process//DNA methylation on adenine GO:0005509//GO:0031072//GO:0003677//GO:0004435//GO:0050827//GO:0009007//GO:0051082//GO:0004222//GO:0003899//GO:0030269 calcium ion binding//heat shock protein binding//DNA binding//phosphatidylinositol phospholipase C activity//toxin receptor binding//site-specific DNA-methyltransferase (adenine-specific) activity//unfolded protein binding//metalloendopeptidase activity//DNA-directed RNA polymerase activity//tetrahydromethanopterin S-methyltransferase activity GO:0005576//GO:0005730//GO:0016021 extracellular region//nucleolus//integral component of membrane KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.55161 BP_3 34.85 3.87 726 546684200 ERL93905.1 256 9.7e-20 hypothetical protein D910_11191 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55164 BP_3 40.64 0.60 3539 270011744 EFA08192.1 887 3.2e-92 hypothetical protein TcasGA2_TC005819 [Tribolium castaneum] -- -- -- -- -- K10773 NTH endonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K10773 Q2KID2 739 1.9e-76 Endonuclease III-like protein 1 OS=Bos taurus GN=NTHL1 PE=2 SV=1 PF00633//PF09398//PF00730//PF16045 Helix-hairpin-helix motif//FOP N terminal dimerisation domain//HhH-GPD superfamily base excision DNA repair protein//LisH GO:0034453//GO:0006284 microtubule anchoring//base-excision repair GO:0005515//GO:0003677 protein binding//DNA binding GO:0005815 microtubule organizing center KOG1921 Endonuclease III Cluster-8309.55165 BP_3 17.00 0.63 1585 478257377 ENN77535.1 412 1.7e-37 hypothetical protein YQE_05983, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0006118//GO:0006570//GO:0055114 obsolete electron transport//tyrosine metabolic process//oxidation-reduction process GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.55166 BP_3 552.53 39.73 962 478259434 ENN79324.1 586 7.0e-58 hypothetical protein YQE_04233, partial [Dendroctonus ponderosae]>gi|546675175|gb|ERL86411.1| hypothetical protein D910_03818 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55171 BP_3 24.21 0.74 1866 667281488 XP_008574444.1 798 3.5e-82 PREDICTED: zinc finger protein 778-like [Galeopterus variegatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 767 5.7e-80 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF01155//PF13465//PF00096//PF07776//PF00935//PF13912 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Ribosomal protein L44//C2H2-type zinc finger GO:0042254//GO:0006464//GO:0006412 ribosome biogenesis//cellular protein modification process//translation GO:0008270//GO:0003735//GO:0046872//GO:0016151 zinc ion binding//structural constituent of ribosome//metal ion binding//nickel cation binding GO:0005622//GO:0005840//GO:0005634 intracellular//ribosome//nucleus -- -- Cluster-8309.55173 BP_3 71.00 1.08 3462 270005481 EFA01929.1 2901 0.0e+00 hypothetical protein TcasGA2_TC007543 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7P9 823 3.4e-86 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF04926//PF00098//PF09668 Poly(A) polymerase predicted RNA binding domain//Zinc knuckle//Aspartyl protease GO:0043631//GO:0006508 RNA polyadenylation//proteolysis GO:0004190//GO:0003676//GO:0003723//GO:0008270 aspartic-type endopeptidase activity//nucleic acid binding//RNA binding//zinc ion binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.55178 BP_3 1240.40 51.04 1463 91085557 XP_966821.1 987 3.4e-104 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 409 1.5e-38 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13414//PF00254//PF13371//PF13181//PF00515 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.55180 BP_3 303.81 11.93 1519 91085557 XP_966821.1 987 3.5e-104 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 409 1.5e-38 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13414//PF00254//PF13371//PF13181//PF00515 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.55185 BP_3 103.81 1.40 3871 91093355 XP_969078.1 1092 6.0e-116 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IWG1 433 6.4e-41 WD repeat-containing protein 63 OS=Homo sapiens GN=WDR63 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.55188 BP_3 261.46 8.18 1833 91090512 XP_969653.1 942 7.0e-99 PREDICTED: transmembrane protein 177 [Tribolium castaneum]>gi|270013871|gb|EFA10319.1| hypothetical protein TcasGA2_TC012535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q53S58 309 7.2e-27 Transmembrane protein 177 OS=Homo sapiens GN=TMEM177 PE=2 SV=1 PF02065 Melibiase GO:0006012//GO:0001575//GO:0046486//GO:0005975 galactose metabolic process//globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0004557 alpha-galactosidase activity -- -- -- -- Cluster-8309.55189 BP_3 21.90 0.73 1743 91090512 XP_969653.1 809 1.8e-83 PREDICTED: transmembrane protein 177 [Tribolium castaneum]>gi|270013871|gb|EFA10319.1| hypothetical protein TcasGA2_TC012535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q53S58 308 9.0e-27 Transmembrane protein 177 OS=Homo sapiens GN=TMEM177 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5519 BP_3 26.85 1.91 969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55193 BP_3 15.35 0.34 2438 642937199 XP_008198736.1 2686 5.5e-301 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 2.25303e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1554 4.1e-171 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00454//PF00787//PF00168 Phosphatidylinositol 3- and 4-kinase//PX domain//C2 domain -- -- GO:0035091//GO:0005515//GO:0016773 phosphatidylinositol binding//protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.55194 BP_3 67.20 0.38 8706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55196 BP_3 16.00 0.64 1492 164698402 NP_001106938.1 1444 3.5e-157 optix [Tribolium castaneum]>gi|162417305|emb|CAP58434.1| Optix [Tribolium castaneum]>gi|270002745|gb|EEZ99192.1| sine oculis-related homeobox 3 [Tribolium castaneum] 683895024 XM_009101655.1 233 1.99841e-116 PREDICTED: Serinus canaria SIX homeobox 6 (SIX6), mRNA K19473 SIX3_6, OPTIX homeobox protein SIX3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K19473 Q95RW8 905 4.6e-96 Protein Optix OS=Drosophila melanogaster GN=Optix PE=2 SV=1 PF05920//PF01381//PF00046 Homeobox KN domain//Helix-turn-helix//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- KOG0775 Transcription factor SIX and related HOX domain proteins Cluster-8309.55197 BP_3 8.45 0.53 1064 164698402 NP_001106938.1 237 2.3e-17 optix [Tribolium castaneum]>gi|162417305|emb|CAP58434.1| Optix [Tribolium castaneum]>gi|270002745|gb|EEZ99192.1| sine oculis-related homeobox 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55198 BP_3 19.26 0.70 1612 642930146 XP_008196271.1 1599 4.0e-175 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X5 [Tribolium castaneum] 189164165 EU545256.1 263 4.55143e-133 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1228 1.7e-133 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.552 BP_3 5.13 0.73 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55200 BP_3 68.39 1.98 1956 478260286 ENN80038.1 1121 1.3e-119 hypothetical protein YQE_03515, partial [Dendroctonus ponderosae] -- -- -- -- -- K03660 OGG1 N-glycosylase/DNA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K03660 O70249 689 6.7e-71 N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1 PF07934//PF00730//PF00633 8-oxoguanine DNA glycosylase, N-terminal domain//HhH-GPD superfamily base excision DNA repair protein//Helix-hairpin-helix motif GO:0006289//GO:0006308//GO:0006285//GO:0006281//GO:0006284 nucleotide-excision repair//DNA catabolic process//base-excision repair, AP site formation//DNA repair//base-excision repair GO:0003684//GO:0008534//GO:0003677 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//DNA binding -- -- KOG2875 8-oxoguanine DNA glycosylase Cluster-8309.55201 BP_3 56.40 1.14 2671 478260286 ENN80038.1 1036 1.3e-109 hypothetical protein YQE_03515, partial [Dendroctonus ponderosae] -- -- -- -- -- K03660 OGG1 N-glycosylase/DNA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K03660 O70249 633 2.8e-64 N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1 PF13895//PF07934//PF00730//PF00633 Immunoglobulin domain//8-oxoguanine DNA glycosylase, N-terminal domain//HhH-GPD superfamily base excision DNA repair protein//Helix-hairpin-helix motif GO:0006308//GO:0006289//GO:0006285//GO:0006281//GO:0006284 DNA catabolic process//nucleotide-excision repair//base-excision repair, AP site formation//DNA repair//base-excision repair GO:0003684//GO:0008534//GO:0005515//GO:0003677 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//protein binding//DNA binding -- -- KOG2875 8-oxoguanine DNA glycosylase Cluster-8309.55202 BP_3 2.00 0.32 593 478262136 ENN81018.1 161 8.2e-09 hypothetical protein YQE_02572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.55206 BP_3 57.95 0.42 6909 642936341 XP_008198402.1 3316 0.0e+00 PREDICTED: adenylate kinase 9-like [Tribolium castaneum]>gi|270013134|gb|EFA09582.1| hypothetical protein TcasGA2_TC011699 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TCS8 983 1.9e-104 Adenylate kinase 9 OS=Homo sapiens GN=AK9 PE=1 SV=2 PF01695//PF07728//PF05496//PF00004//PF02224//PF00931//PF00910 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//NB-ARC domain//RNA helicase GO:0006139//GO:0006281//GO:0006206//GO:0006310 nucleobase-containing compound metabolic process//DNA repair//pyrimidine nucleobase metabolic process//DNA recombination GO:0005524//GO:0003723//GO:0043531//GO:0016887//GO:0004127//GO:0009378//GO:0003724 ATP binding//RNA binding//ADP binding//ATPase activity//cytidylate kinase activity//four-way junction helicase activity//RNA helicase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork -- -- Cluster-8309.55207 BP_3 6.00 0.48 899 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55208 BP_3 150.27 1.27 5980 642924788 XP_008194040.1 2680 6.7e-300 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 Q25637 1503 8.3e-165 Period circadian protein OS=Periplaneta americana GN=per PE=2 SV=2 PF00516//PF08447//PF08926//PF00989//PF01554 Envelope glycoprotein GP120//PAS fold//Domain of unknown function (DUF1908)//PAS fold//MatE GO:0006355//GO:0055085//GO:0009069//GO:0006468//GO:0006810//GO:0015893//GO:0006855//GO:0016310 regulation of transcription, DNA-templated//transmembrane transport//serine family amino acid metabolic process//protein phosphorylation//transport//drug transport//drug transmembrane transport//phosphorylation GO:0004674//GO:0005524//GO:0015238//GO:0000287//GO:0015297//GO:0005515 protein serine/threonine kinase activity//ATP binding//drug transmembrane transporter activity//magnesium ion binding//antiporter activity//protein binding GO:0016020//GO:0019031 membrane//viral envelope KOG3753 Circadian clock protein period Cluster-8309.55211 BP_3 693.77 5.33 6560 642938343 XP_008192909.1 4571 0.0e+00 PREDICTED: uncharacterized protein LOC103312885 [Tribolium castaneum] -- -- -- -- -- K11494 RCBTB RCC1 and BTB domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11494 Q5DX34 317 3.1e-27 X-linked retinitis pigmentosa GTPase regulator homolog OS=Caenorhabditis elegans GN=glo-4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.55212 BP_3 17.91 0.38 2544 478256499 ENN76683.1 2453 6.0e-274 hypothetical protein YQE_06749, partial [Dendroctonus ponderosae] 815821208 XM_012376424.1 182 7.71737e-88 PREDICTED: Linepithema humile probable glutamine--tRNA ligase (LOC105677665), mRNA K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 2180 1.1e-243 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 PF03950//PF00749//PF04558//PF04557//PF07499 tRNA synthetases class I (E and Q), anti-codon binding domain//tRNA synthetases class I (E and Q), catalytic domain//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//RuvA, C-terminal domain GO:0006281//GO:0006418//GO:0006310//GO:0006425//GO:0043039 DNA repair//tRNA aminoacylation for protein translation//DNA recombination//glutaminyl-tRNA aminoacylation//tRNA aminoacylation GO:0005524//GO:0000166//GO:0004819//GO:0009378//GO:0016876//GO:0004812 ATP binding//nucleotide binding//glutamine-tRNA ligase activity//four-way junction helicase activity//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity GO:0005657//GO:0009379//GO:0005737 replication fork//Holliday junction helicase complex//cytoplasm KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.55213 BP_3 38.51 0.61 3320 270015450 EFA11898.1 580 1.2e-56 hypothetical protein TcasGA2_TC001429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00589 Phage integrase family GO:0006310//GO:0015074 DNA recombination//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.55216 BP_3 280.18 2.70 5302 751224154 XP_011165403.1 320 2.7e-26 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08103 Uperin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.5522 BP_3 1.88 0.84 398 642914964 XP_008190461.1 431 2.7e-40 PREDICTED: helicase POLQ-like [Tribolium castaneum] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 307 2.7e-27 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF04566 RNA polymerase Rpb2, domain 4 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.55220 BP_3 46.33 0.34 6954 91078738 XP_967649.1 297 1.6e-23 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DC39 181 1.9e-11 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.55222 BP_3 26.00 1.46 1151 121582324 NP_001073566.1 259 6.9e-20 cuticular protein analogous to peritrophins 3-B precursor [Tribolium castaneum]>gi|119387886|gb|ABL73928.1| obstractor B [Tribolium castaneum]>gi|270000881|gb|EEZ97328.1| hypothetical protein TcasGA2_TC011139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.55223 BP_3 36.39 0.44 4317 827556941 XP_012549781.1 1581 1.3e-172 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55229 BP_3 76.74 0.47 8101 642934007 XP_008197600.1 1043 6.0e-110 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] 584600633 EU595402.2 44 1.2824e-10 Drosophila virilis kl-2 1-beta dynein heavy chain mRNA, partial cds K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P0C6F1 735 1.3e-75 Dynein heavy chain 2, axonemal OS=Mus musculus GN=Dnah2 PE=2 SV=1 PF03028//PF01467//PF02993//PF00008 Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like//Minor capsid protein VI//EGF-like domain GO:0007018//GO:0007017//GO:0009058 microtubule-based movement//microtubule-based process//biosynthetic process GO:0003824//GO:0003777//GO:0005515 catalytic activity//microtubule motor activity//protein binding GO:0019028//GO:0030286//GO:0005874 viral capsid//dynein complex//microtubule KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.55231 BP_3 12.98 0.96 941 642938130 XP_008199777.1 688 1.0e-69 PREDICTED: inositol monophosphatase 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 Q5R4X0 449 2.2e-43 Inositol monophosphatase 1 OS=Pongo abelii GN=IMPA1 PE=2 SV=1 PF02399//PF00459 Origin of replication binding protein//Inositol monophosphatase family GO:0006260//GO:0046854 DNA replication//phosphatidylinositol phosphorylation GO:0005524//GO:0003688 ATP binding//DNA replication origin binding GO:0046809 replication compartment KOG2951 Inositol monophosphatase Cluster-8309.55232 BP_3 482.84 19.01 1516 546681588 ERL91652.1 2079 8.3e-231 hypothetical protein D910_08980 [Dendroctonus ponderosae] 642933909 XM_966503.2 342 5.18816e-177 PREDICTED: Tribolium castaneum pontin (LOC660254), mRNA K04499 RUVBL1, RVB1, INO80H RuvB-like protein 1 (pontin 52) http://www.genome.jp/dbget-bin/www_bget?ko:K04499 Q0IFL2 1883 1.8e-209 RuvB-like helicase 1 OS=Aedes aegypti GN=pont PE=3 SV=1 PF00004//PF01695//PF14532//PF07728//PF01057//PF05496//PF03796//PF00158//PF06068//PF02562//PF04851//PF02367//PF06414 ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//DnaB-like helicase C terminal domain//Sigma-54 interaction domain//TIP49 C-terminus//PhoH-like protein//Type III restriction enzyme, res subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin GO:0006310//GO:0002949//GO:0006355//GO:0006260//GO:0019079//GO:0006281 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA replication//viral genome replication//DNA repair GO:0009378//GO:0003678//GO:0003677//GO:0016887//GO:0016301//GO:0005524//GO:0016787//GO:0008134 four-way junction helicase activity//DNA helicase activity//DNA binding//ATPase activity//kinase activity//ATP binding//hydrolase activity//transcription factor binding GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG1942 DNA helicase, TBP-interacting protein Cluster-8309.55233 BP_3 3.74 0.35 800 642920190 XP_008192241.1 430 7.1e-40 PREDICTED: protein lin-52 homolog [Tribolium castaneum]>gi|270005293|gb|EFA01741.1| hypothetical protein TcasGA2_TC007337 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0AUQ6 254 7.5e-21 Protein lin-52 homolog OS=Danio rerio GN=lin52 PE=3 SV=1 PF10044 Retinal tissue protein GO:0006351//GO:0007049 transcription, DNA-templated//cell cycle -- -- GO:0070176 DRM complex -- -- Cluster-8309.55234 BP_3 148.69 4.17 2010 478255734 ENN75943.1 592 3.0e-58 hypothetical protein YQE_07478, partial [Dendroctonus ponderosae]>gi|546683611|gb|ERL93399.1| hypothetical protein D910_10691 [Dendroctonus ponderosae] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 Q5ZKA5 483 5.3e-47 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Gallus gallus GN=MTHFD2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.55235 BP_3 66.88 0.35 9400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55236 BP_3 8.03 0.40 1268 642932698 XP_008196949.1 688 1.4e-69 PREDICTED: uncharacterized protein LOC660251 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371//PF06367 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain GO:0030036//GO:0016043 actin cytoskeleton organization//cellular component organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- -- -- Cluster-8309.55238 BP_3 138.77 5.49 1509 642929040 XP_008195665.1 469 4.1e-44 PREDICTED: uncharacterized protein LOC662520 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLD6 143 1.1e-07 Borealin OS=Drosophila melanogaster GN=borr PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55239 BP_3 18.74 0.63 1717 642929040 XP_008195665.1 461 3.9e-43 PREDICTED: uncharacterized protein LOC662520 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLD6 143 1.2e-07 Borealin OS=Drosophila melanogaster GN=borr PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55240 BP_3 32.05 0.52 3257 642940154 XP_008194847.1 1148 1.6e-122 PREDICTED: myoneurin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 335 1.2e-29 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF02714//PF00651 Calcium-dependent channel, 7TM region, putative phosphate//BTB/POZ domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.55246 BP_3 40.37 1.68 1450 752863505 XP_011268107.1 284 1.1e-22 PREDICTED: myb/SANT-like DNA-binding domain-containing protein 4 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9CR78 182 3.0e-12 Myb/SANT-like DNA-binding domain-containing protein 3 OS=Mus musculus GN=Msantd3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55247 BP_3 13.40 0.35 2121 91075962 XP_969092.1 1413 2.0e-153 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1185 2.2e-128 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF04851//PF09177//PF07517//PF00270 Type III restriction enzyme, res subunit//Syntaxin 6, N-terminal//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0005524//GO:0016787//GO:0003677//GO:0003676 ATP binding//hydrolase activity//DNA binding//nucleic acid binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.55256 BP_3 54.00 5.02 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55258 BP_3 13.00 0.31 2288 91082769 XP_973660.1 2460 8.3e-275 PREDICTED: probable peroxisomal acyl-coenzyme A oxidase 1 [Tribolium castaneum]>gi|270015082|gb|EFA11530.1| hypothetical protein TcasGA2_TC014245 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q7KML2 1770 3.5e-196 Probable peroxisomal acyl-coenzyme A oxidase 1 OS=Drosophila melanogaster GN=CG5009 PE=1 SV=1 PF01756//PF00441//PF02770 Acyl-CoA oxidase//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0055114//GO:0006118//GO:0006635//GO:0006637 oxidation-reduction process//obsolete electron transport//fatty acid beta-oxidation//acyl-CoA metabolic process GO:0016627//GO:0050660//GO:0003997//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA oxidase activity//acyl-CoA dehydrogenase activity GO:0005777 peroxisome KOG0136 Acyl-CoA oxidase Cluster-8309.55267 BP_3 37.58 1.36 1626 642917000 XP_008199589.1 427 3.2e-39 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 186 1.2e-12 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.55268 BP_3 210.70 10.28 1280 91087755 XP_974940.1 1296 4.4e-140 PREDICTED: protein FAM50 homolog [Tribolium castaneum]>gi|270009391|gb|EFA05839.1| hypothetical protein TcasGA2_TC008623 [Tribolium castaneum] 766921690 XM_011507073.1 204 2.25634e-100 PREDICTED: Ceratosolen solmsi marchali protein FAM50 homolog (LOC105368137), transcript variant X3, mRNA K13119 FAM50, XAP5 protein FAM50 http://www.genome.jp/dbget-bin/www_bget?ko:K13119 Q299F9 1119 6.0e-121 Protein FAM50 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA11514 PE=3 SV=1 PF02196//PF04921 Raf-like Ras-binding domain//XAP5, circadian clock regulator GO:0007165 signal transduction GO:0005057 receptor signaling protein activity GO:0005634 nucleus KOG2894 Uncharacterized conserved protein XAP-5 Cluster-8309.5527 BP_3 16.71 0.34 2679 270012930 EFA09378.1 160 4.9e-08 hypothetical protein TcasGA2_TC001939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- -- -- Cluster-8309.55270 BP_3 54.72 2.49 1351 642928603 XP_008199974.1 477 4.3e-45 PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum]>gi|642928605|ref|XP_008199975.1| PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum]>gi|642928607|ref|XP_008199976.1| PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum]>gi|642928609|ref|XP_008199977.1| PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6XXX9 139 2.7e-07 5-hydroxytryptamine receptor 1A OS=Canis familiaris GN=HTR1A PE=3 SV=1 PF05434//PF00895//PF00001//PF07127 TMEM9//ATP synthase protein 8//7 transmembrane receptor (rhodopsin family)//Late nodulin protein GO:0007186//GO:0009878//GO:0015986//GO:0015992 G-protein coupled receptor signaling pathway//nodule morphogenesis//ATP synthesis coupled proton transport//proton transport GO:0004930//GO:0015078//GO:0046872 G-protein coupled receptor activity//hydrogen ion transmembrane transporter activity//metal ion binding GO:0016021//GO:0000276 integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.55272 BP_3 6.00 7.22 321 307187889 EFN72812.1 136 3.5e-06 hypothetical protein EAG_02637, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55273 BP_3 10.67 0.91 855 642927688 XP_008196543.1 453 1.6e-42 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 248 4.0e-20 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF02038//PF02179//PF13855//PF13516 ATP1G1/PLM/MAT8 family//BAG domain//Leucine rich repeat//Leucine Rich repeat GO:0006811 ion transport GO:0051087//GO:0005216//GO:0005515 chaperone binding//ion channel activity//protein binding GO:0016020 membrane KOG2123 Uncharacterized conserved protein Cluster-8309.55277 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55278 BP_3 18.00 0.35 2786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55279 BP_3 10.00 0.38 1566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55280 BP_3 22.81 1.00 1391 546684929 ERL94511.1 162 1.5e-08 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.55281 BP_3 11.75 0.36 1855 332374316 AEE62299.1 329 8.5e-28 unknown [Dendroctonus ponderosae]>gi|478255157|gb|ENN75386.1| hypothetical protein YQE_07938, partial [Dendroctonus ponderosae]>gi|546677194|gb|ERL88076.1| hypothetical protein D910_05465 [Dendroctonus ponderosae] -- -- -- -- -- K01764 E4.4.1.17 cytochrome c heme-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01764 Q5F339 142 1.7e-07 Cytochrome c-type heme lyase OS=Gallus gallus GN=HCCS PE=2 SV=1 PF01265 Cytochrome c/c1 heme lyase GO:0015994 chlorophyll metabolic process GO:0004408 holocytochrome-c synthase activity GO:0005739 mitochondrion KOG3996 Holocytochrome c synthase/heme-lyase Cluster-8309.55283 BP_3 30.61 1.21 1513 534293303 AGU16824.1 1225 8.8e-132 S-adenosyl- L-homocysteine hydrolase [Leptinotarsa decemlineata]>gi|859132839|gb|AKO63328.1| S-adenosylhomocysteine hydrolase 2 [Leptinotarsa decemlineata] 821118450 XM_004463226.2 126 6.1358e-57 PREDICTED: Dasypus novemcinctus adenosylhomocysteinase-like 2 (AHCYL2), transcript variant X6, mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 O43865 1075 9.0e-116 Adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2 PF02882//PF02826//PF13241//PF16683//PF07851//PF00208//PF02254//PF07992//PF05221//PF02966 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Putative NAD(P)-binding//Transglutaminase elicitor//TMPIT-like protein//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase//S-adenosyl-L-homocysteine hydrolase//Mitosis protein DIM1 GO:0006730//GO:0000398//GO:0006779//GO:0055114//GO:0009396//GO:0046487//GO:0006555//GO:0006520//GO:0019354//GO:0006813 one-carbon metabolic process//mRNA splicing, via spliceosome//porphyrin-containing compound biosynthetic process//oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//methionine metabolic process//cellular amino acid metabolic process//siroheme biosynthetic process//potassium ion transport GO:0016755//GO:0004488//GO:0043115//GO:0003824//GO:0016491//GO:0004013//GO:0051287 transferase activity, transferring amino-acyl groups//methylenetetrahydrofolate dehydrogenase (NADP+) activity//precorrin-2 dehydrogenase activity//catalytic activity//oxidoreductase activity//adenosylhomocysteinase activity//NAD binding GO:0016021//GO:0005681 integral component of membrane//spliceosomal complex KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.55285 BP_3 18.49 2.84 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55287 BP_3 37.12 0.78 2599 91090674 XP_974487.1 2406 1.7e-268 PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|642935631|ref|XP_008198090.1| PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|642935634|ref|XP_008198091.1| PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|270013933|gb|EFA10381.1| hypothetical protein TcasGA2_TC012612 [Tribolium castaneum] 665801709 XM_008550658.1 129 2.28783e-58 PREDICTED: Microplitis demolitor D-glucuronyl C5-epimerase (LOC103572179), mRNA K01793 GLCE heparosan-N-sulfate-glucuronate 5-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01793 Q9EPS3 1331 3.2e-145 D-glucuronyl C5-epimerase OS=Mus musculus GN=Glce PE=1 SV=2 PF09115//PF06662//PF11734 DNA polymerase III, delta subunit, C terminal//D-glucuronyl C5-epimerase C-terminus//TilS substrate C-terminal domain GO:0008033//GO:0006260//GO:0006024 tRNA processing//DNA replication//glycosaminoglycan biosynthetic process GO:0000166//GO:0016879//GO:0003887//GO:0005524//GO:0016857//GO:0003677 nucleotide binding//ligase activity, forming carbon-nitrogen bonds//DNA-directed DNA polymerase activity//ATP binding//racemase and epimerase activity, acting on carbohydrates and derivatives//DNA binding GO:0005737//GO:0042575//GO:0009360//GO:0016021 cytoplasm//DNA polymerase complex//DNA polymerase III complex//integral component of membrane KOG3760 Heparan sulfate-glucuronic acid C5-epimerase Cluster-8309.55289 BP_3 905.13 23.67 2135 546681664 ERL91712.1 1305 6.6e-141 hypothetical protein D910_09039 [Dendroctonus ponderosae] -- -- -- -- -- K15280 SLC35C2 solute carrier family 35, member C2 http://www.genome.jp/dbget-bin/www_bget?ko:K15280 Q9NQQ7 658 2.9e-67 Solute carrier family 35 member C2 OS=Homo sapiens GN=SLC35C2 PE=1 SV=2 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1443 Predicted integral membrane protein Cluster-8309.55290 BP_3 8.83 0.34 1537 546681664 ERL91712.1 384 3.0e-34 hypothetical protein D910_09039 [Dendroctonus ponderosae] -- -- -- -- -- K15280 SLC35C2 solute carrier family 35, member C2 http://www.genome.jp/dbget-bin/www_bget?ko:K15280 Q9NQQ7 178 9.4e-12 Solute carrier family 35 member C2 OS=Homo sapiens GN=SLC35C2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1443 Predicted integral membrane protein Cluster-8309.55293 BP_3 62.78 1.68 2091 642933178 XP_008197290.1 1648 1.1e-180 PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X2 [Tribolium castaneum] 430763429 JQ753065.1 49 5.43606e-14 Aedes aegypti strain Liverpool Kir1 channel protein mRNA, complete cds K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 Q92806 911 1.3e-96 G protein-activated inward rectifier potassium channel 3 OS=Homo sapiens GN=KCNJ9 PE=2 SV=2 PF01007//PF00520//PF10716 Inward rectifier potassium channel//Ion transport protein//NADH dehydrogenase transmembrane subunit GO:0006811//GO:0055114//GO:0006118//GO:0006813//GO:0055085 ion transport//oxidation-reduction process//obsolete electron transport//potassium ion transport//transmembrane transport GO:0016655//GO:0005216//GO:0005242 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//ion channel activity//inward rectifier potassium channel activity GO:0008076//GO:0016020//GO:0016021 voltage-gated potassium channel complex//membrane//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.55298 BP_3 309.03 15.21 1271 642931053 XP_973827.2 1132 4.5e-121 PREDICTED: isoaspartyl peptidase/L-asparaginase [Tribolium castaneum] -- -- -- -- -- K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q29I93 723 4.9e-75 Probable isoaspartyl peptidase/L-asparaginase GA20639 OS=Drosophila pseudoobscura pseudoobscura GN=GA20639 PE=3 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1592 Asparaginase Cluster-8309.55299 BP_3 25.15 1.80 967 642926319 XP_008194875.1 487 2.1e-46 PREDICTED: bicaudal D-related protein homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K16756 CCDC64 coiled-coil domain-containing protein 64 http://www.genome.jp/dbget-bin/www_bget?ko:K16756 Q8SWR2 272 7.4e-23 Bicaudal D-related protein homolog OS=Drosophila melanogaster GN=CG17365 PE=2 SV=1 PF10186//PF01920//PF01544//PF02601 Vacuolar sorting 38 and autophagy-related subunit 14//Prefoldin subunit//CorA-like Mg2+ transporter protein//Exonuclease VII, large subunit GO:0030001//GO:0055085//GO:0006457//GO:0010508//GO:0006308 metal ion transport//transmembrane transport//protein folding//positive regulation of autophagy//DNA catabolic process GO:0008855//GO:0051082//GO:0046873 exodeoxyribonuclease VII activity//unfolded protein binding//metal ion transmembrane transporter activity GO:0009318//GO:0016020//GO:0016272 exodeoxyribonuclease VII complex//membrane//prefoldin complex -- -- Cluster-8309.55300 BP_3 5.73 0.42 945 91078046 XP_971013.1 320 4.8e-27 PREDICTED: protein inscuteable homolog [Tribolium castaneum]>gi|270002309|gb|EEZ98756.1| hypothetical protein TcasGA2_TC001320 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3HNM7 129 2.8e-06 Protein inscuteable homolog OS=Mus musculus GN=Insc PE=1 SV=2 PF00514 Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55301 BP_3 75.10 1.08 3628 642929960 XP_008196043.1 1073 8.9e-114 PREDICTED: uncharacterized protein LOC661554 [Tribolium castaneum] -- -- -- -- -- K07819 B3GALT1 beta-1,3-galactosyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07819 O54904 431 1.0e-40 Beta-1,3-galactosyltransferase 1 OS=Mus musculus GN=B3galt1 PE=2 SV=2 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane -- -- Cluster-8309.55302 BP_3 33.20 1.51 1353 642921027 XP_008192660.1 749 1.2e-76 PREDICTED: protein kinase C-binding protein NELL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1A5Y0 275 4.7e-23 Protein kinase C-binding protein NELL2 OS=Danio rerio GN=nell2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55304 BP_3 38.98 1.51 1533 546680804 ERL91010.1 1646 1.4e-180 hypothetical protein D910_08352 [Dendroctonus ponderosae] -- -- -- -- -- K16943 SEPT4 septin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16943 Q5R6R7 1146 5.3e-124 Septin-4 OS=Pongo abelii GN=SEPT4 PE=2 SV=1 PF02421//PF01926//PF08477//PF00735//PF00071//PF04548//PF03193//PF00005 Ferrous iron transport protein B//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//Ras family//AIG1 family//Protein of unknown function, DUF258//ABC transporter GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0016887//GO:0005524//GO:0015093//GO:0003924 GTP binding//ATPase activity//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.55307 BP_3 3.00 0.36 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55309 BP_3 265.73 6.37 2301 478258940 ENN78915.1 1193 6.9e-128 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 Q8CHP8 606 3.3e-61 Phosphoglycolate phosphatase OS=Mus musculus GN=Pgp PE=1 SV=1 PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.55310 BP_3 14.09 0.78 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55311 BP_3 65.50 2.13 1776 478252150 ENN72578.1 212 3.0e-14 hypothetical protein YQE_10679, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55313 BP_3 4.60 0.34 936 642916163 XP_008190912.1 310 6.9e-26 PREDICTED: abhydrolase domain-containing protein 16A [Tribolium castaneum]>gi|270003703|gb|EFA00151.1| hypothetical protein TcasGA2_TC002972 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95870 172 2.8e-11 Abhydrolase domain-containing protein 16A OS=Homo sapiens GN=ABHD16A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55315 BP_3 7.31 0.94 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10766 Multidrug efflux pump-associated protein AcrZ GO:0015893//GO:0006855 drug transport//drug transmembrane transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.55316 BP_3 47.55 0.64 3873 91092132 XP_975744.1 3438 0.0e+00 PREDICTED: transportin-1 [Tribolium castaneum] 641677337 XM_001948935.3 163 4.30394e-77 PREDICTED: Acyrthosiphon pisum transportin-1 (LOC100169518), mRNA K18752 TNPO1 transportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K18752 Q8BFY9 3032 0.0e+00 Transportin-1 OS=Mus musculus GN=Tnpo1 PE=1 SV=2 PF02985//PF03810//PF01602//PF00514 HEAT repeat//Importin-beta N-terminal domain//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding GO:0030117 membrane coat KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) Cluster-8309.55318 BP_3 12.48 1.19 796 91084075 XP_967986.1 498 9.3e-48 PREDICTED: regucalcin [Tribolium castaneum]>gi|270006685|gb|EFA03133.1| hypothetical protein TcasGA2_TC013045 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 274 3.6e-23 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55319 BP_3 2.00 0.51 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55320 BP_3 66.16 1.76 2101 332375354 AEE62818.1 479 3.9e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3T0W3 287 2.9e-24 E3 ubiquitin-protein ligase RNF181 OS=Bos taurus GN=RNF181 PE=2 SV=1 PF13639//PF12678//PF17123//PF14634//PF12861//PF00097//PF17122 Ring finger domain//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.55321 BP_3 555.71 13.66 2253 270014745 EFA11193.1 1460 7.4e-159 hypothetical protein TcasGA2_TC004801 [Tribolium castaneum] 642911832 XM_008202543.1 270 8.22242e-137 PREDICTED: Tribolium castaneum endophilin-A (LOC661913), transcript variant X2, mRNA K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I190 1146 7.8e-124 Endophilin-A OS=Drosophila virilis GN=endoA PE=3 SV=1 PF03114 BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation Cluster-8309.55326 BP_3 29.68 0.77 2160 642936860 XP_008197931.1 2345 1.7e-261 PREDICTED: sodium- and chloride-dependent glycine transporter 1-like [Tribolium castaneum] -- -- -- -- -- K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 Q9Y345 1104 5.6e-119 Sodium- and chloride-dependent glycine transporter 2 OS=Homo sapiens GN=SLC6A5 PE=1 SV=3 PF11427//PF00209 Tc3 transposase//Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328//GO:0003677 neurotransmitter:sodium symporter activity//DNA binding GO:0016021 integral component of membrane KOG3660 Sodium-neurotransmitter symporter Cluster-8309.55327 BP_3 58.01 0.75 4028 270003759 EFA00207.1 1136 4.9e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.80606e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.55330 BP_3 25.70 3.75 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55331 BP_3 5.00 0.71 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55342 BP_3 207.84 2.15 4950 642929233 XP_008195746.1 1038 1.4e-109 PREDICTED: claspin homolog [Tribolium castaneum]>gi|270009673|gb|EFA06121.1| hypothetical protein TcasGA2_TC008964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRB5 380 1.1e-34 Claspin homolog OS=Drosophila melanogaster GN=CG32251 PE=1 SV=1 PF07827 KNTase C-terminal domain GO:0046677 response to antibiotic GO:0016779 nucleotidyltransferase activity -- -- KOG4156 Claspin, protein mediating phosphorylation and activation of Chk1 protein kinase in the DNA replication checkpoint response Cluster-8309.55344 BP_3 129.11 9.91 920 808147467 XP_012174812.1 762 2.6e-78 PREDICTED: potassium channel subfamily T member 2 isoform X1 [Bombus terrestris]>gi|808147469|ref|XP_012174813.1| PREDICTED: potassium channel subfamily T member 2 isoform X1 [Bombus terrestris] 755849387 XM_011295091.1 96 1.74854e-40 PREDICTED: Musca domestica potassium channel subfamily T member 2 (LOC101895809), transcript variant X3, mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q5JUK3 376 6.2e-35 Potassium channel subfamily T member 1 OS=Homo sapiens GN=KCNT1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55348 BP_3 21.39 0.73 1706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55358 BP_3 59.01 1.40 2320 642916559 XP_008191693.1 1581 7.1e-173 PREDICTED: uncharacterized protein LOC103312554 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55360 BP_3 37.00 0.75 2661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55369 BP_3 11.99 0.97 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55370 BP_3 72.17 0.77 4832 270000843 EEZ97290.1 1515 6.6e-165 hypothetical protein TcasGA2_TC011095 [Tribolium castaneum] 642937273 XM_008200545.1 236 1.41344e-117 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X2, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 763 4.3e-79 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF16867//PF01369 Dimethlysulfonioproprionate lyase//Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086//GO:0047869 ARF guanyl-nucleotide exchange factor activity//dimethylpropiothetin dethiomethylase activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.55371 BP_3 12.03 0.41 1690 642926488 XP_008191976.1 1675 6.5e-184 PREDICTED: probable ATP-dependent RNA helicase kurz [Tribolium castaneum]>gi|270009095|gb|EFA05543.1| hypothetical protein TcasGA2_TC015731 [Tribolium castaneum] -- -- -- -- -- K14780 DHX37, DHR1 ATP-dependent RNA helicase DHX37/DHR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14780 O46072 1195 1.2e-129 Probable ATP-dependent RNA helicase kurz OS=Drosophila melanogaster GN=kz PE=1 SV=1 PF04408 Helicase associated domain (HA2) -- -- GO:0003676//GO:0004386//GO:0005524//GO:0008026 nucleic acid binding//helicase activity//ATP binding//ATP-dependent helicase activity -- -- KOG0926 DEAH-box RNA helicase Cluster-8309.55372 BP_3 234.05 1.95 6087 642913346 XP_967720.2 5481 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270002774|gb|EEZ99221.1| hypothetical protein TcasGA2_TC000625 [Tribolium castaneum] 759033122 XM_011346822.1 60 1.22768e-19 PREDICTED: Cerapachys biroi chaoptin-like (LOC105283719), transcript variant X2, mRNA -- -- -- -- P12024 466 1.5e-44 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF13855//PF00041 Leucine Rich Repeat//Leucine rich repeat//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.55374 BP_3 47.40 0.59 4143 642913995 XP_008201506.1 1146 3.5e-122 PREDICTED: uncharacterized protein CG1785 isoform X1 [Tribolium castaneum]>gi|270001623|gb|EEZ98070.1| hypothetical protein TcasGA2_TC000477 [Tribolium castaneum] -- -- -- -- -- K14825 ERP2 protein ERP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14825 Q9W3C2 663 1.5e-67 Uncharacterized protein CG1785 OS=Drosophila melanogaster GN=CG1785 PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG2823 Cellular protein (glioma tumor suppressor candidate region gene 2) Cluster-8309.55375 BP_3 623.60 7.29 4412 642913995 XP_008201506.1 1173 2.8e-125 PREDICTED: uncharacterized protein CG1785 isoform X1 [Tribolium castaneum]>gi|270001623|gb|EEZ98070.1| hypothetical protein TcasGA2_TC000477 [Tribolium castaneum] -- -- -- -- -- K14825 ERP2 protein ERP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14825 Q9W3C2 678 2.8e-69 Uncharacterized protein CG1785 OS=Drosophila melanogaster GN=CG1785 PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG2823 Cellular protein (glioma tumor suppressor candidate region gene 2) Cluster-8309.55378 BP_3 58.65 11.71 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55382 BP_3 9.06 0.81 830 91094031 XP_967783.1 397 5.0e-36 PREDICTED: protein germ cell-less [Tribolium castaneum]>gi|270004797|gb|EFA01245.1| germ cell-less [Tribolium castaneum] -- -- -- -- -- K10485 BTBD13, GMCL1, GCL BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1) http://www.genome.jp/dbget-bin/www_bget?ko:K10485 Q8NEA9 250 2.3e-20 Putative germ cell-less protein-like 1-like OS=Homo sapiens GN=GMCL1P1 PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4682 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.55383 BP_3 11.11 0.73 1022 91088039 XP_974446.1 529 3.0e-51 PREDICTED: erlin-1 [Tribolium castaneum]>gi|270012079|gb|EFA08527.1| hypothetical protein TcasGA2_TC006180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91X78 463 5.6e-45 Erlin-1 OS=Mus musculus GN=Erlin1 PE=1 SV=1 PF00318 Ribosomal protein S2 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2962 Prohibitin-related membrane protease subunits Cluster-8309.55386 BP_3 183.22 3.03 3208 642928537 XP_008195365.1 949 1.9e-99 PREDICTED: serine protease easter-like [Tribolium castaneum]>gi|270011008|gb|EFA07456.1| serine protease P95 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 441 6.3e-42 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF07167 Trypsin//Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus GO:0042619//GO:0006508 poly-hydroxybutyrate biosynthetic process//proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.55388 BP_3 54.70 1.11 2671 642928537 XP_008195365.1 798 5.1e-82 PREDICTED: serine protease easter-like [Tribolium castaneum]>gi|270011008|gb|EFA07456.1| serine protease P95 [Tribolium castaneum] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q7ZWD4 549 1.6e-54 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Danio rerio GN=uap1l1 PE=2 SV=1 PF01704//PF07657//PF00089 UTP--glucose-1-phosphate uridylyltransferase//N terminus of Notch ligand//Trypsin GO:0008152//GO:0007219//GO:0007275//GO:0006508 metabolic process//Notch signaling pathway//multicellular organismal development//proteolysis GO:0070569//GO:0004252//GO:0008236 uridylyltransferase activity//serine-type endopeptidase activity//serine-type peptidase activity GO:0016021 integral component of membrane KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.55390 BP_3 157.00 3.55 2426 478262400 ENN81071.1 841 4.8e-87 hypothetical protein YQE_02440, partial [Dendroctonus ponderosae]>gi|546673620|gb|ERL85184.1| hypothetical protein D910_02606 [Dendroctonus ponderosae] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q91YN5 675 3.5e-69 UDP-N-acetylhexosamine pyrophosphorylase OS=Mus musculus GN=Uap1 PE=1 SV=1 PF01704//PF05388//PF06344 UTP--glucose-1-phosphate uridylyltransferase//Carboxypeptidase Y pro-peptide//Parechovirus Genome-linked protein GO:0008152 metabolic process GO:0004185//GO:0070569 serine-type carboxypeptidase activity//uridylyltransferase activity GO:0005773//GO:0019015 vacuole//viral genome KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.55395 BP_3 3.00 0.44 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55398 BP_3 45.08 0.98 2500 478253028 ENN73408.1 1590 6.9e-174 hypothetical protein YQE_09970, partial [Dendroctonus ponderosae] 801389704 XM_012201966.1 126 1.02333e-56 PREDICTED: Atta cephalotes E3 ubiquitin-protein ligase CBL-B (LOC105620476), transcript variant X3, mRNA K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 P23092 1161 1.6e-125 Transforming protein cbl OS=Cas-NS-1 murine leukemia virus GN=V-CBL PE=3 SV=1 PF13639//PF02262//PF02761//PF00097//PF14634 Ring finger domain//CBL proto-oncogene N-terminal domain 1//CBL proto-oncogene N-terminus, EF hand-like domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain GO:0007166//GO:0007165 cell surface receptor signaling pathway//signal transduction GO:0004871//GO:0005509//GO:0008270//GO:0046872//GO:0005515 signal transducer activity//calcium ion binding//zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus KOG1785 Tyrosine kinase negative regulator CBL Cluster-8309.554 BP_3 26.33 1.38 1212 189237943 XP_001811459.1 935 3.0e-98 PREDICTED: WD repeat domain-containing protein 83 [Tribolium castaneum] -- -- -- -- -- K13124 MORG1 mitogen-activated protein kinase organizer 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13124 Q9DAJ4 686 9.2e-71 WD repeat domain-containing protein 83 OS=Mus musculus GN=Wdr83 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0316 Conserved WD40 repeat-containing protein Cluster-8309.55403 BP_3 67.31 0.83 4223 642935257 XP_008197935.1 2067 5.7e-229 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NRG5 1325 2.6e-144 NADPH-dependent diflavin oxidoreductase 1 OS=Xenopus laevis GN=ndor1 PE=2 SV=1 PF01344//PF00175//PF12641//PF00258//PF07646//PF00667 Kelch motif//Oxidoreductase NAD-binding domain//Flavodoxin domain//Flavodoxin//Kelch motif//FAD binding domain GO:0055114 oxidation-reduction process GO:0010181//GO:0005515//GO:0016491 FMN binding//protein binding//oxidoreductase activity -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.55410 BP_3 38.97 0.33 5911 102939 1614 2.7e-176 hypothetical protein 2 - cabbage looper transposon TED (fragment) 667676433 AE013599.5 36 2.61693e-06 Drosophila melanogaster chromosome 2R -- -- -- -- P04323 1273 3.9e-138 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.55414 BP_3 279.90 4.04 3633 642910790 XP_008193412.1 598 1.1e-58 PREDICTED: COMM domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35779 409 3.6e-38 Venom allergen 3 OS=Solenopsis richteri PE=1 SV=2 PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.55415 BP_3 27.59 0.32 4428 642930648 XP_008199209.1 1966 3.1e-217 PREDICTED: gamma-tubulin complex component 6 [Tribolium castaneum] -- -- -- -- -- K16573 TUBGCP6, GCP6 gamma-tubulin complex component 6 http://www.genome.jp/dbget-bin/www_bget?ko:K16573 Q96RT7 575 2.5e-57 Gamma-tubulin complex component 6 OS=Homo sapiens GN=TUBGCP6 PE=1 SV=3 PF04130 Spc97 / Spc98 family GO:0090063//GO:0000226 positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0005815//GO:0000922 microtubule organizing center//spindle pole KOG2001 Gamma-tubulin complex, DGRIP84/SPC97 component Cluster-8309.5542 BP_3 12.17 0.46 1563 546682615 ERL92532.1 1387 1.5e-150 hypothetical protein D910_09845 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q499P8 622 3.1e-63 RUS1 family protein C16orf58 homolog OS=Rattus norvegicus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4249 Uncharacterized conserved protein Cluster-8309.55423 BP_3 395.99 11.23 1991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55424 BP_3 78.83 2.68 1707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55425 BP_3 16.84 0.69 1475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55426 BP_3 47.39 1.17 2239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06881 RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.55427 BP_3 104.07 3.66 1662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06881 RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.55429 BP_3 565.64 3.85 7377 642928419 XP_008193779.1 1394 1.1e-150 PREDICTED: transcriptional regulator ATRX homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 F4HW51 864 1.3e-90 Protein CHROMATIN REMODELING 20 OS=Arabidopsis thaliana GN=ATRX PE=2 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.5543 BP_3 197.27 5.66 1973 91086385 XP_974771.1 2431 1.6e-271 PREDICTED: MAU2 chromatid cohesion factor homolog [Tribolium castaneum]>gi|270010289|gb|EFA06737.1| hypothetical protein TcasGA2_TC009670 [Tribolium castaneum] 808124960 XR_001098858.1 264 1.55515e-133 PREDICTED: Bombus terrestris MAU2 chromatid cohesion factor homolog (LOC100648021), transcript variant X3, misc_RNA K11266 MAU2 MAternally affected uncoordination http://www.genome.jp/dbget-bin/www_bget?ko:K11266 B1H1Z8 1672 7.0e-185 MAU2 chromatid cohesion factor homolog OS=Xenopus tropicalis GN=mau2 PE=2 SV=1 PF00515//PF13374//PF13181//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG2300 Uncharacterized conserved protein Cluster-8309.55432 BP_3 306.95 1.53 9930 642928419 XP_008193779.1 1636 1.3e-178 PREDICTED: transcriptional regulator ATRX homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 F4HW51 979 8.0e-104 Protein CHROMATIN REMODELING 20 OS=Arabidopsis thaliana GN=ATRX PE=2 SV=2 PF00176//PF02729 SNF2 family N-terminal domain//Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GO:0006520 cellular amino acid metabolic process GO:0016743//GO:0005524 carboxyl- or carbamoyltransferase activity//ATP binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.55433 BP_3 4.24 0.72 577 642918847 XP_008191612.1 143 9.8e-07 PREDICTED: uncharacterized protein LOC661835 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55435 BP_3 16.87 0.65 1548 91080243 XP_976399.1 204 2.2e-13 PREDICTED: uncharacterized protein LOC661835 isoform X2 [Tribolium castaneum]>gi|270005622|gb|EFA02070.1| hypothetical protein TcasGA2_TC007704 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.55436 BP_3 19.21 0.63 1754 642918847 XP_008191612.1 214 1.7e-14 PREDICTED: uncharacterized protein LOC661835 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55437 BP_3 12.67 0.44 1692 642918847 XP_008191612.1 214 1.7e-14 PREDICTED: uncharacterized protein LOC661835 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55438 BP_3 671.17 12.21 2941 189233695 XP_001812208.1 494 1.0e-46 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 369 1.3e-33 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.55449 BP_3 3.00 0.78 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55451 BP_3 1.00 1.89 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55452 BP_3 23.60 0.67 1981 642914318 XP_008201631.1 746 4.0e-76 PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914320|ref|XP_974744.2| PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914322|ref|XP_008201632.1| PREDICTED: F-box only protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SX24 218 2.8e-16 F-box only protein 6 OS=Bos taurus GN=FBXO6 PE=2 SV=1 PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55454 BP_3 25.05 0.66 2126 642914318 XP_008201631.1 925 7.6e-97 PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914320|ref|XP_974744.2| PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914322|ref|XP_008201632.1| PREDICTED: F-box only protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZN4 300 9.3e-26 F-box only protein 6 OS=Mus musculus GN=Fbxo6 PE=1 SV=1 PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55455 BP_3 56.11 0.71 4122 478255924 ENN76126.1 1002 1.7e-105 hypothetical protein YQE_07346, partial [Dendroctonus ponderosae]>gi|546676527|gb|ERL87521.1| hypothetical protein D910_04913 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1DH70 815 3.4e-85 Innexin shaking-B OS=Aedes aegypti GN=shakB PE=3 SV=1 PF06753//PF00876 Bradykinin//Innexin GO:0006950//GO:0007165 response to stress//signal transduction GO:0005179 hormone activity GO:0005921//GO:0005576 gap junction//extracellular region -- -- Cluster-8309.55469 BP_3 86.72 0.59 7423 270015831 EFA12279.1 835 7.2e-86 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05992 SbmA/BacA-like family GO:0006810 transport GO:0005215 transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.55473 BP_3 33.67 10.04 453 270007317 EFA03765.1 175 1.5e-10 hypothetical protein TcasGA2_TC013876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55479 BP_3 116.36 1.32 4536 642914198 XP_008201586.1 3849 0.0e+00 PREDICTED: uncharacterized protein LOC661711 isoform X2 [Tribolium castaneum] 642914197 XM_008203364.1 324 1.59838e-166 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.8e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF04904//PF00018//PF15360//PF00536//PF07647 NAB conserved region 1 (NCD1)//SH3 domain//APJ endogenous ligand//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0045892//GO:0007165 negative regulation of transcription, DNA-templated//signal transduction GO:0031704//GO:0005515//GO:0005179 apelin receptor binding//protein binding//hormone activity GO:0005634 nucleus -- -- Cluster-8309.55480 BP_3 272.59 3.15 4460 642914196 XP_008201585.1 3974 0.0e+00 PREDICTED: uncharacterized protein LOC661711 isoform X1 [Tribolium castaneum] 642914197 XM_008203364.1 679 0 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.8e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF04904//PF00018//PF15360//PF00536//PF07647 NAB conserved region 1 (NCD1)//SH3 domain//APJ endogenous ligand//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0007165//GO:0045892 signal transduction//negative regulation of transcription, DNA-templated GO:0005515//GO:0005179//GO:0031704 protein binding//hormone activity//apelin receptor binding GO:0005634 nucleus -- -- Cluster-8309.55481 BP_3 9.00 1.10 687 189240093 XP_972388.2 321 2.7e-27 PREDICTED: myosin heavy chain, clone 203 isoform X1 [Tribolium castaneum]>gi|270012237|gb|EFA08685.1| hypothetical protein TcasGA2_TC006355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0000042 protein targeting to Golgi -- -- -- -- -- -- Cluster-8309.55482 BP_3 3.00 0.40 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55484 BP_3 106.94 3.96 1595 642923720 XP_008193855.1 248 1.8e-18 PREDICTED: extended synaptotagmin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZWU7 137 5.5e-07 Extended synaptotagmin-2-B OS=Xenopus laevis GN=esyt2-b PE=2 SV=1 PF17047 Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289 lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.55494 BP_3 149.04 1.49 5116 642931650 XP_008196671.1 3492 0.0e+00 PREDICTED: death-associated protein kinase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44997 892 5.0e-94 Death-associated protein kinase dapk-1 OS=Caenorhabditis elegans GN=dapk-1 PE=2 SV=2 PF04558//PF00583//PF13508//PF00023//PF08477//PF00531//PF13606 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Ankyrin repeat//Ras of Complex, Roc, domain of DAPkinase//Death domain//Ankyrin repeat GO:0007165//GO:0042967//GO:0006418//GO:0007264 signal transduction//acyl-carrier-protein biosynthetic process//tRNA aminoacylation for protein translation//small GTPase mediated signal transduction GO:0005524//GO:0008080//GO:0005515//GO:0005525//GO:0000166//GO:0004812 ATP binding//N-acetyltransferase activity//protein binding//GTP binding//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.55496 BP_3 466.12 1.86 12391 270013018 EFA09466.1 6307 0.0e+00 hypothetical protein TcasGA2_TC010960 [Tribolium castaneum] 667677299 AE014296.5 67 3.21848e-23 Drosophila melanogaster chromosome 3L K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8WXX0 4321 0.0e+00 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 PF00910//PF02601//PF01637//PF04851//PF05418//PF00580//PF07724//PF00004//PF00437//PF03028//PF00158//PF01695//PF07728 RNA helicase//Exonuclease VII, large subunit//Archaeal ATPase//Type III restriction enzyme, res subunit//Apovitellenin I (Apo-VLDL-II)//UvrD/REP helicase N-terminal domain//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Dynein heavy chain and region D6 of dynein motor//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily) GO:0006308//GO:0006629//GO:0006355//GO:0007017//GO:0007018//GO:0006810 DNA catabolic process//lipid metabolic process//regulation of transcription, DNA-templated//microtubule-based process//microtubule-based movement//transport GO:0003724//GO:0003677//GO:0003723//GO:0003777//GO:0004857//GO:0008855//GO:0016887//GO:0016787//GO:0005524//GO:0008134 RNA helicase activity//DNA binding//RNA binding//microtubule motor activity//enzyme inhibitor activity//exodeoxyribonuclease VII activity//ATPase activity//hydrolase activity//ATP binding//transcription factor binding GO:0030286//GO:0005667//GO:0005874//GO:0009318//GO:0042627 dynein complex//transcription factor complex//microtubule//exodeoxyribonuclease VII complex//chylomicron -- -- Cluster-8309.55498 BP_3 32.64 0.57 3032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55500 BP_3 103.69 0.46 11163 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15015 Spermatogenesis-associated, N-terminal GO:0007283 spermatogenesis -- -- GO:0005794 Golgi apparatus -- -- Cluster-8309.55501 BP_3 12.48 0.50 1490 546673224 ERL84874.1 303 7.1e-25 hypothetical protein D910_02297, partial [Dendroctonus ponderosae] 704338400 XM_010176089.1 39 1.39346e-08 PREDICTED: Caprimulgus carolinensis salvador family WW domain containing protein 1 (SAV1), mRNA K16686 SAV1, Sav scaffold protein salvador http://www.genome.jp/dbget-bin/www_bget?ko:K16686 Q8VEB2 252 2.4e-20 Protein salvador homolog 1 OS=Mus musculus GN=Sav1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.55506 BP_3 35.89 3.25 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55508 BP_3 438.00 5.64 4032 642919331 XP_008191828.1 2203 9.2e-245 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 1468 6.4e-161 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF07651//PF13417//PF05434 ANTH domain//Glutathione S-transferase, N-terminal domain//TMEM9 -- -- GO:0005515//GO:0005543 protein binding//phospholipid binding GO:0016021 integral component of membrane KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.55509 BP_3 282.22 27.97 778 195117344 XP_002003207.1 173 4.4e-10 GI17786 [Drosophila mojavensis]>gi|193913782|gb|EDW12649.1| GI17786 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.5551 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55510 BP_3 3358.33 22.34 7538 642932112 XP_008196860.1 3146 0.0e+00 PREDICTED: ABC transporter G family member 14 isoform X1 [Tribolium castaneum] 642932111 XM_008198638.1 779 0 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X1, mRNA -- -- -- -- Q6WV17 1239 4.3e-134 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 PF01061//PF01926//PF13304//PF00004//PF00437//PF01637//PF00005//PF05418//PF03193//PF00910//PF10662 ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Archaeal ATPase//ABC transporter//Apovitellenin I (Apo-VLDL-II)//Protein of unknown function, DUF258//RNA helicase//Ethanolamine utilisation - propanediol utilisation GO:0006629//GO:0006810//GO:0006576 lipid metabolic process//transport//cellular biogenic amine metabolic process GO:0004857//GO:0003924//GO:0003723//GO:0005524//GO:0003724//GO:0005525//GO:0016887 enzyme inhibitor activity//GTPase activity//RNA binding//ATP binding//RNA helicase activity//GTP binding//ATPase activity GO:0042627//GO:0016020 chylomicron//membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.55513 BP_3 88.45 2.76 1836 91090772 XP_969499.1 1732 1.7e-190 PREDICTED: rapamycin-insensitive companion of mTOR [Tribolium castaneum]>gi|270013969|gb|EFA10417.1| hypothetical protein TcasGA2_TC012657 [Tribolium castaneum] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 827 6.2e-87 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF05933 Fungal ATP synthase protein 8 (A6L) GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG3694 Protein required for meiosis Cluster-8309.55515 BP_3 3.00 0.47 602 768427743 XP_011554977.1 236 1.7e-17 PREDICTED: uncharacterized protein LOC105386168 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098 C2H2 zinc-finger//Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.55518 BP_3 3.00 0.55 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55520 BP_3 1.00 0.36 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55523 BP_3 171.99 6.97 1481 91082853 XP_970517.1 882 5.1e-92 PREDICTED: glyoxylate/hydroxypyruvate reductase A HPR2 [Tribolium castaneum]>gi|270007596|gb|EFA04044.1| hypothetical protein TcasGA2_TC014276 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32HN5 262 1.6e-21 Glyoxylate/hydroxypyruvate reductase A OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=ghrA PE=3 SV=2 PF02826//PF00365//PF03446 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Phosphofructokinase//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0019521//GO:0006094//GO:0006000//GO:0006013//GO:0055114//GO:0006012//GO:0006098//GO:0006096 D-gluconate metabolic process//gluconeogenesis//fructose metabolic process//mannose metabolic process//oxidation-reduction process//galactose metabolic process//pentose-phosphate shunt//glycolytic process GO:0004616//GO:0003872//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//6-phosphofructokinase activity//NAD binding GO:0005945 6-phosphofructokinase complex KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.55524 BP_3 29.70 1.16 1527 91082853 XP_970517.1 783 1.6e-80 PREDICTED: glyoxylate/hydroxypyruvate reductase A HPR2 [Tribolium castaneum]>gi|270007596|gb|EFA04044.1| hypothetical protein TcasGA2_TC014276 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32HN5 223 5.6e-17 Glyoxylate/hydroxypyruvate reductase A OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=ghrA PE=3 SV=2 PF03435//PF03446//PF00365//PF02826 Saccharopine dehydrogenase NADP binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//Phosphofructokinase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0019521//GO:0006094//GO:0006000//GO:0006013//GO:0055114//GO:0006012//GO:0006098//GO:0006096 D-gluconate metabolic process//gluconeogenesis//fructose metabolic process//mannose metabolic process//oxidation-reduction process//galactose metabolic process//pentose-phosphate shunt//glycolytic process GO:0004616//GO:0003872//GO:0016491//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//6-phosphofructokinase activity//oxidoreductase activity//NAD binding GO:0005945 6-phosphofructokinase complex KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.55525 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00444 Ribosomal protein L36 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.55531 BP_3 5.00 0.65 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55532 BP_3 5.99 1.32 511 642913586 XP_008201074.1 210 1.5e-14 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55534 BP_3 35.59 0.54 3460 478250209 ENN70712.1 1705 4.4e-187 hypothetical protein YQE_12657, partial [Dendroctonus ponderosae]>gi|546683975|gb|ERL93709.1| hypothetical protein D910_10996 [Dendroctonus ponderosae] -- -- -- -- -- K14807 DDX51, DBP6 ATP-dependent RNA helicase DDX51/DBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K14807 P26802 957 9.9e-102 Probable ATP-dependent RNA helicase Dbp73D OS=Drosophila melanogaster GN=Dbp73D PE=2 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0005524//GO:0016787//GO:0003677//GO:0003676 ATP binding//hydrolase activity//DNA binding//nucleic acid binding -- -- KOG0350 DEAD-box ATP-dependent RNA helicase Cluster-8309.55536 BP_3 37.24 1.01 2062 91087311 XP_975575.1 960 6.4e-101 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K14291 PHAX phosphorylated adapter RNA export protein http://www.genome.jp/dbget-bin/www_bget?ko:K14291 Q5ZLY0 263 1.8e-21 Phosphorylated adapter RNA export protein OS=Gallus gallus GN=PHAX PE=2 SV=1 PF02269//PF09415 Transcription initiation factor IID, 18kD subunit//CENP-S associating Centromere protein X GO:0006366//GO:0006281//GO:0051382 transcription from RNA polymerase II promoter//DNA repair//kinetochore assembly -- -- -- -- KOG3948 Mediator of U snRNA nuclear export PHAX Cluster-8309.55538 BP_3 103.35 2.70 2140 642914318 XP_008201631.1 924 1.0e-96 PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914320|ref|XP_974744.2| PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914322|ref|XP_008201632.1| PREDICTED: F-box only protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZN4 300 9.3e-26 F-box only protein 6 OS=Mus musculus GN=Fbxo6 PE=1 SV=1 PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55539 BP_3 38.00 4.20 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55540 BP_3 158.42 6.81 1413 826409641 XP_012534005.1 166 5.2e-09 PREDICTED: uncharacterized protein LOC105835358, partial [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55542 BP_3 458.02 4.75 4935 642932250 XP_008197031.1 2707 4.1e-303 PREDICTED: archipelago isoform X1 [Tribolium castaneum]>gi|642932252|ref|XP_008197033.1| PREDICTED: archipelago isoform X1 [Tribolium castaneum]>gi|270012799|gb|EFA09247.1| archipelago [Tribolium castaneum] 642932251 XM_008198811.1 516 0 PREDICTED: Tribolium castaneum archipelago (ago), transcript variant X2, mRNA K10260 FBXW7, SEL10 F-box and WD-40 domain protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10260 Q9VZF4 2155 1.7e-240 F-box/WD repeat-containing protein 7 OS=Drosophila melanogaster GN=ago PE=1 SV=1 PF06881//PF00400//PF00646//PF12937 RNA polymerase II transcription factor SIII (Elongin) subunit A//WD domain, G-beta repeat//F-box domain//F-box-like GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.55543 BP_3 27.75 0.99 1639 642922477 XP_973426.2 410 3.1e-37 PREDICTED: uncharacterized protein LOC662220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55549 BP_3 6.45 0.32 1255 553832058 AGY61427.1 1655 1.0e-181 photosystem II D1 protein [Lotharella sp. CCMP622] 761231605 KM881639.1 1020 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q06H17 1783 6.0e-198 Photosystem II protein D1 OS=Drimys granadensis GN=psbA PE=3 SV=1 PF00124 Photosynthetic reaction centre protein GO:0006118//GO:0019684//GO:0009772 obsolete electron transport//photosynthesis, light reaction//photosynthetic electron transport in photosystem II GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity -- -- -- -- Cluster-8309.55556 BP_3 6.00 0.48 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55561 BP_3 639.00 5.75 5652 270003200 EEZ99647.1 708 2.9e-71 hypothetical protein TcasGA2_TC002404 [Tribolium castaneum] -- -- -- -- -- K16768 CEP350 centrosomal protein CEP350 http://www.genome.jp/dbget-bin/www_bget?ko:K16768 Q5VT06 264 3.7e-21 Centrosome-associated protein 350 OS=Homo sapiens GN=CEP350 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55566 BP_3 41.74 0.64 3429 478259087 ENN79022.1 1288 9.9e-139 hypothetical protein YQE_04524, partial [Dendroctonus ponderosae] 195495253 XM_002095152.1 81 1.45884e-31 Drosophila yakuba GE22259 (Dyak\GE22259), partial mRNA -- -- -- -- Q9P2F6 235 5.2e-18 Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.55568 BP_3 184.26 9.83 1195 478259087 ENN79022.1 1292 1.2e-139 hypothetical protein YQE_04524, partial [Dendroctonus ponderosae] 195495253 XM_002095152.1 81 4.98904e-32 Drosophila yakuba GE22259 (Dyak\GE22259), partial mRNA -- -- -- -- Q9P2F6 235 1.8e-18 Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.55573 BP_3 1.00 14.32 234 390357282 XP_003728972.1 209 8.7e-15 PREDICTED: ankyrin repeat domain-containing protein 50-like [Strongylocentrotus purpuratus] -- -- -- -- -- K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q4UMH6 157 3.9e-10 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF03137//PF00023//PF13606 Organic Anion Transporter Polypeptide (OATP) family//Ankyrin repeat//Ankyrin repeat GO:0006810 transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020 membrane KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.55574 BP_3 1.00 37.74 212 390357282 XP_003728972.1 195 3.3e-13 PREDICTED: ankyrin repeat domain-containing protein 50-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 163 7.1e-11 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55576 BP_3 3.00 1.31 401 -- -- -- -- -- 768311758 CP010986.1 401 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55580 BP_3 412.46 8.47 2638 546683622 ERL93410.1 923 1.6e-96 hypothetical protein D910_10702 [Dendroctonus ponderosae] 676494731 XM_009068407.1 36 1.15983e-06 Lottia gigantea hypothetical protein mRNA K01057 PGLS, pgl, devB 6-phosphogluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01057 P85971 532 1.4e-52 6-phosphogluconolactonase OS=Rattus norvegicus GN=Pgls PE=1 SV=1 PF01182//PF09771 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase//Transmembrane protein 188 GO:0035307//GO:0005975 positive regulation of protein dephosphorylation//carbohydrate metabolic process -- -- GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.55581 BP_3 25.19 1.16 1342 546683622 ERL93410.1 376 2.2e-33 hypothetical protein D910_10702 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M8F7 240 5.3e-19 Nuclear envelope phosphatase-regulatory subunit 1 OS=Xenopus tropicalis GN=cnep1r1 PE=2 SV=1 PF09771 Transmembrane protein 188 GO:0035307 positive regulation of protein dephosphorylation -- -- GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.55583 BP_3 20.00 0.72 1627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55584 BP_3 9.00 1.07 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55587 BP_3 189.38 1.64 5873 642929440 XP_008195841.1 5417 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X2 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 4004 0.0e+00 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF00312//PF00520//PF16519 Ribosomal protein S15//Ion transport protein//Tetramerisation domain of TRPM GO:0006811//GO:0042254//GO:0006412//GO:0055085//GO:0051262 ion transport//ribosome biogenesis//translation//transmembrane transport//protein tetramerization GO:0005216//GO:0003735 ion channel activity//structural constituent of ribosome GO:0016020//GO:0005622//GO:0005840 membrane//intracellular//ribosome KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.55590 BP_3 447.73 7.23 3277 642925611 XP_008194640.1 2375 8.5e-265 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.4e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55594 BP_3 5.41 0.64 699 91091456 XP_972862.1 396 5.5e-36 PREDICTED: aquaporin AQPcic [Tribolium castaneum]>gi|270000980|gb|EEZ97427.1| hypothetical protein TcasGA2_TC011257 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 348 8.3e-32 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.55597 BP_3 277.07 7.23 2140 642912272 XP_008200632.1 862 1.5e-89 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 298 1.6e-25 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.55599 BP_3 14.10 0.36 2194 642912272 XP_008200632.1 833 3.6e-86 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 298 1.6e-25 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.556 BP_3 4.00 0.75 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55602 BP_3 3841.00 33.97 5742 642937187 XP_008198730.1 1103 4.7e-117 PREDICTED: cuticular protein analogous to peritrophins 1-J isoform X2 [Tribolium castaneum] 642937188 XM_008200510.1 61 3.21879e-20 PREDICTED: Tribolium castaneum cuticular protein analogous to peritrophins 1-J (Cpap1-j), transcript variant X2, mRNA -- -- -- -- Q685J3 144 3.1e-07 Mucin-17 OS=Homo sapiens GN=MUC17 PE=1 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.55603 BP_3 5.00 0.85 575 102939 378 5.5e-34 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 306 5.0e-27 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55608 BP_3 4.02 0.48 696 91095167 XP_968412.1 268 3.8e-21 PREDICTED: PRA1 family protein 3 [Tribolium castaneum]>gi|270015793|gb|EFA12241.1| hypothetical protein TcasGA2_TC016173 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-8309.55609 BP_3 22033.53 449.76 2653 332373676 AEE61979.1 761 9.8e-78 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24764 129 7.8e-06 Circadian clock-controlled protein OS=Drosophila yakuba GN=anon-3B1.2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55611 BP_3 55.40 0.57 4952 270016002 EFA12450.1 974 3.7e-102 hypothetical protein TcasGA2_TC016185 [Tribolium castaneum]>gi|270016905|gb|EFA13351.1| hypothetical protein TcasGA2_TC006959 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04799//PF00580//PF01367//PF01637//PF05829//PF04513 fzo-like conserved region//UvrD/REP helicase N-terminal domain//5'-3' exonuclease, C-terminal SAM fold//Archaeal ATPase//Adenovirus late L2 mu core protein (Protein X)//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0008053 mitochondrial fusion GO:0003924//GO:0005198//GO:0003677//GO:0005524//GO:0003824 GTPase activity//structural molecule activity//DNA binding//ATP binding//catalytic activity GO:0019013//GO:0005741//GO:0019031//GO:0019028//GO:0016021 viral nucleocapsid//mitochondrial outer membrane//viral envelope//viral capsid//integral component of membrane -- -- Cluster-8309.55617 BP_3 258.49 6.25 2286 642916217 XP_008190934.1 3030 0.0e+00 PREDICTED: calpain-C [Tribolium castaneum] 195479179 XM_002100759.1 39 2.15579e-08 Drosophila yakuba GE17262 (Dyak\GE17262), partial mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 Q9VXH6 1662 1.2e-183 Calpain-C OS=Drosophila melanogaster GN=CalpC PE=1 SV=4 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.55620 BP_3 3.17 0.33 760 478250393 ENN70888.1 406 4.1e-37 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 263 6.5e-22 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.55622 BP_3 567.23 18.06 1806 642932696 XP_008196948.1 1401 4.1e-152 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371//PF06367//PF10473 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0016043//GO:0030036 cellular component organization//actin cytoskeleton organization GO:0003779//GO:0045502//GO:0008134//GO:0017048//GO:0042803 actin binding//dynein binding//transcription factor binding//Rho GTPase binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.55627 BP_3 408.87 4.38 4790 642913192 XP_008201430.1 3754 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase SHPRH isoform X1 [Tribolium castaneum] -- -- -- -- -- K15710 SHPRH E3 ubiquitin-protein ligase SHPRH http://www.genome.jp/dbget-bin/www_bget?ko:K15710 Q149N8 1543 1.5e-169 E3 ubiquitin-protein ligase SHPRH OS=Homo sapiens GN=SHPRH PE=1 SV=2 PF00097//PF14634//PF00628//PF13639//PF13176//PF00176//PF00515//PF13374 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//PHD-finger//Ring finger domain//Tetratricopeptide repeat//SNF2 family N-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0046872//GO:0005515//GO:0008270//GO:0005524 metal ion binding//protein binding//zinc ion binding//ATP binding -- -- KOG0298 DEAD box-containing helicase-like transcription factor/DNA repair protein Cluster-8309.55628 BP_3 56.74 0.59 4903 642913192 XP_008201430.1 3649 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase SHPRH isoform X1 [Tribolium castaneum] -- -- -- -- -- K15710 SHPRH E3 ubiquitin-protein ligase SHPRH http://www.genome.jp/dbget-bin/www_bget?ko:K15710 Q7TPQ3 1469 6.0e-161 E3 ubiquitin-protein ligase SHPRH OS=Mus musculus GN=Shprh PE=1 SV=1 PF00097//PF00628//PF14634//PF13639//PF13176//PF00176//PF13374//PF00515 Zinc finger, C3HC4 type (RING finger)//PHD-finger//zinc-RING finger domain//Ring finger domain//Tetratricopeptide repeat//SNF2 family N-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0008270//GO:0005524//GO:0046872//GO:0005515 zinc ion binding//ATP binding//metal ion binding//protein binding -- -- KOG0298 DEAD box-containing helicase-like transcription factor/DNA repair protein Cluster-8309.55629 BP_3 88.67 0.92 4921 642913192 XP_008201430.1 2686 1.1e-300 PREDICTED: E3 ubiquitin-protein ligase SHPRH isoform X1 [Tribolium castaneum] -- -- -- -- -- K15710 SHPRH E3 ubiquitin-protein ligase SHPRH http://www.genome.jp/dbget-bin/www_bget?ko:K15710 Q7TPQ3 949 1.2e-100 E3 ubiquitin-protein ligase SHPRH OS=Mus musculus GN=Shprh PE=1 SV=1 PF00097//PF12678//PF00628//PF14634//PF13639//PF13176//PF00176//PF13374//PF02891//PF00515//PF12861 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//PHD-finger//zinc-RING finger domain//Ring finger domain//Tetratricopeptide repeat//SNF2 family N-terminal domain//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0005524//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//ATP binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0298 DEAD box-containing helicase-like transcription factor/DNA repair protein Cluster-8309.5563 BP_3 9.02 0.37 1471 478253658 ENN73962.1 276 9.5e-22 hypothetical protein YQE_09463, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF07535//PF00096//PF00562 zinc-finger C2H2-type//DBF zinc finger//Zinc finger, C2H2 type//RNA polymerase Rpb2, domain 6 GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0008270//GO:0003676//GO:0003899//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.55630 BP_3 1.00 0.53 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55633 BP_3 93.14 2.78 1908 642927014 XP_001810799.2 867 3.6e-90 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9J0 255 1.4e-20 Peroxisomal leader peptide-processing protease OS=Homo sapiens GN=TYSND1 PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.55637 BP_3 584.00 12.16 2607 91080945 XP_974350.1 1122 1.3e-119 PREDICTED: RNA-binding protein 28 [Tribolium castaneum]>gi|270005371|gb|EFA01819.1| hypothetical protein TcasGA2_TC007421 [Tribolium castaneum] -- -- -- -- -- K14573 NOP4, RBM28 nucleolar protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14573 Q8CGC6 481 1.2e-46 RNA-binding protein 28 OS=Mus musculus GN=Rbm28 PE=1 SV=4 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0127 Nucleolar protein fibrillarin NOP77 (RRM superfamily) Cluster-8309.55639 BP_3 9.80 0.44 1355 270009170 EFA05618.1 890 5.5e-93 hypothetical protein TcasGA2_TC015826 [Tribolium castaneum] 768423227 XM_011554208.1 242 1.79774e-121 PREDICTED: Plutella xylostella histone-lysine N-methyltransferase SETD1-like (LOC105384048), mRNA K11422 SETD1, SET1 histone-lysine N-methyltransferase SETD1 http://www.genome.jp/dbget-bin/www_bget?ko:K11422 Q5LJZ2 832 1.2e-87 Histone-lysine N-methyltransferase SETD1 OS=Drosophila melanogaster GN=Set1 PE=1 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.55640 BP_3 244.67 3.35 3807 642919490 XP_008191893.1 2927 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum]>gi|642919492|ref|XP_008191894.1| PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55643 BP_3 98.24 2.19 2455 270015916 EFA12364.1 501 1.3e-47 hypothetical protein TcasGA2_TC002070 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18583 189 8.0e-13 Protein SON OS=Homo sapiens GN=SON PE=1 SV=4 PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.5565 BP_3 204.00 2.66 3985 270013306 EFA09754.1 1835 4.3e-202 hypothetical protein TcasGA2_TC011893 [Tribolium castaneum] 642935629 XM_969375.3 750 0 PREDICTED: Tribolium castaneum uncharacterized LOC663320 (LOC663320), transcript variant X4, mRNA -- -- -- -- O60543 163 1.3e-09 Cell death activator CIDE-A OS=Homo sapiens GN=CIDEA PE=1 SV=1 PF05829//PF02017//PF06667 Adenovirus late L2 mu core protein (Protein X)//CIDE-N domain//Phage shock protein B GO:0009271//GO:0006355//GO:0006915 phage shock//regulation of transcription, DNA-templated//apoptotic process GO:0003677 DNA binding GO:0005622//GO:0019013 intracellular//viral nucleocapsid -- -- Cluster-8309.55652 BP_3 27.32 0.88 1787 642916248 XP_008190945.1 1070 9.8e-114 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642916250|ref|XP_008190946.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270003683|gb|EFA00131.1| hypothetical protein TcasGA2_TC002947 [Tribolium castaneum] -- -- -- -- -- K08202 SLC22A4_5, OCTN MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K08202 Q9VCA2 836 5.5e-88 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.55656 BP_3 3.00 0.93 446 -- -- -- -- -- 761231605 KM881639.1 446 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P0C377 422 1.4e-40 Cytochrome c biogenesis protein CcsA OS=Oryza sativa subsp. japonica GN=ccsA PE=3 SV=1 PF01578 Cytochrome C assembly protein GO:0017004 cytochrome complex assembly GO:0020037 heme binding -- -- -- -- Cluster-8309.55661 BP_3 170.91 7.28 1423 546673719 ERL85275.1 1541 1.9e-168 hypothetical protein D910_02696 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CYF5 979 1.1e-104 Williams-Beuren syndrome chromosomal region 16 protein homolog OS=Mus musculus GN=Wbscr16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.55662 BP_3 299.51 14.74 1271 827550232 XP_012547131.1 361 1.1e-31 PREDICTED: uncharacterized protein LOC101740234 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55663 BP_3 46.87 2.00 1423 642938861 XP_970628.2 843 1.6e-87 PREDICTED: uncharacterized protein LOC659208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55666 BP_3 6.00 0.37 1067 91084661 XP_967669.1 378 1.0e-33 PREDICTED: protein phosphatase 1D [Tribolium castaneum]>gi|270008629|gb|EFA05077.1| hypothetical protein TcasGA2_TC015174 [Tribolium castaneum] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 215 3.3e-16 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481//PF00570 Protein phosphatase 2C//HRDC domain GO:0006470 protein dephosphorylation GO:0003676//GO:0003824//GO:0004722//GO:0046872 nucleic acid binding//catalytic activity//protein serine/threonine phosphatase activity//metal ion binding GO:0005622//GO:0008287 intracellular//protein serine/threonine phosphatase complex KOG0698 Serine/threonine protein phosphatase Cluster-8309.55667 BP_3 373.86 21.47 1131 91077808 XP_970231.1 636 1.3e-63 PREDICTED: uncharacterized protein LOC658778 [Tribolium castaneum]>gi|270001488|gb|EEZ97935.1| hypothetical protein TcasGA2_TC000323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08917 Transforming growth factor beta receptor 2 ectodomain GO:0007178//GO:0006468//GO:0009069//GO:0016310 transmembrane receptor protein serine/threonine kinase signaling pathway//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0005026//GO:0046872 ATP binding//transforming growth factor beta receptor activity, type II//metal ion binding GO:0016020 membrane -- -- Cluster-8309.55669 BP_3 98.05 1.02 4925 91080315 XP_974396.1 3268 0.0e+00 PREDICTED: integrator complex subunit 6 [Tribolium castaneum]>gi|270005607|gb|EFA02055.1| hypothetical protein TcasGA2_TC007684 [Tribolium castaneum] 571553425 XM_395179.4 238 1.11384e-118 PREDICTED: Apis mellifera integrator complex subunit 6-like (LOC411711), transcript variant X2, mRNA K13143 INTS6, DDX26 integrator complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13143 Q9UL03 1794 1.2e-198 Integrator complex subunit 6 OS=Homo sapiens GN=INTS6 PE=1 SV=1 PF15150 Phorbol-12-myristate-13-acetate-induced GO:0006974//GO:0001836//GO:0006915//GO:0006919 cellular response to DNA damage stimulus//release of cytochrome c from mitochondria//apoptotic process//activation of cysteine-type endopeptidase activity involved in apoptotic process -- -- -- -- KOG3768 DEAD box RNA helicase Cluster-8309.5567 BP_3 507.58 5.35 4862 642930553 XP_966739.2 2882 0.0e+00 PREDICTED: uncharacterized protein LOC655137 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55671 BP_3 438.98 5.28 4297 270001539 EEZ97986.1 1949 2.8e-215 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 364 0 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1027 9.4e-110 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.55672 BP_3 9.41 0.97 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55677 BP_3 342.00 3.47 5044 642924398 XP_008194279.1 1399 2.0e-151 PREDICTED: fibril-forming collagen alpha chain-like [Tribolium castaneum]>gi|270007894|gb|EFA04342.1| hypothetical protein TcasGA2_TC014637 [Tribolium castaneum] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 Q91717 573 4.9e-57 Collagen alpha-1(II) chain OS=Xenopus laevis GN=col2a1 PE=2 SV=2 PF00714//PF01410//PF00093//PF12658 Interferon gamma//Fibrillar collagen C-terminal domain//von Willebrand factor type C domain//Telomere capping, CST complex subunit GO:0010833//GO:0007165//GO:0006955 telomere maintenance via telomere lengthening//signal transduction//immune response GO:0005133//GO:0005515//GO:0043047//GO:0005201 interferon-gamma receptor binding//protein binding//single-stranded telomeric DNA binding//extracellular matrix structural constituent GO:0005581//GO:0005576//GO:0070188//GO:0005578 collagen trimer//extracellular region//obsolete Stn1-Ten1 complex//proteinaceous extracellular matrix -- -- Cluster-8309.55680 BP_3 49.68 2.20 1381 861610178 KMQ85078.1 943 4.0e-99 dna-mediated transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12940 Recombination-activation protein 1 (RAG1) GO:0033151 V(D)J recombination GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.55682 BP_3 638.44 10.27 3287 91084581 XP_973970.1 1723 3.4e-189 PREDICTED: signal peptide peptidase-like 3 isoform X1 [Tribolium castaneum]>gi|270008893|gb|EFA05341.1| hypothetical protein TcasGA2_TC015505 [Tribolium castaneum] 27820031 BT003288.1 200 9.85608e-98 Drosophila melanogaster GM06145 full insert cDNA K09598 SPPL3 signal peptide peptidase-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09598 Q9CUS9 1217 6.7e-132 Signal peptide peptidase-like 3 OS=Mus musculus GN=Sppl3 PE=1 SV=3 PF04258 Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.55697 BP_3 89.00 14.19 594 532759730 AGU01545.1 278 2.2e-22 antimicrobial peptide type 2 precursor IIc [Pandalopsis japonica] 820844958 XM_012485111.1 35 8.97723e-07 PREDICTED: Apis florea vegetative cell wall protein gp1-like (LOC105735137), mRNA -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.55700 BP_3 99.22 3.20 1785 91083701 XP_969551.1 798 3.4e-82 PREDICTED: PITH domain-containing protein CG6153 [Tribolium castaneum]>gi|270006812|gb|EFA03260.1| hypothetical protein TcasGA2_TC013194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29L80 614 3.0e-62 PITH domain-containing protein GA19395 OS=Drosophila pseudoobscura pseudoobscura GN=GA19395 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1730 Thioredoxin-like protein Cluster-8309.55701 BP_3 15.00 0.31 2606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55703 BP_3 21.28 0.38 3001 546682082 ERL92068.1 1318 2.9e-142 hypothetical protein D910_09390 [Dendroctonus ponderosae] -- -- -- -- -- K12487 GIT2 G protein-coupled receptor kinase interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12487 Q9JLQ2 789 2.6e-82 ARF GTPase-activating protein GIT2 OS=Mus musculus GN=Git2 PE=1 SV=2 PF02050//PF01166//PF03836//PF00023//PF01412//PF06005//PF13851//PF06156//PF13606 Flagellar FliJ protein//TSC-22/dip/bun family//RasGAP C-terminus//Ankyrin repeat//Putative GTPase activating protein for Arf//Protein of unknown function (DUF904)//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF972)//Ankyrin repeat GO:0043093//GO:0000917//GO:0007264//GO:0006935//GO:0048870//GO:0071973//GO:0006260//GO:0006355 FtsZ-dependent cytokinesis//barrier septum assembly//small GTPase mediated signal transduction//chemotaxis//cell motility//bacterial-type flagellum-dependent cell motility//DNA replication//regulation of transcription, DNA-templated GO:0003774//GO:0005515//GO:0003700//GO:0005096 motor activity//protein binding//transcription factor activity, sequence-specific DNA binding//GTPase activator activity GO:0016020//GO:0005667//GO:0009288//GO:0005737//GO:0031514 membrane//transcription factor complex//bacterial-type flagellum//cytoplasm//motile cilium KOG0818 GTPase-activating proteins of the GIT family Cluster-8309.55710 BP_3 67.90 0.44 7678 805759871 XP_012153123.1 3655 0.0e+00 PREDICTED: uncharacterized protein LOC100877606 isoform X2 [Megachile rotundata] 805759873 XM_012297744.1 247 1.72801e-123 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 3.2e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.55715 BP_3 399.87 10.01 2218 817053828 XP_012264100.1 1826 2.6e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935874 XM_008199986.1 700 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X3, mRNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 D3ZSZ3 1597 3.9e-176 Serine/threonine-protein kinase NLK OS=Rattus norvegicus GN=Nlk PE=3 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.55718 BP_3 143.25 4.40 1861 546678624 ERL89206.1 602 1.9e-59 hypothetical protein D910_06580 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55724 BP_3 101.88 4.17 1469 478256734 ENN76915.1 1757 1.8e-193 hypothetical protein YQE_06562, partial [Dendroctonus ponderosae]>gi|546672598|gb|ERL84399.1| hypothetical protein D910_01832 [Dendroctonus ponderosae] 807037650 XM_004533743.2 52 8.14928e-16 PREDICTED: Ceratitis capitata tyrosine--tRNA ligase, mitochondrial (LOC101458353), mRNA K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q9W107 1386 7.5e-152 Tyrosine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-tyr-m PE=2 SV=1 PF01479//PF04377//PF00579 S4 domain//Arginine-tRNA-protein transferase, C terminus//tRNA synthetases class I (W and Y) GO:0006418//GO:0016598 tRNA aminoacylation for protein translation//protein arginylation GO:0000166//GO:0005524//GO:0003723//GO:0004057//GO:0004812 nucleotide binding//ATP binding//RNA binding//arginyltransferase activity//aminoacyl-tRNA ligase activity -- -- KOG2623 Tyrosyl-tRNA synthetase Cluster-8309.55725 BP_3 3.00 0.61 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55727 BP_3 580.33 10.39 2984 642916185 XP_008190921.1 1780 7.7e-196 PREDICTED: guanine nucleotide-binding protein-like 1 isoform X1 [Tribolium castaneum]>gi|642916187|ref|XP_008190922.1| PREDICTED: guanine nucleotide-binding protein-like 1 isoform X1 [Tribolium castaneum]>gi|270004156|gb|EFA00604.1| hypothetical protein TcasGA2_TC003476 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36916 1157 5.5e-125 Guanine nucleotide-binding protein-like 1 OS=Mus musculus GN=Gnl1 PE=2 SV=4 PF02421//PF04548//PF06858//PF01926//PF03193//PF08477 Ferrous iron transport protein B//AIG1 family//Nucleolar GTP-binding protein 1 (NOG1)//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0015093//GO:0005525 GTPase activity//ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG1424 Predicted GTP-binding protein MMR1 Cluster-8309.55728 BP_3 41.89 0.76 2943 642921918 XP_008192944.1 2013 7.3e-223 PREDICTED: zinc finger MYND domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15326 593 1.4e-59 Zinc finger MYND domain-containing protein 11 OS=Homo sapiens GN=ZMYND11 PE=1 SV=2 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.55729 BP_3 37.92 0.55 3612 642926488 XP_008191976.1 3672 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase kurz [Tribolium castaneum]>gi|270009095|gb|EFA05543.1| hypothetical protein TcasGA2_TC015731 [Tribolium castaneum] -- -- -- -- -- K14780 DHX37, DHR1 ATP-dependent RNA helicase DHX37/DHR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14780 O46072 2796 0.0e+00 Probable ATP-dependent RNA helicase kurz OS=Drosophila melanogaster GN=kz PE=1 SV=1 PF04408//PF00270//PF07652//PF00437//PF01580 Helicase associated domain (HA2)//DEAD/DEAH box helicase//Flavivirus DEAD domain//Type II/IV secretion system protein//FtsK/SpoIIIE family GO:0019079//GO:0006810 viral genome replication//transport GO:0003676//GO:0000166//GO:0003677//GO:0005524//GO:0004386//GO:0008026 nucleic acid binding//nucleotide binding//DNA binding//ATP binding//helicase activity//ATP-dependent helicase activity -- -- KOG0926 DEAH-box RNA helicase Cluster-8309.55730 BP_3 123.30 1.96 3331 642926488 XP_008191976.1 3345 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase kurz [Tribolium castaneum]>gi|270009095|gb|EFA05543.1| hypothetical protein TcasGA2_TC015731 [Tribolium castaneum] -- -- -- -- -- K14780 DHX37, DHR1 ATP-dependent RNA helicase DHX37/DHR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14780 O46072 2655 1.2e-298 Probable ATP-dependent RNA helicase kurz OS=Drosophila melanogaster GN=kz PE=1 SV=1 PF07652//PF00437//PF00270//PF00931//PF02562//PF04408//PF04851 Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase//NB-ARC domain//PhoH-like protein//Helicase associated domain (HA2)//Type III restriction enzyme, res subunit GO:0019079//GO:0006810 viral genome replication//transport GO:0005524//GO:0004386//GO:0003677//GO:0016787//GO:0008026//GO:0043531//GO:0000166//GO:0003676 ATP binding//helicase activity//DNA binding//hydrolase activity//ATP-dependent helicase activity//ADP binding//nucleotide binding//nucleic acid binding -- -- KOG0926 DEAH-box RNA helicase Cluster-8309.55733 BP_3 48.54 0.33 7399 642917330 XP_008199256.1 2195 1.4e-243 PREDICTED: kazrin isoform X4 [Tribolium castaneum] 642917329 XM_008201034.1 314 9.46882e-161 PREDICTED: Tribolium castaneum kazrin (LOC658072), transcript variant X4, mRNA -- -- -- -- Q674X7 591 5.8e-59 Kazrin OS=Homo sapiens GN=KAZN PE=1 SV=2 PF14010//PF00536//PF04923//PF02183//PF07647//PF09482//PF12285 Phosphoenolpyruvate carboxylase//SAM domain (Sterile alpha motif)//Ninjurin//Homeobox associated leucine zipper//SAM domain (Sterile alpha motif)//Bacterial type III secretion apparatus protein (OrgA_MxiK)//Protein of unknown function (DUF3621) GO:0009405//GO:0006099//GO:0006355//GO:0006094//GO:0042246//GO:0019643//GO:0015977//GO:0007155 pathogenesis//tricarboxylic acid cycle//regulation of transcription, DNA-templated//gluconeogenesis//tissue regeneration//reductive tricarboxylic acid cycle//carbon fixation//cell adhesion GO:0008964//GO:0003700//GO:0004252//GO:0043565//GO:0005515//GO:0070008 phosphoenolpyruvate carboxylase activity//transcription factor activity, sequence-specific DNA binding//serine-type endopeptidase activity//sequence-specific DNA binding//protein binding//serine-type exopeptidase activity GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.55734 BP_3 5.13 0.57 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55737 BP_3 24.80 0.90 1616 270016102 EFA12550.1 394 2.2e-35 hypothetical protein TcasGA2_TC001958 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55739 BP_3 114.00 0.80 7126 642919044 XP_008191710.1 2383 2.2e-265 PREDICTED: neurotactin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23654 1359 5.0e-148 Neurotactin OS=Drosophila melanogaster GN=Nrt PE=1 SV=3 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.55740 BP_3 272.03 9.61 1656 328705425 XP_003242798.1 250 1.1e-18 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00096//PF13465//PF00231 BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//ATP synthase GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0003677//GO:0046933//GO:0046872//GO:0046961 DNA binding//proton-transporting ATP synthase activity, rotational mechanism//metal ion binding//proton-transporting ATPase activity, rotational mechanism GO:0045261//GO:0045259 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex -- -- Cluster-8309.55741 BP_3 109.44 5.69 1219 642920583 XP_008192473.1 225 6.4e-16 PREDICTED: uncharacterized protein LOC103312776 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF00231//PF13639//PF12678//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//ATP synthase//Ring finger domain//RING-H2 zinc finger//BED zinc finger GO:0006119//GO:0015986//GO:0015992 oxidative phosphorylation//ATP synthesis coupled proton transport//proton transport GO:0003677//GO:0005515//GO:0008270//GO:0046872//GO:0046961//GO:0046933 DNA binding//protein binding//zinc ion binding//metal ion binding//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.55743 BP_3 88.45 3.06 1687 328705425 XP_003242798.1 250 1.1e-18 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF00231//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//ATP synthase//BED zinc finger GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0003677//GO:0046933//GO:0046961//GO:0046872 DNA binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//metal ion binding GO:0045261//GO:0045259 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex -- -- Cluster-8309.55744 BP_3 135.60 4.59 1715 328705425 XP_003242798.1 250 1.1e-18 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00231//PF13465//PF00096 BED zinc finger//ATP synthase//Zinc-finger double domain//Zinc finger, C2H2 type GO:0015992//GO:0015986//GO:0006119 proton transport//ATP synthesis coupled proton transport//oxidative phosphorylation GO:0046872//GO:0046961//GO:0046933//GO:0003677 metal ion binding//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism//DNA binding GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.55755 BP_3 54.00 4.70 846 591373737 XP_007061563.1 869 9.4e-91 PREDICTED: elongation factor 1-alpha 1 [Chelonia mydas]>gi|465975678|gb|EMP34197.1| Elongation factor 1-alpha 1 [Chelonia mydas] 697073754 XM_009653212.1 595 0 Verticillium dahliae VdLs.17 elongation factor 1-alpha partial mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P41745 866 8.6e-92 Elongation factor 1-alpha OS=Blastobotrys adeninivorans GN=TEF PE=3 SV=1 PF03144 Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.55756 BP_3 14.00 0.46 1754 736288478 XP_010790447.1 333 2.8e-28 PREDICTED: uncharacterized protein LOC104963547 isoform X1 [Notothenia coriiceps]>gi|736288480|ref|XP_010790448.1| PREDICTED: uncharacterized protein LOC104963547 isoform X1 [Notothenia coriiceps] 697069082 XM_009651430.1 1691 0 Verticillium dahliae VdLs.17 FAD binding domain-containing protein partial mRNA -- -- -- -- -- -- -- -- PF01494//PF07992//PF05834//PF01266 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0071949//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oxidoreductase activity -- -- -- -- Cluster-8309.55757 BP_3 9.00 4.18 394 823649307 AKI32824.1 604 2.3e-60 elongation factor 1-alpha, partial [Doratopsylla dasycnema dasycnema] 697073754 XM_009653212.1 373 0 Verticillium dahliae VdLs.17 elongation factor 1-alpha partial mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q01520 653 2.0e-67 Elongation factor 1-alpha OS=Podospora anserina GN=TEF PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.55759 BP_3 11.00 20.74 299 564344879 XP_006235797.1 366 7.0e-33 PREDICTED: elongation factor 1-alpha 2 isoform X2 [Rattus norvegicus] 768311754 CP010982.1 186 4.89255e-91 Verticillium dahliae VdLs.17 chromosome 3, complete sequence K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q09069 368 1.7e-34 Elongation factor 1-alpha OS=Sordaria macrospora GN=TEF PE=3 SV=1 PF01580//PF06431//PF00503 FtsK/SpoIIIE family//Polyomavirus large T antigen C-terminus//G-protein alpha subunit GO:0007186//GO:0006260//GO:0007165 G-protein coupled receptor signaling pathway//DNA replication//signal transduction GO:0000166//GO:0019001//GO:0004871//GO:0003924//GO:0005524//GO:0031683//GO:0003677 nucleotide binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//DNA binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.55761 BP_3 163.85 1.87 4521 91090274 XP_970683.1 4743 0.0e+00 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08333 PIK3R4, VPS15 phosphoinositide-3-kinase, regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08333 Q8VD65 1913 1.8e-212 Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus GN=Pik3r4 PE=1 SV=3 PF07714//PF00400//PF02985//PF00069 Protein tyrosine kinase//WD domain, G-beta repeat//HEAT repeat//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- KOG1240 Protein kinase containing WD40 repeats Cluster-8309.55764 BP_3 29.24 0.46 3324 795111383 XP_011882465.1 175 1.1e-09 PREDICTED: gastrula zinc finger protein xFG20-1-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- P0CG31 142 3.0e-07 Putative zinc finger protein 286B OS=Homo sapiens GN=ZNF286B PE=5 SV=1 PF05191//PF02892//PF00847//PF00096//PF13465 Adenylate kinase, active site lid//BED zinc finger//AP2 domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006355//GO:0046034//GO:0006144 regulation of transcription, DNA-templated//ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872//GO:0003700//GO:0003677 adenylate kinase activity//metal ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.55765 BP_3 655.68 3.86 8474 478261817 ENN80940.1 1262 2.5e-135 hypothetical protein YQE_02645, partial [Dendroctonus ponderosae]>gi|546673708|gb|ERL85267.1| hypothetical protein D910_02688 [Dendroctonus ponderosae] -- -- -- -- -- K05610 UCHL5, UCH37 ubiquitin carboxyl-terminal hydrolase L5 http://www.genome.jp/dbget-bin/www_bget?ko:K05610 Q9XSJ0 1055 1.0e-112 Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Bos taurus GN=UCHL5 PE=2 SV=1 PF00397//PF01404//PF00552//PF02845//PF00325//PF01088 WW domain//Ephrin receptor ligand binding domain//Integrase DNA binding domain//CUE domain//Bacterial regulatory proteins, crp family//Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0016579//GO:0006511//GO:0006355//GO:0048013//GO:0006508 protein deubiquitination//ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated//ephrin receptor signaling pathway//proteolysis GO:0005515//GO:0003677//GO:0004843//GO:0003676 protein binding//DNA binding//ubiquitin-specific protease activity//nucleic acid binding GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.55768 BP_3 17.26 0.93 1191 189239328 XP_973240.2 1344 1.1e-145 PREDICTED: ribosome-releasing factor 2, mitochondrial [Tribolium castaneum] 242013425 XM_002427363.1 110 3.76275e-48 Pediculus humanus corporis elongation factor G 2, putative, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 Q9VCX4 991 3.9e-106 Ribosome-releasing factor 2, mitochondrial OS=Drosophila melanogaster GN=EF-G2 PE=2 SV=3 PF01926//PF03144//PF04548 50S ribosome-binding GTPase//Elongation factor Tu domain 2//AIG1 family -- -- GO:0005525 GTP binding -- -- KOG0465 Mitochondrial elongation factor Cluster-8309.55769 BP_3 7.00 1.02 622 91095249 XP_971558.1 164 3.9e-09 PREDICTED: 60S ribosome subunit biogenesis protein NIP7 homolog [Tribolium castaneum]>gi|270016870|gb|EFA13316.1| hypothetical protein TcasGA2_TC006900 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q503P2 144 3.3e-08 60S ribosome subunit biogenesis protein NIP7 homolog OS=Danio rerio GN=nip7 PE=2 SV=1 -- -- GO:0042255 ribosome assembly GO:0003723 RNA binding GO:0005634 nucleus KOG3492 Ribosome biogenesis protein NIP7 Cluster-8309.5577 BP_3 6.00 0.63 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55778 BP_3 31.75 0.89 2017 91087247 XP_975518.1 943 5.9e-99 PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929756|ref|XP_008195961.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929758|ref|XP_008195962.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929760|ref|XP_008195963.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q6DCX5 212 1.4e-15 Proton-coupled folate transporter OS=Xenopus laevis GN=slc46a1 PE=2 SV=1 PF07690//PF03137//PF00083 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Sugar (and other) transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.55784 BP_3 45.79 0.90 2753 642911484 XP_008199443.1 1333 4.8e-144 PREDICTED: uncharacterized protein LOC662426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15599 151 2.3e-08 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens GN=SLC9A3R2 PE=1 SV=2 PF13639//PF00595//PF14634//PF13180//PF03145 Ring finger domain//PDZ domain (Also known as DHR or GLGF)//zinc-RING finger domain//PDZ domain//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.55785 BP_3 51.53 0.31 8313 478253875 ENN74167.1 1646 7.4e-180 hypothetical protein YQE_09140, partial [Dendroctonus ponderosae] 642911731 XM_008202495.1 40 2.20232e-08 PREDICTED: Tribolium castaneum uncharacterized LOC660279 (LOC660279), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55788 BP_3 4.00 0.64 591 827549018 XP_004927171.2 202 1.4e-13 PREDICTED: uncharacterized protein LOC101744263 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55794 BP_3 50.18 0.49 5236 260822661 XP_002606720.1 635 7.9e-63 hypothetical protein BRAFLDRAFT_82360 [Branchiostoma floridae]>gi|229292064|gb|EEN62730.1| hypothetical protein BRAFLDRAFT_82360 [Branchiostoma floridae] -- -- -- -- -- K15338 GEN1, GEN flap endonuclease GEN http://www.genome.jp/dbget-bin/www_bget?ko:K15338 P17035 599 4.9e-60 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF02892//PF13912//PF00752//PF13465//PF06814//PF00867//PF07776//PF00096 BED zinc finger//C2H2-type zinc finger//XPG N-terminal domain//Zinc-finger double domain//Lung seven transmembrane receptor//XPG I-region//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type GO:0006281 DNA repair GO:0008270//GO:0003677//GO:0004518//GO:0046872 zinc ion binding//DNA binding//nuclease activity//metal ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.55795 BP_3 2.00 0.93 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55798 BP_3 17.00 0.42 2248 646704990 KDR12910.1 288 5.9e-23 hypothetical protein L798_13136 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8T4J9 134 1.7e-06 Pupal cuticle protein 27 OS=Manduca sexta GN=PCP27 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.5580 BP_3 250.37 10.44 1448 524865070 XP_005089367.1 366 3.4e-32 PREDICTED: uncharacterized protein LOC101847229 isoform X1 [Aplysia californica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.55801 BP_3 33.00 0.64 2758 861625712 KMQ88624.1 1020 9.5e-108 hypothetical protein RF55_11861 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02527 rRNA small subunit methyltransferase G GO:0000154//GO:0006396//GO:0006364 rRNA modification//RNA processing//rRNA processing GO:0008649 rRNA methyltransferase activity GO:0005737 cytoplasm -- -- Cluster-8309.55802 BP_3 40.85 0.48 4376 642918102 XP_008194021.1 911 6.6e-95 PREDICTED: Krueppel-like factor 5 isoform X1 [Tribolium castaneum] 642918101 XM_008195799.1 368 0 PREDICTED: Tribolium castaneum Krueppel-like factor 6 (LOC103313193), transcript variant X1, mRNA K09206 KLF5 krueppel-like factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09206 Q5VIY5 216 1.1e-15 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF10232//PF00471//PF15060//PF13465//PF00096 C2H2-type zinc finger//Mediator of RNA polymerase II transcription complex subunit 8//Ribosomal protein L33//Differentiation and proliferation regulator//Zinc-finger double domain//Zinc finger, C2H2 type GO:0007275//GO:0006412//GO:0030154//GO:0006357//GO:0042254 multicellular organismal development//translation//cell differentiation//regulation of transcription from RNA polymerase II promoter//ribosome biogenesis GO:0001104//GO:0003735//GO:0046872 RNA polymerase II transcription cofactor activity//structural constituent of ribosome//metal ion binding GO:0016592//GO:0005840//GO:0005622 mediator complex//ribosome//intracellular -- -- Cluster-8309.55803 BP_3 1.00 1.03 330 642917969 XP_008198964.1 256 4.4e-20 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [Tribolium castaneum] -- -- -- -- -- K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q28007 201 4.3e-15 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Bos taurus GN=DPYD PE=1 SV=1 PF07992 Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1799 Dihydropyrimidine dehydrogenase Cluster-8309.55804 BP_3 5.00 1.01 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55805 BP_3 189.68 2.44 4045 847140834 XP_012821161.1 437 5.6e-40 PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis]>gi|847140836|ref|XP_012821162.1| PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- E9QAG8 409 4.1e-38 Zinc finger protein 431 OS=Mus musculus GN=Znf431 PE=1 SV=1 PF13912//PF17123//PF02892//PF07776//PF16622//PF13465//PF00096 C2H2-type zinc finger//RING-like zinc finger//BED zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0008270//GO:0046872//GO:0005515 DNA binding//zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.55806 BP_3 20.56 0.36 3075 642925855 XP_008190573.1 1334 4.1e-144 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K06171 NCSTN nicastrin http://www.genome.jp/dbget-bin/www_bget?ko:K06171 Q9VC27 803 6.3e-84 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF05450 Nicastrin GO:0016485 protein processing -- -- GO:0016021 integral component of membrane KOG2657 Transmembrane glycoprotein nicastrin Cluster-8309.55809 BP_3 74.85 0.32 11509 642937629 XP_008198876.1 4353 0.0e+00 PREDICTED: tubby-related protein 4 [Tribolium castaneum] 462288762 APGK01055065.1 72 4.9659e-26 Dendroctonus ponderosae Seq01055075, whole genome shotgun sequence -- -- -- -- Q9JIL5 1348 1.5e-146 Tubby-related protein 4 OS=Mus musculus GN=Tulp4 PE=2 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- KOG2503 Tubby superfamily protein TULP4 Cluster-8309.55810 BP_3 404.76 13.34 1754 332374182 AEE62232.1 1026 1.2e-108 unknown [Dendroctonus ponderosae] 805779661 XM_003702443.2 140 1.17738e-64 PREDICTED: Megachile rotundata small nuclear ribonucleoprotein Sm D3 (LOC100875824), mRNA K06127 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase http://www.genome.jp/dbget-bin/www_bget?ko:K06127 Q9VYF8 876 1.2e-92 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Drosophila melanogaster GN=Coq5 PE=2 SV=1 PF00107//PF01209//PF05148//PF01795//PF08241 Zinc-binding dehydrogenase//ubiE/COQ5 methyltransferase family//Hypothetical methyltransferase//MraW methylase family//Methyltransferase domain GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0008168 methyltransferase activity -- -- KOG1540 Ubiquinone biosynthesis methyltransferase COQ5 Cluster-8309.55814 BP_3 81.00 10.60 660 642922950 XP_008200465.1 463 8.8e-44 PREDICTED: 28S ribosomal protein S14, mitochondrial [Tribolium castaneum]>gi|270008302|gb|EFA04750.1| hypothetical protein TcasGA2_TC030556 [Tribolium castaneum] -- -- -- -- -- K02954 RP-S14, MRPS14, rpsN small subunit ribosomal protein S14 http://www.genome.jp/dbget-bin/www_bget?ko:K02954 Q6B860 353 2.1e-32 28S ribosomal protein S14, mitochondrial OS=Bos taurus GN=MRPS14 PE=1 SV=1 PF00253 Ribosomal protein S14p/S29e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1741 Mitochondrial/chloroplast ribosomal protein S14/S29 Cluster-8309.55815 BP_3 2.00 0.82 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55817 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55819 BP_3 333.96 31.61 801 157112715 XP_001657613.1 423 4.6e-39 AAEL006251-PA [Aedes aegypti]>gi|122117820|sp|Q176V0.1|UFM1_AEDAE RecName: Full=Ubiquitin-fold modifier 1; Flags: Precursor [Aedes aegypti]>gi|108877961|gb|EAT42186.1| AAEL006251-PA [Aedes aegypti] -- -- -- -- -- K12162 UFM1 ubiquitin-fold modifier 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12162 Q176V0 423 1.9e-40 Ubiquitin-fold modifier 1 OS=Aedes aegypti GN=AAEL006251 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3483 Uncharacterized conserved protein Cluster-8309.55821 BP_3 43.33 0.91 2597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03603//PF13931//PF01769//PF02950 DNA polymerase III psi subunit//Kinesin-associated microtubule-binding//Divalent cation transporter//Conotoxin GO:0006810//GO:0009405//GO:0006260//GO:0006812 transport//pathogenesis//DNA replication//cation transport GO:0003887//GO:0008200//GO:0008017//GO:0008408//GO:0008324 DNA-directed DNA polymerase activity//ion channel inhibitor activity//microtubule binding//3'-5' exonuclease activity//cation transmembrane transporter activity GO:0045298//GO:0042575//GO:0005576 tubulin complex//DNA polymerase complex//extracellular region -- -- Cluster-8309.55828 BP_3 72.84 7.03 791 270002738 EEZ99185.1 467 3.6e-44 serine protease H6 [Tribolium castaneum] 462358611 APGK01030035.1 93 6.95069e-39 Dendroctonus ponderosae Seq01030045, whole genome shotgun sequence -- -- -- -- E1BLP6 266 3.0e-22 AT-rich interactive domain-containing protein 5B OS=Bos taurus GN=ARID5B PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55830 BP_3 96.73 1.57 3261 642928537 XP_008195365.1 798 6.2e-82 PREDICTED: serine protease easter-like [Tribolium castaneum]>gi|270011008|gb|EFA07456.1| serine protease P95 [Tribolium castaneum] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q7ZWD4 549 1.9e-54 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Danio rerio GN=uap1l1 PE=2 SV=1 PF01704//PF07657//PF00089 UTP--glucose-1-phosphate uridylyltransferase//N terminus of Notch ligand//Trypsin GO:0007219//GO:0008152//GO:0007275//GO:0006508 Notch signaling pathway//metabolic process//multicellular organismal development//proteolysis GO:0070569//GO:0008236//GO:0004252 uridylyltransferase activity//serine-type peptidase activity//serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.55834 BP_3 70.06 1.04 3535 270013030 EFA09478.1 1071 1.5e-113 hypothetical protein TcasGA2_TC010972 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F99 233 9.1e-18 SH3 and cysteine-rich domain-containing protein 3 OS=Xenopus tropicalis GN=stac3 PE=2 SV=1 PF00018//PF14604//PF06703 SH3 domain//Variant SH3 domain//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0005515//GO:0008233 protein binding//peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.55835 BP_3 6.74 0.51 925 642934204 XP_008199651.1 578 5.7e-57 PREDICTED: gem-associated protein 2 [Tribolium castaneum] -- -- -- -- -- K13130 SIP1, GEMIN2 survival of motor neuron protein-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13130 O42260 263 7.9e-22 Gem-associated protein 2 OS=Xenopus laevis GN=gemin2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55837 BP_3 90.28 1.52 3162 91089209 XP_967093.1 2475 2.1e-276 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog [Tribolium castaneum]>gi|270012470|gb|EFA08918.1| hypothetical protein TcasGA2_TC006624 [Tribolium castaneum] -- -- -- -- -- K14439 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14439 Q9VL72 1413 1.2e-154 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog OS=Drosophila melanogaster GN=Etl1 PE=1 SV=1 PF04851//PF00176//PF02845//PF00270 Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//CUE domain//DEAD/DEAH box helicase -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524//GO:0005515 nucleic acid binding//hydrolase activity//DNA binding//ATP binding//protein binding -- -- KOG0389 SNF2 family DNA-dependent ATPase Cluster-8309.55838 BP_3 49.73 0.41 6155 546675155 ERL86391.1 1444 1.4e-156 hypothetical protein D910_03799 [Dendroctonus ponderosae] -- -- -- -- -- K14859 SSF1_2 ribosome biogenesis protein SSF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14859 Q9VDE5 984 1.3e-104 Protein Peter pan OS=Drosophila melanogaster GN=ppan PE=1 SV=1 PF13414//PF14721//PF02086//PF00515//PF13371//PF03602//PF01555//PF14863//PF08241//PF05944//PF13181//PF02384 TPR repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term//D12 class N6 adenine-specific DNA methyltransferase//Tetratricopeptide repeat//Tetratricopeptide repeat//Conserved hypothetical protein 95//DNA methylase//Alkyl sulfatase dimerisation//Methyltransferase domain//Phage small terminase subunit//Tetratricopeptide repeat//N-6 DNA Methylase GO:0006306//GO:0019069//GO:0031167//GO:0008152//GO:0032775 DNA methylation//viral capsid assembly//rRNA methylation//metabolic process//DNA methylation on adenine GO:0009007//GO:0008170//GO:0008168//GO:0005515//GO:0046983//GO:0003677//GO:0004519 site-specific DNA-methyltransferase (adenine-specific) activity//N-methyltransferase activity//methyltransferase activity//protein binding//protein dimerization activity//DNA binding//endonuclease activity -- -- KOG2963 RNA-binding protein required for 60S ribosomal subunit biogenesis Cluster-8309.55839 BP_3 15.00 0.62 1456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55842 BP_3 2.57 35.32 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55846 BP_3 4.06 0.53 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5585 BP_3 2.00 0.47 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55852 BP_3 6.00 0.80 653 270008606 EFA05054.1 600 1.1e-59 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55854 BP_3 335.20 7.32 2500 642931178 XP_001810533.2 1913 2.4e-211 PREDICTED: general transcription factor 3C polypeptide 3 [Tribolium castaneum]>gi|270011861|gb|EFA08309.1| hypothetical protein TcasGA2_TC005945 [Tribolium castaneum] -- -- -- -- -- K15201 GTP3C3, TFC4 general transcription factor 3C polypeptide 3 (transcription factor C subunit 4) http://www.genome.jp/dbget-bin/www_bget?ko:K15201 Q9Y5Q9 739 1.4e-76 General transcription factor 3C polypeptide 3 OS=Homo sapiens GN=GTF3C3 PE=1 SV=1 PF13414//PF16045//PF13176//PF08631//PF00515//PF13181 TPR repeat//LisH//Tetratricopeptide repeat//Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0051321 meiotic cell cycle GO:0005515 protein binding -- -- KOG2076 RNA polymerase III transcription factor TFIIIC Cluster-8309.55856 BP_3 169.36 1.66 5202 270009045 EFA05493.1 2683 2.6e-300 hypothetical protein TcasGA2_TC015678 [Tribolium castaneum] 194763458 XM_001963814.1 371 0 Drosophila ananassae GF21038 (Dana\GF21038), mRNA -- -- -- -- Q9JJZ8 950 9.7e-101 Cyclic nucleotide-gated cation channel alpha-3 OS=Mus musculus GN=Cnga3 PE=1 SV=2 PF00520//PF03938 Ion transport protein//Outer membrane protein (OmpH-like) GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0051082//GO:0005216 unfolded protein binding//ion channel activity GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.55859 BP_3 79.91 2.23 2022 675379531 KFM72433.1 325 2.7e-27 Zinc finger protein 99, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UK10 284 6.3e-24 Zinc finger protein 225 OS=Homo sapiens GN=ZNF225 PE=2 SV=2 PF07975//PF00096//PF13465//PF07776//PF13912//PF04810 TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Sec23/Sec24 zinc finger GO:0006281//GO:0006886//GO:0006888 DNA repair//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0030127//GO:0005634 COPII vesicle coat//nucleus -- -- Cluster-8309.5586 BP_3 51.00 0.73 3664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55860 BP_3 84.35 0.83 5193 91083351 XP_975052.1 2592 9.3e-290 PREDICTED: gamma-tubulin complex component 3 [Tribolium castaneum]>gi|270007769|gb|EFA04217.1| hypothetical protein TcasGA2_TC014466 [Tribolium castaneum] -- -- -- -- -- K16570 TUBGCP3, GCP3 gamma-tubulin complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16570 P58854 1192 8.4e-129 Gamma-tubulin complex component 3 OS=Mus musculus GN=Tubgcp3 PE=2 SV=2 PF04130 Spc97 / Spc98 family GO:0090063//GO:0000226 positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0005815//GO:0000922//GO:0044430//GO:0015630 microtubule organizing center//spindle pole//cytoskeletal part//microtubule cytoskeleton KOG2000 Gamma-tubulin complex, DGRIP91/SPC98 component Cluster-8309.55865 BP_3 91.81 6.64 958 91083363 XP_975142.1 498 1.1e-47 PREDICTED: diacylglycerol O-acyltransferase 1 [Tribolium castaneum]>gi|270007773|gb|EFA04221.1| hypothetical protein TcasGA2_TC014471 [Tribolium castaneum] -- -- -- -- -- K11155 DGAT1 diacylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11155 Q8MK44 147 2.3e-08 Diacylglycerol O-acyltransferase 1 OS=Bos taurus GN=DGAT1 PE=2 SV=2 -- -- GO:0042967 acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.55871 BP_3 153.63 21.32 639 91084789 XP_972673.1 485 2.4e-46 PREDICTED: 6-pyruvoyl tetrahydrobiopterin synthase [Tribolium castaneum]>gi|270008955|gb|EFA05403.1| hypothetical protein TcasGA2_TC015575 [Tribolium castaneum] -- -- -- -- -- K01737 queD, ptpS, PTS 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01737 P48611 360 3.1e-33 6-pyruvoyl tetrahydrobiopterin synthase OS=Drosophila melanogaster GN=pr PE=1 SV=1 -- -- GO:0046656//GO:0006729 folic acid biosynthetic process//tetrahydrobiopterin biosynthetic process GO:0046872//GO:0003874 metal ion binding//6-pyruvoyltetrahydropterin synthase activity -- -- KOG4105 6-pyruvoyl tetrahydrobiopterin synthase Cluster-8309.55873 BP_3 420.42 10.98 2137 189235172 XP_001811552.1 2109 3.9e-234 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum]>gi|270003118|gb|EEZ99565.1| hypothetical protein TcasGA2_TC001549 [Tribolium castaneum] 749791080 XM_011150425.1 87 4.17648e-35 PREDICTED: Harpegnathos saltator discoidin domain-containing receptor 2-like (LOC105188791), transcript variant X2, mRNA K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 687 1.2e-70 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF02480//PF00228 Alphaherpesvirus glycoprotein E//Bowman-Birk serine protease inhibitor family GO:0007155 cell adhesion GO:0004867 serine-type endopeptidase inhibitor activity GO:0005576//GO:0016020 extracellular region//membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.55874 BP_3 11.01 0.67 1078 478260919 ENN80542.1 403 1.3e-36 hypothetical protein YQE_03036, partial [Dendroctonus ponderosae]>gi|546684164|gb|ERL93869.1| hypothetical protein D910_11155 [Dendroctonus ponderosae] -- -- -- -- -- K11687 ADPRHL2 poly(ADP-ribose) glycohydrolase ARH3 http://www.genome.jp/dbget-bin/www_bget?ko:K11687 Q3SYV9 269 1.8e-22 Poly(ADP-ribose) glycohydrolase ARH3 OS=Bos taurus GN=ADPRHL2 PE=2 SV=1 PF01566 Natural resistance-associated macrophage protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.55877 BP_3 573.10 19.37 1718 546673009 ERL84695.1 199 9.4e-13 hypothetical protein D910_02121 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- C3XVM1 144 9.2e-08 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Branchiostoma floridae GN=BRAFLDRAFT_270748 PE=3 SV=1 PF02686 Glu-tRNAGln amidotransferase C subunit GO:0006450 regulation of translational fidelity -- -- -- -- -- -- Cluster-8309.55881 BP_3 519.00 15.90 1865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55882 BP_3 36.00 0.68 2832 270015858 EFA12306.1 625 6.2e-62 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55885 BP_3 112.98 2.70 2307 91093732 XP_968487.1 1174 1.1e-125 PREDICTED: nuclear hormone receptor HR96 [Tribolium castaneum]>gi|270014223|gb|EFA10671.1| hormone receptor in 96-like protein [Tribolium castaneum] -- -- -- -- -- K14035 NR1IN nuclear receptor subfamily 1 group I http://www.genome.jp/dbget-bin/www_bget?ko:K14035 Q24143 751 5.1e-78 Nuclear hormone receptor HR96 OS=Drosophila melanogaster GN=Hr96 PE=1 SV=1 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401//GO:0007165 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//signal transduction GO:0008270//GO:0043565//GO:0003700//GO:0046872//GO:0003707 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//steroid hormone receptor activity GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3575 FOG: Hormone receptors Cluster-8309.55896 BP_3 84.19 0.60 7094 270006609 EFA03057.1 1367 1.4e-147 hypothetical protein TcasGA2_TC010913 [Tribolium castaneum] 688610729 XM_009296665.1 57 6.65937e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 819 2.0e-85 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF00439//PF00628//PF03832 Bromodomain//PHD-finger//WSK motif GO:0007165//GO:0006605 signal transduction//protein targeting GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.55898 BP_3 34.86 0.57 3265 642921567 XP_008192427.1 2340 9.7e-261 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1235 5.4e-134 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF13374//PF02891//PF00515//PF00637//PF06464//PF13176//PF13181//PF00096 Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat//Region in Clathrin and VPS//DMAP1-binding Domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Zinc finger, C2H2 type GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0008134//GO:0046872//GO:0008270 protein binding//transcription factor binding//metal ion binding//zinc ion binding GO:0005667//GO:0005634//GO:0005622 transcription factor complex//nucleus//intracellular KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.55899 BP_3 188.24 4.28 2413 91088973 XP_966480.1 2893 0.0e+00 PREDICTED: G protein-coupled receptor kinase 1 [Tribolium castaneum]>gi|270011553|gb|EFA08001.1| hypothetical protein TcasGA2_TC005590 [Tribolium castaneum] 158300636 XM_320502.4 498 0 Anopheles gambiae str. PEST AGAP012026-PA (AgaP_AGAP012026) mRNA, partial cds K00910 ADRBK, GRK beta-adrenergic-receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00910 P32865 2605 5.5e-293 G protein-coupled receptor kinase 1 OS=Drosophila melanogaster GN=Gprk1 PE=2 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310//GO:0038032 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//termination of G-protein coupled receptor signaling pathway GO:0005524//GO:0004703//GO:0004672//GO:0016773 ATP binding//G-protein coupled receptor kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0986 G protein-coupled receptor kinase Cluster-8309.559 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55903 BP_3 45.00 4.52 772 -- -- -- -- -- 225697849 FJ827761.1 756 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- PF05746 DALR anticodon binding domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0004814 ATP binding//arginine-tRNA ligase activity -- -- -- -- Cluster-8309.55904 BP_3 6.00 0.40 1014 642911051 XP_008200619.1 151 2.0e-07 PREDICTED: HEAT repeat-containing protein 5B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55905 BP_3 5.00 2.18 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55906 BP_3 470.28 5.62 4328 641783189 XP_008174001.1 762 1.2e-77 PREDICTED: zinc finger protein 850-like, partial [Chrysemys picta bellii] 795495644 XM_011710948.1 39 4.10917e-08 PREDICTED: Macaca nemestrina zinc finger protein 713 (ZNF713), transcript variant X5, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ECI4 734 8.9e-76 Zinc finger protein 470 OS=Homo sapiens GN=ZNF470 PE=2 SV=3 PF13465//PF02178//PF00096//PF08054//PF13912//PF07776 Zinc-finger double domain//AT hook motif//Zinc finger, C2H2 type//Leucine operon leader peptide//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) GO:0009098 leucine biosynthetic process GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.55910 BP_3 23.00 30.37 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55912 BP_3 83.41 1.94 2365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55913 BP_3 16.18 0.37 2384 546683002 ERL92874.1 1134 5.0e-121 hypothetical protein D910_10180 [Dendroctonus ponderosae] -- -- -- -- -- K10649 TRIM9_67 tripartite motif-containing protein 9/67 http://www.genome.jp/dbget-bin/www_bget?ko:K10649 Q91ZY8 709 3.9e-73 E3 ubiquitin-protein ligase TRIM9 OS=Rattus norvegicus GN=Trim9 PE=1 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG4367 Predicted Zn-finger protein Cluster-8309.55915 BP_3 424.71 10.64 2216 91080649 XP_974556.1 3097 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase TRIM9 [Tribolium castaneum]>gi|270005500|gb|EFA01948.1| hypothetical protein TcasGA2_TC007563 [Tribolium castaneum] 645006803 XM_008206707.1 83 7.25138e-33 PREDICTED: Nasonia vitripennis E3 ubiquitin-protein ligase TRIM9 (LOC100121486), transcript variant X3, mRNA K10649 TRIM9_67 tripartite motif-containing protein 9/67 http://www.genome.jp/dbget-bin/www_bget?ko:K10649 Q29RQ5 1656 5.6e-183 E3 ubiquitin-protein ligase TRIM9 OS=Bos taurus GN=TRIM9 PE=2 SV=1 PF00097//PF04048//PF01442//PF00643//PF00622//PF05823//PF00041//PF02601 Zinc finger, C3HC4 type (RING finger)//Sec8 exocyst complex component specific domain//Apolipoprotein A1/A4/E domain//B-box zinc finger//SPRY domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Fibronectin type III domain//Exonuclease VII, large subunit GO:0042157//GO:0006869//GO:0006904//GO:0015031//GO:0006308 lipoprotein metabolic process//lipid transport//vesicle docking involved in exocytosis//protein transport//DNA catabolic process GO:0008289//GO:0005515//GO:0008855//GO:0008270//GO:0046872 lipid binding//protein binding//exodeoxyribonuclease VII activity//zinc ion binding//metal ion binding GO:0000145//GO:0005622//GO:0009318//GO:0005576 exocyst//intracellular//exodeoxyribonuclease VII complex//extracellular region KOG4367 Predicted Zn-finger protein Cluster-8309.55916 BP_3 128.59 3.23 2213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55918 BP_3 37.12 0.53 3657 91091628 XP_970031.1 1242 2.3e-133 PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial [Tribolium castaneum] 780117224 XM_775688.3 40 9.63886e-09 PREDICTED: Strongylocentrotus purpuratus cathepsin L1 (LOC575275), mRNA K00254 DHODH, pyrD dihydroorotate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00254 P32748 1000 1.1e-106 Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Drosophila melanogaster GN=Dhod PE=2 SV=2 PF03060//PF04139//PF15163//PF02144//PF03051//PF01180//PF00112 Nitronate monooxygenase//Rad9//Meiosis-expressed//Repair protein Rad1/Rec1/Rad17//Peptidase C1-like family//Dihydroorotate dehydrogenase//Papain family cysteine protease GO:0006281//GO:0006807//GO:0055114//GO:0000077//GO:0006508 DNA repair//nitrogen compound metabolic process//oxidation-reduction process//DNA damage checkpoint//proteolysis GO:0018580//GO:0004197//GO:0016627//GO:0008234 nitronate monooxygenase activity//cysteine-type endopeptidase activity//oxidoreductase activity, acting on the CH-CH group of donors//cysteine-type peptidase activity GO:0005634//GO:0030896//GO:0005737 nucleus//checkpoint clamp complex//cytoplasm KOG1436 Dihydroorotate dehydrogenase Cluster-8309.55919 BP_3 28.26 0.75 2107 270007518 EFA03966.1 414 1.3e-37 hypothetical protein TcasGA2_TC014111 [Tribolium castaneum] -- -- -- -- -- K11498 CENPE centromeric protein E http://www.genome.jp/dbget-bin/www_bget?ko:K11498 Q54G05 230 1.2e-17 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0003777//GO:0005524//GO:0008017 microtubule motor activity//ATP binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG0242 Kinesin-like protein Cluster-8309.55920 BP_3 12.99 0.39 1887 478262655 ENN81212.1 167 5.3e-09 hypothetical protein YQE_02381, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55921 BP_3 66.36 16.28 488 478262655 ENN81212.1 200 2.0e-13 hypothetical protein YQE_02381, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55922 BP_3 20.66 0.39 2867 -- -- -- -- -- 462386917 APGK01020083.1 73 3.4083e-27 Dendroctonus ponderosae Seq01020093, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55923 BP_3 276.66 6.30 2407 642918676 XP_008191534.1 1111 2.3e-118 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X3 [Tribolium castaneum] 657589840 XM_008301108.1 80 3.66919e-31 PREDICTED: Stegastes partitus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (smarce1), transcript variant X4, mRNA K11651 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11651 O54941 653 1.2e-66 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Mus musculus GN=Smarce1 PE=1 SV=1 PF01496//PF05478 V-type ATPase 116kDa subunit family//Prominin GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0016021//GO:0033179 integral component of membrane//proton-transporting V-type ATPase, V0 domain KOG4715 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin Cluster-8309.55928 BP_3 71.41 2.08 1945 91083955 XP_975011.1 1487 4.7e-162 PREDICTED: prolactin regulatory element-binding protein isoform X1 [Tribolium castaneum]>gi|270007977|gb|EFA04425.1| hypothetical protein TcasGA2_TC014725 [Tribolium castaneum] -- -- -- -- -- K14003 PREB, SEC12 prolactin regulatory element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14003 Q9HCU5 441 3.8e-42 Prolactin regulatory element-binding protein OS=Homo sapiens GN=PREB PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p Cluster-8309.55929 BP_3 38.96 1.19 1875 642922084 XP_008193010.1 389 9.5e-35 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270007256|gb|EFA03704.1| hypothetical protein TcasGA2_TC013809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 295 3.1e-25 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF05083 LST-1 protein GO:0006955//GO:0000902 immune response//cell morphogenesis -- -- GO:0016020 membrane -- -- Cluster-8309.55930 BP_3 36.99 1.05 1983 91079722 XP_969695.1 2570 1.3e-287 PREDICTED: xenotropic and polytropic retrovirus receptor 1 [Tribolium castaneum]>gi|270003331|gb|EEZ99778.1| hypothetical protein TcasGA2_TC002557 [Tribolium castaneum] 827561892 XM_004932993.2 53 3.07796e-16 PREDICTED: Bombyx mori xenotropic and polytropic retrovirus receptor 1 (LOC101739894), mRNA -- -- -- -- Q9Z0U0 1658 2.9e-183 Xenotropic and polytropic retrovirus receptor 1 OS=Mus musculus GN=Xpr1 PE=1 SV=1 PF03124 EXS family -- -- -- -- GO:0016021 integral component of membrane KOG1162 Predicted small molecule transporter Cluster-8309.55931 BP_3 20.15 0.39 2810 642935255 XP_008197934.1 1686 5.7e-185 PREDICTED: coiled-coil domain-containing protein 142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07393//PF04437 Exocyst complex component Sec10//RINT-1 / TIP-1 family GO:0006887//GO:0048278//GO:0048193 exocytosis//vesicle docking//Golgi vesicle transport -- -- GO:0005737//GO:0005783 cytoplasm//endoplasmic reticulum -- -- Cluster-8309.55933 BP_3 9.00 0.86 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55936 BP_3 39.66 1.53 1539 270013655 EFA10103.1 1278 6.4e-138 hypothetical protein TcasGA2_TC012282 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q8BWQ1 616 1.5e-62 UDP-glucuronosyltransferase 2A3 OS=Mus musculus GN=Ugt2a3 PE=1 SV=1 PF04101//PF03839//PF06506//PF00201 Glycosyltransferase family 28 C-terminal domain//Translocation protein Sec62//Propionate catabolism activator//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152//GO:0000160//GO:0015031 metabolic process//phosphorelay signal transduction system//protein transport GO:0016758//GO:0005524//GO:0003677//GO:0008565//GO:0000156 transferase activity, transferring hexosyl groups//ATP binding//DNA binding//protein transporter activity//phosphorelay response regulator activity GO:0016021 integral component of membrane -- -- Cluster-8309.55938 BP_3 22.86 0.69 1884 642933975 XP_972090.2 1364 8.4e-148 PREDICTED: UDP-glucuronosyltransferase 2B10-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P36537 633 2.0e-64 UDP-glucuronosyltransferase 2B10 OS=Homo sapiens GN=UGT2B10 PE=1 SV=1 PF04101//PF00201//PF06506//PF03839 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Propionate catabolism activator//Translocation protein Sec62 GO:0015031//GO:0008152//GO:0000160 protein transport//metabolic process//phosphorelay signal transduction system GO:0008565//GO:0000156//GO:0016758//GO:0005524//GO:0003677 protein transporter activity//phosphorelay response regulator activity//transferase activity, transferring hexosyl groups//ATP binding//DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.55939 BP_3 115.15 1.27 4678 91089905 XP_972496.1 1305 1.4e-140 PREDICTED: UDP-glucuronosyltransferase [Tribolium castaneum]>gi|270013659|gb|EFA10107.1| hypothetical protein TcasGA2_TC012286 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36513 593 2.2e-59 UDP-glucuronosyltransferase 2B14 OS=Oryctolagus cuniculus GN=UGT2B14 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758//GO:0016740 transferase activity, transferring hexosyl groups//transferase activity -- -- -- -- Cluster-8309.55940 BP_3 99.23 3.54 1644 642933975 XP_972090.2 1181 1.2e-126 PREDICTED: UDP-glucuronosyltransferase 2B10-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWQ1 523 9.9e-52 UDP-glucuronosyltransferase 2A3 OS=Mus musculus GN=Ugt2a3 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.55941 BP_3 89.57 2.38 2109 642933977 XP_008197588.1 1322 6.9e-143 PREDICTED: UDP-glucuronosyltransferase 2C1-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O02663 625 1.9e-63 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.55942 BP_3 74.42 1.09 3592 91080681 XP_975202.1 1354 2.3e-146 PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|642919555|ref|XP_008191921.1| PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|270005851|gb|EFA02299.1| hypothetical protein TcasGA2_TC007964 [Tribolium castaneum] 665800505 XM_008549999.1 212 2.30084e-104 PREDICTED: Microplitis demolitor CCR4-NOT transcription complex subunit 7 (LOC103571729), transcript variant X3, mRNA K12581 CNOT7_8, CAF1, POP2 CCR4-NOT transcription complex subunit 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12581 Q9UIV1 1046 4.9e-112 CCR4-NOT transcription complex subunit 7 OS=Homo sapiens GN=CNOT7 PE=1 SV=3 PF13482//PF04857 RNase_H superfamily//CAF1 family ribonuclease -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG0304 mRNA deadenylase subunit Cluster-8309.55943 BP_3 5.00 0.46 811 762142877 XP_011454669.1 168 1.7e-09 PREDICTED: lysosomal alpha-mannosidase-like isoform X1 [Crassostrea gigas] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 O00754 160 6.1e-10 Lysosomal alpha-mannosidase OS=Homo sapiens GN=MAN2B1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.55944 BP_3 108.02 0.95 5779 642920242 XP_008192264.1 5524 0.0e+00 PREDICTED: uncharacterized protein CG43867 isoform X2 [Tribolium castaneum] 194768448 XM_001966288.1 67 1.49664e-23 Drosophila ananassae GF22056 (Dana\GF22056), mRNA -- -- -- -- Q9W5D0 2394 3.9e-268 Uncharacterized protein CG43867 OS=Drosophila melanogaster GN=CG43867 PE=1 SV=4 PF05864//PF00784 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//MyTH4 domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005856//GO:0005730 cytoskeleton//nucleolus KOG0248 Cytoplasmic protein Max-1, contains PH, MyTH4 and FERM domains Cluster-8309.55948 BP_3 262.41 2.34 5689 390362249 XP_001190749.2 822 1.8e-84 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 683 9.6e-70 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55949 BP_3 37.38 0.32 6004 390362249 XP_001190749.2 822 1.9e-84 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 683 1.0e-69 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55953 BP_3 59.49 1.52 2175 91075962 XP_969092.1 1390 9.3e-151 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1160 1.8e-125 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF00270//PF09177//PF04851//PF07517 DEAD/DEAH box helicase//Syntaxin 6, N-terminal//Type III restriction enzyme, res subunit//SecA DEAD-like domain GO:0017038//GO:0048193 protein import//Golgi vesicle transport GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.55954 BP_3 244.73 3.69 3487 642928840 XP_008195584.1 1808 5.1e-199 PREDICTED: dystrophin, isoform E-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7YU29 530 3.3e-52 Dystrophin, isoform E OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF00569//PF00397 Zinc finger, ZZ type//WW domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.55956 BP_3 229.34 6.40 2019 332376975 AEE63627.1 1501 1.2e-163 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 141 3.7782e-65 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1367 1.7e-149 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF04545//PF02984//PF00382//PF01857 Sigma-70, region 4//Cyclin, C-terminal domain//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain GO:0051726//GO:0006352//GO:0006355 regulation of cell cycle//DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003677//GO:0017025//GO:0003700//GO:0016987 DNA binding//TBP-class protein binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1597 Transcription initiation factor TFIIB Cluster-8309.55958 BP_3 37.00 0.73 2725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55959 BP_3 23.00 1.12 1284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55962 BP_3 18.88 0.78 1459 270014160 EFA10608.1 859 2.3e-89 hypothetical protein TcasGA2_TC012869 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KRI2 182 3.1e-12 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF16622//PF00651//PF13912//PF02892//PF13465//PF00096 zinc-finger C2H2-type//BTB/POZ domain//C2H2-type zinc finger//BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.55963 BP_3 27.15 2.37 845 675389799 KFM82696.1 885 1.3e-92 Myosin light chain kinase, smooth muscle, partial [Stegodyphus mimosarum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q15746 729 6.6e-76 Myosin light chain kinase, smooth muscle OS=Homo sapiens GN=MYLK PE=1 SV=4 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.55964 BP_3 7.91 0.59 937 642915738 XP_008190784.1 419 1.6e-38 PREDICTED: kalirin isoform X3 [Tribolium castaneum] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 239 4.8e-19 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55965 BP_3 74.03 1.59 2530 91093353 XP_969001.1 1170 3.5e-125 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] -- -- -- -- -- K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 A0JPQ8 579 4.9e-58 Alkylglycerol monooxygenase OS=Rattus norvegicus GN=Agmo PE=2 SV=1 PF16954//PF05699 Haem-transporter, endosomal/lysosomal, haem-responsive gene//hAT family C-terminal dimerisation region GO:0055114//GO:0006633//GO:0015886 oxidation-reduction process//fatty acid biosynthetic process//heme transport GO:0005506//GO:0015232//GO:0046983//GO:0016491 iron ion binding//heme transporter activity//protein dimerization activity//oxidoreductase activity GO:0016021 integral component of membrane -- -- Cluster-8309.55967 BP_3 64.11 2.30 1636 91093353 XP_969001.1 676 4.4e-68 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] 642938346 XM_963908.3 55 1.95556e-17 PREDICTED: Tribolium castaneum alkylglycerol monooxygenase (LOC657448), mRNA K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 Q5M8F9 395 6.9e-37 Alkylglycerol monooxygenase OS=Xenopus tropicalis GN=agmo PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0055114//GO:0044710//GO:0006633 oxidation-reduction process//single-organism metabolic process//fatty acid biosynthetic process GO:0005506//GO:0016491 iron ion binding//oxidoreductase activity GO:0016020 membrane -- -- Cluster-8309.55970 BP_3 48.97 1.06 2515 91093353 XP_969001.1 1170 3.5e-125 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] -- -- -- -- -- K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 A0JPQ8 579 4.9e-58 Alkylglycerol monooxygenase OS=Rattus norvegicus GN=Agmo PE=2 SV=1 PF16954//PF05699 Haem-transporter, endosomal/lysosomal, haem-responsive gene//hAT family C-terminal dimerisation region GO:0055114//GO:0015886//GO:0006633 oxidation-reduction process//heme transport//fatty acid biosynthetic process GO:0005506//GO:0016491//GO:0046983//GO:0015232 iron ion binding//oxidoreductase activity//protein dimerization activity//heme transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.55971 BP_3 31.01 0.81 2129 91093353 XP_969001.1 681 1.5e-68 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] 642938346 XM_963908.3 55 2.55774e-17 PREDICTED: Tribolium castaneum alkylglycerol monooxygenase (LOC657448), mRNA K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 Q5M8F9 399 3.1e-37 Alkylglycerol monooxygenase OS=Xenopus tropicalis GN=agmo PE=2 SV=1 PF04116//PF00752 Fatty acid hydroxylase superfamily//XPG N-terminal domain GO:0006281//GO:0006633//GO:0044710//GO:0055114 DNA repair//fatty acid biosynthetic process//single-organism metabolic process//oxidation-reduction process GO:0016491//GO:0004518//GO:0005506 oxidoreductase activity//nuclease activity//iron ion binding GO:0016020 membrane -- -- Cluster-8309.55974 BP_3 458.94 29.52 1041 270011245 EFA07693.1 507 1.1e-48 hypothetical protein TcasGA2_TC030782, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X3B2 187 5.7e-13 Adipocyte plasma membrane-associated protein OS=Salmo salar GN=apmap PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG1520 Predicted alkaloid synthase/Surface mucin Hemomucin Cluster-8309.55976 BP_3 115.07 4.92 1419 642919000 XP_974493.2 708 7.4e-72 PREDICTED: 1,5-anhydro-D-fructose reductase [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P80276 402 9.2e-38 Aldose reductase OS=Sus scrofa GN=AKR1B1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.55980 BP_3 31.26 15.81 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55981 BP_3 132.00 6.74 1235 332374090 AEE62186.1 1080 4.7e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10842 MNAT1 CDK-activating kinase assembly factor MAT1 http://www.genome.jp/dbget-bin/www_bget?ko:K10842 P51950 738 8.8e-77 CDK-activating kinase assembly factor MAT1 OS=Marthasterias glacialis PE=1 SV=1 PF06391//PF13639//PF01496//PF17121//PF00097//PF14634//PF03854 CDK-activating kinase assembly factor MAT1//Ring finger domain//V-type ATPase 116kDa subunit family//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//P-11 zinc finger GO:0015992//GO:0007049//GO:0015991 proton transport//cell cycle//ATP hydrolysis coupled proton transport GO:0046872//GO:0008270//GO:0015078//GO:0005515//GO:0003723 metal ion binding//zinc ion binding//hydrogen ion transmembrane transporter activity//protein binding//RNA binding GO:0033179//GO:0005634 proton-transporting V-type ATPase, V0 domain//nucleus KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor Cluster-8309.55982 BP_3 31.68 0.64 2688 675368093 KFM60995.1 143 4.6e-06 hypothetical protein X975_04887, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55983 BP_3 303.67 3.19 4882 642930391 XP_008196378.1 2389 3.0e-266 PREDICTED: uncharacterized protein LOC662968 isoform X1 [Tribolium castaneum]>gi|270010964|gb|EFA07412.1| serine protease P83 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 478 4.9e-46 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.55986 BP_3 10090.00 82.63 6177 91080811 XP_970116.1 1778 2.7e-195 PREDICTED: ufm1-specific protease 2 [Tribolium castaneum]>gi|270005426|gb|EFA01874.1| hypothetical protein TcasGA2_TC007479 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M1D1 1045 1.1e-111 Probable Ufm1-specific protease 2 OS=Drosophila pseudoobscura pseudoobscura GN=UFSP2 PE=3 SV=1 PF03847//PF00125//PF00089//PF02285 Transcription initiation factor TFIID subunit A//Core histone H2A/H2B/H3/H4//Trypsin//Cytochrome oxidase c subunit VIII GO:0006508//GO:0006352//GO:0015992//GO:0006123 proteolysis//DNA-templated transcription, initiation//proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004252//GO:0004129//GO:0003677 serine-type endopeptidase activity//cytochrome-c oxidase activity//DNA binding GO:0005669//GO:0045277 transcription factor TFIID complex//respiratory chain complex IV KOG2433 Uncharacterized conserved protein Cluster-8309.55988 BP_3 5.00 0.63 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55989 BP_3 17.49 0.38 2489 642929013 XP_008195655.1 1308 3.4e-141 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Tribolium castaneum] 759111195 XM_011357078.1 51 5.01582e-15 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K06125 COQ2 4-hydroxybenzoate polyprenyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06125 Q16QL3 1096 5.4e-118 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Aedes aegypti GN=coq2 PE=3 SV=1 PF03419//PF01040//PF02366 Sporulation factor SpoIIGA//UbiA prenyltransferase family//Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0030436//GO:0006508//GO:0006493 asexual sporulation//proteolysis//protein O-linked glycosylation GO:0000030//GO:0004659//GO:0004190 mannosyltransferase activity//prenyltransferase activity//aspartic-type endopeptidase activity GO:0016020//GO:0016021//GO:0000136 membrane//integral component of membrane//alpha-1,6-mannosyltransferase complex KOG1381 Para-hydroxybenzoate-polyprenyl transferase Cluster-8309.55990 BP_3 538.00 17.47 1776 91085075 XP_967088.1 1602 2.0e-175 PREDICTED: lethal(2)neighbour of tid protein [Tribolium castaneum]>gi|270009042|gb|EFA05490.1| hypothetical protein TcasGA2_TC015675 [Tribolium castaneum] -- -- -- -- -- K03845 ALG3 alpha-1,3-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03845 Q27333 1152 1.2e-124 Lethal(2)neighbour of tid protein OS=Drosophila melanogaster GN=l(2)not PE=1 SV=1 PF05208//PF15202 ALG3 protein//Adipogenin GO:0045444 fat cell differentiation GO:0016758 transferase activity, transferring hexosyl groups GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG2762 Mannosyltransferase Cluster-8309.55991 BP_3 221.51 6.96 1826 91094277 XP_970700.1 1463 2.7e-159 PREDICTED: arfaptin-2 [Tribolium castaneum]>gi|270014395|gb|EFA10843.1| hypothetical protein TcasGA2_TC001620 [Tribolium castaneum] 807015662 XM_004517862.2 67 4.66887e-24 PREDICTED: Ceratitis capitata arfaptin-2 (LOC101461303), transcript variant X3, mRNA -- -- -- -- P53365 853 6.0e-90 Arfaptin-2 OS=Homo sapiens GN=ARFIP2 PE=1 SV=1 PF06456//PF03114//PF05823 Arfaptin-like domain//BAR domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1) -- -- GO:0008289//GO:0019904//GO:0005515 lipid binding//protein domain specific binding//protein binding GO:0005737 cytoplasm KOG3651 Protein kinase C, alpha binding protein Cluster-8309.55993 BP_3 142.34 1.77 4173 270003038 EEZ99485.1 772 8.2e-79 hypothetical protein TcasGA2_TC000060 [Tribolium castaneum] -- -- -- -- -- K00791 miaA, TRIT1 tRNA dimethylallyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00791 Q9H3H1 545 7.1e-54 tRNA dimethylallyltransferase, mitochondrial OS=Homo sapiens GN=TRIT1 PE=1 SV=1 PF00931//PF00910//PF01715//PF01637//PF04851//PF06414//PF00096//PF07728//PF01745//PF07475 NB-ARC domain//RNA helicase//IPP transferase//Archaeal ATPase//Type III restriction enzyme, res subunit//Zeta toxin//Zinc finger, C2H2 type//AAA domain (dynein-related subfamily)//Isopentenyl transferase//HPr Serine kinase C-terminal domain GO:0016310//GO:0006694//GO:0008033//GO:0009058//GO:0016114//GO:0006109//GO:0000160 phosphorylation//steroid biosynthetic process//tRNA processing//biosynthetic process//terpenoid biosynthetic process//regulation of carbohydrate metabolic process//phosphorelay signal transduction system GO:0004672//GO:0003724//GO:0046872//GO:0043531//GO:0003723//GO:0003677//GO:0004161//GO:0016301//GO:0016887//GO:0005524//GO:0000155//GO:0016787 protein kinase activity//RNA helicase activity//metal ion binding//ADP binding//RNA binding//DNA binding//dimethylallyltranstransferase activity//kinase activity//ATPase activity//ATP binding//phosphorelay sensor kinase activity//hydrolase activity GO:0009365 protein histidine kinase complex KOG1384 tRNA delta(2)-isopentenylpyrophosphate transferase Cluster-8309.55994 BP_3 1.00 0.76 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56 BP_3 10.00 0.33 1766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09204 Bacterial self-protective colicin-like immunity GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.560 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56000 BP_3 49.66 2.02 1474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14978 Mitochondrial ribosome protein 63 -- -- -- -- GO:0005761 mitochondrial ribosome -- -- Cluster-8309.56001 BP_3 6.00 1.79 453 759058480 XP_011338475.1 263 9.3e-21 PREDICTED: uncharacterized protein LOC105280011 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08220//PF00292 DeoR-like helix-turn-helix domain//'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular -- -- Cluster-8309.56002 BP_3 6.00 0.59 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56003 BP_3 813.12 5.87 6971 478250833 ENN71323.1 1201 2.5e-128 hypothetical protein YQE_11983, partial [Dendroctonus ponderosae]>gi|478259213|gb|ENN79116.1| hypothetical protein YQE_04427, partial [Dendroctonus ponderosae] 642918718 XM_008193332.1 144 2.83637e-66 PREDICTED: Tribolium castaneum zinc finger protein jing homolog (LOC658276), transcript variant X2, mRNA K17452 AEBP2 zinc finger protein AEBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K17452 Q17PR1 641 8.8e-65 Zinc finger protein jing homolog OS=Aedes aegypti GN=AAEL000263 PE=3 SV=1 PF00096//PF13465//PF16622//PF05399 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//Ectropic viral integration site 2A protein (EVI2A) -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.56004 BP_3 39.05 0.42 4825 270014473 EFA10921.1 1390 2.1e-150 hypothetical protein TcasGA2_TC001747 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 1092 3.1e-117 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3578 Uncharacterized conserved protein Cluster-8309.56005 BP_3 25.04 0.35 3753 270014473 EFA10921.1 1384 8.0e-150 hypothetical protein TcasGA2_TC001747 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 1158 5.3e-125 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3578 Uncharacterized conserved protein Cluster-8309.56006 BP_3 12.30 0.36 1925 270014473 EFA10921.1 360 2.3e-31 hypothetical protein TcasGA2_TC001747 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 167 2.2e-10 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56010 BP_3 12.00 1.14 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56014 BP_3 9.34 0.34 1600 642913237 XP_008201451.1 548 3.0e-53 PREDICTED: zinc finger protein 830 [Tribolium castaneum] 828206332 XM_012701468.1 44 2.49035e-11 PREDICTED: Hydra vulgaris zinc finger protein 830-like (LOC100205964), mRNA K13104 ZNF830, CCDC16 zinc finger protein 830 http://www.genome.jp/dbget-bin/www_bget?ko:K13104 Q6DJ13 210 1.9e-15 Zinc finger protein 830 OS=Xenopus tropicalis GN=znf830 PE=2 SV=1 PF16525 Haemophore, haem-binding -- -- GO:0020037 heme binding -- -- KOG3032 Uncharacterized conserved protein Cluster-8309.56017 BP_3 122.84 2.02 3216 642920773 XP_008192554.1 2567 4.6e-287 PREDICTED: LOW QUALITY PROTEIN: spondin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 895 1.4e-94 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.5602 BP_3 3.00 0.32 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56024 BP_3 355.54 2.70 6632 478256920 ENN77089.1 1981 8.4e-219 hypothetical protein YQE_06424, partial [Dendroctonus ponderosae] -- -- -- -- -- K09257 NFKBIL2 NF-kappa-B inhibitor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09257 Q9VSA4 748 3.3e-77 Tonsoku-like protein OS=Drosophila melanogaster GN=CG7457 PE=1 SV=1 PF13606//PF13181//PF13174//PF13374//PF00515//PF02827//PF00023//PF13176//PF13414 Ankyrin repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Ankyrin repeat//Tetratricopeptide repeat//TPR repeat GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG4177 Ankyrin Cluster-8309.56026 BP_3 779.80 9.46 4266 478252382 ENN72808.1 713 5.8e-72 hypothetical protein YQE_10612, partial [Dendroctonus ponderosae]>gi|546680716|gb|ERL90942.1| hypothetical protein D910_08284 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P0C6 362 1.2e-32 Lipoma HMGIC fusion partner-like 2 protein OS=Danio rerio GN=lhfpl2 PE=2 SV=1 PF03161//PF13903 LAGLIDADG DNA endonuclease family//PMP-22/EMP/MP20/Claudin tight junction -- -- GO:0004519 endonuclease activity GO:0016021 integral component of membrane KOG4450 Uncharacterized conserved protein Cluster-8309.56027 BP_3 49.70 0.87 3031 642925139 XP_001813550.2 533 3.1e-51 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42282 287 4.3e-24 Protein tramtrack, alpha isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=3 PF00096//PF02892//PF00651 Zinc finger, C2H2 type//BED zinc finger//BTB/POZ domain -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.56028 BP_3 15.49 0.64 1455 642925139 XP_001813550.2 274 1.6e-21 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56029 BP_3 18.00 0.94 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56030 BP_3 25.21 0.45 2970 270009970 EFA06418.1 952 7.8e-100 hypothetical protein TcasGA2_TC009297 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56031 BP_3 36.94 5.10 641 270012816 EFA09264.1 343 7.0e-30 matrix metalloproteinase 2 [Tribolium castaneum] -- -- -- -- -- K07993 MMP11 matrix metalloproteinase-11 (stromelysin 3) http://www.genome.jp/dbget-bin/www_bget?ko:K07993 Q02853 217 1.2e-16 Stromelysin-3 OS=Mus musculus GN=Mmp11 PE=1 SV=2 PF04726 Microvirus J protein -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.56034 BP_3 7.00 0.97 641 478263091 ENN81487.1 141 1.9e-06 hypothetical protein YQE_02109, partial [Dendroctonus ponderosae]>gi|546685975|gb|ERL95386.1| hypothetical protein D910_12650 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56035 BP_3 18.00 1.23 998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56036 BP_3 4.08 0.72 566 546673906 ERL85422.1 332 1.2e-28 hypothetical protein D910_02842 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05619 136 2.6e-07 Leukocyte elastase inhibitor OS=Equus caballus GN=SERPINB1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56037 BP_3 26.38 0.42 3300 546676105 ERL87172.1 1376 6.0e-149 hypothetical protein D910_04572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7K175 535 8.1e-53 Small RNA 2'-O-methyltransferase OS=Drosophila melanogaster GN=Hen1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1045 Uncharacterized conserved protein HEN1/CORYMBOSA2 Cluster-8309.56040 BP_3 36.31 5.07 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03490 Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.56047 BP_3 72.98 1.19 3237 478251865 ENN72304.1 1079 1.6e-114 hypothetical protein YQE_11047, partial [Dendroctonus ponderosae] 645007963 XM_008205563.1 179 4.5794e-86 PREDICTED: Nasonia vitripennis SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (LOC100118240), transcript variant X4, mRNA K11648 SMARCB1, SNF5, INI1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11648 Q6DFM1 881 6.0e-93 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xenopus tropicalis GN=smarcb1 PE=2 SV=1 PF04855//PF08039 SNF5 / SMARCB1 / INI1//Mitochondrial proteolipid GO:0006338 chromatin remodeling -- -- GO:0000228//GO:0005739 nuclear chromosome//mitochondrion KOG1649 SWI-SNF chromatin remodeling complex, Snf5 subunit Cluster-8309.56049 BP_3 27.60 2.50 824 817061840 XP_012252542.1 492 4.8e-47 PREDICTED: single-stranded DNA-binding protein 3 isoform X2 [Athalia rosae] 632963550 XM_007899757.1 102 7.20256e-44 PREDICTED: Callorhinchus milii single-stranded DNA binding protein 2 (ssbp2), transcript variant X2, mRNA -- -- -- -- Q9D032 412 3.7e-39 Single-stranded DNA-binding protein 3 OS=Mus musculus GN=Ssbp3 PE=1 SV=2 PF08513 LisH -- -- GO:0005515 protein binding -- -- KOG4594 Sequence-specific single-stranded-DNA-binding protein Cluster-8309.5605 BP_3 86.54 3.30 1557 642936948 XP_008198624.1 1496 3.4e-163 PREDICTED: transmembrane protein 39A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NV64 686 1.2e-70 Transmembrane protein 39A OS=Homo sapiens GN=TMEM39A PE=2 SV=1 PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- KOG3828 Uncharacterized conserved protein Cluster-8309.56050 BP_3 206.71 11.02 1196 642913023 XP_008201355.1 1064 3.3e-113 PREDICTED: vacuolar protein sorting-associated protein 72 homolog [Tribolium castaneum] 815809469 XM_012370186.1 67 3.02655e-24 PREDICTED: Linepithema humile vacuolar protein sorting-associated protein 72 homolog (LOC105674081), mRNA K11664 VPS72, TCFL1, YL1 vacuolar protein sorting-associated protein 72 http://www.genome.jp/dbget-bin/www_bget?ko:K11664 Q9VKM6 615 1.6e-62 Vacuolar protein sorting-associated protein 72 homolog OS=Drosophila melanogaster GN=YL-1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2897 DNA-binding protein YL1 and related proteins Cluster-8309.56055 BP_3 75.00 2.89 1541 642936495 XP_008198460.1 253 4.6e-19 PREDICTED: protein tantalus isoform X2 [Tribolium castaneum]>gi|642936497|ref|XP_008198461.1| PREDICTED: protein tantalus isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56057 BP_3 3.00 0.70 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56059 BP_3 6.00 0.36 1097 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56060 BP_3 28.43 0.66 2370 91084077 XP_968062.1 675 8.3e-68 PREDICTED: protein odr-4 homolog [Tribolium castaneum]>gi|270008008|gb|EFA04456.1| hypothetical protein TcasGA2_TC014760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWX8 277 4.8e-23 Protein odr-4 homolog OS=Homo sapiens GN=ODR4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56063 BP_3 5.80 3.83 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00811 Ependymin GO:0007160 cell-matrix adhesion GO:0005509 calcium ion binding GO:0005576 extracellular region -- -- Cluster-8309.56067 BP_3 1.12 0.40 427 642911061 XP_008200558.1 364 1.7e-32 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56068 BP_3 2.00 1.93 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56069 BP_3 131.08 7.66 1116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11429//PF08702 Colicin D//Fibrinogen alpha/beta chain family GO:0051252//GO:0030168//GO:0051258//GO:0007165 regulation of RNA metabolic process//platelet activation//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0004540 receptor binding//protein binding, bridging//ribonuclease activity GO:0005577 fibrinogen complex -- -- Cluster-8309.56070 BP_3 70.42 0.92 3997 861633222 KMQ90883.1 149 1.4e-06 hypothetical protein RF55_9309 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56073 BP_3 111.81 1.49 3917 861633222 KMQ90883.1 149 1.3e-06 hypothetical protein RF55_9309 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56081 BP_3 35.00 0.31 5714 532099958 XP_005335610.1 341 1.1e-28 PREDICTED: zinc finger protein 878-like [Ictidomys tridecemlineatus] 642938230 XM_964647.2 40 1.51145e-08 PREDICTED: Tribolium castaneum scratch 2 (LOC658241), mRNA K09219 SCRT scratch http://www.genome.jp/dbget-bin/www_bget?ko:K09219 Q9P2J8 328 1.4e-28 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF00096//PF01155//PF05495//PF02892//PF13912//PF16622//PF05191//PF13465//PF07975 Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//CHY zinc finger//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc-finger double domain//TFIIH C1-like domain GO:0006144//GO:0046034//GO:0006281//GO:0006464 purine nucleobase metabolic process//ATP metabolic process//DNA repair//cellular protein modification process GO:0004017//GO:0046872//GO:0008270//GO:0016151//GO:0003677 adenylate kinase activity//metal ion binding//zinc ion binding//nickel cation binding//DNA binding -- -- -- -- Cluster-8309.56084 BP_3 11.10 0.50 1366 861626561 KMQ88832.1 1031 2.5e-109 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF03184 helix-turn-helix, Psq domain//DDE superfamily endonuclease -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.56086 BP_3 302.00 12.15 1490 91081125 XP_975535.1 1034 1.2e-109 PREDICTED: protein YIPF6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28CH8 675 2.1e-69 Protein YIPF6 OS=Xenopus tropicalis GN=yipf6 PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG2946 Uncharacterized conserved protein Cluster-8309.56089 BP_3 9.27 0.31 1749 91080251 XP_973223.1 235 6.4e-17 PREDICTED: 4-nitrophenylphosphatase [Tribolium castaneum]>gi|270005691|gb|EFA02139.1| hypothetical protein TcasGA2_TC007789 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 154 6.5e-09 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 -- -- -- -- -- -- -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.56090 BP_3 6.80 0.69 770 91088443 XP_968621.1 251 3.9e-19 PREDICTED: coiled-coil domain-containing protein 47 [Tribolium castaneum]>gi|270011745|gb|EFA08193.1| hypothetical protein TcasGA2_TC005820 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66I12 158 9.8e-10 Coiled-coil domain-containing protein 47 OS=Danio rerio GN=ccdc47 PE=2 SV=1 PF06459//PF12326 Ryanodine Receptor TM 4-6//N-glycosylation protein GO:0006816//GO:0034599//GO:0006874 calcium ion transport//cellular response to oxidative stress//cellular calcium ion homeostasis GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0005789//GO:0016021 intracellular//endoplasmic reticulum membrane//integral component of membrane KOG2357 Uncharacterized conserved protein Cluster-8309.56092 BP_3 2.82 0.57 529 642932705 XP_008196952.1 406 2.9e-37 PREDICTED: HEAT repeat-containing protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AI08 303 1.0e-26 HEAT repeat-containing protein 6 OS=Homo sapiens GN=HEATR6 PE=1 SV=1 PF00514//PF02985 Armadillo/beta-catenin-like repeat//HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56095 BP_3 11.00 0.40 1617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56097 BP_3 55.68 0.65 4438 642940163 XP_972562.2 2091 9.9e-232 PREDICTED: integral membrane protein GPR155 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R9A7 442 6.6e-42 Integral membrane protein GPR155 OS=Pongo abelii GN=GPR155 PE=2 SV=1 PF00610//PF11857//PF03547 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Domain of unknown function (DUF3377)//Membrane transport protein GO:0055085//GO:0035556 transmembrane transport//intracellular signal transduction GO:0004222 metalloendopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.56098 BP_3 64.64 0.62 5311 642919536 XP_008191915.1 146 4.1e-06 PREDICTED: uncharacterized protein LOC103312626 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56099 BP_3 40.13 3.22 893 91084489 XP_971806.1 511 3.2e-49 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.561 BP_3 3.00 0.56 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56100 BP_3 7.02 0.51 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56102 BP_3 14.00 0.38 2063 642920631 XP_008192495.1 194 4.3e-12 PREDICTED: uncharacterized protein LOC103312786 [Tribolium castaneum]>gi|270006078|gb|EFA02526.1| hypothetical protein TcasGA2_TC008231 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56104 BP_3 1.23 0.54 401 817079481 XP_012262159.1 196 4.9e-13 PREDICTED: uncharacterized protein LOC105689597 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56107 BP_3 294.29 13.73 1325 270016479 EFA12925.1 852 1.4e-88 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] 642939405 XM_008195063.1 202 3.02426e-99 PREDICTED: Tribolium castaneum uncharacterized LOC661130 (LOC661130), mRNA -- -- -- -- Q61830 178 8.1e-12 Macrophage mannose receptor 1 OS=Mus musculus GN=Mrc1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56114 BP_3 5.12 0.34 1019 752863744 XP_011268239.1 155 7.0e-08 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56115 BP_3 13.00 0.84 1038 642927192 XP_008195174.1 205 1.1e-13 PREDICTED: centrosomal protein of 104 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56122 BP_3 35.80 0.40 4586 642928360 XP_972133.2 2204 8.1e-245 PREDICTED: ATP-binding cassette sub-family B member 8, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K05655 ABCB8 ATP-binding cassette, subfamily B (MDR/TAP), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K05655 B2GUP8 1544 1.1e-169 ATP-binding cassette sub-family B member 8, mitochondrial OS=Xenopus tropicalis GN=abcb8 PE=2 SV=1 PF00005//PF03193//PF06414//PF01583//PF00664//PF13304//PF12814//PF06472 ABC transporter//Protein of unknown function, DUF258//Zeta toxin//Adenylylsulphate kinase//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Meiotic cell cortex C-terminal pleckstrin homology//ABC transporter transmembrane region 2 GO:0055085//GO:0006810//GO:0032065//GO:0000103//GO:0006144 transmembrane transport//transport//cortical protein anchoring//sulfate assimilation//purine nucleobase metabolic process GO:0016887//GO:0016301//GO:0042626//GO:0005524//GO:0003924//GO:0005525//GO:0004020//GO:0005515//GO:0005543 ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//GTP binding//adenylylsulfate kinase activity//protein binding//phospholipid binding GO:0005938//GO:0016021 cell cortex//integral component of membrane KOG0058 Peptide exporter, ABC superfamily Cluster-8309.56124 BP_3 91.68 0.81 5769 195381919 XP_002049680.1 2495 1.8e-278 GJ20621 [Drosophila virilis]>gi|194144477|gb|EDW60873.1| GJ20621 [Drosophila virilis] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2489 3.7e-279 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00130//PF00564//PF00069//PF07714//PF00628//PF00433//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//PB1 domain//Protein kinase domain//Protein tyrosine kinase//PHD-finger//Protein kinase C terminal domain//C1-like domain GO:0016310//GO:0006468//GO:0009069//GO:0035556//GO:0055114 phosphorylation//protein phosphorylation//serine family amino acid metabolic process//intracellular signal transduction//oxidation-reduction process GO:0005524//GO:0005515//GO:0008270//GO:0047134//GO:0004672//GO:0004674//GO:0046872 ATP binding//protein binding//zinc ion binding//protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity//metal ion binding GO:0005622 intracellular KOG0694 Serine/threonine protein kinase Cluster-8309.56126 BP_3 1.00 2.34 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56129 BP_3 144.70 4.48 1849 546683303 ERL93135.1 687 2.6e-69 hypothetical protein D910_10435 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 476 3.2e-46 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.5613 BP_3 5.00 0.82 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56131 BP_3 306.75 7.48 2268 546683759 ERL93524.1 252 8.9e-19 hypothetical protein D910_10813 [Dendroctonus ponderosae] 642925806 XM_964316.3 202 5.23502e-99 PREDICTED: Tribolium castaneum glycine-rich cell wall structural protein (LOC657888), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56138 BP_3 4.00 0.34 859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03864//PF00171 Phage major capsid protein E//Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity GO:0019028 viral capsid -- -- Cluster-8309.56141 BP_3 138.10 0.78 8845 270014787 EFA11235.1 4479 0.0e+00 hypothetical protein TcasGA2_TC010767 [Tribolium castaneum] 642911510 XM_008201231.1 266 5.46047e-134 PREDICTED: Tribolium castaneum protein unc-79 homolog (LOC662785), mRNA -- -- -- -- Q0KK59 1357 1.0e-147 Protein unc-79 homolog OS=Mus musculus GN=Unc79 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4820 Involved in anesthetic response in C.elegans Cluster-8309.56149 BP_3 3.00 0.55 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56151 BP_3 61.44 0.69 4581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56158 BP_3 301.57 17.61 1117 546683404 ERL93223.1 143 1.9e-06 hypothetical protein D910_10519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03427//PF01093 Carbohydrate binding domain (family 19)//Clusterin GO:0008219//GO:0006032 cell death//chitin catabolic process GO:0008061 chitin binding -- -- -- -- Cluster-8309.56163 BP_3 14.89 0.43 1948 642918266 XP_008191438.1 1555 6.2e-170 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] 755988817 XM_011313677.1 243 7.24386e-122 PREDICTED: Fopius arisanus dual oxidase (LOC105271872), mRNA K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 1515 1.1e-166 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 PF08030//PF00175//PF07340 Ferric reductase NAD binding domain//Oxidoreductase NAD-binding domain//Cytomegalovirus IE1 protein GO:0050792//GO:0055114 regulation of viral process//oxidation-reduction process GO:0016491 oxidoreductase activity GO:0042025 host cell nucleus KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.56164 BP_3 275.29 1.10 12348 270013018 EFA09466.1 7056 0.0e+00 hypothetical protein TcasGA2_TC010960 [Tribolium castaneum] 667677299 AE014296.5 67 3.20728e-23 Drosophila melanogaster chromosome 3L K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8WXX0 4747 0.0e+00 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 PF00158//PF01695//PF07728//PF07724//PF00437//PF00004//PF03028//PF02224//PF01637//PF04851//PF05418//PF00580//PF00910//PF02601 Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor//Cytidylate kinase//Archaeal ATPase//Type III restriction enzyme, res subunit//Apovitellenin I (Apo-VLDL-II)//UvrD/REP helicase N-terminal domain//RNA helicase//Exonuclease VII, large subunit GO:0007018//GO:0006139//GO:0006810//GO:0007017//GO:0006355//GO:0006629//GO:0006206//GO:0006308 microtubule-based movement//nucleobase-containing compound metabolic process//transport//microtubule-based process//regulation of transcription, DNA-templated//lipid metabolic process//pyrimidine nucleobase metabolic process//DNA catabolic process GO:0005524//GO:0016787//GO:0008134//GO:0016887//GO:0004127//GO:0003723//GO:0003677//GO:0004857//GO:0008855//GO:0003777//GO:0003724 ATP binding//hydrolase activity//transcription factor binding//ATPase activity//cytidylate kinase activity//RNA binding//DNA binding//enzyme inhibitor activity//exodeoxyribonuclease VII activity//microtubule motor activity//RNA helicase activity GO:0009318//GO:0042627//GO:0030286//GO:0005667//GO:0005874 exodeoxyribonuclease VII complex//chylomicron//dynein complex//transcription factor complex//microtubule -- -- Cluster-8309.56165 BP_3 16.78 0.66 1518 642928567 XP_008199961.1 577 1.2e-56 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 418 1.4e-39 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.56168 BP_3 32.00 2.73 856 657569009 XP_008287965.1 145 8.5e-07 PREDICTED: sushi domain-containing protein 4-like [Stegastes partitus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5617 BP_3 67.03 1.25 2874 91078746 XP_967966.1 2490 3.5e-278 PREDICTED: kelch-like protein 21 [Tribolium castaneum]>gi|270003745|gb|EFA00193.1| hypothetical protein TcasGA2_TC003018 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- C9JJ37 295 4.8e-25 BTB/POZ domain-containing protein 19 OS=Homo sapiens GN=BTBD19 PE=2 SV=1 PF00651//PF04091 BTB/POZ domain//Exocyst complex subunit Sec15-like GO:0006904 vesicle docking involved in exocytosis GO:0005515 protein binding GO:0000145 exocyst -- -- Cluster-8309.56170 BP_3 343.00 10.19 1914 270001095 EEZ97542.1 150 5.0e-07 hypothetical protein TcasGA2_TC011392 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56171 BP_3 20.00 1.32 1024 817186287 XP_012287640.1 143 1.7e-06 PREDICTED: ABC transporter G family member 20 [Orussus abietinus]>gi|817186289|ref|XP_012287641.1| PREDICTED: ABC transporter G family member 20 [Orussus abietinus]>gi|817186291|ref|XP_012287642.1| PREDICTED: ABC transporter G family member 20 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56175 BP_3 491.39 6.04 4215 478255350 ENN75576.1 1484 2.3e-161 hypothetical protein YQE_07919, partial [Dendroctonus ponderosae] -- -- -- -- -- K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q9VSD7 1226 7.7e-133 Lariat debranching enzyme OS=Drosophila melanogaster GN=ldbr PE=1 SV=1 PF05011//PF00149//PF01507 Lariat debranching enzyme, C-terminal domain//Calcineurin-like phosphoesterase//Phosphoadenosine phosphosulfate reductase family GO:0008152//GO:0006397 metabolic process//mRNA processing GO:0003824//GO:0016788//GO:0016787 catalytic activity//hydrolase activity, acting on ester bonds//hydrolase activity -- -- KOG2863 RNA lariat debranching enzyme Cluster-8309.56176 BP_3 2.00 0.43 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5618 BP_3 10.45 0.49 1319 270014282 EFA10730.1 817 1.6e-84 hypothetical protein TcasGA2_TC012313 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606//PF06766 Ankyrin repeat//Ankyrin repeat//Fungal hydrophobin -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4177 Ankyrin Cluster-8309.56183 BP_3 9.56 1.38 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- B7Z0K8 123 9.1e-06 Collagen alpha chain CG42342 OS=Drosophila melanogaster GN=CG42342 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56187 BP_3 38.71 4.29 727 815923753 XP_012246615.1 338 3.0e-29 PREDICTED: uncharacterized protein CG43427 isoform X1 [Bombus impatiens]>gi|815923755|ref|XP_012246616.1| PREDICTED: uncharacterized protein CG43427 isoform X1 [Bombus impatiens]>gi|815923757|ref|XP_012246617.1| PREDICTED: uncharacterized protein CG43427 isoform X1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q3KQW7 184 9.0e-13 LIM and calponin homology domains-containing protein 1 OS=Xenopus laevis GN=limch1 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.56190 BP_3 43.60 2.73 1062 91080251 XP_973223.1 192 3.8e-12 PREDICTED: 4-nitrophenylphosphatase [Tribolium castaneum]>gi|270005691|gb|EFA02139.1| hypothetical protein TcasGA2_TC007789 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.56191 BP_3 51.96 0.40 6499 546680884 ERL91070.1 2079 3.6e-230 hypothetical protein D910_08412 [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 Q9NSI6 1251 1.5e-135 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens GN=BRWD1 PE=1 SV=4 PF13409//PF00400//PF13417//PF10717//PF06507//PF00439//PF02798 Glutathione S-transferase, N-terminal domain//WD domain, G-beta repeat//Glutathione S-transferase, N-terminal domain//Occlusion-derived virus envelope protein ODV-E18//Auxin response factor//Bromodomain//Glutathione S-transferase, N-terminal domain GO:0006355//GO:0009725 regulation of transcription, DNA-templated//response to hormone GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634//GO:0019031 nucleus//viral envelope KOG0644 Uncharacterized conserved protein, contains WD40 repeat and BROMO domains Cluster-8309.56195 BP_3 6.00 0.40 1014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56196 BP_3 73.00 1.34 2920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56198 BP_3 58.32 1.50 2162 572271659 XP_006613765.1 1557 4.0e-170 PREDICTED: serine/threonine-protein phosphatase 5-like [Apis dorsata] 817223205 XM_012431486.1 171 8.52319e-82 PREDICTED: Orussus abietinus serine/threonine-protein phosphatase 5 (LOC105703243), transcript variant X2, mRNA K04460 PPP5C serine/threonine-protein phosphatase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04460 P53041 1311 5.5e-143 Serine/threonine-protein phosphatase 5 OS=Homo sapiens GN=PPP5C PE=1 SV=1 PF13174//PF10579//PF13181//PF13414//PF13176//PF13371//PF00515//PF00149 Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Calcineurin-like phosphoesterase GO:0007268 synaptic transmission GO:0033130//GO:0016787//GO:0043495//GO:0005515 acetylcholine receptor binding//hydrolase activity//protein anchor//protein binding -- -- KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.5620 BP_3 5.00 1.02 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56200 BP_3 55.71 0.63 4553 642923337 XP_008193707.1 2964 0.0e+00 PREDICTED: uncharacterized protein LOC103313102 [Tribolium castaneum]>gi|270007619|gb|EFA04067.1| hypothetical protein TcasGA2_TC014301 [Tribolium castaneum] 170035242 XM_001845428.1 49 1.19392e-13 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- P22792 295 7.6e-25 Carboxypeptidase N subunit 2 OS=Homo sapiens GN=CPN2 PE=1 SV=3 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.56201 BP_3 139.68 3.31 2325 270003871 EFA00319.1 227 7.2e-16 hypothetical protein TcasGA2_TC003157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56203 BP_3 12.00 1.54 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56216 BP_3 9.00 0.81 830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56219 BP_3 68.00 1.46 2535 189240243 XP_969276.2 786 1.2e-80 PREDICTED: homeobox protein unc-4-like [Tribolium castaneum] 830020422 XM_012759459.1 72 1.08286e-26 PREDICTED: Microcebus murinus UNC homeobox (UNCX), mRNA K09328 UNC4 homeobox protein Unc-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09328 O77215 467 4.8e-45 Homeobox protein unc-4 OS=Drosophila melanogaster GN=unc-4 PE=2 SV=1 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.5622 BP_3 2.00 1.01 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56221 BP_3 1.00 5.92 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56223 BP_3 12.96 0.59 1359 642918767 XP_008191575.1 287 4.6e-23 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9MYY0 258 4.4e-21 Heparanase OS=Bos taurus GN=HPSE PE=2 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.56225 BP_3 27.18 0.35 3994 642920495 XP_969255.3 1368 6.1e-148 PREDICTED: open rectifier potassium channel protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94526 709 6.5e-73 Open rectifier potassium channel protein 1 OS=Drosophila melanogaster GN=Ork1 PE=1 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.56230 BP_3 53.77 0.48 5636 270005719 EFA02167.1 2386 7.8e-266 hypothetical protein TcasGA2_TC007822 [Tribolium castaneum] 645014450 XM_008205260.1 171 2.2433e-81 PREDICTED: Nasonia vitripennis potassium voltage-gated channel subfamily KQT member 1-like (LOC100119507), mRNA K04926 KCNQ1 potassium voltage-gated channel KQT-like subfamily member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04926 O73925 1575 3.5e-173 Potassium voltage-gated channel subfamily KQT member 1 OS=Squalus acanthias GN=KCNQ1 PE=2 SV=1 PF04505//PF00612//PF00520 Interferon-induced transmembrane protein//IQ calmodulin-binding motif//Ion transport protein GO:0055085//GO:0009607//GO:0006811 transmembrane transport//response to biotic stimulus//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1419 Voltage-gated K+ channel KCNQ Cluster-8309.56237 BP_3 24.80 0.50 2694 642919719 XP_008192036.1 1039 5.8e-110 PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919721|ref|XP_008192037.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919723|ref|XP_008192039.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|270005423|gb|EFA01871.1| hypothetical protein TcasGA2_TC007476 [Tribolium castaneum] -- -- -- -- -- K17479 GRXCR1 glutaredoxin domain-containing cysteine-rich protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17479 Q9VNL4 798 2.1e-83 Glutaredoxin domain-containing cysteine-rich protein CG31559 OS=Drosophila melanogaster GN=CG31559 PE=1 SV=2 PF00462 Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG2824 Glutaredoxin-related protein Cluster-8309.56241 BP_3 5.00 0.84 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56242 BP_3 12.00 0.50 1446 694534980 XP_009495189.1 675 5.0e-68 hypothetical protein H696_03028 [Fonticula alba]>gi|627948765|gb|KCV70673.1| hypothetical protein H696_03028 [Fonticula alba] 768311756 CP010984.1 1153 0 Verticillium dahliae VdLs.17 chromosome 5, complete sequence K07750 E1.14.13.72, SC4MOL, ERG25 methylsterol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K07750 O59933 995 1.6e-106 Methylsterol monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG25 PE=3 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0005506//GO:0016491 iron ion binding//oxidoreductase activity -- -- KOG0873 C-4 sterol methyl oxidase Cluster-8309.56243 BP_3 438.60 11.12 2193 642919312 XP_008191821.1 1524 2.7e-166 PREDICTED: periodic tryptophan protein 1 homolog [Tribolium castaneum] 31222365 XM_317168.1 209 6.49834e-103 Anopheles gambiae str. PEST AGAP008298-PA (AgaP_AGAP008298) mRNA, complete cds K14791 PWP1 periodic tryptophan protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14791 Q13610 848 2.7e-89 Periodic tryptophan protein 1 homolog OS=Homo sapiens GN=PWP1 PE=1 SV=1 PF00085//PF01346//PF02966//PF00400 Thioredoxin//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Mitosis protein DIM1//WD domain, G-beta repeat GO:0006457//GO:0045454//GO:0000398 protein folding//cell redox homeostasis//mRNA splicing, via spliceosome GO:0005515 protein binding GO:0005681 spliceosomal complex KOG0270 WD40 repeat-containing protein Cluster-8309.56245 BP_3 32.81 1.06 1783 642927980 XP_008195470.1 937 2.6e-98 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N302 473 6.8e-46 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF01585//PF00498 G-patch domain//FHA domain -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.56246 BP_3 71.92 3.57 1262 642927980 XP_008195470.1 423 7.3e-39 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N302 210 1.5e-15 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.56247 BP_3 220.19 4.16 2845 642927980 XP_008195470.1 937 4.1e-98 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N302 473 1.1e-45 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF00498//PF07851//PF01585 FHA domain//TMPIT-like protein//G-patch domain -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0016021 integral component of membrane KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.56248 BP_3 50.82 1.07 2577 270009850 EFA06298.1 830 9.6e-86 hypothetical protein TcasGA2_TC009165 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N302 437 1.5e-41 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF07851//PF01585//PF00498 TMPIT-like protein//G-patch domain//FHA domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0016021 integral component of membrane KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.56249 BP_3 87.23 1.70 2763 270016510 EFA12956.1 2579 1.6e-288 pumilio [Tribolium castaneum] 795073953 XM_012020518.1 202 6.39114e-99 PREDICTED: Vollenhovia emeryi pumilio homolog 2 (LOC105566474), transcript variant X5, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1302 7.8e-142 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF04627//PF01151//PF00806 CPL (NUC119) domain//Mitochondrial ATP synthase epsilon chain//GNS1/SUR4 family//Pumilio-family RNA binding repeat GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0003723//GO:0046961//GO:0046933 RNA binding//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0000275//GO:0045259//GO:0016021 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex//integral component of membrane KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.5625 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56254 BP_3 6.27 0.66 748 478263235 ENN81624.1 298 1.4e-24 hypothetical protein YQE_01987, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56257 BP_3 46.12 0.78 3152 328701369 XP_003241578.1 565 6.2e-55 PREDICTED: KRAB-A domain-containing protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6R2W3 461 2.9e-44 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.56259 BP_3 285.29 4.36 3446 642931117 XP_008201668.1 644 4.7e-64 PREDICTED: autism susceptibility gene 2 protein isoform X3 [Tribolium castaneum] 642931120 XM_008203448.1 181 3.77123e-87 PREDICTED: Tribolium castaneum autism susceptibility gene 2 protein (LOC655697), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF06273 Plant specific eukaryotic initiation factor 4B GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.56263 BP_3 6.77 0.31 1333 91085531 XP_972280.1 791 1.6e-81 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q8VC97 629 4.1e-64 Beta-ureidopropionase OS=Mus musculus GN=Upb1 PE=2 SV=1 PF00795//PF04055 Carbon-nitrogen hydrolase//Radical SAM superfamily GO:0006807 nitrogen compound metabolic process GO:0003824//GO:0051536//GO:0016810 catalytic activity//iron-sulfur cluster binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0808 Carbon-nitrogen hydrolase Cluster-8309.56266 BP_3 85.45 2.45 1971 642931121 XP_008201670.1 549 2.8e-53 PREDICTED: autism susceptibility gene 2 protein isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5627 BP_3 1.00 0.75 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56273 BP_3 317.00 38.75 686 642930660 XP_001810176.2 428 1.0e-39 PREDICTED: coiled-coil domain-containing protein 115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5628 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56282 BP_3 26.00 1.77 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56283 BP_3 212.57 3.14 3554 642931541 XP_008196629.1 2798 0.0e+00 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 Q76MJ5 1243 7.0e-135 Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Homo sapiens GN=ERN2 PE=1 SV=4 PF06479//PF00804//PF00069//PF06293//PF07714 Ribonuclease 2-5A//Syntaxin//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006397//GO:0044260//GO:0006468//GO:0051252//GO:0044238 mRNA processing//cellular macromolecule metabolic process//protein phosphorylation//regulation of RNA metabolic process//primary metabolic process GO:0005524//GO:0004540//GO:0016773//GO:0004672 ATP binding//ribonuclease activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.56285 BP_3 22.10 0.37 3174 642931541 XP_008196629.1 1430 3.1e-155 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 Q09499 573 3.1e-57 Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=1 SV=2 -- -- GO:0044260//GO:0044238 cellular macromolecule metabolic process//primary metabolic process GO:0004672 protein kinase activity -- -- KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.56287 BP_3 143.22 1.74 4270 478262983 ENN81389.1 782 5.8e-80 hypothetical protein YQE_02205, partial [Dendroctonus ponderosae] -- -- -- -- -- K02321 POLA2 DNA polymerase alpha subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02321 P33611 513 3.7e-50 DNA polymerase alpha subunit B OS=Mus musculus GN=Pola2 PE=1 SV=2 PF12122//PF04042 Cytoplasmic N-terminal domain of rhomboid serine protease//DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003677//GO:0004252//GO:0003887 DNA binding//serine-type endopeptidase activity//DNA-directed DNA polymerase activity GO:0016021//GO:0042575 integral component of membrane//DNA polymerase complex KOG1625 DNA polymerase alpha-primase complex, polymerase-associated subunit B Cluster-8309.56289 BP_3 19.77 2.62 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5629 BP_3 2.00 2.28 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56291 BP_3 10.63 0.42 1502 546672524 ERL84349.1 490 1.5e-46 hypothetical protein D910_01774, partial [Dendroctonus ponderosae] 195134259 XM_002011519.1 48 1.39504e-13 Drosophila mojavensis GI11033 (Dmoj\GI11033), mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.56293 BP_3 117.09 2.49 2556 642916135 XP_008190901.1 765 3.3e-78 PREDICTED: PQ-loop repeat-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N755 308 1.3e-26 PQ-loop repeat-containing protein 3 OS=Homo sapiens GN=PQLC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.56299 BP_3 112.43 0.73 7719 642921556 XP_008192422.1 4628 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TU53 2383 9.8e-267 Cubilin OS=Canis familiaris GN=CUBN PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.56300 BP_3 74.21 10.86 621 189237643 XP_966949.2 768 3.5e-79 PREDICTED: diphthine synthase [Tribolium castaneum] -- -- -- -- -- K00586 DPH5 diphthine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00586 Q9H2P9 635 3.9e-65 Diphthine methyl ester synthase OS=Homo sapiens GN=DPH5 PE=1 SV=2 PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG3123 Diphthine synthase Cluster-8309.56301 BP_3 5.19 4.00 349 546673559 ERL85134.1 307 5.7e-26 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O15027 143 2.4e-08 Protein transport protein Sec16A OS=Homo sapiens GN=SEC16A PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1913 Regucalcin gene promoter region-related protein (RGPR) Cluster-8309.56305 BP_3 1.02 0.32 447 189238453 XP_974381.2 200 1.9e-13 PREDICTED: lysine-specific demethylase 4A [Tribolium castaneum]>gi|270009031|gb|EFA05479.1| hypothetical protein TcasGA2_TC015663 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H3R0 137 1.6e-07 Lysine-specific demethylase 4C OS=Homo sapiens GN=KDM4C PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56306 BP_3 5.52 0.75 646 478261325 ENN80741.1 448 4.7e-42 hypothetical protein YQE_02849, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56312 BP_3 8.68 0.59 1000 642922596 XP_970120.2 453 1.9e-42 PREDICTED: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like [Tribolium castaneum] -- -- -- -- -- K05543 DUS2 tRNA-dihydrouridine synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05543 Q9D7B1 381 1.8e-35 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Mus musculus GN=Dus2 PE=1 SV=1 PF01207 Dihydrouridine synthase (Dus) GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity -- -- KOG2334 tRNA-dihydrouridine synthase Cluster-8309.56314 BP_3 87.36 1.14 3980 642929081 XP_008195683.1 185 9.1e-11 PREDICTED: venom metalloproteinase 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56315 BP_3 118.98 18.60 600 642929078 XP_008195682.1 179 6.8e-11 PREDICTED: venom metalloproteinase 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56316 BP_3 92.66 1.22 3966 642929078 XP_008195682.1 185 9.1e-11 PREDICTED: venom metalloproteinase 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56317 BP_3 1829.32 81.02 1380 642929078 XP_008195682.1 819 9.6e-85 PREDICTED: venom metalloproteinase 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WUQ1 168 1.2e-10 A disintegrin and metalloproteinase with thrombospondin motifs 1 OS=Rattus norvegicus GN=Adamts1 PE=2 SV=1 PF01083//PF01421//PF08516 Cutinase//Reprolysin (M12B) family zinc metalloprotease//ADAM cysteine-rich GO:0008152//GO:0006508 metabolic process//proteolysis GO:0004222//GO:0016787 metalloendopeptidase activity//hydrolase activity -- -- -- -- Cluster-8309.56318 BP_3 66.68 1.85 2025 478249754 ENN70262.1 362 1.4e-31 hypothetical protein YQE_13045, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56319 BP_3 3087.09 93.16 1889 642929081 XP_008195683.1 1459 8.1e-159 PREDICTED: venom metalloproteinase 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5AJT4 177 1.5e-11 Venom metalloproteinase 3 OS=Eulophus pennicornis PE=2 SV=1 PF01562 Reprolysin family propeptide GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.56320 BP_3 24.06 0.80 1749 642917916 XP_008191381.1 687 2.5e-69 PREDICTED: methyltransferase-like protein 17, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U2U7 355 3.2e-32 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF05195//PF02285//PF09243//PF08241 Aminopeptidase P, N-terminal domain//Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22//Methyltransferase domain GO:0006123//GO:0008152//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//metabolic process//translation//proton transport GO:0030145//GO:0004177//GO:0008168//GO:0004129 manganese ion binding//aminopeptidase activity//methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.56321 BP_3 5.13 0.49 793 642939466 XP_008200414.1 335 7.4e-29 PREDICTED: huntingtin-like [Tribolium castaneum] -- -- -- -- -- K04533 HD huntingtin http://www.genome.jp/dbget-bin/www_bget?ko:K04533 P42858 177 6.3e-12 Huntingtin OS=Homo sapiens GN=HTT PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56323 BP_3 82.56 0.62 6756 478260037 ENN79822.1 2747 1.3e-307 hypothetical protein YQE_03645, partial [Dendroctonus ponderosae] 642918140 XM_008193162.1 208 7.27244e-102 PREDICTED: Tribolium castaneum ATP-dependent DNA helicase Q4 (LOC655929), mRNA K10730 RECQL4 ATP-dependent DNA helicase Q4 http://www.genome.jp/dbget-bin/www_bget?ko:K10730 Q75NR7 1479 5.7e-162 ATP-dependent DNA helicase Q4 OS=Mus musculus GN=Recql4 PE=2 SV=2 PF00437//PF00098//PF00270//PF00485//PF00503//PF03193//PF06414//PF04851//PF02367 Type II/IV secretion system protein//Zinc knuckle//DEAD/DEAH box helicase//Phosphoribulokinase / Uridine kinase family//G-protein alpha subunit//Protein of unknown function, DUF258//Zeta toxin//Type III restriction enzyme, res subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0007186//GO:0007165//GO:0006810//GO:0002949//GO:0008152 G-protein coupled receptor signaling pathway//signal transduction//transport//tRNA threonylcarbamoyladenosine modification//metabolic process GO:0019001//GO:0016301//GO:0008270//GO:0016787//GO:0031683//GO:0005524//GO:0003924//GO:0004871//GO:0003676//GO:0005525//GO:0003677 guanyl nucleotide binding//kinase activity//zinc ion binding//hydrolase activity//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//signal transducer activity//nucleic acid binding//GTP binding//DNA binding -- -- KOG0351 ATP-dependent DNA helicase Cluster-8309.56326 BP_3 242.64 12.08 1260 478250982 ENN71466.1 428 1.9e-39 hypothetical protein YQE_11883, partial [Dendroctonus ponderosae]>gi|546682648|gb|ERL92560.1| hypothetical protein D910_09873 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5633 BP_3 5.00 0.41 874 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56330 BP_3 26.41 0.31 4395 270005503 EFA01951.1 634 8.7e-63 hypothetical protein TcasGA2_TC007566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56332 BP_3 64.00 6.76 748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56333 BP_3 35.71 0.39 4674 270009849 EFA06297.1 1167 1.4e-124 hypothetical protein TcasGA2_TC009164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AKG8 300 2.0e-25 Focadhesin OS=Mus musculus GN=Focad PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.56337 BP_3 26.00 0.97 1590 795016637 XP_011858564.1 326 1.6e-27 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03943 TAP C-terminal domain GO:0051028 mRNA transport -- -- GO:0005634 nucleus -- -- Cluster-8309.56338 BP_3 23.00 1.70 942 270014439 EFA10887.1 172 7.0e-10 hypothetical protein TcasGA2_TC001711 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00640//PF02777 Phosphotyrosine interaction domain (PTB/PID)//Iron/manganese superoxide dismutases, C-terminal domain GO:0006801//GO:0055114 superoxide metabolic process//oxidation-reduction process GO:0046872//GO:0005515//GO:0004784 metal ion binding//protein binding//superoxide dismutase activity -- -- -- -- Cluster-8309.5634 BP_3 18.24 0.36 2703 189236336 XP_001816307.1 1527 1.5e-166 PREDICTED: general transcription factor IIH subunit 1 [Tribolium castaneum]>gi|270005862|gb|EFA02310.1| hypothetical protein TcasGA2_TC007976 [Tribolium castaneum] -- -- -- -- -- K03141 TFIIH1, GTF2H1, TFB1 transcription initiation factor TFIIH subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03141 Q960E8 1040 1.8e-111 General transcription factor IIH subunit 1 OS=Drosophila melanogaster GN=Tfb1 PE=2 SV=1 PF07289 Protein of unknown function (DUF1448) -- -- -- -- GO:0034464 BBSome KOG2074 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB1 Cluster-8309.56343 BP_3 114.91 1.37 4348 817324046 XP_012332723.1 243 1.9e-17 PREDICTED: zinc finger protein 808, partial [Aotus nancymaae] 642918101 XM_008195799.1 403 0 PREDICTED: Tribolium castaneum Krueppel-like factor 6 (LOC103313193), transcript variant X1, mRNA K09206 KLF5 krueppel-like factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09206 Q5VIY5 232 1.5e-17 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF10232//PF00471//PF15060//PF00096//PF13465 C2H2-type zinc finger//Mediator of RNA polymerase II transcription complex subunit 8//Ribosomal protein L33//Differentiation and proliferation regulator//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006412//GO:0007275//GO:0042254//GO:0030154//GO:0006357 translation//multicellular organismal development//ribosome biogenesis//cell differentiation//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0046872//GO:0003735 RNA polymerase II transcription cofactor activity//metal ion binding//structural constituent of ribosome GO:0016592//GO:0005622//GO:0005840 mediator complex//intracellular//ribosome -- -- Cluster-8309.56344 BP_3 3.00 0.47 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56346 BP_3 642.67 6.83 4827 642937760 XP_008198934.1 1304 1.9e-140 PREDICTED: mortality factor 4-like protein 1 [Tribolium castaneum]>gi|270001152|gb|EEZ97599.1| hypothetical protein TcasGA2_TC011468 [Tribolium castaneum] 807018879 XM_004519732.2 70 2.68358e-25 PREDICTED: Ceratitis capitata nuA4 complex subunit EAF3 homolog (LOC101448544), mRNA K11339 MORF4L1, MRG15, EAF3 mortality factor 4-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11339 Q6AYU1 950 9.0e-101 Mortality factor 4-like protein 1 OS=Rattus norvegicus GN=Morf4l1 PE=2 SV=1 PF01080//PF05485 Presenilin//THAP domain -- -- GO:0004190//GO:0003676 aspartic-type endopeptidase activity//nucleic acid binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.5635 BP_3 3.33 0.46 638 665806052 XP_008551249.1 296 2.0e-24 PREDICTED: U1 small nuclear ribonucleoprotein A [Microplitis demolitor] 259016064 GQ265634.1 59 4.41027e-20 Muscidifurax raptorellus voucher NCSU:BMW DTOL-803 sans fille (SNF) mRNA, partial cds K11094 SNRPB2 U2 small nuclear ribonucleoprotein B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11094 P43332 267 1.9e-22 U1 small nuclear ribonucleoprotein A OS=Drosophila melanogaster GN=snf PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4206 Spliceosomal protein snRNP-U1A/U2B Cluster-8309.56352 BP_3 15.28 0.47 1845 642917175 XP_008191150.1 448 1.3e-41 PREDICTED: pangolin isoform X2 [Tribolium castaneum] 55832417 AY800246.1 233 2.48258e-116 Tribolium castaneum pangolin gene, partial cds -- -- -- -- -- -- -- -- PF10538 Immunoreceptor tyrosine-based activation motif GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.56353 BP_3 25.14 0.33 3919 795015467 XP_011858161.1 353 3.0e-30 PREDICTED: uncharacterized protein LOC105555728, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q5M8X6 130 8.8e-06 Collectin-10 OS=Xenopus tropicalis GN=colec10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56360 BP_3 2.00 0.56 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56361 BP_3 10.00 1.19 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56363 BP_3 101.64 1.78 3041 8648963 CAB94835.1 2359 5.7e-263 heterochromatin protein [Leptinotarsa decemlineata] 749745767 XM_011136632.1 88 1.65954e-35 PREDICTED: Harpegnathos saltator eukaryotic translation initiation factor 2 subunit 3, Y-linked (LOC105180525), mRNA K11419 SUV39H, CLR4 histone-lysine N-methyltransferase SUV39H http://www.genome.jp/dbget-bin/www_bget?ko:K11419 Q32PH7 758 1.0e-78 Histone-lysine N-methyltransferase SUV39H2 OS=Bos taurus GN=SUV39H2 PE=2 SV=1 PF00856//PF05033 SET domain//Pre-SET motif GO:0006479//GO:0034968//GO:0006554 protein methylation//histone lysine methylation//lysine catabolic process GO:0008270//GO:0018024//GO:0005515 zinc ion binding//histone-lysine N-methyltransferase activity//protein binding GO:0005634 nucleus KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing Cluster-8309.56364 BP_3 148.30 1.08 6918 102939 1499 6.8e-163 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1174 1.4e-126 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03310//PF13683//PF00665//PF02966 Caulimovirus DNA-binding protein//Integrase core domain//Integrase core domain//Mitosis protein DIM1 GO:0015074//GO:0000398 DNA integration//mRNA splicing, via spliceosome GO:0003677 DNA binding GO:0005681 spliceosomal complex -- -- Cluster-8309.56365 BP_3 276.00 17.14 1068 91083427 XP_969334.1 411 1.5e-37 PREDICTED: M-phase phosphoprotein 6 [Tribolium castaneum]>gi|270006891|gb|EFA03339.1| hypothetical protein TcasGA2_TC013316 [Tribolium castaneum] -- -- -- -- -- K12593 MPHOSPH6, MPP6 M-phase phosphoprotein 6, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K12593 Q9D1Q1 183 1.7e-12 M-phase phosphoprotein 6 OS=Mus musculus GN=Mphosph6 PE=1 SV=1 PF04615 Utp14 protein GO:0006364 rRNA processing -- -- GO:0032040 small-subunit processome -- -- Cluster-8309.56367 BP_3 6.00 0.38 1062 642915518 XP_968660.2 176 2.7e-10 PREDICTED: syntaxin-8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56369 BP_3 2.00 0.75 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5637 BP_3 7.00 0.31 1365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56371 BP_3 415.31 12.77 1859 91084211 XP_968214.1 901 4.0e-94 PREDICTED: transcriptional adapter 3 [Tribolium castaneum]>gi|270008765|gb|EFA05213.1| hypothetical protein TcasGA2_TC015353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66IZ5 351 9.9e-32 Transcriptional adapter 3-B OS=Xenopus laevis GN=tada3-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56373 BP_3 13.78 0.67 1285 642936409 XP_008198421.1 466 7.7e-44 PREDICTED: APOPT family protein CG14806, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q148E1 284 4.0e-24 Apoptogenic protein 1, mitochondrial OS=Bos taurus GN=APOPT1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4094 Uncharacterized conserved protein Cluster-8309.56378 BP_3 90.73 0.51 8935 642914669 XP_008190307.1 831 2.5e-85 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 401 7.6e-37 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF05631//PF07690//PF00083 Sugar-tranasporters, 12 TM//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0015689 transmembrane transport//molybdate ion transport GO:0022857//GO:0015098 transmembrane transporter activity//molybdate ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.56381 BP_3 16.58 0.93 1149 646705170 KDR13037.1 288 3.0e-23 hypothetical protein L798_13305 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W3T5 273 6.8e-23 Small integral membrane protein 4 OS=Drosophila melanogaster GN=CG32736 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56382 BP_3 48.76 3.49 966 795016637 XP_011858564.1 860 1.2e-89 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56383 BP_3 15.24 1.29 860 795016637 XP_011858564.1 631 3.8e-63 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56384 BP_3 207.70 2.35 4553 478257774 ENN77917.1 1941 2.5e-214 hypothetical protein YQE_05594, partial [Dendroctonus ponderosae] -- -- -- -- -- K17573 LKAP, MARF1 meiosis arrest female protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17573 E1BP74 764 3.1e-79 Meiosis arrest female protein 1 OS=Bos taurus GN=MARF1 PE=3 SV=2 PF02196//PF00076 Raf-like Ras-binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0007165 signal transduction GO:0003676//GO:0005057 nucleic acid binding//receptor signaling protein activity -- -- -- -- Cluster-8309.56385 BP_3 259.74 2.29 5766 478257774 ENN77917.1 2916 0.0e+00 hypothetical protein YQE_05594, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B2GUN4 1110 3.0e-119 Meiosis arrest female protein 1 homolog OS=Xenopus tropicalis GN=marf1 PE=2 SV=1 PF00106//PF00076 short chain dehydrogenase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0008152 metabolic process GO:0003676//GO:0016491 nucleic acid binding//oxidoreductase activity -- -- -- -- Cluster-8309.56386 BP_3 50.49 0.55 4679 642928750 XP_008199767.1 2930 0.0e+00 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] 642928749 XM_008201545.1 658 0 PREDICTED: Tribolium castaneum uncharacterized LOC663132 (LOC663132), mRNA -- -- -- -- O60500 211 4.3e-15 Nephrin OS=Homo sapiens GN=NPHS1 PE=1 SV=1 PF00001//PF05808//PF13895 7 transmembrane receptor (rhodopsin family)//Podoplanin//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.56388 BP_3 43.35 3.80 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5639 BP_3 76.65 1.45 2835 91084979 XP_972279.1 462 4.9e-43 PREDICTED: U6 snRNA-associated Sm-like protein LSm8 [Tribolium castaneum]>gi|270009009|gb|EFA05457.1| hypothetical protein TcasGA2_TC015638 [Tribolium castaneum] -- -- -- -- -- K12627 LSM8 U6 snRNA-associated Sm-like protein LSm8 http://www.genome.jp/dbget-bin/www_bget?ko:K12627 Q3ZCE0 354 6.8e-32 U6 snRNA-associated Sm-like protein LSm8 OS=Bos taurus GN=LSM8 PE=3 SV=3 PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane KOG1784 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.56395 BP_3 31.89 2.11 1019 546672885 ERL84608.1 577 8.2e-57 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P36189 473 3.9e-46 Fatty acid synthase (Fragment) OS=Anser anser anser GN=FASN PE=1 SV=1 PF05038//PF00211//PF05052//PF08545//PF00108 Cytochrome Cytochrome b558 alpha-subunit//Adenylate and Guanylate cyclase catalytic domain//MerE protein//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0008152//GO:0006633//GO:0035556//GO:0009190//GO:0015694 acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process//intracellular signal transduction//cyclic nucleotide biosynthetic process//mercury ion transport GO:0004315//GO:0016747//GO:0016849//GO:0020037//GO:0015097 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups//phosphorus-oxygen lyase activity//heme binding//mercury ion transmembrane transporter activity GO:0005835//GO:0016020 fatty acid synthase complex//membrane KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.56397 BP_3 19.28 0.51 2113 73765582 AAZ85125.1 1069 1.5e-113 Down Syndrome adhesion molecule splice variant 3.12.3.1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS29 460 2.6e-44 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56399 BP_3 2.00 0.89 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56400 BP_3 22.99 0.58 2213 478259929 ENN79731.1 375 4.7e-33 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 214 9.1e-16 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006412//GO:0015992//GO:0006123 translation//proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.56401 BP_3 43.24 1.11 2176 642937652 XP_966876.3 559 2.1e-54 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N4W9 383 2.3e-35 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF02150//PF13465//PF00096//PF01096 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS) GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0003676//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//nucleic acid binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.56402 BP_3 55.94 1.53 2055 642937652 XP_966876.3 559 2.0e-54 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N4W9 383 2.1e-35 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF07776//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.56406 BP_3 52.61 6.27 696 91080703 XP_975295.1 321 2.7e-27 PREDICTED: uncharacterized protein LOC664189 [Tribolium castaneum]>gi|270005858|gb|EFA02306.1| hypothetical protein TcasGA2_TC007972 [Tribolium castaneum] 462358939 APGK01029925.1 54 2.90918e-17 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56410 BP_3 25.92 1.50 1126 170321839 BAG14264.1 445 1.8e-41 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q6DIV5 153 5.4e-09 Inactive serine protease PAMR1 OS=Xenopus tropicalis GN=pamr1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.56412 BP_3 8.97 1.27 632 642918224 XP_008191419.1 789 1.3e-81 PREDICTED: transcription initiation factor TFIID subunit 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K03125 TAF1 transcription initiation factor TFIID subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03125 P51123 430 2.3e-41 Transcription initiation factor TFIID subunit 1 OS=Drosophila melanogaster GN=Taf1 PE=1 SV=3 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG0008 Transcription initiation factor TFIID, subunit TAF1 Cluster-8309.56413 BP_3 84.05 0.86 5009 478253546 ENN73864.1 968 1.8e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.76116e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 9.7e-82 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF06814//PF01529 Peptidase family M50//Lung seven transmembrane receptor//DHHC palmitoyltransferase GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG2585 Uncharacterized conserved protein Cluster-8309.56417 BP_3 64.33 0.80 4150 546679163 ERL89665.1 531 7.2e-51 hypothetical protein D910_07028 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V4P1 243 7.4e-19 Actin-binding protein anillin OS=Drosophila melanogaster GN=scra PE=1 SV=3 PF03232//PF07544 Ubiquinone biosynthesis protein COQ7//RNA polymerase II transcription mediator complex subunit 9 GO:0006357//GO:0006744//GO:0055114 regulation of transcription from RNA polymerase II promoter//ubiquinone biosynthetic process//oxidation-reduction process GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.5642 BP_3 71.21 3.08 1407 642923081 XP_970728.2 443 3.9e-41 PREDICTED: aquaporin NIP1-2-like [Tribolium castaneum] -- -- -- -- -- K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q25074 367 1.0e-33 Aquaporin OS=Haematobia irritans exigua PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.56421 BP_3 5.05 0.31 1089 270012506 EFA08954.1 534 8.5e-52 hypothetical protein TcasGA2_TC006661 [Tribolium castaneum] 768434472 XM_011560346.1 37 1.30741e-07 PREDICTED: Plutella xylostella atrial natriuretic peptide receptor 1 (LOC105389255), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18293 380 2.5e-35 Atrial natriuretic peptide receptor 1 OS=Mus musculus GN=Npr1 PE=2 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.56423 BP_3 622.65 200.34 441 642917566 XP_008191259.1 276 2.8e-22 PREDICTED: transmembrane protein 258-like [Tribolium castaneum]>gi|642939410|ref|XP_008193314.1| PREDICTED: transmembrane protein 258 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q76LT9 249 1.6e-20 Transmembrane protein 258 OS=Gallus gallus GN=TMEM258 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4452 Predicted membrane protein Cluster-8309.56427 BP_3 89.01 1.97 2467 861641895 KMQ93718.1 1401 5.6e-152 serine threonine-protein kinase 36 [Lasius niger] -- -- -- -- -- K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 P23647 840 2.6e-88 Serine/threonine-protein kinase fused OS=Drosophila melanogaster GN=fu PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0580 Serine/threonine protein kinase Cluster-8309.56428 BP_3 31.67 0.80 2205 861641895 KMQ93718.1 1267 1.7e-136 serine threonine-protein kinase 36 [Lasius niger] 817083926 XM_012409166.1 66 2.03457e-23 PREDICTED: Athalia rosae serine/threonine-protein kinase fused (LOC105690966), transcript variant X2, mRNA K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 P23647 867 1.7e-91 Serine/threonine-protein kinase fused OS=Drosophila melanogaster GN=fu PE=1 SV=2 PF07714//PF00069//PF06293//PF10598 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//RNA recognition motif of the spliceosomal PrP8 GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0003723//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//RNA binding//protein kinase activity GO:0016020 membrane KOG0580 Serine/threonine protein kinase Cluster-8309.56429 BP_3 671.64 6.98 4927 642917533 XP_008191243.1 1114 2.1e-118 PREDICTED: myosin-3 [Tribolium castaneum] 462291896 APGK01053945.1 99 2.07336e-41 Dendroctonus ponderosae Seq01053955, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56431 BP_3 1.96 0.39 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56433 BP_3 9.66 0.70 960 478263078 ENN81478.1 540 1.5e-52 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IN81 289 7.9e-25 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56435 BP_3 106.66 1.34 4130 478263078 ENN81478.1 1060 3.3e-112 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IN81 289 3.4e-24 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00376//PF00196//PF00651//PF13411 MerR family regulatory protein//Bacterial regulatory proteins, luxR family//BTB/POZ domain//MerR HTH family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.56437 BP_3 11.00 2.07 548 91084819 XP_973299.1 230 7.6e-17 PREDICTED: protein abrupt [Tribolium castaneum]>gi|270008590|gb|EFA05038.1| hypothetical protein TcasGA2_TC015126 [Tribolium castaneum] 642925929 XM_968206.2 79 2.86057e-31 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q9W0K4 148 1.0e-08 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF10186//PF08802 Vacuolar sorting 38 and autophagy-related subunit 14//Cytochrome B6-F complex Fe-S subunit GO:0006118//GO:0010508//GO:0055114 obsolete electron transport//positive regulation of autophagy//oxidation-reduction process GO:0051537//GO:0009496 2 iron, 2 sulfur cluster binding//plastoquinol--plastocyanin reductase activity GO:0042651//GO:0009512 thylakoid membrane//cytochrome b6f complex -- -- Cluster-8309.56443 BP_3 4.00 0.42 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56446 BP_3 12.07 0.38 1818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56449 BP_3 199.80 4.00 2699 642918316 XP_008191456.1 959 1.1e-100 PREDICTED: proline-, glutamic acid- and leucine-rich protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZL8 169 1.8e-10 Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens GN=PELP1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5645 BP_3 4.00 0.57 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56452 BP_3 40.36 0.40 5152 751234819 XP_011171162.1 994 1.8e-104 PREDICTED: uncharacterized protein LOC105203928 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- Q7M3K2 364 8.5e-33 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF06221//PF05485 Putative zinc finger motif, C2HC5-type//THAP domain GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.56453 BP_3 211.00 2.51 4346 326670210 XP_003199161.1 1945 8.2e-215 PREDICTED: uncharacterized protein K02A2.6-like [Danio rerio] -- -- -- -- -- -- -- -- -- P0CT36 758 1.5e-78 Transposon Tf2-3 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-3 PE=1 SV=1 PF00665//PF00098 Integrase core domain//Zinc knuckle GO:0015074 DNA integration GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.56458 BP_3 652.84 4.74 6930 270014766 EFA11214.1 3269 0.0e+00 hypothetical protein TcasGA2_TC005178 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.25817e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q9UP95 2270 1.1e-253 Solute carrier family 12 member 4 OS=Homo sapiens GN=SLC12A4 PE=1 SV=2 PF05038//PF03522//PF00324//PF13520 Cytochrome Cytochrome b558 alpha-subunit//Solute carrier family 12//Amino acid permease//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0003333//GO:0006811 transmembrane transport//amino acid transport//transport//amino acid transmembrane transport//ion transport GO:0015171//GO:0005215//GO:0020037 amino acid transmembrane transporter activity//transporter activity//heme binding GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.56459 BP_3 36.34 0.90 2241 91081053 XP_975382.1 563 7.6e-55 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270005322|gb|EFA01770.1| hypothetical protein TcasGA2_TC007369 [Tribolium castaneum] -- -- -- -- -- K00019 E1.1.1.30, bdh 3-hydroxybutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00019 P29147 150 2.4e-08 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Bdh1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.56475 BP_3 60.03 1.76 1933 91086011 XP_972761.1 2152 3.6e-239 PREDICTED: uncharacterized protein LOC661513 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08300 Hepatitis C virus non-structural 5a zinc finger domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.56477 BP_3 41.00 2.06 1252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03126 Plus-3 domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.56478 BP_3 1.00 2.40 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56479 BP_3 118.03 1.94 3222 189235122 XP_001811652.1 2006 5.1e-222 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 422 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1600 2.5e-176 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF02724//PF03612//PF08496//PF04277//PF00856//PF01496 CDC45-like protein//Sorbitol phosphotransferase enzyme II N-terminus//Peptidase family S49 N-terminal//Oxaloacetate decarboxylase, gamma chain//SET domain//V-type ATPase 116kDa subunit family GO:0008643//GO:0006560//GO:0015991//GO:0006814//GO:0071436//GO:0006090//GO:0009401//GO:0015992//GO:0006525//GO:0006270 carbohydrate transport//proline metabolic process//ATP hydrolysis coupled proton transport//sodium ion transport//sodium ion export//pyruvate metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system//proton transport//arginine metabolic process//DNA replication initiation GO:0008982//GO:0015081//GO:0005515//GO:0015078//GO:0003682//GO:0004252//GO:0008948 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//sodium ion transmembrane transporter activity//protein binding//hydrogen ion transmembrane transporter activity//chromatin binding//serine-type endopeptidase activity//oxaloacetate decarboxylase activity GO:0016020//GO:0033179//GO:0000785//GO:0005886//GO:0009357//GO:0016021 membrane//proton-transporting V-type ATPase, V0 domain//chromatin//plasma membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG1079 Transcriptional repressor EZH1 Cluster-8309.56480 BP_3 2.00 0.36 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56482 BP_3 5.00 0.48 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56483 BP_3 15.10 1.20 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56486 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56487 BP_3 24.73 0.35 3730 642913362 XP_008195422.1 235 1.4e-16 PREDICTED: uncharacterized protein LOC103313584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56490 BP_3 42.59 1.18 2031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56493 BP_3 63.41 0.93 3572 91084963 XP_971862.1 1094 3.2e-116 PREDICTED: GPI mannosyltransferase 4 [Tribolium castaneum]>gi|270009003|gb|EFA05451.1| hypothetical protein TcasGA2_TC015632 [Tribolium castaneum] -- -- -- -- -- K08098 PIGZ, SMP3 phosphatidylinositol glycan, class Z http://www.genome.jp/dbget-bin/www_bget?ko:K08098 Q8MT80 638 1.0e-64 GPI mannosyltransferase 4 OS=Drosophila melanogaster GN=CG45068 PE=2 SV=1 PF04428//PF03901 Choline kinase N terminus//Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016773//GO:0016757 phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG4123 Putative alpha 1,2 mannosyltransferase Cluster-8309.56494 BP_3 543.14 11.00 2672 642931697 XP_008196692.1 1336 2.1e-144 PREDICTED: uncharacterized protein LOC657740 isoform X1 [Tribolium castaneum]>gi|270012781|gb|EFA09229.1| stem cell tumour protein [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P20350 547 2.7e-54 Protein rhomboid OS=Drosophila melanogaster GN=rho PE=1 SV=2 PF01694 Rhomboid family GO:0006508 proteolysis GO:0004252//GO:0005509 serine-type endopeptidase activity//calcium ion binding GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.56501 BP_3 149.13 3.68 2247 642925984 XP_008194718.1 973 2.2e-102 PREDICTED: sugar phosphate exchanger 2 isoform X3 [Tribolium castaneum]>gi|642925986|ref|XP_008194719.1| PREDICTED: sugar phosphate exchanger 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 591 1.8e-59 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF02293//PF07690 AmiS/UreI family transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.56506 BP_3 15.00 0.65 1398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56507 BP_3 90.53 3.08 1709 189164166 ACD77184.1 1560 1.4e-170 putative hepatocyte nuclear factor 4 nuclear hormone receptor [Callosobruchus maculatus] 189164165 EU545256.1 377 0 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1240 7.5e-135 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.56508 BP_3 3.07 0.54 564 642919019 XP_008191698.1 351 7.3e-31 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08236 SRI (Set2 Rpb1 interacting) domain GO:0006355//GO:0006479//GO:0034968//GO:0006554 regulation of transcription, DNA-templated//protein methylation//histone lysine methylation//lysine catabolic process GO:0018024 histone-lysine N-methyltransferase activity GO:0005694 chromosome -- -- Cluster-8309.56509 BP_3 23.71 0.58 2261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56512 BP_3 76.28 0.43 8752 -- -- -- -- -- 642938285 XM_008194514.1 89 1.33776e-35 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF09477 Bacterial type II secretion system chaperone protein (type_III_yscG) GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.56522 BP_3 27.53 0.47 3108 189239121 XP_001815551.1 590 7.8e-58 PREDICTED: lysM and putative peptidoglycan-binding domain-containing protein 2 [Tribolium castaneum]>gi|270010334|gb|EFA06782.1| hypothetical protein TcasGA2_TC009718 [Tribolium castaneum] 766919473 XM_011505860.1 143 4.52099e-66 PREDICTED: Ceratosolen solmsi marchali transcription initiation factor IIA subunit 2 (LOC105367226), mRNA K03123 TFIIA2, GTF2A2, TOA2 transcription initiation factor TFIIA small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03123 P52656 467 5.9e-45 Transcription initiation factor IIA subunit 2 OS=Drosophila melanogaster GN=TfIIA-S PE=1 SV=1 PF02268//PF02751 Transcription initiation factor IIA, gamma subunit, helical domain//Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex KOG3463 Transcription initiation factor IIA, gamma subunit Cluster-8309.56525 BP_3 816.19 52.43 1042 91077040 XP_967879.1 577 8.4e-57 PREDICTED: signal recognition particle 19 kDa protein [Tribolium castaneum]>gi|270001745|gb|EEZ98192.1| hypothetical protein TcasGA2_TC000621 [Tribolium castaneum] -- -- -- -- -- K03105 SRP19 signal recognition particle subunit SRP19 http://www.genome.jp/dbget-bin/www_bget?ko:K03105 P49963 413 3.6e-39 Signal recognition particle 19 kDa protein OS=Drosophila melanogaster GN=Srp19 PE=2 SV=2 PF01922 SRP19 protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle KOG3198 Signal recognition particle, subunit Srp19 Cluster-8309.56526 BP_3 9.00 0.62 987 641663663 XP_008182723.1 411 1.4e-37 PREDICTED: uncharacterized protein LOC103309327 [Acyrthosiphon pisum]>gi|641679805|ref|XP_008188719.1| PREDICTED: uncharacterized protein LOC103310986 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity -- -- KOG4585 Predicted transposase Cluster-8309.56529 BP_3 21.45 0.44 2662 741960905 XP_010813664.1 443 7.4e-41 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 208-like [Bos taurus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NQZ8 422 8.3e-40 Endothelial zinc finger protein induced by tumor necrosis factor alpha OS=Homo sapiens GN=ZNF71 PE=2 SV=1 PF13465//PF01363//PF13912//PF02892//PF16622//PF00096//PF00130//PF02148//PF07776//PF05715 Zinc-finger double domain//FYVE zinc finger//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zn-finger in ubiquitin-hydrolases and other protein//Zinc-finger associated domain (zf-AD)//Piccolo Zn-finger GO:0035556 intracellular signal transduction GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0045202//GO:0005634 synapse//nucleus -- -- Cluster-8309.56536 BP_3 91.55 2.56 2014 91089225 XP_968001.1 340 4.9e-29 PREDICTED: PRKR-interacting protein 1 homolog [Tribolium castaneum]>gi|270011471|gb|EFA07919.1| hypothetical protein TcasGA2_TC005495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNG8 221 1.3e-16 PRKR-interacting protein 1 homolog OS=Xenopus laevis GN=prkrip1 PE=2 SV=1 PF02862//PF04999 DDHD domain//Cell division protein FtsL GO:0051301//GO:0007049 cell division//cell cycle GO:0046872 metal ion binding GO:0016021 integral component of membrane KOG4055 Uncharacterized conserved protein Cluster-8309.56540 BP_3 26.01 0.84 1777 270007007 EFA03455.1 144 2.3e-06 hypothetical protein TcasGA2_TC013448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06397 Desulfoferrodoxin, N-terminal domain -- -- GO:0005506 iron ion binding -- -- -- -- Cluster-8309.56545 BP_3 18.58 0.95 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56546 BP_3 65.71 0.74 4577 546674380 ERL85767.1 2461 1.3e-274 hypothetical protein D910_03182 [Dendroctonus ponderosae] 641673871 XM_001952487.3 196 2.3037e-95 PREDICTED: Acyrthosiphon pisum uncharacterized LOC100160518 (LOC100160518), partial mRNA -- -- -- -- Q29441 837 1.1e-87 Cyclic nucleotide-gated cation channel alpha-3 OS=Bos taurus GN=CNGA3 PE=2 SV=1 PF00520//PF03938 Ion transport protein//Outer membrane protein (OmpH-like) GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0051082//GO:0005216 unfolded protein binding//ion channel activity GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.56550 BP_3 532.46 17.73 1739 91084991 XP_972796.1 1236 5.4e-133 PREDICTED: serine palmitoyltransferase 1 [Tribolium castaneum]>gi|270009012|gb|EFA05460.1| hypothetical protein TcasGA2_TC015642 [Tribolium castaneum] -- -- -- -- -- K00654 SPT serine palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00654 P91079 707 4.8e-73 Serine palmitoyltransferase 1 OS=Caenorhabditis elegans GN=sptl-1 PE=3 SV=1 PF00155//PF01053 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1358 Serine palmitoyltransferase Cluster-8309.56552 BP_3 476.00 16.13 1714 91082987 XP_974250.1 774 2.0e-79 PREDICTED: uncharacterized protein LOC663096 [Tribolium castaneum]>gi|270007031|gb|EFA03479.1| hypothetical protein TcasGA2_TC013478 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02735 Ku70/Ku80 beta-barrel domain GO:0006303 double-strand break repair via nonhomologous end joining GO:0003677 DNA binding -- -- -- -- Cluster-8309.56558 BP_3 110.77 1.04 5405 164698398 NP_001106936.1 2335 6.1e-260 timeless isoform B [Tribolium castaneum]>gi|140270876|gb|ABO86541.1| TIMELESS isoform B [Tribolium castaneum] -- -- -- -- -- K12074 TIM timeless http://www.genome.jp/dbget-bin/www_bget?ko:K12074 P49021 1599 5.6e-176 Protein timeless OS=Drosophila melanogaster GN=tim PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56560 BP_3 231.93 2.78 4320 91092158 XP_967537.1 1880 2.8e-207 PREDICTED: steroid receptor seven-up, isoforms B/C [Tribolium castaneum]>gi|270015100|gb|EFA11548.1| seven up [Tribolium castaneum] 145228045 EF372598.1 535 0 Callosobruchus maculatus COUP-TF/Svp nuclear hormone receptor (Svp) mRNA, complete cds K08547 NR2F1, TFCOUP1 COUP transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08547 P16375 1629 1.5e-179 Steroid receptor seven-up, isoforms B/C OS=Drosophila melanogaster GN=svp PE=2 SV=1 PF14554//PF00105//PF02736//PF00104 VEGF heparin-binding domain//Zinc finger, C4 type (two domains)//Myosin N-terminal SH3-like domain//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355//GO:0007165//GO:0030522 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction//intracellular receptor signaling pathway GO:0043565//GO:0008270//GO:0008201//GO:0003700//GO:0005524//GO:0003774//GO:0046872//GO:0003707//GO:0004879 sequence-specific DNA binding//zinc ion binding//heparin binding//transcription factor activity, sequence-specific DNA binding//ATP binding//motor activity//metal ion binding//steroid hormone receptor activity//RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0016459//GO:0005634//GO:0005667 myosin complex//nucleus//transcription factor complex -- -- Cluster-8309.56563 BP_3 11.00 0.58 1200 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56564 BP_3 101.05 1.23 4255 642918699 XP_008191544.1 1540 7.4e-168 PREDICTED: protein sprint isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 632 5.9e-64 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.56574 BP_3 2.00 0.81 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56575 BP_3 14.00 0.39 2003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56577 BP_3 97.52 1.33 3838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04216 Protein involved in formate dehydrogenase formation -- -- -- -- GO:0005737 cytoplasm -- -- Cluster-8309.56579 BP_3 17.73 0.37 2593 332373134 AEE61708.1 893 4.8e-93 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00913 ITPK1 inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00913 Q13572 460 3.2e-44 Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens GN=ITPK1 PE=1 SV=2 PF07065//PF05770//PF02106 D123//Inositol 1, 3, 4-trisphosphate 5/6-kinase//Fanconi anaemia group C protein GO:0007049//GO:0032957//GO:0006281 cell cycle//inositol trisphosphate metabolic process//DNA repair GO:0000287//GO:0052725//GO:0047325//GO:0005524//GO:0052726 magnesium ion binding//inositol-1,3,4-trisphosphate 6-kinase activity//inositol tetrakisphosphate 1-kinase activity//ATP binding//inositol-1,3,4-trisphosphate 5-kinase activity GO:0005622 intracellular -- -- Cluster-8309.56580 BP_3 44.70 0.95 2550 91081993 XP_969039.1 1700 1.2e-186 PREDICTED: KDEL motif-containing protein 1 [Tribolium castaneum]>gi|270007375|gb|EFA03823.1| hypothetical protein TcasGA2_TC013938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UW63 1169 1.9e-126 KDEL motif-containing protein 1 OS=Homo sapiens GN=KDELC1 PE=1 SV=1 PF05353 Delta Atracotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.56581 BP_3 33.95 0.69 2674 91081993 XP_969039.1 1700 1.3e-186 PREDICTED: KDEL motif-containing protein 1 [Tribolium castaneum]>gi|270007375|gb|EFA03823.1| hypothetical protein TcasGA2_TC013938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UW63 1169 2.0e-126 KDEL motif-containing protein 1 OS=Homo sapiens GN=KDELC1 PE=1 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.56583 BP_3 4.75 0.34 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56584 BP_3 257.92 3.04 4386 478263044 ENN81444.1 2454 7.9e-274 hypothetical protein YQE_02137, partial [Dendroctonus ponderosae] -- -- -- -- -- K10902 RECQL5 ATP-dependent DNA helicase Q5 http://www.genome.jp/dbget-bin/www_bget?ko:K10902 Q8VID5 1195 3.2e-129 ATP-dependent DNA helicase Q5 OS=Mus musculus GN=Recql5 PE=2 SV=1 PF04851//PF08236//PF00270//PF00437 Type III restriction enzyme, res subunit//SRI (Set2 Rpb1 interacting) domain//DEAD/DEAH box helicase//Type II/IV secretion system protein GO:0034968//GO:0006810//GO:0006554//GO:0006355//GO:0006479 histone lysine methylation//transport//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005524//GO:0016787//GO:0003677//GO:0018024//GO:0003676 ATP binding//hydrolase activity//DNA binding//histone-lysine N-methyltransferase activity//nucleic acid binding GO:0005694 chromosome KOG0351 ATP-dependent DNA helicase Cluster-8309.56585 BP_3 237.98 9.28 1528 91077324 XP_974759.1 978 3.9e-103 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270001669|gb|EEZ98116.1| hypothetical protein TcasGA2_TC000534 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q5SPD7 522 1.2e-51 Pyrroline-5-carboxylate reductase 3 OS=Danio rerio GN=pycrl PE=2 SV=1 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006561//GO:0006525//GO:0006098//GO:0055114//GO:0019521 proline biosynthetic process//arginine metabolic process//pentose-phosphate shunt//oxidation-reduction process//D-gluconate metabolic process GO:0004735//GO:0004616//GO:0000166 pyrroline-5-carboxylate reductase activity//phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.56589 BP_3 1024.49 10.11 5176 642927107 XP_008195140.1 6577 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Tribolium castaneum] 642927106 XM_008196918.1 476 0 PREDICTED: Tribolium castaneum sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (LOC660611), mRNA -- -- -- -- Q22328 982 1.9e-104 Protein lev-9 OS=Caenorhabditis elegans GN=lev-9 PE=1 SV=3 PF02793//PF00095 Hormone receptor domain//WAP-type (Whey Acidic Protein) 'four-disulfide core' GO:0007186 G-protein coupled receptor signaling pathway GO:0030414//GO:0004930 peptidase inhibitor activity//G-protein coupled receptor activity GO:0016020//GO:0005576 membrane//extracellular region KOG4297 C-type lectin Cluster-8309.56592 BP_3 67.50 1.13 3166 546679741 ERL90152.1 1418 7.7e-154 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96RT8 416 4.9e-39 Gamma-tubulin complex component 5 OS=Homo sapiens GN=TUBGCP5 PE=1 SV=1 PF04130//PF04505 Spc97 / Spc98 family//Interferon-induced transmembrane protein GO:0009607//GO:0000226//GO:0090063 response to biotic stimulus//microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0000922//GO:0005815//GO:0016021 spindle pole//microtubule organizing center//integral component of membrane -- -- Cluster-8309.56596 BP_3 782.88 9.43 4292 546674526 ERL85886.1 4701 0.0e+00 hypothetical protein D910_03301 [Dendroctonus ponderosae] -- -- -- -- -- K14312 NUP155, NUP170, NUP157 nuclear pore complex protein Nup155 http://www.genome.jp/dbget-bin/www_bget?ko:K14312 Q99P88 2301 1.8e-257 Nuclear pore complex protein Nup155 OS=Mus musculus GN=Nup155 PE=1 SV=1 PF04454//PF06433//PF05184 Encapsulating protein for peroxidase//Methylamine dehydrogenase heavy chain (MADH)//Saposin-like type B, region 1 GO:0006629//GO:0055114//GO:0042742//GO:0015947 lipid metabolic process//oxidation-reduction process//defense response to bacterium//methane metabolic process GO:0008233//GO:0030058 peptidase activity//amine dehydrogenase activity GO:0042597 periplasmic space KOG1900 Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170) Cluster-8309.5660 BP_3 17.00 0.45 2120 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56603 BP_3 47.57 0.48 5094 478257469 ENN77625.1 988 9.0e-104 hypothetical protein YQE_05919, partial [Dendroctonus ponderosae]>gi|546679863|gb|ERL90251.1| hypothetical protein D910_07603 [Dendroctonus ponderosae] -- -- -- -- -- K11502 CENPJ centromere protein J http://www.genome.jp/dbget-bin/www_bget?ko:K11502 Q5BQN8 469 5.6e-45 Centromere protein J OS=Pan troglodytes GN=CENPJ PE=2 SV=1 PF05531//PF16331//PF00170//PF01091//PF02531//PF06305//PF01395//PF04136//PF15898 Nucleopolyhedrovirus P10 protein//TolA binding protein trimerisation//bZIP transcription factor//PTN/MK heparin-binding protein family, C-terminal domain//PsaD//Protein of unknown function (DUF1049)//PBP/GOBP family//Sec34-like family//cGMP-dependent protein kinase interacting domain GO:0007165//GO:0070206//GO:0006886//GO:0006355//GO:0040007//GO:0015979//GO:0008283 signal transduction//protein trimerization//intracellular protein transport//regulation of transcription, DNA-templated//growth//photosynthesis//cell proliferation GO:0005549//GO:0043565//GO:0019901//GO:0003700//GO:0008083 odorant binding//sequence-specific DNA binding//protein kinase binding//transcription factor activity, sequence-specific DNA binding//growth factor activity GO:0019028//GO:0005887//GO:0009522//GO:0009538//GO:0005801//GO:0005667//GO:0016020 viral capsid//integral component of plasma membrane//photosystem I//photosystem I reaction center//cis-Golgi network//transcription factor complex//membrane -- -- Cluster-8309.56605 BP_3 17.03 0.46 2058 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00081//PF11411 Iron/manganese superoxide dismutases, alpha-hairpin domain//DNA ligase IV GO:0006281//GO:0055114//GO:0006260//GO:0006801 DNA repair//oxidation-reduction process//DNA replication//superoxide metabolic process GO:0004784//GO:0003910//GO:0046872 superoxide dismutase activity//DNA ligase (ATP) activity//metal ion binding -- -- -- -- Cluster-8309.56606 BP_3 142.21 1.03 6921 642928264 XP_969418.2 1644 1.0e-179 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q2NL14 660 5.4e-67 KAT8 regulatory NSL complex subunit 2 OS=Bos taurus GN=KANSL2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.56608 BP_3 280.89 2.41 5898 189237665 XP_001812360.1 414 3.8e-37 PREDICTED: RNA-binding protein 34 [Tribolium castaneum]>gi|270007816|gb|EFA04264.1| hypothetical protein TcasGA2_TC014554 [Tribolium castaneum] -- -- -- -- -- K14837 NOP12 nucleolar protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14837 Q6CKV6 265 2.9e-21 Nucleolar protein 12 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=NOP12 PE=3 SV=2 PF04258//PF00076//PF16367//PF07525 Signal peptide peptidase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//SOCS box GO:0035556 intracellular signal transduction GO:0004190//GO:0003676 aspartic-type endopeptidase activity//nucleic acid binding GO:0016021 integral component of membrane KOG0118 FOG: RRM domain Cluster-8309.56611 BP_3 271.99 2.92 4783 642911232 XP_008199678.1 2029 1.6e-224 PREDICTED: uncharacterized protein LOC661025 isoform X5 [Tribolium castaneum] 642911231 XM_008201456.1 94 1.21111e-38 PREDICTED: Tribolium castaneum nuclear protein MDM1 (LOC661025), transcript variant X6, mRNA -- -- -- -- Q5ZMW6 134 3.7e-06 Nuclear protein MDM1 OS=Gallus gallus GN=MDM1 PE=2 SV=1 PF15501 Nuclear protein MDM1 -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.56612 BP_3 18.44 0.41 2467 478260635 ENN80338.1 354 1.4e-30 hypothetical protein YQE_03330, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56625 BP_3 35.16 0.35 5105 558231171 XP_006139245.1 413 4.3e-37 PREDICTED: uncharacterized protein LOC102453386 [Pelodiscus sinensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 383 5.3e-35 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF13912//PF16622//PF10590//PF13465//PF00096//PF06397 C2H2-type zinc finger//zinc-finger C2H2-type//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Zinc-finger double domain//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain GO:0055114 oxidation-reduction process GO:0005506//GO:0016638//GO:0046872 iron ion binding//oxidoreductase activity, acting on the CH-NH2 group of donors//metal ion binding -- -- -- -- Cluster-8309.56628 BP_3 24.47 0.44 2988 642921592 XP_008192437.1 380 1.7e-33 PREDICTED: peptidyl-prolyl cis-trans isomerase D [Tribolium castaneum]>gi|270005014|gb|EFA01462.1| hypothetical protein TcasGA2_TC007008 [Tribolium castaneum] -- -- -- -- -- K05864 PPID, CYPD peptidyl-prolyl isomerase D http://www.genome.jp/dbget-bin/www_bget?ko:K05864 Q9CR16 295 5.0e-25 Peptidyl-prolyl cis-trans isomerase D OS=Mus musculus GN=Ppid PE=1 SV=3 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.56629 BP_3 13.00 1.70 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56631 BP_3 6.00 1.18 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56637 BP_3 27.00 0.31 4477 759063479 XP_011341114.1 253 1.3e-18 PREDICTED: uncharacterized protein LOC105281531 isoform X2 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07378//PF05405 Flagellar protein FlbT//Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015986//GO:0006402//GO:1902209//GO:0015992 ATP synthesis coupled proton transport//mRNA catabolic process//negative regulation of bacterial-type flagellum assembly//proton transport GO:0015078//GO:0048027 hydrogen ion transmembrane transporter activity//mRNA 5'-UTR binding -- -- -- -- Cluster-8309.5664 BP_3 2.55 0.65 480 307179877 EFN68034.1 150 1.3e-07 Zinc finger protein 569 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q6PGE4 140 7.4e-08 Zinc finger protein 316 OS=Mus musculus GN=Znf316 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56643 BP_3 99.05 5.68 1133 270011728 EFA08176.1 138 7.3e-06 hypothetical protein TcasGA2_TC005803 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56648 BP_3 13.33 0.69 1227 91084687 XP_968830.1 341 2.3e-29 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050 Flagellar FliJ protein GO:0071973//GO:0006935 bacterial-type flagellum-dependent cell motility//chemotaxis GO:0003774 motor activity GO:0009288//GO:0016020 bacterial-type flagellum//membrane -- -- Cluster-8309.56649 BP_3 29.23 0.76 2135 642938263 XP_008198135.1 1516 2.2e-165 PREDICTED: rho GTPase-activating protein 19 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INE5 272 1.6e-22 Rho GTPase-activating protein 19 OS=Xenopus laevis GN=arhgap19 PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.56650 BP_3 7.68 0.55 967 546675442 ERL86630.1 393 1.7e-35 hypothetical protein D910_04037 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVE2 293 2.7e-25 Protein rogdi OS=Drosophila melanogaster GN=rogdi PE=1 SV=2 PF05320 Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.56670 BP_3 12.14 0.38 1838 546685412 ERL94925.1 567 2.1e-55 hypothetical protein D910_12197 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.56672 BP_3 8.00 0.46 1139 270001526 EEZ97973.1 746 2.3e-76 hypothetical protein TcasGA2_TC000368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.56675 BP_3 131.79 4.40 1737 546671410 ERL83733.1 739 2.3e-75 hypothetical protein D910_00946 [Dendroctonus ponderosae]>gi|546671482|gb|ERL83777.1| hypothetical protein D910_01015 [Dendroctonus ponderosae]>gi|546671488|gb|ERL83781.1| hypothetical protein D910_01019 [Dendroctonus ponderosae] -- -- -- -- -- K10990 RMI1, BRAP75 RecQ-mediated genome instability protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10990 Q7ZVM9 410 1.3e-38 RecQ-mediated genome instability protein 1 OS=Danio rerio GN=rmi1 PE=2 SV=1 PF16099 Recq-mediated genome instability protein 1, C-terminal OB-fold -- -- GO:0000166 nucleotide binding -- -- KOG3683 Uncharacterized conserved protein Cluster-8309.56676 BP_3 12.29 0.74 1097 642912988 XP_008201341.1 169 1.8e-09 PREDICTED: uncharacterized protein LOC103315160 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01086 Clathrin light chain GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198 structural molecule activity GO:0030130//GO:0030132 clathrin coat of trans-Golgi network vesicle//clathrin coat of coated pit -- -- Cluster-8309.56677 BP_3 39.10 3.69 802 282158097 NP_001164092.1 453 1.5e-42 quaking related [Tribolium castaneum] -- -- -- -- -- K14942 KHDRBS3, SLM2 KH domain-containing, RNA-binding, signal transduction-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14942 Q0VFL3 135 4.8e-07 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Xenopus tropicalis GN=khdrbs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5668 BP_3 3.00 0.71 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56680 BP_3 38.00 17.79 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56698 BP_3 2.00 0.82 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56704 BP_3 954.06 23.39 2258 642923111 XP_008193614.1 2166 1.0e-240 PREDICTED: dnaJ homolog subfamily C member 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09531 DNAJC11 DnaJ homolog subfamily C member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09531 Q5U458 1212 1.7e-131 DnaJ homolog subfamily C member 11 OS=Mus musculus GN=Dnajc11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0718 Molecular chaperone (DnaJ superfamily) Cluster-8309.56706 BP_3 34.77 1.69 1281 91082061 XP_972013.1 763 2.8e-78 PREDICTED: nucleoporin NUP53 [Tribolium castaneum]>gi|270007411|gb|EFA03859.1| hypothetical protein TcasGA2_TC013975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFH5 259 3.2e-21 Nucleoporin NUP53 OS=Homo sapiens GN=NUP35 PE=1 SV=1 PF02458 Transferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG4285 Mitotic phosphoprotein Cluster-8309.56707 BP_3 16.00 0.38 2332 642936329 XP_008198398.1 1296 8.0e-140 PREDICTED: hemicentin-2-like isoform X2 [Tribolium castaneum] 642936328 XM_008200176.1 353 0 PREDICTED: Tribolium castaneum hemicentin-2-like (LOC657829), transcript variant X2, mRNA -- -- -- -- Q62718 140 3.6e-07 Neurotrimin OS=Rattus norvegicus GN=Ntm PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56709 BP_3 57.30 5.06 838 91076370 XP_967715.1 482 7.0e-46 PREDICTED: ras-related protein Rab-27A [Tribolium castaneum]>gi|270002552|gb|EEZ98999.1| hypothetical protein TcasGA2_TC004860 [Tribolium castaneum] -- -- -- -- -- K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 Q4LE85 296 1.1e-25 Ras-related protein Rab-27A OS=Sus scrofa GN=RAB27A PE=2 SV=1 PF08477//PF01926//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525 GTP binding -- -- KOG0081 GTPase Rab27, small G protein superfamily Cluster-8309.56712 BP_3 37.20 0.64 3076 642937115 XP_008198698.1 1875 7.6e-207 PREDICTED: uncharacterized protein LOC103314418 [Tribolium castaneum]>gi|270000875|gb|EEZ97322.1| hypothetical protein TcasGA2_TC011133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00004//PF07088//PF00580 ATPase family associated with various cellular activities (AAA)//GvpD gas vesicle protein//UvrD/REP helicase N-terminal domain -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.56713 BP_3 8.16 0.39 1297 270004891 EFA01339.1 179 1.5e-10 hypothetical protein TcasGA2_TC003708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56718 BP_3 79.16 1.56 2745 91082057 XP_971798.1 1924 1.4e-212 PREDICTED: mitochondrial chaperone BCS1 [Tribolium castaneum]>gi|270007281|gb|EFA03729.1| hypothetical protein TcasGA2_TC013838 [Tribolium castaneum] 815794844 XM_012362642.1 161 3.93076e-76 PREDICTED: Linepithema humile mitochondrial chaperone BCS1 (LOC105669594), mRNA K08900 BCS1 mitochondrial chaperone BCS1 http://www.genome.jp/dbget-bin/www_bget?ko:K08900 Q7ZV60 1367 2.3e-149 Mitochondrial chaperone BCS1 OS=Danio rerio GN=bcs1l PE=2 SV=2 PF00004//PF00910//PF06431//PF07728//PF00005 ATPase family associated with various cellular activities (AAA)//RNA helicase//Polyomavirus large T antigen C-terminus//AAA domain (dynein-related subfamily)//ABC transporter GO:0006260 DNA replication GO:0016887//GO:0003677//GO:0003723//GO:0005524//GO:0003724//GO:0017111 ATPase activity//DNA binding//RNA binding//ATP binding//RNA helicase activity//nucleoside-triphosphatase activity -- -- KOG0743 AAA+-type ATPase Cluster-8309.56720 BP_3 70.83 8.16 710 478257530 ENN77685.1 853 5.7e-89 hypothetical protein YQE_05835, partial [Dendroctonus ponderosae]>gi|546677864|gb|ERL88616.1| hypothetical protein D910_06001 [Dendroctonus ponderosae] 734646087 XM_010753864.1 176 4.50229e-85 PREDICTED: Larimichthys crocea protein phosphatase 2, regulatory subunit B', delta (ppp2r5d), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q14738 805 8.6e-85 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens GN=PPP2R5D PE=1 SV=1 PF01603 Protein phosphatase 2A regulatory B subunit (B56 family) GO:0007165 signal transduction GO:0008601 protein phosphatase type 2A regulator activity GO:0000159 protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.56722 BP_3 271.89 16.54 1084 642926763 XP_008195004.1 273 1.5e-21 PREDICTED: dolichol-phosphate mannosyltransferase subunit 3 [Tribolium castaneum]>gi|270008398|gb|EFA04846.1| hypothetical protein TcasGA2_TC014898 [Tribolium castaneum] -- -- -- -- -- K09659 DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09659 Q9P2X0 166 1.6e-10 Dolichol-phosphate mannosyltransferase subunit 3 OS=Homo sapiens GN=DPM3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56726 BP_3 32.94 0.41 4168 91087949 XP_972541.1 1172 3.4e-125 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 384 3.3e-35 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF13202//PF01694//PF00036//PF12763//PF10591//PF03839//PF13833//PF13405//PF13499 EF hand//Rhomboid family//EF hand//Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//Translocation protein Sec62//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0015031//GO:0007165 protein transport//signal transduction GO:0004252//GO:0005509//GO:0008565//GO:0005515 serine-type endopeptidase activity//calcium ion binding//protein transporter activity//protein binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.56728 BP_3 7.32 0.87 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.56731 BP_3 38.57 2.91 931 270007802 EFA04250.1 244 3.1e-18 hypothetical protein TcasGA2_TC014504 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56732 BP_3 32.16 1.33 1461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00317 Ribonucleotide reductase, all-alpha domain GO:0055114//GO:0006260//GO:0006206//GO:0006144//GO:0009186 oxidation-reduction process//DNA replication//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process GO:0004748//GO:0005524 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//ATP binding GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-8309.56733 BP_3 89.81 1.33 3548 641647749 XP_008179485.1 964 3.8e-101 PREDICTED: uncharacterized protein LOC103308217 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- B0BN95 130 8.0e-06 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 PF04928//PF03776//PF04827//PF01609 Poly(A) polymerase central domain//Septum formation topological specificity factor MinE//Plant transposon protein//Transposase DDE domain GO:0032955//GO:0051301//GO:0006313//GO:0043631 regulation of barrier septum assembly//cell division//transposition, DNA-mediated//RNA polyadenylation GO:0004803//GO:0016788//GO:0004652//GO:0003677 transposase activity//hydrolase activity, acting on ester bonds//polynucleotide adenylyltransferase activity//DNA binding -- -- -- -- Cluster-8309.56735 BP_3 39.73 1.13 1987 576249490 AHH29251.1 1416 8.2e-154 Inebriated-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 1077 6.9e-116 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF13520//PF01384//PF00209 Amino acid permease//Phosphate transporter family//Sodium:neurotransmitter symporter family GO:0006865//GO:0006836//GO:0006817//GO:0006812//GO:0003333 amino acid transport//neurotransmitter transport//phosphate ion transport//cation transport//amino acid transmembrane transport GO:0015171//GO:0005328//GO:0005315 amino acid transmembrane transporter activity//neurotransmitter:sodium symporter activity//inorganic phosphate transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.56736 BP_3 1.00 0.77 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56743 BP_3 286.70 4.29 3514 642919497 XP_008191896.1 2896 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56746 BP_3 42.19 0.93 2487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56752 BP_3 7.00 0.52 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56753 BP_3 28.66 0.52 2960 478260052 ENN79837.1 483 1.9e-45 hypothetical protein YQE_03659, partial [Dendroctonus ponderosae]>gi|546676810|gb|ERL87756.1| hypothetical protein D910_05145 [Dendroctonus ponderosae] 556754727 XM_005972665.1 93 2.6831e-38 PREDICTED: Pantholops hodgsonii TRK-fused gene (TFG), mRNA K09292 TFG protein TFG http://www.genome.jp/dbget-bin/www_bget?ko:K09292 Q92734 420 1.6e-39 Protein TFG OS=Homo sapiens GN=TFG PE=1 SV=2 PF00564 PB1 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56757 BP_3 9.00 0.56 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56758 BP_3 4.02 0.34 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56761 BP_3 38.47 0.34 5712 642913824 XP_008201175.1 211 1.3e-13 PREDICTED: microtubule-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05296//PF00643 Taste receptor protein (TAS2R)//B-box zinc finger GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0008270//GO:0004930 zinc ion binding//G-protein coupled receptor activity GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.56764 BP_3 27.59 1.95 972 270014145 EFA10593.1 276 6.2e-22 hypothetical protein TcasGA2_TC012853 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WTR0 143 6.8e-08 Matrix metalloproteinase-16 OS=Mus musculus GN=Mmp16 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56767 BP_3 4.32 0.69 594 478263234 ENN81623.1 510 2.8e-49 hypothetical protein YQE_01986, partial [Dendroctonus ponderosae] 195495540 XM_002095275.1 89 8.60415e-37 Drosophila yakuba GE19764 (Dyak\GE19764), partial mRNA K08819 CDK12_13 cyclin-dependent kinase 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K08819 Q9VP22 467 1.1e-45 Cyclin-dependent kinase 12 OS=Drosophila melanogaster GN=Cdk12 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.5677 BP_3 1.00 2.52 287 -- -- -- -- -- 470488862 NR_076891.1 284 1.55449e-145 Oligotropha carboxidovorans strain OM4 23S ribosomal RNA gene, complete sequence >gnl|BL_ORD_ID|14494855 Oligotropha carboxidovorans strain OM5 23S ribosomal RNA gene, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56770 BP_3 51.09 1.30 2179 801399331 XP_012060168.1 159 5.2e-08 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56771 BP_3 107.91 2.79 2159 801399331 XP_012060168.1 159 5.1e-08 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08686 PLAC (protease and lacunin) domain -- -- GO:0008233 peptidase activity -- -- -- -- Cluster-8309.56777 BP_3 3.00 14.61 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56781 BP_3 302.44 6.04 2705 642922702 XP_008193287.1 1703 5.9e-187 PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922704|ref|XP_008193288.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922706|ref|XP_008193289.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922708|ref|XP_008193290.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N695 750 7.8e-78 Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=2 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.56782 BP_3 11.00 0.66 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02891 MIZ/SP-RING zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.56783 BP_3 14.87 0.46 1862 478263026 ENN81426.1 141 5.4e-06 hypothetical protein YQE_02120, partial [Dendroctonus ponderosae]>gi|546686068|gb|ERL95468.1| hypothetical protein D910_12730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56785 BP_3 235.30 2.57 4704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56787 BP_3 115.06 4.68 1478 189235566 XP_970111.2 987 3.4e-104 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q9JIA7 196 7.4e-14 Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2 PF00781 Diacylglycerol kinase catalytic domain GO:0007205//GO:0009395//GO:0046486 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process GO:0004143//GO:0016301 diacylglycerol kinase activity//kinase activity -- -- KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.5679 BP_3 9.00 0.31 1679 674304034 AIL23548.1 225 8.9e-16 glutathione S-transferase sigma [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 O18598 191 3.2e-13 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.56791 BP_3 113.52 5.56 1275 332373512 AEE61897.1 1119 1.5e-119 unknown [Dendroctonus ponderosae]>gi|478261742|gb|ENN80889.1| hypothetical protein YQE_02678, partial [Dendroctonus ponderosae]>gi|546674326|gb|ERL85730.1| hypothetical protein D910_03145 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 Q9VKH6 888 3.6e-94 Lysosomal thioesterase PPT2 homolog OS=Drosophila melanogaster GN=Ppt2 PE=2 SV=1 PF01674//PF02089 Lipase (class 2)//Palmitoyl protein thioesterase -- -- GO:0098599//GO:0016787 palmitoyl hydrolase activity//hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.56792 BP_3 52.60 0.36 7255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56795 BP_3 9.90 0.32 1764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14144//PF00220 Seed dormancy control//Neurohypophysial hormones, N-terminal Domain GO:0007218//GO:0006351 neuropeptide signaling pathway//transcription, DNA-templated GO:0043565//GO:0005185 sequence-specific DNA binding//neurohypophyseal hormone activity GO:0005576 extracellular region -- -- Cluster-8309.56804 BP_3 18.34 0.33 2937 642915284 XP_008190555.1 1571 1.3e-171 PREDICTED: DNA-binding protein D-ETS-3 isoform X1 [Tribolium castaneum] 642915285 XM_967896.3 282 2.29449e-143 PREDICTED: Tribolium castaneum DNA-binding protein D-ETS-3 (LOC661753), transcript variant X2, mRNA K09436 FLI1 friend leukemia integration 1 transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09436 P29774 881 5.5e-93 DNA-binding protein D-ETS-3 OS=Drosophila melanogaster GN=Ets65A PE=2 SV=3 PF00178//PF00447 Ets-domain//HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3806 Predicted transcription factor Cluster-8309.56806 BP_3 55.15 0.95 3077 91087699 XP_974256.1 900 8.7e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 6.0e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.5681 BP_3 2.00 0.98 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56813 BP_3 52.02 0.65 4158 642939403 XP_008193263.1 1963 6.4e-217 PREDICTED: protein FAM135A [Tribolium castaneum]>gi|270016463|gb|EFA12909.1| hypothetical protein TcasGA2_TC006979 [Tribolium castaneum] 642939402 XM_008195041.1 369 0 PREDICTED: Tribolium castaneum protein FAM135A (LOC661082), mRNA -- -- -- -- Q5RA75 1083 2.9e-116 Protein FAM135A OS=Pongo abelii GN=FAM135A PE=2 SV=1 PF07819 PGAP1-like protein GO:0006505//GO:0006886 GPI anchor metabolic process//intracellular protein transport GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2205 Uncharacterized conserved protein Cluster-8309.56814 BP_3 2.00 2.54 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56815 BP_3 30.54 0.64 2589 91078782 XP_969464.1 1762 8.1e-194 PREDICTED: differentially expressed in FDCP 8 homolog [Tribolium castaneum]>gi|270004105|gb|EFA00553.1| hypothetical protein TcasGA2_TC003420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTT9 888 7.4e-94 Differentially expressed in FDCP 8 homolog OS=Drosophila melanogaster GN=CG11534 PE=1 SV=1 PF00130//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0008270//GO:0046872//GO:0047134 zinc ion binding//metal ion binding//protein-disulfide reductase activity GO:0005622 intracellular KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.56819 BP_3 12.00 0.69 1132 270015830 EFA12278.1 385 1.7e-34 hypothetical protein TcasGA2_TC005263 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02668 Taurine catabolism dioxygenase TauD, TfdA family GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.56821 BP_3 142.99 6.89 1292 546681611 ERL91675.1 1223 1.3e-131 hypothetical protein D910_09003 [Dendroctonus ponderosae] -- -- -- -- -- K03143 TFIIH3, GTF2H3, TFB4 transcription initiation factor TFIIH subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03143 Q561R7 745 1.4e-77 General transcription factor IIH subunit 3 OS=Rattus norvegicus GN=Gtf2h3 PE=2 SV=1 PF03850//PF07809 Transcription factor Tfb4//RTP801 C-terminal region GO:0009968//GO:0006355//GO:0006289 negative regulation of signal transduction//regulation of transcription, DNA-templated//nucleotide-excision repair -- -- GO:0000439//GO:0005737 core TFIIH complex//cytoplasm KOG2487 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 Cluster-8309.56822 BP_3 187.93 5.60 1910 642940135 XP_008191977.1 2067 2.6e-229 PREDICTED: probable tyrosyl-DNA phosphodiesterase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10862 TDP1 tyrosyl-DNA phosphodiesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10862 Q9VQM4 913 6.9e-97 Probable tyrosyl-DNA phosphodiesterase OS=Drosophila melanogaster GN=gkt PE=2 SV=1 PF06087 Tyrosyl-DNA phosphodiesterase GO:0006281 DNA repair GO:0008081 phosphoric diester hydrolase activity GO:0005634 nucleus KOG2031 Tyrosyl-DNA phosphodiesterase Cluster-8309.56825 BP_3 9.41 0.77 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56826 BP_3 11.76 0.36 1882 270015871 EFA12319.1 1171 2.0e-125 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P08487 714 8.1e-74 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Bos taurus GN=PLCG1 PE=1 SV=1 PF00387//PF00168 Phosphatidylinositol-specific phospholipase C, Y domain//C2 domain GO:0046339//GO:0007165//GO:0009395//GO:0035556//GO:0006629 diacylglycerol metabolic process//signal transduction//phospholipid catabolic process//intracellular signal transduction//lipid metabolic process GO:0004435//GO:0005515 phosphatidylinositol phospholipase C activity//protein binding -- -- KOG1264 Phospholipase C Cluster-8309.56828 BP_3 24.71 0.65 2123 478258345 ENN78464.1 1166 8.6e-125 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 763 1.9e-79 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF13304//PF00664 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.56832 BP_3 16.57 1.09 1025 546677066 ERL87975.1 717 4.8e-73 hypothetical protein D910_05363 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 560 3.2e-56 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56834 BP_3 17.39 0.79 1348 642923855 XP_008193907.1 283 1.3e-22 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum] 642923854 XM_008195685.1 81 5.64708e-32 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 -- -- -- -- PF09182 Bacterial purine repressor, N-terminal GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.56835 BP_3 186.94 6.83 1611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56838 BP_3 61.70 1.22 2737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15734 Migration and invasion-inhibitory GO:0010972//GO:0030336 negative regulation of G2/M transition of mitotic cell cycle//negative regulation of cell migration -- -- -- -- -- -- Cluster-8309.56840 BP_3 14.91 0.40 2074 823414642 XP_012414974.1 348 6.0e-30 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 26-like [Trichechus manatus latirostris] 533131911 XM_005380929.1 41 1.50957e-09 PREDICTED: Chinchilla lanigera zinc finger protein 133 (Znf133), transcript variant X9, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8NEP9 299 1.2e-25 Zinc finger protein 555 OS=Homo sapiens GN=ZNF555 PE=1 SV=4 PF01780//PF05715//PF00096//PF05191//PF16622//PF13912//PF02765//PF05443//PF13465//PF06689 Ribosomal L37ae protein family//Piccolo Zn-finger//Zinc finger, C2H2 type//Adenylate kinase, active site lid//zinc-finger C2H2-type//C2H2-type zinc finger//Telomeric single stranded DNA binding POT1/CDC13//ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//ClpX C4-type zinc finger GO:0006355//GO:0042254//GO:0046034//GO:0000723//GO:0006412//GO:0006144 regulation of transcription, DNA-templated//ribosome biogenesis//ATP metabolic process//telomere maintenance//translation//purine nucleobase metabolic process GO:0008270//GO:0003735//GO:0004017//GO:0046872//GO:0003677//GO:0046983 zinc ion binding//structural constituent of ribosome//adenylate kinase activity//metal ion binding//DNA binding//protein dimerization activity GO:0005622//GO:0005840//GO:0045202//GO:0000784 intracellular//ribosome//synapse//nuclear chromosome, telomeric region -- -- Cluster-8309.56842 BP_3 36.77 1.16 1817 637369105 XP_008121693.1 548 3.4e-53 PREDICTED: oocyte zinc finger protein XlCOF6-like isoform X2 [Anolis carolinensis] 533131911 XM_005380929.1 41 1.3193e-09 PREDICTED: Chinchilla lanigera zinc finger protein 133 (Znf133), transcript variant X9, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 517 5.5e-51 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13912//PF16866//PF05191//PF01780//PF00096//PF13465 C2H2-type zinc finger//PHD-finger//Adenylate kinase, active site lid//Ribosomal L37ae protein family//Zinc finger, C2H2 type//Zinc-finger double domain GO:0042254//GO:0006144//GO:0046034//GO:0006412 ribosome biogenesis//purine nucleobase metabolic process//ATP metabolic process//translation GO:0003735//GO:0004017//GO:0046872//GO:0005515 structural constituent of ribosome//adenylate kinase activity//metal ion binding//protein binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.56845 BP_3 27.85 0.46 3187 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56846 BP_3 6.00 0.31 1235 861624759 KMQ88359.1 975 7.0e-103 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P04323 463 6.8e-45 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.56847 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56849 BP_3 21.77 0.77 1659 642923261 XP_008193681.1 1290 2.8e-139 PREDICTED: T-cell activation inhibitor, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 422 5.2e-40 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56855 BP_3 1260.32 35.09 2023 642936688 XP_008198537.1 382 6.7e-34 PREDICTED: uncharacterized protein LOC655388 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56862 BP_3 15.92 0.48 1875 861627332 KMQ89049.1 196 2.3e-12 hypothetical protein RF55_11358 [Lasius niger] -- -- -- -- -- -- -- -- -- P0CT36 128 7.2e-06 Transposon Tf2-3 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56864 BP_3 590.68 48.90 874 150416589 ABF60888.2 165 4.2e-09 putative glycine-rich protein [Leptinotarsa decemlineata]>gi|157649942|gb|ABV59365.1| glycine-rich protein variant 2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.56865 BP_3 276.49 3.33 4289 478263078 ENN81478.1 1060 3.4e-112 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] 642925929 XM_968206.2 108 1.7902e-46 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q8IN81 289 3.5e-24 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF13411//PF00651//PF00196//PF00376 MerR HTH family regulatory protein//BTB/POZ domain//Bacterial regulatory proteins, luxR family//MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.56866 BP_3 44.48 0.54 4277 478263078 ENN81478.1 1060 3.4e-112 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] 642925929 XM_968206.2 108 1.78515e-46 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q8IN81 289 3.5e-24 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00376//PF00196//PF00651//PF13411 MerR family regulatory protein//Bacterial regulatory proteins, luxR family//BTB/POZ domain//MerR HTH family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.56867 BP_3 9.00 0.76 866 91084819 XP_973299.1 230 1.2e-16 PREDICTED: protein abrupt [Tribolium castaneum]>gi|270008590|gb|EFA05038.1| hypothetical protein TcasGA2_TC015126 [Tribolium castaneum] 642925929 XM_968206.2 79 4.63034e-31 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q9W0K4 148 1.6e-08 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF08802 Cytochrome B6-F complex Fe-S subunit GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0051537//GO:0009496 2 iron, 2 sulfur cluster binding//plastoquinol--plastocyanin reductase activity GO:0042651//GO:0009512 thylakoid membrane//cytochrome b6f complex -- -- Cluster-8309.56869 BP_3 74.18 2.60 1666 751215591 XP_011160707.1 146 1.3e-06 PREDICTED: DNA ligase 1-like [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06374//PF01015 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)//Ribosomal S3Ae family GO:0015992//GO:0042254//GO:0006744//GO:0006814//GO:0006412//GO:0006120 proton transport//ribosome biogenesis//ubiquinone biosynthetic process//sodium ion transport//translation//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003735 NADH dehydrogenase (ubiquinone) activity//structural constituent of ribosome GO:0005622//GO:0005840//GO:0005743 intracellular//ribosome//mitochondrial inner membrane -- -- Cluster-8309.56872 BP_3 9.74 0.38 1538 91087273 XP_975542.1 540 2.4e-52 PREDICTED: guanine nucleotide-binding protein subunit beta-5 [Tribolium castaneum]>gi|270009547|gb|EFA05995.1| hypothetical protein TcasGA2_TC008821 [Tribolium castaneum] 807025222 XM_004523529.2 71 2.34146e-26 PREDICTED: Ceratitis capitata guanine nucleotide-binding protein subunit beta-5 (LOC101456443), mRNA K04539 GNB5 guanine nucleotide-binding protein subunit beta-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04539 P62882 407 2.6e-38 Guanine nucleotide-binding protein subunit beta-5 OS=Rattus norvegicus GN=Gnb5 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.56873 BP_3 7.00 0.31 1392 815897760 XP_012249603.1 172 1.0e-09 PREDICTED: gastrula zinc finger protein XlCGF26.1-like [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q7KQZ4 149 2.0e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF04988//PF02892 A-kinase anchoring protein 95 (AKAP95)//BED zinc finger -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.56878 BP_3 59.39 1.01 3135 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56879 BP_3 48.61 0.83 3128 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05834 Lycopene cyclase protein GO:0016117 carotenoid biosynthetic process GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.56885 BP_3 4.64 0.38 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56886 BP_3 1.00 0.44 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56893 BP_3 55.32 0.43 6477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08290 Hepatitis core protein, putative zinc finger GO:0009405 pathogenesis GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.56894 BP_3 19.00 5.96 445 678195957 KFV62939.1 624 1.3e-62 40S ribosomal protein S16, partial [Picoides pubescens] 835909321 XM_004548427.2 143 6.06902e-67 PREDICTED: Maylandia zebra ribosomal protein S16 (rps16), mRNA K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 P62250 619 2.0e-63 40S ribosomal protein S16 OS=Rattus norvegicus GN=Rps16 PE=1 SV=2 PF00380 Ribosomal protein S9/S16 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-8309.56898 BP_3 6.00 0.72 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56899 BP_3 94.54 15.69 582 270008916 EFA05364.1 523 8.6e-51 hypothetical protein TcasGA2_TC015529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain GO:0006213 pyrimidine nucleoside metabolic process GO:0016763 transferase activity, transferring pentosyl groups -- -- -- -- Cluster-8309.56900 BP_3 5.00 0.36 962 808118489 XP_003394580.2 1019 4.3e-108 PREDICTED: LOW QUALITY PROTEIN: vigilin [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q5R439 870 3.4e-92 Vigilin OS=Pongo abelii GN=HDLBP PE=2 SV=1 PF00013//PF13014//PF13184//PF07650 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2208 Vigilin Cluster-8309.56906 BP_3 13.79 0.84 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56915 BP_3 51.65 1.28 2244 270001539 EEZ97986.1 1710 7.5e-188 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 285 3.75647e-145 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 838 4.0e-88 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.56917 BP_3 5.00 1.10 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56918 BP_3 4.00 0.49 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56919 BP_3 13.91 1.11 894 149675194 ABR27684.1 861 8.4e-90 cuticle proprotein proCP3.2 [Callinectes sapidus] 149675193 EF639836.1 376 0 Callinectes sapidus cuticle proprotein proCP3.2 mRNA, complete cds -- -- -- -- P81582 372 1.7e-34 Cuticle protein CP1246 OS=Cancer pagurus PE=1 SV=1 PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.5692 BP_3 18.00 0.55 1862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56920 BP_3 38.79 1.23 1816 642921367 XP_008192837.1 1071 7.6e-114 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K12375 ARSI_J arylsulfatase I/J http://www.genome.jp/dbget-bin/www_bget?ko:K12375 Q5FYB1 305 2.1e-26 Arylsulfatase I OS=Homo sapiens GN=ARSI PE=1 SV=1 PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- KOG3867 Sulfatase Cluster-8309.56923 BP_3 8.00 97.73 238 -- -- -- -- -- 565671674 AB894124.1 40 5.4621e-10 Gryllus bimaculatus DNA, 7SK-like snRNA, 5' region sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56924 BP_3 19.47 0.42 2537 332376342 AEE63311.1 1261 9.9e-136 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01443 nagA, AMDHD2 N-acetylglucosamine-6-phosphate deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K01443 Q9VR81 1121 7.0e-121 Putative N-acetylglucosamine-6-phosphate deacetylase OS=Drosophila melanogaster GN=CG17065 PE=2 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3892 N-acetyl-glucosamine-6-phosphate deacetylase Cluster-8309.56926 BP_3 1387.93 14.32 4963 642918266 XP_008191438.1 5630 0.0e+00 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] 755988817 XM_011313677.1 459 0 PREDICTED: Fopius arisanus dual oxidase (LOC105271872), mRNA K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 5133 0.0e+00 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 PF00036//PF08022//PF08030//PF13202//PF13833//PF13405//PF13499//PF12763 EF hand//FAD-binding domain//Ferric reductase NAD binding domain//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0005509 oxidoreductase activity//protein binding//calcium ion binding -- -- KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.5693 BP_3 26.00 0.40 3404 607360198 EZA54533.1 854 2.1e-88 hypothetical protein X777_05512, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56932 BP_3 71.80 1.50 2602 642928421 XP_008193780.1 2552 2.0e-285 PREDICTED: probable cleavage and polyadenylation specificity factor subunit 2 [Tribolium castaneum]>gi|270010824|gb|EFA07272.1| hypothetical protein TcasGA2_TC014506 [Tribolium castaneum] 665813545 XM_008557111.1 256 5.76794e-129 PREDICTED: Microplitis demolitor probable cleavage and polyadenylation specificity factor subunit 2 (LOC103576746), mRNA K14402 CPSF2, CFT2 cleavage and polyadenylation specificity factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14402 Q9V3D6 2122 6.1e-237 Probable cleavage and polyadenylation specificity factor subunit 2 OS=Drosophila melanogaster GN=Cpsf100 PE=1 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit) Cluster-8309.56934 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56936 BP_3 27.83 0.41 3560 91082383 XP_968748.1 2181 2.9e-242 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1514 2.6e-166 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00931//PF02714//PF00664//PF02367//PF00005//PF03193 NB-ARC domain//Calcium-dependent channel, 7TM region, putative phosphate//ABC transporter transmembrane region//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258 GO:0002949//GO:0006810//GO:0055085 tRNA threonylcarbamoyladenosine modification//transport//transmembrane transport GO:0017111//GO:0042626//GO:0005525//GO:0016887//GO:0043531//GO:0003924//GO:0005524 nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//ADP binding//GTPase activity//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.56937 BP_3 47.62 0.75 3338 546680539 ERL90799.1 851 4.5e-88 hypothetical protein D910_08145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.5694 BP_3 2444.95 128.76 1207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.56940 BP_3 52.47 0.81 3430 478263614 ENN81920.1 2165 2.0e-240 hypothetical protein YQE_01631, partial [Dendroctonus ponderosae] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 776 9.6e-81 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.56941 BP_3 113.55 3.58 1820 91090772 XP_969499.1 1733 1.3e-190 PREDICTED: rapamycin-insensitive companion of mTOR [Tribolium castaneum]>gi|270013969|gb|EFA10417.1| hypothetical protein TcasGA2_TC012657 [Tribolium castaneum] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 827 6.2e-87 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF05933 Fungal ATP synthase protein 8 (A6L) GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG3694 Protein required for meiosis Cluster-8309.56945 BP_3 505.11 7.25 3652 478256893 ENN77062.1 359 5.6e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 5.7e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF01844//PF07975//PF00096//PF13465 HNH endonuclease//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0046872//GO:0003676//GO:0008270//GO:0004519 metal ion binding//nucleic acid binding//zinc ion binding//endonuclease activity -- -- -- -- Cluster-8309.56949 BP_3 159.68 8.28 1221 649572269 NP_001280526.1 494 4.1e-47 arylsulfatase B precursor [Tribolium castaneum]>gi|270008608|gb|EFA05056.1| hypothetical protein TcasGA2_TC015151 [Tribolium castaneum]>gi|521762944|gb|AGQ03798.1| arylsulfatase b [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50430 295 2.0e-25 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF02319//PF00884//PF01232 E2F/DP family winged-helix DNA-binding domain//Sulfatase//Mannitol dehydrogenase Rossmann domain GO:0008152//GO:0006355//GO:0055114 metabolic process//regulation of transcription, DNA-templated//oxidation-reduction process GO:0008484//GO:0003700//GO:0016491 sulfuric ester hydrolase activity//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity GO:0005667 transcription factor complex KOG3867 Sulfatase Cluster-8309.56952 BP_3 288.44 4.29 3531 91083749 XP_971342.1 2204 6.2e-245 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 1121 9.7e-121 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56953 BP_3 463.86 4.80 4948 642914971 XP_008190464.1 1080 1.9e-114 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 2.12693e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 461 4.6e-44 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF05680//PF06703//PF00322//PF01585 ATP synthase E chain//Microsomal signal peptidase 25 kDa subunit (SPC25)//Endothelin family//G-patch domain GO:0019229//GO:0006465//GO:0015986//GO:0015992 regulation of vasoconstriction//signal peptide processing//ATP synthesis coupled proton transport//proton transport GO:0003676//GO:0015078//GO:0008233 nucleic acid binding//hydrogen ion transmembrane transporter activity//peptidase activity GO:0016021//GO:0005576//GO:0000276//GO:0005787 integral component of membrane//extracellular region//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//signal peptidase complex KOG0965 Predicted RNA-binding protein, contains SWAP and G-patch domains Cluster-8309.56957 BP_3 41.19 3.30 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56960 BP_3 33.73 1.08 1801 817203425 XP_012277535.1 2445 3.6e-273 PREDICTED: TFIIH basal transcription factor complex helicase XPD subunit isoform X1 [Orussus abietinus] 572310025 XM_006620723.1 362 0 PREDICTED: Apis dorsata TFIIH basal transcription factor complex helicase XPD subunit-like (LOC102676342), mRNA K10844 ERCC2, XPD DNA excision repair protein ERCC-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10844 O08811 2148 4.1e-240 TFIIH basal transcription factor complex helicase XPD subunit OS=Mus musculus GN=Ercc2 PE=2 SV=2 PF00176//PF06733//PF06777//PF13307 SNF2 family N-terminal domain//DEAD_2//Helical and beta-bridge domain//Helicase C-terminal domain GO:0006139 nucleobase-containing compound metabolic process GO:0004003//GO:0003676//GO:0016818//GO:0005524//GO:0003677//GO:0008026 ATP-dependent DNA helicase activity//nucleic acid binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//DNA binding//ATP-dependent helicase activity GO:0005657//GO:0005634 replication fork//nucleus KOG1131 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 Cluster-8309.56961 BP_3 9.57 0.68 968 642938861 XP_970628.2 422 7.3e-39 PREDICTED: uncharacterized protein LOC659208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56963 BP_3 204.64 7.64 1583 270012124 EFA08572.1 1174 7.6e-126 hypothetical protein TcasGA2_TC006227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI23 400 1.8e-37 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56965 BP_3 96.35 3.20 1742 270012124 EFA08572.1 1174 8.3e-126 hypothetical protein TcasGA2_TC006227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI17 400 1.9e-37 Protein yellow OS=Drosophila yakuba GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56968 BP_3 306.98 6.00 2759 642921884 XP_967663.2 2707 2.3e-303 PREDICTED: conserved oligomeric Golgi complex subunit 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VJD3 1053 5.8e-113 Conserved oligomeric Golgi complex subunit 5 OS=Drosophila melanogaster GN=fws PE=2 SV=1 PF14144//PF10392 Seed dormancy control//Golgi transport complex subunit 5 GO:0006891//GO:0006351 intra-Golgi vesicle-mediated transport//transcription, DNA-templated GO:0043565 sequence-specific DNA binding GO:0017119 Golgi transport complex KOG2211 Predicted Golgi transport complex 1 protein Cluster-8309.5697 BP_3 6.64 0.74 723 642913381 XP_008195471.1 335 6.7e-29 PREDICTED: double-strand-break repair protein rad21 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56971 BP_3 22.00 1.76 893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56974 BP_3 4039.92 87.00 2530 189242412 XP_001810435.1 145 2.5e-06 PREDICTED: glycine-rich cell wall structural protein 1.8 isoform X1 [Tribolium castaneum]>gi|270016263|gb|EFA12709.1| hypothetical protein TcasGA2_TC002343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56976 BP_3 54.07 0.53 5194 808140666 XP_012171915.1 1691 2.8e-185 PREDICTED: transcriptional regulator ATRX homolog [Bombus terrestris] 642928856 XM_008197369.1 131 3.55678e-59 PREDICTED: Tribolium castaneum transcriptional regulator ATRX homolog (LOC657738), transcript variant X2, mRNA K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 Q9GQN5 888 1.5e-93 Transcriptional regulator ATRX homolog OS=Drosophila melanogaster GN=XNP PE=1 SV=2 PF02724//PF04851//PF08361//PF00176 CDC45-like protein//Type III restriction enzyme, res subunit//MAATS-type transcriptional repressor, C-terminal region//SNF2 family N-terminal domain GO:0006270 DNA replication initiation GO:0016787//GO:0003677//GO:0005524 hydrolase activity//DNA binding//ATP binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.56979 BP_3 98.39 0.86 5813 478257774 ENN77917.1 2887 0.0e+00 hypothetical protein YQE_05594, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B2GUN4 1083 4.1e-116 Meiosis arrest female protein 1 homolog OS=Xenopus tropicalis GN=marf1 PE=2 SV=1 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.56981 BP_3 17.00 0.55 1772 91078172 XP_967060.1 365 5.5e-32 PREDICTED: sorting nexin-27 [Tribolium castaneum]>gi|270001364|gb|EEZ97811.1| hypothetical protein TcasGA2_TC000177 [Tribolium castaneum] -- -- -- -- -- K17936 SNX27 sorting nexin-27 http://www.genome.jp/dbget-bin/www_bget?ko:K17936 Q3UHD6 256 9.8e-21 Sorting nexin-27 OS=Mus musculus GN=Snx27 PE=1 SV=2 PF00787 PX domain GO:0007165 signal transduction GO:0035091 phosphatidylinositol binding -- -- -- -- Cluster-8309.56982 BP_3 66.71 1.37 2640 642935245 XP_008197928.1 1903 3.7e-210 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 311 1.55981e-159 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 847 4.3e-89 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05790//PF13895 Immunoglobulin C2-set domain//Immunoglobulin domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.56983 BP_3 13.84 0.80 1124 546684870 ERL94452.1 181 7.5e-11 hypothetical protein D910_11729 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56984 BP_3 9.41 0.74 908 641659246 XP_008181021.1 191 4.2e-12 PREDICTED: uncharacterized protein LOC103308774 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56985 BP_3 39.77 6.89 570 86515366 NP_001034509.1 510 2.7e-49 Sp-like zinc finger transcription factor [Tribolium castaneum]>gi|34979121|gb|AAQ83696.1| Sp-like zinc finger protein [Tribolium castaneum]>gi|270014240|gb|EFA10688.1| lethal Sp8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.56988 BP_3 26.68 0.52 2763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01342 SAND domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.56989 BP_3 5.00 1.01 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56991 BP_3 143.34 6.05 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56997 BP_3 14.13 0.42 1912 328711820 XP_003244649.1 1063 6.8e-113 PREDICTED: uncharacterized protein LOC100569183 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225//PF00628//PF00130 DDE superfamily endonuclease//helix-turn-helix, Psq domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515//GO:0003677//GO:0003676 protein binding//DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.570 BP_3 14.00 0.34 2306 -- -- -- -- -- 462333089 APGK01039098.1 44 3.61379e-11 Dendroctonus ponderosae Seq01039108, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57001 BP_3 41.00 1.80 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.57008 BP_3 6.00 0.62 758 642925502 XP_008194577.1 217 3.4e-15 PREDICTED: immediate early response 3-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CR20 136 3.4e-07 Immediate early response 3-interacting protein 1 OS=Mus musculus GN=Ier3ip1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57010 BP_3 5.07 0.34 1003 332373982 AEE62132.1 182 5.1e-11 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57016 BP_3 23.56 0.39 3233 642926395 XP_970524.2 623 1.2e-61 PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926397|ref|XP_008191945.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926399|ref|XP_008191946.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum] -- -- -- -- -- K07900 RAB9B Ras-related protein Rab-9B http://www.genome.jp/dbget-bin/www_bget?ko:K07900 Q8BHH2 504 3.1e-49 Ras-related protein Rab-9B OS=Mus musculus GN=Rab9b PE=2 SV=1 PF00735//PF08477//PF01926//PF00025//PF03193//PF01637//PF04670//PF00071 Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Protein of unknown function, DUF258//Archaeal ATPase//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity -- -- KOG0394 Ras-related GTPase Cluster-8309.57017 BP_3 3.00 0.84 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57018 BP_3 5.64 0.36 1050 91088325 XP_970263.1 903 1.3e-94 PREDICTED: GTP-binding protein 128up [Tribolium castaneum]>gi|270011791|gb|EFA08239.1| hypothetical protein TcasGA2_TC005867 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P32234 858 9.0e-91 GTP-binding protein 128up OS=Drosophila melanogaster GN=128up PE=2 SV=2 PF01926 50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- KOG1487 GTP-binding protein DRG1 (ODN superfamily) Cluster-8309.5702 BP_3 126.00 2.14 3132 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57020 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57023 BP_3 51.19 1.78 1676 642929319 XP_008195785.1 1361 1.7e-147 PREDICTED: stomatin-like protein 2, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UJZ1 1028 2.8e-110 Stomatin-like protein 2, mitochondrial OS=Homo sapiens GN=STOML2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2620 Prohibitins and stomatins of the PID superfamily Cluster-8309.57029 BP_3 445.16 11.35 2183 642912341 XP_008199603.1 2987 0.0e+00 PREDICTED: DNA polymerase delta catalytic subunit [Tribolium castaneum]>gi|270002921|gb|EEZ99368.1| DNA polymerase delta [Tribolium castaneum] 324120713 AB598708.1 168 4.00461e-80 Euconocephalus varius DPD1 mRNA for DNA polymerase delta catalytic subunit, complete cds, isolate: 7 K02327 POLD1 DNA polymerase delta subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02327 P54358 2376 1.8e-266 DNA polymerase delta catalytic subunit OS=Drosophila melanogaster GN=DNApol-delta PE=2 SV=2 PF03175//PF00136//PF03104 DNA polymerase type B, organellar and viral//DNA polymerase family B//DNA polymerase family B, exonuclease domain GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG0969 DNA polymerase delta, catalytic subunit Cluster-8309.5703 BP_3 29.88 3.23 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57030 BP_3 455.66 5.69 4152 91091528 XP_970224.1 1670 6.1e-183 PREDICTED: myrosinase 1-like [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1130 1.0e-121 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF01491//PF00232//PF00150//PF02926//PF03233 Frataxin-like domain//Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5)//THUMP domain//Aphid transmission protein GO:0019089//GO:0005975//GO:0016226 transmission of virus//carbohydrate metabolic process//iron-sulfur cluster assembly GO:0004553//GO:0003723//GO:0008199 hydrolase activity, hydrolyzing O-glycosyl compounds//RNA binding//ferric iron binding -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.57031 BP_3 41.76 0.47 4548 91091528 XP_970224.1 1670 6.7e-183 PREDICTED: myrosinase 1-like [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1130 1.1e-121 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232//PF00150 Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.57035 BP_3 100.00 1.23 4219 642911057 XP_008200622.1 2095 3.2e-232 PREDICTED: uncharacterized protein LOC655172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6SJE0 191 8.0e-13 GDNF family receptor alpha-like OS=Mus musculus GN=Gfral PE=2 SV=2 PF16093 Proteasome assembly chaperone 4 GO:0043248 proteasome assembly -- -- -- -- -- -- Cluster-8309.57036 BP_3 5.27 0.39 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57037 BP_3 6.00 0.47 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57039 BP_3 204.66 5.67 2032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57040 BP_3 9.85 0.46 1322 -- -- -- -- -- 88605020 DQ386641.1 431 0 Apriona germari transferrin gene, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57045 BP_3 15.64 0.43 2053 478258273 ENN78402.1 400 5.5e-36 hypothetical protein YQE_05202, partial [Dendroctonus ponderosae] -- -- -- -- -- K11498 CENPE centromeric protein E http://www.genome.jp/dbget-bin/www_bget?ko:K11498 Q54G05 213 1.1e-15 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0003777//GO:0005524//GO:0008017 microtubule motor activity//ATP binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG0242 Kinesin-like protein Cluster-8309.57054 BP_3 109.47 1.54 3727 546677436 ERL88273.1 740 3.8e-75 hypothetical protein D910_05660 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.57058 BP_3 67.56 5.26 911 478259929 ENN79731.1 758 7.5e-78 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 440 2.3e-42 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF09243//PF02285 Mitochondrial small ribosomal subunit Rsm22//Cytochrome oxidase c subunit VIII GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.57062 BP_3 2.00 0.33 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57065 BP_3 2.00 3.16 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57070 BP_3 170.98 1.13 7599 642924897 XP_008194088.1 2378 8.9e-265 PREDICTED: laminin subunit alpha-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P24043 786 1.5e-81 Laminin subunit alpha-2 OS=Homo sapiens GN=LAMA2 PE=1 SV=4 PF07544//PF08329//PF00806//PF06009//PF05225//PF04144//PF00424 RNA polymerase II transcription mediator complex subunit 9//Chitinase A, N-terminal domain//Pumilio-family RNA binding repeat//Laminin Domain II//helix-turn-helix, Psq domain//SCAMP family//REV protein (anti-repression trans-activator protein) GO:0006357//GO:0007155//GO:0006355//GO:0006032//GO:0015031//GO:0016998 regulation of transcription from RNA polymerase II promoter//cell adhesion//regulation of transcription, DNA-templated//chitin catabolic process//protein transport//cell wall macromolecule catabolic process GO:0004568//GO:0003700//GO:0003723//GO:0001104//GO:0003677 chitinase activity//transcription factor activity, sequence-specific DNA binding//RNA binding//RNA polymerase II transcription cofactor activity//DNA binding GO:0016592//GO:0016021//GO:0042025//GO:0005667 mediator complex//integral component of membrane//host cell nucleus//transcription factor complex KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.57071 BP_3 162.46 15.53 796 646709824 KDR15513.1 260 3.7e-20 hypothetical protein L798_10579 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q5ZLK8 234 1.6e-18 UPF0669 protein C6orf120 homolog OS=Gallus gallus GN=RCJMB04_5l6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57072 BP_3 37.51 2.66 971 759053515 XP_011335928.1 222 1.1e-15 PREDICTED: DNA repair endonuclease XPF [Cerapachys biroi] -- -- -- -- -- K10848 ERCC4, XPF DNA excision repair protein ERCC-4 http://www.genome.jp/dbget-bin/www_bget?ko:K10848 Q5ZLK8 183 1.6e-12 UPF0669 protein C6orf120 homolog OS=Gallus gallus GN=RCJMB04_5l6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57075 BP_3 27.06 0.84 1845 478264795 ENN82329.1 823 4.4e-85 hypothetical protein YQE_01295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 7.7e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.57076 BP_3 41.46 1.88 1352 546679352 ERL89827.1 823 3.2e-85 hypothetical protein D910_07187 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 5.6e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.57077 BP_3 127.03 4.43 1675 478264795 ENN82329.1 823 4.0e-85 hypothetical protein YQE_01295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 7.0e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.57080 BP_3 1.00 0.68 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08126 Propeptide_C25 GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.57082 BP_3 12.00 0.47 1510 380042040 AFD33363.1 1818 1.5e-200 G protein beta 1 [Scylla paramamosain] 380042039 JQ218936.1 1409 0 Scylla paramamosain G protein beta 1 mRNA, complete cds K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 O45040 1802 4.5e-200 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homarus americanus GN=GBETA1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.57084 BP_3 33.64 1.04 1854 642923410 XP_974378.3 454 2.7e-42 PREDICTED: repressor of RNA polymerase III transcription MAF1 homolog [Tribolium castaneum]>gi|270007640|gb|EFA04088.1| hypothetical protein TcasGA2_TC014322 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PGU2 367 1.4e-33 Repressor of RNA polymerase III transcription MAF1 homolog OS=Danio rerio GN=maf1 PE=2 SV=1 -- -- GO:0016480 negative regulation of transcription from RNA polymerase III promoter -- -- GO:0005634 nucleus KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.57085 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57086 BP_3 255.70 6.64 2149 642938239 XP_008198124.1 1112 1.6e-118 PREDICTED: coiled-coil domain-containing protein 174 [Tribolium castaneum]>gi|270016809|gb|EFA13255.1| hypothetical protein TcasGA2_TC001525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5PQS7 415 4.3e-39 Coiled-coil domain-containing protein 174 OS=Rattus norvegicus GN=Ccdc174 PE=2 SV=2 PF01047 MarR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.57088 BP_3 24.12 0.96 1497 675372920 KFM65822.1 146 1.1e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00236 Glycoprotein hormone GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.57089 BP_3 87.85 1.56 3008 675372920 KFM65822.1 146 2.3e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01429//PF05485//PF03950//PF08782//PF00236 Methyl-CpG binding domain//THAP domain//tRNA synthetases class I (E and Q), anti-codon binding domain//c-SKI Smad4 binding domain//Glycoprotein hormone GO:0007165//GO:0006418 signal transduction//tRNA aminoacylation for protein translation GO:0005524//GO:0003677//GO:0005179//GO:0000166//GO:0003676//GO:0004812//GO:0046332 ATP binding//DNA binding//hormone activity//nucleotide binding//nucleic acid binding//aminoacyl-tRNA ligase activity//SMAD binding GO:0005634//GO:0005576//GO:0005737 nucleus//extracellular region//cytoplasm -- -- Cluster-8309.57093 BP_3 24.07 0.95 1510 675372920 KFM65822.1 140 5.7e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00236 Glycoprotein hormone GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.57095 BP_3 35.46 0.52 3587 675372920 KFM65822.1 146 2.7e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF01429//PF03950//PF08782//PF00619//PF16517 THAP domain//Methyl-CpG binding domain//tRNA synthetases class I (E and Q), anti-codon binding domain//c-SKI Smad4 binding domain//Caspase recruitment domain//Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain GO:0007165//GO:0042981//GO:0006418 signal transduction//regulation of apoptotic process//tRNA aminoacylation for protein translation GO:0003677//GO:0005524//GO:0046332//GO:0004812//GO:0003676//GO:0000166 DNA binding//ATP binding//SMAD binding//aminoacyl-tRNA ligase activity//nucleic acid binding//nucleotide binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.57100 BP_3 5.00 0.75 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57101 BP_3 7.00 0.70 774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57103 BP_3 37.20 0.36 5319 91080947 XP_974375.1 1989 8.0e-220 PREDICTED: protein arginine N-methyltransferase 1 [Tribolium castaneum]>gi|270005950|gb|EFA02398.1| hypothetical protein TcasGA2_TC008078 [Tribolium castaneum] -- -- -- -- -- K11436 PRMT3 protein arginine N-methyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11436 O60678 1062 1.0e-113 Protein arginine N-methyltransferase 3 OS=Homo sapiens GN=PRMT3 PE=1 SV=3 PF05185//PF01209//PF01340//PF03602//PF00517//PF02140//PF02390//PF01728//PF08241//PF05175//PF01135 PRMT5 arginine-N-methyltransferase//ubiE/COQ5 methyltransferase family//Met Apo-repressor, MetJ//Conserved hypothetical protein 95//Retroviral envelope protein//Galactose binding lectin domain//Putative methyltransferase//FtsJ-like methyltransferase//Methyltransferase domain//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006355//GO:0008033//GO:0006464//GO:0031167//GO:0009451//GO:0006479//GO:0046500//GO:0006555//GO:0006400//GO:0032259//GO:0008152 regulation of transcription, DNA-templated//tRNA processing//cellular protein modification process//rRNA methylation//RNA modification//protein methylation//S-adenosylmethionine metabolic process//methionine metabolic process//tRNA modification//methylation//metabolic process GO:0030246//GO:0008168//GO:0003700//GO:0005198//GO:0008176//GO:0004719 carbohydrate binding//methyltransferase activity//transcription factor activity, sequence-specific DNA binding//structural molecule activity//tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0019031//GO:0005667 viral envelope//transcription factor complex KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.57106 BP_3 25.08 0.89 1650 642925861 XP_008190588.1 1004 4.1e-106 PREDICTED: osmotic avoidance abnormal protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P46873 372 3.2e-34 Osmotic avoidance abnormal protein 3 OS=Caenorhabditis elegans GN=osm-3 PE=2 SV=4 PF01618 MotA/TolQ/ExbB proton channel family GO:0006810//GO:0015031 transport//protein transport GO:0008565 protein transporter activity GO:0016020 membrane KOG4280 Kinesin-like protein Cluster-8309.57108 BP_3 179.99 17.04 801 478255797 ENN76005.1 479 1.5e-45 hypothetical protein YQE_07385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T635 326 3.4e-29 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF15761//PF00379 Immortalisation up-regulated protein//Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle GO:0005634 nucleus -- -- Cluster-8309.57109 BP_3 74.90 3.20 1421 91078956 XP_974192.1 719 3.9e-73 PREDICTED: protein prune homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BIW1 423 3.4e-40 Protein prune homolog OS=Mus musculus GN=Prune PE=2 SV=1 PF02833 DHHA2 domain -- -- GO:0016462 pyrophosphatase activity GO:0005737 cytoplasm KOG4129 Exopolyphosphatases and related proteins Cluster-8309.57113 BP_3 50.13 1.31 2140 125979697 XP_001353881.1 237 4.6e-17 GA19831 [Drosophila pseudoobscura pseudoobscura]>gi|54640865|gb|EAL29616.1| GA19831 [Drosophila pseudoobscura pseudoobscura] -- -- -- -- -- -- -- -- -- O55226 173 5.0e-11 Chondroadherin OS=Mus musculus GN=Chad PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.57118 BP_3 1.00 0.42 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57119 BP_3 3.00 0.82 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57120 BP_3 19.86 0.42 2570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57122 BP_3 17.96 0.40 2464 546683161 ERL93009.1 786 1.2e-80 hypothetical protein D910_10311 [Dendroctonus ponderosae] -- -- -- -- -- K04729 MYD88 myeloid differentiation primary response protein MyD88 http://www.genome.jp/dbget-bin/www_bget?ko:K04729 A8QMS7 266 9.4e-22 Myeloid differentiation primary response protein MyD88 OS=Takifugu rubripes GN=myd88 PE=2 SV=1 PF13676//PF01582//PF00531 TIR domain//TIR domain//Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.57123 BP_3 38.85 0.56 3617 546683161 ERL93009.1 902 6.0e-94 hypothetical protein D910_10311 [Dendroctonus ponderosae] -- -- -- -- -- K04729 MYD88 myeloid differentiation primary response protein MyD88 http://www.genome.jp/dbget-bin/www_bget?ko:K04729 A8QMS7 316 2.2e-27 Myeloid differentiation primary response protein MyD88 OS=Takifugu rubripes GN=myd88 PE=2 SV=1 PF00531//PF13676//PF01582 Death domain//TIR domain//TIR domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.57127 BP_3 21.36 0.31 3615 642928611 XP_008199978.1 2290 6.8e-255 PREDICTED: FERM domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UFK8 547 3.6e-54 FERM domain-containing protein 8 OS=Mus musculus GN=Frmd8 PE=1 SV=2 PF04218//PF01527 CENP-B N-terminal DNA-binding domain//Transposase GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- KOG4335 FERM domain-containing protein KRIT1 Cluster-8309.57128 BP_3 69.00 7.78 719 478253867 ENN74159.1 296 2.2e-24 hypothetical protein YQE_09132, partial [Dendroctonus ponderosae]>gi|546684676|gb|ERL94293.1| hypothetical protein D910_11574 [Dendroctonus ponderosae] -- -- -- -- -- K17779 TIM10B mitochondrial import inner membrane translocase subunit TIM10B http://www.genome.jp/dbget-bin/www_bget?ko:K17779 Q568N4 217 1.3e-16 Mitochondrial import inner membrane translocase subunit Tim10 B OS=Danio rerio GN=timm10b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3479 Mitochondrial import inner membrane translocase, subunit TIM9 Cluster-8309.57129 BP_3 642.98 7.09 4664 189237968 XP_001811946.1 3393 0.0e+00 PREDICTED: TBC1 domain family member 25 isoform X1 [Tribolium castaneum]>gi|270008039|gb|EFA04487.1| hypothetical protein TcasGA2_TC014792 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MII6 1090 5.0e-117 TBC1 domain family member 25 OS=Homo sapiens GN=TBC1D25 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.5713 BP_3 32.07 0.64 2713 642932300 XP_008197055.1 454 4.0e-42 PREDICTED: protein UXT isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7T0W1 170 1.4e-10 Protein UXT homolog OS=Nematostella vectensis GN=v1g140887 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57133 BP_3 312.00 5.48 3034 546684589 ERL94206.1 2029 1.0e-224 hypothetical protein D910_11487, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5VU97 1138 8.9e-123 VWFA and cache domain-containing protein 1 OS=Homo sapiens GN=CACHD1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57136 BP_3 29.35 0.51 3043 546678946 ERL89484.1 1688 3.6e-185 hypothetical protein D910_06850 [Dendroctonus ponderosae] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 Q9W1H4 1421 1.4e-155 DNA ligase 1 OS=Drosophila melanogaster GN=DNA-ligI PE=1 SV=2 PF01068//PF04838//PF01331//PF04679 ATP dependent DNA ligase domain//Baculoviridae late expression factor 5//mRNA capping enzyme, catalytic domain//ATP dependent DNA ligase C terminal region GO:0006355//GO:0006370//GO:0006310//GO:0006260//GO:0006281//GO:0006397 regulation of transcription, DNA-templated//7-methylguanosine mRNA capping//DNA recombination//DNA replication//DNA repair//mRNA processing GO:0003910//GO:0004484//GO:0005524 DNA ligase (ATP) activity//mRNA guanylyltransferase activity//ATP binding -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.57139 BP_3 31.00 0.36 4442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05313 Poxvirus P21 membrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.57142 BP_3 37.09 0.43 4470 562874119 XP_006164934.1 407 1.9e-36 PREDICTED: zinc finger protein 717-like [Tupaia chinensis] 642932060 XM_008198621.1 176 2.95127e-84 PREDICTED: Tribolium castaneum protein lin-54 homolog (LOC663835), transcript variant X3, mRNA -- -- -- -- Q6P560 403 2.2e-37 Zinc finger protein 182 OS=Mus musculus GN=Znf182 PE=2 SV=1 PF13912//PF00412//PF16622//PF00320//PF01428//PF13465//PF07975//PF01780//PF00096 C2H2-type zinc finger//LIM domain//zinc-finger C2H2-type//GATA zinc finger//AN1-like Zinc finger//Zinc-finger double domain//TFIIH C1-like domain//Ribosomal L37ae protein family//Zinc finger, C2H2 type GO:0042254//GO:0006355//GO:0006281//GO:0006412 ribosome biogenesis//regulation of transcription, DNA-templated//DNA repair//translation GO:0003700//GO:0046872//GO:0008270//GO:0043565//GO:0003735 transcription factor activity, sequence-specific DNA binding//metal ion binding//zinc ion binding//sequence-specific DNA binding//structural constituent of ribosome GO:0005840//GO:0005622//GO:0005667 ribosome//intracellular//transcription factor complex -- -- Cluster-8309.57144 BP_3 235.48 2.76 4402 444518819 ELV12406.1 411 6.3e-37 Zinc finger protein 717 [Tupaia chinensis] 642932060 XM_008198621.1 176 2.90601e-84 PREDICTED: Tribolium castaneum protein lin-54 homolog (LOC663835), transcript variant X3, mRNA -- -- -- -- Q6P560 406 9.8e-38 Zinc finger protein 182 OS=Mus musculus GN=Znf182 PE=2 SV=1 PF07975//PF13465//PF00096//PF01428//PF16622//PF00412//PF13912 TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type//AN1-like Zinc finger//zinc-finger C2H2-type//LIM domain//C2H2-type zinc finger GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.57148 BP_3 2.00 0.55 467 646703926 KDR12352.1 416 1.7e-38 Pikachurin, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q4VBE4 219 5.0e-17 Pikachurin OS=Mus musculus GN=Egflam PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57149 BP_3 5.62 0.32 1136 546680621 ERL90859.1 910 2.2e-95 hypothetical protein D910_08204, partial [Dendroctonus ponderosae] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P15848 421 4.6e-40 Arylsulfatase B OS=Homo sapiens GN=ARSB PE=1 SV=1 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.57150 BP_3 56.00 1.72 1861 602643062 XP_007444770.1 578 1.1e-56 PREDICTED: zinc finger protein 91-like, partial [Python bivittatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9HCG1 548 1.4e-54 Zinc finger protein 160 OS=Homo sapiens GN=ZNF160 PE=2 SV=3 PF13465//PF00096//PF13912//PF02892//PF07776//PF16622//PF06467 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.57152 BP_3 21.96 0.31 3653 642923250 XP_008193676.1 4383 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 66 3.3902e-23 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 1810 1.3e-200 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF00569//PF06701//PF07649//PF13606//PF00097//PF00023 Zinc finger, ZZ type//Mib_herc2//C1-like domain//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat GO:0055114//GO:0016567 oxidation-reduction process//protein ubiquitination GO:0008270//GO:0004842//GO:0047134//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//protein-disulfide reductase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.57153 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57154 BP_3 75.16 1.49 2727 270006862 EFA03310.1 266 2.5e-20 hypothetical protein TcasGA2_TC013252 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q9CZV8 145 1.1e-07 F-box/LRR-repeat protein 20 OS=Mus musculus GN=Fbxl20 PE=1 SV=3 PF12937//PF15966//PF00646 F-box-like//F-box//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57160 BP_3 10.09 0.47 1318 478254560 ENN74803.1 714 1.4e-72 hypothetical protein YQE_08576, partial [Dendroctonus ponderosae]>gi|546681652|gb|ERL91703.1| hypothetical protein D910_09030 [Dendroctonus ponderosae] -- -- -- -- -- K19219 JMJD7 jumonji domain-containing protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K19219 P0C872 467 2.5e-45 JmjC domain-containing protein 7 OS=Mus musculus GN=Jmjd7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.57162 BP_3 59.54 0.81 3814 642915022 XP_008190487.1 3467 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] 642915021 XM_008192265.1 576 0 PREDICTED: Tribolium castaneum cubilin (LOC662433), mRNA -- -- -- -- Q9JLB4 416 5.9e-39 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF05393//PF02480//PF00057//PF15681 Human adenovirus early E3A glycoprotein//Alphaherpesvirus glycoprotein E//Low-density lipoprotein receptor domain class A//Lymphocyte activation family X GO:0051249//GO:0006955 regulation of lymphocyte activation//immune response GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.57164 BP_3 583.98 8.22 3714 642911182 XP_008200615.1 3048 0.0e+00 PREDICTED: WD repeat-containing protein 35 [Tribolium castaneum] 780035245 XM_778124.4 37 4.55512e-07 PREDICTED: Strongylocentrotus purpuratus WD repeat-containing protein 35 (LOC577925), transcript variant X3, mRNA -- -- -- -- A6N6J5 1734 8.5e-192 WD repeat-containing protein 35 OS=Rattus norvegicus GN=Wdr35 PE=1 SV=1 PF13181//PF04053//PF00637//PF13176 Tetratricopeptide repeat//Coatomer WD associated region//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG2503 Tubby superfamily protein TULP4 Cluster-8309.57166 BP_3 1.00 0.57 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.57168 BP_3 101.51 6.68 1024 642927610 XP_008195334.1 722 1.3e-73 PREDICTED: conserved oligomeric Golgi complex subunit 1 [Tribolium castaneum]>gi|270011053|gb|EFA07501.1| pebbled [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGC3 246 8.1e-20 Conserved oligomeric Golgi complex subunit 1 OS=Drosophila melanogaster GN=CG4848 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57172 BP_3 40.15 3.27 884 665790563 XP_008560974.1 184 2.6e-11 PREDICTED: pro-resilin [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57173 BP_3 46.86 0.85 2957 641659262 XP_008181029.1 548 5.5e-53 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- O96006 210 3.5e-15 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 PF05699//PF02892 hAT family C-terminal dimerisation region//BED zinc finger -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- KOG1121 Tam3-transposase (Ac family) Cluster-8309.57174 BP_3 172.00 8.99 1214 674304042 AIL23552.1 749 1.1e-76 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q01579 427 9.9e-41 Glutathione S-transferase theta-1 OS=Rattus norvegicus GN=Gstt1 PE=1 SV=2 PF02798//PF13417//PF04061//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//ORMDL family//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG0867 Glutathione S-transferase Cluster-8309.57176 BP_3 867.04 3.32 12896 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 800 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.3e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF06743//PF01017//PF03124//PF01436//PF14634//PF00643//PF00097 FAST kinase-like protein, subdomain 1//STAT protein, all-alpha domain//EXS family//NHL repeat//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003700//GO:0046872//GO:0004672//GO:0008270//GO:0004871//GO:0005515 transcription factor activity, sequence-specific DNA binding//metal ion binding//protein kinase activity//zinc ion binding//signal transducer activity//protein binding GO:0005622//GO:0005667//GO:0016021 intracellular//transcription factor complex//integral component of membrane KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.57177 BP_3 17.37 4.20 491 642917716 XP_008191343.1 233 3.1e-17 PREDICTED: ecotropic viral integration site 5 ortholog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57179 BP_3 11.00 2.77 483 546676696 ERL87652.1 327 3.8e-28 hypothetical protein D910_05043 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W0K7 145 2.0e-08 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57180 BP_3 3.50 0.33 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57181 BP_3 22.19 1.37 1074 270012943 EFA09391.1 534 8.4e-52 hypothetical protein TcasGA2_TC004309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57183 BP_3 10.20 0.43 1427 270007165 EFA03613.1 196 1.7e-12 hypothetical protein TcasGA2_TC013701 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57184 BP_3 25.00 1.52 1087 321466115 EFX77112.1 1058 1.5e-112 hypothetical protein DAPPUDRAFT_231133 [Daphnia pulex] 307352166 HM143923.2 606 0 Eriocheir sinensis voltage-dependent anion-selective channel mRNA, complete cds K15040 VDAC2 voltage-dependent anion channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15040 P82013 946 5.9e-101 Voltage-dependent anion-selective channel protein 2 OS=Meleagris gallopavo GN=VDAC2 PE=1 SV=1 PF01459 Eukaryotic porin GO:0055085 transmembrane transport -- -- GO:0005741 mitochondrial outer membrane KOG3126 Porin/voltage-dependent anion-selective channel protein Cluster-8309.57185 BP_3 13.24 0.35 2099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.57188 BP_3 69.65 0.51 6920 642935081 XP_008197876.1 3574 0.0e+00 PREDICTED: calmodulin-binding transcription activator 2-like isoform X2 [Tribolium castaneum] 642935084 XM_008199656.1 481 0 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- Q9Y6Y1 557 4.8e-55 Calmodulin-binding transcription activator 1 OS=Homo sapiens GN=CAMTA1 PE=1 SV=4 PF13606//PF01833//PF00612//PF00023 Ankyrin repeat//IPT/TIG domain//IQ calmodulin-binding motif//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0520 Uncharacterized conserved protein, contains IPT/TIG domain Cluster-8309.5719 BP_3 5.91 0.82 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57190 BP_3 16.88 0.44 2136 642933410 XP_008197405.1 1792 2.2e-197 PREDICTED: sodium-independent sulfate anion transporter isoform X2 [Tribolium castaneum] 672070250 XM_006247940.2 44 3.34327e-11 PREDICTED: Rattus norvegicus solute carrier family 26 (anion exchanger), member 11 (Slc26a11), transcript variant X4, mRNA K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 882 3.0e-93 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.57192 BP_3 28.00 1.29 1338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57196 BP_3 4.00 0.61 606 270007962 EFA04410.1 671 6.1e-68 hypothetical protein TcasGA2_TC014710 [Tribolium castaneum] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8WXX0 636 2.9e-65 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 PF03028//PF10589 Dynein heavy chain and region D6 of dynein motor//NADH-ubiquinone oxidoreductase-F iron-sulfur binding region GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0051539//GO:0003777 4 iron, 4 sulfur cluster binding//microtubule motor activity GO:0030286//GO:0005874 dynein complex//microtubule -- -- Cluster-8309.57200 BP_3 70.32 2.79 1506 642932300 XP_008197055.1 454 2.2e-42 PREDICTED: protein UXT isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7T0W1 170 7.8e-11 Protein UXT homolog OS=Nematostella vectensis GN=v1g140887 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57202 BP_3 22.04 0.43 2752 642935230 XP_008199701.1 715 2.2e-72 PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum]>gi|642935232|ref|XP_008199702.1| PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4JL91 194 2.4e-13 Inositol-pentakisphosphate 2-kinase OS=Danio rerio GN=ippk PE=1 SV=3 PF06090//PF11857 Inositol-pentakisphosphate 2-kinase//Domain of unknown function (DUF3377) -- -- GO:0005524//GO:0004222//GO:0035299 ATP binding//metalloendopeptidase activity//inositol pentakisphosphate 2-kinase activity -- -- -- -- Cluster-8309.57208 BP_3 93.10 4.57 1274 642938702 XP_001809371.2 733 8.3e-75 PREDICTED: PWWP domain-containing protein 2A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57211 BP_3 138.46 1.00 6945 642916413 XP_008191014.1 2582 1.8e-288 PREDICTED: uncharacterized protein LOC664255 isoform X4 [Tribolium castaneum] -- -- -- -- -- K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 744 9.9e-77 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF00595//PF13180//PF02198//PF00536//PF08040//PF07647 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//MNLL subunit//SAM domain (Sterile alpha motif) GO:0006118 obsolete electron transport GO:0005515//GO:0003954//GO:0043565 protein binding//NADH dehydrogenase activity//sequence-specific DNA binding GO:0005739//GO:0005634 mitochondrion//nucleus KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.57212 BP_3 796.15 5.76 6957 270003642 EFA00090.1 2579 4.0e-288 hypothetical protein TcasGA2_TC002905 [Tribolium castaneum] 642916410 XM_008192791.1 112 1.74015e-48 PREDICTED: Tribolium castaneum uncharacterized LOC664255 (LOC664255), transcript variant X3, mRNA K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 744 9.9e-77 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF08040//PF07647//PF00536//PF13180//PF02198//PF00595 MNLL subunit//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PDZ domain//Sterile alpha motif (SAM)/Pointed domain//PDZ domain (Also known as DHR or GLGF) GO:0006118 obsolete electron transport GO:0043565//GO:0005515//GO:0003954 sequence-specific DNA binding//protein binding//NADH dehydrogenase activity GO:0005634//GO:0005739 nucleus//mitochondrion KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.57213 BP_3 16.46 0.50 1884 478260118 ENN79903.1 999 1.8e-105 hypothetical protein YQE_03722, partial [Dendroctonus ponderosae]>gi|546679501|gb|ERL89960.1| hypothetical protein D910_07319 [Dendroctonus ponderosae] -- -- -- -- -- K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 179 8.8e-12 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF00771//PF10473 FHIPEP family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0009306 protein secretion GO:0008134//GO:0045502//GO:0042803 transcription factor binding//dynein binding//protein homodimerization activity GO:0005667//GO:0016020//GO:0030286 transcription factor complex//membrane//dynein complex KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.57216 BP_3 97.04 0.74 6605 270003642 EFA00090.1 2560 6.1e-286 hypothetical protein TcasGA2_TC002905 [Tribolium castaneum] 642916410 XM_008192791.1 112 1.65164e-48 PREDICTED: Tribolium castaneum uncharacterized LOC664255 (LOC664255), transcript variant X3, mRNA K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 744 9.4e-77 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF08040//PF07647//PF00536//PF13180//PF02198//PF00595 MNLL subunit//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PDZ domain//Sterile alpha motif (SAM)/Pointed domain//PDZ domain (Also known as DHR or GLGF) GO:0006118 obsolete electron transport GO:0043565//GO:0003954//GO:0005515 sequence-specific DNA binding//NADH dehydrogenase activity//protein binding GO:0005634//GO:0005739 nucleus//mitochondrion KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.57218 BP_3 53.35 0.38 6982 270003642 EFA00090.1 2560 6.4e-286 hypothetical protein TcasGA2_TC002905 [Tribolium castaneum] 642916410 XM_008192791.1 112 1.74644e-48 PREDICTED: Tribolium castaneum uncharacterized LOC664255 (LOC664255), transcript variant X3, mRNA K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 744 1.0e-76 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF02198//PF13180//PF00595//PF08040//PF07647//PF00536 Sterile alpha motif (SAM)/Pointed domain//PDZ domain//PDZ domain (Also known as DHR or GLGF)//MNLL subunit//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0006118 obsolete electron transport GO:0043565//GO:0005515//GO:0003954 sequence-specific DNA binding//protein binding//NADH dehydrogenase activity GO:0005634//GO:0005739 nucleus//mitochondrion KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.57219 BP_3 56.55 0.62 4701 642923667 XP_008193834.1 3787 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2218 8.1e-248 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF03205//PF06414//PF00006//PF02367//PF00005//PF03193//PF03266//PF00931//PF00664//PF01443//PF13304//PF01926//PF08477//PF00437//PF05136 Molybdopterin guanine dinucleotide synthesis protein B//Zeta toxin//ATP synthase alpha/beta family, nucleotide-binding domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258//NTPase//NB-ARC domain//ABC transporter transmembrane region//Viral (Superfamily 1) RNA helicase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Type II/IV secretion system protein//Phage portal protein, lambda family GO:0002949//GO:0007264//GO:0055085//GO:0006810//GO:0006777//GO:0019068 tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction//transmembrane transport//transport//Mo-molybdopterin cofactor biosynthetic process//virion assembly GO:0043531//GO:0005525//GO:0098519//GO:0005524//GO:0003924//GO:0005198//GO:0016301//GO:0016887//GO:0042626 ADP binding//GTP binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//GTPase activity//structural molecule activity//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.57220 BP_3 6.89 0.41 1097 345497989 XP_001603263.2 304 4.0e-25 PREDICTED: multidrug resistance-associated protein 4-like [Nasonia vitripennis] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 183 1.8e-12 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.57222 BP_3 16.46 0.49 1918 91077266 XP_974141.1 821 7.9e-85 PREDICTED: trypsin-1 [Tribolium castaneum]>gi|270002819|gb|EEZ99266.1| serine protease P22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBI0 309 7.6e-27 Transmembrane protease serine 6 OS=Mus musculus GN=Tmprss6 PE=1 SV=4 PF00089//PF02679 Trypsin//(2R)-phospho-3-sulfolactate synthase (ComA) GO:0006508//GO:0019295 proteolysis//coenzyme M biosynthetic process GO:0004252//GO:0008236 serine-type endopeptidase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.57224 BP_3 2.00 0.32 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57225 BP_3 84.91 4.70 1162 478257455 ENN77611.1 137 9.8e-06 hypothetical protein YQE_05906, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57228 BP_3 202.85 2.10 4945 642927107 XP_008195140.1 3464 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Tribolium castaneum] 642927106 XM_008196918.1 476 0 PREDICTED: Tribolium castaneum sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (LOC660611), mRNA -- -- -- -- Q22328 982 1.8e-104 Protein lev-9 OS=Caenorhabditis elegans GN=lev-9 PE=1 SV=3 PF02793//PF00095 Hormone receptor domain//WAP-type (Whey Acidic Protein) 'four-disulfide core' GO:0007186 G-protein coupled receptor signaling pathway GO:0030414//GO:0004930 peptidase inhibitor activity//G-protein coupled receptor activity GO:0016020//GO:0005576 membrane//extracellular region KOG4297 C-type lectin Cluster-8309.57229 BP_3 123.00 1.98 3280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57235 BP_3 33.29 1.27 1554 91084853 XP_967519.1 230 2.2e-16 PREDICTED: uncharacterized protein LOC655864 [Tribolium castaneum]>gi|270008971|gb|EFA05419.1| hypothetical protein TcasGA2_TC015595 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57236 BP_3 274.12 2.43 5732 189236323 XP_975243.2 2714 7.3e-304 PREDICTED: condensin complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YHY6 1375 5.6e-150 Condensin complex subunit 1 OS=Xenopus laevis GN=ncapd2 PE=1 SV=1 PF02985//PF05434//PF04888 HEAT repeat//TMEM9//Secretion system effector C (SseC) like family GO:0009405 pathogenesis GO:0005515 protein binding GO:0016021 integral component of membrane KOG0414 Chromosome condensation complex Condensin, subunit D2 Cluster-8309.57244 BP_3 421.22 5.61 3910 642914878 XP_008190428.1 3797 0.0e+00 PREDICTED: unconventional myosin-Ia [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 P10568 1414 1.1e-154 Unconventional myosin-Ia OS=Bos taurus GN=MYO1A PE=2 SV=1 PF00437//PF06017//PF00612//PF06414//PF00063 Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Zeta toxin//Myosin head (motor domain) GO:0006810 transport GO:0005515//GO:0016301//GO:0003774//GO:0005524 protein binding//kinase activity//motor activity//ATP binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.57246 BP_3 70.68 1.05 3536 91089927 XP_973012.1 172 2.6e-09 PREDICTED: uncharacterized protein LOC661778 [Tribolium castaneum]>gi|270013560|gb|EFA10008.1| hypothetical protein TcasGA2_TC012178 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08513 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57247 BP_3 10.09 1.43 631 642918082 XP_008193932.1 859 1.0e-89 PREDICTED: protein disulfide-isomerase TMX3 [Tribolium castaneum] 847138403 XM_002939615.3 35 9.57037e-07 PREDICTED: Xenopus (Silurana) tropicalis thioredoxin-related transmembrane protein 3 (tmx3), mRNA K09585 TXNDC10 thioredoxin domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09585 Q6GNG3 429 3.0e-41 Protein disulfide-isomerase TMX3 OS=Xenopus laevis GN=tmx3 PE=2 SV=1 PF01216//PF00659//PF00085 Calsequestrin//POLO box duplicated region//Thioredoxin GO:0045454 cell redox homeostasis GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.57248 BP_3 30.00 0.60 2709 662196978 XP_008471543.1 217 1.2e-14 PREDICTED: innexin inx1 [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q9XYN0 207 7.2e-15 Innexin inx1 OS=Schistocerca americana GN=inx1 PE=1 SV=1 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.57251 BP_3 6454.81 446.20 989 270012485 EFA08933.1 488 1.7e-46 hypothetical protein TcasGA2_TC006640 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57253 BP_3 40.74 0.90 2474 642938493 XP_008198006.1 1723 2.6e-189 PREDICTED: nose resistant to fluoxetine protein 6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 478 2.5e-46 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF07694 Acyltransferase family//5TMR of 5TMR-LYT GO:0000160//GO:0016310//GO:0071555 phosphorelay signal transduction system//phosphorylation//cell wall organization GO:0000155//GO:0004673//GO:0016747 phosphorelay sensor kinase activity//protein histidine kinase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex -- -- Cluster-8309.57254 BP_3 17.82 0.72 1478 642927554 XP_008195313.1 861 1.4e-89 PREDICTED: UPF0505 protein C16orf62 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VHM2 497 9.2e-49 UPF0505 protein CG8202 OS=Drosophila melanogaster GN=CG8202 PE=2 SV=3 PF03635 Vacuolar protein sorting-associated protein 35 GO:0015031//GO:0042147 protein transport//retrograde transport, endosome to Golgi GO:0008565 protein transporter activity GO:0030904 retromer complex KOG3682 Predicted membrane protein (associated with esophageal cancer in humans) Cluster-8309.57256 BP_3 4.01 0.57 634 546682907 ERL92786.1 233 3.9e-17 hypothetical protein D910_10094 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12763//PF13202//PF13499//PF00036//PF13833//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.57259 BP_3 2.00 1.37 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57262 BP_3 154.88 6.41 1457 751227278 XP_011167114.1 352 1.4e-30 PREDICTED: uncharacterized protein LOC105200996 isoform X1 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.57266 BP_3 126.70 1.62 4062 642910790 XP_008193412.1 598 1.2e-58 PREDICTED: COMM domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQ02 306 3.6e-26 COMM domain-containing protein 4 OS=Mus musculus GN=Commd4 PE=2 SV=1 PF10538//PF05434 Immunoreceptor tyrosine-based activation motif//TMEM9 GO:0007165 signal transduction -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.57267 BP_3 57.97 1.58 2059 -- -- -- -- -- 642918204 XM_008193188.1 112 5.09289e-49 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF06203 CCT motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57271 BP_3 18.02 0.65 1628 478249784 ENN70291.1 1109 2.7e-118 hypothetical protein YQE_12803, partial [Dendroctonus ponderosae] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 797 1.7e-83 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF00209//PF04505 Sodium:neurotransmitter symporter family//Interferon-induced transmembrane protein GO:0006812//GO:0006836//GO:0009607 cation transport//neurotransmitter transport//response to biotic stimulus GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3660 Sodium-neurotransmitter symporter Cluster-8309.57272 BP_3 18.42 0.42 2392 642913239 XP_008201452.1 744 8.3e-76 PREDICTED: WD repeat-containing protein 61 [Tribolium castaneum]>gi|270001971|gb|EEZ98418.1| hypothetical protein TcasGA2_TC000886 [Tribolium castaneum] -- -- -- -- -- K12602 WDR61, REC14, SKI8 WD repeat-containing protein 61 http://www.genome.jp/dbget-bin/www_bget?ko:K12602 Q9GZS3 602 1.0e-60 WD repeat-containing protein 61 OS=Homo sapiens GN=WDR61 PE=1 SV=1 PF00400//PF04053 WD domain, G-beta repeat//Coatomer WD associated region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG4155 FOG: WD40 repeat Cluster-8309.57275 BP_3 45.00 4.87 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57276 BP_3 30.55 1.15 1577 189240403 XP_001809051.1 773 2.4e-79 PREDICTED: sialin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q8BN82 353 4.9e-32 Sialin OS=Mus musculus GN=Slc17a5 PE=1 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.57281 BP_3 145.55 3.47 2313 91087271 XP_975540.1 2035 1.6e-225 PREDICTED: TLD domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJX5 624 2.7e-63 TLD domain-containing protein 1 OS=Gallus gallus GN=TLDC1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2557 Uncharacterized conserved protein, contains TLDc domain Cluster-8309.57282 BP_3 236.27 4.89 2619 91090272 XP_970617.1 2325 4.3e-259 PREDICTED: nitrogen permease regulator 3-like protein [Tribolium castaneum]>gi|270013442|gb|EFA09890.1| hypothetical protein TcasGA2_TC012039 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUB4 1321 4.6e-144 Nitrogen permease regulator 3-like protein OS=Drosophila melanogaster GN=CG8783 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3830 Uncharacterized conserved protein Cluster-8309.57283 BP_3 228.73 2.50 4694 270014457 EFA10905.1 248 5.3e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.57284 BP_3 223.09 2.24 5082 270014457 EFA10905.1 248 5.8e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.57285 BP_3 38.18 0.44 4430 270014457 EFA10905.1 248 5.0e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF00628//PF16588 Zinc knuckle//PHD-finger//C2H2 zinc-finger -- -- GO:0008270//GO:0003676//GO:0005515 zinc ion binding//nucleic acid binding//protein binding -- -- -- -- Cluster-8309.57286 BP_3 103.43 1.59 3434 91078076 XP_971952.1 1434 1.2e-155 PREDICTED: probable proline--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01881 PARS, proS prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01881 Q7L3T8 998 1.7e-106 Probable proline--tRNA ligase, mitochondrial OS=Homo sapiens GN=PARS2 PE=1 SV=1 PF01155//PF00587//PF14895 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//tRNA synthetase class II core domain (G, H, P, S and T)//Protein phosphatase 1 inhibitor GO:0006418//GO:0006464//GO:0010923 tRNA aminoacylation for protein translation//cellular protein modification process//negative regulation of phosphatase activity GO:0000166//GO:0019902//GO:0004812//GO:0005524//GO:0016151 nucleotide binding//phosphatase binding//aminoacyl-tRNA ligase activity//ATP binding//nickel cation binding -- -- KOG2324 Prolyl-tRNA synthetase Cluster-8309.57287 BP_3 163.72 1.58 5282 2072951 AAC51263.1 199 2.9e-12 putative p150 [Homo sapiens] 18042322 AC074239.5 38 1.80642e-07 Homo sapiens BAC clone CTD-2011N5 from 2, complete sequence -- -- -- -- O00370 194 4.5e-13 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57289 BP_3 44.36 0.87 2755 642935255 XP_008197934.1 1688 3.3e-185 PREDICTED: coiled-coil domain-containing protein 142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04437 RINT-1 / TIP-1 family GO:0048193 Golgi vesicle transport -- -- GO:0005783 endoplasmic reticulum -- -- Cluster-8309.57292 BP_3 190.96 2.21 4463 642928750 XP_008199767.1 2943 0.0e+00 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] 642928749 XM_008201545.1 658 0 PREDICTED: Tribolium castaneum uncharacterized LOC663132 (LOC663132), mRNA -- -- -- -- O60500 211 4.1e-15 Nephrin OS=Homo sapiens GN=NPHS1 PE=1 SV=1 PF05808//PF00001//PF13895 Podoplanin//7 transmembrane receptor (rhodopsin family)//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.57293 BP_3 91.00 2.39 2127 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01191 RNA polymerase Rpb5, C-terminal domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.57295 BP_3 164.00 5.67 1687 642939169 XP_008200363.1 1187 2.5e-127 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum] -- -- -- -- -- K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8BJA2 646 5.6e-66 Solute carrier family 41 member 1 OS=Mus musculus GN=Slc41a1 PE=2 SV=1 PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- KOG3788 Predicted divalent cation transporter Cluster-8309.57299 BP_3 23.09 1.36 1112 270006684 EFA03132.1 744 3.9e-76 hypothetical protein TcasGA2_TC013044 [Tribolium castaneum] 642924851 XM_008195844.1 184 2.56407e-89 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- Q9Y266 550 5.0e-55 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.573 BP_3 2.00 0.51 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57301 BP_3 196.76 3.36 3111 91081997 XP_969187.1 655 2.3e-65 PREDICTED: pre-mRNA 3' end processing protein WDR33 [Tribolium castaneum]>gi|270007376|gb|EFA03824.1| hypothetical protein TcasGA2_TC013939 [Tribolium castaneum] 556962117 XM_005991191.1 60 6.23884e-20 PREDICTED: Latimeria chalumnae WD repeat domain 33 (WDR33), mRNA K15542 PFS2 polyadenylation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15542 Q9C0J8 558 1.6e-55 pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens GN=WDR33 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0284 Polyadenylation factor I complex, subunit PFS2 Cluster-8309.57302 BP_3 93.00 0.83 5722 270016002 EFA12450.1 1146 4.8e-122 hypothetical protein TcasGA2_TC016185 [Tribolium castaneum]>gi|270016905|gb|EFA13351.1| hypothetical protein TcasGA2_TC006959 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00770//PF02902//PF01637//PF02309//PF11654 Adenovirus endoprotease//Ulp1 protease family, C-terminal catalytic domain//Archaeal ATPase//AUX/IAA family//Protein of unknown function (DUF2665) GO:0009306//GO:0006508//GO:0006355 protein secretion//proteolysis//regulation of transcription, DNA-templated GO:0004197//GO:0008234//GO:0005524 cysteine-type endopeptidase activity//cysteine-type peptidase activity//ATP binding GO:0005634 nucleus -- -- Cluster-8309.57307 BP_3 47.59 2.61 1171 91083169 XP_972121.1 523 1.7e-50 PREDICTED: uncharacterized protein LOC660825 [Tribolium castaneum]>gi|270007697|gb|EFA04145.1| hypothetical protein TcasGA2_TC014389 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.57308 BP_3 67.23 3.37 1253 91083169 XP_972121.1 523 1.8e-50 PREDICTED: uncharacterized protein LOC660825 [Tribolium castaneum]>gi|270007697|gb|EFA04145.1| hypothetical protein TcasGA2_TC014389 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13508 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.57311 BP_3 38.60 0.90 2348 642932620 XP_008196923.1 1128 2.4e-120 PREDICTED: glucose dehydrogenase [FAD, quinone]-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 472 1.2e-45 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF03435//PF05834//PF00732//PF06068//PF05199//PF02558//PF07992//PF02254 FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//Lycopene cyclase protein//GMC oxidoreductase//TIP49 C-terminus//GMC oxidoreductase//Ketopantoate reductase PanE/ApbA//Pyridine nucleotide-disulphide oxidoreductase//TrkA-N domain GO:0016117//GO:0055114//GO:0015940//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//pantothenate biosynthetic process//potassium ion transport GO:0008677//GO:0050660//GO:0016614//GO:0003678//GO:0016705//GO:0005524//GO:0016491 2-dehydropantoate 2-reductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//DNA helicase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ATP binding//oxidoreductase activity GO:0005657 replication fork -- -- Cluster-8309.57312 BP_3 12.57 0.41 1763 478254983 ENN75216.1 228 4.2e-16 hypothetical protein YQE_08226, partial [Dendroctonus ponderosae]>gi|546678564|gb|ERL89153.1| hypothetical protein D910_06529 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q95LV7 148 3.2e-08 SUN domain-containing protein 3 OS=Macaca fascicularis GN=SUN3 PE=2 SV=1 PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.57315 BP_3 114.67 2.75 2301 642932618 XP_008196922.1 1605 1.2e-175 PREDICTED: glucose dehydrogenase [FAD, quinone]-like isoform X1 [Tribolium castaneum]>gi|270012387|gb|EFA08835.1| hypothetical protein TcasGA2_TC006533 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 722 1.2e-74 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF07992//PF05834//PF00732//PF05199//PF02254 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0055114//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//potassium ion transport GO:0050660//GO:0016614//GO:0016705//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- -- -- Cluster-8309.57317 BP_3 12.61 0.70 1165 478254983 ENN75216.1 306 2.5e-25 hypothetical protein YQE_08226, partial [Dendroctonus ponderosae]>gi|546678564|gb|ERL89153.1| hypothetical protein D910_06529 [Dendroctonus ponderosae] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 175 1.6e-11 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57319 BP_3 3.29 0.31 798 546675479 ERL86664.1 291 9.3e-24 hypothetical protein D910_04070 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57320 BP_3 18.00 1.62 826 795169273 XP_011798349.1 1349 2.0e-146 PREDICTED: elongation factor 1-alpha 1 [Colobus angolensis palliatus] 694986412 XM_001138897.4 731 0 PREDICTED: Pan troglodytes putative elongation factor 1-alpha-like 3 (LOC739210), mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q5R4R8 1349 8.3e-148 Elongation factor 1-alpha 1 OS=Pongo abelii GN=EEF1A1 PE=2 SV=2 PF01926//PF00503 50S ribosome-binding GTPase//G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0003924//GO:0031683//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.57321 BP_3 2.00 5.91 281 564344879 XP_006235797.1 388 1.9e-35 PREDICTED: elongation factor 1-alpha 2 isoform X2 [Rattus norvegicus] 675785536 XR_608502.1 281 7.06148e-144 PREDICTED: Pan paniscus elongation factor 1-alpha 1 pseudogene (LOC100985170), misc_RNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q71V39 381 4.9e-36 Elongation factor 1-alpha 2 OS=Oryctolagus cuniculus GN=EEF1A2 PE=1 SV=1 PF01580//PF06431//PF00503 FtsK/SpoIIIE family//Polyomavirus large T antigen C-terminus//G-protein alpha subunit GO:0006260//GO:0007186//GO:0007165 DNA replication//G-protein coupled receptor signaling pathway//signal transduction GO:0004871//GO:0019001//GO:0000166//GO:0003677//GO:0031683//GO:0005524//GO:0003924 signal transducer activity//guanyl nucleotide binding//nucleotide binding//DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.57324 BP_3 17.00 0.41 2311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57326 BP_3 18.21 0.40 2497 91089063 XP_970679.1 2031 5.0e-225 PREDICTED: N-sulphoglucosamine sulphohydrolase isoform X1 [Tribolium castaneum]>gi|270012406|gb|EFA08854.1| hypothetical protein TcasGA2_TC006555 [Tribolium castaneum] 584037463 XM_006753050.1 45 1.08927e-11 PREDICTED: Myotis davidii N-sulfoglucosamine sulfohydrolase (SGSH), partial mRNA K01565 SGSH N-sulfoglucosamine sulfohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01565 P51688 1498 1.3e-164 N-sulphoglucosamine sulphohydrolase OS=Homo sapiens GN=SGSH PE=1 SV=1 PF00010//PF00884//PF07931//PF01663//PF09004 Helix-loop-helix DNA-binding domain//Sulfatase//Chloramphenicol phosphotransferase-like protein//Type I phosphodiesterase / nucleotide pyrophosphatase//Domain of unknown function (DUF1891) GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0008484//GO:0008168//GO:0016706//GO:0046983//GO:0016740//GO:0005524//GO:0003824 sulfuric ester hydrolase activity//methyltransferase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//protein dimerization activity//transferase activity//ATP binding//catalytic activity -- -- KOG3867 Sulfatase Cluster-8309.57335 BP_3 45.45 2.51 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57338 BP_3 6.43 0.59 813 675363731 KFM56633.1 220 1.6e-15 Arginyl-tRNA--protein transferase 1, partial [Stegodyphus mimosarum] -- -- -- -- -- K00685 ATE1, ate1 arginine-tRNA-protein transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00685 O95260 207 2.2e-15 Arginyl-tRNA--protein transferase 1 OS=Homo sapiens GN=ATE1 PE=1 SV=2 PF04376 Arginine-tRNA-protein transferase, N terminus GO:0016598 protein arginylation GO:0004057 arginyltransferase activity -- -- KOG1193 Arginyl-tRNA-protein transferase Cluster-8309.57339 BP_3 299.00 21.63 958 91093713 XP_967373.1 1074 1.8e-114 PREDICTED: mitochondrial ubiquitin ligase activator of NFKB 1 [Tribolium castaneum]>gi|270013001|gb|EFA09449.1| hypothetical protein TcasGA2_TC010664 [Tribolium castaneum] -- -- -- -- -- K15688 MUL1 E3 ubiquitin-protein ligase MUL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15688 Q969V5 333 6.2e-30 Mitochondrial ubiquitin ligase activator of NFKB 1 OS=Homo sapiens GN=MUL1 PE=1 SV=1 PF12483 E3 Ubiquitin ligase GO:0016567//GO:0007005 protein ubiquitination//mitochondrion organization GO:0046872//GO:0004842//GO:0016881//GO:0008270 metal ion binding//ubiquitin-protein transferase activity//acid-amino acid ligase activity//zinc ion binding -- -- -- -- Cluster-8309.57340 BP_3 207.77 2.40 4459 357604009 EHJ64005.1 1337 2.7e-144 hypothetical protein KGM_07794 [Danaus plexippus] 815896313 XM_003485235.2 198 1.73459e-96 PREDICTED: Bombus impatiens cytoplasmic tRNA 2-thiolation protein 1 (LOC100747993), mRNA K14168 CTU1, NCS6 cytoplasmic tRNA 2-thiolation protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14168 B4KLL0 1292 1.8e-140 Cytoplasmic tRNA 2-thiolation protein 1 OS=Drosophila mojavensis GN=GI19452 PE=3 SV=1 PF13639//PF10288//PF14634 Ring finger domain//Cytoplasmic tRNA 2-thiolation protein 2//zinc-RING finger domain GO:0002098//GO:0034227 tRNA wobble uridine modification//tRNA thio-modification GO:0005515//GO:0000049//GO:0008270 protein binding//tRNA binding//zinc ion binding -- -- KOG2840 Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily Cluster-8309.57341 BP_3 3.41 0.73 516 189235393 XP_001810875.1 157 2.1e-08 PREDICTED: targeting protein for Xklp2 [Tribolium castaneum]>gi|270003583|gb|EFA00031.1| hypothetical protein TcasGA2_TC002838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5736 BP_3 39.70 1.07 2077 642921224 XP_008192769.1 1620 1.9e-177 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921235 XM_008194553.1 303 3.42369e-155 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 392 1.9e-36 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57370 BP_3 3.00 1.10 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57371 BP_3 10.00 0.31 1852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57375 BP_3 74.44 1.47 2729 642925278 XP_008194489.1 1289 6.0e-139 PREDICTED: PAX-interacting protein 1 [Tribolium castaneum]>gi|270009278|gb|EFA05726.1| hypothetical protein TcasGA2_TC015410 [Tribolium castaneum] -- -- -- -- -- K14972 PAXIP1, PTIP PAX-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14972 Q6ZW49 393 2.0e-36 PAX-interacting protein 1 OS=Homo sapiens GN=PAXIP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.57377 BP_3 1.00 0.54 379 260814490 XP_002601948.1 139 1.9e-06 hypothetical protein BRAFLDRAFT_86432 [Branchiostoma floridae]>gi|229287251|gb|EEN57960.1| hypothetical protein BRAFLDRAFT_86432 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06397//PF05495//PF00096//PF02085 Desulfoferrodoxin, N-terminal domain//CHY zinc finger//Zinc finger, C2H2 type//Class III cytochrome C family GO:0006118 obsolete electron transport GO:0005506//GO:0046872//GO:0020037//GO:0008270//GO:0009055 iron ion binding//metal ion binding//heme binding//zinc ion binding//electron carrier activity -- -- -- -- Cluster-8309.57379 BP_3 30.39 0.53 3074 91083833 XP_973697.1 435 7.2e-40 PREDICTED: endocuticle structural glycoprotein SgAbd-8 [Tribolium castaneum]>gi|270006770|gb|EFA03218.1| hypothetical protein TcasGA2_TC013138 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 219 3.3e-16 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.57380 BP_3 50.45 0.71 3724 642918712 XP_008191550.1 1452 1.0e-157 PREDICTED: phospholipase D2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 P70496 674 7.0e-69 Phospholipase D1 OS=Rattus norvegicus GN=Pld1 PE=1 SV=3 PF02399//PF00614//PF00787 Origin of replication binding protein//Phospholipase D Active site motif//PX domain GO:0006260 DNA replication GO:0035091//GO:0003688//GO:0005524//GO:0003824 phosphatidylinositol binding//DNA replication origin binding//ATP binding//catalytic activity GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.57385 BP_3 30.09 1.94 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57390 BP_3 1.00 0.39 413 768451083 XP_011567718.1 195 6.5e-13 PREDICTED: uncharacterized protein LOC105397399 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57392 BP_3 579.94 26.97 1328 91087565 XP_971161.1 1263 3.0e-136 PREDICTED: RNA 3'-terminal phosphate cyclase [Tribolium castaneum]>gi|642930249|ref|XP_008196316.1| PREDICTED: RNA 3'-terminal phosphate cyclase [Tribolium castaneum] -- -- -- -- -- K01974 RTCA, rtcA RNA 3'-terminal phosphate cyclase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K01974 Q9D7H3 896 4.5e-95 RNA 3'-terminal phosphate cyclase OS=Mus musculus GN=RtcA PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.57393 BP_3 38.34 1.07 2020 625273551 XP_007628350.1 527 1.0e-50 PREDICTED: zinc finger protein 14-like isoform X4 [Cricetulus griseus] -- -- -- -- -- -- -- -- -- Q5XIU2 811 4.9e-85 Zinc finger protein 143 OS=Rattus norvegicus GN=Znf143 PE=2 SV=2 PF13912//PF00962//PF13465//PF00096 C2H2-type zinc finger//Adenosine/AMP deaminase//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0019239//GO:0046872 deaminase activity//metal ion binding -- -- -- -- Cluster-8309.57397 BP_3 440.66 6.17 3732 642923482 XP_008193528.1 402 5.9e-36 PREDICTED: hyccin [Tribolium castaneum] 642923486 XM_008195309.1 166 8.91077e-79 PREDICTED: Tribolium castaneum RNA binding protein fox-1 homolog 3 (LOC655682), transcript variant X3, mRNA K14946 RBFOX, FOX RNA binding protein fox-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14946 Q0VD23 234 7.3e-18 RNA binding protein fox-1 homolog 3 OS=Bos taurus GN=RBFOX3 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.57402 BP_3 40.07 0.63 3359 270006660 EFA03108.1 826 3.6e-85 hypothetical protein TcasGA2_TC013018 [Tribolium castaneum] 805796309 XM_012287860.1 44 5.28615e-11 PREDICTED: Megachile rotundata SUN domain-containing ossification factor (LOC100876839), transcript variant X4, mRNA -- -- -- -- Q710E6 563 4.7e-56 SUN domain-containing ossification factor OS=Rattus norvegicus GN=Suco PE=2 SV=1 PF11629//PF03739//PF15281 C terminal SARAH domain of Mst1//Predicted permease YjgP/YjgQ family//Consortin C-terminus GO:0016310//GO:0009069//GO:0042998 phosphorylation//serine family amino acid metabolic process//positive regulation of Golgi to plasma membrane protein transport GO:0071253//GO:0004674 connexin binding//protein serine/threonine kinase activity GO:0005802//GO:0016021 trans-Golgi network//integral component of membrane KOG1396 Uncharacterized conserved protein Cluster-8309.57404 BP_3 191.20 2.94 3429 270006660 EFA03108.1 826 3.7e-85 hypothetical protein TcasGA2_TC013018 [Tribolium castaneum] 805796309 XM_012287860.1 44 5.39751e-11 PREDICTED: Megachile rotundata SUN domain-containing ossification factor (LOC100876839), transcript variant X4, mRNA -- -- -- -- Q710E6 563 4.8e-56 SUN domain-containing ossification factor OS=Rattus norvegicus GN=Suco PE=2 SV=1 PF15281//PF03739//PF11629 Consortin C-terminus//Predicted permease YjgP/YjgQ family//C terminal SARAH domain of Mst1 GO:0009069//GO:0042998//GO:0016310 serine family amino acid metabolic process//positive regulation of Golgi to plasma membrane protein transport//phosphorylation GO:0071253//GO:0004674 connexin binding//protein serine/threonine kinase activity GO:0005802//GO:0016021 trans-Golgi network//integral component of membrane KOG1396 Uncharacterized conserved protein Cluster-8309.57405 BP_3 193.73 3.03 3378 270006660 EFA03108.1 826 3.6e-85 hypothetical protein TcasGA2_TC013018 [Tribolium castaneum] 805796309 XM_012287860.1 44 5.31638e-11 PREDICTED: Megachile rotundata SUN domain-containing ossification factor (LOC100876839), transcript variant X4, mRNA -- -- -- -- Q710E6 563 4.7e-56 SUN domain-containing ossification factor OS=Rattus norvegicus GN=Suco PE=2 SV=1 PF15281//PF03739//PF11629 Consortin C-terminus//Predicted permease YjgP/YjgQ family//C terminal SARAH domain of Mst1 GO:0016310//GO:0009069//GO:0042998 phosphorylation//serine family amino acid metabolic process//positive regulation of Golgi to plasma membrane protein transport GO:0071253//GO:0004674 connexin binding//protein serine/threonine kinase activity GO:0016021//GO:0005802 integral component of membrane//trans-Golgi network KOG1396 Uncharacterized conserved protein Cluster-8309.57412 BP_3 126.21 0.70 8991 270007727 EFA04175.1 2353 8.3e-262 hypothetical protein TcasGA2_TC014424 [Tribolium castaneum] 642923781 XM_008195660.1 114 1.74062e-49 PREDICTED: Tribolium castaneum regulating synaptic membrane exocytosis protein 2 (LOC663311), mRNA K15297 RIMS2, RIM2 regulating synaptic membrane exocytosis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15297 Q9UQ26 647 2.3e-65 Regulating synaptic membrane exocytosis protein 2 OS=Homo sapiens GN=RIMS2 PE=1 SV=2 PF00168//PF00595 C2 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG2060 Rab3 effector RIM1 and related proteins, contain PDZ and C2 domains Cluster-8309.57413 BP_3 161.41 3.31 2643 270001539 EEZ97986.1 2008 2.5e-222 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 5.69656e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1089 3.7e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.57418 BP_3 25.00 0.33 3962 597761729 XP_007244846.1 193 1.1e-11 PREDICTED: remodeling and spacing factor 1-like isoform X1 [Astyanax mexicanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02163//PF03410 Peptidase family M50//Metallopeptidase from vaccinia pox GO:0006508//GO:0019058 proteolysis//viral life cycle GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.57422 BP_3 166.72 3.18 2817 642921802 XP_008199325.1 715 2.3e-72 PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum]>gi|642921804|ref|XP_008199326.1| PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9R007 146 8.8e-08 C-type lectin domain family 5 member A OS=Mus musculus GN=Clec5a PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57423 BP_3 249.60 4.78 2807 642921802 XP_008199325.1 715 2.2e-72 PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum]>gi|642921804|ref|XP_008199326.1| PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9R007 146 8.8e-08 C-type lectin domain family 5 member A OS=Mus musculus GN=Clec5a PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57426 BP_3 30.67 0.63 2639 270009986 EFA06434.1 203 5.0e-13 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03359 Guanylate-kinase-associated protein (GKAP) protein GO:0023052 signaling -- -- -- -- -- -- Cluster-8309.5743 BP_3 11.79 2.34 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57430 BP_3 6.15 0.40 1026 675372920 KFM65822.1 148 4.6e-07 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.57432 BP_3 4.00 0.40 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03604 DNA directed RNA polymerase, 7 kDa subunit GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.57433 BP_3 453.25 14.29 1821 642918767 XP_008191575.1 1237 4.3e-133 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9Y251 732 6.4e-76 Heparanase OS=Homo sapiens GN=HPSE PE=1 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.57434 BP_3 12.84 0.39 1874 91093431 XP_969079.1 530 4.2e-51 PREDICTED: AMMECR1-like protein [Tribolium castaneum]>gi|270015455|gb|EFA11903.1| hypothetical protein TcasGA2_TC004060 [Tribolium castaneum] 880861289 XM_005065312.2 58 4.82803e-19 PREDICTED: Mesocricetus auratus AMMECR1-like (Ammecr1l), transcript variant X3, mRNA -- -- -- -- Q5RAS7 441 3.7e-42 AMME syndrome candidate gene 1 protein homolog OS=Pongo abelii GN=AMMECR1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3274 Uncharacterized conserved protein, AMMECR1 Cluster-8309.57438 BP_3 5.00 0.53 750 642936671 XP_008198532.1 208 3.7e-14 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K10859 ALKBH2 alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10859 Q6P6J4 178 4.6e-12 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 OS=Mus musculus GN=Alkbh2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57440 BP_3 14.36 0.56 1536 340722244 XP_003399518.1 479 2.9e-45 PREDICTED: serine/threonine-protein kinase pelle [Bombus terrestris]>gi|808135085|ref|XP_012169964.1| PREDICTED: serine/threonine-protein kinase pelle [Bombus terrestris]>gi|808135087|ref|XP_012169965.1| PREDICTED: serine/threonine-protein kinase pelle [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q05652 186 1.1e-12 Serine/threonine-protein kinase pelle OS=Drosophila melanogaster GN=pll PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG1187 Serine/threonine protein kinase Cluster-8309.57441 BP_3 2.00 0.67 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57442 BP_3 783.05 4.77 8198 242005002 XP_002423364.1 1695 1.5e-185 hormone receptor hr3, putative [Pediculus humanus corporis]>gi|212506394|gb|EEB10626.1| hormone receptor hr3, putative [Pediculus humanus corporis] 642929407 XM_008197603.1 666 0 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X3, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P49868 753 1.1e-77 Probable nuclear hormone receptor HR3 OS=Galleria mellonella GN=HR3 PE=2 SV=1 PF00104//PF07998//PF00105 Ligand-binding domain of nuclear hormone receptor//Peptidase family M54//Zinc finger, C4 type (two domains) GO:0009987//GO:0043401//GO:0006355 cellular process//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0005488//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4216 Steroid hormone nuclear receptor Cluster-8309.57448 BP_3 9.69 0.43 1389 642930048 XP_008196227.1 1464 1.6e-159 PREDICTED: dynein intermediate chain 2, ciliary [Tribolium castaneum]>gi|270009429|gb|EFA05877.1| hypothetical protein TcasGA2_TC008686 [Tribolium castaneum] -- -- -- -- -- K10409 DNAI1 dynein intermediate chain 1, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10409 Q16959 853 4.5e-90 Dynein intermediate chain 2, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57456 BP_3 6.00 3.37 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57459 BP_3 257.59 3.53 3804 91079364 XP_970368.1 4390 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917122|ref|XP_008191123.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917124|ref|XP_008191125.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|270004364|gb|EFA00812.1| hypothetical protein TcasGA2_TC003699 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P5W1 1514 2.8e-166 Vacuolar protein sorting-associated protein 8 homolog OS=Mus musculus GN=Vps8 PE=2 SV=1 PF12678//PF02148//PF17123//PF14634//PF00628//PF17122//PF13639//PF00637//PF13374 RING-H2 zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//RING-like zinc finger//zinc-RING finger domain//PHD-finger//Zinc-finger//Ring finger domain//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005622 intracellular KOG2079 Vacuolar assembly/sorting protein VPS8 Cluster-8309.5746 BP_3 203.88 3.00 3565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57460 BP_3 563.97 14.93 2112 642937669 XP_008198894.1 1444 5.0e-157 PREDICTED: uncharacterized protein LOC103314480 [Tribolium castaneum]>gi|270001142|gb|EEZ97589.1| hypothetical protein TcasGA2_TC011452 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02119 Flagellar P-ring protein GO:0071973 bacterial-type flagellum-dependent cell motility GO:0005198//GO:0016772 structural molecule activity//transferase activity, transferring phosphorus-containing groups GO:0030288//GO:0009428 outer membrane-bounded periplasmic space//bacterial-type flagellum basal body, distal rod, P ring -- -- Cluster-8309.57466 BP_3 19.00 0.75 1509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57468 BP_3 127.86 6.82 1196 761901546 XP_011404925.1 340 2.9e-29 PREDICTED: uncharacterized protein LOC100639010 [Amphimedon queenslandica] -- -- -- -- -- -- -- -- -- Q1RK13 304 1.8e-26 Putative ankyrin repeat protein RBE_0220 OS=Rickettsia bellii (strain RML369-C) GN=RBE_0220 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.5747 BP_3 4.00 0.81 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.57472 BP_3 789.43 66.96 860 642926280 XP_008194858.1 524 9.7e-51 PREDICTED: uncharacterized protein LOC103313420 isoform X1 [Tribolium castaneum]>gi|270008508|gb|EFA04956.1| hypothetical protein TcasGA2_TC015025 [Tribolium castaneum] 749773866 XM_011143969.1 81 3.55366e-32 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X1, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57475 BP_3 9.58 1.11 708 270004586 EFA01034.1 396 5.5e-36 hypothetical protein TcasGA2_TC003950 [Tribolium castaneum] 194759499 XM_001961949.1 37 8.35258e-08 Drosophila ananassae GF14663 (Dana\GF14663), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8NB50 336 2.1e-30 Zinc finger protein 62 homolog OS=Homo sapiens GN=ZFP62 PE=2 SV=3 PF13465//PF00096//PF13912//PF01363 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.57476 BP_3 7.00 0.74 745 270004588 EFA01036.1 244 2.5e-18 hypothetical protein TcasGA2_TC003952 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C827 211 6.8e-16 Zinc finger protein 62 OS=Mus musculus GN=Zfp62 PE=2 SV=1 PF00096//PF00130//PF13465//PF00412//PF04810//PF01363//PF13912//PF01428 Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//LIM domain//Sec23/Sec24 zinc finger//FYVE zinc finger//C2H2-type zinc finger//AN1-like Zinc finger GO:0006886//GO:0006888//GO:0035556 intracellular protein transport//ER to Golgi vesicle-mediated transport//intracellular signal transduction GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.57480 BP_3 68.13 0.99 3608 642915507 XP_008190646.1 462 6.3e-43 PREDICTED: suppressor of cytokine signaling 6 [Tribolium castaneum]>gi|270004015|gb|EFA00463.1| hypothetical protein TcasGA2_TC003320 [Tribolium castaneum] -- -- -- -- -- K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q9JLY0 390 5.8e-36 Suppressor of cytokine signaling 6 OS=Mus musculus GN=Socs6 PE=1 SV=2 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.57481 BP_3 34.23 2.07 1090 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57483 BP_3 27.97 0.83 1912 189234350 XP_973716.2 1510 1.0e-164 PREDICTED: probable cysteine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q8BYM8 944 1.8e-100 Probable cysteine--tRNA ligase, mitochondrial OS=Mus musculus GN=Cars2 PE=2 SV=2 PF16954//PF09190//PF00133//PF09334 Haem-transporter, endosomal/lysosomal, haem-responsive gene//DALR domain//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0006423//GO:0006418//GO:0015886//GO:0006534 cysteinyl-tRNA aminoacylation//tRNA aminoacylation for protein translation//heme transport//cysteine metabolic process GO:0004817//GO:0000166//GO:0004812//GO:0005524//GO:0015232 cysteine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity//ATP binding//heme transporter activity GO:0005737 cytoplasm KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.57484 BP_3 13.55 0.38 1998 270001919 EEZ98366.1 1469 5.9e-160 hypothetical protein TcasGA2_TC000823 [Tribolium castaneum] -- -- -- -- -- K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q8BYM8 905 6.1e-96 Probable cysteine--tRNA ligase, mitochondrial OS=Mus musculus GN=Cars2 PE=2 SV=2 PF16954//PF00579//PF09190//PF00133//PF09334 Haem-transporter, endosomal/lysosomal, haem-responsive gene//tRNA synthetases class I (W and Y)//DALR domain//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0006534//GO:0015886//GO:0006418//GO:0006423 cysteine metabolic process//heme transport//tRNA aminoacylation for protein translation//cysteinyl-tRNA aminoacylation GO:0015232//GO:0005524//GO:0004812//GO:0004817//GO:0000166 heme transporter activity//ATP binding//aminoacyl-tRNA ligase activity//cysteine-tRNA ligase activity//nucleotide binding GO:0005737 cytoplasm KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.57487 BP_3 365.00 9.37 2169 642929096 XP_974387.2 1754 5.8e-193 PREDICTED: eyes absent homolog 2 [Tribolium castaneum] -- -- -- -- -- K15616 EYA1 eyes absent homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15616 Q99502 1125 2.1e-121 Eyes absent homolog 1 OS=Homo sapiens GN=EYA1 PE=1 SV=2 PF12906//PF12678//PF00097//PF13639 RING-variant domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG3107 Predicted haloacid dehalogenase-like hydrolase (eyes absent) Cluster-8309.57490 BP_3 42.60 4.46 752 91088597 XP_973576.1 415 3.7e-38 PREDICTED: ketimine reductase mu-crystallin [Tribolium castaneum]>gi|270012255|gb|EFA08703.1| hypothetical protein TcasGA2_TC006374 [Tribolium castaneum] -- -- -- -- -- K18258 CRYM thiomorpholine-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18258 Q14894 266 2.9e-22 Ketimine reductase mu-crystallin OS=Homo sapiens GN=CRYM PE=1 SV=1 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0003824//GO:0004488 catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG3007 Mu-crystallin Cluster-8309.57493 BP_3 50.00 1.64 1761 391334509 XP_003741646.1 635 2.7e-63 PREDICTED: uncharacterized protein LOC100899549 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03882 KicB killing factor GO:0007059//GO:0006260 chromosome segregation//DNA replication GO:0005509 calcium ion binding GO:0005737 cytoplasm -- -- Cluster-8309.57495 BP_3 27.00 1.01 1574 146182859 XP_001025435.2 145 1.6e-06 CnjB protein [Tetrahymena thermophila SB210]>gi|146143687|gb|EAS05190.2| CnjB protein [Tetrahymena thermophila SB210] -- -- -- -- -- -- -- -- -- Q8WW36 130 3.5e-06 Zinc finger CCHC domain-containing protein 13 OS=Homo sapiens GN=ZCCHC13 PE=1 SV=1 PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.57496 BP_3 63.98 0.84 3942 270015258 EFA11706.1 1221 6.7e-131 hypothetical protein TcasGA2_TC001793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10394 354 9.4e-32 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.57497 BP_3 84.00 0.69 6150 270017072 EFA13518.1 1297 1.6e-139 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1001 1.4e-106 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.57498 BP_3 5.00 0.36 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57501 BP_3 90.00 1.72 2814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57503 BP_3 1.00 28.47 218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57504 BP_3 15.00 2.69 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57506 BP_3 142.00 2.83 2711 642918511 XP_008191503.1 368 3.7e-32 PREDICTED: uncharacterized protein LOC103312504 [Tribolium castaneum]>gi|270003218|gb|EEZ99665.1| hypothetical protein TcasGA2_TC002422 [Tribolium castaneum] -- -- -- -- -- K16453 CCP110, CEP110 centrosomal protein CEP110 http://www.genome.jp/dbget-bin/www_bget?ko:K16453 O43303 155 7.7e-09 Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens GN=CCP110 PE=1 SV=3 PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57507 BP_3 33.92 3.22 800 642925861 XP_008190588.1 863 4.4e-90 PREDICTED: osmotic avoidance abnormal protein 3 [Tribolium castaneum] -- -- -- -- -- K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q9P2E2 637 2.9e-65 Kinesin-like protein KIF17 OS=Homo sapiens GN=KIF17 PE=2 SV=3 PF08477//PF00225 Ras of Complex, Roc, domain of DAPkinase//Kinesin motor domain GO:0007018//GO:0007017//GO:0007264 microtubule-based movement//microtubule-based process//small GTPase mediated signal transduction GO:0005524//GO:0003777//GO:0005525//GO:0008017 ATP binding//microtubule motor activity//GTP binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG4280 Kinesin-like protein Cluster-8309.57508 BP_3 26.52 0.58 2486 170321839 BAG14264.1 698 1.9e-70 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- O00187 253 3.1e-20 Mannan-binding lectin serine protease 2 OS=Homo sapiens GN=MASP2 PE=1 SV=4 PF04272 Phospholamban GO:0006810//GO:0006816 transport//calcium ion transport GO:0042030//GO:0005246 ATPase inhibitor activity//calcium channel regulator activity GO:0016020 membrane -- -- Cluster-8309.57514 BP_3 25.00 1.27 1237 61652776 AAX47960.1 524 1.4e-50 prophenoloxidase activating factor serine proteinase [Scylla serrata] -- -- -- -- -- K08670 ST14, PRSS14 suppressor of tumorigenicity protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08670 Q6SA95 371 3.1e-34 Coagulation factor IX OS=Felis catus GN=F9 PE=3 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.57516 BP_3 66.87 1.39 2617 270006980 EFA03428.1 972 3.3e-102 hypothetical protein TcasGA2_TC013417 [Tribolium castaneum] -- -- -- -- -- K12021 TRIM45 tripartite motif-containing protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K12021 Q6PFY8 294 5.7e-25 Tripartite motif-containing protein 45 OS=Mus musculus GN=Trim45 PE=2 SV=2 PF13639//PF09803//PF00097//PF14634//PF00643 Ring finger domain//Uncharacterized conserved protein (DUF2346)//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//B-box zinc finger GO:0033617 mitochondrial respiratory chain complex IV assembly GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005739//GO:0005622 mitochondrion//intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.57518 BP_3 442.61 4.80 4740 642926758 XP_008195001.1 1018 2.8e-107 PREDICTED: gastrula zinc finger protein XlCGF52.1-like [Tribolium castaneum]>gi|270008400|gb|EFA04848.1| hypothetical protein TcasGA2_TC014900 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 464 2.0e-44 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF12937//PF13465//PF00096//PF00646//PF07776//PF15966//PF13912 F-box-like//Zinc-finger double domain//Zinc finger, C2H2 type//F-box domain//Zinc-finger associated domain (zf-AD)//F-box//C2H2-type zinc finger -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.5752 BP_3 38.51 1.02 2108 820805578 AKG92780.1 1488 3.9e-162 deadpan [Leptinotarsa decemlineata] -- -- -- -- -- K09090 HESN hairy and enhancer of split, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09090 Q26263 572 2.7e-57 Protein deadpan OS=Drosophila melanogaster GN=dpn PE=1 SV=2 PF00010//PF07527 Helix-loop-helix DNA-binding domain//Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.57520 BP_3 177.24 7.56 1422 478257453 ENN77609.1 221 2.2e-15 hypothetical protein YQE_05904, partial [Dendroctonus ponderosae]>gi|546679848|gb|ERL90236.1| hypothetical protein D910_07589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57524 BP_3 86.03 1.82 2576 270010125 EFA06573.1 207 1.7e-13 hypothetical protein TcasGA2_TC009484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-8309.57527 BP_3 48.45 0.74 3466 642914233 XP_008201600.1 1751 2.1e-192 PREDICTED: zinc finger protein 532-like [Tribolium castaneum]>gi|642914235|ref|XP_008201601.1| PREDICTED: zinc finger protein 532-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1G0 226 5.8e-17 Zinc finger protein 687 OS=Homo sapiens GN=ZNF687 PE=1 SV=1 PF16622//PF09520//PF13912//PF13465//PF00096 zinc-finger C2H2-type//Type II restriction endonuclease, TdeIII//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0046872//GO:0009036//GO:0003677 metal ion binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.57529 BP_3 14.00 0.78 1162 642933039 XP_008197239.1 756 1.6e-77 PREDICTED: neo-calmodulin-like isoform X1 [Tribolium castaneum] 642933042 XM_966204.3 205 5.67888e-101 PREDICTED: Tribolium castaneum neo-calmodulin-like (LOC659938), transcript variant X3, mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02594 345 3.1e-31 Calmodulin OS=Electrophorus electricus GN=calm PE=2 SV=2 PF13833//PF10591//PF13405//PF00036//PF13499//PF13202//PF12763 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.5753 BP_3 27.66 1.01 1617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02536 mTERF GO:0006355 regulation of transcription, DNA-templated GO:0003690 double-stranded DNA binding GO:0005739 mitochondrion -- -- Cluster-8309.57530 BP_3 697.00 18.27 2131 198427319 XP_002121818.1 333 3.4e-28 PREDICTED: aprataxin and PNK-like factor [Ciona intestinalis] -- -- -- -- -- K13295 APLF aprataxin and PNK-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13295 Q8IW19 230 1.2e-17 Aprataxin and PNK-like factor OS=Homo sapiens GN=APLF PE=1 SV=1 PF00822//PF00498 PMP-22/EMP/MP20/Claudin family//FHA domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.57532 BP_3 28.46 0.61 2540 270004214 EFA00662.1 366 6.0e-32 hypothetical protein TcasGA2_TC003538 [Tribolium castaneum] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 148 4.7e-08 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57533 BP_3 27.00 0.50 2881 662195961 XP_008470989.1 792 2.7e-81 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57534 BP_3 11.00 1.34 688 261289447 XP_002603167.1 137 5.8e-06 hypothetical protein BRAFLDRAFT_63199 [Branchiostoma floridae]>gi|229288483|gb|EEN59178.1| hypothetical protein BRAFLDRAFT_63199 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57537 BP_3 83.70 0.75 5679 270013163 EFA09611.1 913 5.0e-95 hypothetical protein TcasGA2_TC011732 [Tribolium castaneum] 194880702 XM_001974468.1 91 6.69828e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF08022//PF00041//PF16656 FAD-binding domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0055114//GO:0019497 riboflavin metabolic process//oxidation-reduction process//hexachlorocyclohexane metabolic process GO:0003993//GO:0016491//GO:0005515//GO:0046872 acid phosphatase activity//oxidoreductase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.5754 BP_3 61.34 2.31 1569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02536 mTERF GO:0006355 regulation of transcription, DNA-templated GO:0003690 double-stranded DNA binding GO:0005739 mitochondrion -- -- Cluster-8309.57540 BP_3 4.00 0.31 916 478255653 ENN75865.1 243 4.0e-18 hypothetical protein YQE_07594, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57543 BP_3 52.61 1.28 2276 780633762 XP_011686120.1 148 1.0e-06 PREDICTED: uncharacterized protein LOC105448935 isoform X1 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08468 Methyltransferase small domain N-terminal GO:0006364//GO:0000154//GO:0006396 rRNA processing//rRNA modification//RNA processing GO:0008990 rRNA (guanine-N2-)-methyltransferase activity -- -- -- -- Cluster-8309.57544 BP_3 33.87 0.58 3121 28435510 AAL78163.1 2756 5.4e-309 phosphoenolpyruvate-carboxykinase [Neohelice granulata] 28435509 AY074922.1 1172 0 Chasmagnathus granulata phosphoenolpyruvate-carboxykinase (PEPCK) mRNA, complete cds K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 Q16822 2273 2.2e-254 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens GN=PCK2 PE=1 SV=3 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.57545 BP_3 102.13 2.35 2385 28435510 AAL78163.1 2756 4.1e-309 phosphoenolpyruvate-carboxykinase [Neohelice granulata] 28435509 AY074922.1 1187 0 Chasmagnathus granulata phosphoenolpyruvate-carboxykinase (PEPCK) mRNA, complete cds K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 Q16822 2273 1.7e-254 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens GN=PCK2 PE=1 SV=3 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.57546 BP_3 17.13 0.55 1790 642936096 XP_008198301.1 931 1.3e-97 PREDICTED: PR domain zinc finger protein 10-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4F6U4 262 2.0e-21 PR domain zinc finger protein 10 OS=Xenopus tropicalis GN=prdm10 PE=2 SV=1 PF00856//PF02226 SET domain//Picornavirus coat protein (VP4) -- -- GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0019028 viral capsid -- -- Cluster-8309.57547 BP_3 66.43 1.61 2277 642936094 XP_008198300.1 1991 2.0e-220 PREDICTED: PR domain zinc finger protein 10-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4F6U4 394 1.3e-36 PR domain zinc finger protein 10 OS=Xenopus tropicalis GN=prdm10 PE=2 SV=1 PF00096//PF13465//PF00856//PF13912//PF02226 Zinc finger, C2H2 type//Zinc-finger double domain//SET domain//C2H2-type zinc finger//Picornavirus coat protein (VP4) -- -- GO:0005515//GO:0046872//GO:0005198 protein binding//metal ion binding//structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.57548 BP_3 57.94 0.53 5576 642915644 XP_972006.3 2069 4.4e-229 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.5e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.57549 BP_3 299.67 2.79 5465 546681139 ERL91289.1 1495 1.6e-162 hypothetical protein D910_08622 [Dendroctonus ponderosae] -- -- -- -- -- K10865 MRE11 double-strand break repair protein MRE11 http://www.genome.jp/dbget-bin/www_bget?ko:K10865 Q9W6K1 1099 5.3e-118 Double-strand break repair protein MRE11 OS=Xenopus laevis GN=mre11 PE=2 SV=1 PF00149//PF00614//PF09003//PF04152 Calcineurin-like phosphoesterase//Phospholipase D Active site motif//Bacteriophage lambda integrase, N-terminal domain//Mre11 DNA-binding presumed domain GO:0006302//GO:0015074 double-strand break repair//DNA integration GO:0003677//GO:0016787//GO:0003824//GO:0004519//GO:0030145//GO:0008907 DNA binding//hydrolase activity//catalytic activity//endonuclease activity//manganese ion binding//integrase activity GO:0005634 nucleus KOG2310 DNA repair exonuclease MRE11 Cluster-8309.57552 BP_3 124.11 2.41 2774 642940152 XP_008194842.1 1239 3.9e-133 PREDICTED: myoneurin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 337 6.2e-30 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF00651//PF02714 BTB/POZ domain//Calcium-dependent channel, 7TM region, putative phosphate -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.57565 BP_3 3.00 6.06 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57567 BP_3 3.00 0.32 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57570 BP_3 53.00 4.57 851 270001056 EEZ97503.1 293 5.8e-24 hypothetical protein TcasGA2_TC011347 [Tribolium castaneum] -- -- -- -- -- K18186 PET100 protein PET100, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K18186 P0DJE0 182 1.8e-12 Protein PET100 homolog, mitochondrial OS=Mus musculus GN=Pet100 PE=1 SV=1 PF09803 Uncharacterized conserved protein (DUF2346) GO:0033617 mitochondrial respiratory chain complex IV assembly -- -- GO:0005739 mitochondrion -- -- Cluster-8309.57571 BP_3 66.21 0.66 5130 642928752 XP_008199768.1 3712 0.0e+00 PREDICTED: nephrin isoform X1 [Tribolium castaneum]>gi|642928754|ref|XP_008199769.1| PREDICTED: nephrin isoform X1 [Tribolium castaneum] 642928753 XM_008201547.1 607 0 PREDICTED: Tribolium castaneum nephrin (LOC663184), transcript variant X2, mRNA -- -- -- -- Q9QZS7 218 7.2e-16 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57573 BP_3 128.39 1.56 4246 642914918 XP_008190441.1 1326 4.8e-143 PREDICTED: WD repeat-containing protein 34-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96EX3 372 8.3e-34 WD repeat-containing protein 34 OS=Homo sapiens GN=WDR34 PE=1 SV=2 PF03306//PF00400//PF14895//PF12515 Alpha-acetolactate decarboxylase//WD domain, G-beta repeat//Protein phosphatase 1 inhibitor//Ca2+-ATPase N terminal autoinhibitory domain GO:0045151//GO:0010923 acetoin biosynthetic process//negative regulation of phosphatase activity GO:0047605//GO:0005515//GO:0005516//GO:0019902 acetolactate decarboxylase activity//protein binding//calmodulin binding//phosphatase binding -- -- KOG3134 Predicted membrane protein Cluster-8309.57578 BP_3 16.61 0.34 2660 270015672 EFA12120.1 272 5.0e-21 hypothetical protein TcasGA2_TC002266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.57580 BP_3 18.81 0.95 1243 478254276 ENN74530.1 570 6.5e-56 hypothetical protein YQE_08854, partial [Dendroctonus ponderosae] -- -- -- -- -- K00566 mnmA, trmU, TRMU tRNA-specific 2-thiouridylase http://www.genome.jp/dbget-bin/www_bget?ko:K00566 Q503J2 457 3.4e-44 Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Danio rerio GN=trmu PE=2 SV=1 PF02568//PF00733 Thiamine biosynthesis protein (ThiI)//Asparagine synthase GO:0008033//GO:0006531//GO:0006522//GO:0006529 tRNA processing//aspartate metabolic process//alanine metabolic process//asparagine biosynthetic process GO:0004066//GO:0004810 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity -- -- KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Cluster-8309.57582 BP_3 7.41 10.58 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57583 BP_3 52.54 1.66 1819 91077266 XP_974141.1 821 7.5e-85 PREDICTED: trypsin-1 [Tribolium castaneum]>gi|270002819|gb|EEZ99266.1| serine protease P22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBI0 309 7.2e-27 Transmembrane protease serine 6 OS=Mus musculus GN=Tmprss6 PE=1 SV=4 PF02679//PF00089 (2R)-phospho-3-sulfolactate synthase (ComA)//Trypsin GO:0019295//GO:0006508 coenzyme M biosynthetic process//proteolysis GO:0008236//GO:0004252 serine-type peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.57584 BP_3 3.00 0.41 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57586 BP_3 7.00 0.69 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57588 BP_3 227.00 14.32 1056 91094675 XP_967123.1 931 7.6e-98 PREDICTED: stromal cell-derived factor 2 [Tribolium castaneum]>gi|270016502|gb|EFA12948.1| hypothetical protein TcasGA2_TC005068 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99470 561 2.5e-56 Stromal cell-derived factor 2 OS=Homo sapiens GN=SDF2 PE=1 SV=2 PF02815 MIR domain -- -- -- -- GO:0016020 membrane KOG3358 Uncharacterized secreted protein SDF2 (Stromal cell-derived factor 2), contains MIR domains Cluster-8309.57590 BP_3 71.82 1.52 2576 642924466 XP_001813222.2 1508 2.3e-164 PREDICTED: peroxisome biogenesis protein 1 [Tribolium castaneum]>gi|270007904|gb|EFA04352.1| hypothetical protein TcasGA2_TC014648 [Tribolium castaneum] -- -- -- -- -- K13338 PEX1 peroxin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K13338 O43933 502 4.2e-49 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 PF06068//PF01443//PF05496//PF00437//PF03266//PF03193//PF07726//PF00005//PF00493//PF00910//PF07728//PF01695//PF00158//PF01926//PF00004//PF09262//PF02367//PF06414//PF02562//PF00931//PF01580 TIP49 C-terminus//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//NTPase//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//MCM2/3/5 family//RNA helicase//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Peroxisome biogenesis factor 1, N-terminal//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein//NB-ARC domain//FtsK/SpoIIIE family GO:0006355//GO:0006260//GO:0006810//GO:0006281//GO:0002949//GO:0006310//GO:0007031 regulation of transcription, DNA-templated//DNA replication//transport//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//peroxisome organization GO:0000166//GO:0016301//GO:0016887//GO:0005524//GO:0098519//GO:0008134//GO:0003924//GO:0005525//GO:0009378//GO:0003724//GO:0003678//GO:0003723//GO:0003677//GO:0043531 nucleotide binding//kinase activity//ATPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//GTPase activity//GTP binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding//DNA binding//ADP binding GO:0009379//GO:0005657//GO:0005777//GO:0005667 Holliday junction helicase complex//replication fork//peroxisome//transcription factor complex KOG0735 AAA+-type ATPase Cluster-8309.57591 BP_3 53.51 0.76 3701 642929042 XP_973795.3 1220 8.2e-131 PREDICTED: homeobox protein Nkx-2.1-like [Tribolium castaneum] 736214483 XM_010779878.1 99 1.55365e-41 PREDICTED: Notothenia coriiceps NK2 homeobox 4 (nkx2-4), transcript variant X2, mRNA K09342 NKX2-1, TITF1 homeobox protein Nkx-2.1 http://www.genome.jp/dbget-bin/www_bget?ko:K09342 P23441 388 1.0e-35 Homeobox protein Nkx-2.1 OS=Rattus norvegicus GN=Nkx2-1 PE=1 SV=1 PF13374//PF00046 Tetratricopeptide repeat//Homeobox domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain Cluster-8309.57593 BP_3 3.00 1.42 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57594 BP_3 69.60 0.82 4403 642926332 XP_968832.2 2936 0.0e+00 PREDICTED: RING finger protein 207 isoform X2 [Tribolium castaneum] 642926333 XM_008196659.1 246 3.55313e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 670 2.4e-68 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF16685//PF04673//PF13639//PF04513//PF04728//PF06005//PF00097//PF14634//PF00643 zinc RING finger of MSL2//Polyketide synthesis cyclase//Ring finger domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Lipoprotein leucine-zipper//Protein of unknown function (DUF904)//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//B-box zinc finger GO:0043093//GO:0000917//GO:0030639 FtsZ-dependent cytokinesis//barrier septum assembly//polyketide biosynthetic process GO:0008270//GO:0046872//GO:0005198//GO:0061630//GO:0005515 zinc ion binding//metal ion binding//structural molecule activity//ubiquitin protein ligase activity//protein binding GO:0005622//GO:0005737//GO:0019028//GO:0019867//GO:0019031 intracellular//cytoplasm//viral capsid//outer membrane//viral envelope -- -- Cluster-8309.57595 BP_3 78.63 1.18 3496 642926330 XP_008194880.1 3517 0.0e+00 PREDICTED: RING finger protein 207 isoform X1 [Tribolium castaneum]>gi|270008488|gb|EFA04936.1| hypothetical protein TcasGA2_TC015003 [Tribolium castaneum] 642926333 XM_008196659.1 246 2.81517e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 938 1.6e-99 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF04513//PF04673//PF13639//PF06005//PF14634//PF00643//PF00097 Baculovirus polyhedron envelope protein, PEP, C terminus//Polyketide synthesis cyclase//Ring finger domain//Protein of unknown function (DUF904)//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0030639//GO:0043093//GO:0000917 polyketide biosynthetic process//FtsZ-dependent cytokinesis//barrier septum assembly GO:0005515//GO:0005198//GO:0008270//GO:0046872 protein binding//structural molecule activity//zinc ion binding//metal ion binding GO:0019028//GO:0019031//GO:0005622//GO:0005737 viral capsid//viral envelope//intracellular//cytoplasm -- -- Cluster-8309.57596 BP_3 10.76 0.53 1277 531446199 AGT57842.1 1034 1.0e-109 cytochrome P450 302a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10721 DIB CYP302A1; ecdysteroid 22-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10721 Q9NGX9 627 6.7e-64 Cytochrome P450 302a1, mitochondrial OS=Drosophila melanogaster GN=dib PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.57598 BP_3 91.14 4.78 1210 531446199 AGT57842.1 1456 1.2e-158 cytochrome P450 302a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10721 DIB CYP302A1; ecdysteroid 22-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10721 Q9NGX9 904 4.8e-96 Cytochrome P450 302a1, mitochondrial OS=Drosophila melanogaster GN=dib PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.57602 BP_3 24.60 2.31 805 759082852 XP_011351320.1 451 2.6e-42 PREDICTED: delta-aminolevulinic acid dehydratase [Cerapachys biroi]>gi|759082854|ref|XP_011351321.1| PREDICTED: delta-aminolevulinic acid dehydratase [Cerapachys biroi]>gi|607347768|gb|EZA46379.1| Delta-aminolevulinic acid dehydratase [Cerapachys biroi] -- -- -- -- -- K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 430 3.0e-41 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF00490 Delta-aminolevulinic acid dehydratase GO:0033014//GO:0015994 tetrapyrrole biosynthetic process//chlorophyll metabolic process GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding -- -- KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.57604 BP_3 627.00 3.22 9681 642936015 XP_008198269.1 2544 6.4e-284 PREDICTED: histone-lysine N-methyltransferase NSD2 [Tribolium castaneum]>gi|270014006|gb|EFA10454.1| hypothetical protein TcasGA2_TC012700 [Tribolium castaneum] -- -- -- -- -- K15588 NSD1 histone-lysine N-methyltransferase NSD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15588 O88491 1591 8.4e-175 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific OS=Mus musculus GN=Nsd1 PE=1 SV=1 PF08198//PF15184//PF00628//PF00439//PF03137//PF00856 Thymopoietin protein//Mitochondrial import receptor subunit TOM6 homolog//PHD-finger//Bromodomain//Organic Anion Transporter Polypeptide (OATP) family//SET domain GO:0032259//GO:0006810 methylation//transport GO:0043169//GO:0008168//GO:0003677//GO:0005515//GO:0005215 cation binding//methyltransferase activity//DNA binding//protein binding//transporter activity GO:0016020//GO:0005742 membrane//mitochondrial outer membrane translocase complex KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.57611 BP_3 130.09 4.67 1633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57612 BP_3 27.15 0.91 1729 478257733 ENN77876.1 1120 1.5e-119 hypothetical protein YQE_05554, partial [Dendroctonus ponderosae]>gi|546687636|gb|ERL96238.1| hypothetical protein D910_01526 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57614 BP_3 1.00 0.54 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57615 BP_3 92.08 1.00 4726 752866884 XP_011250445.1 2335 5.4e-260 PREDICTED: SCAN domain-containing protein 3-like [Camponotus floridanus] 751233256 XM_011171998.1 377 0 PREDICTED: Solenopsis invicta zinc finger BED domain-containing protein 5-like (LOC105203223), mRNA -- -- -- -- Q6R2W3 816 3.0e-85 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 PF05699//PF02892//PF06305 hAT family C-terminal dimerisation region//BED zinc finger//Protein of unknown function (DUF1049) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.57623 BP_3 263.24 3.08 4412 642922778 XP_008193321.1 2493 2.4e-278 PREDICTED: transmembrane and TPR repeat-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 1418 4.4e-155 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13176//PF13414//PF13174//PF00515//PF13374//PF13181//PF02827 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG1124 FOG: TPR repeat Cluster-8309.57624 BP_3 60.40 0.69 4535 642922778 XP_008193321.1 2493 2.5e-278 PREDICTED: transmembrane and TPR repeat-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 1418 4.5e-155 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13174//PF13414//PF13176//PF02827//PF13374//PF13181//PF00515 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG1124 FOG: TPR repeat Cluster-8309.57629 BP_3 2171.66 35.29 3258 189242412 XP_001810435.1 145 3.2e-06 PREDICTED: glycine-rich cell wall structural protein 1.8 isoform X1 [Tribolium castaneum]>gi|270016263|gb|EFA12709.1| hypothetical protein TcasGA2_TC002343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57633 BP_3 238.66 4.18 3042 270010177 EFA06625.1 3083 0.0e+00 hypothetical protein TcasGA2_TC009544 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z3J2 2084 1.8e-232 UPF0505 protein C16orf62 OS=Homo sapiens GN=C16orf62 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3682 Predicted membrane protein (associated with esophageal cancer in humans) Cluster-8309.57634 BP_3 1.00 0.46 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57636 BP_3 178.97 3.08 3088 795013623 XP_011883597.1 900 8.7e-94 PREDICTED: uncharacterized protein LOC105570767 isoform X2 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 135 1.8e-06 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.57639 BP_3 60.29 0.49 6163 91084751 XP_971582.1 1374 1.9e-148 PREDICTED: scavenger receptor class B member 1-like [Tribolium castaneum]>gi|642925852|ref|XP_008190558.1| PREDICTED: scavenger receptor class B member 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 447 2.4e-42 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130//PF08452 CD36 family//DNA polymerase family B exonuclease domain, N-terminal GO:0006260//GO:0007155 DNA replication//cell adhesion GO:0003887 DNA-directed DNA polymerase activity GO:0042575//GO:0016020 DNA polymerase complex//membrane -- -- Cluster-8309.57645 BP_3 29.32 0.65 2481 157887063 CAP09075.1 549 3.5e-53 minos transposase [Drosophila hydei] 572310349 XM_006620871.1 127 2.8233e-57 PREDICTED: Apis dorsata nuclear cap-binding protein subunit 2-like (LOC102673777), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 392 2.3e-36 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF08281//PF04218//PF01498//PF00076//PF04545//PF06056//PF00440//PF00292 Sigma-70, region 4//CENP-B N-terminal DNA-binding domain//Transposase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Sigma-70, region 4//Putative ATPase subunit of terminase (gpP-like)//Bacterial regulatory proteins, tetR family//'Paired box' domain GO:0006352//GO:0019069//GO:0015074//GO:0006355//GO:0006313 DNA-templated transcription, initiation//viral capsid assembly//DNA integration//regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0003700//GO:0016987//GO:0003676//GO:0005524//GO:0003677 transcription factor activity, sequence-specific DNA binding//sigma factor activity//nucleic acid binding//ATP binding//DNA binding GO:0005667 transcription factor complex KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.57648 BP_3 16.04 0.78 1285 478253800 ENN74092.1 411 1.8e-37 hypothetical protein YQE_09065, partial [Dendroctonus ponderosae] -- -- -- -- -- K13164 MSL2 male-specific lethal 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13164 Q9HCI7 203 9.9e-15 E3 ubiquitin-protein ligase MSL2 OS=Homo sapiens GN=MSL2 PE=1 SV=2 PF00706 Anenome neurotoxin GO:0009966 regulation of signal transduction -- -- GO:0005576 extracellular region -- -- Cluster-8309.57650 BP_3 69.22 1.93 2024 478253800 ENN74092.1 1231 2.4e-132 hypothetical protein YQE_09065, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q69ZF8 317 9.4e-28 E3 ubiquitin-protein ligase MSL2 OS=Mus musculus GN=Msl2 PE=2 SV=2 PF00706//PF16685 Anenome neurotoxin//zinc RING finger of MSL2 GO:0009966 regulation of signal transduction GO:0061630 ubiquitin protein ligase activity GO:0005576 extracellular region -- -- Cluster-8309.57652 BP_3 30.08 1.44 1300 844837396 XP_012792468.1 207 8.4e-14 Chromobox protein 8 [Schistosoma haematobium]>gi|685956510|gb|KGB32687.1| Chromobox protein 8 [Schistosoma haematobium] -- -- -- -- -- K11455 CBX8, PC3 chromobox protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11455 Q9HC52 162 5.7e-10 Chromobox protein homolog 8 OS=Homo sapiens GN=CBX8 PE=1 SV=3 PF06524//PF01552 NOA36 protein//Picornavirus 2B protein GO:0006508//GO:0006144//GO:0018144 proteolysis//purine nucleobase metabolic process//RNA-protein covalent cross-linking GO:0016779//GO:0008233//GO:0008234//GO:0008270//GO:0000166//GO:0003968//GO:0005198//GO:0016740//GO:0016787 nucleotidyltransferase activity//peptidase activity//cysteine-type peptidase activity//zinc ion binding//nucleotide binding//RNA-directed RNA polymerase activity//structural molecule activity//transferase activity//hydrolase activity GO:0031379//GO:0019012//GO:0005634 RNA-directed RNA polymerase complex//virion//nucleus KOG2748 Uncharacterized conserved protein, contains chromo domain Cluster-8309.57653 BP_3 7.00 0.33 1300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.57660 BP_3 26.18 0.56 2540 158294276 XP_001688670.1 369 2.7e-32 AGAP005507-PB [Anopheles gambiae str. PEST]>gi|158294278|ref|XP_001688671.1| AGAP005507-PA [Anopheles gambiae str. PEST]>gi|157015489|gb|EDO63676.1| AGAP005507-PB [Anopheles gambiae str. PEST]>gi|157015490|gb|EDO63677.1| AGAP005507-PA [Anopheles gambiae str. PEST] 768430547 XM_011558205.1 125 3.74026e-56 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105387473), transcript variant X3, mRNA >gnl|BL_ORD_ID|28135220 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105389571), transcript variant X3, mRNA K13504 VAMP2 vesicle-associated membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13504 P47194 284 7.9e-24 Synaptobrevin OS=Doryteuthis pealeii PE=1 SV=1 PF00957//PF04799//PF00517//PF15461 Synaptobrevin//fzo-like conserved region//Retroviral envelope protein//Beta-carotene 15,15'-dioxygenase GO:0055114//GO:0008053//GO:0016192 oxidation-reduction process//mitochondrial fusion//vesicle-mediated transport GO:0003924//GO:0016702//GO:0005198 GTPase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//structural molecule activity GO:0005741//GO:0019031//GO:0016021 mitochondrial outer membrane//viral envelope//integral component of membrane KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.57661 BP_3 5.00 3.34 360 158294276 XP_001688670.1 230 5.0e-17 AGAP005507-PB [Anopheles gambiae str. PEST]>gi|158294278|ref|XP_001688671.1| AGAP005507-PA [Anopheles gambiae str. PEST]>gi|157015489|gb|EDO63676.1| AGAP005507-PB [Anopheles gambiae str. PEST]>gi|157015490|gb|EDO63677.1| AGAP005507-PA [Anopheles gambiae str. PEST] 768437333 XM_011561901.1 69 6.5939e-26 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105390573), transcript variant X2, mRNA K13504 VAMP2 vesicle-associated membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13504 P47193 180 1.3e-12 Vesicle-associated membrane protein 2 OS=Xenopus laevis GN=vamp2 PE=3 SV=3 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.57662 BP_3 10.15 0.94 815 443682250 AGC97431.1 409 2.0e-37 ecdysone-induced protein 75-like protein, partial [Monochamus alternatus] 443682249 KC020244.1 189 3.08658e-92 Monochamus alternatus ecdysone-induced protein 75-like protein (E75) mRNA, partial cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 O77245 306 7.2e-27 Nuclear hormone receptor E75 OS=Metapenaeus ensis GN=E75 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57668 BP_3 5.47 1.27 499 270013658 EFA10106.1 252 1.9e-19 hypothetical protein TcasGA2_TC012285 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.57677 BP_3 8.20 0.43 1217 390362249 XP_001190749.2 311 6.8e-26 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q4UMH6 270 1.6e-22 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57683 BP_3 80.32 2.80 1672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-8309.57686 BP_3 285.79 5.09 2996 91089013 XP_968301.1 2664 2.4e-298 PREDICTED: RINT1-like protein [Tribolium castaneum]>gi|270011539|gb|EFA07987.1| hypothetical protein TcasGA2_TC005574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUQ1 1052 8.3e-113 RAD50-interacting protein 1 OS=Homo sapiens GN=RINT1 PE=1 SV=1 PF04437//PF08702//PF06008//PF05384 RINT-1 / TIP-1 family//Fibrinogen alpha/beta chain family//Laminin Domain I//Sensor protein DegS GO:0051258//GO:0048193//GO:0007165//GO:0030334//GO:0045995//GO:0030155//GO:0030168 protein polymerization//Golgi vesicle transport//signal transduction//regulation of cell migration//regulation of embryonic development//regulation of cell adhesion//platelet activation GO:0030674//GO:0005102//GO:0016301 protein binding, bridging//receptor binding//kinase activity GO:0005783//GO:0005577 endoplasmic reticulum//fibrinogen complex -- -- Cluster-8309.57687 BP_3 85.18 1.59 2878 91090768 XP_969213.1 982 2.5e-103 PREDICTED: protein artemis [Tribolium castaneum]>gi|270013270|gb|EFA09718.1| hypothetical protein TcasGA2_TC011851 [Tribolium castaneum] -- -- -- -- -- K10887 DCLRE1C, ARTEMIS, SCIDA DNA cross-link repair 1C protein http://www.genome.jp/dbget-bin/www_bget?ko:K10887 Q5QJC2 500 8.1e-49 Protein artemis OS=Gallus gallus GN=DCLRE1C PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1361 Predicted hydrolase involved in interstrand cross-link repair Cluster-8309.57691 BP_3 273.68 7.88 1966 642918258 XP_008191434.1 1452 5.5e-158 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918260|ref|XP_008191435.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918262|ref|XP_008191436.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 Q1HG43 346 4.0e-31 Dual oxidase maturation factor 1 OS=Homo sapiens GN=DUOXA1 PE=1 SV=1 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG3921 Uncharacterized conserved protein Cluster-8309.57692 BP_3 6.38 0.55 855 642916313 XP_008190970.1 384 1.6e-34 PREDICTED: mismatch repair endonuclease PMS2 [Tribolium castaneum] 687865299 LK927543.1 35 1.31613e-06 Caenorhabditis elegans genome assembly C_elegans_Bristol_N2_v1_5_4 ,scaffold CELN2_scaffold0000013 K10858 PMS2 DNA mismatch repair protein PMS2 http://www.genome.jp/dbget-bin/www_bget?ko:K10858 P54279 314 8.9e-28 Mismatch repair endonuclease PMS2 OS=Mus musculus GN=Pms2 PE=2 SV=1 PF02742//PF08676 Iron dependent repressor, metal binding and dimerisation domain//MutL C terminal dimerisation domain GO:0006298 mismatch repair GO:0046914//GO:0005524//GO:0046983 transition metal ion binding//ATP binding//protein dimerization activity -- -- KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family Cluster-8309.57694 BP_3 59.29 0.46 6517 478251276 ENN71747.1 1978 1.8e-218 hypothetical protein YQE_11567, partial [Dendroctonus ponderosae] -- -- -- -- -- K18164 NDUFAF7 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18164 Q5XI79 955 3.2e-101 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 OS=Rattus norvegicus GN=Ndufaf7 PE=2 SV=1 PF06814//PF10192 Lung seven transmembrane receptor//Rhodopsin-like GPCR transmembrane domain GO:0019236//GO:0007186 response to pheromone//G-protein coupled receptor signaling pathway -- -- GO:0016021 integral component of membrane KOG2901 Uncharacterized conserved protein Cluster-8309.57703 BP_3 106.69 0.87 6224 328712712 XP_003244886.1 2424 3.4e-270 PREDICTED: protein melted isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q9VS24 1151 5.7e-124 Protein melted OS=Drosophila melanogaster GN=melt PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3723 PH domain protein Melted Cluster-8309.57706 BP_3 8.89 0.41 1346 478254276 ENN74530.1 579 6.3e-57 hypothetical protein YQE_08854, partial [Dendroctonus ponderosae] -- -- -- -- -- K00566 mnmA, trmU, TRMU tRNA-specific 2-thiouridylase http://www.genome.jp/dbget-bin/www_bget?ko:K00566 Q503J2 457 3.7e-44 Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Danio rerio GN=trmu PE=2 SV=1 PF02568//PF00733 Thiamine biosynthesis protein (ThiI)//Asparagine synthase GO:0008033//GO:0006531//GO:0006522//GO:0006529 tRNA processing//aspartate metabolic process//alanine metabolic process//asparagine biosynthetic process GO:0004066//GO:0004810 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity -- -- KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Cluster-8309.57708 BP_3 2.07 0.35 580 270017242 EFA13688.1 249 5.0e-19 hypothetical protein TcasGA2_TC001594 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q8BSY0 206 2.0e-15 Aspartyl/asparaginyl beta-hydroxylase OS=Mus musculus GN=Asph PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3696 Aspartyl beta-hydroxylase Cluster-8309.57710 BP_3 137.10 7.15 1216 642919190 XP_008191775.1 910 2.4e-95 PREDICTED: RNA-binding protein 42 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66KL9 457 3.3e-44 RNA-binding protein 42 OS=Xenopus tropicalis GN=rbm42 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0226 RNA-binding proteins Cluster-8309.57712 BP_3 13.90 0.78 1155 478260157 ENN79935.1 502 4.6e-48 hypothetical protein YQE_03631, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AXT7 254 1.1e-20 RNA-binding protein 42 OS=Rattus norvegicus GN=Rbm42 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0226 RNA-binding proteins Cluster-8309.57713 BP_3 258.69 2.91 4573 642912407 XP_008199495.1 3247 0.0e+00 PREDICTED: liprin-alpha-1 isoform X13 [Tribolium castaneum] 642912406 XM_008201273.1 742 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X13, mRNA -- -- -- -- O75334 1539 4.3e-169 Liprin-alpha-2 OS=Homo sapiens GN=PPFIA2 PE=1 SV=2 PF05513//PF02459 TraA//Adenoviral DNA terminal protein GO:0000746//GO:0006260 conjugation//DNA replication GO:0003677 DNA binding GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.57718 BP_3 4.00 0.57 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57720 BP_3 29.52 0.83 2004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.57721 BP_3 3.16 0.74 497 332376240 AEE63260.1 298 9.0e-25 unknown [Dendroctonus ponderosae]>gi|478251203|gb|ENN71677.1| hypothetical protein YQE_11601, partial [Dendroctonus ponderosae]>gi|546676175|gb|ERL87242.1| hypothetical protein D910_04640 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O81884 140 7.7e-08 L-galactose dehydrogenase OS=Arabidopsis thaliana GN=LGALDH PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1576 Predicted oxidoreductase Cluster-8309.57723 BP_3 16.98 0.52 1876 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57724 BP_3 2.32 0.43 553 270012482 EFA08930.1 294 2.9e-24 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 181 1.5e-12 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.57726 BP_3 10.68 0.78 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57728 BP_3 4.00 0.97 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57729 BP_3 47.77 2.71 1141 642914619 XP_008190286.1 1110 1.4e-118 PREDICTED: Kv channel-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYN7 606 1.6e-61 Kv channel-interacting protein 4 OS=Macaca fascicularis GN=KCNIP4 PE=2 SV=1 PF13499//PF13405//PF10591//PF13833//PF12763//PF04434//PF00036//PF13202 EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//SWIM zinc finger//EF hand//EF hand GO:0007165 signal transduction GO:0008270//GO:0005509//GO:0005515 zinc ion binding//calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.5773 BP_3 2.00 0.48 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57730 BP_3 251.34 2.64 4881 242018392 XP_002429661.1 498 5.7e-47 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 383 5.1e-35 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF13465//PF00096//PF05279 Zinc-finger double domain//Zinc finger, C2H2 type//Aspartyl beta-hydroxylase N-terminal region -- -- GO:0046872 metal ion binding GO:0016020 membrane -- -- Cluster-8309.57733 BP_3 26.64 0.34 4048 91094617 XP_968941.1 1978 1.1e-218 PREDICTED: NEDD4-binding protein 2 [Tribolium castaneum]>gi|270016434|gb|EFA12880.1| hypothetical protein TcasGA2_TC011558 [Tribolium castaneum] -- -- -- -- -- K15720 N4BP2 NEDD4-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15720 Q92802 379 1.2e-34 NEDD4-binding protein 2-like 2 OS=Homo sapiens GN=N4BP2L2 PE=1 SV=1 PF02845//PF01234//PF06414 CUE domain//NNMT/PNMT/TEMT family//Zeta toxin -- -- GO:0008168//GO:0005524//GO:0016301//GO:0005515 methyltransferase activity//ATP binding//kinase activity//protein binding -- -- KOG2401 Predicted MutS-related protein involved in mismatch repair Cluster-8309.57737 BP_3 4.00 0.80 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57740 BP_3 3.00 0.34 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57741 BP_3 114.27 2.21 2788 642917584 XP_008191268.1 1727 1.0e-189 PREDICTED: peroxisome assembly factor 2 [Tribolium castaneum] 640815149 XM_008066140.1 77 1.97997e-29 PREDICTED: Tarsius syrichta peroxisomal biogenesis factor 6 (PEX6), transcript variant X2, mRNA K13339 PEX6, PXAAA1 peroxin-6 http://www.genome.jp/dbget-bin/www_bget?ko:K13339 Q13608 979 2.2e-104 Peroxisome assembly factor 2 OS=Homo sapiens GN=PEX6 PE=1 SV=2 PF02367//PF02562//PF07726//PF00910//PF00158//PF06068//PF01057//PF05496//PF07728//PF14532//PF01695//PF07724//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//RNA helicase//Sigma-54 interaction domain//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0006355//GO:0002949//GO:0019079//GO:0006281 DNA recombination//regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification//viral genome replication//DNA repair GO:0016887//GO:0003724//GO:0009378//GO:0003723//GO:0005524//GO:0003678//GO:0008134 ATPase activity//RNA helicase activity//four-way junction helicase activity//RNA binding//ATP binding//DNA helicase activity//transcription factor binding GO:0005657//GO:0009379//GO:0005667 replication fork//Holliday junction helicase complex//transcription factor complex KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain Cluster-8309.57743 BP_3 31.90 0.33 4984 642918959 XP_008191673.1 1817 6.6e-200 PREDICTED: NEDD8 ultimate buster 1-like [Tribolium castaneum]>gi|270005608|gb|EFA02056.1| hypothetical protein TcasGA2_TC007685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54729 611 1.9e-61 NEDD8 ultimate buster 1 OS=Mus musculus GN=Nub1 PE=1 SV=2 PF00240//PF13374//PF13414//PF03711//PF17050 Ubiquitin family//Tetratricopeptide repeat//TPR repeat//Orn/Lys/Arg decarboxylase, C-terminal domain//Altered inheritance of mitochondria 5 GO:0042407 cristae formation GO:0005515//GO:0003824 protein binding//catalytic activity GO:0044284//GO:0061617 mitochondrial crista junction//MICOS complex KOG2561 Adaptor protein NUB1, contains UBA domain Cluster-8309.57745 BP_3 13.96 1.36 786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57748 BP_3 77.65 2.65 1703 189235646 XP_968349.2 1801 1.6e-198 PREDICTED: peripheral plasma membrane protein CASK isoform X4 [Tribolium castaneum] 642917490 XM_963256.3 391 0 PREDICTED: Tribolium castaneum peripheral plasma membrane protein CASK (LOC656749), transcript variant X4, mRNA K06103 CASK calcium/calmodulin-dependent serine protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06103 Q24210 1267 5.5e-138 Peripheral plasma membrane protein CASK OS=Drosophila melanogaster GN=CASK PE=1 SV=4 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.57751 BP_3 14.21 1.28 826 478253905 ENN74197.1 363 4.3e-32 hypothetical protein YQE_09170, partial [Dendroctonus ponderosae] -- -- -- -- -- K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q8TAQ2 252 1.3e-20 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens GN=SMARCC2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57757 BP_3 49.54 1.51 1877 642917480 XP_008191219.1 606 6.6e-60 PREDICTED: probable RNA-binding protein 18 [Tribolium castaneum]>gi|270004407|gb|EFA00855.1| hypothetical protein TcasGA2_TC003758 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBM8 188 8.0e-13 Probable RNA-binding protein 18 OS=Danio rerio GN=rbm18 PE=2 SV=1 -- -- -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- -- -- Cluster-8309.57759 BP_3 10.12 0.77 924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57762 BP_3 30.73 0.56 2941 642921567 XP_008192427.1 3108 0.0e+00 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1547 3.2e-170 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF13374//PF02891//PF13181//PF00515//PF13176//PF06464//PF00637 Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//DMAP1-binding Domain//Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008134//GO:0005515//GO:0008270 transcription factor binding//protein binding//zinc ion binding GO:0005667//GO:0005634//GO:0005622 transcription factor complex//nucleus//intracellular KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.57763 BP_3 35.22 0.58 3212 642921567 XP_008192427.1 2340 9.6e-261 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1235 5.3e-134 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF00096//PF13181//PF00637//PF13176//PF06464//PF13374//PF02891//PF00515 Zinc finger, C2H2 type//Tetratricopeptide repeat//Region in Clathrin and VPS//Tetratricopeptide repeat//DMAP1-binding Domain//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0008134//GO:0046872//GO:0008270 protein binding//transcription factor binding//metal ion binding//zinc ion binding GO:0005667//GO:0005634//GO:0005622 transcription factor complex//nucleus//intracellular KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.57768 BP_3 3.00 1.43 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57769 BP_3 8.00 3.49 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57771 BP_3 109.86 1.87 3128 861625668 KMQ88610.1 201 1.0e-12 kda protein in nof-fb transposable element [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal GO:0008610 lipid biosynthetic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.57772 BP_3 2.00 0.62 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57773 BP_3 39.40 1.40 1644 189239358 XP_974445.2 1222 2.1e-131 PREDICTED: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [Tribolium castaneum] 817088660 XM_012411735.1 54 7.06858e-17 PREDICTED: Athalia rosae tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (LOC105692505), transcript variant X2, mRNA K05545 DUS4 tRNA-dihydrouridine synthase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05545 Q32M08 710 2.1e-73 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like OS=Mus musculus GN=Dus4l PE=2 SV=1 PF01207//PF00977 Dihydrouridine synthase (Dus)//Histidine biosynthesis protein GO:0000105//GO:0055114//GO:0008033 histidine biosynthetic process//oxidation-reduction process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.57774 BP_3 348.00 4.03 4459 861463488 XP_004855271.2 428 6.8e-39 PREDICTED: zinc finger protein 397 [Heterocephalus glaber] 641738213 XM_008161585.1 110 1.43922e-47 PREDICTED: Eptesicus fuscus zinc finger protein Gfi-1b (LOC103304778), transcript variant X2, mRNA >gnl|BL_ORD_ID|19479967 PREDICTED: Eptesicus fuscus zinc finger protein Gfi-1b (LOC103304819), transcript variant X2, mRNA K09223 GFI1 growth factor independent 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09223 Q05481 423 1.1e-39 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00096//PF00130//PF01155//PF02892//PF13912//PF01428 Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger GO:0035556//GO:0006464 intracellular signal transduction//cellular protein modification process GO:0016151//GO:0046872//GO:0008270//GO:0003677 nickel cation binding//metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.57779 BP_3 129.54 1.30 5088 189236066 XP_971573.2 1275 4.7e-137 PREDICTED: protein SMG9 [Tribolium castaneum] -- -- -- -- -- K18735 SMG9 protein SMG9 http://www.genome.jp/dbget-bin/www_bget?ko:K18735 Q05AW9 527 1.1e-51 Protein SMG9 OS=Xenopus laevis GN=smg9 PE=2 SV=1 PF03193//PF00005//PF09268//PF09726//PF01445//PF00071//PF00910//PF00931//PF08477//PF00735//PF10220//PF01926 Protein of unknown function, DUF258//ABC transporter//Clathrin, heavy-chain linker//Transmembrane protein//Viral small hydrophobic protein//Ras family//RNA helicase//NB-ARC domain//Ras of Complex, Roc, domain of DAPkinase//Septin//Uncharacterized conserved protein (DUF2146)//50S ribosome-binding GTPase GO:0007264//GO:0000184//GO:0006886//GO:0016192 small GTPase mediated signal transduction//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//intracellular protein transport//vesicle-mediated transport GO:0003724//GO:0005525//GO:0043531//GO:0003723//GO:0016887//GO:0003924//GO:0005198//GO:0005524 RNA helicase activity//GTP binding//ADP binding//RNA binding//ATPase activity//GTPase activity//structural molecule activity//ATP binding GO:0016020//GO:0030130//GO:0030132//GO:0016021 membrane//clathrin coat of trans-Golgi network vesicle//clathrin coat of coated pit//integral component of membrane KOG4181 Uncharacterized conserved protein Cluster-8309.5778 BP_3 4.30 0.39 822 642921037 XP_008192665.1 628 8.1e-63 PREDICTED: uncharacterized protein LOC103312818 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZL6 142 7.5e-08 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00617 RasGEF domain GO:0007264//GO:0043087 small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.57780 BP_3 2.00 7.19 274 642929346 XP_008195796.1 304 1.0e-25 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 [Tribolium castaneum]>gi|270009635|gb|EFA06083.1| hypothetical protein TcasGA2_TC008920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00993 Class II histocompatibility antigen, alpha domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0016020//GO:0042613 membrane//MHC class II protein complex -- -- Cluster-8309.57781 BP_3 11.00 0.65 1103 675369509 KFM62411.1 631 4.9e-63 Programmed cell death protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q61823 395 4.6e-37 Programmed cell death protein 4 OS=Mus musculus GN=Pdcd4 PE=1 SV=1 PF07989 Centrosomin N-terminal motif 1 -- -- -- -- GO:0005815 microtubule organizing center KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.57784 BP_3 498.58 12.15 2269 546677640 ERL88441.1 1731 2.8e-190 hypothetical protein D910_05827 [Dendroctonus ponderosae] -- -- -- -- -- K11214 SHPK sedoheptulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K11214 Q9D5J6 1023 1.4e-109 Sedoheptulokinase OS=Mus musculus GN=Shpk PE=1 SV=1 PF00370//PF01926 FGGY family of carbohydrate kinases, N-terminal domain//50S ribosome-binding GTPase GO:0005975 carbohydrate metabolic process GO:0016773//GO:0005525 phosphotransferase activity, alcohol group as acceptor//GTP binding -- -- -- -- Cluster-8309.57792 BP_3 4.73 0.38 891 642921311 XP_008192814.1 348 2.6e-30 PREDICTED: venom acid phosphatase Acph-1-like [Tribolium castaneum]>gi|270006249|gb|EFA02697.1| hypothetical protein TcasGA2_TC008419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLY5 198 2.6e-14 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57793 BP_3 135.34 2.62 2782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098 C2H2 zinc-finger//Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.57796 BP_3 12.28 0.54 1382 642939095 XP_008200219.1 1176 3.9e-126 PREDICTED: AH receptor-interacting protein [Tribolium castaneum]>gi|270016257|gb|EFA12703.1| hypothetical protein TcasGA2_TC002337 [Tribolium castaneum] -- -- -- -- -- K17767 AIP, XAP2 AH receptor-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17767 O00170 646 4.6e-66 AH receptor-interacting protein OS=Homo sapiens GN=AIP PE=1 SV=2 PF08631//PF13181//PF00515//PF00254//PF13414 Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//TPR repeat GO:0051321//GO:0006457 meiotic cell cycle//protein folding GO:0005515 protein binding -- -- KOG0545 Aryl-hydrocarbon receptor-interacting protein Cluster-8309.57799 BP_3 172.96 2.90 3169 619498812 AHY03304.1 537 1.1e-51 caspase-1 [Dastarcus helophoroides] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 512 3.6e-50 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.57800 BP_3 10.00 0.58 1120 546684536 ERL94167.1 217 5.0e-15 hypothetical protein D910_11449 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10483 Elongator subunit Iki1 -- -- -- -- GO:0033588 Elongator holoenzyme complex -- -- Cluster-8309.57801 BP_3 1.00 0.90 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57802 BP_3 2.00 0.33 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57806 BP_3 258.23 7.24 2011 642911217 XP_008199631.1 1556 4.9e-170 PREDICTED: FCH domain only protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502I9 648 3.9e-66 F-BAR domain only protein 2 OS=Danio rerio GN=fcho2 PE=2 SV=1 PF02662 Methyl-viologen-reducing hydrogenase, delta subunit GO:0055114//GO:0015948 oxidation-reduction process//methanogenesis -- -- -- -- KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.57809 BP_3 3.00 1.42 392 546683356 ERL93178.1 289 7.8e-24 hypothetical protein D910_10475 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57813 BP_3 28.14 1.33 1311 270005418 EFA01866.1 141 3.8e-06 hypothetical protein TcasGA2_TC007471 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57814 BP_3 19.90 0.48 2296 270014783 EFA11231.1 440 1.4e-40 hypothetical protein TcasGA2_TC010763 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02140 Galactose binding lectin domain -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.5782 BP_3 5.00 0.46 819 478250393 ENN70888.1 503 2.5e-48 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 317 3.8e-28 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.57820 BP_3 152.55 1.55 5031 642935193 XP_008199686.1 2675 2.1e-299 PREDICTED: ATP-dependent RNA helicase abstrakt [Tribolium castaneum] 665786806 XM_008556015.1 412 0 PREDICTED: Microplitis demolitor ATP-dependent RNA helicase abstrakt (LOC103575994), mRNA K13116 DDX41, ABS ATP-dependent RNA helicase DDX41 http://www.genome.jp/dbget-bin/www_bget?ko:K13116 Q9V3C0 2220 5.1e-248 ATP-dependent RNA helicase abstrakt OS=Drosophila melanogaster GN=abs PE=1 SV=1 PF00270//PF01805//PF06862//PF04851//PF00098 DEAD/DEAH box helicase//Surp module//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//Type III restriction enzyme, res subunit//Zinc knuckle GO:0006396 RNA processing GO:0003723//GO:0005524//GO:0016787//GO:0003677//GO:0008270//GO:0003676 RNA binding//ATP binding//hydrolase activity//DNA binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0341 DEAD-box protein abstrakt Cluster-8309.57825 BP_3 3.00 0.41 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57826 BP_3 86.86 1.21 3759 270003335 EEZ99782.1 1451 1.4e-157 hypothetical protein TcasGA2_TC002561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ERD6 793 1.1e-82 Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Mus musculus GN=Ralgps2 PE=1 SV=2 PF05767//PF00617//PF04636 Poxvirus virion envelope protein A14//RasGEF domain//PA26 p53-induced protein (sestrin) GO:0007264//GO:1901031//GO:0043087 small GTPase mediated signal transduction//regulation of response to reactive oxygen species//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0019031//GO:0005634 viral envelope//nucleus KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.57828 BP_3 25.19 0.72 1988 755545949 XP_011242903.1 916 7.8e-96 PREDICTED: zinc finger protein 431-like, partial [Mus musculus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 875 1.8e-92 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF00940//PF00096//PF05864//PF07776//PF13465//PF04810//PF01020//PF13912//PF16622 DNA-dependent RNA polymerase//Zinc finger, C2H2 type//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Sec23/Sec24 zinc finger//Ribosomal L40e family//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006351//GO:0006412//GO:0006888//GO:0006144//GO:0006206//GO:0006886//GO:0042254 transcription, DNA-templated//translation//ER to Golgi vesicle-mediated transport//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//intracellular protein transport//ribosome biogenesis GO:0003677//GO:0046872//GO:0003899//GO:0008270//GO:0003735 DNA binding//metal ion binding//DNA-directed RNA polymerase activity//zinc ion binding//structural constituent of ribosome GO:0005634//GO:0030127//GO:0005840//GO:0005730 nucleus//COPII vesicle coat//ribosome//nucleolus -- -- Cluster-8309.5783 BP_3 10.00 2.30 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57832 BP_3 282.82 5.29 2871 478251160 ENN71636.1 2129 2.5e-236 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17001//PF01665//PF04843 Type III secretion basal body protein I, YscI, HrpB, PscI//Rotavirus non-structural protein NSP3//Herpesvirus tegument protein, N-terminal conserved region GO:0009306//GO:0006508 protein secretion//proteolysis GO:0008233//GO:0003723 peptidase activity//RNA binding -- -- -- -- Cluster-8309.57835 BP_3 99.07 0.59 8340 478251160 ENN71636.1 2129 7.3e-236 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843//PF10399//PF01665//PF17001 Herpesvirus tegument protein, N-terminal conserved region//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//Rotavirus non-structural protein NSP3//Type III secretion basal body protein I, YscI, HrpB, PscI GO:0006508//GO:0006118//GO:0015992//GO:0055114//GO:0006119//GO:0009306 proteolysis//obsolete electron transport//proton transport//oxidation-reduction process//oxidative phosphorylation//protein secretion GO:0008233//GO:0003723//GO:0008121 peptidase activity//RNA binding//ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.57838 BP_3 19.33 0.60 1850 642937642 XP_008198883.1 660 3.5e-66 PREDICTED: male-specific lethal 3 homolog [Tribolium castaneum] -- -- -- -- -- K18403 MSL3 male-specific lethal 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18403 Q8N5Y2 327 6.0e-29 Male-specific lethal 3 homolog OS=Homo sapiens GN=MSL3 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0005801//GO:0016020 cis-Golgi network//membrane KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.57839 BP_3 107.43 0.85 6400 91091764 XP_969311.1 2691 3.8e-301 PREDICTED: DNA polymerase theta [Tribolium castaneum]>gi|270001085|gb|EEZ97532.1| hypothetical protein TcasGA2_TC011380 [Tribolium castaneum] -- -- -- -- -- K02349 POLQ DNA polymerase theta http://www.genome.jp/dbget-bin/www_bget?ko:K02349 O18475 2148 1.4e-239 DNA polymerase theta OS=Drosophila melanogaster GN=mus308 PE=1 SV=1 PF00476//PF02344//PF00270//PF04851//PF03791//PF01612 DNA polymerase family A//Myc leucine zipper domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//KNOX2 domain//3'-5' exonuclease GO:0006260//GO:0006355//GO:0006139 DNA replication//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process GO:0003700//GO:0008408//GO:0003676//GO:0003887//GO:0003677//GO:0016787//GO:0004386//GO:0005524 transcription factor activity, sequence-specific DNA binding//3'-5' exonuclease activity//nucleic acid binding//DNA-directed DNA polymerase activity//DNA binding//hydrolase activity//helicase activity//ATP binding GO:0042575//GO:0005667//GO:0005634 DNA polymerase complex//transcription factor complex//nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.57840 BP_3 138.45 1.11 6282 91091764 XP_969311.1 2691 3.7e-301 PREDICTED: DNA polymerase theta [Tribolium castaneum]>gi|270001085|gb|EEZ97532.1| hypothetical protein TcasGA2_TC011380 [Tribolium castaneum] -- -- -- -- -- K02349 POLQ DNA polymerase theta http://www.genome.jp/dbget-bin/www_bget?ko:K02349 O18475 2161 4.4e-241 DNA polymerase theta OS=Drosophila melanogaster GN=mus308 PE=1 SV=1 PF01612//PF04851//PF03791//PF00270//PF00476 3'-5' exonuclease//Type III restriction enzyme, res subunit//KNOX2 domain//DEAD/DEAH box helicase//DNA polymerase family A GO:0006139//GO:0006260 nucleobase-containing compound metabolic process//DNA replication GO:0004386//GO:0005524//GO:0016787//GO:0003677//GO:0003887//GO:0008408//GO:0003676 helicase activity//ATP binding//hydrolase activity//DNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//nucleic acid binding GO:0005634//GO:0042575 nucleus//DNA polymerase complex KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.57842 BP_3 3.33 0.41 679 607360166 EZA54504.1 138 4.4e-06 hypothetical protein X777_05483 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57845 BP_3 371.34 6.28 3142 642918773 XP_008191578.1 3748 0.0e+00 PREDICTED: calpain-D-like isoform X2 [Tribolium castaneum] 194768179 XM_001966155.1 202 7.27939e-99 Drosophila ananassae GF19541 (Dana\GF19541), mRNA K08582 CAPN15 calpain-15 http://www.genome.jp/dbget-bin/www_bget?ko:K08582 P27398 2414 1.0e-270 Calpain-D OS=Drosophila melanogaster GN=sol PE=1 SV=2 PF00648//PF00641 Calpain family cysteine protease//Zn-finger in Ran binding protein and others GO:0006508 proteolysis GO:0004198//GO:0008270 calcium-dependent cysteine-type endopeptidase activity//zinc ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.57847 BP_3 2.00 2.97 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57848 BP_3 6.00 2.57 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5785 BP_3 30.25 0.55 2958 546685576 ERL95063.1 2528 1.4e-282 hypothetical protein D910_12333 [Dendroctonus ponderosae] 564241862 XM_006277680.1 37 3.61883e-07 PREDICTED: Alligator mississippiensis REV1, polymerase (DNA directed) (REV1), transcript variant X3, mRNA K03515 REV1 DNA repair protein REV1 http://www.genome.jp/dbget-bin/www_bget?ko:K03515 Q4KWZ7 1026 8.4e-110 DNA repair protein REV1 OS=Gallus gallus GN=REV1 PE=2 SV=1 PF00817//PF00961//PF11799 impB/mucB/samB family//LAGLIDADG endonuclease//impB/mucB/samB family C-terminal domain GO:0006281 DNA repair GO:0003684//GO:0004519 damaged DNA binding//endonuclease activity -- -- KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase Cluster-8309.57851 BP_3 25.00 0.41 3222 795020598 XP_011859977.1 1057 5.7e-112 PREDICTED: uncharacterized protein LOC105557368 [Vollenhovia emeryi] 60418501 AY789006.1 86 2.27606e-34 Diaprepes abbreviatus clone DP1-K3 microsatellite sequence -- -- -- -- P04323 423 7.7e-40 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF01527//PF04218//PF01498 Transposase//CENP-B N-terminal DNA-binding domain//Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-8309.57855 BP_3 6.80 0.31 1356 642932789 XP_008196985.1 332 2.8e-28 PREDICTED: fibroblast growth factor 1-like [Tribolium castaneum]>gi|270012810|gb|EFA09258.1| fibroblast growth factor 1 [Tribolium castaneum] -- -- -- -- -- K18496 FGF1 fibroblast growth factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18496 Q7SIF8 196 6.8e-14 Fibroblast growth factor 1 (Fragment) OS=Notophthalmus viridescens GN=fgf1 PE=1 SV=1 PF06268//PF00340//PF00167 Fascin domain//Interleukin-1 / 18//Fibroblast growth factor GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0051015//GO:0008083//GO:0030674 actin filament binding//growth factor activity//protein binding, bridging GO:0005615 extracellular space -- -- Cluster-8309.57857 BP_3 9.04 0.36 1500 189242442 XP_001807060.1 138 9.7e-06 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57858 BP_3 8.90 0.80 828 189239355 XP_974286.2 290 1.3e-23 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q5NVJ8 215 2.6e-16 ATP-dependent RNA helicase DDX1 OS=Pongo abelii GN=DDX1 PE=2 SV=1 -- -- -- -- GO:0003676//GO:0005524//GO:0008026 nucleic acid binding//ATP binding//ATP-dependent helicase activity -- -- KOG0349 Putative DEAD-box RNA helicase DDX1 Cluster-8309.57860 BP_3 107.40 4.57 1425 642924737 XP_008194418.1 987 3.3e-104 PREDICTED: protein-S-isoprenylcysteine O-methyltransferase [Tribolium castaneum]>gi|270006711|gb|EFA03159.1| hypothetical protein TcasGA2_TC013078 [Tribolium castaneum] 242016078 XM_002428618.1 45 6.14984e-12 Pediculus humanus corporis protein-S-isoprenylcysteine O-methyltransferase, putative, mRNA K00587 ICMT, STE14 protein-S-isoprenylcysteine O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00587 O12947 722 7.2e-75 Protein-S-isoprenylcysteine O-methyltransferase OS=Xenopus laevis GN=icmt PE=2 SV=1 PF00951//PF04140 Arterivirus GL envelope glycoprotein//Isoprenylcysteine carboxyl methyltransferase (ICMT) family GO:0006481//GO:0006479 C-terminal protein methylation//protein methylation GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0005783//GO:0019031//GO:0016021 endoplasmic reticulum//viral envelope//integral component of membrane KOG2628 Farnesyl cysteine-carboxyl methyltransferase Cluster-8309.57861 BP_3 9.57 0.31 1793 189239711 XP_966387.2 1286 8.8e-139 PREDICTED: carbohydrate sulfotransferase 11 [Tribolium castaneum]>gi|270009383|gb|EFA05831.1| hypothetical protein TcasGA2_TC008615 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P69478 291 8.6e-25 Carbohydrate sulfotransferase 11 OS=Rattus norvegicus GN=Chst11 PE=1 SV=1 PF00159//PF02954//PF03567 Pancreatic hormone peptide//Bacterial regulatory protein, Fis family//Sulfotransferase family GO:0007165 signal transduction GO:0008146//GO:0043565//GO:0005179 sulfotransferase activity//sequence-specific DNA binding//hormone activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.57864 BP_3 237.10 6.79 1975 91090228 XP_968551.1 523 2.9e-50 PREDICTED: uncharacterized protein LOC656965 [Tribolium castaneum]>gi|270013773|gb|EFA10221.1| hypothetical protein TcasGA2_TC012417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15761//PF12052//PF00642 Immortalisation up-regulated protein//Voltage gated calcium channel subunit beta domain 4Aa N terminal//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005488//GO:0005245//GO:0046872 binding//voltage-gated calcium channel activity//metal ion binding GO:0005634//GO:0005891 nucleus//voltage-gated calcium channel complex -- -- Cluster-8309.57867 BP_3 1.00 1.58 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57868 BP_3 18.86 0.36 2836 751200773 XP_011163921.1 200 1.2e-12 PREDICTED: uncharacterized protein LOC105198778 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05881//PF02205 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)//WH2 motif GO:0009214 cyclic nucleotide catabolic process GO:0004113//GO:0003779 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity//actin binding GO:0016020 membrane -- -- Cluster-8309.57869 BP_3 117.86 8.93 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57870 BP_3 15.00 1.37 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57871 BP_3 20.38 0.36 3057 751200773 XP_011163921.1 200 1.3e-12 PREDICTED: uncharacterized protein LOC105198778 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05881 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase) GO:0009214 cyclic nucleotide catabolic process GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity GO:0016020 membrane -- -- Cluster-8309.57872 BP_3 23.09 0.42 2935 751200773 XP_011163921.1 200 1.2e-12 PREDICTED: uncharacterized protein LOC105198778 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05881//PF02205 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)//WH2 motif GO:0009214 cyclic nucleotide catabolic process GO:0003779//GO:0004113 actin binding//2',3'-cyclic-nucleotide 3'-phosphodiesterase activity GO:0016020 membrane -- -- Cluster-8309.57873 BP_3 166.13 4.97 1904 641653677 XP_008178885.1 140 7.2e-06 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103308032 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205 WH2 motif -- -- GO:0003779 actin binding -- -- -- -- Cluster-8309.57874 BP_3 31.70 0.55 3070 751200773 XP_011163921.1 200 1.3e-12 PREDICTED: uncharacterized protein LOC105198778 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05881//PF02205 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)//WH2 motif GO:0009214 cyclic nucleotide catabolic process GO:0003779//GO:0004113 actin binding//2',3'-cyclic-nucleotide 3'-phosphodiesterase activity GO:0016020 membrane -- -- Cluster-8309.57875 BP_3 108.55 1.71 3353 751200773 XP_011163921.1 200 1.4e-12 PREDICTED: uncharacterized protein LOC105198778 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05881//PF02205 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)//WH2 motif GO:0009214 cyclic nucleotide catabolic process GO:0004113//GO:0003779 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity//actin binding GO:0016020 membrane -- -- Cluster-8309.57877 BP_3 26.56 0.48 2951 751200773 XP_011163921.1 200 1.2e-12 PREDICTED: uncharacterized protein LOC105198778 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05881//PF02205 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)//WH2 motif GO:0009214 cyclic nucleotide catabolic process GO:0003779//GO:0004113 actin binding//2',3'-cyclic-nucleotide 3'-phosphodiesterase activity GO:0016020 membrane -- -- Cluster-8309.57878 BP_3 49.51 0.48 5252 675368932 KFM61834.1 1755 1.1e-192 RNA-directed DNA polymerase from mobile element jockey, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q9NBX4 485 8.1e-47 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 PF00075//PF00098 RNase H//Zinc knuckle GO:0051252 regulation of RNA metabolic process GO:0004523//GO:0008270//GO:0003676 RNA-DNA hybrid ribonuclease activity//zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.57880 BP_3 15.19 0.64 1440 91077034 XP_967567.1 1008 1.2e-106 PREDICTED: cysteine and histidine-rich domain-containing protein [Tribolium castaneum]>gi|270001750|gb|EEZ98197.1| hypothetical protein TcasGA2_TC000627 [Tribolium castaneum] -- -- -- -- -- K16729 CHORDC1, CHP1 cysteine and histidine-rich domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16729 Q9VCC0 876 1.0e-92 Cysteine and histidine-rich domain-containing protein OS=Drosophila melanogaster GN=CHORD PE=1 SV=1 PF00779 BTK motif GO:0035556 intracellular signal transduction -- -- -- -- KOG1667 Zn2+-binding protein Melusin/RAR1, contains CHORD domain Cluster-8309.57881 BP_3 10745.43 2287.56 518 150416593 ABF60889.2 209 2.0e-14 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.57882 BP_3 24.27 1.68 990 478251178 ENN71654.1 884 2.0e-92 hypothetical protein YQE_11752, partial [Dendroctonus ponderosae] -- -- -- -- -- K18180 COA7, SELRC1, RESA1 cytochrome c oxidase assembly factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18180 Q9W5N0 708 2.1e-73 Cytochrome c oxidase assembly factor 7 homolog OS=Drosophila melanogaster GN=CG13865 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4014 Uncharacterized conserved protein (contains TPR repeat) Cluster-8309.57887 BP_3 38.39 0.51 3952 642925330 XP_008194509.1 2050 5.0e-227 PREDICTED: codanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CC12 895 1.7e-94 Codanin-1 OS=Mus musculus GN=Cdan1 PE=2 SV=2 PF12920 TcdA/TcdB pore forming domain GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.57888 BP_3 30.79 0.49 3304 642929595 XP_008195898.1 1187 4.9e-127 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 804 5.2e-84 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 PF08395//PF04721 7tm Chemosensory receptor//PNGase C-terminal domain, mannose-binding module PAW GO:0006516//GO:0050909 glycoprotein catabolic process//sensory perception of taste -- -- GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG0909 Peptide:N-glycanase Cluster-8309.57890 BP_3 38.00 9.05 494 -- -- -- -- -- 768311755 CP010983.1 389 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57892 BP_3 8.63 0.45 1218 546684929 ERL94511.1 151 2.4e-07 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.5790 BP_3 14.00 0.34 2306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57901 BP_3 8.92 1.10 683 780686718 XP_011698706.1 284 5.2e-23 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Wasmannia auropunctata] -- -- -- -- -- K13128 ZCCHC8 zinc finger CCHC domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13128 Q2PE14 235 1.0e-18 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57903 BP_3 6.77 0.53 906 91082901 XP_972219.1 315 1.8e-26 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Tribolium castaneum]>gi|270007610|gb|EFA04058.1| hypothetical protein TcasGA2_TC014291 [Tribolium castaneum] -- -- -- -- -- K13128 ZCCHC8 zinc finger CCHC domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13128 Q2PE14 266 3.5e-22 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2673 Uncharacterized conserved protein, contains PSP domain Cluster-8309.57904 BP_3 128.42 1.58 4217 91082901 XP_972219.1 678 6.6e-68 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Tribolium castaneum]>gi|270007610|gb|EFA04058.1| hypothetical protein TcasGA2_TC014291 [Tribolium castaneum] -- -- -- -- -- K13128 ZCCHC8 zinc finger CCHC domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13128 Q2PE14 531 3.0e-52 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2673 Uncharacterized conserved protein, contains PSP domain Cluster-8309.57906 BP_3 33.15 0.71 2553 642927507 XP_008195297.1 1361 2.5e-147 PREDICTED: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642927506 XM_008197075.1 429 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC661648), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57912 BP_3 14.00 2.07 617 642914489 XP_008201696.1 191 2.8e-12 PREDICTED: uncharacterized protein C6orf106 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57913 BP_3 7.00 0.42 1103 641664521 XP_008183038.1 442 4.0e-41 PREDICTED: uncharacterized protein LOC103309427 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57915 BP_3 11.65 2.03 568 769832343 XP_011641658.1 409 1.4e-37 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105430037 [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363//PF13639 FYVE zinc finger//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.57916 BP_3 10.77 0.48 1367 676472905 XP_009059642.1 332 2.8e-28 hypothetical protein LOTGIDRAFT_204313 [Lottia gigantea]>gi|556100932|gb|ESO89584.1| hypothetical protein LOTGIDRAFT_204313 [Lottia gigantea] -- -- -- -- -- K01304 E3.4.19.3, pcp pyroglutamyl-peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01304 Q76IC5 264 8.9e-22 Pyroglutamyl-peptidase 1 OS=Rattus norvegicus GN=Pgpep1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4755 Predicted pyroglutamyl peptidase Cluster-8309.57917 BP_3 30.49 0.67 2491 189237885 XP_975345.2 1591 5.3e-174 PREDICTED: conserved oligomeric Golgi complex subunit 4 [Tribolium castaneum]>gi|270006703|gb|EFA03151.1| hypothetical protein TcasGA2_TC013064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95TN4 1070 5.6e-115 Conserved oligomeric Golgi complex subunit 4 OS=Drosophila melanogaster GN=CG7456 PE=1 SV=1 PF04111//PF16740//PF00738//PF09177//PF00015//PF04799//PF07393//PF03233//PF06046 Autophagy protein Apg6//Spindle and kinetochore-associated protein 2//Polyhedrin//Syntaxin 6, N-terminal//Methyl-accepting chemotaxis protein (MCP) signalling domain//fzo-like conserved region//Exocyst complex component Sec10//Aphid transmission protein//Exocyst complex component Sec6 GO:0007165//GO:0006914//GO:0000090//GO:0007067//GO:0048278//GO:0051301//GO:0031110//GO:0007059//GO:0019089//GO:0048193//GO:0008053//GO:0006887 signal transduction//autophagy//mitotic anaphase//mitotic nuclear division//vesicle docking//cell division//regulation of microtubule polymerization or depolymerization//chromosome segregation//transmission of virus//Golgi vesicle transport//mitochondrial fusion//exocytosis GO:0005198//GO:0003924//GO:0008017//GO:0004871 structural molecule activity//GTPase activity//microtubule binding//signal transducer activity GO:0016021//GO:0045298//GO:0005737//GO:0005876//GO:0005741//GO:0000145//GO:0000940//GO:0016020 integral component of membrane//tubulin complex//cytoplasm//spindle microtubule//mitochondrial outer membrane//exocyst//condensed chromosome outer kinetochore//membrane KOG0412 Golgi transport complex COD1 protein Cluster-8309.57924 BP_3 4.00 0.76 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08997 Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0006118//GO:0015992//GO:0006119 obsolete electron transport//proton transport//oxidative phosphorylation GO:0009055//GO:0008121 electron carrier activity//ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.57926 BP_3 9.53 0.40 1437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57927 BP_3 12.75 0.96 929 270014079 EFA10527.1 506 1.3e-48 hypothetical protein TcasGA2_TC012779 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI00 145 3.8e-08 Protein FAM107B OS=Bos taurus GN=FAM107B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57930 BP_3 160.76 3.39 2577 189237985 XP_001812669.1 617 4.8e-61 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 2-like [Tribolium castaneum] 665814259 XM_008557510.1 37 3.1492e-07 PREDICTED: Microplitis demolitor biogenesis of lysosome-related organelles complex 1 subunit 2 (LOC103577036), transcript variant X2, mRNA K16750 BLOC1S2 biogenesis of lysosome-related organelles complex 1 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16750 Q9VTE0 378 1.0e-34 Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Drosophila melanogaster GN=blos2 PE=1 SV=2 PF06009//PF08653//PF08702 Laminin Domain II//DASH complex subunit Dam1//Fibrinogen alpha/beta chain family GO:0007165//GO:0051258//GO:0008608//GO:0007155//GO:0030168 signal transduction//protein polymerization//attachment of spindle microtubules to kinetochore//cell adhesion//platelet activation GO:0030674//GO:0005102 protein binding, bridging//receptor binding GO:0072686//GO:0042729//GO:0005577 mitotic spindle//DASH complex//fibrinogen complex KOG4559 Uncharacterized conserved protein Cluster-8309.57931 BP_3 95.24 1.86 2762 189237985 XP_001812669.1 617 5.1e-61 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 2-like [Tribolium castaneum] 665814259 XM_008557510.1 37 3.37609e-07 PREDICTED: Microplitis demolitor biogenesis of lysosome-related organelles complex 1 subunit 2 (LOC103577036), transcript variant X2, mRNA K16750 BLOC1S2 biogenesis of lysosome-related organelles complex 1 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16750 Q9VTE0 378 1.1e-34 Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Drosophila melanogaster GN=blos2 PE=1 SV=2 PF06009//PF08653//PF08702 Laminin Domain II//DASH complex subunit Dam1//Fibrinogen alpha/beta chain family GO:0030168//GO:0008608//GO:0007155//GO:0007165//GO:0051258 platelet activation//attachment of spindle microtubules to kinetochore//cell adhesion//signal transduction//protein polymerization GO:0005102//GO:0030674 receptor binding//protein binding, bridging GO:0042729//GO:0005577//GO:0072686 DASH complex//fibrinogen complex//mitotic spindle KOG4559 Uncharacterized conserved protein Cluster-8309.57936 BP_3 1.00 1.35 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57938 BP_3 2.00 0.31 607 241122586 XP_002403590.1 230 8.4e-17 NADH:ubiquinone oxidoreductase, NDUFC2/B14.5B subunit, putative [Ixodes scapularis]>gi|215493480|gb|EEC03121.1| NADH:ubiquinone oxidoreductase, NDUFC2/B14.5B subunit, putative [Ixodes scapularis] -- -- -- -- -- K03968 NDUFC2 NADH dehydrogenase (ubiquinone) 1 subunit C2 http://www.genome.jp/dbget-bin/www_bget?ko:K03968 -- -- -- -- PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0015992//GO:0006814//GO:0006744//GO:0006120 proton transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.5794 BP_3 2.00 0.91 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57940 BP_3 17.58 0.75 1419 645021685 XP_008207623.1 459 5.5e-43 PREDICTED: sodium channel protein Nach [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q9VL84 226 2.4e-17 Pickpocket protein 11 OS=Drosophila melanogaster GN=ppk11 PE=2 SV=2 PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.57942 BP_3 19.94 0.72 1622 642927136 XP_972282.2 246 3.1e-18 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NWM0 131 2.8e-06 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01494//PF07992//PF12831//PF01593//PF06100//PF05834//PF01266//PF01134 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//MCRA family//Lycopene cyclase protein//FAD dependent oxidoreductase//Glucose inhibited division protein A GO:0006631//GO:0016117//GO:0055114//GO:0008033 fatty acid metabolic process//carotenoid biosynthetic process//oxidation-reduction process//tRNA processing GO:0050660//GO:0016705//GO:0071949//GO:0050151//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oleate hydratase activity//oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.57948 BP_3 76.61 0.73 5363 270002310 EEZ98757.1 2852 0.0e+00 hypothetical protein TcasGA2_TC001321 [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 O43795 1264 3.9e-137 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF00063//PF06414//PF09293//PF00612//PF06017//PF00437 Myosin head (motor domain)//Zeta toxin//T4 RNase H, C terminal//IQ calmodulin-binding motif//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0016301//GO:0003774//GO:0003824//GO:0005524//GO:0003677//GO:0005515 kinase activity//motor activity//catalytic activity//ATP binding//DNA binding//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.57949 BP_3 4.00 0.93 499 270002310 EEZ98757.1 243 2.1e-18 hypothetical protein TcasGA2_TC001321 [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 -- -- -- -- PF06017 Unconventional myosin tail, actin- and lipid-binding -- -- GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.57950 BP_3 92.16 0.86 5465 270007698 EFA04146.1 651 1.2e-64 hypothetical protein TcasGA2_TC014390 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R0K2 151 4.5e-08 E3 ubiquitin-protein ligase TRIM31 OS=Mus musculus GN=Trim31 PE=1 SV=1 PF14634//PF15957//PF00097//PF11789//PF13639 zinc-RING finger domain//Commissureless//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Ring finger domain GO:0007411 axon guidance GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.57958 BP_3 44.75 0.50 4581 478257224 ENN77387.1 1354 2.9e-146 hypothetical protein YQE_06212, partial [Dendroctonus ponderosae] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM91 753 5.9e-78 Tubulin glycylase 3A OS=Drosophila melanogaster GN=TTLL3A PE=1 SV=1 PF00299//PF07525//PF03133 Squash family serine protease inhibitor//SOCS box//Tubulin-tyrosine ligase family GO:0006464//GO:0035556 cellular protein modification process//intracellular signal transduction GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.5796 BP_3 4.41 0.43 787 270008853 EFA05301.1 333 1.2e-28 hypothetical protein TcasGA2_TC015458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02969 TATA box binding protein associated factor (TAF) GO:0006352 DNA-templated transcription, initiation -- -- GO:0005634 nucleus KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.57961 BP_3 24.48 0.43 3033 546684923 ERL94505.1 1103 2.5e-117 hypothetical protein D910_11782 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NDM2 472 1.5e-45 Protein trapped in endoderm-1 OS=Drosophila melanogaster GN=Tre1 PE=1 SV=1 PF04114//PF05296//PF00001 Gaa1-like, GPI transamidase component//Taste receptor protein (TAS2R)//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0042765 integral component of membrane//GPI-anchor transamidase complex -- -- Cluster-8309.57963 BP_3 12.00 0.38 1819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.57968 BP_3 117.27 6.44 1170 640788486 XP_008050052.1 230 1.6e-16 PREDICTED: zinc finger protein 208-like, partial [Tarsius syrichta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q02525 210 1.4e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF13465//PF00096//PF01363//PF13912//PF06221//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//FYVE zinc finger//C2H2-type zinc finger//Putative zinc finger motif, C2HC5-type//Zinc-finger associated domain (zf-AD) GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.57969 BP_3 74.75 0.72 5273 642927466 XP_008195284.1 1228 1.4e-131 PREDICTED: protein arginine N-methyltransferase 6 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q14914 756 3.1e-78 Prostaglandin reductase 1 OS=Homo sapiens GN=PTGR1 PE=1 SV=2 PF01135//PF05175//PF01370//PF08241//PF02527//PF00208//PF03602//PF01118//PF09243//PF00107//PF05185//PF05401 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//NAD dependent epimerase/dehydratase family//Methyltransferase domain//rRNA small subunit methyltransferase G//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Conserved hypothetical protein 95//Semialdehyde dehydrogenase, NAD binding domain//Mitochondrial small ribosomal subunit Rsm22//Zinc-binding dehydrogenase//PRMT5 arginine-N-methyltransferase//Nodulation protein S (NodS) GO:0006412//GO:0008152//GO:0006520//GO:0046500//GO:0009877//GO:0006479//GO:0031167//GO:0006464//GO:0009312//GO:0055114//GO:0000154//GO:0006396//GO:0006364 translation//metabolic process//cellular amino acid metabolic process//S-adenosylmethionine metabolic process//nodulation//protein methylation//rRNA methylation//cellular protein modification process//oligosaccharide biosynthetic process//oxidation-reduction process//rRNA modification//RNA processing//rRNA processing GO:0051287//GO:0016491//GO:0008649//GO:0003824//GO:0008757//GO:0004719//GO:0050662//GO:0016620//GO:0008168 NAD binding//oxidoreductase activity//rRNA methyltransferase activity//catalytic activity//S-adenosylmethionine-dependent methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//coenzyme binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//methyltransferase activity GO:0005737 cytoplasm KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.5797 BP_3 3.00 0.38 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57973 BP_3 100.73 1.97 2757 795012910 XP_011880473.1 1507 3.2e-164 PREDICTED: uncharacterized protein LOC105568978 [Vollenhovia emeryi]>gi|795012913|ref|XP_011880481.1| PREDICTED: uncharacterized protein LOC105568978 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699//PF01480 hAT family C-terminal dimerisation region//PWI domain GO:0006397 mRNA processing GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.57977 BP_3 55.53 1.51 2064 642922521 XP_008193210.1 989 2.8e-104 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92845 356 2.9e-32 Kinesin-associated protein 3 OS=Homo sapiens GN=KIFAP3 PE=1 SV=2 PF00514 Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.57978 BP_3 3.99 0.54 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57981 BP_3 10.38 0.34 1774 26324131 AAN77377.1 2686 4.0e-301 smooth endoplasmic reticulum calcium ATPase [Porcellio scaber] 378947922 JN986572.1 799 0 Litopenaeus vannamei sarco/endoplasmic reticulum Ca2+-ATPase mRNA, complete cds K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 Q7PPA5 2496 1.8e-280 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Anopheles gambiae GN=Ca-P60A PE=3 SV=5 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.57992 BP_3 9.18 1.34 622 332374164 AEE62223.1 364 2.5e-32 unknown [Dendroctonus ponderosae] 821464696 XM_003759701.2 89 9.03436e-37 PREDICTED: Sarcophilus harrisii transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant X2, mRNA K03872 TCEB1 transcription elongation factor B, polypeptide 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03872 Q2KII4 316 3.8e-28 Transcription elongation factor B polypeptide 1 OS=Bos taurus GN=TCEB1 PE=3 SV=1 PF03931 Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process -- -- -- -- KOG3473 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin C Cluster-8309.580 BP_3 52.83 1.38 2133 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00220//PF14144 Neurohypophysial hormones, N-terminal Domain//Seed dormancy control GO:0006351//GO:0007218 transcription, DNA-templated//neuropeptide signaling pathway GO:0005185//GO:0043565 neurohypophyseal hormone activity//sequence-specific DNA binding GO:0005576 extracellular region -- -- Cluster-8309.58000 BP_3 228.44 4.39 2800 642914595 XP_008190278.1 1870 2.6e-206 PREDICTED: DNA topoisomerase 2-binding protein 1-B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q800K6 787 4.1e-82 DNA topoisomerase 2-binding protein 1-A OS=Xenopus laevis GN=topbp1-A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1929 Nucleotide excision repair factor NEF2, RAD4/CUT5 component Cluster-8309.58002 BP_3 97.50 1.68 3084 642915549 XP_008190662.1 721 5.0e-73 PREDICTED: RNA-binding protein 25 isoform X1 [Tribolium castaneum]>gi|270003846|gb|EFA00294.1| hypothetical protein TcasGA2_TC003127 [Tribolium castaneum] -- -- -- -- -- K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 306 2.7e-26 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076//PF10579 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Rapsyn N-terminal myristoylation and linker region GO:0006397//GO:0007268 mRNA processing//synaptic transmission GO:0000166//GO:0033130//GO:0003676//GO:0043495 nucleotide binding//acetylcholine receptor binding//nucleic acid binding//protein anchor -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.58004 BP_3 24.00 0.61 2183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58007 BP_3 73.12 0.66 5641 827556941 XP_012549781.1 1722 7.7e-189 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.58008 BP_3 80.25 0.52 7671 827556941 XP_012549781.1 1641 2.6e-179 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58017 BP_3 19.06 0.75 1518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58018 BP_3 112.26 2.15 2804 91092924 XP_971718.1 2353 2.6e-262 PREDICTED: dynein intermediate chain 3, ciliary [Tribolium castaneum]>gi|270003101|gb|EEZ99548.1| hypothetical protein TcasGA2_TC000130 [Tribolium castaneum] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 Q16960 1537 4.5e-169 Dynein intermediate chain 3, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.58019 BP_3 342.32 3.12 5575 189241146 XP_974291.2 4208 0.0e+00 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7C5 1701 8.5e-188 Phosphatidylinositide phosphatase SAC2 OS=Danio rerio GN=inpp5f PE=3 SV=1 PF06056//PF03092//PF02383 Putative ATPase subunit of terminase (gpP-like)//BT1 family//SacI homology domain GO:0019069//GO:0006810 viral capsid assembly//transport GO:0042578//GO:0005524 phosphoric ester hydrolase activity//ATP binding GO:0016021 integral component of membrane KOG1889 Putative phosphoinositide phosphatase Cluster-8309.5802 BP_3 3.00 0.37 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58025 BP_3 32.21 2.05 1050 189238464 XP_966906.2 645 1.1e-64 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q8CEC6 495 1.1e-48 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Mus musculus GN=Ppwd1 PE=2 SV=2 PF03661//PF00400 Uncharacterised protein family (UPF0121)//WD domain, G-beta repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.58026 BP_3 566.92 15.73 2029 270010956 EFA07404.1 926 5.5e-97 hypothetical protein TcasGA2_TC016387 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02667 143 1.4e-07 Adenosine receptor A3 OS=Oryctolagus cuniculus GN=ADORA3 PE=2 SV=1 PF00001//PF07127//PF00895 7 transmembrane receptor (rhodopsin family)//Late nodulin protein//ATP synthase protein 8 GO:0015992//GO:0015986//GO:0009878//GO:0007186 proton transport//ATP synthesis coupled proton transport//nodule morphogenesis//G-protein coupled receptor signaling pathway GO:0046872//GO:0015078//GO:0004930 metal ion binding//hydrogen ion transmembrane transporter activity//G-protein coupled receptor activity GO:0000276//GO:0016021 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.58029 BP_3 14.00 0.48 1710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58030 BP_3 363.77 11.35 1837 478257112 ENN77275.1 1264 3.2e-136 hypothetical protein YQE_06102, partial [Dendroctonus ponderosae]>gi|546683352|gb|ERL93174.1| hypothetical protein D910_10471 [Dendroctonus ponderosae] -- -- -- -- -- K11248 SH3GLB endophilin-B http://www.genome.jp/dbget-bin/www_bget?ko:K11248 Q5ZIR1 867 1.4e-91 Endophilin-B1 OS=Gallus gallus GN=SH3GLB1 PE=2 SV=1 PF14604//PF00018//PF03114 Variant SH3 domain//SH3 domain//BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG3725 SH3 domain protein SH3GLB Cluster-8309.58034 BP_3 281.90 6.29 2451 91089169 XP_974055.1 3256 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X1 [Tribolium castaneum] 642932798 XM_008198766.1 288 8.8306e-147 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1634 2.2e-180 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF00637//PF13639//PF14634//PF17123//PF17122//PF00097 Region in Clathrin and VPS//Ring finger domain//zinc-RING finger domain//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger) GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.58035 BP_3 24.00 0.62 2143 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58039 BP_3 108.10 4.78 1381 91078956 XP_974192.1 730 2.0e-74 PREDICTED: protein prune homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BIW1 423 3.3e-40 Protein prune homolog OS=Mus musculus GN=Prune PE=2 SV=1 PF02833 DHHA2 domain -- -- GO:0016462 pyrophosphatase activity GO:0005737 cytoplasm KOG4129 Exopolyphosphatases and related proteins Cluster-8309.58041 BP_3 8399.51 348.63 1453 148469568 ABQ65713.1 843 1.7e-87 encapsulation-relating protein variant a [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.58043 BP_3 65.01 0.82 4097 189241960 XP_968710.2 2559 4.9e-286 PREDICTED: rho guanine nucleotide exchange factor 9 isoform X2 [Tribolium castaneum] 805759873 XM_012297744.1 247 9.1868e-124 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 1.7e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.58044 BP_3 352.00 2.83 6286 642939177 XP_969952.3 5007 0.0e+00 PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3 [Tribolium castaneum] 642939172 XM_008202143.1 79 3.47449e-30 PREDICTED: Tribolium castaneum uncharacterized LOC103314901 (LOC103314901), transcript variant X1, mRNA K05316 CACNA2DN voltage-dependent calcium channel alpha-2/delta, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05316 Q7Z3S7 1454 4.2e-159 Voltage-dependent calcium channel subunit alpha-2/delta-4 OS=Homo sapiens GN=CACNA2D4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.58047 BP_3 47.00 2.94 1063 768441273 XP_011562353.1 287 3.6e-23 PREDICTED: scavenger receptor class B member 1 isoform X1 [Plutella xylostella] 826494758 XM_012685372.1 90 4.3958e-37 PREDICTED: Monomorium pharaonis scavenger receptor class B member 1 (LOC105839216), mRNA -- -- -- -- -- -- -- -- PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.58049 BP_3 32.51 0.44 3846 642929562 XP_008195885.1 2972 0.0e+00 PREDICTED: ankyrin repeat and IBR domain-containing protein 1-like [Tribolium castaneum]>gi|270010556|gb|EFA07004.1| hypothetical protein TcasGA2_TC009974 [Tribolium castaneum] -- -- -- -- -- K11967 ANKIB1 ankyrin repeat and IBR domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11967 Q6ZPS6 1662 2.0e-183 Ankyrin repeat and IBR domain-containing protein 1 OS=Mus musculus GN=Ankib1 PE=1 SV=2 PF13606//PF14634//PF00023//PF00097//PF13639 Ankyrin repeat//zinc-RING finger domain//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.58050 BP_3 33.00 0.69 2612 270002008 EEZ98455.1 2345 2.0e-261 hypothetical protein TcasGA2_TC000945 [Tribolium castaneum] 642913296 XM_970406.2 606 0 PREDICTED: Tribolium castaneum vesicular acetylcholine transporter (LOC664399), mRNA K14636 SLC18A3, VACHT MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14636 O17444 1915 6.1e-213 Vesicular acetylcholine transporter OS=Drosophila melanogaster GN=VAChT PE=2 SV=2 PF07690//PF09905 Major Facilitator Superfamily//Uncharacterized conserved protein (DUF2132) GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0016021 integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.58054 BP_3 3.00 0.44 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58055 BP_3 7.26 0.53 949 91081441 XP_973723.1 178 1.4e-10 PREDICTED: transmembrane protein 184C [Tribolium castaneum]>gi|270006131|gb|EFA02579.1| hypothetical protein TcasGA2_TC008297 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58060 BP_3 170.62 1.16 7382 546684778 ERL94373.1 3144 0.0e+00 hypothetical protein D910_11653 [Dendroctonus ponderosae] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 1730 4.9e-191 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF05148//PF00270//PF10391//PF05206//PF08241//PF05175 Hypothetical methyltransferase//DEAD/DEAH box helicase//Fingers domain of DNA polymerase lambda//Methyltransferase TRM13//Methyltransferase domain//Methyltransferase small domain GO:0008033//GO:0008152 tRNA processing//metabolic process GO:0008168//GO:0003676//GO:0034061//GO:0005524//GO:0003677 methyltransferase activity//nucleic acid binding//DNA polymerase activity//ATP binding//DNA binding GO:0005634 nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.58063 BP_3 8.00 0.38 1304 642929553 XP_008195882.1 160 2.4e-08 PREDICTED: DNA excision repair protein ERCC-6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58068 BP_3 9.00 0.44 1280 34099638 AAQ57129.1 676 3.4e-68 endonuclease and reverse transcriptase-like protein [Bombyx mori] 299560965 GU183031.1 78 2.49126e-30 Scylla paramamosain microsatellite A340 sequence -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.58069 BP_3 2.00 0.36 560 21617525 AAM66719.1 296 1.7e-24 larval cuticle protein 12.6 [Apriona germari] -- -- -- -- -- -- -- -- -- O02388 217 1.0e-16 Larval cuticle protein LCP-22 OS=Bombyx mori GN=LCP22 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.58070 BP_3 20.13 0.70 1687 478267740 ENN83098.1 409 4.1e-37 hypothetical protein YQE_00541, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BN95 185 1.6e-12 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58071 BP_3 57.00 4.31 929 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58072 BP_3 11.89 0.58 1272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58073 BP_3 7.00 0.44 1062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58083 BP_3 164.08 1.11 7393 823393575 XP_012411540.1 776 5.0e-79 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like [Trichechus manatus latirostris] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 728 7.6e-75 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF01040//PF00096//PF00867//PF06814//PF07776//PF06467//PF00752//PF13465//PF02892//PF13912 UbiA prenyltransferase family//Zinc finger, C2H2 type//XPG I-region//Lung seven transmembrane receptor//Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//XPG N-terminal domain//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger GO:0006281 DNA repair GO:0003677//GO:0004659//GO:0008270//GO:0046872//GO:0004518 DNA binding//prenyltransferase activity//zinc ion binding//metal ion binding//nuclease activity GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.58089 BP_3 53.84 0.70 3977 270010437 EFA06885.1 2442 1.8e-272 hypothetical protein TcasGA2_TC009830 [Tribolium castaneum] 827546919 XM_004926175.2 138 3.49063e-63 PREDICTED: Bombyx mori protein prickle-like (LOC101737057), mRNA K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 A1Z6W3 1454 2.7e-159 Protein prickle OS=Drosophila melanogaster GN=pk PE=1 SV=1 PF01777//PF06297//PF00412//PF02529 Ribosomal L27e protein family//PET Domain//LIM domain//Cytochrome B6-F complex subunit 5 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0008270 structural constituent of ribosome//zinc ion binding GO:0005622//GO:0009512//GO:0005840 intracellular//cytochrome b6f complex//ribosome KOG1704 FOG: LIM domain Cluster-8309.58096 BP_3 4.43 0.42 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58098 BP_3 6701.24 3355.39 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58099 BP_3 76.92 6.49 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58100 BP_3 8172.95 637.16 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58101 BP_3 29.74 1.83 1076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58105 BP_3 278.21 6.15 2473 642910743 XP_008193390.1 2580 1.1e-288 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror2 [Tribolium castaneum]>gi|270015023|gb|EFA11471.1| hypothetical protein TcasGA2_TC014181 [Tribolium castaneum] 780671162 XM_011696978.1 111 2.2064e-48 PREDICTED: Wasmannia auropunctata tyrosine-protein kinase transmembrane receptor Ror2 (LOC105454395), mRNA K05129 MUSK muscle, skeletal, receptor tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05129 Q8AXY6 1530 2.6e-168 Muscle, skeletal receptor tyrosine protein kinase OS=Gallus gallus GN=MUSK PE=2 SV=1 PF07714//PF00069//PF01392 Protein tyrosine kinase//Protein kinase domain//Fz domain GO:0006468 protein phosphorylation GO:0004713//GO:0005524//GO:0004672//GO:0005515 protein tyrosine kinase activity//ATP binding//protein kinase activity//protein binding -- -- -- -- Cluster-8309.58107 BP_3 2.00 0.63 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58108 BP_3 57.82 4.75 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58110 BP_3 274.73 3.22 4399 270012898 EFA09346.1 2263 1.1e-251 hypothetical protein TcasGA2_TC001672 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q64425 822 5.7e-86 Pancreatic triacylglycerol lipase (Fragment) OS=Myocastor coypus GN=PNLIP PE=2 SV=1 PF08240//PF00107//PF01764 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase//Lipase (class 3) GO:0006629//GO:0055114 lipid metabolic process//oxidation-reduction process -- -- -- -- -- -- Cluster-8309.58111 BP_3 13.73 0.76 1161 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58116 BP_3 9.47 0.34 1634 546679816 ERL90208.1 541 2.0e-52 hypothetical protein D910_07562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 459 2.6e-44 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664 ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.58117 BP_3 63764.00 5061.03 899 -- -- -- -- -- 156553235 XM_001599402.1 95 6.1398e-40 PREDICTED: Nasonia vitripennis histidine-rich glycoprotein (LOC100114425), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58120 BP_3 1.00 23.78 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58124 BP_3 14.29 1.63 715 642923877 XP_008193910.1 671 7.2e-68 PREDICTED: aristaless isoform X1 [Tribolium castaneum] 543718138 XM_005500258.1 59 4.9725e-20 PREDICTED: Columba livia ALX homeobox 4 (ALX4), mRNA K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 Q06453 405 2.1e-38 Homeobox protein aristaless OS=Drosophila melanogaster GN=al PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.58127 BP_3 358.78 3.73 4934 478260655 ENN80352.1 1748 6.5e-192 hypothetical protein YQE_03211, partial [Dendroctonus ponderosae]>gi|546683687|gb|ERL93465.1| hypothetical protein D910_10756 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R5M3 241 1.5e-18 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF07473//PF13855//PF00560 Spasmodic peptide gm9a; conotoxin from Conus species//Leucine rich repeat//Leucine Rich Repeat GO:0009405 pathogenesis GO:0005515 protein binding GO:0005576 extracellular region -- -- Cluster-8309.58132 BP_3 300.64 3.12 4934 642923713 XP_008193853.1 5559 0.0e+00 PREDICTED: neuralized-like protein 4 [Tribolium castaneum] -- -- -- -- -- K16777 NEURL4 neuralized-like protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16777 A1L0Y2 2571 9.9e-289 Neuralized-like protein 4 OS=Xenopus tropicalis GN=neurl4 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.58134 BP_3 113.45 1.77 3378 642923713 XP_008193853.1 4088 0.0e+00 PREDICTED: neuralized-like protein 4 [Tribolium castaneum] -- -- -- -- -- K16777 NEURL4 neuralized-like protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16777 A1L0Y2 2083 2.6e-232 Neuralized-like protein 4 OS=Xenopus tropicalis GN=neurl4 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.58136 BP_3 8.61 0.33 1549 270001464 EEZ97911.1 1060 1.2e-112 hypothetical protein TcasGA2_TC000296 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYN7 608 1.3e-61 Kv channel-interacting protein 4 OS=Macaca fascicularis GN=KCNIP4 PE=2 SV=1 PF13202//PF00036//PF04434//PF12763//PF13499//PF13833//PF10591//PF13405 EF hand//EF hand//SWIM zinc finger//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain GO:0007165 signal transduction GO:0005515//GO:0005509//GO:0008270 protein binding//calcium ion binding//zinc ion binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.58137 BP_3 13.00 0.65 1257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58138 BP_3 13.00 1.30 774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58146 BP_3 62.00 4.81 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58147 BP_3 8.00 0.39 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58149 BP_3 32.56 1.25 1550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58156 BP_3 178.62 1.78 5135 478253546 ENN73864.1 968 1.9e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.88179e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 9.9e-82 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF01529//PF06814 Peptidase family M50//DHHC palmitoyltransferase//Lung seven transmembrane receptor GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG2585 Uncharacterized conserved protein Cluster-8309.58163 BP_3 20.38 0.36 2996 91092924 XP_971718.1 2353 2.8e-262 PREDICTED: dynein intermediate chain 3, ciliary [Tribolium castaneum]>gi|270003101|gb|EEZ99548.1| hypothetical protein TcasGA2_TC000130 [Tribolium castaneum] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 Q16960 1537 4.8e-169 Dynein intermediate chain 3, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.58164 BP_3 20.54 0.39 2855 91092924 XP_971718.1 2353 2.6e-262 PREDICTED: dynein intermediate chain 3, ciliary [Tribolium castaneum]>gi|270003101|gb|EEZ99548.1| hypothetical protein TcasGA2_TC000130 [Tribolium castaneum] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 Q16960 1537 4.5e-169 Dynein intermediate chain 3, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF00213//PF00400 ATP synthase delta (OSCP) subunit//WD domain, G-beta repeat GO:0015986 ATP synthesis coupled proton transport GO:0046933//GO:0005515 proton-transporting ATP synthase activity, rotational mechanism//protein binding GO:0045259 proton-transporting ATP synthase complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.58165 BP_3 62.54 1.12 2975 91092924 XP_971718.1 1838 1.4e-202 PREDICTED: dynein intermediate chain 3, ciliary [Tribolium castaneum]>gi|270003101|gb|EEZ99548.1| hypothetical protein TcasGA2_TC000130 [Tribolium castaneum] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 Q16960 1245 3.4e-135 Dynein intermediate chain 3, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.58166 BP_3 80.93 1.39 3089 478250954 ENN71438.1 1093 3.6e-116 hypothetical protein YQE_11857, partial [Dendroctonus ponderosae]>gi|546682677|gb|ERL92589.1| hypothetical protein D910_09902 [Dendroctonus ponderosae] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 Q9GZS0 761 4.7e-79 Dynein intermediate chain 2, axonemal OS=Homo sapiens GN=DNAI2 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.58167 BP_3 2.00 18.72 245 -- -- -- -- -- 525346489 KC793960.1 78 4.24481e-31 Scylla paramamosain clone Scpa68 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58168 BP_3 317.98 6.53 2640 861490133 XP_012921468.1 578 1.6e-56 PREDICTED: zinc finger protein 560 isoform X3 [Heterocephalus glaber] -- -- -- -- -- -- -- -- -- Q5MCW4 534 8.5e-53 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF02176//PF00096//PF13465//PF13912 TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.58170 BP_3 53.00 1.52 1973 546679640 ERL90071.1 745 5.2e-76 hypothetical protein D910_07426 [Dendroctonus ponderosae] 91091009 XM_969922.1 150 3.66458e-70 PREDICTED: Tribolium castaneum homeobox protein HMX3 (LOC663892), mRNA K09995 NKX3-2, BAPX1 homeobox protein Nkx-3.2 http://www.genome.jp/dbget-bin/www_bget?ko:K09995 P70061 323 1.9e-28 Homeobox protein Nkx-3.2 OS=Xenopus laevis GN=nkx3-2 PE=2 SV=1 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.58180 BP_3 7.76 8.25 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58184 BP_3 2.00 0.40 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58189 BP_3 120.81 0.95 6443 546679319 ERL89806.1 268 3.5e-20 hypothetical protein D910_07167 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.58194 BP_3 46.08 0.49 4792 642929553 XP_008195882.1 1723 5.0e-189 PREDICTED: DNA excision repair protein ERCC-6-like [Tribolium castaneum] 645002912 XM_008209837.1 85 1.22202e-33 PREDICTED: Nasonia vitripennis DNA excision repair protein ERCC-6-like (LOC100118952), transcript variant X3, mRNA K10841 ERCC6, CSB, RAD26 DNA excision repair protein ERCC-6 http://www.genome.jp/dbget-bin/www_bget?ko:K10841 Q03468 1203 4.1e-130 DNA excision repair protein ERCC-6 OS=Homo sapiens GN=ERCC6 PE=1 SV=1 PF00176//PF04851 SNF2 family N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0016787//GO:0003677 ATP binding//hydrolase activity//DNA binding -- -- KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) Cluster-8309.58202 BP_3 4.00 0.33 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58203 BP_3 60.70 0.66 4700 642920691 XP_008192524.1 507 5.0e-48 PREDICTED: DNA-binding protein D-ETS-4 isoform X3 [Tribolium castaneum]>gi|642920693|ref|XP_008192525.1| PREDICTED: DNA-binding protein D-ETS-4 isoform X3 [Tribolium castaneum]>gi|642920695|ref|XP_008192526.1| PREDICTED: DNA-binding protein D-ETS-4 isoform X3 [Tribolium castaneum] 195352940 XM_002042933.1 130 1.15673e-58 Drosophila sechellia GM16357 (Dsec\GM16357), mRNA K09442 SPDEF SAM pointed domain-containing ETS transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09442 P29775 454 2.8e-43 DNA-binding protein D-ETS-4 OS=Drosophila melanogaster GN=Ets98B PE=2 SV=3 PF00178 Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG3804 Transcription factor NERF and related proteins, contain ETS domain Cluster-8309.58205 BP_3 7.00 0.98 635 799368377 AKA64754.1 444 1.3e-41 C-type lectin 4 [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- P82596 167 7.3e-11 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58206 BP_3 22.00 4.92 507 1350937 P48855.1 600 8.8e-60 RecName: Full=40S ribosomal protein S14 [Procambarus clarkii]>gi|434787|dbj|BAA03461.1| ribosomal protein [Procambarus clarkii] 194763634 XM_001963902.1 186 8.7183e-91 Drosophila ananassae GF21290 (Dana\GF21290), mRNA K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 P48855 600 3.6e-61 40S ribosomal protein S14 OS=Procambarus clarkii GN=RPS14 PE=2 SV=1 PF00411//PF03423 Ribosomal protein S11//Carbohydrate binding domain (family 25) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:2001070 structural constituent of ribosome//starch binding GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-8309.5821 BP_3 7.00 0.46 1021 91085781 XP_974423.1 738 1.8e-75 PREDICTED: fas apoptotic inhibitory molecule 1 [Tribolium castaneum]>gi|270009996|gb|EFA06444.1| hypothetical protein TcasGA2_TC009326 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5H8 467 1.9e-45 Fas apoptotic inhibitory molecule 1 OS=Rattus norvegicus GN=Faim PE=2 SV=1 PF06905 Fas apoptotic inhibitory molecule (FAIM1) GO:0043066 negative regulation of apoptotic process -- -- -- -- KOG4352 Fas-mediated apoptosis inhibitor FAIM Cluster-8309.58210 BP_3 573.00 10.88 2829 189237783 XP_976374.2 1310 2.3e-141 PREDICTED: 2',5'-phosphodiesterase 12-like [Tribolium castaneum] -- -- -- -- -- K19612 PDE12 2',5'-phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19612 Q08DF7 673 6.9e-69 2',5'-phosphodiesterase 12 OS=Bos taurus GN=PDE12 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.58212 BP_3 9.00 1.35 612 754342353 XP_004365663.2 492 3.5e-47 ribosomal protein L41 [Capsaspora owczarzaki ATCC 30864]>gi|765548671|gb|KJE89292.1| ribosomal protein L41 [Capsaspora owczarzaki ATCC 30864] 697069074 XM_009651426.1 546 0 Verticillium dahliae VdLs.17 60S ribosomal protein L44 mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q4PNY0 526 1.7e-52 60S ribosomal protein L44 OS=Candida glycerinogenes GN=RPL44 PE=3 SV=3 PF00935 Ribosomal protein L44 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3464 60S ribosomal protein L44 Cluster-8309.58217 BP_3 49.43 0.74 3513 189239225 XP_973738.2 1287 1.3e-138 PREDICTED: orexin receptor type 2-like isoform X1 [Tribolium castaneum] 768433263 XM_011559691.1 93 3.19054e-38 PREDICTED: Plutella xylostella orexin receptor type 1-like (LOC105388735), mRNA K04239 HCRTR2 hypocretin (orexin) receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04239 O43614 608 3.0e-61 Orexin receptor type 2 OS=Homo sapiens GN=HCRTR2 PE=1 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.58219 BP_3 31.42 2.63 867 270008897 EFA05345.1 776 5.9e-80 hypothetical protein TcasGA2_TC015509 [Tribolium castaneum] 170028352 XM_001842008.1 81 3.58377e-32 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q8N6S4 549 5.1e-55 Ankyrin repeat domain-containing protein 13C OS=Homo sapiens GN=ANKRD13C PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0522 Ankyrin repeat protein Cluster-8309.58221 BP_3 1.00 0.37 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58222 BP_3 34.00 2.06 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58227 BP_3 18.28 0.48 2124 642917564 XP_008191258.1 1843 2.7e-203 PREDICTED: NF-X1-type zinc finger protein NFXL1 [Tribolium castaneum] -- -- -- -- -- K15683 NFXL1, OZFP NF-X1-type zinc finger protein NFXL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15683 Q6ZNB6 1326 9.9e-145 NF-X1-type zinc finger protein NFXL1 OS=Homo sapiens GN=NFXL1 PE=1 SV=2 PF08771//PF01422 Rapamycin binding domain//NF-X1 type zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003700//GO:0008144 zinc ion binding//transcription factor activity, sequence-specific DNA binding//drug binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.58228 BP_3 105.11 1.39 3938 270009970 EFA06418.1 1149 1.5e-122 hypothetical protein TcasGA2_TC009297 [Tribolium castaneum] 642927421 XM_962345.3 269 5.20099e-136 PREDICTED: Tribolium castaneum uncharacterized LOC655783 (LOC655783), mRNA -- -- -- -- -- -- -- -- PF06736 Protein of unknown function (DUF1211) GO:0006813 potassium ion transport GO:0005267 potassium channel activity -- -- -- -- Cluster-8309.58230 BP_3 12.00 3.53 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58231 BP_3 151.74 3.25 2541 91078782 XP_969464.1 1789 5.9e-197 PREDICTED: differentially expressed in FDCP 8 homolog [Tribolium castaneum]>gi|270004105|gb|EFA00553.1| hypothetical protein TcasGA2_TC003420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTT9 913 9.2e-97 Differentially expressed in FDCP 8 homolog OS=Drosophila melanogaster GN=CG11534 PE=1 SV=1 PF00130//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0008270//GO:0046872//GO:0047134 zinc ion binding//metal ion binding//protein-disulfide reductase activity GO:0005622 intracellular KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.58232 BP_3 277.00 6.77 2265 642927898 XP_973997.3 2097 1.0e-232 PREDICTED: gamma-tubulin complex component 4 [Tribolium castaneum]>gi|270009848|gb|EFA06296.1| hypothetical protein TcasGA2_TC009163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4F8 777 4.8e-81 Gamma-tubulin complex component 4 OS=Mus musculus GN=Tubgcp4 PE=2 SV=2 PF04130 Spc97 / Spc98 family GO:0090063//GO:0000226 positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0015630//GO:0044430//GO:0000922//GO:0005815 microtubule cytoskeleton//cytoskeletal part//spindle pole//microtubule organizing center KOG2065 Gamma-tubulin ring complex protein Cluster-8309.58237 BP_3 18.06 0.53 1921 642933995 XP_008197596.1 803 9.6e-83 PREDICTED: uncharacterized protein LOC100142086 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.58238 BP_3 13.94 0.37 2128 642933995 XP_008197596.1 618 3.0e-61 PREDICTED: uncharacterized protein LOC100142086 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12822 Protein of unknown function (DUF3816) GO:0006810 transport GO:0005215 transporter activity -- -- -- -- Cluster-8309.58239 BP_3 2.83 3.66 317 91078944 XP_974036.1 281 5.3e-23 PREDICTED: hamartin [Tribolium castaneum]>gi|270003690|gb|EFA00138.1| hypothetical protein TcasGA2_TC002959 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58242 BP_3 38.24 0.68 3015 270001558 EEZ98005.1 1616 8.1e-177 hypothetical protein TcasGA2_TC000404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1G0 226 5.0e-17 Zinc finger protein 687 OS=Homo sapiens GN=ZNF687 PE=1 SV=1 PF13912//PF09520//PF16622//PF13465//PF00096 C2H2-type zinc finger//Type II restriction endonuclease, TdeIII//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036//GO:0046872 DNA binding//Type II site-specific deoxyribonuclease activity//metal ion binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.58248 BP_3 34.32 0.39 4482 861616090 KMQ86259.1 2271 1.3e-252 retrovirus-related gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P04146 954 2.9e-101 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF00665//PF00098//PF13683 Integrase core domain//Zinc knuckle//Integrase core domain GO:0015074 DNA integration GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.5825 BP_3 12.92 1.10 856 642928921 XP_008195617.1 718 3.1e-73 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 235 1.3e-18 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF07819 PGAP1-like protein GO:0006886//GO:0006505 intracellular protein transport//GPI anchor metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.58252 BP_3 8.00 0.79 781 836700863 XP_012791490.1 150 2.0e-07 PREDICTED: PR domain zinc finger protein 15 [Sorex araneus] -- -- -- -- -- -- -- -- -- P57071 142 7.1e-08 PR domain zinc finger protein 15 OS=Homo sapiens GN=PRDM15 PE=2 SV=4 PF00412//PF13912//PF07975//PF05180//PF00096//PF13465 LIM domain//C2H2-type zinc finger//TFIIH C1-like domain//DNL zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.58256 BP_3 58.37 0.67 4483 642936143 XP_975059.2 1125 1.0e-119 PREDICTED: muscle segmentation homeobox [Tribolium castaneum] 198449863 XM_001357713.2 102 4.05186e-43 Drosophila pseudoobscura pseudoobscura GA15116 (Dpse\GA15116), partial mRNA K09341 MSX homeobox protein MSX http://www.genome.jp/dbget-bin/www_bget?ko:K09341 Q03372 541 2.2e-53 Muscle segmentation homeobox OS=Drosophila melanogaster GN=Dr PE=2 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0492 Transcription factor MSH, contains HOX domain Cluster-8309.58258 BP_3 19.37 0.39 2685 642935255 XP_008197934.1 829 1.3e-85 PREDICTED: coiled-coil domain-containing protein 142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58261 BP_3 3.00 0.34 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58263 BP_3 2.00 0.70 428 642939889 XP_008200206.1 222 5.0e-16 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05353 Delta Atracotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.58269 BP_3 142.85 4.44 1842 642938000 XP_008199165.1 419 3.1e-38 PREDICTED: uncharacterized protein LOC103314560 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O97148 178 1.1e-11 G-protein coupled receptor Mth OS=Drosophila melanogaster GN=mth PE=1 SV=1 PF06652//PF00002 Methuselah N-terminus//7 transmembrane receptor (Secretin family) GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.58271 BP_3 1.00 1.10 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58274 BP_3 9.11 1.11 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58276 BP_3 48.00 0.90 2870 751241471 XP_011174832.1 401 5.9e-36 PREDICTED: uncharacterized protein LOC105207089 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11654 Protein of unknown function (DUF2665) GO:0009306 protein secretion -- -- -- -- -- -- Cluster-8309.58277 BP_3 3.00 1.35 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58278 BP_3 1.00 0.39 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58283 BP_3 2.17 0.49 505 270008315 EFA04763.1 641 1.5e-64 hypothetical protein TcasGA2_TC030633, partial [Tribolium castaneum] 462325712 APGK01041724.1 83 1.57029e-33 Dendroctonus ponderosae Seq01041734, whole genome shotgun sequence K13861 SLC4A10, NCBE solute carrier family 4 (sodium bicarbonate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13861 Q6U841 503 6.4e-50 Sodium-driven chloride bicarbonate exchanger OS=Homo sapiens GN=SLC4A10 PE=2 SV=1 PF00955 HCO3- transporter family GO:0006820 anion transport -- -- GO:0016021 integral component of membrane KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.58288 BP_3 204.06 1.92 5420 642930933 XP_008196147.1 1374 1.7e-148 PREDICTED: RILP-like protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76878 969 6.3e-103 RILP-like protein homolog OS=Drosophila melanogaster GN=CG11448 PE=2 SV=1 PF04617//PF04111//PF07851//PF02465//PF05529//PF01401//PF09330//PF04728//PF01166//PF10473//PF15898//PF17060//PF00038//PF00769 Hox9 activation region//Autophagy protein Apg6//TMPIT-like protein//Flagellar hook-associated protein 2 N-terminus//B-cell receptor-associated protein 31-like//Angiotensin-converting enzyme//D-lactate dehydrogenase, membrane binding//Lipoprotein leucine-zipper//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//cGMP-dependent protein kinase interacting domain//Monopolar spindle protein 2//Intermediate filament protein//Ezrin/radixin/moesin family GO:0006351//GO:0030474//GO:0071988//GO:0006508//GO:0055085//GO:0006886//GO:0006914//GO:0006355 transcription, DNA-templated//spindle pole body duplication//protein localization to spindle pole body//proteolysis//transmembrane transport//intracellular protein transport//autophagy//regulation of transcription, DNA-templated GO:0008092//GO:0008237//GO:0050660//GO:0042803//GO:0008134//GO:0045502//GO:0008241//GO:0005198//GO:0019901//GO:0003700 cytoskeletal protein binding//metallopeptidase activity//flavin adenine dinucleotide binding//protein homodimerization activity//transcription factor binding//dynein binding//peptidyl-dipeptidase activity//structural molecule activity//protein kinase binding//transcription factor activity, sequence-specific DNA binding GO:0030286//GO:0019867//GO:0005634//GO:0005667//GO:0005783//GO:0009424//GO:0016020//GO:0016021//GO:0019898//GO:0005882//GO:0005737 dynein complex//outer membrane//nucleus//transcription factor complex//endoplasmic reticulum//bacterial-type flagellum hook//membrane//integral component of membrane//extrinsic component of membrane//intermediate filament//cytoplasm KOG2998 Uncharacterized conserved protein Cluster-8309.58291 BP_3 2.54 0.40 597 642919164 XP_008191764.1 290 9.1e-24 PREDICTED: forkhead box protein N3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58297 BP_3 2.01 0.59 457 270013778 EFA10226.1 288 1.2e-23 hypothetical protein TcasGA2_TC012422 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00170 bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.58298 BP_3 51.51 0.86 3175 15450324 AAK96031.1 912 3.6e-95 homeodomain transcription factor Prothoraxless [Tribolium castaneum]>gi|270002803|gb|EEZ99250.1| antennapedia [Tribolium castaneum] 86515363 NM_001039416.1 265 7.00128e-134 Tribolium castaneum prothoraxless (Ptl), mRNA >gnl|BL_ORD_ID|908858 Tribolium castaneum prothoraxless mRNA, complete cds K09307 HOX_7 homeobox protein HoxA/B7 http://www.genome.jp/dbget-bin/www_bget?ko:K09307 P02833 379 9.6e-35 Homeotic protein antennapedia OS=Drosophila melanogaster GN=Antp PE=1 SV=1 PF00046//PF03153 Homeobox domain//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.58299 BP_3 4305.00 110.89 2163 332374866 AEE62574.1 1742 1.4e-191 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q91YN5 1254 2.3e-136 UDP-N-acetylhexosamine pyrophosphorylase OS=Mus musculus GN=Uap1 PE=1 SV=1 PF01513//PF01704 ATP-NAD kinase//UTP--glucose-1-phosphate uridylyltransferase GO:0046497//GO:0006769//GO:0006741//GO:0008152 nicotinate nucleotide metabolic process//nicotinamide metabolic process//NADP biosynthetic process//metabolic process GO:0070569//GO:0003951 uridylyltransferase activity//NAD+ kinase activity -- -- KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.58300 BP_3 2.00 0.54 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58301 BP_3 230.66 4.31 2872 642936911 XP_008194442.1 3085 0.0e+00 PREDICTED: PHD finger protein 14 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4H9 1117 2.3e-120 PHD finger protein 14 OS=Mus musculus GN=Phf14 PE=1 SV=1 PF00130//PF01017//PF06156//PF00628//PF02059 Phorbol esters/diacylglycerol binding domain (C1 domain)//STAT protein, all-alpha domain//Protein of unknown function (DUF972)//PHD-finger//Interleukin-3 GO:0035556//GO:0006355//GO:0006260//GO:0006955//GO:0008283//GO:0040007//GO:0007165 intracellular signal transduction//regulation of transcription, DNA-templated//DNA replication//immune response//cell proliferation//growth//signal transduction GO:0003700//GO:0004871//GO:0005515//GO:0005135//GO:0008083 transcription factor activity, sequence-specific DNA binding//signal transducer activity//protein binding//interleukin-3 receptor binding//growth factor activity GO:0005576//GO:0005894//GO:0005667 extracellular region//interleukin-3 receptor complex//transcription factor complex KOG0957 PHD finger protein Cluster-8309.58305 BP_3 99.84 1.34 3891 91082901 XP_972219.1 678 6.1e-68 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Tribolium castaneum]>gi|270007610|gb|EFA04058.1| hypothetical protein TcasGA2_TC014291 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2PE14 512 4.4e-50 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2673 Uncharacterized conserved protein, contains PSP domain Cluster-8309.58307 BP_3 376.45 8.04 2548 270009116 EFA05564.1 1984 1.4e-219 hypothetical protein TcasGA2_TC015753 [Tribolium castaneum] 642926575 XM_008196705.1 163 2.8197e-77 PREDICTED: Tribolium castaneum putative fatty acyl-CoA reductase CG5065 (LOC656109), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1034 8.6e-111 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01370//PF01118//PF01073//PF03015 NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0051287//GO:0016616//GO:0003854//GO:0050662//GO:0003824//GO:0016620//GO:0080019 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.58308 BP_3 13.00 0.46 1657 642932711 XP_008196956.1 648 7.8e-65 PREDICTED: uncharacterized protein LOC103314018 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58309 BP_3 4.00 0.94 496 642932711 XP_008196956.1 248 5.6e-19 PREDICTED: uncharacterized protein LOC103314018 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58310 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58312 BP_3 42.50 1.36 1800 478257112 ENN77275.1 1084 2.4e-115 hypothetical protein YQE_06102, partial [Dendroctonus ponderosae]>gi|546683352|gb|ERL93174.1| hypothetical protein D910_10471 [Dendroctonus ponderosae] -- -- -- -- -- K11248 SH3GLB endophilin-B http://www.genome.jp/dbget-bin/www_bget?ko:K11248 Q5ZIR1 753 2.3e-78 Endophilin-B1 OS=Gallus gallus GN=SH3GLB1 PE=2 SV=1 PF03114 BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG3725 SH3 domain protein SH3GLB Cluster-8309.58314 BP_3 219.06 6.63 1885 91090914 XP_974006.1 2116 5.3e-235 PREDICTED: NCK-interacting protein with SH3 domain [Tribolium castaneum]>gi|270013220|gb|EFA09668.1| hypothetical protein TcasGA2_TC011794 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESJ4 782 1.1e-81 NCK-interacting protein with SH3 domain OS=Mus musculus GN=Nckipsd PE=2 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover Cluster-8309.58316 BP_3 1097.00 21.90 2706 642920697 XP_008192527.1 405 1.9e-36 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58320 BP_3 33.99 0.59 3089 546678378 ERL89011.1 589 1.0e-57 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 497 1.9e-48 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 PF04911 ATP synthase j chain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) KOG3936 Nitroreductases Cluster-8309.58323 BP_3 69.76 3.59 1229 91076372 XP_967795.1 1324 2.4e-143 PREDICTED: palmitoyltransferase ZDHHC6 [Tribolium castaneum] 871251020 XM_005104281.2 41 8.83977e-10 PREDICTED: Aplysia californica palmitoyltransferase ZDHHC6-like (LOC101847980), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9CPV7 758 4.2e-79 Palmitoyltransferase ZDHHC6 OS=Mus musculus GN=Zdhhc6 PE=2 SV=1 PF01363//PF01529 FYVE zinc finger//DHHC palmitoyltransferase -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1314 DHHC-type Zn-finger protein Cluster-8309.58325 BP_3 376.62 6.75 2982 91077428 XP_975436.1 1252 1.3e-134 PREDICTED: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A [Tribolium castaneum]>gi|270001628|gb|EEZ98075.1| hypothetical protein TcasGA2_TC000482 [Tribolium castaneum] -- -- -- -- -- K07442 TRM61, GCD14 tRNA (adenine57-N1/adenine58-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07442 A6H791 696 1.6e-71 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Bos taurus GN=TRMT61A PE=2 SV=1 PF08704//PF01135//PF06816//PF03009 tRNA methyltransferase complex GCD14 subunit//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//NOTCH protein//Glycerophosphoryl diester phosphodiesterase family GO:0030488//GO:0006629//GO:0006464//GO:0046500//GO:0008033//GO:0030154//GO:0006479//GO:0009451 tRNA methylation//lipid metabolic process//cellular protein modification process//S-adenosylmethionine metabolic process//tRNA processing//cell differentiation//protein methylation//RNA modification GO:0016429//GO:0008081//GO:0004719 tRNA (adenine-N1-)-methyltransferase activity//phosphoric diester hydrolase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0016021//GO:0031515 integral component of membrane//tRNA (m1A) methyltransferase complex KOG2915 tRNA(1-methyladenosine) methyltransferase, subunit GCD14 Cluster-8309.58327 BP_3 1.00 1.06 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58328 BP_3 17.68 0.65 1605 642927459 XP_968905.2 1151 3.6e-123 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q14914 756 9.3e-79 Prostaglandin reductase 1 OS=Homo sapiens GN=PTGR1 PE=1 SV=2 PF00107//PF01370//PF01118//PF00208 Zinc-binding dehydrogenase//NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016620//GO:0016491//GO:0051287//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity//NAD binding//catalytic activity//coenzyme binding -- -- KOG1196 Predicted NAD-dependent oxidoreductase Cluster-8309.58330 BP_3 12.50 0.63 1241 -- -- -- -- -- 262401228 FJ774796.1 572 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.58332 BP_3 512.45 32.07 1062 780671061 XP_011695254.1 187 1.4e-11 PREDICTED: uncharacterized protein LOC105454377 [Wasmannia auropunctata]>gi|780671066|ref|XP_011695256.1| PREDICTED: uncharacterized protein LOC105454377 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00236//PF00341 Glycoprotein hormone//PDGF/VEGF domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0005179//GO:0008083 hormone activity//growth factor activity GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.58335 BP_3 17.87 1.48 874 332376071 AEE63176.1 496 1.7e-47 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q60534 227 1.1e-17 Androgen-dependent TFPI-regulating protein OS=Mesocricetus auratus GN=ADTRP PE=2 SV=1 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.58337 BP_3 3.00 1.28 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58339 BP_3 4.00 0.48 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58342 BP_3 33.94 0.54 3300 642934150 XP_008199297.1 2116 9.3e-235 PREDICTED: lethal(3)malignant brain tumor-like protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96JM7 1097 5.5e-118 Lethal(3)malignant brain tumor-like protein 3 OS=Homo sapiens GN=L3MBTL3 PE=1 SV=2 PF02820//PF11109 mbt repeat//Orexigenic neuropeptide Qrfp/P518 GO:0006355 regulation of transcription, DNA-templated GO:0031854 orexigenic neuropeptide QRFP receptor binding GO:0005634 nucleus -- -- Cluster-8309.58343 BP_3 4.00 1.19 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58344 BP_3 147.40 6.49 1387 332374692 AEE62487.1 751 7.4e-77 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8QZW3 348 1.6e-31 Protein FAM151A OS=Mus musculus GN=Fam151a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58345 BP_3 134.73 15.16 720 642910891 XP_972272.3 724 5.2e-74 PREDICTED: SLIT-ROBO Rho GTPase-activating protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K07526 SRGAP SLIT-ROBO Rho GTPase activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K07526 B0S6J3 269 1.2e-22 SLIT-ROBO Rho GTPase-activating protein 2 OS=Danio rerio GN=srgap2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58346 BP_3 13.12 0.41 1848 -- -- -- -- -- 338224420 HM217854.1 217 1.94973e-107 Scylla paramamosain retinitis pigmentosa GTPase regulator-like protein-like protein-like mRNA, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58348 BP_3 3.00 0.38 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58355 BP_3 3847.94 39.99 4930 478259242 ENN79144.1 1222 6.4e-131 hypothetical protein YQE_04330, partial [Dendroctonus ponderosae]>gi|546678424|gb|ERL89047.1| hypothetical protein D910_06425 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGY6 914 1.4e-96 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- -- -- Cluster-8309.58356 BP_3 3.00 0.36 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5836 BP_3 1.00 0.39 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58364 BP_3 72.95 1.04 3666 642934335 XP_969733.2 2984 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X5 [Tribolium castaneum] 817086197 XM_012410395.1 92 1.19802e-37 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 448 1.1e-42 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF02601//PF01580//PF13639//PF05149//PF01637//PF09815//PF05524//PF01436//PF00643//PF14634//PF00097//PF05929 Exonuclease VII, large subunit//FtsK/SpoIIIE family//Ring finger domain//Paraflagellar rod protein//Archaeal ATPase//XK-related protein//PEP-utilising enzyme, N-terminal//NHL repeat//B-box zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Phage capsid scaffolding protein (GPO) serine peptidase GO:0006308//GO:0019069//GO:0009401 DNA catabolic process//viral capsid assembly//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0008855//GO:0003677//GO:0005516//GO:0005524//GO:0046872//GO:0008270//GO:0000166 protein binding//exodeoxyribonuclease VII activity//DNA binding//calmodulin binding//ATP binding//metal ion binding//zinc ion binding//nucleotide binding GO:0031514//GO:0016021//GO:0005622//GO:0009318 motile cilium//integral component of membrane//intracellular//exodeoxyribonuclease VII complex -- -- Cluster-8309.58366 BP_3 404.32 35.87 835 91093337 XP_976060.1 141 2.4e-06 PREDICTED: uncharacterized protein LOC655475 [Tribolium castaneum]>gi|270015235|gb|EFA11683.1| hypothetical protein TcasGA2_TC008547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58367 BP_3 1.00 0.92 337 861605932 KMQ84424.1 181 2.2e-11 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58373 BP_3 12.22 0.45 1597 270011132 EFA07580.1 1336 1.3e-144 hypothetical protein TcasGA2_TC016363 [Tribolium castaneum]>gi|485836803|tpg|DAA64486.1| TPA_inf: G protein-coupled receptor Tc 45 [Tribolium castaneum] -- -- -- -- -- K04226 AVPR1A arginine vasopressin receptor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04226 Q7YW31 649 2.4e-66 Cephalotocin receptor 1 OS=Octopus vulgaris GN=CTR1 PE=2 SV=1 PF09446//PF00001 VMA21-like domain//7 transmembrane receptor (rhodopsin family) GO:0070072//GO:0007186 vacuolar proton-transporting V-type ATPase complex assembly//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.58375 BP_3 38.00 2.70 969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.58376 BP_3 7.72 0.37 1286 642936428 XP_008198430.1 820 6.9e-85 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462294748 APGK01052997.1 59 9.13164e-20 Dendroctonus ponderosae Seq01053007, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 246 1.0e-19 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58378 BP_3 92.71 0.65 7219 642935386 XP_008197990.1 2226 3.6e-247 PREDICTED: histone acetyltransferase KAT7 [Tribolium castaneum] -- -- -- -- -- K11307 MYST2, HBO1, KAT7 histone acetyltransferase MYST2 http://www.genome.jp/dbget-bin/www_bget?ko:K11307 Q810T5 1269 1.4e-137 Histone acetyltransferase KAT7 OS=Rattus norvegicus GN=Kat7 PE=2 SV=1 PF13508//PF01853//PF01530 Acetyltransferase (GNAT) domain//MOZ/SAS family//Zinc finger, C2HC type GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0016747//GO:0003700//GO:0008270//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//transcription factor activity, sequence-specific DNA binding//zinc ion binding//N-acetyltransferase activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.5838 BP_3 42.17 1.31 1848 478251528 ENN71990.1 1497 3.1e-163 hypothetical protein YQE_11281, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H8E8 659 1.9e-67 Cysteine-rich protein 2-binding protein OS=Homo sapiens GN=CSRP2BP PE=1 SV=3 PF00583//PF13508//PF08445//PF13673//PF02576//PF00130//PF00628//PF16866 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Putative ribosome maturation factor RimP//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//PHD-finger GO:0042274//GO:0042967//GO:0035556 ribosomal small subunit biogenesis//acyl-carrier-protein biosynthetic process//intracellular signal transduction GO:0016747//GO:0005515//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//N-acetyltransferase activity -- -- -- -- Cluster-8309.58383 BP_3 26.76 1.83 997 646711122 KDR16421.1 317 1.1e-26 Protein bric-a-brac 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W0K4 225 2.2e-17 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.58384 BP_3 28.59 3.26 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58388 BP_3 130.24 4.03 1850 478257462 ENN77618.1 921 1.9e-96 hypothetical protein YQE_05913, partial [Dendroctonus ponderosae]>gi|546679856|gb|ERL90244.1| hypothetical protein D910_07597 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBW5 222 8.9e-17 Zinc finger HIT domain-containing protein 2 OS=Bos taurus GN=ZNHIT2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4317 Predicted Zn-finger protein Cluster-8309.58389 BP_3 202.76 6.36 1829 478257462 ENN77618.1 921 1.9e-96 hypothetical protein YQE_05913, partial [Dendroctonus ponderosae]>gi|546679856|gb|ERL90244.1| hypothetical protein D910_07597 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBW5 222 8.8e-17 Zinc finger HIT domain-containing protein 2 OS=Bos taurus GN=ZNHIT2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4317 Predicted Zn-finger protein Cluster-8309.5839 BP_3 25.06 0.73 1949 478251528 ENN71990.1 1682 1.2e-184 hypothetical protein YQE_11281, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H8E8 621 5.1e-63 Cysteine-rich protein 2-binding protein OS=Homo sapiens GN=CSRP2BP PE=1 SV=3 PF02576//PF00130//PF00583//PF13508//PF13673//PF00628//PF16866 Putative ribosome maturation factor RimP//Phorbol esters/diacylglycerol binding domain (C1 domain)//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//PHD-finger//PHD-finger GO:0042274//GO:0035556//GO:0042967 ribosomal small subunit biogenesis//intracellular signal transduction//acyl-carrier-protein biosynthetic process GO:0008080//GO:0005515 N-acetyltransferase activity//protein binding -- -- -- -- Cluster-8309.58398 BP_3 86.45 1.50 3078 642928968 XP_008195638.1 212 5.2e-14 PREDICTED: FK506-binding protein 5-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05932 Tir chaperone protein (CesT) family GO:0050708 regulation of protein secretion -- -- GO:0005737 cytoplasm -- -- Cluster-8309.584 BP_3 229.00 35.00 607 768408833 XP_011549482.1 145 6.1e-07 PREDICTED: endocuticle structural glycoprotein ABD-4-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q8MUC5 127 3.0e-06 Pupal cuticle protein 36 OS=Manduca sexta GN=PCP36 PE=1 SV=1 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.58400 BP_3 115.00 3.53 1860 642927549 XP_971699.2 801 1.6e-82 PREDICTED: single-strand selective monofunctional uracil DNA glycosylase [Tribolium castaneum] -- -- -- -- -- K10800 SMUG1 single-strand selective monofunctional uracil DNA glycosylase http://www.genome.jp/dbget-bin/www_bget?ko:K10800 Q9YGN6 564 2.0e-56 Single-strand selective monofunctional uracil DNA glycosylase OS=Xenopus laevis GN=smug1 PE=1 SV=1 PF00383//PF08210 Cytidine and deoxycytidylate deaminase zinc-binding region//APOBEC-like N-terminal domain GO:0006807 nitrogen compound metabolic process GO:0016814//GO:0008270 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines//zinc ion binding -- -- KOG1018 Cytosine deaminase FCY1 and related enzymes Cluster-8309.58403 BP_3 296.90 10.23 1690 642918258 XP_008191434.1 1452 4.7e-158 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918260|ref|XP_008191435.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918262|ref|XP_008191436.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 Q1HG43 346 3.4e-31 Dual oxidase maturation factor 1 OS=Homo sapiens GN=DUOXA1 PE=1 SV=1 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG3921 Uncharacterized conserved protein Cluster-8309.58404 BP_3 5.38 0.61 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58405 BP_3 54.83 0.80 3615 270001283 EEZ97730.1 1441 1.9e-156 stumps [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 160 2.7e-09 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136//PF01496 Sec34-like family//V-type ATPase 116kDa subunit family GO:0015991//GO:0006886//GO:0015992 ATP hydrolysis coupled proton transport//intracellular protein transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179//GO:0016020//GO:0005801 proton-transporting V-type ATPase, V0 domain//membrane//cis-Golgi network -- -- Cluster-8309.58406 BP_3 4.00 2.27 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58410 BP_3 210.41 2.04 5262 761263427 AJP36493.1 2253 1.9e-250 nicotinic acetylcholine receptor alpha 7 [Leptinotarsa decemlineata] 158262732 NM_001109950.1 450 0 Tribolium castaneum nicotinic acetylcholine receptor alpha 7 subunit (nAChRa7), mRNA >gnl|BL_ORD_ID|4646358 Tribolium castaneum nicotinic acetylcholine receptor subunit alpha7 mRNA, complete cds K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P48180 1064 5.9e-114 Acetylcholine receptor subunit alpha-type acr-16 OS=Caenorhabditis elegans GN=acr-16 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3646 Acetylcholine receptor Cluster-8309.58411 BP_3 1.00 0.33 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14554 VEGF heparin-binding domain -- -- GO:0008201 heparin binding -- -- -- -- Cluster-8309.58412 BP_3 44.29 0.57 4037 270006253 EFA02701.1 3335 0.0e+00 hypothetical protein TcasGA2_TC008423 [Tribolium castaneum] 3511174 AF064514.1 390 0 AF064514 Manduca sexta soluble guanylyl cyclase beta-3 mRNA, complete cds K01769 E4.6.1.2 guanylate cyclase, other http://www.genome.jp/dbget-bin/www_bget?ko:K01769 Q8INF0 2650 5.6e-298 Soluble guanylate cyclase 88E OS=Drosophila melanogaster GN=Gyc88E PE=1 SV=3 PF00211//PF07700//PF07701 Adenylate and Guanylate cyclase catalytic domain//Haem-NO-binding//Heme NO binding associated GO:0006182//GO:0046039//GO:0006144//GO:0035556//GO:0009190 cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0004383//GO:0020037//GO:0016849 guanylate cyclase activity//heme binding//phosphorus-oxygen lyase activity -- -- KOG4171 Adenylate/guanylate kinase Cluster-8309.58415 BP_3 16.85 0.31 2938 795012910 XP_011880473.1 1507 3.4e-164 PREDICTED: uncharacterized protein LOC105568978 [Vollenhovia emeryi]>gi|795012913|ref|XP_011880481.1| PREDICTED: uncharacterized protein LOC105568978 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699//PF01480 hAT family C-terminal dimerisation region//PWI domain GO:0006397 mRNA processing GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.58420 BP_3 1.02 0.36 428 478257602 ENN77754.1 241 3.1e-18 hypothetical protein YQE_05726, partial [Dendroctonus ponderosae]>gi|546677506|gb|ERL88332.1| hypothetical protein D910_05719, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58422 BP_3 137.00 1.90 3775 564248485 XP_006263331.1 699 2.2e-70 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 660 3.0e-67 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF16622//PF01428//PF13912//PF02892//PF13465//PF07776//PF06467//PF04858//PF01155//PF00130//PF02176//PF00096 zinc-finger C2H2-type//AN1-like Zinc finger//C2H2-type zinc finger//BED zinc finger//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//TH1 protein//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//TRAF-type zinc finger//Zinc finger, C2H2 type GO:0006464//GO:0035556//GO:0045892 cellular protein modification process//intracellular signal transduction//negative regulation of transcription, DNA-templated GO:0016151//GO:0003677//GO:0046872//GO:0008270 nickel cation binding//DNA binding//metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.58427 BP_3 68.00 3.35 1270 91087937 XP_971924.1 1053 6.5e-112 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 [Tribolium castaneum]>gi|270011936|gb|EFA08384.1| hypothetical protein TcasGA2_TC006028 [Tribolium castaneum] -- -- -- -- -- K10766 ALKBH4 alkylated DNA repair protein alkB homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10766 Q9D8F1 548 9.7e-55 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Mus musculus GN=Alkbh4 PE=2 SV=1 PF03171 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3959 2-Oxoglutarate- and iron-dependent dioxygenase-related proteins Cluster-8309.58429 BP_3 9.00 0.62 997 817060127 XP_012251601.1 744 3.5e-76 PREDICTED: kinesin-related protein 4 [Athalia rosae] -- -- -- -- -- K11498 CENPE centromeric protein E http://www.genome.jp/dbget-bin/www_bget?ko:K11498 Q54NP8 564 1.1e-56 Kinesin-related protein 4 OS=Dictyostelium discoideum GN=kif4 PE=2 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0003777//GO:0005524//GO:0008017 microtubule motor activity//ATP binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG0242 Kinesin-like protein Cluster-8309.58431 BP_3 30.22 1.03 1705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58437 BP_3 14.00 0.83 1105 294938638 XP_002782134.1 172 8.2e-10 microneme protein 12, putative [Perkinsus marinus ATCC 50983]>gi|239893612|gb|EER13929.1| microneme protein 12, putative [Perkinsus marinus ATCC 50983] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5844 BP_3 63.36 1.86 1936 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58440 BP_3 1.00 3.30 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58443 BP_3 46.99 3.05 1034 546683188 ERL93032.1 509 6.4e-49 hypothetical protein D910_10334 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF12844//PF01381 Transposase//Helix-turn-helix domain//Helix-turn-helix GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.58444 BP_3 91.00 6.29 989 861631908 KMQ90492.1 544 5.3e-53 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58449 BP_3 156.74 1.06 7402 795009393 XP_011861480.1 687 1.0e-68 PREDICTED: uncharacterized protein LOC105558418 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05829//PF04513//PF00580//PF07851//PF01637//PF01367 Adenovirus late L2 mu core protein (Protein X)//Baculovirus polyhedron envelope protein, PEP, C terminus//UvrD/REP helicase N-terminal domain//TMPIT-like protein//Archaeal ATPase//5'-3' exonuclease, C-terminal SAM fold -- -- GO:0005198//GO:0003824//GO:0005524//GO:0003677 structural molecule activity//catalytic activity//ATP binding//DNA binding GO:0019031//GO:0016021//GO:0019028//GO:0019013 viral envelope//integral component of membrane//viral capsid//viral nucleocapsid -- -- Cluster-8309.58452 BP_3 181.97 1.48 6219 91090584 XP_972498.1 2433 3.0e-271 PREDICTED: histone H2A deubiquitinase MYSM1 isoform X1 [Tribolium castaneum]>gi|270013339|gb|EFA09787.1| hypothetical protein TcasGA2_TC011929 [Tribolium castaneum] -- -- -- -- -- K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 P55216 782 3.5e-81 Putative cystathionine gamma-lyase 2 OS=Caenorhabditis elegans GN=cth-2 PE=3 SV=1 PF04433//PF01398//PF01053//PF02347//PF00155 SWIRM domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Cys/Met metabolism PLP-dependent enzyme//Glycine cleavage system P-protein//Aminotransferase class I and II GO:0009058//GO:0006544//GO:0006546//GO:0055114//GO:0006566//GO:0006563 biosynthetic process//glycine metabolic process//glycine catabolic process//oxidation-reduction process//threonine metabolic process//L-serine metabolic process GO:0005488//GO:0004375//GO:0005515//GO:0030170 binding//glycine dehydrogenase (decarboxylating) activity//protein binding//pyridoxal phosphate binding -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.58454 BP_3 346.35 7.36 2559 167234455 NP_001107843.1 1160 5.1e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.4e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58455 BP_3 40.68 0.77 2850 167234455 NP_001107843.1 1160 5.7e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.6e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58456 BP_3 35.19 0.82 2357 478262135 ENN81017.1 1410 4.9e-153 hypothetical protein YQE_02571, partial [Dendroctonus ponderosae]>gi|546685376|gb|ERL94894.1| hypothetical protein D910_12167 [Dendroctonus ponderosae] -- -- -- -- -- K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 703 1.9e-72 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF01053//PF00155 Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.58458 BP_3 10.00 0.57 1133 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58459 BP_3 3.00 0.42 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168 Triple QxxK/R motif-containing protein family -- -- -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.58460 BP_3 2.00 0.39 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58461 BP_3 63.64 4.26 1012 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58463 BP_3 1686.00 27.40 3258 642913541 XP_008201055.1 809 3.3e-83 PREDICTED: uncharacterized protein LOC660464 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.58470 BP_3 7.88 0.75 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58472 BP_3 17.00 0.79 1327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58473 BP_3 4.00 0.43 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02444 Hepatitis E virus ORF-2 (Putative capsid protein) -- -- -- -- GO:0030430 host cell cytoplasm -- -- Cluster-8309.58474 BP_3 8.00 1.15 627 768408833 XP_011549482.1 175 2.1e-10 PREDICTED: endocuticle structural glycoprotein ABD-4-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q7M4F4 148 1.2e-08 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.58477 BP_3 2.00 47.55 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58481 BP_3 50.90 0.48 5394 270007698 EFA04146.1 651 1.1e-64 hypothetical protein TcasGA2_TC014390 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R0K2 151 4.5e-08 E3 ubiquitin-protein ligase TRIM31 OS=Mus musculus GN=Trim31 PE=1 SV=1 PF11789//PF13639//PF14634//PF17123//PF00097//PF15957 Zinc-finger of the MIZ type in Nse subunit//Ring finger domain//zinc-RING finger domain//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger)//Commissureless GO:0007411 axon guidance GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.58483 BP_3 28.00 8.50 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58487 BP_3 151.36 2.27 3507 642927046 XP_008195117.1 1375 8.3e-149 PREDICTED: putative ATP-dependent RNA helicase DHX30 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13185 DHX30 ATP-dependent RNA helicase DHX30 http://www.genome.jp/dbget-bin/www_bget?ko:K13185 Q5ZI74 649 5.2e-66 Putative ATP-dependent RNA helicase DHX30 OS=Gallus gallus GN=DHX30 PE=2 SV=1 PF00270//PF03193//PF04408 DEAD/DEAH box helicase//Protein of unknown function, DUF258//Helicase associated domain (HA2) -- -- GO:0003924//GO:0003676//GO:0005524//GO:0005525//GO:0004386 GTPase activity//nucleic acid binding//ATP binding//GTP binding//helicase activity -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.58488 BP_3 697.95 9.64 3783 642921031 XP_008192662.1 1730 6.1e-190 PREDICTED: harmonin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ0 398 7.2e-37 Harmonin OS=Bos taurus GN=USH1C PE=2 SV=1 PF00595//PF13180//PF01402//PF02517 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Ribbon-helix-helix protein, copG family//CAAX protease self-immunity GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.58490 BP_3 20.00 1.38 990 -- -- -- -- -- 768311752 CP010980.1 984 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- PF04005 Hus1-like protein GO:0006281//GO:0000077 DNA repair//DNA damage checkpoint -- -- GO:0030896 checkpoint clamp complex -- -- Cluster-8309.58494 BP_3 67.88 1.37 2680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58495 BP_3 9.12 0.83 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58496 BP_3 162.22 1.65 5020 642922539 XP_008193217.1 440 3.1e-40 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SYC1 187 2.8e-12 Clavesin-2 OS=Homo sapiens GN=CLVS2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58497 BP_3 3941.78 109.17 2032 642922539 XP_008193217.1 1116 5.2e-119 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUQ0 426 2.2e-40 Clavesin-1 OS=Homo sapiens GN=CLVS1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58499 BP_3 700.64 15.61 2455 332375292 AEE62787.1 442 8.9e-41 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MUC5 306 2.2e-26 Pupal cuticle protein 36 OS=Manduca sexta GN=PCP36 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.585 BP_3 275.00 174.81 364 642924221 XP_008194204.1 341 6.8e-30 PREDICTED: endocuticle structural glycoprotein SgAbd-2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 184 4.5e-13 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.58502 BP_3 313.96 5.77 2915 189241581 XP_969604.2 2442 1.3e-272 PREDICTED: phosphoinositide 3-kinase adapter protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.6e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0016020//GO:0005801 membrane//cis-Golgi network -- -- Cluster-8309.58504 BP_3 37.47 0.45 4274 642919551 XP_008191919.1 1538 1.3e-167 PREDICTED: synaptotagmin-12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IV01 498 2.0e-48 Synaptotagmin-12 OS=Homo sapiens GN=SYT12 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.58506 BP_3 5.00 0.32 1036 478254324 ENN74578.1 150 2.7e-07 hypothetical protein YQE_08900, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702 Fibrinogen alpha/beta chain family GO:0007165//GO:0030168//GO:0051258 signal transduction//platelet activation//protein polymerization GO:0030674//GO:0005102 protein binding, bridging//receptor binding GO:0005577 fibrinogen complex -- -- Cluster-8309.58507 BP_3 21.08 0.88 1451 642922431 XP_008193164.1 1068 1.4e-113 PREDICTED: gustatory receptor Gr83 isoform X2 [Tribolium castaneum] -- -- -- -- -- K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 988 1.1e-105 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1440 CDP-diacylglycerol synthase Cluster-8309.58508 BP_3 8.92 0.34 1572 642922431 XP_008193164.1 1068 1.5e-113 PREDICTED: gustatory receptor Gr83 isoform X2 [Tribolium castaneum] -- -- -- -- -- K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 988 1.1e-105 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1440 CDP-diacylglycerol synthase Cluster-8309.58509 BP_3 6.77 0.57 860 91084083 XP_966773.1 418 1.9e-38 PREDICTED: uncharacterized protein LOC656652 [Tribolium castaneum]>gi|270008009|gb|EFA04457.1| hypothetical protein TcasGA2_TC014761 [Tribolium castaneum] 462298889 APGK01051512.1 60 1.67692e-20 Dendroctonus ponderosae Seq01051522, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58511 BP_3 6171.93 80.03 4009 642932423 XP_008197105.1 482 3.3e-45 PREDICTED: uncharacterized protein LOC103314057 [Tribolium castaneum]>gi|270011584|gb|EFA08032.1| hypothetical protein TcasGA2_TC005621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58512 BP_3 5642.07 72.92 4021 642932423 XP_008197105.1 482 3.4e-45 PREDICTED: uncharacterized protein LOC103314057 [Tribolium castaneum]>gi|270011584|gb|EFA08032.1| hypothetical protein TcasGA2_TC005621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58513 BP_3 5.00 1.25 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02444 Hepatitis E virus ORF-2 (Putative capsid protein) -- -- -- -- GO:0030430 host cell cytoplasm -- -- Cluster-8309.58514 BP_3 58.21 1.65 1988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58518 BP_3 46.32 0.51 4656 478257224 ENN77387.1 1354 3.0e-146 hypothetical protein YQE_06212, partial [Dendroctonus ponderosae] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM91 717 9.0e-74 Tubulin glycylase 3A OS=Drosophila melanogaster GN=TTLL3A PE=1 SV=1 PF00299//PF03133//PF07525 Squash family serine protease inhibitor//Tubulin-tyrosine ligase family//SOCS box GO:0006464//GO:0035556 cellular protein modification process//intracellular signal transduction GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.58519 BP_3 48.00 2.84 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5852 BP_3 8.00 0.84 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58520 BP_3 47.65 0.77 3289 91083281 XP_974400.1 660 6.3e-66 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|270007725|gb|EFA04173.1| hypothetical protein TcasGA2_TC014422 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58521 BP_3 26.41 1.09 1459 478257123 ENN77286.1 746 3.0e-76 hypothetical protein YQE_06112, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9JR78 134 1.1e-06 Tonsoku-like protein OS=Danio rerio GN=tonsl PE=2 SV=1 PF00023//PF13606//PF02976 Ankyrin repeat//Ankyrin repeat//DNA mismatch repair enzyme MutH -- -- GO:0005515//GO:0004519//GO:0003677 protein binding//endonuclease activity//DNA binding -- -- -- -- Cluster-8309.58524 BP_3 32.45 14.14 401 270016638 EFA13084.1 139 2.0e-06 hypothetical protein TcasGA2_TC011584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06467//PF02892 MYM-type Zinc finger with FCS sequence motif//BED zinc finger -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- -- -- Cluster-8309.58525 BP_3 116.30 8.43 957 270016638 EFA13084.1 140 3.6e-06 hypothetical protein TcasGA2_TC011584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF06467 BED zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- -- -- Cluster-8309.58527 BP_3 5367.63 122.95 2396 91087671 XP_976426.1 247 3.6e-18 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58528 BP_3 81.56 0.55 7406 270007892 EFA04340.1 5490 0.0e+00 hypothetical protein TcasGA2_TC014634 [Tribolium castaneum] 627401361 KF147149.1 760 0 Anthonomus grandis chitin synthase I (CHS1) mRNA, complete cds K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q4P9K9 230 4.2e-17 Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=CHS8 PE=3 SV=1 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG2571 Chitin synthase/hyaluronan synthase (glycosyltransferases) Cluster-8309.58531 BP_3 337.38 2.36 7170 642929979 XP_008196051.1 1519 3.4e-165 PREDICTED: centromere-associated protein E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02224 485 1.1e-46 Centromere-associated protein E OS=Homo sapiens GN=CENPE PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58532 BP_3 127.62 0.87 7390 270010587 EFA07035.1 1491 6.2e-162 hypothetical protein TcasGA2_TC010007 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02224 485 1.1e-46 Centromere-associated protein E OS=Homo sapiens GN=CENPE PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58545 BP_3 12.00 0.86 962 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58547 BP_3 124.52 2.31 2890 270003148 EEZ99595.1 382 9.5e-34 hypothetical protein TcasGA2_TC001582 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58550 BP_3 410.33 20.43 1260 150416593 ABF60889.2 192 4.5e-12 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58551 BP_3 40.38 0.44 4721 332376491 AEE63385.1 1362 3.6e-147 unknown [Dendroctonus ponderosae]>gi|546680485|gb|ERL90751.1| hypothetical protein D910_08098 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q16T79 1220 4.3e-132 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Aedes aegypti GN=AAEL010360 PE=3 SV=2 PF03082//PF01920//PF02951//PF00437//PF01583//PF07728//PF08702//PF00931//PF08912//PF06414//PF07989//PF09177//PF03193//PF00005 Male accessory gland secretory protein//Prefoldin subunit//Prokaryotic glutathione synthetase, N-terminal domain//Type II/IV secretion system protein//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//Fibrinogen alpha/beta chain family//NB-ARC domain//Rho Binding//Zeta toxin//Centrosomin N-terminal motif 1//Syntaxin 6, N-terminal//Protein of unknown function, DUF258//ABC transporter GO:0030168//GO:0007618//GO:0048193//GO:0000103//GO:0006144//GO:0006457//GO:0006750//GO:0006810//GO:0051258//GO:0007165 platelet activation//mating//Golgi vesicle transport//sulfate assimilation//purine nucleobase metabolic process//protein folding//glutathione biosynthetic process//transport//protein polymerization//signal transduction GO:0017048//GO:0005525//GO:0030674//GO:0004020//GO:0043531//GO:0004363//GO:0016301//GO:0016887//GO:0005102//GO:0051082//GO:0003924//GO:0005524 Rho GTPase binding//GTP binding//protein binding, bridging//adenylylsulfate kinase activity//ADP binding//glutathione synthase activity//kinase activity//ATPase activity//receptor binding//unfolded protein binding//GTPase activity//ATP binding GO:0016020//GO:0005576//GO:0016272//GO:0005577//GO:0005815 membrane//extracellular region//prefoldin complex//fibrinogen complex//microtubule organizing center KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.58555 BP_3 37.96 1.55 1475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00647//PF08066 Elongation factor 1 gamma, conserved domain//PMC2NT (NUC016) domain GO:0006414//GO:0006396//GO:0006448 translational elongation//RNA processing//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840//GO:0000176 ribosome//nuclear exosome (RNase complex) -- -- Cluster-8309.58558 BP_3 140.57 1.77 4111 189239721 XP_967180.2 687 5.8e-69 PREDICTED: GATA zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270010752|gb|EFA07200.1| hypothetical protein TcasGA2_TC010207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUU5 377 2.1e-34 GATA zinc finger domain-containing protein 1 OS=Homo sapiens GN=GATAD1 PE=1 SV=1 PF04921//PF00320 XAP5, circadian clock regulator//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.5856 BP_3 1.00 2.80 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58562 BP_3 39.98 3.97 777 91080431 XP_968599.1 301 6.3e-25 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05715 Piccolo Zn-finger -- -- GO:0046872 metal ion binding GO:0045202 synapse -- -- Cluster-8309.58563 BP_3 145.00 8.58 1106 189241864 XP_971367.2 845 7.5e-88 PREDICTED: uncharacterized protein LOC660010 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58564 BP_3 8.00 0.40 1258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06440 DNA polymerase III, theta subunit GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.58565 BP_3 79.82 0.89 4630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58568 BP_3 235.75 3.01 4064 642921033 XP_008192663.1 1730 6.6e-190 PREDICTED: harmonin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ0 398 7.7e-37 Harmonin OS=Bos taurus GN=USH1C PE=2 SV=1 PF01402//PF02517//PF13180//PF00595 Ribbon-helix-helix protein, copG family//CAAX protease self-immunity//PDZ domain//PDZ domain (Also known as DHR or GLGF) GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.5857 BP_3 1.00 0.31 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58573 BP_3 6.73 0.92 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58574 BP_3 1.52 1.61 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58575 BP_3 242.57 50.53 523 546684343 ERL94048.1 160 9.4e-09 hypothetical protein D910_11331 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58576 BP_3 267.92 1.84 7309 642914165 XP_008201572.1 151 1.5e-06 PREDICTED: uncharacterized protein LOC100142379 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58578 BP_3 61.00 1.73 1989 -- -- -- -- -- 768311755 CP010983.1 1905 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58589 BP_3 61.64 0.88 3652 815896315 XP_012246840.1 676 9.7e-68 PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896317|ref|XP_012246847.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896319|ref|XP_012246857.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- P19217 395 1.5e-36 Estrogen sulfotransferase OS=Bos taurus GN=SULT1E1 PE=1 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.58590 BP_3 45.47 0.66 3617 805810681 XP_012147200.1 495 9.4e-47 PREDICTED: LOW QUALITY PROTEIN: estrogen sulfotransferase [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q3UZZ6 271 3.6e-22 Sulfotransferase 1 family member D1 OS=Mus musculus GN=Sult1d1 PE=1 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.58592 BP_3 89.04 1.12 4121 642939403 XP_008193263.1 1963 6.4e-217 PREDICTED: protein FAM135A [Tribolium castaneum]>gi|270016463|gb|EFA12909.1| hypothetical protein TcasGA2_TC006979 [Tribolium castaneum] 642939402 XM_008195041.1 369 0 PREDICTED: Tribolium castaneum protein FAM135A (LOC661082), mRNA -- -- -- -- Q5RA75 1083 2.9e-116 Protein FAM135A OS=Pongo abelii GN=FAM135A PE=2 SV=1 PF07819 PGAP1-like protein GO:0006886//GO:0006505 intracellular protein transport//GPI anchor metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2205 Uncharacterized conserved protein Cluster-8309.58594 BP_3 52.66 2.68 1240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58595 BP_3 34.34 1.72 1254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58597 BP_3 40.04 3.84 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58598 BP_3 123.00 2.18 3016 322793445 EFZ17004.1 911 4.5e-95 hypothetical protein SINV_11875, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.5860 BP_3 1.00 0.36 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58604 BP_3 50.00 1.81 1625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58605 BP_3 727.06 12.33 3133 91085213 XP_972338.1 2668 8.6e-299 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009080|gb|EFA05528.1| hypothetical protein TcasGA2_TC015715 [Tribolium castaneum] 817051486 XM_012395873.1 137 9.86587e-63 PREDICTED: Athalia rosae glucose dehydrogenase [FAD, quinone] (LOC105683336), mRNA -- -- -- -- P18172 1195 2.3e-129 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05834//PF07992//PF00732//PF01266//PF05199 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase GO:0055114//GO:0006544//GO:0006566//GO:0016117//GO:0006066//GO:0006563 oxidation-reduction process//glycine metabolic process//threonine metabolic process//carotenoid biosynthetic process//alcohol metabolic process//L-serine metabolic process GO:0008812//GO:0050660//GO:0016491//GO:0016614//GO:0016705 choline dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.58610 BP_3 4.00 0.60 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58611 BP_3 17.16 0.35 2636 21218350 AAM44045.1 1783 3.0e-196 arylphorin-like hexamerin [Apriona germari] -- -- -- -- -- -- -- -- -- Q17127 976 4.7e-104 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58614 BP_3 4101.00 116.87 1983 642923075 XP_008193601.1 906 1.1e-94 PREDICTED: uncharacterized protein LOC655361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VBV3 176 2.1e-11 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58618 BP_3 2745.00 99.16 1626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0051536//GO:0009055 iron-sulfur cluster binding//electron carrier activity -- -- -- -- Cluster-8309.58620 BP_3 12.97 0.33 2203 270001355 EEZ97802.1 1865 7.9e-206 hypothetical protein TcasGA2_TC000164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UI26 1020 3.1e-109 Importin-11 OS=Homo sapiens GN=IPO11 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) Cluster-8309.58623 BP_3 36.30 0.45 4176 560124991 CDJ90379.1 524 4.7e-50 uncharacterized protein LOC100903664 [Haemonchus contortus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05970 PIF1-like helicase GO:0006281//GO:0000723 DNA repair//telomere maintenance GO:0003678 DNA helicase activity GO:0005657 replication fork -- -- Cluster-8309.58628 BP_3 88.30 1.29 3588 642917912 XP_008191379.1 989 4.9e-104 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 531 2.6e-52 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04587//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//ADP-specific Phosphofructokinase/Glucokinase conserved region//Glycosyltransferase family 28 C-terminal domain GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0016758//GO:0016773 transferase activity, transferring hexosyl groups//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.5863 BP_3 14.35 0.83 1124 642912538 XP_008200905.1 283 1.1e-22 PREDICTED: uncharacterized protein LOC103315037 [Tribolium castaneum]>gi|270002598|gb|EEZ99045.1| hypothetical protein TcasGA2_TC004919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58631 BP_3 29.68 0.63 2559 642934168 XP_008199635.1 1369 3.0e-148 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.85547e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 O95352 1082 2.3e-116 Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1 PF13241//PF00899//PF02826//PF02558 Putative NAD(P)-binding//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Ketopantoate reductase PanE/ApbA GO:0055114//GO:0006779//GO:0019354//GO:0015940 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//pantothenate biosynthetic process GO:0008677//GO:0008641//GO:0043115//GO:0051287 2-dehydropantoate 2-reductase activity//small protein activating enzyme activity//precorrin-2 dehydrogenase activity//NAD binding -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.58632 BP_3 367.00 9.94 2071 642933652 XP_975152.2 513 4.4e-49 PREDICTED: nucleoporin-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RB98 180 7.4e-12 Nucleoporin-like protein 2 OS=Pongo abelii GN=NUPL2 PE=2 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.58633 BP_3 157.39 3.86 2258 780633762 XP_011686120.1 148 1.0e-06 PREDICTED: uncharacterized protein LOC105448935 isoform X1 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08468 Methyltransferase small domain N-terminal GO:0006364//GO:0006396//GO:0000154 rRNA processing//RNA processing//rRNA modification GO:0008990 rRNA (guanine-N2-)-methyltransferase activity -- -- -- -- Cluster-8309.58636 BP_3 40.05 0.83 2609 478261443 ENN80813.1 1051 2.3e-111 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] 462382197 APGK01021748.1 104 1.81359e-44 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 675 3.7e-69 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.58642 BP_3 26.25 2.75 752 642933131 XP_008197270.1 271 1.8e-21 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58643 BP_3 5.00 0.42 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58644 BP_3 19.00 1.58 870 765166498 XP_011492063.1 340 2.1e-29 PREDICTED: gastrula zinc finger protein XlCGF28.1-like isoform X4 [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 326 3.7e-29 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF02892//PF04810//PF13912//PF01525//PF00096//PF13465 BED zinc finger//Sec23/Sec24 zinc finger//C2H2-type zinc finger//Rotavirus NS26//Zinc finger, C2H2 type//Zinc-finger double domain GO:0019079//GO:0006886//GO:0006888 viral genome replication//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0003677//GO:0008270//GO:0016887//GO:0046872//GO:0000287 DNA binding//zinc ion binding//ATPase activity//metal ion binding//magnesium ion binding GO:0030127//GO:0030430 COPII vesicle coat//host cell cytoplasm -- -- Cluster-8309.58646 BP_3 362.97 3.06 6006 642929078 XP_008195682.1 1247 9.9e-134 PREDICTED: venom metalloproteinase 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01562 Reprolysin family propeptide GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.58655 BP_3 374.96 16.09 1415 642926052 XP_970129.2 706 1.3e-71 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49638 232 4.7e-18 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 PF06466//PF12464 PCAF (P300/CBP-associated factor) N-terminal domain//Maltose acetyltransferase GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0016407//GO:0004402 acetyltransferase activity//histone acetyltransferase activity GO:0005634//GO:0000123 nucleus//histone acetyltransferase complex -- -- Cluster-8309.58656 BP_3 3387.62 37.66 4627 642924185 XP_008194188.1 6346 0.0e+00 PREDICTED: chitin synthase 1 isoform X1 [Tribolium castaneum]>gi|33867317|gb|AAQ55059.1| chitin synthase CHS1A [Tribolium castaneum]>gi|34148367|gb|AAQ62693.1| chitin synthase variant 1 [Tribolium castaneum] 627401361 KF147149.1 1249 0 Anthonomus grandis chitin synthase I (CHS1) mRNA, complete cds K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q4P9K9 230 2.6e-17 Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=CHS8 PE=3 SV=1 PF04277//PF04689 Oxaloacetate decarboxylase, gamma chain//DNA binding protein S1FA GO:0006525//GO:0006560//GO:0006814//GO:0006355//GO:0006090//GO:0071436//GO:0006031 arginine metabolic process//proline metabolic process//sodium ion transport//regulation of transcription, DNA-templated//pyruvate metabolic process//sodium ion export//chitin biosynthetic process GO:0003677//GO:0004100//GO:0008948//GO:0015081 DNA binding//chitin synthase activity//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0005634//GO:0016020 nucleus//membrane KOG2571 Chitin synthase/hyaluronan synthase (glycosyltransferases) Cluster-8309.58658 BP_3 2.00 0.77 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58659 BP_3 11.96 0.80 1011 189235061 XP_001814285.1 1028 4.1e-109 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2J8 292 3.7e-25 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- -- -- Cluster-8309.58661 BP_3 58.27 1.52 2136 642931115 XP_008201667.1 573 5.0e-56 PREDICTED: autism susceptibility gene 2 protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58666 BP_3 244.00 8.30 1708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58668 BP_3 56.77 2.74 1292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58671 BP_3 846.08 13.88 3229 642925584 XP_008194609.1 2730 5.8e-306 PREDICTED: LOW QUALITY PROTEIN: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 502 5.3e-49 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF05434//PF01757 TMEM9//Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016021 integral component of membrane -- -- Cluster-8309.58677 BP_3 28.12 0.75 2093 270013573 EFA10021.1 936 4.0e-98 hypothetical protein TcasGA2_TC012193 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58678 BP_3 175.25 2.78 3334 270013573 EFA10021.1 1066 5.3e-113 hypothetical protein TcasGA2_TC012193 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06384//PF00503//PF08558//PF01580//PF02367//PF00004//PF00735//PF08477//PF01926//PF00158//PF00493//PF04548//PF00910//PF03193//PF00005//PF00437//PF05049 Beta-catenin-interacting protein ICAT//G-protein alpha subunit//Telomere repeat binding factor (TRF)//FtsK/SpoIIIE family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Sigma-54 interaction domain//MCM2/3/5 family//AIG1 family//RNA helicase//Protein of unknown function, DUF258//ABC transporter//Type II/IV secretion system protein//Interferon-inducible GTPase (IIGP) GO:0006260//GO:0007186//GO:0006355//GO:0007165//GO:0006810//GO:0002949//GO:0007264 DNA replication//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//signal transduction//transport//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0016887//GO:0019001//GO:0008013//GO:0000166//GO:0031683//GO:0005524//GO:0008134//GO:0042162//GO:0003924//GO:0004871//GO:0042803//GO:0005525//GO:0003724//GO:0003677//GO:0003723 ATPase activity//guanyl nucleotide binding//beta-catenin binding//nucleotide binding//G-protein beta/gamma-subunit complex binding//ATP binding//transcription factor binding//telomeric DNA binding//GTPase activity//signal transducer activity//protein homodimerization activity//GTP binding//RNA helicase activity//DNA binding//RNA binding GO:0016342//GO:0016020//GO:0005667 catenin complex//membrane//transcription factor complex -- -- Cluster-8309.58680 BP_3 396.20 3.85 5251 429544803 AGA01579.1 2323 1.5e-258 cryptochrome 2 [Rhyparobia maderae] 801397565 XM_012203803.1 258 9.05564e-130 PREDICTED: Atta cephalotes cryptochrome-1-like (LOC105622379), mRNA K02295 CRY cryptochrome http://www.genome.jp/dbget-bin/www_bget?ko:K02295 P97784 1966 1.5e-218 Cryptochrome-1 OS=Mus musculus GN=Cry1 PE=1 SV=1 PF16622//PF13912//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG0133 Deoxyribodipyrimidine photolyase/cryptochrome Cluster-8309.58683 BP_3 18.48 0.40 2545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58686 BP_3 8.25 4.30 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03874//PF00484 RNA polymerase Rpb4//Carbonic anhydrase GO:0006144//GO:0006351//GO:0006807//GO:0006206//GO:0006730 purine nucleobase metabolic process//transcription, DNA-templated//nitrogen compound metabolic process//pyrimidine nucleobase metabolic process//one-carbon metabolic process GO:0004089//GO:0003899//GO:0008270 carbonate dehydratase activity//DNA-directed RNA polymerase activity//zinc ion binding GO:0005730 nucleolus -- -- Cluster-8309.58687 BP_3 11.98 0.52 1406 642910370 XP_008200295.1 999 1.3e-105 PREDICTED: kinesin-like protein KIF12 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXL2 295 2.3e-25 Kinesin-like protein KIF21A OS=Mus musculus GN=Kif21a PE=1 SV=2 PF00225//PF04977//PF02183//PF00170 Kinesin motor domain//Septum formation initiator//Homeobox associated leucine zipper//bZIP transcription factor GO:0006355//GO:0007017//GO:0007049//GO:0007018 regulation of transcription, DNA-templated//microtubule-based process//cell cycle//microtubule-based movement GO:0008017//GO:0043565//GO:0003700//GO:0005524//GO:0003777 microtubule binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//ATP binding//microtubule motor activity GO:0045298//GO:0005667//GO:0005874 tubulin complex//transcription factor complex//microtubule KOG0244 Kinesin-like protein Cluster-8309.58690 BP_3 4.04 0.48 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58691 BP_3 26.33 1.18 1363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58693 BP_3 71.61 0.70 5247 642929943 XP_008196036.1 677 1.1e-67 PREDICTED: microtubule-associated protein futsch-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q767L8 268 1.2e-21 Mediator of DNA damage checkpoint protein 1 OS=Sus scrofa GN=MDC1 PE=3 SV=1 PF01734//PF00498 Patatin-like phospholipase//FHA domain GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.58697 BP_3 37.50 0.89 2325 270013369 EFA09817.1 200 9.7e-13 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58700 BP_3 2.00 0.36 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58703 BP_3 63.04 0.96 3458 768432767 XP_011557722.1 148 1.5e-06 PREDICTED: uncharacterized protein LOC105388496 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58708 BP_3 47.11 0.90 2824 91077490 XP_968878.1 1686 5.8e-185 PREDICTED: protein downstream neighbor of son homolog [Tribolium castaneum]>gi|270002143|gb|EEZ98590.1| hypothetical protein TcasGA2_TC001105 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNA8 789 2.4e-82 Protein downstream neighbor of son homolog OS=Drosophila melanogaster GN=hd PE=1 SV=1 PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- KOG4734 Uncharacterized conserved protein Cluster-8309.58709 BP_3 255.89 4.97 2774 91077490 XP_968878.1 1686 5.7e-185 PREDICTED: protein downstream neighbor of son homolog [Tribolium castaneum]>gi|270002143|gb|EEZ98590.1| hypothetical protein TcasGA2_TC001105 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNA8 789 2.4e-82 Protein downstream neighbor of son homolog OS=Drosophila melanogaster GN=hd PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4734 Uncharacterized conserved protein Cluster-8309.58711 BP_3 51.00 3.85 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58712 BP_3 14.89 0.97 1029 546679816 ERL90208.1 593 1.2e-58 hypothetical protein D910_07562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 504 9.9e-50 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF13304//PF00664 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.58716 BP_3 12.89 1.09 863 91083843 XP_973852.1 445 1.4e-41 PREDICTED: larval cuticle protein LCP-30 [Tribolium castaneum]>gi|270006765|gb|EFA03213.1| hypothetical protein TcasGA2_TC013133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08738 259 2.1e-21 Larval cuticle protein LCP-30 OS=Bombyx mori GN=LCP30 PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.58719 BP_3 16.00 203.27 237 642930000 XP_008196060.1 223 2.1e-16 PREDICTED: calphotin [Tribolium castaneum] 183979295 AB264688.1 72 8.84167e-28 Papilio xuthus PxutCPR67Bc mRNA for cuticular protein CPR67Bc, complete cds, clone: Psg27 -- -- -- -- Q17015 203 1.8e-15 Cuticle protein OS=Anopheles gambiae GN=Ccp84Ab PE=2 SV=3 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.5872 BP_3 28.53 0.62 2498 675378173 KFM71075.1 685 6.0e-69 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01671 African swine fever virus multigene family 360 protein GO:0042330 taxis -- -- -- -- -- -- Cluster-8309.58720 BP_3 15.00 35.05 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58722 BP_3 16.00 1.17 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58727 BP_3 21.70 2.82 663 642916479 XP_008191061.1 390 2.6e-35 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17FR9 195 4.3e-14 Serrate RNA effector molecule homolog OS=Aedes aegypti GN=Ars2 PE=3 SV=1 -- -- -- -- GO:0000166 nucleotide binding -- -- -- -- Cluster-8309.58728 BP_3 33.85 0.42 4211 642912795 XP_008201255.1 1623 1.7e-177 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 353 1.3e-31 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.58729 BP_3 14.00 1.71 687 546674048 ERL85536.1 259 4.1e-20 hypothetical protein D910_02955, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58730 BP_3 4.00 0.56 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58731 BP_3 1017.48 6.80 7503 642915658 XP_008190700.1 5670 0.0e+00 PREDICTED: nephrin isoform X1 [Tribolium castaneum]>gi|642915662|ref|XP_008190702.1| PREDICTED: nephrin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZS7 1262 9.2e-137 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF13895//PF00041//PF05434 Immunoglobulin domain//Fibronectin type III domain//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules Cluster-8309.58734 BP_3 35.67 0.93 2147 642122061 CDQ63792.1 197 2.0e-12 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14372//PF02083 Domain of unknown function (DUF4413)//Urotensin II GO:0007165//GO:0042312//GO:0008217 signal transduction//regulation of vasodilation//regulation of blood pressure GO:0005179//GO:0003677 hormone activity//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.58739 BP_3 101.52 1.89 2884 270003148 EEZ99595.1 382 9.5e-34 hypothetical protein TcasGA2_TC001582 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58740 BP_3 210.00 166.41 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58741 BP_3 406.76 6.29 3409 91087301 XP_975566.1 1257 3.9e-135 PREDICTED: uncharacterized protein LOC664468 isoform X1 [Tribolium castaneum] 642929774 XM_008197747.1 105 6.60561e-45 PREDICTED: Tribolium castaneum uncharacterized LOC664468 (LOC664468), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58742 BP_3 33.94 0.33 5184 270013369 EFA09817.1 788 1.4e-80 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- K17963 PPRC1, PRC peroxisome proliferator-activated receptor gamma coactivator-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17963 Q5VV67 169 3.5e-10 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Homo sapiens GN=PPRC1 PE=1 SV=1 PF00076//PF15305 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Intraflagellar transport protein 43 -- -- GO:0003676 nucleic acid binding GO:0030991 intraciliary transport particle A -- -- Cluster-8309.58751 BP_3 152.00 22.32 620 817212368 XP_012282361.1 341 1.2e-29 PREDICTED: endocuticle structural glycoprotein SgAbd-1-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q7M4F4 264 4.0e-22 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.58762 BP_3 107.16 1.22 4509 642919898 XP_008192116.1 1398 2.3e-151 PREDICTED: mucin-17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58764 BP_3 27.22 0.65 2299 642937440 XP_008198835.1 236 6.4e-17 PREDICTED: uncharacterized protein LOC103314468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04825 N terminus of Rad21 / Rec8 like protein -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.58767 BP_3 396.84 3.77 5359 512921142 XP_004929807.1 2290 1.0e-254 PREDICTED: bestrophin-4 isoform X2 [Bombyx mori] 644995962 XM_001603356.3 234 2.02931e-116 PREDICTED: Nasonia vitripennis putative lysozyme-like protein (LOC100119673), transcript variant X1, mRNA -- -- -- -- Q6H1V1 898 1.1e-94 Bestrophin-3 OS=Mus musculus GN=Best3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.58772 BP_3 971.73 12.57 4018 762120734 XP_011443287.1 442 1.5e-40 PREDICTED: collagen alpha-1(III) chain-like isoform X4 [Crassostrea gigas] 170039347 XM_001847447.1 45 1.76122e-11 Culex quinquefasciatus collagen alpha 1(XVIII) chain, mRNA K08135 COL15A collagen, type XV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08135 P02453 359 2.5e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF06482//PF10660 Collagenase NC10 and Endostatin//Iron-containing outer mitochondrial membrane protein N-terminus GO:0007155 cell adhesion GO:0051537//GO:0005198 2 iron, 2 sulfur cluster binding//structural molecule activity GO:0031012//GO:0043231 extracellular matrix//intracellular membrane-bounded organelle -- -- Cluster-8309.58773 BP_3 122.54 1.91 3392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58774 BP_3 22.56 0.60 2119 478252836 ENN73225.1 1180 2.0e-126 hypothetical protein YQE_10122, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14102 Capsule biosynthesis CapC GO:0045227 capsule polysaccharide biosynthetic process -- -- GO:0016020 membrane -- -- Cluster-8309.58775 BP_3 1.73 0.35 529 546675359 ERL86569.1 338 2.2e-29 hypothetical protein D910_03976 [Dendroctonus ponderosae] -- -- -- -- -- K12345 SRD5A3 3-oxo-5-alpha-steroid 4-dehydrogenase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12345 Q9VLP9 212 3.7e-16 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0005737//GO:0016021 cytoplasm//integral component of membrane KOG1640 Predicted steroid reductase Cluster-8309.58779 BP_3 90.59 2.82 1840 260802183 XP_002595972.1 180 1.6e-10 hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae]>gi|229281225|gb|EEN51984.1| hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9PVG3 128 7.1e-06 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF13465//PF00096//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.58780 BP_3 64.41 1.94 1890 260802183 XP_002595972.1 180 1.6e-10 hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae]>gi|229281225|gb|EEN51984.1| hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9PVG3 128 7.3e-06 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF01363//PF07776//PF00096//PF13465 FYVE zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.58781 BP_3 2.33 3.39 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58783 BP_3 24.00 0.44 2900 642921027 XP_008192660.1 1943 9.4e-215 PREDICTED: protein kinase C-binding protein NELL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92832 889 6.4e-94 Protein kinase C-binding protein NELL1 OS=Homo sapiens GN=NELL1 PE=1 SV=4 PF07645//PF00008//PF00093 Calcium-binding EGF domain//EGF-like domain//von Willebrand factor type C domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.58788 BP_3 12.53 1.31 754 21669483 BAC01766.1 885 1.2e-92 immunoglobulin kappa light chain VLJ region [Homo sapiens] 49256424 BC073764.1 700 0 Homo sapiens immunoglobulin kappa constant, mRNA (cDNA clone IMAGE:4576136) -- -- -- -- P01834 482 2.6e-47 Ig kappa chain C region OS=Homo sapiens GN=IGKC PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58789 BP_3 47.50 0.51 4808 270015460 EFA11908.1 2570 3.1e-287 hypothetical protein TcasGA2_TC004065 [Tribolium castaneum] 805759873 XM_012297744.1 247 1.07952e-123 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 2.0e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00018//PF14604//PF00621 SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.58792 BP_3 1438.00 42.41 1926 817076821 XP_012260705.1 1285 1.2e-138 PREDICTED: low-density lipoprotein receptor-related protein [Athalia rosae] -- -- -- -- -- -- -- -- -- P20063 332 1.6e-29 Low-density lipoprotein receptor (Fragment) OS=Oryctolagus cuniculus GN=LDLR PE=2 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.58794 BP_3 9.00 1.09 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58795 BP_3 12.00 0.39 1765 676439202 XP_009048780.1 1450 8.4e-158 hypothetical protein LOTGIDRAFT_177987 [Lottia gigantea]>gi|556112009|gb|ESP00661.1| hypothetical protein LOTGIDRAFT_177987 [Lottia gigantea] 697086849 XM_009658042.1 1553 0 Verticillium dahliae VdLs.17 aldehyde dehydrogenase partial mRNA K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P40108 1987 1.9e-221 Aldehyde dehydrogenase OS=Davidiella tassiana GN=CLAH10 PE=1 SV=2 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.58799 BP_3 24.72 0.61 2236 270009006 EFA05454.1 244 7.4e-18 hypothetical protein TcasGA2_TC015635 [Tribolium castaneum] -- -- -- -- -- K14995 SLC38A9 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14995 Q19425 150 2.4e-08 Sodium-coupled neutral amino acid transporter 9 homolog OS=Caenorhabditis elegans GN=F13H10.3 PE=3 SV=2 PF06621 Single-minded protein C-terminus GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.58800 BP_3 4.33 3.25 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00374 Nickel-dependent hydrogenase -- -- GO:0016151 nickel cation binding -- -- -- -- Cluster-8309.58801 BP_3 15.63 0.92 1108 641667656 XP_008184168.1 175 3.7e-10 PREDICTED: myb/SANT-like DNA-binding domain-containing protein 3 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58805 BP_3 132.18 6.28 1307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07462 Merozoite surface protein 1 (MSP1) C-terminus GO:0009405 pathogenesis -- -- GO:0016020 membrane -- -- Cluster-8309.58808 BP_3 117.93 1.01 5939 91079786 XP_967971.1 1583 1.1e-172 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 1.3e-125 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607 Chitin binding Peritrophin-A domain GO:0006030//GO:0042254//GO:0006396 chitin metabolic process//ribosome biogenesis//RNA processing GO:0003824//GO:0008061 catalytic activity//chitin binding GO:0005576//GO:0005730 extracellular region//nucleolus KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.58809 BP_3 495.61 6.24 4122 91079786 XP_967971.1 1583 7.4e-173 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 9.0e-126 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607 Chitin binding Peritrophin-A domain GO:0006396//GO:0042254//GO:0006030 RNA processing//ribosome biogenesis//chitin metabolic process GO:0008061//GO:0003824 chitin binding//catalytic activity GO:0005730//GO:0005576 nucleolus//extracellular region KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.5881 BP_3 101.96 3.44 1720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58810 BP_3 76.44 0.84 4689 91079786 XP_967971.1 1583 8.4e-173 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 1.0e-125 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607 Chitin binding Peritrophin-A domain GO:0006030//GO:0006396//GO:0042254 chitin metabolic process//RNA processing//ribosome biogenesis GO:0003824//GO:0008061 catalytic activity//chitin binding GO:0005576//GO:0005730 extracellular region//nucleolus KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.58811 BP_3 158.00 3.88 2257 642917599 XP_008191274.1 335 2.1e-28 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTC2 143 1.6e-07 Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Drosophila melanogaster GN=blos4 PE=1 SV=1 PF16519//PF01496//PF08651//PF02609//PF06009//PF05531//PF07464 Tetramerisation domain of TRPM//V-type ATPase 116kDa subunit family//DASH complex subunit Duo1//Exonuclease VII small subunit//Laminin Domain II//Nucleopolyhedrovirus P10 protein//Apolipophorin-III precursor (apoLp-III) GO:0006869//GO:0015991//GO:0006308//GO:0007155//GO:0051262//GO:0015992//GO:0007067 lipid transport//ATP hydrolysis coupled proton transport//DNA catabolic process//cell adhesion//protein tetramerization//proton transport//mitotic nuclear division GO:0008855//GO:0008289//GO:0015078 exodeoxyribonuclease VII activity//lipid binding//hydrogen ion transmembrane transporter activity GO:0072686//GO:0033179//GO:0005576//GO:0019028//GO:0009318//GO:0042729 mitotic spindle//proton-transporting V-type ATPase, V0 domain//extracellular region//viral capsid//exodeoxyribonuclease VII complex//DASH complex -- -- Cluster-8309.58812 BP_3 22.21 1.48 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58813 BP_3 294.17 3.72 4104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF07776 THAP domain//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.58814 BP_3 120.84 1.51 4152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF05485 Zinc-finger associated domain (zf-AD)//THAP domain -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.58824 BP_3 64.38 1.11 3079 642917749 XP_008191355.1 2991 0.0e+00 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q179T2 933 5.3e-99 Exonuclease mut-7 homolog OS=Aedes aegypti GN=AAEL005527 PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- KOG4373 Predicted 3'-5' exonuclease Cluster-8309.58830 BP_3 11.70 0.33 1983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58831 BP_3 82.50 1.31 3336 642935746 XP_008198156.1 478 8.1e-45 PREDICTED: putative odorant receptor 71a [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46077 161 1.9e-09 Odorant receptor 2a OS=Drosophila melanogaster GN=Or2a PE=2 SV=2 PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.58833 BP_3 81.97 3.00 1607 270014352 EFA10800.1 441 7.6e-41 odorant receptor 64 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V6H2 145 6.6e-08 Odorant receptor 49b OS=Drosophila melanogaster GN=Or49b PE=2 SV=1 PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.58837 BP_3 138.17 1.39 5077 642925869 XP_008190626.1 2127 7.6e-236 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 Q9P2N4 1060 1.7e-113 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF01562//PF00413//PF01421 Reprolysin family propeptide//Matrixin//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.58839 BP_3 136.90 4.51 1755 91077290 XP_974504.1 303 8.4e-25 PREDICTED: synaptonemal complex protein 1 [Tribolium castaneum]>gi|270002764|gb|EEZ99211.1| IKK gamma [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08799 163 5.9e-10 Myosin-2 heavy chain OS=Dictyostelium discoideum GN=mhcA PE=1 SV=3 PF13851//PF00096//PF00038//PF03836//PF13912 Growth-arrest specific micro-tubule binding//Zinc finger, C2H2 type//Intermediate filament protein//RasGAP C-terminus//C2H2-type zinc finger GO:0007264//GO:0048870 small GTPase mediated signal transduction//cell motility GO:0005198//GO:0046872//GO:0005096 structural molecule activity//metal ion binding//GTPase activator activity GO:0005882//GO:0031514 intermediate filament//motile cilium -- -- Cluster-8309.5884 BP_3 12.39 0.57 1336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58841 BP_3 338.72 34.64 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58844 BP_3 20.55 3.01 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58849 BP_3 27.56 0.72 2135 642932631 XP_008196927.1 1581 6.5e-173 PREDICTED: runt-related transcription factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08775 186 1.5e-12 Runt-related transcription factor 2 OS=Mus musculus GN=Runx2 PE=1 SV=2 PF00853 Runt domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.5885 BP_3 25.68 0.69 2079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58851 BP_3 20.44 0.84 1459 189237508 XP_972374.2 348 4.2e-30 PREDICTED: protein D2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 268 3.3e-22 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.58856 BP_3 92.55 1.09 4397 194035591 XP_001927046.1 416 1.7e-37 PREDICTED: zinc finger protein 572 isoform X1 [Sus scrofa]>gi|545820174|ref|XP_005662915.1| PREDICTED: zinc finger protein 572 isoform X2 [Sus scrofa] 642938625 XM_008203027.1 543 0 PREDICTED: Tribolium castaneum zinc finger protein rotund-like (LOC659822), transcript variant X4, mRNA -- -- -- -- Q32KN0 405 1.3e-37 Zinc finger protein 572 OS=Bos taurus GN=ZNF572 PE=2 SV=1 PF16622//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.58857 BP_3 4.06 0.92 505 270007742 EFA04190.1 257 5.2e-20 hypothetical protein TcasGA2_TC014439 [Tribolium castaneum] 642923854 XM_008195685.1 70 2.64631e-26 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58858 BP_3 114.00 7.59 1016 546683448 ERL93254.1 356 3.5e-31 hypothetical protein D910_10550 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5886 BP_3 15.56 2.24 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58860 BP_3 1.00 2.07 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58862 BP_3 35.54 0.31 5907 817212181 XP_012282266.1 2749 6.6e-308 PREDICTED: uncharacterized protein LOC105700713 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17121 Zinc finger, C3HC4 type (RING finger) -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.58863 BP_3 8.00 0.42 1215 332249303 XP_003273803.1 1325 1.8e-143 PREDICTED: triosephosphate isomerase isoform X1 [Nomascus leucogenys] 226529916 NM_001159287.1 1215 0 Homo sapiens triosephosphate isomerase 1 (TPI1), transcript variant 2, mRNA K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P60174 1325 7.4e-145 Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=3 PF06883//PF00121 RNA polymerase I, Rpa2 specific domain//Triosephosphate isomerase GO:0006351//GO:0006096//GO:0008152//GO:0006144//GO:0006020//GO:0015976//GO:0006094//GO:0006206//GO:0006013//GO:0006000//GO:0046486 transcription, DNA-templated//glycolytic process//metabolic process//purine nucleobase metabolic process//inositol metabolic process//carbon utilization//gluconeogenesis//pyrimidine nucleobase metabolic process//mannose metabolic process//fructose metabolic process//glycerolipid metabolic process GO:0004807//GO:0003899 triose-phosphate isomerase activity//DNA-directed RNA polymerase activity GO:0005634//GO:0005730 nucleus//nucleolus KOG1643 Triosephosphate isomerase Cluster-8309.58864 BP_3 78.66 3.61 1342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02970//PF04111//PF03153 Tubulin binding cofactor A//Autophagy protein Apg6//Transcription factor IIA, alpha/beta subunit GO:0006367//GO:0006914//GO:0007021 transcription initiation from RNA polymerase II promoter//autophagy//tubulin complex assembly GO:0015631//GO:0051082 tubulin binding//unfolded protein binding GO:0045298//GO:0005672 tubulin complex//transcription factor TFIIA complex -- -- Cluster-8309.58866 BP_3 136.00 12.18 830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58869 BP_3 227.08 9.00 1508 642936055 XP_008198283.1 814 4.0e-84 PREDICTED: fringe glycosyltransferase [Tribolium castaneum]>gi|270013211|gb|EFA09659.1| hypothetical protein TcasGA2_TC011785 [Tribolium castaneum] -- -- -- -- -- K05948 FNG fringe http://www.genome.jp/dbget-bin/www_bget?ko:K05948 Q24342 679 7.4e-70 Fringe glycosyltransferase OS=Drosophila melanogaster GN=fng PE=1 SV=1 PF02434 Fringe-like -- -- GO:0016757 transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.58870 BP_3 9.19 0.55 1091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58873 BP_3 34.56 1.32 1552 478252267 ENN72695.1 178 2.3e-10 hypothetical protein YQE_10790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V7U0 155 4.4e-09 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58875 BP_3 609.00 18.81 1852 642939050 XP_001810713.2 365 5.7e-32 PREDICTED: uncharacterized protein LOC100142323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58877 BP_3 8.00 0.47 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58879 BP_3 3.00 1.47 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58884 BP_3 37.35 0.45 4261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58886 BP_3 19.50 0.45 2383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5889 BP_3 3.74 0.41 732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58896 BP_3 4.00 2.02 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58898 BP_3 7.00 1.05 613 478253101 ENN73474.1 188 6.3e-12 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58899 BP_3 5.00 0.98 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5890 BP_3 8.85 1.06 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00729 Viral coat protein (S domain) -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.58904 BP_3 108.73 2.95 2068 91092792 XP_974059.1 1716 1.4e-188 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|642911515|ref|XP_008199454.1| PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|270014784|gb|EFA11232.1| hypothetical protein TcasGA2_TC010764 [Tribolium castaneum] 462386156 APGK01020335.1 242 2.76879e-121 Dendroctonus ponderosae Seq01020345, whole genome shotgun sequence K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1089 2.9e-117 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF02949 Divalent cation transporter//7tm Odorant receptor GO:0007187//GO:0006812//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//cation transport//sensory perception of smell GO:0008324//GO:0004984//GO:0005549 cation transmembrane transporter activity//olfactory receptor activity//odorant binding GO:0016020 membrane KOG3788 Predicted divalent cation transporter Cluster-8309.58905 BP_3 117.27 3.46 1926 91092792 XP_974059.1 1716 1.3e-188 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|642911515|ref|XP_008199454.1| PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|270014784|gb|EFA11232.1| hypothetical protein TcasGA2_TC010764 [Tribolium castaneum] 462386156 APGK01020335.1 242 2.57539e-121 Dendroctonus ponderosae Seq01020345, whole genome shotgun sequence K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1089 2.7e-117 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF02949 Divalent cation transporter//7tm Odorant receptor GO:0007187//GO:0006812//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//cation transport//sensory perception of smell GO:0008324//GO:0004984//GO:0005549 cation transmembrane transporter activity//olfactory receptor activity//odorant binding GO:0016020 membrane KOG3788 Predicted divalent cation transporter Cluster-8309.58907 BP_3 54.43 1.15 2581 121582324 NP_001073566.1 334 3.1e-28 cuticular protein analogous to peritrophins 3-B precursor [Tribolium castaneum]>gi|119387886|gb|ABL73928.1| obstractor B [Tribolium castaneum]>gi|270000881|gb|EEZ97328.1| hypothetical protein TcasGA2_TC011139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.58908 BP_3 220.60 1.77 6288 242005002 XP_002423364.1 1694 1.5e-185 hormone receptor hr3, putative [Pediculus humanus corporis]>gi|212506394|gb|EEB10626.1| hormone receptor hr3, putative [Pediculus humanus corporis] 642929407 XM_008197603.1 666 0 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X3, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P31396 730 3.8e-75 Probable nuclear hormone receptor HR3 OS=Drosophila melanogaster GN=Hr46 PE=2 SV=1 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0009987//GO:0043401//GO:0006355 cellular process//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0005488//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4216 Steroid hormone nuclear receptor Cluster-8309.58911 BP_3 13.34 0.38 1989 642938002 XP_008199166.1 331 5.4e-28 PREDICTED: uncharacterized protein LOC103314560 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83120 171 7.9e-11 G-protein coupled receptor Mth OS=Drosophila simulans GN=mth PE=3 SV=2 PF00002//PF06652 7 transmembrane receptor (Secretin family)//Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.58916 BP_3 62.60 0.91 3593 641663663 XP_008182723.1 1405 2.8e-152 PREDICTED: uncharacterized protein LOC103309327 [Acyrthosiphon pisum]>gi|641679805|ref|XP_008188719.1| PREDICTED: uncharacterized protein LOC103310986 [Acyrthosiphon pisum] 641663662 XM_008184501.1 538 0 PREDICTED: Acyrthosiphon pisum uncharacterized LOC103309327 (LOC103309327), mRNA >gnl|BL_ORD_ID|19443021 PREDICTED: Acyrthosiphon pisum uncharacterized LOC103310986 (LOC103310986), mRNA -- -- -- -- -- -- -- -- PF04827//PF02944 Plant transposon protein//BESS motif -- -- GO:0016788//GO:0003677 hydrolase activity, acting on ester bonds//DNA binding -- -- -- -- Cluster-8309.58920 BP_3 418.90 36.43 846 768411843 XP_011565977.1 368 1.2e-32 PREDICTED: protein yellow [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q9BI23 156 1.8e-09 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58922 BP_3 36.59 0.59 3262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58924 BP_3 77.94 1.32 3139 546685576 ERL95063.1 2573 9.0e-288 hypothetical protein D910_12333 [Dendroctonus ponderosae] 564241862 XM_006277680.1 37 3.84299e-07 PREDICTED: Alligator mississippiensis REV1, polymerase (DNA directed) (REV1), transcript variant X3, mRNA K03515 REV1 DNA repair protein REV1 http://www.genome.jp/dbget-bin/www_bget?ko:K03515 Q4KWZ7 1026 9.0e-110 DNA repair protein REV1 OS=Gallus gallus GN=REV1 PE=2 SV=1 PF11799//PF00961//PF00817//PF03206 impB/mucB/samB family C-terminal domain//LAGLIDADG endonuclease//impB/mucB/samB family//Nitrogen fixation protein NifW GO:0009399//GO:0006281 nitrogen fixation//DNA repair GO:0004519//GO:0003684 endonuclease activity//damaged DNA binding -- -- KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase Cluster-8309.58929 BP_3 5.00 0.43 849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58930 BP_3 139.57 2.72 2766 91078378 XP_974191.1 3075 0.0e+00 PREDICTED: probable leucine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270003885|gb|EFA00333.1| hypothetical protein TcasGA2_TC003172 [Tribolium castaneum] -- -- -- -- -- K01869 LARS, leuS leucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01869 Q5RDP4 1763 2.7e-195 Probable leucine--tRNA ligase, mitochondrial OS=Pongo abelii GN=LARS2 PE=2 SV=1 PF08264//PF03119//PF09334//PF00133//PF13603 Anticodon-binding domain of tRNA//NAD-dependent DNA ligase C4 zinc finger domain//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Leucyl-tRNA synthetase, Domain 2 GO:0006429//GO:0006260//GO:0006418//GO:0006450//GO:0009099//GO:0009098//GO:0009097//GO:0006281 leucyl-tRNA aminoacylation//DNA replication//tRNA aminoacylation for protein translation//regulation of translational fidelity//valine biosynthetic process//leucine biosynthetic process//isoleucine biosynthetic process//DNA repair GO:0000166//GO:0004812//GO:0002161//GO:0003911//GO:0005524//GO:0004823 nucleotide binding//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity//DNA ligase (NAD+) activity//ATP binding//leucine-tRNA ligase activity GO:0005737 cytoplasm KOG0435 Leucyl-tRNA synthetase Cluster-8309.58931 BP_3 96.66 4.00 1456 270003148 EEZ99595.1 382 4.8e-34 hypothetical protein TcasGA2_TC001582 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58935 BP_3 4.00 0.67 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14098 Small, acid-soluble spore protein I GO:0030436 asexual sporulation -- -- -- -- -- -- Cluster-8309.58938 BP_3 10.00 0.75 937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098 C2H2 zinc-finger//Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.58939 BP_3 6.00 0.39 1024 768443194 XP_011563401.1 200 4.3e-13 PREDICTED: homeobox protein 6-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.58940 BP_3 14.00 0.43 1866 805798357 XP_012143825.1 256 2.5e-19 PREDICTED: uncharacterized protein LOC105662855 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58941 BP_3 536.71 6.01 4593 642914198 XP_008201586.1 3974 0.0e+00 PREDICTED: uncharacterized protein LOC661711 isoform X2 [Tribolium castaneum] 642914197 XM_008203364.1 679 0 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.8e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF15360//PF00018//PF04904//PF07647//PF00536 APJ endogenous ligand//SH3 domain//NAB conserved region 1 (NCD1)//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0045892//GO:0007165 negative regulation of transcription, DNA-templated//signal transduction GO:0031704//GO:0005515//GO:0005179 apelin receptor binding//protein binding//hormone activity GO:0005634 nucleus -- -- Cluster-8309.58942 BP_3 98.56 1.60 3252 189235122 XP_001811652.1 2823 0.0e+00 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 412 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1522 2.8e-167 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF00856//PF01496//PF05602//PF05132 SET domain//V-type ATPase 116kDa subunit family//Cleft lip and palate transmembrane protein 1 (CLPTM1)//RNA polymerase III RPC4 GO:0015992//GO:0006206//GO:0015991//GO:0006144//GO:0006383//GO:0006351 proton transport//pyrimidine nucleobase metabolic process//ATP hydrolysis coupled proton transport//purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated GO:0003682//GO:0015078//GO:0003899//GO:0005515//GO:0003677 chromatin binding//hydrogen ion transmembrane transporter activity//DNA-directed RNA polymerase activity//protein binding//DNA binding GO:0005730//GO:0005666//GO:0016021//GO:0033179//GO:0000785 nucleolus//DNA-directed RNA polymerase III complex//integral component of membrane//proton-transporting V-type ATPase, V0 domain//chromatin KOG1079 Transcriptional repressor EZH1 Cluster-8309.58943 BP_3 32.68 0.69 2577 121582324 NP_001073566.1 334 3.1e-28 cuticular protein analogous to peritrophins 3-B precursor [Tribolium castaneum]>gi|119387886|gb|ABL73928.1| obstractor B [Tribolium castaneum]>gi|270000881|gb|EEZ97328.1| hypothetical protein TcasGA2_TC011139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.58944 BP_3 10.39 0.40 1529 270014380 EFA10828.1 618 2.2e-61 hypothetical protein TcasGA2_TC001604 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58945 BP_3 327.18 8.05 2250 817059940 XP_012251499.1 2538 7.4e-284 PREDICTED: sodium-dependent noradrenaline transporter [Athalia rosae] 170049841 XM_001870902.1 357 0 Culex quinquefasciatus norepinephrine/norepinephrine transporter, mRNA K05036 SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine) member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05036 P51143 1799 1.5e-199 Sodium-dependent noradrenaline transporter OS=Bos taurus GN=SLC6A2 PE=2 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3659 Sodium-neurotransmitter symporter Cluster-8309.58947 BP_3 28.73 0.81 2004 270012969 EFA09417.1 2380 1.4e-265 hypothetical protein TcasGA2_TC005219 [Tribolium castaneum] 170049841 XM_001870902.1 357 0 Culex quinquefasciatus norepinephrine/norepinephrine transporter, mRNA K05036 SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine) member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05036 P51143 1599 2.1e-176 Sodium-dependent noradrenaline transporter OS=Bos taurus GN=SLC6A2 PE=2 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3659 Sodium-neurotransmitter symporter Cluster-8309.58948 BP_3 84.00 4.16 1264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58949 BP_3 82.92 0.90 4744 641658099 XP_008180596.1 1075 6.8e-114 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 967 9.4e-103 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF13912//PF00400//PF16622//PF07776//PF13465//PF00096 C2H2-type zinc finger//WD domain, G-beta repeat//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.58951 BP_3 49.00 0.89 2950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58954 BP_3 22.52 0.84 1577 748995278 AJE75661.1 1486 5.0e-162 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09848 1101 9.0e-119 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.58964 BP_3 28.23 0.51 2941 91084525 XP_972529.1 688 3.2e-69 PREDICTED: serine/threonine-protein kinase Chk2 isoform X1 [Tribolium castaneum]>gi|270012661|gb|EFA09109.1| hypothetical protein TcasGA2_TC015484 [Tribolium castaneum] -- -- -- -- -- K06641 CHK2 serine/threonine-protein kinase Chk2 http://www.genome.jp/dbget-bin/www_bget?ko:K06641 Q9Z265 548 2.2e-54 Serine/threonine-protein kinase Chk2 OS=Mus musculus GN=Chek2 PE=1 SV=1 PF05445//PF00498//PF06293//PF00069//PF07714 Poxvirus serine/threonine protein kinase//FHA domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0016772//GO:0005524//GO:0016773 protein binding//protein kinase activity//transferase activity, transferring phosphorus-containing groups//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0615 Serine/threonine protein kinase Chk2 and related proteins Cluster-8309.58965 BP_3 97.37 2.64 2069 91084525 XP_972529.1 881 9.3e-92 PREDICTED: serine/threonine-protein kinase Chk2 isoform X1 [Tribolium castaneum]>gi|270012661|gb|EFA09109.1| hypothetical protein TcasGA2_TC015484 [Tribolium castaneum] -- -- -- -- -- K06641 CHK2 serine/threonine-protein kinase Chk2 http://www.genome.jp/dbget-bin/www_bget?ko:K06641 Q9Z265 734 4.3e-76 Serine/threonine-protein kinase Chk2 OS=Mus musculus GN=Chek2 PE=1 SV=1 PF06293//PF00498//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//FHA domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0005515//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein binding//protein kinase activity GO:0016020 membrane KOG0615 Serine/threonine protein kinase Chk2 and related proteins Cluster-8309.58966 BP_3 10.21 0.58 1147 546680821 ERL91027.1 310 8.4e-26 hypothetical protein D910_08369 [Dendroctonus ponderosae] -- -- -- -- -- K06641 CHK2 serine/threonine-protein kinase Chk2 http://www.genome.jp/dbget-bin/www_bget?ko:K06641 Q9Z265 282 6.1e-24 Serine/threonine-protein kinase Chk2 OS=Mus musculus GN=Chek2 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.58967 BP_3 101.33 2.15 2562 91084525 XP_972529.1 947 2.6e-99 PREDICTED: serine/threonine-protein kinase Chk2 isoform X1 [Tribolium castaneum]>gi|270012661|gb|EFA09109.1| hypothetical protein TcasGA2_TC015484 [Tribolium castaneum] -- -- -- -- -- K06641 CHK2 serine/threonine-protein kinase Chk2 http://www.genome.jp/dbget-bin/www_bget?ko:K06641 O61267 762 3.0e-79 Ovarian-specific serine/threonine-protein kinase Lok OS=Drosophila melanogaster GN=lok PE=2 SV=1 PF07714//PF06293//PF00498//PF00069//PF05445 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//FHA domain//Protein kinase domain//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0005515//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein binding//protein kinase activity GO:0016020 membrane KOG0615 Serine/threonine protein kinase Chk2 and related proteins Cluster-8309.58969 BP_3 3.00 1.45 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58970 BP_3 43.58 1.06 2278 642923025 XP_008200500.1 1848 7.6e-204 PREDICTED: protein eyes shut [Tribolium castaneum]>gi|270006587|gb|EFA03035.1| hypothetical protein TcasGA2_TC010461 [Tribolium castaneum] -- -- -- -- -- K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 A0A1F4 1181 6.9e-128 Protein eyes shut OS=Drosophila melanogaster GN=eys PE=1 SV=1 PF01725//PF00008//PF07645 Ham1 family//EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0016787//GO:0005509 protein binding//hydrolase activity//calcium ion binding -- -- -- -- Cluster-8309.58971 BP_3 5.05 0.94 551 642938331 XP_008192873.1 257 5.6e-20 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58973 BP_3 6.90 0.44 1048 642912076 XP_008200791.1 499 9.3e-48 PREDICTED: U7 snRNA-associated Sm-like protein LSm11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T076 195 6.8e-14 U7 snRNA-associated Sm-like protein LSm11 OS=Xenopus laevis GN=lsm11 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58974 BP_3 32.24 0.72 2440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58975 BP_3 105.49 0.87 6138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58976 BP_3 46.48 0.38 6131 478260451 ENN80177.1 631 2.7e-62 hypothetical protein YQE_03393, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RE88 394 3.4e-36 WD repeat-containing protein 66 OS=Pongo abelii GN=WDR66 PE=2 SV=1 PF13499//PF00758//PF00400 EF-hand domain pair//Erythropoietin/thrombopoietin//WD domain, G-beta repeat GO:0007165 signal transduction GO:0005515//GO:0005179//GO:0005509 protein binding//hormone activity//calcium ion binding GO:0005576 extracellular region -- -- Cluster-8309.58978 BP_3 39.57 0.61 3435 546670638 ERL83322.1 588 1.5e-57 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C6L5 203 2.7e-14 Cyclic GMP-AMP synthase OS=Mus musculus GN=Mb21d1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58979 BP_3 9.66 0.41 1428 499037689 XP_004569491.1 225 7.5e-16 PREDICTED: zinc finger protein 883-like [Maylandia zebra] -- -- -- -- -- K09223 GFI1 growth factor independent 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09223 Q9UL36 206 4.9e-15 Zinc finger protein 236 OS=Homo sapiens GN=ZNF236 PE=2 SV=2 PF02148//PF07503//PF06467//PF00569//PF00096//PF03194//PF02892//PF13912//PF16622//PF00320//PF13465//PF05443 Zn-finger in ubiquitin-hydrolases and other protein//HypF finger//MYM-type Zinc finger with FCS sequence motif//Zinc finger, ZZ type//Zinc finger, C2H2 type//LUC7 N_terminus//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//GATA zinc finger//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein GO:0006376//GO:0006355 mRNA splice site selection//regulation of transcription, DNA-templated GO:0003677//GO:0046872//GO:0003700//GO:0003729//GO:0008270//GO:0043565 DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//mRNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005685 transcription factor complex//U1 snRNP KOG1721 FOG: Zn-finger Cluster-8309.58980 BP_3 4.00 2.84 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58984 BP_3 118.58 3.76 1811 282721120 NP_001164234.1 526 1.2e-50 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V6D6 360 8.7e-33 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0020037//GO:0004497//GO:0005506//GO:0016705//GO:0009055 heme binding//monooxygenase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity -- -- -- -- Cluster-8309.58986 BP_3 259.06 21.74 866 282721120 NP_001164234.1 559 8.5e-55 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V6D6 388 2.4e-36 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0020037//GO:0004497//GO:0005506//GO:0016705//GO:0009055 heme binding//monooxygenase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity -- -- -- -- Cluster-8309.58987 BP_3 303.03 10.44 1691 282721120 NP_001164234.1 1404 1.7e-152 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 978 1.8e-104 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0005506//GO:0020037//GO:0004497 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding//monooxygenase activity -- -- -- -- Cluster-8309.58988 BP_3 215.30 6.90 1796 282721120 NP_001164234.1 1258 1.6e-135 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 883 2.0e-93 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0005506//GO:0020037//GO:0004497//GO:0016705//GO:0009055 iron ion binding//heme binding//monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.58990 BP_3 81.37 2.72 1736 282721120 NP_001164234.1 1378 1.8e-149 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 952 1.9e-101 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0016705//GO:0009055//GO:0005506//GO:0020037//GO:0004497 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity//iron ion binding//heme binding//monooxygenase activity -- -- -- -- Cluster-8309.58991 BP_3 20.36 0.51 2210 270012570 EFA09018.1 599 5.0e-59 hypothetical protein TcasGA2_TC006727 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58995 BP_3 48.00 1.37 1978 873221094 CEM34198.1 699 1.1e-70 unnamed protein product [Vitrella brassicaformis CCMP3155] 697071164 XM_009652306.1 1629 0 Verticillium dahliae VdLs.17 cobW domain-containing protein partial mRNA -- -- -- -- P94400 648 3.8e-66 Putative metal chaperone YciC OS=Bacillus subtilis (strain 168) GN=yciC PE=2 SV=1 PF02367//PF12833//PF03205//PF01637//PF01443 Threonylcarbamoyl adenosine biosynthesis protein TsaE//Helix-turn-helix domain//Molybdopterin guanine dinucleotide synthesis protein B//Archaeal ATPase//Viral (Superfamily 1) RNA helicase GO:0006355//GO:0002949//GO:0006777 regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification//Mo-molybdopterin cofactor biosynthetic process GO:0043565//GO:0005525//GO:0003700//GO:0005524 sequence-specific DNA binding//GTP binding//transcription factor activity, sequence-specific DNA binding//ATP binding GO:0005667 transcription factor complex KOG2743 Cobalamin synthesis protein Cluster-8309.58996 BP_3 11.00 0.46 1450 470446905 XP_004340009.1 238 2.4e-17 RNA recognition motif domain containing protein [Acanthamoeba castellanii str. Neff]>gi|440796891|gb|ELR17992.1| RNA recognition motif domain containing protein [Acanthamoeba castellanii str. Neff] 768311757 CP010985.1 792 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence K13195 CIRBP cold-inducible RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13195 Q28IQ9 218 2.0e-16 Cold-inducible RNA-binding protein OS=Xenopus tropicalis GN=cirbp PE=2 SV=1 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- -- -- Cluster-8309.58997 BP_3 7.48 0.33 1394 617469795 XP_007574990.1 476 5.8e-45 PREDICTED: gastrula zinc finger protein XlCGF57.1-like [Poecilia formosa] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 454 8.4e-44 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF01426//PF13465//PF00096//PF00320//PF04810//PF02892//PF13912 BAH domain//Zinc-finger double domain//Zinc finger, C2H2 type//GATA zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//C2H2-type zinc finger GO:0006355//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0043565//GO:0003682//GO:0046872//GO:0003700//GO:0003677 zinc ion binding//sequence-specific DNA binding//chromatin binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0030127//GO:0000785//GO:0005667 COPII vesicle coat//chromatin//transcription factor complex -- -- Cluster-8309.58999 BP_3 39.26 0.55 3719 641650582 XP_008189789.1 1137 3.5e-121 PREDICTED: uncharacterized protein LOC103311826 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF03184 helix-turn-helix, Psq domain//DDE superfamily endonuclease -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.5900 BP_3 13.16 0.51 1538 91080735 XP_975438.1 517 1.1e-49 PREDICTED: RING finger protein 121 [Tribolium castaneum]>gi|270005456|gb|EFA01904.1| hypothetical protein TcasGA2_TC007514 [Tribolium castaneum] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q6DD32 360 7.4e-33 RING finger protein 121 OS=Xenopus laevis GN=rnf121 PE=2 SV=1 -- -- -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.59000 BP_3 4.92 0.53 738 478261818 ENN80941.1 513 1.6e-49 hypothetical protein YQE_02646, partial [Dendroctonus ponderosae]>gi|546673709|gb|ERL85268.1| hypothetical protein D910_02689 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VYA8 287 1.0e-24 Transport and Golgi organization protein 2 OS=Drosophila melanogaster GN=Tango2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2342 Uncharacterized conserved protein Cluster-8309.59003 BP_3 8.00 1.35 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59006 BP_3 37.90 0.64 3162 642936917 XP_008194457.1 386 3.6e-34 PREDICTED: uncharacterized protein LOC103313294 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15966//PF00646//PF12937//PF13516 F-box//F-box domain//F-box-like//Leucine Rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.59010 BP_3 11.60 0.58 1251 642928781 XP_008195560.1 696 1.6e-70 PREDICTED: uncharacterized protein LOC654941 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59014 BP_3 77.27 7.31 801 642914271 XP_008201616.1 451 2.6e-42 PREDICTED: sulfiredoxin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12260 SRX1 sulfiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K12260 Q9D975 333 5.2e-30 Sulfiredoxin-1 OS=Mus musculus GN=Srxn1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3388 Predicted transcription regulator/nuclease, contains ParB domain Cluster-8309.59016 BP_3 20.18 0.49 2276 270012708 EFA09156.1 396 1.8e-35 hypothetical protein TcasGA2_TC005493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59021 BP_3 16.95 0.39 2362 189237223 XP_969624.2 1395 2.7e-151 PREDICTED: 45 kDa calcium-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JA6 293 6.7e-25 45 kDa calcium-binding protein OS=Xenopus laevis GN=sdf4 PE=2 SV=1 PF13202//PF00036//PF13833//PF13405//PF13499 EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG4251 Calcium binding protein Cluster-8309.59023 BP_3 1.00 5.54 260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59026 BP_3 13.83 0.62 1373 91084843 XP_966905.1 821 5.6e-85 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 357 1.5e-32 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.59027 BP_3 746.40 42.31 1142 91084843 XP_966905.1 674 5.2e-68 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q922J9 457 3.1e-44 Fatty acyl-CoA reductase 1 OS=Mus musculus GN=Far1 PE=1 SV=1 PF01370//PF01073//PF01118 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process GO:0080019//GO:0000166//GO:0016620//GO:0003824//GO:0050662//GO:0003854//GO:0016616//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//nucleotide binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.59028 BP_3 20.60 1.28 1066 91084843 XP_966905.1 674 4.8e-68 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q922J9 457 2.9e-44 Fatty acyl-CoA reductase 1 OS=Mus musculus GN=Far1 PE=1 SV=1 PF01073//PF01118//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0080019//GO:0000166//GO:0051287//GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//nucleotide binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.59029 BP_3 1073.96 61.53 1133 91084843 XP_966905.1 1042 1.1e-110 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 509 2.9e-50 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.59030 BP_3 35.21 1.88 1194 91084843 XP_966905.1 821 4.9e-85 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 357 1.3e-32 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF10371//PF03015 Domain of unknown function//Male sterility protein GO:0055114 oxidation-reduction process GO:0080019//GO:0016903 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors -- -- -- -- Cluster-8309.59031 BP_3 403.61 4.30 4815 478259731 ENN79575.1 3841 0.0e+00 hypothetical protein YQE_04037, partial [Dendroctonus ponderosae] 688768668 LL362340.1 36 2.12874e-06 Cylicostephanus goldi genome assembly C_goldi_Cheshire ,scaffold CGOC_contig0000203 K02320 POLA1 DNA polymerase alpha subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02320 Q9DE46 2639 1.3e-296 DNA polymerase alpha catalytic subunit OS=Xenopus laevis GN=pola1 PE=1 SV=1 PF01119//PF08996//PF00136//PF03104 DNA mismatch repair protein, C-terminal domain//DNA Polymerase alpha zinc finger//DNA polymerase family B//DNA polymerase family B, exonuclease domain GO:0006260//GO:0006298 DNA replication//mismatch repair GO:0001882//GO:0030983//GO:0008408//GO:0000166//GO:0003887//GO:0003677//GO:0005524 nucleoside binding//mismatched DNA binding//3'-5' exonuclease activity//nucleotide binding//DNA-directed DNA polymerase activity//DNA binding//ATP binding GO:0042575 DNA polymerase complex KOG0970 DNA polymerase alpha, catalytic subunit Cluster-8309.59038 BP_3 169.93 1.40 6126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59043 BP_3 8.04 0.34 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59045 BP_3 44.30 0.51 4490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59046 BP_3 35.30 1.57 1375 270003148 EEZ99595.1 382 4.5e-34 hypothetical protein TcasGA2_TC001582 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59048 BP_3 12.39 0.41 1738 642939164 XP_008200361.1 630 1.0e-62 PREDICTED: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1 [Tribolium castaneum]>gi|270016358|gb|EFA12804.1| hypothetical protein TcasGA2_TC001867 [Tribolium castaneum] -- -- -- -- -- K00736 MGAT2 alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00736 Q921V5 339 2.3e-30 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat2 PE=2 SV=1 PF00273//PF05060 Serum albumin family//N-acetylglucosaminyltransferase II (MGAT2) GO:0009312 oligosaccharide biosynthetic process GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GO:0005795//GO:0016021//GO:0005615 Golgi stack//integral component of membrane//extracellular space KOG2791 N-acetylglucosaminyltransferase Cluster-8309.59049 BP_3 3.00 0.93 446 -- -- -- -- -- 185050396 AP009012.1 53 6.52974e-17 Bombyx mori genomic DNA, chromosome 14, BAC clone:039G04, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5905 BP_3 2.00 0.45 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59054 BP_3 41.90 3.55 861 478251232 ENN71706.1 374 2.4e-33 hypothetical protein YQE_11629, partial [Dendroctonus ponderosae]>gi|546676148|gb|ERL87215.1| hypothetical protein D910_04614 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59056 BP_3 39.48 1.29 1772 270015676 EFA12124.1 560 1.3e-54 hypothetical protein TcasGA2_TC002270 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.59064 BP_3 70.66 4.75 1008 91082525 XP_973459.1 284 7.6e-23 PREDICTED: circadian clock-controlled protein [Tribolium castaneum]>gi|270007126|gb|EFA03574.1| hypothetical protein TcasGA2_TC013657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00520//PF04277 Ion transport protein//Oxaloacetate decarboxylase, gamma chain GO:0006814//GO:0006090//GO:0071436//GO:0006811//GO:0006525//GO:0055085//GO:0006560 sodium ion transport//pyruvate metabolic process//sodium ion export//ion transport//arginine metabolic process//transmembrane transport//proline metabolic process GO:0005216//GO:0015081//GO:0008948 ion channel activity//sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.59066 BP_3 4.00 0.33 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59070 BP_3 24.00 0.40 3167 270009944 EFA06392.1 683 1.3e-68 hypothetical protein TcasGA2_TC009270 [Tribolium castaneum] 642927517 XM_008197079.1 196 1.58839e-95 PREDICTED: Tribolium castaneum uncharacterized LOC659254 (LOC659254), transcript variant X1, mRNA K07847 REM1 Rad and Gem related GTP binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07847 O35929 246 2.5e-19 GTP-binding protein REM 1 OS=Mus musculus GN=Rem1 PE=1 SV=1 PF00071//PF00025 Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- -- -- Cluster-8309.59072 BP_3 12.88 0.37 1977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59074 BP_3 3.00 0.60 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59075 BP_3 165.00 4.60 2019 213623544 AAI69887.1 700 8.9e-71 Frizzled 10A [Xenopus laevis]>gi|213625125|gb|AAI69883.1| Frizzled 10A [Xenopus laevis] -- -- -- -- -- -- -- -- -- Q9DEB5 700 3.6e-72 Frizzled-10-A OS=Xenopus laevis GN=fzd10-a PE=2 SV=1 PF01534//PF01392 Frizzled/Smoothened family membrane region//Fz domain GO:0007166 cell surface receptor signaling pathway GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.59076 BP_3 81.00 2.36 1945 -- -- -- -- -- 768311753 CP010981.1 1932 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF00651//PF09401//PF00906 BTB/POZ domain//RNA synthesis protein NSP10//Hepatitis core antigen GO:0019079//GO:0009405 viral genome replication//pathogenesis GO:0003723//GO:0008270//GO:0005515//GO:0005198 RNA binding//zinc ion binding//protein binding//structural molecule activity -- -- -- -- Cluster-8309.59078 BP_3 3.00 9.10 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59080 BP_3 117.00 10.21 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59084 BP_3 3.00 0.74 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59085 BP_3 31.76 1.09 1700 558186421 XP_006102446.1 472 2.0e-44 PREDICTED: zinc finger protein 850-like, partial [Myotis lucifugus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51814 449 3.9e-43 Zinc finger protein 41 OS=Homo sapiens GN=ZNF41 PE=1 SV=2 PF16622//PF00412//PF04810//PF13912//PF07975//PF13465//PF00628//PF00096 zinc-finger C2H2-type//LIM domain//Sec23/Sec24 zinc finger//C2H2-type zinc finger//TFIIH C1-like domain//Zinc-finger double domain//PHD-finger//Zinc finger, C2H2 type GO:0006281//GO:0006886//GO:0006888 DNA repair//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.59086 BP_3 34.92 5.48 599 642937753 XP_008198932.1 221 9.2e-16 PREDICTED: zinc finger protein 480-like [Tribolium castaneum]>gi|270000769|gb|EEZ97216.1| hypothetical protein TcasGA2_TC011009 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF13912//PF07776//PF00096//PF13465 PHD-finger//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.59088 BP_3 94.92 1.77 2873 675378821 KFM71723.1 674 1.3e-67 Zinc finger protein 271, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5RDX1 645 1.2e-65 Zinc finger protein 585A OS=Pongo abelii GN=ZNF585A PE=2 SV=1 PF13465//PF00096//PF07975//PF00412//PF04810//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain//LIM domain//Sec23/Sec24 zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006886//GO:0006281//GO:0006888 intracellular protein transport//DNA repair//ER to Golgi vesicle-mediated transport GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.59091 BP_3 9.79 0.40 1471 478250898 ENN71384.1 250 9.8e-19 hypothetical protein YQE_11931, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N302 126 9.6e-06 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.59092 BP_3 26.85 0.69 2162 645016819 XP_008211643.1 572 6.6e-56 PREDICTED: angiogenic factor with G patch and FHA domains 1 isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q8N302 132 2.9e-06 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF07851//PF00498 TMPIT-like protein//FHA domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.59096 BP_3 41.36 0.39 5460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59097 BP_3 6.00 0.43 960 91085559 XP_966910.1 977 3.2e-103 PREDICTED: cyclin-dependent kinase 20 [Tribolium castaneum]>gi|270010065|gb|EFA06513.1| hypothetical protein TcasGA2_TC009414 [Tribolium castaneum] -- -- -- -- -- K08817 CCRK cell cycle related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08817 A8WIP6 796 1.3e-83 Cyclin-dependent kinase 20 OS=Danio rerio GN=cdk20 PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0000166//GO:0016773//GO:0004672 ATP binding//nucleotide binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7 Cluster-8309.59098 BP_3 243.00 19.07 906 642924550 XP_008194340.1 480 1.3e-45 PREDICTED: endocuticle structural glycoprotein SgAbd-8 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 317 4.2e-28 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.59099 BP_3 3.00 0.50 581 642926548 XP_008194917.1 135 8.3e-06 PREDICTED: uncharacterized protein LOC103313437 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5910 BP_3 10.00 0.36 1640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59103 BP_3 78.17 3.99 1235 391226631 AFM38203.1 701 4.2e-71 Rieske Fe-S protein 1 [Anasa tristis] -- -- -- -- -- K00411 UQCRFS1, RIP1, petA ubiquinol-cytochrome c reductase iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00411 Q69BJ7 657 2.2e-67 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Saimiri sciureus GN=UQCRFS1 PE=3 SV=1 PF03332//PF02921//PF00355 Eukaryotic phosphomannomutase//Ubiquinol cytochrome reductase transmembrane region//Rieske [2Fe-2S] domain GO:0009298//GO:0006119//GO:0006118//GO:0015992//GO:0006013//GO:0055114//GO:0006000 GDP-mannose biosynthetic process//oxidative phosphorylation//obsolete electron transport//proton transport//mannose metabolic process//oxidation-reduction process//fructose metabolic process GO:0051537//GO:0004615//GO:0008121//GO:0016491 2 iron, 2 sulfur cluster binding//phosphomannomutase activity//ubiquinol-cytochrome-c reductase activity//oxidoreductase activity GO:0005737 cytoplasm KOG1671 Ubiquinol cytochrome c reductase, subunit RIP1 Cluster-8309.59105 BP_3 9.00 0.41 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59106 BP_3 21.00 0.75 1645 556773000 XP_005981661.1 770 5.5e-79 PREDICTED: O-acetylhomoserine (thiol)-lyase-like [Pantholops hodgsonii] 697080648 XM_009655599.1 1448 0 Verticillium dahliae VdLs.17 O-acetylhomoserine (thiol)-lyase partial mRNA -- -- -- -- P50125 966 4.2e-103 O-acetylhomoserine (thiol)-lyase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) GN=cysD PE=2 SV=2 PF00155//PF01212//PF10723//PF02347//PF01053//PF00107 Aminotransferase class I and II//Beta-eliminating lyase//Replication regulatory protein RepB//Glycine cleavage system P-protein//Cys/Met metabolism PLP-dependent enzyme//Zinc-binding dehydrogenase GO:0006520//GO:0009058//GO:0055114//GO:0006544//GO:0006546//GO:0006566//GO:0006563//GO:0006276 cellular amino acid metabolic process//biosynthetic process//oxidation-reduction process//glycine metabolic process//glycine catabolic process//threonine metabolic process//L-serine metabolic process//plasmid maintenance GO:0016829//GO:0004375//GO:0030170 lyase activity//glycine dehydrogenase (decarboxylating) activity//pyridoxal phosphate binding -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.59108 BP_3 116.79 1.81 3402 270011110 EFA07558.1 487 7.5e-46 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 351 1.8e-31 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59109 BP_3 130.48 4.76 1613 270011110 EFA07558.1 571 6.4e-56 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 433 2.7e-41 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59115 BP_3 23.87 0.34 3718 270011110 EFA07558.1 487 8.2e-46 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 351 2.0e-31 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59119 BP_3 33.78 1.71 1242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59122 BP_3 5.00 0.47 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59130 BP_3 6.29 0.51 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02294 7kD DNA-binding domain GO:0051252 regulation of RNA metabolic process GO:0004521//GO:0003677 endoribonuclease activity//DNA binding -- -- -- -- Cluster-8309.59131 BP_3 2028.46 36.61 2962 91093748 XP_969297.1 2060 2.6e-228 PREDICTED: cerebellar degeneration-related protein 2-like isoform X1 [Tribolium castaneum]>gi|270013015|gb|EFA09463.1| hypothetical protein TcasGA2_TC010679 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 334 1.5e-29 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.59136 BP_3 909.09 5.92 7696 170286895 BAG13449.1 5321 0.0e+00 chitinase [Monochamus alternatus] 170286894 AB428670.1 3359 0 Monochamus alternatus MaChiPm2 mRNA for chitinase, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W5U2 1545 1.4e-169 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF00704//PF01607//PF03970 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain//Herpesvirus UL37 tegument protein GO:0005975//GO:0019068//GO:0006030 carbohydrate metabolic process//virion assembly//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region -- -- Cluster-8309.59137 BP_3 19.46 0.99 1243 795020235 XP_011859854.1 1176 3.5e-126 PREDICTED: putative uncharacterized protein FLJ37770 [Vollenhovia emeryi] 795113965 XM_012027458.1 217 1.2991e-107 PREDICTED: Vollenhovia emeryi odorant receptor 59a-like (LOC105570334), transcript variant X2, mRNA -- -- -- -- Q7JQ07 395 5.2e-37 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF09339//PF00665 IclR helix-turn-helix domain//Integrase core domain GO:0015074//GO:0006355 DNA integration//regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.5914 BP_3 39.58 1.03 2151 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59140 BP_3 2017.37 18.34 5593 642917556 XP_008191255.1 3201 0.0e+00 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.86012e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 257 2.4e-20 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.59151 BP_3 9.00 0.68 934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59152 BP_3 675.32 16.45 2270 270002502 EEZ98949.1 1257 2.6e-135 hypothetical protein TcasGA2_TC004573 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 716 5.7e-74 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.59155 BP_3 2.00 0.31 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59158 BP_3 170.93 1.10 7776 642924895 XP_008194087.1 2497 1.4e-278 PREDICTED: laminin subunit alpha-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P24043 1163 2.9e-125 Laminin subunit alpha-2 OS=Homo sapiens GN=LAMA2 PE=1 SV=4 PF00424//PF04144//PF06009//PF08329//PF07544//PF00722 REV protein (anti-repression trans-activator protein)//SCAMP family//Laminin Domain II//Chitinase A, N-terminal domain//RNA polymerase II transcription mediator complex subunit 9//Glycosyl hydrolases family 16 GO:0016998//GO:0005975//GO:0015031//GO:0006032//GO:0006357//GO:0006355//GO:0007155 cell wall macromolecule catabolic process//carbohydrate metabolic process//protein transport//chitin catabolic process//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//cell adhesion GO:0001104//GO:0004553//GO:0004568//GO:0003700 RNA polymerase II transcription cofactor activity//hydrolase activity, hydrolyzing O-glycosyl compounds//chitinase activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0042025//GO:0016021//GO:0016592 transcription factor complex//host cell nucleus//integral component of membrane//mediator complex KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.59160 BP_3 121.73 0.80 7607 642924895 XP_008194087.1 1934 2.7e-213 PREDICTED: laminin subunit alpha-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P24043 1137 2.9e-122 Laminin subunit alpha-2 OS=Homo sapiens GN=LAMA2 PE=1 SV=4 PF00806//PF00706//PF08329//PF07544//PF06009//PF05225//PF00424 Pumilio-family RNA binding repeat//Anenome neurotoxin//Chitinase A, N-terminal domain//RNA polymerase II transcription mediator complex subunit 9//Laminin Domain II//helix-turn-helix, Psq domain//REV protein (anti-repression trans-activator protein) GO:0016998//GO:0009966//GO:0006032//GO:0006355//GO:0007155//GO:0006357 cell wall macromolecule catabolic process//regulation of signal transduction//chitin catabolic process//regulation of transcription, DNA-templated//cell adhesion//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0003677//GO:0003723//GO:0003700//GO:0004568 RNA polymerase II transcription cofactor activity//DNA binding//RNA binding//transcription factor activity, sequence-specific DNA binding//chitinase activity GO:0005667//GO:0042025//GO:0016592//GO:0005576 transcription factor complex//host cell nucleus//mediator complex//extracellular region KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.59161 BP_3 17.51 0.52 1909 642934625 XP_972040.2 448 1.4e-41 PREDICTED: atrial natriuretic peptide-converting enzyme isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59173 BP_3 207.43 2.43 4408 270009035 EFA05483.1 2466 3.2e-275 hypothetical protein TcasGA2_TC015667 [Tribolium castaneum] 642926285 XM_008196640.1 273 3.4825e-138 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1584 2.5e-174 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF13895//PF00069//PF01392//PF07714 Immunoglobulin domain//Protein kinase domain//Fz domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.59178 BP_3 30.95 0.51 3240 642926332 XP_968832.2 2767 3.0e-310 PREDICTED: RING finger protein 207 isoform X2 [Tribolium castaneum] 642926333 XM_008196659.1 246 2.60688e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 580 4.8e-58 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF04728//PF04513//PF06005//PF01667//PF04673 Lipoprotein leucine-zipper//Baculovirus polyhedron envelope protein, PEP, C terminus//Protein of unknown function (DUF904)//Ribosomal protein S27//Polyketide synthesis cyclase GO:0000917//GO:0043093//GO:0042254//GO:0006412//GO:0030639 barrier septum assembly//FtsZ-dependent cytokinesis//ribosome biogenesis//translation//polyketide biosynthetic process GO:0003735//GO:0005198 structural constituent of ribosome//structural molecule activity GO:0005737//GO:0005622//GO:0005840//GO:0019031//GO:0019867//GO:0019028 cytoplasm//intracellular//ribosome//viral envelope//outer membrane//viral capsid -- -- Cluster-8309.59180 BP_3 135.54 2.30 3138 642931541 XP_008196629.1 2805 0.0e+00 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 Q76MJ5 1249 1.2e-135 Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Homo sapiens GN=ERN2 PE=1 SV=4 PF00069//PF06293//PF07714//PF06479//PF00804 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Ribonuclease 2-5A//Syntaxin GO:0044238//GO:0051252//GO:0006468//GO:0006397//GO:0044260 primary metabolic process//regulation of RNA metabolic process//protein phosphorylation//mRNA processing//cellular macromolecule metabolic process GO:0004672//GO:0016773//GO:0004540//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ribonuclease activity//ATP binding GO:0016020 membrane KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.59181 BP_3 57.88 2.40 1455 642931541 XP_008196629.1 1175 5.3e-126 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 Q09499 573 1.4e-57 Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=1 SV=2 -- -- GO:0051252//GO:0016310//GO:0009069//GO:0006468//GO:0006397 regulation of RNA metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//mRNA processing GO:0004674//GO:0016891//GO:0005524 protein serine/threonine kinase activity//endoribonuclease activity, producing 5'-phosphomonoesters//ATP binding -- -- KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.59182 BP_3 193.85 2.75 3691 478256893 ENN77062.1 359 5.6e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 5.7e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF01844//PF16622//PF02150//PF07975//PF00096//PF13465 HNH endonuclease//zinc-finger C2H2-type//RNA polymerases M/15 Kd subunit//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006281//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//DNA repair//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003676//GO:0008270//GO:0003677//GO:0003899//GO:0004519 metal ion binding//nucleic acid binding//zinc ion binding//DNA binding//DNA-directed RNA polymerase activity//endonuclease activity GO:0005730 nucleolus -- -- Cluster-8309.59183 BP_3 4.00 0.38 805 478268914 ENN83264.1 388 5.3e-35 hypothetical protein YQE_00377, partial [Dendroctonus ponderosae]>gi|478269813|gb|ENN83404.1| hypothetical protein YQE_00237, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7M4F3 307 5.4e-27 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.59186 BP_3 8.72 1.06 689 642927136 XP_972282.2 565 1.4e-55 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6YYZ1 158 8.8e-10 Lysine-specific histone demethylase 1 homolog 2 OS=Oryza sativa subsp. japonica GN=Os08g0143400 PE=2 SV=1 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.59190 BP_3 14.22 3.07 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59191 BP_3 18.78 3.18 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59192 BP_3 1.00 0.80 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59196 BP_3 18.74 6.74 425 332376915 AEE63597.1 285 2.5e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02956 RP-S15, MRPS15, rpsO small subunit ribosomal protein S15 http://www.genome.jp/dbget-bin/www_bget?ko:K02956 Q8WTC1 224 1.2e-17 28S ribosomal protein S15, mitochondrial OS=Drosophila melanogaster GN=bonsai PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59202 BP_3 46.61 2.88 1071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.59204 BP_3 747.40 17.78 2318 642938915 XP_008195579.1 1677 5.2e-184 PREDICTED: suppressor APC domain-containing protein 2 [Tribolium castaneum]>gi|270016161|gb|EFA12609.1| hypothetical protein TcasGA2_TC006850 [Tribolium castaneum] 642938914 XM_008197357.1 121 5.70411e-54 PREDICTED: Tribolium castaneum suppressor APC domain-containing protein 2 (LOC660078), mRNA -- -- -- -- Q9D818 258 7.5e-21 Suppressor APC domain-containing protein 2 OS=Mus musculus GN=Sapcd2 PE=2 SV=1 PF13405//PF04111 EF-hand domain//Autophagy protein Apg6 GO:0006914 autophagy GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.59206 BP_3 1.00 1.01 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5921 BP_3 7.00 0.34 1291 307212038 EFN87922.1 138 8.3e-06 hypothetical protein EAI_08475, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59212 BP_3 1.00 1.32 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5922 BP_3 12.00 0.56 1321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59222 BP_3 27.06 0.76 2016 546676898 ERL87822.1 924 9.4e-97 hypothetical protein D910_05211 [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q52KD1 575 1.1e-57 Sodium/bile acid cotransporter 7-B OS=Xenopus laevis GN=slc10a7-b PE=2 SV=1 PF05972 APC 15 residue motif GO:0016055 Wnt signaling pathway GO:0008013 beta-catenin binding GO:0016342 catenin complex -- -- Cluster-8309.59231 BP_3 50.46 0.43 5938 91079028 XP_974924.1 1752 2.7e-192 PREDICTED: glutamate-rich WD repeat-containing protein 1 [Tribolium castaneum]>gi|270004178|gb|EFA00626.1| hypothetical protein TcasGA2_TC003502 [Tribolium castaneum] 687865299 LK927543.1 35 9.45542e-06 Caenorhabditis elegans genome assembly C_elegans_Bristol_N2_v1_5_4 ,scaffold CELN2_scaffold0000013 K14848 RRB1, GRWD1 ribosome assembly protein RRB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14848 Q9BQ67 1160 4.9e-125 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens GN=GRWD1 PE=1 SV=1 PF00400//PF01119//PF09514//PF08676 WD domain, G-beta repeat//DNA mismatch repair protein, C-terminal domain//SSXRD motif//MutL C terminal dimerisation domain GO:0006355//GO:0006298 regulation of transcription, DNA-templated//mismatch repair GO:0030983//GO:0005524//GO:0005515 mismatched DNA binding//ATP binding//protein binding GO:0005634 nucleus KOG0302 Ribosome Assembly protein Cluster-8309.59233 BP_3 16.48 0.45 2055 642919805 XP_008192075.1 807 3.5e-83 PREDICTED: nuclear transcription factor Y subunit alpha isoform X2 [Tribolium castaneum] 642919804 XM_008193853.1 68 1.4641e-24 PREDICTED: Tribolium castaneum nuclear transcription factor Y subunit alpha (LOC661458), transcript variant X2, mRNA K08064 NFYA nuclear transcription factor Y, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08064 P23511 365 2.6e-33 Nuclear transcription factor Y subunit alpha OS=Homo sapiens GN=NFYA PE=1 SV=2 PF00737//PF11525//PF02045 Photosystem II 10 kDa phosphoprotein//Copper resistance protein K//CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B GO:0006355//GO:0015979//GO:0050821 regulation of transcription, DNA-templated//photosynthesis//protein stabilization GO:0046872//GO:0003700//GO:0042301 metal ion binding//transcription factor activity, sequence-specific DNA binding//phosphate ion binding GO:0009523//GO:0016020//GO:0005667 photosystem II//membrane//transcription factor complex KOG1561 CCAAT-binding factor, subunit B (HAP2) Cluster-8309.59235 BP_3 315.02 8.08 2172 546684923 ERL94505.1 1330 8.5e-144 hypothetical protein D910_11782 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q29J90 590 2.2e-59 G-protein coupled receptor moody OS=Drosophila pseudoobscura pseudoobscura GN=moody PE=3 SV=2 PF02364//PF00001//PF13903 1,3-beta-glucan synthase component//7 transmembrane receptor (rhodopsin family)//PMP-22/EMP/MP20/Claudin tight junction GO:0005982//GO:0005985//GO:0006075//GO:0007186 starch metabolic process//sucrose metabolic process//(1->3)-beta-D-glucan biosynthetic process//G-protein coupled receptor signaling pathway GO:0003843//GO:0004930 1,3-beta-D-glucan synthase activity//G-protein coupled receptor activity GO:0016021//GO:0000148//GO:0016020 integral component of membrane//1,3-beta-D-glucan synthase complex//membrane -- -- Cluster-8309.59238 BP_3 32.08 1.09 1714 546680075 ERL90427.1 374 4.8e-33 hypothetical protein D910_07776 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26005 167 2.0e-10 Ring-infected erythrocyte surface antigen (Fragment) OS=Plasmodium falciparum (isolate Palo Alto / Uganda) GN=RESA PE=3 SV=1 PF08061 P68HR (NUC004) repeat -- -- GO:0016818//GO:0003724//GO:0003712 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//RNA helicase activity//transcription cofactor activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.59239 BP_3 9.00 0.34 1574 607360775 EZA55096.1 465 1.2e-43 hypothetical protein X777_05351, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59241 BP_3 65.00 3.56 1171 578468793 AFR78280.2 1757 1.4e-193 immunoglobulin heavy chain, partial [Homo sapiens] 38382880 BC062336.1 1145 0 Homo sapiens immunoglobulin heavy constant gamma 1 (G1m marker), mRNA (cDNA clone IMAGE:6300554) K06856 IGH immunoglobulin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K06856 P01857 1672 4.1e-185 Ig gamma-1 chain C region OS=Homo sapiens GN=IGHG1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59247 BP_3 47.80 0.81 3145 15450324 AAK96031.1 912 3.6e-95 homeodomain transcription factor Prothoraxless [Tribolium castaneum]>gi|270002803|gb|EEZ99250.1| antennapedia [Tribolium castaneum] 86515363 NM_001039416.1 265 6.93437e-134 Tribolium castaneum prothoraxless (Ptl), mRNA >gnl|BL_ORD_ID|908858 Tribolium castaneum prothoraxless mRNA, complete cds K09307 HOX_7 homeobox protein HoxA/B7 http://www.genome.jp/dbget-bin/www_bget?ko:K09307 P02833 379 9.5e-35 Homeotic protein antennapedia OS=Drosophila melanogaster GN=Antp PE=1 SV=1 PF03153//PF00046 Transcription factor IIA, alpha/beta subunit//Homeobox domain GO:0006367 transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.59249 BP_3 27.11 0.46 3139 642939345 XP_008197083.1 1479 6.5e-161 PREDICTED: uncharacterized protein LOC103314054 [Tribolium castaneum] -- -- -- -- -- K09453 SNAPC4 snRNA-activating protein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09453 Q5SXM2 383 3.3e-35 snRNA-activating protein complex subunit 4 OS=Homo sapiens GN=SNAPC4 PE=1 SV=1 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0003676//GO:0005524//GO:0016818 nucleic acid binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0049 Transcription factor, Myb superfamily Cluster-8309.59250 BP_3 154.03 1.46 5388 91085393 XP_966738.1 3860 0.0e+00 PREDICTED: Hermansky-Pudlak syndrome 3 protein homolog [Tribolium castaneum]>gi|270008408|gb|EFA04856.1| hypothetical protein TcasGA2_TC014910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q969F9 337 1.2e-29 Hermansky-Pudlak syndrome 3 protein OS=Homo sapiens GN=HPS3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59252 BP_3 89.15 0.84 5418 91085393 XP_966738.1 3854 0.0e+00 PREDICTED: Hermansky-Pudlak syndrome 3 protein homolog [Tribolium castaneum]>gi|270008408|gb|EFA04856.1| hypothetical protein TcasGA2_TC014910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q969F9 337 1.2e-29 Hermansky-Pudlak syndrome 3 protein OS=Homo sapiens GN=HPS3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59255 BP_3 27.64 0.56 2658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59257 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59259 BP_3 5.00 0.52 751 -- -- -- -- -- 768311752 CP010980.1 742 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59260 BP_3 2.00 0.51 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59261 BP_3 279.01 7.84 2006 546678907 ERL89445.1 1731 2.5e-190 hypothetical protein D910_06812 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 953 1.7e-101 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01073//PF00106//PF01118//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 metabolic process//estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0051287//GO:0016491//GO:0003824//GO:0050662//GO:0003854//GO:0016620//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.59269 BP_3 190.96 8.26 1406 91093719 XP_967705.1 374 3.9e-33 PREDICTED: probable small nuclear ribonucleoprotein G [Tribolium castaneum]>gi|270012988|gb|EFA09436.1| hypothetical protein TcasGA2_TC010648 [Tribolium castaneum] -- -- -- -- -- K11099 SNRPG, SMG small nuclear ribonucleoprotein G http://www.genome.jp/dbget-bin/www_bget?ko:K11099 Q9VXE0 329 2.7e-29 Probable small nuclear ribonucleoprotein G OS=Drosophila melanogaster GN=SmG PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1780 Small Nuclear ribonucleoprotein G Cluster-8309.59270 BP_3 32.34 1.88 1123 478249917 ENN70424.1 1427 2.5e-155 hypothetical protein YQE_12929, partial [Dendroctonus ponderosae] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P39087 861 4.4e-91 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.59271 BP_3 5.91 0.66 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59272 BP_3 22.64 0.51 2413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59273 BP_3 63.69 2.77 1401 478249917 ENN70424.1 1418 3.4e-154 hypothetical protein YQE_12929, partial [Dendroctonus ponderosae] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P39087 861 5.4e-91 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.59274 BP_3 6.65 0.45 1002 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59275 BP_3 3.00 0.97 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59276 BP_3 26.36 0.59 2460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59277 BP_3 1613.24 11.05 7329 270007892 EFA04340.1 5527 0.0e+00 hypothetical protein TcasGA2_TC014634 [Tribolium castaneum] 627401361 KF147149.1 1073 0 Anthonomus grandis chitin synthase I (CHS1) mRNA, complete cds K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q4P9K9 230 4.2e-17 Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=CHS8 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2571 Chitin synthase/hyaluronan synthase (glycosyltransferases) Cluster-8309.59281 BP_3 241.32 4.36 2962 270001558 EEZ98005.1 1757 3.5e-193 hypothetical protein TcasGA2_TC000404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1G0 226 4.9e-17 Zinc finger protein 687 OS=Homo sapiens GN=ZNF687 PE=1 SV=1 PF00096//PF13465//PF16622//PF13912//PF09520 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger//Type II restriction endonuclease, TdeIII GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0009036//GO:0003677//GO:0046872 Type II site-specific deoxyribonuclease activity//DNA binding//metal ion binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.59282 BP_3 60.93 0.36 8410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59292 BP_3 22.00 0.72 1760 478257786 ENN77929.1 870 1.5e-90 hypothetical protein YQE_05606, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4MYA4 539 1.5e-53 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083//PF03861//PF02295 Major Facilitator Superfamily//Sugar (and other) transporter//ANTAR domain//Adenosine deaminase z-alpha domain GO:0055085//GO:0006807 transmembrane transport//nitrogen compound metabolic process GO:0003723//GO:0022857//GO:0003726 RNA binding//transmembrane transporter activity//double-stranded RNA adenosine deaminase activity GO:0016021 integral component of membrane -- -- Cluster-8309.59294 BP_3 35.00 0.81 2370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00830 Ribosomal L28 family GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.59297 BP_3 85.20 4.17 1276 642915964 XP_008190829.1 983 8.6e-104 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 316 7.8e-28 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59307 BP_3 23.05 0.81 1660 642918264 XP_008191437.1 623 6.2e-62 PREDICTED: dual oxidase isoform X1 [Tribolium castaneum]>gi|270004810|gb|EFA01258.1| hypothetical protein TcasGA2_TC002498 [Tribolium castaneum] -- -- -- -- -- K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 526 4.5e-52 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 -- -- GO:0006979//GO:0055114//GO:0006804 response to oxidative stress//oxidation-reduction process//obsolete peroxidase reaction GO:0020037//GO:0004601//GO:0005509 heme binding//peroxidase activity//calcium ion binding GO:0016021 integral component of membrane KOG2408 Peroxidase/oxygenase Cluster-8309.5931 BP_3 4.00 0.80 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59310 BP_3 15.00 0.99 1025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59312 BP_3 6.00 0.35 1128 -- -- -- -- -- 76560264 DQ085591.1 73 1.31792e-27 Colletes halophilus voucher NHM AD9 5.8S ribosomal RNA gene and internal transcribed spacer 2, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59314 BP_3 8559.00 210.13 2255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.59316 BP_3 44.00 1.32 1899 270015440 EFA11888.1 246 3.7e-18 hypothetical protein TcasGA2_TC016001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59317 BP_3 7.00 1.81 478 270015440 EFA11888.1 327 3.7e-28 hypothetical protein TcasGA2_TC016001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K259 203 3.7e-15 Gypsy retrotransposon integrase-like protein 1 OS=Mus musculus GN=Gin1 PE=2 SV=2 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.59318 BP_3 49.19 0.75 3433 270016078 EFA12526.1 1401 7.8e-152 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 718 5.1e-74 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.59319 BP_3 2.93 0.32 734 642933293 XP_968154.2 342 1.0e-29 PREDICTED: putative ribosomal RNA methyltransferase CG11447 [Tribolium castaneum] -- -- -- -- -- K02427 rlmE, rrmJ, ftsJ 23S rRNA (uridine2552-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K02427 Q9VDT6 314 7.6e-28 rRNA methyltransferase 2, mitochondrial OS=Drosophila melanogaster GN=CG11447 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG4589 Cell division protein FtsJ Cluster-8309.59320 BP_3 5.00 0.52 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59321 BP_3 7.00 1.80 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59325 BP_3 95.54 2.18 2407 642910984 XP_008193495.1 971 4.0e-102 PREDICTED: uncharacterized protein LOC662081 isoform X2 [Tribolium castaneum] 389615417 AK405336.1 104 1.67126e-44 Papilio polytes mRNA, conserved hypothetical protein, sequence id: Pp-0941, expressed in epidermis -- -- -- -- -- -- -- -- PF15221//PF01607 Lens epithelial cell protein LEP503//Chitin binding Peritrophin-A domain GO:0006030//GO:0007275 chitin metabolic process//multicellular organismal development GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.59330 BP_3 14.56 1.00 993 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59332 BP_3 205.04 4.49 2495 91079362 XP_970302.1 1401 5.7e-152 PREDICTED: islet cell autoantigen 1 [Tribolium castaneum]>gi|270003491|gb|EEZ99938.1| hypothetical protein TcasGA2_TC002734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63054 650 2.8e-66 Islet cell autoantigen 1 OS=Rattus norvegicus GN=Ica1 PE=2 SV=2 PF06456 Arfaptin-like domain -- -- GO:0019904 protein domain specific binding -- -- KOG3891 Secretory vesicle-associated protein ICA69, contains Arfaptin domain Cluster-8309.59335 BP_3 154.27 0.64 11882 270002715 EEZ99162.1 7120 0.0e+00 hypothetical protein TcasGA2_TC016161 [Tribolium castaneum] -- -- -- -- -- K06642 PRKDC DNA-dependent protein kinase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06642 Q9DEI1 1179 6.2e-127 DNA-dependent protein kinase catalytic subunit OS=Xenopus laevis GN=prkdc PE=2 SV=1 PF08030//PF02260//PF08163//PF00454 Ferric reductase NAD binding domain//FATC domain//NUC194 domain//Phosphatidylinositol 3- and 4-kinase GO:0055114//GO:0016310//GO:0006303//GO:0009069 oxidation-reduction process//phosphorylation//double-strand break repair via nonhomologous end joining//serine family amino acid metabolic process GO:0016773//GO:0005515//GO:0016491//GO:0003677//GO:0005524//GO:0004677 phosphotransferase activity, alcohol group as acceptor//protein binding//oxidoreductase activity//DNA binding//ATP binding//DNA-dependent protein kinase activity GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0891 DNA-dependent protein kinase Cluster-8309.59336 BP_3 15.43 0.40 2134 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03521 Kv2 voltage-gated K+ channel GO:0006813 potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0008076 voltage-gated potassium channel complex -- -- Cluster-8309.59340 BP_3 146.76 3.11 2568 189237665 XP_001812360.1 664 1.7e-66 PREDICTED: RNA-binding protein 34 [Tribolium castaneum]>gi|270007816|gb|EFA04264.1| hypothetical protein TcasGA2_TC014554 [Tribolium castaneum] -- -- -- -- -- K14837 NOP12 nucleolar protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14837 P42696 339 3.4e-30 RNA-binding protein 34 OS=Homo sapiens GN=RBM34 PE=1 SV=2 PF04258//PF16367//PF00076 Signal peptide peptidase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG0118 FOG: RRM domain Cluster-8309.59342 BP_3 59.00 1.37 2368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59346 BP_3 13.00 1.40 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59347 BP_3 24.00 1.20 1255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59348 BP_3 18.84 0.43 2389 546676181 ERL87248.1 1328 1.6e-143 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O30408 220 2.0e-16 Tyrocidine synthase 2 OS=Brevibacillus parabrevis GN=tycB PE=3 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.59351 BP_3 201.50 3.96 2744 91084285 XP_971581.1 904 2.7e-94 PREDICTED: uncharacterized protein LOC660239 isoform X2 [Tribolium castaneum]>gi|270008748|gb|EFA05196.1| hypothetical protein TcasGA2_TC015330 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00688 TGF-beta propeptide GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.59352 BP_3 84.01 1.64 2761 642925259 XP_008194483.1 710 8.4e-72 PREDICTED: uncharacterized protein LOC660239 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00688 TGF-beta propeptide GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.59355 BP_3 2.00 0.66 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59356 BP_3 2.00 0.39 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59360 BP_3 2.00 0.83 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59378 BP_3 17.51 0.58 1736 795117684 XP_011883383.1 198 1.2e-12 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Vollenhovia emeryi] -- -- -- -- -- K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 146 5.5e-08 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.5938 BP_3 2.00 0.41 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59381 BP_3 16.12 0.57 1657 270004805 EFA01253.1 1832 4.0e-202 hypothetical protein TcasGA2_TC002449 [Tribolium castaneum] -- -- -- -- -- K04984 TRPA1, ANKTM1 transient receptor potential cation channel subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04984 Q7Z020 1400 2.0e-153 Transient receptor potential cation channel subfamily A member 1 OS=Drosophila melanogaster GN=TrpA1 PE=2 SV=4 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.59390 BP_3 1.00 0.32 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59391 BP_3 74.00 2.25 1876 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59394 BP_3 1.00 3.93 271 676451318 XP_009052666.1 141 7.8e-07 hypothetical protein LOTGIDRAFT_71630, partial [Lottia gigantea]>gi|556107994|gb|ESO96646.1| hypothetical protein LOTGIDRAFT_71630, partial [Lottia gigantea] 462334797 APGK01038457.1 85 6.12098e-35 Dendroctonus ponderosae Seq01038467, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59396 BP_3 44.62 1.86 1450 542171132 XP_003442380.2 374 4.0e-33 PREDICTED: tyrosine-protein kinase Fes/Fps-like isoform X1 [Oreochromis niloticus] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 Q8CBF3 329 2.7e-29 Ephrin type-B receptor 1 OS=Mus musculus GN=Ephb1 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.59397 BP_3 26.26 1.20 1344 332373512 AEE61897.1 1085 1.3e-115 unknown [Dendroctonus ponderosae]>gi|478261742|gb|ENN80889.1| hypothetical protein YQE_02678, partial [Dendroctonus ponderosae]>gi|546674326|gb|ERL85730.1| hypothetical protein D910_03145 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 Q9VKH6 856 2.0e-90 Lysosomal thioesterase PPT2 homolog OS=Drosophila melanogaster GN=Ppt2 PE=2 SV=1 PF02089 Palmitoyl protein thioesterase -- -- GO:0098599 palmitoyl hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.59406 BP_3 24.38 2.94 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59409 BP_3 23.00 3.24 634 553041307 AGY54953.1 193 1.7e-12 encapsulation-relating protein [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59412 BP_3 187.67 1.81 5301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59413 BP_3 271.33 2.58 5359 154416763 XP_001581403.1 156 2.8e-07 viral A-type inclusion protein [Trichomonas vaginalis G3]>gi|121915630|gb|EAY20417.1| viral A-type inclusion protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59415 BP_3 4.00 0.31 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59418 BP_3 141.00 1.58 4600 642916983 XP_008199582.1 2574 1.0e-287 PREDICTED: DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10742 DNA2 DNA replication ATP-dependent helicase Dna2 http://www.genome.jp/dbget-bin/www_bget?ko:K10742 E1BMP7 1405 1.5e-153 DNA replication ATP-dependent helicase/nuclease DNA2 OS=Bos taurus GN=DNA2 PE=3 SV=3 PF02562//PF01443//PF02606 PhoH-like protein//Viral (Superfamily 1) RNA helicase//Tetraacyldisaccharide-1-P 4'-kinase GO:0009103//GO:0015940//GO:0009245 lipopolysaccharide biosynthetic process//pantothenate biosynthetic process//lipid A biosynthetic process GO:0009029//GO:0005524 tetraacyldisaccharide 4'-kinase activity//ATP binding -- -- KOG1805 DNA replication helicase Cluster-8309.5943 BP_3 29.66 1.54 1220 642929261 XP_008195760.1 268 6.6e-21 PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum]>gi|642929263|ref|XP_008195761.1| PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59430 BP_3 96.71 1.08 4612 642928531 XP_008195362.1 3020 0.0e+00 PREDICTED: transient receptor potential channel pyrexia [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 1952 5.5e-217 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF02254//PF00520//PF13606//PF00023//PF01266//PF07992 TrkA-N domain//Ion transport protein//Ankyrin repeat//Ankyrin repeat//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0006811//GO:0055114//GO:0006813//GO:0055085 ion transport//oxidation-reduction process//potassium ion transport//transmembrane transport GO:0005216//GO:0016491//GO:0005515 ion channel activity//oxidoreductase activity//protein binding GO:0016020 membrane KOG4177 Ankyrin Cluster-8309.59431 BP_3 3.15 0.51 591 751231159 XP_011169122.1 159 1.4e-08 PREDICTED: LOW QUALITY PROTEIN: cubilin [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59432 BP_3 2.00 0.51 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59433 BP_3 13.86 0.72 1226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59438 BP_3 29.00 1.37 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03127 GAT domain GO:0006886 intracellular protein transport -- -- GO:0005622 intracellular -- -- Cluster-8309.5944 BP_3 55.29 2.07 1580 642929261 XP_008195760.1 268 8.6e-21 PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum]>gi|642929263|ref|XP_008195761.1| PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59447 BP_3 1.00 1.58 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59449 BP_3 21.00 22.71 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59451 BP_3 7.00 0.64 822 156389506 XP_001635032.1 411 1.2e-37 predicted protein [Nematostella vectensis]>gi|156222121|gb|EDO42969.1| predicted protein [Nematostella vectensis] 697076005 XM_009654002.1 565 0 Verticillium dahliae VdLs.17 60S ribosomal protein L27-A mRNA K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 O14388 499 3.0e-49 60S ribosomal protein L27-A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpl2701 PE=2 SV=2 PF01777 Ribosomal L27e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0030529 intracellular//ribosome//intracellular ribonucleoprotein complex KOG3418 60S ribosomal protein L27 Cluster-8309.59452 BP_3 19.00 0.58 1863 470395277 XP_004335057.1 942 7.1e-99 hypothetical protein ACA1_097280 [Acanthamoeba castellanii str. Neff]>gi|440791806|gb|ELR13044.1| hypothetical protein ACA1_097280 [Acanthamoeba castellanii str. Neff] 697087575 XM_009658404.1 1851 0 Verticillium dahliae VdLs.17 pyruvate decarboxylase mRNA -- -- -- -- Q0CNV1 1976 3.7e-220 Pyruvate decarboxylase OS=Aspergillus terreus (strain NIH 2624 / FGSC A1156) GN=pdcA PE=3 SV=1 PF02775//PF00676//PF02776//PF00205//PF13292//PF03485 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Dehydrogenase E1 component//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//Thiamine pyrophosphate enzyme, central domain//1-deoxy-D-xylulose-5-phosphate synthase//Arginyl tRNA synthetase N terminal domain GO:0016114//GO:0006560//GO:0006525//GO:0008152//GO:0006694//GO:0006420 terpenoid biosynthetic process//proline metabolic process//arginine metabolic process//metabolic process//steroid biosynthetic process//arginyl-tRNA aminoacylation GO:0004814//GO:0016624//GO:0005524//GO:0003824//GO:0008661//GO:0000287//GO:0030976//GO:0000166 arginine-tRNA ligase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//ATP binding//catalytic activity//1-deoxy-D-xylulose-5-phosphate synthase activity//magnesium ion binding//thiamine pyrophosphate binding//nucleotide binding GO:0005737 cytoplasm KOG1184 Thiamine pyrophosphate-requiring enzyme Cluster-8309.59453 BP_3 18.23 0.86 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59456 BP_3 51.65 0.35 7384 665788269 XP_008559724.1 630 4.3e-62 PREDICTED: uncharacterized protein LOC103579935 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05829//PF04513//PF07851//PF01637//PF01367//PF00580 Adenovirus late L2 mu core protein (Protein X)//Baculovirus polyhedron envelope protein, PEP, C terminus//TMPIT-like protein//Archaeal ATPase//5'-3' exonuclease, C-terminal SAM fold//UvrD/REP helicase N-terminal domain -- -- GO:0003824//GO:0005524//GO:0003677//GO:0005198 catalytic activity//ATP binding//DNA binding//structural molecule activity GO:0019013//GO:0016021//GO:0019028//GO:0019031 viral nucleocapsid//integral component of membrane//viral capsid//viral envelope -- -- Cluster-8309.59458 BP_3 34.91 0.57 3268 642915789 XP_008200078.1 1379 2.6e-149 PREDICTED: uncharacterized protein LOC103314831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.59460 BP_3 13.17 0.43 1784 270016030 EFA12478.1 417 5.1e-38 hypothetical protein TcasGA2_TC001502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03277 163 6.0e-10 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Fragment) OS=Bradysia coprophila PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1075 FOG: Reverse transcriptase Cluster-8309.59462 BP_3 65.09 1.19 2939 642924690 XP_008194399.1 1005 5.6e-106 PREDICTED: probable G-protein coupled receptor Mth-like 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 213 1.6e-15 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002//PF09398 7 transmembrane receptor (Secretin family)//FOP N terminal dimerisation domain GO:0007186//GO:0034453 G-protein coupled receptor signaling pathway//microtubule anchoring GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0005815 integral component of membrane//microtubule organizing center -- -- Cluster-8309.59463 BP_3 238.77 15.53 1033 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59465 BP_3 6.00 0.57 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00301 Rubredoxin -- -- GO:0005506 iron ion binding -- -- -- -- Cluster-8309.59467 BP_3 22.00 0.67 1871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59469 BP_3 3.00 0.85 462 340371588 XP_003384327.1 277 2.3e-22 PREDICTED: 40S ribosomal protein S21-like [Amphimedon queenslandica] 697089290 XM_009659260.1 264 3.44469e-134 Verticillium dahliae VdLs.17 40S ribosomal protein S21 partial mRNA K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 O93798 389 9.7e-37 40S ribosomal protein S21 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=crp-7 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3486 40S ribosomal protein S21 Cluster-8309.59474 BP_3 1.00 0.49 389 313239184 CBY14143.1 228 9.2e-17 unnamed protein product [Oikopleura dioica] 407313393 JX680695.1 323 4.55222e-167 Uncultured bacterium clone LFC61 16S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59485 BP_3 1095.45 25.12 2394 91081457 XP_974014.1 2265 3.6e-252 PREDICTED: probable cytochrome P450 301a1, mitochondrial [Tribolium castaneum]>gi|270006458|gb|EFA02906.1| cytochrome P450 301A1 [Tribolium castaneum] 642920930 XM_968921.2 295 1.1075e-150 PREDICTED: Tribolium castaneum cytochrome P450 301A1 (LOC662845), mRNA -- -- -- -- Q9V6D6 1858 2.3e-206 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0020037//GO:0004497//GO:0005506 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//monooxygenase activity//iron ion binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.59489 BP_3 2.00 0.59 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59491 BP_3 23.75 0.62 2130 189240709 XP_001813711.1 1447 2.2e-157 PREDICTED: acyl-CoA synthetase family member 2, mitochondrial [Tribolium castaneum]>gi|270013541|gb|EFA09989.1| hypothetical protein TcasGA2_TC012154 [Tribolium castaneum] -- -- -- -- -- K00666 K00666 fatty-acyl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00666 Q0P4F7 835 8.5e-88 Acyl-CoA synthetase family member 2, mitochondrial OS=Danio rerio GN=acsf2 PE=2 SV=1 PF08290//PF00501 Hepatitis core protein, putative zinc finger//AMP-binding enzyme GO:0008152//GO:0009405 metabolic process//pathogenesis GO:0003824//GO:0005198 catalytic activity//structural molecule activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.59494 BP_3 36.02 0.65 2979 795009001 XP_011859791.1 556 6.5e-54 PREDICTED: uncharacterized protein LOC105557210, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 135 1.8e-06 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.59496 BP_3 90.04 2.62 1948 189235279 XP_973810.2 1316 3.2e-142 PREDICTED: probable cytochrome P450 4aa1 [Tribolium castaneum] -- -- -- -- -- K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 Q9V7G5 1105 3.8e-119 Probable cytochrome P450 4aa1 OS=Drosophila melanogaster GN=Cyp4aa1 PE=2 SV=2 PF00067//PF03806 Cytochrome P450//AbgT putative transporter family GO:0015814//GO:0006811//GO:1902604//GO:0055114//GO:0015846 p-aminobenzoyl-glutamate transport//ion transport//p-aminobenzoyl-glutamate transmembrane transport//oxidation-reduction process//polyamine transport GO:0015558//GO:0005506//GO:0020037//GO:0016705 p-aminobenzoyl-glutamate uptake transmembrane transporter activity//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.59498 BP_3 16.12 0.67 1455 134131322 BAF49604.1 922 1.2e-96 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 525 5.2e-52 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.59499 BP_3 15.55 1.35 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59500 BP_3 2673.64 23.14 5860 478253532 ENN73850.1 6343 0.0e+00 hypothetical protein YQE_09542, partial [Dendroctonus ponderosae]>gi|546685405|gb|ERL94918.1| hypothetical protein D910_12190 [Dendroctonus ponderosae] 642937163 XM_008200496.1 386 0 PREDICTED: Tribolium castaneum cadherin-89D (LOC658847), mRNA -- -- -- -- Q9VEU1 1638 1.8e-180 Cadherin-89D OS=Drosophila melanogaster GN=Cad89D PE=2 SV=3 PF09107//PF00028 Elongation factor SelB, winged helix//Cadherin domain GO:0001514//GO:0006448//GO:0007156 selenocysteine incorporation//regulation of translational elongation//homophilic cell adhesion via plasma membrane adhesion molecules GO:0003746//GO:0005509//GO:0005525//GO:0003723 translation elongation factor activity//calcium ion binding//GTP binding//RNA binding GO:0005737//GO:0016020//GO:0005840 cytoplasm//membrane//ribosome -- -- Cluster-8309.59501 BP_3 3309.86 24.28 6861 478253532 ENN73850.1 6617 0.0e+00 hypothetical protein YQE_09542, partial [Dendroctonus ponderosae]>gi|546685405|gb|ERL94918.1| hypothetical protein D910_12190 [Dendroctonus ponderosae] 642937163 XM_008200496.1 386 0 PREDICTED: Tribolium castaneum cadherin-89D (LOC658847), mRNA -- -- -- -- Q9VEU1 1638 2.1e-180 Cadherin-89D OS=Drosophila melanogaster GN=Cad89D PE=2 SV=3 PF01857//PF00028//PF09107 Retinoblastoma-associated protein B domain//Cadherin domain//Elongation factor SelB, winged helix GO:0001514//GO:0007156//GO:0051726//GO:0006448 selenocysteine incorporation//homophilic cell adhesion via plasma membrane adhesion molecules//regulation of cell cycle//regulation of translational elongation GO:0003746//GO:0005509//GO:0005525//GO:0003723 translation elongation factor activity//calcium ion binding//GTP binding//RNA binding GO:0016020//GO:0005840//GO:0005737//GO:0005634 membrane//ribosome//cytoplasm//nucleus -- -- Cluster-8309.59502 BP_3 118.54 3.76 1811 675368093 KFM60995.1 197 1.7e-12 hypothetical protein X975_04887, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q69566 133 1.8e-06 Uncharacterized protein U88 OS=Human herpesvirus 6A (strain Uganda-1102) GN=U88 PE=4 SV=1 PF08651 DASH complex subunit Duo1 GO:0007067 mitotic nuclear division -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.59503 BP_3 13395.30 108.49 6243 478253532 ENN73850.1 6595 0.0e+00 hypothetical protein YQE_09542, partial [Dendroctonus ponderosae]>gi|546685405|gb|ERL94918.1| hypothetical protein D910_12190 [Dendroctonus ponderosae] 642937163 XM_008200496.1 374 0 PREDICTED: Tribolium castaneum cadherin-89D (LOC658847), mRNA -- -- -- -- Q9VEU1 1638 1.9e-180 Cadherin-89D OS=Drosophila melanogaster GN=Cad89D PE=2 SV=3 PF00028//PF09107 Cadherin domain//Elongation factor SelB, winged helix GO:0001514//GO:0006448//GO:0007156 selenocysteine incorporation//regulation of translational elongation//homophilic cell adhesion via plasma membrane adhesion molecules GO:0003746//GO:0005509//GO:0005525//GO:0003723 translation elongation factor activity//calcium ion binding//GTP binding//RNA binding GO:0005737//GO:0016020//GO:0005840 cytoplasm//membrane//ribosome -- -- Cluster-8309.59519 BP_3 30.00 0.65 2515 767812875 AJT58471.1 2730 4.5e-306 cytochrome oxidase subunit I, partial (mitochondrion) [Anthomyza pleuralis] 768311754 CP010982.1 2480 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- Q2TW34 3109 0.0e+00 Catalase-peroxidase OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=katG PE=3 SV=1 PF00141 Peroxidase GO:0006979//GO:0006804//GO:0055114 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0020037//GO:0004601 heme binding//peroxidase activity -- -- -- -- Cluster-8309.59520 BP_3 3.00 0.61 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59521 BP_3 5.00 0.59 700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59526 BP_3 8.00 0.34 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59530 BP_3 17.79 1.52 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01022 Bacterial regulatory protein, arsR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.59532 BP_3 5761.86 118.52 2635 91083957 XP_975021.1 800 2.9e-82 PREDICTED: caldesmon [Tribolium castaneum]>gi|270006722|gb|EFA03170.1| hypothetical protein TcasGA2_TC013090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09002 147 6.3e-08 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF04513//PF14372//PF00836//PF01442 Baculovirus polyhedron envelope protein, PEP, C terminus//Domain of unknown function (DUF4413)//Stathmin family//Apolipoprotein A1/A4/E domain GO:0031110//GO:0006869//GO:0042157 regulation of microtubule polymerization or depolymerization//lipid transport//lipoprotein metabolic process GO:0005198//GO:0003677//GO:0008289 structural molecule activity//DNA binding//lipid binding GO:0005576//GO:0019031//GO:0019028 extracellular region//viral envelope//viral capsid -- -- Cluster-8309.59538 BP_3 27.21 1.28 1319 270012928 EFA09376.1 157 5.3e-08 hypothetical protein TcasGA2_TC001937 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08546 Ketopantoate reductase PanE/ApbA C terminal GO:0055114 oxidation-reduction process GO:0016491//GO:0050661 oxidoreductase activity//NADP binding -- -- -- -- Cluster-8309.59539 BP_3 2.00 0.32 592 632960150 XP_007896031.1 295 2.4e-24 PREDICTED: aflatoxin B1 aldehyde reductase member 2-like [Callorhinchus milii] 768311754 CP010982.1 577 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence K15303 AKR7 aflatoxin B1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K15303 Q8CG45 277 1.2e-23 Aflatoxin B1 aldehyde reductase member 2 OS=Rattus norvegicus GN=Akr7a2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59541 BP_3 272.06 3.52 4022 642921912 XP_008192941.1 204 5.8e-13 PREDICTED: uncharacterized protein LOC103312898 [Tribolium castaneum]>gi|270007368|gb|EFA03816.1| hypothetical protein TcasGA2_TC013930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12297 Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- -- -- -- -- Cluster-8309.59543 BP_3 260.61 3.41 3971 642921912 XP_008192941.1 204 5.7e-13 PREDICTED: uncharacterized protein LOC103312898 [Tribolium castaneum]>gi|270007368|gb|EFA03816.1| hypothetical protein TcasGA2_TC013930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00876//PF12297 Innexin//Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- GO:0005921 gap junction -- -- Cluster-8309.59549 BP_3 3.00 0.60 532 -- -- -- -- -- 761231940 KM881643.1 532 0 Oryza officinalis chloroplast, complete genome -- -- -- -- Q1KXP9 201 7.0e-15 Putative uncharacterized protein ycf15 OS=Helianthus annuus GN=ycf15-A PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59552 BP_3 15.00 0.51 1718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59554 BP_3 1.00 1.30 317 642917952 XP_008198956.1 169 5.2e-10 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59559 BP_3 11.34 0.38 1746 270015294 EFA11742.1 811 1.0e-83 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF05434//PF03836 Zinc finger, C2H2 type//TMEM9//RasGAP C-terminus GO:0007264 small GTPase mediated signal transduction GO:0005096//GO:0046872 GTPase activator activity//metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.59561 BP_3 78.63 2.06 2133 642924692 XP_008194400.1 969 6.0e-102 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS77 200 3.7e-14 Probable G-protein coupled receptor Mth-like 6 OS=Drosophila melanogaster GN=mthl6 PE=3 SV=2 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.59566 BP_3 2.00 0.73 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59567 BP_3 2.00 0.75 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5957 BP_3 67.79 3.00 1380 270012759 EFA09207.1 391 4.1e-35 serine protease P66 [Tribolium castaneum] -- -- -- -- -- K01344 PROC protein C (activated) http://www.genome.jp/dbget-bin/www_bget?ko:K01344 P05049 245 1.4e-19 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59574 BP_3 28.14 1.92 998 189242304 XP_001808377.1 246 1.9e-18 PREDICTED: uncharacterized protein LOC100141613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08492 SRP72 RNA-binding domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle -- -- Cluster-8309.59575 BP_3 127.25 2.38 2866 478253880 ENN74172.1 240 2.8e-17 hypothetical protein YQE_09145, partial [Dendroctonus ponderosae]>gi|546684689|gb|ERL94306.1| hypothetical protein D910_11587 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59578 BP_3 2.00 0.86 403 607368087 EZA62206.1 164 2.5e-09 hypothetical protein X777_02832, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5958 BP_3 8.81 0.36 1470 642912421 XP_008193352.1 262 4.0e-20 PREDICTED: serine protease snake-like [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q9VWU1 196 7.3e-14 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59583 BP_3 155.26 6.57 1431 642932154 XP_975375.2 712 2.6e-72 PREDICTED: uncharacterized protein LOC664273 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12568//PF13673//PF08445//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.59584 BP_3 11.74 0.46 1510 642932154 XP_975375.2 596 7.6e-59 PREDICTED: uncharacterized protein LOC664273 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13673//PF08445//PF00583//PF13508//PF12568 Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- -- -- Cluster-8309.59590 BP_3 12.02 0.62 1229 607356256 EZA50796.1 1109 2.0e-118 Teneurin-3 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- O61307 742 3.0e-77 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF04863 Alliinase EGF-like domain -- -- GO:0016846 carbon-sulfur lyase activity -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.59592 BP_3 70.28 2.62 1583 546683069 ERL92930.1 479 2.9e-45 hypothetical protein D910_10235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9JL89 209 2.5e-15 Ninjurin-2 OS=Mus musculus GN=Ninj2 PE=2 SV=1 PF01545//PF10192//PF02990//PF04923 Cation efflux family//Rhodopsin-like GPCR transmembrane domain//Endomembrane protein 70//Ninjurin GO:0019236//GO:0007155//GO:0006812//GO:0007186//GO:0042246//GO:0055085 response to pheromone//cell adhesion//cation transport//G-protein coupled receptor signaling pathway//tissue regeneration//transmembrane transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.59598 BP_3 136.00 3.42 2208 642915509 XP_008190647.1 1285 1.4e-138 PREDICTED: glomulin [Tribolium castaneum]>gi|270003856|gb|EFA00304.1| hypothetical protein TcasGA2_TC003139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92990 557 1.5e-55 Glomulin OS=Homo sapiens GN=GLMN PE=1 SV=2 PF01844 HNH endonuclease -- -- GO:0004519//GO:0003676 endonuclease activity//nucleic acid binding -- -- -- -- Cluster-8309.59603 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59604 BP_3 22.98 0.63 2056 478265941 ENN82629.1 335 1.9e-28 hypothetical protein YQE_01003, partial [Dendroctonus ponderosae]>gi|478270115|gb|ENN83460.1| hypothetical protein YQE_00179, partial [Dendroctonus ponderosae]>gi|546671649|gb|ERL83871.1| hypothetical protein D910_01141, partial [Dendroctonus ponderosae]>gi|546675083|gb|ERL86338.1| hypothetical protein D910_03746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9ERS4 218 2.9e-16 Pleckstrin homology domain-containing family A member 3 OS=Mus musculus GN=Plekha3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1737 Oxysterol-binding protein Cluster-8309.59605 BP_3 9.82 0.39 1507 189235509 XP_969871.2 1061 9.1e-113 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 597 2.4e-60 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3621 WD40 repeat-containing protein Cluster-8309.59609 BP_3 4.13 0.32 909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09377 SBDS protein C-terminal domain GO:0042254 ribosome biogenesis -- -- -- -- -- -- Cluster-8309.59612 BP_3 51.00 1.38 2074 645020637 XP_008207240.1 197 1.9e-12 PREDICTED: uncharacterized protein LOC103316246 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59618 BP_3 51.29 0.89 3068 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59619 BP_3 51.00 2.14 1443 642929134 XP_008195706.1 1075 2.1e-114 PREDICTED: engrailed isoform X1 [Tribolium castaneum] 642929133 XM_008197484.1 221 9.04879e-110 PREDICTED: Tribolium castaneum engrailed (En), transcript variant X1, mRNA K09319 EN homeobox protein engrailed http://www.genome.jp/dbget-bin/www_bget?ko:K09319 P27610 668 1.3e-68 Homeobox protein invected OS=Bombyx mori GN=INV PE=2 SV=1 PF05920//PF01140//PF00046 Homeobox KN domain//Matrix protein (MA), p15//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005198 DNA binding//structural molecule activity GO:0019028 viral capsid KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.59622 BP_3 257.58 1.22 10430 270011730 EFA08178.1 1354 6.7e-146 hypothetical protein TcasGA2_TC005805 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TN88 337 2.3e-29 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF06160//PF00520//PF05393 Septation ring formation regulator, EzrA//Ion transport protein//Human adenovirus early E3A glycoprotein GO:0055085//GO:0006811//GO:0000921 transmembrane transport//ion transport//septin ring assembly GO:0005216 ion channel activity GO:0016020//GO:0016021//GO:0005940 membrane//integral component of membrane//septin ring KOG3599 Ca2+-modulated nonselective cation channel polycystin Cluster-8309.59628 BP_3 59.79 1.42 2319 282847463 NP_001164280.1 2233 1.8e-248 archipelago [Tribolium castaneum] 532104130 XM_005337603.1 179 3.26855e-86 PREDICTED: Spermophilus tridecemlineatus F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7), transcript variant X3, mRNA K10260 FBXW7, SEL10 F-box and WD-40 domain protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10260 Q9VZF4 1732 9.0e-192 F-box/WD repeat-containing protein 7 OS=Drosophila melanogaster GN=ago PE=1 SV=1 PF12937//PF06881//PF00400//PF00646 F-box-like//RNA polymerase II transcription factor SIII (Elongin) subunit A//WD domain, G-beta repeat//F-box domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.59631 BP_3 2.00 0.55 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59634 BP_3 15.51 0.49 1824 531446277 AGT57843.1 1205 2.2e-129 cytochrome P450 314a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10723 SHD, CYP314A1 ecdysone 20-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K10723 Q9VUF8 715 6.0e-74 Ecdysone 20-monooxygenase OS=Drosophila melanogaster GN=shd PE=1 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.59635 BP_3 250.40 9.10 1618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF04636 Presenilin//PA26 p53-induced protein (sestrin) GO:1901031 regulation of response to reactive oxygen species GO:0004190 aspartic-type endopeptidase activity GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.59639 BP_3 139.00 9.51 996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59642 BP_3 10.43 0.37 1639 478253172 ENN73543.1 154 1.5e-07 hypothetical protein YQE_09794, partial [Dendroctonus ponderosae]>gi|546678923|gb|ERL89461.1| hypothetical protein D910_06828 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF04988//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.59645 BP_3 5.00 0.50 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59649 BP_3 64.56 1.66 2163 675379531 KFM72433.1 475 1.2e-44 Zinc finger protein 99, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 441 4.2e-42 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF00096//PF13465//PF13639//PF13912//PF01475//PF17123//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Ring finger domain//C2H2-type zinc finger//Ferric uptake regulator family//RING-like zinc finger//BED zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0003700//GO:0046872//GO:0005515 zinc ion binding//DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.5965 BP_3 17.72 0.60 1721 91078830 XP_971270.1 763 3.7e-78 PREDICTED: metallophosphoesterase domain-containing protein 1 [Tribolium castaneum]>gi|270004125|gb|EFA00573.1| hypothetical protein TcasGA2_TC003443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18161 345 4.5e-31 UPF0046 protein C25E10.12 OS=Caenorhabditis elegans GN=C25E10.12 PE=3 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3947 Phosphoesterases Cluster-8309.59650 BP_3 2.00 0.42 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59653 BP_3 32073.00 4476.92 637 156550115 XP_001605834.1 141 1.8e-06 PREDICTED: protein vestigial [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02653 Branched-chain amino acid transport system / permease component GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.59654 BP_3 44.89 1.32 1935 546677436 ERL88273.1 461 4.4e-43 hypothetical protein D910_05660 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.59655 BP_3 8.80 0.44 1264 642932789 XP_008196985.1 332 2.6e-28 PREDICTED: fibroblast growth factor 1-like [Tribolium castaneum]>gi|270012810|gb|EFA09258.1| fibroblast growth factor 1 [Tribolium castaneum] -- -- -- -- -- K18496 FGF1 fibroblast growth factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18496 Q7SIF8 196 6.3e-14 Fibroblast growth factor 1 (Fragment) OS=Notophthalmus viridescens GN=fgf1 PE=1 SV=1 PF00340//PF00167//PF06268 Interleukin-1 / 18//Fibroblast growth factor//Fascin domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083//GO:0051015//GO:0030674 growth factor activity//actin filament binding//protein binding, bridging GO:0005615 extracellular space -- -- Cluster-8309.5966 BP_3 35.45 0.66 2872 642912455 XP_008200869.1 1639 1.7e-179 PREDICTED: uncharacterized protein LOC660090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C761 385 1.7e-35 WD repeat-containing protein 60 OS=Mus musculus GN=Wdr60 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.59661 BP_3 39.13 0.41 4930 642936285 XP_008198383.1 2232 4.9e-248 PREDICTED: protein tincar isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B91 453 3.9e-43 Protein tincar OS=Drosophila melanogaster GN=tinc PE=2 SV=1 PF00599 Influenza Matrix protein (M2) GO:0015992 proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036 host cell membrane//virion membrane -- -- Cluster-8309.59663 BP_3 45.00 1.57 1672 390994295 AFM37312.1 2553 1.0e-285 immunoglobulin mu heavy chain, partial [Homo sapiens] 33873883 BC011857.2 1661 0 Homo sapiens immunoglobulin heavy constant mu, mRNA (cDNA clone IMAGE:4309235) -- -- -- -- P01871 2257 8.6e-253 Ig mu chain C region OS=Homo sapiens GN=IGHM PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.59669 BP_3 297.01 3.63 4237 820805580 AKG92781.1 3024 0.0e+00 trachealess [Leptinotarsa decemlineata] 820805579 KP147944.1 578 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1104 1.1e-118 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF08447//PF04551//PF00989 PAS fold//GcpE protein//PAS fold GO:0006355//GO:0055114//GO:0016114 regulation of transcription, DNA-templated//oxidation-reduction process//terpenoid biosynthetic process GO:0005515//GO:0046429 protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity -- -- -- -- Cluster-8309.59670 BP_3 146.61 1.64 4595 91083873 XP_974306.1 619 5.0e-61 PREDICTED: uncharacterized protein LOC663153 [Tribolium castaneum]>gi|270007945|gb|EFA04393.1| hypothetical protein TcasGA2_TC014692 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70617 230 2.6e-17 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF04923//PF07469 Ninjurin//Domain of unknown function (DUF1518) GO:0042246//GO:0007155 tissue regeneration//cell adhesion -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.59672 BP_3 52.51 4.50 854 449083364 NP_001263355.1 647 5.2e-65 dehydrogenase/reductase SDR family member 4 [Tribolium castaneum]>gi|270003836|gb|EFA00284.1| hypothetical protein TcasGA2_TC003117 [Tribolium castaneum] -- -- -- -- -- K11147 DHRS4 dehydrogenase/reductase SDR family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11147 Q9GKX2 457 2.3e-44 Dehydrogenase/reductase SDR family member 4 (Fragment) OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1 PF00106//PF02737//PF01370 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0055114//GO:0006552//GO:0006554//GO:0006568//GO:0006631//GO:0008152//GO:0006633//GO:0018874//GO:0006574//GO:0006550 oxidation-reduction process//leucine catabolic process//lysine catabolic process//tryptophan metabolic process//fatty acid metabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//valine catabolic process//isoleucine catabolic process GO:0003857//GO:0016491//GO:0003824//GO:0050662 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//catalytic activity//coenzyme binding -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.59677 BP_3 950.79 19.25 2672 642920552 XP_008192402.1 184 8.0e-11 PREDICTED: glutamic acid-rich protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59678 BP_3 2560.37 34.08 3913 270005279 EFA01727.1 280 8.7e-22 hypothetical protein TcasGA2_TC007307 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59679 BP_3 1906.10 25.81 3851 270005279 EFA01727.1 280 8.5e-22 hypothetical protein TcasGA2_TC007307 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59685 BP_3 6912.28 127.78 2899 189237843 XP_974681.2 3051 0.0e+00 PREDICTED: advillin isoform X1 [Tribolium castaneum]>gi|270006740|gb|EFA03188.1| hypothetical protein TcasGA2_TC013108 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75366 1233 8.2e-134 Advillin OS=Homo sapiens GN=AVIL PE=1 SV=3 PF02209//PF16093 Villin headpiece domain//Proteasome assembly chaperone 4 GO:0007010//GO:0043248 cytoskeleton organization//proteasome assembly GO:0003779 actin binding -- -- KOG0443 Actin regulatory proteins (gelsolin/villin family) Cluster-8309.59686 BP_3 1.00 0.39 414 -- -- -- -- -- 768311755 CP010983.1 405 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- Q6FLP9 438 1.8e-42 Mannan endo-1,6-alpha-mannosidase DCW1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) GN=DCW1 PE=3 SV=1 PF00718 Polyomavirus coat protein -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.59687 BP_3 134.37 0.70 9597 642930197 XP_008196297.1 4288 0.0e+00 PREDICTED: protein jagged-1b isoform X2 [Tribolium castaneum] 817218870 XM_012429812.1 45 4.22702e-11 PREDICTED: Orussus abietinus protein jagged-1 (LOC105702323), mRNA K06052 JAGGED jagged http://www.genome.jp/dbget-bin/www_bget?ko:K06052 Q90Y54 1937 6.3e-215 Protein jagged-1b OS=Danio rerio GN=jag1b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59697 BP_3 19.97 0.49 2268 270014679 EFA11127.1 385 3.3e-34 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 256 1.3e-20 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5970 BP_3 57.00 1.84 1785 642938772 XP_008199882.1 198 1.3e-12 PREDICTED: uncharacterized protein LOC103314778 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05983 MED7 protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.59705 BP_3 12.35 0.56 1356 642939895 XP_008200229.1 534 1.1e-51 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] -- -- -- -- -- K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q06124 479 1.0e-46 Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens GN=PTPN11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59708 BP_3 33.39 0.60 2966 546685576 ERL95063.1 2536 1.7e-283 hypothetical protein D910_12333 [Dendroctonus ponderosae] 564241862 XM_006277680.1 37 3.62874e-07 PREDICTED: Alligator mississippiensis REV1, polymerase (DNA directed) (REV1), transcript variant X3, mRNA K03515 REV1 DNA repair protein REV1 http://www.genome.jp/dbget-bin/www_bget?ko:K03515 Q4KWZ7 995 3.3e-106 DNA repair protein REV1 OS=Gallus gallus GN=REV1 PE=2 SV=1 PF11799//PF00961//PF00817 impB/mucB/samB family C-terminal domain//LAGLIDADG endonuclease//impB/mucB/samB family GO:0006281 DNA repair GO:0003684//GO:0004519 damaged DNA binding//endonuclease activity -- -- KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase Cluster-8309.5971 BP_3 146.87 3.89 2113 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59710 BP_3 72.66 0.92 4099 478263167 ENN81560.1 2839 0.0e+00 hypothetical protein YQE_02089, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NEN0 734 8.5e-76 Armadillo repeat-containing protein 2 OS=Homo sapiens GN=ARMC2 PE=2 SV=4 PF06372//PF00514 Gemin6 protein//Armadillo/beta-catenin-like repeat GO:0000245 spliceosomal complex assembly GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.59712 BP_3 86.90 1.09 4118 676426419 XP_009044617.1 755 7.6e-77 hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea]>gi|556116066|gb|ESP04718.1| hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 688 1.8e-70 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF16622//PF13465//PF00096//PF00130//PF01842 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//ACT domain GO:0008152//GO:0035556 metabolic process//intracellular signal transduction GO:0016597//GO:0046872 amino acid binding//metal ion binding -- -- -- -- Cluster-8309.59715 BP_3 5.00 0.32 1051 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59716 BP_3 8.07 0.60 935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59717 BP_3 4.00 1.56 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59721 BP_3 103.73 3.55 1701 852800404 XP_012889433.1 663 1.5e-66 PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800407|ref|XP_012889434.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800410|ref|XP_012889435.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800413|ref|XP_012889436.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800416|ref|XP_012889437.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii] 533131911 XM_005380929.1 41 1.23342e-09 PREDICTED: Chinchilla lanigera zinc finger protein 133 (Znf133), transcript variant X9, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 631 3.1e-64 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF00096//PF00830//PF17123//PF13912//PF01780 Zinc-finger double domain//Zinc finger, C2H2 type//Ribosomal L28 family//RING-like zinc finger//C2H2-type zinc finger//Ribosomal L37ae protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0046872//GO:0008270//GO:0003735//GO:0005515 metal ion binding//zinc ion binding//structural constituent of ribosome//protein binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.59727 BP_3 1.00 0.36 426 546682201 ERL92170.1 256 5.7e-20 hypothetical protein D910_09490 [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W092 205 1.9e-15 Probable chitinase 2 OS=Drosophila melanogaster GN=Cht2 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.59736 BP_3 41.95 0.70 3177 270012054 EFA08502.1 1928 5.6e-213 hypothetical protein TcasGA2_TC006154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0PV50 383 3.3e-35 Toll-like receptor 3 OS=Boselaphus tragocamelus GN=TLR3 PE=2 SV=1 PF01582//PF00560//PF13676//PF13855 TIR domain//Leucine Rich Repeat//TIR domain//Leucine rich repeat GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.5974 BP_3 13.26 1.15 848 478253107 ENN73480.1 325 1.1e-27 hypothetical protein YQE_09905, partial [Dendroctonus ponderosae] -- -- -- -- -- K02349 POLQ DNA polymerase theta http://www.genome.jp/dbget-bin/www_bget?ko:K02349 O18475 272 6.5e-23 DNA polymerase theta OS=Drosophila melanogaster GN=mus308 PE=1 SV=1 PF00476 DNA polymerase family A GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.59740 BP_3 151.12 1.08 7015 -- -- -- -- -- 642940399 XM_008202325.1 70 3.90736e-25 PREDICTED: Tribolium castaneum chitin deacetylase 5 (Cda5), transcript variant X8, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59741 BP_3 27.00 1.69 1064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13495 Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.59743 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59744 BP_3 36.87 0.33 5684 270005284 EFA01732.1 1247 9.3e-134 hypothetical protein TcasGA2_TC007325 [Tribolium castaneum] -- -- -- -- -- K18035 PTPRO receptor-type tyrosine-protein phosphatase O http://www.genome.jp/dbget-bin/www_bget?ko:K18035 P35992 468 8.2e-45 Tyrosine-protein phosphatase 10D OS=Drosophila melanogaster GN=Ptp10D PE=1 SV=4 PF00041//PF00102 Fibronectin type III domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515 protein tyrosine phosphatase activity//protein binding -- -- -- -- Cluster-8309.59746 BP_3 7.00 0.77 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59750 BP_3 104.35 2.26 2517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14604//PF00341 Variant SH3 domain//PDGF/VEGF domain GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0005515//GO:0008083 protein binding//growth factor activity GO:0016020 membrane -- -- Cluster-8309.59752 BP_3 32.65 0.62 2843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341//PF14604 PDGF/VEGF domain//Variant SH3 domain GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0005515//GO:0008083 protein binding//growth factor activity GO:0016020 membrane -- -- Cluster-8309.59754 BP_3 1483.58 109.80 943 290909033 ADD70031.1 343 1.0e-29 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395//PF02416 PBP/GOBP family//mttA/Hcf106 family GO:0015031 protein transport GO:0005549//GO:0008565 odorant binding//protein transporter activity -- -- -- -- Cluster-8309.59755 BP_3 24.51 1.05 1413 290909033 ADD70031.1 219 3.7e-15 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02416//PF01395 mttA/Hcf106 family//PBP/GOBP family GO:0015031 protein transport GO:0008565//GO:0005549 protein transporter activity//odorant binding -- -- -- -- Cluster-8309.59757 BP_3 2.00 2.28 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59758 BP_3 16.00 1.12 978 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59759 BP_3 33.60 1.67 1260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59766 BP_3 57.99 0.83 3655 642939164 XP_008200361.1 2189 3.5e-243 PREDICTED: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1 [Tribolium castaneum]>gi|270016358|gb|EFA12804.1| hypothetical protein TcasGA2_TC001867 [Tribolium castaneum] 752875257 XM_011256672.1 68 2.62223e-24 PREDICTED: Camponotus floridanus alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC105250520), transcript variant X5, mRNA K00736 MGAT2 alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00736 Q921V5 843 1.7e-88 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat2 PE=2 SV=1 PF01121//PF02367//PF06414//PF05060//PF00437 Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//N-acetylglucosaminyltransferase II (MGAT2)//Type II/IV secretion system protein GO:0002949//GO:0015937//GO:0009312//GO:0015940//GO:0006810 tRNA threonylcarbamoyladenosine modification//coenzyme A biosynthetic process//oligosaccharide biosynthetic process//pantothenate biosynthetic process//transport GO:0016301//GO:0004140//GO:0005524//GO:0008455 kinase activity//dephospho-CoA kinase activity//ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GO:0005795//GO:0016021 Golgi stack//integral component of membrane KOG2791 N-acetylglucosaminyltransferase Cluster-8309.59773 BP_3 17.00 0.67 1511 91086405 XP_966655.1 405 1.1e-36 PREDICTED: retinol dehydrogenase 12 [Tribolium castaneum]>gi|270010298|gb|EFA06746.1| hypothetical protein TcasGA2_TC009680 [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8BYK4 239 7.8e-19 Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2 SV=1 PF00106//PF12242 short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.59776 BP_3 2.00 0.73 423 642920948 XP_008192626.1 251 2.1e-19 PREDICTED: amyloid beta A4 precursor protein-binding family B member 2-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59777 BP_3 30.18 0.47 3382 91083749 XP_971342.1 1218 1.3e-130 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 890 5.7e-94 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.59778 BP_3 17.18 0.34 2749 642924394 XP_008194277.1 1649 1.1e-180 PREDICTED: MPN domain-containing protein CG4751 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 707 7.7e-73 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.5978 BP_3 24.54 0.91 1593 91091418 XP_971893.1 820 8.5e-85 PREDICTED: protein-associating with the carboxyl-terminal domain of ezrin [Tribolium castaneum]>gi|270000964|gb|EEZ97411.1| hypothetical protein TcasGA2_TC011240 [Tribolium castaneum] -- -- -- -- -- K17542 SCYL3 SCY1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17542 Q9DBQ7 252 2.6e-20 Protein-associating with the carboxyl-terminal domain of ezrin OS=Mus musculus GN=Scyl3 PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1243 Protein kinase Cluster-8309.59788 BP_3 133.00 19.12 627 817068587 XP_012256239.1 231 6.7e-17 PREDICTED: uncharacterized protein LOC105686192 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q17015 203 4.8e-15 Cuticle protein OS=Anopheles gambiae GN=Ccp84Ab PE=2 SV=3 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.59789 BP_3 6.00 7.22 321 642930002 XP_975673.2 138 2.1e-06 PREDICTED: ice-structuring glycoprotein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59791 BP_3 14.55 0.41 2000 91079010 XP_974804.1 271 4.9e-21 PREDICTED: putative inositol monophosphatase 3 [Tribolium castaneum]>gi|270004173|gb|EFA00621.1| hypothetical protein TcasGA2_TC003497 [Tribolium castaneum] -- -- -- -- -- K15759 IMPAD1, IMPA3 inositol monophosphatase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15759 Q29JH0 181 5.5e-12 Putative inositol monophosphatase 3 OS=Drosophila pseudoobscura pseudoobscura GN=GA13929 PE=3 SV=2 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.59792 BP_3 15.11 0.31 2618 270006980 EFA03428.1 591 5.0e-58 hypothetical protein TcasGA2_TC013417 [Tribolium castaneum] -- -- -- -- -- K12021 TRIM45 tripartite motif-containing protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K12021 Q6PFY8 276 6.9e-23 Tripartite motif-containing protein 45 OS=Mus musculus GN=Trim45 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59794 BP_3 11.00 1.30 698 546675362 ERL86572.1 355 3.1e-31 hypothetical protein D910_03979 [Dendroctonus ponderosae] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 Q9GKS6 189 2.3e-13 Probable phospholipid-transporting ATPase VD (Fragment) OS=Macaca fascicularis GN=ATP10D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0206 P-type ATPase Cluster-8309.598 BP_3 36.84 0.38 4916 642917076 XP_967651.3 1148 2.4e-122 PREDICTED: GTP-binding protein Di-Ras1 [Tribolium castaneum]>gi|270004334|gb|EFA00782.1| hypothetical protein TcasGA2_TC003668 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R6S2 298 3.7e-25 GTP-binding protein Di-Ras2 OS=Pongo abelii GN=DIRAS2 PE=2 SV=1 PF01443//PF01926//PF03193//PF08477//PF00025//PF00071 Viral (Superfamily 1) RNA helicase//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.59800 BP_3 38.89 0.91 2362 91087599 XP_972227.1 569 1.6e-55 PREDICTED: uncharacterized protein LOC660940 [Tribolium castaneum]>gi|270010702|gb|EFA07150.1| hypothetical protein TcasGA2_TC010144 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59801 BP_3 76.80 2.02 2128 91082815 XP_968750.1 1726 1.0e-189 PREDICTED: beta-galactoside alpha-2,6-sialyltransferase 1 [Tribolium castaneum]>gi|270007588|gb|EFA04036.1| hypothetical protein TcasGA2_TC014265 [Tribolium castaneum] -- -- -- -- -- K00779 SIAT2, ST6GAL2 beta-galactoside alpha2,6-sialyltransferase (sialyltransferase 2) http://www.genome.jp/dbget-bin/www_bget?ko:K00779 Q92182 682 4.7e-70 Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Gallus gallus GN=ST6GAL1 PE=2 SV=1 PF01192//PF00777 RNA polymerase Rpb6//Glycosyltransferase family 29 (sialyltransferase) GO:0006144//GO:0006351//GO:0006206//GO:0006486 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//protein glycosylation GO:0008373//GO:0003677//GO:0003899 sialyltransferase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0030173 nucleolus//integral component of Golgi membrane KOG2692 Sialyltransferase Cluster-8309.59804 BP_3 9.83 0.49 1253 642935650 XP_008198099.1 683 5.2e-69 PREDICTED: post-GPI attachment to proteins factor 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68EV0 410 9.6e-39 Post-GPI attachment to proteins factor 3 OS=Xenopus laevis GN=pgap3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2970 Predicted membrane protein Cluster-8309.59805 BP_3 72.72 4.19 1128 642935650 XP_008198099.1 1181 8.3e-127 PREDICTED: post-GPI attachment to proteins factor 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K0P4 748 5.5e-78 Post-GPI attachment to proteins factor 3 OS=Drosophila melanogaster GN=PGAP3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2970 Predicted membrane protein Cluster-8309.59806 BP_3 9.00 1.90 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59807 BP_3 22.78 1.22 1189 642935650 XP_008198099.1 683 4.9e-69 PREDICTED: post-GPI attachment to proteins factor 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68EV0 410 9.1e-39 Post-GPI attachment to proteins factor 3 OS=Xenopus laevis GN=pgap3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2970 Predicted membrane protein Cluster-8309.59810 BP_3 112.85 1.06 5411 642923601 XP_008193575.1 651 1.1e-64 PREDICTED: uncharacterized protein LOC103313062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 169 3.7e-10 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF15957//PF00097//PF14634//PF13639//PF11789 Commissureless//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Ring finger domain//Zinc-finger of the MIZ type in Nse subunit GO:0007411 axon guidance GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- -- -- Cluster-8309.59815 BP_3 17.19 0.76 1377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59817 BP_3 11.67 1.66 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59821 BP_3 117.57 2.42 2633 642939704 XP_008201400.1 252 1.0e-18 PREDICTED: uncharacterized protein LOC103315176 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59823 BP_3 51.50 0.52 5101 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15178//PF02201 Mitochondrial import receptor subunit TOM5 homolog//SWIB/MDM2 domain -- -- GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.59825 BP_3 1.00 0.47 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59827 BP_3 114.67 2.25 2743 332374612 AEE62447.1 1251 1.5e-134 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q52KD1 756 1.6e-78 Sodium/bile acid cotransporter 7-B OS=Xenopus laevis GN=slc10a7-b PE=2 SV=1 PF01321//PF01758 Creatinase/Prolidase N-terminal domain//Sodium Bile acid symporter family -- -- GO:0016787 hydrolase activity GO:0016020 membrane -- -- Cluster-8309.59831 BP_3 34.62 0.38 4637 704301209 XP_010162934.1 1430 4.6e-155 PREDICTED: uncharacterized protein LOC104522366, partial [Caprimulgus carolinensis] 404312705 AC253545.1 4144 0 Prunus persica clone JGIBIXB-13E11, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59832 BP_3 60.96 0.99 3274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04066 Multiple resistance and pH regulation protein F (MrpF / PhaF) GO:0006811//GO:0034220 ion transport//ion transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.59833 BP_3 18.14 0.33 2906 641659262 XP_008181029.1 652 4.7e-65 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- O96006 210 3.5e-15 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 PF02892//PF05699 BED zinc finger//hAT family C-terminal dimerisation region -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- KOG1121 Tam3-transposase (Ac family) Cluster-8309.59834 BP_3 10.00 11.40 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59835 BP_3 12.00 12.76 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59838 BP_3 2.50 0.38 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59839 BP_3 6.83 0.51 937 91093076 XP_968784.1 641 2.9e-64 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 539 7.9e-54 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.59840 BP_3 18.00 0.41 2430 91086951 XP_972888.1 813 8.4e-84 PREDICTED: segmentation polarity homeobox protein engrailed [Tribolium castaneum]>gi|270010997|gb|EFA07445.1| engrailed [Tribolium castaneum] 170049340 XM_001855475.1 125 3.57602e-56 Culex quinquefasciatus segmentation polarity homeobox protein engrailed, mRNA K09319 EN homeobox protein engrailed http://www.genome.jp/dbget-bin/www_bget?ko:K09319 P27609 471 1.6e-45 Segmentation polarity homeobox protein engrailed OS=Bombyx mori GN=en PE=2 SV=1 PF05920//PF02117//PF16045//PF00046 Homeobox KN domain//Serpentine type 7TM GPCR chemoreceptor Sra//LisH//Homeobox domain GO:0006355//GO:0007186//GO:0007606 regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus GO:0004930//GO:0003677//GO:0005515 G-protein coupled receptor activity//DNA binding//protein binding GO:0016021 integral component of membrane KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.59845 BP_3 37.50 0.76 2680 642921104 XP_008192691.1 1190 1.8e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.7e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF09726//PF02535//PF15678//PF05854//PF05279//PF04882//PF02932//PF11744 Transmembrane protein//ZIP Zinc transporter//Centriole duplication and mitotic chromosome congression//Non-histone chromosomal protein MC1//Aspartyl beta-hydroxylase N-terminal region//Peroxin-3//Neurotransmitter-gated ion-channel transmembrane region//Aluminium activated malate transporter GO:0006811//GO:0042262//GO:0030001//GO:0055085//GO:0007031//GO:0090307//GO:0015743 ion transport//DNA protection//metal ion transport//transmembrane transport//peroxisome organization//mitotic spindle assembly//malate transport GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005779//GO:0016021 membrane//integral component of peroxisomal membrane//integral component of membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.59855 BP_3 16.64 0.65 1530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59857 BP_3 38.69 1.15 1919 642925210 XP_008194470.1 1643 3.8e-180 PREDICTED: fatty acyl-CoA reductase 1 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 987 1.8e-105 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01118//PF01073//PF01370 Male sterility protein//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//estrogen metabolic process GO:0080019//GO:0016620//GO:0003824//GO:0050662//GO:0003854//GO:0016616//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.5986 BP_3 13.00 0.39 1894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59861 BP_3 39.00 13.16 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59862 BP_3 312.54 14.18 1354 642927913 XP_008195445.1 1274 1.6e-137 PREDICTED: tRNA selenocysteine 1-associated protein 1 isoform X1 [Tribolium castaneum]>gi|270010282|gb|EFA06730.1| hypothetical protein TcasGA2_TC009661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1RMJ7 508 4.5e-50 tRNA selenocysteine 1-associated protein 1 OS=Bos taurus GN=TRNAU1AP PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG0118 FOG: RRM domain Cluster-8309.59863 BP_3 56.81 1.00 3027 642915467 XP_008190631.1 321 1.2e-26 PREDICTED: intraflagellar transport protein 43 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF15305 Presenilin//Intraflagellar transport protein 43 -- -- GO:0004190 aspartic-type endopeptidase activity GO:0030991//GO:0016021 intraciliary transport particle A//integral component of membrane -- -- Cluster-8309.59866 BP_3 34.79 0.33 5349 270007554 EFA04002.1 2490 6.4e-278 hypothetical protein TcasGA2_TC014151 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 1418 5.4e-155 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13176//PF13414//PF13371//PF13374//PF00515//PF02827//PF13174//PF13181 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0045859//GO:0006469 regulation of protein kinase activity//negative regulation of protein kinase activity GO:0005515//GO:0004862 protein binding//cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex KOG1124 FOG: TPR repeat Cluster-8309.59870 BP_3 13.32 0.48 1616 531444638 AGT57836.1 460 4.8e-43 cytochrome P450 412a1 [Leptinotarsa decemlineata] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 348 1.9e-31 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.59872 BP_3 3.00 0.48 594 189238464 XP_966906.2 153 7.0e-08 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59873 BP_3 6.89 0.31 1356 270009039 EFA05487.1 388 9.0e-35 hypothetical protein TcasGA2_TC015672 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q8CEC6 311 3.1e-27 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Mus musculus GN=Ppwd1 PE=2 SV=2 PF03661//PF06470 Uncharacterised protein family (UPF0121)//SMC proteins Flexible Hinge Domain GO:0051276 chromosome organization GO:0005524//GO:0005515 ATP binding//protein binding GO:0005694//GO:0016021 chromosome//integral component of membrane KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.59875 BP_3 7.68 0.44 1130 795010952 XP_011869921.1 441 5.4e-41 PREDICTED: putative nuclease HARBI1 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q6AZB8 247 6.9e-20 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59876 BP_3 28.15 1.21 1413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59879 BP_3 186.57 9.72 1217 91083443 XP_970123.1 1233 8.4e-133 PREDICTED: tryptophan--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 Q9UGM6 825 7.0e-87 Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens GN=WARS2 PE=1 SV=1 PF00579//PF04904 tRNA synthetases class I (W and Y)//NAB conserved region 1 (NCD1) GO:0045892//GO:0006418 negative regulation of transcription, DNA-templated//tRNA aminoacylation for protein translation GO:0004812//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding GO:0005634 nucleus KOG2713 Mitochondrial tryptophanyl-tRNA synthetase Cluster-8309.59881 BP_3 15.61 1.66 745 478260421 ENN80158.1 510 3.5e-49 hypothetical protein YQE_03421, partial [Dendroctonus ponderosae]>gi|546679917|gb|ERL90299.1| hypothetical protein D910_07650 [Dendroctonus ponderosae] -- -- -- -- -- K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 Q9UGM6 344 2.6e-31 Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens GN=WARS2 PE=1 SV=1 PF00579//PF04904 tRNA synthetases class I (W and Y)//NAB conserved region 1 (NCD1) GO:0006418//GO:0045892 tRNA aminoacylation for protein translation//negative regulation of transcription, DNA-templated GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005634 nucleus KOG2713 Mitochondrial tryptophanyl-tRNA synthetase Cluster-8309.59882 BP_3 26.77 0.44 3221 642928750 XP_008199767.1 870 2.7e-90 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59883 BP_3 1.00 0.38 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59886 BP_3 8.00 1.28 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59887 BP_3 2.23 0.64 460 642930742 XP_008196074.1 517 3.4e-50 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- K04919 KCNK9 potassium channel subfamily K member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04919 O35111 189 1.5e-13 Potassium channel subfamily K member 3 OS=Mus musculus GN=Kcnk3 PE=2 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.59888 BP_3 13.00 0.93 967 -- -- -- -- -- 114306763 AB103600.1 967 0 Homo sapiens gene for HLA-E protein, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59891 BP_3 32.31 0.73 2434 270003866 EFA00314.1 1317 3.0e-142 hypothetical protein TcasGA2_TC003152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5PNP1 382 3.3e-35 Sorting nexin-14 OS=Danio rerio GN=snx14 PE=2 SV=3 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.59893 BP_3 12.00 0.81 1007 -- -- -- -- -- 675324091 CP009079.1 801 0 Verticillium dahliae JR2 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF04145 Ctr copper transporter family GO:0035434//GO:0006825 copper ion transmembrane transport//copper ion transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.59896 BP_3 31.93 0.67 2574 642910817 XP_008193421.1 1434 8.7e-156 PREDICTED: rab11 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 1.0e-26 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.59898 BP_3 2.00 0.78 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01940//PF04647//PF05313//PF06422 Integral membrane protein DUF92//Accessory gene regulator B//Poxvirus P21 membrane protein//CDR ABC transporter GO:0006810//GO:0009372//GO:0009405 transport//quorum sensing//pathogenesis GO:0042626//GO:0008233//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//peptidase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.59899 BP_3 16.10 0.65 1484 156564355 NP_001096056.1 915 7.6e-96 aromatic-L-amino-acid decarboxylase [Tribolium castaneum]>gi|155675828|gb|ABU25222.1| dopa decarboxylase [Tribolium castaneum] 17226785 AF324977.1 125 2.16353e-56 AF324977 Drosophila repleta dopa decarboxylase (Ddc) gene, exon 4 and partial cds K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P48861 829 3.0e-87 Aromatic-L-amino-acid decarboxylase OS=Manduca sexta GN=Ddc PE=2 SV=1 PF00155//PF00282//PF05889 Aminotransferase class I and II//Pyridoxal-dependent decarboxylase conserved domain//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GO:0006558//GO:0006568//GO:0006547//GO:0006520//GO:0009058//GO:0009821//GO:0006570//GO:0042432//GO:0019752 L-phenylalanine metabolic process//tryptophan metabolic process//histidine metabolic process//cellular amino acid metabolic process//biosynthetic process//alkaloid biosynthetic process//tyrosine metabolic process//indole biosynthetic process//carboxylic acid metabolic process GO:0004058//GO:0016831//GO:0016740//GO:0030170 aromatic-L-amino-acid decarboxylase activity//carboxy-lyase activity//transferase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.59902 BP_3 16.19 1.06 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59904 BP_3 45.54 0.33 6976 676434234 XP_009047160.1 752 2.9e-76 hypothetical protein LOTGIDRAFT_212648 [Lottia gigantea]>gi|556113350|gb|ESP02002.1| hypothetical protein LOTGIDRAFT_212648 [Lottia gigantea] -- -- -- -- -- -- -- -- -- Q7RTX9 324 5.0e-28 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF05631 Major Facilitator Superfamily//Sugar-tranasporters, 12 TM GO:0015689//GO:0055085 molybdate ion transport//transmembrane transport GO:0015098 molybdate ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.59906 BP_3 100.89 0.72 7024 642921556 XP_008192422.1 2123 3.0e-235 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60494 922 2.3e-97 Cubilin OS=Homo sapiens GN=CUBN PE=1 SV=5 PF16685 zinc RING finger of MSL2 -- -- GO:0061630 ubiquitin protein ligase activity -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.5991 BP_3 17.25 1.49 851 270016638 EFA13084.1 140 3.2e-06 hypothetical protein TcasGA2_TC011584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF06467 BED zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- -- -- Cluster-8309.59911 BP_3 160.55 5.77 1633 642913250 XP_008201456.1 1520 5.9e-166 PREDICTED: probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum] 585692231 XM_006821346.1 60 3.24318e-20 PREDICTED: Saccoglossus kowalevskii probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase-like (LOC102807371), mRNA K03849 ALG8 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03849 Q9BVK2 1093 7.9e-118 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Homo sapiens GN=ALG8 PE=1 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG2576 Glucosyltransferase - Alg8p Cluster-8309.59915 BP_3 6.00 1.14 545 546673628 ERL85192.1 226 2.2e-16 hypothetical protein D910_02614 [Dendroctonus ponderosae] -- -- -- -- -- K11447 UTX, UTY histone demethylase http://www.genome.jp/dbget-bin/www_bget?ko:K11447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59918 BP_3 12.76 0.36 2017 478263520 ENN81870.1 384 3.9e-34 hypothetical protein YQE_01748, partial [Dendroctonus ponderosae] -- -- -- -- -- K17817 NUDT18, MTH3 8-oxo-dGDP phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17817 -- -- -- -- PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.59921 BP_3 37.43 1.26 1726 752876725 XP_011255775.1 359 2.6e-31 PREDICTED: conserved oligomeric Golgi complex subunit 7-like, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.59923 BP_3 55.29 0.44 6304 642912403 XP_008199493.1 3166 0.0e+00 PREDICTED: liprin-alpha-1 isoform X11 [Tribolium castaneum] 642912398 XM_008201269.1 786 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X9, mRNA -- -- -- -- O75334 1539 5.9e-169 Liprin-alpha-2 OS=Homo sapiens GN=PPFIA2 PE=1 SV=2 PF15724//PF05513//PF02459 TMEM119 family//TraA//Adenoviral DNA terminal protein GO:0000746//GO:0001503//GO:0006260 conjugation//ossification//DNA replication GO:0003677 DNA binding GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.59928 BP_3 14.51 0.43 1911 546679820 ERL90212.1 1181 1.4e-126 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BQA5 701 2.6e-72 Histone H4 transcription factor OS=Homo sapiens GN=HINFP PE=1 SV=2 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.59932 BP_3 24.00 0.54 2417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5994 BP_3 6.37 0.36 1141 189239830 XP_001813387.1 528 4.4e-51 PREDICTED: Meckel syndrome type 1 protein [Tribolium castaneum]>gi|270011929|gb|EFA08377.1| hypothetical protein TcasGA2_TC006020 [Tribolium castaneum] -- -- -- -- -- K19332 MKS1 Meckel syndrome type 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K19332 Q9NXB0 243 2.0e-19 Meckel syndrome type 1 protein OS=Homo sapiens GN=MKS1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59945 BP_3 428.34 6.81 3325 642935230 XP_008199701.1 1350 6.2e-146 PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum]>gi|642935232|ref|XP_008199702.1| PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10572 IPPK inositol-pentakisphosphate 2-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K10572 Q4JL91 355 6.1e-32 Inositol-pentakisphosphate 2-kinase OS=Danio rerio GN=ippk PE=1 SV=3 PF11857//PF06090 Domain of unknown function (DUF3377)//Inositol-pentakisphosphate 2-kinase -- -- GO:0035299//GO:0005524//GO:0004222 inositol pentakisphosphate 2-kinase activity//ATP binding//metalloendopeptidase activity -- -- KOG4749 Inositol polyphosphate kinase Cluster-8309.59948 BP_3 22.85 1.79 906 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59953 BP_3 225.96 7.74 1698 642935459 XP_972294.2 602 1.7e-59 PREDICTED: uncharacterized protein LOC661011 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11298 HMG2L1 high mobility group protein 2-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11298 Q9UGU5 191 3.2e-13 HMG domain-containing protein 4 OS=Homo sapiens GN=HMGXB4 PE=1 SV=2 PF11770 GRB2-binding adapter (GAPT) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.59954 BP_3 123.95 1.43 4458 91083873 XP_974306.1 619 4.8e-61 PREDICTED: uncharacterized protein LOC663153 [Tribolium castaneum]>gi|270007945|gb|EFA04393.1| hypothetical protein TcasGA2_TC014692 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70617 230 2.5e-17 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF04923//PF07469 Ninjurin//Domain of unknown function (DUF1518) GO:0007155//GO:0042246 cell adhesion//tissue regeneration -- -- GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.59959 BP_3 9.00 0.79 842 675366771 KFM59673.1 868 1.2e-90 Retrovirus-related Pol polyprotein from transposon 412, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- O92815 215 2.6e-16 Gag-Pol polyprotein OS=Walleye dermal sarcoma virus GN=gag-pol PE=1 SV=2 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.59961 BP_3 20.43 0.55 2081 675366330 KFM59232.1 1327 1.8e-143 Retrovirus-related Pol polyprotein from transposon 412, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P10394 665 4.3e-68 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF01313 Bacterial export proteins, family 3 GO:0009306 protein secretion -- -- GO:0016020 membrane KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.59967 BP_3 2540.96 39.72 3375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5997 BP_3 8.00 0.36 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59977 BP_3 30.30 0.59 2750 189237630 XP_970913.2 650 7.6e-65 PREDICTED: intersectin-1 [Tribolium castaneum]>gi|270007801|gb|EFA04249.1| hypothetical protein TcasGA2_TC014503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.5998 BP_3 14.60 0.31 2534 642936506 XP_008198464.1 1258 2.2e-135 PREDICTED: LOW QUALITY PROTEIN: alpha-2C adrenergic receptor [Tribolium castaneum] -- -- -- -- -- K04140 ADRA2C adrenergic receptor alpha-2C http://www.genome.jp/dbget-bin/www_bget?ko:K04140 Q90WY6 404 9.6e-38 Alpha-2C adrenergic receptor OS=Danio rerio GN=adra2c PE=3 SV=1 PF01080//PF00001 Presenilin//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0004190 G-protein coupled receptor activity//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.59981 BP_3 6.81 1.39 528 755851224 XP_005175480.2 386 6.0e-35 PREDICTED: E3 ubiquitin-protein ligase parkin [Musca domestica] -- -- -- -- -- K04556 PARK2 parkin http://www.genome.jp/dbget-bin/www_bget?ko:K04556 P22589 142 4.8e-08 Polyubiquitin OS=Phytophthora infestans PE=1 SV=2 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.59988 BP_3 18.00 1.21 1009 642927612 XP_973436.3 253 3.0e-19 PREDICTED: cell growth regulator with RING finger domain protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59991 BP_3 441.35 1.82 12003 546676183 ERL87250.1 7761 0.0e+00 hypothetical protein D910_04647 [Dendroctonus ponderosae] -- -- -- -- -- K19526 VPS13B vacuolar protein sorting-associated protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K19526 Q7Z7G8 952 1.3e-100 Vacuolar protein sorting-associated protein 13B OS=Homo sapiens GN=VPS13B PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.59997 BP_3 3.07 0.46 614 642923214 XP_008193658.1 217 2.7e-15 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59998 BP_3 10.00 0.35 1665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60000 BP_3 350.00 16.47 1316 91084467 XP_970521.1 377 1.6e-33 PREDICTED: uncharacterized protein LOC659096 [Tribolium castaneum]>gi|270008865|gb|EFA05313.1| hypothetical protein TcasGA2_TC015471 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60001 BP_3 3.00 5.66 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60002 BP_3 3.08 0.40 659 546676182 ERL87249.1 252 2.6e-19 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60004 BP_3 1.00 0.70 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60007 BP_3 10.12 0.47 1320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60009 BP_3 28.30 0.62 2488 642911636 XP_008200681.1 676 6.6e-68 PREDICTED: kin of IRRE-like protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60016 BP_3 2.00 0.55 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60018 BP_3 1.00 0.32 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60021 BP_3 1.00 1.25 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60022 BP_3 12.11 0.37 1869 602676209 XP_007443574.1 184 5.6e-11 PREDICTED: zinc finger protein 850-like isoform X1 [Python bivittatus]>gi|602676211|ref|XP_007443575.1| PREDICTED: zinc finger protein 850-like isoform X2 [Python bivittatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8WTV1 171 7.4e-11 THAP domain-containing protein 3 OS=Homo sapiens GN=THAP3 PE=1 SV=1 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.60026 BP_3 356.91 16.38 1342 642929029 XP_973509.2 335 1.2e-28 PREDICTED: SAYSvFN domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NPB0 138 3.6e-07 SAYSvFN domain-containing protein 1 OS=Homo sapiens GN=SAYSD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60029 BP_3 1157.11 10.96 5379 642927353 XP_008195233.1 3614 0.0e+00 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 7-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TE60 682 1.2e-69 A disintegrin and metalloproteinase with thrombospondin motifs 18 OS=Homo sapiens GN=ADAMTS18 PE=1 SV=3 PF15339//PF01421//PF00413//PF01562 Acrosome formation-associated factor//Reprolysin (M12B) family zinc metalloprotease//Matrixin//Reprolysin family propeptide GO:0006508//GO:0007342//GO:0060478//GO:0006897 proteolysis//fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis//endocytosis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012//GO:0005886 extracellular matrix//plasma membrane KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.60033 BP_3 264.00 9.95 1570 642915387 XP_008190595.1 255 2.7e-19 PREDICTED: uncharacterized protein LOC100141615 [Tribolium castaneum]>gi|642915389|ref|XP_008190596.1| PREDICTED: uncharacterized protein LOC100141615 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01292 Prokaryotic cytochrome b561 GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane -- -- Cluster-8309.60040 BP_3 225.24 2.15 5333 270002158 EEZ98605.1 1600 1.0e-174 hypothetical protein TcasGA2_TC001124 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68DX3 288 5.7e-24 FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=3 PF00595//PF13180//PF11427 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Tc3 transposase -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.60044 BP_3 1.00 9.02 246 558761341 AHA90773.1 456 2.1e-43 truncated MHC class I antigen [Homo sapiens] 649152586 KJ905774.1 234 8.12793e-118 Synthetic construct Homo sapiens clone ccsbBroadEn_15444 HLA-C gene, encodes complete protein K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P10321 435 2.4e-42 HLA class I histocompatibility antigen, Cw-7 alpha chain OS=Homo sapiens GN=HLA-C PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60045 BP_3 36.37 1.81 1263 334849656 CCB84409.1 1496 2.8e-163 MHC class I antigen [Homo sapiens] 187783 M24097.1 1106 0 HUMMHCACA Human MHC class I HLA-C-alpha-2 chain and alternative mRNA, complete cds, clones 4 and 10 K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P30508 1496 1.1e-164 HLA class I histocompatibility antigen, Cw-12 alpha chain OS=Homo sapiens GN=HLA-C PE=1 SV=2 PF06623//PF05132//PF00129 MHC_I C-terminus//RNA polymerase III RPC4//Class I Histocompatibility antigen, domains alpha 1 and 2 GO:0006206//GO:0006955//GO:0006144//GO:0006351//GO:0006383//GO:0019882 pyrimidine nucleobase metabolic process//immune response//purine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//antigen processing and presentation GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005666//GO:0005730 DNA-directed RNA polymerase III complex//nucleolus -- -- Cluster-8309.60046 BP_3 6.00 1.00 581 768052080 XP_011546344.1 870 4.9e-91 PREDICTED: major histocompatibility complex, class I, B isoform X7 [Homo sapiens] 768052079 XM_011548042.1 512 0 PREDICTED: Homo sapiens major histocompatibility complex, class I, B (HLA-B), transcript variant X7, mRNA K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P30464 870 2.0e-92 HLA class I histocompatibility antigen, B-15 alpha chain OS=Homo sapiens GN=HLA-B PE=1 SV=2 PF13949//PF00129 ALIX V-shaped domain binding to HIV//Class I Histocompatibility antigen, domains alpha 1 and 2 GO:0006955 immune response GO:0005515 protein binding -- -- -- -- Cluster-8309.60047 BP_3 10.00 1.50 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60052 BP_3 3.00 0.91 451 675706491 XP_009007486.1 688 4.8e-70 PREDICTED: 40S ribosomal protein S15a [Callithrix jacchus] 71772414 NM_001030009.1 451 0 Homo sapiens ribosomal protein S15a (RPS15A), transcript variant 1, mRNA K02957 RP-S15Ae, RPS15A small subunit ribosomal protein S15Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02957 Q76I82 671 1.9e-69 40S ribosomal protein S15a OS=Bos taurus GN=RPS15A PE=2 SV=1 PF00410 Ribosomal protein S8 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1754 40S ribosomal protein S15/S22 Cluster-8309.60054 BP_3 12.66 0.32 2187 478259716 ENN79560.1 1440 1.5e-156 hypothetical protein YQE_04022, partial [Dendroctonus ponderosae] -- -- -- -- -- K19612 PDE12 2',5'-phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19612 Q6AXQ5 786 4.2e-82 2',5'-phosphodiesterase 12 OS=Rattus norvegicus GN=Pde12 PE=2 SV=1 PF01304 Gas vesicles protein GVPc repeated domain GO:0031412 gas vesicle organization -- -- GO:0031411 gas vesicle KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.60058 BP_3 15.42 3.50 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60061 BP_3 23.00 3.82 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60062 BP_3 2320.58 65.94 1988 270007333 EFA03781.1 773 3.0e-79 hypothetical protein TcasGA2_TC013892 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76879 132 2.6e-06 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60063 BP_3 1.00 0.43 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60064 BP_3 8.91 0.92 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60068 BP_3 6.00 1.91 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.60069 BP_3 1.00 1.76 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60074 BP_3 9.55 0.87 818 270016101 EFA12549.1 425 2.8e-39 hypothetical protein TcasGA2_TC001957 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60076 BP_3 15.55 0.72 1339 829834934 XP_012634083.1 869 1.5e-90 PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834939|ref|XP_012634084.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834943|ref|XP_012634086.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834947|ref|XP_012634087.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834951|ref|XP_012634088.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834956|ref|XP_012634089.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834961|ref|XP_012634090.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834966|ref|XP_012634091.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834971|ref|XP_012634092.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834976|ref|XP_012634093.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834981|ref|XP_012634094.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834985|ref|XP_012634095.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834990|ref|XP_012634097.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834999|ref|XP_012634099.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus] -- -- -- -- -- -- -- -- -- Q96DM1 417 1.6e-39 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF01428//PF01609//PF07975 AN1-like Zinc finger//Transposase DDE domain//TFIIH C1-like domain GO:0006313//GO:0006281 transposition, DNA-mediated//DNA repair GO:0008270//GO:0003677//GO:0004803 zinc ion binding//DNA binding//transposase activity -- -- -- -- Cluster-8309.60080 BP_3 70.13 2.50 1645 642920283 XP_008192282.1 1907 7.9e-211 PREDICTED: DNA-directed RNA polymerase III subunit RPC3 [Tribolium castaneum]>gi|270006046|gb|EFA02494.1| hypothetical protein TcasGA2_TC008189 [Tribolium castaneum] -- -- -- -- -- K03023 RPC3, POLR3C DNA-directed RNA polymerase III subunit RPC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03023 Q9BUI4 901 1.5e-95 DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens GN=POLR3C PE=1 SV=1 PF05645 RNA polymerase III subunit RPC82 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG2587 RNA polymerase III (C) subunit Cluster-8309.60081 BP_3 18.00 2.44 647 817061123 XP_012252151.1 203 1.2e-13 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03193 Protein of unknown function, DUF258 -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- -- -- Cluster-8309.60085 BP_3 7.00 0.48 996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60086 BP_3 19.00 0.73 1553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60088 BP_3 54.00 1.91 1656 -- -- -- -- -- 749791977 XR_850236.1 49 4.28592e-14 PREDICTED: Harpegnathos saltator uncharacterized LOC105189064 (LOC105189064), ncRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60092 BP_3 35.43 2.09 1108 -- -- -- -- -- 768311757 CP010985.1 493 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- PF00190//PF03229 Cupin//Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process GO:0045735 nutrient reservoir activity -- -- -- -- Cluster-8309.60094 BP_3 78.94 0.63 6298 189239162 XP_972375.2 4852 0.0e+00 PREDICTED: NADPH oxidase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96PH1 1097 1.1e-117 NADPH oxidase 5 OS=Homo sapiens GN=NOX5 PE=1 SV=1 PF08030//PF00036//PF08022//PF13202//PF13405//PF13833//PF13499//PF00175 Ferric reductase NAD binding domain//EF hand//FAD-binding domain//EF hand//EF-hand domain//EF-hand domain pair//EF-hand domain pair//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0005509 oxidoreductase activity//calcium ion binding -- -- KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.60096 BP_3 1016.24 16.07 3340 642929775 XP_008195969.1 1222 4.3e-131 PREDICTED: uncharacterized protein LOC664468 isoform X2 [Tribolium castaneum] 642929774 XM_008197747.1 105 6.47048e-45 PREDICTED: Tribolium castaneum uncharacterized LOC664468 (LOC664468), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60098 BP_3 9.00 0.58 1041 157690672 CAL69063.1 407 4.3e-37 TPA: putative 60S ribosomal protein L13 [Spadella cephaloptera] 768311754 CP010982.1 753 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 O59931 404 4.0e-38 60S ribosomal protein L13 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RPL13 PE=3 SV=1 PF01294 Ribosomal protein L13e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3295 60S Ribosomal protein L13 Cluster-8309.60101 BP_3 19.79 0.41 2614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00220 Neurohypophysial hormones, N-terminal Domain GO:0007218 neuropeptide signaling pathway GO:0005185 neurohypophyseal hormone activity GO:0005576 extracellular region -- -- Cluster-8309.60112 BP_3 48.71 0.66 3843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60113 BP_3 139.44 1.34 5298 642922778 XP_008193321.1 2493 2.9e-278 PREDICTED: transmembrane and TPR repeat-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 1418 5.3e-155 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13176//PF13414//PF13174//PF00515//PF13374//PF13181//PF02827 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG1124 FOG: TPR repeat Cluster-8309.60116 BP_3 88.71 0.41 10640 270007354 EFA03802.1 5799 0.0e+00 hypothetical protein TcasGA2_TC013915 [Tribolium castaneum] 642917043 XM_008192874.1 352 0 PREDICTED: Tribolium castaneum diacylglycerol kinase eta-like (LOC103312380), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 B4K6T8 2049 7.2e-228 Diacylglycerol kinase eta OS=Drosophila mojavensis GN=GI24133 PE=3 SV=1 PF02017//PF07647//PF00536//PF00130//PF00609//PF07649//PF16866//PF02198//PF00781 CIDE-N domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//C1-like domain//PHD-finger//Sterile alpha motif (SAM)/Pointed domain//Diacylglycerol kinase catalytic domain GO:0007205//GO:0009395//GO:0006915//GO:0046486//GO:0055114//GO:0035556 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//apoptotic process//glycerolipid metabolic process//oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0004143//GO:0047134//GO:0016301//GO:0043565 protein binding//diacylglycerol kinase activity//protein-disulfide reductase activity//kinase activity//sequence-specific DNA binding GO:0005634//GO:0005622 nucleus//intracellular KOG1170 Diacylglycerol kinase Cluster-8309.60123 BP_3 145.00 3.28 2423 642934709 XP_008197779.1 945 4.1e-99 PREDICTED: condensin complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K06676 BRRN1, BRN1, CAPH condensin complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06676 O13067 318 8.7e-28 Condensin complex subunit 2 OS=Xenopus laevis GN=ncaph PE=1 SV=1 PF15427//PF05786 S100P-binding protein//Condensin complex subunit 2 GO:0007076 mitotic chromosome condensation GO:0048306 calcium-dependent protein binding GO:0000796 condensin complex KOG2328 Chromosome condensation complex Condensin, subunit H Cluster-8309.60126 BP_3 24.33 0.44 2948 270016446 EFA12892.1 1169 5.4e-125 hypothetical protein TcasGA2_TC004406 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q7Z2H8 613 6.5e-62 Proton-coupled amino acid transporter 1 OS=Homo sapiens GN=SLC36A1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.60127 BP_3 24.40 0.38 3359 332373870 AEE62076.1 299 4.7e-24 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V7S5 174 6.0e-11 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF09594 Major Facilitator Superfamily//Protein of unknown function (DUF2029) GO:0055085 transmembrane transport GO:0016758 transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane -- -- Cluster-8309.60129 BP_3 76.40 0.62 6236 478251376 ENN71842.1 192 2.2e-11 hypothetical protein YQE_11460, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6013 BP_3 17.00 0.58 1695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60131 BP_3 1.00 2.02 296 4502981 NP_001852.1 324 5.1e-28 cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [Homo sapiens]>gi|353681773|ref|NP_001238844.1| cytochrome c oxidase subunit 4 isoform 1, mitochondrial [Pan troglodytes]>gi|397500380|ref|XP_003820894.1| PREDICTED: cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [Pan paniscus]>gi|530423589|ref|XP_005255855.1| PREDICTED: cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [Homo sapiens]>gi|117086|sp|P13073.1|COX41_HUMAN RecName: Full=Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide IV; AltName: Full=Cytochrome c oxidase subunit IV isoform 1; Short=COX IV-1; Flags: Precursor>gi|180933|gb|AAA99312.1| cytochrome c oxidase subunit IV precursor [Homo sapiens]>gi|180935|gb|AAA52059.1| cytochrome c oxidase subunit IV (COX4) [Homo sapiens]>gi|517252|emb|CAA38573.1| cytochrome-c oxidase subunit IV [Homo sapiens]>gi|1913896|gb|AAB51058.1| cytochrome c oxidase subunit IV [Homo sapiens]>gi|2738492|gb|AAB94819.1| cytochrome c oxidase subunit IV precursor [Homo sapiens]>gi|4092857|gb|AAC99578.1| cytochrome c oxidase subunit IV precursor [Homo sapiens]>gi|14250514|gb|AAH08704.1| Cytochrome c oxidase subunit IV isoform 1 [Homo sapiens]>gi|18203795|gb|AAH21236.1| Cytochrome c oxidase subunit IV isoform 1 [Homo sapiens]>gi|54696512|gb|AAV38628.1| cytochrome c oxidase subunit IV isoform 1 [Homo sapiens]>gi|61357719|gb|AAX41434.1| cytochrome c oxidase subunit IV isoform 1 [synthetic construct]>gi|119615843|gb|EAW95437.1| cytochrome c oxidase subunit IV isoform 1, isoform CRA_b [Homo sapiens]>gi|119615844|gb|EAW95438.1| cytochrome c oxidase subunit IV isoform 1, isoform CRA_b [Homo sapiens]>gi|123992973|gb|ABM84088.1| cytochrome c oxidase subunit IV isoform 1 [synthetic construct]>gi|123999899|gb|ABM87458.1| cytochrome c oxidase subunit IV isoform 1 [synthetic construct]>gi|189053167|dbj|BAG34789.1| unnamed protein product [Homo sapiens]>gi|649099306|gb|AIC48546.1| COX4I1, partial [synthetic construct]>gi|225734|prf||1312293A cytochrome c oxidase IV 767989402 XM_011522871.1 296 3.43515e-152 PREDICTED: Homo sapiens cytochrome c oxidase subunit IV isoform 1 (COX4I1), transcript variant X1, mRNA K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P13073 324 2.1e-29 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens GN=COX4I1 PE=1 SV=1 PF02936 Cytochrome c oxidase subunit IV GO:0022904//GO:0006123//GO:0044281//GO:0007584//GO:0015992 respiratory electron transport chain//mitochondrial electron transport, cytochrome c to oxygen//small molecule metabolic process//response to nutrient//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005634//GO:0005743//GO:0045277 nucleus//mitochondrial inner membrane//respiratory chain complex IV -- -- Cluster-8309.60136 BP_3 80.00 4.74 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60142 BP_3 102.14 33.53 438 270009891 EFA06339.1 188 4.5e-12 hypothetical protein TcasGA2_TC009212 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60143 BP_3 209.83 42.25 531 91086125 XP_968458.1 316 7.8e-27 PREDICTED: EGF-like domain-containing protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09570 SinI restriction endonuclease GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0009036//GO:0003677 Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.60147 BP_3 45.00 2.46 1175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60150 BP_3 130.93 1.63 4154 642911951 XP_008199035.1 2062 2.1e-228 PREDICTED: GPI ethanolamine phosphate transferase 1 isoform X1 [Tribolium castaneum] 815881985 XM_001241521.2 35 6.59733e-06 Coccidioides immitis RS GPI ethanolamine phosphate transferase 1 mRNA K05285 PIGN phosphatidylinositol glycan, class N http://www.genome.jp/dbget-bin/www_bget?ko:K05285 Q9R1S3 1386 2.1e-151 GPI ethanolamine phosphate transferase 1 OS=Mus musculus GN=Pign PE=2 SV=2 PF02563//PF01676//PF01663//PF00884//PF04987 Polysaccharide biosynthesis/export protein//Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase//Phosphatidylinositolglycan class N (PIG-N) GO:0015774//GO:0008152//GO:0006506 polysaccharide transport//metabolic process//GPI anchor biosynthetic process GO:0015159//GO:0016740//GO:0003824//GO:0046872//GO:0008484 polysaccharide transmembrane transporter activity//transferase activity//catalytic activity//metal ion binding//sulfuric ester hydrolase activity GO:0005789//GO:0016020 endoplasmic reticulum membrane//membrane KOG2124 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.60154 BP_3 2.00 0.53 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60157 BP_3 8.00 0.85 746 546677206 ERL88085.1 166 2.7e-09 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60167 BP_3 12.69 0.93 951 641650829 XP_008189887.1 139 4.7e-06 PREDICTED: uncharacterized protein LOC100575276 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60169 BP_3 5.31 0.43 888 641650829 XP_008189887.1 139 4.4e-06 PREDICTED: uncharacterized protein LOC100575276 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6017 BP_3 13.00 0.89 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60170 BP_3 47.27 1.38 1942 478251097 ENN71573.1 242 1.1e-17 hypothetical protein YQE_11673, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01771 Herpesvirus alkaline exonuclease -- -- GO:0003677//GO:0004527 DNA binding//exonuclease activity -- -- -- -- Cluster-8309.60172 BP_3 116.24 0.96 6111 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60176 BP_3 44.69 0.82 2933 642935230 XP_008199701.1 743 1.3e-75 PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum]>gi|642935232|ref|XP_008199702.1| PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4JL91 222 1.4e-16 Inositol-pentakisphosphate 2-kinase OS=Danio rerio GN=ippk PE=1 SV=3 PF06090//PF11857 Inositol-pentakisphosphate 2-kinase//Domain of unknown function (DUF3377) -- -- GO:0035299//GO:0005524//GO:0004222 inositol pentakisphosphate 2-kinase activity//ATP binding//metalloendopeptidase activity -- -- KOG4749 Inositol polyphosphate kinase Cluster-8309.60182 BP_3 103.87 1.71 3212 91085531 XP_972280.1 1546 1.1e-168 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q8VC97 1256 2.0e-136 Beta-ureidopropionase OS=Mus musculus GN=Upb1 PE=2 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG2648 Diphthamide biosynthesis protein Cluster-8309.60183 BP_3 350.00 6.92 2730 642929332 XP_973791.2 1858 6.3e-205 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum]>gi|270010511|gb|EFA06959.1| hypothetical protein TcasGA2_TC009917 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 372 5.3e-34 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.60186 BP_3 17.09 0.43 2199 270002371 EEZ98818.1 1671 2.5e-183 hypothetical protein TcasGA2_TC004424 [Tribolium castaneum] -- -- -- -- -- K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 P10040 1004 2.2e-107 Protein crumbs OS=Drosophila melanogaster GN=crb PE=1 SV=3 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.60188 BP_3 2893.34 141.40 1278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04111//PF03153//PF02970 Autophagy protein Apg6//Transcription factor IIA, alpha/beta subunit//Tubulin binding cofactor A GO:0007021//GO:0006367//GO:0006914 tubulin complex assembly//transcription initiation from RNA polymerase II promoter//autophagy GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0005672//GO:0045298 transcription factor TFIIA complex//tubulin complex -- -- Cluster-8309.60189 BP_3 2.00 0.62 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6019 BP_3 3.00 0.54 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60190 BP_3 2.00 0.52 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60192 BP_3 26.77 1.32 1267 749784255 XP_011146009.1 421 1.2e-38 PREDICTED: uncharacterized protein LOC105187106, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.60194 BP_3 206.69 6.11 1922 546676004 ERL87099.1 1494 7.2e-163 hypothetical protein D910_04499 [Dendroctonus ponderosae] -- -- -- -- -- K15027 EIF2D translation initiation factor 2D http://www.genome.jp/dbget-bin/www_bget?ko:K15027 Q58CR3 698 5.9e-72 Eukaryotic translation initiation factor 2D OS=Bos taurus GN=EIF2D PE=2 SV=1 PF01253//PF01472//PF02201 Translation initiation factor SUI1//PUA domain//SWIB/MDM2 domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743//GO:0005515 RNA binding//translation initiation factor activity//protein binding GO:0005840 ribosome KOG2522 Filamentous baseplate protein Ligatin, contains PUA domain Cluster-8309.60195 BP_3 123.31 3.52 1980 546676004 ERL87099.1 1404 2.0e-152 hypothetical protein D910_04499 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q58CR3 625 1.8e-63 Eukaryotic translation initiation factor 2D OS=Bos taurus GN=EIF2D PE=2 SV=1 PF01253//PF02201//PF01472 Translation initiation factor SUI1//SWIB/MDM2 domain//PUA domain GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0005515//GO:0003723//GO:0003743 protein binding//RNA binding//translation initiation factor activity GO:0005840 ribosome KOG2522 Filamentous baseplate protein Ligatin, contains PUA domain Cluster-8309.602 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60202 BP_3 14.06 0.34 2296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06180 Cobalt chelatase (CbiK) GO:0019251//GO:0006783 anaerobic cobalamin biosynthetic process//heme biosynthetic process GO:0016852 sirohydrochlorin cobaltochelatase activity -- -- -- -- Cluster-8309.60203 BP_3 678.25 27.26 1491 642935437 XP_971822.3 1130 9.0e-121 PREDICTED: pancreatic triacylglycerol lipase [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 P54318 420 7.9e-40 Pancreatic lipase-related protein 2 OS=Rattus norvegicus GN=Pnliprp2 PE=1 SV=1 PF02230//PF00975 Phospholipase/Carboxylesterase//Thioesterase domain GO:0009058 biosynthetic process GO:0016787//GO:0016788 hydrolase activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.60205 BP_3 15.91 0.36 2418 642919387 XP_008191852.1 1900 7.6e-210 PREDICTED: synaptotagmin-5 isoform X3 [Tribolium castaneum] 768449804 XM_011568704.1 71 3.71238e-26 PREDICTED: Plutella xylostella synaptotagmin-5-like (LOC105396697), partial mRNA -- -- -- -- Q9R0N8 502 4.0e-49 Synaptotagmin-6 OS=Mus musculus GN=Syt6 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.60209 BP_3 22.28 0.37 3178 189238110 XP_001814014.1 1310 2.6e-141 PREDICTED: PHD finger protein 12 [Tribolium castaneum]>gi|270008739|gb|EFA05187.1| hypothetical protein TcasGA2_TC015317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96QT6 401 2.7e-37 PHD finger protein 12 OS=Homo sapiens GN=PHF12 PE=1 SV=2 PF00130//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG4299 PHD Zn-finger protein Cluster-8309.60212 BP_3 10.71 0.81 933 189236986 XP_001810629.1 285 5.4e-23 PREDICTED: general transcription factor 3C polypeptide 5 [Tribolium castaneum]>gi|270006625|gb|EFA03073.1| hypothetical protein TcasGA2_TC010945 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5Q8 129 2.7e-06 General transcription factor 3C polypeptide 5 OS=Homo sapiens GN=GTF3C5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2473 RNA polymerase III transcription factor (TF)IIIC subunit Cluster-8309.60217 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6022 BP_3 7.00 0.39 1161 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60220 BP_3 59.72 0.50 6010 642911720 XP_971006.2 1110 7.6e-118 PREDICTED: polycomb group RING finger protein 3 [Tribolium castaneum] 642911719 XM_965913.3 273 4.75857e-138 PREDICTED: Tribolium castaneum polycomb group RING finger protein 3 (LOC659626), mRNA K11488 PCGF3 polycomb group RING finger protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11488 Q2KJ29 802 1.6e-83 Polycomb group RING finger protein 3 OS=Bos taurus GN=PCGF3 PE=2 SV=1 PF11789//PF03271//PF14634//PF12678//PF06467//PF00097//PF16685//PF13639 Zinc-finger of the MIZ type in Nse subunit//EB1-like C-terminal motif//zinc-RING finger domain//RING-H2 zinc finger//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C3HC4 type (RING finger)//zinc RING finger of MSL2//Ring finger domain -- -- GO:0061630//GO:0046872//GO:0005515//GO:0008270//GO:0008017 ubiquitin protein ligase activity//metal ion binding//protein binding//zinc ion binding//microtubule binding GO:0045298 tubulin complex KOG2660 Locus-specific chromosome binding proteins Cluster-8309.60221 BP_3 73.03 2.72 1587 91085531 XP_972280.1 985 6.2e-104 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q5RBM6 857 1.8e-90 Beta-ureidopropionase OS=Pongo abelii GN=UPB1 PE=2 SV=1 PF00795//PF01819 Carbon-nitrogen hydrolase//Levivirus coat protein GO:0006807 nitrogen compound metabolic process GO:0005198//GO:0016810 structural molecule activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0019028 viral capsid KOG0808 Carbon-nitrogen hydrolase Cluster-8309.60222 BP_3 185.72 4.13 2461 642913398 XP_008200993.1 287 8.4e-23 PREDICTED: fruitless isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IN81 267 7.2e-22 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60223 BP_3 182.91 1.40 6582 642931365 XP_008196548.1 7127 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X4 [Tribolium castaneum] 8248420 AF247761.1 302 3.94433e-154 AF247761 Drosophila melanogaster kinesin superfamily member DUnc104 mRNA, complete cds K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5818 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF07353//PF10390//PF05014//PF05171//PF00498//PF00225//PF00959 Uroplakin II//RNA polymerase II elongation factor ELL//Nucleoside 2-deoxyribosyltransferase//Haemin-degrading HemS.ChuX domain//FHA domain//Kinesin motor domain//Phage lysozyme GO:0009159//GO:0009253//GO:0007018//GO:0006826//GO:0005975//GO:0007017//GO:0061024//GO:0006368//GO:0016998//GO:0006206 deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process//microtubule-based movement//iron ion transport//carbohydrate metabolic process//microtubule-based process//membrane organization//transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process//pyrimidine nucleobase metabolic process GO:0050144//GO:0005524//GO:0005515//GO:0003777//GO:0003796//GO:0070694//GO:0008017 nucleoside deoxyribosyltransferase activity//ATP binding//protein binding//microtubule motor activity//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//microtubule binding GO:0045298//GO:0005874//GO:0030176//GO:0008023 tubulin complex//microtubule//integral component of endoplasmic reticulum membrane//transcription elongation factor complex KOG0245 Kinesin-like protein Cluster-8309.60226 BP_3 38.11 1.21 1812 91087599 XP_972227.1 624 5.2e-62 PREDICTED: uncharacterized protein LOC660940 [Tribolium castaneum]>gi|270010702|gb|EFA07150.1| hypothetical protein TcasGA2_TC010144 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60229 BP_3 33.50 0.86 2161 642913194 XP_008201431.1 1098 6.7e-117 PREDICTED: E3 ubiquitin-protein ligase SHPRH isoform X2 [Tribolium castaneum] -- -- -- -- -- K15710 SHPRH E3 ubiquitin-protein ligase SHPRH http://www.genome.jp/dbget-bin/www_bget?ko:K15710 Q149N8 618 1.3e-62 E3 ubiquitin-protein ligase SHPRH OS=Homo sapiens GN=SHPRH PE=1 SV=2 PF13639//PF00097//PF02891//PF12678//PF12861//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG0298 DEAD box-containing helicase-like transcription factor/DNA repair protein Cluster-8309.6023 BP_3 2.00 0.44 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60230 BP_3 10.48 0.45 1420 642916843 XP_008199526.1 264 2.2e-20 PREDICTED: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [Tribolium castaneum]>gi|270003073|gb|EEZ99520.1| hypothetical protein TcasGA2_TC000101 [Tribolium castaneum] -- -- -- -- -- K01482 DDAH, ddaH dimethylargininase http://www.genome.jp/dbget-bin/www_bget?ko:K01482 P56965 135 8.4e-07 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Bos taurus GN=DDAH1 PE=1 SV=3 -- -- GO:0006807 nitrogen compound metabolic process GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0005737 cytoplasm -- -- Cluster-8309.60237 BP_3 4.00 0.70 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60243 BP_3 225.47 5.13 2409 91095179 XP_971501.1 1041 3.0e-110 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43663 554 3.7e-55 Protein regulator of cytokinesis 1 OS=Homo sapiens GN=PRC1 PE=1 SV=2 PF03999 Microtubule associated protein (MAP65/ASE1 family) GO:0000910//GO:0000226 cytokinesis//microtubule cytoskeleton organization GO:0008017 microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-8309.60246 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60247 BP_3 409.16 9.10 2458 91095179 XP_971501.1 1008 2.1e-106 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43663 554 3.8e-55 Protein regulator of cytokinesis 1 OS=Homo sapiens GN=PRC1 PE=1 SV=2 PF03999 Microtubule associated protein (MAP65/ASE1 family) GO:0000910//GO:0000226 cytokinesis//microtubule cytoskeleton organization GO:0008017 microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-8309.60248 BP_3 2.00 0.72 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60249 BP_3 6.98 0.32 1345 642927192 XP_008195174.1 335 1.2e-28 PREDICTED: centrosomal protein of 104 kDa [Tribolium castaneum] -- -- -- -- -- K16458 CEP104 centrosomal protein CEP104 http://www.genome.jp/dbget-bin/www_bget?ko:K16458 Q80V31 192 2.0e-13 Centrosomal protein of 104 kDa OS=Mus musculus GN=Cep104 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60251 BP_3 1.00 1.43 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60254 BP_3 13.65 1.12 878 861587820 KMQ82561.1 367 1.6e-32 transposable element tc3 transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404//PF04790 AsnC-type helix-turn-helix domain//Sarcoglycan complex subunit protein GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.60256 BP_3 7.55 0.77 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60259 BP_3 45.23 2.43 1190 91077632 XP_974008.1 385 1.8e-34 PREDICTED: venom acid phosphatase Acph-1 [Tribolium castaneum]>gi|270002186|gb|EEZ98633.1| hypothetical protein TcasGA2_TC001160 [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q5BLY5 239 6.1e-19 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.6026 BP_3 21.00 1.89 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60267 BP_3 2.00 1.35 359 185972 AAA58928.1 528 1.4e-51 immunoglobulin kappa chain, partial [Homo sapiens]>gi|185974|gb|AAA58929.1| immunoglobulin kappa chain, partial [Homo sapiens]>gi|185976|gb|AAB46375.1| immunoglobulin kappa chain, partial [Homo sapiens] 3928324 Z69024.1 327 2.49117e-169 H.sapiens mRNA for immunoglobulin kappa light chain VJ region (ID POM629) -- -- -- -- P04207 515 1.8e-51 Ig kappa chain V-III region CLL OS=Homo sapiens PE=4 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60268 BP_3 24.37 0.31 4076 642934658 XP_008197755.1 4026 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 8.25491e-15 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 527 8.5e-52 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60271 BP_3 3.00 1.26 405 332376164 AEE63222.1 168 8.7e-10 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60274 BP_3 100.33 1.42 3704 91093355 XP_969078.1 1092 5.7e-116 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IWG1 433 6.1e-41 WD repeat-containing protein 63 OS=Homo sapiens GN=WDR63 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.60275 BP_3 4.00 3.08 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60276 BP_3 121.12 2.97 2259 642915245 XP_008190539.1 1070 1.2e-113 PREDICTED: ZZ-type zinc finger-containing protein 3 [Tribolium castaneum]>gi|270003948|gb|EFA00396.1| hypothetical protein TcasGA2_TC003246 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IYH5 407 3.9e-38 ZZ-type zinc finger-containing protein 3 OS=Homo sapiens GN=ZZZ3 PE=1 SV=1 PF00569 Zinc finger, ZZ type -- -- GO:0008270//GO:0005488 zinc ion binding//binding -- -- -- -- Cluster-8309.60279 BP_3 8.70 1.61 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60282 BP_3 37.84 1.15 1880 270005507 EFA01955.1 585 1.8e-57 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P20432 513 1.6e-50 Glutathione S-transferase 1-1 OS=Drosophila melanogaster GN=GstD1 PE=1 SV=1 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6029 BP_3 474.37 26.64 1150 795014106 XP_011883766.1 739 1.5e-75 PREDICTED: uncharacterized protein LOC105570924 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05408 Foot-and-mouth virus L-proteinase GO:0019082//GO:0016032//GO:0006508 viral protein processing//viral process//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.60292 BP_3 2.00 21.76 241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60297 BP_3 50.43 0.68 3857 642926332 XP_968832.2 2900 0.0e+00 PREDICTED: RING finger protein 207 isoform X2 [Tribolium castaneum] 642926333 XM_008196659.1 210 3.19812e-103 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 670 2.1e-68 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF06005//PF00643//PF14634//PF00097//PF04513//PF04673//PF13639//PF16685//PF04728 Protein of unknown function (DUF904)//B-box zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Baculovirus polyhedron envelope protein, PEP, C terminus//Polyketide synthesis cyclase//Ring finger domain//zinc RING finger of MSL2//Lipoprotein leucine-zipper GO:0000917//GO:0043093//GO:0030639 barrier septum assembly//FtsZ-dependent cytokinesis//polyketide biosynthetic process GO:0008270//GO:0046872//GO:0061630//GO:0005198//GO:0005515 zinc ion binding//metal ion binding//ubiquitin protein ligase activity//structural molecule activity//protein binding GO:0005622//GO:0005737//GO:0019028//GO:0019867//GO:0019031 intracellular//cytoplasm//viral capsid//outer membrane//viral envelope -- -- Cluster-8309.60302 BP_3 17.00 0.32 2861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60304 BP_3 29.00 1.73 1098 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60305 BP_3 104.88 0.90 5929 642937342 XP_008198796.1 1602 6.7e-175 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b [Tribolium castaneum] -- -- -- -- -- K01128 SMPDL3 sphingomyelin phosphodiesterase acid-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K01128 P58242 552 1.6e-54 Acid sphingomyelinase-like phosphodiesterase 3b OS=Mus musculus GN=Smpdl3b PE=1 SV=1 PF00119 ATP synthase A chain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.60307 BP_3 24.09 0.80 1749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60312 BP_3 97.74 3.46 1652 546679672 ERL90099.1 1785 1.1e-196 hypothetical protein D910_07453 [Dendroctonus ponderosae] -- -- -- -- -- K12367 DOCK2 dedicator of cytokinesis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12367 Q8C3J5 1015 8.9e-109 Dedicator of cytokinesis protein 2 OS=Mus musculus GN=Dock2 PE=1 SV=3 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60314 BP_3 36.27 1.74 1297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60316 BP_3 88.15 0.52 8479 642934007 XP_008197600.1 1043 6.3e-110 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] 584600633 EU595402.2 44 1.34251e-10 Drosophila virilis kl-2 1-beta dynein heavy chain mRNA, partial cds K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P0C6F1 735 1.3e-75 Dynein heavy chain 2, axonemal OS=Mus musculus GN=Dnah2 PE=2 SV=1 PF03028//PF01467//PF02993//PF00008 Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like//Minor capsid protein VI//EGF-like domain GO:0007018//GO:0009058//GO:0007017 microtubule-based movement//biosynthetic process//microtubule-based process GO:0005515//GO:0003777//GO:0003824 protein binding//microtubule motor activity//catalytic activity GO:0005874//GO:0019028//GO:0030286 microtubule//viral capsid//dynein complex KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.60317 BP_3 207.73 1.98 5360 270013679 EFA10127.1 1321 2.3e-142 hypothetical protein TcasGA2_TC012307 [Tribolium castaneum] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P0C6F1 659 5.5e-67 Dynein heavy chain 2, axonemal OS=Mus musculus GN=Dnah2 PE=2 SV=1 PF00008//PF03028//PF01467 EGF-like domain//Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like GO:0007018//GO:0007017//GO:0009058 microtubule-based movement//microtubule-based process//biosynthetic process GO:0003824//GO:0005515//GO:0003777 catalytic activity//protein binding//microtubule motor activity GO:0030286//GO:0005874 dynein complex//microtubule KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.60321 BP_3 28.00 1.30 1331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60330 BP_3 2.00 0.35 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60331 BP_3 90.33 1.42 3359 270008685 EFA05133.1 1253 1.1e-134 hypothetical protein TcasGA2_TC015248 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09258//PF01699//PF00822 Glycosyl transferase family 64 domain//Sodium/calcium exchanger protein//PMP-22/EMP/MP20/Claudin family GO:0015012//GO:0055085//GO:0006024 heparan sulfate proteoglycan biosynthetic process//transmembrane transport//glycosaminoglycan biosynthetic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.60333 BP_3 142.85 3.23 2424 270002290 EEZ98737.1 2444 6.3e-273 hypothetical protein TcasGA2_TC001292 [Tribolium castaneum] -- -- -- -- -- K03352 APC5 anaphase-promoting complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03352 Q9UJX4 838 4.4e-88 Anaphase-promoting complex subunit 5 OS=Homo sapiens GN=ANAPC5 PE=1 SV=2 PF07721//PF00515//PF13374//PF13181//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0042802//GO:0005515 identical protein binding//protein binding -- -- KOG4322 Anaphase-promoting complex (APC), subunit 5 Cluster-8309.60337 BP_3 2.63 0.34 660 270001177 EEZ97624.1 284 5.0e-23 hypothetical protein TcasGA2_TC016072 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60352 BP_3 9.78 0.32 1742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60355 BP_3 13.62 0.33 2290 12958095 AAK07485.1 425 7.8e-39 gag-pol polyprotein [Clonorchis sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60358 BP_3 12.39 0.32 2139 861624759 KMQ88359.1 1962 4.3e-217 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P04323 674 4.0e-69 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.60361 BP_3 1.00 0.61 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60362 BP_3 1.00 0.35 430 91076618 XP_969384.1 276 2.7e-22 PREDICTED: trypsin II-P29 [Tribolium castaneum]>gi|270002914|gb|EEZ99361.1| serine protease H59 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.60366 BP_3 10.00 0.33 1761 645020639 XP_008207241.1 217 7.9e-15 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60368 BP_3 40.19 0.96 2311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03391 Nepovirus coat protein, central domain -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.60370 BP_3 20.30 1.28 1057 642920067 XP_008192192.1 545 4.4e-53 PREDICTED: nuclear RNA export factor 2-like [Tribolium castaneum]>gi|270005996|gb|EFA02444.1| hypothetical protein TcasGA2_TC008131 [Tribolium castaneum] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q9UBU9 236 1.2e-18 Nuclear RNA export factor 1 OS=Homo sapiens GN=NXF1 PE=1 SV=1 PF03943 TAP C-terminal domain GO:0051028 mRNA transport -- -- GO:0005634 nucleus -- -- Cluster-8309.60377 BP_3 10.50 0.34 1786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6038 BP_3 115.62 4.27 1597 821123351 XP_012384018.1 412 1.7e-37 PREDICTED: zinc finger protein 420-like [Dasypus novemcinctus] -- -- -- -- -- -- -- -- -- P18753 385 9.7e-36 Oocyte zinc finger protein XlCOF8.4 (Fragment) OS=Xenopus laevis PE=2 SV=1 PF00096//PF13465//PF00130//PF02892//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type GO:0035556 intracellular signal transduction GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.60384 BP_3 13.08 0.34 2169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00895//PF04083 ATP synthase protein 8//Partial alpha/beta-hydrolase lipase region GO:0015986//GO:0006629//GO:0015992 ATP synthesis coupled proton transport//lipid metabolic process//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.60386 BP_3 205.33 7.01 1704 91085721 XP_973270.1 1592 2.8e-174 PREDICTED: UPF0586 protein CG11596 [Tribolium castaneum]>gi|270010015|gb|EFA06463.1| hypothetical protein TcasGA2_TC009347 [Tribolium castaneum] 572265872 XM_006611000.1 68 1.20969e-24 PREDICTED: Apis dorsata UPF0586 protein C9orf41-like (LOC102671931), transcript variant X2, mRNA -- -- -- -- Q9I7X6 884 1.4e-93 Carnosine N-methyltransferase OS=Drosophila melanogaster GN=CG11596 PE=1 SV=1 PF08241 Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG2798 Putative trehalase Cluster-8309.6039 BP_3 56.00 0.55 5205 768427282 XP_011554725.1 147 3.0e-06 PREDICTED: zinc finger protein 260-like isoform X2 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363//PF00096//PF13465 FYVE zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.60392 BP_3 84.00 1.10 3985 270014457 EFA10905.1 2534 3.8e-283 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 820 8.8e-86 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF01176//PF01580//PF16588//PF00098 Translation initiation factor 1A / IF-1//FtsK/SpoIIIE family//C2H2 zinc-finger//Zinc knuckle GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003676//GO:0000166//GO:0008270//GO:0003743//GO:0003677//GO:0005524//GO:0003723 nucleic acid binding//nucleotide binding//zinc ion binding//translation initiation factor activity//DNA binding//ATP binding//RNA binding GO:0005840 ribosome -- -- Cluster-8309.60395 BP_3 105.00 89.42 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60396 BP_3 16.00 1.24 915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60398 BP_3 28.89 1.61 1156 478256643 ENN76825.1 205 1.3e-13 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N3L3 145 4.7e-08 Beta-taxilin OS=Homo sapiens GN=TXLNB PE=1 SV=3 PF00548//PF09728 3C cysteine protease (picornain 3C)//Myosin-like coiled-coil protein GO:0006508 proteolysis GO:0019905//GO:0004197 syntaxin binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.60399 BP_3 158.81 0.73 10756 270011728 EFA08176.1 1141 3.5e-121 hypothetical protein TcasGA2_TC005803 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TN88 337 2.4e-29 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF05393//PF00520//PF06160 Human adenovirus early E3A glycoprotein//Ion transport protein//Septation ring formation regulator, EzrA GO:0055085//GO:0000921//GO:0006811 transmembrane transport//septin ring assembly//ion transport GO:0005216 ion channel activity GO:0016021//GO:0016020//GO:0005940 integral component of membrane//membrane//septin ring KOG3599 Ca2+-modulated nonselective cation channel polycystin Cluster-8309.604 BP_3 16.00 1.02 1047 270006419 EFA02867.1 211 2.3e-14 odorant receptor 128 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VT08 125 9.0e-06 Odorant receptor 67a OS=Drosophila melanogaster GN=Or67a PE=1 SV=2 PF02949//PF08395 7tm Odorant receptor//7tm Chemosensory receptor GO:0007187//GO:0050909//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of taste//sensory perception of smell GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.60403 BP_3 25.00 1.47 1113 166919225 ABZ04010.1 605 5.1e-60 serine protease 2 [Costelytra zealandica] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P35036 523 6.7e-52 Trypsin-2 OS=Anopheles gambiae GN=TRYP2 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.60406 BP_3 11.63 0.60 1225 642915469 XP_008190632.1 434 3.8e-40 PREDICTED: TBC1 domain family member 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60413 BP_3 1.00 1.62 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6042 BP_3 92.22 1.20 3988 189236708 XP_974222.2 1766 4.3e-194 PREDICTED: uncharacterized protein LOC663068 [Tribolium castaneum]>gi|642920952|ref|XP_008192628.1| PREDICTED: uncharacterized protein LOC663068 [Tribolium castaneum]>gi|642920955|ref|XP_008192629.1| PREDICTED: uncharacterized protein LOC663068 [Tribolium castaneum] 642920954 XM_008194407.1 385 0 PREDICTED: Tribolium castaneum uncharacterized LOC663068 (LOC663068), transcript variant X3, mRNA -- -- -- -- Q9W0K7 372 7.8e-34 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF02771//PF00157//PF00651//PF04218//PF05225 Acyl-CoA dehydrogenase, N-terminal domain//Pou domain - N-terminal to homeobox domain//BTB/POZ domain//CENP-B N-terminal DNA-binding domain//helix-turn-helix, Psq domain GO:0008152//GO:0006355//GO:0055114 metabolic process//regulation of transcription, DNA-templated//oxidation-reduction process GO:0003677//GO:0005515//GO:0050660//GO:0016627//GO:0003700 DNA binding//protein binding//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.60420 BP_3 5.61 0.96 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60424 BP_3 21.66 0.38 3057 642922398 XP_008193141.1 2127 4.6e-236 PREDICTED: adenylate kinase isoenzyme 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y6K8 307 2.1e-26 Adenylate kinase isoenzyme 5 OS=Homo sapiens GN=AK5 PE=1 SV=2 PF00004//PF09107 ATPase family associated with various cellular activities (AAA)//Elongation factor SelB, winged helix GO:0001514//GO:0006448 selenocysteine incorporation//regulation of translational elongation GO:0003746//GO:0005525//GO:0003723//GO:0005524 translation elongation factor activity//GTP binding//RNA binding//ATP binding GO:0005737//GO:0005840 cytoplasm//ribosome KOG3079 Uridylate kinase/adenylate kinase Cluster-8309.60430 BP_3 21.04 0.31 3559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60431 BP_3 9.33 0.37 1503 91088447 XP_968769.1 946 2.0e-99 PREDICTED: PI-PLC X domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270012211|gb|EFA08659.1| hypothetical protein TcasGA2_TC006324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58EK3 556 1.4e-55 PI-PLC X domain-containing protein 3 OS=Danio rerio GN=plcxd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4306 Glycosylphosphatidylinositol-specific phospholipase C Cluster-8309.60432 BP_3 131.07 1.78 3833 642918821 XP_972786.2 1179 4.8e-126 PREDICTED: TNF receptor-associated factor 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 298 2.9e-25 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF06009//PF02176 Acyltransferase family//Laminin Domain II//TRAF-type zinc finger GO:0007155 cell adhesion GO:0008270//GO:0016747 zinc ion binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.60433 BP_3 17.75 0.58 1767 546678692 ERL89260.1 1516 1.9e-165 hypothetical protein D910_06633, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 Q9UIQ6 815 1.5e-85 Leucyl-cystinyl aminopeptidase OS=Homo sapiens GN=LNPEP PE=1 SV=3 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.60436 BP_3 69.13 3.47 1252 270009426 EFA05874.1 312 5.4e-26 hypothetical protein TcasGA2_TC008683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6044 BP_3 210.05 1.59 6673 189236708 XP_974222.2 1766 7.2e-194 PREDICTED: uncharacterized protein LOC663068 [Tribolium castaneum]>gi|642920952|ref|XP_008192628.1| PREDICTED: uncharacterized protein LOC663068 [Tribolium castaneum]>gi|642920955|ref|XP_008192629.1| PREDICTED: uncharacterized protein LOC663068 [Tribolium castaneum] 642920954 XM_008194407.1 385 0 PREDICTED: Tribolium castaneum uncharacterized LOC663068 (LOC663068), transcript variant X3, mRNA -- -- -- -- Q9W0K7 372 1.3e-33 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF00651//PF00157//PF05225//PF04218//PF02771 BTB/POZ domain//Pou domain - N-terminal to homeobox domain//helix-turn-helix, Psq domain//CENP-B N-terminal DNA-binding domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0006355//GO:0055114//GO:0008152 regulation of transcription, DNA-templated//oxidation-reduction process//metabolic process GO:0050660//GO:0016627//GO:0003700//GO:0003677//GO:0005515 flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors//transcription factor activity, sequence-specific DNA binding//DNA binding//protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.60442 BP_3 6.94 0.36 1210 270007554 EFA04002.1 756 1.7e-77 hypothetical protein TcasGA2_TC014151 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 536 2.3e-53 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13414//PF13176//PF13371//PF13374//PF13181//PF00515 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1124 FOG: TPR repeat Cluster-8309.60444 BP_3 904.78 38.18 1434 546673028 ERL84714.1 1425 5.4e-155 hypothetical protein D910_02139 [Dendroctonus ponderosae] 826423471 XM_012671271.1 43 8.00683e-11 PREDICTED: Monomorium pharaonis putative inorganic phosphate cotransporter (LOC105831269), mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 716 3.6e-74 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.6045 BP_3 716.00 62.95 840 642929267 XP_008195763.1 591 1.6e-58 PREDICTED: uncharacterized protein LOC103313674 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.60457 BP_3 48.00 2.30 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60461 BP_3 47.78 0.39 6193 546680884 ERL91070.1 2675 2.6e-299 hypothetical protein D910_08412 [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 Q9NSI6 1521 7.1e-167 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens GN=BRWD1 PE=1 SV=4 PF10717//PF06507//PF00439//PF02798//PF00400 Occlusion-derived virus envelope protein ODV-E18//Auxin response factor//Bromodomain//Glutathione S-transferase, N-terminal domain//WD domain, G-beta repeat GO:0006355//GO:0009725 regulation of transcription, DNA-templated//response to hormone GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634//GO:0019031 nucleus//viral envelope KOG0644 Uncharacterized conserved protein, contains WD40 repeat and BROMO domains Cluster-8309.60468 BP_3 84.81 0.74 5826 91079028 XP_974924.1 1752 2.6e-192 PREDICTED: glutamate-rich WD repeat-containing protein 1 [Tribolium castaneum]>gi|270004178|gb|EFA00626.1| hypothetical protein TcasGA2_TC003502 [Tribolium castaneum] 687865299 LK927543.1 35 9.27599e-06 Caenorhabditis elegans genome assembly C_elegans_Bristol_N2_v1_5_4 ,scaffold CELN2_scaffold0000013 K14848 RRB1, GRWD1 ribosome assembly protein RRB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14848 Q9BQ67 1160 4.8e-125 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens GN=GRWD1 PE=1 SV=1 PF00400//PF09514//PF01119//PF08676 WD domain, G-beta repeat//SSXRD motif//DNA mismatch repair protein, C-terminal domain//MutL C terminal dimerisation domain GO:0006298//GO:0006355 mismatch repair//regulation of transcription, DNA-templated GO:0005515//GO:0030983//GO:0005524 protein binding//mismatched DNA binding//ATP binding GO:0005634 nucleus KOG0302 Ribosome Assembly protein Cluster-8309.60471 BP_3 99.27 1.79 2965 478253883 ENN74175.1 2319 2.4e-258 hypothetical protein YQE_09148, partial [Dendroctonus ponderosae] 887513412 KP641329.1 728 0 Leptinotarsa decemlineata putative aryl hydrocarbon receptor Dys mRNA, complete cds -- -- -- -- Q8IUM7 514 2.0e-50 Neuronal PAS domain-containing protein 4 OS=Homo sapiens GN=NPAS4 PE=1 SV=1 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.60476 BP_3 56.00 1.31 2353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60477 BP_3 8.36 1.03 683 645005043 XP_008217635.1 167 1.9e-09 PREDICTED: ribosomal RNA processing protein 1 homolog isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60483 BP_3 1.38 0.35 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60487 BP_3 3.00 0.46 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6049 BP_3 183.84 2.54 3775 642925496 XP_008194575.1 1114 1.6e-118 PREDICTED: serendipity locus protein alpha-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O77201 188 1.6e-12 Serendipity locus protein alpha OS=Drosophila virilis GN=Sry-alpha PE=3 SV=1 PF05482//PF02969//PF02637 Serendipity locus alpha protein (SRY-A)//TATA box binding protein associated factor (TAF)//GatB domain GO:0007349//GO:0006352 cellularization//DNA-templated transcription, initiation GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0016020//GO:0005634//GO:0005737 membrane//nucleus//cytoplasm KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.60497 BP_3 48.53 1.53 1817 478252789 ENN73182.1 1064 4.9e-113 hypothetical protein YQE_10236, partial [Dendroctonus ponderosae]>gi|546682445|gb|ERL92378.1| hypothetical protein D910_09692 [Dendroctonus ponderosae] -- -- -- -- -- K15108 SLC25A19, DNC, TPC1 solute carrier family 25 (mitochondrial thiamine pyrophosphate transporter), member 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15108 Q5IS35 624 2.1e-63 Mitochondrial thiamine pyrophosphate carrier OS=Macaca fascicularis GN=SLC25A19 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0752 Mitochondrial solute carrier protein Cluster-8309.6050 BP_3 46.34 0.63 3848 642925496 XP_008194575.1 1071 1.6e-113 PREDICTED: serendipity locus protein alpha-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O77201 188 1.6e-12 Serendipity locus protein alpha OS=Drosophila virilis GN=Sry-alpha PE=3 SV=1 PF05482//PF02969 Serendipity locus alpha protein (SRY-A)//TATA box binding protein associated factor (TAF) GO:0006352//GO:0007349 DNA-templated transcription, initiation//cellularization -- -- GO:0005737//GO:0005634//GO:0016020 cytoplasm//nucleus//membrane KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.60506 BP_3 29.47 0.93 1822 91092600 XP_970624.1 1403 2.4e-152 PREDICTED: vesicular glutamate transporter 2.2 [Tribolium castaneum]>gi|270006600|gb|EFA03048.1| hypothetical protein TcasGA2_TC010895 [Tribolium castaneum] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 790 1.2e-82 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.60507 BP_3 222.50 4.55 2651 91092600 XP_970624.1 1705 3.4e-187 PREDICTED: vesicular glutamate transporter 2.2 [Tribolium castaneum]>gi|270006600|gb|EFA03048.1| hypothetical protein TcasGA2_TC010895 [Tribolium castaneum] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 1011 4.2e-108 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.60516 BP_3 55.00 756.50 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60519 BP_3 7.00 0.98 636 -- -- -- -- -- 768311752 CP010980.1 459 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60520 BP_3 15.64 1.01 1041 817064117 XP_012253787.1 310 7.6e-26 PREDICTED: monocarboxylate transporter 3 isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q7RTX9 151 8.6e-09 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2504 Monocarboxylate transporter Cluster-8309.60525 BP_3 5.00 0.46 816 746870305 XP_011066332.1 136 9.0e-06 PREDICTED: uncharacterized protein LOC105153281 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60528 BP_3 47.78 0.53 4643 91079318 XP_967885.1 1936 9.7e-214 PREDICTED: kinesin-like protein KIF18A isoform X1 [Tribolium castaneum]>gi|270003520|gb|EEZ99967.1| hypothetical protein TcasGA2_TC002763 [Tribolium castaneum] -- -- -- -- -- K10401 KIF18_19 kinesin family member 18/19 http://www.genome.jp/dbget-bin/www_bget?ko:K10401 Q8NI77 1056 4.4e-113 Kinesin-like protein KIF18A OS=Homo sapiens GN=KIF18A PE=1 SV=2 PF02245//PF00225//PF04923 Methylpurine-DNA glycosylase (MPG)//Kinesin motor domain//Ninjurin GO:0042246//GO:0006284//GO:0007018//GO:0007155//GO:0007017 tissue regeneration//base-excision repair//microtubule-based movement//cell adhesion//microtubule-based process GO:0003777//GO:0003905//GO:0003677//GO:0005524//GO:0008017 microtubule motor activity//alkylbase DNA N-glycosylase activity//DNA binding//ATP binding//microtubule binding GO:0045298//GO:0005874//GO:0016021 tubulin complex//microtubule//integral component of membrane KOG0242 Kinesin-like protein Cluster-8309.60534 BP_3 113.37 0.99 5828 91091764 XP_969311.1 2691 3.5e-301 PREDICTED: DNA polymerase theta [Tribolium castaneum]>gi|270001085|gb|EEZ97532.1| hypothetical protein TcasGA2_TC011380 [Tribolium castaneum] -- -- -- -- -- K02349 POLQ DNA polymerase theta http://www.genome.jp/dbget-bin/www_bget?ko:K02349 O18475 2161 4.1e-241 DNA polymerase theta OS=Drosophila melanogaster GN=mus308 PE=1 SV=1 PF01612//PF03791//PF00270//PF00476 3'-5' exonuclease//KNOX2 domain//DEAD/DEAH box helicase//DNA polymerase family A GO:0006139//GO:0006260 nucleobase-containing compound metabolic process//DNA replication GO:0003887//GO:0005524//GO:0004386//GO:0003677//GO:0003676//GO:0008408 DNA-directed DNA polymerase activity//ATP binding//helicase activity//DNA binding//nucleic acid binding//3'-5' exonuclease activity GO:0042575//GO:0005634 DNA polymerase complex//nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.60543 BP_3 29.13 1.05 1627 642915433 XP_008190613.1 575 2.2e-56 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13302//PF13673//PF08445//PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- -- -- Cluster-8309.60544 BP_3 6.40 0.56 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60545 BP_3 1.00 6.78 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60547 BP_3 173.90 4.87 2013 478250007 ENN70513.1 662 2.3e-66 hypothetical protein YQE_12689, partial [Dendroctonus ponderosae] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q6DI51 444 1.8e-42 Nucleoside diphosphate kinase 6 OS=Danio rerio GN=nme6 PE=2 SV=1 PF00334 Nucleoside diphosphate kinase GO:0006165//GO:0006206//GO:0006241//GO:0006183//GO:0006228//GO:0006144 nucleoside diphosphate phosphorylation//pyrimidine nucleobase metabolic process//CTP biosynthetic process//GTP biosynthetic process//UTP biosynthetic process//purine nucleobase metabolic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.60551 BP_3 68.00 0.74 4697 123469906 XP_001318162.1 520 1.5e-49 viral A-type inclusion protein [Trichomonas vaginalis G3]>gi|121900914|gb|EAY05939.1| viral A-type inclusion protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54G05 269 8.1e-22 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF06160//PF10473//PF04513//PF00038//PF15898//PF02050//PF04611//PF05791//PF04977//PF13851 Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Baculovirus polyhedron envelope protein, PEP, C terminus//Intermediate filament protein//cGMP-dependent protein kinase interacting domain//Flagellar FliJ protein//Mating type protein A alpha Y mating type dependent binding region//Bacillus haemolytic enterotoxin (HBL)//Septum formation initiator//Growth-arrest specific micro-tubule binding GO:0006935//GO:0048870//GO:0000921//GO:0071973//GO:0006355//GO:0007049//GO:0019953//GO:0009405 chemotaxis//cell motility//septin ring assembly//bacterial-type flagellum-dependent cell motility//regulation of transcription, DNA-templated//cell cycle//sexual reproduction//pathogenesis GO:0003774//GO:0042803//GO:0019901//GO:0045502//GO:0008134//GO:0005198 motor activity//protein homodimerization activity//protein kinase binding//dynein binding//transcription factor binding//structural molecule activity GO:0016020//GO:0030286//GO:0019031//GO:0005667//GO:0009288//GO:0031514//GO:0016021//GO:0019028//GO:0005940//GO:0005882 membrane//dynein complex//viral envelope//transcription factor complex//bacterial-type flagellum//motile cilium//integral component of membrane//viral capsid//septin ring//intermediate filament -- -- Cluster-8309.60556 BP_3 27.27 1.94 968 189239732 XP_968903.2 377 1.2e-33 PREDICTED: vitellogenin receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98163 145 4.0e-08 Putative vitellogenin receptor OS=Drosophila melanogaster GN=yl PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60565 BP_3 2.00 0.37 549 189237043 XP_001810887.1 917 1.7e-96 PREDICTED: neuroligin-4, Y-linked [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N0W4 400 6.1e-38 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF07859//PF03403 alpha/beta hydrolase fold//Platelet-activating factor acetylhydrolase, isoform II GO:0016042//GO:0008152//GO:0046486 lipid catabolic process//metabolic process//glycerolipid metabolic process GO:0003847//GO:0016787 1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG1516 Carboxylesterase and related proteins Cluster-8309.60570 BP_3 2.00 0.36 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60577 BP_3 256.61 3.55 3773 270012124 EFA08572.1 1016 3.8e-107 hypothetical protein TcasGA2_TC006227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI18 264 2.5e-21 Protein yellow OS=Drosophila pseudoobscura pseudoobscura GN=y PE=3 SV=2 PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.60584 BP_3 32.23 0.34 4854 642913192 XP_008201430.1 2888 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase SHPRH isoform X1 [Tribolium castaneum] -- -- -- -- -- K15710 SHPRH E3 ubiquitin-protein ligase SHPRH http://www.genome.jp/dbget-bin/www_bget?ko:K15710 Q7TPQ3 991 1.6e-105 E3 ubiquitin-protein ligase SHPRH OS=Mus musculus GN=Shprh PE=1 SV=1 PF12861//PF13374//PF02891//PF00515//PF00176//PF13176//PF13639//PF00628//PF14634//PF12678//PF00097 Anaphase-promoting complex subunit 11 RING-H2 finger//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat//SNF2 family N-terminal domain//Tetratricopeptide repeat//Ring finger domain//PHD-finger//zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270//GO:0005524 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding//ATP binding GO:0005680 anaphase-promoting complex KOG0298 DEAD box-containing helicase-like transcription factor/DNA repair protein Cluster-8309.60587 BP_3 89.00 1.91 2538 91082451 XP_971337.1 637 2.3e-63 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [Tribolium castaneum]>gi|270007152|gb|EFA03600.1| hypothetical protein TcasGA2_TC013687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TV66 410 1.9e-38 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 OS=Oryctolagus cuniculus GN=HCN4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60589 BP_3 3.00 0.50 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6059 BP_3 2.25 1.13 386 91078218 XP_969246.1 393 6.7e-36 PREDICTED: ubiquitin-like protein 5 [Tribolium castaneum]>gi|270002984|gb|EEZ99431.1| hypothetical protein TcasGA2_TC030562 [Tribolium castaneum] 815820526 XM_012376058.1 88 1.95132e-36 PREDICTED: Linepithema humile ubiquitin-like protein 5 (LOC105677441), mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q791B0 357 4.1e-33 Ubiquitin-like protein 5 OS=Psammomys obesus GN=UBL5 PE=3 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-8309.60590 BP_3 48.41 0.53 4655 270016648 EFA13094.1 274 5.1e-21 hypothetical protein TcasGA2_TC012963 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895//PF10181//PF00098//PF05531 Signal transducing histidine kinase, homodimeric domain//GPI-GlcNAc transferase complex, PIG-H component//Zinc knuckle//Nucleopolyhedrovirus P10 protein GO:0016310//GO:0000160//GO:0006935 phosphorylation//phosphorelay signal transduction system//chemotaxis GO:0008270//GO:0004673//GO:0003676//GO:0017176//GO:0000155 zinc ion binding//protein histidine kinase activity//nucleic acid binding//phosphatidylinositol N-acetylglucosaminyltransferase activity//phosphorelay sensor kinase activity GO:0005737//GO:0009365//GO:0019028 cytoplasm//protein histidine kinase complex//viral capsid -- -- Cluster-8309.60591 BP_3 80.52 0.93 4466 662195961 XP_008470989.1 905 3.3e-94 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60594 BP_3 220.64 11.09 1251 189233697 XP_966459.2 900 3.5e-94 PREDICTED: uncharacterized protein C17orf59 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D6W8 247 7.6e-20 Uncharacterized protein C17orf59 homolog OS=Mus musculus PE=1 SV=1 PF00413 Matrixin GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG4514 Uncharacterized conserved protein Cluster-8309.60597 BP_3 9.00 2.29 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60601 BP_3 43.03 1.04 2284 815769362 XP_012234794.1 1694 5.5e-186 PREDICTED: synaptotagmin-7 isoform X4 [Linepithema humile] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 870 8.0e-92 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.60607 BP_3 44.65 2.32 1219 332374428 AEE62355.1 765 1.6e-78 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14530 RPP40 ribonucleases P/MRP protein subunit RPP40 http://www.genome.jp/dbget-bin/www_bget?ko:K14530 Q5BK64 292 4.5e-25 Ribonuclease P protein subunit p40 OS=Rattus norvegicus GN=Rpp40 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60608 BP_3 10.86 0.33 1888 642926488 XP_008191976.1 1703 4.1e-187 PREDICTED: probable ATP-dependent RNA helicase kurz [Tribolium castaneum]>gi|270009095|gb|EFA05543.1| hypothetical protein TcasGA2_TC015731 [Tribolium castaneum] -- -- -- -- -- K14780 DHX37, DHR1 ATP-dependent RNA helicase DHX37/DHR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14780 O46072 1223 7.7e-133 Probable ATP-dependent RNA helicase kurz OS=Drosophila melanogaster GN=kz PE=1 SV=1 PF04408 Helicase associated domain (HA2) -- -- GO:0008026//GO:0003676//GO:0005524//GO:0004386 ATP-dependent helicase activity//nucleic acid binding//ATP binding//helicase activity -- -- KOG0926 DEAH-box RNA helicase Cluster-8309.6061 BP_3 30.72 0.43 3718 665808740 XP_008552705.1 230 5.2e-16 PREDICTED: uncharacterized protein LOC103574919 isoform X2 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60612 BP_3 335.58 15.43 1340 642914590 XP_008190277.1 281 2.3e-22 PREDICTED: venom prothrombin activator trocarin-D-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05589 136 6.1e-07 Urokinase-type plasminogen activator OS=Bos taurus GN=PLAU PE=2 SV=1 PF15220//PF00089 Hypoxia-inducible lipid droplet-associated//Trypsin GO:0001819//GO:0010884//GO:0006508//GO:0008284 positive regulation of cytokine production//positive regulation of lipid storage//proteolysis//positive regulation of cell proliferation GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.60613 BP_3 53.60 2.77 1224 642924351 XP_008194259.1 483 7.8e-46 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00641//PF04810//PF00628 Zn-finger in Ran binding protein and others//Sec23/Sec24 zinc finger//PHD-finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.60619 BP_3 2.00 5.17 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60629 BP_3 267.84 3.98 3532 91093355 XP_969078.1 2088 1.8e-231 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IWG1 594 1.2e-59 WD repeat-containing protein 63 OS=Homo sapiens GN=WDR63 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.60630 BP_3 2.51 0.50 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.60631 BP_3 1.00 0.44 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60634 BP_3 3.00 0.77 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60638 BP_3 9.00 0.60 1012 675366330 KFM59232.1 337 5.5e-29 Retrovirus-related Pol polyprotein from transposon 412, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.60639 BP_3 14.00 0.71 1239 675882076 XP_009026540.1 151 2.5e-07 hypothetical protein HELRODRAFT_179452 [Helobdella robusta]>gi|555692151|gb|ESN95383.1| hypothetical protein HELRODRAFT_179452 [Helobdella robusta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06160//PF06456//PF01105//PF04513//PF04108//PF17078//PF04508 Septation ring formation regulator, EzrA//Arfaptin-like domain//emp24/gp25L/p24 family/GOLD//Baculovirus polyhedron envelope protein, PEP, C terminus//Autophagy protein Apg17//SWI5-dependent HO expression protein 3//Viral A-type inclusion protein repeat GO:0051028//GO:0006914//GO:0000921//GO:0048309//GO:0006810//GO:0016032 mRNA transport//autophagy//septin ring assembly//endoplasmic reticulum inheritance//transport//viral process GO:0005198//GO:0019904 structural molecule activity//protein domain specific binding GO:0019031//GO:0005940//GO:0019028//GO:0016021 viral envelope//septin ring//viral capsid//integral component of membrane -- -- Cluster-8309.6064 BP_3 18.00 0.48 2103 642937652 XP_966876.3 509 1.3e-48 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1W2 348 2.5e-31 Zinc finger protein 710 OS=Homo sapiens GN=ZNF710 PE=2 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.60642 BP_3 150.27 3.33 2468 642912489 XP_008200886.1 1862 2.0e-205 PREDICTED: Fanconi anemia group I protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVI1 283 1.0e-23 Fanconi anemia group I protein OS=Homo sapiens GN=FANCI PE=1 SV=4 PF04557//PF00042//PF01294 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//Globin//Ribosomal protein L13e GO:0042254//GO:0006425//GO:0006412 ribosome biogenesis//glutaminyl-tRNA aminoacylation//translation GO:0020037//GO:0003735//GO:0000166//GO:0004819//GO:0005524//GO:0019825 heme binding//structural constituent of ribosome//nucleotide binding//glutamine-tRNA ligase activity//ATP binding//oxygen binding GO:0005737//GO:0005840//GO:0005622 cytoplasm//ribosome//intracellular KOG4553 Uncharacterized conserved protein Cluster-8309.60644 BP_3 113.25 4.36 1545 642925935 XP_008194702.1 315 3.0e-26 PREDICTED: uncharacterized protein LOC103313383 [Tribolium castaneum]>gi|270008587|gb|EFA05035.1| hypothetical protein TcasGA2_TC015123 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60646 BP_3 45.01 1.49 1751 642937544 XP_008199089.1 962 3.2e-101 PREDICTED: major facilitator superfamily domain-containing protein 9-like isoform X2 [Tribolium castaneum]>gi|270001229|gb|EEZ97676.1| hypothetical protein TcasGA2_TC016221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0T7 437 9.9e-42 Major facilitator superfamily domain-containing protein 9 OS=Mus musculus GN=Mfsd9 PE=2 SV=1 PF05121//PF07690 Gas vesicle protein K//Major Facilitator Superfamily GO:0031412//GO:0055085 gas vesicle organization//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.60649 BP_3 42.25 0.69 3259 260781332 XP_002585771.1 633 8.4e-63 hypothetical protein BRAFLDRAFT_257357 [Branchiostoma floridae]>gi|229270812|gb|EEN41782.1| hypothetical protein BRAFLDRAFT_257357, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- A6NN14 429 1.6e-40 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF16622//PF00096//PF13465 zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.60650 BP_3 4.00 0.50 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60651 BP_3 1.00 0.35 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60652 BP_3 19.05 0.62 1784 189240189 XP_975214.2 379 1.3e-33 PREDICTED: ABC transporter G family member 14 isoform X2 [Tribolium castaneum]>gi|270011649|gb|EFA08097.1| hypothetical protein TcasGA2_TC005701 [Tribolium castaneum] 642932113 XM_970121.3 139 4.3085e-64 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X2, mRNA -- -- -- -- Q84TH5 130 4.0e-06 ABC transporter G family member 25 OS=Arabidopsis thaliana GN=ABCG25 PE=2 SV=1 PF01061//PF15202//PF02932//PF02749 ABC-2 type transporter//Adipogenin//Neurotransmitter-gated ion-channel transmembrane region//Quinolinate phosphoribosyl transferase, N-terminal domain GO:0006811//GO:0006200//GO:0045444 ion transport//obsolete ATP catabolic process//fat cell differentiation GO:0016763//GO:0016887//GO:0005524 transferase activity, transferring pentosyl groups//ATPase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.60659 BP_3 58.31 1.12 2799 642912894 XP_976337.2 794 1.6e-81 PREDICTED: uncharacterized protein LOC660220 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6066 BP_3 2.00 0.36 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6067 BP_3 2.00 0.42 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60673 BP_3 10.23 0.39 1543 328710225 XP_003244198.1 639 8.0e-64 PREDICTED: uncharacterized protein LOC100573332 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- B0BN95 151 1.3e-08 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60674 BP_3 28.63 1.30 1356 642913139 XP_008201409.1 1195 2.4e-128 PREDICTED: lachesin-like [Tribolium castaneum] 642913138 XM_008203187.1 74 4.42324e-28 PREDICTED: Tribolium castaneum lachesin-like (LOC663748), mRNA -- -- -- -- Q24372 337 3.0e-30 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60681 BP_3 12.00 0.79 1025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60682 BP_3 5.00 1.09 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60683 BP_3 8.55 1.14 653 642934526 XP_008197699.1 561 3.8e-55 PREDICTED: platelet-derived growth factor receptor alpha isoform X2 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 370 2.2e-34 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF02319//PF00069 Protein tyrosine kinase//E2F/DP family winged-helix DNA-binding domain//Protein kinase domain GO:0006355//GO:0006468 regulation of transcription, DNA-templated//protein phosphorylation GO:0005524//GO:0003700//GO:0004672 ATP binding//transcription factor activity, sequence-specific DNA binding//protein kinase activity GO:0005667 transcription factor complex KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.60685 BP_3 281.00 118.29 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60686 BP_3 178.64 4.79 2091 123227460 CAM27169.1 257 2.1e-19 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] 564252665 XM_006265293.1 115 1.11195e-50 PREDICTED: Alligator mississippiensis Sp5 transcription factor (SP5), mRNA K09199 SP9 transcription factor Sp9 http://www.genome.jp/dbget-bin/www_bget?ko:K09199 Q8VI67 577 6.9e-58 Transcription factor Sp7 OS=Mus musculus GN=Sp7 PE=1 SV=1 PF13912//PF13465//PF00096//PF15761 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Immortalisation up-regulated protein -- -- GO:0046872 metal ion binding GO:0005634 nucleus -- -- Cluster-8309.60691 BP_3 82.69 2.41 1943 91079957 XP_969398.1 651 4.1e-65 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I3LM39 158 2.5e-09 Cyclic GMP-AMP synthase OS=Sus scrofa GN=MB21D1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60692 BP_3 19.96 0.79 1508 751232467 XP_011169850.1 297 3.6e-24 PREDICTED: uncharacterized protein LOC105202865 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.60694 BP_3 104.28 4.47 1417 91079957 XP_969398.1 592 2.1e-58 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I3LM39 158 1.8e-09 Cyclic GMP-AMP synthase OS=Sus scrofa GN=MB21D1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60698 BP_3 4.00 0.43 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60701 BP_3 10.00 0.70 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60707 BP_3 139.14 1.64 4378 642919071 XP_008191721.1 4597 0.0e+00 PREDICTED: MAP kinase-activating death domain protein isoform X2 [Tribolium castaneum] 780680996 XM_011699227.1 90 1.8537e-36 PREDICTED: Wasmannia auropunctata MAP kinase-activating death domain protein (LOC105455707), transcript variant X7, mRNA -- -- -- -- Q9VXY2 3195 0.0e+00 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.60713 BP_3 69.52 3.42 1271 642917872 XP_969181.2 297 3.0e-24 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7B4 153 6.2e-09 Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens GN=SMYD3 PE=1 SV=4 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.60716 BP_3 133.18 5.22 1522 642915148 XP_008190494.1 545 6.3e-53 PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915150|ref|XP_008190495.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915152|ref|XP_008190496.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915154|ref|XP_008190497.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6073 BP_3 4.25 0.36 865 642929034 XP_008195662.1 343 9.5e-30 PREDICTED: borealin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLD6 143 6.1e-08 Borealin OS=Drosophila melanogaster GN=borr PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60731 BP_3 14.73 0.45 1859 554886791 XP_005952956.1 562 8.2e-55 PREDICTED: zinc finger protein 235-like [Haplochromis burtoni] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 545 3.2e-54 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF05864//PF07776//PF03604//PF00096//PF13912//PF00412//PF13465//PF01096//PF07975//PF01667 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Zinc-finger associated domain (zf-AD)//DNA directed RNA polymerase, 7 kDa subunit//Zinc finger, C2H2 type//C2H2-type zinc finger//LIM domain//Zinc-finger double domain//Transcription factor S-II (TFIIS)//TFIIH C1-like domain//Ribosomal protein S27 GO:0006206//GO:0006351//GO:0006144//GO:0006412//GO:0042254//GO:0006281 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//translation//ribosome biogenesis//DNA repair GO:0003676//GO:0046872//GO:0003677//GO:0003735//GO:0008270//GO:0003899 nucleic acid binding//metal ion binding//DNA binding//structural constituent of ribosome//zinc ion binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005840//GO:0005622//GO:0005730 nucleus//ribosome//intracellular//nucleolus -- -- Cluster-8309.60733 BP_3 4.40 0.33 939 157133240 XP_001656195.1 220 1.9e-15 AAEL012685-PA [Aedes aegypti]>gi|108870900|gb|EAT35125.1| AAEL012685-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60736 BP_3 3.00 0.75 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6074 BP_3 49.00 1.45 1921 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60740 BP_3 188.26 3.52 2871 270004045 EFA00493.1 1898 1.5e-209 hypothetical protein TcasGA2_TC003353 [Tribolium castaneum] -- -- -- -- -- K05127 PTK7, CCK4 PTK7 protein tyrosine kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05127 B4GBH0 1000 8.5e-107 Tyrosine-protein kinase-like otk OS=Drosophila persimilis GN=otk PE=3 SV=1 PF13895//PF00069//PF07714 Immunoglobulin domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- -- -- Cluster-8309.60743 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60757 BP_3 100.00 6.04 1090 642938202 XP_008193760.1 265 1.3e-20 PREDICTED: uncharacterized protein LOC103313115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6076 BP_3 4.00 0.56 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60761 BP_3 26.13 0.42 3295 642923122 XP_008193618.1 2651 8.5e-297 PREDICTED: cyclic nucleotide-gated cation channel beta-1 [Tribolium castaneum]>gi|270007574|gb|EFA04022.1| hypothetical protein TcasGA2_TC014251 [Tribolium castaneum] -- -- -- -- -- K04952 CNGB1 cyclic nucleotide gated channel beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04952 Q28181 1066 2.2e-114 Cyclic nucleotide-gated cation channel beta-1 OS=Bos taurus GN=CNGB1 PE=1 SV=1 PF00520//PF11789//PF00440 Ion transport protein//Zinc-finger of the MIZ type in Nse subunit//Bacterial regulatory proteins, tetR family GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0008270//GO:0005216//GO:0003677 zinc ion binding//ion channel activity//DNA binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0499 Cyclic nucleotide-gated cation channel CNCG4 Cluster-8309.60763 BP_3 61.59 0.68 4645 861602714 KMQ83970.1 170 5.9e-09 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05531//PF00098//PF02895//PF10181 Nucleopolyhedrovirus P10 protein//Zinc knuckle//Signal transducing histidine kinase, homodimeric domain//GPI-GlcNAc transferase complex, PIG-H component GO:0000160//GO:0006935//GO:0016310 phosphorelay signal transduction system//chemotaxis//phosphorylation GO:0000155//GO:0017176//GO:0003676//GO:0008270//GO:0004673 phosphorelay sensor kinase activity//phosphatidylinositol N-acetylglucosaminyltransferase activity//nucleic acid binding//zinc ion binding//protein histidine kinase activity GO:0019028//GO:0009365//GO:0005737 viral capsid//protein histidine kinase complex//cytoplasm -- -- Cluster-8309.60766 BP_3 995.84 96.33 790 91079476 XP_967809.1 460 2.3e-43 PREDICTED: cytochrome b5 [Tribolium castaneum]>gi|270003450|gb|EEZ99897.1| hypothetical protein TcasGA2_TC002681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49098 215 2.5e-16 Cytochrome b5 OS=Nicotiana tabacum PE=2 SV=1 -- -- -- -- GO:0046872//GO:0020037 metal ion binding//heme binding -- -- KOG0537 Cytochrome b5 Cluster-8309.60768 BP_3 96.08 2.11 2489 270015871 EFA12319.1 2573 7.1e-288 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P19174 1632 3.8e-180 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens GN=PLCG1 PE=1 SV=1 PF13405//PF00036//PF13833//PF13499 EF-hand domain//EF hand//EF-hand domain pair//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG1264 Phospholipase C Cluster-8309.60771 BP_3 44.72 3.26 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60775 BP_3 2.64 0.33 678 91092264 XP_967363.1 382 2.2e-34 PREDICTED: peptide deformylase, mitochondrial [Tribolium castaneum]>gi|270001218|gb|EEZ97665.1| hypothetical protein TcasGA2_TC016210 [Tribolium castaneum] -- -- -- -- -- K01462 PDF, def peptide deformylase http://www.genome.jp/dbget-bin/www_bget?ko:K01462 Q9HBH1 255 4.9e-21 Peptide deformylase, mitochondrial OS=Homo sapiens GN=PDF PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3137 Peptide deformylase Cluster-8309.60786 BP_3 192.82 1.46 6637 91094669 XP_972505.1 7421 0.0e+00 PREDICTED: intraflagellar transport protein osm-1 [Tribolium castaneum]>gi|270016462|gb|EFA12908.1| hypothetical protein TcasGA2_TC006977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W040 4776 0.0e+00 Intraflagellar transport protein osm-1 OS=Drosophila melanogaster GN=osm-1 PE=3 SV=3 PF13414//PF00637//PF13181//PF00515 TPR repeat//Region in Clathrin and VPS//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0005622 intracellular KOG3616 Selective LIM binding factor Cluster-8309.60789 BP_3 16.20 0.33 2633 189239641 XP_972129.2 1708 1.5e-187 PREDICTED: fukutin-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CG64 917 3.3e-97 Fukutin-related protein OS=Mus musculus GN=Fkrp PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6079 BP_3 94.61 2.32 2261 642928970 XP_008195639.1 186 4.0e-11 PREDICTED: FK506-binding protein 5-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60791 BP_3 20.83 0.46 2457 546680705 ERL90931.1 1474 1.9e-160 hypothetical protein D910_08274, partial [Dendroctonus ponderosae] 642930215 XM_965099.2 234 9.23638e-117 PREDICTED: Tribolium castaneum protein UBASH3A homolog (LOC658737), transcript variant X1, mRNA K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 858 2.1e-90 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.60792 BP_3 16.16 0.59 1611 642930216 XP_970192.2 186 2.8e-11 PREDICTED: protein UBASH3A homolog isoform X1 [Tribolium castaneum] 642930215 XM_965099.2 69 3.17599e-25 PREDICTED: Tribolium castaneum protein UBASH3A homolog (LOC658737), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.608 BP_3 16.19 0.32 2752 270014082 EFA10530.1 1284 2.3e-138 hypothetical protein TcasGA2_TC012784 [Tribolium castaneum] 642936326 XM_964264.3 365 0 PREDICTED: Tribolium castaneum hemicentin-2-like (LOC657829), transcript variant X1, mRNA -- -- -- -- Q62718 136 1.2e-06 Neurotrimin OS=Rattus norvegicus GN=Ntm PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60804 BP_3 4.00 0.35 847 313760436 BAJ41248.1 408 2.7e-37 broad-complex isoform A-NZe [Frankliniella occidentalis]>gi|313760452|dbj|BAJ41256.1| broad-complex isoform B-NZe [Frankliniella occidentalis] -- -- -- -- -- K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q24206 379 2.6e-35 Broad-complex core protein isoform 6 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6081 BP_3 110.76 3.65 1753 91094825 XP_971125.1 1656 1.1e-181 PREDICTED: ATPase WRNIP1-like [Tribolium castaneum] -- -- -- -- -- K07478 ycaJ putative ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K07478 Q96S55 1112 5.3e-120 ATPase WRNIP1 OS=Homo sapiens GN=WRNIP1 PE=1 SV=2 PF04851//PF01637//PF07726//PF15926//PF00931//PF00910//PF00158//PF01443//PF05496//PF07728//PF01695//PF14532//PF07724//PF00004 Type III restriction enzyme, res subunit//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//E3 ubiquitin-protein ligase RNF220//NB-ARC domain//RNA helicase//Sigma-54 interaction domain//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0016567//GO:0006355//GO:0006281//GO:0090263 DNA recombination//protein ubiquitination//regulation of transcription, DNA-templated//DNA repair//positive regulation of canonical Wnt signaling pathway GO:0009378//GO:0003724//GO:0043531//GO:0003723//GO:0003677//GO:0016887//GO:0008134//GO:0005524//GO:0016787 four-way junction helicase activity//RNA helicase activity//ADP binding//RNA binding//DNA binding//ATPase activity//transcription factor binding//ATP binding//hydrolase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase Cluster-8309.60815 BP_3 285.30 7.09 2230 91080175 XP_970509.1 607 6.0e-60 PREDICTED: organic solute transporter alpha-like protein [Tribolium castaneum]>gi|270005672|gb|EFA02120.1| hypothetical protein TcasGA2_TC007767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VVV2 175 3.0e-11 Organic solute transporter alpha-like protein OS=Drosophila melanogaster GN=CG6836 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60816 BP_3 4547.36 136.79 1894 91080175 XP_970509.1 979 3.7e-103 PREDICTED: organic solute transporter alpha-like protein [Tribolium castaneum]>gi|270005672|gb|EFA02120.1| hypothetical protein TcasGA2_TC007767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VVV2 234 3.7e-18 Organic solute transporter alpha-like protein OS=Drosophila melanogaster GN=CG6836 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60818 BP_3 4.00 0.75 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60819 BP_3 28.79 0.34 4420 642930333 XP_008196351.1 1472 5.9e-160 PREDICTED: protein Wnt-7b [Tribolium castaneum] -- -- -- -- -- K00572 WNT7 wingless-type MMTV integration site family, member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00572 P28465 949 1.1e-100 Protein Wnt-2 OS=Drosophila melanogaster GN=Wnt2 PE=2 SV=2 PF00110 wnt family GO:0007165//GO:0016055//GO:0007275 signal transduction//Wnt signaling pathway//multicellular organismal development GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.60820 BP_3 8.33 0.50 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60825 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60831 BP_3 18.00 0.53 1929 270017034 EFA13480.1 1034 1.6e-109 hypothetical protein TcasGA2_TC002031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX7 212 1.3e-15 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60833 BP_3 11.51 0.45 1538 642927147 XP_008195157.1 228 3.6e-16 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60834 BP_3 3.00 0.49 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60836 BP_3 126.31 3.67 1949 546685591 ERL95078.1 331 5.3e-28 hypothetical protein D910_12348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SV66 128 7.5e-06 Coiled-coil domain-containing protein 42A OS=Mus musculus GN=Ccdc42 PE=2 SV=2 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.60840 BP_3 14.28 0.41 1953 642938915 XP_008195579.1 461 4.4e-43 PREDICTED: suppressor APC domain-containing protein 2 [Tribolium castaneum]>gi|270016161|gb|EFA12609.1| hypothetical protein TcasGA2_TC006850 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0006355//GO:0009271 regulation of transcription, DNA-templated//phage shock -- -- -- -- -- -- Cluster-8309.60844 BP_3 2.00 1.37 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60845 BP_3 16.00 0.59 1594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60846 BP_3 4.00 0.79 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60848 BP_3 198.00 6.11 1853 91076348 XP_966701.1 1604 1.2e-175 PREDICTED: COP9 signalosome complex subunit 2 [Tribolium castaneum]>gi|270002546|gb|EEZ98993.1| hypothetical protein TcasGA2_TC004854 [Tribolium castaneum] 241700453 XM_002411850.1 134 2.69535e-61 Ixodes scapularis COP9 signalosome, subunit CSN2, putative, mRNA K12176 COPS2, CSN2, TRIP15 COP9 signalosome complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12176 Q94899 1429 9.8e-157 COP9 signalosome complex subunit 2 OS=Drosophila melanogaster GN=alien PE=1 SV=2 PF00515//PF13181//PF01399//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//PCI domain//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.60853 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60854 BP_3 3.27 0.62 546 478263486 ENN81841.1 560 4.1e-55 hypothetical protein YQE_01779, partial [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q495M3 277 1.1e-23 Proton-coupled amino acid transporter 2 OS=Homo sapiens GN=SLC36A2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.60855 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60859 BP_3 2.00 10.73 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60860 BP_3 209.00 5.86 2011 91088999 XP_967603.1 2013 5.0e-223 PREDICTED: frizzled-4 [Tribolium castaneum]>gi|270012807|gb|EFA09255.1| frizzled 4 [Tribolium castaneum] 642932599 XM_962510.2 490 0 PREDICTED: Tribolium castaneum frizzled 4 (LOC655955), mRNA K02354 FZD4, fz4 frizzled 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02354 Q61088 900 2.3e-95 Frizzled-4 OS=Mus musculus GN=Fzd4 PE=1 SV=1 PF01534//PF01392 Frizzled/Smoothened family membrane region//Fz domain GO:0007165//GO:0007275//GO:0016055//GO:0007186//GO:0007166 signal transduction//multicellular organismal development//Wnt signaling pathway//G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway GO:0004930//GO:0042813//GO:0005515 G-protein coupled receptor activity//Wnt-activated receptor activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG3577 Smoothened and related G-protein-coupled receptors Cluster-8309.60861 BP_3 6.08 0.87 630 478256725 ENN76906.1 301 5.1e-25 hypothetical protein YQE_06554, partial [Dendroctonus ponderosae] -- -- -- -- -- K11390 CLYBL citrate lyase subunit beta-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11390 Q8N0X4 204 3.7e-15 Citrate lyase subunit beta-like protein, mitochondrial OS=Homo sapiens GN=CLYBL PE=1 SV=2 PF03328 HpcH/HpaI aldolase/citrate lyase family -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.60869 BP_3 3.00 0.50 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205 WH2 motif -- -- GO:0003779 actin binding -- -- -- -- Cluster-8309.60870 BP_3 39.84 1.61 1486 642939274 XP_008192907.1 1037 5.5e-110 PREDICTED: polycomb group protein Psc-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 P35820 630 3.5e-64 Polycomb group protein Psc OS=Drosophila melanogaster GN=Psc PE=1 SV=2 PF13639//PF05196//PF16685//PF12861//PF11789//PF05184//PF00097//PF12678//PF14634 Ring finger domain//PTN/MK heparin-binding protein family, N-terminal domain//zinc RING finger of MSL2//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc-finger of the MIZ type in Nse subunit//Saposin-like type B, region 1//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain GO:0040007//GO:0007165//GO:0008283//GO:0016567//GO:0006629 growth//signal transduction//cell proliferation//protein ubiquitination//lipid metabolic process GO:0008270//GO:0046872//GO:0008083//GO:0004842//GO:0061630//GO:0005515 zinc ion binding//metal ion binding//growth factor activity//ubiquitin-protein transferase activity//ubiquitin protein ligase activity//protein binding GO:0005680 anaphase-promoting complex KOG2660 Locus-specific chromosome binding proteins Cluster-8309.60873 BP_3 15.49 0.74 1294 478252139 ENN72569.1 382 4.3e-34 hypothetical protein YQE_10794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TXI4 134 1.0e-06 DNA double-strand break repair Rad50 ATPase OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) GN=rad50 PE=3 SV=1 PF06315//PF09730//PF06009//PF04111//PF02050//PF00769//PF05557//PF07926//PF06160 Isocitrate dehydrogenase kinase/phosphatase (AceK)//Microtubule-associated protein Bicaudal-D//Laminin Domain II//Autophagy protein Apg6//Flagellar FliJ protein//Ezrin/radixin/moesin family//Mitotic checkpoint protein//TPR/MLP1/MLP2-like protein//Septation ring formation regulator, EzrA GO:0006006//GO:0006935//GO:0000921//GO:0071973//GO:0007094//GO:0007155//GO:0006810//GO:0006914//GO:0006606 glucose metabolic process//chemotaxis//septin ring assembly//bacterial-type flagellum-dependent cell motility//mitotic spindle assembly checkpoint//cell adhesion//transport//autophagy//protein import into nucleus GO:0008092//GO:0016791//GO:0003774//GO:0008772 cytoskeletal protein binding//phosphatase activity//motor activity//[isocitrate dehydrogenase (NADP+)] kinase activity GO:0016020//GO:0019898//GO:0016021//GO:0005940//GO:0005794//GO:0009288//GO:0005737 membrane//extrinsic component of membrane//integral component of membrane//septin ring//Golgi apparatus//bacterial-type flagellum//cytoplasm -- -- Cluster-8309.60874 BP_3 34.01 1.04 1861 642922794 XP_008193328.1 521 4.7e-50 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 291 9.0e-25 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60876 BP_3 76.39 1.42 2880 270013369 EFA09817.1 674 1.3e-67 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- K17963 PPRC1, PRC peroxisome proliferator-activated receptor gamma coactivator-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17963 Q5VV67 232 9.7e-18 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Homo sapiens GN=PPRC1 PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- -- -- Cluster-8309.60881 BP_3 32.10 0.50 3408 642935622 XP_008198086.1 605 1.6e-59 PREDICTED: protein Tube-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K04733 IRAK4 interleukin-1 receptor-associated kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04733 Q08171 245 3.6e-19 Protein Tube OS=Drosophila virilis GN=tub PE=2 SV=1 PF07714//PF01674//PF00069 Protein tyrosine kinase//Lipase (class 2)//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0016787//GO:0005524 protein kinase activity//hydrolase activity//ATP binding -- -- -- -- Cluster-8309.60894 BP_3 25.56 1.66 1035 769867825 XP_011645940.1 206 8.7e-14 PREDICTED: LOW QUALITY PROTEIN: tyrosine-protein phosphatase 10D [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.60895 BP_3 33.01 0.35 4785 642936074 XP_008198292.1 521 1.2e-49 PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum]>gi|642936076|ref|XP_008198293.1| PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum] -- -- -- -- -- K11124 SMG6, EST1A protein SMG6 http://www.genome.jp/dbget-bin/www_bget?ko:K11124 P61406 234 9.4e-18 Telomerase-binding protein EST1A OS=Mus musculus GN=Smg6 PE=1 SV=1 PF03626//PF07347 Prokaryotic Cytochrome C oxidase subunit IV//NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) GO:0006814//GO:0006744//GO:0015992//GO:0042773//GO:0006120 sodium ion transport//ubiquinone biosynthetic process//proton transport//ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane -- -- Cluster-8309.60896 BP_3 57869.00 13776.33 494 805788495 XP_003703628.2 142 1.1e-06 PREDICTED: cuticle protein-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10297 Minimal binding motif of Hap4 for binding to Hap2/3/5 GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.60897 BP_3 7310.39 1509.70 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60898 BP_3 162.61 8.61 1202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60902 BP_3 3.70 0.38 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60904 BP_3 21.00 0.55 2126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60907 BP_3 1.00 0.57 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60908 BP_3 5.15 0.38 945 642934752 XP_008197796.1 247 1.4e-18 PREDICTED: transmembrane protein 129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZI25 204 5.6e-15 Transmembrane protein 129 OS=Gallus gallus GN=TMEM129 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60914 BP_3 115.25 1.27 4658 478253799 ENN74091.1 3155 0.0e+00 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 P29144 1597 8.2e-176 Tripeptidyl-peptidase 2 OS=Homo sapiens GN=TPP2 PE=1 SV=4 PF00082//PF09377 Subtilase family//SBDS protein C-terminal domain GO:0006508//GO:0042254 proteolysis//ribosome biogenesis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.60915 BP_3 131.00 6.89 1208 91092542 XP_968010.1 1192 4.7e-128 PREDICTED: nucleoporin Nup43 [Tribolium castaneum]>gi|270006621|gb|EFA03069.1| hypothetical protein TcasGA2_TC010925 [Tribolium castaneum] -- -- -- -- -- K14305 NUP43 nuclear pore complex protein Nup43 http://www.genome.jp/dbget-bin/www_bget?ko:K14305 Q8NFH3 595 3.3e-60 Nucleoporin Nup43 OS=Homo sapiens GN=NUP43 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60916 BP_3 36.50 1.02 2022 642934007 XP_008197600.1 825 2.8e-85 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K06210 NMNAT nicotinamide mononucleotide adenylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06210 Q96T66 392 1.9e-36 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 OS=Homo sapiens GN=NMNAT3 PE=1 SV=2 PF03028//PF01467//PF00008 Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like//EGF-like domain GO:0007018//GO:0007017//GO:0009058 microtubule-based movement//microtubule-based process//biosynthetic process GO:0003824//GO:0005515//GO:0003777 catalytic activity//protein binding//microtubule motor activity GO:0030286//GO:0005874 dynein complex//microtubule KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.60917 BP_3 3.02 0.34 725 769866963 XP_011645480.1 214 7.2e-15 PREDICTED: integrin beta-3 isoform X1 [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60918 BP_3 107.12 0.99 5522 642928752 XP_008199768.1 3819 0.0e+00 PREDICTED: nephrin isoform X1 [Tribolium castaneum]>gi|642928754|ref|XP_008199769.1| PREDICTED: nephrin isoform X1 [Tribolium castaneum] 642928753 XM_008201547.1 619 0 PREDICTED: Tribolium castaneum nephrin (LOC663184), transcript variant X2, mRNA -- -- -- -- Q9QZS7 215 1.7e-15 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60919 BP_3 12.00 0.34 1980 391329763 XP_003739337.1 451 6.5e-42 PREDICTED: uncharacterized protein LOC100902338 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- P11369 216 4.8e-16 LINE-1 retrotransposable element ORF2 protein OS=Mus musculus GN=Pol PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6092 BP_3 9.00 1.41 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60924 BP_3 538.28 5.60 4922 642930553 XP_966739.2 2865 0.0e+00 PREDICTED: uncharacterized protein LOC655137 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60933 BP_3 10.00 1.14 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60936 BP_3 15.31 0.80 1218 478257458 ENN77614.1 602 1.2e-59 hypothetical protein YQE_05909, partial [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 464 5.1e-45 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.60941 BP_3 107.36 2.33 2510 642914671 XP_008190309.1 831 7.1e-86 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 401 2.1e-37 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.60947 BP_3 41.66 0.48 4450 546676327 ERL87354.1 1850 8.7e-204 hypothetical protein D910_04749, partial [Dendroctonus ponderosae] 641658676 XM_001951259.3 168 8.22662e-80 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- P03952 447 1.7e-42 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.6095 BP_3 48.15 6.80 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60950 BP_3 12.62 0.74 1119 478258603 ENN78653.1 267 7.9e-21 hypothetical protein YQE_04826, partial [Dendroctonus ponderosae]>gi|546676607|gb|ERL87579.1| hypothetical protein D910_04970 [Dendroctonus ponderosae] -- -- -- -- -- K15439 EEF1E1, AIMP3 eukaryotic translation elongation factor 1 epsilon-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15439 P70102 159 1.1e-09 Eukaryotic translation elongation factor 1 epsilon-1 OS=Cricetulus griseus GN=EEF1E1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60951 BP_3 13.64 1.35 778 478258603 ENN78653.1 400 2.1e-36 hypothetical protein YQE_04826, partial [Dendroctonus ponderosae]>gi|546676607|gb|ERL87579.1| hypothetical protein D910_04970 [Dendroctonus ponderosae] -- -- -- -- -- K15439 EEF1E1, AIMP3 eukaryotic translation elongation factor 1 epsilon-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15439 P70102 218 1.1e-16 Eukaryotic translation elongation factor 1 epsilon-1 OS=Cricetulus griseus GN=EEF1E1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60954 BP_3 12.11 1.41 707 642923022 XP_008200499.1 181 4.7e-11 PREDICTED: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60956 BP_3 6.07 0.63 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.60960 BP_3 173.00 10.07 1120 91084843 XP_966905.1 775 9.9e-80 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 501 2.4e-49 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.60962 BP_3 26.27 0.31 4352 642914918 XP_008190441.1 1326 4.9e-143 PREDICTED: WD repeat-containing protein 34-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96EX3 372 8.5e-34 WD repeat-containing protein 34 OS=Homo sapiens GN=WDR34 PE=1 SV=2 PF03306//PF01194//PF00400//PF14895//PF12515 Alpha-acetolactate decarboxylase//RNA polymerases N / 8 kDa subunit//WD domain, G-beta repeat//Protein phosphatase 1 inhibitor//Ca2+-ATPase N terminal autoinhibitory domain GO:0006144//GO:0006351//GO:0010923//GO:0045151//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//negative regulation of phosphatase activity//acetoin biosynthetic process//pyrimidine nucleobase metabolic process GO:0005515//GO:0003677//GO:0005516//GO:0003899//GO:0047605//GO:0019902 protein binding//DNA binding//calmodulin binding//DNA-directed RNA polymerase activity//acetolactate decarboxylase activity//phosphatase binding GO:0005730 nucleolus KOG3134 Predicted membrane protein Cluster-8309.60964 BP_3 88.84 1.07 4305 642914918 XP_008190441.1 1326 4.9e-143 PREDICTED: WD repeat-containing protein 34-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96EX3 372 8.4e-34 WD repeat-containing protein 34 OS=Homo sapiens GN=WDR34 PE=1 SV=2 PF00400//PF14895//PF12515//PF03306//PF01194 WD domain, G-beta repeat//Protein phosphatase 1 inhibitor//Ca2+-ATPase N terminal autoinhibitory domain//Alpha-acetolactate decarboxylase//RNA polymerases N / 8 kDa subunit GO:0006144//GO:0006351//GO:0010923//GO:0045151//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//negative regulation of phosphatase activity//acetoin biosynthetic process//pyrimidine nucleobase metabolic process GO:0005515//GO:0005516//GO:0003899//GO:0003677//GO:0047605//GO:0019902 protein binding//calmodulin binding//DNA-directed RNA polymerase activity//DNA binding//acetolactate decarboxylase activity//phosphatase binding GO:0005730 nucleolus -- -- Cluster-8309.60965 BP_3 1.00 0.50 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60967 BP_3 171.10 6.05 1655 189235082 XP_967321.2 1909 4.7e-211 PREDICTED: vacuolar fusion protein CCZ1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T102 1030 1.6e-110 Vacuolar fusion protein CCZ1 homolog OS=Xenopus laevis GN=ccz1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2622 Putative myrosinase precursor Cluster-8309.60968 BP_3 32.98 0.81 2244 189235082 XP_967321.2 1819 1.7e-200 PREDICTED: vacuolar fusion protein CCZ1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T102 986 2.8e-105 Vacuolar fusion protein CCZ1 homolog OS=Xenopus laevis GN=ccz1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2622 Putative myrosinase precursor Cluster-8309.6097 BP_3 11.95 0.52 1399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09514//PF01064 SSXRD motif//Activin types I and II receptor domain GO:0009069//GO:0016310//GO:0007178//GO:0006355 serine family amino acid metabolic process//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//regulation of transcription, DNA-templated GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.60976 BP_3 13.22 0.35 2123 546686878 ERL95889.1 161 3.0e-08 hypothetical protein D910_00548 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60977 BP_3 49.96 0.40 6361 478251376 ENN71842.1 192 2.3e-11 hypothetical protein YQE_11460, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00015//PF04687 Methyl-accepting chemotaxis protein (MCP) signalling domain//Microvirus H protein (pilot protein) GO:0046718//GO:0007165 viral entry into host cell//signal transduction GO:0004871 signal transducer activity GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-8309.60978 BP_3 44.05 1.16 2126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60980 BP_3 87.63 4.87 1159 642921434 XP_008192864.1 1308 1.6e-141 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P86410 518 2.7e-51 Ral GTPase-activating protein subunit beta OS=Rattus norvegicus GN=Ralgapb PE=1 SV=1 PF02145 Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.60981 BP_3 1.00 1.62 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60990 BP_3 3.00 0.31 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60999 BP_3 9.75 0.54 1168 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61 BP_3 1.00 0.32 440 321478070 EFX89028.1 490 4.3e-47 hypothetical protein DAPPUDRAFT_310889 [Daphnia pulex] -- -- -- -- -- K01556 KYNU, kynU kynureninase http://www.genome.jp/dbget-bin/www_bget?ko:K01556 Q9CXF0 411 2.6e-39 Kynureninase OS=Mus musculus GN=Kynu PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3846 L-kynurenine hydrolase Cluster-8309.610 BP_3 3.00 0.58 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04995//PF08655 Heme exporter protein D (CcmD)//DASH complex subunit Ask1 GO:0015886//GO:0017004//GO:0008608 heme transport//cytochrome complex assembly//attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729//GO:0016021 mitotic spindle//DASH complex//integral component of membrane -- -- Cluster-8309.6100 BP_3 30.20 0.49 3252 641660547 XP_008181531.1 770 1.1e-78 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04272//PF02944 Phospholamban//BESS motif GO:0006810//GO:0006816 transport//calcium ion transport GO:0042030//GO:0005246//GO:0003677 ATPase inhibitor activity//calcium channel regulator activity//DNA binding GO:0016020 membrane -- -- Cluster-8309.61008 BP_3 1.00 8.69 247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61009 BP_3 64.47 0.59 5565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6101 BP_3 3.00 0.99 437 641660547 XP_008181531.1 166 1.6e-09 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02727 Copper amine oxidase, N2 domain GO:0009308//GO:0055114 amine metabolic process//oxidation-reduction process GO:0048038//GO:0008131//GO:0005507 quinone binding//primary amine oxidase activity//copper ion binding -- -- -- -- Cluster-8309.61011 BP_3 24.00 1.09 1352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61015 BP_3 3.00 0.31 758 270015294 EFA11742.1 220 1.5e-15 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61018 BP_3 21.21 0.60 1997 478249887 ENN70394.1 825 2.8e-85 hypothetical protein YQE_12900, partial [Dendroctonus ponderosae]>gi|546683393|gb|ERL93212.1| hypothetical protein D910_10508 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BZD2 379 6.0e-35 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.61023 BP_3 9.00 0.87 792 315057121 ADT71676.1 594 6.8e-59 antilipopolysaccharide factor 2 [Scylla paramamosain] 315057120 HM345950.1 618 0 Scylla paramamosain antilipopolysaccharide factor 2 mRNA, complete cds -- -- -- -- C0KJQ4 185 7.5e-13 Anti-lipopolysaccharide factor OS=Portunus trituberculatus GN=ALF PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61025 BP_3 9.61 0.62 1040 861624759 KMQ88359.1 1183 4.5e-127 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P0CT40 380 2.4e-35 Transposon Tf2-9 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-9 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61028 BP_3 92.00 6.04 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61029 BP_3 283.46 7.55 2102 478258003 ENN78141.1 804 8.1e-83 hypothetical protein YQE_05295, partial [Dendroctonus ponderosae]>gi|546682503|gb|ERL92426.1| hypothetical protein D910_09740 [Dendroctonus ponderosae] -- -- -- -- -- K09537 DNAJC17 DnaJ homolog subfamily C member 17 http://www.genome.jp/dbget-bin/www_bget?ko:K09537 Q91WT4 513 1.8e-50 DnaJ homolog subfamily C member 17 OS=Mus musculus GN=Dnajc17 PE=2 SV=2 PF04111//PF00076 Autophagy protein Apg6//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006914 autophagy GO:0003676 nucleic acid binding -- -- KOG0691 Molecular chaperone (DnaJ superfamily) Cluster-8309.61034 BP_3 2.59 0.64 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61038 BP_3 15.00 0.66 1379 795010007 XP_011864749.1 482 1.2e-45 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.61042 BP_3 357.88 4.57 4063 478250336 ENN70833.1 1876 7.7e-207 hypothetical protein YQE_12497, partial [Dendroctonus ponderosae] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 571 6.7e-57 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61043 BP_3 5.00 0.61 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61046 BP_3 7.00 1.06 609 290563445 NP_001166691.1 340 1.5e-29 cuticular protein RR-2 motif 67 precursor [Bombyx mori]>gi|223671236|tpd|FAA00570.1| TPA: putative cuticle protein [Bombyx mori] 346714035 AK384563.1 81 2.47379e-32 Bombyx mori mRNA, clone: fcaL28D17_K03071 -- -- -- -- P80683 325 3.3e-29 Larval cuticle protein A3A OS=Tenebrio molitor PE=1 SV=1 PF06756//PF00379 Chorion protein S19 C-terminal//Insect cuticle protein GO:0007275 multicellular organismal development GO:0042302 structural constituent of cuticle GO:0042600 chorion -- -- Cluster-8309.61047 BP_3 3.00 0.42 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02820 mbt repeat GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.6105 BP_3 26.86 0.62 2394 91078782 XP_969464.1 965 2.0e-101 PREDICTED: differentially expressed in FDCP 8 homolog [Tribolium castaneum]>gi|270004105|gb|EFA00553.1| hypothetical protein TcasGA2_TC003420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZN54 563 3.3e-56 Differentially expressed in FDCP 8 homolog OS=Homo sapiens GN=DEF8 PE=1 SV=2 PF00684//PF00130//PF07649 DnaJ central domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0051082//GO:0008270//GO:0047134//GO:0046872//GO:0031072 unfolded protein binding//zinc ion binding//protein-disulfide reductase activity//metal ion binding//heat shock protein binding GO:0005622 intracellular KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.61053 BP_3 32.98 0.75 2406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61057 BP_3 25.59 1.36 1199 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61058 BP_3 3.00 1.03 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61059 BP_3 13.00 0.98 934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61066 BP_3 3.00 0.49 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61072 BP_3 37.33 0.67 2990 91079234 XP_970844.1 2430 3.3e-271 PREDICTED: TFIIH basal transcription factor complex helicase XPD subunit [Tribolium castaneum]>gi|270003570|gb|EFA00018.1| hypothetical protein TcasGA2_TC002825 [Tribolium castaneum] 805765990 XM_003700903.2 298 2.97987e-152 PREDICTED: Megachile rotundata TFIIH basal transcription factor complex helicase XPD subunit (LOC100879328), mRNA K10844 ERCC2, XPD DNA excision repair protein ERCC-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10844 A6QLJ0 1877 1.8e-208 TFIIH basal transcription factor complex helicase XPD subunit OS=Bos taurus GN=ERCC2 PE=2 SV=1 PF13307//PF16969//PF06777//PF06733//PF00270//PF01637//PF02562//PF04851//PF00176//PF00580 Helicase C-terminal domain//RNA-binding signal recognition particle 68//Helical and beta-bridge domain//DEAD_2//DEAD/DEAH box helicase//Archaeal ATPase//PhoH-like protein//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//UvrD/REP helicase N-terminal domain GO:0006289//GO:0006614//GO:0006139 nucleotide-excision repair//SRP-dependent cotranslational protein targeting to membrane//nucleobase-containing compound metabolic process GO:0003677//GO:0008026//GO:0008312//GO:0003676//GO:0030942//GO:0005524//GO:0016787//GO:0005047//GO:0004003//GO:0016818 DNA binding//ATP-dependent helicase activity//7S RNA binding//nucleic acid binding//endoplasmic reticulum signal peptide binding//ATP binding//hydrolase activity//signal recognition particle binding//ATP-dependent DNA helicase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005657//GO:0005634//GO:0005786 replication fork//nucleus//signal recognition particle, endoplasmic reticulum targeting KOG1131 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 Cluster-8309.61073 BP_3 27.40 0.65 2323 270014919 EFA11367.1 1082 5.2e-115 hypothetical protein TcasGA2_TC011524 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AIW0 245 2.4e-19 Serologically defined colon cancer antigen 3 homolog OS=Mus musculus GN=Sdccag3 PE=2 SV=1 PF01496//PF16716//PF04871//PF13851//PF16867//PF06009//PF06156//PF04111//PF01486//PF04632//PF00769//PF08702//PF02050//PF08352//PF10473 V-type ATPase 116kDa subunit family//Bone marrow stromal antigen 2//Uso1 / p115 like vesicle tethering protein, C terminal region//Growth-arrest specific micro-tubule binding//Dimethlysulfonioproprionate lyase//Laminin Domain II//Protein of unknown function (DUF972)//Autophagy protein Apg6//K-box region//Fusaric acid resistance protein family//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Flagellar FliJ protein//Oligopeptide/dipeptide transporter, C-terminal region//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0007155//GO:0015991//GO:0051607//GO:0015031//GO:0006355//GO:0006810//GO:0006886//GO:0006914//GO:0051258//GO:0007165//GO:0030168//GO:0048870//GO:0071973//GO:0006935//GO:0015992//GO:0006260//GO:0015833 cell adhesion//ATP hydrolysis coupled proton transport//defense response to virus//protein transport//regulation of transcription, DNA-templated//transport//intracellular protein transport//autophagy//protein polymerization//signal transduction//platelet activation//cell motility//bacterial-type flagellum-dependent cell motility//chemotaxis//proton transport//DNA replication//peptide transport GO:0042803//GO:0008565//GO:0015078//GO:0000166//GO:0003774//GO:0030674//GO:0008092//GO:0047869//GO:0003700//GO:0005102//GO:0045502//GO:0008134//GO:0005524 protein homodimerization activity//protein transporter activity//hydrogen ion transmembrane transporter activity//nucleotide binding//motor activity//protein binding, bridging//cytoskeletal protein binding//dimethylpropiothetin dethiomethylase activity//transcription factor activity, sequence-specific DNA binding//receptor binding//dynein binding//transcription factor binding//ATP binding GO:0033179//GO:0016020//GO:0005886//GO:0005634//GO:0005737//GO:0031514//GO:0005667//GO:0030286//GO:0005577//GO:0009288//GO:0019898 proton-transporting V-type ATPase, V0 domain//membrane//plasma membrane//nucleus//cytoplasm//motile cilium//transcription factor complex//dynein complex//fibrinogen complex//bacterial-type flagellum//extrinsic component of membrane -- -- Cluster-8309.61074 BP_3 404.36 3.71 5546 642923343 XP_008193710.1 3009 0.0e+00 PREDICTED: homeotic protein spalt-major-like isoform X1 [Tribolium castaneum]>gi|270008162|gb|EFA04610.1| spalt [Tribolium castaneum] 642923348 XM_008195491.1 157 1.33785e-73 PREDICTED: Tribolium castaneum homeotic protein spalt-major-like (LOC103313104), transcript variant X4, mRNA -- -- -- -- P39770 661 3.3e-67 Homeotic protein spalt-major OS=Drosophila melanogaster GN=salm PE=1 SV=3 PF13465//PF00096//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.61075 BP_3 13.07 0.36 2047 642910324 XP_008200283.1 793 1.5e-81 PREDICTED: serologically defined colon cancer antigen 3 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AIW0 138 5.4e-07 Serologically defined colon cancer antigen 3 homolog OS=Mus musculus GN=Sdccag3 PE=2 SV=1 PF05837//PF16867//PF04632//PF01496 Centromere protein H (CENP-H)//Dimethlysulfonioproprionate lyase//Fusaric acid resistance protein family//V-type ATPase 116kDa subunit family GO:0015992//GO:0015991//GO:0006810//GO:0051382 proton transport//ATP hydrolysis coupled proton transport//transport//kinetochore assembly GO:0047869//GO:0015078 dimethylpropiothetin dethiomethylase activity//hydrogen ion transmembrane transporter activity GO:0033179//GO:0000776//GO:0005886 proton-transporting V-type ATPase, V0 domain//kinetochore//plasma membrane -- -- Cluster-8309.61077 BP_3 234.68 2.09 5696 642923351 XP_008193714.1 3009 0.0e+00 PREDICTED: homeotic protein spalt-major-like isoform X4 [Tribolium castaneum] 642923348 XM_008195491.1 157 1.37427e-73 PREDICTED: Tribolium castaneum homeotic protein spalt-major-like (LOC103313104), transcript variant X4, mRNA -- -- -- -- P39770 661 3.4e-67 Homeotic protein spalt-major OS=Drosophila melanogaster GN=salm PE=1 SV=3 PF13465//PF00096//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.61078 BP_3 30.08 0.57 2815 642923343 XP_008193710.1 601 3.7e-59 PREDICTED: homeotic protein spalt-major-like isoform X1 [Tribolium castaneum]>gi|270008162|gb|EFA04610.1| spalt [Tribolium castaneum] 642923348 XM_008195491.1 157 6.74752e-74 PREDICTED: Tribolium castaneum homeotic protein spalt-major-like (LOC103313104), transcript variant X4, mRNA -- -- -- -- Q9ER74 139 5.7e-07 Sal-like protein 1 OS=Mus musculus GN=Sall1 PE=2 SV=1 -- -- -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.61081 BP_3 21.00 0.35 3215 674563875 CDS21559.1 332 6.6e-28 Serine:threonine protein kinase PLK4 [Echinococcus granulosus] 768311759 CP010987.1 3185 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O14328 600 2.3e-60 Serine/threonine-protein kinase ksp1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ksp1 PE=1 SV=1 PF06293//PF00069//PF16094//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Proteasome assembly chaperone 4//Protein tyrosine kinase GO:0006468//GO:0043248 protein phosphorylation//proteasome assembly GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0005783//GO:0016020 endoplasmic reticulum//membrane KOG0583 Serine/threonine protein kinase Cluster-8309.61084 BP_3 28.90 0.50 3069 534293303 AGU16824.1 1795 1.4e-197 S-adenosyl- L-homocysteine hydrolase [Leptinotarsa decemlineata]>gi|859132839|gb|AKO63328.1| S-adenosylhomocysteine hydrolase 2 [Leptinotarsa decemlineata] 850297653 XM_004707810.2 186 5.57336e-90 PREDICTED: Echinops telfairi adenosylhomocysteinase-like 2 (AHCYL2), mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 A6QLP2 1593 1.6e-175 Adenosylhomocysteinase 3 OS=Bos taurus GN=AHCYL2 PE=1 SV=1 PF07851//PF13241//PF07992//PF05221//PF02254//PF02882//PF02826 TMPIT-like protein//Putative NAD(P)-binding//Pyridine nucleotide-disulphide oxidoreductase//S-adenosyl-L-homocysteine hydrolase//TrkA-N domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006730//GO:0006779//GO:0006555//GO:0055114//GO:0019354//GO:0046487//GO:0009396//GO:0006813 one-carbon metabolic process//porphyrin-containing compound biosynthetic process//methionine metabolic process//oxidation-reduction process//siroheme biosynthetic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//potassium ion transport GO:0043115//GO:0003824//GO:0004488//GO:0016491//GO:0051287//GO:0004013 precorrin-2 dehydrogenase activity//catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity//NAD binding//adenosylhomocysteinase activity GO:0016021 integral component of membrane KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.61085 BP_3 30.71 1.32 1414 642929261 XP_008195760.1 268 7.7e-21 PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum]>gi|642929263|ref|XP_008195761.1| PREDICTED: uncharacterized protein LOC103313672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61089 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61090 BP_3 1.00 6.78 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61093 BP_3 2.00 0.81 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61094 BP_3 1.00 0.57 373 506968805 AGM32746.1 215 2.8e-15 elongation of very long chain fatty acids protein 4-like protein [Coptotermes formosanus] -- -- -- -- -- K10249 ELOVL4 elongation of very long chain fatty acids protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10249 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61103 BP_3 6.00 1.05 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61106 BP_3 32.61 0.97 1909 478261808 ENN80931.1 484 9.3e-46 hypothetical protein YQE_02637, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61117 BP_3 10.94 1.25 712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61118 BP_3 3.88 0.33 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61119 BP_3 14.16 0.36 2162 642933131 XP_008197270.1 655 1.6e-65 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] 462326012 APGK01041603.1 84 1.96624e-33 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- Q8N4B1 372 4.2e-34 Sesquipedalian-1 OS=Homo sapiens GN=FAM109A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61125 BP_3 21.42 1.26 1110 531446815 AGT57845.1 891 3.5e-93 cytochrome P450 334e3, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V6D6 234 2.2e-18 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.61126 BP_3 60.93 1.65 2076 642918821 XP_972786.2 797 5.2e-82 PREDICTED: TNF receptor-associated factor 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09596//PF02176//PF06009 MamL-1 domain//TRAF-type zinc finger//Laminin Domain II GO:0007219//GO:0007155//GO:0045944 Notch signaling pathway//cell adhesion//positive regulation of transcription from RNA polymerase II promoter GO:0003713//GO:0008270 transcription coactivator activity//zinc ion binding GO:0005667//GO:0016607 transcription factor complex//nuclear speck -- -- Cluster-8309.61127 BP_3 7.00 8.42 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61129 BP_3 1.00 0.33 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61130 BP_3 10.66 0.73 993 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61137 BP_3 24.40 0.41 3188 642921556 XP_008192422.1 1594 3.0e-174 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- K14616 CUBN cubilin http://www.genome.jp/dbget-bin/www_bget?ko:K14616 Q9TU53 1083 2.2e-116 Cubilin OS=Canis familiaris GN=CUBN PE=1 SV=1 PF00008//PF07645//PF05693 EGF-like domain//Calcium-binding EGF domain//Glycogen synthase GO:0005978//GO:0005985//GO:0005982 glycogen biosynthetic process//sucrose metabolic process//starch metabolic process GO:0005515//GO:0004373//GO:0005509 protein binding//glycogen (starch) synthase activity//calcium ion binding -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.61141 BP_3 120.57 7.69 1047 91086895 XP_970738.1 939 8.9e-99 PREDICTED: probable cytochrome P450 49a1 [Tribolium castaneum]>gi|270011073|gb|EFA07521.1| cytochrome P450 49A1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 626 7.2e-64 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0004497//GO:0020037//GO:0005506//GO:0016705//GO:0009055 monooxygenase activity//heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity -- -- -- -- Cluster-8309.61142 BP_3 196.45 1.36 7270 91086895 XP_970738.1 715 5.8e-72 PREDICTED: probable cytochrome P450 49a1 [Tribolium castaneum]>gi|270011073|gb|EFA07521.1| cytochrome P450 49A1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 550 3.3e-54 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0005506//GO:0004497//GO:0020037 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//monooxygenase activity//heme binding -- -- -- -- Cluster-8309.61147 BP_3 38.12 0.50 3989 642935200 XP_966348.3 1076 4.4e-114 PREDICTED: kelch-like ECH-associated protein 1 isoform X1 [Tribolium castaneum] 642935203 XM_008201467.1 145 4.49724e-67 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 599 3.7e-60 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF01344//PF07646//PF00651//PF03829 Kelch motif//Kelch motif//BTB/POZ domain//PTS system glucitol/sorbitol-specific IIA component GO:0009401//GO:0008643 phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport GO:0008982//GO:0005515 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein binding GO:0009357//GO:0005737 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//cytoplasm -- -- Cluster-8309.61149 BP_3 134.00 3.94 1929 642917419 XP_008191190.1 874 5.6e-91 PREDICTED: transcription factor Sox-9-B-like [Tribolium castaneum] 645010170 XM_008215211.1 71 2.95059e-26 PREDICTED: Nasonia vitripennis transcription factor SOX-9 (LOC100121308), transcript variant X2, mRNA K09270 SOX7S transcription factor SOX7/8/10/18 (SOX group E/F) http://www.genome.jp/dbget-bin/www_bget?ko:K09270 A5A763 458 4.0e-44 Transcription factor SOX-10 OS=Sus scrofa GN=SOX10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.61150 BP_3 18.04 0.37 2634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61152 BP_3 54.39 1.84 1719 270007077 EFA03525.1 1576 2.0e-172 hypothetical protein TcasGA2_TC013527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 546 2.2e-54 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61171 BP_3 69.84 1.23 3028 270003330 EEZ99777.1 1507 3.5e-164 hypothetical protein TcasGA2_TC002556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61173 BP_3 172.77 6.82 1512 478250370 ENN70865.1 1009 9.8e-107 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672860|gb|ERL84583.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 625 1.4e-63 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF00975//PF00326//PF07859//PF02230//PF01764 Thioesterase domain//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Lipase (class 3) GO:0006508//GO:0008152//GO:0009058//GO:0006629 proteolysis//metabolic process//biosynthetic process//lipid metabolic process GO:0016787//GO:0016788//GO:0008236 hydrolase activity//hydrolase activity, acting on ester bonds//serine-type peptidase activity -- -- -- -- Cluster-8309.61176 BP_3 586.84 11.13 2834 91079032 XP_974956.1 1427 6.2e-155 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270003667|gb|EFA00115.1| hypothetical protein TcasGA2_TC002931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 209 4.4e-15 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.61177 BP_3 229.10 4.28 2872 642918714 XP_008191551.1 1616 7.7e-177 PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|642918716|ref|XP_008191552.1| PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|270005665|gb|EFA02113.1| hypothetical protein TcasGA2_TC007759 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 P70496 674 5.4e-69 Phospholipase D1 OS=Rattus norvegicus GN=Pld1 PE=1 SV=3 PF02399//PF00787//PF00614 Origin of replication binding protein//PX domain//Phospholipase D Active site motif GO:0006260//GO:0007154//GO:0008152 DNA replication//cell communication//metabolic process GO:0003688//GO:0003824//GO:0005524//GO:0035091 DNA replication origin binding//catalytic activity//ATP binding//phosphatidylinositol binding GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.61180 BP_3 1.00 0.33 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61182 BP_3 7.00 0.48 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61187 BP_3 2512.76 4960.53 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83653 208 6.0e-16 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.61191 BP_3 97.38 2.28 2350 642934168 XP_008199635.1 1894 3.6e-209 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.70183e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 O95352 1300 1.1e-141 Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1 PF02826//PF00899//PF13241 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//ThiF family//Putative NAD(P)-binding GO:0055114//GO:0006779//GO:0019354 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process GO:0051287//GO:0008641//GO:0043115 NAD binding//small protein activating enzyme activity//precorrin-2 dehydrogenase activity -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.61195 BP_3 12.83 0.32 2226 478255200 ENN75429.1 447 2.1e-41 hypothetical protein YQE_07980, partial [Dendroctonus ponderosae]>gi|546684525|gb|ERL94156.1| hypothetical protein D910_11438 [Dendroctonus ponderosae] -- -- -- -- -- K10409 DNAI1 dynein intermediate chain 1, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10409 Q16959 275 7.7e-23 Dynein intermediate chain 2, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61196 BP_3 2.00 0.49 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61203 BP_3 8.00 3.55 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61208 BP_3 40.15 0.75 2875 260781332 XP_002585771.1 633 7.4e-63 hypothetical protein BRAFLDRAFT_257357 [Branchiostoma floridae]>gi|229270812|gb|EEN41782.1| hypothetical protein BRAFLDRAFT_257357, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- A6NN14 429 1.4e-40 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF00096//PF13465//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.61214 BP_3 3.06 0.92 451 478256683 ENN76865.1 153 5.3e-08 hypothetical protein YQE_06706, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61215 BP_3 52.46 1.20 2401 91087699 XP_974256.1 900 6.8e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 4.7e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.61216 BP_3 15.00 1.19 899 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61217 BP_3 3.00 0.78 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61222 BP_3 9.11 0.33 1607 642919727 XP_970439.2 145 1.6e-06 PREDICTED: guanylate cyclase soluble subunit beta-1 [Tribolium castaneum]>gi|642919729|ref|XP_008192041.1| PREDICTED: guanylate cyclase soluble subunit beta-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61226 BP_3 20.00 0.40 2721 646710887 KDR16277.1 1333 4.8e-144 Myosin-XVIIIa, partial [Zootermopsis nevadensis] -- -- -- -- -- K10362 MYO18 myosin XVIII http://www.genome.jp/dbget-bin/www_bget?ko:K10362 Q9JMH9 958 6.0e-102 Unconventional myosin-XVIIIa OS=Mus musculus GN=Myo18a PE=1 SV=2 PF01576 Myosin tail -- -- GO:0003774 motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.61228 BP_3 15.71 0.47 1896 642925409 XP_008194539.1 803 9.5e-83 PREDICTED: anoctamin-4-like [Tribolium castaneum]>gi|270008794|gb|EFA05242.1| hypothetical protein TcasGA2_TC015391 [Tribolium castaneum] -- -- -- -- -- K19480 ANO5, GDD1, TMEM16E anoctamin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K19480 Q75V66 222 9.2e-17 Anoctamin-5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0006821//GO:0006820 chloride transport//anion transport GO:0046983//GO:0005254 protein dimerization activity//chloride channel activity GO:0034707 chloride channel complex -- -- Cluster-8309.61229 BP_3 26.26 0.71 2073 242012953 XP_002427188.1 625 4.5e-62 conserved hypothetical protein [Pediculus humanus corporis]>gi|212511475|gb|EEB14450.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61233 BP_3 81.00 2.68 1749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61234 BP_3 119.00 3.36 1999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61245 BP_3 15.12 1.06 980 546682632 ERL92547.1 148 4.4e-07 hypothetical protein D910_09860 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61249 BP_3 60.05 6.34 748 642937546 XP_008199090.1 610 9.0e-61 PREDICTED: transmembrane protein C5orf28 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DC75 275 2.6e-23 Transmembrane protein C5orf28 homolog OS=Danio rerio GN=si:busm1-79m10.4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61255 BP_3 3.11 0.52 581 91087039 XP_974482.1 675 2.0e-68 PREDICTED: AP-3 complex subunit sigma-2 isoform X1 [Tribolium castaneum]>gi|270009628|gb|EFA06076.1| hypothetical protein TcasGA2_TC008912 [Tribolium castaneum] 505849574 XM_004618186.1 79 3.04422e-31 PREDICTED: Sorex araneus adaptor-related protein complex 3, sigma 1 subunit (AP3S1), mRNA K12399 AP3S AP-3 complex subunit sigma http://www.genome.jp/dbget-bin/www_bget?ko:K12399 P59780 617 4.4e-63 AP-3 complex subunit sigma-2 OS=Homo sapiens GN=AP3S2 PE=1 SV=1 -- -- GO:0006886//GO:0016192//GO:0015031 intracellular protein transport//vesicle-mediated transport//protein transport GO:0008565 protein transporter activity GO:0030117 membrane coat KOG0936 Clathrin adaptor complex, small subunit Cluster-8309.61257 BP_3 11.01 0.36 1752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04614 Pex19 protein family -- -- -- -- GO:0005777 peroxisome -- -- Cluster-8309.61261 BP_3 16.00 1.81 718 478249453 ENN70175.1 162 7.6e-09 hypothetical protein YQE_00015 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61267 BP_3 2.00 0.34 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61276 BP_3 17.00 0.66 1528 751234819 XP_011171162.1 373 5.6e-33 PREDICTED: uncharacterized protein LOC105203928 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61281 BP_3 18.00 0.54 1897 768425026 XP_011553490.1 530 4.3e-51 PREDICTED: uncharacterized protein LOC105384900 isoform X1 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61291 BP_3 184.29 3.36 2935 642934576 XP_008197723.1 473 2.7e-44 PREDICTED: uncharacterized protein LOC100142621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61292 BP_3 27.86 2.48 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00178//PF03574 Ets-domain//Peptidase family S48 GO:0043158//GO:0006355 heterocyst differentiation//regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700//GO:0004252 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//serine-type endopeptidase activity GO:0005667 transcription factor complex -- -- Cluster-8309.61293 BP_3 5.00 15.60 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61295 BP_3 14.75 0.32 2540 478254955 ENN75188.1 1076 2.8e-114 hypothetical protein YQE_08199, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6130 BP_3 247.00 2.94 4335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61301 BP_3 12.57 0.97 917 646707017 KDR13951.1 160 1.7e-08 FCH domain only protein 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q3UQN2 138 2.4e-07 F-BAR domain only protein 2 OS=Mus musculus GN=Fcho2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61303 BP_3 57.00 0.98 3101 642914709 XP_008199908.1 479 5.8e-45 PREDICTED: protein slit-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 220 2.6e-16 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.61306 BP_3 33.00 0.58 3014 270015833 EFA12281.1 985 1.2e-103 hypothetical protein TcasGA2_TC005266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 269 5.2e-22 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00907//PF00665 T-box//Integrase core domain GO:0006355//GO:0015074 regulation of transcription, DNA-templated//DNA integration GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.61311 BP_3 1.00 0.31 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61312 BP_3 102.69 2.68 2136 332374612 AEE62447.1 1251 1.2e-134 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q52KD1 756 1.2e-78 Sodium/bile acid cotransporter 7-B OS=Xenopus laevis GN=slc10a7-b PE=2 SV=1 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.61319 BP_3 3.00 0.52 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61326 BP_3 4.00 0.42 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61331 BP_3 32.18 1.33 1459 531446199 AGT57842.1 917 4.4e-96 cytochrome P450 302a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10721 DIB CYP302A1; ecdysteroid 22-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10721 Q9NGX9 580 2.2e-58 Cytochrome P450 302a1, mitochondrial OS=Drosophila melanogaster GN=dib PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.61350 BP_3 9.00 0.36 1509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61353 BP_3 2.00 1.01 385 91083481 XP_971741.1 157 1.6e-08 PREDICTED: probable ATP-dependent RNA helicase spindle-E [Tribolium castaneum]>gi|270011114|gb|EFA07562.1| spindle E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005488 binding -- -- -- -- Cluster-8309.61357 BP_3 1.00 2.02 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61358 BP_3 61.44 1.28 2607 282721120 NP_001164234.1 568 2.3e-55 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17951 CYP27C cytochrome P450, family 27, subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K17951 Q9V6D6 382 3.5e-35 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0016705//GO:0009055//GO:0020037//GO:0004497//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity//heme binding//monooxygenase activity//iron ion binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.61361 BP_3 182.53 12.40 1001 642935674 XP_974741.2 521 2.5e-50 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9S1 415 2.0e-39 Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Drosophila melanogaster GN=blos1 PE=1 SV=2 PF06151//PF06320 Trehalose receptor//GCN5-like protein 1 (GCN5L1) GO:0007607//GO:0007187//GO:0050912 obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste GO:0008527 taste receptor activity GO:0031083//GO:0016021 BLOC-1 complex//integral component of membrane KOG3390 General control of amino-acid synthesis 5-like 1 Cluster-8309.61368 BP_3 29.03 0.55 2826 546679503 ERL89962.1 1411 4.5e-153 hypothetical protein D910_07321 [Dendroctonus ponderosae] -- -- -- -- -- K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 Q9ULJ8 575 1.6e-57 Neurabin-1 OS=Homo sapiens GN=PPP1R9A PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.6137 BP_3 3.92 1.24 444 642931926 XP_008196783.1 486 1.3e-46 PREDICTED: uncharacterized protein LOC103313947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61371 BP_3 26.00 0.42 3300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01408 Oxidoreductase family, NAD-binding Rossmann fold -- -- GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.61378 BP_3 20.19 0.49 2259 861611749 KMQ85356.1 837 1.3e-86 rna-directed dna polymerase from mobile element jockey-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- P21328 311 5.2e-27 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila melanogaster GN=pol PE=1 SV=1 PF07819 PGAP1-like protein GO:0006505//GO:0006886 GPI anchor metabolic process//intracellular protein transport GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.61379 BP_3 8.00 0.74 813 662216874 XP_008482393.1 239 1.0e-17 PREDICTED: uncharacterized protein LOC103519090 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61381 BP_3 17.48 0.75 1418 134031943 NP_001076796.1 790 2.3e-81 cardioacceleratory peptide receptor 1 [Tribolium castaneum]>gi|126116538|gb|ABN79651.1| cardioactive peptide receptor 1 [Tribolium castaneum]>gi|270012688|gb|EFA09136.1| hypothetical protein TcasGA2_TC002216 [Tribolium castaneum]>gi|485836800|tpg|DAA64485.1| TPA_inf: CCAP-like G protein-coupled receptor 2 [Tribolium castaneum] -- -- -- -- -- K08376 NPSR1, GPR154 neuropeptide S receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08376 Q868T3 648 2.7e-66 Cardioacceleratory peptide receptor OS=Drosophila melanogaster GN=CCAP-R PE=2 SV=3 PF02118//PF00001 Srg family chemoreceptor//7 transmembrane receptor (rhodopsin family) GO:0007165//GO:0007187//GO:0007186//GO:0007606 signal transduction//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus GO:0004930//GO:0004888//GO:0005000 G-protein coupled receptor activity//transmembrane signaling receptor activity//vasopressin receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.61385 BP_3 101.21 3.38 1735 260841501 XP_002613951.1 328 1.0e-27 hypothetical protein BRAFLDRAFT_67486 [Branchiostoma floridae]>gi|229299341|gb|EEN69960.1| hypothetical protein BRAFLDRAFT_67486 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NN14 308 8.9e-27 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF00096//PF13465//PF13912//PF15926//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//E3 ubiquitin-protein ligase RNF220//Zinc-finger associated domain (zf-AD) GO:0016567//GO:0090263 protein ubiquitination//positive regulation of canonical Wnt signaling pathway GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.61392 BP_3 2.00 1.04 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61398 BP_3 269.35 4.44 3213 642910641 XP_008200040.1 2497 6.0e-279 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 518 0 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q7Z6J6 772 2.6e-80 FERM domain-containing protein 5 OS=Homo sapiens GN=FRMD5 PE=1 SV=1 PF15168 Triple QxxK/R motif-containing protein family -- -- GO:0008092 cytoskeletal protein binding GO:0005856//GO:0005789//GO:0019898//GO:0005737 cytoskeleton//endoplasmic reticulum membrane//extrinsic component of membrane//cytoplasm KOG3530 FERM domain protein EHM2 Cluster-8309.61399 BP_3 34.47 0.49 3700 642910641 XP_008200040.1 1253 1.2e-134 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 134 5.43051e-61 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q5R803 630 8.8e-64 FERM domain-containing protein 3 OS=Pongo abelii GN=FRMD3 PE=2 SV=1 PF00335//PF01676 Tetraspanin family//Metalloenzyme superfamily -- -- GO:0046872//GO:0008092//GO:0003824 metal ion binding//cytoskeletal protein binding//catalytic activity GO:0005737//GO:0005856//GO:0016021//GO:0019898 cytoplasm//cytoskeleton//integral component of membrane//extrinsic component of membrane KOG3530 FERM domain protein EHM2 Cluster-8309.6140 BP_3 28969.70 746.19 2163 478252248 ENN72676.1 1436 4.3e-156 hypothetical protein YQE_10774, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI17 1324 1.7e-144 Protein yellow OS=Drosophila yakuba GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61401 BP_3 15.44 0.35 2448 861610178 KMQ85078.1 798 4.7e-82 dna-mediated transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03554//PF01136 UL73 viral envelope glycoprotein//Peptidase family U32 GO:0006508 proteolysis GO:0008233 peptidase activity GO:0019031 viral envelope -- -- Cluster-8309.61402 BP_3 160.78 4.48 2021 332375110 AEE62696.1 1882 7.7e-208 unknown [Dendroctonus ponderosae]>gi|478257862|gb|ENN78004.1| hypothetical protein YQE_05524, partial [Dendroctonus ponderosae]>gi|546674573|gb|ERL85926.1| hypothetical protein D910_03341 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VCA2 693 2.4e-71 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.61404 BP_3 498.00 10.53 2572 642919781 XP_008192063.1 1066 4.1e-113 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61406 BP_3 55.54 7.94 629 642929003 XP_973340.3 387 5.4e-35 PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|642929005|ref|XP_008195651.1| PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum] 642929004 XM_008197429.1 40 1.58484e-09 PREDICTED: Tribolium castaneum alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC662130), transcript variant X2, mRNA -- -- -- -- P27808 132 8.3e-07 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat1 PE=2 SV=1 PF03071 GNT-I family GO:0006486 protein glycosylation GO:0008375 acetylglucosaminyltransferase activity -- -- KOG1413 N-acetylglucosaminyltransferase I Cluster-8309.61408 BP_3 34.81 0.41 4392 189234308 XP_971839.2 1959 2.0e-216 PREDICTED: solute carrier family 35 member F3 [Tribolium castaneum] -- -- -- -- -- K15288 SLC35F3_4 solute carrier family 35, member F3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15288 Q1LZI2 549 2.6e-54 Putative thiamine transporter SLC35F3 OS=Mus musculus GN=Slc35f3 PE=2 SV=1 PF06027//PF00892 Solute carrier family 35//EamA-like transporter family GO:0006810 transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4314 Predicted carbohydrate/phosphate translocator Cluster-8309.6141 BP_3 670.36 12.15 2950 478252248 ENN72676.1 1234 1.6e-132 hypothetical protein YQE_10774, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI17 1151 2.7e-124 Protein yellow OS=Drosophila yakuba GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61410 BP_3 3.00 0.48 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61411 BP_3 59.96 2.21 1599 531444638 AGT57836.1 748 1.9e-76 cytochrome P450 412a1 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P29981 601 8.7e-61 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.61412 BP_3 124.00 4.01 1783 189241899 XP_967370.2 347 6.7e-30 PREDICTED: TP53-regulated inhibitor of apoptosis 1-like [Tribolium castaneum] -- -- -- -- -- K17968 TRIAP1, MDM35 TRIAP1/MDM35 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K17968 O43715 224 5.1e-17 TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens GN=TRIAP1 PE=1 SV=1 PF11093//PF05051 Mitochondrial export protein Som1//Cytochrome C oxidase copper chaperone (COX17) GO:0006825 copper ion transport GO:0016531//GO:0005507 copper chaperone activity//copper ion binding GO:0005758//GO:0042720 mitochondrial intermembrane space//mitochondrial inner membrane peptidase complex KOG3481 Uncharacterized conserved protein Cluster-8309.61415 BP_3 63.00 5.21 875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61416 BP_3 29.00 0.80 2049 642932676 XP_008196940.1 335 1.9e-28 PREDICTED: uncharacterized protein LOC103314013 [Tribolium castaneum]>gi|642932678|ref|XP_008196941.1| PREDICTED: uncharacterized protein LOC103314013 [Tribolium castaneum]>gi|270011528|gb|EFA07976.1| hypothetical protein TcasGA2_TC005558 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q802Y8 148 3.8e-08 Zinc finger and BTB domain-containing protein 16-A OS=Danio rerio GN=zbtb16a PE=1 SV=1 PF06467//PF05191//PF01155//PF00096 MYM-type Zinc finger with FCS sequence motif//Adenylate kinase, active site lid//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type GO:0006464//GO:0006144//GO:0046034 cellular protein modification process//purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0004017//GO:0046872//GO:0016151 zinc ion binding//adenylate kinase activity//metal ion binding//nickel cation binding -- -- -- -- Cluster-8309.61419 BP_3 106.00 4.11 1536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6142 BP_3 176.00 7.19 1471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61420 BP_3 9.11 0.31 1703 642920283 XP_008192282.1 1741 1.5e-191 PREDICTED: DNA-directed RNA polymerase III subunit RPC3 [Tribolium castaneum]>gi|270006046|gb|EFA02494.1| hypothetical protein TcasGA2_TC008189 [Tribolium castaneum] -- -- -- -- -- K03023 RPC3, POLR3C DNA-directed RNA polymerase III subunit RPC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03023 Q9BUI4 786 3.3e-82 DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens GN=POLR3C PE=1 SV=1 PF05645 RNA polymerase III subunit RPC82 GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG2587 RNA polymerase III (C) subunit Cluster-8309.61421 BP_3 27.49 0.31 4522 859132821 AKO63322.1 1175 1.7e-125 diphosphomevalonate decarboxylase [Leptinotarsa decemlineata] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 893 3.4e-94 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 PF04627 Mitochondrial ATP synthase epsilon chain GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.61423 BP_3 66.45 2.25 1716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61428 BP_3 70.00 15.81 505 156553793 XP_001599584.1 629 3.8e-63 PREDICTED: PHD finger-like domain-containing protein 5A [Nasonia vitripennis]>gi|242012971|ref|XP_002427197.1| conserved hypothetical protein [Pediculus humanus corporis]>gi|350395948|ref|XP_003484388.1| PREDICTED: PHD finger-like domain-containing protein 5A [Bombus impatiens]>gi|383850892|ref|XP_003701008.1| PREDICTED: PHD finger-like domain-containing protein 5A [Megachile rotundata]>gi|572316493|ref|XP_006623871.1| PREDICTED: PHD finger-like domain-containing protein 5A-like [Apis dorsata]>gi|746835611|ref|XP_011068502.1| PREDICTED: PHD finger-like domain-containing protein 5A [Acromyrmex echinatior]>gi|749731248|ref|XP_011154391.1| PREDICTED: PHD finger-like domain-containing protein 5A [Harpegnathos saltator]>gi|751223018|ref|XP_011164776.1| PREDICTED: PHD finger-like domain-containing protein 5A [Solenopsis invicta]>gi|752889222|ref|XP_011262550.1| PREDICTED: PHD finger-like domain-containing protein 5A [Camponotus floridanus]>gi|755937688|ref|XP_011297178.1| PREDICTED: PHD finger-like domain-containing protein 5A [Fopius arisanus]>gi|759034616|ref|XP_011334720.1| PREDICTED: PHD finger-like domain-containing protein 5A [Cerapachys biroi]>gi|766923445|ref|XP_011506347.1| PREDICTED: PHD finger-like domain-containing protein 5A [Ceratosolen solmsi marchali]>gi|766923447|ref|XP_011506348.1| PREDICTED: PHD finger-like domain-containing protein 5A [Ceratosolen solmsi marchali]>gi|769854150|ref|XP_011638597.1| PREDICTED: PHD finger-like domain-containing protein 5A isoform X2 [Pogonomyrmex barbatus]>gi|780633537|ref|XP_011686073.1| PREDICTED: PHD finger-like domain-containing protein 5A [Wasmannia auropunctata]>gi|795007852|ref|XP_011858255.1| PREDICTED: PHD finger-like domain-containing protein 5A [Vollenhovia emeryi]>gi|801393085|ref|XP_012058015.1| PREDICTED: PHD finger-like domain-containing protein 5A [Atta cephalotes]>gi|805766705|ref|XP_012135327.1| PREDICTED: PHD finger-like domain-containing protein 5A [Megachile rotundata]>gi|805766713|ref|XP_012135328.1| PREDICTED: PHD finger-like domain-containing protein 5A [Megachile rotundata]>gi|815802989|ref|XP_012222185.1| PREDICTED: PHD finger-like domain-containing protein 5A [Linepithema humile]>gi|817053427|ref|XP_012261946.1| PREDICTED: PHD finger-like domain-containing protein 5A [Athalia rosae]>gi|817195171|ref|XP_012273120.1| PREDICTED: PHD finger-like domain-containing protein 5A [Orussus abietinus]>gi|826422980|ref|XP_012526512.1| PREDICTED: PHD finger-like domain-containing protein 5A [Monomorium pharaonis]>gi|212511484|gb|EEB14459.1| conserved hypothetical protein [Pediculus humanus corporis]>gi|307172921|gb|EFN64088.1| PHD finger-like domain-containing protein 5A [Camponotus floridanus]>gi|307215185|gb|EFN89957.1| PHD finger-like domain-containing protein 5A [Harpegnathos saltator]>gi|322789761|gb|EFZ14927.1| hypothetical protein SINV_12202, partial [Solenopsis invicta]>gi|332029661|gb|EGI69550.1| PHD finger-like domain-containing protein 5A [Acromyrmex echinatior]>gi|607368266|gb|EZA62380.1| PHD finger-like domain-containing protein 5A [Cerapachys biroi]>gi|646709736|gb|KDR15457.1| PHD finger-like domain-containing protein 5A [Zootermopsis nevadensis]>gi|861638037|gb|KMQ92354.1| phd finger-like domain-containing protein 5a protein [Lasius niger] 572316492 XM_006623808.1 161 6.85518e-77 PREDICTED: Apis dorsata PHD finger-like domain-containing protein 5A-like (LOC102675932), mRNA K12834 PHF5A PHD finger-like domain-containing protein 5A http://www.genome.jp/dbget-bin/www_bget?ko:K12834 Q7RTV0 618 2.9e-63 PHD finger-like domain-containing protein 5A OS=Homo sapiens GN=PHF5A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1705 Uncharacterized conserved protein, contains CXXC motifs Cluster-8309.61437 BP_3 54.79 1.41 2159 642913117 XP_008201398.1 1589 7.8e-174 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.5e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61439 BP_3 21.00 0.68 1791 642926791 XP_008195017.1 245 4.5e-18 PREDICTED: uncharacterized protein LOC103313467 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00157//PF17064//PF02778 Pou domain - N-terminal to homeobox domain//Sleepless protein//tRNA intron endonuclease, N-terminal domain GO:0051252//GO:1903818//GO:0030431//GO:0006355//GO:0032222//GO:0006388 regulation of RNA metabolic process//positive regulation of voltage-gated potassium channel activity//sleep//regulation of transcription, DNA-templated//regulation of synaptic transmission, cholinergic//tRNA splicing, via endonucleolytic cleavage and ligation GO:0003700//GO:0000213//GO:0034235 transcription factor activity, sequence-specific DNA binding//tRNA-intron endonuclease activity//GPI anchor binding GO:0000214//GO:0005667 tRNA-intron endonuclease complex//transcription factor complex -- -- Cluster-8309.61441 BP_3 16.89 1.13 1009 641663663 XP_008182723.1 955 1.2e-100 PREDICTED: uncharacterized protein LOC103309327 [Acyrthosiphon pisum]>gi|641679805|ref|XP_008188719.1| PREDICTED: uncharacterized protein LOC103310986 [Acyrthosiphon pisum] 641663662 XM_008184501.1 537 0 PREDICTED: Acyrthosiphon pisum uncharacterized LOC103309327 (LOC103309327), mRNA >gnl|BL_ORD_ID|19443021 PREDICTED: Acyrthosiphon pisum uncharacterized LOC103310986 (LOC103310986), mRNA -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.61446 BP_3 4.73 0.39 877 642921217 XP_008192768.1 285 5.1e-23 PREDICTED: uncharacterized protein LOC656848 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5Y4U4 138 2.3e-07 U8-agatoxin-Ao1a OS=Agelena orientalis PE=2 SV=1 PF02819//PF02950//PF05039 Spider toxin//Conotoxin//Agouti protein GO:0006810//GO:0009405//GO:0009755 transport//pathogenesis//hormone-mediated signaling pathway GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.61447 BP_3 2.00 0.37 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61448 BP_3 35.52 0.75 2569 642910817 XP_008193421.1 1095 1.8e-116 PREDICTED: rab11 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 1.0e-26 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61456 BP_3 9.00 0.31 1682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61457 BP_3 67.85 3.04 1367 374842188 AEL33282.2 1748 1.8e-192 opsin protein [Charybdis japonica] 374842187 HQ856837.2 963 0 Charybdis japonica opsin protein mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25158 1704 9.4e-189 Compound eye opsin BCRH2 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.61459 BP_3 4.00 1.39 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6146 BP_3 8.00 1.30 588 642929346 XP_008195796.1 253 1.8e-19 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 [Tribolium castaneum]>gi|270009635|gb|EFA06083.1| hypothetical protein TcasGA2_TC008920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04648 Yeast mating factor alpha hormone GO:0019953//GO:0007165 sexual reproduction//signal transduction GO:0000772 mating pheromone activity GO:0005576 extracellular region -- -- Cluster-8309.61461 BP_3 669.34 5.34 6332 646720734 KDR22356.1 2695 1.3e-301 Protein melted [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9VS24 2301 2.6e-257 Protein melted OS=Drosophila melanogaster GN=melt PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3723 PH domain protein Melted Cluster-8309.61463 BP_3 7.31 0.38 1216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61465 BP_3 8.94 0.39 1385 642923681 XP_008193839.1 199 7.6e-13 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X1 [Tribolium castaneum]>gi|642923683|ref|XP_008193840.1| PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61470 BP_3 12.11 0.76 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61472 BP_3 3.21 0.34 749 820839747 XP_012350813.1 424 3.3e-39 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 isoform X2 [Apis florea]>gi|820839749|ref|XP_012350814.1| PREDICTED: elongation of very long chain fatty acids protein AAEL008004 isoform X2 [Apis florea] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 392 7.0e-37 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.61476 BP_3 122.42 3.12 2186 270007333 EFA03781.1 477 6.9e-45 hypothetical protein TcasGA2_TC013892 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61478 BP_3 9.95 1.23 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61479 BP_3 2.18 0.36 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6148 BP_3 37.00 0.45 4253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61480 BP_3 67.82 11.30 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61482 BP_3 282.10 7.45 2116 642927602 XP_008195330.1 594 1.8e-58 PREDICTED: uncharacterized protein LOC662018 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.61485 BP_3 51.78 2.10 1479 642914621 XP_008190287.1 330 5.2e-28 PREDICTED: uncharacterized protein LOC103312158 [Tribolium castaneum]>gi|270002271|gb|EEZ98718.1| hypothetical protein TcasGA2_TC001264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14833//PF01450 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//Acetohydroxy acid isomeroreductase, catalytic domain GO:0009099//GO:0055114//GO:0009082//GO:0015940//GO:0009098//GO:0009097 valine biosynthetic process//oxidation-reduction process//branched-chain amino acid biosynthetic process//pantothenate biosynthetic process//leucine biosynthetic process//isoleucine biosynthetic process GO:0004455//GO:0051287 ketol-acid reductoisomerase activity//NAD binding -- -- -- -- Cluster-8309.61488 BP_3 26.67 0.83 1848 667281488 XP_008574444.1 798 3.5e-82 PREDICTED: zinc finger protein 778-like [Galeopterus variegatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 767 5.7e-80 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF07776//PF00935//PF13912//PF01155//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Ribosomal protein L44//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-finger double domain//Zinc finger, C2H2 type GO:0042254//GO:0006412//GO:0006464 ribosome biogenesis//translation//cellular protein modification process GO:0046872//GO:0008270//GO:0003735//GO:0016151 metal ion binding//zinc ion binding//structural constituent of ribosome//nickel cation binding GO:0005840//GO:0005622//GO:0005634 ribosome//intracellular//nucleus -- -- Cluster-8309.61489 BP_3 35.20 0.34 5324 642927459 XP_968905.2 1082 1.2e-114 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q9EQZ5 783 2.3e-81 Prostaglandin reductase 1 OS=Cavia porcellus GN=Ptgr1 PE=1 SV=1 PF01118//PF01083//PF00107 Semialdehyde dehydrogenase, NAD binding domain//Cutinase//Zinc-binding dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016787//GO:0016620//GO:0051287 hydrolase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- -- -- Cluster-8309.61491 BP_3 5.00 1.63 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61493 BP_3 76.44 2.13 2020 91079362 XP_970302.1 1401 4.6e-152 PREDICTED: islet cell autoantigen 1 [Tribolium castaneum]>gi|270003491|gb|EEZ99938.1| hypothetical protein TcasGA2_TC002734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63054 650 2.3e-66 Islet cell autoantigen 1 OS=Rattus norvegicus GN=Ica1 PE=2 SV=2 PF06456 Arfaptin-like domain -- -- GO:0019904 protein domain specific binding -- -- KOG3891 Secretory vesicle-associated protein ICA69, contains Arfaptin domain Cluster-8309.61498 BP_3 6.00 1.55 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.615 BP_3 7.00 0.61 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61502 BP_3 1072.40 7.85 6877 91086895 XP_970738.1 830 2.5e-85 PREDICTED: probable cytochrome P450 49a1 [Tribolium castaneum]>gi|270011073|gb|EFA07521.1| cytochrome P450 49A1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 673 1.7e-68 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0004497//GO:0020037//GO:0005506//GO:0009055//GO:0016705 monooxygenase activity//heme binding//iron ion binding//electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.61503 BP_3 867.36 53.10 1079 91086895 XP_970738.1 1414 7.6e-154 PREDICTED: probable cytochrome P450 49a1 [Tribolium castaneum]>gi|270011073|gb|EFA07521.1| cytochrome P450 49A1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 1018 2.6e-109 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0005506//GO:0004497//GO:0020037//GO:0009055//GO:0016705 iron ion binding//monooxygenase activity//heme binding//electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.61508 BP_3 14.00 0.44 1835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01125 G10 protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.61509 BP_3 59.00 0.83 3706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61516 BP_3 136.00 2.92 2534 478263147 ENN81540.1 1450 1.2e-157 hypothetical protein YQE_02069, partial [Dendroctonus ponderosae]>gi|546681780|gb|ERL91806.1| hypothetical protein D910_09131 [Dendroctonus ponderosae] -- -- -- -- -- K02213 CDC6 cell division control protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02213 Q99741 852 1.1e-89 Cell division control protein 6 homolog OS=Homo sapiens GN=CDC6 PE=1 SV=1 PF03969//PF01637//PF00004//PF00437//PF14532//PF07728//PF05496//PF00158 AFG1-like ATPase//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain GO:0006810//GO:0006281//GO:0006355//GO:0006310 transport//DNA repair//regulation of transcription, DNA-templated//DNA recombination GO:0008134//GO:0005524//GO:0009378//GO:0016887 transcription factor binding//ATP binding//four-way junction helicase activity//ATPase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase Cluster-8309.61517 BP_3 23.04 0.37 3324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15247//PF05053 Histone RNA hairpin-binding protein RNA-binding domain//Menin -- -- GO:0003723 RNA binding GO:0005634 nucleus -- -- Cluster-8309.61519 BP_3 10.63 0.36 1731 642937892 XP_008200345.1 239 2.2e-17 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q29L39 171 6.9e-11 Protein purity of essence OS=Drosophila pseudoobscura pseudoobscura GN=poe PE=3 SV=1 PF01667//PF01119 Ribosomal protein S27//DNA mismatch repair protein, C-terminal domain GO:0042254//GO:0006412//GO:0006298 ribosome biogenesis//translation//mismatch repair GO:0003735//GO:0030983//GO:0005524 structural constituent of ribosome//mismatched DNA binding//ATP binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.61520 BP_3 1.00 10.88 241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61521 BP_3 10.00 0.50 1260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61523 BP_3 1.00 2.40 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61526 BP_3 258.55 3.45 3902 642925330 XP_008194509.1 2130 2.6e-236 PREDICTED: codanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CC12 901 3.5e-95 Codanin-1 OS=Mus musculus GN=Cdan1 PE=2 SV=2 PF12920 TcdA/TcdB pore forming domain GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.61528 BP_3 2.00 0.47 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61529 BP_3 2.00 0.32 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61530 BP_3 9.22 0.68 947 642918135 XP_008194136.1 310 6.9e-26 PREDICTED: WD repeat-containing protein 13-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H1Z4 141 1.1e-07 WD repeat-containing protein 13 OS=Homo sapiens GN=WDR13 PE=1 SV=2 PF05405 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- -- -- Cluster-8309.61531 BP_3 1.00 3.30 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61535 BP_3 335.33 4.35 4009 805775098 XP_012137658.1 3421 0.0e+00 PREDICTED: DNA (cytosine-5)-methyltransferase PliMCI-like [Megachile rotundata] 641648189 XM_008183068.1 77 2.85844e-29 PREDICTED: Acyrthosiphon pisum DNA (cytosine-5)-methyltransferase PliMCI-like (LOC103308886), mRNA K00558 DNMT1, dcm DNA (cytosine-5)-methyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00558 Q24K09 3068 0.0e+00 DNA (cytosine-5)-methyltransferase 1 OS=Bos taurus GN=DNMT1 PE=2 SV=1 PF02008//PF07542//PF01426 CXXC zinc finger domain//ATP12 chaperone protein//BAH domain GO:0043461 proton-transporting ATP synthase complex assembly GO:0008270//GO:0003677//GO:0003682 zinc ion binding//DNA binding//chromatin binding GO:0000785 chromatin -- -- Cluster-8309.61543 BP_3 6.77 0.40 1106 270015858 EFA12306.1 811 6.5e-84 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21329 284 3.5e-24 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila funebris GN=jockey\pol PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61544 BP_3 3.00 1.06 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61557 BP_3 31.45 1.75 1160 270013152 EFA09600.1 854 7.1e-89 hypothetical protein TcasGA2_TC011720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B91 316 7.1e-28 Protein tincar OS=Drosophila melanogaster GN=tinc PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61559 BP_3 124.25 1.24 5125 642936281 XP_008198381.1 2334 7.6e-260 PREDICTED: protein tincar isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B91 453 4.1e-43 Protein tincar OS=Drosophila melanogaster GN=tinc PE=2 SV=1 PF00599 Influenza Matrix protein (M2) GO:0015992 proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036 host cell membrane//virion membrane -- -- Cluster-8309.61561 BP_3 5.00 0.68 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61565 BP_3 35307.77 1626.56 1338 642921056 XP_008192673.1 554 5.0e-54 PREDICTED: hornerin-like [Tribolium castaneum]>gi|270006172|gb|EFA02620.1| hypothetical protein TcasGA2_TC008340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61567 BP_3 4.00 0.54 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6157 BP_3 18.00 0.41 2392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61570 BP_3 4.27 0.76 561 189236834 XP_001812569.1 335 5.2e-29 PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|270005053|gb|EFA01501.1| hypothetical protein TcasGA2_TC007057 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.61578 BP_3 23.24 0.86 1598 642931828 XP_971231.2 1144 2.3e-122 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q0VD31 399 2.3e-37 F-box/LRR-repeat protein 4 OS=Bos taurus GN=FBXL4 PE=2 SV=1 PF00646//PF00560//PF15966//PF13516//PF12937 F-box domain//Leucine Rich Repeat//F-box//Leucine Rich repeat//F-box-like -- -- GO:0005515 protein binding -- -- KOG4341 F-box protein containing LRR Cluster-8309.61579 BP_3 118.86 2.95 2233 642931828 XP_971231.2 1660 4.7e-182 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q8BH70 585 8.7e-59 F-box/LRR-repeat protein 4 OS=Mus musculus GN=Fbxl4 PE=2 SV=1 PF00646//PF00560//PF15966//PF12937 F-box domain//Leucine Rich Repeat//F-box//F-box-like -- -- GO:0005515 protein binding -- -- KOG4341 F-box protein containing LRR Cluster-8309.61585 BP_3 29.69 0.83 2009 215274051 ACJ64923.1 1452 5.6e-158 nicotinic acetylcholine receptor alpha 1 [Leptinotarsa decemlineata] 584600361 KF873578.1 374 0 Locusta migratoria strain Js nicotinic acetylcholine receptor alpha1 variant A mRNA, complete cds, alternatively spliced K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P09478 1374 2.5e-150 Acetylcholine receptor subunit alpha-like 1 OS=Drosophila melanogaster GN=nAChRalpha1 PE=2 SV=2 PF02931//PF05491//PF02932//PF06624 Neurotransmitter-gated ion-channel ligand binding domain//Holliday junction DNA helicase ruvB C-terminus//Neurotransmitter-gated ion-channel transmembrane region//Ribosome associated membrane protein RAMP4 GO:0006811//GO:0006310//GO:0006810//GO:0006281 ion transport//DNA recombination//transport//DNA repair GO:0009378//GO:0005230//GO:0003677 four-way junction helicase activity//extracellular ligand-gated ion channel activity//DNA binding GO:0016020//GO:0005783//GO:0009379//GO:0005657 membrane//endoplasmic reticulum//Holliday junction helicase complex//replication fork KOG3645 Acetylcholine receptor Cluster-8309.61586 BP_3 21.79 1.14 1211 215274051 ACJ64923.1 1091 2.4e-116 nicotinic acetylcholine receptor alpha 1 [Leptinotarsa decemlineata] 704529435 XM_010180496.1 39 1.12626e-08 PREDICTED: Mesitornis unicolor cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4), mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P09478 634 9.8e-65 Acetylcholine receptor subunit alpha-like 1 OS=Drosophila melanogaster GN=nAChRalpha1 PE=2 SV=2 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.61590 BP_3 58.00 2.71 1323 226968626 YP_002808575.1 859 2.1e-89 NADH dehydrogenase subunit 2 [Scylla paramamosain]>gi|225697862|gb|ACO07229.1| NADH dehydrogenase subunit 2 [Scylla paramamosain] 225697849 FJ827761.1 1309 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- P03895 353 4.1e-32 NADH-ubiquinone oxidoreductase chain 2 OS=Drosophila yakuba GN=mt:ND2 PE=3 SV=1 -- -- GO:0055114 oxidation-reduction process -- -- GO:0016020 membrane -- -- Cluster-8309.61591 BP_3 24.00 0.70 1951 501295171 BAN20835.1 1543 1.5e-168 four and a half lim domains [Riptortus pedestris] 689574286 LM044152.1 56 6.50696e-18 Toxocara canis genome assembly T_canis_Equador ,scaffold TCNE_contig0001497 K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 968 3.0e-103 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.61593 BP_3 13.81 0.40 1962 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.616 BP_3 19.00 1.16 1084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61600 BP_3 144.39 2.74 2836 642921802 XP_008199325.1 715 2.3e-72 PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum]>gi|642921804|ref|XP_008199326.1| PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9R007 146 8.9e-08 C-type lectin domain family 5 member A OS=Mus musculus GN=Clec5a PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61602 BP_3 6.00 0.31 1211 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.61607 BP_3 133.92 1.60 4334 546685829 ERL95272.1 1486 1.4e-161 hypothetical protein D910_12538, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TMV3 207 1.2e-14 FAST kinase domain-containing protein 5 OS=Mus musculus GN=Fastkd5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61608 BP_3 30.14 0.36 4383 478251169 ENN71645.1 1292 4.4e-139 hypothetical protein YQE_11743, partial [Dendroctonus ponderosae]>gi|546685828|gb|ERL95271.1| hypothetical protein D910_12537 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6161 BP_3 14.00 0.37 2117 478257458 ENN77614.1 1415 1.1e-153 hypothetical protein YQE_05909, partial [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 797 2.2e-83 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF05493//PF00916//PF06459 ATP synthase subunit H//Sulfate permease family//Ryanodine Receptor TM 4-6 GO:0006816//GO:0008272//GO:0015991//GO:0015992//GO:0006874 calcium ion transport//sulfate transport//ATP hydrolysis coupled proton transport//proton transport//cellular calcium ion homeostasis GO:0015116//GO:0005219//GO:0015078 sulfate transmembrane transporter activity//ryanodine-sensitive calcium-release channel activity//hydrogen ion transmembrane transporter activity GO:0016021//GO:0005622//GO:0033179 integral component of membrane//intracellular//proton-transporting V-type ATPase, V0 domain KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.61610 BP_3 19.17 1.02 1194 478251158 ENN71634.1 860 1.5e-89 hypothetical protein YQE_11732, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843 Herpesvirus tegument protein, N-terminal conserved region GO:0006508 proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-8309.61626 BP_3 57.04 0.39 7413 642921556 XP_008192422.1 3430 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60494 1618 4.8e-178 Cubilin OS=Homo sapiens GN=CUBN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.61627 BP_3 10.79 0.37 1713 478250954 ENN71438.1 495 4.4e-47 hypothetical protein YQE_11857, partial [Dendroctonus ponderosae]>gi|546682677|gb|ERL92589.1| hypothetical protein D910_09902 [Dendroctonus ponderosae] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 Q9GZS0 370 5.7e-34 Dynein intermediate chain 2, axonemal OS=Homo sapiens GN=DNAI2 PE=1 SV=2 PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.61630 BP_3 12.00 0.41 1696 -- -- -- -- -- 768311753 CP010981.1 1664 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- Q4WG16 791 8.6e-83 Probable glucan endo-1,3-beta-glucosidase eglC OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=eglC PE=3 SV=1 PF00332 Glycosyl hydrolases family 17 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.61631 BP_3 68.00 2.89 1427 717007159 AIW68607.1 1627 2.0e-178 glyceraldehyde-3-phosphate-dehydrogenase [Cherax quadricarinatus] 402485601 JX257000.1 1410 0 Scylla paramamosain glyceraldehyde-3-phosphate dehydrogenase mRNA, complete cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 P56649 1609 1.0e-177 Glyceraldehyde-3-phosphate dehydrogenase OS=Panulirus versicolor PE=1 SV=1 PF00044//PF02826//PF02800 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0051287//GO:0016620 NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.61632 BP_3 29.00 0.65 2432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61634 BP_3 37.01 0.89 2294 546678425 ERL89048.1 254 5.3e-19 hypothetical protein D910_06426 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGY6 182 4.8e-12 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61637 BP_3 8.01 0.76 801 478254862 ENN75098.1 272 1.5e-21 hypothetical protein YQE_08411, partial [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 168 7.1e-11 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.61638 BP_3 1.00 1.08 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61640 BP_3 511.44 8.94 3050 642921056 XP_008192673.1 465 2.4e-43 PREDICTED: hornerin-like [Tribolium castaneum]>gi|270006172|gb|EFA02620.1| hypothetical protein TcasGA2_TC008340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15150 Phorbol-12-myristate-13-acetate-induced GO:0006919//GO:0001836//GO:0006974//GO:0006915 activation of cysteine-type endopeptidase activity involved in apoptotic process//release of cytochrome c from mitochondria//cellular response to DNA damage stimulus//apoptotic process -- -- -- -- -- -- Cluster-8309.61641 BP_3 116.00 1.55 3906 642921058 XP_008192674.1 773 5.9e-79 PREDICTED: uncharacterized protein LOC103312822 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05732//PF00335 Firmicute plasmid replication protein (RepL)//Tetraspanin family GO:0006276//GO:0006260 plasmid maintenance//DNA replication -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.61643 BP_3 1.26 0.37 456 478249775 ENN70283.1 265 5.5e-21 hypothetical protein YQE_13066, partial [Dendroctonus ponderosae] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 161 2.6e-10 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.61647 BP_3 19.73 1.04 1207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02687 FtsX-like permease family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.61654 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02257 RFX DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.61658 BP_3 1.00 1.25 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61666 BP_3 278.00 3.82 3802 478258638 ENN78688.1 572 1.2e-55 hypothetical protein YQE_04860, partial [Dendroctonus ponderosae] -- -- -- -- -- K09414 HSF1 heat shock transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09414 P38532 443 4.3e-42 Heat shock factor protein 1 OS=Mus musculus GN=Hsf1 PE=1 SV=2 PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0627 Heat shock transcription factor Cluster-8309.61672 BP_3 14.87 5.55 420 642922790 XP_008193326.1 225 2.2e-16 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P56652 149 5.9e-09 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Bos taurus GN=ITIH3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61675 BP_3 9.00 0.63 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61679 BP_3 33.79 0.59 3058 642937652 XP_966876.3 613 1.6e-60 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95LI3 440 7.8e-42 Zinc finger Y-chromosomal protein OS=Bos taurus GN=ZFY PE=2 SV=1 PF00096//PF13465//PF07776//PF05485//PF01363//PF07649 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//THAP domain//FYVE zinc finger//C1-like domain GO:0055114 oxidation-reduction process GO:0047134//GO:0046872//GO:0008270//GO:0003676 protein-disulfide reductase activity//metal ion binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.61683 BP_3 5.00 0.31 1070 861615279 KMQ86061.1 304 3.9e-25 retrovirus-related pol polyprotein from transposon tnt 1-94 [Lasius niger] -- -- -- -- -- -- -- -- -- P10978 126 7.0e-06 Retrovirus-related Pol polyprotein from transposon TNT 1-94 OS=Nicotiana tabacum PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61684 BP_3 5.00 0.54 741 645022944 XP_008218060.1 549 1.0e-53 PREDICTED: uncharacterized protein LOC100680482 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02545 Maf-like protein -- -- -- -- GO:0005737 cytoplasm -- -- Cluster-8309.61687 BP_3 699.48 54.27 913 642920497 XP_008192376.1 649 3.3e-65 PREDICTED: head-specific guanylate cyclase [Tribolium castaneum]>gi|270005900|gb|EFA02348.1| hypothetical protein TcasGA2_TC008018 [Tribolium castaneum] -- -- -- -- -- K12318 GUCY1A guanylate cyclase soluble subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K12318 P19686 481 4.1e-47 Guanylate cyclase soluble subunit alpha-3 OS=Rattus norvegicus GN=Gucy1a3 PE=1 SV=1 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0006144 cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//purine nucleobase metabolic process GO:0000166//GO:0004383//GO:0020037//GO:0016849 nucleotide binding//guanylate cyclase activity//heme binding//phosphorus-oxygen lyase activity GO:0005622 intracellular KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.6169 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61690 BP_3 1.00 0.44 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61695 BP_3 4.00 0.37 816 642928433 XP_008193783.1 262 2.2e-20 PREDICTED: proteasome activator complex subunit 4 [Tribolium castaneum]>gi|270010813|gb|EFA07261.1| hypothetical protein TcasGA2_TC013292 [Tribolium castaneum] -- -- -- -- -- K06699 PSME4 proteasome activator subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06699 F1MKX4 138 2.2e-07 Proteasome activator complex subunit 4 OS=Bos taurus GN=PSME4 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61696 BP_3 6.00 0.35 1110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61703 BP_3 16.00 0.60 1571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61704 BP_3 11.23 0.61 1179 642917366 XP_008199274.1 1083 2.0e-115 PREDICTED: transmembrane channel-like protein 3 [Tribolium castaneum] 242003851 XM_002422840.1 86 8.17524e-35 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- Q8R4P4 543 3.4e-54 Transmembrane channel-like protein 2 OS=Mus musculus GN=Tmc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61715 BP_3 6.46 0.61 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.61716 BP_3 2.00 0.75 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.61720 BP_3 13.93 0.37 2112 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61721 BP_3 36.00 2.27 1056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61734 BP_3 1.00 0.38 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61736 BP_3 3.00 0.39 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61738 BP_3 53.00 13.92 475 238683667 ACR54112.1 278 1.8e-22 ribosomal protein P1 [Palaemon varians] 262401192 FJ774778.1 214 2.2129e-106 Scylla paramamosain putative 60S acidic ribosomal protein P1 mRNA, partial cds K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P02402 239 2.5e-19 60S acidic ribosomal protein P1 OS=Artemia salina PE=1 SV=2 PF01213//PF01698 Adenylate cyclase associated (CAP) N terminal//Floricaula / Leafy protein GO:0006355//GO:0007010 regulation of transcription, DNA-templated//cytoskeleton organization GO:0003677//GO:0003779 DNA binding//actin binding -- -- KOG1762 60s acidic ribosomal protein P1 Cluster-8309.61740 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61743 BP_3 7.00 0.80 711 270016078 EFA12526.1 407 3.0e-37 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 268 1.6e-22 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61744 BP_3 2.00 0.34 578 546685837 ERL95276.1 321 2.2e-27 hypothetical protein D910_12542 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P20825 154 2.1e-09 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.61745 BP_3 14.61 0.32 2487 546681015 ERL91180.1 1694 6.0e-186 hypothetical protein D910_08519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q04519 680 9.4e-70 Sphingomyelin phosphodiesterase OS=Mus musculus GN=Smpd1 PE=2 SV=2 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.61755 BP_3 21.00 0.59 2008 91091268 XP_969284.1 476 8.3e-45 PREDICTED: uncharacterized protein LOC657749 [Tribolium castaneum]>gi|270014119|gb|EFA10567.1| hypothetical protein TcasGA2_TC012823 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00901//PF02505 Orbivirus outer capsid protein VP5//Methyl-coenzyme M reductase operon protein D GO:0015948 methanogenesis GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.6176 BP_3 23.00 0.52 2411 270015467 EFA11915.1 604 1.4e-59 hypothetical protein TcasGA2_TC004072 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10613//PF00060//PF15745 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//AP-1 complex-associated regulatory protein GO:1900025//GO:0048203//GO:0034315//GO:0006811//GO:0007165//GO:2000146//GO:0007268 negative regulation of substrate adhesion-dependent cell spreading//vesicle targeting, trans-Golgi to endosome//regulation of Arp2/3 complex-mediated actin nucleation//ion transport//signal transduction//negative regulation of cell motility//synaptic transmission GO:0035650//GO:0005234//GO:0004970 AP-1 adaptor complex binding//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.61761 BP_3 5.86 0.56 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61765 BP_3 1.00 0.34 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61779 BP_3 2.00 0.44 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6178 BP_3 19.63 0.43 2479 471190887 XP_004185151.1 312 1.1e-25 hypothetical protein EIN_281760 [Entamoeba invadens IP1]>gi|440292618|gb|ELP85805.1| hypothetical protein EIN_281760 [Entamoeba invadens IP1] -- -- -- -- -- -- -- -- -- Q54G05 274 1.1e-22 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF11365//PF00397 Protein of unknown function (DUF3166)//WW domain GO:0010506 regulation of autophagy GO:0005515 protein binding GO:0005615 extracellular space -- -- Cluster-8309.61781 BP_3 6.00 0.40 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61782 BP_3 4.00 0.36 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03606 C4-dicarboxylate anaerobic carrier -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.61786 BP_3 99.64 1.69 3132 642932892 XP_008197175.1 620 2.6e-61 PREDICTED: uncharacterized protein LOC103314074 [Tribolium castaneum]>gi|270011476|gb|EFA07924.1| hypothetical protein TcasGA2_TC005502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61790 BP_3 31.10 1.27 1476 546678978 ERL89511.1 413 1.2e-37 hypothetical protein D910_06877 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61791 BP_3 232.00 3.45 3534 612063330 XP_007506682.1 192 1.3e-11 PREDICTED: zinc finger protein 845-like [Monodelphis domestica] 642917153 XM_008192918.1 338 2.04989e-174 PREDICTED: Tribolium castaneum zinc finger protein 396 (LOC659973), transcript variant X2, mRNA -- -- -- -- O14709 185 3.3e-12 Zinc finger protein 197 OS=Homo sapiens GN=ZNF197 PE=2 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.61795 BP_3 7.00 0.92 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61796 BP_3 25.00 2.06 877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61797 BP_3 33.00 1.78 1184 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61800 BP_3 9.50 0.39 1469 270008057 EFA04505.1 996 3.1e-105 hypothetical protein TcasGA2_TC014813 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y624 141 1.8e-07 Junctional adhesion molecule A OS=Homo sapiens GN=F11R PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61801 BP_3 34.15 1.51 1384 270008057 EFA04505.1 996 2.9e-105 hypothetical protein TcasGA2_TC014813 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y624 141 1.6e-07 Junctional adhesion molecule A OS=Homo sapiens GN=F11R PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61804 BP_3 38.00 1.52 1499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01466 Skp1 family, dimerisation domain GO:0006511 ubiquitin-dependent protein catabolic process -- -- -- -- -- -- Cluster-8309.61806 BP_3 8.24 1.08 658 270008674 EFA05122.1 308 8.2e-26 hypothetical protein TcasGA2_TC015236 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 189 2.1e-13 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.61808 BP_3 3.00 0.34 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61811 BP_3 18.00 1.74 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61819 BP_3 10.00 0.31 1841 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61820 BP_3 6.00 0.73 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61822 BP_3 31.22 0.35 4608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00081//PF11411 Iron/manganese superoxide dismutases, alpha-hairpin domain//DNA ligase IV GO:0055114//GO:0006281//GO:0006801//GO:0006260 oxidation-reduction process//DNA repair//superoxide metabolic process//DNA replication GO:0003910//GO:0004784//GO:0046872 DNA ligase (ATP) activity//superoxide dismutase activity//metal ion binding -- -- -- -- Cluster-8309.61824 BP_3 42.34 0.98 2370 642934168 XP_008199635.1 1279 7.6e-138 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.71653e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 Q5ZKY2 815 2.0e-85 Ubiquitin-like modifier-activating enzyme ATG7 OS=Gallus gallus GN=ATG7 PE=2 SV=1 PF13241//PF02558//PF02826//PF00899 Putative NAD(P)-binding//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//ThiF family GO:0055114//GO:0006779//GO:0019354//GO:0015940 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//pantothenate biosynthetic process GO:0008677//GO:0008641//GO:0043115//GO:0051287 2-dehydropantoate 2-reductase activity//small protein activating enzyme activity//precorrin-2 dehydrogenase activity//NAD binding -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.61831 BP_3 52.99 1.48 2016 642921794 XP_970012.2 1840 5.7e-203 PREDICTED: protein FAM73B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLE2 717 3.9e-74 Protein FAM73B OS=Danio rerio GN=fam73b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3831 Uncharacterized conserved protein Cluster-8309.61841 BP_3 4.00 0.43 740 607356477 EZA50993.1 326 7.6e-28 hypothetical protein X777_10520 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.61842 BP_3 2.00 0.83 406 270003239 EEZ99686.1 189 3.2e-12 hypothetical protein TcasGA2_TC002443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61844 BP_3 3.00 0.37 680 328717769 XP_001947664.2 209 2.6e-14 PREDICTED: uncharacterized protein LOC100160378, partial [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61845 BP_3 25.08 0.43 3073 328717769 XP_001947664.2 1385 5.0e-150 PREDICTED: uncharacterized protein LOC100160378, partial [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P04323 653 1.6e-66 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.61846 BP_3 4.00 0.68 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61852 BP_3 156.67 11.79 932 642917092 XP_008191113.1 794 5.2e-82 PREDICTED: U6 snRNA phosphodiesterase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DEF6 489 4.9e-48 U6 snRNA phosphodiesterase OS=Danio rerio GN=usb1 PE=2 SV=1 PF09749 Uncharacterised conserved protein GO:0034477 U6 snRNA 3'-end processing GO:0004518 nuclease activity -- -- KOG3102 Uncharacterized conserved protein Cluster-8309.61859 BP_3 48.77 0.75 3412 332374784 AEE62533.1 1039 7.4e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8SWR3 136 1.5e-06 Sex peptide receptor OS=Drosophila melanogaster GN=SPR PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.61862 BP_3 14.71 0.52 1662 332374784 AEE62533.1 867 3.2e-90 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8SWR3 136 7.5e-07 Sex peptide receptor OS=Drosophila melanogaster GN=SPR PE=1 SV=1 PF01226//PF00001 Formate/nitrite transporter//7 transmembrane receptor (rhodopsin family) GO:0006810//GO:0007186 transport//G-protein coupled receptor signaling pathway GO:0005215//GO:0004930 transporter activity//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.61863 BP_3 3.66 0.57 600 642929994 XP_008196057.1 217 2.7e-15 PREDICTED: uncharacterized protein LOC664557 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61865 BP_3 11.00 0.75 999 751813228 AJG01361.1 878 1.0e-91 sarcoplasmic calcium-binding protein variant c [Eriocheir sinensis] 387571562 JQ860424.1 830 0 Scylla paramamosain sarcoplasmic calcium-binding protein (SCP) mRNA, complete cds -- -- -- -- P05946 839 1.4e-88 Sarcoplasmic calcium-binding protein 1 OS=Astacus leptodactylus PE=1 SV=1 PF12763//PF13202//PF13499//PF13833//PF13405//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.61866 BP_3 13.00 0.36 2029 260806959 XP_002598351.1 337 1.1e-28 hypothetical protein BRAFLDRAFT_204721 [Branchiostoma floridae]>gi|229283623|gb|EEN54363.1| hypothetical protein BRAFLDRAFT_204721, partial [Branchiostoma floridae] 597789830 XM_007258237.1 65 6.72412e-23 PREDICTED: Astyanax mexicanus hepatic leukemia factor-like (LOC103025119), mRNA K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q8BW74 316 1.2e-27 Hepatic leukemia factor OS=Mus musculus GN=Hlf PE=2 SV=1 PF00170//PF07716//PF01213//PF03131 bZIP transcription factor//Basic region leucine zipper//Adenylate cyclase associated (CAP) N terminal//bZIP Maf transcription factor GO:0006355//GO:0007010 regulation of transcription, DNA-templated//cytoskeleton organization GO:0043565//GO:0003700//GO:0003677//GO:0003779 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//actin binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.61869 BP_3 553.98 10.19 2913 642931247 XP_008196499.1 1120 2.5e-119 PREDICTED: protein yellow [Tribolium castaneum]>gi|270012127|gb|EFA08575.1| hypothetical protein TcasGA2_TC006230 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI23 507 1.3e-49 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61871 BP_3 77.36 0.95 4224 688556539 XP_009300010.1 1306 1.0e-140 PREDICTED: general transcription factor II-I repeat domain-containing protein 2-like [Danio rerio] -- -- -- -- -- -- -- -- -- A4IFA3 913 1.5e-96 General transcription factor II-I repeat domain-containing protein 2 OS=Bos taurus GN=GTF2IRD2 PE=2 SV=1 PF05699//PF00253 hAT family C-terminal dimerisation region//Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0046983 structural constituent of ribosome//protein dimerization activity GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.61881 BP_3 29.65 1.07 1630 642926106 XP_008194787.1 1739 2.4e-191 PREDICTED: rabphilin-3A [Tribolium castaneum] 462477511 APGK01000290.1 49 4.21718e-14 Dendroctonus ponderosae Seq01000290, whole genome shotgun sequence -- -- -- -- Q06846 589 2.2e-59 Rabphilin-3A OS=Bos taurus GN=RPH3A PE=1 SV=1 PF05715//PF00168//PF01363 Piccolo Zn-finger//C2 domain//FYVE zinc finger -- -- GO:0005515//GO:0046872 protein binding//metal ion binding GO:0045202 synapse KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.61886 BP_3 92.20 3.11 1720 189239358 XP_974445.2 1222 2.2e-131 PREDICTED: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [Tribolium castaneum] 817088660 XM_012411735.1 54 7.40246e-17 PREDICTED: Athalia rosae tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (LOC105692505), transcript variant X2, mRNA K05545 DUS4 tRNA-dihydrouridine synthase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05545 Q32M08 710 2.2e-73 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like OS=Mus musculus GN=Dus4l PE=2 SV=1 PF00977//PF01207 Histidine biosynthesis protein//Dihydrouridine synthase (Dus) GO:0000105//GO:0055114//GO:0008033 histidine biosynthetic process//oxidation-reduction process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.61887 BP_3 13.15 0.79 1092 478259929 ENN79731.1 853 8.7e-89 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 464 4.6e-45 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006412//GO:0015992//GO:0006123 translation//proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.61897 BP_3 22.95 0.66 1958 642937544 XP_008199089.1 705 2.3e-71 PREDICTED: major facilitator superfamily domain-containing protein 9-like isoform X2 [Tribolium castaneum]>gi|270001229|gb|EEZ97676.1| hypothetical protein TcasGA2_TC016221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0T7 290 1.2e-24 Major facilitator superfamily domain-containing protein 9 OS=Mus musculus GN=Mfsd9 PE=2 SV=1 PF07690//PF05121//PF00083 Major Facilitator Superfamily//Gas vesicle protein K//Sugar (and other) transporter GO:0031412//GO:0055085 gas vesicle organization//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.61900 BP_3 19.18 2.38 680 478249761 ENN70269.1 542 6.2e-53 hypothetical protein YQE_13052, partial [Dendroctonus ponderosae]>gi|546677441|gb|ERL88278.1| hypothetical protein D910_05665 [Dendroctonus ponderosae] -- -- -- -- -- K13254 SPAST spastin http://www.genome.jp/dbget-bin/www_bget?ko:K13254 Q7QBW0 435 6.6e-42 Spastin OS=Anopheles gambiae GN=spas PE=3 SV=6 PF13414//PF00515//PF13181//PF14863 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Alkyl sulfatase dimerisation -- -- GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.61901 BP_3 10.00 0.81 888 780168081 XP_011684075.1 280 2.0e-22 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q8N8A2 237 7.8e-19 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens GN=ANKRD44 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61907 BP_3 69.13 5.20 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04614 Pex19 protein family -- -- -- -- GO:0005777 peroxisome -- -- Cluster-8309.61908 BP_3 2.00 1.16 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61909 BP_3 2.54 0.32 673 91078706 XP_971901.1 712 1.2e-72 PREDICTED: putative RNA exonuclease NEF-sp [Tribolium castaneum]>gi|270003754|gb|EFA00202.1| hypothetical protein TcasGA2_TC003027 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q4R9F7 301 2.2e-26 Putative RNA exonuclease NEF-sp OS=Macaca fascicularis GN=QtsA-10054 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2248 3'-5' exonuclease Cluster-8309.6191 BP_3 13.00 0.68 1220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61912 BP_3 42.68 2.37 1160 270002473 EEZ98920.1 700 5.1e-71 hypothetical protein TcasGA2_TC004539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 221 7.3e-17 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.61915 BP_3 3.00 0.47 601 641657806 XP_008180482.1 295 2.4e-24 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61916 BP_3 27.65 0.32 4403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02898//PF00290//PF04625 Nitric oxide synthase, oxygenase domain//Tryptophan synthase alpha chain//DEC-1 protein, N-terminal region GO:0006809//GO:0000162//GO:0006571//GO:0055114//GO:0007304//GO:0006568//GO:0009094 nitric oxide biosynthetic process//tryptophan biosynthetic process//tyrosine biosynthetic process//oxidation-reduction process//chorion-containing eggshell formation//tryptophan metabolic process//L-phenylalanine biosynthetic process GO:0004834//GO:0004517//GO:0005213 tryptophan synthase activity//nitric-oxide synthase activity//structural constituent of chorion GO:0042600//GO:0005576 chorion//extracellular region -- -- Cluster-8309.61919 BP_3 82.82 1.96 2332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61920 BP_3 26.09 2.42 812 189238253 XP_001813297.1 960 2.5e-101 PREDICTED: GPN-loop GTPase 3 [Tribolium castaneum]>gi|270008652|gb|EFA05100.1| hypothetical protein TcasGA2_TC015199 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9D3W4 705 3.9e-73 GPN-loop GTPase 3 OS=Mus musculus GN=Gpn3 PE=2 SV=1 PF01926//PF00005//PF00910//PF00437//PF00004 50S ribosome-binding GTPase//ABC transporter//RNA helicase//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0006810 transport GO:0003724//GO:0016887//GO:0003723//GO:0005525//GO:0005524//GO:0000166 RNA helicase activity//ATPase activity//RNA binding//GTP binding//ATP binding//nucleotide binding -- -- KOG1534 Putative transcription factor FET5 Cluster-8309.61928 BP_3 10.07 1.17 705 752876315 XP_011255548.1 259 4.2e-20 PREDICTED: uncharacterized protein LOC105250894 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6193 BP_3 3.00 0.43 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61932 BP_3 15.70 0.53 1718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61934 BP_3 29.00 1.07 1601 270005566 EFA02014.1 507 1.7e-48 hypothetical protein TcasGA2_TC007637 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09026 Centromere protein B dimerisation domain GO:0006355 regulation of transcription, DNA-templated GO:0003682//GO:0003677 chromatin binding//DNA binding GO:0000775//GO:0000785//GO:0005634 chromosome, centromeric region//chromatin//nucleus -- -- Cluster-8309.61935 BP_3 29.00 1.16 1497 642919228 XP_008191786.1 1583 2.7e-173 PREDICTED: dachshund homolog 1 [Tribolium castaneum] 642919227 XM_008193564.1 365 0 PREDICTED: Tribolium castaneum dachshund homolog 1 (LOC652934), mRNA -- -- -- -- Q9UI36 497 9.4e-49 Dachshund homolog 1 OS=Homo sapiens GN=DACH1 PE=1 SV=3 PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG3915 Transcription regulator dachshund, contains SKI/SNO domain Cluster-8309.61942 BP_3 76.35 0.61 6277 91090584 XP_972498.1 2324 1.3e-258 PREDICTED: histone H2A deubiquitinase MYSM1 isoform X1 [Tribolium castaneum]>gi|270013339|gb|EFA09787.1| hypothetical protein TcasGA2_TC011929 [Tribolium castaneum] -- -- -- -- -- K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 P55216 782 3.5e-81 Putative cystathionine gamma-lyase 2 OS=Caenorhabditis elegans GN=cth-2 PE=3 SV=1 PF00155//PF01053//PF02347//PF04433//PF01398 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme//Glycine cleavage system P-protein//SWIRM domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0009058//GO:0006546//GO:0006544//GO:0055114//GO:0006566//GO:0006563 biosynthetic process//glycine catabolic process//glycine metabolic process//oxidation-reduction process//threonine metabolic process//L-serine metabolic process GO:0004375//GO:0005515//GO:0030170 glycine dehydrogenase (decarboxylating) activity//protein binding//pyridoxal phosphate binding -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.61943 BP_3 48.37 2.06 1423 270012018 EFA08466.1 819 9.9e-85 hypothetical protein TcasGA2_TC006115 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 506 8.1e-50 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61958 BP_3 14.39 0.39 2058 642933166 XP_008197284.1 1789 4.8e-197 PREDICTED: hexosaminidase D-like [Tribolium castaneum]>gi|270012547|gb|EFA08995.1| hypothetical protein TcasGA2_TC006702 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 712 1.5e-73 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- -- -- Cluster-8309.61959 BP_3 182.64 4.34 2321 642933166 XP_008197284.1 2057 4.5e-228 PREDICTED: hexosaminidase D-like [Tribolium castaneum]>gi|270012547|gb|EFA08995.1| hypothetical protein TcasGA2_TC006702 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 769 4.2e-80 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0043169//GO:0004553 cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.61960 BP_3 95.55 1.42 3525 642925895 XP_008190722.1 1469 1.0e-159 PREDICTED: uncharacterized protein LOC661054 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 801 1.2e-83 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.61961 BP_3 2.00 5.45 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61963 BP_3 3.00 0.31 758 642914286 XP_008201622.1 278 2.9e-22 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 A2BHJ4 162 3.3e-10 CCR4-NOT transcription complex subunit 6-like OS=Danio rerio GN=cnot6l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.61965 BP_3 7.00 0.54 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12861 Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex -- -- Cluster-8309.61967 BP_3 1.00 4.87 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6197 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61972 BP_3 19.00 0.65 1706 270003086 EEZ99533.1 494 5.8e-47 hypothetical protein TcasGA2_TC000115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2BF66 155 4.8e-09 HORMA domain-containing protein 1 OS=Danio rerio GN=hormad1 PE=2 SV=1 PF00130//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.61973 BP_3 1.00 1.89 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61974 BP_3 3.00 0.32 742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61999 BP_3 2.01 0.46 501 514683686 XP_004989424.1 172 3.7e-10 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 -- -- -- -- PF02150//PF04988//PF00096//PF13465 RNA polymerases M/15 Kd subunit//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.62 BP_3 13.00 3.76 458 22758848 AAN05584.1 515 5.7e-50 ribosomal protein L30 [Argopecten irradians] 172051117 EU574827.1 107 6.44021e-47 Ornithodoros coriaceus clone OC-30 ribosomal protein L30 mRNA, partial cds K02908 RP-L30e, RPL30 large subunit ribosomal protein L30e http://www.genome.jp/dbget-bin/www_bget?ko:K02908 P67884 481 2.0e-47 60S ribosomal protein L30 OS=Ophiophagus hannah GN=RPL30 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2988 60S ribosomal protein L30 Cluster-8309.6200 BP_3 46.31 0.89 2797 820863630 XP_012348468.1 163 2.3e-08 PREDICTED: putative uncharacterized protein DDB_G0286901 isoform X2 [Apis florea] -- -- -- -- -- -- -- -- -- P87498 134 2.2e-06 Vitellogenin-1 OS=Gallus gallus GN=VTG1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62006 BP_3 27.79 0.58 2616 4559259 AAD22957.1 3452 0.0e+00 voltage-sensitive sodium channel [Leptinotarsa decemlineata] 756767049 KJ699123.1 856 0 Brassicogethes aeneus isolate Wlkp_PL voltage-sensitive sodium channel mRNA, complete cds K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 P35500 2538 3.5e-285 Sodium channel protein para OS=Drosophila melanogaster GN=para PE=2 SV=3 PF00520//PF06016//PF06512 Ion transport protein//Reovirus core-spike protein lambda-2 (L2)//Sodium ion transport-associated GO:0055085//GO:0006811//GO:0006814//GO:0006370//GO:0009451 transmembrane transport//ion transport//sodium ion transport//7-methylguanosine mRNA capping//RNA modification GO:0004484//GO:0005524//GO:0005248//GO:0004482//GO:0005216 mRNA guanylyltransferase activity//ATP binding//voltage-gated sodium channel activity//mRNA (guanine-N7-)-methyltransferase activity//ion channel activity GO:0019028//GO:0001518//GO:0016020 viral capsid//voltage-gated sodium channel complex//membrane -- -- Cluster-8309.6201 BP_3 7.12 0.33 1326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62011 BP_3 41.00 0.89 2524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04689 DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.62019 BP_3 19.00 0.90 1306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62024 BP_3 1.00 3.12 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62026 BP_3 1.00 0.38 418 332374180 AEE62231.1 505 7.5e-49 unknown [Dendroctonus ponderosae]>gi|546686938|gb|ERL95916.1| hypothetical protein D910_00598 [Dendroctonus ponderosae]>gi|546686945|gb|ERL95921.1| hypothetical protein D910_00602 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DAK2 392 3.9e-37 Parkin coregulated gene protein homolog OS=Mus musculus GN=Pacrg PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3961 Uncharacterized conserved protein Cluster-8309.62030 BP_3 4.85 0.71 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62031 BP_3 11.00 0.74 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62032 BP_3 18.00 0.33 2913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62033 BP_3 23.94 0.57 2299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62036 BP_3 11.23 0.56 1254 414448076 AFW99840.1 521 3.1e-50 troponin I [Litopenaeus vannamei] 414448055 JX683730.1 312 2.02941e-160 Litopenaeus vannamei clone TPNi3 troponin I mRNA, complete cds -- -- -- -- P05547 519 2.2e-51 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992 Troponin -- -- -- -- GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.62037 BP_3 28.00 0.58 2602 270007809 EFA04257.1 504 6.1e-48 hypothetical protein TcasGA2_TC014547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54J55 231 1.1e-17 Myb-like protein X OS=Dictyostelium discoideum GN=mybX PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62040 BP_3 27.36 0.73 2094 642918792 XP_008191586.1 583 3.4e-57 PREDICTED: derriere protein-like [Tribolium castaneum] -- -- -- -- -- K04664 GDF5_6_7 growth differentiation factor 5/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04664 Q9YGV1 232 7.0e-18 Derriere protein OS=Xenopus laevis GN=derriere PE=1 SV=1 PF00019//PF12763//PF00688 Transforming growth factor beta like domain//Cytoskeletal-regulatory complex EF hand//TGF-beta propeptide GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083//GO:0005515 growth factor activity//protein binding -- -- -- -- Cluster-8309.62041 BP_3 32.79 0.89 2064 642918792 XP_008191586.1 583 3.3e-57 PREDICTED: derriere protein-like [Tribolium castaneum] -- -- -- -- -- K04664 GDF5_6_7 growth differentiation factor 5/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04664 Q9YGV1 232 6.9e-18 Derriere protein OS=Xenopus laevis GN=derriere PE=1 SV=1 PF12763//PF00688//PF00019 Cytoskeletal-regulatory complex EF hand//TGF-beta propeptide//Transforming growth factor beta like domain GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0005515//GO:0008083 protein binding//growth factor activity -- -- -- -- Cluster-8309.62044 BP_3 8.00 0.34 1432 768422365 XP_011552034.1 459 5.5e-43 PREDICTED: coiled-coil domain-containing protein 96-like isoform X2 [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q9CR92 210 1.7e-15 Coiled-coil domain-containing protein 96 OS=Mus musculus GN=Ccdc96 PE=2 SV=1 PF02601//PF05478//PF10473 Exonuclease VII, large subunit//Prominin//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006308 DNA catabolic process GO:0008855//GO:0045502//GO:0008134//GO:0042803 exodeoxyribonuclease VII activity//dynein binding//transcription factor binding//protein homodimerization activity GO:0016021//GO:0030286//GO:0005667//GO:0009318 integral component of membrane//dynein complex//transcription factor complex//exodeoxyribonuclease VII complex -- -- Cluster-8309.62045 BP_3 29.80 0.95 1808 675378821 KFM71723.1 515 2.2e-49 Zinc finger protein 271, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 483 4.8e-47 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF13912//PF17123//PF01475//PF15750//PF13465//PF00096 C2H2-type zinc finger//RING-like zinc finger//Ferric uptake regulator family//Ubiquitin-binding zinc-finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0043130//GO:0008270//GO:0046872//GO:0005515//GO:0003700 ubiquitin binding//zinc ion binding//metal ion binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.62055 BP_3 12.00 0.75 1068 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62057 BP_3 41478.00 1679.63 1482 642922070 XP_008193006.1 354 8.6e-31 PREDICTED: cuticle protein 19-like [Tribolium castaneum]>gi|270008195|gb|EFA04643.1| cuticular protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 282 7.9e-24 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.62058 BP_3 2.00 1.16 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62061 BP_3 6.43 0.59 818 546679671 ERL90098.1 266 7.6e-21 hypothetical protein D910_07452 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702//PF04889//PF06156//PF04977 Fibrinogen alpha/beta chain family//Cwf15/Cwc15 cell cycle control protein//Protein of unknown function (DUF972)//Septum formation initiator GO:0030168//GO:0006260//GO:0007049//GO:0000398//GO:0007165//GO:0051258 platelet activation//DNA replication//cell cycle//mRNA splicing, via spliceosome//signal transduction//protein polymerization GO:0030674//GO:0005102 protein binding, bridging//receptor binding GO:0005577//GO:0005681 fibrinogen complex//spliceosomal complex -- -- Cluster-8309.62067 BP_3 68.82 2.21 1795 542258197 XP_005464423.1 728 4.5e-74 PREDICTED: zinc finger protein 569-like isoform X1 [Oreochromis niloticus]>gi|542258199|ref|XP_005464424.1| PREDICTED: zinc finger protein 569-like isoform X2 [Oreochromis niloticus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q61116 711 1.7e-73 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF00096//PF13465//PF13912//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.62069 BP_3 14.00 0.55 1525 675369431 KFM62333.1 174 6.6e-10 CCAAT/enhancer-binding protein gamma, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P53568 130 3.4e-06 CCAAT/enhancer-binding protein gamma OS=Mus musculus GN=Cebpg PE=1 SV=1 PF07851//PF04977//PF04111//PF00424//PF00170//PF07716//PF06005 TMPIT-like protein//Septum formation initiator//Autophagy protein Apg6//REV protein (anti-repression trans-activator protein)//bZIP transcription factor//Basic region leucine zipper//Protein of unknown function (DUF904) GO:0006355//GO:0043093//GO:0000917//GO:0007049//GO:0006914 regulation of transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle//autophagy GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005737//GO:0042025//GO:0016021//GO:0005667 cytoplasm//host cell nucleus//integral component of membrane//transcription factor complex -- -- Cluster-8309.62071 BP_3 26.00 0.43 3204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04542//PF00440 Sigma-70 region 2//Bacterial regulatory proteins, tetR family GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0003700 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.62082 BP_3 58.44 1.44 2247 270010034 EFA06482.1 197 2.1e-12 hypothetical protein TcasGA2_TC009377 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62083 BP_3 18.35 0.49 2082 642934069 XP_008195970.1 2790 0.0e+00 PREDICTED: potassium voltage-gated channel subfamily H member 8 isoform X4 [Tribolium castaneum] 195150786 XM_002016296.1 171 8.20262e-82 Drosophila persimilis GL11522 (Dper\GL11522), mRNA K04911 KCNH8 potassium voltage-gated channel Eag-related subfamily H member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K04911 P59111 1692 3.5e-187 Potassium voltage-gated channel subfamily H member 8 OS=Mus musculus GN=Kcnh8 PE=2 SV=2 PF01007//PF00520//PF00064 Inward rectifier potassium channel//Ion transport protein//Neuraminidase GO:0005975//GO:0006811//GO:0006687//GO:0006813//GO:0055085 carbohydrate metabolic process//ion transport//glycosphingolipid metabolic process//potassium ion transport//transmembrane transport GO:0005216//GO:0005242//GO:0004308 ion channel activity//inward rectifier potassium channel activity//exo-alpha-sialidase activity GO:0008076//GO:0033644//GO:0016020//GO:0055036//GO:0016021 voltage-gated potassium channel complex//host cell membrane//membrane//virion membrane//integral component of membrane -- -- Cluster-8309.62086 BP_3 55.00 4.15 930 242012247 XP_002426845.1 255 1.6e-19 Perlucin, putative [Pediculus humanus corporis]>gi|212511058|gb|EEB14107.1| Perlucin, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- P82596 143 6.5e-08 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62087 BP_3 16.61 0.45 2062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62089 BP_3 19.31 0.57 1911 607361066 EZA55368.1 392 4.4e-35 hypothetical protein X777_04821 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62090 BP_3 13.00 0.50 1535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62092 BP_3 313.59 9.52 1879 642921031 XP_008192662.1 635 2.8e-63 PREDICTED: harmonin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62093 BP_3 33.82 0.39 4467 332372560 AEE61422.1 791 5.5e-81 unknown [Dendroctonus ponderosae]>gi|478257372|gb|ENN77530.1| hypothetical protein YQE_05978, partial [Dendroctonus ponderosae]>gi|546685343|gb|ERL94870.1| hypothetical protein D910_12143 [Dendroctonus ponderosae] -- -- -- -- -- K10687 UBE2F ubiquitin-conjugating enzyme E2 F http://www.genome.jp/dbget-bin/www_bget?ko:K10687 Q5M8Y2 566 2.8e-56 NEDD8-conjugating enzyme UBE2F OS=Xenopus tropicalis GN=ube2f PE=2 SV=1 PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0005737//GO:0016020 cytoplasm//membrane KOG0420 Ubiquitin-protein ligase Cluster-8309.62094 BP_3 18.15 0.72 1504 642921434 XP_008192864.1 334 1.8e-28 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BQZ4 218 2.1e-16 Ral GTPase-activating protein subunit beta OS=Mus musculus GN=Ralgapb PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3652 Uncharacterized conserved protein Cluster-8309.62098 BP_3 1.00 2.87 282 -- -- -- -- -- 675698435 XM_003808722.2 282 1.97127e-144 PREDICTED: Pan paniscus lysozyme (LYZ), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62104 BP_3 4.00 1.30 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6211 BP_3 16.00 0.35 2483 807019652 XP_012163003.1 264 3.9e-20 PREDICTED: Down syndrome cell adhesion molecule-like protein Dscam2 [Ceratitis capitata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62110 BP_3 59.59 0.92 3418 815896315 XP_012246840.1 694 7.5e-70 PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896317|ref|XP_012246847.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896319|ref|XP_012246857.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- P19217 395 1.4e-36 Estrogen sulfotransferase OS=Bos taurus GN=SULT1E1 PE=1 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.62111 BP_3 4.00 0.39 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62117 BP_3 8.06 0.95 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62118 BP_3 21.18 1.88 836 91084177 XP_966649.1 669 1.4e-67 PREDICTED: GPN-loop GTPase 1 [Tribolium castaneum]>gi|270008775|gb|EFA05223.1| hypothetical protein TcasGA2_TC015364 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9HCN4 477 1.1e-46 GPN-loop GTPase 1 OS=Homo sapiens GN=GPN1 PE=1 SV=1 PF00025//PF06512 ADP-ribosylation factor family//Sodium ion transport-associated GO:0006814 sodium ion transport GO:0005525//GO:0005248 GTP binding//voltage-gated sodium channel activity GO:0001518 voltage-gated sodium channel complex KOG1532 GTPase XAB1, interacts with DNA repair protein XPA Cluster-8309.62120 BP_3 30.00 2.66 836 74844658 Q95V34.1 1055 2.5e-112 RecName: Full=40S ribosomal protein S4 [Spodoptera frugiperda]>gi|16566725|gb|AAL26580.1|AF429978_1 ribosomal protein S4 [Spodoptera frugiperda] 262401340 FJ774852.1 439 0 Scylla paramamosain ribosomal protein S4 mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 1055 1.0e-113 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.62121 BP_3 10.00 0.59 1113 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62123 BP_3 5.00 1.45 457 645006679 XP_008204884.1 160 8.3e-09 PREDICTED: orexin receptor type 1-like isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62127 BP_3 55.53 1.69 1875 642918767 XP_008191575.1 1211 4.6e-130 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9MYY0 715 6.2e-74 Heparanase OS=Bos taurus GN=HPSE PE=2 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.6213 BP_3 5.05 0.42 871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643//PF07776 B-box zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005622//GO:0005634 intracellular//nucleus -- -- Cluster-8309.62137 BP_3 1.00 2.80 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62141 BP_3 3.00 0.36 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62146 BP_3 11.88 0.94 901 478252437 ENN72860.1 385 1.3e-34 hypothetical protein YQE_10509, partial [Dendroctonus ponderosae]>gi|546673468|gb|ERL85066.1| hypothetical protein D910_02489 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01292 Prokaryotic cytochrome b561 GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane -- -- Cluster-8309.6216 BP_3 82.58 0.84 5022 478257469 ENN77625.1 996 1.0e-104 hypothetical protein YQE_05919, partial [Dendroctonus ponderosae]>gi|546679863|gb|ERL90251.1| hypothetical protein D910_07603 [Dendroctonus ponderosae] -- -- -- -- -- K11502 CENPJ centromere protein J http://www.genome.jp/dbget-bin/www_bget?ko:K11502 Q5BQN8 469 5.6e-45 Centromere protein J OS=Pan troglodytes GN=CENPJ PE=2 SV=1 PF02531//PF00170//PF04136//PF05531//PF16331//PF01395//PF06305 PsaD//bZIP transcription factor//Sec34-like family//Nucleopolyhedrovirus P10 protein//TolA binding protein trimerisation//PBP/GOBP family//Protein of unknown function (DUF1049) GO:0006355//GO:0006886//GO:0070206//GO:0015979 regulation of transcription, DNA-templated//intracellular protein transport//protein trimerization//photosynthesis GO:0003700//GO:0043565//GO:0005549 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//odorant binding GO:0005801//GO:0016020//GO:0009538//GO:0005667//GO:0009522//GO:0005887//GO:0019028 cis-Golgi network//membrane//photosystem I reaction center//transcription factor complex//photosystem I//integral component of plasma membrane//viral capsid -- -- Cluster-8309.62161 BP_3 13.22 0.42 1816 91077324 XP_974759.1 487 4.0e-46 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270001669|gb|EEZ98116.1| hypothetical protein TcasGA2_TC000534 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 P17817 303 3.6e-26 Pyrroline-5-carboxylate reductase OS=Glycine max PE=2 SV=1 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006561//GO:0006098//GO:0006525//GO:0055114//GO:0019521 proline biosynthetic process//pentose-phosphate shunt//arginine metabolic process//oxidation-reduction process//D-gluconate metabolic process GO:0004735//GO:0000166//GO:0004616 pyrroline-5-carboxylate reductase activity//nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.62170 BP_3 6.00 0.32 1194 675366783 KFM59685.1 268 6.5e-21 hypothetical protein X975_13894, partial [Stegodyphus mimosarum] -- -- -- -- -- K08867 WNK, PRKWNK WNK lysine deficient protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62181 BP_3 3.10 0.48 604 546679552 ERL90000.1 563 2.0e-55 hypothetical protein D910_07359 [Dendroctonus ponderosae] -- -- -- -- -- K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 Q8CGC7 460 7.4e-45 Bifunctional glutamate/proline--tRNA ligase OS=Mus musculus GN=Eprs PE=1 SV=4 PF00458 WHEP-TRS domain GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0004812 ATP binding//aminoacyl-tRNA ligase activity -- -- KOG4163 Prolyl-tRNA synthetase Cluster-8309.62182 BP_3 4.36 0.42 790 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62189 BP_3 19.26 0.98 1239 478258272 ENN78401.1 311 7.0e-26 hypothetical protein YQE_05201, partial [Dendroctonus ponderosae]>gi|546683474|gb|ERL93280.1| hypothetical protein D910_10576 [Dendroctonus ponderosae] -- -- -- -- -- K15151 MED10, NUT2 mediator of RNA polymerase II transcription subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K15151 Q7Q5R5 273 7.3e-23 Mediator of RNA polymerase II transcription subunit 10 OS=Anopheles gambiae GN=MED10 PE=3 SV=2 PF09748 Transcription factor subunit Med10 of Mediator complex GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3046 Transcription factor, subunit of SRB subcomplex of RNA polymerase II Cluster-8309.6219 BP_3 7.00 3.34 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.622 BP_3 486.89 120.66 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02038//PF01771 ATP1G1/PLM/MAT8 family//Herpesvirus alkaline exonuclease GO:0006811 ion transport GO:0005216//GO:0004527//GO:0003677 ion channel activity//exonuclease activity//DNA binding GO:0016020 membrane -- -- Cluster-8309.62202 BP_3 16.92 3.05 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04901 Receptor activity modifying family GO:0006886//GO:0015031//GO:0008277 intracellular protein transport//protein transport//regulation of G-protein coupled receptor protein signaling pathway GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.62205 BP_3 8.00 0.31 1526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62212 BP_3 15.12 0.53 1673 189241520 XP_968500.2 471 2.6e-44 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 375 1.5e-34 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.62215 BP_3 279.42 6.73 2294 642923025 XP_008200500.1 1852 2.6e-204 PREDICTED: protein eyes shut [Tribolium castaneum]>gi|270006587|gb|EFA03035.1| hypothetical protein TcasGA2_TC010461 [Tribolium castaneum] -- -- -- -- -- K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 A0A1F4 1181 7.0e-128 Protein eyes shut OS=Drosophila melanogaster GN=eys PE=1 SV=1 PF01725//PF07645//PF00008 Ham1 family//Calcium-binding EGF domain//EGF-like domain -- -- GO:0005509//GO:0016787//GO:0005515 calcium ion binding//hydrolase activity//protein binding -- -- -- -- Cluster-8309.62218 BP_3 1.00 0.88 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62219 BP_3 2.04 0.49 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62220 BP_3 15.96 0.87 1178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62227 BP_3 14.54 0.46 1820 546679463 ERL89927.1 545 7.5e-53 hypothetical protein D910_07286 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O95425 294 3.9e-25 Supervillin OS=Homo sapiens GN=SVIL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62232 BP_3 9.00 1.02 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.62233 BP_3 57.14 0.53 5502 641659180 XP_008180990.1 864 2.3e-89 PREDICTED: uncharacterized protein LOC103308761 [Acyrthosiphon pisum] 759064428 XM_011343316.1 62 8.57303e-21 PREDICTED: Cerapachys biroi uncharacterized LOC105281809 (LOC105281809), mRNA -- -- -- -- Q96DM1 176 5.7e-11 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF14777//PF04827 Cilia BBSome complex subunit 10//Plant transposon protein GO:0042384 cilium assembly GO:0016788 hydrolase activity, acting on ester bonds GO:0034464 BBSome -- -- Cluster-8309.62234 BP_3 21.00 2.14 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6224 BP_3 5.00 0.35 985 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62241 BP_3 3.00 1.63 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62265 BP_3 4.00 1.49 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62268 BP_3 11.00 0.73 1021 871234007 XP_012938222.1 186 1.8e-11 PREDICTED: protein wos2 isoform X3 [Aplysia californica] 697083755 XM_009656668.1 696 0 Verticillium dahliae VdLs.17 wos2 partial mRNA -- -- -- -- Q11118 233 2.6e-18 Protein wos2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=wos2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3158 HSP90 co-chaperone p23 Cluster-8309.62271 BP_3 3.00 1.15 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62272 BP_3 10.69 0.83 911 478250014 ENN70520.1 310 6.7e-26 hypothetical protein YQE_12696, partial [Dendroctonus ponderosae]>gi|546683174|gb|ERL93018.1| hypothetical protein D910_10320 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H8Y5 150 9.8e-09 Ankyrin repeat and zinc finger domain-containing protein 1 OS=Homo sapiens GN=ANKZF1 PE=1 SV=1 PF13606//PF01080//PF00023 Ankyrin repeat//Presenilin//Ankyrin repeat -- -- GO:0004190//GO:0005515 aspartic-type endopeptidase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.62277 BP_3 123.33 1.13 5537 189237499 XP_971802.2 3233 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007691|gb|EFA04139.1| hypothetical protein TcasGA2_TC014383 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1139 1.2e-122 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF03193//PF06414//PF00931//PF01580//PF08477//PF00664//PF01350//PF01443//PF13304//PF01926//PF00437 ABC transporter//Protein of unknown function, DUF258//Zeta toxin//NB-ARC domain//FtsK/SpoIIIE family//Ras of Complex, Roc, domain of DAPkinase//ABC transporter transmembrane region//Flavivirus non-structural protein NS4A//Viral (Superfamily 1) RNA helicase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein GO:0055085//GO:0006810//GO:0016032//GO:0016070//GO:0007264 transmembrane transport//transport//viral process//RNA metabolic process//small GTPase mediated signal transduction GO:0005524//GO:0003924//GO:0000166//GO:0016887//GO:0016301//GO:0042626//GO:0003677//GO:0043531//GO:0005525//GO:0017111 ATP binding//GTPase activity//nucleotide binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//DNA binding//ADP binding//GTP binding//nucleoside-triphosphatase activity GO:0016021//GO:0019012 integral component of membrane//virion -- -- Cluster-8309.62279 BP_3 38.80 0.47 4278 642923652 XP_971908.2 2636 6.1e-295 PREDICTED: uncharacterized protein LOC660599 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1139 9.6e-123 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF03193//PF06414//PF01580//PF00931//PF08477//PF00664//PF01443//PF13304//PF01926//PF00437 ABC transporter//Protein of unknown function, DUF258//Zeta toxin//FtsK/SpoIIIE family//NB-ARC domain//Ras of Complex, Roc, domain of DAPkinase//ABC transporter transmembrane region//Viral (Superfamily 1) RNA helicase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein GO:0055085//GO:0006810//GO:0007264 transmembrane transport//transport//small GTPase mediated signal transduction GO:0003677//GO:0005524//GO:0003924//GO:0043531//GO:0016301//GO:0016887//GO:0005525//GO:0000166//GO:0042626 DNA binding//ATP binding//GTPase activity//ADP binding//kinase activity//ATPase activity//GTP binding//nucleotide binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.62282 BP_3 41.29 0.73 3030 91086047 XP_973605.1 3516 0.0e+00 PREDICTED: protein turtle homolog B [Tribolium castaneum] 642927616 XM_968512.2 548 0 PREDICTED: Tribolium castaneum protein turtle homolog B (LOC662415), mRNA -- -- -- -- Q9R044 237 2.7e-18 Nephrin OS=Rattus norvegicus GN=Nphs1 PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62283 BP_3 25.89 1.01 1533 546684831 ERL94413.1 661 2.2e-66 hypothetical protein D910_11691 [Dendroctonus ponderosae] -- -- -- -- -- K01719 hemD, UROS uroporphyrinogen-III synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01719 P51163 305 1.8e-26 Uroporphyrinogen-III synthase OS=Mus musculus GN=Uros PE=2 SV=1 PF02602//PF11380 Uroporphyrinogen-III synthase HemD//Stealth protein CR2, conserved region 2 GO:0033014//GO:0006783//GO:0015994 tetrapyrrole biosynthetic process//heme biosynthetic process//chlorophyll metabolic process GO:0004852//GO:0016772 uroporphyrinogen-III synthase activity//transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.62284 BP_3 6.37 0.64 771 642940071 XP_968576.3 545 3.2e-53 PREDICTED: protein HIRA-like [Tribolium castaneum]>gi|270015980|gb|EFA12428.1| hypothetical protein TcasGA2_TC001683 [Tribolium castaneum] -- -- -- -- -- K11293 HIRA, HIR1 protein HIRA/HIR1 http://www.genome.jp/dbget-bin/www_bget?ko:K11293 Q61666 381 1.4e-35 Protein HIRA OS=Mus musculus GN=Hira PE=1 SV=3 PF01283//PF00400 Ribosomal protein S26e//WD domain, G-beta repeat GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0973 Histone transcription regulator HIRA, WD repeat superfamily Cluster-8309.62288 BP_3 7.00 0.60 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62289 BP_3 74.30 6.40 851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6229 BP_3 140.00 3.62 2157 270006939 EFA03387.1 211 4.8e-14 hypothetical protein TcasGA2_TC013373 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.62290 BP_3 58.00 1.30 2442 821002415 XP_012364883.1 319 1.6e-26 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 729-like [Nomascus leucogenys] 692923170 KM418754.1 177 4.45584e-85 Chalybion californicum isolate 6759cha ultra conserved element locus uce-90 genomic sequence -- -- -- -- Q86T29 304 3.7e-26 Zinc finger protein 605 OS=Homo sapiens GN=ZNF605 PE=2 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.62295 BP_3 11.97 1.55 663 795010872 XP_011869493.1 530 1.5e-51 PREDICTED: uncharacterized protein LOC105562922, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62304 BP_3 34.28 0.40 4385 646718427 KDR20897.1 3211 0.0e+00 WD repeat-containing protein 35 [Zootermopsis nevadensis] 780035245 XM_778124.4 37 5.38614e-07 PREDICTED: Strongylocentrotus purpuratus WD repeat-containing protein 35 (LOC577925), transcript variant X3, mRNA -- -- -- -- A6N6J5 2903 0.0e+00 WD repeat-containing protein 35 OS=Rattus norvegicus GN=Wdr35 PE=1 SV=1 PF13181//PF00637//PF04053 Tetratricopeptide repeat//Region in Clathrin and VPS//Coatomer WD associated region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG2503 Tubby superfamily protein TULP4 Cluster-8309.62308 BP_3 12.61 0.64 1247 478255012 ENN75245.1 463 1.7e-43 hypothetical protein YQE_08254, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28DS0 177 1.0e-11 SUMO-activating enzyme subunit 1 OS=Xenopus tropicalis GN=sae1 PE=2 SV=1 PF00899 ThiF family -- -- GO:0008641 small protein activating enzyme activity -- -- -- -- Cluster-8309.62310 BP_3 2.15 0.39 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62312 BP_3 16.51 0.32 2802 641664521 XP_008183038.1 883 7.4e-92 PREDICTED: uncharacterized protein LOC103309427 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14736//PF08040 Protein N-terminal asparagine amidohydrolase//MNLL subunit GO:0006528//GO:0006118 asparagine metabolic process//obsolete electron transport GO:0008418//GO:0003954 protein-N-terminal asparagine amidohydrolase activity//NADH dehydrogenase activity GO:0005739 mitochondrion -- -- Cluster-8309.62314 BP_3 78.52 1.56 2723 91077390 XP_975277.1 1642 7.0e-180 PREDICTED: chromatin assembly factor 1 subunit B [Tribolium castaneum]>gi|270001646|gb|EEZ98093.1| hypothetical protein TcasGA2_TC000506 [Tribolium castaneum] -- -- -- -- -- K10751 CHAF1B chromatin assembly factor 1 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10751 Q13112 845 7.6e-89 Chromatin assembly factor 1 subunit B OS=Homo sapiens GN=CHAF1B PE=1 SV=1 PF10584//PF00400//PF01336 Proteasome subunit A N-terminal signature//WD domain, G-beta repeat//OB-fold nucleic acid binding domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515//GO:0004175//GO:0003676 protein binding//endopeptidase activity//nucleic acid binding GO:0019773 proteasome core complex, alpha-subunit complex KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats) Cluster-8309.62315 BP_3 146.48 2.84 2776 91077390 XP_975277.1 1616 7.4e-177 PREDICTED: chromatin assembly factor 1 subunit B [Tribolium castaneum]>gi|270001646|gb|EEZ98093.1| hypothetical protein TcasGA2_TC000506 [Tribolium castaneum] -- -- -- -- -- K10751 CHAF1B chromatin assembly factor 1 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10751 Q13112 816 1.8e-85 Chromatin assembly factor 1 subunit B OS=Homo sapiens GN=CHAF1B PE=1 SV=1 PF00400//PF10584 WD domain, G-beta repeat//Proteasome subunit A N-terminal signature GO:0006511 ubiquitin-dependent protein catabolic process GO:0004175//GO:0005515 endopeptidase activity//protein binding GO:0019773 proteasome core complex, alpha-subunit complex KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats) Cluster-8309.6232 BP_3 14.43 1.75 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62324 BP_3 14.73 1.07 953 332372560 AEE61422.1 762 2.7e-78 unknown [Dendroctonus ponderosae]>gi|478257372|gb|ENN77530.1| hypothetical protein YQE_05978, partial [Dendroctonus ponderosae]>gi|546685343|gb|ERL94870.1| hypothetical protein D910_12143 [Dendroctonus ponderosae] -- -- -- -- -- K10687 UBE2F ubiquitin-conjugating enzyme E2 F http://www.genome.jp/dbget-bin/www_bget?ko:K10687 Q5ZKX6 537 1.4e-53 NEDD8-conjugating enzyme UBE2F OS=Gallus gallus GN=UBE2F PE=2 SV=1 PF08001 CMV US GO:0030683 evasion or tolerance by virus of host immune response -- -- GO:0044386 integral to host endoplasmic reticulum membrane KOG0420 Ubiquitin-protein ligase Cluster-8309.62325 BP_3 67.74 0.69 5018 332372560 AEE61422.1 791 6.2e-81 unknown [Dendroctonus ponderosae]>gi|478257372|gb|ENN77530.1| hypothetical protein YQE_05978, partial [Dendroctonus ponderosae]>gi|546685343|gb|ERL94870.1| hypothetical protein D910_12143 [Dendroctonus ponderosae] -- -- -- -- -- K10687 UBE2F ubiquitin-conjugating enzyme E2 F http://www.genome.jp/dbget-bin/www_bget?ko:K10687 Q5M8Y2 566 3.1e-56 NEDD8-conjugating enzyme UBE2F OS=Xenopus tropicalis GN=ube2f PE=2 SV=1 PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0005737//GO:0016020 cytoplasm//membrane KOG0420 Ubiquitin-protein ligase Cluster-8309.62326 BP_3 41.22 0.42 5051 332372560 AEE61422.1 791 6.2e-81 unknown [Dendroctonus ponderosae]>gi|478257372|gb|ENN77530.1| hypothetical protein YQE_05978, partial [Dendroctonus ponderosae]>gi|546685343|gb|ERL94870.1| hypothetical protein D910_12143 [Dendroctonus ponderosae] -- -- -- -- -- K10687 UBE2F ubiquitin-conjugating enzyme E2 F http://www.genome.jp/dbget-bin/www_bget?ko:K10687 Q5M8Y2 566 3.2e-56 NEDD8-conjugating enzyme UBE2F OS=Xenopus tropicalis GN=ube2f PE=2 SV=1 PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0016020//GO:0005737 membrane//cytoplasm KOG0420 Ubiquitin-protein ligase Cluster-8309.62327 BP_3 8.00 0.46 1138 672889444 BAP28201.1 556 2.5e-54 copper/zinc superoxide dismutase isoform 2 [Marsupenaeus japonicus] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 396 3.7e-37 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF08925//PF00080 Domain of Unknown Function (DUF1907)//Copper/zinc superoxide dismutase (SODC) GO:0006801//GO:0055114 superoxide metabolic process//oxidation-reduction process GO:0046872 metal ion binding GO:0005634 nucleus KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.62331 BP_3 22.00 0.55 2221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62334 BP_3 2.00 0.47 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62341 BP_3 24.00 4.81 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6235 BP_3 26.80 0.33 4216 478251160 ENN71636.1 2129 3.7e-236 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843//PF17001//PF01665 Herpesvirus tegument protein, N-terminal conserved region//Type III secretion basal body protein I, YscI, HrpB, PscI//Rotavirus non-structural protein NSP3 GO:0006508//GO:0009306 proteolysis//protein secretion GO:0003723//GO:0008233 RNA binding//peptidase activity -- -- -- -- Cluster-8309.62351 BP_3 2.00 0.31 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62354 BP_3 18.00 0.57 1812 642917767 XP_008191359.1 1321 7.8e-143 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 821 3.0e-86 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF05199//PF02254 GMC oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0006813//GO:0055114 potassium ion transport//oxidation-reduction process GO:0016614//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.62356 BP_3 9.57 1.34 636 546683633 ERL93421.1 257 6.5e-20 hypothetical protein D910_10713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62357 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62361 BP_3 2.00 0.34 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6237 BP_3 1.00 0.32 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62374 BP_3 2.00 0.70 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6238 BP_3 1.00 0.43 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62391 BP_3 12.62 0.51 1496 211922673 BAG80981.1 1128 1.5e-120 opsin [Triops longicaudatus] 755873530 XM_005182926.2 34 8.42103e-06 PREDICTED: Musca domestica opsin Rh1-like (LOC101898316), mRNA K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25158 936 1.2e-99 Compound eye opsin BCRH2 OS=Hemigrapsus sanguineus PE=2 SV=1 PF04911//PF00001 ATP synthase j chain//7 transmembrane receptor (rhodopsin family) GO:0015992//GO:0015986//GO:0007186 proton transport//ATP synthesis coupled proton transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0015078 G-protein coupled receptor activity//hydrogen ion transmembrane transporter activity GO:0045263//GO:0016021 proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.62394 BP_3 186.05 1.92 4956 189237952 XP_001813626.1 2230 8.4e-248 PREDICTED: methyltransferase-like protein 13 [Tribolium castaneum]>gi|270008036|gb|EFA04484.1| hypothetical protein TcasGA2_TC014789 [Tribolium castaneum] 332372815 BT126586.1 117 2.05636e-51 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q9VIK9 1576 2.4e-173 Methyltransferase-like protein 13 OS=Drosophila melanogaster GN=CG2614 PE=2 SV=1 PF01209//PF00484//PF04670//PF00071//PF10662//PF00005//PF03193//PF07516//PF08241//PF05175//PF05724//PF00503//PF00025//PF02390//PF08477//PF01926 ubiE/COQ5 methyltransferase family//Carbonic anhydrase//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//ABC transporter//Protein of unknown function, DUF258//SecA Wing and Scaffold domain//Methyltransferase domain//Methyltransferase small domain//Thiopurine S-methyltransferase (TPMT)//G-protein alpha subunit//ADP-ribosylation factor family//Putative methyltransferase//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0009451//GO:0007264//GO:0032259//GO:0006400//GO:0006807//GO:0006576//GO:0008152//GO:0006730//GO:0007186//GO:0008033//GO:0007165//GO:0017038 RNA modification//small GTPase mediated signal transduction//methylation//tRNA modification//nitrogen compound metabolic process//cellular biogenic amine metabolic process//metabolic process//one-carbon metabolic process//G-protein coupled receptor signaling pathway//tRNA processing//signal transduction//protein import GO:0005525//GO:0004871//GO:0008176//GO:0008757//GO:0004089//GO:0008270//GO:0008168//GO:0019001//GO:0016887//GO:0005524//GO:0031683//GO:0003924 GTP binding//signal transducer activity//tRNA (guanine-N7-)-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//carbonate dehydratase activity//zinc ion binding//methyltransferase activity//guanyl nucleotide binding//ATPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0016020 membrane KOG3886 GTP-binding protein Cluster-8309.62414 BP_3 2.95 0.60 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62415 BP_3 8.13 0.49 1094 270005481 EFA01929.1 273 1.6e-21 hypothetical protein TcasGA2_TC007543 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62419 BP_3 6.00 0.35 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62421 BP_3 40.87 1.21 1917 189239087 XP_968222.2 1883 5.6e-208 PREDICTED: DNA polymerase epsilon subunit 2 [Tribolium castaneum] -- -- -- -- -- K02325 POLE2 DNA polymerase epsilon subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02325 Q5ZKQ6 1029 2.5e-110 DNA polymerase epsilon subunit 2 OS=Gallus gallus GN=POLE2 PE=2 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG3818 DNA polymerase epsilon, subunit B Cluster-8309.62424 BP_3 65.95 1.83 2025 189239087 XP_968222.2 852 2.1e-88 PREDICTED: DNA polymerase epsilon subunit 2 [Tribolium castaneum] -- -- -- -- -- K02325 POLE2 DNA polymerase epsilon subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02325 P56282 534 6.5e-53 DNA polymerase epsilon subunit 2 OS=Homo sapiens GN=POLE2 PE=1 SV=2 PF04042//PF05132 DNA polymerase alpha/epsilon subunit B//RNA polymerase III RPC4 GO:0006144//GO:0006383//GO:0006351//GO:0006206//GO:0006260 purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//pyrimidine nucleobase metabolic process//DNA replication GO:0003887//GO:0003899//GO:0003677 DNA-directed DNA polymerase activity//DNA-directed RNA polymerase activity//DNA binding GO:0042575//GO:0005730//GO:0005666 DNA polymerase complex//nucleolus//DNA-directed RNA polymerase III complex KOG3818 DNA polymerase epsilon, subunit B Cluster-8309.62426 BP_3 3.00 3.89 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62429 BP_3 4.00 0.69 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62430 BP_3 8.07 0.33 1474 91090910 XP_973922.1 1099 3.5e-117 PREDICTED: protein rogdi isoform X1 [Tribolium castaneum]>gi|270013221|gb|EFA09669.1| hypothetical protein TcasGA2_TC011795 [Tribolium castaneum] 805780431 XM_012283623.1 73 1.73299e-27 PREDICTED: Megachile rotundata protein rogdi (LOC100879337), transcript variant X2, mRNA -- -- -- -- Q9VVE2 802 4.0e-84 Protein rogdi OS=Drosophila melanogaster GN=rogdi PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3992 Uncharacterized conserved protein Cluster-8309.62434 BP_3 16.49 0.34 2658 6682321 CAB64663.1 211 5.9e-14 pedal retractor muscle myosin heavy chain [Mytilus galloprovincialis] -- -- -- -- -- -- -- -- -- P24733 186 1.9e-12 Myosin heavy chain, striated muscle OS=Argopecten irradians PE=1 SV=1 PF08912 Rho Binding -- -- GO:0017048 Rho GTPase binding -- -- KOG0161 Myosin class II heavy chain Cluster-8309.62439 BP_3 32.73 0.43 3966 642918256 XP_008191433.1 1117 7.7e-119 PREDICTED: low affinity cationic amino acid transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.62440 BP_3 9.40 0.37 1503 642919375 XP_008191845.1 457 9.9e-43 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PUF6 190 3.7e-13 Platelet-derived growth factor receptor alpha OS=Gallus gallus GN=PDGFRA PE=2 SV=1 PF13895//PF05790 Immunoglobulin domain//Immunoglobulin C2-set domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.62441 BP_3 26.93 0.98 1615 642915291 XP_008190557.1 364 6.5e-32 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8VI02 160 1.2e-09 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Rattus norvegicus GN=Ppp4r1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62442 BP_3 2.00 0.31 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62443 BP_3 5.00 0.52 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62445 BP_3 23.75 1.11 1324 642923667 XP_008193834.1 897 8.3e-94 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 685 1.3e-70 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF05136 Phage portal protein, lambda family GO:0019068 virion assembly GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.62452 BP_3 2.00 0.38 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62456 BP_3 80.00 0.51 7794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62457 BP_3 19.00 0.41 2532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62460 BP_3 6.36 0.49 916 478263265 ENN81649.1 429 1.1e-39 hypothetical protein YQE_01947, partial [Dendroctonus ponderosae]>gi|546673294|gb|ERL84926.1| hypothetical protein D910_02349 [Dendroctonus ponderosae] 817053829 XM_012408690.1 44 1.40395e-11 PREDICTED: Athalia rosae CD63 antigen-like (LOC105690669), mRNA K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 P30409 155 2.6e-09 CD9 antigen OS=Chlorocebus aethiops GN=CD9 PE=2 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.62467 BP_3 6.13 0.42 1001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62470 BP_3 4.07 1.43 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.62478 BP_3 2.00 2.50 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62479 BP_3 3.00 1.56 382 54042606 AAV28476.1 272 7.1e-22 arthrodial cuticle protein AMP8.1 [Callinectes sapidus] -- -- -- -- -- -- -- -- -- P81576 287 5.4e-25 Cuticle protein AM1159 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.62482 BP_3 3.00 0.45 615 675370311 KFM63213.1 248 7.0e-19 Enterin neuropeptide, partial [Stegodyphus mimosarum] -- -- -- -- -- K14713 SLC39A7, KE4, ZIP7 solute carrier family 39 (zinc transporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14713 B3QGJ9 140 9.6e-08 Urease accessory protein UreE OS=Rhodopseudomonas palustris (strain TIE-1) GN=ureE PE=3 SV=1 PF04879 Molybdopterin oxidoreductase Fe4S4 domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.62483 BP_3 115.81 3.47 1902 546676744 ERL87700.1 844 1.7e-87 hypothetical protein D910_05090 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBA8 407 3.3e-38 DTW domain-containing protein 2 OS=Homo sapiens GN=DTWD2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62486 BP_3 2.00 0.66 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62489 BP_3 104.79 2.56 2265 641652704 XP_008178503.1 754 5.4e-77 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- O96006 254 2.1e-20 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 PF05699//PF02267//PF14372 hAT family C-terminal dimerisation region//ADP-ribosyl cyclase//Domain of unknown function (DUF4413) GO:0006769//GO:0046497 nicotinamide metabolic process//nicotinate nucleotide metabolic process GO:0046983//GO:0003953//GO:0003677 protein dimerization activity//NAD+ nucleosidase activity//DNA binding -- -- KOG1121 Tam3-transposase (Ac family) Cluster-8309.6249 BP_3 144.68 2.05 3687 642937648 XP_966362.2 1156 2.2e-123 PREDICTED: uncharacterized protein LOC654853 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VEE6 179 1.7e-11 Zinc finger protein 800 OS=Mus musculus GN=Znf800 PE=1 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.62492 BP_3 8.60 0.35 1469 478251892 ENN72330.1 815 3.0e-84 hypothetical protein YQE_10965, partial [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 A2AHJ4 644 8.3e-66 Bromodomain and WD repeat-containing protein 3 OS=Mus musculus GN=Brwd3 PE=2 SV=1 PF04889//PF06507//PF10717 Cwf15/Cwc15 cell cycle control protein//Auxin response factor//Occlusion-derived virus envelope protein ODV-E18 GO:0006355//GO:0009725//GO:0000398 regulation of transcription, DNA-templated//response to hormone//mRNA splicing, via spliceosome GO:0003677 DNA binding GO:0005634//GO:0005681//GO:0019031 nucleus//spliceosomal complex//viral envelope KOG0644 Uncharacterized conserved protein, contains WD40 repeat and BROMO domains Cluster-8309.62493 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62497 BP_3 6.39 0.75 705 91093076 XP_968784.1 211 1.6e-14 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1HRV8 162 3.1e-10 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF04453//PF02577 Organic solvent tolerance protein//Bifunctional nuclease GO:0010033//GO:0061024 response to organic substance//membrane organization GO:0004518 nuclease activity GO:0016021//GO:0019867 integral component of membrane//outer membrane -- -- Cluster-8309.62498 BP_3 3.00 0.42 635 -- -- -- -- -- 642916516 XM_008192852.1 48 5.71701e-14 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.625 BP_3 1.00 0.64 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62503 BP_3 2.00 0.32 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62517 BP_3 32.00 1.11 1676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006814//GO:0006090//GO:0071436//GO:0006525//GO:0006560 sodium ion transport//pyruvate metabolic process//sodium ion export//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.62520 BP_3 9.00 0.35 1538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62531 BP_3 77.22 1.91 2244 270001349 EEZ97796.1 874 6.6e-91 hypothetical protein TcasGA2_TC000158 [Tribolium castaneum] -- -- -- -- -- K06947 GRC3, NOL9 polynucleotide 5'-hydroxyl-kinase GRC3/NOL9 http://www.genome.jp/dbget-bin/www_bget?ko:K06947 A1ZA92 357 2.4e-32 Polynucleotide 5'-hydroxyl-kinase NOL9 OS=Drosophila melanogaster GN=CG8414 PE=2 SV=1 PF01580//PF00005 FtsK/SpoIIIE family//ABC transporter -- -- GO:0005524//GO:0000166//GO:0016887//GO:0003677 ATP binding//nucleotide binding//ATPase activity//DNA binding -- -- KOG2750 Uncharacterized conserved protein similar to ATP/GTP-binding protein Cluster-8309.62536 BP_3 4.00 1.01 483 478255955 ENN76156.1 576 5.0e-57 hypothetical protein YQE_07327, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V7T8 279 5.7e-24 Ropporin-1-like protein OS=Xenopus laevis GN=ropn1l PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62537 BP_3 12.98 0.80 1076 546675648 ERL86798.1 334 1.3e-28 hypothetical protein D910_04203 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V7T8 132 1.4e-06 Ropporin-1-like protein OS=Xenopus laevis GN=ropn1l PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6254 BP_3 12.00 1.56 662 728416619 AIY68316.1 145 6.6e-07 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04960 Glutaminase GO:0006541 glutamine metabolic process GO:0004359 glutaminase activity -- -- -- -- Cluster-8309.62545 BP_3 16.54 1.15 983 642910515 XP_971774.3 323 2.2e-27 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02924//PF06667 Bacteriophage lambda head decoration protein D//Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- GO:0019028 viral capsid -- -- Cluster-8309.62547 BP_3 74.32 1.08 3598 642910641 XP_008200040.1 1253 1.2e-134 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 253 3.72258e-127 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q5R803 630 8.5e-64 FERM domain-containing protein 3 OS=Pongo abelii GN=FRMD3 PE=2 SV=1 PF01676 Metalloenzyme superfamily -- -- GO:0046872//GO:0003824//GO:0008092 metal ion binding//catalytic activity//cytoskeletal protein binding GO:0005737//GO:0005856//GO:0019898 cytoplasm//cytoskeleton//extrinsic component of membrane KOG3530 FERM domain protein EHM2 Cluster-8309.62549 BP_3 33.80 1.04 1861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6255 BP_3 9.00 0.71 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62550 BP_3 11.00 0.66 1099 795010007 XP_011864749.1 550 1.2e-53 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62554 BP_3 14.00 0.72 1229 642931348 XP_008196540.1 171 1.2e-09 PREDICTED: uncharacterized protein LOC662455 [Tribolium castaneum]>gi|642931350|ref|XP_008196541.1| PREDICTED: uncharacterized protein LOC662455 [Tribolium castaneum]>gi|642931352|ref|XP_008196542.1| PREDICTED: uncharacterized protein LOC662455 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62555 BP_3 28.54 4.09 628 91089491 XP_969723.1 538 1.7e-52 PREDICTED: U6 snRNA-associated Sm-like protein LSm7 [Tribolium castaneum] -- -- -- -- -- K12626 LSM7 U6 snRNA-associated Sm-like protein LSm7 http://www.genome.jp/dbget-bin/www_bget?ko:K12626 Q9UK45 433 1.0e-41 U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens GN=LSM7 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1781 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.62557 BP_3 1.00 0.32 443 478258579 ENN78643.1 230 6.1e-17 hypothetical protein YQE_04905, partial [Dendroctonus ponderosae] -- -- -- -- -- K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 175 6.0e-12 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3635 Phosphorylase kinase Cluster-8309.6256 BP_3 1.00 9.71 244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62561 BP_3 4.00 1.27 443 478257966 ENN78104.1 352 4.4e-31 hypothetical protein YQE_05258, partial [Dendroctonus ponderosae]>gi|546686101|gb|ERL95498.1| hypothetical protein D910_12760 [Dendroctonus ponderosae] -- -- -- -- -- K04819 HTR3 5-hydroxytryptamine receptor 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04819 P45963 178 2.7e-12 Acetylcholine receptor subunit alpha-type acr-7 OS=Caenorhabditis elegans GN=acr-7 PE=1 SV=2 PF02931 Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.62566 BP_3 59.40 1.22 2648 642926104 XP_008194786.1 555 7.6e-54 PREDICTED: uncharacterized protein LOC100141550 [Tribolium castaneum]>gi|270008534|gb|EFA04982.1| hypothetical protein TcasGA2_TC015060 [Tribolium castaneum] -- -- -- -- -- K12627 LSM8 U6 snRNA-associated Sm-like protein LSm8 http://www.genome.jp/dbget-bin/www_bget?ko:K12627 O95777 354 6.3e-32 U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens GN=LSM8 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1784 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.62573 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62574 BP_3 3.06 1.43 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62576 BP_3 4.00 0.90 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62581 BP_3 18.00 0.44 2257 193591726 XP_001944018.1 642 5.3e-64 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 194862332 XM_001969942.1 159 4.17198e-75 Drosophila erecta GG10387 (Dere\GG10387), mRNA -- -- -- -- Q96IR2 616 2.2e-62 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF13912//PF01363//PF16622//PF09606//PF00096//PF13465//PF00130 C2H2-type zinc finger//FYVE zinc finger//zinc-finger C2H2-type//ARC105 or Med15 subunit of Mediator complex non-fungal//Zinc finger, C2H2 type//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006357//GO:0035556 regulation of transcription from RNA polymerase II promoter//intracellular signal transduction GO:0001104//GO:0046872 RNA polymerase II transcription cofactor activity//metal ion binding GO:0016592 mediator complex -- -- Cluster-8309.62583 BP_3 49.91 0.47 5407 817193091 XP_012271999.1 243 2.3e-17 PREDICTED: actin-binding protein anillin-like isoform X1 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q801E2 187 3.0e-12 Actin-binding protein anillin OS=Xenopus laevis GN=anln PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62598 BP_3 7.00 0.36 1220 270017193 EFA13639.1 204 1.8e-13 hypothetical protein TcasGA2_TC005208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00527//PF02224 E7 protein, Early protein//Cytidylate kinase GO:0006206//GO:0006355//GO:0006139 pyrimidine nucleobase metabolic process//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process GO:0004127//GO:0003700//GO:0003677//GO:0005524 cytidylate kinase activity//transcription factor activity, sequence-specific DNA binding//DNA binding//ATP binding GO:0005667 transcription factor complex -- -- Cluster-8309.62599 BP_3 2.00 0.41 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62600 BP_3 4.00 0.68 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62601 BP_3 6.53 0.74 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62603 BP_3 30.19 0.74 2253 270016305 EFA12751.1 1179 2.8e-126 hypothetical protein TcasGA2_TC010278 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P16425 462 1.6e-44 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62607 BP_3 6.00 0.58 787 642925766 XP_008201663.1 165 3.8e-09 PREDICTED: uncharacterized protein LOC103315247 [Tribolium castaneum]>gi|270008624|gb|EFA05072.1| hypothetical protein TcasGA2_TC015169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62613 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62616 BP_3 9.08 0.91 775 195160665 XP_002021195.1 360 9.1e-32 GL24941 [Drosophila persimilis]>gi|194118308|gb|EDW40351.1| GL24941 [Drosophila persimilis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62618 BP_3 11.00 0.43 1537 170050469 XP_001861325.1 160 2.8e-08 conserved hypothetical protein [Culex quinquefasciatus]>gi|167872063|gb|EDS35446.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00688 TGF-beta propeptide GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity -- -- -- -- Cluster-8309.62621 BP_3 19.59 0.54 2051 478257290 ENN77453.1 1543 1.6e-168 hypothetical protein YQE_06277, partial [Dendroctonus ponderosae] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 942 3.2e-100 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.62626 BP_3 122.91 1.10 5678 642930391 XP_008196378.1 2389 3.5e-266 PREDICTED: uncharacterized protein LOC662968 isoform X1 [Tribolium castaneum]>gi|270010964|gb|EFA07412.1| serine protease P83 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 478 5.7e-46 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.62628 BP_3 2.00 0.42 519 270000947 EEZ97394.1 259 3.1e-20 hypothetical protein TcasGA2_TC011220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 167 6.0e-11 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.62633 BP_3 14.08 0.84 1097 91077892 XP_973098.1 308 1.4e-25 PREDICTED: glycerophosphodiester phosphodiesterase 1 [Tribolium castaneum]>gi|270002270|gb|EEZ98717.1| hypothetical protein TcasGA2_TC001263 [Tribolium castaneum] -- -- -- -- -- K19179 GDE1 glycerophosphoinositol glycerophosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19179 -- -- -- -- -- -- GO:0009395//GO:0006071//GO:0006629//GO:0046486 phospholipid catabolic process//glycerol metabolic process//lipid metabolic process//glycerolipid metabolic process GO:0008889 glycerophosphodiester phosphodiesterase activity -- -- -- -- Cluster-8309.62638 BP_3 2.00 0.40 531 820133310 KKX07404.1 204 7.6e-14 progestin and adipoQ receptor family member 6 isoform X3 [Scleropages formosus] -- -- -- -- -- -- -- -- -- Q6DC77 185 5.0e-13 Membrane progestin receptor gamma-B OS=Danio rerio GN=paqr5b PE=2 SV=1 PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.62648 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6266 BP_3 2.00 0.64 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01104 Bunyavirus non-structural protein NS-s GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.62666 BP_3 32.01 0.74 2389 270007206 EFA03654.1 2081 7.7e-231 hypothetical protein TcasGA2_TC013748 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q49B93 946 1.3e-100 Sodium-coupled monocarboxylate transporter 2 OS=Mus musculus GN=Slc5a12 PE=1 SV=1 PF09036//PF00474 Bcr-Abl oncoprotein oligomerisation domain//Sodium:solute symporter family GO:0055085//GO:0007165//GO:0006810//GO:0016310//GO:0009069//GO:0006468 transmembrane transport//signal transduction//transport//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005096//GO:0005215//GO:0004674 GTPase activator activity//transporter activity//protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.6267 BP_3 5.96 0.58 786 478251324 ENN71792.1 470 1.6e-44 hypothetical protein YQE_11526, partial [Dendroctonus ponderosae] -- -- -- -- -- K12590 RRP46, EXOSC5 exosome complex component RRP46 http://www.genome.jp/dbget-bin/www_bget?ko:K12590 Q9CRA8 253 9.6e-21 Exosome complex component RRP46 OS=Mus musculus GN=Exosc5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1069 Exosomal 3'-5' exoribonuclease complex, subunit Rrp46 Cluster-8309.62672 BP_3 80.31 0.95 4376 642917872 XP_969181.2 271 1.1e-20 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7B4 153 2.1e-08 Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens GN=SMYD3 PE=1 SV=4 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62675 BP_3 1.00 1.01 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62683 BP_3 6.43 0.54 866 91094103 XP_967297.1 897 5.5e-94 PREDICTED: trafficking protein particle complex subunit 13 [Tribolium castaneum]>gi|270010876|gb|EFA07324.1| hypothetical protein TcasGA2_TC015920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VFT9 644 4.9e-66 Trafficking protein particle complex subunit 13 OS=Xenopus tropicalis GN=trappc13 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2625 Uncharacterized conserved protein Cluster-8309.62688 BP_3 31.74 3.30 755 282400160 NP_001164203.1 1091 1.5e-116 cannonball [Tribolium castaneum]>gi|270008125|gb|EFA04573.1| cannonball [Tribolium castaneum] -- -- -- -- -- K03130 TAF5 transcription initiation factor TFIID subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03130 P49846 801 2.6e-84 Transcription initiation factor TFIID subunit 5 OS=Drosophila melanogaster GN=Taf5 PE=1 SV=1 PF00400 WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.62694 BP_3 1.00 2.34 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62696 BP_3 47.30 1.30 2039 332373444 AEE61863.1 459 7.9e-43 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 404 7.8e-38 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF01134//PF02558//PF00056//PF00070//PF03721//PF00899//PF13241//PF01266//PF03435//PF02254//PF01494//PF07992//PF02737//PF01399 Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//ThiF family//Putative NAD(P)-binding//FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//TrkA-N domain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//PCI domain GO:0006631//GO:0006552//GO:0018874//GO:0006633//GO:0019354//GO:0006813//GO:0006568//GO:0055114//GO:0006554//GO:0008033//GO:0006779//GO:0006574//GO:0006550//GO:0015940 fatty acid metabolic process//leucine catabolic process//benzoate metabolic process//fatty acid biosynthetic process//siroheme biosynthetic process//potassium ion transport//tryptophan metabolic process//oxidation-reduction process//lysine catabolic process//tRNA processing//porphyrin-containing compound biosynthetic process//valine catabolic process//isoleucine catabolic process//pantothenate biosynthetic process GO:0050660//GO:0008677//GO:0008641//GO:0043115//GO:0051287//GO:0016491//GO:0005515//GO:0003857//GO:0071949//GO:0016616 flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//small protein activating enzyme activity//precorrin-2 dehydrogenase activity//NAD binding//oxidoreductase activity//protein binding//3-hydroxyacyl-CoA dehydrogenase activity//FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.62697 BP_3 59.69 0.92 3435 728418700 AIY68378.1 792 3.2e-81 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 P16854 462 2.5e-44 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.62702 BP_3 8.24 0.53 1036 242006875 XP_002424269.1 214 1.0e-14 conserved hypothetical protein [Pediculus humanus corporis]>gi|212507651|gb|EEB11531.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- K14425 SLC12A1, NKCC2 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14425 Q25479 181 2.8e-12 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF03522 Solute carrier family 12 GO:0006811//GO:0006810 ion transport//transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.62707 BP_3 3.00 1.05 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62721 BP_3 3.00 0.92 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6273 BP_3 27.00 0.40 3506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62730 BP_3 4.37 0.45 761 270003050 EEZ99497.1 344 6.4e-30 hypothetical protein TcasGA2_TC000073 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF01176//PF16588 Zinc knuckle//Translation initiation factor 1A / IF-1//C2H2 zinc-finger GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003676//GO:0008270//GO:0003723 translation initiation factor activity//nucleic acid binding//zinc ion binding//RNA binding GO:0005840 ribosome -- -- Cluster-8309.62735 BP_3 4.00 0.54 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62741 BP_3 97.11 4.64 1301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04433 SWIRM domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62745 BP_3 3.00 2.05 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62751 BP_3 90.24 1.34 3532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62752 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62754 BP_3 9.00 0.34 1562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62769 BP_3 3.00 0.34 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62773 BP_3 25.08 2.59 759 478253884 ENN74176.1 311 4.3e-26 hypothetical protein YQE_09149, partial [Dendroctonus ponderosae]>gi|546684693|gb|ERL94310.1| hypothetical protein D910_11591 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5TYV4 152 4.8e-09 Spermatogenesis-defective protein 39 homolog OS=Danio rerio GN=vipas39 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62776 BP_3 13.00 0.94 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00942 Cellulose binding domain GO:0005975 carbohydrate metabolic process GO:0030248 cellulose binding -- -- -- -- Cluster-8309.62782 BP_3 1.00 0.51 384 642929105 XP_001810643.2 155 2.7e-08 PREDICTED: uncharacterized protein LOC100142047 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62787 BP_3 26.85 0.39 3635 270016119 EFA12567.1 953 7.4e-100 hypothetical protein TcasGA2_TC004196 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 441 7.1e-42 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF00458//PF09668//PF04110//PF00665 WHEP-TRS domain//Aspartyl protease//Ubiquitin-like autophagy protein Apg12//Integrase core domain GO:0000045//GO:0006508//GO:0006418//GO:0015074 autophagosome assembly//proteolysis//tRNA aminoacylation for protein translation//DNA integration GO:0004190//GO:0005524//GO:0004812 aspartic-type endopeptidase activity//ATP binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.62788 BP_3 1.00 0.36 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6279 BP_3 1.00 0.32 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.62796 BP_3 2.00 0.68 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.628 BP_3 23.00 0.37 3271 270016830 EFA13276.1 1303 1.7e-140 hypothetical protein TcasGA2_TC016027 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 457 8.9e-44 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF09668//PF00098 Aspartyl protease//Zinc knuckle GO:0006508 proteolysis GO:0003676//GO:0004190//GO:0008270 nucleic acid binding//aspartic-type endopeptidase activity//zinc ion binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.62802 BP_3 22.13 0.46 2619 478256392 ENN76582.1 1045 1.1e-110 hypothetical protein YQE_07031, partial [Dendroctonus ponderosae] 462471586 APGK01002379.1 42 5.31903e-10 Dendroctonus ponderosae Seq01002379, whole genome shotgun sequence -- -- -- -- Q17QR8 407 4.5e-38 Putative nuclease HARBI1 OS=Bos taurus GN=HARBI1 PE=2 SV=1 PF01609//PF04827//PF00421//PF04997 Transposase DDE domain//Plant transposon protein//Photosystem II protein//RNA polymerase Rpb1, domain 1 GO:0006351//GO:0006144//GO:0006313//GO:0006206//GO:0009767//GO:0019684 transcription, DNA-templated//purine nucleobase metabolic process//transposition, DNA-mediated//pyrimidine nucleobase metabolic process//photosynthetic electron transport chain//photosynthesis, light reaction GO:0003677//GO:0016168//GO:0003899//GO:0016788//GO:0004803 DNA binding//chlorophyll binding//DNA-directed RNA polymerase activity//hydrolase activity, acting on ester bonds//transposase activity GO:0009521//GO:0016020//GO:0005730 photosystem//membrane//nucleolus -- -- Cluster-8309.62806 BP_3 37.50 0.72 2813 478267817 ENN83104.1 727 9.2e-74 hypothetical protein YQE_00535, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62808 BP_3 324.81 11.14 1697 642923908 XP_008193923.1 505 3.0e-48 PREDICTED: polyglutamine-binding protein 1 [Tribolium castaneum]>gi|270007788|gb|EFA04236.1| hypothetical protein TcasGA2_TC014489 [Tribolium castaneum] -- -- -- -- -- K12865 PQBP1, NPW38 polyglutamine-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12865 Q2HJC9 185 1.6e-12 Polyglutamine-binding protein 1 OS=Bos taurus GN=PQBP1 PE=2 SV=1 PF02724//PF00397 CDC45-like protein//WW domain GO:0006270 DNA replication initiation GO:0005515 protein binding -- -- KOG3427 Polyglutamine tract-binding protein PQBP-1 Cluster-8309.62810 BP_3 12.06 0.39 1794 270001480 EEZ97927.1 499 1.6e-47 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M3K2 167 2.1e-10 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62812 BP_3 3.00 3.61 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62815 BP_3 33.00 4.32 660 570341946 AHE77371.1 354 3.8e-31 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P02516 200 1.1e-14 Heat shock protein 23 OS=Drosophila melanogaster GN=Hsp23 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62819 BP_3 14.00 0.60 1412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62821 BP_3 7.20 0.36 1245 746863315 XP_011062608.1 222 1.5e-15 PREDICTED: zinc finger protein 345-like [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q8IYI8 198 3.7e-14 Zinc finger protein 440 OS=Homo sapiens GN=ZNF440 PE=1 SV=1 PF13912//PF01363//PF06221//PF07776//PF00096//PF13465 C2H2-type zinc finger//FYVE zinc finger//Putative zinc finger motif, C2HC5-type//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.62825 BP_3 23.99 13.17 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62828 BP_3 17.00 2.69 596 642911589 XP_008200663.1 348 1.7e-30 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 259 1.5e-21 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62830 BP_3 4.00 0.40 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.62838 BP_3 7.00 0.44 1056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62839 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62843 BP_3 30.33 0.64 2577 546674262 ERL85681.1 1368 3.9e-148 hypothetical protein D910_03097 [Dendroctonus ponderosae] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q5U2Y6 854 6.5e-90 Tuftelin-interacting protein 11 OS=Rattus norvegicus GN=Tfip11 PE=2 SV=1 PF07842 GC-rich sequence DNA-binding factor-like protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.62847 BP_3 7.05 1.14 590 91083481 XP_971741.1 284 4.5e-23 PREDICTED: probable ATP-dependent RNA helicase spindle-E [Tribolium castaneum]>gi|270011114|gb|EFA07562.1| spindle E [Tribolium castaneum] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 231 2.6e-18 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 -- -- -- -- GO:0097159//GO:1901363//GO:0016787 organic cyclic compound binding//heterocyclic compound binding//hydrolase activity -- -- -- -- Cluster-8309.6285 BP_3 477.40 8.38 3039 189237315 XP_972608.2 2886 0.0e+00 PREDICTED: protocadherin Fat 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9R0M0 378 1.2e-34 Cadherin EGF LAG seven-pass G-type receptor 2 OS=Mus musculus GN=Celsr2 PE=1 SV=2 PF00028//PF12199 Cadherin domain//Extracellular fibrinogen binding protein C terminal GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0001848//GO:0005509 complement binding//calcium ion binding GO:0016020//GO:0005615 membrane//extracellular space KOG3594 FOG: Cadherin repeats Cluster-8309.62856 BP_3 17.48 0.39 2447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62861 BP_3 1.00 0.37 422 780174591 XP_011661157.1 153 5.0e-08 PREDICTED: putative nuclease HARBI1 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62864 BP_3 1.00 1.32 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62865 BP_3 1.00 0.72 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62866 BP_3 89.24 0.75 6036 642911720 XP_971006.2 639 3.1e-63 PREDICTED: polycomb group RING finger protein 3 [Tribolium castaneum] 642911719 XM_965913.3 156 5.23967e-73 PREDICTED: Tribolium castaneum polycomb group RING finger protein 3 (LOC659626), mRNA K11488 PCGF3 polycomb group RING finger protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11488 Q8BTQ0 411 3.5e-38 Polycomb group RING finger protein 3 OS=Mus musculus GN=PcgF3 PE=2 SV=1 PF08125//PF16685//PF13639//PF14634//PF12678//PF06467//PF00097//PF11789 Mannitol dehydrogenase C-terminal domain//zinc RING finger of MSL2//Ring finger domain//zinc-RING finger domain//RING-H2 zinc finger//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit GO:0055114 oxidation-reduction process GO:0050662//GO:0008270//GO:0005515//GO:0016491//GO:0046872//GO:0061630 coenzyme binding//zinc ion binding//protein binding//oxidoreductase activity//metal ion binding//ubiquitin protein ligase activity -- -- KOG2660 Locus-specific chromosome binding proteins Cluster-8309.62868 BP_3 17.58 1.60 821 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6287 BP_3 4.00 0.52 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.62872 BP_3 2.00 0.65 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62881 BP_3 43.33 0.66 3478 478257833 ENN77976.1 706 3.1e-71 hypothetical protein YQE_05652, partial [Dendroctonus ponderosae] -- -- -- -- -- K18665 NUDT8 nudix motif 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18665 Q8WV74 264 2.3e-21 Nucleoside diphosphate-linked moiety X motif 8, mitochondrial OS=Homo sapiens GN=NUDT8 PE=2 SV=2 PF00293//PF07648//PF00050 NUDIX domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0016787//GO:0005515 hydrolase activity//protein binding -- -- KOG3069 Peroxisomal NUDIX hydrolase Cluster-8309.62885 BP_3 6.00 1.23 526 546679823 ERL90215.1 271 1.3e-21 hypothetical protein D910_07568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5R7K0 160 3.9e-10 Inactive hydroxysteroid dehydrogenase-like protein 1 OS=Pongo abelii GN=HSDL1 PE=2 SV=1 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.62888 BP_3 16.08 0.47 1938 662195961 XP_008470989.1 929 2.4e-97 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62889 BP_3 62.59 0.72 4463 662195961 XP_008470989.1 882 1.5e-91 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.62891 BP_3 52.00 1.55 1904 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62892 BP_3 8.00 0.33 1446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62895 BP_3 36.70 0.43 4411 662195961 XP_008470989.1 530 1.0e-50 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00589 BED zinc finger//Phage integrase family GO:0006310//GO:0015074 DNA recombination//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.62897 BP_3 45.63 0.54 4395 662195961 XP_008470989.1 914 3.0e-95 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.62899 BP_3 11.00 1.73 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62900 BP_3 34.13 2.51 946 91093355 XP_969078.1 531 1.6e-51 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62903 BP_3 10.12 1.22 691 91092366 XP_971881.1 151 1.4e-07 PREDICTED: DNA polymerase epsilon subunit 4 [Tribolium castaneum]>gi|270015716|gb|EFA12164.1| hypothetical protein TcasGA2_TC002314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0043565//GO:0003677//GO:0046982 sequence-specific DNA binding//DNA binding//protein heterodimerization activity GO:0005622 intracellular -- -- Cluster-8309.62907 BP_3 90.52 2.21 2263 642935762 XP_008198164.1 1462 4.4e-159 PREDICTED: uncharacterized protein C2orf42 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SYX3 691 4.5e-71 Uncharacterized protein C2orf42 homolog OS=Bos taurus PE=2 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.6291 BP_3 113.00 3.24 1972 189236231 XP_972574.2 1194 4.5e-128 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270005539|gb|EFA01987.1| hypothetical protein TcasGA2_TC007608 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 757 8.8e-79 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF01266//PF05834//PF07992//PF00732//PF05199//PF02558 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//GMC oxidoreductase//Ketopantoate reductase PanE/ApbA GO:0015940//GO:0016117//GO:0055114 pantothenate biosynthetic process//carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0016614//GO:0016491//GO:0008677//GO:0050660 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity//2-dehydropantoate 2-reductase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.62913 BP_3 20.63 0.50 2278 270009850 EFA06298.1 680 2.1e-68 hypothetical protein TcasGA2_TC009165 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N302 320 4.8e-28 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF07851//PF00498 TMPIT-like protein//FHA domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.62917 BP_3 10.00 0.50 1261 641666824 XP_008183865.1 568 1.1e-55 PREDICTED: uncharacterized protein LOC103309651 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q95SX7 386 5.9e-36 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF01691 Adenovirus E1B 19K protein / small t-antigen GO:0043066 negative regulation of apoptotic process GO:0005521 lamin binding -- -- -- -- Cluster-8309.62924 BP_3 150.46 5.10 1714 478259252 ENN79154.1 446 2.1e-41 hypothetical protein YQE_04340, partial [Dendroctonus ponderosae]>gi|546678412|gb|ERL89035.1| hypothetical protein D910_06413 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86BJ3 165 3.4e-10 Heparan sulfate 2-O-sulfotransferase pipe OS=Drosophila melanogaster GN=pip PE=1 SV=1 PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.62927 BP_3 51.07 1.67 1766 270015507 EFA11955.1 512 4.9e-49 hypothetical protein TcasGA2_TC008556 [Tribolium castaneum] -- -- -- -- -- K03504 POLD3 DNA polymerase delta subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03504 Q9EQ28 188 7.5e-13 DNA polymerase delta subunit 3 OS=Mus musculus GN=Pold3 PE=1 SV=2 PF09507//PF08689//PF00538 DNA polymerase subunit Cdc27//Mediator complex subunit Med5//linker histone H1 and H5 family GO:0006334//GO:0006260//GO:0006357 nucleosome assembly//DNA replication//regulation of transcription from RNA polymerase II promoter GO:0003677//GO:0001104 DNA binding//RNA polymerase II transcription cofactor activity GO:0000786//GO:0005634//GO:0016592 nucleosome//nucleus//mediator complex -- -- Cluster-8309.62928 BP_3 25.86 1.94 934 642939840 XP_008193774.1 226 3.8e-16 PREDICTED: DNA polymerase delta subunit 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06390 Neuroendocrine-specific golgi protein P55 (NESP55) GO:0071107 response to parathyroid hormone -- -- -- -- -- -- Cluster-8309.62938 BP_3 42.76 0.45 4906 91085743 XP_973670.1 2550 6.5e-285 PREDICTED: Fanconi anemia group M protein homolog [Tribolium castaneum] 884966605 XM_013137615.1 65 1.64173e-22 PREDICTED: Esox lucius Fanconi anemia, complementation group M (fancm), mRNA K10896 FANCM fanconi anemia group M protein http://www.genome.jp/dbget-bin/www_bget?ko:K10896 Q8IYD8 1231 2.4e-133 Fanconi anemia group M protein OS=Homo sapiens GN=FANCM PE=1 SV=2 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding -- -- KOG0354 DEAD-box like helicase Cluster-8309.62944 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62946 BP_3 68.02 4.42 1034 642929027 XP_973541.3 728 2.6e-74 PREDICTED: probable maleylacetoacetate isomerase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01800 maiA, GSTZ1 maleylacetoacetate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01800 Q9VHD2 686 7.8e-71 Probable maleylacetoacetate isomerase 2 OS=Drosophila melanogaster GN=GstZ2 PE=1 SV=1 PF13417//PF00462//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0005515//GO:0009055//GO:0015035 protein binding//electron carrier activity//protein disulfide oxidoreductase activity -- -- KOG0868 Glutathione S-transferase Cluster-8309.6295 BP_3 16.00 4.44 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62952 BP_3 5.36 0.32 1106 642935095 XP_008197883.1 165 5.3e-09 PREDICTED: uncharacterized protein LOC103314233 [Tribolium castaneum]>gi|270013398|gb|EFA09846.1| hypothetical protein TcasGA2_TC011994 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09252 Allergen Fel d I-B chain -- -- -- -- GO:0005615 extracellular space -- -- Cluster-8309.62958 BP_3 166.50 6.17 1593 270000766 EEZ97213.1 1295 7.1e-140 hypothetical protein TcasGA2_TC011005 [Tribolium castaneum] -- -- -- -- -- K18403 MSL3 male-specific lethal 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18403 Q5R6Y9 507 6.9e-50 Male-specific lethal 3 homolog OS=Pongo abelii GN=MSL3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.62962 BP_3 12.46 0.31 2251 642931828 XP_971231.2 1643 4.5e-180 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q8BH70 568 8.2e-57 F-box/LRR-repeat protein 4 OS=Mus musculus GN=Fbxl4 PE=2 SV=1 PF13516//PF12937//PF00560//PF00646//PF15966 Leucine Rich repeat//F-box-like//Leucine Rich Repeat//F-box domain//F-box -- -- GO:0005515 protein binding -- -- KOG4341 F-box protein containing LRR Cluster-8309.62966 BP_3 6.00 0.36 1087 270007545 EFA03993.1 167 3.0e-09 hypothetical protein TcasGA2_TC014142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG1919 RNA pseudouridylate synthases Cluster-8309.62972 BP_3 5.00 0.37 948 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62983 BP_3 109.00 0.87 6331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62986 BP_3 154.26 1.53 5136 478259252 ENN79154.1 278 1.9e-21 hypothetical protein YQE_04340, partial [Dendroctonus ponderosae]>gi|546678412|gb|ERL89035.1| hypothetical protein D910_06413 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.62988 BP_3 7.50 0.36 1304 91087801 XP_967436.1 1136 1.6e-121 PREDICTED: 39S ribosomal protein L39, mitochondrial [Tribolium castaneum]>gi|270010754|gb|EFA07202.1| hypothetical protein TcasGA2_TC010209 [Tribolium castaneum] -- -- -- -- -- K17420 MRPL39 large subunit ribosomal protein L39 http://www.genome.jp/dbget-bin/www_bget?ko:K17420 Q9VUJ0 716 3.3e-74 39S ribosomal protein L39, mitochondrial OS=Drosophila melanogaster GN=mRpL39 PE=1 SV=2 -- -- -- -- GO:0000166 nucleotide binding -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.62991 BP_3 13.00 0.43 1734 49119653 AAH73141.1 1174 8.3e-126 YWHAZ protein, partial [Homo sapiens] 767953585 XM_005251062.2 1629 0 PREDICTED: Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (YWHAZ), transcript variant X2, mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 P63103 1170 9.9e-127 14-3-3 protein zeta/delta OS=Bos taurus GN=YWHAZ PE=1 SV=1 PF02154//PF15499//PF11808 Flagellar motor switch protein FliM//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Domain of unknown function (DUF3329) GO:0016310//GO:0071973 phosphorylation//bacterial-type flagellum-dependent cell motility GO:0003774//GO:0004673//GO:0032183//GO:0070140 motor activity//protein histidine kinase activity//SUMO binding//SUMO-specific isopeptidase activity GO:0009425//GO:0009365 bacterial-type flagellum basal body//protein histidine kinase complex -- -- Cluster-8309.62992 BP_3 29.33 0.99 1724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62997 BP_3 1.00 3.59 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62999 BP_3 118.80 1.97 3201 642910641 XP_008200040.1 2512 1.1e-280 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 545 0 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q7Z6J6 787 4.7e-82 FERM domain-containing protein 5 OS=Homo sapiens GN=FRMD5 PE=1 SV=1 PF15168 Triple QxxK/R motif-containing protein family -- -- GO:0008092 cytoskeletal protein binding GO:0005789//GO:0005856//GO:0019898//GO:0005737 endoplasmic reticulum membrane//cytoskeleton//extrinsic component of membrane//cytoplasm KOG3530 FERM domain protein EHM2 Cluster-8309.63 BP_3 4.00 0.53 655 410446425 AFV69126.1 537 2.3e-52 mitochondrial cytochrome c oxidase subunit Vb [Litopenaeus vannamei] -- -- -- -- -- K02265 COX5B cytochrome c oxidase subunit 5b http://www.genome.jp/dbget-bin/www_bget?ko:K02265 P00428 208 1.3e-15 Cytochrome c oxidase subunit 5B, mitochondrial OS=Bos taurus GN=COX5B PE=1 SV=2 PF01215 Cytochrome c oxidase subunit Vb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005740 respiratory chain complex IV//mitochondrial envelope KOG3352 Cytochrome c oxidase, subunit Vb/COX4 Cluster-8309.630 BP_3 5.70 0.51 826 91083989 XP_975221.1 306 1.8e-25 PREDICTED: CKLF-like MARVEL transmembrane domain-containing protein 8 [Tribolium castaneum]>gi|270007988|gb|EFA04436.1| hypothetical protein TcasGA2_TC014737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.63002 BP_3 1.00 0.40 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63003 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63007 BP_3 78.50 1.50 2820 642927240 XP_008195192.1 2388 2.3e-266 PREDICTED: DNA helicase MCM8 [Tribolium castaneum]>gi|270010001|gb|EFA06449.1| hypothetical protein TcasGA2_TC009331 [Tribolium castaneum] -- -- -- -- -- K10737 MCM8 DNA helicase MCM8 http://www.genome.jp/dbget-bin/www_bget?ko:K10737 I0IUP3 1678 2.0e-185 DNA helicase MCM8 OS=Gallus gallus GN=MCM8 PE=1 SV=1 PF00158//PF05496//PF07728//PF07726//PF01580//PF00004//PF00493 Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//FtsK/SpoIIIE family//ATPase family associated with various cellular activities (AAA)//MCM2/3/5 family GO:0006281//GO:0006260//GO:0006310//GO:0006355 DNA repair//DNA replication//DNA recombination//regulation of transcription, DNA-templated GO:0008134//GO:0003677//GO:0005524//GO:0009378//GO:0016887//GO:0000166 transcription factor binding//DNA binding//ATP binding//four-way junction helicase activity//ATPase activity//nucleotide binding GO:0005667//GO:0009379//GO:0005657 transcription factor complex//Holliday junction helicase complex//replication fork KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.63008 BP_3 19.57 0.46 2340 478255416 ENN75638.1 1193 7.0e-128 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 902 1.6e-95 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.63012 BP_3 15.55 0.67 1406 662202607 XP_008474607.1 497 2.1e-47 PREDICTED: piggyBac transposable element-derived protein 2-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q8N328 463 7.7e-45 PiggyBac transposable element-derived protein 3 OS=Homo sapiens GN=PGBD3 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63015 BP_3 2.00 0.70 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63016 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63018 BP_3 7.98 0.31 1545 642915148 XP_008190494.1 253 4.6e-19 PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915150|ref|XP_008190495.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915152|ref|XP_008190496.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915154|ref|XP_008190497.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63023 BP_3 19.28 0.51 2103 642937579 XP_008199106.1 517 1.5e-49 PREDICTED: protein bric-a-brac 1-like isoform X1 [Tribolium castaneum]>gi|270001234|gb|EEZ97681.1| hypothetical protein TcasGA2_TC016226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63024 BP_3 1.00 6.33 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63025 BP_3 42.81 2.63 1075 478251534 ENN71996.1 351 1.4e-30 hypothetical protein YQE_11287, partial [Dendroctonus ponderosae]>gi|546681198|gb|ERL91333.1| hypothetical protein D910_08665 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P10776 162 4.7e-10 Neuroparsin-A OS=Locusta migratoria PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63026 BP_3 28.00 2.45 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63027 BP_3 8.00 0.64 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07966 A1 Propeptide GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.6303 BP_3 89.00 2.29 2165 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63030 BP_3 39.01 0.39 5079 752866884 XP_011250445.1 2335 5.8e-260 PREDICTED: SCAN domain-containing protein 3-like [Camponotus floridanus] 751233256 XM_011171998.1 377 0 PREDICTED: Solenopsis invicta zinc finger BED domain-containing protein 5-like (LOC105203223), mRNA -- -- -- -- Q6R2W3 816 3.3e-85 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 PF06305//PF02892//PF05699 Protein of unknown function (DUF1049)//BED zinc finger//hAT family C-terminal dimerisation region -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.63031 BP_3 9.44 0.94 775 478250954 ENN71438.1 351 1.0e-30 hypothetical protein YQE_11857, partial [Dendroctonus ponderosae]>gi|546682677|gb|ERL92589.1| hypothetical protein D910_09902 [Dendroctonus ponderosae] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 P27766 216 1.9e-16 Dynein, 70 kDa intermediate chain, flagellar outer arm OS=Chlamydomonas reinhardtii GN=ODA6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63036 BP_3 2.00 0.38 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63037 BP_3 2.00 0.75 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6304 BP_3 191.96 1.75 5591 91086865 XP_969198.1 2823 0.0e+00 PREDICTED: probable serine/threonine-protein kinase nek3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 167 6.5e-10 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.63045 BP_3 47.56 1.29 2070 830120960 XP_012585728.1 299 2.9e-24 PREDICTED: zinc finger protein 41 [Condylura cristata] -- -- -- -- -- -- -- -- -- Q06730 291 1.0e-24 Zinc finger protein 33A OS=Homo sapiens GN=ZNF33A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63048 BP_3 1.00 0.80 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63052 BP_3 18.65 1.90 766 641681966 XP_008189661.1 241 5.6e-18 PREDICTED: general transcription factor II-I repeat domain-containing protein 2-like, partial [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- A4IFA3 190 1.9e-13 General transcription factor II-I repeat domain-containing protein 2 OS=Bos taurus GN=GTF2IRD2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63053 BP_3 29.09 0.50 3084 642935223 XP_008199698.1 2123 1.3e-235 PREDICTED: uncharacterized protein LOC103314735 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58CV6 236 3.5e-18 Kelch domain-containing protein 3 OS=Bos taurus GN=KLHDC3 PE=2 SV=2 PF07646//PF01239//PF01344 Kelch motif//Protein prenyltransferase alpha subunit repeat//Kelch motif GO:0018342 protein prenylation GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity -- -- -- -- Cluster-8309.63063 BP_3 28.67 1.39 1287 270015435 EFA11883.1 702 3.3e-71 hypothetical protein TcasGA2_TC004298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63064 BP_3 9.78 0.35 1630 270015435 EFA11883.1 456 1.4e-42 hypothetical protein TcasGA2_TC004298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63071 BP_3 112.63 5.57 1267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63080 BP_3 160.90 2.53 3357 478260698 ENN80386.1 1173 2.1e-125 hypothetical protein YQE_03188, partial [Dendroctonus ponderosae] -- -- -- -- -- K10398 KIF11, EG5 kinesin family member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10398 P46863 1043 1.0e-111 Bipolar kinesin KRP-130 OS=Drosophila melanogaster GN=Klp61F PE=1 SV=2 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0243 Kinesin-like protein Cluster-8309.63081 BP_3 14.44 0.39 2076 642919569 XP_008191926.1 268 1.1e-20 PREDICTED: protein angel homolog 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 B2RYM0 175 2.8e-11 Protein angel homolog 1 OS=Rattus norvegicus GN=Angel1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2338 Transcriptional effector CCR4-related protein Cluster-8309.63089 BP_3 1.00 0.84 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63092 BP_3 260.09 2.57 5171 478259252 ENN79154.1 278 2.0e-21 hypothetical protein YQE_04340, partial [Dendroctonus ponderosae]>gi|546678412|gb|ERL89035.1| hypothetical protein D910_06413 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.63096 BP_3 2.00 0.40 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.631 BP_3 11.00 0.33 1917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63101 BP_3 25.04 4.07 588 189234531 XP_967948.2 203 1.1e-13 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 179 2.7e-12 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF03522 Solute carrier family 12 GO:0055085//GO:0006821//GO:0006810//GO:0006812//GO:0006811 transmembrane transport//chloride transport//transport//cation transport//ion transport GO:0005215//GO:0015377 transporter activity//cation:chloride symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2083 Na+/K+ symporter Cluster-8309.63102 BP_3 23.62 2.86 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63108 BP_3 38.17 1.55 1475 641660547 XP_008181531.1 557 2.5e-54 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity -- -- -- -- Cluster-8309.63109 BP_3 42.68 1.93 1359 641651338 XP_003241056.2 738 2.3e-75 PREDICTED: uncharacterized protein LOC100574409 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63116 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63117 BP_3 146.83 1.99 3845 662195961 XP_008470989.1 905 2.9e-94 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63121 BP_3 43.58 0.62 3653 642926332 XP_968832.2 1809 4.1e-199 PREDICTED: RING finger protein 207 isoform X2 [Tribolium castaneum] 642926333 XM_008196659.1 246 2.94291e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q3V3A7 600 2.6e-60 RING finger protein 207 OS=Mus musculus GN=Rnf207 PE=2 SV=2 PF10392//PF00097//PF00643//PF14634//PF05791//PF16685//PF13639//PF04673//PF08702//PF11802//PF04513//PF04728 Golgi transport complex subunit 5//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger//zinc-RING finger domain//Bacillus haemolytic enterotoxin (HBL)//zinc RING finger of MSL2//Ring finger domain//Polyketide synthesis cyclase//Fibrinogen alpha/beta chain family//Centromere-associated protein K//Baculovirus polyhedron envelope protein, PEP, C terminus//Lipoprotein leucine-zipper GO:0006891//GO:0030168//GO:0009405//GO:0007165//GO:0030639//GO:0051258 intra-Golgi vesicle-mediated transport//platelet activation//pathogenesis//signal transduction//polyketide biosynthetic process//protein polymerization GO:0061630//GO:0005515//GO:0030674//GO:0046872//GO:0005198//GO:0008270//GO:0005102 ubiquitin protein ligase activity//protein binding//protein binding, bridging//metal ion binding//structural molecule activity//zinc ion binding//receptor binding GO:0005634//GO:0019867//GO:0019031//GO:0016020//GO:0017119//GO:0019028//GO:0005622//GO:0005577 nucleus//outer membrane//viral envelope//membrane//Golgi transport complex//viral capsid//intracellular//fibrinogen complex -- -- Cluster-8309.63125 BP_3 35.82 0.42 4404 642915022 XP_008190487.1 3566 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] 642915021 XM_008192265.1 765 0 PREDICTED: Tribolium castaneum cubilin (LOC662433), mRNA -- -- -- -- Q9JLB4 403 2.2e-37 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF05393//PF04162//PF02480//PF00057//PF15681 Human adenovirus early E3A glycoprotein//Gyrovirus capsid protein (VP1)//Alphaherpesvirus glycoprotein E//Low-density lipoprotein receptor domain class A//Lymphocyte activation family X GO:0006955//GO:0051249 immune response//regulation of lymphocyte activation GO:0005515 protein binding GO:0016020//GO:0019028//GO:0016021 membrane//viral capsid//integral component of membrane KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.63134 BP_3 113.61 5.19 1346 157133236 XP_001656193.1 341 2.5e-29 AAEL012688-PA [Aedes aegypti]>gi|108870898|gb|EAT35123.1| AAEL012688-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63136 BP_3 4.00 0.39 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63143 BP_3 3.00 0.44 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63150 BP_3 24.46 0.34 3739 642920523 XP_008192386.1 1457 2.7e-158 PREDICTED: cytoplasmic dynein 2 heavy chain 1 [Tribolium castaneum] -- -- -- -- -- K10414 DYNC2H, DNCH2 dynein heavy chain 2, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10414 Q8NCM8 783 1.6e-81 Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens GN=DYNC2H1 PE=1 SV=4 PF03028//PF01834 Dynein heavy chain and region D6 of dynein motor//XRCC1 N terminal domain GO:0007017//GO:0007018//GO:0000012//GO:0006281 microtubule-based process//microtubule-based movement//single strand break repair//DNA repair GO:0003684//GO:0003777 damaged DNA binding//microtubule motor activity GO:0005634//GO:0030286//GO:0005874 nucleus//dynein complex//microtubule KOG3595 Dyneins, heavy chain Cluster-8309.63152 BP_3 9.56 0.63 1020 478262632 ENN81196.1 628 1.0e-62 hypothetical protein YQE_02386, partial [Dendroctonus ponderosae] -- -- -- -- -- K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O43150 467 1.9e-45 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens GN=ASAP2 PE=1 SV=3 PF08397//PF03114 IRSp53/MIM homology domain//BAR domain GO:0007009 plasma membrane organization GO:0005515 protein binding GO:0005737 cytoplasm -- -- Cluster-8309.63155 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63157 BP_3 5.88 0.56 794 546684576 ERL94201.1 178 1.2e-10 hypothetical protein D910_11482 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03083 Sugar efflux transporter for intercellular exchange -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.63158 BP_3 151.18 1.29 5955 642914333 XP_008201635.1 1490 6.5e-162 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum] 752869466 XM_011253546.1 255 4.78194e-128 PREDICTED: Camponotus floridanus glutamate receptor ionotropic, kainate 2 (LOC105248646), transcript variant X2, mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P39087 911 3.7e-96 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF00060 Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.63163 BP_3 1.00 0.34 431 170035381 XP_001845548.1 167 1.2e-09 chloride channel protein 2 [Culex quinquefasciatus]>gi|167877364|gb|EDS40747.1| chloride channel protein 2 [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- Q9VGH7 134 3.3e-07 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63164 BP_3 18.18 0.32 3066 270008907 EFA05355.1 1781 6.0e-196 hypothetical protein TcasGA2_TC015520 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1698 1.0e-187 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654//PF09514 Voltage gated chloride channel//SSXRD motif GO:0006821//GO:0006355//GO:0055085 chloride transport//regulation of transcription, DNA-templated//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0005634//GO:0016020 nucleus//membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.63165 BP_3 33.82 0.62 2914 270008907 EFA05355.1 1781 5.7e-196 hypothetical protein TcasGA2_TC015520 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1698 9.9e-188 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF09514//PF00654 SSXRD motif//Voltage gated chloride channel GO:0055085//GO:0006355//GO:0006821 transmembrane transport//regulation of transcription, DNA-templated//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020//GO:0005634 membrane//nucleus KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.63173 BP_3 4.00 0.42 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63182 BP_3 29.35 0.97 1745 91077324 XP_974759.1 577 1.4e-56 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270001669|gb|EEZ98116.1| hypothetical protein TcasGA2_TC000534 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 P17817 350 1.2e-31 Pyrroline-5-carboxylate reductase OS=Glycine max PE=2 SV=1 PF00479//PF01210//PF03446 Glucose-6-phosphate dehydrogenase, NAD binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006098//GO:0006525//GO:0046168//GO:0006749//GO:0006006//GO:0006561//GO:0019521//GO:0055114 pentose-phosphate shunt//arginine metabolic process//glycerol-3-phosphate catabolic process//glutathione metabolic process//glucose metabolic process//proline biosynthetic process//D-gluconate metabolic process//oxidation-reduction process GO:0004735//GO:0050661//GO:0016616//GO:0051287//GO:0000166//GO:0004616//GO:0004345 pyrroline-5-carboxylate reductase activity//NADP binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity//glucose-6-phosphate dehydrogenase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.6319 BP_3 23.94 1.13 1317 270015016 EFA11464.1 874 3.9e-91 hypothetical protein TcasGA2_TC014173 [Tribolium castaneum] -- -- -- -- -- K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q9VD28 750 3.8e-78 Bifunctional arginine demethylase and lysyl-hydroxylase PSR OS=Drosophila melanogaster GN=PSR PE=2 SV=1 PF11734 TilS substrate C-terminal domain GO:0008033 tRNA processing GO:0016879//GO:0000166//GO:0005524 ligase activity, forming carbon-nitrogen bonds//nucleotide binding//ATP binding GO:0005737 cytoplasm KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain Cluster-8309.63192 BP_3 160.46 3.43 2546 642926658 XP_008194957.1 259 1.5e-19 PREDICTED: uncharacterized protein LOC103313445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF02899//PF07544//PF09429 THAP domain//Phage integrase, N-terminal SAM-like domain//RNA polymerase II transcription mediator complex subunit 9//WW domain binding protein 11 GO:0006396//GO:0015074//GO:0006357 RNA processing//DNA integration//regulation of transcription from RNA polymerase II promoter GO:0003677//GO:0001104//GO:0003676 DNA binding//RNA polymerase II transcription cofactor activity//nucleic acid binding GO:0016592 mediator complex -- -- Cluster-8309.63193 BP_3 83.66 1.90 2415 642926658 XP_008194957.1 259 1.5e-19 PREDICTED: uncharacterized protein LOC103313445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZMV9 184 3.0e-12 Kinesin-like protein KIF6 OS=Homo sapiens GN=KIF6 PE=1 SV=3 PF07544 RNA polymerase II transcription mediator complex subunit 9 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.63194 BP_3 36.79 0.70 2837 642926658 XP_008194957.1 259 1.7e-19 PREDICTED: uncharacterized protein LOC103313445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09429//PF07544//PF02899//PF05485 WW domain binding protein 11//RNA polymerase II transcription mediator complex subunit 9//Phage integrase, N-terminal SAM-like domain//THAP domain GO:0006357//GO:0015074//GO:0006396 regulation of transcription from RNA polymerase II promoter//DNA integration//RNA processing GO:0003677//GO:0001104//GO:0003676 DNA binding//RNA polymerase II transcription cofactor activity//nucleic acid binding GO:0016592 mediator complex -- -- Cluster-8309.63198 BP_3 104.74 1.38 3959 746851045 XP_011056028.1 1661 6.4e-182 PREDICTED: uncharacterized protein LOC105147016 isoform X4 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q9STP8 136 1.8e-06 Acyl-CoA-binding domain-containing protein 2 OS=Arabidopsis thaliana GN=ACBP2 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.632 BP_3 48.41 0.33 7424 642923970 XP_008193945.1 2261 3.2e-251 PREDICTED: hydrocephalus-inducing protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W93 1208 1.7e-130 Hydrocephalus-inducing protein OS=Mus musculus GN=Hydin PE=2 SV=2 PF04194//PF01080 Programmed cell death protein 2, C-terminal putative domain//Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm -- -- Cluster-8309.63204 BP_3 75.48 1.06 3720 642931800 XP_008196735.1 1772 8.1e-195 PREDICTED: probable tRNA (guanine(26)-N(2))-dimethyltransferase [Tribolium castaneum] 805826840 XM_012297893.1 36 1.64098e-06 PREDICTED: Megachile rotundata probable tRNA (guanine(26)-N(2))-dimethyltransferase (LOC105664233), mRNA K00555 TRMT1, trm1 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00555 Q9VK89 1470 3.5e-161 Probable tRNA (guanine(26)-N(2))-dimethyltransferase OS=Drosophila melanogaster GN=CG6388 PE=2 SV=1 PF05175//PF03602//PF02005//PF05958 Methyltransferase small domain//Conserved hypothetical protein 95//N2,N2-dimethylguanosine tRNA methyltransferase//tRNA (Uracil-5-)-methyltransferase GO:0009451//GO:0006396//GO:0008033//GO:0031167 RNA modification//RNA processing//tRNA processing//rRNA methylation GO:0004809//GO:0008168//GO:0003723//GO:0008173 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//RNA binding//RNA methyltransferase activity -- -- KOG1253 tRNA methyltransferase Cluster-8309.63209 BP_3 18.78 0.93 1261 546684866 ERL94448.1 1360 1.6e-147 hypothetical protein D910_11725 [Dendroctonus ponderosae] -- -- -- -- -- K16462 CEP164 centrosomal protein CEP164 http://www.genome.jp/dbget-bin/www_bget?ko:K16462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63210 BP_3 62.05 1.68 2074 478250911 ENN71396.1 902 3.4e-94 hypothetical protein YQE_11900, partial [Dendroctonus ponderosae] -- -- -- -- -- K16462 CEP164 centrosomal protein CEP164 http://www.genome.jp/dbget-bin/www_bget?ko:K16462 -- -- -- -- PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63211 BP_3 106.22 0.84 6356 642919021 XP_008191699.1 1761 2.6e-193 PREDICTED: centrosomal protein of 164 kDa isoform X1 [Tribolium castaneum]>gi|270005603|gb|EFA02051.1| hypothetical protein TcasGA2_TC007679 [Tribolium castaneum] -- -- -- -- -- K16462 CEP164 centrosomal protein CEP164 http://www.genome.jp/dbget-bin/www_bget?ko:K16462 Q5DU05 178 3.9e-11 Centrosomal protein of 164 kDa OS=Mus musculus GN=Cep164 PE=2 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63212 BP_3 67.23 0.52 6545 642919021 XP_008191699.1 1339 2.3e-144 PREDICTED: centrosomal protein of 164 kDa isoform X1 [Tribolium castaneum]>gi|270005603|gb|EFA02051.1| hypothetical protein TcasGA2_TC007679 [Tribolium castaneum] -- -- -- -- -- K16462 CEP164 centrosomal protein CEP164 http://www.genome.jp/dbget-bin/www_bget?ko:K16462 Q5DU05 178 4.0e-11 Centrosomal protein of 164 kDa OS=Mus musculus GN=Cep164 PE=2 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63213 BP_3 52.18 0.42 6277 642919021 XP_008191699.1 1761 2.6e-193 PREDICTED: centrosomal protein of 164 kDa isoform X1 [Tribolium castaneum]>gi|270005603|gb|EFA02051.1| hypothetical protein TcasGA2_TC007679 [Tribolium castaneum] -- -- -- -- -- K16462 CEP164 centrosomal protein CEP164 http://www.genome.jp/dbget-bin/www_bget?ko:K16462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63216 BP_3 12.18 1.11 822 546674391 ERL85778.1 215 6.2e-15 hypothetical protein D910_03193 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q505G8 162 3.6e-10 Zinc finger protein 827 OS=Mus musculus GN=Znf827 PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.6322 BP_3 53.55 0.73 3837 815782437 XP_012214515.1 520 1.3e-49 PREDICTED: uncharacterized protein LOC105667345 isoform X2 [Linepithema humile] -- -- -- -- -- -- -- -- -- Q96QF7 232 1.3e-17 Acidic repeat-containing protein OS=Homo sapiens GN=ACRC PE=2 SV=1 PF02290//PF02599//PF02305 Signal recognition particle 14kD protein//Global regulator protein family//Capsid protein (F protein) GO:0006614//GO:0006402//GO:0006109 SRP-dependent cotranslational protein targeting to membrane//mRNA catabolic process//regulation of carbohydrate metabolic process GO:0008312//GO:0030942//GO:0003723//GO:0005198 7S RNA binding//endoplasmic reticulum signal peptide binding//RNA binding//structural molecule activity GO:0019028//GO:0005786 viral capsid//signal recognition particle, endoplasmic reticulum targeting KOG3854 SPRT-like metalloprotease Cluster-8309.63221 BP_3 5.00 0.35 979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395//PF03839//PF06151 7tm Chemosensory receptor//Translocation protein Sec62//Trehalose receptor GO:0050909//GO:0050912//GO:0015031//GO:0007187//GO:0007607 sensory perception of taste//detection of chemical stimulus involved in sensory perception of taste//protein transport//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//obsolete taste perception GO:0008565//GO:0008527 protein transporter activity//taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.63227 BP_3 6.00 1.24 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63232 BP_3 17.17 1.18 995 546684931 ERL94513.1 484 4.9e-46 hypothetical protein D910_11790 [Dendroctonus ponderosae] -- -- -- -- -- K17429 MRPL48 large subunit ribosomal protein L48 http://www.genome.jp/dbget-bin/www_bget?ko:K17429 Q2YDI5 203 7.7e-15 39S ribosomal protein L48, mitochondrial OS=Bos taurus GN=MRPL48 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4060 Uncharacterized conserved protein Cluster-8309.63233 BP_3 77.04 0.45 8459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63237 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63241 BP_3 1.00 0.31 445 546676898 ERL87822.1 525 3.8e-51 hypothetical protein D910_05211 [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q28HF8 306 3.9e-27 Sodium/bile acid cotransporter 7 OS=Xenopus tropicalis GN=slc10a7 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63244 BP_3 8.00 1.87 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63248 BP_3 4.79 0.39 889 478254838 ENN75074.1 628 8.7e-63 hypothetical protein YQE_08387, partial [Dendroctonus ponderosae] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9HCN4 477 1.2e-46 GPN-loop GTPase 1 OS=Homo sapiens GN=GPN1 PE=1 SV=1 PF06512//PF02378//PF00025 Sodium ion transport-associated//Phosphotransferase system, EIIC//ADP-ribosylation factor family GO:0008643//GO:0006814//GO:0009401 carbohydrate transport//sodium ion transport//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005525//GO:0008982//GO:0005248 GTP binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//voltage-gated sodium channel activity GO:0009357//GO:0016020//GO:0001518 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane//voltage-gated sodium channel complex KOG1532 GTPase XAB1, interacts with DNA repair protein XPA Cluster-8309.63250 BP_3 23.17 0.70 1878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63255 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63265 BP_3 20.34 0.42 2621 668462962 KFB50405.1 685 6.3e-69 AGAP005747-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- Q96NJ6 204 1.5e-14 Zinc finger protein 3 homolog OS=Homo sapiens GN=ZFP3 PE=2 SV=1 PF00651//PF13912//PF00096//PF13465 BTB/POZ domain//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.63276 BP_3 25.00 0.48 2777 642929346 XP_008195796.1 706 2.5e-71 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 [Tribolium castaneum]>gi|270009635|gb|EFA06083.1| hypothetical protein TcasGA2_TC008920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q552X2 168 2.5e-10 Putative mediator of RNA polymerase II transcription subunit 26 OS=Dictyostelium discoideum GN=med26 PE=3 SV=2 PF08651 DASH complex subunit Duo1 GO:0007067 mitotic nuclear division -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.63279 BP_3 2.00 0.50 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63280 BP_3 27.08 0.71 2124 642927623 XP_008195338.1 237 4.6e-17 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08551 Eukaryotic integral membrane protein (DUF1751) GO:0006890 retrograde vesicle-mediated transport, Golgi to ER -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.63288 BP_3 300.65 3.84 4068 546676034 ERL87120.1 642 9.5e-64 hypothetical protein D910_04520, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RE88 381 7.2e-35 WD repeat-containing protein 66 OS=Pongo abelii GN=WDR66 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63291 BP_3 1.00 0.33 437 478251169 ENN71645.1 244 1.4e-18 hypothetical protein YQE_11743, partial [Dendroctonus ponderosae]>gi|546685828|gb|ERL95271.1| hypothetical protein D910_12537 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63296 BP_3 12.98 1.81 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63297 BP_3 5.00 0.51 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63301 BP_3 106.59 28.93 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63305 BP_3 75.00 0.99 3935 -- -- -- -- -- 462283145 APGK01057037.1 45 1.72451e-11 Dendroctonus ponderosae Seq01057047, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63306 BP_3 6.00 0.49 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63307 BP_3 64.86 0.83 4039 642931926 XP_008196783.1 1049 6.0e-111 PREDICTED: uncharacterized protein LOC103313947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4VA61 130 9.1e-06 Down syndrome cell adhesion molecule-like protein 1 homolog OS=Mus musculus GN=Dscaml1 PE=1 SV=2 PF13895//PF02892 Immunoglobulin domain//BED zinc finger -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.6331 BP_3 31.63 0.61 2787 751223799 XP_011165208.1 760 1.4e-77 PREDICTED: uncharacterized protein LOC105199705 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827//PF03979//PF08715 Transposase DDE domain//Plant transposon protein//Sigma-70 factor, region 1.1//Papain like viral protease GO:0006313//GO:0006508//GO:0006355 transposition, DNA-mediated//proteolysis//regulation of transcription, DNA-templated GO:0008242//GO:0003677//GO:0016740//GO:0016788//GO:0004803//GO:0004197 omega peptidase activity//DNA binding//transferase activity//hydrolase activity, acting on ester bonds//transposase activity//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.63310 BP_3 25.06 0.88 1658 270017158 EFA13604.1 695 2.8e-70 hypothetical protein TcasGA2_TC010302 [Tribolium castaneum] -- -- -- -- -- K01413 MMP12 matrix metalloproteinase-12 (macrophage elastase) http://www.genome.jp/dbget-bin/www_bget?ko:K01413 P33435 245 1.7e-19 Collagenase 3 OS=Mus musculus GN=Mmp13 PE=1 SV=1 PF00413//PF01400 Matrixin//Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.63311 BP_3 2.00 0.59 456 645027213 XP_008211156.1 140 1.7e-06 PREDICTED: matrix metalloproteinase-16-like [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q9JHI0 126 3.0e-06 Matrix metalloproteinase-19 OS=Mus musculus GN=Mmp19 PE=2 SV=1 PF05373 L-proline 3-hydroxylase, C-terminal GO:0055114 oxidation-reduction process GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.63313 BP_3 5.25 0.63 695 270005157 EFA01605.1 315 1.3e-26 hypothetical protein TcasGA2_TC007171 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2VDY4 289 5.7e-25 UPF0609 protein C4orf27 homolog OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63320 BP_3 12.70 1.18 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6333 BP_3 1.00 1.80 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63338 BP_3 39.16 0.91 2361 478251662 ENN72116.1 746 4.8e-76 hypothetical protein YQE_11175, partial [Dendroctonus ponderosae]>gi|478262745|gb|ENN81276.1| hypothetical protein YQE_02312, partial [Dendroctonus ponderosae]>gi|546680916|gb|ERL91090.1| hypothetical protein D910_08432 [Dendroctonus ponderosae] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q1LZA1 381 4.2e-35 Carbonic anhydrase 1 OS=Bos taurus GN=CA1 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63339 BP_3 13.01 0.46 1664 642927037 XP_008195112.1 1110 2.1e-118 PREDICTED: glycosaminoglycan xylosylkinase [Tribolium castaneum]>gi|270010084|gb|EFA06532.1| hypothetical protein TcasGA2_TC009436 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95T10 691 3.3e-71 Glycosaminoglycan xylosylkinase homolog OS=Drosophila melanogaster GN=CG3631 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3829 Uncharacterized conserved protein Cluster-8309.6334 BP_3 7.23 1.95 470 189239355 XP_974286.2 312 2.0e-26 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 284 1.5e-24 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 PF00270 DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676//GO:0008026 ATP binding//nucleic acid binding//ATP-dependent helicase activity -- -- KOG0349 Putative DEAD-box RNA helicase DDX1 Cluster-8309.63346 BP_3 2.48 0.41 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63355 BP_3 51.00 25.04 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63356 BP_3 1467.00 36.98 2204 642937939 XP_969659.2 1465 1.9e-159 PREDICTED: heparan sulfate 2-O-sulfotransferase pipe [Tribolium castaneum]>gi|270015724|gb|EFA12172.1| pipe [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86BJ3 694 2.0e-71 Heparan sulfate 2-O-sulfotransferase pipe OS=Drosophila melanogaster GN=pip PE=1 SV=1 PF03567//PF00685 Sulfotransferase family//Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane KOG3922 Sulfotransferases Cluster-8309.63358 BP_3 3.00 1.93 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63359 BP_3 159.00 19.05 694 546681961 ERL91957.1 493 3.1e-47 hypothetical protein D910_09280 [Dendroctonus ponderosae] -- -- -- -- -- K11667 INO80C, IES6 INO80 complex subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K11667 Q6PI98 282 3.7e-24 INO80 complex subunit C OS=Homo sapiens GN=INO80C PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4137 Uncharacterized conserved protein Cluster-8309.6337 BP_3 5.38 0.36 1008 270297184 NP_001161900.1 269 4.2e-21 cuticular protein analogous to peritrophins 1-I precursor [Tribolium castaneum]>gi|268373732|gb|ACZ04319.1| CPAP1-I [Tribolium castaneum]>gi|270014341|gb|EFA10789.1| hypothetical protein TcasGA2_TC012766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.63375 BP_3 121.02 1.44 4339 642917423 XP_008191192.1 1857 1.3e-204 PREDICTED: serologically defined colon cancer antigen 8 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B8JK76 289 3.6e-24 Serologically defined colon cancer antigen 8 homolog OS=Danio rerio GN=Sdccag8 PE=3 SV=2 PF15964//PF05837//PF00201//PF02183//PF08702//PF02050//PF04824//PF01544 Centrosomal colon cancer autoantigen protein family//Centromere protein H (CENP-H)//UDP-glucoronosyl and UDP-glucosyl transferase//Homeobox associated leucine zipper//Fibrinogen alpha/beta chain family//Flagellar FliJ protein//Conserved region of Rad21 / Rec8 like protein//CorA-like Mg2+ transporter protein GO:0006355//GO:0055085//GO:0007165//GO:0051382//GO:0051258//GO:0030168//GO:0006935//GO:0030001//GO:0008152//GO:0071973//GO:0051297 regulation of transcription, DNA-templated//transmembrane transport//signal transduction//kinetochore assembly//protein polymerization//platelet activation//chemotaxis//metal ion transport//metabolic process//bacterial-type flagellum-dependent cell motility//centrosome organization GO:0005102//GO:0043565//GO:0003700//GO:0016758//GO:0003774//GO:0046873//GO:0030674 receptor binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring hexosyl groups//motor activity//metal ion transmembrane transporter activity//protein binding, bridging GO:0000228//GO:0009288//GO:0005577//GO:0000776//GO:0016020//GO:0005813//GO:0005667 nuclear chromosome//bacterial-type flagellum//fibrinogen complex//kinetochore//membrane//centrosome//transcription factor complex -- -- Cluster-8309.63381 BP_3 10784.80 1400.02 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63382 BP_3 10.00 0.39 1517 642913313 XP_008195230.1 177 2.9e-10 PREDICTED: amphiphysin isoform X3 [Tribolium castaneum]>gi|270002987|gb|EEZ99434.1| hypothetical protein TcasGA2_TC030600 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0019904 protein domain specific binding GO:0005737 cytoplasm -- -- Cluster-8309.63384 BP_3 222.42 3.44 3406 642916500 XP_008191068.1 1869 4.2e-206 PREDICTED: paired box protein Pax-5 [Tribolium castaneum] 642916499 XM_008192846.1 626 0 PREDICTED: Tribolium castaneum paired box protein Pax-5 (LOC656415), mRNA K15608 PAX2 paired box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15608 O57685 656 7.8e-67 Paired box protein Pax-2-A OS=Xenopus laevis GN=pax2-a PE=2 SV=2 PF00292 'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.63394 BP_3 20.40 1.32 1034 478256643 ENN76825.1 205 1.1e-13 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N3L3 145 4.2e-08 Beta-taxilin OS=Homo sapiens GN=TXLNB PE=1 SV=3 PF00548//PF09728 3C cysteine protease (picornain 3C)//Myosin-like coiled-coil protein GO:0006508 proteolysis GO:0019905//GO:0004197 syntaxin binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.63408 BP_3 15.00 0.54 1628 602731422 XP_007451114.1 747 2.5e-76 PREDICTED: histone H3.3-like [Lipotes vexillifer] 744066864 NM_005324.4 1608 0 Homo sapiens H3 histone, family 3B (H3.3B) (H3F3B), mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 Q6PI20 676 1.8e-69 Histone H3.3 OS=Danio rerio GN=h3f3a PE=2 SV=3 PF15715//PF00125 PCNA-associated factor//Core histone H2A/H2B/H3/H4 GO:0006974//GO:0051726 cellular response to DNA damage stimulus//regulation of cell cycle GO:0003677 DNA binding -- -- KOG1745 Histones H3 and H4 Cluster-8309.63409 BP_3 19.86 0.38 2791 646716704 KDR19844.1 661 4.1e-66 hypothetical protein L798_05910 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W440 592 1.7e-59 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.63410 BP_3 12.42 0.74 1101 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63412 BP_3 11.00 0.36 1751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63431 BP_3 21.66 0.38 3045 270007722 EFA04170.1 884 6.2e-92 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5FWL4 476 5.2e-46 Extended synaptotagmin-2-A OS=Xenopus laevis GN=esyt2-a PE=2 SV=1 PF17047//PF00168 Synaptotagmin-like mitochondrial-lipid-binding domain//C2 domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.63437 BP_3 100.00 2.79 2021 642932281 XP_008197046.1 172 1.5e-09 PREDICTED: uncharacterized protein LOC103314045 [Tribolium castaneum]>gi|270011627|gb|EFA08075.1| hypothetical protein TcasGA2_TC005671 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16752 Tubulin-specific chaperone C N-terminal domain -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex -- -- Cluster-8309.6344 BP_3 10133.25 435.21 1414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63445 BP_3 93.46 0.64 7292 270014787 EFA11235.1 3899 0.0e+00 hypothetical protein TcasGA2_TC010767 [Tribolium castaneum] 642911510 XM_008201231.1 266 4.4977e-134 PREDICTED: Tribolium castaneum protein unc-79 homolog (LOC662785), mRNA -- -- -- -- Q9P2D8 1364 1.3e-148 Protein unc-79 homolog OS=Homo sapiens GN=UNC79 PE=2 SV=4 PF08689 Mediator complex subunit Med5 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4820 Involved in anesthetic response in C.elegans Cluster-8309.6345 BP_3 63.16 1.28 2671 478256737 ENN76918.1 293 1.8e-23 hypothetical protein YQE_06565, partial [Dendroctonus ponderosae]>gi|546672595|gb|ERL84396.1| hypothetical protein D910_01829 [Dendroctonus ponderosae] 166208658 EU177511.1 42 5.42607e-10 Pinctada fucata shematrin-1 mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63452 BP_3 31.38 0.72 2380 642935439 XP_008198009.1 1982 2.3e-219 PREDICTED: uncharacterized protein LOC100141521 [Tribolium castaneum] 642935438 XM_008199787.1 314 3.01798e-161 PREDICTED: Tribolium castaneum uncharacterized LOC100141521 (LOC100141521), mRNA K11791 DCAF15 DDB1- and CUL4-associated factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K11791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63461 BP_3 1.00 0.59 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63466 BP_3 74.07 1.52 2641 160333791 NP_001103907.1 2126 5.1e-236 eyeless [Tribolium castaneum]>gi|158187657|gb|ABW23132.1| eyeless [Tribolium castaneum] 820837347 XM_012493950.1 167 1.74742e-79 PREDICTED: Apis florea paired box protein Pax-6-like (LOC100870332), mRNA K08031 PAX6 paired box protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08031 P26630 1171 1.2e-126 Paired box protein Pax-6 OS=Danio rerio GN=pax6a PE=2 SV=1 PF05920//PF00046//PF00292 Homeobox KN domain//Homeobox domain//'Paired box' domain GO:0006355//GO:0007275 regulation of transcription, DNA-templated//multicellular organismal development GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains Cluster-8309.63469 BP_3 11.65 1.11 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63471 BP_3 19.68 0.69 1676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11051 Mannosyltransferase putative GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.63475 BP_3 4.73 0.40 862 478261137 ENN80674.1 248 9.8e-19 hypothetical protein YQE_02908, partial [Dendroctonus ponderosae] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63476 BP_3 8.82 0.64 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63481 BP_3 11.00 1.10 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63484 BP_3 50.79 0.77 3471 546674875 ERL86161.1 2680 3.9e-300 hypothetical protein D910_03574 [Dendroctonus ponderosae] -- -- -- -- -- K12796 ERBB2IP, ERBIN erbb2-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12796 Q9V780 825 2.0e-86 Protein lap1 OS=Drosophila melanogaster GN=Lap1 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.63490 BP_3 1332.20 37.90 1986 642932376 XP_008197087.1 1073 4.9e-114 PREDICTED: protein NDNF [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C119 380 4.6e-35 Protein NDNF OS=Mus musculus GN=Ndnf PE=1 SV=2 PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63491 BP_3 6.00 0.53 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63493 BP_3 1.00 1.40 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63497 BP_3 1.00 1.22 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6350 BP_3 34.43 1.28 1588 478257001 ENN77165.1 586 1.2e-57 hypothetical protein YQE_06304, partial [Dendroctonus ponderosae]>gi|546675571|gb|ERL86740.1| hypothetical protein D910_04146 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3UJZ3 330 2.3e-29 Armadillo repeat-containing protein 7 OS=Mus musculus GN=Armc7 PE=2 SV=2 PF01245//PF00514//PF01157 Ribosomal protein L19//Armadillo/beta-catenin-like repeat//Ribosomal protein L21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG4646 Uncharacterized conserved protein, contains ARM repeats Cluster-8309.63509 BP_3 1.00 0.98 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63510 BP_3 65.00 5.51 860 91086635 XP_966565.1 612 6.0e-61 PREDICTED: U11/U12 small nuclear ribonucleoprotein 35 kDa protein [Tribolium castaneum]>gi|270009757|gb|EFA06205.1| hypothetical protein TcasGA2_TC009054 [Tribolium castaneum] -- -- -- -- -- K13155 SNRNP35 U11/U12 small nuclear ribonucleoprotein 35 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13155 Q05AT9 442 1.3e-42 U11/U12 small nuclear ribonucleoprotein 35 kDa protein OS=Xenopus laevis GN=snrnp35 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0097159//GO:0003676//GO:1901363 organic cyclic compound binding//nucleic acid binding//heterocyclic compound binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.63511 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63514 BP_3 47.27 2.23 1314 478258102 ENN78240.1 450 5.6e-42 hypothetical protein YQE_05391, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.63516 BP_3 15.85 0.33 2632 478256737 ENN76918.1 293 1.8e-23 hypothetical protein YQE_06565, partial [Dendroctonus ponderosae]>gi|546672595|gb|ERL84396.1| hypothetical protein D910_01829 [Dendroctonus ponderosae] 166208658 EU177511.1 42 5.34579e-10 Pinctada fucata shematrin-1 mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63528 BP_3 6.86 0.31 1361 478251033 ENN71514.1 340 3.3e-29 hypothetical protein YQE_11807, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R2S1 190 3.4e-13 Ribosomal protein S6 kinase-like 1 OS=Mus musculus GN=Rps6kl1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.63529 BP_3 73.43 19.60 472 642937855 XP_008200328.1 205 5.2e-14 PREDICTED: protein TEX261 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UWH6 145 1.9e-08 Protein TEX261 OS=Homo sapiens GN=TEX261 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63540 BP_3 23.51 0.74 1815 478258496 ENN78571.1 1771 5.2e-195 hypothetical protein YQE_04939, partial [Dendroctonus ponderosae]>gi|546677392|gb|ERL88238.1| hypothetical protein D910_05626 [Dendroctonus ponderosae] 768436038 XM_011561181.1 53 2.81251e-16 PREDICTED: Plutella xylostella PRKCA-binding protein-like (LOC105389970), mRNA -- -- -- -- Q5REH1 1182 4.2e-128 PRKCA-binding protein OS=Pongo abelii GN=PICK1 PE=2 SV=1 PF13180//PF06456//PF00595 PDZ domain//Arfaptin-like domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0019904//GO:0005515 protein domain specific binding//protein binding -- -- KOG3651 Protein kinase C, alpha binding protein Cluster-8309.63544 BP_3 2.00 1.12 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63545 BP_3 45.44 0.98 2528 765152853 XP_011486652.1 633 6.5e-63 PREDICTED: putative nuclease HARBI1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944//PF00453 BESS motif//Ribosomal protein L20 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003677//GO:0019843//GO:0003735 DNA binding//rRNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.63546 BP_3 49.63 0.35 7084 765152853 XP_011486652.1 705 8.2e-71 PREDICTED: putative nuclease HARBI1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.6355 BP_3 143.79 0.97 7409 642921556 XP_008192422.1 2567 1.1e-286 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60494 1205 3.7e-130 Cubilin OS=Homo sapiens GN=CUBN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.63551 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63552 BP_3 23.89 0.31 3966 58389743 XP_317249.2 1315 8.5e-142 AGAP008223-PA [Anopheles gambiae str. PEST]>gi|55237464|gb|EAA12458.2| AGAP008223-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- Q5T2S8 947 1.6e-100 Armadillo repeat-containing protein 4 OS=Homo sapiens GN=ARMC4 PE=1 SV=1 PF00514//PF11698//PF01602//PF02985 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region//HEAT repeat GO:0016192//GO:0015991//GO:0006886 vesicle-mediated transport//ATP hydrolysis coupled proton transport//intracellular protein transport GO:0005515//GO:0016820 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0000221 membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain KOG0167 FOG: Armadillo/beta-catenin-like repeats Cluster-8309.63557 BP_3 12.36 0.43 1686 6682321 CAB64663.1 206 1.4e-13 pedal retractor muscle myosin heavy chain [Mytilus galloprovincialis] -- -- -- -- -- -- -- -- -- P29616 180 6.0e-12 Myosin heavy chain, cardiac muscle isoform (Fragment) OS=Gallus gallus PE=1 SV=1 PF04513//PF08912 Baculovirus polyhedron envelope protein, PEP, C terminus//Rho Binding -- -- GO:0017048//GO:0005198 Rho GTPase binding//structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG0161 Myosin class II heavy chain Cluster-8309.63558 BP_3 107.04 1.36 4091 751234819 XP_011171162.1 407 1.7e-36 PREDICTED: uncharacterized protein LOC105203928 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05125//PF05485 Phage major capsid protein, P2 family//THAP domain -- -- GO:0003676 nucleic acid binding GO:0019028 viral capsid -- -- Cluster-8309.63565 BP_3 2.00 0.48 491 725576672 XP_010340417.1 548 9.1e-54 PREDICTED: uncharacterized protein LOC101045489 [Saimiri boliviensis boliviensis] 33876180 BC001410.2 491 0 Homo sapiens S100 calcium binding protein A11, mRNA (cDNA clone MGC:2149 IMAGE:3140092), complete cds -- -- -- -- P31949 538 5.4e-54 Protein S100-A11 OS=Homo sapiens GN=S100A11 PE=1 SV=2 PF12763//PF13202//PF13499//PF10591//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.63569 BP_3 10.66 0.39 1622 642920673 XP_008192516.1 176 4.1e-10 PREDICTED: troponin I 2 isoform X8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01456 140 2.5e-07 Ovarian abundant message protein OS=Ascaris suum GN=OAM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6357 BP_3 4.00 2.42 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63571 BP_3 27.87 2.15 918 642920671 XP_008192515.1 186 1.6e-11 PREDICTED: fibrous sheath CABYR-binding protein isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01456 152 5.8e-09 Ovarian abundant message protein OS=Ascaris suum GN=OAM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63573 BP_3 7.26 0.31 1435 642936028 XP_008198275.1 149 4.9e-07 PREDICTED: uncharacterized protein LOC103314324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050 Flagellar FliJ protein GO:0006935//GO:0071973 chemotaxis//bacterial-type flagellum-dependent cell motility GO:0003774 motor activity GO:0009288//GO:0016020 bacterial-type flagellum//membrane -- -- Cluster-8309.63584 BP_3 179.59 1.90 4858 91085743 XP_973670.1 2576 6.2e-288 PREDICTED: Fanconi anemia group M protein homolog [Tribolium castaneum] 884966605 XM_013137615.1 65 1.62555e-22 PREDICTED: Esox lucius Fanconi anemia, complementation group M (fancm), mRNA K10896 FANCM fanconi anemia group M protein http://www.genome.jp/dbget-bin/www_bget?ko:K10896 Q8IYD8 1231 2.3e-133 Fanconi anemia group M protein OS=Homo sapiens GN=FANCM PE=1 SV=2 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0354 DEAD-box like helicase Cluster-8309.63587 BP_3 48.00 1.10 2388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07967//PF15163 C3HC zinc finger-like//Meiosis-expressed -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.63589 BP_3 1.00 0.61 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63592 BP_3 3.00 3.30 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63593 BP_3 111.03 2.37 2551 478263509 ENN81862.1 759 1.6e-77 hypothetical protein YQE_01754, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF02601//PF04871 Outer membrane protein (OmpH-like)//Exonuclease VII, large subunit//Uso1 / p115 like vesicle tethering protein, C terminal region GO:0006308//GO:0015031//GO:0006886 DNA catabolic process//protein transport//intracellular protein transport GO:0051082//GO:0008565//GO:0008855 unfolded protein binding//protein transporter activity//exodeoxyribonuclease VII activity GO:0009318//GO:0016020//GO:0005737 exodeoxyribonuclease VII complex//membrane//cytoplasm -- -- Cluster-8309.63598 BP_3 15.50 0.51 1764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63602 BP_3 11.48 0.66 1134 291170322 ADD82417.1 298 2.1e-24 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27018 126 7.4e-06 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.63606 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63608 BP_3 111.26 1.48 3924 746851045 XP_011056028.1 1661 6.3e-182 PREDICTED: uncharacterized protein LOC105147016 isoform X4 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q9STP8 136 1.8e-06 Acyl-CoA-binding domain-containing protein 2 OS=Arabidopsis thaliana GN=ACBP2 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.63619 BP_3 4.71 0.84 562 642915022 XP_008190487.1 143 9.6e-07 PREDICTED: cubilin [Tribolium castaneum] 642915021 XM_008192265.1 136 6.05338e-63 PREDICTED: Tribolium castaneum cubilin (LOC662433), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6362 BP_3 5.00 0.34 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63626 BP_3 67.00 1.17 3062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63628 BP_3 2.00 0.35 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63631 BP_3 119.01 3.49 1937 642913527 XP_008201051.1 439 1.6e-40 PREDICTED: protein timeless homolog [Tribolium castaneum]>gi|270002773|gb|EEZ99220.1| timeout [Tribolium castaneum] -- -- -- -- -- K03155 TIMELESS timeless http://www.genome.jp/dbget-bin/www_bget?ko:K03155 Q9R1X4 210 2.3e-15 Protein timeless homolog OS=Mus musculus GN=Timeless PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1974 DNA topoisomerase I-interacting protein Cluster-8309.63633 BP_3 21.88 0.34 3434 756765737 AJM71483.1 569 2.3e-55 odorant-binding protein 9 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.63636 BP_3 10.40 0.43 1457 829834995 XP_012634098.1 631 6.4e-63 PREDICTED: zinc finger MYM-type protein 2 isoform X2 [Microcebus murinus] -- -- -- -- -- -- -- -- -- Q96DM1 282 7.8e-24 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF07975//PF01428 TFIIH C1-like domain//AN1-like Zinc finger GO:0006281 DNA repair GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.63641 BP_3 15.00 0.64 1414 826411277 XP_012542665.1 805 4.1e-83 PREDICTED: uncharacterized protein LOC105840305 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.63645 BP_3 2.00 0.38 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63647 BP_3 25.51 0.71 2031 195115427 XP_002002258.1 290 3.1e-23 GI17285 [Drosophila mojavensis]>gi|193912833|gb|EDW11700.1| GI17285 [Drosophila mojavensis] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 263 1.7e-21 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF12539//PF09229//PF00441 Chromosome segregation protein Csm1/Pcs1//Activator of Hsp90 ATPase, N-terminal//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0016627//GO:0001671//GO:0051087 oxidoreductase activity//protein binding//oxidoreductase activity, acting on the CH-CH group of donors//ATPase activator activity//chaperone binding -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.63648 BP_3 12.67 0.32 2222 195115427 XP_002002258.1 290 3.4e-23 GI17285 [Drosophila mojavensis]>gi|193912833|gb|EDW11700.1| GI17285 [Drosophila mojavensis] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 263 1.9e-21 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF09229//PF12539//PF00441 Activator of Hsp90 ATPase, N-terminal//Chromosome segregation protein Csm1/Pcs1//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0001671//GO:0051087//GO:0016491//GO:0005515//GO:0016627 ATPase activator activity//chaperone binding//oxidoreductase activity//protein binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.63652 BP_3 76.32 2.08 2056 542258197 XP_005464423.1 586 1.5e-57 PREDICTED: zinc finger protein 569-like isoform X1 [Oreochromis niloticus]>gi|542258199|ref|XP_005464424.1| PREDICTED: zinc finger protein 569-like isoform X2 [Oreochromis niloticus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 561 4.9e-56 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13465//PF16622//PF13912//PF00130//PF00096//PF07776//PF05864//PF00628 Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//PHD-finger GO:0006206//GO:0035556//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//intracellular signal transduction//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003677//GO:0003899//GO:0005515 zinc ion binding//metal ion binding//DNA binding//DNA-directed RNA polymerase activity//protein binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.63655 BP_3 3.00 0.70 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63661 BP_3 16.19 0.61 1573 478254276 ENN74530.1 844 1.4e-87 hypothetical protein YQE_08854, partial [Dendroctonus ponderosae] -- -- -- -- -- K00566 mnmA, trmU, TRMU tRNA-specific 2-thiouridylase http://www.genome.jp/dbget-bin/www_bget?ko:K00566 O75648 652 1.0e-66 Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens GN=TRMU PE=1 SV=2 PF00733//PF02568 Asparagine synthase//Thiamine biosynthesis protein (ThiI) GO:0006522//GO:0006529//GO:0006531//GO:0008033 alanine metabolic process//asparagine biosynthetic process//aspartate metabolic process//tRNA processing GO:0004810//GO:0004066 tRNA adenylyltransferase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Cluster-8309.63669 BP_3 16.00 0.32 2671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00203 Ribosomal protein S19 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.63670 BP_3 3.00 0.34 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63671 BP_3 6.00 0.49 876 16903179 AAK61417.1 149 3.0e-07 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63675 BP_3 120.43 3.57 1917 478266751 ENN82895.1 268 1.0e-20 hypothetical protein YQE_00735, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63679 BP_3 6.00 1.27 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63680 BP_3 10.00 1.09 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63682 BP_3 1.00 1.58 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63689 BP_3 1.00 0.52 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63690 BP_3 14.00 0.31 2487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63706 BP_3 1.00 5.03 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63708 BP_3 9.00 0.78 849 391335701 XP_003742228.1 445 1.4e-41 PREDICTED: uncharacterized protein LOC100899883 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14876 Respiratory growth transcriptional regulator GO:0045333 cellular respiration -- -- GO:0005739//GO:0005634 mitochondrion//nucleus -- -- Cluster-8309.63710 BP_3 11.92 0.50 1443 641649259 XP_008185329.1 285 8.4e-23 PREDICTED: uncharacterized protein LOC100573760 [Acyrthosiphon pisum] -- -- -- -- -- K06126 COQ6 ubiquinone biosynthesis monooxygenase Coq6 http://www.genome.jp/dbget-bin/www_bget?ko:K06126 Q6DF46 185 1.4e-12 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Xenopus tropicalis GN=coq6 PE=2 SV=1 PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- KOG3855 Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis Cluster-8309.63717 BP_3 505.49 4.12 6203 642934282 XP_008200924.1 2056 1.6e-227 PREDICTED: uncharacterized protein LOC103315040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C3Y4 387 2.2e-35 Kinetochore-associated protein 1 OS=Mus musculus GN=Kntc1 PE=1 SV=2 PF01125 G10 protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.63724 BP_3 10.18 0.38 1585 546684831 ERL94413.1 361 1.4e-31 hypothetical protein D910_11691 [Dendroctonus ponderosae] -- -- -- -- -- K01719 hemD, UROS uroporphyrinogen-III synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01719 P10746 184 2.0e-12 Uroporphyrinogen-III synthase OS=Homo sapiens GN=UROS PE=1 SV=1 PF11380//PF02602 Stealth protein CR2, conserved region 2//Uroporphyrinogen-III synthase HemD GO:0006783//GO:0033014//GO:0015994 heme biosynthetic process//tetrapyrrole biosynthetic process//chlorophyll metabolic process GO:0004852//GO:0016772 uroporphyrinogen-III synthase activity//transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.63725 BP_3 3.00 0.33 732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63729 BP_3 32.78 0.41 4135 91095179 XP_971501.1 964 4.4e-101 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K43 556 3.7e-55 Protein regulator of cytokinesis 1 OS=Mus musculus GN=Prc1 PE=2 SV=2 PF03999//PF06009 Microtubule associated protein (MAP65/ASE1 family)//Laminin Domain II GO:0000226//GO:0007155//GO:0000910 microtubule cytoskeleton organization//cell adhesion//cytokinesis GO:0008017 microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-8309.6373 BP_3 289.03 6.06 2592 270002254 EEZ98701.1 2172 2.3e-241 hypothetical protein TcasGA2_TC001240 [Tribolium castaneum] -- -- -- -- -- K10638 UHRF1, NP95 E3 ubiquitin-protein ligase UHRF1 http://www.genome.jp/dbget-bin/www_bget?ko:K10638 E7EZF3 1915 6.1e-213 E3 ubiquitin-protein ligase UHRF1 OS=Danio rerio GN=uhrf1 PE=1 SV=1 PF02182//PF00628//PF14634//PF00097//PF00240 SAD/SRA domain//PHD-finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ubiquitin family -- -- GO:0046872//GO:0005515//GO:0008270//GO:0042393 metal ion binding//protein binding//zinc ion binding//histone binding -- -- -- -- Cluster-8309.63735 BP_3 2.00 0.31 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04192 Utp21 specific WD40 associated putative domain GO:0006364 rRNA processing -- -- GO:0032040 small-subunit processome -- -- Cluster-8309.63736 BP_3 5.00 0.35 985 443717988 ELU08793.1 144 1.3e-06 hypothetical protein CAPTEDRAFT_204672 [Capitella teleta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63739 BP_3 4.00 0.70 568 221118209 XP_002156201.1 179 6.5e-11 PREDICTED: deoxyuridine 5'-triphosphate nucleotidohydrolase-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- P32542 159 5.5e-10 Pol polyprotein OS=Equine infectious anemia virus (isolate CL22) GN=pol PE=1 SV=1 PF00692 dUTPase GO:0046080 dUTP metabolic process GO:0016787 hydrolase activity -- -- KOG3370 dUTPase Cluster-8309.63746 BP_3 20.28 0.60 1915 642917423 XP_008191192.1 1857 5.8e-205 PREDICTED: serologically defined colon cancer antigen 8 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B8JK76 284 6.0e-24 Serologically defined colon cancer antigen 8 homolog OS=Danio rerio GN=Sdccag8 PE=3 SV=2 PF04824//PF15964//PF05837//PF02183//PF00038//PF08702//PF02050 Conserved region of Rad21 / Rec8 like protein//Centrosomal colon cancer autoantigen protein family//Centromere protein H (CENP-H)//Homeobox associated leucine zipper//Intermediate filament protein//Fibrinogen alpha/beta chain family//Flagellar FliJ protein GO:0006355//GO:0051258//GO:0051382//GO:0007165//GO:0030168//GO:0071973//GO:0051297//GO:0006935 regulation of transcription, DNA-templated//protein polymerization//kinetochore assembly//signal transduction//platelet activation//bacterial-type flagellum-dependent cell motility//centrosome organization//chemotaxis GO:0003700//GO:0043565//GO:0005102//GO:0005198//GO:0030674//GO:0003774 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//receptor binding//structural molecule activity//protein binding, bridging//motor activity GO:0005577//GO:0009288//GO:0000228//GO:0005882//GO:0005813//GO:0016020//GO:0000776//GO:0005667 fibrinogen complex//bacterial-type flagellum//nuclear chromosome//intermediate filament//centrosome//membrane//kinetochore//transcription factor complex -- -- Cluster-8309.63749 BP_3 2.00 0.33 585 -- -- -- -- -- 462310603 APGK01047265.1 38 1.89852e-08 Dendroctonus ponderosae Seq01047275, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6375 BP_3 132.06 9.19 984 826502568 XP_012542316.1 141 2.9e-06 PREDICTED: uncharacterized protein LOC105840098 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.63760 BP_3 13.00 0.45 1678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63772 BP_3 17.00 0.62 1622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63775 BP_3 14.00 0.59 1430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63778 BP_3 6.00 1.53 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6379 BP_3 38.88 0.34 5754 642931730 XP_008196706.1 1628 6.2e-178 PREDICTED: uncharacterized protein LOC656959 isoform X1 [Tribolium castaneum] 642931729 XM_008198484.1 233 7.8403e-116 PREDICTED: Tribolium castaneum uncharacterized LOC656959 (LOC656959), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63795 BP_3 7.36 1.25 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63798 BP_3 6.15 0.41 1022 642912341 XP_008199603.1 389 5.2e-35 PREDICTED: DNA polymerase delta catalytic subunit [Tribolium castaneum]>gi|270002921|gb|EEZ99368.1| DNA polymerase delta [Tribolium castaneum] -- -- -- -- -- K02327 POLD1 DNA polymerase delta subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02327 P54358 324 7.3e-29 DNA polymerase delta catalytic subunit OS=Drosophila melanogaster GN=DNApol-delta PE=2 SV=2 PF00136 DNA polymerase family B GO:0006260 DNA replication GO:0003887//GO:0000166//GO:0003677 DNA-directed DNA polymerase activity//nucleotide binding//DNA binding GO:0042575 DNA polymerase complex KOG0969 DNA polymerase delta, catalytic subunit Cluster-8309.638 BP_3 6.00 0.68 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63803 BP_3 1.00 0.31 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6381 BP_3 5.55 0.62 725 478252941 ENN73325.1 556 1.6e-54 hypothetical protein YQE_10087, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63811 BP_3 3.00 0.48 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63830 BP_3 20.73 0.60 1951 642914178 XP_008201577.1 300 2.1e-24 PREDICTED: spindle pole body component 110-like [Tribolium castaneum]>gi|270001578|gb|EEZ98025.1| hypothetical protein TcasGA2_TC000425 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03800 Nuf2 family GO:0007067 mitotic nuclear division -- -- GO:0000775 chromosome, centromeric region -- -- Cluster-8309.63839 BP_3 45.19 0.51 4595 91089363 XP_973168.1 1457 3.4e-158 PREDICTED: protein CIP2A [Tribolium castaneum]>gi|270011435|gb|EFA07883.1| hypothetical protein TcasGA2_TC005457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63840 BP_3 2.00 0.36 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00737 Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0042301 phosphate ion binding GO:0009523//GO:0016020 photosystem II//membrane -- -- Cluster-8309.63846 BP_3 4.00 0.88 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63856 BP_3 24.13 0.59 2250 332373676 AEE61979.1 249 2.0e-18 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63858 BP_3 2.00 0.92 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63863 BP_3 29.82 0.56 2837 642939560 XP_008197597.1 200 1.2e-12 PREDICTED: uncharacterized protein LOC103314177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.63865 BP_3 62.71 1.50 2306 328699348 XP_003240910.1 342 3.3e-29 PREDICTED: uncharacterized protein LOC100571439 [Acyrthosiphon pisum] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P02518 224 6.5e-17 Heat shock protein 27 OS=Drosophila melanogaster GN=Hsp27 PE=1 SV=2 PF05485//PF03896 THAP domain//Translocon-associated protein (TRAP), alpha subunit -- -- GO:0003676 nucleic acid binding GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.63866 BP_3 3.00 0.51 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6387 BP_3 556.42 8.59 3415 91093417 XP_967777.1 670 4.5e-67 PREDICTED: RNA-binding protein 8A [Tribolium castaneum]>gi|270015421|gb|EFA11869.1| tsunagi [Tribolium castaneum] -- -- -- -- -- K12876 RBM8A, Y14 RNA-binding protein 8A http://www.genome.jp/dbget-bin/www_bget?ko:K12876 Q5D018 455 1.6e-43 RNA-binding protein 8A OS=Danio rerio GN=rbm8a PE=2 SV=1 PF00076//PF00478 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//IMP dehydrogenase / GMP reductase domain GO:0006396//GO:0055114 RNA processing//oxidation-reduction process GO:0003676//GO:0000166//GO:0003723//GO:0003824 nucleic acid binding//nucleotide binding//RNA binding//catalytic activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily) Cluster-8309.63877 BP_3 14.27 0.37 2149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6388 BP_3 9.00 0.47 1213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63885 BP_3 36.51 0.99 2076 223671402 FAA00653.1 278 7.8e-22 TPA: putative cuticle protein [Bombyx mori] 346714934 AK383109.1 72 8.84045e-27 Bombyx mori mRNA, clone: fepM27L05 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63886 BP_3 5.00 0.46 811 847169688 XP_012808413.1 141 2.4e-06 PREDICTED: general transcription factor II-I repeat domain-containing protein 2A-like [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63894 BP_3 60.27 1.12 2888 478258661 ENN78711.1 2535 2.1e-283 hypothetical protein YQE_04883, partial [Dendroctonus ponderosae]>gi|546674933|gb|ERL86210.1| hypothetical protein D910_03621 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5JVL4 1261 4.6e-137 EF-hand domain-containing protein 1 OS=Homo sapiens GN=EFHC1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0043 Uncharacterized conserved protein, contains DM10 domain Cluster-8309.639 BP_3 4.00 0.32 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63904 BP_3 84.22 3.24 1543 91085613 XP_969487.1 818 1.4e-84 PREDICTED: uncharacterized protein C2orf47 homolog, mitochondrial [Tribolium castaneum]>gi|270010037|gb|EFA06485.1| hypothetical protein TcasGA2_TC009382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AY04 189 5.0e-13 Uncharacterized protein C2orf47 homolog, mitochondrial OS=Rattus norvegicus PE=2 SV=1 PF07961 MBA1-like protein GO:0032979 protein insertion into mitochondrial membrane from inner side -- -- GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.63910 BP_3 41.02 1.27 1843 642925861 XP_008190588.1 1004 4.5e-106 PREDICTED: osmotic avoidance abnormal protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P46873 372 3.6e-34 Osmotic avoidance abnormal protein 3 OS=Caenorhabditis elegans GN=osm-3 PE=2 SV=4 PF01618//PF01303 MotA/TolQ/ExbB proton channel family//Egg lysin (Sperm-lysin) GO:0015031//GO:0006810//GO:0007338 protein transport//transport//single fertilization GO:0008565 protein transporter activity GO:0016020 membrane KOG4280 Kinesin-like protein Cluster-8309.63911 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63916 BP_3 75.65 16.77 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02230 Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.63918 BP_3 3.00 0.79 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6393 BP_3 19.05 2.31 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63930 BP_3 2.00 0.43 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63940 BP_3 15.33 0.87 1138 642920227 XP_008192256.1 683 4.7e-69 PREDICTED: uncharacterized protein LOC103312696 [Tribolium castaneum]>gi|270006038|gb|EFA02486.1| hypothetical protein TcasGA2_TC008181 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63941 BP_3 196.85 2.53 4044 642915681 XP_008190757.1 2817 0.0e+00 PREDICTED: kin of IRRE-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RW7 196 2.0e-13 Hemicentin-1 OS=Homo sapiens GN=HMCN1 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63946 BP_3 34.13 0.66 2776 478263132 ENN81525.1 709 1.1e-71 hypothetical protein YQE_02054, partial [Dendroctonus ponderosae]>gi|546681765|gb|ERL91791.1| hypothetical protein D910_09116, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q32PN7 182 5.8e-12 Zinc finger protein DZIP1L OS=Danio rerio GN=dzip1l PE=2 SV=1 PF13912//PF06689//PF00096//PF13465 C2H2-type zinc finger//ClpX C4-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046983//GO:0046872//GO:0008270 protein dimerization activity//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.63950 BP_3 29.95 0.92 1855 642928186 XP_008195482.1 1137 1.7e-121 PREDICTED: retinol dehydrogenase 12-like [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8NBN7 713 1.0e-73 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- -- -- Cluster-8309.63952 BP_3 50.00 7.74 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63962 BP_3 5.00 8.08 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63965 BP_3 952.53 25.86 2067 642920394 XP_008192328.1 347 7.8e-30 PREDICTED: uncharacterized protein LOC103312721 isoform X1 [Tribolium castaneum]>gi|270005235|gb|EFA01683.1| hypothetical protein TcasGA2_TC007257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63967 BP_3 35.00 1.08 1860 478256721 ENN76902.1 1106 6.8e-118 hypothetical protein YQE_06550, partial [Dendroctonus ponderosae]>gi|546681295|gb|ERL91409.1| hypothetical protein D910_08741 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03206 Nitrogen fixation protein NifW GO:0009399 nitrogen fixation -- -- -- -- -- -- Cluster-8309.63972 BP_3 13.00 0.53 1469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63976 BP_3 7.73 1.22 596 478263935 ENN82101.1 362 4.1e-32 hypothetical protein YQE_01533, partial [Dendroctonus ponderosae] -- -- -- -- -- K11416 SIRT6, SIR2L6 mono-ADP-ribosyltransferase sirtuin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11416 Q9VH08 309 2.3e-27 NAD-dependent protein deacetylase Sirt6 OS=Drosophila melanogaster GN=Sirt6 PE=2 SV=1 PF02146 Sir2 family -- -- GO:0070403 NAD+ binding -- -- KOG1905 Class IV sirtuins (SIR2 family) Cluster-8309.63977 BP_3 7350.73 56.86 6523 242005002 XP_002423364.1 1740 7.3e-191 hormone receptor hr3, putative [Pediculus humanus corporis]>gi|212506394|gb|EEB10626.1| hormone receptor hr3, putative [Pediculus humanus corporis] 642929407 XM_008197603.1 666 0 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X3, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P31396 779 8.2e-81 Probable nuclear hormone receptor HR3 OS=Drosophila melanogaster GN=Hr46 PE=2 SV=1 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0009987//GO:0006355//GO:0043401 cellular process//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0005488//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4216 Steroid hormone nuclear receptor Cluster-8309.63979 BP_3 28.86 0.61 2560 270014400 EFA10848.1 1001 1.4e-105 hypothetical protein TcasGA2_TC001625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00599 Influenza Matrix protein (M2) GO:0015992 proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0055036//GO:0033644 virion membrane//host cell membrane -- -- Cluster-8309.63993 BP_3 1963.36 15.57 6370 546681025 ERL91190.1 1905 5.2e-210 hypothetical protein D910_08529 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0S8 265 3.2e-21 Leukocyte elastase inhibitor OS=Xenopus tropicalis GN=serpinb1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63995 BP_3 18.84 0.54 1958 642937652 XP_966876.3 600 3.4e-59 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62836 366 1.9e-33 Zinc finger X-chromosomal protein OS=Bos taurus GN=ZFX PE=2 SV=2 PF02150//PF06784//PF13465//PF00096 RNA polymerases M/15 Kd subunit//Uncharacterised protein family (UPF0240)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006144//GO:0006351//GO:0006206//GO:0032981 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//mitochondrial respiratory chain complex I assembly GO:0003677//GO:0003899//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//metal ion binding GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.63996 BP_3 5.00 0.56 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64002 BP_3 1.00 0.54 379 686769231 XP_002832742.2 478 9.2e-46 PREDICTED: mitotic-spindle organizing protein 2B isoform X1 [Pongo abelii] 283806587 NM_025029.3 373 0 Homo sapiens mitotic spindle organizing protein 2B (MZT2B), mRNA K16574 MZT2A_B mitotic-spindle organizing protein 2A/2B http://www.genome.jp/dbget-bin/www_bget?ko:K16574 Q6P582 474 1.1e-46 Mitotic-spindle organizing protein 2A OS=Homo sapiens GN=MZT2A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64010 BP_3 9.00 0.55 1087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64011 BP_3 2.80 0.82 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04272 Phospholamban GO:0006816//GO:0006810 calcium ion transport//transport GO:0005246//GO:0042030 calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.64019 BP_3 58.71 1.81 1858 270005388 EFA01836.1 732 1.6e-74 hypothetical protein TcasGA2_TC007438 [Tribolium castaneum] -- -- -- -- -- K17655 MRPP3 mitochondrial ribonuclease P protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17655 O15091 411 1.1e-38 Mitochondrial ribonuclease P protein 3 OS=Homo sapiens GN=KIAA0391 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64028 BP_3 1.00 0.70 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64033 BP_3 490.73 14.74 1896 557757543 XP_005178504.1 2179 2.6e-242 PREDICTED: putative adenosylhomocysteinase 2 [Musca domestica]>gi|755860451|ref|XP_011290496.1| PREDICTED: putative adenosylhomocysteinase 2 [Musca domestica] 821118450 XM_004463226.2 207 7.24922e-102 PREDICTED: Dasypus novemcinctus adenosylhomocysteinase-like 2 (AHCYL2), transcript variant X6, mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q96HN2 1977 2.9e-220 Adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1 PF07851//PF07992//PF05221//PF13241//PF02254//PF02882//PF02826 TMPIT-like protein//Pyridine nucleotide-disulphide oxidoreductase//S-adenosyl-L-homocysteine hydrolase//Putative NAD(P)-binding//TrkA-N domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0006555//GO:0006779//GO:0006730//GO:0006813//GO:0046487//GO:0009396//GO:0019354 oxidation-reduction process//methionine metabolic process//porphyrin-containing compound biosynthetic process//one-carbon metabolic process//potassium ion transport//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//siroheme biosynthetic process GO:0051287//GO:0004013//GO:0004488//GO:0016491//GO:0003824//GO:0043115 NAD binding//adenosylhomocysteinase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity//catalytic activity//precorrin-2 dehydrogenase activity GO:0016021 integral component of membrane KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.64034 BP_3 4.00 0.65 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64039 BP_3 74.67 1.27 3123 546677399 ERL88242.1 236 8.7e-17 hypothetical protein D910_05630, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08727//PF04827 Poliovirus 3A protein like//Plant transposon protein GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0017111//GO:0004197//GO:0016788//GO:0003968 nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//hydrolase activity, acting on ester bonds//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.64050 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04188 Mannosyltransferase (PIG-V) GO:0006506 GPI anchor biosynthetic process GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity GO:0000136 alpha-1,6-mannosyltransferase complex -- -- Cluster-8309.64064 BP_3 140.50 2.24 3317 642914926 XP_008190444.1 4957 0.0e+00 PREDICTED: protein slit isoform X1 [Tribolium castaneum] 462424845 APGK01016975.1 99 1.39086e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 3891 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF00560//PF07645//PF00008//PF13516//PF13855 Leucine Rich Repeat//Calcium-binding EGF domain//EGF-like domain//Leucine Rich repeat//Leucine rich repeat -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.64071 BP_3 168.34 4.06 2290 546673668 ERL85232.1 1445 4.1e-157 hypothetical protein D910_02653 [Dendroctonus ponderosae] -- -- -- -- -- K10746 EXO1 exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10746 Q24558 1088 4.2e-117 Exonuclease 1 OS=Drosophila melanogaster GN=tos PE=1 SV=1 PF13181//PF00867//PF00752//PF13414 Tetratricopeptide repeat//XPG I-region//XPG N-terminal domain//TPR repeat GO:0006281 DNA repair GO:0004518//GO:0005515 nuclease activity//protein binding -- -- KOG2518 5'-3' exonuclease Cluster-8309.64072 BP_3 38.39 0.84 2498 189241917 XP_971431.2 1590 6.9e-174 PREDICTED: rho GTPase-activating protein 19 isoform X1 [Tribolium castaneum]>gi|270016794|gb|EFA13240.1| hypothetical protein TcasGA2_TC001510 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INE5 272 1.9e-22 Rho GTPase-activating protein 19 OS=Xenopus laevis GN=arhgap19 PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.64086 BP_3 26.79 0.42 3362 357611789 EHJ67650.1 1131 1.6e-120 hypothetical protein KGM_11902 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64089 BP_3 2.00 0.91 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08655 DASH complex subunit Ask1 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.64095 BP_3 5.54 1.76 443 546685591 ERL95078.1 219 1.2e-15 hypothetical protein D910_12348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64101 BP_3 53.11 2.17 1470 91085987 XP_972131.1 1349 3.6e-146 PREDICTED: mitochondrial tRNA-specific 2-thiouridylase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00566 mnmA, trmU, TRMU tRNA-specific 2-thiouridylase http://www.genome.jp/dbget-bin/www_bget?ko:K00566 Q9W5B6 960 1.9e-102 Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Drosophila melanogaster GN=CG3021 PE=2 SV=3 PF02568//PF00733 Thiamine biosynthesis protein (ThiI)//Asparagine synthase GO:0006522//GO:0006529//GO:0006531//GO:0008033 alanine metabolic process//asparagine biosynthetic process//aspartate metabolic process//tRNA processing GO:0004810//GO:0004066 tRNA adenylyltransferase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Cluster-8309.64105 BP_3 19.90 1.25 1060 91086895 XP_970738.1 311 6.0e-26 PREDICTED: probable cytochrome P450 49a1 [Tribolium castaneum]>gi|270011073|gb|EFA07521.1| cytochrome P450 49A1 [Tribolium castaneum] -- -- -- -- -- K00488 CYP27A cholestanetriol 26-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00488 Q9V5L3 277 2.1e-23 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0004497//GO:0020037//GO:0005506//GO:0009055//GO:0016705 monooxygenase activity//heme binding//iron ion binding//electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.64106 BP_3 70.78 3.96 1153 91086895 XP_970738.1 1249 1.1e-134 PREDICTED: probable cytochrome P450 49a1 [Tribolium castaneum]>gi|270011073|gb|EFA07521.1| cytochrome P450 49A1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 902 7.9e-96 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0005506//GO:0004497//GO:0020037//GO:0009055//GO:0016705 iron ion binding//monooxygenase activity//heme binding//electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.64116 BP_3 5.80 0.62 746 546681102 ERL91258.1 523 1.1e-50 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64117 BP_3 4.00 0.73 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6412 BP_3 5.00 1.84 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64132 BP_3 10.00 0.50 1260 270007859 EFA04307.1 139 6.2e-06 hypothetical protein TcasGA2_TC014600 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00124 Photosynthetic reaction centre protein GO:0006118//GO:0009772//GO:0019684 obsolete electron transport//photosynthetic electron transport in photosystem II//photosynthesis, light reaction GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity -- -- -- -- Cluster-8309.64147 BP_3 1.00 0.63 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64150 BP_3 22656.49 881.19 1531 223671402 FAA00653.1 278 5.8e-22 TPA: putative cuticle protein [Bombyx mori] 346714934 AK383109.1 72 6.47982e-27 Bombyx mori mRNA, clone: fepM27L05 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64151 BP_3 8.57 0.75 839 91075968 XP_969381.1 323 1.9e-27 PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|642910393|ref|XP_008190714.1| PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|270014619|gb|EFA11067.1| hypothetical protein TcasGA2_TC004663 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64161 BP_3 1.00 0.71 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64165 BP_3 8.00 0.89 725 642938169 XP_008190998.1 254 1.7e-19 PREDICTED: G-protein coupled receptor Mth2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00002//PF05875 7 transmembrane receptor (Secretin family)//Ceramidase GO:0007186//GO:0006672//GO:0006807 G-protein coupled receptor signaling pathway//ceramide metabolic process//nitrogen compound metabolic process GO:0004930//GO:0016811 G-protein coupled receptor activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016021 integral component of membrane -- -- Cluster-8309.64173 BP_3 2.78 0.67 490 156359856 XP_001624980.1 159 1.2e-08 predicted protein [Nematostella vectensis]>gi|156211789|gb|EDO32880.1| predicted protein [Nematostella vectensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15898//PF09429//PF07544 cGMP-dependent protein kinase interacting domain//WW domain binding protein 11//RNA polymerase II transcription mediator complex subunit 9 GO:0006357//GO:0006396 regulation of transcription from RNA polymerase II promoter//RNA processing GO:0019901//GO:0001104 protein kinase binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.64177 BP_3 8.19 0.32 1518 189234808 XP_001808956.1 1168 3.6e-125 PREDICTED: uncharacterized protein LOC100142496 isoform X1 [Tribolium castaneum]>gi|270002244|gb|EEZ98691.1| hypothetical protein TcasGA2_TC001227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64183 BP_3 97.06 1.81 2881 642927240 XP_008195192.1 2310 2.6e-257 PREDICTED: DNA helicase MCM8 [Tribolium castaneum]>gi|270010001|gb|EFA06449.1| hypothetical protein TcasGA2_TC009331 [Tribolium castaneum] -- -- -- -- -- K10737 MCM8 DNA helicase MCM8 http://www.genome.jp/dbget-bin/www_bget?ko:K10737 I0IUP3 1649 4.7e-182 DNA helicase MCM8 OS=Gallus gallus GN=MCM8 PE=1 SV=1 PF01580//PF00493//PF07726//PF00971//PF00004//PF05496//PF00158//PF07728 FtsK/SpoIIIE family//MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//EIAV coat protein, gp90//ATPase family associated with various cellular activities (AAA)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//AAA domain (dynein-related subfamily) GO:0006281//GO:0006260//GO:0006355//GO:0006310 DNA repair//DNA replication//regulation of transcription, DNA-templated//DNA recombination GO:0003677//GO:0005524//GO:0008134//GO:0005198//GO:0016887//GO:0000166//GO:0009378 DNA binding//ATP binding//transcription factor binding//structural molecule activity//ATPase activity//nucleotide binding//four-way junction helicase activity GO:0005657//GO:0009379//GO:0019031//GO:0005667 replication fork//Holliday junction helicase complex//viral envelope//transcription factor complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.64185 BP_3 2.00 0.71 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.64187 BP_3 133.91 1.80 3871 123444605 XP_001311071.1 881 1.7e-91 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121892867|gb|EAX98141.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 684 5.0e-70 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.64190 BP_3 28.61 0.74 2151 91078434 XP_974803.1 577 1.7e-56 PREDICTED: uncharacterized protein LOC663674 isoform X1 [Tribolium castaneum]>gi|270003869|gb|EFA00317.1| hypothetical protein TcasGA2_TC003155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13673//PF13302//PF08445 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.64191 BP_3 19.75 0.56 1998 91078434 XP_974803.1 577 1.6e-56 PREDICTED: uncharacterized protein LOC663674 isoform X1 [Tribolium castaneum]>gi|270003869|gb|EFA00317.1| hypothetical protein TcasGA2_TC003155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13673//PF13302//PF08445//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.64198 BP_3 2.00 0.32 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64199 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.642 BP_3 18.00 38.14 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64201 BP_3 3.02 0.52 571 642913868 XP_008201196.1 189 4.5e-12 PREDICTED: leucine-rich repeat-containing protein C10orf11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D9B4 150 6.2e-09 Leucine-rich repeat-containing protein C10orf11 homolog OS=Mus musculus PE=2 SV=1 PF02963 Restriction endonuclease EcoRI GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0000287//GO:0009036//GO:0003677 magnesium ion binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.64203 BP_3 13.00 0.34 2114 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6421 BP_3 6.00 0.89 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64213 BP_3 168.31 0.88 9476 3093388 CAA06670.1 2970 0.0e+00 thr4 [Tenebrio molitor] 3093387 AJ005685.1 626 0 Tenebrio molitor mRNA for thr4 gene K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 857 1.1e-89 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.64214 BP_3 1370.92 7.20 9464 3093388 CAA06670.1 2970 0.0e+00 thr4 [Tenebrio molitor] 3093387 AJ005685.1 626 0 Tenebrio molitor mRNA for thr4 gene K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 857 1.1e-89 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.64215 BP_3 298.50 1.58 9391 3093388 CAA06670.1 2805 0.0e+00 thr4 [Tenebrio molitor] 3093387 AJ005685.1 626 0 Tenebrio molitor mRNA for thr4 gene K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 857 1.1e-89 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.64217 BP_3 275.75 1.46 9368 3093388 CAA06670.1 2970 0.0e+00 thr4 [Tenebrio molitor] 3093387 AJ005685.1 626 0 Tenebrio molitor mRNA for thr4 gene K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 857 1.1e-89 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.64218 BP_3 836.49 8.84 4855 3093388 CAA06670.1 2970 0.0e+00 thr4 [Tenebrio molitor] 3093387 AJ005685.1 626 0 Tenebrio molitor mRNA for thr4 gene K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 857 5.5e-90 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.64219 BP_3 334.24 1.75 9520 3093388 CAA06670.1 2805 0.0e+00 thr4 [Tenebrio molitor] 3093387 AJ005685.1 626 0 Tenebrio molitor mRNA for thr4 gene K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 857 1.1e-89 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.64220 BP_3 215.00 18.43 854 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64221 BP_3 1123.00 23.74 2572 -- -- -- -- -- 642913733 XM_008202918.1 111 2.296e-48 PREDICTED: Tribolium castaneum hormone receptor 4 (LOC663168), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- -- -- Cluster-8309.64222 BP_3 176.79 0.94 9387 3093388 CAA06670.1 2805 0.0e+00 thr4 [Tenebrio molitor] 3093387 AJ005685.1 626 0 Tenebrio molitor mRNA for thr4 gene K09185 NR6AN nuclear receptor subfamily 6 group A http://www.genome.jp/dbget-bin/www_bget?ko:K09185 Q9W539 857 1.1e-89 Hormone receptor 4 OS=Drosophila melanogaster GN=Hr4 PE=1 SV=4 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.64226 BP_3 4.00 0.56 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64227 BP_3 4.02 0.43 748 546684814 ERL94396.1 210 2.2e-14 hypothetical protein D910_11675 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3SWZ4 136 3.4e-07 Exosome complex component RRP45 OS=Bos taurus GN=EXOSC9 PE=2 SV=1 PF04446//PF00879 tRNAHis guanylyltransferase//Defensin propeptide GO:0006400//GO:0006952 tRNA modification//defense response GO:0000287//GO:0008193 magnesium ion binding//tRNA guanylyltransferase activity -- -- -- -- Cluster-8309.64231 BP_3 2.00 0.31 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64236 BP_3 5.00 0.35 981 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6424 BP_3 47.65 0.55 4491 795018255 XP_011859145.1 2143 9.3e-238 PREDICTED: uncharacterized protein LOC105556661 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- P20825 195 2.9e-13 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00096//PF03175 Zinc finger, C2H2 type//DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0046872//GO:0003887//GO:0000166//GO:0003677//GO:0008408 metal ion binding//DNA-directed DNA polymerase activity//nucleotide binding//DNA binding//3'-5' exonuclease activity GO:0042575 DNA polymerase complex KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.64250 BP_3 10.62 0.81 926 270008949 EFA05397.1 196 1.1e-12 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64263 BP_3 55.06 1.00 2949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64264 BP_3 62.34 1.55 2229 546672570 ERL84380.1 1339 7.8e-145 hypothetical protein D910_01810 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q99046 354 5.3e-32 Laccase-2 OS=Trametes villosa GN=LCC2 PE=3 SV=1 PF00394//PF07732 Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0005507//GO:0016491 copper ion binding//oxidoreductase activity -- -- -- -- Cluster-8309.6427 BP_3 57.82 0.54 5477 91085393 XP_966738.1 2913 0.0e+00 PREDICTED: Hermansky-Pudlak syndrome 3 protein homolog [Tribolium castaneum]>gi|270008408|gb|EFA04856.1| hypothetical protein TcasGA2_TC014910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q969F9 337 1.2e-29 Hermansky-Pudlak syndrome 3 protein OS=Homo sapiens GN=HPS3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64287 BP_3 7.00 1.13 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64290 BP_3 1.00 0.52 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6430 BP_3 139.00 2.62 2846 642911311 XP_008199365.1 852 3.0e-88 PREDICTED: apolipoprotein D-like [Tribolium castaneum]>gi|270014830|gb|EFA11278.1| hypothetical protein TcasGA2_TC010813 [Tribolium castaneum] -- -- -- -- -- K03098 APOD apolipoprotein D and lipocalin family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03098 P05090 305 3.3e-26 Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 PF03973//PF13417 Triabin//Glutathione S-transferase, N-terminal domain GO:0030682 evasion or tolerance of host defense response GO:0005515//GO:0031409 protein binding//pigment binding GO:0005576 extracellular region KOG4824 Apolipoprotein D/Lipocalin Cluster-8309.64303 BP_3 1.00 0.46 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64320 BP_3 38.82 2.01 1225 642914592 XP_972516.3 489 1.6e-46 PREDICTED: putative peptidyl-tRNA hydrolase PTRHD1 [Tribolium castaneum]>gi|270002266|gb|EEZ98713.1| hypothetical protein TcasGA2_TC001254 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ85 330 1.8e-29 Putative peptidyl-tRNA hydrolase PTRHD1 OS=Bos taurus GN=PTRHD1 PE=2 SV=2 PF07690//PF01981 Major Facilitator Superfamily//Peptidyl-tRNA hydrolase PTH2 GO:0055085//GO:0006470//GO:0006570//GO:0035335 transmembrane transport//protein dephosphorylation//tyrosine metabolic process//peptidyl-tyrosine dephosphorylation GO:0004045//GO:0004725 aminoacyl-tRNA hydrolase activity//protein tyrosine phosphatase activity GO:0016021 integral component of membrane KOG3305 Uncharacterized conserved protein Cluster-8309.64325 BP_3 10.00 2.09 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64334 BP_3 3.00 0.46 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6434 BP_3 82.39 7.11 850 330417871 NP_001193391.1 545 3.5e-53 protein JTB [Tribolium castaneum]>gi|270010442|gb|EFA06890.1| hypothetical protein TcasGA2_TC009835 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05439 Jumping translocation breakpoint protein (JTB) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.64344 BP_3 491.68 8.27 3156 642913840 XP_008201181.1 561 1.8e-54 PREDICTED: uncharacterized protein LOC103315106 [Tribolium castaneum]>gi|270001659|gb|EEZ98106.1| hypothetical protein TcasGA2_TC000521 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64345 BP_3 11.00 0.82 940 -- -- -- -- -- 462344665 APGK01034959.1 80 1.40191e-31 Dendroctonus ponderosae Seq01034969, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64346 BP_3 3675.34 77.48 2578 642913840 XP_008201181.1 561 1.5e-54 PREDICTED: uncharacterized protein LOC103315106 [Tribolium castaneum]>gi|270001659|gb|EEZ98106.1| hypothetical protein TcasGA2_TC000521 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64348 BP_3 44.50 0.49 4647 642921498 XP_008192894.1 2415 2.8e-269 PREDICTED: uncharacterized protein LOC103312877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08360 QacR-like protein, C-terminal region GO:0045892 negative regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.64352 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64362 BP_3 1.00 0.56 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64363 BP_3 7.00 1.17 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64364 BP_3 6.00 0.31 1233 10880979 NP_002330.1 1566 2.1e-171 lymphocyte-specific protein 1 isoform 1 [Homo sapiens]>gi|462553|sp|P33241.1|LSP1_HUMAN RecName: Full=Lymphocyte-specific protein 1; AltName: Full=47 kDa actin-binding protein; AltName: Full=52 kDa phosphoprotein; Short=pp52; AltName: Full=Lymphocyte-specific antigen WP34>gi|307139|gb|AAA59534.1| lymphocyte-specific protein 1 (LSP1) [Homo sapiens]>gi|49456417|emb|CAG46529.1| LSP1 [Homo sapiens]>gi|49456467|emb|CAG46554.1| LSP1 [Homo sapiens] 61742787 NM_002339.2 1233 0 Homo sapiens lymphocyte-specific protein 1 (LSP1), transcript variant 1, mRNA K14957 LSP1 lymphocyte-specific protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14957 P33241 1566 8.5e-173 Lymphocyte-specific protein 1 OS=Homo sapiens GN=LSP1 PE=1 SV=1 PF15202 Adipogenin GO:0006935//GO:0006968//GO:0006928//GO:0007165//GO:0045444 chemotaxis//cellular defense response//movement of cell or subcellular component//signal transduction//fat cell differentiation GO:0003779//GO:0004871 actin binding//signal transducer activity GO:0005886//GO:0015629 plasma membrane//actin cytoskeleton -- -- Cluster-8309.64370 BP_3 145.47 3.83 2124 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64371 BP_3 18.32 6.14 435 642918767 XP_008191575.1 163 3.6e-09 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64376 BP_3 1.00 0.90 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64382 BP_3 2.00 0.95 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64388 BP_3 1.00 0.62 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64391 BP_3 1.24 0.50 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF16622//PF00412//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//LIM domain//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.64398 BP_3 6.00 1.96 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64399 BP_3 55.45 2.33 1440 91077544 XP_971725.1 1412 1.7e-153 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X1 [Tribolium castaneum] 642914119 XM_008203330.1 396 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q12923 206 5.0e-15 Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6440 BP_3 1.00 0.60 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64404 BP_3 43.34 1.11 2177 668460986 KFB48581.1 363 1.1e-31 AGAP007074-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757//PF00892 Acyltransferase family//EamA-like transporter family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.64410 BP_3 17.33 0.42 2271 478255416 ENN75638.1 1228 5.9e-132 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 917 2.8e-97 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.64419 BP_3 2.00 0.57 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6443 BP_3 141.25 5.06 1636 478252123 ENN72554.1 1227 5.6e-132 hypothetical protein YQE_10894, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 447 6.4e-43 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF02724//PF07776//PF02535 Zinc finger, C2H2 type//Zinc-finger double domain//CDC45-like protein//Zinc-finger associated domain (zf-AD)//ZIP Zinc transporter GO:0055085//GO:0030001//GO:0006270 transmembrane transport//metal ion transport//DNA replication initiation GO:0046873//GO:0008270//GO:0046872 metal ion transmembrane transporter activity//zinc ion binding//metal ion binding GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.6444 BP_3 4.75 0.53 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF02724 Zinc-finger associated domain (zf-AD)//CDC45-like protein GO:0006270 DNA replication initiation GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.64442 BP_3 5.13 0.44 850 478256457 ENN76642.1 289 1.7e-23 hypothetical protein YQE_06821, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09019 EcoRII C terminal GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.64445 BP_3 30.32 0.57 2850 642937826 XP_008200317.1 1902 5.2e-210 PREDICTED: putative methyltransferase NSUN7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14AW5 222 1.4e-16 Putative methyltransferase NSUN7 OS=Mus musculus GN=Nsun7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64446 BP_3 1.00 0.41 409 861610178 KMQ85078.1 388 2.7e-35 dna-mediated transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12940 Recombination-activation protein 1 (RAG1) GO:0033151 V(D)J recombination GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.64447 BP_3 36.00 0.69 2806 861610178 KMQ85078.1 1570 1.6e-171 dna-mediated transposase [Lasius niger] 690065519 LM583733.1 217 2.97796e-107 Haemonchus placei genome assembly H_placei_MHpl1 ,scaffold HPLM_scaffold0000678 -- -- -- -- Q53H47 140 4.4e-07 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF12940 Recombination-activation protein 1 (RAG1) GO:0033151 V(D)J recombination GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.64448 BP_3 9.00 1.23 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6445 BP_3 2.00 0.38 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64456 BP_3 11.00 0.44 1486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64457 BP_3 47.30 4.72 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64471 BP_3 5.10 0.33 1046 478252139 ENN72569.1 267 7.4e-21 hypothetical protein YQE_10794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04111//PF06009//PF05929//PF01496//PF14942//PF01920//PF01576//PF09177//PF10473//PF06160//PF10018//PF07926//PF03836//PF02601 Autophagy protein Apg6//Laminin Domain II//Phage capsid scaffolding protein (GPO) serine peptidase//V-type ATPase 116kDa subunit family//Organelle biogenesis, Muted-like protein//Prefoldin subunit//Myosin tail//Syntaxin 6, N-terminal//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Vitamin-D-receptor interacting Mediator subunit 4//TPR/MLP1/MLP2-like protein//RasGAP C-terminus//Exonuclease VII, large subunit GO:0007264//GO:0048193//GO:0000921//GO:0015992//GO:0006357//GO:0006606//GO:0006308//GO:0019069//GO:0007155//GO:0015991//GO:0006457//GO:0006914 small GTPase mediated signal transduction//Golgi vesicle transport//septin ring assembly//proton transport//regulation of transcription from RNA polymerase II promoter//protein import into nucleus//DNA catabolic process//viral capsid assembly//cell adhesion//ATP hydrolysis coupled proton transport//protein folding//autophagy GO:0003774//GO:0001104//GO:0051082//GO:0045502//GO:0008134//GO:0042803//GO:0008855//GO:0015078//GO:0005096 motor activity//RNA polymerase II transcription cofactor activity//unfolded protein binding//dynein binding//transcription factor binding//protein homodimerization activity//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//GTPase activator activity GO:0031083//GO:0005667//GO:0030286//GO:0016592//GO:0016272//GO:0009318//GO:0030133//GO:0033179//GO:0016020//GO:0005940//GO:0016459//GO:0016021 BLOC-1 complex//transcription factor complex//dynein complex//mediator complex//prefoldin complex//exodeoxyribonuclease VII complex//transport vesicle//proton-transporting V-type ATPase, V0 domain//membrane//septin ring//myosin complex//integral component of membrane -- -- Cluster-8309.64472 BP_3 9.34 0.36 1532 478252139 ENN72569.1 267 1.1e-20 hypothetical protein YQE_10794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09177//PF10473//PF03836//PF10018//PF07926//PF00769//PF06156//PF04111//PF07851//PF06009//PF15180//PF14942//PF01496//PF01576//PF01920 Syntaxin 6, N-terminal//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//RasGAP C-terminus//Vitamin-D-receptor interacting Mediator subunit 4//TPR/MLP1/MLP2-like protein//Ezrin/radixin/moesin family//Protein of unknown function (DUF972)//Autophagy protein Apg6//TMPIT-like protein//Laminin Domain II//Neuropeptides B and W//Organelle biogenesis, Muted-like protein//V-type ATPase 116kDa subunit family//Myosin tail//Prefoldin subunit GO:0007155//GO:0006457//GO:0015991//GO:0007165//GO:0006914//GO:0007264//GO:0048193//GO:0006260//GO:0006357//GO:0006606//GO:0015992 cell adhesion//protein folding//ATP hydrolysis coupled proton transport//signal transduction//autophagy//small GTPase mediated signal transduction//Golgi vesicle transport//DNA replication//regulation of transcription from RNA polymerase II promoter//protein import into nucleus//proton transport GO:0042803//GO:0015078//GO:0005096//GO:0003774//GO:0001104//GO:0008092//GO:0001664//GO:0051082//GO:0045502//GO:0008134 protein homodimerization activity//hydrogen ion transmembrane transporter activity//GTPase activator activity//motor activity//RNA polymerase II transcription cofactor activity//cytoskeletal protein binding//G-protein coupled receptor binding//unfolded protein binding//dynein binding//transcription factor binding GO:0016020//GO:0030133//GO:0033179//GO:0005737//GO:0016459//GO:0016021//GO:0031083//GO:0030286//GO:0016592//GO:0005667//GO:0016272//GO:0019898 membrane//transport vesicle//proton-transporting V-type ATPase, V0 domain//cytoplasm//myosin complex//integral component of membrane//BLOC-1 complex//dynein complex//mediator complex//transcription factor complex//prefoldin complex//extrinsic component of membrane -- -- Cluster-8309.64478 BP_3 1.00 0.45 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64480 BP_3 2.00 2.75 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06839 GRF zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.64483 BP_3 6.00 0.31 1232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64489 BP_3 15.56 0.58 1587 765147862 XP_011484596.1 488 2.7e-46 PREDICTED: zinc finger protein 883-like [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 444 1.4e-42 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF05443//PF13465//PF01428//PF13912//PF02892//PF00412//PF01155//PF00130//PF00096//PF02176 ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//AN1-like Zinc finger//C2H2-type zinc finger//BED zinc finger//LIM domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//TRAF-type zinc finger GO:0006464//GO:0006355//GO:0035556 cellular protein modification process//regulation of transcription, DNA-templated//intracellular signal transduction GO:0008270//GO:0003677//GO:0016151//GO:0046872 zinc ion binding//DNA binding//nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.64490 BP_3 2.00 0.96 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64499 BP_3 1.00 0.84 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.645 BP_3 157.73 7.19 1349 270006762 EFA03210.1 351 1.7e-30 hypothetical protein TcasGA2_TC013130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 260 2.6e-21 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379//PF04566 Insect cuticle protein//RNA polymerase Rpb2, domain 4 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0042302//GO:0003677//GO:0003899 structural constituent of cuticle//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.6450 BP_3 25.59 1.34 1214 765147862 XP_011484596.1 475 6.6e-45 PREDICTED: zinc finger protein 883-like [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6IV72 421 4.9e-40 Zinc finger protein 425 OS=Homo sapiens GN=ZNF425 PE=1 SV=1 PF07776//PF05495//PF00096//PF16622//PF01844//PF13912//PF00412//PF02892//PF04810//PF13465 Zinc-finger associated domain (zf-AD)//CHY zinc finger//Zinc finger, C2H2 type//zinc-finger C2H2-type//HNH endonuclease//C2H2-type zinc finger//LIM domain//BED zinc finger//Sec23/Sec24 zinc finger//Zinc-finger double domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003677//GO:0004519//GO:0003676//GO:0008270//GO:0046872 DNA binding//endonuclease activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat -- -- Cluster-8309.64500 BP_3 6.00 0.54 826 478252122 ENN72553.1 422 6.2e-39 hypothetical protein YQE_10893, partial [Dendroctonus ponderosae] -- -- -- -- -- K03132 TAF7 transcription initiation factor TFIID subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03132 Q9VHY5 234 1.6e-18 Transcription initiation factor TFIID subunit 7 OS=Drosophila melanogaster GN=Taf7 PE=1 SV=1 PF04816//PF04658 tRNA (adenine(22)-N(1))-methyltransferase//TAFII55 protein conserved region GO:0009451//GO:0008033//GO:0006367 RNA modification//tRNA processing//transcription initiation from RNA polymerase II promoter GO:0016429 tRNA (adenine-N1-)-methyltransferase activity GO:0005669 transcription factor TFIID complex KOG4011 Transcription initiation factor TFIID, subunit TAF7 Cluster-8309.64501 BP_3 4.00 0.82 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64502 BP_3 3.00 0.34 713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6451 BP_3 82.45 4.65 1147 765147862 XP_011484596.1 475 6.2e-45 PREDICTED: zinc finger protein 883-like [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6P2D0 421 4.7e-40 Zinc finger protein 1 homolog OS=Homo sapiens GN=ZFP1 PE=2 SV=2 PF05495//PF00096//PF07776//PF13465//PF16622//PF01844//PF13912//PF00412 CHY zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//zinc-finger C2H2-type//HNH endonuclease//C2H2-type zinc finger//LIM domain -- -- GO:0008270//GO:0004519//GO:0003676//GO:0046872 zinc ion binding//endonuclease activity//nucleic acid binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.64510 BP_3 3.43 0.44 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64511 BP_3 60.00 1.32 2481 270002758 EEZ99205.1 813 8.6e-84 serine protease P10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 487 2.2e-47 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF05109 Trypsin//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058//GO:0006508 viral life cycle//proteolysis GO:0004252 serine-type endopeptidase activity GO:0019031 viral envelope -- -- Cluster-8309.6452 BP_3 24.00 19.29 346 765166492 XP_011492060.1 330 1.2e-28 PREDICTED: zinc finger protein 26-like isoform X1 [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86WZ6 319 9.4e-29 Zinc finger protein 227 OS=Homo sapiens GN=ZNF227 PE=1 SV=1 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.64540 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03838 Recombination protein U GO:0006310//GO:0006281 DNA recombination//DNA repair -- -- GO:0005737 cytoplasm -- -- Cluster-8309.64563 BP_3 16.43 0.38 2375 662210206 XP_008478733.1 223 2.1e-15 PREDICTED: sporozoite surface protein 2-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64565 BP_3 4.00 0.37 806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64567 BP_3 68.31 2.49 1616 861597654 KMQ83382.1 202 4.0e-13 transcription factor adf-1 [Lasius niger] -- -- -- -- -- K09427 ADF1 Adh transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09427 P05552 175 2.2e-11 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64569 BP_3 9.31 0.58 1072 817196071 XP_012273605.1 192 3.8e-12 PREDICTED: uncharacterized protein LOC105696042 isoform X1 [Orussus abietinus] -- -- -- -- -- -- -- -- -- P05552 137 3.7e-07 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 PF04719 hTAFII28-like protein conserved region GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005634 nucleus -- -- Cluster-8309.64571 BP_3 45.55 2.25 1269 861597654 KMQ83382.1 202 3.1e-13 transcription factor adf-1 [Lasius niger] -- -- -- -- -- K09427 ADF1 Adh transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09427 P05552 175 1.7e-11 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64572 BP_3 3.00 46.59 232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64579 BP_3 2.00 0.95 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64581 BP_3 5.00 0.34 1005 270004396 EFA00844.1 148 4.5e-07 hypothetical protein TcasGA2_TC003732 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF13639//PF00130//PF07065//PF00628 Zinc-finger double domain//Ring finger domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//D123//PHD-finger GO:0007049//GO:0035556 cell cycle//intracellular signal transduction GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- -- -- Cluster-8309.64584 BP_3 29.00 1.31 1359 189237979 XP_001812268.1 947 1.4e-99 PREDICTED: hydrogen peroxide stress regulator 1 [Tribolium castaneum]>gi|270008254|gb|EFA04702.1| vielfaltig [Tribolium castaneum] 642925026 XM_001812216.2 68 9.59638e-25 PREDICTED: Tribolium castaneum vielfaltig (LOC100142336), mRNA -- -- -- -- -- -- -- -- PF16622//PF13912//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.64585 BP_3 13.00 1.77 645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64590 BP_3 9.94 1.77 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64591 BP_3 2.00 0.39 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64596 BP_3 1.00 1.12 325 642914743 XP_008190334.1 222 3.8e-16 PREDICTED: uncharacterized protein LOC655834 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64599 BP_3 2.00 0.32 591 270002798 EEZ99245.1 181 3.9e-11 serine protease P19 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.646 BP_3 859.00 325.59 418 478259935 ENN79737.1 205 4.6e-14 hypothetical protein YQE_03793, partial [Dendroctonus ponderosae]>gi|546674730|gb|ERL86039.1| hypothetical protein D910_03453 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05436 Mating factor alpha precursor N-terminus GO:0007618 mating -- -- GO:0005576 extracellular region -- -- Cluster-8309.6460 BP_3 44.00 2.32 1204 752863744 XP_011268239.1 370 9.8e-33 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07267 Nucleopolyhedrovirus capsid protein P87 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.64601 BP_3 8.00 0.47 1109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64605 BP_3 23.00 0.52 2420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64606 BP_3 20.77 1.45 981 642910346 XP_970887.2 560 7.4e-55 PREDICTED: serine/threonine-protein kinase MAK isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64615 BP_3 12.00 1.17 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04813 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus GO:0045893 positive regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.64617 BP_3 3.00 0.76 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64621 BP_3 6.00 0.65 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64622 BP_3 18.00 0.99 1165 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64627 BP_3 6.00 0.75 676 478254919 ENN75153.1 353 5.1e-31 hypothetical protein YQE_08266, partial [Dendroctonus ponderosae]>gi|546670711|gb|ERL83361.1| hypothetical protein D910_00280 [Dendroctonus ponderosae]>gi|546670742|gb|ERL83375.1| hypothetical protein D910_00315 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06079 Apyrase -- -- GO:0005509//GO:0016462 calcium ion binding//pyrophosphatase activity -- -- -- -- Cluster-8309.64634 BP_3 294.55 23.34 900 478256737 ENN76918.1 293 6.2e-24 hypothetical protein YQE_06565, partial [Dendroctonus ponderosae]>gi|546672595|gb|ERL84396.1| hypothetical protein D910_01829 [Dendroctonus ponderosae] 166208658 EU177511.1 42 1.78317e-10 Pinctada fucata shematrin-1 mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64635 BP_3 39.85 0.56 3703 642928611 XP_008199978.1 1514 6.7e-165 PREDICTED: FERM domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IJ35 348 4.4e-31 FERM domain-containing protein 8 OS=Xenopus tropicalis GN=frmd8 PE=2 SV=1 PF01527//PF04218 Transposase//CENP-B N-terminal DNA-binding domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- KOG4335 FERM domain-containing protein KRIT1 Cluster-8309.64637 BP_3 1.00 0.32 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64655 BP_3 3.00 3.03 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64659 BP_3 17.31 1.22 975 642934559 XP_008197714.1 865 3.1e-90 PREDICTED: uncharacterized protein LOC658526 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O94889 221 6.1e-17 Kelch-like protein 18 OS=Homo sapiens GN=KLHL18 PE=1 SV=3 PF00651//PF03931//PF02214 BTB/POZ domain//Skp1 family, tetramerisation domain//BTB/POZ domain GO:0051260//GO:0006511 protein homooligomerization//ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.64664 BP_3 6.74 0.44 1032 642938802 XP_008199892.1 587 5.7e-58 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 458 2.1e-44 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089//PF00540 Trypsin//gag gene protein p17 (matrix protein) GO:0006508 proteolysis GO:0004252//GO:0005198 serine-type endopeptidase activity//structural molecule activity -- -- -- -- Cluster-8309.64674 BP_3 11.00 0.41 1581 642918472 XP_971273.2 1092 2.4e-116 PREDICTED: protein NDRG3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RA95 598 1.9e-60 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 PF09429 WW domain binding protein 11 GO:0006396 RNA processing -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.64675 BP_3 59.30 1.34 2422 642937007 XP_008198650.1 1275 2.2e-137 PREDICTED: neuromedin-U receptor 2-like [Tribolium castaneum]>gi|674279351|gb|AIL02854.1| G-protein coupled receptor [Tribolium castaneum]>gi|728893169|gb|AIZ00518.1| pyrokinin 1 receptor A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58CW4 502 4.0e-49 Neuromedin-U receptor 2 OS=Bos taurus GN=NMUR2 PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.64677 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64679 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64680 BP_3 33.85 0.81 2311 642922875 XP_008200434.1 935 5.7e-98 PREDICTED: uncharacterized protein LOC103314918 [Tribolium castaneum]>gi|270006561|gb|EFA03009.1| hypothetical protein TcasGA2_TC010432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8K0R7 132 3.1e-06 Zinc finger protein 839 OS=Homo sapiens GN=ZNF839 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64682 BP_3 159.00 0.97 8196 642917474 XP_008191217.1 726 3.5e-73 PREDICTED: whirlin-like isoform X1 [Tribolium castaneum] 462299288 APGK01051368.1 56 2.76915e-17 Dendroctonus ponderosae Seq01051378, whole genome shotgun sequence -- -- -- -- Q9P202 240 3.2e-18 Whirlin OS=Homo sapiens GN=DFNB31 PE=1 SV=3 PF00595//PF13180//PF03614 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Repressor of phase-1 flagellin GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700 protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.64691 BP_3 3.00 0.39 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64697 BP_3 18.17 0.57 1834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05001 RNA polymerase Rpb1 C-terminal repeat GO:0006366 transcription from RNA polymerase II promoter GO:0003677 DNA binding GO:0005665 DNA-directed RNA polymerase II, core complex -- -- Cluster-8309.64707 BP_3 62.19 1.10 3015 642939902 XP_008200259.1 985 1.2e-103 PREDICTED: acidic repeat-containing protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96QF7 383 3.1e-35 Acidic repeat-containing protein OS=Homo sapiens GN=ACRC PE=2 SV=1 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0030942//GO:0008312 endoplasmic reticulum signal peptide binding//7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3854 SPRT-like metalloprotease Cluster-8309.64711 BP_3 6.00 1.24 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64712 BP_3 9.00 0.36 1491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64713 BP_3 68.01 2.59 1556 642914178 XP_008201577.1 300 1.7e-24 PREDICTED: spindle pole body component 110-like [Tribolium castaneum]>gi|270001578|gb|EEZ98025.1| hypothetical protein TcasGA2_TC000425 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03800 Nuf2 family GO:0007067 mitotic nuclear division -- -- GO:0000775 chromosome, centromeric region -- -- Cluster-8309.64714 BP_3 6.29 1.19 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64717 BP_3 3.72 0.88 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64718 BP_3 4.00 0.45 720 295981455 CBL87044.1 1218 2.7e-131 MHC class I antigen [Homo sapiens] 33187147 U02935.2 705 0 HSU02935 Homo sapiens HLA-A2 gene, enhancer region and complete cds K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P01892 1220 6.5e-133 HLA class I histocompatibility antigen, A-2 alpha chain OS=Homo sapiens GN=HLA-A PE=1 SV=1 PF00129//PF16497 Class I Histocompatibility antigen, domains alpha 1 and 2//MHC-I family domain GO:0006955 immune response -- -- -- -- -- -- Cluster-8309.64722 BP_3 30.02 1.68 1152 91092196 XP_969285.1 582 2.4e-57 PREDICTED: plasminogen receptor (KT) isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3P8 266 4.4e-22 Plasminogen receptor (KT) OS=Mus musculus GN=Plgrkt PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64727 BP_3 1.00 2.95 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64728 BP_3 39.61 0.96 2281 861603908 KMQ84131.1 479 4.2e-45 mariner mos1 transposase [Lasius niger] 795018230 XM_012003745.1 72 9.7284e-27 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556652 (LOC105556652), mRNA K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q7JQ07 361 8.4e-33 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64729 BP_3 44.58 1.05 2347 861603908 KMQ84131.1 479 4.4e-45 mariner mos1 transposase [Lasius niger] 795018230 XM_012003745.1 72 1.00143e-26 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556652 (LOC105556652), mRNA K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q7JQ07 381 4.2e-35 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6473 BP_3 9.83 0.81 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16178//PF05699 Dimerisation domain of Ca+-activated chloride-channel, anoctamin//hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.6474 BP_3 2.00 0.39 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64741 BP_3 1.00 0.74 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64747 BP_3 35.39 0.53 3491 91079140 XP_975466.1 3295 0.0e+00 PREDICTED: intraflagellar transport protein 88 homolog [Tribolium castaneum] -- -- -- -- -- K16474 IFT88 intraflagellar transport protein 88 http://www.genome.jp/dbget-bin/www_bget?ko:K16474 Q61371 1773 2.4e-196 Intraflagellar transport protein 88 homolog OS=Mus musculus GN=Ift88 PE=1 SV=2 PF13371//PF00515//PF13374//PF13181//PF13414//PF13174//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.64749 BP_3 8.98 0.54 1092 749784255 XP_011146009.1 568 9.7e-56 PREDICTED: uncharacterized protein LOC105187106, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.6475 BP_3 21.28 0.44 2645 478251072 ENN71551.1 874 7.7e-91 hypothetical protein YQE_11779, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DA80 317 1.2e-27 Radial spoke head protein 3 homolog B OS=Mus musculus GN=Rsph3b PE=2 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1337 N-methyltransferase Cluster-8309.64750 BP_3 31.59 0.37 4356 642915022 XP_008190487.1 3658 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] 642915021 XM_008192265.1 777 0 PREDICTED: Tribolium castaneum cubilin (LOC662433), mRNA -- -- -- -- Q9JLB4 403 2.2e-37 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF05393//PF02480//PF00057 Human adenovirus early E3A glycoprotein//Alphaherpesvirus glycoprotein E//Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.64753 BP_3 12.00 0.56 1319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64756 BP_3 10.00 0.51 1231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10613 Ligated ion channel L-glutamate- and glycine-binding site GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.64757 BP_3 1.00 0.34 431 270002026 EEZ98473.1 192 1.5e-12 hypothetical protein TcasGA2_TC000965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64764 BP_3 7.56 0.81 741 134053892 NP_001076809.1 825 1.0e-85 adipokinetic hormone receptor [Tribolium castaneum]>gi|642928766|ref|XP_008195552.1| PREDICTED: adipokinetic hormone receptor isoform X1 [Tribolium castaneum]>gi|90903321|gb|ABE02225.1| adipokinetic hormone receptor [Tribolium castaneum]>gi|126116536|gb|ABN79650.1| adipokinetic hormone receptor [Tribolium castaneum]>gi|270011068|gb|EFA07516.1| hypothetical protein TcasGA2_TC009772, partial [Tribolium castaneum] -- -- -- -- -- K04280 GNRHR gonadotropin-releasing hormone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04280 O42329 362 2.1e-33 Gonadotropin-releasing hormone II receptor OS=Clarias gariepinus PE=2 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0097211//GO:0007187//GO:0007186 cellular response to gonadotropin-releasing hormone//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//G-protein coupled receptor signaling pathway GO:0004968//GO:0004930 gonadotropin-releasing hormone receptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.64775 BP_3 74.78 0.61 6195 270012045 EFA08493.1 793 4.5e-81 hypothetical protein TcasGA2_TC006145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001//PF03278//PF00665//PF03175//PF01096//PF03376//PF06220 7 transmembrane receptor (rhodopsin family)//IpaB/EvcA family//Integrase core domain//DNA polymerase type B, organellar and viral//Transcription factor S-II (TFIIS)//Adenovirus E3B protein//U1 zinc finger GO:0006260//GO:0007186//GO:0015074//GO:0009405//GO:0006351 DNA replication//G-protein coupled receptor signaling pathway//DNA integration//pathogenesis//transcription, DNA-templated GO:0003676//GO:0008408//GO:0000166//GO:0008270//GO:0004930//GO:0003677//GO:0003887 nucleic acid binding//3'-5' exonuclease activity//nucleotide binding//zinc ion binding//G-protein coupled receptor activity//DNA binding//DNA-directed DNA polymerase activity GO:0016020//GO:0016021//GO:0042575 membrane//integral component of membrane//DNA polymerase complex -- -- Cluster-8309.64777 BP_3 4.00 0.56 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64783 BP_3 1.00 1.22 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64787 BP_3 35.47 0.81 2398 91095179 XP_971501.1 921 2.5e-96 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K43 534 7.7e-53 Protein regulator of cytokinesis 1 OS=Mus musculus GN=Prc1 PE=2 SV=2 PF03999//PF07649 Microtubule associated protein (MAP65/ASE1 family)//C1-like domain GO:0055114//GO:0000226//GO:0000910 oxidation-reduction process//microtubule cytoskeleton organization//cytokinesis GO:0047134//GO:0008017 protein-disulfide reductase activity//microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-8309.64788 BP_3 80.85 1.81 2447 91095179 XP_971501.1 903 3.1e-94 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K43 521 2.5e-51 Protein regulator of cytokinesis 1 OS=Mus musculus GN=Prc1 PE=2 SV=2 PF03999//PF07649 Microtubule associated protein (MAP65/ASE1 family)//C1-like domain GO:0000226//GO:0055114//GO:0000910 microtubule cytoskeleton organization//oxidation-reduction process//cytokinesis GO:0047134//GO:0008017 protein-disulfide reductase activity//microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-8309.6479 BP_3 2.00 0.33 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64790 BP_3 5.00 0.72 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64794 BP_3 15.00 1.58 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64796 BP_3 34.55 0.59 3116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64797 BP_3 37.96 0.65 3092 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.648 BP_3 9.00 1.54 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64800 BP_3 1.00 0.53 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64804 BP_3 10.07 0.59 1112 765156636 XP_011488191.1 269 4.6e-21 PREDICTED: ephrin type-A receptor 6 [Oryzias latipes] -- -- -- -- -- -- -- -- -- O08680 258 3.6e-21 Ephrin type-A receptor 3 OS=Rattus norvegicus GN=Epha3 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.6481 BP_3 6.00 0.55 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64820 BP_3 7.70 0.46 1100 478252126 ENN72557.1 173 6.2e-10 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.64838 BP_3 4.00 2.08 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64844 BP_3 10.33 0.34 1739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64847 BP_3 4.00 0.36 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64852 BP_3 14.36 0.44 1859 270012045 EFA08493.1 308 2.3e-25 hypothetical protein TcasGA2_TC006145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64854 BP_3 7.82 0.31 1521 642930372 XP_008196370.1 365 4.7e-32 PREDICTED: mothers against decapentaplegic homolog 3 [Tribolium castaneum] -- -- -- -- -- K04500 SMAD2_3 mothers against decapentaplegic homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K04500 O70436 263 1.3e-21 Mothers against decapentaplegic homolog 2 OS=Rattus norvegicus GN=Smad2 PE=1 SV=1 PF03165 MH1 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.64857 BP_3 6.00 0.46 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64866 BP_3 3.00 0.39 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64875 BP_3 4.00 1.01 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64877 BP_3 1.00 0.43 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03688 Nepovirus coat protein, C-terminal domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.6488 BP_3 9.09 0.51 1147 642927939 XP_008195454.1 196 1.4e-12 PREDICTED: uncharacterized protein LOC103313590 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64881 BP_3 15.93 0.98 1078 642926342 XP_008194886.1 1430 1.1e-155 PREDICTED: small G protein signaling modulator 1 isoform X2 [Tribolium castaneum] 462294937 APGK01052928.1 71 1.62692e-26 Dendroctonus ponderosae Seq01052938, whole genome shotgun sequence -- -- -- -- Q2NKQ1 880 2.6e-93 Small G protein signaling modulator 1 OS=Homo sapiens GN=SGSM1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1648 Uncharacterized conserved protein, contains RUN, BRK and TBC domains Cluster-8309.64883 BP_3 41.70 1.18 1999 478252210 ENN72638.1 1453 4.3e-158 hypothetical protein YQE_10736, partial [Dendroctonus ponderosae] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 Q9VPH2 968 3.0e-103 DNA primase large subunit OS=Drosophila melanogaster GN=DNApol-alpha60 PE=1 SV=2 PF00542//PF04104 Ribosomal protein L7/L12 C-terminal domain//Eukaryotic and archaeal DNA primase, large subunit GO:0006412//GO:0006351//GO:0042254//GO:0006269 translation//transcription, DNA-templated//ribosome biogenesis//DNA replication, synthesis of RNA primer GO:0003896//GO:0003735 DNA primase activity//structural constituent of ribosome GO:0005657//GO:0005730//GO:0005840 replication fork//nucleolus//ribosome KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.64884 BP_3 54.26 1.58 1946 478252210 ENN72638.1 1453 4.1e-158 hypothetical protein YQE_10736, partial [Dendroctonus ponderosae] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 Q9VPH2 968 3.0e-103 DNA primase large subunit OS=Drosophila melanogaster GN=DNApol-alpha60 PE=1 SV=2 PF00542//PF04104 Ribosomal protein L7/L12 C-terminal domain//Eukaryotic and archaeal DNA primase, large subunit GO:0042254//GO:0006269//GO:0006412//GO:0006351 ribosome biogenesis//DNA replication, synthesis of RNA primer//translation//transcription, DNA-templated GO:0003735//GO:0003896 structural constituent of ribosome//DNA primase activity GO:0005730//GO:0005840//GO:0005657 nucleolus//ribosome//replication fork KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.64888 BP_3 12.09 0.42 1688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6489 BP_3 7.00 0.32 1353 641679481 XP_008188582.1 158 4.2e-08 PREDICTED: uncharacterized protein LOC100162186 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64891 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64895 BP_3 5.00 0.39 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6490 BP_3 41.13 0.67 3231 768426896 XP_011554510.1 924 1.5e-96 PREDICTED: uncharacterized protein LOC105385776, partial [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q7M3K2 330 4.7e-29 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF04614//PF01979//PF04997 Pex19 protein family//Amidohydrolase family//RNA polymerase Rpb1, domain 1 GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0016787//GO:0003677//GO:0003899 hydrolase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005777//GO:0005730 peroxisome//nucleolus -- -- Cluster-8309.64901 BP_3 1.23 0.43 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64904 BP_3 13.02 1.03 898 728418700 AIY68378.1 423 5.2e-39 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 265 4.5e-22 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64905 BP_3 2.00 0.58 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6491 BP_3 220.46 5.17 2347 546675717 ERL86854.1 271 5.7e-21 hypothetical protein D910_04257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845//PF07776 Spore germination protein//Zinc-finger associated domain (zf-AD) GO:0009847 spore germination GO:0008270 zinc ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.64914 BP_3 31.00 0.57 2932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07243 Phlebovirus glycoprotein G1 -- -- -- -- GO:0016021//GO:0019012 integral component of membrane//virion -- -- Cluster-8309.64916 BP_3 1.00 1.97 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6492 BP_3 15.91 1.19 938 667332116 XP_008591825.1 367 1.7e-32 PREDICTED: ras-related protein Rab-27B [Galeopterus variegatus] -- -- -- -- -- K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 P23640 296 1.2e-25 Ras-related protein Rab-27A OS=Rattus norvegicus GN=Rab27a PE=1 SV=1 PF01926//PF08477//PF00071//PF00025 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.64929 BP_3 6.00 0.86 628 827561151 XP_012551394.1 223 5.6e-16 PREDICTED: protein couch potato [Bombyx mori] -- -- -- -- -- -- -- -- -- Q01617 223 2.3e-17 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.6493 BP_3 3.00 0.58 539 -- -- -- -- -- 257286307 AC236507.3 131 3.4845e-60 Biomphalaria glabrata BAC clone BG_BBa-11G10 from chromosome unknown, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64932 BP_3 35.48 0.62 3040 385199932 AFI45014.1 1315 6.5e-142 cytochrome P450 CYP411a1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P29981 623 4.7e-63 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.64944 BP_3 5.84 0.87 616 642919073 XP_008191722.1 469 1.7e-44 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 438 2.7e-42 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.64948 BP_3 112.51 7.52 1013 270014663 EFA11111.1 1629 8.4e-179 hypothetical protein TcasGA2_TC004709 [Tribolium castaneum] 642910412 XM_008192502.1 268 4.69625e-136 PREDICTED: Tribolium castaneum agrin-like (LOC100141763), mRNA K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 P31696 531 7.2e-53 Agrin OS=Gallus gallus GN=AGRN PE=1 SV=3 PF07648//PF00050//PF00008 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain//EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.64949 BP_3 62.86 2.20 1666 642910413 XP_008190724.1 1964 2.0e-217 PREDICTED: agrin-like [Tribolium castaneum] -- -- -- -- -- K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 A2ASQ1 541 8.2e-54 Agrin OS=Mus musculus GN=Agrn PE=1 SV=1 PF03146//PF00050//PF07648 Agrin NtA domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0007213//GO:0043113 G-protein coupled acetylcholine receptor signaling pathway//receptor clustering GO:0043236//GO:0005515 laminin binding//protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.64950 BP_3 40.25 1.37 1711 642910413 XP_008190724.1 1960 5.9e-217 PREDICTED: agrin-like [Tribolium castaneum] -- -- -- -- -- K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 A2ASQ1 541 8.5e-54 Agrin OS=Mus musculus GN=Agrn PE=1 SV=1 PF03146//PF07648//PF00050 Agrin NtA domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0043113//GO:0007213 receptor clustering//G-protein coupled acetylcholine receptor signaling pathway GO:0043236//GO:0005515 laminin binding//protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.64951 BP_3 60.89 2.52 1456 642910413 XP_008190724.1 1200 6.7e-129 PREDICTED: agrin-like [Tribolium castaneum] -- -- -- -- -- K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 A2ASQ1 396 4.7e-37 Agrin OS=Mus musculus GN=Agrn PE=1 SV=1 PF03146//PF07648//PF00050 Agrin NtA domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0043113//GO:0007213 receptor clustering//G-protein coupled acetylcholine receptor signaling pathway GO:0043236//GO:0005515 laminin binding//protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.64952 BP_3 2.00 0.71 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64954 BP_3 69.53 15.92 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02203 Tar ligand binding domain homologue GO:0007165//GO:0006935 signal transduction//chemotaxis GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.64956 BP_3 9.38 2.68 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6496 BP_3 3.00 0.36 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64971 BP_3 962.45 24.01 2224 649572295 NP_001280525.1 231 2.4e-16 cuticle protein precursor [Tribolium castaneum]>gi|270003230|gb|EEZ99677.1| hypothetical protein TcasGA2_TC002434 [Tribolium castaneum]>gi|334261603|gb|AEG74042.1| cuticle protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26968 145 9.1e-08 Adult-specific cuticular protein ACP-22 OS=Tenebrio molitor GN=ACP22 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64972 BP_3 1117.89 28.76 2165 649572295 NP_001280525.1 231 2.3e-16 cuticle protein precursor [Tribolium castaneum]>gi|270003230|gb|EEZ99677.1| hypothetical protein TcasGA2_TC002434 [Tribolium castaneum]>gi|334261603|gb|AEG74042.1| cuticle protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26968 145 8.9e-08 Adult-specific cuticular protein ACP-22 OS=Tenebrio molitor GN=ACP22 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64974 BP_3 96.39 1.87 2771 642913062 XP_008201373.1 548 5.1e-53 PREDICTED: uncharacterized protein LOC103315170 [Tribolium castaneum]>gi|270001839|gb|EEZ98286.1| hypothetical protein TcasGA2_TC000734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00243 Nerve growth factor family GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.64975 BP_3 61.61 1.18 2800 642913062 XP_008201373.1 548 5.2e-53 PREDICTED: uncharacterized protein LOC103315170 [Tribolium castaneum]>gi|270001839|gb|EEZ98286.1| hypothetical protein TcasGA2_TC000734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00243 Nerve growth factor family GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.64979 BP_3 2.00 0.36 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64981 BP_3 474.43 9.83 2619 91080175 XP_970509.1 607 7.0e-60 PREDICTED: organic solute transporter alpha-like protein [Tribolium castaneum]>gi|270005672|gb|EFA02120.1| hypothetical protein TcasGA2_TC007767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VVV2 175 3.6e-11 Organic solute transporter alpha-like protein OS=Drosophila melanogaster GN=CG6836 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64982 BP_3 2154.97 110.00 1236 166947675 ABZ04124.1 368 1.7e-32 putative cuticle protein CP7 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P82166 245 1.3e-19 Cuticle protein 19.8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.64984 BP_3 60096.66 2936.96 1278 649572295 NP_001280525.1 287 4.4e-23 cuticle protein precursor [Tribolium castaneum]>gi|270003230|gb|EEZ99677.1| hypothetical protein TcasGA2_TC002434 [Tribolium castaneum]>gi|334261603|gb|AEG74042.1| cuticle protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26968 161 7.3e-10 Adult-specific cuticular protein ACP-22 OS=Tenebrio molitor GN=ACP22 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.64985 BP_3 130282.12 5883.74 1359 91082089 XP_967078.1 330 4.8e-28 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270007418|gb|EFA03866.1| hypothetical protein TcasGA2_TC013988 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 323 1.3e-28 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.64987 BP_3 1.00 1.27 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64988 BP_3 3353.60 163.73 1279 642920923 XP_008192617.1 861 1.2e-89 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q6W8P9 516 5.0e-51 Aldo-keto reductase family 1 member C23-like protein OS=Equus caballus GN=PGFS PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.64990 BP_3 202.60 15.74 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64991 BP_3 29.92 0.56 2863 642921498 XP_008192894.1 1550 3.4e-169 PREDICTED: uncharacterized protein LOC103312877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64993 BP_3 29.01 1.58 1179 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64994 BP_3 56.40 1.79 1808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64995 BP_3 24.51 2.40 785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64996 BP_3 54.27 1.68 1847 642917423 XP_008191192.1 1857 5.6e-205 PREDICTED: serologically defined colon cancer antigen 8 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B8JK76 284 5.8e-24 Serologically defined colon cancer antigen 8 homolog OS=Danio rerio GN=Sdccag8 PE=3 SV=2 PF02050//PF08702//PF02183//PF00038//PF05837//PF15964//PF04824 Flagellar FliJ protein//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Intermediate filament protein//Centromere protein H (CENP-H)//Centrosomal colon cancer autoantigen protein family//Conserved region of Rad21 / Rec8 like protein GO:0006935//GO:0051297//GO:0071973//GO:0030168//GO:0007165//GO:0051382//GO:0051258//GO:0006355 chemotaxis//centrosome organization//bacterial-type flagellum-dependent cell motility//platelet activation//signal transduction//kinetochore assembly//protein polymerization//regulation of transcription, DNA-templated GO:0030674//GO:0003774//GO:0005198//GO:0043565//GO:0005102//GO:0003700 protein binding, bridging//motor activity//structural molecule activity//sequence-specific DNA binding//receptor binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0000776//GO:0016020//GO:0005813//GO:0005882//GO:0009288//GO:0000228//GO:0005577 transcription factor complex//kinetochore//membrane//centrosome//intermediate filament//bacterial-type flagellum//nuclear chromosome//fibrinogen complex -- -- Cluster-8309.64998 BP_3 14.63 1.14 909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64999 BP_3 29.00 0.61 2590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65000 BP_3 89.03 5.53 1067 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02304 Scaffold protein B GO:0019069 viral capsid assembly -- -- GO:0046729 viral procapsid -- -- Cluster-8309.65001 BP_3 2.00 0.84 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65003 BP_3 4.00 0.53 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65004 BP_3 165.00 23.86 625 642913924 XP_008201216.1 183 2.4e-11 PREDICTED: serine protease easter-like [Tribolium castaneum]>gi|270001640|gb|EEZ98087.1| hypothetical protein TcasGA2_TC000498 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65005 BP_3 33.17 1.55 1320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65006 BP_3 126.56 6.12 1289 546686178 ERL95558.1 372 6.1e-33 hypothetical protein D910_12819 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65008 BP_3 2.00 0.33 588 270016897 EFA13343.1 158 1.8e-08 hypothetical protein TcasGA2_TC005298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65009 BP_3 2.01 0.46 504 478255481 ENN75698.1 255 8.8e-20 hypothetical protein YQE_07659, partial [Dendroctonus ponderosae]>gi|546676737|gb|ERL87693.1| hypothetical protein D910_05083 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 197 1.9e-14 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379//PF00978 Insect cuticle protein//RNA dependent RNA polymerase GO:0006351//GO:0006144 transcription, DNA-templated//purine nucleobase metabolic process GO:0003968//GO:0003723//GO:0042302 RNA-directed RNA polymerase activity//RNA binding//structural constituent of cuticle GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.65010 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65016 BP_3 6347.65 239.91 1567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.65017 BP_3 10.00 0.32 1818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65018 BP_3 10.60 0.76 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6502 BP_3 26.00 0.66 2186 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65020 BP_3 14446.03 677.15 1320 270003645 EFA00093.1 574 2.4e-56 hypothetical protein TcasGA2_TC002908 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80681 209 2.1e-15 Larval cuticle protein A1A OS=Tenebrio molitor PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65021 BP_3 5433.36 247.47 1350 270003645 EFA00093.1 675 4.7e-68 hypothetical protein TcasGA2_TC002908 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80681 209 2.1e-15 Larval cuticle protein A1A OS=Tenebrio molitor PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65022 BP_3 15.00 0.33 2511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65024 BP_3 8.00 0.76 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65025 BP_3 12.49 0.56 1359 642934936 XP_008195867.1 170 1.7e-09 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 130 3.28471e-59 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 139 2.8e-07 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF01749 Importin beta binding domain GO:0006606//GO:0015031 protein import into nucleus//protein transport GO:0008565 protein transporter activity GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.65027 BP_3 965.89 25.63 2108 642917922 XP_008200616.1 1570 1.2e-171 PREDICTED: probable cytochrome P450 303a1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q9V399 1053 4.5e-113 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.65028 BP_3 43.11 1.21 2009 270015871 EFA12319.1 1455 2.5e-158 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 Q62077 1087 4.8e-117 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Mus musculus GN=Plcg1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1264 Phospholipase C Cluster-8309.6503 BP_3 2.00 1.19 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65032 BP_3 59.00 44.85 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65037 BP_3 205.00 23.62 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65038 BP_3 4470.00 499.56 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65039 BP_3 3133.00 392.95 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65044 BP_3 40.08 0.57 3696 642934090 XP_008196737.1 2885 0.0e+00 PREDICTED: myelin transcription factor 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UL68 560 1.1e-55 Myelin transcription factor 1-like protein OS=Homo sapiens GN=MYT1L PE=2 SV=3 PF04111//PF10473//PF01105//PF01530//PF13851 Autophagy protein Apg6//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//emp24/gp25L/p24 family/GOLD//Zinc finger, C2HC type//Growth-arrest specific micro-tubule binding GO:0006355//GO:0006914//GO:0048870//GO:0006810 regulation of transcription, DNA-templated//autophagy//cell motility//transport GO:0003700//GO:0042803//GO:0008270//GO:0008134//GO:0045502 transcription factor activity, sequence-specific DNA binding//protein homodimerization activity//zinc ion binding//transcription factor binding//dynein binding GO:0005667//GO:0005634//GO:0016021//GO:0030286//GO:0031514 transcription factor complex//nucleus//integral component of membrane//dynein complex//motile cilium KOG3803 Transcription factor containing C2HC type Zn finger Cluster-8309.65046 BP_3 4168.32 74.54 2987 642939843 XP_008193782.1 2667 1.1e-298 PREDICTED: uncharacterized protein LOC657068 [Tribolium castaneum] 641658676 XM_001951259.3 168 5.49995e-80 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- P03952 447 1.2e-42 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.65048 BP_3 6.00 46.82 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65051 BP_3 50.00 0.99 2720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65052 BP_3 7075.00 459.42 1034 478260765 ENN80438.1 289 2.1e-23 hypothetical protein YQE_03142, partial [Dendroctonus ponderosae] 642925806 XM_964316.3 124 5.37189e-56 PREDICTED: Tribolium castaneum glycine-rich cell wall structural protein (LOC657888), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65053 BP_3 140.32 2.27 3271 642932128 XP_975308.3 2707 2.7e-303 PREDICTED: monocarboxylate transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36021 338 5.6e-30 Monocarboxylate transporter 8 OS=Homo sapiens GN=SLC16A2 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.65054 BP_3 79.59 0.70 5764 270012303 EFA08751.1 2048 1.2e-226 hypothetical protein TcasGA2_TC006428 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36021 276 1.5e-22 Monocarboxylate transporter 8 OS=Homo sapiens GN=SLC16A2 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.65056 BP_3 67.51 1.00 3554 546686178 ERL95558.1 291 4.2e-23 hypothetical protein D910_12819 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65057 BP_3 45.38 0.75 3226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65059 BP_3 194.41 5.16 2107 546677765 ERL88544.1 255 3.7e-19 hypothetical protein D910_05929 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V7U0 252 3.4e-20 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379//PF03009 Insect cuticle protein//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:0008081//GO:0042302 phosphoric diester hydrolase activity//structural constituent of cuticle -- -- -- -- Cluster-8309.6506 BP_3 11.09 0.32 1955 189239542 XP_001816493.1 287 6.7e-23 PREDICTED: uncharacterized protein LOC100141605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65060 BP_3 17129.73 1088.86 1050 270004185 EFA00633.1 406 5.7e-37 hypothetical protein TcasGA2_TC003509 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 228 1.0e-17 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65062 BP_3 54.46 0.48 5729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.65063 BP_3 68.68 0.61 5719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.65066 BP_3 491.80 25.45 1223 478253664 ENN73966.1 474 8.6e-45 hypothetical protein YQE_09422, partial [Dendroctonus ponderosae]>gi|546684439|gb|ERL94082.1| hypothetical protein D910_11364 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65067 BP_3 1.00 2.46 288 642926348 XP_008194888.1 329 1.3e-28 PREDICTED: fructose-bisphosphate aldolase isoform X1 [Tribolium castaneum] 221048060 FJ438514.1 60 5.17854e-21 Epinephelus coioides fructose-bisphosphate aldolase mRNA, partial cds K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P07764 277 5.8e-24 Fructose-bisphosphate aldolase OS=Drosophila melanogaster GN=Ald PE=1 SV=5 PF00274 Fructose-bisphosphate aldolase class-I GO:0006096//GO:0006098//GO:0006020//GO:0006094//GO:0015976//GO:0006013//GO:0006000 glycolytic process//pentose-phosphate shunt//inositol metabolic process//gluconeogenesis//carbon utilization//mannose metabolic process//fructose metabolic process GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8309.65069 BP_3 14.00 0.70 1254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65071 BP_3 145.00 3.57 2251 189235901 XP_001808773.1 661 3.3e-66 PREDICTED: uncharacterized protein LOC100142021 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65078 BP_3 1.00 0.40 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65079 BP_3 2.00 0.93 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65080 BP_3 4.00 0.57 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65081 BP_3 820.00 9.08 4643 642916264 XP_008190954.1 1114 2.0e-118 PREDICTED: titin [Tribolium castaneum]>gi|270003681|gb|EFA00129.1| hypothetical protein TcasGA2_TC002945 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001//PF00558 7 transmembrane receptor (rhodopsin family)//Vpu protein GO:0007186//GO:0006812//GO:0032801//GO:0019076 G-protein coupled receptor signaling pathway//cation transport//receptor catabolic process//viral release from host cell GO:0004930//GO:0005261 G-protein coupled receptor activity//cation channel activity GO:0033644//GO:0016021 host cell membrane//integral component of membrane -- -- Cluster-8309.65083 BP_3 2.00 0.62 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65090 BP_3 3.24 0.52 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65091 BP_3 3.00 0.57 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08273 Zinc-binding domain of primase-helicase GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0008270//GO:0004386//GO:0003896 zinc ion binding//helicase activity//DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.65095 BP_3 10.00 1.02 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65097 BP_3 272.93 18.44 1005 546681140 ERL91290.1 1012 2.9e-107 hypothetical protein D910_08623 [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 564 1.1e-56 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.65098 BP_3 7.00 0.44 1056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.651 BP_3 2.01 0.94 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6510 BP_3 3.00 0.40 653 397516651 XP_003828537.1 1149 2.5e-123 PREDICTED: elongation factor 1-gamma [Pan paniscus] 649152470 KJ905736.1 653 0 Synthetic construct Homo sapiens clone ccsbBroadEn_15406 EEF1G gene, encodes complete protein K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 P26641 1149 1.0e-124 Elongation factor 1-gamma OS=Homo sapiens GN=EEF1G PE=1 SV=3 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG0867 Glutathione S-transferase Cluster-8309.65100 BP_3 29.92 0.33 4644 642939843 XP_008193782.1 1175 1.7e-125 PREDICTED: uncharacterized protein LOC657068 [Tribolium castaneum] 641658676 XM_001951259.3 128 1.47836e-57 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- P03952 372 9.1e-34 Plasma kallikrein OS=Homo sapiens GN=KLKB1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.65103 BP_3 1523.48 18.73 4213 270010992 EFA07440.1 1052 2.8e-111 hormone receptor in 46-like protein [Tribolium castaneum] 642929404 XM_969468.3 229 9.58386e-114 PREDICTED: Tribolium castaneum probable nuclear hormone receptor HR3 (LOC663422), transcript variant X1, mRNA K14033 NR1F4 nuclear receptor subfamily 1 group F member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14033 P49868 753 5.4e-78 Probable nuclear hormone receptor HR3 OS=Galleria mellonella GN=HR3 PE=2 SV=1 PF00105//PF07998 Zinc finger, C4 type (two domains)//Peptidase family M54 GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.65105 BP_3 1718.12 76.59 1373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65108 BP_3 9.00 0.79 841 333441020 AEF32709.1 550 9.1e-54 prostaglandin D synthase [Eriocheir sinensis] 333103083 JF715388.1 164 2.51839e-78 Scylla paramamosain clone SP04 microsatellite sequence -- -- -- -- O60760 320 1.8e-28 Hematopoietic prostaglandin D synthase OS=Homo sapiens GN=HPGDS PE=1 SV=3 PF13409//PF02798//PF15761//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Immortalisation up-regulated protein//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.65109 BP_3 2.00 1.39 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65112 BP_3 375.00 15.51 1457 642917914 XP_008191380.1 1052 9.8e-112 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q83140 507 6.3e-50 Ecdysteroid UDP-glucosyltransferase OS=Mamestra brassicae nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.65114 BP_3 14.46 0.36 2209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65115 BP_3 3.00 2.63 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65116 BP_3 18.00 2.92 589 270008852 EFA05300.1 382 1.9e-34 hypothetical protein TcasGA2_TC015457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88703 182 1.2e-12 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Mus musculus GN=Hcn2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain Cluster-8309.65122 BP_3 22.04 0.74 1727 815923656 XP_012246575.1 1047 4.4e-111 PREDICTED: DNA (cytosine-5)-methyltransferase 1-like isoform X2 [Bombus impatiens] -- -- -- -- -- K00558 DNMT1, dcm DNA (cytosine-5)-methyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00558 Q27746 986 2.1e-105 DNA (cytosine-5)-methyltransferase PliMCI OS=Paracentrotus lividus GN=DNMT PE=2 SV=1 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.65125 BP_3 4.00 2.43 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65129 BP_3 8.00 1.06 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65130 BP_3 1.00 0.32 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65132 BP_3 11.00 0.85 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65133 BP_3 19.86 0.55 2044 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65139 BP_3 1608.00 46.24 1968 642921715 XP_008194803.1 324 3.4e-27 PREDICTED: uncharacterized protein LOC100142057 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02535//PF01080//PF02724//PF09507//PF00257 ZIP Zinc transporter//Presenilin//CDC45-like protein//DNA polymerase subunit Cdc27//Dehydrin GO:0030001//GO:0006950//GO:0055085//GO:0006270//GO:0006260//GO:0009415 metal ion transport//response to stress//transmembrane transport//DNA replication initiation//DNA replication//response to water GO:0004190//GO:0046873 aspartic-type endopeptidase activity//metal ion transmembrane transporter activity GO:0005634//GO:0016021//GO:0016020 nucleus//integral component of membrane//membrane -- -- Cluster-8309.65140 BP_3 30.00 3.99 654 642922031 XP_008192992.1 228 1.5e-16 PREDICTED: cuticle protein 7 [Tribolium castaneum]>gi|270007264|gb|EFA03712.1| hypothetical protein TcasGA2_TC013817 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 183 1.0e-12 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65141 BP_3 18.00 25.71 312 642922031 XP_008192992.1 223 2.8e-16 PREDICTED: cuticle protein 7 [Tribolium castaneum]>gi|270007264|gb|EFA03712.1| hypothetical protein TcasGA2_TC013817 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 166 4.7e-11 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65143 BP_3 3.00 1.49 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65146 BP_3 10.00 0.38 1550 312082450 XP_003143449.1 535 9.2e-52 excitatory amino acid transporter [Loa loa]>gi|307761384|gb|EFO20618.1| excitatory amino acid transporter [Loa loa] 697085165 XM_009657201.1 1437 0 Verticillium dahliae VdLs.17 excitatory amino acid transporter 2 partial mRNA K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 P43004 460 1.9e-44 Excitatory amino acid transporter 2 OS=Homo sapiens GN=SLC1A2 PE=1 SV=2 PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane -- -- Cluster-8309.65148 BP_3 35.00 0.67 2801 310743896 BAJ23879.1 3995 0.0e+00 glycogen phosphorylase [Marsupenaeus japonicus] 310743895 AB596876.1 950 0 Marsupenaeus japonicus MjGP mRNA for glycogen phosphorylase, complete cds K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 Q9XTL9 3424 0.0e+00 Glycogen phosphorylase OS=Drosophila melanogaster GN=GlyP PE=2 SV=2 PF00276//PF00343 Ribosomal protein L23//Carbohydrate phosphorylase GO:0006412//GO:0005975//GO:0042254 translation//carbohydrate metabolic process//ribosome biogenesis GO:0008184//GO:0003735 glycogen phosphorylase activity//structural constituent of ribosome GO:0005840 ribosome KOG2099 Glycogen phosphorylase Cluster-8309.6515 BP_3 18.00 0.34 2848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65153 BP_3 7.00 0.35 1266 641764353 XP_005299093.2 1033 1.4e-109 PREDICTED: oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [Chrysemys picta bellii] 697066440 XM_009650112.1 1254 0 Verticillium dahliae VdLs.17 coproporphyrinogen III oxidase partial mRNA K00228 CPOX, hemF coproporphyrinogen III oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00228 P11353 1013 1.2e-108 Oxygen-dependent coproporphyrinogen-III oxidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM13 PE=1 SV=2 PF01218 Coproporphyrinogen III oxidase GO:0006779//GO:0055114//GO:0015994 porphyrin-containing compound biosynthetic process//oxidation-reduction process//chlorophyll metabolic process GO:0004109 coproporphyrinogen oxidase activity -- -- KOG1518 Coproporphyrinogen III oxidase CPO/HEM13 Cluster-8309.65154 BP_3 2.00 0.47 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04848 Poxvirus A22 protein GO:0006281//GO:0006310 DNA repair//DNA recombination GO:0000287//GO:0000400//GO:0016788 magnesium ion binding//four-way junction DNA binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.65155 BP_3 45.00 9.10 530 546677149 ERL88046.1 224 3.6e-16 hypothetical protein D910_05435, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF07382 Chitin binding Peritrophin-A domain//Histone H1-like nucleoprotein HC2 GO:0030261//GO:0006030 chromosome condensation//chitin metabolic process GO:0008061//GO:0003677 chitin binding//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.65157 BP_3 14.00 0.58 1464 657189747 AID47196.1 1318 1.4e-142 trypsin [Macrophthalmus japonicus] -- -- -- -- -- -- -- -- -- P83748 356 2.1e-32 Serine protease 30 OS=Rattus norvegicus GN=Prss30 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.65159 BP_3 2.37 0.34 625 642914176 XP_008201576.1 721 1.0e-73 PREDICTED: uncharacterized protein LOC103315219 [Tribolium castaneum]>gi|270002173|gb|EEZ98620.1| hypothetical protein TcasGA2_TC001143 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.65165 BP_3 73.00 4.89 1011 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65166 BP_3 29.24 0.62 2552 642933873 XP_008197547.1 961 6.1e-101 PREDICTED: lipase member I-like [Tribolium castaneum] -- -- -- -- -- K13618 PLA1A phospholipase A1 member A http://www.genome.jp/dbget-bin/www_bget?ko:K13618 P27656 316 1.6e-27 Hepatic triacylglycerol lipase OS=Mus musculus GN=Lipc PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65168 BP_3 25.00 2.26 825 642924014 XP_008193969.1 387 7.1e-35 PREDICTED: G2/mitotic-specific cyclin-B [Tribolium castaneum]>gi|270007806|gb|EFA04254.1| hypothetical protein TcasGA2_TC014544 [Tribolium castaneum] -- -- -- -- -- K00774 PARP16 poly http://www.genome.jp/dbget-bin/www_bget?ko:K00774 Q9DG96 263 7.0e-22 G2/mitotic-specific cyclin-B2 OS=Oryzias luzonensis GN=ccnb2 PE=2 SV=1 PF02180 Bcl-2 homology region 4 GO:0042981//GO:0044763 regulation of apoptotic process//single-organism cellular process -- -- -- -- KOG0653 Cyclin B and related kinase-activating proteins Cluster-8309.65169 BP_3 20.50 0.74 1625 546680046 ERL90401.1 532 2.2e-51 hypothetical protein D910_07750 [Dendroctonus ponderosae] -- -- -- -- -- K05868 CCNB cyclin B http://www.genome.jp/dbget-bin/www_bget?ko:K05868 P13952 395 6.8e-37 G2/mitotic-specific cyclin-B OS=Spisula solidissima PE=2 SV=1 PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus KOG0653 Cyclin B and related kinase-activating proteins Cluster-8309.65170 BP_3 20.50 0.74 1625 478250326 ENN70823.1 364 6.5e-32 hypothetical protein YQE_12488, partial [Dendroctonus ponderosae] -- -- -- -- -- K05868 CCNB cyclin B http://www.genome.jp/dbget-bin/www_bget?ko:K05868 P24862 274 7.3e-23 G2/mitotic-specific cyclin-B OS=Patella vulgata PE=2 SV=1 PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus KOG0653 Cyclin B and related kinase-activating proteins Cluster-8309.65171 BP_3 87.33 2.95 1719 270006200 EFA02648.1 1215 1.4e-130 hypothetical protein TcasGA2_TC008369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65174 BP_3 21.00 1.46 985 607355961 EZA50509.1 391 2.9e-35 hypothetical protein X777_10702 [Cerapachys biroi] 462330447 APGK01040014.1 223 4.72619e-111 Dendroctonus ponderosae Seq01040024, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65175 BP_3 160.66 6.09 1563 642939900 XP_008200249.1 1278 6.5e-138 PREDICTED: proton-coupled amino acid transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUX1 169 1.1e-10 Sodium-coupled neutral amino acid transporter 5 OS=Homo sapiens GN=SLC38A5 PE=1 SV=1 PF07034 Origin recognition complex (ORC) subunit 3 N-terminus GO:0006260 DNA replication GO:0003677 DNA binding GO:0005664 nuclear origin of replication recognition complex KOG1303 Amino acid transporters Cluster-8309.65177 BP_3 50.00 0.89 3010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65178 BP_3 3.00 0.80 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039//PF04834 Mitochondrial proteolipid//Early E3 14.5 kDa protein GO:0009966 regulation of signal transduction -- -- GO:0005739//GO:0016021 mitochondrion//integral component of membrane -- -- Cluster-8309.65187 BP_3 8.83 0.45 1238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65189 BP_3 19.00 3.50 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6519 BP_3 7.00 0.60 852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65192 BP_3 193.40 8.85 1345 642920923 XP_008192617.1 828 8.5e-86 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q6W8P9 488 9.3e-48 Aldo-keto reductase family 1 member C23-like protein OS=Equus caballus GN=PGFS PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.65193 BP_3 40.00 10.80 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65195 BP_3 4.46 0.35 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65197 BP_3 11.45 2.17 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65202 BP_3 84.48 1.95 2385 357616848 EHJ70441.1 1434 8.1e-156 serine protease [Danaus plexippus] 642930385 XM_001813893.2 99 9.96511e-42 PREDICTED: Tribolium castaneum serine proteinase stubble (LOC662802), mRNA -- -- -- -- Q05319 650 2.7e-66 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089//PF00548 Trypsin//3C cysteine protease (picornain 3C) GO:0006508 proteolysis GO:0004197//GO:0004252 cysteine-type endopeptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.65203 BP_3 914.68 12.87 3716 642933871 XP_974162.3 1216 2.4e-130 PREDICTED: uncharacterized protein LOC663002 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q8VBX1 357 4.0e-32 Endothelial lipase OS=Rattus norvegicus GN=Lipg PE=2 SV=2 PF01674//PF08476 Lipase (class 2)//Viral D10 N-terminal -- -- GO:0016787//GO:0016791 hydrolase activity//phosphatase activity -- -- -- -- Cluster-8309.65205 BP_3 6.00 0.33 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65206 BP_3 28.50 0.44 3425 546686178 ERL95558.1 373 1.2e-32 hypothetical protein D910_12819 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65208 BP_3 72.18 0.67 5521 642915681 XP_008190757.1 2767 5.2e-310 PREDICTED: kin of IRRE-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RW7 196 2.8e-13 Hemicentin-1 OS=Homo sapiens GN=HMCN1 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.65209 BP_3 63.28 1.49 2334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6521 BP_3 30.01 0.77 2168 688549951 XP_009298913.1 937 3.1e-98 PREDICTED: zinc finger protein 721-like, partial [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 918 2.1e-97 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF13465//PF00096//PF13912//PF02892//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.65211 BP_3 53.00 5.17 786 328899797 AEB54649.1 953 1.6e-100 ribosomal protein S6 [Procambarus clarkii] 194763267 XM_001963719.1 210 6.29808e-104 Drosophila ananassae GF21093 (Dana\GF21093), mRNA K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 Q2PQM1 847 1.3e-89 40S ribosomal protein S6 OS=Glossina morsitans morsitans GN=RpS6 PE=2 SV=1 PF01092 Ribosomal protein S6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1646 40S ribosomal protein S6 Cluster-8309.65213 BP_3 319.00 12.60 1512 270005241 EFA01689.1 1607 4.5e-176 hypothetical protein TcasGA2_TC007264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NR61 463 8.3e-45 Delta-like protein 4 OS=Homo sapiens GN=DLL4 PE=1 SV=1 PF00008//PF01414 EGF-like domain//Delta serrate ligand GO:0007154 cell communication GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.65216 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65217 BP_3 40.01 2.22 1160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03857 Colicin immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.65218 BP_3 10036.54 269.31 2088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65220 BP_3 14.78 0.33 2468 642914878 XP_008190428.1 2211 6.7e-246 PREDICTED: unconventional myosin-Ia [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 O43795 1155 7.8e-125 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF00612//PF06414//PF02367//PF00158//PF00063//PF00437//PF11803 IQ calmodulin-binding motif//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Sigma-54 interaction domain//Myosin head (motor domain)//Type II/IV secretion system protein//UDP-glucuronate decarboxylase N-terminal GO:0002949//GO:0006355//GO:0005982//GO:0005985//GO:0009117//GO:0006810 tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//starch metabolic process//sucrose metabolic process//nucleotide metabolic process//transport GO:0003774//GO:0016301//GO:0005524//GO:0048040//GO:0008134//GO:0005515 motor activity//kinase activity//ATP binding//UDP-glucuronate decarboxylase activity//transcription factor binding//protein binding GO:0016459//GO:0005667 myosin complex//transcription factor complex KOG0164 Myosin class I heavy chain Cluster-8309.65224 BP_3 1962.00 50.51 2164 270006282 EFA02730.1 385 3.2e-34 hypothetical protein TcasGA2_TC008455 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65225 BP_3 2.00 3.53 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65226 BP_3 7.00 0.36 1241 675368932 KFM61834.1 285 7.2e-23 RNA-directed DNA polymerase from mobile element jockey, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q95SX7 158 1.6e-09 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65227 BP_3 33.43 0.83 2228 607357734 EZA52175.1 161 3.1e-08 hypothetical protein X777_08688, partial [Cerapachys biroi] 462331162 APGK01039783.1 105 4.29607e-45 Dendroctonus ponderosae Seq01039793, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6523 BP_3 13.45 1.13 864 642920673 XP_008192516.1 176 2.2e-10 PREDICTED: troponin I 2 isoform X8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01456 140 1.3e-07 Ovarian abundant message protein OS=Ascaris suum GN=OAM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65231 BP_3 18.00 6.43 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65236 BP_3 6.00 5.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65237 BP_3 16.00 1.50 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65240 BP_3 13.48 0.46 1698 189239958 XP_973407.2 1245 4.8e-134 PREDICTED: carboxypeptidase B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04069 758 5.8e-79 Carboxypeptidase B OS=Astacus astacus PE=1 SV=1 PF02244//PF04952//PF00246 Carboxypeptidase activation peptide//Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004181//GO:0004180//GO:0008270//GO:0016788 metallocarboxypeptidase activity//carboxypeptidase activity//zinc ion binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.65241 BP_3 45.00 0.74 3213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65244 BP_3 82.00 28.85 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65245 BP_3 418.69 10.37 2238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65249 BP_3 59.82 1.05 3043 91087141 XP_975282.1 3305 0.0e+00 PREDICTED: inactive dipeptidyl peptidase 10 [Tribolium castaneum]>gi|270009589|gb|EFA06037.1| hypothetical protein TcasGA2_TC008867 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N608 1093 1.5e-117 Inactive dipeptidyl peptidase 10 OS=Homo sapiens GN=DPP10 PE=1 SV=2 PF03721//PF00326//PF00930//PF02129//PF05652 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Prolyl oligopeptidase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region//X-Pro dipeptidyl-peptidase (S15 family)//Scavenger mRNA decapping enzyme (DcpS) N-terminal GO:0055114//GO:0000290//GO:0006508 oxidation-reduction process//deadenylation-dependent decapping of nuclear-transcribed mRNA//proteolysis GO:0008236//GO:0016616//GO:0051287//GO:0016787 serine-type peptidase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//hydrolase activity GO:0016020 membrane KOG2100 Dipeptidyl aminopeptidase Cluster-8309.6525 BP_3 41.00 0.70 3099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65251 BP_3 2.00 0.45 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65257 BP_3 4.00 0.95 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65260 BP_3 3.00 1.01 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65261 BP_3 1.00 0.41 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65262 BP_3 52.25 0.39 6675 546678803 ERL89348.1 899 2.5e-93 hypothetical protein D910_06719 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414//PF08845//PF00515//PF13181//PF03842 TPR repeat//Toxin SymE, type I toxin-antitoxin system//Tetratricopeptide repeat//Tetratricopeptide repeat//Silicon transporter GO:0016070//GO:0015708 RNA metabolic process//silicate transport GO:0005515//GO:0016788//GO:0003723 protein binding//hydrolase activity, acting on ester bonds//RNA binding GO:0005737 cytoplasm -- -- Cluster-8309.65265 BP_3 407.11 9.56 2344 189237315 XP_972608.2 2436 5.2e-272 PREDICTED: protocadherin Fat 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9R0M0 378 9.2e-35 Cadherin EGF LAG seven-pass G-type receptor 2 OS=Mus musculus GN=Celsr2 PE=1 SV=2 PF00028//PF12199 Cadherin domain//Extracellular fibrinogen binding protein C terminal GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0001848 calcium ion binding//complement binding GO:0005615//GO:0016020 extracellular space//membrane KOG3594 FOG: Cadherin repeats Cluster-8309.65271 BP_3 338.00 18.20 1187 478257250 ENN77413.1 695 2.0e-70 hypothetical protein YQE_06238, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VBV3 142 1.1e-07 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65276 BP_3 18.72 0.65 1683 478252210 ENN72638.1 931 1.2e-97 hypothetical protein YQE_10736, partial [Dendroctonus ponderosae] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 Q9VPH2 563 2.3e-56 DNA primase large subunit OS=Drosophila melanogaster GN=DNApol-alpha60 PE=1 SV=2 PF04104//PF00542 Eukaryotic and archaeal DNA primase, large subunit//Ribosomal protein L7/L12 C-terminal domain GO:0042254//GO:0006269//GO:0006412//GO:0006351 ribosome biogenesis//DNA replication, synthesis of RNA primer//translation//transcription, DNA-templated GO:0003735//GO:0003896 structural constituent of ribosome//DNA primase activity GO:0005730//GO:0005840//GO:0005657 nucleolus//ribosome//replication fork KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.6528 BP_3 1.00 0.36 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65280 BP_3 137.13 2.49 2941 -- -- -- -- -- 642915649 XM_967018.2 68 2.10489e-24 PREDICTED: Tribolium castaneum tyrosine-protein kinase-like otk (LOC660815), mRNA -- -- -- -- -- -- -- -- PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0046500//GO:0006464//GO:0006479 S-adenosylmethionine metabolic process//cellular protein modification process//protein methylation GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity -- -- -- -- Cluster-8309.65283 BP_3 3.00 0.36 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65284 BP_3 6.92 0.41 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15894 Inhibitor of glucose uptake transporter SgrT GO:0046325 negative regulation of glucose import -- -- -- -- -- -- Cluster-8309.65287 BP_3 4.81 0.34 980 642911411 XP_008199411.1 220 2.0e-15 PREDICTED: lachesin-like isoform X1 [Tribolium castaneum] 642911414 XM_008201191.1 46 1.16407e-12 PREDICTED: Tribolium castaneum lachesin-like (LOC661289), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65291 BP_3 3.00 0.64 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6530 BP_3 17.08 0.65 1556 642939568 XP_001808071.2 909 4.0e-95 PREDICTED: uncharacterized protein LOC100141755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03137 Organic Anion Transporter Polypeptide (OATP) family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.65300 BP_3 54.00 5.86 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65301 BP_3 527.27 7.19 3825 642916323 XP_008190973.1 324 6.7e-27 PREDICTED: cuticle protein 19-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 212 2.7e-15 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65302 BP_3 25.00 8.38 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65303 BP_3 4.00 0.98 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65305 BP_3 13.68 0.60 1387 189234553 XP_973928.2 509 8.5e-49 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V9A8 291 6.7e-25 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6531 BP_3 2.00 1.56 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65310 BP_3 7.00 1.09 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65314 BP_3 9.00 0.60 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65316 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65320 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65321 BP_3 37.51 1.81 1290 270001464 EEZ97911.1 986 3.9e-104 hypothetical protein TcasGA2_TC000296 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PHZ8 604 3.2e-61 Kv channel-interacting protein 4 OS=Mus musculus GN=Kcnip4 PE=1 SV=1 PF13202//PF00036//PF04434//PF12763//PF13499//PF10591//PF13405//PF13833 EF hand//EF hand//SWIM zinc finger//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0005515//GO:0005509//GO:0008270 protein binding//calcium ion binding//zinc ion binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.65326 BP_3 2.00 87.44 209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6533 BP_3 33.74 0.72 2560 189238160 XP_001814766.1 394 3.4e-35 PREDICTED: zinc finger SWIM domain-containing protein 7 isoform X1 [Tribolium castaneum]>gi|270008721|gb|EFA05169.1| hypothetical protein TcasGA2_TC015298 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 Q3ZBL5 190 6.4e-13 Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus GN=PTRH2 PE=2 SV=1 PF01981//PF09243//PF04434 Peptidyl-tRNA hydrolase PTH2//Mitochondrial small ribosomal subunit Rsm22//SWIM zinc finger GO:0006412 translation GO:0004045//GO:0008168//GO:0008270 aminoacyl-tRNA hydrolase activity//methyltransferase activity//zinc ion binding -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.65330 BP_3 4.00 0.52 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65331 BP_3 74.17 0.87 4385 642913653 XP_008201105.1 591 8.4e-58 PREDICTED: mucin-2-like [Tribolium castaneum]>gi|270002054|gb|EEZ98501.1| hypothetical protein TcasGA2_TC001002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02723//PF05356 Non-structural protein NS3/Small envelope protein E//Phage Coat protein B -- -- -- -- GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-8309.65332 BP_3 6.00 1.00 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65338 BP_3 23.29 2.47 746 91091098 XP_968555.1 250 5.0e-19 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270014078|gb|EFA10526.1| hypothetical protein TcasGA2_TC012778 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006200 obsolete ATP catabolic process GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- -- -- Cluster-8309.65339 BP_3 102.00 6.88 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6534 BP_3 4.51 0.68 613 642918175 XP_008191397.1 364 2.5e-32 PREDICTED: glycosyltransferase-like domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXN0 305 7.0e-27 Glycosyltransferase-like domain-containing protein 1-like OS=Drosophila melanogaster GN=CG15914 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65342 BP_3 74.59 2.14 1974 646723447 KDR24044.1 1510 1.0e-164 hypothetical protein L798_09379, partial [Zootermopsis nevadensis] 755853840 XM_011297515.1 82 2.31868e-32 PREDICTED: Musca domestica uncharacterized LOC101899955 (LOC101899955), mRNA -- -- -- -- Q6X0I2 130 4.4e-06 Vitellogenin receptor OS=Solenopsis invicta GN=VgR PE=2 SV=1 PF00057//PF01607//PF01522//PF05026//PF05656 Low-density lipoprotein receptor domain class A//Chitin binding Peritrophin-A domain//Polysaccharide deacetylase//Dcp2, box A domain//Protein of unknown function (DUF805) GO:0006030//GO:0005975//GO:0006807 chitin metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0030145//GO:0005515//GO:0016787//GO:0003723//GO:0016810//GO:0008061 manganese ion binding//protein binding//hydrolase activity//RNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.65343 BP_3 2.82 0.35 679 646723447 KDR24044.1 723 6.4e-74 hypothetical protein L798_09379, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65345 BP_3 30.00 0.42 3703 91091632 XP_970225.1 1260 1.9e-135 PREDICTED: neuropeptide FF receptor 2 [Tribolium castaneum]>gi|270001267|gb|EEZ97714.1| hypothetical protein TcasGA2_TC011156, partial [Tribolium castaneum]>gi|402232706|tpg|DAA35194.1| TPA_inf: SIFamide receptor, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5X5 307 2.5e-26 Neuropeptide FF receptor 2 OS=Homo sapiens GN=NPFFR2 PE=1 SV=2 PF12822//PF03600//PF00001 Protein of unknown function (DUF3816)//Citrate transporter//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0055085//GO:0007187//GO:0006810//GO:0007268 G-protein coupled receptor signaling pathway//transmembrane transport//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//transport//synaptic transmission GO:0004930//GO:0005215//GO:0004983 G-protein coupled receptor activity//transporter activity//neuropeptide Y receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.65346 BP_3 11.00 0.71 1043 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65351 BP_3 37.28 0.94 2196 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00220//PF14144 Neurohypophysial hormones, N-terminal Domain//Seed dormancy control GO:0006351//GO:0007218 transcription, DNA-templated//neuropeptide signaling pathway GO:0005185//GO:0043565 neurohypophyseal hormone activity//sequence-specific DNA binding GO:0005576 extracellular region -- -- Cluster-8309.65355 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65356 BP_3 10.00 1.62 589 297287755 XP_001106448.2 212 1.0e-14 PREDICTED: 60S ribosomal protein L36-like [Macaca mulatta] 697084665 XM_009656994.1 580 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 Q9HFR7 337 1.3e-30 60S ribosomal protein L36 OS=Trichoderma hamatum GN=rpl36 PE=3 SV=1 PF01158 Ribosomal protein L36e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-8309.65359 BP_3 6.88 0.43 1062 780122407 XP_011678094.1 486 3.0e-46 PREDICTED: RNA-directed DNA polymerase from mobile element jockey-like [Strongylocentrotus purpuratus] 218156961 FJ439606.1 188 1.46122e-91 Scylla serrata clone SSF6 microsatellite sequence -- -- -- -- Q9NBX4 184 1.3e-12 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65361 BP_3 38.97 1.37 1660 607353521 EZA48267.1 198 1.2e-12 hypothetical protein X777_14099 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65369 BP_3 15.00 1.21 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6537 BP_3 19.00 0.42 2454 751231572 XP_011169356.1 1074 4.6e-114 PREDICTED: uncharacterized protein LOC105202492 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225//PF06308 DDE superfamily endonuclease//helix-turn-helix, Psq domain//23S rRNA methylase leader peptide (ErmC) GO:0046677 response to antibiotic GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.65371 BP_3 15.45 0.82 1200 861599125 KMQ83546.1 679 1.4e-68 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65372 BP_3 12.00 0.91 927 861599125 KMQ83546.1 255 1.6e-19 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01047//PF09339//PF01498 MarR family//IclR helix-turn-helix domain//Transposase GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.65374 BP_3 3.00 1.40 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.65377 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6538 BP_3 6828.64 360.39 1205 91087749 XP_974872.1 354 7.0e-31 PREDICTED: probable H/ACA ribonucleoprotein complex subunit 1 [Tribolium castaneum]>gi|270010737|gb|EFA07185.1| hypothetical protein TcasGA2_TC010191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65380 BP_3 10032.99 183.12 3069 642935173 XP_008199677.1 206 2.6e-13 PREDICTED: elongation of very long chain fatty acids protein 7 [Tribolium castaneum]>gi|270014194|gb|EFA10642.1| hypothetical protein TcasGA2_TC016279 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JNC4 156 6.7e-09 Elongation of very long chain fatty acids protein 7 OS=Bos taurus GN=ELOVL7 PE=2 SV=1 PF01151//PF14750 GNS1/SUR4 family//Integrator complex subunit 2 -- -- -- -- GO:0032039//GO:0016021 integrator complex//integral component of membrane -- -- Cluster-8309.65388 BP_3 1.00 2.95 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65390 BP_3 110.00 1.56 3695 270001277 EEZ97724.1 1680 3.7e-184 oo18 RNA-binding protein [Tribolium castaneum] -- -- -- -- -- K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 Q52KN7 1075 2.2e-115 Cytoplasmic polyadenylation element-binding protein 1-B OS=Xenopus laevis GN=cpeb1-b PE=2 SV=1 PF00643//PF00076//PF16367 B-box zinc finger//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular KOG0129 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.65391 BP_3 5.87 0.43 944 270005484 EFA01932.1 188 9.7e-12 hypothetical protein TcasGA2_TC007546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65394 BP_3 5.00 0.80 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65396 BP_3 2.00 7.62 272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65397 BP_3 12.05 0.34 2000 642915632 XP_008190690.1 736 5.9e-75 PREDICTED: orthodenticle-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K09326 OTX1 homeobox protein OTX1 http://www.genome.jp/dbget-bin/www_bget?ko:K09326 P22810 375 1.8e-34 Homeotic protein ocelliless OS=Drosophila melanogaster GN=oc PE=2 SV=2 PF00046//PF00424 Homeobox domain//REV protein (anti-repression trans-activator protein) GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0042025 transcription factor complex//host cell nucleus KOG2251 Homeobox transcription factor Cluster-8309.65400 BP_3 3.72 0.59 593 642931369 XP_008196550.1 597 2.3e-59 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931368 XM_008198328.1 132 1.07242e-60 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X6, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 432 1.3e-41 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0245 Kinesin-like protein Cluster-8309.65403 BP_3 3.00 0.88 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65404 BP_3 17.00 4.83 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65410 BP_3 12.10 0.33 2069 270006871 EFA03319.1 296 6.4e-24 hypothetical protein TcasGA2_TC013262 [Tribolium castaneum] 462314888 APGK01045625.1 35 3.25964e-06 Dendroctonus ponderosae Seq01045635, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65414 BP_3 154.31 3.09 2699 189238523 XP_972430.2 2738 5.7e-307 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 1125 2.6e-121 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01134//PF05199//PF03728//PF01266//PF05834//PF00732//PF02254//PF07992 Glucose inhibited division protein A//GMC oxidoreductase//Viral DNA-binding protein, zinc binding domain//FAD dependent oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase GO:0016117//GO:0006260//GO:0008033//GO:0055114//GO:0006813 carotenoid biosynthetic process//DNA replication//tRNA processing//oxidation-reduction process//potassium ion transport GO:0050660//GO:0008270//GO:0003677//GO:0016614//GO:0016705//GO:0016491 flavin adenine dinucleotide binding//zinc ion binding//DNA binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- -- -- Cluster-8309.65415 BP_3 32.21 0.63 2754 546682667 ERL92579.1 1695 5.1e-186 hypothetical protein D910_09892 [Dendroctonus ponderosae] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 641 3.5e-65 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF01134//PF01266//PF05834//PF00732//PF03728//PF02254//PF07992 GMC oxidoreductase//Glucose inhibited division protein A//FAD dependent oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Viral DNA-binding protein, zinc binding domain//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0008033//GO:0016117//GO:0006260//GO:0006813 oxidation-reduction process//tRNA processing//carotenoid biosynthetic process//DNA replication//potassium ion transport GO:0008270//GO:0050660//GO:0016491//GO:0016614//GO:0016705//GO:0003677 zinc ion binding//flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//DNA binding -- -- -- -- Cluster-8309.65416 BP_3 20.92 0.47 2427 189238523 XP_972430.2 1689 2.2e-185 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 749 9.1e-78 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF02254//PF07992//PF05199//PF01134//PF05834//PF00732//PF01266//PF03728 TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//Glucose inhibited division protein A//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase//Viral DNA-binding protein, zinc binding domain GO:0006813//GO:0006260//GO:0016117//GO:0055114//GO:0008033 potassium ion transport//DNA replication//carotenoid biosynthetic process//oxidation-reduction process//tRNA processing GO:0016705//GO:0016614//GO:0003677//GO:0016491//GO:0008270//GO:0050660 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//DNA binding//oxidoreductase activity//zinc ion binding//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.65417 BP_3 156.55 3.32 2565 189238523 XP_972430.2 2738 5.4e-307 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 1125 2.4e-121 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF05834//PF00732//PF07992//PF05199//PF02254//PF01134 FAD dependent oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//TrkA-N domain//Glucose inhibited division protein A GO:0016117//GO:0008033//GO:0055114//GO:0006813 carotenoid biosynthetic process//tRNA processing//oxidation-reduction process//potassium ion transport GO:0050660//GO:0016614//GO:0016705//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- -- -- Cluster-8309.65418 BP_3 20.63 0.48 2351 642924462 XP_008194308.1 1131 1.1e-120 PREDICTED: G2/mitotic-specific cyclin-B3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05868 CCNB cyclin B http://www.genome.jp/dbget-bin/www_bget?ko:K05868 Q9I7I0 672 7.5e-69 G2/mitotic-specific cyclin-B3 OS=Drosophila melanogaster GN=CycB3 PE=1 SV=1 PF05830//PF02984 Nodulation protein Z (NodZ)//Cyclin, C-terminal domain GO:0009877//GO:0009312 nodulation//oligosaccharide biosynthetic process GO:0016758 transferase activity, transferring hexosyl groups GO:0005634 nucleus KOG0654 G2/Mitotic-specific cyclin A Cluster-8309.65419 BP_3 18.00 1.17 1034 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65422 BP_3 66.00 1.03 3377 270004765 EFA01213.1 509 2.1e-48 hypothetical protein TcasGA2_TC010540 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 313 4.6e-27 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.65424 BP_3 3.00 0.47 598 242018452 XP_002429689.1 347 2.2e-30 fatty acid synthase, putative [Pediculus humanus corporis]>gi|212514692|gb|EEB16951.1| fatty acid synthase, putative [Pediculus humanus corporis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 259 1.5e-21 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 -- -- GO:0006633//GO:0008152//GO:0042967 fatty acid biosynthetic process//metabolic process//acyl-carrier-protein biosynthetic process GO:0005488//GO:0016829//GO:0016297//GO:0016491 binding//lyase activity//acyl-[acyl-carrier-protein] hydrolase activity//oxidoreductase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.65426 BP_3 1.00 0.77 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6543 BP_3 165.70 3.74 2430 270008682 EFA05130.1 542 2.2e-52 hypothetical protein TcasGA2_TC015245 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13892//PF01607 DNA-binding domain//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061//GO:0003677 chitin binding//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.65431 BP_3 29.19 0.47 3284 357611789 EHJ67650.1 1126 5.8e-120 hypothetical protein KGM_11902 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12125 D domain of beta-TrCP -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.65432 BP_3 9.00 0.59 1023 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65436 BP_3 13.00 0.76 1117 270012045 EFA08493.1 223 1.0e-15 hypothetical protein TcasGA2_TC006145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.65437 BP_3 7.00 0.55 905 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65438 BP_3 56.80 0.79 3767 642937090 XP_008198688.1 885 5.9e-92 PREDICTED: nose resistant to fluoxetine protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 330 5.5e-29 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.6544 BP_3 39.00 7.19 553 642925599 XP_008194616.1 257 5.7e-20 PREDICTED: hornerin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.65441 BP_3 22.78 0.71 1847 642928686 XP_008199736.1 1187 2.7e-127 PREDICTED: orexin receptor type 1-like isoform X2 [Tribolium castaneum] 768433263 XM_011559691.1 93 1.66324e-38 PREDICTED: Plutella xylostella orexin receptor type 1-like (LOC105388735), mRNA K04239 HCRTR2 hypocretin (orexin) receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04239 P56719 597 2.9e-60 Orexin receptor type 2 OS=Rattus norvegicus GN=Hcrtr2 PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.65442 BP_3 4.00 2.84 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65443 BP_3 7.00 0.33 1309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609 Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-8309.65444 BP_3 36.00 0.51 3700 478256332 ENN76522.1 939 3.1e-98 hypothetical protein YQE_06973, partial [Dendroctonus ponderosae]>gi|546676292|gb|ERL87329.1| hypothetical protein D910_04724 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65446 BP_3 2.00 0.59 455 358442118 AEU11364.1 238 7.4e-18 Broad-complex protein isoform 6 variant 1 [Penaeus monodon] -- -- -- -- -- -- -- -- -- Q7KRI2 207 1.2e-15 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.65447 BP_3 13.85 0.59 1430 642929422 XP_008195833.1 670 1.9e-67 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] 642929423 XM_008197612.1 78 2.79141e-30 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X2, mRNA -- -- -- -- Q9DE13 303 2.8e-26 Bromodomain adjacent to zinc finger domain protein 2B OS=Gallus gallus GN=BAZ2B PE=2 SV=1 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.6545 BP_3 64.00 8.68 647 642925599 XP_008194616.1 279 1.9e-22 PREDICTED: hornerin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07382//PF01607 Histone H1-like nucleoprotein HC2//Chitin binding Peritrophin-A domain GO:0006030//GO:0030261 chitin metabolic process//chromosome condensation GO:0003677//GO:0008061 DNA binding//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.65455 BP_3 6.00 0.73 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65456 BP_3 55.81 3.20 1132 270003610 EFA00058.1 220 2.3e-15 hypothetical protein TcasGA2_TC002866 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65458 BP_3 127.00 3.60 1990 805809223 XP_012146792.1 1219 5.8e-131 PREDICTED: serine proteinase stubble isoform X1 [Megachile rotundata]>gi|805809226|ref|XP_012146793.1| PREDICTED: serine proteinase stubble isoform X1 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q05319 1118 1.2e-120 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.6546 BP_3 1.00 17.59 229 832041502 XP_012765667.1 143 3.9e-07 conserved Plasmodium protein, unknown function [Plasmodium reichenowi]>gi|641579033|emb|CDO67088.1| conserved Plasmodium protein, unknown function [Plasmodium reichenowi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07382 Histone H1-like nucleoprotein HC2 GO:0030261 chromosome condensation GO:0003677 DNA binding -- -- -- -- Cluster-8309.65463 BP_3 3.00 0.67 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65464 BP_3 2.00 23.50 239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65465 BP_3 7.00 1.69 491 189236864 XP_001814069.1 251 2.5e-19 PREDICTED: LIRP [Tribolium castaneum]>gi|270006470|gb|EFA02918.1| insulin-like peptide [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03488//PF00049 Nematode insulin-related peptide beta type//Insulin/IGF/Relaxin family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.65468 BP_3 130.58 1.60 4224 270004916 EFA01364.1 659 1.1e-65 hypothetical protein TcasGA2_TC010349 [Tribolium castaneum] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 E1JI63 266 1.6e-21 Sensory neuron membrane protein 2 OS=Drosophila melanogaster GN=Snmp2 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.65469 BP_3 38.42 0.77 2707 642917965 XP_008198962.1 902 4.5e-94 PREDICTED: sensory neuron membrane protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1JI63 520 3.6e-51 Sensory neuron membrane protein 2 OS=Drosophila melanogaster GN=Snmp2 PE=2 SV=1 PF00064//PF01130 Neuraminidase//CD36 family GO:0006687//GO:0005975//GO:0007155 glycosphingolipid metabolic process//carbohydrate metabolic process//cell adhesion GO:0004308 exo-alpha-sialidase activity GO:0033644//GO:0055036//GO:0016020 host cell membrane//virion membrane//membrane KOG3776 Plasma membrane glycoprotein CD36 and related membrane receptors Cluster-8309.65471 BP_3 3.00 0.47 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65474 BP_3 20.36 0.70 1702 270013873 EFA10321.1 870 1.5e-90 hypothetical protein TcasGA2_TC012537 [Tribolium castaneum] -- -- -- -- -- K08741 MSH5 DNA mismatch repair protein MSH5 http://www.genome.jp/dbget-bin/www_bget?ko:K08741 O43196 563 2.4e-56 MutS protein homolog 5 OS=Homo sapiens GN=MSH5 PE=1 SV=1 PF00004//PF05192//PF03266//PF00005//PF00488//PF01637 ATPase family associated with various cellular activities (AAA)//MutS domain III//NTPase//ABC transporter//MutS domain V//Archaeal ATPase GO:0006298 mismatch repair GO:0030983//GO:0016887//GO:0098519//GO:0005524 mismatched DNA binding//ATPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding -- -- KOG0221 Mismatch repair ATPase MSH5 (MutS family) Cluster-8309.65475 BP_3 8.00 0.75 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65476 BP_3 10.00 2.21 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65478 BP_3 3.00 0.37 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01943 Polysaccharide biosynthesis protein GO:0000271 polysaccharide biosynthetic process -- -- GO:0016020 membrane -- -- Cluster-8309.65479 BP_3 1.00 2.12 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65480 BP_3 1.00 3.03 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65481 BP_3 101.75 14.76 624 642924229 XP_008194207.1 327 4.9e-28 PREDICTED: pupal cuticle protein 20-like [Tribolium castaneum]>gi|270006759|gb|EFA03207.1| hypothetical protein TcasGA2_TC013127 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 229 4.7e-18 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379//PF07297 Insect cuticle protein//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) GO:0009059 macromolecule biosynthetic process GO:0042302 structural constituent of cuticle GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.65483 BP_3 86.25 15.79 555 642924229 XP_008194207.1 327 4.4e-28 PREDICTED: pupal cuticle protein 20-like [Tribolium castaneum]>gi|270006759|gb|EFA03207.1| hypothetical protein TcasGA2_TC013127 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 229 4.1e-18 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF07297//PF00379 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Insect cuticle protein GO:0009059 macromolecule biosynthetic process GO:0042302 structural constituent of cuticle GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.65486 BP_3 1.00 1.01 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65487 BP_3 73.00 1.19 3239 357610713 EHJ67109.1 149 1.1e-06 transposase [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65489 BP_3 2.00 0.53 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65490 BP_3 2.00 2.50 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65491 BP_3 73.41 1.42 2789 270012638 EFA09086.1 272 5.2e-21 hypothetical protein TcasGA2_TC006806 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04362//PF07527 Bacterial Fe(2+) trafficking//Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005506 DNA binding//iron ion binding -- -- -- -- Cluster-8309.65494 BP_3 2.00 0.63 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65495 BP_3 26.00 0.62 2327 749755206 XP_011140074.1 578 1.4e-56 PREDICTED: nesprin-1 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00435//PF01295 Spectrin repeat//Adenylate cyclase, class-I GO:0006171//GO:0006144 cAMP biosynthetic process//purine nucleobase metabolic process GO:0005515//GO:0004016 protein binding//adenylate cyclase activity -- -- -- -- Cluster-8309.65497 BP_3 190.55 24.47 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65498 BP_3 19.00 0.81 1428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65508 BP_3 39.00 3.47 833 324028132 ADY16617.1 1145 9.2e-123 ribosomal protein S3a [Fenneropenaeus merguiensis] 262401376 FJ774870.1 661 0 Scylla paramamosain S3Ae ribosomal protein-like protein mRNA, partial cds K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 Q6EV04 968 1.3e-103 40S ribosomal protein S3a OS=Biphyllus lunatus PE=2 SV=1 PF04083//PF05652//PF01015 Partial alpha/beta-hydrolase lipase region//Scavenger mRNA decapping enzyme (DcpS) N-terminal//Ribosomal S3Ae family GO:0042254//GO:0000290//GO:0006629//GO:0006412 ribosome biogenesis//deadenylation-dependent decapping of nuclear-transcribed mRNA//lipid metabolic process//translation GO:0003735//GO:0016787 structural constituent of ribosome//hydrolase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1628 40S ribosomal protein S3A Cluster-8309.6551 BP_3 1.00 0.51 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65510 BP_3 41.02 0.51 4161 642929979 XP_008196051.1 895 4.5e-93 PREDICTED: centromere-associated protein E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06386 Gas vesicle synthesis protein GvpL/GvpF GO:0031412 gas vesicle organization -- -- GO:0031411 gas vesicle -- -- Cluster-8309.65513 BP_3 41.00 4.99 688 262401117 ACY66461.1 724 5.0e-74 translationally controlled tumor protein [Scylla paramamosain] 262401116 FJ774739.1 531 0 Scylla paramamosain translationally controlled tumor protein mRNA, partial cds -- -- -- -- Q7QCK2 392 6.4e-37 Translationally-controlled tumor protein homolog OS=Anopheles gambiae GN=Tctp PE=3 SV=2 -- -- -- -- -- -- -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.65514 BP_3 4.00 0.52 662 805766866 XP_012135376.1 142 1.5e-06 PREDICTED: uncharacterized protein LOC105661843 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65517 BP_3 5.01 0.60 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65518 BP_3 6.00 0.60 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65522 BP_3 44.68 1.16 2146 642930553 XP_966739.2 1747 3.7e-192 PREDICTED: uncharacterized protein LOC655137 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65523 BP_3 87.08 2.29 2128 642930553 XP_966739.2 1752 9.6e-193 PREDICTED: uncharacterized protein LOC655137 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65524 BP_3 2.00 6.98 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65525 BP_3 122.43 1.95 3321 270015610 EFA12058.1 985 1.3e-103 hypothetical protein TcasGA2_TC012902 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96QF7 383 3.4e-35 Acidic repeat-containing protein OS=Homo sapiens GN=ACRC PE=2 SV=1 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0030942 7S RNA binding//endoplasmic reticulum signal peptide binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3854 SPRT-like metalloprotease Cluster-8309.65526 BP_3 30.96 0.97 1825 642925822 XP_008190442.1 400 4.9e-36 PREDICTED: uncharacterized protein LOC103312193 [Tribolium castaneum]>gi|270008612|gb|EFA05060.1| hypothetical protein TcasGA2_TC015155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BXJ7 208 3.7e-15 Protein amnionless OS=Homo sapiens GN=AMN PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65530 BP_3 23.00 1.45 1054 -- -- -- -- -- 768311752 CP010980.1 1048 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- P19752 551 3.6e-55 30 kDa heat shock protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=hsp30 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65533 BP_3 13.00 0.42 1780 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65535 BP_3 10.00 1.60 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65539 BP_3 20.00 2.23 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65542 BP_3 253.00 14.22 1149 288440 CAA51290.1 190 6.9e-12 acp-22 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P26968 181 3.1e-12 Adult-specific cuticular protein ACP-22 OS=Tenebrio molitor GN=ACP22 PE=2 SV=1 PF03839 Translocation protein Sec62 GO:0015031 protein transport GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.65543 BP_3 25.00 0.37 3521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13014//PF00013 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.65544 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65550 BP_3 8.03 0.38 1299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-8309.65555 BP_3 6.47 0.82 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65561 BP_3 5.00 0.40 887 766918703 XP_011499837.1 1208 4.8e-130 PREDICTED: LOW QUALITY PROTEIN: dystrophin, isoform B-like [Ceratosolen solmsi marchali] 223414363 FJ478146.1 51 1.74402e-15 Scylla serrata urate oxidase mRNA, partial cds K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q9VDW6 1060 2.9e-114 Dystrophin, isoforms A/C/F/G/H OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF00569//PF06657//PF04977//PF07649 Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57//Septum formation initiator//C1-like domain GO:0007049//GO:0055114 cell cycle//oxidation-reduction process GO:0047134//GO:0008270//GO:0008017 protein-disulfide reductase activity//zinc ion binding//microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.65562 BP_3 7.00 0.66 800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65564 BP_3 4.00 0.33 880 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65565 BP_3 7.00 0.37 1203 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65569 BP_3 3.00 3.19 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6557 BP_3 3.00 0.38 675 546684414 ERL94061.1 154 6.1e-08 hypothetical protein D910_11344 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65570 BP_3 26.85 1.18 1393 91076706 XP_972155.1 856 5.0e-89 PREDICTED: peroxisome biogenesis factor 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AUE5 312 2.5e-27 Peroxisome biogenesis factor 10 OS=Mus musculus GN=Pex10 PE=2 SV=1 PF16685//PF13639//PF14634//PF13371//PF12678//PF00097 zinc RING finger of MSL2//Ring finger domain//zinc-RING finger domain//Tetratricopeptide repeat//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) -- -- GO:0061630//GO:0046872//GO:0005515//GO:0008270 ubiquitin protein ligase activity//metal ion binding//protein binding//zinc ion binding -- -- KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein Cluster-8309.65574 BP_3 5.00 0.57 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65577 BP_3 10.00 0.52 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65581 BP_3 4.00 0.45 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65583 BP_3 37.05 0.72 2762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65584 BP_3 3.00 0.36 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65589 BP_3 11.00 25.70 290 91091644 XP_970770.1 214 2.9e-15 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000890|gb|EEZ97337.1| hypothetical protein TcasGA2_TC011149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 174 5.1e-12 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379//PF00978 Insect cuticle protein//RNA dependent RNA polymerase GO:0006144//GO:0006351 purine nucleobase metabolic process//transcription, DNA-templated GO:0042302//GO:0003968//GO:0003723 structural constituent of cuticle//RNA-directed RNA polymerase activity//RNA binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.65590 BP_3 1.00 2.02 296 478255481 ENN75698.1 134 5.5e-06 hypothetical protein YQE_07659, partial [Dendroctonus ponderosae]>gi|546676737|gb|ERL87693.1| hypothetical protein D910_05083 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65592 BP_3 360.99 68.14 547 478255481 ENN75698.1 254 1.3e-19 hypothetical protein YQE_07659, partial [Dendroctonus ponderosae]>gi|546676737|gb|ERL87693.1| hypothetical protein D910_05083 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 196 2.7e-14 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65599 BP_3 191.00 11.11 1120 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.656 BP_3 16.00 0.97 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14554//PF07850 VEGF heparin-binding domain//Renin receptor-like protein GO:0007165 signal transduction GO:0008201//GO:0004872 heparin binding//receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.65603 BP_3 6.82 1.34 537 646709569 KDR15369.1 331 1.4e-28 Programmed cell death protein 10 [Zootermopsis nevadensis] -- -- -- -- -- K18269 PDCD10 programmed cell death protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18269 Q6PHH3 149 7.5e-09 Programmed cell death protein 10-A OS=Danio rerio GN=pdcd10a PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4025 Putative apoptosis related protein Cluster-8309.65605 BP_3 5.00 2.66 380 861651240 KMQ97669.1 258 3.0e-20 e3 ubiquitin-protein ligase ubr3 [Lasius niger] -- -- -- -- -- K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 186 2.7e-13 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65606 BP_3 6.00 1.94 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65607 BP_3 13.61 0.31 2409 270017036 EFA13482.1 193 6.5e-12 hypothetical protein TcasGA2_TC002033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6561 BP_3 160.13 3.49 2505 189236336 XP_001816307.1 2221 4.7e-247 PREDICTED: general transcription factor IIH subunit 1 [Tribolium castaneum]>gi|270005862|gb|EFA02310.1| hypothetical protein TcasGA2_TC007976 [Tribolium castaneum] -- -- -- -- -- K03141 TFIIH1, GTF2H1, TFB1 transcription initiation factor TFIIH subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03141 Q960E8 1597 4.4e-176 General transcription factor IIH subunit 1 OS=Drosophila melanogaster GN=Tfb1 PE=2 SV=1 PF07289 Protein of unknown function (DUF1448) -- -- -- -- GO:0034464 BBSome KOG2074 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB1 Cluster-8309.65611 BP_3 2.00 0.46 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65612 BP_3 1.00 1.35 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65616 BP_3 4.49 0.31 995 157115780 XP_001652693.1 166 3.6e-09 AAEL007344-PA [Aedes aegypti]>gi|108876761|gb|EAT40986.1| AAEL007344-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65618 BP_3 3.51 0.34 794 157115780 XP_001652693.1 169 1.3e-09 AAEL007344-PA [Aedes aegypti]>gi|108876761|gb|EAT40986.1| AAEL007344-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65619 BP_3 2.00 0.31 605 157115780 XP_001652693.1 171 5.8e-10 AAEL007344-PA [Aedes aegypti]>gi|108876761|gb|EAT40986.1| AAEL007344-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65620 BP_3 2.00 0.41 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65623 BP_3 30.07 0.41 3857 642933871 XP_974162.3 1216 2.5e-130 PREDICTED: uncharacterized protein LOC663002 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q6PA23 356 5.4e-32 Lipase member H-A OS=Xenopus laevis GN=liph-a PE=2 SV=1 PF08476//PF01674//PF00975 Viral D10 N-terminal//Lipase (class 2)//Thioesterase domain GO:0009058 biosynthetic process GO:0016787//GO:0016788//GO:0016791 hydrolase activity//hydrolase activity, acting on ester bonds//phosphatase activity -- -- -- -- Cluster-8309.65624 BP_3 29.42 0.45 3436 642933871 XP_974162.3 1024 4.1e-108 PREDICTED: uncharacterized protein LOC663002 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q8VBX1 357 3.7e-32 Endothelial lipase OS=Rattus norvegicus GN=Lipg PE=2 SV=2 PF08476 Viral D10 N-terminal -- -- GO:0016791 phosphatase activity -- -- -- -- Cluster-8309.65626 BP_3 509.00 17.88 1664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65631 BP_3 1.00 1.69 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05694 56kDa selenium binding protein (SBP56) -- -- GO:0008430 selenium binding -- -- -- -- Cluster-8309.65634 BP_3 2.00 0.37 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04196 Bunyavirus RNA dependent RNA polymerase GO:0006144//GO:0019079//GO:0006351 purine nucleobase metabolic process//viral genome replication//transcription, DNA-templated GO:0003968 RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.65635 BP_3 2.65 0.56 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65636 BP_3 5.00 0.34 991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65637 BP_3 33.00 0.58 3034 91094247 XP_968717.1 2757 4.0e-309 PREDICTED: sodium-dependent serotonin transporter [Tribolium castaneum]>gi|270016267|gb|EFA12713.1| hypothetical protein TcasGA2_TC002347 [Tribolium castaneum] 24415089 AF384164.1 241 1.46806e-120 Manduca sexta high-affinity serotonin transporter mRNA, complete cds K05037 SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05037 P51905 2232 1.2e-249 Sodium-dependent serotonin transporter OS=Drosophila melanogaster GN=SerT PE=2 SV=1 PF00209//PF14984 Sodium:neurotransmitter symporter family//CD24 protein GO:0006836//GO:0006812//GO:0007155 neurotransmitter transport//cation transport//cell adhesion GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3659 Sodium-neurotransmitter symporter Cluster-8309.65638 BP_3 1470.00 15.75 4791 642923976 XP_008193949.1 3547 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270008240|gb|EFA04688.1| tartan/capricious-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35858 447 1.9e-42 Insulin-like growth factor-binding protein complex acid labile subunit OS=Homo sapiens GN=IGFALS PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.6564 BP_3 5.87 3.82 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65640 BP_3 4.00 0.34 852 694524478 XP_009492165.1 173 4.8e-10 hypothetical protein H696_00056 [Fonticula alba]>gi|627950675|gb|KCV72464.1| hypothetical protein H696_00056 [Fonticula alba] 768311754 CP010982.1 837 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- P22697 328 2.1e-29 Regulatory protein cys-3 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cys-3 PE=1 SV=1 PF01166//PF07716//PF00170 TSC-22/dip/bun family//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.65643 BP_3 10.00 0.31 1842 270016639 EFA13085.1 2066 3.3e-229 hypothetical protein TcasGA2_TC011585 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7P9 489 9.8e-48 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF03094 Integrase core domain//Mlo family GO:0006952//GO:0015074 defense response//DNA integration -- -- GO:0016021 integral component of membrane KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.65646 BP_3 7.00 0.93 653 768410548 XP_011558883.1 168 1.4e-09 PREDICTED: uncharacterized protein LOC105389466, partial [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65650 BP_3 3.00 1.16 415 642918194 XP_008191406.1 316 6.1e-27 PREDICTED: protein APCDD1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65651 BP_3 5.00 0.48 789 478255830 ENN76038.1 704 1.2e-71 hypothetical protein YQE_07411, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5R2I8 270 1.0e-22 Protein APCDD1 OS=Gallus gallus GN=APCDD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65652 BP_3 5.00 0.45 822 270003303 EEZ99750.1 384 1.6e-34 hypothetical protein TcasGA2_TC002519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NCL9 209 1.3e-15 Protein APCDD1-like OS=Homo sapiens GN=APCDD1L PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65653 BP_3 2.00 0.60 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65654 BP_3 9.31 0.39 1457 -- -- -- -- -- 13241679 AF321227.1 65 4.79523e-23 AF321227 Tribolium castaneum Ftz (ftz), Scr (scr), Dfd (dfd), Zen (zen), and Zen2 (zen2) genes, complete cds; and Pb (pb) gene, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65656 BP_3 2.00 0.46 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65657 BP_3 5.72 0.61 744 270017158 EFA13604.1 387 6.4e-35 hypothetical protein TcasGA2_TC010302 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6566 BP_3 3.00 0.79 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65661 BP_3 18.05 1.80 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65666 BP_3 4.00 1.07 472 434785 BAA03463.1 202 1.2e-13 actin [Procambarus clarkii] 724908519 XM_010380427.1 106 2.39261e-46 PREDICTED: Rhinopithecus roxellana actin, muscle-like (LOC104675775), transcript variant X2, mRNA K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 P45521 202 4.8e-15 Actin (Fragment) OS=Procambarus clarkii PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.65667 BP_3 28.00 0.66 2339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6567 BP_3 58.00 0.59 5033 270011681 EFA08129.1 2881 0.0e+00 hypothetical protein TcasGA2_TC005733 [Tribolium castaneum] 642932005 XM_008198594.1 320 2.97005e-164 PREDICTED: Tribolium castaneum kinesin 8B (LOC663478), mRNA K10401 KIF18_19 kinesin family member 18/19 http://www.genome.jp/dbget-bin/www_bget?ko:K10401 Q7ZXX2 1365 7.0e-149 Kinesin-like protein KIF19 OS=Xenopus laevis GN=kif19 PE=2 SV=1 PF00225//PF06009//PF06085//PF02931//PF02932 Kinesin motor domain//Laminin Domain II//Lipoprotein Rz1 precursor//Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0007155//GO:0007017//GO:0019064//GO:0006810//GO:0007018 ion transport//cell adhesion//microtubule-based process//fusion of virus membrane with host plasma membrane//transport//microtubule-based movement GO:0008017//GO:0005230//GO:0003777//GO:0005524 microtubule binding//extracellular ligand-gated ion channel activity//microtubule motor activity//ATP binding GO:0016020//GO:0045298//GO:0005874//GO:0019867 membrane//tubulin complex//microtubule//outer membrane KOG0242 Kinesin-like protein Cluster-8309.65670 BP_3 13.00 0.32 2249 478257790 ENN77933.1 343 2.5e-29 hypothetical protein YQE_05610, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65672 BP_3 58.03 2.47 1422 189240378 XP_001814021.1 684 4.5e-69 PREDICTED: uncharacterized protein LOC100141739 [Tribolium castaneum]>gi|270012459|gb|EFA08907.1| hypothetical protein TcasGA2_TC006612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65674 BP_3 22.79 0.64 1999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65676 BP_3 6.00 1.85 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6568 BP_3 2.00 0.33 584 749754730 XP_011139815.1 941 2.9e-99 PREDICTED: LOW QUALITY PROTEIN: splicing factor 3B subunit 1-like [Harpegnathos saltator] 462302537 APGK01050185.1 351 0 Dendroctonus ponderosae Seq01050195, whole genome shotgun sequence K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O75533 912 2.8e-97 Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.65680 BP_3 23.00 0.55 2292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65685 BP_3 66.01 0.96 3591 270004055 EFA00503.1 2932 0.0e+00 hypothetical protein TcasGA2_TC003365 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RW7 196 1.8e-13 Hemicentin-1 OS=Homo sapiens GN=HMCN1 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.65686 BP_3 37.59 1.63 1406 642911411 XP_008199411.1 452 3.5e-42 PREDICTED: lachesin-like isoform X1 [Tribolium castaneum] 642911414 XM_008201191.1 46 1.68651e-12 PREDICTED: Tribolium castaneum lachesin-like (LOC661289), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65689 BP_3 98.55 1.21 4232 642919551 XP_008191919.1 1553 2.3e-169 PREDICTED: synaptotagmin-12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IV01 512 4.8e-50 Synaptotagmin-12 OS=Homo sapiens GN=SYT12 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.65690 BP_3 68.02 1.27 2875 642927192 XP_008195174.1 3042 0.0e+00 PREDICTED: centrosomal protein of 104 kDa [Tribolium castaneum] -- -- -- -- -- K16458 CEP104 centrosomal protein CEP104 http://www.genome.jp/dbget-bin/www_bget?ko:K16458 O60308 897 7.5e-95 Centrosomal protein of 104 kDa OS=Homo sapiens GN=CEP104 PE=1 SV=1 PF02151 UvrB/uvrC motif -- -- GO:0005515 protein binding -- -- KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa) Cluster-8309.65697 BP_3 13.00 0.82 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65703 BP_3 6.00 1.79 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65715 BP_3 2.00 1.06 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65716 BP_3 1.00 2.59 286 307198709 EFN79524.1 185 6.5e-12 hypothetical protein EAI_06736, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65717 BP_3 3.00 0.50 579 746849727 XP_011055317.1 346 2.8e-30 PREDICTED: uncharacterized protein LOC105146626 isoform X1 [Acromyrmex echinatior]>gi|746849729|ref|XP_011055318.1| PREDICTED: uncharacterized protein LOC105146626 isoform X2 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65722 BP_3 19.00 1.79 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65725 BP_3 13.00 7.21 376 328899855 AEB54651.1 472 4.5e-45 ribosomal protein S9 [Procambarus clarkii] -- -- -- -- -- K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 P55935 368 2.1e-34 40S ribosomal protein S9 OS=Drosophila melanogaster GN=RpS9 PE=1 SV=2 PF00163//PF01022 Ribosomal protein S4/S9 N-terminal domain//Bacterial regulatory protein, arsR family GO:0006355 regulation of transcription, DNA-templated GO:0019843//GO:0003700 rRNA binding//transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex KOG3301 Ribosomal protein S4 Cluster-8309.65727 BP_3 2.00 1.52 350 328899855 AEB54651.1 441 1.7e-41 ribosomal protein S9 [Procambarus clarkii] 262401346 FJ774855.1 175 7.59589e-85 Scylla paramamosain ribosomal protein S9e mRNA, partial cds K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 P55935 414 9.2e-40 40S ribosomal protein S9 OS=Drosophila melanogaster GN=RpS9 PE=1 SV=2 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG3301 Ribosomal protein S4 Cluster-8309.6573 BP_3 10.00 1.17 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65738 BP_3 39.20 1.51 1542 642937330 XP_966361.3 778 6.1e-80 PREDICTED: serine proteinase stubble, partial [Tribolium castaneum] 642937329 XM_961268.2 64 1.82776e-22 PREDICTED: Tribolium castaneum serine protease P126 (LOC654852), partial mRNA -- -- -- -- Q05319 272 1.2e-22 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF02060 Slow voltage-gated potassium channel GO:0006811//GO:0006813 ion transport//potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0008076//GO:0016020 voltage-gated potassium channel complex//membrane -- -- Cluster-8309.65741 BP_3 34.40 0.57 3194 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65745 BP_3 99.00 1.83 2898 270003131 EEZ99578.1 1734 1.6e-190 hypothetical protein TcasGA2_TC001564 [Tribolium castaneum] -- -- -- -- -- K01273 DPEP membrane dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01273 P22412 924 5.6e-98 Dipeptidase 1 OS=Sus scrofa GN=DPEP1 PE=1 SV=1 PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- KOG4127 Renal dipeptidase Cluster-8309.65752 BP_3 1.00 0.67 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65762 BP_3 1.00 0.35 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65768 BP_3 8.00 0.53 1020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6577 BP_3 1.00 0.38 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65773 BP_3 1.00 0.32 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65777 BP_3 9.44 1.16 683 642933417 XP_008197409.1 177 1.3e-10 PREDICTED: cytochrome P450 9e2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65778 BP_3 6.00 5.69 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65781 BP_3 6.00 1.43 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65785 BP_3 28.00 0.38 3838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65786 BP_3 39.57 1.43 1621 332373060 AEE61671.1 1049 2.4e-111 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65788 BP_3 18.00 0.63 1667 270006574 EFA03022.1 446 2.1e-41 hypothetical protein TcasGA2_TC010445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65789 BP_3 10.00 0.34 1715 478251488 ENN71951.1 279 5.0e-22 hypothetical protein YQE_11385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65790 BP_3 18.00 0.75 1450 270006574 EFA03022.1 865 4.7e-90 hypothetical protein TcasGA2_TC010445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.65794 BP_3 12.71 0.40 1824 270015294 EFA11742.1 806 4.1e-83 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836//PF02217//PF00096 RasGAP C-terminus//Origin of replication binding protein//Zinc finger, C2H2 type GO:0006260//GO:0007264 DNA replication//small GTPase mediated signal transduction GO:0003688//GO:0005096//GO:0046872 DNA replication origin binding//GTPase activator activity//metal ion binding GO:0046809 replication compartment -- -- Cluster-8309.65799 BP_3 37.99 0.71 2884 642940025 XP_008191587.1 1881 1.4e-207 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 Q62077 1294 6.9e-141 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Mus musculus GN=Plcg1 PE=1 SV=2 PF13499//PF13833//PF13405//PF00036 EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG1264 Phospholipase C Cluster-8309.658 BP_3 36.00 1.37 1556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65800 BP_3 8.00 0.36 1357 -- -- -- -- -- 697088446 XM_009658839.1 863 0 Verticillium dahliae VdLs.17 elicitor protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65807 BP_3 156.00 6.53 1443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04644 Motilin/ghrelin GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.65813 BP_3 7.00 0.58 877 675762778 XP_008972919.1 1385 1.4e-150 PREDICTED: NF-kappa-B inhibitor alpha [Pan paniscus]>gi|795222276|ref|XP_011850425.1| PREDICTED: NF-kappa-B inhibitor alpha isoform X1 [Mandrillus leucophaeus] 168693660 NM_020529.2 877 0 Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA), mRNA K04734 NFKBIA NF-kappa-B inhibitor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04734 P25963 1388 2.6e-152 NF-kappa-B inhibitor alpha OS=Homo sapiens GN=NFKBIA PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.65814 BP_3 9327.56 330.75 1651 642914380 XP_008201654.1 393 2.9e-35 PREDICTED: keratin, type I cytoskeletal 9-like [Tribolium castaneum]>gi|270001553|gb|EEZ98000.1| hypothetical protein TcasGA2_TC000398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65815 BP_3 4.00 1.42 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11857 Domain of unknown function (DUF3377) -- -- GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.65816 BP_3 2.00 0.98 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65828 BP_3 17.57 0.61 1675 688549365 XP_009298810.1 614 6.9e-61 PREDICTED: zinc finger protein 135-like [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 577 5.5e-58 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF16622//PF07776//PF13912//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.65829 BP_3 412.59 14.02 1710 642917985 XP_008198971.1 1087 1.0e-115 PREDICTED: uncharacterized protein LOC103314498 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65834 BP_3 4.00 0.40 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65836 BP_3 8.00 0.78 786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65837 BP_3 1.00 0.71 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65839 BP_3 4.00 0.33 883 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6584 BP_3 18.31 0.56 1881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65841 BP_3 7.00 1.04 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65842 BP_3 1.00 0.61 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65849 BP_3 2.00 0.49 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65850 BP_3 8562.22 372.71 1399 642914380 XP_008201654.1 159 3.3e-08 PREDICTED: keratin, type I cytoskeletal 9-like [Tribolium castaneum]>gi|270001553|gb|EEZ98000.1| hypothetical protein TcasGA2_TC000398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65851 BP_3 4.00 0.99 487 432110945 ELK34419.1 781 8.7e-81 Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha [Myotis davidii] 92446697 BC011791.1 487 0 Homo sapiens cDNA clone IMAGE:3959826, **** WARNING: chimeric clone **** K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 Q56JX8 769 8.8e-81 40S ribosomal protein S13 OS=Bos taurus GN=RPS13 PE=2 SV=3 PF00292//PF00312//PF08069 'Paired box' domain//Ribosomal protein S15//Ribosomal S13/S15 N-terminal domain GO:0006412//GO:0042254//GO:0006355 translation//ribosome biogenesis//regulation of transcription, DNA-templated GO:0003677//GO:0003735 DNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0400 40S ribosomal protein S13 Cluster-8309.65854 BP_3 17.38 0.78 1370 642914631 XP_008190292.1 393 2.4e-35 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0046872//GO:0016787//GO:0003676 metal ion binding//hydrolase activity//nucleic acid binding -- -- -- -- Cluster-8309.65855 BP_3 2.67 0.68 481 642934629 XP_972091.2 156 2.5e-08 PREDICTED: probable pyridoxamine 5'-phosphate oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01243//PF12766 Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase GO:0008615//GO:0055114 pyridoxine biosynthetic process//oxidation-reduction process GO:0010181//GO:0004733 FMN binding//pyridoxamine-phosphate oxidase activity -- -- -- -- Cluster-8309.6586 BP_3 1.00 0.47 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65863 BP_3 69.00 1.05 3468 478262642 ENN81206.1 565 6.9e-55 hypothetical protein YQE_02396, partial [Dendroctonus ponderosae] -- -- -- -- -- K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 Q4V7Q6 336 1.0e-29 Serine/threonine-protein kinase ULK3 OS=Xenopus laevis GN=ulk3 PE=2 SV=1 PF08502//PF07714//PF03829//PF02740//PF00069//PF06293 LeuA allosteric (dimerisation) domain//Protein tyrosine kinase//PTS system glucitol/sorbitol-specific IIA component//Colipase, C-terminal domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009401//GO:0006090//GO:0009099//GO:0009097//GO:0009098//GO:0006468//GO:0007586//GO:0016042//GO:0008643 phosphoenolpyruvate-dependent sugar phosphotransferase system//pyruvate metabolic process//valine biosynthetic process//isoleucine biosynthetic process//leucine biosynthetic process//protein phosphorylation//digestion//lipid catabolic process//carbohydrate transport GO:0005524//GO:0016773//GO:0008047//GO:0008982//GO:0004672//GO:0003852 ATP binding//phosphotransferase activity, alcohol group as acceptor//enzyme activator activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase activity//2-isopropylmalate synthase activity GO:0009357//GO:0005737//GO:0005576//GO:0016020 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//cytoplasm//extracellular region//membrane -- -- Cluster-8309.65866 BP_3 10.00 1.09 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65867 BP_3 52.21 1.11 2560 751463814 XP_011186824.1 1196 3.4e-128 PREDICTED: uncharacterized protein LOC105214855 [Bactrocera cucurbitae] 642940417 XM_008193059.1 212 1.63426e-104 PREDICTED: Tribolium castaneum poliovirus receptor-related protein 3-like (LOC103312443), partial mRNA -- -- -- -- Q9JLB9 175 3.5e-11 Nectin-3 OS=Mus musculus GN=Pvrl3 PE=1 SV=1 PF13895//PF08086 Immunoglobulin domain//Ergtoxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870//GO:0005515 potassium channel inhibitor activity//protein binding GO:0005576 extracellular region -- -- Cluster-8309.6587 BP_3 32.00 4.48 636 332374630 AEE62456.1 656 3.5e-66 unknown [Dendroctonus ponderosae]>gi|478258539|gb|ENN78610.1| hypothetical protein YQE_04914, partial [Dendroctonus ponderosae]>gi|478261717|gb|ENN80874.1| hypothetical protein YQE_02710, partial [Dendroctonus ponderosae]>gi|546673698|gb|ERL85259.1| hypothetical protein D910_02680 [Dendroctonus ponderosae]>gi|546674332|gb|ERL85733.1| hypothetical protein D910_03148 [Dendroctonus ponderosae] 262401304 FJ774834.1 276 1.03131e-140 Scylla paramamosain ribosomal protein L19e mRNA, partial cds K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 P36241 638 1.8e-65 60S ribosomal protein L19 OS=Drosophila melanogaster GN=RpL19 PE=1 SV=2 PF01280 Ribosomal protein L19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1696 60s ribosomal protein L19 Cluster-8309.65871 BP_3 3.00 0.46 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65875 BP_3 7.66 0.87 716 631250148 AHZ13215.1 225 3.8e-16 multicopper oxidase related protein, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65876 BP_3 14.81 0.32 2495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16944 Fungal potassium channel GO:0071805//GO:0006813 potassium ion transmembrane transport//potassium ion transport GO:0015079 potassium ion transmembrane transporter activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.65877 BP_3 26.00 0.99 1562 443722652 ELU11413.1 540 2.5e-52 hypothetical protein CAPTEDRAFT_171473 [Capitella teleta] 697081605 XM_009655923.1 1534 0 Verticillium dahliae VdLs.17 inositolphosphorylceramide-B C-26 hydroxylase mRNA -- -- -- -- Q03529 1043 4.8e-112 Ceramide very long chain fatty acid hydroxylase SCS7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCS7 PE=1 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- KOG0539 Sphingolipid fatty acid hydroxylase Cluster-8309.65880 BP_3 119.90 2.61 2503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65881 BP_3 169.32 3.63 2542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65893 BP_3 25.16 1.11 1383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65895 BP_3 69.00 1.34 2765 724951806 XP_010351937.1 2006 4.4e-222 PREDICTED: LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [Rhinopithecus roxellana] 697076761 XM_009654249.1 2138 0 Verticillium dahliae VdLs.17 heat shock protein partial mRNA K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 O43109 1720 2.6e-190 Heat shock protein 90 homolog OS=Podospora anserina GN=MOD-E PE=3 SV=1 PF00183//PF01213 Hsp90 protein//Adenylate cyclase associated (CAP) N terminal GO:0006457//GO:0006950//GO:0007010 protein folding//response to stress//cytoskeleton organization GO:0051082//GO:0005524//GO:0003779 unfolded protein binding//ATP binding//actin binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.65897 BP_3 5.00 0.50 772 -- -- -- -- -- 768311753 CP010981.1 375 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF02100 Ornithine decarboxylase antizyme GO:0019467 ornithine catabolic process, by decarboxylation GO:0008073//GO:0004857 ornithine decarboxylase inhibitor activity//enzyme inhibitor activity -- -- -- -- Cluster-8309.65898 BP_3 2.00 2.36 322 -- -- -- -- -- 768311753 CP010981.1 316 2.87706e-163 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.659 BP_3 5.00 0.55 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6590 BP_3 25.59 0.86 1733 719775592 XP_010220674.1 262 4.7e-20 PREDICTED: LOW QUALITY PROTEIN: activated CDC42 kinase 1-like [Tinamus guttatus] -- -- -- -- -- -- -- -- -- Q5U2X5 251 3.6e-20 Activated CDC42 kinase 1 OS=Rattus norvegicus GN=Tnk2 PE=2 SV=1 PF03117//PF00069//PF10576//PF07714//PF08923 UL49 family//Protein kinase domain//Iron-sulfur binding domain of endonuclease III//Protein tyrosine kinase//Mitogen-activated protein kinase kinase 1 interacting GO:0016032//GO:0032006//GO:0006468 viral process//regulation of TOR signaling//protein phosphorylation GO:0005524//GO:0051539//GO:0004672 ATP binding//4 iron, 4 sulfur cluster binding//protein kinase activity GO:0019033 viral tegument -- -- Cluster-8309.65901 BP_3 120.52 1.85 3427 642916500 XP_008191068.1 1851 5.2e-204 PREDICTED: paired box protein Pax-5 [Tribolium castaneum] 642916499 XM_008192846.1 582 0 PREDICTED: Tribolium castaneum paired box protein Pax-5 (LOC656415), mRNA K15608 PAX2 paired box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15608 O57685 638 9.6e-65 Paired box protein Pax-2-A OS=Xenopus laevis GN=pax2-a PE=2 SV=2 PF00292 'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.65903 BP_3 353.58 5.49 3395 642916500 XP_008191068.1 2016 3.8e-223 PREDICTED: paired box protein Pax-5 [Tribolium castaneum] 642916499 XM_008192846.1 639 0 PREDICTED: Tribolium castaneum paired box protein Pax-5 (LOC656415), mRNA K15608 PAX2 paired box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15608 O57685 656 7.8e-67 Paired box protein Pax-2-A OS=Xenopus laevis GN=pax2-a PE=2 SV=2 PF00292 'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.65904 BP_3 25.68 0.39 3427 642916500 XP_008191068.1 1829 1.8e-201 PREDICTED: paired box protein Pax-5 [Tribolium castaneum] 642916499 XM_008192846.1 540 0 PREDICTED: Tribolium castaneum paired box protein Pax-5 (LOC656415), mRNA K15608 PAX2 paired box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15608 O57682 681 9.9e-70 Paired box protein Pax-2-B OS=Xenopus laevis GN=pax2-b PE=2 SV=2 PF00292 'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.65905 BP_3 19.06 0.32 3196 642916500 XP_008191068.1 1401 7.3e-152 PREDICTED: paired box protein Pax-5 [Tribolium castaneum] 642916499 XM_008192846.1 468 0 PREDICTED: Tribolium castaneum paired box protein Pax-5 (LOC656415), mRNA K15608 PAX2 paired box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15608 O57685 634 2.6e-64 Paired box protein Pax-2-A OS=Xenopus laevis GN=pax2-a PE=2 SV=2 PF00292 'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.65908 BP_3 5.60 0.31 1171 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65909 BP_3 6.00 3.40 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6591 BP_3 7.00 0.60 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65913 BP_3 6.00 0.67 724 642936848 XP_008197887.1 163 5.9e-09 PREDICTED: salivary glue protein Sgs-3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.65918 BP_3 1.00 0.51 385 3915087 Q25009.1 573 9.0e-57 RecName: Full=Tubulin beta-1 chain; AltName: Full=Beta-I tubulin [Homarus americanus]>gi|1272242|gb|AAC47306.1| beta-I tubulin [Homarus americanus] 594114964 XM_006080132.1 164 1.09883e-78 PREDICTED: Bubalus bubalis tubulin, beta 2B class IIb (TUBB2B), mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q25009 573 3.7e-58 Tubulin beta-1 chain OS=Homarus americanus PE=2 SV=1 PF00091//PF01316 Tubulin/FtsZ family, GTPase domain//Arginine repressor, DNA binding domain GO:0006355//GO:0006525 regulation of transcription, DNA-templated//arginine metabolic process GO:0003924//GO:0003700 GTPase activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1375 Beta tubulin Cluster-8309.6592 BP_3 13.00 0.85 1032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65926 BP_3 1.00 0.49 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6593 BP_3 106.73 3.90 1612 478255874 ENN76082.1 2237 4.2e-249 hypothetical protein YQE_07453, partial [Dendroctonus ponderosae]>gi|546680435|gb|ERL90701.1| hypothetical protein D910_08048 [Dendroctonus ponderosae] -- -- -- -- -- K12847 USP39, SAD1 U4/U6.U5 tri-snRNP-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12847 Q3TIX9 1750 5.1e-194 U4/U6.U5 tri-snRNP-associated protein 2 OS=Mus musculus GN=Usp39 PE=2 SV=2 PF00738//PF00443//PF02148 Polyhedrin//Ubiquitin carboxyl-terminal hydrolase//Zn-finger in ubiquitin-hydrolases and other protein GO:0016579 protein deubiquitination GO:0005198//GO:0036459//GO:0008270 structural molecule activity//ubiquitinyl hydrolase activity//zinc ion binding -- -- KOG2026 Spindle pole body protein - Sad1p Cluster-8309.65934 BP_3 41.00 3.29 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65935 BP_3 1.00 4.87 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65936 BP_3 65.00 3.25 1257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6594 BP_3 224.03 12.30 1170 642936369 XP_008198411.1 769 5.1e-79 PREDICTED: transcription factor E2F5-like [Tribolium castaneum]>gi|270013125|gb|EFA09573.1| hypothetical protein TcasGA2_TC011687 [Tribolium castaneum] 572260333 XM_006608425.1 72 4.91618e-27 PREDICTED: Apis dorsata transcription factor E2F4-like (LOC102673706), transcript variant X2, mRNA K04682 E2F4_5 transcription factor E2F4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04682 Q62814 401 9.9e-38 Transcription factor E2F5 (Fragment) OS=Rattus norvegicus GN=E2f5 PE=2 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.65940 BP_3 5.00 0.40 901 380003174 AFD28274.1 291 1.1e-23 14-3-3 protein [Scylla paramamosain] 675324093 CP009081.1 888 0 Verticillium dahliae JR2 chromosome 8, complete sequence K06630 YWHAE 14-3-3 protein epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K06630 P29311 281 6.3e-24 Protein BMH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BMH1 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.65941 BP_3 5.00 0.46 817 761917307 XP_011407618.1 570 4.3e-56 PREDICTED: spermidine synthase-like [Amphimedon queenslandica] 768311753 CP010981.1 572 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence K00797 speE, SRM spermidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00797 Q9Y8H7 837 1.9e-88 Spermidine synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=spe-3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1562 Spermidine synthase Cluster-8309.65942 BP_3 43.00 2.05 1301 -- -- -- -- -- 768311755 CP010983.1 1298 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- PF05413//PF15724 Putative closterovirus papain-like endopeptidase//TMEM119 family GO:0001503//GO:0019079//GO:0006144 ossification//viral genome replication//purine nucleobase metabolic process GO:0003723//GO:0005524//GO:0003968 RNA binding//ATP binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.65946 BP_3 3.00 0.56 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65947 BP_3 1456.37 11.87 6204 642914122 XP_008201553.1 7430 0.0e+00 PREDICTED: cadherin-23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58365 1770 9.5e-196 Cadherin-23 OS=Rattus norvegicus GN=Cdh23 PE=2 SV=1 PF00028//PF08264 Cadherin domain//Anticodon-binding domain of tRNA GO:0006418//GO:0007156 tRNA aminoacylation for protein translation//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0000166 calcium ion binding//nucleotide binding GO:0016020 membrane -- -- Cluster-8309.65948 BP_3 10.19 0.31 1879 270002834 EEZ99281.1 1688 2.2e-185 cadherin 23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99PF4 470 1.6e-45 Cadherin-23 OS=Mus musculus GN=Cdh23 PE=1 SV=2 PF08264//PF00028//PF03824 Anticodon-binding domain of tRNA//Cadherin domain//High-affinity nickel-transport protein GO:0007156//GO:0015675//GO:0035444//GO:0006418 homophilic cell adhesion via plasma membrane adhesion molecules//nickel cation transport//nickel cation transmembrane transport//tRNA aminoacylation for protein translation GO:0046872//GO:0015099//GO:0000166//GO:0005509 metal ion binding//nickel cation transmembrane transporter activity//nucleotide binding//calcium ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG3594 FOG: Cadherin repeats Cluster-8309.65949 BP_3 349.17 2.82 6256 642914122 XP_008201553.1 6546 0.0e+00 PREDICTED: cadherin-23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58365 1505 5.1e-165 Cadherin-23 OS=Rattus norvegicus GN=Cdh23 PE=2 SV=1 PF08264//PF00028 Anticodon-binding domain of tRNA//Cadherin domain GO:0007156//GO:0006418 homophilic cell adhesion via plasma membrane adhesion molecules//tRNA aminoacylation for protein translation GO:0000166//GO:0005509 nucleotide binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.6595 BP_3 5.00 0.60 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65950 BP_3 304.36 2.42 6342 642914122 XP_008201553.1 7284 0.0e+00 PREDICTED: cadherin-23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58365 1758 2.4e-194 Cadherin-23 OS=Rattus norvegicus GN=Cdh23 PE=2 SV=1 PF00028//PF08264 Cadherin domain//Anticodon-binding domain of tRNA GO:0007156//GO:0006418 homophilic cell adhesion via plasma membrane adhesion molecules//tRNA aminoacylation for protein translation GO:0000166//GO:0005509 nucleotide binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.65953 BP_3 4.00 0.43 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65967 BP_3 4.16 0.40 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6597 BP_3 4.00 0.49 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6598 BP_3 173.99 4.02 2378 861641895 KMQ93718.1 1428 4.0e-155 serine threonine-protein kinase 36 [Lasius niger] 817083926 XM_012409166.1 66 2.19677e-23 PREDICTED: Athalia rosae serine/threonine-protein kinase fused (LOC105690966), transcript variant X2, mRNA K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 P23647 867 1.9e-91 Serine/threonine-protein kinase fused OS=Drosophila melanogaster GN=fu PE=1 SV=2 PF10598//PF06293//PF00069//PF07714 RNA recognition motif of the spliceosomal PrP8//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524//GO:0003723 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding//RNA binding GO:0016020 membrane KOG0580 Serine/threonine protein kinase Cluster-8309.65982 BP_3 48.25 0.59 4216 642916500 XP_008191068.1 316 6.2e-26 PREDICTED: paired box protein Pax-5 [Tribolium castaneum] 642916499 XM_008192846.1 142 2.21251e-65 PREDICTED: Tribolium castaneum paired box protein Pax-5 (LOC656415), mRNA -- -- -- -- -- -- -- -- PF03176 MMPL family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.65984 BP_3 389.00 2.80 6980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65987 BP_3 63.54 0.43 7467 -- -- -- -- -- 462361201 APGK01029141.1 48 7.06113e-13 Dendroctonus ponderosae Seq01029151, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65989 BP_3 9.21 0.62 1009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06151//PF08395 Trehalose receptor//7tm Chemosensory receptor GO:0050909//GO:0007187//GO:0050912//GO:0007607 sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.65992 BP_3 19.00 2.98 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65995 BP_3 45.49 1.73 1556 642939494 XP_008190865.1 1034 1.3e-109 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 Q7G193 442 2.3e-42 Indole-3-acetaldehyde oxidase OS=Arabidopsis thaliana GN=AAO1 PE=1 SV=2 PF00941//PF01799//PF00111 FAD binding domain in molybdopterin dehydrogenase//[2Fe-2S] binding domain//2Fe-2S iron-sulfur cluster binding domain GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0051536//GO:0046872//GO:0016491 electron carrier activity//iron-sulfur cluster binding//metal ion binding//oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.65997 BP_3 2.00 0.72 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66 BP_3 1.00 0.54 378 -- -- -- -- -- 116311084 CR855237.1 267 5.95416e-136 Oryza sativa genomic DNA, chromosome 4, BAC clone: H0807C06-H0308C08, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66001 BP_3 29.27 0.50 3094 817064418 XP_012253954.1 3468 0.0e+00 PREDICTED: gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [Athalia rosae] 13160941 AF318272.1 279 1.1253e-141 AF318272 Drosophila melanogaster metabotropic GABA-B receptor subtype 1 (GABA-B-R1) mRNA, complete cds K04615 GABBR gamma-aminobutyric acid type B receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04615 Q9UBS5 2015 1.8e-224 Gamma-aminobutyric acid type B receptor subunit 1 OS=Homo sapiens GN=GABBR1 PE=1 SV=1 PF00003//PF01769 7 transmembrane sweet-taste receptor of 3 GCPR//Divalent cation transporter GO:0006812//GO:0007186 cation transport//G-protein coupled receptor signaling pathway GO:0008324//GO:0004930 cation transmembrane transporter activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG1055 GABA-B ion channel receptor subunit GABABR1 and related subunits, G-protein coupled receptor superfamily Cluster-8309.66002 BP_3 16.85 0.45 2098 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66008 BP_3 3.00 0.31 760 4557894 NP_000230.1 800 8.5e-83 lysozyme C precursor [Homo sapiens]>gi|57114017|ref|NP_001009073.1| lysozyme C precursor [Pan troglodytes]>gi|397474616|ref|XP_003808770.1| PREDICTED: lysozyme C [Pan paniscus]>gi|48428995|sp|P61626.1|LYSC_HUMAN RecName: Full=Lysozyme C; AltName: Full=1,4-beta-N-acetylmuramidase C; Flags: Precursor>gi|48428996|sp|P61628.1|LYSC_PANTR RecName: Full=Lysozyme C; AltName: Full=1,4-beta-N-acetylmuramidase C; Flags: Precursor>gi|54037754|sp|P61627.1|LYSC_PANPA RecName: Full=Lysozyme C; AltName: Full=1,4-beta-N-acetylmuramidase C; Flags: Precursor>gi|307140|gb|AAA59535.1| lysozyme precursor (EC 3.2.1.17) [Homo sapiens]>gi|307142|gb|AAA59536.1| lysozyme precursor (EC 3.2.1.17) [Homo sapiens]>gi|1790941|gb|AAB41209.1| lysozyme c precursor [Pan troglodytes]>gi|1790961|gb|AAB41214.1| lysozyme c precursor [Pan paniscus]>gi|13278744|gb|AAH04147.1| Lysozyme (renal amyloidosis) [Homo sapiens]>gi|119617626|gb|EAW97220.1| lysozyme (renal amyloidosis), isoform CRA_a [Homo sapiens]>gi|119617627|gb|EAW97221.1| lysozyme (renal amyloidosis), isoform CRA_a [Homo sapiens]>gi|119617628|gb|EAW97222.1| lysozyme (renal amyloidosis), isoform CRA_a [Homo sapiens]>gi|123982912|gb|ABM83197.1| lysozyme (renal amyloidosis) [synthetic construct]>gi|123997593|gb|ABM86398.1| lysozyme (renal amyloidosis) [synthetic construct]>gi|189053100|dbj|BAG34722.1| unnamed protein product [Homo sapiens]>gi|226201415|gb|ACO37637.1| lysozyme [Homo sapiens]>gi|649101272|gb|AIC49149.1| LYZ, partial [synthetic construct]>gi|674274715|tpe|CDM98740.1| TPA: lysozyme F1 [Homo sapiens]>gi|674277674|gb|AIL02126.1| c-type lysozyme precursor [Homo sapiens] 37588913 BC004147.2 760 0 Homo sapiens lysozyme (renal amyloidosis), mRNA (cDNA clone MGC:2337 IMAGE:2959387), complete cds K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 P61626 800 3.5e-84 Lysozyme C OS=Homo sapiens GN=LYZ PE=1 SV=1 -- -- GO:0019835//GO:0042742//GO:0006954//GO:0016998//GO:0005975 cytolysis//defense response to bacterium//inflammatory response//cell wall macromolecule catabolic process//carbohydrate metabolic process GO:0003796 lysozyme activity GO:0005615 extracellular space -- -- Cluster-8309.66011 BP_3 10.00 0.79 902 237836773 XP_002367684.1 978 2.3e-103 60S ribosomal protein L8, putative [Toxoplasma gondii ME49]>gi|523574805|gb|EPR61544.1| ribosomal protein RPL8 [Toxoplasma gondii GT1]>gi|527313437|gb|EPT30065.1| ribosomal protein RPL8 [Toxoplasma gondii ME49]>gi|557737203|gb|ESS33177.1| ribosomal protein RPL8 [Toxoplasma gondii VEG]>gi|672264084|gb|KFG37983.1| ribosomal protein RPL8 [Toxoplasma gondii GAB2-2007-GAL-DOM2]>gi|672265952|gb|KFG39483.1| ribosomal protein RPL8 [Toxoplasma gondii FOU]>gi|672274457|gb|KFG46296.1| ribosomal protein RPL8 [Toxoplasma gondii p89]>gi|672297583|gb|KFG61796.1| ribosomal protein RPL8 [Toxoplasma gondii RUB]>gi|672565317|gb|KFH05656.1| ribosomal protein RPL8 [Toxoplasma gondii MAS]>gi|672567320|gb|KFH07276.1| ribosomal protein RPL8 [Toxoplasma gondii VAND]>gi|820698023|tpe|CEL73756.1| TPA: 60S ribosomal protein L8, putative [Toxoplasma gondii VEG] 697079895 XM_009655337.1 892 0 Verticillium dahliae VdLs.17 60S ribosomal protein L2 mRNA K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q75AP7 1089 1.3e-117 60S ribosomal protein L2 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=RPL2 PE=4 SV=1 PF00181//PF03947 Ribosomal Proteins L2, RNA binding domain//Ribosomal Proteins L2, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2309 60s ribosomal protein L2/L8 Cluster-8309.66012 BP_3 24.00 2.65 729 -- -- -- -- -- 768311755 CP010983.1 708 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66017 BP_3 62.01 1.00 3281 642936733 XP_008198558.1 1296 1.1e-139 PREDICTED: suppressor of lurcher protein 1 [Tribolium castaneum] 642936732 XM_008200336.1 331 1.48048e-170 PREDICTED: Tribolium castaneum suppressor of lurcher protein 1 (LOC103314385), mRNA -- -- -- -- Q93212 439 1.1e-41 Suppressor of lurcher protein 1 OS=Caenorhabditis elegans GN=sol-1 PE=1 SV=3 PF03989 DNA gyrase C-terminal domain, beta-propeller GO:0006265 DNA topological change GO:0003677//GO:0005524//GO:0003916 DNA binding//ATP binding//DNA topoisomerase activity GO:0005694 chromosome -- -- Cluster-8309.66018 BP_3 2.00 0.38 546 873231363 CEM08610.1 303 2.6e-25 unnamed protein product [Vitrella brassicaformis CCMP3155] 597569085 KF990036.1 546 0 Prunus kansuensis chloroplast, complete genome K01358 clpP, CLPP ATP-dependent Clp protease, protease subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01358 A0A360 486 6.4e-48 ATP-dependent Clp protease proteolytic subunit OS=Coffea arabica GN=clpP PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0840 ATP-dependent Clp protease, proteolytic subunit Cluster-8309.66019 BP_3 2.00 0.33 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66024 BP_3 320.59 7.23 2428 642914825 XP_008194954.1 1269 1.1e-136 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54316 373 3.6e-34 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66028 BP_3 52.09 4.76 819 642927632 XP_008195342.1 514 1.3e-49 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9BVJ7 315 6.5e-28 Dual specificity protein phosphatase 23 OS=Homo sapiens GN=DUSP23 PE=1 SV=1 PF05706//PF00102//PF00782 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0004721//GO:0008138//GO:0004725 phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.66029 BP_3 3.00 0.45 615 -- -- -- -- -- 768311759 CP010987.1 481 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- PF01914//PF04718 MarC family integral membrane protein//Mitochondrial ATP synthase g subunit GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276//GO:0016021 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.66031 BP_3 4.37 0.46 753 642926052 XP_970129.2 502 3.0e-48 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 175 1.0e-11 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66033 BP_3 44.00 9.94 505 239505103 ACR78697.1 575 6.9e-57 40S ribosomal protein S20 [Rimicaris exoculata] 262401184 FJ774774.1 155 1.48389e-73 Scylla paramamosain 40S ribosomal protein S20 mRNA, partial cds K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P23403 482 1.7e-47 40S ribosomal protein S20 OS=Xenopus laevis GN=rps20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.66040 BP_3 1.00 0.72 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66042 BP_3 15.00 0.45 1900 861594808 KMQ83108.1 146 1.4e-06 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66043 BP_3 7.00 0.67 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66044 BP_3 8.64 0.74 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66050 BP_3 14.01 1.96 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66054 BP_3 2.00 0.38 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66056 BP_3 7.00 0.41 1110 270003540 EEZ99987.1 205 1.2e-13 hypothetical protein TcasGA2_TC002788 [Tribolium castaneum] 642916759 XM_008194282.1 91 1.27802e-37 PREDICTED: Tribolium castaneum SCY1-like protein 2 (LOC661144), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66057 BP_3 9.00 0.80 836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6606 BP_3 15.00 0.60 1498 189234238 XP_001810867.1 215 1.1e-14 PREDICTED: microtubule-associated protein Jupiter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0LXQ1 126 9.8e-06 Translation initiation factor IF-2 OS=Gramella forsetii (strain KT0803) GN=infB PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66060 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66069 BP_3 20.89 0.57 2046 642937584 XP_008199108.1 844 1.8e-87 PREDICTED: fidgetin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PIW4 694 1.8e-71 Fidgetin-like protein 1 OS=Homo sapiens GN=FIGNL1 PE=1 SV=2 PF07728//PF00004//PF03969//PF07724 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//AFG1-like ATPase//AAA domain (Cdc48 subfamily) -- -- GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- KOG0740 AAA+-type ATPase Cluster-8309.66072 BP_3 6.00 1.32 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66073 BP_3 84.00 1.49 3015 593723158 XP_007107776.1 403 3.6e-36 PREDICTED: zinc finger protein 227-like isoform X3 [Physeter catodon] 642931843 XM_008198531.1 217 3.20265e-107 PREDICTED: Tribolium castaneum protein sister of odd and bowel (LOC660734), mRNA K09215 OSR, ODD odd-skipped http://www.genome.jp/dbget-bin/www_bget?ko:K09215 Q6ZR52 393 2.2e-36 Zinc finger protein 493 OS=Homo sapiens GN=ZNF493 PE=2 SV=3 PF13912//PF01363//PF01428//PF13465//PF00096//PF05197//PF07975 C2H2-type zinc finger//FYVE zinc finger//AN1-like Zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//TRIC channel//TFIIH C1-like domain GO:0006281//GO:0015672//GO:0006812 DNA repair//monovalent inorganic cation transport//cation transport GO:0046872//GO:0005261//GO:0008270 metal ion binding//cation channel activity//zinc ion binding GO:0016020 membrane -- -- Cluster-8309.66077 BP_3 5.00 3.34 360 478251907 ENN72345.1 247 5.3e-19 hypothetical protein YQE_10980, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.66078 BP_3 36.00 0.62 3070 642913684 XP_008201117.1 269 1.3e-20 PREDICTED: protein amalgam [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.66082 BP_3 2.00 1.21 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66084 BP_3 3.22 0.47 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66085 BP_3 133.00 4.40 1749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66091 BP_3 40.69 0.51 4113 649572261 NP_001280507.1 1907 2.0e-210 5-hydroxytryptamine receptor 2C-like [Tribolium castaneum]>gi|642922007|ref|XP_008192980.1| PREDICTED: 5-hydroxytryptamine receptor 2C-like [Tribolium castaneum]>gi|270008193|gb|EFA04641.1| hypothetical protein TcasGA2_TC013979 [Tribolium castaneum]>gi|485836761|tpg|DAA64509.1| TPA_inf: CG1056-like serotonin receptor [Tribolium castaneum] 662203355 XM_008476790.1 63 1.7779e-21 PREDICTED: Diaphorina citri 5-hydroxytryptamine receptor 2B-like (LOC103512037), mRNA K04157 HTR2 5-hydroxytryptamine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04157 P24628 506 2.3e-49 D(2) dopamine receptor A OS=Xenopus laevis GN=drd2-a PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.66096 BP_3 6.00 0.57 797 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66097 BP_3 5.00 0.50 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66099 BP_3 3.00 0.53 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66109 BP_3 2.00 1.19 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66117 BP_3 2971.10 224.02 931 478263116 ENN81509.1 304 3.4e-25 hypothetical protein YQE_02038, partial [Dendroctonus ponderosae]>gi|546672296|gb|ERL84223.1| hypothetical protein D910_01601 [Dendroctonus ponderosae]>gi|546675497|gb|ERL86682.1| hypothetical protein D910_04088 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P26967 234 1.8e-18 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.66118 BP_3 10.00 1.67 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66122 BP_3 24.00 19.85 344 403311094 AFR34053.1 450 1.5e-42 NADH dehydrogenase subunit 3 (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 341 3.92092e-177 Scylla paramamosain mitochondrion, complete genome K03880 ND3 NADH-ubiquinone oxidoreductase chain 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03880 P34850 283 1.4e-24 NADH-ubiquinone oxidoreductase chain 3 OS=Anopheles gambiae GN=mt:ND3 PE=3 SV=1 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0006814//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- KOG4662 NADH dehydrogenase subunit 3 and related proteins Cluster-8309.66129 BP_3 99.00 10.19 760 91087377 XP_975644.1 398 3.5e-36 PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum]>gi|642929867|ref|XP_008196006.1| PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum] -- -- -- -- -- K02219 CKS1 cyclin-dependent kinase regulatory subunit CKS1 http://www.genome.jp/dbget-bin/www_bget?ko:K02219 Q91879 322 9.3e-29 Cyclin-dependent kinases regulatory subunit 2 OS=Xenopus laevis GN=cks2 PE=3 SV=1 PF01111 Cyclin-dependent kinase regulatory subunit GO:0045859//GO:0007049 regulation of protein kinase activity//cell cycle GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG3484 Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins Cluster-8309.66130 BP_3 1.00 0.51 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66132 BP_3 3.00 0.46 608 861563745 KMQ81409.1 284 4.6e-23 non-classical export protein, partial [Lasius niger] 631235297 XM_007914380.1 68 4.16167e-25 Togninia minima UCRPA7 putative non-classical export protein mRNA -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.66135 BP_3 4.00 0.31 906 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66137 BP_3 61.81 6.86 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66138 BP_3 92.57 13.23 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66139 BP_3 121.71 14.69 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6614 BP_3 12.88 0.87 1006 752863744 XP_011268239.1 355 4.5e-31 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66144 BP_3 3.00 0.53 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66145 BP_3 3.00 0.37 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66149 BP_3 9.58 0.36 1590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08072//PF05773 BDHCT (NUC031) domain//RWD domain GO:0006260 DNA replication GO:0005524//GO:0003677//GO:0016818//GO:0005515 ATP binding//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//protein binding GO:0005634 nucleus -- -- Cluster-8309.6615 BP_3 143.00 6.51 1351 642936661 XP_008198527.1 1009 8.8e-107 PREDICTED: uncharacterized protein LOC103314375 [Tribolium castaneum]>gi|270014170|gb|EFA10618.1| hypothetical protein TcasGA2_TC012880 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.66151 BP_3 39.67 0.51 4042 780635442 XP_011686539.1 291 4.7e-23 PREDICTED: uncharacterized protein LOC105449216 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66152 BP_3 21.75 0.32 3603 780635442 XP_011686539.1 284 2.7e-22 PREDICTED: uncharacterized protein LOC105449216 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02077 SURF4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.66157 BP_3 7.00 0.51 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66159 BP_3 1.00 0.52 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6616 BP_3 22.21 0.43 2766 642921556 XP_008192422.1 1506 4.2e-164 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- K14616 CUBN cubilin http://www.genome.jp/dbget-bin/www_bget?ko:K14616 Q9TU53 800 1.3e-83 Cubilin OS=Canis familiaris GN=CUBN PE=1 SV=1 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.66163 BP_3 195.97 5.74 1937 91081315 XP_969699.1 1557 3.6e-170 PREDICTED: protein fuzzy homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HZX7 591 1.5e-59 Protein fuzzy homolog OS=Xenopus tropicalis GN=fuz PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6617 BP_3 3338.00 157.69 1312 91081279 XP_976155.1 488 2.2e-46 PREDICTED: vacuolar protein-sorting-associated protein 36 [Tribolium castaneum]>gi|270006083|gb|EFA02531.1| hypothetical protein TcasGA2_TC008236 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66171 BP_3 2.00 0.96 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66173 BP_3 38.17 0.48 4089 642915450 XP_008190622.1 3369 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MYCBP2 [Tribolium castaneum] 149275329 AC205539.1 48 3.85299e-13 Tribolium castaneum 3 BAC MEDEA BAC 22J23 complete sequence K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 O75592 1905 1.4e-211 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3 PF01179//PF01552 Copper amine oxidase, enzyme domain//Picornavirus 2B protein GO:0055114//GO:0009308//GO:0006144//GO:0018144//GO:0006508 oxidation-reduction process//amine metabolic process//purine nucleobase metabolic process//RNA-protein covalent cross-linking//proteolysis GO:0005198//GO:0016740//GO:0016787//GO:0048038//GO:0016779//GO:0008131//GO:0008233//GO:0000166//GO:0008234//GO:0005507//GO:0003968 structural molecule activity//transferase activity//hydrolase activity//quinone binding//nucleotidyltransferase activity//primary amine oxidase activity//peptidase activity//nucleotide binding//cysteine-type peptidase activity//copper ion binding//RNA-directed RNA polymerase activity GO:0019012//GO:0031379 virion//RNA-directed RNA polymerase complex KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.66180 BP_3 28.00 5.46 539 540849065 AGV15438.1 149 1.8e-07 metallothionein 2 [Portunus trituberculatus] 540849064 KC203334.1 267 8.71278e-136 Portunus trituberculatus metallothionein 2 (MT2) mRNA, complete cds -- -- -- -- P02805 153 2.6e-09 Metallothionein-1 OS=Scylla serrata PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66181 BP_3 2.58 3.76 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66182 BP_3 37.82 3.02 895 270014106 EFA10554.1 412 9.8e-38 hypothetical protein TcasGA2_TC012810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66183 BP_3 1.00 1.69 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66184 BP_3 9.00 0.85 802 642928077 XP_008200146.1 307 1.3e-25 PREDICTED: homer protein homolog 2 [Tribolium castaneum]>gi|270010897|gb|EFA07345.1| hypothetical protein TcasGA2_TC015941 [Tribolium castaneum] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 O88801 177 6.4e-12 Homer protein homolog 2 OS=Rattus norvegicus GN=Homer2 PE=1 SV=1 PF13851//PF06810//PF16716//PF07544//PF04977 Growth-arrest specific micro-tubule binding//Phage minor structural protein GP20//Bone marrow stromal antigen 2//RNA polymerase II transcription mediator complex subunit 9//Septum formation initiator GO:0006357//GO:0007049//GO:0051607//GO:0048870 regulation of transcription from RNA polymerase II promoter//cell cycle//defense response to virus//cell motility GO:0001104//GO:0005198 RNA polymerase II transcription cofactor activity//structural molecule activity GO:0016592//GO:0031514 mediator complex//motile cilium -- -- Cluster-8309.66189 BP_3 9.00 0.54 1089 -- -- -- -- -- 768311755 CP010983.1 1059 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66191 BP_3 6.99 0.47 1003 642935087 XP_008197879.1 357 2.6e-31 PREDICTED: protein scarlet isoform X1 [Tribolium castaneum]>gi|744677513|gb|AJD07060.1| scarlet [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45843 264 6.5e-22 Protein scarlet OS=Drosophila melanogaster GN=st PE=1 SV=3 PF00005//PF01695//PF03193//PF01926//PF02367//PF13304 ABC transporter//IstB-like ATP binding protein//Protein of unknown function, DUF258//50S ribosome-binding GTPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//AAA domain, putative AbiEii toxin, Type IV TA system GO:0002949 tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0005525//GO:0005524//GO:0016887 GTPase activity//GTP binding//ATP binding//ATPase activity -- -- -- -- Cluster-8309.66195 BP_3 8.54 0.37 1391 795018296 XP_011859159.1 338 5.8e-29 PREDICTED: putative nuclease HARBI1 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66198 BP_3 9.00 0.31 1694 641681040 XP_008189310.1 208 8.4e-14 PREDICTED: tigger transposable element-derived protein 4-like [Acyrthosiphon pisum] 462341982 APGK01035868.1 49 4.38639e-14 Dendroctonus ponderosae Seq01035878, whole genome shotgun sequence -- -- -- -- Q8BUZ3 151 1.4e-08 Tigger transposable element-derived protein 4 OS=Mus musculus GN=Tigd4 PE=2 SV=1 PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.66203 BP_3 2.00 6.41 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66205 BP_3 41.00 0.83 2679 642925918 XP_008194696.1 1078 1.7e-114 PREDICTED: ras-like protein family member 10B, partial [Tribolium castaneum] -- -- -- -- -- K07851 RASL10B Ras-like protein family member 10B http://www.genome.jp/dbget-bin/www_bget?ko:K07851 Q96S79 416 4.1e-39 Ras-like protein family member 10B OS=Homo sapiens GN=RASL10B PE=2 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.66208 BP_3 2.00 0.52 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66210 BP_3 1.00 0.42 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66211 BP_3 2.00 0.71 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66213 BP_3 4.73 0.51 740 478258102 ENN78240.1 175 2.4e-10 hypothetical protein YQE_05391, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.66215 BP_3 17.00 0.43 2218 321460362 EFX71405.1 2165 1.3e-240 hypothetical protein DAPPUDRAFT_327246 [Daphnia pulex] 742099227 XM_010870414.1 209 6.57362e-103 PREDICTED: Esox lucius acyl-CoA dehydrogenase, very long chain (acadvl), mRNA K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 P48818 1882 3.5e-209 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=ACADVL PE=2 SV=3 PF02771//PF02770//PF00441//PF03839 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Translocation protein Sec62 GO:0008152//GO:0006118//GO:0015031//GO:0055114 metabolic process//obsolete electron transport//protein transport//oxidation-reduction process GO:0003995//GO:0008565//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//protein transporter activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021 integral component of membrane KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.66218 BP_3 2.00 1.01 385 189237223 XP_969624.2 271 9.3e-22 PREDICTED: 45 kDa calcium-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6622 BP_3 29.00 0.54 2903 270004811 EFA01259.1 1402 5.1e-152 hypothetical protein TcasGA2_TC002524 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q11082 278 4.5e-23 Probable G-protein coupled receptor B0563.6 OS=Caenorhabditis elegans GN=B0563.6 PE=3 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.66222 BP_3 1.00 0.55 377 270011141 EFA07589.1 138 2.4e-06 hypothetical protein TcasGA2_TC030048, partial [Tribolium castaneum] 392303560 JX102593.1 267 5.9369e-136 Scylla paramamosain microsatellite Spm22 sequence -- -- -- -- -- -- -- -- PF02285 Cytochrome oxidase c subunit VIII GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.66225 BP_3 5.00 0.41 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66228 BP_3 14.00 0.68 1291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6623 BP_3 6.00 0.33 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66230 BP_3 2.00 0.69 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66231 BP_3 8.00 0.45 1141 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66237 BP_3 27.12 1.03 1555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66238 BP_3 29.68 2.34 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66245 BP_3 1.00 3.49 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66246 BP_3 7.00 2.46 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66247 BP_3 21.11 0.51 2280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66252 BP_3 1.00 0.59 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66257 BP_3 1.00 0.99 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66258 BP_3 5.00 0.54 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6626 BP_3 25.69 1.21 1318 546679463 ERL89927.1 698 9.9e-71 hypothetical protein D910_07286 [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 O95425 451 1.8e-43 Supervillin OS=Homo sapiens GN=SVIL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66261 BP_3 17.00 4.42 477 262401367 ACY66586.1 754 1.1e-77 putative ribosomal protein S23e [Scylla paramamosain] 262401366 FJ774865.1 474 0 Scylla paramamosain putative ribosomal protein S23e mRNA, complete cds K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q86FP7 731 2.2e-76 40S ribosomal protein S23 OS=Dermacentor variabilis GN=RpS23 PE=2 SV=1 PF00164//PF09445 Ribosomal protein S12/S23//RNA cap guanine-N2 methyltransferase GO:0042254//GO:0001510//GO:0009452//GO:0006412 ribosome biogenesis//RNA methylation//7-methylguanosine RNA capping//translation GO:0008168//GO:0003735 methyltransferase activity//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1749 40S ribosomal protein S23 Cluster-8309.66263 BP_3 8.00 0.43 1185 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66264 BP_3 4.00 1.49 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66266 BP_3 8.00 0.35 1407 768449833 XP_011567021.1 645 1.5e-64 PREDICTED: fumarate reductase-like [Plutella xylostella] 768311759 CP010987.1 1395 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- P21375 595 3.8e-60 Fumarate reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OSM1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2403 Succinate dehydrogenase, flavoprotein subunit Cluster-8309.66268 BP_3 2.00 0.55 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66269 BP_3 16.98 0.58 1704 817186438 XP_012287721.1 392 3.9e-35 PREDICTED: multiple epidermal growth factor-like domains protein 6 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66276 BP_3 2.00 0.95 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66277 BP_3 4.00 0.80 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66278 BP_3 3.00 0.67 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66279 BP_3 2.00 0.33 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66280 BP_3 2.00 0.41 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66285 BP_3 5.00 0.37 946 270015672 EFA12120.1 1143 1.8e-122 hypothetical protein TcasGA2_TC002266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1003 1.3e-107 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF12285 Protein of unknown function (DUF3621) -- -- GO:0004252//GO:0070008 serine-type endopeptidase activity//serine-type exopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.66289 BP_3 15.00 0.56 1594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08086 Ergtoxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.66290 BP_3 2.00 0.45 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66291 BP_3 17.55 0.77 1388 270012638 EFA09086.1 272 2.6e-21 hypothetical protein TcasGA2_TC006806 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04362//PF07527 Bacterial Fe(2+) trafficking//Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0005506//GO:0003677 iron ion binding//DNA binding -- -- -- -- Cluster-8309.66293 BP_3 8.00 0.58 958 126697456 ABO26685.1 541 1.2e-52 ribosomal protein l17 [Haliotis discus discus] 697076657 XM_009654213.1 818 0 Verticillium dahliae VdLs.17 60S ribosomal protein L17 mRNA K02880 RP-L17e, RPL17 large subunit ribosomal protein L17e http://www.genome.jp/dbget-bin/www_bget?ko:K02880 Q9HE25 818 3.6e-86 60S ribosomal protein L17 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-17 PE=3 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3353 60S ribosomal protein L22 Cluster-8309.66295 BP_3 7.00 0.67 793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66297 BP_3 7.00 0.66 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66298 BP_3 2.38 0.64 470 557745704 AHA33382.1 427 9.3e-40 odorant-binding protein 1 [Batocera horsfieldi] 557745703 KC461118.1 242 5.95534e-122 Batocera horsfieldi odorant-binding protein 1 (obp1) mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.66299 BP_3 11.64 3.70 443 557745704 AHA33382.1 522 8.5e-51 odorant-binding protein 1 [Batocera horsfieldi] 557745703 KC461118.1 294 6.92736e-151 Batocera horsfieldi odorant-binding protein 1 (obp1) mRNA, complete cds -- -- -- -- A7UR17 127 2.2e-06 General odorant-binding protein 72 (Fragment) OS=Anopheles gambiae GN=Obp72 PE=3 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.6630 BP_3 226.82 4.63 2655 642927615 XP_008195335.1 2050 3.4e-227 PREDICTED: ribosomal protein S6 kinase delta-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R2S1 381 4.7e-35 Ribosomal protein S6 kinase-like 1 OS=Mus musculus GN=Rps6kl1 PE=1 SV=1 PF00787//PF00069//PF07714//PF13374//PF13181//PF00515//PF13414 PX domain//Protein kinase domain//Protein tyrosine kinase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515//GO:0035091 ATP binding//protein kinase activity//protein binding//phosphatidylinositol binding -- -- -- -- Cluster-8309.66300 BP_3 5.98 0.74 680 557745704 AHA33382.1 759 4.3e-78 odorant-binding protein 1 [Batocera horsfieldi] 557745703 KC461118.1 429 0 Batocera horsfieldi odorant-binding protein 1 (obp1) mRNA, complete cds -- -- -- -- A7UR17 172 2.1e-11 General odorant-binding protein 72 (Fragment) OS=Anopheles gambiae GN=Obp72 PE=3 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.66303 BP_3 10.00 0.44 1378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05280 Flagellar transcriptional activator (FlhC) GO:0045893//GO:1902208 positive regulation of transcription, DNA-templated//regulation of bacterial-type flagellum assembly GO:0003677 DNA binding -- -- -- -- Cluster-8309.66305 BP_3 5.00 0.36 966 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02126 Phosphotriesterase family GO:0009056 catabolic process GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.66306 BP_3 12.63 0.73 1125 478257733 ENN77876.1 527 5.7e-51 hypothetical protein YQE_05554, partial [Dendroctonus ponderosae]>gi|546687636|gb|ERL96238.1| hypothetical protein D910_01526 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66307 BP_3 13.92 0.31 2489 478257733 ENN77876.1 698 1.9e-70 hypothetical protein YQE_05554, partial [Dendroctonus ponderosae]>gi|546687636|gb|ERL96238.1| hypothetical protein D910_01526 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03172//PF04758 Sp100 domain//Ribosomal protein S30 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005634//GO:0005840//GO:0005622 nucleus//ribosome//intracellular -- -- Cluster-8309.6631 BP_3 20.85 0.42 2711 642927615 XP_008195335.1 1805 8.8e-199 PREDICTED: ribosomal protein S6 kinase delta-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S38 355 5.0e-32 Ribosomal protein S6 kinase delta-1 OS=Homo sapiens GN=RPS6KC1 PE=1 SV=2 PF13414//PF07714//PF13374//PF13181//PF00515//PF00787//PF00069 TPR repeat//Protein tyrosine kinase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//PX domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515//GO:0035091 ATP binding//protein kinase activity//protein binding//phosphatidylinositol binding -- -- -- -- Cluster-8309.66318 BP_3 6.57 0.87 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00105 Zinc finger, C4 type (two domains) GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.66328 BP_3 4.00 0.79 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66330 BP_3 12.70 0.45 1661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66344 BP_3 36.00 0.94 2135 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66349 BP_3 52.00 1.13 2512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66351 BP_3 167.00 8.06 1290 817076284 XP_012260406.1 610 1.5e-60 PREDICTED: phospholipase A2 [Athalia rosae] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 A7LCJ2 220 1.1e-16 Phospholipase A2 OS=Urticina crassicornis PE=1 SV=1 PF01396 Topoisomerase DNA binding C4 zinc finger GO:0006265 DNA topological change GO:0003916//GO:0003677 DNA topoisomerase activity//DNA binding GO:0005694 chromosome KOG4087 Phospholipase A2 Cluster-8309.66355 BP_3 4.00 0.51 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66360 BP_3 24.75 0.33 3879 91092716 XP_972399.1 1644 5.9e-180 PREDICTED: lachesin isoform X1 [Tribolium castaneum]>gi|642911406|ref|XP_008199409.1| PREDICTED: lachesin isoform X1 [Tribolium castaneum] 807034033 XM_012303667.1 42 7.90813e-10 PREDICTED: Ceratitis capitata peroxidasin homolog (LOC101454583), mRNA -- -- -- -- Q26474 373 5.8e-34 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.66362 BP_3 23.61 0.79 1741 91085917 XP_969488.1 745 4.6e-76 PREDICTED: zinc transporter ZIP3 [Tribolium castaneum]>gi|270009956|gb|EFA06404.1| hypothetical protein TcasGA2_TC009283 [Tribolium castaneum] -- -- -- -- -- K14709 SLC39A1_2_3, ZIP1_2_3 solute carrier family 39 (zinc transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14709 P59889 242 4.0e-19 Zinc transporter ZIP1 OS=Danio rerio GN=slc39a1 PE=2 SV=1 PF00509//PF02535 Haemagglutinin//ZIP Zinc transporter GO:0055085//GO:0007165//GO:0030001//GO:0019064 transmembrane transport//signal transduction//metal ion transport//fusion of virus membrane with host plasma membrane GO:0046873//GO:0046789 metal ion transmembrane transporter activity//host cell surface receptor binding GO:0016020//GO:0009986//GO:0019031 membrane//cell surface//viral envelope KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.66365 BP_3 28.79 3.92 646 642925964 XP_008194711.1 169 1.1e-09 PREDICTED: uncharacterized protein LOC103313388 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66370 BP_3 2.00 2.64 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66372 BP_3 12.96 0.53 1479 546681874 ERL91883.1 471 2.3e-44 hypothetical protein D910_09207 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02424//PF04827//PF01609 ApbE family//Plant transposon protein//Transposase DDE domain GO:0006313//GO:0017013 transposition, DNA-mediated//protein flavinylation GO:0004803//GO:0016788//GO:0003677 transposase activity//hydrolase activity, acting on ester bonds//DNA binding -- -- -- -- Cluster-8309.66374 BP_3 51.56 2.04 1508 821471975 XP_012399763.1 380 8.5e-34 PREDICTED: zinc finger protein 658B-like [Sarcophilus harrisii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5JVG2 353 4.7e-32 Zinc finger protein 484 OS=Homo sapiens GN=ZNF484 PE=1 SV=1 PF13465//PF00096//PF13912//PF07776//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.66378 BP_3 5093.00 25603.55 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66379 BP_3 6.00 1.38 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66380 BP_3 187.00 16.93 824 478259936 ENN79738.1 166 3.0e-09 hypothetical protein YQE_03794, partial [Dendroctonus ponderosae]>gi|546674731|gb|ERL86040.1| hypothetical protein D910_03454 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66381 BP_3 700.79 156.79 507 91091646 XP_970895.1 265 6.2e-21 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000889|gb|EEZ97336.1| hypothetical protein TcasGA2_TC011148 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 191 9.7e-14 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF02949//PF00379 7tm Odorant receptor//Insect cuticle protein GO:0007608//GO:0007187 sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0042302//GO:0005549//GO:0004984 structural constituent of cuticle//odorant binding//olfactory receptor activity GO:0016020 membrane -- -- Cluster-8309.66382 BP_3 3.46 0.42 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66383 BP_3 24.83 0.57 2387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66386 BP_3 2.00 1.96 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66393 BP_3 79.72 2.24 2010 642922086 XP_008193011.1 301 1.6e-24 PREDICTED: cuticle protein 21-like [Tribolium castaneum]>gi|270007255|gb|EFA03703.1| hypothetical protein TcasGA2_TC013808 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81225 186 1.5e-12 Cuticle protein 21 OS=Locusta migratoria GN=ACP21 PE=1 SV=1 PF05417//PF00379 Hepatitis E cysteine protease//Insect cuticle protein GO:0019082//GO:0016032 viral protein processing//viral process GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.66394 BP_3 7.00 0.34 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66396 BP_3 1050.00 151.39 626 478259935 ENN79737.1 155 4.3e-08 hypothetical protein YQE_03793, partial [Dendroctonus ponderosae]>gi|546674730|gb|ERL86039.1| hypothetical protein D910_03453 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6640 BP_3 3.00 33.91 240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66401 BP_3 6.00 1.15 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66402 BP_3 14.00 0.99 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66410 BP_3 5.00 0.34 1004 795010007 XP_011864749.1 198 7.2e-13 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66411 BP_3 287.00 72.99 481 478255481 ENN75698.1 241 3.5e-18 hypothetical protein YQE_07659, partial [Dendroctonus ponderosae]>gi|546676737|gb|ERL87693.1| hypothetical protein D910_05083 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P11733 178 2.9e-12 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 PF00379//PF01059 Insect cuticle protein//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0055114//GO:0006120 oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.66412 BP_3 3.79 0.33 848 91091644 XP_970770.1 376 1.4e-33 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000890|gb|EEZ97337.1| hypothetical protein TcasGA2_TC011149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 217 1.6e-16 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00366//PF00379 Ribosomal protein S17//Insect cuticle protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0042302 structural constituent of ribosome//structural constituent of cuticle GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.66415 BP_3 7.00 1.15 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66422 BP_3 1.00 0.31 446 156386528 XP_001633964.1 245 1.1e-18 predicted protein [Nematostella vectensis]>gi|156221041|gb|EDO41901.1| predicted protein, partial [Nematostella vectensis] 697090328 XM_009659775.1 440 0 Verticillium dahliae VdLs.17 eukaryotic translation initiation factor 3 subunit 8 partial mRNA -- -- -- -- Q7SBD4 602 1.9e-61 Eukaryotic translation initiation factor 3 subunit C OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=nip-1 PE=3 SV=1 PF05470//PF08655 Eukaryotic translation initiation factor 3 subunit 8 N-terminus//DASH complex subunit Ask1 GO:0008608//GO:0006413//GO:0006446 attachment of spindle microtubules to kinetochore//translational initiation//regulation of translational initiation GO:0031369//GO:0003743 translation initiation factor binding//translation initiation factor activity GO:0042729//GO:0005840//GO:0005852//GO:0072686 DASH complex//ribosome//eukaryotic translation initiation factor 3 complex//mitotic spindle KOG1076 Translation initiation factor 3, subunit c (eIF-3c) Cluster-8309.66423 BP_3 2.00 11.08 260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66426 BP_3 26.15 1.03 1515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66428 BP_3 47.19 0.39 6078 665788269 XP_008559724.1 754 1.5e-76 PREDICTED: uncharacterized protein LOC103579935 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03193//PF08398//PF01637//PF00931//PF00770//PF02902//PF13304//PF01628 Protein of unknown function, DUF258//Parvovirus coat protein VP1//Archaeal ATPase//NB-ARC domain//Adenovirus endoprotease//Ulp1 protease family, C-terminal catalytic domain//AAA domain, putative AbiEii toxin, Type IV TA system//HrcA protein C terminal domain GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0005524//GO:0003677//GO:0043531//GO:0005198//GO:0003924//GO:0008234//GO:0005525//GO:0004197 ATP binding//DNA binding//ADP binding//structural molecule activity//GTPase activity//cysteine-type peptidase activity//GTP binding//cysteine-type endopeptidase activity GO:0019028 viral capsid -- -- Cluster-8309.66431 BP_3 23.05 0.33 3618 861615769 KMQ86193.1 970 7.8e-102 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P04146 802 9.7e-84 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF00665//PF02155 Integrase core domain//Glucocorticoid receptor GO:0007165//GO:0015074//GO:0042921//GO:0043402//GO:0006355 signal transduction//DNA integration//glucocorticoid receptor signaling pathway//glucocorticoid mediated signaling pathway//regulation of transcription, DNA-templated GO:0003677//GO:0004883//GO:0005496 DNA binding//glucocorticoid receptor activity//steroid binding GO:0005634 nucleus -- -- Cluster-8309.66433 BP_3 10.00 0.88 841 557000363 XP_006002966.1 360 9.8e-32 PREDICTED: 60S ribosomal protein L31 isoform X1 [Latimeria chalumnae] 768311752 CP010980.1 600 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 Q757D7 387 3.0e-36 60S ribosomal protein L31 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=RPL31 PE=3 SV=2 PF01198 Ribosomal protein L31e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0893 60S ribosomal protein L31 Cluster-8309.66434 BP_3 11.13 0.46 1450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66436 BP_3 15.00 1.14 927 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66438 BP_3 7.00 1.31 550 817063750 XP_012253590.1 204 7.9e-14 PREDICTED: excitatory amino acid transporter isoform X3 [Athalia rosae] -- -- -- -- -- K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 P51906 162 2.4e-10 Excitatory amino acid transporter 3 OS=Mus musculus GN=Slc1a1 PE=1 SV=2 PF00375 Sodium:dicarboxylate symporter family GO:0006835//GO:0006812//GO:0006820 dicarboxylic acid transport//cation transport//anion transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.66439 BP_3 1021.37 104.02 765 270006762 EFA03210.1 351 9.9e-31 hypothetical protein TcasGA2_TC013130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 260 1.4e-21 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66442 BP_3 3.00 0.43 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66444 BP_3 4.00 0.58 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6645 BP_3 239.07 4.20 3033 478250964 ENN71448.1 2669 6.4e-299 hypothetical protein YQE_11867, partial [Dendroctonus ponderosae] 572265044 XM_006610604.1 55 3.65957e-17 PREDICTED: Apis dorsata glucose dehydrogenase [FAD, quinone]-like (LOC102678750), transcript variant X2, mRNA -- -- -- -- P18172 1129 9.9e-122 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF07992//PF05834//PF00732//PF01266 GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.66451 BP_3 15.00 0.71 1314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66453 BP_3 47.00 3.27 985 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66457 BP_3 23.42 0.43 2906 546685576 ERL95063.1 2567 4.1e-287 hypothetical protein D910_12333 [Dendroctonus ponderosae] 564241862 XM_006277680.1 37 3.55443e-07 PREDICTED: Alligator mississippiensis REV1, polymerase (DNA directed) (REV1), transcript variant X3, mRNA K03515 REV1 DNA repair protein REV1 http://www.genome.jp/dbget-bin/www_bget?ko:K03515 Q4KWZ7 1026 8.3e-110 DNA repair protein REV1 OS=Gallus gallus GN=REV1 PE=2 SV=1 PF00817//PF11799//PF00961 impB/mucB/samB family//impB/mucB/samB family C-terminal domain//LAGLIDADG endonuclease GO:0006281 DNA repair GO:0004519//GO:0003684 endonuclease activity//damaged DNA binding -- -- KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase Cluster-8309.66459 BP_3 10.00 0.87 843 646720263 KDR22070.1 138 5.4e-06 hypothetical protein L798_02924, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66462 BP_3 8.00 0.49 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66463 BP_3 25.00 0.56 2459 642923542 XP_008193552.1 1258 2.1e-135 PREDICTED: probable G-protein coupled receptor Mth-like 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY15 168 2.2e-10 Adhesion G protein-coupled receptor E3 OS=Homo sapiens GN=ADGRE3 PE=2 SV=2 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.66464 BP_3 10.71 0.36 1733 642934524 XP_008197698.1 825 2.4e-85 PREDICTED: uncharacterized protein LOC100141936 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 G3V9H8 450 3.1e-43 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Rattus norvegicus GN=Ret PE=1 SV=1 PF07714//PF00069//PF06293//PF03785 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Peptidase family C25, C terminal ig-like domain GO:0006468//GO:0006508 protein phosphorylation//proteolysis GO:0008233//GO:0004672//GO:0016773//GO:0005524 peptidase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.66465 BP_3 25.79 0.62 2290 642926444 XP_008191961.1 1823 6.1e-201 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009090|gb|EFA05538.1| hypothetical protein TcasGA2_TC015725 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 1018 5.5e-109 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF00732//PF05834//PF07992//PF01266 GMC oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase GO:0044710//GO:0016117//GO:0055114 single-organism metabolic process//carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.66466 BP_3 19.00 12.08 364 262401442 ACY66623.1 489 4.6e-47 ribosomal protein L44e [Scylla paramamosain] 262401441 FJ774903.1 364 0 Scylla paramamosain ribosomal protein L44e mRNA, complete cds K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q9NB33 375 3.2e-35 60S ribosomal protein L44 OS=Ochlerotatus triseriatus GN=RpL44 PE=3 SV=3 PF00935 Ribosomal protein L44 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3464 60S ribosomal protein L44 Cluster-8309.66467 BP_3 11.00 1.36 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66470 BP_3 3.00 0.49 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66471 BP_3 7.00 0.67 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66472 BP_3 6.00 0.50 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66473 BP_3 3.00 0.57 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66474 BP_3 1.00 0.70 356 634850969 XP_007940051.1 284 2.7e-23 PREDICTED: nucleoside diphosphate kinase B [Orycteropus afer afer] 697080936 XM_009655692.1 220 7.47068e-110 Verticillium dahliae VdLs.17 nucleoside diphosphate kinase partial mRNA K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q7Z8P9 314 3.7e-28 Nucleoside diphosphate kinase OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=ndk1 PE=3 SV=1 PF00334 Nucleoside diphosphate kinase GO:0006165//GO:0006206//GO:0006241//GO:0006183//GO:0006228//GO:0006144 nucleoside diphosphate phosphorylation//pyrimidine nucleobase metabolic process//CTP biosynthetic process//GTP biosynthetic process//UTP biosynthetic process//purine nucleobase metabolic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.66479 BP_3 4.00 0.38 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66480 BP_3 10.00 0.51 1242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66481 BP_3 1.00 1.27 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66483 BP_3 5.00 1.22 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66485 BP_3 11.00 0.57 1229 861594808 KMQ83108.1 371 7.6e-33 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404//PF00126//PF01325//PF01047//PF01371//PF01418 AsnC-type helix-turn-helix domain//Bacterial regulatory helix-turn-helix protein, lysR family//Iron dependent repressor, N-terminal DNA binding domain//MarR family//Trp repressor protein//Helix-turn-helix domain, rpiR family GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular -- -- Cluster-8309.66488 BP_3 5.00 0.36 965 546673251 ERL84892.1 402 1.5e-36 hypothetical protein D910_02315, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66489 BP_3 17.00 1.37 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09749 Uncharacterised conserved protein GO:0034477 U6 snRNA 3'-end processing GO:0004518 nuclease activity -- -- -- -- Cluster-8309.66490 BP_3 7.54 1.00 655 631250148 AHZ13215.1 225 3.4e-16 multicopper oxidase related protein, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66492 BP_3 43.91 0.68 3413 642917922 XP_008200616.1 1570 2.0e-171 PREDICTED: probable cytochrome P450 303a1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q9V399 1053 7.2e-113 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.66495 BP_3 229.99 2.66 4460 546683810 ERL93563.1 3045 0.0e+00 hypothetical protein D910_10852 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1694 4.4e-187 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00005//PF03193//PF01637//PF02367//PF00004//PF00437//PF00664//PF01926//PF13304 ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006810//GO:0055085//GO:0002949 transport//transmembrane transport//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.66496 BP_3 9.00 1.31 624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66497 BP_3 2.00 0.54 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66501 BP_3 3.00 0.44 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66505 BP_3 19.00 2.73 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66508 BP_3 289.48 11.78 1476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66511 BP_3 17.00 0.61 1638 270000952 EEZ97399.1 183 6.4e-11 hypothetical protein TcasGA2_TC011226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.66513 BP_3 15.19 0.52 1688 642913126 XP_008201403.1 1632 6.3e-179 PREDICTED: neurotrimin isoform X3 [Tribolium castaneum] 768439803 XM_011563251.1 238 3.76715e-119 PREDICTED: Plutella xylostella lachesin-like (LOC105391717), transcript variant X2, mRNA -- -- -- -- Q99PJ0 343 7.6e-31 Neurotrimin OS=Mus musculus GN=Ntm PE=2 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.66517 BP_3 4.00 0.35 838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04644 Motilin/ghrelin GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.66518 BP_3 69.60 0.93 3882 642914122 XP_008201553.1 4538 0.0e+00 PREDICTED: cadherin-23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58365 1263 3.7e-137 Cadherin-23 OS=Rattus norvegicus GN=Cdh23 PE=2 SV=1 PF00028//PF08264 Cadherin domain//Anticodon-binding domain of tRNA GO:0006418//GO:0007156 tRNA aminoacylation for protein translation//homophilic cell adhesion via plasma membrane adhesion molecules GO:0000166//GO:0005509 nucleotide binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.6652 BP_3 5.48 0.49 833 795019207 XP_011859498.1 214 8.3e-15 PREDICTED: uncharacterized protein LOC105556990 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66520 BP_3 2.00 0.59 454 803252926 XP_011986416.1 297 1.1e-24 PREDICTED: B-cell antigen receptor complex-associated protein beta chain isoform X2 [Ovis aries musimon] 12804232 BC002975.1 454 0 Homo sapiens CD79b molecule, immunoglobulin-associated beta, mRNA (cDNA clone MGC:2173 IMAGE:3542354), complete cds K06507 CD79B, IGB CD79B antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06507 P40259 297 4.4e-26 B-cell antigen receptor complex-associated protein beta chain OS=Homo sapiens GN=CD79B PE=1 SV=1 PF02189 Immunoreceptor tyrosine-based activation motif GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.66521 BP_3 12.10 0.45 1588 270016830 EFA13276.1 1153 2.1e-123 hypothetical protein TcasGA2_TC016027 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT43 382 2.1e-35 Transposon Tf2-8 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-8 PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.66525 BP_3 8.00 0.51 1044 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12235//PF02178 Fragile X-related 1 protein core C terminal//AT hook motif -- -- GO:0003723//GO:0003677 RNA binding//DNA binding -- -- -- -- Cluster-8309.66526 BP_3 7.23 0.31 1429 270011530 EFA07978.1 300 1.5e-24 hypothetical protein TcasGA2_TC005560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66531 BP_3 2.00 0.67 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66536 BP_3 2.00 0.32 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66540 BP_3 2.00 0.73 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66543 BP_3 2.00 0.47 497 -- -- -- -- -- 759064461 XR_894375.1 74 1.55463e-28 PREDICTED: Cerapachys biroi uncharacterized LOC105281821 (LOC105281821), ncRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66544 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66546 BP_3 132.49 6.06 1346 642923040 XP_973485.2 1107 3.8e-118 PREDICTED: transmembrane protein 164 [Tribolium castaneum]>gi|642923042|ref|XP_008200506.1| PREDICTED: transmembrane protein 164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PHN7 483 3.5e-47 Transmembrane protein 164 OS=Mus musculus GN=Tmem164 PE=2 SV=1 PF14987 NADH dehydrogenase 1 alpha subcomplex subunit 3 -- -- -- -- GO:0005743//GO:0005747 mitochondrial inner membrane//mitochondrial respiratory chain complex I -- -- Cluster-8309.66549 BP_3 34.19 1.74 1236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01771 Herpesvirus alkaline exonuclease -- -- GO:0004527//GO:0003677 exonuclease activity//DNA binding -- -- -- -- Cluster-8309.66550 BP_3 15.00 0.44 1950 -- -- -- -- -- 768311752 CP010980.1 873 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66551 BP_3 511.01 10.83 2567 642919530 XP_008191912.1 320 1.3e-26 PREDICTED: uncharacterized protein LOC103312623 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V7U0 180 9.2e-12 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.66555 BP_3 2.00 6.41 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66557 BP_3 1239.57 77.37 1064 270006762 EFA03210.1 351 1.4e-30 hypothetical protein TcasGA2_TC013130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 260 2.0e-21 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF04566 RNA polymerase Rpb2, domain 4 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.66558 BP_3 9.00 0.41 1352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10440 Ubiquitin-binding WIYLD domain GO:0006479//GO:0006554 protein methylation//lysine catabolic process GO:0018024 histone-lysine N-methyltransferase activity -- -- -- -- Cluster-8309.66559 BP_3 19.99 1.10 1167 642937330 XP_966361.3 762 3.3e-78 PREDICTED: serine proteinase stubble, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 270 1.5e-22 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66566 BP_3 3.00 0.72 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66568 BP_3 8.00 0.53 1023 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66569 BP_3 2.00 1.61 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66574 BP_3 12.00 0.61 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66575 BP_3 7.00 2.04 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66577 BP_3 17.00 2.24 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66578 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66579 BP_3 1325.33 57.43 1404 646713613 KDR17904.1 1741 1.2e-191 Actin, clone 403 [Zootermopsis nevadensis] 558184753 XM_006128029.1 341 1.72488e-176 PREDICTED: Pelodiscus sinensis actin, cytoplasmic type 5-like (LOC102458214), mRNA K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P41340 1733 4.2e-192 Actin-3 OS=Limulus polyphemus PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.66581 BP_3 418.00 12.49 1905 642936477 XP_008198452.1 1965 1.7e-217 PREDICTED: uncharacterized protein LOC656542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66583 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66584 BP_3 1.00 0.33 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66585 BP_3 14.00 0.66 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66587 BP_3 53.71 1.87 1674 546682026 ERL92022.1 1123 6.6e-120 hypothetical protein D910_09344, partial [Dendroctonus ponderosae] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46107 694 1.5e-71 Lipase 1 OS=Drosophila melanogaster GN=Lip1 PE=2 SV=2 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.66590 BP_3 11.00 1.27 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66591 BP_3 12.00 2.55 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66592 BP_3 8.83 0.64 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66593 BP_3 14.00 2.09 614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66596 BP_3 37.39 1.68 1362 189234553 XP_973928.2 509 8.4e-49 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V9A8 291 6.6e-25 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66597 BP_3 2.00 0.32 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66599 BP_3 1.00 0.40 412 642922507 XP_008193202.1 237 8.8e-18 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 175 5.6e-12 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF12009//PF00632 Telomerase ribonucleoprotein complex - RNA binding domain//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0006278 protein ubiquitination//RNA-dependent DNA replication GO:0004842//GO:0003964 ubiquitin-protein transferase activity//RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.66616 BP_3 67.08 2.01 1902 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66618 BP_3 42.34 2.42 1136 558231171 XP_006139245.1 402 1.8e-36 PREDICTED: uncharacterized protein LOC102453386 [Pelodiscus sinensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9XSR1 381 2.0e-35 Zinc finger protein 252 OS=Canis familiaris GN=ZNF252 PE=2 SV=1 PF00628//PF00096//PF13465 PHD-finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.6662 BP_3 73.00 2.73 1580 642923793 XP_008193885.1 720 3.3e-73 PREDICTED: uncharacterized protein LOC103313151 [Tribolium castaneum]>gi|270007744|gb|EFA04192.1| hypothetical protein TcasGA2_TC014441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.66620 BP_3 8.00 3.18 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04689 DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.66621 BP_3 4.00 1.25 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04554 Extensin-like region GO:0009664//GO:0042546 plant-type cell wall organization//cell wall biogenesis GO:0005199 structural constituent of cell wall GO:0005618 cell wall -- -- Cluster-8309.66623 BP_3 6.00 5.11 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66624 BP_3 4.00 0.66 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66627 BP_3 1.00 2.65 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66632 BP_3 3.00 0.37 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66636 BP_3 3.00 0.89 453 805806704 XP_012146119.1 426 1.2e-39 PREDICTED: uncharacterized protein LOC105663206 isoform X2 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66640 BP_3 2.00 0.75 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66647 BP_3 30.90 1.11 1630 356483015 CCE46010.1 391 4.9e-35 putative DEAD-box ATP-dependent RNA helicase [Cancer pagurus] 356483014 HE608876.1 365 0 Cancer pagurus mRNA for putative DEAD-box ATP-dependent RNA helicase (ddx gene) K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 Q4R6M5 285 3.9e-24 Probable ATP-dependent RNA helicase DDX5 OS=Macaca fascicularis GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.66652 BP_3 1.00 0.73 353 -- -- -- -- -- 697069742 XM_009651760.1 347 1.86379e-180 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66654 BP_3 3.00 0.60 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66656 BP_3 17.00 0.55 1774 -- -- -- -- -- 23380399 AY140650.1 218 5.1997e-108 Homarus americanus putative Na+/K+-ATPase alpha subunit mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66666 BP_3 16.00 1.15 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01779 Ribosomal L29e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.66671 BP_3 13.00 2.11 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66681 BP_3 7.85 0.45 1126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66682 BP_3 3.00 0.62 526 -- -- -- -- -- 768311754 CP010982.1 514 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66684 BP_3 67.79 1.12 3220 270003933 EFA00381.1 605 1.5e-59 hypothetical protein TcasGA2_TC003227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66686 BP_3 9.03 0.94 756 642915229 XP_008190531.1 654 7.1e-66 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- K17495 CSMD CUB and sushi domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K17495 Q09101 353 2.4e-32 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.66687 BP_3 2.00 0.51 479 281354432 EFB30016.1 303 2.3e-25 hypothetical protein PANDA_013714, partial [Ailuropoda melanoleuca] -- -- -- -- -- K05612 SLC1A1, EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05612 P51906 298 3.6e-26 Excitatory amino acid transporter 3 OS=Mus musculus GN=Slc1a1 PE=1 SV=2 PF00375 Sodium:dicarboxylate symporter family GO:0006835//GO:0006812//GO:0006820 dicarboxylic acid transport//cation transport//anion transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.66689 BP_3 3.00 1.17 414 780665970 XP_011694053.1 255 7.3e-20 PREDICTED: uncharacterized protein LOC105453629 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66690 BP_3 3.00 1.58 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66691 BP_3 7.55 0.49 1034 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66692 BP_3 25.45 1.43 1152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16499 Alpha galactosidase A GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.66694 BP_3 1.00 0.46 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66698 BP_3 25.00 0.42 3145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66707 BP_3 5.00 0.36 969 662215751 XP_008481774.1 174 4.2e-10 PREDICTED: uncharacterized protein LOC103518485 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66708 BP_3 17.00 1.58 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6671 BP_3 20.00 1.39 983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66710 BP_3 1.00 0.51 384 641648497 XP_008182438.1 219 1.0e-15 PREDICTED: uncharacterized protein LOC100574550 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66712 BP_3 42.00 10.00 494 -- -- -- -- -- 768311753 CP010981.1 304 2.15038e-156 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66713 BP_3 9.00 0.79 839 546676813 ERL87759.1 350 1.4e-30 hypothetical protein D910_05148 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414 TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.66714 BP_3 1.00 0.33 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66715 BP_3 4.00 0.84 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66717 BP_3 5.94 0.37 1070 270001480 EEZ97927.1 477 3.4e-45 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M3K2 159 1.0e-09 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66718 BP_3 20.00 2.34 703 82795517 ABB91672.1 325 9.4e-28 arthrodial cuticle protein AMP13.4 [Callinectes sapidus] 82795516 DQ288147.1 79 3.72319e-31 Callinectes sapidus arthrodial cuticle protein AMP13.4 mRNA, complete cds -- -- -- -- P81578 320 1.5e-28 Cuticle protein AM1239 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.66719 BP_3 10.00 5.27 381 262401197 ACY66501.1 313 1.2e-26 60S acidic ribosomal protein P2 [Scylla paramamosain] 262401196 FJ774780.1 364 0 Scylla paramamosain 60S acidic ribosomal protein P2 mRNA, complete cds K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P42037 165 7.4e-11 60S acidic ribosomal protein P2 OS=Alternaria alternata GN=ALTA5 PE=1 SV=1 PF03088 Strictosidine synthase GO:0009058//GO:0042432//GO:0016114 biosynthetic process//indole biosynthetic process//terpenoid biosynthetic process GO:0016844 strictosidine synthase activity -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-8309.66725 BP_3 5.00 1.24 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66727 BP_3 4.00 1.14 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66731 BP_3 5.00 0.33 1018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66736 BP_3 56.69 1.90 1728 815896315 XP_012246840.1 705 2.0e-71 PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896317|ref|XP_012246847.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896319|ref|XP_012246857.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q9WUW9 404 6.6e-38 Sulfotransferase 1C2A OS=Rattus norvegicus GN=Sult1c2a PE=2 SV=2 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.66737 BP_3 61.00 20.30 436 379054834 AFC88812.1 264 6.9e-21 larvae cuticle protein [Choristoneura fumiferana] -- -- -- -- -- -- -- -- -- P56561 219 4.7e-17 Endocuticle structural glycoprotein ABD-5 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.66745 BP_3 15.00 0.92 1081 546676441 ERL87450.1 693 3.1e-70 hypothetical protein D910_04842, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00462//PF13606//PF06305 Glutaredoxin//Ankyrin repeat//Protein of unknown function (DUF1049) GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.66747 BP_3 5.00 3.14 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66748 BP_3 12.87 0.56 1392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66751 BP_3 6.00 1.07 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66752 BP_3 1.00 1.65 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66753 BP_3 43.00 1.68 1526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66755 BP_3 6.19 0.55 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66756 BP_3 14.81 1.08 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66757 BP_3 2.00 0.95 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66759 BP_3 100.80 2.41 2311 642923044 XP_008200507.1 3157 0.0e+00 PREDICTED: neuroligin-4, X-linked-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N0W4 840 2.4e-88 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF07859//PF14991//PF00898 alpha/beta hydrolase fold//Protein melan-A//Orbivirus outer capsid protein VP2 GO:0008152 metabolic process GO:0005198//GO:0016787 structural molecule activity//hydrolase activity GO:0042470//GO:0019028 melanosome//viral capsid KOG1516 Carboxylesterase and related proteins Cluster-8309.66762 BP_3 6.00 0.52 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66764 BP_3 10.00 0.56 1157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66772 BP_3 1.00 0.34 435 115443587 YP_778606.1 187 5.8e-12 photosystem II protein H [Bigelowiella natans]>gi|122227444|sp|Q06J21.1|PSBH_BIGNA RecName: Full=Photosystem II reaction center protein H; Short=PSII-H; AltName: Full=Photosystem II 10 kDa phosphoprotein (chloroplast) [Bigelowiella natans]>gi|110810232|gb|ABG91438.1| photosystem II protein H [Bigelowiella natans] 761231940 KM881643.1 390 0 Oryza officinalis chloroplast, complete genome -- -- -- -- P0C422 362 1.2e-33 Photosystem II reaction center protein H OS=Oryza sativa subsp. japonica GN=psbH PE=3 SV=1 PF00737 Photosystem II 10 kDa phosphoprotein GO:0050821//GO:0015979 protein stabilization//photosynthesis GO:0042301 phosphate ion binding GO:0009523//GO:0009535//GO:0016020//GO:0016021 photosystem II//chloroplast thylakoid membrane//membrane//integral component of membrane -- -- Cluster-8309.6679 BP_3 5.38 0.39 964 642921092 XP_008192688.1 543 6.8e-53 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q9VDR1 325 5.3e-29 Mediator of RNA polymerase II transcription subunit 25 OS=Drosophila melanogaster GN=MED25 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6683 BP_3 173.00 4.94 1980 91085043 XP_974280.1 1616 5.3e-177 PREDICTED: cytochrome P450 307a1 [Tribolium castaneum]>gi|270009225|gb|EFA05673.1| cytochrome P450 307B1 [Tribolium castaneum] 642926260 XM_969187.2 95 1.38014e-39 PREDICTED: Tribolium castaneum cytochrome P450 307B1 (LOC663127), mRNA K14939 spo, spok, CYP307A cytochrome P450, family 307, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K14939 Q9VRM7 852 8.5e-90 Cytochrome P450 307a1 OS=Drosophila melanogaster GN=spo PE=1 SV=3 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0016705//GO:0009055//GO:0020037//GO:0004497//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity//heme binding//monooxygenase activity//iron ion binding -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.6686 BP_3 29.00 1.29 1373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04397 LytTr DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.669 BP_3 12.00 0.87 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6692 BP_3 2.60 0.33 671 642922159 XP_008193039.1 312 2.9e-26 PREDICTED: nostrin isoform X1 [Tribolium castaneum]>gi|270007234|gb|EFA03682.1| hypothetical protein TcasGA2_TC013784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6694 BP_3 5.53 0.70 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03694 Erg28 like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.670 BP_3 1.00 0.66 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6702 BP_3 14.67 0.42 1993 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6703 BP_3 35.00 0.36 5033 478257339 ENN77499.1 270 1.6e-20 hypothetical protein YQE_06025, partial [Dendroctonus ponderosae]>gi|546679565|gb|ERL90013.1| hypothetical protein D910_07371 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10394 Histone acetyl transferase HAT1 N-terminus GO:0042967//GO:0016568 acyl-carrier-protein biosynthetic process//chromatin modification GO:0004402 histone acetyltransferase activity GO:0000123 histone acetyltransferase complex -- -- Cluster-8309.6705 BP_3 13.00 0.51 1520 641650758 XP_001947263.3 324 2.7e-27 PREDICTED: LOW QUALITY PROTEIN: nucleolin-like [Acyrthosiphon pisum] -- -- -- -- -- K15223 UAF30, SPP27 upstream activation factor subunit UAF30 http://www.genome.jp/dbget-bin/www_bget?ko:K15223 O74503 156 3.3e-09 Upstream activation factor subunit spp27 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=spp27 PE=1 SV=1 PF02724//PF01698//PF04006//PF05470//PF02201 CDC45-like protein//Floricaula / Leafy protein//Mpp10 protein//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//SWIB/MDM2 domain GO:0006446//GO:0006270//GO:0006364//GO:0006413//GO:0006355 regulation of translational initiation//DNA replication initiation//rRNA processing//translational initiation//regulation of transcription, DNA-templated GO:0003677//GO:0003743//GO:0005515//GO:0031369 DNA binding//translation initiation factor activity//protein binding//translation initiation factor binding GO:0034457//GO:0005634//GO:0005840//GO:0005732//GO:0005852 Mpp10 complex//nucleus//ribosome//small nucleolar ribonucleoprotein complex//eukaryotic translation initiation factor 3 complex KOG1946 RNA polymerase I transcription factor UAF Cluster-8309.6706 BP_3 11.00 0.47 1410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6707 BP_3 56.82 0.70 4185 642917603 XP_008191276.1 4611 0.0e+00 PREDICTED: glutamate receptor ionotropic, NMDA 2B isoform X1 [Tribolium castaneum] 666335964 KJ747201.1 399 0 Diploptera punctata NMDA receptor subunit 2 variant A2 (NMDAR 2) mRNA, complete cds, alternatively spliced K05210 GRIN2B glutamate receptor ionotropic, NMDA 2B http://www.genome.jp/dbget-bin/www_bget?ko:K05210 Q5R1P3 1136 2.1e-122 Glutamate receptor ionotropic, NMDA 2B OS=Canis familiaris GN=GRIN2B PE=2 SV=1 PF00193//PF10613//PF05495//PF00060 Extracellular link domain//Ligated ion channel L-glutamate- and glycine-binding site//CHY zinc finger//Ligand-gated ion channel GO:0006811//GO:0007155//GO:0007268//GO:0007165 ion transport//cell adhesion//synaptic transmission//signal transduction GO:0008270//GO:0005234//GO:0004970//GO:0005540 zinc ion binding//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//hyaluronic acid binding GO:0016020 membrane KOG1053 Glutamate-gated NMDA-type ion channel receptor subunit GRIN2A and related subunits Cluster-8309.6710 BP_3 21.00 0.77 1613 237825144 ACR20475.1 530 3.7e-51 mannose-binding protein [Procambarus clarkii] 284520579 GU353177.1 64 1.91388e-22 Eriocheir sinensis mannose-binding protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6711 BP_3 316.29 7.47 2332 642913117 XP_008201398.1 1808 3.4e-199 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.7e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6713 BP_3 283.88 7.27 2173 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6714 BP_3 5.00 0.43 847 554554011 XP_005871471.1 1315 1.8e-142 PREDICTED: 40S ribosomal protein S3a [Myotis brandtii] 694909173 XM_001153182.4 847 0 PREDICTED: Pan troglodytes 40S ribosomal protein S3a {ECO:0000255|HAMAP-Rule:MF_03122} (LOC461536), mRNA K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 P61247 1305 1.1e-142 40S ribosomal protein S3a OS=Homo sapiens GN=RPS3A PE=1 SV=2 PF04083//PF01408//PF01015 Partial alpha/beta-hydrolase lipase region//Oxidoreductase family, NAD-binding Rossmann fold//Ribosomal S3Ae family GO:0042254//GO:0006412//GO:0006629 ribosome biogenesis//translation//lipid metabolic process GO:0003735//GO:0016491 structural constituent of ribosome//oxidoreductase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1628 40S ribosomal protein S3A Cluster-8309.6718 BP_3 9.00 0.65 958 642937193 XP_008198733.1 1330 3.7e-144 PREDICTED: LOW QUALITY PROTEIN: catalase-like [Tribolium castaneum] -- -- -- -- -- K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 O97492 1105 1.9e-119 Catalase OS=Canis familiaris GN=CAT PE=1 SV=3 PF00199 Catalase GO:0006979//GO:0006804//GO:0055114//GO:0006568//GO:0015947 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process//tryptophan metabolic process//methane metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-8309.6719 BP_3 1.00 0.55 376 642937193 XP_008198733.1 356 1.3e-31 PREDICTED: LOW QUALITY PROTEIN: catalase-like [Tribolium castaneum] -- -- -- -- -- K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 298 2.8e-26 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 PF00199 Catalase GO:0006568//GO:0015947//GO:0006979//GO:0006804//GO:0055114 tryptophan metabolic process//methane metabolic process//response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004096//GO:0020037 catalase activity//heme binding -- -- KOG0047 Catalase Cluster-8309.6720 BP_3 4.00 0.67 578 642937193 XP_008198733.1 312 2.5e-26 PREDICTED: LOW QUALITY PROTEIN: catalase-like [Tribolium castaneum] -- -- -- -- -- K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 258 1.9e-21 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0047 Catalase Cluster-8309.6726 BP_3 36.00 4.67 663 766937328 XP_011501111.1 860 8.2e-90 PREDICTED: 40S ribosomal protein S8 [Ceratosolen solmsi marchali] 70909498 AM048936.1 122 4.37091e-55 Carabus granulatus partial mRNA for ribosomal protein S8e (rpS8e gene) K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 O76756 848 8.3e-90 40S ribosomal protein S8 OS=Apis mellifera GN=RpS8 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3283 40S ribosomal protein S8 Cluster-8309.6727 BP_3 5.00 0.50 777 380012480 XP_003690309.1 136 8.5e-06 PREDICTED: uncharacterized protein LOC100863388 [Apis florea] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05408 Foot-and-mouth virus L-proteinase GO:0019082//GO:0006508//GO:0016032 viral protein processing//proteolysis//viral process GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.6728 BP_3 28.00 0.34 4257 148229051 NP_001081037.1 730 6.2e-74 serine/threonine-protein kinase pim-3 [Xenopus laevis]>gi|3914355|sp|Q91822.1|PIM3_XENLA RecName: Full=Serine/threonine-protein kinase pim-3; AltName: Full=Pim-1 [Xenopus laevis]>gi|1161306|gb|AAA85389.1| autophosphorylation sites at tyrosine 239 and serine 262 [Xenopus laevis] -- -- -- -- -- K04702 PIM1 proto-oncogene serine/threonine-protein kinase Pim-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04702 Q91822 730 2.6e-75 Serine/threonine-protein kinase pim-3 OS=Xenopus laevis GN=pim3 PE=1 SV=1 PF07714//PF03153//PF00069//PF06293 Protein tyrosine kinase//Transcription factor IIA, alpha/beta subunit//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0016310//GO:0006468//GO:0006367 phosphorylation//protein phosphorylation//transcription initiation from RNA polymerase II promoter GO:0005524//GO:0004672//GO:0000166//GO:0016773 ATP binding//protein kinase activity//nucleotide binding//phosphotransferase activity, alcohol group as acceptor GO:0016020//GO:0005672 membrane//transcription factor TFIIA complex KOG0611 Predicted serine/threonine protein kinase Cluster-8309.6734 BP_3 4.00 0.49 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04142//PF07829 Nucleotide-sugar transporter//Alpha-A conotoxin PIVA-like protein GO:0008643//GO:0007268//GO:0009405//GO:0007165 carbohydrate transport//synaptic transmission//pathogenesis//signal transduction GO:0030550//GO:0005351 acetylcholine receptor inhibitor activity//sugar:proton symporter activity GO:0000139//GO:0005576//GO:0016021 Golgi membrane//extracellular region//integral component of membrane -- -- Cluster-8309.6736 BP_3 3.00 0.49 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.674 BP_3 2.00 0.54 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6743 BP_3 9.00 0.80 832 752898427 XP_011267568.1 867 1.6e-90 PREDICTED: general transcription factor II-I repeat domain-containing protein 2B-like [Camponotus floridanus] 805826718 XM_012297832.1 493 0 PREDICTED: Megachile rotundata general transcription factor II-I repeat domain-containing protein 2B-like (LOC105664219), partial mRNA -- -- -- -- Q6R2W3 124 9.3e-06 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6744 BP_3 6.09 0.51 870 861614479 KMQ85882.1 313 2.9e-26 transposon ty3-g gag-pol polyprotein isoform x2 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07464//PF00665//PF13683 Apolipophorin-III precursor (apoLp-III)//Integrase core domain//Integrase core domain GO:0015074//GO:0006869 DNA integration//lipid transport GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.6745 BP_3 203.00 6.82 1726 568983990 XP_006517560.1 307 2.8e-25 PREDICTED: zinc finger protein 431-like isoform X2 [Mus musculus] -- -- -- -- -- -- -- -- -- Q8NDP4 297 1.7e-25 Zinc finger protein 439 OS=Homo sapiens GN=ZNF439 PE=1 SV=1 PF13465//PF00096//PF13912//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.6747 BP_3 5.02 0.65 666 642928992 XP_008195647.1 307 1.1e-25 PREDICTED: endoplasmic reticulum metallopeptidase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VGW4 141 7.9e-08 Endoplasmic reticulum metallopeptidase 1 OS=Xenopus laevis GN=ermp1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6750 BP_3 3.22 1.43 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6752 BP_3 8.00 0.70 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6756 BP_3 8.38 1.96 498 332373050 AEE61666.1 477 1.6e-45 unknown [Dendroctonus ponderosae]>gi|478255707|gb|ENN75918.1| hypothetical protein YQE_07559, partial [Dendroctonus ponderosae] -- -- -- -- -- K15284 SLC35E2 solute carrier family 35, member E2 http://www.genome.jp/dbget-bin/www_bget?ko:K15284 Q8C811 357 5.3e-33 Solute carrier family 35 member E2 OS=Mus musculus GN=Slc35e2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.6758 BP_3 4.00 0.64 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6769 BP_3 18.00 2.34 663 91076462 XP_971946.1 587 3.7e-58 PREDICTED: protein trunk [Tribolium castaneum]>gi|270002904|gb|EEZ99351.1| trunk [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24155 377 3.4e-35 Protein trunk OS=Drosophila melanogaster GN=trk PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6775 BP_3 96.06 1.78 2886 270007789 EFA04237.1 799 4.2e-82 hypothetical protein TcasGA2_TC014490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4G0P3 604 7.1e-61 Hydrocephalus-inducing protein homolog OS=Homo sapiens GN=HYDIN PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6777 BP_3 8.62 0.89 759 646699579 KDR10133.1 329 3.5e-28 cAMP-responsive element-binding protein-like 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O60519 269 1.3e-22 cAMP-responsive element-binding protein-like 2 OS=Homo sapiens GN=CREBL2 PE=1 SV=1 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.678 BP_3 6.00 0.55 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07352 Bacteriophage Mu Gam like protein GO:0042262 DNA protection GO:0003690 double-stranded DNA binding -- -- -- -- Cluster-8309.6784 BP_3 4.00 0.59 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6785 BP_3 26.85 2.20 880 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.679 BP_3 14.16 0.86 1085 642936139 XP_008198314.1 220 2.2e-15 PREDICTED: T-cell leukemia homeobox protein 2 [Tribolium castaneum]>gi|270014244|gb|EFA10692.1| hypothetical protein TcasGA2_TC011749 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.6794 BP_3 9.93 0.33 1722 642920067 XP_008192192.1 442 6.3e-41 PREDICTED: nuclear RNA export factor 2-like [Tribolium castaneum]>gi|270005996|gb|EFA02444.1| hypothetical protein TcasGA2_TC008131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99257 150 1.9e-08 mRNA export factor MEX67 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MEX67 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6795 BP_3 10.00 0.37 1610 297251407 ADI24987.1 1941 8.9e-215 chitin deacetylase 1 precursor [Cherax quadricarinatus] 121484227 EF102018.1 591 0 Portunus pelagicus vermiform cuticle protein VER1 mRNA, complete cds -- -- -- -- -- -- -- -- PF00642//PF02879//PF01607 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Chitin binding Peritrophin-A domain GO:0006030//GO:0005975 chitin metabolic process//carbohydrate metabolic process GO:0046872//GO:0008061 metal ion binding//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.6797 BP_3 2.68 0.39 621 478251157 ENN71633.1 308 7.8e-26 hypothetical protein YQE_11731, partial [Dendroctonus ponderosae]>gi|546685819|gb|ERL95262.1| hypothetical protein D910_12528 [Dendroctonus ponderosae] -- -- -- -- -- K02087 CDK1, CDC2 cyclin-dependent kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02087 P51958 277 1.3e-23 Cyclin-dependent kinase 1 OS=Carassius auratus GN=cdk1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.6798 BP_3 12.00 0.88 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF15550//PF15748 Presenilin//Draxin//Centriole, cilia and spindle-associated GO:0016055//GO:0007411 Wnt signaling pathway//axon guidance GO:0004190 aspartic-type endopeptidase activity GO:0005856//GO:0016021//GO:0005576 cytoskeleton//integral component of membrane//extracellular region -- -- Cluster-8309.681 BP_3 29.05 1.54 1200 646713613 KDR17904.1 1314 3.4e-142 Actin, clone 403 [Zootermopsis nevadensis] 558184753 XM_006128029.1 268 5.58673e-136 PREDICTED: Pelodiscus sinensis actin, cytoplasmic type 5-like (LOC102458214), mRNA K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P49871 1299 7.6e-142 Actin, muscle OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.6811 BP_3 26.00 5.54 518 328899546 AEB54640.1 455 5.8e-43 ribosomal protein L24 [Procambarus clarkii] -- -- -- -- -- K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q962T5 372 1.0e-34 60S ribosomal protein L24 OS=Spodoptera frugiperda GN=RpL24 PE=2 SV=1 PF02932//PF07565//PF01080//PF03222 Neurotransmitter-gated ion-channel transmembrane region//Band 3 cytoplasmic domain//Presenilin//Tryptophan/tyrosine permease family GO:0003333//GO:0006820//GO:0006811 amino acid transmembrane transport//anion transport//ion transport GO:0008509//GO:0004190 anion transmembrane transporter activity//aspartic-type endopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1722 60s ribosomal protein L24 Cluster-8309.6812 BP_3 9.94 0.53 1201 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.6818 BP_3 6.00 1.00 580 807039402 XP_012160763.1 348 1.7e-30 PREDICTED: muscle LIM protein Mlp84B isoform X1 [Ceratitis capitata] -- -- -- -- -- K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 331 6.4e-30 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.6819 BP_3 100.46 2.90 1962 642924462 XP_008194308.1 1489 2.8e-162 PREDICTED: G2/mitotic-specific cyclin-B3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05868 CCNB cyclin B http://www.genome.jp/dbget-bin/www_bget?ko:K05868 Q9I7I0 936 1.5e-99 G2/mitotic-specific cyclin-B3 OS=Drosophila melanogaster GN=CycB3 PE=1 SV=1 PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus KOG0653 Cyclin B and related kinase-activating proteins Cluster-8309.6825 BP_3 2.00 0.40 535 270008852 EFA05300.1 154 4.8e-08 hypothetical protein TcasGA2_TC015457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6826 BP_3 116.00 1.32 4522 270006719 EFA03167.1 910 8.9e-95 hypothetical protein TcasGA2_TC013087 [Tribolium castaneum] -- -- -- -- -- K10878 SPO11 meiotic recombination protein SPO11 http://www.genome.jp/dbget-bin/www_bget?ko:K10878 Q9Y5K1 578 1.1e-57 Meiotic recombination protein SPO11 OS=Homo sapiens GN=SPO11 PE=2 SV=1 PF05199//PF04406 GMC oxidoreductase//Type IIB DNA topoisomerase GO:0006259//GO:0055114 DNA metabolic process//oxidation-reduction process GO:0003677//GO:0016614//GO:0003824//GO:0005524 DNA binding//oxidoreductase activity, acting on CH-OH group of donors//catalytic activity//ATP binding GO:0005694 chromosome KOG2795 Catalytic subunit of the meiotic double strand break transesterase Cluster-8309.6827 BP_3 28.00 3.25 707 6831612 Q9XYC2.3 865 2.3e-90 RecName: Full=60S ribosomal protein L15 [Orconectes limosus]>gi|4530186|gb|AAD21924.1| L15-like ribosomal protein [Orconectes limosus] 31322597 AY249411.1 144 2.75552e-67 Anguilla japonica ribosomal protein L15 (rpl15) mRNA, complete cds K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 Q9XYC2 865 9.4e-92 60S ribosomal protein L15 OS=Orconectes limosus GN=RPL15 PE=2 SV=3 PF00827 Ribosomal L15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-8309.6829 BP_3 77.36 1.70 2491 642920067 XP_008192192.1 640 9.9e-64 PREDICTED: nuclear RNA export factor 2-like [Tribolium castaneum]>gi|270005996|gb|EFA02444.1| hypothetical protein TcasGA2_TC008131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GZY0 309 9.8e-27 Nuclear RNA export factor 2 OS=Homo sapiens GN=NXF2 PE=1 SV=1 PF03943//PF13855//PF02136 TAP C-terminal domain//Leucine rich repeat//Nuclear transport factor 2 (NTF2) domain GO:0006810//GO:0051028 transport//mRNA transport GO:0005515 protein binding GO:0005622//GO:0005634 intracellular//nucleus KOG3763 mRNA export factor TAP/MEX67 Cluster-8309.683 BP_3 480.76 19.80 1462 478259313 ENN79215.1 809 1.5e-83 hypothetical protein YQE_04399, partial [Dendroctonus ponderosae]>gi|546675051|gb|ERL86306.1| hypothetical protein D910_03714 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6833 BP_3 10.00 1.90 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6838 BP_3 2.00 0.89 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6841 BP_3 39.00 0.45 4486 91089283 XP_970929.1 295 1.8e-23 PREDICTED: protein phosphatase PTC7 homolog [Tribolium castaneum]>gi|270012497|gb|EFA08945.1| hypothetical protein TcasGA2_TC006652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U3N5 213 2.4e-15 Protein phosphatase PTC7 homolog OS=Danio rerio GN=pptc7 PE=2 SV=1 -- -- GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1379 Serine/threonine protein phosphatase Cluster-8309.6843 BP_3 1332.00 72.03 1183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6853 BP_3 4.00 1.48 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6862 BP_3 5.00 0.36 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6865 BP_3 38.02 5.48 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6867 BP_3 4.00 0.39 792 642935715 XP_008198140.1 203 1.5e-13 PREDICTED: beclin 1-associated autophagy-related key regulator [Tribolium castaneum] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 Q6ZNE5 145 3.3e-08 Beclin 1-associated autophagy-related key regulator OS=Homo sapiens GN=ATG14 PE=1 SV=1 PF10186 Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy -- -- -- -- -- -- Cluster-8309.687 BP_3 19.90 1.07 1192 270015285 EFA11733.1 244 3.9e-18 hypothetical protein TcasGA2_TC002382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01352//PF17051 KRAB box//Cytochrome C oxidase assembly factor 2 GO:0033617//GO:0006355 mitochondrial respiratory chain complex IV assembly//regulation of transcription, DNA-templated GO:0003676 nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.6878 BP_3 18.65 0.85 1343 546682185 ERL92154.1 286 6.0e-23 hypothetical protein D910_09474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.688 BP_3 4.00 0.39 780 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6886 BP_3 156.13 0.93 8423 332372792 AEE61538.1 1085 8.4e-115 unknown [Dendroctonus ponderosae] 805783396 XM_012284418.1 162 3.38212e-76 PREDICTED: Megachile rotundata tRNA (guanine-N(7)-)-methyltransferase (LOC100882994), transcript variant X3, mRNA K03439 trmB, METTL1 tRNA (guanine-N7-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03439 Q1HPU2 957 2.4e-101 tRNA (guanine-N(7)-)-methyltransferase OS=Bombyx mori PE=2 SV=1 PF13855//PF05175//PF00560//PF02390 Leucine rich repeat//Methyltransferase small domain//Leucine Rich Repeat//Putative methyltransferase GO:0009451//GO:0008033//GO:0006400 RNA modification//tRNA processing//tRNA modification GO:0008176//GO:0008168//GO:0005515 tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//protein binding -- -- KOG3115 Methyltransferase-like protein Cluster-8309.6887 BP_3 43.57 1.46 1731 91094771 XP_967866.1 1575 2.6e-172 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1005 1.3e-107 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.6888 BP_3 45.49 0.38 5992 270005719 EFA02167.1 2698 5.5e-302 hypothetical protein TcasGA2_TC007822 [Tribolium castaneum] 752895957 XM_011267918.1 291 4.67757e-148 PREDICTED: Camponotus floridanus potassium voltage-gated channel subfamily KQT member 1 (LOC105257354), transcript variant X6, mRNA K04926 KCNQ1 potassium voltage-gated channel KQT-like subfamily member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04926 O73925 1571 1.1e-172 Potassium voltage-gated channel subfamily KQT member 1 OS=Squalus acanthias GN=KCNQ1 PE=2 SV=1 PF00612//PF04505//PF00520 IQ calmodulin-binding motif//Interferon-induced transmembrane protein//Ion transport protein GO:0006811//GO:0055085//GO:0009607 ion transport//transmembrane transport//response to biotic stimulus GO:0005515//GO:0005216 protein binding//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1419 Voltage-gated K+ channel KCNQ Cluster-8309.689 BP_3 167.00 3.31 2727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08476//PF04099 Viral D10 N-terminal//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport GO:0016791 phosphatase activity GO:0005801 cis-Golgi network -- -- Cluster-8309.6890 BP_3 35.00 0.38 4730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6892 BP_3 3.00 0.32 742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.690 BP_3 1.00 0.34 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6900 BP_3 4.00 0.49 685 861584709 KMQ82364.1 380 3.8e-34 reverse transcriptase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- P21328 249 2.4e-20 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila melanogaster GN=pol PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6901 BP_3 53.31 0.76 3654 642928611 XP_008199978.1 2266 4.1e-252 PREDICTED: FERM domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UFK8 523 2.2e-51 FERM domain-containing protein 8 OS=Mus musculus GN=Frmd8 PE=1 SV=2 PF01527//PF04218 Transposase//CENP-B N-terminal DNA-binding domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- KOG4335 FERM domain-containing protein KRIT1 Cluster-8309.6905 BP_3 7.24 0.31 1428 270003416 EEZ99863.1 145 1.4e-06 hypothetical protein TcasGA2_TC002645 [Tribolium castaneum] 462368172 APGK01026643.1 34 8.02909e-06 Dendroctonus ponderosae Seq01026653, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6906 BP_3 37.78 0.45 4350 642917423 XP_008191192.1 1857 1.3e-204 PREDICTED: serologically defined colon cancer antigen 8 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B8JK76 289 3.6e-24 Serologically defined colon cancer antigen 8 homolog OS=Danio rerio GN=Sdccag8 PE=3 SV=2 PF01544//PF04824//PF08702//PF02183//PF02050//PF05837//PF15964//PF00201 CorA-like Mg2+ transporter protein//Conserved region of Rad21 / Rec8 like protein//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Flagellar FliJ protein//Centromere protein H (CENP-H)//Centrosomal colon cancer autoantigen protein family//UDP-glucoronosyl and UDP-glucosyl transferase GO:0051258//GO:0055085//GO:0007165//GO:0051382//GO:0006355//GO:0071973//GO:0051297//GO:0006935//GO:0030001//GO:0008152//GO:0030168 protein polymerization//transmembrane transport//signal transduction//kinetochore assembly//regulation of transcription, DNA-templated//bacterial-type flagellum-dependent cell motility//centrosome organization//chemotaxis//metal ion transport//metabolic process//platelet activation GO:0016758//GO:0003700//GO:0005102//GO:0043565//GO:0003774//GO:0046873//GO:0030674 transferase activity, transferring hexosyl groups//transcription factor activity, sequence-specific DNA binding//receptor binding//sequence-specific DNA binding//motor activity//metal ion transmembrane transporter activity//protein binding, bridging GO:0005577//GO:0000228//GO:0009288//GO:0005667//GO:0005813//GO:0000776//GO:0016020 fibrinogen complex//nuclear chromosome//bacterial-type flagellum//transcription factor complex//centrosome//kinetochore//membrane -- -- Cluster-8309.6909 BP_3 127.17 7.26 1136 817212892 XP_012282645.1 439 9.2e-41 PREDICTED: pyridoxine-5'-phosphate oxidase-like isoform X2 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q487G8 254 1.1e-20 Pyridoxine/pyridoxamine 5'-phosphate oxidase OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=pdxH PE=3 SV=1 PF01243//PF12766//PF04420//PF10590 Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//CHD5-like protein//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region GO:0055114//GO:0008615//GO:0071816 oxidation-reduction process//pyridoxine biosynthetic process//tail-anchored membrane protein insertion into ER membrane GO:0004733//GO:0016638//GO:0010181 pyridoxamine-phosphate oxidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//FMN binding -- -- KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.691 BP_3 182.36 14.84 884 642911045 XP_008200617.1 477 2.8e-45 PREDICTED: uncharacterized protein LOC100142534 [Tribolium castaneum]>gi|642911047|ref|XP_001806882.2| PREDICTED: uncharacterized protein LOC100142534 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6916 BP_3 12.72 2.03 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6920 BP_3 5.00 0.39 905 646706235 KDR13572.1 738 1.6e-75 hypothetical protein L798_12353 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6922 BP_3 108.00 2.92 2073 91094101 XP_967213.1 1872 1.1e-206 PREDICTED: tubulin--tyrosine ligase-like protein 12 [Tribolium castaneum]>gi|270010885|gb|EFA07333.1| hypothetical protein TcasGA2_TC015929 [Tribolium castaneum] -- -- -- -- -- K16609 TTLL12 tubulin--tyrosine ligase-like protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K16609 Q14166 1204 1.4e-130 Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens GN=TTLL12 PE=1 SV=2 PF03133//PF04120 Tubulin-tyrosine ligase family//Low affinity iron permease GO:0055085//GO:0006464 transmembrane transport//cellular protein modification process -- -- -- -- KOG2155 Tubulin-tyrosine ligase-related protein Cluster-8309.6929 BP_3 112.74 3.40 1888 91088681 XP_974930.1 756 2.7e-77 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99536 372 3.7e-34 Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens GN=VAT1 PE=1 SV=2 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0005488 binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.693 BP_3 5943.21 494.52 871 91091646 XP_970895.1 344 7.3e-30 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000889|gb|EEZ97336.1| hypothetical protein TcasGA2_TC011148 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45583 215 2.7e-16 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00366//PF00379 Ribosomal protein S17//Insect cuticle protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0042302 structural constituent of ribosome//structural constituent of cuticle GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.6932 BP_3 1.00 0.52 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6936 BP_3 54.32 1.09 2703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6939 BP_3 3.00 0.42 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.694 BP_3 62.64 3.98 1050 642911045 XP_008200617.1 477 3.3e-45 PREDICTED: uncharacterized protein LOC100142534 [Tribolium castaneum]>gi|642911047|ref|XP_001806882.2| PREDICTED: uncharacterized protein LOC100142534 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6947 BP_3 21.62 0.32 3561 642916919 XP_008199554.1 1572 1.2e-171 PREDICTED: F-box/LRR-repeat protein 16 [Tribolium castaneum] 642916918 XM_008201332.1 373 0 PREDICTED: Tribolium castaneum F-box/LRR-repeat protein 16 (LOC660141), mRNA K10282 FBXL16 F-box and leucine-rich repeat protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K10282 A2RT62 1122 7.5e-121 F-box/LRR-repeat protein 16 OS=Mus musculus GN=Fbxl16 PE=2 SV=1 PF00560//PF03876//PF13855//PF13516 Leucine Rich Repeat//SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Leucine rich repeat//Leucine Rich repeat GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0005515//GO:0003899 protein binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3297 DNA-directed RNA polymerase subunit E' Cluster-8309.6950 BP_3 55.00 2.91 1203 270013588 EFA10036.1 148 5.4e-07 hypothetical protein TcasGA2_TC012208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6952 BP_3 9.00 0.39 1396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6954 BP_3 4.00 0.33 875 478258143 ENN78281.1 160 1.6e-08 hypothetical protein YQE_05432, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.6966 BP_3 21.00 0.45 2550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6967 BP_3 169.74 17.32 764 546681081 ERL91237.1 468 2.7e-44 hypothetical protein D910_08573 [Dendroctonus ponderosae] -- -- -- -- -- K17430 MRPL49, NOF1 large subunit ribosomal protein L49 http://www.genome.jp/dbget-bin/www_bget?ko:K17430 Q9VYI3 311 1.8e-27 Probable 39S ribosomal protein L49, mitochondrial OS=Drosophila melanogaster GN=mRpL49 PE=3 SV=1 PF05046 Mitochondrial large subunit ribosomal protein (Img2) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG4034 Uncharacterized conserved protein NOF (Neighbor of FAU) Cluster-8309.6968 BP_3 4.26 0.39 819 546681081 ERL91237.1 462 1.4e-43 hypothetical protein D910_08573 [Dendroctonus ponderosae] -- -- -- -- -- K17430 MRPL49, NOF1 large subunit ribosomal protein L49 http://www.genome.jp/dbget-bin/www_bget?ko:K17430 Q9VYI3 311 1.9e-27 Probable 39S ribosomal protein L49, mitochondrial OS=Drosophila melanogaster GN=mRpL49 PE=3 SV=1 PF05046 Mitochondrial large subunit ribosomal protein (Img2) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG4034 Uncharacterized conserved protein NOF (Neighbor of FAU) Cluster-8309.6969 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6977 BP_3 39.10 0.78 2708 642927615 XP_008195335.1 1899 1.1e-209 PREDICTED: ribosomal protein S6 kinase delta-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R2S1 381 4.8e-35 Ribosomal protein S6 kinase-like 1 OS=Mus musculus GN=Rps6kl1 PE=1 SV=1 PF13414//PF00787//PF00069//PF13374//PF07714//PF13181//PF00515 TPR repeat//PX domain//Protein kinase domain//Tetratricopeptide repeat//Protein tyrosine kinase//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006468 protein phosphorylation GO:0035091//GO:0005515//GO:0004672//GO:0005524 phosphatidylinositol binding//protein binding//protein kinase activity//ATP binding -- -- -- -- Cluster-8309.698 BP_3 10.55 0.67 1046 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6982 BP_3 51.00 10.67 522 642925599 XP_008194616.1 312 2.3e-26 PREDICTED: hornerin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.6983 BP_3 239.00 7.46 1836 642925599 XP_008194616.1 729 3.5e-74 PREDICTED: hornerin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.699 BP_3 38.31 0.76 2720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6995 BP_3 6.00 0.57 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6998 BP_3 35.13 0.64 2923 91085863 XP_966472.1 1237 6.9e-133 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.700 BP_3 17.00 1.10 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7001 BP_3 3.00 1.50 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7004 BP_3 6.00 0.70 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7005 BP_3 23.00 0.96 1452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7007 BP_3 195.53 5.09 2142 642920396 XP_008192329.1 319 1.4e-26 PREDICTED: uncharacterized protein LOC103312721 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.701 BP_3 4660.00 652.36 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7017 BP_3 13.00 0.52 1507 817203758 XP_012277721.1 297 3.6e-24 PREDICTED: uncharacterized protein LOC105698239 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03223//PF02944 V-ATPase subunit C//BESS motif GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0003677 hydrogen ion transmembrane transporter activity//DNA binding GO:0033180 proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.7023 BP_3 41.00 0.45 4646 665788269 XP_008559724.1 685 1.1e-68 PREDICTED: uncharacterized protein LOC103579935 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P34457 142 4.2e-07 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665//PF02211 Integrase core domain//Nitrile hydratase beta subunit GO:0042207//GO:0015074//GO:0018874//GO:0006568 styrene catabolic process//DNA integration//benzoate metabolic process//tryptophan metabolic process GO:0018822 nitrile hydratase activity -- -- -- -- Cluster-8309.7028 BP_3 84.04 2.44 1953 642922564 XP_008193228.1 600 3.4e-59 PREDICTED: inhibitor of growth protein 5 isoform X2 [Tribolium castaneum] 170041067 XM_001848247.1 126 7.96243e-57 Culex quinquefasciatus inhibitor of growth protein, ing4, mRNA K11346 ING4 inhibitor of growth protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11346 Q5ZKY4 378 7.7e-35 Inhibitor of growth protein 4 OS=Gallus gallus GN=ING4 PE=2 SV=1 PF06320//PF00103//PF00628 GCN5-like protein 1 (GCN5L1)//Somatotropin hormone family//PHD-finger GO:0007165 signal transduction GO:0005515//GO:0005179 protein binding//hormone activity GO:0031083//GO:0005576 BLOC-1 complex//extracellular region KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.7030 BP_3 53.00 6.35 694 328899526 AEB54639.1 757 7.5e-78 ribosomal protein L13 [Procambarus clarkii] 338224469 HM217883.1 165 5.7266e-79 Scylla paramamosain ribosomal protein rpl13 mRNA, partial cds K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 Q90YV5 526 1.9e-52 60S ribosomal protein L13 OS=Ictalurus punctatus GN=rpl13 PE=2 SV=3 PF01294 Ribosomal protein L13e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3295 60S Ribosomal protein L13 Cluster-8309.7035 BP_3 10.00 6.14 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7038 BP_3 4.00 0.45 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.704 BP_3 6.00 0.34 1138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7042 BP_3 11.70 0.57 1281 642932264 XP_008197038.1 646 1.0e-64 PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum]>gi|642932266|ref|XP_008197039.1| PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K13349 MPV17L Mpv17-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K13349 Q68F62 299 7.3e-26 Mpv17-like protein OS=Xenopus laevis GN=mpv17l PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.7043 BP_3 14.96 0.38 2183 642932272 XP_008197042.1 431 1.5e-39 PREDICTED: mpv17-like protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K13349 MPV17L Mpv17-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K13349 Q68F62 238 1.5e-18 Mpv17-like protein OS=Xenopus laevis GN=mpv17l PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.7044 BP_3 65.07 4.21 1037 642932264 XP_008197038.1 646 8.3e-65 PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum]>gi|642932266|ref|XP_008197039.1| PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K13349 MPV17L Mpv17-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K13349 Q68F62 299 5.9e-26 Mpv17-like protein OS=Xenopus laevis GN=mpv17l PE=2 SV=1 PF06736//PF04117 Protein of unknown function (DUF1211)//Mpv17 / PMP22 family GO:0006813 potassium ion transport GO:0005267 potassium channel activity GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.7051 BP_3 7.00 0.80 711 642916527 XP_008191079.1 451 2.3e-42 PREDICTED: glutamate receptor ionotropic, kainate 2-like [Tribolium castaneum] -- -- -- -- -- K05205 GRIK5 glutamate receptor, ionotropic kainate 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05205 Q61626 167 8.2e-11 Glutamate receptor ionotropic, kainate 5 OS=Mus musculus GN=Grik5 PE=2 SV=2 PF01155 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0016151 nickel cation binding -- -- -- -- Cluster-8309.7056 BP_3 22.00 0.49 2460 817222402 XP_012286576.1 304 9.0e-25 PREDICTED: tyrosine-protein kinase Dnt-like isoform X3 [Orussus abietinus] -- -- -- -- -- K05128 RYK RYK receptor-like tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05128 Q9V422 265 1.2e-21 Tyrosine-protein kinase Dnt OS=Drosophila melanogaster GN=dnt PE=2 SV=2 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.7066 BP_3 4.00 0.52 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7071 BP_3 161.05 32.56 530 478259443 ENN79333.1 141 1.5e-06 hypothetical protein YQE_04242, partial [Dendroctonus ponderosae]>gi|546675184|gb|ERL86420.1| hypothetical protein D910_03827 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7076 BP_3 3.00 0.59 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7079 BP_3 1.00 0.46 396 642931615 XP_008196657.1 179 4.5e-11 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Tribolium castaneum] 807033681 XM_004529871.2 53 5.73922e-17 PREDICTED: Ceratitis capitata DNA-directed RNA polymerases I, II, and III subunit RPABC4 (LOC101457024), mRNA K03009 RPB12, POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 http://www.genome.jp/dbget-bin/www_bget?ko:K03009 Q3ZBC0 162 1.7e-10 DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Bos taurus GN=POLR2K PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3507 DNA-directed RNA polymerase, subunit RPB7.0 Cluster-8309.708 BP_3 10.00 1.08 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7090 BP_3 50.71 1.72 1710 642923261 XP_008193681.1 877 2.2e-91 PREDICTED: T-cell activation inhibitor, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 316 1.0e-27 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7093 BP_3 27.08 0.58 2524 815809592 XP_012225671.1 1082 5.6e-115 PREDICTED: irregular chiasm C-roughest protein isoform X2 [Linepithema humile] 642940417 XM_008193059.1 212 1.61096e-104 PREDICTED: Tribolium castaneum poliovirus receptor-related protein 3-like (LOC103312443), partial mRNA -- -- -- -- Q9JLB9 175 3.4e-11 Nectin-3 OS=Mus musculus GN=Pvrl3 PE=1 SV=1 PF08086//PF13895 Ergtoxin family//Immunoglobulin domain GO:0009405//GO:0006810 pathogenesis//transport GO:0005515//GO:0019870 protein binding//potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.7095 BP_3 37.00 1.39 1575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05996 Ferredoxin-dependent bilin reductase GO:0010024//GO:0055114 phytochromobilin biosynthetic process//oxidation-reduction process GO:0050897//GO:0016636 cobalt ion binding//oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor -- -- -- -- Cluster-8309.710 BP_3 2.00 0.38 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7106 BP_3 15.20 1.05 987 270017009 EFA13455.1 299 1.4e-24 hypothetical protein TcasGA2_TC010686 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7107 BP_3 11.97 0.53 1378 270017009 EFA13455.1 299 1.9e-24 hypothetical protein TcasGA2_TC010686 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7108 BP_3 22.82 1.90 871 642932139 XP_008196871.1 220 1.7e-15 PREDICTED: tachykinins [Tribolium castaneum]>gi|270012728|gb|EFA09176.1| tachykinin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.711 BP_3 23.60 0.46 2758 259906455 NP_001159383.1 916 1.1e-95 cacophony A [Tribolium castaneum]>gi|258674483|gb|ACV86998.1| cacophony A [Tribolium castaneum] 259906454 NM_001165911.1 211 6.33445e-104 Tribolium castaneum cacophony A (Cac), mRNA >gnl|BL_ORD_ID|7385018 Tribolium castaneum cacophony A (CAC) mRNA, complete cds K04852 CACNA1E voltage-dependent calcium channel R type alpha-1E http://www.genome.jp/dbget-bin/www_bget?ko:K04852 P91645 843 1.3e-88 Voltage-dependent calcium channel type A subunit alpha-1 OS=Drosophila melanogaster GN=cac PE=2 SV=3 PF00520//PF13405//PF00036 Ion transport protein//EF-hand domain//EF hand GO:0034765//GO:0006811//GO:0070588//GO:0006816//GO:0055085 regulation of ion transmembrane transport//ion transport//calcium ion transmembrane transport//calcium ion transport//transmembrane transport GO:0005245//GO:0005216//GO:0005509 voltage-gated calcium channel activity//ion channel activity//calcium ion binding GO:0005891//GO:0016020 voltage-gated calcium channel complex//membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.7112 BP_3 7.20 0.59 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04487 CITED GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.7116 BP_3 68.00 0.93 3832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7120 BP_3 45.00 2.19 1282 270006433 EFA02881.1 945 2.2e-99 sloppy-paired 2 [Tribolium castaneum] 584010153 XM_006799949.1 116 1.87514e-51 PREDICTED: Neolamprologus brichardi forkhead box protein G1-like (LOC102798061), mRNA K09385 FOXG forkhead box protein G http://www.genome.jp/dbget-bin/www_bget?ko:K09385 P32031 555 1.5e-55 Fork head domain transcription factor slp2 OS=Drosophila melanogaster GN=slp2 PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.7132 BP_3 1.00 0.79 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7133 BP_3 7.00 0.32 1341 478251118 ENN71594.1 1496 2.9e-163 hypothetical protein YQE_11693, partial [Dendroctonus ponderosae]>gi|546680340|gb|ERL90626.1| hypothetical protein D910_07973 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BQT2 326 5.6e-29 Protein FAM69C OS=Mus musculus GN=Fam69c PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7134 BP_3 8.21 0.61 936 546674959 ERL86229.1 473 8.6e-45 hypothetical protein D910_03640 [Dendroctonus ponderosae] 805782450 XM_012284176.1 89 1.38588e-36 PREDICTED: Megachile rotundata protein daughterless (LOC100877694), transcript variant X15, mRNA K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P11420 376 6.3e-35 Protein daughterless OS=Drosophila melanogaster GN=da PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3910 Helix loop helix transcription factor Cluster-8309.7138 BP_3 1.00 13.75 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.714 BP_3 9.32 0.49 1216 91091646 XP_970895.1 209 4.6e-14 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000889|gb|EEZ97336.1| hypothetical protein TcasGA2_TC011148 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 159 1.2e-09 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.7148 BP_3 10.00 0.36 1639 498971523 XP_004527084.1 998 2.0e-105 PREDICTED: jerky protein homolog-like [Ceratitis capitata]>gi|499002503|ref|XP_004534854.1| PREDICTED: jerky protein homolog-like [Ceratitis capitata] -- -- -- -- -- -- -- -- -- Q9Y4A0 675 2.3e-69 Jerky protein homolog-like OS=Homo sapiens GN=JRKL PE=2 SV=2 PF05920//PF04218//PF03184 Homeobox KN domain//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- KOG3105 DNA-binding centromere protein B (CENP-B) Cluster-8309.7149 BP_3 130.46 3.19 2264 546681949 ERL91945.1 2152 4.3e-239 hypothetical protein D910_09268 [Dendroctonus ponderosae] 462361201 APGK01029141.1 87 4.42882e-35 Dendroctonus ponderosae Seq01029151, whole genome shotgun sequence -- -- -- -- Q50LG9 312 4.0e-27 Leucine-rich repeat-containing protein 24 OS=Homo sapiens GN=LRRC24 PE=2 SV=2 PF13895//PF13855//PF00560 Immunoglobulin domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.715 BP_3 1650.00 81.97 1262 91091226 XP_976093.1 356 4.3e-31 PREDICTED: uncharacterized protein LOC655629 [Tribolium castaneum]>gi|270013101|gb|EFA09549.1| hypothetical protein TcasGA2_TC011659 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7154 BP_3 57.67 0.61 4884 642927778 XP_008195402.1 1464 5.5e-159 PREDICTED: uncharacterized protein LOC658369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01484//PF04103//PF07690 Nematode cuticle collagen N-terminal domain//CD20-like family//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane -- -- Cluster-8309.7155 BP_3 109.21 1.20 4694 642927778 XP_008195402.1 2132 1.8e-236 PREDICTED: uncharacterized protein LOC658369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103//PF07690//PF07710 CD20-like family//Major Facilitator Superfamily//P53 tetramerisation motif GO:0051262//GO:0055085 protein tetramerization//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.7158 BP_3 4.00 0.63 598 828217891 XP_012560798.1 269 2.5e-21 PREDICTED: uncharacterized protein LOC101234332 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.716 BP_3 7.00 0.89 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7162 BP_3 4.00 0.70 567 478263695 ENN81998.1 139 2.8e-06 hypothetical protein YQE_01573, partial [Dendroctonus ponderosae]>gi|546677772|gb|ERL88548.1| hypothetical protein D910_05933 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7163 BP_3 10.00 1.03 760 478263695 ENN81998.1 459 2.9e-43 hypothetical protein YQE_01573, partial [Dendroctonus ponderosae]>gi|546677772|gb|ERL88548.1| hypothetical protein D910_05933 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05552 141 9.1e-08 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.717 BP_3 28.00 1.64 1114 270001339 EEZ97786.1 220 2.2e-15 odorant receptor 309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016020 membrane -- -- Cluster-8309.7170 BP_3 205.56 3.88 2846 546679820 ERL90212.1 1294 1.7e-139 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BQA5 823 2.8e-86 Histone H4 transcription factor OS=Homo sapiens GN=HINFP PE=1 SV=2 PF00096//PF13465//PF13912//PF07823 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Cyclic phosphodiesterase-like protein -- -- GO:0046872//GO:0004112 metal ion binding//cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.7171 BP_3 9.00 0.38 1432 758375323 AJO70002.1 2310 1.3e-257 V-ATPase A [Cherax destructor] 194861009 XM_001969660.1 457 0 Drosophila erecta GG23804 (Dere\GG23804), mRNA K02145 ATPeV1A, ATP6A V-type H+-transporting ATPase subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02145 Q90647 2034 5.3e-227 V-type proton ATPase catalytic subunit A OS=Gallus gallus GN=ATP6V1A PE=2 SV=1 PF00006//PF02874 ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta family, beta-barrel domain GO:0046034//GO:0015992 ATP metabolic process//proton transport GO:0005524 ATP binding -- -- KOG1352 Vacuolar H+-ATPase V1 sector, subunit A Cluster-8309.7172 BP_3 1.00 1.84 300 758375866 AJO70185.1 476 1.2e-45 V-H-ATPase subunit A [Cherax cainii] -- -- -- -- -- K02145 ATPeV1A, ATP6A V-type H+-transporting ATPase subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02145 P31400 410 2.3e-39 V-type proton ATPase catalytic subunit A OS=Manduca sexta GN=VHAA PE=2 SV=1 PF00306 ATP synthase alpha/beta chain, C terminal domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1352 Vacuolar H+-ATPase V1 sector, subunit A Cluster-8309.7174 BP_3 5.00 2.10 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7175 BP_3 24.00 0.94 1524 642918597 XP_008197482.1 177 3.0e-10 PREDICTED: pleckstrin homology domain-containing family G member 4B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.718 BP_3 6279.00 546.03 846 91087749 XP_974872.1 258 6.6e-20 PREDICTED: probable H/ACA ribonucleoprotein complex subunit 1 [Tribolium castaneum]>gi|270010737|gb|EFA07185.1| hypothetical protein TcasGA2_TC010191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7180 BP_3 7.06 0.42 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7183 BP_3 7.00 0.54 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.719 BP_3 49.49 0.76 3421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00018//PF08063//PF10588 SH3 domain//PADR1 (NUC008) domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114 oxidation-reduction process GO:0003950//GO:0016491//GO:0005515 NAD+ ADP-ribosyltransferase activity//oxidoreductase activity//protein binding GO:0005634 nucleus -- -- Cluster-8309.7190 BP_3 1.52 0.42 468 642913383 XP_969242.3 327 3.7e-28 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 184 5.7e-13 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF00326//PF01738 Prolyl oligopeptidase family//Dienelactone hydrolase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.7192 BP_3 9.00 0.70 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.72 BP_3 8.00 0.65 883 -- -- -- -- -- 51091849 AP006058.3 810 0 Oryza sativa Japonica Group genomic DNA, chromosome 9, BAC clone:OSJNBa0066B16 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7200 BP_3 13.73 0.41 1889 102939 426 4.9e-39 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P20825 246 1.5e-19 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF01114 Colipase, N-terminal domain GO:0007586//GO:0016042 digestion//lipid catabolic process GO:0008047 enzyme activator activity GO:0005576 extracellular region -- -- Cluster-8309.7201 BP_3 11.00 0.41 1583 14010625 AAK52058.1 1137 1.5e-121 RNA-directed DNA polymerase [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- P20825 1044 3.7e-112 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF05476 PET122 GO:0006417//GO:0006446//GO:0097034 regulation of translation//regulation of translational initiation//mitochondrial respiratory chain complex IV biogenesis GO:0003743 translation initiation factor activity GO:0005840//GO:0005743 ribosome//mitochondrial inner membrane -- -- Cluster-8309.7205 BP_3 27.22 1.30 1302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7209 BP_3 2.00 0.65 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7210 BP_3 80.92 6.23 918 642919236 XP_008191788.1 655 6.7e-66 PREDICTED: coiled-coil domain-containing protein 134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6E4 295 1.5e-25 Coiled-coil domain-containing protein 134 OS=Homo sapiens GN=CCDC134 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7212 BP_3 148.94 2.28 3445 546687691 ERL96264.1 1510 1.8e-164 hypothetical protein D910_01676 [Dendroctonus ponderosae] -- -- -- -- -- K02603 ORC1 origin recognition complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02603 O16810 1161 2.2e-125 Origin recognition complex subunit 1 OS=Drosophila melanogaster GN=Orc1 PE=1 SV=2 PF00004//PF05790 ATPase family associated with various cellular activities (AAA)//Immunoglobulin C2-set domain GO:0007155 cell adhesion GO:0005524 ATP binding GO:0016021 integral component of membrane KOG1514 Origin recognition complex, subunit 1, and related proteins Cluster-8309.7216 BP_3 4.00 0.70 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.722 BP_3 3.00 0.42 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7224 BP_3 148.76 1.66 4599 478254383 ENN74635.1 3286 0.0e+00 hypothetical protein YQE_08755, partial [Dendroctonus ponderosae] -- -- -- -- -- K02350 POLZ1, rev3 DNA polymerase zeta http://www.genome.jp/dbget-bin/www_bget?ko:K02350 Q61493 2447 2.2e-274 DNA polymerase zeta catalytic subunit OS=Mus musculus GN=Rev3l PE=1 SV=3 PF00136//PF03104 DNA polymerase family B//DNA polymerase family B, exonuclease domain -- -- GO:0003677//GO:0008408//GO:0000166 DNA binding//3'-5' exonuclease activity//nucleotide binding -- -- KOG0968 DNA polymerase zeta, catalytic subunit Cluster-8309.7226 BP_3 67.35 0.43 7788 478254383 ENN74635.1 1848 2.6e-203 hypothetical protein YQE_08755, partial [Dendroctonus ponderosae] -- -- -- -- -- K02350 POLZ1, rev3 DNA polymerase zeta http://www.genome.jp/dbget-bin/www_bget?ko:K02350 Q61493 1305 9.9e-142 DNA polymerase zeta catalytic subunit OS=Mus musculus GN=Rev3l PE=1 SV=3 PF13683//PF00136//PF03104//PF02741 Integrase core domain//DNA polymerase family B//DNA polymerase family B, exonuclease domain//FTR, proximal lobe GO:0006730//GO:0015074 one-carbon metabolic process//DNA integration GO:0008408//GO:0003677//GO:0016740//GO:0000166 3'-5' exonuclease activity//DNA binding//transferase activity//nucleotide binding -- -- KOG0968 DNA polymerase zeta, catalytic subunit Cluster-8309.7227 BP_3 1.00 1.16 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7228 BP_3 1.00 3.30 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7229 BP_3 19.00 0.98 1226 607354877 EZA49482.1 274 1.3e-21 hypothetical protein X777_12276 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7231 BP_3 5.00 0.37 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7232 BP_3 12.00 0.51 1431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07503//PF00641 HypF finger//Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.7238 BP_3 13.87 0.33 2303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11744 Aluminium activated malate transporter GO:0015743 malate transport -- -- -- -- -- -- Cluster-8309.724 BP_3 113.61 4.41 1534 270006762 EFA03210.1 351 2.0e-30 hypothetical protein TcasGA2_TC013130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 260 2.9e-21 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF04566 RNA polymerase Rpb2, domain 4 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.7243 BP_3 22.00 0.99 1359 478265967 ENN82639.1 215 1.0e-14 hypothetical protein YQE_00987, partial [Dendroctonus ponderosae]>gi|478265974|gb|ENN82644.1| hypothetical protein YQE_00985, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46108 152 8.6e-09 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.7245 BP_3 49.91 1.68 1724 478252288 ENN72715.1 415 8.5e-38 hypothetical protein YQE_10653, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5DU00 162 7.6e-10 Doublecortin domain-containing protein 2 OS=Mus musculus GN=Dcdc2 PE=2 SV=2 PF03607 Doublecortin GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.7247 BP_3 85.19 2.22 2145 478259368 ENN79267.1 1149 8.1e-123 hypothetical protein YQE_04302, partial [Dendroctonus ponderosae]>gi|478267667|gb|ENN83082.1| hypothetical protein YQE_00556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZU2 490 8.7e-48 Protein-cysteine N-palmitoyltransferase Rasp OS=Drosophila melanogaster GN=rasp PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3860 Acyltransferase required for palmitoylation of Hedgehog (Hh) family of secreted signaling proteins Cluster-8309.7249 BP_3 13.81 0.38 2037 546671336 ERL83691.1 1059 2.1e-112 hypothetical protein D910_00875 [Dendroctonus ponderosae]>gi|546677231|gb|ERL88104.1| hypothetical protein D910_05493 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZU2 451 2.8e-43 Protein-cysteine N-palmitoyltransferase Rasp OS=Drosophila melanogaster GN=rasp PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3860 Acyltransferase required for palmitoylation of Hedgehog (Hh) family of secreted signaling proteins Cluster-8309.7250 BP_3 35.91 1.77 1269 642911443 XP_008199425.1 1176 3.6e-126 PREDICTED: hydroxymethylglutaryl-CoA lyase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01640 E4.1.3.4, HMGCL, hmgL hydroxymethylglutaryl-CoA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01640 D4A5C3 941 2.6e-100 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic OS=Rattus norvegicus GN=Hmgcll1 PE=1 SV=1 PF00682 HMGL-like -- -- GO:0003824 catalytic activity -- -- KOG2368 Hydroxymethylglutaryl-CoA lyase Cluster-8309.7252 BP_3 22.41 0.64 1988 642919727 XP_970439.2 1152 3.4e-123 PREDICTED: guanylate cyclase soluble subunit beta-1 [Tribolium castaneum]>gi|642919729|ref|XP_008192041.1| PREDICTED: guanylate cyclase soluble subunit beta-1 [Tribolium castaneum] -- -- -- -- -- K12319 GUCY1B guanylate cyclase soluble subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12319 P20595 1000 5.9e-107 Guanylate cyclase soluble subunit beta-1 OS=Rattus norvegicus GN=Gucy1b3 PE=1 SV=2 PF07701//PF00211//PF08281 Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain//Sigma-70, region 4 GO:0006355//GO:0035556//GO:0006352//GO:0009190//GO:0006182//GO:0046039//GO:0006144 regulation of transcription, DNA-templated//intracellular signal transduction//DNA-templated transcription, initiation//cyclic nucleotide biosynthetic process//cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process GO:0004383//GO:0016987//GO:0016849//GO:0003700//GO:0003677 guanylate cyclase activity//sigma factor activity//phosphorus-oxygen lyase activity//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG4171 Adenylate/guanylate kinase Cluster-8309.7254 BP_3 9.46 0.47 1272 91082815 XP_968750.1 810 9.8e-84 PREDICTED: beta-galactoside alpha-2,6-sialyltransferase 1 [Tribolium castaneum]>gi|270007588|gb|EFA04036.1| hypothetical protein TcasGA2_TC014265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00777//PF01192 Glycosyltransferase family 29 (sialyltransferase)//RNA polymerase Rpb6 GO:0006206//GO:0006486//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//protein glycosylation//purine nucleobase metabolic process//transcription, DNA-templated GO:0008373//GO:0003677//GO:0003899 sialyltransferase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0030173 nucleolus//integral component of Golgi membrane -- -- Cluster-8309.7262 BP_3 46.37 2.26 1282 642927117 XP_008195144.1 934 4.1e-98 PREDICTED: clavesin-2 isoform X1 [Tribolium castaneum] 642927118 XM_967037.3 116 1.87514e-51 PREDICTED: Tribolium castaneum clavesin-2 (LOC660834), transcript variant X2, mRNA -- -- -- -- Q5M7E1 225 2.8e-17 Clavesin-1 OS=Xenopus laevis GN=clvs1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7264 BP_3 14.00 0.38 2072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7266 BP_3 25.04 2.83 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7267 BP_3 166.00 3.83 2381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7268 BP_3 150.37 5.91 1518 642922911 XP_008200448.1 295 6.1e-24 PREDICTED: glutenin, high molecular weight subunit DX5-like [Tribolium castaneum]>gi|270006551|gb|EFA02999.1| hypothetical protein TcasGA2_TC010421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11640 Telomere-length maintenance and DNA damage repair GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0004674 protein serine/threonine kinase activity -- -- -- -- Cluster-8309.727 BP_3 6.39 0.80 679 189239672 XP_001813945.1 456 5.9e-43 PREDICTED: serine proteinase stubble [Tribolium castaneum]>gi|270011208|gb|EFA07656.1| hypothetical protein TcasGA2_TC030609 [Tribolium castaneum] 642930385 XM_001813893.2 101 2.11503e-43 PREDICTED: Tribolium castaneum serine proteinase stubble (LOC662802), mRNA -- -- -- -- -- -- -- -- -- -- GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.7276 BP_3 1098.34 208.94 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01544//PF00242 CorA-like Mg2+ transporter protein//DNA polymerase (viral) N-terminal domain GO:0006260//GO:0055085//GO:0030001 DNA replication//transmembrane transport//metal ion transport GO:0046873//GO:0003887//GO:0003677 metal ion transmembrane transporter activity//DNA-directed DNA polymerase activity//DNA binding GO:0016020//GO:0042575 membrane//DNA polymerase complex -- -- Cluster-8309.7278 BP_3 16.00 0.37 2358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.728 BP_3 18830.00 3147.71 580 -- -- -- -- -- 462345819 APGK01034518.1 39 5.23069e-09 Dendroctonus ponderosae Seq01034528, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02535//PF01544//PF04513//PF15458 ZIP Zinc transporter//CorA-like Mg2+ transporter protein//Baculovirus polyhedron envelope protein, PEP, C terminus//Nineteen complex-related protein 2 GO:0030001//GO:0055085//GO:0000390 metal ion transport//transmembrane transport//spliceosomal complex disassembly GO:0005198//GO:0046873 structural molecule activity//metal ion transmembrane transporter activity GO:0071008//GO:0019028//GO:0019031//GO:0016020 U2-type post-mRNA release spliceosomal complex//viral capsid//viral envelope//membrane -- -- Cluster-8309.7281 BP_3 12.00 1.07 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7285 BP_3 3.00 0.92 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7288 BP_3 179.01 2.29 4059 270010437 EFA06885.1 2442 1.8e-272 hypothetical protein TcasGA2_TC009830 [Tribolium castaneum] 827546919 XM_004926175.2 138 3.56326e-63 PREDICTED: Bombyx mori protein prickle-like (LOC101737057), mRNA K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 A1Z6W3 1451 6.1e-159 Protein prickle OS=Drosophila melanogaster GN=pk PE=1 SV=1 PF01777//PF02529//PF00412//PF06297 Ribosomal L27e protein family//Cytochrome B6-F complex subunit 5//LIM domain//PET Domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0009512//GO:0005622//GO:0005840 cytochrome b6f complex//intracellular//ribosome KOG1704 FOG: LIM domain Cluster-8309.7290 BP_3 6.00 0.45 941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7293 BP_3 1.00 4.05 270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7294 BP_3 4.00 12.83 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7301 BP_3 1.00 0.43 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7302 BP_3 10.00 0.39 1520 646703582 KDR12193.1 1858 3.5e-205 Adenosylhomocysteinase [Zootermopsis nevadensis] 262401128 FJ774746.1 392 0 Scylla paramamosain adenosylhomocysteinase mRNA, partial cds K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 O76757 1826 7.4e-203 Adenosylhomocysteinase OS=Anopheles gambiae GN=Ahcy13 PE=2 SV=2 PF00208//PF13241//PF05221//PF02254//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Putative NAD(P)-binding//S-adenosyl-L-homocysteine hydrolase//TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0019354//GO:0006813//GO:0006730//GO:0055114//GO:0006555//GO:0006520//GO:0006779 siroheme biosynthetic process//potassium ion transport//one-carbon metabolic process//oxidation-reduction process//methionine metabolic process//cellular amino acid metabolic process//porphyrin-containing compound biosynthetic process GO:0043115//GO:0004013//GO:0051287//GO:0016491 precorrin-2 dehydrogenase activity//adenosylhomocysteinase activity//NAD binding//oxidoreductase activity -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.7308 BP_3 19.71 0.36 2961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7314 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.733 BP_3 6.00 0.44 952 665806284 XP_008551378.1 551 7.9e-54 PREDICTED: zinc finger BED domain-containing protein 5-like [Microplitis demolitor] 665806283 XM_008553156.1 194 6.02815e-95 PREDICTED: Microplitis demolitor zinc finger BED domain-containing protein 5-like (LOC103573897), mRNA -- -- -- -- A4Z944 279 1.1e-23 Zinc finger BED domain-containing protein 5 OS=Canis familiaris GN=ZBED5 PE=3 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.7331 BP_3 2.00 6.24 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7332 BP_3 14.00 0.50 1643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.734 BP_3 3946.37 380.98 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01018 GTP1/OBG -- -- GO:0005525 GTP binding -- -- -- -- Cluster-8309.7343 BP_3 8.00 0.41 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7345 BP_3 114.91 1.70 3558 642919458 XP_008191877.1 3114 0.0e+00 PREDICTED: gamma-tubulin complex component 2-like [Tribolium castaneum] -- -- -- -- -- K16569 TUBGCP2, GCP2 gamma-tubulin complex component 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16569 Q9BSJ2 1510 7.6e-166 Gamma-tubulin complex component 2 OS=Homo sapiens GN=TUBGCP2 PE=1 SV=2 PF04130 Spc97 / Spc98 family GO:0000226//GO:0090063 microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0000922//GO:0005815 spindle pole//microtubule organizing center KOG2001 Gamma-tubulin complex, DGRIP84/SPC97 component Cluster-8309.7347 BP_3 1.00 1.06 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7349 BP_3 10.00 0.31 1824 91084727 XP_970450.1 1794 1.1e-197 PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|642925824|ref|XP_008190453.1| PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|270008937|gb|EFA05385.1| hypothetical protein TcasGA2_TC015557 [Tribolium castaneum] 242000649 XM_002434923.1 66 1.67735e-23 Ixodes scapularis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.735 BP_3 140.63 1.80 4050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14984 CD24 protein GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.7354 BP_3 6.00 0.41 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.736 BP_3 1543.91 109.07 974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01771 Herpesvirus alkaline exonuclease -- -- GO:0004527//GO:0003677 exonuclease activity//DNA binding -- -- -- -- Cluster-8309.7360 BP_3 7.15 0.39 1177 189238464 XP_966906.2 248 1.3e-18 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q29RZ2 200 2.0e-14 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Bos taurus GN=PPWD1 PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.7362 BP_3 68.12 1.12 3213 189234308 XP_971839.2 1620 2.9e-177 PREDICTED: solute carrier family 35 member F3 [Tribolium castaneum] -- -- -- -- -- K15288 SLC35F3_4 solute carrier family 35, member F3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15288 Q1LZI2 436 2.4e-41 Putative thiamine transporter SLC35F3 OS=Mus musculus GN=Slc35f3 PE=2 SV=1 PF06027//PF00892 Solute carrier family 35//EamA-like transporter family GO:0006810 transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4314 Predicted carbohydrate/phosphate translocator Cluster-8309.7365 BP_3 528.56 4.46 6009 642919785 XP_008192065.1 3759 0.0e+00 PREDICTED: kinesin-like protein CG14535 isoform X2 [Tribolium castaneum] 759038090 XM_011353258.1 51 1.22046e-14 PREDICTED: Cerapachys biroi kinesin-like protein CG14535 (LOC105287618), mRNA K10404 KIF26 kinesin family member 26 http://www.genome.jp/dbget-bin/www_bget?ko:K10404 Q7TNC6 924 1.2e-97 Kinesin-like protein KIF26B OS=Mus musculus GN=Kif26b PE=1 SV=3 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.7372 BP_3 8.94 0.60 1015 270011004 EFA07452.1 422 7.7e-39 serine protease P91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 201 1.3e-14 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.7377 BP_3 31.00 4.55 620 642932244 XP_008197028.1 150 1.6e-07 PREDICTED: allatotropin I preprohormone isoform X1 [Tribolium castaneum]>gi|642932246|ref|XP_008197029.1| PREDICTED: allatotropin I preprohormone isoform X1 [Tribolium castaneum]>gi|642932248|ref|XP_008197030.1| PREDICTED: allatotropin I preprohormone isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03661 Uncharacterised protein family (UPF0121) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.7385 BP_3 35.00 1.54 1389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7386 BP_3 8.28 0.38 1344 91078782 XP_969464.1 827 1.1e-85 PREDICTED: differentially expressed in FDCP 8 homolog [Tribolium castaneum]>gi|270004105|gb|EFA00553.1| hypothetical protein TcasGA2_TC003420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTT9 381 2.4e-35 Differentially expressed in FDCP 8 homolog OS=Drosophila melanogaster GN=CG11534 PE=1 SV=1 PF04632//PF00130 Fusaric acid resistance protein family//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0006810 intracellular signal transduction//transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005886//GO:0005622 plasma membrane//intracellular -- -- Cluster-8309.7389 BP_3 13.00 0.87 1013 642932938 XP_008197195.1 931 7.3e-98 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q8BN82 446 5.2e-43 Sialin OS=Mus musculus GN=Slc17a5 PE=1 SV=2 PF07690//PF00083//PF03092 Major Facilitator Superfamily//Sugar (and other) transporter//BT1 family GO:0006810//GO:0055085 transport//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.739 BP_3 12.00 1.97 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05436 Mating factor alpha precursor N-terminus GO:0007618 mating -- -- GO:0005576 extracellular region -- -- Cluster-8309.7390 BP_3 3.18 0.37 703 642922652 XP_008193262.1 224 4.8e-16 PREDICTED: mediator of RNA polymerase II transcription subunit 15-like [Tribolium castaneum]>gi|270007150|gb|EFA03598.1| hypothetical protein TcasGA2_TC013685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17BA4 196 3.5e-14 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF09606//PF02172//PF16987 ARC105 or Med15 subunit of Mediator complex non-fungal//KIX domain//KIX domain GO:0006355//GO:0006357 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0003712//GO:0001104 transcription cofactor activity//RNA polymerase II transcription cofactor activity GO:0005667//GO:0016592 transcription factor complex//mediator complex -- -- Cluster-8309.7391 BP_3 118.00 2.70 2402 91081779 XP_973526.1 2481 3.2e-277 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005045|gb|EFA01493.1| hypothetical protein TcasGA2_TC007047 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 1271 2.7e-138 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF01061//PF13304//PF00005//PF03193//PF00004 ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA) GO:0006200 obsolete ATP catabolic process GO:0005525//GO:0005524//GO:0016887//GO:0003924 GTP binding//ATP binding//ATPase activity//GTPase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.7393 BP_3 4.00 1.66 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7398 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7408 BP_3 12.00 0.52 1408 478253705 ENN74004.1 354 8.2e-31 hypothetical protein YQE_09394, partial [Dendroctonus ponderosae]>gi|546678194|gb|ERL88884.1| hypothetical protein D910_06266 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O97398 257 6.0e-21 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.7412 BP_3 10.71 0.71 1020 91084301 XP_971859.1 539 2.1e-52 PREDICTED: structure-specific endonuclease subunit slx1 [Tribolium castaneum]>gi|270008803|gb|EFA05251.1| hypothetical protein TcasGA2_TC015403 [Tribolium castaneum] -- -- -- -- -- K15078 SLX1 structure-specific endonuclease subunit SLX1 http://www.genome.jp/dbget-bin/www_bget?ko:K15078 Q0IH86 408 1.3e-38 Structure-specific endonuclease subunit slx1 OS=Xenopus laevis GN=slx1a PE=2 SV=1 PF00628//PF00130//PF03119 PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//NAD-dependent DNA ligase C4 zinc finger domain GO:0006260//GO:0006281//GO:0035556 DNA replication//DNA repair//intracellular signal transduction GO:0003911//GO:0005515 DNA ligase (NAD+) activity//protein binding -- -- KOG3005 GIY-YIG type nuclease Cluster-8309.7413 BP_3 22.04 4.29 539 91092284 XP_968475.1 461 1.2e-43 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [Tribolium castaneum]>gi|270001209|gb|EEZ97656.1| hypothetical protein TcasGA2_TC016200 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q95JH2 158 6.9e-10 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Bos taurus GN=AGPAT1 PE=2 SV=1 PF01553 Acyltransferase GO:0008152//GO:0008654//GO:0046486//GO:0042967 metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane -- -- Cluster-8309.7415 BP_3 50.00 1.04 2617 642910360 XP_008200292.1 1575 4.0e-172 PREDICTED: protein MCM10 homolog [Tribolium castaneum] -- -- -- -- -- K10736 MCM10 minichromosome maintenance protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K10736 Q9VIE6 1158 3.7e-125 Protein MCM10 homolog OS=Drosophila melanogaster GN=Mcm10 PE=1 SV=2 PF09329 Primase zinc finger GO:0006260 DNA replication -- -- GO:0005634 nucleus KOG3056 Protein required for S-phase initiation or completion Cluster-8309.7426 BP_3 13.17 0.64 1284 91088619 XP_974054.1 986 3.9e-104 PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [Tribolium castaneum]>gi|270011691|gb|EFA08139.1| hypothetical protein TcasGA2_TC005756 [Tribolium castaneum] -- -- -- -- -- K00995 pgsA, PGS1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00995 Q5ZHN9 519 2.3e-51 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial OS=Gallus gallus GN=PGS1 PE=2 SV=1 PF00614 Phospholipase D Active site motif GO:0008654 phospholipid biosynthetic process GO:0003824//GO:0016780 catalytic activity//phosphotransferase activity, for other substituted phosphate groups -- -- KOG3964 Phosphatidylglycerolphosphate synthase Cluster-8309.7427 BP_3 48.78 1.33 2058 91088619 XP_974054.1 1243 9.8e-134 PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [Tribolium castaneum]>gi|270011691|gb|EFA08139.1| hypothetical protein TcasGA2_TC005756 [Tribolium castaneum] -- -- -- -- -- K00995 pgsA, PGS1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00995 Q32NB8 632 2.9e-64 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial OS=Homo sapiens GN=PGS1 PE=2 SV=1 PF00614 Phospholipase D Active site motif GO:0008654 phospholipid biosynthetic process GO:0003824//GO:0016780 catalytic activity//phosphotransferase activity, for other substituted phosphate groups -- -- KOG3964 Phosphatidylglycerolphosphate synthase Cluster-8309.7434 BP_3 88.00 0.89 5070 642938249 XP_008198129.1 1810 4.3e-199 PREDICTED: CUGBP Elav-like family member 4 [Tribolium castaneum] 642938248 XM_008199907.1 866 0 PREDICTED: Tribolium castaneum CUGBP Elav-like family member 4 (LOC659679), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q6DGV1 1071 8.8e-115 CUGBP Elav-like family member 4 OS=Danio rerio GN=celf4 PE=2 SV=1 PF08777//PF08675//PF00076//PF16367 RNA binding motif//RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.7435 BP_3 77.00 1.81 2339 765147862 XP_011484596.1 765 3.0e-78 PREDICTED: zinc finger protein 883-like [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 702 2.5e-72 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF07776//PF16622//PF13912//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.7438 BP_3 28.00 0.64 2404 478257368 ENN77526.1 1405 1.9e-152 hypothetical protein YQE_05974, partial [Dendroctonus ponderosae]>gi|546685339|gb|ERL94866.1| hypothetical protein D910_12139 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PDX6 363 5.2e-33 E3 ubiquitin-protein ligase Rnf220 OS=Mus musculus GN=Rnf220 PE=1 SV=1 PF14634//PF12861//PF15926//PF00097//PF11789//PF13639 zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//E3 ubiquitin-protein ligase RNF220//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Ring finger domain GO:0090263//GO:0016567 positive regulation of canonical Wnt signaling pathway//protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.744 BP_3 19.69 1.22 1071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7442 BP_3 9.16 0.31 1735 91090700 XP_974799.1 941 8.6e-99 PREDICTED: Bardet-Biedl syndrome 1 protein [Tribolium castaneum]>gi|270013946|gb|EFA10394.1| hypothetical protein TcasGA2_TC012625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFJ9 406 3.9e-38 Bardet-Biedl syndrome 1 protein OS=Homo sapiens GN=BBS1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7443 BP_3 2.00 0.78 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7450 BP_3 84.79 2.60 1864 625273553 XP_007628351.1 527 9.4e-51 PREDICTED: zinc finger protein 883-like isoform X5 [Cricetulus griseus] -- -- -- -- -- -- -- -- -- Q5XIU2 811 4.5e-85 Zinc finger protein 143 OS=Rattus norvegicus GN=Znf143 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.7451 BP_3 12.00 0.48 1487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7453 BP_3 50.15 1.25 2220 270002290 EEZ98737.1 2304 9.9e-257 hypothetical protein TcasGA2_TC001292 [Tribolium castaneum] -- -- -- -- -- K03352 APC5 anaphase-promoting complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03352 Q9UJX4 829 4.4e-87 Anaphase-promoting complex subunit 5 OS=Homo sapiens GN=ANAPC5 PE=1 SV=2 PF13181//PF00515//PF07721//PF13374//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG4322 Anaphase-promoting complex (APC), subunit 5 Cluster-8309.746 BP_3 108.00 1.67 3411 546680431 ERL90697.1 508 2.8e-48 hypothetical protein D910_08044 [Dendroctonus ponderosae] 820857085 XM_012490229.1 104 2.37721e-44 PREDICTED: Apis florea dual specificity tyrosine-phosphorylation-regulated kinase 1A-like (LOC105736299), mRNA K09083 ATOH1_7 atonal protein 1/7 http://www.genome.jp/dbget-bin/www_bget?ko:K09083 Q5IS79 161 2.0e-09 Protein atonal homolog 1 OS=Pan troglodytes GN=ATOH1 PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.7468 BP_3 5.00 0.40 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7470 BP_3 9.16 0.42 1355 752886654 XP_011261164.1 160 2.5e-08 PREDICTED: uncharacterized protein LOC105254296 isoform X2 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7474 BP_3 96.00 2.76 1968 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7476 BP_3 3.00 1.46 389 607359213 EZA53585.1 158 1.2e-08 hypothetical protein X777_06941 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7477 BP_3 132.00 2.29 3066 546680335 ERL90621.1 1358 6.8e-147 hypothetical protein D910_07968 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54B37 280 2.8e-23 RhoGEF domain-containing protein gxcJ OS=Dictyostelium discoideum GN=gxcJ PE=3 SV=1 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3 Cluster-8309.7479 BP_3 4.00 0.55 645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7481 BP_3 52.73 0.63 4351 189235221 XP_967494.2 258 3.4e-19 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15047 HNRNPUL1, E1BAP5 heterogeneous nuclear ribonucleoprotein U-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15047 Q9BUJ2 173 1.0e-10 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens GN=HNRNPUL1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7487 BP_3 2.00 0.38 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7488 BP_3 90.52 5.19 1133 478259751 ENN79592.1 1082 2.5e-115 hypothetical protein YQE_03963, partial [Dendroctonus ponderosae]>gi|546678748|gb|ERL89300.1| hypothetical protein D910_06672 [Dendroctonus ponderosae] -- -- -- -- -- K14302 NUP37 nuclear pore complex protein Nup37 http://www.genome.jp/dbget-bin/www_bget?ko:K14302 Q9CWU9 431 3.2e-41 Nucleoporin Nup37 OS=Mus musculus GN=Nup37 PE=2 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.7489 BP_3 7.00 0.33 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.749 BP_3 13.35 0.89 1015 642930950 XP_008196154.1 149 3.5e-07 PREDICTED: transmembrane protein 145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7490 BP_3 112.00 8.68 914 270010333 EFA06781.1 579 4.3e-57 hypothetical protein TcasGA2_TC009717, partial [Tribolium castaneum] -- -- -- -- -- K12599 SKI2, SKIV2L antiviral helicase SKI2 http://www.genome.jp/dbget-bin/www_bget?ko:K12599 Q15477 220 7.5e-17 Helicase SKI2W OS=Homo sapiens GN=SKIV2L PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7491 BP_3 50.50 1.56 1849 641681639 XP_008189542.1 961 4.4e-101 PREDICTED: uncharacterized protein LOC103311641 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.7493 BP_3 190.00 6.08 1797 270014420 EFA10868.1 337 9.8e-29 hypothetical protein TcasGA2_TC001689 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7P9 192 2.6e-13 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.7495 BP_3 7.00 4.10 371 195026146 XP_001986192.1 201 1.2e-13 GH21223 [Drosophila grimshawi]>gi|193902192|gb|EDW01059.1| GH21223 [Drosophila grimshawi] 262401214 FJ774789.1 182 1.0403e-88 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7500 BP_3 15.91 1.69 745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7501 BP_3 81.52 1.36 3191 478260698 ENN80386.1 1173 2.0e-125 hypothetical protein YQE_03188, partial [Dendroctonus ponderosae] -- -- -- -- -- K10398 KIF11, EG5 kinesin family member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10398 P46863 1043 9.7e-112 Bipolar kinesin KRP-130 OS=Drosophila melanogaster GN=Klp61F PE=1 SV=2 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0003777//GO:0008017//GO:0005524 microtubule motor activity//microtubule binding//ATP binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG0243 Kinesin-like protein Cluster-8309.7505 BP_3 10.00 1.22 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7506 BP_3 5582.71 307.78 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7507 BP_3 143.12 4.29 1901 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7511 BP_3 7.00 0.53 926 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7514 BP_3 3.06 0.42 646 642918952 XP_974118.3 279 1.9e-22 PREDICTED: protein king tubby [Tribolium castaneum]>gi|270005704|gb|EFA02152.1| hypothetical protein TcasGA2_TC007804 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86PC9 176 6.7e-12 Protein king tubby OS=Drosophila melanogaster GN=ktub PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7523 BP_3 12.00 0.44 1596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07710 P53 tetramerisation motif GO:0051262 protein tetramerization -- -- -- -- -- -- Cluster-8309.7526 BP_3 5.00 0.79 595 478250472 ENN70967.1 285 3.5e-23 hypothetical protein YQE_12368, partial [Dendroctonus ponderosae] -- -- -- -- -- K05746 ENAH, MENA enabled http://www.genome.jp/dbget-bin/www_bget?ko:K05746 Q8T4F7 239 3.1e-19 Protein enabled OS=Drosophila melanogaster GN=ena PE=1 SV=4 -- -- -- -- -- -- -- -- KOG4590 Signal transduction protein Enabled, contains WH1 domain Cluster-8309.753 BP_3 34.00 0.45 3913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7535 BP_3 4.00 0.36 829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7539 BP_3 45.04 1.05 2367 642930197 XP_008196297.1 3087 0.0e+00 PREDICTED: protein jagged-1b isoform X2 [Tribolium castaneum] 642930196 XM_008198075.1 620 0 PREDICTED: Tribolium castaneum protein jagged-1b (LOC652942), transcript variant X2, mRNA K06052 JAGGED jagged http://www.genome.jp/dbget-bin/www_bget?ko:K06052 Q9QXX0 1796 3.5e-199 Protein jagged-1 OS=Mus musculus GN=Jag1 PE=1 SV=1 PF01414//PF07657//PF00008//PF07645 Delta serrate ligand//N terminus of Notch ligand//EGF-like domain//Calcium-binding EGF domain GO:0007219//GO:0007275//GO:0007154 Notch signaling pathway//multicellular organismal development//cell communication GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.7540 BP_3 147.53 1.46 5147 642930195 XP_008196296.1 5033 0.0e+00 PREDICTED: protein jagged-1b isoform X1 [Tribolium castaneum] 642930196 XM_008198075.1 617 0 PREDICTED: Tribolium castaneum protein jagged-1b (LOC652942), transcript variant X2, mRNA K06052 JAGGED jagged http://www.genome.jp/dbget-bin/www_bget?ko:K06052 Q9QYE5 2335 2.4e-261 Protein jagged-2 OS=Mus musculus GN=Jag2 PE=2 SV=2 PF00008//PF07645//PF01414//PF07657 EGF-like domain//Calcium-binding EGF domain//Delta serrate ligand//N terminus of Notch ligand GO:0007154//GO:0007275//GO:0007219 cell communication//multicellular organismal development//Notch signaling pathway GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.7541 BP_3 19.34 0.34 3047 665816551 XP_008556999.1 615 9.6e-61 PREDICTED: fatty acid synthase-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P19096 388 8.3e-36 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.7556 BP_3 17.69 1.26 967 91091178 XP_971714.1 453 1.9e-42 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q9EPL9 308 5.0e-27 Peroxisomal acyl-coenzyme A oxidase 3 OS=Mus musculus GN=Acox3 PE=1 SV=2 PF01756//PF00441 Acyl-CoA oxidase//Acyl-CoA dehydrogenase, C-terminal domain GO:0006635//GO:0055114//GO:0006637//GO:0044710 fatty acid beta-oxidation//oxidation-reduction process//acyl-CoA metabolic process//single-organism metabolic process GO:0016627//GO:0003997 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.7557 BP_3 67.00 2.44 1614 546675817 ERL86930.1 1485 6.7e-162 hypothetical protein D910_04333 [Dendroctonus ponderosae] -- -- -- -- -- K13118 DGCR14 protein DGCR14 http://www.genome.jp/dbget-bin/www_bget?ko:K13118 O44424 839 2.2e-88 Protein DGCR14 homolog OS=Drosophila melanogaster GN=Es2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2627 Nuclear protein ES2 Cluster-8309.757 BP_3 5.00 0.35 973 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7575 BP_3 6.00 0.37 1069 641648626 XP_008182912.1 590 2.7e-58 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6AZB8 236 1.2e-18 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity -- -- -- -- Cluster-8309.7578 BP_3 3.00 0.34 714 642932810 XP_008196994.1 242 4.0e-18 PREDICTED: protein CLEC16A isoform X2 [Tribolium castaneum]>gi|270011483|gb|EFA07931.1| hypothetical protein TcasGA2_TC005512 [Tribolium castaneum] -- -- -- -- -- K19513 CLEC16A protein CLEC16A http://www.genome.jp/dbget-bin/www_bget?ko:K19513 Q2KHT3 168 6.3e-11 Protein CLEC16A OS=Homo sapiens GN=CLEC16A PE=2 SV=2 PF03789 ELK domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.758 BP_3 14.00 0.32 2412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7582 BP_3 8.00 0.79 779 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.759 BP_3 3.00 0.67 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7590 BP_3 42.21 1.77 1440 642920799 XP_008192566.1 727 4.7e-74 PREDICTED: caltractin isoform X1 [Tribolium castaneum] 2920834 U92973.1 100 1.65651e-42 MVU92973 Marsilea vestita centrin (MvCen1) mRNA, complete cds K10840 CETN2 centrin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10840 Q32LE3 659 1.5e-67 Centrin-1 OS=Bos taurus GN=CETN1 PE=2 SV=1 PF13202//PF00036//PF12763//PF00298//PF13499//PF10591//PF13833//PF13405 EF hand//EF hand//Cytoskeletal-regulatory complex EF hand//Ribosomal protein L11, RNA binding domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0006412//GO:0007165//GO:0042254 translation//signal transduction//ribosome biogenesis GO:0005515//GO:0003735//GO:0005509 protein binding//structural constituent of ribosome//calcium ion binding GO:0005840//GO:0005578 ribosome//proteinaceous extracellular matrix KOG0028 Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein Cluster-8309.7591 BP_3 225.79 8.32 1600 642920799 XP_008192566.1 727 5.2e-74 PREDICTED: caltractin isoform X1 [Tribolium castaneum] 2920834 U92973.1 100 1.84515e-42 MVU92973 Marsilea vestita centrin (MvCen1) mRNA, complete cds K10840 CETN2 centrin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10840 Q32LE3 659 1.6e-67 Centrin-1 OS=Bos taurus GN=CETN1 PE=2 SV=1 PF13202//PF00036//PF00298//PF12763//PF13499//PF10591//PF13833//PF13405 EF hand//EF hand//Ribosomal protein L11, RNA binding domain//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0006412//GO:0007165//GO:0042254 translation//signal transduction//ribosome biogenesis GO:0005515//GO:0005509//GO:0003735 protein binding//calcium ion binding//structural constituent of ribosome GO:0005578//GO:0005840 proteinaceous extracellular matrix//ribosome KOG0028 Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein Cluster-8309.7592 BP_3 33.75 0.83 2249 91075996 XP_970892.1 1021 5.9e-108 PREDICTED: probable protein-cysteine N-palmitoyltransferase porcupine [Tribolium castaneum]>gi|270014667|gb|EFA11115.1| hypothetical protein TcasGA2_TC004714 [Tribolium castaneum] -- -- -- -- -- K00181 PPN porcupine http://www.genome.jp/dbget-bin/www_bget?ko:K00181 Q7Q3N5 528 3.6e-52 Protein-serine O-palmitoleoyltransferase porcupine OS=Anopheles gambiae GN=por PE=3 SV=1 PF06422 CDR ABC transporter GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG4312 Predicted acyltransferase Cluster-8309.7593 BP_3 187.12 5.29 1997 91075996 XP_970892.1 1229 4.0e-132 PREDICTED: probable protein-cysteine N-palmitoyltransferase porcupine [Tribolium castaneum]>gi|270014667|gb|EFA11115.1| hypothetical protein TcasGA2_TC004714 [Tribolium castaneum] -- -- -- -- -- K00181 PPN porcupine http://www.genome.jp/dbget-bin/www_bget?ko:K00181 Q7Q3N5 557 1.4e-55 Protein-serine O-palmitoleoyltransferase porcupine OS=Anopheles gambiae GN=por PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4312 Predicted acyltransferase Cluster-8309.7594 BP_3 14.13 0.34 2306 91075996 XP_970892.1 1021 6.1e-108 PREDICTED: probable protein-cysteine N-palmitoyltransferase porcupine [Tribolium castaneum]>gi|270014667|gb|EFA11115.1| hypothetical protein TcasGA2_TC004714 [Tribolium castaneum] -- -- -- -- -- K00181 PPN porcupine http://www.genome.jp/dbget-bin/www_bget?ko:K00181 Q7Q3N5 528 3.7e-52 Protein-serine O-palmitoleoyltransferase porcupine OS=Anopheles gambiae GN=por PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4312 Predicted acyltransferase Cluster-8309.7597 BP_3 5.00 0.39 904 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7604 BP_3 413.00 13.21 1799 642929057 XP_008195673.1 1028 7.3e-109 PREDICTED: dimethyladenosine transferase 2, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VH38 413 6.2e-39 Dimethyladenosine transferase 2, mitochondrial OS=Drosophila melanogaster GN=mtTFB2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7606 BP_3 22.48 0.59 2118 642929450 XP_008195846.1 2631 1.1e-294 PREDICTED: serine/threonine-protein kinase D3 isoform X2 [Tribolium castaneum] 242010804 XM_002426104.1 76 5.39179e-29 Pediculus humanus corporis serine/threonine-protein kinase D1, putative, mRNA K06070 PKD protein kinase D http://www.genome.jp/dbget-bin/www_bget?ko:K06070 O94806 1462 1.7e-160 Serine/threonine-protein kinase D3 OS=Homo sapiens GN=PRKD3 PE=1 SV=1 PF00069//PF16866//PF07714//PF00628//PF07649//PF00130//PF01155 Protein kinase domain//PHD-finger//Protein tyrosine kinase//PHD-finger//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0035556//GO:0055114//GO:0006468//GO:0006464 intracellular signal transduction//oxidation-reduction process//protein phosphorylation//cellular protein modification process GO:0047134//GO:0004672//GO:0005515//GO:0016151//GO:0005524 protein-disulfide reductase activity//protein kinase activity//protein binding//nickel cation binding//ATP binding -- -- KOG4236 Serine/threonine protein kinase PKC mu/PKD and related proteins Cluster-8309.7607 BP_3 105.00 2.67 2184 641647727 XP_008179395.1 882 7.5e-92 PREDICTED: jerky protein homolog-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03172//PF03184 Sp100 domain//DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.7617 BP_3 7.00 0.39 1164 -- -- -- -- -- 462339182 APGK01036910.1 43 6.46155e-11 Dendroctonus ponderosae Seq01036920, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7618 BP_3 11.00 0.49 1370 91092970 XP_967107.1 1169 2.5e-125 PREDICTED: tektin-2 [Tribolium castaneum]>gi|270003167|gb|EEZ99614.1| hypothetical protein TcasGA2_TC002132 [Tribolium castaneum] -- -- -- -- -- K18629 TEKT2 tektin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K18629 Q26648 413 4.7e-39 Tektin-B1 OS=Strongylocentrotus purpuratus PE=1 SV=1 PF07926//PF03938 TPR/MLP1/MLP2-like protein//Outer membrane protein (OmpH-like) GO:0000226//GO:0006606 microtubule cytoskeleton organization//protein import into nucleus GO:0051082 unfolded protein binding GO:0005874 microtubule -- -- Cluster-8309.7627 BP_3 16.00 1.19 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7636 BP_3 7.00 1.76 483 357607249 EHJ65404.1 312 2.1e-26 hypothetical protein KGM_05439 [Danaus plexippus] -- -- -- -- -- K00418 QCR8, UQCRQ ubiquinol-cytochrome c reductase subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K00418 Q9CQ69 238 3.3e-19 Cytochrome b-c1 complex subunit 8 OS=Mus musculus GN=Uqcrq PE=1 SV=3 PF02939 UcrQ family GO:0006118//GO:0015992//GO:0006119 obsolete electron transport//proton transport//oxidative phosphorylation GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- KOG4116 Ubiquinol cytochrome c reductase, subunit QCR8 Cluster-8309.7639 BP_3 46.33 0.60 4010 546681139 ERL91289.1 1194 9.2e-128 hypothetical protein D910_08622 [Dendroctonus ponderosae] -- -- -- -- -- K10865 MRE11 double-strand break repair protein MRE11 http://www.genome.jp/dbget-bin/www_bget?ko:K10865 Q9W6K1 940 1.1e-99 Double-strand break repair protein MRE11 OS=Xenopus laevis GN=mre11 PE=2 SV=1 PF00614//PF00149//PF04152//PF09003 Phospholipase D Active site motif//Calcineurin-like phosphoesterase//Mre11 DNA-binding presumed domain//Bacteriophage lambda integrase, N-terminal domain GO:0015074//GO:0006302 DNA integration//double-strand break repair GO:0008907//GO:0030145//GO:0004519//GO:0003824//GO:0003677//GO:0016787 integrase activity//manganese ion binding//endonuclease activity//catalytic activity//DNA binding//hydrolase activity GO:0005634 nucleus KOG2310 DNA repair exonuclease MRE11 Cluster-8309.7644 BP_3 3.00 0.38 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7645 BP_3 4.00 0.41 760 478262664 ENN81216.1 448 5.5e-42 hypothetical protein YQE_02376, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NBX4 329 1.4e-29 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7649 BP_3 1.00 0.39 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7656 BP_3 357.00 6.68 2867 642920314 XP_008192295.1 581 7.9e-57 PREDICTED: uncharacterized protein LOC103312702 [Tribolium castaneum]>gi|270006053|gb|EFA02501.1| hypothetical protein TcasGA2_TC008197 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7657 BP_3 43.00 17.22 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7659 BP_3 487.91 3.29 7450 591350379 XP_007069726.1 598 2.2e-58 PREDICTED: zinc finger protein 850-like [Chelonia mydas] 642917654 XM_008195282.1 379 0 PREDICTED: Tribolium castaneum zinc finger protein 502 (LOC100141877), mRNA -- -- -- -- P28698 556 6.7e-55 Myeloid zinc finger 1 OS=Homo sapiens GN=MZF1 PE=1 SV=3 PF13912//PF01429//PF16622//PF06350//PF00096//PF13465//PF01155 C2H2-type zinc finger//Methyl-CpG binding domain//zinc-finger C2H2-type//Hormone-sensitive lipase (HSL) N-terminus//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0008203//GO:0006464//GO:0016042 cholesterol metabolic process//cellular protein modification process//lipid catabolic process GO:0016151//GO:0003677//GO:0046872//GO:0016298 nickel cation binding//DNA binding//metal ion binding//lipase activity GO:0005634 nucleus -- -- Cluster-8309.766 BP_3 36.00 1.38 1545 831276288 XP_012695575.1 483 9.9e-46 PREDICTED: zinc finger protein ZIC 1-like [Clupea harengus] -- -- -- -- -- K09232 GLIS1_3 zinc finger protein GLIS1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09232 Q8NEA6 675 2.2e-69 Zinc finger protein GLIS3 OS=Homo sapiens GN=GLIS3 PE=2 SV=5 PF13465//PF00096//PF16622//PF11851 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//Domain of unknown function (DUF3371) GO:0006355 regulation of transcription, DNA-templated GO:0046872 metal ion binding -- -- -- -- Cluster-8309.7664 BP_3 7.13 0.77 740 332376491 AEE63385.1 519 3.2e-50 unknown [Dendroctonus ponderosae]>gi|546680485|gb|ERL90751.1| hypothetical protein D910_08098 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7RUD5 457 2.0e-44 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Nematostella vectensis GN=v1g236650 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.7666 BP_3 129.00 4.73 1605 281427796 NP_001164000.1 1157 7.2e-124 aurora kinase A [Tribolium castaneum]>gi|270015978|gb|EFA12426.1| aurora kinase A [Tribolium castaneum] 769863409 XM_011645254.1 103 3.97856e-44 PREDICTED: Pogonomyrmex barbatus aurora kinase C-like (LOC105431214), transcript variant X3, mRNA K11481 AURKA aurora kinase A http://www.genome.jp/dbget-bin/www_bget?ko:K11481 Q91820 1028 2.7e-110 Aurora kinase A-A OS=Xenopus laevis GN=aurka-a PE=1 SV=1 PF00069//PF00735//PF06293//PF07714 Protein kinase domain//Septin//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004674//GO:0004672//GO:0016773//GO:0005525 ATP binding//protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//GTP binding GO:0016020 membrane KOG0580 Serine/threonine protein kinase Cluster-8309.767 BP_3 14.00 1.75 677 270009361 EFA05809.1 141 2.0e-06 hypothetical protein TcasGA2_TC030749 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7672 BP_3 6.00 0.58 787 501294359 BAN20719.1 205 8.7e-14 conserved hypothetical protein [Riptortus pedestris] 392303569 JX102602.1 127 8.69423e-58 Scylla paramamosain microsatellite Spm31 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7674 BP_3 7.07 0.41 1130 478254108 ENN74392.1 397 6.8e-36 hypothetical protein YQE_09010, partial [Dendroctonus ponderosae] -- -- -- -- -- K11375 ELP4 elongator complex protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11375 Q5XG58 221 7.1e-17 Elongator complex protein 4 OS=Xenopus laevis GN=elp4 PE=2 SV=1 PF05625 PAXNEB protein -- -- -- -- GO:0033588 Elongator holoenzyme complex -- -- Cluster-8309.7680 BP_3 6.00 0.43 972 66811940 XP_640149.1 509 6.0e-49 40S ribosomal protein S11 [Dictyostelium discoideum AX4]>gi|74854958|sp|Q54S90.1|RS11_DICDI RecName: Full=40S ribosomal protein S11>gi|60468150|gb|EAL66160.1| 40S ribosomal protein S11 [Dictyostelium discoideum AX4] 697066056 XM_009649920.1 831 0 Verticillium dahliae VdLs.17 40S ribosomal protein S11 mRNA K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P0CT74 608 8.2e-62 40S ribosomal protein S11-B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rps1102 PE=3 SV=1 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.7681 BP_3 25.00 1.78 969 635015808 XP_008007775.1 1058 1.3e-112 PREDICTED: LOW QUALITY PROTEIN: ferritin heavy chain [Chlorocebus sabaeus] 56682958 NM_002032.2 942 0 Homo sapiens ferritin, heavy polypeptide 1 (FTH1), mRNA K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 P02794 968 1.5e-103 Ferritin heavy chain OS=Homo sapiens GN=FTH1 PE=1 SV=2 PF02915//PF10399//PF00210//PF02387 Rubrerythrin//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//Ferritin-like domain//IncFII RepA protein family GO:0006879//GO:0006276//GO:0006119//GO:0006118//GO:0055114//GO:0015992 cellular iron ion homeostasis//plasmid maintenance//oxidative phosphorylation//obsolete electron transport//oxidation-reduction process//proton transport GO:0008121//GO:0016491//GO:0008199//GO:0046872 ubiquinol-cytochrome-c reductase activity//oxidoreductase activity//ferric iron binding//metal ion binding -- -- -- -- Cluster-8309.7683 BP_3 4.00 0.47 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00779 BTK motif GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.7686 BP_3 3.43 0.40 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7699 BP_3 15.79 0.49 1855 478249887 ENN70394.1 825 2.6e-85 hypothetical protein YQE_12900, partial [Dendroctonus ponderosae]>gi|546683393|gb|ERL93212.1| hypothetical protein D910_10508 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BZD2 379 5.6e-35 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.770 BP_3 13.00 4.30 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7702 BP_3 23.34 0.31 3959 642925330 XP_008194509.1 2130 2.6e-236 PREDICTED: codanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CC12 901 3.5e-95 Codanin-1 OS=Mus musculus GN=Cdan1 PE=2 SV=2 PF09328//PF12920 Domain of unknown function (DUF1984)//TcdA/TcdB pore forming domain GO:0010038//GO:0009405//GO:0046938 response to metal ion//pathogenesis//phytochelatin biosynthetic process GO:0016756//GO:0046872 glutathione gamma-glutamylcysteinyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.771 BP_3 17.00 0.91 1196 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7710 BP_3 27.52 1.20 1396 642923162 XP_968605.2 1601 2.0e-175 PREDICTED: O-glucosyltransferase rumi homolog [Tribolium castaneum]>gi|270007100|gb|EFA03548.1| hypothetical protein TcasGA2_TC013552 [Tribolium castaneum] -- -- -- -- -- K13667 RUMI, KTELC1 protein glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13667 Q16QY8 1255 1.1e-136 O-glucosyltransferase rumi homolog OS=Aedes aegypti GN=AAEL011121 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2458 Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif Cluster-8309.7717 BP_3 24.46 1.81 943 642927913 XP_008195445.1 591 1.8e-58 PREDICTED: tRNA selenocysteine 1-associated protein 1 isoform X1 [Tribolium castaneum]>gi|270010282|gb|EFA06730.1| hypothetical protein TcasGA2_TC009661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NX07 291 4.5e-25 tRNA selenocysteine 1-associated protein 1 OS=Homo sapiens GN=TRNAU1AP PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG0118 FOG: RRM domain Cluster-8309.7718 BP_3 11.12 0.84 931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.772 BP_3 11.27 0.96 860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7723 BP_3 1.06 0.47 398 478256092 ENN76291.1 150 1.0e-07 hypothetical protein YQE_07254, partial [Dendroctonus ponderosae]>gi|546675832|gb|ERL86937.1| hypothetical protein D910_04339 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7730 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7731 BP_3 419.66 5.03 4315 642917872 XP_969181.2 271 1.1e-20 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7B4 153 2.1e-08 Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens GN=SMYD3 PE=1 SV=4 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.7732 BP_3 21.40 2.27 747 91080835 XP_970786.1 779 2.3e-80 PREDICTED: vacuolar-sorting protein SNF8 [Tribolium castaneum]>gi|642919734|ref|XP_008192042.1| PREDICTED: vacuolar-sorting protein SNF8 [Tribolium castaneum]>gi|270005419|gb|EFA01867.1| hypothetical protein TcasGA2_TC007472 [Tribolium castaneum] -- -- -- -- -- K12188 SNF8, EAP30 ESCRT-II complex subunit VPS22 http://www.genome.jp/dbget-bin/www_bget?ko:K12188 Q96H20 545 1.3e-54 Vacuolar-sorting protein SNF8 OS=Homo sapiens GN=SNF8 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3341 RNA polymerase II transcription factor complex subunit Cluster-8309.7734 BP_3 26.00 1.15 1382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.774 BP_3 3.00 0.67 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7744 BP_3 5.27 0.59 724 642929699 XP_008195940.1 488 1.2e-46 PREDICTED: 28S ribosomal protein S18a, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02963 RP-S18, MRPS18, rpsR small subunit ribosomal protein S18 http://www.genome.jp/dbget-bin/www_bget?ko:K02963 Q9NVS2 153 3.5e-09 28S ribosomal protein S18a, mitochondrial OS=Homo sapiens GN=MRPS18A PE=1 SV=1 PF01084 Ribosomal protein S18 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3162 Mitochondrial/chloroplast ribosomal protein S18 Cluster-8309.7745 BP_3 6.00 0.40 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7747 BP_3 7.00 0.86 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7751 BP_3 2.00 0.41 529 -- -- -- -- -- 631798738 KJ522777.1 74 1.65798e-28 Propylea japonica beta-actin mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7756 BP_3 2.48 0.70 463 546674358 ERL85745.1 216 2.7e-15 hypothetical protein D910_03160 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P00771 170 2.4e-11 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.7763 BP_3 316.41 2.95 5460 642930393 XP_008196379.1 2168 1.4e-240 PREDICTED: uncharacterized protein LOC662968 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 477 7.1e-46 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.7765 BP_3 6.00 0.54 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7768 BP_3 9.56 0.40 1449 646695057 KDR08231.1 174 6.3e-10 hypothetical protein L798_01949 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7772 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7774 BP_3 25.04 0.56 2455 642911640 XP_008200682.1 1107 6.9e-118 PREDICTED: protein RRNAD1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9V4 471 1.6e-45 Protein RRNAD1 OS=Bos taurus GN=RRNAD1 PE=2 SV=1 PF08123 Histone methylation protein DOT1 GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0018024 histone-lysine N-methyltransferase activity -- -- KOG2651 rRNA adenine N-6-methyltransferase Cluster-8309.7776 BP_3 4.00 0.37 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7777 BP_3 5.00 1.35 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7778 BP_3 3.00 1.15 416 246372819 ABL10360.2 615 1.3e-61 voltage-gated sodium channel [Cancer borealis] 246372818 EF089568.2 308 1.06764e-158 Cancer borealis voltage-gated sodium channel mRNA, complete cds K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 P35500 526 1.1e-52 Sodium channel protein para OS=Drosophila melanogaster GN=para PE=2 SV=3 PF06112//PF00520//PF02066 Gammaherpesvirus capsid protein//Ion transport protein//Metallothionein family 11 GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216//GO:0005507 ion channel activity//copper ion binding GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-8309.7783 BP_3 15.01 1.00 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7784 BP_3 85.82 1.06 4205 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7785 BP_3 183.00 6.96 1559 478258633 ENN78683.1 790 2.5e-81 hypothetical protein YQE_04855, partial [Dendroctonus ponderosae]>gi|546685789|gb|ERL95238.1| hypothetical protein D910_12505 [Dendroctonus ponderosae] 887513394 KP641320.1 182 4.68763e-88 Leptinotarsa decemlineata putative twist mRNA, complete cds K09069 TWIST twist http://www.genome.jp/dbget-bin/www_bget?ko:K09069 Q8WVJ9 394 8.6e-37 Twist-related protein 2 OS=Homo sapiens GN=TWIST2 PE=1 SV=1 PF00010//PF04947 Helix-loop-helix DNA-binding domain//Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription GO:0046983 protein dimerization activity -- -- KOG4447 Transcription factor TWIST Cluster-8309.7786 BP_3 38.02 3.91 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7787 BP_3 10.07 0.39 1529 546683367 ERL93189.1 1563 5.7e-171 hypothetical protein D910_10486 [Dendroctonus ponderosae] 733889080 XM_010711334.1 100 1.76144e-42 PREDICTED: Meleagris gallopavo cryptochrome circadian clock 2 (CRY2), mRNA K02295 CRY cryptochrome http://www.genome.jp/dbget-bin/www_bget?ko:K02295 P97784 1276 4.5e-139 Cryptochrome-1 OS=Mus musculus GN=Cry1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0133 Deoxyribodipyrimidine photolyase/cryptochrome Cluster-8309.7788 BP_3 19.72 0.34 3125 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.7790 BP_3 2.00 0.41 524 546687103 ERL95994.1 253 1.6e-19 hypothetical protein D910_00761 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7793 BP_3 3.00 0.34 720 270016030 EFA12478.1 441 3.4e-41 hypothetical protein TcasGA2_TC001502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX7 246 5.7e-20 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.780 BP_3 21.00 0.44 2574 642939780 XP_008193636.1 1085 2.6e-115 PREDICTED: mesoderm induction early response protein 1 isoform X1 [Tribolium castaneum]>gi|642939782|ref|XP_008193643.1| PREDICTED: mesoderm induction early response protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T105 571 4.2e-57 Mesoderm induction early response protein 1 OS=Xenopus laevis GN=mier1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.7813 BP_3 19.18 2.14 723 255653874 ACU25385.1 212 1.2e-14 crustin 4 [Panulirus japonicus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.782 BP_3 57.00 2.26 1507 545889810 XP_005658365.1 513 3.2e-49 PREDICTED: zinc finger protein 33B-like, partial [Sus scrofa] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q06732 497 9.4e-49 Zinc finger protein 33B OS=Homo sapiens GN=ZNF33B PE=1 SV=2 PF13465//PF00096//PF07776//PF16622//PF13912//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//BED zinc finger -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.7820 BP_3 44.82 1.06 2332 270008084 EFA04532.1 1905 1.9e-210 hypothetical protein TcasGA2_TC010411 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2PZL6 332 2.0e-29 Protocadherin Fat 4 OS=Mus musculus GN=Fat4 PE=1 SV=2 PF00028//PF12199 Cadherin domain//Extracellular fibrinogen binding protein C terminal GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0001848//GO:0005509 complement binding//calcium ion binding GO:0005615//GO:0016020 extracellular space//membrane KOG3594 FOG: Cadherin repeats Cluster-8309.7821 BP_3 219.07 4.40 2691 189237315 XP_972608.2 2886 0.0e+00 PREDICTED: protocadherin Fat 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9R0M0 378 1.1e-34 Cadherin EGF LAG seven-pass G-type receptor 2 OS=Mus musculus GN=Celsr2 PE=1 SV=2 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.7822 BP_3 5.40 1.02 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7823 BP_3 1.00 0.38 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7829 BP_3 158.00 12.34 909 642939786 XP_008193657.1 481 9.9e-46 PREDICTED: COMM domain-containing protein 5 [Tribolium castaneum]>gi|642939788|ref|XP_008193664.1| PREDICTED: COMM domain-containing protein 5 [Tribolium castaneum]>gi|270015429|gb|EFA11877.1| hypothetical protein TcasGA2_TC004291 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R395 141 1.1e-07 COMM domain-containing protein 5 OS=Mus musculus GN=Commd5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.783 BP_3 6.00 1.73 459 688550024 XP_005165512.2 306 9.8e-26 PREDICTED: LOW QUALITY PROTEIN: gastrula zinc finger protein XlCGF57.1 [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q68DI1 278 7.1e-24 Zinc finger protein 776 OS=Homo sapiens GN=ZNF776 PE=2 SV=2 PF13465//PF10588//PF13912//PF16622//PF01428//PF00096//PF06397//PF00130//PF07649 Zinc-finger double domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//C2H2-type zinc finger//zinc-finger C2H2-type//AN1-like Zinc finger//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0016491//GO:0005506//GO:0047134//GO:0046872//GO:0008270 oxidoreductase activity//iron ion binding//protein-disulfide reductase activity//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.7834 BP_3 3.22 0.42 664 546681102 ERL91258.1 468 2.3e-44 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7835 BP_3 50.13 3.45 992 546681102 ERL91258.1 468 3.5e-44 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7841 BP_3 326.15 15.96 1277 91085979 XP_971921.1 1520 4.6e-166 PREDICTED: flap endonuclease 1 [Tribolium castaneum]>gi|270009935|gb|EFA06383.1| hypothetical protein TcasGA2_TC009261 [Tribolium castaneum] -- -- -- -- -- K04799 FEN1, RAD2 flap endonuclease-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04799 Q178M1 1380 3.3e-151 Flap endonuclease 1 OS=Aedes aegypti GN=Fen1 PE=3 SV=1 PF00867//PF01367//PF00752 XPG I-region//5'-3' exonuclease, C-terminal SAM fold//XPG N-terminal domain GO:0006281//GO:0043137//GO:0006284//GO:0006308//GO:0090305 DNA repair//DNA replication, removal of RNA primer//base-excision repair//DNA catabolic process//nucleic acid phosphodiester bond hydrolysis GO:0017108//GO:0003824//GO:0003677//GO:0004518//GO:0000287//GO:0008409 5'-flap endonuclease activity//catalytic activity//DNA binding//nuclease activity//magnesium ion binding//5'-3' exonuclease activity GO:0005654//GO:0005739//GO:0005730 nucleoplasm//mitochondrion//nucleolus KOG2519 5'-3' exonuclease Cluster-8309.7842 BP_3 17.85 0.83 1334 91085979 XP_971921.1 1490 1.5e-162 PREDICTED: flap endonuclease 1 [Tribolium castaneum]>gi|270009935|gb|EFA06383.1| hypothetical protein TcasGA2_TC009261 [Tribolium castaneum] -- -- -- -- -- K04799 FEN1, RAD2 flap endonuclease-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04799 Q178M1 1350 1.0e-147 Flap endonuclease 1 OS=Aedes aegypti GN=Fen1 PE=3 SV=1 PF00867//PF00752 XPG I-region//XPG N-terminal domain GO:0043137//GO:0006284//GO:0006281//GO:0090305//GO:0006308 DNA replication, removal of RNA primer//base-excision repair//DNA repair//nucleic acid phosphodiester bond hydrolysis//DNA catabolic process GO:0003677//GO:0017108//GO:0008409//GO:0004518//GO:0000287 DNA binding//5'-flap endonuclease activity//5'-3' exonuclease activity//nuclease activity//magnesium ion binding GO:0005654//GO:0005739//GO:0005730 nucleoplasm//mitochondrion//nucleolus KOG2519 5'-3' exonuclease Cluster-8309.785 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7851 BP_3 1.00 1.22 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7864 BP_3 2.00 0.37 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7867 BP_3 2.85 0.34 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7871 BP_3 4.00 0.45 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7876 BP_3 2.00 0.36 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7877 BP_3 3.00 0.47 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7887 BP_3 7.51 0.38 1234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.789 BP_3 21.33 0.43 2665 642919637 XP_008192001.1 2121 2.0e-235 PREDICTED: eyeless isoform X3 [Tribolium castaneum] 820837347 XM_012493950.1 110 8.56059e-48 PREDICTED: Apis florea paired box protein Pax-6-like (LOC100870332), mRNA K08031 PAX6 paired box protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08031 P26630 1152 1.9e-124 Paired box protein Pax-6 OS=Danio rerio GN=pax6a PE=2 SV=1 PF00292//PF00046//PF05920 'Paired box' domain//Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains Cluster-8309.7897 BP_3 21.00 3.17 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.790 BP_3 21.00 2.76 658 755853642 XP_011295530.1 148 2.9e-07 PREDICTED: nuclear protein 1 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03470 XS zinc finger domain GO:0031047 gene silencing by RNA -- -- -- -- -- -- Cluster-8309.7903 BP_3 2.00 0.67 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7907 BP_3 17.00 0.32 2875 641657023 XP_008180186.1 141 8.3e-06 PREDICTED: zinc finger protein 862-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.791 BP_3 61.96 2.48 1495 270008069 EFA04517.1 314 3.8e-26 hypothetical protein TcasGA2_TC016312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7912 BP_3 153.61 5.11 1740 808122578 XP_012164571.1 251 8.9e-19 PREDICTED: ecdysone-induced protein 78C isoform X1 [Bombus terrestris] -- -- -- -- -- K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7913 BP_3 895.94 13.67 3450 642918349 XP_966635.3 1591 7.3e-174 PREDICTED: ecdysone-induced protein 78C [Tribolium castaneum] -- -- -- -- -- K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 P45447 834 1.8e-87 Ecdysone-induced protein 78C OS=Drosophila melanogaster GN=Eip78C PE=2 SV=4 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.7915 BP_3 10.00 0.44 1383 828218652 XP_012561033.1 376 2.3e-33 PREDICTED: uncharacterized protein LOC105846628 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06203 CCT motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.7916 BP_3 268.00 12.10 1359 91089203 XP_966829.1 1411 2.1e-153 PREDICTED: replication factor C subunit 3 [Tribolium castaneum]>gi|270012468|gb|EFA08916.1| hypothetical protein TcasGA2_TC006622 [Tribolium castaneum] 676459724 XM_009057146.1 56 4.49646e-18 Lottia gigantea hypothetical protein mRNA K10756 RFC3_5 replication factor C subunit 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10756 P40938 1152 9.5e-125 Replication factor C subunit 3 OS=Homo sapiens GN=RFC3 PE=1 SV=2 PF14532//PF06068//PF00004//PF06144 Sigma-54 interaction domain//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//DNA polymerase III, delta subunit GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008134//GO:0003887//GO:0003677//GO:0003678//GO:0005524//GO:0017111 transcription factor binding//DNA-directed DNA polymerase activity//DNA binding//DNA helicase activity//ATP binding//nucleoside-triphosphatase activity GO:0042575//GO:0005667//GO:0005657//GO:0009360 DNA polymerase complex//transcription factor complex//replication fork//DNA polymerase III complex KOG2035 Replication factor C, subunit RFC3 Cluster-8309.792 BP_3 3.00 0.86 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7923 BP_3 28.40 0.77 2065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7928 BP_3 18.76 0.46 2244 478255416 ENN75638.1 1094 2.0e-116 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 833 1.5e-87 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.793 BP_3 32.00 9.31 457 56121719 AAV74196.1 601 6.1e-60 ribosomal protein L26 [Penaeus monodon]>gi|124295601|gb|ABN04203.1| ribosomal protein L26 [Litopenaeus vannamei] 262401435 FJ774900.1 132 8.1368e-61 Scylla paramamosain putative ribosomal protein L26e mRNA, partial cds K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P61255 503 5.8e-50 60S ribosomal protein L26 OS=Mus musculus GN=Rpl26 PE=1 SV=1 PF16906 Ribosomal proteins L26 eukaryotic, L24P archaeal GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit KOG3401 60S ribosomal protein L26 Cluster-8309.7931 BP_3 78.06 3.80 1283 91079654 XP_968593.1 428 2.0e-39 PREDICTED: pupal cuticle protein 20 [Tribolium castaneum]>gi|270004478|gb|EFA00926.1| hypothetical protein TcasGA2_TC003832 [Tribolium castaneum] 755879169 XM_005184939.2 40 3.32314e-09 PREDICTED: Musca domestica pupal cuticle protein Edg-78E-like (LOC101895908), mRNA -- -- -- -- Q8T635 293 3.6e-25 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.7938 BP_3 3.22 0.43 649 642920511 XP_008192380.1 215 4.9e-15 PREDICTED: uncharacterized protein LOC103312733 [Tribolium castaneum] -- -- -- -- -- K10404 KIF26 kinesin family member 26 http://www.genome.jp/dbget-bin/www_bget?ko:K10404 Q29MB2 140 1.0e-07 Kinesin-like protein GA13060 OS=Drosophila pseudoobscura pseudoobscura GN=GA13060 PE=3 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7942 BP_3 47.92 2.43 1241 531446199 AGT57842.1 917 3.7e-96 cytochrome P450 302a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10721 DIB CYP302A1; ecdysteroid 22-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10721 Q9NGX9 580 1.8e-58 Cytochrome P450 302a1, mitochondrial OS=Drosophila melanogaster GN=dib PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.7945 BP_3 2.00 0.41 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7948 BP_3 8.00 1.02 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7956 BP_3 14.72 0.43 1955 270017041 EFA13487.1 238 3.2e-17 hypothetical protein TcasGA2_TC004226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00358 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- -- -- -- -- Cluster-8309.796 BP_3 17.00 0.37 2501 158866359 ABW82155.1 2309 2.9e-257 catalase [Fenneropenaeus chinensis] 260586475 GQ892832.1 2490 0 Scylla paramamosain catalase mRNA, complete cds K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P00432 1950 5.1e-217 Catalase OS=Bos taurus GN=CAT PE=1 SV=3 PF00199 Catalase GO:0006568//GO:0015947//GO:0006979//GO:0006804//GO:0055114 tryptophan metabolic process//methane metabolic process//response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004096//GO:0020037 catalase activity//heme binding -- -- KOG0047 Catalase Cluster-8309.7965 BP_3 10.00 0.71 971 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7971 BP_3 210.23 8.03 1554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01496//PF06009//PF07851 V-type ATPase 116kDa subunit family//Laminin Domain II//TMPIT-like protein GO:0007155//GO:0015992//GO:0015991 cell adhesion//proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0016021//GO:0033179 integral component of membrane//proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.7976 BP_3 20.23 0.63 1831 817190034 XP_012270369.1 166 6.7e-09 PREDICTED: longitudinals lacking protein, isoforms A/B/D/L isoform X23 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q7KQZ4 134 1.4e-06 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF02176//PF00096//PF13465//PF13912//PF02892 TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BED zinc finger -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.7977 BP_3 1.00 0.50 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7978 BP_3 3.00 0.44 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7979 BP_3 6.00 0.49 876 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.798 BP_3 13.00 0.54 1445 827546603 XP_012545709.1 191 6.7e-12 PREDICTED: uncharacterized protein LOC105841614 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7980 BP_3 6.00 0.49 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7981 BP_3 40.00 0.44 4713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365//PF06687//PF04014 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//SUR7/PalI family//Antidote-toxin recognition MazE, bacterial antitoxin GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c GO:0003677 DNA binding GO:0005886//GO:0005743//GO:0005750 plasma membrane//mitochondrial inner membrane//mitochondrial respiratory chain complex III -- -- Cluster-8309.7982 BP_3 30.00 0.60 2685 642915269 XP_972571.2 2221 5.0e-247 PREDICTED: protein scabrous [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21520 947 1.1e-100 Protein scabrous OS=Drosophila melanogaster GN=sca PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7989 BP_3 32.93 1.61 1275 91090027 XP_967605.1 473 1.2e-44 PREDICTED: uroporphyrinogen-III synthase [Tribolium castaneum]>gi|270013699|gb|EFA10147.1| hypothetical protein TcasGA2_TC012334 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10746 234 2.5e-18 Uroporphyrinogen-III synthase OS=Homo sapiens GN=UROS PE=1 SV=1 PF02602 Uroporphyrinogen-III synthase HemD GO:0015994//GO:0033014//GO:0006783 chlorophyll metabolic process//tetrapyrrole biosynthetic process//heme biosynthetic process GO:0004852 uroporphyrinogen-III synthase activity -- -- -- -- Cluster-8309.7996 BP_3 12.00 0.40 1726 807021233 XP_004521159.2 324 3.0e-27 PREDICTED: uncharacterized protein LOC101456261 isoform X3 [Ceratitis capitata] -- -- -- -- -- K06519 SLC3A2, MDU1 solute carrier family 3, member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06519 P10852 224 4.9e-17 4F2 cell-surface antigen heavy chain OS=Mus musculus GN=Slc3a2 PE=1 SV=1 PF02806 Alpha amylase, C-terminal all-beta domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169 catalytic activity//cation binding -- -- KOG0471 Alpha-amylase Cluster-8309.7997 BP_3 4.00 0.43 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.7998 BP_3 360.00 10.90 1884 91095139 XP_973052.1 1169 3.4e-125 PREDICTED: methyltransferase-like protein 16 homolog [Tribolium castaneum]>gi|270015731|gb|EFA12179.1| hypothetical protein TcasGA2_TC002332 [Tribolium castaneum] -- -- -- -- -- K11393 METT10D methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11393 Q6DC64 735 3.0e-76 Methyltransferase-like protein 16 OS=Danio rerio GN=mettl16 PE=2 SV=1 PF09445//PF05971//PF05175//PF08241//PF01596//PF02390 RNA cap guanine-N2 methyltransferase//Protein of unknown function (DUF890)//Methyltransferase small domain//Methyltransferase domain//O-methyltransferase//Putative methyltransferase GO:0006400//GO:0008033//GO:0009451//GO:0008152//GO:0009452//GO:0001510 tRNA modification//tRNA processing//RNA modification//metabolic process//7-methylguanosine RNA capping//RNA methylation GO:0008168//GO:0008176//GO:0008171 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//O-methyltransferase activity -- -- KOG2912 Predicted DNA methylase Cluster-8309.7999 BP_3 58.33 1.02 3047 270001713 EEZ98160.1 3593 0.0e+00 hypothetical protein TcasGA2_TC000586 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q709C8 405 8.9e-38 Vacuolar protein sorting-associated protein 13C OS=Homo sapiens GN=VPS13C PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8 BP_3 8.43 0.58 991 478251268 ENN71740.1 313 3.3e-26 hypothetical protein YQE_11586, partial [Dendroctonus ponderosae] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 P17817 210 1.2e-15 Pyrroline-5-carboxylate reductase OS=Glycine max PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.80 BP_3 2.00 1.84 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8000 BP_3 42.67 0.87 2647 642913428 XP_008201008.1 3081 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q709C8 345 7.0e-31 Vacuolar protein sorting-associated protein 13C OS=Homo sapiens GN=VPS13C PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8004 BP_3 83.77 0.60 7024 270001713 EEZ98160.1 7642 0.0e+00 hypothetical protein TcasGA2_TC000586 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q709C8 617 5.4e-62 Vacuolar protein sorting-associated protein 13C OS=Homo sapiens GN=VPS13C PE=1 SV=1 PF07425 Pardaxin -- -- -- -- GO:0005576 extracellular region KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.8009 BP_3 3.88 0.96 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.801 BP_3 27.00 0.34 4147 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00229 TNF(Tumour Necrosis Factor) family GO:0006955//GO:0007165 immune response//signal transduction GO:0005164 tumor necrosis factor receptor binding GO:0016020 membrane -- -- Cluster-8309.8013 BP_3 32.27 1.51 1321 357631657 EHJ79126.1 932 7.3e-98 hypothetical protein KGM_15588 [Danaus plexippus] 667677333 AE014297.3 84 1.1888e-33 Drosophila melanogaster chromosome 3R K19306 BUD23 18S rRNA (guanine1575-N7)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K19306 O43709 779 1.6e-81 Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens GN=WBSCR22 PE=1 SV=2 PF01555//PF07757//PF08241 DNA methylase//Predicted AdoMet-dependent methyltransferase//Methyltransferase domain GO:0006306//GO:0008152 DNA methylation//metabolic process GO:0008170//GO:0003677//GO:0008168 N-methyltransferase activity//DNA binding//methyltransferase activity -- -- KOG1541 Predicted protein carboxyl methylase Cluster-8309.8015 BP_3 1.00 0.53 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8016 BP_3 11.00 1.39 674 73765582 AAZ85125.1 289 1.3e-23 Down Syndrome adhesion molecule splice variant 3.12.3.1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS29 148 1.2e-08 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.802 BP_3 2.00 0.40 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8022 BP_3 124.44 3.38 2066 642924019 XP_008193971.1 2158 7.8e-240 PREDICTED: von Willebrand factor A domain-containing protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66KD9 1179 1.1e-127 von Willebrand factor A domain-containing protein 9 OS=Xenopus tropicalis GN=vwa9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8023 BP_3 608.75 7.61 4146 642924019 XP_008193971.1 1811 2.7e-199 PREDICTED: von Willebrand factor A domain-containing protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66KD9 1004 4.2e-107 von Willebrand factor A domain-containing protein 9 OS=Xenopus tropicalis GN=vwa9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8024 BP_3 77.81 3.28 1434 642924019 XP_008193971.1 1435 3.7e-156 PREDICTED: von Willebrand factor A domain-containing protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EA76 731 6.6e-76 von Willebrand factor A domain-containing protein 9 OS=Bos taurus GN=VWA9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8025 BP_3 185.43 6.53 1660 642939704 XP_008201400.1 252 6.5e-19 PREDICTED: uncharacterized protein LOC103315176 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8028 BP_3 10.68 1.32 681 -- -- -- -- -- 462276874 APGK01059234.1 95 4.59243e-40 Dendroctonus ponderosae Seq01059244, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8043 BP_3 22.74 0.66 1959 642935798 XP_008198179.1 371 1.2e-32 PREDICTED: CD63 antigen [Tribolium castaneum]>gi|270013280|gb|EFA09728.1| hypothetical protein TcasGA2_TC011861 [Tribolium castaneum] -- -- -- -- -- K06489 CD53, MOX44, TSPAN25 CD53 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06489 Q3ZCD0 149 2.8e-08 CD81 antigen OS=Bos taurus GN=CD81 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8047 BP_3 2.00 0.54 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8048 BP_3 3.00 0.44 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.8051 BP_3 4.00 2.06 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8055 BP_3 277.96 38.58 639 642928441 XP_008193786.1 225 3.4e-16 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8059 BP_3 46.06 0.72 3393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.808 BP_3 26.00 5.98 501 328899728 AEB54646.1 776 3.4e-80 ribosomal protein S11 [Procambarus clarkii] 513011144 XM_004866922.1 145 5.32934e-68 PREDICTED: Heterocephalus glaber ribosomal protein S11 (Rps11), mRNA K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P41115 650 5.7e-67 40S ribosomal protein S11 OS=Xenopus laevis GN=rps11 PE=2 SV=1 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.8085 BP_3 2.00 3.37 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8086 BP_3 16.00 1.78 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8087 BP_3 17.00 1.57 814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8089 BP_3 33.00 0.79 2301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09034 TRADD, N-terminal domain GO:0043123//GO:0007165 positive regulation of I-kappaB kinase/NF-kappaB signaling//signal transduction GO:0005515//GO:0004871 protein binding//signal transducer activity -- -- -- -- Cluster-8309.8094 BP_3 18.00 1.40 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05297//PF03283 Herpesvirus latent membrane protein 1 (LMP1)//Pectinacetylesterase GO:0019087 transformation of host cell by virus GO:0016787 hydrolase activity GO:0016021 integral component of membrane -- -- Cluster-8309.8095 BP_3 100.00 3.27 1767 270009304 EFA05752.1 1561 1.1e-170 paired [Tribolium castaneum] 612025248 XM_007491676.1 86 1.23772e-34 PREDICTED: Monodelphis domestica paired box protein Pax-7-like (LOC100025188), partial mRNA K09381 PAX3_7 paired box protein 3/7 http://www.genome.jp/dbget-bin/www_bget?ko:K09381 P06601 964 7.8e-103 Segmentation protein paired OS=Drosophila melanogaster GN=prd PE=1 SV=1 PF00046//PF00292//PF15281//PF05920 Homeobox domain//'Paired box' domain//Consortin C-terminus//Homeobox KN domain GO:0042998//GO:0006355 positive regulation of Golgi to plasma membrane protein transport//regulation of transcription, DNA-templated GO:0071253//GO:0003677 connexin binding//DNA binding GO:0005802 trans-Golgi network -- -- Cluster-8309.81 BP_3 14.00 1.38 779 91080535 XP_966772.1 452 2.0e-42 PREDICTED: protein mab-21 [Tribolium castaneum]>gi|270005804|gb|EFA02252.1| hypothetical protein TcasGA2_TC007915 [Tribolium castaneum] 641733571 XM_008158995.1 94 1.90192e-39 PREDICTED: Eptesicus fuscus mab-21-like 1 (C. elegans) (MAB21L1), mRNA -- -- -- -- Q5TW90 416 1.2e-39 Protein mab-21 OS=Anopheles gambiae GN=mab-21 PE=3 SV=3 -- -- GO:0045165 cell fate commitment -- -- -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.8119 BP_3 3.00 1.78 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8122 BP_3 11.00 0.76 989 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8124 BP_3 12.00 2.75 502 328899769 AEB54648.1 677 1.0e-68 ribosomal protein S19 [Procambarus clarkii] 262401358 FJ774861.1 290 1.326e-148 Scylla paramamosain ribosomal protein S19e mRNA, partial cds K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 Q94613 500 1.4e-49 40S ribosomal protein S19 OS=Mya arenaria GN=RPS19 PE=2 SV=1 PF01090 Ribosomal protein S19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.8127 BP_3 305.00 10.60 1678 820805556 AKG92769.1 627 2.1e-62 delilah [Leptinotarsa decemlineata] 642919336 XM_008193608.1 38 5.65933e-08 PREDICTED: Tribolium castaneum protein atonal homolog 7-like (LOC103312596), mRNA K09104 K09104 bHLH factor, other http://www.genome.jp/dbget-bin/www_bget?ko:K09104 P41894 260 3.2e-21 Helix-loop-helix protein delilah OS=Drosophila melanogaster GN=tx PE=1 SV=3 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.8131 BP_3 76.98 1.87 2279 642934958 XP_008195953.1 2065 5.2e-229 PREDICTED: TNF receptor-associated factor 4 isoform X4 [Tribolium castaneum] 817199300 XM_012419904.1 272 6.43083e-138 PREDICTED: Orussus abietinus TNF receptor-associated factor 4 (LOC105696990), transcript variant X2, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 1177 2.0e-127 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF15965//PF00096//PF02176//PF03145 TRAF-like zinc-finger//Zinc finger, C2H2 type//TRAF-type zinc finger//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus KOG0297 TNF receptor-associated factor Cluster-8309.8133 BP_3 37.82 0.70 2888 642936275 XP_967688.3 1519 1.4e-165 PREDICTED: protein tincar isoform X1 [Tribolium castaneum]>gi|642936277|ref|XP_008198379.1| PREDICTED: protein tincar isoform X1 [Tribolium castaneum]>gi|642936279|ref|XP_008198380.1| PREDICTED: protein tincar isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B91 453 2.3e-43 Protein tincar OS=Drosophila melanogaster GN=tinc PE=2 SV=1 PF00599//PF05933 Influenza Matrix protein (M2)//Fungal ATP synthase protein 8 (A6L) GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0055036//GO:0033644//GO:0000276 virion membrane//host cell membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.8136 BP_3 119.00 6.42 1185 242018564 XP_002429744.1 259 7.1e-20 conserved hypothetical protein [Pediculus humanus corporis]>gi|212514756|gb|EEB17006.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- K15708 RNF180 E3 ubiquitin-protein ligase RNF180 http://www.genome.jp/dbget-bin/www_bget?ko:K15708 Q5RAK3 172 3.6e-11 E3 ubiquitin-protein ligase RNF180 OS=Pongo abelii GN=RNF180 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8140 BP_3 56.61 0.92 3242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.8141 BP_3 33.28 2.62 904 189236906 XP_001809986.1 1051 7.9e-112 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q80TN5 662 4.2e-68 Palmitoyltransferase ZDHHC17 OS=Mus musculus GN=Zdhhc17 PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.8142 BP_3 8.00 0.61 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8143 BP_3 1.00 0.54 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8150 BP_3 32.34 0.55 3125 531449435 AGT57858.1 318 2.7e-26 cytochrome P450 6ef1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 276 8.3e-23 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.8152 BP_3 53.29 1.80 1717 861645774 KMQ95218.1 153 2.0e-07 cytochrome p450 6a14 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.816 BP_3 23.45 0.74 1821 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8160 BP_3 21.94 1.64 936 478263495 ENN81850.1 315 1.8e-26 hypothetical protein YQE_01788, partial [Dendroctonus ponderosae]>gi|546685498|gb|ERL94996.1| hypothetical protein D910_12268 [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9UKD2 246 7.4e-20 mRNA turnover protein 4 homolog OS=Homo sapiens GN=MRTO4 PE=1 SV=2 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.8164 BP_3 124.26 3.98 1798 270008787 EFA05235.1 1054 7.1e-112 hypothetical protein TcasGA2_TC015381 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 731 8.3e-76 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01118//PF01370//PF01113 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Dihydrodipicolinate reductase, N-terminus GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0009085//GO:0009089//GO:0008210 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//lysine biosynthetic process//lysine biosynthetic process via diaminopimelate//estrogen metabolic process GO:0016620//GO:0016616//GO:0051287//GO:0008839//GO:0003824//GO:0050662//GO:0003854 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//4-hydroxy-tetrahydrodipicolinate reductase//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.8171 BP_3 24.00 1.02 1425 345452835 AEN94569.1 1056 3.3e-112 tetraspanin [Scylla paramamosain] 345452834 HQ260915.1 1239 0 Scylla paramamosain tetraspanin mRNA, complete cds -- -- -- -- Q58DM3 215 4.5e-16 Leukocyte surface antigen CD53 OS=Bos taurus GN=CD53 PE=2 SV=1 PF00335//PF06687 Tetraspanin family//SUR7/PalI family -- -- -- -- GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.8175 BP_3 8.09 1.00 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8176 BP_3 9.00 2.97 437 844843182 XP_012793763.1 226 1.8e-16 60S ribosomal protein L29, partial [Schistosoma haematobium]>gi|685957953|gb|KGB34004.1| 60S ribosomal protein L29, partial [Schistosoma haematobium] 392901673 NM_001268834.1 44 6.43279e-12 Caenorhabditis elegans RPL-29, isoform a (rpl-29), partial mRNA K02905 RP-L29e, RPL29 large subunit ribosomal protein L29e http://www.genome.jp/dbget-bin/www_bget?ko:K02905 Q58DW3 205 2.0e-15 60S ribosomal protein L29 OS=Bos taurus GN=RPL29 PE=2 SV=3 PF01779 Ribosomal L29e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3504 60S ribosomal protein L29 Cluster-8309.8178 BP_3 12.44 0.86 988 91078370 XP_974092.1 375 2.1e-33 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003978|gb|EFA00426.1| hypothetical protein TcasGA2_TC003280 [Tribolium castaneum] -- -- -- -- -- K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 P45952 318 3.5e-28 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acadm PE=1 SV=1 PF02771 Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016627//GO:0050660 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.8180 BP_3 10.59 0.38 1630 642913508 XP_008201043.1 1218 6.2e-131 PREDICTED: corticotropin-releasing factor-binding protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28557 366 1.6e-33 Corticotropin-releasing factor-binding protein OS=Ovis aries GN=CRHBP PE=2 SV=1 PF05428 Corticotropin-releasing factor binding protein (CRF-BP) -- -- GO:0051424 corticotropin-releasing hormone binding -- -- -- -- Cluster-8309.8181 BP_3 20.41 0.73 1642 91077116 XP_970572.1 1233 1.1e-132 PREDICTED: corticotropin-releasing factor-binding protein isoform X1 [Tribolium castaneum]>gi|642913506|ref|XP_008201042.1| PREDICTED: corticotropin-releasing factor-binding protein isoform X1 [Tribolium castaneum]>gi|270002038|gb|EEZ98485.1| hypothetical protein TcasGA2_TC000979 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28557 368 9.3e-34 Corticotropin-releasing factor-binding protein OS=Ovis aries GN=CRHBP PE=2 SV=1 PF05428 Corticotropin-releasing factor binding protein (CRF-BP) -- -- GO:0051424 corticotropin-releasing hormone binding -- -- -- -- Cluster-8309.8186 BP_3 2.05 0.33 594 91091920 XP_967150.1 420 7.6e-39 PREDICTED: 60S ribosomal export protein NMD3 [Tribolium castaneum]>gi|270000793|gb|EEZ97240.1| hypothetical protein TcasGA2_TC011038 [Tribolium castaneum] -- -- -- -- -- K07562 NMD3 nonsense-mediated mRNA decay protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07562 Q6GNS3 251 1.2e-20 60S ribosomal export protein NMD3 OS=Xenopus laevis GN=nmd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2613 NMD protein affecting ribosome stability and mRNA decay Cluster-8309.8187 BP_3 9.00 0.31 1712 91088471 XP_969928.1 1139 9.4e-122 PREDICTED: lactosylceramide 4-alpha-galactosyltransferase [Tribolium castaneum]>gi|642931778|ref|XP_008196724.1| PREDICTED: lactosylceramide 4-alpha-galactosyltransferase [Tribolium castaneum]>gi|270011737|gb|EFA08185.1| hypothetical protein TcasGA2_TC005812 [Tribolium castaneum] -- -- -- -- -- K01988 A4GALT lactosylceramide 4-alpha-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01988 Q67BJ4 359 1.1e-32 Lactosylceramide 4-alpha-galactosyltransferase OS=Mus musculus GN=A4galt PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1928 Alpha-1,4-N-acetylglucosaminyltransferase Cluster-8309.8191 BP_3 1.00 0.40 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8194 BP_3 971.57 64.04 1023 270004639 EFA01087.1 375 2.2e-33 hypothetical protein TcasGA2_TC004010 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V7U0 166 1.5e-10 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.8196 BP_3 26.51 0.35 3934 160333791 NP_001103907.1 2104 2.7e-233 eyeless [Tribolium castaneum]>gi|158187657|gb|ABW23132.1| eyeless [Tribolium castaneum] 820837347 XM_012493950.1 150 7.36845e-70 PREDICTED: Apis florea paired box protein Pax-6-like (LOC100870332), mRNA K08031 PAX6 paired box protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08031 P47238 1169 2.9e-126 Paired box protein Pax-6 OS=Coturnix coturnix japonica GN=PAX6 PE=2 SV=1 -- -- GO:0007275//GO:0006355 multicellular organismal development//regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains Cluster-8309.8198 BP_3 8.51 0.56 1020 91092412 XP_967539.1 564 2.6e-55 PREDICTED: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [Tribolium castaneum]>gi|270004747|gb|EFA01195.1| hypothetical protein TcasGA2_TC010522 [Tribolium castaneum] -- -- -- -- -- K05542 DUS1 tRNA-dihydrouridine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05542 Q6P1R4 295 1.7e-25 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens GN=DUS1L PE=1 SV=1 PF04309//PF01207 Glycerol-3-phosphate responsive antiterminator//Dihydrouridine synthase (Dus) GO:0008033//GO:0055114//GO:0009607//GO:0006355//GO:0008152 tRNA processing//oxidation-reduction process//response to biotic stimulus//regulation of transcription, DNA-templated//metabolic process GO:0017150//GO:0050660 tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.82 BP_3 21.00 1.71 884 478260323 ENN80074.1 1298 1.8e-140 hypothetical protein YQE_03490, partial [Dendroctonus ponderosae]>gi|478260325|gb|ENN80076.1| hypothetical protein YQE_03492, partial [Dendroctonus ponderosae] 815790887 XM_012360585.1 348 1.37604e-180 PREDICTED: Linepithema humile protein mab-21-like (LOC105668301), mRNA -- -- -- -- Q29H56 1169 6.6e-127 Protein mab-21 OS=Drosophila pseudoobscura pseudoobscura GN=mab-21 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.820 BP_3 3.00 0.61 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8200 BP_3 6.00 0.49 886 829839363 XP_012635057.1 1379 7.2e-150 PREDICTED: 40S ribosomal protein S4, X isoform-like [Microcebus murinus] 156071482 NM_001007.4 886 0 Homo sapiens ribosomal protein S4, X-linked (RPS4X), mRNA K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q642H9 1312 1.7e-143 40S ribosomal protein S4, X isoform OS=Danio rerio GN=rps4x PE=2 SV=3 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.821 BP_3 3.00 0.65 514 546677206 ERL88085.1 158 1.6e-08 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8210 BP_3 10.00 3.94 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8211 BP_3 9.00 3.92 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8212 BP_3 42.47 2.72 1044 328697481 XP_003240351.1 420 1.3e-38 PREDICTED: uncharacterized protein LOC100573963 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-8309.8213 BP_3 13.55 0.91 1009 607356691 EZA51190.1 257 1.0e-19 hypothetical protein X777_10260, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8214 BP_3 42.45 2.95 985 759078129 XP_011348854.1 166 3.6e-09 PREDICTED: uncharacterized protein LOC105285975 [Cerapachys biroi]>gi|759078131|ref|XP_011348855.1| PREDICTED: uncharacterized protein LOC105285975 [Cerapachys biroi]>gi|759078133|ref|XP_011348856.1| PREDICTED: uncharacterized protein LOC105285975 [Cerapachys biroi]>gi|759078135|ref|XP_011348857.1| PREDICTED: uncharacterized protein LOC105285975 [Cerapachys biroi]>gi|759078137|ref|XP_011348858.1| PREDICTED: uncharacterized protein LOC105285975 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8215 BP_3 15.54 1.14 947 861599125 KMQ83546.1 246 1.8e-18 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02513 Spin/Ssty Family GO:0007276 gamete generation -- -- -- -- -- -- Cluster-8309.8217 BP_3 1.00 1.76 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.822 BP_3 8.00 0.33 1475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8228 BP_3 47.67 0.42 5781 478251160 ENN71636.1 2246 1.4e-249 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17001//PF01665//PF04843 Type III secretion basal body protein I, YscI, HrpB, PscI//Rotavirus non-structural protein NSP3//Herpesvirus tegument protein, N-terminal conserved region GO:0006508//GO:0009306 proteolysis//protein secretion GO:0003723//GO:0008233 RNA binding//peptidase activity -- -- -- -- Cluster-8309.8231 BP_3 7.64 0.33 1417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8233 BP_3 10.00 0.38 1571 270002408 EEZ98855.1 570 8.2e-56 hypothetical protein TcasGA2_TC004465 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P93748 140 2.4e-07 Putative E3 ubiquitin-protein ligase SINAT1 OS=Arabidopsis thaliana GN=SINAT1 PE=3 SV=1 PF03145//PF02176 Seven in absentia protein family//TRAF-type zinc finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.8240 BP_3 10.77 0.48 1369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8243 BP_3 14.75 0.50 1700 642920283 XP_008192282.1 1027 9.0e-109 PREDICTED: DNA-directed RNA polymerase III subunit RPC3 [Tribolium castaneum]>gi|270006046|gb|EFA02494.1| hypothetical protein TcasGA2_TC008189 [Tribolium castaneum] -- -- -- -- -- K03023 RPC3, POLR3C DNA-directed RNA polymerase III subunit RPC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03023 Q9BUI4 486 2.0e-47 DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens GN=POLR3C PE=1 SV=1 PF05645 RNA polymerase III subunit RPC82 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG2587 RNA polymerase III (C) subunit Cluster-8309.8246 BP_3 2.00 1.24 366 827537336 XP_012546820.1 160 6.6e-09 PREDICTED: protein O-GlcNAcase [Bombyx mori] -- -- -- -- -- K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 133 3.7e-07 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3698 Hyaluronoglucosaminidase Cluster-8309.8252 BP_3 13.52 1.92 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.8253 BP_3 3.00 0.97 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8255 BP_3 1.81 0.51 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8256 BP_3 3.00 0.66 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8258 BP_3 21.70 0.56 2166 642910346 XP_970887.2 1984 1.2e-219 PREDICTED: serine/threonine-protein kinase MAK isoform X2 [Tribolium castaneum] 689931499 LM413849.1 50 1.56656e-14 Enterobius vermicularis genome assembly E_vermicularis_Canary_Islands ,scaffold EVEC_scaffold0000298 K08829 MAK male germ cell-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08829 P20793 1138 6.4e-123 Serine/threonine-protein kinase MAK OS=Rattus norvegicus GN=Mak PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0661 MAPK related serine/threonine protein kinase Cluster-8309.8260 BP_3 15.41 1.21 907 642928019 XP_008200121.1 590 2.3e-58 PREDICTED: GPI ethanolamine phosphate transferase 3 [Tribolium castaneum] -- -- -- -- -- K05288 PIGO phosphatidylinositol glycan, class O http://www.genome.jp/dbget-bin/www_bget?ko:K05288 Q9JJI6 151 7.5e-09 GPI ethanolamine phosphate transferase 3 OS=Mus musculus GN=Pigo PE=1 SV=2 PF03600 Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8264 BP_3 11.12 0.51 1338 642925065 XP_008194155.1 932 7.4e-98 PREDICTED: uncharacterized protein LOC103313212 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80T79 132 1.8e-06 CUB and sushi domain-containing protein 3 OS=Mus musculus GN=Csmd3 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8265 BP_3 3.00 19.00 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8268 BP_3 49.09 3.72 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8277 BP_3 5.00 0.79 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8278 BP_3 1.00 3.59 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.828 BP_3 1.00 0.49 388 733165176 CDP32889.1 589 1.3e-58 MHC class II antigen [Homo sapiens] 158261798 AK290388.1 367 0 Homo sapiens cDNA FLJ78730 complete cds, highly similar to Homo sapiens major histocompatibility complex, class II, DR beta 1, mRNA K06752 MHC2 major histocompatibility complex, class II http://www.genome.jp/dbget-bin/www_bget?ko:K06752 P20039 589 5.2e-60 HLA class II histocompatibility antigen, DRB1-11 beta chain OS=Homo sapiens GN=HLA-DRB1 PE=1 SV=1 PF00129//PF00969 Class I Histocompatibility antigen, domains alpha 1 and 2//Class II histocompatibility antigen, beta domain GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- GO:0016020//GO:0042613 membrane//MHC class II protein complex -- -- Cluster-8309.8287 BP_3 4.00 0.56 638 662215751 XP_008481774.1 187 8.6e-12 PREDICTED: uncharacterized protein LOC103518485 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.829 BP_3 21.00 1.39 1022 659667794 CCO02801.2 837 5.8e-87 MHC class II antigen [Homo sapiens] 158256429 AK291499.1 945 0 Homo sapiens cDNA FLJ77662 complete cds, highly similar to Homo sapiens major histocompatibility complex, class II, DR beta 1, mRNA K06752 MHC2 major histocompatibility complex, class II http://www.genome.jp/dbget-bin/www_bget?ko:K06752 P01912 824 7.7e-87 HLA class II histocompatibility antigen, DRB1-3 chain OS=Homo sapiens GN=HLA-DRB1 PE=1 SV=2 PF00969 Class II histocompatibility antigen, beta domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0016020//GO:0042613 membrane//MHC class II protein complex -- -- Cluster-8309.8304 BP_3 5.00 0.34 993 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8306 BP_3 250.92 5.25 2596 546684608 ERL94225.1 1767 2.1e-194 hypothetical protein D910_11506 [Dendroctonus ponderosae] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q640H3 747 1.7e-77 OTU domain-containing protein 5-B OS=Xenopus laevis GN=otud5-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.8307 BP_3 2.00 0.64 442 190702371 ACE75264.1 490 4.4e-47 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.831 BP_3 12.00 4.85 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8314 BP_3 62.00 27.74 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8317 BP_3 1.00 1.65 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8318 BP_3 3.19 0.46 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8319 BP_3 45.66 0.53 4450 642917872 XP_969181.2 271 1.1e-20 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7B4 153 2.2e-08 Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens GN=SMYD3 PE=1 SV=4 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8320 BP_3 10.00 1.02 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8325 BP_3 7.00 0.45 1037 642922745 XP_008193306.1 441 4.9e-41 PREDICTED: ADP-ribosylation factor-like protein 2-binding protein [Tribolium castaneum] -- -- -- -- -- K16742 ARL2BP, BART ADP-ribosylation factor-like protein 2-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K16742 Q5ZKW5 354 2.5e-32 ADP-ribosylation factor-like protein 2-binding protein OS=Gallus gallus GN=ARL2BP PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8328 BP_3 303.33 6.78 2449 270011827 EFA08275.1 1934 8.7e-214 hypothetical protein TcasGA2_TC005909 [Tribolium castaneum] -- -- -- -- -- K15332 TRMT2A tRNA (uracil-5-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15332 Q8IZ69 1053 5.2e-113 tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 PF01135//PF05175//PF02390//PF08241//PF02384//PF09445//PF05958//PF03602//PF00076//PF05401//PF01209 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Putative methyltransferase//Methyltransferase domain//N-6 DNA Methylase//RNA cap guanine-N2 methyltransferase//tRNA (Uracil-5-)-methyltransferase//Conserved hypothetical protein 95//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Nodulation protein S (NodS)//ubiE/COQ5 methyltransferase family GO:0031167//GO:0006464//GO:0009312//GO:0008033//GO:0006396//GO:0008152//GO:0009452//GO:0001510//GO:0006400//GO:0046500//GO:0006306//GO:0009877//GO:0006479//GO:0009451 rRNA methylation//cellular protein modification process//oligosaccharide biosynthetic process//tRNA processing//RNA processing//metabolic process//7-methylguanosine RNA capping//RNA methylation//tRNA modification//S-adenosylmethionine metabolic process//DNA methylation//nodulation//protein methylation//RNA modification GO:0008168//GO:0008170//GO:0008173//GO:0003677//GO:0008757//GO:0008176//GO:0004719//GO:0003676 methyltransferase activity//N-methyltransferase activity//RNA methyltransferase activity//DNA binding//S-adenosylmethionine-dependent methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//nucleic acid binding -- -- KOG2187 tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes Cluster-8309.8330 BP_3 44.78 2.50 1156 189239979 XP_001808109.1 204 1.7e-13 PREDICTED: uncharacterized protein LOC100142168 [Tribolium castaneum]>gi|270011814|gb|EFA08262.1| hypothetical protein TcasGA2_TC005890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05552 150 1.2e-08 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.8335 BP_3 3.00 1.45 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.834 BP_3 10.00 0.36 1646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8341 BP_3 2.00 0.75 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8343 BP_3 1.00 0.71 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8345 BP_3 2.00 2.91 311 642931615 XP_008196657.1 208 1.5e-14 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Tribolium castaneum] 807033681 XM_004529871.2 56 9.44713e-19 PREDICTED: Ceratitis capitata DNA-directed RNA polymerases I, II, and III subunit RPABC4 (LOC101457024), mRNA K03009 RPB12, POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 http://www.genome.jp/dbget-bin/www_bget?ko:K03009 Q3ZBC0 195 2.0e-14 DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Bos taurus GN=POLR2K PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3507 DNA-directed RNA polymerase, subunit RPB7.0 Cluster-8309.8347 BP_3 36.63 0.47 4054 189234046 XP_968851.2 1200 1.9e-128 PREDICTED: uncharacterized protein LOC657290 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06626 CCNE cyclin E http://www.genome.jp/dbget-bin/www_bget?ko:K06626 P54733 648 7.9e-66 G1/S-specific cyclin-E OS=Drosophila melanogaster GN=CycE PE=1 SV=2 PF02984//PF00554 Cyclin, C-terminal domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0655 G1/S-specific cyclin E Cluster-8309.8348 BP_3 5.04 0.61 690 704187598 XP_010137671.1 154 6.2e-08 PREDICTED: ankyrin-1-like [Buceros rhinoceros silvestris] -- -- -- -- -- K12489 ACAP Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12489 Q96P50 197 2.6e-14 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens GN=ACAP3 PE=1 SV=2 PF13606//PF00023//PF06344 Ankyrin repeat//Ankyrin repeat//Parechovirus Genome-linked protein -- -- GO:0005515 protein binding GO:0019015 viral genome -- -- Cluster-8309.835 BP_3 5.00 0.60 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8351 BP_3 7.68 0.92 695 759068707 XP_011343863.1 238 1.1e-17 PREDICTED: uncharacterized protein LOC105283097 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8357 BP_3 5.82 1.23 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.836 BP_3 5.00 0.69 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8362 BP_3 38.12 3.82 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8367 BP_3 3.00 0.44 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8368 BP_3 6.00 0.37 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8384 BP_3 164.35 5.10 1846 675378821 KFM71723.1 516 1.8e-49 Zinc finger protein 271, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 484 3.7e-47 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF13912//PF01475//PF17123//PF15750//PF00096//PF13465 C2H2-type zinc finger//Ferric uptake regulator family//RING-like zinc finger//Ubiquitin-binding zinc-finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0005515//GO:0003700//GO:0008270//GO:0043130 metal ion binding//protein binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//ubiquitin binding GO:0005667 transcription factor complex -- -- Cluster-8309.8386 BP_3 13.86 0.34 2229 478255416 ENN75638.1 1276 1.6e-137 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 961 2.2e-102 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.8394 BP_3 97.00 2.60 2093 478251184 ENN71660.1 722 2.6e-73 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q3KQG9 542 7.9e-54 Testicular acid phosphatase homolog OS=Xenopus laevis GN=acpt PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.8395 BP_3 4.00 0.31 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8396 BP_3 8.00 0.60 930 270001348 EEZ97795.1 277 4.6e-22 hypothetical protein TcasGA2_TC030737, partial [Tribolium castaneum] -- -- -- -- -- K03353 APC6, CDC16 anaphase-promoting complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03353 Q13042 222 4.5e-17 Cell division cycle protein 16 homolog OS=Homo sapiens GN=CDC16 PE=1 SV=2 PF13371//PF13374//PF13181//PF00515//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit Cluster-8309.8401 BP_3 17.00 0.53 1845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8402 BP_3 16.69 0.89 1191 270007789 EFA04237.1 680 1.1e-68 hypothetical protein TcasGA2_TC014490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4G0P3 442 1.8e-42 Hydrocephalus-inducing protein homolog OS=Homo sapiens GN=HYDIN PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8403 BP_3 283.71 3.61 4083 642934150 XP_008199297.1 2776 3.2e-311 PREDICTED: lethal(3)malignant brain tumor-like protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96JM7 1376 3.0e-150 Lethal(3)malignant brain tumor-like protein 3 OS=Homo sapiens GN=L3MBTL3 PE=1 SV=2 PF11109//PF02198//PF01530//PF07647//PF00536//PF02820 Orexigenic neuropeptide Qrfp/P518//Sterile alpha motif (SAM)/Pointed domain//Zinc finger, C2HC type//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//mbt repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0008270//GO:0043565//GO:0031854//GO:0003700 protein binding//zinc ion binding//sequence-specific DNA binding//orexigenic neuropeptide QRFP receptor binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.8404 BP_3 2.00 0.67 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8406 BP_3 82.94 4.52 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8416 BP_3 162.84 2.79 3109 91079032 XP_974956.1 839 1.0e-86 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270003667|gb|EFA00115.1| hypothetical protein TcasGA2_TC002931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 144 1.7e-07 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.8418 BP_3 11.00 1.13 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8423 BP_3 1.00 1.52 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8425 BP_3 24.00 4.94 526 62860010 NP_001016602.1 691 2.6e-70 40S ribosomal protein S13 [Xenopus (Silurana) tropicalis]>gi|1350933|sp|P49393.2|RS13_XENLA RecName: Full=40S ribosomal protein S13 [Xenopus laevis]>gi|871774|emb|CAA90077.1| orf [Xenopus laevis]>gi|89269947|emb|CAJ81269.1| ribosomal protein S13 [Xenopus (Silurana) tropicalis]>gi|110645571|gb|AAI18691.1| rps13 protein [Xenopus (Silurana) tropicalis] 262401443 FJ774904.1 321 8.13571e-166 Scylla paramamosain ribosomal protein rps13 mRNA, partial cds K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 P49393 691 1.1e-71 40S ribosomal protein S13 OS=Xenopus laevis GN=rps13 PE=3 SV=2 PF00312//PF08069//PF00292 Ribosomal protein S15//Ribosomal S13/S15 N-terminal domain//'Paired box' domain GO:0042254//GO:0006412//GO:0006355 ribosome biogenesis//translation//regulation of transcription, DNA-templated GO:0003735//GO:0003677 structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG0400 40S ribosomal protein S13 Cluster-8309.8426 BP_3 24.43 0.66 2088 642929828 XP_008195992.1 697 2.0e-70 PREDICTED: ephrin-B1 [Tribolium castaneum]>gi|270010986|gb|EFA07434.1| hypothetical protein TcasGA2_TC008794 [Tribolium castaneum] 642929827 XM_008197770.1 182 6.31477e-88 PREDICTED: Tribolium castaneum ephrin-B1 (LOC664511), mRNA K05463 EFNB ephrin-B http://www.genome.jp/dbget-bin/www_bget?ko:K05463 P20827 134 1.6e-06 Ephrin-A1 OS=Homo sapiens GN=EFNA1 PE=1 SV=2 PF00812//PF06449 Ephrin//Mitochondrial domain of unknown function (DUF1082) -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016020//GO:0016021//GO:0005739 membrane//integral component of membrane//mitochondrion KOG3858 Ephrin, ligand for Eph receptor tyrosine kinase Cluster-8309.8427 BP_3 3.87 0.33 863 270016741 EFA13187.1 277 4.2e-22 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08998//PF05699 Bacterial epsilon antitoxin//hAT family C-terminal dimerisation region GO:0031342//GO:0009636//GO:0006955 negative regulation of cell killing//response to toxic substance//immune response GO:0046983//GO:0015643 protein dimerization activity//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.8428 BP_3 5.00 1.44 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8432 BP_3 3.00 0.51 573 -- -- -- -- -- 392303578 JX102611.1 402 0 Scylla paramamosain microsatellite Spm40 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8434 BP_3 45.00 3.77 867 762100997 XP_011432966.1 1012 2.5e-107 PREDICTED: 40S ribosomal protein S2 [Crassostrea gigas] 338224339 HM217811.1 469 0 Scylla paramamosain ribosomal protein S2-like mRNA, partial sequence K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 P49154 992 2.2e-106 40S ribosomal protein S2 OS=Urechis caupo GN=RPS2 PE=2 SV=1 PF03719//PF00333 Ribosomal protein S5, C-terminal domain//Ribosomal protein S5, N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840 ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-8309.8435 BP_3 8.00 0.53 1015 642923126 XP_008193620.1 822 3.2e-85 PREDICTED: tetratricopeptide repeat protein 25 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32NU8 374 1.2e-34 Tetratricopeptide repeat protein 25 OS=Xenopus laevis GN=ttc25 PE=2 SV=1 PF13371//PF00515//PF13181//PF13414//PF13174//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0553 TPR repeat-containing protein Cluster-8309.8436 BP_3 12.00 0.39 1792 326579691 ADZ96217.1 897 1.1e-93 JHE-like carboxylesterase 1 [Pandalopsis japonica] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 657 3.1e-67 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859//PF04434 Prolyl oligopeptidase family//alpha/beta hydrolase fold//SWIM zinc finger GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008270//GO:0016787//GO:0008236 zinc ion binding//hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.8438 BP_3 35.54 0.34 5389 478254383 ENN74635.1 3286 0.0e+00 hypothetical protein YQE_08755, partial [Dendroctonus ponderosae] -- -- -- -- -- K02350 POLZ1, rev3 DNA polymerase zeta http://www.genome.jp/dbget-bin/www_bget?ko:K02350 Q61493 2447 2.6e-274 DNA polymerase zeta catalytic subunit OS=Mus musculus GN=Rev3l PE=1 SV=3 PF02419//PF00136//PF03104 PsbL protein//DNA polymerase family B//DNA polymerase family B, exonuclease domain GO:0015979 photosynthesis GO:0003677//GO:0008408//GO:0000166 DNA binding//3'-5' exonuclease activity//nucleotide binding GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane KOG0968 DNA polymerase zeta, catalytic subunit Cluster-8309.8440 BP_3 107.39 0.70 7705 478254383 ENN74635.1 3286 0.0e+00 hypothetical protein YQE_08755, partial [Dendroctonus ponderosae] -- -- -- -- -- K02350 POLZ1, rev3 DNA polymerase zeta http://www.genome.jp/dbget-bin/www_bget?ko:K02350 Q61493 2447 3.7e-274 DNA polymerase zeta catalytic subunit OS=Mus musculus GN=Rev3l PE=1 SV=3 PF03104//PF02741//PF00136//PF13683 DNA polymerase family B, exonuclease domain//FTR, proximal lobe//DNA polymerase family B//Integrase core domain GO:0006730//GO:0015074 one-carbon metabolic process//DNA integration GO:0000166//GO:0008408//GO:0003677//GO:0016740 nucleotide binding//3'-5' exonuclease activity//DNA binding//transferase activity -- -- KOG0968 DNA polymerase zeta, catalytic subunit Cluster-8309.8443 BP_3 2.00 0.44 513 827537053 XP_012545736.1 171 4.9e-10 PREDICTED: uncharacterized protein LOC101744346 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8444 BP_3 9.21 0.39 1442 642926444 XP_008191961.1 1177 3.1e-126 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009090|gb|EFA05538.1| hypothetical protein TcasGA2_TC015725 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 622 2.9e-63 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF02254//PF01266//PF07992//PF00732//PF05834 TrkA-N domain//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein GO:0016117//GO:0006813//GO:0055114 carotenoid biosynthetic process//potassium ion transport//oxidation-reduction process GO:0050660//GO:0016614//GO:0016705//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- -- -- Cluster-8309.8449 BP_3 5.00 0.84 580 478259752 ENN79593.1 348 1.7e-30 hypothetical protein YQE_03964, partial [Dendroctonus ponderosae] -- -- -- -- -- K18595 EML1_2 echinoderm microtubule-associated protein-like 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18595 Q6P6T4 241 1.8e-19 Echinoderm microtubule-associated protein-like 2 OS=Rattus norvegicus GN=Eml2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8454 BP_3 6.00 0.44 943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8456 BP_3 2.00 4.34 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8457 BP_3 1.00 1.58 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8458 BP_3 10.85 2.46 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8459 BP_3 1.07 0.40 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8461 BP_3 18.00 2.84 597 270009519 EFA05967.1 363 3.1e-32 hypothetical protein TcasGA2_TC008787 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8463 BP_3 16.06 0.81 1252 642929846 XP_008195999.1 1267 9.8e-137 PREDICTED: anoctamin-8 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q6PB70 601 6.8e-61 Anoctamin-8 OS=Mus musculus GN=Ano8 PE=2 SV=3 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.8465 BP_3 308.34 2.97 5296 642929846 XP_008195999.1 1855 2.7e-204 PREDICTED: anoctamin-8 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q6PB70 790 3.5e-82 Anoctamin-8 OS=Mus musculus GN=Ano8 PE=2 SV=3 PF15724//PF16178 TMEM119 family//Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0001503 ossification GO:0046983 protein dimerization activity -- -- KOG2513 Protein required for meiotic chromosome segregation Cluster-8309.8466 BP_3 37.28 0.36 5322 270009519 EFA05967.1 3674 0.0e+00 hypothetical protein TcasGA2_TC008787 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q6PB70 1029 6.8e-110 Anoctamin-8 OS=Mus musculus GN=Ano8 PE=2 SV=3 PF16178//PF15724 Dimerisation domain of Ca+-activated chloride-channel, anoctamin//TMEM119 family GO:0001503 ossification GO:0046983 protein dimerization activity -- -- KOG2514 Uncharacterized conserved protein Cluster-8309.8468 BP_3 5.00 0.78 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.847 BP_3 332.00 9.21 2029 189235403 XP_001811292.1 147 1.2e-06 PREDICTED: histidine-rich glycoprotein [Tribolium castaneum]>gi|270003575|gb|EFA00023.1| hypothetical protein TcasGA2_TC002830 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8473 BP_3 11.87 0.57 1290 642931405 XP_008196566.1 638 8.8e-64 PREDICTED: uncharacterized protein LOC660374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 196 6.4e-14 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8474 BP_3 61.82 5.29 855 642913822 XP_008201174.1 569 5.8e-56 PREDICTED: myosin light chain alkali-like [Tribolium castaneum] -- -- -- -- -- K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 Q24621 364 1.4e-33 Myosin light chain alkali OS=Drosophila pseudoobscura pseudoobscura GN=Mlc1 PE=3 SV=1 PF13499 EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.8475 BP_3 28.57 0.90 1825 270008787 EFA05235.1 1462 3.5e-159 hypothetical protein TcasGA2_TC015381 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 816 1.2e-85 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01370//PF01113//PF01073//PF01118 Male sterility protein//NAD dependent epimerase/dehydratase family//Dihydrodipicolinate reductase, N-terminus//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0055114//GO:0006694//GO:0008209//GO:0008207//GO:0009085//GO:0008210//GO:0009089 oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process//lysine biosynthetic process//estrogen metabolic process//lysine biosynthetic process via diaminopimelate GO:0016620//GO:0080019//GO:0051287//GO:0016616//GO:0008839//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//4-hydroxy-tetrahydrodipicolinate reductase//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.8484 BP_3 7.54 0.50 1021 478251156 ENN71632.1 673 6.1e-68 hypothetical protein YQE_11731, partial [Dendroctonus ponderosae]>gi|546685818|gb|ERL95261.1| hypothetical protein D910_12528 [Dendroctonus ponderosae] 751228675 XM_011169455.1 38 3.4008e-08 PREDICTED: Solenopsis invicta cyclin-dependent kinase 2-like (LOC105201449), mRNA K02087 CDK1, CDC2 cyclin-dependent kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02087 P23572 618 6.0e-63 Cyclin-dependent kinase 1 OS=Drosophila melanogaster GN=cdc2 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.8491 BP_3 2.00 0.34 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8495 BP_3 11.00 0.60 1173 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8496 BP_3 34.00 5.82 573 780671061 XP_011695254.1 162 6.1e-09 PREDICTED: uncharacterized protein LOC105454377 [Wasmannia auropunctata]>gi|780671066|ref|XP_011695256.1| PREDICTED: uncharacterized protein LOC105454377 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01060//PF00341 Transthyretin-like family//PDGF/VEGF domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0016020//GO:0005615 membrane//extracellular space -- -- Cluster-8309.85 BP_3 11.00 1.73 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8507 BP_3 68.00 4.22 1069 91094195 XP_971373.1 955 1.3e-100 PREDICTED: uncharacterized protein C15orf41 homolog [Tribolium castaneum]>gi|270010852|gb|EFA07300.1| hypothetical protein TcasGA2_TC015890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NRW5 509 2.7e-50 Uncharacterized protein C15orf41 homolog OS=Xenopus laevis PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8509 BP_3 10.91 0.63 1133 332373512 AEE61897.1 841 2.2e-87 unknown [Dendroctonus ponderosae]>gi|478261742|gb|ENN80889.1| hypothetical protein YQE_02678, partial [Dendroctonus ponderosae]>gi|546674326|gb|ERL85730.1| hypothetical protein D910_03145 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 Q9VKH6 661 6.8e-68 Lysosomal thioesterase PPT2 homolog OS=Drosophila melanogaster GN=Ppt2 PE=2 SV=1 PF02089 Palmitoyl protein thioesterase -- -- GO:0098599 palmitoyl hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.851 BP_3 2.00 1.02 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8510 BP_3 101.00 6.90 997 270003851 EFA00299.1 406 5.4e-37 hypothetical protein TcasGA2_TC003132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17082//PF08702//PF09177 Spindle Pole Component 29//Fibrinogen alpha/beta chain family//Syntaxin 6, N-terminal GO:0048193//GO:0030474//GO:0051258//GO:0007165//GO:0030168 Golgi vesicle transport//spindle pole body duplication//protein polymerization//signal transduction//platelet activation GO:0005102//GO:0030674//GO:0005200 receptor binding//protein binding, bridging//structural constituent of cytoskeleton GO:0005856//GO:0005577//GO:0016020//GO:0005823 cytoskeleton//fibrinogen complex//membrane//central plaque of spindle pole body -- -- Cluster-8309.8511 BP_3 29.00 0.51 3020 642915527 XP_008190652.1 3214 0.0e+00 PREDICTED: sodium-dependent neutral amino acid transporter B(0)AT3 [Tribolium castaneum]>gi|270003852|gb|EFA00300.1| hypothetical protein TcasGA2_TC003133 [Tribolium castaneum] 665806564 XM_008553307.1 291 2.3435e-148 PREDICTED: Microplitis demolitor sodium-dependent neutral amino acid transporter B(0)AT3 (LOC103573991), mRNA K05048 SLC6A15S solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20 http://www.genome.jp/dbget-bin/www_bget?ko:K05048 O88576 1483 8.8e-163 Sodium-dependent neutral amino acid transporter B(0)AT3 OS=Mus musculus GN=Slc6a18 PE=2 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.8512 BP_3 2.00 0.63 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8513 BP_3 6.00 1.69 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8521 BP_3 2.00 0.72 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8522 BP_3 54.00 0.59 4737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8529 BP_3 2.17 0.45 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14722 Ki-ras-induced actin-interacting protein-IP3R-interacting domain GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.853 BP_3 23.00 1.74 929 857977468 CEO96504.1 524 1.0e-50 hypothetical protein PBRA_005113 [Plasmodiophora brassicae] 697082218 XM_009656135.1 603 0 Verticillium dahliae VdLs.17 superoxide dismutase partial mRNA K04564 SOD2 superoxide dismutase, Fe-Mn family http://www.genome.jp/dbget-bin/www_bget?ko:K04564 Q9Y783 710 1.2e-73 Superoxide dismutase [Mn], mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=sod-2 PE=3 SV=1 PF02777//PF00906//PF00081 Iron/manganese superoxide dismutases, C-terminal domain//Hepatitis core antigen//Iron/manganese superoxide dismutases, alpha-hairpin domain GO:0055114//GO:0006801//GO:0009405 oxidation-reduction process//superoxide metabolic process//pathogenesis GO:0004784//GO:0046872//GO:0005198 superoxide dismutase activity//metal ion binding//structural molecule activity -- -- KOG0876 Manganese superoxide dismutase Cluster-8309.8531 BP_3 33.54 0.90 2096 546675717 ERL86854.1 193 5.7e-12 hypothetical protein D910_04257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845//PF07776 Spore germination protein//Zinc-finger associated domain (zf-AD) GO:0009847 spore germination GO:0008270 zinc ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.8535 BP_3 5.00 0.37 949 156408536 XP_001641912.1 233 5.9e-17 predicted protein [Nematostella vectensis]>gi|156229053|gb|EDO49849.1| predicted protein [Nematostella vectensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.854 BP_3 10.00 1.28 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8541 BP_3 164.00 7.32 1371 189235517 XP_970938.2 1725 8.4e-190 PREDICTED: arf-GAP with dual PH domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75689 954 8.7e-102 Arf-GAP with dual PH domain-containing protein 1 OS=Homo sapiens GN=ADAP1 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0703 Predicted GTPase-activating protein Cluster-8309.8543 BP_3 49.00 2.89 1108 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8544 BP_3 8.26 0.81 784 91092902 XP_971056.1 466 4.7e-44 PREDICTED: N-acetyltransferase 9-like protein [Tribolium castaneum]>gi|270003097|gb|EEZ99544.1| hypothetical protein TcasGA2_TC000126 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7SLC8 247 4.8e-20 N-acetyltransferase 9-like protein OS=Nematostella vectensis GN=nat9 PE=3 SV=1 PF13302//PF02300 Acetyltransferase (GNAT) domain//Fumarate reductase subunit C GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity GO:0016020 membrane KOG4135 Predicted phosphoglucosamine acetyltransferase Cluster-8309.8549 BP_3 42.60 1.74 1475 332373478 AEE61880.1 814 3.9e-84 unknown [Dendroctonus ponderosae]>gi|478263741|gb|ENN82044.1| hypothetical protein YQE_01619, partial [Dendroctonus ponderosae]>gi|546670972|gb|ERL83504.1| hypothetical protein D910_00535 [Dendroctonus ponderosae]>gi|546679616|gb|ERL90053.1| hypothetical protein D910_07409 [Dendroctonus ponderosae] -- -- -- -- -- K00949 thiN, TPK1, THI80 thiamine pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00949 Q9H3S4 487 1.3e-47 Thiamin pyrophosphokinase 1 OS=Homo sapiens GN=TPK1 PE=1 SV=1 PF04263//PF01341//PF04265 Thiamin pyrophosphokinase, catalytic domain//Glycosyl hydrolases family 6//Thiamin pyrophosphokinase, vitamin B1 binding domain GO:0006772//GO:0009229//GO:0005975//GO:0030245 thiamine metabolic process//thiamine diphosphate biosynthetic process//carbohydrate metabolic process//cellulose catabolic process GO:0004553//GO:0005524//GO:0004788//GO:0030975 hydrolase activity, hydrolyzing O-glycosyl compounds//ATP binding//thiamine diphosphokinase activity//thiamine binding -- -- KOG3153 Thiamine pyrophosphokinase Cluster-8309.855 BP_3 6.00 0.67 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8551 BP_3 15.97 0.75 1314 642925065 XP_008194155.1 962 2.4e-101 PREDICTED: uncharacterized protein LOC103313212 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80T79 132 1.7e-06 CUB and sushi domain-containing protein 3 OS=Mus musculus GN=Csmd3 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8552 BP_3 4.00 1.03 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8559 BP_3 11.10 0.78 976 91091562 XP_967054.1 381 4.2e-34 PREDICTED: mRNA turnover protein 4 homolog [Tribolium castaneum]>gi|270000914|gb|EEZ97361.1| hypothetical protein TcasGA2_TC011183 [Tribolium castaneum] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9UKD2 334 4.8e-30 mRNA turnover protein 4 homolog OS=Homo sapiens GN=MRTO4 PE=1 SV=2 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.8560 BP_3 1.20 0.38 446 478263495 ENN81850.1 174 1.9e-10 hypothetical protein YQE_01788, partial [Dendroctonus ponderosae]>gi|546685498|gb|ERL94996.1| hypothetical protein D910_12268 [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9UKD2 154 1.6e-09 mRNA turnover protein 4 homolog OS=Homo sapiens GN=MRTO4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0816 Protein involved in mRNA turnover Cluster-8309.8565 BP_3 9.00 1.90 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8567 BP_3 75.04 1.82 2275 642925115 XP_008194175.1 743 1.0e-75 PREDICTED: uncharacterized protein LOC103313218 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VA00 131 3.9e-06 Protein zwilch OS=Drosophila melanogaster GN=zwilch PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8574 BP_3 16.00 0.97 1087 817057528 XP_012269674.1 438 1.1e-40 PREDICTED: zinc finger MYM-type protein 1-like [Athalia rosae] -- -- -- -- -- -- -- -- -- Q5SVZ6 151 9.0e-09 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 PF05699//PF02529 hAT family C-terminal dimerisation region//Cytochrome B6-F complex subunit 5 -- -- GO:0046983 protein dimerization activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.8575 BP_3 3161.00 118.08 1582 270006981 EFA03429.1 806 3.6e-83 hypothetical protein TcasGA2_TC013418 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8584 BP_3 8.00 0.36 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05238 Kinetochore protein CHL4 like GO:0007059//GO:0034508 chromosome segregation//centromere complex assembly -- -- -- -- -- -- Cluster-8309.8589 BP_3 74.00 3.38 1346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8591 BP_3 59.65 1.41 2338 189240709 XP_001813711.1 1911 3.9e-211 PREDICTED: acyl-CoA synthetase family member 2, mitochondrial [Tribolium castaneum]>gi|270013541|gb|EFA09989.1| hypothetical protein TcasGA2_TC012154 [Tribolium castaneum] -- -- -- -- -- K00666 K00666 fatty-acyl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00666 Q0P4F7 1186 1.9e-128 Acyl-CoA synthetase family member 2, mitochondrial OS=Danio rerio GN=acsf2 PE=2 SV=1 PF08290//PF00501 Hepatitis core protein, putative zinc finger//AMP-binding enzyme GO:0009405//GO:0008152 pathogenesis//metabolic process GO:0005198//GO:0003824 structural molecule activity//catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.8595 BP_3 3.00 0.36 696 827549098 XP_012546687.1 297 1.6e-24 PREDICTED: uncharacterized protein LOC105841770 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8596 BP_3 25.00 0.41 3214 641654097 XP_008179069.1 451 1.1e-41 PREDICTED: uncharacterized protein LOC103308105 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12162 STAT1 TAZ2 binding domain -- -- GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.8597 BP_3 93.00 4.40 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00447//PF00060 HSF-type DNA-binding//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006355//GO:0006811 signal transduction//synaptic transmission//regulation of transcription, DNA-templated//ion transport GO:0004970//GO:0043565//GO:0003700 ionotropic glutamate receptor activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0016020 nucleus//transcription factor complex//membrane -- -- Cluster-8309.86 BP_3 6.00 1.53 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8601 BP_3 100.45 3.19 1809 270005448 EFA01896.1 1215 1.5e-130 hypothetical protein TcasGA2_TC007506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q42524 865 2.4e-91 4-coumarate--CoA ligase 1 OS=Arabidopsis thaliana GN=4CL1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.8603 BP_3 16.79 0.67 1493 755690989 XP_011281661.1 468 5.2e-44 PREDICTED: uncharacterized protein LOC101086622 [Felis catus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9Y6Q3 473 5.7e-46 Zinc finger protein 37 homolog OS=Homo sapiens GN=ZFP37 PE=2 SV=3 PF00320//PF16622//PF13912//PF00130//PF00096//PF13465 GATA zinc finger//zinc-finger C2H2-type//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0043565//GO:0008270//GO:0003700//GO:0046872 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0005667 transcription factor complex -- -- Cluster-8309.8606 BP_3 2.00 4.04 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8614 BP_3 1.00 0.72 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8617 BP_3 19.03 1.06 1159 861611643 KMQ85334.1 175 3.8e-10 hypothetical protein RF55_16186, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8620 BP_3 61.00 3.87 1052 383855073 XP_003703043.1 811 6.2e-84 PREDICTED: 60S ribosomal protein L7 [Megachile rotundata] 238477340 FJ478023.1 106 5.54651e-46 Rimicaris exoculata ribosomal protein L7 mRNA, partial cds K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 P32100 739 5.7e-77 60S ribosomal protein L7 OS=Drosophila melanogaster GN=RpL7 PE=1 SV=2 PF00336 DNA polymerase (viral) C-terminal domain GO:0051252 regulation of RNA metabolic process GO:0004523 RNA-DNA hybrid ribonuclease activity -- -- KOG3184 60S ribosomal protein L7 Cluster-8309.863 BP_3 3.00 1.82 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8632 BP_3 3.00 0.57 545 642939955 XP_008200728.1 157 2.2e-08 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622 zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.8634 BP_3 6.00 0.45 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8635 BP_3 28.00 0.57 2641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8642 BP_3 16.29 1.42 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8643 BP_3 13.71 0.81 1111 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8644 BP_3 15.33 0.46 1906 780712889 XP_011704975.1 188 2.0e-11 PREDICTED: uncharacterized protein LOC105460239 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977//PF05485 Septum formation initiator//THAP domain GO:0007049 cell cycle GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.8647 BP_3 31.00 1.84 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8648 BP_3 26.00 1.48 1136 270016431 EFA12877.1 360 1.3e-31 hypothetical protein TcasGA2_TC011555 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF01581//PF00096 C2H2-type zinc finger//FMRFamide related peptide family//Zinc finger, C2H2 type GO:0007218 neuropeptide signaling pathway GO:0046872 metal ion binding -- -- -- -- Cluster-8309.865 BP_3 2.95 0.61 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8650 BP_3 4.32 0.32 935 91083701 XP_969551.1 273 1.3e-21 PREDICTED: PITH domain-containing protein CG6153 [Tribolium castaneum]>gi|270006812|gb|EFA03260.1| hypothetical protein TcasGA2_TC013194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VK68 234 1.8e-18 PITH domain-containing protein CG6153 OS=Drosophila melanogaster GN=CG6153 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1730 Thioredoxin-like protein Cluster-8309.8658 BP_3 261.48 10.29 1517 332372618 AEE61451.1 898 7.3e-94 unknown [Dendroctonus ponderosae]>gi|478254395|gb|ENN74647.1| hypothetical protein YQE_08765, partial [Dendroctonus ponderosae]>gi|546682357|gb|ERL92305.1| hypothetical protein D910_09622 [Dendroctonus ponderosae] -- -- -- -- -- K15433 CGI99, CLE7, RLLM1 RLL motif containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15433 Q9Y224 446 7.8e-43 UPF0568 protein C14orf166 OS=Homo sapiens GN=C14orf166 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4380 Carnitine deficiency associated protein Cluster-8309.8659 BP_3 10.20 0.39 1564 332372618 AEE61451.1 603 1.2e-59 unknown [Dendroctonus ponderosae]>gi|478254395|gb|ENN74647.1| hypothetical protein YQE_08765, partial [Dendroctonus ponderosae]>gi|546682357|gb|ERL92305.1| hypothetical protein D910_09622 [Dendroctonus ponderosae] -- -- -- -- -- K15433 CGI99, CLE7, RLLM1 RLL motif containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15433 Q9Y224 264 1.0e-21 UPF0568 protein C14orf166 OS=Homo sapiens GN=C14orf166 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4380 Carnitine deficiency associated protein Cluster-8309.866 BP_3 9.05 2.86 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8661 BP_3 1379.00 29.95 2511 642914220 XP_008201595.1 312 1.1e-25 PREDICTED: myb-like protein K [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.8665 BP_3 16.00 1.22 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8666 BP_3 9.00 1.13 674 642929063 XP_008195676.1 227 2.1e-16 PREDICTED: flocculation protein FLO11 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.867 BP_3 67.95 2.72 1495 91091646 XP_970895.1 265 1.8e-20 PREDICTED: adult-specific cuticular protein ACP-20 [Tribolium castaneum]>gi|270000889|gb|EEZ97336.1| hypothetical protein TcasGA2_TC011148 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11733 191 2.8e-13 Cuticle protein 7 OS=Locusta migratoria PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8675 BP_3 35.45 0.86 2284 546685251 ERL94778.1 1184 7.6e-127 hypothetical protein D910_12052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2Q2 261 3.3e-21 FERM domain-containing protein 4A OS=Homo sapiens GN=FRMD4A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8682 BP_3 4.00 0.54 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8688 BP_3 38.29 1.76 1338 642923159 XP_008193634.1 919 2.4e-96 PREDICTED: uncharacterized protein LOC103313083 isoform X2 [Tribolium castaneum]>gi|270007587|gb|EFA04035.1| hypothetical protein TcasGA2_TC014264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08133 Anticodon nuclease activator family GO:0050792 regulation of viral process GO:0004518 nuclease activity -- -- -- -- Cluster-8309.8689 BP_3 71.00 1.66 2349 642922414 XP_008193147.1 914 1.6e-95 PREDICTED: transcription factor Sox-3 [Tribolium castaneum]>gi|270008206|gb|EFA04654.1| SoxNeuro [Tribolium castaneum] 751217116 XM_011163231.1 110 7.53202e-48 PREDICTED: Solenopsis invicta transcription factor Sox-3 (LOC105197035), transcript variant X3, mRNA K09267 SOX1S transcription factor SOX1/3/14/21 (SOX group B) http://www.genome.jp/dbget-bin/www_bget?ko:K09267 Q68FA4 438 1.0e-41 Transcription factor Sox-3 OS=Xenopus tropicalis GN=sox3 PE=2 SV=1 PF12336 SOX transcription factor GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.8690 BP_3 175.31 5.39 1858 642916330 XP_008190976.1 694 4.0e-70 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|270004190|gb|EFA00638.1| hypothetical protein TcasGA2_TC003514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25386 149 2.6e-08 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF02183//PF10473 Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006355 regulation of transcription, DNA-templated GO:0045502//GO:0008134//GO:0003700//GO:0043565//GO:0042803 dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.8692 BP_3 7.78 0.74 795 270011788 EFA08236.1 446 9.9e-42 hypothetical protein TcasGA2_TC005864 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04825 N terminus of Rad21 / Rec8 like protein -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8693 BP_3 5.00 1.80 425 700894663 AIU99750.1 272 7.9e-22 mitochondrial cytochrome c oxidase subunit VIc [Litopenaeus vannamei] -- -- -- -- -- K02268 COX6C cytochrome c oxidase subunit 6c http://www.genome.jp/dbget-bin/www_bget?ko:K02268 P80977 198 1.2e-14 Cytochrome c oxidase subunit 6C-1 OS=Thunnus obesus PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8696 BP_3 20.78 0.37 2990 657592270 XP_008300654.1 354 1.7e-30 PREDICTED: zinc finger protein 345-like isoform X1 [Stegastes partitus] -- -- -- -- -- -- -- -- -- Q8TC21 320 6.3e-28 Zinc finger protein 596 OS=Homo sapiens GN=ZNF596 PE=2 SV=2 PF00096//PF13465//PF02150//PF10426//PF01363//PF13912//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit//Recombination-activating protein 1 zinc-finger domain//FYVE zinc finger//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0016788//GO:0003677//GO:0016881//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//hydrolase activity, acting on ester bonds//DNA binding//acid-amino acid ligase activity//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.8698 BP_3 27.41 0.41 3552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07348//PF00096//PF10426//PF06467//PF07776//PF13465//PF13912//PF05191 Syd protein (SUKH-2)//Zinc finger, C2H2 type//Recombination-activating protein 1 zinc-finger domain//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//C2H2-type zinc finger//Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0016881//GO:0008270//GO:0004017//GO:0046872//GO:0016788 acid-amino acid ligase activity//zinc ion binding//adenylate kinase activity//metal ion binding//hydrolase activity, acting on ester bonds GO:0009898//GO:0005634 cytoplasmic side of plasma membrane//nucleus -- -- Cluster-8309.87 BP_3 173.39 5.03 1953 642920408 XP_008192335.1 389 9.9e-35 PREDICTED: putative lysozyme-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.870 BP_3 71.00 1.30 2932 91090904 XP_973747.1 1018 1.7e-107 PREDICTED: dual specificity protein kinase TTK [Tribolium castaneum]>gi|270014248|gb|EFA10696.1| altered disjunction [Tribolium castaneum] -- -- -- -- -- K08866 TTK, MPS1 serine/threonine-protein kinase TTK/MPS1 http://www.genome.jp/dbget-bin/www_bget?ko:K08866 Q8AYG3 530 2.7e-52 Dual specificity protein kinase Ttk OS=Danio rerio GN=ttk PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0016772//GO:0000166//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//transferase activity, transferring phosphorus-containing groups//nucleotide binding//protein kinase activity GO:0016020 membrane KOG0596 Dual specificity; serine/threonine and tyrosine kinase Cluster-8309.8704 BP_3 3.01 0.32 742 478260499 ENN80210.1 249 6.5e-19 hypothetical protein YQE_03362, partial [Dendroctonus ponderosae]>gi|546684187|gb|ERL93892.1| hypothetical protein D910_11178 [Dendroctonus ponderosae] -- -- -- -- -- K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 P51159 223 2.7e-17 Ras-related protein Rab-27A OS=Homo sapiens GN=RAB27A PE=1 SV=3 PF08477//PF00071 Ras of Complex, Roc, domain of DAPkinase//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0081 GTPase Rab27, small G protein superfamily Cluster-8309.8705 BP_3 165.00 5.18 1828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8706 BP_3 17.10 0.85 1256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8708 BP_3 25.31 0.93 1601 332377013 AEE63646.1 936 3.0e-98 unknown [Dendroctonus ponderosae]>gi|478253342|gb|ENN73703.1| hypothetical protein YQE_09700, partial [Dendroctonus ponderosae]>gi|546673935|gb|ERL85446.1| hypothetical protein D910_02865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P36963 200 2.8e-14 Proteolipid protein DM alpha OS=Squalus acanthias PE=2 SV=1 PF01275 Myelin proteolipid protein (PLP or lipophilin) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8709 BP_3 55.71 1.24 2454 642936506 XP_008198464.1 2042 2.6e-226 PREDICTED: LOW QUALITY PROTEIN: alpha-2C adrenergic receptor [Tribolium castaneum] -- -- -- -- -- K04140 ADRA2C adrenergic receptor alpha-2C http://www.genome.jp/dbget-bin/www_bget?ko:K04140 Q90WY6 475 5.5e-46 Alpha-2C adrenergic receptor OS=Danio rerio GN=adra2c PE=3 SV=1 PF00001//PF01080 7 transmembrane receptor (rhodopsin family)//Presenilin GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0004190 G-protein coupled receptor activity//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.871 BP_3 21.00 0.66 1820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8710 BP_3 32.70 0.81 2238 651208174 AIC75371.1 1089 7.7e-116 octopamine receptor short variant [Chilo suppressalis] -- -- -- -- -- K04138 ADRA2A adrenergic receptor alpha-2A http://www.genome.jp/dbget-bin/www_bget?ko:K04138 Q90WY6 475 5.0e-46 Alpha-2C adrenergic receptor OS=Danio rerio GN=adra2c PE=3 SV=1 PF00001//PF01080 7 transmembrane receptor (rhodopsin family)//Presenilin GO:0007186 G-protein coupled receptor signaling pathway GO:0004190//GO:0004930 aspartic-type endopeptidase activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.8714 BP_3 12.19 0.33 2081 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02285 Cytochrome oxidase c subunit VIII GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.8720 BP_3 10.00 0.54 1185 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8722 BP_3 252.27 1.80 7036 642939568 XP_001808071.2 861 6.6e-89 PREDICTED: uncharacterized protein LOC100141755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03137 Organic Anion Transporter Polypeptide (OATP) family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.8724 BP_3 7.00 1.16 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8725 BP_3 36.07 0.49 3856 270000924 EEZ97371.1 386 4.4e-34 hypothetical protein TcasGA2_TC011194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF15966//PF13516//PF12937 F-box domain//F-box//Leucine Rich repeat//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8726 BP_3 3.15 1.38 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8732 BP_3 18.70 0.53 1997 91091050 XP_975260.1 1776 1.5e-195 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270014061|gb|EFA10509.1| hypothetical protein TcasGA2_TC012760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17NV8 583 1.3e-58 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.8733 BP_3 1.00 1.72 303 849976741 AKN46052.1 221 4.6e-16 trypsin-like serine proteinase [Eriocheir sinensis] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P07146 192 4.4e-14 Anionic trypsin-2 OS=Mus musculus GN=Prss2 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.8734 BP_3 3.00 0.43 626 62752065 AAX98287.1 523 9.2e-51 hepatopancreas trypsin, partial [Astacus leptodactylus] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P00765 503 7.9e-50 Trypsin-1 OS=Astacus astacus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.8735 BP_3 4.00 0.59 616 307188246 EFN73065.1 252 2.4e-19 hypothetical protein EAG_00196, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8736 BP_3 9.00 0.67 944 429535130 CCE73651.2 1372 4.9e-149 chymotrypsin-like proteinase [Scylla paramamosain] 429535129 HE614125.2 908 0 Scylla paramamosain mRNA for chymotrypsin-like proteinase (spchy gene) K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P36178 1094 3.5e-118 Chymotrypsin BII OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.8742 BP_3 5.00 1.94 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8756 BP_3 367.00 3.01 6169 642933339 XP_008197373.1 4467 0.0e+00 PREDICTED: roundabout homolog 2 [Tribolium castaneum] -- -- -- -- -- K06753 ROBO1 roundabout, axon guidance receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06753 O89026 1384 5.4e-151 Roundabout homolog 1 OS=Mus musculus GN=Robo1 PE=1 SV=1 PF15957//PF13895//PF00041 Commissureless//Immunoglobulin domain//Fibronectin type III domain GO:0007411 axon guidance GO:0005515 protein binding -- -- KOG4222 Axon guidance receptor Dscam Cluster-8309.8758 BP_3 17.00 0.49 1956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8763 BP_3 78.00 2.46 1817 642916582 XP_008191780.1 1039 3.9e-110 PREDICTED: transcription initiation protein SPT3 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75486 280 1.7e-23 Transcription initiation protein SPT3 homolog OS=Homo sapiens GN=SUPT3H PE=1 SV=2 PF01592//PF02269 NifU-like N terminal domain//Transcription initiation factor IID, 18kD subunit GO:0016226//GO:0006366 iron-sulfur cluster assembly//transcription from RNA polymerase II promoter GO:0051536//GO:0005506 iron-sulfur cluster binding//iron ion binding -- -- -- -- Cluster-8309.8769 BP_3 5.00 7.59 309 347970432 XP_313496.5 173 1.7e-10 AGAP003703-PA [Anopheles gambiae str. PEST]>gi|333468931|gb|EAA08939.5| AGAP003703-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- Q9VC45 150 3.3e-09 Protein abnormal spindle OS=Drosophila melanogaster GN=asp PE=1 SV=3 PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.877 BP_3 1.00 15.53 232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8771 BP_3 59.50 2.85 1298 91080169 XP_970176.1 714 1.4e-72 PREDICTED: protein abnormal spindle [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VC45 349 1.2e-31 Protein abnormal spindle OS=Drosophila melanogaster GN=asp PE=1 SV=3 PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8774 BP_3 66.74 1.10 3220 189235651 XP_969031.2 2273 5.6e-253 PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917505|ref|XP_008191230.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917507|ref|XP_008191231.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917509|ref|XP_008191232.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum] 389611492 AK402738.1 219 2.64617e-108 Papilio xuthus mRNA for dusky, partial cds, sequence id: Px-0224, expressed in epidermis -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8779 BP_3 174.00 4.10 2338 270003200 EEZ99647.1 228 5.5e-16 hypothetical protein TcasGA2_TC002404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.878 BP_3 17.00 2.50 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8786 BP_3 10.00 4.64 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.879 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8790 BP_3 1.00 1.14 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8793 BP_3 6.00 0.49 888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8797 BP_3 7.00 0.33 1327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8799 BP_3 5.00 0.33 1014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8800 BP_3 7.25 0.47 1037 332373854 AEE62068.1 526 6.8e-51 unknown [Dendroctonus ponderosae] 642918806 XM_008193372.1 79 5.582e-31 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase PP1-alpha-like (LOC103312533), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q9UW86 449 2.4e-43 Serine/threonine-protein phosphatase PP1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=pph-3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.8805 BP_3 13.19 0.32 2285 642933000 XP_008197222.1 3111 0.0e+00 PREDICTED: dynein heavy chain 3, axonemal [Tribolium castaneum] 462278248 APGK01058707.1 63 9.81491e-22 Dendroctonus ponderosae Seq01058717, whole genome shotgun sequence K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8BW94 2404 1.1e-269 Dynein heavy chain 3, axonemal OS=Mus musculus GN=Dnah3 PE=2 SV=2 PF03028//PF07809 Dynein heavy chain and region D6 of dynein motor//RTP801 C-terminal region GO:0007017//GO:0007018//GO:0009968 microtubule-based process//microtubule-based movement//negative regulation of signal transduction GO:0003777 microtubule motor activity GO:0005874//GO:0005737//GO:0030286 microtubule//cytoplasm//dynein complex -- -- Cluster-8309.8807 BP_3 4.07 0.35 855 642915071 XP_008190398.1 345 5.5e-30 PREDICTED: protein groucho isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P16371 140 1.3e-07 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8811 BP_3 1.00 0.64 364 675390536 KFM83433.1 138 2.3e-06 hypothetical protein X975_20011, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF02892//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//BED zinc finger//C2H2-type zinc finger -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.8818 BP_3 21.00 0.71 1723 402715413 1PDZ 2131 8.8e-237 Chain A, X-Ray Structure And Catalytic Mechanism Of Lobster Enolase>gi|408489435|pdb|1PDY|A Chain A, X-Ray Structure And Catalytic Mechanism Of Lobster Enolase 41394398 AY522936.1 976 0 Callinectes sapidus 2-phospho-D-glycerate hydrolase mRNA, partial cds K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 P56252 2131 3.6e-238 Enolase OS=Homarus gammarus PE=1 SV=1 PF00113//PF03952 Enolase, C-terminal TIM barrel domain//Enolase, N-terminal domain GO:0006096//GO:0009094//GO:0006094//GO:0006571//GO:0000162 glycolytic process//L-phenylalanine biosynthetic process//gluconeogenesis//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0004634//GO:0000287 phosphopyruvate hydratase activity//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-8309.8819 BP_3 5.28 0.42 899 189237193 XP_001808466.1 395 9.2e-36 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Tribolium castaneum] -- -- -- -- -- K09008 NDUFAF3 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09008 Q6DFN1 197 3.4e-14 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Xenopus tropicalis GN=ndufaf3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3363 Uncharacterized conserved nuclear protein Cluster-8309.882 BP_3 3.00 0.41 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8820 BP_3 69.43 6.60 799 189237193 XP_001808466.1 604 4.8e-60 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Tribolium castaneum] -- -- -- -- -- K09008 NDUFAF3 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09008 A1L1F1 260 1.5e-21 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Danio rerio GN=ndufaf3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3363 Uncharacterized conserved nuclear protein Cluster-8309.8821 BP_3 26.81 0.80 1899 478261514 ENN80859.1 442 6.9e-41 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 331 2.1e-29 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.8825 BP_3 72.50 4.48 1071 642914660 XP_974035.2 503 3.3e-48 PREDICTED: transmembrane protein 230 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CIB6 284 3.4e-24 Transmembrane protein 230 OS=Mus musculus GN=Tmem230 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4753 Predicted membrane protein Cluster-8309.8827 BP_3 10.00 0.54 1183 282403497 NP_001164145.1 773 1.8e-79 caspase-like protein [Tribolium castaneum]>gi|642916782|ref|XP_008199500.1| PREDICTED: caspase-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08738 250 3.2e-20 Caspase-6 OS=Mus musculus GN=Casp6 PE=2 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG3573 Caspase, apoptotic cysteine protease Cluster-8309.8830 BP_3 36.12 0.94 2151 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8831 BP_3 28.00 7.35 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8834 BP_3 1.00 0.34 432 290909033 ADD70031.1 168 9.2e-10 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.8841 BP_3 63.48 3.08 1284 642936495 XP_008198460.1 253 3.8e-19 PREDICTED: protein tantalus isoform X2 [Tribolium castaneum]>gi|642936497|ref|XP_008198461.1| PREDICTED: protein tantalus isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8843 BP_3 6.77 0.47 986 642917366 XP_008199274.1 1229 2.0e-132 PREDICTED: transmembrane channel-like protein 3 [Tribolium castaneum] 242003851 XM_002422840.1 86 6.80531e-35 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- Q8R4P4 603 3.2e-61 Transmembrane channel-like protein 2 OS=Mus musculus GN=Tmc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8844 BP_3 21.10 0.33 3333 642917366 XP_008199274.1 1328 2.2e-143 PREDICTED: transmembrane channel-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5YCC7 612 9.7e-62 Transmembrane channel-like protein 3 OS=Gallus gallus GN=Tmc3 PE=2 SV=1 PF07810 TMC domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8845 BP_3 20.90 0.35 3176 642917366 XP_008199274.1 1328 2.1e-143 PREDICTED: transmembrane channel-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5YCC7 612 9.2e-62 Transmembrane channel-like protein 3 OS=Gallus gallus GN=Tmc3 PE=2 SV=1 PF07810 TMC domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8846 BP_3 199.00 16.36 878 91076320 XP_970028.1 404 8.1e-37 PREDICTED: endocuticle structural glycoprotein SgAbd-2 [Tribolium castaneum]>gi|270002481|gb|EEZ98928.1| hypothetical protein TcasGA2_TC004548 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 226 1.5e-17 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.8847 BP_3 7.19 0.33 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8849 BP_3 92.89 0.56 8311 642934007 XP_008197600.1 1043 6.2e-110 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] 584600633 EU595402.2 44 1.3158e-10 Drosophila virilis kl-2 1-beta dynein heavy chain mRNA, partial cds K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P0C6F1 763 7.4e-79 Dynein heavy chain 2, axonemal OS=Mus musculus GN=Dnah2 PE=2 SV=1 PF02993//PF00008//PF03028//PF01467 Minor capsid protein VI//EGF-like domain//Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like GO:0007018//GO:0009058//GO:0007017 microtubule-based movement//biosynthetic process//microtubule-based process GO:0003777//GO:0005515//GO:0003824 microtubule motor activity//protein binding//catalytic activity GO:0005874//GO:0030286//GO:0019028 microtubule//dynein complex//viral capsid KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.8851 BP_3 82.34 2.17 2124 642934007 XP_008197600.1 1055 6.4e-112 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K06210 NMNAT nicotinamide mononucleotide adenylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06210 Q9EPA7 633 2.3e-64 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Mus musculus GN=Nmnat1 PE=1 SV=2 PF03028//PF01467//PF00008 Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like//EGF-like domain GO:0007018//GO:0009058//GO:0007017 microtubule-based movement//biosynthetic process//microtubule-based process GO:0005515//GO:0003777//GO:0003824 protein binding//microtubule motor activity//catalytic activity GO:0005874//GO:0030286 microtubule//dynein complex KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.8858 BP_3 10.00 0.72 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8862 BP_3 1.00 1.84 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8863 BP_3 2.05 0.38 553 91082339 XP_966549.1 342 7.9e-30 PREDICTED: DNA-directed RNA polymerase III subunit RPC2 [Tribolium castaneum]>gi|270007487|gb|EFA03935.1| hypothetical protein TcasGA2_TC014075 [Tribolium castaneum] 330793439 XM_003284744.1 35 8.31997e-07 Dictyostelium purpureum RNA polymerase III, second largest subunit, mRNA K03021 RPC2, POLR3B DNA-directed RNA polymerase III subunit RPC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03021 P25167 317 2.6e-28 DNA-directed RNA polymerase III subunit RPC2 OS=Drosophila melanogaster GN=RpIII128 PE=2 SV=2 -- -- GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0032549 DNA binding//DNA-directed RNA polymerase activity//ribonucleoside binding GO:0005730 nucleolus KOG0215 RNA polymerase III, second largest subunit Cluster-8309.8869 BP_3 9.00 0.37 1473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15499 Ubiquitin-specific peptidase-like, SUMO isopeptidase -- -- GO:0032183//GO:0070140 SUMO binding//SUMO-specific isopeptidase activity -- -- -- -- Cluster-8309.887 BP_3 13.00 0.39 1885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8871 BP_3 8.11 1.23 610 478253482 ENN73809.1 449 3.4e-42 hypothetical protein YQE_09587, partial [Dendroctonus ponderosae]>gi|546679134|gb|ERL89639.1| hypothetical protein D910_07004 [Dendroctonus ponderosae] 645007869 XM_001600661.3 78 1.15295e-30 PREDICTED: Nasonia vitripennis adrenodoxin-like protein, mitochondrial (LOC100118135), mRNA -- -- -- -- P37193 398 1.2e-37 Adrenodoxin-like protein, mitochondrial OS=Drosophila melanogaster GN=Fdxh PE=2 SV=3 PF09749 Uncharacterised conserved protein GO:0034477 U6 snRNA 3'-end processing GO:0004518 nuclease activity -- -- KOG3309 Ferredoxin Cluster-8309.8872 BP_3 1.00 0.93 336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8883 BP_3 2.39 0.96 411 646465981 KDQ65252.1 225 2.2e-16 hypothetical protein L798_00087, partial [Zootermopsis nevadensis]>gi|646718091|gb|KDR20693.1| hypothetical protein L798_04842, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8884 BP_3 14.00 0.83 1100 642923819 XP_008193893.1 795 4.7e-82 PREDICTED: leukocyte surface antigen CD53-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8885 BP_3 6.61 0.56 857 270007766 EFA04214.1 378 8.2e-34 hypothetical protein TcasGA2_TC014463 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8887 BP_3 9.00 0.52 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8889 BP_3 20.33 0.59 1952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8891 BP_3 6.00 0.93 602 478253184 ENN73555.1 477 1.9e-45 hypothetical protein YQE_09805, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35368 134 4.6e-07 Alpha-1B adrenergic receptor OS=Homo sapiens GN=ADRA1B PE=1 SV=3 PF00001//PF00866 7 transmembrane receptor (rhodopsin family)//Ring hydroxylating beta subunit GO:0007186//GO:0055114//GO:0006725 G-protein coupled receptor signaling pathway//oxidation-reduction process//cellular aromatic compound metabolic process GO:0003824//GO:0004930 catalytic activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.8896 BP_3 57.93 0.66 4535 270006679 EFA03127.1 1763 1.1e-193 hypothetical protein TcasGA2_TC013038 [Tribolium castaneum] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM91 1086 1.4e-116 Tubulin glycylase 3A OS=Drosophila melanogaster GN=TTLL3A PE=1 SV=1 PF03260//PF15966//PF00299//PF07525//PF03133 Lepidopteran low molecular weight (30 kD) lipoprotein//F-box//Squash family serine protease inhibitor//SOCS box//Tubulin-tyrosine ligase family GO:0035556//GO:0006464 intracellular signal transduction//cellular protein modification process GO:0005515//GO:0004867 protein binding//serine-type endopeptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.8897 BP_3 120.23 5.59 1329 642914595 XP_008190278.1 956 1.2e-100 PREDICTED: DNA topoisomerase 2-binding protein 1-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K10728 TOPBP1 topoisomerase (DNA) II binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10728 Q92547 262 1.5e-21 DNA topoisomerase 2-binding protein 1 OS=Homo sapiens GN=TOPBP1 PE=1 SV=3 PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase GO:0009231 riboflavin biosynthetic process GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity -- -- KOG1929 Nucleotide excision repair factor NEF2, RAD4/CUT5 component Cluster-8309.8898 BP_3 32.29 1.41 1398 642914595 XP_008190278.1 953 2.8e-100 PREDICTED: DNA topoisomerase 2-binding protein 1-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K10728 TOPBP1 topoisomerase (DNA) II binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10728 Q92547 262 1.6e-21 DNA topoisomerase 2-binding protein 1 OS=Homo sapiens GN=TOPBP1 PE=1 SV=3 PF00926//PF05975 3,4-dihydroxy-2-butanone 4-phosphate synthase//Bacterial ABC transporter protein EcsB GO:0009231 riboflavin biosynthetic process GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GO:0016021 integral component of membrane KOG1929 Nucleotide excision repair factor NEF2, RAD4/CUT5 component Cluster-8309.8899 BP_3 3.00 1.91 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.89 BP_3 11.00 0.52 1304 478261951 ENN80981.1 455 1.5e-42 hypothetical protein YQE_02606, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8902 BP_3 24.00 1.88 906 478259048 ENN78991.1 666 3.5e-67 hypothetical protein YQE_04542, partial [Dendroctonus ponderosae]>gi|546678361|gb|ERL88994.1| hypothetical protein D910_06372 [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 368 5.2e-34 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.8903 BP_3 242.85 8.46 1676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04636//PF01080 PA26 p53-induced protein (sestrin)//Presenilin GO:1901031 regulation of response to reactive oxygen species GO:0004190 aspartic-type endopeptidase activity GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.8906 BP_3 15.00 1.05 978 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8908 BP_3 80.00 2.54 1812 528477962 XP_003198585.2 347 6.8e-30 PREDICTED: zinc finger protein 665-like [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51508 310 5.5e-27 Zinc finger protein 81 OS=Homo sapiens GN=ZNF81 PE=1 SV=3 PF07776//PF13912//PF03547//PF10426//PF00096//PF00569//PF13465 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Membrane transport protein//Recombination-activating protein 1 zinc-finger domain//Zinc finger, C2H2 type//Zinc finger, ZZ type//Zinc-finger double domain GO:0055085 transmembrane transport GO:0046872//GO:0016881//GO:0008270//GO:0016788 metal ion binding//acid-amino acid ligase activity//zinc ion binding//hydrolase activity, acting on ester bonds GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.8911 BP_3 4.00 0.85 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8912 BP_3 2.00 0.43 515 861651269 KMQ97685.1 283 5.1e-23 endocuticle structural glycoprotein bd-1-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- O02388 256 2.8e-21 Larval cuticle protein LCP-22 OS=Bombyx mori GN=LCP22 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.8915 BP_3 11.26 0.58 1222 91078614 XP_967493.1 640 4.9e-64 PREDICTED: syntaxin-6 [Tribolium castaneum] -- -- -- -- -- K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 Q5R6Q2 278 1.9e-23 Syntaxin-6 OS=Pongo abelii GN=STX6 PE=2 SV=1 PF00957//PF00523//PF05739//PF05478 Synaptobrevin//Fusion glycoprotein F0//SNARE domain//Prominin GO:0006948//GO:0016192 induction by virus of host cell-cell fusion//vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.8916 BP_3 9.00 0.65 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8918 BP_3 11.00 1.85 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00537 Scorpion toxin-like domain GO:0006810 transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.8919 BP_3 12.72 0.37 1928 270001064 EEZ97511.1 158 6.0e-08 hypothetical protein TcasGA2_TC011355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E7FBU4 138 5.1e-07 MMS19 nucleotide excision repair protein homolog OS=Danio rerio GN=mms19 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8923 BP_3 87.33 1.32 3480 642918188 XP_008191403.1 1339 1.2e-144 PREDICTED: adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1 [Tribolium castaneum]>gi|270004524|gb|EFA00972.1| hypothetical protein TcasGA2_TC003883 [Tribolium castaneum] -- -- -- -- -- K15277 SLC35B3, PAPST2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 http://www.genome.jp/dbget-bin/www_bget?ko:K15277 Q29EY2 1017 1.1e-108 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Drosophila pseudoobscura pseudoobscura GN=Papst2 PE=3 SV=2 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1582 UDP-galactose transporter related protein Cluster-8309.8924 BP_3 8.00 0.70 844 321478948 EFX89904.1 381 3.6e-34 hypothetical protein DAPPUDRAFT_230075 [Daphnia pulex] -- -- -- -- -- K03098 APOD apolipoprotein D and lipocalin family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03098 Q8SPI0 280 7.7e-24 Apolipoprotein D OS=Macaca fascicularis GN=APOD PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8925 BP_3 6.66 0.32 1307 675373661 KFM66563.1 238 2.1e-17 Mid1-interacting protein 1-B, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q8AWD1 133 1.3e-06 Mid1-interacting protein 1-like OS=Danio rerio GN=mid1ip1l PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8926 BP_3 17.15 0.67 1524 270006398 EFA02846.1 497 2.3e-47 regulator of telomere elongation helicase 1 [Tribolium castaneum] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 256 8.4e-21 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1132 Helicase of the DEAD superfamily Cluster-8309.893 BP_3 1.00 0.37 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8940 BP_3 98.05 2.91 1915 642938915 XP_008195579.1 1216 1.2e-130 PREDICTED: suppressor APC domain-containing protein 2 [Tribolium castaneum]>gi|270016161|gb|EFA12609.1| hypothetical protein TcasGA2_TC006850 [Tribolium castaneum] 642938914 XM_008197357.1 118 2.1854e-52 PREDICTED: Tribolium castaneum suppressor APC domain-containing protein 2 (LOC660078), mRNA -- -- -- -- Q86UD0 244 2.6e-19 Suppressor APC domain-containing protein 2 OS=Homo sapiens GN=SAPCD2 PE=2 SV=2 PF13405//PF13833 EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.8945 BP_3 17.85 0.39 2498 642939464 XP_008200413.1 1414 1.8e-153 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 647 6.3e-66 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.8948 BP_3 9.00 0.50 1152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8950 BP_3 42.65 0.62 3598 642920186 XP_008192239.1 4407 0.0e+00 PREDICTED: lutropin-choriogonadotropic hormone receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K08399 LGR6 leucine-rich repeat-containing G protein-coupled receptor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08399 D4AC13 1110 1.9e-119 Leucine-rich repeat-containing G-protein coupled receptor 5 OS=Rattus norvegicus GN=Lgr5 PE=3 SV=1 PF13855//PF00560//PF00001 Leucine rich repeat//Leucine Rich Repeat//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.8951 BP_3 16.73 0.47 2015 332372834 AEE61559.1 480 2.9e-45 unknown [Dendroctonus ponderosae]>gi|478263633|gb|ENN81939.1| hypothetical protein YQE_01650, partial [Dendroctonus ponderosae]>gi|546672369|gb|ERL84268.1| hypothetical protein D910_01649 [Dendroctonus ponderosae]>gi|546682306|gb|ERL92259.1| hypothetical protein D910_09576 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D0B6 317 9.4e-28 Protein PBDC1 OS=Mus musculus GN=Pbdc1 PE=2 SV=1 PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase GO:0006725 cellular aromatic compound metabolic process GO:0008198//GO:0016491 ferrous iron binding//oxidoreductase activity -- -- KOG4093 Uncharacterized conserved protein Cluster-8309.8952 BP_3 232.06 6.92 1908 332372834 AEE61559.1 640 7.6e-64 unknown [Dendroctonus ponderosae]>gi|478263633|gb|ENN81939.1| hypothetical protein YQE_01650, partial [Dendroctonus ponderosae]>gi|546672369|gb|ERL84268.1| hypothetical protein D910_01649 [Dendroctonus ponderosae]>gi|546682306|gb|ERL92259.1| hypothetical protein D910_09576 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D0B6 413 6.6e-39 Protein PBDC1 OS=Mus musculus GN=Pbdc1 PE=2 SV=1 PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase GO:0006725 cellular aromatic compound metabolic process GO:0008198//GO:0016491 ferrous iron binding//oxidoreductase activity -- -- KOG4093 Uncharacterized conserved protein Cluster-8309.8954 BP_3 18.53 0.61 1748 642914252 XP_008201607.1 1667 5.7e-183 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|270001550|gb|EEZ97997.1| hypothetical protein TcasGA2_TC000395 [Tribolium castaneum] -- -- -- -- -- K00741 B3GNT1, B3GNT2 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00741 O43505 417 2.1e-39 Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens GN=B4GAT1 PE=1 SV=1 PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.8966 BP_3 12.72 0.53 1447 91086125 XP_968458.1 139 7.2e-06 PREDICTED: EGF-like domain-containing protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09570//PF01601 SinI restriction endonuclease//Coronavirus S2 glycoprotein GO:0046813//GO:0006308//GO:0009307//GO:0061025 receptor-mediated virion attachment to host cell//DNA catabolic process//DNA restriction-modification system//membrane fusion GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359//GO:0019031//GO:0016021 Type II site-specific deoxyribonuclease complex//viral envelope//integral component of membrane -- -- Cluster-8309.8967 BP_3 9.00 0.31 1713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8968 BP_3 55.33 0.95 3085 642917336 XP_008199259.1 1655 2.5e-181 PREDICTED: G-protein coupled receptor family C group 5 member C isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91685 154 1.1e-08 Metabotropic glutamate receptor OS=Drosophila melanogaster GN=mGluR PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.8969 BP_3 346.43 5.84 3151 642917336 XP_008199259.1 1666 1.3e-182 PREDICTED: G-protein coupled receptor family C group 5 member C isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91685 154 1.2e-08 Metabotropic glutamate receptor OS=Drosophila melanogaster GN=mGluR PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.8970 BP_3 165.62 5.76 1677 642917336 XP_008199259.1 1665 9.3e-183 PREDICTED: G-protein coupled receptor family C group 5 member C isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91685 154 6.2e-09 Metabotropic glutamate receptor OS=Drosophila melanogaster GN=mGluR PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.8971 BP_3 451.02 7.92 3037 642917338 XP_008199261.1 1651 7.1e-181 PREDICTED: G-protein coupled receptor family C group 5 member C isoform X2 [Tribolium castaneum]>gi|270004729|gb|EFA01177.1| hypothetical protein TcasGA2_TC010500 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91685 154 1.1e-08 Metabotropic glutamate receptor OS=Drosophila melanogaster GN=mGluR PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.8975 BP_3 33.93 0.50 3584 478250370 ENN70865.1 993 1.7e-104 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672860|gb|ERL84583.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 625 3.2e-63 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF00975//PF07859//PF02230//PF00326//PF01764 Thioesterase domain//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3) GO:0008152//GO:0006508//GO:0009058//GO:0006629 metabolic process//proteolysis//biosynthetic process//lipid metabolic process GO:0016788//GO:0016787//GO:0008236 hydrolase activity, acting on ester bonds//hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.8976 BP_3 11.00 0.45 1466 752863744 XP_011268239.1 246 2.8e-18 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF02796 helix-turn-helix, Psq domain//Helix-turn-helix domain of resolvase GO:0006310 DNA recombination GO:0000150//GO:0003677 recombinase activity//DNA binding -- -- -- -- Cluster-8309.8977 BP_3 2.00 0.47 497 307198987 EFN79714.1 206 4.2e-14 hypothetical protein EAI_06321, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8979 BP_3 21.00 0.52 2250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.898 BP_3 14.24 2.50 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8982 BP_3 27.74 0.58 2615 642937862 XP_008200329.1 2102 3.1e-233 PREDICTED: PHD finger protein 19 [Tribolium castaneum]>gi|270000755|gb|EEZ97202.1| hypothetical protein TcasGA2_TC004391 [Tribolium castaneum] -- -- -- -- -- K11485 MTF2, PCL2 polycomb-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11485 Q9Y483 739 1.4e-76 Metal-response element-binding transcription factor 2 OS=Homo sapiens GN=MTF2 PE=1 SV=2 PF00130//PF05191//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Adenylate kinase, active site lid//PHD-finger GO:0046034//GO:0006144//GO:0035556 ATP metabolic process//purine nucleobase metabolic process//intracellular signal transduction GO:0005515//GO:0004017 protein binding//adenylate kinase activity -- -- -- -- Cluster-8309.8986 BP_3 93.60 1.04 4625 642917080 XP_008191110.1 1932 2.8e-213 PREDICTED: kinesin-like protein KIF18A isoform X2 [Tribolium castaneum] -- -- -- -- -- K10401 KIF18_19 kinesin family member 18/19 http://www.genome.jp/dbget-bin/www_bget?ko:K10401 Q8NI77 1056 4.4e-113 Kinesin-like protein KIF18A OS=Homo sapiens GN=KIF18A PE=1 SV=2 PF04923//PF02245//PF00225 Ninjurin//Methylpurine-DNA glycosylase (MPG)//Kinesin motor domain GO:0042246//GO:0006284//GO:0007018//GO:0007017//GO:0007155 tissue regeneration//base-excision repair//microtubule-based movement//microtubule-based process//cell adhesion GO:0003777//GO:0003905//GO:0003677//GO:0005524//GO:0008017 microtubule motor activity//alkylbase DNA N-glycosylase activity//DNA binding//ATP binding//microtubule binding GO:0045298//GO:0005874//GO:0016021 tubulin complex//microtubule//integral component of membrane KOG0242 Kinesin-like protein Cluster-8309.8987 BP_3 11.00 0.87 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8989 BP_3 392.35 4.80 4233 91078890 XP_973183.1 1472 5.6e-160 PREDICTED: GTP-binding protein Rhes [Tribolium castaneum]>gi|270004145|gb|EFA00593.1| hypothetical protein TcasGA2_TC003464 [Tribolium castaneum] -- -- -- -- -- K07843 RASD1 RAS, dexamethasone-induced Ras-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07843 O35626 616 4.2e-62 Dexamethasone-induced Ras-related protein 1 OS=Mus musculus GN=Rasd1 PE=1 SV=1 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0016020 membrane -- -- Cluster-8309.8990 BP_3 146.66 3.41 2365 91078890 XP_973183.1 1472 3.2e-160 PREDICTED: GTP-binding protein Rhes [Tribolium castaneum]>gi|270004145|gb|EFA00593.1| hypothetical protein TcasGA2_TC003464 [Tribolium castaneum] -- -- -- -- -- K07843 RASD1 RAS, dexamethasone-induced Ras-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07843 O35626 616 2.4e-62 Dexamethasone-induced Ras-related protein 1 OS=Mus musculus GN=Rasd1 PE=1 SV=1 PF00071//PF00025//PF08477 Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0006184 small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0016020 membrane -- -- Cluster-8309.8994 BP_3 1.00 0.76 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8995 BP_3 19.51 0.97 1260 817079938 XP_012262407.1 565 2.5e-55 PREDICTED: U3 small nucleolar ribonucleoprotein protein MPP10 [Athalia rosae] -- -- -- -- -- K14559 MPP10 U3 small nucleolar RNA-associated protein MPP10 http://www.genome.jp/dbget-bin/www_bget?ko:K14559 Q810V0 449 2.9e-43 U3 small nucleolar ribonucleoprotein protein MPP10 OS=Mus musculus GN=Mphosph10 PE=1 SV=2 PF01679//PF04006//PF01896 Proteolipid membrane potential modulator//Mpp10 protein//Eukaryotic and archaeal DNA primase small subunit GO:0006364//GO:0006269//GO:0006351 rRNA processing//DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896 DNA primase activity GO:0005730//GO:0005732//GO:0005657//GO:0005634//GO:0016021//GO:0034457 nucleolus//small nucleolar ribonucleoprotein complex//replication fork//nucleus//integral component of membrane//Mpp10 complex KOG2600 U3 small nucleolar ribonucleoprotein (snoRNP) subunit - Mpp10p Cluster-8309.8996 BP_3 254.49 6.63 2142 91088181 XP_972542.1 1048 4.2e-111 PREDICTED: U3 small nucleolar ribonucleoprotein protein MPP10 [Tribolium castaneum]>gi|270011840|gb|EFA08288.1| hypothetical protein TcasGA2_TC005922 [Tribolium castaneum] -- -- -- -- -- K14559 MPP10 U3 small nucleolar RNA-associated protein MPP10 http://www.genome.jp/dbget-bin/www_bget?ko:K14559 Q810V0 631 3.9e-64 U3 small nucleolar ribonucleoprotein protein MPP10 OS=Mus musculus GN=Mphosph10 PE=1 SV=2 PF04006//PF01679 Mpp10 protein//Proteolipid membrane potential modulator GO:0006364 rRNA processing -- -- GO:0005634//GO:0016021//GO:0005732//GO:0034457 nucleus//integral component of membrane//small nucleolar ribonucleoprotein complex//Mpp10 complex KOG2600 U3 small nucleolar ribonucleoprotein (snoRNP) subunit - Mpp10p Cluster-8309.9 BP_3 9.29 0.99 742 91086999 XP_973764.1 360 8.7e-32 PREDICTED: radial spoke head protein 6 homolog A [Tribolium castaneum]>gi|270009637|gb|EFA06085.1| hypothetical protein TcasGA2_TC008922 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TD94 180 2.7e-12 Radial spoke head protein 4 homolog A OS=Homo sapiens GN=RSPH4A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.90 BP_3 2.00 1.37 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9001 BP_3 91.03 0.44 10240 270011730 EFA08178.1 1458 5.7e-158 hypothetical protein TcasGA2_TC005805 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TN88 338 1.8e-29 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF06160//PF01477//PF05393//PF00520 Septation ring formation regulator, EzrA//PLAT/LH2 domain//Human adenovirus early E3A glycoprotein//Ion transport protein GO:0000921//GO:0055085//GO:0006811 septin ring assembly//transmembrane transport//ion transport GO:0005515//GO:0005216 protein binding//ion channel activity GO:0005940//GO:0016021//GO:0016020 septin ring//integral component of membrane//membrane KOG3599 Ca2+-modulated nonselective cation channel polycystin Cluster-8309.9002 BP_3 1.00 2.02 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9005 BP_3 9.00 0.91 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9010 BP_3 15.50 0.42 2057 91094103 XP_967297.1 1100 3.7e-117 PREDICTED: trafficking protein particle complex subunit 13 [Tribolium castaneum]>gi|270010876|gb|EFA07324.1| hypothetical protein TcasGA2_TC015920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBY7 691 4.1e-71 Trafficking protein particle complex subunit 13 OS=Danio rerio GN=trappc13 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2625 Uncharacterized conserved protein Cluster-8309.9012 BP_3 30.00 0.64 2550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00476 DNA polymerase family A GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.9013 BP_3 18.00 1.70 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9014 BP_3 10.48 0.32 1880 755894611 XP_011295385.1 243 8.1e-18 PREDICTED: probable serine/threonine-protein kinase DDB_G0282963, partial [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9017 BP_3 7.00 0.32 1351 91081791 XP_973848.1 198 9.6e-13 PREDICTED: phospholipase A1 member A isoform X1 [Tribolium castaneum]>gi|270005041|gb|EFA01489.1| hypothetical protein TcasGA2_TC007042 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9018 BP_3 263.70 2.54 5286 270009789 EFA06237.1 1906 3.3e-210 hypothetical protein TcasGA2_TC009087 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G5E8K5 286 9.7e-24 Ankyrin-3 OS=Mus musculus GN=Ank3 PE=1 SV=1 PF00023//PF05509//PF13606//PF08498 Ankyrin repeat//TraY domain//Ankyrin repeat//Sterol methyltransferase C-terminal GO:0000746//GO:0006694 conjugation//steroid biosynthetic process GO:0005515//GO:0008168//GO:0003677 protein binding//methyltransferase activity//DNA binding -- -- -- -- Cluster-8309.9020 BP_3 10.00 3.52 428 642916891 XP_008199544.1 490 4.2e-47 PREDICTED: WASH complex subunit strumpellin [Tribolium castaneum] -- -- -- -- -- K18464 RTSC, SPG8 WASH complex subunit strumpellin http://www.genome.jp/dbget-bin/www_bget?ko:K18464 Q6DIP9 390 6.8e-37 WASH complex subunit strumpellin OS=Xenopus tropicalis PE=2 SV=1 PF10266 Hereditary spastic paraplegia protein strumpellin -- -- -- -- GO:0071203 WASH complex -- -- Cluster-8309.9021 BP_3 1.00 1.08 327 642916891 XP_008199544.1 303 1.5e-25 PREDICTED: WASH complex subunit strumpellin [Tribolium castaneum] -- -- -- -- -- K18464 RTSC, SPG8 WASH complex subunit strumpellin http://www.genome.jp/dbget-bin/www_bget?ko:K18464 Q6DIP9 235 4.9e-19 WASH complex subunit strumpellin OS=Xenopus tropicalis PE=2 SV=1 PF10266 Hereditary spastic paraplegia protein strumpellin -- -- -- -- GO:0071203 WASH complex -- -- Cluster-8309.9022 BP_3 334.00 4.75 3683 270003095 EEZ99542.1 2510 2.1e-280 hypothetical protein TcasGA2_TC000124 [Tribolium castaneum] -- -- -- -- -- K18464 RTSC, SPG8 WASH complex subunit strumpellin http://www.genome.jp/dbget-bin/www_bget?ko:K18464 Q8C2E7 1919 3.0e-213 WASH complex subunit strumpellin OS=Mus musculus GN=Kiaa0196 PE=2 SV=2 PF10266 Hereditary spastic paraplegia protein strumpellin -- -- -- -- GO:0071203 WASH complex KOG3666 Uncharacterized conserved protein Cluster-8309.9024 BP_3 21.00 5.67 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9026 BP_3 3.00 0.67 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03558 TBSV core protein P21/P22 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.9029 BP_3 139.54 2.10 3495 752892473 XP_011264323.1 1503 1.2e-163 PREDICTED: POU domain, class 6, transcription factor 2 isoform X1 [Camponotus floridanus] 817056495 XM_012413689.1 192 2.93639e-93 PREDICTED: Athalia rosae POU domain, class 6, transcription factor 1 (LOC105693636), mRNA K09368 POU6F POU domain transcription factor, class 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09368 Q8BJI4 680 1.3e-69 POU domain, class 6, transcription factor 2 OS=Mus musculus GN=Pou6f2 PE=2 SV=1 PF00046//PF00157 Homeobox domain//Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.9030 BP_3 1.00 5.03 263 817084426 XP_012264865.1 218 8.9e-16 PREDICTED: probable 18S rRNA (guanine-N(7))-methyltransferase isoform X1 [Athalia rosae] -- -- -- -- -- K19306 BUD23 18S rRNA (guanine1575-N7)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K19306 Q9CY21 156 5.7e-10 Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Mus musculus GN=Wbscr22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1541 Predicted protein carboxyl methylase Cluster-8309.9031 BP_3 109.32 1.36 4166 642930054 XP_008196230.1 1395 4.7e-151 PREDICTED: uncharacterized protein LOC662737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 726 7.3e-75 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.9036 BP_3 21.00 0.91 1410 607353959 EZA48640.1 173 8.0e-10 hypothetical protein X777_13603 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9037 BP_3 231.05 3.83 3197 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.904 BP_3 2.63 0.63 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9047 BP_3 10.00 0.52 1210 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9051 BP_3 1.00 0.32 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9056 BP_3 27.67 1.20 1399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9058 BP_3 491.83 5.13 4909 642933323 XP_008197368.1 1156 2.9e-123 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 668 4.6e-68 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.9059 BP_3 3.00 1.15 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9060 BP_3 3.00 1.03 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9068 BP_3 303.00 30.54 770 270009598 EFA06046.1 302 4.8e-25 hypothetical protein TcasGA2_TC008878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08DU8 192 1.1e-13 Biogenesis of lysosome-related organelles complex 1 subunit 6 OS=Bos taurus GN=BLOC1S6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9072 BP_3 2.00 0.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9073 BP_3 3.00 0.34 723 795010007 XP_011864749.1 447 6.9e-42 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9074 BP_3 2.99 0.32 735 795010007 XP_011864749.1 450 3.1e-42 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9076 BP_3 3.01 0.40 654 861599125 KMQ83546.1 286 2.9e-23 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9079 BP_3 38.00 0.70 2904 795014300 XP_011883833.1 733 1.9e-74 PREDICTED: uncharacterized protein LOC105570983, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03872//PF05192 Anti sigma-E protein RseA, N-terminal domain//MutS domain III GO:0006298 mismatch repair GO:0005524//GO:0016989//GO:0030983 ATP binding//sigma factor antagonist activity//mismatched DNA binding -- -- -- -- Cluster-8309.9085 BP_3 6.00 0.40 1006 755973833 XP_011307143.1 297 2.4e-24 PREDICTED: plasminogen activator inhibitor 1 RNA-binding protein-like isoform X4 [Fopius arisanus] -- -- -- -- -- K13199 SERBP1 plasminogen activator inhibitor 1 RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13199 Q9CY58 180 3.6e-12 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2945 Predicted RNA-binding protein Cluster-8309.9088 BP_3 2.00 0.38 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9090 BP_3 8.87 0.56 1059 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF08702//PF12326 Presenilin//Fibrinogen alpha/beta chain family//N-glycosylation protein GO:0030168//GO:0034599//GO:0051258//GO:0007165 platelet activation//cellular response to oxidative stress//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0004190 receptor binding//protein binding, bridging//aspartic-type endopeptidase activity GO:0005577//GO:0005789//GO:0016021 fibrinogen complex//endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.9097 BP_3 32.00 1.13 1655 332373042 AEE61662.1 1012 4.8e-107 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28596 133 1.7e-06 Thyrotropin-releasing hormone receptor OS=Ovis aries GN=TRHR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.91 BP_3 18.00 0.83 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9103 BP_3 2.68 1.71 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9107 BP_3 8.07 0.35 1410 478258279 ENN78408.1 307 2.3e-25 hypothetical protein YQE_05208, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P3S1 176 1.5e-11 DENN domain-containing protein 1B OS=Homo sapiens GN=DENND1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9114 BP_3 4.00 0.50 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.912 BP_3 14.00 0.72 1231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.9121 BP_3 1.00 0.98 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9131 BP_3 29.00 4.13 630 290909033 ADD70031.1 670 8.3e-68 minus-C odorant binding protein 2 [Batocera horsfieldi] 290909032 GU575295.1 429 0 Batocera horsfieldi minus-C odorant binding protein 2 mRNA, complete cds -- -- -- -- P54193 136 2.9e-07 General odorant-binding protein 83a OS=Drosophila melanogaster GN=Obp83a PE=1 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.9138 BP_3 79.00 1.78 2436 478258088 ENN78226.1 809 2.5e-83 hypothetical protein YQE_05377, partial [Dendroctonus ponderosae]>gi|546682772|gb|ERL92661.1| hypothetical protein D910_09973 [Dendroctonus ponderosae] 90101487 DQ416766.1 48 2.28323e-13 Branchiostoma floridae gastrulation brain homeobox (Gbx) mRNA, complete cds K09321 GBX homeobox protein GBX http://www.genome.jp/dbget-bin/www_bget?ko:K09321 Q28ZA9 422 7.6e-40 Homeobox protein unplugged OS=Drosophila pseudoobscura pseudoobscura GN=unpg PE=3 SV=1 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.915 BP_3 1.00 0.86 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9151 BP_3 17.00 0.66 1525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9154 BP_3 2.00 1.84 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9155 BP_3 4.00 0.62 602 270005730 EFA02178.1 368 8.3e-33 hypothetical protein TcasGA2_TC007834 [Tribolium castaneum] 685042659 LN591184.1 35 9.10548e-07 Cyprinus carpio genome assembly common carp genome ,scaffold 000028923 -- -- -- -- Q9VXY2 282 3.2e-24 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.9156 BP_3 30.00 2.04 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9160 BP_3 13.00 4.39 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9164 BP_3 97.53 3.69 1565 642921183 XP_008192750.1 761 5.8e-78 PREDICTED: uncharacterized protein LOC103312840 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9169 BP_3 3.00 0.46 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9170 BP_3 158.03 2.75 3064 546676199 ERL87266.1 878 3.1e-91 hypothetical protein D910_04662 [Dendroctonus ponderosae] -- -- -- -- -- K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 P29981 406 6.8e-38 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.9175 BP_3 49.43 0.95 2800 642934563 XP_008197716.1 3354 0.0e+00 PREDICTED: uncharacterized protein LOC658526 isoform X3 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 454 1.7e-43 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF00096//PF13465//PF02214//PF00651 Zinc finger, C2H2 type//Zinc-finger double domain//BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.9176 BP_3 61.55 1.55 2204 270013728 EFA10176.1 2504 6.3e-280 hypothetical protein TcasGA2_TC012366 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 454 1.3e-43 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.9177 BP_3 70.62 1.47 2609 270013728 EFA10176.1 2268 1.7e-252 hypothetical protein TcasGA2_TC012366 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 454 1.6e-43 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF00651//PF13465//PF00096//PF02214//PF03931 BTB/POZ domain//Zinc-finger double domain//Zinc finger, C2H2 type//BTB/POZ domain//Skp1 family, tetramerisation domain GO:0006511//GO:0051260 ubiquitin-dependent protein catabolic process//protein homooligomerization GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.9178 BP_3 181.45 8.75 1291 642925556 XP_971635.2 1237 3.1e-133 PREDICTED: estrogen sulfotransferase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75897 426 1.4e-40 Sulfotransferase 1C4 OS=Homo sapiens GN=SULT1C4 PE=1 SV=2 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.918 BP_3 33.00 0.83 2205 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9180 BP_3 10.08 0.45 1375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9181 BP_3 6.00 1.41 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9184 BP_3 3.00 93.67 216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9187 BP_3 11.00 0.49 1364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9192 BP_3 2.00 0.47 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9193 BP_3 3.00 0.38 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9196 BP_3 2.00 0.44 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9198 BP_3 75992.00 3338.08 1389 478254345 ENN74597.1 223 1.3e-15 hypothetical protein YQE_08719, partial [Dendroctonus ponderosae] 644995256 XM_001599424.2 164 4.22408e-78 PREDICTED: Nasonia vitripennis histidine-rich glycoprotein (LOC100114466), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9199 BP_3 6.00 2.10 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9200 BP_3 59.00 0.58 5207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04947 Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.9203 BP_3 33.65 0.89 2111 91090228 XP_968551.1 525 1.8e-50 PREDICTED: uncharacterized protein LOC656965 [Tribolium castaneum]>gi|270013773|gb|EFA10221.1| hypothetical protein TcasGA2_TC012417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.921 BP_3 2.00 0.73 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.922 BP_3 8.00 0.37 1330 375173472 AFA42359.1 1579 6.9e-173 clip domain serine proteinase 1 [Portunus trituberculatus] 375173471 JF412648.1 738 0 Portunus trituberculatus clip domain serine proteinase 1 (ClipSP1) mRNA, complete cds K09636 TMPRSS5 transmembrane protease, serine 5 (spinesin) http://www.genome.jp/dbget-bin/www_bget?ko:K09636 P21902 361 4.9e-33 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF06652//PF00089 Methuselah N-terminus//Trypsin GO:0006950//GO:0007186//GO:0006508 response to stress//G-protein coupled receptor signaling pathway//proteolysis GO:0004252//GO:0004930 serine-type endopeptidase activity//G-protein coupled receptor activity -- -- -- -- Cluster-8309.9222 BP_3 2.00 0.59 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9225 BP_3 16.00 0.93 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9228 BP_3 679.06 23.49 1685 642928556 XP_008195374.1 861 1.6e-89 PREDICTED: serine protease easter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 468 2.4e-45 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.9229 BP_3 6.00 0.35 1113 114051800 NP_001040433.1 1118 1.7e-119 eukaryotic translation initiation factor 3 subunit I [Bombyx mori]>gi|121958921|sp|Q1HPW4.1|EIF3I_BOMMO RecName: Full=Eukaryotic translation initiation factor 3 subunit I; Short=eIF3i>gi|95102872|gb|ABF51377.1| eukaryotic translation initiation factor 3 subunit 2 beta [Bombyx mori] 262401080 FJ774721.1 565 0 Scylla paramamosain eukaryotic translation initiation factor 3 mRNA, partial cds K03246 EIF3I translation initiation factor 3 subunit I http://www.genome.jp/dbget-bin/www_bget?ko:K03246 Q1HPW4 1118 6.8e-121 Eukaryotic translation initiation factor 3 subunit I OS=Bombyx mori PE=2 SV=1 PF00400 WD domain, G-beta repeat GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743//GO:0005515 translation initiation factor activity//protein binding GO:0005840//GO:0005737 ribosome//cytoplasm KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) Cluster-8309.923 BP_3 7.83 0.39 1250 478251158 ENN71634.1 591 2.4e-58 hypothetical protein YQE_11732, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843 Herpesvirus tegument protein, N-terminal conserved region GO:0006508 proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-8309.9231 BP_3 150.00 3.67 2264 270007373 EFA03821.1 404 2.1e-36 hypothetical protein TcasGA2_TC013936 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09446 VMA21-like domain GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly -- -- -- -- -- -- Cluster-8309.9232 BP_3 21.19 0.92 1396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9233 BP_3 7.00 0.48 998 642932971 XP_008197211.1 1584 1.4e-173 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] 645037466 XM_008219044.1 415 0 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1472 5.5e-162 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF02214//PF00520 BTB/POZ domain//Ion transport protein GO:0055085//GO:0051260//GO:0006811 transmembrane transport//protein homooligomerization//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.9234 BP_3 14.00 2.62 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9237 BP_3 4.00 0.31 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.924 BP_3 1.00 0.46 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.925 BP_3 14.79 0.32 2486 641660258 XP_008181429.1 905 1.9e-94 PREDICTED: uncharacterized protein LOC103308924 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF04545 Plant transposon protein//Sigma-70, region 4 GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0016987//GO:0003677//GO:0016788 transcription factor activity, sequence-specific DNA binding//sigma factor activity//DNA binding//hydrolase activity, acting on ester bonds GO:0005667 transcription factor complex -- -- Cluster-8309.9250 BP_3 1.00 3.12 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9251 BP_3 1.00 1.55 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9255 BP_3 92.81 0.87 5446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9256 BP_3 31.00 3.24 753 161087399 ABX56859.1 195 1.2e-12 ATP synthase subunit 9 mitochondrial precursor [Litopenaeus vannamei] 338224325 HM217802.1 482 0 Scylla paramamosain ATP synthase c-subunit-like mRNA, partial sequence K02128 ATPeF0C, ATP5G, ATP9 F-type H+-transporting ATPase subunit c http://www.genome.jp/dbget-bin/www_bget?ko:K02128 Q06055 174 1.3e-11 ATP synthase F(0) complex subunit C2, mitochondrial OS=Homo sapiens GN=ATP5G2 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.9259 BP_3 304.71 13.20 1404 642923159 XP_008193634.1 1010 7.0e-107 PREDICTED: uncharacterized protein LOC103313083 isoform X2 [Tribolium castaneum]>gi|270007587|gb|EFA04035.1| hypothetical protein TcasGA2_TC014264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08133 Anticodon nuclease activator family GO:0050792 regulation of viral process GO:0004518 nuclease activity -- -- -- -- Cluster-8309.9264 BP_3 2.00 0.90 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9268 BP_3 12.27 0.40 1754 270006723 EFA03171.1 916 6.9e-96 hypothetical protein TcasGA2_TC013091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 184 2.2e-12 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00001//PF09398//PF00002 7 transmembrane receptor (rhodopsin family)//FOP N terminal dimerisation domain//7 transmembrane receptor (Secretin family) GO:0034453//GO:0007186 microtubule anchoring//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0005815 integral component of membrane//microtubule organizing center -- -- Cluster-8309.9281 BP_3 17.00 0.41 2298 646696832 KDR08860.1 163 1.9e-08 Tumor protein D54 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9284 BP_3 8.00 2.20 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9292 BP_3 6.01 1.40 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.93 BP_3 31.00 0.88 1996 270004805 EFA01253.1 2982 0.0e+00 hypothetical protein TcasGA2_TC002449 [Tribolium castaneum] -- -- -- -- -- K04984 TRPA1, ANKTM1 transient receptor potential cation channel subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04984 Q7Z020 2657 4.3e-299 Transient receptor potential cation channel subfamily A member 1 OS=Drosophila melanogaster GN=TrpA1 PE=2 SV=4 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9302 BP_3 33.16 3.45 755 478254040 ENN74332.1 396 5.9e-36 hypothetical protein YQE_09302, partial [Dendroctonus ponderosae]>gi|546686146|gb|ERL95532.1| hypothetical protein D910_12794 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RDL3 233 1.9e-18 SH3-containing GRB2-like protein 3-interacting protein 1 OS=Pongo abelii GN=SGIP1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9303 BP_3 1.00 2.22 292 478256880 ENN77049.1 134 5.5e-06 hypothetical protein YQE_06385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9305 BP_3 79.32 5.72 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9311 BP_3 15.00 0.59 1526 795017843 XP_011859001.1 451 5.0e-42 PREDICTED: uncharacterized protein LOC105556512 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9313 BP_3 6.00 0.40 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9314 BP_3 14.10 1.01 965 270005505 EFA01953.1 538 2.6e-52 hypothetical protein TcasGA2_TC007569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W440 369 4.2e-34 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.932 BP_3 3.00 0.63 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9321 BP_3 301.13 4.81 3311 512923481 XP_004930363.1 1887 3.3e-208 PREDICTED: protein HIRA homolog [Bombyx mori] -- -- -- -- -- K11293 HIRA, HIR1 protein HIRA/HIR1 http://www.genome.jp/dbget-bin/www_bget?ko:K11293 Q61666 1439 1.2e-157 Protein HIRA OS=Mus musculus GN=Hira PE=1 SV=3 PF00400//PF07569//PF01283 WD domain, G-beta repeat//TUP1-like enhancer of split//Ribosomal protein S26e GO:0006412//GO:0042254//GO:0006355 translation//ribosome biogenesis//regulation of transcription, DNA-templated GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005634//GO:0005622//GO:0005840 nucleus//intracellular//ribosome KOG0973 Histone transcription regulator HIRA, WD repeat superfamily Cluster-8309.9322 BP_3 235.38 4.12 3046 512923481 XP_004930363.1 1820 1.8e-200 PREDICTED: protein HIRA homolog [Bombyx mori] -- -- -- -- -- K11293 HIRA, HIR1 protein HIRA/HIR1 http://www.genome.jp/dbget-bin/www_bget?ko:K11293 Q61666 1439 1.1e-157 Protein HIRA OS=Mus musculus GN=Hira PE=1 SV=3 PF00400//PF07569//PF01283 WD domain, G-beta repeat//TUP1-like enhancer of split//Ribosomal protein S26e GO:0042254//GO:0006355//GO:0006412 ribosome biogenesis//regulation of transcription, DNA-templated//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840//GO:0005634 intracellular//ribosome//nucleus KOG0973 Histone transcription regulator HIRA, WD repeat superfamily Cluster-8309.9325 BP_3 1.00 1.12 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9327 BP_3 0.63 2.42 272 270015441 EFA11889.1 159 6.4e-09 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.933 BP_3 5.00 0.69 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9331 BP_3 11.00 0.94 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02724//PF04851 CDC45-like protein//Type III restriction enzyme, res subunit GO:0006270 DNA replication initiation GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding -- -- -- -- Cluster-8309.9338 BP_3 1.00 0.57 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.934 BP_3 13.00 1.94 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9340 BP_3 5.00 1.36 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9346 BP_3 8.44 0.58 987 642929422 XP_008195833.1 552 6.3e-54 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9347 BP_3 8.00 1.02 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957//PF06450 Commissureless//Bacterial Na+/H+ antiporter B (NhaB) GO:0007411//GO:0006814//GO:0006885//GO:0015992 axon guidance//sodium ion transport//regulation of pH//proton transport GO:0015385 sodium:proton antiporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.9348 BP_3 323.00 32.28 774 189233613 XP_001811691.1 484 3.8e-46 PREDICTED: uncharacterized protein LOC100141910 [Tribolium castaneum]>gi|270014658|gb|EFA11106.1| hypothetical protein TcasGA2_TC004704 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.935 BP_3 5.67 0.37 1031 642922776 XP_008193320.1 264 1.6e-20 PREDICTED: cAMP-dependent protein kinase inhibitor beta-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02827 cAMP-dependent protein kinase inhibitor GO:0045859//GO:0006469 regulation of protein kinase activity//negative regulation of protein kinase activity GO:0004862 cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex -- -- Cluster-8309.9352 BP_3 9.14 0.55 1096 642928744 XP_008199764.1 184 3.3e-11 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X1 [Tribolium castaneum]>gi|642928746|ref|XP_008199765.1| PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.9353 BP_3 108.87 8.42 915 642928748 XP_008199766.1 265 1.1e-20 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K03858 PIGH, GPI15 phosphatidylinositol glycan, class H http://www.genome.jp/dbget-bin/www_bget?ko:K03858 Q14442 151 7.6e-09 Phosphatidylinositol N-acetylglucosaminyltransferase subunit H OS=Homo sapiens GN=PIGH PE=1 SV=1 PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.9361 BP_3 4.82 0.33 1001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9362 BP_3 17.00 0.84 1268 270016741 EFA13187.1 156 6.7e-08 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9363 BP_3 3.00 0.81 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9368 BP_3 330.37 159.13 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9370 BP_3 64.75 1.11 3093 270003283 EEZ99730.1 288 8.1e-23 hypothetical protein TcasGA2_TC002499 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 -- -- -- -- PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.9373 BP_3 139.03 4.16 1902 641664992 XP_008183213.1 994 6.8e-105 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 923 4.8e-98 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF07975//PF00096//PF13465//PF07776//PF16622//PF13912 TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.9378 BP_3 223.26 3.76 3152 576249472 AHH29250.1 3238 0.0e+00 Bedraggled-like protein [Leptinotarsa decemlineata] 576249471 KC713792.1 603 0 Leptinotarsa decemlineata Bedraggled-like protein mRNA, complete cds K05336 SLC6AN solute carrier family 6 (neurotransmitter transporter), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05336 Q99884 256 1.7e-20 Sodium-dependent proline transporter OS=Homo sapiens GN=SLC6A7 PE=2 SV=2 PF11421//PF00209 ATP synthase F1 beta subunit//Sodium:neurotransmitter symporter family GO:0006812//GO:0006754//GO:0006836 cation transport//ATP biosynthetic process//neurotransmitter transport GO:0016887//GO:0005524//GO:0005328 ATPase activity//ATP binding//neurotransmitter:sodium symporter activity GO:0016021//GO:0000275 integral component of membrane//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.9379 BP_3 64.32 3.48 1182 665820376 XP_008559085.1 522 2.3e-50 PREDICTED: uncharacterized protein C15orf61 homolog [Microplitis demolitor]>gi|665820378|ref|XP_008559086.1| PREDICTED: uncharacterized protein C15orf61 homolog [Microplitis demolitor] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 Q0VG49 381 2.1e-35 Uncharacterized protein C15orf61 homolog OS=Mus musculus PE=2 SV=2 PF02055//PF01386 O-Glycosyl hydrolase family 30//Ribosomal L25p family GO:0042254//GO:0006807//GO:0006687//GO:0005975//GO:0006665//GO:0006412 ribosome biogenesis//nitrogen compound metabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//translation GO:0003735//GO:0004348//GO:0008097 structural constituent of ribosome//glucosylceramidase activity//5S rRNA binding GO:0005840 ribosome KOG2566 Beta-glucocerebrosidase Cluster-8309.9383 BP_3 90.00 3.74 1451 675390327 KFM83224.1 393 2.5e-35 Zinc finger protein 850, partial [Stegodyphus mimosarum] -- -- -- -- -- K09230 SCAN SCAN domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09230 B4DXR9 358 1.2e-32 Zinc finger protein 732 OS=Homo sapiens GN=ZNF732 PE=2 SV=1 PF00096//PF13465//PF07776//PF04810//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//Sec23/Sec24 zinc finger//C2H2-type zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0030127//GO:0005634 COPII vesicle coat//nucleus -- -- Cluster-8309.9392 BP_3 8.90 0.62 987 546684320 ERL94025.1 191 4.6e-12 hypothetical protein D910_11309 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9393 BP_3 23.90 0.66 2029 270002917 EEZ99364.1 677 4.1e-68 cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2RRT9 539 1.7e-53 Cytochrome P450 4V2 OS=Rattus norvegicus GN=Cyp4v2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.9398 BP_3 89.20 2.87 1792 91087699 XP_974256.1 900 5.1e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 3.5e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.94 BP_3 17.81 2.04 712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9400 BP_3 8.00 0.36 1360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9404 BP_3 200.71 6.19 1855 642928547 XP_008195370.1 1453 3.9e-158 PREDICTED: protein Wnt-1-like [Tribolium castaneum] -- -- -- -- -- K00408 WNT4 wingless-type MMTV integration site family, member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K00408 P56705 765 9.7e-80 Protein Wnt-4 OS=Homo sapiens GN=WNT4 PE=1 SV=4 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.9406 BP_3 67.90 0.79 4459 546670638 ERL83322.1 788 1.2e-80 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C6L5 135 2.6e-06 Cyclic GMP-AMP synthase OS=Mus musculus GN=Mb21d1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9418 BP_3 15.99 0.61 1561 270002318 EEZ98765.1 614 6.4e-61 hypothetical protein TcasGA2_TC001329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96EX3 187 8.6e-13 WD repeat-containing protein 34 OS=Homo sapiens GN=WDR34 PE=1 SV=2 PF02497//PF12515//PF15184//PF00400 Arterivirus glycoprotein//Ca2+-ATPase N terminal autoinhibitory domain//Mitochondrial import receptor subunit TOM6 homolog//WD domain, G-beta repeat -- -- GO:0005516//GO:0005515 calmodulin binding//protein binding GO:0005742//GO:0019031 mitochondrial outer membrane translocase complex//viral envelope -- -- Cluster-8309.9426 BP_3 4.00 10.62 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9427 BP_3 9.00 2.79 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9429 BP_3 1322.89 39.94 1888 642910784 XP_008193408.1 297 4.5e-24 PREDICTED: PAX-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90WJ3 143 1.3e-07 PAX-interacting protein 1 OS=Xenopus laevis GN=paxip1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9430 BP_3 9.30 0.69 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9437 BP_3 229.00 5.37 2349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.944 BP_3 15.00 0.75 1261 478261021 ENN80601.1 583 2.0e-57 hypothetical protein YQE_02980, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9443 BP_3 18.28 1.25 999 270016304 EFA12750.1 198 7.1e-13 hypothetical protein TcasGA2_TC010277 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9444 BP_3 2.00 0.45 508 662215753 XP_008481775.1 347 1.9e-30 PREDICTED: uncharacterized protein LOC103518486 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P04323 291 2.4e-25 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9445 BP_3 24.60 0.64 2145 25167081 AAN73844.1 311 1.2e-25 reverse transcriptase/RNaseH [Solenopsis invicta] -- -- -- -- -- -- -- -- -- P20825 246 1.7e-19 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00844//PF03367 Geminivirus coat protein/nuclear export factor BR1 family//ZPR1 zinc-finger domain -- -- GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.9447 BP_3 4.00 0.33 874 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9448 BP_3 109.29 8.58 906 91086029 XP_973201.1 551 7.5e-54 PREDICTED: origin recognition complex subunit 6 [Tribolium castaneum]>gi|270009926|gb|EFA06374.1| hypothetical protein TcasGA2_TC009250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y1B2 300 3.9e-26 Origin recognition complex subunit 6 OS=Drosophila melanogaster GN=Orc6 PE=1 SV=2 PF05460//PF00382//PF05615//PF00420 Origin recognition complex subunit 6 (ORC6)//Transcription factor TFIIB repeat//Tho complex subunit 7//NADH-ubiquinone/plastoquinone oxidoreductase chain 4L GO:0042773//GO:0006397//GO:0055114//GO:0006260 ATP synthesis coupled electron transport//mRNA processing//oxidation-reduction process//DNA replication GO:0016651//GO:0003677//GO:0017025 oxidoreductase activity, acting on NAD(P)H//DNA binding//TBP-class protein binding GO:0005664//GO:0000445 nuclear origin of replication recognition complex//THO complex part of transcription export complex KOG4557 Origin recognition complex, subunit 6 Cluster-8309.9450 BP_3 51.74 1.16 2441 642934658 XP_008197755.1 2041 3.4e-226 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 4.91771e-15 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 503 3.1e-49 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9451 BP_3 552.60 79.67 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9455 BP_3 6.00 0.31 1229 478250862 ENN71351.1 728 3.1e-74 hypothetical protein YQE_11966, partial [Dendroctonus ponderosae]>gi|546685629|gb|ERL95105.1| hypothetical protein D910_12375 [Dendroctonus ponderosae] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q6PA23 349 1.1e-31 Lipase member H-A OS=Xenopus laevis GN=liph-a PE=2 SV=1 PF01764 Lipase (class 3) GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.9460 BP_3 12.00 0.53 1382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643 B-box zinc finger -- -- GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.9467 BP_3 26.00 2.02 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9468 BP_3 7.45 0.67 825 780704567 XP_011702891.1 435 1.9e-40 PREDICTED: probable G-protein coupled receptor No9 isoform X2 [Wasmannia auropunctata] -- -- -- -- -- K04165 Oamb Octopamine receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04165 Q93126 340 8.3e-31 Probable G-protein coupled receptor No9 OS=Amphibalanus amphitrite PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.9470 BP_3 19.00 1.61 860 642930467 XP_008196414.1 325 1.1e-27 PREDICTED: exosome complex component RRP46 [Tribolium castaneum] -- -- -- -- -- K12590 RRP46, EXOSC5 exosome complex component RRP46 http://www.genome.jp/dbget-bin/www_bget?ko:K12590 Q9NQT4 169 5.8e-11 Exosome complex component RRP46 OS=Homo sapiens GN=EXOSC5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1069 Exosomal 3'-5' exoribonuclease complex, subunit Rrp46 Cluster-8309.9472 BP_3 10.00 0.39 1532 642917362 XP_008199271.1 499 1.4e-47 PREDICTED: probable palmitoyltransferase ZDHHC1 [Tribolium castaneum] 642917361 XM_008201049.1 234 5.70886e-117 PREDICTED: Tribolium castaneum probable palmitoyltransferase ZDHHC1 (LOC655963), mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9H8X9 279 1.8e-23 Probable palmitoyltransferase ZDHHC11 OS=Homo sapiens GN=ZDHHC11 PE=2 SV=1 PF00335//PF01529 Tetraspanin family//DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding GO:0016021 integral component of membrane KOG1311 DHHC-type Zn-finger proteins Cluster-8309.9473 BP_3 4.35 4.19 334 642917260 XP_008199225.1 145 3.3e-07 PREDICTED: uncharacterized protein LOC103314591 isoform X1 [Tribolium castaneum]>gi|270004754|gb|EFA01202.1| hypothetical protein TcasGA2_TC010529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9475 BP_3 12.65 1.91 610 642917260 XP_008199225.1 178 9.1e-11 PREDICTED: uncharacterized protein LOC103314591 isoform X1 [Tribolium castaneum]>gi|270004754|gb|EFA01202.1| hypothetical protein TcasGA2_TC010529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9476 BP_3 31.42 0.51 3290 270004746 EFA01194.1 282 4.3e-22 hypothetical protein TcasGA2_TC010521 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9483 BP_3 190.57 4.53 2319 642914671 XP_008190309.1 831 6.6e-86 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 401 2.0e-37 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.9484 BP_3 2.00 0.38 545 642924686 XP_008194398.1 212 9.2e-15 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9485 BP_3 2.00 0.54 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9496 BP_3 97562.78 2642.91 2071 189237068 XP_001809825.1 354 1.2e-30 PREDICTED: cuticle protein 7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 267 6.1e-22 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF03870//PF00379 RNA polymerase Rpb8//Insect cuticle protein GO:0006351 transcription, DNA-templated GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.9504 BP_3 140.00 16.45 702 91080607 XP_967476.1 164 4.4e-09 PREDICTED: zonadhesin [Tribolium castaneum]>gi|270005833|gb|EFA02281.1| hypothetical protein TcasGA2_TC007945 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46202 128 2.7e-06 Accessory gland protein Acp62F OS=Drosophila melanogaster GN=Acp62F PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9506 BP_3 116.70 6.77 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9509 BP_3 26.75 0.51 2838 642917326 XP_008199254.1 384 5.5e-34 PREDICTED: kazrin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09482 Bacterial type III secretion apparatus protein (OrgA_MxiK) GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.951 BP_3 143.00 11.09 913 91086899 XP_970867.1 637 8.1e-64 PREDICTED: ubiquitin-conjugating enzyme E2 T [Tribolium castaneum]>gi|270009677|gb|EFA06125.1| hypothetical protein TcasGA2_TC008968 [Tribolium castaneum] -- -- -- -- -- K13960 UBE2T, HSPC150 ubiquitin-conjugating enzyme E2 T http://www.genome.jp/dbget-bin/www_bget?ko:K13960 Q9NPD8 452 9.4e-44 Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens GN=UBE2T PE=1 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0005524//GO:0016881//GO:0005515 ATP binding//acid-amino acid ligase activity//protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.9513 BP_3 41.96 2.25 1189 668453032 KFB41786.1 893 2.2e-93 AGAP003352-PB-like protein [Anopheles sinensis] -- -- -- -- -- K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q9VZA4 780 1.1e-81 Band 7 protein CG42540 OS=Drosophila melanogaster GN=CG42540 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.9518 BP_3 63.99 0.80 4156 751234819 XP_011171162.1 407 1.7e-36 PREDICTED: uncharacterized protein LOC105203928 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05125//PF05485 Phage major capsid protein, P2 family//THAP domain -- -- GO:0003676 nucleic acid binding GO:0019028 viral capsid -- -- Cluster-8309.952 BP_3 8.00 0.92 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9528 BP_3 8.11 0.64 898 728418700 AIY68378.1 416 3.4e-38 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- K15743 CES3_5 carboxylesterase 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15743 P35502 248 4.2e-20 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06973//PF00326//PF07859 Domain of unknown function (DUF1297)//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152//GO:0006188 proteolysis//metabolic process//IMP biosynthetic process GO:0000287//GO:0008236//GO:0005524//GO:0016787//GO:0016879 magnesium ion binding//serine-type peptidase activity//ATP binding//hydrolase activity//ligase activity, forming carbon-nitrogen bonds -- -- -- -- Cluster-8309.953 BP_3 25.60 1.04 1477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q3ZCU0 132 2.0e-06 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9546 BP_3 14.47 0.61 1443 795094282 XP_011879929.1 643 2.6e-64 PREDICTED: uncharacterized protein LOC105568681 [Vollenhovia emeryi] 817183960 XM_012423831.1 174 1.21268e-83 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9547 BP_3 3.00 0.69 502 759074866 XP_011347129.1 239 6.3e-18 PREDICTED: uncharacterized protein LOC105284944 isoform X1 [Cerapachys biroi] 498954172 XM_004523564.1 83 1.56031e-33 PREDICTED: Ceratitis capitata uncharacterized LOC101462215 (LOC101462215), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.955 BP_3 30.09 0.69 2402 642919385 XP_008191851.1 1996 5.5e-221 PREDICTED: synaptotagmin-5 isoform X2 [Tribolium castaneum] 768449804 XM_011568704.1 71 3.68745e-26 PREDICTED: Plutella xylostella synaptotagmin-5-like (LOC105396697), partial mRNA -- -- -- -- Q9R0N8 502 4.0e-49 Synaptotagmin-6 OS=Mus musculus GN=Syt6 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.9550 BP_3 214.60 3.49 3252 642917336 XP_008199259.1 1710 1.1e-187 PREDICTED: G-protein coupled receptor family C group 5 member C isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91685 154 1.2e-08 Metabotropic glutamate receptor OS=Drosophila melanogaster GN=mGluR PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.9555 BP_3 7.00 0.32 1348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9558 BP_3 42.56 0.87 2662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9559 BP_3 4.00 2.20 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9564 BP_3 148.91 5.49 1600 642912288 XP_008200636.1 687 2.3e-69 PREDICTED: venom protease-like [Tribolium castaneum]>gi|270002898|gb|EEZ99345.1| serine protease P56 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 537 2.3e-53 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF08449//PF00089 UAA transporter family//Trypsin GO:0006508//GO:0055085 proteolysis//transmembrane transport GO:0016787//GO:0004252 hydrolase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.9571 BP_3 28.93 0.48 3169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03851//PF06385 UV-endonuclease UvdE//Baculovirus LEF-11 protein GO:0019058//GO:0006289//GO:0006355//GO:0009411 viral life cycle//nucleotide-excision repair//regulation of transcription, DNA-templated//response to UV GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.9573 BP_3 112.89 2.84 2209 332375106 AEE62694.1 744 7.7e-76 unknown [Dendroctonus ponderosae] 332375105 BT127732.1 396 0 Dendroctonus ponderosae clone DPO119_L10 unknown mRNA -- -- -- -- B0BN95 157 3.7e-09 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.9574 BP_3 3.00 1.70 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08752 Coatomer gamma subunit appendage platform subdomain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198 structural molecule activity GO:0030126 COPI vesicle coat -- -- Cluster-8309.9578 BP_3 8.00 0.70 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9586 BP_3 97.75 0.70 6988 546671289 ERL83664.1 3798 0.0e+00 hypothetical protein D910_00834 [Dendroctonus ponderosae]>gi|546671392|gb|ERL83721.1| hypothetical protein D910_00934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00424//PF01520 REV protein (anti-repression trans-activator protein)//N-acetylmuramoyl-L-alanine amidase GO:0006355//GO:0009252//GO:0006807//GO:0009253 regulation of transcription, DNA-templated//peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0008745//GO:0003700 N-acetylmuramoyl-L-alanine amidase activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex -- -- Cluster-8309.9587 BP_3 46.25 0.34 6924 546671289 ERL83664.1 3798 0.0e+00 hypothetical protein D910_00834 [Dendroctonus ponderosae]>gi|546671392|gb|ERL83721.1| hypothetical protein D910_00934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00424//PF01520 REV protein (anti-repression trans-activator protein)//N-acetylmuramoyl-L-alanine amidase GO:0006355//GO:0006807//GO:0009252//GO:0009253 regulation of transcription, DNA-templated//nitrogen compound metabolic process//peptidoglycan biosynthetic process//peptidoglycan catabolic process GO:0008745//GO:0003700 N-acetylmuramoyl-L-alanine amidase activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex -- -- Cluster-8309.9589 BP_3 2.00 0.68 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.959 BP_3 6.00 0.34 1144 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9591 BP_3 8.00 0.32 1500 270015497 EFA11945.1 395 1.5e-35 hypothetical protein TcasGA2_TC001903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53849 139 3.1e-07 Zinc finger protein GIS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GIS2 PE=1 SV=1 PF03391//PF00098 Nepovirus coat protein, central domain//Zinc knuckle -- -- GO:0005198//GO:0003676//GO:0008270 structural molecule activity//nucleic acid binding//zinc ion binding GO:0019028 viral capsid KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.9592 BP_3 5.00 0.59 702 270016094 EFA12542.1 139 3.5e-06 hypothetical protein TcasGA2_TC016067 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07544//PF04111 RNA polymerase II transcription mediator complex subunit 9//Autophagy protein Apg6 GO:0006914//GO:0006357 autophagy//regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.9593 BP_3 39.18 0.61 3377 642921163 XP_008192741.1 2293 2.8e-255 PREDICTED: sip1/TFIP11 interacting protein isoform X1 [Tribolium castaneum]>gi|270006305|gb|EFA02753.1| hypothetical protein TcasGA2_TC008486 [Tribolium castaneum] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q0IIX9 1225 8.1e-133 Tuftelin-interacting protein 11 OS=Xenopus tropicalis GN=tfip11 PE=2 SV=2 PF01585//PF07842 G-patch domain//GC-rich sequence DNA-binding factor-like protein GO:0008380//GO:0006397//GO:0006355 RNA splicing//mRNA processing//regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0005681//GO:0005634 spliceosomal complex//nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.9595 BP_3 16.00 7.93 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9599 BP_3 8.93 0.84 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.96 BP_3 11.00 0.33 1878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.960 BP_3 2.00 0.40 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9601 BP_3 18.86 0.46 2251 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9603 BP_3 15.00 0.71 1304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.961 BP_3 18620.00 2569.33 641 817201162 XP_012276323.1 139 3.2e-06 PREDICTED: spidroin-1-like isoform X2 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11593 Mediator complex subunit 3 fungal GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.9611 BP_3 19.16 0.67 1678 478255874 ENN76082.1 2237 4.4e-249 hypothetical protein YQE_07453, partial [Dendroctonus ponderosae]>gi|546680435|gb|ERL90701.1| hypothetical protein D910_08048 [Dendroctonus ponderosae] -- -- -- -- -- K12847 USP39, SAD1 U4/U6.U5 tri-snRNP-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12847 Q3TIX9 1750 5.3e-194 U4/U6.U5 tri-snRNP-associated protein 2 OS=Mus musculus GN=Usp39 PE=2 SV=2 PF02148//PF00443//PF00738 Zn-finger in ubiquitin-hydrolases and other protein//Ubiquitin carboxyl-terminal hydrolase//Polyhedrin GO:0016579 protein deubiquitination GO:0036459//GO:0008270//GO:0005198 ubiquitinyl hydrolase activity//zinc ion binding//structural molecule activity -- -- KOG2026 Spindle pole body protein - Sad1p Cluster-8309.9614 BP_3 37.33 0.61 3221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9617 BP_3 24.84 0.59 2330 642934179 XP_008199640.1 710 7.1e-72 PREDICTED: uncharacterized protein LOC657682 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZMT1 173 5.4e-11 SH3 and cysteine-rich domain-containing protein 2 OS=Homo sapiens GN=STAC2 PE=1 SV=1 PF00628//PF07649//PF00130 PHD-finger//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0047134//GO:0005515 protein-disulfide reductase activity//protein binding -- -- -- -- Cluster-8309.962 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9620 BP_3 14.00 1.30 810 325297037 NP_001191522.1 532 1.1e-51 ribosomal protein L27a [Aplysia californica]>gi|256550152|gb|ACU83596.1| ribosomal protein L27a [Aplysia californica] 697087783 XM_009658508.1 450 0 Verticillium dahliae VdLs.17 60S ribosomal protein L27a partial mRNA K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 P78987 710 1.0e-73 60S ribosomal protein L27a OS=Blumeria graminis f. sp. hordei PE=2 SV=1 -- -- -- -- -- -- GO:0030529 intracellular ribonucleoprotein complex KOG1742 60s ribosomal protein L15/L27 Cluster-8309.963 BP_3 150.48 5.94 1513 270004813 EFA01261.1 524 1.7e-50 cytochrome P450 303A1 [Tribolium castaneum] -- -- -- -- -- K07418 CYP2J cytochrome P450, family 2, subfamily J http://www.genome.jp/dbget-bin/www_bget?ko:K07418 Q9V399 324 1.1e-28 Probable cytochrome P450 303a1 OS=Drosophila melanogaster GN=Cyp303a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.9631 BP_3 86.69 0.90 4910 91092640 XP_969145.1 1718 2.0e-188 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K11445 KDM7A, JHDM1D lysine-specific demethylase 7A http://www.genome.jp/dbget-bin/www_bget?ko:K11445 Q5RHD1 805 5.9e-84 Lysine-specific demethylase 7A OS=Danio rerio GN=kdm7a PE=2 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.9632 BP_3 5.00 0.49 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9634 BP_3 23.00 0.37 3256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04512 Baculovirus polyhedron envelope protein, PEP, N terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid -- -- Cluster-8309.9635 BP_3 64.00 1.57 2254 167466209 NP_001034503.2 1710 7.6e-188 fork head [Tribolium castaneum]>gi|270008139|gb|EFA04587.1| fork head [Tribolium castaneum] 462360555 APGK01029353.1 157 5.38951e-74 Dendroctonus ponderosae Seq01029363, whole genome shotgun sequence K08035 FOXA2, HNF3B forkhead box protein A2, hepatocyte nuclear factor 3-beta http://www.genome.jp/dbget-bin/www_bget?ko:K08035 P14734 975 5.3e-104 Protein fork head OS=Drosophila melanogaster GN=fkh PE=1 SV=1 PF00250//PF08430 Forkhead domain//Forkhead N-terminal region GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0019904//GO:0008134//GO:0003700 sequence-specific DNA binding//protein domain specific binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3563 Forkhead/HNF-3-related transcription factor Cluster-8309.9637 BP_3 10.19 0.64 1059 795012426 XP_011878089.1 228 2.5e-16 PREDICTED: uncharacterized protein LOC105567651, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9644 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9649 BP_3 1.00 0.39 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9660 BP_3 60.00 3.13 1216 307212038 EFN87922.1 251 6.2e-19 hypothetical protein EAI_08475, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9663 BP_3 11.08 0.88 899 642913250 XP_008201456.1 919 1.6e-96 PREDICTED: probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum] 585692231 XM_006821346.1 60 1.75609e-20 PREDICTED: Saccoglossus kowalevskii probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase-like (LOC102807371), mRNA K03849 ALG8 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03849 Q9BVK2 645 3.9e-66 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Homo sapiens GN=ALG8 PE=1 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG2576 Glucosyltransferase - Alg8p Cluster-8309.9667 BP_3 1.00 0.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9672 BP_3 56.74 0.82 3643 91093355 XP_969078.1 1693 1.1e-185 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IWG1 496 3.0e-48 WD repeat-containing protein 63 OS=Homo sapiens GN=WDR63 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.9674 BP_3 87.74 0.78 5725 662195961 XP_008470989.1 958 3.0e-100 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9675 BP_3 421.44 4.56 4745 189240461 XP_973773.2 5639 0.0e+00 PREDICTED: intraflagellar transport protein 140 homolog [Tribolium castaneum]>gi|270012537|gb|EFA08985.1| hypothetical protein TcasGA2_TC006692 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RY7 2485 8.9e-279 Intraflagellar transport protein 140 homolog OS=Homo sapiens GN=IFT140 PE=1 SV=1 PF00515//PF13374//PF13181//PF13176//PF00637//PF04053//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Region in Clathrin and VPS//Coatomer WD associated region//TPR repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG3617 WD40 and TPR repeat-containing protein Cluster-8309.9678 BP_3 1.00 1.16 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9685 BP_3 4.00 0.85 519 270016078 EFA12526.1 149 1.8e-07 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.9687 BP_3 165.87 7.44 1366 642912341 XP_008199603.1 1414 9.7e-154 PREDICTED: DNA polymerase delta catalytic subunit [Tribolium castaneum]>gi|270002921|gb|EEZ99368.1| DNA polymerase delta [Tribolium castaneum] 324120767 AB598735.1 66 1.24793e-23 Ctenocephalides felis DPD1 mRNA for DNA polymerase delta catalytic subunit, partial cds, isolate: 53 K02327 POLD1 DNA polymerase delta subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02327 P54358 975 3.2e-104 DNA polymerase delta catalytic subunit OS=Drosophila melanogaster GN=DNApol-delta PE=2 SV=2 PF03104 DNA polymerase family B, exonuclease domain GO:0006260 DNA replication GO:0003887//GO:0000166//GO:0003677//GO:0008408 DNA-directed DNA polymerase activity//nucleotide binding//DNA binding//3'-5' exonuclease activity GO:0042575 DNA polymerase complex KOG0969 DNA polymerase delta, catalytic subunit Cluster-8309.9688 BP_3 31.13 5.92 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9689 BP_3 29.88 1.58 1204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9690 BP_3 16.64 0.55 1751 642938314 XP_008192827.1 219 4.6e-15 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X7 [Tribolium castaneum] -- -- -- -- -- K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 -- -- -- -- PF04947 Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.970 BP_3 10.64 0.72 1004 478259305 ENN79207.1 677 2.0e-68 hypothetical protein YQE_04391, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H1X1 361 3.7e-33 Radial spoke head protein 9 homolog OS=Homo sapiens GN=RSPH9 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9700 BP_3 1.00 0.39 415 669215019 CDW61002.1 141 1.2e-06 Cell wall-associated hydrolase [Trichuris trichiura] 297180788 GU474852.1 300 2.98171e-154 Uncultured Vibrionales bacterium HF0010_22E23 genomic sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9703 BP_3 7.00 0.54 918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.971 BP_3 3.00 0.43 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9712 BP_3 26.51 1.98 938 641669667 XP_008184906.1 223 8.4e-16 PREDICTED: uncharacterized protein LOC100574215 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9716 BP_3 58.03 0.76 3985 641661038 XP_008181718.1 1176 1.1e-125 PREDICTED: uncharacterized protein LOC103309021 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609//PF08144//PF02944 Plant transposon protein//Transposase DDE domain//CPL (NUC119) domain//BESS motif GO:0006313 transposition, DNA-mediated GO:0004803//GO:0016788//GO:0003723//GO:0003677 transposase activity//hydrolase activity, acting on ester bonds//RNA binding//DNA binding -- -- -- -- Cluster-8309.9717 BP_3 3.00 0.39 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9718 BP_3 7.00 0.45 1049 546673028 ERL84714.1 812 4.7e-84 hypothetical protein D910_02139 [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 O61369 410 8.0e-39 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.9719 BP_3 3.00 0.31 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9722 BP_3 0.90 0.50 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9724 BP_3 21.41 0.66 1864 642923022 XP_008200499.1 709 7.4e-72 PREDICTED: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62377 381 3.3e-35 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 OS=Mus musculus GN=Zrsr2 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2202 U2 snRNP splicing factor, small subunit, and related proteins Cluster-8309.9735 BP_3 110.39 7.81 973 91079010 XP_974804.1 425 3.3e-39 PREDICTED: putative inositol monophosphatase 3 [Tribolium castaneum]>gi|270004173|gb|EFA00621.1| hypothetical protein TcasGA2_TC003497 [Tribolium castaneum] -- -- -- -- -- K15759 IMPAD1, IMPA3 inositol monophosphatase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15759 Q9VYF2 297 9.4e-26 Putative inositol monophosphatase 3 OS=Drosophila melanogaster GN=CG15743 PE=2 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.9737 BP_3 1.00 0.46 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.974 BP_3 4.83 0.53 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9741 BP_3 8.00 1.66 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9743 BP_3 31.01 0.40 4001 91090840 XP_972191.1 181 2.7e-10 PREDICTED: N-acetyl-D-glucosamine kinase [Tribolium castaneum]>gi|270013990|gb|EFA10438.1| hypothetical protein TcasGA2_TC012681 [Tribolium castaneum] -- -- -- -- -- K00884 NAGK, nagK N-acetylglucosamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9745 BP_3 2.00 0.42 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9746 BP_3 3.00 1.42 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9748 BP_3 4.78 0.32 1019 478251807 ENN72253.1 849 2.4e-88 hypothetical protein YQE_11116, partial [Dendroctonus ponderosae]>gi|546684744|gb|ERL94354.1| hypothetical protein D910_11635 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AXS8 266 3.9e-22 Tubulin polyglutamylase complex subunit 2 OS=Rattus norvegicus GN=Tpgs2 PE=2 SV=2 PF00325 Bacterial regulatory proteins, crp family GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.9749 BP_3 131.57 16.04 687 780705582 XP_011703132.1 569 4.7e-56 PREDICTED: UPF0585 protein C16orf13 homolog A isoform X2 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- Q9VLF6 500 1.9e-49 UPF0585 protein CG18661 OS=Drosophila melanogaster GN=CG18661 PE=2 SV=2 PF08241 Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.9750 BP_3 8.65 0.53 1078 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9751 BP_3 42.16 0.96 2406 642919042 XP_008191709.1 435 5.7e-40 PREDICTED: hyaluronan mediated motility receptor-like [Tribolium castaneum]>gi|270005720|gb|EFA02168.1| hypothetical protein TcasGA2_TC007824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- F4HZB5 246 1.9e-19 Protein NETWORKED 1D OS=Arabidopsis thaliana GN=NET1D PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9752 BP_3 9.00 0.95 750 642919042 XP_008191709.1 288 2.0e-23 PREDICTED: hyaluronan mediated motility receptor-like [Tribolium castaneum]>gi|270005720|gb|EFA02168.1| hypothetical protein TcasGA2_TC007824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836//PF04111//PF00815//PF02601 RasGAP C-terminus//Autophagy protein Apg6//Histidinol dehydrogenase//Exonuclease VII, large subunit GO:0000105//GO:0055114//GO:0007264//GO:0006308//GO:0006914 histidine biosynthetic process//oxidation-reduction process//small GTPase mediated signal transduction//DNA catabolic process//autophagy GO:0008270//GO:0004399//GO:0051287//GO:0008855//GO:0005096 zinc ion binding//histidinol dehydrogenase activity//NAD binding//exodeoxyribonuclease VII activity//GTPase activator activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.9753 BP_3 3.00 0.98 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9756 BP_3 74.41 1.64 2474 795019186 XP_011859494.1 201 7.9e-13 PREDICTED: uncharacterized protein LOC105556985 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.976 BP_3 18.69 0.53 1978 642911863 XP_008200779.1 1219 5.7e-131 PREDICTED: uncharacterized protein LOC660579 [Tribolium castaneum] 313505767 HM562967.1 74 6.50595e-28 Spodoptera littoralis putative chemosensory ionotropic receptor IR21a mRNA, complete cds -- -- -- -- Q16099 160 1.5e-09 Glutamate receptor ionotropic, kainate 4 OS=Homo sapiens GN=GRIK4 PE=2 SV=2 PF00060 Ligand-gated ion channel GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0004970 ionotropic glutamate receptor activity GO:0016020 membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-8309.9762 BP_3 5.00 0.48 793 381234574 AFF76545.1 799 1.2e-82 cytochrome c oxidase subunit II (mitochondrion) [Homo sapiens] 893712393 KT250561.1 792 0 Homo sapiens haplogroup H5a6 mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P00403 798 6.2e-84 Cytochrome c oxidase subunit 2 OS=Homo sapiens GN=MT-CO2 PE=1 SV=1 PF02790//PF05434 Cytochrome C oxidase subunit II, transmembrane domain//TMEM9 GO:0022900 electron transport chain -- -- GO:0016021 integral component of membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.9770 BP_3 2.00 0.37 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9777 BP_3 2.00 0.49 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9778 BP_3 45.00 3.48 915 311739209 ADQ01809.1 1201 3.2e-129 opsin protein [Uca pugilator] 311739208 HM765425.1 405 0 Celuca pugilator opsin protein (Rh1) mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 1183 1.6e-128 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.9779 BP_3 11.00 2.13 541 253464615 ACT31580.1 503 1.7e-48 opsin 1 [Uca vomeris] 829042 D50583.1 253 5.30188e-128 Hemigrapsus sanguineus mRNA for opsin BcRh1, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 516 2.1e-51 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.9780 BP_3 3.00 1.24 407 311739209 ADQ01809.1 419 6.8e-39 opsin protein [Uca pugilator] 829042 D50583.1 228 3.08925e-114 Hemigrapsus sanguineus mRNA for opsin BcRh1, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 425 5.7e-41 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.9791 BP_3 118.91 0.88 6797 642918714 XP_008191551.1 2723 7.9e-305 PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|642918716|ref|XP_008191552.1| PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|270005665|gb|EFA02113.1| hypothetical protein TcasGA2_TC007759 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 Q13393 1322 9.2e-144 Phospholipase D1 OS=Homo sapiens GN=PLD1 PE=1 SV=1 PF00614//PF00787//PF02399 Phospholipase D Active site motif//PX domain//Origin of replication binding protein GO:0006260//GO:0007154//GO:0008152 DNA replication//cell communication//metabolic process GO:0003688//GO:0003824//GO:0005524//GO:0035091 DNA replication origin binding//catalytic activity//ATP binding//phosphatidylinositol binding GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.9792 BP_3 74.52 1.37 2914 642918712 XP_008191550.1 1991 2.6e-220 PREDICTED: phospholipase D2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 Q13393 978 3.1e-104 Phospholipase D1 OS=Homo sapiens GN=PLD1 PE=1 SV=1 PF00614//PF00787//PF02399 Phospholipase D Active site motif//PX domain//Origin of replication binding protein GO:0006260 DNA replication GO:0035091//GO:0003824//GO:0005524//GO:0003688 phosphatidylinositol binding//catalytic activity//ATP binding//DNA replication origin binding GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.9794 BP_3 5.00 0.41 878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9796 BP_3 4.00 0.32 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9797 BP_3 48.79 2.98 1082 91082291 XP_973881.1 1084 1.4e-115 PREDICTED: probable tRNA pseudouridine synthase 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGG2 494 1.5e-48 Probable tRNA pseudouridine synthase 2 OS=Xenopus tropicalis GN=trub2 PE=2 SV=1 PF01509 TruB family pseudouridylate synthase (N terminal domain) GO:0006396 RNA processing -- -- -- -- KOG2559 Predicted pseudouridine synthase Cluster-8309.9806 BP_3 5.00 0.36 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9810 BP_3 13.33 0.36 2083 91090840 XP_972191.1 372 9.9e-33 PREDICTED: N-acetyl-D-glucosamine kinase [Tribolium castaneum]>gi|270013990|gb|EFA10438.1| hypothetical protein TcasGA2_TC012681 [Tribolium castaneum] -- -- -- -- -- K00884 NAGK, nagK N-acetylglucosamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00884 Q9QZ08 234 4.1e-18 N-acetyl-D-glucosamine kinase OS=Mus musculus GN=Nagk PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9812 BP_3 111.87 2.20 2747 642921884 XP_967663.2 2711 7.8e-304 PREDICTED: conserved oligomeric Golgi complex subunit 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VJD3 1057 2.0e-113 Conserved oligomeric Golgi complex subunit 5 OS=Drosophila melanogaster GN=fws PE=2 SV=1 PF10392//PF14144 Golgi transport complex subunit 5//Seed dormancy control GO:0006351//GO:0006891 transcription, DNA-templated//intra-Golgi vesicle-mediated transport GO:0043565 sequence-specific DNA binding GO:0017119 Golgi transport complex KOG2211 Predicted Golgi transport complex 1 protein Cluster-8309.9814 BP_3 28.00 0.60 2535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0046813//GO:0061025 receptor-mediated virion attachment to host cell//membrane fusion -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-8309.9815 BP_3 9.00 0.31 1683 303307787 ADM14334.1 2245 5.2e-250 relish [Eriocheir sinensis] 303307786 GQ871279.1 814 0 Eriocheir sinensis relish mRNA, complete cds K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 535 4.1e-53 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.9816 BP_3 4.00 4.90 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9817 BP_3 12.44 0.38 1871 751231572 XP_011169356.1 766 1.8e-78 PREDICTED: uncharacterized protein LOC105202492 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF04218//PF03184 helix-turn-helix, Psq domain//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.9818 BP_3 26.77 0.67 2212 751231572 XP_011169356.1 774 2.6e-79 PREDICTED: uncharacterized protein LOC105202492 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF04218//PF03184 helix-turn-helix, Psq domain//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease -- -- GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.982 BP_3 2.00 1.12 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9824 BP_3 56.79 2.23 1517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9827 BP_3 9.72 0.34 1663 671030805 XP_008706191.1 427 3.3e-39 PREDICTED: zinc finger protein 37 homolog [Ursus maritimus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9Y6Q3 429 8.0e-41 Zinc finger protein 37 homolog OS=Homo sapiens GN=ZFP37 PE=2 SV=3 PF16622//PF05191//PF01428//PF13912//PF02892//PF13465//PF02701//PF01096//PF07776//PF00130//PF00096 zinc-finger C2H2-type//Adenylate kinase, active site lid//AN1-like Zinc finger//C2H2-type zinc finger//BED zinc finger//Zinc-finger double domain//Dof domain, zinc finger//Transcription factor S-II (TFIIS)//Zinc-finger associated domain (zf-AD)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type GO:0006355//GO:0035556//GO:0006351//GO:0046034//GO:0006144 regulation of transcription, DNA-templated//intracellular signal transduction//transcription, DNA-templated//ATP metabolic process//purine nucleobase metabolic process GO:0008270//GO:0003676//GO:0046872//GO:0004017//GO:0003677 zinc ion binding//nucleic acid binding//metal ion binding//adenylate kinase activity//DNA binding GO:0005634 nucleus -- -- Cluster-8309.983 BP_3 27.00 0.78 1956 676450056 XP_009052254.1 146 1.5e-06 hypothetical protein LOTGIDRAFT_174663 [Lottia gigantea]>gi|556108404|gb|ESO97056.1| hypothetical protein LOTGIDRAFT_174663 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9830 BP_3 31.10 0.91 1937 821123351 XP_012384018.1 634 3.8e-63 PREDICTED: zinc finger protein 420-like [Dasypus novemcinctus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 614 3.3e-62 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF00096//PF13465//PF16622//PF07776//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.9831 BP_3 18.95 0.44 2391 667281488 XP_008574444.1 629 1.8e-62 PREDICTED: zinc finger protein 778-like [Galeopterus variegatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96MU6 612 6.9e-62 Zinc finger protein 778 OS=Homo sapiens GN=ZNF778 PE=1 SV=3 PF00096//PF01155//PF03119//PF07649//PF07776//PF13465//PF02892//PF04810//PF13912//PF00751//PF16622 Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//NAD-dependent DNA ligase C4 zinc finger domain//C1-like domain//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//BED zinc finger//Sec23/Sec24 zinc finger//C2H2-type zinc finger//DM DNA binding domain//zinc-finger C2H2-type GO:0055114//GO:0006260//GO:0006355//GO:0006886//GO:0006281//GO:0006464//GO:0006888 oxidation-reduction process//DNA replication//regulation of transcription, DNA-templated//intracellular protein transport//DNA repair//cellular protein modification process//ER to Golgi vesicle-mediated transport GO:0047134//GO:0008270//GO:0043565//GO:0046872//GO:0016151//GO:0003677//GO:0003911 protein-disulfide reductase activity//zinc ion binding//sequence-specific DNA binding//metal ion binding//nickel cation binding//DNA binding//DNA ligase (NAD+) activity GO:0030127//GO:0005634 COPII vesicle coat//nucleus -- -- Cluster-8309.9832 BP_3 22.26 0.94 1431 821123351 XP_012384018.1 634 2.8e-63 PREDICTED: zinc finger protein 420-like [Dasypus novemcinctus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8N184 615 1.9e-62 Zinc finger protein 567 OS=Homo sapiens GN=ZNF567 PE=1 SV=3 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.9833 BP_3 11.87 0.35 1909 821123351 XP_012384018.1 634 3.8e-63 PREDICTED: zinc finger protein 420-like [Dasypus novemcinctus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 614 3.2e-62 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF13465//PF00096//PF13912//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.9838 BP_3 132.68 1.42 4796 642928842 XP_008195585.1 1151 1.1e-122 PREDICTED: uncharacterized protein LOC657427 isoform X1 [Tribolium castaneum] 642928841 XM_008197363.1 271 4.90469e-137 PREDICTED: Tribolium castaneum uncharacterized LOC657427 (LOC657427), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF00951//PF01284 Arterivirus GL envelope glycoprotein//Membrane-associating domain -- -- -- -- GO:0019031//GO:0016020 viral envelope//membrane -- -- Cluster-8309.9845 BP_3 48.47 1.47 1882 768443546 XP_011563593.1 141 5.5e-06 PREDICTED: uncharacterized protein LOC105393516 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.985 BP_3 19.29 0.43 2440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9854 BP_3 1.00 0.72 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9856 BP_3 35.00 2.15 1077 765336429 XP_011493101.1 237 2.3e-17 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- K15503 ANKRD44 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K15503 Q5UPA0 223 4.0e-17 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.9857 BP_3 1.00 2.72 284 780086179 XP_011673431.1 256 3.8e-20 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Strongylocentrotus purpuratus] -- -- -- -- -- K12329 PPP1R12B, MYPT2 protein phosphatase 1 regulatory subunit 12B http://www.genome.jp/dbget-bin/www_bget?ko:K12329 Q4UMH6 225 6.1e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.986 BP_3 11.00 0.57 1224 641653119 XP_008178667.1 843 1.4e-87 PREDICTED: piggyBac transposable element-derived protein 3-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q96JS3 300 5.3e-26 PiggyBac transposable element-derived protein 1 OS=Homo sapiens GN=PGBD1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9864 BP_3 6.00 0.31 1234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9865 BP_3 2384.48 80.86 1713 642925210 XP_008194470.1 1729 3.6e-190 PREDICTED: fatty acyl-CoA reductase 1 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1022 1.4e-109 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01370//PF01073//PF01118//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//Male sterility protein GO:0008210//GO:0008207//GO:0006694//GO:0055114//GO:0008209 estrogen metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process GO:0003854//GO:0050662//GO:0003824//GO:0051287//GO:0016616//GO:0080019//GO:0016620 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG1221 Acyl-CoA reductase Cluster-8309.9879 BP_3 3.00 0.74 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9883 BP_3 44.91 1.28 1983 642924460 XP_008194307.1 1504 5.1e-164 PREDICTED: G2/mitotic-specific cyclin-B3 isoform X1 [Tribolium castaneum]>gi|270006787|gb|EFA03235.1| hypothetical protein TcasGA2_TC013167 [Tribolium castaneum] -- -- -- -- -- K05868 CCNB cyclin B http://www.genome.jp/dbget-bin/www_bget?ko:K05868 Q9I7I0 936 1.5e-99 G2/mitotic-specific cyclin-B3 OS=Drosophila melanogaster GN=CycB3 PE=1 SV=1 PF02984 Cyclin, C-terminal domain GO:0051726 regulation of cell cycle -- -- GO:0005634 nucleus KOG0653 Cyclin B and related kinase-activating proteins Cluster-8309.9887 BP_3 24.00 0.44 2892 642924880 XP_008194081.1 597 1.1e-58 PREDICTED: golgin subfamily B member 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25386 259 7.2e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF04508//PF04111//PF02570 Viral A-type inclusion protein repeat//Autophagy protein Apg6//Precorrin-8X methylmutase GO:0016032//GO:0006914//GO:0015994//GO:0009236 viral process//autophagy//chlorophyll metabolic process//cobalamin biosynthetic process GO:0016993 precorrin-8X methylmutase activity -- -- -- -- Cluster-8309.9897 BP_3 21.89 0.93 1428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9900 BP_3 158.41 3.92 2242 642936652 XP_008198524.1 1161 3.5e-124 PREDICTED: tetratricopeptide repeat protein 17-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96AE7 166 3.4e-10 Tetratricopeptide repeat protein 17 OS=Homo sapiens GN=TTC17 PE=1 SV=1 PF13414//PF13176//PF13374//PF00515//PF13371//PF02207//PF13181//PF02064 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Putative zinc finger in N-recognin (UBR box)//Tetratricopeptide repeat//MAS20 protein import receptor GO:0006605//GO:0006886 protein targeting//intracellular protein transport GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.9902 BP_3 1.00 8.38 248 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9903 BP_3 29.00 0.79 2058 478255618 ENN75831.1 1483 1.5e-161 hypothetical protein YQE_07639, partial [Dendroctonus ponderosae]>gi|546670991|gb|ERL83518.1| hypothetical protein D910_00555 [Dendroctonus ponderosae]>gi|546682737|gb|ERL92639.1| hypothetical protein D910_09952 [Dendroctonus ponderosae] 642916697 XM_001812646.2 242 2.75517e-121 PREDICTED: Tribolium castaneum fork head domain-containing protein crocodile (LOC100142409), mRNA K09396 FOXC forkhead box protein C http://www.genome.jp/dbget-bin/www_bget?ko:K09396 P32027 615 2.7e-62 Fork head domain-containing protein crocodile OS=Drosophila melanogaster GN=croc PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.9904 BP_3 4.79 0.37 911 642923487 XP_008193531.1 290 1.4e-23 PREDICTED: RNA binding protein fox-1 homolog 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K14946 RBFOX, FOX RNA binding protein fox-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14946 Q642J5 226 1.5e-17 RNA binding protein fox-1 homolog 1 OS=Danio rerio GN=rbfox1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.9914 BP_3 3.00 0.33 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9915 BP_3 34.54 0.87 2198 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9916 BP_3 16.24 0.46 1999 91090228 XP_968551.1 525 1.7e-50 PREDICTED: uncharacterized protein LOC656965 [Tribolium castaneum]>gi|270013773|gb|EFA10221.1| hypothetical protein TcasGA2_TC012417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- -- -- Cluster-8309.9919 BP_3 117.31 3.60 1861 282721120 NP_001164234.1 1154 1.9e-123 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 792 7.2e-83 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0020037//GO:0004497//GO:0005506 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//monooxygenase activity//iron ion binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.9925 BP_3 11.00 1.86 576 546678121 ERL88830.1 507 6.0e-49 hypothetical protein D910_06212 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9927 BP_3 11.23 0.31 2050 817072963 XP_012258600.1 180 1.8e-10 PREDICTED: uncharacterized protein LOC105687494 isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9934 BP_3 117.48 6.82 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14604 Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9941 BP_3 29.86 1.21 1483 826407576 XP_012543665.1 570 7.7e-56 PREDICTED: putative nuclease HARBI1 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- Q96MB7 147 3.6e-08 Putative nuclease HARBI1 OS=Homo sapiens GN=HARBI1 PE=1 SV=1 PF04827//PF01609//PF09339//PF02796 Plant transposon protein//Transposase DDE domain//IclR helix-turn-helix domain//Helix-turn-helix domain of resolvase GO:0006355//GO:0006310//GO:0006313 regulation of transcription, DNA-templated//DNA recombination//transposition, DNA-mediated GO:0016788//GO:0003677//GO:0000150//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//recombinase activity//transposase activity -- -- -- -- Cluster-8309.9943 BP_3 96.30 1.70 3028 642939077 XP_008200212.1 837 1.7e-86 PREDICTED: probable WRKY transcription factor protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9946 BP_3 2.02 0.36 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9958 BP_3 9.00 0.44 1288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.996 BP_3 1.00 0.42 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9962 BP_3 13.00 1.22 805 470294583 XP_004344435.1 666 3.1e-67 large subunit ribosomal protein 1 [Capsaspora owczarzaki ATCC 30864]>gi|765555990|gb|KJE96494.1| large subunit ribosomal protein 1 [Capsaspora owczarzaki ATCC 30864] 697079451 XM_009655183.1 783 0 Verticillium dahliae VdLs.17 60S ribosomal protein L10a mRNA K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q7RZS0 905 2.5e-96 60S ribosomal protein L10a OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=crp-74 PE=3 SV=1 PF15180//PF00209 Neuropeptides B and W//Sodium:neurotransmitter symporter family GO:0006812//GO:0007165//GO:0006836 cation transport//signal transduction//neurotransmitter transport GO:0001664//GO:0005328 G-protein coupled receptor binding//neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG1570 60S ribosomal protein L10A Cluster-8309.9967 BP_3 29.06 0.52 2980 478260135 ENN79920.1 156 1.6e-07 hypothetical protein YQE_03739, partial [Dendroctonus ponderosae]>gi|546672547|gb|ERL84367.1| hypothetical protein D910_01792 [Dendroctonus ponderosae]>gi|546678179|gb|ERL88871.1| hypothetical protein D910_06253 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9968 BP_3 2.00 0.32 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9972 BP_3 1.00 0.86 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9977 BP_3 111.01 1.93 3068 642917395 XP_008191178.1 2504 8.8e-280 PREDICTED: DNA ligase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 P51892 2103 1.1e-234 DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1 PF04675//PF04679//PF01068//PF01331 DNA ligase N terminus//ATP dependent DNA ligase C terminal region//ATP dependent DNA ligase domain//mRNA capping enzyme, catalytic domain GO:0006397//GO:0006281//GO:0006310//GO:0006370//GO:0006260 mRNA processing//DNA repair//DNA recombination//7-methylguanosine mRNA capping//DNA replication GO:0005524//GO:0003677//GO:0004484//GO:0003910 ATP binding//DNA binding//mRNA guanylyltransferase activity//DNA ligase (ATP) activity -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.9978 BP_3 31.00 1.00 1788 817061123 XP_012252151.1 308 2.2e-25 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07728//PF00580//PF00448 AAA domain (dynein-related subfamily)//UvrD/REP helicase N-terminal domain//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0005524//GO:0016887 GTP binding//ATP binding//ATPase activity -- -- -- -- Cluster-8309.9979 BP_3 195.00 2.22 4531 390362249 XP_001190749.2 1897 3.2e-209 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- P16157 1019 8.4e-109 Ankyrin-1 OS=Homo sapiens GN=ANK1 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.998 BP_3 10.00 0.69 990 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9989 BP_3 4.00 0.50 676 646703157 KDR11973.1 190 4.1e-12 Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 [Zootermopsis nevadensis] -- -- -- -- -- K11420 EHMT euchromatic histone-lysine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9996 BP_3 18.48 0.31 3136 91087247 XP_975518.1 448 2.3e-41 PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929756|ref|XP_008195961.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929758|ref|XP_008195962.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929760|ref|XP_008195963.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 -- -- -- -- PF07690//PF03137//PF06800//PF00083 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Sugar transport protein//Sugar (and other) transporter GO:0034219//GO:0008643//GO:0006810//GO:0055085 carbohydrate transmembrane transport//carbohydrate transport//transport//transmembrane transport GO:0005215//GO:0015144//GO:0022857 transporter activity//carbohydrate transmembrane transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.9997 BP_3 5.00 0.72 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9998 BP_3 5.88 0.42 973 332376709 AEE63494.1 836 7.2e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q9NWM0 312 1.7e-27 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0029 Amine oxidase Cluster-8309.9999 BP_3 10.61 3.82 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-832.0 BP_3 3.00 0.46 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8320.0 BP_3 1.00 0.35 429 -- -- -- -- -- 333031574 HM068057.1 83 1.31745e-33 Oryctes rhinoceros clone OrBP10M-9 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8341.0 BP_3 3.00 0.43 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8356.1 BP_3 4.00 0.46 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8358.0 BP_3 1.00 0.32 443 328697481 XP_003240351.1 193 1.2e-12 PREDICTED: uncharacterized protein LOC100573963 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8364.0 BP_3 7.00 3.97 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8365.0 BP_3 1.00 0.33 439 768042049 XP_011544570.1 241 3.2e-18 PREDICTED: histone-lysine N-methyltransferase 2C-like [Homo sapiens] 308818305 AC242799.1 433 0 Homo sapiens BAC clone CH17-28J16 from chromosome 1, complete sequence K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8BRH4 220 3.6e-17 Histone-lysine N-methyltransferase 2C OS=Mus musculus GN=Kmt2c PE=1 SV=2 PF00130//PF13639//PF16866//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Ring finger domain//PHD-finger//PHD-finger GO:0035556 intracellular signal transduction GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8375.0 BP_3 2.00 0.92 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8376.0 BP_3 16.00 0.80 1254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-838.0 BP_3 1.00 0.59 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-839.0 BP_3 2.00 0.50 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8393.0 BP_3 5.00 0.58 704 861611643 KMQ85334.1 172 5.2e-10 hypothetical protein RF55_16186, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8402.0 BP_3 3.00 0.36 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8421.2 BP_3 1.00 0.45 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8421.3 BP_3 15.00 0.39 2157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8421.4 BP_3 4.00 1.01 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8422.0 BP_3 6.00 0.35 1110 642933635 XP_008197504.1 381 4.8e-34 PREDICTED: uncharacterized protein LOC100142237 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8432.0 BP_3 4.19 9.32 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8433.0 BP_3 2.00 0.32 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8435.0 BP_3 2.00 0.37 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8439.0 BP_3 1.00 0.96 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8450.0 BP_3 2.00 0.98 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8451.0 BP_3 11.61 0.76 1032 668454899 KFB43280.1 377 1.3e-33 AGAP005526-PA-like protein [Anopheles sinensis] -- -- -- -- -- K14616 CUBN cubilin http://www.genome.jp/dbget-bin/www_bget?ko:K14616 O60494 243 1.8e-19 Cubilin OS=Homo sapiens GN=CUBN PE=1 SV=5 -- -- -- -- -- -- -- -- -- -- Cluster-8467.0 BP_3 9.00 1.86 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8473.0 BP_3 2.00 0.42 521 269316054 XP_641372.4 489 6.7e-47 NAD+ dependent glutamate dehydrogenase [Dictyostelium discoideum AX4]>gi|263432342|sp|Q54VI3.2|GLUD2_DICDI RecName: Full=Glutamate dehydrogenase 2; AltName: Full=NAD-specific glutamate dehydrogenase; Short=NAD-GDH>gi|165988616|gb|EAL67386.2| NAD+ dependent glutamate dehydrogenase [Dictyostelium discoideum AX4] 768311755 CP010983.1 515 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- P00365 710 6.5e-74 NAD-specific glutamate dehydrogenase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gdh-1 PE=1 SV=4 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8478.0 BP_3 3.00 0.33 734 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8480.0 BP_3 2.00 0.45 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8490.0 BP_3 2.00 0.45 506 826419936 XP_012524876.1 306 1.1e-25 PREDICTED: uncharacterized protein LOC105830222 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8490.1 BP_3 3.00 0.55 554 641681761 XP_008189587.1 256 7.4e-20 PREDICTED: uncharacterized protein LOC103311674 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8497.0 BP_3 4.00 0.31 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8499.0 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-85.0 BP_3 6.08 2.25 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8506.0 BP_3 2.00 0.86 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8510.0 BP_3 2.00 0.44 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8512.0 BP_3 4.00 0.95 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8519.0 BP_3 2.00 0.90 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8523.0 BP_3 2.00 0.64 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8532.1 BP_3 5.00 0.67 653 675859680 XP_009015400.1 444 1.4e-41 hypothetical protein HELRODRAFT_160147 [Helobdella robusta]>gi|675876278|ref|XP_009023699.1| hypothetical protein HELRODRAFT_184410 [Helobdella robusta]>gi|555694970|gb|ESN98202.1| hypothetical protein HELRODRAFT_184410 [Helobdella robusta]>gi|555702799|gb|ESO06032.1| hypothetical protein HELRODRAFT_160147 [Helobdella robusta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8533.1 BP_3 11.00 0.87 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8536.0 BP_3 4.32 0.34 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8561.0 BP_3 1.00 2.17 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8564.0 BP_3 3.00 0.49 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8565.0 BP_3 15.00 1.42 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8566.0 BP_3 7.00 0.34 1282 817077763 XP_012261226.1 272 2.4e-21 PREDICTED: putative ammonium transporter 1 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00909 Ammonium Transporter Family GO:0015696 ammonium transport GO:0008519 ammonium transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8574.0 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8579.0 BP_3 12.00 0.54 1357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8587.0 BP_3 6.00 2.33 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-86.0 BP_3 79.00 6.76 855 91090836 XP_972093.1 416 3.2e-38 PREDICTED: uncharacterized protein LOC660796 [Tribolium castaneum]>gi|270013989|gb|EFA10437.1| hypothetical protein TcasGA2_TC012680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8614.0 BP_3 3.00 1.16 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8619.0 BP_3 2.00 0.48 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8620.0 BP_3 6.00 0.73 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8629.0 BP_3 1.00 0.33 439 307208243 EFN85686.1 231 4.7e-17 hypothetical protein EAI_09677, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00292 'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8635.1 BP_3 2.00 0.48 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8636.0 BP_3 4.00 0.44 733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8647.0 BP_3 2.00 0.34 578 815769669 XP_012234959.1 383 1.5e-34 PREDICTED: uncharacterized protein LOC105679478 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8653.0 BP_3 4.00 0.76 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8656.0 BP_3 3.00 0.88 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8662.0 BP_3 1.00 0.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8670.0 BP_3 3.00 0.56 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8675.0 BP_3 3.00 0.45 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8678.0 BP_3 2.00 0.33 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-868.0 BP_3 2.00 0.36 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8696.0 BP_3 3.00 0.46 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8698.1 BP_3 20.00 0.40 2721 642914085 XP_008201538.1 1486 8.6e-162 PREDICTED: pituitary homeobox homolog Ptx1 isoform X2 [Tribolium castaneum] 642914084 XM_008203316.1 512 0 PREDICTED: Tribolium castaneum pituitary homeobox (LOC658711), transcript variant X2, mRNA K04686 PITX2 paired-like homeodomain transcription factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04686 O18400 815 2.3e-85 Pituitary homeobox homolog Ptx1 OS=Drosophila melanogaster GN=Ptx1 PE=2 SV=2 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0486 Transcription factor PTX1, contains HOX domain Cluster-8699.0 BP_3 13.00 0.72 1168 672033601 XP_008756483.1 246 2.3e-18 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 431-like isoform X1, partial [Rattus norvegicus] -- -- -- -- -- K09195 SP5 transcription factor Sp5 http://www.genome.jp/dbget-bin/www_bget?ko:K09195 Q9JHX2 510 2.3e-50 Transcription factor Sp5 OS=Mus musculus GN=Sp5 PE=2 SV=1 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-870.0 BP_3 8.00 0.68 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8705.0 BP_3 1.00 0.39 413 642928535 XP_008195364.1 374 1.1e-33 PREDICTED: uncharacterized protein LOC103313570 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8705.1 BP_3 5.00 0.39 913 270010346 EFA06794.1 852 9.5e-89 hypothetical protein TcasGA2_TC009732 [Tribolium castaneum] 462338969 APGK01036978.1 55 1.074e-17 Dendroctonus ponderosae Seq01036988, whole genome shotgun sequence -- -- -- -- B0BM24 214 3.7e-16 Protein FAM161A OS=Xenopus tropicalis GN=fam161a PE=2 SV=1 PF16326 ABC transporter C-terminal domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8708.1 BP_3 1.00 0.61 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8715.0 BP_3 2.00 0.41 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8720.0 BP_3 3.00 0.32 738 657596884 XP_008303166.1 524 8.3e-51 PREDICTED: adenylyl cyclase-associated protein 1 [Stegastes partitus] -- -- -- -- -- K17261 CAP1_2, SRV2 adenylyl cyclase-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17261 Q01518 461 6.9e-45 Adenylyl cyclase-associated protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=5 PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8720.1 BP_3 11.00 0.46 1435 45361313 NP_989234.1 1032 2.0e-109 uncharacterized protein LOC394843 [Xenopus (Silurana) tropicalis]>gi|38969870|gb|AAH63367.1| hypothetical protein MGC75973 [Xenopus (Silurana) tropicalis] 308322532 GU588448.1 104 9.8641e-45 Ictalurus furcatus clone CBZF8503 mitochondrial cytochrome c1 heme protein (CY1) mRNA, complete cds; nuclear gene for mitochondrial product K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 967 2.8e-103 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF13442//PF02167//PF00034 Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome C1 family//Cytochrome c GO:0006118 obsolete electron transport GO:0020037//GO:0005488//GO:0009055 heme binding//binding//electron carrier activity -- -- KOG3052 Cytochrome c1 Cluster-8723.0 BP_3 1.00 0.34 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09803 Uncharacterized conserved protein (DUF2346) GO:0033617 mitochondrial respiratory chain complex IV assembly -- -- GO:0005739 mitochondrion -- -- Cluster-8724.0 BP_3 2.00 0.34 574 260796537 XP_002593261.1 489 7.3e-47 hypothetical protein BRAFLDRAFT_87242 [Branchiostoma floridae]>gi|229278485|gb|EEN49272.1| hypothetical protein BRAFLDRAFT_87242 [Branchiostoma floridae] -- -- -- -- -- K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P32122 445 3.8e-43 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 PF00629 MAM domain, meprin/A5/mu GO:0007165 signal transduction -- -- GO:0016020 membrane KOG3865 Arrestin Cluster-8729.0 BP_3 1.00 1.37 314 699667905 XP_009883999.1 220 6.3e-16 PREDICTED: uncharacterized protein LOC104287046, partial [Charadrius vociferus] 42794112 AC137993.2 311 1.68361e-160 Oryza sativa Japonica Group chromosome 11 clone OSJNBb0122P24, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8745.0 BP_3 4.00 0.47 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-875.0 BP_3 5.00 1.72 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8759.1 BP_3 2.00 0.33 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8760.0 BP_3 4.00 0.89 508 642932874 XP_008197021.1 411 7.2e-38 PREDICTED: protein vav-1-like [Tribolium castaneum]>gi|270011507|gb|EFA07955.1| hypothetical protein TcasGA2_TC005536 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8762.0 BP_3 2.00 0.51 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8768.0 BP_3 3.00 0.41 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8769.0 BP_3 2.00 0.78 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8775.0 BP_3 2.00 0.39 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8779.0 BP_3 3.00 1.03 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8789.0 BP_3 3.00 0.74 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8790.0 BP_3 62.00 1.48 2312 642939601 XP_008194551.1 474 1.6e-44 PREDICTED: uncharacterized protein LOC103313314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8794.0 BP_3 2.00 0.34 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8806.0 BP_3 1.00 0.41 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8812.0 BP_3 2.00 0.47 496 861619004 KMQ86923.1 447 4.7e-42 mariner transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8815.0 BP_3 3.00 0.32 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8818.0 BP_3 1.00 3.21 278 -- -- -- -- -- 780682006 XM_011699452.1 46 3.01572e-13 PREDICTED: Wasmannia auropunctata putative uncharacterized protein FLJ37770 (LOC105455825), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8820.0 BP_3 43.00 1.00 2355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8833.0 BP_3 3.00 0.38 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8839.1 BP_3 2.00 0.40 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8843.0 BP_3 1.00 0.95 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8850.0 BP_3 1.00 0.46 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8871.0 BP_3 1.00 1.03 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8897.0 BP_3 3.38 0.31 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-89.0 BP_3 7.00 1.18 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-890.0 BP_3 2.00 0.75 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8901.0 BP_3 1.00 0.37 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00961 LAGLIDADG endonuclease -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-8921.0 BP_3 3.00 1.11 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8960.0 BP_3 2.00 0.46 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8961.0 BP_3 4.00 0.80 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8961.3 BP_3 1.00 0.49 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8967.1 BP_3 28.30 2.17 920 768445539 XP_011564676.1 421 9.1e-39 PREDICTED: hrp65 protein-like isoform X1 [Plutella xylostella] -- -- -- -- -- K13219 SFPQ, PSF splicing factor, proline- and glutamine-rich http://www.genome.jp/dbget-bin/www_bget?ko:K13219 Q9U1N0 414 2.4e-39 Hrp65 protein OS=Chironomus tentans GN=HRP65 PE=1 SV=1 PF00076//PF02601 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0003676//GO:0008855 nucleic acid binding//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG0115 RNA-binding protein p54nrb (RRM superfamily) Cluster-8978.0 BP_3 2.00 0.41 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8980.0 BP_3 2.00 0.35 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8995.0 BP_3 3.00 0.51 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9.0 BP_3 22.00 1.94 839 321473145 EFX84113.1 167 2.3e-09 hypothetical protein DAPPUDRAFT_315291 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-90.0 BP_3 12.00 5.14 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9006.0 BP_3 3.00 0.64 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9008.0 BP_3 2.00 0.41 526 759123247 XP_011359588.1 149 1.8e-07 PREDICTED: tenascin-N [Pteropus vampyrus] -- -- -- -- -- -- -- -- -- Q80Z71 135 3.1e-07 Tenascin-N OS=Mus musculus GN=Tnn PE=1 SV=2 PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-9023.0 BP_3 1.00 0.61 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9032.0 BP_3 1.00 0.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9033.0 BP_3 3.00 0.50 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9036.0 BP_3 18.99 0.60 1825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9042.0 BP_3 8.26 0.68 875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03014 Structural protein 2 -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-9043.0 BP_3 1.00 0.31 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9048.0 BP_3 2.00 0.61 449 239949541 ACS36545.1 476 1.9e-45 troponin C isoform 5 [Homarus americanus] 239949540 FJ790224.1 129 3.71426e-59 Homarus americanus troponin C isoform 5 mRNA, complete cds -- -- -- -- P15159 223 1.7e-17 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF13499//PF13833//PF13405//PF00036//PF12763//PF13202 EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-9055.0 BP_3 2.00 0.31 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9058.0 BP_3 2.00 0.46 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9073.1 BP_3 1.00 0.31 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9080.0 BP_3 4.00 0.58 624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9089.0 BP_3 3.00 0.32 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-91.0 BP_3 5.00 1.75 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9112.0 BP_3 2.00 0.45 504 607352346 EZA47325.1 300 5.3e-25 hypothetical protein X777_16415, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9113.0 BP_3 4.00 0.42 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9115.0 BP_3 4.00 0.34 866 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9123.0 BP_3 4.00 0.44 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9125.0 BP_3 7.00 0.48 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9130.0 BP_3 5.00 0.41 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9133.0 BP_3 13.00 0.93 966 546673130 ERL84795.1 674 4.4e-68 hypothetical protein D910_02220 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13508//PF00583//PF01233//PF08445 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0004379//GO:0016747//GO:0008080 glycylpeptide N-tetradecanoyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- -- -- Cluster-9134.0 BP_3 2.00 1.19 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9143.0 BP_3 2.00 0.64 443 665791522 XP_008543320.1 609 6.9e-61 PREDICTED: signal recognition particle receptor subunit alpha homolog [Microplitis demolitor] 704282008 XM_010158548.1 69 8.26759e-26 PREDICTED: Eurypyga helias signal recognition particle receptor (docking protein) (SRPR), partial mRNA K13431 SRPR signal recognition particle receptor subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13431 Q9U5L1 567 2.1e-57 Signal recognition particle receptor subunit alpha homolog OS=Drosophila melanogaster GN=Gtp-bp PE=1 SV=2 PF00448//PF06309//PF02881//PF00931 SRP54-type protein, GTPase domain//Torsin//SRP54-type protein, helical bundle domain//NB-ARC domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0043531//GO:0005524//GO:0005525 ADP binding//ATP binding//GTP binding -- -- KOG0781 Signal recognition particle receptor, alpha subunit Cluster-9144.0 BP_3 2.00 0.40 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9145.0 BP_3 2.00 0.80 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9153.0 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9159.0 BP_3 7.00 0.47 1003 301500958 YP_003795423.1 890 4.1e-93 photosystem I P700 chlorophyll a apoprotein A2 [Alveolata sp. CCMP3155]>gi|300069504|gb|ADJ66611.1| photosystem I P700 chlorophyll a apoprotein A2 (chloroplast) [Chromerida sp. RM11] 808178593 KP760075.1 928 0 Prunus subhirtella var. subhirtella isolate 2014-P2 chloroplast, complete genome -- -- -- -- Q68S07 1336 3.2e-146 Photosystem I P700 chlorophyll a apoprotein A2 OS=Panax ginseng GN=psaB PE=3 SV=1 PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0009579//GO:0009522//GO:0016021//GO:0044424 thylakoid//photosystem I//integral component of membrane//intracellular part -- -- Cluster-9184.0 BP_3 2.00 0.46 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9185.0 BP_3 40.00 1.04 2141 478263126 ENN81519.1 1220 4.7e-131 hypothetical protein YQE_02048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00163//PF00379 Ribosomal protein S4/S9 N-terminal domain//Insect cuticle protein -- -- GO:0042302//GO:0019843 structural constituent of cuticle//rRNA binding GO:0005622 intracellular -- -- Cluster-9193.0 BP_3 2.00 0.39 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9198.0 BP_3 3.00 0.70 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9202.0 BP_3 2.00 0.53 473 861625939 KMQ88673.1 166 1.7e-09 histone-lysine n-methyltransferase setmar [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9212.0 BP_3 7.00 0.62 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08943 CsiD -- -- GO:0005506 iron ion binding -- -- -- -- Cluster-9223.0 BP_3 7.00 0.34 1286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9228.0 BP_3 2.51 0.81 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9246.0 BP_3 3.45 0.39 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9249.0 BP_3 21.28 0.72 1715 546682026 ERL92022.1 1123 6.7e-120 hypothetical protein D910_09344, partial [Dendroctonus ponderosae] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46107 683 2.9e-70 Lipase 1 OS=Drosophila melanogaster GN=Lip1 PE=2 SV=2 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-9251.0 BP_3 5.00 0.70 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04799 fzo-like conserved region GO:0008053 mitochondrial fusion GO:0003924 GTPase activity GO:0016021//GO:0005741 integral component of membrane//mitochondrial outer membrane -- -- Cluster-9262.2 BP_3 25.87 0.49 2830 478263132 ENN81525.1 552 1.8e-53 hypothetical protein YQE_02054, partial [Dendroctonus ponderosae]>gi|546681765|gb|ERL91791.1| hypothetical protein D910_09116, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q32PN7 175 3.9e-11 Zinc finger protein DZIP1L OS=Danio rerio GN=dzip1l PE=2 SV=1 PF06689//PF00096//PF13465//PF13912 ClpX C4-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0008270//GO:0046872//GO:0046983 zinc ion binding//metal ion binding//protein dimerization activity -- -- -- -- Cluster-9264.0 BP_3 4.00 0.55 643 -- -- -- -- -- 17975438 AC079305.6 640 0 Homo sapiens BAC clone RP11-483K11 from 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9267.0 BP_3 6.30 0.31 1280 861622185 KMQ87689.1 495 3.3e-47 transposable element tcb1 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- P03934 135 7.6e-07 Transposable element Tc1 transposase OS=Caenorhabditis elegans GN=tc1a PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9274.0 BP_3 7.00 0.51 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02272//PF01607 DHHA1 domain//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061//GO:0003676 chitin binding//nucleic acid binding GO:0005576 extracellular region -- -- Cluster-928.0 BP_3 4.00 0.45 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9290.0 BP_3 21.00 1.17 1160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03357 Snf7 GO:0007034 vacuolar transport -- -- -- -- -- -- Cluster-9291.0 BP_3 1.00 0.34 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01821 Anaphylotoxin-like domain -- -- -- -- GO:0005576 extracellular region -- -- Cluster-9294.0 BP_3 6.00 0.36 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9294.1 BP_3 1.00 1.03 330 646701284 KDR11089.1 194 6.9e-13 Calsyntenin-1 [Zootermopsis nevadensis] 859859937 XM_004766623.2 39 2.84616e-09 PREDICTED: Mustela putorius furo calsyntenin 3 (CLSTN3), mRNA -- -- -- -- -- -- -- -- PF04159 NB glycoprotein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-9294.2 BP_3 2.00 1.02 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9302.0 BP_3 1.00 0.46 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9306.0 BP_3 4.00 0.33 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9309.0 BP_3 31.03 0.70 2443 546677105 ERL88006.1 884 5.0e-92 hypothetical protein D910_05395 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZUX3 313 3.3e-27 Protein FAM179A OS=Homo sapiens GN=FAM179A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2933 Uncharacterized conserved protein Cluster-9325.0 BP_3 3.00 0.57 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9332.0 BP_3 14.00 2.11 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9341.0 BP_3 14.00 1.34 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9342.0 BP_3 4.00 0.41 759 -- -- -- -- -- 302414063 XM_003004818.1 560 0 Verticillium albo-atrum VaMs.102 hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF04505 Interferon-induced transmembrane protein GO:0009607 response to biotic stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-9344.0 BP_3 16.00 0.38 2303 270008212 EFA04660.1 1809 2.6e-199 wingless [Tribolium castaneum] 642922428 XM_008194940.1 370 0 PREDICTED: Tribolium castaneum wingless (Wg), transcript variant X1, mRNA K03209 WNT1 wingless-type MMTV integration site family, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03209 P49340 1412 1.1e-154 Protein Wnt-1 OS=Bombyx mori GN=WNT-1 PE=2 SV=1 PF00110 wnt family GO:0007165//GO:0007275//GO:0016055 signal transduction//multicellular organismal development//Wnt signaling pathway GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-9347.0 BP_3 9.00 0.35 1524 270005702 EFA02150.1 1576 1.8e-172 hypothetical protein TcasGA2_TC007802 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TF66 267 4.5e-22 Leucine-rich repeat-containing protein 15 OS=Homo sapiens GN=LRRC15 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-9353.0 BP_3 7.00 0.54 914 -- -- -- -- -- 768311759 CP010987.1 865 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9356.0 BP_3 4.00 0.31 915 215274047 ACJ64921.1 1136 1.1e-121 nicotinic acetylcholine receptor alpha 2 [Leptinotarsa decemlineata] 752868800 XM_011253184.1 104 6.20929e-45 PREDICTED: Camponotus floridanus acetylcholine receptor subunit alpha-L1 (LOC105248417), transcript variant X3, mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P17644 858 7.9e-91 Acetylcholine receptor subunit alpha-like 2 OS=Drosophila melanogaster GN=nAChRalpha2 PE=2 SV=1 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-9367.0 BP_3 1.00 0.36 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9371.1 BP_3 1.00 0.36 423 308051574 ADO00265.1 270 1.3e-21 SIFamide [Cancer borealis] 308051573 GU016327.1 238 8.89359e-120 Cancer borealis SIFamide mRNA, complete cds -- -- -- -- Q867W1 217 7.7e-17 FMRFamide-related neuropeptides OS=Procambarus clarkii PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9371.3 BP_3 2.00 1.15 373 -- -- -- -- -- 299800932 GU327660.1 80 5.26269e-32 Portunus trituberculatus microsatellite Ptri_10 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9372.0 BP_3 3.00 0.48 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9375.0 BP_3 3.00 0.36 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9388.0 BP_3 2.00 0.33 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9389.0 BP_3 3.00 0.52 570 576692949 EUB56577.1 178 8.4e-11 Exostosin-like 3 [Echinococcus granulosus] 768311755 CP010983.1 570 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q5IGR6 166 8.6e-11 Exostosin-1c OS=Danio rerio GN=ext1c PE=2 SV=1 PF09258 Glycosyl transferase family 64 domain GO:0015012//GO:0006024 heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process -- -- GO:0016021 integral component of membrane KOG1022 Acetylglucosaminyltransferase EXT2/exostosin 2 Cluster-9394.0 BP_3 5.00 0.44 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9404.0 BP_3 12.00 0.49 1469 752880987 XP_011258078.1 601 1.9e-59 PREDICTED: lipase 3-like [Camponotus floridanus]>gi|307178434|gb|EFN67149.1| Lipase 3 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q8K2A6 439 4.9e-42 Lipase member M OS=Mus musculus GN=Lipm PE=2 SV=1 PF04083//PF01738 Partial alpha/beta-hydrolase lipase region//Dienelactone hydrolase family GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-9406.0 BP_3 3.00 0.33 732 262401321 ACY66563.1 401 1.5e-36 hypothetical protein [Scylla paramamosain] 262401320 FJ774842.1 414 0 Scylla paramamosain hypothetical protein mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9410.0 BP_3 6.00 0.64 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9411.0 BP_3 1.00 0.55 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9415.0 BP_3 3.00 0.35 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9416.0 BP_3 10.00 0.43 1417 815813926 XP_012227970.1 1737 3.5e-191 PREDICTED: glycogen synthase kinase-3 beta-like isoform X2 [Linepithema humile] 884983992 XM_010905179.2 312 2.30078e-160 PREDICTED: Esox lucius glycogen synthase kinase-3 beta (LOC105031009), transcript variant X4, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P18431 1674 2.9e-185 Protein kinase shaggy OS=Drosophila melanogaster GN=sgg PE=1 SV=3 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0658 Glycogen synthase kinase-3 Cluster-9417.0 BP_3 6.00 0.85 633 156369496 XP_001628012.1 238 1.0e-17 predicted protein [Nematostella vectensis]>gi|156214977|gb|EDO35949.1| predicted protein [Nematostella vectensis] 697079458 XM_009655186.1 571 0 Verticillium dahliae VdLs.17 60S ribosomal protein L39 partial mRNA K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 Q6BHV8 244 8.6e-20 60S ribosomal protein L39 OS=Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) GN=RPL39 PE=3 SV=1 PF00832 Ribosomal L39 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0002 60s ribosomal protein L39 Cluster-9418.0 BP_3 4.00 0.67 581 300678088 ADK27312.1 218 2.0e-15 C-type lectin [Procambarus clarkii] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9422.0 BP_3 7.00 1.17 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00947 Picornavirus core protein 2A GO:0016032//GO:0006508 viral process//proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-9423.0 BP_3 4.00 0.45 722 27370586 AAH37554.1 442 2.6e-41 THRAP3 protein, partial [Homo sapiens] 41350840 BC065519.1 722 0 Homo sapiens thyroid hormone receptor associated protein 3, mRNA (cDNA clone IMAGE:5787102), partial cds K13112 THRAP3 thyroid hormone receptor-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13112 Q9Y2W1 438 3.1e-42 Thyroid hormone receptor-associated protein 3 OS=Homo sapiens GN=THRAP3 PE=1 SV=2 PF02535//PF01080 ZIP Zinc transporter//Presenilin GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0004190//GO:0046873 aspartic-type endopeptidase activity//metal ion transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-9424.1 BP_3 16.24 0.73 1366 765826420 NP_001292289.1 569 9.3e-56 alternative oxidase, mitochondrial-like [Crassostrea gigas]>gi|219664359|gb|ACL31211.1| alternative oxidase [Crassostrea gigas] 697084893 XM_009657074.1 1065 0 Verticillium dahliae VdLs.17 alternative oxidase partial mRNA -- -- -- -- Q9C206 1392 1.4e-152 Alternative oxidase, mitochondrial OS=Podospora anserina GN=AOX1 PE=3 SV=1 PF01786 Alternative oxidase GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009916 alternative oxidase activity -- -- -- -- Cluster-9428.0 BP_3 1.00 0.38 419 675385067 KFM77964.1 372 2.0e-33 Dual specificity protein phosphatase 8, partial [Stegodyphus mimosarum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9BY84 317 1.9e-28 Dual specificity protein phosphatase 16 OS=Homo sapiens GN=DUSP16 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1716 Dual specificity phosphatase Cluster-9431.0 BP_3 2.00 0.51 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9438.0 BP_3 6.00 0.48 892 646716640 KDR19797.1 265 1.1e-20 Alpha-endosulfine, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6GQG3 208 1.8e-15 cAMP-regulated phosphoprotein 19-B OS=Xenopus laevis GN=arpp19-b PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9446.0 BP_3 2.00 0.39 539 588294489 AHK23026.1 390 2.1e-35 beta-1,3-glucan-binding protein precursor [Astacus astacus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9463.0 BP_3 2.00 0.44 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9465.0 BP_3 3.00 0.43 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01269 Fibrillarin GO:0008033//GO:0006364 tRNA processing//rRNA processing GO:0008168//GO:0003723 methyltransferase activity//RNA binding -- -- -- -- Cluster-9467.0 BP_3 2.00 0.33 582 675390066 KFM82963.1 669 1.0e-67 60S ribosomal protein L12, partial [Stegodyphus mimosarum] -- -- -- -- -- K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61865 652 3.9e-67 60S ribosomal protein L12 OS=Caenorhabditis briggsae GN=rpl-12 PE=3 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-9468.0 BP_3 2.00 0.65 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P79017 442 6.5e-43 Major allergen Asp f 2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=AFUA_4G09580 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-9477.0 BP_3 8.00 0.74 812 397522646 XP_003831370.1 1128 8.4e-121 PREDICTED: 60S ribosomal protein L7 isoform X1 [Pan paniscus]>gi|119607405|gb|EAW86999.1| ribosomal protein L7, isoform CRA_a [Homo sapiens]>gi|119607406|gb|EAW87000.1| ribosomal protein L7, isoform CRA_a [Homo sapiens] 426359903 XM_004047148.1 743 0 PREDICTED: Gorilla gorilla gorilla ribosomal protein L7, transcript variant 1 (RPL7), mRNA K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 Q5R9R4 1123 1.3e-121 60S ribosomal protein L7 OS=Pongo abelii GN=RPL7 PE=2 SV=1 -- -- GO:0000184//GO:0006414//GO:0006614//GO:0019083//GO:0042254//GO:0042273//GO:0006415//GO:0006413//GO:0006364 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//translational elongation//SRP-dependent cotranslational protein targeting to membrane//viral transcription//ribosome biogenesis//ribosomal large subunit biogenesis//translational termination//translational initiation//rRNA processing GO:0003677//GO:0003729//GO:0042803//GO:0003735 DNA binding//mRNA binding//protein homodimerization activity//structural constituent of ribosome GO:0022625//GO:0005840 cytosolic large ribosomal subunit//ribosome -- -- Cluster-9491.0 BP_3 3.00 0.38 669 -- -- -- -- -- 697090482 XM_009659852.1 586 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-950.0 BP_3 1.00 0.53 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9500.0 BP_3 7.74 0.31 1515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9515.0 BP_3 1.00 1.76 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9522.0 BP_3 3.00 1.03 432 89258153 ABD65299.1 175 1.4e-10 ENSANGP00000021035-like [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-9526.0 BP_3 6.00 0.41 1001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-9540.0 BP_3 14.00 0.39 2039 823393760 XP_012411586.1 158 6.3e-08 PREDICTED: zinc finger protein 208-like [Trichechus manatus latirostris] 768311759 CP010987.1 1343 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence K06230 GLI3 zinc finger protein GLI3 http://www.genome.jp/dbget-bin/www_bget?ko:K06230 Q873X0 1451 3.0e-159 pH-response transcription factor pacC/RIM101 OS=Gibberella moniliformis GN=PAC1 PE=3 SV=1 PF13912//PF00096//PF02176//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-9540.1 BP_3 29.00 0.46 3313 281210383 EFA84549.1 1200 1.5e-128 P-type ATPase [Polysphondylium pallidum PN500] 302418133 XM_003006852.1 2839 0 Verticillium albo-atrum VaMs.102 plasma membrane ATPase, mRNA -- -- -- -- P07038 3614 0.0e+00 Plasma membrane ATPase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=pma-1 PE=1 SV=1 PF15234//PF00122 Linker for activation of T-cells//E1-E2 ATPase GO:0007165 signal transduction GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0016020 membrane KOG0205 Plasma membrane H+-transporting ATPase Cluster-9541.1 BP_3 4.00 0.58 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9541.2 BP_3 3.00 0.34 711 270015858 EFA12306.1 233 4.4e-17 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9542.0 BP_3 6.85 0.34 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9553.0 BP_3 6.00 0.48 900 299930735 ADJ58583.1 210 2.6e-14 seminal fluid protein HACP049 [Heliconius melpomene] -- -- -- -- -- -- -- -- -- Q7Z410 168 7.9e-11 Transmembrane protease serine 9 OS=Homo sapiens GN=TMPRSS9 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-9554.0 BP_3 2.00 0.48 493 815897704 XP_012249582.1 391 1.5e-35 PREDICTED: eukaryotic translation initiation factor 4 gamma 3-like isoform X3 [Bombus impatiens] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 O43432 335 1.9e-30 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens GN=EIF4G3 PE=1 SV=2 PF02854 MIF4G domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-9558.0 BP_3 2.00 0.59 456 321472546 EFX83516.1 480 6.5e-46 ABC protein, subfamily ABCG [Daphnia pulex] -- -- -- -- -- -- -- -- -- P10090 431 1.3e-41 Protein white OS=Drosophila melanogaster GN=w PE=2 SV=2 PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-9564.0 BP_3 1.00 0.32 441 749731022 XP_011149266.1 357 1.2e-31 PREDICTED: M-phase inducer phosphatase-like isoform X1 [Harpegnathos saltator] -- -- -- -- -- K16723 STG M-phase inducer phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16723 P20483 300 1.9e-26 M-phase inducer phosphatase OS=Drosophila melanogaster GN=stg PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3772 M-phase inducer phosphatase Cluster-9567.0 BP_3 16.19 0.36 2437 642915103 XP_008190411.1 610 2.9e-60 PREDICTED: uncharacterized protein LOC103312184 isoform X1 [Tribolium castaneum]>gi|642915107|ref|XP_008190412.1| PREDICTED: uncharacterized protein LOC103312184 isoform X1 [Tribolium castaneum] 462418379 APGK01017096.1 69 4.84056e-25 Dendroctonus ponderosae Seq01017106, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF15216 Thymic stromal lymphopoietin GO:0007165 signal transduction GO:0005125 cytokine activity -- -- -- -- Cluster-9572.0 BP_3 3.00 0.32 744 91080431 XP_968599.1 147 4.3e-07 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9577.0 BP_3 4.00 0.43 740 318111902 NP_001188014.1 607 2.0e-60 mitochondrial putative octanoyltransferase [Ictalurus punctatus]>gi|308324593|gb|ADO29431.1| mitochondrial putative octanoyltransferase [Ictalurus punctatus] -- -- -- -- -- K03801 lipB lipoyl(octanoyl) transferase http://www.genome.jp/dbget-bin/www_bget?ko:K03801 Q29R99 567 3.5e-57 Putative lipoyltransferase 2, mitochondrial OS=Danio rerio GN=lipt2 PE=2 SV=1 PF03099 Biotin/lipoate A/B protein ligase family GO:0044238//GO:0044237//GO:0006464//GO:0071704 primary metabolic process//cellular metabolic process//cellular protein modification process//organic substance metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0005737 cytoplasm KOG0325 Lipoyltransferase Cluster-9582.0 BP_3 3.00 0.31 758 646708716 KDR14903.1 1131 3.5e-121 CCR4-NOT transcription complex subunit 4 [Zootermopsis nevadensis] 884971743 XM_010889777.2 136 8.30047e-63 PREDICTED: Esox lucius CCR4-NOT transcription complex, subunit 4 (cnot4), mRNA K10643 CNOT4, NOT4, MOT2 CCR4-NOT transcription complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10643 Q8BT14 1076 3.4e-116 CCR4-NOT transcription complex subunit 4 OS=Mus musculus GN=Cnot4 PE=1 SV=2 PF14634//PF00097//PF00076//PF13639 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ring finger domain -- -- GO:0008270//GO:0003676//GO:0005515//GO:0046872 zinc ion binding//nucleic acid binding//protein binding//metal ion binding -- -- KOG2068 MOT2 transcription factor Cluster-9583.0 BP_3 6.00 1.16 542 857970642 CEP03007.1 315 1.0e-26 hypothetical protein PBRA_009225 [Plasmodiophora brassicae] 697090708 XM_009659931.1 515 0 Verticillium dahliae VdLs.17 60S ribosomal protein L43 mRNA K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 Q751L1 302 1.4e-26 60S ribosomal protein L43 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=RPL43 PE=3 SV=1 PF01780 Ribosomal L37ae protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0402 60S ribosomal protein L37 Cluster-9589.0 BP_3 5.00 0.50 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-9590.0 BP_3 4.00 3.21 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006525//GO:0006560//GO:0006814//GO:0006090//GO:0071436 arginine metabolic process//proline metabolic process//sodium ion transport//pyruvate metabolic process//sodium ion export GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-9593.0 BP_3 29.00 0.80 2038 728418110 AIY68357.1 1309 2.2e-141 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 Q5XG92 596 4.2e-60 Carboxylesterase 4A OS=Homo sapiens GN=CES4A PE=2 SV=2 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-9594.0 BP_3 4.00 0.49 684 815803051 XP_012222217.1 275 5.8e-22 PREDICTED: SAM and SH3 domain-containing protein 1 isoform X3 [Linepithema humile] -- -- -- -- -- -- -- -- -- P59808 221 4.3e-17 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF00018 SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-9596.0 BP_3 4.00 0.36 825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-96.0 BP_3 16.00 3.53 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9615.0 BP_3 5.00 0.87 570 340368518 XP_003382798.1 196 6.9e-13 PREDICTED: 60S ribosomal protein L38-like [Amphimedon queenslandica] 697081066 XM_009655736.1 565 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA K02923 RP-L38e, RPL38 large subunit ribosomal protein L38e http://www.genome.jp/dbget-bin/www_bget?ko:K02923 Q9C2B9 267 1.7e-22 60S ribosomal protein L38 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rpl-38 PE=3 SV=1 PF01781 Ribosomal L38e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3499 60S ribosomal protein L38 Cluster-9618.0 BP_3 3.00 0.33 729 501293558 BAN20619.1 600 1.3e-59 arginine/serine-rich-splicing factor [Riptortus pedestris] -- -- -- -- -- K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q94901 541 3.6e-54 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF08777//PF08675//PF00076//PF16367//PF00098//PF04847 RNA binding motif//RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Zinc knuckle//Calcipressin GO:0051252//GO:0019722//GO:0006402 regulation of RNA metabolic process//calcium-mediated signaling//mRNA catabolic process GO:0008270//GO:0003676//GO:0004535//GO:0046872//GO:0003723 zinc ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-9621.0 BP_3 1.00 0.33 438 780644019 XP_011688710.1 160 7.9e-09 PREDICTED: WD repeat-containing protein 87 isoform X1 [Wasmannia auropunctata]>gi|780644024|ref|XP_011688711.1| PREDICTED: WD repeat-containing protein 87 isoform X1 [Wasmannia auropunctata]>gi|780644029|ref|XP_011688712.1| PREDICTED: WD repeat-containing protein 87 isoform X1 [Wasmannia auropunctata]>gi|780644033|ref|XP_011688713.1| PREDICTED: WD repeat-containing protein 87 isoform X1 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9623.0 BP_3 5.82 0.78 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9627.0 BP_3 5.00 0.46 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03821//PF00901 Golgi 4-transmembrane spanning transporter//Orbivirus outer capsid protein VP5 -- -- GO:0005198 structural molecule activity GO:0019028//GO:0016021 viral capsid//integral component of membrane -- -- Cluster-9631.0 BP_3 3.00 0.33 733 -- -- -- -- -- 768311757 CP010985.1 631 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence -- -- -- -- -- -- -- -- PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-9644.0 BP_3 7.00 0.34 1293 328796228 AEB40303.1 408 4.1e-37 mitochondrial ATP synthase delta subunit precursor [Litopenaeus vannamei] -- -- -- -- -- K02134 ATPeF1D, ATP5D, ATP16 F-type H+-transporting ATPase subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K02134 P05630 244 1.8e-19 ATP synthase subunit delta, mitochondrial OS=Bos taurus GN=ATP5D PE=1 SV=2 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1758 Mitochondrial F1F0-ATP synthase, subunit delta/ATP16 Cluster-9645.0 BP_3 3.00 0.34 712 321460570 EFX71611.1 1099 1.7e-117 hypothetical protein DAPPUDRAFT_327006 [Daphnia pulex] 554844495 XM_005932546.1 169 3.51556e-81 PREDICTED: Haplochromis burtoni radixin-like (LOC102308311), transcript variant X2, mRNA K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q32LP2 1071 1.2e-115 Radixin OS=Bos taurus GN=RDX PE=2 SV=1 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-9648.0 BP_3 4.00 1.44 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9652.0 BP_3 2.00 0.32 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9655.0 BP_3 3.95 0.31 896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9666.0 BP_3 2.00 0.37 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00861//PF04055 Ribosomal L18p/L5e family//Radical SAM superfamily GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003824//GO:0051536 structural constituent of ribosome//catalytic activity//iron-sulfur cluster binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-967.0 BP_3 1.00 0.37 421 270004161 EFA00609.1 208 2.1e-14 hypothetical protein TcasGA2_TC003484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9671.0 BP_3 5.00 0.85 575 170037145 XP_001846420.1 605 2.6e-60 NADH dehydrogenase [Culex quinquefasciatus]>gi|167880174|gb|EDS43557.1| NADH dehydrogenase [Culex quinquefasciatus] -- -- -- -- -- K03966 NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03966 Q1HPL8 525 2.0e-52 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4009 NADH-ubiquinone oxidoreductase, subunit NDUFB10/PDSW Cluster-9675.0 BP_3 3.00 0.78 478 602680373 XP_007452994.1 321 1.9e-27 PREDICTED: putative nitroreductase HBN1-like [Lipotes vexillifer]>gi|255303376|gb|EET82580.1| nitroreductase family protein [Acinetobacter radioresistens SK82]>gi|400204643|gb|EJO35627.1| nitroreductase family protein [Acinetobacter radioresistens WC-A-157]>gi|403187416|dbj|GAB75633.1| hypothetical protein ACRAD_32_00060 [Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788]>gi|480049105|gb|ENV88248.1| hypothetical protein F939_01873 [Acinetobacter radioresistens DSM 6976 = NBRC 102413 = CIP 103788]>gi|587839441|gb|EXB30102.1| nitroreductase family protein [Acinetobacter baumannii 1461402]>gi|587878935|gb|EXB67920.1| nitroreductase family protein [Acinetobacter baumannii 230853]>gi|588137602|gb|EXE13365.1| nitroreductase family protein [Acinetobacter baumannii 983759]>gi|588677852|gb|EXF56087.1| nitroreductase family protein [Acinetobacter baumannii 1294596] 768311754 CP010982.1 466 0 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- Q96VH4 181 1.3e-12 Putative nitroreductase HBN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HBN1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9677.0 BP_3 7.00 0.64 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9678.0 BP_3 4.00 0.71 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9683.0 BP_3 8.65 1.03 695 -- -- -- -- -- 697068024 XM_009650902.1 669 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- P09940 146 2.2e-08 ATPase inhibitor, mitochondrial OS=Cyberlindnera jadinii PE=1 SV=1 PF07086//PF04568 Jagunal, ER re-organisation during oogenesis//Mitochondrial ATPase inhibitor, IATP GO:0007029//GO:0032780 endoplasmic reticulum organization//negative regulation of ATPase activity GO:0042030 ATPase inhibitor activity GO:0005739//GO:0005789 mitochondrion//endoplasmic reticulum membrane -- -- Cluster-9693.0 BP_3 2.00 0.34 578 815825447 XP_012234099.1 244 1.9e-18 PREDICTED: uncharacterized protein LOC105678945 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01667//PF05121//PF00001 Ribosomal protein S27//Gas vesicle protein K//7 transmembrane receptor (rhodopsin family) GO:0006412//GO:0031412//GO:0007186//GO:0042254 translation//gas vesicle organization//G-protein coupled receptor signaling pathway//ribosome biogenesis GO:0004930//GO:0003735 G-protein coupled receptor activity//structural constituent of ribosome GO:0016021//GO:0005622//GO:0005840 integral component of membrane//intracellular//ribosome -- -- Cluster-97.0 BP_3 22.00 1.05 1300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9706.0 BP_3 27.00 1.00 1598 91090338 XP_967017.1 1028 6.5e-109 PREDICTED: amine sulfotransferase [Tribolium castaneum]>gi|270013419|gb|EFA09867.1| hypothetical protein TcasGA2_TC012015 [Tribolium castaneum] -- -- -- -- -- K01014 SULT1A aryl sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01014 O46640 363 3.5e-33 Amine sulfotransferase OS=Oryctolagus cuniculus GN=SULT3A1 PE=1 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-9711.0 BP_3 5.00 0.45 823 -- -- -- -- -- 338224430 HM217860.1 39 7.55864e-09 Scylla paramamosain isolate 2 polyprotein-like mRNA, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9714.1 BP_3 1.00 0.39 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9720.0 BP_3 8.00 0.45 1150 755980605 XP_011309301.1 247 1.7e-18 PREDICTED: glycine-rich protein DOT1-like isoform X2 [Fopius arisanus] -- -- -- -- -- K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q8C7Q4 191 2.2e-13 RNA-binding protein 4 OS=Mus musculus GN=Rbm4 PE=1 SV=1 PF16367//PF00076//PF08675 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-9727.0 BP_3 6.00 0.62 756 238683649 ACR54103.1 396 5.9e-36 ATP synthase subunit g [Palaemon varians] -- -- -- -- -- K02140 ATPeFG, ATP5L, ATP20 F-type H+-transporting ATPase subunit g http://www.genome.jp/dbget-bin/www_bget?ko:K02140 Q5RFH0 259 1.9e-21 ATP synthase subunit g, mitochondrial OS=Pongo abelii GN=ATP5L PE=3 SV=1 PF04718 Mitochondrial ATP synthase g subunit GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG4103 Mitochondrial F1F0-ATP synthase, subunit g/ATP20 Cluster-9730.0 BP_3 11.00 0.44 1504 568904578 XP_006544541.1 1161 2.3e-124 PREDICTED: aspartate aminotransferase, cytoplasmic-like, partial [Mus musculus] 768311757 CP010985.1 1301 0 Verticillium dahliae VdLs.17 chromosome 6, complete sequence K14454 GOT1 aspartate aminotransferase, cytoplasmic http://www.genome.jp/dbget-bin/www_bget?ko:K14454 P23542 1041 7.8e-112 Aspartate aminotransferase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AAT2 PE=1 SV=3 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-9733.0 BP_3 21.00 1.03 1277 -- -- -- -- -- 768311759 CP010987.1 906 0 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9736.0 BP_3 11.00 1.34 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9742.0 BP_3 3.00 0.74 488 676458395 XP_009054961.1 163 4.0e-09 hypothetical protein LOTGIDRAFT_71188, partial [Lottia gigantea]>gi|556105644|gb|ESO94296.1| hypothetical protein LOTGIDRAFT_71188, partial [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9746.0 BP_3 1.00 1.01 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9748.0 BP_3 1.00 2.07 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9768.0 BP_3 13.00 31.14 289 469664513 AGH70211.1 249 2.5e-19 40S ribosomal protein S28 [Placozoa sp. H4] 256709225 GQ422265.1 78 5.12581e-31 Diplogastrellus gracilis small subunit ribosomal protein 28 (rps-28) mRNA, partial cds K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 P62857 229 2.2e-18 40S ribosomal protein S28 OS=Homo sapiens GN=RPS28 PE=1 SV=1 PF01200 Ribosomal protein S28e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3502 40S ribosomal protein S28 Cluster-9769.0 BP_3 2.00 0.35 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9774.0 BP_3 3.00 0.44 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9777.0 BP_3 12.21 0.49 1505 642938789 XP_008199887.1 956 1.4e-100 PREDICTED: uncharacterized protein LOC657763 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9781.0 BP_3 7.00 0.31 1385 642910535 XP_008200253.1 308 1.7e-25 PREDICTED: protein bunched, class 2/F/G isoform-like isoform X1 [Tribolium castaneum]>gi|642910537|ref|XP_008200254.1| PREDICTED: protein bunched, class 2/F/G isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24523 156 3.0e-09 Protein bunched, class 2/F/G isoform OS=Drosophila melanogaster GN=bun PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-9786.1 BP_3 3.00 0.53 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9788.0 BP_3 6.00 0.59 783 694530988 XP_009494036.1 217 3.5e-15 cytochrome c oxidase subunit IV [Fonticula alba]>gi|627949049|gb|KCV70913.1| cytochrome c oxidase subunit IV [Fonticula alba] 697081168 XM_009655771.1 771 0 Verticillium dahliae VdLs.17 cytochrome c oxidase polypeptide V mRNA -- -- -- -- P06810 553 1.6e-55 Cytochrome c oxidase polypeptide 5, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cya-4 PE=3 SV=2 PF02936 Cytochrome c oxidase subunit IV GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-9792.0 BP_3 7.00 0.34 1293 642927085 XP_008195131.1 763 2.8e-78 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULI1 234 2.5e-18 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF03193//PF01637//PF09025 Protein of unknown function, DUF258//Archaeal ATPase//YopR, type III needle-polymerisation regulator GO:0009405//GO:0030254 pathogenesis//protein secretion by the type III secretion system GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding GO:0030257 type III protein secretion system complex -- -- Cluster-980.0 BP_3 2.00 0.34 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9800.0 BP_3 2.00 0.32 590 646715440 KDR19052.1 382 1.9e-34 Mitogen-activated protein-binding protein-interacting protein [Zootermopsis nevadensis] 556991584 XM_006000274.1 59 4.05978e-20 PREDICTED: Latimeria chalumnae late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 (LAMTOR2), transcript variant X3, mRNA -- -- -- -- Q6DEG4 363 1.3e-33 Ragulator complex protein LAMTOR2 OS=Danio rerio GN=lamtor2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9810.0 BP_3 9.00 0.69 923 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9815.0 BP_3 3.00 0.53 566 758375888 AJO70196.1 884 1.1e-92 sodium-calcium exchanger 1 [Cherax cainii] -- -- -- -- -- K05849 SLC8A, NCX solute carrier family 8 (sodium/calcium exchanger) http://www.genome.jp/dbget-bin/www_bget?ko:K05849 P70549 355 1.0e-32 Sodium/calcium exchanger 3 OS=Rattus norvegicus GN=Slc8a3 PE=2 SV=1 PF01699//PF03160 Sodium/calcium exchanger protein//Calx-beta domain GO:0055085//GO:0007154 transmembrane transport//cell communication -- -- GO:0016021 integral component of membrane KOG1306 Ca2+/Na+ exchanger NCX1 and related proteins Cluster-983.0 BP_3 1.00 0.47 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9833.0 BP_3 2.00 0.73 423 820124648 KKX03302.1 274 4.6e-22 cytochrome c oxidase subunit 6B1-like [Scleropages formosus] 697083930 XM_009656729.1 309 3.0227e-159 Verticillium dahliae VdLs.17 cytochrome c oxidase polypeptide VIb mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 O94581 301 1.4e-26 Cytochrome c oxidase subunit 6B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cox12 PE=3 SV=2 PF02297 Cytochrome oxidase c subunit VIb GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005739//GO:0045277 mitochondrion//respiratory chain complex IV KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-9837.0 BP_3 33.00 0.84 2181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9838.0 BP_3 2.00 3.37 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9847.0 BP_3 7.00 0.43 1070 -- -- -- -- -- 686705226 XM_009233297.1 61 5.84782e-21 PREDICTED: Pongo abelii zinc finger, DHHC-type containing 18 (ZDHHC18), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9855.1 BP_3 2.00 0.32 594 242008167 XP_002424883.1 420 7.7e-39 vacuolar amino acid transporter, putative [Pediculus humanus corporis]>gi|212508448|gb|EEB12145.1| vacuolar amino acid transporter, putative [Pediculus humanus corporis] -- -- -- -- -- K14996 SLC38A10 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14996 Q5I012 300 2.6e-26 Putative sodium-coupled neutral amino acid transporter 10 OS=Mus musculus GN=Slc38a10 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1305 Amino acid transporter protein Cluster-9861.0 BP_3 8.00 0.55 995 645020504 XP_008207188.1 840 2.5e-87 PREDICTED: protein bric-a-brac 2 isoform X3 [Nasonia vitripennis] 768448620 XM_011568049.1 64 1.16591e-22 PREDICTED: Plutella xylostella uncharacterized LOC105396066 (LOC105396066), mRNA -- -- -- -- -- -- -- -- PF01527//PF04218//PF05225//PF02796//PF02954 Transposase//CENP-B N-terminal DNA-binding domain//helix-turn-helix, Psq domain//Helix-turn-helix domain of resolvase//Bacterial regulatory protein, Fis family GO:0006313//GO:0006310 transposition, DNA-mediated//DNA recombination GO:0000150//GO:0004803//GO:0043565//GO:0003677 recombinase activity//transposase activity//sequence-specific DNA binding//DNA binding -- -- -- -- Cluster-9862.0 BP_3 1.00 0.46 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane -- -- Cluster-9876.0 BP_3 4.00 0.33 869 5231228 NP_003721.2 1225 5.1e-132 ribonuclease T2 precursor [Homo sapiens]>gi|20139363|sp|O00584.2|RNT2_HUMAN RecName: Full=Ribonuclease T2; AltName: Full=Ribonuclease 6; Flags: Precursor>gi|5091495|gb|AAC51363.2| ribonuclease 6 precursor [Homo sapiens]>gi|12804499|gb|AAH01660.1| Ribonuclease T2 [Homo sapiens]>gi|12804759|gb|AAH01819.1| Ribonuclease T2 [Homo sapiens]>gi|20145501|emb|CAD12030.1| extra-cellular ribonuclease [Homo sapiens]>gi|24981026|gb|AAH39713.1| Ribonuclease T2 [Homo sapiens]>gi|30354311|gb|AAH51912.1| Ribonuclease T2 [Homo sapiens]>gi|119567897|gb|EAW47512.1| ribonuclease T2, isoform CRA_b [Homo sapiens]>gi|119567898|gb|EAW47513.1| ribonuclease T2, isoform CRA_b [Homo sapiens]>gi|119567899|gb|EAW47514.1| ribonuclease T2, isoform CRA_b [Homo sapiens]>gi|189067916|dbj|BAG37854.1| unnamed protein product [Homo sapiens]>gi|649104699|gb|AIC50165.1| RNASET2, partial [synthetic construct] 164695657 AK315467.1 869 0 Homo sapiens cDNA, FLJ96527, Homo sapiens ribonuclease 6 precursor (RNASE6PL), mRNA K01166 E3.1.27.1 ribonuclease T2 http://www.genome.jp/dbget-bin/www_bget?ko:K01166 O00584 1225 2.1e-133 Ribonuclease T2 OS=Homo sapiens GN=RNASET2 PE=1 SV=2 PF00445 Ribonuclease T2 family GO:0006401 RNA catabolic process GO:0033897//GO:0003723 ribonuclease T2 activity//RNA binding GO:0005788//GO:0043202//GO:0005615 endoplasmic reticulum lumen//lysosomal lumen//extracellular space KOG1642 Ribonuclease, T2 family Cluster-9877.0 BP_3 4.98 0.56 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9881.0 BP_3 4.00 0.35 846 -- -- -- -- -- 697083575 XM_009656606.1 837 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9882.0 BP_3 4.00 0.53 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9884.0 BP_3 13.00 0.75 1132 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9886.0 BP_3 1.00 0.74 352 -- -- -- -- -- 697089572 XM_009659400.1 349 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- PF11593//PF00643 Mediator complex subunit 3 fungal//B-box zinc finger GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0008270//GO:0001104 zinc ion binding//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005622 mediator complex//intracellular -- -- Cluster-9888.0 BP_3 1.67 0.51 448 270015247 EFA11695.1 253 1.3e-19 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9894.0 BP_3 2.00 0.34 579 478259039 ENN78985.1 641 1.8e-64 hypothetical protein YQE_04569, partial [Dendroctonus ponderosae]>gi|546684161|gb|ERL93866.1| hypothetical protein D910_11152 [Dendroctonus ponderosae] 657759800 XM_008316875.1 135 2.24728e-62 PREDICTED: Cynoglossus semilaevis putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (LOC103383656), mRNA K12820 DHX15, PRP43 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12820 O43143 603 1.8e-61 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens GN=DHX15 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-9896.0 BP_3 1.00 0.35 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-99.0 BP_3 2.00 0.53 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9900.0 BP_3 5.00 0.31 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9907.0 BP_3 1.00 0.54 379 189233695 XP_001812208.1 390 1.5e-35 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] 27635081 BX061800.1 65 1.16751e-23 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC42DB07 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 Q08170 350 2.6e-32 Serine/arginine-rich splicing factor 4 OS=Homo sapiens GN=SRSF4 PE=1 SV=2 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-9917.0 BP_3 1.00 1.62 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9922.0 BP_3 6.00 0.58 787 -- -- -- -- -- 532874323 KF452350.1 91 8.94378e-38 Scylla paramamosain microsatellite Scpa106 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9940.0 BP_3 4.00 0.63 598 -- -- -- -- -- 327134014 AB621370.1 98 8.60452e-42 Pyrus pyrifolia gene for 5S ribosomal RNA, partial sequence, cultivar: Hosui -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9940.3 BP_3 2.00 0.35 568 -- -- -- -- -- 328909928 HQ263322.1 223 2.65382e-111 Prunus persica clone NBS73 genomic sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9940.5 BP_3 1.00 1.18 322 -- -- -- -- -- 20162 Z11475.1 237 2.37032e-119 O.sativa 5S DNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9946.0 BP_3 2.00 0.35 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9948.0 BP_3 2.00 0.44 511 -- -- -- -- -- 697067538 XM_009650659.1 511 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-995.0 BP_3 4.00 0.38 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9951.0 BP_3 1.00 0.35 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9956.0 BP_3 3.00 0.33 731 262401101 ACY66453.1 911 1.1e-95 prohibitin [Scylla paramamosain] 345452838 HQ260917.1 725 0 Scylla paramamosain prohibitin mRNA, complete cds K17080 PHB1 prohibitin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17080 P84173 741 2.3e-77 Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3083 Prohibitin Cluster-9959.0 BP_3 2.00 0.31 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9962.0 BP_3 9.00 1.08 693 221220918 ACM09120.1 256 9.3e-20 40S ribosomal protein S28 [Salmo salar] 697076618 XM_009654200.1 489 0 Verticillium dahliae VdLs.17 40S ribosomal protein S28 mRNA K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 Q7S6W5 263 5.9e-22 40S ribosomal protein S28 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-28 PE=3 SV=1 PF01200 Ribosomal protein S28e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-9970.0 BP_3 3.00 0.34 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9976.0 BP_3 2.57 0.45 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9984.0 BP_3 3.00 0.63 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9986.0 BP_3 2.00 0.43 514 752876355 XP_011255570.1 235 1.9e-17 PREDICTED: nephrin-like isoform X3 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- --